bioRxiv directory

Li, H.; Melnyk, J. E.; Fu, B. X. H.; Shrestha, R.; Zhang, M.; Sjostrom, M.; Feng, S.; Anderson, J.; Han, W.; Chesner, L. N.; Shin, H. J.; Farsh, T.; Suarez, H. J.; Nath, S.; Chou, J.; Das, R.; Egusa, E. A.; Calvert, M.; Kishishita, A.; Barpanda, A.; Zhu, J.; Maheshwari, A.; Chen, W. S.; Alshalalfa, M.; Winters, A.; Hua, J. T.; Liu, T.; Davicioni, E.; Wiita, A. P.; Stohr, B. A.; Siddiqui, J.; Huang, B.; Small, E. J.; Shokat, K. M.; Nelson, P.; Quigley, D. A.; Wasmuth, E. V.; Gilbert, L. A.; Feng, F. Y.

10.1101/2025.05.29.656244 — cancer biology — Posted on 2025-05-31

3 Loss of tumor suppressor p53 upregulates stem cell factor SOX9 via Notch signaling

Sanawar, R.; Guo, W.

10.1101/2025.05.27.656408 — cancer biology — Posted on 2025-05-31

4 cytoFlagR: A comprehensive framework to objectively assess high-parameter cytometry data for batch effects

Eswar, S.; Koenig, Z. T.; Tursi, A. R.; Cobena-Reyes, J.; Tilburgs, T.; Andorf, S.

10.1101/2025.05.27.656370 — bioinformatics — Posted on 2025-05-31

5 Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Xiong, H.-D.; Ji-An, L.; Mattar, M. G.; Wilson, R. C.

10.1101/2025.03.21.644663 — animal behavior and cognition — Posted on 2025-05-31

6 Low-dimensional genotype-fitness mapping across divergent environments suggests a limiting functions model of fitness

Ghosh, O. M.; Kinsler, G.; Good, B. H.; Petrov, D.

10.1101/2025.04.05.647371 — evolutionary biology — Posted on 2025-05-31

7 Context-Seq: CRISPR-Cas9 Targeted Nanopore Sequencing for Transmission Dynamics of Antimicrobial Resistance

Fuhrmeister, E. R.; Kim, S.; Mairal, S. A.; McCormack, C.; Chieng, B.; Swarthout, J. M.; Paulos, A. H.; Njenga, S. M.; Pickering, A. J.

10.1101/2024.09.12.612745 — microbiology — Posted on 2025-05-31

8 Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

Guan, C.; Ryu, S.; Dong, M.; Youm, Y.-H.; Mohanty, S.; Maeda, R.; Orliaguet, L.; Kim, H.-H.; Dlugos, T.; Smith, S. R.; Ravussin, E.; Onyuru, J.; Wang, A.; Shaw, A. C.; Hoffman, H. M.; Kluger, Y.; Sugiura, Y.; Dixit, V. D.

10.1101/2025.05.27.656381 — immunology — Posted on 2025-05-31

9 Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications

Liang, P.; Wan, Y.-C. S.; Shan, K. Z.; Chou, R.; Zhang, Y.; Delahunty, M.; Khandelwal, S.; Francis, S.; Arepally, G. M.; Telen, M. J.; Yang, H.

10.1101/2025.05.27.656389 — physiology — Posted on 2025-05-31

10 Oxidative stress and vacuolar variants influence paraquat response in Saccharomyces cerevisiae of different genetic variants

Rubilar, J. C.; Szenfeld, B.; Cubillos, F. A.; Klein, A. D.

10.1101/2025.05.27.656361 — pharmacology and toxicology — Posted on 2025-05-31

11 Midkine inhibits dormancy of disseminated melanoma cells

Tirado, C. A. R.; Riaz, T. A.; Rodrigues, A. A.; Kale, N.; Satheeshkumar, S. J.; Perez-Gallegos, A.; Olmeda, D.; Soengas, M. S.; Sosa, M. S.

10.1101/2025.05.27.656365 — cancer biology — Posted on 2025-05-31

12 Differences in GenBank and RefSeq annotations may affect genomics data interpretation for Pseudomonas putida KT2440

de Siqueira, G. M. V.; Eng, T.; Mukhopadhyay, A.; Guazzaroni, M.-E.

10.1101/2025.05.27.656432 — bioinformatics — Posted on 2025-05-31

13 Analysis of isobaric quantitative proteomic data using TMT-Integrator and FragPipe computational platform

Chang, H.-Y.; Deng, Y.; Li, R.; Avtonomov, D.; Wen, B.; Haynes, S. E.; Leprevost, F. d. V.; Zhang, B.; Yu, F.; Nesvizhskii, A. I.

10.1101/2025.05.27.656447 — bioinformatics — Posted on 2025-05-31

14 Full-length isoform constructor (FLIC) - a tool for isoform discovery based on long reads

Kasianova, A. M.; Klepikova, A. V.; Gusev, O. A.; Gazizova, G. R.; Logacheva, M. D.; Penin, A. A.

10.1101/2025.05.27.656444 — bioinformatics — Posted on 2025-05-31

15 Endogenous Estrogen-Mimetic Compounds in Cell Culture Media Influence Human Mesenchymal Stromal Cell (hMSC) Processes and Differentiation in a Sex-Biased Manner

Bradford, J. C.; Robinson, J. L.

10.1101/2025.05.27.656455 — bioengineering — Posted on 2025-05-31

16 Detecting branching rate heterogeneity with tree balance statistics in lineage tracing trees

Gao, Y.; Feder, A. F.

10.1101/2024.06.27.601073 — evolutionary biology — Posted on 2025-05-31

17 An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut

Spiga, L.; Fansler, R. T.; Grote, A.; Langford-Butler, M.; Miller, A. K.; Neal, M.; Hale, O. F.; Wu, Y.; Singla, D.; Calcutt, M. W.; Rose, A. E.; Bresson, M. M.; Schrimpe-Rutledge, A. C.; Berdy, B.; Codreanu, S. G.; Washington, M. K.; Bratton, B. P.; Sherrod, S. D.; McLean, J. A.; Zengler, K.; Sears, C. L.; Behringer, M. G.; Gnirke, A.; Livny, J.; Olivares-Villagomez, D.; Earl, A. M.; Zhu, W.

10.1101/2025.05.31.657111 — microbiology — Posted on 2025-05-31

18 Platelet DKK1 promotes tolerogenic dendritic cells and non-healing responses in cutaneous leishmaniasis

Ihedioha, O.; Sivakoses, A.; Marcarian, H. Q.; Sajeev, M.; McMahon-Pratt, D.; Bothwell, A. L. M.

10.1101/2025.05.27.656395 — immunology — Posted on 2025-05-31

19 Influenza A virus infection during pregnancy increases transfer of maternal bloodborne molecules to fetal tissues

Gonzalez-Ricon, R. J.; Otero, A. M.; Chalen, I.; Savas, J.; Antonson, A. M.

10.1101/2025.05.27.656420 — neuroscience — Posted on 2025-05-31

20 DNA framework array enables ultra-high throughput DNA synthesis

Li, C.; Saimaiti, Y.; Li, M.; Wang, S.; Yin, F.; Fang, Z.; Jia, S.; Wang, F.; Ye, D.; Wang, L.; Zuo, X.; Fan, C.

10.1101/2025.05.30.657018 — synthetic biology — Posted on 2025-05-31

21 Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

Tiede, D. R.; Plotkin, D. L.; McIntosh, M. C.; Michel, J. M.; Huggins, K. W.; Beck, D. T.; Goodlett, M. D.; Carr, J. C.; Schoenfeld, B. J.; Mobley, C. B.; Young, K. C.; Swinton, P. A.; Fruge, A. D.; Roberts, M. D.

10.1101/2025.05.27.656407 — physiology — Posted on 2025-05-31

22 Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction

Lee, H. N. R.; Lin, J.; Smith, C. J.; Ware, L. B.; Harrison, F. E.; Bastarache, J. A.; Baer, B.

10.1101/2025.05.27.656343 — physiology — Posted on 2025-05-31

23 Longitudinal multi-omic profiling uncovers immune escape and predictors of response in multiple myeloma

Ohlstrom, D.; Pilcher, W. C.; Michaud, M. E.; Acharya, C. R.; Satpathy, S.; Gonzalez-Kozlova, E.; Jayasinghe, R. G.; Ferguson, K. E.; Mumme, H.; Nanda, S.; Song, Y.; Mantrala, S. K.; Karagkouni, D.; Schulman, J.; Pabustan, N.; Vieira Dos Santos, J.; Sherbenou, D.; Keats, J.; Gout, A.; Foltz, S.; Lagana, A.; Kourelis, T.; Vij, R.; Dhodapkar, M. V.; Avigan, D.; Cho, H. J.; Baughn, L. B.; Nooka, A.; Lonial, S.; Kumar, S.; Samur, M.; Vlachos, I.; Ding, L.; Gnjatic, S.; Mulligan, G.; Bhasin, M.

10.1101/2025.05.27.656392 — cancer biology — Posted on 2025-05-31

24 Early Radiation Therapy Response Assessment using Multi-scale Photoacoustic Imaging

Lefebvre, T. L.; Oraiopoulou, M.-E.; Bunce, E. V.; Else, T. R.; Wright, L. C.; Golinska, M. A.; Hacker, L.; Brodie, C.; Kupczak, S.; Cheng, Y.; Young, L.; Sweeney, P. W.; Bohndiek, S. E.

10.1101/2025.05.27.656322 — cancer biology — Posted on 2025-05-31

25 Improved quantitative accuracy in data-independent acquisition proteomics via retention time boundary imputation

Harris, L. J.; Riffle, M.; Noble, W. S.; MacCoss, M. J.

10.1101/2025.05.27.656394 — bioinformatics — Posted on 2025-05-31

26 Confounding factors in assessing the enriched expression of somatic mutant allele in bulk tumor samples

Hagiwara, K.; Thrasher, A.; Terekhanova, N. V.; Zhang, J.

10.1101/2025.05.27.656366 — bioinformatics — Posted on 2025-05-31

27 Prediction of metabolic dynamics through deep learning and high-throughput multiomics data

Marti, J. M.; Kinnunen, P. C.; Held, M.; Alikhani, A.; Conley, A.; Chen, Y.; Radivojevic, T.; Gin, J. W.; Zournas, A.; Lennen, R. M.; Hefzi, H.; Baniodeh, M.; Harrington, P.; Forrer, M.; Melis, D.; Dietrich, J.; Holtz, W.; Ohler, N.; Petzold, C. J.; Martin, H. G.

10.1101/2025.05.27.656438 — bioengineering — Posted on 2025-05-31

28 A fluorescent reporter and single-turnover kinetics reveal new insight into BAM complex function

Bergman, W. N.; Sousa, M. C.

10.1101/2025.05.30.657120 — biochemistry — Posted on 2025-05-31

29 FUNCTIONAL ANALYSIS OF BIPARTITE NRF2 ACTIVATORS THAT OVERCOME FEEDBACK REGULATION FOR AGE-RELATED CHRONIC DISEASES

Hushpulian, D. M.; Ammal Kaidery, N.; Soni, P.; Poloznikov, A. A.; Zakhariants, A. A.; Razumovskaya, A. V.; Silkina, M. O.; Tishkov, V.; Kazakov, E. H.; Brown, A. M.; Gaisina, I. N.; Ahn, Y.-H.; Kazakov, S. V.; Krucher, N.; Sharma, S. M.; Paul, B. D.; Gazaryan, I. G.; Nikulin, S. V.; Thomas, B.

10.1101/2025.05.30.656434 — biochemistry — Posted on 2025-05-31

30 Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists

Hsu, C.; Shulman, N.; Stewart, H.; Petzoldt, J.; Pashkova, A.; Plubell, D.; Denisov, E.; Hagedorn, B.; Damoc, E.; MacLean, B. X.; Remes, P. M.; Canterbury, J. D.; Makarov, A.; Hock, C.; Zabrouskov, V.; Wu, C. C.; MacCoss, M. J.

10.1101/2025.05.30.657132 — biochemistry — Posted on 2025-05-31

31 Off-Target Structural Insights: ArnA and AcrB in Bacterial Membrane Protein Cryo-EM Analysis

Caliseki, M.; Borucu, U.; Yadav, S.; Schaffitzel, C.; Kabasakal, B. V.

10.1101/2025.05.31.656883 — biochemistry — Posted on 2025-05-31

32 Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression

Rosonovski, S. S.; Guneri, D.; King, J. J.; Morris, C. J.; Waller, Z. A. E.

10.1101/2025.05.30.656635 — molecular biology — Posted on 2025-05-31

33 PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling

Cen, Y.; R. Alves, S.; Song, D.; Preall, J.; Van Aelst, L.; Tonks, N. K.

10.1101/2025.05.30.657101 — molecular biology — Posted on 2025-05-31

34 HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution

Trupej, A.; Bergant, V.; Novljan, J.; Dodel, M.; Klobucar, T.; Adamek, M.; Lee, F. C. Y.; Yap, K.; Makeyev, E.; Kokot, B.; Cehovin Zajc, L.; Pichlmair, A.; Urbancic, I.; Mardakheh, F. K.; Modic, M.

10.1101/2025.05.30.656369 — molecular biology — Posted on 2025-05-31

35 A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring

Bellamy, C.; Tovell, H.; Schwaighofer, S.; Baffi, T.; Arslan, J.; Letourneur, Q.; Dingli, F.; Loew, D.; Kornev, A.; Lerond, J.; Kao, T.; Liva, S.; Izac, B.; Andrieu, M.; Adle-Biassette, H.; Barnier, J.-V.; Stefan, E.; Sanson, M.; Newton, A.; Bielle, F.

10.1101/2025.05.30.657104 — molecular biology — Posted on 2025-05-31

36 Distinct immunity protein families mediate compartment-specificneutralisation of a bacterial toxin

Alcock, F.; Yang, Y.; Deme, J.; Casabona, G.; Mendonca, C.; Ulhuq, F.; Lea, S. M.; Palmer, T.

10.1101/2025.05.31.657152 — microbiology — Posted on 2025-05-31

37 Impacts of wastewater treatment and the exposome on antibiotic resistance gene dynamics: Insights from Guadeloupe, a French Caribbean Island

Alexa, M.; Kovacevic, A.; Pimenta, M.; Batantou Mabandza, D.; Ahmed, I.; Breurec, S.; DAGOT, C.; Huynh, B.-T.; Opatowski, L.

10.1101/2025.05.31.657145 — microbiology — Posted on 2025-05-31

38 MARISMa: a routine MALDI-TOF MS database from 2018 to 2024

Schmidt-Santiago, L.; Lopez-Mareca, I.; Blazquez-Sanchez, M.; Moreno-Lopez, J. M.; Sevilla-Salcedo, C.; Gomez-Verdejo, V.; Rodriguez-Sanchez, B.; Rodriguez-Temporal, D.; Guerrero-Lopez, A.

10.1101/2025.05.31.657186 — microbiology — Posted on 2025-05-31

39 Ecological divergence of sympatric Saccharomyces species across wild and fermentative environments in the neotropics

Lopez-Gallegos, C.; Aguirre-Dugua, X.; Avelar-Rivas, J. A.; Kirchmayr, M. R.; Morales, L.; DeLuna, A.; Mancera, E.

10.1101/2025.05.31.656962 — microbiology — Posted on 2025-05-31

40 A conceptual framework for revealing minor bacterial signals inmicrobiome data through guided data transformation

MARTIN, D.; Houedry, P.; Derbre, F.; Monbet, V.

10.1101/2025.05.31.656121 — microbiology — Posted on 2025-05-31

41 Unified Genomic and Chemical Representations Enable Bidirectional Bio-synthetic Gene Cluster and Natural Product Retrieval

Liu, G.; Li, Y.; Ong, G.; Wong, F. T.; Tay, D. W. P.; Lim, Y. H.; Foo, C. S.; Koh, L. C. W.

10.1101/2025.05.31.656985 — synthetic biology — Posted on 2025-05-31

42 DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells

Baranda Pellejero, L.; Vonk-de Roy, M.; Baykal, D.; Lehmann, L.; Walther, A.

10.1101/2025.05.31.656672 — synthetic biology — Posted on 2025-05-31

43 Carbon-Efficient Conversion through Hydrogen and Formate-Driven Metabolism in Escherichia coli

Bertrand, R. L.; Panich, J.; Cowan, A. E.; Roberts, J. B.; Artier, J.; Toppari, E.; Baidoo, E. E.; Chen, Y.; Petzold, C. J.; Hudson, G. A.; Shih, P. M.; Singer, S. W.; Keasling, J. D.

10.1101/2025.05.30.657096 — synthetic biology — Posted on 2025-05-31

44 Programmed inhibition of an innate immune receptor via de novo designed transmembrane proteins

Maillie, C. A.; Zhang, M.; Goiset, N.; Goldenfeld, G.; Ward, A.; mravic, m.

10.1101/2025.05.31.657109 — biochemistry — Posted on 2025-05-31

45 Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease

Stratton, M. P.; Centa, J. L.; Swier, V. J.; Pfeifer, W. L.; Booth, C. D.; Albert, K.; Hunyara, J. L.; Rechtzigel, M. J.; Duelli, F. J.; Leppert, H. G.; Rigo, F.; Smit, T.; Jafar-Nejad, P.; Weimer, J. M.; Drack, A. V.; Hastings, M. L.

10.1101/2025.05.30.656864 — molecular biology — Posted on 2025-05-31

46 Low current and future spotted lanternfly suitability in New York wine-growing regions tempers vineyard risk

Eller, J. A.; Gold, K. M.; Emery, S. E.

10.1101/2025.05.28.656630 — ecology — Posted on 2025-05-31

47 Dissecting Oxidative Stress and Organismic Response to various Temperature Regimes in the midge C. riparius

Bulut, B.; Geiss, M.; Bernard, M.; Doria, H. B.; Feldmeyer, B.; Pfenninger, M.

10.1101/2025.05.28.656541 — ecology — Posted on 2025-05-31

48 HpBoRB, a helminth-derived CCP domain protein which binds RELMβ

Shek, V.; Jamwal, A. J.; Smyth, D. J.; Frangova, T.; Savage, A. R.; Kelly, S.; Wright, G. J.; Toth, R.; Maizels, R. M.; Higgins, M. K.; Ivens, A. C.; Smits, H. H.; McSorley, H. J.

10.1101/2025.05.27.656348 — immunology — Posted on 2025-05-31

49 Prenatal alcohol exposure promotes nerve injury-induced pathological pain following morphine treatment via NLRP3-mediated peripheral and central proinflammatory immune actions.

Pasmay, A. A.; Pritha, A. N.; Carter, J. R.; Jones, A.; Fernandez-Oropeza, A. K.; Sun, M. S.; Jimenez, D. C.; Murphy, M.; Valenzuela, C. F.; Noor, S.

10.1101/2025.05.30.655639 — neuroscience — Posted on 2025-05-31

50 When good guides go bad: empirical evaluation of all unique Cas9 targets in E. coli reveal widespread functionality and rules for gRNA biological design

Phillips, E. K.; Harrison, R.; Charles, S.; Klingeman, D. M.; Wiser, T. D.; Eckert, C. A.; Alexander, W. G.

10.1101/2025.05.23.651106 — synthetic biology — Posted on 2025-05-31

51 PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer

Young, A. A.; Juhler, I. G.; Pierce, J. R.; Bohlin, H. E.; Harper, H. A.; Onishile, D. S.; Chua, R. N.; Liu, M. E.; Gardner, E. N.; Elzey, B. D.; Cottrell, K. A.

10.1101/2025.05.27.656288 — cancer biology — Posted on 2025-05-31

52 Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

Cenzano, I.; Cocera, M.; Larrayoz, M.; Campos-Dopazo, L.; Sanz, S.; Bantan, A.; Vilas, A.; San-Martin, P.; Aguirre-Ruiz, P.; Alignani, D.; Lopez, A.; Sancho Gonzalez, I.; Ruiz, J.; Ripalda-Cemborain, P.; Abengozar-Muela, M.; Muinos-Lopez, E.; Lagani, V.; Tegner, J.; Hernaez, M.; Agirre, X.; Ebert, B.; Paiva, B.; Rodriguez-Otero, P.; Tamariz-Amador, L.-E.; San-Miguel, J.; Saez, B.; Martinez-Climent, J. A.; Calvo, I. A.; Gomez-Cabrero, D.; Prosper, F.

10.1101/2024.04.24.589777 — cancer biology — Posted on 2025-05-31

53 A Novel Machine Learning Approach for Tumor Detection Based on Telomeric Signatures

Shah, P.; Sethuraman, A.

10.1101/2025.05.28.656542 — bioinformatics — Posted on 2025-05-31

54 Evidence-driven biases in alternative splicing inferred from NCBI Eukaryotic Genome Annotation Pipeline metadata

de la Fuente, R.; Diaz-Villanueva, W.; Arnau, V.; Moya, A.

10.1101/2025.05.27.656353 — bioinformatics — Posted on 2025-05-31

55 EnhancerDetector: Enhancer Discovery from Human to Fly via Interpretable Deep Learning

Solis, L. M.; Sterling-Lentsch, G.; Halfon, M. S.; Girgis, H. Z.

10.1101/2025.05.28.656532 — bioinformatics — Posted on 2025-05-31

56 MetaFX: feature extraction from whole-genome metagenomic sequencing data

Ivanov, A.; Popov, V.; Morozov, M.; Olekhnovich, E.; Ulyantsev, V.

10.1101/2025.05.27.656413 — bioinformatics — Posted on 2025-05-31

57 Tomtom-lite: Accelerating Tomtom enables large-scale and real-time motif similarity scoring

Schreiber, J.

10.1101/2025.05.27.656386 — bioinformatics — Posted on 2025-05-31

58 Genome sequencing confirms cryptic diversity and potentially adaptive changes in gene content of Lepidoptera-infecting Apicomplexa

Mongue, A. J.; Kuperus, P.; Groot, A. T.

10.1101/2025.05.29.656805 — evolutionary biology — Posted on 2025-05-31

59 Long-term impacts of tree monoculture plantations on biodiversity are mediated by soil acidification

Balestra, S.; Manuzi, V.; Ceresa, E.; Gatti, P.; Pirttilahti, R.; Adatte, T.; Grand, S.; Losapio, G.

10.1101/2025.05.27.656426 — ecology — Posted on 2025-05-31

60 Persistently increased expression of PKMζ and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins

Han, J.; Grau-Perales, A.; Harris, R. M.; Kao, H.-y.; Pal, A.; Alarcon, J.-M.; Sacktor, T. C.; Martiniani, S.; Hofmann, H. A.; Fenton, A. A.

10.1101/2025.04.28.651143 — neuroscience — Posted on 2025-05-31

61 Prenatal Alcohol Exposure Impairs Striatal Cholinergic Function and Cognitive Flexibility in Adult Offspring

Purvines, W.; Gangal, H.; Xie, X.; Ramos, J.; Wang, X.; Miranda, R.; Wang, J.

10.1101/2025.05.27.656351 — neuroscience — Posted on 2025-05-31

62 Decoding Breast Cancer in X-ray Mammograms: A Multi-Parameter Approach Using Fractals, Multifractals, and Structural Disorder Analysis

Maity, S.; Alrubayan, M.; Pradhan, P.

10.1101/2025.05.27.656317 — cancer biology — Posted on 2025-05-31

63 Genomic Insights into a Highly Specific Marine Symbiosis Uncovers Geographic Structuring Without Co-Divergence Between Siphamia Cardinalfish and Their Bioluminescent Symbiont

Neff, E.; Gould, A.

10.1101/2025.05.30.657134 — evolutionary biology — Posted on 2025-05-31

64 Phylogenetic Estimation of branch-specific Shifts in the Tempo of Origination

Kopperud, B. T.; Höhna, S.

10.1101/2025.05.28.656596 — evolutionary biology — Posted on 2025-05-31

65 Avian promiscuity in the last European primeval forest

Sudyka, J.; Di Lecce, I.; Hebda, G.; Rowinski, P.; Rutkowski, R.; Szczuka, A.; Perrier, C.; Cholewa, M.; Maziarz, M.; Wesołowski, T.; Szulkin, M.

10.1101/2025.05.29.656776 — ecology — Posted on 2025-05-31

66 SHOLA SKY ISLANDS BIRD SURVEY 2025

P, S. M.; L, R. R.; K, V. C.; K, S. E.

10.1101/2025.05.29.656751 — ecology — Posted on 2025-05-31

67 What determines trophic niche breadth? A global analysis of freshwater fishes using isospaces

Keppeler, F. W.; Giarrizzo, T.; Montana, C. G.; Adite, A.; Akin, S.; Angelini, R.; Arantes, C. C.; Benedito, E.; Bokhutlo, T.; El-Sabaawi, R.; Garcia, A.; Gonzalez-Bergonzoni, I.; Hoeinghaus, D.; Hoffman, J.; Jensen, O. P.; Jeppesen, E.; Kopf, R. K.; Layman, C. A.; Lopez, E. O.; Maitland, B. M.; Matsuzaki, S.-i. S.; Olin, J. A.; Paterson, G.; Quintana, Y.; Rezende, C. E. d.; Trudeau, A.; Trindade, P. A.; Turner, T. F.; Zandona, E.; Winemiller, K. O.

10.1101/2025.05.27.656387 — ecology — Posted on 2025-05-31

68 How do urban-dwelling bats cope with urbanisation? Sex-dependent plasticity of stress, microbiome and pathogen shedding

Toshkova, N.; Aguillon, S.; Turpin, M.; Lebarbenchon, C.; Dietrich, M.

10.1101/2025.05.27.656307 — ecology — Posted on 2025-05-31

69 Changes over a 10-year Period in the Distribution Ranges and Genetic Hybridization of Three Pelophylax Pond Frogs in Central Japan

Shigeta, S.; Suzuki, T.; Komaki, S.; Tojo, K.

10.1101/2025.05.28.656534 — ecology — Posted on 2025-05-31

70 Tactile and Visual Spatial Frequency Perception Follows Optimal Integration but Is Not Affected by Spatial Proximity

Wang, G.; Alais, D.

10.1101/2025.05.27.656312 — neuroscience — Posted on 2025-05-31

71 Mitochondrial Calcium Uniporter protects hippocampal CA2 neurons from excitotoxic injury

Skweres, A.; Beresewicz-Haller, M.; Basheer, O.; Nalepa, M.; Owczarek, A.; Kawalec, M.; Gruszczynska-Biegala, J.; Zabłocka, B.; Wegrzynowicz, M.

10.1101/2025.05.27.656314 — neuroscience — Posted on 2025-05-31

72 Neural hierarchy for coding articulatory dynamics in speech imagery and production

Zhao, Z.; Wang, Z.; Liu, Y.; Qian, Y.; Yin, Y.; Gao, X.; Yuan, B.; Tong, S. X.; Tian, X.; Chen, G.; Li, Y.; Lu, J.; Wu, J.

10.1101/2025.05.27.656311 — neuroscience — Posted on 2025-05-31

73 SIRT1-IDR-Driven Temporal Gating of Sequential Transcription-Factor Recruitment Coordinates Fasting Adaptation

Shukla, A.; Chakrabarti, S.; Balaji, C.; Kolthur-Seetharam, U.

10.1101/2025.05.27.656293 — physiology — Posted on 2025-05-31

74 The Rationalization of Carbon Monoxide and Hemoglobin Association

Lee, C.; Chen, N.

10.1101/2025.05.27.656340 — physiology — Posted on 2025-05-31

75 A Bayesian Approach for Identifying Driver Mutations within Oncogenic Pathways through Mutual Exclusivity

Wang, X.; Kostrzewa, C.; Reiner, A.; Shen, R.; Begg, C.

10.1101/2025.05.27.656485 — bioinformatics — Posted on 2025-05-31

76 Benchmarking Genomic Variant Calling Tools in Inbred Mouse Strains: Recommendations and Considerations

Garretson, A. C.; Blanco-Berdugo, L.; Roberts, A.; Dumont, B. L.

10.1101/2025.05.28.656711 — bioinformatics — Posted on 2025-05-31

77 Signal peptides as potential structural modulators of human splice isoforms

Tsaban, T.; Schueler-Furman, O.

10.1101/2025.05.27.656295 — bioinformatics — Posted on 2025-05-31

78 Infanticide in a colonial cooperative bird is not associated with direct reproductive benefits

Covas, R.; Silva, L. R.; Ferreira, A. C.; D'Amelio, P. B.; Fortuna, R.; DuVal, D.; Paquet, M.; Doutrelant, C.

10.1101/2025.05.27.656097 — animal behavior and cognition — Posted on 2025-05-31

79 Electroacupuncture promotes post-stroke motor recovery through miR-124-3p-mediated regulation of NRG1/ErbB4 signaling pathway

Yu, D.; Chen, P.; Chen, X.; Lin, F.; Lin, Y.; Chen, N.; Wu, F.; Shao, B.

10.1101/2025.05.27.656264 — animal behavior and cognition — Posted on 2025-05-31

80 Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

Cherry, J. L.

10.1101/2025.05.27.656382 — evolutionary biology — Posted on 2025-05-31

81 An ancient role for conserved innate immunity transcription factors in holobiont self-recognition

Yang, B.; Yuen, B.; Degnan, B. M.; Degnan, S. M.

10.1101/2025.05.27.656460 — evolutionary biology — Posted on 2025-05-31

82 Geometric morphometrics enables accurate predictions of paleoecology and reveals unique adaptations to an expanded niche space in extinct waterfowl

Chatterji, R. M.; Williams, S.; Buckner, J. C.

10.1101/2025.05.29.656821 — evolutionary biology — Posted on 2025-05-31

83 Convergent latitudinal erosion of circadian systems in a rapidly diversifying order of fishes

Wright, D. B.; Zhang, Y.; Daane, J. M.

10.1101/2025.05.28.656707 — evolutionary biology — Posted on 2025-05-31

84 Oxygen as a primary selective pressure for photo-endosymbiosis evolution

Quevarec, L.; Bonnarde, R.; Robaglia, C.; Brasseur, G.

10.1101/2025.05.28.656558 — evolutionary biology — Posted on 2025-05-31

85 Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity.

Fukutomi, Y.; Phillips-Garcia, A.; Liu, J.; Chuang, A.; Watada, M.; Ramniwas, S.; Kopp, A.

10.1101/2025.05.30.657093 — evolutionary biology — Posted on 2025-05-31

86 Climate Change, Fisheries Management, and Increases in Demersal Fish Distribution in a Southern Ocean Biodiversity Hotspot

Williams, J.; Foster, S.; Woolley, S.; Ziegler, P.; Masere, C.; Naughten, K.; Ovaskainen, O.; Johnson, C.; Hill, N.

10.1101/2025.05.27.656478 — ecology — Posted on 2025-05-31

87 Could malaria mosquitoes be controlled by periodic releases of transgenic mosquitocidal Metarhizium pingshaense fungus? A mathematical modeling approach

Pant, B.; Bilgo, E.; Mitra, A.; Safdar, S.; Diabate, A.; St. Leger, R.; Gumel, A. B.

10.1101/2025.05.28.656721 — ecology — Posted on 2025-05-31

88 Estimating the impact of invasive pests and diseases on ecosystem services: modelling carbon sequestration loss due to myrtle rust (Austropuccinia psidii exotic strains) in Australia

Le, T. P.; Theng, M.; Baker, C. M.; Abell, I. R.; Kompas, T.; Hudgins, E. J.

10.1101/2025.05.30.657121 — ecology — Posted on 2025-05-31

89 Delayed effects of water-limiting conditions influence the ramet demography of a native iterocarpic thistle

Mensah, J. N.; Louda, S. M.; Keeler, K. H.; Tenhumberg, B.

10.1101/2025.05.27.656337 — ecology — Posted on 2025-05-31

90 Larval seedboxes: a modular and effective tool for scaling coral reef restoration

Doropoulos, C.; Roff, G.; Carlin, G.; Gouezo, M.; dela Cruz, D.; Chai, A.; Hardiman, L.; Hasson, L.; Thomson, D. P.; Harrison, P. L.

10.1101/2025.05.29.656887 — ecology — Posted on 2025-05-31

91 Microstructural architecture of the argonauts' shell-like eggcase reveals the formation logic of a convergent extended phenotype

Hirota, K.; Sasaki, T.; Yoshimura, T.; Onodera, S.; Hirano, H.; Toyama, T.; Yoshida, M.-a.; Setiamarga, D. H. E.

10.1101/2025.05.27.656349 — zoology — Posted on 2025-05-31

92 Cancer Diagnostics using Machine Learning of Tumor- and Tissue- Specific RNA Transcripts

Chen, Z.; Tang, J.; Li, H.; Chen, Y.; He, X.

10.1101/2025.05.27.656256 — bioinformatics — Posted on 2025-05-31

93 Open-land-derived agroforestry and effects of abandonment of management of the main crop on ecosystem services and woody plant diversity

Fonzaghi, L. M.; Hylander, K.; de Melo, T. S.; Tack, A. J. M.

10.1101/2025.05.27.656282 — ecology — Posted on 2025-05-31

94 Neural integration of acoustic statistics enables detecting acoustic targets in noise

Alishbayli, A.; Przewrocki, K.; van Heumen, P.; Englitz, B.

10.1101/2025.05.29.656794 — neuroscience — Posted on 2025-05-31

95 Adaptive transcranial ultrasound Doppler imaging of the brain

Waasdorp, R.; Munoz-Ibarra, E.; Nelissen, F.; Heiles, B.; Gazzola, V.; Renaud, G. G. J.; Maresca, D.

10.1101/2025.05.27.656275 — neuroscience — Posted on 2025-05-31

96 Gaze dynamics prior to navigation support hierarchical planning

Gordon, J. R.; Chuang, J.; Pezzulo, G.

10.1101/2025.01.16.633460 — neuroscience — Posted on 2025-05-31

97 Age-related Increase in Locus Coeruleus Activity and Connectivity with Prefrontal Cortex during Ambiguity Processing

Dave, A.; Ye, S.; Batz, L. R.; Lan, X.; Jacobs, H.; Ziaei, M.

10.1101/2024.12.21.629084 — neuroscience — Posted on 2025-05-31

98 Cerebellar acceleration of learning in an evidence-accumulation task

Oostland, M.; Kislin, M.; Chen, Y.; Chen, T.; Venditto, S. J. C.; Deverett, B.; Wang, S. S.- H.

10.1101/2021.12.23.474034 — neuroscience — Posted on 2025-05-31

99 The MpCAFA gene encodes a ciliary protein required for spermatozoid motility in the liverwort Marchantia polymorpha

MORITA, M.; Yamato, K. T.

10.1101/2025.04.26.650577 — plant biology — Posted on 2025-05-31

100 Optimizing Oyster Breeding with Machine Learning and BigData for Superior Quality

Nayak, P.; Mishra, R.; Swain, R.; Sahoo, D.

10.1101/2025.05.16.654565 — bioinformatics — Posted on 2025-05-31

101 pLM-SAV: A Δ-Embedding Approach for Predicting Pathogenic Single Amino Acid Variants

Gereben, O.; Tordai, H.; Khamisi, L.; Kouri, A.; Hegedus, T.

10.1101/2025.05.24.655916 — bioinformatics — Posted on 2025-05-31

102 Beyond deep versus superficial: true laminar inference with MEG

Szul, M. J.; Agarwal, I.; Moreau, Q.; Hiba, B.; Bestmann, S.; Barnes, G. R.; Bonaiuto, J. J.

10.1101/2025.05.28.656642 — neuroscience — Posted on 2025-05-31

103 Genome-wide characterization of MLO family in bread wheat shed light on its role in resistance to powdery mildew, biotic and abiotic stresses

Hussain, B.; Ramzan, H.; Raza, Q.; Atif, R. M.; Budak, H.; Ali, Z.

10.1101/2023.09.22.559087 — genomics — Posted on 2025-05-31

104 Altered Hepatic Metabolism in Down Syndrome

Dunn, L. N.; Niemeyer, B. F.; Eduthan, N. P.; Schade, K. A.; Waugh, K. A.; Brown, C.; Rachubinski, A. L.; Timkovich, A. E.; Orlicky, D. J.; Galbraith, M. D.; Espinosa, J. M.; Sullivan, K. D.

10.1101/2025.05.27.656393 — genetics — Posted on 2025-05-31

105 Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in pediatric AML

Schliehe-Diecks, J.; Tu, J.-W.; Stachura, P.; Schaal, K.; Kemkes, M.; Vasileiou, E.; Ruechel, N.; Brandes, D.; Vogt, M.; Lenz, T.; Nair, A.; Scheu, S.; Dominguez, P.; Pastorczak, A.; Nebral, K.; Stuehler, K.; Fischer, U.; Pandyra, A.; Borkhardt, A.; Bhatia, S.

10.1101/2025.05.30.654805 — cell biology — Posted on 2025-05-31

106 Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi

Franco, M. E. E.; Nickerson, M. N.; Bowen, B. M.; Louie, K.; Northen, T.; U'Ren, J. M.

10.1101/2024.12.10.624342 — microbiology — Posted on 2025-05-31

107 Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent

McCausland, J. W.; Kloos, Z. A.; Irnov, I.; Sonnert, N. D.; Zhou, J.; Putnick, R.; Mueller, E. A.; Steere, A. C.; Palm, N. W.; Grimes, C. L.; Jacobs-Wagner, C.

10.1101/2025.01.08.631998 — microbiology — Posted on 2025-05-31

108 An Adipose mTORC1 Effector Links Nutrient-induced Ribosomal Protein Translation to Lifespan in Drosophila

Wang, J.; Cai, Z.; Gu, J.; Yang, M.; Chang, K.; Ning, X.; Wen, Y.; Yan, Y.; Lu, J.; Wang, Y.; Zhai, Z.

10.1101/2025.05.27.656475 — physiology — Posted on 2025-05-31

109 Deciphering lipidomics landscape of urine extracellular vesicles in alcohol use disorder patients

Martin-Urdiales, B.; Perpina-Clerigues, C.; Mellado, S.; Rojas-Pirela, M.; Aguilar Sanchez, M.-L.; Puertas-Miranda, D.; Garcia-Garcia, F.; Marcos, M.; Pascual, M.

10.1101/2025.05.27.656263 — pathology — Posted on 2025-05-31

110 Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells

Anttila, J. M.; Savelius, M.; Somani, J.; Nicorici, D.; Munne, P. M.; Id, L.; Peura, A.; Hiltunen, A. O.; Aung, J.; Awadhpersad, R.; Prajapati, B.; Peltonen, M.; Ala-Hongisto, H.; Gautam, P.; Valimaki, M. J.; Tervonen, T. A.; Sapovalovaite, K.; Devarajan, R.; Perez, M. V. R.; Mutka, M.; Kovanen, P.; Niinikoski, L.; Meretoja, T.; Mattson, J.; Heikkila, P.; Wennerberg, K.; Arsenian-Henriksson, M.; Westermarck, J.; Aittokallio, T.; Goga, A.; Jackson, C. B.; Nieminen, A. I.; Klefstrom, J.

10.1101/2025.05.27.656356 — cancer biology — Posted on 2025-05-31

111 Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

Postlmayr, A.; Sanchez Bergman, A.; Torrejon Diaz, J.; Ciraulo, B.; Yan, S.; Hofmann, N.; Carbajal, S.; Dobler, R.; Machaalani, C.; Priego-Gonzalez, L.; De Micheli, A. J.; Berenjeno-Correa, E.; Baroncini, L.; Grotzer, M. A.; Tabori, U.; Hawkins, C.; Ayrault, O.; Zuckermann, M.; Baumgartner, M.; Guerreiro Stuecklin, A. S.

10.1101/2025.05.27.656302 — cancer biology — Posted on 2025-05-31

112 Efficient and sustained optogenetic control of sensory and cardiac systems

Alekseev, A.; Hunniford, V.; Zerche, M.; Jeschke, M.; El May, F.; Vavakou, A.; Siegenthaler, D.; Hueser, M. A.; Kiehn, S. M.; Garrido-Charles, A.; Meyer, A.; Rambousky, A.; Alvanos, T.; Witzke, I.; Rojas-Garcia, K. D.; Draband, M.; Cyganek, L.; Klein, E.; Ruther, P.; Huet, A.; Trenholm, S.; Mace, E.; Kusch, K.; Bruegmann, T.; Wolf, B. J.; Mager, T.; Moser, T.

10.1101/2023.11.17.567544 — biophysics — Posted on 2025-05-31

113 GETgene-AI: A Framework for Prioritizing Actionable Cancer Drug Targets

Gu, A.; Chen, J. Y.

10.1101/2025.01.21.634201 — bioinformatics — Posted on 2025-05-31

114 Click-qPCR: an ultra-simple tool for interactive qPCR data analysis

Kubota, A.; Tajima, A.

10.1101/2025.05.29.656779 — bioinformatics — Posted on 2025-05-31

115 Parameter-Efficient Fine-Tuning of a Supervised Regulatory Sequence Model

Yuan, H.; Linder, J.; Kelley, D. R.

10.1101/2025.05.26.656171 — bioinformatics — Posted on 2025-05-31

116 A Ratiometric Catalog of Protein Isoform Shifts in the Cardiac Fetal Gene Program

Han, Y.; Binti, S.; Wennersten, S. A.; Pandi, B.; Ng, D. C. M.; Lau, E.; Lam, M. P. Y.

10.1101/2024.04.09.588716 — biochemistry — Posted on 2025-05-31

117 Economic analysis of disease and control of multi-field epidemics in agriculture

Mikaberidze, A.; Gokhale, C. S.; Bargues-Ribera, M.; Verma, P.

10.1101/2023.09.05.556392 — evolutionary biology — Posted on 2025-05-31

118 The evolution of dependence and cohesion in incipient endosymbioses

Athreya, G.; Czuppon, P.; Gokhale, C. S.

10.1101/2023.07.17.549359 — evolutionary biology — Posted on 2025-05-31

119 Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease

Sah, S.; Sauerbeck, A. D.; Gupta, J.; Perez-Acuna, D.; Reiber, J. E.; Russell, D.; Goralski, T.; Henderson, M.; Volpicelli-Daley, L. A.; Higley, M. J.; Kummer, T. T.; Biederer, T.

10.1101/2024.06.20.599774 — neuroscience — Posted on 2025-05-31

120 ElectroPhysiomeGAN: Generation of Biophysical Neuron Model Parameters from Recorded Electrophysiological Responses

Kim, J.; Peng, M.; Chen, S.; Liu, Q.; Shlizerman, E.

10.1101/2023.12.19.572452 — neuroscience — Posted on 2025-05-31

121 Cancer-associated metabolic alterations facilitated by astrocyte glycogenolysis mediate neuropathic pain chronicity

Park, J.; Kim, K.; Jun, H.; Lee, S. J.

10.1101/2025.05.27.655245 — neuroscience — Posted on 2025-05-31

122 Leveraging Dynamic Stability to Infer Regulation in Protein-Protein Interaction Networks: A Study of Infectious Vulnerability in COPD.

Reimer, J.; Page, J.; Saha, P.; Shen, S.; Zhu, X.; Qian, S.; Mammen, M.; Qu, J.; Sethi, S.; Broderick, G. J.

10.1101/2025.05.26.656208 — systems biology — Posted on 2025-05-31

123 Finding an optimal sequencing strategy to detect short and long genetic variants in a human genome

Eveleigh, R. J. M.; Reiling, S. J.; Galvez, J. H.; Bourgey, M.; Ragoussis, J.; Bourque, G.

10.1101/2025.05.30.656631 — genomics — Posted on 2025-05-30

124 The genetic architecture of an allosteric hormone receptor

Stammnitz, M. R.; Lehner, B.

10.1101/2025.05.30.656975 — genomics — Posted on 2025-05-31

125 Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform

McLeod, C. M.; Son, S.; Haque, M. N.; Garrett, A. M.

10.1101/2025.05.29.656828 — neuroscience — Posted on 2025-05-30

126 Long-lasting Avoidance Induced by Repeated Stimulation of the Rostromedial Tegmental Nucleus

Watson, J. R.; Lopez de Leon, M. D.; Carlson, E. L.; Vento, P. J.

10.1101/2025.05.30.657063 — neuroscience — Posted on 2025-05-30

127 Towards model-based design of causal manipulations of brain circuits with high spatiotemporal precision

De, A.; Kiani, R.; Mazzucato, L.

10.1101/2025.05.30.657050 — neuroscience — Posted on 2025-05-30

128 Interpersonal alignment in infra-slow EEG rhythms anticipates mutual recognition

Gravel, N. G.; Froese, T.

10.1101/2025.05.29.656704 — neuroscience — Posted on 2025-05-30

129 The Effects of Early Life Pain and Juvenile Fear Conditioning on CRF-Receptor Expression in the Amygdala and Hypothalamus

Burman, M. A.; Zuke, J. T.

10.1101/2025.05.29.656935 — neuroscience — Posted on 2025-05-30

130 The genetic architecture of G-protein coupled receptor signaling

Mighell, T.; Lehner, B.

10.1101/2025.05.30.656974 — systems biology — Posted on 2025-05-30

131 Epigenetic and evolutionary features of ape subterminal heterochromatin

Yoo, D.; Munson, K. M.; Eichler, E. E.

10.1101/2025.05.29.656835 — evolutionary biology — Posted on 2025-05-30

132 Title: The RNA-binding protein TRIM71 is essential for hearing in humans and mice and regulates the timing of auditory sensory organ development

Li, X.-J.; Li, L.; Morgan, C.; Duy, P. Q.; Evsen, L.; Hao, L. T.; Machavoine, R.; Belhous, K.; Ernest, S.; Denoyelle, F.; Mignot, C.; Brioude, F.; Parodi, M.; Huang, H.; Nadar-Ponniah, P. T.; Kolanus, W.; Kahle, K. T.; Marlin, S.; Doetzlhofer, A.

10.1101/2025.05.29.656801 — neuroscience — Posted on 2025-05-30

133 Modulation of temporal prediction by STN-DBS in Parkinson's disease: Links between behavior and cortical oscillations

Burke, R.; Schoenfeld, M. J.; Moll, C. K. E.; Gulberti, A.; Poetter-Nerger, M.; Engel, A. K.

10.1101/2025.05.29.656824 — neuroscience — Posted on 2025-05-30

134 Neural Onset and Offset Responses in Core and Belt Auditory Cortex of Young and Aged Alert Macaque Monkeys

Lu, D.; Recanzone, G. H.

10.1101/2025.05.29.656850 — neuroscience — Posted on 2025-05-30

135 Investigating milk derived extracellular vesicles as mediators of maternal stress and environmental intervention

Martz, J.; Hammer, B.; Langen, T. J.; Berkowitz, B.; Berkowitz, B.; Storm, J. A.; Lu, J.; Lehri, D.; Wijenayake, S.; Marrocco, J.; Kentner, A. C.

10.1101/2025.05.30.656911 — neuroscience — Posted on 2025-05-30

136 Informed Data-Independent Acquisition Enables Targeted Quantification of Key Regulatory Proteins in Cell Fate Decision at Single-Cell Resolution

Woessmann, J.; Petrosius, V.; Schovsbo, S.; Arrey, T. N.; Furtwaengler, B.; Op de Beeck, J.; Damoc, E.; Porse, B. T.; Schoof, E. M.

10.1101/2025.05.30.656945 — systems biology — Posted on 2025-05-30

137 NAT10 governs uterine function and fertility by stabilizing progesterone receptor mRNA via ac4C modification

Tang, S.; Peng, D.-K.; Jiang, R.-F.; Hong, Y.-Q.; Zhang, Q.-Y.; Yang, X.-Q.; Zhang, A.-N.; Xu, Y.-W.; Yang, S.-H.; Liu, J.-L.

10.1101/2025.05.27.656376 — physiology — Posted on 2025-05-30

138 IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site

Socuellamos, P. G.; Viedma-Barba, C.; de Benito-Bueno, A.; Bonache, M. A.; Ropero, M.; Diez, S.; Elizalde, P.; Marin-Olivero, I.; Redondo-Moya, M.; Naranjo, J. R.; Gonzalez-Vera, J. A.; Orte, A.; Perez-Lara, A.; Martin-Martinez, M.; Valenzuela, C.; Gutierrez-Rodriguez, M.

10.1101/2025.05.29.656781 — pharmacology and toxicology — Posted on 2025-05-30

139 Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity

King, J.; Gisselbrecht, S. S.; Dias, J.-A.; Jeong, R. L.; Rothman, E.; Bulyk, M. L.

10.1101/2025.05.27.656303 — genomics — Posted on 2025-05-30

140 Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes

Ramos-Almodovar, F.; Gao, Z.; Voight, B. F.; Mathieson, I.

10.1101/2025.05.28.656604 — evolutionary biology — Posted on 2025-05-30

141 Prevalence of water and nutrient availability in structuring fungal communities of healthy and decaying beech trees in forests

Fracchia, F.; Dauphin, B.; Walthert, L.; Graf, R.; Koechli, R.; Pfister, S.; Baltensweiler, A.; Kohler, A.; Peter, M.

10.1101/2025.05.27.656299 — ecology — Posted on 2025-05-30

142 Beyond temperature: Relative humidity systematically shifts the temperature dependence of population growth in a malariavector

Huxley, P. J.; Brown, J. J.; St. Laurent, B.; Johnson, B.; Cheung, O. Y.; Asamoah, A.; Hollingsworth, B. D.; Bump, E. R.; Wimberly, M. C.; Pascual, M.; Johnson, L. R.; Murdock, C. C.

10.1101/2025.05.30.656372 — ecology — Posted on 2025-05-30

143 Modulation of error sensitivity during motor learning across time, space and environment variability

Todorov, D. I.; Moulin, M.; Buch, E.; Quentin, R.

10.1101/2025.05.30.656374 — neuroscience — Posted on 2025-05-30

144 Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity.

Markovitsch, J. W.; Mitic, D.; Garcia, A. d. P. J.; Alsberga, Z.; Kainz, S.; Kaur, R.; Hummel, T.

10.1101/2025.05.27.656373 — neuroscience — Posted on 2025-05-30

145 Changing the initiation unit of nonribosomal peptide synthetases to access underexplored biosynthetic potential

Bai, X.; Zhong, L.; Chen, H.; Liu, Y.; Shi, X.; Wang, X.; Yang, Q.; Diao, X.; Wu, D.; Zhang, Y.; Bian, X.

10.1101/2025.05.29.656725 — synthetic biology — Posted on 2025-05-30

146 Real-Time EEG Response to Pulsed Transcranial Photobiomodulation in Healthy Young Adults: Effects of Stimulation Parameters and Skin Tone

Mathew, A.; Van Lankveld, H.; Zhong, X. Z.; Chen, J. X.; Chen, J. J.

10.1101/2025.05.26.656199 — physiology — Posted on 2025-05-30

147 Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

Robertson, M. J.; Papasergi-Scott, M. M.; Peroto, M. C.; Varga, B. R.; Majumdar, S.; Skiniotis, G.

10.1101/2025.05.26.656223 — pharmacology and toxicology — Posted on 2025-05-30

148 Garcinone C suppressed the proliferation of gastric cancer cells through regulating Hedgehog signaling

Zhou, Y.; Kim, J. T.; Kwon, J. W.; Lee, G. Y.; Son, H. M.; Lee, K. H.; Qiu, S.; Lee, H. J.

10.1101/2025.05.26.655423 — cancer biology — Posted on 2025-05-30

149 LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance

Hovey, O. F.; Frederick, M. I.; Quach, Q. M.; Kakadia, J. H.; Wu, A.; Yang, K.; Wu, T.; Ruan, X.; Kaneko, T.; Voss, C.; Heinemann, I. U.; Li, S. S.

10.1101/2025.05.30.652226 — cancer biology — Posted on 2025-05-30

150 Unpaired Image-to-Image Translation for Segmentation and Signal Unmixing

Andrejic, N.; Spasic, M.; Mihajlovic, I.; Milosavljevic, P.; Pavlovic, D.; Milisavljevic, F.; Milivojevic, U.; Delibasic, D.; Mikic, I.; Todorovic, S.

10.1101/2025.05.26.656226 — bioinformatics — Posted on 2025-05-30

151 Transgenic Bax gene efficiently induces lethality in mouse early embryos

Goto, Y.; Yamamoto, T.; Sakata, M.; Mashiko, S.; Shikata, D.; Honda, S.; Minami, N.; Ikeda, S.

10.1101/2025.05.26.656236 — bioengineering — Posted on 2025-05-30

152 Streamlined isolation of the n-terminome via phosphonate tagging and coordination-based depletion

Giansanti, P.; Fojnica, A.; Pichlmair, A.

10.1101/2025.05.30.657046 — biochemistry — Posted on 2025-05-30

153 Neurons accumulate disease-specific somatic genomic changes across taupathologic states in Alzheimer's disease

Jin, B.; Brown, K. S.- M.; Smirnov, D. S.; Naik, S. M.; Kirkham, S. L.; Hennessey, E. L.; Dong, G.; Mao, S.; Wijethunga, S. P.; Stewart, T. C.; Selkoe, D. J.; Frosh, M. P.; Oakley, D. H.; Hyman, B. T.; Huang, A. Y.; Miller, M.

10.1101/2025.05.26.656152 — genomics — Posted on 2025-05-30

154 Tac1 Deficiency Reduces the Severity of Enteric Bacterial Infection

Lloyd, E.; Cremin, M.; Sanchez, K.; Park, J.; Gareau, M. G.; Reardon, C.

10.1101/2025.05.27.656414 — immunology — Posted on 2025-05-30

155 Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from aged hosts against antibody opsonized Streptococcus pneumoniae

Simmons, S. R.; Rivera, A.; Ghanem, E. N. B.

10.1101/2025.05.27.656427 — immunology — Posted on 2025-05-30

156 Manifold learning for olfactory habituation to strongly fluctuating backgrounds

Bourassa, F. X. P.; Francois, P.; Reddy, G.; Vergassola, M.

10.1101/2025.05.26.656161 — neuroscience — Posted on 2025-05-30

157 Ninjurin2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling through Interacting with PDGF Receptor-β

Jia, M.; Zhuo, J.; Zhao, X.; Liu, T.; Zhang, H.; Xu, K.; Wang, P.; Xu, C.

10.1101/2025.05.27.656052 — pathology — Posted on 2025-05-30

158 Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator

10.1101/2025.05.29.656244 — cancer biology — Posted on 2025-05-30

159 scCoBench: Benchmarking single cell RNA-seq co-expression using promoter-reporter lines

Chau, T. N.; Ryu, K. H.; Alajoleen, R.; Bargmann, B. O. R.; Schiefelbein, J.; Li, S.

10.1101/2025.05.26.656221 — bioinformatics — Posted on 2025-05-30

160 How Good is AlphaFold3 at Ranking Drug Binding Affinities?

Hong, X.; Gao, B.; Jia, Y.; Zhu, W.; Chen, Q.; Tian, X.; Zhong, Z.; Wang, J.; Lan, Y.

10.1101/2025.05.27.656341 — bioinformatics — Posted on 2025-05-30

161 Rapid adaptive optics enabling near noninvasive high-resolution brain imaging in awake behaving mice

SHE, Z.; Fu, Y.; HE, Y.; Yan, G.; WU, W.; Qin, Z.; Qu, J.

10.1101/2025.05.26.656230 — bioengineering — Posted on 2025-05-30

162 FDA drug repurposing uncovers modulators of dopamine D2 receptor localization via disruption of the NCS-1 interaction

Munoz-Reyes, D.; Aguado, L.; Arroyo-Urea, S.; Requena, C.; Perez-Suarez, S.; Sanchez-Yepes, S.; Argerich, J.; Miro-Rodriguez, C.; Ulzurrun, E.; Rodriguez, E.; Garcia-Nafria, J.; Campillo, N. E.; Mansilla, A.; Sanchez-Barrena, M. J.

10.1101/2025.05.29.656787 — biochemistry — Posted on 2025-05-30

163 Enzymatic Glycosylation of Anthranilates for Enhanced Functionality

Gharabli, H.; Kohler, A. M.; Chiesa, C.; Wagle, S.; Mejia-Otalvaro, F.; Orth, J. V.; Bidart, G. N.; Enevoldsen, A. D.; Förster, J.; Werner, S. J.; Welner, D. H.

10.1101/2025.05.29.656899 — biochemistry — Posted on 2025-05-30

164 Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4

Zhan, J.; Hsieh, C.-M.; Esser, L.; Lang, Z. C.; Morton, A. J.; Robey, R. W.; Zhou, F.; Ambudkar, S. V.; Huang, R. K.; Gottesman, M. M.; Xia, D.

10.1101/2025.05.30.656806 — biochemistry — Posted on 2025-05-30

165 Genomic and evolutionary factors influencing the prediction accuracy of optimal growth temperature in prokaryotes

Toki, S.; Matsui, M.; Tominaga, K.; Suzuki, T. K.; Tsuchimatsu, T.; Iwasaki, W.

10.1101/2025.05.30.656958 — genomics — Posted on 2025-05-30

166 Phased epigenomics and methylation inheritance in a historical Vitis vinifera hybrid

Cochetel, N.; Vondras, A.; Figueroa-Balderas, R.; Liou, J.; Peluso, P.; Cantu, D.

10.1101/2025.05.27.656431 — genomics — Posted on 2025-05-30

167 Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration

Rubin, J. D.; Ayasoufi, K.; McGlinch, E. B.; Hansen, M. J.; Harris, P. C.; Torres, V. E.; Barry, M. A.

10.1101/2025.05.28.656514 — genetics — Posted on 2025-05-30

168 FtsW protein-protein interactions visualized in live Staphylococcus aureus cells by FLIM-FRET

Meiresonne, N. Y.; Costa, S. F.; Schaeper, S.; Ferreira, M. J.; Reed, P.; Hensel, Z.; Fernandes, F.; Pinho, M. G.

10.1101/2025.05.30.657058 — microbiology — Posted on 2025-05-30

169 A Platinum Butterfly Effect: Small Changes Turn an Anticancer Drug into a Non-toxic Metalloantibiotic with In Vivo Efficacy

Oezsan, C.; Schaefer, A.-B.; Akhir, A.; Aning, O. A.; Fulgencio, S.; Maitra, R.; Rani, R.; Saxena, D.; Westerlund, F.; Chopra, S.; Wenzel, M.; Frei, A.

10.1101/2025.05.30.657029 — microbiology — Posted on 2025-05-30

170 Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads

Lund, G. A.; Mosquito, S.; Withall, D.; Caulfield, J.; Hughes, D.; Clark, I. M.; Rudd, J.; Mauchline, T.

10.1101/2025.05.30.657047 — microbiology — Posted on 2025-05-30

171 A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress

Huang, Y.; Wang, Y.; Pan, M.; Wan, D.; Wang, L.; Fondell, J. D.; Wu, X.; Zhong, G.; Fan, H.

10.1101/2025.05.30.657042 — microbiology — Posted on 2025-05-30

172 Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults.

Kimbler, A.; Stark, C. E. L.

10.1101/2025.05.26.656181 — neuroscience — Posted on 2025-05-30

173 Your Brain Doesn't Look a Day Past 70! Cross-Sectional Associations with Brain-Predicted Age in the Cognitively-Intact Oldest-Old

Britton, M. K.; Hoogerwoerd, H.; Juhasz, J.; Johnson, K. J.; Stewart, P. D.; Merritt, S. S.; Jessup, C. J.; Wright, C. B.; Raichlen, D. A.; Hishaw, G. A.; Del Bene, V. A.; Wadley, V. G.; Trouard, T. P.; Alperin, N.; Levin, B. E.; Rundek, T.; Visscher, K. M.; Alexander, G. E.; Cohen, R. A.; Porges, E. C.; Gullett, J. M.

10.1101/2025.05.26.655855 — neuroscience — Posted on 2025-05-30

174 Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation

Ihrig, C. M.; Pierre, C. J.; Azeez, T. A.; La Favor, J. D.

10.1101/2025.05.26.656242 — physiology — Posted on 2025-05-30

175 Attrition Rates in Mindfulness-Based Interventions for Chronic Pain: A Meta-Analysis

Wang, M. Y.; Perera, M. P.; Fitzgerald, P. B.; Bailey, N.; Fitzgibbon, B. M.

10.1101/2025.05.26.656251 — pathology — Posted on 2025-05-30

176 A Diffusion-Based Framework for Designing Molecules in Flexible Protein Pockets

Wang, J.; Dokholyan, N. V.

10.1101/2025.05.27.656443 — bioinformatics — Posted on 2025-05-30

177 The modular evolution of multiheme cytochromes c bucks the general trend observed in proteins

Soares, R.; Paquete, C. M.; Louro, R. O.

10.1101/2025.05.29.656830 — biochemistry — Posted on 2025-05-30

178 Harnessing photosynthetic ATP for whole-cell biocatalysis in the cyanobacterium Synechocystis

Loprete, G.; Traverso, E.; Vascon, F.; Botteri, M.; Robescu, M. S.; Ubiali, D.; Cendron, L.; Morosinotto, T.; Bergantino, E.

10.1101/2025.05.29.656799 — biochemistry — Posted on 2025-05-30

179 A Chemical Mechanistic Path Leads the Way to Cellular Argpyrimidine

Pham, V. T. T.; Datta, S.; Sterling, A. C.; Hansel, S. M.; Scheck, R. A.

10.1101/2025.05.30.657038 — biochemistry — Posted on 2025-05-30

180 Context-Dependent Variability Of HIF Heterodimers Influences Interactions With Macromolecular And Small Molecule Partners

Closson, J. D.; Xu, X.; Zhang, M.; Tiyani, T. T.; Marcelino, L. P.; Isiorho, E. A.; Nagati, J. S.; Garcia, J. A.; Gardner, K. H.

10.1101/2025.05.29.656908 — biochemistry — Posted on 2025-05-30

181 Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions

Yampolskaya, M.; Mehta, P.; Ikonomou, L.

10.1101/2025.05.27.656406 — biophysics — Posted on 2025-05-30

182 Plectin affects cell viscoelasticity at small and large deformations

Conboy, J. P.; Lettinga, M. G.; van Vliet, N.; Winter, L.; Wiche, G.; MacKintosh, F. C.; Koenderink, G. H.

10.1101/2025.05.28.656588 — biophysics — Posted on 2025-05-30

183 A Mechanical Logic for Bacterial Navigation

Zeng, R.; Sacanna, S.; Saurabh, S.

10.1101/2025.05.27.656390 — biophysics — Posted on 2025-05-30

184 SenolyticSynergy: An Attention-Based Network for Discovering Novel Senolytic Combinations via Human Aging Genomics

Ye, Y.; Ming, D.

10.1101/2025.05.28.655258 — bioinformatics — Posted on 2025-05-30

185 Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core

Nadwa, H.; Brotzakis, Z. F.; Santucci, A.; Braconi, D.; Vendruscolo, M.

10.1101/2025.05.27.656333 — biochemistry — Posted on 2025-05-30

186 Membrane remodeling by the Bacterial Dynamin-like Protein (BDLP) from Nostoc punctiforme

Singh, K.; Pucadyil, T.

10.1101/2025.05.27.656310 — biochemistry — Posted on 2025-05-30

187 Dried Blood Spot Lipidomics in Diabetes

Roberts, J. L.; Ryan, M.; Whiley, L.; Gray, N.; Gay, M.; Holmes, E.; Nicholson, J. K.; Wist, J.; Lawler, N. G.

10.1101/2025.05.28.656742 — biochemistry — Posted on 2025-05-30

188 Spatiotemporal dynamics of cryptococcal infection reveal novel immune modulatory mechanisms and antifungal targets

Woods, M.; Muselius, B. L.; McAlister, J. A.; Ball, B.; Segeren, L.; Chan, N.; Silva, M.; Gutierrez-Gongora, D.; Ramezanpour, S.; Gill, S.; Pundir, P.; Deyarmin, J.; Hakimi, A.; Hermanson, D.; Richter, J.; Samra, S. N.; Geddes-McAlister, J.

10.1101/2025.05.30.657021 — microbiology — Posted on 2025-05-30

189 Quantitative proteomics and phosphoproteomics analyses identify sex-biased protein ontologies of S. japonicum

Fang, C.; Giri, B.; Cheng, G.

10.1101/2025.05.30.656995 — microbiology — Posted on 2025-05-30

190 Multiomics Reveals Compartmentalized Immune Responses and Tissue-Vascular Signatures in Lyme Disease

Rostomily, C.; Bhalla, A.; Hampton, H.; Pflieger, L.; Brunkow, M. E.; Cooper, D.; Lausted, C.; Akhade, A. S.; Smith, B.; Scherler, K.; Troisch, P.; Wang, K.; Wormser, G.; Rappaport, N.; Hood, L.; Subramanian, N.

10.1101/2025.05.27.656061 — immunology — Posted on 2025-05-30

191 Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma

Wang, X.; Duong, L.; Qin, Y.; Parrotta, R.; Purohit, P. K.; Fang, Y.; Liu, G.; He, J.; Wen, J.; Liu, Y.; Zhang, Y.; Zhao, J.; Schafer, Z. T.; Lu, X.; Szegezdi, E.; Lu, X.

10.1101/2025.05.29.621197 — cancer biology — Posted on 2025-05-30

192 Low-Power Acoustic Trapping and Illumination Optimization of Cyanobacteria by Acoustic Layering in Photobioreactors

Dupont, B.; Benoit-Gonin, X.; Vincent-Bonnieu, S.; Aider, J.-L.; Ardre, M.

10.1101/2025.05.27.656267 — biophysics — Posted on 2025-05-30

193 Comparative Evaluation of Three Calcium Silicate-Based Materials for Direct Pulp Capping: An In Vivo Study in Mice.

Fenesha, F.; Phanrungsuwan., A.; Kanniard, D.; Foster, B. L.; Diogenes, A.; Peters, S. B.

10.1101/2025.05.29.656939 — bioengineering — Posted on 2025-05-30

194 Engineered yeast biofilms deliver plastic degrading enzymes to PET substrates

Bilsby, C. R.; Hobbs, S. K.; Davis, J.; Jones, S. M.; Laissue, P. P.; Graham, R.; Deshmukh-Reeves, E.; Sanami, S.; Issa, N.; Xue, W.-F.; Lawrence, A.; Gourlay, C.; Pickford, A. R.; von der Haar, T.

10.1101/2025.05.27.655536 — bioengineering — Posted on 2025-05-30

195 A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product

Brutus, M. E.; Girard, C. S.; Jacob-Dolan, J. W.; Scheck, R. A.

10.1101/2025.05.27.656459 — biochemistry — Posted on 2025-05-30

196 Immunoblot-based activity assay for heme-containing histidine kinases

Larson, G.; Bhagi-Damodaran, A.; Rama Damodaran, A.

10.1101/2025.05.28.656737 — biochemistry — Posted on 2025-05-30

197 Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions

Elgeti, M.; Belyaeva, J.; Helabad, M. B.; Staus, D. P.; Wingler, L. M.

10.1101/2025.05.28.656666 — biochemistry — Posted on 2025-05-30

198 Impact of Peptide Initial Configuration and Membrane Composition on Melittin's Pore-Forming Ability under Unbiased All-Atom Molecular Dynamics Simulations

Zhao, Z.; Guo, Y.; Cai, J.; Xie, P.; Guan, J.; Yao, L.; Liu, Y.; Chung, C.-R.; Lee, T.-Y.; Chiang, Y.-C.

10.1101/2025.05.28.656502 — biochemistry — Posted on 2025-05-30

199 Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity

Dzieciatkowska, M.; Hay, A.; Issaian, A.; Keele, G. R.; Bevers, S.; Nemkov, T.; Reisz, J. A.; Maslanka, M.; Stephenson, D.; Moore, A.; Deng, X.; Stone, M.; Hansen, K.; Kleinman, S.; Norris, P. J.; Busch, M. P.; Page, G. P.; Roubinian, N. H.; Xia, Y.; Zimring, J. C.; D'Alessandro, A.

10.1101/2025.05.27.656446 — biochemistry — Posted on 2025-05-30

200 Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast cancer peritumoral microenvironments

Najera, J.; Chen, H.; Batista, B.; Ketchum, F.; Ali, A.; Zorlutuna, P.; Howard, S.; Datta, M.

10.1101/2025.05.28.656717 — biochemistry — Posted on 2025-05-30

201 Neuroligin 3 highlights sexually dimorphic circuitry in Drosophila social spacing

Robinson, J. W.; Bechard, A. T.; Evans, M. R.; Kurbaj, J.; Mosuro, K.; Isaacson, J. R.; Pillay, S.; Lin, D. S.; Sahota, A.; de Belle, J. N.; Robinson, G. I.; Moehring, A. J.; Simon, A. F.

10.1101/2024.10.28.620699 — animal behavior and cognition — Posted on 2025-05-30

202 Did Iron Suppress Eukaryote Emergence and Early Radiation?

Adam, Z. R.; Slotznick, S.; Bauer, A. Z.; Stewart, E.; Roden, E.; Peters, S.; Konhauser, K.; Kacar, B.

10.1101/2025.05.29.655150 — evolutionary biology — Posted on 2025-05-30

203 Landscape configuration and community structure jointlydetermine the persistence of mutualists under habitat loss

Bhandary, S.; Gawecka, K. A.; Pedraza, F.; Bascompte, J.

10.1101/2025.05.28.655631 — ecology — Posted on 2025-05-30

204 Hidden viral players: Diversity and ecological roles of viruses in groundwater microbiomes

Pratama, A. A.; Perez-Carrascal, O.; Sullivan, M. B.; Kusel, K.

10.1101/2025.05.30.656956 — microbiology — Posted on 2025-05-30

205 Superior intracellular detection of cytokines, transcription factors, and phosphoproteins by CyTOF compared with fluorescent cytometry

Cohen, M.; Smith-Mahoney, E.; Bailey, M.; Wang, L.; Tracey, L.; Polanco, L.; King, D.; Loh, C.; Cappione, A.; Belkina, A.; Snyder-Cappione, J. E.

10.1101/2025.05.30.656809 — immunology — Posted on 2025-05-30

206 Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques

Issah, Y. A.; Hu, X.; Isaac, J.; Shen, X.; Davis, D.; Ozorowski, G.; Sewall, L. M.; Zhang, S.; Kang, E.; Vuong, K.; Dennis, M.; Chen, J.-l.; Ramos, J. M.; Yasmeen, A.; Eudailey, J.; Cupo, A.; Weinbaum, C.; Gao, H.; Stanfield-Oakley, S.; Ferrari, G.; Klasse, P. J.; Fouda, G.; Hudgens, M.; Ward, A. B.; Montefiori, D. C.; Sanders, R. W.; Moore, J. P.; Van Rompay, K. K. A.; De Paris, K.; Permar, S. R.; Nelson, A. N.

10.1101/2025.05.27.656273 — immunology — Posted on 2025-05-30

207 Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-derived Suppressor Cells

Charles, A. M.; Darden, D. B.; Rodhouse, C. E.; Hernandez-Rios, M.; Gauthier, M.-P. L.; Brant, J. O.; Bacher, R. L.; Mathews, C. E.; Moldawer, L. L.; Efron, P. A.; Maile, R.; Kladde, M. P.

10.1101/2025.05.26.656229 — immunology — Posted on 2025-05-30

208 Expanded adaptive NKG2C+ NK cells exhibit potent ADCC and functional responses against HBV-infected hepatoma cell lines

Kokici, J.; Arellano-Ballestero, H.; Hammond, B.; Preechanukul, A.; Hussain, N.; da Costa, K.; Davies, J.; Mukhtar, S.; Fernandez, T.; Kinloch, S.; Burns, F. M.; Kennedy, P.; MacDonald, D.; Maini, M. K.; Gill, U. S.; Zhuang, A. X.; Lowdell, M. W.; Malmberg, K.-J.; Sohlberg, E.; Peppa, D.

10.1101/2025.05.29.655595 — immunology — Posted on 2025-05-30

209 A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages

Palmer, O. G.; Perreard, L.; Kolling, F. W.; Pioli, P. A.; Goods, B. A.

10.1101/2025.05.30.655544 — immunology — Posted on 2025-05-30

210 De novo design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute

Nabla Bio, ; Biswas, S.

10.1101/2025.05.28.656709 — synthetic biology — Posted on 2025-05-30

211 Membrane Interfacial Potential Governs Surface Condensation andFibrillation of α-Synuclein in Neurons

SHAIKH, J.; Nagarajan, A.; Mitra, T.; Modak, A. S.; Biswas, K.; Meher, G.; Bhausaheb, A. J.; Kannan, N. A.; Sahu, B. S.; Ghatak, S.; Choubey, S.; Saleem, M.

10.1101/2025.05.30.657012 — biophysics — Posted on 2025-05-30

212 Initiator and Elongator tRNA Recognition Mechanism in Mycobacterium tuberculosis Methionyl-tRNA Synthetase

THAKUR, S.; Mehra, R.

10.1101/2025.05.27.656506 — biophysics — Posted on 2025-05-30

213 TRIC-Based High-Throughput Screening Enables the Discovery of Small Molecule CD28 Binders

Calvo-Barreiro, L.; Gabr, M.

10.1101/2025.05.27.656499 — biophysics — Posted on 2025-05-30

214 Dual-Axial Force Measurements of Non-Tethered Plants

Ohad, A.; Meroz, Y.

10.1101/2025.05.29.656568 — biophysics — Posted on 2025-05-30

215 Nanopore Assay for Fingerprinting DNA Binding and Quantifying Real-Time Cleavage by Catalytically Active Cas9 Enzyme

Nagpure, P.; Suresh, S.; Shet, D.; Soni, G. V.

10.1101/2025.05.30.656938 — biophysics — Posted on 2025-05-30

216 Co2+-mediated adsorption facilitates atomic force microscopy of DNA molecules at double-helix resolution

Pailing, M.; Maia de Oliveira, T.; Flocco, M.; Hoogenboom, B. W.

10.1101/2025.05.29.655787 — biophysics — Posted on 2025-05-30

217 Comparative efficacy of multi micro-stimulation alveolar (MMSA) and traditional vacuum therapy on skin biomechanics integrity, and inflammation

Chlasta, J.; Tudico, G.; Rolland, J.; Runel, G.; Tudico, F.

10.1101/2025.05.27.656323 — biophysics — Posted on 2025-05-30

218 Parameter-Efficient Fine-Tuning of a Supervised Regulatory Sequence Model

Yuan, H.; Linder, J.; Kelley, D. R.

10.1101/2025.05.26.656171 — bioinformatics — Posted on 2025-05-30

219 Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

Habeck, M.; Saleem, H. N.; Plota, D.; Cheruiyot, C.; Kohl, T.; Jakobs, S.; Lehnart, S. E.; Ebert, A.

10.1101/2025.05.28.655290 — bioinformatics — Posted on 2025-05-30

220 Disease-causing mutations in the G protein β5 β-propeller disrupt its chaperonin-mediated folding trajectory

Sass, M. I.; Mack, D. C.; Nickles, R. A.; Jones, C. A.; Brunsdale, R. L.; Cottam, S. L.; Shen, P. S.; Willardson, B. M.

10.1101/2025.05.28.656654 — biochemistry — Posted on 2025-05-30

221 Rational design of tertiary coordination sphere of a heme-based sensor for two-orders enhanced oxygen affinity

Damodaran, A. R.; Yee, E.; Khade, R. L.; Williams, M.; Apiche, E. A.; Wilson, R. H.; Hoey, E.; Larson, G.; Shi, K.; Aihara, H.; Zhang, Y.; Bhagi-Damodaran, A.

10.1101/2025.05.27.656425 — biochemistry — Posted on 2025-05-30

222 The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

Roeselova, A.; Shivakumaraswamy, S.; Jurkeviciute, G.; He, J.-Z.; Auburger, J.; Schmitt, J.; Kramer, G.; Bukau, B.; Enchev, R. I.; Balchin, D.

10.1101/2025.05.27.656346 — biochemistry — Posted on 2025-05-30

223 Detection of a hybrid PrPfr state in the dark reversion of abathy phytochrome indicates inter-dimer allostery.

Prodhan, S.; Meszaros, P.; Bodizs, S. A.; Zhou, Y.; Maj, M.; Westenhoff, S.

10.1101/2025.05.28.656462 — biochemistry — Posted on 2025-05-30

224 Development and validation of a precise and accurate method to determine polyamine levels in cultured cells.

Cabrera, D.; Pujana Vaquerizo, M.; Martinez La Osa, B.; Zabala Letona, A.; Manuel Falcon, J.; Carracedo, A.; van Liempd, S.

10.1101/2025.05.29.654479 — biochemistry — Posted on 2025-05-30

225 Photopharmacology in Action: Conformational Landscape of a Photoswitchable Covalent Kinase Inhibitor

Duve, T.; Thallmair, S.

10.1101/2025.05.27.656308 — biochemistry — Posted on 2025-05-30

226 A caspase-1-cathepsin AND-gate probe for selectiveimaging of inflammasome activation

Chen, S.; Goncin, U.; Zhu, J.; Su, S.-P.; Czyzyk, T. A.; Miller, C. O.; Kashfi Sadabad, R.; Bogyo, M.

10.1101/2025.05.27.656501 — biochemistry — Posted on 2025-05-30

227 Predictable modulation of a spontaneous post-translational modification in living cells

Martin, M. S.; Bayaraa, N.; Fox, B.; Lin, Y.-S.; Scheck, R. A.

10.1101/2025.05.28.656619 — biochemistry — Posted on 2025-05-30

228 Molecular dynamics simulations reveal the impact of Ser295 phosphorylation on the structure of pyrin domain-containing NOD-like receptor 3

Sandall, C. F.; MacDonald, J. A.

10.1101/2025.05.28.656610 — biochemistry — Posted on 2025-05-30

229 Hsp90-dependent triage of the glucocorticoid receptor via the CHIP E3 ubiquitin ligase

Chio, C. M.; Noddings, C. M.; Wang, F.; Agard, D. A.

10.1101/2025.05.28.656676 — biochemistry — Posted on 2025-05-30

230 RNA binding regulation is a new dimension in the type I IFN response

Iselin, L.; Demyanenko, Y.; Palmalux, N.; Embarc Buh, A.; Kamel, W.; Simmonds, P.; Mohammed, S.; Castello, A.

10.1101/2025.05.30.656608 — biochemistry — Posted on 2025-05-30

231 Gyne production is regulated by the brood in a social bee (Bombus impatiens)

Amsalem, E.; Santos, P. K. F.; Messner, E.; Murray, C. S.

10.1101/2022.07.04.498320 — evolutionary biology — Posted on 2025-05-30

232 A chromosome-length reference genome for the common side-blotched lizard Uta stansburiana and gene expression data reveals fast pace-of-life comes with environmental stability

Fellows, S.; Araya-Donoso, R.; Davalos-Dehullu, E.; Khan, R.; Weisz, D.; Dudchenko, O.; Aiden, E. L.; Munguia-Vega, A.; Dolby, G. A.; Edwards, D. L.

10.1101/2025.05.28.656178 — evolutionary biology — Posted on 2025-05-30

233 Adaptation and trade-offs with insecticide resistance in overwintering Drosophila

Prileson, E. G.; Campagnari, B.; Clare, C. I.; Gabidulin, A. R.; Shahmohamadloo, R. S.; Rudman, S. M.

10.1101/2025.05.27.655643 — evolutionary biology — Posted on 2025-05-30

234 Structural innovations and neurogenic continuity define avian brain development and evolution

Shan, H.; Mei, Y.; Feng, Z.; Gu, X.; Huang, L.; Hui, Y.; Li, C.; Zhou, Y.; He, J.; Wu, R.; Zhuang, Z.; Wang, M.; Chen, D.; Wu, Y.; Zhang, L.; Jia, G.

10.1101/2025.05.30.654767 — evolutionary biology — Posted on 2025-05-30

235 Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimised phage isolation

Tong, E. J.; Bickerton, K. A.; Creber, A. J.; Porter, S. J.; Temperton, B.

10.1101/2025.05.30.656992 — microbiology — Posted on 2025-05-30

236 Small ORF16 modulates the Mtr complex activity in Methanosarcina mazei Goe1 depending on the molecular hydrogen availability

Habenicht, T.; Hastedt, B.; Cassidy, L.; Kiessling, C.; Tholey, A.; Schuller, J. M.; Schmitz, R. A.

10.1101/2025.05.30.657017 — microbiology — Posted on 2025-05-30

237 IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19

Ramon Vazquez, A.; Skowyra, A.; Crowley, T.; Velmurugan, J.; Lee, C.; Lindsay, A. J.; Woznicki, J. A.; Stamou, P.; Nelson, O.; Jeffery, I. B.; Lohan, A. J.; Albrich, W. C.; O Mahony, L.; Melgar, S.; Shanahan, F.; Cao, X.; Macoritto, M.; Sadhukhan, R.; Levesque, M. C.; McRae, B. L.; Matzelle, M.; Nally, K.

10.1101/2025.05.29.656795 — immunology — Posted on 2025-05-30

238 A Ventromedial Hypothalamic Neuron Subset Encodes a Conspecific-Tuned Behavior State Driving Social Investigation

Lin, S.-C. A.; Hsu, J.-Y.; Su, T.-A.; Lee, H.-Z.; Yang, S.-B.

10.1101/2025.05.30.650902 — neuroscience — Posted on 2025-05-30

239 Prenatal alcohol exposure promotes nerve injury-induced pathological pain following morphine treatment via NLRP3-mediated peripheral and central proinflammatory immune actions.

Noor, S. A.; Pasmay, A. A.; Pritha, A. N.; Carter, J.; Jones, A.; Fernandez-Oropeza, A. K.; Sun, M. S.; Jimenez, D. C.; Murphy, M.; Valenzuela, C. F.

10.1101/2025.05.30.655639 — neuroscience — Posted on 2025-05-30

240 Cold-induced suppression of myogenesis in skeletal muscle stem cells contributes to delayed muscle regeneration during hibernation

Miyaji, T.; Kasuya, R.; Monden, M.; Tamura, Y.; Tsukuamoto, D.; Li, G.; Kawano, S.; Watanabe, Y.; Yamaguchi, Y.; Watanabe, M.; Miyazaki, M.

10.1101/2025.05.30.654444 — physiology — Posted on 2025-05-30

241 A Plasma Membrane Vesicle Imaging-Based Platform for Studying Membrane Fusion

Yosibash, I.; Khan, S.; Lichtenstein, A.; Dharan, R.; Vaknin, A.; Daniel, S.; Avinoam, O.; Sorkin, R.

10.1101/2025.05.29.656808 — biophysics — Posted on 2025-05-30

242 Hydrolysis-dependent severing tunes internal monomeric heterogeneity to shape actin length distributions

Ray, S.; Banerjee, B.; Mohapatra, L.; Das, D.

10.1101/2025.05.29.656816 — biophysics — Posted on 2025-05-30

243 Structural insights into the recruitment of viral Type 2 IRES to ribosomal preinitiation complex for protein synthesis

Das, D.; Hussain, T.

10.1101/2025.05.28.656627 — biophysics — Posted on 2025-05-30

244 Multi-spectral optoacoustic microscopy driven by gas-filled hollow-core fiber laser pulses

Zhang, C.; Meneghetti, M.; Antonio-Lopez, J. E.; Amezcua-Correa, R.; Wang, Y.; Markos, C.

10.1101/2025.05.27.656278 — biophysics — Posted on 2025-05-30

245 REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers

Sezgin, Y.; Snyder, G.; Saljoughian, N.; Maguire, C.; Erzurumluoglu Gokalp, E.; Jaganathan, D.; D'ambrossio, E. S.; Ozes, B.; Wheeler, G.; Kelly, B.; Hester, M.; Sahenk, Z.; Vaidyanathan, S.; Rashnonejad, A.; Mendell, J.; Saad, N. Y.; Abraham, R. S.; Bagaitkar, J.; Reynolds, S. D.; Bradbury, A.; Naeimi Kararoudi, M.

10.1101/2025.05.29.641201 — genetics — Posted on 2025-05-30

246 Inhibition of p38 MAPK after repetitive mild TBI ameliorates immune signaling and behavioral deficits

Li, C.; Triplett, S. E.; Griffin, M.; Silverio, A.; Pettit, E.; Rohrer, A.; Callaway, J.; Munagapati, P.; Saah, P.; Sanz, P.; Rivera Moctezuma, F.; Buckley, E.; Wood, L. B.

10.1101/2025.05.29.656410 — molecular biology — Posted on 2025-05-30

247 Anellovirus protein coded by ORF2/3 recruits host cell replication andhomologous recombination machinery during replication

Boisvert, N.; Thurmond, S.; Elenberger, C.; Jeraldo, P.; Prince, C.; Sutherland, N.; Melo, J.; Tsheowang, K.; Dodier, C.; Nogalski, M.; Verma, D.; Parsons, G. B.; Cabral, J.

10.1101/2025.05.28.656439 — molecular biology — Posted on 2025-05-30

248 BRD4 binds the nucleosome via both histone and DNA interactions

Zhu, J.; Leith, E. M.; O'Donnell, E. N.; Manzano, B. P.; Wu, S.-Y.; Chiang, C.-M.; Armache, J.-P.; Tan, S.

10.1101/2025.05.29.656846 — molecular biology — Posted on 2025-05-30

249 CryoEM structure of the central apparatus of the Trypanosoma brucei flagellum

Kashyap, S.; Xia, X.; Wang, H.; Shimogawa, M. M.; Agnew, A.; Hill, K.; Zhou, Z. H.

10.1101/2025.05.29.656921 — microbiology — Posted on 2025-05-30

250 A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Tsujino, S.; Tsuda, M.; Ito, J.; Deguchi, S.; Taha, T. Y.; Nasser, H.; Wang, L.; Rosecrans, J.; Suzuki, R.; Suzuki, S.; Yoshimatsu, K.; Ott, M.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Ikeda, T.; Takayama, K.; Sato, K.; Tanaka, S.; Tamura, T.; Fukuhara, T.

10.1101/2025.05.28.656516 — microbiology — Posted on 2025-05-30

251 Tracing SARS-CoV-2 Evolution in Algeria: Insights from 2020-2023

Ezahedi, F. E.; Derrar, F.; Abraham, A.; Zeghbib, S.

10.1101/2025.05.28.656620 — molecular biology — Posted on 2025-05-30

252 Automated SP3 Workflow Enables Robust Sample Preparation on Proteonano Ultraplex Proteomics Platform

Wang, Y.; Wang, L.; Zhang, Y.; Ouyang, X.; Wu, H.

10.1101/2025.05.27.656469 — molecular biology — Posted on 2025-05-30

253 Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

Gazquez-Gutierrez, A.; Chin, P.; Peris, G.; Gordon, K.; Marchante, P. G.; Witteveldt, J.; Tristan-Ramos, P.; Rouviere, J. O.; Knol, L.; Ivens, A.; Lopez-Onieva, L.; Estevez, A. M.; Garland, W.; Jensen, T. H.; Heras, S. R.; Macias, S.

10.1101/2025.05.28.656609 — molecular biology — Posted on 2025-05-30

254 Transcriptomic perspective on acromegaly-related PIT-1/SF-1 positive pituitary tumors

Rymuza, J.; Zhang, Q.; Bujko, M.

10.1101/2025.05.28.656330 — molecular biology — Posted on 2025-05-30

255 Co-transcriptional folding orchestrates sequential multi-effector sensing by a glycine tandem riboswitch

Romero, R. A.; Chauvier, A. G.; Teh, S. S.; Reed, V. A.; Zhang, S.; Szyjka, C. E.; Chen, S.-J.; Strobel, E. J.; Walter, N. G.

10.1101/2025.05.28.656632 — molecular biology — Posted on 2025-05-30

256 CTCF-binding sites demarcate chromatin domains enriched with H3K9me2 or H3K9me3 and restrict the spreading of these histone modifications in human cells

Shin, K.-J.; Kang, J.; Kim, A.

10.1101/2025.05.28.656735 — molecular biology — Posted on 2025-05-30

257 Gag ubiquitination facilitates ALIX-mediated lentiviral RNA packaging, counteracted by USP8

Hagiuda, K.; Himi, Y.; Komada, M.; Fukushima, T.

10.1101/2025.05.27.656518 — molecular biology — Posted on 2025-05-30

258 Proteomics of Transglutaminase 2 polyaminated proteins

Hall, M. N.; Benjamin, D.; Ritz, D.; Park, S.; Shetty, S.

10.1101/2025.05.28.656543 — molecular biology — Posted on 2025-05-30

259 Dysfunction of a SET3-like complex underlies a family of related neurological disorders

Paton, K. M.; Alexander-Howden, B.; Hare, J. I.; Guy, J.; Chhatbar, K.; Yudina, M.; Walls, R.; Mathieson, T.; Spanos, C.; Bird, A. P.; Lyst, M. J.

10.1101/2025.05.30.657039 — molecular biology — Posted on 2025-05-30

260 The Elg1 Replication Factor C-like complex safeguards cells from replication stress through a noncanonical pathway independent of the Mec1-Rad53 axis

Bose, P.; Sau, S.

10.1101/2025.05.29.656775 — molecular biology — Posted on 2025-05-30

261 ClaPNAC: a Classifier of Protein - Nucleic Acid Contacts

Nikolaev, G.; Baulin, E. F.; Bujnicki, J. M.

10.1101/2025.05.30.657037 — molecular biology — Posted on 2025-05-30

262 RNA-seq of seven non-neoplastic/inflammatory lymphadenitis entities identify potential molecular diagnostic markers

Wang, J.; Lockhart, B.; Xu, J.; Pillai, V.

10.1101/2025.05.29.655793 — molecular biology — Posted on 2025-05-30

263 Chlamydia trachomatis restricts signaling through NOD2 until late in the pathogen's developmental cycle

Overman, G.; Loeckener, I.; Williford, Z.; Davis, S.; Diallo, A.; Henrichfreise, B.; Liechti, G. W.

10.1101/2025.05.28.656691 — microbiology — Posted on 2025-05-30

264 Context-dependent evolutionary dynamics toward bacterial survival during sequential antibiotic treatment

Lyon, A.; Yildiz, M. S.; Cooke, S.; Rosenthal, A.; Toprak, E.

10.1101/2025.04.08.647880 — microbiology — Posted on 2025-05-30

265 Microbiota comparison of individual and pooled cow fecal samples from PEI dairy farms

Sanchez, J.

10.1101/2025.05.29.656927 — microbiology — Posted on 2025-05-30

266 Whole genome analysis identified a cefotaxime-resistant Empedobacter brevis GBW-1 isolate from ground beef encoding a novel metallo-beta-lactamase variant, blaEBR-6

Jones, D.; Aggarwal, P.; Trewyn, J.; Shanmugam, P.; Leistikow, K. R.; Skwor, T. A.

10.1101/2025.05.30.656955 — microbiology — Posted on 2025-05-30

267 Intrinsic Repair Capacity of Resident Tendon Cells is Dependent on Hole Size in an Ex Vivo Model of Laser-Induced Microdamage

Aggouras, A. N.; Lim, M. T.; Eyckmans, J.; Connizzo, B. K.

10.1101/2025.05.29.656650 — bioengineering — Posted on 2025-05-30

268 CRISPR-Cas9 repair complexity in Drosophila melanogaster: NHEJ-induced deletions and HDR variability in the bantam microRNA gene

De Sousa, P.; Houbron, E.; Seitz, H.; Busseau, I.

10.1101/2025.05.29.656857 — genetics — Posted on 2025-05-30

269 Mitotic phosphorylation of ADAR1 regulates its centromeric localization and is required for faithful mitotic progression

Yang, Y.; Kubota, M.; Hasegawa, K.; Zeng, C.; Nishikura, K.; Hamada, M.; Sakurai, M.

10.1101/2025.05.28.656747 — molecular biology — Posted on 2025-05-30

270 Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene Smarcc2 and its Rescue by Histone Deacetylase Inhibition

Li, P.; Men, S.; Patel, P. J.; Zhong, P.; Yan, Z.

10.1101/2025.05.29.656867 — neuroscience — Posted on 2025-05-30

271 Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia

Sharkey, C.; Gu, B.; Long, X.; Tang, Y.; Patsatzis, N.; Li, S.; Olumi, A. F.; wang, z.

10.1101/2025.05.22.655540 — pathology — Posted on 2025-05-30

272 Assessment of Protein Complex Predictions in CASP16: Are we making progress?

Zhang, J.; Yuan, R.; Kryshtafovych, A.; Kretsch, R. C.; Schaeffer, R. D.; Zhou, J.; Das, R.; Grishin, N. V.; Cong, Q.

10.1101/2025.05.29.656875 — biophysics — Posted on 2025-05-30

273 SIREN: Suite for Intelligent RNAi Design and Evaluation of Nucleotide Sequences

Vargas Mejia, P.; Vega-Arreguin, J. C.

10.1101/2025.05.26.656188 — bioinformatics — Posted on 2025-05-30

274 MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos

Carey, C. M.; Parvez, S.; Brandt, Z. J.; Bisgrove, B. W.; Yates, C. J.; Peterson, R. T.; Gagnon, J. A.

10.1101/2025.05.27.656468 — genomics — Posted on 2025-05-30

275 Long-term citizen science data reveals environmental correlates of tropical tree flowering at the regional scale

Anujan, K.; Mardian, J.; Luo, C.; Rajkumar, R.; SeasonWatch Citizen Scientist Network, ; Tasic, H.; Akseer, N.; Ramaswami, G.

10.1101/2023.03.24.533907 — ecology — Posted on 2025-05-30

276 Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria

Nepal, Y.; Francian, A.; Flores-Garcia, Y.; Roberts, B. T.; David, S. A.; Zavala, F.; Chackerian, B.

10.1101/2025.03.03.641239 — immunology — Posted on 2025-05-30

277 Control of Inflammatory Response by Tissue Microenvironment

Wu, Z.; Pope, S. D.; Ahmed, N. S.; Leung, D. L.; Hajjar, S.; Yue, Q.; Anand, D. M.; Kopp, E. B.; Okin, D.; Ma, W.; Kagan, J. C.; Hargreaves, D. C.; Medzhitov, R.; Zhou, X.

10.1101/2024.05.10.592432 — immunology — Posted on 2025-05-30

278 Subcortically generated movements activate motor cortex during sleep and wake in rats through postnatal day 24

Reid, M. R.; Sattler, N. J.; Dooley, J. C.

10.1101/2025.01.26.634890 — neuroscience — Posted on 2025-05-30

279 Multi-omics Analysis Reveals Important Role for Microbial-derived Metabolites from Botryllus schlosseri in Metal Interactions

Matus, D. G. G.; Donaghy, C. M.; Vijayan, N.; Lane, Z. T.; Howell, M.; Glavin, G. G.; Angeles-Boza, A. M.; Nyholm, S. V.; Balunas, M. J.

10.1101/2024.11.10.622856 — systems biology — Posted on 2025-05-30

280 Combining model-based and data-driven models: an application to synthetic biology resource competition

Darabi, A.; An, Z.; Al-Radhawi, M. A.; Cho, W.; Siami, M.; Sontag, E.

10.1101/2025.03.09.642275 — systems biology — Posted on 2025-05-30

281 Effectiveness of a network Open House model to recruit trainees to post-baccalaureate STEM programs

Aoki, S. T.; Lewellyn, L.; Justice, S.; Mordan-McCombs, S.; Tewari, N.; Cantu, J.; Seiser, R.; Lakhani, A.; Kowalski, J. R.

10.1101/2024.01.08.574670 — scientific communication and education — Posted on 2025-05-30

282 Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium Channels

Chan, A. N.; Quach, C. D.; Handlin, L. J.; Lessie, E. N.; Tajkhorshid, E.; Dai, G.

10.1101/2024.05.17.594747 — biophysics — Posted on 2025-05-30

283 Hatching with Numbers: Pre-natal Light Exposure Affects Number Sense and the Mental Number Line in young domestic chicks

Rugani, R.; Macchinizzi, M.; Zhang, Y.; Regolin, L.

10.1101/2025.03.09.642211 — animal behavior and cognition — Posted on 2025-05-30

284 Functional characterization of the disease-associated CCL2 rs1024611G-rs13900T haplotype: The role of the RNA-binding protein HuR

Akhtar, F.; Ruiz, J. H.; Liu, Y.-G.; Resendez, R. G.; Feliers, D.; Morales, L. D.; Diaz-Badillo, A.; Lehman, D. M.; Arya, R.; Alvarenga, J. C. L.; Blangero, J.; Duggirala, R.; Mummidi, S.

10.1101/2023.10.31.564937 — genomics — Posted on 2025-05-30

285 Not all alloantibodies are created equal: IgG glycosylation and severity of antibody-mediated rejection in kidney transplantation

Noble, J.; Glendenning, L. M.; Dard, C.; Bourdin, A.; Carlson, G. C.; Cobb, B. A.; Cravedi, P.

10.1101/2025.05.28.656600 — immunology — Posted on 2025-05-30

286 Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL2

Gwynne, M.; West, K. A.; van Dongen, S.; Kourtzelis, I.; Coverley, D.; Teichmann, S. A.; James, K. R.; Hewitson, J. P.; Lagos, D.

10.1101/2024.10.23.619648 — immunology — Posted on 2025-05-30

287 Movement-related activity in the internal globus pallidus of the parkinsonian macaque

Kase, D.; Zimnik, A. J.; Han, Y.; Harsch, D. R.; Bacha, S.; Cox, K. M.; Bostan, A. C.; Richardson, R. M.; Turner, R. S.

10.1101/2024.08.29.610310 — neuroscience — Posted on 2025-05-30

288 Neural connectivity of a computational map for fly flight control.

Dhawan, S.; Huang, Z.; Dickerson, B. H.

10.1101/2025.05.29.656834 — neuroscience — Posted on 2025-05-30

289 Entropy tree networks of residue dynamics encode protein allostery

Trenfield, K.; Lin, M. M.

10.1101/2025.05.28.656549 — biophysics — Posted on 2025-05-30

290 Conformational Dynamics of the Nuclear Pore Complex: Insights from Elastic Network Models and Coarse-Grained Simulations

Wang, H.; Chen, G.; Zhang, Z.

10.1101/2025.05.28.656622 — biophysics — Posted on 2025-05-30

291 Interactions Between Hantavirus Nucleoprotein and Glycoproteins: a quantitative fluorescence microscopy study

Aji, A. K.; Chiantia, S.

10.1101/2025.05.28.656537 — biophysics — Posted on 2025-05-30

292 Active Gaussian Network Model: a non-equilibrium description of protein fluctuations and allosteric behavior

Costantini, G.; Caprini, L.; Marini Bettolo Marconi, U.; Cecconi, F.

10.1101/2025.05.28.656626 — biophysics — Posted on 2025-05-30

293 The Arch from the Stones: Understanding Protein Folding Energy Landscapes via Bio-inspired Collective Variables

Rizzi, V.; Heritier, M.; Piasentin, N.; Aureli, S.; Gervasio, F. L.

10.1101/2025.05.28.656575 — biophysics — Posted on 2025-05-30

294 Mechanical Responses of the Giant Nesprin-2

Shang, F.; Zhang, Y.; Ye, J.; Zhang, Z.; Qi, X.; Chen, H.; Yu, M.; Le, S.

10.1101/2025.05.30.657030 — biophysics — Posted on 2025-05-30

295 Lipid gating of BK channels and mechanism of activation by negatively charged lipids

Mironenko, A.; de Groot, B. L.; Kopec, W.

10.1101/2025.05.27.656279 — biophysics — Posted on 2025-05-30

296 Bridging Worlds: Connecting Glycan Representations with Glycoinformatics via Universal Input and a Canonicalized Nomenclature

Urban, J.; Joeres, R.; Bojar, D.

10.1101/2025.05.30.657013 — bioinformatics — Posted on 2025-05-30

297 Robust Deep Denoising of Soft X-Ray Tomography Data for Biological Research: Targeting Tilt Series Versus Reconstructed Tomograms

Chueh, S.; Simpson, J. C.; Kapishnikov, S.

10.1101/2025.05.16.654457 — bioengineering — Posted on 2025-05-30

298 PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures

Crouch, L. I.; Bakshani, C. R.; Urbanowicz, P.; Tortosa, C. B.; Diaz, J. M. M.; Kujawska, M.; Ojuri, T. O.; Hall, L. J.; Spencer, D. I.; Bolam, D. N.

10.1101/2025.05.27.656428 — biochemistry — Posted on 2025-05-30

299 Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines

Cinar, M. S.; Adams, T. M.; Ozdilek, A.; Avci, F.

10.1101/2025.05.29.656815 — biochemistry — Posted on 2025-05-30

300 ECgo: All-Optical Induction of Single Endothelial Cell Injury and Capillary Occlusion in the Brain

Condrau, J.; Allu, S. R.; Esipova, T. V.; Erlebach, E.; Wyss, M. T.; Glueck, C.; Ravotto, L.; Troxler, T.; Villa, M.; Ceroni, P.; El Amki, M.; Vinogradov, S. A.; Weber, B.

10.1101/2025.05.27.656398 — neuroscience — Posted on 2025-05-30

301 A PDZ-RapGEF promotes synaptic development in C. elegans through a Rap/Rac signaling pathway

Lamb, R.; Scales, M.; Watkins, J.; Werner, M.; Cherra, S. J.

10.1101/2025.05.27.656318 — neuroscience — Posted on 2025-05-30

302 Lipidomic signatures in microglial extracellular vesicles during acute inflammation: a gateway to neurological biomarkers

Ollen-Bittle, N.; Wang, W.; Molina-Bean, K.; Zhao, S.; Buzatto, A. Z.; Dong, Y.; Li, L.; Whitehead, S. N.

10.1101/2025.05.27.656354 — neuroscience — Posted on 2025-05-30

303 Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin

Joseph, K.; Collins, J.; Genovese, T.; Maxwell, M.; Lieberman, J. A.; Osten, P.

10.1101/2025.05.26.655791 — neuroscience — Posted on 2025-05-30

304 Leveraging Dynamic Stability to Infer Regulation in Protein-Protein Interaction Networks: A Study of Infectious Vulnerability in COPD.

Reimer, J.; Page, J.; Saha, P.; Shen, S.; Zhu, X.; Qian, S.; Mammen, M.; Qu, J.; Sethi, S.; Broderick, G. J.

10.1101/2025.05.26.656208 — systems biology — Posted on 2025-05-30

305 Molecular Insights into CLD Domain Dynamics and Toxin Recruitment of the HlyA E. coli T1SS

Gentile, R.; Schott-Verdugo, S.; Khosa, S.; Bonus, M.; Reiners, J.; Smits, S.; Schmitt, L.; Gohlke, H.

10.1101/2025.05.27.656419 — biophysics — Posted on 2025-05-30

306 Robust Estimation of Rotational Diffusion Tensors of Proteins from Molecular Dynamics Simulations

Holtbrügge, S. L.; Schäfer, L. V.

10.1101/2025.05.27.656261 — biophysics — Posted on 2025-05-30

307 Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G-quadruplexes

Mustafa, G.; Shiekh, S. A.; Alfehaid, J.; Kodikara, S.; Balci, H.

10.1101/2025.05.26.656241 — biophysics — Posted on 2025-05-30

308 Gene Loss DB: A curated database for gene loss in vertebrate species.

Themudo, G. E.; Ruivo, R.; Valente, R.; Artilheiro, N.; Oliveira, D.; Amorim, I.; Pinto, B.; Castro, L. F. C.; Fernandes, S.; Lopes-Marques, M.

10.1101/2025.05.26.656173 — bioinformatics — Posted on 2025-05-30

309 L-selectin shedding regulates functional recovery and neutrophil clearance following spinal cord injury in a sex-dependent manner

Leal-Garcia, M. E.; Pacheco, M. R.; Reid, S. K.; Tseng, V. S.; Kirchhoff, M.; Tadiboyina, S.; Min, D.; McCreedy, D.

10.1101/2025.05.28.656699 — neuroscience — Posted on 2025-05-30

310 In vivo calcium imaging shows that dorsal root ganglion stimulation predominantly activates large-sized sensory neurons in mice

Goodwin, G. L.; Franken, G.

10.1101/2025.05.27.656338 — neuroscience — Posted on 2025-05-30

311 Crowdsourced Wildlife Observations Uncover Ecotourism Assets-Sites and Species

Atsumi, K.; Tsujino, T.; Nakaseko, M.; Ogasawara, S.; Tsuboi, R.; Taga, H.; Nishida, T.

10.1101/2025.05.26.656219 — ecology — Posted on 2025-05-30

312 Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents

Jia, Y. Y.; Bajsert, J.; Perez-Aso, M.; Atwood, S.

10.1101/2025.05.29.656859 — cell biology — Posted on 2025-05-30

313 Disentangling objects' contextual associations from perceptual and conceptual attributes using time-resolved neural decoding

Kim, A. H.; Quek, G. L.; Moerel, D. L.; Gorton, O. K.; Carlson, T. A.

10.1101/2025.05.29.656895 — neuroscience — Posted on 2025-05-30

314 Beyond the first glance: How human presence enhances visual entropy and promotes spatial learning

Sanchez Pacheco, T. L.; Nolte, D.; König, S. U.; Pipa, G.; König, P.

10.1101/2025.05.29.656764 — neuroscience — Posted on 2025-05-30

315 Neural integration of acoustic statistics enables detecting acoustic targets in noise

Alishbayli, A.; Przewrocki, K.; van Heumen, P.; Englitz, B.

10.1101/2025.05.29.656794 — neuroscience — Posted on 2025-05-30

316 The genetic architecture of quantitative variation in the self-incompatibility response within Phlox drummondii (Polemoniaceae)

Burgin, G. A.; Roda, F.; Farnitano, M.; Hale, C.; Serrato-Capuchina, A.; Hopkins, R.

10.1101/2025.05.27.656016 — plant biology — Posted on 2025-05-30

317 Transpiration, Photoinhibition and Non-photochemical Quenching Reciprocally Control Foliar Heat Emission

Zarrin Ghalami, R.; Duszyn, M.; Kamran, M.; Burdiak, P.; Gawronski, P.; Karpinski, S.

10.1101/2025.05.27.656286 — plant biology — Posted on 2025-05-30

318 A CRISPR/Cas9-induced restoration of bioluminescence reporter system for single-cell gene expression analysis in plants

Ueno, R.; Ito, S.; Oyama, T.

10.1101/2025.05.27.656507 — plant biology — Posted on 2025-05-30

319 Stage-resolved gene regulatory network analysis reveals developmental reprogramming and genes with robust stem-preferred expression in sorghum

Fu, J.; James, B.; Hetti-Arachchilage, M.; Lei, Y.; McKinley, B.; Kurtz, E.; Barry, K.; Moose, S. P.; Mullet, J. E.; Swaminathan, K.; Marshall-Colon, A.

10.1101/2025.05.27.656329 — plant biology — Posted on 2025-05-30

320 Microbial Modulation of Host Plant Proteasome Activity Improves Heat Stress Tolerance

Lee, J. H.; Carrell, A. A.; Piatkowski, B.; Carper, D. L.; Gunter, L.; Jawdy, S.; Carter, K.; Doktycz, M.; Abraham, P. E.; Schmutz, J.; Lovell, J. T.; Healey, A.; Pelletier, D. A.; Weston, D. J.

10.1101/2025.05.27.656411 — plant biology — Posted on 2025-05-30

321 A Transcriptomics-Based Computational Drug Repositioning Pipeline Identifies Simvastatin And Primaquine As Novel Therapeutics For Endometriosis Pain

Oskotsky, T. T.; Tang, X.; Arthurs, E.; Govil, A.; Abbasi, F.; Bhoja, A.; Bunis, D. J.; Lau, A.; Einhaus, J.; Diop, M.; Irwin, J. C.; Gaudilliere, B.; Stevenson, D. K.; Giudice, L. C.; McAllister, S. L.; Sirota, M.

10.1101/2025.05.28.656743 — bioinformatics — Posted on 2025-05-30

322 Fine-Resolution Asymmetric Migration Estimation

Shen, H.; Novembre, J.

10.1101/2025.05.29.656894 — genetics — Posted on 2025-05-30

323 An updated view of the vertebrate selenoproteome reveals convergent depletions in tetrapods and expansions in ray-finned fishes

Tico, M.; Mariotti, M.

10.1101/2025.05.29.656587 — evolutionary biology — Posted on 2025-05-30

324 Identification and removal of contamination in palaeoproteomic analysis of dental enamel

Fagernäs, Z.; Sieling, S.; Troche, G.; Bakker, J. K.; Olsen, J. V.; Welker, F.

10.1101/2025.05.30.657004 — evolutionary biology — Posted on 2025-05-30

325 Snail-trematode dynamics in central Alberta wetlands: A longitudinal survey of infections and interactions

McPhail, B. A.; Tomusiak, S.; Veinot, H.; Dodds, N.; Hanington, P. C.

10.1101/2025.05.26.656203 — ecology — Posted on 2025-05-30

326 Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration

Dockery, R.; Zevallos, M.; McNulty, C.; Zecchino, T.; Ratermann, R.; Goldman, J. A.

10.1101/2025.05.27.656424 — developmental biology — Posted on 2025-05-30

327 Integrin-binding matricellular protein fibulin-5 maintains epidermal stem cell heterogeneity during skin aging

Fan, W.; Ishikawa, M.; Raja, E.; Hegazy, A. M.; Date, H.; Ngo, Y. X.; Sato, Y.; Yamagata, K.; Yanagisawa, H.; Sada, A.

10.1101/2025.05.26.656217 — developmental biology — Posted on 2025-05-30

328 Start Small: A Model for Tissue-wide Planar Cell Polarity without Morphogens

Thayambath, A.; Belmonte, J. M.

10.1101/2025.05.26.655839 — developmental biology — Posted on 2025-05-30

329 Helical Growth of Twining Common Bean is Associated with Longitudinal, Not Skewed, Microtubule Patterning

Acevedo, A. A.; Sousa-Baena, M. S.; Onyenedum, J. G.

10.1101/2025.05.27.656463 — developmental biology — Posted on 2025-05-30

330 Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.

van der Veer, B. K.; Custers, C.; Brangers, W.; Cornelis, R.; Champeris Tsaniras, S.; De Ridder, K.; Thienpont, B.; Cheng, H.; Chen, Q.; Kraushaar, D.; Finnell, R. H.; Gross, S.; Koh, K. P.

10.1101/2025.05.27.656260 — developmental biology — Posted on 2025-05-30

331 Multiplexed proximity labelling proteomics identifies a non-canonical Bcl-2 family interactome associated with apoptotic priming

Pedley, R.; Mellor, C.; King, L.; Jones, M.; Taylor-Hearn, I.; Mironov, A.; Lawless, C.; Gilmore, A. P.

10.1101/2025.05.30.657000 — cell biology — Posted on 2025-05-30

332 Impacts of stress and aging on spore health in Schizosaccharomyces pombe

Nuckolls, N. L.; Eickbush, M. T.; Lange, J. J.; Wood, C. J.; Nowotarski, S. H.; Zanders, S. E.

10.1101/2025.05.29.656811 — cell biology — Posted on 2025-05-30

333 An intermediate activation state primes Langerhans cell migration from the epidermis

Kiselev, A.; Schmitter-Sanchez, A. D.; Williams, S.; Park, S.

10.1101/2025.05.29.656912 — cell biology — Posted on 2025-05-30

334 Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart

Crossman, D. J.; Guo, G.; Shanks, J.; Pachen, M.; Bai, J.; Moammer, H.; Middleditch, M. J.; Grey, G.; Paton, J. F.; Ramchandra, R.

10.1101/2025.05.29.656916 — cell biology — Posted on 2025-05-30

335 Human Serum Albumin as a Hidden Source of Variability in IVF Culture Media

Nezvedova, M.; Porokh, V.; Bockova, T.; Pustka, V.; Kyjovska, D.; Maierova, B.; Kloudova, S.; Otevrel, P.; Holubcova, Z.

10.1101/2025.05.29.656106 — cell biology — Posted on 2025-05-30

336 Glucose Starvation Sensing through Membrane Remodeling at theNucleus-Vacuole Junction Coordinates Ergosterol Biosynthesis

Fujimoto, S.; Tamura, Y.

10.1101/2025.05.29.656913 — cell biology — Posted on 2025-05-30

337 Role of Pex31 in metabolic adaptation of the nucleus vacuole junction NVJ

Hugenroth, M.; Höhne, P.; Zhao, X.-T.; Wälte, M.; Diep, D. T. V.; Fausten, R. M.; Bohnert, M.

10.1101/2025.05.29.656872 — cell biology — Posted on 2025-05-30

338 Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

Mayer, A.; Bru, S.; Michaillat Mayer, L.; Kim, G.-D.; Jessen, H.; Qiu, D.

10.1101/2025.05.30.656997 — cell biology — Posted on 2025-05-30

339 Effects of sexual dimorphism and estrous cycle on C. difficile infections prophylaxis in two rodent models

Phan, J. R.; Washington, M.; Do, D. M.; Mata, T. V.; Niamba, M.; Heredia, E.; Soriano, R.; Hassan, C.; Cross, C. L.; Abel-Santos, E.

10.1101/2025.05.21.655361 — microbiology — Posted on 2025-05-30

340 Tensor-Based Integration of Time-Series Measurements Reveals Relationships Between Underlying Disease, Early Injury, and CD4+ Polarization in Liver Transplantation

Chin, J. L.; Tan, Z. C.; Sosa, R. A.; Zheng, Y.; Gjertson, D. W.; Hoffman, A.; Kaldas, F. M.; Zhai, Y.; Kupiec-Weglinski, J. W.; Reed, E. F.; Meyer, A. S.

10.1101/2025.05.29.655766 — immunology — Posted on 2025-05-30

341 Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

Medina-Serpas, M. A.; Brusko, M.; Golden, G. J.; Campbell-Thompson, M.; Rogers, T.; Posgai, A. L.; Luning-Prak, E. T.; Liu, C.; Kaestner, K. H.; Naji, A.; Betts, M. R.; McIntyre, L. M.; Atkinson, M. A.; Brusko, T. M.

10.1101/2025.05.19.654940 — immunology — Posted on 2025-05-30

342 FAM83H regulates postnatal T cell development through thymic stroma organization

Ogan, B. M.; Forstlova, V.; Dowling, L. J.; Simova, M.; Vicikova, K.; Novosadova, V.; Spoutil, F.; Cervenkova, S.; Prochazkova, M.; Tureckova, J.; Fedosieieva, O.; Labaj, J.; Nickl, P.; Krizova, K.; Prochazka, J.; Sedlacek, R.; Balounova, J.

10.1101/2025.05.26.656197 — immunology — Posted on 2025-05-30

343 Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion

Boen, R.; Villalon-Reina, J. E.; Kushan, L.; O'Hora, K. P.; Fung, H.; Parker, N.; Akkouh, I. A.; Alnaes, D.; O'Hara, R.; Marzelli, M. J.; Foland-Ross, L.; Chick, C. F.; Cotto, I.; Reiss, A. L.; Hallmayer, J.; Thompson, P. M.; Andreassen, O. A.; Sonderby, I. E.; Bearden, C. E.

10.1101/2025.05.29.656839 — neuroscience — Posted on 2025-05-30

344 An increased excitation and inhibition onto CA1 pyramidal cells sets the path to Alzheimer s disease

Scimemi, A.; Wehrle, P.; Rathwell, T.; Petroccione, M.; Caiazza, E.; Manning, A.; Frasson dos Reis, L.; Todd, G.; Affinnih, N.; Ahmad, S.; Mehdi, H.; Tschang, I.; Hassan, U.; Tsakh, B.; Darvas, M.; Cook, D.

10.1101/2025.05.27.656417 — neuroscience — Posted on 2025-05-30

345 Enhancing Secondary School Students' Attitudes towards Biology through Guided Inquiry-Based Lab Instructions

Chengere, A. M.; Dobo, B. B.; Zinabu, S. A.; Jilo, K. W.

10.1101/2025.05.29.656923 — scientific communication and education — Posted on 2025-05-30

346 COmapper: High-resolution mapping of meiotic crossovers by long-read sequencing in Arabidopsis

Byun, D.; Son, N.; Kim, H.; Kim, J.; Park, J.; Park, S.-j.; Kim, H.; Kim, J.; Kim, J.; Lee, S.; Hyun, Y.; Ziolkowski, P. A.; Henderson, I. R.; Choi, K.

10.1101/2024.10.21.619347 — plant biology — Posted on 2025-05-30

347 Dynamic changes to the plastoglobule lipidome and proteome in water-deficient maize

Devadasu, E.; Schilmiller, A. L.; Gonzalez, N.; Lundquist, P. K.

10.1101/2025.05.26.656201 — plant biology — Posted on 2025-05-30

348 The signature of reproduction on wood anatomy in European beech reveals potential for masting reconstruction

Resente, G.; Crivellaro, A.; Fleurot, E.; Piermattei, A.; Maimone, F.; Wilmking, M.; Hacket-Pain, A.; Motta, R.; Ascoli, D.

10.1101/2025.05.27.656364 — plant biology — Posted on 2025-05-30

349 Optimization of a Cannabis sativa micropropagation protocol (chemotype III) to preserve its cannabinoid profile

Gonzalez, M.; Yaniuk, G.; Sannazzaro, A.; Butassi, E.; Di Liberto, M.; Perez, E.; Hourcade, M.; Svetaz, L.; Clemente, M.

10.1101/2025.05.26.656187 — plant biology — Posted on 2025-05-30

350 Using Fiji as a simplified tool for assessing alveolar chord length and septal thickness in neonatal pulmonary disease research

Das, P.; Martini, E.; Aloudat, O.; Tran, E.; Rajendran, D. T.; Agarwal, B.; Homer, R. J.; Bhandari, V.

10.1101/2025.05.29.656796 — pathology — Posted on 2025-05-30

351 Benchmarking Universal Machine Learning Force Fields with Hydrogen-Bonding Cooperativity

Feng, X.; Xu, Y.; Huang, J.

10.1101/2025.04.29.651212 — biophysics — Posted on 2025-05-30

352 Kinetic Insights into Photoinduced Monomer-Dimer Conversion and Activation of Orange Carotenoid Protein

Tokashiki, T.; Ohata, T.; Tokonami, S.; Nakaosne, Y.; Terazima, M.

10.1101/2025.05.26.656073 — biophysics — Posted on 2025-05-30

353 Mechanistic basis for the opposing effects of H2A and H2B ubiquitination on nucleosome stability and dynamics

Baweja, L.; Wereszczynski, J.

10.1101/2025.02.13.638112 — biophysics — Posted on 2025-05-30

354 Quantifying the shape of cells - from Minkowski tensors to p-atic order

Happel, L.; Griseldis, O.; Grudtsyna, V.; Jain, H. P.; Sknepnek, R.; Doostmohammadi, A.; Voigt, A.

10.1101/2025.01.03.631196 — biophysics — Posted on 2025-05-30

355 Genetic-to-chemical perturbation transfer learning through unified multimodal molecular representations

Li, Y.; Zeng, M.; Zhu, J.; Liu, L.; Wang, F.; Huang, L.; Yang, F.; Li, M.; Yao, J.

10.1101/2025.02.02.635055 — bioinformatics — Posted on 2025-05-30

356 omicsGMF: a multi-tool for dimensionality reduction, batch correction and imputation applied to bulk- and single cell proteomics data.

Segers, A.; Castiglione, C.; Vanderaa, C.; Martens, L.; Risso, D.; Clement, L.

10.1101/2025.03.24.644996 — bioinformatics — Posted on 2025-05-30

357 GeneWhisperer: Enhancing manual genome annotation with large language models

Li, X.; Whan, A. P.; McNeil, M.; Andrew, S. C.; Dai, X.; Fechner, M.; Paris, C.; Suchecki, R.

10.1101/2025.03.30.646211 — bioinformatics — Posted on 2025-05-30

358 Integrating process, proximity, and prediction implicates novel protein and RNA interactions in human Origin Recognition Complex function

Smolka, J. A.

10.1101/2025.05.28.651956 — bioinformatics — Posted on 2025-05-30

359 Polyimide-Based Flexible Multi-Electrode Arrays for Epilepsy: Synthesis, Microfabrication, and In-Vivo Validation In A Rodent Model of Epilepsy

Kumar, K.; Deshpande, K.; Kalur, N.; Chauhan, G.; Chugh, D.; Ganesh, S.; Ramakrishnan, A.

10.1101/2023.09.12.557325 — bioengineering — Posted on 2025-05-30

360 obABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors

Jones, H. B. L.; Draganov, S. D.; Schonbauer Huaman, S.; Wing, P. A.; Nguyen, C.; Liang, Z.; Dorner, J.; Lithgow, J.; Murphy, E.; Beard, A.; Pierangelini, A.; Houghton, J. W.; Robert, M. E.; Flannery, S.; Tumber, A.; Vendrell, I.; Tate, E. W.; Elliott, P. R.; West, G. M.; O'Brien, D. P.; Salah, E.; Turnbull, A. P.; Schofield, C. J.; Kessler, B. M.; Brewitz, L.; Pinto-Fernandez, A.

10.1101/2025.05.27.656269 — biochemistry — Posted on 2025-05-30

361 Megabouts: a flexible pipeline for zebrafish locomotion analysis

Jouary, A.; Silva, P. T. M.; Laborde, A.; Mata, J. M.; Marques, J. C.; Collins, E.; Peterson, R. T.; Machens, C. K.; Orger, M. B.

10.1101/2024.09.14.613078 — animal behavior and cognition — Posted on 2025-05-30

362 Clade-wide fungal proteome analysis reveals structure-function conservation in divergent Dicer proteins

Melet, L.; Canan, J.; Villalobos, P.; Vidal-Veuthey, B.; Gonzalez-Toro, F.; Orellana, I.; Rivas-Pardo, J. A.; Cardenas, J. P.; Moraga, C.; Castro-Fernandez, V.; Johnson, N. R.; Vidal, E. A.

10.1101/2025.04.28.651110 — genomics — Posted on 2025-05-30

363 Principles and functional consequences of plasmid chromatinization in mammalian cells

Mallory, B. J.; Tullius, T. W.; Biar, C. G.; Gustafson, J. A.; Bohaczuk, S. C.; Dubocanin, D.; Starita, L. M.; Stergachis, A. B.

10.1101/2025.05.27.656122 — genomics — Posted on 2025-05-30

364 The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice.

Kageyama, A.; Ogonuki, N.; Wakai, T.; Namiki, T.; Kawata, Y.; Ozawa, M.; Yamada, Y.; Fukada, T.; Ogura, A.; Fissore, R. A.; Kashiwazaki, N.; Ito, J.

10.1101/2024.09.11.612381 — developmental biology — Posted on 2025-05-30

365 Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

Wang, D.; Wang, H.; Wan, W.; Zhu, Z.; Sho, T.; Zheng, Y.; Zhang, X.; Dou, L.; Ding, Q.; Yu, L.; Liu, Z.

10.1101/2024.03.13.584850 — cell biology — Posted on 2025-05-30

366 Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins

Luthold, C.; Didion, M.; Benedum, E.; Burkhart, A.-K.; Demmerle, N.; Wirth, E.; Gunaratnam, G.; Racz, V. S.; Thangamurugan, S.; Helms, V.; Bischoff, M.; Ridzal, A.; Iden, S.

10.1101/2024.10.04.616635 — cell biology — Posted on 2025-05-30

367 Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks

Gilep, K.; Obarska-Kosinska, A.; Kosinski, J.

10.1101/2024.12.03.626671 — molecular biology — Posted on 2025-05-30

368 Development and optimisation of Influenza C and Influenza D pseudotyped viruses

Marotta, M. G.; Neto, M. M.; Daly, J. M.; Maina, M.; van Diemen, P.; Everett, H.; Lucente, M. S.; Camero, M.; Montomoli, E.; Trombetta, C. M.; da Costa, K.; Temperton, N.

10.1101/2025.05.26.656172 — immunology — Posted on 2025-05-30

369 CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence

Heim, T. A.; Ibrahim, O.; Lin, Z.; Steele, M. M.; Mudianto, T.; Lund, A. W.

10.1101/2023.02.14.528487 — immunology — Posted on 2025-05-30

370 Perceptual prediction error supports implicit process in motor learning.

Zhang, X.; Wu, W.; Wei, K.

10.1101/2025.04.29.651214 — neuroscience — Posted on 2025-05-30

371 Population coding under the scale-invariance of high-dimensional noise

Moosavi, S. A.; Hindupur, S. S. R.; Shimazaki, H.

10.1101/2024.08.23.608710 — neuroscience — Posted on 2025-05-30

372 Kernel Filter-Based Adaptive Controllers For Cybergenetics Applications

Smart, B. C.; Marucci, L.; Renson, L.

10.1101/2024.10.21.619394 — systems biology — Posted on 2025-05-30

373 Ultrasound-Driven Programmable Artificial Muscles

Shi, Z.; Zhang, Z.; Schnermann, J.; Neuhauss, S. C. F.; Nama, N.; Wittkowski, R.; Ahmed, D.

10.1101/2024.01.08.574699 — bioengineering — Posted on 2025-05-30

374 A forest is more than its trees: haplotypes and inferred ARGs

Fritze, H.; Pope, N.; Kelleher, J.; Ralph, P. L.

10.1101/2024.11.30.626138 — genomics — Posted on 2025-05-30

375 White and Brown Adipose Tissue Share a Common Fibro-Adipogenic Progenitor Population

Galmozzi, A.; Bui, H.; Hansen, J. K.; Lo Sardo, V.

10.1101/2025.05.28.656577 — physiology — Posted on 2025-05-30

376 Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene Smarcc2 and its Rescue by Histone Deacetylase Inhibition

Li, P.; Men, S.; Patel, P. J.; Zhong, P.; Yan, Z.

10.1101/2025.05.29.656867 — neuroscience — Posted on 2025-05-30

377 Heightened Sensitivity to Voice Loudness Changes in Parkinson's Disease

Contreras Ruston, F.; Criscuolo, A.; Callen, A.; Cucurell, D.; Navarra, J.; Kotz, S. A.

10.1101/2025.05.29.656769 — neuroscience — Posted on 2025-05-30

378 A Multi-Region Brain Model to Elucidate the Role of Hippocampus in Spatially Embedded Decision-Making

Xie, Y.; Hwang, J.; Brody, C.; Tank, D. W.; Fiete, I.

10.1101/2025.05.29.656671 — neuroscience — Posted on 2025-05-30

379 Resolving the full set of human polymorphic inversions and other complex variants from ultra-long read data

Moreira-Pinhal, R.; Karakostis, K.; Yakymenko, I.; Conchillo, O.; Diaz-Ros, M.; Santos, A.; Senar, M. A.; Martinez-Urtaza, J.; Puig, M.; Caceres, M.

10.1101/2025.05.27.656315 — genomics — Posted on 2025-05-29

380 STARD3 coordinates Endoplasmic Reticulum-late endosome/lysosome contacts and organelle positioning through a GSK3-regulated phosphorylation switch

Eichler, J.; Wendling, C.; Huver, S.; Zouiouich, M.; Hanss, V.; Cardinal, A.; Fimbel, V.; Birck, C.; McEwen, A. G.; Knorr, C.; Fromental-Ramain, C.; Boutry, M.; Chenard, M.-P.; DRIN, G.; Tomasetto, C.; ALPY, F.

10.1101/2025.05.29.656564 — cell biology — Posted on 2025-05-30

381 Ammonia-mediated Conformational Dynamics in SCAP for SREBP Activation

Chan, C.; Li, Z.; Yang, Y.; Guo, D.; Cheng, X.

10.1101/2025.05.29.656818 — molecular biology — Posted on 2025-05-29

382 Multifaceted brain representation of numerosity across the senses and presentation formats

Yang, Y.; Fornaciai, M.; Togoli, I.; Shahzad, I.; Gau, R.; Van Audenhaege, A.; Cerpelloni, F.; Collignon, O.

10.1101/2025.05.29.653470 — neuroscience — Posted on 2025-05-29

383 Neural connectivity of a computational map for fly flight control.

Dhawan, S.; Huang, Z.; Dickerson, B. H.

10.1101/2025.05.29.656834 — neuroscience — Posted on 2025-05-29

384 Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex

Bolshakova, S.; Carmen Sifuentes, S. E.; Phadke, R. A.; Brack, A.; Caley, P.; Dias, C.; Cruz Martin, A.

10.1101/2025.05.29.656749 — neuroscience — Posted on 2025-05-29

385 Cholinergic disruption of state-dependent retrosplenial layer 1 activity causes temporal associative memory deficit under stress

Tanimura, A.; Login, H.; Feld-Jakobsen, S. O.; Hou, W.-H.; Gunnink, H.; Nakamoto-Griffiths, C.; Overmark, T.; Radulovic, J.; Yamawaki, N.

10.1101/2025.05.27.656297 — neuroscience — Posted on 2025-05-29

386 Prolonged Single Neuron Voltage Imaging in Behaving Mammals

Wang, Y.; Ravasio, C. R.; Zhou, Y.; Han, X.

10.1101/2025.05.29.656886 — neuroscience — Posted on 2025-05-30

387 Neural integration of acoustic statistics enables detecting acoustic targets in noise

Englitz, B.; Alishbayli, A.; Przewrocki, K.; van Heumen, P.

10.1101/2025.05.29.656794 — neuroscience — Posted on 2025-05-30

388 Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome

Almassalha, L. M.; MacQuarrie, K.; Carignano, M.; Dunton, C.; Gong, R.; Ibarra, J.; Carter, L.; Li, W. S.; Nap, R.; Dulai, P. S.; Szleifer, I.; Backman, V. m.

10.1101/2025.05.29.656862 — biophysics — Posted on 2025-05-29

389 The development of trait anxiety in nonhuman primates during the first year of life

Puralewski, R. F.; Aggarwal, N.; Oler, J.; Roseboom, P. H.; Parkins, L.; Riedel, M. K.; Boettcher, C.; Kalin, N. H.

10.1101/2025.05.29.654506 — animal behavior and cognition — Posted on 2025-05-29

390 Modulation of Filopodial Myosin Function

Crawford, A.; Schwartz, J. K.; Hall, E.; Houdusse, A.; Titus, M. A.

10.1101/2025.05.29.656896 — cell biology — Posted on 2025-05-29

391 Understanding the Role of Pyruvate Dehydrogenase in Listeria monocytogenes Virulence

Freeman, M. J.; Eral, N. J.; Debrine, A. M.; Stevenson, D. M.; Amador-Noguez, D.; Sauer, J.-D.

10.1101/2025.05.29.656449 — microbiology — Posted on 2025-05-29

392 The ATO gene family governs Candida albicans colonisation in the dysbiotic gastrointestinal tract

Alves, R.; Ghasemi, F.; Van Genecthen, W.; Wijnants, S.; Van Goethem, O.; Barata-Antunes, C.; Fernandes, V.; Ataide, P.; Gomes-Goncalves, A.; Vergauwen, R.; Ma, Q.; Duarte, R.; Soares-Silva, I.; Casal, M.; Brown, A. J.; Van Dijck, P.; Paiva, S.

10.1101/2025.05.29.656788 — microbiology — Posted on 2025-05-29

393 Decoding ultrasensitive self-assembly of the calcium-regulated Tetrahymena cytoskeletal protein Tcb2 using optical actuation.

Chandrasekharan, N. P.; Lei, X.; Honts, J. H.; Bhamla, S.; Coyle, S. M.

10.1101/2025.05.26.656216 — biophysics — Posted on 2025-05-29

394 Synthesis of C8-vinyl chlorophylls d and f impairs far-red light photoacclimation and growth under far-red light

Chaudhary, A. K.; Fuchs, L. K.; Pawlak, K.; Dykes, G. F.; Goodacre, R.; Nürnberg, D. J.; Canniffe, D. P.

10.1101/2025.05.26.656186 — biochemistry — Posted on 2025-05-29

395 Kre6-Dependent β-1,6-glucan Biosynthesis Only Occurs in the Conidium of Aspergillus fumigatus

Singh, K.; Henry, C.; Beauvais, A.; Xu, Y.; Mouyna, I.; Latge, J.-P.; Wang, T.

10.1101/2025.05.29.656687 — biochemistry — Posted on 2025-05-29

396 Tirzepatide reduces diet-induced senescence and NETosis-mediated liver fibrosis in mice

Chen, F.; Nam, Q.; Wang, L. D.; Chammas, F.; Wuestefeld, T.; Lee, B. T. K.; Wong, S. L.

10.1101/2025.05.27.656284 — molecular biology — Posted on 2025-05-29

397 Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex

Harrison, G. A.; Shen, A.

10.1101/2025.05.29.656762 — microbiology — Posted on 2025-05-29

398 Encoding Cell Phenotype from Label-Free Imaging Flow Cytometry with Unsupervised Deep Learning

Gincley, B.; Khan, F.; Kumar, A.; Fuentes-Cabrera, M.; Guest, J. S.; Pinto, A. J.

10.1101/2025.05.29.656720 — microbiology — Posted on 2025-05-29

399 Dynamics and fermentation patterns of stool microbiota on simple carbon sources in in vitro batch cultures reveal dysbiosis in Crohn's disease.

Detman-Ignatowska, A.; Schiro, G.; Filip, R.; Samborowska, E.; Karczmarski, J.; Jakubowska, K.; Jarmakiewicz-Czaja, S.; Williams, A.; Hickman, N. R.; Laubitz, D.; Sikora, A.

10.1101/2025.05.29.656803 — microbiology — Posted on 2025-05-29

400 Proximity biotinylation at the host-Shigella interface reveals UFMylation as an antibacterial pathway.

Jimenez, A. T. L.; Thery, F.; Wright, K.; Painter, H.; Hoffmeister, S. T.; Jarche, L.; Benjamin, J.; van der Heden van Noort, G. J.; Brokatzky, D.; Gomes, M. C.; Miles, S. L.; Lobato-Marquez, D.; Rohde, J.; Pruneda, J. N.; Impens, F.; Mostowy, S.

10.1101/2025.05.29.656827 — microbiology — Posted on 2025-05-29

401 Making deep mutational scanning accessible: a cost-efficient approach to construct barcoded libraries for genes of any length

Jann, J.; Gagnon-Arsenault, I.; Pageau, A.; Dube, A. K.; Fijarczyk, A.; Durand, R.; Landry, C. R.

10.1101/2025.05.29.656836 — synthetic biology — Posted on 2025-05-29

402 CNAttention: an attention-based deep multiple-instance method for uncovering CNA signatures across cancers

Yang, Z.; Baudis, M.

10.1101/2025.05.26.656180 — bioinformatics — Posted on 2025-05-29

403 Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and their Housemates

Shepherd, P.; Elbe, A.; Lynch, B.; Lashnits, E.; Kirchdoerfer, R.

10.1101/2025.05.29.656645 — biochemistry — Posted on 2025-05-29

404 Integrating genomics, machine learning, and computer vision to understand growth traits in selectively bred snapper (Chrysophrys auratus)

Blommaert, J.; Bayer, P. E.; Ashton, D. T.; Samuels, G.; Jesson, L.; Wellenreuther, M.

10.1101/2025.05.29.656727 — genomics — Posted on 2025-05-29

405 MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos

Carey, C. M.; Parvez, S.; Brandt, Z. J.; Bisgrove, B. W.; Yates, C. J.; Peterson, R. T.; Gagnon, J. A.

10.1101/2025.05.27.656468 — genomics — Posted on 2025-05-29

406 A genomic catalog of Earth's bacterial and archaeal symbionts

Villada, J. C.; Vasquez, Y.; Szabo, G.; Walker, E. W.; Gutierrez, M. R.; Qin, S.; Varghese, N.; Eloe-Fadrosh, E. A.; Kyrpides, N.; SymGs data consortium, ; Visel, A.; Woyke, T.; Schulz, F.

10.1101/2025.05.29.656868 — genomics — Posted on 2025-05-29

407 Map functional insulators with cross-platform Hi-C meta-analysis

Xu, W.; Cui, J.; Zhang, S.; LU, L.; Liu, X.; Li, Y.; Jin, F.

10.1101/2025.05.26.656183 — genomics — Posted on 2025-05-29

408 Mechanisms and timing of programmed DNA elimination in songbirds

Dedukh, D.; Malinovskaya, L.; Kauzal, O.; Ridl, J.; Odnoprienko, D.; Karamysheva, T.; Vontzou, N.; Janko, K.; Suh, A.; Albrecht, T.; Torgasheva, A.; Reifova, R.

10.1101/2025.05.26.656170 — genetics — Posted on 2025-05-29

409 Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae.

Kothiwal, D.; Joseph, S.; Laloraya, S.

10.1101/2025.05.26.656218 — genetics — Posted on 2025-05-29

410 Rescue of tomato yellow leaf curl virus mutants with heterologous iterons through in planta evolution

Khemsom, K.; Ren, R.; Han, J.; Carvalho, C. P.; Snider, E. M.; Zhang, D.; Qu, F.

10.1101/2025.05.27.656274 — evolutionary biology — Posted on 2025-05-29

411 Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq

Tomuro, K.; Akaiwa, T.; Harada, A.; Kobayashi, K.; Shiina, N.; Kawaguchi, K.; Shichino, Y.; Iwasaki, S.

10.1101/2025.05.26.656194 — molecular biology — Posted on 2025-05-29

412 Picophytoplankton Implicated in Productivity and Biogeochemistry in the North Pacific Transition Zone

Key, R. S.; Coesel, S. N.; Gradoville, M. R.; Morales, R. L.; Farnelid, H.; Zehr, J.; Armbrust, V.; Durham, B.

10.1101/2025.05.29.656823 — microbiology — Posted on 2025-05-29

413 Continent-wide assessment of the strain-level diversity of Bradyrhizobium, a dominant soil bacterial genus

Bueno de Mesquita, C. P.; Olm, M. R.; Bissett, A.; Fierer, N.

10.1101/2025.05.29.656829 — microbiology — Posted on 2025-05-29

414 Single-Cell Phenotypic Heterogeneity Shapes Quorum Signaling Dynamics in Pseudomonas aeruginosa

Lange, D. G.; Litvinov, V.; Dar, D.

10.1101/2025.05.29.656822 — microbiology — Posted on 2025-05-29

415 Two birds with one stone: a novel potential antibiotic blocking IsdB-mediated heme extraction by Staphylococcus aureus with serendipitous hemoglobin left-shifting activity

Hijazi, S.; Marchesani, F.; Marchetti, M.; Buoli Comani, V.; Brear, P.; Campanini, B.; Ronda, L.; Faggiano, S.; Gianquinto, E.; Asgharpour Hassankiadeh, S.; Rolando, B.; Spyrakis, F.; Compari, C.; Lazzarato, L.; De Bei, O.; Frangipani, E.; Bettati, S.

10.1101/2025.05.29.656759 — microbiology — Posted on 2025-05-29

416 The Quantification of Drug Accumulation within Gram-Negative Bacteria

George, A.; Shivangi, F.; Bozan, A.; Spencer, K.; Terlecky, A. J.; Ahn, Y.-M.; Barnett, P. R.; Kreiswirth, B. N.; Freundlich, J. S.

10.1101/2025.05.28.656715 — microbiology — Posted on 2025-05-29

417 High-throughput screening reveals diverse lambdoid prophage inducers

Nair, G.; Fatima, R.; Hynes, A. P.

10.1101/2025.05.29.656831 — microbiology — Posted on 2025-05-29

418 IFITM3 deficient mice as a model for testing influenza virus vaccines

Eddy, A. C.; Speaks, S.; Hemann, E.; Yount, J.

10.1101/2025.05.26.656177 — immunology — Posted on 2025-05-29

419 Development and optimisation of Influenza C and Influenza D pseudotyped viruses

Marotta, M. G.; Neto, M. M.; Daly, J. M.; Maina, M.; van Diemen, P.; Everett, H.; Lucente, M. S.; Camero, M.; Montomoli, E.; Trombetta, C. M.; da Costa, K.; Temperton, N.

10.1101/2025.05.26.656172 — immunology — Posted on 2025-05-29

420 SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads

Huang, N.; Human Pangenome Reference Consortium, ; Li, H.

10.1101/2025.05.26.656191 — bioinformatics — Posted on 2025-05-29

421 A novel tripod probe and lateral flow test to improve CRISPR/Cas12a assay: benefits of branched probe based on trebler phosphoramidite modification

Safenkova, I. V.; Kamionskaya, M. V.; Ivanov, A. V.; Zherdev, A. V.; Dzantiev, B. B.

10.1101/2025.05.29.656603 — biochemistry — Posted on 2025-05-29

422 The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation

Lambrechts, L. S.; Reid, X. J.; Kambanis, L.; Luong, C.; Kobakhidze, E.; Daners, A.; Zhong, Y.; Patel, K.; Franck, C. K.; Sani, H. M.; Taylor, C.; Low, J. K.; Payne, R. J.; Mackay, J. P.

10.1101/2025.05.29.656505 — biochemistry — Posted on 2025-05-29

423 Establishing a Digital PCR-Based Reference Measurement Procedure for Monkeypox Virus: An Inter-laboratory Assessment and Standardization Study

Wang, X.; Li, H.; Guo, R.; Yang, Y.; Niu, C.; Zhou, S.; Gao, H.; Jin, X.; Wang, S.; Du, M.; Cheng, X.; Zhu, L.; Dong, L.

10.1101/2025.05.28.656494 — molecular biology — Posted on 2025-05-29

424 Whole blood proteome dynamics defines predictive diagnostic and prognostic signatures of cryptococcal infection

Geddes-McAlister, J.; Woods, M.; McAlister, J. A.; Segeren, L.; Silva, M.; Deyarmin, J.; Hakimi, A.; Hermanson, D.; Richter, J.; Samra, S.

10.1101/2025.05.29.656814 — microbiology — Posted on 2025-05-29

425 Gut3Gel as an in vitro model to investigate dietary modulation of the intestinal microbiota: An inulin supplementation case study

Antunes, M.; Jongen, L.; Mateen, A.; Sobral, J.; van Uden, S.; Suarez, N.; Pacheco, D.

10.1101/2025.05.29.656766 — microbiology — Posted on 2025-05-29

426 Nervous Necrosis Virus Capsid Protein Functions as a SUMO E3 Ligase to Activate MAVS-Dependent NF-κB Signaling

Zhang, W.; Chen, X.; Sun, B.; Yao, L.; Xiong, X.; Yi, M.; Jia, K.

10.1101/2025.05.29.656765 — microbiology — Posted on 2025-05-29

427 A mathematical framework to correct for compositionality in microbiome datasets

Forry, S. P.; Servetas, S. L.; Kralj, J. G.; Hunter, M. E.; Dootz, J. N.; Jackson, S. A.

10.1101/2025.05.29.656792 — microbiology — Posted on 2025-05-29

428 Varied mutual growth inhibition between commensal yeasts and strains

Pingault--Ordronneau, E.; Francois, A.; Ragoobeer, V.; Chambon, T.; Cockx, B.; Elias, A. J.; Szabo, D.; Gugolya, M.; Kreft, J.-U.; Cloteau, C.; Levercan, D.; Croyal, M.; Delhaye, T.; Rondeau, D.; Roullier, C.; Bertrand, S.; Picot, C.; Le Pape, P.; Batard, E.; Alvarez-Rueda, N.

10.1101/2025.05.29.656793 — microbiology — Posted on 2025-05-29

429 Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens

Rysava, M.; Palkovicova, J.; stredanska, k.; Schwarzerova, J.; Jakubickova, M.; Cejkova, D.; Aytan-Aktug, D.; Otani, S.; Dolejska, M.

10.1101/2025.05.29.656840 — microbiology — Posted on 2025-05-29

430 A detailed study Biofilm forming Polyextremophilic Firmicutes from the Himalayas and exploration of their plant growth promoting potential.

ROY, B.; Maitra, D.; Chakraborty, A.; Basak, P.; Chaudhuri, I.; Ghosh, J.; Mitra, A. K.

10.1101/2025.05.29.656832 — microbiology — Posted on 2025-05-29

431 A CRISPR/Cas9-based system using dual-sgRNAs for efficient gene deletion in Mycobacterium abscessus

Li, L.; Wang, D.; Li, X.; Hu, Y.; Bao, S.; Deng, T.; Wang, Q.

10.1101/2025.05.28.656731 — microbiology — Posted on 2025-05-29

432 Immunological evaluation in African Green Monkeys of two nasal vaccine candidates to induce a broad immunity against coronaviruses

Lazo, L.; Suzarte Portal, E.; Vazquez-Blomquist, D.; Rodriguez-Alonso, I.; Perez Fuente, Y.; Puente Perez, P.; Martinez Castillo, R.; Urquiza Noa, D.; Amaya Izquierdo, R.; Bequet-Romero, M.; Romero Fernandez, Y.; Hernandez-Delgado, J.; Chen, R.; Li, W.; Guillen, G.; Perera, Y.; Lobaina, Y.; Hermida, L.

10.1101/2025.05.28.656401 — immunology — Posted on 2025-05-29

433 Predictive Modeling of Immune Escape and Antigenic Grouping of SARS-CoV-2 Variants

Nasir, A.; Lee, D.; Avena, L. E.; Montes Berrueta, D.; Speidel, T.; Wu, K.; Budigi, Y.; Carfi, A.; Stewart-Jones, G. B. E.; Edwards, D. K.

10.1101/2025.05.28.656328 — immunology — Posted on 2025-05-29

434 From Hype to Health Check: Critical Evaluation of Drug Response Prediction Models with DrEval

Bernett, J.; Iversen, P.; Picciani, M.; Wilhelm, M.; Baum, K.; List, M.

10.1101/2025.05.26.655288 — bioinformatics — Posted on 2025-05-29

435 Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

Dillard, L. J.; Calabrese, G. M.; Mesner, L. D.; Farber, C. R.

10.1101/2024.05.20.594981 — genomics — Posted on 2025-05-29

436 Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction

Schipper, K.; Tamminga, S. M.; Murner, N.; Davies, M. A.; Berkhout, P.; Bessen, D. E.; Hendriks, A.; Korotkova, N.; Pannekoek, Y.; van Sorge, N. M.

10.1101/2024.11.04.621835 — microbiology — Posted on 2025-05-29

437 Marker genes for predicting cytokine release syndrome in vitro before CAR T cell infusion

Chen, M.; Wu, T.; Hu, Y.; Liu, Q.; Chen, M.; Zhang, J.; Du, Y.; Ouyang, F.; Huang, Y.

10.1101/2025.05.26.655341 — immunology — Posted on 2025-05-29

438 Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis

Barath, A. S.; Dheer, A.; Dale, E.; Goche, F.; Nguyen, T. T. L.; Montier, L.; Akter, M.; Peshoff, M.; Qi, F.; Umpierre, A. D.; Bosco, D. B.; Haruwaka, K.; Sah, R.; Wu, L.-J.

10.1101/2025.05.26.656163 — neuroscience — Posted on 2025-05-29

439 Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

Dovek, L.; Ahmadi, M.; Marrero, K.; Zagha, E.; Santhakumar, V.

10.1101/2024.08.21.608983 — neuroscience — Posted on 2025-05-29

440 Counteracting memories acquired in parallel by limited pairings in eyeblink conditioning

Iwase, R.; Kawaguchi, S.-y.

10.1101/2025.05.26.656060 — neuroscience — Posted on 2025-05-29

441 A systems-level machine learning approach uncovers therapeutic targets in clear cell renal cell carcinoma

Estevez, S. R.; Baltusyte, G.; Youssef, G.; Han, N.

10.1101/2025.05.26.656158 — systems biology — Posted on 2025-05-29

442 Subtype-Specific Freezing of Gait Detection Strategies via Feature-Masked-Based CNN

Yu, X.; Martens, K. E.; Arami, A.

10.1101/2025.05.26.656145 — bioengineering — Posted on 2025-05-29

443 Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes.

Chuah, J. J. Y.; Daugherty, M. R.; Smith, D. M.

10.1101/2024.05.21.595185 — biochemistry — Posted on 2025-05-29

444 Methyl Nicotinate Is a Novel Geroprotective Compound That Promotes Mitochondria Dependent Lifespan Extension

Mingtong, G.; Alfatah, M.

10.1101/2025.05.26.656117 — genetics — Posted on 2025-05-29

445 Environmental drivers of Ixodes ricinus tick population dynamics: mechanistic modelling using longitudinal field surveys and climate data

Kim, Y.; Jaulhac, B.; Vesga, J. F.; Zilliox, L.; Boulanger, N.; Edmunds, J.; Metras, R.

10.1101/2024.06.06.597751 — ecology — Posted on 2025-05-29

446 Olfactory bulb and cortex activity reflects subjective odor intensity perception rather than concentration

Norden, F.; Zanettin, I.; Lundqvist, M.; Arshamian, A.; Lundstrom, J. N.

10.1101/2025.05.26.656087 — neuroscience — Posted on 2025-05-29

447 Machine Learning Discovers Numerous New Computational Principles Supporting Elementary Motion Detection

Poleg-Polsky, A.

10.1101/2025.05.26.656164 — neuroscience — Posted on 2025-05-29

448 Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models

Brunialti, E.; Villa, A.; Szego, E. M.; La Vitola, P.; Drago, D.; Pavlovic, R.; Fontana, L.; Tuna, D.; Panzeri, A.; Meda, C.; Rondinone, O.; Pitasi, M.; Miozzo, M.; Andolfo, A.; Di Monte, D. A.; Ciana, P.

10.1101/2025.05.26.656111 — neuroscience — Posted on 2025-05-29

449 CoREST Complex Stabilizes MYC Protein to Promote Cancer Cell Genome Stability

Khan, A. A.; Kim, S.; Sidrat, T.; Byun, J.; Aptekmann, A. A.; Dalerba, P. D.; Zakrzewski, J. L.; Shin, J.; Ryu, B.

10.1101/2024.12.23.630174 — cancer biology — Posted on 2025-05-29

450 The TMRCA of general genealogies in populations with deterministically varying size

Wemces, A. H.; Penaloza, L.; Steinruecken, M.; Siri-Jegousse, A.

10.1101/2024.09.19.613917 — evolutionary biology — Posted on 2025-05-29

451 Testing for the genomic footprint of conflict between life stages in an angiosperm and moss species

Yuan, M.; Kollar, L. M.; Sacchi, B. M.; Carey, S. B.; Choudhury, B. I.; Jones, T.; Grimwood, J.; Barrett, S. C.; McDaniel, S. F.; Wright, S. I.; Stinchcombe, J. R.

10.1101/2024.10.04.613734 — evolutionary biology — Posted on 2025-05-29

452 Amino acid sensing by the α-cell mitochondrial phosphoenolpyruvate cycle regulates intracellular Ca2+ levels independently of glucagon secretion

Jin, E.; Foster, H. R.; Potapenko, E.; Huang, S. M.; Dong, X.; Hughes, J. W.; Merrins, M. J.

10.1101/2025.05.26.656009 — cell biology — Posted on 2025-05-29

453 Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation

Swann, J. W.; Fung, J. H.; Chen, Z.; Olson, O. C.; Collins, A.; Lhakhang, T.; Proven, M. A.; Zhang, R.; Rabadan, R.; Passegue, E.

10.1101/2025.05.28.656712 — cell biology — Posted on 2025-05-29

454 Sialidases derived from Gardnerella vaginalis and Prevotella Timonensis remodel the sperm glycocalyx and impair sperm function

Dohadwala, S.; Shah, P.; Farrell, M. K.; Politch, J.; Marathe, J.; Costello, C. E.; Anderson, D. J.

10.1101/2025.02.01.636076 — immunology — Posted on 2025-05-29

455 Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection

Alhussien, M.; Vikkula, H. K.; Klinger, R.; Zenner, C.; Frueh, S. P.; Negi, R.; von Heyl, T.; Schleibinger, S.; Brunner, M.; Berghof, T. V.; Avolio, L.; Reich, A.; Schade, B.; Aboukhadra, B.; Rautenschlein, S.; Preisinger, R.; Sid, H.; Schusser, B.

10.1101/2025.01.24.634794 — immunology — Posted on 2025-05-29

456 Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Habib, R.; Roark, R. S.; Li, H.; Connell, A. J.; Hogarty, M. P.; Wagh, K.; Wang, S.; Marchitto, L.; Skelly, A. N.; Carey, J. W.; Sowers, K. J.; Ayyanathan, K.; Plante, S. J.; Bibollet-Ruche, F.; Park, Y.; Agostino, C. J.; Singh, A.; Martella, C. L.; Lewis, E.; Rando, J. M.; Chohan, N.; Lora, J.; Ding, W.; Campion, M. S.; Zhao, C.; Liu, W.; Li, Y.; Li, X.; Liang, B.; Chowdhury, R. R.; Amereh, K.; Van Itallie, E.; Sheng, Z.; Ghosh, A. R.; Bar, K. J.; Williams, W. B.; Wiehe, K.; Saunders, K. O.; Edwards, R. J.; Cain, D. W.; Lewis, M.; Batista, F. D.; Burton, D. R.; Andrabi, R.; Kulp, D. W.; Hayne

10.1101/2025.05.03.652068 — immunology — Posted on 2025-05-29

457 Multilayered regulation by RNA thermometers enables precise control of Cas9 expression

Phillips, E. K.; Klingeman, D. M.; Guss, A. M.; Eckert, C. A.; Alexander, W. G.

10.1101/2025.05.12.651296 — synthetic biology — Posted on 2025-05-29

458 Targeting Semaphorin 7a signaling in preclinical models of estrogen receptor-positive breast cancer

Steinmetz, R. N.; Wessells, V.; Fairchild, H.; Lyons, T. R.

10.1101/2025.05.21.655360 — cancer biology — Posted on 2025-05-29

459 Single-cell molecular subtyping reveals novel intratumor heterogeneity in human Basal-like breast cancer

Li, J.; Gao, Y.; Guo, S.; Zhang, S.; Yu, W.; Liu, K.

10.1101/2024.06.02.597060 — bioinformatics — Posted on 2025-05-29

460 Reflection Knockoffs via Householder Reflection: Applications in Proteomics and Genetic Fine Mapping

Guan, Y.; Levy, D.

10.1101/2025.01.16.633369 — bioinformatics — Posted on 2025-05-29

461 Allopatric speciation in cattails: Genomics reveal bottlenecks, balancing selection, and adaptive introgressions in Typha, a wetland ecosystem engineer

Aleman, A.; Shafer, A. B. A.; Freeland, J. R.; Dorken, M.

10.1101/2024.07.02.601742 — evolutionary biology — Posted on 2025-05-29

462 Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks

Kosinski, J.; Gilep, K.; Obarska-Kosinska, A.

10.1101/2024.12.03.626671 — molecular biology — Posted on 2025-05-29

463 The shape of attention: How cognitive goals sculpt cortical representation of speech.

Huet, M.-P.; Elhilali, M.

10.1101/2025.05.22.655464 — neuroscience — Posted on 2025-05-29

464 Genetic regulation of fatty acid content in adipose tissue

Yan, X.; Roberts, A. L.; El-Sayed Moustafa, J. S.; Villicana, S.; Al-Hilal, M.; Tomlinson, M.; Menni, C.; Sanders, T. A.; Freydin, M. B.; Bell, J. T.; Small, K. S.

10.1101/2025.05.28.655990 — genetics — Posted on 2025-05-29

465 CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS

Almeida-Santos, G.; Santiago-Carvalho, I.; Almeida, F. M.; Bomfim, C. C. B.; Santos e Silva, J. C.; Cantarini, D. G.; Silva, C. R.; Ribeiro, M. S.; Macedo, B. d. G.; Raeder, P. H. L.; Teixeira-Xavier Junior, J.; Alvarez, J. M.; Hirata, M. H.; Coutinho-Silva, R.; Robson, S. C.; Amaral, E. P.; Lasunskaia, E.; Lima, M. R. D. I.

10.1101/2025.05.28.656614 — immunology — Posted on 2025-05-29

466 Transcranial direct current stimulation over the frontal eye field has no effect on visual search performance

Peylo, C.; Albrecht, C.; Homann, R. G.; Richter, J.; Dornier, M. A.; Ehrat, M. S.; Loeb, F. L.; Manz, S.; Gaeta, M. P.; Rieger, C.; Tafelmaier, J. C.; Sauseng, P.

10.1101/2025.05.27.656327 — neuroscience — Posted on 2025-05-29

467 The SAFE Labs Handbook: community-driven commitments for group leaders to improve lab culture

Dona, E.; Gahan, J. M.; Lau, P.; Jeschke, J.; Ott, T.; Reinhard, K.; Sinigaglia, C.; Treur, J. L.; Vogl, T.; Bugeon, S.; Mariotti, L.; Rossi, F. F.; Coen, P.

10.1101/2025.05.27.655799 — scientific communication and education — Posted on 2025-05-29

468 DoggifAI: a transformer based approach for antibodycaninisation

Grabarczyk, D.; Kocikowski, M.; Parys, M.; Houston, D.; Hupp, T.; Alfaro, J. A.; Cohen, S.

10.1101/2025.05.28.656573 — bioinformatics — Posted on 2025-05-29

469 mt.surv: Multi-Threshold Survival Analysis for Associating Continuous Predictor Variables with Time-to-Event Outcomes

Loncar, A. J.; Hoyd, R.; Liu, Y.; Dravillas, C.; Dhrubo, D.; Spakowicz, D. J.

10.1101/2025.05.29.656703 — bioinformatics — Posted on 2025-05-29

470 obABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors

10.1101/2025.05.27.656269 — biochemistry — Posted on 2025-05-29

471 The impact of background selection in mutation-selection-drift balance models of complex trait evolution

Li, X.; Berg, J. J.

10.1101/2025.05.27.656342 — evolutionary biology — Posted on 2025-05-29

472 The impact of background selection in mutation-selection-drift balance models of complex trait evolution

Li, X.; Berg, J. J.

10.1101/2025.05.27.656342 — evolutionary biology — Posted on 2025-05-29

473 Evolution of ultraconserved elements by indels

Biller, P.

10.1101/2025.05.27.656252 — evolutionary biology — Posted on 2025-05-29

474 Computational design of monomeric Fc variants with distinct pH-responsive FcRn-binding profiles

Jeon, J.-Y.; Lee, H.; Choi, S.; Suh, S.; Im, S.-B.; Kim, Y.-G.; Ku, B. M.; Ahn, M.-J.; Jeong, B.-s.; Oh, B.-H.

10.1101/2025.05.26.656075 — bioengineering — Posted on 2025-05-29

475 Genetically Programmable Adhesive Protein Hydrogels for Sealing Perforating Corneal Trauma

Xu, L.; Yi, Q.; Hu, P.; Yu, Y.; Huang, Y.; Ye, Y.; Chen, H.; Fok, H. K. F.; Zhao, P.; Wu, X.; Kou, S.; Zhou, Z.; Sun, F.; Long, D.

10.1101/2025.05.26.656098 — bioengineering — Posted on 2025-05-29

476 Mitochondrial presequences harbor variable strengths to maintain organellar function

Yan, Y.; Erdenepurev, B.; Collinson, I.; Niemi, N. M.

10.1101/2025.05.26.655807 — biochemistry — Posted on 2025-05-29

477 Coordinated adaptive changes in insulin, insulin receptor, and inceptor genes in hystricognath rodents

Hilario, M.; Magallanes, M. E.; Opazo, J. C.; Lessa, E. P.

10.1101/2025.05.26.656141 — evolutionary biology — Posted on 2025-05-29

478 Spatial covariation between wild boars and other mammals in peri-urban landscapes: insights for management from southern France

Barachin, L.; Dezeure, J.; Said, S.; Mathevet, R.; Baubet, E.; Chamaille-Jammes, S.

10.1101/2025.05.26.656147 — ecology — Posted on 2025-05-29

479 What if wildlife health surveillance was not just for veterinarians? - Opportunistic use of population monitoring by camera traps for syndromic surveillance of the Eurasian lynx (Lynx lynx)

Lenglin, L.; Chenesseau, D.; Blin, L.; BASTIAN, S.; Borel, S.; Ryser-Degiorgis, M.-P.; Zimmermann, F.; Toulet, N.; Lemberger, K.; Gourlay, P.; Decors, A.

10.1101/2025.05.26.656112 — ecology — Posted on 2025-05-29

480 WITHDRAWN: Yeast strain development for enhanced polyphosphate production

Fees, J.; Greven, L.; Buhl, E. M.; Blank, L. M.

10.1101/2025.03.19.642307 — molecular biology — Posted on 2025-05-29

481 Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis

Neppelenbroek, S.; Wortel, C. M.; van Rijswijck, D. M. H.; Wetzels, M. J. A. L.; Kim, R. Q.; Levarht, N. E. W.; Heck, A. J. R.; de Vries-Bouwstra, J. K.; Fehres, C. M.; Toes, R. E. M.; Scherer, H. U.

10.1101/2025.05.26.656088 — immunology — Posted on 2025-05-29

482 Field-Programmable Gate Array Based Ultra-Low Power Discrete Fourier Transforms for Closed-Loop Neural Sensing

Yang, R.; Orser, H. D.; Ludwig, K. A.; Coventry, B. S.

10.1101/2025.02.13.637868 — neuroscience — Posted on 2025-05-29

483 Multi-Stable Bimodal Perceptual Coding within the Ventral Premotor Cortex

Andrade-Ortega, B.; Diaz, H.; Bayones, L.; Alvarez, M.; Zainos, A.; Rivera-Yoshida, N.; Franci, A.; Romo, R.; Rossi-Pool, R.

10.1101/2024.12.11.628069 — neuroscience — Posted on 2025-05-29

484 Differential contributions of low-frequency phase and power in crossmodal temporal prediction: A MEG study

Burke, R.; Daume, J.; Schneider, T. R.; Engel, A. K.

10.1101/2025.05.26.656128 — neuroscience — Posted on 2025-05-29

485 Maternal immune activation during the lactational period alters offspring behavior, reproductive development, and immune function in mice

Merengueli, J. A.; Kentner, A. C.

10.1101/2025.05.26.656156 — neuroscience — Posted on 2025-05-29

486 Effects of Three Natural Dietary Compounds on Insect Pests

Cabello, T.; Gamez, M.

10.1101/2025.05.23.655814 — zoology — Posted on 2025-05-29

487 From lab to field: analyses of genome-edited bacterial blight resistant rice

Frommer, W. B.; Loo, E. P.; Huguet-Tapia, J. C.; Selvaraj, M.; Stiebner, M.; Killing, B.; Buchholzer, M.; Schepler-Luu, V.; Hartwig, T.; Valdez Gutierrez, S.; Rast-Somssich, M. I.; Szurek, B.; Tohme, J.; Charraviaga, P.; White, F. F.; Yang, B.

10.1101/2025.05.26.656110 — plant biology — Posted on 2025-05-29

488 Characterization of the maize (Zea mays)-Ustilago maydis interaction in a warming climate

Schwarz, C. G.; Hartmann, F.; Zier, C.; van der Linde, K.

10.1101/2025.05.26.656155 — plant biology — Posted on 2025-05-29

489 Influence of Substrate Elastic Modulus on Cell Shape and Displacement During the Motility Cycle

Nagai, A.; Kuwabara, H.; Moriyama, Y.; Mitsui, T.

10.1101/2025.05.26.656039 — biophysics — Posted on 2025-05-29

490 A deeper study on propionic acid-related inhibition during anaerobic digestion: insights on methane production and identification of biomarker candidates for an early warning

Liu, X.; Soulard, C.; Jamilloux, V.; Pauss, A.; Andre, L.; Ribeiro, T.; Guerin-Rechdaoui, S.; Rocher, V.; Lacroix, C.; Bureau, C.; Midoux, C.; Chapleur, O.; Bize, A.; Roose-Amsaleg, C.

10.1101/2025.05.26.656080 — bioengineering — Posted on 2025-05-29

491 Simple, fast, low-cost method to produce transgenic pollen

Wang, H.; Zhang, Y.; Qu, W.; Zhang, X.; Qu, H.

10.1101/2025.05.26.655774 — bioengineering — Posted on 2025-05-29

492 Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors

Mishra, S.; Yadav, M. K.; Dalal, A.; Ganguly, M.; Yadav, R.; Sawada, K.; Tiwari, D.; Roy, N.; Banerjee, N.; Fung, J. N.; Marallag, J.; Cui, C. S.; Li, X. L.; Lee, J. D.; Dsouza, C. A.; Saha, S.; Sarma, P.; Rawat, G.; Zhu, H.; Khant, H. A.; Clark, R. J. J.; Sano, F. K.; Banerjee, R.; Woodruff, T. M.; Nureki, O.; Gati, C.; Shukla, A. K.

10.1101/2025.05.26.656101 — biochemistry — Posted on 2025-05-29

493 Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry

Shamorkina, T. M.; Paneda, L. P.; Kadava, T.; Schulte, D.; Pribil, P. A.; Heidelberger, S.; Narlock-Brand, A. M.; Yannone, S. M.; Snijder, J.; Heck, A. J. R.

10.1101/2025.05.26.656138 — biochemistry — Posted on 2025-05-29

494 Rampant transitions between dispersal syndromes duringangiosperm evolution

de Frens, D.; Bakker, F. T.; Sauquet, H.; Stephens, R. E.; Onstein, R. E.

10.1101/2025.05.26.656093 — evolutionary biology — Posted on 2025-05-29

495 Reconfiguration of Brain-Wide Neural Activity After Early Life Adversity

Uselman, T. W.; Jacobs, R. E.; Bearer, E. L.

10.1101/2023.09.10.557058 — neuroscience — Posted on 2025-05-29

496 Efficient learning and intrinsic noise filtering in recurrent spiking neural networks trained with e-prop

Noe, D.; Yamamoto, H.; Katori, Y.; Sato, S.

10.1101/2025.05.25.656058 — neuroscience — Posted on 2025-05-29

497 Meningeal vascular Aβ deposition associates with cerebral hypoperfusion and compensatory collateral remodeling

Kaloss, A. M.; Browning, J. L.; Li, J.; Pan, Y.; Watsen, S.; Sontheimer, H.; Theus, M. H.; Olsen, M. L.

10.1101/2025.02.05.635937 — neuroscience — Posted on 2025-05-29

498 3BTRON: A Blood-Brain Barrier Recognition Network

Fletcher-Lloyd, N. V.; Bravo-Ferrer, I.; Gaasdal-Bech, K.; Diaz Castro, B.; Barnaghi, P.

10.1101/2025.02.12.637854 — neuroscience — Posted on 2025-05-29

499 The striatal heterogeneous nuclear ribonucleoprotein H mRNA targetome associated with methamphetamine administration and behavior

Ruan, Q. T.; Lynch, W. B.; Cole, R. H.; Rieger, M. A.; Baskin, B. M.; Miracle, S. A.; Beierle, J. A.; Yao, E. J.; Cox, J. W.; Kandola, A.; Richardson, K. T.; Chen, M. M.; Kelliher, J. C.; Babbs, R. K.; Ash, P. E. A.; Wolozin, B.; Szumlinski, K. K.; Johnson, W. E.; Dougherty, J. D.; Bryant, C. D.

10.1101/2021.07.06.451358 — neuroscience — Posted on 2025-05-29

500 Gene network architecture, mutation and selection collectively drive developmental pattern evolvability and predictability

Booth, H.; Hadjivasiliou, Z.

10.1101/2024.12.23.630099 — systems biology — Posted on 2025-05-29

501 Preclinical Prediction of Resistance and Optimization of Sequential Therapy for ALK-positive Lung Cancer Using Next-generation ALK Inhibitors

Takei, Y.; Kuroiwa, H.; Arai, C.; Doi, Y.; Semba, K.

10.1101/2025.05.26.656085 — cancer biology — Posted on 2025-05-29

502 Kinetic Insights into Photoinduced Monomer-Dimer Conversion and Activation of Orange Carotenoid Protein

Tokashiki, T.; Ohata, T.; Tokonami, S.; Nakaosne, Y.; Terazima, M.

10.1101/2025.05.26.656073 — biophysics — Posted on 2025-05-29

503 A Method for Predicting Enzyme Substrate Specificity Residues Using Homologous Sequence Information

Mori, S.; Niide, T.; Toya, Y.; Shimizu, H.

10.1101/2025.05.25.656053 — bioengineering — Posted on 2025-05-29

504 Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries

Hanna, A. R.; Shepherd, S. J.; Datto, G. A.; Navarro, I. B.; Ricciardi, A.; Padilla, M.; Srikumar, N.; Zhang, S.; Yamagata, H.; Meng, N.; Buser, J. R.; MITCHELL, M.; Issadore, D.

10.1101/2025.05.26.656157 — bioengineering — Posted on 2025-05-29

505 Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity

Lee, J.; Jeon, E. Y.; Yu, L.; Jo, H.-Y.; Kim, S. C.; Park, W.-Y.; Park, H.-Y.; Zhao, S.; Choi, M.

10.1101/2024.12.18.629144 — genetics — Posted on 2025-05-29

506 Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance

Collins, M. A.; Friedrich, C.; Elcheikhali, M.; Stewart, P.; Derks, J.; Connors Stewart, T.; Altig, K.; Melloni, A.; Petelski, A.; Oakley, D.; Hyman, B.; Slavov, N.

10.1101/2025.05.29.656728 — neuroscience — Posted on 2025-05-29

507 AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers

Lee, J. W.; Shi, J.; Barrantes, J.; Chaurasia, P.; Kim, S.; Cruz-Gomez, S.; Yang, C.; Gu, J.; Zhao, H.; Zhao, D.; Schiff, B.; Roche, A.; Perry, E. B.; Townsend, J. P.; Kupfer, G. M.; Politi, K.; Golemis, E.; Burtness, B.

10.1101/2025.05.28.656693 — cancer biology — Posted on 2025-05-29

508 Photoreceptor loss does not recruit neutrophils despite strong microglial activation

Power, D.; Elstrott, J.; Schallek, J.

10.1101/2024.05.25.595864 — immunology — Posted on 2025-05-29

509 Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety and degeneracy at the heart of learning.

Confavreux, B.; Harrington, Z.; Kania, M.; Ramesh, P.; Krouglova, A. N.; Bozelos, P.; Macke, J. H.; Saxe, A. M.; Goncalves, P. J. H.; Vogels, T. P.

10.1101/2025.05.28.656584 — neuroscience — Posted on 2025-05-29

510 Biomechanics of static roll posture control by body flexion in adult zebrafish

Nagaoka, R.; Katayama, T.; Higashijima, S.-i.; Tanimoto, M.

10.1101/2025.05.26.655680 — zoology — Posted on 2025-05-29

511 CLUSTERING SPERM: A STATISTICAL APPROACH TO IDENTIFY SPERM MORPH NUMBERS IN THE DROSOPHILA OBSCURA SPECIES GROUP

Messer, F.; White-Cooper, H.

10.1101/2025.05.29.656784 — zoology — Posted on 2025-05-29

512 Kinetic Modeling of Covalent Inhibition: Effects of Rapidly Fluctuating Intermediate States

Ghaby, K.; Roux, B.

10.1101/2025.05.28.656658 — biophysics — Posted on 2025-05-29

513 Bioinformatics classification of the MgtE Mg2+ channel and de novo protein design for the stabilization of its novel subclass

Zhao, Z.; Omae, K.; Iwasaki, W.; Zhang, Z.; Pan, F.; Lee, E.-J.; Hattori, M.

10.1101/2025.05.26.656215 — biophysics — Posted on 2025-05-29

514 AlphaFold modeling of polyubiquitin complexes and covalently linked proteins

Fabian, B.; Stuke, J. F. M.; Heinz, M.; Hummer, G.

10.1101/2025.05.27.656350 — bioinformatics — Posted on 2025-05-29

515 Decoupled Information Theoretic Feature Selection for Rapid Protein Key Tuning Residue Identification

Saeed, H.; Yang, A.; Huang, W.

10.1101/2025.05.28.653817 — bioinformatics — Posted on 2025-05-29

516 REGULATION OF HDL DYSFUNCTIONALITY BY PHOSPHATIDYLETHANOLAMINE LINKS POLY-UNSATURATED FATTY ACIDS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASES

Taradeh, M.; Hardy, L. M.; Dahik, V. D.; Lhomme, M.; Wang, H.; Reydellet, C.; Materne, C.; KC, P.; Bun, E.; Clemessy, M.; Pais-De-Barros, J.-P.; Galier, S.; Frisdal, E.; Durand, H.; Ponnaiah, M.; El Khoury, P.; Villard, E. F.; Lesnik, P.; Gallo, A.; Kappeler, L.; Giral, P.; Bruckert, E.; Masson, D.; Guerin, M.; Kontush, A.; Guillas, I.; Le Goff, W.

10.1101/2025.05.27.656492 — cell biology — Posted on 2025-05-29

517 Experimental Genetics Validation of Plasmodium falciparum Gametogenesis Essential Protein 1 (GEP1) as a Transmission Blocking Target

Huppertz, F.; Siebeck Caturelli, M.; Lehmann, L.; Kurth, F.; Maier, A. G.; Matuschewski, K.

10.1101/2025.05.28.656680 — molecular biology — Posted on 2025-05-29

518 GNAT family Pat2 lysine acetylation of glycerol kinase and its key role in glycerol metabolism in hypersaline-adapted archaea

Judd, H. N.; Sanchez, K. M.; Dublino, L. S.; Zhang, G. J.; Gal, D.; Couto-Rodriguez, R. L.; Maupin-Furlow, J. A.

10.1101/2025.05.27.656527 — microbiology — Posted on 2025-05-29

519 eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules

Purdy, S. C.; Matlin, K.; Alderman, C.; Baldwin, A.; Shrivastava, N.; Dutta, S.; Webb, K. J.; Wolin, A.; Boulton, D. P.; Kapali, J.; Landau, J. D.; Lewis, M. T.; Caino, M. C.; Costello, J. C.; Old, W.; Wang, X.; Zhao, R.; Ford, H. L.; Mukherjee, N.

10.1101/2025.05.29.656739 — cancer biology — Posted on 2025-05-29

520 The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence

Repele, A.; Handzlik, J. E.; Samarawickrama, N.; Loh, Y. L.; Manu, M.

10.1101/2025.05.25.656046 — developmental biology — Posted on 2025-05-29

521 Polar localization of putative phospholipid transporters in Escherichia coli

Tan, W. B.; Chong, Z.-S.; Cheong, J. W. M.; Yeow, J.; Chng, S.-S.

10.1101/2025.04.17.649288 — microbiology — Posted on 2025-05-29

522 Quantification of grapevine yield losses as a function downy mildew severity on foliage and cluster

Fabre, F.; Delbac, L.; Poeydebat, C.; Zaffaroni, M.

10.1101/2024.02.28.582447 — microbiology — Posted on 2025-05-29

523 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia

Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.

10.1101/2024.08.10.607441 — pathology — Posted on 2025-05-29

524 Prevalence of Bovine Fasciolosis and Identification of Risk Factors in Bahir Dar, Ethiopia

Mesfin, T.; Solomon, T.; Temesgen, A. B.

10.1101/2024.08.07.606800 — pathology — Posted on 2025-05-29

525 Caspase-8 is a novel modulator of Homologous Recombination Repair in response to ionizing radiations

Barila, D.; Contadini, C.; Ferri, A.; Di Girolamo, C.; Cirotti, C.; Fiscon, G.; Paci, P.; Marzullo, M.; Gentileschi, M.; Yamamoto, T.; Strauss, R.; Del Bufalo, D.; Ciapponi, L.

10.1101/2025.05.26.656091 — cancer biology — Posted on 2025-05-29

526 ArtiDock: accurate Machine Learning approach to protein-ligand docking optimized for high-throughput virtual screening

Voitsitskyi, T.; Koleiev, I.; Stratiichuk, R.; Kot, O.; Kyrylenko, R.; Savchenko, I.; Husak, V.; Yesylevskyy, S.; Starosyla, S.; Nafiiev, A.

10.1101/2024.03.14.585019 — bioinformatics — Posted on 2025-05-29

527 H3K4me2 orchestrates H2A.Z and Polycomb repressive marks in Arabidopsis

Noyori, T.; Mori, S.; Oya, S.; Nishio, H.; Kudoh, H.; Inagaki, S.; Kakutani, T.

10.1101/2025.05.26.656066 — genetics — Posted on 2025-05-29

528 Functionally significant, novel variants of BMP4 are associated with isolated congenital heart disease

Maddhesiya, J.; Dixit, R.; Kumar, A.; Mohapatra, B.

10.1101/2025.05.26.656099 — genetics — Posted on 2025-05-29

529 Neuronal activity induces aggrecan expression to drive perineuronal net formation in cortical neurons

Nakayama, K.; Mubuchi, A.; Miyata, S.

10.1101/2025.05.29.656756 — neuroscience — Posted on 2025-05-29

530 Sez6L2 autoimmunity induces cerebellar ataxia in mice

Reyes-Sepulveda, C. J.; Granato, J.; Randolph, J.; Ryan, A. T.; Hobbins, A.; Stout, A.; Li, H.; Hammond, J. W.

10.1101/2025.05.28.656724 — neuroscience — Posted on 2025-05-29

531 The neural processes of illusory occlusion in object recognition

Ramirez-Haro, A.; Moerel, D.; Quek, G. L.; Varlet, M.; Grootswagers, T.

10.1101/2025.05.28.656741 — neuroscience — Posted on 2025-05-29

532 Global propagation of genetic perturbation effects through genome-wide stoichiometry conservation architecture

Chiba, G.; Kamei, K.-i. F.; Oda, A. H.; Ohta, K.; Wakamoto, Y.

10.1101/2025.05.26.656078 — systems biology — Posted on 2025-05-29

533 Inference and prediction for random walkmodels in biology

Simpson, M. J.; Plank, M. J.

10.1101/2025.05.25.656057 — systems biology — Posted on 2025-05-29

534 A BRC1-modulated switch in auxin transport accounts for the competition between Arabidopsis axillary buds

Nahas, Z.; Bridgen, A. J.; Loman, T. E.; Dillon, J.; Abley, K.; Cano-Ramirez, D. L.; Ticchiarelli, F.; Seale, M.; Locke, J. C. W.; Leyser, O.

10.1101/2025.05.26.656108 — plant biology — Posted on 2025-05-29

535 Optimization of Crop Rotation Calendar to Maximize System-Level Productivity under Climate Change

Murakami, K.; Iizumi, T.

10.1101/2025.05.25.656037 — plant biology — Posted on 2025-05-29

536 Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer

Jiang, Y.; Cheng, S.; Li, L.; Fraidenburg, M.; Kim, I. Y.; Deng, S.; Mu, P.

10.1101/2025.05.26.656166 — cancer biology — Posted on 2025-05-29

537 Preclinical Prediction of Resistance and Optimization of Sequential Therapy for ALK-positive Lung Cancer Using Next-generation ALK Inhibitors

Semba, K.; Takei, Y.; Kuroiwa, H.; Arai, C.; Doi, Y.

10.1101/2025.05.26.656085 — cancer biology — Posted on 2025-05-29

538 Multimodal gene and targeted drug therapy for chronic myelogenous leukemia: Computational target analysis and therapeutic validation

Lugin, M. L.; Lei, W.; Lee, R. T.; Chung, J. Y.; Katritsis, N. M.; Hwang, W.; Fleischman, A. G.; Han, N.; Kwon, Y. J.

10.1101/2025.05.26.656072 — cancer biology — Posted on 2025-05-29

539 Hierarchical prediction and perturbation of chromatin organization reveal how loop domains mediate higher-order architectures

Wei, J.; Xue, Y.; Gao, Y. Q.

10.1101/2025.05.25.656045 — bioinformatics — Posted on 2025-05-29

540 Unraveling novel insights into dual-species cariogenic biofilm formation: a comparative analysis on natural vs artificial bioengineered dentin models

Ortiz, J.; Alvarez, S.; Aguayo, S.

10.1101/2025.05.24.655910 — bioengineering — Posted on 2025-05-29

541 Multivalent Lipid MVL5 Micellar Nanoparticles Exhibit Dramatically Increased Loading of Paclitaxel with PEGylation Enhancing Human Cancer Cell Penetration Depth and Cytotoxicity

Fisher, W. S.; Ghasemizadeh, A.; Roshan, S.; Goldstein, A.; Douglas, J.; Perez, R.; Li, Y.; Ewert, K. K.; Safinya, C. R.

10.1101/2025.05.24.655953 — bioengineering — Posted on 2025-05-29

542 Improving Cellular Senescence Detection with Weak Gene Markers in Single-Cell RNA-seq vi Iterative Imputation

Xu, P.; Zhang, H.; Zhu, S.; Kong, Y.

10.1101/2025.05.25.656048 — genomics — Posted on 2025-05-29

543 Robust Serum Proteomic Signatures of APOE2

Sebastiani, P.; Reed, E.; Chandler, K. B.; Lopez, P.; Lords, H.; Bae, H.; Costello, C. E.; Au, M.; Denn, L.; Li, M.; Xiang, Q.; Noh, H.; Pflieger, L.; Funk, C.; Rappaport, N.; Nygaard, M.; Short, M.; Brent, M.; Monti, S.; Andersen-Toomey, S. L.; Perls, T.

10.1101/2025.05.24.655950 — genetics — Posted on 2025-05-29

544 Refining a molecular tool kit to capture tropicalization in Mediterranean Marine Protected Areas

Neave, E. F.; Dimitriadis, C.; Shum, P.; Riesgo, A.; Mariani, S.

10.1101/2025.05.26.656120 — ecology — Posted on 2025-05-29

545 DNA Divers: volunteer-based eDNA capture for local and global marine biodiversity monitoring

Neave, E. F.; Watson, A.; Cunnington, A.; Maiello, G.; Yates, N.; Parkes, C. J.; Crouch, F.; Catherall, H. J. N.; Shum, P.; Cai, W.; Allemann, R.; Boswarva, K.; Horner, R.; Northway, W.; Bezombes, F.; Bolton, C.; Anderson, B.; Johnson, E.; Meek, S.; Smith, G.; Mariani, S.

10.1101/2025.05.26.656130 — ecology — Posted on 2025-05-29

546 Woody plant encroachment enhances negative interactions in Arctic plant communities over the last 24,000 years

Liu, Y.; Jia, W.; Liu, S.; Lisovski, S.; Stoof-Leichsenring, K. R.; Farkas, L. Z.; Herzschuh, U.

10.1101/2025.05.26.656118 — ecology — Posted on 2025-05-29

547 VAB-8/KIF26, LIN-17/Frizzled, and EFN-4/Ephrin, control distinct stages of posterior neuroblast migration downstream of the MAB-5/Hox transcription factor in Caenorhabditis elegans

Jain, V. D.; Lundquist, E. A.

10.1101/2025.05.28.656589 — developmental biology — Posted on 2025-05-29

548 Correlates of protection against African swine fever virus identified by a systems immunology approach

Lotonin, K.; Brito, F.; Mehinagic, K.; Garcia-Nicolas, O.; Liniger, M.; Donze, N.; Python, S.; Talker, S.; Ploegaert, T.; Ruggli, N.; Benarafa, C.; Summerfield, A.

10.1101/2025.05.25.655978 — immunology — Posted on 2025-05-29

549 Determinants of visual ambiguity resolution

Linde-Domingo, J.; Ortiz-Tudela, J.; Voeller, J.; Hebart, M. N.; Gonzalez-Garcia, C.

10.1101/2025.05.28.656283 — neuroscience — Posted on 2025-05-29

550 Seeing through the Static: Reduced Imagery Vividness in Aphantasia is Associated with Impaired Temporal Lobe Signal Complexity

Noble, C.; Taylor, N. L.; Milton, F.; Fulford, J.; Tan, J. B.; O'Callaghan, C.; Zeman, A.; Shine, J.

10.1101/2025.05.25.655911 — neuroscience — Posted on 2025-05-29

551 Pre-search attentional focus supports learned suppression in visual search

Zhou, Y.; Wang, L.; Li, X.; Theeuwes, J.; Wang, B.

10.1101/2025.05.29.656755 — neuroscience — Posted on 2025-05-29

552 From Synapses to Dynamics: Obtaining Function from Structure in a Connectome Constrained Model of the Head Direction Circuit

Duan, S.; Dong, L. L.; Fiete, I.

10.1101/2025.05.26.655406 — neuroscience — Posted on 2025-05-29

553 Scikit-NeuroMSI: A Generalized Framework for Modeling Multisensory Integration

Paredes, R.; Cabral, J. B.; Series, P.

10.1101/2025.05.26.656124 — neuroscience — Posted on 2025-05-29

554 The genomic and transcriptional landscape of the spinal cord H3K27-altered diffuse midline glioma suggests the potential therapeutic strategy

Xiao, Y.; Li, M.; Gao, Q.; Qian, Z.; Shang, Y.; Jing, L.; Zhen, Z.; Ai, Y.; Wang, G.; Kee, K.; Zhang, W.

10.1101/2025.05.25.655886 — cancer biology — Posted on 2025-05-29

555 Circos Plots for Genome Level Interpretation of Genomic Prediction Models

Tomura, S.; Powell, O. M.; Wilkinson, M. J.; Cooper, M.

10.1101/2025.05.25.656055 — bioinformatics — Posted on 2025-05-29

556 Functional characterization of pathogenic SATB2 missense variants identifies distinct effects on chromatin binding and transcriptional activity

den Hoed, J.; Semmekrot, F.; Verseput, J.; Dingemans, A. J.; Schijven, D.; Francks, C.; Zarate, Y. A.; Fisher, S. E.

10.1101/2025.05.28.656698 — genetics — Posted on 2025-05-29

557 PloverDB: A high-performance platform for serving biomedical knowledge graphs as standards-compliant web APIs

Glen, A. K.; Deutsch, E. W.; Ramsey, S. A.

10.1101/2025.03.09.642156 — bioinformatics — Posted on 2025-05-29

558 KcatNet: A Geometric Deep Learning Framework for Genome-Wide Prediction of Enzyme Catalytic Efficiency

Pan, T.; Cui, X.; Koh, H. Y.; Bi, Y.; Wang, X.; Zhang, Y.; Hu, S.; Webb, G. I.; Kurgan, L.; Zhang, G.; Song, J.

10.1101/2025.03.09.642294 — bioinformatics — Posted on 2025-05-29

559 sciLaMA: A Single-Cell Representation Learning Framework to Leverage Prior Knowledge from Large Language Models

Hu, H.; Zhang, S.; Choi, Y.; Malladi, V. S.; Quon, G.

10.1101/2025.01.28.635153 — bioinformatics — Posted on 2025-05-29

560 A nucleic acid prodrug that activates mitochondrial respiration, promotes stress resilience, and prolongs lifespan

Anada, T.; Kawahara, M.; Shimada, T.; Kuroda, R.; Okamura, H.; Setoyama, D.; Nagatsugi, F.; Kunisaki, Y.; Kage-Nakadai, E.; Kobayashi, S.; Tanaka, M.

10.1101/2024.11.16.623599 — bioengineering — Posted on 2025-05-29

561 Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum

Setogawa, S.; Okauchi, T.; Hu, D.; Wada, Y.; Hikishima, K.; Onoe, H.; Nishizawa, K.; Sakayori, N.; Miyawaki, H.; Kitanishi, T.; Mizuseki, K.; Cui, Y.; Kobayashi, K.

10.1101/2023.10.19.563198 — animal behavior and cognition — Posted on 2025-05-29

562 Odorant receptors mediating avoidance of toxic mustard oils in Drosophila melanogaster are expanded in herbivorous relatives

Matsunaga, T.; Reisenman, C. E.; Goldman-Huertas, B. M.; Rajshekar, S.; Suzuki, H. C.; Tadres, D.; Wong, J.; Louis, M.; Ramirez, S. R.; Whiteman, N. K.

10.1101/2024.10.08.617316 — evolutionary biology — Posted on 2025-05-29

563 Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila

Takada, Y.; Ichinose, T.; Fuse, N.; Saito, K.; Ikeda-Ohtsubo, W.; Tanimoto, H.; Hori, M.

10.1101/2024.08.22.608892 — evolutionary biology — Posted on 2025-05-29

564 Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

Deerinck, T.; Peltier, S.; Ellisman, M.

10.1101/2025.05.28.656661 — cell biology — Posted on 2025-05-29

565 SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres

Spindler, J.; Pandolfo, F.; Koch, A. E.; Piccirillo, P.; Bihler, J.; Morgenstern, M.; Coon, J.; Haensel-Hertsch, R.; Mehta, K. P. M.; Panier, S.

10.1101/2025.05.28.656696 — cell biology — Posted on 2025-05-29

566 Filopodia numbers impact chemotactic migration speed

Schroder, A. L.; Oster, L. D.; Savich, Y.; Titus, M. A.

10.1101/2025.05.28.656686 — cell biology — Posted on 2025-05-29

567 An expanded palette of bright and photostable organellar Ca2+ sensors

Moret, A.; Farrants, H.; Fan, R.; Zingg, K.; Silva, B.; Roselli, C.; Oertner, T. G.; Gee, C. E.; Hadjieconomou, D.; Rangaraju, V.; Schreiter, E. R.; de Juan-Sanz, J.

10.1101/2025.01.10.632364 — cell biology — Posted on 2025-05-29

568 Enalapril mitigates senescence and aging-related phenotypes by targeting antioxidative genes via phosphorylated Smad1/5/9

Lyu, W.; Wang, H.; Du, Z.; Wei, R.; He, J.; Meng, F.; Bi, J.; Zhang, L.; Zhang, C.; Guan, Y.; Tao, W.

10.1101/2024.11.27.625711 — cell biology — Posted on 2025-05-29

569 Evaluating the pathogenicity, stability, and stereochemical effects of variants of unknown significance in TREM2 using orthogonal structural analyses

Pillai, J.; Sung, K.; Shi, L.; Wu, C.

10.1101/2025.05.25.656054 — neuroscience — Posted on 2025-05-29

570 Perinatal fluoxetine exposure increases male rat sexual behavior

Baann, A. K.; Houwing, D. J.; Olivier, J. D. A.; Heijkoop, R.; Snoeren, E. M. S.

10.1101/2025.05.26.656113 — neuroscience — Posted on 2025-05-29

571 Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

Toyoda, H.; Kim, D.; Koh, B. G.; Sano, T.; Kanematsu, T.; oh, S. B.; Kang, Y.

10.1101/2025.03.10.642335 — neuroscience — Posted on 2025-05-29

572 Decoding the Cognitive map: Learning place cells and remapping

Pettersen, M. B.; Schoyen, V. S.; Malthe-Sorenssen, A.; Lepperod, M. E.

10.1101/2024.03.14.585049 — neuroscience — Posted on 2025-05-29

573 The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.

Calleja, v.; Henry, J. C.; Cobbaut, M.; Sewell, J.; Rizzoti, K.; Houghton, F.; Boeing, S.; Anyanwu, N.; Varsani-Brown, S.; Snoeks, T.; Suarez-Bonnet, A.; Priestnall, S. L.; McDonald, N. Q.; Cameron, A. J.; Parker, P. J.

10.1101/2025.05.28.656646 — cancer biology — Posted on 2025-05-29

574 Cortical Tension Links Curvature to Tissue Growth in the Cellular Potts Model

Fastabend, K. L.; Bidan, C. M.; Dunlop, J. W. C.; Kollmannsberger, P.

10.1101/2025.05.26.656125 — biophysics — Posted on 2025-05-28

575 Chemotaxis of branched cells in complex environments

Liu, J.; Ron, J. E.; Rinaldi, G.; Williantarra, I.; Georgantzoglou, A.; de Vries, I.; Sixt, M.; Sarris, M.; Gov, N.

10.1101/2025.05.27.656457 — biophysics — Posted on 2025-05-29

576 miR-190 is a Key Regulator in Establishing Cell Polarity and Specification in the Drosophila Nervous System

Ascencio, G.; Galvan, L.; Sanchez, J. M.; Nagainis, A.; Tam, C.; Goins, L. M.; Riggs, B.

10.1101/2025.05.28.656688 — cell biology — Posted on 2025-05-28

577 Kidney cystogenesis in embryonic- and adult-onset ADPKD is suppressed from lack of adenylyl cyclase targeting to cilia

Hwang, S.-H.; Choi, K.; Badgandi, H.; White, K.; Xun, Y.; Qian, F.; Mukhopadhyay, S.

10.1101/2025.05.27.656198 — cell biology — Posted on 2025-05-29

578 Establishment of Drosophila Intestinal Cell Lines.

Luhur, A.; Mariyappa, D.; Bohall, P.; Multini, L. C.; Elkins, M.; Zelhof, A.

10.1101/2025.05.27.656384 — cell biology — Posted on 2025-05-29

579 Kinesin drive meiotic chromosome dynamics via interaction with the KASH5-LINC complex

Ditamo, Y.; Shi, W.; Previato, L.; Gillies, J. J.; Carbajal, A.; Kinter, M.; DeSantis, M. E.; Bisig, G.; Pezza, R. J.

10.1101/2025.05.28.656678 — cell biology — Posted on 2025-05-29

580 miR-196a-5p and miR-342-3p mediate skeletal muscle and thermogenic adipose tissue crosstalk through extracellular vesicles

Tischer, D.; Schranner, D.; Kallabis, S.; Braunsperger, A.; Schoenfelder, M.; Gnad, T.; Jost, P. J.; Nesic, S.; Renziehausen, F.; Fester, L.; Buness, A.; Hasenauer, J.; Meissner, F.; Pfeifer, A.; Wackerhage, H.; Soriano-Arroquia, A.

10.1101/2025.05.28.656129 — cell biology — Posted on 2025-05-29

581 Inhibition of peroxisomal protein PRX-11 promotes longevity in Caenorhabditis elegans via enhancements to mitochondria

Flora, Y.; Shastri, D.; Bohnert, K. A.

10.1101/2025.05.28.656437 — cell biology — Posted on 2025-05-29

582 Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation

Swann, J. W.; Fung, J. H.; Chen, Z.; Olson, O. C.; Collins, A.; Lhakang, T.; Proven, M. A.; Zhang, R.; Rabadan, R.; Passegue, E.

10.1101/2025.05.28.656712 — cell biology — Posted on 2025-05-29

583 Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation

Panek, J.; Sun, C.; Kataura, T.; Fielder, E.; Booth, L.; Yue, W.; Richardson, G.; Reynisson, J.; Korolchuk, V. I.

10.1101/2025.05.27.656309 — cell biology — Posted on 2025-05-29

584 PINK1 SUMOylation regulates basal mitophagy

Ramesh, N. S.; Seager, R.; Wilkinson, K.; Henley, J. M.

10.1101/2025.05.27.656300 — cell biology — Posted on 2025-05-29

585 Expression of Lysyl Oxidase Family Enzymes During Human Endometrial Decidualization

Boniface, C.; Yu, J.; Taylor, R. N.; Bryant, B.; DeWitt, J.; Nallasamy, S.

10.1101/2025.05.28.656636 — cell biology — Posted on 2025-05-29

586 A systematic investigation of endothelial cell behavior under hydrostatic pressure

Venturini, G.; Sikligar, A.; De Campo, G.; Eddington, D.

10.1101/2025.05.27.656423 — cell biology — Posted on 2025-05-29

587 Identification of a Novel Spliced Variant of ADAMTS13 in Human Mesenchymal Stem Cells

Dutta Gupta, S.; Pramanik, N.; TA, M.

10.1101/2025.05.28.656520 — cell biology — Posted on 2025-05-29

588 Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Parham, J.; Cezanne, A.; Sorichetti, V.; Hoogenberg, B.; Foo, S.; Kuo, Y.-w.; Mawdesley, E.; Gatward, L. D.; Schulze, U.; Boulanger, J.; Saric, A.; Baum, B.

10.1101/2025.05.28.656325 — cell biology — Posted on 2025-05-29

589 Transgenerational dynamics of gut microbiota in black soldier fly larvae (Hermetia illucens) reared on a novel substrate

Silvaraju, S.; Lim, A. C. H.; Tang, Y. J.; Kittelmann, S.; Puniamoorthy, N.

10.1101/2025.05.28.656550 — microbiology — Posted on 2025-05-28

590 Convergent Skeletal Muscle Cytokine Responses to TFEB Overexpression and Voluntary Wheel Running Reflect Sex-Based Variability in Exercise Adaptations

Patterson, D. C.; Birnbaum, A.; Matthews, I.; Cortes, C. J.

10.1101/2025.05.28.655862 — physiology — Posted on 2025-05-28

591 VEGF-C-mediated Cardiac Lymphangiogenesis Promotes Inflammation Resolution in Autoimmune Acute Myocarditis in Mice

Nakanishi, N.; Nakamori, S.; Hara, S.; Nagaharu, K.; Matsuyama, R.; Fujita, S.; Okamoto, R.; Dohi, K.; Hiroe, M.; Imanaka-Yoshida, K.; Maruyama, K.

10.1101/2025.05.25.656051 — pathology — Posted on 2025-05-28

592 Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis

Edirisuriya, P.; Liyanage, P.; Lee, J.; Shetty, A. J.; Liu, H.; Hutchings, D.; Freeman, A. J.; Nathan, J. D.; Appakalai, B.; Pandol, S. J.; Jegga, A. G.; Naren, A. P.; Arora, K.

10.1101/2025.05.25.656006 — pathology — Posted on 2025-05-28

593 Hybrid Deep Learning with Protein Language Models and Dual-Path Architecture for Predicting IDP Functions

Liang, J.; Peng, Z.

10.1101/2025.05.25.655984 — bioinformatics — Posted on 2025-05-28

594 Temporal dynamics of color polymorphism and hybridization in Colias butterflies

Jahner, J. P.; Forister, M.; Parchman, T.; Burdo, S.; McFarlane, S. E.; Buerkle, C. A.; Nice, C.; Fordyce, J.; Shapiro, A.

10.1101/2025.05.25.656022 — evolutionary biology — Posted on 2025-05-28

595 Interaction of two tightly linked loci in an adaptive genomic hotspot explains exploration behavior in juvenile Atlantic salmon in freshwater.

Aykanat, T.; Erkinaro, J.

10.1101/2025.05.28.656530 — ecology — Posted on 2025-05-28

596 Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data

Fontaine, M.; Vives, M. J. D.; Saez, M.; Maizels, R.; Finnie, E.; Briscoe, J.; Rand, D. A.

10.1101/2025.05.28.656648 — developmental biology — Posted on 2025-05-28

597 Spatiotemporal dynamics of CD73 in mouse retina under physiological conditions

Ishii, R.; Sakurai, K.; Hosomi, N.; Fleischmann, B.; Mizuno, S.; Kimura, K.; Yanagisawa, H.

10.1101/2025.05.25.655881 — developmental biology — Posted on 2025-05-28

598 Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression

Ross, C. J.; Sarusi, Y.; Lubelsky, Y.; Perry, R. B.-T.; Mavashov, A.; Turk, S.; Rubinstein, M.; Ulitsky, I.

10.1101/2025.05.28.656657 — molecular biology — Posted on 2025-05-28

599 A safer fluorescent in situ hybridization protocol for cryosections

Chihara, A.; Mizuno, R.; Kagawa, N.; Takayama, A.; Okumura, A.; Suzuki, M.; Shibata, Y.; Mochii, M.; Ohuchi, H.; Sato, K.; Suzuki, K.-i. T.

10.1101/2025.05.25.655994 — molecular biology — Posted on 2025-05-28

600 Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and CGRP sensitization

Kaiser, E. A.; Cavanah, A.; Aguirre, G. K.; Jensen, F. E.

10.1101/2025.05.24.655946 — neuroscience — Posted on 2025-05-28

601 Macroscale Connectivity in the Octopus brain

Pizzulli, F.; Barjami, M.; Edelman, D. B.; Fiorito, G.; Ponte, G.

10.1101/2025.05.28.656524 — neuroscience — Posted on 2025-05-28

602 GPR88 localization to primary cilia in neurons is cell-type specific.

Guan, Y. L.; Kieffer, B.; von Zastrow, M.; Ehrlich, A. T.

10.1101/2025.05.28.656656 — neuroscience — Posted on 2025-05-28

603 SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

Statoulla, E.; Zafeiri, M.; Chalkiadaki, K.; Voudouri, G.; Gkika, K. S.; Papazoglou, C.; Durcan, T.; Khoutorsky, A.; Jafarnejad, S. M.; Maguire, S.; Dityatev, A.; Gkogkas, C. G.

10.1101/2025.05.28.656641 — neuroscience — Posted on 2025-05-28

604 Vesicular Rps6 released by astrocytes regulate local translation and enhance synaptic markers in neurons

Gamarra, M.; de la Cruz-Gambra, A.; Blanco-Urrejola, M.; Gonzalez, E.; Azkargorta, M.; Elortza, F.; Falcon-Perez, J. M.; Baleriola, J.

10.1101/2025.05.28.656644 — neuroscience — Posted on 2025-05-28

605 Neonatal White Matter Microstructure Predicts Infant Attention Disengagement from Fearful Faces

Audah, H. K.; Pulli, E. P.; Nolvi, S.; Jolly, A.; Rosberg, A.; Luotonen, S.; Wigley, I. L. C. M.; Hashempour, N.; Li, R.; Vartiainen, E.; Suuronen, I.; Haikio, T.; Merisaari, H.; Lewis, J. D.; Korja, R.; Tuulari, J. J.; Karlsson, H.; Karlsson, L.; Kataja, E.-L.

10.1101/2025.05.28.655764 — neuroscience — Posted on 2025-05-28

606 Optimized feature gains explain and predict successes and failures of human selective listening

Griffith, I. M.; Hess, R. P.; McDermott, J. H.

10.1101/2025.05.28.656682 — neuroscience — Posted on 2025-05-28

607 Continuous dynamics of cooperation and competition in social foraging

Lewen, D.; Ivanov, V.; Dehning, J.; Russ, J.; Fischer, A.; Penke, L.; Schacht, A.; Gail, A.; Priesemann, V.; Kagan, I.

10.1101/2025.05.28.655569 — neuroscience — Posted on 2025-05-28

608 Contextual inference through flexible integration of environmental features and behavioural outcomes

Passlack, J.; MacAskill, A. F.

10.1101/2025.05.28.656607 — neuroscience — Posted on 2025-05-28

609 Metabolic basis of the astrocyte-synapse interaction governs dopaminergic-motor connection

Xu, Y.; Kong, P.; Wang, M.; Mao, Y.; Ma, Z.

10.1101/2025.05.28.656515 — neuroscience — Posted on 2025-05-28

610 Dystrophin-deficiency stiffens skeletal muscle and impairs elasticity: an in vivo rheological examination

Devananthan, P.; Craven, R.; Joe, K.; Major, G. S.; Chen, J.; Kabaliuk, N.; Lindsay, A.

10.1101/2025.05.25.655634 — physiology — Posted on 2025-05-28

611 Ex vivo high-resolution nano-computed tomography imaging reveals spatial architecture of the adult male mouse lower urogenital tract

Limkar, A. R.; Sharma, S. M.; Ricke, W. A.

10.1101/2025.05.25.656031 — pathology — Posted on 2025-05-28

612 Metformin Does Not Attenuate Angiotensin II-Induced Aortic Aneurysms in Low-Density Lipoprotein Receptor Deficient Mice

Tyagi, S.; Ito, S.; Hubbuch, J.; Franklin, M.; Howatt, D.; Lu, H.; Daugherty, A.; Sawada, H.

10.1101/2025.05.25.656029 — pathology — Posted on 2025-05-28

613 House of Clocks: On the Misuse of Ageing Composite Measures

Hu, I.

10.1101/2025.05.24.655934 — bioinformatics — Posted on 2025-05-28

614 Identifying Molecular Determinants and Therapeutic Targets in Luminal B Breast Cancer: A Systems Biology Approach

Saeidi, Y.; Ghorbani, M.; Najafi, A.; Moosazadeh Moghaddam, M.

10.1101/2025.05.25.656027 — bioinformatics — Posted on 2025-05-28

615 Computational Fluid Dynamics in Highly Complex Geometries Using MPI-Parallel Lattice Boltzmann Methods: A Biomedical Engineering Application

Bozorgpour, R.

10.1101/2025.05.25.656026 — bioengineering — Posted on 2025-05-28

616 Intriguing relationship between chromosome I nuclear aneuploidy and mitochondrial intron deletion in yeast

Gargouri, A.

10.1101/2025.05.25.656015 — genetics — Posted on 2025-05-28

617 Engineering the key central metabolic enzyme to utilize a non-canonical redox cofactor

Kim, J. Y.; King, E.; Cui, Y.; Zhang, L.; Siegel, J. B.; Li, H.

10.1101/2025.05.28.656713 — molecular biology — Posted on 2025-05-28

618 Methicillin-Resistant Staphylococcus aureus has Phenotypic Variation in mecA Expression that Alters Antibiotic Sensitivity

Ma, D.; Arya, R.; Knapick, B. A.; Sadaka, N.; Rempuszewski, J.; Moul, C.; Mandell, J. B.; Shah, N. B.; Doub, J. B.; Gish, C.; Parker, D.; Sydlik, S. A.; Wood, H.; Cooper, V. S.; Richardson, A. R.; Shanks, R. M.; Urish, K. L.

10.1101/2025.05.28.656574 — microbiology — Posted on 2025-05-28

619 Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens

Ghoreyshi, Z. S.; Tubo, N.; Zammataro, L.; Mao, X.; Ngai, H.; Wang, D.; Chen, Y.; He, Q.; Cisneros, E.; Liang, S.; Koppikar, P. J.; Lin, X.; Molldrem, J. J.; George, J. T.

10.1101/2025.05.25.655924 — immunology — Posted on 2025-05-28

620 VCAN is essential for ERK5-driven tumorigenesis in soft tissue sarcoma

Jimenez Suarez, J.; Cimas, F. J.; Paricio, J. J.; Belandia, B.; Berrouayel Dahour, Y.; Arconada-Luque, E.; Matilla-Almazan, S.; Soffientini, C.; Percio, S.; Redondo-Garcia, S.; Garcia-Flores, N.; Garnes-Garcia, C.; Fernandez-Aroca, P.; Martinez-Gomez, J. J.; Fernandez-Aramburo, A.; Nam-Cha, S. H.; Rovida, E.; Pandiella, A.; Esparis-Ogando, A.; Pasquali, S.; Rodriguez-Manzaneque, J. C.; Del Peso, l.; Ruiz Hidalgo, M. j.; Sanchez-Prieto, R.

10.1101/2025.05.28.654281 — cancer biology — Posted on 2025-05-28

621 Collagen-Based Gut-on-Chip for in vitro modeling of intestinal barrier function and host-pathogen interactions

Lopez Garcia, F.; Leng, J.; de Oliveira, H.; Nassoy, P.; Dementhon, K.

10.1101/2025.05.24.655930 — bioengineering — Posted on 2025-05-28

622 The genomic legacy of selectively breeding rhesus macaques for HIV/AIDS-related research

Lyke, M. M.; Bagwell, A.; Newman, D.; Galindo, S.; Church, T.; Christensen, C.; Gray, S. B.; Cox, L. A.; Ross, C. N.; Kaushal, D.; Cheeseman, I. H.; Cole, S. A.

10.1101/2025.05.26.654976 — genomics — Posted on 2025-05-28

623 Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood

Gupta, R.; Durham, T. J.; Chau, G.; Uddin, M. M.; Lu, W.; Karczewski, K. J.; Howrigan, D.; Natarajan, P.; Zhou, W.; Neale, B. M.; Mootha, V. K.

10.1101/2025.05.25.655566 — genetics — Posted on 2025-05-28

624 Rapid adaptation and extinction across climates in synchronized outdoor evolution experiments of Arabidopsis thaliana

Wu, X.; Bellagio, T.; Peng, Y.; Czech, L.; Lin, M.; Lang, P.; Epstein, R.; Abdelaziz, M.; Alexander, J.; Caton-Darby, M.; Alonso-Blanco, C.; Andersen, H. L.; Berbel, M.; Bergelson, J.; Burghardt, L.; Delker, C.; Dimitrakopoulos, P. G.; Donohue, K.; Durka, W.; Escribano-Avila, G.; Franks, S. J.; Fritschi, F. B.; Galanidis, A.; Garcia-Fernandez, A.; Garcia-Munoz, A.; Hamann, E.; Herber, M.; Hutt, A.; Iriondo, J. M.; Juenger, T. E.; Keller, S.; Koehl, K.; Korte, A.; Korte, P.; Kuschera, A.; Lara-Romero, C.; Leventhal, L.; Maag, D.; Marcer, A.; March-Salas, M.; Meaux, J. d.; Mendez-Vigo, B.; Moren

10.1101/2025.05.28.654549 — evolutionary biology — Posted on 2025-05-28

625 Plant litter decomposition in global drylands is better predicted by precipitation seasonality and temperature than by aridity

Siebenhart, I. A.; Tognetti, P. M.; Sarquis, A.; Biancari, L.; Ballare, C.; Austin, A. T.

10.1101/2025.05.28.655532 — ecology — Posted on 2025-05-28

626 Structural Categorization and identification of electrostatic interactions in two proposed Human Serum Albumin dimerization patterns and dipyridamole interaction.

Cetinok, H.; Karakoc, V.; Ercag, E.; Sekerer, Y. M.; DeMirci, H.

10.1101/2025.05.26.656148 — molecular biology — Posted on 2025-05-28

627 Ultra-deep long-read metagenomics captures diverse taxonomic and biosynthetic potential of soil microbes

Bagci, C.; Negri, T.; Buena-Atienza, E.; Gross, C.; Ossowski, S.; Ziemert, N.

10.1101/2025.05.28.656579 — microbiology — Posted on 2025-05-28

628 Proton motive force as a driver of persister sensitization by adenosine

Thompson, N. T.; Kitzenberg, D. A.; Dowdell, A. S.; Roer, R. L.; Lee, J. S.; Worledge, C. S.; Colgan, S. P.; Kao, D. J.

10.1101/2025.05.28.655832 — microbiology — Posted on 2025-05-28

629 Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reduce Pseudomonas- biofilm formation and inflammation in CF Bronchial Epithelial Cells

Sarkar, S.; Barnaby, R.; Nymon, A.; Charpentier, L. A.; Taub, L.; Wargo, M. J.; Weiss, D. J.; Bonfield, T. L.; Stanton, B. A.

10.1101/2025.05.28.656674 — microbiology — Posted on 2025-05-28

630 Enzymatically active exudates from Alteromonas facilitate Prochlorococcus survival in stationary phase

Lu, Z.; Plummer, S.; Kizziah, J.; Biller, S.; Morris, J. J.

10.1101/2025.05.28.656624 — microbiology — Posted on 2025-05-28

631 Nutrient requirements for cell differentiation progression in Batrachochytrium dendrobatidis

Okada, N. C.; Williams-Carter, T.; Contreras, J.; Hill, T.; O'Brien, D.; Abel-Santos, E.

10.1101/2025.05.28.656562 — microbiology — Posted on 2025-05-28

632 CRISPRi-based functional genomic screening identifies genes essential for CH4-dependent growth in the methanotroph Methylococcus capsulatus Bath.

Henard, J. M.; Lee, S. A.; Yu, Y. C.; Shao, D.; Azad, R.; Henard, C. A.

10.1101/2025.05.28.656465 — microbiology — Posted on 2025-05-28

633 Induced Droplet Ovalisation (IDO): Image-based microfluidic method for high-throughput and label-free characterization of microbial proteolytic strains from wastewater sludge.

Potenza, L.; Kaminski, T. S.; Andrzejewski, M.

10.1101/2025.05.28.656601 — microbiology — Posted on 2025-05-28

634 Comprehensive evaluation of the antimicrobial properties of platelet-rich fibrin in vitro in the context of the oral microbiome and bacterial species diversity

Popowski, W.; Domanowska, D.; Koseski, D.; Ostrowski, R.; Zalewska, M.; Małecka-Giełdowska, M.; Łasica, A.; Popowska, M.

10.1101/2025.05.28.656546 — microbiology — Posted on 2025-05-28

635 Defining the importance of the arginine loop region of protegrin-1 for antimicrobial activity towards colistin-resistant Klebsiella pneumoniae.

DeBarro, C. M.; Assent, S.; Makhecha, H.; Radde, N.; Krishnan, R.; Randall, J.; de la Fuente-Nunez, C.; Fleeman, R.

10.1101/2025.05.28.656599 — microbiology — Posted on 2025-05-28

636 Resistance to heavy metals and genome sequencing of ESBL-producing and non-ESBL-producing Escherichia coli

Wenyi, M.; Tianshuai, Y.; yu, D.; Yue, X.; saihui, S.; Han, S.; YiFei, Y.; hua, j.

10.1101/2025.05.28.656662 — microbiology — Posted on 2025-05-28

637 Microbial community composition explains wintertime greenhouse gas fluxes in an oroarctic tundra ecosystem

Viitamäki, S.; Eronen-Rasimus, E.; Virkkala, A.-M.; Marushchak, M.; Biasi, C.; Majamäki, R.; Pessi, I. S.; Hultman, J.

10.1101/2025.05.28.656102 — microbiology — Posted on 2025-05-28

638 The G57 genotype of the BJ/94-like H9N2 lineage exhibits increased replication and virulence in chickens compared to the G1 Middle East Group B lineage

Bhat, S.; Sadeyen, J.-R.; Yang, J.; Chrzastek, K.; Karunarathna, T.; Qureshi, M.; Bialy, D.; Shelton, H.; Iqbal, M.

10.1101/2025.05.28.656345 — microbiology — Posted on 2025-05-28

639 Kasugamycin inhibits melanoma lung metastasis and regulates CHI3L1-driven M2-like tumor-associated macrophage differentiation

Sadanaga, T.; Jeong, H.-S.; Cortez, R.; Lee, J. H.; Kamle, S.; Ma, B.; Shin, S. J.; Elias, J. A.; Lee, C. G.

10.1101/2025.05.26.654629 — immunology — Posted on 2025-05-28

640 Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks

Watanabe, K.; Yamamoto, H.; Sumi, T.; Murota, H.; Osaki, H.; Kawamoto, K.; Matsui, T.; Masamizu, Y.; Sato, S.; Hirano-Iwata, A.

10.1101/2025.05.25.654991 — neuroscience — Posted on 2025-05-28

641 Reconstruction of Postures Using Partial Body Information Through a Self-supervised Transformer in Mice

Ko, C.; Kim, D.

10.1101/2025.05.27.655252 — neuroscience — Posted on 2025-05-28

642 Highly reproduceable tapered fiber optoacoustic emitters by in-situ photothermal curing of PDMS for single neuron stimulation

Chen, G.; Marar, M.; Xu, Z.; Cheng, W. Y.; Yu, F.; Marar, C.; Cheng, J.-X.; Yang, C.

10.1101/2025.05.24.655947 — neuroscience — Posted on 2025-05-28

643 SIMBA-GNN: Simulation-augmented Microbiome Abundance Graph Neural Network

Parsa, M. S.; Aminian-Dehkordi, J.; Mofrad, M.

10.1101/2025.05.27.656377 — systems biology — Posted on 2025-05-28

644 Characterization of recombinase-based genetic parts and circuits using nanopore sequencing

Greco, F. V.; Cameron, S. K.; Joshi, S. H.-N.; Guiziou, S.; Brophy, J. A. N.; Grierson, C. S.; Gorochowski, T. E.

10.1101/2025.05.27.656450 — synthetic biology — Posted on 2025-05-28

645 Developing a versatile technology for agroinfiltration in multiple plants

Du, H.; Wang, T.; Ge, J.; Qu, C.; Chen, H.; Li, J.; Wang, S.; Guan, X.; Chen, T.; Si, Z.; Hu, K.; Ding, X.; Liu, L.; Zhang, J.; Mishin, A. S.; Yampolsky, I. V.

10.1101/2025.05.25.656011 — plant biology — Posted on 2025-05-28

646 A non-rectifying potassium channel increases cassava drought tolerance and storage root yield

Zierer, W.; Fritzler, M.; Chiu, T. J.; Anjanappa, R. B.; Chang, S.-H.; Metzner, R.; Quiros, J.; Lamm, C. E.; Thieme, M.; Koller, R.; Huber, G.; Muller, O.; Rascher, U.; Sonnewald, U.; Neuhaus, H. E.; Gruissem, W.; Bellin, L.

10.1101/2025.05.26.655271 — plant biology — Posted on 2025-05-28

647 Validation of a high-throughput screening assay for the characterization of cryoprotective agent toxicity

Jaskiewicz, J. J.; Callahan-Muller, A.; Gaby-Biegel, N.; Glover, Z.; Sandlin, R.

10.1101/2025.05.26.654916 — pharmacology and toxicology — Posted on 2025-05-28

648 Multiple FGFR1 mutations modulate tumorigenic mechanisms in glioneuronal tumors.

Boni, J.; Fernandez-Gonzalez, M.; Han, H.; Roca, C.; Wong, C. J.; Rioja, C.; Nogue, C.; Manen-Freixa, L.; Boulais, J.; Torres-Urtizberea, E.; Gomez, A.; Hasselblatt, M.; Estrada-Tejedor, R.; Antolin, A. A.; Elkholi, I. E.; Jabado, N.; Cote, J.-F.; Gingras, A.-C.; Rivera, B.

10.1101/2025.05.27.654799 — cancer biology — Posted on 2025-05-28

649 The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer

Gladstein, A. C.; Poltorack, C. D.; Solomon, A. M. C.; Venkatesh, S.; Adler, K. M.; Robertson, M. R.; Stransky, S.; Irizarry-Negron, V. M.; Ruiz, D. A.; Freeburg, N. F.; Sidoli, S.; Asangani, I. A.; Shaffer, S. M.; Feldser, D. M.

10.1101/2025.05.25.655971 — cancer biology — Posted on 2025-05-28

650 Decoupled Information Theoretic Feature Selection for Rapid Protein Key Tuning Residue Identification

Saeed, H.; Huang, W.; Yang, A.

10.1101/2025.05.28.653817 — bioinformatics — Posted on 2025-05-28

651 Comparative assessment of co-folding methods for molecular glue ternary structure prediction

Liao, Y.; Zhu, J.; Xie, J.; Lai, L.; Pei, J.

10.1101/2025.05.25.655997 — bioinformatics — Posted on 2025-05-28

652 Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Singh, S.; Patel, S. K.; Matsuura, R.; Velazquez, D.; Sun, Z.; Noel, S.; Rabb, H.; Fan, J.

10.1101/2025.05.25.654911 — bioinformatics — Posted on 2025-05-28

653 Ketone Bodies-mediated Cysteine Modifications Discovered by Chemical Proteomics

Zhou, Y.-F.; Zhang, L.; Niu, Z. L.; WANG, X.; Hunt, R.; Zhao, Y.; Sharifi, N.; Wang, Z. A.

10.1101/2025.05.25.655943 — biochemistry — Posted on 2025-05-28

654 Differential expression of mitochondria-associated genes in clinical samples of Plasmodium falciparum showing severe manifestations

Gujarati, S.; Gupta, D.; Kochar, S. K.; Kochar, D. K.; Das, A.

10.1101/2025.05.24.655897 — genomics — Posted on 2025-05-28

655 Local adaptation in climate tolerance at a small geographic scale contrasts with broad latitudinal patterns

Walter, G. M.; Chakraborty, A.; Cockerell, F.; Kellermann, V.; Alton, L. A.; White, C. R.; Hall, M. D.; Sgro, C. M.

10.1101/2025.05.27.655235 — evolutionary biology — Posted on 2025-05-28

656 Multi-stage single-cell atlas of Botryllus schlosseri asexual development unveils dedifferentiating bud founder cells

Lebel, M.; Sancerini, T.; Rabiteau, S.; Marchal, S.; Sharma, P.; Scully, T. D.; Balissat, E.; Hiebert, L. S.; De Tomaso, A. W.; Klein, A. M.; Alie, A.; Tiozzo, S.

10.1101/2025.05.27.655565 — developmental biology — Posted on 2025-05-28

657 Double strand breaks drive toxicity in Huntington's disease mice with or without somatic expansion.

Polyzos, A. A.; Yoo, J. H.; Cheong, A.; Blagec, L.; Nagel, Z. D.; McMurray, C. T.

10.1101/2025.05.27.654663 — molecular biology — Posted on 2025-05-28

658 Aptamer-Enabled Discovery and Clinical Analysis of Exosomal Surface Biomarkers in Hepatocellular Carcinoma

Cao, H.; Xu, D.; Su, Y.; Zhang, C.; Bian, S.; Yan, X.; Li, S.; Xuan, H.; Long, J.; Yao, P.; Liu, X.; Cheng, X.; Su, H.; Chen, Y.; Li, Y.; Li, J.; Shi, W.; Wang, K.; Xing, B.; Zhang, L.

10.1101/2025.05.28.655095 — molecular biology — Posted on 2025-05-28

659 Human genetic variation shapes the response of neurons to interferons

Andzelm, M. M.; Bolshakova, S.; Pettinari, N.; Tegtmeyer, M.; Meyer, D.; Johnson, A.; Mello, C. J.; Yu, C. T.; Mazureac, I.; Genovese, G.; Maglieri, A.; Ichihara, K.; Hogan, M.; Hawes, D.; McCarroll, S. A.; Nehme, R.

10.1101/2025.05.28.653507 — molecular biology — Posted on 2025-05-28

660 Fish from the sky: Airborne eDNA tracks aquatic life

Ip, A. Y. C.; Guri, G.; Allan, E. A.; Kelly, R. P.

10.1101/2025.05.25.655195 — molecular biology — Posted on 2025-05-28

661 Genome-Wide Interrogation of SARS-CoV-2 RNA-Protein Interactions Uncovers Hidden Regulatory Sites

Xiang, J. S.; Zhao, K. X.; Tadri, L.; Tamaru, K.; Yee, B. A.; Rothamel, K.; Schmok, J. C.; Mueller, J. R.; Park, S. S.; Madrigal, A. A.; McVicar, R. N.; Kwong, E. M.; Croker, B. A.; Clark, A. E.; Carlin, A. F.; Acevedo, C.; McCole, D. F.; O'Leary, S. E.; Hai, R.; Leibel, S. L.; Yeo, G. W.

10.1101/2025.05.26.656146 — molecular biology — Posted on 2025-05-28

662 FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis

Sasaki, M.; Wang, J.; Zhou, Y.; Kennedy, Z. V.; Teranishi, R.; Itami, T.; Ishikawa, S.; Winters, H. E.; Hara, T.; McMillan, E.; Mahon, M.; Golden, H.; Dhakal, D.; Bacarella, A.; Umeweni, C.; Wilkins, B. J.; Karakasheva, T. K.; Whelan, K. A.; Shaffer, S. M.; Ruffner, M. A.; Muir, A.

10.1101/2025.05.25.655133 — molecular biology — Posted on 2025-05-28

663 Structural modelling and dynamics of the full-length Homer1 multimer

Kalman, Z. E.; Czajlik, A.; Maruzs, B.; Farkas, F.; Pap, I.; Homonnay, C.; Klumpler, T.; Batta, G.; Gaspari, Z.; Peterfia, B.

10.1101/2025.05.26.655084 — molecular biology — Posted on 2025-05-28

664 Five-year (2017-2022) evolutionary dynamics of human coronavirus OC43 in southern France based on whole genome next-generation sequencing

Houmadi, H.; Boschi, C.; Le Targa, L.; Py, J.; LAGIER, J.-C.; LESAGE, L.; MORAND, A.; La Scola, B.; Colson, P.

10.1101/2025.05.26.656003 — microbiology — Posted on 2025-05-28

665 Design of a Streptolysin O Epitope-Centric Nanoparticle Vaccine Against Streptococcus pyogenes

Tang, D.; Chao, Y.; Hjortswang, E.; Ströbaek, J.; Hultgren, L.; Mohanty, T.; Karlsson, C.; Ekström, S.; Happonen, L.; Shannon, O.; Malmström, L.; Malmström, J.

10.1101/2025.05.25.655993 — immunology — Posted on 2025-05-28

666 MitoTracker transfers from astrocytes to neurons independently of mitochondria

Hole, K. L.; Norkett, R.; Russell, E.; Strom, M.; Howden, J. H.; Corbett, N. J.; Brownlees, J.; Devine, M. J.

10.1101/2025.05.27.655523 — neuroscience — Posted on 2025-05-28

667 Topoisomerase Based Control of Cellular Transcription and Growth

Clark, H. K.; Yeung, E.; Thirumaligai, R.; Giusto, C.

10.1101/2025.05.26.655193 — systems biology — Posted on 2025-05-28

668 FMO and CYP monooxygenase families determine the metabolic flux of hydroxylated tryptamine derivatives in barley (Hordum vulgare) following pathogen infection

Christensen, J. M.; Toldam-Andersen, M. M.; Jorgensen, H. J.; Micic, N.; Bjarnholt, N.; Vijayanathan, M.; Motawie, M. S.; Pizaine, M.; Günther, J.; Kjaerulff, L.; Staerk, D.; Burow, M.; Thodberg, S.; Neilson, E. H.

10.1101/2025.05.25.656007 — plant biology — Posted on 2025-05-28

669 Repurposing statins in combination therapy for effective ablation of metastatic breast cancer

Aara, R.; Sinai Borker, N.; Sajimon, J.; Subhadarshini, S.; VP, S.; Nimbalkar, V.; Moorthy, M.; P Thankamony, A.; Krishnan R, A.; Aich, D.; Das, D.; Jolly, M. K.; Prabhu, J. S.; Nair, R.

10.1101/2025.05.25.655937 — cancer biology — Posted on 2025-05-28

670 When does additional information improve accuracy of RNA secondary structure prediction?

Rose, L.; Giraldo, L. S.; Nguyen, D. D.; Wheeler, M.; Murrugarra, D.

10.1101/2025.03.18.643972 — bioinformatics — Posted on 2025-05-28

671 GLMMcosinor: Flexible Cosinor Modeling to Characterize Rhythmic Time Series Using a Generalized Linear Mixed Modeling Framework

Parsons, R.; Jayasinghe, O.; White, N. M.; Chunduri, P.; Rawashdeh, O.

10.1101/2024.04.10.588934 — bioinformatics — Posted on 2025-05-28

672 LlamaAffinity: A Predictive Antibody Antigen Binding Model Integrating Antibody Sequences with Llama3 Backbone Architecture

Hossain, D.; Saghapour, E.; Song, K. M.; Chen, J. Y.

10.1101/2025.05.28.653051 — bioinformatics — Posted on 2025-05-28

673 A high-throughput assay for the measurement of Ca2+-oscillations and insulin release from uniformly sized β-cell spheroids.

Davidson, P.; Robben, S.; Rodrigues Ribeiro, R. S.; Voets, T.

10.1101/2025.05.25.655695 — bioengineering — Posted on 2025-05-28

674 Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach

Di Marco, C.; Romano, F.; Lopresti, F.; Campora, S.; Comelli, A.; Di Gesu, R.; La Carrubba, V.

10.1101/2025.05.25.655996 — bioengineering — Posted on 2025-05-28

675 Human Skin Model from 15 GHz to 110 GHz

Christ, A.; Aeschbacher, A.; Tarigan, B.; Chitnis, N.; Fallahi, A.; Kuehn, S.; Capstick, M.; Kuster, N.

10.1101/2025.05.26.652827 — bioengineering — Posted on 2025-05-28

676 Analysis of Post-Translational Modifications in the Urinary Proteome of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

Su, Y.; Gao, Y.

10.1101/2025.05.25.655980 — biochemistry — Posted on 2025-05-28

677 TIP-seq: A Single-cell Multiomics Approach for Simultaneous Transcriptome and Intracellular Protein Profiling

Xue, Y.; Qi, J.; Xie, G.; Wang, M.; Xu, W.; Ma, C.; Xu, X.; Yang, Y.; He, Y.; Guo, Y.; Chen, S.; Chen, Z.; Qiu, M.; Feng, C.; Liu, J.; Wu, H.; Liu, Y.; Xu, T.; Cao, X.

10.1101/2025.05.26.653374 — biochemistry — Posted on 2025-05-28

678 Modeling the length distribution of gene conversion tracts in humans from the UK Biobank sequence data

Masaki, N.; Browning, S. R.

10.1101/2024.12.30.630818 — genetics — Posted on 2025-05-28

679 Mechanisms of host exploitation by a microsporidian parasite

Silva, L. M.; Vallat, A.; Koella, J. C.

10.1101/2024.12.13.628237 — evolutionary biology — Posted on 2025-05-28

680 Modeling 2D Spatio-Tactile Population Receptive Fields of the Fingertip in Human Primary Somatosensory Cortex

Stoll, S.; Luesebrink, F.; Schwarzkopf, D. S.; Mattern, H.; Liu, P.; Noelle, J.; Kuehn, E.

10.1101/2025.05.24.655840 — neuroscience — Posted on 2025-05-28

681 Chronic Pb2+ Exposure Causes Hippocampal Network Hypersynchrony, Absence Seizures, and Sensorimotor Deficits

Schultheiss, N. W.; McGlothan, J. L.; Guilarte, T. R.; Allen, T. A.

10.1101/2020.06.30.181149 — neuroscience — Posted on 2025-05-28

682 Hair cell population integrity necessary to preserve vestibular function

Schenberg, L.; Simon, F.; Palou, A.; Dijan, C.; Tagliabue, M.; Llorens, J.; Beraneck, M.

10.1101/2025.03.19.644154 — neuroscience — Posted on 2025-05-28

683 Island-wide population genomic analysis of the coastal shrub, beach naupaka (Scaevola taccada L.), on Oahu

McAssey, E. V.; Downs, C.; Heyduk, K.

10.1101/2025.05.25.655311 — plant biology — Posted on 2025-05-28

684 Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiency

Miyata, K.; Yang, L.; Yang, Y.; Kumegawa, K.; Maruyama, R.

10.1101/2025.05.24.655549 — cancer biology — Posted on 2025-05-28

685 Role of DEPDC1 in Glioblastoma Malignant Phenotype and Radiosensitivity

Yu, Y.; Deng, H.; Song, P.; Liu, Y.; Qiu, Q.; Zhang, M.

10.1101/2025.05.25.655961 — cancer biology — Posted on 2025-05-28

686 Helfrich Monte Carlo Flexible Fitting: physics-based, data-driven cell-scale simulations

Maurer, V. J.; Siggel, M.; Jensen, R. K.; Mahamid, J.; Kosinski, J.; Pezeshkian, W.

10.1101/2025.05.24.655915 — biophysics — Posted on 2025-05-28

687 Quantification of small molecule partitioning in a biomolecular condensate with 2D NMR spectroscopy

Buhl, J. M.; Mahapatra, S.; Kjaergaard, M.; Mulder, F. A. A.

10.1101/2025.05.25.656010 — biophysics — Posted on 2025-05-28

688 Molecular mechanisms of GSK3β-driven modulation of ABLIM1 and titin interactions in cardiac muscle

Sun, B.; Loftus, A.; Beh Goh Beh, B.; Hepburn, A.; Kirk, J. A.; Kekenes-Huskey, P.

10.1101/2024.12.07.627363 — biophysics — Posted on 2025-05-28

689 A breast Duct-on-Chip model for emulating invasive ductal carcinoma and testing therapies

Jouybar, M.; de Toonder, J. M. J.

10.1101/2025.05.24.655087 — bioengineering — Posted on 2025-05-28

690 Intervertebral disc impairments in a mouse model of Alzheimer's Disease

Gonzalez, C. C.; Schurman, C. A.; Wilson, K. A.; Schilling, B.; Ellerby, L. M.; Tang, S. Y.

10.1101/2025.05.24.655931 — bioengineering — Posted on 2025-05-28

691 PEDOT:PSS Microparticles for Extrudable and Bioencapsulating Conducting Granular Hydrogel Bioelectronics

Goestenkors, A. P.; Yu, J. S.; Park, J.; Wu, Y.; Espinoza, C. J. V.; Friedman, L. C.; Okafor, S. S.; Liu, T.; Chatterjee, S.; Debnath, A.; Semar, B. A.; O'Hare, C. P.; Alvarez, R. M.; Singamaneni, S.; Raman, B.; Rutz, A. L.

10.1101/2025.05.25.655149 — bioengineering — Posted on 2025-05-28

692 Chemical capture of diazo metabolites reveals biosynthetic hydrazone oxidation

Pfeifer, K.; Van Cura, D.; Wu, K. J. Y.; Balskus, E. P.

10.1101/2025.05.24.655970 — biochemistry — Posted on 2025-05-28

693 Chemosensory Adaptations in Caenorhabditis Males during the Establishment of Androdioecy.

Kannan, H.; Chow, K. L.

10.1101/2025.05.24.655903 — evolutionary biology — Posted on 2025-05-28

694 Host specificity of fungal functional groups covaries with elevation: implications for intraspecific plant interactions

Neat, A. S.; Albornoz, F.; Gervers, K. A.; Busby, P. E.; Jones, F. A.

10.1101/2025.05.24.655939 — ecology — Posted on 2025-05-28

695 Proximity and current alignment drives fertilisation success in a broadcast-spawning coral

Ricardo, G. F.; Doropoulos, C.; Humanes, A.; Lachs, L.; Martinez, H. M.; Sartori, G.; Chang, T. K. T.; Chui, A. P. Y.; Wong, E. L. C.; Stevens, J. R.; Popovic, I.; Guest, J. R.; Buccheri, E.; Idip, D.; Mumby, P. J.

10.1101/2025.05.24.654664 — ecology — Posted on 2025-05-28

696 Reconstitution of adrenocortical functional zonation from human pluripotent stem cells

Mayama, M.; Whelan, E. C.; Sato, T.; Stouffer, D. G.; Leu, N. A.; Strauss, J. F.; Auchus, R.; Sasaki, K.

10.1101/2025.05.24.655925 — developmental biology — Posted on 2025-05-28

697 Adaptive-like NK cell responses to influenza correlate with humoral immunity and are influenced by age and sex

Alves, E.; Oakes, J. M.; Simmons, J. D.; Currenti, J.; Coudert, J. D.; Foley, B.; Eason, J.; Halasa, N. B.; Talbot, H. K.; Castilho, J. L.; Mallal, S.; Gaudieri, S.; Kalams, S. A.

10.1101/2025.05.24.655902 — immunology — Posted on 2025-05-28

698 Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

Thompson, J.; Li, Y.; Song, Y.; Kim, K.-W.; Malik, A.; Xu, J.

10.1101/2025.05.25.655979 — immunology — Posted on 2025-05-28

699 Unbiased Quantification of Persistent Postural and Motor Deficits Following Spinal Cord Injury in Mice

Jobbins, S. S.; Pande, V.; Zeng, C.-W.; Poldsam, H.; Pool, A.-H.; Zhang, C.-L.; Lai, H. C.

10.1101/2025.05.24.655880 — neuroscience — Posted on 2025-05-28

700 The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot

Marinescu, A.-M.; Kamal, E.; Leary, P.; Navarro I Batista, K.; Klug, M.; Savic, N.; Le Foll, C.; Labouesse, M. A.

10.1101/2025.05.24.655907 — neuroscience — Posted on 2025-05-28

701 Evaluation of visual performance for RCS rats: A tailor-made OMR setup via DeepLabCut and PsychoPy with a customized algorithm

Wang, J.; Rueland, T.; Krause, S.; Schoeneck, M.; Shah, N. J.; Mueller, F.; Kampa, B.; Langen, K.-J.; Willuweit, A.

10.1101/2025.05.24.655932 — neuroscience — Posted on 2025-05-28

702 Energy Constraints and Neural Strategy Transitions in Alzheimer's: A Game-Theoretic Model

Kareva, I.; Karev, G.

10.1101/2025.05.24.655918 — neuroscience — Posted on 2025-05-28

703 ROMO1 loss in cholinergic neurons induces mitochondrial ultrastructural damage and ALS-like neuromuscular degeneration

Nie, W.; Jing, Z.; Cheng, L.; Li, L.; Xu, F.; Lin, L.; Dong, X.; Han, H.; Cheng, H.; Wang, X.

10.1101/2025.05.24.655877 — neuroscience — Posted on 2025-05-28

704 The visual encoding of familiar and unfamiliar tools

Valio, L.; Cuomo, M.; Ilardi, C. R.; Federico, G.

10.1101/2025.05.24.655951 — neuroscience — Posted on 2025-05-28

705 Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease

Shi, L.; Uzuni, A.; Wang, X. K.; Pressler, M.; Harle, D. W.; Chakrabarti, S.; Macedo, R.; Belay, K.; Gordillo, C. A.; Raps, E.; Zhang, J. Y. A.; Nazaret, A.; Fan, J. L.; Jin, Y.; Shen, X.; Fuller, J. S.; Azad, T.; Huang, J.; Chainani, P.; Abrams, J. A.; Del Portillo, A.; Mapara, M. Y.; Alhamar, M.; Sykes, M.; McFaline-Figueroa, J.; Azizi, E.; Reshef, R.

10.1101/2025.05.24.655962 — systems biology — Posted on 2025-05-28

706 Under salt stress quinoa stomatal guard cells control transpiration in an ABA-primed manner

Huang, S.; Messerer, M.; Muller, H. M.; Scherzer, S.; Roelfsema, M. R. G.; Weiste, C.; Krischke, M.; Korte, P.; Moog, M. W.; Mayer, K. F. X.; Ache, P.; Hedrich, R.

10.1101/2025.05.24.655927 — plant biology — Posted on 2025-05-28

707 Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesisvia Substrate Channeling

Wang, D.; Gottinger, A.; Jeong, J.; Nicoll, C. R.; Liu, J.; Kadav, T.; Cecchini, D.; Malatesta, M.; Heck, A. J. R.; Mattevi, A.; Shakhnovich, E.

10.1101/2025.05.24.655883 — biophysics — Posted on 2025-05-28

708 Quantitative Signatures of Disassembly Mechanisms Modulating Filament and Bundle Assembly in a Shared Pool

Momin, M. S. A.; Mohapatra, L.

10.1101/2025.05.24.655867 — biophysics — Posted on 2025-05-28

709 Acoustic individual identification in a species of field cricket using deep learning

Kabuga, E.; Nandi, D.; Burrell, S.; Dlamini, G.; Balakrishnan, R.; Bah, B.; Durbach, I.

10.1101/2025.05.24.655958 — bioinformatics — Posted on 2025-05-28

710 Multi-scale early warning system for influenza A spillovers

Alfonsi, T.; Bernasconi, A.; Chiara, M.; Ceri, S.

10.1101/2025.05.24.655955 — bioinformatics — Posted on 2025-05-28

711 pLM-SAV: A Δ-Embedding Approach for Predicting Pathogenic Single Amino Acid Variants

Gereben, O.; Tordai, H.; Khamisi, L.; Hegedus, T.

10.1101/2025.05.24.655916 — bioinformatics — Posted on 2025-05-28

712 Characterizing antibodies binding to the same epitope reveals limited contribution by heavy chain CDR3 sequences relative to other CDRs

Mahita, J.; Kim, H.; De Almeida Mendes, M.; Richardson, E.; Greenbaum, J. A.; Sette, A.; Nielsen, M.; Peters, B.

10.1101/2025.05.24.655967 — bioinformatics — Posted on 2025-05-28

713 Deconvolution of multiplexed peptidoform mass spectra enables high-resolution profiling of complex protein modification patterns

Cheng, Z.; Zhai, L.; Yu, L.; Chen, K.; Zhao, W.; Tan, M.; Fu, Y.

10.1101/2025.05.24.655917 — bioinformatics — Posted on 2025-05-28

714 Development of Second-Generation Acyl Silane Photoaffinity Probes for Cellular Chemoproteomic Profiling

Page, A. C. S.; Orr, L. M.; Meyers, M. L.; Belcher, B. P.; Coffey, T. G.; Scholz, S. O.; Cismoski, S.; Nomura, D.; Toste, F. D.

10.1101/2025.05.24.655972 — biochemistry — Posted on 2025-05-28

715 Younger is Better But Only for Males: Social Behavioral Development Following Juvenile Traumatic Brain Injury to the Prefrontal Cortex

Shonka, S.; Hylin, M. J.

10.1101/2025.05.24.655898 — animal behavior and cognition — Posted on 2025-05-28

716 The Genomic Basis of Social Parasitism: A Geographical Mosaic of Behavioural, Chemical, and Environmental Adaptations in a Widespread Host-Parasite System

Macit, M. N.; Collin, E.; Nieto-Blazquez, M. E.; Kever, M.; Litto, M.; Jaitner, E.; Pfenninger, M.; Feldmeyer, B.; Foitzik, S.

10.1101/2025.05.24.655926 — evolutionary biology — Posted on 2025-05-28

717 Global metabolic reprogramming and sex-specific impact of caloric restriction in a mouse model of Alzheimer's disease

Vatashchuk, M. V.; Hurza, V. V.; Bayliak, M. M.; Gospodaryov, D. V.; Lushchak, V. I.; Garaschuk, O.

10.1101/2025.05.24.655912 — neuroscience — Posted on 2025-05-28

718 How memory and adaptation cost shape cell phenotypic dynamics in response to fluctuating environments

Jain, P.; Jolly, M. K.; George, J. T.

10.1101/2025.05.24.655868 — systems biology — Posted on 2025-05-28

719 Sex Disparities in Gastric Cancer Tumor Mutation Burden and Gene Mutation Patterns

Klein, N.; Shweiki, D.

10.1101/2025.05.24.655976 — cancer biology — Posted on 2025-05-28

720 Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profiling

Kalari, K. R.; Kandimalla, K. K.; Thompson, K.

10.1101/2025.03.03.640886 — bioinformatics — Posted on 2025-05-28

721 Inference of marker genes of subtle cell state changes via iterative logistic regression

Liu, Y.; Baugh, A.; Roussos Torres, E. T.; MacLean, A. L.

10.1101/2025.05.23.655858 — bioinformatics — Posted on 2025-05-28

722 Extracellular Matrix Alterations in Chronic Ischemic Cardiomyopathy Revealed by Quantitative Proteomics

Buck, K. M.; Rogers, H. T.; Gregorich, Z. R.; Mann, M. W.; Aballo, T. J.; Gao, Z.; Chapman, E. A.; Perciaccante, A. J.; Price, S. J.; Lei, I.; Tang, P. C.; Ge, Y.

10.1101/2025.05.23.655833 — biochemistry — Posted on 2025-05-28

723 Drought reduces formation, but enhances persistence, of mineral-associated organic matter in a grassland soil

Sokol, N.; Foley, M.; Blazewicz, S. J.; Didonato, N.; Estera-Molina, K.; Firestone, M. K.; Greenlon, A.; Hungate, B. A.; Kew, W.; Pasa-Tolic, L.; Slessarev, E.; Pett-Ridge, J.

10.1101/2025.05.23.655838 — ecology — Posted on 2025-05-28

724 Computational characterization of metacognitive ability in subjective decision-making

Plate, C. R.; Govil, D.; Zheng, C. Y.; Boundy-Singer, Z. M.; Ziemba, C. M.; Lopez-Guzman, S.

10.1101/2025.05.23.655775 — neuroscience — Posted on 2025-05-28

725 Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Choy, J.; Charara, S.; Cauwenberghs, K.; McKaughan, Q.; Kim, K.-Y.; Ellisman, M.; Su, C.-Y.

10.1101/2025.02.06.636916 — neuroscience — Posted on 2025-05-28

726 Event-Related Spatio-Spectral Perturbation (ERSSP): A Scalp-Wide EEG Analysis Framework for Capturing Extralemniscal Thalamocortical Activity, Validated Using a Fragile X Syndrome Model

Kim, H.; Ethridge, L.; DeStefano, L.; Schmitt, L.; Pedapati, E.; Erickson, C.; Miyakoshi, M.

10.1101/2025.05.23.655841 — neuroscience — Posted on 2025-05-28

727 Insights from modern & historical genomes of Neorhizobium vitis, a new pathogen causing neoplastic growths on grapevine.

Wu, X.; Xi, H.; Ryder, M.; Searle, I. R.

10.1101/2025.05.23.655691 — plant biology — Posted on 2025-05-28

728 A Cellular Basis for Heightened Gut Sensitivity in Females

Venkataraman, A.; Figueroa, E. E.; Castro, J.; Navarro, F. M. C.; Soota, D.; Brierley, S. M.; Julius, D.; Ingraham, H. A.

10.1101/2025.05.23.654927 — physiology — Posted on 2025-05-28

729 A benchtop bioreactor to impart coarctation-induced deformation and assess mechanisms of endothelial dysfunction

Schock, D. J.; Armstrong, A.; Alli, A. A.; LaDisa, J. F.

10.1101/2025.05.23.655865 — physiology — Posted on 2025-05-28

730 Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer

Parikainen, M.; Suwal, U.; Rappu, P.; Heino, J.; Sahlgren, C. M.

10.1101/2025.05.23.655829 — cancer biology — Posted on 2025-05-28

731 Population-specific bycatch risks in two vulnerable anadromous clupeids: insights from otolith microchemistry

Nachon, D. J.; Pico-Calvo, A.; Daverat, F.; Vieira-Lanero, R.; Crujeiras, R. M.; Belo, A. F.; Mateus, C. S.; Quintella, B.; Almeida, P. R.; Antunes, C.; Bareille, G.; Pecheyran, C.; Claverie, F.; Lambert, P.; Lasalle, G.; Cobo, F.

10.1101/2025.05.23.655712 — ecology — Posted on 2025-05-28

732 Stressed Avoider rats show blunted sensitivity to alcohol's aversive effects: Potential contributions of the lateral habenula and lateral hypothalamus

Brunke, O. R.; Bonauto, S.; Boshak, E. M.; Rauch, M. J.; Weera, M.

10.1101/2025.05.23.655819 — neuroscience — Posted on 2025-05-28

733 Longitudinal Habituation and Novelty Detection neural responses from infancy to early childhood in The Gambia and UK

Blasi Ribera, A.; Blanco Maniega, B.; McCann, S.; Mbye, E.; Touray, E.; Rozhko, M.; Milosavljevic, B.; Katus, L.; Saidykhand, M.; Ceesay, M.; Fadera, T.; Ghillia, G.; Perapoch Amado, M.; Moore, S. E.; Elwell, C. E.; Lloyd-Fox, S.

10.1101/2025.05.23.655801 — neuroscience — Posted on 2025-05-28

734 Unravelling neuromechanical constraints to finger independence

Mulla, D. M.; Tilley, P. M.; Keir, P. J.

10.1101/2025.05.23.655831 — neuroscience — Posted on 2025-05-28

735 A novel frameshift mutation in Phosphoinositide 3-kinase regulatory subunit 1 (PIK3R1) causes immunodeficiency and Amyotrophic Lateral Sclerosis (ALS)

Calco, B.; Sweeney, C. L.; Steiner, J.; Wang, T.; Markowitz, T. E.; Paul, S.; Palicha, B.; Dinges, S. S.; Yoo, K.; Henderson, L.; Mcdonald, V.; De Ravin, S. S.; Greenberg, B.; Zerbe, C.; Notarangelo, L. D.; Holland, S. M.; Nath, A.; Safavi, F.

10.1101/2025.05.23.655625 — neuroscience — Posted on 2025-05-28

736 A dataset of adult heart and liver mass after placental Insulin-like growth factor 1 overexpression and partial knockout in mice

Fairbairn, F. M.; Carver, A. J.; Taylor, R. J.; Stevens, H. E.

10.1101/2025.05.23.655797 — physiology — Posted on 2025-05-28

737 Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment

Chong, D. J. W.; Albulescu, L.-O.; Westhorpe, A. R.; Clare, R. H.; Marriott, A. E.; Woodley, C. M.; Gunasekar, R.; Mosallam, N.; Crittenden, E.; Stars, E.; Dawson, C. A.; Kool, J.; Wilkinson, M. C.; Leung, S. C.; Berry, N. G.; Casewell, N. R.; O.Neill, P. M.

10.1101/2025.05.23.655830 — pharmacology and toxicology — Posted on 2025-05-28

738 Modeling Atrial Fibrillation through Intermittent Tachypacing-Induced Remodeling in hiPSC-Derived Atrial Cardiomyocytes and Atrial Fibroblast

Kozlowski, P.; Muthukumarasamy, K. M.; Deshmukh, A.; Monteiro da Rocha, A.; Oral, H.

10.1101/2025.05.23.655123 — bioengineering — Posted on 2025-05-28

739 Replication stress alters CENP-A nucleosome stability during S phase

Lee, A. S.; Huang, C.-F.; Su, T.; Bodner, J.; Kelleher, N. L.; Foltz, D. R.

10.1101/2025.05.23.655122 — biochemistry — Posted on 2025-05-28

740 In-cell Proteomics Enables High-Resolution Spatial and Temporal Mapping of Early Xenopus tropicalis Embryos

Sun, J.; Xu, X.; Wei, S.; Yu, Y.

10.1101/2025.05.23.655823 — biochemistry — Posted on 2025-05-28

741 Evolution of resistance breaking in spinach downy mildew revealed through pangenome graph analysis

Skiadas, P.; Mendel, M.; Elberse, J.; Van den Ackerveken, G.; de Jonge, R.; Seidl, M. F.

10.1101/2025.05.23.655769 — genomics — Posted on 2025-05-28

742 Large haplotypes linked to climate and life history variation in divergent lineages of Atlantic salmon (Salmo salar)

Lehnert, S. J.; Kess, T.; Bentzen, P.; Barson, N.; Lien, S.; Dempson, J. B.; Bradbury, I. R.

10.1101/2025.05.23.655798 — genomics — Posted on 2025-05-28

743 Somitic Change Drives Changes in Vertebral Regionalisation in African Cichlids Despite Strong Canalisation of Somite Number

Bucklow, C. V.; Ribeiro, E. D.; Benson, R.; Verd, B.

10.1101/2025.05.23.655800 — evolutionary biology — Posted on 2025-05-28

744 Modelling the effectiveness of Integrated Pest Management strategies for the control of Septoria tritici blotch

Vincent, E. M. R.; Hill, E. M.; Parnell, S.

10.1101/2025.02.28.639837 — ecology — Posted on 2025-05-28

745 NeMO: a flexible R package for nested multi-species occupancy modelling and eDNA study optimization

Mace, B.; Manel, S.; Valentini, A.; Rocle, M.; Roset, N.; Delrieu-Trottin, E.

10.1101/2025.05.23.655794 — ecology — Posted on 2025-05-28

746 Pre-dauer starvation decouples somatic from germline development with lifelong reproductive consequences in C. elegans

Koitz, F. A.; Miller, C. P.; Gordon, K. L.

10.1101/2025.05.23.655783 — developmental biology — Posted on 2025-05-28

747 Reciprocal Regulation Between the SCFFBXO24 Ubiquitin E3 Ligase and FoxP1 Protein

Maloy, A.; Walter, S.; Mascilli, A.; Klein, D.; Lardo, S.; Londino, J.; Nyunoya, T.; McDyer, J.; Mai, S.; Zeng, X.; Yates, N.; Cantrell, P.; Hainer, S.; Mallampalli, R.; Chandra, D.

10.1101/2025.05.23.653845 — molecular biology — Posted on 2025-05-28

748 Effects of C3aR activated mast cells in eosinophilic esophagitis

Zhang, S.; Cavallaro, D.; Xia, M.; Ben-Baruch Morgenstern, N.; Shoda, T.; Osswald, G. A.; Bolton, S.; Mukkada, V.; Dunn, J.; Felton, J.; Rochman, M.; Caldwell, J. M.; Derakhshan, T. M.; Rothenberg, M.

10.1101/2025.05.23.655738 — immunology — Posted on 2025-05-28

749 Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

Li, T.; Lu, L.; Qiu, J.; Dong, X.; Yang, L.; He, K.; Gu, Y.; Zhou, B.; Jia, T.; Lawrence, T.; Malissen, M.; Wang, G.; Huang, R.; Wang, H.; Malissen, B.; Liang, Y.; Zhang, L.

10.1101/2025.05.23.655779 — immunology — Posted on 2025-05-28

750 Hyperactivity of the Amygdala Mediates Depressive-Like Phenotypes and Decreased Serotonin Release

Kim, K.; Lai, Y.; Gao, Q.; Wang, H.; ying, K. T.; Asim, M.; He, J.

10.1101/2025.03.10.642393 — neuroscience — Posted on 2025-05-28

751 Optimized Theta Burst Stimulation with Extended Intervals Enhances Excitatory-Inhibitory Balance

Salimi, M.; Nazari, M.; Mishler, J.; Rodger, J.; Jomehpour, S.; Mishra, J.; Ramanathan, D.

10.1101/2024.08.19.608693 — neuroscience — Posted on 2025-05-28

752 Impact of Dysbiosis and Antiseizure Medication on Seizure Pathophysiology in a Viral Infection-Induced Epilepsy Model

Shonka, S.; Erickson, I.; Park, H.; Barker-Haliski, M.

10.1101/2025.05.23.655804 — neuroscience — Posted on 2025-05-28

753 Pathogenic variants in autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation

Singh, K.; Dafsari, H. S.; Gillham, O.; Chi, H.; Mandzhukova, I.; Kourouzidou, I.; Sheshadri, P.; Chung, C.-Y.; Pingitore, V.; Vansenne, F.; Selwood, D. L.; Pendin, D.; Szabadkai, G.; Fanto, M.; Jungbluth, H.; Duchen, M. R.

10.1101/2025.05.23.655806 — neuroscience — Posted on 2025-05-28

754 Optimizing short-channel regression in fNIRS: an empirical evaluation in a naturalistic multimodal paradigm

Lemaire, Y.; Barone, P.; Strelnikov, K.; Deguine, O.; Caclin, A.; Ginzburg, J.

10.1101/2025.05.23.655796 — neuroscience — Posted on 2025-05-28

755 Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimers disease reveals differences dependent on genotype and sex

Ladurner, G.; Merkle, C. W.; May, L.; Worm, S.; Patel, Y.; Varaka, M.; Daurer, M.; Jauk, L.; Rabl, R.; Koenigshofer, P.; Garhoefer, G.; Prokesch, M.; Baumann, B.

10.1101/2025.05.23.655771 — neuroscience — Posted on 2025-05-28

756 Amygdalar Calcitonin Gene-Related Peptide Driven Effects of Cold Sensitivity Induced by Peripheral Neuropathy in Mice

Trail, A. D.; Allen, H. N.; Nelson, T. S.; Widner, J. A.; Lewter, L.; Tack, S. H.; Kolber, B.

10.1101/2025.05.23.655813 — neuroscience — Posted on 2025-05-28

757 Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.

Kakava, S.; Robert, J.

10.1101/2025.05.23.655828 — neuroscience — Posted on 2025-05-28

758 Effects of Three Natural Dietary Compounds on Insect Pests

Cabello, T.; Gamez, M.

10.1101/2025.05.23.655814 — zoology — Posted on 2025-05-28

759 Spillover rate is not a predictor of host jump risk, but spillover novelty is

Simony, B. J.; Kennedy, D. A.

10.1101/2024.10.14.618291 — systems biology — Posted on 2025-05-28

760 Phenylketonuria: modelling cerebral amino acid and neurotransmitter metabolism

Wegrzyn, A. B.; van Vliet, D.; van Eunen, K.; Heiner-Fokkema, M. R.; van der Zee, E. A.; van Spronsen, F.; Bakker, B. M.

10.1101/2024.01.05.574352 — systems biology — Posted on 2025-05-28

761 Mutation of a conserved stromal C-terminus threonine residue of Photosystem II subunit S slows down NPQ induction and speeds up relaxation.

Chin, W. Y.; Walter, J.; Robijns, A.; Kromdijk, J.

10.1101/2025.05.23.655821 — plant biology — Posted on 2025-05-28

762 High burden of premature ventricular contractions upregulates transcriptional markers of inflammation and promotes adverse cardiac remodeling linked to cardiomyopathy

Medina-Contreras, J. L.; Balderas-Villalobos, J.; Gomez-Arroyo, J.; Hayles, J.; Kaszala, K.; Tan, A. Y.; Samso, M.; Huizar, J. F.; Eltit, J. M.

10.1101/2025.05.23.652709 — physiology — Posted on 2025-05-28

763 Prolonged fasting and glucocorticoid exposure drive dynamic DNA methylation in elephant seals

Gibson, E. F.; Torres-Velarde, J. M.; Ensminger, D. C.; Moreno-Santillan, D. D.; Crocker, D. E.; Vazquez-Medina, J. P.

10.1101/2025.05.23.654932 — physiology — Posted on 2025-05-28

764 In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

Ramirez, M. F.; Gour, A.; Sniffen, S. E.; Watson, E.; Sharma, A.; Wesson, D. W.

10.1101/2025.05.23.655803 — pharmacology and toxicology — Posted on 2025-05-28

765 Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia

Datar, G. K.; Khabusheva, E.; Anand, A.; Beale, J.; Sadek, M.; Chen, C.-W.; Potolitsyna, E.; Alcantara-Contessoto, N.; Liu, G.; De La Fuente, J.; Dollinger, C.; Guzman, A.; Martell, A.; Wohlan, K.; Maiti, A.; Short, N. J.; Yi, S. S.; Andresen, V. K.; Gjertsen, B. T.; Falini, B.; Rau, R. E.; Brunetti, L.; Sahni, N.; Goodell, M. A.; Riback, J. A.

10.1101/2025.05.23.655671 — biophysics — Posted on 2025-05-28

766 Joint Modeling of Longitudinal Biomarker and Survival Outcomes with the Presence of Competing Risk in Nested Case-Control Studies with Application to the TEDDY Microbiome Dataset

Zhao, Y.; Lee, T.; Zhou, B.; wang, c.; Schmidt, A. M.; Liu, M.; Li, H.; Hu, J.

10.1101/2025.05.23.655653 — bioinformatics — Posted on 2025-05-28

767 Sequencing the gaps: dark genomic regions persist in CHM13 despite long-read advances

Wadsworth, M. E.; Page, M. L.; Aguzzoli Heberle, B.; Miller, J. B.; Steely, C.; Ebbert, M. T. W.

10.1101/2025.05.23.655776 — bioinformatics — Posted on 2025-05-28

768 Evaluation of network inference algorithms for derivation of metabolic relationships from lipidomic and metabolomic datasets

Archinuk, F.; Greenyer, H.; Stege, U.; Bennett, S. A. L.; Cuperlovic-Culf, M.; Jabbari, H.

10.1101/2025.05.23.654112 — bioinformatics — Posted on 2025-05-28

769 A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis

Schaart, J. M.; Wasserberg, D.; Eufrasio Cruz, M. A.; Kea-te Lindert, M.; Van der Meijden, R. H. M.; Roverts, R.; Debera, N. D.; Lu, M. P.; Rouwkema, J.; Nijhuis, W. H.; van der Meer, A. D.; Jonkheijm, P.; Sommerdijk, N.; Akiva, A.

10.1101/2024.07.31.605958 — bioengineering — Posted on 2025-05-28

770 A Modular Microfluidic System to Generate Gradient Hydrogels with Simple-to-Complex Stiffness Profiles for Mechanobiology

Chong, S. W.; Sardharwalla, J.; Masonsong, G. S. P.; Cosgrove, J.; Katselas, A.; Gresham, I. J.; Bilek, M. M.; Shen, Y.; Neto, C.; Vigolo, D.

10.1101/2025.05.23.655778 — bioengineering — Posted on 2025-05-28

771 Optimal competitors: the balance of attraction and choices of mutualists, like pollinators, drives facilitation and may promote crop pollination

Dornhaus, A.; Houston, A.

10.1101/2024.10.29.620963 — ecology — Posted on 2025-05-28

772 Quantifying phage infectivity from characteristics of bacterial population dynamics

Blazanin, M.; Vasen, E.; Jolis, C. V.; An, W.; Turner, P.

10.1101/2023.06.29.546975 — microbiology — Posted on 2025-05-28

773 Priming the pump: Enhanced nitrite release in response to a nitrate pulse by nitrogen-limited Prochlorococcus

Berube, P. M.; LeMaster, T.; Chisholm, S. W.

10.1101/2025.05.13.653865 — microbiology — Posted on 2025-05-28

774 COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID

DeLine-Caballero, S.; Ratnasiri, K.; Chen, H.; Sahagun, S. J.; Mangalanathan, U. M.; Barnard, T. R.; Turk, N.; Yang, J.; Saini, N.; Ayhan, E. M.; Memetimin, H.; Finlin, B. S.; Licht, Z.; Kern, P. A.; Emery, I.; Leeman, B.; Edelstein, G. E.; Costa, S.; Choi, A.; Licht, J. Z.; Rosen, C.; McLaughlin, T.; Blish, C. A.

10.1101/2025.05.23.655815 — immunology — Posted on 2025-05-28

775 When blood needs to flow: The role of the complement system in red blood cell clearance during immune responses

Arias, C. F.; Tortajada, A.; Acosta, F. J.; Fernandez-Arias, C.

10.1101/2025.05.23.655770 — immunology — Posted on 2025-05-28

776 Individual Alpha Frequency Predicts the Sensitivity of Time Perception

Morrow, A.; Wilson, M.; Geller-Montague, M.; Soldano, S.; Hajidamji, S.; Samaha, J.

10.1101/2024.12.16.628734 — neuroscience — Posted on 2025-05-28

777 Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation

Seon, H.; Chung, D.

10.1101/2024.09.03.611019 — neuroscience — Posted on 2025-05-28

778 FAIMS-GPF XL-MS: crosslinking-mass spectrometry based on gas-phase fractionation

Gizardin-Fredon, H.; Terrosu, S.; Pichard, S.; Korkut, D.; Braun, C.; Poterszman, A.; Charenton, C.; Cianferani, S.

10.1101/2025.05.23.655748 — systems biology — Posted on 2025-05-28

779 TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

Tamada, K.; Tomisawa, E.; Kuwata, S.; Miyake, T.; Nagayasu, K.; Kaneko, S.; Shibasaki, K.; Shirakawa, H.

10.1101/2025.05.23.655698 — pharmacology and toxicology — Posted on 2025-05-28

780 Modeling neural coding in the auditory midbrain with high resolution and accuracy

Drakopoulos, F.; Pellatt, L.; Sabesan, S.; Xia, Y.; Fragner, A.; Lesica, N. A.

10.1101/2024.06.17.599294 — bioengineering — Posted on 2025-05-28

781 Radical Footprinting in Mammalian Whole Blood

Zhao, M.; Tobin, L.; Misra, S. K.; Sharma, A.; Locklar, J.; Shami, A.; Mobarak, S.; Liu, H.; Jones, L. M.; Stewart, J. A.; Sharp, J. S.

10.1101/2024.09.29.615683 — biochemistry — Posted on 2025-05-28

782 Nickel binding to c-Src SH3 domain facilitates crystallization

Calicdan, X.; Fisher, O. S.; Ha, B. H.; Boggon, T. J.; Stiegler, A. L.

10.1101/2025.05.08.652639 — biochemistry — Posted on 2025-05-28

783 Genomic footprint of a shared Type 5 prophage in 'Candidatus Liberibacter asiaticus' and 'Candidatus Liberibacter africanus', two destructive bacterial pathogens of citrus huanglongbing

Labbe, F.; Boyer, C.; Clavijo-Coppens, F.; Benoist, B.; Turpin, P.; Ravelomanantsoa, S.; Pruvost, O.

10.1101/2025.05.23.655732 — genomics — Posted on 2025-05-28

784 Actin Networking Collapse Under STAT5A Deficiency Drives Mitochondrial Dysfunction and Autocrine IFN-beta Production

Sun, B.; Krishnamohan, M.; Nevo, R.; Zoler, E.; Geiger, B.; Schreiber, G.

10.1101/2025.05.26.656095 — cell biology — Posted on 2025-05-28

785 A glycan atlas of the mammalian intestine through ontogeny and inflammation

Siegel, S. J.; Pomerantz, D.; Heimburg-Molinaro, J.; Mahmood, S. D.; Korzenik, J. R.; Cummings, R. D.; Rakoff-Nahoum, S.

10.1101/2025.03.06.641959 — microbiology — Posted on 2025-05-28

786 Success of GDNF-based treatment of Hirschsprung disease depends on NCAM1 signaling and various subtypes of enteric neural progenitors

Gary, A.; Soret, R.; Lefevre, M. A.; Lassoued, N.; Aspirot, A.; Faure, C.; Pilon, N.

10.1101/2025.05.23.655388 — neuroscience — Posted on 2025-05-28

787 Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation

Wang, J.; Nishiyama, J.; Parra-Bueno, P.; Okaz, E.; Oz, G.; Liu, X.; Watabe, T.; Suponitsky-Kroyter, I.; McGraw, T. E.; Szatmari, E. M.; Yasuda, R.

10.1101/2022.05.17.492345 — neuroscience — Posted on 2025-05-28

788 VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution

Dang, V.; Voigt, B.; Yang, D.; Hoogerbrugge, G.; Lee, M.; Cox, R.; Papoulas, O.; McWhite, C. D.; Pradeep, R.; Leggere, J. C.; Gray, R. S.; Marcotte, E. M.

10.1101/2025.05.26.656196 — systems biology — Posted on 2025-05-28

789 The Single-cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors

Hawkins, A. G.; Shapiro, J. A.; Spielman, S. J.; Mejia, D. S.; Venkatesh Prasad, D.; Ichihara, N.; Yakovets, A.; Gottlieb, A. M.; Wheeler, K. G.; Bethell, C. J.; Foltz, S. M.; O'Malley, J.; Greene, C. S.; Taroni, J. N.

10.1101/2024.04.19.590243 — bioinformatics — Posted on 2025-05-28

790 Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain

Kong, D.; He, H.; Lechner, J.; Yang, J.; Zhang, A.; li, L.; Mathur, R.; Darland, D.; Takaku, M.; Lu, L.; Peng, J.; Yang, K.; Wang, X.

10.1101/2025.05.01.651759 — bioinformatics — Posted on 2025-05-28

791 Genetic and phenotypic variation between Tetranychus ludeni populations from Benelux

Kant, M. R.; Villacis-Perez, E.

10.1101/2025.05.23.655751 — evolutionary biology — Posted on 2025-05-28

792 Neutral genetic diversity during selective sweeps in non-recombining populations

Kaushik, S.; Jain, K.; Johri, P.

10.1101/2024.09.12.612756 — evolutionary biology — Posted on 2025-05-28

793 Groundwater and phenology data reveal vulnerability of riparian trees to drought

Mohammadi, R. M.; Dawson, T. E.; Tiedeman, C. R.; Stella, J.; Ruhi, A.

10.1101/2025.05.23.654357 — ecology — Posted on 2025-05-28

794 Fundamental limits on patterning by Turing-like reaction-diffusion mechanisms

Muzatko, D.; Daga, B.; Hiscock, T. W.

10.1101/2025.05.27.656324 — developmental biology — Posted on 2025-05-28

795 Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read Nanopore sequencing

Pastore, S.; Wacheul, L.; Lehmann, L.; Muendnich, S.; Lutz, B.; Helm, M.; Gerber, S.; Lafontaine, D. L.; Butto, T.

10.1101/2025.03.01.640970 — cell biology — Posted on 2025-05-28

796 Transposable Element Derepression-mediated IFN-I Signaling Enhances Stem/Progenitor Cell Activity After Irradiation

Cinat, D.; van der Wal, R.; Baanstra, M.; Gamez, A. A. S.; Jellema-de Bruin, A.; Brouwer, U.; van Goethem, M.-J.; van Vugt, M.; Barazzuol, L.; Coppes, R. P.

10.1101/2024.02.14.580306 — cell biology — Posted on 2025-05-28

797 DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation

Koo, A. S.-H.; Jia, W.; Kim, S. H.; Scalf, M.; Boos, C. E.; Chen, Y.; Wang, D.; Voter, A. F.; Bajaj, A.; Smith, L. M.; Keck, J. L.; Bakkenist, C. J.; Guo, L.; Tibbetts, R. S.

10.1101/2024.10.29.619708 — molecular biology — Posted on 2025-05-28

798 NEUROGLIAL CB1 RECEPTORS CONTROL NAVIGATION STRATEGIES

Egana-Huguet, J.; Sangroniz-Beltran, L.; Baraibar, A. M.; Reyes-Velasquez, P.; Landgraf, N.; Torres-Maldonado, P.; Rodriguez-Cedres, C.; Julio-Kalajzic, F.; Piriz, J.; Ramos-Uriarte, A.; Grandes, P.; Marsicano, G.; Mato, S.; Ceprian, M.; Soria-Gomez, E.

10.1101/2025.05.27.656352 — neuroscience — Posted on 2025-05-28

799 A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex

Hanes, C. M.; Steffen, D. M.; Murray, G. C.; Burgess, R. W.; Weiner, J. A.; Garrett, A. M.

10.1101/2025.05.28.656572 — neuroscience — Posted on 2025-05-28

800 Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

Ahuja, K.; Ramezankhani, R.; Wang, X.; Burg, T.; Amos, G.; Neyrinck, K.; Silva, A.; Arekatla, G.; Cassidy, E. E.; Nami, F.; Terryn, J.; Wierda, K.; Vints, K.; Vandamme, N.; Poovathingal, S.; Lambrichts, I.; Swinnen, J. V.; Van Den Bosch, L.; De Groef, L.; Moons, L.; Verfaillie, C.; Neyts, J.; Jochmans, D.; Chai, Y. C.

10.1101/2025.05.28.656435 — neuroscience — Posted on 2025-05-28

801 MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets

Dell'Acqua, F.; Beyh, A.; Stones, R.; Barrett, R. L.; De Santiago Requejo, F.; Laguna, P. L.; Lacerda, L. M.; Davison, C.; Leslie, A.; Howells, H.; Goldstein, L. H.; Williams, S. C.; Catani, M.

10.1101/2025.05.27.656234 — neuroscience — Posted on 2025-05-28

802 Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice

Reina-Campos, M.; Gallego-Landin, I.; Medrano, M.; Valverde, O.

10.1101/2025.05.28.656556 — neuroscience — Posted on 2025-05-28

803 Mental calculation: the fastest high-level cognitive ability of human beings?

Wiederhold, B.

10.1101/2025.05.28.656137 — neuroscience — Posted on 2025-05-28

804 Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Terceros, A.; Chen, C.; Harada, Y.; Eilers, T.; Gebremedhin, M.; Koche, R. P.; Hamard, P.-J.; Sharma, R.; Rajasethupathy, P.

10.1101/2025.05.28.656415 — neuroscience — Posted on 2025-05-28

805 Thermal proteome profiling identifies mitochondrial aminotransferases involved in cysteine catabolism via persulfides in plants

Heinemann, B.; Moormann, J.; Bady, S.; Angermann, C.; Schrader, A.; Hildebrandt, T. M.

10.1101/2025.05.23.655777 — plant biology — Posted on 2025-05-28

806 EBSn, a robust synthetic reporter for monitoring ethylene responses in plants

Fernandez-Moreno, J.-P.; Fenech, M.; Yaschenko, A. E.; Zhao, C.; Neubauer, M.; Davis, H. N.; Marchi, A. J.; Concannon, R.; Keren-Keiserman, A.; Reuveni, M.; Levitsky, V. G.; Oshchepkov, D.; Dolgikh, V.; Goldshmidt, A.; Ascencio-Ibanez, J. T.; Zemlyanskaya, E.; Alonso, J. M.; Stepanova, A. N.

10.1101/2025.05.23.655144 — plant biology — Posted on 2025-05-28

807 Transcriptional Condensates Encode a "Golden Mean" to Optimize Enhancer-Promoter Communication across Genomic Distances

Zhu, T.; Li, C.; Chu, X.

10.1101/2025.05.27.656519 — biophysics — Posted on 2025-05-28

808 RNA localization to nuclear speckles follows splicing logic

Wen, L.; Arias, M. A.; Fan, X.; Paul, S.; Liao, S. E.; Sobczyk, M.; Regev, O.; Fei, J.

10.1101/2025.05.28.656493 — biochemistry — Posted on 2025-05-28

809 Genetic Mapping in Diversity Outbred Mice Identifies Novel Loci and Candidate Genes for Anxiety-Like Behavior and Genetic Subgroups Predictive of Ethanol Consumption

Tatom, Z.; Mignogna, K. M.; Macleod, L.; Sergi, Z.; Miles, M. F.

10.1101/2025.05.27.656445 — animal behavior and cognition — Posted on 2025-05-28

810 Male gut microbiome mediates post-mating sexual selection in Drosophila

Maggu, K.; Meena, A.; De Nardo, A. N.; Sbilordo, S. H.; Roy, J.; Lüpold, S.

10.1101/2025.05.23.655737 — evolutionary biology — Posted on 2025-05-28

811 Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors

Segarra, L. C.; Sangster, K.; Sagner, J.; Kania, A.; Sagner, A.

10.1101/2025.05.27.656404 — developmental biology — Posted on 2025-05-28

812 Tissue signatures of human macrophages during homeostasis and activation

Caron, D. P.; Specht, W. L.; Chen, D.; Wells, S. B.; Szabo, P. A.; Sims, P. A.; Farber, D. L.

10.1101/2025.05.23.655632 — immunology — Posted on 2025-05-28

813 Comparing Brain-Behavior Relationships Across Dimensional, Tail-Sampled, and Propensity-Matched Models

Murtha, K.; Dorfschmidt, L.; Bethlehem, R. A. I.; Kang, K.; Vandekar, S.; Alexander-Bloch, A. F.; Waller, R.; Seidlitz, J.

10.1101/2025.05.23.655740 — neuroscience — Posted on 2025-05-28

814 The Effect of Previously Encountered Sensory Information on Neural Representations of Predictability: Evidence from Human EEG

Magami, K.; Bianco, R.; Hall, E.; Pearce, M.; Chait, M.

10.1101/2025.05.27.656332 — neuroscience — Posted on 2025-05-28

815 Gut microbe-derived lactic acid optimizes host energy metabolism during starvation

Millington, J. W.; Lopez, J. A.; Sajjadian, A. M.; Scheffler, R. J.; DeFelice, B. C.; Ludington, W. B.; Good, B. H.; O'Brien, L. E.; Huang, K. C.

10.1101/2025.05.27.656452 — physiology — Posted on 2025-05-28

816 Evaluate the effectiveness of various small RNA alignment techniques in transcriptomic analysis by examining different sources of variability through a multi-alignment approach

Zhao, X.; Korsching, E.

10.1101/2025.02.18.638849 — bioinformatics — Posted on 2025-05-28

817 Evolutionary Influences on Local Patterns of Genetic Relatedness

Smith, T. Q.; Rahman, A.; Schaeffer, S. W.; Szpiech, Z. A.

10.1101/2025.05.02.651970 — evolutionary biology — Posted on 2025-05-28

818 Description of a new Telonemia genus and species with novel observations providing insights into its hidden diversity

Mostazo-Zapata, H.; Galvez-Morante, A.; Berney, C.; Maya-Figuerola, X.; Sigona, C.; Lopez-Escardo, D.; Sa, E. L.; Vaque, D.; Richter, D. J.

10.1101/2025.05.28.656552 — evolutionary biology — Posted on 2025-05-28

819 Evolution of antivirus defense in prokaryotes depending on the environmental virus prevalence and virome dynamics

Babajanyan, S.; Garushyants, S. K.; Wolf, Y. I.; Koonin, E. V.

10.1101/2025.05.27.656525 — evolutionary biology — Posted on 2025-05-28

820 Analyses of 37 composts revealed microbial taxa associated with disease suppressiveness

Logo, A.; Boppre, B.; Fuchs, J.; Maurhofer, M.; Oberhaensli, T.; Thuerig, B.; Widmer, F.; Mayerhofer, J.; Flury, P.

10.1101/2025.01.17.633646 — molecular biology — Posted on 2025-05-28

821 ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy

Miller, C.; Morrison, J. H.; Bankers, L.; Dran, R.; Kendrick, J.; Briggs, E.; Ferguson, V. L.; Poeschla, E. M.

10.1101/2025.01.21.634124 — immunology — Posted on 2025-05-28

822 The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

Peukes, J.; Lovatt, C.; Leistner, C.; Boulanger, J.; Morado, D. R.; Fuller, M. J. G.; Kukulski, W.; Zhu, F.; Komiyama, N. H.; Briggs, J. A. G.; Grant, S. G. N.; Frank, R. A. W.

10.1101/2021.02.19.432002 — neuroscience — Posted on 2025-05-28

823 Embodied decisions as active inference

Priorelli, M.; Stoianov, I. P.; Pezzulo, G.

10.1101/2024.05.28.596181 — neuroscience — Posted on 2025-05-28

824 Small-world scale-free brain networks from EEG with application to motor imagery decoding and brain fingerprinting

Khalili, M. D.; Abootalebi, V.; Saeedi-Sourck, H.; Santoro, A.; Behjat, H. H.

10.1101/2025.04.17.649421 — neuroscience — Posted on 2025-05-28

825 The Spinal Cord-Gut Axis Regulates Gut Microbial Homeostasis: Insights from a New Murine Metagenomic Catalog

Mohssen, M.; Zayed, A. A.; Kigerl, K.; Du, J.; Smith, G. J.; Schwab, J. M.; Sullivan, M. B.; Popovich, P. G.

10.1101/2025.05.27.656368 — microbiology — Posted on 2025-05-28

826 Harnessing Microbial Tools: Escherichia coli as a Vehicle for Neuropeptide Functional Analysis in Caenorhabditis elegans

Srinivasan, J.; Diloreto, E. M.; Shastry, S.; Leptich, E. J.; Reilly, D. K.; Arey, R. N.

10.1101/2025.03.03.641308 — neuroscience — Posted on 2025-05-28

827 Neural responses prior to licking onset in the striatal matrix compartment in mice

Ishimaru, Y.; Yoshizawa, T.; Kimoto, T.; Inui, T.; Yawaka, Y.; Funahashi, M.

10.1101/2025.05.23.655747 — neuroscience — Posted on 2025-05-28

828 Evaporative cooling signals for wound healing in plants

Balem, J. M.; Tan, C.; Dias, N. C. F.; Arnold, M. L.; Tran, S.; Severns, P. M.; Teixeira, P. J. P. L.; Li, C.; Yang, L.

10.1101/2025.05.23.655667 — plant biology — Posted on 2025-05-28

829 P(all-atom) Is Unlocking New Path For Protein Design

Qu, W.; Guan, J.; Ma, R.; Zhai, K.; Wu, W.; Wang, H.

10.1101/2024.08.16.608235 — bioinformatics — Posted on 2025-05-28

830 Automated evaluation of single-cell reference atlas mappings enables the identification of disease-associated cell states

Sikkema, L.; Lkandushi, M.; Scarcella, D.; Moinfar, A. A.; Engelmann, J. P.; Theis, F. J.

10.1101/2025.05.23.655749 — bioinformatics — Posted on 2025-05-28

831 Binding mode of isoxazolyl penicillins to a Class-A beta-lactamase at ambient conditions

Gore, G.; Prester, A.; Stetten, D. v.; Bartels, K.; Schulz, E. C.

10.1101/2025.05.23.655743 — biochemistry — Posted on 2025-05-28

832 A high degree of clonal reproduction and aggregated structure of milkweed clones does not affect ramet sexual reproduction

Machiorlete, H.; Puzey, J.; Dalgleish, H. J.

10.1101/2025.05.23.655745 — ecology — Posted on 2025-05-28

833 Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the anterior brainstem

Kilpinen, S.; Virtanen, L.; Bodington Celma, S.; Bonsdorff, A.; Heliölä, H.; Achim, K.; Partanen, J.

10.1101/2025.01.26.634960 — developmental biology — Posted on 2025-05-28

834 CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages

Hovhannisyan, G. G.; Akhourbi, T.; Eski, S. E.; Pirson, I.; Gurzov, E. N.; Singh, S. P.

10.1101/2025.05.23.655316 — developmental biology — Posted on 2025-05-28

835 Quantification of grapevine yield losses as a function downy mildew severity on foliage and cluster

Fabre, F.; Delbac, L.; Poeydebat, C.; Zaffaroni, M.

10.1101/2024.02.28.582447 — microbiology — Posted on 2025-05-28

836 Horizontal Gene Transfer Inference: Gene presence-absence outperforms gene trees

Mishra, S.; Lercher, M. J.

10.1101/2024.12.27.630302 — bioinformatics — Posted on 2025-05-28

837 Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response

Fan, J.; Dhingra, N.; Yang, T.; Yang, V.; Zhao, X.

10.1101/2024.03.28.587206 — molecular biology — Posted on 2025-05-28

838 Can Pupillometry Reveal Perturbation Detection in Sensorimotor Adaptation during Grasping?

Pfalz, L.; Müller, C.; Kopiske, K.

10.1101/2025.05.15.654224 — neuroscience — Posted on 2025-05-28

839 Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA)

Smith, R. E.; Christena, R. L.; Michno, B. J.; O'Dea, F.; Davis, J. L.; Lidbury, I. D.; Alaman-Zarate, M.; Stefanidi, D.; Maes, E.; Fisher, H.; Prajsnar, T. K.; Mesnage, S.

10.1101/2024.11.26.625352 — microbiology — Posted on 2025-05-28

840 High-throughput screening for class I peptide MHC binding via yeast surface display

Holec, P. V.; Breuckman, K. C.; Leddy, O.; White, F. M.; Bryson, B. D.; Birnbaum, M. E.

10.1101/2025.05.24.655874 — immunology — Posted on 2025-05-28

841 Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease

Cocuzza, C. V.; Chopra, S.; Segal, A.; Labache, L.; Chin, R.; Joss, K.; Holmes, A. J.

10.1101/2025.05.23.655864 — neuroscience — Posted on 2025-05-28

842 EEG Signature of Idiopathic Hypersomnia: Insights from Sleep Microarchitecture and Hypnodensity Metrics

Le Coz, A.; Vollhardt, R.; Champetier, P.; Herzog, R.; Leu-Semenescu, S.; Dodet, P.; Attali, V.; Gales, A.; Oudiette, D.; Arnulf, I.; Andrillon, T.

10.1101/2025.05.26.656134 — neuroscience — Posted on 2025-05-28

843 Cholinergic synaptic plasticity shapes resilience and vulnerability to tau

Onuska, K. M.; Devito, L. A.; Shanks, H. R.; Qi, Q.; Crooks, A. M.; Haast, R. A.; Andrews, T. S.; Williams, K. M.; Beraldo, F. H.; Qiu, T.; Fajardo-Valdez, A.; Wearn, A.; Turner, G. R.; Thiessen, J. D.; Fox, M. S.; Hicks, J. W.; Bussey, T. J.; Saksida, L. M.; Tremblay-Mercier, J.; Breitner, J. C.; Soucy, J.-P.; Poirier, J.; Villeneuve, S.; Prado, V. F.; Prado, M. A.; Spreng, R. N.; Schmitz, T. W.; for the PREVENT-AD Research Group,

10.1101/2025.05.27.656174 — neuroscience — Posted on 2025-05-28

844 Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes

Grodem, E. O. S.; Vidal-Pineiro, D.; Sorensen, O.; Bartres-Faz, D.; Brandmaier, A. M.; Cattaneo, G.; Garrido, P. F.; Henson, R. N.; Kühn, S.; Lindenberger, U.; MacIntosh, B. J.; Nyberg, L.; Pascual-Leone, A.; Smith, S. M.; Sole-Padulles, C.; Solana-Sanchez, J.; Watne, L. O.; Walhovd, K. B.; Bjornerud, A.; Fjell, A. M.

10.1101/2025.05.26.655710 — neuroscience — Posted on 2025-05-28

845 The evolution of interdisciplinarity and internationalization in scientific journals

Zhou, H.; Amaral, L. A. N.

10.1101/2025.05.26.656082 — scientific communication and education — Posted on 2025-05-28

846 β2-integrins as biomarkers in urothelial cancer

Fagerholm, S. C.; Asens, M. L.; Khan, I.

10.1101/2025.05.25.656033 — cancer biology — Posted on 2025-05-28

847 Direct observation of conformational dynamics of intrinsically disordered proteins at the single-molecule level

Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.

10.1101/2025.05.26.656162 — biophysics — Posted on 2025-05-28

848 Lipid gating of BK channels and mechanism of activation by negatively charged lipids

Mironenko, A.; de Groot, B. L.; Kopec, W.

10.1101/2025.05.27.656279 — biophysics — Posted on 2025-05-28

849 Proteonano: A Robust Platform for Large Cohort Deep Plasma Proteomic Studies

Wu, H.; Zhang, Y.; Wang, Y.; Ouyang, X.

10.1101/2024.08.20.608582 — biochemistry — Posted on 2025-05-28

850 Individual difference in social learning in a granivorous passerine bird, and its independence from personality

Frascotti, A.; Silva, R.; Mota, P. G.

10.1101/2025.03.05.641444 — animal behavior and cognition — Posted on 2025-05-28

851 Reappraisal of the place of cultivated plants in the carbon budget

Muller-Feuga, A.

10.1101/2025.05.17.654640 — ecology — Posted on 2025-05-28

852 Comparative analysis of the radiobiological effects of laser-driven VHEE vs. conventional electrons using in vitro, ex vivo, and in vivo models

Giaccaglia, C.; Bayart, E.; Dubail, M.; Varma, C.; Heinrich, S.; Gautier, J.; Tafzi, A.; Kononenko, L.; Goddet, J.-p.; Lamarre-Jouenne, I.; Fouillade, C.; Flacco, A.

10.1101/2025.05.27.656200 — cell biology — Posted on 2025-05-28

853 Box C/D snoRNPs and MDT-15/MED15 regulate mitochondrial surveillance via fatty acid metabolism

Armendariz, L.; Chan, A.; Tjahjono, E.; Wang, M.; Kirienko, N. V.

10.1101/2025.05.26.656193 — cell biology — Posted on 2025-05-28

854 Mechanism of phosphorylation dependent interactions of complete Retinoblastoma-AB pocket domain with its linker

Keshava, K. P.; Bhattacherjee, A.; GHOSH, I.; Tiwari, S.

10.1101/2025.05.27.656056 — cell biology — Posted on 2025-05-28

855 Lactic acid influences iron assimilation by a fungal pathogen via the iron reductive uptake pathway

Gomes-Goncalves, A.; Van Genechten, W.; Ataide, P.; Barata Antunes, C.; Ghasemi, F.; Casal, M.; Teixeira, M. C.; Arino, J.; Brown, A. J. P.; Van Dijck, P.; Paiva, S.

10.1101/2025.05.27.656276 — cell biology — Posted on 2025-05-28

856 Repeated duplications and losses shaped SMC complex evolution from archaeal ancestors to modern eukaryotes

van Hooff, J. J. E.; Raas, M. W. D.; Tromer, E. C.; Eme, L.

10.1101/2024.01.07.573240 — cell biology — Posted on 2025-05-28

857 Structure of the conjugation surface exclusion protein TraT

Chen, N.; Bukys, A.; Lundgren, C. A.; Deme, J. C.; El Sayyed, H.; Kapanidis, A. N.; Lea, S. M.; Berks, B. C.

10.1101/2025.05.27.656304 — microbiology — Posted on 2025-05-28

858 Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol.

GSCHWIND, R.; Bonnet, M.; Abramova, A.; Jarquin Diaz, V. H.; Wenne, M.; Loeber, U.; Godron, N.; Kampouris, I. D.; Tskhay, F.; Nahid, F.; Debroucker, C.; Bui-Hai, M.; El Aiba, I.; Klumper, U.; Berendonk, T. U.; Forslund-Startceva, S. K.; Zahra, R.; Bengtsson-Palme, J.; RUPPE, E.

10.1101/2025.05.26.656069 — microbiology — Posted on 2025-05-28

859 Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

Solomon, P. A. J.; Budde, M.; Kohshour, M. O.; Adorjan, K.; Heilbronner, M.; Navarro-Flores, A.; Papiol, S.; Reich-Erkelenz, D.; Schulte, E. C.; Senner, F.; Vogl, T.; Kaurani, L.; Krugger, D. M.; Sananbenesi, F.; Pena, T.; Burkhardt, S.; Schutz, A.-L.; Anghelescu, I.-G.; Arolt, V.; Baune, B. T.; Dannlowski, U.; Dietrich, D. E.; Fallgatter, A. J.; Figge, C.; Juckel, G.; Konrad, C.; Lang, F. U.; Reimer, J.; Reininghaus, E. Z.; SchmauB, M.; Spitzer, C.; Wiltfang, J.; Zimmermann, J.; Fischer, A.; Falkai, P.; Schulze, T. G.; Heilbronner, U.; Poschmann, J.

10.1101/2025.03.28.645923 — immunology — Posted on 2025-05-28

860 Stimulus-Dependent Theta Rhythmic Activity in Primate V1 Predicts Visual Detection

Fanyiwi, P. T.; Agayby, B.; Kienitz, R.; Haag, M.; Cadena-Valencia, J.; Schmid, M. C.

10.1101/2021.11.30.470367 — neuroscience — Posted on 2025-05-28

861 Cell segmentation without annotation by unsupervised domain adaptation based on cooperative self-learning

Miyaki, S.; Morikura, T.; Nishimoto, S.; Tokuoka, Y.; Yamada, T. G.; Funahashi, A.

10.1101/2024.07.05.602197 — systems biology — Posted on 2025-05-28

862 Live-Exudation Assisted Phytobiome Cultromics System (LEAP-CS): A High-Throughput Cultromics System for Studying Plant-Microbiome Interactions through Non-Contact Metabolic Exchange.

Mazumder, M.; Pavagadhi, S.; Bhattacharya, R.; Mukherjee, A.; Majedi, S. M.; Tan, I. C. H.; Swarup, S.

10.1101/2025.05.07.652788 — plant biology — Posted on 2025-05-28

863 Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation

Sathe, G.; Roth, S.; Gelders, G.; Brewer, A.; Macartney, T.; Wood, N.; De Muynck, L.; Nakasone, M.; Phung, T.; Buist, A.; Moechars, D.; Sapkota, G. P.

10.1101/2025.05.27.656291 — cell biology — Posted on 2025-05-28

864 Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts

Gacha-Garay, M. J.; Liu, H.; Evans, S. E.; Mills, T.; Chen, J.

10.1101/2025.05.26.654588 — cell biology — Posted on 2025-05-28

865 Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter

Williamson, N. H.; Ravin, R.; Cai, T. X.; Rey, J. A.; Basser, P. J.

10.1101/2025.05.27.655493 — cell biology — Posted on 2025-05-28

866 Synergistic effects of proteinaceous pheromone and nitrogen starvation on male gametogenesis in the anisogamous volvocine alga Eudorina

Kawai-Toyooka, H.; Ono, M.; Hamaji, T.; Nozaki, H.; Hirono, M.

10.1101/2025.05.26.656211 — cell biology — Posted on 2025-05-28

867 Amino acid sensing by the α-cell mitochondrial phosphoenolpyruvate cycle regulates intracellular Ca2+ levels without impacting glucagon secretion

Jin, E.; Foster, H. R.; Potapenko, E.; Huang, S. M.; Dong, X.; Hughes, J. W.; Merrins, M. J.

10.1101/2025.05.26.656009 — cell biology — Posted on 2025-05-28

868 The Genetic and Evolutionary Landscape of Pentanucleotide Tandem Repeats in Human Genomes

Xu, I. R. L.; Pellerin, D.; Van De Vondel, L.; Danzi, M. C.; Zuchner, S.

10.1101/2025.05.27.656002 — genetics — Posted on 2025-05-27

869 Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits

Sacher, F.; Berki, B.; Fages, A.; Gavrilov, L.; Klar, A.; Luxey, M.; Tschopp, P.

10.1101/2025.05.26.656077 — developmental biology — Posted on 2025-05-27

870 Parallel and dynamic attention allocation during natural reading

Pan, Y.; Frisson, S.; Snell, J.; Federmeier, K. D.; Jensen, O.

10.1101/2025.05.27.656336 — neuroscience — Posted on 2025-05-27

871 Changes in social reward across adolescence in male mice

Harda, Z.; Klimczak, M.; Misiolek, K.; Chroszcz, M.; Szumiec, L.; Kaczmarczyk-Jarosz, M.; Rzeszut, A.; Rygula, R.; Ziolkowska, B.; Rodriguez Parkitna, J. M.

10.1101/2025.05.27.656363 — neuroscience — Posted on 2025-05-27

872 Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines

Frazier, S. E. D.; de Lichtenberg, K. H.; Jaberi, E.; Bertelsen, C.; Jensen, S. M.; Wrona, A.; Nielsen, F. M.; Christophersen, N. S.; Kristensen, M.; Villaescusa, J. C.

10.1101/2025.05.27.656305 — neuroscience — Posted on 2025-05-27

873 Focused ultrasound to the bilateral thalamus causally modulates human cognitive attention in a frequency- and intensity-dependent manner

Caulfield, K. A.; Sege, C. T.; Weaver, J.; Murphy, K. R.; Passaro, T.; Meads, K.; Dadgar-Kiani, E.; Antonucci, M. U.; Good, C.; McTeague, L. M.

10.1101/2025.05.27.656481 — neuroscience — Posted on 2025-05-27

874 System-wide dissociation of reward and aversive dopaminergic signals

Bouchard, S.-J.; Bouchard, J.; Levesque, M.; Breton-Provencher, V.

10.1101/2025.05.27.656467 — neuroscience — Posted on 2025-05-27

875 PerTurboAgent: A Self-Planning Agent for Boosting Sequential Perturb-seq Experiments

Hao, M.; Lee, Y.; Wang, H.; Scalia, G.; Regev, A.

10.1101/2025.05.25.656020 — bioinformatics — Posted on 2025-05-27

876 CHARON: Estimating the drift time and the number of individuals in environmental DNA with diploid individuals

van Waaij, J.; Hartmann, M. V.; Sackett, P. W.; Renaud, G.

10.1101/2025.05.26.656139 — evolutionary biology — Posted on 2025-05-27

877 Gene expression divergence following gene and genome duplications in spatially resolved plant transcriptomes

Almeida-Silva, F.; Van de Peer, Y.

10.1101/2025.05.27.656262 — evolutionary biology — Posted on 2025-05-27

878 The impact of background selection in mutation-selection-drift balance models of complex trait evolution

Li, X.; Berg, J. J.

10.1101/2025.05.27.656342 — evolutionary biology — Posted on 2025-05-27

879 Isolation and manipulation of meiotic spindles from mouse oocytes reveals migration regulated by pulling force during asymmetric division

Liu, N.; Kawamura, R.; Qiang, W.; Londono, D.; Balboula, A.; Marko, J. F.; Qiao, H.

10.1101/2024.12.06.627260 — cell biology — Posted on 2025-05-27

880 ECD functions as a novel RNA-binding protein to regulate mRNA splicing

Raza, M.; Rajan, A. R.; Kalluchi, A.; Saleem, I.; Kennedy, B. B.; Bhakat, K. K.; Band, H.; Rowley, M. J.; Band, V.

10.1101/2025.01.24.634785 — cell biology — Posted on 2025-05-27

881 Discovering Polyphosphate and Polyhydroxyalkanoate-Accumulating Organisms Across Ecosystems: Phenotype-targeted Genotyping via FACS-sequencing

Yan, Y.; Baldwin, M.; Lee, J.; Wang, Z.; Li, G.; Han, I.; He, P.; Shrinivasan, V.; Wicked-Do, L.; Gore, M.; Gu, A. Z.

10.1101/2025.03.24.644850 — microbiology — Posted on 2025-05-27

882 A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

Calle-Schuler, S. A.; Santana-Cruz, A. E.; Kmecova, L.; Hampel, S.; Seeds, A. M.

10.1101/2025.05.19.654894 — neuroscience — Posted on 2025-05-27

883 Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

Allavena, G.; Rossiello, F.; Idilli, A. I.; Mione, M.; di Fagagna, F. d.; Ferreira, M. G.; Lopes-Bastos, B.

10.1101/2025.05.23.655694 — pathology — Posted on 2025-05-27

884 Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis Imperfecta

Montagna, G.; Lee, S.; Baacke, A.; Warman, M.; Jacobsen, C. M.

10.1101/2025.05.27.656429 — genetics — Posted on 2025-05-27

885 Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in Histoplasma, a fungal pathogen of humans

Heater, S.; Voorhies, M.; Rodriguez, R. A.; English, B. C.; Sil, A.

10.1101/2025.05.23.655702 — genetics — Posted on 2025-05-27

886 Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps

Lovestam, S.; Scheres, S. H. W.

10.1101/2025.05.27.656403 — molecular biology — Posted on 2025-05-27

887 Modulation of archaeal hypernucleosome structure and stability by Mg2+

Zarguit, I.; Cajili, M. K.; van Erp, B.; Schwab, S.; van der Vis, N.; Bakker, M.; van Noort, J.; Dame, R. T.

10.1101/2025.05.26.656202 — molecular biology — Posted on 2025-05-27

888 NeuroConText: Contrastive Learning for Neuroscience Meta-Analysis with Rich Text Representation

Ghayem, F.; Meudec, R.; Dockes, J.; Thirion, B.; Wassermann, D.

10.1101/2025.05.23.655707 — neuroscience — Posted on 2025-05-27

889 Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosis

Gaule, T.; Simmons, K. J.; Walker, K.; Del Galdo, F.; Ross, R. L.; Viswambharan, H.; Krishnappa, J.; Pacey, J.; McPhillie, M.; Tomlinson, D. C.; Maqbool, A.

10.1101/2025.05.23.655116 — physiology — Posted on 2025-05-27

890 Beyond performance: How design choices shape chemical language models

Fender, I.; Gut, J. A.; Lemmin, T.

10.1101/2025.05.23.655735 — bioinformatics — Posted on 2025-05-27

891 A new heme enzyme family forms hydrazine groups in diverse biosynthetic pathways

Kenney, G. E.; Wang, K.-K. A.; Ng, T.; van der Donk, W.; Balskus, E. P.

10.1101/2025.05.27.656397 — biochemistry — Posted on 2025-05-27

892 Tracing the drivers of range-wide bowhead whale genomic structure and diversity

Westbury, M. V.; Freymueller, N. A.; Cabrera, A. A.; Bachmann, L.; Ferguson, S.; Heide-Jorgensen, M. P.; Kovacs, K. M.; Lydersen, C.; Shpak, O.; Wiig, O.; Fordham, D. A.; Lorenzen, E. D.

10.1101/2025.05.23.655713 — evolutionary biology — Posted on 2025-05-27

893 Beyond acute toxicity: evolutionary response by rapid polygenic adaptation to a complex environmental stressor in Chironomus riparius

Rigano, L.; Schmitz, M.; Hollert, H.; Pfenninger, M.

10.1101/2025.05.23.655730 — evolutionary biology — Posted on 2025-05-27

894 Structural basis of auxin binding and transport by Arabidopsis thaliana AUX1

Jing, D.; Kong, F.; Lu, X.; Huang, G.; Huang, J.; Wang, H.; Shi, Y.; Wang, C.

10.1101/2025.05.27.656222 — molecular biology — Posted on 2025-05-27

895 Comparative Transcriptomics Reveals Context- and Strain-Specific Regulatory Programs of Agrobacterium During Plant Colonization

Wu, Y.; Chang, H.-Y.; Wu, C.-H.; Lai, E.-M.; Kuo, C.-H.

10.1101/2025.05.27.656240 — microbiology — Posted on 2025-05-27

896 Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis

Dey, S.; Cao, J.-H.; Balluff, B.; Dey, N. S.; Gilbert, L.; James, S. R.; Dowle, A.; Calder, G.; O'Toole, P.; Heeren, R. M. A.; Kaye, P. M.

10.1101/2025.05.23.655708 — immunology — Posted on 2025-05-27

897 Correlations of neural predictability and information transfer in cortex and their relation to predictive coding

Fiorenza, J. P.; Le Donne, L.; Schmidt-Samoa, C.; Heide, E.- C.; von der Brelie, C.; Malinova, V.; Focke, N. K.; Wilke, M.; Melloni, L.; Schwiedrzik, C. M.; Wibral, M.

10.1101/2025.05.23.655705 — neuroscience — Posted on 2025-05-27

898 Platelet-dependent clearance of uropathogenic Escherichia coli directly drives sepsis-induced thrombocytopenia in a mouse model

Johnsen, N.; Christensen, M. G.; Sparsoe, L. V.; Lambertsen, E. H.; Corydon, T.; Praetorius, H.

10.1101/2025.05.23.655700 — physiology — Posted on 2025-05-27

899 Updated chromosome-level genome assembly of Sporisorium scitamineum with improved accuracy and completeness

Taniguti, L. M.; Vilanova, P. F.; Kitajima, J. P.; Monteiro-Vitorello, C. B.

10.1101/2025.05.23.649816 — bioinformatics — Posted on 2025-05-27

900 Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ

de Oliveira Silva, Y. R.; Barnes, G.; Zheng, D.; Zhitnitsky, D.; Geathers, S. J.; Peters, S. C.; Szalai, V. A.; Helmann, J. D.; Fisher, O. S.

10.1101/2025.05.23.655588 — biochemistry — Posted on 2025-05-27

901 Critical structural perturbations of ribozyme active sites induced by 2'-O-methylation commonly used in structural studies

Forget, S.; Stirnemann, G.

10.1101/2025.05.26.656154 — biochemistry — Posted on 2025-05-27

902 A flexible end-to-end automated sample preparation workflow enables reproducible large-scale bottom-up proteomics

Raess, L.; Schaer, S.; Malinovska, L.; Savickas, S.; Cavallo, F.; Below, C. R.; Tognetti, M.; Shichkova, P.; Gourdet, B.; Robles, G.; Iu, L.; Vowinckel, J.; Feng, Y.; Hjerpe, R.; Bruderer, R.; Reiter, L.

10.1101/2025.05.23.655690 — biochemistry — Posted on 2025-05-27

903 Comparative genomic analysis of Cluster AZ Arthrobacter phages

Freise, A. C.; Furlong, K. P.; Klyczek, K. K.; Beyer, A. R.; Chong, R. A.; Edgington, N. P.; Gibb, B. P.; Swerdlow, S. J.; Bendele, M. G.; Cobb, I. D.; Mitchell, Z. J.; Cresawn, S. G.; Garcia Costas, A. M.; Rudner, A. D.

10.1101/2025.05.26.655371 — genomics — Posted on 2025-05-27

904 Neurotranscriptomic profiling of DWV-infected honey bee foragers with different cognitive abilities

Loughran, S. E.; Manfredini, F.; Bowman, A. S.; Dingle, L.

10.1101/2025.05.23.655587 — genomics — Posted on 2025-05-27

905 Multimodal analysis of in vitro hematopoiesis reveals blood cell-specific genetic impacts on complex disease traits

Qiu, R.; Trang, K. B.; Shalaby, C.; Pippin, J.; Garifallou, J.; Grant, S. F.; Thom, C. S.

10.1101/2025.05.23.655825 — genetics — Posted on 2025-05-27

906 Climate associated natural selection in the human mitochondrial genome

Grover-Thomas, F.; van Dorp, L.; Balloux, F.; Andres, A. M.; Camus, M. F.

10.1101/2025.05.23.655374 — evolutionary biology — Posted on 2025-05-27

907 Metabarcoding reveals the effect of land cover and temporal variations on the diet of Brown long-eared and Soprano pipistrelle bats within a unique European habitat, the pasture dominated landscapes of Ireland.

Hurpy, G.; Aughney, T.; Skujina, I.; Roche, N.; Teeling, E. C.

10.1101/2025.05.23.655448 — ecology — Posted on 2025-05-27

908 Biodiversity State Indicator: Integrating taxonomy, functionality and species interactions

Mortensen, L. O.; Brodnicke, O. B.; Devantier, C. B.; Ferreira, S. A.; Wong, X. H.; Schrameyer, V.

10.1101/2025.05.23.655681 — ecology — Posted on 2025-05-27

909 Host-Specific Transcriptional Responses of Phytophthora capsici During Early Crown Infection in Cucurbitaceous and Solanaceous Plants

Vargas-Mejia, P.; Sanchez-Segura, L.; Rojas-Rojas, F. U.; Shimada-Beltran, H.; Vega-Arreguin, J. C.

10.1101/2025.05.26.656185 — molecular biology — Posted on 2025-05-27

910 Pathological meprin α expression associated with degradation of dermokine drives a psoriasis-like skin phenotype in a genetic mouse model

Köhling, V.; Peters, F.; Götting, I.; Fries, E.; Beck, N.; Armbrust, F.; Beckinger, S.; Bülck, C.; Canbay, V.; Harder, I.; Mengel, M.; Rüffer, M.; Bickenbach, K.; Kalogeropoulos, K.; Schweizer, M.; Schumacher, N.; Haase, M.; Naumann, R.; auf dem Keller, U.; Becker-Pauly, C.; Rüffer, S.

10.1101/2025.05.23.655724 — molecular biology — Posted on 2025-05-27

911 Structure of the conjugation surface exclusion protein TraT

Berks, B. C.; Chen, N.; Bukys, A.; Lundgren, C. A.; Deme, J. C.; El Sayyed, H.; Kapanidis, A. N.; Lea, S. M.

10.1101/2025.05.27.656304 — microbiology — Posted on 2025-05-27

912 Sedative choice alters Klebsiella pneumoniae lung pathogenesis and dissemination

Mains, D.; Rotman, E. R.; Aman, D. K.; Ludvik, D. A.; Desikan, A.; Kocher, A. A.; Mandel, M. J.; Freitag, N. E.

10.1101/2025.05.27.656367 — microbiology — Posted on 2025-05-27

913 Attenuation of IFITM proteins antiviral activity through sequestration into intraluminal vesicles of late endosomes

Melikyan, G. B.; Prikryl, D. B.; Zhang, Y.

10.1101/2025.05.27.656272 — microbiology — Posted on 2025-05-27

914 In vivo guanine quadruplex structure dynamics and role in genome maintenance in Deinococcus radiodurans

Tewari, H.; Mishra, S.; kota, S.

10.1101/2025.05.27.656347 — microbiology — Posted on 2025-05-27

915 Virus-mediated recycling of chemoautotrophic biomass

Luo, E.; Pham, N. D.; Rogers, T. J.; Vallino, J. J.; Benner, B. E.; Trubl, G.; Huber, J. A.

10.1101/2025.05.27.656380 — microbiology — Posted on 2025-05-27

916 Myeloid-specific TFAM deficiency drives mitochondrial DNA stress and exacerbates allergic airway inflammation

Nguyen, J.; Van, C.; Karpurapu, M.; Kim, J.; Lee, T. J.; Yoo, J. Y.; Pabla, N. S.; Christman, J.; Chung, S.

10.1101/2025.05.27.654580 — immunology — Posted on 2025-05-27

917 Stress-Induced Alteration of Small Extracellular Vesicles Drives Amyloid-Beta Sequestration and Exacerbates Alzheimer's Disease Pathogenesis

Kumar, S.; Zehra, S.; Rai, S.; Rani, K.; Choudhury, S. D.; Rai, H.; Bhowmik, S.; Mohan, N.; Gupta, A.; Chatterjee, P.; Reddy, T. J.; Rani, N.; Modi, G. P.; Nikolajeff, F.

10.1101/2025.05.23.655679 — neuroscience — Posted on 2025-05-27

918 Selective targeting of Plasmodium falciparum hexose transporter by phytochemical Ginsenoside Rg1 disrupts glucose metabolism and block development of parasite

Shafi, S.; Maurya, P.; Bansal, R.; Sharma, J.; Mishra, S. K.; Najmi, A. K.; Singh, S.

10.1101/2025.05.23.655744 — pharmacology and toxicology — Posted on 2025-05-27

919 Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID

Acharya, P.; Jacoby, D.

10.1101/2025.05.25.656018 — genomics — Posted on 2025-05-27

920 Bacterial Community Structure and Diversity of Common Mosquito Species in Chengdu: Insights from PacBio Third-Generation

Xing, Y.; Wenjia, T.; Wei, Z.; Zelin, L.; Rong, L.; Kai, X.; Shuangfeng, F.

10.1101/2025.05.27.656271 — microbiology — Posted on 2025-05-27

921 Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations.

Philips, E. A.; Alharithi, Y.; Wilson, T. D.; Broberg, C.; Davis, B. A.; Koch, S.; Carbone, L.; Rubinstein, J.; Gurley, S. B.; Rugonyi, S.; Kumar, S.; Maloyan, A.

10.1101/2025.04.15.648971 — molecular biology — Posted on 2025-05-27

922 Attention Modulates Stimulus Representations in Neural Feature Dimension Maps

Thayer, D. D.; Sprague, T. C.

10.1101/2025.01.10.632497 — neuroscience — Posted on 2025-05-27

923 A Biosynthetic Thumb Prosthesis

Bansal, S.; Lai, G. V.; Belingheri, M.; Kashay, A. Q.; Kim, J. K.; Tomkinson, A.; Herman, S.; Bollavaram, K.; Zukotynski, B. K.; Jain, N. S.; Azari, K. K.; Wessel, L. E.; Clites, T. R.

10.1101/2025.05.23.655850 — bioengineering — Posted on 2025-05-27

924 Biosynthesis of the alpha-D-Mannosidase Inhibitor (-)-Swainsonine

Liu, S.; Batool, Z.; Hai, Y.

10.1101/2024.09.26.615303 — biochemistry — Posted on 2025-05-27

925 Scaled multidimensional assays of variant effect identify sequence-function relationships in hypertrophic cardiomyopathy

Yamamoto, Y.; Chua, K.; Ferrasse, A.; Kirillova, A.; De Jong, H.; Floyd, B.; Cadisch, C.; Wiel, L.; Wang, Q.; O'Neill, M.; Tabet, D. R.; Staudt, D. W.; Gorzynski, J. E.; Huang, Y.; Wilson, R. H.; Sharma, A.; Tapales, A.; Agrawal, R.; Wheeler, M. T.; MacRae, C. A.; Roden, D. M.; Roth, F.; Glazer, A. M.; Ashley, E. A.; Parikh, V. N.

10.1101/2025.05.23.655878 — genetics — Posted on 2025-05-27

926 Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development

Peters, L. D.; Brusko, M. A.; Seay, H. R.; Posgai, A. L.; Wasserfall, C. H.; Atkinson, M. A.; Bacher, R.; Brusko, T. M.

10.1101/2025.05.23.655848 — immunology — Posted on 2025-05-27

927 Cell Painting in activated cells illuminates phenotypic dark space and uncovers novel drug mechanisms of action.

Zietek, M.; Lohith, A.; Terciano, D.; Rabbitts, B.; Khadilkar, A.; MacMillan, J.; Lokey, S.

10.1101/2025.05.23.655853 — systems biology — Posted on 2025-05-27

928 12 weeks of voluntary wheel running restores glucagon sensitivity in middle-aged mice

Marx, T. J.; Bruner, K. R.; Ghimire, S.; Fletcher, T.; Stern, J. H.

10.1101/2025.05.23.655872 — physiology — Posted on 2025-05-27

929 DeepEpitope: Leveraging Transformation-Based protein Embeddings for Accurate linear Cancer B-cell Epitope Identification

T, D.; Rao, P. V.; Vasudevan, K.

10.1101/2025.05.23.655884 — cancer biology — Posted on 2025-05-27

930 Alignment-driven Cross-Graph Modeling for 3D RNA Inverse Folding

Wang, S.; Shen, H.-B.; Pan, X.

10.1101/2025.05.23.655885 — bioinformatics — Posted on 2025-05-27

931 The evolution of pectate lyase-like genes across land plants, and their roles in haustorium formation in parasitic plant, Triphysaria versicolor (Orobanchaceae)

Zhang, H.; Wafula, E. K.; Kelly, E. M.; Ko, I.; Yocca, A.; Bandaranayake, P. C. G.; Yang, Z.; Steele, D. B.; Yoder, J.; Honaas, L.; dePamphilis, C.

10.1101/2024.12.04.626843 — plant biology — Posted on 2025-05-27

932 The Global Wheat Full Semantic Organ Segmentation (GWFSS) dataset

Wang, Z.; Zenkl, R.; Greche, L.; De Solan, B.; Bernigaud Samatan, L.; Ouahid, S.; Visioni, A.; Robles-Zazueta, C. A.; Pinto, F.; Perez-Olivera, I.; Reynolds, M. P.; Zhu, C.; Liu, S.; D'argaignon, M.-P.; Lopez-Lozano, R.; Weiss, M.; Marzougui, A.; Roth, L.; Dandrifosse, S.; Carlier, A.; Dumont, B.; Mercatoris, B.; Fernandez, J.; Chapman, S.; Najafian, K.; Stavness, I.; Wang, H.; Guo, W.; Virlet, N.; Hawkesford, M.; Chen, Z.; David, E.; Gillet, J.; Irfan, K.; Comar, A.; Hund, A.

10.1101/2025.03.18.642594 — plant biology — Posted on 2025-05-27

933 Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

Tsingos, E.; Dick, A. M.; Bajoghli, B.

10.1101/2024.06.25.600590 — cancer biology — Posted on 2025-05-27

934 Monitoring the Coating of Single DNA Origami Nanostructures with a Molecular Fluorescence Lifetime Sensor

Scheckenbach, M.; Brueggenthies, G. A.; Schroeder, T.; Betuker, K.; Wassermann, L. M.; Tinnefeld, P.; Heuer-Jungemann, A.; Glembockyte, V.

10.1101/2024.10.28.620667 — biophysics — Posted on 2025-05-27

935 3D Agent-based modeling without chemical signaling recreatescollective behaviors seen in Myxococcus xanthus colonies

Copenhagen, K.; Black, M.; Shaevitz, J. W.

10.1101/2025.05.23.655808 — biophysics — Posted on 2025-05-27

936 Direct observation of single intrinsically disordered proteins in solution

Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.

10.1101/2025.05.26.656162 — biophysics — Posted on 2025-05-27

937 Elevational and Oceanic Barriers Shape the Distribution, Dispersal and Diversity of Aotearoa's Kapokapowai (Uropetala) Dragonflies

Tolman, E. R.; Beatty, C. D.; Goodman, A. G.; Ramchand, P.; McAllister, T.; Reyes, K.; Zahara, A.; Taveras, K.; Wade, V.; Abbott, J.; Guralnick, R.; Harding, K. M.; Kohli, M. K.; Frandsen, P. B.; Ware, J. L.; Suvorov, A.

10.1101/2024.11.25.625207 — evolutionary biology — Posted on 2025-05-27

938 Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

Sergounioti, A.; Alonaris, E.; Rigas, D.

10.1101/2025.04.27.650828 — cell biology — Posted on 2025-05-27

939 Intravenous BCG immunization drives naive CD4+ T cell to Th1 differentiation via CD4+ T cell epigenetic reprogramming

Wang, R.; Zhao, Y.; Yang, J.; Luo, R.; Sun, W.; Zhang, M.; Xiang, D.; Hou, Y.; Cao, P.; Li, E.

10.1101/2025.05.23.655674 — immunology — Posted on 2025-05-27

940 The cellular and behavioral blueprints of chordate rheotaxis.

Tolstenkov, O.; Ozawa, A.; Allombert-Blaise, C.; Hoyer, J.; Hiraiwa, T.; Chatzigeorgiou, M.

10.1101/2025.03.22.644710 — neuroscience — Posted on 2025-05-27

941 Stimulus-modulated approach to steady-state: A new paradigm for event-related fMRI.

Mathew, R.; Eed, A.; Klassen, M.; Oran, O.; Everling, S.; Menon, R. S.

10.1101/2024.09.20.613944 — neuroscience — Posted on 2025-05-27

942 The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

Peukes, J.; Lovatt, M.; Leistner, C.; Boulanger, J.; Morado, D. R.; Fuller, M. J. G.; Kukulski, W.; Zhu, F.; Komiyama, N. H.; Briggs, J. A. G.; Grant, S. G. N.; Frank, R. A. W.

10.1101/2021.02.19.432002 — neuroscience — Posted on 2025-05-27

943 Promoting social connectedness through multi-person neurofeedback

Cheng, X.; Zhang, R.; Chen, P.; Song, Z.; Cheng, F.; Dikker, S.; Pan, Y.

10.1101/2025.05.22.655644 — neuroscience — Posted on 2025-05-27

944 Cellular and subcellular specialization enables biology-constrained deep learning

Galloni, A. R.; Peddada, A.; Chennawar, Y.; Milstein, A. D.

10.1101/2025.05.22.655599 — neuroscience — Posted on 2025-05-27

945 NeuroSC: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks

Koonce, N. L.; Emerson, S. E.; Bhaskar, D.; Kuchroo, M.; Moyle, M. W.; Arroyo-Morales, P.; Martinez, N. V.; Emerson, J. I.; Krishnaswamy, S.; Mohler, W.; Colon-Ramos, D.

10.1101/2024.08.27.609993 — neuroscience — Posted on 2025-05-27

946 Increased Postprandial Metabolic Flexibility is Associated with Higher Body Fat Percentages in Healthy Young Adults

Foreman, N. A.; Rajwade, S.; Bluth, J.; Skoglund, L.; Letts, A. M.; DiPietro, L.; Ciarleglio, A.; Barberio, M.

10.1101/2024.08.23.609405 — physiology — Posted on 2025-05-27

947 Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

Bhuiyan, P.; Yi, Y.; Wei, B.; Yan, A.; Dong, L.; Wei, H.

10.1101/2025.05.21.655232 — pharmacology and toxicology — Posted on 2025-05-27

948 WITHDRAWN: Cell based dATP delivery as a therapy for chronic heart failure.

Mhatre, K. N.; Mathieu, J.; Martinson, A.; Flint, G.; Blakley, L. P.; Tabesh, A.; Reinecke, H.; Yang, X.; Guan, X.; Murali, E.; Klaiman, J. M.; Odom, G. L.; Brown, M. B.; Tian, R.; Hauschka, S. D.; Raftery, D.; Moussavi-Harami, F.; Regnier, M.; Murry, C. E.

10.1101/2023.04.24.538108 — pathology — Posted on 2025-05-27

949 Coherent Structures in Active Flows on Dynamic Surfaces

Santhosh, S.; Zhu, C.; Fencil, B.; Serra, M.

10.1101/2025.05.23.655805 — biophysics — Posted on 2025-05-27

950 Spike Train Scalograms (STS): a Deep Learning Classification Pipeline for Neuronal Cell Types

Amprimo, G.; Martini, L.; Bilir, B.; Bardini, R.; Savino, A.; Olmo, G.; Di Carlo, S.

10.1101/2025.02.10.637424 — bioinformatics — Posted on 2025-05-27

951 Cardiac Fibroblasts regulate myocardium and coronary vasculature development via the collagen signaling pathway

Deng, Y.; He, Y.; Xu, J.; He, H.; Zhang, M.; Li, G.

10.1101/2024.09.11.612512 — developmental biology — Posted on 2025-05-27

952 Cardiac-phase gating of eye movements: evidence from a gaze-contingent "search-light" paradigm

Hisada, A.; Isomura, T.

10.1101/2025.05.23.655692 — physiology — Posted on 2025-05-27

953 Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells

Vivas, O.; Baudot, M.; Choi, S.; Flores, V. A.; Santana, L. F.; Moreno, C. M.

10.1101/2022.06.22.497267 — biophysics — Posted on 2025-05-27

954 Structure-function analysis of lithium-ion selectivity of voltage-gated sodium channel

Maeda, Y. K.; Kojima, K.; Nakamura, T. Y.; Nakatsu, T.; Irie, K.

10.1101/2025.05.26.656081 — biophysics — Posted on 2025-05-27

955 First full-genome alignment representative for the genus Pestivirus

Triebel, S.; Eulenfeld, T.; Ontiveros-Palacios, N.; Sweeney, B.; Tautz, N.; Marz, M.

10.1101/2025.05.22.655560 — bioinformatics — Posted on 2025-05-27

956 Fast and Accurate Draft Genome Patching with GPatch

Diehl, A.; Boyle, A. P.

10.1101/2025.05.22.655567 — genomics — Posted on 2025-05-27

957 Flight height patterns of a critically endangered insectivorous bat, impacted by wind turbine collision

Bush, A.; Lumsden, L.; Prowse, T. A. A.

10.1101/2025.05.23.655017 — ecology — Posted on 2025-05-27

958 Cellular metabolic state controls mitochondrial RNA kinetics

Reardon, S. D.; Bautista, C.; Cole, S. C.; Cicero, J.; Mishanina, T. V.

10.1101/2025.05.13.653903 — molecular biology — Posted on 2025-05-27

959 HIV-1 envelopes from virions that persist in plasma on antiretroviral therapy show reduced susceptibility to autologous immunoglobulins and variable sensitivity to broadly neutralizing monoclonal antibodies

Manhas, S.; Brooker, J. P.; Shetler, C.; Penrose, K. J.; Jaiswal, D. S.; Chu, X.; Li, W.; Kearney, M. F.; Mellors, J. W.; Halvas, E. K.

10.1101/2025.05.22.655427 — immunology — Posted on 2025-05-27

960 MACHINE LEARNING FOR MISSING DATA IMPUTATION IN ALZHEIMER'S RESEARCH: PREDICTING MEDIAL TEMPORAL LOBE FLEXIBILITY

Moallemian, S.; Saghafi, A.; Deshpande, R.; Perez, J. M.; Budak, M.; Fausto, B. A.; Elahi, F.; Gluck, M. A.

10.1101/2025.05.22.655574 — neuroscience — Posted on 2025-05-27

961 An information theory framework for capturing multi-connectivity via spatial network encoding reveals reduced population count (Hamming weight) localized to auditory, visual, and motor networks

Bostami, B.; Lewis, N.; Agcaoglu, O.; Silva, R. F.; Turner, J. A.; van Erp, T.; Ford, J.; Calhoun, V.

10.1101/2025.05.22.655511 — neuroscience — Posted on 2025-05-27

962 Chondrocyte-Specific Knockout of Piezo1 and Piezo2 Protects Against Post-Traumatic Osteoarthritis Structural Damage and Pain in Mice

Ely, E.; Lenz, K.; Paradi, S.; Ack, S.; Behrmann, A.; Dunivan, S.; Braxton, L.; Liedtke, W.; Chen, Y.; Collins, K. H.; Guilak, F.

10.1101/2025.05.22.655585 — physiology — Posted on 2025-05-27

963 Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia

Sharkey, C.; Gu, B.; Long, X.; Tang, Y.; Patsatzis, N.; Li, S.; Olumi, A. F.; wang, z.

10.1101/2025.05.22.655540 — pathology — Posted on 2025-05-27

964 JMod: Joint modeling of mass spectra for empowering multiplexed DIA proteomics

McDonnell, K.; Wamsley, N.; Derks, J.; Sipe, S.; Yeh, M.; Specht, H.; Slavov, N.

10.1101/2025.05.22.655512 — bioinformatics — Posted on 2025-05-27

965 Identifying Positional Orthologs by Linear Programming

Gafurov, A.; Swenson, K. M.

10.1101/2025.05.22.655535 — bioinformatics — Posted on 2025-05-27

966 Increasing mass spectrometry throughput using time-encoded sample multiplexing

Derks, J.; McDonnell, K.; Wamsley, N.; Stewart, P.; Yeh, M.; Specht, H.; Slavov, N.

10.1101/2025.05.22.655515 — bioengineering — Posted on 2025-05-27

967 PSMtags improve peptide sequencing and throughput in sensitive proteomics

Specht, H.; Yeh, M.; Sipe, S.; Barnes-Seeman, D.; Adamo, M.; McDonnell, K.; Agius, M. P.; Friedrich, C.; Pang, W. K.; Huang, Y.; Shiva Raju, K.; Vuong, W.; Lee, M. A.; Yesilcimen, A.; Pentelute, B. L.; Slavov, N.

10.1101/2025.05.22.655509 — bioengineering — Posted on 2025-05-27

968 Hyperglycemic state and fluid shear stress affect metastatic breast cancer cell migration via focal adhesion kinase

Riehl, B. D.; Kim, E.; Boudreaux, T.; Ovando, O.; Vielmas-Duarte, S.; Choi, S.; Band, H.; Mei, L.; Dutta, D.; Chandra, S.; Lim, J. Y.

10.1101/2025.05.22.655615 — bioengineering — Posted on 2025-05-27

969 Synchronization of the collective air-breathing behavior in juvenile Arapaima gigas

Bartashevich, P.; Francisco, F. A.; Escurra-Alegre, A.; Schaefer, F.; Wuertz, S.; Krause, J.; Kloas, W.; Bierbach, D.

10.1101/2025.05.22.655545 — animal behavior and cognition — Posted on 2025-05-27

970 Comprehensive detection of structural variations in long and short reads dataset of French cattle

Naji, M. M.; Klopp, C.; Faraut, T.; Eche, C.; Di Franco, A.; Birbes, C.; Marcuzzo, C.; Suin, A.; Iampietro, C.; Kuchly, C.; Vernette, C.; Fritz, S.; Grohs, C.; Gaspin, C.; Milan, D.; Donnadieu, C.; Boichard, D.; Sanchez, M.-P.; Boussaha, M.

10.1101/2025.05.22.654398 — genomics — Posted on 2025-05-27

971 Biogeography shapes the TE landscape of Drosophila melanogaster

Pianezza, R.; Kofler, R.

10.1101/2025.05.22.655554 — genomics — Posted on 2025-05-27

972 Coevolutionary cycling in allele frequencies and the evolution of virulence

Kim, Y. S.; Ashby, B.

10.1101/2025.05.22.655598 — evolutionary biology — Posted on 2025-05-27

973 Reduced offspring viability is associated with long-term stability of a narrow avian hybrid zone

Long, K. M.; Braun, M. J.; Abrego, A. M.; Jaramillo, O.; Brawn, J. D.

10.1101/2025.05.22.655562 — evolutionary biology — Posted on 2025-05-27

974 Accumulation of a biparentally-inherited Neptune transposable element in natural Killifish hybrids (Fundulus diaphanus X F. heteroclitus)

Roussel, A.-J.; Suh, A.; Ruiz-Ruano, F. J.; Dion-Cote, A.-M.

10.1101/2025.05.22.655539 — evolutionary biology — Posted on 2025-05-27

975 LMO2 regulates epithelial-mesenchymal plasticity of mammary epithelial cells

Sikandar, S. S.; Haro-Acosta, V.; Juarez, M. A.; Olander, A.; Fetter, I. J.

10.1101/2025.05.22.655436 — developmental biology — Posted on 2025-05-27

976 Patterning defects in mice with defective ventricular wall maturation and cardiomyopathy

Santos-cantador, J.; Siguero-Alvarez, M.; de la Pompa, J. L.

10.1101/2025.05.22.655570 — developmental biology — Posted on 2025-05-27

977 CreER activation transiently impairs angiogenesis by slowing endothelial proliferation

Ioannou, E.; Dong, M.; Rashbrook, V. S.; Ruhrberg, C.; Rudnicki, M.

10.1101/2025.05.22.655564 — developmental biology — Posted on 2025-05-27

978 METTL3 regulates exocytosis independently of m6A

Esteva-Socias, M.; Bhattarai, D. P.; Achour, C.; Baidya, P.; Fontanari, G.; Seier, K.; Pace, H.; Malla, S.; Zhu, S.; Lundin, E.; Vagbo, C. B.; Bally, M.; Swaminathan, V. S.; Mateus, A.; Rodriguez-Barrueco, R.; Pich, A.; Aguilo, F.

10.1101/2025.05.26.656168 — molecular biology — Posted on 2025-05-27

979 Differential age effects on functional network development link to contextual memory disruption in APOE4 versus APOE3 homozygous mice

Simon, Z. D.; McFarland, K. N.; Chakrabarty, P.; Febo, M.

10.1101/2025.05.22.655620 — neuroscience — Posted on 2025-05-27

980 Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease

D'Addario, S. L.; Massaro Cenere, M.; Cossa, F.; Scaricamazza, S.; Nesci, V.; D'Ottavio, G.; Caprioli, D.; Ferri, A.; Vila, M.; Ledonne, A.; Mercuri, N. B.

10.1101/2025.04.18.649338 — neuroscience — Posted on 2025-05-27

981 Combining cortical and spinal stimulation maximizes improvement of gait after spinal cord injury

Drainville, R.; Bonizzato, M.; Burchielli, D.; Guay-Hottin, R.; Sheasby, A.; Martinez, M.

10.1101/2025.05.22.655593 — neuroscience — Posted on 2025-05-27

982 Epigenetic modifiers to treat retinal degenerative diseases

Popova, E.; Schneper, L.; Sebastian, A.; Albert, I.; Tombran-Tink, J.; Barnstable, C.

10.1101/2025.05.22.655558 — neuroscience — Posted on 2025-05-27

983 Age-related changes in proprioception are of limited size, outcome-dependent and task-dependent.

Van De Plas, S.; Orban de Xivry, J.-J.

10.1101/2025.05.22.655043 — neuroscience — Posted on 2025-05-27

984 Mechanism and energetics of JDP induced Hsp70's conformational transition towards catalytically active state

Olewniczak, M.; Pitek, M.; Czub, J.; Marszalek, J.; Nierzwicki, L.; Tomiczek, B.

10.1101/2025.05.22.655504 — biophysics — Posted on 2025-05-27

985 Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models

Raju, A.; Sharma, S.; Riley, B. T.; Djuraev, S.; Tan, Y.; Kim, M.; Mahmud, T.; Keedy, D. A.

10.1101/2025.05.23.655529 — biophysics — Posted on 2025-05-27

986 Advancing the Discovery of Phage-Host Interactions and Disease Classification from Metagenomic Profiles Using Deep Learning

Yang, Y.; Wang, T.; Huang, D.; Wang, X.-W.; Weiss, S. T.; Korzenik, J.; Liu, Y.-Y.

10.1101/2025.05.26.656232 — bioinformatics — Posted on 2025-05-27

987 FoldBench: An All-atom Benchmark for Biomolecular Structure Prediction

Xu, S.; Feng, Q.; Qiao, L.; Wu, H.; Shen, T.; Cheng, Y.; Zheng, S.; Sun, S.

10.1101/2025.05.22.655600 — bioinformatics — Posted on 2025-05-27

988 Offspring effect of maternal preconception exposure to metabolic disruptors

Diaz-Castillo, C.; Aguiar, S. R.; Chamorro-Garcia, R.

10.1101/2025.05.22.655630 — genomics — Posted on 2025-05-27

989 Recognition of pathogenic bacteria by intestinal progenitors promotes adult Drosophila midgut regeneration via PGRP-MKK3-p38 signalling.

Patel, P. H.; Uttekar, B.; Wafer, R.; Cendanawati, S.

10.1101/2025.05.22.655543 — developmental biology — Posted on 2025-05-27

990 Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors

Schippel, N.; Wei, J.; Ma, X.; Kala, M.; Qiu, S.; Stoilov, P.; Sharma, S.

10.1101/2024.08.29.610192 — developmental biology — Posted on 2025-05-27

991 PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

Sarkar, B.; Singh, J.; Yadav, M.; Sharma, P.; Sharma, R. D.; Singh, S.; Chandramouli, A.; Mehdiratta, K.; Kumar, A.; Kamat, S. S.; Ghorpade, D. S.; Mohanty, D.; Kumar, D.; Gokhale, R. S.

10.1101/2024.02.02.578554 — microbiology — Posted on 2025-05-27

992 Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

Hope, J. L.; Zhang, Y.; Hetrick, H. A. F.; Sanchez-Hernandez, E. S.; Silvestri, B.; Smith, B. J.; Nakil, S. H.; Roy, S.; Lin, M.; Palete, A. B.; Maganti, S.; Ling, L.; Otero, D. C.; Byrne, K.; Romano, G.; Wang, Y. X.; Commisso, C.; Bradley, L. M.

10.1101/2025.05.22.655365 — immunology — Posted on 2025-05-27

993 Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence

Rubinic, M.; Arias-Rojas, A.; Martinez, K. A.; Klimek, W.; Paczia, N.; Alagesan, K.; Duneau, D.; Iatsenko, I.

10.1101/2025.05.22.655590 — immunology — Posted on 2025-05-27

994 Cellular and subcellular specialization enables biology-constrained deep learning

Galloni, A. R.; Peddada, A.; Chennawar, Y.; Milstein, A. D.

10.1101/2025.05.22.655599 — neuroscience — Posted on 2025-05-27

995 Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons

Porniece, M.; Baker, J.; Ausfahl, C. D.; Zhang, S. X.; Andermann, M. L.

10.1101/2025.05.22.655553 — neuroscience — Posted on 2025-05-27

996 Predictive remapping and allocentric coding as consequences of energy efficiency in recurrent neural network models of active vision

Nortmann, T.; Sulewski, P.; Kietzmann, T. C.

10.1101/2025.05.22.655555 — neuroscience — Posted on 2025-05-27

997 Propagation of Beta bursts from the motor cortex to the motor units of multiple upper-limb muscles

Graef, C.; Valdunciel, A. P.; Farina, D.; Vaidyanathan, R.; Tai, Y. F.; Haar, S.

10.1101/2025.05.22.655541 — neuroscience — Posted on 2025-05-27

998 A complete suite for compact programming of protein secretion

Vlahos, A. E.; Call, C. C.; Eckman, N.; Kadaba, S. E.; Guo, S.; Thurm, A. R.; Kang, J.; Appel, E.; Bintu, L.; Gao, X. J.

10.1101/2023.10.04.560774 — synthetic biology — Posted on 2025-05-27

999 Beyond binding motif: genomic context predicts transcription factor dependent regulation in Arabidopsis

Turchi, L.; Lucas, J.; Tichtinsky, G.; Thierry-Mieg, N.; Blanc-Mathieu, R.; Parcy, F.; Frenoy, A.

10.1101/2025.05.23.655699 — plant biology — Posted on 2025-05-27

1000 Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice

Park-sigal, J. J.; Norton, M.; Tu, C.-L.; Cheng, Z.; Fadahunsi, N.; Lee, H.; Kim, S.; Li, A.; Grinberg, L. T.; Bewick, G. A.; Murphy, K. G.; Chang, W. A.

10.1101/2025.05.22.655605 — physiology — Posted on 2025-05-27

1001 Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Cassell, S. J.; Li, W.; Krautwald, S.; Khoshouei, M.; Lee, Y. T.; Hou, J.; Guan, W.; Peukert, S.; Weihofen, W.; Whicher, J.

10.1101/2025.05.22.655589 — pharmacology and toxicology — Posted on 2025-05-27

1002 Lipid gating of BK channels and mechanism of activation by negatively charged lipids

Mironenko, A.; de Groot, B. L.; Kopec, W.

10.1101/2025.05.27.656279 — biophysics — Posted on 2025-05-27

1003 Intrinsically disordered regions facilitate Msn2 target search to drive promoter selectivity

Strugo, N.; Burstein, C.; Hossain, S. S.; Nago, N.; Khamis, H.; Kaplan, A.

10.1101/2025.05.23.654710 — biophysics — Posted on 2025-05-27

1004 Multiscale Segmentation using Hierarchical Phase-contrast Tomography and Deep Learning

Zhou, Y.; Aslani, S.; Javanmardi, Y.; Brunet, J.; Stansby, D.; Carroll, S.; Bellier, A.; Ackermann, M.; Tafforeau, P.; Lee, P. D.; Walsh, C. L.

10.1101/2025.05.15.654263 — bioinformatics — Posted on 2025-05-27

1005 Database for extended ligand-target analyses (DELTA): a new balanced resource for AI applications in drug discovery

Pisati, A.; Pozzi, A.; Giuntini, F.; Pedretti, A.; Vistoli, G.

10.1101/2025.05.22.655476 — bioinformatics — Posted on 2025-05-27

1006 Elevated carbon dioxide stimulates highly efficient organic-carbon consumption and confectionary-waste valorization under mixotrophy in the unicellular alga Galdieria

Masson, M. L. P.; de Freitas, B. B.; Zybinskii, A.; Althagafi, G.; Amad, M.; Fox, M. D.; Lammers, P. J.; Lauersen, K. J.

10.1101/2025.05.22.655468 — bioengineering — Posted on 2025-05-27

1007 CRISPR activation screens map the genomic landscape of cancer glycome remodeling

Daly, J.; Piatnitca, L.; Al-Seragi, M.; Krishnamoorthy, V.; Wisnovsky, S.

10.1101/2025.05.26.656133 — genomics — Posted on 2025-05-27

1008 Quantifying Conformational Heterogeneity of 3D Genome Organization in Fruit Fly

Mali, S.; Tolokh, I. S.; Cross, E.; Onufriev, A. V.

10.1101/2025.05.24.655945 — genomics — Posted on 2025-05-27

1009 Multivariate Analysis for Agro-Morphological and Quality Traits in Groundnut (Arachis hypogaea L.) Genotypes in Eastern Ethiopia

Dama, D. B.

10.1101/2025.05.22.655537 — genetics — Posted on 2025-05-27

1010 Gene expression reveals the pancreas of Aselli as a critical organ for plasma cell differentiation in the common shrew

Thomas, W. R.; Baldoni, C.; Lama, T. M.; Zeng, Y.; Corthals, A. P.; von Elverfeldt, D.; Nieland, J.; Dechmann, D. K. N.; Davalos, L.

10.1101/2025.05.22.654563 — evolutionary biology — Posted on 2025-05-27

1011 Fish remain high in selenium long after mountaintop coal mines close

Cooke, C.; Graydon, J.; Luek, A.; Lu, X.; Yu, H.; Le, X. C.; Reichert, M.

10.1101/2025.05.22.655156 — ecology — Posted on 2025-05-27

1012 Natal philopatry, dispersal and age of first breeding in relation to size and sex of Arctic Terns Sterna paradisaea

Redfern, C. P.; Steel, D.; Morrison, P. G.

10.1101/2025.05.22.655618 — ecology — Posted on 2025-05-27

1013 A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets

Fye, M. A.; Sharma, R.; Myat, P. S. M.; Regan, P.; McKinney, H.; Gu, G.; Kaverina, I.

10.1101/2025.04.22.650066 — cell biology — Posted on 2025-05-27

1014 Carbon metabolism shapes FtsZ levels and cell division in a cyanobacterium

Ran, W.-S.; Zeng, X.; Zhang, C.-C.

10.1101/2025.05.26.656067 — microbiology — Posted on 2025-05-27

1015 Effect of Age on Xenobiotic-Induced Autoimmunity

de Ocampo, C.; Peiss, A. K.; Leung, H. Y.; Janssen, L. M.; Kono, D. H.; Mayeux, J. M.; Pollard, K. M.

10.1101/2025.05.22.655368 — immunology — Posted on 2025-05-27

1016 Stimulus-modulated approach to steady-state: A new paradigm for event-related fMRI.

Mathew, R.; Eed, A.; Klassen, M.; Oran, O.; Everling, S.; Menon, R. S.

10.1101/2024.09.20.613944 — neuroscience — Posted on 2025-05-27

1017 TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization

Nada, H.; El Gaamouch, F.; Cho, S.; Kuncewicz, K.; Calvo-Barreiro, L.; Gabr, M.

10.1101/2025.05.22.655617 — neuroscience — Posted on 2025-05-27

1018 Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Lopez Rodriguez, D.; Pamies, D.; Boccard, J.; Meister, I.; Galmiche, M.; Sajic, T.; Maret, E.; Heritier, N.; Frangiamone, M.; Thomas, A.; Hopf, N.; Rudaz, S.; Zurich, M.-G.

10.1101/2025.05.22.655411 — pharmacology and toxicology — Posted on 2025-05-27

1019 Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

Villarreal, E. S.; Marinho, Y.; Loya, O.; Aboagye, S. Y.; Williams, D. L.; Sun, J.; Erzurum, S.; de Jesus Perez, V.; Oliveira, S. D.

10.1101/2025.05.22.655387 — pharmacology and toxicology — Posted on 2025-05-27

1020 Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters

Roth, J.; Guo, H.; Chen, L.; Shen, M.; Gbadegesin, O.; Robey, R. W.; Gottesman, M. M.; Hall, M. D.

10.1101/2025.05.22.651305 — pharmacology and toxicology — Posted on 2025-05-27

1021 AlliGator: Open Source Fluorescence Lifetime Imaging Analysis in G

Michalet, X.

10.1101/2025.05.22.655640 — biophysics — Posted on 2025-05-27

1022 Movi Color: fast and accurate long-read classification with the move structure

Tan, S.; Majidian, S.; Langmead, B.; Zakeri, M.

10.1101/2025.05.22.655637 — bioinformatics — Posted on 2025-05-27

1023 A resource and computational approach for quantifying gene editing allelism at single-cell resolution

Ung, M. H.; Angelini, G.; Wang, R.; Pyclik, A.; Lydeard, J.; Ferrucio, J.; Lin, M.; Ge, H. G.

10.1101/2025.05.22.653824 — bioinformatics — Posted on 2025-05-27

1024 Modulating Hydrogel Stiffness Through Light-Based 3D Printing to Mimic Cardiac Fibrosis and Cardiomyocyte Dysfunction Using hiPSC-Derived Cells

Sohn, S.; Momtahan, N.; Stevens, L. M.; Han, J.; Liu, Y.; Kiker, M. T.; Recker, E. A.; Page, Z. A.; Zoldan, J.

10.1101/2025.05.20.655137 — bioengineering — Posted on 2025-05-27

1025 Bone Mineralization and Metabolism are Altered in a Rat Model of Brachial Plexus Birth Injury

Fawcett, E. B.; Potts, J. R.; Dixit, N. N.; Saul, K. R.; Cole, J. H.

10.1101/2025.05.22.655603 — bioengineering — Posted on 2025-05-27

1026 PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization

Harold, K. M.; Matsuzaki, S.; Pranay, A.; Zhu, J.; Faakye, A.; Humphries, K. M.

10.1101/2025.05.26.656235 — biochemistry — Posted on 2025-05-27

1027 Design to Data for mutants of β-glucosidase B from Paenibacillus polymyxa: L336M, L336A, L336S, L336H, D35E, D35W

Huntington, C.; Vater, A.; Siegel, J.

10.1101/2025.05.22.655130 — biochemistry — Posted on 2025-05-27

1028 Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age

Woo, Q. Y.; Lee, B. T. K.; Lim, L. W.; Zhang, J.; Tashiro, A.; Lau, P. K.; Thibault, G.; Wang, Y.; Lin, V. C. L.

10.1101/2025.05.22.655437 — animal behavior and cognition — Posted on 2025-05-27

1029 Metaproteomics revealing cyanide bioremediators in effluents from artisanal cassava processing in the Brazilian Amazon

Maciel, A. C.; NAHON, S. M. R.; COSTA, I. R. C. d.; Valadares, R.; PHILIPPSEN, H. K.; BAHULE, C. E.; CHAUQUE, B. J. M.; GUIMARAES, K. H. A.; ARAUJO, N. M. P.; LOPES, A. S.; Maciel, A.

10.1101/2025.05.20.655124 — genomics — Posted on 2025-05-27

1030 Variant Set Distillation

Christ, R.; Kang, C. J.; Aslett, L.; Lam, D.; Savitski, M. F.; Stitziel, N. O.; Steinsaltz, D.; Hall, I.

10.1101/2024.12.06.627210 — genomics — Posted on 2025-05-27

1031 Reproductive isolation due to divergent ecological selection is accompanied by vast genomic instability in experimentally evolved yeast populations

Bendixsen, D. P.; Gilchrist, C.; Haberkorn, C.; Persson, K.; Geijer, C.; Warringer, J.; Stelkens, R.

10.1101/2025.01.28.635359 — evolutionary biology — Posted on 2025-05-27

1032 Long-term surveillance suggests multiple hybridization events by nuclear reassortment and accelerated intercontinental spread of wheat yellow rust

Hovmoeller, M. S.; Thach, T.; Algaba, J. R.; Hansen, J. G.; Meyer, M.; Hodson, D.; Nazari, K.; Park, R. R.; Tamm, R.; Moeller, M.; Schwessinger, B.; Rathjen, J. P.; Silva, P.; Riella, V.; Justesen, A. F.

10.1101/2025.05.22.655633 — evolutionary biology — Posted on 2025-05-27

1033 Adapting a gas chromatograph for use as a testing chamber for thermal ecology experiments

Zilnik, G.; Casey, M. T.; Merten, P. V.; Machtley, S.; Hagler, J. R.

10.1101/2025.05.22.655604 — ecology — Posted on 2025-05-27

1034 Serum-free differentiation platform for the generation of B lymphocytes and natural killer cells from human CD34+ cord blood progenitors

Bhave, R.; Kath, C.-J.; Ruechel, N.; Vasileiou, E.; Jepsen, V. H.; Raba, K.; Pandyra, A. A.; Fischer, U.; Kogler, G.

10.1101/2025.05.22.655473 — developmental biology — Posted on 2025-05-27

1035 A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome

Deng, K.; Wang, Y.; Mic, J. C.; Liu, X.; Myers, G.; Yu, L.; Hammoud, S.; Adam, A.; Saba, R.; Natogi, V.; Drysdale, C.; Chen, B.; Ueharu, H.; Yee, J. L.; Kitzman, J.; Lyssiotis, C. A.; Mishina, Y.; Jones, M.; Kaartinen, V.; Guan, Y.; Khoriaty, R.; Engel, J. D.; Singh, S. A.

10.1101/2025.05.22.654334 — developmental biology — Posted on 2025-05-27

1036 Immune-Epithelial Interactions via TGF-β Orchestrates Stem-Cell Niche Formation and Morphogenesis

Traugh, N.; Trepicchio, C.; Rauner, G.; Parrish, M.; Kuperwasser, C.

10.1101/2025.05.22.655596 — developmental biology — Posted on 2025-05-27

1037 Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation

Jansen, M.; Strub, J.-M.; Chaloin, L.; Coopman, P.; Beaumelle, B.

10.1101/2025.05.26.656092 — cell biology — Posted on 2025-05-27

1038 Postpartum cytokine shifts and IL-10-mediated immune suppression in malaria-infected primigravid women

TRAORE, O.; Rouamba, T.; Zango, S. H.; Sorgho, H.; Valea, I.; Traore-Coulibaly, M.; Schallig, H. D. F. H.; Tinto, H.

10.1101/2025.05.21.655391 — immunology — Posted on 2025-05-27

1039 Crystalline silica exposure induces multiple systemic autoimmune phenotypes including inflammatory arthritis and nephritis in Collaborative Cross mice with differing sub-clinical autoimmune profiles.

Janssen, L. M.; de Ocampo, C.; Kono, D. H.; Hoet, P. H. M.; Pollard, K. M.; Mayeux, J. M.

10.1101/2025.05.22.655650 — immunology — Posted on 2025-05-27

1040 A Python Toolbox for Representational Similarity Analysis

van den Bosch, J. J.; Golan, T.; Peters, B.; Taylor, J.; Shahbazi, M.; Lin, B.; Charest, I.; Diedrichsen, J.; Kriegeskorte, N.; Mur, M.; Schuett, H.

10.1101/2025.05.22.655542 — neuroscience — Posted on 2025-05-27

1041 Effects of bilateral and unilateral mental practice on actual motor performance and event-related desynchronization

Umeno, K.; Itaguchi, Y.

10.1101/2025.05.22.655524 — neuroscience — Posted on 2025-05-27

1042 Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila

Yamakoshi, H.; Horigome, M.; Yamamoto, S.; Iwanami, S.; Iwami, S.; Tanaka, R.; Ishikawa, Y.; Kamikouchi, A.

10.1101/2025.05.22.655009 — neuroscience — Posted on 2025-05-27

1043 Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans

Zarodniuk, M.; Wenninger, A.; Najera, J.; Lee, J.; Markillie, J.; MacKenzie, C.; Bergqvist-Patzke, J.; Batista, B.; Panchbhavi, M.; Rumbach, R. n.; Burchett, A.; Datta, M.; Patzke, C.

10.1101/2025.05.22.655651 — neuroscience — Posted on 2025-05-27

1044 Improved Anisotropic Network Models for Membrane Protein Dynamics and Mechanosensitive Ion Channels

Han, Z.; Wang, L.; Song, C.

10.1101/2025.05.22.654704 — biophysics — Posted on 2025-05-27

1045 Head-related transfer function predictions reveal dominant sound transmission mechanisms in a dolphin head

Cheong, Y.; Ruesch, A.; Schalles, M.; Kainerstorfer, J.; Shinn-Cunningham, B. G.; Lee, W.-J.

10.1101/2025.05.22.655550 — biophysics — Posted on 2025-05-27

1046 Putting a lid on it: The N-terminal helix of Arf1 inhibits switching via uniform stabilization of the native state

Peters, E. V. A.; Koduru, T.; Hantman, N. A.; McCallum, S. A.; Huang, Q.; Cherfils, J.; Royer, C. A.

10.1101/2025.04.22.650101 — biophysics — Posted on 2025-05-27

1047 Deep Learning-Based Methods for Automated Estimation of Insect Length, Volume, and Biomass

Shirali, H.; Ascenzi, A.; Wuehrl, L.; Beyer, N.; DI LORENZO, N.; VACCARELLA, E.; KLUG, N.; MEIER, R.; CERRETTI, P.; Pylatiuk, C.

10.1101/2025.05.22.655251 — bioinformatics — Posted on 2025-05-27

1048 Deep Learning for Predicting Stem Cell Efficiency for use in Beta Cell Differentiation

Schoeb, F. J.; Binder, A.; Zamarian, V.; Sordi, V.; Scholz, H.; Malthe-Sorenssen, A.; Dysthe, D. K.

10.1101/2025.05.22.652867 — bioinformatics — Posted on 2025-05-27

1049 Engineering Large-Scale and Innervated Functional Human Gut for Transplantation

Poling, H. M.; Noel, T.; Singh, A.; Fisher, G. W.; Thorner, K.; Chaturvedi, P.; Nattamai, K.; Srivastava, K.; Batie, M. R.; Hausfeld, T.; Pitstick, A. L.; Brown, N. E.; MENORET, S.; Anegon, I.; Barrile, R.; Mayhew, C. N.; Takebe, T.; Wells, J. M.; Helmrath, M. A.; Mahe, M. M.

10.1101/2025.05.22.655510 — bioengineering — Posted on 2025-05-27

1050 A checklist of alien taxa for South Africa

Zengeya, T. A.; Faulkner, K. T.; Mtileni, M. M.; Winzer, L. L. F.; Kumschick, S.; McCulloch-Jones, E. J.; Miza-Tshangana, S. A.; Robinson, T. B.; Sifuba, A.; Engelbrecht, W.; van Wilgen, B. W.; Wilson, J. R.

10.1101/2025.05.22.655507 — ecology — Posted on 2025-05-27

1051 Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages

Fountain, A.; Mansat, M.; Lackraj, T.; Gimenez, M. C.; Moussaoui, S.; Ezzo, M.; Soffiaturo, S.; Urdaneta, E.; Verdawala, M. B.; Fung, K.; Lancaster, C.; Somerville, E.; Hinz, B.; Terebiznik, M.; Botelho, R. J.

10.1101/2024.07.31.605905 — cell biology — Posted on 2025-05-27

1052 Quantification of grapevine yield losses as a function downy mildew severity on foliage and cluster

Fabre, F.; Delbac, L.; Poeydebat, C.; Zaffaroni, M.

10.1101/2024.02.28.582447 — microbiology — Posted on 2025-05-27

1053 PDCD1 expression increases at elevated temperatures.

Toma-Jonik, A.; Janus, P.; Mrowiec, K.; Vydra, N.; Sarkowicz, K.; Bar, M.; Mirek, J.; Olbryt, M.; Fidyk, W.; Widlak, W.

10.1101/2025.05.22.652424 — immunology — Posted on 2025-05-27

1054 An algorithm to model the non-random connectome of cortical circuitry

Reimann, M. W.; Egas Santander, D.

10.1101/2025.05.22.655546 — neuroscience — Posted on 2025-05-27

1055 Node persistence from topological data analysis reveals changes in brain functional connectivity

Mondal, M.; Yadav, Y.; Jost, J.; Samal, A.

10.1101/2025.05.23.655816 — neuroscience — Posted on 2025-05-27

1056 Are Solid Particles Ready for Prime-Time Proteomics?

Kitano, E.; Demyanenko, Y.; Mohammed, S.

10.1101/2025.05.22.655475 — systems biology — Posted on 2025-05-27

1057 metagRoot: A comprehensive database of protein families associated with plant root microbiomes

Chasapi, M. N.; Chasapi, I. N.; Aplakidou, E.; Baltoumas, F. A.; Karatzas, E.; Iliopoulos, I.; Stravopodis, D. J.; Emiris, I. Z.; Buluc, A.; Georgakopoulos Soares, I.; Kyrpides, N.; Pavlopoulos, G. A.

10.1101/2025.05.22.653656 — bioinformatics — Posted on 2025-05-27

1058 OPTRACE: Optical Imaging Guided Transplantation and Tracking of Cells in the Mouse Brain

Wang, J.; Russell, C.; Walczak, M.; Gao, D.; Qiao, G.; Fan, X.; Chu, C.; Janowski, M.; Walczak, P.; Liang, Y.

10.1101/2025.05.24.655973 — bioengineering — Posted on 2025-05-27

1059 Complex compositional and functional diversity of venom metalloproteinases in African puff adders

Wilkinson, M. C.; Modahl, C.; Saviola, A.; Albulesco, L.-O.; Tianyi, F.-L.; Harrison, R. A.; Casewell, N. R.

10.1101/2024.05.31.596867 — biochemistry — Posted on 2025-05-27

1060 Comparative genomics of Rickettsiella bacteria reveal variable metabolic pathways potentially involved in symbiotic interactions with arthropods

Floriano, A. M. M.; El-Filali, A.; Amoros, J.; Buysse, M.; Jourdan-Pineau, H.; Sprong, H.; Kohl, R.; Dirks, R. P.; Schaap, P.; Koehorst, J.; Nijsse, B.; Bouchon, D.; Daubin, V.; Vavre, F.; Duron, O.

10.1101/2024.12.03.626579 — evolutionary biology — Posted on 2025-05-27

1061 The evolution of host exploitation by parasitoid wasps: the timing of attack and consumption

Isshiki, R.; Iritani, R.

10.1101/2025.02.22.639661 — ecology — Posted on 2025-05-27

1062 'Crafting Fishy News': Framing and Attitudinal Positioning in English Newspaper Articles on Mahseer from Their Endemic Range

Das, P.; Binoy, V. V.

10.1101/2025.05.22.655491 — ecology — Posted on 2025-05-27

1063 Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis

Basu, S.; Steenbergen, P.; Gabler, F.; Paix, A.; Ronchi, P.; Bourenkov, G.; Schneider, T.; Hellgoth, J.; Kreshuk, A.; Ozbek, S.; Ikmi, A.

10.1101/2025.05.26.656114 — developmental biology — Posted on 2025-05-27

1064 CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on attachments

Vukusic, K.; Tolic, I. M.

10.1101/2023.10.19.563150 — cell biology — Posted on 2025-05-27

1065 Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes

Sugita, Y.; Hirai, Y.; Goto, S. H.; Tomonaga, K.; Noda, T.; Horie, M.

10.1101/2025.05.26.654368 — microbiology — Posted on 2025-05-27

1066 Object-Centered Spatial Learning in Dynamic Contexts: History-Driven Distractor Suppression and Target Enhancement

Ilksoy, Y. A.; van Moorselaar, D.; Los, S. A.; Theeuwes, J.

10.1101/2024.09.04.611200 — neuroscience — Posted on 2025-05-27

1067 Numerical validation of 3D-VAR data assimilation for estimating network dynamics in multivariate EEGs

Yokoyama, H.; Kitajo, K.

10.1101/2025.05.22.655248 — neuroscience — Posted on 2025-05-27

1068 Unveiling functional-metabolic synergy in the healthy brain: multivariate integration of dynamic FDG-PET and resting-state fMRI

Tarricone, C.; Vallini, G.; Baron, G.; Silvestri, E.; Volpi, T.; Vlassenko, A. G.; Goyal, M. S.; Bertoldo, A.

10.1101/2025.05.21.655345 — neuroscience — Posted on 2025-05-27

1069 Effects of speaker and listener sex on auditory attention decoding performance

Van de Ryck, I.; Heintz, N.; Rotaru, I.; Fieberg, D.; Bertrand, A.; Francart, T.

10.1101/2025.05.22.655324 — neuroscience — Posted on 2025-05-27

1070 Interictal activity fluctuations follow rather than precede seizures on multiple time scales in a mouse model of focal cortical dysplasia

Kudlacek, J.; Chvojka, J.; Kralikova, M.; Kylarova, S.; Ravi, T.; Novak, O.; Otahal, J.; Balastik, M.; Jiruska, P.

10.1101/2025.05.22.655485 — neuroscience — Posted on 2025-05-27

1071 Neural response attenuation for shorter inter-onset intervals between sounds in a natural soundscape

Haupt, T.; Rosenkranz, M.; Bleichner, M. G.

10.1101/2025.05.22.655447 — neuroscience — Posted on 2025-05-27

1072 Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions

Greter, G.; Hummel, S.; Kuenzli, D.; Duenki, N.; Ruoho, N.; Burkhardt, P.; Ganguillet, S.; Radiom, M.; Moresi, C.; Laganenka, L.; Hardt, W.-D.; Geisel, S.; Jordi, S.; Misselwitz, B.; Yilmaz, B.; Slomka, J.; Secchi, E.; Stocker, R.; Slack, E.; Arnoldini, M.

10.1101/2025.05.22.655445 — systems biology — Posted on 2025-05-27

1073 The maternal inflammatory proteome during pregnancy and its role in predicting the risk of spontaneous preterm birth

Laleye, F.; Jackson, R.; Mi, J. D.; Shennan, A. H.; Hezelgrave - Elliott, N.; Vigilante, A.; Camunas-Soler, J.; Rasmussen, M.; Tribe, R. M.

10.1101/2025.05.19.654577 — systems biology — Posted on 2025-05-27

1074 Dark-induced decrease in ascorbate levels in Arabidopsis leaves occurs independently of ascorbate peroxidase and oxidase, recycling enzymes, and senescence signaling

Hamada, T.; Yamamoto, K.; Hamada, A.; Maruta, T.

10.1101/2025.03.30.646231 — plant biology — Posted on 2025-05-27

1075 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia

10.1101/2024.08.10.607441 — pathology — Posted on 2025-05-27

1076 PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer

Young, A. A.; Juhler, I. G.; Pierce, J. R.; Bohlin, H. E.; Onishile, D. S.; Chua, R. N.; Liu, M. E.; Gardner, E. N.; Cottrell, K. A.

10.1101/2025.05.27.656288 — cancer biology — Posted on 2025-05-27

1077 OpenCafeMol: A coarse-grained biomolecular simulator on GPU with its application to vesicle fusion

Murata, Y.; Niina, T.; Takada, S.

10.1101/2025.02.20.639390 — biophysics — Posted on 2025-05-27

1078 DrugForm-DTA: Towards real-world drug-target binding Affinity Model

Khokhlov, I.; Tashchilova, A.; Bugaev-Makarovskiy, N.; Glushkova, O.; Yudin, V.; Keskinov, A.; Yudin, S.; Svetlichnyy, D.; Skvortsova, V.

10.1101/2025.05.22.655461 — bioinformatics — Posted on 2025-05-27

1079 Unified nonparametric analysis of single-molecule spatial omics data using probabilistic indices

Hawinkel, S.; Yang, X.; Poelmans, W.; Motte, H.; Beeckman, T.; Maere, S. G.

10.1101/2025.05.20.654270 — bioinformatics — Posted on 2025-05-27

1080 Blue light sensor-guided opto-modulation for enhanced production of valuable metabolites in microalgae

Singh, R.; Arfin, H. U.; Sharma, A.; KATERIYA, S.

10.1101/2025.05.22.655495 — biochemistry — Posted on 2025-05-27

1081 Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation

Gurung, R.; Lee, C. J. M.; Liehn, E. A.; Nurjanah, S.; Ren, M.; van Kan, J. A.; Villanueva, E.; Amrute, J. M.; Loong, S.; Ackers-Johnson, M.; Ruberto, F. P.; Ng, S. L.; Loo, Y. X.; Chu, J.; Lin, X. Y.; Karampinos, K. I.; Kofidis, T.; Lavine, K. J.; Singaraja, R. R.; Sorokin, V.; Foo, R. S.-Y.

10.1101/2025.05.22.655434 — genomics — Posted on 2025-05-27

1082 Genetic and environmental influences on the distributions of three chromosomal drive haplotypes in maize

Brady, M. J.; Dawe, R. K.

10.1101/2025.05.22.655462 — genetics — Posted on 2025-05-27

1083 Transcriptomic basis of within- and trans-generational predator-induced plasticity in the freshwater snail Physa acuta

Dejeux, L.; Saclier, N.; Tariel-Adam, J.; Hoareau, M.; Lefebure, T.; Konecny, L.; Plenet, S.; Luquet, E.

10.1101/2024.10.16.618730 — evolutionary biology — Posted on 2025-05-27

1084 Pleiotropy and facilitation of local adaptation in the silverleaf sunflower Helianthus argophyllus

Okinedo, U. E.; Moyers, B. T.

10.1101/2025.05.22.655459 — evolutionary biology — Posted on 2025-05-27

1085 Drosophila Metaxin-2 controls beta-barrel biogenesis and muscle growth in a stage-dependent fashion

Xie, X.; Shou, X.; Fan, X.; Li, L.; Ruan, Y.; Li, W.; Shang, W.; Mao, J.

10.1101/2025.05.22.655489 — developmental biology — Posted on 2025-05-27

1086 Investigating oncoprotein-mediated chromatin dysregulation in Drosophila melanogaster uncovers novel modifiers of the developmental impact of H3 K27M and EZHIP

Krabbenhoft, S. D.; Masuda, T. E.; Kaur, Y.; Do, T. J.; Jain, S. U.; Lewis, P. W.; Harrison, M. M.

10.1101/2025.05.26.656136 — developmental biology — Posted on 2025-05-27

1087 Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression

Vukusic, K.; Tolic, I. M.

10.1101/2024.09.29.614573 — cell biology — Posted on 2025-05-27

1088 RHD6LA regulates root hair responses to both symbionts and commensals

Tedeschi, F.; Andersen, S. U.; Quilbe, J.; Fechete, L. I.; Christiansen, S. J.

10.1101/2025.05.22.655471 — molecular biology — Posted on 2025-05-27

1089 Expansion, functional diversification and gene fusion events in the Ato protein family

Ghasemi, F.; Antunes, C. B.; Pyrris, Y.; Ataide, P.; Alves, J.; Fernandes, V.; Alves, R.; Goncalves, A. G.; Casal, M.; Van Genechten, W.; Nysten, J.; Brown, A. J. P.; Van Dijck, P.; Diallinas, G.; Pittis, A. A.; Soares-Silva, I.; Paiva, S.

10.1101/2025.05.26.656167 — microbiology — Posted on 2025-05-27

1090 Structural basis for higher-order DNA binding by a bacterial transcriptional regulator

Henriksen, F. O. G.; Van, L. B.; Brodersen, D. E.; Bager Skjerning, R.

10.1101/2024.05.20.595033 — microbiology — Posted on 2025-05-27

1091 Mild traumatic brain injury alters function in the dorsolateral prefrontal cortex: a TMS-EEG study.

Moore, E.; Webb, E.; Sasaki, R.; Rogasch, N. C.; Foo, N.; Semmler, J. G.; Opie, G. M.

10.1101/2025.05.22.655676 — neuroscience — Posted on 2025-05-27

1092 Patterns of Structural Disconnection Driving Proprioceptive Deficits After Stroke

Kaeja, M.; Gajiyeva, L.; Iturria-Medina, Y.; Villringer, A.; Sehm, B.; Steele, C. J.

10.1101/2025.05.22.655663 — neuroscience — Posted on 2025-05-27

1093 GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model

Baspinar, E.; Simonti, M.; Srour, H.; Desroches, M.; Avitabile, D.; Mantegazza, M.

10.1101/2024.10.24.620012 — neuroscience — Posted on 2025-05-27

1094 Rhythmic sampling of multiple decision alternatives in the human brain

Siems, M.; Cao, Y.; Tohidi-Moghaddam, M.; Donner, T. H.; Tsetsos, K.

10.1101/2023.12.08.570734 — neuroscience — Posted on 2025-05-27

1095 Systems modeling reveals that store-operated calcium entry modulates force and fatigue during exercise

Francis, E. A.; Hamid, J.; Kumar, A.; Rangamani, P.

10.1101/2025.05.22.655415 — systems biology — Posted on 2025-05-27

1096 Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan

Hilsabeck, T. A.; Rea, S. L.

10.1101/2024.11.22.623650 — systems biology — Posted on 2025-05-27

1097 Bayesian Independent Component Analysis reconstructs independent modules of gene expression

Carrasco Muriel, J.; Groves, T.; Nielsen, L. K.

10.1101/2025.05.22.655463 — systems biology — Posted on 2025-05-27

1098 Towards pharmacokinetic profile predictions for monoclonal antibodies using sequence based machine learning derived parameters and compartmental modeling

Jost, F.; Cordes, H.

10.1101/2025.05.22.655474 — systems biology — Posted on 2025-05-27

1099 Primitive Molecular Buffering by Low-Multivalency Coacervates

Choi, S.; Liu, S.; Meyer, M. O.; Bevilacqua, P. C.; Keating, C. D.

10.1101/2025.05.22.655649 — biophysics — Posted on 2025-05-27

1100 AdDeam: A Fast and Scalable Tool for Estimating and Clustering Reference-Level Damage Profiles

Kraft, L.; Korneliussen, T. S.; Sackett, P. W.; Renaud, G.

10.1101/2025.03.20.644297 — bioinformatics — Posted on 2025-05-27

1101 Human readable compression of GFA paths using grammar-based code

Heringer, P.; Doerr, D.

10.1101/2025.05.22.655470 — bioinformatics — Posted on 2025-05-27

1102 Effects of 3-Nitrooxypropanol on Methane Emission, Growth and Feed Intake in Growing Calves from 5 Months of Age

Burgers, E. E. A.; Bannink, A.; Walker, N.; Zihlmann, R.; van Gastelen, S.

10.1101/2025.05.22.655456 — biochemistry — Posted on 2025-05-27

1103 In-situ diversification and regional attributes shape asymmetric diversity of Miliusa (Annonaceae) in tropical Asia.

Gopal, A.; Page, N.; Kumar, A.; Tiwari, N.; Sundaresan, V.; Joshi, J.

10.1101/2025.05.22.655121 — evolutionary biology — Posted on 2025-05-27

1104 AID-mediated protein knockdown reveals the requirement of NANOS2 in prenatal gonocytes for establishing functional spermatogonial stem cells

Saga, Y.; Wu, Q.

10.1101/2025.05.22.655677 — developmental biology — Posted on 2025-05-27

1105 ATAD2 mediates chromatin-bound histone chaperone turnover

Liakopoulou, A.; Boussouar, F.; Perazza, D.; Barral, S.; Lambert, E.; Wang, T.; Chuffart, F.; Bourova-Flin, E.; Gard, C.; Puthier, D.; Rousseaux, S.; Arnoult, C.; Verdel, A.; Khochbin, S.

10.1101/2024.10.04.616609 — developmental biology — Posted on 2025-05-27

1106 Viral commitment to infection depends on host metabolism

Marantos, A.; Sneppen, K.; Brown, S.; Mitarai, N.

10.1101/2025.04.30.651438 — microbiology — Posted on 2025-05-27

1107 Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial

Lin, X.; Cottrell, C. A.; Kalyuzhniy, O.; Tingle, R.; Kubitz, M.; Lu, D.; Yuan, M.; Schief, W. R.; Wilson, I. A.

10.1101/2025.05.22.655646 — immunology — Posted on 2025-05-27

1108 Edible Bird's Nest Enhances Memory and Learning in a Rat Model of Sporadic Alzheimer's Disease

Ibrahim, N. H.; Yahaya, M. F.; Teoh, S. L.; Mohamed, W.; Hui, C. K.; Ugusman, A.; Kumar, J.

10.1101/2025.05.22.655527 — neuroscience — Posted on 2025-05-27

1109 Heterogeneity of functional cellular properties for neurons in mouse cerebral cortex

Ballbe, J.; Calice, M.; Gajowa, M.; Graham, L.

10.1101/2025.03.25.645203 — neuroscience — Posted on 2025-05-27

1110 Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.

Ricos, M. G.; Cole, B. A.; Hussain, R.; Rychkov, G. G.; Shaukat, Z.; Pilati, N.; Muench, S. P.; Simmons, K. J.; Dibbens, L. M.; Lippiat, J. D.

10.1101/2025.05.22.655336 — pharmacology and toxicology — Posted on 2025-05-27

1111 Cellular Senescence Affects ECM Regulation in COPD Lung Tissue

Woldhuis, R. R.; Bekker, N. J.; Nijnatten, J. L. L.; Banchero, M.; Kooistra, W.; Wolters, K. J. C.; Horvatovich, P. L.; Guryev, V.; van den Berge, M.; Timens, W.; Brandsma, C.-A.

10.1101/2023.08.02.551614 — pathology — Posted on 2025-05-27

1112 A Global Thermodynamic-Kinetic Model Capturing the Hallmarks of Liquid-Liquid Phase Separation and Amyloid Aggregation

Bhandari, K.; Sun, Y.; Tang, H.; Ke, P. C.; Ding, F.

10.1101/2025.05.23.655849 — biophysics — Posted on 2025-05-27

1113 Cryogenic light microscopy of vitrified samples with Angstrom precision

Mazal, H.; Wieser, F.-F.; Bollschweiler, D.; Sandoghdar, V.

10.1101/2025.05.27.656160 — biophysics — Posted on 2025-05-27

1114 Bridging Scales: Spectral Theory Reveals How Local Connectivity Rules Sculpt Global Neural Dynamics in Spatially Extended Networks

Huang, Y.; Gao, K.; Yang, D.; Song, S.; Chen, G.

10.1101/2025.05.23.655871 — biophysics — Posted on 2025-05-27

1115 Direct observation of single intrinsically disordered proteins in solution

Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.

10.1101/2025.05.26.656162 — biophysics — Posted on 2025-05-27

1116 Defective splicing of Y-chromosome-linked gigantic genes underlies hybrid male sterility in Drosophila

Fontan, A.; Lannes, R.; Fingerhut, J.; Flynn, J.; Yamashita, Y. M.

10.1101/2025.05.22.655455 — evolutionary biology — Posted on 2025-05-27

1117 The RNA splicing factor PRPF8 is required for left-right organiser cilia function and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

Jiang, F.; Boylan, M.; Maxwell, D. W.; Qureshi, W. M. S.; Rowlands, C. F.; Tenin, G.; Mitchell, K.; Stephen, L. A.; Vasconcelos, E. J.; Wang, D.; Chen, T.; Zha, J.; Liu, J.; Althali, N.; Leordean, D. V.; Gallagher, M. T.; Basu, B.; Szymanska, K.; Veeraghanta, A.; Keavney, B.; Humphries, M. J.; Ellingford, J. M.; Smith, D.; Johnson, C. A.; O'Keefe, R. A.; Roy, S.; Hentges, K. E.

10.1101/2025.05.22.654869 — developmental biology — Posted on 2025-05-27

1118 Insulin-like peptide secretion is mediated by peroxisome-Golgi interplay

König, M. A.; Kucharowski, N.; Ramos, D. P. D.; Soyka, H.; Wunderling, K.; Bülow, T. R.; Yaghmour, M. H.; Thiele, C.; Ache, J. M.; Kuerschner, L.; Bülow, M. H.

10.1101/2025.05.26.656179 — cell biology — Posted on 2025-05-27

1119 Brieflow: An Integrated Computational Pipeline for High-Throughput Analysis of Optical Pooled Screening Data

Di Bernardo, M.; Kern, R.; Mallar, A.; Nutter-Upham, A.; Blainey, P.; Cheeseman, I. M.

10.1101/2025.05.26.656231 — cell biology — Posted on 2025-05-27

1120 PMScanR: an R package for the large-scale identification, analysis, and visualization of protein motifs

Jastrzebski, J. P.; Gawronska, M.; Babis, W.; Quaranta, M.; Czopek, D.

10.1101/2025.05.23.655703 — bioinformatics — Posted on 2025-05-27

1121 Accurate detection of pathogenic structural variants guided by multi-platform comparison

Alavi, N.; Moeinzadeh, M.-H.; Hertzberg, J.; Souto Melo, U.; Ward Al Raei, L.; Infantino, P.; Ghareghani, M.; Savarese, M.; Mundlos, S.; Vingron, M.

10.1101/2025.05.21.655285 — bioinformatics — Posted on 2025-05-27

1122 Graphical and Interactive Spatial Proteomics Image Analysis Workflow

Singh, P.; Wright, J. H.; Smythe, K. S.; Fukuda, B. N.; Hung, L.-H.; Yeung, C. C.; Yeung, K. Y.

10.1101/2025.05.23.655879 — bioinformatics — Posted on 2025-05-27

1123 Levels of telomerase in cancer are contingent on senescence and inflammation at bulk tissue and single-cell spatial resolution

Noureen, N.; Kang, M. H.

10.1101/2025.05.21.655338 — bioinformatics — Posted on 2025-05-27

1124 Brachial Plexus Birth Injury Causes Location-Dependent Detriments in Glenohumeral Trabecular Bone Microstructure

Fawcett, E. B.; Dixit, N. N.; Saul, K. R.; Cole, J. H.

10.1101/2025.05.22.655580 — bioengineering — Posted on 2025-05-27

1125 Novel Highly Pathogenic Avian Influenza (A)H5N1 Triple Reassortant in Argentina, 2025

Vanstreels, R. E. V.; Nelson, M. I.; Artuso, M. C.; Piccini, L. E.; Marchione, V. D.; Benedetti, E.; Crespo-Bellido, A.; Pierdomenico, A.; Wolff, T.; Uhart, M.; Rimondi, A.

10.1101/2025.05.23.655175 — genomics — Posted on 2025-05-27

1126 Iterated language learning is shaped by a drive for optimizing lossy compression

Imel, N.; Culbertson, J.; Kirby, S.; Zaslavsky, N.

10.1101/2025.05.23.655237 — evolutionary biology — Posted on 2025-05-27

1127 Parasitoids reduce growth rate in oak-feeding caterpillars

Molleman, F.; Tambay, A.; Mallick, S.; Llopis, S.; Prinzing, A.; Walczak, U.

10.1101/2025.05.23.655719 — ecology — Posted on 2025-05-27

1128 Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy

Hasson, J. M.; Katusiime, M. G.; Capoferri, A. A.; Bale, M. J.; Luke, B. T.; Shao, W.; Cotton, M. F.; Van Zyl, G.; Patro, S. C.; Kearney, M. F.

10.1101/2025.05.23.655786 — microbiology — Posted on 2025-05-27

1129 Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence within pulmonary fungal granulomas.

Zheng, Y.; Jean Pierre, M.; Ansaldo, E.; Dobson, H. E.; Kamenyeva, O.; Onyishi, C. U.; Dang, E. V.

10.1101/2025.05.23.655817 — immunology — Posted on 2025-05-27

1130 Transcriptomic divergence of network hubs in the prenatal human brain

Oldham, S.; Ball, G.

10.1101/2025.05.26.656237 — neuroscience — Posted on 2025-05-27

1131 The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer

Soegyono, O.; Pepin, E.; Leung, B. K.; Chieng, B.; Balleine, B. W.; Laurent, V.

10.1101/2025.05.26.656228 — neuroscience — Posted on 2025-05-27

1132 A trace-based analysis pipeline for coherent and optimized electrophysiological data analysis

Ballbe, J.; Calice, M.; Gajowa, M.; Graham, L. J.

10.1101/2025.03.25.645208 — neuroscience — Posted on 2025-05-27

1133 Similar does not mean same: ERP correlates of processing mental and physical experiencer verbs in Malayalam complex constructions

Shalu, S.; Muralikrishnan, R.; Choudhary, K. K.

10.1101/2025.05.21.655344 — neuroscience — Posted on 2025-05-27

1134 Dual roles of Drosophila reward-encoding dopamine neurons in regulating innate and learned behaviors

Lozada-Perdomo, F. V.; Chen, Y.; Jacobs, R. V.; Yeo, J.; Yang, M.; Bhalerao, J.; Devineni, A. V.

10.1101/2025.05.26.656192 — neuroscience — Posted on 2025-05-27

1135 Prevalence of sympathetic fibers within the rat cervical vagus, and functional consequence on physiological effects mediated by vagus nerve stimulation (VNS).

Deshmukh, A.; Chen, R. C.-H.; Chin, J.; Knudsen, B.; Trevathan, J.; Shoffstall, A.; Ludwig, K.

10.1101/2025.05.21.655349 — neuroscience — Posted on 2025-05-27

1136 Cell Density and mRNA Expression of Inhibitory Interneurons in Schizophrenia: A Meta-Analysis

Mulvey, A. G.; Gabhart, K. M.; Grent-T-Jong, T.; Herculano-Houzel, S.; Uhlhaas, P. J.; Bastos, A. M.

10.1101/2025.05.23.655812 — neuroscience — Posted on 2025-05-27

1137 Neuroticism Heterogeneity Through Item-Level Associations in Resting-State Functional Connectivity

Misaki, M.; Fan, C. C.; Thompson, W. K.; Park, H.; Xu, B.; Paulus, M. M.

10.1101/2025.05.23.655856 — neuroscience — Posted on 2025-05-27

1138 Rising together: Exploring Sourdough Fermentation Diversity through Co-design in the HealthFerm Citizen Science Initiative

Meyer, A. R.; Gettemans, T.; Tan, J. P.; Tucillo, F.; Viretto, C.; Angelescu, I.-R.; De Bondt, Y.; Neugebauer, M.; Zein Alabiden Tlais, A.; Cavelti, F.; De Vuyst, L.; Gobbetti, M.; Courtin, C. M.; Zamfir, M.; Coda, R.; Nystroem, L.; Weckx, S.; Bokulich, N. A.

10.1101/2025.05.23.655785 — scientific communication and education — Posted on 2025-05-27

1139 Harnessing distinct tissue-resident immune niches via S100A9/TLR4 improves ketone, lipid, and glucose metabolism

Lucibello, G.; Ursino, G.; Teixeira, P. D. S.; Zahoran, S.; Fanuele, F.; Kallikourdis, M.; Visentin, F.; Veyrat-Durebex, C.; Widmer, A.; Wu, Y.; Cremonesi, M.; Wollheim, C. B.; Castets, P.; Ramadori, G.; Coppari, R.

10.1101/2025.05.21.655283 — physiology — Posted on 2025-05-27

1140 Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

Brown, T. P.; Chavent, M.; Im, W.

10.1101/2025.05.24.655956 — biophysics — Posted on 2025-05-27

1141 Performance of blood-based biomarkers for human circadian pacemaker phase: Training sets matter as much as feature selection methods

Moller-Levet, C. S.; Archer, S. N.; Dijk, D.-J.

10.1101/2025.05.21.655317 — bioinformatics — Posted on 2025-05-27

1142 DNA sequence encoded conformational flexibility orchestrates pioneer transcription factor nucleosome interaction landscape

Dey, U.; Martinez, G. S.; Yella, V. R.; Kumar, A.

10.1101/2025.05.21.655105 — bioinformatics — Posted on 2025-05-27

1143 Influence of ionic liquids on enzymatic asymmetric carboligations

Gerhards, T.; El Harrar, T.; Klein, A. S.; von Lieres, E.; Paul, C. E.; Lavandera, I.; Gotor-Fernandez, V.; Pietruszka, J.; Pohl, M.; Gohlke, H.; Rother, D.

10.1101/2025.05.21.655364 — bioengineering — Posted on 2025-05-27

1144 Controlled delivery of immunomodulatory factors for mineralized tissue formation in an inflammatory microenvironment

Griffin, K. H.; Sagheb, I. S.; Coonan, T. P.; Wu, L. A.; Rowland, D. J.; Arzi, B.; Lewis, J.; Leach, K.

10.1101/2025.05.21.655332 — bioengineering — Posted on 2025-05-27

1145 A Novel Human Distal Tubuloid-On-A-Chip Model For Investigating Sodium And Water Transport Mechanisms

Dorileo Leite Bernardi, M. D. L.; Dilmen, E.; Kurek, D.; Lanz, H.; Joore, J.; Hoenderop, J.; Rookmaaker, M. B.; Verhaar, M. C.

10.1101/2025.03.27.644139 — bioengineering — Posted on 2025-05-27

1146 Molecular mechanism of substrate transport by human peroxisomal ABCD3

Gupta, M.; Khandelwal, N. K.; Seka, D. J.; Balasubramani, S. G.; Dickinson, M. S.; Myasnikov, A.; Echeverria, I.; Stroud, R. M.

10.1101/2025.05.21.655323 — biochemistry — Posted on 2025-05-27

1147 A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway

Steiner, W. P.; Iverson, N.; Liu, G.; Venkatakrishnan, V.; Wu, J.; Stepniewski, T. M.; Michaelson, Z.; Broeckel, J.; Zhu, J.-F.; Bruystens, J.; Lee, A.; Nelson, I.; Bertinetti, D.; Arveseth, C. D.; Tan, G.; Spaltenstein, P.; Xu, J.; Huttenhain, R.; Kay, M.; Herberg, F. W.; Selent, J.; Anand, G. S.; Dunbrack, R. L.; Taylor, S. S.; Myers, B. R.

10.1101/2024.10.31.621410 — biochemistry — Posted on 2025-05-27

1148 The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin

Carlson, E. S.; Haslecker, R.; Lecchi, C.; Ramos, M. A.; Vennelakanti, V.; Honaker, L.; Stornetta, A.; Millan, E. S.; Johnson, B. A.; Kulik, H. J.; Balbo, S.; Villalta, P. W.; D'Souza, V.; Balskus, E. P.

10.1101/2025.05.26.655968 — biochemistry — Posted on 2025-05-27

1149 On the Stability of Silicone-Encapsulated CMOS ICs for Active Implantable Devices: 4.3 Years of Accelerated Life Testing

Shah Idil, A.; Lamont, C.; Nanbakhsh, K.; Mazza, F.; Giagka, V.; Constandinou, T.; Vanhoestenberghe, A.; Donaldson, N.

10.1101/2025.05.21.655306 — biochemistry — Posted on 2025-05-27

1150 Octopus "Hypnosis": Inducing Tonic Immobility for Studying Local Sensorimotor Responses and Arm-Sucker Coordination

Gribkova, E. D.; Cui, J.; Gillette, R.

10.1101/2024.04.22.590669 — animal behavior and cognition — Posted on 2025-05-27

1151 Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomics

Shetty, A. C.; Verma, A.; Sivinski, J.; Fan, X.; Doty, C.; Hollander, B.; Roche, D.; Seneviratne, C.

10.1101/2025.05.21.655347 — genomics — Posted on 2025-05-27

1152 The study of differential expressions of MCPH and Seckel syndrome genes and their paralogues

Khurshid, M.; Mohsin, M.; Riaz, S.; Imran, M.; Cox, J. J.

10.1101/2025.05.21.655339 — genetics — Posted on 2025-05-27

1153 Ancient and recent riverine gene flow contributed to the adaptive radiation of sailfin silversides in Wallace's Dreampond

De Keyzer, E. L. R.; Herder, F.; Boehne, A.; Campuzano Jimenez, F.; Burskaia, V.; Kukowka, S.; Tracey, A.; Denton, A. L.; Oatley, G.; Tree of Life programme, ; Scientific Operations: DNA Pipelines collective, ; Core Informatics collective, ; Mokodongan, D. F.; Wowor, D.; Svardal, H.

10.1101/2025.04.16.648611 — evolutionary biology — Posted on 2025-05-27

1154 Off target: herbicides applied in cereal fields exclude non-competitive species, while replacing them by competitive weeds.

Humann-Guilleminot, S.; Bretagnolle, V.; Gaba, S.

10.1101/2025.05.21.654858 — ecology — Posted on 2025-05-27

1155 METTL3 regulates exocytosis independently of m6A

Esteva-Socias, M.; Battharai, D. P.; Achour, C.; Baidya, P.; Fontanari, G.; Seier, K.; Pace, H.; Malla, S.; Zhu, S.; Lundin, E.; Vagbo, C. B.; Bally, M.; Swaminathan, V. S.; Mateus, A.; Rodriguez-Barrueco, R.; Pich, A.; Aguilo, F.

10.1101/2025.05.26.656168 — molecular biology — Posted on 2025-05-27

1156 Mechanosensitive Endothelial METTL7A Regulates Internal m7G mRNA Methylation and Protects Against Atherosclerosis

Shentu, T.-P.; Wu, T.; Zhou, Z.; Yeh, C.-F.; Zhu, J.; Li, J.; Miao, B. A.; Lee, T.-H.; Zhang, L.; Huang, R.-T.; Harrison, D.; Hodonsky, C. J.; Auguste, G.; Husain, A.; Tirrell, M. V.; Miller, C. L.; Dickinson, B.; Yang, K.-C.; Fang, Y.

10.1101/2025.05.22.655328 — molecular biology — Posted on 2025-05-27

1157 Characterization of intermolecular base pairing using AMT crosslinking in mammalian cells during oxidative stress

Liao, J. N.; Betances, I.; Tian, S.; Shen, E.; Ye, Z.; Basu, A.; Trcek, T.

10.1101/2025.05.21.655305 — molecular biology — Posted on 2025-05-27

1158 Applying environmental DNA metabarcoding to calculate an index of biotic integrity for freshwater fish

Curtis, A. N.; Harper, L. R.; Davis, M. A.; Larson, E. R.

10.1101/2025.05.26.656190 — molecular biology — Posted on 2025-05-27

1159 Simple, rapid, and sensitive assay for the quantification of total polysaccharides to estimate extracellular polymeric substances (EPS) in soil

Bogar, G.; Lennon, J. T.; Vander Stel, H. M.; Evans, S. E.

10.1101/2025.05.22.654594 — molecular biology — Posted on 2025-05-27

1160 Comparative Analysis of the Microbiota of Vaccinium myrtillus and Vaccinium uliginosum in the Central Italian Apennines

Vaccaro, F.; Cambi, G.; Biricolti, S.; Giordani, E.; Mengoni, A.; Fagorzi, C.

10.1101/2025.05.26.655108 — microbiology — Posted on 2025-05-27

1161 Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes

Sugita, Y.; Hirai, Y.; Goto, S. H.; Tomonaga, K.; Noda, T.; Horie, M.

10.1101/2025.05.26.654368 — microbiology — Posted on 2025-05-27

1162 Tracking Persistence and Dynamics of Active Soil Viruses with SIP-Viromics

Trubl, G.; Roux, S.; Kellom, M.; Vyshenska, D.; Tomatsu, A.; Singh, K.; Kimbrel, J.; Eloe-Fadrosh, E. A.; Malmstrom, R. R.; Pett-Ridge, J.; Blazewicz, S. J.

10.1101/2025.05.25.655894 — microbiology — Posted on 2025-05-27

1163 Complete genomes of Rickettsia typhi reveal a clonal population

Keeratipusana, C.; Phuklia, W.; Phommadeechack, V.; Thaipadungpanit, J.; Chansamouth, V.; Phommasone, K.; Rattanavong, S.; Moore, C. E.; Robinson, M. T.; Richards, A. L.; Newton, P. N.; Batty, E. M.

10.1101/2025.05.25.654783 — microbiology — Posted on 2025-05-27

1164 NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates

GLON, D.; Riller, Q.; Riviere, F.; Leonardon, B.; Guillemot, A.; Sago, L.; Pelle, O.; Ho-Nhat, D.; Brochard, K.; Bader-Meunier, B.; Fremond, M.-L.; Lepelley, A.; Crow, Y.; Tusseau, M.; Belot, A.; Lagaudriere-Gesbert, C.; Rieux-Laucat, F.; GAUDIN, Y.

10.1101/2025.05.21.655319 — immunology — Posted on 2025-05-27

1165 GABA-induced Ca2+ signaling in the primary cilium of neurons

Sanchez, G.; Sodergren, M.; Maurya, D. K.; Gronbladh, A.; Lindskog, M.; Idevall-Hagren, O.

10.1101/2025.05.26.656109 — neuroscience — Posted on 2025-05-27

1166 Differential contributions of low-frequency phase and power in crossmodal temporal prediction: A MEG study

Burke, R.; Daume, J.; Schneider, T. R.; Engel, A. K.

10.1101/2025.05.26.656128 — neuroscience — Posted on 2025-05-27

1167 Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training

Hawthorn, R.; Phelps, N.; Atkinson, C.; Keesey, R. E.; Seitz, Z.; Nie, H.; Seanez, I.

10.1101/2025.05.21.655351 — neuroscience — Posted on 2025-05-27

1168 Proteomic changes associated with the initiation and termination of aestivation in the cabbage stem flea beetle

Güney, G.; Cedden, D.; Scholten, S.; Rostas, M.

10.1101/2025.05.21.655265 — zoology — Posted on 2025-05-27

1169 Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

Bhuiyan, P.; Yi, Y.; Wei, B.; Yan, A.; Dong, L.; Wei, H.

10.1101/2025.05.21.655232 — pharmacology and toxicology — Posted on 2025-05-27

1170 End Processing in NHEJ by Polymerase {lambda} and PNKP is coordinated during short-range synapsis

Vogt, A.; Kaminski, A. M.; Pedersen, L. C.; Naila, T.; Tomkinson, A. E.; Lees-Miller, S. P.; Kunkel, T. A.; He, Y.

10.1101/2025.05.25.656038 — biophysics — Posted on 2025-05-27

1171 MassiveFold data for CASP16-CAPRI: a systematic massive sampling experiment

Raouraoua, N.; Lensink, M. F.; Brysbaert, G.

10.1101/2025.05.26.653955 — bioinformatics — Posted on 2025-05-27

1172 VIProDesign: Viral Protein Panel Design for Highly Variable Viruses to Evaluate Immune Responses and Identify Broadly Neutralizing Antibodies

Bylund, T.; El Anbari, M.; Schaub, A.; Zhou, T.; Rawi, R.

10.1101/2025.05.21.654924 — bioinformatics — Posted on 2025-05-27

1173 SCOT+: A Comprehensive Software Suite for Single-Cell alignment Using Optimal Transport

Baker, C. D.; Pham, T. M.; Demetci, P.; Tran, Q.-H.; Redko, I.; Sandstede, B.; Singh, R.

10.1101/2025.05.21.655322 — bioinformatics — Posted on 2025-05-27

1174 DynaRNA: Dynamic RNA Conformation Ensemble Generation with Diffusion Model

Chen, H.; Li, Z.; Zhu, J.; Hong, X.; Zheng, Z.; Cui, T.; Sun, Y.; Wei, T.

10.1101/2025.05.22.655453 — bioinformatics — Posted on 2025-05-27

1175 Artemisia Database: A Comprehensive Resource for Gene Expression and Functional Insights in Artemisia annua

Taheri, A.; Almeida-Silva, F.; Zhang, Y.; Fu, X.; Li, L.; Wang, Y.; Tang, K.

10.1101/2025.05.21.655314 — bioinformatics — Posted on 2025-05-27

1176 SCALE: Unsupervised Multi-Scale Domain Identification in Spatial Omics Data

Yousefi, B.; Schaub, D. P.; Khatri, R.; Kaiser, N.; Kuehl, M.; Ly, C.; Puelles, V. G.; Huber, T. B.; Prinz, I.; Krebs, C. F.; Panzer, U.; Bonn, S.

10.1101/2025.05.21.653987 — bioinformatics — Posted on 2025-05-27

1177 Substrate-induced assembly and functional mechanism of the bacterial membrane protein insertase SecYEG-YidC

Busch, M.; Hernandez, C. R.; Kamel, M.; Schaumkessel, Y.; van der Sluis, E.; Berninghausen, O.; Becker, T.; Beckmann, R.; Kedrov, A.

10.1101/2025.05.26.656142 — biochemistry — Posted on 2025-05-27

1178 Mechanism of activation of an ancestral Tec kinase by PIP3

Krötenheerdt, E.; von Raussendorf, F.; Reinhardt, R.; Piëch, L.; Wedige, N.; Nyvall, H. G.; Burke, J. E.; Leonard, T. A.

10.1101/2025.05.22.653117 — biochemistry — Posted on 2025-05-27

1179 Perturbation of epithelial and limbal stem cell identity in a mouse model of pathologic corneal neovascularization

Abbasi, M.; Arts, J. A.; Javidjam, S.; Moustardas, P.; Dashti, A.; Aberdam, D.; Zhou, H.; Lagali, N.

10.1101/2025.05.22.655502 — molecular biology — Posted on 2025-05-27

1180 Whole-genome sequencing of diverse 351 cultured prokaryotes including yet-unsequenced fastidious type strains

Kato, S.; Masuda, S.; Shibata, A.; Itoh, T.; Sakamoto, M.; Shirasu, K.; Ohkuma, M.

10.1101/2025.05.25.655001 — microbiology — Posted on 2025-05-27

1181 Identification and In Silico Characterization of Novel lncRNAs Associated with Dengue Infection

Pandey, A. D.; Kuldeep, J.; Vrati, S.; Banerjee, A.

10.1101/2025.05.08.652916 — bioinformatics — Posted on 2025-05-26

1182 High-throughput mapping of spontaneous mitotic crossover and genome instability events with sci-L3-Strand-seq

Chovanec, P.; Ridgley, T.; Yin, Y.

10.1101/2025.05.19.654945 — genomics — Posted on 2025-05-26

1183 From Transporter to Motor: Evolutionary and Structural Insights into the Emergence of Prestin's Area-Motor Activity in Mammals

Fuentes-Ugarte, N.; Ruiz-Rojas, T.; Ruiz-Fernandez, A.; Garate, J. A.; Castro-Fernandez, V.; Araya-Secchi, R.

10.1101/2025.04.11.648445 — evolutionary biology — Posted on 2025-05-26

1184 The membrane topology problem inherent in ciliogenesis is solved by ciliary recruitment of a phospholipid flippase

Wang, Z.; He, R.; Liu, Q.; Snell, W. J.; Cao, M.; Pan, J.

10.1101/2025.01.13.632862 — cell biology — Posted on 2025-05-26

1185 Task-guided Generative Adversarial Networks for Synthesizing and Augmenting Structural Connectivity Matrices for Connectivity-Based Prediction

Yamamoto, T.; Sugiura, T.; Hiroyasu, T.; Hiwa, S.

10.1101/2024.02.13.580039 — neuroscience — Posted on 2025-05-26

1186 Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions

El Kadri, M.; Guegan, F.; Sharma, P.; Calvo Alvarez, E.; Pineda, E.; Morand, P.; Ngoune, J. M.; Escard, J.; Dupuy, J.-W.; Rimoldi, A.; Plazolles, N.; Biran, M.; Barrett, M. P.; Figueiredo, L. M.; Rotureau, B.; Bringaud, F.

10.1101/2025.05.26.656071 — microbiology — Posted on 2025-05-26

1187 Metabolic and transcriptomic insights into a GalNAc/Man-Specific lectin in yeast fermentation

Liu, S.; Li, L.; Niu, H.; Li, W.; Tong, C.

10.1101/2025.05.26.656115 — microbiology — Posted on 2025-05-26

1188 Avian Influenza in Ireland: A Spatiotemporal, Subtype, and Host-Based Analysis (1983-2024)

Farrell, M. L.; McGrath, G.; Cuartero, L. G.; Barry, G.

10.1101/2025.05.26.656175 — microbiology — Posted on 2025-05-26

1189 Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol.

GSCHWIND, R.; Bonnet, M.; Abramova, A.; Jarquin Diaz, V. H.; Wenne, M.; Loeber, U.; Godron, N.; Kampouris, I. D.; Tskhay, F.; Naheed, F.; Debroucker, C.; Bui-Hai, M.; El Aiba, I.; Klumper, U.; Berendonk, T. U.; Forslund-Startceva, S. K.; Zahra, R.; Bengtsson-Palme, J.; RUPPE, E.

10.1101/2025.05.26.656069 — microbiology — Posted on 2025-05-26

1190 Widespread and Abundant CRISPR-Cas Systems in the Deep Ocean

Sanchez, P.; Ferri-Peradalta, M.; Garcia, E. M. L.; Ruiz, R.; Ruvira, B. E.; Gasol, J. M.; Vaque, D.; Gojobori, T.; Agusti, S. R.; Duarte, C. M.; Mojica, F. J.; Ceron, J.; Coutinho, F. H.; Acinas, S. G.

10.1101/2025.05.26.656144 — microbiology — Posted on 2025-05-26

1191 Widespread potential for phototrophy and convergent reduction of lifecycle complexity in the dimorphic order Caulobacterales

Hallgren, J.; Dharamshi, J. E.; Rodriguez-Gijon, A.; Nuy, J.; Garcia, S. L.; Jonas, K.

10.1101/2025.05.26.656076 — microbiology — Posted on 2025-05-26

1192 Expansion, functional diversification and gene fusion events in the Ato protein family

10.1101/2025.05.26.656167 — microbiology — Posted on 2025-05-26

1193 Genotypic Characterization of Virulence and Antibiotic-Heavy Metal Resistance in Enterococcus Strains from Vladivostoks Water Bodies

Kim, J. H.; Hujuri, M.; Uskova, S. S.; Martynova, A. V.

10.1101/2025.05.26.656074 — microbiology — Posted on 2025-05-26

1194 A Salmonella type I toxin promotes systemic infection by inhibiting FoF1 ATP synthase

Kim, S.; Kim, S.; Lee, E.-J.

10.1101/2025.05.26.656083 — microbiology — Posted on 2025-05-26

1195 Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

Weight, C. M.; Pollara, G. M.; Betts, M.; Ragazzini, R.; Connor, M.; Ramos-Sevillano, E.; Reine, J.; Whelan, M.; Guerra-Assuncao, J. A.; Bonfanti, P.; Jolly, C.; Noursadeghi, M.; Ferreira, D.; Brown, J.; Heyderman, R. S.

10.1101/2023.06.15.545009 — microbiology — Posted on 2025-05-26

1196 Fast and robust visual object recognition in young children

Ayzenberg, V.; Sener, S. B.; Novick, K.; Lourenco, S. F.

10.1101/2024.10.14.618285 — neuroscience — Posted on 2025-05-26

1197 Multidirectional alignment of collagen fibers to guide cell orientation in 3D-printed tissue

Singhal, D.; Christakopoulos, F.; Brunel, L. G.; Borkar, S.; Doulames, V. M.; Myung, D.; Fuller, G. G.; Heilshorn, S. C.

10.1101/2025.05.20.654730 — bioengineering — Posted on 2025-05-26

1198 Somatic evolution of stem cell mutations in long-lived plants

Johannes, F.

10.1101/2025.01.13.632685 — evolutionary biology — Posted on 2025-05-26

1199 Benchmarking and Optimization of Methods for the Detection of Identity-By-Descent in High-Recombining Plasmodium falciparum

Guo, B.; Takala-Harrison, S.; O'Connor, T. D.

10.1101/2024.05.04.592538 — evolutionary biology — Posted on 2025-05-26

1200 The evolution of Hutchinsonian climatic niche hypervolumes in gymnosperms

Caron, F.; Burslem, D. F.; Morimoto, J.

10.1101/2025.01.26.634928 — ecology — Posted on 2025-05-26

1201 Gene set optimization for cancer transcriptomics using sparse principal component analysis

Frost, H. R.

10.1101/2025.05.21.655279 — bioinformatics — Posted on 2025-05-26

1202 EXPRESSION GRAPH NETWORK FRAMEWORK FOR BIOMARKER DISCOVERY

Liu, Y.; Huse, J. T.; Kannan, K.

10.1101/2025.04.28.651033 — bioinformatics — Posted on 2025-05-26

1203 Diet-derived vitamin B12 induces transgenerational inheritance of nematode predation through elevated vitellogenin provisioning

Quiobe, S. P.; Kalirad, A.; Zurheide, R.; Witte, H.; Roedelsperger, C.; Sommer, R. J.

10.1101/2025.05.21.655301 — genetics — Posted on 2025-05-26

1204 Persistent nitrogenase isotope signatures over two billion years of engineered evolution

Rucker, H.; Bubphamanee, K.; Harris, D.; Konhauser, K.; Seefeldt, L.; Buick, R.; Kacar, B.

10.1101/2025.05.21.655380 — evolutionary biology — Posted on 2025-05-26

1205 A novel molecular sexing method for Greater One-horned Rhinoceros (Rhinoceros unicornis) for reliable demographic assessments

Kumar, S.; Ghosh, T.; Sharma, A.; Mondol, S.

10.1101/2025.05.21.655307 — ecology — Posted on 2025-05-26

1206 Stochastic splicing and deterministic inclusion of exon variables promote diversification of Down Syndrome Cell Adhesion Molecule expression

Lassota, A.; Dix, T. C.; Soller, M.

10.1101/2025.05.21.655277 — molecular biology — Posted on 2025-05-26

1207 Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

Coley, A. K.; Nawrocki, C.; Patel, B. K.; Pankaj, A.; Guo, Z.; Emmett, M. J.; Lang, E. R.; Song, Y.; Xu, K. H.; Ferrone, C. R.; Deshpande, V.; Nieman, L. T.; Aryee, M.; Franses, J. W.; Ting, D. T.

10.1101/2023.12.04.570014 — cancer biology — Posted on 2025-05-26

1208 Cell Morphology and Biophysical Mechanisms-Informed Traction Force Microscopy Using Machine Learning

Fujiwara, K.; Fujikawa, R.; Suzuki, Y.; Suzuki, K. T.; Sakumura, Y.

10.1101/2025.05.21.655282 — biophysics — Posted on 2025-05-26

1209 A protein-DNA surface hydrogel mechanically protects the cell nucleus

Adakkattil, R.; Mandal, P.; Savich, Y.; Ruffine, V.; Jordan, M. A.; Pinholt, H. D.; Fischer-Friedrich, E.; Julicher, F.; Grill, S. W.; Von Appen, A.

10.1101/2025.05.21.655270 — biophysics — Posted on 2025-05-26

1210 CSFeatures improves identification of cell type-specific differential features in single-cell and spatial omics data

Li, R.; Li, Y.; Hua, H.; Li, Z.; Zhang, Y.; Yao, Y.; Chen, S.; Xu, Y.

10.1101/2025.05.21.655244 — bioinformatics — Posted on 2025-05-26

1211 TypeSINE: Genome-Wide Detection of SINE Retrotransposon Polymorphisms Reveals Functional Variants Linked to Body Size Variation in Pigs

Zheng, Y.; Yang, N.; Chen, C.; Zong, W.; Chen, H.; Shi, S.; Wang, X.; Murani, E.; Reyer, H.; Gao, B.; Zhang, L.; Wimmers, K.; Song, C.

10.1101/2025.05.21.653756 — bioinformatics — Posted on 2025-05-26

1212 Empirical validation of ephaptic coupling in printed human neural circuits

Striebel, J.; Habibey, R.; Wendland, D.; Gehring, H.; Podoliak, E.; Pawlick, J. S.; Sharma, K.; Ng, A. H. M.; Pernice, W.; Busskamp, V.

10.1101/2025.05.21.655141 — bioengineering — Posted on 2025-05-26

1213 A Plug-and-Play P300-Based BCI with Calibration-Free Application

Kim, J.; Kim, S.-P.

10.1101/2025.05.21.655021 — bioengineering — Posted on 2025-05-26

1214 aDISCO: A Broadly Applicable Method for 3D Microscopy of Archival Paraffin-Embedded Human Tissues

Reuss, A. M.; Rupprecht, P.; Groos, D.; Cerisoli, M.; Nordberg, L.; Frick, L.; Voigt, F.; Vladimirov, N.; Bethge, P.; Reimann, R.; Helmchen, F.; Aguzzi, A.

10.1101/2025.05.21.655358 — bioengineering — Posted on 2025-05-26

1215 Frustratingly easy domain adaptation for cross-speciestranscription factor binding prediction

Ebeid, M. M.; Balci, A. T.; Chikina, M.; Benos, P. V.; Kostka, D.

10.1101/2025.05.21.655414 — genomics — Posted on 2025-05-26

1216 Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing

Trotman, J. B.; Porrello, A.; Schactler, S. A.; DeLeon, L. E.; Eberhard, Q. E.; Boyson, S. P.; Zhang, Z.; Lee, D. M.; Kirik, S. E.; Nguyen, S. N.; Beltejar, M.-C. G.; Shinn, M. K.; Ong, S.-E.; Gonzalez-Perez, M. P.; Shaffer, S. A.; Dominguez, D.; Shechner, D. M.; Calabrese, M.

10.1101/2025.05.21.655143 — genetics — Posted on 2025-05-26

1217 Male accessory gland size depends on genotypes but not larval density conditions in nutrition-rich environments

Patlar, B.; Japke, L.; Moehring, S.; Fricke, C.

10.1101/2025.05.21.655081 — evolutionary biology — Posted on 2025-05-26

1218 Neuronal feedback loop in the suprachiasmatic nucleus generates robust circadian rhythms

Wang, M.; Tsuno, Y.; Peng, Y.; Matsui, A.; Maejima, T.; Mieda, M.

10.1101/2025.05.21.655394 — neuroscience — Posted on 2025-05-26

1219 The Arp2/3 complex is required for in situ haptotactic response of microglia to iC3b

Paulson, S. G.; Swafford, I.; Lischka, F. W.; Rotty, J. D.

10.1101/2025.05.21.655384 — neuroscience — Posted on 2025-05-26

1220 Impact of a standardized Tetradesmus obliquus Mi175.B1.a extract on gut function and physiology in inflammatory conditions: in vitro and in vivo insights

MAURY, J.; Albina, P.; Pradelles, R.

10.1101/2025.05.21.655247 — physiology — Posted on 2025-05-26

1221 OptiK: An Entropy-Driven Framework for Optimal k-mer Size Selection for Bacterial Genomics

Gutierrez, A.

10.1101/2025.05.21.655412 — bioinformatics — Posted on 2025-05-26

1222 Toggle-Untoggle: A cell segmentation tool with an interactive user verification interface.

Grishchenko, N.; Byrsan, M.; Olson, M. F.

10.1101/2025.05.21.655178 — bioinformatics — Posted on 2025-05-26

1223 The Mechanism of Histone Ubiquitylation by the ASB9-CUL5 Ubiquitin Ligase

Komives, E. A.; Lee, N. H.; Alipranti, F. X.; Li, H.; Lin, C. P.

10.1101/2025.05.21.655409 — biochemistry — Posted on 2025-05-26

1224 Metabolic Cage Analysis of Surgically Catheterized C57Bl/6J Mice (Mus musculus) Treated with Carprofen and Sustained-release Buprenorphine

Tu, J.; Saenz, M.; Bloom-Saldana, E.; Fueger, P. T.

10.1101/2025.05.21.655398 — animal behavior and cognition — Posted on 2025-05-26

1225 Malaria parasite population genomics during an elimination program in Eastern Myanmar

Li, X.; Arya, G.; Thu, A. M.; Landier, J.; Parker, D.; Delmas, G.; Reyes, A.; Lwin, K. M.; Sriprawat, K.; Nosten, F.; Anderson, T. J.

10.1101/2025.05.21.655408 — genomics — Posted on 2025-05-26

1226 StringTie3 Improves Total RNA-seq Assembly by Resolving Nascent and Mature Transcripts

Shinder, I.; Pertea, G.; Hu, R.; Rudnick, Z.; Pertea, M.

10.1101/2025.05.21.655404 — genomics — Posted on 2025-05-26

1227 High-throughput iNaturalist image analysis reveals flower color divergence in Monarda fistulosa

McKenzie, P. F.; Church, S. H.; Hopkins, R.

10.1101/2025.05.21.655392 — evolutionary biology — Posted on 2025-05-26

1228 Amazon biodiversity is at risk from metal contamination due to mining activity

Moulatlet, G. M.; Capparelli, M.; Thomas, C.; Boyle, B.; Feng, X.; Frazier, A.; Hinojo-Hinojo, C.; Herrera, J.; Nahomi, L.; Lechner, A.; Maitner, B.; Newman, E.; Nikolopoulos, E.; Roehrdanz, P.; Song, L.; Valencia-Rodriguez, D.; Yang, W.; Merow, C.; Silman, M.; VIllalobos, F.; Macklin, M.; Enquist, B. J.

10.1101/2025.05.21.654597 — ecology — Posted on 2025-05-26

1229 Mitochondrial fusion controls the development of specialized mitochondrial structure and metabolism in rod photoreceptor cells

Landowski, M.; Hagimori, R.; Gogoi, P.; Bhute, V. J.; Ikeda, S.; Takimoto, T.; Ikeda, A.

10.1101/2025.05.21.655403 — molecular biology — Posted on 2025-05-26

1230 Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington's disease

Baffuto, M.; Mätlik, K.; Ilyashov, I.; Siantoputri, M. E.; Chetia, H.; Harada, Y.; Sipos, E.; Darnell, P.; Kus, L.; Carroll, T.; Barrows, D.; Pressl, C.; Didkovsky, N.; Heintz, N.

10.1101/2025.05.21.653721 — neuroscience — Posted on 2025-05-26

1231 MRI mapping of hemodynamics in the human spinal cord

Hemmerling, K. J.; Hoggarth, M. A.; Sandhu, M. S.; Parrish, T. B.; Bright, M. G.

10.1101/2024.02.22.581606 — physiology — Posted on 2025-05-26

1232 Quantification of HER2-low and ultra-low expression in breast cancer specimens by quantitative IHC and artificial intelligence

Aidt, F.; Arbel, E.; Remer, I.; Ben-David, O.; Ben-Dor, A.; Rabkin, D.; Hoff, K.; Salomon, K.; Aviel-Ronen, S.; Nielsen, G.; Mollerup, J.; Jacobsen, L.; Tsalenko, A.

10.1101/2025.01.22.634230 — pathology — Posted on 2025-05-26

1233 Beyond accuracy, precision and TAE: Direct assay validation against product specification aligned with USP <1033>

Josipovic, D.

10.1101/2025.05.21.655192 — bioinformatics — Posted on 2025-05-26

1234 A novel expectation-maximization approach to infer general diploid selection from time-series genetic data

Fine, A. G.; Steinruecken, M.

10.1101/2024.05.10.593575 — genetics — Posted on 2025-05-26

1235 diplo-locus: A lightweight toolkit for inference and simulation of time-series genetic data under general diploid selection

Cheng, X.; Steinruecken, M.

10.1101/2023.10.12.562101 — genetics — Posted on 2025-05-26

1236 Comparative risk-assessment of spread of highly pathogenic avian influenza H5 viruses spread in French broiler and layer sectors.

Hautefeuille, C.; Munoz, F.; Dauphin, G.; Paul, M.; Peyre, M.; Goutard, F.

10.1101/2024.09.11.612235 — ecology — Posted on 2025-05-26

1237 tUbe net: a generalisable deep learning tool for 3D vessel segmentation

Holroyd, N. A.; Li, Z.; Walsh, C.; Brown, E. E.; Shipley, R. J.; Walker-Samuel, S.

10.1101/2023.07.24.550334 — microbiology — Posted on 2025-05-26

1238 Eukaryotic recombinases duplicated after divergence from known asgardarchaeal RadA: implications for the evolution of sex during eukaryogenesis

Matsuo, L.; Novak Vanclova, A. M. G.; Pomiankowski, A.; Lane, N.; Dacks, J. B.

10.1101/2025.05.23.655837 — evolutionary biology — Posted on 2025-05-26

1239 Mechanism of bridge-type phospholipid transfer by Atg2 for autophagosome biogenesis

Sakai, Y.; Matoba, K.; Kotani, T.; Hao, L.; Suzuki, K.; Kakuta, C.; Sugita, Y.; Osawa, T.; Nakatogawa, H.; Noda, N. N.

10.1101/2025.05.24.655882 — cell biology — Posted on 2025-05-26

1240 Efficient installation of heterozygous mutations in human pluripotent stem cells using prime editing

Suter, A.; Graham, A.; Kuah, J. Y.; Crisologo, J.; Gunatilake, C.; Sourris, K.; See, M.; Rossello, F. J.; Ramialison, M.; Vlahos, K.; Howden, S. E.

10.1101/2025.05.25.656043 — cell biology — Posted on 2025-05-26

1241 Xtricorder: A likelihood-enhanced self-rotation function and application to a machine-learning enhanced Matthews prediction of asymmetric unit copy number

McCoy, A. J.; Read, R. J.

10.1101/2025.05.22.655506 — molecular biology — Posted on 2025-05-26

1242 Spike inference from calcium imaging data acquired with GCaMP8 indicators

Rupprecht, P.; Rozsa, M.; Fang, X.; Svoboda, K.; Helmchen, F.

10.1101/2025.03.03.641129 — neuroscience — Posted on 2025-05-26

1243 On the Curvature and Relaxation of Microtubule Plus-endTips

Skora, T.; Wu, J.; Beckett, D.; Xue, W.; Voth, G. A.; Bidone, T. C.

10.1101/2025.05.23.655844 — biophysics — Posted on 2025-05-26

1244 Cryo-EM reveals open and closed Asgard chromatin assemblies

Ranawat, H. M.; Cajili, M. K. M.; Lopez-Barbosa, N.; Quail, T.; Dame, R. T.; Dodonova, S. O.

10.1101/2025.05.24.653377 — biophysics — Posted on 2025-05-26

1245 Medical Images as Biomarkers of Ageing - From Global and Local Patterns to Digital Twins

Mueller, T. T.; Starck, S.; Llalloshi, R.; Kaissis, G.; Ziller, A.; Rueckert, D.; Braren, R.

10.1101/2025.05.18.654705 — bioinformatics — Posted on 2025-05-26

1246 Vacuolar protein sorting-associated protein 1 (Vps1) has membrane constricting and severing abilities required for endosomal protein trafficking

Gopan, S.; Singh, G.; Swaminathan, U.; Pucadyil, T.

10.1101/2025.05.25.656005 — biochemistry — Posted on 2025-05-26

1247 The biogeography of evolutionary radiations on oceanic archipelagos

Bree, B.; Matthews, T. J.; Fernandez-Palacios, J. M.; Paroissin, C.; Triantis, K. A.; Whittaker, R. J.; Rigal, F.

10.1101/2024.10.07.616413 — evolutionary biology — Posted on 2025-05-26

1248 The intracellular vacuolar pathogen Coxiella burnetii promotes exocytosis in a type IVB secretion system dependent manner

Kumar, H.; Bhattacharya, A.; Benny, S.; Prakash, C.; Singh, N.; Baskaran, K.; Ganesan, S.

10.1101/2025.05.26.655767 — cell biology — Posted on 2025-05-26

1249 Mitochondria at synapse utilize fatty acids as a bioenergetic fuel source

Antunes, B. C.; Faria-Pereira, A.; Goncalves Ribeiro, J.; Costa Pinto, S.; Vaz, S. H. A.; Morais, V. A.

10.1101/2025.05.26.656116 — cell biology — Posted on 2025-05-26

1250 TRPV4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm's canal cells

Li, H.; Wong, C. A.; Siadat, S. M.; Perkumas, K. M.; Bertrand, J. A.; Overby, D. R.; Sulchek, T.; Stamer, W. D.; Ethier, C. R.

10.1101/2025.05.25.656000 — cell biology — Posted on 2025-05-26

1251 Multiplexed Targeted Spatial Mass Spectrometry Imaging Assays to monitor lipids and NAD+ metabolites in CD38 knockout mice exhibiting improved metabolism.

Schurman, C. A.; Bons, J.; Kumaar, P. V.; Fang, J.; Hormazabal, G. V.; Roberts, A.; Riley, R. R.; Tao, N.; Verdin, E.; Schilling, B.

10.1101/2025.05.25.655991 — cell biology — Posted on 2025-05-26

1252 Striatal Crosstalk Between Dopamine and Serotonin Systems

Liu, Y.; Traba, J. E.; Luscher, C.

10.1101/2025.03.28.645922 — neuroscience — Posted on 2025-05-26

1253 Belief updating in decision-variable space: past decisions with finer granularity attract future ones more strongly

Lee, H.; Lim, J.; Lee, S.-H.

10.1101/2024.08.20.608767 — neuroscience — Posted on 2025-05-26

1254 Endothelial lipase facilitates low-density lipoprotein (LDL) uptake in LDL receptor deficiency by a heparan sulfate proteoglycan-dependent mechanism.

White, O.; Aligabi, Z.; Burks, K. H.; Tang, J.; Stitziel, N. O.; Goldberg, I. J.; Remaley, A. T.; Lucero, D.

10.1101/2025.03.02.640965 — physiology — Posted on 2025-05-26

1255 Isoform-Specific Gene Regulation by Progesterone Receptors Drives Divergent Phenotypes in Breast Cancer Cells

Gillis, N. E.; Truong, T. H.; Diep, C. H.; Spartz, A.; Ostrander, J. H.; Lange, C. A.

10.1101/2025.05.19.654935 — cancer biology — Posted on 2025-05-26

1256 Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence

Rios, M. S.; Ripoll-Cladellas, A.; Omidi, F.; Ballouz, S.; Alquicira-Hernandez, J.; Oelen, R.; Franke, L.; van der Wijst, M. G. P.; Powell, J. E.; Mele, M.

10.1101/2024.11.06.622096 — bioinformatics — Posted on 2025-05-26

1257 Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using Single Cell RNA Sequencing

Saleem, M. U.; Sajid, H. A.; Shabbir, M. I.; Torres, A. R.; Rai, S. K.; Arshad, M. W.

10.1101/2025.01.13.632574 — bioinformatics — Posted on 2025-05-26

1258 Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model

Welz, B.; Pierotti, S.; Fitzgerald, T. W.; Thumberger, T.; Suzuki, R.; Watson, P.; Fuss, J.; Cordeiro da Trindade, T.; Defranoux, F.; Ferreira, M.; Naruse, K.; Loosli, F.; Gierten, J.; Wittbrodt, J.; Birney, E.

10.1101/2025.04.24.650462 — genetics — Posted on 2025-05-26

1259 The Gender Attractiveness Gap

Wassiliwizky, E.; Zietsch, B. P.; Ullen, F.

10.1101/2025.05.21.655261 — evolutionary biology — Posted on 2025-05-26

1260 Coevolution of phenological traits shapes plant-pollinator coexistence

Duchenne, F.; Dominguez-Garcia, V.; Molina, F.; Bartomeus, I.

10.1101/2024.08.08.607160 — ecology — Posted on 2025-05-26

1261 Not Extremely Plastic: Testing the Limits of Morphological Plasticity in Fungal Mycelia in Response to Soil Grazers

Aguilar-Trigueros, C. A.; Boddy, L.; Fricker, M.

10.1101/2025.01.14.632904 — ecology — Posted on 2025-05-26

1262 Antibiotic perturbation of the human gut phageome preserves its individuality and promotes blooms of virulent phages.

Pfeifer, E.; Humieres, C.; Lamy-Besnier, Q.; Plaza-Onate, F.; Denise, R.; Dion, S.; Condamine, B.; Touchon, M.; Ma, L.; Burdet, C.; Mentre, F.; Denamur, E.; Rocha, E.

10.1101/2025.02.07.636470 — microbiology — Posted on 2025-05-26

1263 High-fidelity but hypometric spatial localization of afterimages across saccades

Schweitzer, R.; Seel, T.; Raisch, J.; Rolfs, M.

10.1101/2025.05.04.652081 — neuroscience — Posted on 2025-05-26

1264 A case for slow-wave morphology as a functional biomarker of gastric disease

Dowrick, J. M.; Erickson, J. C.; Du, P.; Angeli-Gordon, T. R.

10.1101/2025.05.21.655419 — physiology — Posted on 2025-05-26

1265 Denoising Single-Cell RNA-Seq Data with a Deep Learning-Embedded Statistical Framework

Luo, Q.; Yu, Y.; Wang, T.

10.1101/2025.05.20.655104 — bioinformatics — Posted on 2025-05-26

1266 EEG-to-fMRI Prediction for Neurofeedback: Evaluating Regularized Regression and Clustering Approaches

De Feo, R.; Antipushina, E.; Tyukin, I.; Koush, Y.

10.1101/2025.05.20.654907 — bioinformatics — Posted on 2025-05-26

1267 Unified nonparametric analysis of single-molecule spatial omics data using probabilistic indices

Hawinkel, S.; Maere, S. G.; Yang, X.; Beeckman, T.; Motte, H.; Poelmans, W.

10.1101/2025.05.20.654270 — bioinformatics — Posted on 2025-05-26

1268 Advances in deep reinforcement learning enable better predictions of human behavior in time-continuous tasks

Haberland, S.; Ruge, H.; Frimmel, H.

10.1101/2025.05.20.655119 — bioinformatics — Posted on 2025-05-26

1269 CellReasoner: A reasoning-enhanced large language model for cell type annotation

Cao, G.; Shen, Y.; Wu, J.; Chao, H.; Chen, M.; Chen, D.

10.1101/2025.05.20.655112 — bioinformatics — Posted on 2025-05-26

1270 DeepAden: an explainable machine learning for substrate specificity prediction in nonribosomal peptide synthetases

Huang, J.; Ge, L.; Wu, Y.; Gao, Q.; Li, P.; Wu, J.; Zhang, H.; Qin, Z.

10.1101/2025.05.21.655435 — bioinformatics — Posted on 2025-05-26

1271 Comparative genomics and transcriptomics on salt tolerance of Vigna luteola

Iki, Y.; Wang, F.; Ito, K.; Wakatake, T.; Tanoi, K.; Naito, K.

10.1101/2025.05.21.653682 — genomics — Posted on 2025-05-26

1272 Social interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback

Robertson, A. J.; Kerr, B.; Feder, A. F.

10.1101/2025.05.20.655113 — evolutionary biology — Posted on 2025-05-26

1273 Synchronous Miocene radiations and geographic-dependent diversification of pantropical Xylopia (Annonaceae)

Nge, F. J.; Johnson, D. M.; Murray, N. A.; Holzmeyer, L.; Floyd, K.; Stull, G.; Soule, V.; Sepulchre, P.; Tardif, D.; Rodrigues Vaz, C.

10.1101/2025.05.21.655441 — evolutionary biology — Posted on 2025-05-26

1274 Impact of Group Size and Habitat Disturbance on Parasitic Infection in Free-ranging Proboscis Monkeys

Fitri-Suhaimi, M. N.; Frias, L.; Zimmermann, E.; Lambut, P.; Tangah, J.; Bernard, H.; Subbiah, V. K.; Matsuda, I.

10.1101/2025.05.21.655443 — ecology — Posted on 2025-05-26

1275 The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

Magalhaes Pinto, M.; Malengier-Devlies, B.; Seuzaret, G.; Ahlback, A.; Becker, S.; Patatsos, K.; Drakoulis, G.; Karjalainen, J.; Ruedl, C.; Voehringer, D.; Bain, C.; Emmerson, E.; Schonfeldova, B.; Zec, K.; Udalova, I. A.; Simakou, T.; MacDonald, L.; Kurowska-Stolarska, M.; Miotla-Zarebska, J.; Vincent, T.; Ricci, R.; Erbs, E.; Barrington, J.; McColl, B.; Neag, G.; Kemble, S.; Mahony, C.; Croft, A.; Boon, L.; Migotsky, N.; Killian, M.; Brahim, O. B.; Uderhardt, S.; Gallerand, A.; IVANOV, S.; Gentek, R.

10.1101/2025.05.21.655269 — immunology — Posted on 2025-05-26

1276 Non-destructive, high-resolution T cell characterization and subtyping via deep-ultraviolet microscopy

Gorti, V.; Serafini, C. E.; Silva Trenkle, A. D.; McCubbins, K.; LeCompte, I.; Kwong, G. A.; Robles, F. E.

10.1101/2025.05.20.655120 — immunology — Posted on 2025-05-26

1277 Noninvasive focal gene transfer of chemogenetic proteins in the primate brain

Corigliano, M. R.; Parks, T. V.; Guretse, S. S.; Letica, L.; Zimmermann Rollin, I.; Pell, S. K. A.; Campos, V. P.; Szczupak, D.; Schaeffer, D. J.

10.1101/2025.05.21.655304 — neuroscience — Posted on 2025-05-26

1278 Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation

Zhu, C.; Lucero, E.; Patel, R.; Makita, T.; Wang, J. J.; Cao, Y.; Rockman, H. A.; Shivkumar, K.

10.1101/2025.05.20.655085 — physiology — Posted on 2025-05-26

1279 Honeybees collect pollen from the buzz-pollinated flowers of invasive Solanum elaeagnifolium in Northern Greece

Kantsa, A.; Nakas, G.; Kariyat, R. R.; Lambert, H.; Petanidou, T.; De Moraes, C. M.; Mescher, M. C.

10.1101/2025.05.13.648936 — ecology — Posted on 2025-05-26

1280 The metabolic mechanisms underlying zooplankton derived dissolved organic matter chemical properties

Nuruddin, M. F.; Ding, H.; WU, L.

10.1101/2024.10.27.620474 — molecular biology — Posted on 2025-05-26

1281 Changes in the Public IgM Repertoire and Its Idiotypic Connectivity in Alzheimer's Disease and Frontotemporal Dementia

Pashova-Dimov, S.; Petrov, P.; Karachanak-Yankova, S.; Belezhanska, D.; Zhelev, Y.; Mehrabian, S.; Traykov, L.; Toncheva, D.; Pashov, A.

10.1101/2024.07.15.603559 — immunology — Posted on 2025-05-26

1282 Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing

Chen, D.; Isakova, A.; Wan, Z. J.; Wagner, M. J.; Wu, Y.; Zhao, B. S.

10.1101/2025.02.13.638129 — neuroscience — Posted on 2025-05-26

1283 High-fidelity but hypometric spatial localization of afterimages across saccades

Schweitzer, R.; Seel, T.; Raisch, J.; Rolfs, M.

10.1101/2025.05.04.652081 — neuroscience — Posted on 2025-05-26

1284 Contribution of statistical learning to learning from reward feedback

Yazdanpanah, A.; Wang, C.; Trepka, E.; Soltani, A.

10.1101/2024.04.27.591445 — neuroscience — Posted on 2025-05-26

1285 RGAST: A Relational Graph Attention Network for Multi-Scale Cell-Cell Communication Inference from Spatial Transcriptomics

Gong, Y.; Yu, Z.

10.1101/2024.08.09.607420 — bioinformatics — Posted on 2025-05-26

1286 Sequence alignment with k-bounded matching statistics

Mäklin, T.; Alanko, J. N.; Biagi, E.; Puglisi, S. J.

10.1101/2025.05.19.654936 — bioinformatics — Posted on 2025-05-26

1287 Exploring the Impact of Volumetric Additive Manufacturing of Photo-crosslinkable Gelatin on Mesenchymal Stromal Cell Behavior and Differentiation

Pien, N.; Bogaert, B.; Meeremans, M.; Popovici, C.-S.; Dubruel, P.; De Schauwer, C.; Van Vlierberghe, S.

10.1101/2025.02.17.638591 — bioengineering — Posted on 2025-05-26

1288 Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

Gao, Y.; Fang, C.; Zhou, B.; Hameed, H. M. A.; Sun, C.; Tian, X.; He, J.; Han, X.; Zhang, H.; Li, J.; Ju, J.; Chen, X.; Zhong, N.; Ma, J.; Xiong, X.; Zhang, T.

10.1101/2024.02.24.581832 — microbiology — Posted on 2025-05-26

1289 Faroese Whole Genomes Provide Insight into Ancestry and Recent Selection

Hamid, I.; Mortensen, O.; Refoyo-Martinez, A.; Lydersen, L. N.; Emde, A.-K.; Hendershott, M.; Apol, K. D.; Andorsdottir, G.; Meisner, J.; Wasik, K. A.; Racimo, F.; Castel, S. E.; Gregersen, N. O.

10.1101/2025.05.20.655212 — genetics — Posted on 2025-05-26

1290 Host usage in Aedes aegypti collected from Houston, Texas and Phoenix, Arizona using whole mosquito third-generation sequencing blood meal analysis

Ciomperlik, B. A.; Burgess, E. R.; Sanscrainte, N. D.; Mosore, M.-t.; Townsend, J.; Will, J.; Busser, N.; Estep, A.

10.1101/2025.05.19.654806 — ecology — Posted on 2025-05-26

1291 CD163+/Dab2+ Macrophages Alleviate Cardiac Hypertrophy via Nrg2/ErbB4-Mediated Mitochondrial Reprogramming

Zhu, Q.; Liao, S.; Zhou, Y.; Zhou, R.; Dong, M.

10.1101/2025.05.22.655661 — cell biology — Posted on 2025-05-26

1292 IL-17A-driven Macrophage Disorder Promotes Plaque Instability in Psoriatic Atherosclerosis

Dong, C.; Wang, J.; Lin, J.-M.; Lu, X.; Zhu, J.; Lin, L.; Zhou, L.; Liu, F.; Wu, D.; Zhu, X.; Sun, J.; Xu, J.; Zhu, N.; Wu, W.; Tan, J.; Du, J.

10.1101/2025.05.21.654491 — cell biology — Posted on 2025-05-26

1293 Mapping early patterning events in human neural development usingan in-vitro microfluidic stem cell model

Rathore, G. S.; Ankjaer, M.; Rifes, P.; Hanninen, E.; Calleja, F. S.; Rusimbi, C.; Kajtez, J.; Nygaard, A. H.; Piilgaard, L. S.; Dubonyte, U.; Norgaard, Z. A.; Christensen, J. B.; Egerod, K. L.; Camp, J. G.; Pers, T.; Treutlein, B.; Kirkeby, A.

10.1101/2025.05.23.655442 — neuroscience — Posted on 2025-05-26

1294 Large protein databases reveal structural complementarity and functional locality

Szczerbiak, P.; Szydlowski, L. M.; Wydmanski, W.; Renfrew, P. D.; Koehler Leman, J.; Kosciolek, T.

10.1101/2024.08.14.607935 — bioinformatics — Posted on 2025-05-26

1295 Phylogenomic evidence for host specialization and genetic divergence in OsHV-1 infecting Magallana gigas and Ostrea edulis

Pelletier, C.; Chevignon, G.; Faury, N.; Arzul, I.; Garcia, C.; Chollet, B.; Renault, T.; Morga, B.; Jacquot, M.

10.1101/2023.08.23.554398 — evolutionary biology — Posted on 2025-05-26

1296 The paternally expressed genes in endosperm comfort the kinship theory to explain imprinting in A. lyrata.

Le veve, A.; Iltas, O.; Dutheil, J.; Lafon Placette, C.

10.1101/2024.08.01.606153 — evolutionary biology — Posted on 2025-05-26

1297 KIF5B and Dynein regulate adhesion-dependent Golgi organization and microtubule acetylation

Chakraborty, A.; Pitke, S.; BR, R.; Buwa, N.; Dasgupta, A.; Behera, R.; Jayakrishnan, M.; Balasubramanian, N.

10.1101/2025.05.11.653231 — cell biology — Posted on 2025-05-26

1298 A machine learning model for the proteome-wide prediction of lipid-interacting proteins

Chou, J. C.-C.; Chatterjee, P.; Decosto, C. M.; Dassama, L. M. K.

10.1101/2024.01.26.577452 — bioinformatics — Posted on 2025-05-26

1299 Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onward

Dupas, M.-C.; Vincenti-Gonzalez, M. F.; Dhingra, M.; Guinat, C.; Vergne, T.; Wint, G. W.; Hendrickx, G.; Marsboom, C.; Gilbert, M.; Dellicour, S.

10.1101/2024.11.15.623755 — ecology — Posted on 2025-05-25

1300 Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

Sergounioti, A.; Alonaris, E.; Rigas, D.

10.1101/2025.04.27.650828 — cell biology — Posted on 2025-05-25

1301 Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons

Clay, K. B.; Medlock-Lanier, T.; Grimes, R. N.; Oke, O. O.; Filipov, N.; Roberts-Galbraith, R. H.

10.1101/2025.05.23.655781 — neuroscience — Posted on 2025-05-25

1302 Task-relevant cognitive maps in episodic memory

Rau, E. M. B.; Heinen, R.; Herweg, N. A.; Patai, E. Z.; Kobelt, M.; Ahmadi, K.; Axmacher, N.

10.1101/2025.05.23.655754 — neuroscience — Posted on 2025-05-25

1303 Age and Alzheimer's disease affect functional connectivity along separate axes of functional brain organization

Rittmo, J.; Franzmeier, N.; Strandberg, O.; Chauveau, L.; Satterthwaite, T. D.; Wisse, L. E.; Spotorno, N.; Behjat, H. H.; Dehsarvi, A.; van Westen, D.; Anijärv, T. E.; Palmqvist, S.; Janelidze, S.; Stomrud, E.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Hansson, O.; Vogel, J. W.

10.1101/2025.05.22.655469 — neuroscience — Posted on 2025-05-25

1304 Inhibition and Updating Share Common Resources: Bayesian Evidence from Signal Detection Theory and Drift Diffusion Model

Sun, Y.; Lin, Y.; Han, S.

10.1101/2024.11.06.622265 — neuroscience — Posted on 2025-05-25

1305 Cycles in Seizure Duration and Their Underlying Dynamics in the Tetanus Toxin Rat Model

Zarei Eskikand, P.; Kazemi, S.; Cook, M.; Burkitt, A. N.; Grayden, D. B.

10.1101/2024.11.27.625789 — neuroscience — Posted on 2025-05-25

1306 Long-term stability of dominance hierarchies in a wild parrot with fission-fusion dynamics

Penndorf, J.; Farine, D. R.; Martin, J. M.; Aplin, L. M.

10.1101/2024.05.15.594429 — animal behavior and cognition — Posted on 2025-05-25

1307 ChemBERTaPolyPharm: Modeling polypharmacy side effects with ChemBERTa and PubMed Encoders

Gromova, A. A.; Maida, A. S.

10.1101/2025.05.20.655109 — bioinformatics — Posted on 2025-05-25

1308 Engineering of interconnected microcapillary networks at the mesoscale via magnetic assembly of endothelial-cell 'seeds'.

Rojek, K.; Wrzos, A.; Maiullari, F.; Gizynski, K.; Ceraolo, M. G.; Bearzi, C.; Rizzi, R.; Szymczak, P.; Guzowski, J.

10.1101/2025.05.20.655072 — bioengineering — Posted on 2025-05-25

1309 Multidirectional alignment of collagen fibers to guide cell orientation in 3D-printed tissue

Singhal, D.; Christakopoulos, F.; Brunel, L. G.; Borkar, S.; Doulames, V. M.; Myung, D.; Fuller, G. G.; Heilshorn, S. C.

10.1101/2025.05.20.654730 — bioengineering — Posted on 2025-05-25

1310 Activity-based probes and chemical proteomics reveal the potential of targeting HMGCS1 for cancer therapy

Yi, S. A.; Liang, S.; Rao, Y.; Ordureau, A.; Lewis, J.; An, H.

10.1101/2025.05.21.655359 — biochemistry — Posted on 2025-05-25

1311 RNA-sequencing Strain-specific Genome Alignment Increases Differential Expression Findings in Comparison of C57BL/6J and DBA/2J Nucleus Accumbens

Gnatowski, E.; Zeliff, D.; Dozmorov, M. G.; Miles, M. F.

10.1101/2025.05.25.656014 — genomics — Posted on 2025-05-25

1312 Genome assembly and annotation of the naked mole rat Heterocephalus glaber reared in Japan

Toga, K.; Oka, K.; Tanaka, H.; Itoh, T.; Toyoda, A.; Bono, H.; Miura, K.

10.1101/2025.05.20.654782 — genomics — Posted on 2025-05-25

1313 A spatially targeted metric of potential koala populations based on Bayesian Networks for conservation management

Muriuki, G.; Mooney, S.; Castiglione, M.; Davis, J.; Pitchforth, J.; Johnson, S.; Duwalage, K. I.; Mengersen, K.; Wu, P. P.-Y.

10.1101/2025.05.20.655061 — ecology — Posted on 2025-05-25

1314 The landscape and consequences of transcription stress

Aqeilan, R. I.; Hidmi, O.; Oster Flayshman, S.; Shatleh, D.; Monin, J.

10.1101/2025.05.25.655982 — molecular biology — Posted on 2025-05-25

1315 CAMK2D causes heart failure in RBM20 cardiomyopathy

van den Hoogenhof, M. M.; Duran, J.; Britto-Borges, T.; Kemmling, E.; Konrad, L.; Lennermann, D. C.; Hartmann, J.; Schraft, L.; Kornienko, J.; Bock, T.; Krueger, M.; Dieterich, C.; Steinmetz, L. M.; Dewenter, M.; Backs, J.

10.1101/2025.05.23.655557 — molecular biology — Posted on 2025-05-25

1316 Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes

Lansink, L. I. M.; Walther, L.; Longmore, S.; Jones, M.; Dowle, A.; Faria, J. R.

10.1101/2025.05.24.654301 — molecular biology — Posted on 2025-05-25

1317 Developing terrestrial environmental DNA sampling methods for detecting arboreal invasive reptiles: a case study of the green anole in the Ogasawara Island, Japan

Tsuji, S.; Murakami, Y.; Toda, M.; Yagami, Y.; Ashizawa, K.; Nishiwaki, T.; Yamamoto, N.

10.1101/2025.05.24.655731 — molecular biology — Posted on 2025-05-25

1318 Dual Metabolic Blockade by Metformin and Dichloroacetate Induces Lethal Energy Crisis in Chemoresistant NSCLC

Tang, J.; Yang, R.

10.1101/2025.05.20.654286 — immunology — Posted on 2025-05-25

1319 Fluctuation Test with Phenotypic Switching: A Unified Stochastic Approximation Framework

Hlubinova, A.; Bokes, P.; Singh, A.

10.1101/2025.05.20.655090 — systems biology — Posted on 2025-05-25

1320 Bursty Gene Expression in Single Cells and Expanding Populations: A Discrete Approach

Poljovka, J.; Zabaikina, I.; Bokes, P.; Singh, A.

10.1101/2025.05.20.655093 — systems biology — Posted on 2025-05-25

1321 AI-Guided Discovery and Optimization of Antimicrobial Peptides Through Species-Aware Language Model

Bae, D.; Kim, M.; Seo, J.; Nam, H.

10.1101/2025.05.20.654992 — bioinformatics — Posted on 2025-05-25

1322 A statistical model for quantitative analysis of single-molecule footprinting data

Ozonov, E. A.; Gaspa-Toneu, L.; Peters, A.

10.1101/2025.05.20.655044 — bioinformatics — Posted on 2025-05-25

1323 Unravelling the constrained cell growth in engineered living materials

Sun, S.-S.; Ding, C.-C.; Yu, H.-Y.; Yuan, X.-Z.; Wang, S.-G.; Xia, P.-F.

10.1101/2025.05.21.655284 — bioengineering — Posted on 2025-05-25

1324 Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras

Maiocchi, A.; Abel, A.-C.; Basellini, M.; Perez-Pena, H.; Boiarska, Z.; Ferrandi, E. E.; Kozicka, Z.; Fasano, V.; Pieraccini, S.; Cappelletti, G.; Steinmetz, M. O.; Passarella, D.; Prota, A. E.

10.1101/2025.05.22.655572 — biochemistry — Posted on 2025-05-25

1325 Allosteric Control of Super-Agonism in a Ligand-Gated Ion Channel

Viscarra, F.; Minguez, T.; Bermudez-Diaz, I.; Biggin, P. C.

10.1101/2025.05.23.655750 — biochemistry — Posted on 2025-05-25

1326 Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5

Goetzke, F. W.; Bernard, S. M.; Ju, C.-W.; Pollock, J.; DeMeester, K. E.; Gross, J.; Simon, G. M.; He, C.; Melillo, B.; Cravatt, B. F.

10.1101/2025.05.25.655995 — biochemistry — Posted on 2025-05-25

1327 Unmasking Human T Cell Receptor Germline Diversity: 335 Novel Alleles Identified in 47 Pangenome Reference Individuals Using the gAIRR Suite

Yang, Y.-H.; Yao, C.-Y.; Lin, M.-J.; Huang, K.-T.; Lin, Y.-H.; Chiu, I.-H. C.; Lai, S.-K.; Chen, C.-Y.; Yang, Y.-C.; Hsu, C.-L.; Hsu, J. S.; Chen, C.-Y.; Chen, P.-L.

10.1101/2025.05.24.655452 — genomics — Posted on 2025-05-25

1328 Genome-wide screen uncovers novel host factors for L-A virus maintenance and a mutualistic-symbiosis relationship in yeast

Hsiao, W.-Y.; Yeh, C.-S.; Liu, H.-I.; Tung, L.; Chang, T.-H.

10.1101/2025.05.20.655038 — genomics — Posted on 2025-05-25

1329 Functional bottlenecks can emerge from non-epistatic underlying traits

Schulte, A. O.; Alqatari, S.; Rossi, S.; ZAMPONI, F.

10.1101/2025.05.20.655048 — evolutionary biology — Posted on 2025-05-25

1330 Evolutionary responses to historic drought across the range of scarlet monkeyflower

Sheth, S. N.; Albano, L. J.; Blanchard, C.; Cook, E. J.; Diaz, R.; Gomez-Vega, X.; Kutella, K.; Moazed, M.; Patel, M.; Prange, J.; Ramadoss, N.; Regan, A.; Riley, A.; Rivas Hernandez, M.; Rojas, J.; Strebler, M.; Verma, A.; Villano, L.; Waits, J.; Wang, D.; Wilborn-Pilotte, O.; Diez, J.; Flores-Renteria, L.; Sexton, J.; Muir, C. D.

10.1101/2025.05.20.655098 — evolutionary biology — Posted on 2025-05-25

1331 Escaping inbreeding: the demographic path to genetic recovery

Ahrens, C. W.; Miller, A. D.; Silver, L. W.; Mclennan, E. A.; Hogg, C. J.; Weeks, A. R.

10.1101/2025.05.20.655063 — evolutionary biology — Posted on 2025-05-25

1332 Diversity and Community Structure of Collembola (Hexapoda) across sites and microhabitats in the Bula Protected Area, a UNESCO-Listed Hyrcanian Forest at the Crossroads of Two Biodiversity Hotspots (Iran).

Tully, T.; Shayanmehr, M.; Yoosefi Lafooraki, E.; Ghajar Sepanlou, M.; D'Haese, C.

10.1101/2025.05.20.650270 — ecology — Posted on 2025-05-25

1333 Diverse behavioural responses of vampire bats to human disturbance revealed by state-space modelling of sparse GPS data.

Cardoso Ribeiro, R. C.; Zariquiey, C. M.; Chavez, W.; Pillaca Rodriguez, K.; Clavijo Manuttupa, J.; Risco Huiman, M. A.; Zuniga Villafuerte, R.; Campana Quintanilla, W.; Medrano-Uchuya, N.; French, H.; Czyzewski, J.; Shiva, C.; Falcon, N.; Valderrama, W.; Walsh, D. P.; Rocke, T. E.; Matthiopoulos, J.; Streicker, D. G.

10.1101/2025.05.20.655023 — ecology — Posted on 2025-05-25

1334 Creatine synthesis is a tumor suppressor pathway hypostatic to one-carbon metabolism

Leung, N. Y. T.; Yee, T. M.; AminiTabrizi, R.; Bhalla, R.; Ang, N.; Lu, L.; Chan, C. Y.; Lian, D. W. Q.; Lim, M. Y.; Paulo, J. A.; Wu, W.; Shah, H.; Wang, L. W.

10.1101/2025.05.23.655758 — molecular biology — Posted on 2025-05-25

1335 Intestinal Stem Cells Retain an Epigenetic Memory of Prior Inflammation

Hamdan, F. H.; Perez, I.; Smith, H.; Kossick, K.; Edwinson, A.; de Hoyos-Vega, J. M.; Gonzalez, M.; Chiang, D.; Klatt, E.; Rumer, K.; Perez Pachon, M.; Sagstetter, M.; Friton, J.; Kammer, E.; English, A.; Chini, L. C. S.; Carnahan, J. F.; Baca, N. A.; Mopuri, R.; Bhagwate, A.; Raffals, L. E.; Sun, Z.; Grover, M.; Revzin, A.; Faubion, W. A.; Druliner, B. R.

10.1101/2025.05.24.655923 — molecular biology — Posted on 2025-05-25

1336 From Microscale to Microbial Insights: Validating High-Throughput Microvolume Extraction Methods (HiMEx) for Microbial Ecology

Ghotbi, M.; Ghotbi, M.; DAgostino, E.; Kanitz, M.; Needham, D. M.

10.1101/2025.05.25.655987 — molecular biology — Posted on 2025-05-25

1337 MPK3 mediated phosphorylation of WRKY48 down regulates CIPK6 expression during PstDC3000 challenge in Arabidopsis

Singh, N.; Chattopadhyay, D.

10.1101/2025.05.21.655431 — molecular biology — Posted on 2025-05-25

1338 Source tracking of larval bacterial community of Pacific white shrimp across the developmental cycle: ecological insights for microbial management and pathogen prevention in larviculture

Zhang, F.; Chen, H.; Yu, J.; Chen, R.; Zhang, D.; Chen, C.; Wang, K.

10.1101/2025.05.25.655974 — microbiology — Posted on 2025-05-25

1339 Fat-rich diet reprograms intrapulmonary neutrophils to boost tissue-specific antitumor immunity

Wang, Y.; Zhang, J.; Li, Y.; Wang, T.; Wang, L.; Miao, Y.; Chang, C.-W.; Liu, Y.; Huang, Z.; Yao, Z.; Xu, H.; Zhou, Q. D.; Wang, L.; Yao, Y.

10.1101/2025.05.20.655047 — immunology — Posted on 2025-05-25

1340 Laquinimod treatment attenuates EAU by inhibiting both the inductive and effector phases in an APC-dependent manner

Xu, B.; Mattapallil, M. J.; Jia, X.; Tang, J.; Horai, R.; Caspi, R. R.; Gery, I.

10.1101/2025.05.20.654165 — immunology — Posted on 2025-05-25

1341 Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs

Ho, G.; Santos, A.; Fields, J.; Rosato, P. C.; Turk, M. J.; Steinmetz, N.; fiering, S.

10.1101/2025.05.20.655082 — immunology — Posted on 2025-05-25

1342 Live imaging of bacterial actin MreBs causing helicity switching of a minimal synthetic cell

Tanaka, Y.; Kiyama, H.; Morimoto, Y. V.; Miyata, M.

10.1101/2025.05.23.655722 — biophysics — Posted on 2025-05-25

1343 Non-Canonical RNA Binding of Human La-related Protein 6

Gordon, B. H.; Ogunkunle, V. S.; Silvers, R.

10.1101/2025.05.22.652967 — biophysics — Posted on 2025-05-25

1344 Siibra: A software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources

Dickscheid, T.; Gui, X.; Simsek, A. N.; Schiffer, C.; Mangin, J.-F.; Leprince, Y.; Jirsa, V.; Bjaalie, J. G.; Leergaard, T. B.; Bludau, S.; Amunts, K.

10.1101/2025.05.20.655042 — bioinformatics — Posted on 2025-05-25

1345 Rapid expression of pyruvate decarboxylase from Zymomonas mobilis in E. coli BL21 LysY/Iq

Jilani, S. B.; Olson, D. G.

10.1101/2025.05.25.654064 — biochemistry — Posted on 2025-05-25

1346 Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia

Pearson, A. C.; Yampolsky, L. Y.

10.1101/2025.05.21.655400 — biochemistry — Posted on 2025-05-25

1347 SPITROBOT-2 advances time-resolved cryo-trapping crystallography to under 25 ms

Spiliopoulou, M.; Hatton, C. E.; Kollewe, M.; Leimkohl, J.-P.; Schikora, H.; Tellkamp, F.; Mehrabi, P.; Schulz, E. C.

10.1101/2025.05.23.655289 — biochemistry — Posted on 2025-05-25

1348 Distinct classes of antidepressants commonly act to shape pallidal structure and function in mice

Abe, Y.; Sugiura, Y.; Maeda, R.; Taira, S.; Yoshida, K.; Ibi, D.; Moritoh, S.; Hashimoto, K.; Yagishita, S.; Tanaka, K. F.

10.1101/2024.09.23.614626 — neuroscience — Posted on 2025-05-25

1349 Analysis of spectral and photosynthetic response variations of Cystoseira spp. exposed to Chromium

Varini, F.; Penna, M.; Varghese, D.; Mancuso, F. P.; Marcelli, M.

10.1101/2025.05.20.655136 — ecology — Posted on 2025-05-25

1350 Poultry-Associated Nitrofurantoin-Resistant and Pre-Resistant Escherichia coli Clones are Found in Multiple Countries and One-Health Compartments

Sealey, J.; Astley, B.; Mounsey, O.; Avison, M. B.

10.1101/2024.10.20.619276 — microbiology — Posted on 2025-05-25

1351 The neuroreceptors and transporters underlying spontaneous brain activity

Nakuci, J.; Bansal, K.

10.1101/2024.12.06.627265 — neuroscience — Posted on 2025-05-25

1352 Advanced neural activity mapping in brain organoids via field potential imaging with ultra-high-density CMOS microelectrodes.

Yokoi, R.; Matsuda, N.; Ishibashi, Y.; Suzuki, I.

10.1101/2025.05.24.655914 — neuroscience — Posted on 2025-05-25

1353 Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation

Wood, C. P.; Shin, Y.; Balaguer, M. G.; Campo, P.; Dirik, S.; Montoya, B. A.; Cook, G. M. R.; Palermo, G. M.; Naghshineh, P. K.; Morgan, A.; Rahman, S. R. M. U.; Palmer, A. A.; Telese, F.; de Guglielmo, G.

10.1101/2025.05.20.655167 — animal behavior and cognition — Posted on 2025-05-25

1354 Off-target interaction of the amyloid PET imaging tracer PiB with acetylcholinesterase

Granzotto, A.; Fullone, R.; Miccoli, L.; Bomba, M.; Di Marzio, C.; Delli Pizzi, S.; Floresta, G.; Sensi, S. L.

10.1101/2025.05.16.654428 — neuroscience — Posted on 2025-05-25

1355 Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages.

Hioki, K. A.; Liang, X.; Lynch, A. C.; Ranjan, R.; Pobezinskaya, E. L.; Pobezinsky, L. A.

10.1101/2025.05.20.655135 — immunology — Posted on 2025-05-25

1356 Genetic background influences the heterogeneous phenotypes driven by the MAFAS64F MODY variant in male mice

Loyd, Z.; Lee, D.; Maurer, M.; Liu, J.-H.; Guo, M.; Reynolds, G.; Magnuson, M. A.; Cartailler, J.-P.; Stein, R.; Cha, J.

10.1101/2025.05.20.653758 — physiology — Posted on 2025-05-25

1357 Improved open modification searching via unified spectral search with predicted libraries and enhanced vector representations in ANN-SoLo

Arab, I.; Laukens, K.; Bittremieux, W.

10.1101/2025.05.20.655174 — bioinformatics — Posted on 2025-05-25

1358 Alternating 2D and 3D Culture Reduces Cell Size and Extends the Lifespan of Placenta-Derived MSCs

Pan, Y.; Han, L.; Yang, Y.; Wu, X.; Wang, A.; Xie, L.; Zhu, W.; Wang, S.; Lei, Y.

10.1101/2025.05.20.655182 — bioengineering — Posted on 2025-05-25

1359 Storm in a bottle: An experimental investigation of how extreme precipitation impacts phytoplankton communities

Barth, A. J.; Pinckney, J.; Krask, J.; Smith, E.; Stone, J.

10.1101/2025.05.20.655176 — ecology — Posted on 2025-05-25

1360 Signaling of trans-saccadic prediction error by foveal neurons of the monkey superior colliculus

Zhang, T.; Bogadhi, A.; Hafed, Z. M.

10.1101/2025.03.02.641039 — neuroscience — Posted on 2025-05-25

1361 Using Virtual Patients to Evaluate Dosing Strategies for Bispecifics with a Bell-Shaped Efficacy Curve

Gevertz, J. L.; Kareva, I.

10.1101/2025.05.20.655186 — systems biology — Posted on 2025-05-25

1362 Saliva-based Biomarkers for Predicting Gastric Cancer

Arora, A.; Raghava, G. P. S.

10.1101/2025.05.20.655204 — bioinformatics — Posted on 2025-05-25

1363 Variation in temperature but not diet determines the stability of latitudinal clines in tolerance traits and their plasticity

Walter, G. M.; Chakraborty, A.; Cockerell, F.; Kellermann, V.; Hall, M. D.; White, C. R.; Sgro, C. M.

10.1101/2025.05.20.655196 — evolutionary biology — Posted on 2025-05-25

1364 Marginal zone and follicular B cells respond differently to TLR4 and TLR9 stimulation

Makkar, H.; Remick, S.; Roy, S.; Zangle, T. A.; Roy, K.

10.1101/2025.05.20.655194 — immunology — Posted on 2025-05-25

1365 Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice

Zhang, C.; Yang, D.; Suzuki, H.; Chen, J.; Wang, J.; Ye, M.; Zhou, J.; Zeng, Q.; Bai, M.; Lin, M.-J.; Lee, J.; Zhu, H.; Hoshida, Y.; Zeng, X.

10.1101/2025.05.20.655199 — physiology — Posted on 2025-05-25

1366 Differential conformational expansion of Nup98-HOXA9 oncoprotein in micro- and macrophases

Ruan, H.; Dillenburg, R.; Wittmann, S.; Girard, M.; Lemke, E. A.

10.1101/2025.05.21.655138 — biophysics — Posted on 2025-05-25

1367 Partitioned Multi-MUM finding for scalable pangenomics

Shivakumar, V. S.; Langmead, B.

10.1101/2025.05.20.654611 — bioinformatics — Posted on 2025-05-25

1368 Likelihood-based fine-tuning of protein language models for few-shot fitness prediction and design

Hawkins-Hooker, A.; Surana, S.; Simons, J.; Kmec, J.; Bent, O.; Duckworth, P.

10.1101/2024.05.28.596156 — bioinformatics — Posted on 2025-05-25

1369 Residue conservation and solvent accessibility are (almost) all you need for predicting mutational effects in proteins

Tsishyn, M.; Hermans, P.; Pucci, F.; Rooman, M.

10.1101/2025.02.03.636212 — bioinformatics — Posted on 2025-05-25

1370 Meta-Analyzed Atopic Dermatitis Transcriptome (MAADT) is strongly correlated with disease activity, and consistent with therapeutic effects

Li, X.; He, W.; Zhang, Y.; Page, K.; Hyde, C.; Maciejewski, M.

10.1101/2022.05.24.493180 — bioinformatics — Posted on 2025-05-25

1371 Engineering orthogonal and synergistic modules in marine bacteria for efficient upcycling of lignin-derived carbon

Wei, Y.; Gong, B.; Chen, P.-R.; Yuan, X.-Z.; Wang, S.-G.; Xia, P.-F.

10.1101/2025.05.20.655217 — bioengineering — Posted on 2025-05-25

1372 Perivascular matrix densification dysregulates angiogenesis and activates pro-inflammatory endothelial cells

Xia, J.; Wang, W.; Jacobs, K.; Lin, D.; Jarman, E.; Matera, D.; Loesel, K.; Davison, C.; Hiraki, H.; Tan, X.; Shikanov, E.; Kent, R.; Parent, C.; Fan, X.; Shikanov, A.; Kutys, M. L.; Baker, B.

10.1101/2025.05.20.655215 — bioengineering — Posted on 2025-05-25

1373 De novo genome assemblies of threatened Asian hornbills (Bucerotidae) reveal declining population trajectories during the late Pleistocene

Pawar, P. Y.; Krishnan, G.; Naniwadekar, R.; Joshi, J.

10.1101/2025.05.20.655227 — genomics — Posted on 2025-05-25

1374 Diffusion Neuroimaging of Speech Acquisition in Infants

Liu, F.; Liu, J.; Gu, J.; Wang, Y.; Cai, X.; Wang, Z.; Wu, H.; Feng, J.; Zhang, H.; Shen, D.

10.1101/2025.05.23.655876 — neuroscience — Posted on 2025-05-25

1375 From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models

Pugh, C. W. J.; Nunez-Valencia, P. G.; Dias, M.; Frazer, J.

10.1101/2025.05.20.655154 — bioinformatics — Posted on 2025-05-24

1376 High-Resolution Spatial Mapping of Electrocorticographic Activities with a 4096-Channel, Multiplexed Flexible Thin-Film Transistor Array

Sheng, X.

10.1101/2024.08.18.608446 — bioengineering — Posted on 2025-05-25

1377 Can ancient DNA and other forms of time-sampled data aid in the inference of negative frequency dependent selection?

Soni, V.

10.1101/2025.05.24.655935 — genomics — Posted on 2025-05-24

1378 Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif

Biga, V.; Miller, A.; Kamath, A.; Mak, Y. Q. P.; Adamson, A. D.; Marinopoulou, E.; Francois, P.; Papalopulu, N.; Manning, C. S.

10.1101/2025.05.22.655498 — developmental biology — Posted on 2025-05-24

1379 Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens

Regalado, S. G.; Qiu, C.; Lalanne, J.-B.; Martin, B. K.; Duran, M.; Trapnell, C.; Keith, A.; Domcke, S.; Shendure, J.

10.1101/2025.05.23.655669 — developmental biology — Posted on 2025-05-24

1380 A Forebrain Hub for Cautious Actions via the Midbrain

Zhou, J.; Sajid, M. S.; Hormigo, S.; Castro-Alamancos, M. A.

10.1101/2025.05.24.655906 — neuroscience — Posted on 2025-05-24

1381 Advanced neural activity mapping in brain organoids via field potential imaging with ultra-high-density CMOS microelectrodes.

Yokoi, R.; Matsuda, N.; Ishibashi, Y.; Suzuki, I.

10.1101/2025.05.24.655914 — neuroscience — Posted on 2025-05-25

1382 Bimodal peptide collision cross section distribution reflects two stable conformations in the gas phase

Restrepo, J.; Szoelloesi, D.; Kiermeyer, T.; Wichmann, C.; Grubmueller, H.; Cox, J.

10.1101/2025.05.19.654929 — bioinformatics — Posted on 2025-05-24

1383 Sequence alignment with k-bounded matching statistics

Mäklin, T.; Alanko, J. N.; Biagi, E.; Puglisi, S. J.

10.1101/2025.05.19.654936 — bioinformatics — Posted on 2025-05-24

1384 The size of the functional base of support decreases with age

Sloot, L. H.; Gerhardy, T.; Mombaur, K.; Millard, M.

10.1101/2025.05.19.654897 — bioengineering — Posted on 2025-05-24

1385 RAD51AP1 is a versatile RAD51 modulator

Kuhlen, L.; Argunhan, B.; Liang, P.; Zhong, J.; Masino, L.; Zhang, X.

10.1101/2025.05.24.655746 — biochemistry — Posted on 2025-05-24

1386 A Proteolytic Switch: USP5 controls SDE2 function via UBL-directed cleavage

Hales, L. T.; Tammiste, P. M.; Walker, A. J.; Bryce, R.; Sugden, A.; Knebel, A.; Toth, R.; Lamoliatte, F.; Peteri, M.; Curry, O.; De Cesare, V.; Maniaci, C.

10.1101/2025.05.23.655772 — biochemistry — Posted on 2025-05-24

1387 Mitochondrial protein FgDML1 regulates DON toxin biosynthesis and cyazofamid sensitivity in Fusarium graminearum by affecting mitochondrial homeostasis

Wang, C.; Mao, X.; Cong, W.; Yang, L.; Hou, Y.

10.1101/2025.05.23.655648 — microbiology — Posted on 2025-05-24

1388 Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection

Carbone, C. B.; Brown, M.; Balanca, C.; Antonelli, A. C.; Luoh, S.-M.; Banta, K. L.; Rouilly, V.; Pechuan-Jorge, X.; Ortiz-Munoz, G.; Cheung, J.; Marin, I.; Duong, E.; Anand, A.; Chan, C. K.; Rajagopalan, A.; Gibson, J. T.; Lorentzian, A.; Penna, E.; Jiang, J.; Rangell, L.; Liang, Y.; Decalf, J.; Barreira da Silva, R.; Zhu, Y.; Turley, S. J.; Strasser, G. A.; Sanjabi, S.; Geiger-Schuller, K.; Delamarre, L.; Mellman, I.; Moussion, C.

10.1101/2025.05.19.654765 — immunology — Posted on 2025-05-24

1389 Phosphorylation enables allosteric control of a viral condensate

Acker, J.; Wang, X.; Desiro, D.; Agarwal, T.; Colyer, A.; Haller, C.; Scrutton, R.; Sherry, L.; Saar, K. L.; Murray, R.; Fominykh, K.; Chong, S. H.; Schmit, J. D.; Calabrese, A. N.; Knowles, T. N.; Borodavka, A.

10.1101/2025.05.24.655949 — biophysics — Posted on 2025-05-24

1390 SKiD: A Structure-Oriented Kinetics Database of Enzyme-Substrate Interactions

Krishnan, S. R.; Pandey, N.; Srinivasan, R.; Roy, A.

10.1101/2025.05.18.654770 — bioinformatics — Posted on 2025-05-24

1391 Comparative Analysis of Deep Learning Models for Predicting Causative Regulatory Variants

Manzo, G.; Borkowski, K.; Ovcharenko, I.

10.1101/2025.05.19.654920 — bioinformatics — Posted on 2025-05-24

1392 Human genetic variation shapes the antibody repertoire across B cell development

Rodriguez, O. L.; Qiu, X.; Shields, K.; Dunn, C.; Singh, A.; Kaileh, M.; Watson, C. T.; Sen, R.

10.1101/2025.05.19.654982 — genomics — Posted on 2025-05-24

1393 High-throughput linear amplification for single-cell template strand sequencing with sci-L3-Strand-seq

Chovanec, P.; Ridgley, T.; Yin, Y.

10.1101/2025.05.19.654945 — genomics — Posted on 2025-05-24

1394 Mutations in specific MT5-MMP domains prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in cell models of Alzheimer's disease

Belio-Mairal, P.; Kamitsou, A.; Stephan, D.; Jullien, N.; Thiane, D.; Ramos, M.; Louis, L.; Benoist, F.; Serrano, B.; David, M.; Khrestchatisky, M.; Lecorche, P.; Nivet, E.; Rivera, S.

10.1101/2025.05.22.655451 — cell biology — Posted on 2025-05-24

1395 The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control

Yigit, M.; Weber, R.; Ghoshdastider, U.; Das, A.; Nesanir, K.; Valdivia-Francia, F.; Hyams, K.; Taborsky, D.; Renz, P. F.; Ormiston, M.; Dure, C.; Yamahachi, H.; Jovanovic, M.; Sendoel, A.

10.1101/2025.05.22.655611 — molecular biology — Posted on 2025-05-24

1396 Adaptive Machine Learning Framework enables Unprecedented Yield and Purity of Adeno-Associated Viral Vectors for Gene Therapy

Idanwekhai, K.; Shastry, S.; Minzoni, A.; Hurst, M.; Barbieri, E.; Muratov, E.; Daniele, M.; Menegatti, S.; Tropsha, A.

10.1101/2025.05.23.655859 — molecular biology — Posted on 2025-05-24

1397 Identification and characterization of a non-peptidic cyclophilin ligand with antiviral activity against feline and porcine α-coronaviruses.

Delaplace, M.; Khan, M.; Huet, H.; Softic, L.; Ahnou, N.; Bigault, L.; Guichou, J.-F.; Ahmed-Belkacem, A.; Nevers, Q.; Le Poder, S.

10.1101/2025.05.24.655938 — microbiology — Posted on 2025-05-24

1398 A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency

Burgos, S. D.; Ward, A. M.; Ashokkumar, M.; Enders, K. P.; James, L. I.; Margolis, D. M.; Browne, E. P.

10.1101/2025.05.24.655900 — microbiology — Posted on 2025-05-24

1399 Adult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual Memory

Sakelaris, B.; Riecke, H.

10.1101/2024.03.03.583153 — neuroscience — Posted on 2025-05-24

1400 Selectivity filter mutation in NaV1.5 promotes ventricular tachycardia

Selimi, Z.; Tarasov, M.; Meng, X.; Dias, P.; Moise, B.; Veeraraghavan, R.; Radwanski, P.

10.1101/2025.05.19.654350 — physiology — Posted on 2025-05-24

1401 Isoform-Specific Gene Regulation by Progesterone Receptors Drives Divergent Phenotypes in Breast Cancer Cells

Gillis, N. E.; Truong, T. H.; Diep, C. H.; Spartz, A.; Ostrander, J. H.; Lange, C. A.

10.1101/2025.05.19.654935 — cancer biology — Posted on 2025-05-24

1402 Kinetic mechanisms for the sequence dependence of transcriptional errors

Midha, T.; Kolomeisky, A. B.; Igoshin, O. A.

10.1101/2025.03.04.641307 — biophysics — Posted on 2025-05-24

1403 RL-Finetuning of OpenAI o1-mini to Enhance Biomedical Reasoning

Swanson, K.; Chen, Y. T.; Jaech, A.; Zou, J.

10.1101/2025.05.19.654988 — bioinformatics — Posted on 2025-05-24

1404 sandwrm: an R package for estimating Wright's neighborhood size and species-level genetic diversity

Hancock, Z. B.; Bradburd, G.

10.1101/2025.05.19.654925 — bioinformatics — Posted on 2025-05-24

1405 Cross-Species Prediction of Histone Modifications in Plants via Deep Learning

Lv, T.; Han, Q.; Li, Y.; Liang, C.; Ruan, Z.; Chao, H.; Chen, M.; Chen, D.

10.1101/2025.05.19.655006 — bioinformatics — Posted on 2025-05-24

1406 Accurate prediction of protein stability changes from single mutations using self-distillation and antisymmetric constraint strategies

Wang, W.; Zhou, Y.; Huang, X.; Wu, Y.; Li, M.; Zhang, Y.

10.1101/2025.05.18.654422 — bioinformatics — Posted on 2025-05-24

1407 Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes

Suarez-Arnedo, A.; Caston, E. L.; Liu, Y.; Baia, H.; Muddiman, D.; Segura, T.

10.1101/2025.05.19.654672 — bioengineering — Posted on 2025-05-24

1408 ARID1A regulates histone octamer transfer activity of human canonical BAF complex

Moro, N.; Fujisawa-Tanaka, Y.; Watanabe, S.

10.1101/2025.05.21.655315 — biochemistry — Posted on 2025-05-24

1409 Interaction of yeast V-ATPase with TLDc protein Rtc5p

Khan, M. M.; Ebrahimi, R.; Oot, R. A.; Wilkens, S.

10.1101/2025.05.24.655954 — biochemistry — Posted on 2025-05-24

1410 PURE: Policy-guided Unbiased REpresentations for structure-constrained molecular generation

Gupta, A.; Lenin, B.; Current, S.; Batra, R.; Ravindran, B.; Raman, K.; Parthasarathy, S.

10.1101/2025.05.21.655002 — biochemistry — Posted on 2025-05-24

1411 Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies

Elz, A. E.; Gratz, D.; Long, A.; Sowerby, D.; Hadadianpour, A.; Newell, E. W.

10.1101/2025.05.19.654974 — genomics — Posted on 2025-05-24

1412 Assessment of dispersion metrics for estimating single-cell transcriptional variability

Chen, T. T.; Boyer, L. A.; Agarwal, D.

10.1101/2025.05.19.654854 — genomics — Posted on 2025-05-24

1413 Genome Report: Genome of the Amazon Guppy (Poecilia bifurca) reveals conservation of sex chromosomes and dosage compensation

Fong, L. J.; Johnson, B. D.; Darolti, I.; Sandkam, B. A.; Mank, J. E.

10.1101/2025.05.19.654947 — genomics — Posted on 2025-05-24

1414 Optimizing Soybean Breeding: High-Throughput Phenotyping Technologies for Stink Bug Resistance and High Yields

de Oliveira, M.; Aono, A. H.; Braga, P.; Abreu Moreira, A.; Smaniotto Campion, F.; Krause, F. A.; Iost Filho, F. H.; de Bastos Pazini, J.; Takao Yamamoto, P.; Pinheiro, J. B.

10.1101/2025.05.19.654360 — genetics — Posted on 2025-05-24

1415 Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza hemagglutinin

Yu, T. C.; Kikawa, C.; Dadonaite, B.; Loes, A. N.; Englund, J. A.; Bloom, J. D.

10.1101/2025.05.24.655919 — evolutionary biology — Posted on 2025-05-24

1416 Characterisation of Ornithobacterium hominis colonisation dynamics and interaction with the nasopharyngeal microbiome in a South African birth cohort.

De Allende, C. C.; Salter, S. J.; Brigg, S. E.; Claassen-Weitz, S.; Mwaikono, K. S.; Workman, L.; Zar, H. J.; Nicol, M. P.; Parkhill, J.; Dube, F. S.

10.1101/2025.05.24.655922 — microbiology — Posted on 2025-05-24

1417 Life-Stage Transitions Drive Distinct Gut Viral Communities in Dairy Cattle

Cook, R.; Blanchard, A. M.; Marsh, C.; Ponsero, A. J.; Reynolds, J.; Adriaenssens, E. M.; Hudson, C.; Hobman, J.; Stekel, D. J.; Jones, M. A.; Millard, A. D.

10.1101/2025.05.24.655612 — microbiology — Posted on 2025-05-24

1418 Dynamics of cell death due to N and P starvation across intra-clade diversity in Prochlorococcus

Soussan, Y.; Givati, S.; Weissberg, O.; VK, W. B.; Aharonovich, D.; Sher, D. J.

10.1101/2025.05.24.655613 — microbiology — Posted on 2025-05-24

1419 Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

Medina-Serpas, M. A.; Brusko, M.; Golden, G. J.; Campbell-Thompson, M.; Rogers, T.; Posgai, A. L.; Luning-Prak, E. T.; Kaestner, K. H.; Betts, M. R.; McIntyre, L. M.; Atkinson, M. A.; Brusko, T. M.

10.1101/2025.05.19.654940 — immunology — Posted on 2025-05-24

1420 Within-host viral evolution varies with T cell receptor repertoire diversity independently of viral mutation rates

Jamaleddine, H.; Khadra, A.; Mandl, J. N.

10.1101/2025.05.19.654678 — immunology — Posted on 2025-05-24

1421 Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses.

Chang, L. A.; Yeung, S. T.; Warang, P.; Noureddine, M.; Singh, G.; Webb, B. T.; Schotsaert, M.

10.1101/2025.05.19.654943 — immunology — Posted on 2025-05-24

1422 Improved BOLD Detection with Sliced Inverse Regression

Lizarraga, A.; Li, K.

10.1101/2024.02.21.581434 — neuroscience — Posted on 2025-05-24

1423 The interaction between dynamic ligand signaling andepigenetics in Notch-induced cancer metastasis

Chen, T.; Ali-Al-Radhawi, M.; Levine, H.; Sontag, E.

10.1101/2025.05.19.654987 — systems biology — Posted on 2025-05-24

1424 TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques

Tardajos-Ayllon, B.; Diagbouga, M. R.; Edsfeldt, A.; Kalucka, J.; Serbanovic-Canic, J.; Chambers, E.; Sun, J.; Gialeli, C.; Dunning, M.; Li, X.; Xu, S.; Francis, S. E.; Mammoto, A.; Simons, M.; Jorgensen, H. F.; Goncalves, I.; Evans, P. C.

10.1101/2025.05.19.654847 — pathology — Posted on 2025-05-24

1425 AlphaFold3 for Non-canonical Cyclic Peptide Modeling: Hierarchical Benchmarking Reveals Accuracy and Practical Guidelines

Zhang, C.; Wang, W.; Zhu, N.; Cao, Z.; Mao, Q.; Zhu, C.; Zhang, C.; Guo, J.; Duan, H.

10.1101/2025.05.24.655528 — bioinformatics — Posted on 2025-05-24

1426 Employing neutron-encoded monoUbs to study E2/E3 ligase activity and selectivity for assembling Ub chains

van Tol, B. D. M.; van Doodewaerd, B. R.; Lageveen-Kammeijer, G. S. M.; Jansen, B. C.; Liwocha, J.; Mukhopadhyay, R.; Wuhrer, M.; van der Heden-van Noort, G. J.; Schulman, B. A.; Geurink, P. P.

10.1101/2025.05.22.655449 — biochemistry — Posted on 2025-05-24

1427 Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity

zhang, h.; li, x.; he, Q.; LIU, Y.; LIU, B.; LIU, Z.; CHEN, H.; ZHANG, S.; HAN, J.; LIU, Y.; YANG, J.; YIN, H.; GUO, Z.; WEI, Y.; YUAN, Z.; ZHU, H.

10.1101/2025.05.23.655875 — biochemistry — Posted on 2025-05-24

1428 A Tandem Repeat Atlas for the Genome of Inbred Mouse Strains: A Genetic Variation Resource

Ren, W.; Liu, W.; Fang, Z.; Dolzhenko, E.; Weisburd, B.; Cheng, Z.; Peltz, G.

10.1101/2025.05.23.655792 — genetics — Posted on 2025-05-24

1429 The MUC19 Gene: An Evolutionary History of Recurrent Introgression and Natural Selection

Villanea, F. A.; Peede, D.; Kaufman, E. J.; Anorve-Garibay, V.; Chevy, E. T.; Dillon, K. E. W.; Zeloni, R.; Marnetto, d.; Moorjani, P.; Jay, F.; Valdmanis, P. N.; Avila-Arcos, M. C.; Huerta-Sanchez, E.

10.1101/2023.09.25.559202 — evolutionary biology — Posted on 2025-05-24

1430 The SIR2/3/4 complex promotes efficient break-induced replication by stabilizing recombination intermediates

Mackenroth, B.; Alani, E.

10.1101/2025.05.22.655457 — molecular biology — Posted on 2025-05-24

1431 Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

Agarwal, N.; Gogoi, H.; Eeba, E.; Augustin, L.; Khan, M. Y.; Kumar, Y.; Bhowmick, S. K.; Dey, B.

10.1101/2025.04.14.648691 — microbiology — Posted on 2025-05-24

1432 Heterogeneity of functional cellular properties for neurons in mouse cerebral cortex

Ballbe, J.; Calice, M.; Gajowa, M.; Graham, L.

10.1101/2025.03.25.645203 — neuroscience — Posted on 2025-05-24

1433 Neural Maturation Stabilizes Representations and Supports Understanding of Complex Concepts

Watanabe, H.

10.1101/2024.09.22.614315 — neuroscience — Posted on 2025-05-24

1434 Bridging verbal coordination and neural dynamics

Schwab-Mohamed, I.; Mercier, M. R.; Trebuchon, A.; Morillon, B.; Lancia, L.; Schon, D.

10.1101/2024.04.23.590817 — neuroscience — Posted on 2025-05-24

1435 Combined MEG and EEG suggest a limbic source network of the P3 including retrosplenial cortex and hippocampus

Das, D.; Hamalainen, M. S.; Dykstra, A. R.; Rupp, A.; Gutschalk, A.

10.1101/2025.03.24.645008 — neuroscience — Posted on 2025-05-24

1436 A trace-based analysis pipeline for coherent and optimized electrophysiological data analysis

Ballbe, J.; Calice, M.; Gajowa, M.; Graham, L. J.

10.1101/2025.03.25.645208 — neuroscience — Posted on 2025-05-24

1437 Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry

Boatman, A. K.; Kudzin, G. P.; Rock, K. D.; Guillette, M. P.; Robb, F.; Belcher, S. M.; Baker, E.

10.1101/2025.03.20.644452 — pharmacology and toxicology — Posted on 2025-05-24

1438 A multiscale theory for mesenchymal cell migration in straight or curved channel confinement

Shu, W.; Kaplan, C. N.

10.1101/2025.02.26.640464 — biophysics — Posted on 2025-05-24

1439 A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns

Wissing, C.; Eschholz, L. S.; Maheu, M.; Sauter, K.; Morellini, F.; Wiegert, J. S.; Dieter, A.

10.1101/2022.01.22.477348 — neuroscience — Posted on 2025-05-24

1440 Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Sibih, Y. E.; Dada, A. O.; Cunningham, E. E.; Olshausen, N.; Kaur, J.; Jayabal, V.; Oten, S.; Herr, S.; Gonzales, C. N.; Daniel, A.; Krishna, S.; Ambati, V. S.; Aabedi, A. A.; Umbach, G.; Mirchia, K.; Lalwani, P.; Chang, E. F.; Raleigh, D. R.; Nagarajan, S.; Brang, D.; Hervey-Jumper, S. L.

10.1101/2025.05.23.655626 — cancer biology — Posted on 2025-05-24

1441 Development of Paclitaxel Resistance in Triple-Negative Breast Cancer Is Associated with Extensive DNA Methylation Changes That Are Partially Reversed by Decitabine

Trnkova, L.; Burikova, M.; Soltysova, A.; Ficek, A.; Plava, J.; Cumova, A.; Rojikova, L.; Jakic, K.; Sedlackova, E.; Tichy, B.; Bystry, V.; Busato, F.; Shen, Y.; Matuskova, M.; Kucerova, L.; Tost, J.; Miklikova, S.; Cihova, M.; Buocikova, V.; Smolkova, B.

10.1101/2025.05.22.655519 — cancer biology — Posted on 2025-05-24

1442 Circulating Biomarkers for Therapeutic Response to Immune Checkpoint Inhibitor Therapy in Patients with Advanced Lung Cancer

Jain, K.; Mehra, D.; Yadav, M.; Aggarwal, S.; Chugh, P.; tripathi, G.; Ganguly, S.; Rana, R.; Awasthi, A.; Ganguly, N. K.; Maras, J. S.

10.1101/2025.05.21.655239 — cancer biology — Posted on 2025-05-24

1443 In vivo anti-tumor activity of high-dose parenteral ascorbic acid is mediated primarily via cofactor activity, not via oxidative stress.

Akram, T.; Luchtel, R. A.; Dubey, V.; Seal, S.; Aggarwal, R.; Sai, H.; Shenoy, N. K.

10.1101/2025.05.21.655101 — cancer biology — Posted on 2025-05-24

1444 Deficiencies in the Fanconi Anemia or the Homologous Recombination Pathway enhance the antitumor effects of the novel hypoxia-activated prodrug CP-506

Schuitmaker, L.; van der Wiel, A. M. A.; Lieuwes, N. G.; Biemans, R.; Mutsters, N. A. M.; Jung, J.; Claudino Bastos, V.; Prades Sagarra, E.; Kuang, S.; Langie, S. A. S.; Setton, J.; Theys, J.; Yaromina, A.; Dubois, L. J.; Lambin, P.

10.1101/2025.05.21.655302 — cancer biology — Posted on 2025-05-24

1445 Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer

Laforets, F.; Kotantaki, P.; Elorbany, S.; Hartlebury, J.; Joy, J. D.; Malacrida, B.; Bryan-Ravenscroft, R. C.; Berlato, C.; Di Federico, E.; Marshall, J. F.; Manchanda, R.; Jarolimek, W.; Perryman, L.; Maniati, E.; Balkwill, F. R.

10.1101/2025.05.19.654864 — cancer biology — Posted on 2025-05-24

1446 SMARCA4 is essential for early-stage tumor development but its loss promotes late-stage cancer progression in small-cell lung cancer

PARK, K.-S.; Kirk, N. A.; Ly, K.-L.; Ban, Y. H.; Dzhivhuho, G. A.; Ng, J.; Sutherland, K.; Thomas, A.; Kareta, M. S.; Karnezis, A. N.; Park, J.-I.; Jang, J.; Ko, K.-P.

10.1101/2025.05.21.655382 — cancer biology — Posted on 2025-05-24

1447 In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients

Jermakowicz, A.; Ruiz, L.; Chu, J.; Jange, N.; Suter, R. K.; Kadan-Lottick, N.; Hanson, D.; Ayad, N. G.

10.1101/2025.05.23.655845 — cancer biology — Posted on 2025-05-24

1448 PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes

Risner, A.; Nair-Menon, J.; Cheedipudi, A.; Delaney, J. R.; Gangaraju, V.; Kourtidis, A.

10.1101/2025.05.20.655197 — cancer biology — Posted on 2025-05-24

1449 Single-Cell Analysis of Meningiomas Reveals Mutation-Associated Tumor and Immune Cell Gene Expression Programs

Maldonado, J. A.; Mashimo, B. L.; Wang, A. Z.; Desai, R.; Khan, S. M.; Sherpa, N. D.; Anzaldua-Campos, M. I.; Zipfel, G. J.; Kim, A. H.; Dowling, J. L.; Leuthardt, E. C.; Osbun, J. W.; Vellimana, A. K.; Chicoine, M. R.; Dunn, G. P.; Petti, A. A.

10.1101/2025.05.21.655421 — cancer biology — Posted on 2025-05-24

1450 Determining preclinical safety of Aclarubicin in pediatric malignancies

Tu, D. S.; Olson, A. K.; Waggie, K. S.; Garcia, N. M.; Hoglund, V. J.; Walter, S.; Rosinski, J. R.; Sadeeshkumar, H.; Patel, R.; Sayar, E.; Haffner, M.; Maves, L.; Neefjes, J.; Sarthy, J. F.; Lawlor, E. R.; Ganapathi, S. S.

10.1101/2025.05.20.654130 — cancer biology — Posted on 2025-05-24

1451 Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy

Goliwas, K.; Hough, K. P.; Sivan, S.; Single, S. L.; Deshmukh, S. S.; Berry, J. L.; Khalil, M.; Wei, B.; Boumber, Y.; Athar, M.; Desai, A.; Ponnazhagan, S.; Donahue, J. M.; Deshane, J. S.

10.1101/2025.05.19.654890 — cancer biology — Posted on 2025-05-24

1452 Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2

Althoff, M. J.; Minhajuddin, M.; Stevens, B.; Gillen, A. E.; Gipson, S.; Patel, S. B.; Shelton, I. T.; Miller, R.; Vujovic, A.; Krug, A.; Young, T.; Showers, W. M.; Dzieciatkowska, M.; Stephenson, D.; Tyagi, A.; Ellegast, J. M.; Wright, T.; Stegmaier, K.; Opferman, J. T.; D'Alessandro, A.; Smith, C. A.; Jordan, C. T.

10.1101/2025.05.22.655396 — cancer biology — Posted on 2025-05-24

1453 The 1p/19q co-deletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas

Udutha, S.; Batsios, G.; Taglang, C.; Gillespie, A. M.; Viswanath, P.

10.1101/2025.05.20.655097 — cancer biology — Posted on 2025-05-24

1454 Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data

Ustjanzew, A.; Marini, F.; Wagner, S.; Wingerter, A.; Sandhoff, R.; Faber, J.; Paret, C.

10.1101/2025.05.21.655303 — cancer biology — Posted on 2025-05-24

1455 The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

Durand, S.; Boivin, F.; Pommier, R.; Barbollat-Boutrand, L.; Grimont, M.; Pham, F.; Dufeu, M.; Cumunel, E.; Schneider, R.; Ferrari, A.; Eberhardt, A.; Dalle, S.; CARAMEL, J.

10.1101/2025.05.20.654822 — cancer biology — Posted on 2025-05-24

1456 Optimisation of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations

Hawi, G.; Kim, P. S.; Lee, P. P.

10.1101/2025.05.23.655752 — cancer biology — Posted on 2025-05-24

1457 Integrative Multi-Omics Analysis Identifies Nuclear Factor I as a Key Driver of Dysregulated Purine Metabolism in DIPG

Mersich, I.; Congrove, S.; Horchar, M.; Caceres, R.; Muraleedharan, R.; Desai, J.; Desai, P.; Sallans, L.; Reisz, J. R.; Grier, A.; Hass, M.; Donmez, O.; Yin, C.; Weirauch, M. T.; Kottyan, L. T.; Stevenson, C.; Sun, C.; deBlank, P.; Pillay-Smiley, N.; Hummel, T.; Elumalai, N.; Tavassoli, A.; Firestein, R.; Phoenix, T.; D'Alessandro, A.; Dasgupta, B.

10.1101/2025.05.21.655327 — cancer biology — Posted on 2025-05-24

1458 PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer

Rao, X.; Allison, D. B.; Flight, R. M.; Lin, P.; He, D.; Li, Z.; Zhang, Y.; Wang, R.; Li, C.; Wang, J.; Wang, X.; Peng, J.; Fong, K.-W.; Shao, Q.; Wang, C.; Ali, E. S.; Moseley, H. N.; Liu, X.

10.1101/2025.05.21.655274 — cancer biology — Posted on 2025-05-24

1459 Site-Specific Immune and Stromal Architecture Drive Resistance to Trastuzumab Deruxtecan in HER2+ Metastatic Breast Cancer

Das, G.; Vasquez, M.; Zhang, J. A.; Yang, W.; Gao, Y.; Li, X.; Zhao, H.; Wong, S. T.

10.1101/2025.05.23.654950 — cancer biology — Posted on 2025-05-24

1460 Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma

Adhikary, P.; Chakrabarti, J.; Wang, J.; Ezuma-Igwe, U.; Sun, X.; Bastian, W. C.; Braissand, N.; Corbett, M. P.; Douglass, E.; Kim, S.; Kanakamedala, R.; Branch, A. G.; Mallick, S.; Resmi, M. P.; Stevens, P.; Padilla-Rodriguez, M.; Sanchez, M.; Beatty, G. L.; Griffin, J.; Nikolinankos, P. G.; Chen, K.; Riall, T.; Ahmad, S. A.; Shroff, R.; Hollande, F.; Sohal, D.; Zavros, Y.

10.1101/2025.05.22.655586 — cancer biology — Posted on 2025-05-24

1461 Contrastive Representation Learning for Single Cell Phenotyping in Whole Slide Imaging of Enrichment-free Liquid Biopsy

Naghdloo, A.; Tessone, D.; Mandya Nagaraju, R.; Zhang, B.; Kang, J.; Li, S.; Oberai, A.; Hicks, J. B.; Kuhn, P.

10.1101/2025.05.21.655334 — cancer biology — Posted on 2025-05-24

1462 Repurposing Romidepsin for Osteosarcoma: Screening FDA-Approved Oncology Drugs with Three-Dimensional Osteosarcoma Spheroids

Seiden, E. E.; Richardson, S.; Everitt, L. A.; Knafler, G. J.; Kinsella, G. P.; Walker, A. L.; Whiteside, V. A.; Buschbach, J. D.; Gandhi, D. A.; Saadatzadeh, M. R.; Wurtz, L. D.; Getty, P. J.; Padgett, S. L.; Gamblin, R. M.; Childress, M. O.; Fulkerson, C. M.; Pollok, K. E.; Collier, C. D.; Greenfield, E. M.

10.1101/2025.05.22.654354 — cancer biology — Posted on 2025-05-24

1463 Feeding induces c-Fos in hepatocytes contributing to hepatocellular carcinoma in obesity

Li, A.; Gilglioni, E. H.; St-Pierre-Wijckmans, W.; Hosseinzadeh, L.; Veyrat-Durebex, C.; Singh, S. P.; Coppari, R.; Bakiri, L.; Gurzov, E. N.

10.1101/2025.05.20.654880 — cancer biology — Posted on 2025-05-24

1464 An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with Glioblastoma cells stemness features and migration.

D'ARRIGO, P.; DUBOIS, M.; SANCHEZ GIL, J.; LASSENCE, C.; BROUWERS, B.; LOMBARD, A.; ROGISTER, B.; NEIRINCKX, V.; LEBRUN, M.; SADZOT-DELVAUX, C.

10.1101/2025.05.21.655102 — cancer biology — Posted on 2025-05-24

1465 A New Class of Precision Therapeutics that Inhibit Prostate Cancer Mediated Bone Destruction

Qiao, F.; Gordon, R.; Pattanayak, A.; Li, W.; Knibbe-Hollinger, J.; O'Neill, K.; Chen, W.; Mukthapuram, P. R.; Natarajan, A.; Bergan, R.

10.1101/2025.05.20.654990 — cancer biology — Posted on 2025-05-24

1466 Primary CD34+ cells of patients with VEXAS syndrome are highly sensitive to targeted treatment with TAK-243 and pevonedistat

Nowak, D.; Demmerle, M.; Klär, A.; Streuer, A.; Riabov, V.; Altrock, E.; Rapp, F.; Belzer, A.-C.; Klink, T.; Hahn, M.; Hofmann, F.; Nowak, V.; Weimer, N.; Obländer, J.; Palme, I.; Göl, M.; Darwich, A.; Steiner, L.; Abba, M.; Metzgeroth, G.; Hofmann, W.-K.; Schmitt, N.

10.1101/2025.05.22.653244 — cancer biology — Posted on 2025-05-24

1467 A First-in-Class Therapy Targeting Transcription-Replication Conflicts Drives Synthetic Lethality in Homologous Recombination Deficient Cancers

Lim, Y. C.; Lai, S. K.; Yang, R. H.; Chua, Y. K.; Patouret, R.; Manoj, V.; Soh, C.; Lebeau, B.; Cham, N.; Meng, W.; Tey, S. K.; Yeap, S. L.; Zhang, S.; Yong, J.; Ali, Z.; Mutwil, M.; Singh, P.; Fullwood, M.; Zhong, L.; Dong, X.; Chiba, S.; Koh, C. G.; Li, H. Y.

10.1101/2025.05.21.655390 — cancer biology — Posted on 2025-05-24

1468 IL-17A potentiates malignant T-cell viability via electron transport chain complex I in cutaneous T-cell lymphoma

Attrish, D.; Dhamija, B.; Mukherjee, D.; Sawant, V.; Marathe, S.; Saul, D.; Basu, M.; Banik, A.; Sharma, N.; Shet, T.; Jain, H.; Kosinsky, R. L.; Sharma, P.; Purwar, R.

10.1101/2025.05.21.655309 — cancer biology — Posted on 2025-05-24

1469 Targeting Semaphorin 7a signaling in preclinical models of estrogen receptor-positive breast cancer

Steinmetz, R. N.; Fairchild, H.; Wessells, V.; Lyons, T. R.

10.1101/2025.05.21.655360 — cancer biology — Posted on 2025-05-24

1470 Ketogenic diet prevents obesity-associated pancreatic cancer independent of weight loss and induces pancreatic metabolic reprogramming

Velez-Bonet, E.; Gumpper-Fedus, K.; Chasser, K.; Hurst, Z.; Hsueh, H.-Y.; Pita-Grisanti, V.; Liette, A.; Vulic, G.; Choueiry, F.; Zhang, H.; Zhu, J.; Knoblaugh, S. E.; Culp, S.; Volek, J. S.; Cruz-Monserrate, Z.

10.1101/2025.05.20.655200 — cancer biology — Posted on 2025-05-24

1471 Proteomic analysis of exosomes from lymphatic affluents reveals their implications in developing premetastatic niche in melanoma.

Suman, S.; Geng, L.; Nevala, W. K.; Zhao, X.; Sung, J.; Jakub, J. W.; Kandasamy, R. K.; McLaughlin, S. A.; Pandey, A.; Markovic, S. N.

10.1101/2025.05.21.655399 — cancer biology — Posted on 2025-05-24

1472 predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs

Hansen, J.; Iyengar, R.; Martinez, P.; Yadaw, A. S.; Xiong, Y.; Racz, R.; Pacanowski, M. A.; Hopkins, L. L.; King, N. M. P.; Abernethy, D.; Sobie, E.

10.1101/2025.05.23.655401 — cancer biology — Posted on 2025-05-24

1473 Inflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20

Roy, B.; Wu, J.-H.; Freedman, N. J.; Shenoy, S. K.

10.1101/2025.05.20.655129 — cancer biology — Posted on 2025-05-24

1474 Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia

Froid, M.; Branciamore, S.; Chen, Z.; Frankhouser, D.; Fu, Y.-H.; Ambriz, J. R.; Nguyen, L. X. T.; Irizarry, J.; Kuo, Y.-H.; O'Meally, D.; Zhang, B.; Marcucci, G.; Rockne, R.; Basanta, D.

10.1101/2025.05.22.655592 — cancer biology — Posted on 2025-05-24

1475 Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer

Li, H.; Younger, N. S.; Malik, B.; Shin, H. J.; Zhang, C.; Niknafs, Y.; Zhao, S.; Wilder-Romans, K.; Pitchiaya, S.; Han, S.; Barnard, T. J.; Lloyd, P.; Zhang, M.; Chesner, L. N.; Calvert, M.; Egusa, E. A.; Zhu, J.; Chou, J.; Das, R.; Kothari, V.; Shenoy, T.; Diolaiti, M. E.; Malik, R.; Prensner, J. R.; Burlingame, A. L.; Ashworth, A.; Chinnaiyan, A. M.; Feng, F.; Li, H.

10.1101/2025.05.21.655369 — cancer biology — Posted on 2025-05-24

1476 Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma

Zhang, Y.; Debaize, L.; Langenbucher, A.; Weekes, J.; Vogiatzi, I.; Miettinen, T. P.; Zhang, M.; Sumpena, E.; Liu, H.; Duquette, S.; Hackett, L.; Zhang, J.; Baghiyan, S.; Redd, R. A.; Aryee, M.; Davids, M. S.; Kim, A. I.; Ryan, C. E.; Weinstock, D. M.; Manalis, S.; Murakami, M. A.

10.1101/2025.05.20.655210 — cancer biology — Posted on 2025-05-24

1477 Cheminformatic identification of small molecules targeting acute myeloid leukemia

Daneman, M. R.; Meika, B.; Tjahjono, E.; Revtovich, A. V.; Stolbov, L. A.; Gilbertson, S. R.; Poroikov, V. V.; Kirienko, N. V.

10.1101/2025.05.20.655224 — cancer biology — Posted on 2025-05-24

1478 DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres

Ragupathi, A.; Abid, H. Z.; Chen, Y.; Zhao, R.; Kosiyatrakul, S. T.; Yetil, D. I.; Neiswander, J.; Feltman, R.; Thomas, S.; Yusupov, B.; Singh, M.; Zheng, L.; Shen, B.; Zhang, H.; Chu, H.-P. C.; Schildkraut, C. L.; Xiao, M.; Zhang, D.

10.1101/2025.05.22.655602 — cancer biology — Posted on 2025-05-24

1479 Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease

Zarkoob, H.; Kam, C.; Koetsier, J.; Jaiganesh, A.; McCarthy, E.; Kelsell, D.; Sheikh, F.; Godsel, L. M.; Green, K. J.

10.1101/2025.05.21.655405 — cell biology — Posted on 2025-05-24

1480 Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices

Tsolias, A.; Mojica, C. A.; Yamani, R.; Khanna, S. D.; Abdullatif, S. A.; Snyder, B. J.; Chang, W.; Guillamon-Vivancos, T.; Goodliffe, J.; Capriglione, A. L.; Palanca, I. L. T.; Martinez, J.; Campbell, J. D.; Luebke, J. I.; Zeldich, E.; Medalla, M.

10.1101/2025.05.23.655820 — neuroscience — Posted on 2025-05-24

1481 A novel Hox gene promoter fuels the evolution of adaptive phenotypic plasticity

Tian, S.; Lee, B.; Banerjee, T. D.; Murugesan, S. N.; Monteiro, A.

10.1101/2025.05.23.655234 — evolutionary biology — Posted on 2025-05-23

1482 Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis

Pakari, K.; Jakab, S.; Sanchez Salvador, E.; Thiel, C.; Wittbrodt, J.; Thumberger, T.

10.1101/2025.05.23.655727 — developmental biology — Posted on 2025-05-23

1483 Lineage recording in monoclonal gastruloids reveals heritable modes of early development

Regalado, S. G.; Qiu, C.; Kottapalli, S.; Martin, B. K.; Chen, W.; Liao, H.; Kim, H.; Li, X.; Lalanne, J.-B.; Hamazaki, N.; Domcke, S.; Choi, J.; Shendure, J.

10.1101/2025.05.23.655664 — developmental biology — Posted on 2025-05-24

1484 PIKI-1, a class II phosphatidylinositol 3-kinase, functions in endocytic trafficking

Reimann, G. R.; Edeen, P. T.; Conquest, S.; Grant, B. D.; Fay, D. S.

10.1101/2025.05.22.655458 — cell biology — Posted on 2025-05-23

1485 Single kinetochores execute an ordered series of molecular events as the Spindle Assembly Checkpoint is silenced

Conway, C. C.; Germanova, T.; Toral-Perez, S.; Coates, C.; Pines, J.; Burroughs, N. J.; McAinsh, A. D.

10.1101/2025.05.23.655733 — cell biology — Posted on 2025-05-23

1486 Age-associated Tissue Organisation Shifts Retinal Pigment Epithelium Actomyosin Plasticity in Phagocytosis

Piskova, T.; Kozyrina, A. N.; Astrauskaite, G.; Elsafi Mabrouk, M. H.; Schepl, S.; Yam, S. L. S.; Ravithas, R.; Wagner, W.; Vassalli, M.; Di Russo, J.

10.1101/2025.05.22.655517 — cell biology — Posted on 2025-05-23

1487 New glucose-abstaining Chlorella algae doubles mammalian cell culture longevity, boosts performance and drops serum needs enabling scaled applications.

Oey, M.; Marx, U.; Schirra, H. J.; Curson, J. E. B.; Amado, M.; Ross, I. L.; Sweet, M. J.; Blaskovich, M.; Parton, R. G.; Hankamer, B.; Lo, H.

10.1101/2025.05.21.655407 — cell biology — Posted on 2025-05-24

1488 ALPHA/BETA HYDROLASE DOMAIN CONTAINING 5 SUPPORTS GLUCOSE-STIMULATED-LIPOLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS

Kim, L.; Liu, S.; Peachee, S.; Richtsmeier, S.; Jun, C.; Gianna, S.; Vikram, A.; Freshly, A.; Imai, Y.

10.1101/2025.05.21.655350 — cell biology — Posted on 2025-05-24

1489 A Multimodal Spatial and Epigenomic Atlas of Human Adult Lung Topography

Duong, T. E.; Diep, D.; Conklin, K. Y.; Bui, I.; Purkerson, J. M.; Boone, E.; Olness, J.; Patel, S.; Peng, B.; Kern, J. C.; Zhao, Z.; Misra, R. S.; Huyck, H. L.; Verheyden, J. M.; Borok, Z.; Zhang, Y.; Scheuermann, R. H.; Zhu, Q.; Deutsch, G.; Hagood, J. S.; Sun, X.; Zhang, K.; Pryhuber, G.

10.1101/2025.05.23.655666 — cell biology — Posted on 2025-05-24

1490 An innovative in vitro model for studying the biology of cardiac fibroblasts originating from the epicardium

Muller-Sanchez, C.; Muniz-Banciella, M. G.; Reina, M.; Soriano, F. X.; Martinez-Estrada, O. M.

10.1101/2025.05.23.655755 — cell biology — Posted on 2025-05-24

1491 Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation

Srivastava, S.; Samaniego-Castruita, D.; Khurana, S.; Shukla, V.; Ben-Sahra, I.; Foltz, D. R.

10.1101/2025.05.21.655426 — cell biology — Posted on 2025-05-24

1492 A phase-based mechanism of attentional selection in the auditory system

Lui, T. K.-Y.; De Combles De Nayves, V.; Cappe, C.; Zoefel, B.

10.1101/2025.05.23.655714 — neuroscience — Posted on 2025-05-23

1493 AMPA receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving

Sanchez, L. L. H.; Tadros, M. G.; Doan, H. H. T.; Chaudhari, S. R.; Vo, S. V.; Li, T. L.; James, P. B.; Na, A. Y.; Cano, F. J.; Szumlinski, K. K.

10.1101/2025.05.21.655393 — neuroscience — Posted on 2025-05-23

1494 The representation of facial emotion expands from sensory to prefrontal cortex with development

Fan, X.; Tripathi, A.; Bijanki, K.

10.1101/2025.05.23.655726 — neuroscience — Posted on 2025-05-23

1495 Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature and cytoarchitecture.

Priovoulos, N.; Bazin, P.-L.; Brouwer, E. J. P.; Mejias, J. F.; de Buck, M. H. S.; Alkemade, A.; van der Zwaag, W.; Caan, M. W. A.

10.1101/2025.05.23.655715 — neuroscience — Posted on 2025-05-23

1496 De Bruijn Graph Partitioning for Scalable and Accurate DNA Storage Processing

De Moor, F.; Boulle, O.; Lavenier, D.

10.1101/2025.05.19.654814 — bioinformatics — Posted on 2025-05-23

1497 Gene Interaction Network Architecture of Human Polygenic Traits Reveals Domain-Specific Connectivity and Evolutionary Pressures

Tamandeh, E.; Bigge, J.; Serohijos, A.; Schumacher, J.; Maj, C.; Dasmeh, P.

10.1101/2025.05.23.655809 — evolutionary biology — Posted on 2025-05-23

1498 Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis

Naikawadi, R. P.; Bazarov, A.; Wax, M.; Boostanpour, K.; Kukreja, J.; Traglia, M.; Agrawal, A.; Thomas, R.; Bhattacharya, M.; Wolters, P.

10.1101/2025.05.22.655638 — cell biology — Posted on 2025-05-23

1499 Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics

Mezzell, A. T.; Perez, A. M.; Zhang, Y.; Vest, K.

10.1101/2025.05.23.655706 — cell biology — Posted on 2025-05-23

1500 Cryo-Correlative Light and X-ray microscopies: Expanding the Intracellular Chemical Map

Karpov, D.; Cuau, L.; Shishkov, R.; Gramaccioni, C.; Dallerba, E.; Schwehr, B.; Hackett, M.; Plush, S.; Massi, M.; Lerouge, F.; Cloetens, P.; Bohic, S.

10.1101/2025.05.23.655741 — cell biology — Posted on 2025-05-23

1501 Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide.

Akgün, S.; Lenz, T.; Zink, A.; Krings, K. S.; Wesselborg, S.; Mendiburo, M. J.; Prigione, A.; Stühler, K.; Stork, B.

10.1101/2025.05.22.655294 — cell biology — Posted on 2025-05-23

1502 Mutations in specific MT5-MMP domains prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in cell models of Alzheimer's disease

Rivera, S.; Belio-Mairal, P.; Kamitsou, A.; Stephan, D.; Jullien, N.; Thiane, D.; Ramos, M.; Louis, L.; Benoist, F.; Serrano, B.; David, M.; KHRESTCHATISKY, M.; Lecorche, P.; Nivet, E.

10.1101/2025.05.22.655451 — cell biology — Posted on 2025-05-23

1503 mtTF1: A Novel Factor Involved in Mitochondrial Gene Expression in Trypanosoma brucei

Berger, B. M.; Manjunatha, H.; Gerber, M.; Ochsenreiter, T.

10.1101/2025.05.22.655275 — cell biology — Posted on 2025-05-23

1504 A Dual Role for DGAT-mediated Lipid Droplet Biogenesis in Ferroptosis Regulation

Kump, A.; Perne, L.; Koren, S.; Jarc Jovicic, E.; Fegus, N.; Pinto Kozmus, C.; Wölk, M.; Brejchova, K.; Fedorova, M.; Kuda, O.; Petan, T.

10.1101/2025.05.21.655263 — cell biology — Posted on 2025-05-23

1505 Senotherapeutic potential against xeroderma pigmentosum

Wang, X.; Nishida, M.; Yoshioka, A.; Chung, C. Y.-L.; Hashimoto, S.; Tanizawa, H.; Ohta, S.; Noma, K.-i.; Fukumoto, T.

10.1101/2025.05.22.655641 — cell biology — Posted on 2025-05-23

1506 RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response

Ballard-Kordeliski, A.; Ziegmann, N.; Schug, W.; Ginsberg, M. H.; Schaefer, A.; Lee, R. H.; Bergmeier, W.

10.1101/2025.05.22.655614 — cell biology — Posted on 2025-05-23

1507 Nonrandom interchromatin trafficking through dynamic multiphase speckle connections

Kim, J.; Gonzalez, G. A. H.; Venkata, N. C.; Han, K. Y.; Belmont, A. S.

10.1101/2025.05.23.655761 — cell biology — Posted on 2025-05-23

1508 The interplay between Caenorhabditis elegans larval development and Orsay virus infection

Melero, I.; Castiglioni, V. G.; Olmo-Uceda, M. J.; Olmedo, M.; Gonzalez, R.; Elena, S. F.

10.1101/2025.05.23.655711 — microbiology — Posted on 2025-05-23

1509 Socio-emotional difficulties observed in alexithymia reflect altered interactions of the semantic and monoaminergic neuromodulatory brain networks

Montolio, M. I.; Visser, M.; Zareba, M. R.

10.1101/2025.05.23.655721 — neuroscience — Posted on 2025-05-23

1510 Multiscale Entropy of Resting-State fMRI Signals Reveals Differences in Brain Complexity in Autism

Xiao, W.; Jones, M.

10.1101/2025.05.22.655518 — neuroscience — Posted on 2025-05-23

1511 Dynamic mechanisms of time-of-day-dependent adaptive immunity and vaccination responses

Weng, X.; Ouyang, Q.; Wang, H.

10.1101/2025.05.19.654803 — systems biology — Posted on 2025-05-23

1512 Scaling law links plant growth variation to grain yield in wheat stands

Golan, G.; Vasseur, F.; Huang, Y.; Tan, K.; Sadras, V.; violle, c.; Schnurbusch, T.

10.1101/2025.05.19.654792 — plant biology — Posted on 2025-05-23

1513 A polyomavirus-positive Merkel cell carcinoma mouse model supports a unified cancer origin

yang, w.; contente, s.; rahman, s.

10.1101/2025.05.06.652325 — cancer biology — Posted on 2025-05-23

1514 PEARL: Integrative multi-omics classification and omics feature discovery via deep graph learning

Zhao, Q.; Du, J.; Zhou, M.; Wang, X.-W.; Sun, Q.; Chen, C.

10.1101/2025.05.19.654754 — bioinformatics — Posted on 2025-05-23

1515 Structural Analysis and Docking Studies of FK506-Binding Protein 1A

Guven, O.; DeMirci, H.

10.1101/2025.05.22.655516 — biochemistry — Posted on 2025-05-23

1516 APOBEC5: characterisation of a novel member of the AID/APOBEC protein family

Tian, S.; Ellenberg, P.; Kouskousis, B.; Tachedjian, G.; Hayward, J. A.

10.1101/2025.05.21.655229 — evolutionary biology — Posted on 2025-05-23

1517 Pyrethroid resistance intensity in Anopheles gambiae s.l. mosquito populations from Rwanda

Lambert, N.; Torbert Yvan, M.; Pascal, M.; Gerald, H.; Alphonse, M.; Aimable, M.; Dunia, M.; Emmanuel, H.

10.1101/2025.05.21.655281 — evolutionary biology — Posted on 2025-05-23

1518 Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

Casas, A.; Imlay, L. S.; Thathy, V.; Fairhurst, K. J.; Lehane, A. M.; Lawong, A. K.; Deni, I.; Striepen, J.; Lee, S.; Kumar, A.; Xing, C.; Niederstrasser, H.; Posner, B. A.; Laleu, B.; Charman, S. A.; Fidock, D. A.; Ready, J. M.; Phillips, M. A.

10.1101/2025.05.20.655166 — microbiology — Posted on 2025-05-23

1519 Hippocampal mechanisms resolve competition in memory and perception

Favila, S. E.; Aly, M.

10.1101/2023.10.09.561548 — neuroscience — Posted on 2025-05-23

1520 Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies

Wagner-Carena, J. A.; Kate, S.; Riordan, T.; Abbasi-Asl, R.; Aman, J.; Amster, A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Buice, M. A.; Bumbarger, D. J.; Collman, F.; da Costa, N. M.; Denman, D. J.; de Vries, S. E.; Joyce, E.; Kapner, D.; King, C. W.; Larkin, J. D.; Lecoq, J.; Mahalingam, G.; Millman, D.; Molter, J.; Morrison, C.; Reid, R. C.; Schneider-Mizell, C. M.; Daniel, S.; Suckow, S.; Takasaki, K. T.; Torres, R.; Vumbaco, D.; Waters, J.; Wyrick, D. G.; Yin, W.; Zhuang, J.; Takeno, M.; Mihalas, S.; Berteau, S.

10.1101/2025.04.24.649900 — neuroscience — Posted on 2025-05-23

1521 Multiscale Probabilistic Modeling: A Bayesian Approach to Augment Mechanistic Models of Cell Signaling with Machine-Learning Predictions of Binding Affinity

Huber, H. A.; Finley, S. D.

10.1101/2025.05.23.655795 — systems biology — Posted on 2025-05-23

1522 Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

Khajuria, P.; Kour, D.; Sharma, K.; Singh, L.; Banoo, R.; Manhas, D.; P, R.; Nandi, U.; Bharate, S.; Ahmed, Z.; Kumar, A.

10.1101/2025.05.19.654834 — pharmacology and toxicology — Posted on 2025-05-23

1523 RareFold: Structure prediction and design of proteins with noncanonical amino acids

Li, Q.; Daumiller, D.; Bryant, P.

10.1101/2025.05.19.654846 — bioinformatics — Posted on 2025-05-23

1524 Prevalence of Group II Introns in Phage Genomes

Merk, L. N.; Jones, T. A.; Eddy, S. R.

10.1101/2025.05.22.655115 — bioinformatics — Posted on 2025-05-23

1525 Learning molecular traits of human pain disease via voltage-gated sodium channel structure renormalization

Xenakis, M.; Lampert, A.

10.1101/2025.02.19.639033 — bioinformatics — Posted on 2025-05-23

1526 TEITbase: a database for transposable element (TE)-initiated transcripts in human cancers

Zhang, Y.; She, J.; Hu, X.; Jin, Y.; Tao, C.; Du, M.; Yang, E.

10.1101/2025.05.19.654796 — bioinformatics — Posted on 2025-05-23

1527 EYKTHYR reveals transcriptional regulators of spatial gene programs

Krieger, S.; Haber, E.; Ma, J.

10.1101/2025.05.19.654884 — bioinformatics — Posted on 2025-05-23

1528 stTrace: Detecting Spatial-Temporal Domains from spatial transcriptome to Trace Developmental Path

Song, Z.; Zheng, C.; Chen, J.

10.1101/2025.05.19.654812 — bioinformatics — Posted on 2025-05-23

1529 A 3D Endothelium-on-a-Chip Model Uncovers Cx43-Dependent Glycolytic Shift and Endothelial Barrier Dysfunction in Diabetic Kidney Disease

Lialios, P.; Kim, Y.; Trewhella, I.; Myakala, K.; Hughes, E.; Wang, X.; Levi, M.; Alimperti, S.

10.1101/2025.05.19.654627 — bioengineering — Posted on 2025-05-23

1530 Decoding protein-peptide interactions using a large, target-agnostic yeast surface display library

Hurley, J.; Shlosman, I.; Lakshminarayan, M.; Zhao, Z.; Yue, H.; Nowak, R.; Fischer, E. S.; Kruse, A.

10.1101/2025.05.19.654863 — bioengineering — Posted on 2025-05-23

1531 Design, Expression, and Purification of a Soluble Form of the Retina-Specific Membrane Transporter, ABCA4

Alturkestani, A. A.; Jones, J. S.; Cevik, S.; Biswas-Fiss, E. E.; Biswas, S. B.

10.1101/2025.05.22.655561 — biochemistry — Posted on 2025-05-23

1532 RNAse-free manufacture of Venezuelan Equine Encephalitis Virus (VEEV) plasmid DNA vaccine

Wilson, T.; Harding, M.; Packninathan, C.; Khan, F.; Zarling, S.; Dutta, S.

10.1101/2025.05.22.655656 — biochemistry — Posted on 2025-05-23

1533 De Novo Hydration of Cryo-EM Reconstructions through Molecular Dynamics Simulations of the Excess Chemical Potential

Sun, Q.; Aiyer, S.; Biswas, A.; Haldane, A.; Chatterjee, S.; Matubayasi, N.; Lyumkis, D.; Levy, R. M.

10.1101/2025.05.23.655847 — biochemistry — Posted on 2025-05-23

1534 Regulation of the essential peptidoglycan hydrolytic complex FtsEX-PcsB during Streptococcus pneumoniae cell division

Briggs, N. S.; Bruce, K. E.; Camaione, S.; Naskar, S.; Lloyd, A. J.; Winkler, M. E.; Roper, D. I.

10.1101/2025.05.23.655736 — biochemistry — Posted on 2025-05-23

1535 Collective unstructured interactions drive chromatin binding of transcription factors

Abidi, A. A.; Dailey, G. M.; Tjian, R.; Graham, T. G. W.

10.1101/2025.05.16.654615 — biochemistry — Posted on 2025-05-23

1536 A method for massively scalable phylogenetic network inference

Kolbow, N.; Kong, S.; Solis-Lemus, C.

10.1101/2025.05.05.652278 — evolutionary biology — Posted on 2025-05-23

1537 Directing conservation action for the Critically Endangered Philippine Eagle to mitigate mining impacts and maximize indigenous land management

Sutton, L. J.; Ibanez, J. C.; Salvador, D. I.; Tirona, A. V. M. C.; Opiso, G. S.; Senarillos, T. L. P.; Suetos, K. J.; Taraya, R. L.; McClure, C. J. W.

10.1101/2025.05.19.654818 — ecology — Posted on 2025-05-23

1538 Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids

McCutcheon, C.; Caldwell, A.; Yang, L.; Crisci, E.; Pasternak, J. A.; Coyne, C.

10.1101/2024.10.21.619461 — developmental biology — Posted on 2025-05-23

1539 Anti-resonance in developmental signaling regulates cell fate decisions

Rosen, S. J.; Witteveen, O.; Baxter, N.; Lach, R. S.; Hopkins, E.; Bauer, M.; Wilson, M. Z.

10.1101/2025.02.04.636331 — cell biology — Posted on 2025-05-23

1540 Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Zhang, C.; Liang, N.; Li, W.; Xu, S.; Li, P.; Ni, W.; Li, N.; Han, S.; Ou, N.; Bai, H.; Zhang, Y.; Bai, F.; Sun, Y.; Qian, D.; Bu, X.; Zhi, E.; Tian, R.; Huang, Y.; Zhao, J.; Zhao, F.; chen, H.; Li, Z.; Yao, C.

10.1101/2025.05.21.654986 — molecular biology — Posted on 2025-05-23

1541 Context-Dependent Regulation of Microhomology-Mediated End Joining in Normal Tissues: Insights into Tissue-Specific Activation of DNA Repair Pathways

Rathore, D.

10.1101/2025.05.23.653089 — molecular biology — Posted on 2025-05-23

1542 Transposable elements create distinct genomic niches for effector evolution among Magnaporthe oryzae lineages

Sampaio, M.; Croll, D.

10.1101/2025.05.23.655716 — microbiology — Posted on 2025-05-23

1543 Commensal to pathogen switch in Streptococcus pneumoniae is governed by a thermosensing master regulator

Apte, S.; Pereira, G.; Ghosh, S.; Mandal, S. K.; Badgujar, L.; Gosavi, K.; Pohler, E.; Blake, A.; PI, P.; Neill, D. R.; Banerjee, A.

10.1101/2025.05.23.655729 — microbiology — Posted on 2025-05-23

1544 The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

Lee, J.; Ouellette, S. P.

10.1101/2024.05.24.595738 — microbiology — Posted on 2025-05-23

1545 Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during Mycobacterium tuberculosis infection

Hazra, R.; Ozturk, M.; Peton, N.; Ganief, T.; Poswayo, S. K.; Rousseau, R. P.; Naidoo, S.; Jones, S.-S.; Savulescu, A. F.; Moseki, R.; Abhimanyu, A.; Plessis, N. D.; Blackburn, J.; Mhlanga, M. M.; Kahn, C. R.; Brombacher, F.; Wilkinson, R. J.; Parihar, S. P.

10.1101/2025.05.19.653976 — immunology — Posted on 2025-05-23

1546 Potent Neutralization by Antibodies Targeting the Mpox A28 Protein

Yefet, R.; Battini, L.; Hubert, M.; Rakayev, K.; GUIVEL-BENHASSINE, F.; Rattner, N.; Porrot, F.; Abramovitz, L.; Ostashinsky, G.; Ben-Shalom, N.; Postal, J.; Polonsky, K.; Ralph-Altman, M.; Sweed, S.; Korner, T.; Friedel, N.; Hagin, D.; Sprecher, E.; Fishelson, Z.; Kobiler, O.; Adler-Abramovich, L.; Schwartz, O.; Guardado-Calvo, P.; Freund, N.

10.1101/2025.05.22.655505 — immunology — Posted on 2025-05-23

1547 The maternal inflammatory proteome during pregnancy and its role in predicting the risk of spontaneous preterm birth

Laleye, F.; Jackson, R.; Mi, J. D.; Shennan, A. H.; Hezelgrave - Elliott, N.; Vigilante, A.; Camunas-Soler, J.; Rasmussen, M.; Tribe, R. M.

10.1101/2025.05.19.654577 — systems biology — Posted on 2025-05-23

1548 Using domain insertion to create sulfite reductases that present chemical-dependent activities

Windham, E.; Myerscough, D.; Schwartz, S.; Carpenter, M.; Ajo-Franklin, C.; Silberg, J.

10.1101/2025.05.23.655854 — synthetic biology — Posted on 2025-05-23

1549 In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis

Vu, K. P.; Gunti, S.; Viswanathan, R.; Nandal, A.; Larkin, R.; Cho, S.; Zou, J.; Ramolia, S.; Hoke, A. T. K.; Barbosa, S. M.; Gallia, G. L.; Rooper, L. M.; Floudas, C. S.; Cheng, H.; Miller, C. N.; Guest, M. R.; Notaro, M.; Raziuddin, A.; Sun, Z.; Wu, X.; Faraji, F.; Lechner, M.; Comoglio, F.; Edmondson, E. F.; Chari, R.; London, N. R.

10.1101/2025.05.19.654661 — cancer biology — Posted on 2025-05-23

1550 Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein

Johnson, D. H.; Kou, O. H.; White, J. M.; Ramirez, S. Y.; Margaritakis, A.; Chung, P. J.; Jaeger, V. W.; Zeno, W. F.

10.1101/2024.11.14.623669 — biophysics — Posted on 2025-05-23

1551 D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response

Jiang, J.; Chen, S.; Tsou, T.; McGinnis, C. S.; Khazaei, T.; Zhu, Q.; Park, J. H.; Strazhnik, I.-M.; Vielmetter, J.; Gong, Y.; Hanna, J.; Chow, E. D.; Sivak, D. A.; Gartner, Z. J.; Thomson, M.

10.1101/2023.04.19.537364 — bioinformatics — Posted on 2025-05-23

1552 upsAI: A high-accuracy machine learning classifier for predicting Plasmodium falciparum var gene upstream groups

Pangilinan, E. A.; Quenu, M.; Claessens, A.; Otto, T. D.

10.1101/2025.05.19.654848 — bioinformatics — Posted on 2025-05-23

1553 RBPSignal: A deep learning approach for predicting RNA-Protein binding signals

Ding, X. S.; Shu, Z. A.; Wang, S.; Shi, L.; Zhou, Y.; Zhang, B.; Shen, H.-B.; Liu, X.; Pan, X.

10.1101/2025.05.19.654811 — bioinformatics — Posted on 2025-05-23

1554 Multiscale analysis and optimal glioma therapeutic candidate discovery using the CANDO platform

XU, S.; Mangione, W.; Norden, M. V.; Elefteriou, K.; Hu, Y.; Falls, Z.; Samudrala, R.

10.1101/2025.05.19.654757 — bioinformatics — Posted on 2025-05-23

1555 Bio-sintering of Limestone to Produce Pollution Free Cement

Murugan, R.; Mukherjee, A.; Dubey, A.; Dhami, N.

10.1101/2025.05.19.654766 — bioengineering — Posted on 2025-05-23

1556 A survey of human cancer-germline genes: linking X chromosome localization, DNA methylation and sex-biased expression in early embryos

Loriot, A.; Devis, J.; Gatto, L.; De Smet, C.

10.1101/2025.05.19.654804 — genomics — Posted on 2025-05-23

1557 Sex-biased dispersal drives mito-nuclear discordance in simulated populations

Giannelli, F.; Ferrer Obiol, J.; Trucchi, E.

10.1101/2025.05.19.654820 — genomics — Posted on 2025-05-23

1558 Aeromonas: Genomic Insights into an Environmental Pathogen and Reservoir of Antimicrobial Resistance

Singh, N.; Golicha, R. O.; Thakur, C.; Beale, M. A.; Dorman, M. J.; Cazares, A.; Taylor-Brown, A.; Johura, F.-T.; Rashid, M. u.; Monira, S.; Zohura, F.; Parveen, T.; Bhuiyan, S. I.; Sultana, M.; Mohan, B.; Domman, D.; George, C. M.; Kariuki, S.; Alam, M.; Taneja, N.; Thomson, N. R.

10.1101/2025.05.22.655522 — genomics — Posted on 2025-05-23

1559 Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors

Schippel, N.; Kala, M.; Sharma, S.

10.1101/2024.08.29.610192 — developmental biology — Posted on 2025-05-23

1560 A cell and transcriptome atlas of the human arterial vasculature reveals roles of developmental master regulators in health and disease

Zhao, Q.; Pedroza, A.; Sharma, D.; Gu, W.; Dalal, A.; Weldy, C.; Jackson, W.; Li, D. Y.; Ryan, Y.; Nguyen, T.; Shad, R.; Palmisano, B. T.; Monteiro, J. P.; Worssam, M.; Berezwitz, A.; Iyer, M.; Shi, H.; Kundu, R.; Limbu, L.; Kim, J. B.; Kundaje, A.; Fischbein, M.; Wirka, R.; Quertermous, T.; Cheng, P.

10.1101/2024.09.10.612293 — cell biology — Posted on 2025-05-23

1561 Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR

Takaoka, S.; Jaso-Vera, M. E.; Ruan, X.

10.1101/2025.05.22.655551 — molecular biology — Posted on 2025-05-23

1562 Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

Sakaue, H.; Izumi-Mishima, Y.; Tsutsumi, R.; Shiuchi, T.; Fujimoto, S.; Taniguchi, M.; Sugiuchi, M.; Tsutsumi, M.; Okamatsu-Ogura, Y.; Yoneshiro, T.; Kuroda, M.; Nomura, K.

10.1101/2024.05.26.595945 — molecular biology — Posted on 2025-05-23

1563 Cardiac neurotrophic signaling impairment, amyloid β, and the Alzheimer s disease heart

Elia, A.; Parodi-Rullan, R. M.; Vazquez-Torres, R.; Carey, A.; Javadov, S.; Fossati, S.

10.1101/2023.07.11.548558 — molecular biology — Posted on 2025-05-23

1564 Bacteria detect neutrophils via a system that responds to hypochlorous acid and flow

Foik, I. P.; Shu, R.; Abbondante, S.; Kasallis, S. J.; Urban, L. A.; Huang, A. P.; Duong, L.; Marshall, M. E.; Pearlman, E.; Downing, T. L.; Siryaporn, A.

10.1101/2022.02.01.478687 — microbiology — Posted on 2025-05-23

1565 Highly Pathogenic Avian Influenza A(H5N1) Caused Mass Death among Black-legged Kittiwakes (Rissa tridactyla) in Norway, 2023

Romo, G.; Piercey Akesson, C.; Reiertsen, T. K.; Fosse, J. H.; Arnason Boe, C.; Austbo, L.; Akerstedt, J.; Saghafian, M.; Helberg, M.; Hungnes, O.; Gjerset, B.; Granstad, S.; Hogseth, G.; Lotvedt, S.; Dosen, A.; Tonnessen, R.

10.1101/2025.05.23.655725 — microbiology — Posted on 2025-05-23

1566 Melatonin Enhances Sleep via MT1-Driven Activation of Slo1 in Suprachiasmatic Nucleus Neurons

Wang, Z.-W.; Vedantham, K.; Ahmad, A.; Niu, L.-G.; Shui, Y.; Lemtiri-Chlieh, F.; Kaback, D.; Ma, X.-M.; Yee, S.-P.

10.1101/2025.03.12.642893 — neuroscience — Posted on 2025-05-23

1567 Behavioral and genetic analysis of the effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) in C. elegans

White, A. M.; Bauer, A. D.; Faumont, S.; Lockery, S. R.

10.1101/2025.03.03.641301 — neuroscience — Posted on 2025-05-23

1568 Muscarinic type 1 receptor activated effectors in principal neurons of the rat basolateral amygdala

Sahagian, T. J.; Harden, S. W.; Bizon, J. L.; Setlow, B.; Frazier, C. J.

10.1101/2025.03.14.643393 — neuroscience — Posted on 2025-05-23

1569 Feedback control stabilizing the center of mass can be identified in unperturbed, upright standing

Geng, Y.; Bruijn, S. M.; van Dieën, J. H.

10.1101/2024.12.20.629656 — neuroscience — Posted on 2025-05-23

1570 Orexin population activity precisely reflects net body movement across behavioral and metabolic states

Tesmer, A. L.; Viskaitis, P.; Donegan, D.; Bracey, E.; Grujic, N.; Patriarchi, T.; Peleg-Raibstein, D.; Burdakov, D.

10.1101/2024.08.13.607750 — neuroscience — Posted on 2025-05-23

1571 When good guides go bad: empirical evaluation of all unique Cas9 targets in E. coli reveal widespread functionality and rules for gRNA biological design

Phillips, E. K.; Harrison, R.; Charles, S.; Klingeman, D. M.; Wiser, T.; Eckert, C. A.; Alexander, W. G.

10.1101/2025.05.23.651106 — synthetic biology — Posted on 2025-05-23

1572 Orchestrating Self-Replication in Artificial Cells through Digital Microfluidics

Zhai, G.; Dimitriou, P.; Sengel, J. T.; Wallace, M. I.

10.1101/2025.05.23.655734 — synthetic biology — Posted on 2025-05-23

1573 Dynamic regulation of protein homeostasis underlies acquiredthermotolerance in Arabidopsis thaliana

Bajaj, M.; Allu, A. D.; Rao, B. J.

10.1101/2023.08.04.552042 — plant biology — Posted on 2025-05-23

1574 A Chromosome-scale Reference Genome of Meloidogyne hapla reveals localized recombination hotspots enriched with Effector Proteins

Shakya, P.; Maulana, M. I.; Danchin, E.; Voogt, M. l.; van de Ruitenbeek, S. J. S.; Gimeno, J.; Taranto, A. P.; Blundell, A. C.; Despot-Slade, E.; Mestrovic, N.; Mota, A. Z.; Dai, D.; Williamson, V. M.; Sterken, M. G.; Siddique, S.

10.1101/2025.05.21.654606 — plant biology — Posted on 2025-05-23

1575 RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

Jangde, N.; Lee, M. H.; Ruiz, L.; Egan, I.; Jermakowicz, A.; Wynn, D.; Goka, E.; Lippman, M.; Robbins, D. J.; Ayad, N. G.

10.1101/2025.05.22.655563 — pharmacology and toxicology — Posted on 2025-05-23

1576 Testing for a wildlife reservoir of divergent SARS-CoV-2 in white-tailed deer

Crawshaw, L.; Kotwa, J. D.; Jeeves, S. P.; Loomer, C.; Dibernardo, A.; Stewart, A.; Newar, S. L.; Chien, E.; Yim, W.; Kruczkiewicz, P.; Vernygora, O.; Lung, O.; Schulte-Hostedde, A. I.; Maguire, F.; Pickering, B.; Jardine, C. M.; Coatsworth, H.; Mubareka, S.; Bowman, J.

10.1101/2025.05.22.655348 — pathology — Posted on 2025-05-23

1577 Trikafta rescues F508del-CFTR by tightening specific phosphorylation-dependent interdomain interactions

Wang, G.

10.1101/2024.11.20.624197 — biophysics — Posted on 2025-05-23

1578 Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds

Alonso Matilla, R.; Pedro, D. I.; Pepe, A.; Serrano-Velez, J.; Dunne, M.; Nguyen, D. T.; Sawyer, W. G.; Provenzano, P. P.; Odde, D. J.

10.1101/2023.10.29.564655 — biophysics — Posted on 2025-05-23

1579 The membrane transition strongly enhances biopolymer condensation through prewetting

Bagheri, Y.; Rouches, M.; Machta, B.; Veatch, S. L.

10.1101/2024.08.26.609758 — biophysics — Posted on 2025-05-23

1580 Triad-LMF: A Hierarchical Low-Rank Multimodal Fusion Framework for Robust Cancer Subtype Classification Using Multi-Omics Data

Tan, X.; Chen, X.; Tian, R.; Yang, D.; Jiang, M.; Zhang, L.

10.1101/2025.05.15.653805 — bioinformatics — Posted on 2025-05-23

1581 A Gm6AG-binding protein from Vibrio cholerae.

cao, y.; xu, j.; lu, x.; huang, f.; chen, w.; wang, x.; zhu, b.

10.1101/2025.05.22.655678 — biochemistry — Posted on 2025-05-23

1582 Draft genome and transcriptomic sequence data of three invasive insect species

Lombaert, E.; Klopp, C.; Blin, A.; Annonay, G.; Iampietro, C.; Lluch, J.; Sallaberry, M.; Valiere, S.; Poloni, R.; Joron, M.; Deleury, E.

10.1101/2024.12.02.626401 — genomics — Posted on 2025-05-23

1583 Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit

Sanders, E. N.; Sun, H.-T.; Tabatabaee, S.; Lang, C. F.; van Dijk, S. G.; Su, Y.-H.; Labott, A.; Idris, J.; He, L.; Marchetti, M.; Xie, S.; O'Brien, L. E.

10.1101/2024.12.29.630675 — developmental biology — Posted on 2025-05-23

1584 Intrinsic Heterogeneity of Primary Cilia Revealed Through Spatial Proteomics

Hansen, J. N.; Sun, H.; Kahnert, K.; Westenius, E.; Johannesson, A.; Villegas, C.; Le, T.; Tzavlaki, K.; Winsnes, C.; Pohjahnen, E.; Maekiniemi, A.; Fall, J.; Navarro, F. B.; Backstrom, A.; Lindskog, C.; Johansson, F.; von Feilitzen, K.; Vega, A. D.; Casals, A. M.; Mahdessian, D.; Uhlen, M.; Sheu, S.-H.; Lindstrand, A.; Axelsson, U.; Lundberg, E.

10.1101/2024.10.20.619273 — cell biology — Posted on 2025-05-23

1585 The biomolecular profiles of extracellular vesicles from odontogenic stem cell lines depict donor-dependent differences and emphasize their therapeutic and regenerative potential

Xu, Y.; Sarisoy, A.; Buhl, E. M.; Salviano-Silva, A.; Gonzalez Rubio, J.; Thiebes, A. L.; Fuest, S.; Smeets, R.; Ricklefs, F. L.; Apel, C.

10.1101/2025.05.13.653575 — cell biology — Posted on 2025-05-23

1586 The metabolic mechanisms underlying zooplankton derived dissolved organic matter chemical properties

Nuruddin, M. F.; Ding, H.; WU, L.

10.1101/2024.10.27.620474 — molecular biology — Posted on 2025-05-23

1587 Virome profiling of Culex tarsalis through small RNA-seq: A challenge of suboptimal samples

Manzano-Alvarez, J.; Asad, S.; Chaverra-Rodriguez, D.; Suh, E.; Rasgon, J. L.

10.1101/2025.05.23.655811 — microbiology — Posted on 2025-05-23

1588 Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders

Espinoza, D. A.; Zrzavy, T.; Breville, G.; Thebault, S.; Marefi, A.; Mexhitaj, I.; Yamashita, L. D.; Kan, M.; Bacchus, M.; Legaspi, J.; Fernandez, S.; Melamed, A.; Stubblebine, M.; Kim, Y.; Martinez, Z.; Diorio, C.; Schulte-Mecklenbeck, A.; Wiendl, H.; Rezk, A.; Li, R.; Narula, S.; Waldman, A.; Hopkins, S. E.; Banwell, B.; Bar-Or, A.

10.1101/2025.02.27.637541 — immunology — Posted on 2025-05-23

1589 Microstructural and geochemical evidence offers a solution to the cephalopod cameral deposits riddle

Pohle, A.; Hoffmann, R.; Nützel, A.; Seuss, B.; Aubrechtova, M.; Kröger, B.; Stevens, K.; Immenhauser, A.

10.1101/2025.02.25.639475 — paleontology — Posted on 2025-05-23

1590 Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation

Ibikunle, C. O.; Xue, C.; Kim, E.; Yan, H.; Coronel, J.; Zhu, L. Y.; Cui, J.; Chung, A.; Bauer, R. C.; Sachs, N.; Maegdefessel, L.; Li, M.; Tall, A. R.; Bashore, A. C.; Reilly, M.

10.1101/2025.05.20.655228 — molecular biology — Posted on 2025-05-23

1591 Functional Characterization of Zymoseptoria tritici Candidate Effectors Reveals Their Role in Modulating Immunity in Nicotiana benthamiana

Gomez-Gutierrez, S. V.; Rodriguez-Diaz, C.; Jaiswal, N.; Gribskov, M.; Helm, M.; Goodwin, S. B.

10.1101/2025.05.20.655180 — molecular biology — Posted on 2025-05-23

1592 CD200R1 is required for the development of γδ 17 T cells

Linley, H.; Jaigirdar, S.; Buckingham, L.; Cox, J.; Priestley, M.; Hains, A.; Saunders, A.

10.1101/2025.05.19.654867 — immunology — Posted on 2025-05-23

1593 Actionable biological programs to enhance EGFR-targeted therapy response unveiled by single-cell lineage tracing in clinically relevant lung cancer models

Gini, B.; Tamaki, W.; Yu, J. X.; Barbosa, D.; Wu, W.; Pourmoghadam, Y.; Allegakoen, P.; Kim, D.; Miglani, S.; Elmes, S.; Olivas, V.; Goodarzi, H.; Bivona, T. G.

10.1101/2025.05.19.654081 — cancer biology — Posted on 2025-05-23

1594 Polar organization of H&E dyes in histology tissue revealed by polarimetric nonlinear microscopy

Maciulis, M.; Mazeika, V.; Kontenis, L.; Tokarz, D.; Cisek, R.; Bulotiene, D.; Karabanovas, V.; Barzda, V.

10.1101/2025.05.19.654795 — biophysics — Posted on 2025-05-23

1595 Substrate heterogeneity promotes cancer cell dissemination

Dunajova, Z.; Tasciyan, S.; Majek, J.; Merrin, J.; Sahai, E.; Sixt, M.; Hannezo, E.

10.1101/2025.05.20.655037 — biophysics — Posted on 2025-05-23

1596 Exploring Holography in Neuro-Vascular Dynamics

Kerskens, C.

10.1101/2025.05.19.654699 — biophysics — Posted on 2025-05-23

1597 Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.

Mondal, M.; Swetman, W. S.; Karim, S. U.; Shrestha, S.; Davis, A. M.; Bai, F.; Huang, F.; Clemons, T. D.; Rangachari, V.

10.1101/2025.05.20.655132 — biophysics — Posted on 2025-05-23

1598 Development of visible light-sensitive human OPN5 via single amino acid substitution

Sakai, Y.; McDowell, R. J.; Lucas, R. J.

10.1101/2025.05.19.654910 — biophysics — Posted on 2025-05-23

1599 Free Energy Landscape of Magnesium Chelation Reveals Dynamic Pre-Chelate Complexes Stabilized by Meta-Sphere RNA-Ion Coordination

ROY, S.; JAISWAR, A.; SARKAR, R.; MAINAN, A.; KUNDU, R.

10.1101/2025.05.20.655240 — biophysics — Posted on 2025-05-23

1600 Differential conformational expansion of Nup98-HOXA9 oncoprotein in micro- and macrophases

Lemke, E. A.; Girard, M.; Ruan, H.; Dillenburg, R.; Wittmann, S.

10.1101/2025.05.21.655138 — biophysics — Posted on 2025-05-23

1601 ChipNMR: Hyperpolarized NMR for non-invasive metabolic flux analysis in perfused microfluidic chips

Wareham Mathiassen, T. B.; Karlsson, M.; Sanchez-Heredia, J. D.; Wang, K.-C.; Haupt, C. R.; Jonsson, A.; Dufva, M.; Thuenauer, R.; Rose Jensen, P.

10.1101/2025.05.20.654798 — biochemistry — Posted on 2025-05-23

1602 The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair

Kim, M.; Jeong, E.; Park, J.; Tsai, M.-S.; Yan, C.; Ivanov, I.; Kim, H. S.; Scharer, O. D.

10.1101/2025.05.20.655039 — biochemistry — Posted on 2025-05-23

1603 Tuning Encodable Tetrazine Chemistry for Site-Specific Protein Bioorthogonal Ligations

Jana, S.; Eddins, A. J.; Gangarde, Y. M.; Karplus, P. A.; Mehl, R. A.

10.1101/2025.05.20.655094 — biochemistry — Posted on 2025-05-23

1604 Dissociation of the mTOR protein interaction network following neuronal activation is altered by Shank3 mutation

Wehle, D. T.; Brown, E. A.; Stamenkovic, V.; Harsh, F.; Smith, S. E. P.

10.1101/2025.05.20.655155 — biochemistry — Posted on 2025-05-23

1605 Selection of nanobodies against liponanoparticle-embedded membrane proteins by yeast surface display

Dodge, G. J.; Knox, H. L.; Cho, B.; Imperiali, B.; Allen, K. N.

10.1101/2025.05.20.655075 — biochemistry — Posted on 2025-05-23

1606 A male-transmitted B chromosome undergoes strong meiotic drag in females

Ferree, P. M.; Cummings, J.; Garman, E.; Solomon, J.; Soriano Martinez, K.

10.1101/2025.05.20.655026 — genetics — Posted on 2025-05-23

1607 Temperature and genetic background drive mobilization of diverse transposable elements in a critical human fungal pathogen

Mackey, A. I.; Fraunfelter, V.; Shaltz, S.; McCormick, J.; Schroeder, C.; Perfect, J. R.; Feschotte, C.; Magwene, P. M.; Gusa, A. A.

10.1101/2025.05.19.654958 — genetics — Posted on 2025-05-23

1608 Wasabi leaf extract changes the expression levels of cytokine related genes in dermal papilla cells, which identified by the whole transcriptome

MATSUSAKA, H.; Kato, T. Y.; Nakai, M.; Bai, L.; Tomita, H.; Sugano, E.; Ozaki, T.; Okunishi, I.; Fukuda, T.

10.1101/2025.05.20.653605 — cell biology — Posted on 2025-05-23

1609 Calibration-free single-frame super-resolution fluorescence microscopy

Dostalova, A.; Vasinka, D.; Starek, R.; Jezek, M.

10.1101/2025.05.20.655080 — molecular biology — Posted on 2025-05-23

1610 Spectral theory of stochastic gene expression: a Hilbert space framework

Wu, B.; Grima, R.; Jia, C.

10.1101/2025.05.19.654994 — molecular biology — Posted on 2025-05-23

1611 Rab11FIP2 controls NLRP3 inflammasome activation through Rab11b

Gravastrand, C.; Yurchenko, M.; Kristensen, S.; Skjesol, A.; Chen, C.; Iqbal, Z.; Dahlen, K. R.; Nonstad, U.; Ryan, L.; Espevik, T.; Husebye, H.

10.1101/2025.05.19.654879 — immunology — Posted on 2025-05-23

1612 Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells

Thomas, J. R.; Haub, J.; Hunecke, A.; Yu, J.; Maier, P.; Zhang, M.; Pregler, B. E. F.; Raspe, M.; Streith, S.; Schneider, M.; Pizarro, C.; Skowasch, D.; Ginhoux, F.; Toma, M.; Martin, J.; Send, T.; Schlitzer, A.

10.1101/2025.05.19.654443 — immunology — Posted on 2025-05-23

1613 Monolithic Shape-Shifting Absorbable Implants for Long-Term Contraception

Li, J.; Clark, B. G.; Khosravi, P.; Cotter, C.; Liang, J. Y.; Ling, S. R.; Su, Y.; Qi, K. J.; Codreanu, F.; D'Orio, E.; Tan, I. T.; Green, J. E.; Murawska, K.; Lopes, A.; Muller, B. N.; Hayward, A. M.; Fabian, N.; Pettinari, A.; Schmidt, K.; Laidlaw, B.; Platero, M.; Guevara, A.; Bernstock, J. D.; Owyang, S. Y.; Chai, P. R.; Langer, R.; Traverso, G.

10.1101/2025.05.18.654764 — bioengineering — Posted on 2025-05-23

1614 Automated Diet Matrix Construction for Marine Ecosystem Models Using Generative AI

Spillias, S.; Fulton, E. A.; Boschetti, F.; Bulman, C.; Strzelecki, J.; Trebilco, R.

10.1101/2025.05.18.654761 — ecology — Posted on 2025-05-23

1615 Exploring the genetic factors of nitrogen use efficiency in potato

Mendoza-Bustamante, M. A.; Jimenez-Medrano, A. N.; Soto-Sedano, J. C.; Delgado-Nino, M. C.; Magnitskiy, S.; Ligarreto-Moreno, G. A.; Mosquera Vasquez, T.

10.1101/2025.05.18.654744 — genetics — Posted on 2025-05-23

1616 Hog1/p38 regulates the integrated stress response (ISR) and global transcriptomics changes in C. neoformans during oxidative stresschanges in C. neoformans during oxidative stress.

Goich, D.; Furfaro, J.; Panepinto, J.

10.1101/2025.05.19.654802 — genetics — Posted on 2025-05-23

1617 Larval diapause slows adult epigenetic ageing in an insect model, Nasonia vitripennis

Foley, E. E.; Thomas, C. L.; Kyriacou, C.; Mallon, E. B.

10.1101/2025.05.22.655466 — genetics — Posted on 2025-05-23

1618 Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38-beta activation

Bernardo, E.; Matesanz, N.; Torres, J. L.; Herrera-Melle, L.; Leiva-Vega, L.; Mora, A.; Rodriguez, M. E.; Hernandez-Cosido, L.; Nogueiras, R.; Arthur, S.; Nebreda, A. R.; Davis, R. R.; Marcos, M.; Sabio, G.

10.1101/2025.05.19.654793 — molecular biology — Posted on 2025-05-23

1619 Identification and optimization of trans-species reactive TfR1-binding VHH as tools for drug delivery across the blood brain barrier

David, M.; Cohen, R.; Beuzelin, D.; Ferracci, G.; Cresci, M.; Faucon, A.; Bakloul, K.; Godefroy, G.; Masse, M.; Mechioukhi, Y.; Girard, S. D.; Julien-Gau, I.; Boursery, C.; Fraisier, C.; Varini, K.; Thomas, M.; Jacquot, G.; Lecorche, P.; Serrano, B.; Romette, A.; Dangla Pelissier, G.; Godard, M.; Saillant, V.; Pruvost, T.; Sierocki, R.; Chames, P.; Kerfelec, B.; Temsamani, J.; KHRESTCHATISKY, M.

10.1101/2025.05.23.649291 — neuroscience — Posted on 2025-05-23

1620 Common pitfalls during model specification in psychophysiological interaction analysis

He, V.; Tahayori, B.; Vaughan, D. N.; Pardoe, H. R.; Jackson, G. D.; Tailby, C.; Abbott, D. F.; for the Australian Epilepsy Project Investigators,

10.1101/2025.05.22.655642 — neuroscience — Posted on 2025-05-23

1621 Evaluating the efficacy of LUMPY-NIL herbal powder, dermal Spray and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines

Kumar, A. H.; Sagar, V.; BM, R.

10.1101/2025.05.22.655490 — pharmacology and toxicology — Posted on 2025-05-23

1622 Immune stromal components impede biological effectiveness of carbon ion therapy in a preclinical model of pancreatic ductal adenocarcinoma

Swancutt, K. L.; Elghonaimy, E. A.; Nicholson, J. H.; Pop, L. M.; Siskh, B. J.; Polsdofer, E. M.; Hamilton, C.; Ruseck, A.; Davis, A. J.; Hannan, R.; Story, M. D.; Aguilera, T. A.

10.1101/2025.05.17.654632 — cancer biology — Posted on 2025-05-23

1623 Molecular Basis of Sodium Channel Inactivation

Liu, Y.; Galpin, J.; Ahern, C. A.; Bezanilla, F.

10.1101/2025.05.22.655422 — biophysics — Posted on 2025-05-23

1624 All-atom MD simulations of the HPV16 capsid

Antolinez, S.; Hadden-Perilla, J. A.

10.1101/2025.05.22.655575 — biophysics — Posted on 2025-05-23

1625 Clade-specific influences of glycans on the interactions between HIV-1 envelope and broadly neutralizing antibodies

Arandhara, M.; Kumar, Y.; Dixit, N. M.; Maiti, P. K.

10.1101/2025.05.20.655089 — biophysics — Posted on 2025-05-23

1626 Intrinsically Dominant Conformational Diversity in PDZ1 within the Tandem PDZ1-PDZ2 of Human Syntenin-1 Underlined by Crystal Structures.

Ando, N.; Hanazono, Y.; Sakuma, K.; Numoto, N.; Tenno, T.; Oshima, A.; Ito, N.; Hiroaki, H.

10.1101/2025.05.22.655525 — biophysics — Posted on 2025-05-23

1627 LeafyResNet: Fusarium Wilt Detection in Lettuce Using UAV RGB Imaging and Advanced Deep Learning Model

Hossain, K.; Stephanie, S.; Bucksch, A.

10.1101/2025.05.21.655416 — bioinformatics — Posted on 2025-05-23

1628 Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients

Briggs, J. K.; stroh, j. n.; Park, S.; Foreman, B.; Tymko, M.; Carr, J.; Sirlanci, M.; Ainslie, P.; Benninger, R. K.; Bennett, T. D.; Albers, D. J.

10.1101/2025.05.22.655581 — bioengineering — Posted on 2025-05-23

1629 Everything, everywhere, all at once - Surveillance and molecular epidemiology reveal Melissococcus plutonius is endemic among Michigan, US beekeeping operations of all sizes and present in some honey bee colonies year-round

Fowler, P. D.; Dhakal, U.; Chang, J. H.; Milbrath, M. O.

10.1101/2025.05.22.655465 — genomics — Posted on 2025-05-23

1630 Developmental constraints mediate the summer solstice reversal of climate effects on European beech bud set

Rebindaine, D.; Crowther, T. W.; Renner, S. S.; Wu, Z.; Zou, Y.; Mo, L.; Ma, H.; Bucher, R.; Zohner, C. M.

10.1101/2025.05.18.654771 — ecology — Posted on 2025-05-23

1631 The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis

Chen, X.; Li, H.; Deng, Y.; Meng, J.; Zhao, S.; Wooton-Kee, C. R.; Gao, X.; Dong, B.; Guan, D.; Scherer, P. E.; Zhu, Y.

10.1101/2025.05.19.654778 — molecular biology — Posted on 2025-05-23

1632 Intra-tumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ DC1 infiltration and activates anti-tumor immunity

Gorline, L.; Rosa do Carmo, F.; Bourdely, P.; Borneres, J.; Vaudiau, N.; Semervil, A.; Vetillard, M.; Ok, A.; Fiquet, O.; Andrade, M.; Theobald, H.; Collin, M.; Calmette, J.; Anselmi, G.; Fico, F.; Ginhoux, F.; Saveanu, L.; Helft, J.; Dalod, M.; Dusseaux, M.; Di Santo, J. P.; Hugues, S.; Guermonprez, P.

10.1101/2025.05.19.654717 — immunology — Posted on 2025-05-23

1633 Molecular phylogeny of Catenulida (Platyhelminthes) with special focus on their diversity in Poland

Tratkiewicz, K.; Baczynski, J.; Gasiorowski, L.

10.1101/2025.05.20.655055 — zoology — Posted on 2025-05-23

1634 Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cells

Wu, M. Y. M.; Rocamora, F.; Robinson, C.; Shin, S.; Toth, E. A.; Fuerst, T.; Maurya, S.; Lewis, N. E.

10.1101/2025.05.20.655202 — systems biology — Posted on 2025-05-23

1635 A multi-scale vascular atlas of blood vessels within the urinary bladder of male and female mice

Bowden, L. D.; Daglas, M.; Osborne, P. B.; Keast, J. R.

10.1101/2025.05.18.654773 — physiology — Posted on 2025-05-23

1636 Metformin inhibits PDGF signaling to suppress hyaluronan and IL-6 production in Thyroid Eye Disease

Husain, F.; Roztocil, E.; Patrick, C. C.; Feldon, S. E.; Woeller, C. F.

10.1101/2025.05.19.654298 — pathology — Posted on 2025-05-23

1637 Physical principles of phase-separation action on chromatin looping associated to pathogenic gene activation

Guha, S.; Fontana, A.; Abraham, A.; Bianco, S.; Esposito, A.; Conte, M.; Kundu, S.; Di Carluccio, C.; Vercellone, F.; Di Pierno, F.; Nicodemi, M.; Chiariello, A. M.

10.1101/2025.05.20.654944 — biophysics — Posted on 2025-05-23

1638 A Conserved Architecture of Allosteric Communications and Regulatory Hotspots in the KRAS Complexes with Diverse Binding Proteins Controls Mechanisms of Effector Mimicry and Allosteric Modulation : Atomistic Revelations from Molecular Simulations and Mutational Scanning of Binding Energetics and Allostery

Alshahrani, M.; Parikh, V.; Foley, B.; Verkhivker, G.

10.1101/2025.05.19.654934 — biophysics — Posted on 2025-05-23

1639 Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus

Qiao, L.; Alfonzo-Mendez, M.; Taraska, J. W.; Rangamani, P.

10.1101/2025.05.22.655576 — biophysics — Posted on 2025-05-23

1640 Stick-slip motion and universal statistics of cargo transport within living cells

Shen, Y.; Yan, C.; Huang, P.; Ori-McKenney, K. M.; Lai, P.-Y.; Tong, P.

10.1101/2025.05.19.654995 — biophysics — Posted on 2025-05-23

1641 Massively parallel quantification of mutational impact on IAPP amyloidformation

Badia, M.; Batlle, C.; Bolognesi, B.

10.1101/2025.05.19.654797 — biophysics — Posted on 2025-05-23

1642 Unmasking complex kinetics in viral entry by inferring hypoexponential models

Adenekan, O.; Kasson, P.

10.1101/2025.05.18.654751 — biophysics — Posted on 2025-05-23

1643 Validation of helical symmetry parameters in EMDB

Li, D.; Perez, M. M.; Zhang, X.; Li, J.; Jiang, W.

10.1101/2025.05.18.654508 — biophysics — Posted on 2025-05-23

1644 Multiscale simulations elucidate the mechanism of polyglutamine aggregation and the role of flanking domains in fibril polymorphism

Kulshrestha, A.; Phan, T. M.; Rizuan, A.; Mohanty, P.; Mittal, J.

10.1101/2025.05.19.654960 — biophysics — Posted on 2025-05-23

1645 De novo sequencing of complex glycans by ion mobility-mass spectrometry using a self-expanding reference database

Sastre Torano, J.; Vreugdenhil, J.; Vos, G. M.; Hooijschuur, K.; Vogelaar, S.; Klein, C.; Fjeldsted, J.; Stahl, B.; Boons, G.-J.

10.1101/2025.05.20.655041 — biochemistry — Posted on 2025-05-23

1646 Immune cell type divergence in a basal chordate

Scully, T. D.; Pickett, C. J.; Gort-Freitas, N. A.; Davidson, B.; Klein, A. M.

10.1101/2025.05.20.655184 — evolutionary biology — Posted on 2025-05-23

1647 Vitamin A is necessary for acquisition, but not for expression or progression, of CNS autoimmunity

Horai, R.; Zhou, R.; Bing, S. J.; Wloka, K.; Jittayasothorn, Y.; Duncan, T. E.; Mattapallil, M. J.; Silver, P. B.; Chan, C.-C.; Caspi, R. R.

10.1101/2025.05.18.654726 — immunology — Posted on 2025-05-23

1648 Cervical Mucus Viscoelasticity and Sperm Velocity are Correlated and Concentration-dependent In Vitro

Markovetz, M. R.; Wei, S.; Celluci, C.; Roberts, M.; Han, L.

10.1101/2025.05.18.654742 — biophysics — Posted on 2025-05-23

1649 Skin microbiome composite features in Atopic Dermatitis via integration analysis across cohorts

Wang, Y.; Liu, B.

10.1101/2025.05.18.653690 — bioinformatics — Posted on 2025-05-23

1650 SKiD: A Structure-Oriented Kinetics Database of Enzyme-Substrate Interactions

Roy, A.; Krishnan, S. R.; Pandey, N.; Srinivasan, R.

10.1101/2025.05.18.654770 — bioinformatics — Posted on 2025-05-23

1651 Unveiling the Biochemical Mechanisms of Aging and the Implications of Oxidative Stress on Cellular Senescence through Multi-Omics Analysis of Fibroblasts

Mandal, R.; Xie, N.; Alterovitz, G.

10.1101/2025.05.17.654671 — genomics — Posted on 2025-05-23

1652 Mapping the Regulatory Architecture of Circadian Clock Adaptation: A Genome-Wide eQTL Analysis in Drosophila melanogaster

Yair, M.; Fishman, B.; Aslan, M.; Tauber, E.

10.1101/2025.05.18.654706 — genomics — Posted on 2025-05-23

1653 Viral infection induces oxylipin chemical signaling at the end of a summer upwelling bloom: implications for carbon cycling.

Edwards, B. R.; Thamatrakoln, K.; Kranzler, C. F.; Ossolinski, J.; Fredricks, H.; Johnson, M. D.; Krause, J. W.; Bidle, K. D.; Van Mooy, B.

10.1101/2025.05.18.654734 — ecology — Posted on 2025-05-23

1654 Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

Harris, Z.; Korde, A.; Khoury, J.; Manning, E.; Stanley, G.; Mitchell, K.; Sun, Y.; Hu, B.; Shin, H. J.; Joerns, J.; Clark, B.; Placek, L.; Unutmaz, D.; Chun, H.; Sharma, L.; Sauler, M.; Rajagopalan, G.; Zhang, X.; Wang, H.; Kang, M.-J.; Koff, J.

10.1101/2024.05.24.595621 — cell biology — Posted on 2025-05-23

1655 The Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery.

Ramirez Moreno, M.; Cooper, A. S.; Lian, T.; Abtahi, S.; Liu, J. S.; Skoulakis, E. M.; Sivanantharajah, L.; Allan, D. W.; Mudher, A.

10.1101/2025.05.21.655273 — neuroscience — Posted on 2025-05-23

1656 Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer's disease

Essepian, N.; Yuan, S.; Roberts, R.; Sherman, E.; Gniadzik, W.; Wang, Q.; Erisir, A.; Jiang, L.

10.1101/2025.05.21.655370 — neuroscience — Posted on 2025-05-23

1657 Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking

Peters, K. Z.; Pedan, Z.; Agbude, R.; Woods, E. C.; Steele, O. G.; Suto, N.; Kinghorn, S. B.; Tsaponina, O.; Koya, E.

10.1101/2025.05.21.655312 — neuroscience — Posted on 2025-05-23

1658 CNVPipe: An enhanced pipeline for accurate analysis of copy number variation from whole-genome sequencing

Sun, J.; Wong, N. K.; Jiang, Z.; Luk, H.-M.; Lo, F. M.; Di, D.; Zhang, S.; Wong, R. C.; Jin, W.; Yip, S. P.; Huang, C.-L.

10.1101/2025.05.18.654763 — systems biology — Posted on 2025-05-23

1659 Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in Drosophila

Kosakamoto, H.; Okada, R.; Barker, C.; Seita, J.; Dohmae, N.; Imami, K.; Obata, F.

10.1101/2025.05.18.654697 — physiology — Posted on 2025-05-23

1660 Memo-Patho: Bridging Local-Global Transmembrane Protein Contexts with Contrastive Pretraining for Alignment-Free Pathogenicity Prediction

Bao, Y.; Liu, Z.; Zhao, F.; Li, W.; Jin, H.; Lin, G. N.

10.1101/2025.05.18.654712 — bioinformatics — Posted on 2025-05-23

1661 Accurate prediction of protein stability changes from single mutations using self-distillation and antisymmetric constraint strategies

Wang, W.; Zhou, Y.; HUANG, X.; Wu, Y.; Li, M.; Zhang, Y.

10.1101/2025.05.18.654422 — bioinformatics — Posted on 2025-05-23

1662 Life-history trade-offs explain local adaptation in Arabidopsis thaliana

Brachi, B.; Filiault, D.; Pisupati, R.; Dahan, T.; Igolkina, A.; Anastasio, A.; Box, M. S.; Duncan, S.; Karasov, T.; Kerdaffrec, E.; Merwin, L.; Morton, T.; Nizhynska, V.; Novikova, P. Y.; Rabanal, F. A.; Tsuchimatsu, T.; Sall, T.; Dean, C.; Holm, S.; Bergelson, J.; Nordborg, M.

10.1101/2025.05.18.654693 — genetics — Posted on 2025-05-23

1663 Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow

Yoval-Sanchez, B.; Guerrero, I.; Sosunov, S.; Chen, Q.; Ansari, F.; Siragusa, M.; Konrad, C.; Niatsetskaya, Z.; Stepanova, A.; Starkov, A.; Khruschev, S.; Magrane, J.; Nikitina, A. A.; Bereshchenko, O.; Witting, I.; Zhou, P.; Zhou, L.; Szibor, M.; Manfredi, G.; Gross, S.; Ten, V.; Galkin, A.

10.1101/2025.05.19.650489 — biochemistry — Posted on 2025-05-23

1664 Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission

Fischer, H. L.; Kline, C.; Duprex, W. P.; McCarthy, K.; Watkins, S.; Conway, J. F.; Ambrose, Z.

10.1101/2025.05.20.655126 — microbiology — Posted on 2025-05-23

1665 Aromatic Microbial Metabolite Hippuric Acid Potentiates Pro-Inflammatory Responses in Macrophages through TLR-MyD88 Signaling and Lipid Remodeling

Mirji, G.; Bhat, S. A.; El Sayed, M.; Reiser, S. K.; Gavara, S. P.; Ye, Y.; Miyamoto, T.; Liu, Q.; Goldman, A. R.; Kossenkov, A.; Zhang, N.; Shinde, R. S.

10.1101/2025.05.19.654724 — immunology — Posted on 2025-05-23

1666 From Structure to Immunogenicity: Decoding Correlated Dynamics atthe Peptide MHC interface to Understand TCR Recognition

Resink, T.; Sala, B. M.; Sun, R.; Han, X.; Alici, E.; Salazar-Onfray, F.; Sandalova, T.; Zhang, C.; Ljunggren, H.-G.; Achour, A.

10.1101/2025.05.18.654692 — immunology — Posted on 2025-05-23

1667 Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment

Adeshakin, A. O.; Shi, H.; Perry, S. S.; Sheppard, H.; Nguyen, P.; Sun, X.; Zhou, P.; Metais, J.-Y.; Cunningham, T.; KC, A.; Tian, L.; Peche, V.; Prater, M. S.; Langfitt, D. M.; Pruett-Miller, S. M.; Yustein, J. T.; Krenciute, G.; DeRenzo, C.; Chi, H.; Gottschalk, S.

10.1101/2025.05.20.650777 — immunology — Posted on 2025-05-23

1668 Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

Patil, M. J.; Hooper, J. S.; Kim, S.-H.; Bahia, P. K.; Pavelkova, N.; Nair, S. S.; Darcey, T. S.; Lurye, K. V.; Madaram, M.; Fiallo, J.; Hadley, S. H.; Taylor-Clark, T. E.

10.1101/2025.05.18.654723 — physiology — Posted on 2025-05-23

1669 Cargo recognition of Nesprin-2 by the dynein adapter Bicaudal D2 for a nuclear positioning pathway that is important for neuronal migration

Putta, S.; Rodriguez Castro, E. D.; Ali, M. Y.; Garcia Martin, J. M.; Zhao, X.; Sylvain, S.; Trybus, K. M.; Solmaz, S. R.

10.1101/2025.05.18.654709 — biophysics — Posted on 2025-05-23

1670 Maximum Entropy in the Gaussian Network Model: A Thermodynamic Reference State for Protein Dynamics

Erman, B.

10.1101/2025.05.18.654696 — bioinformatics — Posted on 2025-05-23

1671 Impact of Data Error on Phylogenetic Network Inference from Gene Trees Under the Multispecies Network Coalescent

Tamiji, M.; Sapoval, N.; Nakhleh, L.

10.1101/2025.05.18.654708 — bioinformatics — Posted on 2025-05-23

1672 Catalytic pocket-informed augmentation of enzyme kinetic parameters prediction via hierarchical graph learning

Luo, D.; Qu, X.; Wang, B.

10.1101/2025.05.18.654694 — bioinformatics — Posted on 2025-05-23

1673 The Bacterial Methylorubrum extorquens Product TS201 Induces Multiple Modes of Action to Reduce Insect Feeding Damage on Maize

Huynh, M.; Ho, K.-V.; Phillips, A.; Ernwall, A.; Ludwick, D.; Finke, D.; Lei, Z.; Jack, A.; Hibbard, B.; Breakfield, N.

10.1101/2025.05.22.655610 — plant biology — Posted on 2025-05-23

1674 Optimization of Bio-Orthogonal Non-Canonical Amino acid Tagging (BONCAT) for effective low-disruption labelling of Arabidopsis proteins in vivo

Hassan, N.; Braun, S.; Talasila, M.; Fahlman, R.; Uhrig, R. G.

10.1101/2025.05.22.655591 — plant biology — Posted on 2025-05-23

1675 An ancient plant symbiotic fungus with distinct features identified through advanced fluorescence and Raman imaging

Strullu-Derrien, C.; Wightman, R.; McDonnell, L. P.; Evans, G.; Fercoq, F.; Kenrick, P.; Ferrari, A. C.; Schornack, S.

10.1101/2025.05.22.655410 — plant biology — Posted on 2025-05-23

1676 Heterologous expression in Saccharomyces and Chlamydomonas reveals host-dependent activity of Brassica juncea fatty acid elongase1 isozymes

Patra, N.; Sarkar, S.; Maiti, M. K.

10.1101/2025.05.20.655142 — plant biology — Posted on 2025-05-23

1677 Genome editing of papaya using both Cas9 and Cas12a

Hasley, J.; Dinulong, R.-J.; Adhikari, A.; Christopher, D.; Tian, M.

10.1101/2025.05.22.655363 — plant biology — Posted on 2025-05-23

1678 Scaling law links plant growth variation to grain yield in wheat stands

Golan, G.; Vasseur, F.; Huang, Y.; Tan, K.; Sadras, V.; violle, c.; Schnurbusch, T.

10.1101/2025.05.19.654792 — plant biology — Posted on 2025-05-23

1679 Extending Specimens to save Plant DNA: structuring Department DNA collections in times of Biodiversity loss

Gonzalez-Toral, C.; Cires, E.

10.1101/2025.05.20.655165 — plant biology — Posted on 2025-05-23

1680 Limited Water Stress Triggers Adaptive Leaf Trait Response in Australian Commercial Rice Without Compromising Grain Yield and Quality

Fernando, Y.; Adams, M.; Kuhlmann, M.; Butardo, V.

10.1101/2025.05.21.655428 — plant biology — Posted on 2025-05-23

1681 Spatial analysis of cell patterning to aid genetic and phenotypic understanding of grass stomatal density: a case study in maize

Hodge, J. G.; Leakey, A. D. B.

10.1101/2025.05.21.655366 — plant biology — Posted on 2025-05-23

1682 Cryo-EM structure of plant urea transporter DUR3 reveals essential role of C-terminal domain in tetramer assembly and insights into proton-coupled transport

Wang, Y.; Green, M. N.; Lin, H.; Mazurek, C.; Lin, X.; Li, T.; Wang, R.; Li, W.; Zhao, X.; Feng, P.; Frommer, W. B.; Zhang, J.; Wudick, M. M.; Fan, M.

10.1101/2025.05.20.653754 — plant biology — Posted on 2025-05-23

1683 Genetic Gains from Sixty Years of Spring Wheat Breeding in the Northern Plains of the US

Gill, H. S.; Blecha, S.; Brault, C.; Glover, K.; Green, A.; Cook, J.; Lorenz, A.; Read, A. C.; Anderson, J. A.

10.1101/2025.05.21.655386 — plant biology — Posted on 2025-05-23

1684 Energy trade-offs under fluctuating light govern bioenergetics and growth in Chlamydomonas reinhardtii

Pfleger, A.; Arc, E.; Zhang, S.; Chaturvedi, P.; Antoine, E.; Gnaiger, E.; Ghatak, A.; Afjehi-Sadat, L.; Weckwerth, W.; Kranner, I.; Roach, T.

10.1101/2025.05.19.654497 — plant biology — Posted on 2025-05-23

1685 Transcriptome Profiling of Resistance Genes Analogs in Soybean's Cross-Tolerance to Water Limitation and Rust Stress

Husein, G.; Maia, T.; Castro-Moretti, F. R.; Krugel, J. D. K.; Amorim, L.; Mazzafera, P.; Nijveen, H.; Monteiro-Vitorello, C. B.

10.1101/2025.05.20.652543 — plant biology — Posted on 2025-05-23

1686 Mechanistic dissection of Candidatus Liberibacter Triggered Chronic Immune Disease

Huang, X.; Ma, W.; Wang, W.; Feng, Y.; Lamichhane, T.; Xu, J.; Sheo, P. S.; Achor, D. S.; Li, J.; Wang, Y.; Dalmendray, J. L.; Hu, Z.; Ribeiro, C.; Zhang, N.; Kunta, M.; Hansen, A. K.; Wang, N.

10.1101/2025.05.21.654963 — plant biology — Posted on 2025-05-23

1687 Tracking Lesion Growth in the Field: Imaging and Deep Learning Reveal Components of Quantitative Resistance

Anderegg, J.; Roth, L.; Zenkl, R.; McDonald, B. A.

10.1101/2025.05.20.655031 — plant biology — Posted on 2025-05-23

1688 The "Grove-First" Framework: Starting in the Grove to Find Therapies for Huanglongbing

Heck, M. L.; Larson, N. R.; Locatelli, G.; Cochrane, E.; Coradetti, S.; Hallman, L.; Johnson, L. M.; Estes, W. C.; Makar, A.; Demirden, N.; Pitino, M.; Shatters, R. G.; Adair, R. C.; Giles, F.; Fox, J.-P.; Stuehler, D. G.; Hodge, J.; Hoffman, J.; Blake, V.; Ulysse, L.; Ramirez-Barrera, L.; McKenna, R.; Thompson, L.; Bennett, L.; Larrea-Sarmiento, A.; Olmedo-Velarde, A.; Barkee, S.; Weeks-Purdy, C.; Zambon, F.; Shende, K.; Rossi, L.; D'Elia, T.; Ritenour, M.; Scully, B. T.; Niedz, R. P.

10.1101/2025.05.22.655577 — plant biology — Posted on 2025-05-23

1689 Chloroplast cpHsc70-1 interacts with VIPP1 C-terminal tail and controls VIPP1 oligomer disassembly in thylakoid membrane remodeling

Li, D.; Gachie, S. W.; Ozawa, S.-I.; Scholz, M.; Hippler, M.; Sakamoto, W.

10.1101/2025.05.20.655051 — plant biology — Posted on 2025-05-23

1690 The JAW-TCP-FUL genetic axis triggers an early reorientation of cell anisotropy to initiate and drive fertilization-dependent fruit elongation in Arabidopsis

Sharma, A. N.; G, K.; V, A.; S. S., N. S.; Perumadaraya, A. J.; Khadeeja, M.; Pradeep, D.; Basavaraju, S.; Chandra, K.; Rangarajan, A. N.; Nath, U.

10.1101/2025.05.20.655035 — plant biology — Posted on 2025-05-23

1691 m6A RNA methylation attenuates thermotolerance in Arabidopsis

Shekhawat, K.; Sheikh, A.; Nawaz, K.; Fatima, A.; Alzayed, W.; Nagaranjan, A. P.; Hirt, H.

10.1101/2025.05.22.655480 — plant biology — Posted on 2025-05-23

1692 A Chromosome-scale Reference Genome of Meloidogyne hapla reveals localized recombination hotspots enriched with Effector Proteins

Siddique, S.; Shakya, P.; Maulana, M. I.; Danchin, E.; Voogt, M. l.; van de Ruitenbeek, S. J. S.; Gimeno, J.; Taranto, A. P.; Coomer-Blundell, A.; Despot-Slade, E.; Mestrovic, N.; Mota, A. Z.; Dai, D.; Williamson, V. M.; Sterken, M. G.

10.1101/2025.05.21.654606 — plant biology — Posted on 2025-05-23

1693 Drone methods and educational resources for plant science and agriculture

Parker, T. A.; Celebioglu, B.; Watson, M.; Gepts, P.

10.1101/2025.05.19.654604 — plant biology — Posted on 2025-05-23

1694 MIK2 clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families

Maroschek, J.; Roesgen, Y.; Roessner, C.; Snoeck, S.; Schwechheimer, C.; Zipfel, C.; Hueckelhoven, R.

10.1101/2025.05.22.655486 — plant biology — Posted on 2025-05-23

1695 Single-cell metabolome and RNA-seq multiplexing on single plant cells

Kang, M.; Vu, A. H.; Casper, A. L.; Kim, R.; Wurlitzer, J.; Heinicke, S.; Yeroslaviz, A.; Caputi, L.; O'Connor, S. E.

10.1101/2025.05.20.655036 — plant biology — Posted on 2025-05-23

1696 AtDjB3 regulates Hsc70-1-mediated expression of the heat shock genes and thermotolerance in Arabidopsis

Satheesh, G.; Sengupta, I.; Sahi, C.

10.1101/2025.05.20.654906 — plant biology — Posted on 2025-05-23

1697 Metabolism of L-threonate, an ascorbate degradation product, requires a protein with L-threonate metabolizing domains in Arabidopsis

Yamamoto, K.; Yamashita, Y.; Hamada, T.; Miyagi, A.; Murayama, H.; Hamada, A.; Maruta, T.

10.1101/2025.05.18.654769 — plant biology — Posted on 2025-05-23

1698 New Callicarpa (Lamiaceae) taxa: Two species and a natural hybrid from Hahajima Island, Ogasawara Islands, Japan

Sugai, K.; SETSUKO, S.; Hayama, K.; Kato, H.

10.1101/2025.05.18.654768 — plant biology — Posted on 2025-05-23

1699 Embodiment of a functionally altered virtual arm in children and adults

Johannsen, L.; Pi, Y.; Thurlbeck, S.; Gillies, M.; Pan, X.; Cowie, D.

10.1101/2025.01.03.631079 — animal behavior and cognition — Posted on 2025-05-23

1700 The roles of dispersal limitation and pre-adaptation in shaping Paraburkholderia endosymbiont frequencies in social amoeba communities

DuBose, J. G.; Uhm, T.; Bowen, J.; Fiedorek, P.; Hoogshagen, M.; Haselkorn, T. S.; DiSalvo, S.

10.1101/2025.05.20.654931 — evolutionary biology — Posted on 2025-05-23

1701 Population dynamics of fruit flies (Diptera: Tephritidae) in a semirural area under subtropical monsoon climate of Bangladesh

Momen, M.; Hossain, M. A.; Seheli, K.; Hossain, M. F.; Bari, M. A.

10.1101/2024.09.22.614336 — ecology — Posted on 2025-05-23

1702 Comparison of FORCE trained spiking and rate neural networks shows spiking networks learn slowly with noisy, cross-trial firing rates.

Newton, T. R.; Nicola, W. R.

10.1101/2024.08.16.608322 — neuroscience — Posted on 2025-05-23

1703 Analysis of RyR2 distribution in HEK293 cells and mouse cardiac myocytes using 3D MINFLUX microscopy

Clowsley, A. H.; Meletiou, A.; Janicek, R.; Bokhobza, A. F. E.; Lucinskaite, E.; Bleuer, G.; Jansen, I.; Jones, P. P.; Louch, W. E.; Soeller, C.

10.1101/2023.07.26.550636 — physiology — Posted on 2025-05-23

1704 Interleukin-4 induces CD11c+ microglia leading to amelioration of neuropathic pain in mice

Kohno, K.; Shirasaka, R.; Hirose, K.; Masuda, T.; Tsuda, M.

10.1101/2024.12.05.627015 — pharmacology and toxicology — Posted on 2025-05-23

1705 Transposable elements drive species-specific and tissue-specific transcriptomes in human development

Zhang, Y.; She, J.; Hu, X.; Jin, Y.; Zhao, J.; Hou, S.; Tao, C.; Du, M.; Yang, E.

10.1101/2025.05.19.654775 — bioinformatics — Posted on 2025-05-23

1706 Evaluating computational tools for protein-coding sequence detection: Are they up to the task?

Champion, D.; Chen, T.-H.; Thomson, S.; Black, M. A.; Gardner, P. P.

10.1101/2024.05.16.594598 — bioinformatics — Posted on 2025-05-23

1707 DynaMiCs - Dynamic cell-type deconvolution ensembles for Mapping in mixed Conditions

Seifert, N.; Engel, L.; Tauschke, J.; Sterr, T.; Demmer, J.; Mensching-Buhr, M.; Voelkl, D.; Grellscheid, S. N.; Beissbarth, T.; Goertler, F.; Zacharias, H.; Altenbuchinger, M.

10.1101/2025.05.08.652868 — bioinformatics — Posted on 2025-05-23

1708 Interpretable trajectory inference with single-cell Linear Adaptive Negative-binomial Expression (scLANE) testing

Leary, J. R.; Dong, X.; Bacher, R.

10.1101/2023.12.19.572477 — bioinformatics — Posted on 2025-05-23

1709 Detecting ataxia using automated analysis of motor coordination and balance of mice on the balance beam

Wahl, L.; Kaiser, F. M. P.; Bentvelzen, M. F.; White, J. J.; Schonewille, M.; Badura, A.

10.1101/2023.07.03.547476 — animal behavior and cognition — Posted on 2025-05-23

1710 A catalog of ancient proxies for modern genetic variants

Brand, C. M.; Capra, J. A.

10.1101/2025.05.19.654975 — genomics — Posted on 2025-05-23

1711 Designing DNA With Tunable Regulatory Activity Using Score-Entropy Discrete Diffusion

Sarkar, A.; Kang, Y.; Somia, N.; Mantilla, P.; Zhou, J. L.; Nagai, M.; Tang, Z.; Zhao, C.; Koo, P.

10.1101/2024.05.23.595630 — genomics — Posted on 2025-05-23

1712 The CLAMP GA-binding transcription factor regulates heat stress-induced transcriptional repression by associating with 3D chromatin loops

Aguilera, J.; Duan, J.; Cortez, K.; Lee, R.; Aragon, A.; Ray, M.; Larschan, E.

10.1101/2023.10.08.561401 — genomics — Posted on 2025-05-23

1713 Directional selection failed to produce changes in olfactory Y-maze learning and memory but induced changes in climbing phenotypes

Hamlin, V. L.; Baumann, J.; Heffern, R.; Franke, A.; King, E. G.

10.1101/2025.05.18.654242 — genetics — Posted on 2025-05-23

1714 Lysosomes Signal through Epigenome to Regulate Longevity across Generations

Zhang, Q.; Dang, W.; Wang, M. C.

10.1101/2025.05.21.652954 — genetics — Posted on 2025-05-23

1715 Sampling Aware Ancestral State Inference

Song, Y.; Gill, I.; MacPherson, A.; Colijn, C.

10.1101/2025.05.20.655151 — evolutionary biology — Posted on 2025-05-23

1716 Pan-African metapopulation model explains Homo sapiens genetic and morphological evolution

Padilla-Iglesias, C.; Xue, Z.; Leonardi, M.; Paijmans, J. L. A.; Colucci, M.; Hovhannisyan, A.; Maisano-Delser, P.; Blanco-Portillo, J.; Ioannidis, A. G.; Lucarini, G.; Cerasoni, J. N.; Kandel, A. W.; Will, M.; Hallett, E. Y.; Lupo, K.; Scerri, E. M. L.; Crevecoeur, I.; Vinicius, L.; Migliano, A. B.; Manica, A.

10.1101/2025.05.22.655514 — evolutionary biology — Posted on 2025-05-23

1717 Ancient convergence with prokaryote defense and recent adaptations to lentiviruses in primates characterize the ancestral immune factors SAMD9s

Legrand, A.; Demeure, R.; Chantharath, A.; Rey, C.; Baltenneck, J.; Gilchrist, C. L.; Rocha, J. L.; Loyer, C.; Picard, L.; Cimarelli, A.; Steinegger, M.; Rousset, F.; Sudmant, P.; Etienne, L.

10.1101/2025.05.19.654893 — evolutionary biology — Posted on 2025-05-23

1718 Ghrelin and Mboat4 are lost in Serpentes

Pinto, R.; Ruivo, R.; Stiller, J.; Oliveira, D.; Castro, F.; da Fonseca, R.

10.1101/2025.05.18.653663 — evolutionary biology — Posted on 2025-05-23

1719 Genomic Insights into Derived Dwarfism and Exudivory in a Genus (Callithrix) of the World's Smallest Anthropoid Monkeys

Malukiewicz, J.; Boere, V.; Curi, N. H.; Dergam, J. A.; Igayara, C. S.; Moreira, S. B.; Nicola, P. A.; Passamani, M.; Pereira, L. C.; del Rosario, R. C. H.; Pissinatti, A.; Silva, D. L.; de Oliveira e Silva, I.; Ruiz-Miranda, C. R.; Cartwright, R. A.; Roos, C.; Stone, A. C.

10.1101/2025.05.19.654637 — evolutionary biology — Posted on 2025-05-23

1720 Tspecies, Rapid Optimization for Estimating Species Divergence Time Using Ks Distribution

Li, M.; Li, X.; Zhang, B.

10.1101/2025.05.18.654758 — evolutionary biology — Posted on 2025-05-23

1721 Cis-regulatory divergence and mate recognition in behaviourally isolated cricket species.

Yusuf, L. H.; Zhang, S.; Litzke, V.; Pulver, S. R.; Jones, T. M.; Bailey, N. W.

10.1101/2025.05.19.654830 — evolutionary biology — Posted on 2025-05-23

1722 Half as high for twice as long: male bias in the fertile-age sex ratio

Nitschke, M. C.; Hawkes, K.; Kim, P.

10.1101/2025.05.19.654849 — evolutionary biology — Posted on 2025-05-23

1723 Minimal overlaps in responses to insecticides between pollinator species

Witwicka, A.; Lopez-Osorio, F.; May, C.; Yeong, Y.; Wurm, Y.

10.1101/2025.05.19.654787 — evolutionary biology — Posted on 2025-05-23

1724 Dissecting fluctuating selection: A unified population and quantitative genetics

Tuyishimire, E.; Burke, M.; King, E. G.

10.1101/2025.05.19.654983 — evolutionary biology — Posted on 2025-05-23

1725 Implications of Endogenous Small Regulatory RNAs on Gene Silencing in Mollusks

Von Eiff, C.; Zancanela, B. S.; Gima, M.; Quito, K.; Kotikalapudi, M.; Valdivia, S.; Santos-Ortega, Y.; Flynt, A. S.

10.1101/2025.05.19.654968 — evolutionary biology — Posted on 2025-05-23

1726 A Developmental Mechanism Linking Heart Evolution and Congenital Defects

Kraus, N.; Placzek, F.; Samonov, R.; Nguyen, Q.; Metscher, B.

10.1101/2025.05.20.655032 — evolutionary biology — Posted on 2025-05-23

1727 Herbarium specimens reveal a constrained seasonal climate niche despite diverged annual climates across a wildflower clade

Bontrager, M.; Worthy, S. J.; Cacho, N. I.; Leventhal, L.; Maloof, J.; Gremer, J. R.; Schmitt, J.; Strauss, S. Y.

10.1101/2025.02.28.640808 — ecology — Posted on 2025-05-23

1728 Specimen-tailored "lived" climate reveals precipitation onset and amount best predict specimen phenology, but only weakly predict estimated reproduction across a clade

Bontrager, M. G.; Worthy, S. J.; Leventhal, L. C.; Maloof, J.; Gremer, J. R.; Schmitt, J.; Strauss, S. Y.

10.1101/2025.02.03.636077 — ecology — Posted on 2025-05-23

1729 Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice

Brachova, P.; Alvarez, N. S.

10.1101/2025.05.19.654918 — cell biology — Posted on 2025-05-23

1730 Deletion of the moe A gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

Escobar Doncel, A.; Patinios, C.; Campos, A.; Walter Costa, M. B.; Turkina, M. V.; Murace, M.; Staals, R. H. J.; Vignolini, S.; Dutilh, B. E.; Ingham, C.

10.1101/2025.01.13.632688 — microbiology — Posted on 2025-05-23

1731 A complex acoustical environment is necessary for maintenance and development in the zebra finch auditory pallium

Moseley, S. M.; Meliza, C. D.

10.1101/2025.05.22.655494 — neuroscience — Posted on 2025-05-23

1732 GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain

Lebedeva, A.; Kling, F.; Rakela, B.; Stryker, M. P.; Sun, Y. J.

10.1101/2025.05.21.655402 — neuroscience — Posted on 2025-05-23

1733 Decomposition of retinal ganglion cell electrical images for cell type and functional inference

Wu, E. G.; Rudzite, A. M.; Bohlen, M. O.; Li, P. H.; Kling, A.; Cooler, S.; Rhoades, C. E.; Brackbill, N.; Gogliettino, A. R.; Shah, N. P.; Madugula, S. S.; Sher, A.; Litke, A. M.; Field, G. D.; Chichilnisky, E. J.

10.1101/2023.11.06.565889 — neuroscience — Posted on 2025-05-23

1734 Early Indirect Neurogenesis transitions to late Direct Neurogenesis in mouse cerebral cortex development

Cardenas, A.; Celik, I.; Espinos, A.; Streicher, C.; Lopez-Gonzalez, L.; Del Valle Anton, L.; Fernandez, V.; Amin, S.; Negri, E.; Fernandez Ortuno, E.; Hippenmeyer, S.; Borrell, V.

10.1101/2025.05.22.655488 — neuroscience — Posted on 2025-05-23

1735 The association between resting state aperiodic activity and Research Domain Criteria Social Processes in young neurotypical adults

Ford, T. C.; Hill, A. T.; Parrella, N.-F.; Kirkovski, M.; Donaldson, P.; Enticott, P. G.

10.1101/2023.09.19.558536 — neuroscience — Posted on 2025-05-23

1736 A two-dimensional space of linguistic representations shared across individuals

Tuckute, G.; Lee, E. J.; Ou, Y.; Fedorenko, E.; Kay, K.

10.1101/2025.05.21.655330 — neuroscience — Posted on 2025-05-23

1737 Untamed: Unconstrained Tensor Decomposition and Graph Node Embedding for Cortical Parcellation

Liu, Y.; Li, J.; Wisnowski, J. L.; Leahy, R. M.

10.1101/2024.01.05.574423 — neuroscience — Posted on 2025-05-23

1738 The shape of attention: How cognitive goals sculpt cortical representation of speech.

Huet, M.-P.; Elhilali, M.

10.1101/2025.05.22.655464 — neuroscience — Posted on 2025-05-23

1739 Diencephalic and white matter knock-on effects in hippocampal amnesia - why they matter

Argyropoulos, G. P. D.; Aggleton, J. P.; Butler, C. R.

10.1101/2025.05.21.655297 — neuroscience — Posted on 2025-05-23

1740 Gaming the Metrics? Bibliometric Anomalies and the Integrity Crisis in Global University Rankings

Meho, L. I.

10.1101/2025.05.09.653229 — scientific communication and education — Posted on 2025-05-23

1741 Parallel adaptation and admixture drive the evolution of virulence in the grapevine downy mildew pathogen

DVORAK, E.; DUMARTINET, T.; MAZET, I. D.; CHATAIGNER, A.; Paineau, M.; CANTU, D.; MESTRE, P.; FOULONGNE-ORIOL, M.; DELMOTTE, F.

10.1101/2025.05.18.654733 — plant biology — Posted on 2025-05-23

1742 RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

Ayad, N. G.; Jangde, N.; Lee, M. H.; Ruiz, L.; Egan, I.; Jermakowicz, A.; Wynn, D.; Goka, E.; Lippman, M.; Robbins, D. J.

10.1101/2025.05.22.655563 — pharmacology and toxicology — Posted on 2025-05-23

1743 Combinatorial mutagenesis of N-terminal sequences reveals unexpected and expanded stability determinants of the Escherichia coli N-degron pathway

Sen, S.; Corrado, N.; Tiso, A.; Kho, K. K.; Kunjapur, A. M.

10.1101/2025.05.22.655665 — synthetic biology — Posted on 2025-05-22

1744 Cystathionine γ Lyase Deletion Enhances Corpus Cavernosum Contraction via Thromboxane A2 and Neurogenic Pathways Without Affecting Endothelial Function

Azeez, T. A.; Pierre, C. J.; Ihrig, C. M.; Chelko, S. P.; Muller-Delp, J. M.; La Favor, J. D.

10.1101/2025.05.17.654668 — physiology — Posted on 2025-05-22

1745 3D Biomimetic Liver Cancer Model: Diethylnitrosamine-Induced Proteomic Dysregulations in Stromal-Epithelial Milieu

Salihah, S.; Bibi, B.; Khan, S.; Tahir, M.; Mahmood, S.; Vosough, M.; Razzoli, A.; Sidoli, S.; Gul, A.

10.1101/2025.05.17.654447 — cancer biology — Posted on 2025-05-22

1746 Antibiotics-induced conformational heterogeneity of a multidrug transporter revealed by single-molecule FRET

Maklad, H. R.; Kache, T.; Roth, A.; Mamkaeva, M.; Govaerts, C.; Hendrix, J.; Martens, C.

10.1101/2025.05.17.654648 — biophysics — Posted on 2025-05-22

1747 PCAGP, a parallel convolutional attention network-based method for crop genomic prediction

Peng, W.; Sheng, Y.; Zhou, Y.; Chai, L.

10.1101/2025.05.17.654636 — bioinformatics — Posted on 2025-05-22

1748 Integrated transcriptomic analyses identifies host-targeting repurposing drugs for hepatitis C virus infection and related hepatocellular carcinoma

Kamboj, S.; Kumar, M.

10.1101/2025.05.17.654645 — bioinformatics — Posted on 2025-05-23

1749 High Spatiotemporal Imaging of Protein Secretion During Cell to Cell Communication via Integrative Biosensing Nanoplasmonic Array

Park, Y.; Ray, P.; Kurabayashi, K.

10.1101/2025.05.17.654581 — bioengineering — Posted on 2025-05-22

1750 NIR Phosphorescent Oxygen Sensors in Natural Hydrogel Matrices

Saleem, W.; Jeevarathinam, A. S.; Lindblade, R. E.; McShane, M. J.

10.1101/2025.05.17.654688 — bioengineering — Posted on 2025-05-23

1751 Comparing analytical protocols for identifying causes of population changes

Malinowska, K.; Wawrzynowicz, M.; Markowska, K.; Chodkiewicz, T.; Butler, S.; Kuczynski, L.

10.1101/2025.05.17.654658 — ecology — Posted on 2025-05-22

1752 High-severity fires undermine resilience of black spruce-dominated boreal forests in eastern North America

Fortin, S.; Boucher, Y.; Bergeron, Y.; Simard, M.; Arseneault, D.; Asselin, H.; Barette, M.; Danneyrolles, V.; Gauthier, S.; Girard, F.; Girardin, M.; Parisien, M.-A.; Thiffault, N.; Valeria, O.

10.1101/2025.05.17.654490 — ecology — Posted on 2025-05-23

1753 Worldwide spread of Hylurgus ligniperda (Coleoptera: Scolytinae), and the potential role of bridgehead invasions

Brockerhoff, E. G.; Schläfli, L.; Cornejo, C.; Kappeler, J.; Orbach, J.; Tiefenbacher, A.; Kupper, Q.; Avtzis, D.; Branco, M.; Carnegie, A. J.; Chase, K. D.; Corley, J.; Faccoli, M.; Gilbride, E.; Hurley, B. P.; Jactel, H.; Kerr, J. L.; Kirichenko, N. I.; Knizek, M.; Lakatos, F.; Lantschner, V.; Martinez, G.; Meurisse, N.; Poisson, M. A.; Poloni, A.; Rassati, D.; Riba-Flinch, J. M.; Ribeiro-Correia, J. P.; Shi, J.; Smith, D.; Somers, L.; Yuan, Y.; Prospero, S.

10.1101/2025.05.17.654641 — ecology — Posted on 2025-05-23

1754 A novel role for UPF1 in safeguarding DNA replication in S phase and beyond.

Walne, T.; Maple, L.; Li, N.; Christie, I. N.; Smythe, C.; Thompson, R. H.

10.1101/2025.05.22.655556 — cell biology — Posted on 2025-05-22

1755 Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli

Gresko, N. P.; Padovano, V.; Berg, P. M.; Ong, A. C. M.; Somlo, S.; Scholz, N.; Langenhan, T.; Caplan, M. J.

10.1101/2025.05.21.655326 — cell biology — Posted on 2025-05-22

1756 Genetic heterogeneity in Taenia solium cysticerci among naturally infected pigs revealed by microsatellite markers and associated epidemiological risk factors.

Sharma, R.; Aulakh, R. S.; Bagicha, B. S.; Sharma, R.; Saini, R. S.

10.1101/2025.05.21.655296 — molecular biology — Posted on 2025-05-22

1757 Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids

Kaur, G.; Crawford, S. E.; Ramani, S.; Ayyar, B. V.; Boussattach, A. I.; Zeng, X.-L.; Atmar, R. L.; Nguyen-Phuc, H.; Coarfa, C.; Estes, M. K.

10.1101/2025.05.22.655571 — microbiology — Posted on 2025-05-22

1758 The vacuolar protein 8 (Vac8) homolog in Cryptococcus neoformans plays conserved and unique roles in vacuolar and cellular morphology, impacting important stress responses and virulence traits

Stuckey, P. V.; Marine, J.; Figueras, M.; Collins, A.; Santiago-Tirado, F. H.

10.1101/2025.05.22.655601 — microbiology — Posted on 2025-05-22

1759 ANTIMICROBIAL ACTIVITIES OF VERNONIA AMYGDALINA AGAINST BIOFILM-FORMING MICROBES

Ebiloma, S.; Nwachuckwu, N. C.; Uchendu, N.; Okereke, H.

10.1101/2025.05.22.655479 — microbiology — Posted on 2025-05-22

1760 Pneumococcal H2O2 Reshapes Mitochondrial Function and Reprograms Host Cell Metabolism

Scasny, A.; Alibayov, B.; Hoang, N. H.; Vidal, A. G.; Takeshita, K.; Bengten, E.; Baez, A.; Li, W.; Hosler, J.; Warncke, K.; Edwards, K. S.; Vidal, J. E.

10.1101/2025.05.22.655446 — microbiology — Posted on 2025-05-22

1761 Inhibitory activities of monoclonal antibodies against Staphylococcus aureus Clumping factor A

Banerjee, B.; Emolo, C.; Shi, M.; Al Fardan, A.; Pius, T.; McAdow, M.; Schneewind, O.; Missiakas, D.

10.1101/2025.05.21.655433 — microbiology — Posted on 2025-05-22

1762 Peptaibiotic-inspired antimicrobials based on human cathelicidin

Albin, J. S.; Vithanage, D. A.; Pentelute, B. L.

10.1101/2025.05.22.655621 — microbiology — Posted on 2025-05-22

1763 Host range and ARG dissemination are shaped by distinct survival strategies of conjugative plasmids

Ono, R.; Konno, N.; Nishimura, Y.; Furusawa, C.

10.1101/2025.05.22.655438 — microbiology — Posted on 2025-05-22

1764 CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes

Barman, S.; Räuber, S.; Eisenhut, K.; Esser, D.; van Duijn, M.; Scharf, M.; Herrera-Rivero, M.; Disse, P.; Jonas, M.; Pul, D.; Heming, M.; Müller-Miny, L.; Paunovic, M.; Strippel, C.; Haholu, E.; Kaufmann, E.; Dargvainiene, J.; Kahl, S.; Ringelstein, M.; Bindels, E.; Wiendl, H.; Stoecklein, N. H.; Fischer, J.; Goebels, N.; Komorowski, L.; Roden, M.; Rossi, A.; Stoll, M.; Meuth, S. G.; Titulaer, M. J.; Leypoldt, F.; Meyer zu Hörste, G.; Thaler, F.; Melzer, N.

10.1101/2025.05.18.654720 — immunology — Posted on 2025-05-22

1765 Meta-analytic evidence for distinct neural correlates of conditioned vs. verbally induced placebo analgesia

Spisak, T.; Hartmann, H.; Zunhammer, M.; Kincses, B.; Wiech, K.; Wager, T. D.; Bingel, U.; Placebo Imaging Consortium,

10.1101/2025.05.21.655287 — neuroscience — Posted on 2025-05-22

1766 Family matters! The influence of family, peers, mentors, and professors on STEM college students motivational beliefs and career decision making

Tuma, T.

10.1101/2025.01.22.633242 — scientific communication and education — Posted on 2025-05-22

1767 Three-dimensional single-particle reconstruction by atomic force microscopy allows rapid structural-based validation of recombinant SARS-CoV-2 Spike protein from a single topology image

Lutter, L.; Beal, D. M.; Stanley, M.; Roobol, J.; Martin, S.; Budge, J. D.; Lee, P. E.; Nemoto-Smith, E.; Brown, I.; Warren, M. J.; Smales, C. M.; Xue, W.-F.

10.1101/2025.05.20.655128 — biophysics — Posted on 2025-05-22

1768 SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1-XBP1 Signaling Under ER Stress

Ying, Q.; Chen, Y.; Shen, L.; Xu, Y.; Tian, R.

10.1101/2025.05.20.655206 — genetics — Posted on 2025-05-22

1769 Grid partitioning image analysis for bacterial cell aggregates

Ohara, Y.; Yoshimoto, S.; Hori, K.

10.1101/2025.05.22.655429 — microbiology — Posted on 2025-05-22

1770 Detection and genetic characterization of pigeon gammacoronavirus

Kobayashi, H.; Kishimoto, M.; Imai, S.; Orba, Y.; Sawa, H.; Horie, M.

10.1101/2025.05.22.655467 — microbiology — Posted on 2025-05-22

1771 Mimicry of the LL-37 N-terminus enhances the activity of short human cathelicidin derivatives

Albin, J. S.; Vithanage, D. A.; Johnson, C.; Pentelute, B. L.

10.1101/2025.05.22.655619 — microbiology — Posted on 2025-05-22

1772 PMA-qPCR: ACCELERATING THE MARKET RELEASE OF HIGH-QUALITY BRADYRHIZOBIUM DIAZOEFFICIENS INOCULANTS

Cap, M.; Frydman, C.; Galinanes, A.; Aranguiz, C.; Faranco, I.; Andriolo, L.; Parreno, V.; Mozgovoj, M.

10.1101/2025.05.22.655534 — microbiology — Posted on 2025-05-22

1773 A conserved region T-cell vaccine for Sarbecoviruses

Escarra-Senmarti, M.; Brockhurst, J.; Maxwell, a. R.; Godwin, t.; Zhang, t.; Chen, y.; Um, P. K.; Danilova, L.; Hsu, W.-c.; Lin, C. T.; Hanke, T.; Bishai, W. R.; Pekosz, A.; Brayton, C.; Korber, B.; rosario, M.

10.1101/2025.05.20.654373 — immunology — Posted on 2025-05-22

1774 Peptide Barcodes for miRNA activity assessment in mammalian cells

Cheras, V.; Rousounelou, E.; Aschenbach, J.-L.; Panke, S.; Benenson, Y.

10.1101/2025.05.22.655559 — synthetic biology — Posted on 2025-05-22

1775 Postural test to differentiate primary aldosteronism from low-renin hypertension

Tizianel, I.; Pagin, E.; Ragazzi, E.; Madinelli, A.; Censi, S.; Sabbadin, C.; Mantero, F.; Mian, C.; Barbot, M.; Antonelli, G.; Ceccato, F.

10.1101/2025.05.16.654625 — physiology — Posted on 2025-05-22

1776 The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice

Falvey, A.; Palandira, S. P.; Chaudhry, S.; Tynan, A.; Consolim-Colombo, F. M.; Metz, C. N.; Brines, M.; Chang, E. H.; Chavan, S. S.; Tracey, K. J.; Pavlov, V. A.

10.1101/2025.05.17.654675 — physiology — Posted on 2025-05-22

1777 Mechanisms and control of a novel vocalization: the singing mouse song is a whistle that depends on air sac inflation

Smith, S. K.; Hakansson, J.; Frazel, P.; Long, M. A.; Elemans, C. P.; Phelps, S. M.

10.1101/2025.05.16.654575 — physiology — Posted on 2025-05-22

1778 Spatial Sorting of Soft and Stiff Bacteria in the Human Colon

Tozzi, A.

10.1101/2025.05.17.654646 — biophysics — Posted on 2025-05-22

1779 Integrating experiments and simulations to unravel coacervate-membrane interactions: Insights into de-mixing and morphology modulation

Mondal, S.; Mangiarotti, A.; Dimova, R.; Cui, Q.

10.1101/2025.05.16.654554 — biophysics — Posted on 2025-05-22

1780 Rapid and Efficient Quality Control Analysis of Isolated Mitochondria by Interferometric Light Microscopy

MOZAFARI, S.; RIBES, C.; AYOLLO, D.; GAZEAU, F.; SILVA, A. K. A.; AUBERTIN, K.

10.1101/2025.05.17.654679 — biophysics — Posted on 2025-05-22

1781 Decomposing Predictive Information in Social Dynamics

Kawano, A.; O'Shaughnessy, L.; Neiman, R.; Deligkaris, K.; Rodriguez, L. C.; Masai, I.; Stephens, G. J.

10.1101/2025.05.16.654393 — biophysics — Posted on 2025-05-22

1782 Endosome transcriptomics reveal trafficking of Cajal bodies into multivesicular bodies

Singh, J.; Williams, J. K.; Elliott, Q.; Jhawar, R.; Ferguson, L.; Collins, K.; Schekman, R.

10.1101/2025.05.22.655499 — biochemistry — Posted on 2025-05-22

1783 Turbulence orchestrates actin-mitochondria dynamics to preserve GPIbα and support iPSC-derived platelet biogenesis

Nakamura, E.; Harada, Y.; Nakamura, S.; Fujio, K.; De Wispelaere, K.; Thys, C.; Freson, K.; Yamamoto, T.; Sawaguchi, A.; Suetsugu, S.; Eto, K.

10.1101/2025.05.22.655481 — cell biology — Posted on 2025-05-22

1784 Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission

Fischer, H. L.; Kline, C.; Duprex, W. P.; McCarthy, K.; Watkins, S.; Conway, J. F.; Ambrose, Z.

10.1101/2025.05.20.655126 — microbiology — Posted on 2025-05-22

1785 SARS-CoV-2 Nonstructural Protein 3 Remodels the Phosphorylation of Target Proteins via Protein-Protein Interactions

Yang, H.; Peng, D.; Martinez-Sobrido, L.; Ye, C.

10.1101/2025.05.20.655086 — microbiology — Posted on 2025-05-22

1786 Cetacean coronavirus spikes highlight S glycoprotein structural plasticity

Hulswit, R. J. G.; Shamorkina, T. M.; van der Lee, J.; Rosman, F.; Wetzels, L. S.; van Kuppeveld, F. J. M.; Snijder, J.; Bosch, B. J.; Hurdiss, D. L.

10.1101/2025.05.20.655071 — microbiology — Posted on 2025-05-22

1787 Separability of antibacterial and membranolytic activity in the human host defense peptide LL-37

Albin, J. S.; Vithanage, D. A.; Vuong, W.; Johnson, C.; Yonker, L. M.; Pentelute, B. L.

10.1101/2025.05.22.655608 — microbiology — Posted on 2025-05-22

1788 The EPS-I exopolysaccharide transforms Ralstonia wilt pathogen biofilms into viscoelastic fluids for rapid dissemination in planta

Cope-Arguello, M.; Li, J.; Konkel, Z.; Aoun, N.; Cowell, T.; Wagner, N.; Chan, A. L. H.; Chu, L. T.; Wang, S.; Carter, M. D.; Allen, C.; Caverly, L. J.; Bui, L.; DeAngelis, K. M.; Wargo, M. J.; Tran, T. M.; Jacobs, J. M.; Manikantan, H.; Lowe-Power, T. M.

10.1101/2025.05.22.655385 — microbiology — Posted on 2025-05-22

1789 Intracellular formate is a critical mediator of the antimicrobial fate of Salmonella Typhimurium Against meropenem and ciprofloxacin

Chakravortty, D.; Mukherjee, D.; Wagle, S. V.; Ghosh, P.; Biswas, A.

10.1101/2025.05.22.655487 — microbiology — Posted on 2025-05-22

1790 Tuning the interaction of a ParA-type ATPase with its partner separates bacterial organelle positioning from partitioning

Byrne, J. A.; Swasthi, H. M.; Hu, L.; Azaldegui, C. A.; Liu, J.; Vecchiarelli, A. G.

10.1101/2025.05.22.655647 — microbiology — Posted on 2025-05-22

1791 Age-dependent gut microbiota dynamics and their association with male fitness traits in Drosophila melanogaster

Sultanova, Z.; Dönertas, H. M.; Hita, A.; Aguilar, P.; Dag, B.; Lucas-Lledo, J. I.; Latorre, A.; Carazo, P.

10.1101/2025.05.22.655607 — microbiology — Posted on 2025-05-22

1792 Penicillium hordei acidification precipitates Bacillus subtilis lipopeptides to evade inhibition

Vertot, M.; Schostag, M. D.; Andersen, A. J.; Frisvad, J. C.; Lozano-Andrade, C. N.; Jarmusch, S. A.

10.1101/2025.05.21.655424 — microbiology — Posted on 2025-05-22

1793 WITHDRAWN: A new alignment-free method: Subsequence Correlation Coefficient Vector(SCCFV) for influenza A comparison using virus genomes

He, L.; Yu, Z.; Wu, X.; Zhu, Y.; Han, S.; Yau, S. S.- T.

10.1101/2024.07.12.603253 — bioinformatics — Posted on 2025-05-22

1794 WITHDRAWN:The NIH BRAIN Initiative's Experiment in Team Research

Bader, F.; David, K. K.; Lantz, C.; Rangel-Gomez, M.; Gebrehiwet, H.; Peng, G. C. Y.; Gnadt, J.

10.1101/2025.02.07.635683 — neuroscience — Posted on 2025-05-22

1795 Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation.

Corazza, M. F.; Turovets, S.; Muravchik, C. H.

10.1101/2025.05.16.654079 — bioengineering — Posted on 2025-05-22

1796 Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans

Hall, A. N.; Morton, E.; Walters, R.; Cuperus, J. T.; Queitsch, C.

10.1101/2025.03.21.644675 — genomics — Posted on 2025-05-22

1797 Charting Taxa in Amanita Section Amidella (Basidiomycota : Amanitaceae)

Oliveira, P.; Arraiano-Castilho, R.

10.1101/2024.07.30.605754 — evolutionary biology — Posted on 2025-05-22

1798 Network-based representation learning reveals the impact of age and diet on the gut microbial and metabolomic environment of U.S. infants in a randomized controlled feeding trial

Price, A.; Rasolofomanana Rajery, S.; Manpearl, K.; Robertson, C. E.; Krebs, N. F.; Frank, D. N.; Krishnan, A.; Hendricks, A. E.; Tang, M.

10.1101/2024.11.01.621627 — microbiology — Posted on 2025-05-22

1799 Combinative protein expression of immediate early genesc-Fos, Arc, and Npas4 along aversive- and reward-related neural networks

Arai, M.; Osanai, H.; Snell, C. C.; Kitamura, T.; Ogawa, S. K.

10.1101/2025.04.21.649441 — neuroscience — Posted on 2025-05-22

1800 Change point based dynamic functional connectivity estimation outperforms sliding window and static estimation for classification of early mild cognitive impairment in resting-state fMRI

Ondrus, M.; Cribben, I.

10.1101/2025.05.16.654552 — neuroscience — Posted on 2025-05-22

1801 Sex dependent effects of amyloidosis on functional network hub topology is associated with downregulated neuronal gene signatures in the APPswe/PSEN1dE9 double transgenic mouse

Simon, Z. D.; McFarland, K. N.; Golde, T. E.; Chakrabarty, P.; Febo, M.

10.1101/2024.05.13.593982 — neuroscience — Posted on 2025-05-22

1802 Shared Hierarchical Representations Explain Temporal Correspondence Between Brain Activity and Deep Neural Networks

Lutzow Holm, E.; Marraffini, G.; Fernandez Slezak, D.; Tagliazucchi, E.

10.1101/2025.05.19.655003 — neuroscience — Posted on 2025-05-22

1803 ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

Johnson, R. M.; Wang, S.; Carozza, J. A.; Fernandez, D.; Scicinski, J.; Verity, N. A.; Mardjuki, R.; Cao, X.; Papkoff, J.; Ray, N.; Li, L.

10.1101/2025.05.18.654655 — cancer biology — Posted on 2025-05-22

1804 Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli

Hofmann, J. L.; Yang, T. S.; Sunol, A. M.; Zia, R. N.

10.1101/2023.04.14.536948 — biophysics — Posted on 2025-05-22

1805 Differential Analysis Reveals Isoform Switching Following Pneumococcal Vaccination

Kil, Y.; Pachter, L. S.

10.1101/2025.03.09.642237 — bioinformatics — Posted on 2025-05-22

1806 Draft genome and transcriptomic sequence data of three invasive insect species

Lombaert, E.; Klopp, C.; Blin, A.; Annonay, G.; Iampietro, C.; Lluch, J.; Sallaberry, M.; Valiere, S.; Poloni, R.; Joron, M.; Deleury, E.

10.1101/2024.12.02.626401 — genomics — Posted on 2025-05-22

1807 New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster

Rai, M.; Okah, P.; Shefali, S. A.; Fitt, A. J.; Shen, M. Z.; Molomjamts, M.; Pepin, R.; Nemkov, T.; D'Alessandro, A.; Tennessen, J.

10.1101/2025.03.27.645621 — genetics — Posted on 2025-05-22

1808 Phylogenomic analyses reveal that Panguiarchaeum is a clade of genome-reduced Asgard archaea within the Njordarchaeia

Huang, W.-C.; Probst, M.; Hua, Z.-S.; Szantho, L. L.; Szollosi, G. J.; Ettema, T.; Rinke, C.; Williams, T. A.; Spang, A.

10.1101/2025.02.13.637844 — evolutionary biology — Posted on 2025-05-22

1809 Bona fide hematopoietic stem cells in zebrafish originate from the supra-intestinal artery

Feng, S.; Qu, R.; He, Y.; Huang, T.; Wang, Y.; Trinh, T. H.; Cheng, K.; Zhao, S.; Huang, Y.; Zhu, H.; He, S.; Wen, Z.

10.1101/2025.05.20.655066 — developmental biology — Posted on 2025-05-22

1810 Investigating pancreatic β cell membrane epitopes using unbiased cell-based Fab-phage display

Moursli, Y.; Poitras, C.; Coulombe, B.

10.1101/2025.03.29.645157 — molecular biology — Posted on 2025-05-22

1811 Investigating Factors Driving Shifts in Subtype Dominance within H5Nx Clade 2.3.4.4b High-Pathogenicity Avian Influenza viruses

Billington, E.; Di Genova, C.; Warren, C. J.; Thomas, S. S.; Johnson, S.; Riccio, S.; De Silva, D.; Peers-Dent, J.; Temperton, N. J.; da Costa, K.; Byrne, A. M. P.; Airey, M.; Schlachter, A.-L.; Yang, J.; Nunez, A.; Iqbal, M.; Slomka, M. J.; Brown, I. H.; Banyard, A. C.; James, J.

10.1101/2025.04.23.650244 — microbiology — Posted on 2025-05-22

1812 The control of overt and covert attention across two nodes of the attention-control network

Polosecki, P.; Steenrod, S. C.; Stemmann, H.; Freiwald, W. A.

10.1101/2024.01.05.574406 — neuroscience — Posted on 2025-05-22

1813 BRAPH 2: a flexible, open-source, reproducible, community-oriented, easy-to-use framework for network analyses in neurosciences

Chang, Y.-W.; Zufiria-Gerboles, B.; Gomez-Ruiz, P. E.; Canal-Garcia, A.; Zhao, H.; Mijalkov, M.; Braga Pereira, J.; Volpe, G.

10.1101/2025.04.11.648455 — neuroscience — Posted on 2025-05-22

1814 Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

Shevtsova, N. A.; Lockhart, A. B.; Rybak, I. A.; Magnuson, D. S.; Danner, S. M.

10.1101/2025.05.17.654682 — neuroscience — Posted on 2025-05-22

1815 Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors

Niederau, P. A.; Weilguny, M. C.; Chamas, S.; Turney, C. E.; Parsons, J.; Rodriguez-Franco, M.; Hoernstein, S. N. W.; Decker, E. L.; Toft Simonsen, H.; Reski, R.

10.1101/2025.02.06.636855 — plant biology — Posted on 2025-05-22

1816 Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response

Federmann, S.; Westerhoff, M.; Reichert, A. S.; Fritz, G.

10.1101/2025.05.15.654253 — pharmacology and toxicology — Posted on 2025-05-22

1817 BMI-1 Modulation and Trafficking During M Phase in Diffuse Intrinsic Pontine Glioma

Umaru, B.; Mishra, D.; Senthil Kumar, S.; Pang, H.-H.; Devine, B.; Khan, K.; Drissi, R.

10.1101/2025.05.16.654605 — cancer biology — Posted on 2025-05-22

1818 Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer

Wang, X.; Duan, M.; Su, P.-L.; Li, J.; Krull, J.; Jin, J.; Chen, H.; Sun, Y.; Wu, W.; He, K.; Carpenter, R.; Zhang, C.; Cao, S.; Xu, D.; Wang, G.; Li, L.; Xin, G.; Carbone, D. P.; Li, Z.; Ma, Q.

10.1101/2025.05.16.654579 — bioinformatics — Posted on 2025-05-22

1819 The interplay between stiffness and hyperglycemia on diabetic foot ulcer wound closure

Albeltagy, N.; Patten, J.; Wang, K.

10.1101/2025.05.16.654387 — bioengineering — Posted on 2025-05-22

1820 EYE-Llama, an in-domain large language model for ophthalmology

haghighi, t.; Gholami, S.; Sokol, J. T.; Kishnani, E.; Ahsaniyan, A.; Rahmanian, H.; Hedayati, F.; Leng, T.; Alam, M. N.

10.1101/2024.04.26.591355 — bioengineering — Posted on 2025-05-22

1821 Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions.

Almeida, T.; Hargreaves, E.; Zech, T. N.; Barsukov, I.

10.1101/2024.02.27.581919 — biochemistry — Posted on 2025-05-22

1822 Natural selection shapes and regulates the population dynamics of birds and mammals

Witting, L.

10.1101/2021.11.27.470201 — ecology — Posted on 2025-05-22

1823 Alternatives to Friction Coefficient: Fine Touch Perception Correlates with Frictional Instabilities

Derkaloustian, M.; Bhattacharyya, P.; Ngo, T. T.; Cashaback, J.; Medina, J.; Dhong, C. B.

10.1101/2024.10.25.620351 — neuroscience — Posted on 2025-05-22

1824 Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions

Ediga, H. H.; Vemulapalli, C. P.; Sontake, V.; Patel, P. K.; Miyazaki, H.; Popov, D.; Jensen, M.; Jegga, A. G.; Huang, S. K.; Englert, C.; Schedl, A.; Gupta, N.; McCormack, F. X.; Madala, S. K.

10.1101/2025.05.17.654673 — pathology — Posted on 2025-05-22

1825 Stimulant medications affect arousal and reward, not attention

Kay, B. P.; Wheelock, M. D.; Siegel, J. S.; Raut, R.; Chauvin, R. J.; Metoki, A.; Rajesh, A.; Eck, A.; Pollaro, J.; Wang, A.; Suljic, V.; Adeyemo, B.; Baden, N. J.; Scheidter, K. M.; Monk, J.; Ramirez-Perez, N.; Krimmel, S. R.; Shinohara, R. T.; Tervo-Clemmens, B.; Hermosillo, R. J. M.; Nelson, S. M.; Hendrickson, T. J.; Madison, T.; Moore, L. A.; Miranda-Domlnguez, O.; Randolph, A.; Feczko, E.; Roland, J. L.; Nicol, G. E.; Laumann, T. O.; Marek, S. A.; Gordon, E. M.; Raichle, M. E.; Barch, D. M.; Fair, D. A.; Dosenbach, N. U. F.

10.1101/2025.05.19.654915 — neuroscience — Posted on 2025-05-22

1826 Exploring Spike-Dependent and ACE2-Independent Viral Entry into Salivary Epithelial Cells in the Absence of ACE2

Barrows, C. M. L.; Young, S.; Farach-Carson, M. C.

10.1101/2025.05.19.654917 — cell biology — Posted on 2025-05-22

1827 Temperature-dependent modulation of aberrant influenza A virus RNA synthesis affects innate immune signaling

Bisht, K.; Weilandt, D.; Lamb, C.; Elshina, E.; Myhrvold, C.; te Velthuis, A. J. W.

10.1101/2025.05.19.654939 — microbiology — Posted on 2025-05-22

1828 Navigating contradictions: Salmonella Typhimurium chemotaxis amidst conflicting stimuli of the intestinal environment

Franco, K. M.; Gentry-Lear, Z.; Shavlik, M.; Harms, M. J.; Baylink, A.

10.1101/2024.01.18.576330 — microbiology — Posted on 2025-05-22

1829 The effects of predator recovery and climate change on the long-term demography of a flagship herbivore

Loonam, K.; Brown, C.; Clark, D.; Rowland, M.; Wisdom, M.; Levi, T.

10.1101/2025.05.16.654556 — ecology — Posted on 2025-05-22

1830 Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis

Misra, A.; Weitman, E. M.; Weitman, M.; Brook, J. R.; Rone, J. M.; Petrova, B.; Mertens, R. T.; Hwang, N.; Zambrano Vera, K.; Perrella, M. A.; Baron, R. M.; Kanarek, N.; Nowarski, R.

10.1101/2025.05.22.654748 — pathology — Posted on 2025-05-22

1831 Conformal Bioprinting of Bi-phasic Jammed Bioinks, Independent of Gravity, Orientation, and Curvature

Singh, S.; Wei, L.; Samiei, E.; Gaber, K.; Gao, Q.; Persad, A.; Veres, T.; Guenther, A.

10.1101/2025.05.16.654553 — bioengineering — Posted on 2025-05-22

1832 Reconstitution of actomyosin networks in cell-sized liposomes reveals distinct mechanical roles of cytoskeletal organization in membrane shape remodeling

Miyazaki, M.; Laboni, F. S.; Kim, T.

10.1101/2025.05.18.654456 — biophysics — Posted on 2025-05-22

1833 Variation in responses to temperature across admixed genotypes of Populus trichocarpa x P. balsamifera predict geographic shifts in regions where hybrids are favored

Mead, A.; Beasley-Bennett, J. R.; Bleich, A. C.; Fischer, D. G.; Flint, S.; Golightly, J.; Klopf, S. K.; Kulbaba, M. W.; Lasky, J.; LeBoldus, J. M.; Lowry, D. B.; Mitchell, N.; Moran, E. V.; Sexton, J. P.; Sondreli, K. L.; Worthing, B. W.; Zavala-Paez, M.; Fitzpatrick, M. C.; Holliday, J. A.; Keller, S. R.; Hamilton, J. A.

10.1101/2025.05.16.654548 — evolutionary biology — Posted on 2025-05-22

1834 Mechanisms of Output Gating for visual working memory

Zhao, C.; Adekoya, T.; Horwitz, S.; Awh, E.; Vogel, E. K.

10.1101/2025.05.22.655454 — neuroscience — Posted on 2025-05-22

1835 The Modulation of the Blood-Brain Barrier by Focused Ultrasound Stimulates Oligodendrogenesis

Noseworthy, K. S.; Silburt, J.; Hynynen, K.; Aubert, I.

10.1101/2025.05.21.655298 — neuroscience — Posted on 2025-05-22

1836 SPONTANEOUS VISUAL IMAGERY DURING EXTENDED MUSIC LISTENING IS ASSOCIATED WITH RELIABLE ALPHA SUPPRESSION

Hashim, S.; Omigie, D.

10.1101/2025.05.18.654076 — neuroscience — Posted on 2025-05-22

1837 Dissecting Rate-Limiting Processes in Biomolecular Condensate Exchange Dynamics

Kliegman, R.; Kengmana, E.; Schulman, R.; Zhang, Y.

10.1101/2025.05.16.654578 — biophysics — Posted on 2025-05-22

1838 AttentionAML: An Attention-based Deep Learning Framework for Accurate Molecular Categorization of Acute Myeloid Leukemia

Li, L.; Khoury, J. D.; Wang, J.; Wan, S.

10.1101/2025.05.20.655179 — bioinformatics — Posted on 2025-05-22

1839 A complete reference genome assembly and annotation of the Black Redstart (Phoenicurus ochruros)

Ghimire, P.; Wang, N.; Lamichhaney, S.

10.1101/2025.05.21.655187 — genomics — Posted on 2025-05-22

1840 Deconstructing natural products to develop synthetic small molecule attachment inhibitors with broad spectrum antiviral activity

Correa-Sierra, C. C.; Cameron, J.; Hosseini, S. N.; Schatz, D.; Donnelly, J.; Murrell, C. M.; Mukhtarov, F.; Colpitts, C. C.; West, F.; Schang, L. M.

10.1101/2025.05.20.655152 — microbiology — Posted on 2025-05-22

1841 Enhanced anti-nociception by novel dual antagonists for 5HT2aR and mGluR5 in preclinical models of pain

Choi, D.; Heo, H. J.; Shin, H.; Im, J.; Lee, G.; Kim, A. H.; Hur, K.-H.; Nho, Y.; Jang, C.-G.; Lee, H.

10.1101/2025.05.21.655254 — neuroscience — Posted on 2025-05-22

1842 Brain State Convergence and Divergence as Resting State FMRI Biomarkers: A Large-Scale Study of Continuous, Overlapping, Time-resolved States Differentiates Four Psychiatric Disorders

Soleimani, N.; Wiafe, S.-L.; Iraji, A.; Pearlson, G. D.; Calhoun, V.

10.1101/2025.05.20.655164 — neuroscience — Posted on 2025-05-22

1843 Study buddy learning is associated with academic success in undergraduate science courses

Jones, A.; Reznik, G.; Hossain, A. R.; Dudarev, V.; Hui, B.; Belleville, P.; Williams, W.; Fussner-Dupas, E.; Enns, J. T.

10.1101/2025.05.20.655056 — scientific communication and education — Posted on 2025-05-22

1844 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Northwest Ethiopia

10.1101/2024.08.10.607441 — pathology — Posted on 2025-05-22

1845 High-Speed Multiplexed DNA-PAINT Imaging of Nuclear Organization Using an Expanded Sequence Repertoire

Banerjee, A.; Anand, M.; Srivastava, M.; Vidwath, V. S.; Ganji, M.

10.1101/2024.12.21.629871 — biophysics — Posted on 2025-05-22

1846 Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor

Shahriar, S.; Patel, T. D.; Nakka, M.; Grimm, S. L.; Coarfa, C.; Gorelick, D. A.

10.1101/2023.05.01.538985 — genomics — Posted on 2025-05-22

1847 Lineage Analysis and Molecular Characterization of Bergmann Glia-like Progenitors in the Postnatal Mouse Cerebellum using in vivo Electroporation and Spatial Transcriptomics

Suyama, K.; Adachi, T.; Isogai, E.; Hasegawa, I.; Mizuno, M.; Kaiyuan, J.; Nishitani, K.; Miyashita, S.; Owa, T.; Hoshino, M.

10.1101/2025.05.20.655231 — developmental biology — Posted on 2025-05-22

1848 Exploring the immune environment of glioblastoma through single-cell RNA sequencing in humanized mouse models

Takei, J.; Furudate, K.; Nagaoka-Kamata, Y.; Iwaloye, O.; Jepson, C. E.; Blucas, M. T.; Saito, K.; Welner, R. S.; Van Meir, E. G.; Kamata, M.; Osuka, S.

10.1101/2025.05.17.654526 — immunology — Posted on 2025-05-22

1849 Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease

Shakiba, S.; Haddadi, N.-S.; Afshari, K.; Lubov, J. E.; Raef, H. S.; Li, R.; Yildiz-Altay, U.; Daga, M.; Refat, M. A.; Kim, E.; Galindo de Laflin, J.; Akabane, A.; Romano, P.; Vongvirath, J.; Sherman, S.; MacDonald, E.; Strassner, J. P.; Zhang, L.; Leon, M.; Baer, C. E.; Dresser, K.; Liang, Y.; Whitley, J. B.; Skopelja-Gardner, S.; Harris, J. E.; Deng, A.; Vesely, M. D.; Rashighi, M.; Richmond, J. M.

10.1101/2024.01.05.574422 — immunology — Posted on 2025-05-22

1850 Semi-automatic Geometrical Reconstruction and Analysis of Filopodia Dynamics in 4D Two-Photon Microscopy Images

Brence, B.; Brummer, J.; Dercksen, V. J.; Ozel, M. N.; Kulkarni, A.; Wolterhoff, N.; Prohaska, S.; Hiesinger, P. R.; Baum, D.

10.1101/2025.05.20.654789 — neuroscience — Posted on 2025-05-22

1851 Face-, color-, and word-specific patches in the human orbitofrontal cortex

Liu, J.; Cohen, L.; Zhan, M.; Bartolomeo, P.

10.1101/2025.04.22.650059 — neuroscience — Posted on 2025-05-22

1852 The neural mechanisms of fast versus slow decision-making

Nashaat, M.; Oraby, H.; Krasniqi, F.; Goh-Sauerbier, S. T.; Bosc, M.; Koerner, S.; Karayel, S.; Kepecs, A.; Larkum, M.

10.1101/2024.08.22.608577 — neuroscience — Posted on 2025-05-22

1853 Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

Zhang, Z.; Wen, W.; Lin, H.; Hu, D.; Li, H.; Luo, J.

10.1101/2025.05.16.654531 — pharmacology and toxicology — Posted on 2025-05-22

1854 Targetable BIRC5 dependency in therapy-resistant TP53 mutated acute myeloid leukemia

Mamdouh, A. M.; Lim, F. Q.; Mi, Y.; Olesinski, E. A.; Chan, C. G. T.; Jasdanwala, S.; Lin, X. X.; Wang, Y.; Tan, J. Y. M.; Bhatia, K. S.; Sapozhnikova, V.; Wang, C.; Mahesh, A. N.; Tan, D. E. L.; Chitkara, N.; Mertins, P.; Hogdal, L.; Brown, B. D.; Haferlach, T.; Lobry, C.; Lindsley, C.; Puissant, A.; Ho, H. K.; Das, S.; Letai, A.; Kornblau, S. M.; Krönke, J.; Ayoub, E.; Itahana, K.; Andreeff, M.; Bhatt, S.

10.1101/2025.05.17.654633 — cancer biology — Posted on 2025-05-22

1855 BMI-1 Modulation and Trafficking During M Phase in Diffuse Intrinsic Pontine Glioma

Umaru, B.; Mishra, D.; Senthil Kumar, S.; Pang, H.-H.; Devine, B.; Khan, K.; Drissi, R.

10.1101/2025.05.16.654605 — cancer biology — Posted on 2025-05-22

1856 Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma

Barr, T.; Jennings, V. A.; Roundhill, E. A.; Baugh, R. T.; Yamrali, M.; Owston, H.; McGonagle, D.; Giannoudis, P. V.; Caplen, N. J.; Khan, J.; Bell, J. C.; Burchill, S. A.; Errington-Mais, F.; Cook, G. P.

10.1101/2025.05.16.654440 — cancer biology — Posted on 2025-05-22

1857 Unveiling KRAS Mutant Structures with AlphaFold 3: New Avenues for Targeted Cancer Therapy

Zhao, G.; Zhao, Y.

10.1101/2025.05.16.654380 — cancer biology — Posted on 2025-05-22

1858 cellSight: Characterizing dynamics of cells using single-cell RNA-sequencing

Chatterjee, R.; Gohel, C.; Shook, B. A.; Rahnavard, A.

10.1101/2025.05.16.654572 — bioinformatics — Posted on 2025-05-22

1859 Age-informed, attention-based weakly supervised learning for neuropathological image assessment

Li, S.; Malamut, M.; McKee, A.; Cherry, J.; Tian, L.

10.1101/2025.05.16.654510 — bioinformatics — Posted on 2025-05-22

1860 Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer

Ma, Q.; Wang, X.; Duan, M.; Su, P.-L.; Li, J.; Krull, J.; Jin, J.; Chen, H.; Sun, Y.; Wu, W.; He, K.; Carpenter, R.; Zhang, C.; Cao, S.; Xu, D.; Wang, G.; Li, L.; Xin, G.; Carbone, D. P.; Li, Z.

10.1101/2025.05.16.654579 — bioinformatics — Posted on 2025-05-22

1861 Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis

Deng, Y.; Ehiogu, B.; Luca, E.; Dabdoub, A.; Le Cao, K.-A.; Wells, C.; Nayagam, B.

10.1101/2025.05.16.654631 — bioinformatics — Posted on 2025-05-22

1862 Guided Co-clustering Transfer Across Unpaired and Paired Single-cell Multi-omics Data

Li, H.; Liu, Y.; ZENG, P.

10.1101/2025.05.16.654635 — bioinformatics — Posted on 2025-05-22

1863 Optimizing Oyster Breeding with Machine Learning and BigData for Superior Quality

Nayak, P.; Mishra, D. R.; Swain, R.; Sahoo, D.

10.1101/2025.05.16.654565 — bioinformatics — Posted on 2025-05-22

1864 Deciphering the comprehensive relationship between 5'UTR and 3'UTR sequences with deep learning

Suga, K.; Yamada, K.; Hamada, M.

10.1101/2025.05.17.654644 — bioinformatics — Posted on 2025-05-22

1865 Forward Engineering Organ Development and Cancer Therapeutics with Optogenetics

Mim, M. S.; Cini, S.; Frank, C.; Wang, Z.; Dowling, A.; Zartman, J. J.

10.1101/2025.05.16.653804 — bioengineering — Posted on 2025-05-22

1866 Resolution Tradeoffs in Modularity Clustering with Application to Single Cell RNA-seq

Leviyang, S.

10.1101/2025.05.20.655159 — bioinformatics — Posted on 2025-05-22

1867 THE LASSA VIRUS FUSION DOMAIN HAS STRUCTURAL PLASTICITY AND EXPLOITS BIS(MONOACYLGLYCERO)PHOSPHATE FOR FUSION

Pennington, H. N.; Arulmoly, K.; Mulvihill, Q. M.; Shin, S.; Im, W.; Lee, J.

10.1101/2025.05.20.655079 — biochemistry — Posted on 2025-05-22

1868 Tracking butterfly flight in the field from an unmanned aerial vehicle (UAV): a methodological proof of principle.

de Margerie, E.; Monmasson, K.

10.1101/2024.07.17.603869 — animal behavior and cognition — Posted on 2025-05-22

1869 PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After Injury

Menon, A. S.; Kumaran, M.; Beji, D. S.; Kesireddy, D. K.; Sahu, Y.; Manjunath, S.; Sanyal, K.; Konda, M.; Banerjee, S.; Venkatesh, I.

10.1101/2025.05.14.654166 — neuroscience — Posted on 2025-05-22

1870 Scaling, but not instruction tuning, increases large language models' alignment with language processing in the human brain

Gao, C.; Ma, Z.; Chen, J.; Li, P.; Huang, S.; Li, J.

10.1101/2024.08.15.608196 — neuroscience — Posted on 2025-05-22

1871 Cellular computing without bioengineering

Ahavi, P.; Hoang, A.; Meyer, P.; Berthier, S.; Fiorini, F.; Castelli, F.; Epaulard, O.; Le Gouellec, A.; Faulon, J.-L.

10.1101/2024.09.12.612674 — systems biology — Posted on 2025-05-22

1872 Comparing AI and Human Mentoring in Supporting Dental Student Well-being: A Mixed-Methods Study

Rath, A.

10.1101/2025.05.20.655059 — scientific communication and education — Posted on 2025-05-22

1873 Microbially-mediated halogenation and dehalogenation cycling of organohalides in the ocean

Zhou, N.; Li, Q.; Liang, Z.; Yu, K.; Zhang, C.; Wang, H.; Li, P.; He, Z.; Wang, S.

10.1101/2025.05.17.654656 — ecology — Posted on 2025-05-21

1874 Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes

Medina, J. M.; Iruzubieta, P.; Fernandez-Lopez, R.; Crespo, J.; de la Cruz, F.

10.1101/2025.05.03.652020 — microbiology — Posted on 2025-05-21

1875 A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity

D'Souza, L.; Young, J.; Coffman, H. M.; Petrow, E. P.; Bhattacharya, D.

10.1101/2025.02.28.640639 — immunology — Posted on 2025-05-21

1876 Primary auditory cortex is necessary for the acquisition and expression of categorical behavior

Krall, R. F.; Cassidy, R. M.; Ghimire, M.; Chambers, C. N.; Arnold, M. P.; Brougher, L. I.; Chen, J.; Deshmukh, R.; King, H. B.; Morford, H. J.; Wiemann, J. M.; Williamson, R. S.

10.1101/2024.02.02.578700 — neuroscience — Posted on 2025-05-21

1877 Estimating fMRI Timescale Maps

Riegner, G.; Davenport, S.; Voytek, B.; Schwartzman, A.

10.1101/2025.04.23.650300 — neuroscience — Posted on 2025-05-21

1878 Aligning Neural Population Patterns Facilitates Motor Learning Transfer

Zhang, X.; Song, Z.; Shen, X.; Chen, S.; Huang, Y.; Principe, J.; Wang, Y.

10.1101/2025.05.16.654614 — neuroscience — Posted on 2025-05-21

1879 PYEAST - Python Enabled Automated Strain Transformation

Madika, A.; Suri, A.; Purohit, A.; Van Raad, D.; Norman, M.; Hartley, C.; Loan, T. D.

10.1101/2025.05.19.655004 — synthetic biology — Posted on 2025-05-21

1880 Tumoral hypoxic extracellular vesicles foster a protective microenvironment in triple-negative breast cancer

Pachane, B. C.; Bottaro, P. H. T.; Machado, A. M.; Castro, C. A.; Guerra, G.; Gozzer, L. T.; Grigoli, M. M.; Zutiao, A. D.; Fuzer, A. M.; Cominetti, M. R.; Altei, W. F.; Selistre-de-Araujo, H. S.

10.1101/2024.11.01.621519 — cancer biology — Posted on 2025-05-21

1881 Measurement and prediction of unmixing-dependent spreading in spectral flow cytometry panels

Mage, P. L.; Konecny, A. J.; Mair, F.

10.1101/2025.04.17.649396 — bioinformatics — Posted on 2025-05-21

1882 A Comprehensive Evaluation of Self Attention for Detecting Regulatory Feature Interactions

Jabeen, S.; Ben-Hur, A.

10.1101/2024.08.23.609428 — bioinformatics — Posted on 2025-05-21

1883 Perturbing postural stability during treadmill walking with dysfunctional electrical stimulation

Miyata, T.; Izumi, N.; Kimura, K.; Yamaguchi, T.; Yamamoto, S.; Masani, K.

10.1101/2025.05.20.655058 — bioengineering — Posted on 2025-05-21

1884 Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation

Fodera, D. M.; Xu, E. Z.; Duarte-Cordon, C. A.; Wyss, M.; Fang, S.; Chen, X.; Oyen, M. L.; Rosado-Mendez, I.; Hall, T.; Vink, J.; Feltovich, H.; Myers, K. M.

10.1101/2024.11.17.624020 — bioengineering — Posted on 2025-05-21

1885 Quantitative Fluorescence Imaging of Porphyrin Phospholipid Photobleaching and Light Activated Liposomal Doxorubicin Release Using Wide-field and Laparoscopic SFDI in an Ovarian Cancer Model

Ahmmed, R.; Kluiszo, E.; Aygun-Sunar, S.; Willadsen, M.; Kutscher, H. L.; Lovell, J.; Sunar, U.

10.1101/2025.02.14.638180 — bioengineering — Posted on 2025-05-21

1886 Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

Jing, T.; Shan, Z.; Dinh, T.; Biswas, A.; Jang, S.; Greenwood, J.; Li, M.; Zhang, Z.; Gray, G.; Shin, H. J.; Zhou, B.; Passos, D.; Strutzenberg, T. S.; Aiyer, S.; Andrade, L.; Li, Z.; Craigie, R.; Engelman, A. N.; Kvaratskhelia, M.; Lyumkis, D.

10.1101/2024.01.26.577436 — biochemistry — Posted on 2025-05-21

1887 Phylogenetic relationships of ATM polymorphic loci haplotypes in Eurasian and African populations

Olkova, M.; Koshel, S.; Ponomarev, G.; Alimov, A.

10.1101/2025.05.10.652950 — evolutionary biology — Posted on 2025-05-21

1888 Multivariate Trait Evolution: Models for the Evolution of the Quantitative Genetic G-Matrix on Phylogenies.

Blomberg, S. P.; Muniz, M.; Bui, M. N.; Janke, C.

10.1101/2024.10.26.620394 — evolutionary biology — Posted on 2025-05-21

1889 Modeling the acutely injured brain environment in vitro.

Maria Arzate, D.; Alvaro, V.; Pradanos-Senen, A. V.; Gallego, L.; Manzano-Franco, D.; Llorente-Saez, C.; Bartolome-Cabrero, R.; Ferrarini, A.; Lopez, J. A.; Murenu, E.; Berninger, B.; Ortega, F.; Goetz, M.; Heinrich, C.; Gascon, S.

10.1101/2025.01.08.631921 — neuroscience — Posted on 2025-05-21

1890 TrueSpot: A robust automated tool for quantifying signal puncta in fluorescent imaging

Hospelhorn, B. G.; Kesler, B. K.; Jashnsaz, H.; Neuert, G.

10.1101/2025.01.10.632467 — systems biology — Posted on 2025-05-21

1891 Translational buffering tunes gene expression in mouse and human

Rao, S.; Le, A. Y.; Persyn, L.; Cenik, C.

10.1101/2025.05.16.654561 — bioinformatics — Posted on 2025-05-21

1892 Change point based dynamic functional connectivity estimation outperforms sliding window and static estimation for classification of early mild cognitive impairment in resting-state fMRI

Ondrus, M.; Cribben, I.

10.1101/2025.05.16.654552 — bioinformatics — Posted on 2025-05-21

1893 Local negative frequency-dependence can decrease global coexistence in fragmented populations

Devadhasan, A.; Carja, O.

10.1101/2025.05.19.654891 — evolutionary biology — Posted on 2025-05-21

1894 The recombination landscape of Drosophila melanogaster can be repatterned by a single gene

Hughes, S. E.; Staber, C.; McKown, G.; Yu, Z.; Blumenstiel, J. P.; Hawley, R. S.

10.1101/2025.05.16.654569 — genetics — Posted on 2025-05-21

1895 Microbiome-mediated resilience and cross-generational consequences in male Drosophila exposed to combined environmental stressors

Maggu, K.; Meena, A.; De Nardo, A. N.; Eggs, B.; Sbilordo, S. H.; Al Tom Sho, R.; Lupold, S.

10.1101/2025.05.16.654542 — ecology — Posted on 2025-05-21

1896 Unveiling differential responses to UVB (305 nm) and UVC (275 nm) in cacao-infecting Colletotrichum gloeosporioides and Pestalotiopsis sp.

Baek, I.; Jang, J. H.; Lim, S.; WANG, Z.; Cha, M.; Magill, C.; Kim, M. S.; Meinhardt, L.; Park, S.; Ahn, E.

10.1101/2025.05.21.655292 — microbiology — Posted on 2025-05-21

1897 Intralysosomal pathogens differentially influence the proteolytic potential of their niche

Bird, L. E.; Xu, B.; McGowan, E. N. S.; Newton, P.; Scott, N. E.; McConville, M. J.; Edgington-Mitchell, L.; Newton, H. J.

10.1101/2025.05.21.655381 — microbiology — Posted on 2025-05-21

1898 Hepatitis C virus NS3/4A protease cleaves SPG20, a key regulator of lipid droplet turnover, to promote lipid droplet formation

Matsui, C.; Yuliandari, P.; Deng, L.; Abe, T.; Shoji, I.

10.1101/2025.05.21.655255 — microbiology — Posted on 2025-05-21

1899 A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival

Chen, L.; Duan, B.; Chen, P.; Jiang, Q.; Wang, Y.; Lu, L.; Chen, Y.; Hu, C.; Zhang, L.; Guo, A.

10.1101/2025.05.21.655295 — microbiology — Posted on 2025-05-21

1900 Fragment Screening by Weak Affinity Chromatography Identifies Ligands for Neisseria gonorrhoeae Undecaprenyl Diphosphate Synthase

Santiago, A. d. S.; Amaral, B. S.; Llontopp, E.; Ramos, P. Z.; Souza, L. R.; Cunha, M. R.; Piccirillo, E.; Almeida, V. M.; Pilli, R. A.; Barreiro, G.; Massirer, K. B.; Counago, R. M.

10.1101/2025.05.21.654962 — microbiology — Posted on 2025-05-21

1901 Long-term Reprogramming and Altered Ontogeny of Classical Monocytes Mediates Enhanced Lung Injury in Sepsis Survivor Mice

Denstaedt, S. J.; McBean, B.; Boyle, A. P.; Arenberg, B. C.; Mack, M.; Moore, B. B.; Newstead, M. W.; Singer, B. H.; Cano, J.; Prescott, H. C.; Goodridge, H. S.; Zemans, R. L.

10.1101/2025.05.16.654442 — immunology — Posted on 2025-05-21

1902 Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease

Zhang, L.; Yasumizu, Y.; Deerhake, M. E.; Moon, J.; Buitrago-Pocasangre, N.; Russo, A.; Wang, H.; Zhu, B.; Seibyl, J. P.; Reddy, V.; Wang, Q.; Spillantini, M. G.; Posner, D. A.; Clatworthy, M.; Sumida, T. S.; Longbrake, E. E.; Cedarbaum, J. M.; Hafler, D. A.

10.1101/2025.05.16.654530 — immunology — Posted on 2025-05-21

1903 Integration of strain and process optimization to increase autotrophic growth of engineered Komagataella phaffii

Baumschabl, M.; Lutz, L.; Jecmenica, M.; Ata, O.; Mattanovich, D.

10.1101/2025.05.21.655372 — synthetic biology — Posted on 2025-05-21

1904 Comparison of QuPath and HALO platforms for analysis of the tumor microenvironment in prostate cancer

zhang, w.; Zhou, Q.; Nguyen, J. V.; Egal, E.; Yang, Q.; Freeman, M. R.; Hu-Lieskovan, S.; Suneja, G.; Coghill, A.; Knudsen, B. S.

10.1101/2025.05.16.654590 — pathology — Posted on 2025-05-21

1905 The Splicing Factor PTBP1 interacts with RUNX1 and is Required for Leukemia Cell Survival

Dhir, A.; Ethell, A.; Watkins, R.; Lam, C.; Tur-Rodriguez, K.; Persinger, J.; Dobish, K. K.; Panda, S.; Buckley, S. M.; Swenson, S. A.; Brahma, S.; Rowley, M. J.; Hyde, R. K.

10.1101/2025.05.16.654547 — cancer biology — Posted on 2025-05-21

1906 Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI

Chang, K.; Serasanambati, M.; Ogunlade, B.; Hsu, H.-J.; Agolia, J. P.; Stiber, A.; Gu, J.; Sharma, S.; Chadokiya, J.; Goncalves, A.; Safir, F.; Vu, N.; Delitto, D. J.; Kirane, A. R.; Dionne, J. A.

10.1101/2025.05.16.654612 — cancer biology — Posted on 2025-05-21

1907 EGR1 drives sex-differences in glioblastoma tumorigenicity

Abou-Antoun, T.; Llaci, L.; Wong, J. P.; Yang, L.; Warrington, N. M.; Tripp, L.; Luo, J.; Muegge, B.; Rubin, J. B.; Mitra, R. D.

10.1101/2025.05.16.654616 — cancer biology — Posted on 2025-05-21

1908 Optimizing effective labeling efficiency in MINFLUX 3D DNA-PAINT microscopy by maximizing marker detection probability.

Soeller, C.; Bokhobza, A. F. E.; Casares-Arias, J.; Clowsley, A. H.

10.1101/2025.05.16.654501 — biophysics — Posted on 2025-05-21

1909 Prediction of αIIbβ3 integrin structures along its minimum free energy activation pathway

Dasetty, S.; Coffman, R. E.; Bidone, T. C.; Ferguson, A. L.

10.1101/2025.05.16.654557 — biophysics — Posted on 2025-05-21

1910 Mechanism-driven screening of membrane-targeting and pore-forming antimicrobial peptides

Li, J.; Yang, C.; Dong, R.; Bada Juarez, J. F.; Wang, L.; Wettstein, M. E.; Wang, D.; Cao, C.; Lu, Y.; Song, C.

10.1101/2025.05.17.654650 — biophysics — Posted on 2025-05-21

1911 RNA structural complexity dictates its ion atmosphere

MAITY, H.; Zhang, P.; Thirumalai, D.; Nguyen, H. T.

10.1101/2025.05.19.654961 — biophysics — Posted on 2025-05-21

1912 ChromMovie: A Molecular Dynamics Approach for Simultaneous Modeling of Chromatin Conformation Changes from Multiple Single-Cell Hi-C Maps

Banecki, K. H.; Chai, H.; Ruan, Y.; Plewczynski, D.

10.1101/2025.05.16.654550 — bioinformatics — Posted on 2025-05-21

1913 Accounting for uncertainty in residual variances improves calibration of the Sum of Single Effects model for small sample sizes

Denault, W. R. P.; Carbonetto, P.; Li, R.; Consortium, T. A. s. D. F. G.; Wang, G.; Stephens, M.

10.1101/2025.05.16.654543 — bioinformatics — Posted on 2025-05-21

1914 Role of glutamate 292 and lysine 331 in catalysis for the flavoenzyme (S)-6-hydroxynicotine oxidase from Shinella sp. HZN7

Zhang, Z.; Freeland, K.; Stull, F.

10.1101/2025.05.21.655333 — biochemistry — Posted on 2025-05-21

1915 Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase

Pang, E. Z.; Zhao, B.; Flowers, C.; Oroudjeva, E.; Winter, J. B.; Pandey, V.; Sawaya, M. R.; Wohlschlegel, J.; Loo, J. A.; Rodriguez, J. A.; Clarke, S. G.

10.1101/2025.05.21.654933 — biochemistry — Posted on 2025-05-21

1916 Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection

Shaw, S.; Li, X.; Buenconsejo, G. Y.; Tiffany, Z. H.; Cohen, A.; Yasur, D.; Xiao, R.; Beiting, D. P.; Anderson, T. J.; Striepen, B.

10.1101/2025.05.20.655157 — genetics — Posted on 2025-05-21

1917 FimX regulates type IV pilus localization via the Pil-Chp chemosensory system in Acinetobacter baylyi

Ellison, T. J.; Yen, I. Y.; Howell, P. L.; Ellison, C. K.

10.1101/2025.05.21.655318 — microbiology — Posted on 2025-05-21

1918 Contrasting temporal patterns and associations in Hyalomma marginatum microbial communities: key insights for the development of novel tick and tick-borne diseases control tools

JOLY-KUKLA, C.; Manzanilla, V.; Duhayon, M.; Bru, D.; Jeanneau, M.; Moutailler, S.; Pollet, T.

10.1101/2025.05.21.655249 — microbiology — Posted on 2025-05-21

1919 Multiple-omics analyses of the Alviniconcha holobiont reveal multi-faceted adaptations to deep-sea hydrothermal vents

Wang, H.; Dai, Y.; Chen, C.; He, X.; Li, M.; Zhou, Y.; Ip, J. C.-H.; Sun, J.

10.1101/2025.05.21.655246 — microbiology — Posted on 2025-05-21

1920 BIO-SPEC: an open-source bench-top parallel bioreactor system.

Parret, L.; Simoens, K.; De Vrieze, J.; Smets, I.

10.1101/2025.05.21.655256 — microbiology — Posted on 2025-05-21

1921 Arp2/3 complex contributes to the actin-dependent uptake of Aspergillus terreus conidia by alveolar epithelial cells

Mach, N.; Polleux, J.; Heinrich, L.; Lechner, L.; Levytska, I.; Lass-Floerl, C.; Perkhofer, S.

10.1101/2025.05.21.655299 — microbiology — Posted on 2025-05-21

1922 Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics

Ayyar, B. V.; Apostol, C. V.; Dave, J.; Kaundal, S.; Neill, F. H.; Ettayebi, K.; Maher, S.; Anish, R.; Larson, G.; Atmar, R. L.; Crawford, S. E.; Prasad, B. V. V.; Estes, M. K.

10.1101/2025.05.20.655000 — microbiology — Posted on 2025-05-21

1923 The tiniest genomes shrink much further: extreme reductive evolution in planthopper symbionts

Michalik, A.; Castillo Franco, D.; Deng, J.; Prus-Frankowska, M.; Stroinski, A.; Lukasik, P.

10.1101/2025.05.16.654412 — evolutionary biology — Posted on 2025-05-21

1924 Resource diversity and supply drive colonization resistance

Rappaport, E.; Mirollo, R.; Momeni, B.

10.1101/2025.05.16.654587 — ecology — Posted on 2025-05-21

1925 Long-Term Ecological Baselines and Critical Thresholds in Ombrotrophic Peatlands of Europe: Implications for Restoration Strategies

Draga, M.; Gałka, M.; Knorr, K.-H.; Glatzel, S.; Chojnicki, B.; Fritz, C.; Jassey, V.; Juszczak, R.; Meyer, H.; Robroek, B.; Thomas, C.; Lamentowicz, M.

10.1101/2025.05.16.654541 — ecology — Posted on 2025-05-21

1926 Shared Hierarchical Representations Explain Temporal Correspondence Between Brain Activity and Deep Neural Networks

Lutzow Holm, E.; Marrafini, G.; Fernandez Slezak, D.; Tagliazucchi, E.

10.1101/2025.05.19.655003 — neuroscience — Posted on 2025-05-21

1927 Seizure Circuit Activity in the Theilers Murine Encephalomyelitis Virus Model of Infection-induced Epilepsy Using Transient Recombination in Active Populations.

Petrucci, A. N.; Abel, T. N.; Wilcox, K. S.

10.1101/2025.05.20.655185 — neuroscience — Posted on 2025-05-21

1928 Disturbed engram network caused by NPTXs downregulation underlies aging-related memory deficits

Jin, T.; Yang, Y.; Guo, Y.; Zhang, Y.; Le, Q.; Huang, N.; Liu, X.; Yu, J.; Ma, L.; Wang, F.

10.1101/2025.05.19.654996 — neuroscience — Posted on 2025-05-21

1929 Two senses, one rhythm: Pre- and post-stimulus neural states predict perceived audio-visual synchrony

Talwar, S.; Barbero, F. M.; van Ackeren, M. J.; Weisz, N.; Collignon, O.

10.1101/2025.05.20.655148 — neuroscience — Posted on 2025-05-21

1930 Proximate Composition and Mineral Analysis of Housefly Maggots and Mealworms Compared to Fish and Soybean Meals

Nayab, G. e.; Rashid, S. B.; Khan, S.; Sultan, A.; Khan, I.; Khan, R.

10.1101/2025.05.18.654638 — zoology — Posted on 2025-05-21

1931 Ventral Hippocampus and NAc Core, but not Shell activity is required for well-learned instrumental memory destabilization

Hypolito Lima, R.; Cheng, C.; Lee, J.

10.1101/2025.05.21.654887 — animal behavior and cognition — Posted on 2025-05-21

1932 Heavy Metal Exposure Disrupts Electrotactic Behavior in Caenorhabditis elegans

Taylor, S. K. B.; Minhas, M. H.; Tong, J.; Selvaganapathy, P. R.; Mishra, R. K.; Gupta, B. P.

10.1101/2025.05.20.655158 — animal behavior and cognition — Posted on 2025-05-21

1933 Chimpanzee and human ApoE isoforms differ in the stimulation of neurite differentiation consistent with structural predictions with relevance to brain development and aging

Thorwald, M. A.; Cacciottolo, M.; Hou, X.; Morgan, T. E.; Finch, C. E.

10.1101/2025.05.21.655373 — neuroscience — Posted on 2025-05-21

1934 The Human Insula Encodes Somatotopic Representation of Motor Execution with an Effector-Specific Connectomic Map to Primary Motor Cortex

Kerezoudis, P.; Jensen, M. A.; Klassen, B. T.; Worrell, G. A.; Gregg, N. M.; Ince, N. F.; Hermes, D.; Miller, K. J.

10.1101/2025.05.19.653527 — neuroscience — Posted on 2025-05-21

1935 Brain Multi-Omic Subtypes of Neuroticism Reveal Molecular Signatures linked to Alzheimer's Disease

Zammit, A. R.; Lopes, K. d. P.; Batalha, C. M. P. F.; Yu, L.; Poole, V. N.; Tasaki, S.; Kapasi, A.; Wang, Y.; De Jager, P. L.; Menon, V.; Seyfried, N.; Kaddurah-Daouk, R.; Iturria-Medina, Y.; Bennett, D. A.

10.1101/2025.05.19.654904 — neuroscience — Posted on 2025-05-21

1936 Intercellular communication in the brain via dendritic nanotubular network

Chang, M.; Kruessel, S.; Parajuli, L. K.; Kim, J.; Lee, D.; Merodio, A.; Kwon, J.; Okabe, S.; Kwon, H.

10.1101/2025.05.20.655147 — neuroscience — Posted on 2025-05-21

1937 Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Butler, P. M.; Francis, A.; Meunier, A. L.; Anderson, A. K.; Hennessey, E. L.; Miller, M. B.; Lemere, C. A.; Selkoe, D. J.; Stern, A. M.

10.1101/2025.05.20.654902 — neuroscience — Posted on 2025-05-21

1938 Accelerating Neuron Reconstruction with PATHFINDER

Januszewski, M.; Templier, T.; Hayworth, K. J.; Peale, D.; Hess, H.

10.1101/2025.05.16.654254 — neuroscience — Posted on 2025-05-21

1939 Purkinje Cell spike patterns do not correlate with nuclei cell spike patterns in mouse models for cerebellar disease

Lyon, A. M.; van der Heijden, M. E.

10.1101/2025.05.19.654856 — neuroscience — Posted on 2025-05-21

1940 Development of noninvasive imaging to measure spontaneous pain in mice

Yuan, S.; Liew, J. Y.; Pal, A.; Wang, J.; Green, D. P.; Motamedi, M.; Tang, S.-J.

10.1101/2025.05.20.655170 — neuroscience — Posted on 2025-05-21

1941 Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

Shevtsova, N. A.; Lockhart, A. B.; Rybak, I. A.; Magnuson, D. S.; Danner, S. M.

10.1101/2025.05.17.654682 — neuroscience — Posted on 2025-05-21

1942 Error-driven changes in hippocampal representations accompany flexible re-learning

Rich, P. D.; Thiberge, S. Y.; Daw, N. D.; Tank, D. W.

10.1101/2025.05.20.655046 — neuroscience — Posted on 2025-05-21

1943 Large Scale Cell Painting Guided Compound Selection Reveals Activity Cliffs and Functional Relationships

Sanchez, M.; Bourriez, N.; Bendidi, I.; Cohen, E.; Svatko, I.; Del Nery, E.; Tajmouati, H.; Bollot, G.; Calzone, L.; Genovesio, A.

10.1101/2025.05.16.654292 — bioinformatics — Posted on 2025-05-21

1944 Monkeys integrate facial expressions and direct gaze to modulate gaze-following behavior

Chong, I.; Thier, P.

10.1101/2025.05.18.654731 — animal behavior and cognition — Posted on 2025-05-21

1945 Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity

Domen, J.; Voskoboynik, Y.; Levy, T.; Domen, E. M.; Ishizuka, K. j.; Palmeri, K. j.; Anselmi, C.; Rolander, T.; Neff, N. F.; Detweiler, A. M.; Weissman, I. L.; Gandy, K. L.; Sahoo, D.; Voskoboynik, A.

10.1101/2025.05.17.654683 — developmental biology — Posted on 2025-05-21

1946 Enrichment of neural crest cells by antibody labelling and flow cytometry for single-cell transcriptomics in a lizard

Pranter, R.; Patthey, C.; Feiner, N.

10.1101/2025.05.21.655068 — developmental biology — Posted on 2025-05-21

1947 Dissociable Pupil and Oculomotor Markers of Attention Allocation and Distractor Suppression during listening

Liu, X.; Chait, M.

10.1101/2025.05.19.654866 — neuroscience — Posted on 2025-05-21

1948 The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury

Laabei, J.; Vegliante, G.; Strogulski, N. R.; Douglas, C.; Threja, S.; Pearson, A.; Nkiliza, A.; Hanscom, M.; Filogonio Emediato, I. D.; Crawford, F.; Ojo, J.; Loane, D.

10.1101/2025.05.16.654460 — neuroscience — Posted on 2025-05-21

1949 Introductory notes before zebra finch song have unique timing properties while sharing acoustic properties with song

Rao, D.; Rajan, R.

10.1101/2025.05.19.654952 — neuroscience — Posted on 2025-05-21

1950 Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide

Malange, K.; Lemes, J. B. P.; Noble, B.; Anchondo, Y.; Urbina, C. M.; Jadhav, S.; Dochnal, S. A.; Kambalimath, C.; Alvarez, P.; Fitzsimmons, B.; Mazur, C.; Kordasiewicz, H.; Dore, K.; Zhao, H.; Yaksh, T. L.

10.1101/2025.05.19.654680 — neuroscience — Posted on 2025-05-21

1951 Glutamatergic Dysfunction of Astrocytes in Paraventricular Nucleus of Thalamus Contributes to Adult Anxiety Susceptibility in Adolescent Ethanol Exposed Mice

Bennett, A.; Kim, H.; Thomas, D.; Biggs, P.; Ara, R.; Bosomtwi, A.; Kang, S.

10.1101/2025.05.20.654912 — neuroscience — Posted on 2025-05-21

1952 NaviGraph

Koren Iton, A.; Iton, E.; Michaelson, D. M.; Blinder, P.

10.1101/2025.05.18.654725 — neuroscience — Posted on 2025-05-21

1953 Increased vulnerability to noise exposure of low spontaneous rate type 1C spiral ganglion neuron synapses with inner hair cells (Pre-Print)

Reijntjes, D. O. J.; Burke, K.; Paul, S.; Mueller, U.; Glowatzki, E.; Lauer, A. M.

10.1101/2025.05.19.654865 — neuroscience — Posted on 2025-05-21

1954 The semantics of dreams

Elce, V.; Bontempi, G.; Scarpelli, S.; Pedreschi, B.; De Gennaro, L.; Pietrini, P.; Bellesi, M.; Bernardi, G.; Handjaras, G.

10.1101/2025.05.20.654459 — neuroscience — Posted on 2025-05-21

1955 Endotoxemia-induced inflammation in the absence of obesity decreases anxiety-like and impulsive behavior without affecting learning and memory

Klug, M. E.; Crain, E.; Hayes, A. M. R.; Shanmugam, M.; de La Serre, C.; Kanoski, S. E.

10.1101/2025.05.19.654970 — neuroscience — Posted on 2025-05-21

1956 CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures

Porkhodadad, S.; Wang, W.; Dingledine, R.; Varvel, N.

10.1101/2025.05.19.655010 — neuroscience — Posted on 2025-05-21

1957 Rapid FFR: A rapid method for obtaining Frequency Following Responses

Huber, J.; Rosen, S.; Schoof, T.; Stewart, H.; de Cheveigne, A.

10.1101/2025.05.20.655073 — neuroscience — Posted on 2025-05-21

1958 Spatial distance and temporal attentional focus modulate voluntary action preparation and awareness

Kong, G.; Barlerin, B.; Desoche, C.; Miller, L.; Pavani, F.; Farne, A.; Vernet, M.

10.1101/2025.05.20.654810 — neuroscience — Posted on 2025-05-21

1959 Cell type distribution of intrathecal antisense oligonucleotide activity in deep brain regions of non-human primates

Frei, J.; Gentile, J.; Lian, Y.; Mortberg, M. A.; Capitanio, J.; Jafar-nejad, P.; Vallabh, S. M.; Zhao, H. T.; Minikel, E. V.

10.1101/2025.05.20.655163 — neuroscience — Posted on 2025-05-21

1960 A hierarchy of time constants and reliable signal propagation in the marmoset cortex

Li, G.; Li, S.; Wang, X.-J.

10.1101/2025.05.18.654729 — neuroscience — Posted on 2025-05-21

1961 Enkephalinergic Neurons Gate Sex-Specific Control of Voluntary Micturition

Klymko, N.; Sartori, A. M.; Leon, M.; Seifert, C. N.; Lee, R.; Mathai, J. C.; Verstegen, A. M. J.

10.1101/2025.05.16.654570 — neuroscience — Posted on 2025-05-21

1962 A tale of two birds: cognitive simplicity drives collective route improvements in homing pigeons

Banerjee, S. C.; Francisco, F. A.; Kao, A. B.

10.1101/2025.05.16.654518 — animal behavior and cognition — Posted on 2025-05-21

1963 Tissue resident macrophages innately develop in a human iPSC-derived cardiac organoid model

Rockel, A. F.; Brunnbauer, T.; Wagner, N.; Gerull, B.; Erguen, S.; Woersdoerfer, P.

10.1101/2025.05.20.654824 — developmental biology — Posted on 2025-05-21

1964 Chinmo defines the region-specific oncogenic competence in the Drosophila central nervous system

Nguyen, P.-K.; Froldi, F.; Cheng, L.

10.1101/2025.05.20.655209 — developmental biology — Posted on 2025-05-21

1965 Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair

Chu, C.-W.; Velayudhan, S. S.; Schauser, J. H.; Krishnakumar, S.; Yang, S.; Itoh, K.; Alfandari, D.; Trusina, A.; Sokol, S. Y.

10.1101/2025.05.20.654909 — developmental biology — Posted on 2025-05-21

1966 Decoding the molecular logic of rapidly evolving ZAD zinc-finger proteins in Drosophila

Saito, R.; Umemura, Y.; Makino, S.; Fukaya, T.

10.1101/2025.05.21.655257 — molecular biology — Posted on 2025-05-21

1967 Interplay of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans along with Circulating miR-21 and miR-155 as Potential Biomarkers for Pancreatic Cancer

Hesami, Z.; Olfatifar, M.; Sadeghi, A.; Mohammadi-Yeganeh, S.; Eghlimi, H.; Pazienza, V.; Hakemi-Vala, M.; Houri, H.

10.1101/2025.05.21.655259 — molecular biology — Posted on 2025-05-21

1968 TRiC-assisted folding of class I HDAC family proteins regulated by distinct co-chaperone and cofactor networks

li, z.; Zhao, Q.; jiang, w.; song, q.; zhou, x.; shi, x.; zhang, q.; wang, y.; lin, y.; Yin, Y.; pan, c.; Cong, Y.

10.1101/2025.05.21.655272 — molecular biology — Posted on 2025-05-21

1969 3D organoids containing endothelial and neural cells generation by serial inductions of differentiation on human iPSC-derived embryoid bodies

Wang, T.; Bagnell, A.; McDonald, V.; Gastfriend, B. D.; Steiner, J. P.; Elkahloun, A. G.; Johnson, K.; Langston, R. G.; Cookson, M. R.; Nath, A.

10.1101/2025.05.20.653559 — neuroscience — Posted on 2025-05-21

1970 Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults

Fischer, L.; Adams, J. N.; Molloy, E. N.; Tremblay-Mercier, J.; Remz, J.; Pichet Binette, A.; Rajah, M. N.; Villeneuve, S.; Maass, A.; PREVENT-AD Research Group,

10.1101/2025.05.16.654628 — neuroscience — Posted on 2025-05-21

1971 Exploring the association between walking, sleep patterns, brain perivascular spaces, and cognitive function in Parkinson's disease

Sibilia, F.; Barisano, G.; Fotouhi, M.; Loehrer, P. A.; Wong, K.; Mack, W. J.; Lew, M.; Dafsari, H.; Choupan, J. A.

10.1101/2025.05.16.654573 — neuroscience — Posted on 2025-05-21

1972 Stabilization of recurrent neural networks through divisive normalization

Morone, F.; Rawat, S.; Heeger, D. J.; Martiniani, S.

10.1101/2025.05.16.654567 — neuroscience — Posted on 2025-05-21

1973 Shared and distinct cortical mechanisms for working memory and decision-making.

Seo, H.; Lee, D.; Murray, S. K.

10.1101/2025.05.21.655340 — neuroscience — Posted on 2025-05-21

1974 Intersecting effects of social circumstances and transcendent thinking on mid-adolescents' longitudinal functional connectome development

Ghaderi, A. H.; Yang, X.-F.; Gotlieb, R.; Johnson, D. L.; Immordino-Yang, M. H.

10.1101/2025.05.20.654735 — neuroscience — Posted on 2025-05-21

1975 A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

Calle-Schuler, S. A.; Santana-Cruz, A. E.; Kmecova, L.; Hampel, S.; Seeds, A. M.

10.1101/2025.05.19.654894 — neuroscience — Posted on 2025-05-21

1976 Frequency-dependent diffusion tensor distribution imaging in the evaluation of ischemic stroke

Grohn, S.; Naranjo, A.; Narvaez, O.; Yon, M.; Buz-Yalug, B.; Blanco, S.; Topgaard, D.; Martinez-Lara, E.; Peinado, M. A.; Tohka, J.; Sierra, A.

10.1101/2025.05.19.654809 — neuroscience — Posted on 2025-05-21

1977 Absence of testes at puberty impacts functional development of nigrostriatal but not mesoaccumbal dopamine terminals in a wild-derived mouse

Mun, J.; Jackson, S. C.; Prounis, G.; Phumsatitpong, C.; Motahari, N.; Kriegsfeld, L.; Landry, M. P.; Wilbrecht, L.

10.1101/2025.05.16.654596 — neuroscience — Posted on 2025-05-21

1978 Sound offset responses become highly informative in the auditory cortex

Lamothe, C.; Bagur, S.; Gosselin, E.; Bathellier, B.

10.1101/2025.05.19.654889 — neuroscience — Posted on 2025-05-21

1979 Youth-associated protein TIMP2 alters microglial state and function in the context of aging

Hemmer, B. M.; Ferreira, A. C.; Philippi, S. M.; Petridis, S. F.; Phan, A.; Castellano, J. M.

10.1101/2025.05.20.655226 — neuroscience — Posted on 2025-05-21

1980 Age as a moderator variable in the investigation of the relationship between brain structure and cognition

Griffin, B.; Gohil, C.; Woolrich, M. W.; Smith, S.; Vidaurre, D.

10.1101/2025.05.19.654872 — neuroscience — Posted on 2025-05-21

1981 DJ-1 deficiency and aging: dual drivers of retinal mitochondrial dysfunction.

Upadhyay, M.; Sturgis, J.; Bhattacharyya, S.; Jiang, K.; Hagstrom, S. A.; Bonilha, V. L.

10.1101/2025.05.19.654941 — neuroscience — Posted on 2025-05-21

1982 The anterior olfactory nucleus mediates curious exploration evoked by novel odors

De Plus, R.; Martijn, B.; Giaffar, H.; Eleonore, S.; Kondrakiewicz, K.; Aydin, C.; Haesler, S.

10.1101/2025.05.19.654779 — neuroscience — Posted on 2025-05-21

1983 Perivascular space mediated the interaction between sleep, and brain functional connectivity in the healthy aging population

Shih, N.-C.; Contreras, J.; Mack, W. J.; Choupan, J.

10.1101/2025.05.19.654921 — neuroscience — Posted on 2025-05-21

1984 Neural mechanisms for visuomotor co-regulation in social synchronization

Uccelli, S.; Sacheli, L. M.; De Bernardi, C.; Devoto, F.; Basso, G.; Paulesu, E.

10.1101/2025.05.21.655276 — neuroscience — Posted on 2025-05-21

1985 Assessing the robustness of deep learning based brain age prediction models across multiple EEG datasets

Tveitstoel, T.; Tveter, M.; Hatlestad-Hall, C.; Hammer, H. L.; Engemann, D.; Haraldsen, I.

10.1101/2025.05.20.655022 — neuroscience — Posted on 2025-05-21

1986 Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition

Fabrizio-Stover, E. M.; Dias, J. W.; McClaskey, C. M.; Harris, K. C.

10.1101/2025.05.19.654964 — neuroscience — Posted on 2025-05-21

1987 Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses

Clarke, D.; Bosson, A.; Honore, E.; Contant, K.; Avignone, E.; Lacaille, J.-C.; Robitaille, R.

10.1101/2025.05.16.654545 — neuroscience — Posted on 2025-05-21

1988 Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Paz, R. M.; Ryan, M. B.; Marcott, P. F.; Girasole, A. E.; Faryean, J.; Duong, V.; Sridhar, S.; Nelson, A. B.

10.1101/2025.05.16.654598 — neuroscience — Posted on 2025-05-21

1989 Inhibitory Circuit Compensations in Female and Male Mice: Increased Synaptic Output Offsets Reduced Parvalbumin Interneuron Density

Khiabanian, N. K.; Terstege, D. J.; Ahn, B. Y.; Xu, S. C.; Seo, H.; Sargin, D.; Epp, J. R.

10.1101/2025.05.20.655207 — neuroscience — Posted on 2025-05-21

1990 Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation

Kriukov, E.; Mukwaya, A.; Cullen, P. F.; Baldwin, G.; Malechka, V. V.; Refaian, N.; Bagaev, N.; Labrecque, E.; Vinjamuri, S.; Margeta, M. A.; Baranov, P.

10.1101/2025.05.16.654622 — neuroscience — Posted on 2025-05-21

1991 Antibodies raised against a structurally defined Aβ oligomer mimic protect human iPSC neurons from Aβ toxicity at sub-stoichiometric concentrations

Ruttenberg, S. M.; Dhaoui, R.; Kreutzer, A. G.; Nowick, J. S.

10.1101/2025.05.16.654602 — neuroscience — Posted on 2025-05-21

1992 Estradiol treatment enhances neurovascular coupling independent of metabolic health status in a mouse model of menopause

Plumley, Z. M.; Calvo Iglesias, J.; Fernandez Ugidos, I.; Walker, A. B.; Pires dos Santos, I.; Taylor, H.; Mostany, R.

10.1101/2025.05.21.655189 — neuroscience — Posted on 2025-05-21

1993 Basophils activate splenic B cells and Dendritic cells via IL-13 signaling in acute Traumatic Brain Injury

olde Heuvel, F.; Zhang, J.; Sun, F.; Krishnamurthy, S. S.; Yartas, G.; Pagliarini, M.; Schaefer, M.; Huber-Lang, M.; Roselli, F.

10.1101/2025.05.20.655028 — neuroscience — Posted on 2025-05-21

1994 Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion

Ahlgreen, O. A.; Hansen, M. W.; Baake, J.; Hybel, T. E.; Rossi, R.; Lai, X.; Sankaranarayanan, I.; Pold, J. A.; Lin, L.; Reinert, L. S.; Palludan, S. R.; Price, T. J.; Pallesen, L. T.; Vaegter, C. B.

10.1101/2025.05.19.654813 — neuroscience — Posted on 2025-05-21

1995 Pupil responses indicate task-relevance and (unsuccessful) inhibition of background sounds during a dual, continuous listening task

Fiedler, L.; Johnsrude, I.; Wendt, D.

10.1101/2025.05.20.655069 — neuroscience — Posted on 2025-05-21

1996 GEM-pRF: GPU-Empowered Mapping of Population Receptive Fields for Large-Scale fMRI Analysis

Mittal, S.; Woletz, M.; Linhardt, D.; Windischberger, C.

10.1101/2025.05.16.654560 — neuroscience — Posted on 2025-05-21

1997 Hippocampal time cell dynamics evolve with learning to reflect cognitive demands

Bigus, E. R.; Bowler, J. C.; Azhar, D.; Zukowsky, D.; Heys, J. G.

10.1101/2025.05.20.655191 — neuroscience — Posted on 2025-05-21

1998 Neuromodulators control neuronal dynamics through feature space reshaping

Guarino, D.; Carannante, I.; Destexhe, A.

10.1101/2025.05.19.654470 — neuroscience — Posted on 2025-05-21

1999 Spatio-molecular analysis of primate subthalamus defines anatomical domains relevant to Parkinson disease and neuropsychiatry

Dumas, S.; Francois, C.; Karachi, C.; Mackenzie, A.

10.1101/2025.05.21.655268 — neuroscience — Posted on 2025-05-21

2000 Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo

Amurrio, E.; Patel, J.; Danaher, M.; Elzaree, L.; Fisher, J. L.; Greene, H.; Kargbo, P.; Kim, P.; Klimentova, E.; Lin, S.; Liu, Y.; Abdella, S.; Mehboob, M. Y.; Temesgen, Y.; Mahmood, S.; Rotella, D. P.; Kelly, M.

10.1101/2025.05.20.654583 — neuroscience — Posted on 2025-05-21

2001 The Molecular Architecture of Somatic Spines of the Lateral Septum

Hacker, D.; Weisheim, E.; Schweizer, M.; Schneeweiss, U.; Brecht, M.; Mikhaylova, M.

10.1101/2025.05.19.654857 — neuroscience — Posted on 2025-05-21

2002 Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins

Duan, X.; Zhang, C.; Ott, S.; Zhang, Z.; Ruse, C.; Dannhaeuser, S.; Jacobi, R.; Ehmann, N.; Sachidanandan, D.; Nagel, G.; Heckmann, M.; Kittel, R.; Gottschalk, A.; Claridge-Chang, A.; Gao, S.

10.1101/2025.05.20.654571 — neuroscience — Posted on 2025-05-21

2003 Re-enacting steps supports human path integration consistent with motor-corrected grid cell drift

Reisner, V.; Koenig, L.; Studenyak, V.; Becu, M.; Bicanski, A.; Doeller, C. F.

10.1101/2025.05.18.654711 — neuroscience — Posted on 2025-05-21

2004 Adeno-associated virus delivered Cre recombinase as a versatile strategy for modeling focal neuronal lesions

Giraudet, M.; Cloarec, E.; Gambino, F.; Augusto, E.

10.1101/2025.05.20.655018 — neuroscience — Posted on 2025-05-21

2005 Transcranial magnetic vs intracranial electric stimulation: a direct comparison of their effects via scalp EEG recordings

Comolatti, R.; Hassan, G.; Mikulan, E.; Russo, S.; Colombo, M.; Litterio, E.; Furregoni, G.; D'ambrosio, S.; Fecchio, M.; Parmigiani, S.; Sartori, I.; Casarotto, S.; Pigorini, A.; Massimini, M.

10.1101/2025.05.21.654985 — neuroscience — Posted on 2025-05-21

2006 Semi-automatic Geometrical Reconstruction and Analysis of Filopodia Dynamics in 4D Two-Photon Microscopy Images

Brence, B.; Brummer, J.; Dercksen, V. J.; Ozel, M. N.; Kulkarni, A.; Wolterhoff, N.; Prohaska, S.; Hiesinger, P. R.; Baum, D.

10.1101/2025.05.20.654789 — neuroscience — Posted on 2025-05-21

2007 Aligning Neural Population Patterns Facilitates Motor Learning Transfer

Zhang, X.; Song, Z.; Shen, X.; Chen, S.; Huang, Y.; Wang, Y.

10.1101/2025.05.16.654614 — neuroscience — Posted on 2025-05-21

2008 Characterising the association between posterior parietal metabolite levels and cortical macrostructure in a cohort spanning childhood to adulthood.

Thomson, A. R.; pasanta, d.; Edden, R. A. E.; Arichi, T.; Chai, X. J.; Puts, N.

10.1101/2025.05.20.655054 — neuroscience — Posted on 2025-05-21

2009 Sex-Specific Neural Adaptations to Acute and Chronic Restraint Stress in Mice

Li, A.-J.; McGraw, M.; Landsparger, H.; Benjamin, L.; Qualls-Creekmore, E.

10.1101/2025.05.20.655203 — neuroscience — Posted on 2025-05-21

2010 Methamphetamine modulates functional connectivity signatures of sustained attention and arousal

Lyu, Y.; Corriveau, A.; Molla, H.; de Wit, H.; Rosenberg, M. D.

10.1101/2025.05.20.655181 — neuroscience — Posted on 2025-05-21

2011 Neuronal oscillations predict un-cued task switching in the Wisconsin card sorting test

Sattelberger, J.; Haque, H.; Liu, M.; Simola, J.; Palva, J. M.; Halassa, M.; Palva, S.

10.1101/2025.05.19.654819 — neuroscience — Posted on 2025-05-21

2012 Multimodal Human Perception of Object Dimensions: Evidence from Deep Neural Networks And Large Language Models

Burger, F.; Varlet, M.; Quek, G.; Grootswagers, T.

10.1101/2025.05.19.654977 — neuroscience — Posted on 2025-05-21

2013 Flexible sensitivity to inputs during skilled tongue movements

Dasgupta, R.; Dong, M.; O'Connor, D. H.

10.1101/2025.05.18.654702 — neuroscience — Posted on 2025-05-21

2014 Region- and stage-specific cortical plasticity shapes the multifaceted process of habit formation

Asaoka, N.; Hayashi, Y.

10.1101/2025.05.19.654900 — neuroscience — Posted on 2025-05-21

2015 Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia

Guldner, I. H.; Wagner, V. P.; Moran Losada, P.; Shi, S. M.; Chen, K.; Meese, B. T.; Oh, H.; Le Guen, Y.; Lu, N.; Wong, P. S.; To, N.-S.; Garceau, D.; Guo, Z.; Luo, J.; Sasner, M.; Keller, A.; Yang, A. C.; Cheung, T.; Wyss-Coray, T.

10.1101/2025.05.20.654652 — neuroscience — Posted on 2025-05-21

2016 Frontostriatal salience network expands as executive networks contract in Obsessive-Compulsive Disorder

Vaghi, M. M.; Norgaard, M.; Shim, S.; Rios, J. A. H.; Bissett, P. G.; Rodriguez, C. I.; Poldrack, R. A.

10.1101/2025.05.21.654808 — neuroscience — Posted on 2025-05-21

2017 The Neural Architecture of Dream Recall Frequency: Insights from Interindividual Variations in Brain Structure and Function

Pereira, M.; Galdi, P.; Mei, T.; Rutiku, R.; Mikkelsen, I. K.; Llera, A.; Scheeringa, R.; Beckmann, C.; Krause, F.; Dresler, M.; Sandberg, K.

10.1101/2025.05.20.655114 — neuroscience — Posted on 2025-05-21

2018 Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation

10.1101/2025.05.20.655167 — animal behavior and cognition — Posted on 2025-05-21

2019 Dynamics of mound repair behavior in termites

Varma Raja, S.; Vats, A.; Prasad, P.; Pandey, C. K.; Sane, S. P.

10.1101/2025.05.19.654859 — animal behavior and cognition — Posted on 2025-05-21

2020 Revisiting the habitat selection of a specialist forest bird, Scolopax rusticola, during its wintering in the Mediterranean region

Beaumelle, C.; Barbet, J.; Cuby, A.; Chautan, M.; Etienne, F.; Martel, M.; Du Roure, A.; Chabanne, R.; Lauer, E.; Le Rest, K.

10.1101/2025.05.19.654177 — animal behavior and cognition — Posted on 2025-05-21

2021 A low-cost immersive Virtual Reality system to study social interactions and collective behavior in fish

Sanchez, S.; Escobedo, R.; Bastien, R.; Denis, A.; Moreau, M.; Combe, M.; Straw, A. D.; Sire, C.; Theraulaz, G.

10.1101/2025.05.20.655100 — animal behavior and cognition — Posted on 2025-05-21

2022 The influence of bee movements on patterns of pollen transfer between plants: an exploratory model

Mailly, J.; Besognet, T.; Lihoreau, M.; Riotte-Lambert, L.

10.1101/2025.05.19.654816 — animal behavior and cognition — Posted on 2025-05-21

2023 Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

Brezzo, G.; Zera, K. A.; Straus, D. E.; Goertz, J. E.; Loppi, S. H.; Crumpacker, R. R.; Frye, J. B.; Becktel, D. A.; Cuartero, M. I.; Culebras, A. G.; Dames, C.; Berchtold, D.; Fowler, J. H.; Meisel, A.; Anrather, J.; Moro, M. A.; Allan, S. M.; Doyle, K.; Buckwalter, M. S.; McColl, B. W.

10.1101/2025.05.21.655267 — animal behavior and cognition — Posted on 2025-05-21

2024 Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic Line

Renken, K.; Masseck, O. A.

10.1101/2025.05.21.655260 — animal behavior and cognition — Posted on 2025-05-21

2025 Advancing spatially explicit fisheries management with age-specific species distribution models

Ward, E. J.; Tolimieri, N.

10.1101/2025.02.27.640560 — ecology — Posted on 2025-05-21

2026 Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish

Wang, Y.; Nguyen, T.; He, Q.; Has, O.; Forouzesh, K.; Eom, D. S.

10.1101/2023.11.08.566303 — developmental biology — Posted on 2025-05-21

2027 Bona fide hematopoietic stem cells in zebrafish originate from the supra-intestinal artery

Feng, S.; Qu, R.; He, Y.; Huang, T.; Wang, Y.; Trinh, T. H.; Cheng, K.; Zhao, S.; Huang, Y.; Zhu, H.; He, S.; Wen, Z.

10.1101/2025.05.20.655066 — developmental biology — Posted on 2025-05-21

2028 Beyond the Axoneme: Whole-Cell Proteomics Identifies Novel Regulators of Ciliogenesis in Xenopus Epidermal Multiciliated Cells

Xu, X.; Yu, Y.; Zheng, T.; Clark, F.; Ross, J.; Tavares, A. L. P.; Wei, S.; Sun, J.

10.1101/2025.05.20.655211 — developmental biology — Posted on 2025-05-21

2029 Transcriptional Repression of reaper by Stand Still Safeguards Female Germline Development in Drosophila

Matsui, M.; Kawaguchi, S.; Kai, T.

10.1101/2025.05.17.654630 — developmental biology — Posted on 2025-05-21

2030 SOX2-VSX2 Co-Occupancy Shapes Retinal Neurogenesis Through Dynamic Chromatin Regulation

Bian, F.; Golestaneh, K.; Davis, E.; Khan, A.; Daghsni, M.; Flohr, K.; Liu, S.; da Silva, S.; Pennacchio, L.; Al Diri, I.

10.1101/2025.05.19.654956 — developmental biology — Posted on 2025-05-21

2031 Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Russell, A.; Eng, T.; Amack, J. D.; Pruyne, D.

10.1101/2025.05.17.654676 — developmental biology — Posted on 2025-05-21

2032 Lineage Analysis and Molecular Characterization of Bergmann Glia-like Progenitors in the Postnatal Mouse Cerebellum using in vivo Electroporation and Spatial Transcriptomics

Suyama, K.; Adachi, T.; Isogai, E.; Hasegawa, I.; Nishitani, K.; Mizuno, M.; Kaiyuan, J.; Miyashita, S.; Owa, T.; Hoshino, M.

10.1101/2025.05.20.655231 — developmental biology — Posted on 2025-05-21

2033 Metabolic and ribosomal dysregulation drive developmental arrest of Schistosoma japonicum in non-permissive rats

Wang, Y.; Tang, E.; Cheng, S.; Chen, X.; Cheng, W.; Hong, Y.; Hu, W.; Wang, J.

10.1101/2025.05.20.655015 — developmental biology — Posted on 2025-05-21

2034 Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output

Sinha, N.; Israely, S.; Ben Harosh, O.; Harel, R.; Dewald, J.; Prut, Y.

10.1101/2024.05.21.595172 — neuroscience — Posted on 2025-05-21

2035 Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons

Li, Z.; Kaur, N.; Santpere, G.; Muchnik, S. K.; Sindhu, S. K.; Qi, C.; Shibata, M.; Clement, O.; Klaric, T. S.; Martin, X. d.; Luria, V.; Cho, H.; Li, M.; Shibata, A.; Tebbenkamp, A. T. N.; Ma, S.; Han, W.; Kim, S. K.; Pochareddy, S.; Phan, D. Q.; Xing, X.; Bao, Y.; Xu, X.; Gladwyn-Ng, I. E.; Cullen, H. D.; Paolino, A.; Fenlon, L. R.; Kozulin, P.; Suarez, R.; Risgaard, R. D.; Gulden, F. O.; Karger, A.; Suzuki, I. K.; Hirata, T.; Gobeske, K. T.; Richards, L. J.; Sousa, A. M. M.; Heng, J. I.; Sestan, N.

10.1101/2025.05.20.652233 — neuroscience — Posted on 2025-05-21

2036 An anthropoid/strepsirrhine divergence in ventral visual stream connectivity

Hunt, J. E.; Warrington, S.; Roumazeilles, L.; Jbabdi, S.; Molnar, Z.; Sotiropoulos, S. N.; Mars, R. B.

10.1101/2025.05.19.653861 — neuroscience — Posted on 2025-05-21

2037 Differential patterns of cortical expansion in fetal and preterm brain development

da Silva, M.; Liang, K.; Garcia, K. E.; Cardoso, J.; Robinson, E. C.

10.1101/2025.05.19.653958 — neuroscience — Posted on 2025-05-21

2038 Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain AT1 Receptor Expression

Motzko Noto, N.; Robison, L. S.; Speth, R. C.

10.1101/2025.05.16.654535 — neuroscience — Posted on 2025-05-21

2039 Particular sequence characteristics induce bias in the detection of polymorphic transposable element insertions

Verneret, M.; Le, V. A.; Faraut, T.; Turpin, J.; Lerat, E.

10.1101/2024.09.25.614865 — bioinformatics — Posted on 2025-05-21

2040 stFormer: a foundation model for spatial transcriptomics

Cao, S.; Yang, K.; Cheng, J.; Shen, H.-B.; Pan, X.; Yuan, Y.

10.1101/2024.09.27.615337 — bioinformatics — Posted on 2025-05-21

2041 The coordination between CTCF, cohesin and TFs impacts nucleosome repositioning and chromatin insulation to define state specific 3D chromatin folding

Do, C.; Jiang, G.; Cova, G.; Zappile, P.; Heguy, A.; Skok, J. A.

10.1101/2024.11.02.620823 — genomics — Posted on 2025-05-21

2042 Density-dependent feedback limits the spread of a beta-lactamase mutant: experimental observations and population dynamic model

Ruelens, P.; de Ridder, E.; de Visser, A.; Wortel, M. T.

10.1101/2023.09.02.555988 — evolutionary biology — Posted on 2025-05-21

2043 Gene regulatory dynamics during craniofacial development in a carnivorous marsupial

Cook, L. E.; Feigin, C. Y.; Hills, J. D.; Vespasiani, D. M.; Pask, A. J.; Gallego Romero, I.

10.1101/2023.02.13.528361 — developmental biology — Posted on 2025-05-21

2044 Direct binding of arsenicals to nuclear transport factors disrupts nucleocytoplasmic transport

Lorentzon, E.; Lee, J.; Masaryk, J.; Keuenhof, K.; Karlsson, N.; Galipaud, C.; Madsen, R.; Hoog, J. L.; Levin, D. E.; Tamas, M. J.

10.1101/2025.01.13.632748 — cell biology — Posted on 2025-05-21

2045 Archaeal SegAB forms a bipolar structure that promotes chromosome segregation in spherical cells

Charles-Orszag, A.; Lord, S. J.; Herrera, N.; Strauskulage, L.; Bhowmick, A.; Goddard, T.; Wassmer, B.; van Wolferen, M.; Asper, G.; Flis, A.; Rodriguez, J.; Redding, S.; Rosenberg, O.; Albers, S.-V.; Mullins, D.

10.1101/2025.04.15.649018 — cell biology — Posted on 2025-05-21

2046 Intracellular competitions reveal the combination of active partitioning and addiction mechanisms as most advantageous for low-copy plasmid fitness

Effe, J.; Santer, M.; Wang, Y.; Feenstra, T. E.; Huelter, N. F.; Dagan, T.

10.1101/2025.02.11.637630 — microbiology — Posted on 2025-05-21

2047 Effects of parental care on skin microbial community composition in poison frogs

Fischer, M.-T.; Xue, K. S.; Costello, E. K.; Dvorak, M.; Robaczewska, A.; Raboisson, G.; Caty, S. N.; Relman, D. A.; O'Connell, L. A.

10.1101/2024.09.11.612488 — microbiology — Posted on 2025-05-21

2048 Effects of focal epilepsy and aging on discrimination and reactivation of memories

Tai, X. Y.; Sen, A.; Husain, M.; Manohar, S. G.

10.1101/2024.05.13.593984 — neuroscience — Posted on 2025-05-21

2049 Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats

Lalanza, J. F.; Oyem, J. C.; Huijgens, P. T.; McCutcheon, J. E.; Heijkoop, R.; Snoeren, E. M. S.

10.1101/2024.10.14.618156 — neuroscience — Posted on 2025-05-21

2050 Crossing effects in the tactile temporal order judgment task: A meta-analysis

Schmelter, N.; Langenberg, B.; Mayer, A.; Heed, T.

10.1101/2025.05.05.652194 — neuroscience — Posted on 2025-05-21

2051 Evolution of sensory systems underlies the emergence of predatory feeding behaviours in nematodes

Roca, M.; Eren, G. G.; Boeger, L.; Didenko, O.; Lo, W.-s.; Scholz, M.; Lightfoot, J. W.

10.1101/2025.03.24.644997 — neuroscience — Posted on 2025-05-21

2052 Cardiac-specific GCN5L1 deficiency promotes MASLD in HFpEF

Bugga, P.; Mushala, B. A.; Stoner, M. W.; Manning, J. R.; Bhattarai, N.; Sharifi-Sanjani, M.; Vandevender, A.; Mooli, R. G.; Ramakrishnan, S. K.; Kaufman, B. A.; Shiva, S. S.; Happe, C. L.; Mullett, S. J.; Gelhaus, S. L.; Jurczak, M. J.; Scott, I.

10.1101/2025.02.05.636634 — physiology — Posted on 2025-05-21

2053 Emergence of Pareto distributions in intracellular protein activity through interaction-driven modulation

Yonekura, N.; Deguchi, S.

10.1101/2025.05.16.654514 — biophysics — Posted on 2025-05-21

2054 Nanotopographic Control of Actin Waves and Growth Cone Navigation in Developing Neurons

Pathak, S.; O'Neill, K. M.; Robinson, E. K.; Hourwitz, M. J.; Herr, C.; Fourkas, J. T.; Giniger, E.; Losert, W.

10.1101/2025.05.16.654525 — biophysics — Posted on 2025-05-21

2055 acmgscaler: An R package and Colab for standardised gene-level variant effect score calibration within the ACMG/AMP framework

Badonyi, M.; Marsh, J. A.

10.1101/2025.05.16.654507 — bioinformatics — Posted on 2025-05-21

2056 PG-SCUnK: measuring pangenome graph representativeness using Single-Copy and Universal K-mers

Cumer, T.; Milia, S.; Leonard, A. S.; Pausch, H.

10.1101/2025.04.03.646777 — bioinformatics — Posted on 2025-05-21

2057 Multiplexed Molecularly-Specific SWCNT Cytokine Sensing is Enabled and Enhanced by Amine-Functionalized DNA Aqueous Two-Phase Extraction

Ryan, A.; Parveen, S.; Cohen, Z.; Israel, A.; Williams, R. M.

10.1101/2025.05.16.654499 — bioengineering — Posted on 2025-05-21

2058 Depth-Sensitive Assessment of Cerebral Blood Flow and Low-Frequency Oscillations After Traumatic Brain Injury in Mice Using Time-Gated Diffuse Correlation Spectroscopy

Sabaghian, S.; Poon, C.-S.; Langri, D. S.; Rambo, T. M.; Miller, A. J.; Foreman, B.; Sunar, U.

10.1101/2025.05.16.654521 — bioengineering — Posted on 2025-05-21

2059 Closed-form expression for the directions of maximum modulation depth in temporal interference electrical brain stimulation.

Corazza, M. F.; Turovets, S.; Muravchik, C. H.

10.1101/2025.05.16.654079 — bioengineering — Posted on 2025-05-21

2060 Oncogenic drivers shape the tumor microenvironment in human gliomas

Zhao, B.; Cho, C. Y.; Ye, L.; Keal, T.; Mitchell, T. J.; Martin-Barrio, I.; Weinberg, J. S.; Huse, J. T.; Dixon, J. R.; Lang, F. F.; Akdemir, K. C.

10.1101/2025.05.16.654515 — genomics — Posted on 2025-05-21

2061 Engineering precision zebrafish alleles of human disease

Thomas, H. R.; Yoder, B. K.; Alexander, M. S.; Parant, J. M.

10.1101/2025.05.18.654701 — genetics — Posted on 2025-05-21

2062 Interchromosomal Linkage Disequilibrium Analysis Reveals Strong Indications of Sign Epistasis in Wheat Breeding Families

Tessele, A.; Morris, G. P.; Akhunov, E.; Johnson, B. E.; Clinesmith, M.; Fritz, A. K.

10.1101/2025.05.16.654524 — genetics — Posted on 2025-05-21

2063 Soft tissue constraints on joint mobility in the avian shoulder

Demuth, O. E.; Hutchinson, J. R.; La Barbera, V.; Warner, S. E.; Field, D. J.

10.1101/2025.05.16.654461 — evolutionary biology — Posted on 2025-05-21

2064 Mutation rate variability in viral populations: implications for lethal mutagenesis

Arcos, S.; Lauring, A. S.

10.1101/2025.05.16.654520 — evolutionary biology — Posted on 2025-05-21

2065 Spatial and single-nucleus transcriptomic profile of a chimpanzee frontal pole

Alagöz, G.; Wong, M.; Grässle, T.; Jäger, C.; Morawski, M.; Kolleck, J.; Francks, C.; Wittig, R. M.; Crockford, C.; Gunz, P.; Fisher, S. E.

10.1101/2025.02.16.638510 — evolutionary biology — Posted on 2025-05-21

2066 Limits and Promises of Earth Observation Foundation Models in Predicting Multi-Trophic Soil Biodiversity

Cerna, S.; Si-Moussi, S.; Calderon-Sanou, I.; Miele, V.; Thuiller, W.

10.1101/2025.05.16.654504 — ecology — Posted on 2025-05-21

2067 Characterization and Bioactivity Potential of Marine Sponges (Biemna fistulosa, Callyspongia diffusa, and Haliclona fascigera) from Kenyan Coastal Waters

WACIRA, T. N.; Makonde, H. M.; Kamau, J. N.; Aura, C. M.; Kibiti, C. M.

10.1101/2025.05.20.655062 — microbiology — Posted on 2025-05-21

2068 Burkholderia Genes Involved in Extracellular Bioplastic Degradation Revealed by Tn-seq and CRISPR-Cas

Yap, Z. L.; Lucas, G. G.; Safklou, M.; Darragh, R.; Hogan, A. M.; Motnenko, A.; Blunt, W.; Sparling, R.; Levin, D. B.; Fernandez Do Porto, D. A.; Cardona, S. T.

10.1101/2025.05.20.655153 — microbiology — Posted on 2025-05-21

2069 Decoupling bile acid 7α-dehydroxylation from colonization resistance to Clostridioides difficile

Beldi, L.; Dong, Y.; Volet, C.; Tandon, D.; Filipova, K.; Bernier-Latmani, R.; Hapfelmeier, S.

10.1101/2025.05.20.655077 — microbiology — Posted on 2025-05-21

2070 In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-Synucleinopathies

Fouka, M.; Tsakogias, I.; Gialinaki, E. G.; Stavropoulos, A.; Volbracht, C.; De Muynck, L.; Moechars, D.; Melki, R.; Tofaris, G.; Stefanis, L.; Xilouri, M.

10.1101/2025.05.16.653961 — neuroscience — Posted on 2025-05-21

2071 EEG entropy reflects both intrinsic and stimulation-induced corticospinal excitability

Ruch, S.; Frohlich, J.; Keute, M.; Tang, G.; Keksel, N.; Gharabaghi, A.

10.1101/2025.05.16.654439 — neuroscience — Posted on 2025-05-21

2072 THC Reverses SIV-Induced Senescence in Astrocytes: Possible Compensatory Mechanism Against HIV Associated Brain Injury?

Van Zandt, A.; Horn, M.; Peterson, T.; Dickinson, S.; Frost, E.; MacLean, A.

10.1101/2025.05.16.654476 — neuroscience — Posted on 2025-05-21

2073 Succinate Modulation as a Novel Mechanism Underlying the Effects of Intermittent Fasting on Brain Function and Metabolism in Diet-Induced Obesity

Tognozzi, A.; Carli, F.; Abdelkarim, S.; Cornuti, S.; Damiani, F.; Giuliano, M. G.; Miniati, A.; Nasisi, M.; de Benedictis, L.; Ashtiani, K. C.; Scabia, G.; Maffei, M.; Baldi, P. F.; Gastaldelli, A.; Tognini, P.

10.1101/2025.05.16.654006 — neuroscience — Posted on 2025-05-21

2074 Weight-bearing symmetry changes after asymmetric surface stiffness walking

Price, M. A.; Schell, E.; Jaramillo, J. M.; Chiasson, J.; Metsker, L.; Huber, M. E.; Hoogkamer, W.

10.1101/2025.05.16.654517 — neuroscience — Posted on 2025-05-21

2075 Machine Learning Matches Human Performance at Segmenting the Human Visual Cortex

Benson, N. C.; Song, B.; Chen, S.; Miyata, T.; Takemura, H.; Winawer, J.

10.1101/2025.05.16.654503 — neuroscience — Posted on 2025-05-21

2076 Neural correlates of consciousness in an auditory no-report fMRI study

Dellert, T.; Balster, H.; Schlossmacher, I.; Bruchmann, M.; Moeck, R.; Straube, T.

10.1101/2025.05.16.654468 — neuroscience — Posted on 2025-05-21

2077 Energy and time trade-offs explain everyday human reaching movements

Wong, J. D.; Herspiegel, W. J.; Kuo, A. D.

10.1101/2025.05.16.654498 — neuroscience — Posted on 2025-05-21

2078 Autonomic responses to proprioceptive and visual errors during single-trial reach adaptation

Nogami, M.; Hagura, N.; Yokoi, A.

10.1101/2025.03.31.646172 — neuroscience — Posted on 2025-05-21

2079 Decreased female survival may explain wild turkey decline

Lashley, M. A.; Chitwood, M. C.; Moeller, A. K.; Gulsby, W. D.; Potash, A. D.; O'Neil, K.; Turner, M.

10.1101/2025.05.16.654534 — zoology — Posted on 2025-05-21

2080 Cytoplasmic CaMKIIδ-B prevents myocardial recovery in heart failure

Martin, T. G.; Hunt, D. R.; Ebmeier, C. C.; Dhand, A. P.; Alamana, C.; Cleveland, J. C.; Graw, S. L.; Bruner, S.; Bristow, M. R.; Mestroni, L.; Taylor, M. R.; Burdick, J. A.; Ambardekar, A. V.; Buttrick, P. M.; Leinwand, L. A.

10.1101/2025.05.16.654509 — physiology — Posted on 2025-05-21

2081 From Movement to METs: A Validation of ActTrust(R) for Energy Expenditure Estimation and Physical Activity Classification in Young Adults

dos Santos Batista, E.; Basilio Gomes, S. R.; Bruno de Morais Ferreira, A.; Franca, L. G. S.; Fontenele Araujo, J.; Mortatti, A. L.; Leocadio-Miguel, M. A.

10.1101/2025.05.16.654458 — bioinformatics — Posted on 2025-05-21

2082 Accelerate the discovery of genetic variants in mitochondrial diseases with VIOLA: Variant PrIOritization using Latent space

Labory, J.; Boulaimen, Y.; Singh, J.; AIT-EL- MKADEM SAADI, S.; Paquis, V.; Bannwarth, S.; BOTTINI, S.

10.1101/2025.05.16.654430 — bioinformatics — Posted on 2025-05-21

2083 Female Anterior Cruciate Ligaments Exhibit a Muted Mechanobiological Response to Mechanical Loading

Paschall, L.; Konnaris, M.; Tabdanov, E. D.; Dhawan, A.; Szczesny, S.

10.1101/2025.05.16.654473 — bioengineering — Posted on 2025-05-21

2084 Sundoli: A necro(w)bot with multi-stiffness joints built using geared mechanical metastructures

Lee, H.; Mack, J.; Alam, P.

10.1101/2025.05.16.654441 — bioengineering — Posted on 2025-05-21

2085 Robust Deep Denoising of Soft X-Ray Tomography Data for Biological Research: Targeting Tilt Series Versus Reconstructed Tomograms

Chueh, S.; Simpson, J. C.; Kapishnikov, S.

10.1101/2025.05.16.654457 — bioengineering — Posted on 2025-05-21

2086 Chemically responsive protein switches for the precise control of biological activities

Franco Pinto, J.; Drahy, N.; Divoux, S.; Perez, F.; Gautier, A.

10.1101/2025.05.16.654305 — bioengineering — Posted on 2025-05-21

2087 The environmental dependence of ecological interactionnetworks

Parisy, B.; Cirtwill, A. R.; Roslin, T.

10.1101/2025.05.16.654471 — ecology — Posted on 2025-05-21

2088 Quantifying ecosystem degradation via energetic deficits

Angulo, M. T.; Liu, Y.; Morris, D.; Saavedra, S.

10.1101/2025.05.16.654496 — ecology — Posted on 2025-05-21

2089 Understanding the Neuro-Cognitive Mechanisms of Orthographic Learning in Humans and Baboons: A Comparative Study Using Domain-Specific Mechanistic and Domain-General Connectionist Models

Pauli, J. N. J.; Gagl, B.

10.1101/2025.05.16.654419 — neuroscience — Posted on 2025-05-21

2090 Off-target interaction of the amyloid PET imaging tracer PiB with acetylcholinesterase

Granzotto, A.; Fullone, R.; Miccoli, L.; Bomba, M.; Di Marzio, C.; Delli Pizzi, S.; Floresta, G.; Sensi, S. L.

10.1101/2025.05.16.654428 — neuroscience — Posted on 2025-05-21

2091 Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added In Silico Predictions and 2D PK-Space Positioning

Fagerholm, U.

10.1101/2025.05.05.652242 — pharmacology and toxicology — Posted on 2025-05-21

2092 A Deep Learning approach for time-consistent cell cycle phase prediction from microscopy data

Bonte, T.; Pourcelot, O.; Safieddine, A.; Slimani, F.; Mueller, F.; Weil, D.; Bertrand, E.; Walter, T.

10.1101/2025.05.16.654306 — bioinformatics — Posted on 2025-05-21

2093 NewroBus for the brain: humanized TfR1-targeting nanobodies with high BBB permeability and cargo transport capacity

Yin, T.; Yesiltepe, M.; Metkar, S.; Ramon, A. E.; Greening, M.; Sormanni, P.; D'Adamio, L.

10.1101/2025.04.20.649139 — bioengineering — Posted on 2025-05-21

2094 Quercetin treatments alleviate production, egg quality, blood metabolites, and anti-oxidant defence in laying hens : A meta-analysis study

Hartanto, S.; Wardono, H. P.; Kurnianto, H.; Hantoro, F. R. P.; Prasetyo, A.; Haryanto, B.; Hayati, R. N.; Ludfiani, D. D.; Purwasih, R.; Yano, A. A.; Sujiwo, J.; Jang, A.; Sugiharto, S.

10.1101/2025.05.16.654414 — animal behavior and cognition — Posted on 2025-05-21

2095 Synchronous Hatching of 2-Day Delayed Intruders in Reproductive Competition in the Burying Beetle

Niida, T.; Nisimura, T.

10.1101/2025.05.16.654448 — animal behavior and cognition — Posted on 2025-05-21

2096 Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

Hoffman, R. A.; Wang, M.; Sunkel, B. D.; Nguyen, T. H.; Lopez-Nava, J.; Chatterjee, B.; Sun, W.; Barr, F. G.; Stanton, B. Z.

10.1101/2025.05.16.654522 — genomics — Posted on 2025-05-21

2097 Progressive neuroinflammation and deficits in motor function in a mouse model with an Epg5 pathogenic variant of Vici syndrome

Thornton, B. T.; Hardinger, A. G.; Pence, L.; Prem Kumar, P.; Connolly, N.; Weir, S. J.; Vivian, J. L.

10.1101/2025.05.16.654529 — genetics — Posted on 2025-05-21

2098 The Genome of Chenopodium ficifolium: Developing Genetic Resources and a Diploid Model System for Allotetraploid Quinoa

Ludwig, C. D.; Maughan, P. J.; Jellen, E. N.; Davis, T. M.

10.1101/2025.01.17.633571 — genetics — Posted on 2025-05-21

2099 Pollinator and flower morphology interact to influence pollen receipt

Newman, E. L.; Ellis, A.; Anderson, B.

10.1101/2025.05.16.654420 — evolutionary biology — Posted on 2025-05-21

2100 Phenology and flower species availability define wild bee communities on river embankments

Swinkels, C.; Slikboer, L.; Raemakers, I.; Godijn, N.; Jongejans, E.; de Kroon, H.

10.1101/2025.05.16.653962 — ecology — Posted on 2025-05-21

2101 The profiles of mammals, birds and fish in twelve water bodies on the Island of Montreal by mitochondrial DNA: detection of invasive animals and meat and fish waste

Villemur, R.

10.1101/2025.05.16.654469 — ecology — Posted on 2025-05-21

2102 The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

Weerdmeester, L.; Schleimer, J.-H.; Schreiber, S.

10.1101/2024.09.24.614486 — neuroscience — Posted on 2025-05-21

2103 Neural Sharpening of Object Categories Through Parafoveal Priming

Wynn, S. C.; Bezsudnova, Y.; Jensen, O.

10.1101/2025.05.16.654463 — neuroscience — Posted on 2025-05-21

2104 A Neurocognitive Shift in Midlife: Linking Cognitive Flexibility and Functional-Metabolic Adaptation with the SENECA model

Guichet, C.; Achard, S.; Mermillod, M.; Baciu, M.

10.1101/2025.05.16.654421 — neuroscience — Posted on 2025-05-21

2105 Western diet reversibly alters the olfactory mucosa and impairs the response to appetitive food cues

Eygret, L.; Aruci, E.; Canova, V.; Paradis, J.; Soubeyre, V.; Chomel, T.; Capoduro, R.; Grosmaitre, X.; Fioramonti, X.; Jarriault, D.

10.1101/2025.05.16.654424 — neuroscience — Posted on 2025-05-21

2106 A large 3D-printed integrated lens-biprism element enhances contrast in transmission stereomicroscopy

Rooney, L. M.; Amos, W. B.; Foylan, S.; Christopher, J.; Butterworth, C.; Bauer, R.; Gould, G. W.; McConnell, G.

10.1101/2025.05.20.655140 — biophysics — Posted on 2025-05-21

2107 Antagonism between bacteriophages and macrophages decreases efficacy of a phage cocktail and increases bacteriophage resistance

Castledine, M.; Szczutkowska, Z.; Matthews, A.; Walsh, S. K.; Lewis, R.; Kay, S.; Willment, J. A.; Brown, G. D.; Buckling, A.

10.1101/2025.05.16.654446 — evolutionary biology — Posted on 2025-05-21

2108 Inverted topographies in sequential fitness landscapes enable evolutionary control

Chen, P.; Krishnan, N.; Stacy, A.; Weaver, D. T.; Barker-Clarke, R.; Hinczewski, M.; Maltas, J.; Scott, J. G.

10.1101/2024.12.29.630702 — evolutionary biology — Posted on 2025-05-21

2109 Loss of class 3 PI3K complex leads to retention of Wg at the apical membrane in polarized tissue

Holzem, M.; Pavlovic, B.; Munz, M.; Gerwin, J.; Lampe, M.; Port, F.; Boutros, M.

10.1101/2025.05.20.655092 — developmental biology — Posted on 2025-05-21

2110 A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species

Wang, D.; Ming, H.; Yang, D.; Tsai, L.-K.; Wei, Z.; Scatolin, G. N.; Wang, X.; Yau, K.; Tao, L.; Tong, X.; Wang, S.; Shi, K.-X.; Evseenko, D.; Handel, B. V.; Zhang, B.; Wang, Y.; Iyyappan, R.; Ojeda-Rojas, O. A.; Hu, G.; McGinnis, L.; Paulson, R.; Mckim, D.; Kong, X.; Xia, X.; Zhang, J.; Chen, E. Y.; Xu, J.; Jiang, Z.; Ying, Q.-L.

10.1101/2025.05.20.654948 — cell biology — Posted on 2025-05-21

2111 Purification protocol of hypertrophied hepatic stellate cells for their transcriptomic characterization from CDAHFD mice liver

Heckmann, M.; Djerir, N.-E.-H.; Commere, P.-H.; Fernandes, J.; Sarrabayrouse, G.; Bigey, P.; Escriou, V.; HOFFMANN, C.

10.1101/2025.05.19.654829 — cell biology — Posted on 2025-05-21

2112 Acquisition and repeated alteration of (TTGGG)n telomeric repeats in Odonata (dragonflies and damselflies)

Gotoh, T.; Suzuki, H.; Moriyama, M.; Futahashi, R.; Osanai-Futahashi, M.

10.1101/2025.05.20.653629 — cell biology — Posted on 2025-05-21

2113 OMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity

Koshiba, T.; Nishigori, M.; Hirata, S.; Kosako, H.; Nolte, H.; Riemer, J.; Langer, T.

10.1101/2025.05.19.654756 — cell biology — Posted on 2025-05-21

2114 Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice

Brachova, P.; Alvarez, N.

10.1101/2025.05.19.654918 — cell biology — Posted on 2025-05-21

2115 Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells

Kovacs, P.; Brazda, P.; Hajdu, T.; Harsanyi, B.; Juhasz, K. Z.; Takacs, R. A.; Judit, V.; Wang, Z.; Coveney, C.; Boocock, D. J.; Matta, C.

10.1101/2025.05.19.654853 — cell biology — Posted on 2025-05-21

2116 Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific MYH9 Mutations

Llorente-Gonzalez, C.; Mustafina, K.; Talayero, V. C.; Asensio-Juarez, G.; Garrido-Casado, M.; Sellers, J. R.; Chinthalapudi, K.; Wiseman, P. W.; Heissler, S. M.; Vicente-Manzanares, M.

10.1101/2025.05.20.654665 — cell biology — Posted on 2025-05-21

2117 JAK/STAT Signaling Governs Airway Epithelial Homeostasis and Stress Resilience in Drosophila

Niu, X.; Fink, C.; Kallsen, K.; Shi, L.; Mincheva, V.; Franzenburg, S.; Prange, R. D.; Bruchhaus, I.; Heine, H.; Bossen, J. M.; Roeder, T.

10.1101/2025.05.20.655050 — cell biology — Posted on 2025-05-21

2118 Cancer-Associated USP28 Missense Mutations Disrupt 53BP1 Interaction and p53 Stabilization

Belal, H.; Ng, E. F. Y.; Ohta, M.; Meitinger, F.

10.1101/2025.05.20.655034 — cell biology — Posted on 2025-05-21

2119 Inhibition of TBK1/IKKe mediated RIPK1 phosphorylation sensitizes tumors to immune cell killing

Piskopou, A.; Vredevoogd, D. W.; Kong, X.; Altelaar, M.; Peeper, D. S.; Stecker, K. E.

10.1101/2025.05.20.655064 — cell biology — Posted on 2025-05-21

2120 Exploring the Neural Basis and Validity of Ordinal Emotion Representation through EEG

Chen, X.; Xu, X.; Zhang, D.; Shen, X.

10.1101/2024.11.21.624627 — neuroscience — Posted on 2025-05-21

2121 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy

Li, H.; Xie, Z.; Tian, Y.; Zhou, R.; Yang, Y.; Lin, B.; Chen, S.; Wu, J.; Deng, Z.; Li, J.; Chen, M.; Liu, X.; Sun, Y.; Huang, B.; Wei, N.; Ji, X.

10.1101/2024.10.28.618752 — neuroscience — Posted on 2025-05-21

2122 Multiple weak brakes act in concert to regulate STIM1 and control store-operated calcium entry

Qiu, R.; Lewis, R. S.

10.1101/2025.05.20.655205 — biophysics — Posted on 2025-05-21

2123 The cryo-EM structure of mouse radial spoke 3 reveals a unique metabolic and regulatory hub in cilia

Zhao, Y.; Song, K.; Tavakoli, A.; Gui, L.; Fernandez Gonzalez, A.; Zhang, S.; Dzeja, P. P.; Mitsialis, S. A.; Zhang, X.; Nicastro, D.

10.1101/2025.05.19.654877 — biophysics — Posted on 2025-05-21

2124 Transcriptional activity generates chromatin motion that drives nuclear blebbing

Prince, K.; Lin, K.; Li, A.; Borowski, N.; Stephens, A. D.

10.1101/2025.05.20.655131 — cell biology — Posted on 2025-05-21

2125 Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis.

Perez, K. C.; Alexander, J.; Rahman, M. M.; Alsharif, H. A.; Liu, Y.; Kim, J.-A.; Hunter, C. S.; Nguyen, T. M.; Bhatnagar, S.

10.1101/2025.05.19.654959 — cell biology — Posted on 2025-05-21

2126 SPROUTS_DB: an implemented database of contaminants for extracellular vesicle proteomics studies

Pittala, M. G. G.; Leggio, L.; Paterno, G.; Giusto, E.; Civiero, L.; Cunsolo, V.; Vivarelli, S.; Di Francesco, A.; Alpi, E.; Saletti, R.; Iraci, N.

10.1101/2025.05.20.655024 — cell biology — Posted on 2025-05-21

2127 Real-time imaging of transcriptional feedback in nonsense-mediated mRNA decay

Sato, H.; Islam, M. D.; Das, T.; Singer, R. H.

10.1101/2025.05.20.655238 — cell biology — Posted on 2025-05-21

2128 Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury

Yamamoto, M.; Ash, D.; Sudhahar, V.; Zaidi, S. A. H.; Rojas, M. A.; Xu, Z.; Kelley, S.; Caldwell, R. B.; Fukai, T.; Ushio-Fukai, M.

10.1101/2025.05.17.654687 — cell biology — Posted on 2025-05-21

2129 MINDNet: Proximity interactome of the MICOS complex revealing a multifaceted network orchestrating mitochondrial biogenesis

Schaumkessel, Y.; Brocke-Ahmadinejad, N.; Strohm, R.; Mueller, S.; Reichert, A. S.; Kondadi, A. K.

10.1101/2025.05.20.655052 — cell biology — Posted on 2025-05-21

2130 Unveiling the hidden window of prime editing

Chen, P.-R.; Wei, Y.; Yuan, X.-Z.; Wang, S.-G.; Xia, P.-F.

10.1101/2025.05.20.655067 — synthetic biology — Posted on 2025-05-21

2131 Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma

Barr, T.; Jennings, V. A.; Roundhill, E. A.; Baugh, R. T.; Yamrali, M.; Owston, H.; McGonagle, D.; Giannoudis, P. V.; Caplen, N. J.; Khan, J.; Bell, J. C. C.; Burchill, S. A.; Errington-Mais, F.; Cook, G. P.

10.1101/2025.05.16.654440 — cancer biology — Posted on 2025-05-21

2132 EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma

Carreno-Gonzalez, M. J.; Hanssen, K. M.; Sadik, A.; Henneberg, A.; Ehlers, A. C.; Ceranski, A. K.; Kołodynska, Z. A.; Zimmermann, M.; Imle, R.; Geyer, F. H.; Ritter, A.; Banito, A.; Knott, M. M. L.; Ohmura, S.; Cidre-Aranaz, F.; Opitz, C. A.; Grünewald, T. G. P.

10.1101/2025.05.16.654502 — cancer biology — Posted on 2025-05-21

2133 Chromosome-scale genome assembly of B10.RIII, an autoimmune susceptible mouse strain

Nagarajan, V.; Jittayasothorn, Y.; Shi, G.; Horai, R.; Caspi, R. R.

10.1101/2025.05.16.654505 — immunology — Posted on 2025-05-21

2134 Zika and chikungunya viruses decrease salivation in Aedes aegypti mosquitoes

Souriac, L.; Berni, M.; Voisin, B.; Leite, T. H. J. F.; Marois, E.; Aubry, F.; Marques, J. T.

10.1101/2025.05.16.654423 — immunology — Posted on 2025-05-21

2135 HO-3867 mediated modulation of Extracellular vesicles and Tumor microenvironment: A novel immunotherapeutic strategy for ovarian cancer

Yadagiri, G.; Chakrapani, L. N.; Sundaram, S.; Velasquez, J.; Hughes, T.; Vendrell, G. S.; Bognar, B.; Wang, Q.-E.; O Malley, D. M.; Cohn, D. E.; Karuppaiyah, S.; Dorayappan, K. D. P.

10.1101/2025.05.16.653814 — cancer biology — Posted on 2025-05-21

2136 Kaminari: a resource-frugal index for approximate colored k-mer queries

Levallois, V.; Shibuya, Y.; Le Gal, B.; Patro, R.; Peterlongo, P.; Pibiri, G. E.

10.1101/2025.05.16.654317 — bioinformatics — Posted on 2025-05-21

2137 Riemann-GNN: Causal Reasoning on Hyperbolic Riemannian Manifolds for Interpretable Drug-Disease Prediction

Yang, J.; Puyu, H.; Liu, Q.; Pan, Y.; He, L.; Zhang, L.; Dai, L.; Wang, Y.; Tao, J.

10.1101/2025.05.16.654434 — bioinformatics — Posted on 2025-05-21

2138 CROCKETA: An automated framework for comprehensive multi-omic analysis of gene expression and clonotype immune repertoire at a single-cell level

Soria Alcaide, G.; Garcia Aguilera, G.; Portasany Rodriguez, M.; Lalchandani Lakhani, J.; Gonzalez Murillo, A.; Garcia Sanchez, E.; Saiz Ladera, C.; Ramirez Orellana, M.; Garcia Martinez, J.

10.1101/2025.05.16.654451 — bioinformatics — Posted on 2025-05-21

2139 Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

Lee, K. K.; Lapinska, U.; Tolle, G.; Micaletto, M.; Zhang, B.; Phetsang, W.; Verderosa, A.; Invergo, B. M.; Westley, J.; Bebes, A.; Yuecel, R.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; van Houte, S.; Caboni, P.; Blaskovich, M.; Housden, B.; Tsaneva-Atanasova, K.; Pagliara, S.

10.1101/2024.04.22.590445 — microbiology — Posted on 2025-05-21

2140 Identification of Potential Oral Cancer-Specific Biomarker in Oral Potentially Malignant Disorders for Early Detection of Malignancy: A Systematic Review

Dwivedi, D. D.; Tiwari, P.; Bano, Y.; Kumar, P.; Yadav, C. P.; Singhal, D. K.

10.1101/2025.05.18.651790 — cancer biology — Posted on 2025-05-21

2141 Transcriptomic Signatures of Neuroinflammation and Adaptive Immunity in the Human SCG During Cardiac Disease: A Bulk RNA-seq Reanalysis

Rihan, N.

10.1101/2025.05.18.654713 — bioinformatics — Posted on 2025-05-21

2142 High throuput label free rapid screening to identify cell penetrating peptide

Kumar, V.

10.1101/2025.05.19.654248 — biochemistry — Posted on 2025-05-21

2143 RamanMAE: Masked Autoencoders Enable Efficient Molecular Imaging by Learning Biologically Meaningful Spectral Representations

Paidi, S.; Maheshwari, P.

10.1101/2025.05.18.654618 — biochemistry — Posted on 2025-05-21

2144 Whom Do We Prefer to Learn From in Observational Reinforcement Learning?

Morishita, G.; Murawski, C.; Yadav, N.; Suzuki, S.

10.1101/2025.05.19.654209 — animal behavior and cognition — Posted on 2025-05-21

2145 (De)composing sociality: disentangling individual-specific from dyad-specific propensities to interact

Neumann, C.; Fischer, J.

10.1101/2023.08.15.549768 — animal behavior and cognition — Posted on 2025-05-21

2146 Inferring domestic goat demographic history through ancient genome imputation

Erven, J. A. M.; Etourneau, A.; Mashkour, M.; Neupane, M.; Bardou, P.; Stella, A.; Talenti, A.; Masiga, C. W.; Van Tassel, C. P.; Clark, E. L.; Pompanon, F.; Colli, L.; Amallis, M.; Milanesi, M.; Crepaldi, P.; Consortium, T. V.; Servin, B.; Rosen, B.; Tosser-Klopp, G.; Daly, K. G.

10.1101/2025.04.18.649576 — genomics — Posted on 2025-05-21

2147 Clonal Hematopoiesis Mutations Increase Risk of Alzheimer's Disease with APOE ϵ3/ϵ3 Genotype

Choi, J.; Park, K. S.; Le Guen, Y.; Park, J.-H.; Zhou, Z.; Enyenihi, L.; Rosen, I.; Choi, Y.-H.; Walsh, C. A.; Kim, J.-W.; Huang, A. Y.; Lee, E. A.

10.1101/2025.05.19.654981 — genetics — Posted on 2025-05-21

2148 Environmental Impacts of Dry Vegan Dog Food: A Comprehensive UK Analysis

Gardner, D. S.; Brociek, R. A.

10.1101/2025.05.19.654875 — ecology — Posted on 2025-05-21

2149 Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

Panasenkava, V.; Garreau, J.; Guyodo, H.; Diab, F.; Mahieux, A.; Carre, W.; Verres, Y.; Jullion, E.; Odent, S.; Dubourg, C.; Rollier, P. R.; Dubos, L.; RIBES, V.; Camus, A.; Tayrac, M.; Dupe, V.

10.1101/2025.05.20.654466 — developmental biology — Posted on 2025-05-21

2150 The bipolar-to-multipolar transition of dendrite extension of cerebellar granule neurons requires MTCL2 to link the Golgi apparatus to the microtubule cage.

Minekawa, M.; Suzuki, A.

10.1101/2024.09.12.612747 — cell biology — Posted on 2025-05-21

2151 Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification.

Van der Snickt, T.; Ailliet, S.; Bassini, S.; Peymen, A.; Colaker, A.; Cadoni, E.; Valverde, A.; Daems, E.; Madder, A.; De Wael, K.; Mestdagh, P.; SOCan consortium,

10.1101/2025.05.19.654176 — molecular biology — Posted on 2025-05-21

2152 Clinical, Biological and Pathological Investigation of Bovine Lymphocyte Intestinal Retention Deficit (BLIRD): a new genetic disorder affecting life expectancy and immunity in Holstein dairy cattle

DUTHEIL, L. M. L.; Gausseres, B. B.; Besnard, F. F.; Guzylack-Piriou, L. L.; Abdou Monsef, Y. Y.; Gaide, N. N.; Arnalot, L. L.; Corbiere, F. F.; Gaborit, M. M.; Launay, F. F.; Poujade, A. A.; Capitan, A. A.; Foucras, G. G.

10.1101/2025.05.18.654695 — immunology — Posted on 2025-05-21

2153 Stimulant medications affect arousal and reward, not attention

Kay, B. P.; Wheelock, M. D.; Siegel, J. S.; Raut, R.; Chauvin, R. J.; Metoki, A.; Rajesh, A.; Eck, A.; Pollaro, J.; Wang, A.; Suljic, V.; Adeyemo, B.; Baden, N. J.; Scheidter, K. M.; Monk, J.; Ramirez-Perez, N.; Krimmel, S. R.; Shinohara, R. T.; Tervo-Clemmens, B.; Hermosillo, R. J. M.; Nelson, S. M.; Hendrickson, T. J.; Madison, T.; Moore, L. A.; Miranda-Domlnguez, O.; Randolph, A.; Feczko, E.; Roland, J. L.; Nichol, G. E.; Laumann, T. O.; Marek, S. A.; Gordon, E. M.; Raichle, M. E.; Barch, D. M.; Fair, D. A.; Dosenbach, N. U. F.

10.1101/2025.05.19.654915 — neuroscience — Posted on 2025-05-21

2154 Differential expression of spatiotemporal sleep spindle clusters in ageing

Raud, L.; Smits, M. J. B.; Sneve, M. H.; Ness, H. T.; Folvik, L.; Rasch, B.; Fjell, A. M.

10.1101/2025.05.19.654222 — neuroscience — Posted on 2025-05-21

2155 Differential Effects of Meditation States and Traits on the Neural Mechanisms of Pain Processing

Kolev, V.; Malinowski, P.; Raffone, A.; Nicolardi, V.; Simione, L.; Aglioti, S. M.; Yordanova, J.

10.1101/2025.05.20.655049 — neuroscience — Posted on 2025-05-21

2156 Somato-Motor Network Neural Connectivity Correlates with Visuomotor Adaptation

Song, Y.

10.1101/2025.05.19.654905 — neuroscience — Posted on 2025-05-21

2157 Linking Pregnancy- and Birth-Related Risk Factors to a Multivariate Fusion of Child Cortical Structure

Lindseth, L. R.; Beck, D.; Westlye, L. T.; Tamnes, C. K.; Norbom, L. B.

10.1101/2024.10.29.620834 — neuroscience — Posted on 2025-05-21

2158 PYEAST - Python Enabled Automated Strain Transformaiton

Madika, A.; Suri, A.; Purohit, A.; Van Raad, D.; Norman, M.; Hartley, C.; Loan, T. D.

10.1101/2025.05.19.655004 — synthetic biology — Posted on 2025-05-21

2159 Small language models enable rapid and accurate extraction of structured data from unstructured text: an example with plants and their specialized metabolites

Busta, L.; Oyler, A. R.

10.1101/2025.05.19.654923 — plant biology — Posted on 2025-05-21

2160 Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

Zuarth Gonzalez, J. D.; Ragsdale, A. K.; Mukhopadhyay, S.; McCurdy, C. R.; McMahon, L. R.; Obeng, S.; Wilkerson, J. L.

10.1101/2025.05.16.654392 — pharmacology and toxicology — Posted on 2025-05-21

2161 Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection

Phan, J. R.; Bacab, E.; Washington, M.; Niamba, M.; Do, D. M.; Mata, T. V.; Consul, A.; Blank, L.; Yang, S.; Howerton, A. J.; Heredia, E.; Soriano, R.; Hassan, C.; Cross, C. L.; Abel-Santos, E.

10.1101/2023.07.05.547871 — microbiology — Posted on 2025-05-21

2162 Neurocomputational Mechanisms Linking Future Interaction Prospects to Reactive and Proactive Costly Punishment

Huang, C.; Zhou, X.; Liu, F.; Yang, B.; Zheng, Z.; Li, X.; Yin, Y.; Luo, Y.-J.; Feng, C.

10.1101/2025.05.15.654171 — neuroscience — Posted on 2025-05-21

2163 Meta-analysis on the effects of chemical stressors on freshwater ecosystem functions

Feckler, A.; Schulz, R.; Schaefer, R. B.

10.1101/2023.10.25.563649 — ecology — Posted on 2025-05-21

2164 Membrane potential modulates ERK activity and cell proliferation

Sasaki, M.; Nakahara, M.; Hashiguchi, T.; Ono, F.

10.1101/2024.08.27.610010 — cell biology — Posted on 2025-05-20

2165 Cell Adhesion-Dependent Biphasic Axon Outgrowth Elucidated by Femtosecond Laser Impulse

Yamada, S.; Baba, K.; Inagaki, N.; Yoichiroh, H.

10.1101/2021.10.10.463848 — cell biology — Posted on 2025-05-21

2166 Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

Li, J.; He, Y.; Xu, X.; Alcorlo, M.; Shi, J.; Naskar, S.; Briggs, N.; Roper, D. I.; A. Hermoso, J.; Sham, L.-T.; Luo, M.

10.1101/2024.01.16.575974 — microbiology — Posted on 2025-05-21

2167 Tracing the epistemic arc: Distinct physiological signatures for curiosity, insight, understanding and liking during interactions with visual art

Welke, D.; Vessel, E. A.

10.1101/2025.05.15.654230 — neuroscience — Posted on 2025-05-21

2168 The Role of Chloride Ions in Serotonin Transport

Huang, J.; Backer, A.; Uchendu, S.; Bekele, B.; Chen, Q.; Orabi, E.; Stix, R.; Zhang, Y.-W.; Rudnick, G.; Hellsberg, E.; Forrest, L. R.

10.1101/2025.05.20.654092 — biochemistry — Posted on 2025-05-20

2169 Behavioral Time Scale Synaptic Plasticity (BTSP) endows Hyperdimensional Computing with attractor features

Yu, C.; Wu, Y.; Wang, A.; Maass, W.

10.1101/2025.05.15.654220 — animal behavior and cognition — Posted on 2025-05-20

2170 Epstein-Barr virus and Helicobacter pylori Coinfection Drives Gut and Brain Barrier Dysfunction

Jha, H. C.; Saini, V.; Singh, S.; Baral, B.; Sinha, P.; Singh, A.; Gaudin, R.; Parmar, H. S.

10.1101/2025.05.20.655045 — microbiology — Posted on 2025-05-20

2171 Autonomous Retrieval for Continuous Learning in Associative Memory Networks

Saighi, P.; Marcelo, R.

10.1101/2025.05.15.654207 — neuroscience — Posted on 2025-05-20

2172 Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth

Shappell, H.; Liu, Z.; Khodaei, M.; He, G.; Gee, D.; Lindquist, M.; Sukhodolsky, D. G.; McCarthy, G.; Ibrahim, K.

10.1101/2025.05.15.654366 — neuroscience — Posted on 2025-05-20

2173 Can Pupillometry Reveal Perturbation Detection in Sensorimotor Adaptation during Grasping?

Pfalz, L.; Müller, C.; Kopiske, K.

10.1101/2025.05.15.654224 — neuroscience — Posted on 2025-05-20

2174 Age- and Sex-Related Differences in Sleep Patterns and Their Relations to Self-Reported Sleep and Mood

Eichi, H. R.; Baker, J. T.; Fjell, A. M.; Buckner, R. L.

10.1101/2025.05.15.654262 — neuroscience — Posted on 2025-05-20

2175 Decoding the epistemic arc: Distinct physiological signatures for curiosity, insight, understanding and liking during interactions with visual art

Welke, D.; Vessel, E. A.

10.1101/2025.05.15.654230 — neuroscience — Posted on 2025-05-20

2176 Rational Design and Modeling of Auxetic Fiber Scaffolds for Soft Tissue Engineering via Melt Electrowriting

Lecina-Tejero, O.; Iamsamang, J.; Alaman-Diez, P.; Garcia-Gareta, E.; Cuartero, J.; Perez, M. A.; Castilho, M.; Borau, C.

10.1101/2025.05.15.654200 — bioengineering — Posted on 2025-05-20

2177 CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment

Hu, W.-F.; Wang, J.-J.; Yu, J.; Liu, Y.-L.; Xu, Z.-G.; Guo, Z.-Y.

10.1101/2025.05.20.655027 — biochemistry — Posted on 2025-05-20

2178 Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.

Ito, H.; Machida, K.; Fujino, Y.; Hasumi, M.; Sakamoto, S.; Nagai, Y.; Imataka, H.; Taguchi, H.

10.1101/2025.05.19.654993 — biochemistry — Posted on 2025-05-20

2179 Importin α/β1 dependent nuclear import of Black Sea Bass Polyomavirus Large Tumor Antigen is mediated by a classical NLS located downstream of the SF3 helicase domain

Hoad, M.; Pavan, S.; Nematollahzadeh, S.; Tietz, O.; Reeman, J.; Forwood, J. K.; Alvisi, G.

10.1101/2025.05.20.655083 — microbiology — Posted on 2025-05-20

2180 Extensive richness and novel taxa of sulfoquinovose-degrading bacteria in the cow rumen

Krasenbrink, J.; Chen, S.-C.; Tanabe, T. S.; Sarikece, H.; Meurs, P.; Borusak, S.; Samrat, R.; Osvatic, J.; Seneca, J.; Hausmann, B.; Speth, D. R.; Selberherr, E.; Wanek, W.; Schleheck, D.; Mussmann, M.; Loy, A.

10.1101/2025.05.20.655074 — microbiology — Posted on 2025-05-20

2181 Virulence of Naegleria fowleri isolates varies significantly in the mouse model of primary amoebic meningoencephalitis

Russell, A. C.; Schiff, E. B.; Dainis, J.; Jones, H.; Rice, C. A.; Kyle, D. E.

10.1101/2025.05.20.655168 — microbiology — Posted on 2025-05-20

2182 Graphene Micro-transistor Arrays Reveal Perfusion-Dependent Electrophysiological and Haemodynamic Signatures of Cortical Spreading Depolarizations in Ischaemic Stroke

Flaherty, S. M.; Eladly, A.; Hills, K. E.; Merlini, J. E.; Masvidal-Codina, E.; Fernandez, E.; Illa, X.; Prats-Alfonso, E.; del Corro, E.; Garrido, J. A.; Kostarelos, K.; Allan, S. M.; Guimera-Brunet, A.; Wykes, R.

10.1101/2025.05.15.654197 — neuroscience — Posted on 2025-05-20

2183 Breathing strategies to influence perception: Evidence for interoceptive and exteroceptive active sensing

della Penna, F.; Zaccaro, A.; Bayram, B.; Bubbico, F.; Perrucci, M. G.; Costantini, M.; Ferri, F.

10.1101/2025.05.15.654033 — neuroscience — Posted on 2025-05-20

2184 A meta-analysis of effects of seaweed and other bromoform containing feed ingredients on methane production, yield, and intensity in cattle

Kebreab, E.; Pressman, E. M.; Ramirez-Agudelo, J. F.; Bannink, A.; van Gastelen, S.; Dijkstra, J.

10.1101/2025.05.17.654669 — systems biology — Posted on 2025-05-20

2185 Superinfections Shape Collective Lysis Dynamics in T-Even Phage Infections: Insights from an Individual-Based Model

Cabrera Cortada, J.; Mitarai, N.

10.1101/2025.05.16.654475 — systems biology — Posted on 2025-05-20

2186 A Reductive Uric Acid Degradation Pathway in Anaerobic Bacteria

Li, Z.; Meng, W.; Gao, Z.; Peng, W.; Zhang, J.; Wang, Y.; Wu, X.; Zhao, Z.; Zhang, C.; Tang, Z.; Nie, Z.; Wu, S.; Wu, B.; Tong, Y.; Hu, Y.; Hu, Z.; Wei, Y.; Zhang, Y.

10.1101/2025.05.19.654654 — biochemistry — Posted on 2025-05-20

2187 Specialized for the reach: Fruit picking and positional behavior favor a reach over a grasp phenotype for Geoffroy's spider monkey (Ateles geoffroyi )

Whishaw, I. Q.

10.1101/2025.05.15.654288 — animal behavior and cognition — Posted on 2025-05-20

2188 Validation of Duchenne muscular dystrophy candidate modifiers using a CRISPR-Cas9-based approach in zebrafish

Lerma, G.; Ryhlick, K. R.; Carraher, O. M.; Beljan, J. C.; Amacher, S. L.

10.1101/2025.05.20.655139 — genetics — Posted on 2025-05-20

2189 Fast and slow-paced reproductive life history across native and invasive populations of a predatory marine snail

Rugila, A.; Bucari, E.; Rawson, E.; Schlaug, A.; Komoroske, L. M.; Cheng, B. S.

10.1101/2025.05.15.654356 — ecology — Posted on 2025-05-20

2190 Exploring Spike-Dependent and ACE2-Independent Viral Entry into Salivary Epithelial Cells in the Absence of ACE2

Barrows, C. M. L.; Young, S.; Farach-Carson, M. C.

10.1101/2025.05.19.654917 — cell biology — Posted on 2025-05-20

2191 Ecological constraints and evolutionary trade-offs shape nitrogen fixation across habitats

Sobol, M.; Ane, C.; McMahon, K.; Kacar, B.

10.1101/2025.05.20.655134 — microbiology — Posted on 2025-05-20

2192 Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

Casas, A.; Imlay, L. S.; Thathy, V.; Deni, I.; Lehane, A. M.; Lawong, A. K.; Fairhurst, K. J.; Striepen, J.; Lee, S.; Kumar, A.; Xing, C.; Niederstrasser, H.; Posner, B. A.; Laleu, B.; Charman, S. A.; Fidock, D. A.; Ready, J. M.; Phillips, M. A.

10.1101/2025.05.20.655166 — microbiology — Posted on 2025-05-20

2193 Specialist Generalist Trade Offs in Microbial Growth Rates Across Soil Habitats

Foley, M.; Sokol, N.; Stone, B.; Blazewicz, S. J.; Estera-Molina, K.; Greenlon, A.; Hayer, M.; Kimbrel, J.; Pett-Ridge, J.; Hungate, B. A.

10.1101/2025.05.20.655198 — microbiology — Posted on 2025-05-20

2194 AGPAT1 is a novel Chikungunya virus receptor on human cells

Basu, B.; Sarmadhikari, D.; Asthana, S.; Kalia, M.; Vrati, S.

10.1101/2025.05.20.655106 — microbiology — Posted on 2025-05-20

2195 Chemical activity profiling reveals how exposure to drugs or dietary compounds alters gut microbial biotransformation capacity

Bigonne, H.; Zhai, S.; Folz, J.; Hurley, K.; Murali, A.; Zickgraf, F. M.; Kamp, H.; van Ravenzwaay, B.; Aichinger, G.; Sturla, S. J.

10.1101/2025.05.20.655107 — microbiology — Posted on 2025-05-20

2196 Sub-phenotypes of pneumonia defined by pulmonary histopathological features

Shastry, A.; Hiller, B. E.; Sanders, N. L.; Tseng, A. E.; Kothari, J.; O'Connell, A. K.; Gertje, H. P.; Ha, C. T.; Murzin, E.; Traber, K. E.; Lederer, J. A.; Jones, M. R.; Douam, F.; Beach, T. G.; Remick, D. G.; Crossland, N. A.; Monti, S.; Campbell, J. D.; Mizgerd, J. P.

10.1101/2025.05.18.654716 — immunology — Posted on 2025-05-20

2197 The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse

Sicorello, M.; Gianaros, P. J.; Wright, A. G. C.; Petre, B.; Kraynak, T.; Manuck, S.; Schmahl, C.; Wager, T. D.

10.1101/2025.05.15.653674 — neuroscience — Posted on 2025-05-20

2198 Evaluating the dependence of ADC-fMRI on haemodynamics inbreath-hold and resting-state conditions

de Riedmatten, I.; Spencer, A. P. C.; Nguyen-Duc, J.; Perot, J.-B.; Szczepankiewicz, F.; Esteban, O.; Jelescu, I. O.

10.1101/2025.05.15.654237 — neuroscience — Posted on 2025-05-20

2199 Targeted Neuromodulation of Perceptual Decision-Making Networks Causally Dissociates Sensory and Metacognitive performance

Di Luzio, P.; Tarasi, L.; Avenanti, A.; Silvanto, J.; Sel, A.; Romei, V.

10.1101/2025.05.15.653831 — neuroscience — Posted on 2025-05-20

2200 Aperiodic slope reflects glutamatergic tone in the human brain

Sheldon, A. A.; Moser, H. R.; Abdullahi, K. S.; Allison, K. D.; Mulder, C. B.; Montoya, S. A.; Sponheim, S. R.; Marjanska, M.; Schallmo, M.-P.

10.1101/2025.05.15.654118 — neuroscience — Posted on 2025-05-20

2201 Characterization of a novel glycocin from a thermophile

Martini, R. M.; van der Donk, W.

10.1101/2025.05.19.655019 — biochemistry — Posted on 2025-05-20

2202 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Amaral, M. L.; Mamde, S.; Miller, M.; Hou, X.; Arzavala, J.; Osteen, J.; Walker Smoot, E.; Yang, Q.; Eisner, E.; Zeng, Q.; Baez-Becerra, C. T.; Olness, J.; Kern, J. C.; Rink, J.; Johnson, N.; Barcoma, A.; Cho, S.; Cao, S.; Emerson, N.; Lee, J.; Willier, J.; Loe, T.; Jiao, H.; Zu, S.; Zhu, Q.; Preissl, S.; Wang, A.; Ecker, J.; Behrens, M. M.; Ren, B.

10.1101/2025.04.21.649585 — genomics — Posted on 2025-05-20

2203 Joint linear modeling of transcriptomics and proteomics reveals molecular coordination in cancer metastasis

Sharma, R.; Meimetis, N.; Begzati, A.; Nagar, S. D.; Kellman, B.; Baghdassarian, H. M.

10.1101/2025.02.15.638428 — systems biology — Posted on 2025-05-20

2204 Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET

Eggan, P.; Gordon, S. E.; Zagotta, W. N.

10.1101/2025.03.31.646362 — biophysics — Posted on 2025-05-20

2205 GPU-accelerated homology search with MMseqs2

Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.

10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-05-20

2206 Spatially Tuned Localization of Interleukins and OX40 Agonists EnhancesSynergistic Anti-Tumor Immunity

Klich, J.; Nejatfard, A.; Meany, E.; Ou, B. S.; Baillet, J.; Appel, E.

10.1101/2025.05.15.654266 — bioengineering — Posted on 2025-05-20

2207 Extracellular matrix viscoelasticity regulates mammary branching morphogenesis

Walter, D. I.; Moore, J. W.; Sharma, A.; Stowers, R.

10.1101/2025.05.15.654249 — bioengineering — Posted on 2025-05-20

2208 Improvement of human donor retinal ganglion cell survival through modulation of microglia

Malechka, V. V.; Phay, M. H.; Augustine, J.; Kriukov, E.; Rivera, J. D.; Alt, C.; Gregory-Ksander, M.; Baranov, P.

10.1101/2024.07.06.602307 — cell biology — Posted on 2025-05-20

2209 Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling

Guzman, S. D.; Abu-Mahfouz, A.; Davis, C. S.; Ruiz, L. P.; Macpherson, P. C.; Brooks, S. V.

10.1101/2023.10.06.561193 — neuroscience — Posted on 2025-05-20

2210 CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION

roullet, p.; Koehl, M.; Delage, P.; Guillemot, F.; Abrous, N.

10.1101/2025.05.15.654267 — neuroscience — Posted on 2025-05-20

2211 An unsupervised framework for comparing SARS-CoV-2 protein sequences using LLMs

Littlefield, S. B.; Campbell, R. H.

10.1101/2024.12.16.628708 — bioinformatics — Posted on 2025-05-20

2212 The NIH BRAIN Initiative Impacts in Systems and Computational Neuroscience and Team-Scale Research, 2014-2023

Bader, F.; Bingham, C.; David, K. K.; Gebrehiwet, H.; Lantz, C.; Peng, G. C. Y.; Rangel-Gomez, M.; Gnadt, J.

10.1101/2025.01.30.635684 — neuroscience — Posted on 2025-05-20

2213 Monitoring Circulating Cell-free HPV DNA in Metastatic and Recurrent Cervical Cancer: Clinical Importance and Implications for Treatment - A Pilot Study

Yin, Z.; Feng, T.; Xu, Q.; Dai, W.; Ni, M.; Ni, J.; Lou, H.

10.1101/2024.09.16.613189 — cancer biology — Posted on 2025-05-20

2214 Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke

Cottarelli, A.; Jamoul, D.; Tuohy, M. C.; Shahriar, S.; Glendinning, M.; Prochilo, G.; Edinger, A.; Arac, A.; Agalliu, D.

10.1101/2023.08.29.555373 — cell biology — Posted on 2025-05-20

2215 The long-term evolutionary potential of four yeast species and their hybrids in extreme temperature conditions

Pinto, J.; Stelkens, R.

10.1101/2024.09.27.615317 — evolutionary biology — Posted on 2025-05-20

2216 Efficient profiling of total RNA in single cells with STORM-seq

Johnson, B. K.; Majewski, M.; Jang, H. J.; Siwicki, R. A.; Wegener, M.; Semwal, A.; Morrison, J.; Gallik, K. L.; Hagemann-Jensen, M.; Foy, K.; Rossell, L. L.; Siegwald, E. J.; Chesla, D. W.; Teixeira, J. M.; Adams, M.; Drapkin, R.; Esquibel, C.; Sheridan, R. T. C.; Wang, T.; Sandberg, R.; Triche, T. J.; Shen, H.

10.1101/2022.03.14.484332 — molecular biology — Posted on 2025-05-20

2217 Sequence similarity estimation by random subsequence sketching

Chen, K.; Pattar, V.; Shao, M.

10.1101/2025.02.05.636706 — bioinformatics — Posted on 2025-05-20

2218 Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets

Hansen, M. S.; Hill, C. J.; Sussel, L.; Wells, K. L.

10.1101/2025.04.30.651101 — genomics — Posted on 2025-05-20

2219 Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature

Unitt, A.; Krisna, M. A.; Parfitt, K. M.; Jolley, K. A.; Maiden, M. C. J.; Harrison, O. B.

10.1101/2025.03.28.646058 — genomics — Posted on 2025-05-20

2220 Divergent paths, convergent heads: morphological adaptation of head shape to ecological niches in snakes.

Hudry, D.; Herrel, A.

10.1101/2025.05.17.654544 — evolutionary biology — Posted on 2025-05-20

2221 The Mediator Kinase Module regulates cell cycle re-entry and transcriptional responses following DNA damage

Memisoglu, G.; Bohn, S.; Krogan, N.; Haber, J. E.; Ruthenburg, A. J.

10.1101/2023.02.26.530133 — molecular biology — Posted on 2025-05-20

2222 Quantifying phage infectivity from characteristics of bacterial population dynamics

Blazanin, M.; Vasen, E.; Jolis, C. V.; An, W.; Turner, P.

10.1101/2023.06.29.546975 — microbiology — Posted on 2025-05-20

2223 A mechanism linking dopamine's roles in reinforcement, movement and motivation

Hamilos, A. E.; Wijsman, I. C.; Ding, Q.; Assawaphadungsit, P.; Ozcan, Z.; Norri, E.; Assad, J. A.

10.1101/2025.04.04.647288 — neuroscience — Posted on 2025-05-20

2224 Face-, color-, and word-specific patches in the human orbitofrontal cortex

Liu, J.; Cohen, L.; Zhan, M.; Bartolomeo, P.

10.1101/2025.04.22.650059 — neuroscience — Posted on 2025-05-20

2225 A common garden of Halichondria sponges: taxonomic revision of Northeast Pacific Halichondriidae reveals many cryptic introduced species

Turner, T. L.; Morrow, C.; Picton, B.; Goodwin, C.; Thacker, R. W.

10.1101/2024.11.04.621922 — zoology — Posted on 2025-05-20

2226 Illuminating Glucomannan Synthases to Explore Cell Wall Synthesis Bottlenecks

Griess-Osowski, A.; Robert, M.; Qiande, M.; Clauss, S.; Voiniciuc, C.

10.1101/2025.03.09.642175 — synthetic biology — Posted on 2025-05-20

2227 TNF-mediated myeloid-instructed CD14+CD4+ T cells within the tumor microenvironment are associated with poor survival in non-small cell lung cancer.

Marceaux, C.; Tarasova, I.; Batey, D.; Yokote, K.; Gayevskiy, V.; Jain, R.; Leiwe, M.; Choux, L.; Riley, L.; Tubau, N.; Hywood, J.; Christie, M.; Antippa, P.; Speed, T. P.; Rogers, K. L.; Phipson, B.; Asselin-Labat, M.-L.

10.1101/2024.08.02.606259 — cancer biology — Posted on 2025-05-20

2228 Cell type-specific functions of nucleic acid-binding proteins revealed by deep learning on co-expression networks

Osato, N.

10.1101/2025.03.03.641203 — bioinformatics — Posted on 2025-05-20

2229 mzLearn, a data-driven LC/MS signal detection algorithm, enables pre-trained generative models for enhanced patient stratification

Pirhaji, L.; Eaton, J.; Jeewajee, A. K.; Zhang, M.; Morris, M.; Karasarides, M.

10.1101/2025.01.26.634927 — bioinformatics — Posted on 2025-05-20

2230 Magnetic Resonance Imaging for Improved Brain Tumor Detection

Benyard, B. A.; Soni, N.; Swain, A.; Srivastava, N.; Khokhar, S.; Yehya, N.; Fan, Y.; Kumar, D.; Nanga, R. P. R.; Frenneaux, M. P.; Haris, M.; Reddy, R.

10.1101/2025.05.06.652446 — bioengineering — Posted on 2025-05-20

2231 Dissecting bioelectrical networks in photosynthetic membranes with electrochemistry

Lawrence, J. M.; Egan, R. M.; Wey, L. T.; Bali, K.; Chen, X.; Kosmützky, D.; Eyres, M.; Nan, L.; Wood, M. H.; Nowaczyk, M. M.; Howe, C. J.; Zhang, J. Z.

10.1101/2025.03.18.643929 — biochemistry — Posted on 2025-05-20

2232 A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation

Nguyen, V. C. B.; Özden, C.; Dong, K.; Koc, O.; Torres-Ocampo, A. P.; Dziedzic, N.; Flaherty, D.; Huang, J.; Sankura, S.; Abromson, N. L.; Tomchick, D. R.; Fissore, R. A.; Chen, J.; Garman, S. C.; Stratton, M.

10.1101/2024.03.24.586494 — biochemistry — Posted on 2025-05-20

2233 Disruption without diversity loss: how spreading thermotolerant Pilidium lythri infection perturbs plant-soil microbiome stability

Siegieda, D.; Panek, J.; Hannula, E. S.; Frac, M.

10.1101/2025.01.28.633866 — microbiology — Posted on 2025-05-20

2234 Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages

Khan, I.; MacDonald, S. J.; Markusson, S.; Kies, P. J.; Kraemer-Zimpel, C.; Robson, C.; Parker, J. L.; Newstead, S.; Boucher, D.; Hammer, N. D.; Van der Woude, M.; Thomas, G. H.

10.1101/2024.12.02.626324 — microbiology — Posted on 2025-05-20

2235 Investigating Factors Driving Shifts in Subtype Dominance within H5Nx Clade 2.3.4.4b High-Pathogenicity Avian Influenza viruses

Billington, E.; Di Genova, C.; Warren, C. J.; Thomas, S. S.; Johnson, S.; Riccio, S.; De Sliva, D.; Peers-Dent, J.; Temperton, N. J.; da Costa, K.; Byrne, A. M. P.; Airey, M.; Schlachter, A.-L.; Yang, J.; Nunez, A.; Iqbal, M.; Slomka, M. J.; Brown, I. H.; Banyard, A. C.; James, J.

10.1101/2025.04.23.650244 — microbiology — Posted on 2025-05-20

2236 Sex-dependent neural plasticity in response to damage

Recatala-Martinez, M.; Bosch, M.; Gaspar, P.; Mineo, A.; Rios, S.; Miguel-Aliaga, I.; Morey, M.

10.1101/2025.05.05.652027 — neuroscience — Posted on 2025-05-20

2237 Striatal Gradient in Value-Decay Explains Regional Differences in Dopamine Patterns and Reinforcement Learning Computations

Kato, A.; Morita, K.

10.1101/2025.01.24.631285 — neuroscience — Posted on 2025-05-20

2238 No facilitatory effects of transcranial random noise stimulation on motion processing: A registered report

Edwards, G.; Ruhde, R.; Carroll, M. B.; Baker, C. I.

10.1101/2025.03.18.643903 — neuroscience — Posted on 2025-05-20

2239 Beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual postural task

Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Szul, M. J.; Bonaiuto, J. J.; Bonnefond, M.; Schmitz, C.

10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-05-20

2240 Rapid Dopaminergic Signatures in Movement: Reach Vigor Reflects Reward Prediction Error and Learned Expectation

Korbisch, C. C.; Ahmed, A. A.

10.1101/2025.03.24.645035 — neuroscience — Posted on 2025-05-20

2241 Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.

CHIE, J. A. K. H. C.; PERSOHN, S. A.; PANDEY, R. S.; SIMCOX, O. R.; SALAMA, P.; TERRITO, P. R.

10.1101/2025.05.12.653558 — neuroscience — Posted on 2025-05-20

2242 miRNA synergism impaired metabolic programming of oral cancer cells by selectively enhancing target gene specificity

Mazumder, S.; Banerjee, U.; Sinsinwar, S.; Mandal, S.; Prusty, D.; Babele, P.; Das, B.; Manna, S. K.; Ray, J. G.; Chatterjee, R.

10.1101/2024.08.01.606174 — cancer biology — Posted on 2025-05-20

2243 A periplasmic metallochaperone of the Cation Diffusion Facilitator YiiP is required for Zn2+ sensing in Pseudomonas aeruginosaript

Mihelj, P.; Moreyra, T. E.; Carrizo, M. E.; Raimunda, D. C.

10.1101/2025.05.19.654957 — biochemistry — Posted on 2025-05-20

2244 Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis

Nissen, I.; Dakhel, S.; Chakraborty, C.; Nygaard, A. H.; Kirkeby, A.; Hornblad, A.; Erdem, C.; Remeseiro, S.

10.1101/2025.04.30.651564 — genomics — Posted on 2025-05-20

2245 Mast fruiting in a large tropical African legume tree provides evidence for the nutrient resource limitation hypothesis

Newbery, D. M.; Schwan, S.; Chuyong, G. B.; Neba, G. A.; Etta, C. E.; Norghauer, J. M.; Worbes, M.

10.1101/2023.04.03.535348 — ecology — Posted on 2025-05-20

2246 Temperature changes are signaled in cyanobacteria through the PipX interaction network

Llop, A.; Bibak, S.; Mata-Balaguer, T.; Tremino, L.; Fuertes-Garcia, L.; Neira, J. L.; Dixon, R.; Contreras, A.

10.1101/2025.05.19.654826 — molecular biology — Posted on 2025-05-20

2247 Increased excitation enhances the sound-induced flash illusion by impairing multisensory causal inference in the schizophrenia spectrum

Paredes, R.; Ferri, F.; Romei, V.; Series, P.

10.1101/2024.05.29.596551 — neuroscience — Posted on 2025-05-20

2248 An artefact-resilient wide bandwidth bidirectional graphene neural interface

Prokop, M.; Esparza-Iaizzo, M.; Masvidal-Codina, E.; Codadu, N. K.; Rathore, D.; Ria, N.; Kostarelos, K.; del Corro, E.; Garcia-Cortadella, R.; Wykes, R. C.; Guimera-Brunet, A.; Garrido, J. A.

10.1101/2025.05.15.653988 — neuroscience — Posted on 2025-05-20

2249 Neurocomputational Mechanisms Linking Future Interaction Prospects to Reactive and Proactive Costly Punishment

Feng, C.; Huang, C.; Zhou, X.; Liu, F.; Yang, B.; Zheng, Z.; Li, X.; Yin, Y.; Luo, Y.-J.

10.1101/2025.05.15.654171 — neuroscience — Posted on 2025-05-20

2250 Gender differences in submission behavior exacerbate publication disparities in elite journals

Ni, C.; Basson, I.; Badia, G.; Tufenkji, N.; Sugimoto, C. R.; Lariviere, V.

10.1101/2023.08.21.554192 — scientific communication and education — Posted on 2025-05-20

2251 So close yet so far apart: Distinct flanking sequence recognition by DNMT3A and DNMT3B

Barlas, A. B.; Karaca, E.

10.1101/2024.02.07.579311 — biophysics — Posted on 2025-05-20

2252 Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in M. tuberculosis clinical isolates

Ioerger, T. R.; Shatby, A.

10.1101/2025.05.07.652684 — bioinformatics — Posted on 2025-05-20

2253 Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Tang, E.; Hu, Y.; Cao, G.; Asby, N. W.; Nguyen, D.-T.; Aboelella, N. S.; Ruiz, H.; Zhao, Y.; Xie, L.; Chen, X.; Bishop, M. R.; Riedell, P. A.; LaBelle, J. L.; Kline, J. P.; Huang, J.

10.1101/2025.05.13.653878 — immunology — Posted on 2025-05-20

2254 Integration of past caspase activity biases cell elimination in vivo

Cumming, T.; Villars, A.; Davidovic, A.; Levillayer, F.; Valon, L.; Levayer, R.

10.1101/2025.05.18.654727 — developmental biology — Posted on 2025-05-20

2255 Pathogenicity of Commensal Gut Biofilm In Prefrail Aging

Le Cosquer, G.; Pannier, M.; Meunier, E. S.; Thevenin, J.; Pyhourquet, E.; Guyonnet, S.; Vellas, B.; Santin, Y.; Guiard, B.; Parini, A.; Buscail, L.; Bournet, B.; Guillemet, D.; Deraison, C.; Vergnolle, N.; Motta, J. P.

10.1101/2024.06.04.596782 — microbiology — Posted on 2025-05-20

2256 Two Axes of White Matter Development

Luo, A. C.; Meisler, S. L.; Sydnor, V. J.; Alexander-Bloch, A.; Bagautdinova, J.; Barch, D. M.; Bassett, D. S.; Davatzikos, C.; Franco, A. R.; Goldsmith, J.; Gur, R. E.; Gur, R. C.; Hu, F.; Jaskir, M.; Kiar, G.; Keller, A. S.; Larsen, B.; Mackey, A. P.; Milham, M. P.; Roalf, D. R.; Shafiei, G.; Shinohara, R. T.; Somerville, L. H.; Weinstein, S. M.; Yeatman, J. D.; Cieslak, M.; Rokem, A.; Satterthwaite, T. D.

10.1101/2025.03.19.644049 — neuroscience — Posted on 2025-05-20

2257 Identification of Sensory Fiber Types in Mouse Temporomandibular Joint Tissues

Alfaro, J. J.; Akopian, A. N.

10.1101/2025.05.15.654333 — neuroscience — Posted on 2025-05-20

2258 Evolution of a novel left-right asymmetry in organ size by co-option of a tissue rotation process

Lefevre, B. M.; Delvigne, M.; Camprodon, A.; Vidal, J.; Courtier-Orgogozo, V.; Lang, M.

10.1101/2022.01.16.476383 — evolutionary biology — Posted on 2025-05-20

2259 Evolutionary dynamics of gene and isoform regulation underlying rapid and parallel adaptive radiations

Singh, P.; Ahi, E. P.; Duenser, A.; Durdevic, M.; Gessl, W.; Schaeffer, S.; Seehausen, O.; Sturmbauer, C.

10.1101/2025.05.13.653813 — evolutionary biology — Posted on 2025-05-20

2260 Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

Ampartzidis, I.; Thompson, E. M.; Gupta, Y.; Krstevski, A.; Elvassore, N.; Maniou, E.; De Coppi, P.; Galea, G. L.

10.1101/2025.05.16.654453 — developmental biology — Posted on 2025-05-20

2261 Network-based Near-Scalp Personalized Brain Stimulation Targets

Kong, R.; Xue, A.; Ooi, L. Q. R.; Asplund, C.; Tan, X. W.; Goh, S. E.; Lee, J. J.; Koh, J. Z. J.; Tan, R. S. Y.; Singh, H. K. G.; Tan, T. W. K.; Webler, R. D.; Fox, M. D.; Siddiqi, S. H.; Tor, P.-C.; Yeo, B. T. T.

10.1101/2025.05.15.654391 — neuroscience — Posted on 2025-05-20

2262 The anti-cancer drug trametinib suppresses angiotensin-induced cardiac remodelling in mice but is detrimental to function

Cooper, S. T.; Duvenage, E.; Gattari, D.; Cull, J. J.; Dash, P. R.; Chan, D.; Soria, M. L.; Rossi, M.; Nasuto, S. J.; Holderbaum, W.; Kelion, A.; Sugden, P. H.; Glennon, P. E.; Clerk, A.

10.1101/2025.05.16.654397 — physiology — Posted on 2025-05-20

2263 Interpreting biochemical text with language models:a machine learning framework for reaction extraction and cheminformatic validation

Lim, D.; Badrinarayanan, S.; Sterling, K. C.; Rajesh, G.; Mistry, E.; Yang, D.; Lee, M.; Hsu, K. B.; Manjrekar, M.; Areff, C.; Xie, P.; Kristanto, I. A.; Chandran, A.; Anderson, J. C.

10.1101/2025.05.15.654376 — bioinformatics — Posted on 2025-05-20

2264 Rapid and accurate protein structure database search using inverse folding model and contrastive learning

Lyu, Q.; Wei, H.; Chen, S.; Peng, Z.; Yang, J.

10.1101/2025.05.15.654382 — bioinformatics — Posted on 2025-05-20

2265 Boring beetles and super models: mapping the distribution of a new invader

Coates, A.; Phillips, B. L.

10.1101/2025.05.15.654388 — ecology — Posted on 2025-05-20

2266 Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findings

Mahdy, A. K. H.; ElAbd, H.; Kokubun, E. E.; Kriukova, V.; Pesesky, M.; May, D. H.; Olbjorn, C.; Perminow, G.; Bengtson, M.-B.; Ricanek, P.; Andersen, S.; Detlie, T. E.; Kristensen, V. A.; Moum, B.; Vatn, M.; Bokemeyer, B.; Hov, J.; Halfvarsson, J.; Schreiber, S.; the IBSEN and IBSEN-III study group, ; Howie, B.; Robins, H. S.; Hoivik, M. L.; Franke, A.

10.1101/2025.05.16.654339 — immunology — Posted on 2025-05-20

2267 Complete360: A Multi-Omics Liquid Biopsy Platform with Attomole Sensitivity and High Reproducibility

Wang, Q.; Chaerkady, R.; Zhao, L.; Kashyap, A.; Fair, M.

10.1101/2025.05.16.654403 — systems biology — Posted on 2025-05-20

2268 Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body

Sun, Z.; Lih, T. M.; Hoang, T.; Chen, S.-Y.; Xu, J.; Lin, D. C.; Wang, Y.; Woo, J.; Huang, Y.; Chen, L.; Liu, H.; Alpern, M.; Milosevic, J.; He, H.-Z.; Chaerkady, R.; Wang, Q.; Zhang, H.

10.1101/2025.05.15.654311 — systems biology — Posted on 2025-05-20

2269 The blood-brain barrier regulates brain tumour growth specifically via the SLC36 amino acid transporter Pathetic in Drosophila

Dong, Q.; AlvarezOchoa, E.; Kosakamoto, H.; Obata, F.; Alexandre, C.; Cheng, L.

10.1101/2025.05.15.654179 — cancer biology — Posted on 2025-05-20

2270 Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation

Kwon, Y. Y.; Liang, Y.; Gomez-Jenkins, M.; Ahmed, M.; Jiang, G.; Hsiang, J.; Lewis, D.; Janowitz, T.; Goncalves, M. D.; White, E.; Hui, S.

10.1101/2025.05.15.654370 — cancer biology — Posted on 2025-05-20

2271 Machine Learning-Driven Drug Repurposing for KRAS G12C and KRAS G12D Inhibition

Fuschi, G.; Germain, J. S.; Bebensee, D.; Moawad, C.; Aladysheva, A.; Mohamed, A.; Elwakeel, E.; Brooks, B. R.; Amin, M.

10.1101/2025.05.16.654410 — cancer biology — Posted on 2025-05-20

2272 Benchmarking Spectral Library and Database Search Approaches for Metaproteomics Using a Ground-Truth Microbiome Dataset

Rajczewski, A. T.; Mehta, S.; Wagner, R.; Gabriel, W.; Johnson, J.; Do, K.; Vintila, S.; Wilhelm, M.; Kleiner, M.; Searle, B. C.; Griffin, T.; Jagtap, P.

10.1101/2025.05.15.654320 — bioinformatics — Posted on 2025-05-20

2273 Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs

Soldatkina, O.; Ventura-San Pedro, L.; El Hommad, A.; Ramirez, J. M.; Ripoll-Cladellas, A.; Sopena-Rios, M.; Ordi, J.; Pujol-Gualdo, N.; Mele, M.

10.1101/2025.05.16.654406 — genomics — Posted on 2025-05-20

2274 Interlocked transcription factor feedback loops maintain and restore touch sensation

Marques, F.; Chen, Y.; Destain, H.; Marinelli, M.; Kratsios, P.

10.1101/2025.05.15.654349 — developmental biology — Posted on 2025-05-20

2275 CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for embryonic cortical neural stem cell maintenance

Zheng, J.; Qi, S.; Wu, H.; Wu, J.; Chen, G.; Wang, H. J.; Pan, H.; Li, J.; Cheng, C.; Tang, K.; Lau, L. F.; Shen, Q.

10.1101/2025.05.16.654402 — developmental biology — Posted on 2025-05-20

2276 MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling.

MOSAIC Consortium, ; Hoffmann, C.

10.1101/2025.05.15.654189 — molecular biology — Posted on 2025-05-20

2277 Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human Studies

Rivas-Torrubia, M.; Morell, M.; Makowska, Z.; Kageyama, J.; Bosshard, A.; Lindblom, J.; Borghi, M. O.; Bettacchioli, E.; PRECISESADS flow cytometry consortium, ; PRECISESADS clinical consortium, ; Parodis, I.; Beretta, L.; Maranon, C.; Pers, J.-O.; Lesche, R.; McDonald, F.; Alarcon-Riquelme, M. E.; Barturen, G.

10.1101/2025.05.15.654304 — immunology — Posted on 2025-05-20

2278 Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury.

Kim, H. G.; Gauthier, M.-P. L.; Higgs, A.; Hernandez, D. A.; Zhou, M.; Brant, J. O.; Bacher, R. L.; Darden, D. B.; Wallet, S. M.; Mathews, C. E.; efron, P. A.; Kladde, M. P.; Maile, R.

10.1101/2025.05.15.654340 — immunology — Posted on 2025-05-20

2279 Early initiation of small intestine neuroendocrine tumors

Schiller, A.; Hultmark, A.; Lindberg, M.; Socratous, A.; Luijts, T.; Van den Eynden, J.; Elf, A.-K.; Rossi Norrlund, R.; Arvidsson, Y.; Elias, E.; Larsson, E.

10.1101/2025.05.16.654489 — cancer biology — Posted on 2025-05-20

2280 Medical Images as Biomarkers of Ageing - From Global and Local Patterns to Digital Twins

Mueller, T. T.; Starck, S.; Llalloshi, R.; Kaissis, G.; Ziller, A.; Rueckert, D.; Braren, R.

10.1101/2025.05.18.654705 — bioinformatics — Posted on 2025-05-20

2281 A high-quality draft genome assembly of the Neotropical butterfly, Batesia hypochlora (Nymphalidae: Biblidinae)

Pham, T. N.; Duplouy, A.; See, J.; Knowles, L. S.; Marquina, E.; Gallice, G. R.; Molleman, F.; Oostra, V.

10.1101/2025.05.17.654659 — genomics — Posted on 2025-05-20

2282 Modelling belowground plant acclimation to low soil nitrogen - An eco-evolutionary approach

Chakrawal, A.; Mooney, S. J.; Colombi, T.

10.1101/2025.05.16.653651 — ecology — Posted on 2025-05-20

2283 Matters arising: Forced Symmetry Artifacts in a Prohibitin Complex Structure

Herrmann, E.; Rose, K. M.; Hurley, J. H.

10.1101/2025.05.16.653159 — cell biology — Posted on 2025-05-20

2284 Predictive inference alterations in psychosis proneness are context-dependent

Tarasi, L.; Romei, V.

10.1101/2025.05.17.654666 — neuroscience — Posted on 2025-05-20

2285 Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model

Sun, G.; Lin, W.; Chen, R.; Jiang, L.; DeMott, M.; McShane, A.; Chan, M. C. K.; Ehrbar, D.; Zhang, X.; Begley, T.; Emili, A.; Wolozin, B.; Dedon, P.

10.1101/2025.05.15.654371 — neuroscience — Posted on 2025-05-20

2286 Repeated subconcussive head impacts compromise white matter integrity: A longitudinal DTI and NODDI study in collegiate football players

D'Amario, S.; Magee, B.; Champagne, A. A.; Wilson, M. E.; Ramirez-Garcia, G.; Coverdale, N. S.; Cook, D. J.

10.1101/2025.05.14.654080 — neuroscience — Posted on 2025-05-20

2287 An autonomous AI agent for universal behavior analysis

Aljovic, A.; Lin, Z.; Wang, W.; Zhang, X.; Marin-Llobet, A.; Liang, N.; Canales, B.; Lee, J.; Baek, J.; Liu, R.; Li, C.; Li, N.; Liu, J.

10.1101/2025.05.15.653585 — neuroscience — Posted on 2025-05-20

2288 eIF4G2-Mediated Translation Initiation of Histone Modifiers Is Essential for Intestinal Stem Cell Maintenance and Differentiation

Kunitomi, H.; Khaine, A. M.; Jamee, R.; Lancero, M.; Raychaudhuri, A.; Perli, S. D.; Sato, Y.; Iwasaki, M.; Ruivo, P. R.; Tomoda, K.; Mito, M.; Shichino, Y.; Iwasaki, S.; Yamanaka, S.

10.1101/2025.05.19.652834 — cell biology — Posted on 2025-05-20

2289 Assessing Large Language Model Alignment Towards Radio-logical Myths and Misconceptions

West, C.; Wang, Y.

10.1101/2025.05.16.652427 — bioinformatics — Posted on 2025-05-19

2290 Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

Schwaba, T.; Clapp Sullivan, M. L.; Akingbuwa, W. A.; Ilves, K.; Tanksley, P. T.; Williams, C. M.; Dragostinov, Y.; Liao, W.; Ackerman, L. S.; Fealy, J. C. M.; Hemani, G.; de la Fuente, J.; Gupta, P.; Stein, M. B.; Gelernter, J.; Levey, D. F.; Vosa, U.; Ausmees, L.; Realo, A.; Estonian Biobank Research Team, ; Vaht, M.; Allik, J.; Esko, T.; Mottus, R.; Vainik, U.; Jonsdottir, G. A.; Thorleifsson, G.; Gunnarsson, A. F.; Bjornsdottir, G.; Thorgeirsson, T. E.; Steffansson, H.; Stefansson, K.; Cheesman, R.; Qin, Q.; Corfield, E. C.; Ask, H.; Ask Torvik, F.; Ystrom, E.; Tesli, M.; Boomsma, D. I.;

10.1101/2025.05.16.648988 — genomics — Posted on 2025-05-20

2291 Low-coverage whole-genome sequencing facilitates accurate and cost-effective haplotype reconstruction in complex mouse crosses

Widmayer, S. J.; Wooldridge, L. K.; Swanzey, E.; Barter, M.; Snow, C.; Saul, M. C.; Meng, Q.; Dumont, B. L.; Reinholdt, L. G.; Gatti, D. M.

10.1101/2025.05.19.654056 — genetics — Posted on 2025-05-19

2292 Developmental evolution of social signals in the delayed plumage maturation of manakins (Aves: Pipridae)

Taylor, L. U.; Prum, R. O.

10.1101/2025.05.15.654367 — evolutionary biology — Posted on 2025-05-19

2293 An origin for a eukaryotic lipid transfer protein fold in Asgard archaea

Lipp, N.-F.; Budin, I.

10.1101/2025.05.16.653879 — evolutionary biology — Posted on 2025-05-20

2294 Spatiotemporal Models Reveal Dynamic Growth Patterns in U.S. West Coast Groundfish

Odell, A. N.; Marshall, K. N.; Ward, E. J.; Johnson, K. F.; Baskett, M. L.

10.1101/2025.05.19.653526 — ecology — Posted on 2025-05-19

2295 Quantifying the hydrological niche of swamp vegetation communities using indicator species

Deane, D. C.; Mason, T.; Krogh, M.; Cairns, J.; Keith, D.

10.1101/2025.05.18.653618 — ecology — Posted on 2025-05-19

2296 Effect of spatial overdispersion on confidence intervals for population density estimated by spatial capture-recapture

Efford, M. G.; Fletcher, D.

10.1101/2024.03.12.584742 — ecology — Posted on 2025-05-19

2297 Understudied and underprotected: biodiversity and conservation challenges in the Konkan region of Maharashtra

Chhaya, K.; Nulkar, G.; Bapat, P.; Barve, H.; Bhave, N.; Bokkasa, A.; Dandekar, V.; Desai, S.; Ghate, K.; Gindi, R.; Joglekar, A.; Joshi, A.; Joshi, P.; Kamat, S.; Karandikar, M.; Khod, C.; Kulkarni, M.; Lad, H.; Mandavkar, A.; Mestry, P.; Mishrikotkar, Y.; More, P.; Nerurkar, S.; Niphadkar, M.; Patwardhan, A.; Pawar, P.; Punjabi, G.; Purohit, P.; Rajwade, M.; Rane, M.; Raorane, V.; Surve, N.; Thakur, S.; Watve, A.; Naniwadekar, R.

10.1101/2025.05.16.653652 — ecology — Posted on 2025-05-20

2298 Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium

Mukherjee, A.; Hilzendeger, M.; Rinvelt, A.; Fatma, S.; Schupp, M.; Dalle Nogare, D.; Chitnis, A.

10.1101/2025.05.17.650326 — developmental biology — Posted on 2025-05-20

2299 Mutational landscape and molecular bases of echinocandin resistance

Durand, R.; Torbey, A. G.; Giguere, M.; Pageau, A.; Dube, A. K.; Lagüe, P.; Landry, C. R.

10.1101/2024.07.21.604487 — molecular biology — Posted on 2025-05-19

2300 Acquired Neutrophil Dysregulation in Systemic Lupus Erythematosus: A Central Role for Fc gamma Receptor Engagement

Huot, S.; Fortin, P. R.; Laflamme, C.; Tessier, P. A.; Pelletier, M.; Pouliot, M.

10.1101/2025.05.19.653336 — immunology — Posted on 2025-05-20

2301 Spatial Attention Weakly Modulates Visual Responses in the Lateral Geniculate Nucleus

Alitto, H. J.; Johnson, J. S.; Usrey, W. M.

10.1101/2025.05.16.652890 — neuroscience — Posted on 2025-05-19

2302 The superior colliculus arbitrates whole-brain dynamics for unconscious visual insight

Murata, T.; Kunishige, K.; Seno, S.; Ohzawa, I.; Kaneko, K.; Yanagida, T.; Haruno, M.; Hosoda, K.

10.1101/2025.04.09.648050 — neuroscience — Posted on 2025-05-19

2303 Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases

Wei, Z.; Chen, J.; Leapman, R. D.

10.1101/2025.05.16.653525 — systems biology — Posted on 2025-05-19

2304 MAGELLAN: Automated Generation of Interpretable Computational Models for Biological Reasoning

Clarke, M. A.; Barker, C. G.; Sun, Y.; Roumeliotis, T. I.; Choudhary, J. S.; Fisher, J.

10.1101/2025.05.16.653408 — systems biology — Posted on 2025-05-19

2305 Accelerating Natural Product Discovery with Linked MS-Genomics and Language/Transformer-Based Models

Tay, D. W. P.; Koh, W.; Ang, S. J.; Wong, Z. M.; Lim, Y. W.; Heng, E.; Yeo, N. Z. X.; Adaikkappan, K.; Wong, F. T.; Lim, Y. H.

10.1101/2025.01.20.633932 — synthetic biology — Posted on 2025-05-19

2306 Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.

Kelty, T. J.; Franczak, E.; Gay, N. R.; Many, G. M.; Sagendorf, T. J.; Sanford, J. A.; Hou, Z.; Gaul, D. A.; Fernandez, F.; Burant, C.; Hevener, A. L.; Adkins, J. N.; Bodine, S.; Lindholm, M. E.; Ortlund, E. A.; Schenk, S.; Thyfault, J. P.; Rector, R. S.; MoTrPAC Research Group,

10.1101/2025.05.16.652859 — physiology — Posted on 2025-05-19

2307 E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression

Valdivieso-Rivera, F.; Furino, V. O.; Leher, C. E.; Zanesco, A. M.; Cruz, M. K.; Gan, F. C.; Santoro, A. L.; Regina-Ferreira, L.; Santos, G. L.; Goncalves, T. T.; Leiria, L. O.; Moraes-Vieira, P. M.; Castilho, R. F.; Mori, M. A.; Velloso, L. A.; Sponton, C. H.

10.1101/2025.05.19.652826 — physiology — Posted on 2025-05-19

2308 AMPK activation prevents HCC development through inhibition of HNF4a activity

Sun, Z.; Linares, B.; Urdiales, C.; Alsarmi, F.; Putluri, N.; Van Nostrand, J. L.

10.1101/2025.05.16.652569 — cancer biology — Posted on 2025-05-19

2309 A Generalizable Tension Sensor Platform for Mechanotherapeutic Discovery

Pawlak, M. R.; Baldys, A.; McMahon, M. C.; Cichocki, F.; Gordon, W. R.

10.1101/2025.05.15.653325 — biophysics — Posted on 2025-05-19

2310 BroodScan: A Honeybee Brood Scanner Technology

Stefanec, M.; Hofstadler, D. N.; Kaercher, M. H.; Schmickl, T.

10.1101/2025.05.17.651227 — animal behavior and cognition — Posted on 2025-05-19

2311 Eurasian Spoonbill chicks receive parental care up to several months after fledging, but not into migration

Lok, T.; de Goeij, P.; Rakhimberdiev, E.; Piersma, T.; Vansteelant, W. M. G.

10.1101/2025.05.15.654226 — animal behavior and cognition — Posted on 2025-05-19

2312 Classification of Urticaceae based on morphology and phylogenetic inference

Monro, A. K.; Maurin, O.; Fu, L.-F.; Wells, T.; Wilmot-Dear, M.; Beentje, J.; Hind, N.; Friis, I.; Brewer, G.; Cowan, R.; Dodsworth, S.; Dong, J.; Epitawalage, N.; Sabino Kikuchi, I.; Larridon, I.; Moore, A.; Sauquet, H.; Ujetz, J.; Wei, Y.-G.; Wu, Z.-Y.; Forest, F.; Baker, W. J.; Gardner, E. M.

10.1101/2025.05.16.651835 — evolutionary biology — Posted on 2025-05-19

2313 The Extended Life Cycle: A Multiscale Modeling Framework for Extended Evolutionary Dynamics

Velez-Cruz, N.; Laubichler, M. D.

10.1101/2025.05.18.652243 — evolutionary biology — Posted on 2025-05-19

2314 Mutation rate estimate and population genomic analysis reveals decline of koalas prior to human arrival

Kovacs, T. G. L.; Foley, N. M.; Silver, L. W.; McLennan, E. A.; Hogg, C. J.; Ho, S. Y. W.

10.1101/2025.05.15.654135 — evolutionary biology — Posted on 2025-05-19

2315 Evidence-based guidelines for improving network detectability in rodent fMRI

Urosevic, M.; Desrosiers-Gregoire, G.; Fouquet, J. P.; Devenyi, G. A.; Gallino, D.; Yee, Y.; Chakravarty, M.

10.1101/2025.05.19.653309 — neuroscience — Posted on 2025-05-19

2316 De novo whole genome assembly of the globally invasive green shore crab Carcinus maenas (Linnaeus, 1758) via long-read Oxford Nanopore MinION sequencing

Brons, J. K.; Hackl, T.; Iacovelli, R.; Haslinger, K.; Lequime, S. J. J.; van der Meij, S. E. T.

10.1101/2025.05.19.654951 — genomics — Posted on 2025-05-19

2317 Optimizing phage-antibiotic combinations: impact of administration order against daptomycin non-susceptible (DNS) MRSA clinical isolates

Bleick, C.; Van Helden, S. R.; Berti, A. D.; Richa, R.; Lehman, S. M.; Bayer, A.; Rybak, M. J.

10.1101/2025.05.19.654851 — microbiology — Posted on 2025-05-19

2318 Multiscale analysis of myelin alterations in skin biopsies from synucleinopathies.

Di Fabrizio, M.; van der Gaag, B. L.; Terzi, M.; Aaron, E.; Steerenberg, N. B.; Bol, J. G.; van de Berg, W. D. J.; Stahlberg, H.; Lewis, A. J.

10.1101/2025.05.15.654285 — neuroscience — Posted on 2025-05-19

2319 The role of temporal sensitivity of synaptic plasticity in representation learning

Rubisch, P.; Stefan, M. I.; Hennig, M. H.

10.1101/2024.09.27.615415 — neuroscience — Posted on 2025-05-19

2320 Multiobjective learning and design of bacteriophage specificity

Novy, N.; Huss, P.; Evert, S.; Romero, P.; Raman, S.

10.1101/2025.05.19.654895 — synthetic biology — Posted on 2025-05-19

2321 Speed breeding transgenic American chestnut trees toward restoration

Klak, T.; Pilkey, H.; May, V. G.; Matthews, D.; Oakes, A. D.; Tan, E. H.; Newhouse, A. E.

10.1101/2025.05.19.654928 — plant biology — Posted on 2025-05-19

2322 STT3A is required for recognition of pathogen-derived sphingolipids in Arabidopsis

Choi, S.; Shimizu, M.; Abe, A.; Ishihama, N.; Ishikawa, Y.; Takemoto, D.; Shirasu, K.; Takano, Y.; Terauchi, R.; Kato, H.

10.1101/2025.05.18.654772 — plant biology — Posted on 2025-05-19

2323 Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen

Widjaja, V.; D'Orazio, S. M.; Das, P.; Takeda, X.; Rajendran, D. T.; Shi, Y.; Varghese, I.; Lam, Y.; Wang, J.; Batista, V. S.; Bhandari, V.; Lisi, G. P.

10.1101/2025.05.15.654344 — biophysics — Posted on 2025-05-19

2324 Multiscale Segmentation using Hierarchical Phase-contrast Tomography and Deep Learning

Zhou, Y.; Aslani, S.; Javanmardi, Y.; Brunet, J.; Standsby, D.; Carroll, S.; Bellier, A.; Ackermann, M.; Tafforeau, P.; Lee, P. D.; Walsh, C. L.

10.1101/2025.05.15.654263 — bioinformatics — Posted on 2025-05-19

2325 Triad-LMF: A Hierarchical Low-Rank Multimodal Fusion Framework for Robust Cancer Subtype Classification Using Multi-Omics Data

Tan, X.; Chen, X.; Ren, Z.; Tian, R.; Jiang, M.; Yang, D.; Guo, X.

10.1101/2025.05.15.653805 — bioinformatics — Posted on 2025-05-19

2326 Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen

McCool, R. S.; Acreman, C. M.; Powell, A. E.; Picucci, S. I.; Stieh, D. J.; Huynh, J.; Caruso, H.; Park, S.; O'Rear, J.; Chen, J.-L.; Palanski, B. A.; Byrne, P. O.; Sponholtz, M. R.; Chou, C.-W.; Kim, J.; Ledgerwood, J. E.; Weidenbacher, P. A.- B.; McLellan, J. S.

10.1101/2025.05.19.654955 — biochemistry — Posted on 2025-05-19

2327 Puzzling parasitic plants: phylogenetics and classification of Santalales revisited

Cauz-Santos, L. A.; Byng, J. W.; Chase, M. W.; Christenhusz, M. J. M.

10.1101/2025.05.16.654241 — evolutionary biology — Posted on 2025-05-19

2328 Grass Rhizome Proteomics Reveals Convergent Freezing-Tolerance Strategies

Oren, E.; Zhai, J.; Rooney, T. E.; Angelovici, R.; Hale, C. O.; Brindisi, L. J.; Hsu, S.-K.; Gault, C. M.; Hua, J.; La, T.; Lepak, N.; Fu, Q.; Buckler, E. S.; Romay, M. C.

10.1101/2025.05.15.654294 — evolutionary biology — Posted on 2025-05-19

2329 A domestication change at PvMYB26 in common bean sheds light on the origins of Middle American agriculture

Celebioglu, B.; Roy, J.; Farmer, A.; English, S.; Yu, X.; Xu, X.; McClean, P. E.; Gepts, P.; Parker, T.

10.1101/2025.05.15.654381 — evolutionary biology — Posted on 2025-05-19

2330 Using wingbeat frequency to estimate mass gained by seabirds

Patterson, A.; Auger-Methe, M.; Elliott, K.

10.1101/2025.05.15.654001 — ecology — Posted on 2025-05-19

2331 Annotating opportunistic camera-trap images with conditions ofrecording, for the disease surveillance of Eurasian lynx (Lynxlynx)

Blin, L.; Decors, A.; Chenesseau, D.; Lenglin, L.; Ryser-Degiorgis, M.-P.; Zimmermann, F.; Borel, S.; Bastian, S.

10.1101/2025.05.15.654015 — ecology — Posted on 2025-05-19

2332 Heterogeneous NF-κB activation and enhancer features shape transcription in Drosophila immunity

Nawar, N.; Rits, E.; Cohen, L.; Wunderlich, Z.

10.1101/2025.05.19.654881 — molecular biology — Posted on 2025-05-19

2333 p53 status determines the epigenetic response to demethylating agents Azacitidine and Decitabine.

Hands, E. L.; Wallmann, A.; Oxley, G.; Storrar, S.; D'Souza, R.; Van de Pette, M.

10.1101/2025.05.19.654807 — molecular biology — Posted on 2025-05-19

2334 Candida auris Metabolism and Growth Preferences in Physiologically Relevant Skin-like Conditions

Nicklas, J. P.; Deming, C.; Lee-Lin, S.-Q.; Conlan, S.; Shen, Z.; Blaustein, R.; Segre, J. A.

10.1101/2025.05.18.654780 — microbiology — Posted on 2025-05-19

2335 Divergent MIC of Clarithromycin and Azithromycin Against Clinical Isolates of Mycobacterium abscessus Complex

Xu, P.; Cao, D.; Xiang, Y.; Dong, X.; Jiang, X.; Ji, Z.; Li, Y.; Yuan, X.; Qiu, Y.; Bi, K.; Zhang, Y.; Han, Y.; Xu, K.; Zhang, Y.

10.1101/2025.05.19.654969 — microbiology — Posted on 2025-05-19

2336 Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill

Reed, M.; Mennigen, J. A.; Jonz, M. G.

10.1101/2025.05.15.654070 — neuroscience — Posted on 2025-05-19

2337 The Cell Wall Controls Stem Cell Fate in the Arabidopsis Shoot Apical Meristem

Zerin, T.; Ruiz-Duarte, P.; Schuerholz, A.-K.; Prevedel, R.; Bevilacqua, C.; Ma, Y.; Schlamp, T.; Wenzl, C.; El Arbi, N.; Miotk, A.; Greb, T.; Lohmann, J. U.; Wolf, S.

10.1101/2025.05.19.654883 — plant biology — Posted on 2025-05-19

2338 Physiological characterization in a somaclonal mutant for fruit shape derived from persimmon 'Hiratanenashi'

Horiuchi, A.; Matsuzaki, R.; Onoue, N.; Ushijima, K.; Kubo, Y.; Akagi, T.; Minamikawa, M. F.

10.1101/2025.05.19.654774 — plant biology — Posted on 2025-05-19

2339 Identifying and quantifying the disease responses of different pennycress accessions to Alternaria japonica and Sclerotinia sclerotiorum

Kujur, A.; Codjoe, J. M.; Shah, D. M.; Chopra, R.

10.1101/2025.05.15.654111 — pathology — Posted on 2025-05-19

2340 Synergistic Effect of Thermoneutral Housing and Chronotherapeutic PD-1 Blockade Overcomes Melanoma Resistance

Tang, J.; Miller, J.; Yang, R.

10.1101/2025.05.15.654271 — cancer biology — Posted on 2025-05-19

2341 BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments

Dincer, C.; Fussing, B.; Garnett, M.; Coelho, M. A.

10.1101/2025.05.19.654892 — bioinformatics — Posted on 2025-05-19

2342 Fast, flexible gene cluster family delineation with IGUA

Larralde, M.; Blom, J.; Gourle, H.; Carroll, L. M.; Zeller, G. M.

10.1101/2025.05.15.654203 — bioinformatics — Posted on 2025-05-19

2343 Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPs

Pan, Y.; Zhong, Y.; Chen, H.; Zhang, Y.; Dai, Z.; Chen, J.; Tan, K.; Chen, X.; Qiu, D.; Sheng, L.; Tan, X.; Fan, Y.; Bu, Y.; Zhou, Z.; Yang, Z.; Duan, R.; Guan, M.; Gao, G.; Li, H.

10.1101/2025.05.19.654800 — bioengineering — Posted on 2025-05-19

2344 Explainable AI-Driven Diagnosis Model for Early Glaucoma Detection Using Grey-Wolf Optimized Extreme Learning Machine Approach

Muduli, D.; Sharma, S. K.; Dash, S.; Lemos, B.; Mallik, S.

10.1101/2025.05.15.654213 — bioengineering — Posted on 2025-05-19

2345 Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Castillo, L. F.; Heyden, K. E.; Williamson, A. R.; Ma, W.; Malysheva, O. V.; Vacanti, N. M.; Thalacker-Mercer, A. E.; Field, M. S.

10.1101/2025.05.19.654973 — biochemistry — Posted on 2025-05-19

2346 Assessing the population genetic structure and demographic history of Anopheles gambiae and Anopheles arabiensis at island and mainland populations in Uganda: Implications for testing novel malaria vector control approaches.

Mwima, R.; Hui, T.-Y. J.; Lukyamuzi, E.; Bodde, M.; Makunin, A.; Birungi, K.; Lukindu, M.; Nanteza, A.; Muhanguzi, D.; Lawniczak, M.; Burt, A.; Kayondo, J.

10.1101/2025.05.19.654785 — evolutionary biology — Posted on 2025-05-19

2347 Emergent coexistence and the limits of reductionism in ecological communities

Aguade-Gorgorio, G.; Kefi, S.

10.1101/2025.05.15.654235 — ecology — Posted on 2025-05-19

2348 Population dynamics of generalist/specialist strategies in the feast-famine cycle

Niimi, R.; Furusawa, C.; Himeoka, Y.

10.1101/2025.05.15.654191 — ecology — Posted on 2025-05-19

2349 An aphid-resistant plant metabolite as a candidate aphicide: Insight into the bioactivity and action mode of betulin against aphids

Wang, J.; Klakong, M.; Zhu, Q.; Pan, J.; Duan, Y.; Wang, L.; Li, Y.; Dang, J.; Jing, D.; Zhou, H.

10.1101/2025.05.18.654759 — molecular biology — Posted on 2025-05-19

2350 The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid

Kleinpeter, A. B.; Mallery, D. L.; Anna, A.; Burdick, R. C.; Renner, N.; Klarhof, J. O.; Vamos, B.; Pathak, V. K.; James, L. C.; Freed, E. O.

10.1101/2025.05.19.654868 — microbiology — Posted on 2025-05-19

2351 Temperature-dependent modulation of aberrant influenza A virus RNA synthesis affects innate immune signaling

Bisht, K.; Weilandt, D.; Lamb, C.; Elshina, E.; Myhrvold, C.; te Velthuis, A. J. W.

10.1101/2025.05.19.654939 — microbiology — Posted on 2025-05-19

2352 The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in ApcMin/+ mice

Hamidi Nia, L.; Alqudah, S.; Markley, R. L.; DeLucia, B.; Bobba, V.; Elmallah, J.; Nemet, I.; Sangwan, N.; Claesen, J.

10.1101/2025.05.18.654755 — microbiology — Posted on 2025-05-19

2353 Evasion of CARD8 Activation During HIV-1 Assembly

Hughes, I. K.; Hood, J. B.; Quinones-Molina, A.; Akiyama, H.; Gummuluru, S.

10.1101/2025.05.19.654850 — microbiology — Posted on 2025-05-19

2354 TRIM28 is a target for paramyxovirus V proteins

Lieber, G.; Lork, M.; Schmidt, N.; Hale, B. G.

10.1101/2025.05.19.654852 — microbiology — Posted on 2025-05-19

2355 Condensation of the RNA chaperone Hfq is coupled to inhibition of carbon assimilation and contributes to the stabilisation of regulatory RNAs in nitrogen starved Escherichia coli

McQuail, J.; Ellis, H.; Behrends, V.; Nadal, C.; Bischler, T.; Graefenhan, T.; Wigneshweraraj, R.

10.1101/2025.05.19.654817 — microbiology — Posted on 2025-05-19

2356 T cell memory alters pulmonary inflammatory responses to cecal ligation and puncture.

Brewer, M. R.; Deutschman, C. S.; Taylor, M. D.

10.1101/2025.05.15.654338 — immunology — Posted on 2025-05-19

2357 Dynamic fusion of structural and functional connectivity via joint connectivity matrix ICA

Wu, L.; Duda, M.; Iraji, A.; Calhoun, V.

10.1101/2025.05.15.653851 — neuroscience — Posted on 2025-05-19

2358 An organotrophic Sideroxydans reveals potential iron oxidation marker genes

Hoover, R. L.; Kuesel, K.; Chan, C. S.

10.1101/2025.02.27.639646 — microbiology — Posted on 2025-05-19

2359 Dynamic facial trustworthiness perception in real-time social contexts

Qi, H.; He, D.

10.1101/2024.08.19.608645 — neuroscience — Posted on 2025-05-19

2360 Social Experience Shapes Fighting Strategies for Reproductive Success

Gao, C.; Ma, M.; Chen, J.; Ji, X.; Peng, Q.; Pan, Y.

10.1101/2024.10.25.620166 — neuroscience — Posted on 2025-05-19

2361 The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma

Tharp, M. E.; Han, C. Z.; Talukdar, M.; Balak, C. D.; Fitzpatrick, C.; O'Connor, C.; Preissl, S.; Buchanan, J.; Nott, A.; Escoubet, L.; Mavrommatis, K.; Gupta, M.; Schwartz, M. S.; U, H. S.; Jones, P. S.; Levy, M. L.; Gonda, D. D.; Ben-Haim, S.; Ciacci, J.; Barba, D.; Khalessi, A.; Coufal, N. G.; Chen, C. C.; Glass, C. K.; Page, D. C.

10.1101/2024.06.06.597433 — genomics — Posted on 2025-05-19

2362 Targeted degradation of Drosophila FOG homolog U-shaped mimics macrophage transdifferentiation in S2 cells

Trummel, D.; Lenz, J.; Milani, W.; Joost, L. S.; tom Dieck, L. N.; Bogdan, S.; Brehm, A.

10.1101/2025.05.19.654861 — cell biology — Posted on 2025-05-19

2363 Antibiotic Resistance in Staphylococcus aureus: Effects of Quorum Sensing Inhibition and DNA Fragmentation

Kurup, S. S.; Taylor, P. K.; Adams, P. J.; Assogba, B. D.

10.1101/2025.04.26.649666 — microbiology — Posted on 2025-05-19

2364 Non-redundant cardiolipin synthases shape membrane composition and support stress resilience in Bacteroides fragilis

Schnizlein, M. K.; Hong, B.; Nguyen, J. N. T.; Jones, K.; Rodriguez, A. I.; Fiebig, A.; Campagna, S. R.; Balunas, M. J.; O'Halloran, T. V.; Crosson, S.

10.1101/2025.05.12.653583 — microbiology — Posted on 2025-05-19

2365 Higher-level spatial prediction in natural vision across mouse visual cortex

Heilbron, M.; de Lange, F. P.

10.1101/2025.05.15.654212 — neuroscience — Posted on 2025-05-19

2366 Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

Chowdhury, B.; Zhu, K.; Li, C.; Luebeck, J.; Chapman, O. S.; Kraft, K.; Zhang, S.; Chavez, L.; Henssen, A. G.; Mischel, P. S.; Chang, H.; Bafna, V.

10.1101/2025.02.01.636064 — cancer biology — Posted on 2025-05-19

2367 Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection

Mukherjee, R.; Bhattacharya, A.; Tomaskovic, I.; Mello-Vieira, J.; Brunstein, M. E.; Basoglu, M.; Veenendaal, T.; Bailey, H.; Colby, T.; Misra, M.; Eimer, S.; Klumperman, J.; Munch, C.; Matic, I.; Dikic, I.

10.1101/2025.05.19.654886 — cell biology — Posted on 2025-05-19

2368 ASPPs multimerize protein phosphatase 1

Wei, D. T.; Morrison, K. N.; Beacham, G. M.; Beyrent, E.; Zhang, Y.; Florens, L.; Hollopeter, G.

10.1101/2025.05.16.654433 — cell biology — Posted on 2025-05-19

2369 Dynamic hyperplastic cardiac growth in Burmese pythons

Tan, Y.; Martin, T. G.; Peter, A.; Ozeroff, C. D.; Ebmeier, C. C.; Doptis, R.; Harrison, B.; Leinwand, L.

10.1101/2025.05.19.654898 — cell biology — Posted on 2025-05-19

2370 Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Schoenfeld, J.; Liebisch, N.; Brunst, S.; Weizel, L.; Knapp, S.; Kannt, A.; Proschak, E.; Hiesinger, K.

10.1101/2025.05.19.654949 — cell biology — Posted on 2025-05-19

2371 Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism

Wan, X.; Ohkura, H.

10.1101/2025.05.19.654801 — cell biology — Posted on 2025-05-19

2372 Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells

Wu, T.; Li, Y.; Shi, L. Z.; Wu, X.

10.1101/2024.06.29.601361 — molecular biology — Posted on 2025-05-19

2373 When is microbial cross-feeding evolutionarily stable?

Lopez, J. A.; Liu, B.; Li, Z.; Donia, M. S.; Wingreen, N. S.

10.1101/2025.05.16.654511 — microbiology — Posted on 2025-05-19

2374 UTX Coordinates TCF1 and STAT3 to Control Progenitor CD8+ T cell Fate in Autoimmune Diabetes

Chen, H.-C.; Wang, H. H.; Shpargel, K. B.; Kohn, L. A.; Sailer, D.; Zhang, S.; McCarthy, E. C.; Seyedsadr, M.; Zhou, Z.; Yin, X.; Wilkinson, N. M.; Peluso, E.; Bustillos, C.; Ortega, J.; Yang, L.; Buzzelli, A. A.; Whitmire, J. K.; Lechner, M. G.; Hugo, W.; Su, M. A.

10.1101/2024.12.12.628206 — immunology — Posted on 2025-05-19

2375 Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum

Stanley, A. T.; Choi, S. J.; Frank, A.; Makowicz, E.; Cataldi, S.; Shashaank, N.; Mosharov, E. V.; Lacefield, C.; Miniaci, M.; Sulzer, D.

10.1101/2025.04.29.651089 — neuroscience — Posted on 2025-05-19

2376 Beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual postural task

Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Szul, M. J.; Bonaiuto, J. J.; Bonnefond, M.; Schmitz, C.

10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-05-19

2377 CABaNe, an automated, high content ImageJ macro for cell and neurite analysis

Thibieroz, N.; Cordelieres, F.; Machillot, P.; Marchadier, L.; Singh, A.; Picart, C.; Migliorini, E.

10.1101/2025.03.07.641590 — neuroscience — Posted on 2025-05-19

2378 Flexible computation of object motion and depth based on viewing geometry inferred from optic flow

Xu, Z.-X.; Pang, J.; Anzai, A.; DeAngelis, G. C.

10.1101/2024.10.29.620928 — neuroscience — Posted on 2025-05-19

2379 Information about task duration influences energetic cost during split-belt adaptation and retention of walking patterns post-adaptation

Jeffcoat, S.; Aragon, A.; Kuch, A.; Farrokhi, S.; Hooyman, A.; Johnson, R. T.; Sanchez, N.

10.1101/2024.05.24.595558 — neuroscience — Posted on 2025-05-19

2380 Medial olivocochlear efferent modulation of cochlear micromechanics requires P2X4 expression in outer hair cells

Riffaut, C.; Condamine, S.; Bouleau, Y.; Boue-Grabot, E.; Dulon, D.

10.1101/2025.05.15.654229 — neuroscience — Posted on 2025-05-19

2381 Amyloid-beta deposition and reduced drainage at the cribriform plate lymphatics in APP/PS1 mouse model of Alzheimer's Disease

Vrba, S. M.; Laaker, C. J.; Limkar, A. R.; Hsu, M.; Ricke, W. A.; Ulland, T. K.; Pehar, M.; Sandor, M.; Fabry, Z.

10.1101/2025.05.15.654007 — neuroscience — Posted on 2025-05-19

2382 Hematopoietic proliferation is orchestrated by the sequential and lineage-specific activation of Cyclin D, Cyclin E and CDKN sub-modules within the G1/S network

Hanel, A.; Abdelsalam, A.; Tollis, S.

10.1101/2025.05.15.654268 — systems biology — Posted on 2025-05-19

2383 TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

Rudzitis, C. N.; Lakk, M.; Singh, A.; Redmon, S. N.; Kirdajova, D.; Tseng, Y.-T.; deIeso, M. L.; Stamer, D.; Herberg, S.; Krizaj, D.

10.1101/2024.11.05.622187 — physiology — Posted on 2025-05-19

2384 SVCROWS: A User-Defined Tool for Interpreting Significant Structural Variants in Heterogeneous Datasets

Brown, N. J.; Danis, C.; Ahmedjonova, V.; Guler, J. L.

10.1101/2025.01.24.634734 — bioinformatics — Posted on 2025-05-19

2385 Structural basis for Porcupine inhibition

Black, K. A.; Mobbs, J. I.; Venugopal, H.; Dite, T. A.; Leis, A.; Wong, L. L.; Dagley, L.; Thal, D. M.; Glukhova, A.

10.1101/2025.05.19.654776 — biochemistry — Posted on 2025-05-19

2386 A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5

Yamashita, T.; Asamoto, K.; Fujii, K.; Fujiyabu, C.; Ohuchi, H.; Shichida, Y.

10.1101/2025.05.19.654871 — biochemistry — Posted on 2025-05-19

2387 Molecular determinants of extracellular TIMP-3 accumulation in Sorsby fundus dystrophy.

Betts, J. H.; Hampton, K.; Strickland, D. K.; Clark, S. J.; Day, A. J.; Troeberg, L.

10.1101/2025.05.19.654781 — biochemistry — Posted on 2025-05-19

2388 Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells

Nemkov, T.; Stauffer, E.; Cendali, F.; Stephenson, D.; Nader, E.; Robert, M.; Skinner, S.; Dzieciatkowska, M.; Hansen, K. C.; Robach, P.; Millet, G. Y.; Connes, P.; D'Alessandro, A.

10.1101/2025.04.09.648006 — biochemistry — Posted on 2025-05-19

2389 Backbone Assignment of a 28.5 kDa Class A Extended Spectrum β-Lactamase by High-Field, Carbon-Detected Solid-State NMR

Williams, C. G.; Wang, S.; Thome, A. F.; Warmuth, O. A.; Sakhrani, V.; Rienstra, C. M.; Mueller, L. J.

10.1101/2025.05.18.654753 — biochemistry — Posted on 2025-05-19

2390 ADAM-tRNA-seq: An Optimized Approach for Demultiplexing and Enhanced Hierarchal Mapping in Direct tRNA Sequencing

Alarcon, R.; Koester, D.; Behrmann, S.; Ignatova, Z.

10.1101/2025.05.19.654926 — biochemistry — Posted on 2025-05-19

2391 Exploring the interplay of complex carbohydrate intake, the microbiome CAZymes pool and short-chain fatty acid production in the human gut: insights from different cohorts in the Argentine population

Trotta, M.; Agustini, C.; Rohr, C.; Ame, R. M.; Giordano, L.; Balderramo, D.; Romagnoli, P.; Vazquez, M. P.

10.1101/2025.05.15.654276 — genomics — Posted on 2025-05-19

2392 Efficient Estimation of Nucleotide Diversity and Divergence using Depth Information

Mirchandani, C. D.; Enbody, E.; Sackton, T. B.; Corbett-Detig, R.

10.1101/2025.05.15.654353 — genomics — Posted on 2025-05-19

2393 Oncogenic lncRNA transgene transcription modulates epigenetic memory at a naive chromosomal locus.

Sikder, S.; Baek, S.; Dalal, Y.; Arunkumar, G.

10.1101/2025.05.15.654293 — genetics — Posted on 2025-05-19

2394 Macroevolutionary Rates of Species Interactions: Approximate Bayesian Inference from Cophylogenies

Zeng, Y.; Roman-Palacios, C.

10.1101/2025.05.15.653894 — evolutionary biology — Posted on 2025-05-19

2395 Interaction between long-range chromatin regulators Nipbl & Isl1 synergistically drives heart defects in mice

Chea, S.; Santos, R.; Lopez-Burks, M. E.; Lander, A.; Calof, A.

10.1101/2025.05.15.654123 — developmental biology — Posted on 2025-05-19

2396 SIRT1 limits neuronal fate following DNA damage

Kroll, C.; Karacora, B.; Meuth, S.; Fritz, G.; Aktas, O.; Berndt, C.; Prozorovski, T.

10.1101/2025.05.19.654885 — cell biology — Posted on 2025-05-19

2397 The Molecular Logic of Gtr1/2 and Pib2 Dependent TORC1 Regulation in Budding Yeast

Cecil, J. H.; Padilla, C. M.; Lipinski, A. A.; Langlais, P.; Luo, X.; Capaldi, A. P.

10.1101/2023.12.06.570342 — molecular biology — Posted on 2025-05-19

2398 Do Existing COVID-19 Vaccines Need to Be Updated in 2025?

Mellis, I. A.; Wu, M.; Wang, Q.; Bowen, A.; Gherasim, C.; Pierce, V. M.; Shah, J. G.; Purpura, L. J.; Yin, M. T.; Gordon, A.; Guo, Y.; Ho, D. D.

10.1101/2025.05.02.651777 — microbiology — Posted on 2025-05-19

2399 DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity

Li, L.; Huang, H.; Wang, H.; Pan, Y.; Tao, H.; Zhang, S.; Karmaus, P.; Fessler, M. B.; Sleasman, J.; Zhong, X.-P.

10.1101/2024.11.26.625360 — immunology — Posted on 2025-05-19

2400 Thrifty wide-context models of B cell receptor somatic hypermutation

Sung, K.; Johnson, M. M.; Dumm, W.; Simon, N.; Haddox, H.; Fukuyama, J.; Matsen, F. A.

10.1101/2024.11.26.625407 — immunology — Posted on 2025-05-19

2401 Jchain-Diphtheria Toxin Receptor Mice Allow for Diphtheria Toxin-Mediated Depletion of Antibody-Secreting Cells and Analysis of Differentiation Kinetics

Pioli, K. T.; Ritchie, M.; Haq, H.; Pioli, P. D.

10.1101/2024.05.06.592703 — immunology — Posted on 2025-05-19

2402 Modulation of cofilin 1 phosphorylation induces juvenile-like plasticity in the adult mouse visual cortex.

Dapueto, A.; Hayek, E.; Acunha, A.; Pannunzio, B.; Gomez, L.; Rossi, F. M.

10.1101/2025.05.05.652250 — neuroscience — Posted on 2025-05-19

2403 Intrinsic fluctuations in global connectivity reflect transitions between states of high and low prediction error

Bogdan, P. C.; Huang, S. C.; Deng, L.; Davis, S. W.; Cabeza, R.

10.1101/2025.03.18.643969 — neuroscience — Posted on 2025-05-19

2404 Whole-brain chemosensory responses of both C. elegans sexes

Seyedolmohadesin, M.; Fu, X.; Torkashvand, M.; Rasouli, S.; Lang, S.; Li, L.; Kalinski, C.; Cook, S. J.; Schroeder, F. C.; Yemini, E.; Venkatachalam, V.

10.1101/2025.05.15.654129 — neuroscience — Posted on 2025-05-19

2405 Mitochondrial Dynamics Through the Lens of Nonlinear Chemical Oscillations: A Theoretical Exploration Inspired by the Belousov-Zhabotinsky Reaction

Subbalakshmi, A. R.; Mirzapoiazova, T.; Kulkarni, P.; Salgia, R.

10.1101/2025.05.15.654228 — systems biology — Posted on 2025-05-19

2406 Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

Frank, S.; Persse, T.; Coleman, I. M.; Bankhead, A.; Li, D.; DeSarkar, N.; Wilson, D.; Rudoy, D.; Vashisth, M.; Galipeau, P.; Yang, M.; Hanratty, B.; Dumpit, R.; Morrissey, c.; Corey, E.; Montgomery, R.; Haffner, M.; Pritchard, C.; Vasioukhin, V.; Ha, G.; Nelson, P. S.

10.1101/2024.07.16.603734 — cancer biology — Posted on 2025-05-19

2407 Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging

Wang, S.; Dong, D.; Li, X.; Wang, Z.

10.1101/2023.05.26.542373 — bioinformatics — Posted on 2025-05-19

2408 In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis

Haney, M. S.; Shankar, A.; Olender, L.; Hsu, I.; Miyauchi, M.; Palovics, R.; Meaker, G. A.; Kaito, S.; Rizq, O.; Khoo, H. M.; Bozhilov, Y.; Igarashi, K. J.; Bhadury, J.; Munson, C.; Mack, P. K.; Tan, T.-K.; Rehwinkel, J.; Iwama, A.; Wyss-Coray, T.; Nakauchi, H.; Wilkinson, A. C.

10.1101/2022.07.22.501030 — genetics — Posted on 2025-05-19

2409 Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery

Murad, J. P.; Christian, L.; Rosa, R.; Ren, Y.; Lee, E.; Lopez, L.; Park, A.; Yang, J.; Trac, C.; Adkins, L.; Chang, W.-C.; Martinez, C.; June, C. H.; Forman, S.; Ishihara, J.; Lee, J. K.; Stern, L.; Priceman, S. J.

10.1101/2025.04.04.647304 — bioengineering — Posted on 2025-05-19

2410 Genome divergence between European anchovy ecotypes fuelled by structural variants originating from cross-hemispheric admixture

Meyer, L.; Barry, P.; Le Moan, A.; Arbiol, C.; Castilho, R.; Van der Lingen, C. D.; Chlaïda, M.; McKeown, N. J.; Ernande, B.; Bonhomme, F.; Gagnaire, P.-A.; Guinand, B.

10.1101/2024.09.15.613121 — evolutionary biology — Posted on 2025-05-19

2411 A piRNA modulates the levels of 20-hydroxyecdysone in the ovary of the German cockroach

Gonzalvo, J.; Farrus, N.; Escudero, J.; Berkova, P.; Moos, M.; Nouzova, M.; Noriega, F.; Pujal, D.; Bau, J.; Piulachs, M.-D.

10.1101/2024.10.10.617606 — developmental biology — Posted on 2025-05-19

2412 Exercise Related microRNAs in C. elegans Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs

Xia, Q.; Tang, J.; Casas-Martinez, J. C.; Li, P.; Quinlan, L. R.; Goljanek-Whysall, K.; McDonagh, B.

10.1101/2025.05.13.653755 — molecular biology — Posted on 2025-05-19

2413 Microbial Colonisation of Polyethylene in Offshore Marine Environments: Insights from the Southern and South Atlantic Oceans.

Carrillo Barragan, P.; Erni Cassola, G.; Burkhardt-Holm, P.

10.1101/2025.05.18.654703 — microbiology — Posted on 2025-05-19

2414 COVID-19 in Space: Possible Health Risks and Preparedness Guidelines

Vashishat, I.; Han, E.; Assogba, B. D.

10.1101/2025.04.23.650113 — microbiology — Posted on 2025-05-19

2415 Encoding of numerosity with robustness to object and scene identity in biologically inspired object recognition networks

Chapalain, T.; Thirion, B.; Eger, E.

10.1101/2024.09.05.611433 — neuroscience — Posted on 2025-05-19

2416 Explaining tip-of-the-tongue experiences in older adults: contributions of brain function, structure, and perfusion in relation to older adults cardiorespiratory fitness

Rahman, F.; Tsvetanov, K. A.; Feron, J.; Mullinger, K.; Joyce, K.; Gilani, A.; Fernandes, E. G.; Wetterlin, A.; Wheeldon, L. R.; Lucas, S. J. E.; Segaert, K.

10.1101/2023.12.08.570799 — neuroscience — Posted on 2025-05-19

2417 Personalized whole-brain models of seizure propagation

Lopez-Sola, E.; Mercadal, B.; Lleal-Custey, E.; Salvador, R.; Sanchez-Todo, R.; Bartolomei, F.; Wendling, F.; Ruffini, G.

10.1101/2025.05.15.654238 — neuroscience — Posted on 2025-05-19

2418 Confirmation Bias through Selective Readout of Information Encoded in Human Parietal Cortex

Park, H.; Arazi, A.; Talluri, B. C.; Celotto, M.; Panzeri, S.; Stocker, A. A.; Donner, T. H.

10.1101/2024.06.21.600060 — neuroscience — Posted on 2025-05-19

2419 GCN5L1 inhibits pyruvate dehydrogenase phosphorylation during cardiac ischemia- reperfusion injury

Bugga, P.; Stoner, M.; Manning, J.; Mushala, B.; Bhattarai, N.; Sharifi-Sanjani, M.; Scott, I.

10.1101/2024.06.03.597148 — physiology — Posted on 2025-05-19

2420 ngsAMOVA: A Probabilistic Framework for Analysis of Molecular Variance, dXY and Neighbor-Joining Trees with Low Depth Sequencing Data

Altinkaya, I.; Zhao, L.; Nielsen, R.; Korneliussen, T. S.

10.1101/2025.05.12.653431 — bioinformatics — Posted on 2025-05-19

2421 DNA methylation networks during pig fetal development: a joint fused ridge estimation approach

Wachala, K. M.; de Vos, J.; Madsen, O.; Derks, M. F. L.; Peeters, C. F. W.

10.1101/2025.05.15.654211 — bioinformatics — Posted on 2025-05-19

2422 Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex

Giladi, M.; Kredi, S.; Guardiani, C.; Aviram, L.; Vankova, P.; Man, P.; Giacomello, A.; Haitin, Y.

10.1101/2025.05.09.652838 — biochemistry — Posted on 2025-05-19

2423 GViNC: an innovative framework for genome graph comparison reveals hidden patterns in the genetic diversity of human populations

Kamaraj, V.; Gupta, A.; Raman, K.; Narayanan, M.; Sinha, H.

10.1101/2024.06.10.598220 — genomics — Posted on 2025-05-19

2424 A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

Balligand, T.; Carpenet, C.; Olive Palau, S.; Jaspers, T.; Suresh, P.; Liu, X.; Medhi, H.; Lee, Y. H.; Rashidian, M.; De Strooper, B.; Ploegh, H. L.; Dewilde, M.

10.1101/2024.11.20.624506 — immunology — Posted on 2025-05-19

2425 Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response

Federmann, S.; Westerhoff, M.; Reichert, A. S.; Fritz, G.

10.1101/2025.05.15.654253 — pharmacology and toxicology — Posted on 2025-05-19

2426 A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects

Hart, S. F. M.; Alcala, N.; Feder, A. F.; Harris, K.

10.1101/2025.05.15.654154 — cancer biology — Posted on 2025-05-19

2427 Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy

Marrocco, R.; Patel, J.; Medari, R.; Salu, P.; Lucero-Meza, E.; Brunel, S.; Martsinkovskiy, A.; Sun, S.; Gulay, K.; Jaljuli, M.; Mose, E.; Lowy, A.; Benedict, C. A.; Hurtado de Mendoza, T.

10.1101/2025.05.15.654308 — cancer biology — Posted on 2025-05-19

2428 Structure-based mechanistic principles underlying the paradoxical effects of pathological RET mutations

Fassler Bakhman, A.; Cohen, M.; Kolodny, R.; Kosloff, M.

10.1101/2024.12.26.630356 — bioinformatics — Posted on 2025-05-19

2429 Sexual antagonism, mating systems, and recombination suppression on sex chromosomes

Flintham, E.; Mullon, C.

10.1101/2025.05.15.654257 — evolutionary biology — Posted on 2025-05-19

2430 Chromatin interaction-based annotation of distal cis-regulatory elements reveals highly dynamic promoter-enhancer interactions in lymphocyte development

Tingvall-Gustafsson, J.; Jensen, C. T.; Ungerback, J.; Sigvardsson, M.

10.1101/2025.05.15.653418 — bioinformatics — Posted on 2025-05-19

2431 Congenital heart disease missense mutations in the TBX5 DNA-binding domain alter thermal stability and DNA-binding affinity

Rivera-Madera, A.; Pena-Martinez, E. G.; Messon-Bird, J. L.; Pomales-Matos, D. A.; Echevarria-Bonilla, O. L.; Sanabria-Alberto, L.; Peterson-Peguero, E. A.; Rodriguez-Martinez, J. A.

10.1101/2025.05.16.654568 — biochemistry — Posted on 2025-05-19

2432 Coexisting with humans: genomic and behavioural consequences in a small and isolated bear population

Fabbri, G.; Biello, R.; Gabrielli, M.; Torres Villaca, S.; Sammarco, B.; Fuselli, S.; Santos, P.; Ancona, L.; Peretto, L.; Padovani, G.; Sollitto, M.; Iannucci, A.; Paule, L.; Balestra, D.; Gerdol, M.; Ciofi, C.; Ciucci, P.; Mahan, C. G.; Trucchi, E.; Benazzo, A.; Bertorelle, G.

10.1101/2025.05.15.654188 — genomics — Posted on 2025-05-19

2433 Global Change Factors differentially impact Floral and Leaf Economic Traits

Manavalan, M.; Thakur, D.; Schaumberger, A.; Bahn, M.; Münzbergova, Z.

10.1101/2025.05.15.654190 — ecology — Posted on 2025-05-19

2434 Classification of indeterminate and off-target cell types within human kidney organoid differentiation

Wilson, S. B.; Vanslambrouck, J. M.; Murphy, A.; Neavin, D. R.; Powell, J. E.; Howden, S. E.; Little, M. H.

10.1101/2025.05.16.654519 — cell biology — Posted on 2025-05-19

2435 The interplay of membrane tension and FtsZ filament condensation on the initiation and progression of cell division in B. subtilis

Ramirez-Diaz, D. A.; Yin, L.; Albanesi, D.; Zheng, J.; De Mendoza, D.; Garner, E.

10.1101/2025.05.18.654715 — microbiology — Posted on 2025-05-19

2436 Classical Myelo-Proliferative Neoplasms emergence and development based on real life incidence and mathematical modeling

giraudier, s.; Baranda, A. F.; Bansaye, V.; Lauret, E.; Mounier, M.; Ugo, V.; Meleard, S.; Giraudier, S.

10.1101/2025.05.14.654143 — cancer biology — Posted on 2025-05-19

2437 Microtubule-based nucleation results in a large sensitivity to cell geometry of the plant cortical array

Saltini, M.; Deinum, E. E.

10.1101/2024.03.25.586463 — biophysics — Posted on 2025-05-19

2438 Community-promoted antibiotic resistance genes show increased dissemination among pathogens

Lund, D.; Johnning, A.; Holmström, M.; Varghaei, L.; Inda-Diaz, J. S.; Bengtsson-Palme, J.; Kristiansson, E.

10.1101/2025.05.12.653433 — bioinformatics — Posted on 2025-05-19

2439 PREDICTING RISK OF INADEQUATE MICRONUTRIENT INTAKEWITH TRANSFERABLE MACHINE LEARNING MODELS

Voukelatou, V.; Tang, K.; Lauzana, I.; Jangid, M.; Martini, G.; de Pee, S.; Knight, F.; Piovani, D.

10.1101/2025.04.08.647715 — bioinformatics — Posted on 2025-05-19

2440 The mouse pangenome reveals the structural complexity of the murine protein coding landscape

Helmy, M.; Li, J. U.; Yan, X. F.; Meade, R. K.; Anderson, E.; Chen, P.; Czechanski, A. M.; Di Domenico, T.; Flint, J.; Garrison, E.; Guarracino, A.; Gontijo, M. T.; Haggerty, L.; Heard, E.; Howe, K.; Meena, N.; Martin, F. J.; Miska, E.; Rall, I.; Ramakrishna, N. B.; Sapetschnig, A.; Sinha, S.; Sun, D.; Tricomi, F. F.; Qu, R.; Wood, J. M.; Wu, T.; Zhou, D. J.; Reinholdt, L.; Adams, D. J.; Smith, C. M.; Lilue, J.; Keane, T. M.

10.1101/2025.05.13.653481 — genomics — Posted on 2025-05-19

2441 MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion

Quack, S.; Maity, S.; America, P. P. B.; Klein, M.; Herrero del Valle, A.; Singh, R.; Smitskamp, Q.; Papini, F. S.; Broedersz, C.; Roos, W.; Modis, Y.; Dulin, D.

10.1101/2024.08.27.609867 — biophysics — Posted on 2025-05-19

2442 difFUBAR: Scalable Bayesian comparison of adaptive evolution

Sadiq, H.; Truong, P.; Danielsson, M.; Kumar, V.; Nordlinder, H. N.; Martin, D. P.; Murrell, B.

10.1101/2025.05.19.654647 — bioinformatics — Posted on 2025-05-19

2443 Disentangling urbanisation, climate effects and their interaction on ornamental colourations

Sandmeyer, L.; Lopez-Idiaquez, D.; Fargevieille, A.; Giovannini, P.; Perret, S.; Del Rey, M.; Charmantier, A.; Doutrelant, C.; Gregoire, A.

10.1101/2025.02.19.639098 — ecology — Posted on 2025-05-19

2444 Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo

Mishra, N.; Li, Y. I.; Hannezo, E.; Heisenberg, C.-P.

10.1101/2025.02.03.636134 — developmental biology — Posted on 2025-05-19

2445 IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells

Pattu, V.; Krause, E.; Chang, H.-F.; Rettig, J.; Li, X.

10.1101/2025.05.09.652839 — molecular biology — Posted on 2025-05-19

2446 Botanicals impact the bifidogenic effect and metabolic outputs of in vitro fiber fermentation by gut-derived microbiota in individual-specific ways

Deemer, D. G.; Voreades, N.; Bron, P. A.; Lindemann, S. R.

10.1101/2023.04.17.537114 — microbiology — Posted on 2025-05-19

2447 A knowledge graph and topological data analysis framework to disentangle the tomato-multi pathogens complex gene regulatory network

multari, m.; carriere, m.; Amoros-Gabarron, x.; damy, a.; lobentanzer, s.; saez-rodriguez, J.; Jaubert, S.; Dugourd, A.; BOTTINI, S.

10.1101/2025.04.09.647963 — systems biology — Posted on 2025-05-19

2448 Analyzing the morphological variation of the Galapagos mistletoePhoradendron berteroanum (Santalaceae) using herbarium specimens

Puentes-Marin, J.; Denison, A.; Villalba-Aleman, J.; Mazon-Redin, J.; Pinto, M.

10.1101/2025.05.16.654492 — plant biology — Posted on 2025-05-19

2449 Exposure time to moderately high temperature affects photosynthetic response to water deficit in Eucalyptus globulus Labill.

Portes, M. T.; Santa Cruz Damineli, D.; Chaves, M. M.; Souza, G.

10.1101/2025.05.16.654555 — plant biology — Posted on 2025-05-19

2450 Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy

Nguyen, T. T. H.; Huang, Y. X.; Poliakova, S.; Citu, C.; Mann, E.; Sopariwala, D. H.; Zhao, Z.; Kumar, A.; NARKAR, V. A.

10.1101/2025.05.15.654390 — physiology — Posted on 2025-05-19

2451 Skeletal muscle proteomic responses to energy deficit with concomitant aerobic exercise in humans

Nishimura, Y.; Langan-Evans, C.; Taylor, H. L.; Lun Foo, W.; Morton, J. P.; Shepherd, S.; Strauss, J.; Burniston, J. G.; Areta, J. L.

10.1101/2025.05.15.654297 — physiology — Posted on 2025-05-19

2452 Ancient and recent riverine gene flow contributed to the adaptive radiation of sailfin silversides in Wallace's Dreampond

10.1101/2025.04.16.648611 — evolutionary biology — Posted on 2025-05-19

2453 Loss of starvation-and-light sporulation trigger in Myxomycetes Physarum roseum

Masui, M.; Yamamoto, P. K.; Kono, N.

10.1101/2025.05.10.652879 — molecular biology — Posted on 2025-05-19

2454 Too much sugar makes plants "pregnant": maternal sucrose signals fertilization in Arabidopsis seeds

Xu, W.; Iannaccone, M.; Gomez-Paez, D.-M.; Choinard, S.; Lu, J.; Le Hir, R.; Dinant, S.; Kalmbach, L.; Feil, R.; E. Lunn, J.; Meyer, C.; Magnani, E.

10.1101/2025.05.16.654273 — plant biology — Posted on 2025-05-19

2455 Enhanced cell aggregation in the Chlamydomonas reinhardtii rbo1 mutant in response to multifactorial stress combination

Pascual, L. S.; Mohanty, D.; Sinha, R.; Nguyen, T. T.; Rowland, L.; Lyu, Z.; Joshi, T.; Mooney, B. P.; Gomez-Cadenas, A.; Fritschi, F. B.; Zandalinas, S. I.; Mittler, R.

10.1101/2025.05.16.654601 — plant biology — Posted on 2025-05-19

2456 RBP47 family members are negative regulators of heat stress tolerance in Arabidopsis thaliana

Hernandez-Sanchez, I. E.; Tarbiyyah, I.; Kearly, A.; Martinez-Seidel, F.; Maruri-Lopez, I.; Chen, Y.; S. Rissland, O.; Wang, W.; Sioud, S.; Schwarzenberg, A.; Nelson Dittrich, A. C.; Nelson, A.; Chodasiewicz, M.

10.1101/2025.05.18.654719 — plant biology — Posted on 2025-05-19

2457 Sustaining the cell energy in dynamic environments requires photosynthetic electron flows with diverse bandwidths

Madireddi, S. K.; Adler, L.; Stoffel, C.; Schroeder, M.; Tolleter, D.; Burlacot, A.

10.1101/2025.05.16.654609 — plant biology — Posted on 2025-05-19

2458 Citizen science data indicates morphological complexity of galls depends on the originating plant organ

Bessho-Uehara, K.; Takara, R.; Sano, K.; Tamura, K.

10.1101/2025.05.17.654643 — plant biology — Posted on 2025-05-19

2459 Vascular anatomy changes in tomato stems grown under simulated microgravity

Hostetler, A. N.; Kennebeck, E.; Reneau, J. W.; Caldwell, D. L.; Iyer-Pascuzzi, A. S.; Sparks, E. E.

10.1101/2025.05.16.654566 — plant biology — Posted on 2025-05-19

2460 Diploid gametes in maize by mutation of A-Type cyclins: a step towards apomeiosis and synthetic apomixis.

Skinner, D. J.; Gaikwad, A. H.; Fenner, J. A.; Green, J.; Cho, M.-J.; Kelliher, T.; Sundaresan, V.

10.1101/2025.05.16.654085 — plant biology — Posted on 2025-05-19

2461 The Role of SIAMESE in G2 Checkpoint Regulation in Arabidopsis thaliana

Schwall, M. A.; Clark, F.; Dale, R.; Roeder, A. H. K.; Kato, N.; Larkin, J. C. C.

10.1101/2025.05.16.654532 — plant biology — Posted on 2025-05-19

2462 Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes

Gokhan, I.; Li, X.; Sendek, J. M.; Mora Pagan, A. J.; Akar, F. G.; Campbell, S. G.

10.1101/2025.05.15.654389 — physiology — Posted on 2025-05-19

2463 The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels

Sauer, J.; Marksteiner, J.; Hohenegger, M.; Todt, H.; Kubista, H.; Dostal, C.; Kiss, A.; Podesser, B. K.; Salzer, I.; Koenig, X.; Stary-Weinzinger, A.; Hilber, K.; Kudlacek, O.

10.1101/2025.05.15.654221 — pharmacology and toxicology — Posted on 2025-05-19

2464 Quantitative evaluation of dogs as sentinels for Rift Valley fever virus circulation in Madagascar

Ramaroson, H. S.; Garchitorena, A.; Lacoste, V.; Andriamandimby, S. F.; Schoenhals, M.; Bastard, J.; Albrechtova, K.; Chevalier, L.; Rakotomanana, D.; Rasamoel, P. d. V.; Raliniaina, M.; Andriamahefa, H. F.; Andriamananjara, M. A.; Rasoloharimanana, L. T.; Razafimahatratra, S. L.; Ratsimbasoa, C. A.; Durand, B.; Chevalier, V.

10.1101/2025.05.16.654436 — pathology — Posted on 2025-05-19

2465 DeepTRACE: Flexible Machine Learning for Analysis and Discovery in Single Molecule Tracks

Pambos, O. J.; Kapanidis, A. N.; Wright, J. A.

10.1101/2025.05.15.654348 — biophysics — Posted on 2025-05-19

2466 DPAC: Prediction and Design of Protein-DNA Interactions via Sequence-Based Contrastive Learning

Chen, L. T.; Pulugurta, R.; Vure, P.; Chatterjee, P.

10.1101/2025.05.14.654102 — bioengineering — Posted on 2025-05-19

2467 AI assisted design of ligands for Lipocalin-2

Sgrignani, J.; Buscarini, S.; Locatelli, P.; Guerra, C.; Furlan, A.; Chen, Y.; Zoppi, G.; Cavalli, A.

10.1101/2025.05.18.654718 — biochemistry — Posted on 2025-05-19

2468 Identification and Rescue of Congenital Hyperinsulinism-Associated ABCC8 Mutations that Impair KATP Channel Trafficking

ElSheikh, A.; Kuo, Y.-Y.; E. Boodhansingh, K.; Yang, Z.; A. Stanley, C.; De Leon, D. D.; Shyng, S.-L.

10.1101/2025.05.18.654760 — biochemistry — Posted on 2025-05-19

2469 The effects of Arabian jasmine on zebrafish behavior depends on strain, sex, and personality

Atiratana, T.; Goldson, A. R.; Samosorn, S.; Rajput, N.; Praphairaksit, N.; Kenney, J. W.

10.1101/2025.05.16.654482 — animal behavior and cognition — Posted on 2025-05-19

2470 DNA methylation marks associated with body composition in children from India and the Gambia - findings from the EMPHASIS study

Issarapu, P.; Arumalla, M.; Antoun, E.; di Gravio, C.; Ward, K.; Fall, C. H. D.; Prentice, A. M.; Chandak, G. R.; Silver, M. J.

10.1101/2025.05.15.654252 — genomics — Posted on 2025-05-19

2471 Sex-Specific Differential DNA Methylation in Mild Cognitive Impairment and Alzheimers Disease

Bergmann, P. E.; Madrid, A.; Papale, L. A.; Clark, L. R.; Asthana, S.; Johnson, S. C.; Keles, S.; Hogan, K.; Alisch, R. S.

10.1101/2025.05.15.654279 — genomics — Posted on 2025-05-19

2472 A rapid and inexpensive universal PCR protocol for DNA (meta)barcoding using a one-tube, 2-step PCR

Collard, O.; Tawfeeq, M.; Ducret, H.; Flot, J.-F.

10.1101/2025.05.16.654411 — genomics — Posted on 2025-05-19

2473 A review of Sisyphini Dung Beetles (Coleoptera: Scarabaeinae) endemic to Mauritius: insights from subfossil evidence and phylogenetic analysis

Losacco, F.; Lopes, F.; Rossini, M.; Porch, N.; Krell, F. T.; Motala, S.; Daniel, G.; Tarasov, S.

10.1101/2025.05.16.654365 — evolutionary biology — Posted on 2025-05-19

2474 Reappraisal of the place of cultivated plants in the carbon budget

Muller-Feuga, A.

10.1101/2025.05.17.654640 — ecology — Posted on 2025-05-19

2475 Personalized whole-brain models of seizure propagation

Lopez-Sola, E.; Mercadal, B.; Lleal-Custey, E.; Salvador, R.; Sanchez-Todo, R.; Bartolomei, F.; Wendling, F.; Ruffini, G.

10.1101/2025.05.15.654238 — neuroscience — Posted on 2025-05-19

2476 Role of channels in the O2 permeability of murine red blood cells. III. Mathematical modeling and simulations.

Occhipinti, R.; Zhao, P.; Moss, F. J.; Boron, W. F.

10.1101/2025.03.05.639964 — physiology — Posted on 2025-05-19

2477 Immune Spatial Organization Predicts Metastasis Risk in Aggressive Localized Prostate Cancer

Yang, D. D.; Abdelnaser, A.; Wala, J.; Haas, A. J.; Barney, A. A.; Saad, E.; Crowdis, J. P.; Ricker, C. A.; Park, J.; King, M. T.; Nguyen, P. L.; Choueiri, T. K.; Tewari, A. K.; Salari, K.; Taplin, M.-E.; Wu, C.-L.; Van Allen, E. M.

10.1101/2025.05.15.654324 — bioinformatics — Posted on 2025-05-19

2478 panREPET: a reference-free pipeline for detecting shared Transposable Elements from pan-genomes to retrace their dynamics in a species

Saidi, S.; Blaison, M.; Rodriguez-Ordonez, M. d. P.; Confais, J.; Quesneville, H.

10.1101/2024.06.17.598857 — genomics — Posted on 2025-05-19

2479 The Influence of Model Violation on Phylogenetic Inference: A Simulation Study

Naser-Khdour, S.; Lanfear, R.; Minh, B. Q.

10.1101/2021.09.22.461455 — evolutionary biology — Posted on 2025-05-19

2480 Genomic insights into Plasmodium vivax and Plasmodium simium host shifts in Latin America

Lefebvre, M. J. M.; Degrugillier, F.; Arnathau, C.; Gonzalez, C. J. M.; Rondon, S.; Link, A.; Chaves, A.; Benavides, J. A.; Campos, A. A. S.; dos Santos, E.; Huff, R.; Silva, C. M. D.; Vanderheoven, E.; de Thoisy, B.; Fontaine, M. C.; Prugnolle, F.; Rougeron, V.

10.1101/2024.12.19.629455 — evolutionary biology — Posted on 2025-05-19

2481 Unveiling mode of action of anthelmintics in Caenorhabditis elegans with SydLab™, an on-a-chip automated and high-content screening system.

Duguet, T. B.; Belgrano, C.; Bourgeois, M.; Vernudachi, A.; Mouchiroud, L.; Rufener, L.

10.1101/2025.05.15.654210 — developmental biology — Posted on 2025-05-19

2482 Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats

Caldwell, A.; Yang, L.; Casazza, R. L.; Worota, R. E.; McCutcheon, C.; Creisher, P. S.; Zhan, E.; Reasoner, C.; Higgins, A.; Schountz, T.; Coyne, C. B.

10.1101/2025.05.15.654282 — developmental biology — Posted on 2025-05-19

2483 RNAi reveals a unique kinesin mediating chloroplast motility in the giant cytoplasm of Bryopsis, a coenocytic green alga

Ogawa, H. A.; Ochiai, K. K.; Shirae-Kurabayashi, M.; Yamada, M.; Goshima, G.

10.1101/2025.05.19.654777 — cell biology — Posted on 2025-05-19

2484 Unveiling immune interference: How the dendritic cell response to co-infection with Aspergillus fumigatus is modulated by human cytomegalovirus and its virokine CMVIL-10

Heilig, L.; Bussemer, L.; Strobel, L.; Huenniger, K.; Kurzai, O.; Grothey, A.; Doelken, L.; Laib, K.; Panagiotou, G.; Westermann, A.; Einsele, H.; Wurster, S.; Schaeuble, S.; Loeffler, J.

10.1101/2025.05.15.654194 — immunology — Posted on 2025-05-19

2485 Proprioceptive limit detectors mediate sensorimotor control of the Drosophila leg

Pratt, B. G.; Dallmann, C. J.; Chou, G. M.; Siwanowicz, I.; Walling-Bell, S.; Cook, A.; Sustar, A.; Azevedo, A.; Tuthill, J. C.

10.1101/2025.05.15.654260 — neuroscience — Posted on 2025-05-19

2486 From Pan-Life Phase Insights to PhaseHub: Analyzing Condensate Complexity

Liang, Q.; Gao, W.; MIAO, Y.

10.1101/2025.05.15.653974 — systems biology — Posted on 2025-05-19

2487 Differential Proteomic Analysis of DEN-Induced Hepatocellular Carcinoma in Male and Female Balb/c Mice Reveals Novel Gender Specific Markers

Salihah, S.; Tahir, M.; Bibi, B.; Sultan, R.; Larsen, M. R.; Mirza, M. R.; Mahmood, S.; Alam, M. R.; Gul, A.

10.1101/2025.05.15.654000 — cancer biology — Posted on 2025-05-19

2488 Applying telecentric stereo 3D-measurement to small Lepidopterans - bridging the macro and the microscale with isotropic micrometer resolution

Stark, A. W.; Osadare, A.; Guo, M.; Gentsch, G. J.; Boettger, D.; Brehm, G. W.; Franke, C.

10.1101/2025.05.15.654204 — biophysics — Posted on 2025-05-19

2489 SWANS: A highly configurable analysis pipeline for single-cell and single-nuclei RNA-sequencing data

Beigel, K.; Wafula, E.; Mitchelle, D. V.; Pastor, S. J.; Gong, M.; Heuckeroth, R.; Ricarte-Filho, J. C.; Franco, A. T.; Reichenberger, E. R.

10.1101/2025.05.14.654073 — bioinformatics — Posted on 2025-05-19

2490 CPP2Vec: a Representation Learning Approach for Cell-Penetrating Peptides Prediction

Svolou, S.; Konstantakos, V.; Krithara, A.; Paliouras, G.

10.1101/2025.05.15.654208 — bioinformatics — Posted on 2025-05-19

2491 Transcription factors overcome the repressive impact of Polycomb-associated methylation in tumors

Kwon, M.-K.; Park, G.; Go, D.; Park, D.; Hannenhalli, S.; Choi, S. S.

10.1101/2025.05.15.654174 — bioinformatics — Posted on 2025-05-19

2492 ASPPs multimerize protein phosphatase 1

Wei, D. T.; Morrison, K. N.; Beacham, G. M.; Beyrent, E.; Zhang, Y.; Florens, L.; Hollopeter, G.

10.1101/2025.05.16.654433 — cell biology — Posted on 2025-05-19

2493 The 18S rRNA methyltransferase, BUD23, is required for appropriate lipid and mitochondrial metabolism

Martinez-Sanchez, N.; Brümmer, A.; Barron, N. J.; Rosoff, D. B.; Liechti, A.; Voronkov, M.; Hayter, E. A.; Chamois, S.; Dreos, R.; Guex, N.; Johnson, E.; Baxter, M.; Smith, K.; Northeast, R. C.; Galli, G.; Hodson, L.; Gatfield, D.; Ray, D.; Bechtold, D.

10.1101/2025.05.16.654455 — cell biology — Posted on 2025-05-19

2494 Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage

Guest, S. L.; Velle, K. B.; Jacques, S. M.; Park, Y.; Man, J.; Titus, M. A.; Fritz-Laylin, L.

10.1101/2025.05.16.654244 — cell biology — Posted on 2025-05-19

2495 Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens

Kulicke, C. A.; Lemon, C.; Krawic, J. R.; Ramirez, L. M. N.; Kim, S.-J.; Narayanan, G. A.; Tafesse, F. G.; Hildebrand, W. H.; Dobos, K. M.; Lewinsohn, D. M.

10.1101/2025.05.14.654109 — immunology — Posted on 2025-05-19

2496 Dietary glutamine supplementation alleviates age-related cardiac dysfunction by reducing elevated H3K27me3

Le, C.; Coleman, P.; Burgoyne, T.; Su, J.; Warren, H. R.; Kumar, R.; Oexner, R. R.; Ahn, H.; Ntorla, A.; Santos, C. X. C.; Shah, A. M.; Giacca, M.; Ehler, E.; Burgoyne, J. R.

10.1101/2025.05.16.654624 — cell biology — Posted on 2025-05-19

2497 Parkin-dependent ubiquitination of TAX1BP1 directs efficient autophagic removal of defective mitochondria

Lechado-Terradas, A.; Lemke, B.; Zittlau, K.; Kahle, P. J.; Macek, B.

10.1101/2025.05.16.654474 — cell biology — Posted on 2025-05-19

2498 ER-Localized Ceramide Accumulation Due to Disrupted CERT Transport Contributes to Replicative Senescence

Chitkara, S.; Gozali, N.; Kuzmin, A.; Pliss, A.; Prasad, P.; Sancak, Y.; Atilla-Gokcumen, G. E.

10.1101/2025.05.16.654528 — cell biology — Posted on 2025-05-19

2499 The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction

Ritacco, D. A.; Shahnawaz, H.; Oduguwa, A.; Hawk, J. S.; Vizcaino, B.; Farber, D. L.; Gaudet, R. G.

10.1101/2025.05.16.654477 — cell biology — Posted on 2025-05-19

2500 A novel C. elegans respirometry assay using low-cost optical oxygen sensors

Dennis, N.; Gourlay, C.; Ezcurra, M.

10.1101/2025.05.16.654527 — cell biology — Posted on 2025-05-19

2501 Single Cell RNA Sequencing Reveals Gene Expression Continuums Along the Spatial Hierarchy of the Pulmonary Circulation

Sveiven, S.; Knutsen, C.; Zanini, F.; Cornfield, D.; Alvira, C.

10.1101/2025.05.17.654540 — cell biology — Posted on 2025-05-19

2502 Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans

Zhai, Y.; Wang, T.; Han, J.; Wu, M.; Gong, M.; Li, W.; Zhang, Z.

10.1101/2025.05.16.654472 — cell biology — Posted on 2025-05-19

2503 Insights into Cannabinoid Receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning

Oyagawa, C. R.; Woodhouse, B.; Wood, K. C.; Glass, M.; Grimsey, N. L.

10.1101/2025.02.23.639698 — pharmacology and toxicology — Posted on 2025-05-18

2504 PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility

Xiang, K.; Bartel, D. P.

10.1101/2024.10.29.620940 — bioinformatics — Posted on 2025-05-18

2505 Role of channels in the O2 permeabilityof murine red blood cells. I. Stopped-flow and hematological studies

Zhao, P.; Moss, F. J.; Occhipinti, R.; Geyer, R. R.; Huffmann, D. E.; Meyerson, H. J.; Boron, W. F.

10.1101/2025.03.05.639948 — physiology — Posted on 2025-05-18

2506 Towards foundation models that learn across biological scales

Kalfon, J.; Cantini, L.; Peyre, G.

10.1101/2025.05.16.653447 — bioinformatics — Posted on 2025-05-18

2507 Restoring data balance via generative models of T cell receptors for antigen-binding prediction

Loffredo, E.; Pastore, M.; Cocco, S.; Monasson, R.

10.1101/2024.07.10.602897 — bioinformatics — Posted on 2025-05-18

2508 FSCN1-Mediated Hepatic Gluconeogenesis Is Indispensable for Neonatal Mice Survival

Liu, X.; HU, Y.; Wu, L.; Zhang, Y.; Sang, L.; Gao, Y.; He, L.; Yang, S.; Xiong, W.; Sun, j.

10.1101/2025.05.18.654691 — molecular biology — Posted on 2025-05-18

2509 Telomerase reverse transcriptase is required for resistance to mycobacterial infection

Han, D. J.; Costa, D. M.; Luo, G.; Wright, K.; Pandey, M.; Wee, D.; Chen, Y.; Akincilar, S. C.; Tergaonkar, V.; Dorajoo, R.; Carissimo, G.; Singhal, A.; Elks, P. M.; Ellis, P. S.; Henriques, C. M.; Yan, B.; Mostowy, S.; Oehlers, S. H.

10.1101/2025.05.15.654386 — immunology — Posted on 2025-05-18

2510 A functional perspective on the conditional covariance comparison problem in dementia analysis

Guan, C.; Gangopadhyay, A.

10.1101/2023.12.19.572366 — neuroscience — Posted on 2025-05-18

2511 Characterizing the frequency-specific and spatiotemporal dynamics of β-γ Phase-Amplitude Coupling in Parkinson's disease

Loehrer, P. A.; Yassine, S.; Weber, I.; Sanner, V.; He, S. A.; Pogosyan, A.; Chen, L.; Witt, L.; Fink, G. R.; Pedrosa, D. J.; Timmermann, L.; Tan, H.

10.1101/2025.05.14.653744 — neuroscience — Posted on 2025-05-18

2512 Narrative 'twist' shifts within-individual neural representations of dissociable story features

Sava-Segal, C.; Grall, C.; Finn, E. S.

10.1101/2025.01.13.632631 — neuroscience — Posted on 2025-05-18

2513 Role of channels in the O2 permeability of murine red blood cells II. Morphological and proteomic studies

Moss, F. J.; Zhao, P.; Salameh, A. I.; Taki, S.; Wass, A. B.; Jacobberger, J. W.; Huffman, D. E.; Meyerson, H. J.; Occhipinti, R.; Boron, W. F.

10.1101/2025.03.05.639962 — physiology — Posted on 2025-05-18

2514 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Rippa, A.; Posgai, A. L.; Currlin, S.; Brusko, M.; Williams, M. D.; Kaddis, J. S.; Kusmartseva, I.; Wasserfall, C. H.; Campbell-Thompson, M.; Atkinson, M. A.

10.1101/2025.05.14.654045 — pathology — Posted on 2025-05-18

2515 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA

Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.

10.1101/2024.11.25.625221 — paleontology — Posted on 2025-05-18

2516 Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species

Ruoff, C.; Mitchell, A.; Mondal, P.; Gopalan, V.; Singh, A.; Gottesman, M.; Hannenhalli, S.

10.1101/2024.07.05.602281 — cancer biology — Posted on 2025-05-18

2517 Neural function of Netrin-1 in precancerous lesions of the pancreas

Haidar, H.; Bellon, A.; Sleiman, K.; Hocine, M.; Rama, N.; Gadot, N.; Carpizo, D. R.; Mehlen, P.; Mann, F.

10.1101/2025.05.14.654046 — cancer biology — Posted on 2025-05-18

2518 Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer

Zennami, K.; Graham, M. K.; Chikara, S.; Sysa-Shah, P.; Rafiqi, F. H.; Wang, R.; Abel, B.; Zeng, Q.; Krueger, T. E. G.; Brennen, W. N.; Ganguly, S.; Zarif, J. C.; Simons, B.; DeWeese, T. L.; De Marzo, A.; Yegnasubramanian, S.; Lupold, S. E.

10.1101/2025.05.14.654101 — cancer biology — Posted on 2025-05-18

2519 Amira: gene-space de Bruijn graphs to improve the detection of AMR genes from bacterial long reads

Anderson, D.; Lima, L.; Le, T.; Judd, L. M.; Wick, R. R.; Iqbal, Z.

10.1101/2025.05.16.654303 — bioinformatics — Posted on 2025-05-18

2520 InstaNovo-P: A de novo peptide sequencing model for phosphoproteomics

Lauridsen, J.; Ramasamy, P.; Catzel, R.; Canbay, V.; Mabona, A.; Eloff, K.; Fullwood, P.; Ferguson, J.; Kirketerp-Moller, A.; Goldschmidt, I. S.; Claeys, T.; van Puyenbroeck, S.; Lopez Carranza, N.; Schoof, E. M.; Martens, L.; Van Goey, J.; Francavilla, C.; Jenkins, T. P.; Kalogeropoulos, K.

10.1101/2025.05.14.654049 — bioinformatics — Posted on 2025-05-18

2521 Snekmer Learn/Apply: A kmer-based vector similarity approach to proteinclassification suitable for metagenomic datasets

Nitka, T. A.; Jacobson, J.; Chang, C. H.; Krause, G. R.; Wheeler, T. J.; Egbert, R. G.; Nelson, W. C.; McDermott, J. E.

10.1101/2025.05.16.654600 — bioinformatics — Posted on 2025-05-18

2522 Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice

Hedaya, O. M.; Jiang, F.; Baliga, U.; Ivanov, A.; Chen, S.; Schwartz, J.; Kawakami, Y.; Yan, C.; Yao, P.

10.1101/2025.05.18.654700 — biochemistry — Posted on 2025-05-18

2523 An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference

Alemu, R.; Terskaya, A.; Howell, M.; Guan, J.; Sands, H.; Kleinman, A.; 23andMe Research Team, ; Bann, D.; Morris, T.; Ploubidis, G. B.; Fitzsimons, E.; Mullan Harris, K.; Caspi, A.; Corcoran, D. L.; Moffitt, T. E.; Poulton, R.; Sugden, K.; Williams, B. S.; Steptoe, A.; Ajnakina, O.; Vainik, U.; Esko, T.; Estonian Biobank Research Team, ; Campbell, A.; Hayward, C.; Iacono, W. G.; McGue, M.; Krueger, R. F.; Docherty, A. R.; Shabalin, A. A.; Hertwig, R.; Koellinger, P.; Richter, D.; Goebel, J.; Ahlskog, R.; Oskarsson, S.; Magnusson, P. K. E.; Harden, K. P.; Tucker-Drob, E. M.; Pahnke, C. K. L.

10.1101/2025.05.14.653986 — genomics — Posted on 2025-05-18

2524 Exploring the interplay of complex carbohydrate intake, the microbiome CAZymes pool and short-chain fatty acid production in the human gut: insights from different cohorts in the Argentine population

Trotta, M.; Agustini, C.; Rohr, C.; Ame, R. M.; Giordano, L.; Balderramo, D.; Romagnoli, P.; vazquez, m.

10.1101/2025.05.15.654276 — genomics — Posted on 2025-05-18

2525 Genetic effects on migration behaviour contribute to increasing spatial differentiation at trait-associated loci in Estonia

Kuznetsov, I. A.; Estonian Biobank Research Team, ; Metspalu, M.; Vainik, U.; Pagani, L.; Montinaro, F.; Pankratov, V.

10.1101/2023.10.25.564036 — genetics — Posted on 2025-05-18

2526 A Framework for Transparent and Repeatable Species Range Maps

Tarr, N. M.

10.1101/2025.05.14.653500 — ecology — Posted on 2025-05-18

2527 Embryonic Stem Cell-Specific Responses to DNA Replication Stress

James, R. C.; Wang, J. K.; Bhatt, S. R.; Shadid, S. E.; Phuong, D. J.; Schimenti, J. C.

10.1101/2025.05.16.654332 — cell biology — Posted on 2025-05-18

2528 SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

Mack, R.; Flores, N. M.; Fox, G. C.; Dong, H.; Cebeci, M.; Hausmann, S.; Chasan, T.; Dowen, J.; Strahl, B. D.; Mazur, P. K.; Gozani, O.

10.1101/2025.05.16.654513 — molecular biology — Posted on 2025-05-18

2529 Incidence and attributes of chimeric COI and 18S sequences derived from nematode-infected arthropods

D'Ercole, J.; Floyd, R.; Prosser, S. W. J.; Jafarpour, S.; Hebert, P. D. N.

10.1101/2025.05.16.654383 — molecular biology — Posted on 2025-05-18

2530 TERRA transcripts and promoters from telomeric and interstitial sites

Santagostino, M.; Sola, L.; Cappelletti, E.; Gennari, N.; Piras, F. M.; Biundo, M.; Nergadze, S. G.; Giulotto, E.

10.1101/2025.05.15.654290 — molecular biology — Posted on 2025-05-18

2531 L-Arginine Hydrochloride Enables Cold-Chain-Free DNA Polymerase Storage

Shenekji, J. G.; Al-Daoud, A.; Ghrewati, A.

10.1101/2025.05.16.654417 — molecular biology — Posted on 2025-05-18

2532 Real-time Visualization of Trigger Factor on Translating Ribosomes

Nunez, E.; Saha, P.; G.Ibarluzea, M.; Muguruza-Montero, A.; M.Alicante, S.; Ramis, R.; Leonardo, A.; Bergara, A.; Villarroel, A.; Rico, F.

10.1101/2025.05.16.654432 — molecular biology — Posted on 2025-05-18

2533 Unique TMJ-specific transcriptomic signature and its medial layer: Implications in osteoarthritis

Raut, R. D.; Choudhury, C.; Chakraborty, A. K.; Singh, H.; Mehra, P.; Gerstenfeld, L.; Almarza, A.; Bais, M. V.

10.1101/2025.05.18.654737 — molecular biology — Posted on 2025-05-18

2534 Microbial Colonisation of Polyethylene in Offshore Marine Environments: Insights from the Southern and South Atlantic Oceans.

Carrillo Barragan, P.; Erni Cassola, G.; Burkhardt-Holm, P.

10.1101/2025.05.18.654703 — microbiology — Posted on 2025-05-18

2535 Uncovering the Diversity of Pathogenic Free-Living Amoebae in Freshwater Environments of Ghana: A Combined Culture Enrichment and Metabarcoding Approach

Tekle, Y. I.; Acheampong, K. O.; Adu, R. K.; Dakwab, K. B.

10.1101/2025.05.17.654667 — microbiology — Posted on 2025-05-18

2536 Elucidating the Mechanism by Which HIV-1 Nucleocapsid Mutations Confer Resistance to Integrase Strand Transfer Inhibitors

Hikichi, Y.; Burdick, R. C.; Patro, S. C.; Ding, S.-Y.; Luke, B. T.; Clark, E.; Ablan, S. D.; Wu, X.; Pathak, V. K.; Freed, E. O.

10.1101/2025.05.17.654662 — microbiology — Posted on 2025-05-18

2537 Gut microbial conversion of dietary elderberry extract to hydrocinnamic acid improves obesity-associated metabolic disorders

Alqudah, S.; DeLucia, B.; Osborn, L. J.; Markley, R. L.; Bobba, V.; Preston, S. M.; Thambidurai, T.; Nia, L. H.; Fulmer, C. G.; Sangwan, N.; Nemet, I.; Claesen, J.

10.1101/2025.05.18.654739 — microbiology — Posted on 2025-05-18

2538 Discovery and Biosynthetic Origin of 4,4'-Dihydroxy-3,3',5,5' Tetrachlorobenzophenone Produced by the Clinical Isolate Burkholderia oklahomensis

Dashti, Y.; Clarkson, G.; Mahenthiralingam, E.; Challis, G.

10.1101/2025.05.18.654707 — microbiology — Posted on 2025-05-18

2539 Sea-ice microbial community succession and the potential role of parasitoids in the maintenance of diversity

Dilliplaine, K.; Whitmore, L.; Aguilar-Islas, A.; Bolt, C.; Dumack, K.; Jin, M.; Kaufman, M.; Oggier, M.; Hennon, G.

10.1101/2025.05.18.654361 — microbiology — Posted on 2025-05-18

2540 High-resolution laminar recordings reveal structure-function relationships in monkey V1

Carr, N.; Zhu, S.; Lee, E. K.; Xia, R.; Chen, X.; Perliss, A.; Moore, T.; Chandrasekaran, C.

10.1101/2025.05.14.653875 — neuroscience — Posted on 2025-05-18

2541 Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

Musgrove, M. R. B.; Leighton, L. J.; Liau, W.-S.; Walsh, A. D.; Marshall, P. R.; Heyworth, S. M.; Bademosi, A. T. D.; Hertrich, N.; Zhao, Q.; Madugalle, S. U.; Periyakaruppiah, A.; Li, X.; Davies, J. W. A.; Ren, H.; Gong, H.; Meunier, F.; Mikhaylova, M.; Bredy, T.

10.1101/2025.05.16.654162 — neuroscience — Posted on 2025-05-18

2542 The relationship between task-related aperiodic EEG activity, neural inefficiency and verbal working memory in younger and older adults

Sghirripa, S.; Graziano, A.; Goldsworthy, M. R.

10.1101/2025.05.14.653957 — neuroscience — Posted on 2025-05-18

2543 A Priming Circuit Controls the Olfactory Response and Memory in Drosophila

Yang, H.; Jiang, Y.; Kunes, S.

10.1101/2025.03.06.641741 — neuroscience — Posted on 2025-05-18

2544 Engineered Acinetobacter baylyi ADP1-ISx cells are sensitive DNA biosensors for antibiotic resistance genes and a fungal pathogen of bats

Chuong, J.; Brown, K. W.; Mishler, D. M.; Gifford, I.; Barrick, J. E.

10.1101/2025.05.17.654686 — synthetic biology — Posted on 2025-05-18

2545 Probing protein-protein interactions with drag flow: A case study of F-actin and tropomyosin

Bages, C.; Chabanon, M.; Kools, W.; Dos Santos, T.; Pages, R.; Sirkia, M. E.; Leduc, C.; Houdusse, A.; Jegou, A.; Romet-Lemonne, G.; Wioland, H.

10.1101/2025.05.14.653996 — biophysics — Posted on 2025-05-18

2546 eSPred: Explainable scRNA-seq Prediction via Customized Foundation Models and Pathway-Aware Fine-tuning

Sun, L.; Yang, Q.; Zhang, J.; Guo, W.; Lin, L.

10.1101/2025.05.14.654052 — bioinformatics — Posted on 2025-05-18

2547 Magnetically Responsive Nanocultures for Direct Microbial Assessment in Soil Environments

Usman, H.; Molaei, M.; House, S.; Haase, M. F.; Dennis, C. L.; Niepa, T. H. R.

10.1101/2025.05.17.654660 — bioengineering — Posted on 2025-05-18

2548 Guiding humans towards ergonomic postures using an active exoskeleton

Gomes, W.; Quesada, L.; Berret, B.; Vignais, N.; Verdel, D.

10.1101/2025.05.14.653966 — bioengineering — Posted on 2025-05-18

2549 An Anisotropic Reactive Viscoelastic Model of the Rhesus Macaque Cervix for Studying Cervical Remodeling

Cordon, C. A. D.; Fang, S.; Rosado-Mendez, I. M.; Ateshian, G.; Hall, T. J.; Feltovich, H.; Myers, K. M.

10.1101/2025.05.14.654071 — bioengineering — Posted on 2025-05-18

2550 Molecular basis behind the isoprene emission diversity in Fagaceae

Koita, S.; Munakata, R.; Fukushima, K.; Nagano, A. J.; Ikezaki, Y.; Satake, A.; Saito, T.; Miura, K.; Sugiyama, A.; Yazaki, K.

10.1101/2025.05.17.654689 — biochemistry — Posted on 2025-05-18

2551 Mutation-selection-drift balance models of complex diseases

Berg, J. J.; Li, X.; Riall, K.; Hayward, L.; Sella, G.

10.1101/2025.05.18.654722 — genetics — Posted on 2025-05-18

2552 Multi ligand sensing by a bacterial histidine kinase through inhibition of dimerization

Sankhe, G. D.; Xing, J.; Xiao, M.; Buglino, J. A.; Li, H.; Jouline, I.; Glickman, M.

10.1101/2025.05.18.654591 — microbiology — Posted on 2025-05-18

2553 The polyamine naphthyl-acetyl spermine trihydrochloride (NASPM) lacks specificity for Ca2+-permeable AMPA receptors and suppresses seizure like activity in human brain tissue by inhibition of NMDA receptors.

Podesta, A.; Monni, L.; Arnold, F. L.; Arnold, J.; Bertelli, S.; xu, R.; Onken, J.; Thomale, U.-W.; Kalbhenn, T.; Simon, M.; Sauvigny, T.; Alle, H.; Plested, A. J.; Holtkamp, M.; Geiger, J. R.; Fidzinski, P.

10.1101/2025.05.14.653650 — neuroscience — Posted on 2025-05-18

2554 Longitudinal single-cell analysis reveals RUNX1T1 as an early driver in treatment-induced neuroendocrine transdifferentiation

Ni, Y.; Lin, D.; Shi, M.; Lin, Y.-Y.; Xue, H.; Dong, X.; Liu, L.; Sar, F.; Wu, R.; Morova, T.; Haegert, A.; Bell, R.; Pang, X.; Classen, A.; Wang, Y.; Chen, J.; Volik, S.; Bihan, S. L.; Lack, N.; Ong, C.; Wang, G.; Zeng, H.; Collins, C.; Wang, Y.

10.1101/2025.05.14.653660 — cancer biology — Posted on 2025-05-18

2555 Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression

Jolly, J. T.; Al-Hamaly, M. A.; Smith, C. N.; Spielmann, H. P.; Blackburn, J. S.

10.1101/2025.05.14.654016 — cancer biology — Posted on 2025-05-18

2556 A Spectral Image Scanning Microscope for Multi-Color High-Resolution Imaging

Bram, L.; Tal-Friedman, O.; Fibeesh, N.; Bar-Sinai, Y.; Flaxer, E.; Roichman, Y.; Ebenstein, Y.; Jeffet, J.

10.1101/2025.05.14.653993 — biophysics — Posted on 2025-05-18

2557 DNA methylation networks during pig fetal development: a joint fused ridge estimation approach

Wachala, K. M.; de Vos, J.; Madsen, O.; Derks, M. F. L.; Peeters, C. F. W.

10.1101/2025.05.15.654211 — bioinformatics — Posted on 2025-05-18

2558 Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

Mahajan, A.; Ratti, F.; Wang, B.; El-Samad, H.; Kaufman, J. H.; Gopalakrishnan, V.

10.1101/2025.05.14.654062 — bioinformatics — Posted on 2025-05-18

2559 An in vivo rat lumbar spine instability model induced by intervertebral disc injury

Xiao, F.; Noort, W.; Levenez, J.; Han, J.; van Dieën, J. H.; Maas, H.

10.1101/2025.05.14.653956 — bioengineering — Posted on 2025-05-18

2560 Ambient Light Impacts Innate Behaviors of New-World and Old-World Mice

Reinhard, K.; Vastenavondt, R.; Crevits, B.; De Boever, S.; Liao, P.-Y.; Tortella, L.; Farrow, K.

10.1101/2025.05.14.653927 — neuroscience — Posted on 2025-05-18

2561 Estradiol alters actin and protrusion dynamics in endometriotic epithelial cells

Banerjee, S.; Herr, C.; Losert, W.; Stroka, K.

10.1101/2025.05.14.654086 — biophysics — Posted on 2025-05-18

2562 Modeling Immunosenescence on-a-chip: a platform for cancer vaccine efficacy assessment

Maity, S.; Hassani Najafabadi, A.; Kawakita, S.; Khorsandi, D.; Yilgor, C.; Jewell, C.; Mohaghegh, N.; Dokmeci, M. R.; Khademhosseini, A.; Jucaud, V.

10.1101/2025.05.14.654059 — bioengineering — Posted on 2025-05-18

2563 Inorganic profiles of preimplantation embryos reveal a role for zinc in blastocyst development

Balough, J. L.; O'Halloran, T. V.; Duncan, F. E.; Woodruff, T. K.

10.1101/2025.05.14.654061 — developmental biology — Posted on 2025-05-18

2564 The decameric repeat (DR) of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity

Han, Y.; Sealey, L.; Fu, Y.; Delfing, B. M.; Lockhart, C.; Chilin, L.; Tiwari, S.; Jafri, M. S.; Klimov, D.; Wu, Y.

10.1101/2025.05.14.654117 — immunology — Posted on 2025-05-18

2565 In-vivo evidence for increased tau deposition in temporal lobe epilepsy

Cruces, R. R.; Lam, J.; Arafat, T.; Royer, J.; Chen, J.; Sahlas, E.; Dascal, A.; Pana, R.; Hopewell, R.; Hsiao, C. H.-H.; Massarweh, G.; Soucy, J.-P.; Villeneuve, S.; Caciagli, L.; Koepp, M. J.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B.

10.1101/2025.05.14.654095 — neuroscience — Posted on 2025-05-18

2566 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA

Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.

10.1101/2024.11.25.625221 — paleontology — Posted on 2025-05-18

2567 Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity

Karagiannis, T. T.; Chen, Y.; Bald, S.; Tai, A.; Milman, S.; Andersen, S. L.; Perls, T. T.; Segre, D.; Sebastiani, P.; Short, M. I.

10.1101/2025.05.14.654104 — bioinformatics — Posted on 2025-05-18

2568 fMRIPrep Lifespan: Extending A Robust Pipeline for Functional MRI Preprocessing to Developmental Neuroimaging

Goncalves, M.; Moser, J.; Madison, T. J.; McCollum, r.; Lundquist, J. T.; Fayzullobekova, B.; Hadera, L.; Pham, H. H. N.; Moore, L. A.; Houghton, A. M.; Conan, G.; Styner, M. A.; Alexopoulos, D.; Smyser, C. D.; Stoyell, S. M.; Koirala, S.; Nelson, S. M.; Weldon, K. B.; Lee, E.; Hermosillo, R. J. M.; Vizioli, L.; Yacoub, E.; Patel, G. H.; Sanchez, J.; Wengler, K.; Salo, T.; Satterthwaite, T. D.; Elison, J. T.; Markiewicz, C. J.; Poldrack, R. A.; Feczko, E.; Esteban, O.; Fair, D. A.

10.1101/2025.05.14.654069 — bioinformatics — Posted on 2025-05-18

2569 Aggregating multimodal cancer data across unaligned embedding spaces maintains tumor of origin signal

Kirchgaessner, R.; Keutler, K.; Sivakumar, L.; Song, X.; Ellrott, K.

10.1101/2025.05.14.653900 — bioinformatics — Posted on 2025-05-18

2570 Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery

Hall, L. A.; Guenter, R.; Queiroz, R. G.; Jackson, A.; Golivi, Y.; Watts, J.; Zhang, Y.; Rathbun, L.; Rose, J. B.; Larimer, B. M.

10.1101/2025.05.14.654066 — bioengineering — Posted on 2025-05-18

2571 Comparative Analysis of Indole Derivative Production Among Clinical Isolates of Fusobacterium nucleatum

Scano, C. J.; Choudhury, A.; Rojo, M.; Lavado, R.; Zaharas, G.; Hawkins, J.; Greathouse, L.

10.1101/2025.05.16.654558 — microbiology — Posted on 2025-05-18

2572 Multi-level orchestration of γδ T cell development and central nervous system inflammation by retinoic acid

Fares da Silva, M. G. F.; Agerholm, R.; Sumaria, N.; Rizk, J.; Fiske, J.; Catafal-Tardos, E.; Baglioni, M. V.; Secci, D.; Sebastian, P. P.; Pennington, D.; Bekiaris, V.

10.1101/2020.08.12.247510 — immunology — Posted on 2025-05-18

2573 Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

Banik, D.; Ward, C.; Zhang, Z.; Chakraborty, S.; Heraghty, D.; Suresh, P.; Li, B.; Kedia, S.; Davis, S.; Roy, J.; Chapman, M.; Mahata, B.; Klenerman, D.

10.1101/2024.08.29.610222 — immunology — Posted on 2025-05-18

2574 Potent neutralization of Marburg virus by a vaccine-elicited monoclonal antibody

Addetia, A.; Perruzza, L.; Park, Y.-J.; McCallum, M.; Stewart, C.; Brown, J. T.; Donati, A.; Culap, K.; Balmelli, A.; Gazi, M.; Carrion, R.; Corti, D.; Benigni, F.; Veesler, D.

10.1101/2025.05.14.654121 — immunology — Posted on 2025-05-18

2575 Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors

Mishra, D. K.; Morris, S. M.; Popovski, D.; Girard, E. J.; Bondoc, A.; Kumar, S. S.; Andrade, A. F.; Zhu, X.; Yao, F.; Brusniak, M.-Y.; Umaru, B.; Crotty, E. E.; Brasel, K.; Pakiam, F.; Russo, C.; Zeinieh, M.; Biery, M. C.; Coxon, M.; Conti, H.; Clarke, M.; Lu, M.; Rutka, J.; Llivichuzhca-Loja, D.; Konnikova, L.; Fouladi, M.; Jabado, N.; Huang, A.; Olson, J. M.; Drissi, R.

10.1101/2025.05.14.654106 — immunology — Posted on 2025-05-18

2576 High-Throughput Human Gut Immune Co-Culture Model for Evaluating Inflammatory Bowel Disease Anti-Inflammatory Therapies

Boazak, E.; Peddibhotla, S.; Boone, L. A.; Taylor, E.; McQueen, B. E.

10.1101/2025.05.14.654072 — immunology — Posted on 2025-05-18

2577 T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma

Sywanycz, S.; Hill, B. L.; Miller, Z. A.; Turner, G.; Huang, L.; Polen, K.; Lee, R. J.; Carey, R. M.

10.1101/2025.05.14.654120 — cancer biology — Posted on 2025-05-18

2578 Differential effects of the D1/S264V mutation in Photosystem II with either PsbA1 or PsbA3 on QB, non-heme Iron, and the associated hydrogen-bond network

Tada, K.; Yamagata, K.; Koyama, K.; Selles, J.; Boussac, A.; Sugiura, M.

10.1101/2025.05.14.654172 — biophysics — Posted on 2025-05-18

2579 Athlytics: A Computational Framework for Longitudinal Analysis of Exercise Physiology Metrics from Wearable Sensor Data

HE, Z.

10.1101/2025.05.01.651597 — bioinformatics — Posted on 2025-05-18

2580 Comparative Analysis of Indole Derivative Production Among Clinical Isolates of Fusobacterium nucleatum

Scano, C. J.; Choudhury, A.; Rojo, M.; Lavado, R.; Zaharas, G.; Hawkins, J.; Greathouse, L.

10.1101/2025.05.16.654558 — microbiology — Posted on 2025-05-18

2581 Accelerated design of Escherichia coli genomes with reduced size using a whole-cell model and machine learning

Gherman, I. M.; Sharma, K.; Rees-Garbutt, J. P.; Pang, W.; Abdallah, Z. S.; Gorochowski, T. E.; Grierson, C. S.; Marucci, L.

10.1101/2023.10.30.564402 — bioengineering — Posted on 2025-05-18

2582 Lost in the woods: shifting habitats can lead phylogeography astray

Neher, R. A.

10.1101/2024.07.03.601889 — evolutionary biology — Posted on 2025-05-18

2583 Intracellular pH modulates vimentin remodeling in response to oxidants

Martinez, A. E.; Martinez-Cenalmor, P.; Gonzalez-Jimenez, P.; Vidal-Verdu, C.; Pajares, M. A.; Perez-Sala, D.

10.1101/2023.12.21.572888 — cell biology — Posted on 2025-05-18

2584 The relationship between task-related aperiodic EEG activity, neural inefficiency and verbal working memory in younger and older adults

Sghirripa, S.; Goldsworthy, M. R.; Graziano, A.

10.1101/2025.05.14.653957 — neuroscience — Posted on 2025-05-18

2585 Dopaminergic processes predict temporal distortions in event memory

Morrow, E.; Huang, R.; Clewett, D.

10.1101/2025.05.14.654133 — neuroscience — Posted on 2025-05-18

2586 Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons

Souza, G. M. P. R.; Thakkalapally, H.; Berry, F. E.; Atongazi, U. M.; Stornetta, D. S.; Abbott, S. B. G.

10.1101/2025.05.14.654157 — neuroscience — Posted on 2025-05-18

2587 PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After Injury

Menon, A. S.; Kumaran, M.; Beji, D. S.; Kesireddy, D. K.; Sahu, Y.; Banerjee, S.; Manjunath, S.; Sanyal, K.; Konda, M.; Venkatesh, I.

10.1101/2025.05.14.654166 — neuroscience — Posted on 2025-05-18

2588 Nonphotochemical quenching changes with abiotic stressor and developmental stages

Sahay, S.; de Bernardeaux, G.; Gamba, D.; Lasky, J. R.; Glowacka, K.

10.1101/2025.05.14.654125 — physiology — Posted on 2025-05-18

2589 Early development of the glucocorticoid stress response in dyeing poison frog tadpoles

Surber, L. L.; Jimenez, L. S.; Mobo, L. W.; Westrick, S. E.; Fischer, E. K.

10.1101/2024.05.31.596457 — physiology — Posted on 2025-05-18

2590 Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin's biochemical activity without changing thick filament structure

Mohran, S.; Kooiker, K. B.; Naim, A.; Pilagov, M.; Asencio, A.; Turner, K.; ma, w.; Flint, G. V.; Jiang, S.; Zhao, J.; McMillen, T. S.; Mandrycky, C.; Mahoney-Schaefer, M.; Irving, T.; Tanner, B. C. W.; Kad, N. M.; Regnier, M.; Moussavi-Harami, F.

10.1101/2025.05.14.654110 — biophysics — Posted on 2025-05-18

2591 Minimally invasive and in situ capacitive sensing of cardiac biomarker from interstitial fluid

Mirzajani, H.; Zolfaghari, P.; Koca, B. Y.; Urey, H.

10.1101/2025.05.14.654153 — bioengineering — Posted on 2025-05-18

2592 Microphysiological engineering of the capillary interface of substantia nigra dopaminergic neurons to study vascular alterations in Parkinson's Disease

Alim, A.; Baek, Y.; Lee, M.; Paek, J.

10.1101/2025.05.14.654131 — bioengineering — Posted on 2025-05-18

2593 Is individual recognition immutable? Subordinate hermit crabs fight with a familiar but weaponless dominant

YASUDA, C.

10.1101/2025.05.14.654137 — animal behavior and cognition — Posted on 2025-05-18

2594 A nonequilibrium framework for community responses to pulse perturbations

Medeiros, L. P.; Neubert, M. G.; Sosik, H. M.; Munch, S. B.

10.1101/2025.05.14.654148 — ecology — Posted on 2025-05-18

2595 The thermal benefits of a mound-burrow system in a semi-desert Australian landscape: will this pebble fortress provide refuge from climate change?

Firman, R. C.; Rubenstein, D. R.

10.1101/2025.05.14.654155 — ecology — Posted on 2025-05-18

2596 Using computer vision to quantify facial expressions of children with autism during naturalistic social interactions

Manelis, L.; Barami, T.; Ilan, M.; Meiri, G.; Menashe, I.; Soskin, E.; Sofer, C.; Dinstein, I.

10.1101/2025.05.14.653948 — bioengineering — Posted on 2025-05-18

2597 A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity

Shimanaka, Y.; Tol, M. J.; Rocha-Roa, C.; Jellinek, M. J.; Cui, L.; Bender, A.; Bedard, A. H.; Milner, M. G.; Melillo, B.; Shoucri, B. M.; Wong, A.; Williams, K. J.; Stiles, L.; Shum, M.; Weston, T. A.; Cohn, W.; Whitelegge, J. P.; Budin, I.; Bertholet, A. M.; Cravatt, B. F.; Young, S. G.; Houten, S. M.; Argmann, C.; Ford, D. A.; Liesa, M.; Shirihai, O. S.; Vanni, S.; Tontonoz, P.

10.1101/2025.05.15.654206 — physiology — Posted on 2025-05-18

2598 Scalability of Random Forest in Myoelectric Control

Jiang, X.; Ma, C.; Nazarpour, K.

10.1101/2025.03.04.641468 — bioengineering — Posted on 2025-05-18

2599 Jchain-Diphtheria Toxin Receptor Mice Allow for Diphtheria Toxin-Mediated Depletion of Antibody-Secreting Cells and Analysis of Differentiation Kinetics

Pioli, K. T.; Ritchie, M.; Haq, H.; Pioli, P. D.

10.1101/2024.05.06.592703 — immunology — Posted on 2025-05-18

2600 Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancer

Salehi, S.; Stroobant, E. E.; Lees, H.; Lin, Y.-H.; Shimada, S.; Abate, M.; Zatzman, M. J.; Ceglia, N.; Freeman, S.; Laszkowska, M.; Maron, S. B.; McPherson, A.; Rusk, N.; Havasov, E.; Drebin, H.; Gu, P.; Tang, L. H.; Janjigian, Y. Y.; Soldatov, R.; Chaligne, R.; Shah, S. P.; Strong, V. E.; Vardhana, S. A.

10.1101/2025.05.05.651897 — immunology — Posted on 2025-05-18

2601 IFNγ regulates MR1 transcription and antigen presentation

Huber, M. E.; Larson, E. A.; Lust, T. N.; Heisler, C. M.; Harriff, M. J.

10.1101/2025.02.09.637183 — immunology — Posted on 2025-05-18

2602 Genetic changes linked to two different syndromic forms of autism enhance reinforcement learning in early adolescent male but not female mice

Chase, J.; Li, J.-J.; Lin, W. C.; Tai, L.-H.; Castro, F.; Collins, A. G. E.; Wilbrecht, L.

10.1101/2025.01.15.633099 — neuroscience — Posted on 2025-05-18

2603 Cardiac Adaptations in the Cave Nectar Bat Eonycteris spelaea: Insights into Metabolic Resilience and Stress Response

Yu, F.; Gamage, A. M.; Kp, M. M. J.; Foo, R.; Lin, Y.-H.; Wang, L.; Pua, C. J.; Chan, W.; Crespo-Avilan, G. E.; Pena, E. M.; Hong, L. Z.; Iyer, A.; Ghosh, S.; Liehn, E. A.; Kovalik, J.-P.; Wang, L.-F.; Ramachandra, C. J.; Hausenloy, D. J.

10.1101/2025.05.15.653669 — systems biology — Posted on 2025-05-18

2604 Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry

Boatman, A. K.; Chappel, J. R.; Kirkwood-Donelson, K. I.; Fleming, J. F.; Reif, D. M.; Schymanski, E. L.; Rager, J. R.; Baker, E.

10.1101/2025.01.27.634925 — scientific communication and education — Posted on 2025-05-18

2605 Intercellular compartmentation of trehalose 6-phosphate metabolism in Setaria viridis leaves

Tonetti, T.; Rojas, B. E.; Feil, R.; Seimandi, C.; Lucero, L. E.; Cabello, J. V.; Calace, P.; Saigo, M.; Arrivault, S.; Stitt, M.; Lunn, J. E.; Figueroa, C. M.

10.1101/2024.08.16.608293 — plant biology — Posted on 2025-05-18

2606 STPath: A Generative Foundation Model for Integrating Spatial Transcriptomics and Whole Slide Images

Huang, T.; Liu, T.; Babadi, M.; Ying, R.; Jin, W.

10.1101/2025.04.19.649665 — pathology — Posted on 2025-05-18

2607 Mechanistic Insights into the Selective Targeting of MLX to Triacylglycerol-Rich Lipid Droplets

Braun, R. J.; Swanson, J. M.

10.1101/2024.07.15.603605 — biophysics — Posted on 2025-05-18

2608 decemedip: hierarchical Bayesian modeling for cell type deconvolution of immunoprecipitation-based DNA methylomes

Shen, N.; Zhang, Z.; Baca, S.; Korthauer, K.

10.1101/2025.05.09.653152 — bioinformatics — Posted on 2025-05-18

2609 Cross-expression meta-analysis of 695 brain samples reveals coordinated gene expression across spatially adjacent cells

Sarwar, A.; Rue, M.; French, L.; Cross, H.; Choi, S.; Chen, X.; Gillis, J.

10.1101/2024.09.17.613579 — bioinformatics — Posted on 2025-05-18

2610 Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

Benning, F. M. C.; Bell, T. A.; Nguyen, T. H.; Syau, D.; Connell, L. B.; Liao, Y.-T.; Keating, M.; Coughlin, M.; Nordstrom, A. E. H.; Ericsson, M.; daCosta, C. J. B.; Chao, L. H.

10.1101/2024.04.26.591372 — evolutionary biology — Posted on 2025-05-18

2611 Jumbo phage-mediated transduction of genomic islands

Zhao, Y.; Ma, Y.; Vasileiou, C.; Farr, A. D.; Rogers, D. W.; Rainey, P. B.

10.1101/2024.08.29.610337 — microbiology — Posted on 2025-05-18

2612 Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner

Durand-de Cuttoli, R.; Issler, O.; Pedersen, S. M. B.; Yakubov, B.; Jahan, N.; Abid, A.; Kasparov, S.; Granizo, K.; Ahmed, S.; Russo, S. J.; Nestler, E. J.; Sweis, B. M.

10.1101/2024.05.08.592609 — neuroscience — Posted on 2025-05-18

2613 Hypoxia and Cognitive Ability in Humans: A Systematic Review and Meta-Analysis

Mckeown, D. J.; Angus, D. J.; Moustafa, A. A.; Schinazi, V. R.

10.1101/2025.05.15.654374 — neuroscience — Posted on 2025-05-18

2614 A multi-model approach defines function altering MECP2 missense variants identified in individuals with autism spectrum disorder

Chen, E.; Schmitt, J.; McIntosh, G.; Young, B.; Lian, T.; Liu, J.; Chen, K.; Liston, J. B.; MacDonald, L.; Wang, B.; Medina Giro, S.; Boehme, B.; Das, M.; Indran, S.; Chao, J.; Rogic, S.; Pavlidis, P.; Allan, D. W.; Loewen, C.

10.1101/2024.08.13.607763 — neuroscience — Posted on 2025-05-18

2615 Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from Methylated DNA Sequencing data (MeD-seq)

Hazelaar, D. M.; Boers, R. G.; Boers, J. B.; de Weerd, V.; Helmijr, J.; Jansen, M. P.; Verheul, H. M.; Verhoef, C.; Gribnau, J.; Martens, J. W.; Makrodimitris, S.; Wilting, S. M.

10.1101/2025.01.21.633371 — bioinformatics — Posted on 2025-05-17

2616 WASTER: Practical de novo phylogenomics from low-coverage short reads

Zhang, C.; Nielsen, R.

10.1101/2025.01.20.633983 — bioinformatics — Posted on 2025-05-18

2617 Estimation of substitution and indel rates via k-mer statistics

HERA, M. R.; Medvedev, P.; Koslicki, D.; Blanca, A.

10.1101/2025.05.14.653858 — bioinformatics — Posted on 2025-05-18

2618 Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

Xiang, L.; Stewart, M.; Mooney, K.; Dai, M.; Drennan, S.; Holland, S.; Quentel, A.; Sabuncu, S.; Kingston, B. R.; Dengos, I.; Bonic, K.; Goncalves, F.; Yi, X.; Ranganathan, S.; Branchaud, B. P.; Muldoon, L. L.; Barajas, R. F.; Fischer, J. M.; Yildirim, A.

10.1101/2024.02.21.580762 — bioengineering — Posted on 2025-05-18

2619 A non-genetic meiotic repair program inferred from spore survival values in fission yeast wild isolates: a clue for an epigenetic ratchet-like model of ageing?

Marsellach, X.

10.1101/223685 — genetics — Posted on 2025-05-17

2620 Synergistic and independent roles for Nodal and FGF in zebrafish CPC migration and asymmetric heart morphogenesis

Gonzalez, V.; Grant, M. G.; Suzuki, M.; Christophers, B.; Williams, J. R.; Burdine, R. D.

10.1101/2024.01.05.574380 — developmental biology — Posted on 2025-05-18

2621 Prg4+ fibro-adipogenic progenitors in muscle are crucial for bone fracture repair

He, Q.; Lu, J.; Liang, Q.; Yao, L.; Sun, T.; Wang, H.; Duffy, M.; Jiang, X.; Lin, Y.; Lee, J.-H.; Ahn, J.; Dyment, N.; Mourkioti, F.; Boerckel, J. D.; Qin, L.

10.1101/2025.05.14.654160 — cell biology — Posted on 2025-05-17

2622 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway

Tsai, Y.-T.; Frederic-Lipp, N.; Varma, R.; Seidel, O.; Laguerre, A.; Solorio-Kirpichyan, K.; Wong, A.; Brea, R. J.; McGregor, G. H.; Cordes, T.; Devaraj, N. K.; Kuerschner, L.; Neal, S. E.; Metallo, C.; Budin, I.

10.1101/2025.05.13.652513 — cell biology — Posted on 2025-05-18

2623 Interferon-β induction heterogeneity during KSHV infection is correlated to expression and activation of enhanceosome transcription factors other than IRF3

Kaku, M.; Gaglia, M. M.

10.1101/2024.12.22.629998 — microbiology — Posted on 2025-05-17

2624 Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

Arzamasov, A. A.; Rodionov, D. A.; Hibberd, M. C.; Guruge, J. L.; Kent, J. D.; Kazanov, M. D.; Leyn, S. A.; Elane, M. L.; Sejane, K.; Furst, A.; Bode, L.; Barratt, M. J.; Gordon, J.; Osterman, A.

10.1101/2024.07.06.602360 — microbiology — Posted on 2025-05-17

2625 Strand-swapping in the LolA-like protein GerS promotes the allosteric activation of a bacterial amidase in Clostridioides difficile

Bouchier, J. M.; Shen, A.

10.1101/2025.01.13.632879 — microbiology — Posted on 2025-05-18

2626 Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex

Dellal, S.; Zurita, H.; Kruglikov, I.; Valero, M.; Abad-Perez, P.; Geron, E.; Meng, J. H.; Pronneke, A.; Hanson, J. L.; Mir, E.; Ongaro, M.; Wang, X.-J.; Buzsaki, G.; Machold, R. P.; Rudy, B.

10.1101/2025.02.26.640383 — neuroscience — Posted on 2025-05-17

2627 Peripheral CGRP engages brain-wide electrical network activity of migraine

Johnson, M. S.; Eberle, M.; Hultman, I.; Zhang, X.; Filali, Y.; Hing, B.; Matkovich, M.; Jimenez, A.; Adegboyo, A.; Velamuri, R.; Miller, J.; Chan, K.-S.; Srivastava, S.; Hultman, R.

10.1101/2024.11.14.622885 — neuroscience — Posted on 2025-05-17

2628 Computing the effects of excitatory-inhibitory balance on neuronal input-output properties

Reyes, A. D.

10.1101/2025.03.09.642210 — neuroscience — Posted on 2025-05-17

2629 Inactivation of primate area V4 reveals inductive biases in visual learning.

Laamerad, P.; Krause, M. R.; Guitton, D.; Pack, C. C.

10.1101/2025.03.11.642616 — neuroscience — Posted on 2025-05-17

2630 Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains

LeBlanc, C. J.; Stefani, J.; Soriano, M.; Lam, A.; Zintel, M. A.; Kotha, S. R.; Chase, E.; Pimentel-Solorio, G.; Vunnum, A.; Flug, K. L.; Fultineer, A. T.; Hummel, N.; Staller, M. V.

10.1101/2024.12.03.626510 — systems biology — Posted on 2025-05-17

2631 Loss of PIF7 attenuates shade and elevated temperature responses throughout the lifecycle in Pennycress

Jawahir, V.; Griffiths, M.; Adam, S.; Borphukan, B.; Sanguinet, K. A.; Phippen, W.; Wesley, T.; Heller, N.; Nusinow, D. A.

10.1101/2025.03.17.643809 — plant biology — Posted on 2025-05-17

2632 Alectinib Polypharmacology Enhances Response to Spliceosome Disruption

Ma, Y.; Poon, E.; Jin, C.; Martins da Costa, B.; Xu, Y.; Quazi, S.; Zourdoumis, N.; Wickremesinghe, C.; Chesler, L.; Keun, H. C.; Nijhuis, A.

10.1101/2025.03.28.644532 — cancer biology — Posted on 2025-05-17

2633 MvfR shapes Pseudomonas aeruginosa Interactions in Polymicrobial Contexts: Implications for Targeted Quorum Sensing Inhibition

Wheeler, K.; OH, M. W.; Fusco, J.; Mershon, A.; Kim, E.; De Oliveira, A.; Rahme, L.

10.1101/2025.05.16.654325 — microbiology — Posted on 2025-05-17

2634 A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Liccione, M. F.; Scobey, T.; Froggatt, H. M.; Pajon, C.; Yount, B. L.; Yin, Q.; Spence, T. N.; Walter, E. B.; Saunders, K. O.; Edwards, R. J.; Baric, R. S.; Haynes, B. F.; Cain, D. W.; Sheahan, T. P.; Wrapp, D.

10.1101/2025.05.14.654097 — immunology — Posted on 2025-05-17

2635 Intraepithelial lymphocytes exhibit selective immunity to intestinal pathogens

Chawla, A. S.; James, O. J.; Bhattacharya, P.; Dikovskaya, D.; Hodge, S.; Robinson, L.; Vandereyken, M.; McSorley, H. J.; Pawlowic, M. C.; Swamy, M.

10.1101/2025.05.14.654011 — immunology — Posted on 2025-05-17

2636 Targeted Irradiation and STAT3 Inhibition Reprogram the AML Microenvironment and Extend Survival: Toward Translational Immunoradiotherapy

Sargur Madabushi, S.; Brooks, J.; Zuro, D.; Yu-Lin, S.; Kaniowski, D.; Ghimire, H.; Eun Lim, J.; Abdelhamid, A. M. H.; Ya-Huei, K.; Marcucci, G.; Wong, J.; Al Malki, M.; Stein, A.; Kortylewski, M.; Hui, S.

10.1101/2025.05.14.653587 — immunology — Posted on 2025-05-17

2637 Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewing intestinal inflammation

Yamashita, Y.; Kosako, H.; Kato, T.; Okamura, T.; Tane, M.; Tabata, S.; Iwabuchi, S.; Nakashima, K.; Tanaka, K.; Shiraishi, K.; Uchihara, Y.; Sasaki, I.; Okuzaki, D.; Shibata, A.; Mizushima, T.; Hemmi, H.; Kanazawa, N.; Kodama, S.; Ohshima, K.; Hashimoto, S.; Fujitani, Y.; Sonoki, T.; Tamura, S.; Kaisho, T.

10.1101/2025.05.14.654009 — immunology — Posted on 2025-05-17

2638 R2HaPpY: Rapid-robust phosphotyrosine peptide enrichment using HaloTag-Src SH2 pY superbinder

Chang, A.; Rodriguez-Mias, R. A.; Berg, M. D.; Moggridge, S.; Villen, J.

10.1101/2025.05.14.653984 — systems biology — Posted on 2025-05-17

2639 CoVET: Cryo-Electron Tomography guided by optical electrophysiology

Jung, M.; Ko, G.; Lim, D.; Kim, S.; Kim, S.; Kim, Y.-j.; Choi, M.; Roh, S.-H.

10.1101/2025.05.14.653951 — biophysics — Posted on 2025-05-17

2640 Non-destructive assessment of multi-material micro-tissue mechanics reveals the critical role of rigidity gradients in tumour growth and pressure

ALA, A.; DOUILLET, C.; FERRAND, A.; VELAY, V.; SEGONDS, S.; RECHER, G.; BUGARIN, F.

10.1101/2025.05.14.653936 — biophysics — Posted on 2025-05-17

2641 A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis

Dsouza, S.; Tersteeg, S.; Badmalia, M. D.; Chen, A.; Heck, M. S.; van Marle, G.; Corcoran, J. A.; Coffin, C. S.; Patel, T. R.

10.1101/2025.05.14.654041 — biophysics — Posted on 2025-05-17

2642 Estimation of substitution and indel rates via k-mer statistics

HERA, M. R.; Medvedev, P.; Koslicki, D.; Blanca, A.

10.1101/2025.05.14.653858 — bioinformatics — Posted on 2025-05-17

2643 Case Study of Using AI as Co-Pilot in Biotech Research: Functional Network Analysis of Invasive Cancer

Sinitskiy, A.

10.1101/2025.05.14.654152 — bioinformatics — Posted on 2025-05-17

2644 A Systems Biology Approach to Unveil Shared Therapeutic Targets and Pathological Pathways Across Major Human Cancers

ALAM, A.; Siddiqui, M. F.; Hamoudi, R. A.; Kishore, U.; Fernandez Cabezudo, M.; Al Ramadi, B.

10.1101/2025.05.14.653945 — bioinformatics — Posted on 2025-05-17

2645 Chemical inhibition of asexual development leads to increased ultimate tensile strength in mycelial material.

Gray, K.; Edwards, H.; Doan, A. G.; Huso, W.; Lee, J.; Folmer, E.; Lawrence, O.; Marten, M. R.; Harris, S. D.

10.1101/2025.05.14.653826 — bioengineering — Posted on 2025-05-17

2646 Collective unstructured interactions drive chromatin binding of transcription factors

Abidi, A. A.; Graham, T. G. W.; Dailey, G. M.; Tjian, R.

10.1101/2025.05.16.654615 — biochemistry — Posted on 2025-05-17

2647 Comprehensive degron mapping in human transcription factors

Larsen, F. B.; Voutsinos, V.; Jonsson, N.; Johansson, K. E.; Ethelberg, F. D.; Lindorff-Larsen, K.; Hartmann-Petersen, R.

10.1101/2025.05.16.654404 — biochemistry — Posted on 2025-05-17

2648 Structural evidence for metal ion catalysis in the ribosome

Hingey, J. M.; Rudolfs, B.; Haack, D. B.; Murphy, F. V.; Joseph, S.; Toor, N.

10.1101/2025.05.16.654626 — biochemistry — Posted on 2025-05-17

2649 End-product inhibition of the LRRK2-counteracting PPM1H phosphatase

Adhikari, A.; Tripathi, A.; Chiang, C. Y.; Sherpa, P. L.; Pfeffer, S. R.

10.1101/2025.05.16.654599 — biochemistry — Posted on 2025-05-17

2650 Genetic Code Expansion and Enzymatic Modifications as Accessible Methods for Studying Site-Specific Post-Translational Modifications of Alpha-Synuclein and Tau

Saleh, I. G.; Shimogawa, M.; Ramirez, J.; Abakah, B.; Venkatesh, Y.; James, H. P.; Li, M.-H.; Louie, S.; Lougee, M. G.; Chia, W.-K.; Cooley, R. B.; Mehl, R.; Baumgart, T.; Mach, R.; Eliezer, D.; Rhoades, E.; Petersson, E. J.

10.1101/2025.05.16.654576 — biochemistry — Posted on 2025-05-17

2651 Heterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment

Bulldan, A.; Zheng, M.; Meyners, C.; Purder, P.; Krieger, J.; Dreizler, J. K.; Geiger, T. M.; Repity, M.; Lein, M. H.; Lokken, I. Q.; Tewes, N.; Schwalm, M. P.; Schlesiger, S.; Moniot, S.; Knapp, S.; Hartung, I.; Holien, T.; Loewer, A.; Hausch, F.

10.1101/2025.05.16.654562 — biochemistry — Posted on 2025-05-17

2652 Selective Detection of a Key Region in Chemotaxis Signaling Protein Complexes by Solid-State NMR

Allen, J. J.; Wang, S.; Rienstra, C. M.; Thompson, L. K.

10.1101/2025.05.15.654355 — biochemistry — Posted on 2025-05-17

2653 Behavioural changes in female northern bats (Eptesicus nilssonii) across gestation and lactation.

Lilley, T.; Fjelldal, M. A.; van der Kooij, J.

10.1101/2025.05.14.653963 — animal behavior and cognition — Posted on 2025-05-17

2654 Cryptic and Ecologically Relevant Locomotor Activity Patterns in Lake Malawi Cichlids Revealed Through Computer Vision Pipeline

Holtz, N.; Lloyd, E.; Holtz, C.; Keene, A.; Albertson, C.

10.1101/2025.05.15.654275 — animal behavior and cognition — Posted on 2025-05-17

2655 LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling

Sharma, M.; Aakula, A.; Denisova, O.; Ceccacci, E.; Hayatigolkhatmi, K.; Caroli, J.; Natkin, R.; Laisne, M.-C.; Huhtaniemi, R.; Ghimire, S.; Merilahti, J.; Noberini, R.; Kamila, J.; Kauko, O.; Mattevi, A.; Bonaldi, T.; Jacquemet, G.; Nykter, M.; Minucci, S.; Westermarck, J.

10.1101/2025.05.14.653937 — genomics — Posted on 2025-05-17

2656 Genome reorganization and its functional impact during breast cancer progression

Reed, K. S. M.; Fritz, A.; Greenyer, H.; Heselmeyer-Haddad, K.; Frietze, S.; Stein, J.; Stein, G.; Misteli, T.

10.1101/2025.05.14.654144 — genomics — Posted on 2025-05-17

2657 Cell modeling and rescue of a novel non-coding genetic cause of Glycogen Storage Disease IX

Iyengar, A. K.; Zou, X.; Dai, J.; Francis, R. A.; Safi, A.; Patterson, K.; Koch, R. L.; Clarke, S.; Beaman, M. M.; Chong, J. X.; Bamshad, M. J.; Majoros, W. H.; Rehder, R. C.; Bali, D. S.; Allen, A. S.; Crawford, G. E.; Kishnani, P. S.; Reddy, T. E.

10.1101/2025.05.14.654043 — genetics — Posted on 2025-05-17

2658 Dynamics in microbial communities associated with the development of soil fatigue in banana

Cohen, D.-d.; Minz, D.; Faigenboim, A.; Elingold, I.; Sher, Y.; Galpaz, N.

10.1101/2025.05.14.653785 — ecology — Posted on 2025-05-17

2659 Impacts of oil palm plantations expansion on the distribution of terrestrial mammals in South-East Asia

Pacifici, M.; Cristiano, A.

10.1101/2025.05.14.653968 — ecology — Posted on 2025-05-17

2660 Fbxl10/Kdm2b is required for Kmt2b/Mll2 binding across thegenome and regulates H3K4 methylation on bivalent promoters

Ji, F.; Kundu, S.; Anselmo, A.; Morris, A.; Ducasse, A.; Ergun, A.; Kingston, R. E.; Sadreyev, R.

10.1101/2025.05.15.654384 — molecular biology — Posted on 2025-05-17

2661 When is microbial cross-feeding evolutionarily stable?

Lopez, J. A.; Liu, B.; Li, Z.; Donia, M. S.; Wingreen, N. S.

10.1101/2025.05.16.654511 — microbiology — Posted on 2025-05-17

2662 Modulating gene expression and protein secretion in the bacterial predator Bdellovibrio bacteriovorus

Mihajlovic, L.; Hofacker, L. M.; Lindner, F.; Jayakumar, P.; Diepold, A.; Huwiler, S. G.

10.1101/2025.05.17.654431 — microbiology — Posted on 2025-05-17

2663 Comparative Analysis of Indole Derivative Production Among Clinical Isolates of Fusobacterium nucleatum

Scano, C. J.; Choudhury, A.; Greathouse, L.; Rojo, M.; Lavado, R.; Zaharas, G.; Hawkins, J.

10.1101/2025.05.16.654558 — microbiology — Posted on 2025-05-17

2664 A novel mechanism of morphogenetic transition in Schizosaccharomyces pombe dependent on the MAPK Spc1 and the transcription factor Atf1 associated with sensing of optimal growth environment

Datta, S.; Dutta, S.; Banerjee, J.; Sundaram, G.

10.1101/2025.05.17.654634 — microbiology — Posted on 2025-05-17

2665 Lipid nanoparticle-mediated CRISPR/Cas9 delivery enables efficient trabecular meshwork gene editing in mice

Huang, Y.; Pang, S.; Li, L.; Do, C. W.; Luo, Q.; Zheng, Z.; Xiong, W.

10.1101/2025.05.17.654623 — neuroscience — Posted on 2025-05-17

2666 Mice discriminate odour source distance via sub-sniff temporal features of odour plumes

Marin, A. C.; Harris, J. J.; Dasgupta, D.; Erskine, A.; Warner, T. P. A.; Schaefer, A. T.; Ackels, T.

10.1101/2025.05.14.653752 — neuroscience — Posted on 2025-05-17

2667 Preventing light-induced toxicity in a new mouse model of rhodopsin sector retinitis pigmentosa

Guarascio, R.; Ziaka, K.; Hau, K.; Piccolo, D.; Nieuwenhuis, S. E.; Bakoulina, A.; Asfahani, R.; Aguila, M.; Athanasiou, D.; Svara, D. S.; Li, Y.; Chen, R.; Cheetham, M. E.

10.1101/2025.05.14.653774 — neuroscience — Posted on 2025-05-17

2668 Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia

Frankhouser, D. E.; Zhao, D.; Fu, Y.-H.; Dey, A.; Chen, Z.; Irizarry, J.; Rangel Ambriz, J.; Branciamore, S.; O'Meally, D.; Ghoda, L.; Trent, J.; Forman, S.; MacLean, A. L.; Kuo, Y.-H.; Zhang, B.; Rockne, R. C.; Marcucci, G.

10.1101/2025.05.14.653262 — systems biology — Posted on 2025-05-17

2669 Sequestration-Based Neural Networks That Operate Out of Equilibrium

Nakamura, E.; Britto Bisso, F.; Gispert, I.; Moghimianavval, H.; Okuda, S.; Przybyszewska-Podstawka, A.; Chisholm, S.; Hemanth Kumar, V. S.; Perez Medina, V.; Wu, M.-R.; Cuba Samaniego, C.

10.1101/2025.05.16.654484 — synthetic biology — Posted on 2025-05-17

2670 Computational design of dynamic biosensors for emerging synthetic opioids

Leonard, A. C.; Lenert-Mondou, C.; Chayer, R.; Swift, S.; Baumer, Z. T.; Delaney, R.; Friedman, A. J.; Robertson, N.; Seder, N.; Wells, J. T.; Whitmore, L.; Cutler, S.; Shirts, M. R.; Wheeldon, I.; Whitehead, T. A.

10.1101/2025.05.15.654300 — biochemistry — Posted on 2025-05-17

2671 Entry Steps in the Biosynthetic Pathway to DiterpenoidAlkaloids in Delphinium grandiflorum and Aconitum plicatum

Miller, G. P.; Mutabdzija-Nedelcheva, L.; Andersen, T.; Pascoe, I.; Van Winkle, K.; Pluskal, T.; Hamberger, B.

10.1101/2025.05.15.654307 — biochemistry — Posted on 2025-05-17

2672 SyntheMol-RL: a flexible reinforcement learning framework for designing novel and synthesizable antibiotics

Swanson, K.; Liu, G.; Catacutan, D. B.; McLellan, S.; Arnold, A.; Tu, M. M.; Brown, E. D.; Zou, J.; Stokes, J.

10.1101/2025.05.17.654017 — biochemistry — Posted on 2025-05-17

2673 One-Pot Enzymatic ADDing of Click Chemistry Handles for Protein Immobilization and Bioconjugation of Small and Biomolecules

Widodo, W. S.; Fürst, M. J. L. J.

10.1101/2025.05.17.650163 — biochemistry — Posted on 2025-05-17

2674 Non-canonical EGFR signaling is essential for MAPK-mediated apical extrusion of epithelial cells

Molina, P.; Daniel, M.; Wang, J.; MACARA, I. G.

10.1101/2025.05.16.654585 — cancer biology — Posted on 2025-05-17

2675 Out-of-equilibrium noise facilitates inference from protein sequence data

Dietler, N.; Malbranke, C.; Bitbol, A.-F.

10.1101/2025.05.14.654088 — biophysics — Posted on 2025-05-17

2676 Genome complexity, not ploidy, dictates long-read variant-calling accuracy

Fukasawa, Y.

10.1101/2025.05.14.653922 — bioinformatics — Posted on 2025-05-17

2677 Hi-Compass resolves cell-type chromatin interactions by single-cell and spatial ATAC-seq data across biological scales

Sun, Y.-C.; Jiang, W.-J.; Cai, K.-W.; Wu, H.-J.

10.1101/2025.05.14.654019 — bioinformatics — Posted on 2025-05-17

2678 A Deep Learning approach for time-consistent cell cycle phase prediction from microscopy data

Bonte, T.; Pourcelot, O.; Safieddine, A.; Slimani, F.; Mueller, F.; Weil, D.; Bertrand, E.; Walter, T.

10.1101/2025.05.16.654306 — bioinformatics — Posted on 2025-05-17

2679 DNA cross-over motifs based, programmable supramolecular hydrogels for mechanoregulatory effects of cellular behaviour and cytoskeleton reorganization

Singh, A.; Bhatia, D.

10.1101/2025.05.14.653944 — bioengineering — Posted on 2025-05-17

2680 Chromosomal fusions and subsequent rearrangements shaped octopus genomes

Yoshida, M.-a.; Toth, E.; Kon-Nanjo, K.; Kon, T.; Hirota, K.; Toyoda, A.; Toh, H.; Miyazawa, H.; Terauchi, M.; Noguchi, H.; Setiamarga, D. H.; Simakov, O.

10.1101/2025.05.16.652989 — genomics — Posted on 2025-05-17

2681 Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction

Villedieu, A.; Alegria-Prevot, O.; Phan, C.; Ieda, Y.; Corson, F.; Gros, J.

10.1101/2025.05.15.654239 — developmental biology — Posted on 2025-05-17

2682 A Conserved Domain of Cfap298 Governs Left-Right Symmetry Breaking in Vertebrates

Cortez, M.; Young, C. B.; Little, K. A.; Grimes, D. T.; Devenport, D.; Burdine, R. D.

10.1101/2025.05.16.654593 — developmental biology — Posted on 2025-05-17

2683 Arithmetic learning is associated with developmental increases in similarity between brain activity and artificial neural networks

Nakai, T.; Prado, J.

10.1101/2025.05.14.653407 — neuroscience — Posted on 2025-05-17

2684 Enhancing Biomedical Optical Volumetric Imaging via Self-Supervised Orthogonal Learning

Gu, Y.; Wang, Y.; Xuan, A.; Wang, J.; Wang, L.; Zhang, L.; Li, X.; Wu, Y.; Zhang, J.; Lu, Z.; Dong, B.

10.1101/2025.05.16.654259 — neuroscience — Posted on 2025-05-17

2685 Improving proteomic dynamic range with Multiple Accumulation Precursor Mass Spectrometry (MAP-MS)

Phlairaharn, T.; Shannon, A. E.; Zeng, X.; Truong, D.-J. J.; Schoof, E. M.; Ye, Z.; Searle, B. C.

10.1101/2025.05.14.653938 — biochemistry — Posted on 2025-05-17

2686 Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish

Balciunas, D.; Kalvaityte-Repecke, M.; Gabrilaviciute, S.; Kvederaviciute, K.; Bakunaite, E.; Burg, L.; Poss, K. D.

10.1101/2025.05.15.654216 — developmental biology — Posted on 2025-05-17

2687 Distinct Sox9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids

Walther, N.; Anantakrishnan, S.; Dailey, G. M.; Maurer, A. C.; Cattoglio, C.

10.1101/2025.05.16.654343 — developmental biology — Posted on 2025-05-17

2688 Selective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States

Wang, D.; Wang, X.; Wang, S.; Shi, K.-X.; Malki, S.; Chan, Y.; Feng, J.; Tang, J.; Chen, X.; McKim, D.; Zhang, C.; Hu, G.; Ying, Q.-L.

10.1101/2025.05.16.653860 — cell biology — Posted on 2025-05-17

2689 The temporal and perceptual characteristics of emotion-induced blindness

Alarie, M. E.; Yang, G. H.; Quinn, L. R.; Lin, T.; Asaad, W. F.

10.1101/2025.05.15.653853 — neuroscience — Posted on 2025-05-17

2690 Visual analytics framework for survival analysis and biomarker discovery

Kokosar, J.; Turkay, C.; Avsec, L.; Stajdohar, M.; Zupan, B.

10.1101/2025.05.14.654136 — bioinformatics — Posted on 2025-05-17

2691 STARTER : A Stand-Alone Reconfigurable and TranslationalOoC Platorm based on Modularity and Open Design Principles

Paul, A.; Safai, E. R.; de Heus, L.; Vollertsen, A. R.; Weijgertse, K.; de Wagenaar, B.; Amirabadi, H. E.; van de Steeg, E.; Odijk, M.; van der Meer, A.; Loessberg-Zahl, J.

10.1101/2025.05.13.653800 — bioengineering — Posted on 2025-05-17

2692 Risk assessment for condylar stress fracture in elite racing Thoroughbreds using standing computed tomography-based virtual mechanical testing

Brown, N.; Irandoust, S.; Thom, E. J.; Whitton, R. C.; Henak, C.; Muir, P.

10.1101/2025.05.13.653480 — bioengineering — Posted on 2025-05-17

2693 A polygon model of the functional base-of-support improves the accuracy of balance analysis

Millard, M.; Sloot, L. H.

10.1101/2025.05.13.653782 — bioengineering — Posted on 2025-05-17

2694 Social evaluation of skilfulness in Tonkean macaques (Macaca tonkeana) and brown capuchins (Sapajus apella)

Hirel, M.; Marziliano, M.; Meunier, H.; Rakoczy, H.; Fischer, J.; Keupp, S.

10.1101/2025.05.13.653791 — animal behavior and cognition — Posted on 2025-05-17

2695 The insidious degeneration of white matter and cognitive decline in Fabry disease

Johnson, J. W.; Baradaran, H.; Morgan, J.; Odeen, H.; Friel, E.; Bailey, C.; Zielinski, B. A.; Underhill, H. R.

10.1101/2025.05.14.654139 — genetics — Posted on 2025-05-17

2696 When should adaptation arise from a polygenic response versus few large effect changes?

Milligan, W. R.; Hayward, L. K.; Sella, G.

10.1101/2025.05.15.654234 — evolutionary biology — Posted on 2025-05-17

2697 Global motor system suppression as the primary mechanism of human action stopping: challenging the pause-then-cancel model

Chaudhuri, E. R.; Long, T.; Hannah, R.

10.1101/2025.05.13.653703 — neuroscience — Posted on 2025-05-17

2698 Hypoxia and Cognitive Ability in Humans: A Systematic Review and Meta-Analysis

Mckeown, D. J.; Angus, D. J.; Moustafa, A. A.; Schinazi, V. R.

10.1101/2025.05.15.654374 — neuroscience — Posted on 2025-05-17

2699 Optimising fertilisation kinetics models for broadcast spawning corals in the genus Acropora

Buccheri, E.; Babcock, R. C.; Mumby, P. J.; Doropoulos, C.; Ricardo, G. F.

10.1101/2025.05.13.653772 — systems biology — Posted on 2025-05-17

2700 Review: Estimates of livestock genetic diversity in the UK

Rochus, C. M.; Price, C. F.; Pocrnic, I.

10.1101/2025.05.14.653764 — genetics — Posted on 2025-05-17

2701 Nutritional effects on the expression of cryptic pigmentation in freshwater isopods

Lurig, M. D.; Matthews, B.; Schubert, C. D.; Kishida, O.

10.1101/2025.05.13.653594 — ecology — Posted on 2025-05-17

2702 When your heart isn't in it anymore: Cardiac correlates of task disengagement

Corcoran, A. W.; Le Coz, A.; Hohwy, J.; Andrillon, T.

10.1101/2024.06.21.599851 — neuroscience — Posted on 2025-05-17

2703 Volitional and forced running ability in mice lacking intact primary motor cortex

Abo, R.; Ishikawa, M.; Shinohara, R.; Michikawa, T.; Imayoshi, I.

10.1101/2025.05.14.653913 — neuroscience — Posted on 2025-05-17

2704 Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance

Amouyal, C.; Chen, S. P.; Denom, J.; Raho, I.; Kassis, N.; Diedisheim, M.; Mifsud, F.; Lallement, J.; Georgiadou, E.; Ibberson, M.; Croyal, M.; Jiang, X.-C.; CRUCIANI-GUGLIELMACCI, C.; Le Stunff, H.; Rutter, G. A.; Magnan, C.

10.1101/2025.05.14.653935 — physiology — Posted on 2025-05-17

2705 Pervasive homeobox gene function in the male-specific nervous system of Caenorhabditis elegans

Fernandez, R. W.; Digirolamo, A. J.; Valperga, G.; Aguilar, G. R.; Molina-Garcia, L.; Kersh, R. M.; Wang, C.; Pe, K.; Ramadan, Y. H.; Loer, C.; Barrios, A.; Hobert, O.

10.1101/2025.05.13.653874 — neuroscience — Posted on 2025-05-17

2706 sKL/mKL Transcript Ratio and Protein Localization Define a Species- and Region-Specific Klotho Signature in the CNS and AD Progression

Blanch, R.; Esandi, J.; Guerrero-Yagüe, R.; Del Rey, J.; Roig-Soriano, J.; Lleo, A.; Carro, E.; Mestre-Frances, N.; Devau, G.; Ferrer, I.; Meseguer, A.; Lanciego, J. L.; Almolda, B.; Bosch, A.; Chillon, M.

10.1101/2025.05.13.653838 — neuroscience — Posted on 2025-05-17

2707 ProtFun: A Protein Function Prediction Model Using Graph Attention Networks with a Protein Large Language Model

Talo, M.; Bozdag, S.

10.1101/2025.05.13.653854 — bioinformatics — Posted on 2025-05-17

2708 Co-Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Jones, S.; Laude, M.; Oyebanji, Z.; Birur, R.; Luengo Martinez, A.; Gilbert, I.; Baek, P.; Cosgriff-Hernandez, E.

10.1101/2025.05.13.653533 — bioengineering — Posted on 2025-05-17

2709 PhaseGen: Exact Solutions for Time-Inhomogenous Multivariate Coalescent Distributions under Diverse Demographies

Sendrowski, J.; Hobolth, A.

10.1101/2025.05.13.653888 — genetics — Posted on 2025-05-17

2710 Evolutionary dynamics of gene and isoform regulation underlying rapid and parallel adaptive radiations

Singh, P.

10.1101/2025.05.13.653813 — evolutionary biology — Posted on 2025-05-17

2711 Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury

Sharma, B.; Rehman, H.; Lu, X.; Figueiredo, V. C.; Van Remmen, H.; Kuang, S.; Brooks, S. V.; Davis, C.; Maddipati, K. R.; Markworth, J. F.

10.1101/2025.05.13.653766 — developmental biology — Posted on 2025-05-17

2712 Chronic compression drives macrophages toward a pathological pro-tumor state

Burchett, A.; chen, H.; Najera, J.; Howard, S.; Datta, M.

10.1101/2025.05.13.653793 — immunology — Posted on 2025-05-17

2713 Macrophage migration inhibitory factor is a potential therapeutic target for cisplatin induced peripheral neuropathy in breast cancer

El-Baroudy, H.; Delgadillo, X. M.; Bamania, N.; Sivakumar, B.; Dwivedi, S.; Chowdhury, B.; Joseph, N.; Pathak, S.; Mizkus, S.; Ahmed, S.; Krishnan, A.

10.1101/2025.05.13.653890 — neuroscience — Posted on 2025-05-17

2714 Dibutyryl cyclic AMP downregulates tenascin-C in neurons and astrocytes and reduces AAV-mediated gene expression in DRG neurons

Stepankova, K.; Cimpean, A.; Smejkalova, B.; Holota, R.; Bachanova, L.; Cerny, J.; Sprincl, V.; Marekova, D.; van den Herik, J.; de Winter, F.; Jendelova, P.; Urdzikova, L. M.

10.1101/2025.05.13.653846 — neuroscience — Posted on 2025-05-17

2715 Progressive neural engagement within the IFG-pMTG circuit as gesture and speech entropy and MI advances

Zhao, W.; Li, Z.; Li, X.; Du, Y.

10.1101/2022.11.23.517759 — neuroscience — Posted on 2025-05-17

2716 Phosphorus Bioaccessibility of Processed Soy and Pulse Protein Products Measured by In Vitro Simulation of Human Digestion

Burstad, K. M.; Fons, A.; Kisch, A. R.; Cladis, D. P.; Hill Gallant, K. M.

10.1101/2025.05.13.653545 — physiology — Posted on 2025-05-17

2717 Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice

Bruner, K. R.; Byington, I. R.; Marx, T. J.; Vasileva, A.; Fletcher, T.; Ghimire, S.; Zappia, I. J.; Shaju, Y.; Zeng, J.; Wachsmuth, H. R.; Carlyon, T.; Besselsen, D. G.; Drucker, D. J.; Duca, F. A.; Stern, J. H.

10.1101/2025.05.13.653849 — physiology — Posted on 2025-05-17

2718 CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids

Nada, H.; Zhang, L.; Kaur, B.; Gabr, M.

10.1101/2025.05.13.653859 — pharmacology and toxicology — Posted on 2025-05-17

2719 A novel bioinformatics approach reveals key transcription factors regulating type 1 diabetes-associated transcriptomes

Sheikh, A.; Parvin, S.; Dipto, S.; Hossain, S.

10.1101/2025.05.13.653885 — bioinformatics — Posted on 2025-05-17

2720 Translation Efficiency Impacts Phage Lysis Timing and Its Precision in Single Cells

Kannoly, S.; Singh, K.; Juman, N.; Islam, Z. M.; Caballero Quiroga, I.; Singh, A.; Dennehy, J. J.

10.1101/2025.05.14.654169 — microbiology — Posted on 2025-05-17

2721 Bridging Gaps in Soil Ecology: Metagenomic Insights into Microbial Diversity and Functionality Across Brazil's Biomes.

Tacca, L. M. A.; Lima, R. N.; Pascoal, P. V.; de Oliveira, M. A.; de Azevedo, C. A. X.; Bambil, D.; Mizotte, P.; Rosinha, G. M. S.; Bittencourt, D. M. d. C. B. M. d. C.; Signor, D.; de Moura, M. S. B.; Trindade, J. P. P.; Volk, L. B. d. S.; Fernandes, F. A.; Lopes, R.; Simoes-Araujo, J. L.; Freire, M.; Rech, E.

10.1101/2025.05.16.654316 — microbiology — Posted on 2025-05-17

2722 Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Tang, E.; Hu, Y.; Cao, G.; Asby, N. W.; Nguyen, D.-T.; Aboelella, N. S.; Ruiz, H.; Zhao, Y.; Xie, L.; Chen, X.; Bishop, M. R.; Riedell, P. A.; LaBelle, J. L.; Kline, J. P.; Huang, J.

10.1101/2025.05.13.653878 — immunology — Posted on 2025-05-17

2723 See-through science: Danionella cerebrum as a model for neuroregeneration

Misyuk, M. K.; Austin, J. L.; Walechka, N. R.; Peterka, J. A.; Veldman, M. B.; Lam, P.-Y.

10.1101/2025.05.13.653880 — neuroscience — Posted on 2025-05-17

2724 Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy

Kinch, C. D.; Kesler, M.; Dogra, D. D.; Morin, K.; Ibhazehiebo, K.; Noschang, C. G.; Rho, J. M.; Kurrasch, D.

10.1101/2025.05.13.653835 — neuroscience — Posted on 2025-05-17

2725 Characterising the neural time-courses of food attribute representations

Chae, V. J.; Grootswagers, T.; Bode, S.; Feuerriegel, D.

10.1101/2025.05.13.653572 — neuroscience — Posted on 2025-05-17

2726 Direct interoceptive input to the insular cortex shapes learned feeding behavior

Zhao, Z.; Xu, B.; Anthony, S.; Subramanian, S.; Granger, B.; Von-Walter, C.; Mizrachi, E.; Kidd, M.; Srigiriraju, A.; McKie, I.; Li, Z.; Bolton, M. M.; Berto, S.; Stern, S. A.

10.1101/2025.05.13.653896 — neuroscience — Posted on 2025-05-17

2727 Visual Field Inhomogeneities Shape Visual Working Memory

Papiernik-Kłodzinska, J.; Del Pin, S. H.; Wierzchon, M.; Carrasco, M.; Rutiku, R.

10.1101/2025.05.13.653695 — neuroscience — Posted on 2025-05-17

2728 Fast barcode calling based on k-mer distances

Uphoff, R. C.; Schueler, S.; Grosse, I.; Mueller-Hannemann, M.

10.1101/2025.05.12.653416 — bioinformatics — Posted on 2025-05-17

2729 Three-dimensional genome architecture connects chromatin structure and function in a major wheat pathogen

Glavincheska, I.; Lorrain, C.

10.1101/2025.05.13.653796 — genomics — Posted on 2025-05-17

2730 Five new Caenorhabditis species from Indonesia provide exceptions to Haldane's rule and partial fertility of interspecific hybrids

Devi, M. P.; Haryoso, E.; Rais, E. I.; Karuniawan, A.; Yahya, M. Q.; Richaud, A.; Wang, J.; Rockman, M. V.; Tarno, H.; Felix, M.-A.

10.1101/2025.05.14.653126 — genetics — Posted on 2025-05-17

2731 Divergent photosynthesis and leaf respiration responses of four common subtropical tree species to modest warming

Hussain, K.; Bakpa, E. P.; Ning, Q.; Huang, S.; Mustafa, A.; Ma, Q.; Liu, H.

10.1101/2025.05.13.653929 — ecology — Posted on 2025-05-17

2732 Elephants inhabiting two forested sites in western Uganda exhibit contrasting patterns of species identity, density, and history of hybridization

Goodfellow, C. K.; Chusyd, D. E.; Bird, S. R.; Babaasa, D.; Chapman, C. A.; Hickey, J. R.; Johnson, M. B.; Kayijamahe, C.; Mutegeki, R.; Omeja, P. A.; Tumwesigye, C.; Uzabaho, E.; Wasser, S. K.; Wasserman, M. D.; Wells, C. P.; Ting, N.

10.1101/2025.05.13.653790 — ecology — Posted on 2025-05-17

2733 F-53B damages cell viability leading to impaired root development in Arabidopsis

Zhao, J.; Pan, W.; Chen, Y.; Cui, X.; Fu, H.; Luo, Y.; Chen, Z.; Huang, N.; Hu, Y.; Qin, Y.; Yu, G.; Ren, Z.; Wang, W.; Lei, X.; Liu, B.

10.1101/2025.05.13.653422 — developmental biology — Posted on 2025-05-17

2734 Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors

Bekere, I.; Rob, S.; Lübbe, J.; Kulnik, S.; Berneking, L.; Huang, J.; Schnapp, M.; Diercks, B.-P.; Carsten, A.; Ruckdeschel, K.; Aepfelbacher, M.

10.1101/2025.05.12.653505 — cell biology — Posted on 2025-05-17

2735 Insights from aquaporin structures into drug-resistant sleeping sickness

Matusevicius, M.; Corey, R. A.; Gragera, M.; Yamashita, K.; Sprenger, T.; Ungogo, M.; Blaza, J. N.; Castro-Hartmann, P.; Chirgadze, D. Y.; Chaitanya Vedithi, S.; Afanasyev, P.; Melero, R.; Warshamanage, R.; Gusach, A.; Carazo, J.-M.; Carrington, M.; Blundell, T.; Murshudov, G. N.; Stansfeld, P. J.; Sansom, M. S.; De Koning, H. P.; Tate, C. G.; Weyand, S.

10.1101/2025.05.15.654314 — molecular biology — Posted on 2025-05-17

2736 PqsE is conserved and functionally relevant in Pseudomonas aeruginosa

Trottier, M.; Groleau, M.-C.; Gauthier, J.; Vincent, A. T.; Levesque, R. C.; Deziel, E.

10.1101/2025.05.16.654539 — microbiology — Posted on 2025-05-17

2737 First report of Photobacterium damselae subspecies damselae in Razorbill (Alca torda)

Minichino, A.; Lucibelli, F.; Guardia, T.; Balestrieri, R.; Aceto, S.; Vaccaro, E.; Dipineto, L.; Sapio, M.; Santaniello, A.; De Luca Bossa, L. M.; D Alessio, N.; Fioretti, A.; Borrelli, L.

10.1101/2025.05.15.654261 — microbiology — Posted on 2025-05-17

2738 Bi-directional relationship between the biofilm of Porphyromonas gingivalis and the amyloid-beta peptide.

Dumoulin, D.; Ghrayeb, M.; Cote, S.; Garneau, D.; Chai, L.; Frost, E.; Fülöp, T.; Beauregard, P. B.

10.1101/2025.05.16.654480 — microbiology — Posted on 2025-05-17

2739 Wolbachia uses ankyrin repeats to target specific fly proteins

Hamilton, W. C.; Massey, J.; Hardy, E.; Lopez-Madrigal, S.; Phelps, M.; Martin, M.; Newton, I. L. G.

10.1101/2025.05.15.654400 — microbiology — Posted on 2025-05-17

2740 Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing

Mahdy, A. K. H.; ElAbd, H.; Prinzensteiner, M.; Jebens, H.; Sivickis, K.; Bacher, P.; Vogl, T.; Poyet, M.; Franke, A.

10.1101/2025.05.13.653535 — immunology — Posted on 2025-05-17

2741 Interferon-β paracrine signaling mediates synergy between TLR3 and TRIF-independent TLR pathways

Rocha, E. I. S.; Samo, K.; Miller-Jensen, K.

10.1101/2025.05.13.653801 — immunology — Posted on 2025-05-17

2742 AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

Chaigne, S.; Hof, T.; Mimoun, K.; El Ghebouli, A.; Charron, S.; Brette, F.; Choveau, F.; Pasdois, P.; Rucker-Martin, C.; Benoist, D.; Guinamard, R.; Haissaguerre, M.; Walton, R.; Bernus, O.

10.1101/2025.05.13.653917 — physiology — Posted on 2025-05-17

2743 Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells

Braband, K. L.; Kaufmann, T.; Beumer, N.; Simon, M.; Helbich, S. S.; Mihoc, D. M.; Voss, M. M.; Nedwed, A. S.; Bauer, K.; Mallm, J.-P.; Ziesmann, T.; Distler, U.; Tenzer, S.; Eckert, C.; Volkmar, M.; Weichenhan, D.; Baehr, M.; Plass, C.; Linke, M.; Diederich, S.; Klein, M.; Bopp, T.; Schild, H.; Henkel, A.; Filippi, E.; Marini, F.; Brors, B.; Gaida, M. M.; Delacher, M.

10.1101/2025.05.14.653926 — immunology — Posted on 2025-05-17

2744 Developmental factors drive the compartmentalised and discontinuous maturation of the small intestinal epithelium during the early postnatal period

Schöneich, J.; Dupont, A.; Schlösser, S.; Schmitz, M. A.; Richter, I.; Gubbi, N. M. K. P.; Cheng, M.; Maie, T.; Jäverfelt, S.; Imdahl, F.; Toussaint, C.; Saliba, A.-E.; Kuppe, C.; Pelaseyed, T.; Costa, I. G.; Hornef, M. W.

10.1101/2025.05.15.654215 — immunology — Posted on 2025-05-17

2745 Structural variants are enriched for molecular QTL in a cattle long read cohort

Mapel, X. M.; Leonard, A. S.; Pausch, H.

10.1101/2025.05.16.654493 — genetics — Posted on 2025-05-16

2746 Directional alignment of different cell types organizes planar cell polarity

Arata, M.; Koyama, H.; Fujimori, T.

10.1101/2025.05.13.653899 — developmental biology — Posted on 2025-05-16

2747 Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids

Ryu, S.; Inman, J.; Hong, H.; Jovanovic, V. M.; Gedik, Y.; Jethmalani, Y.; Hur, I.; Voss, T.; Lack, J.; Collins, J.; Ormanoglu, P.; Simeonov, A.; Tristan, C. A.; Singe"c", I.

10.1101/2025.05.16.654315 — developmental biology — Posted on 2025-05-16

2748 Neural signatures of predictive coding underlying the acquisition of incidental sensory associations

Greco, A.; Rastelli, C.; Bonetti, L.; Braun, C.; Caria, A.

10.1101/2025.05.16.654429 — neuroscience — Posted on 2025-05-16

2749 Basolateral amygdala dopamine transmits a nonassociative emotional salience signal

Brickner, M. A.; Szot, W. E.; Wolff, A. R.; Thomas, M. J.; Saunders, B. T.

10.1101/2025.05.15.654323 — neuroscience — Posted on 2025-05-16

2750 Geometric principles of dendritic integration of excitation and inhibition in cortical neurons

Darvish-Ghane, S.; Gaur, P.; Ellis-Davies, G.

10.1101/2025.05.16.654465 — neuroscience — Posted on 2025-05-16

2751 Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh Syndrome mice

Biswas, S. R.; Tomsick, P. L.; Kelly, C.; Lester, B. A.; Milner, J. P.; Henry, S. N.; Soto, Y.; Brindley, S.; DeFoor, N.; Morton, P. D.; Pickrell, A. M.

10.1101/2025.05.16.654318 — neuroscience — Posted on 2025-05-16

2752 Multimodal cortical connectome in the default mode network across the adult lifespan

Wang, S.; Liu, X.; He, J.; chang, x.; yu, q.; Wan, B.; Liu, Z.; Mi, W.-f.; Shi, L.

10.1101/2025.05.16.654309 — neuroscience — Posted on 2025-05-16

2753 Early development of direction selectivity in higher visual cortex

Khamiss, D. C.; Lempel, A. A.; Nanfito, B. R.; Nielsen, K. J.

10.1101/2025.05.15.654265 — neuroscience — Posted on 2025-05-17

2754 Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

Zhu, X.; John, A. J.; Wang, L.; Kim, S.; Ding, E.; Saleh, A.; Marin-Goni, I.; Jomaa, A.; Gao, H.; Wai, C. M.; Moon, I.; Coombes, B. J.; Kerr, T. M.; Suto, N.; Wang, L.; Frye, M. A.; Biernacka, J. M.; Karpyak, V. M.; Li, H.; Weinshilboum, R. M.; Liu, D.

10.1101/2025.05.15.654319 — genomics — Posted on 2025-05-16

2755 NUSAP1 regulates mitotic processes via KIF2C interaction and AURKA phosphorylation in primary microcephaly

Ren, D.; Li, K.; Liu, C.; Bi, Y.; Liu, L.; Ji, L.; Yang, K.; Luo, Y.; Luo, L.; Yan, Y.; Li, Y.; Yang, F.; Wang, H.; He, G.; Mao, X.

10.1101/2025.05.16.654427 — genetics — Posted on 2025-05-16

2756 Comparison of oral and gut microbiome highlights role of oral bacteria in systemic inflammation in HIV

Fulcher, J. A.; Newman, K.; Pham, B.; Li, F.; Cho, G. D.; Elliott, J.; Tobin, N. H.; Shoptaw, S.; Gorbach, P. M.; Aldrovandi, G. M.

10.1101/2025.05.16.654362 — microbiology — Posted on 2025-05-16

2757 Old mice have a functionally distinct contractile reserve from obese mice

Sturgill, S. L.; Aidja, M.; Hu, B.; Ziolo, M. T.

10.1101/2025.05.13.653770 — physiology — Posted on 2025-05-16

2758 Cell shapes decode molecular phenotypes in image-basedspatial proteomics

Le, T.; Leineweber, W. D.; Viana, M. P.; Cesnik, A.; Hansen, J. N.; Ouyang, W.; Rafelski, S. M.; Lundberg, E.

10.1101/2025.05.13.653868 — bioengineering — Posted on 2025-05-16

2759 The Critical Role of the C-terminal Lobe of Calmodulin in Activating Eukaryotic Elongation Factor 2 Kinase

Long, K. J.; Browning, L. S.; Piserchio, A.; Isiorho, E. A.; Gadallah, M.; Douangvilay, J.; Wang, E. Y.; Kalugin, J. K.; Brodbelt, J. S.; Ghose, R.; Dalby, K. N.

10.1101/2025.05.13.653565 — biochemistry — Posted on 2025-05-16

2760 Synergistic Action of Commercial Lipase, Lipoxygenases and Proteinase towards PLA Depolymerization

Salini, A.; Gonnelli, P.; Padoan, C.; Helali, Y.; Waeytens, J.; Fusco, S.; Cannella, D.

10.1101/2025.05.13.653912 — biochemistry — Posted on 2025-05-16

2761 Sequence based prediction of cell type specific microRNA binding and mRNA degradation for therapeutic discovery

Kanuparthi, B.; Pour, S. E.; Findlay, S. D.; Wagih, O.; Gutierrez, J. M.; Gao, R.; Wintersinger, J.; Lin, J.; Gabra, M.; Bohn, E.; Lau, T.; Cole, C. B.; Jung, A.; Celaj, A.; Soares, F.; Gray, R.; Vaz, B.; Delfosse, K.; Lodaya, V.; Bhargava, S.; Ly, D.; Yusuf, F.; Kron, K.; Hoffman, G.; Gandhi, S.; Frey, B. J.

10.1101/2025.05.15.654105 — genomics — Posted on 2025-05-16

2762 Biophysical Modeling Uncovers Transcription Factor and Nucleosome Binding on Single DNA Molecules

Dalakishvili, L.; Managori, H.; Bardet, A.; Slaninova, V.; Bertrand, E.; Molina, N.

10.1101/2025.05.13.653852 — genomics — Posted on 2025-05-16

2763 The transcriptomics of phenotypic nonspecificity in Drosophila melanogaster

Sidhu, G. A.; Percival-Smith, A.

10.1101/2025.05.13.653887 — genetics — Posted on 2025-05-16

2764 AI-Enhanced Marker-Assisted Selection Concept for The Multifunctional Honey Bee (Hymenoptera: Apidea) Protein Vitellogenin (Vg)

Leipart, V.; Amdam, G. V.; O'Brien, S.; Pigott, E.; Dodds, G.; Ihle, K.

10.1101/2025.05.13.653757 — genetics — Posted on 2025-05-16

2765 PhylloTraits 1.0: Unveiling the diversity of functional traits

Villalobos, F.; Saldana-Vazquez, R. A.; Azofeifa-Romero, Y.; Pineda-Lizano, W.; Sanchez, M. S.; Ayala-Berdon, J.; Carballo-Morales, J. D.; Castano, J. H.; Hernandez-Montero, J. R.; Herrera-Alsina, L.

10.1101/2025.05.13.653771 — ecology — Posted on 2025-05-16

2766 Bile acids target an exposed cavity in the glucocorticoid receptor modulating receptor self-assembly, chromatin binding and transcriptional activity

Jimenez-Panizo, A.; Johnson, T. A.; Wagh, K.; Alegre-Marti, A.; Montoya-Novoa, I.; Lafuente, A. L.; Eckhard, U.; Rodriguez-Lumbreras, L. A.; Hoang, L.; Stortz, M.; Abella, M.; Goldstein, I.; Valledor-Fernandez, A.; Varticovski, L.; Arias, I.; Presman, D. M.; Stavreva, D. A.; Fernandez-Recio, J.; Fuentes-Prior, P.; Hager, G. L.; Estebanez-Perpina, E.

10.1101/2025.05.13.653693 — molecular biology — Posted on 2025-05-16

2767 Protocol for the development and use of spike-in control for chromatin immunoprecipitation (ChIP) of chromatin-binding proteins

Khanduja, J. S.; Motamedi, M.

10.1101/2025.05.13.653544 — molecular biology — Posted on 2025-05-16

2768 Model-independent reorganization of translation in TDP-43 Amyotrophic Lateral Sclerosis

Lauria, F.; Maniscalco, F.; Perrucci, C.; Marchioretto, M.; Bruno, I.; Tome, G.; Cella, F.; Busarello, E.; Sevegnani, M.; Lunelli, L.; Donini, L.; Tebaldi, T.; D Antoni, M.; Pollini, D.; Peroni, D.; Pisciottani, A.; Croci, L.; Badaloni, A.; Arnese, R.; Provenzani, A.; Quattrone, A.; Consalez, G. G.; Clamer, M.; Siciliano, V.; Basso, M.; Viero, G.

10.1101/2025.05.15.654227 — molecular biology — Posted on 2025-05-16

2769 Exercise Related microRNAs in C. elegans Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs

Xia, Q.; Tang, J.; Casas-Martinez, J. C.; Li, P.; Quinlan, L. R.; Goljanek-Whysall, K.; McDonagh, B.

10.1101/2025.05.13.653755 — molecular biology — Posted on 2025-05-16

2770 The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes

Odai, R.; Leemann, M.; Al-Murad, T.; Abdullah, M.; Shyrokova, L.; Tenson, T.; Hauryliuk, V.; Durairaj, J.; Pereira, J.; Atkinson, G. C.

10.1101/2025.05.14.653371 — molecular biology — Posted on 2025-05-16

2771 Efficient CRISPR-Cas9-mediated genome editing of the cane toad (Rhinella marina)

Clark, M.; Funk, A.; Paporakis, A.; Brown, G. P.; Beach, S. J.; Tay, A.; Deering, S.; Cooper, C.; Tizard, M.; Jolly, C. J.; Ward-Fear, G.; Waddle, A. W.; Shine, R.; Maselko, M.

10.1101/2025.05.15.654396 — synthetic biology — Posted on 2025-05-16

2772 A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

Palou, R.; van der Sloot, A. M.; Fiebig, A. A.; Zangara, M. T.; Sangwan, N.; Sanchez-Osuna, M.; Ilyas, B.; Zubyk, H.; Cook, M.; Wright, G. D.; Coombes, B. K.; Tyers, M.

10.1101/2025.05.15.652971 — synthetic biology — Posted on 2025-05-16

2773 Experimental Evaluation of AI-Driven Protein Design Risks Using Safe Biological Proxies

Ikonomova, S. P.; Wittmann, B. J.; Piorino, F.; Ross, D. J.; Schaffter, S. W.; Vasilyeva, O. B.; Horvitz, E.; Diggans, J.; Strychalski, E. A.; Lin-Gibson, S.; Taghon, G. J.

10.1101/2025.05.15.654077 — synthetic biology — Posted on 2025-05-16

2774 The NHEJ machinery is translocated off DNA ends toenable resection

Sathyanarayana, P.; Wu, Y.; Walter, J. C.; Loparo, J. J.

10.1101/2025.05.13.653820 — biophysics — Posted on 2025-05-16

2775 Structure-based identification of GIRK2-PIP2 modulators among known drugs and metabolites using docking, MM-GBSA, ADMET, and molecular dynamics

Jeremic, D.; Jimenez-Diaz, L.; Navarro-Lopez, J. D.

10.1101/2025.05.13.653795 — bioinformatics — Posted on 2025-05-16

2776 Fibronectin Composition and Transglutaminase 2 Cross-linking Cooperatively Regulate Ovarian Cancer Cell Adhesion in ECM-Mimetic Constructs

Yang, N.; Abbaspour, A.; Considine, J. M.; McGregor, S. M.; Brooks, E. G.; Naba, A.; Masters, K. S.; Kreeger, P. K.

10.1101/2025.05.13.653765 — bioengineering — Posted on 2025-05-16

2777 Quantification of disease-associated RNA tandem repeats by nanopore sensing

Patino-Guillen, G.; Pesovic, J.; Panic, M.; Earle, M.; Ninkovic, A.; Petrusca, S.; Savic-Pavicevic, D.; Keyser, U. F.; Boskovic, F.

10.1101/2025.05.15.653973 — biochemistry — Posted on 2025-05-16

2778 Adaptation of the Chlorella photosynthetic electron transport chain to environmental light conditions

Steiner, G.; Saini, D.; Kapoor, A.; Gates, C.

10.1101/2025.05.13.653806 — biochemistry — Posted on 2025-05-16

2779 Mitochondrial Genome of the lesser known - Madras Hedgehog (Paraechinus nudiventris): Genomic characterization and comparative analysis within Erinaceidae

Vijayan, T.; Meimberg, H.; Kumar, B.

10.1101/2025.05.13.653780 — genomics — Posted on 2025-05-16

2780 Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies

Mullis, M. N.; Lefebvre, A. E. Y. T.-S.; Sivasubramanian, K.; Luo, A.; Schmid, F.; Sooknah, M.; Wright, K. M.; Raj, A.; Zavala-Solorio, J.; Zhang, C.; Riegler, J.; Gillich, A.; Ruby, J. G.

10.1101/2025.05.13.653808 — genetics — Posted on 2025-05-16

2781 Structure of YbbAP-TesA: a Type VII ABC transporter lipid-hydrolase complex

McAndrew, M. B.; Cook, J.; Gill, A.; Sahoo, K.; Thomas, C.; Stansfeld, P. J.; Crow, A.

10.1101/2025.05.16.654284 — microbiology — Posted on 2025-05-16

2782 Prolonged non-suppressible viremia sustained by a clonally expanded, genomically defective provirus with an immune-evasive HIV protein expression profile

Omondi, F. H.; Sang, Y.; Mwimanzi, F.; Cheung, P. K.; Derza, Z.; Dong, W.; Barad, E.; Anderson, K.; Mysak, V.; Lima, V. D.; Hull, M.; Brumme, C. J.; Harris, M.; Montaner, J. S. G.; Guillemi, S.; Brockman, M. A.; Brumme, Z. L.

10.1101/2025.05.16.654538 — microbiology — Posted on 2025-05-16

2783 Amplification-free Detection of Zoonotic Viruses Using Cas13 and Multiple CRISPR RNAs

Lamb, C.; te Velthuis, A. J. W.; Myhrvold, C.; Nilsson-Payant, B.

10.1101/2025.05.15.654407 — microbiology — Posted on 2025-05-16

2784 Bioelectricity generation by Symbiodinium microadriaticum: a symbiont-forming photosynthetic dinoflagellate alga from coral reefs

Marcel, L.; Simon, J. T.; Lawrence, J. M.; Menkin, S.; Barbrook, A. C.; Nisbet, R. E. R.; Howe, C. J.; Zhang, J. Z.

10.1101/2025.05.16.654495 — microbiology — Posted on 2025-05-16

2785 Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design

He, L.; Lee, Y.-Z.; Zhang, Y.; Newby, M. L.; Janus, B. M.; Gonzalez, F. G.; Ward, G.; DesRoberts, C.; Hung, S.-H.; Giang, E.; Allen, J. D.; Kulakova, L.; Toth, E. A.; Fuerst, T.; Law, M.; Ofek, G.; Crispin, M.; Zhu, J.

10.1101/2025.05.16.654559 — microbiology — Posted on 2025-05-16

2786 CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition

Rijal, S.; Standage-Beier, K.; Zhang, R.; Stone, A.; Youssef, A.; Wang, X.; Tian, X.

10.1101/2025.05.15.654351 — synthetic biology — Posted on 2025-05-16

2787 Poxvirus targeted by RFdiffusion peptide-binders

Coll, J. M.

10.1101/2025.05.14.654163 — bioinformatics — Posted on 2025-05-16

2788 A Graph-Attention-Based Deep Learning Network for Predicting Biotech-Small-Molecule Drug Interactions

Nasiri, F.; Hooshmand, M.

10.1101/2025.05.13.653666 — bioinformatics — Posted on 2025-05-16

2789 PEPlife2: A Updated Repository of the Half-life of Peptides

Alam, U.; Chaudhary, K.; Kumar, N.; Tomer, R.; Patiyal, S.; Raghava, G. P. S.

10.1101/2025.05.13.653654 — bioinformatics — Posted on 2025-05-16

2790 MSH3 is a genetic modifier of somatic repeat instability in X-linked dystonia parkinsonism

MAZA, A. M.; Hincher, M.; Correia, K.; Gillis, T.; Nishiyama, A.; Penney, E. B.; Domingo, A.; Yadav, R.; Murcar, M. G.; Mercado, P.; Han, J. S.; Norenberg, E. P.; Fernandez-Cerado, C.; Legarda, G. P.; Sy, M.; Munoz, E.; Ang, M. C.; Diesta, C. C. E.; Go, C.; Sharma, N.; Bragg, D. C.; Talkowski, M. E.; MacDonald, M. E.; LEE, J.-M.; Ozelius, L. J.; Wheeler, V. C.

10.1101/2025.05.14.653432 — genetics — Posted on 2025-05-16

2791 Distinct Ca2+ signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammation

He, C.; Grubb, S.; Tao, L.; Kılıc, K.; Zhang, X.; Devor, A.; Sheikh, N. Z.; Cai, C.

10.1101/2025.05.13.653681 — neuroscience — Posted on 2025-05-16

2792 MAPK and mTORC1 signaling converge on Cyclin D to enable cell-cycle re-entry in melanoma persister cells

Nangia, V.; Ashraf, H.; Marikar, N.; Passanisi, V. J.; Ill, C. R.; Spencer, S. L.

10.1101/2025.05.14.653869 — systems biology — Posted on 2025-05-16

2793 Single-cell transcriptomic analyses unveil exercise-induced changes in murine skin vascular endothelial cells

Hejazi, P.; Mury, P.; Thorin, E.; Lettre, G.

10.1101/2025.05.13.653788 — physiology — Posted on 2025-05-16

2794 Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

Venkatasubramanian, R.; Darrah, M. A.; Mahoney, S. A.; Hutton, D. A.; Maurer, G. S.; Ludwig, K. R.; VanDongen, N. S.; Greenberg, N. T.; Longtine, A. G.; Brunt, V. E.; Singh, P.; Galligan, J. J.; Trujillo, M. N.; Kapahi, P.; Melov, S.; Campisi, J.; Rossman, M. J.; Seals, D. R.; Clayton, Z. S.

10.1101/2025.05.13.653823 — physiology — Posted on 2025-05-16

2795 Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity

Majcher, A.; Karsai, G.; Yusifov, E.; Schaettin, M.; Malagola, E.; Horvath, P.; Li, J.; Shamshiddinova, M.; Zhibo, G.; Dubey, R.; Peterson, T.; Rodriguez-Gallardo, S.; Kuniyoshi, S.; Harayama, T.; Hornemann, T.

10.1101/2025.05.13.653734 — biochemistry — Posted on 2025-05-16

2796 Oocyte mitochondria link maternal environment to offspring phenotype

Cooper, J.; Nguyen, K.; Gates, D.; Wolfrum, E.; Capan, C.; Lee, H.; Williams, D.; Okoye, C.; Nauta, K. M.; Sanchez-Avila, X.; Kelly, R. T.; Sheldon, R.; Wojtovich, A. P.; Burton, N. O.

10.1101/2025.05.13.653493 — genetics — Posted on 2025-05-16

2797 Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals

Etani, T.; Nakajima, S.; Honda, S.; Homma, S.; Kaneko, Y.; Kondoh, S.; Tarumi, R.; Tsugawa, S.; Moriyama, S.; Tobari, Y.; Samma, T.; Horga, G.; Cassidy, C.; Uchida, H.; Fujii, S.

10.1101/2025.05.10.653047 — neuroscience — Posted on 2025-05-16

2798 Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal

Stanton, C.; Choi, W.; Wiseman, L.; Bollong, M. J.

10.1101/2025.05.13.653579 — biochemistry — Posted on 2025-05-16

2799 Disregarding fish ageing method can compromise growth parameter comparability across studies

Pilipaityte, E.; Jakubaviciute, E.; Putys, Z.; Audzijonyte, A.

10.1101/2025.05.13.653728 — ecology — Posted on 2025-05-16

2800 Thermal suppression of gametogenesis can explain historical collapses in larval recruitment

Okamoto, D. K.; Spindel, N.; Munstermann, M. J.; Karelitz, S.; Collicutt, B.; Gimenez, I.; Rolheiser, K.; Cronmiller, E.; Foss, M.; Mahara, N.; Swezey, D.; Ferraro, R.; Rogers-Bennett, L.; Schroeter, S.

10.1101/2023.09.28.559919 — ecology — Posted on 2025-05-16

2801 Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception

Carricarte, T.; Xie, S.; Singer, J.; Trampel, R.; Huber, L.; Weiskopf, N.; Cichy, R. M.

10.1101/2025.05.13.653501 — neuroscience — Posted on 2025-05-16

2802 Alcohol use disorder is associated with increases in frontocentral phase-amplitude coupling strength during resting state

Richard, C. D.; Porjesz, B.; Meyers, J. L.; Bingly, A.; Chorlian, D. B.; Kamarajan, C.; Pandey, G.; Kuang, W.; Pandey, A. K.; Kinreich, S.

10.1101/2025.05.13.653768 — neuroscience — Posted on 2025-05-16

2803 Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional program of liver cells.

SOUAIFAN, H.; COSTALLAT, M.; SITKIEWICZ, L.; GODEST, K.; CAMMAS, F.; MANN, C.; MUCHARDT, C.; RACHEZ, C.

10.1101/2025.02.14.638307 — molecular biology — Posted on 2025-05-16

2804 Bidirectional modulation of reward-guided decision making by dopamine

Dias Maile, A. A.; Gruendler, T. O. J.; Fischer, A. G.; Froböse, M. I.; Kurtenbach, H.; Kaiser, L. F.; Jocham, G.

10.1101/2024.03.27.586793 — neuroscience — Posted on 2025-05-16

2805 Fornix subdivisions and spatial learning: a diffusion MRI study

Hodgetts, C. J.; Postans, M.; Williams, A. N.; Graham, K. S.; Lawrence, A. D.

10.1101/2025.05.15.654313 — neuroscience — Posted on 2025-05-16

2806 Rapid ethylene-triggered protein complex remodeling in dark grown hypocotyls

Lee, Y.; Park, H. L.; Yoon, G. M.; Szymanski, D. B.

10.1101/2025.05.15.654145 — plant biology — Posted on 2025-05-16

2807 Enteropancreatic neurons drive the glucoregulatory response to ingested lipid

Roberts, A. G.; Meyer, L.; Norton, M.; Phuah, P.; Martin Alonso, A.; Dowsett, G. K.; Cheng, S.; Dunsterville, C.; Liu, J.; Chung, P.-E.; Tao, Y.; Smitherman-Cairns, T.; Deutsch, A. B.; Chatterjee, A.; Lam, B. Y.; Hanyaloglu, A.; Jones, B.; Yeo, G. S. H.; Salem, V.; Murphy, K. G.

10.1101/2025.05.09.652620 — physiology — Posted on 2025-05-16

2808 Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium

Emin, M. T.; Dubuisson, A. M.; Sujin Kumar, P.; Knutsen, C.; Alvira, C. M.; Hough, R. F.

10.1101/2025.02.26.640349 — physiology — Posted on 2025-05-16

2809 Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer

Kay, J. E.; Corrigan, J. J.; Volk, L. B.; Armijo, A. L.; Nazari, I. S.; Torous, D. K.; Avlasevich, S. L.; Croy, R. G.; Wadduwage, D. N.; Dertinger, S. D.; Essigmann, J. M.; Samson, L. D.; Engelward, B. P.

10.1101/2025.05.13.653839 — cancer biology — Posted on 2025-05-16

2810 Oncogenic RAS signaling suppresses ferroptosis via transcriptional upregulation of GCH1

Lim, J. K.; Stoelting, F.; Levy, T.; Thewes, L.; Picard, D.; Tishina, S.; Zhang, H.-F.; Lewandowska, O.; Reiff, T.; Remke, M.; Braegelmann, J.; Beleggia, F.; Berndt, C.; von Karstedt, S.; Reifenberger, G.; Rotblat, B.; Leprivier, G.

10.1101/2024.01.27.577524 — cancer biology — Posted on 2025-05-16

2811 SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution

Liao, L.; Madan, E.; Palma, A.; Kim, H.; Kumar, A.; Bhoopathi, P.; Winn, R.; Trevino, J.; Fisher, P.; Brakebusch, C.; Kim, G.; Kim, J.; Gogna, R.; Won, K. J.

10.1101/2023.08.22.554277 — bioinformatics — Posted on 2025-05-16

2812 Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease

Busarello, E.; Biancon, G.; Cimignolo, I.; Lauria, F.; Ibnat, Z.; Ramirez, C.; Tome, G.; Ciuffreda, M.; Bucciarelli, G.; Pilli, A.; Marino, S. M.; Bontempi, V.; Ress, F.; Aass, K. R.; VanOudenhove, J. J.; Tiberi, L.; Mione, M.; Standal, T.; Macchi, P.; Viero, G.; Halene, S.; Tebaldi, T.

10.1101/2024.03.08.584053 — bioinformatics — Posted on 2025-05-16

2813 EnVhogDB: an extended view of the viral protein families on Earth through a vast collection of HMM profiles

Bucio, R. E. P.; Enault, F.; Galiez, C.

10.1101/2024.06.25.600602 — bioinformatics — Posted on 2025-05-16

2814 Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation

Seira Curto, J.; Fernandez Gallegos, M. R.; Villegas Hernandez, S.; Sanchez de Groot, N.

10.1101/2025.01.24.634659 — biochemistry — Posted on 2025-05-16

2815 Image-based DNA Sequencing Encoding for Detecting Low-Mosaicism Somatic Mobile Element Insertions

Tan, M.; Lin, Z.; Chen, Z.; Zhou, H.; Park, J.; He, Z.; Lee, E. A.; Gao, Z.; Zhu, X.

10.1101/2024.11.07.619809 — genomics — Posted on 2025-05-16

2816 Sex-biased gene expression under sexually antagonistic and sex-limited selection

Wiberg, R. A. W.; Zwoinska, M.; Kaufman, P.; Howie, J.; Immonen, E.

10.1101/2024.11.29.622017 — evolutionary biology — Posted on 2025-05-16

2817 Beyond urbanization metrics: Using graphical causal models to investigate mechanisms in urban ecology and evolution

Borden, J. B.; Gibbs, J.; Vanek, J. P.; Cosentino, B.

10.1101/2024.09.03.611045 — evolutionary biology — Posted on 2025-05-16

2818 Lightning-caused disturbance frequency and severity varies with topography in an Afromontane forest

Gora, E.; Ngute, A. S. K.; Batumike, R.; Cuni-Sanchez, A.; Imani, G.; Kaplin, B.; Bantlin, D.; Bitariho, R.; Zoletto, B.; Petridis, N.; Sheil, D.; Sullivan, M. J. P.

10.1101/2025.05.13.653675 — ecology — Posted on 2025-05-16

2819 eDNA sampling reveals no negative effects of beaver recolonisation on the catchment-scale distribution of migratory fish

Macarthur, J. A.; Law, A.; Willby, N.; Svobodova, D.; Griffiths, N. P.; Campbell, R.; Gaywood, M. J.; Bean, C. W.; Lawson Handley, L.; Smith, M.; Leonard, S.; Conroy, C.; Pritchard, V. L.; Hänfling, B.

10.1101/2025.05.13.653709 — ecology — Posted on 2025-05-16

2820 Non-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia Virus

Dalla Rosa, I.; Kent, L.; Way, M.

10.1101/2025.02.05.636656 — cell biology — Posted on 2025-05-16

2821 Oncogenic mutations disrupt lineage differentiation via epigenetic perturbations

Meng, L.; Yu, A.; Huang, H.; Meng, J.; Yoo, Y.; Schaukowitch, K. M.; Janas, J.; Knowles, D. A.

10.1101/2025.04.22.649974 — cell biology — Posted on 2025-05-16

2822 Neutralizing Activity of Cervicovaginal Secretions against Herpes Simplex Virus is Mediated by Mucosal IgG and Viral Glycoprotein E and Adversely Impacted by Vaginal Dysbiosis

MAHANT MAHANT, A.; Fong, V.; Gromisch, M.; Hunte, R.; Michael, I.; Aguilan, J. T.; Murphy, K.; Keller, M. J.; Herold, B.

10.1101/2025.05.15.654401 — microbiology — Posted on 2025-05-16

2823 PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity

Gonzalez Nunez, M.; C. Vasconcellos, L. R.; Garrido Mesa, J.; Cardoso Maciel Costa Silva, R.; Hachani, A.; Bosquet Agudo, A.; Simeoli, R.; Medrano Gonzalez, L.; Filloux, A.; C. E. Welch, H.; Perretti, M.; Vanhaesebroeck, B.; Dombrowicz, D.; Haworth, O.; Kok, K.; Manoury, B.; Aksoy, E.

10.1101/2025.05.13.653657 — immunology — Posted on 2025-05-16

2824 Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter

Ayyildiz, N.; Mueller, K.; Hardikar, S.; Beyer, F.; Enzenbach, C.; Baber, R.; Wirkner, K.; Zachariae, S.; Girbardt, J.; Hassett, J. D.; Anwander, A.; Elze, T.; Wang, M.; Witte, A. V.; Rauscher, F. G.; Villringer, A.

10.1101/2025.05.13.653685 — neuroscience — Posted on 2025-05-16

2825 Differential effects of ischemia and inflammation on plasma-derived extracellular vesicle characteristics and function

Couch, Y.

10.1101/2025.05.13.653696 — neuroscience — Posted on 2025-05-16

2826 Integrating explicit reliability for optimal choices: effect of trustworthiness on decisions and metadecisions

Ota, K.; Gajdos, T.; Ciston, A.; Haggard, P.; Charles, L.

10.1101/2025.01.12.632598 — neuroscience — Posted on 2025-05-16

2827 Homeostasis After Injury: How Intertwined Inference and Control Underpin Post-Injury Pain and Behaviour

Mahajan, P.; Dayan, P.; Seymour, B.

10.1101/2025.02.04.636410 — neuroscience — Posted on 2025-05-16

2828 Decoding hypnotic consciousness: neural and experiential insights into induced and ideomotor suggestions

Gelebart, J.; Foure, A.; Quentin, R.; Debarnot, U.

10.1101/2025.05.11.652707 — neuroscience — Posted on 2025-05-16

2829 EPIGENETIC REPROGRAMMING OF CELL IDENTITY IN THE RAT PRIMARY NEURON-GLIA CULTURES INVOLVES HISTONE SEROTONYLATION

Borodinova, A. A.; Leontovich, Y. A.; Beletskiy, A. P.; Revishchin, A. V.; Pavlova, G. V.; Balaban, P. M.

10.1101/2025.05.13.653697 — neuroscience — Posted on 2025-05-16

2830 Immediate TMS-EEG responses reveal motor cortex excitability

Stango, A.; Zazio, A.; Barchiesi, G.; Bonfiglio, N. S.; Dognini, E.; Marcantoni, E.; Bortoletto, M.

10.1101/2024.08.20.608770 — neuroscience — Posted on 2025-05-16

2831 Modeling the Co-Activation of Inflammatory Genes1Mediated by NFκB and IRF-3 During Viral Infections

Tiwari, S.; Basak, S.; Pandey, R.

10.1101/2025.05.13.653653 — systems biology — Posted on 2025-05-16

2832 Armadillo Repeat Only Proteins Are Required for the Function of Plant CNGC Channels.

Kulich, I.; Oulehlova, D.; Vladimirtsev, D.; Zou, M.; Lileikyte, E.; Kulichova, K.; Janda, M.; Iakovenko, O.; Neubergerova, M.; Studtrucker, T.; Pleskot, R.; Dietrich, P.; Fendrych, M.; Friml, J.

10.1101/2025.01.06.631460 — plant biology — Posted on 2025-05-16

2833 Unconventional myosin VI is involved in the regulation of muscle energy metabolism

Wojton, D.; Dymkowska, D.; Matysniak, D.; Topolewska, M.; Redowicz, M. J.; Lehka, L.

10.1101/2025.05.13.653637 — physiology — Posted on 2025-05-16

2834 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Zhang, X.; Li, Y.

10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-05-16

2835 Interactions of the Escherichia coli SMC-like RecN protein with different forms of DNA revealed at the single-molecule level using optical tweezers

Roshektaeva, V. D.; Alekseev, A. A.; Vedyaykin, A. D.; Khodorkovskii, M. A.; Morozova, N. E.

10.1101/2025.05.13.653842 — biophysics — Posted on 2025-05-16

2836 Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

Duran-Romana, R.; Schymkowitz, J.; Rousseau, F.; Louros, N. N.

10.1101/2025.05.14.653959 — biophysics — Posted on 2025-05-16

2837 Phase-Space Dynamics Reveal Structured and Chaotic Motility in Human Sperm via DTW Clustering

Sergounioti, A.; Alonaris, E.; Rigas, D.

10.1101/2025.05.13.653743 — biophysics — Posted on 2025-05-16

2838 Emergence of active contractile patterns alters monolayer force generation and transmission in response to focal adhesion distribution

Davis, J. R.; Solowiej-Wedderburn, J.; Vega, S. L.; Burdick, J. A.; Dunlop, C.; Tapon, N.

10.1101/2024.04.10.588783 — biophysics — Posted on 2025-05-16

2839 Tryptophan-aspartic acid containing peptide analog from coronin 1 inhibits model membrane fusion and enveloped viral infection in cells

Pandia, S.; Qazi, B.; Viswakarma, V.; Gautam, S.; Meshram, C. D.; Chakraborty, H.; Haldar, S.

10.1101/2025.05.14.653931 — biophysics — Posted on 2025-05-16

2840 Anionic Phospholipids Modulate Hepatitis C Virus Core Protein Assembly on Lipid Membranes

Mandal, T.; Albrecht, B.; Chiantia, S.

10.1101/2025.05.13.653720 — biophysics — Posted on 2025-05-16

2841 Divergent conformational mechanisms of JAK2V617F and TYK2V678F mutations in Thrombocythemia and related disorders: Molecular Dynamics insights into pathway activation and therapeutic targeting

Shao, T.; Gan, M.; Yin, Q.; Bai, J.; Yang, J.; Sun, S.

10.1101/2025.05.16.654435 — biophysics — Posted on 2025-05-16

2842 NuclePhaser: a YOLO-based framework for cell nuclei detection and counting in phase contrast images of arbitrary size with support of fast calibration and testing on specific use cases

Voloshin, N.; Putlyaev, E.; Chechekhina, E.; Usachev, V.; Karagyaur, M.; Bozov, K.; Grigorieva, O.; Tyurin-Kuzmin, P.; Kulebyakin, K.

10.1101/2025.05.13.653705 — bioinformatics — Posted on 2025-05-16

2843 Preprint: Triggered sequential viral-transduction from collagen-based scaffolds for tissue regeneration

Amante, J. J.; Twombly, B.; Thotathil, N.; Kearney, C. J.

10.1101/2025.05.13.653729 — bioengineering — Posted on 2025-05-16

2844 Monte Carlo track-structure simulation of the impact of Ultra-Hight Dose Rate and oxygen concentration on the Fenton reaction.

Chaoui, M.; Tayalati, Y.; Bouhali, O.; ramos mendez, j.

10.1101/2025.05.13.652705 — biochemistry — Posted on 2025-05-16

2845 Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism

cartmell, A.; Crawford, C. J.; Tomlinson, C. W.; Gunawan, C.; Chen, Z.; Byrne, D. P.; Darby, C.; Conti, M. L.; Larson, T.; Luis, A. S. J.; Elli, S.; Yates, E. A.; Bolam, D. N.; van der Post, S.; Williams, S. J.

10.1101/2024.04.27.591440 — biochemistry — Posted on 2025-05-16

2846 AI-Guided Discovery of LDHA Inhibitors Targeting Cancer Metabolism Using Machine Learning and Generative Chemistry: An End-to-End Drug Discovery Pipeline

Petalcorin, M. F.; Petalcorin, M. I. R.

10.1101/2025.05.13.653702 — biochemistry — Posted on 2025-05-16

2847 Multi-model reinforcement learning with online retrospective change-point detection

Chartouny, A.; Khamassi, M.; Girard, B.

10.1101/2025.05.13.653727 — animal behavior and cognition — Posted on 2025-05-16

2848 CHROMAS: A Computational Pipeline to Track Chromatophores and Analyze their Dynamics

Ukrow, J.; Renard, M. D. M.; Moghimi, M.; Laurent, G.

10.1101/2025.03.03.641160 — animal behavior and cognition — Posted on 2025-05-16

2849 ATaRVa: Analysis of Tandem Repeat Variation from Long Read Sequencing data

Sivakumar, A. K.; Sudarsanam, S.; Sharma, A.; Avvaru, A. K.; Sowpati, D. T.

10.1101/2025.05.13.653434 — genomics — Posted on 2025-05-16

2850 Natural diversity of telomere length distributions across 100 yeast strains

Garrido, C.; Kornobis, E.; Agier, N.; Ilioaia, O.; Fischer, G.; Xu, Z.

10.1101/2025.05.13.653712 — genomics — Posted on 2025-05-16

2851 Genomic changes are varied across congeneric species pairs of animals

Francis, W. R.; Vargas, S.; Woerheide, G.

10.1101/2024.09.05.611358 — genomics — Posted on 2025-05-16

2852 Systemic bio-inequity links poverty to biodiversity and induces a conservation paradox

Waldock, C.; Nguyen, V. T. H.; Awuor Owuor, M.; Samwel Manyanza, A.; Seehausen, O.

10.1101/2025.05.13.653456 — ecology — Posted on 2025-05-16

2853 From Red Tides to Healthy Ecosystems by NutrientManagement in Ise Bay and Mikawa Bay

Noda, I.; Iki, S.; Naruse, K.

10.1101/2025.05.13.653706 — ecology — Posted on 2025-05-16

2854 Landscape heterogeneity, forest structure and mammalian host diversity shape Ixodes ricinus density and Borrelia prevalence in German forests

Mueller, M.; Weilage, S.; Heyse, L. M. I.; Ruester, D.; Ayasse, M.; Pfeffer, M.; Obiegala, A.

10.1101/2025.05.13.653726 — ecology — Posted on 2025-05-16

2855 eDNA enables proof-of-origin of samples from reservoirs with rich and abundant biodiversity

REBELO, M. D. F.; CORTEZ, T.; Godinho, J. G. N.; Coelho, J.; Cavalcanti, R.; Bomfim, H.; Cunha, Y.; Dondero, F.; Amaral, D.; Americo, J. A.

10.1101/2025.05.13.653644 — ecology — Posted on 2025-05-16

2856 BirdNET can be as good as experts for acoustic bird monitoring in a European city

Fairbairn, A. J.; Burmeister, J.-S.; Weisser, W. W.; Meyer, S. T.

10.1101/2024.09.17.613451 — ecology — Posted on 2025-05-16

2857 Intensity Modulation of Trichromatic Split Fluorescent Proteins for Live Cell Mapping

Ishii, M.; Kinjo, T.; Kondo, Y.; Terai, K.; Aoki, K.; Kuhlman, B.; Matsuda, M.

10.1101/2025.05.13.653616 — cell biology — Posted on 2025-05-16

2858 Cellular metabolic state controls mitochondrial RNA kinetics

Reardon, S. D.; Bautista, C.; Cole, S. C.; Cicero, J.; Mishanina, T. V.

10.1101/2025.05.13.653903 — molecular biology — Posted on 2025-05-16

2859 A Short 63-Nucleotide Element Promotes Efficient circRNA Translation

Biagi, M. C.; Giuliani, A.; Grandioso, A.; Di Timoteo, G.; Bozzoni, I.

10.1101/2025.05.13.653105 — molecular biology — Posted on 2025-05-16

2860 A polycistronic locus encodes both a tumor-suppressive microRNA and a long non-coding RNA regulating testis morphology in Drosophila

Carney, T. D.; Shcherbata, H. R.

10.1101/2024.10.10.617551 — molecular biology — Posted on 2025-05-16

2861 Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

Kong, H.; Wu, X.; Yang, Q.; Sun, Q.; Yu, X.; Dai, Y.; Wu, C.; Xie, D.; Chen, L.; Ma, P.; Dai, S.; Chen, C.; Mi, P.; Feng, X.; Peng, Y.; Shi, H.; Zhang, D.; Ke, N.; Cao, D.; Zhou, Z.; Hu, B.; Wang, P.; Chen, L.; Liu, Y.-H.; Wei, Q.; Jiang, H.

10.1101/2024.07.24.604770 — immunology — Posted on 2025-05-16

2862 Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation

Dhariwala, M. O.; Carale, R. O.; DeRogatis, A. M.; Rodriguez-Valbuena, H.; Okoro, J. N.; Ekstrand, C.; Weckel, A. A.; Tran, V. M.; Habrylo, I.; Barrere-Cain, R.; Ojewumi, O. T.; Tammen, A. E.; Tsui, J.; Shaikh, S.; Yellamilli, S.; Aladhami, A. K.; Leech, J. M.; Merana, G. R.; Hiam-Galvez, K. J.; Halkias, J.; Gardner, J.; Rutishauser, R. L.; Fragiadakis, G. K.; Spitzer, M. H.; Combes, A. J.; Scharschmidt, T. C.

10.1101/2023.09.29.560039 — immunology — Posted on 2025-05-16

2863 Myeloid cell IL-15 production in the brain supports Bystander CD8+ T-Cell Neuropathic Immune Responses following Virus infection

Berger, J. N.; Rosales, A.; Heiden, D.; Monogue, B.; Beckham, J. D.; Berg, L. J.

10.1101/2025.05.13.653736 — immunology — Posted on 2025-05-16

2864 Robust TCR production for the structural study of TCR-pMHC complexes

Oyon-Olea, L.; Dichiara-Rodriguez, M. G.; Hervas-Stubbs, S.; Erausquin, E.; Lopez-Sagaseta, J.

10.1101/2025.05.12.653033 — immunology — Posted on 2025-05-16

2865 Individual Differences in Policy Precision: Links to Suicidal Ideation and Network Dynamics

Yoon, D.; Kim, J.; Kim, D. H.; Shin, D. W.; Bong, S. H.; Kim, J.; Park, H.-j.; Jeon, H. J.; Jeong, B.

10.1101/2024.10.15.618415 — neuroscience — Posted on 2025-05-16

2866 NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia Telangiectasia

Stirparo, G. G.; Xu, X.; Thompson, T.; Page, K.; Harvey, J. R.; Cadwalladr, D.; Lawrence, J.; Burley, R. J.; Juvvanapudi, J.; Roberts, M.; Barker, D. F.; Mulligan, V.; Sherlock, C.; Lizio, M.; Christie, L.; Mudaliar, M.; Sheardown, S.; Margus, B.; Thompson, C.; Dickson, L.; Brice, N. L.; Carlton, M. B.; Powell, J. A.; Dawson, L. A.

10.1101/2025.05.13.653662 — neuroscience — Posted on 2025-05-16

2867 High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease

Saito, K.; Goulding, D. S.; Nolt, G. L.; Dimas, S. H.; Moore, L. C.; Stevens, I. O.; Anderson, S.; Snipes, A.; Macauley, S. L.; Nelson, P. T.; Johnson, L.; Morganti, J.

10.1101/2025.05.16.654329 — neuroscience — Posted on 2025-05-16

2868 Humans adapt rationally to approximate estimates of uncertainty

Pulcu, E.; Browning, M.

10.1101/2023.11.26.568699 — neuroscience — Posted on 2025-05-16

2869 A model of Rtc-regulated RNA repair reveals heterogeneous responses to ribosome-targeting antibiotics and suggests molecular targets to potentiate their effects

Hindley, H. J.; Kotta-Loizou, I.; Moradian, S.; Giuliano, M. G.; Buck, M.; Engl, C.; Weisse, A. Y.

10.1101/2024.05.20.594959 — systems biology — Posted on 2025-05-16

2870 Fine-tuning quantitative agronomic traits by manipulating gene copy number in rice

Nomura, C.; Kanzaki, H.; Kanzaki, E.; Shimizu, M.; Oikawa, K.; Utsushi, H.; Ito, K.; Sugimura, Y.; Terauchi, R.; Abe, A.

10.1101/2025.05.16.654416 — plant biology — Posted on 2025-05-16

2871 Arabidopsis lines with modified ascorbate concentrations reveal a link between ascorbate and auxin biosynthesis

Fenech, M.; Zulian, V.; Moya-Cuevas, J.; Arnaud, D.; Morilla, I.; Smirnoff, N.; Botella, M. A.; Stepanova, A. N.; Alonso, J. M.; Martin-Pizarro, C.; Amorim-Silva, V.

10.1101/2025.05.15.654287 — plant biology — Posted on 2025-05-16

2872 Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in Non-Small cell Lung Cancer patients undergoing anti-PD1 therapy

Jain, K.; Goel, A.; Mehra, D.; Rathore, D. K.; Binayke, A.; Aggarwal, S.; Ganguly, S.; Awasthi, A.; MADAN, E.; Ganguly, N. K.

10.1101/2025.05.13.653410 — cancer biology — Posted on 2025-05-16

2873 Scalable Inference and Identifiability of Kinetic Parameters for Transcriptional Bursting from Single Cell Data

Gu, J.; Laszik, N.; Miles, C. E.; Downing, T. L.; Allard, J.; Read, E. L.

10.1101/2025.05.13.653671 — biophysics — Posted on 2025-05-16

2874 Variational inference of single cell time series

Xu, B.; Braun, R.

10.1101/2024.08.29.610389 — bioinformatics — Posted on 2025-05-16

2875 A Molecular Dynamics Protocol for Rapid Prediction of EGFR Overactivation and Its Application to the Rare Mutations S768I, S768N, D761N

Behn, J.; Deepak, R. N. V. K.; Hu, J.; Fan, H.

10.1101/2025.02.27.640703 — bioinformatics — Posted on 2025-05-16

2876 TEA-GCN: Constructing Accurate, Species-comparable, and Explainable Gene Regulatory and Functional Networks via Condition-Specific Ensemble Co-expression

Lim, P. K.; Wang, R.; Lim, S. C.; Antony Velankanni, J. P.; Mutwil, M.

10.1101/2024.07.22.604713 — bioinformatics — Posted on 2025-05-16

2877 Megabase-scale human genome rearrangement with programmable bridge recombinases

Perry, N. T.; Bartie, L. J.; Katrekar, D.; Gonzalez, G. A.; Durrant, M. G.; Pai, J. J.; Fanton, A.; Hiraizumi, M.; Ricci-Tam, C.; Nishimasu, H.; Konermann, S.; Hsu, P. D.

10.1101/2025.05.14.653916 — bioengineering — Posted on 2025-05-16

2878 ERGA-BGE genome of Pinctada radiata (Leach, 1814): one of the first Lessepsian migrants

Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Genoscope Sequencing Team, ; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Istace, B.; Couloux, A.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Haggerty, L.; Martin, F.; Bortoluzzi, C.

10.1101/2025.01.17.632165 — genomics — Posted on 2025-05-16

2879 Constrained Open Chromatin Regions Reveal Functional Elements Shaping Human Traits

Tomizuka, K.; Koido, M.; Suzuki, A.; Yoshino, S.; Tanaka, N.; Ishikawa, Y.; Liu, X.; Koyama, S.; Ishigaki, K.; Murakawa, Y.; Immune transcript/enhancer consortium (ITEC), ; Yamamoto, K.; Terao, C.

10.1101/2024.10.31.621195 — genetics — Posted on 2025-05-16

2880 Loss of dihydroceramide desaturase drives neurodegeneration by disrupting endoplasmic reticulum and lipid droplet homeostasis in glial cells

Zhu, Y.; Cho, K.; Lacin, H.; Zhu, Y.; DiPaola, J. T.; Wilson, B. A.; Patti, G. J.; Skeath, J. B.

10.1101/2024.01.01.573836 — developmental biology — Posted on 2025-05-16

2881 Epigenomic dynamics of clonal evolution reveal new regulators of leukemic growth

Bonilla, G.; Morris, A.; Kundu, S.; Ducasse, A.; Kirkpatrick, G.; Jeffries, N. E.; Chetal, K.; Yvanovich, E. E.; Milosevic, J.; Zhao, T.; Xia, J.; Barghout, R.; Scadden, D.; Mansour, M.; Kingston, R. E.; Sykes, D. B.; Mercier, F. E.; Sadreyev, R. I.

10.1101/2024.02.29.582846 — molecular biology — Posted on 2025-05-16

2882 Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy

Ribis, J. W.; Nieto-Acuna, C. A.; DiBenedetto, N.; Mehra, A.; Dong, Q.; Nagawa, I. L.; El Meouche, I.; Aldridge, B. B.; Dunlop, M. J.; Tamayo, R.; Singh, A.; Shen, A.

10.1101/2024.02.13.580212 — microbiology — Posted on 2025-05-16

2883 Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

Seo, J.; Kim, S. H.; Lee, J.; Kim, M. S.; Lee, Y.-S.; Kim, S. J.

10.1101/2024.01.06.574489 — neuroscience — Posted on 2025-05-16

2884 Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab

Kyyriainen, J.; Della Pietra, A.; Torkamani-Azar, M.; Gomez- Budia, M.; Novosolova, N.; Eronen, H.; Narvaez, O.; Paasonen, E.; Lezhneva, V.; Pelkonen, A.; Saveleva, L.; Huotarinen, A.; Belevich, I.; Jokitalo, E.; Kuopio Epilepsy Center Epilepsy Surgery Group, ; Jutila, L.; Rauramaa, T.; Immonen, A.; Leinonen, V.; Tohka, J.; Grohn, O.; Kalviainen, R.; Malm, T.; Sierra, A.

10.1101/2025.04.15.648977 — neuroscience — Posted on 2025-05-16

2885 Condenzymes: Biomolecular condensates with inherent catalytic activities

Chen, M. W.; Guo, X.; Farag, M.; Qian, N.; Song, X.; Ni, A.; Liu, V.; Yu, X.; Ma, Y.; Yang, L.; Yu, W.; King, M.; Lee, J.; Zare, R. N.; Min, W.; Pappu, R. V.; Dai, Y.

10.1101/2024.07.06.602359 — biophysics — Posted on 2025-05-16

2886 Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22

Yamaguchi, T.; Okatsu, K.; Kubota, M.; Mitsumori, A.; Yamagata, A.; Fukata, Y.; Fukata, M.; Shibata, M.; Fukai, S.

10.1101/2025.01.06.631603 — biochemistry — Posted on 2025-05-16

2887 Specificity profiling of SARS-CoV-2 PLpro using proteome-derived libraries of linear peptides suggests secondary preference for basic motifs

Vogele, D.; Froehlich, K.; Bolgi, O.; Peters, C.; Geiss-Friedlander, R.; Schilling, O.

10.1101/2025.05.15.654199 — biochemistry — Posted on 2025-05-16

2888 Human receptive endometrial assembloid for deciphering the implantation window

Zhang, Y.; Zhao, R.; Yang, C.; Song, J.; Liu, P.; Li, Y.; Liu, B.; Li, T.; Yin, C.; Lu, M.; Hou, Z.; Zhang, C.; Chen, Z.-J.; Wu, K.; Zhao, H.

10.1101/2023.07.27.550771 — cell biology — Posted on 2025-05-16

2889 The roles of space and food web complexity in mediating ecological recovery

Gawecka, K. A.; Barbour, M. A.; Bullock, J. M.; Bascompte, J.

10.1101/2025.05.13.653715 — ecology — Posted on 2025-05-16

2890 Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

McCubbin, R. A.; Auwal, M. A.; Wang, S.; Zepeda, S. A.; Sasik, R.; Zeller, R. W.; Ross, K. G.; Zayas, R. M.

10.1101/2025.05.15.654132 — developmental biology — Posted on 2025-05-16

2891 The planktonic microbiome of the Great Barrier Reef

Robbins, S. J.; Dougan, K.; Terzin, M.; Zaugg, J.; Bell, S. C.; Laffy, P. W.; Engelberts, J. P.; Webster, N. S.; Hugenholtz, P.; Bourne, D. G.; Yeoh, Y. K.

10.1101/2025.05.13.653689 — genomics — Posted on 2025-05-16

2892 A BRCT Domain-Containing Protein Induced in Early Phagocytosis Plays a Crucial Role in Mucorales Pathogenesis

Tahiri, G.; Lax, C.; Binder, U.; Scheler, J.; Navarro, E.; Nicolas, F. E.; Garre, V.

10.1101/2025.05.13.652844 — genetics — Posted on 2025-05-16

2893 Polycomb repressive complex 2 regulates sexual development in Neurospora crassa

Deaven, A. M.; Ameri-Solanky, A. J.; Lewis, Z. A.

10.1101/2025.05.15.654408 — genetics — Posted on 2025-05-16

2894 Comprehensive Functional Self-Antigen Screening to Assess Cross-Reactivity in a Promiscuous Engineered T-cell Receptor

Sharma, G.; Teng, F.; Round, J.; Sneddon, S.; Brown, S.; Sivasothy, S.; Holt, R.

10.1101/2025.05.13.653646 — immunology — Posted on 2025-05-16

2895 Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

Aprile, D.; Leonardi, O.; Petrella, A.; Castaldi, D.; Culotta, L.; Cheroni, C.; Valente, A.; Bonfanti, M.; Vitriolo, A.; Moriano, J.; Mirabella, F.; Tintori, A.; Boeckx, C.; Testa, G.

10.1101/2025.05.14.653684 — neuroscience — Posted on 2025-05-16

2896 Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties

Tang, N.; Wilson, K.; Weldemarian, M. M.; Tian, H.; Hart, C. D.; Rammath, P.; Sivalingam, D. S.; Glazier, J.; Jiang, J.; Leong, N.; Lowe, T.; Kane, M. A.; Iwamoto, M.; Kuo, C. K.; Enomoto-Iwamoto, M.

10.1101/2025.05.13.653102 — pathology — Posted on 2025-05-16

2897 PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

Wang, H.; Yun, Z.; Cao, Y.; Li, X.; Liu, Z.; Pai, C.-P.; Wu, C.; Yue, J.; Lin, G.; Cai, J.; Willard, B.; Yang, S.; Keri, R. A.; Schiemann, W. P.; Diehl, J. A.; Kao, H.-Y.

10.1101/2025.05.15.653365 — cancer biology — Posted on 2025-05-16

2898 Single-Cell RNA Sequencing and Inferred Protein Activity Analysis Reveal a Distinct Tumor Phenotype in Early-Onset Colorectal Cancer Patients

Cohen, D. A.; Obradovic, A.; Jovanovic, L.; Mitani, Y.; Li, T.; Lee, S.; De, D.; Bethancourt, C.-N.; Shin, A.; Dunbar, K.; Cambuli, F.; Lengner, C.; Li, N.; Rogers, C.; Ho, J.; Jakubikova, V.; Blystone, E.; Pumpalova, Y.; Dionigi, B.; Vickovic, S.; Cheng, C.-W.; Gabre, J.

10.1101/2025.05.15.653154 — cancer biology — Posted on 2025-05-16

2899 Sampling and ranking of protein conformations using machine learning techniques do not improve quality of rigid protein-protein docking

Kyrylenko, R.; Koleiev, I.; Savchenko, I.; Voitsitskyi, T.; Stratiichuk, R.; Husak, V.; Yesylevskyy, S.; Starosyla, S.; Nafiiev, A.

10.1101/2025.05.13.652389 — biophysics — Posted on 2025-05-16

2900 Chip-Based 3D Interferometric Nanoscopy

Wang, W.; Li, H.; Wang, Y.; Barnett, S. F. H.; Huang, Z.; Kanchanawong, P.

10.1101/2025.05.13.653677 — biophysics — Posted on 2025-05-16

2901 ECCFP: a consecutive full pass based bioinformatic analysis for eccDNA identification using Nanopore sequencing data

Zhang, T.; Li, W.; Zeng, Q.; Zhang, J.; Miao, B.; Li, M.; Luo, J.; Liu, T.; Chen, S.; Wan, S.

10.1101/2025.05.13.653627 — bioinformatics — Posted on 2025-05-16

2902 RP3Net: a deep learning model for predicting recombinant protein production in Escherichia coli

Tankhilevich, E.; Martinez Cuesta, S.; Barett, I.; Berg, C.; Holmberg Schiavone, L.; Leach, A. R.

10.1101/2025.05.13.652824 — bioinformatics — Posted on 2025-05-16

2903 Gene co-expression networks highlight key nodes associated with Ammonium nitrate in sugarcane

Munoz-Perez, J. M.; Bassi, D.; Mattiello, L.; Menossi, M.; Riano-Pachon, D. M.

10.1101/2025.05.14.652917 — bioinformatics — Posted on 2025-05-16

2904 SKiM: Accurately Classifying Metagenomic ONT Reads in Limited Memory

Schneggenburger, T.; Zola, J.

10.1101/2025.05.13.653326 — bioinformatics — Posted on 2025-05-16

2905 Discovering dispersion: How robust is automated model discovery for human myocardial tissue?

Martonova, D.; Leyendecker, S.; Holzapfel, G. A.; Kuhl, E.

10.1101/2025.05.15.651144 — bioengineering — Posted on 2025-05-16

2906 Mechanistic crop modelling and AI for ideotype optimization: Crop-scale advances to enhance yield and water use efficiency

Correa, E. S.

10.1101/2025.05.15.652350 — bioengineering — Posted on 2025-05-16

2907 Sequential Amino Acid Mutagenesis-Driven De Novo Evolution of Adenine Deaminases Enables Efficient In Vivo Base Editing in Primate

Liao, J.; Zhang, H.; Chen, S.; Hsiao, S.; Lai, C.; Feng, H.; Ren, W.; Feng, C.; Xie, D.; Zheng, Y.; Cai, W.; Wang, W.; Jiang, Y.; Wang, D.; Zuo, E.; Wang, Z. J.; Lu, Y.; Wu, Y.

10.1101/2025.05.14.653640 — bioengineering — Posted on 2025-05-16

2908 Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface

Hulleman, J.; Jeon, S.; Bali, S.; DiCesare, S.; Abbas, A.; Daniel, S.; Ortega, A.; Collier, G.; Yang, J.; Bhattacharyaa, A.; McCoy, M.; Joachimiak, L. A.; Posner, B.

10.1101/2025.05.13.651909 — biochemistry — Posted on 2025-05-16

2909 Chromosome-level genome assembly of Norwegian wild alpine reindeer (Rangifer tarandus tarandus)

Torresen, O. K.; Tooming-Klunderud, A.; Skage, M.; Streitlien, A. E.; Strand, O.; Rolandsen, C.; Ferrari, G.; Cerca, J.; Mysterud, A.; Jakobsen, K. S.

10.1101/2025.05.15.652595 — genomics — Posted on 2025-05-16

2910 Empowering medaka fish biology with versatile genomic resources in MedakaBase

Morikami, K.; Tanizawa, Y.; Yagura, M.; Sakamoto, M.; Kawamoto, S.; Nakamura, Y.; Yamaguchi, K.; Shigenobu, S.; Naruse, K.; Ansai, S.; Kuraku, S.

10.1101/2025.05.13.653297 — genomics — Posted on 2025-05-16

2911 An ATP-binding cassette subfamily C is crucial for flavonoid sequestration in the domestic silkworm, Bombyx mori

Waizumi, R.; Hirayama, C.; Watanabe, K.; Iizuka, T.; Takasu, Y.; Sezutsu, H.

10.1101/2025.05.14.652641 — genetics — Posted on 2025-05-16

2912 Loss of the cytosolic DNA-sensing genes cGAS and STING1 inarmadillos (Cingulata)

Schaffer, L.; Ivanhoff, A. N.; Delsuc, F.; Lynch, V. J.

10.1101/2025.05.13.651073 — evolutionary biology — Posted on 2025-05-16

2913 Emergent higher-order interactions enable coexistence in phage-bacteria community dynamics

Dey, R.; Coenen, A. R.; Solonenko, N. E.; Burris, M. N.; Mackey, A. I.; Galasso, J.; Sun, C. L.; Demory, D.; Muratore, D.; Beckett, S. J.; Sullivan, M. B.; Weitz, J. S.

10.1101/2025.05.15.651590 — ecology — Posted on 2025-05-16

2914 Honeybees collect pollen from the buzz-pollinated flowers of invasive Solanum elaeagnifolium in Northern Greece

Kantsa, A.; Kariyat, R. R.; Lambert, H.; Nakas, G.; Petanidou, T.; De Moraes, C. M.; Mescher, M. C.

10.1101/2025.05.13.648936 — ecology — Posted on 2025-05-16

2915 Spring ephemeral Erythronium umbilicatum may not be vulnerable to phenological mismatch with overstory trees

Schopler, M.; Simha, A.; Dalton, R. M.; Wilson, E. M.; Redick, E.; Youngsteadt, E.; Petry, W. K.

10.1101/2025.05.14.652260 — ecology — Posted on 2025-05-16

2916 Genetic ablation of Pth4 disrupts calcium-phosphate balance, bone development, and kidney transcriptome in teleosts

Mendez-Martinez, L.; Suarez-Bregua, P.; Guerrero-Pena, L.; Costas-Prado, C.; Barreiro-Docio, E.; Cobelo-Garcia, A.; Rotllant, J.

10.1101/2025.05.13.653078 — developmental biology — Posted on 2025-05-16

2917 The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells

Sanchez, K. R.; Burgess, J. G.; Zheng, Q.; Alam, U.; Neiland, H.; Berwick, R.; Andersson, D.; Korver, S.; Marshall, A.; Goebel, A.; Dong, X.

10.1101/2025.05.15.652596 — immunology — Posted on 2025-05-16

2918 Large-Scale Genomic Analysis of CpG-Mediated Immunogenicity in Bacteriophages and a Novel Predictive Risk Index

Kharrat, L.; Garcia-Botero, C. A.; Ingersoll, W.; Luong, T.; Reyes, A.; Roach, D. R.

10.1101/2025.05.15.652987 — immunology — Posted on 2025-05-16

2919 Inhibition of IL2Rβ-dependent STAT5 activity supports T-cell stemness and augments antitumor efficacy of CD8+ T cells by preventing T-cell exhaustion

Shourian, M.; Bourdin, B.; El-Hachem, N.; Ruisseaux, C.; Vallee, A.; Romero, H.; Kwarteng, E. O.; Haddad, E.; Lavallee, V.-P.; Beltra, J.-C.; Decaluwe, H.

10.1101/2025.05.14.651875 — immunology — Posted on 2025-05-16

2920 Universal Dual-Target CAR-γδT Cells Targeting B7-H3 and IL13Rα2 for Glioblastoma Therapy

Xu, Y.; Ye, Y.; Wang, Y.; Liu, G.

10.1101/2025.05.14.653035 — immunology — Posted on 2025-05-16

2921 Monte Carlo track-structure simulation of the impact of Ultra-Hight Dose Rate and oxygen concentration on the Fenton reaction.

Chaoui, M.; Tayalati, Y.; Bouhali, O.; ramos mendez, j.

10.1101/2025.05.13.652705 — biochemistry — Posted on 2025-05-16

2922 Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

Black, A. M.; Komatsu, N.; Zhao, J.; Taskey, S. R.; Serrano, N. S.; Sharma, R.; Manoli, D. S.; Landry, M. P.; Beery, A.

10.1101/2025.05.15.654128 — animal behavior and cognition — Posted on 2025-05-16

2923 Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

Binagui-Casas, A.; Granes, A.; Ceccarelli, A.; Karagianni, E.; Ramajo, D. L.; Portero, R.; Annoh, J.; French, M.; Wong, F. C. K.; Chara, O.; Lowell, S.; Wilson, V.

10.1101/2025.05.15.654369 — developmental biology — Posted on 2025-05-15

2924 A lateral tension model for cranial mouse neural tube closure

De La O, J.; Galea, G. L.; Martin, A.

10.1101/2025.05.15.654327 — developmental biology — Posted on 2025-05-15

2925 RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection

Lari, A.; Shah, S. B.; Mao, X.; Sanghrajka, P.; Karijolich, J.; Lareau, L. F.; Glaunsinger, B. A.

10.1101/2025.05.14.654096 — molecular biology — Posted on 2025-05-16

2926 The Ataxin-2 protein is required in Kenyon cells for RNP-granule assembly and appetitive long-term memory formation.

Roselli, C.; Hillebrand, J.; Kaldun, J.; Monteiro, V.; Hurd, T.; Sprecher, S. G.; Boto, T.; Ramaswami, M.

10.1101/2025.05.15.654326 — neuroscience — Posted on 2025-05-15

2927 Hierarchical recurrent temporal prediction as a model of the mammalian dorsal visual pathway

Klavinskis-Whiting, S.; King, A. J.; Harper, N. S.

10.1101/2025.05.15.654214 — neuroscience — Posted on 2025-05-15

2928 Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder

Rashid, H. A.; Kircher, T.; Straube, B.

10.1101/2025.05.15.653451 — neuroscience — Posted on 2025-05-15

2929 Fornix subdivisions and spatial learning: a diffusion MRI study

Hodgetts, C. J.; Postans, M.; Williams, A. N.; Graham, K. S.; Lawrence, A. J.

10.1101/2025.05.15.654313 — neuroscience — Posted on 2025-05-16

2930 Contextual High-throughput 3D Volume Electron Microscopy Data Acquisition Using Artificial Intelligence

Konecna, T. H.; Jancik, R.; Slamkova, D.; Pribyl, B.; Tomova, C.; Rotkina, L.; Burch-Smith, T.; Sviben, S.; Fitzpatrick, J. A. J.; Czymmek, K. J.

10.1101/2025.05.15.654255 — cell biology — Posted on 2025-05-15

2931 Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Rochussen, A. M.; Kebabci, A. O.; Winkel, A. K.; Franze, K.; Fletcher, D. A.; Griffiths, G. M.; Lippert, A. H.

10.1101/2025.05.15.654337 — cell biology — Posted on 2025-05-15

2932 Regulation of Epithelial HIF by Probiotic Escherichia coli

Dowdell, A. S.; Roer, R. L.; Bhagavatula, G.; Cartwright, I. M.; Cohen, R. H.; Countess, J. A.; Koch, S. D.; Lee, J. S.; Steiner, C. A.; Thompson, N. T.; Villamaria, Z. F.; Welch, N. M.; Worledge, C. S.; Zhou, L.; Colgan, S. P.

10.1101/2025.05.14.654147 — cell biology — Posted on 2025-05-15

2933 A Conserved Disruption of the Nuclear Permeability Barrier in Meiosis is Controlled by a Kinase-Phosphatase Pair in Saccharomyces cerevisiae

Walsh, M. E.; Chetlapalli, K.; Upadhyayula, S.; King, G. A.; Ünal, E.

10.1101/2025.05.14.654091 — cell biology — Posted on 2025-05-15

2934 IntAct-U-ExM: Ultrastructure Expansion microscopy of actin networks via an internally-tagged actin

Dhar, A.; Palani Balaji, N. K.; Mullick, S.; Dey, S.; Ghosh, A.; Nair, D. K.; Gadadhar, S.; Palani, S.

10.1101/2025.05.14.654030 — cell biology — Posted on 2025-05-15

2935 Macrophages migrate persistently and directionally upon entering 2D confinement in the presence of extracellular matrix

Stinson, M. W.; Paulson, S. G.; Carlile, E. M.; Rotty, J. D.

10.1101/2025.05.15.654321 — cell biology — Posted on 2025-05-15

2936 Prg4+ fibro-adipogenic progenitors in muscle are crucial for bone fracture repair

He, Q.; Lu, J.; Liang, Q.; Yao, L.; Sun, T.; Wang, H.; Duffy, M.; Jiang, X.; Lin, Y.; Lee, J.-H.; Ahn, J.; Dyment, N.; Mourkioti, F.; Boerckel, J. D.; Qin, L.

10.1101/2025.05.14.654160 — cell biology — Posted on 2025-05-15

2937 Control of myogenesis by the E3 ubiquitin ligase CUL3-BTBD9

Padovani, C.; Perez, F. R.; Tsai, M.; Xiong, J.; Pogson, A.; Martinez, B.; Rape, M.

10.1101/2025.05.15.654347 — cell biology — Posted on 2025-05-15

2938 Chromatin Protection by the Chromosomal Passenger Complex

Gireesh, A.; Abad Fernandez, M.-A.; Nozawa, R.-S.; Sotelo-Parrilla, P.; Dury, L. C.; Likhodeeva, M.; Spanos, C.; Peralta, C. C.; Rappsilber, J.; Hopfner, K.-P.; Wilson, M. D.; Vanderlinden, W. D.; Hirota, T.; Jeyaprakash, A. A.

10.1101/2025.05.15.654082 — biochemistry — Posted on 2025-05-15

2939 Mycobacterial EtfD contains an unusual linear cluster and enables β-oxidation to drive proton pumping by the electron transport chain

Courbon, G. M.; Makarov, V.; Cole, S. T.; Schnappinger, D.; Ehrt, S.; Rubinstein, J. L.

10.1101/2025.05.14.654035 — biochemistry — Posted on 2025-05-15

2940 A Protein Disulfide Isomerase Coordinates Redox Homeostasis and ER Calcium Regulation for Optimal Lytic Cycle Progression in Toxoplasma gondii

Moen, K. E.; Moreno, S. N. J.

10.1101/2025.05.15.654346 — cell biology — Posted on 2025-05-15

2941 Mycobacterium tuberculosis-infected macrophages accumulate more nanoparticles

Pochet, A.; Bourguignon, T.; Grande, A.; Alfredo Godinez-Leon, J.; Fine, J.; Brodin, P.; Machelart, A.; Gref, R.

10.1101/2025.05.15.654063 — cell biology — Posted on 2025-05-15

2942 Circular RNA profiling revealed an evolutionarily conserved circACACA promotes liver lipid metabolism, oxidative stress, and autophagy disorder in a ceRNA manner

Zhao, J.; Han, S.; Xiang, J.; Chen, Y.; Zhao, X.; Wang, W.; Zhang, Y.; Zhu, Q.; Liu, C.; Yin, H.

10.1101/2025.05.15.654219 — cell biology — Posted on 2025-05-15

2943 Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses

Travers, J.; Huang, E.; McMullen, M. R.; Wu, J.; Cajigas-Du Ross, C. K.; Paouri, E.; Davalos, D.; Pathak, V.; Rotroff, D. M.; Nagy, L. E.

10.1101/2025.05.14.654103 — cell biology — Posted on 2025-05-15

2944 Evaluating the antiviral activity of Termin-8 and Finio against a surrogate ASFV-like algal virus

Palowski, A.; Domingues, F.; Lopez, O.; Holcombe, N.; Shurson, G.; Schroeder, D.

10.1101/2025.05.14.654024 — molecular biology — Posted on 2025-05-15

2945 The Environment-Dependent Regulatory Landscape of the E. coli Genome

Roeschinger, T.; Lee, H. J.; Pan, R. W.; Solini, G.; Faizi, K.; Quan, B.; Chou, T. F.; Mani, M.; Quake, S.; Phillips, R.

10.1101/2025.05.13.653802 — molecular biology — Posted on 2025-05-15

2946 Beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual postural task

Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Szul, M. J.; Bonaiuto, J. J.; Bonnefond, M.; Schmitz, C.

10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-05-15

2947 Identification and characterization of a small-molecule inhibitor of the Pseudomonas aeruginosa SOS response

Vascon, F.; Fongaro, B.; Mickevicius, V.; Pasquato, A.; Grybaite, B.; Petraitis, V.; Polverino de Laureto, P.; Tondi, D.; Kavaliauskas, P.; Cendron, L.

10.1101/2025.05.13.651886 — biochemistry — Posted on 2025-05-15

2948 ZNF638 represses the transcription of HBV closed circular DNA involving HUSH complex-mediated histone modifications of epigenetic silencing

Meng, S.; Sha, X.; Zhang, G.; Duan, B.; Wang, J.; Si, Y.; Li, F.; Wu, Q.; Cheng, S.; Ding, W.

10.1101/2025.05.15.654218 — biochemistry — Posted on 2025-05-15

2949 The Iron Metalloproteome of Pseudomonas aeruginosa Under Oxic and Anoxic Conditions

Saito, M.; McIlvin, M. R.

10.1101/2025.01.15.633287 — biochemistry — Posted on 2025-05-15

2950 Structural Basis of Herpesvirus Helicase-Primase Inhibition by Pritelivir and Amenamevir

Baranovskiy, A. G.; He, Q.; Suwa, Y.; Morstadt, L. M.; Babayeva, N. D.; Lim, C. J.; Tahirov, T. H.

10.1101/2025.05.15.654119 — biochemistry — Posted on 2025-05-15

2951 Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions

Unnikrishnan, A.; Chung, D. h.; Connelly, E. J.; Chuo, S.-W.; Devi, S.; Thwin, A. C.; Nadel, C. M.; Tse, E.; Gestwicki, J. E.; Craik, C. S.; Southworth, D. R.

10.1101/2025.05.15.654159 — biochemistry — Posted on 2025-05-15

2952 Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity

Milovanovic, D.; Duc, J.; Matsushima, W.; Hamelin, R.; Planet, E.; Offner, S.; Rosspopoff, O.; Trono, D.

10.1101/2025.05.13.653700 — genomics — Posted on 2025-05-15

2953 Identification of a sex-determining locus potentially involved in a conflict over sex-ratio

Lheraud, B.; Dussert, Y.; Chebbi, M. A.; Giraud, I.; Cordaux, R.; Peccoud, J.

10.1101/2025.05.14.654164 — genomics — Posted on 2025-05-15

2954 Non-redundant roles of the HDAC3 corepressor complex subunits SMRT and NCOR in controlling inflammatory and metabolic macrophage pathways

Efthymiadou, A.; Gu, C.; Wang, C.; Wang, H.; Li, Z.; Garcia-Irigoyen, O.; Fan, R.; Treuter, E.; Huang, Z.

10.1101/2025.05.13.653058 — molecular biology — Posted on 2025-05-15

2955 Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems

Garcia-Rodriguez, F.-J.; Valenzuela, C.; Bernal-Bayard, J.; Escoll, P.

10.1101/2025.05.15.653970 — microbiology — Posted on 2025-05-15

2956 A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication

Rajasekharan, S.; Barragan Torres, V. A.; Cortes Pinheiro Gomes, Y.; Wilken, L.; Overhoff, K.; Lin, Y.-C.; Patten, S. A.; Watanabe, S.; Chatel-Chaix, L.; Scaturro, P.

10.1101/2025.05.15.653649 — microbiology — Posted on 2025-05-15

2957 Defining the role of Pseudomonas aeruginosa PilY1 in signaling and virulence

Pritchett, C. L.; Damron, F. H.; Barbier, M.

10.1101/2025.05.15.654335 — microbiology — Posted on 2025-05-15

2958 Estrous cycle stage gates the effect of stress on reward learning

Johnston, M. P.; Garcia-Castaneda, B. I.; Cedillo, L. G.; Patel, S. K.; Vargas, V. S.; Wanat, M. J.

10.1101/2025.03.23.644830 — neuroscience — Posted on 2025-05-15

2959 Improved flux profiling in genome-scale modeling of human cell metabolism

Huijer, C.; Jiao, X.; Chen, Y.; Yu, R.

10.1101/2025.05.13.653488 — systems biology — Posted on 2025-05-15

2960 Systematic Mapping of Bacterial CRISPRa Design Rules and Implications for Synergistic Gene Activation

Kiattisewee, C.; Karanjia, A. V.; Cardiff, R. A. L.; Olander, K. E.; Leejareon, P.; Alvi, S. S.; Carothers, J. M.; Zalatan, J. G.

10.1101/2025.05.14.654134 — synthetic biology — Posted on 2025-05-15

2961 Peptide nucleic acid (PNA) and DNA hybrid three-way junctions and mesojunctions

Madhanagopal, B. R.; Patel, A.; Talbot, H.; Geary, J. A.; Ganesh, K. N.; Chandrasekaran, A. R.

10.1101/2025.05.15.653195 — synthetic biology — Posted on 2025-05-15

2962 Alternatively-Spliced CAMKK2 isoforms drive differential metabolic stress response and the regulation of ferroptosis

Cheng, S.; Kim, H.; Fahmi, N. A.; Park, M.; Canny, M.; Kukreja, R.; Beckermann, E. J.; Latham, M.; Zhang, W.; Yong, J.

10.1101/2025.05.13.653837 — biochemistry — Posted on 2025-05-15

2963 Antibody targeting the anti-parallel topology of human telomeric G-quadruplex DNA

Reda, N.; Muret, S.; Esteve, C.; Derathe, E.; Susanto, M.-F.; Pitot, E.; Bonnet, H.; Lavergne, T.; Gomez, D.; Dejeu, J.; Scaramozzino, N.; Defrancq, E.

10.1101/2025.05.13.653741 — biochemistry — Posted on 2025-05-15

2964 An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

Lin, Z.; Xie, Y.; Gongora, J.; Liu, X.; Zahn, E.; Palai, B. B.; Ramirez, D.; Searfoss, R.; Vitorino, F. N.; Karki, R.; Dann, G. P.; Zhao, C.; Han, X.; Mactaggart, B.; Lan, X.; Fu, D.; Greenberg, L.; Zhang, Y.; Lavine, K. J.; Greenberg, M. J.; Lyu, D.; Kashina, A. S.; Garcia, B. A.

10.1101/2024.06.01.596974 — biochemistry — Posted on 2025-05-15

2965 An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks

Cao, Y.; Wang, Y.; Badar, J.; Palek, M.; Jaber, K.; Faca, V. M.; Huang, T.; Celik, E.; Macurek, L.; Smolka, M. B.

10.1101/2025.05.13.652823 — biochemistry — Posted on 2025-05-15

2966 Comparative Virome Profiling and Discovery of Novel Viruses in Managed and Wild Bees using RNA-seq

Zhao, Z.; Farrell, M. C.; Pudasaini, R.; Marvin, J.; Rehan, S.; Li-Byarlay, H.

10.1101/2025.04.27.650873 — genomics — Posted on 2025-05-15

2967 Kinship estimation bias carries over to heritability estimation bias using variance components

Hou, Z.; Ochoa, A.

10.1101/2025.05.13.653659 — genetics — Posted on 2025-05-15

2968 Eukaryotic biodiversity and ecological networks from the surface to the mesopelagic in the Northwest Atlantic Slope Water

Yang, N.; Allan, E. A.; Stover, S. E.; Grassian, B. D.; Sosik, H. M.; Llopiz, J. K.; Govindarajan, A. F.

10.1101/2025.05.12.653512 — ecology — Posted on 2025-05-15

2969 A Short 63-Nucleotide Element Promotes Efficient circRNA Translation

Biagi, M. C.; Giuliani, A.; Grandioso, A.; Bozzoni, I.; Di Timoteo, G.

10.1101/2025.05.13.653105 — molecular biology — Posted on 2025-05-15

2970 Data-independent immunopeptidomics discovery of low-abundant bacterial epitopes

Willems, P.; Staes, A.; Demichev, V.; Devos, S.; Impens, F.

10.1101/2025.05.14.653952 — molecular biology — Posted on 2025-05-15

2971 Cellular metabolic state controls mitochondrial RNA kinetics

Reardon, S. D.; Bautista, C.; Cole, S. C.; Cicero, J.; Mishanina, T. V.

10.1101/2025.05.13.653903 — molecular biology — Posted on 2025-05-15

2972 WHEP Domain of Glycyl-tRNA Synthetase Regulates Neuropilin 1 Binding and Vascular Permeability

Tong, Y.; Gioelli, N.; Zhang, H.; Dumitru, C. D.; Kanaji, S.; Horii, M.; Cheong, K. N.; Zhou, J.; Bolon, B.; Bai, G.; Serini, G.; Kanaji, T.; Yang, X.-L.

10.1101/2025.05.14.654074 — molecular biology — Posted on 2025-05-15

2973 Autonomous division of the outer membrane in Gram-negative bacteria

Basurto De Santiago, C.; Nan, B.

10.1101/2025.05.15.654258 — microbiology — Posted on 2025-05-15

2974 Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef

Agarwal, M.; Lai, K. K.; Wilt, I.; Majdoul, S.; Jolley, A. A.; Lewinski, M.; Compton, A. A.

10.1101/2025.05.15.654345 — microbiology — Posted on 2025-05-15

2975 Interplay between SpaO variants shapes the architecture of the Salmonella type III secretion sorting platform

Soto, J. E.; Wang, T.; Galan, J. E.; Lara-Tejero, M.

10.1101/2025.05.15.654217 — microbiology — Posted on 2025-05-15

2976 The effect of particle size on wheat bran fermentation by human gut microbiota

Fricker, A. D.; Deemer, D. G.; Tuncil, Y. E.; Thakkar, R.; Marcia, A. R.; Emsley, C. W.; Lindemann, S. R.

10.1101/2025.05.15.654185 — microbiology — Posted on 2025-05-15

2977 Induced tolerance to UV stress drives survival heterogeneity in isogenic E. coli cell populations

Ichikawa, S.; Tanoue, M.; Takeuchi, J.; Matsuo, E.; Shimada, Y.; Singh, A.

10.1101/2025.05.14.654146 — microbiology — Posted on 2025-05-15

2978 A novel strategy to mitigate Corynebacterium bovis-associated hyperkeratosis (CAH) in athymic nude mice

Michelson, A.; Cheleuitte-Nieves, C.; Nickerson, K.; Dobtsis, I.; Miranda, I.; Ricart Arbona, R. J.; Wipf, J.; Lipman, N. S.

10.1101/2025.05.15.654331 — microbiology — Posted on 2025-05-15

2979 TCR repertoire analysis quantifies effect of irradiation to homeostasis of iNKT cell development in the thymus of mice

Kaneko, K. B.; Hayama, M.; Uchida, N.; Miyao, T.; Akiyama, N.; Akiyama, T.; Kobayashi, T. J.

10.1101/2025.05.12.653114 — immunology — Posted on 2025-05-15

2980 AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

Amer, H. M.; Shamseldin, M. M.; Faber, S.; Eltobgy, M.; Webb, A.; El-Mergawy, R.; Chamblee, M.; Perez, R.; Whitham, O.; Badr, A.; Gupta, G.; Omran, J.; Bissel, D.; Yount, J.; Cormet-Boyaka, E.; Boyaka, P. N.; Li, J.; Zhang, X.; Peeples, M. E.; KC, M.; Pietrzak, M.; Seveau, S.; Kokiko-Cochran, O.; Amer, M.; Barrientos, R. M.; Schamess, A.; Oltz, E.; Amer, A. O.

10.1101/2025.05.14.654036 — neuroscience — Posted on 2025-05-15

2981 Magnetic Fields Influence Visual Responses in Mice

Semo, M.; Hughes, S.; Smylie, N. J.; Patton, A. P.; Pothecary, C. A.; Tam, S. K. E.; Buckland, J.; Brown, L. A.; Reardon, P. K.; Bannerman, D. M.; Hastings, M. H.; Peirson, S. N.

10.1101/2025.05.12.653455 — neuroscience — Posted on 2025-05-15

2982 Unusually Broad-spectrum small-molecule sensing using a single protein scaffold

Tian, H.; Beltran, J.; George, W.; Lenert-Mondou, C.; Seder, N.; Davis, Z. I.; Swift, S. D.; Whitehead, T. A.; Girke, T.; Wheeldon, I.; Cutler, S. R.

10.1101/2025.05.15.654352 — synthetic biology — Posted on 2025-05-15

2983 Sustainable production of plastic-degrading enzymes in Chlamydomonas pacifica

Diaz, C. J.; Dutra Molino, J. V.; Saucedo, B.; Kang, K.; do Espirito Santo, E.; Tessman, M.; Gupta, A.; Burkart, M. D.; Simkovsky, R.; Mayfield, S.

10.1101/2025.05.14.654053 — synthetic biology — Posted on 2025-05-15

2984 Pharmacokinetic-Pharmacodynamic Trade-offs in SARS-CoV-2 Main Protease Inhibitors Unveiled through Machine Learning and Molecular Dynamics Simulations

Souza, A. S. d.; Amorim, V. M. d. F.; Soares, E. P.; de Souza, R. F.; Guzzo, C. R.

10.1101/2025.05.14.654028 — pharmacology and toxicology — Posted on 2025-05-15

2985 Identification of disease-specific vulnerability states at the single-cell level

D'Antuono, M.; Sharp, M.; Chowdary, R.; Ivan, M. E.; Komotar, R. J.; Suter, R. K.; Ayad, N. G.

10.1101/2024.12.04.626873 — cancer biology — Posted on 2025-05-15

2986 Image-Based Quantitative Single-Cell Method Suggests Increase of Global Chromatin Accessibility in Tumor Compared to Normal Cells lines

Commane, M.; Jadhav, V.; Leonova, K.; Buckley, B.; Withers, H.; Gurova, K.

10.1101/2024.09.05.611456 — cancer biology — Posted on 2025-05-15

2987 Overcoming myeloid-driven resistance to CAR T therapy by targeting SPP1

Gholamin, S.; Natri, H. M.; Zhao, Y.; Xu, S.; Aftabizadeh, M.; Comin-Anduix, B.; Saravanakumar, S.; Masia, C.; Wong, R. A.; Peter, L.; Chung, M.-i.; Mee, E. D.; Aguilar, B.; Starr, R.; Torrejon, D. Y.; Alizadeh, D.; Wu, X.; Kalbasi, A.; Ribas, A.; Forman, S.; Badie, B.; Banovich, N.; Brown, C.

10.1101/2025.04.01.646202 — cancer biology — Posted on 2025-05-15

2988 Cleared tissue dual-view oblique plane microscopy

Dvinskikh, L.; Sparks, H.; Ennis, D.; Sarnataro, R.; Carreno, D.; Riglar, D. T.; Cunnea, P.; McNeish, I. A.; Dunsby, C.

10.1101/2025.05.12.653537 — biophysics — Posted on 2025-05-15

2989 GFP-Free Live-Neuron Quantitative Imaging Reveals Compartmentalization and Growth Dynamics of PolyQ Aggregates

Bi, X.; Lin, L.-E.; Miao, K.; Wei, L.

10.1101/2025.05.12.653542 — biophysics — Posted on 2025-05-15

2990 Deconstructing the Cancer Epigenome using Reduced Representation Bisulfite Sequencing (RRBS)

Glendinning, N.; Chung, D.; Hardiman, G.

10.1101/2025.05.12.653548 — bioinformatics — Posted on 2025-05-15

2991 Integrating the ENCODE blocklist for machine learning quality control of ChIP-seq with seqQscorer

Albrecht, S.; Krämer, C.; Röchner, P.; Mayer, J. U.; Rothlauf, F.; Andrade-Navarro, M. A.; Sprang, M.

10.1101/2025.05.12.653555 — bioinformatics — Posted on 2025-05-15

2992 A computational strategy to uncover fusion genes in prostate cancer cell lines

Morgan, R. A.; Hardiman, G.

10.1101/2025.05.12.653554 — bioinformatics — Posted on 2025-05-15

2993 A Dual-Readout Photonic Sensor for Simultaneous Measure-ment of Enzyme Activity and Concentration

Butt, J. N.; Steiner, D. J.; Bryan, M. R.; Mann, K. E.; Miller, B.

10.1101/2025.05.12.653528 — bioengineering — Posted on 2025-05-15

2994 DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation

Yonezawa, T.; Rutter, J.; Ramabadran, R.; Sundaramurthy, V.; Datar, G.; Slabicki, M.; Goodell, M. A.

10.1101/2025.03.05.641683 — biochemistry — Posted on 2025-05-15

2995 Identifying genomic adaptation to local climate using a mechanistic evolutionary model

Goel, N.; Bossu, C. M.; Van Ee, J. J.; Zavaleta, E.; Ruegg, K. C.; Hooten, M. B.

10.1101/2024.11.21.624744 — genomics — Posted on 2025-05-15

2996 Systematic Background Selection for Enhanced Contrastive Dimension Reduction

Park, K.; Sun, Z.; Liao, R.; Bresnick, E. H.; Keles, S.

10.1101/2025.05.12.653541 — genomics — Posted on 2025-05-15

2997 Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase in C. elegans

Longtine, C.; Frenk, S.; Lister-Shimauchi, E. H.; Ahmed, S.

10.1101/292722 — genetics — Posted on 2025-05-15

2998 Narrowed host ranges do not constrain future host range expansion in RNA phage phi6

Andrews, T.; Isaac, A.; Duffy, S.

10.1101/2025.05.12.653482 — evolutionary biology — Posted on 2025-05-15

2999 Phylogenetic relationships of ATM polymorphic loci haplotypes in Eurasian and African populations

Olkova, M.; Koshel, S.; Ponomarev, G.; Alimov, A.

10.1101/2025.05.10.652950 — evolutionary biology — Posted on 2025-05-15

3000 Temperature-dependent predation predicts a more reptilian future

Grady, J. M.; Amme, J. L.; Bhaskaran-Nair, K.; Sinha, V.; Brunwasser, S. J.; Read, Q. D.; Record, S.; Dell, A. I.; Hengen, K. B.

10.1101/2024.09.19.613816 — ecology — Posted on 2025-05-15

3001 Sediment-associated processes account for most of the spatial variation in ecosystem respiration in the Yakima River basin

Garayburu-Caruso, V.; Kaufman, M.; Forbes, B.; Hall, R.; Laan, M.; Chen, X.; Lin, X.; Fulton, S.; Renteria, L.; Fang, Y.; Son, K.; Stegen, J. C.

10.1101/2024.03.22.586339 — ecology — Posted on 2025-05-15

3002 Observing adaptation of duckweeds to their local microbiome depends on local pondwater

Rose, A.; O'Brien, A.

10.1101/2025.05.12.653557 — ecology — Posted on 2025-05-15

3003 Using a sequential sampling algorithm to apply the niche-neutral model to species occurrence patterns

Kristensen, N. P.; Sin, Y. C. K.; Lim, H. S.; Rheindt, F. E.; Chisholm, R. A.

10.1101/2024.11.07.622409 — ecology — Posted on 2025-05-15

3004 RDAforest: identifying environmental drivers of polygenic adaptation.

Matz, M. V.; Black, K. L.

10.1101/2024.10.21.619525 — ecology — Posted on 2025-05-15

3005 Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I

Leng, H.; jiang, j.; Gassner, K.; Midha, S.; Justo-Mendez, R.; Zheng, J.; Hall, T.; Luo, L.; West, S. D.; Vincent, T. L.; Wann, A.; Patel, K. A.; Poulton, J.; O'Callaghan, C. A.; Lechuga-Vieco, A. V.; Simon, A. K.

10.1101/2025.05.02.651799 — cell biology — Posted on 2025-05-15

3006 nERdy: network analysis of endoplasmic reticulum dynamics

Samudre, A.; GAO, G.; Cardoen, B.; Joshi, B.; Nabi, I. R.; Hamarneh, G.

10.1101/2024.02.20.581259 — cell biology — Posted on 2025-05-15

3007 Reduced cell-substrate adhesion formation promotes cell migration in Dictyostelium

Fierro Morales, J. C.; Nguyen, T.; Nepal, S.; Redfearn, C.; Gale, B. K.; Titus, M. A.; Roh-Johnson, M.

10.1101/2024.03.19.585764 — cell biology — Posted on 2025-05-15

3008 Does local adaptation influence thermal responses in red coral populations across depth gradients? Transcriptomic insights for effective conservation.

Ramirez-Calero, S. P.; Garrabou, J.; Suresh, S.; Gut, M.; Jou, M.; Sarropoulou, X.; Lopez-Sendino, P.; Zabala, M.; Ledoux, J.-B.

10.1101/2025.05.12.653513 — molecular biology — Posted on 2025-05-15

3009 Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria in a mouse challenge model

Nepal, Y.; Francian, A.; Flores-Garcia, Y.; Roberts, B. T.; David, S. A.; Zavala, F.; Chackerian, B.

10.1101/2025.03.03.641239 — immunology — Posted on 2025-05-15

3010 Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability

Ye, S.; Dave, A.; Salami, A.; Ziaei, M.

10.1101/2025.05.12.653474 — neuroscience — Posted on 2025-05-15

3011 Nanoporous Microelectrodes for Neural Electrophysiology Recordings in Organotypic Culture

Lutsyk, P.; Goswami, D.; Greenhill, S. D.

10.1101/2025.05.12.653414 — neuroscience — Posted on 2025-05-15

3012 Skeletonization of neuronal processes using Discrete Morse techniques from computational topology

Banerjee, S.; Stam, C.; Tward, D. J.; Savoia, S.; Wang, Y.; Mitra, P. P.

10.1101/2025.05.12.653477 — neuroscience — Posted on 2025-05-15

3013 Information processing in the Hand Laterality Judgement Task: Fundamental differences between dorsal and palmar views revealed by a Forced Response paradigm

Moreno-Verdu, M.; Waltzing, B. M.; McAteer, S. M.; Van Caenegem, E. E.; Hamoline, G.; Hardwick, R. M.

10.1101/2025.03.17.643645 — neuroscience — Posted on 2025-05-15

3014 Summation of contrast across the visual field: a common "fourth root" rule holds from the fovea to the periphery

Baldwin, A. S.; Meese, T. S.

10.1101/2025.05.06.649158 — neuroscience — Posted on 2025-05-15

3015 Automated high-throughput patch clamp electrophysiology of hiPSC-derived neuronal models

Farinelli, F.; Ostlund, I.; Sripathy, S. R.; Das, D.; Shim, G.; Myung, S.; Straub, R. E.; Maher, B. J.

10.1101/2025.05.12.653142 — neuroscience — Posted on 2025-05-15

3016 Data Heterogeneity Limits the Scaling Effect of Pretraining Neural Data Transformers

Jiang, L. P.; Chen, S.; Tanumihardja, E.; Han, X.; Shi, W.; Shea-Brown, E.; Rao, R. P. N.

10.1101/2025.05.12.653551 — neuroscience — Posted on 2025-05-15

3017 APOE4-induced patterned behavioral decline and neurodegeneration requires endogenous tau in a C. elegans model of Alzheimer's disease

Pierce-Shimomura, J.; Cardona, E. A.; Wu, Z.; Bolton, B. M.; Sarinay Cenik, E.

10.1101/2025.05.06.652574 — neuroscience — Posted on 2025-05-15

3018 Coding odor modality in piriform cortex efficiently with low-dimensional subspaces: a Shared Covariance Decoding approach

Selb, D. M.; Barreiro, A. K.; Gautam, S. H.; Shew, W.; Ly, C.

10.1101/2024.06.26.600792 — neuroscience — Posted on 2025-05-15

3019 Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

Kole, K.; Kole, M. H. P.

10.1101/2025.05.12.653506 — neuroscience — Posted on 2025-05-15

3020 Recurrent cortical networks encode natural sensory statistics via sequence filtering

Deveau, C.; Zhou, Z.; LaFosse, P. K.; Deng, Y.; Mirbagheri, S.; Steinmetz, N.; Histed, M. H.

10.1101/2024.02.24.581890 — neuroscience — Posted on 2025-05-15

3021 Amyloid-disrupted hippocampal spatial tuning and splitter cell activity leads to memory deficits in a spatial alternation task

Li, Y.; Go, M. A.; Zhang, H.; Schultz, S. R.

10.1101/2025.02.05.636661 — neuroscience — Posted on 2025-05-15

3022 Human- and Rodent-derived Extracellular Vesicles Mediate the Spread of Pathology in MSA-like Models

Vetsi, M.; Dionysopoulou, D.; Mavroeidi, P.; Arvanitaki, F.; Tsaka, G.; Lopez, E. M.; Giannopoulou, M.; Fortis, S.; Kriebardis, A.; Becker, S.; Zachrdla, M.; Omori, M.-S. C.; Kloukina, I.; Tremi, I.; Havaki, S.; Gorgoulis, V.; Stefanova, N.; Jensen, P. H.; Zweckstetter, M.; Xilouri, M.

10.1101/2025.05.12.653337 — neuroscience — Posted on 2025-05-15

3023 PEtab Select: specification standard and supporting software for automated model selection

Pathirana, D.; Bergmann, F. T.; Doresic, D.; Lakrisenko, P.; Persson, S.; Neubrand, N.; Timmer, J.; Kreutz, C.; Binder, H.; Cvijovic, M.; Weindl, D.; Hasenauer, J.

10.1101/2025.05.12.653312 — systems biology — Posted on 2025-05-15

3024 G Protein Coupled Estrogen Receptor Signaling Maintains β Cell Identity in Female Mice

McLaughlin, M. R.; Krishnan, P.; Wu, W.; Rostron, C.; Orr, K.; Udari, L.; Del Carmen Aquino, J.; Fisher, A.; Kono, T. M.; Kua, K. L.; Evans-Molina, C.

10.1101/2025.05.12.652914 — physiology — Posted on 2025-05-15

3025 Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

Suter, R. K.; Jermakowicz, A.; Veeramachaneni, R.; D'Antuono, M.; Zhang, L.; Chowdary, R.; Kaeppeli, S.; Sharp, M.; Palwai, P.; Stathias, V.; Baker, G.; Ruiz, L. C.; Walters, W.; Cepero, M.; Burgenske, D.; Reilly, E. B.; Oleksijew, A.; Anderson, M. G.; Williams, S. L.; Ivan, M. E.; Komotar, R. J.; De La Fuente, M. I.; Stein, G.; Kesari, S.; Sarkaria, J. N.; Schürer, S.; Ayad, N. G.

10.1101/2025.05.15.654044 — cancer biology — Posted on 2025-05-15

3026 Cellular characterization of the peritumoral brain zone of glioblastomas: heterogenous nature and clinical relevance.

deDios, O.; Romero, J.; Ramirez-Gonzalez, M.; Herranz-Sanchez, B.; Avis, A.; Ramos, A.; Sepulveda-Sanchez, J. M.; Gargini, R.; Segura-Collar, B.; Velilla, G.; Melendez, B.; Gonzalez, P.; Jimenez-Roldan, L.; Garcia-Posadas, G.; Hernandez-Lain, A.; Perez-Nunez, A.; Sanchez-Gomez, P.

10.1101/2025.03.09.633849 — cancer biology — Posted on 2025-05-15

3027 Electrical control of the transduction channels' gating force in sensory hair cells.

Joliot, A.; Stickel, L.; Martin, P.

10.1101/2024.12.13.628311 — biophysics — Posted on 2025-05-15

3028 Voxelotor (Oxbryta) Binds Multiple Hemoglobin Sites and Influences Protein Structure

Tamanaha, M. d. l. C.; Cabrera, E. F.; Sargeant, J.; Gershon, P. D.; Russell, P. P. S.; Cocco, M. J.

10.1101/2025.05.12.653546 — biophysics — Posted on 2025-05-15

3029 Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of chromatin arrays

Gao, J.; Li, H.; Tan, S.; Zhou, R.; Lee, T.-H.

10.1101/2025.05.09.653121 — biophysics — Posted on 2025-05-15

3030 GPU-accelerated homology search with MMseqs2

Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.

10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-05-15

3031 Multiplexed Data-Independent Acquisition (mDIA) to Profile Extracellular Vesicle Proteomes

Liu, Y.-K.; Miller, N.; Hadisurya, M.; Zhang, Z.; Tao, W. A.

10.1101/2025.05.12.653483 — biochemistry — Posted on 2025-05-15

3032 Chaotic behavior influenced by an environmental parameter in simulated C. elegans populations

Bergstrom, E.; Scharf, A.

10.1101/2025.05.13.653639 — ecology — Posted on 2025-05-15

3033 High-Sensitivity Top-Down Proteomics Reveals Enhanced Maturation of Micropatterned Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Wilson, M. C.; Josvai, M.; Walters, J. K.; Lawson, J.; Rossler, K. J.; Gao, Z.; Zhu, Y.; Kamp, T. J.; Crone, W.; Eckhardt, L. L.; Ge, Y.

10.1101/2025.05.12.653499 — molecular biology — Posted on 2025-05-15

3034 HIV-1 Amplifies IL-8 Response Of Human Stellate Cells To Gram-Positive Microbial Products Via H4K5 Histone Acetylation

Zhang, L.; Ali, R. O.; Chamroonkul, N.; Tabrizian, P.; Schwartz, M.; Gunasekaran, G.; Schiano, T.; Fiel, M. I.; Ward, S.; Bansal, M. B.

10.1101/2025.05.12.653460 — immunology — Posted on 2025-05-15

3035 Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models

Martin, A. K.; Hedberg, J.; Hernandez Aguirre, I.; Saini, U.; Kim, D.; Kim, Y.; Dhital, R.; Cassady, K. A.

10.1101/2025.05.12.653429 — immunology — Posted on 2025-05-15

3036 Experimental evidence for reproduction to increase mitochondrial respiration, but decrease mitochondrial efficiency, in females of a short-lived bird

Beccardi, M.; Salmon, P.; Vedder, O.

10.1101/2025.05.12.653466 — physiology — Posted on 2025-05-15

3037 Extending the Gaussian Network Model: Integrating Local, Allosteric, and Structural Factors for Improved Residue-Residue Correlation Analysis

Erman, B.

10.1101/2025.05.12.653468 — biophysics — Posted on 2025-05-15

3038 Defining conservation units in a highly diverse species: A case on Arctic charr

Fenton, S.; Bean, C. W.; Martin, S. A. M.; Poultney, S. J.; Smith, A.; de Eyto, E.; Elmer, K. R.; Adams, C. E.

10.1101/2025.05.12.653098 — genomics — Posted on 2025-05-15

3039 CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans

Draber, P.; Semberova, T.; Pribikova, M.; Kissiova, H.; Trivic, T.; Stepanek, O.

10.1101/2025.05.12.653457 — immunology — Posted on 2025-05-15

3040 The plant-time-bender model: predicting yield through wheat's perception of time

Roth, L.; Herrera, J. M.; Levy Häner, L.; Pellet, D.; Fossati, D.; Boss, M.; Chen, X.; Nousi, P.; Volpi, M.

10.1101/2025.05.12.653430 — genomics — Posted on 2025-05-15

3041 African Cichlid Lake Radiations Recapitulate Riverine Axial Morphologies Through Repeated Exploration of Morphospace

Bucklow, C. V.; Ribeiro, E. D.; Ronco, F.; Vranken, N.; Oliver, M. K.; Salzburger, W.; Stiassny, M.; Benson, R.; Verd, B.

10.1101/2025.05.13.653847 — evolutionary biology — Posted on 2025-05-15

3042 Eukaryotic biodiversity and ecological networks from the surface to the mesopelagic in the Northwest Atlantic Slope Water

Yang, N.; Allan, E. A.; Stover, S. E.; Grassian, B. D.; Sosik, H. M.; Llopiz, J. K.; Govindarajan, A. F.

10.1101/2025.05.12.653512 — ecology — Posted on 2025-05-15

3043 Parallels in the Regulatory Landscape of Dimorphic Female and Male Genital Structures in Drosophila melanogaster

McQueen, E.; Rice, G.; Pillai, S.; Saleh Ziabari, O.; Vincent, B. J.; Rebeiz, M.

10.1101/2025.05.12.653573 — developmental biology — Posted on 2025-05-15

3044 Assessing analysis methods of brain synchrony in social interaction: Simulation-based comparison

Morimoto, S.; Minagawa, Y.

10.1101/2025.05.12.653588 — neuroscience — Posted on 2025-05-15

3045 Light-induced structural adaptation of the bundle-shaped phycobilisome from thylakoid-lacking cyanobacterium Gloeobacter violaceus

Ma, J.; You, X.; Sun, S.; Sui, S.-F.

10.1101/2025.05.12.653420 — biophysics — Posted on 2025-05-15

3046 ngsAMOVA: A Probabilistic Framework for Analysis of Molecular Variance, dXY and Neighbor-Joining Trees with Low Depth Sequencing Data

Altinkaya, I.; Zhao, L.; Nielsen, R.; Korneliussen, T. S.

10.1101/2025.05.12.653431 — bioinformatics — Posted on 2025-05-15

3047 Community-promoted antibiotic resistance genes show increased dissemination among pathogens

Lund, D.; Johnning, A.; Holmström, M.; Varghaei, L.; Inda-Diaz, J. S.; Bengtsson-Palme, J.; Kristiansson, E.

10.1101/2025.05.12.653433 — bioinformatics — Posted on 2025-05-15

3048 A close unicellular relative reveals aggregative multicellularity was key to the evolution of animals

Li, R.; Dharamshi, J. E.; Kwok, K.; Ruiz-Trillo, I.; Gerdt, J. P.

10.1101/2025.05.14.654023 — biochemistry — Posted on 2025-05-15

3049 NvashA function reveals temporal differences in neural subtype generation in cnidarians

Havrilak, J. A.; Cheng, M.; Al-Shaer, L.; Leach, W. B.; Yagodich, M.; Faltine-Gonzalez, D. Z.; Layden, M. J.

10.1101/2025.05.12.653478 — developmental biology — Posted on 2025-05-15

3050 Hematopoietic Single Cell Atlas Reveals a Diverse Repertoire of Lymphoid Cells in Larval Zebrafish

Nizhnik, A.; Ulloa, B. A.; Jackson, K.; Zheng, D.; Bowman, T. V.

10.1101/2025.05.12.653589 — developmental biology — Posted on 2025-05-15

3051 The effects of estrogen on cardiac progenitor cell-derived extracellular vesicles in enhancing cardiac protection through promoting tissue repair and regeneration

Aksoy, Z. B.; Aydos, D.; Kocakaya, E.; Uyar, R.; Turan, B.; Bitirim, C. V.

10.1101/2025.05.12.653385 — molecular biology — Posted on 2025-05-15

3052 Temporal and spatial profiling of ALKBH5 activity through NAIL-MS and compartmentalized RNA Isolation

Wesseling, H.; Kaiser, S.

10.1101/2025.05.12.653425 — molecular biology — Posted on 2025-05-15

3053 The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events

Onimus, O.; Arrivet, F.; Le Borgne, T.; Perez, S.; Castel, J.; Ansoult, A.; Bertrand, B.; Mashhour, N.; de Almeida, C.; Bui, L.-C.; Vandecasteele, M.; Luquet, S.; Venance, L.; Heck, N.; Marti, F.; Gangarossa, G.

10.1101/2025.05.12.653303 — neuroscience — Posted on 2025-05-15

3054 Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer

Keumoe, R.; Kouipou, R. M. T.; Madiesse, E. A. K.; Fokou, J. B. H.; Dize, D.; Fokou, P. V. T.; Kamdem, B. P.; Makembe, A. H. E.; Njionhou, M. S. N.; Ghoshal, A.; Kundu, A.; Laleu, B.; Boyom, F. F.

10.1101/2025.05.12.653443 — pharmacology and toxicology — Posted on 2025-05-15

3055 Promising protocol for in vivo experiments with betulin

Siman, P.; Bezrouk, A.; Ticha, A.; Kozakova, H.; Hudcovic, T.; Kucera, O.; Niang, M.

10.1101/2025.05.12.653392 — pharmacology and toxicology — Posted on 2025-05-15

3056 Probing as a new technique to assess single-cell RNA-seq batch correction

Codice', F.; Fariselli, P.; Raimondi, D.

10.1101/2025.05.12.653389 — bioinformatics — Posted on 2025-05-15

3057 Rotiferometer: an automated system for quantification of rotifer cultures

Diouf, A.; Bereziat, L.; Nodier, D.; Amaral, M.; Haliyo, S.; MANNIOUI, A.

10.1101/2025.05.12.653399 — bioengineering — Posted on 2025-05-15

3058 Alpha-tocopherol conjugated DNA tetrahedron with enhanced cellular uptake and selective cytotoxicity for cancer therapeutics

Chithra, P.; Vaswani, P.; Bhatia, D. D.

10.1101/2025.05.12.653403 — bioengineering — Posted on 2025-05-15

3059 Conformational dynamics of the bacterial E3 ligase SspH1

Kennedy, C. R.; Esposito, D.; House, D.; Rittinger, K.

10.1101/2025.05.12.653404 — biochemistry — Posted on 2025-05-15

3060 Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution.

Longley, H.; Fraser, C.; Wymant, C.; Lythgoe, K.

10.1101/2025.05.12.653435 — evolutionary biology — Posted on 2025-05-15

3061 Slow RNAPII elongation enhances naive-pluripotency rewiring while preserving replication fork speed

Martin-Virgala, S.; Segura, J.; Gallego, A.; Isoler-Alcaraz, J.; Schermelleh, L.; Gomez, M.

10.1101/2025.05.12.653265 — molecular biology — Posted on 2025-05-15

3062 Automated behavior classification of julius seizure mutants in Drosophila reveals stereotyped seizure stages with genotype specificity

Zhang, H.; Deitcher, D. L.; Lau, C. G.

10.1101/2025.05.13.653908 — neuroscience — Posted on 2025-05-15

3063 Absence of Systematic Effects of Internalizing Psychopathology on Learning Under Uncertainty

Satti, M. H.; Wille, K.; Nassar, M. R.; Cichy, R. M.; Schuck, N. W.; Dayan, P.; Bruckner, R.

10.1101/2025.05.12.653409 — neuroscience — Posted on 2025-05-15

3064 Proteomics-based models of gene expression and cellular control of cotton fiber development

Lee, Y.; Yang, P.; Rani, H.; Miller, G.; Grover, C. E.; Swaminathan, S.; Zabotina, O. A.; Wendel, J. F.; Xie, J.; Szymanski, D. B.

10.1101/2025.02.05.636703 — plant biology — Posted on 2025-05-15

3065 Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis

Anderson, S. E.; Hymel, L. A.; Zhang, H.; McKinney, J. M.; Turner, T. C.; Mohiuddin, M.; Han, W. M.; Lee, N. H.; Choi, J. J.; Jeong, G.; Greenwood, E.; Chatterjee, P.; Lee, S.; Gibson, G.; Wood, L. B.; Botchwey, E. A.; Jang, Y. C.; Willett, N. J.

10.1101/2025.05.11.653339 — pathology — Posted on 2025-05-15

3066 Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma

van Oost, S.; Meijer, D. M.; Erdem, Z. B.; IJsselsteijn, M. E.; Roelands, J.; Lam, S. W.; Boejharat, M. S.; van den Akker, B. E. W. M.; van der Breggen, R.; Briaire-de Bruijn, I. H.; Hawinkels, L. J. A. C.; Kruiswijk, A. A.; van der Ploeg, M.; Wijers-Koster, P. M.; Haas, R. L.; van de Sande, M. A. J.; de Miranda, N. F. C. C.; Bovee, J. V. M. G.

10.1101/2025.03.27.645727 — cancer biology — Posted on 2025-05-15

3067 Leveraging Large Language Models for Literature-Driven Prioritization of Protein Binding Pockets

Stratiichuk, R.; Melnychenko, M.; Koleiev, I.; Voitsitskyi, T.; Vladyslav, H.; Shevchuk, N.; Osrovsky, Z.; Bdzhola, V.; Yesylevskyy, S.; Starosyla, S.; Nafiiev, A.

10.1101/2025.05.13.653394 — biophysics — Posted on 2025-05-15

3068 Autocycler: long-read consensus assembly for bacterial genomes

Wick, R. R.; Howden, B. P.; Stinear, T. P.

10.1101/2025.05.12.653612 — bioinformatics — Posted on 2025-05-15

3069 Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

Broske, B.; Binder, S. C.; McEnroe, B. A.; Kempchen, T. N.; Fandrey, C. I.; Messmer, J. M.; Tan, E.; Konopka, P.; Ferber, D.; Yong, M. C. R.; Kleinert, M.; Hoch, A.; Blumenstock, K.; Tödtmann, J. M. P.; Oldenburg, J.; Rühl, H.; Semaan, A.; Toma, M. I.; Markova, K.; Kobold, S.; Rollenske, T.; Geyer, M.; Menzel, S.; Bald, T.; Schmid-Burgk, J. L.; Hagelueken, G.; Hölzel, M.

10.1101/2025.05.11.652819 — bioengineering — Posted on 2025-05-15

3070 DNA extrusion size determines pathway choice during CAG repeat expansion

Bhatia, M.; Phadte, A. S.; Lakhina, A.; Monte Carlo, A. R.; Barndt, S.; Pluciennik, A.

10.1101/2025.05.12.653571 — biochemistry — Posted on 2025-05-15

3071 Disentangling sex-ratio meiotic drive in Drosophila a century after its original discovery

Katoh, T. K.; Chen, Y.; Takatori, N.; Nozawa, M.

10.1101/2025.05.14.653954 — evolutionary biology — Posted on 2025-05-15

3072 Microevolutionary trends of tooth complexity in the Ibiza wall lizard, Podarcis pityusensis, mirror macroevolutionary trends in squamates

Woodgate, S. C.; Evans, A. R.; Kayed, B.; Perez-Cembranos, A.; Perez-Mellado, V.; Müller, J.

10.1101/2025.05.14.653915 — evolutionary biology — Posted on 2025-05-15

3073 Systematic revision of the speciose sea slug genus Doto (Heterobranchia: Nudibranchia) - from the Mediterranean to South America

Vazquez-Alcaide, D.; Salvador, X.; Giribet, G.; Hooker, Y.; Schrodl, M.; Moles, J.

10.1101/2025.05.14.653969 — evolutionary biology — Posted on 2025-05-15

3074 RG motifs promote piRNA-mediated gene silencing in C. elegans

Wallis, D. C.; Phillips, C. M.

10.1101/2025.05.12.653514 — molecular biology — Posted on 2025-05-15

3075 Macromolecular interactions dictate Polycomb-mediated epigenetic repression

Much, C.; Rajkumar, S. M.; Chen, L.; Cohen, J. M.; Gade, A. R.; Pitt, G. S.; Long, Y.

10.1101/2025.05.15.654236 — molecular biology — Posted on 2025-05-15

3076 High-intensity interval exercise affects explicit sequential motor consolidation with both physical and mental practice

Digonet, G.; Lapole, T.; Gelebart, J.; Bouvier, J.; Blanco, L.; Magaud, J.; Pialoux, V.; Pingon, M.; Stauffer, E.; Debarnot, U.

10.1101/2025.05.10.653061 — neuroscience — Posted on 2025-05-15

3077 Development of the axonal βII-spectrin periodic skeleton requires active cytoskeletal remodelling

Bodas, S.; Mishra, A.; Pullarkat, P.; Ghose, A.

10.1101/2025.02.19.639207 — neuroscience — Posted on 2025-05-15

3078 Humans underestimate their body mass in microgravity: evidence from reaching movements during spaceflight

Zhang, Z.; Tian, Y.; Wang, C.; Jiang, C.; Wang, B.; Yu, H.; Zhao, R.; Wei, K.

10.1101/2025.05.12.653611 — neuroscience — Posted on 2025-05-15

3079 Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes

Liu, Y.; Rao, S.; Hoskins, I.; Geng, M.; Zhao, Q.; Chacko, J.; Ghatpande, V.; Qi, K.; Persyn, L.; Wang, J.; Zheng, D.; Zhong, Y.; Park, D.; Cenik, E. S.; Agarwal, V.; Ozadam, H.; Cenik, C.

10.1101/2024.08.11.607360 — bioinformatics — Posted on 2025-05-15

3080 Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells

Hoch, A.; Fandrey, C. I.; Coventry, B.; Virreira Winter, S.; Geyer, P. E.; Kempchen, T. N.; Ebert, T. S.; Hoelzel, M.; Baker, D.; Schmid-Burgk, J. L.

10.1101/2025.05.11.653342 — bioengineering — Posted on 2025-05-15

3081 Tracking Conditioned Fear in Pair-Housed Mice Using Deep Learning and Real-Time Cue Delivery

Smith, H.; Yu, Z.; Yazigi, P.; Turley, B.; Swiercz, A.; Park, J.; Marvar, P. J.

10.1101/2025.05.10.653260 — animal behavior and cognition — Posted on 2025-05-15

3082 Nucleosome positioning and sensitivity suggest novel functional organization of the purple sea urchin (Strongylocentrotus purpuratus) genome

Munstermann, M. J.; Benoit, J. M.; Karelitz, S. E.; Arambarri, L. N.; Dennis, J. H.; Okamoto, D. K.

10.1101/2025.05.12.653534 — genomics — Posted on 2025-05-15

3083 Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools used in Malaria control

Njoroge, H.; Namuli, L.; Nagi, S. C.; Hernandez-Koutoucheva, A.; McDermott, D. P.; Knight, E.; Gonahasa, S.; Lynd, A. R.; Oruni, A.; Maiteki-Sebuguzi, C.; Opigo, J.; Yeka, A.; Katureebe, A.; Kyohere, M.; Kamya, M.; Dorsey, G.; hemingway, J.; Staedke, S.; Clarkson, C. S.; Miles, A.; Lucas, E. R.; Donnelly, M. J.

10.1101/2025.05.12.653619 — genomics — Posted on 2025-05-15

3084 Variation in phenotypic plasticity in desiccation tolerance is driven by trade-offs, not climate, in Drosophila melanogaster

Kellermann, V.; van Heerwaarden, B.

10.1101/2025.05.12.653617 — evolutionary biology — Posted on 2025-05-15

3085 Negative frequency-dependent selection underlies overyielding through neighbor genotypic effects in Arabidopsis thaliana

Sato, Y.

10.1101/2025.05.14.654149 — evolutionary biology — Posted on 2025-05-15

3086 Species-specific, multifaceted venom resistance in Monodelphis domestica reveals novel physiological behavior of von Willebrand Factor under flow.

Holding, M. L.; Disharoon, D.; Haynes, L. M.; Paruchuri, B. C.; Pontius, M. H. H.; Golden, K.; Shavit, J. A.; Desch, K.; Ginsburg, D.; Sen Gupta, A.; Cruz, Y. P.; Drabeck, D.

10.1101/2025.01.21.634112 — evolutionary biology — Posted on 2025-05-15

3087 Examining the genetic and phenotypic correlation between survival and fecundity in a wild bird

Winder, L. A.; Pick, J.; Schroeder, J.; Simons, M.; Burke, T.

10.1101/2025.05.14.653981 — evolutionary biology — Posted on 2025-05-15

3088 Deep Phenomics of Pattern Recognition Receptor Agonist Specific Activation of Human Blood

Barman, S.; Patel, A.; Kelly, A.; Dowling, D. J.

10.1101/2025.05.12.653280 — immunology — Posted on 2025-05-15

3089 Familial ALS/FTD-associated RNA-Binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitro

Magarotto, M.; Gawne, R. T.; Vilkaite, G.; Beltrami, M.; Mason, A. S.; Chen, H.-J.

10.1101/2025.03.26.645507 — neuroscience — Posted on 2025-05-15

3090 SmartEM: machine-learning guided electron microscopy

Meirovitch, Y.; Chandok, I. S.; Park, C. F.; Potocek, P.; Mi, L.; Sawmya, S.; Li, Y.; Athey, T. L.; Susoy, V.; Karlupia, N.; Wu, Y.; Berger, D. R.; Schalek, R.; Bishop, C.; Xenes, D.; Martinez, H.; Matelsky, J.; Wester, B. A.; Pfister, H.; Schoenmakers, R.; Peemen, M.; Lichtman, J. W.; Samuel, A.; Shavit, N.

10.1101/2023.10.05.561103 — neuroscience — Posted on 2025-05-15

3091 Hierarchical Heterogeneities in Spatio-Temporal Dynamics of the Cytoplasm

Moeckel, C.; Biswas, A.; Reber, S.; Chechkin, A.; Zaburdaev, V.; Guck, J.

10.1101/2025.05.08.652886 — biophysics — Posted on 2025-05-15

3092 Spatial geometry-aware deep learning for deciphering tissue structure from spatially resolved transcriptomics

Li, X.; Jia, X.; Zhao, D.; Xu, J.; Du, G.; Qi, Y.; Chen, Y.; Wu, Y.; Zhu, J.; Wei, F.; Shang, X.

10.1101/2025.05.11.652625 — bioinformatics — Posted on 2025-05-15

3093 AF3Score: A Score-Only Adaptation of AlphaFold3 for Biomolecular Structure Evaluation

Liu, Y.; Yu, Q.; Wang, D.; Chen, M.

10.1101/2025.05.10.653251 — bioinformatics — Posted on 2025-05-15

3094 MARTS-DB: A Database of Mechanisms And Reactions of Terpene Synthases

Engst, M.; Brokes, M.; Calounova, T.; Tajovska, A.; Perkovic, M.; Samusevich, R.; Chatpatanasiri, R.; Pluskal, T.

10.1101/2025.05.11.653183 — bioinformatics — Posted on 2025-05-15

3095 Dotplotic: a lightweight visualization tool for BLAST+ alignments and genomic annotations

Miyazawa, H.; Oda, T.

10.1101/2025.05.12.653581 — bioinformatics — Posted on 2025-05-15

3096 Lossless Pangenome Indexing Using Tag Arrays

Eskandar, P.; Paten, B.; Siren, J.

10.1101/2025.05.12.653561 — bioinformatics — Posted on 2025-05-15

3097 Kinetics of de novo Bone and Bone Marrow Niche Formation with Hybrid Click Cryogels

Lee, S.; Adu-Berchie, K.; Sharda, A. S.; To, T.; Dimitrakakis, N.; Stafford, A.; Sheehan, K.; Johnson, C.; Ijaz, H.; Kwon, P.; Cartwright, M.; Elmehrath, S.; Skolfield, M. C.; White, D.; Williams, M.; Super, M.; Scadden, D. T.; Mooney, D. J.

10.1101/2025.05.12.653550 — bioengineering — Posted on 2025-05-15

3098 Characterization of cytokine treatment on human pancreatic islets by top-down proteomics

Ives, A. N.; Sagendorf, T.; Nierves, L.; Lin, T.-T.; Dirice, E.; Kulkarni, R. N.; Pasa-Tolic, L.; Qian, W.-J.; Fulcher, J. M.

10.1101/2025.05.12.653562 — biochemistry — Posted on 2025-05-15

3099 Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA

Zhang, Z.; Tracy, L.

10.1101/2025.05.11.653319 — genomics — Posted on 2025-05-15

3100 CapTrap-seq: Advancing zebrafish transcriptomic research through high-fidelity full-length RNA sequencing

Kwiatkowska, M.; Blangiewicz, M.; Madry, T.; Carbonell-Sala, S.; Guigo, R.; Uszczynska-Ratajczak, B.

10.1101/2025.05.12.653332 — genomics — Posted on 2025-05-15

3101 Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia

Khalaf, A.; Zhou, C.; Weber, C. C.; Vancaester, E.; Sims, Y.; Makunin, A.; Mathers, T. C.; Absolon, D. E.; Wood, J. M.; McCarthy, S. A.; Jaron, K.; Blaxter, M.; Lawniczak, M. K.

10.1101/2025.05.12.652816 — genomics — Posted on 2025-05-15

3102 First chromosome scale genome of Acrocomia aculeata

Scaketti, M.; Garcia, C. B.; Araujo, J. V. d. S. R.; de Carvalho, I. A. S.; Marroquin, J. A. M.; Riano-Pachon, D. M.; Neto, D. D.; Labate, C. A.; Vicentini, R.; Pinheiro, J. B.; Vianna, S.; Colombo, C.; Zucchi, M. I.

10.1101/2025.05.12.653347 — genomics — Posted on 2025-05-15

3103 Deregulated Myt3 translation predisposes islet β-cells to dysfunction under obesity-induced metabolic stress

Hu, R.; Wang, Y.; Yagan, M.; Xu, Y.; Simmons, A.; Lau, K.; Liu, Q.; Gu, G.

10.1101/2025.05.11.653323 — genetics — Posted on 2025-05-15

3104 Deep homology and design of proteasome chaperone proteins in Candida auris

Rapala, J. R.; Siddiq, M.; Wittkopp, P. J.; O'Meara, M. J.; O'Meara, T. R.

10.1101/2025.05.14.654010 — evolutionary biology — Posted on 2025-05-15

3105 Dissecting contributions of directional and balancing selection to trajectories of mitochondrial haplotype evolution in Drosophila melanogaster.

Kannangara, J.; Connallon, T.; Nogueira Alves, A.; Dowling, D.

10.1101/2025.05.12.653591 — evolutionary biology — Posted on 2025-05-15

3106 A novel model system to address the relevance of aggregation in animal origins

Kin, K.; Alarcon, T.; Bercedo-Saborido, G.; Stepanova, D.; Ruiz-Trillo, I.

10.1101/2025.05.14.653760 — evolutionary biology — Posted on 2025-05-15

3107 Departures from Mendelian inheritance of EPSPS gene copies in a herbicide-resistant weed

Yakimowski, S. B.; Han, L. H.; Dungey, K. F.

10.1101/2025.05.12.653577 — evolutionary biology — Posted on 2025-05-15

3108 Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration

Tan, C.; Liu, Z.; Mao, X.; Zhang, Y.; Li, X.; Pek, N.; Fu, H.; Liu, Y.; Kalinichenko, V. V.; Pryhuber, G. S.; Lu, R.; Lai, L.; Miao, Y.; Guo, M.; Gu, M.

10.1101/2025.05.11.653351 — developmental biology — Posted on 2025-05-15

3109 An efficient protocol to derive primordial germ cell like cells in vitro from murine embryonic stem cells.

Kumar, U.; Kumar, N.; Shekar, P. C.; Thangaraj, K.

10.1101/2025.05.12.653613 — developmental biology — Posted on 2025-05-15

3110 Spontaneous ectopic head formation enables reversal of the body axis polarity in microscopic flatworms

Tratkiewicz, K.; Gasiorowski, L.

10.1101/2025.05.14.653983 — developmental biology — Posted on 2025-05-15

3111 Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via PHACTR1 Regulation

Tay, K. Y.; Wee, H. S.; Nguyen, N.; Autio, M. I.; Wazny, V. K.; Lee, K. L.; Tay, D.; Wang, Y.; Gao, X.; Heng, C. K.; Chan, M. Y.; Foo, R. S.; Lee, J.; Loh, M.; Cheung, C.

10.1101/2025.05.11.653298 — molecular biology — Posted on 2025-05-15

3112 GENOMIC ADAPTATION OF AN AUTOCHTHONOUS CIDER YEAST STRAIN TO BUCKWHEAT AND BARLEY WORT UNDER STRESSFUL BREWING CONDITIONS

Podgorsek, M.; Dobersek, K.; Pas, M.; Tome, M.; Ocvirk, M.; Petrovic, U.; Kosir, I. J.; Cadez, N.

10.1101/2025.05.14.654042 — microbiology — Posted on 2025-05-15

3113 The staphylococcal type VII secretion system effector EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity

Smith, V.; Chandrasekharan, G.; Watkins, K.; Maset, R. G.; Yap, J.; Perrier, S.; Tchoupa, A. K.; Unnikrishnan, M.

10.1101/2023.11.20.567842 — microbiology — Posted on 2025-05-15

3114 Euprymna berryi as a comparative model host for Vibrio fischeri light organ symbiosis

Imes, A. M.; Pavelsky, M.; Badal, K.; Kamp, D. L.; Briseno, J. L.; Sakmar, T.; Vogt, M. A.; Nyholm, S. V.; Heath-Heckman, E.; Grasse, B.; Septer, A. N.; Mandel, M. J.

10.1101/2025.01.10.632448 — microbiology — Posted on 2025-05-15

3115 Robust TCR production for the structural study of TCR-pMHC complexes

Oyon-Olea, L.; Dichiara-Rodriguez, M. G.; Hervas-Stubbs, S.; Erausquin, E.; Lopez-Sagaseta, J.

10.1101/2025.05.12.653033 — immunology — Posted on 2025-05-15

3116 Economic and Social Modulations of Innate Decision-Making in Mice Exposed to Visual Threats

Li, Z.; Wang, J.; Sun, Y.; Li, J.; Li, L.-y.; Li, Y.-t.

10.1101/2025.05.12.653401 — neuroscience — Posted on 2025-05-15

3117 Parkinson's-Linked Synaptojanin 1 Loss in Dopamine Neurons Triggers Synaptic Degeneration and Striatal TH Interneuron Compensation

Mukherjee, B.; Lin, Y.; Liu, M.; Li, Z.; Cao, X.; Cao, M.

10.1101/2025.05.14.653914 — neuroscience — Posted on 2025-05-15

3118 An 'Aha!' moment precedes the strategic response to a visuomotor rotation

Townsend, M.; Warburton, M.; Campagnoli, C.; Mon-Williams, M.; Mushtaq, F.; Morehead, J. R.

10.1101/2025.05.11.653302 — neuroscience — Posted on 2025-05-15

3119 Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology

Nemec, K. M.; Uy, G.; Chaluvadi, V. S.; Purnell, F. S.; Elfayoumi, B.; Byerly, L.; O'Reilly, M. L.; O'Brien, C. A.; Aisenberg, W. H.; Lombroso, S. I.; Guo, X.; Blank, N.; Oon, C. H.; Yaqoob, F.; Temsamrit, B.; Rawat, P.; Thaiss, C. A.; Bailis, W.; Williamson, A. P.; Wang, Q.; Bennett, M. L.; Bennett, F. C.

10.1101/2024.09.18.613629 — neuroscience — Posted on 2025-05-15

3120 NodoMap: a spatio-cellular map of the mouse nodose ganglia

Cheng, S.; Dowsett, G. K. C.; Rainbow, K.; Norton, M.; Roberts, A. G.; Phuah, P.; Bewick, G. A.; Lam, B. Y.; Yeo, G. S. H.; Murphy, K.

10.1101/2025.05.11.653249 — physiology — Posted on 2025-05-15

3121 A hormetic model of rapid cold hardening in Drosophila melanogaster reveals threshold effects on survival and low fertility resilience

Vidrio, J. R.; Hahn, D. A.; Moore, M. P.; Ragland, G. J.

10.1101/2025.05.12.653569 — physiology — Posted on 2025-05-15

3122 Targeting of CIP4-Calcineurin Signalosomes Improves Cardiac Structure and Function After Myocardial Infarction

Samuelsson, A.-M.; Bayer, A. L.; Li, J.; Li, Y.; Lewis, D.; Turcotte, M.; Dodge-Kafka, K.; Alcaide, P.; Kapiloff, M. S.

10.1101/2025.05.12.653597 — physiology — Posted on 2025-05-15

3123 Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression

Ha, H. T.; Kosmynina, S.; Verocq, A.; Ozen, K.; Tekia, I.; Bussy, H.; Sabbah, D.; Goemans, C.; Vandenbempt, V.; Gurzov, E. N.; Singh, S. P.; Baeyens, N.

10.1101/2025.05.11.653296 — pathology — Posted on 2025-05-15

3124 Tongue bite apparatus highlights functional innovation in a 310-million-year-old ray-finned fish

Giles, S.; Kolmann, M. A.; Friedman, M.

10.1101/2025.05.10.653277 — paleontology — Posted on 2025-05-15

3125 Droplet growth, Ostwald's rule, and emergence of order in Fused in Sarcoma

Maksudov, F.; Mugnai, M.; Makarov, D.; Thirumalai, D.

10.1101/2025.05.11.653346 — biophysics — Posted on 2025-05-15

3126 Sequence-Dependent Dynamics of U:U Mismatches in RNA Revealed by Molecular Dynamics Simulations

Krepl, M.; Knappeova, B.; Sponer, J.

10.1101/2025.05.14.654057 — biophysics — Posted on 2025-05-15

3127 Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation

Ausserwoeger, H.; Scrutton, R. M.; Sneideris, T.; Fischer, C. M.; Qian, D.; de Csillery, E.; Baronaite, I.; Saar, K. L.; Bialek, A. Z.; Oeller, M. M.; Krainer, G.; Franzmann, T. M.; Wittmann, S.; Iglesias-Artola, J. M.; Invernizzi, G.; Hyman, A. A.; Alberti, S.; Lorenzen, N.; Knowles, T. P. J.

10.1101/2024.05.23.595321 — biophysics — Posted on 2025-05-15

3128 Artificial Intelligence And First Principle Methods In Protein Redesign: A Marriage Of Convenience?

Cianferoni, D.; Vizarraga Revuelto, D.; Fernandez Escamilla, A. M.; Fita, I.; Hamdani, R.; Reche, R.; Delgado, J.; Serrano Pubul, L.

10.1101/2025.05.12.653318 — bioinformatics — Posted on 2025-05-15

3129 TITANiAN: Robust Prediction of T-cell Epitope Immunogenicity using Adversarial Domain Adaptation Network

Kim, J.; Jung, N.; Lee, J.; Cho, N.-H.; Noh, J.; Seok, C.

10.1101/2025.05.11.653308 — bioinformatics — Posted on 2025-05-15

3130 Forskolin as a multi-target modulator of the oncogenic PI3K/Akt signaling pathway: An in silico integrative GO/KEGG enrichment analysis and network pharmacology

Sarhan, E. M.

10.1101/2025.05.11.653344 — bioinformatics — Posted on 2025-05-15

3131 SynLS: A novel diffusion-transformer framework for generating high-quality wearable sensor time series data to enhance health monitoring

Lin, D.; Ji, Y.; McArt, J.; Li, J.

10.1101/2025.05.11.653212 — bioinformatics — Posted on 2025-05-15

3132 A Multimodal Graph Learning Framework for Versatile Spatial Transcriptomics Analysis with SpatialModal

Li, X.; Zhao, D.; Jia, X.; Du, G.; Xu, J.; Qi, Y.; Chen, Y.; Wu, Y.; Zhu, J.; Wei, F.; Li, M.; Shang, X.

10.1101/2025.05.11.653070 — bioinformatics — Posted on 2025-05-15

3133 Evaluating Foundation Models for In-Silico Perturbation

Liu, X.; Boylan, J.; Bouiller, T.; Solovyeva, E.; Ataman, B.; Hoersch, S.; Jenkins, J.; Devarakonda, M.

10.1101/2025.05.11.653338 — bioinformatics — Posted on 2025-05-15

3134 A Comparative Assessment of edgeR and methylKit Pipelines for DNA Methylation Detection

Munoa Hoyos, I.; Araolaza, M.; Calzado, I.; Albizuri, M.; Subiran, N.

10.1101/2025.05.11.653026 — bioinformatics — Posted on 2025-05-15

3135 scDenorm: a denormalisation tool for integrating single-cell transcriptomics data

Huang, Y.; Pournara, A. V.; Ao, Y.; Yang, L.; Zhang, H.; Zhang, Y.; Liu, S.; Brazma, A.; Papatheodorou, I.; Yang, X.; Shi, M.; Miao, Z.

10.1101/2025.05.10.653289 — bioinformatics — Posted on 2025-05-15

3136 High-temporal-resolution point-of-care multiplex biomarker monitoring in small animals using microfluidic digital ELISA

Song, Y.; Stephens, A. D.; Deng, H.; Fueredi, A. D.; Su, S. H.; Ye, Y.; Chen, Y.; Newstead, M. W.; Yin, Q.; Lehto, J.; Fahim, Z.; Singer, B. H.; Kurabayashi, K.

10.1101/2025.05.11.653356 — bioengineering — Posted on 2025-05-15

3137 Two-Dimensional Nonlinear Structured Illumination Microscopy with rsEGFP2

Li, S.; Tamura, R.; Banzai, K.; Kamiyama, D.; Kner, P.

10.1101/2025.05.11.653285 — bioengineering — Posted on 2025-05-15

3138 Switching ON Hydrogen Sulfide: A Chemogenetic Toolkit for Spatially Resolved H2S Manipulation

Ghaffari Zaki, A.; Miri, S. M.; Vatandaslar, E.; Vilain, S.; Yigit, E. N.; Aydin, M. S.; Alp, M. I.; Eroglu, E.

10.1101/2025.05.12.653628 — biochemistry — Posted on 2025-05-15

3139 Discovery of late intermediates in methylenomycin biosynthesis active against drug-resistant Gram-positive bacterial pathogens

Corre, C.; Idowu, G.; Song, L.; Whitehead, M.; Alkhalaf, L.; Challis, G.

10.1101/2025.05.11.653355 — biochemistry — Posted on 2025-05-15

3140 SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

Mashiko, D.; Tonai, S.; Miyata, H.; Matzuk, M.; Ikawa, M.

10.1101/2025.05.12.653469 — developmental biology — Posted on 2025-05-15

3141 Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics

Laboy, R.; Ndoci, M.; Tabrez, S. S.; Vonolfen, M.; Ballhysa, E.; Droth, T.; Schilling, K.; Loehrke, A.; Atanassov, I.; Antebi, A.

10.1101/2023.06.14.544948 — cell biology — Posted on 2025-05-15

3142 Advanced eTAM-seq enables high-fidelity, low-input N6-methyladenosine profiling in human cells and embryonic mouse tissues

He, E. M.; Wu, Y.; Ye, C.; Zeng, T.-B.; He, C.; Tang, W.

10.1101/2025.05.11.653357 — molecular biology — Posted on 2025-05-15

3143 Injectable Immune-Engineered Hydrogel Niche Remote From The Immune Suppressed Tumor Microenvironment For Cancer Immunotherapy

Muhammad, S. N.; Zakariya, Z. T.; Shaji, S.; Sunilkumar, A. K.; George, A.; Radhakrishnan, S. P.; Nair, S. V.; Koyakutty, M.

10.1101/2025.05.11.653292 — immunology — Posted on 2025-05-15

3144 Cryo-EM evidence for a common factor in Alzheimer's and other neurodegenerations

Bridges, L. R.

10.1101/2025.05.13.653829 — neuroscience — Posted on 2025-05-15

3145 Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease

Sakai, S.; Otani, K.; Tsuyama, J.; Hara, Y.; Abe, K.; Shimamura, T.; Kawakami, I.; Komori, T.; Kawaji, H.; Hase, K.; Saito, T.; Shichita, T.

10.1101/2025.05.12.653388 — neuroscience — Posted on 2025-05-15

3146 Influence of neck tissue conductivities on the phrenic nerve activation threshold during non-invasive electrical stimulation

Wegert, L.; Di Rienzo, L.; Codecasa, L.; Ziolkowski, M.; Hunold, A.; Kalla, T.; Lange, I.; Haueisen, J.

10.1101/2025.05.12.653397 — neuroscience — Posted on 2025-05-15

3147 SARM1 is an essential component of neuronal Parthanatos

Wu, T.; Yuan, L.; Sasaki, Y.; Buchser, W.; Bloom, J.; DiAntonio, A.; Milbrandt, J.

10.1101/2025.05.14.654090 — neuroscience — Posted on 2025-05-15

3148 Transcriptomic analysis reveals new reparative mechanisms of SCF and GCSF - reduced neuropathology in aged APPPS1 mice

Addo, A.; Li, B.; Murikinati, S.; Gardner, R.; Zhao, L.-R.

10.1101/2025.05.10.653288 — neuroscience — Posted on 2025-05-15

3149 Biomimetic self-regulation in intrinsically motivated robots

Guerrero Rosado, O.; Fernandez Amil, A.; Tito Freire, I.; Vinck, M.; F.M.J. Verschure, P.

10.1101/2025.05.11.653305 — neuroscience — Posted on 2025-05-15

3150 Adolescent Peer Victimization Through a Trauma Lens: Heightened Startle Response, Increased Pupil Dilation, Elevated Cortisol, and Reduced Heart Rate Variability in Young Adulthood

Heumann, J.; Quednow, B. B.; Chumbley, J.; Eisner, M.; Ribeaud, D.; Shanahan, L.; Shanahan, M. J.

10.1101/2025.05.11.652731 — physiology — Posted on 2025-05-15

3151 Mathematical Modeling of Cancer Cell Invasion of Tissue: Development of an in silico Organotypic Assay

Andasari, V.; Gerisch, A.; South, A.; Chaplain, M. A.

10.1101/2025.05.12.653391 — biophysics — Posted on 2025-05-15

3152 Conformational Dynamics in Insulin Receptor Kinase Reveals a Type III Allosteric Pocket

Verma, J.; Vashisth, H.

10.1101/2025.05.10.653287 — biophysics — Posted on 2025-05-15

3153 A novel FRET-force biosensor for nucleoporin gp210 reveals that the nuclear pore complex experiences mechanical tension

Wang, P.; Denis, K.; Luxton, G. G.; Conway, D. E.

10.1101/2025.05.14.654032 — biophysics — Posted on 2025-05-15

3154 MedSAGE: Bridging Generative AI and Medicinal Chemistry for Structure-Based Design of Small Molecule Drugs

Powers, A. S.; Lu, T.; Koodli, R. V.; Xu, M.; Gu, S.; Karelina, M.; Dror, R. O.

10.1101/2025.05.10.653107 — biophysics — Posted on 2025-05-15

3155 MADRe: Strain-Level Metagenomic Classification Through Assembly-Driven Database Reduction

Lipovac, J.; Sikic, M.; Vicedomini, R.; Krizanovic, K.

10.1101/2025.05.12.653324 — bioinformatics — Posted on 2025-05-15

3156 Adapting ProteinMPNN for antibody design without retraining

del Alamo, D.; Frick, R.; Truan, D.; Karpiak, J. D.

10.1101/2025.05.09.653228 — bioengineering — Posted on 2025-05-15

3157 The Effects of Alginate Oligosaccharides (AOS) with Degree of Polymerization (DP) 2, 3, 4, 5, 6, and 7 on Tomato Yields

Chi, Y.; Wang, X.; Zhang, Z.

10.1101/2025.05.11.653359 — bioengineering — Posted on 2025-05-15

3158 Identifying myocardial regions perfused by coronary arteriesthrough detailed human microvasculature data

Montino Pelagi, G.; Mackenzie, J. A.; van Bavel, E. A.; Valbusa, G.; Vergara, C.; Hill, N. A.

10.1101/2025.05.12.653398 — bioengineering — Posted on 2025-05-15

3159 A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Lacoursiere, R. E.; Upadhyaya, K.; Kaur Sidhu, J.; Bejan, D. S.; Rodriguez Siordia, I.; Cohen, M. S.; Pruneda, J. N.

10.1101/2025.05.11.653360 — biochemistry — Posted on 2025-05-15

3160 Temporary parasitic ants modify nestmate discrimination patterns of host workers

Kobayashi, R.; Okada, Y.; Akino, T.; Idogawa, N.

10.1101/2025.05.10.653236 — animal behavior and cognition — Posted on 2025-05-15

3161 Age-trajectory of mother-infant relationships in wild Assamese macaques

Arbaiza-Bayona, A. L.; Mundry, R.; Malaivijitnond, S.; Meesawat, S.; Schulke, O.; Ostner, J.

10.1101/2025.05.10.653242 — animal behavior and cognition — Posted on 2025-05-15

3162 Does MHC-IIB dissimilarity between partners drive mate choice and divorce in a genetically monogamous seabird?

Thel, L.; Pineaux, M.; Ribeiro, L.; Danchin, E.; Whelan, S.; Hatch, S. A.; Blanchard, P.; Leclaire, S.

10.1101/2024.12.19.629314 — animal behavior and cognition — Posted on 2025-05-15

3163 Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging

Lu, Z.; Zhang, Z.; Xu, Z.; Abdulraouf, A.; Zhou, W.; Cao, J.

10.1101/2025.05.12.653376 — genomics — Posted on 2025-05-15

3164 UV laser crosslinking uncovers novel DNA-binding pattern of CTCF

Stanko, C.; Oezcan, S. G.; Stengel, S.; Szymanski, L.; Steube, A.; Fischer, M.; Brioli, A.; Schenk, T.

10.1101/2025.05.12.653382 — genomics — Posted on 2025-05-15

3165 Intra-Strain Genetic Heterogeneity in Toxoplasma gondii ME49: Oxford Nanopore Long-Read Sequencing Reveals Copy Number Variation in the ROP8-ROP2A Locus

Gohar, Y.; Neumann, M.; Huelse, L.; Wind, D.; Mock, J.; Buchholz, K.; Helle, M.; Sorg, U. R.; Degrandi, D.; Pfeffer, K.; Dilthey, A. T.

10.1101/2025.05.10.653050 — genomics — Posted on 2025-05-15

3166 Mapping the transcriptional regulatory network of a fungal pathogen by exploiting transcription factor perturbation

Abid, D.; Brown, H. L.; Mateusiak, C.; Doering, T. L.; Brent, M. R.

10.1101/2025.05.10.653149 — genomics — Posted on 2025-05-15

3167 Development and application of a genotyping by target sequencing SNP array panel in Salix suchowensis

Han, Y.; Gu, S.; Zhu, M.; Liu, W.; Feng, L.; Yin, T.; Gao, X.; Zan, Y.; Ji, Y.; Liu, J.

10.1101/2025.05.12.653369 — genetics — Posted on 2025-05-15

3168 Advancing global DNA-referencing of bushmeat in African tropical forests: a tool for identifying trade hotspots and dynamics in western and central Africa

Pires, D.; Gomes, C.; Groom, B.; Dufour, S.; Danquah, E.; Van Vliet, N.; Ayecaba, G. N.; Missoup, A. D.; Afiademanyo, K.; Djagoun, C. S.; Gonedele, S. B.; Chaber, A.-L.; Olayemi, A.; Antunes, A.; Gaubert, P.

10.1101/2025.05.12.653485 — genetics — Posted on 2025-05-15

3169 Phylogenetic relationships of ATM polymorphic loci haplotypes in Eurasian and African populations

Olkova, M.; Koshel, S.; Ponomarev, G.; Alimov, A.

10.1101/2025.05.10.652950 — evolutionary biology — Posted on 2025-05-15

3170 An early evolutionary stage of mutualistic endosymbiosis reveals a parasitic aspect of endosymbionts

Kamal, M. M.; Cheng, Y.-H.; Chu, L.-W.; Nguyen, P. T.; Jeff Liu, C.-F.; Liao, C.-W.; Posch, T.; Leu, J.-Y.

10.1101/2025.05.12.653378 — evolutionary biology — Posted on 2025-05-15

3171 Host niche breadth differentially modulates the effects of anthropogenic disturbance across generalist and specialist parasites

Warudkar, A.; R, G.; Arvind, C.; Ishtiaq, F.; Dharmarajan, G.; Robin, V. V.

10.1101/2025.05.11.653240 — ecology — Posted on 2025-05-15

3172 Spatial close-kin mark-recapture methods to estimate dispersal parameters and barrier strength for mosquitoes

Marshall, J. M.; Yang, S.; Bennett, J. B.; Filipovic, I.; Rasic, G.

10.1101/2025.05.11.653364 — ecology — Posted on 2025-05-15

3173 Application of post glycosylation modifying enzymes for mass spectrometry imaging of modified N-glycans in situ.

Dreifus, J. E.; Chuzel, L.; Escobar, E. E.; Grimsley, G.; Bai, H.; Hanneman, A. J.; Fossa, S. L.; Gregory, V.; Martin, R. J.; Drake, R. R.; Foster, J.; Taron, C. H.

10.1101/2025.05.14.654078 — molecular biology — Posted on 2025-05-15

3174 FIRST REPORT OF CANDIDA AURIS IN VIETNAM.

Truong-Thien, P.; Nguyen Tuan, A.; Si, T. N.

10.1101/2025.05.12.653631 — microbiology — Posted on 2025-05-15

3175 Functional Characterization of Paillotin: An Immune Peptide Regulated by the Imd Pathway with Pathogen-Specific Roles in Drosophila Immunity

Tian, Y.; Yue, X.; Jiao, R.; Hanson, M. A.; Lemaitre, B.

10.1101/2025.05.12.653313 — immunology — Posted on 2025-05-15

3176 Coherent thalamic inputs organize head direction signal in the medial entorhinal cortex

Vite, G. R.; Ding, M.; Peyrache, A.

10.1101/2025.05.14.654107 — neuroscience — Posted on 2025-05-15

3177 Disrupted salience network dynamics during the imagery of migraine attacks

Esteves, I.; Perdigao, A.; Fouto, A. R.; Ruiz-Tagle, A.; Caetano, G.; Cabral, J.; Martins, I. P.; Gil-Gouveia, R.; Caballero-Gaudes, C.; Figueiredo, P.

10.1101/2025.05.10.653239 — neuroscience — Posted on 2025-05-15

3178 Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals: A neuromelanin-sensitive MRI study

Etani, T.; Nakajima, S.; Honda, S.; Homma, S.; Kaneko, Y.; Kondoh, S.; Tarumi, R.; Tsugawa, S.; Moriyama, S.; Tobari, Y.; Samma, T.; Horga, G.; Cassidy, C.; Uchida, H.; Fujii, S.

10.1101/2025.05.10.653047 — neuroscience — Posted on 2025-05-15

3179 Unreliable homeostatic action potential broadening in cultured dissociated neurons

Ritzau-Jost, A.; Rajayer, S.; Nerlich, J.; Maciag, F.; John, A.; Russier, M.; Gonzalez Sabater, V.; Steiger, L.; Coq, J.-O.; Eilers, J.; Engelhardt, M.; Burrone, J.; Debanne, D.; Heine, M.; Smith, S. M.; Hallermann, S.

10.1101/2025.05.09.653135 — neuroscience — Posted on 2025-05-15

3180 MAX2-dependent signaling regulates the transition from 2D to 3D growth by suppressing cytokinin accumulation in Physcomitrium patens

Luo, Y.; Hata, Y.; Ohtsuka, J.; Komatsu, A.; Kojima, M.; Sakakibara, H.; Kyozuka, J.

10.1101/2025.05.15.654175 — plant biology — Posted on 2025-05-15

3181 Physical activity promotes gut adaptation, responses to nutrients, and sensitivity to gut peptides

Baech-Laursen, C.; Vergara Ucin, J.; Galsgaard, K. D.; Llana, J.; Kissow, H.; Holst, J. J.; Pedersen, B. K.; Sanchis, P.

10.1101/2025.05.12.653520 — physiology — Posted on 2025-05-15

3182 Pericytes in heart

ZHAO, G.; Lederer, W. J.

10.1101/2025.05.14.654087 — physiology — Posted on 2025-05-15

3183 The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock

Sedore, C. A.; Segerdell, E.; Coleman-Hulbert, A. L.; Johnson, E.; Levi, J. N.; Lithgow, G. J.; Driscoll, M.; Phillips, P. C.

10.1101/2025.05.11.653363 — physiology — Posted on 2025-05-15

3184 The Dynamics of Inducible Genetic Circuits

Yang, Z.; Rousseau, R. J.; Mahdavi, S. D.; Garcia, H. G.; Phillips, R.

10.1101/2025.05.11.653320 — biophysics — Posted on 2025-05-15

3185 Sewing the future of cotton: a multi-omics study combining nanomechanics, transcriptomics, and phenotypic traits

Hasib, M. H. H.; Masud, N.; Biswas, A.; Jubery, T. Z.; Stanley, C.; Swaminathan, S.; Grover, C. E.; Wendel, J. F.; Sarkar, S.; Zabotina, O. A.; Sarkar, A.

10.1101/2025.05.12.653486 — biophysics — Posted on 2025-05-15

3186 Flexible fitting to infer atomistic-precision models of large-amplitude conformational dynamics in biomolecules from high-speed atomic force microscopy imaging

Amyot, R.; Miyashita, O.; Wu, X.; Takeda, K.; Kodera, N.; Konno, H.; Tama, F.; Flechsig, H.

10.1101/2025.05.14.653975 — biophysics — Posted on 2025-05-15

3187 TRPM8 protein dynamics correlates with ligand structure and cellular function

Mebrat, M. D.; Luu, D. D.; Hilton, J. K.; Kim, M.; Parrott, K.; Cherry, B. R.; Levitus, M.; Journigan, V. B.; Van Horn, W. D.

10.1101/2025.05.13.653789 — biophysics — Posted on 2025-05-15

3188 The Kink-Turn Motif: A Powerful Test for Revealing Weaknesses in RNA Force Fields

Lemmens, T.; Mlynsky, V.; Sponer, J.; Pykal, M.; Banas, P.; Otyepka, M.; Krepl, M.

10.1101/2025.05.13.653794 — biophysics — Posted on 2025-05-15

3189 High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface Antigens

Kothiwal, D.; Kollasch, A. W.; Hollmer, N.; Ghosh, A.; Zhang, R.; Anuganti, M.; Paul, S. B.; Zagar, Y.; Abdollahi, M.; Anderson, Z.; Belay, F.; Salotto, M.; Ulmer, S.; AbdelAlim, Y. A.; Kumar, S.; Vangala, M.; Yang, C.; Chedotal, A.; Jardine, J. G.; Teixeira, A. A. R.; Moshinsky, D. J.; Zhu, H.; Zhu, S.; Springer, T. A.; Marks, D. S.; Meijers, R.

10.1101/2025.05.15.650607 — biophysics — Posted on 2025-05-15

3190 Extracellular Matrix Physical Properties Regulate Cancer Cell Morphological Transitions in 3D Hydrogel Microtissues

Pourmostafa, A.; Uskach, G.; Jafari, M.; Yogeshwaran, S.; Wood, T. L.; Alisafaei, F.; Miri, A. K.

10.1101/2025.05.10.653220 — biophysics — Posted on 2025-05-15

3191 Functional targeting of Glypican-4 by a conformation-specific single-domain antibody

BONJEAN, R.; KERFELECK, B.; CHAMES, P.; DONO, R.

10.1101/2025.05.10.653258 — bioengineering — Posted on 2025-05-15

3192 Molecular Insights into Methyllysine Recognition by the Methyl-CpG-Binding Domain of MeCP2

Padhan, J.; Sudhamalla, B.

10.1101/2025.05.10.653294 — biochemistry — Posted on 2025-05-15

3193 ERGA-BGE genome of Coenonympha oedippus: an IUCN endangered European butterfly species occurring in two ecotypes

Celik, T.; Lokovsek, T.; Buzan, E.; Boehne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Gut, M.; Aguilera, L.; Camara Ferreira, F.; Cruz Rodriguez, F.; Gomez-Garrido, J.; Alioto, T. S.; Haggerty, L.; Martin, F.; Bortoluzzi, C.

10.1101/2025.02.10.637396 — genomics — Posted on 2025-05-15

3194 ERGA-BGE genome of Cheirolophus tagananensis: an IUCN endangered shrub endemic to the Canary Islands

Pellicer, J.; Garnatje, T.; Vitales, D.; Hidalgo, O.; Valles, J.; Garcia-Fernandez, A.; Santos-Guerra, A.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory Team, ; Wellcome Sanger Institute Scientific Operations: Sequencing Operations, ; Wellcome Sanger Institute Tree of Life Core Informatics Team, ; Thomas, A.; Jackson, B.; Wood, J. M.; Howe, K.; Blaxter, M.; McCarthy, S.; Enriquez, V. P. B.; Haggerty, L.; Martin, F.; Bortoluzzi, C.

10.1101/2025.01.24.634661 — genomics — Posted on 2025-05-15

3195 Sex differences in DNA methylation in bats

Rayner, J. G.; Bock, S. L.; Lonski, A. J.; Riddle, N. C.; Wilkinson, G. S.

10.1101/2025.05.13.653776 — evolutionary biology — Posted on 2025-05-15

3196 Questioning the Evidence for Host-Symbiont Codiversification in Mycorrhizal Symbioses

Bodin, F.; Morlon, H.; Perez-Lamarque, B.

10.1101/2025.05.14.653600 — evolutionary biology — Posted on 2025-05-15

3197 Spatiotemporal diversification of forest understorey species reveals the existence of multiple Pleistocene forest refugia in Central Europe

Voisin, C.; Kirschner, P.; Zaveska, E.; Frajman, B.; Huelber, K.; Wessely, J.; Willner, W.; Schoenswetter, P.; Carnicero, P.

10.1101/2025.05.13.653645 — evolutionary biology — Posted on 2025-05-15

3198 The role of cytonuclear interactions to plant adaptation across a Populus hybrid zone

Zavala-Paez, M.; Sutara, B.; Keller, S.; Holliday, J.; Fitzpatrick, M.; Hamilton, J.

10.1101/2025.05.13.653687 — evolutionary biology — Posted on 2025-05-15

3199 Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids

Suzuki, H. C.; Saito, C. T.; Rajshekar, S.; Sokabe, T.; Haji, D.; Groen, S. C.; Pelaez, J. N.; Matsunaga, T.; Takemoto, A. S.; Tanaka, K. M.; Takahashi, A.; Tominaga, M.; Saito, S.; Whiteman, N. K.

10.1101/2025.05.09.653172 — evolutionary biology — Posted on 2025-05-15

3200 Advancing the design of the kissing bug kill trap for surveillance of triatomines

Tian, Y.; Fernandez-Santos, N. A.; Juarez, J. G.; Esquivel, H.; Moller-Vasquez, A. M.; Granados-Presa, M.; Echeverria, A.; Pennington, P. M.; Fimbres-Macias, J. P.; Roachell, W.; Lenhart, P.; Casey, T.; Keck, M. E.; Hodo, C. L.; Downs, C. H.; Sittenauer, S. C.; Nevins, C.; Balasubramanian, S.; Angulo, C.; Palacios-Cardiel, C.; Gaxiola-Robles, R.; Zenteno-Savin, T.; Hamer, S. A.; Borden, J. H.; Banfield, M. G.; Padilla, N.; Hamer, G. L.

10.1101/2025.05.09.653139 — ecology — Posted on 2025-05-15

3201 Neural stem cell quiescence is actively maintained by the epigenome

Malkowska, A.; Ander, J.; Brand, A. H.

10.1101/2025.05.14.653490 — developmental biology — Posted on 2025-05-15

3202 Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production

Bekendam, R. H.; Camacho, V.; Stone, A. P.; Barrachina, M. N.; Branfield, S.; Carminita, E.; Becker, I. C.; Lee, D. H.; Walsey, E.; Kaplan, J.; Payne, C.; Tilburg, J.; Pal, S.; Batista, L. F. Z.; Italiano, J. E.; Machlus, K. R.

10.1101/2025.05.08.652525 — cell biology — Posted on 2025-05-15

3203 Rainbow Nucleus Charts Dynamic Interactome of Membrane-less Organelles

Ye, S.; Benhamou Goldfajn, N.; So, C. L.; Inoue, T.; Cai, D.

10.1101/2025.05.14.654140 — cell biology — Posted on 2025-05-15

3204 Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood

Khateb, M.; Jung, R.; Leibou, S.; Hadley, P.; Yu, Z.; Dinerman, A. J.; Dulemba, V.; Gasmi, B.; Levin, N.; Kim, P.; Bhasin, A.; Bhat, D.; Sindiri, S.; Gartner, J. J.; Prickett, T. D.; Benzine, T.; Farid, S. S.; Parkhurst, M. R.; Halas, H.; Cao, Y.; Zhao, K.; Yang, J. C.; Robbins, P. F.; Lowery, F.; Krishna, S.; Heller, T.; McVicar, D.; Rosenberg, S. A.; Klemen, N. D.

10.1101/2025.05.11.653315 — immunology — Posted on 2025-05-15

3205 Interoceptive Accuracy Modulates Electroencephalogram During Music Recall Tasks

Matsunaga, K.; Chanpornpakdi, I.; Tanaka, T.

10.1101/2025.05.09.652994 — neuroscience — Posted on 2025-05-15

3206 D-amphetamine alters the dynamic ECoG activity distribution patterns in the rat neocortex

Mellbin, A.; Jörntell, H.; Bengtsson, F.

10.1101/2025.05.09.653067 — neuroscience — Posted on 2025-05-15

3207 Human gloss perception reproduced by tiny neural networks

Morimoto, T.; Akbarinia, A.; Storrs, K. R.; Cheeseman, J. R.; Smithson, H. E.; Gegenfurtner, K. R.; Fleming, R. W.

10.1101/2025.05.09.653112 — neuroscience — Posted on 2025-05-15

3208 Large Language Models Reveal the Neural Tracking of Linguistic Context in Attended and Unattended Multi-Talker Speech

Puffay, C.; Mischler, G.; Choudhari, V.; Vanthornhout, J.; Bickel, S.; Mehta, A. D.; Schevon, C. A.; McKhann, G. M.; Van hamme, H.; Francart, T.; Mesgarani, N.

10.1101/2025.04.24.648897 — neuroscience — Posted on 2025-05-15

3209 MINN: A METABOLIC-INFORMED NEURAL NETWORK FOR INTEGRATING OMICS DATA INTO GENOME-SCALE METABOLIC MODELING

Tazza, G.; Moro, F.; Ruggeri, D.; Teusink, B.; Vidacs, L.

10.1101/2025.05.14.653943 — systems biology — Posted on 2025-05-15

3210 Conserved spatial patterning of gene expression in independent lineages of C4 plants

Sun, T.; Bonthala, V. S.; Stich, B.; Luginbuehl, L. H.; Hibberd, J. M.

10.1101/2025.05.14.654047 — plant biology — Posted on 2025-05-15

3211 Integration of diploid T2T parental genomes with progeny genomes and transcriptomes identifies resistance genes in the grape powdery mildew resistance loci Ren6 and Ren7 of Vitis piazeskii

Massonnet, M.; Figueroa-Balderas, R.; Cochetel, N.; Riaz, S.; Pap, D.; Walker, M. A.; Cantu, D.

10.1101/2025.05.14.653892 — plant biology — Posted on 2025-05-15

3212 Fungal susceptibility and early flowering in pennycress (Thlaspi arvense) are conferred by naturally occurring mutations in histone demethylase Jumonji 14

Codjoe, J. M.; Kujur, A.; Sirasani, J. P.; Shamin, A.; Sauer, T.; Rai, K.; Ulmasov, T.; Chopra, R.; Shah, D. M.

10.1101/2025.05.14.654108 — plant biology — Posted on 2025-05-15

3213 Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach

Schwartz, S.; Engstler, C.; Muehlbauer, S.; Windenbach, E.; Wunder, T.; Kunz, H.-H.; Brandt, B.

10.1101/2025.05.15.654187 — plant biology — Posted on 2025-05-15

3214 Arabidopsis thaliana Phytochrome A Sensory Properties in Canopy Shade

Butlin, P.; Valdivia-Cabrera, M.; Grima, R.; Halliday, K.

10.1101/2025.05.14.654025 — plant biology — Posted on 2025-05-15

3215 Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product

Jagannathan, N. S.; Sin, W.-X.; Teo, D. B. L.; Kairi, F.; Luah, Y. H.; Lim, F. L. W. I.; Seng, M. S.-F.; Soh, S. Y.; Lee, Y. H.; Tucker-Kellogg, L.; Birnbaum, M. E.; Ram, R. J.

10.1101/2025.05.11.653250 — cancer biology — Posted on 2025-05-15

3216 Carbon-phosphorous exchange rate constrains growth of arbuscular mycorrhizal fungal networks

Bisot, C.; Galvez, L. O.; Kahane, F.; van Son, M.; Turcu, B.; Broekman, R.; Lin, K.-K.; Botenbal, P.; Winter, M. K.; Kokkoris, V.; West, S. A.; Godin, C.; Kiers, E. T.; Shimizu, T. S.

10.1101/2025.05.12.653230 — biophysics — Posted on 2025-05-15

3217 Controlling the morphologies and dynamics in three-dimensional tissues

Das, R.; Li, X.; Sinha, S.; Thirumalai, D.

10.1101/2025.05.09.653101 — biophysics — Posted on 2025-05-15

3218 Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors

Merz, M. L.; Kailass, K.; Pergu, R.; Tran, K.; Gupta, K.; Severance, Z. C.; Singh, S.; Vedagopuram, S.; Law, B. K.; Rosenblatt, G.; Dhaliwal, R.; Choudhary, A.

10.1101/2025.05.10.652755 — biochemistry — Posted on 2025-05-15

3219 Phosphorylation-inducing molecules for regulating dynamic cellular processes

Pergu, R.; Vedagopuram, S.; Kokkonda, P.; Lai, S.; Tiwari, P. K.; Singh, S.; Kawai, J.; Singha, S.; Tian, W.; Thimaradka, V.; Tran, K.; Choudhary, A.

10.1101/2025.05.10.652895 — biochemistry — Posted on 2025-05-15

3220 Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration

Chen, C.; Gao, T.-Y.; Yi, H.-W.; Zhang, Y.; Wang, T.; Lou, Z.-L.; Wei, T.-F.; Lu, Y.-B.; Li, T.; Tang, C.; Zhang, W.-P.

10.1101/2024.10.18.619025 — biochemistry — Posted on 2025-05-15

3221 ERGA-BGE genome of Noah's Ark shell (Arca noae Linnaeus, 1758), a Mediterranean bivalve species

Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Sequencing Team, G.; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Teodori, E.; Duprat, S.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Haggerty, L.; Martin, F.; Bortoluzzi, C.

10.1101/2025.02.10.632159 — genomics — Posted on 2025-05-15

3222 A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)

Bikas, D. V.; Vardabasso, S.; Quickstad, G.; Shpargel, K. B.

10.1101/2025.05.15.654100 — developmental biology — Posted on 2025-05-15

3223 CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology

Kang, B.; Murphy, M.; Ng, C. W.; Leventhal, M. J.; Huynh, N.; Im, E.; Danquah, S.; Housman, D. E.; Nehme, R.; Farhi, S. L.; Fraenkel, E.

10.1101/2025.02.19.639023 — neuroscience — Posted on 2025-05-15

3224 Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease (V2)

Chocarro, J.; Marana, S.; Espelosin, M.; Rico, A. J.; Ariznabarreta, G.; Lorenzo-Ramos, E.; Ilarduya, M. M.; Hernandez-Alcoceba, R.; Chillon, M.; Vila, M.; Kordower, J.; Schapira, A. H. V.; Garcia-Osta, A.; Cuadrado-Tejedor, M.; Lanciego, J. L.

10.1101/2025.05.09.653000 — neuroscience — Posted on 2025-05-15

3225 Harnessing machine learning models for epigenome to transcriptome association studies

Behjati ardakani, F.; Ashrafiyan, S.; Rumpf, L.; Hecker, D.; Schulz, M. H.

10.1101/2025.05.09.653095 — bioinformatics — Posted on 2025-05-15

3226 Alginate-ϵPLL core-shell hydrogel beads as a tool for an effective, stable and scalable microbial encapsulation

Amaro-Cruz, A.; Garcia-Roman, M.; Moya-Ramirez, I.

10.1101/2025.01.17.633598 — bioengineering — Posted on 2025-05-15

3227 Ancient DNA reveals diverse community organizations in the 5th millennium BCE Carpathian Basin

Szecsenyi-Nagy, A.; Virag, C.; Jakab, K.; Rohland, N.; Ringbauer, H.; Anders, A.; Raczky, P.; Hajdu, T.; Kiss, K.; Szeniczey, T.; Evinger, S.; Keszi, T.; Virag, Z. M.; Cheronet, O.; Mallick, S.; Akbari, A.; Pinhasi, R.; Reich, D.; Siklosi, Z.; Szecsenyi-Nagy, A.

10.1101/2025.01.02.631136 — genomics — Posted on 2025-05-15

3228 Pangenome analysis provides insights into the evolution of mango (Mangifera spp.)

Li, J.; Michael, V. N.; Simpson, S. A.; Youngblood, R. C.; Scheffler, B. E.; Crane, J. H.; Chen, S.; Hulse-Kemp, A. M.; Wu, X.

10.1101/2025.05.09.653124 — genomics — Posted on 2025-05-15

3229 decemedip: hierarchical Bayesian modeling for cell type deconvolution of immunoprecipitation-based DNA methylomes

Shen, N.; Zhang, Z.; Baca, S.; Korthauer, K.

10.1101/2025.05.09.653152 — genomics — Posted on 2025-05-15

3230 Conservative evolution of genetic and genomic features in Caenorhabditis becei, an experimentally tractable gonochoristic worm

Salome-Correa, J. A.; Noble, L. M.; Sloat, S. A.; Nguyen, T. H. M.; Rockman, M. V.

10.1101/2025.05.09.653148 — evolutionary biology — Posted on 2025-05-15

3231 Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila

Hofe, P.; Gardner, T.; DiNardo, S.; Anllo, L.

10.1101/2025.05.09.653127 — developmental biology — Posted on 2025-05-15

3232 Loss of starvation-and-light sporulation trigger in Myxomycetes Physarum roseum

Masui, M.; Phillip, Y. K.; Kono, N.

10.1101/2025.05.10.652879 — molecular biology — Posted on 2025-05-15

3233 Cryptococcus displays spore-specific invasion of alveolar epithelial cells

Ortiz, S. C.; Fortune-Grant, R.; Thom, A. J.; Davies, J.; May, R. C.; Drummond, R. A.; Bertuzzi, M.

10.1101/2023.12.14.571430 — microbiology — Posted on 2025-05-15

3234 Glycolysis-dependent Sulfur Metabolism Orchestrates Morphological Plasticity and Virulence in Fungi

Shah, D.; M, A.; Rewatkar, N.; Gupta, S.; Mathivathanan, S.; Varahan, S.

10.1101/2025.05.14.654021 — microbiology — Posted on 2025-05-15

3235 Unveiling potato cultivars with microbiome interactive traits for sustainable agricultural production

Zhao, T.; Vink, S. N.; Jia, X.; Erban, A.; Schaarschmidt, S.; Kopka, J.; Zuther, E.; Treder, K.; Michalowska, D.; Guyoneaud, R.; Elzenga, J. T. M.; Attard, E.; Falcao Salles, J.

10.1101/2024.08.21.609084 — microbiology — Posted on 2025-05-15

3236 Affinity-matured CD72-targeting Nanobody CAR T-cells Enhance Elimination of Antigen-Low B-cell Malignancies

Izgutdina, A.; Rashid, T.; Temple, W. C.; Patino-Escobar, B.; Walunj, S.; Geng, H.; Takamatsu, H.; Gil-Alos, D.; Kang, A. S.; Ramos, E.; Chen, S.-Y.; Johnson, H.; Nix, M. A.; Naik, A.; Yuan, C. M.; Wang, H.-W.; Aminov, S.; Sahu, S.; Larson, R. C.; Carpenter, C.; Salangsang, F.; Phojanakong, P.; Camara Serrano, J. A.; Tariq, I.; Zakraoui, O.; Steri, V.; Valeri, A.; Martinez-Lopez, J.; Maus, M. V.; Parekh, S.; Verma, A.; Shah, N. N.; Wiita, A.

10.1101/2025.05.09.653155 — immunology — Posted on 2025-05-15

3237 Newly discovered and conserved role of IgM against viral infection in an early vertebrate

Kong, W.; Wang, X.; Ding, G.; Yang, P.; Shi, Y.; Cai, C.; Yang, X.; Cheng, G.; Takizawa, F.; XU, Z.

10.1101/2024.11.11.622905 — immunology — Posted on 2025-05-15

3238 Neural Population Mechanisms for Flexible Sensorimotor Control

Kalidindi, H. T.; Crevecoeur, F.

10.1101/2025.05.15.654192 — neuroscience — Posted on 2025-05-15

3239 Respiratory vocal coordination increases as zebra finches prepare to sing

Kizhakoot, D. B.; Kalra, S.; PR, R.; Chorol, S.; Chitnis, S.; Rao, D.; Rajan, R.

10.1101/2025.05.14.654126 — neuroscience — Posted on 2025-05-15

3240 Expectation management in humans and LLMs

Menashe, B.; Drake, A.; Ben-Shachar, M.

10.1101/2025.03.09.642185 — neuroscience — Posted on 2025-05-15

3241 No Effect of Chronic or Acute Pain on Working Memory in the Sternberg Task

Phelps, C. E.; Oliveira, L. E.; Ngo, M. N.; Medhi, K. S.; Schoone, S.; Debrosse, D.; Aragundi, L.; Delval, A. G. R.; Wilson, R. C.

10.1101/2025.05.13.653893 — neuroscience — Posted on 2025-05-15

3242 Stochastic activity in low-rank recurrent neural networks

Mastrogiuseppe, F.; Carmona, J.; Machens, C.

10.1101/2025.04.22.649933 — neuroscience — Posted on 2025-05-15

3243 Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

Rollenhagen, A.; Sadeghi, A.; Walkenfort, B.; Hilgetag, C.; Saetzler, K.; Luebke, J. H.

10.1101/2024.06.14.599047 — neuroscience — Posted on 2025-05-15

3244 Unraveling Network Dynamics via Riemannian Multi-Scale Decomposition

Kleerekoper, Y.; Kurtam, M.; Keselman, Y.; Ghanayim, A.; Schiller, J.; Musall, S.; Sciller, Y.; Benisty, H.

10.1101/2025.03.26.645425 — neuroscience — Posted on 2025-05-15

3245 A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.

Marella, S.; Bogle, R.; Fox, J.; Tsoi, L. C.; Xing, X.; Gu, Y.; Kirma, J.; Sarkar, M. K.; van Drongelen, V.; Klein, B.; Kozlow, J. H.; Harms, P.; Gallagher, K.; Naik, S.; Rebecca, V. W.; Andersen, B.; Nakamura, M.; Kahlenberg, J. M.; Modlin, R. L.; Billi, A. C.; Gudjonsson, J. E.

10.1101/2025.05.10.653184 — systems biology — Posted on 2025-05-15

3246 Targeting AML Resistance with Two Novel Combinations Demonstrate Superior Efficacy in TP53, HLA-B, MUC4 and FLT3 mutations

Gholizadeh, E.; Zangene, E.; Parsons, A.; Kontro, M.; Heckman, C. A.; Jafari, M.

10.1101/2024.12.31.630711 — cancer biology — Posted on 2025-05-15

3247 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Li, Y.; Zhang, X.

10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-05-15

3248 Mechanistic Insights into the Plasmodium Phosphatase UIS2 in eIF2α Dephosphorylation via Integrated Structure-Based Modeling

Wu, S.; Wagner, G.

10.1101/2025.05.14.654012 — biophysics — Posted on 2025-05-15

3249 Nonspecific interactions can lead to liquid-liquid phase separation in coiled-coil proteins models

Ramirez, D. A.; Shrimpton, A.; Shirts, M. R.; Hough, L. E.

10.1101/2025.05.09.653163 — biophysics — Posted on 2025-05-15

3250 A genome-wide, machine learning-guided exploration of the cis-regulatory code involved in neuronal differentiation

Cassan, O.; Raynal, J.; Vroland, C.; Yasuzawa, K.; Kouno, T.; Chang, J.-C.; Hon, C.-C.; Shin, J. W.; Kato, M.; Takahashi, H.; Kasukawa, T.; Nobusada, T.; Lagani, V.; Lehmann, R.; Yauy, K.; Carninci, P.; Yip, C. W.; Brehelin, L.; Lecellier, C. H.

10.1101/2025.05.14.653995 — bioinformatics — Posted on 2025-05-15

3251 FERMO: a Dashboard for Automated Prioritization of Molecular Features from Mass Spectral Data

Zdouc, M. M.; Augustijn, H. E.; Machushynets, N. V.; Bayona, L. M.; Soldatou, S.; de Jonge, N. F.; Casu, S.; Jaspars, M.; van Wezel, G. P.; Medema, M. H.; van der Hooft, J. J. J.

10.1101/2022.12.21.521422 — bioinformatics — Posted on 2025-05-15

3252 TCRanalyzer: A user-friendly tool for comprehensive analysis of T-cell diversity, dynamics and potential antigen targets

Seifert, N.; Reinke, S.; Kurz, N. S.; Demmer, J.; Kornrumpf, K.; Beissbarth, T.; Klapper, W.; Altenbuchinger, M.

10.1101/2025.05.09.652820 — bioinformatics — Posted on 2025-05-15

3253 Harmonizing single cell 3D genome data with STARK and scNucleome

Wen-Jie, J.; Kangwen, C.; Yuanchen, S.; An, L.; Hanwen, Z.; Ruixiang, G.; Chunge, Z.; Nana, W.; Futing, L.; Ten, F.; Yu-Juan, W.; Xiaoqi, Z.; Ming, X.; Hua-Jun, W.

10.1101/2025.05.10.653247 — bioinformatics — Posted on 2025-05-15

3254 A complete map of human cytosolic degrons and their relevance for disease

Voutsinos, V.; Johansson, K. E.; Larsen, F. B.; Gronbaek-Thygesen, M.; Jonsson, N.; Holm-Olesen, E.; Tesei, G.; Stein, A.; Fowler, D. M.; Lindorff-Larsen, K.; Hartmann-Petersen, R.

10.1101/2025.05.10.653233 — biochemistry — Posted on 2025-05-15

3255 Genome landscape and genetic architecture of recombination in domestic goats (Capra Hircus)

Etourneau, A.; Rupp, R.; Servin, B.

10.1101/2025.05.15.654186 — genetics — Posted on 2025-05-15

3256 Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase

Longtine, C.; Frenk, S.; Lister-Shimauchi, E. H.; Ahmed, S.

10.1101/292722 — genetics — Posted on 2025-05-15

3257 FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

Parekh, P.; Parker, N.; Pecheva, D.; Frei, E.; Vaudel, M.; Smith, D. M.; Rigby, A.; Jahołkowski, P.; Sonderby, I. E.; Birkenaes, V.; Bakken, N. R.; Fan, C. C.; Makowski, C.; Kopal, J.; Loughnan, R. J.; Hagler, D. J.; van der Meer, D.; Johansson, S.; Njolstad, P. R.; Jernigan, T. L.; Thompson, W. K.; Frei, O.; Shadrin, A. A.; Nichols, T. E.; Andreassen, O. A.; Dale, A. M.

10.1101/2025.05.09.653146 — genetics — Posted on 2025-05-15

3258 Prediction of mosquito vector abundance for three species in the Anopheles gambiae complex

Hosack, G. R.; El-Hachem, M.; Ickowicz, A.; Beeton, N. J.; Wilkins, A.; Hayes, K. R.; Rund, S. S. C.; Kelly, S. A.; McDowell, M. A.

10.1101/2025.03.04.641552 — ecology — Posted on 2025-05-15

3259 HOXA10-TWIST2 Antagonism Drives Partial Epithelial-to-Mesenchymal transition for Embryo Implantation

Ashary, N. S.; Suresh, S.; Bhide, A.; Shyamal, S.; N, P.; Mishra, A.; Patil, S.; A, A.; Hansda, S.; BV, H.; Jolly, M. K.; Modi, D.

10.1101/2025.01.10.631632 — developmental biology — Posted on 2025-05-15

3260 Cell Growth Simulator: a user-friendly web server for growth balance analysis

Ghaffarinasab, S.; Dourado, H.

10.1101/2025.05.14.653971 — cell biology — Posted on 2025-05-15

3261 An approach to differentiating biological from chemical sulfide oxidation on corroded concrete sewer surfaces

Huang, X.; Yin, Y.; Zuo, Z.; Shi, T.; Kuen, T.; Yuan, Z.; Zheng, M.

10.1101/2025.05.13.653906 — microbiology — Posted on 2025-05-15

3262 Somatosensory timing and cerebellar-basal ganglia beta-band interactions in Parkinson's disease

Pando-Naude, V.; Andersen, L.

10.1101/2025.05.15.653735 — neuroscience — Posted on 2025-05-15

3263 Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem

Ness, T. V.; Koch, C.; Einevoll, G.

10.1101/2024.08.04.603691 — neuroscience — Posted on 2025-05-15

3264 Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos

Li, X.; Huebner, R. J.; Williams, M. L. K.; Sawyer, J.; Peifer, M.; Wallingford, J. B.; Thirumalai, D.

10.1101/2024.07.11.603175 — biophysics — Posted on 2025-05-15

3265 Selective Knockout of Murine Glutamic Acid-rich Protein 2 (GARP2) Significantly Alters Cellular Dark Noise in Rod Photoreceptors

Stacks, D.; Bocchero, U.; DeRamus, M. L.; Nguyen, M.; Messinger, J.; Kraft, T. W.; Pittler, S. J.; Pahlberg, J.

10.1101/2025.05.09.653122 — neuroscience — Posted on 2025-05-14

3266 Carboxyl Terminal Domain Missense Mutations Alter Distinct Gating Properties of the Cardiac Sodium Channel

Sharma, A.; Marra, C.; Mohammad, N.; Iatckova, V.; Lawrence, L.; Goldfarb, M.

10.1101/2025.05.09.653108 — physiology — Posted on 2025-05-14

3267 Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice

Layne, J. E.; Snapper, D. M.; Czachor, M. E.; Lam, C.; Matityahu, J. D.; Lind, D. R. G.; Huard, M.; Morioka, K.; Motzkin, J. C.; Basbaum, A. I.; Weinrich, J. A. P.; Bahney, C. S.

10.1101/2025.05.09.652892 — animal behavior and cognition — Posted on 2025-05-14

3268 The landscape of fitness effects of putatively functional noncoding mutations in humans

Di, C.; Ramesh, S.; Ernst, J.; Lohmueller, K. E.

10.1101/2025.05.14.654124 — evolutionary biology — Posted on 2025-05-14

3269 Thyroid hormone promotes fetal neurogenesis

Salas-Lucia, F.; Escamilla, S.; Charest, A.; Jiang, H.; Stout, R.; Bianco, A. C.

10.1101/2025.05.14.654075 — neuroscience — Posted on 2025-05-14

3270 DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change

Pravata, M. V.; Forero, A.; Ayo Martin, A. C.; Berto, G.; Heymann, T.; Fast, L.; Mann, M.; Riesenberg, S.; Cappello, S.

10.1101/2025.05.14.654031 — neuroscience — Posted on 2025-05-14

3271 A Unique Role for the Hippocampus in Cue Integration During Human Spatial Navigation

Wei, Z.; Wolbers, T.; Chen, X.

10.1101/2025.05.14.654008 — neuroscience — Posted on 2025-05-14

3272 Quantifying cortical maturational aspects during different vigilance states in preterm infants by advanced EEG analysis

Burlando, G.; Uccella, S.; Marazzotta, V.; Wang, S. H.; Palva, J. M.; Roascio, M.; Rossi, A.; Ramenghi, L. A.; Nobili, L.; Arnulfo, G.

10.1101/2025.05.14.653972 — neuroscience — Posted on 2025-05-14

3273 Assembling unmapped reads reveals hidden variation in South Asian genomes

Das, A.; Biddanda, A.; McCoy, R. C.; Schatz, M.

10.1101/2025.05.14.653340 — genomics — Posted on 2025-05-14

3274 Phytoplankton and giant virus dynamics during different monsoon seasons, a fish kill, and a toxic bloom in a eutrophic mariculture area

Gajigan, A. P.; Apego, G. C. M. B.; Gianan, E. L. D.; Francisco, R. B.; Tai, J. J.; Benico, G. A.; Repollo, C. L. A.; Villanoy, C. L.; Yniguez, A. T.; Conaco, C.; Steward, G. F.

10.1101/2025.05.12.653504 — microbiology — Posted on 2025-05-14

3275 Habenula alterations in resting state functional connectivity among autistic individuals

Hampson, C. L.; Peraza, J. A.; Guerrero, L. M.; Bottenhorn, K. L.; Riedel, M. C.; Almuqhim, F.; Smith, D. D.; Schmarder, K. M.; Crooks, K. E.; Pintos Lobo, R.; Sutherland, M. T.; Musser, E. D.; Dai, Y.; Agarwal, R.; Saeed, F.; Laird, A. R.

10.1101/2025.05.14.653992 — neuroscience — Posted on 2025-05-14

3276 Frequency and Characterization of Rare Histologic Subtypes in Canine Invasive Urothelial Carcinoma

Corbett, M. P.; Elbadawy, M.; Woodward, A. P.; Cheville, J. C.; Wickham, H.; Nicholson, H.; Catucci, M.; Melvin, B. J.; Ahmed, B.; Zdyrski, C.; Oliveira, L. J.; Howerth, E. W.; Pawlak, A.; Fasina, O.; Mochel, J. P.; Allenspach, K.

10.1101/2025.05.13.651218 — pathology — Posted on 2025-05-14

3277 VAMP5 is a novel target for selective inhibition of gliomas with high NDRG4 expression via downregulating PLK1 and beyond

Zhang, Y.; Liu, Y.; Zhang, W.; Wang, H.; Wang, J.; Sui, Y.

10.1101/2025.05.12.653623 — cancer biology — Posted on 2025-05-14

3278 Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of chromatin arrays

Gao, J.; Li, H.; Tan, S.; Zhou, R.; Lee, T.-H.

10.1101/2025.05.09.653121 — biophysics — Posted on 2025-05-14

3279 Hemolytik2: An Updated Database of Hemolytic Peptides and Proteins

Singh, A.; S A, K. R. S. A.; Rathore, A. S.; Raghava, G. P. S.

10.1101/2025.05.12.653624 — bioinformatics — Posted on 2025-05-14

3280 VaMiAnalyzer: An open source, python-based application for analysis of 3D in vitro vasculogenic mimicry assays

Moore, S. P. G.; Zhang, X.; Jonathan, O. C.; Zou, A.; Lang, D.; Zhang, C.

10.1101/2025.05.13.653881 — bioinformatics — Posted on 2025-05-14

3281 Atlas-scale metabolic activities inferred from single-cell and spatial transcriptomics

Armingol, E.; Ashcroft, J.; Mareckova, M.; Prete, M.; Lorenzi, V.; Icoresi Mazzeo, C.; Lee, J. T. H.; Moullet, M.; Bayraktar, O. A.; Becker, C.; Zondervan, K.; Garcia-Alonso, L.; Lewis, N. E.; Vento-Tormo, R.

10.1101/2025.05.09.653038 — bioinformatics — Posted on 2025-05-14

3282 SANTON: Sequencing Analysis Toolkits for Off-target Nomination

Qiu, H.; Wang, R.; Wang, S.; Mulbagal, A. M.; Anderson, E.; Ge, H. G.

10.1101/2025.05.09.653082 — bioinformatics — Posted on 2025-05-14

3283 Establishment of chicken muscle and adipogenic cell cultures for cultivated meat production

Haach, V.; Silveira, K. R. D.; Peixoto, M. A.; Sa, A. P. P.; Gressler, V.; Feddern, V.; Ibelli, A. M. G.; Silva, L. P.; Bastos, A. P.

10.1101/2025.05.09.652510 — bioengineering — Posted on 2025-05-14

3284 DnaB and DciA: Mechanisms of Helicase Loading and Translocation on ssDNA

Gao, N.; Mazzoletti, D.; Peng, A.; Olinares, P. D. B.; Morrone, C.; Garavaglia, A.; Gouda, N.; Tsoy, S.; Mendoza, A.; Chowdhury, A.; Cerullo, A. R.; Bhavsar, H.; Rossi, F.; Rizzi, M.; Chait, B.; Miggiano, R.; Jeruzalmi, D.

10.1101/2024.11.09.622779 — biochemistry — Posted on 2025-05-14

3285 MicroFinder: Conserved gene-set mapping and assembly ordering for manual curation of bird microchromosomes

Mathers, T. C.; Paulini, M.; Sotero-Caio, C. G.; Wood, J. M. D.

10.1101/2025.05.09.653066 — genomics — Posted on 2025-05-14

3286 Characterization of a novel heat tolerance trait and subsequent haplotype block-based analysis to identify causal regions in Dutch Holstein cattle

Pook, T.; van Pelt, M. L.; Vandenplas, J.; Adriaens, I.; Zetouni, L.; Orrett, C.; de Haas, Y.; Kamphuis, C.; Gredler-Grandl, B.

10.1101/2025.05.02.651836 — genetics — Posted on 2025-05-14

3287 Sterile insect technique reduces cabbage maggot (Diptera: Anthomyiidae) infestation in root crucifers in Canada

Fortier, A.-M.; Bush-Beaupre, A.; Savage, J.

10.1101/2025.05.09.653057 — ecology — Posted on 2025-05-14

3288 Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution

Tulloch, A. J.; Delgado, R. N.; Catta-Preta, R.; Cepko, C. L.

10.1101/2025.05.13.653746 — developmental biology — Posted on 2025-05-14

3289 Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging

Ragle, J. M.; Pooranachithra, M.; Ashley, G. E.; Cadena, E.; Blank, B.; Kang, K.; Chen, C.; Bhowmick, A. R.; Mercado, S. H.; Wells, T. E.; Clancy, J. C. C.; Chisholm, A. D.; Ward, J. D.

10.1101/2025.05.14.653803 — developmental biology — Posted on 2025-05-14

3290 Activity-Dependent Sarcomere Remodeling in C. elegans Muscle Correlates with Mechanical Vulnerability in Dystrophy

Fazyl, A.; Anbu, A.; Kollbaum, S.; Conklin, E.; Schroeder, N.; Vidal-Gadea, A. G.

10.1101/2024.08.30.610496 — molecular biology — Posted on 2025-05-14

3291 IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells

Pattu, V.; Krause, E.; Chang, H.-F.; Rettig, J.; Li, X.

10.1101/2025.05.09.652839 — molecular biology — Posted on 2025-05-14

3292 An O-acetylated derivative of piericidin A1 produced by Kitasatospora sp. A2-31 has potent activity against the cacao mirid bug, Helopeltis bakeri Poppius

Dashti, Y.; Sumang, F. A.; de los Santos, E. L. C.; Ward, A.; Amalin, D.; Alcantara, E. P.; Challis, G.

10.1101/2025.05.13.653897 — microbiology — Posted on 2025-05-14

3293 Chlamydia muridarum Infection Impacts Murine Models of Intestinal Inflammation and Cancer

Leung, G.; Carrasco, S. E.; Mourino, A. J.; Aydin, M.; Mammone, R.; Sonnenberg, G. F.; Diehl, G.; Artis, D.; Yano, H.; Arbona, R. J. R.; Lipman, N. S.

10.1101/2025.05.14.654029 — microbiology — Posted on 2025-05-14

3294 Mass Spectrometric Profiling of Microbial Polysaccharides Using Laser Desorption/Ionization - Time-of-Flight (LDI-TOF) and Liquid Chromatography/Mass Spectrometry (LC/MS): A Novel Method for Structural Fingerprinting and Derivatization

Dadovska, L.; Paskova, V.; Novak, P.; Hrabak, J.

10.1101/2025.05.13.653920 — microbiology — Posted on 2025-05-14

3295 The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics

Velez, A. Z.; Radin, J. N.; Kennedy, E. N.; Parsons, J. B.; Tong, H. M.; Jung, E.; Alam, E.; Radlinski, L. C.; Wagner, N. J.; Fowler, V. G.; Rowe, S. E.; Kehl-Fie, T.; Conlon, B. P.

10.1101/2025.05.14.654040 — microbiology — Posted on 2025-05-14

3296 Nuclear trafficking of Anelloviridae capsid protein ORF1 reflects modular evolution of subcellular targeting signals

Petersen, G. F.; Pavan, S.; Ariawan, D.; Tietz, O.; Nematollahzadeh, S.; Sarker, S.; Forwood, J. K.; Alvisi, G.

10.1101/2025.05.14.653747 — microbiology — Posted on 2025-05-14

3297 CanID-PCR: A quick and low-cost PCR tool to identify Candida species on gDNA directly extracted from positive blood bottles

Badrane, H.; Clancy, C. J.; Nguyen, M. H.

10.1101/2025.05.13.653919 — microbiology — Posted on 2025-05-14

3298 Maternal and cross-stage effects of Metarhizium fungal infection on the malaria mosquito Anopheles coluzzii life-history

SARE, I.; VIANA, M.; MILLOGO, A.; LAMY, D. L.; TENETAO, A.; BADOLO, A.; DJIGMA, F.; DIABATE, A.; BALDINI, F.; BILGO, E.

10.1101/2025.05.14.654141 — microbiology — Posted on 2025-05-14

3299 Natural killer cell function in children with severe malaria differs according to malaria transmission intensity

Turyasingura, G.; Mellencamp, K. A.; Namazzi, R.; Opoka, R. O.; John, C. C.; Hart, G. T.

10.1101/2025.05.13.653848 — immunology — Posted on 2025-05-14

3300 IL-4 and TGF-β Regulate Inflammatory cytokines and Cellular Infiltration in the Lung in Mouse-adapted SARS-CoV-2 Infection

Sima, S. T.; Puebla-Clark, L.; Gonzalez-Orozco, M.; Endrino, M. J.; Shelite, T. R.; Tseng, H.-c.; Martinez-Martinez, Y. B.; Huante, M. B.; Federman, H. G.; Gbedande, K.; Menachery, V. D.; Siracusa, M. C.; Dann, S. M.; Endsley, J. J.; Rajsbaum, R.; Stephens, R.

10.1101/2025.05.13.653138 — immunology — Posted on 2025-05-14

3301 Nonsense-mediated decay controls a negative feedback loop in innate immune sensing

Boudreault, S.; Rivera-Lopez, Y.; Ferretti, M. B.; Bonner, J.; Jacobs, B.; Lynch, K. W.

10.1101/2025.05.09.652687 — immunology — Posted on 2025-05-14

3302 Growth charts of infant visual neurodevelopment generalize across global contexts

Margolis, E. T.; Camp, C.; Sobrino, A. C.; Polanczyk, G. V.; Fatori, D.; Khula South Africa Team, ; Germina Team, ; LABS Team, ; GABA Team, ; 1kD EEG Working Group, ; 1kD Machine Learning Working Group, ; Cornelissen, L.; Berde, C. B.; Hensch, T. K.; Nelson, C. A.; Shephard, E.; Donald, K. A.; Scheinost, D.; Gabard-Durnam, L. J.

10.1101/2025.03.25.645314 — neuroscience — Posted on 2025-05-14

3303 Cerebellar Reaching Ataxia is Exacerbated by Timing Demands and Assistive Interaction Torques

Oh, K.; Cao, D.; Cowan, N.; Bastian, A. J.

10.1101/2024.10.28.620711 — neuroscience — Posted on 2025-05-14

3304 Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model

Ouellette, A. R.; O'Connell, K. M. S.; Kaczorowski, C.

10.1101/2025.05.13.653830 — neuroscience — Posted on 2025-05-14

3305 A Systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas

Chan, M.; Zhu, S.; Russell, Z.; Arora, S.; Arakaki, A.; Kumasaka, D.; Szulzewsky, F.; Michealraj, A.; Holland, E.; Gujral, T.

10.1101/2025.02.06.636949 — cancer biology — Posted on 2025-05-14

3306 Magnesium-28: A Novel Self-Theranostic Approach through Targeting Metabolic Enzyme Disruption and Intracellular Radiation.

Van Luyen, T.

10.1101/2025.05.12.653584 — cancer biology — Posted on 2025-05-14

3307 Conformational dynamics of Paxillin and its multi-modal interaction with the Focal Adhesion Targeting Domain

Bhattacharya, S.; He, Y.; Chen, Y.; Mohanty, A.; Grishaev, A.; Kulkarni, P.; Salgia, R.; Orban, J.

10.1101/2025.01.01.630265 — biophysics — Posted on 2025-05-14

3308 FastConformation: A Standalone ML-Based Toolkit for Modeling and Analyzing Protein Conformational Ensembles at Scale

Galeazzi, F. M.; Monteiro da Silva, G.; Arantes, P. R.; Varghese, I.; Shukla, A.; Rubenstein, B. M.

10.1101/2025.05.09.653048 — biophysics — Posted on 2025-05-14

3309 Universal Transformer-Based Tracker for Accurate Tracking of Particles and Cells in Microscopy

Zhang, Y.; Liu, D.; Yang, G.

10.1101/2025.05.09.653028 — bioinformatics — Posted on 2025-05-14

3310 MALER: a web server to build, evaluate, and apply machine learning models for numerical biomedical data analysis

Zhai, Z.; Lin, Z.; Li, Q.; Pan, J.

10.1101/2025.05.09.653008 — bioinformatics — Posted on 2025-05-14

3311 Reducing Manual Labour in Forensic Microtrace Recognition with Deep Learning

Rijpkema, G.; Kalisvaart, D.; Korovin, S.; Spengler, D.; Pals, A.; van der Weerd, J.; Smith, C.

10.1101/2025.05.09.653056 — bioinformatics — Posted on 2025-05-14

3312 On branch lengths assignment methods for trees with fixed topology and related biological applications

Wei, W.; Koslicki, D.

10.1101/2024.07.29.605688 — bioinformatics — Posted on 2025-05-14

3313 VEFill: a model for accurate and generalizable deep mutational scanning score imputation across protein domains

Polunina, P. V.; Maier, W.; Rubin, A. F.

10.1101/2025.05.14.653991 — bioinformatics — Posted on 2025-05-14

3314 Megabase-scale human genome rearrangement with programmable bridge recombinases

Perry, N. T.; Bartie, L. J.; Katrekar, D.; Gonzalez, G. A.; Durrant, M. G.; Pai, J. J.; Fanton, A.; Hiraizumi, M.; Ricci-Tam, C.; Nishimasu, H.; Konermann, S.; Hsu, P. D.

10.1101/2025.05.14.653916 — bioengineering — Posted on 2025-05-14

3315 A Disease-Associated Mutation Impedes PPIA Through Allosteric Dynamics Modulation

Hattori, Y.; Kumashiro, M.; Kumeta, H.; Kyo, T.; Kawagoe, S.; Matsusaki, M.; Saio, T.

10.1101/2025.05.09.653011 — biochemistry — Posted on 2025-05-14

3316 Rare variant in intracellular loop-2 of the ghrelin receptor reveals novel mechanisms of GPCR biased signaling and trafficking

Balfe, E. M.; Torbey, A.; Kohlenbach, L.; Sency, J. A.; Inoue, A.; Barak, L. S.; Gross, J. D.

10.1101/2025.03.11.642421 — biochemistry — Posted on 2025-05-14

3317 TRENDY: Gene Regulatory Network Inference Enhanced by Transformer

Tian, X.; Patel, Y.; Wang, Y.

10.1101/2024.10.14.618189 — genetics — Posted on 2025-05-14

3318 Phylogenetic analysis of pigeon paramyxovirus type 1 (PPMV-1) detected in the British Isles between 1983 - 2023.

Byrne, A. M.; Mollett, B. C.; Brown, I. H.; James, J.; Banyard, A. C.; Ross, C. S.

10.1101/2025.05.09.652871 — evolutionary biology — Posted on 2025-05-14

3319 Identifying conservation priority areas for the most under-protected globally threatened birds in Latin America

Tognelli, M. F.; Wiedenfeld, D. A.; Lebbin, D. J.; Upgren, A.; Parr, M. J.

10.1101/2025.05.09.653075 — ecology — Posted on 2025-05-14

3320 CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging

Patino, A. V.; Chapman, H.; Ginzel, J. D.; Sills, J. E.; Lyerly, H. K.; Rogers, B. W.; Drut, J. E.; Snyder, J. C.

10.1101/2025.05.09.652935 — molecular biology — Posted on 2025-05-14

3321 Glycolysis-dependent Sulfur Metabolism Orchestrates Morphological Plasticity and Virulence in Fungi

Shah, D.; M, A.; Rewatkar, N.; Gupta, S.; Mathivathanan, S.; Varahan, S.

10.1101/2025.05.14.654021 — microbiology — Posted on 2025-05-14

3322 A novel plasmid-mediated PAC β-lactamase (PAC-2) variant confers resistance to ceftazidime-avibactam in Klebsiella quasipneumoniae ST526, in Colombia.

Saavedra, S. Y.; Montilla-Escudero, E.; Ovalle, M. V.; Triana, J. A.; Torres, Y. S.; Vargas-Florez, N.; Gutierrez, M. A.; Barrera, A. F.; Duarte, C.

10.1101/2025.05.14.654127 — microbiology — Posted on 2025-05-14

3323 An approach to differentiating biological from chemical sulfide oxidation on corroded concrete sewer surfaces

Huang, X.; Yin, Y.; Zuo, Z.; Shi, T.; Kuen, T.; Zheng, M.

10.1101/2025.05.13.653906 — microbiology — Posted on 2025-05-14

3324 Cyclic di-AMP inhibits Listeria monocytogenes thymineless death during infection

Leeming, J. P.; Elkassih, O. M.; Oyebode, D. T.; Woodward, J. J.; Tang, Q.

10.1101/2025.05.14.654034 — microbiology — Posted on 2025-05-14

3325 Transposon activity eliminates a crucial fungal secondary metabolite cluster while preserving pathogenicity

Dijkstra, J.; van Westerhoven, A. C.; Li, Y.; Aguilera-Galvez, C.; Nakasato-Tagami, G.; Shi-Kunne, X.; Etalo, D. W.; Kema, G. H. J.

10.1101/2025.05.14.653967 — microbiology — Posted on 2025-05-14

3326 A reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for the rapid colorimetric detection of pepper mild mottle virus (PMMoV)

Gross, A. J.; Lopez, S.; Rogers, A.; Adkins, S.; Breitbart, M.

10.1101/2025.05.14.654098 — microbiology — Posted on 2025-05-14

3327 BONCAT-Live for isolation and cultivation of active environmental bacteria

Podar, M.; Mulay, S.; Vishnivetskaya, T. A.; Hochanadel, L.; Klingeman, D. M.; Lloyd, K. G.; Pelletier, D. A.

10.1101/2025.05.14.654084 — microbiology — Posted on 2025-05-14

3328 Peroxisomes regulate virulence and cell density sensing in Cryptococcus neoformans

Jacobs, E.; Dragotakes, Q.; dos Santos, S. R.; Smith, D. F.; Smith, B.; Wolf, J. M.; Coelho, C.; Casadevall, A.

10.1101/2025.05.14.654083 — microbiology — Posted on 2025-05-14

3329 Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism

Kamrad, S.; Mozzachiodi, S.; Blasche, S.; Aulakh, S. K.; Scheidweiler, D.; Basile, A.; Guan, R.; Bradley, R.; van den Berg, N. I.; Muelleder, M.; Ralser, M.; Patil, K. R.

10.1101/2025.05.14.653412 — microbiology — Posted on 2025-05-14

3330 Deep learning guided discovery of antibacterial polymeric nanoparticles

Wu, Y.; Wang, C.; Shen, X.; Chen, Y.; Wang, H.; Xu, B.; Chen, Y.; Dai, W.; Huang, Y.; Zou, L.; Ji, J.; Zhang, P.

10.1101/2025.05.13.653905 — microbiology — Posted on 2025-05-14

3331 Colonization with Oxalobacter formigenes slows the progression of CKD and reduces cardiac remodeling in CKD

Xiong, X.; Ho, M.; Jaber, K.; Mishra, R.; Charytan, A.; Zaidan, N.; Schlamp, F.; Fishman, G. I.; Nazzal, L.

10.1101/2025.05.14.654014 — microbiology — Posted on 2025-05-14

3332 HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

Hwang, J. K.; Marston, D. J.; Tuyishime, M.; Yang, H.; Wrapp, D.; Li, D.; Brackenridge, S.; Frazier, M.; Rhodes, B.; Harris, C. M.; Quastel, M.; Kapingidza, A. B.; Kliszczak, A.; Gater, J.; Borrow, P.; Ferrari, G.; Gillespie, G. M.; McMichael, A. J.; Haynes, B. F.; Azoitei, M. L.

10.1101/2024.07.08.602401 — immunology — Posted on 2025-05-14

3333 β-Glucan Modulates Monocyte Plasticity and Differentiation Capacity to Mitigate DSS-Induced Colitis

Lv, Y.; Fan, Y.; Gao, Q.; Chen, Q.; Hu, Y.; Wang, L.; Shi, H.; Chen, E.; Xu, Q.; Cai, Y.; Fan, Q.; Li, L.; Du, D.; Ren, J.; Cheng, S.-C.; Xu, H.

10.1101/2025.05.09.653036 — immunology — Posted on 2025-05-14

3334 Lasting Increases in Neuronal Activity and Serotonergic Receptor Expression Following Gestational Chlorpyrifos Exposure

Koenig, J. A.; Cramer, N.; Olusakin, J.; Lobo, M. K.; Keller, A.

10.1101/2025.05.09.653166 — neuroscience — Posted on 2025-05-14

3335 Unpacking the V1 map: Differential covariation of visual properties across spatial dimensions

Himmelberg, M. M.; Kwak, Y. M.; Carrasco, M.; Winawer, J.

10.1101/2025.03.19.644195 — neuroscience — Posted on 2025-05-14

3336 Multivariate Bayesian Inversion for Classification and Regression

Soch, J.; Allefeld, C.

10.1101/2025.05.09.653015 — neuroscience — Posted on 2025-05-14

3337 Fed-ComBat: A Generalized Federated Framework for Batch Effect Harmonization in Collaborative Studies

Silva, S.; Lorenzi, M.; Altmann, A.; Oxtoby, N.

10.1101/2023.05.24.542107 — neuroscience — Posted on 2025-05-14

3338 Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories

Clewett, D. V.; Huang, R.; Davachi, L.

10.1101/2024.08.15.608148 — neuroscience — Posted on 2025-05-14

3339 Alternative EEG pre-processing pipelines can lead to conflicting conclusions regarding cortical excitation/inhibition ratio

Racz, F. S.; Mac-Auliffe, D.; Mukli, P.; Milton, J.; Cabrera, J. L.; Millan, J. d. R.

10.1101/2024.11.08.622698 — neuroscience — Posted on 2025-05-14

3340 Pain and touch differentially modulate corticospinal excitability, independent of afferent inhibition

Gwynne, L.; Tame, L.

10.1101/2025.05.09.653032 — neuroscience — Posted on 2025-05-14

3341 ProGenFixer: an ultra-fast and accurate tool for correcting prokaryotic genome sequences using a mapping-free algorithm

Song, L.

10.1101/2025.05.09.653025 — bioinformatics — Posted on 2025-05-14

3342 mRNArchitect: sequence design of mRNA medicines

Budzinska, M. A.; Zardbani, M.; Sidharta, M. P.; Waterhouse, J.; Leonard, T. E.; Ghodasara, A.; Lakshman Das, S.; Chang, R. Y.; Chaudhary, N.; Cheetham, S. W.; Mercer, T. R.; Gunter, H. M.

10.1101/2024.12.03.626696 — bioinformatics — Posted on 2025-05-14

3343 UniFORM: Towards Universal Immunofluorescence Normalization for Multiplex Tissue Imaging

Wang, K.; Ait-Ahmad, K.; Kupp, S.; Sims, Z.; Cramer, E.; Sayar, Z.; Yu, J.; Wong, M. H.; Mills, G. B.; Eksi, S. E.; Chang, Y. H.

10.1101/2024.12.06.626879 — bioinformatics — Posted on 2025-05-14

3344 Azapeptide-based GLP-1 receptor agonist improves glucose metabolism in a diet-induced obesity model

VanPatten, S.; He, M.; Cheng, K. F.; Al Jabari, B.; Brines, M.; Ballarin-Gonzalez, B.; Kruse, T.; Al-Abed, Y.

10.1101/2025.05.09.653092 — biochemistry — Posted on 2025-05-14

3345 Spatial epigenomic niches underlie glioblastoma cell state plasticity

Kint, S.; Younes, S. T.; Bao, S.; Long, G.; Wouters, D.; Stephenson, E.; Lou, X.; Zhong, M.; Zhang, D.; Su, G.; Enninful, A.; Yang, M.; Chen, H.-M.; Ellestad, K.; Anderson, C.; Moliterno, J.; Kelly, J.; Chan, J. A.; Sifrim, A.; Zhou, J.; Nikolic, A.; Fan, R.; Gallo, M.

10.1101/2025.05.09.653178 — genomics — Posted on 2025-05-14

3346 Cell-cycle-dependent repression of histone gene transcription by histone H4

Ahmad, K.; Wooten, M.; Takushi, B. N.; Vidaurre, V.; Chen, X.; Henikoff, S.

10.1101/2024.12.23.630206 — genomics — Posted on 2025-05-14

3347 QWENDY: Gene Regulatory Network Inference Enhanced by Large Language Model and Transformer

Wang, Y.; Tian, X.

10.1101/2025.02.22.639640 — genetics — Posted on 2025-05-14

3348 Not just mutations: Inbreeding depression persists without genetic variation

Bonel, N.; Grunau, C.; David, P.

10.1101/2025.02.25.640231 — evolutionary biology — Posted on 2025-05-14

3349 A Notch signal required for a morphological novelty in Drosophila has antecedent functions in genital disc eversion

Shodja, D. N.; Glassford, W. J.; Rice, G. R.; Smith, S. J.; Rebeiz, M.

10.1101/2025.05.09.653167 — developmental biology — Posted on 2025-05-14

3350 Uridine cytidine kinases dictate the therapeutic response of molnupiravir via its bioactivation

Shu, H.; Sharma, S.; Alam, S.; Frank, L.; Tampere, M.; van Kuilenburg, A. B. P.; Valerie, N. C. K.; Altun, M.; Chabes, A.; Rudd, S. G.; Zhang, S. M.

10.1101/2025.05.13.653844 — microbiology — Posted on 2025-05-14

3351 Divergent Minimum Inhibitory Concentrations of Clarithromycin and Azithromycin Against Clinical Isolates of Mycobacterium abscessus Complex

Zhang, Y.; Xu, K.; Xu, P.; Cao, D.; Xiang, Y.; Dong, X.; Jiang, X.; Li, Y.; Yuan, X.; Qiu, Y.; Bi, K.; Zhang, Y.; Han, Y.

10.1101/2025.05.14.654039 — microbiology — Posted on 2025-05-14

3352 A Large Electroencephalogram Database of Freewill Reaching and Grasping Tasks for Brain Machine Interfaces

Thapa, B. R.; Boggess, J.; Bae, J.

10.1101/2025.05.09.653170 — neuroscience — Posted on 2025-05-14

3353 Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration

Pedraza, E.; R. Tejedor, A.; Feito, A.; Gamez, F.; Collepardo-Guevara, R.; Sanz, E.; R. Espinosa, J.

10.1101/2025.05.09.653068 — biophysics — Posted on 2025-05-14

3354 Hierarchical Approaches for Integrating Sparse, Multivariate Toxicological Effect Data in Whole Organism Molecular Dynamics Models

Schunck, F.; Busch, W.; Focks, A.

10.1101/2025.05.09.652942 — bioinformatics — Posted on 2025-05-14

3355 Genetic Variation in Honey Bee queen Reproductive Performance: Implications for Colony Growth and Sustainability

Li-Byarlay, H. H. L.-B.

10.1101/2025.05.09.653176 — animal behavior and cognition — Posted on 2025-05-14

3356 Seasonal assembly of the phyllosphere fungal microbiome of a perennial grass is robust to nutrient addition

Green, E.; Mitchell, C.; Carbone, I.

10.1101/2025.05.08.652919 — ecology — Posted on 2025-05-14

3357 Generation and maintenance of apical rib-like actin fibers in epithelial support cells of the Drosophila eye

Bhattarai, A.; McGhie, E. W.; Woo, J. C.; Niraula, S.; Rosetti, P.; Kim, J. M.; Popoola, E.; Johnson, R.

10.1101/2025.05.09.653141 — developmental biology — Posted on 2025-05-14

3358 Lactate metabolism antagonizes antiviral innate immunity bypromoting VDAC1-lactylation-mediated mtDNA release

Wu, Y.; Li, L.; Liu, Y.; Wang, S.; Meng, F.; Li, T.; Xiao, H.; Wan, F.; Liu, Y.; Zhou, H.; Liu, C.; Zhang, Y.; Cao, J.

10.1101/2025.05.09.653027 — cell biology — Posted on 2025-05-14

3359 Differential Decay of Multiple eNA Components from a Cetacean

Brandao-Dias, P. F.; Shaffer, M.; Guri, G.; Parsons, K. M.; Kelly, R. P.; Allan, E. A.

10.1101/2025.05.09.653189 — molecular biology — Posted on 2025-05-14

3360 The gut microbiome of the Passalid beetle has high cellulolytic potential and constitutes an unrecognized system for production of greenhouse gasses in neotropical forests

Vargas, G.; Pinto-Tomas, A. A.; Murillo-Cruz, C.; Hernandez, M.; Dierick, D.; Hernandez, C.; Soto, S.; Chaves, I. Z.; Glavina del Rio, T.; Tringe, S. G.; Clardy, J.; Sherman, D. H.; Tamayo-Castillo, G.

10.1101/2025.05.12.653568 — microbiology — Posted on 2025-05-14

3361 Improving plant functional annotation from knowledge graphs using Graph Neural Networks

Ngo, T. G. B.; Liseron-Monfils, C.; Das, S.; Ubbens, J.; Ashe, P.; Konkin, D.

10.1101/2025.05.07.652750 — systems biology — Posted on 2025-05-14

3362 Prognostically favorable immune responses to ovarian cancer are distinguished by self-reactive intra-epithelial plasma cells

Banville, A. C.; Laumont, C. M.; Singh, K.; Gladwin, B.; Dedora, J.; Mitchell, L.; Wang, J.; Miranda, A.; Mateyko, B.; Chavez, E. A.; Negri, G. L.; Cheng, S. W. G.; Smazynski, J.; Milne, K.; Wright, K.; Lampard, M.; Gierc, N.; Hamilton, P. T.; Spencer, S. E.; Kalaria, S.; Oostenbroek, T.; Negrea Puskas, V.; Steidl, C.; Morin, G. B.; Nathoo, F.; Nelson, B. H.

10.1101/2025.05.12.652297 — cancer biology — Posted on 2025-05-14

3363 A High-Dimensional Interfacial Wave Assay for Early Biophysical Profiling of Therapeutic Antibodies

St John, A. N.; Thomas, A. N.; Caramazza, P.; Meghdadi, A.; Bailey, J.; Lee, S.; Ramakrishna, V.; Amoruso, A. L. B.; Lam, E. S.-H.; Ganesh, N.; Shrivastava, S.

10.1101/2025.05.09.653084 — biophysics — Posted on 2025-05-14

3364 Genomic insights into the virulence repertoire and hemibiotrophic lifestyle of the grapevine black rot pathogen Phyllosticta ampelicida

Colombo, M.; Bettinelli, P.; Garcia, J.; Maddalena, G.; Toffolatti, S. L.; Hausmann, L.; Vezzulli, S.; Masiero, S.; Cantu, D.

10.1101/2025.05.08.652932 — genomics — Posted on 2025-05-14

3365 Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids

Suzuki, H. C.; Saito, C. T.; Rajshekar, S.; Sokabe, T.; Haji, D.; Groen, S. C.; Pelaez, J. N.; Matsunaga, T.; Takemoto, A. S.; Tanaka, K. M.; Takahashi, A.; Tominaga, M.; Saito, S.; Whiteman, N. K.

10.1101/2025.05.09.653172 — evolutionary biology — Posted on 2025-05-14

3366 Two decades of satellite images reveal the spatial and temporal dynamics of leafy spurge invasion and improve species distribution models

Lake, T. A.; Briscoe Runquist, R. D.; Moeller, D. A.

10.1101/2025.05.09.653185 — ecology — Posted on 2025-05-14

3367 Transcriptional changes in non-human primate tissues after intrathecal delivery of serotype 9 adeno-associated viral vector: insights into organ toxicities

Aihara, F.; Mardo, M.; Ruda, V.; Del Rio, T.; Bigot, K.; Singer, J.; Onishi-Seebacher, M.; Couttet, P.; Mansfield, K.; Hudry, E.

10.1101/2025.05.09.652903 — molecular biology — Posted on 2025-05-14

3368 Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface

Yin, O.; Almonte-Loya, A.; Appierdo, R.; Yang, M.; Yilmaz, B. D.; Oskotsky, T. T.; Gonzalez, J. M.; Giudice, L. C.; Afshar, Y.; Sirota, M.

10.1101/2025.05.09.653201 — molecular biology — Posted on 2025-05-14

3369 Phytoplankton and giant virus dynamics during different monsoon seasons, a fish kill, and a toxic bloom in a eutrophic mariculture area

Gajigan, A. P.; Apego, G. C. M. B.; Gianan, E. L. D.; Francisco, R. B.; Tai, J. J.; Benico, G. A.; Repollo, C. L. A.; Villanoy, C. L.; Yniguez, A. T.; Conaco, C.; Steward, G. F.

10.1101/2025.05.12.653504 — microbiology — Posted on 2025-05-14

3370 Alzheimer's subtypesA supervised, unsupervised, multimodal, multilayered embedded recursive (SUMMER) AI study

Kinreich, S.; Bingly, A.; Pandey, G.

10.1101/2025.05.09.653177 — neuroscience — Posted on 2025-05-14

3371 Improved Source Localization of Auditory Evoked Fields using Reciprocal BEM-FMM

Drumm, D. A.; Nunez Ponasso, G. C.; Linke, A.; Noetscher, G. M.; Maess, B.; Knösche, T. R.; Haueisen, J.; Lewine, J. D.; Abbott, C. C.; Makaroff, S. N.; Deng, Z.-D.

10.1101/2025.05.09.653081 — neuroscience — Posted on 2025-05-14

3372 A defined growth medium for trace metal limitation studies in Auxenochlorella sp. (UTEX 250-A) during mixotrophic growth with glucose.

Camacho, D. J.; Moseley, J. L.; Merchant, S. S.

10.1101/2025.05.09.653207 — systems biology — Posted on 2025-05-14

3373 Analysis of Microsatellite Instability Intensity in Single-Cell Resolution with scMnT reveals Tumor Heterogeneity in Colorectal Cancer

Park, G.; Park, J.

10.1101/2025.05.09.653227 — bioinformatics — Posted on 2025-05-14

3374 A unified multimodal model for generalizable zero-shot and supervised protein function prediction

Boadu, F.; Wang, Y.; Cheng, J.

10.1101/2025.05.09.653226 — bioinformatics — Posted on 2025-05-14

3375 Cell-type-specific synaptic scaling mechanisms differentially contribute to associative learning

Veneto, F.; Kepce, A.; Wu, Y. K.; Gjorgjieva, J.

10.1101/2025.05.14.654005 — neuroscience — Posted on 2025-05-14

3376 Breaking Balance: Encoding local error signals in perturbations of excitation-inhibition balance

Rossbroich, J.; Zenke, F.

10.1101/2025.05.12.653626 — neuroscience — Posted on 2025-05-14

3377 Neural sampling from cognitive maps supportsgoal-directed planning and imagination

Lin, H.; Yang, Y.; Zhao, R.; Pezzulo, G.; Maass, W.

10.1101/2025.05.14.654027 — neuroscience — Posted on 2025-05-14

3378 Mapping Macaque to Human Cortex with Natural Scene Responses

Vinken, K.; Sharma, S.; Livingstone, M.

10.1101/2025.05.11.653327 — neuroscience — Posted on 2025-05-14

3379 Parallel morphological and functional development in the Xenopus retinotectal system

Li, V. J.; Foubert, D.; Schohl, A.; Ruthazer, E. S.

10.1101/2025.05.14.654067 — neuroscience — Posted on 2025-05-14

3380 A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies

Kong, Y.; Shi, J.; Wu, F.; Zhao, T.; Wang, R.; Zhu, X.; Xu, Q.; Song, Y.; Li, Q.; Wang, Y.; Gao, X.; Yang, Y.; Wu, Y.; Yang, Z.; Yao, J.; Ying, T.

10.1101/2025.05.09.653014 — bioinformatics — Posted on 2025-05-14

3381 Molecular biointerface characterisation for an implanted medical device using cryogenic orbitrap secondary ion mass spectrometry (Cryo-OrbiSIMS)

Sabri, A. H.; Wong, K. C.; Kotowska, A. M.; Fisher, L.; Luckett, J.; Mase, J. M.; Kammerling, L.; Figueredo, G.; Scurr, D. J.; Ghaemmaghami, A. M. M.; Alexander, M. R.

10.1101/2025.05.09.652996 — bioinformatics — Posted on 2025-05-14

3382 Transcription factor NFYA directs male meiotic entry by facilitating accessible chromatin at meiotic promoters in mice

Saflund, M.; Askari, M.; Eghbali, A.; Abdi, M. M.; Östlund Farrants, A.-K.; Yu, T.; Ozata, D. M.

10.1101/2025.05.09.653044 — developmental biology — Posted on 2025-05-14

3383 Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

Neiswender, H.; Veeranan-Karmegam, R.; Pride, J. E.; Allen, P.; Neiswender, G.; Prabakar, A.; Hao, C.; Fan, X.; Gonsalvez, G.

10.1101/2025.05.13.653647 — cell biology — Posted on 2025-05-14

3384 PIN1 Drives Cellular Plasticity and Immune Modulation in Chronic Pancreatitis

Shah, V. M.; Bartlett, A.; Chen, C.; Matter, A.; Smith, A.; Zimny, H.; Wang, X.; Daniel, C.; Eng, J.; Youm, I.; Tsuda, M.; Calistri, N.; Reyer, M.; Morgan, T. K.; Dewson, G.; Waugh, T.; Keith, D.; Haverlack, S.; Xia, Z.; Chin, K.; Sheppard, B.; Brody, J.; Sears, R. C.

10.1101/2025.05.13.653850 — cell biology — Posted on 2025-05-14

3385 Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

Jones, D.; Belda, H.; Fuchs, G.; Anaguano, D.; Nofal, S. D.; Treeck, M.

10.1101/2025.05.14.653932 — cell biology — Posted on 2025-05-14

3386 Meiotic prophase I disruption as a strategy for non-hormonal male contraception using small-molecule inhibitor JQ1

Simon, L. E.; Tanis, S.; Alexander, A. K.; Horan, T.; Carro, M. d. l. M.; Bonnett, S.-J.; Ben-Shlomo, R.; Xie, A.; Danko, C. G.; Lujic, J.; Cohen, P.

10.1101/2025.05.13.653822 — cell biology — Posted on 2025-05-14

3387 Bottom-up investigation of spatiotemporal glycocalyx dynamics with interferometric scattering microscopy

Brunner, C.; Pietsch, L.; vom Sondern, I.; Roehrl, M.; Popov, C.; Trollmann, M.; Taylor, R.; Blessing, M.; Holler, C.; Almahayni, K.; Jaeschke, S. O.; Sandoghdar, V.; Boeckmann, R. A.; Lindhorst, T.; Moeckl, L.

10.1101/2025.05.09.653034 — biophysics — Posted on 2025-05-14

3388 Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks

Malady, B.; Papagiannoula, A.; Kamatar, A.; Sarkar, S.; LeBrun, G. T.; Wang, L.; Hayden, C. C.; Lafer, E. M.; Owen, D. J.; Milles, S.; Stachowiak, J.

10.1101/2025.05.13.653742 — biophysics — Posted on 2025-05-14

3389 Nanoscale precise stamping of biomolecule patterns using DNA origami

Teodori, L.; Shahrokhtash, A.; Sorensen, E. A.; Zhang, X.; Malle, M. G.; Sutherland, D. S.; Kjems, J.

10.1101/2025.05.09.653003 — bioengineering — Posted on 2025-05-14

3390 DNA-binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid-liquid phase separation

Mignon, K.; Van der Eecken, R.; Galle, M.; Demulder, M.; Van Lindt, J.; De Veylder, L.; De Greve, H.; Loris, R.

10.1101/2025.05.09.653017 — biochemistry — Posted on 2025-05-14

3391 Commensal skin bacteria interact with the innate immunesystem to promote tail regeneration in Xenopus laevis tadpoles.

Chapman, P. A.; Day, R. C.; Hudson, D. T.; Ward, J. M.; Morgan, X. C.; Beck, C. W.

10.1101/2025.05.09.653037 — developmental biology — Posted on 2025-05-14

3392 Lipid scrambling via TMEM16F mediates the formation and release of apoptotic vesicles

Le, T.; Li, Y. M.; Saric, A.; Holthuis, J.; Grinstein, S.; Freeman, S.

10.1101/2025.05.14.654002 — cell biology — Posted on 2025-05-14

3393 Phactr4 influences macrophage lamellipodial structure and dynamics through Arp2/3 complex and Ezrin regulation

Manickam, R.; Rotty, J. D.

10.1101/2025.05.13.653717 — cell biology — Posted on 2025-05-14

3394 CK1a-Mediated Two-Step Subunit Remodeling of the Circadian FRQ-FRH Complex

Schunke, C.; Ruppert, B.; Schultz, S.; Diernfellner, A. C. R.; Brunner, M.

10.1101/2025.05.13.653691 — cell biology — Posted on 2025-05-14

3395 Localizations and functions of septins are susceptible to epitope tagging

Gregory, J. R.; Llaneza, I. M.; Osmani, A. H.; Gosselin, H. E.; Wu, J.-Q.

10.1101/2025.05.13.653749 — cell biology — Posted on 2025-05-14

3396 Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy

Fernandez, B.; Passanisi, V.; Ashraf, H. M.; Spencer, S. L.

10.1101/2025.05.13.653730 — cell biology — Posted on 2025-05-14

3397 Frog-killing chytrid fungi deploy different strategies to regulate intracellular pressure in cell types that have or lack a cell wall

Prostak, S. M.; Velle, K. B.; Fritz-Laylin, L.

10.1101/2025.05.13.653819 — cell biology — Posted on 2025-05-14

3398 Optimization of mRNA Synthesis and its Cell Expression for Vaccine Development

Das, S. K.; Dutt, G.; Goswami, V.; Faiz, A.; joshi, A.

10.1101/2025.05.13.653856 — cell biology — Posted on 2025-05-14

3399 Spatial control of secretory vesicle targeting by the Ync13-Rga7-Rng10 complex during cytokinesis

Zhang, S.; Singh, D.; Zhu, Y.-H.; Zhang, K. J.; Melero, A.; Martin, S. G.; Wu, J.-Q.

10.1101/2025.05.13.653810 — cell biology — Posted on 2025-05-14

3400 Basal autophagy during meiotic prophase I is required for accurate chromosome segregation in Drosophila oocytes and declines during oocyte aging

Hilpert, D. C.; Haseeb, M. A.; Bickel, S. E.

10.1101/2025.05.13.653863 — cell biology — Posted on 2025-05-14

3401 Adhirons are efficient tools to guide antiviral ligand discovery

Simmons, K. J.; Flynn, A. J.; Derry, A. E.; Debski-Antoniak, O.; muench, s. P.; Fontana, J.

10.1101/2025.05.13.653658 — cell biology — Posted on 2025-05-14

3402 Examination of the enrichment of neuronal extracellular vesicles from cell conditioned media and human plasma using an anti-NCAM immunocapture bead approach

Collier, M. E. W.; Allcock, N.; Sylvius, N.; Cassidy, J.; Giorgini, F.

10.1101/2025.05.13.653678 — cell biology — Posted on 2025-05-14

3403 Subcellular mass spectrometry imaging of lipids and nucleotides using transmission geometry ambient laser desorption and plasma ionisation

Young, R. S. E.; Piper, A.-K.; McAlary, L.; McKinnon, J. C.; Lum, J. S.; Soltwisch, J.; Niehaus, M.; Ellis, S. R.

10.1101/2025.05.13.653655 — cell biology — Posted on 2025-05-14

3404 Physical confinement and phagocytic uptake induce directional migration

Paulson, S. G.; Liu, S.; Rotty, J. D.

10.1101/2025.05.13.653701 — cell biology — Posted on 2025-05-14

3405 Modulation of collagen-binding integrins affects fibroblast activation and inhibits fibrosis

Hamelmann, S.; Derakhshandeh, F.; Wagner, T.; Uebel, S.; Steigenberger, B.; Basquin, C.; Fabritz, S.; Schroeder-Braunstein, J.; Wabnitz, G.; Nakchbandi, I. A.

10.1101/2025.05.14.653428 — cell biology — Posted on 2025-05-14

3406 Roles of the MO25 protein Pmo25 in contractile-ring stability and localization of the NDR kinase Sid2 during cytokinesis

Ye, Y.; Zhang, S.; Osmani, A. H.; Gregory, J. R.; Goodyear, E.; Wu, J.-Q.

10.1101/2025.05.13.653815 — cell biology — Posted on 2025-05-14

3407 Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53

Jetishi, C.; Aeschlimann, S.; Schimanski, B.; Kaeser, S.; Mullner, R.; Oeljeklaus, S.; Akiyoshi, B.; Warscheid, B.; Butter, F.; Schneider, A.; Ochsenreiter, T.

10.1101/2025.05.14.653994 — cell biology — Posted on 2025-05-14

3408 Evaluating ultrastructural preservation quality in banked brain tissue

Garrood, M.; Keberle, A.; Sowa, A.; Janssen, W.; Thorn, E. L.; De Sanctis, C.; Farrell, K.; Crary, J. F.; McKenzie, A. T.

10.1101/2025.05.09.652503 — neuroscience — Posted on 2025-05-14

3409 Secreted small RNAs of Naegleria fowleri as biomarkers for diagnosis of primary amoebic meningoencephalitis

Russell, A. C.; Dainis, J.; Alexander, J.; Ali, I. K. M.; Kyle, D. E.

10.1101/2025.01.11.632551 — microbiology — Posted on 2025-05-14

3410 Integrating Recombinase-Based Feedback and Feedforward Control for Optimal Resource Decoupling

Zhang, R.; Zhang, R.; Tian, X.-J.

10.1101/2025.05.13.653855 — synthetic biology — Posted on 2025-05-14

3411 Simultaneous observation of RNAs and their binding proteins in plant cells

Ma, J.; Wang, Y.; Folimonova, S. Y.; Liu, B.; Wang, Y.

10.1101/2024.09.27.615539 — plant biology — Posted on 2025-05-14

3412 Prenatal exposure to dietary levels of glyphosate disrupts metabolic, immune, and behavioral markers across generations in mice.

Barnett, J. A.; Josephson, J. K.; Haskey, N. A.; Hart, M. M.; Soma, K. K.; Verdugo, A.; McComb, C. J.; Bandy, M. L.; Ghosh, S.; Letef, C.; Copp, A.; Ishida, R.; Yuzbashian, E.; Gibon, J.; Ye, J.; Giebelhaus, R. T.; Murch, S. J.; Jung, M. M.; Gibson, D. L.

10.1101/2024.08.27.609990 — pharmacology and toxicology — Posted on 2025-05-14

3413 Live Cell Extrusion in Cervical Cancer - A Novel Mechanism for Cancer Progression

Rose, L.; Krishna, S.

10.1101/2025.05.13.653891 — cancer biology — Posted on 2025-05-14

3414 Computation model predicts Rho GTPase function with the Plexin Transmembrane receptor GAP activity on Rap1b via dynamic allosteric changes

Bhattarai, N.; Morrison, L.; Gomes, A. F.; Savage, P.; Sahoo, A. R.; Buck, M.

10.1101/2025.03.13.643120 — biophysics — Posted on 2025-05-14

3415 {Omega}-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

Chen, S.; Mack, A. R.; Hujer, A. M.; Bethel, C. R.; Bonomo, R. A.; Haider, S.

10.1101/2024.02.04.578824 — biophysics — Posted on 2025-05-14

3416 iModMix: Integrative Module Analysis for Multi-omics Data

Narvaez-Bandera, I. Y.; Lui, A.; Mekonnen, Y. A.; Rubio, V.; Sulman, N.; Wilson, C. M.; Ackerman, H.; Ospina, O.; Gonzalez-Calderon, G.; Flores, E.; Li, Q.; Chen, Y. A.; Fridley, B.; Stewart, P. A.

10.1101/2024.11.12.623208 — bioinformatics — Posted on 2025-05-14

3417 Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant Calling

Hu, J.; Freed, D.; Feng, H.; Chen, H.; Li, Z.; Chen, H.

10.1101/2025.04.15.648987 — bioinformatics — Posted on 2025-05-14

3418 Enhanced protein precipitation with ammonia enables rapid, universal extraction of oligonucleotides for bioanalysis

Kamali, A.; Shelke, J. D.; Sanford, E. J.; Hayashi, M. M.; Chaisakhon, N.; Kolakowski, R. V.; Puri, S.; Zhang, G.

10.1101/2025.04.24.650521 — biochemistry — Posted on 2025-05-14

3419 Mapping nonhuman cultures with the Animal Culture Database

Basava, K.; Alam, M. N. U.; Roberts, L.; Martinet, K.; Cherry, P.; Garcia-Verdugo, H.; Roman-Palacios, C.

10.1101/2025.02.26.640400 — animal behavior and cognition — Posted on 2025-05-14

3420 From Criticism to Collaboration: Empowering Built-Environment Professionals for Biodiversity-inclusive Cities in the Global North and South

Lu, J.; Li, L.; Hernando, A.; Manzanera, J. A.

10.1101/2025.01.15.633110 — ecology — Posted on 2025-05-14

3421 FOSL2 regulates gonadotropin-dependent folliculogenesis through feedback amplification of FSH/FSHR signaling

Shi, H.; Chen, C.; Ran, Z.; Liao, J.; Wu, Z.; Wang, X.; Zhao, Y.; Ke, W.; Tan, B.; Liu, Y.; Su, Y.; Ren, W.; Li, X.; He, C.

10.1101/2025.03.11.642212 — cell biology — Posted on 2025-05-14

3422 The extra-terminal domain drives the role of BET proteins in transcription

Pasionek, I.; Machowska, A.; Ridenour, J. B.; Donczew, M.; Donczew, R.

10.1101/2025.05.12.653540 — molecular biology — Posted on 2025-05-14

3423 Competition with Pseudomonas aeruginosa induces Staphylococcus aureus in an antibiotic-tolerant viable but non culturable state

Lapinska, U.; Chandran, G.; Tunstall, T.; Zborowsky, S.; Tolle, G.; Verderosa, A.; Garcia Castillo, M.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; Young, A. R.; Canton, R.; Caboni, P.; Blaskovich, M.; Warris, A.; Tsaneva-Atanasova, K.; Pagliara, S.

10.1101/2025.04.30.651255 — microbiology — Posted on 2025-05-14

3424 Systematic functional assessment of antiphage systems in their native host

David, E.; Plantady, C.; Poissonnier, S.; Elliott, J.; Kenck, E.; Le Boulch, J.; Gutierrez, A.; Chevallereau, A.

10.1101/2024.12.20.629700 — microbiology — Posted on 2025-05-14

3425 Activity of Human-Specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome

Anding, A.; Ren, B.; Padmashri, R.; Burkovetskaya, M.; Dunaevsky, A.

10.1101/2025.02.26.640426 — neuroscience — Posted on 2025-05-14

3426 An open, fully-processed data resource for studying mood and sleep variability in the developing brain

Brook, J. B. H.; Salo, T.; Luo, A. C.; Bagautdinova, J.; Rush, S.; Alexander-Bloch, A. F.; Baller, E. B.; Calkins, M. E.; Cieslak, M.; Cooper, E. C.; Detre, J. A.; Elliot, M. A.; Fair, D. A.; Freedman, P.; Gehrman, P. R.; Gur, R. C.; Gur, R. E.; Klein, A.; Laney, N.; Laumann, T. O.; Mehta, K.; Merikangas, K.; Milham, M. P.; Mitchell, J. A.; Moore, T. M.; Nelson, S. M.; Ruparel, K.; Sevchik, B. L.; Shanmugan, S.; Shou, H.; Taso, M.; White, L. K.; Wolf, D. H.; Tisdall, D.; Roalf, D. R.; Satterthwaite, T. D.

10.1101/2025.05.01.651544 — neuroscience — Posted on 2025-05-14

3427 A simple method to efficiently generate structural variation in plants

Bechen, L. L.; Ahsan, N.; Bahrainwala, A.; Gehring, M.; Rajavasireddy, S.

10.1101/2024.12.20.629831 — plant biology — Posted on 2025-05-14

3428 Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound Epromoters

Swaminathan, G.; Cordero, J.; Guenther, S.; Graumann, J.; Braun, T.; Dobreva, G.; Barreto, G.

10.1101/2025.05.13.653883 — cancer biology — Posted on 2025-05-14

3429 Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes

Hamann, M. V.; Godbole, S.; Adiba, M.; Leddy, S.; Navolic, J.; Tabatabai, G.; Merk, D. J.; Lange, U. C.; Neumann, J. E.

10.1101/2025.05.13.653713 — cancer biology — Posted on 2025-05-14

3430 Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer

10.1101/2025.05.13.653839 — cancer biology — Posted on 2025-05-14

3431 A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

de Jong, G.; Memi, F.; Gracia, T.; Lazareva, O.; Gould, O.; Aivazidis, A.; Dave, M.; Zhang, Q.; Jensen, M.; Rifaioglu, A. S.; Barros-Silva, J. D.; Eckert, S.; Zhou, D.; Wood, Y.; Tuck, E.; Er, S.; Marshall, H.; Roberts, K.; Trinh, A. L.; Rai, S.; Shaw, T.; Oszlanczi, A.; Powell, H.; Petryszak, R.; Katsirea, Z.; Mamun, I.; Mulas, I.; Quaegebeur, A.; Briggs, M.; Makarchuk, S.; Cox, J.; Lee, J. T. H.; Rueda, L.; Saraswat, M.; Bulstrode, H.; Young, A.; Patel, M.; Porter, T.; Prigmore, E.; Mall, M.; Saez-Rodriguez, J.; Briscoe, J.; Rowitch, D. H.; Mair, R.; Behjati, S.; Stegle, O.; Bayraktar, O. A.

10.1101/2025.05.13.653495 — cancer biology — Posted on 2025-05-14

3432 Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

Sinanidis, I.; Tsakiroglou, P.; Dubner, B.; Foertsch, R.; Gondek, J.; Choi, I.; Paun, B.; Zhao, L.; Ghiaur, G.; Dalton, W. B.

10.1101/2025.05.13.651470 — cancer biology — Posted on 2025-05-14

3433 SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.

Ortmann, B.; Bertlin, J. A. C.; Seear, R. V.; Arnaiz, E.; Lin, S.; Salman, A. M.; Wilson, L.; Harris, A. L.; Stewart, G. D.; Hepburn, A.; Clare, S.; Robson, C. N. N.; Speak, A. O.; Nathan, J. A.

10.1101/2025.05.13.653699 — cancer biology — Posted on 2025-05-14

3434 THE IMMUNE RESPONSE AGAINST CANCER IS MODULATED BY STROMAL CELL FIBRONECTIN

Lubosch, A.; Pitt, L.; Zoeller, C.; Wirth, F.; Exner, T.; Steigenberger, B.; Schroeder-Braunstein, J.; Wabnitz, G.; Nakchbandi, I. A.

10.1101/2025.05.14.653424 — cancer biology — Posted on 2025-05-14

3435 EZH2 alters aggressive variant prostate cancer subtype evolution, but is not required for neuroendocrine prostate cancer

Jacobi, J. J.; Wadosky, K. M.; Jaiswal, N.; Zhang, X.; Wang, Y.; Singh, P.; Wang, J.; Gomez, E. C.; Wang, J.; Xu, B.; Cejas, P.; Kukreja, S.; LONG, H. W.; Goodrich, D. W.

10.1101/2025.05.13.653549 — cancer biology — Posted on 2025-05-14

3436 Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect

Moon, E. J.; Vilaplana Lopera, N.; Kim, J.; Nam, G.; Tullis, I. D. C.; Paillas, S.; Ruan, J.-L.; Jiang, Y.; Park, S.; Lee, P. J.; Hou, T.; Walker, E.; Abu-Halawa, A.; Hill, M. A.; Choi, C.; Lee, I. J.; Jeong, Y.; Lakhal-Littleton, S.; Then, C. K.; Shen, S.-C.; Giaccia, A.; Petersson, K.

10.1101/2025.05.14.653978 — cancer biology — Posted on 2025-05-14

3437 First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers

Luck, C.; Jacobs, K. A.; Riad, J.; Macaraig, C. D.; Ponce, R. K. M.; Okimoto, R. A.

10.1101/2025.05.13.653825 — cancer biology — Posted on 2025-05-14

3438 scGenAI: A generative AI platform with biological context embedding of multimodal features enhances single cell state classification

Wang, R.; Ung, M.; Ge, H. G.

10.1101/2025.05.07.652733 — bioinformatics — Posted on 2025-05-14

3439 Improving the monitoring of the invasive Blue Crab (Callinectes sapidus): combining environmental DNA and citizen observations

Delrieu-Trottin, E.; Bianic, M.; Miaud, C.; Garcia, M.; Arnal, V.; Hocde, R.; Cochet, C.; Barre, N.; Cornil, L.; Manel, S.

10.1101/2024.10.24.620022 — ecology — Posted on 2025-05-14

3440 Dogs gone wild: habitat use and ecological impacts of feral dogs in sub-Antarctic Chile

Tebelmann, H.; Kaefer, S.; Pages, A. S.; Ruiz, A. C.; Volkart, N. S.; Ganslosser, U.

10.1101/2025.05.08.652634 — ecology — Posted on 2025-05-14

3441 Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

Francavilla, R.; Chattopadhyaya, B.; Damo Kamda, J. L.; Jadhav, V.; Kourrich, S.; Michaud, J. L.; Di Cristo, G.

10.1101/2024.02.27.582362 — neuroscience — Posted on 2025-05-14

3442 Blue light increases stomatal conductance and photosynthesis in Agave hybrid

Sartori, H. L.; Silva, S. J.; Cruz, L. P.; Laira, M. D.; Raya, F. T.; Pereira, G. A.; Ribeiro, R. V.

10.1101/2025.05.13.653724 — plant biology — Posted on 2025-05-14

3443 Membranous interacting partners of phage-type plastid RNA polymerase have limited impact on plastid gene expression during chloroplast development

Kurotaki, Y.; Nishino, A. S.; Fujii, S.

10.1101/2025.05.13.653719 — plant biology — Posted on 2025-05-14

3444 Selective killing of cancer cells via simultaneous destabilization of mitochondrial iron metabolism and induction of ferroptosis elicited by mitochondrially targeted iron chelator deferasirox

Jadhav, S. B.; Sandoval Acuna, C.; Pacior Pampin, Y.; Klanicova, K.; Blazkova, K.; Sedlacek, R.; Stursa, J.; Werner, L.; Truksa, J.

10.1101/2024.01.17.575692 — cancer biology — Posted on 2025-05-14

3445 Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude

Hansen, A. S.; Mazzocca, M.; Narducci, D. N.; Grosse-Holz, S.; Matthias, J.

10.1101/2025.05.10.653248 — biophysics — Posted on 2025-05-14

3446 Individual heterogeneity drives a plant macroparasites life history

Spacey, O. G.; Jones, O. R.; Record, S.; Janssen, S. D.; Yue, A. Y.; Liu, W.; Rosen, A.; Thorogood, C. J.; Salguero-Gomez, R.

10.1101/2025.05.09.653086 — ecology — Posted on 2025-05-14

3447 Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease (V1)

Chocarro, J.; Marana, S.; Espelosin, M.; Rico, A. J.; Ariznabarreta, G.; Lorenzo-Ramos, E.; Illarduya, M. M.; Hernandez-Alcoceba, R.; Chillon, M.; Vila, M.; Kordower, J.; Schapira, A. H. V.; Garcia-Osta, A.; Cuadrado-Tejedor, M.; Lanciego, J. L.

10.1101/2025.05.09.653000 — neuroscience — Posted on 2025-05-14

3448 Distinct neural representational geometries of numerosity in early visual and association regions of dorsal and ventral streams

Karami, A.; Castaldi, E.; Eger, E.; Piazza, M.

10.1101/2023.12.18.571155 — neuroscience — Posted on 2025-05-14

3449 Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose-dependent manner

Ugliara, L.; Orssatto, L. B. R.; Vieira, A.; Trajano, G. S.

10.1101/2025.01.16.633442 — neuroscience — Posted on 2025-05-14

3450 On the taxonomy and nomenclature of the annual species of the Brachypodium distachyon grass complex (Gramineae, Pooideae)

GALLEGO, P. P. F.; Fabado, J.; Catalan, P.

10.1101/2025.05.13.653784 — plant biology — Posted on 2025-05-14

3451 It's all in the timing: vegetative phase change alters selection under drought and contributes to local adaptation

Lawrence-Paul, E. H.; Janakiraman, J.; Lawrence-Paul, M. R.; Ben-Zeev, R.; Penn, A.; Lasky, J. R.

10.1101/2025.05.13.653704 — plant biology — Posted on 2025-05-14

3452 The HORMA-domain protein ASY1 recruits the plant-specific cyclin SDS to promote DMC1-mediated meiotic recombination

Cai, B.; Yuan, X.; Luo, Y.; Cao, F.; Zhang, Y.; Zhuang, J.; Geng, M.; Chu, L.; Schnittger, A.; Yang, C.

10.1101/2025.05.13.653901 — plant biology — Posted on 2025-05-14

3453 Determinants of fleshiness or dryness for fruits at maturity: fruit shapes and pericarp permeability

Yu, S.; Liu, C.; Liu, H.; Gao, X. O.; Baskin, C.

10.1101/2025.05.13.653672 — plant biology — Posted on 2025-05-14

3454 Multiplexed profiling of transcriptional regulators in plant cells

Alamos, S.; Waldburger, L.; Dee, A.; Owens, L.; Rattan, R.; Ong, S.; Shih, P.

10.1101/2025.05.12.653590 — plant biology — Posted on 2025-05-14

3455 Earlier leaf out and loss of cold tolerance for northeastern U.S. trees in response to winter warming events and early springs

Pinover, L. K.; Butnor, J. R.; Fisichelli, N.; Murakami, P.; Rogers, N.; Zhang, Y.-J.; Wason, J.

10.1101/2025.05.14.653502 — plant biology — Posted on 2025-05-14

3456 Synergistic 3D, multispectral, and thermal image analysis via supervised machine learning for improved detection of root rot symptoms in hydroponically-grown flat-leaf parsley

Agarwal, A.; de Jesus Colwell, F.; Bello Rodriguez, J.; Sommer, S.; Barman, M.; Correa Galvis, V. A.; Hill, T. R.; Boonham, N.; Prashar, A.

10.1101/2025.05.14.653930 — plant biology — Posted on 2025-05-14

3457 Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in Non-Small cell Lung Cancer patients undergoing anti-PD1 therapy

Jain, K.; Goel, A.; Mehra, D.; Rathore, D. K.; Binayke, A.; Aggarwal, S.; Ganguly, S.; Awasthi, A.; MADAN, D. E.; Ganguly, N. K.

10.1101/2025.05.13.653410 — cancer biology — Posted on 2025-05-14

3458 SoftAlign: End-to-end protein structures alignment

Trinquier, J.; Petti, S.; Park, S.; Herath, K.; van Kempen, M.; Feng, S.; Söding, J.; Steinegger, M.; Ovchinnikov, S.

10.1101/2025.05.09.653096 — bioinformatics — Posted on 2025-05-14

3459 SDS-22 stabilizes the PP1 catalytic subunits GSP-1/-2 contributing to polarity establishment in C. elegans embryos

Li, Y.; Calvi, I.; Gotta, M.

10.1101/2025.01.07.631699 — cell biology — Posted on 2025-05-14

3460 In situ profiling of plasma cell clonality with image-based single-cell transcriptomics

Yang, E.; Aceves-Salvador, J.; Castrillon, C.; Herrmann, U. S.; Akama-Garren, E. H.; Carroll, M. C.; Moffitt, J. R.

10.1101/2025.05.09.653118 — immunology — Posted on 2025-05-14

3461 Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

Asopa, A.; Bhalla, U. S.

10.1101/2024.10.30.621034 — neuroscience — Posted on 2025-05-14

3462 Delayed forebrain excitatory and inhibitory neurogenesis inSTRADA-related megalencephaly via mTOR hyperactivity

Pan, T.; Lin, G.; Li, X.; VanHeyningen, D.; Walker, J. C.; Kohli, S.; Saravanan, A.; Amrita, A.; Jaklic, D. C.; Pantoja-Gutierrez, S.; Vaid, S.; Sturza, J.; Inoki, K.; Imamichi, T.; Chang, W.; Dang, L. T.

10.1101/2025.05.13.653911 — neuroscience — Posted on 2025-05-14

3463 Predicting Neural Activity from Connectome Embedding Spaces

Zhang, Z.; Zhang, H.; Mihalas, S.

10.1101/2025.05.09.653224 — neuroscience — Posted on 2025-05-14

3464 Information theoretic measures of neural and behavioural coupling predict representational drift

Heiney, K.; Jozsa, M.; Rule, M. E.; Sprekeler, H.; Nichele, S.; O'Leary, T.

10.1101/2025.05.12.653436 — neuroscience — Posted on 2025-05-14

3465 Mechanism of formin-mediated filament nucleation from profilin-actin

Zweifel, M. E.; Courtemanche, N.

10.1101/2025.05.09.653129 — biophysics — Posted on 2025-05-14

3466 Comparative analysis of CRISPR/Cas9-targeted nanopore sequencing approaches in repeat expansion disorders

Benarroch, L.; Boelle, P.-Y.; Madry, H.; Mohand Oumoussa, B.; Eura, N.; Nishino, I.; Labreche, K.; Gorbunova, V.; Bassez, G.; Stojkovic, T.; Gourdon, G.; Bonne, G.; Tome, S.

10.1101/2024.12.04.626786 — bioinformatics — Posted on 2025-05-14

3467 iDRKAN: Interpretable miRNA-Disease Association Prediction Based on Dual-Graph Representation Learning and Kolmogorov-Arnold Network

Zhu, Y.; Fan, Y.; Sun, G.; Li, X.

10.1101/2025.02.11.637780 — bioinformatics — Posted on 2025-05-14

3468 TidyMass2: Advancing LC-MS Untargeted Metabolomics Through Metabolite Origin Inference and Metabolic Feature-based Functional Module Analysis

Wang, X.; Liu, Y.; Jiang, C.; Huang, Z.; Yan, H.; Wong, S.; Johnson, C.; Zhang, J.; Ge, Y.; Zhang, F.; Lai, R.; Gao, P.; Zhang, X.; Shen, X.

10.1101/2025.05.09.652992 — bioinformatics — Posted on 2025-05-14

3469 WITHDRAWN: Diversity of diazotrophs in the Northern Pacific Ocean and sensitivity of the symbiotic unicellular cyanobacteria (UCYN-A) to inorganic nitrogen availability

Reed, G. M.

10.1101/2025.04.05.647397 — bioinformatics — Posted on 2025-05-14

3470 HYDRA: Fabrication of cell culture HYDrogels by Robotic liquid handling Automation for high-throughput drug testing

Torchia, E.; Di Sante, M.; Horda, B.; Mihajlovic, M.; Zimmermann, J.; Pezzotti, M.; Cimetta, E.; Gabriele, S.; Auricchio, F.; Lind, J. U.; Enrico, A.; Pasqualini, F. S.

10.1101/2024.12.22.629679 — bioengineering — Posted on 2025-05-14

3471 Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly

Castelvecchi, G.; Li, L.; Shin, J.; Villarreal, N. L.; Roszko, I.; Gontarz, P.; Li, T.; Zhang, B.; Sepich, D.; Krezel, L. S.

10.1101/2025.05.10.653271 — developmental biology — Posted on 2025-05-14

3472 ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis

Burda, I.; Brauns, F.; Shipman, A.; Shapland, E.; Hong, L.; Roeder, A. H. K.

10.1101/2025.05.09.653143 — developmental biology — Posted on 2025-05-14

3473 Extracellular stiffness regulates cell fate determination and drives the emergence of evolutionary novelty in teleost heart

Matsuki, S.; Inoue, Y.; Watanabe, R.; Mitsui, T.; Moriyama, Y.

10.1101/2025.05.13.653630 — developmental biology — Posted on 2025-05-14

3474 Mechanisms of force transmission on cytokinesis Formin Cdc12 in fission yeast revealed by coiled-coil force sensors

Saito, T.; Ren, Y.; Berro, J.

10.1101/2025.05.14.653946 — cell biology — Posted on 2025-05-14

3475 A novel pH-sensitive probe to quantify autophagy on high throughput/content imaging platforms

Ciccotosto, G. D.; Jana, M.; Galluzzi, L.; Mitchell, L.; Gupta, P.; Furness, S. G. B.; Lazarou, M.; Hare, D. L.; Wookey, P. J.

10.1101/2025.05.13.653902 — cell biology — Posted on 2025-05-14

3476 Non-redundant cardiolipin synthases shape membrane composition and support stress resilience in Bacteroides fragilis

Schnizlein, M. K.; Hong, B. J.; Nguyen, J. N. T.; Jones, K.; Rodriguez, A. I.; Fiebig, A.; Campagna, S. R.; Balunas, M. J.; O'Halloran, T. V.; Crosson, S.

10.1101/2025.05.12.653583 — microbiology — Posted on 2025-05-14

3477 Genomic differentiation of Mannheimia haemolytica genotypes

Deschner, D.; Hill, J. E.

10.1101/2025.05.13.653884 — microbiology — Posted on 2025-05-14

3478 Independent Generation of Amyloid-β via Novel APP Transcripts

Gustavsson, E. K.; Abel, E.; Macpherson, H.; Brinkmalm, G.; Piotrowska, D.; Wagen, A. Z.; Montgomery, K.; Villegas Llerena, C.; Alvarez Giovannucci, T.; de Silva, R.; Heslegrave, A.; Fox, N.; Zetterberg, H.; Houlden, H.; Hardy, J.; Wray, S.; Arber, C.; Ryten, M.

10.1101/2025.05.13.651054 — neuroscience — Posted on 2025-05-14

3479 Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models

Choudhary, A.; Rosh, I.; Hussein, Y.; Netser, S.; Suliman, T.; Shemen, A.; Rike, W. A.; Simchi, L.; Shklyar, B.; Abu-Akel, A.; Zinger, A.; Offen, D.; Wagner, S.; Stern, S.

10.1101/2024.08.27.609917 — neuroscience — Posted on 2025-05-14

3480 Lifespan Trajectories of Alpha Rhythm: Dynamic Shifts in Neural Excitation-Inhibition Balance

Han, C.; Cheung, V. C. K.; Chan, R. H. M.

10.1101/2025.05.14.653960 — neuroscience — Posted on 2025-05-14

3481 Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish

Hillman, C. S.; Petracco, G.; Fontana, B. D.; Scaia, M. F.; Dalla Vecchia, E.; Wetton, J. H.; Norton, W. H.; Parker, M. O.; Reichmann, F.

10.1101/2025.05.12.653402 — neuroscience — Posted on 2025-05-14

3482 Cell-type-specific encoding of prediction and reward in cortical microcircuits during novelty detection

Sharafeldin, A.; Choi, H.

10.1101/2025.05.13.653877 — neuroscience — Posted on 2025-05-14

3483 Perisynaptic astroglial response to in vivo long-term potentiation and concurrent long-term depression in the hippocampal dentate gyrus.

Nam, A. J.; Kuwajima, M.; Parker, P. H.; Bowden, J. B.; Abraham, W. C.; Harris, K. M.

10.1101/2025.05.13.653827 — neuroscience — Posted on 2025-05-14

3484 Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model

Ouellette, A. R.; O'Connell, K. M. S.; Kaczorowski, C.

10.1101/2025.05.13.653830 — neuroscience — Posted on 2025-05-14

3485 Beyond PAM50: Unsupervised Discovery of Anomalous Subgroups in Breast Cancer

gairola, t.

10.1101/2025.05.11.653361 — cancer biology — Posted on 2025-05-14

3486 araCNA: Somatic copy number profiling using long-range sequence models

Visscher, E.; Yau, C.

10.1101/2025.01.20.633608 — cancer biology — Posted on 2025-05-14

3487 McsB regulates CtsR thermosensing through periphery arginine phosphorylation

Cai, H.; Hua, B.; Hu, J.; Fu, Y.; Ding, X.; Duan, G.; Guo, Y.; Xia, X.-H.; Zhao, Y.

10.1101/2024.12.26.630380 — biophysics — Posted on 2025-05-14

3488 Self-driving development of perfusion processes for monoclonal antibody production

Mueller, C.; Vuillemin, T.; Gadiyar, C. J.; Souquet, J.; Bielser, J. M.; Fagnani, A.; Sokolov, M.; von Stosch, M.; Feidl, F.; Butte, A.; Cruz Bournazou, M. N.

10.1101/2024.09.03.610922 — bioengineering — Posted on 2025-05-14

3489 Colony demographics shape nest construction in Camponotus fellah ants

Rajendran, H.; Weinberger, R.; Fonio, E.; Feinerman, O.

10.1101/2024.07.09.602713 — animal behavior and cognition — Posted on 2025-05-14

3490 Dietary Interventions Modulate Cell Competition and Locomotor Decline in an Alzheimer's Disease Drosophila Model

Costa-Rodrigues, C.; Jacobs, J. R.; Couceiro, J.; Bras-Pereira, C.; Moreno, E.

10.1101/2025.05.12.653450 — cell biology — Posted on 2025-05-14

3491 Epithelial eversion, a collective rearrangement from apical-in to apical-out polarity, is initiated by α6β4 integrins and sustained by increased cell proliferation and anchorage-independence

Patel, N.; Pirrello, J.; Priya, S.; Manninen, A.; Conway, D. E.

10.1101/2025.05.12.653281 — cell biology — Posted on 2025-05-14

3492 Single-Cell Metabolic Imaging Reveals Glycogen Driven-Adaptations in Endothelial Cells

Chadha, R. S.; Yang, B.; Yuan, D.; Kocheril, P. A.; Mahajan, S.; Colazo, A.; Malhi, N. K.; Ambarian, J. A.; Liu, X.; Chen, Z. B.; Wei, L.

10.1101/2025.05.11.653328 — cell biology — Posted on 2025-05-14

3493 HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A

Nguyen, N. G. T.; Sapkota, H.; Shibata, Y.; Fesiuk, A.; Antalek, M.; Sail, V.; Ansel, D. J.; Amici, D. R.; Peelor, F. F.; Van Remmen, H.; Miller, B. F.; Mendillo, M. L.; Morimoto, R. I.; Li, J.

10.1101/2025.05.12.653547 — cell biology — Posted on 2025-05-14

3494 Histone acetylation alters nuclear morphology and architecture of human mesenchymal stem cells in rigidity dependent manner

Majumder, A.; Joshi, R.; shah, D.; Venkatesh, K.

10.1101/2025.05.12.652695 — cell biology — Posted on 2025-05-14

3495 Intensity Modulation of Trichromatic Split Fluorescent Proteins for Live Cell Mapping

Ishii, M.; Kinjo, T.; Kondo, Y.; Terai, K.; Aoki, K.; Kuhlman, B.; Matsuda, M.

10.1101/2025.05.13.653616 — cell biology — Posted on 2025-05-14

3496 Nuclear phenotypic changes in cells originating from migrating tenocytes in tendon explants

dos Anjos, E. H.; Mello, M. L. S.; Vidal, B. D.

10.1101/2025.05.10.653257 — cell biology — Posted on 2025-05-14

3497 Lipid Droplets are active translation depots that respond to infection

Jha, R. M.; Menon, D.; Nahak, A.; Kumar, A.; Choudhary, V.; Gandotra, S.

10.1101/2025.05.12.653387 — cell biology — Posted on 2025-05-14

3498 EVALUATION OF STAINING FOR FIBRONECTIN ISOFORMS IN LIVER DISEASES

Hamelmann, S.; Sarmiento, J.; Bung, T.; Menhem, M.; Cohen, A. J.; Gooch, G.; Thevenot, P.; Burshell, A.; Nakchbandi, I. A.

10.1101/2025.05.14.653452 — cell biology — Posted on 2025-05-14

3499 Receptor agonist of NFκB signaling ligand directs lung epithelial cell expansion through RANK signaling

Habibie, H.; Vlasma, J. R.; Putri, K.; Song, S.; Jager, M. d.; Petersen, A.; Boorsma, C. E.; Cool, R. H.; Quax, W.; Nawijn, M.; Timens, W.; Burgess, J. K.; Brandsma, C.-A.; Melgert, B. N.

10.1101/2025.05.13.648716 — cell biology — Posted on 2025-05-14

3500 Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia

Zhang, J.; Wu, W.; Wang, Y.; Zhang, Y.; Wang, Y.; Bai, W.; Zhang, Z.; Zhu, C.; Wu, Y.; Zhang, Z.; Yang, L.; Lei, H.; Xu, H.; Zhou, L.; Wu, Y.

10.1101/2025.05.11.653221 — cell biology — Posted on 2025-05-14

3501 Methionine-triggered growth arrest reveals activation of Gcn2 by methionine transporter endocytosis

Hepowit, N. L.; Singkhek, H. L.; Johnson, D. J.; MacGurn, J. A.

10.1101/2025.05.12.653625 — cell biology — Posted on 2025-05-14

3502 The biomolecular profiles of extracellular vesicles from odontogenic stem cell lines depict donor-dependent differences and emphasize their therapeutic and regenerative potential

Xu, Y.; Sarisoy, A.; Buhl, M.; Silva, A. S.; Gonzalez Rubio, J.; Thiebes, A. L.; Fuest, S.; Smeets, R.; Ricklefs, F. L.; Apel, C.

10.1101/2025.05.13.653575 — cell biology — Posted on 2025-05-14

3503 In vivo evolution of Candida auris multi-drug resistance in a patient receiving antifungal treatment

Wang, T. W.; Putnam, N.; Johnson, J. K.; Jabra-Rizk, M. A.

10.1101/2025.05.13.653818 — microbiology — Posted on 2025-05-14

3504 From cognition to compensation: Neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

Zhu, R.; Wang, H.; Feng, C.; Yin, L.; Zhang, R.; Liu, C.

10.1101/2025.05.08.652959 — neuroscience — Posted on 2025-05-14

3505 Gene regulatory network transitions reveal the central transcription factors in lung adenocarcinoma progression

Ray, U.; Singh, A.; Samanta, D.; Dhar, R.

10.1101/2025.05.13.651789 — systems biology — Posted on 2025-05-14

3506 "Cold" Orthogonal Translation: A Psychrophilic Pyrrolysyl-tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Koch, N. G.; Goettig, P.; Nash, M. A.; Rappsilber, J.; Budisa, N.

10.1101/2023.05.23.541947 — synthetic biology — Posted on 2025-05-14

3507 Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition

Watanabe, K.; Takeda, K.; Iijima, S.; Nagahiro, T.; Ikegaya, Y.; Matsumoto, N.

10.1101/2025.05.08.652893 — pharmacology and toxicology — Posted on 2025-05-14

3508 Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in Non-Small cell Lung Cancer patients undergoing anti-PD1 therapy

Jain, K.; Goel, A.; Mehra, D.; Rathore, D. K.; Binayke, A.; Aggarwal, S.; Ganguly, S.; Awasthi, A.; MADAN, D. E.; Ganguly, N. K.

10.1101/2025.05.13.653410 — cancer biology — Posted on 2025-05-14

3509 RNA3DClust: unsupervised segmentation of RNA 3D structuresusing density-based clustering

Le, Q. K.; Angel, E.; Tahi, F.; Postic, G.

10.1101/2025.01.12.632579 — bioinformatics — Posted on 2025-05-14

3510 CONVEX: Consensus Variant Pipeline for Exome Analysis

Raju, R. M.; Singh, U. P.; Suravajhala, P.

10.1101/2023.10.07.561328 — bioinformatics — Posted on 2025-05-14

3511 Generative AI-driven artificial DNA design for enhancing inter-species gene activation and enzymatic degradation of PET

Akiyama, M.; Tashiro, M.; Huang, Y.; Uehara, M.; Kanzaki, T.; Itaya, M.; Kataoka, M.; Miyamoto, K.; Sakakibara, Y.

10.1101/2025.05.08.652991 — bioinformatics — Posted on 2025-05-14

3512 A Phantom for Fluorescence Uniformity and Distortion Assessment of Near-Infrared Fluorescence Guided Surgery Systems

Mannoh, E.; Robledo, E. A.; Streeter, S. S.; LaRochelle, E. P. M.; Ruiz, A. J.

10.1101/2025.05.08.652975 — bioengineering — Posted on 2025-05-14

3513 Vib2Sound: Separation of Multimodal Sound Sources

Akahoshi, M.; Wang, Y.; Cheng, L.; Zai, A. T.; Hahnloser, R. R. H.

10.1101/2025.05.08.652866 — animal behavior and cognition — Posted on 2025-05-14

3514 Resources for molecular studies of unculturable obligate biotrophic fungal plant pathogens using their saprotrophic relatives

Loos, A.; Doykova, E.; Qian, J.; Kümmel, F.; Ibrahim, H.; Kiss, L.; Panstruga, R.; Kusch, S.

10.1101/2025.05.08.652889 — genomics — Posted on 2025-05-14

3515 Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions

Williams, H. M.; Watson, A.; Madsen, J.; Clark, H. W.; Hood, D. W.; Oscarson, S.; Greenhough, T. J.; Shrive, A. K.

10.1101/2025.05.08.652840 — immunology — Posted on 2025-05-14

3516 ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes

Nikopaschou, M.; Samiotaki, M.; Kannavou, A.; Angelis, N.; Tsitsilonis, O.; Panayotou, G.; Stratikos, E.

10.1101/2025.05.08.652898 — immunology — Posted on 2025-05-14

3517 Ultradeep N-glycoproteome Atlas of Mouse Reveals Spatiotemporal Signatures of Brain Aging and Neurodegenerative Diseases

Fang, P.; Yu, X.; ding, m.; Cong, Q.; Jiang, H.; Shi, Q.; Zhao, W.; Zheng, W.; Li, Y.; Ling, Z.; Kong, W.; Yang, P.; Shen, H.

10.1101/2025.02.15.638397 — neuroscience — Posted on 2025-05-14

3518 Low-Intensity Ultrasound Stimulates TAZ in Schwann cells

Acheta, J.; Haley, J.; Mondschein, A. S.; Lanka, M.; Belin, S.; Poitelon, y.

10.1101/2025.05.08.652925 — neuroscience — Posted on 2025-05-14

3519 Molecular pathology of acute spinal cord injury in middle-aged mice

Fehlberg, C.; John, D.; Kang, B.; Choi, J. S.; Cerqueira, S. R.; Brake, A.; Lee, J. K.

10.1101/2025.05.08.652873 — neuroscience — Posted on 2025-05-14

3520 Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury

Reid, S. K.; Tran, A. V.; Leal-Garcia, M. E.; Devaraj, S.; Ozturgut, M.; McCreedy, D. A.

10.1101/2025.05.08.652924 — neuroscience — Posted on 2025-05-14

3521 Normative Brain Entropy Across the Lifespan

Del Mauro, G.; Zeng, X.; Wang, Z.

10.1101/2025.05.08.652915 — neuroscience — Posted on 2025-05-14

3522 Unbiased genetics identifies a glutamatergic signaling network as a mediator of daily sleep patterns.

Grizzard, S.; Lord, J. S.; Ravens, A. L.; Hao, Y.; Tang, W.; Lee, S. H.; Sleiman, S. J.; Joyce, K. K.; Donohue, K. D.; O'Hara, B. F.; Zou, F.; Kafri, T.; Diering, G. H.

10.1101/2025.05.08.652901 — neuroscience — Posted on 2025-05-14

3523 Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease

van der Vliet, D.; de Vries, L. E.; Di, X.; de Jong, B.; van der Meij, M. T. C.; van der Peet, M.; Harms, A. C.; Hankemeier, T.; Swaab, D. F.; Huitinga, I.; Verhaagen, J.; van der Stelt, M.

10.1101/2025.05.08.652735 — neuroscience — Posted on 2025-05-14

3524 Eccentric cycling improves motor learning more than concentric cycling

Youssef, L.; Pageaux, B.; Neva, J. L.

10.1101/2025.05.08.652761 — neuroscience — Posted on 2025-05-14

3525 Elusive scent of fear: no evidence of olfactory reversal conditioning in humans

Menger, N. S.; Kotchoubey, B.; Pavlov, Y. G.

10.1101/2025.05.08.652858 — neuroscience — Posted on 2025-05-14

3526 FLP-15 modulates the amplitude of body bends during locomotion in Caenorhabditis elegans

Bhat, U. S.; H, S.; Surendran, S.; Tasnim, N.; Babu, K.

10.1101/2025.05.08.652979 — neuroscience — Posted on 2025-05-14

3527 CMiNet: An R Package and User-Friendly Shiny App for Constructing Consensus Microbiome Networks

Aghdam, R.; Solis-Lemus, C.

10.1101/2025.05.09.653200 — systems biology — Posted on 2025-05-14

3528 Experimental flooding impacts soil biogeochemistry but not aboveground vegetation in a coastal forest

Regier, P.; Bond-Lamberty, B.; Ward, N. D.; Bailey, V.; Bittencourt Peixoto, R.; Machado-Silva, F.; McDowell, N.; Morris, K.; Myers-Pigg, A.; Pennington, S.; Rahman, M.; Rich, R.; Smith, R.; Wilson, S. J.; Woodard, S.; Stearns, A.; Day, D.; Doro, K. O.; Emmanuel, E.; Ogunsola, O.; Patel, K.; Megonigal, J. P.

10.1101/2025.05.09.653188 — systems biology — Posted on 2025-05-14

3529 Smooth muscle LRRC8A knockout preserves vascular function in AngII hypertension

Choi, H.; Panja, S.; Nguyen, H.-N.; Stark, R. J.; Lamb, F. S.

10.1101/2025.05.08.652978 — physiology — Posted on 2025-05-14

3530 Longitudinal study of liver disease progression in the PEX1-Gly844Asp mouse model of mild Zellweger Spectrum Disorder

Chen, L.; Choi, H.; Argyriou, C.; Hsieh, M.; Di Pietro, E.; Cui, W.; Nuebel, E.; Daneault, C.; Ruiz, M.; Charpentier, D.; Rhainds, D.; Hacia, J. G.; Nguyen, V.-H.; Gao, Z.; Braverman, N.

10.1101/2025.05.08.652960 — pathology — Posted on 2025-05-14

3531 Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis

Wu, S.; Driver, I.; Luo, M.; Miyazaki, H.; Shambhu, S.; Popov, D.; Yang, L.; Wang, J.; Ma, J.; Guo, J.; Atha, J.; Tata, A.; Hoffman, E.; Wang, Y.; Tata, P.; Jensen, M. B.; Engelhardt, J. F.; Sontake, V.; Liu, X.

10.1101/2025.05.08.652970 — pathology — Posted on 2025-05-14

3532 LivecellX: A Deep-learning-based, Single-Cell Object-Oriented Framework for Quantitative Analysis in Live-Cell Imaging

Ni, K.; Yu, G.; Zheng, Z.; Lu, Y.; Poe, D.; Zhang, S.; Wang, Z.; Khurana, Y.; Lu, Y.; Chen, Y.; Zhou, S.; Sanborn, M.; Wang, W.; Xing, J.

10.1101/2025.02.23.639532 — biophysics — Posted on 2025-05-14

3533 DynaMiCs - Dynamic cell-type deconvolution ensembles for Mapping in mixed Conditions

Seifert, N.; Engel, L.; Tauschke, J.; Sterr, T.; Demmer, J.; Mensching-Buhr, M.; Voelkl, D.; Grellscheid, S. N.; Beissbarth, T.; Goertler, F.; Zacharias, H.; Altenbuchinger, M.

10.1101/2025.05.08.652868 — bioinformatics — Posted on 2025-05-14

3534 Mapping the Structural Landscape of Amyloid Fibrils to Guide Polymorph-Specific Therapeutics

Sadek, A.; Correia, B. E.; Lashuel, H. A.

10.1101/2025.05.08.652887 — bioinformatics — Posted on 2025-05-14

3535 Identification and In Silico Characterization of Novel lncRNAs Associated with Dengue Infection

Pandey, A. D.; Kuldeep, J.; Vrati, S.; Banerjee, A.

10.1101/2025.05.08.652916 — bioinformatics — Posted on 2025-05-14

3536 Discovering disease genetic variation impacting gene expression in 103 brain tissues with the Brain Ontology Expression (BRONTE) graph neural network model

Ke, J.; Ge, T.; Melamed, R. D.

10.1101/2025.05.08.652857 — bioinformatics — Posted on 2025-05-14

3537 Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge

Zhang, Z.; Bao, X.; Jiang, L.; Luo, X.; Wang, Y.; Comai, A.; Waldhaus, J.; Hansen, A. S.; Li, W.; Liu, J.

10.1101/2025.05.08.652986 — bioinformatics — Posted on 2025-05-14

3538 Click chemistry-based quantification of extracellular matrix turnover for drug screening and regenerative medicine

Porter, A.; Fan, S.; Peng, Y.; Lv, M.; Zhou, Y.; Alanazi, A.; Han, L.; Wang, L.; Lu, X. L.

10.1101/2025.05.08.652928 — bioengineering — Posted on 2025-05-14

3539 Venom vesicles from the parasitoid Ganaspis hookeri facilitate venom protein entry into host immune cells

Bretz, N. M.; Lark, C.; Perkel, S.; Jackson, R.; Driskell, J. D.; Mobley, J. A.; Mortimer, N. T.

10.1101/2025.05.08.652939 — biochemistry — Posted on 2025-05-14

3540 Population genetics of the endangered narrowly endemic Island Marble butterfly (Euchloe ausonides insulanus)

Jones, K. S.; Aunins, A. W.; Young, C. C.; Johnson, R. L.; Morrison, C. L.

10.1101/2025.05.08.652852 — genetics — Posted on 2025-05-14

3541 Pnrc2 promotes rapid mRNA decay and coordinately supports early development with P-body factors Ddx6 and Ddx61

Gallagher, T. L.; Blatnik, M. C.; Austin, C. C.; Thompson, K. G.; Pvirre, D. M.; Morgan, A.; Kearse, M. G.; Amacher, S. L.

10.1101/2025.05.08.652725 — developmental biology — Posted on 2025-05-14

3542 Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

Islam, F.; Williams, C.; Boal-Carvalho, I.; Seddon, B.

10.1101/2025.05.08.652875 — immunology — Posted on 2025-05-14

3543 Evaluation of epistasis detection methods for quantitative phenotypes

Listopad, S.; Peng, Q.; Renjith, G.

10.1101/2025.04.30.651312 — bioinformatics — Posted on 2025-05-14

3544 AI4CellFate: Interpretable Early Cell Fate Prediction with Generative AI

Cunha, I.; Panconi, L.; Bauer, S.; Gestin, M.; Latron, E.; Sahai, E.; Le Marois, A.; Griffie, J.

10.1101/2025.05.12.653464 — bioinformatics — Posted on 2025-05-14

3545 Genetic basis of immunity in Indian cattle as revealed by comparative analysis of Bos genome

Thambiraja, M.; Iyengar, S. K.; Sathishkumar, B.; Kavuru, S. R.; Katari, A.; Singh, D.; Onteru, S. K.; Yennamalli, R. M.

10.1101/2024.12.09.627532 — bioinformatics — Posted on 2025-05-14

3546 Molecular phylogenetics illuminates the evolutionary history and hidden diversity of Australian cave crickets (Orthoptera: Rhaphidophoridae)

Beasley-Hall, P. G.; Trewick, S. A.; Eberhard, S. M.; Zwick, A.; Reed, E. H.; Cooper, S. J. B.; Austin, A. D.

10.1101/2024.08.11.607522 — evolutionary biology — Posted on 2025-05-14

3547 Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells

Banerjee, S.; Shende, S.; Kata, L.; Lopes, R.; Praveen, S.; Joshi, R.; Khare, N. K.; Raghuram, G. V.; Shabrish, S.; Mittra, I.

10.1101/2023.11.21.567988 — evolutionary biology — Posted on 2025-05-14

3548 Host genotype and sex shape influenza evolution and defective viral genomes

Costa, R. M.; Alvarez-Acosta, L.; Curtis, K.; Kelleher, J.; Lamichhane, B. S.; Valesano, A. L.; Fitzsimmons, W. J.; Lauring, A. S.; Seger, J.; Adler, F. R.; Potts, W. K.

10.1101/2025.02.26.638946 — evolutionary biology — Posted on 2025-05-14

3549 Emergent loss of microbial biodiversity with increasing resource diversity

Shalev, O.; Ye, X.; Kilian, J.; Stahl, M.; Ratzke, C.

10.1101/2025.05.13.653732 — microbiology — Posted on 2025-05-14

3550 Siderophores can alter the population dynamics of fungal-bacterial communities by inhibiting specialized metabolism

Pham, H. T.; Kim, W.; Jang, J.; Kim, J. S.; Lim, Y. W.; Kovacs, A. T.; Kang, K. B.

10.1101/2025.05.12.653243 — microbiology — Posted on 2025-05-14

3551 Salmonella relies on siderophore exploitation at low pH

Ferry, M.; Sharp, C.; Schalk, I. J.; Cunrath, O.

10.1101/2025.05.06.652355 — microbiology — Posted on 2025-05-14

3552 A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

Rühling, M.; Schmelz, F.; Ulbrich, K.; Schumacher, F.; Wolf, J.; Pfefferle, M.; Priester, M.; Moldovan, A.; Knoch, N.; Iwanowitsch, A.; Kappe, C.; Paprotka, K.; Kleuser, B.; Arenz, C.; Fraunholz, M. J.

10.1101/2024.09.13.612871 — microbiology — Posted on 2025-05-14

3553 Tissue-specific improvements in CD4+ T cell responses after treatment for visceral leishmaniasis.

Engel, J. A.; Rivera, F.; Crawford, B.; Lee, H. J.; Na, J.; Chang, K.; Gartlan, K.; Bukali, L.; Frame, T.; Wang, Y.; Haque, A.; Engwerda, C.; Engwerda, C.

10.1101/2025.04.13.648617 — immunology — Posted on 2025-05-14

3554 Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.

CHIE, J. A. K. H. C.; PERSOHN, S. A.; PANDEY, R. S.; SIMCOX, O. R.; SALAMA, P.; TERRITO, P. R.

10.1101/2025.05.12.653558 — neuroscience — Posted on 2025-05-14

3555 Visual adaptation stronger at horizontal than vertical meridian: Linking performance with V1 cortical surface area

Lee, H.-H.; Carrasco, M.

10.1101/2025.03.07.642102 — neuroscience — Posted on 2025-05-14

3556 Minimally invasive activation of spared interneurons alleviates local CA1 hypersynchrony and behavioral deficits in a model of temporal lobe epilepsy

Matringhen, C.; Vigier, A.; Michel, F. J.; Bourtouli, N.; Marissal, T.

10.1101/2024.08.02.606307 — neuroscience — Posted on 2025-05-14

3557 Frontal Theta Oscillations and Cognitive Flexibility: Age-Related Modulations in EEG Activity

Darna, M.; Stolz, C.; Jauch, H. S.; Strumpf, H.; Hopf, J. M.; Seidenbecher, C. I.; Schott, B. H.; Richter, A.

10.1101/2024.07.05.602082 — neuroscience — Posted on 2025-05-14

3558 Why is there so much variability in crop multi-model studies?

Wallach, D.; Palosuo, T.; Mielenz, H.; Buis, S.; Thorburn, P.; Asseng, S.; Dumont, B.; Ferrise, R.; Gayler, S.; Ghahramani, A.; Harrison, M. T.; Hochman, Z.; Hoogenboom, G.; Huang, M.; Jing, Q.; Justes, E.; Kersebaum, K. C.; Launay, M.; Lewan, E.; Liu, K.; Luo, Q.; Mequanint, F.; Nendel, C.; Padovan, G.; Olesen, J. E.; Pullens, J. W. M.; Qian, B.; Seserman, D.-M.; Shelia, V.; Souissi, A.; Specka, X.; Wang, J.; Weber, T. K. D.; Weihermuller, L.; Seidel, S.

10.1101/2023.02.03.526931 — plant biology — Posted on 2025-05-14

3559 Large Language Models Can Extract Metadata for Annotation of Human Neuroimaging Publications

Turner, M. D.; Appaji, A.; Ar Rakib, N.; Golnari, P.; Rajasekar, A. K.; Rathnam K V, A.; Sahoo, S. S.; Wang, Y.; Wang, L.; Turner, J. A.

10.1101/2025.05.13.653828 — bioinformatics — Posted on 2025-05-14

3560 Beyond the Leaderboard: Leveraging Predictive Modeling for Protein-Ligand Insights and Discovery

Kalifa, D.; Radinsky, K.; Horvitz, E.

10.1101/2025.05.12.653449 — bioinformatics — Posted on 2025-05-14

3561 Novel features of miRNA and isomiR-mRNA interactions

Weston, M.; Ripan, R. C.; Li, X.; Hu, H.

10.1101/2025.05.12.653582 — bioinformatics — Posted on 2025-05-14

3562 DNA-methylation markers associated with lung function at birth and childhood reveal early life programming of inflammatory pathways

Kachroo, P.; Shutta, K. H.; Maiorino, E.; Moll, M.; Hecker, J.; Carey, V. J.; McGeachie, M. J.; Litonjua, A. A.; Celedon, J. C.; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, ; Weiss, S. T.; DeMeo, D. L.

10.1101/2025.05.12.653131 — genomics — Posted on 2025-05-14

3563 A phased chromosome-level genome resource for a myrtle rust susceptible Syzygium luehmannii

Tobias, P.; Downs, J.; Martino, A. M.; Edwards, R. J.

10.1101/2025.05.12.653576 — genomics — Posted on 2025-05-14

3564 Randomized field trial of a therapeutic vaccine against Trypanosoma cruzi natural infection in dogs and correlates for efficacy

Calderon-Quintal, J. A.; Teh-Poot, C.; Piste, L. M. P.; Martinez-Vega, P. P.; Dzul-Huchim, V.; Torres-Acosta, F.; Waleckx, E.; Villanueva-Lizama, L. E.; Ortega-Lopez, J.; Herrera, C.; Dumonteil, E.; Cruz-Chan, J. V.

10.1101/2025.05.12.653529 — microbiology — Posted on 2025-05-14

3565 Development of a cross-protective common cold coronavirus vaccine

Penaloza-MacMaster, P.; Dangi, T.; Li, S.

10.1101/2025.05.12.653567 — immunology — Posted on 2025-05-14

3566 Opposing Modulation of EEG Aperiodic Component by Ketamine and Thiopental: Implications for the Noninvasive Assessment of Cortical E/I Balance in Humans

Cortes-Briones, J.; Urrutia-Gandolfo, J.; Estevez, P.; Sengupta, A.; Basilico, M.; Skosnik, P.; Limoncelli, D.; D'Souza, D. C.; Petrakis, I.; Krystal, J.

10.1101/2025.05.12.653580 — neuroscience — Posted on 2025-05-14

3567 Cerebral plasticity after hypoglosso-facial anastomosis in facial palsy: a magnetoencephalography study

HERVOCHON, R.

10.1101/2025.05.13.652175 — neuroscience — Posted on 2025-05-14

3568 How bibliometric analysis can help to specify and track interdisciplinary research areas: A term-based analysis approach

Streeb, T.; Schreyvogel, C.; Jehle, C.; Rensing, S. A.

10.1101/2025.05.12.653370 — scientific communication and education — Posted on 2025-05-14

3569 Estimating the additive genetic variance for relative fitness from changes in allele frequency

Geeta Arun, M.; Angus-Henry, A.; Obbard, D. J.; Hadfield, J. D.

10.1101/2025.05.13.653886 — evolutionary biology — Posted on 2025-05-13

3570 The evolution of gene functional repertoire in Amorphea: Divergent strategies across Amoebozoa, Fungi, and Metazoa.

Galvez-Morante, A.; Berney, C.; Richter, D. J.

10.1101/2025.05.13.653667 — evolutionary biology — Posted on 2025-05-14

3571 A novel non-catalytic function of PA2803-encoded PcrP contributes to polymyxin B resistance in P. aeruginosa and redefines the functional role of the PA2803 subfamily.

Salpadoru, T.; Khanam, S. S.; Borin, V.; Achour, M.; Oh, D.; Kanik, M.; Gallage, P.; Khanov, A.; Hull, M.; Pitre, S.; Agarwal, P. K.; Franklin, M. J.; Patrauchan, M. A.

10.1101/2025.05.13.653872 — microbiology — Posted on 2025-05-13

3572 Spontaneous spiking statistics form unique area-specific fingerprints and reflect the hierarchy of cerebral cortex

Morales-Gregorio, A.; Gutzen, R.; Paneri, S.; Sapountzis, P.; Kleinjohann, A.; Grün, S.; Riehle, A.; Chen, X.; Brochier, T.; Gregoriou, G. G.; Kilavik, B. E.; van Albada, S. J.

10.1101/2025.05.13.653871 — neuroscience — Posted on 2025-05-13

3573 Diverse activity in prefrontal projections promotes temporal control of action

Ding, X.; Weber, M. A.; Butler, T.; Bova, A. S.; Guerrero, S.; Hunter, C.; Cole, R. C.; Stutt, H. R.; McMurrin, M. A.; Spicer, M.; Conlon, M. M.; Heiney, S. I.; Resch, J. M.; Narayanan, N. S.

10.1101/2025.05.12.653607 — neuroscience — Posted on 2025-05-13

3574 Alpha power indexes working memory load for durations

Herbst, S. K.; Mangione, I.; Segerie, C. R.; Hoechenberger, R.; Kononowicz, T. W.; Gramfort, A.; van Wassenhove, V.

10.1101/2025.05.12.653390 — neuroscience — Posted on 2025-05-13

3575 Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex

Bowler, J. C.; Azhar, D.; Jensen, C. M.; Lee, H.-W.; Heys, J. G.

10.1101/2025.05.13.653873 — neuroscience — Posted on 2025-05-13

3576 Assessing genomic reproducibility of read alignment tools

Baykal, P. I.; Simonov, M.; Deshpande, D.; Korukoglu, F. B.; Moore, J.; Chhugani, K.; Liu, C.; Sarwal, V.; Rajkumar, N.; Alser, M.; Beerenwinkel, N.; Mangul, S.

10.1101/2025.05.08.652934 — bioinformatics — Posted on 2025-05-13

3577 RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood

Navarro-Delgado, E. I.; Czamara, D.; Edwards, K.; Fu, M. P.; Merrill, S. M.; Konwar, C.; MacIsaac, J. L.; Lin, D. T.; Mandhane, P. J.; Simons, E.; Subbarao, P.; Moraes, T. J.; Lahti, J.; Miller, G. E.; Binder, E. B.; Räikkönen, K.; Turvey, S.; Korthauer, K.; Kobor, M. S.

10.1101/2025.05.08.652964 — bioinformatics — Posted on 2025-05-13

3578 Automating AI Discovery for Biomedicine Through Knowledge Graphs And LLM Agents

Aamer, N.; Asim, M. N.; Munir, S.; Dengel, A.

10.1101/2025.05.08.652829 — bioinformatics — Posted on 2025-05-13

3579 Deep Volumetric Localization Super-Resolution Microscopy

Han, K.; Hua, X.; Qi, T.; Gao, Z.; Wang, X.; Jia, S.

10.1101/2025.05.08.652845 — bioengineering — Posted on 2025-05-13

3580 Interaction of Ricin and RCA-I lectin with Human Serum Glycoproteins and Lung Cells

Vanderpuye, O. A.; Smith, J. A.

10.1101/2025.05.08.652972 — biochemistry — Posted on 2025-05-13

3581 The distribution of fitness effects varies phylogenetically across animals

Lin, M.; Chakraborty, S.; Amorim, C. E. G.; Morales, S. N.; Beichman, A. C.; Nunez-Valencia, P. G.; Mah, J. C.; Ronbinson, J. A.; Kyriazis, C. C.; Huber, C. D.; Webb, A. E.; Kocher, S. D.; Archer, F. I.; Moreno-Estrada, A.; Wayne, R. K.; Lohmueller, K. E.

10.1101/2025.05.13.653358 — evolutionary biology — Posted on 2025-05-13

3582 Evolutionary trajectories of cohesin gatekeepers across the Tree of Life

Quiroz, D.; Pierce, A.; Monroe, J. G.

10.1101/2025.05.08.652912 — evolutionary biology — Posted on 2025-05-13

3583 Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.

Misner, R.; Reilein, A.; Kalderon, D.

10.1101/2025.05.08.652870 — developmental biology — Posted on 2025-05-13

3584 Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution

Tulloch, A. J.; Delgado, R. N.; Catta-Preta, R.; Cepko, C. L.

10.1101/2025.05.13.653746 — developmental biology — Posted on 2025-05-13

3585 Optimizing brinjal (Solanum melongena L.) health and yield through bio-organic amendments against Fusarium wilt

Mauya, J.; Akhter, K.; Mim, H. K.; Rahman, M.; Ferdous, R.

10.1101/2025.05.13.653889 — microbiology — Posted on 2025-05-13

3586 Genomic differentiation of Mannheimia haemolytica genotypes

Deschner, D.; Hill, J. E.

10.1101/2025.05.13.653884 — microbiology — Posted on 2025-05-13

3587 Inhibitory TIGIT signalling is dependent on T cell receptor activation

Zammit, W. H.; Le Maistre, L.; Elliot, T. A. E.; Cain, S. A.; Humphries, M. J.; Davis, D. M.; Worboys, J. D.

10.1101/2025.05.08.652881 — immunology — Posted on 2025-05-13

3588 Neuropeptidergic transmission shapes emergent properties of prefrontal cortical circuits underlying learning

Arenivar, M. A.; Ross, N.; Flores, R. J.; Zakariya, S.; Wang, Z. Z.; Yarur, H. E.; Kore, R.; Richiez-Mateo, W. V.; Limoges, A.; Wang, H.; Bravo-Rivera, H.; Agbor-Enoh, D.; Enriquez-Traba, J.; Gu, X.; Averbeck, B.; Li, Y.; Tejeda, H.

10.1101/2025.05.13.653840 — neuroscience — Posted on 2025-05-13

3589 Using Constraint-Based Metabolic Modeling to Elucidate Drug-Induced Metabolic Changes in a Cancer Cell Line

Benedicto, X.; Flobak, A.; Ponce de Leon, M.; Valencia, A.

10.1101/2025.05.08.652850 — systems biology — Posted on 2025-05-13

3590 Magnetically controlled tension of cytoskeletal elements with magnetic nanoparticles affects the expression of signaling pathway genes associated with cytoskeletal elements

Pozdina, V.; Karavashkova, O.; Minin, A. S.; Zubarev, I.

10.1101/2025.05.08.652598 — bioinformatics — Posted on 2025-05-13

3591 POPARI: Modeling multisample variation in spatial transcriptomics

Alam, S.; Zhou, T.; Haber, E.; Chidester, B.; Liu, S.; Chen, F.; Ma, J.

10.1101/2025.05.08.652741 — bioinformatics — Posted on 2025-05-13

3592 Toward Reliable Synthetic Omics: Statistical Distances for Generative Models Evaluation

Marchesi, R.; Lazzaro, N.; Leonardi, G.; Rignanese, F.; Bovo, S.; Chierici, M.; Jurman, G.

10.1101/2025.05.08.652855 — bioinformatics — Posted on 2025-05-13

3593 Chemical Environment of the Confinement Governs Thermal Stability of the Folded Telomere G-Quadruplex

Majumdar, T.; Bisoi, A.; Singh, P. C.

10.1101/2025.05.08.652821 — biochemistry — Posted on 2025-05-13

3594 New gene annotations for three pea aphid genome assemblies allow comparative analyses of genes and gene family evolution

Deem, K. D.; Brisson, J. A.

10.1101/2025.05.08.652899 — genomics — Posted on 2025-05-13

3595 Development of an open-pollinated genetic mapping framework to facilitate the identification of QTL in apples

Hickok, D.; Khan, A.; Robbins, K.

10.1101/2025.05.08.652880 — genetics — Posted on 2025-05-13

3596 Why are telomeres the length that they are? Insight from a phylogenetic comparative analysis

Benson, D. M.; Padilla, D. J.; DENARDO, D.

10.1101/2024.09.25.613781 — evolutionary biology — Posted on 2025-05-13

3597 Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species

Xu, L.; Shen, S.; Zhang, Y.; Guo, Z.; Lu, B.; Huang, J.; Li, R.; Shen, Y.; Zhang, L.; Deng, X.

10.1101/2025.05.13.653745 — microbiology — Posted on 2025-05-13

3598 Targeted loss of heterozygosity in Candida albicans using CRISPR-Cas9

Despres, P. C.; Gervais, N. C.; Fogal, M.; Rogers, R. K.; Cuomo, C. A.; Shapiro, R. S.

10.1101/2025.05.13.653461 — microbiology — Posted on 2025-05-13

3599 A remarkable expansion of secreted cysteine knot proteins reveals novel virulence factors in the human fungal pathogen Histoplasma

Rodriguez, R. A.; Azimova, D.; Voorhies, M.; English, B. C.; Symington, J.; Sil, A.

10.1101/2025.05.13.653811 — microbiology — Posted on 2025-05-13

3600 Unexpected variability in laboratory and clinical assays used to quantify Cryptococcus neoformans polysaccharide.

Wear, M. P.; Kim, D.; Roy, R.; Casadevall, A.

10.1101/2025.05.13.653753 — microbiology — Posted on 2025-05-13

3601 An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

Henshall, I. G.; Chmielewski, J.; Angange, D.; Romeo, O.; Lai, K. H.; Turland, K. R.; Badii, N.; Foley, M.; Anders, R. F.; Beeson, J.; Wilson, D. W.

10.1101/2025.05.13.653866 — microbiology — Posted on 2025-05-13

3602 Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.

Howard, M.; Farrar, C. A.; Nauser, C.; Jeon, Y.; Polycarpou, A.; Smolarek, D.; Greenlaw, R.; Garred, P.; Alexandra, D.; Mukhopadhyay, S.; Sacks, S.

10.1101/2025.05.08.652605 — immunology — Posted on 2025-05-13

3603 Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma

Rahimi, R. A.; Smith, N. P.; Selle, A.; Best, R.; Martin, S.; Tuttle, E.; Ling, M. F.; Medoff, B.; Villani, A.-C.; Luster, A. D.

10.1101/2025.05.08.652962 — immunology — Posted on 2025-05-13

3604 Acetaminophen attenuates pathological pain through a mechanism that requires CB1 cannabinoid receptors and the enzyme diacylglycerol lipase in mice

Jesus, C. A.; Wirt, J. L.; Ferreira, L. A.; Hainline, J.; Huizenga, M.; Rems, L.; Makriyannis, A.; van der Stelt, M.; Hohmann, A. G.

10.1101/2025.05.08.652937 — neuroscience — Posted on 2025-05-13

3605 Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

Arecchi, G.; Dente, M.; Ma, W.; Scellini, B.; Piroddi, N.; Scardigli, M.; Yu, J.; Zhao, J.; Cicchi, R.; Kinegawa, R.; Muellenbroich, C.; Poggesi, C.; Ferrantini, C.; Irving, T.; Regnier, M.; Sacconi, L.; Tesi, C.

10.1101/2025.05.08.652664 — physiology — Posted on 2025-05-13

3606 The mouse pangenome reveals the structural complexity of the murine protein coding landscape

10.1101/2025.05.13.653481 — genomics — Posted on 2025-05-13

3607 Taxonomy-driven variations in snow algae color modulate albedo and energy balance in a single snow patch

Almela, P.; Elser, J. J.; Zmuda, A.; Niehaus, T.; Hamilton, T. L.

10.1101/2025.05.13.653574 — microbiology — Posted on 2025-05-13

3608 Molecular insights into nucleocapsid assembly and transport in Marburg and Ebola viruses

Takamatsu, Y.; Dolnik, O.; Hirabayashi, A.; Okamoto, K.; Kurashige, T.; Hu, S.; Oda, C. H.; Noda, T.

10.1101/2025.05.13.653679 — microbiology — Posted on 2025-05-13

3609 Investigating Bacterial Contributions to Thermal Tolerance in Three Intertidal Marine Snail Tegula species

Applegate, B.; Burkhart, M.; Caddow, H.; Gover, B.; Kantola, M.-F.; Obenchain, J. G.; Smith, A.; Nash, B.; Enke, R. A.; Gleason, L. U.

10.1101/2025.05.13.653156 — microbiology — Posted on 2025-05-13

3610 Siderophores can alter the population dynamics of fungal-bacterial communities by inhibiting specialized metabolism

Pham, H. T.; Kim, W.; Jang, J.; Kim, J. S.; Lim, Y. W.; Kovacs, A. T.; Kang, K. B.

10.1101/2025.05.12.653243 — microbiology — Posted on 2025-05-13

3611 LicD-Mediated Cell Wall Decoration Governs Phage Sensitivity in Enterococcus faecalis Clinical Isolates

Awad, M.; Bouras, G.; Feizi, S.; Grigson, S. R.; Wormald, P.-J.; Psaltis, A. J.; Vreugde, S.

10.1101/2025.05.13.653012 — microbiology — Posted on 2025-05-13

3612 Leaf Mold Agar Facilitates Recovery of Soil Bacterial Diversity Beyond Bacillus Dominance

Tabuchi, F.; Mikami, K.; Ishii, M.; Yasukawa, J.; Miyauchi, M.; Silva, D. P. N. d.; Miyashita, A.

10.1101/2025.05.13.653698 — microbiology — Posted on 2025-05-13

3613 Co-infection with Streptococcus and Rothia spp. drives prophage dynamics in Pseudomonas aeruginosa in an artificial sputum model

Wright, L. L.; Cazares, A.; Figueroa, W.; Chatterley, L. C.; Willmott, T. O.; O'Brien, S.; Fothergill, J.

10.1101/2025.05.13.653867 — microbiology — Posted on 2025-05-13

3614 Emergent loss of microbial biodiversity with increasing resource diversity

Ratzke, C.; Shalev, O.; Ye, X.; Kilian, J.; Stahl, M.

10.1101/2025.05.13.653732 — microbiology — Posted on 2025-05-13

3615 Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

Li, D.; Zheng, H.; Bai, Y.; Zhang, Z.; Cheng, H.; Huang, X.; Wei, T.; Zaritsky, A.; Hwa, T.; Liu, C.

10.1101/2025.05.13.653648 — microbiology — Posted on 2025-05-13

3616 Design and development of lysyl tRNA synthetase inhibitors, for the treatment of tuberculosis

Davis, S. H.; Mathieson, M.; Buchanan, K. I.; Dawson, A.; Smith, A.; Cocco, M.; Tamaki, F. K.; Post, J.; Baragana, B.; Jansen, C.; Kiczun, M.; Zuccotto, F.; Wood, G.; Scullion, P.; Ray, P. C.; Epemolu, O.; Lopez-Roman, E. M.; Guijarro Lopez, L.; Engelhart, C. A.; Kim, J.; Pino, P. A.; Schnappinger, D.; Read, K. D.; Encinas, L.; Bates, R. H.; Wyatt, P. G.; Green, S. R.; Cleghorn, L. A.

10.1101/2025.05.13.646596 — microbiology — Posted on 2025-05-13

3617 Proteolytic Activity and Substrate Specificity of Lake Geneva

Meibom, J.; Wichmann, N.; Zumstein, M.; Kohn, T.

10.1101/2025.05.13.653673 — microbiology — Posted on 2025-05-13

3618 A compact viral IRES translates a downstream open reading frame

Sherlock, M. E.; Segar, K. E.; Kieft, J. S.

10.1101/2025.05.13.653779 — microbiology — Posted on 2025-05-13

3619 Viral silencing suppressor activity in plants modifies aphid antiviral immunity and fecundity

Preising, S. E.; Wilson, J. R.; Parker, G. M.; DeBlasio, S. L.; Reeve, D.; Chappie, J. S.; Heck, M. L.

10.1101/2025.05.13.653761 — microbiology — Posted on 2025-05-13

3620 Single-Stranded nucleic acid binding enhances the in vitro catalytic activity of Chikungunya virus nsP2 protease

Mastalipour, M.; Coronado, M. A.; Siahaan, R. A.; Drees, A.; Ahlers, C.; Fischer, M.; Willbold, D.; Eberle, R. J.

10.1101/2025.05.13.653680 — biochemistry — Posted on 2025-05-13

3621 Long range mutual activation establishes Rho and Rac polarity during cell migration

De Belly, H.; Gallen, A. F.; Strickland, E.; Estrada, D. C.; Zager, P. J.; Nagy, T. L.; Burkhardt, J. K.; Turlier, H.; Weiner, O.

10.1101/2024.10.01.616161 — cell biology — Posted on 2025-05-13

3622 Structural basis of RNA polymerase II transcription on the H3-H4 octasome

Ho, C.-H.; Nozawa, K.; Nishimura, M.; Oi, M.; Kujirai, T.; Ogasawara, M.; Ehara, H.; Sekine, S.-i.; Takizawa, Y.; Kurumizaka, H.

10.1101/2025.05.13.653634 — molecular biology — Posted on 2025-05-13

3623 A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants

Ma, Y.; Ye, C.; Khalil, A. M.; Mahmoud, S. H.; Sobolik, E. B.; Greninger, A. L.; Castro, E.; Jackson, N.; Bayoumi, M.; Plemper, R. K.; Martinez-Sobrido, L.

10.1101/2025.05.09.653029 — microbiology — Posted on 2025-05-13

3624 Intracellular and extracellular dynamics of herpes simplex virus 1 DNA and infectious particles in epithelial and neuronal cells

Esmaeili, S.; Swan, D. A.; Jerome, K. R.; Schiffer, J. T.; Walter, M.

10.1101/2025.05.13.653775 — microbiology — Posted on 2025-05-13

3625 Mycobacterium tuberculosis MutT4 is an RNA pyrophosphohydrolase that forms biomolecular condensates and sensitizes mRNAs to degradation

Cafiero, J. H.; Xiao, J.; Lepori, I.; Rapiejko, A. R.; Reddy, M.; Roberts, L.; Siegrist, M. S.; Sacchettini, J. C.; Shell, S. S.

10.1101/2025.05.13.653832 — microbiology — Posted on 2025-05-13

3626 Conditional filamentation enhances bacterial survival in toxic environments

Aguilar Luviano, O. B.; Santos-Escobar, F.; Orozco-Barrera, S.; Pena-Miller, R.

10.1101/2025.05.13.653778 — microbiology — Posted on 2025-05-13

3627 Temperate phages increase antibiotic effectiveness in a Caenorhabditis elegans infection model

Fatima, R.; MacNeil, L. T.; Hynes, A. P.

10.1101/2024.10.28.620739 — microbiology — Posted on 2025-05-13

3628 Non-redundant cardiolipin synthases support membrane integrity and stress resilience in Bacteroides fragilis

Schnizlein, M. K.; Hong, B. J.; Nguyen, J. N. T.; Jones, K.; Rodriguez, A. I.; Fiebig, A.; Campagna, S. R.; Balunas, M. J.; O'Halloran, T. V.; Crosson, S.

10.1101/2025.05.12.653583 — microbiology — Posted on 2025-05-13

3629 How do bacterial extracellular Contractile Injection Systems bind target cells? A remarkable diversity of receptor binding domains

Nachmias, N.; Wang, Z.; Feng, X.; Jiang, F.; Levy, A.

10.1101/2025.05.13.653841 — microbiology — Posted on 2025-05-13

3630 Candida albicans epithelial invasion induces host membrane rupture at distinct subcellular niches following priming by the fungal toxin candidalysin

Conan, N.; Marthe, L.; Shekoory, A.; Latour-Lambert, P.; Franetich, J.-F.; Larsen, M.; Weiner, A.

10.1101/2025.05.13.653632 — microbiology — Posted on 2025-05-13

3631 Organic carbon oxidation state shapes fermentative methanogenic microbiomes and controls greenhouse gas fluxes

Hu, R.; Aronson, H. S.; Weaver, M. E.; Price, M. N.; Larowe, D. E.; Liang, Y.; Deutschbauer, A. M.; Coates, J. D.; Carlson, H. K.

10.1101/2025.05.12.653603 — microbiology — Posted on 2025-05-13

3632 Composition, growth, succession, and function in the Cladophora microbiome: insights from quantitative Stable Isotope Probing and NanoSIMS imaging

Fitzpatrick, R. M.; Hungate, B. A.; Power, M. E.; Schwartz, E.; Hayer, M.; Samo, T.; Weber, P.; Pett-Ridge, J.; Foley, M.; Marks, J. C.

10.1101/2025.05.12.652736 — microbiology — Posted on 2025-05-13

3633 Priming the pump: Enhanced nitrite release in response to a nitrate pulse by nitrogen-limited Prochlorococcus

Berube, P. M.; LeMaster, T.; Chisholm, S. W.

10.1101/2025.05.13.653865 — microbiology — Posted on 2025-05-13

3634 The Mycobacterium tuberculosis ESX effector promotes pyroptosis-dependent pathogenicity and dissemination

Shen, Y.; He, Y.; Chen, A.; Li, Y.; Gao, Y.; Liu, X.; Geng, L.; Ye, M.; Qiu, Y.; Zhang, L.; Sun, Y.-C.; Yang, H.; Li, J.

10.1101/2025.05.13.653593 — microbiology — Posted on 2025-05-13

3635 Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines

Addetia, A.; Schaefer, A.; Sprouse, K.; Valdez, A.; Taylor, A.; Navarro, M.-J.; Brown, J. T.; Leaf, E.; Miranda, M.; Walls, A. C.; Lee, J.; Catanzaro, N. J.; Treichel, C.; Willoughby, I.; Powers, J.; Martinez, D. R.; Vesari, B.; Ravichandran, R.; Seo, A. J.; Stewart, C.; Merz, B.; Beirne, E.; Zepeda, S.; Cook, A.; Pessaint, L.; Sharma, A.; Edwards, D.; Lee, K.; Smith, K.; Starr, T. N.; Baric, R.; King, N. P.; Veesler, D.

10.1101/2025.05.11.652904 — immunology — Posted on 2025-05-13

3636 The Contribution of the Koniocellular Visual Pathway to Aversive Learning in Human Visual Cortex

McCain, K. J.; Petro, N. M.; Keil, A.

10.1101/2025.04.24.650318 — neuroscience — Posted on 2025-05-13

3637 APOE4-induced patterned behavioral decline and neurodegeneration requires endogenous tau in a C. elegans model of Alzheimer's disease

Pierce-Shimomura, J.; Cardona, E. A.; Wu, Z.; Bolton, B. M.; Sarinay Cenik, E.

10.1101/2025.05.06.652574 — neuroscience — Posted on 2025-05-13

3638 Generative model of SARS-CoV-2 variants under functional and immune pressure unveils viral escape potential and antibody resilience

Huot, M.; Rosenbaum, P.; Planchais, C.; Mouquet, H.; Monasson, R.; Cocco, S.

10.1101/2025.05.12.653592 — bioinformatics — Posted on 2025-05-13

3639 A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets

Li, T.; La Camera, G.

10.1101/2024.08.07.606969 — bioinformatics — Posted on 2025-05-13

3640 Flexibility in Gene Coexpression at Developmental and Evolutionary Timescales

Fischer, E. K.; Song, Y.; Zhou, W.; Hoke, K. L.

10.1101/2024.12.10.627761 — evolutionary biology — Posted on 2025-05-13

3641 An AI-Guided Framework Reveals Conserved Rules Governing microRNA Strand Selection

Meadows, D.; Hargis, H. L.; Ellis, A.; Lee, H.; Mangone, M.

10.1101/2025.04.30.651563 — molecular biology — Posted on 2025-05-13

3642 Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period

Pillutla, S. V.; Skoda, M. J.; Ishii, A.; Corenblum, M. J.; Montgomery, T.; Wene, P. V.; Menakuru, N.; Kraszewski, J. N.; Billheimer, D.; Winter, G. M.; Cowen, S. L.; Madhavan, L.

10.1101/2025.05.06.652460 — neuroscience — Posted on 2025-05-13

3643 Variable performance of widely used bisulfite sequencing methods and read mapping software for DNA methylation

Kerns, E. V.; Weber, J. N.

10.1101/2025.03.14.643302 — bioinformatics — Posted on 2025-05-13

3644 Modeling Pyramidal Neurons Using Bidomain BEM and Hierarchical Matrix Approximation

Hasan, N. I.; Sabino, V.; Walenciak, A. J.; Liu, Y.; Gomez, L. J.

10.1101/2025.02.21.639592 — bioengineering — Posted on 2025-05-13

3645 Phage-displayed synthetic library and screening platform for nanobody discovery

Xia, B.; Kim, A.-R.; Liu, F.; Han, M.; Stoneburner, E.; Makdissi, S.; Di Cara, F.; Mohr, S.; Ring, A.; Perrimon, N.

10.1101/2024.12.20.629765 — biochemistry — Posted on 2025-05-13

3646 Bacteroidales T6SS minor Hcp subunits form heteromers recognising effectors

San-Miguel, S. G.; Al-Ammari, M. K. S.; Kowalska, A.; Sauer, U.; Batista, P. R.; Sandblad, L.; Uhlin, B. E.; Cisneros, D. A.

10.1101/2025.01.09.632221 — biochemistry — Posted on 2025-05-13

3647 A generative language model decodes contextual constraints on codon choice for mRNA design

Faizi, M.; Sakharova, H.; Lareau, L. F.

10.1101/2025.05.13.653614 — genomics — Posted on 2025-05-13

3648 Joint impact on thermotolerance of Saccharomyces species divergence in mitochondrial and nuclear genomes

Wang, J. T. J.; Ng, P. L. P.; Powers, M. E.; Brem, R. B.

10.1101/2025.05.07.652752 — evolutionary biology — Posted on 2025-05-13

3649 Divergent 3D genome organization in livers of cave and surface morphs of Astyanax mexicanus as a potential driver of unique metabolic adaptations in cave environment.

Biswas, T.; Li, H.; Rohner, N.

10.1101/2024.09.30.615929 — evolutionary biology — Posted on 2025-05-13

3650 Novel Fluorescent and Photoconvertible Fusions Reveal Dorsal Activator Dynamics

Turner, M. A.; Gravina, N. M.; Moretti, B.; Dima, S. S.; Martini, G.; Reeves, G. T.; Garcia, H.

10.1101/2025.05.12.653543 — developmental biology — Posted on 2025-05-13

3651 Regulation of translational fidelity by repression of C/D box SNoRNPs during UPR

Zhao, W.; Gupta, A.; Gupta, S.

10.1101/2025.05.09.653119 — cell biology — Posted on 2025-05-13

3652 P3a site-specific and cassette mutagenesis for seamless protein, RNA and plasmid engineering

Yang, X.-J.

10.1101/2025.02.03.636246 — molecular biology — Posted on 2025-05-13

3653 Chlorobaculum tepidum Outer Membrane Vesicles May Transport Biogenic Elemental Sulfur

Noundou, V. L.; Levy, A.; Modla, S.; Yu, Y.; Qu, J.; Hanson, T. E.

10.1101/2024.09.30.615447 — microbiology — Posted on 2025-05-13

3654 Gene therapy prevents disease and death from non-ketotic hyperglycinemia

Lopez-Ramirez, A.; Bali, A.; Alam, M. S.; Padmanabhan, P.; Calhoun, S.; Bickerton, C.; Flores-Mireles, A. L.; Haldar, K.

10.1101/2025.03.26.645560 — neuroscience — Posted on 2025-05-13

3655 Working memory by distributed neural oscillators in a simple nervous system

Dunn, R. L.; Costello, C.; Borchardt, J. M.; Sprague, D. Y.; Chiu, G. C.; Miller, J. M.; L'Etoile, N.; Kato, S.

10.1101/2024.08.11.607402 — neuroscience — Posted on 2025-05-13

3656 High School Science Fair: What Students Say -- Mastery, Performance, and Self-Determination Theory

Grinnell, F.; Dalley, S.; Reisch, J.

10.1101/2025.01.23.634345 — scientific communication and education — Posted on 2025-05-13

3657 Mixed DAMP/MAMP oligosaccharides promote both growth and defense against fungal pathogens of cucumber

Pring, S.; Kato, H.; Taniuchi, K.; Camagna, M.; Saito, M.; Tanaka, A.; Merritt, B. A.; Arguello-Miranda, O.; Sato, I.; Chiba, S.; Takemoto, D.

10.1101/2024.12.27.630494 — plant biology — Posted on 2025-05-13

3658 Influence of High-Fat Diet and Sex on Connective Tissue in Carpal Tunnel Syndrome

Kuroiwa, T.; Lui, H.; Nakagawa, K.; Iida, N.; Desrochers, C.; Wan, R.; Nishimura, K.; Adam, E.; Larson, D.; Amadio, P. C.; Gingery, A.

10.1101/2023.07.15.549152 — physiology — Posted on 2025-05-13

3659 DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient Survival

Iluz, A.; Lavi, N.; Charbit, H.; Gutreiman, M.; Idelson, M.; Steiner, D.; Ben-Shushan, E.; Zick, A.; Eden, A.; Mordechai, A.; Moscovici, S.; Fellig, Y.; Lossos, A.; Moss, J.; Reubinoff, B. E.; Lavon, I.

10.1101/2025.02.27.640603 — cancer biology — Posted on 2025-05-13

3660 EXPRESSION GRAPH NETWORK FRAMEWORK FOR BIOMARKER DISCOVERY

Liu, Y.; Huse, J. T.; Kannan, K.

10.1101/2025.04.28.651033 — bioinformatics — Posted on 2025-05-13

3661 MALADAPTIVE IMMUNE-FIBROTIC AXIS DRIVES IMPAIRED LONG BONE REGENERATION UNDER MECHANICAL INSTABILITY

Patrick, M.; Ahn, J.; Hankenson, K. D.; Annamalai, R. T.

10.1101/2023.10.26.564177 — bioengineering — Posted on 2025-05-13

3662 STI1 domain dynamically engages transient helices in disordered regions to drive self-association and phase separation of yeast ubiquilin Dsk2

Acharya, N.; Daniel, E. A.; Dao, T. P.; Niblo, J. K.; Mulvey, E.; Sukenik, S.; Kraut, D. A.; Roelofs, J.; Castaneda, C. A.

10.1101/2025.03.14.643327 — biochemistry — Posted on 2025-05-13

3663 DAF-16/Foxo suppresses the transgenerational sterility of prg-1 piRNA mutants via a systemic small RNA pathway

Simon, M.; Spichal, M.; Heestand, B.; Frenk, S.; Hedges, A.; Godwin, M.; Wellman, A.; Sakaguchi, A.; Ahmed, S.

10.1101/326751 — genetics — Posted on 2025-05-13

3664 DateBack, an evolving open-access repository of Phoenix archaeobotanical data supporting new perspectives on the history of date palm cultivation

Besseiche, M.; Chambraud, E.; Dabrowski, V.; Brandstatt, E.; Sabot, F.; Bouchaud, C.; Gros-Balthazard, M.

10.1101/2025.02.21.639487 — evolutionary biology — Posted on 2025-05-13

3665 Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against MCM reloading and tetraploidy

Hayashi-Takanaka, Y.; Hiratani, I.; Haraguchi, T.; Hiraoka, Y.

10.1101/2024.01.30.577900 — cell biology — Posted on 2025-05-13

3666 Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

Wang, B.; Peng, X.; Zhou, X.; Jin, X.; Siddique, A.; Yao, J.; Zhang, H.; Li, W.; Li, Y.; Yue, M.

10.1101/2024.07.09.602698 — microbiology — Posted on 2025-05-13

3667 Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

Jia, C.; Tran, A.; Aloboudi, F.; Say, E.; Thao, N.; Lee, C. R.; Batra, K.; Nguyen, A.; Bal, A.; Nono, N. N.; Delahanty, J.; Chan, M. G.; Keyes, L. R.; Patel, R. R.; Wichmann, R.; Taschbach, F.; Li, Y.; Benna, M. K.; Pereira, T. D.; Li, H.; Tye, K. M.

10.1101/2025.05.09.653162 — neuroscience — Posted on 2025-05-13

3668 A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding

Rusu, I.; Cecere, Z. T.; How, J. J.; Quach, K. T.; Yemini, E.; Sharpee, T. O.; Chalasani, S. H.

10.1101/2021.04.09.439242 — neuroscience — Posted on 2025-05-13

3669 Understanding RNA Chaperone Activity of ProQ Protein

Singh, S.; Kumari, N.; Dutta, T.; Karmakar, T.

10.1101/2025.01.17.633555 — biophysics — Posted on 2025-05-13

3670 Combining pangenomics and population genetics finds chromosomal re-arrangements, accessory-like chromosome segments, copy number variations and transposon polymorphisms in wheat and rye powdery mildew

Sotiropoulos, A. G.; Müller, M. C.; Kunz, L.; Graf, J. P.; Kiss, L.; Hückelhoven, R.; Keller, B.; Wicker, T.

10.1101/2025.05.08.652814 — genomics — Posted on 2025-05-13

3671 H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cells

Cooke, E. W.; Zeng, C.; Nur, S. M.; Jia, Y.; Huang, A.; Chen, J.; Gao, P.; CHEN, F. X.; Jin, F.; Cao, K.

10.1101/2025.05.08.652740 — genetics — Posted on 2025-05-13

3672 ACRC/GCNA is an essential protease that repairs DNA-protein crosslinks during vertebrate development

Otten, C.; Kutnjak, M.; Supina-Pavic, C.; Anticevic, I.; Medved, V.; Popovic, M.

10.1101/2023.03.07.531502 — developmental biology — Posted on 2025-05-13

3673 Mycobacterium tuberculosis suppresses protective Th17 responses during infection through multiple mechanisms

Zilinskas, A.; Balakhmet, A.; Fox, D.; Ni, H. M.; Agudelo, C.; Samani, H.; Stanley, S. A.

10.1101/2025.05.08.652811 — immunology — Posted on 2025-05-13

3674 Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

Chawla, A. S.; Watt, H. J.; Schattgen, S. A.; Skariah, N.; Saha, I.; Warrick, K.; Ogawa, M.; Lamoliatte, F.; Strid, J.; Copland, A.; Pryde, S.; Knatko, E.; Rasmussen, K. D.; Kikuchi, K.; Thomas, P. G.; Pasare, C.; Bending, D.; Swamy, M.

10.1101/2023.09.01.555859 — immunology — Posted on 2025-05-13

3675 Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Fan, X.-R.; He, Y.; Wang, Y.-S.; Li, L.; Lifespan Brain Chart Consortium (LBCC), ; China Autism Brain Imaging Consortium (CABIC), ; Duan, X.; Zuo, X.-N.

10.1101/2025.02.24.639771 — neuroscience — Posted on 2025-05-13

3676 AmygdalaGo-BOLT: an open and reliable AI tool to trace boundaries of human amygdala

Zhou, Q.; Dong, B.; Gao, P.; Jintao, W.; Xiao, J.; Wang, W.; Liang, P.; Lin, D.; Zuo, X.-N.; He, H.

10.1101/2024.08.11.607487 — neuroscience — Posted on 2025-05-13

3677 Impacts of wind-driven hydrodynamics on the early stages of coral development

Buccheri, E.; Wuppukondur, A.; Ricardo, G. F.; Mumby, P. J.; Doropoulos, C.

10.1101/2025.05.07.652727 — systems biology — Posted on 2025-05-13

3678 Direct quantitative assessment using digital droplet PCR and field-scale spatial distribution of Plasmopara viticola oospores in vineyard soil

Poeydebat, C.; Courchinoux, E.; Demeaux, I.; Rodriguez, M.; Chataigner, A.; Lelievre, M.; Goutouly, J.-P.; Rossi, J.-P.; Raynal, M.; Deliere, L.; Francois, D.

10.1101/2024.07.29.605284 — plant biology — Posted on 2025-05-13

3679 Heavy Resistance Exercise Training in Older Men: A Responder and Inter-individual Variability Analysis

Soendenbroe, C.; Andersen, J. L.; Heisterberg, M. F.; Kjaer, M.; Mackey, A. L.

10.1101/2025.05.08.652615 — physiology — Posted on 2025-05-13

3680 Modulating cerebrospinal fluid dynamics using pulsed photobiomodulation: feasibility, parameter and skin-colour dependence

Motsenyat, A.; Zhong, X.; Van Lankveld, H.; Chen, J. X.; Mathew, A.; Chen, J. J.

10.1101/2025.05.06.652458 — physiology — Posted on 2025-05-13

3681 GnnDebugger: GNN based error correction in De Bruijn Graphs

Simunovic, M.; Sikic, M.; Bankevich, A.

10.1101/2025.05.07.652713 — bioinformatics — Posted on 2025-05-13

3682 Explainable Multimodal Machine Learning Using Combined Environmental DNA and Biogeographic Features for Ecosystem Biomonitoring

Koh, J. C. O.

10.1101/2025.05.07.652781 — bioinformatics — Posted on 2025-05-13

3683 Locus-specific Convergent Evolution and Interchromosomal Rearrangements Contribute Type I Interferon Diversification in Amniotes

Zhang, L.; Ma, F.; Liu, J.; Yu, Y.; Ma, J.; Zhang, L.; Li, B.; Li, C.; Liu, P.; Zhang, L.

10.1101/2025.05.08.652797 — bioinformatics — Posted on 2025-05-13

3684 In vitro monitoring of Babesia microti infection dynamics in whole blood microenvironments

Li, C.; Bache, E. G.; Apgar, A. L.; Tufts, D. M.; Niepa, T. H. R.

10.1101/2025.05.07.652765 — bioengineering — Posted on 2025-05-13

3685 Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery

10.1101/2025.04.04.647304 — bioengineering — Posted on 2025-05-13

3686 Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

Jiang, Y.; Nikolovski, M.; Wang, T.; MacRenaris, K.; O'Halloran, T. V.; Hu, J.

10.1101/2025.05.07.652779 — biochemistry — Posted on 2025-05-13

3687 Behavior choices amongst grooming, feeding, and courting in Drosophila show contextual flexibility, not an absolute hierarchy of needs

Ladd, C. E.; Simpson, J. H.

10.1101/2025.05.09.653186 — animal behavior and cognition — Posted on 2025-05-13

3688 Transcription factor occupancy is affected by genetic variation in the white adipose tissue of C57BL6/j and 129S1/SvImJ mice

Mononen, J.; Taipale, M.; Malinen, M.; Levonen, A.-L.; Ruotsalainen, A.-K.; Norton, L.; Heikkinen, S.

10.1101/2025.05.08.652810 — genetics — Posted on 2025-05-13

3689 Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms

Lardennois, A.; Dingare, C.; Duda, V.; Klemmt, P. A.; Heinzen, C.; Kleinhans, D.; Falk, T.; Schelmbauer, C.; Mozolewska, O.; Papadopoulou, S.; Lai, J. J. K.; Stainier, D. Y. R.; Lecaudey, V.

10.1101/2025.05.08.652796 — developmental biology — Posted on 2025-05-13

3690 A Novel Framework for Quantitative Analysis of Neuronal Primary Cilia in Brain Tissue

H.Rafati, A.; Rasmusson, S.; Jabbari Shiadeh, S. M.; J Rosario, F.; Jansson, T.; Mallard, C.; Ardalan, M.

10.1101/2025.05.09.653053 — neuroscience — Posted on 2025-05-13

3691 Single-Cell Trajectory Inference for Detecting Transient Events in Biological Processes

Hutton, A.; Meyer, J. G.

10.1101/2025.05.07.652753 — bioinformatics — Posted on 2025-05-13

3692 scGenAI: A generative AI platform with biological context embedding of multimodal features enhances single cell state classification

Wang, R.; Ung, M.; Ge, H. G.

10.1101/2025.05.07.652733 — bioinformatics — Posted on 2025-05-13

3693 Pseudoassembly of k-mers

Sullivan, D. K.; Boffelli, M.; Pachter, L.

10.1101/2025.05.11.653354 — bioinformatics — Posted on 2025-05-13

3694 rDNAcaller: a fast and robust pipeline to call ribosomal DNA variants

Ramirez, J. M.; Oliveros, W.; Garcia-Perez, R.; Jimenez-Lupianez, A.; Shah, A.; Perez-Cano, P.; Reese, F.; Vazquez, M.; Mele, M.

10.1101/2025.05.13.653643 — bioinformatics — Posted on 2025-05-13

3695 Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy

Flannery, K. P.; Mowla, S.; Battula, N.; Clark, L. R.; Liu, D.; Oliveira, C. D.; Venkatesan, C.; Simhon, L. M.; Karas, B. F.; Terez, K. R.; Burbano Lombana, D.; Manzini, M. C.

10.1101/2025.05.13.653769 — genetics — Posted on 2025-05-13

3696 Transcriptional Subtypes on Immune Microenvironment and Predicting Postoperative Recurrence and Metastasis in Pheochromocytoma and Paraganglioma

Liu, Y.; Yan, X.; Zhang, Y.; Gao, Z.; Nan, F.; Shi, S.; Chen, J.; Li, L.

10.1101/2025.05.12.653406 — cancer biology — Posted on 2025-05-13

3697 Transcriptional Repression by RelA and Yin Yang1 is essential for survival of Colorectal Cancer Cells

Mutra, R.; Vallabhapurapu, S.

10.1101/2025.05.12.653423 — cancer biology — Posted on 2025-05-13

3698 A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription

Minello, A.; Gomez-Escudero, J.; Sridhara, S. C.; Martin, C.; Girard, E.; Canas, J. C.; Memari, Y.; Bustos, M. R.; Galarreta, A.; Boucherit, V.; Imyanitov, E.; Bodvarsdottir, S. K.; Baulande, S.; Vincent-Salomon, A.; Servant, N.; Altmeyer, M.; Sigurdsson, S.; Stoppa-Lyonnet, D.; Nik-Zainal, S.; Carreira, A.

10.1101/2025.05.12.652853 — cancer biology — Posted on 2025-05-13

3699 p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

Kumar, R.; Couly, S.; Muys, B. R.; Li, X. L.; Grammatikakis, I.; Singh, R.; Guest, M.; Wen, X.; Tang, W.; Ambs, S.; Jenkins, L. M.; Pehrsson, E. C.; Chari, R.; Su, T.-P.; Lal, A.

10.1101/2025.05.12.653341 — cancer biology — Posted on 2025-05-13

3700 The adenovirus E4orf1 protein initiates a feedback loop involving insulin and growth factor receptors, AKT, and NF-κB, leading to abnormal DNA content in infected cells

Moore, M.; Kong, J.; Akmel, A.; Thomas, M. A.

10.1101/2025.05.12.653445 — cancer biology — Posted on 2025-05-13

3701 Development of a liquid biopsy for bladder cancer using a mutant protein panel in urinary extracellular vesicles

Hakozaki, Y.; Sugimoto, K.; Yamada, Y.; Danno, T.; Hashimoto, K.; Shinchi, H.; Kume, H.; Ueda, K.

10.1101/2025.05.12.653366 — cancer biology — Posted on 2025-05-13

3702 CD4+ T-cells sensitize quasi-mesenchymal breast tumors lacking CD73 to anti-CTLA4 immune checkpoint blockade therapy

Chandraganti, S. R.; Sams, C.; Sahoo, S.; Feng, B.; O'Connell, I.; Li, L.; Nepal, S.; Pulukuri, S.; Bakhle, K.; Thiru, P.; Simian, C.; Bell, G. W.; Jolly, M. K.; Dongre, A.

10.1101/2025.05.12.653467 — cancer biology — Posted on 2025-05-13

3703 Cancer cell deformability impacts the rate of confined migration but not decision making

van der Net, A.; Boot, R. C.; van Dijk, I.; Conboy, J. P.; Boukany, P. E.; Koenderink, G. H.

10.1101/2025.05.12.653524 — cancer biology — Posted on 2025-05-13

3704 Local, but not circulating, complement C3 governs immune checkpoint blockade efficacy

Miyai, Y.; Shiraki, Y.; Sugiyama, D.; Sato, Y.; Kato, K.; Asai, N.; Cao, F.; Nagao, N.; Tanabe, K.; Nakatochi, M.; Hase, T.; Yoshikawa, T. F. C.; Kobayashi, T.; Iwama, S.; Esaki, N.; Mii, S.; Arima, H.; Kimura, H.; Takahashi, M.; Ando, Y.; Enomoto, A.

10.1101/2025.05.12.653608 — cancer biology — Posted on 2025-05-13

3705 Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product

Jagannathan, N. S.; Sin, W.-X.; Teo, D. B. L.; Kairi, F.; Luah, Y. H.; Lim, F. L. W. I.; Seng, M. S.-F.; Soh, S. Y.; Lee, Y. H.; Tucker-Kellogg, L.; Birnbaum, M. E.; Ram, R. J.

10.1101/2025.05.11.653250 — cancer biology — Posted on 2025-05-13

3706 rplec: An R package of placental epigenetic clock to estimate aging by DNA-methylation-based gestational age

Sufriyana, H.; Su, E. C.-Y.

10.1101/2025.02.04.636367 — bioinformatics — Posted on 2025-05-13

3707 Evolution of a novel left-right asymmetry in organ size byco-option of a tissue rotation process

Lefevre, B. M.; Delvigne, M.; Camprodon, A.; Vidal, J.; Courtier-Orgogozo, V.; Lang, M.

10.1101/2022.01.16.476383 — evolutionary biology — Posted on 2025-05-13

3708 WITHDRAWN: A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial germ cell development

Li, L.; Ding, X.; Sheft, A.; Schimenti, J. C.

10.1101/2024.02.26.582097 — developmental biology — Posted on 2025-05-13

3709 Mechanistic modeling identifies emergent properties of tandem SH2 domain interactions

Portelance, R.; Wu, A.; Kandoor, A.; Naegle, K. M.

10.1101/2025.05.13.653723 — molecular biology — Posted on 2025-05-13

3710 Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

Mukherjee, A.; Huang, Y.; Oh, S.; Sanchez, C.; Chang, Y.-F.; Liu, X.; Bradshaw, G. A.; Benites, N. C.; Paulsson, J.; Kirschner, M. W.; Sung, Y.; Elgeti, J.; Basan, M.

10.1101/2023.08.31.555748 — microbiology — Posted on 2025-05-13

3711 Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

Jian, F.; Wec, A. Z.; Feng, L.; Yu, Y.; Wang, L.; Wang, P.; Yu, L.; Wang, J.; Hou, J.; Berrueta, D. M.; Lee, D.; Speidel, T.; Ma, L.; Kim, T.; Yisimayi, A.; Song, W.; Wang, J.; Liu, L.; Yang, S.; Niu, X.; Xiao, T.; An, R.; Wang, Y.; Shao, F.; Wang, Y.; Pecetta, S.; Wang, X.; Walker, L. M.; Cao, Y.

10.1101/2024.04.16.589454 — immunology — Posted on 2025-05-13

3712 Explainable Machine Learning Identifies Dosage Compensation Factors in Aneuploid Human Cancer Cells

Heller, E. M.; Barthel, K.; Raschle, M.; Schukken, K.; Sheltzer, J.; Storchova, Z.

10.1101/2025.05.12.653427 — cancer biology — Posted on 2025-05-13

3713 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Li, Y.

10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-05-13

3714 Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Saraswat, M.; Rueda-Gensini, L.; Heinzelmann, E.; Gracia, T.; Memi, F.; de Jong, G.; Straub, J.; Schloo, C.; Hoffmann, D. C.; Jung, E.; Kindinger, T.; Weigel, B.; Lim, B.; Weil, S.; Gould, O.; Mair, R.; Mikulik, K.; Rohbeck, M.; Wick, W.; Winkler, F.; Bayraktar, O. A.; Stegle, O.; Mall, M.

10.1101/2025.05.13.653733 — cancer biology — Posted on 2025-05-13

3715 Oxidative Base Damage to Telomeres Sensitizes Cancer Cells to ATR Inhibition

Garbouchian, A.; Cestari Moreno, N.; Dey, A.; Opresko, P.; Barnes, R. P.

10.1101/2025.05.10.653274 — cancer biology — Posted on 2025-05-13

3716 Mechanoimmunological Control of Metastatic Site Selection

Elbanna, Y. A.; Tello-Lafoz, M.; Holland, A.; Zhang, Y.; Kwak, J.-G.; Wang, Z.; Yakimov, A.; Dada, M.; Vayner, S.; Duquette, S. M.; Kim, Y. H.; Bale, T.; Winer, B. Y.; Yu, K. K. H.; Massague, J.; Lee, J.; Barzilai, O.; Manalis, S. R.; Huse, M.

10.1101/2025.05.10.653256 — cancer biology — Posted on 2025-05-13

3717 Resistance to the KRASG12D Inhibitor MRTX1133 is Associated with Increased Sensitivity to BET Inhibition

Principe, D. R.; Becker, J. H.; Metropulos, A. E.; Marinelarena, A. M.; Pham, T. D.; Aissa, A. F.; Munshi, H. G.

10.1101/2025.05.10.653074 — cancer biology — Posted on 2025-05-13

3718 Schistosomiasis parasite enhance transmission rates via interfacial swimming

Hannebelle, M.; Ho, I.; N'diaye, A.; Prakash, M.

10.1101/2025.05.13.653683 — biophysics — Posted on 2025-05-13

3719 Structural Basis for Retron Co-option of Anti-phage ATPase-nuclease

Wang, B.; Hoffman, R.; Hou, Y.-M.; Li, H.

10.1101/2025.05.10.653283 — biophysics — Posted on 2025-05-13

3720 An inductive, supervised approach for predicting gene--disease associations using phenotype ontologies

Bakheet, S.; Zhapa-Camacho, F.; Hoehndorf, R.

10.1101/2025.05.07.652682 — bioinformatics — Posted on 2025-05-13

3721 Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry

Welp, L. M.; Wulf, A.; Chernev, A.; Horokhovskyi, Y.; Moshkovskii, S.; Dybkov, O.; Neumann, P.; Pasen, M.; Siraj, A.; Raabe, M.; Goethert, H.; Walshe, J. L.; Infante, D. A.; de A.P. Schwarzer, A. C.; Dickmanns, A.; Johannsson, S.; Schmitzova, J.; Wohlgemuth, I.; Netz, E.; He, Y.; Fritzemeier, K.; Delanghe, B.; Viner, R.; Vos, S.; Oberbeckmann, E.; Bohnsack, K. E.; Bohnsack, M. T.; Cramer, P.; Ficner, R.; Liepe, J.; Kohlbacher, O.; Sachsenberg, T.; Urlaub, H.

10.1101/2024.08.29.610268 — biochemistry — Posted on 2025-05-13

3722 Conformational biosensors delineate endosomal G protein regulation by GPCRs

Wysolmerski, B.; Blythe, E. E.; von Zastrow, M.

10.1101/2025.05.12.653522 — cell biology — Posted on 2025-05-13

3723 When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion

Dengler, L.; Padovani, F.; Lemke, B.; Brugger, R.; Westermann, B.; Macek, B.; Schmoller, K. M.; Ewald, J. C.

10.1101/2025.05.13.653688 — cell biology — Posted on 2025-05-13

3724 KIF5B and Dynein regulate adhesion-dependent Golgi organization and microtubule acetylation

Chakraborty, A.; Pitke, S.; BR, R.; Buwa, N.; Dasgupta, A.; Behera, R.; Jayakrishnan, M.; Balasubramanian, N.

10.1101/2025.05.11.653231 — cell biology — Posted on 2025-05-13

3725 Antibiotic treatment modulates Escherichia coli-derived bacterial extracellular vesicle (BEV) production and their capacity to upregulate ICAM-1 in human endothelial cells

Widom, L. P.; Torabian, P.; Wojehowski, A. C.; Ghaemmaghami, S.; Michel, L. V.; Gaborski, T. R.

10.1101/2025.05.12.653517 — cell biology — Posted on 2025-05-13

3726 Mechanical forces drive mitochondrial matrix extrusion and apoptotic pore growth

Jenner, A.; Dellmann, T.; Kim, H.; Gomez, D.; Zollo, C.; Koefinger, J.; Seidel, K.; Gaedke, F.; Schauss, A.; Hummer, G.; Garcia-Saez, A. J.

10.1101/2025.05.12.653510 — cell biology — Posted on 2025-05-13

3727 Dynein synergises with EB1 to facilitate cortex-microtubule encounter and proper spindle positioning in metaphase

Efstathiou, C.; Ojkic, N.; Draviam, V. M.

10.1101/2025.05.12.653564 — cell biology — Posted on 2025-05-13

3728 Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration

Murray-Cors, S.; Owens, M.; Liew, Y.-T.; Day, M.; Cairns, W.; Prokop, A.

10.1101/2025.05.11.653329 — cell biology — Posted on 2025-05-13

3729 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway

10.1101/2025.05.13.652513 — cell biology — Posted on 2025-05-13

3730 A key role for Canoes intrinsically disordered region in linking cell junctions to the cytoskeleton

Jensen, C.; Gurley, N.; Mathias, A.; Wolfsbrrg, L.; Xiao, Y.; Zhou, Z.; Slep, K. C.; Peifer, M.

10.1101/2025.05.10.653259 — cell biology — Posted on 2025-05-13

3731 CellSeg3D: self-supervised 3D cell segmentation for fluorescence microscopy

Achard, C.; Kousi, T.; Frey, M.; Vidal, M.; Paychere, Y.; Hofmann, C.; Iqbal, A.; Hausmann, S. B.; Pages, S.; Mathis, M. W.

10.1101/2024.05.17.594691 — cell biology — Posted on 2025-05-13

3732 The role of effort in adaptation to split-belt locomotion

Marbaker, R. M.; Idoine, Y.; Ahmed, A. A.

10.1101/2025.05.07.652669 — neuroscience — Posted on 2025-05-13

3733 The contribution of the locus coeruleus-norepinephrine system to the coupling between pupil-linked arousal and cortical state

Weiss, E.; Liu, Y. A.; Wang, Q.

10.1101/2025.05.07.652771 — neuroscience — Posted on 2025-05-13

3734 Thermal cycling stimulation via nasal inhalation attenuates Aβ25-35-induced cognitive deficits in C57BL/6 mice

Lin, G.-B.; LIU, H.-H.; Kuo, Y.-Y.; CHEN, Y.-M.; Hsu, F.-T.; Wang, Y.-W.; Kung, Y.; Ching, C.; Chao, C.-Y.

10.1101/2025.05.08.652792 — neuroscience — Posted on 2025-05-13

3735 A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson's disease

Zhang, J.-X.; Smyth, C.; Anjum, M. F.; Leng, Y.; Krystal, A. D.; Starr, P. A.; Little, S.

10.1101/2025.05.07.652676 — neuroscience — Posted on 2025-05-13

3736 No facilitatory effects of transcranial random noise stimulation on motion processing: A registered report

Edwards, G.; Ruhde, R.; Carroll, M. B.; Baker, C. I.

10.1101/2025.03.18.643903 — neuroscience — Posted on 2025-05-13

3737 Neuropeptide signalling and perineurial barrier generate a persistent stress-induced internal state in Drosophila

Alia, A. G.; Hu, X.; Gu, Y.; Tian, G.; Semmelhack, J.; Saito, K.; Tanimoto, H.; Tsuyuzaki, K.; Naganos, S.; Miyashita, T.; Saitoe, M.; Hirano, Y.

10.1101/2025.05.08.652787 — neuroscience — Posted on 2025-05-13

3738 Sensitive and easily democratized environmental DNA methods for low-risk surveillance of at-risk bumble bees

Richardson, R.; Avalos, G.; Garland, C.; Trott, R.; Hager, O.; Hepner, M.; Goodell, K.

10.1101/2025.05.13.649340 — ecology — Posted on 2025-05-13

3739 Changes in slow oscillations and sleep spindles by auditory stimulation positively correlate with memory consolidation in children with epilepsy and controls

Kwon, H.; Chinappen, D. M.; Wodeyar, A.; Kinard, E. A.; Goodman, S. K.; Shi, W.; Baxter, B. S.; Manoach, D. S.; Kramer, M. A.; Chu, C. J.

10.1101/2025.05.12.653459 — neuroscience — Posted on 2025-05-13

3740 Temporal coding carries more stable cortical visual representations than firing rate over time

Zhu, H.; He, F.; Zolotavin, P.; Patel, S.; Tolias, A.; Luan, L.; Xie, C.

10.1101/2025.05.13.652528 — neuroscience — Posted on 2025-05-13

3741 Individual differences in fear memory expression engage distinct functional brain networks

Fontana, B. D.; Hudock, J.; Rajput, N.; Kanani, D.; Luong, D.; Kenney, J. W.

10.1101/2025.05.12.653531 — neuroscience — Posted on 2025-05-13

3742 Longitudinal monitoring of developmental plasticity in the mouse auditory cortex

Kirchgessner, M.; Vaze, M.; Froemke, R. C.

10.1101/2025.05.12.653595 — neuroscience — Posted on 2025-05-13

3743 BrainVAE: Exploring the role of white matter BOLD in preclinical Alzheimer disease classification

Li, Y.; Xu, L.; Zuo, L.; Chang, Y.; Ding, Z.; Anderson, A. W.; Schilling, K.; Gore, J. C.; Gao, Y.

10.1101/2025.05.07.652697 — neuroscience — Posted on 2025-05-13

3744 AlphaFold3 and RoseTTAFold All-Atom structures enable radiosensitizers discovery by targeting multiple DNA damage repair proteins

Tong, J.; Wang, X.; Lu, M.; Wang, T.; Chen, J.; Chen, J.; Li, Y.; Xie, C.; Fu, Y.; Yu, C.

10.1101/2025.03.26.645385 — cancer biology — Posted on 2025-05-13

3745 Quantifying biological heterogeneity in nano-engineered particle-cell interaction experiments

Murphy, R. J.; Faria, M.; Osborne, J. M.; Johnston, S. T.

10.1101/2025.02.01.636020 — biophysics — Posted on 2025-05-13

3746 Long-lasting coexistence of multiple asexual lineages alongside their sexual counterparts in a fungal plant pathogen

Abdalrahem, A.; Andrieux, A.; Becheler, R.; Duplessis, S.; Frey, P.; Marcais, B.; Schiffer-Forsyth, K.; Stoeckel, S.; Halkett, F.

10.1101/2025.03.28.645883 — evolutionary biology — Posted on 2025-05-13

3747 Evolution under Domestication: Genetic differentiation in black soldier fly (Hermetia illucens) populations subjected to recent selective breeding

Silvaraju, S.; Loh, R. K.; Kittelmann, S.; Puniamoorthy, N.

10.1101/2025.04.14.648847 — evolutionary biology — Posted on 2025-05-13

3748 Untangling the effects of within-host and between-host natural selection in viruses with applications to evolution of HIV-1 co-receptor usage

Drake, K. O.; Franceschi, V. B.; Nascimento, F. F.; Volz, E. M.

10.1101/2025.05.08.652803 — evolutionary biology — Posted on 2025-05-13

3749 Varroa mites escape the evolutionary trap of haplodiploidy

Eliash, N.; Tetsuya, E.; Hua, X.; Johnston, S. J.; TECHER, M. A.; Holmes, V. R.; Rangel, J.; Zheng, H.; Economo, E. P.; Mikheyev, A. S.

10.1101/2024.05.10.593493 — evolutionary biology — Posted on 2025-05-13

3750 Viral lifecycle dynamics and spatial structure explain why pathogenicity isprophage-encoded

Nazir, S. A.; van Dijk, B.

10.1101/2025.02.28.640786 — evolutionary biology — Posted on 2025-05-13

3751 Identification and functional characterization of toluene degradation genes in Acinetobacter sp. Tol 5

Yoshimoto, S.; Hattori, M.; Inoue, S.; Mori, S.; Ohara, Y.; Hori, K.

10.1101/2025.05.12.653411 — microbiology — Posted on 2025-05-13

3752 Revisiting sour rot of grapevine through disease-associated microbiomes: a tripartite co-infection?

Wilhelm, M.; Hevin, S.; Kehrli, P.; Buyck, B.; Gindro, K.; Wolfender, J.-L.; Hofstetter, V.

10.1101/2024.09.19.613941 — microbiology — Posted on 2025-05-13

3753 Phenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt

Eladawy, M.; Heslop, N.; Negus, D.; Thomas, J.; Hoyles, L.

10.1101/2025.04.17.649370 — microbiology — Posted on 2025-05-13

3754 Aperiodic neural timescales in prefrontal cortex dilate with increased task abstraction

Cellier, D.; Riddle, J.; Hammonds, R.; Frohlich, F.; Voytek, B.

10.1101/2025.04.21.649913 — neuroscience — Posted on 2025-05-13

3755 EEG-based Assessment of Long-Term Vigilance and Lapses of Attention using a User-Centered Frequency-Tagging Approach

Ladouce, S.; Torre-Tresols, J. J.; Le Goff, K.; Dehais, F.

10.1101/2024.12.12.628208 — neuroscience — Posted on 2025-05-13

3756 High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain

Wu, H.; Maekawa, Y.; Eno, S.; Kondo, S.; Yamagata, N.; Tanimoto, H.

10.1101/2024.12.02.626511 — neuroscience — Posted on 2025-05-13

3757 Sex differences in the rates and association of cerebral blood flow and glucose metabolism in normative ageing.

Deery, H.; Moran, C.; Liang, E. X.; Gurvich, C.; Egan, G. F.; Jamadar, S. D.

10.1101/2024.11.27.625794 — neuroscience — Posted on 2025-05-13

3758 Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

Sengupta, A.; Vinayagamurthy, S.; Soni, D.; Deb, R.; Mukherjee, A. K.; Dutta, S.; Jaiswal, J.; Yadav, M.; Sharma, S.; Bagri, S.; Roy, S. S.; Poonia, P.; Singh, A.; Khanna, D.; Bhatt, A. K.; Sharma, A.; Saurav, S.; Motiani, R. K.; Chowdhury, S.

10.1101/2023.10.09.561466 — cancer biology — Posted on 2025-05-13

3759 Differential interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

Datta, A.; Dewan, P.; Anto, A.; Chhabra, T.; Tejaswi, T.; Muthukrishnan, S.; Rao, A.; Sarkar, S.; Vishwakarma, M.

10.1101/2025.03.14.643229 — biophysics — Posted on 2025-05-13

3760 Localized Reactivity on Protein as Riemannian Manifolds: A Geometric and Quantum-Inspired Basis for Deterministic, Metal-Aware Reactive-Site Prediction

Park, H.

10.1101/2025.04.29.651260 — bioinformatics — Posted on 2025-05-13

3761 NeuroVelo: interpretable learning of cellular dynamics from single-cell transcriptomic data

Kouadri Boudjelthia, I.; Milite, S.; El Kazwini, N.; Huang, Y.; Sottoriva, A.; Sanguinetti, G.

10.1101/2023.11.17.567500 — bioinformatics — Posted on 2025-05-13

3762 SimdMinimizers: Computing random minimizers, fast

Groot Koerkamp, R.; Martayan, I.

10.1101/2025.01.27.634998 — bioinformatics — Posted on 2025-05-13

3763 Genomic diversity and antimicrobial resistance ofStaphylococcus aureus in Saudi Arabia: a nationwide studyusing whole-genome sequencing

Alarawi, M. S.; Altammami, M.; H. Abutarboush, M.; Kulmanov, M.; Mawsil Alkuraythi, D.; Kafkas, S.; Radley, R.; Abdelhakim, M.; Aldakhil, H. M.; A. Bawazeer, R.; A. Alolayan, M.; M. Alnafjan, B.; A. Huraysi, A.; Almaabadi, A.; A Suliman, B.; G Aljohani, A.; A. Hemeg, H.; Abujamel, T. S.; Hashem, A. M.; Al-Zahrani, I. A.; S Abdoh, M.; I Hobani, H.; F Felemban, R.; A Alhazmi, W.; Hong, P.; Alghoribi, M. F.; Al Johani, S. M.; BALKHY, H. H.; Alswaji, A. A.; ALZAYER, M.; Alalwan, B.; Kaaki, M.; Hala, S.; Ahmad Fallatah, O.; Ahmad Bahitham, W.; Yahya Zakri, S.; A Alshehri, M.; Kameli, N.; Algaissi,

10.1101/2025.03.03.641358 — genomics — Posted on 2025-05-13

3764 Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

Chen, S.; Liang, J.; Yin, J.; Zhang, W.; Jiang, P.; Wang, W.; Chen, X.; Zhou, Y.; Xia, P.; Yang, F.; Gu, Y.; Zhang, R.; Han, p.

10.1101/2024.05.09.593293 — developmental biology — Posted on 2025-05-13

3765 Modeling tissue-resident macrophage development from mouse pluripotent stem cells

Baako, A. K.; Vijayakumar, R.; Medina-Cano, D.; Wang, Z.; Romero-Pichardo, J.; Fadojutimi, K.; Do, S. C.; Lin, Y.; Islam, M. T.; Dixit, S.; Trzeciak, A.; Perry, J. S. A.; Vierbuchen, T.

10.1101/2025.05.01.651743 — developmental biology — Posted on 2025-05-13

3766 Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure

Sezgin, E.

10.1101/2025.05.07.652622 — biophysics — Posted on 2025-05-13

3767 An Orc6 tether mediates ORC binding site switching during replication origin licensing

Driscoll, D.; Friedman, L. J.; Gelles, J.; Bell, S. P.

10.1101/2025.05.09.652650 — biochemistry — Posted on 2025-05-13

3768 Nickel binding to a split ATCUN motif in c-Src SH3 domain facilitates crystallization

Calicdan, X.; Fisher, O. S.; Ha, B. H.; Boggon, T. J.; Stiegler, A. L.

10.1101/2025.05.08.652639 — biochemistry — Posted on 2025-05-13

3769 Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans

Zhao, Q.; Bolton, B.; Rothe, R.; Tachibana, R.; Cenik, C.; Sarinay Cenik, E.

10.1101/2025.05.07.652686 — genetics — Posted on 2025-05-13

3770 Rhs-toxin Abundance, Diversity, and Function in Four Genera of Plant Pathogenic Bacteria: Xanthomonas, Ralstonia, Pectobacterium, and Dickeya.

Gomez Cabrera, A.; Ameen, Y. O.; DAmico-Willman, K.; Joglekar, P.; Huguet-Tapia, J.; Carbone, I.; Huerta Vazquez, A. I.

10.1101/2025.05.08.652813 — ecology — Posted on 2025-05-13

3771 Supervised and unsupervised machine learning methods for modelling current and future habitat of Peruvian anchovy

Cruz, M. H.; Xue, T.; Hauschildt, J.; Gutierrez, M.; Kemena, T.

10.1101/2025.05.08.652876 — ecology — Posted on 2025-05-13

3772 Generalized dynamics of cooperating bacteria

Massing, J. C.; Gross, T.; Yeakel, J. D.; Fahimipour, A. K.

10.1101/2025.05.08.652847 — ecology — Posted on 2025-05-13

3773 Customized and rapid observational delimiting surveys for plant pests based on transect data and scouting

Caton, B.; Pallipparambil, G.; Fang, H.

10.1101/2025.05.08.652837 — ecology — Posted on 2025-05-13

3774 Alterations to cellular metabolism are linked to multiple natural parasite infections across populations of a freshwater fish

Melancon, V.; Binning, S. A.; Cote, A.; Breton, S.

10.1101/2025.05.08.652957 — ecology — Posted on 2025-05-13

3775 A 20-years comparative study of domoic acid depuration in king scallops, Pecten maximus, across French provinces.

Le Moan, E.; Derrien, A.; Fabioux, C.; Jean, F.; Lassudrie, M.; Terre-Terrillon, A.; Hegaret, H.; Flye-Sainte-Marie, J.

10.1101/2025.05.08.652798 — ecology — Posted on 2025-05-13

3776 Trans-kingdom coupling of redox signaling to environmental cell stress responses through multiphase partitioning.

Ngwa, E.; Chen, X.; Schmeider, S.; Maurais, A.; Svistunov, V.; Peng, Q.; Moore, I.; Lencer, W. I.; Weerapana, E.; Raghunathan, K.; Thiagarajah, J. R.

10.1101/2025.05.09.653213 — cell biology — Posted on 2025-05-13

3777 High Content System for Quantifying Mitochondrial Morphology in Patient-Derived Human Cells

Deschamps, K.; Laville-Dupuy, S. R.; Peng, C. Y.; Truant, R.

10.1101/2025.05.08.652922 — cell biology — Posted on 2025-05-13

3778 Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice

Xu, P.; Mancuso, R. I.; Leonzino, M.; Zeiss, C. J.; Krause, D. S.; De Camilli, P.

10.1101/2025.05.09.653147 — cell biology — Posted on 2025-05-13

3779 Regulation of translational fidelity by repression of C/D box SNoRNPs during UPR

Gupta, S.; Gupta, A.; Zhao, W.

10.1101/2025.05.09.653119 — cell biology — Posted on 2025-05-13

3780 Molecular determinants of species-specific cell-cell recognition activating the class II gamete fusogen HAP2

Pinello, J. F.; Ferrino, A.; Hussain, H.; Legrand, P.; Manikumar, S.; Demissie, R.; Rey, F. A.; Snell, W. J.; Baquero, E.

10.1101/2025.05.09.653094 — cell biology — Posted on 2025-05-13

3781 The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins

Thapa, R.; Kayejo, V. G.; Naglik, J. R.; Hube, B.; Keyel, P. A.

10.1101/2025.05.09.653080 — cell biology — Posted on 2025-05-13

3782 Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism

Medeiros, T. C. D.; Reato, S.; Li, X.; Garcia, B. M.; Rais, I.; Allmeroth, K.; Hartman, M.; Denzel, M.; Purrio, M.; Mesaros, A.; Leung, K.-y.; Greene, N.; Giavalisco, P.; Pernas, L.

10.1101/2025.05.07.652698 — cell biology — Posted on 2025-05-13

3783 AMFR provides an ERAD bypass mechanism to maintain proteostasis under canonical E3 ligase deficiency

Nakayamada, U.; Fujii, A.; Katoh, S.; Kamada, Y.; Okiyoneda, T.

10.1101/2025.05.07.652780 — cell biology — Posted on 2025-05-13

3784 In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone Metabolome

Chlebek, C.; McAndrews, C.; Aaronson, B.; Welhaven, H.; Yu, K.; Costa, S. N.; Shaver, J.; Silvia, S.; DeMambro, V.; June, R. K.; McGee-Lawrence, M. E.; Rosen, C. J.

10.1101/2025.05.09.653133 — cell biology — Posted on 2025-05-13

3785 The endoplasmic reticulum promotes microtubule organization and region-specific disassembly to execute Compartmentalized Cell Elimination

Juanez, K.; Selvarathinam, H.; Jones, M.; Ghose, P.

10.1101/2025.05.08.652974 — cell biology — Posted on 2025-05-13

3786 SF3B1K700E Drives Oncogenic Alternative Splicing of Cell Cycle Checkpoint Genes in Cancer

Baker, M.; Sharma, A.; Engal, E.; Petasny, M.; Jaffe-Herman, S.; Geminder, O.; Su, M.; Bentata, M.; Kay, G.; Salton, M.

10.1101/2025.05.08.652831 — molecular biology — Posted on 2025-05-13

3787 N-Myc downstream regulated gene 1b is a regulator of cell adhesion during early muscle development

Chowdhary, P. K.; Brewster, R. M.

10.1101/2025.05.08.652902 — molecular biology — Posted on 2025-05-13

3788 Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?

Carolus, H.; Diaz, J.; Biriukov, V.; Jacobs, S.; Sofras, D.; Pageau, A.; Romero, C. L.; Vinken, L.; Escribano, P.; Guinea, J.; Lagrou, K.; Landry, C.; Gabaldon, T.; Van Dijck, P.

10.1101/2025.05.08.652905 — molecular biology — Posted on 2025-05-13

3789 Proteomic and lipidomic profiling of immune cell-derived subpopulations of extracellular vesicles

Lischnig, A.; Karimi, N.; Larsson, P.; Ekstrom, K.; Crescitelli, R.; Olin, A.-C.; Lasser, C.

10.1101/2025.05.08.652936 — molecular biology — Posted on 2025-05-13

3790 Alcohol impacts an fMRI marker of neural inhibition in humans and rodents.

Nishio, M.; Wang, X.; Cornblath, E. J.; Lee, S.-H.; Shih, Y.-Y. I.; Palomero-Gallagher, N.; Arcaro, M.; Lydon-Staley, D. M.; Mackey, A. P.

10.1101/2025.05.07.652668 — neuroscience — Posted on 2025-05-13

3791 Mapping Functional Homologies Between Human and Marmoset Brain Networks Using Movie-Driven Ultra-High Field fMRI

Zanini, A.; Dureux, A.; Menon, R.; Everling, S.

10.1101/2025.05.07.652702 — neuroscience — Posted on 2025-05-13

3792 A Comparative Study of Novel Microscopic Entities in Rock Samples: Implications for Panspermia and the Origin of Life.

Castano, J. M. G.; Alzate, D. M. M.; Zapata, F. A.; Hoyos, M. H.; Martinez, R. R.

10.1101/2025.05.07.652759 — systems biology — Posted on 2025-05-13

3793 α-Synuclein purification significantly impacts seed amplification assay performance and consistency

Al-Azzawi, Z. A. M.; Silver, N. R. G.; Niu, S.; Luo, W.; Shlaifer, I.; Ingelsson, M.; Hyman, B. T.; Trempe, J.-F.; Durcan, T.; Watts, J. C.; Fon, E. A.

10.1101/2025.05.08.652548 — biochemistry — Posted on 2025-05-13

3794 Novel Fluorescent and Photoconvertible Fusions Reveal Dorsal Activator Dynamics

Turner, M. A.; Gravina, N. M.; Moretti, B.; Dima, S. S.; Martini, G.; Reeves, G. T.; Garcia, H.

10.1101/2025.05.12.653543 — developmental biology — Posted on 2025-05-13

3795 Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production

Beckendam, R. H.; Camacho, V.; Stone, A. P.; Barrachina, M. N.; Branfield, S.; Carminita, E.; Becker, I. C.; Lee, D. H.; Walsey, E.; Kaplan, J.; Payne, C.; Tilburg, J.; Pal, S.; Batista, L. F. Z.; Italiano, J. E.; Machlus, K. R.

10.1101/2025.05.08.652525 — cell biology — Posted on 2025-05-13

3796 Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

Kabir, T.; Connamacher, C. A.; Nadeem, Z.; Paul, M. R.; Smutny, M. R.; Lawler, Z. K.; Djomo, A. M.; Carroll, T.; Gates, L. A.

10.1101/2025.05.07.652677 — cell biology — Posted on 2025-05-13

3797 Tet1 safeguards lineage allocation in intestinal stem cells

Gleizes, A.; Janto, N.; Bombin, S.; Rao, V.; Ari, G.; Sun, S.; Fonseca, M. V.; Gracz, A. D.

10.1101/2025.05.08.652522 — cell biology — Posted on 2025-05-13

3798 Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation

Abdelazim, H.; Alsalman, M.; Wheeler, M.; Pfleger, J.; Chappell, J. C.

10.1101/2025.05.07.652722 — cell biology — Posted on 2025-05-13

3799 The proteostatic landscape of healthy human oocytes

Boke, E.; Zaffagnini, G.; Duran, J. M.; Sole, M.; Polyzos, N. P.

10.1101/2025.05.08.652885 — cell biology — Posted on 2025-05-13

3800 Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

Rodriques, A.; Liu, G.; Katchman, A. N.; Zakharov, S. I.; Wan, E. Y.; Kalocsay, M.; Eisert, R.; Bradshaw, G. A.; Chen, B.; Yang, L.; Reiken, S.; Liao, X.; Ji, R.; Saadallah, N.; Fanourakis, S.; Topkara, V. K.; Yuan, Q.; Kushner, J.

10.1101/2025.05.08.652977 — cell biology — Posted on 2025-05-13

3801 The human-specific RPGR isoform RPGRs14/15 and the clinically approved Rho/ROCK inhibitor Ripasudil represent therapeutic options to address RPGR-associated defects.

Usman, M.; Atigbire, P.; Kastrati, D.; Brinkhoff, J. M.; Kluth, C.; Marticke, J.; Jueschke, C.; Neidhardt, J.

10.1101/2025.05.09.653106 — cell biology — Posted on 2025-05-13

3802 The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis

Thomalla, J. M.; Giedt, M. S.; White, R. P.; Wipf, I. J.; Shipley, A.; Welte, M. A.; Tootle, T. L.

10.1101/2025.05.09.653087 — cell biology — Posted on 2025-05-13

3803 p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic.

Long, K. R.; Singh, G.; Villemeur, M.; Brouwers, N.; Malhotra, V.; Raote, I.; Aridor, M.

10.1101/2025.05.07.652703 — cell biology — Posted on 2025-05-13

3804 Sodium valproate induces chromatin remodeling in U-251MG glioblastoma cells

Oliveira, C. B.; Rocha, M. A.; Mello, M. L. S.

10.1101/2025.05.09.653083 — cell biology — Posted on 2025-05-13

3805 Painless Nav1.7 mutations reveal function-critical residuesin the outer vestibule and N-terminus

Sarveswaran, N.; Drissi, I.; Shaikh, S.; Nahorski, M.; Cusdin, F.; Linley, J.; Woods, G.

10.1101/2025.05.12.653536 — molecular biology — Posted on 2025-05-13

3806 Recombinant protein platform for high-throughput investigation of peptide-liposome interactions via fluorescence anisotropy depolarization

Margaritakis, A.; Qian, M.; Johnson, D. H.; Zeno, W. F.; Ulmer, T. S.; Chung, P.

10.1101/2025.05.12.653516 — molecular biology — Posted on 2025-05-13

3807 LOXL2 alleviates post-traumatic knee osteoarthritis and pain

Ali, F.; Raut, R. D.; Choudhury, C.; Chakraborty, A. K.; Del Valle-Ponce De Leon, C.; Mehra, P.; Bais, M. V.

10.1101/2025.05.12.653521 — molecular biology — Posted on 2025-05-13

3808 LOXL2 Deletion Triggers TMJ Osteoarthritis While Overexpression Protects Against NF-κB-Induced Chondrocyte Apoptosis

Raut, R. D.; Choudhury, C.; Ali, F.; Chakraborty, A. K.; Ahmed, M. M.; Del Valle-Ponce De Leon, C.; Modh, H. V.; Mehra, P.; Fan, Y.; Almarza, A.; Bais, M. V.

10.1101/2025.05.12.653519 — molecular biology — Posted on 2025-05-13

3809 SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice

Anderson, K. A.; deSouza, B.; Castellano-Escuder, P.; Lin, Z.; Ilkayeva, O.; Muehlbauer, M. J.; Grimsrud, P.; Hirschey, M.

10.1101/2025.05.12.653532 — molecular biology — Posted on 2025-05-13

3810 MALDI-TIMS-MS2 Imaging and Annotation of Natural Products in Fungal-Bacterial Co-Culture

Sanchez, L.; Shepherd, R. A.; Luu, G. T.

10.1101/2025.05.11.653367 — microbiology — Posted on 2025-05-13

3811 The protective role of chloroplast NADH dehydrogenase-like complex (NDH) against PSI photoinhibition under chilling stress

Takeuchi, K.; Harimoto, S.; Che, Y.; Kumazawa, M.; Satoh, H.; Maekawa, S.; Miyake, C.; Ifuku, K.

10.1101/2025.05.11.653304 — plant biology — Posted on 2025-05-13

3812 The highly conserved aphid effector pair Mp1-Mp58 associates to form an effector complex that targets host trafficking protein VPS52

Bleau, J. R.; Gaur, N.; Waksman, T.; Fisher, S. R.; Porter, M.; Bos, J. I.

10.1101/2025.05.12.653458 — plant biology — Posted on 2025-05-13

3813 Extrinsic biological stochasticity and technical noise normalization of single-cell RNA sequencing data

Fang, M.; Pachter, L.

10.1101/2025.05.11.653373 — bioinformatics — Posted on 2025-05-12

3814 The Dynamic Nature of Genetic Risk for Schizophrenia Within Genes Regulated by FOXP1 During Neurodevelopment

Ali, D.; Donohoe, G.; Morris, D. W.

10.1101/2025.05.12.653444 — genomics — Posted on 2025-05-13

3815 Genetic basis of maneb-induced dopaminergic neurodegeneration in Drosophila

Villalobos-Cantor, S.; Arreola-Bustos, A.; Martin, I.

10.1101/2025.05.07.652747 — genetics — Posted on 2025-05-12

3816 The Functional and Genetic Architecture of Olfaction in Deer Mice

LASSANCE, J.-M.; Kautt, A. F.; Gozashti, L.; Hoekstra, H. E.

10.1101/2025.05.12.653383 — evolutionary biology — Posted on 2025-05-13

3817 Physiological mechanisms underlying coral acclimatization capacity to novel, multi-stressor conditions

Solomon, S. L.; Lippens, C. R.; Mazza, R.; Powell, M. E.; Johnson, K. W.; Suvacarov, S.; Van der Zande, R. M.; Schoepf, V.

10.1101/2025.05.08.652802 — ecology — Posted on 2025-05-12

3818 Proximity proteomics of primary cilia in human hypothalamic neurons

Macarelli, V.; Sroka, T. J.; Hansen, J. N.; Axelsson, U.; Mick, D. U.; Merkle, F. T.

10.1101/2025.05.11.653368 — cell biology — Posted on 2025-05-12

3819 Non-invasive mapping of the temporal processing hierarchy in the human visual cortex

Eickhoff, K.; Hillebrand, A.; Knapen, T.; de Jong, M. C.; Dumoulin, S. O.

10.1101/2025.05.12.653426 — neuroscience — Posted on 2025-05-12

3820 Cerebellar tDCS differentially modulates sensory inputs in somatosensory cortex and cerebellum.

Sanchez-Leon, C. A.; Cordones, I.; Jimenez-Diaz, A.; Cheron, G.; Medina, J. F.; Marquez-Ruiz, J.

10.1101/2025.05.12.653393 — neuroscience — Posted on 2025-05-13

3821 22q11 deletion selectively alters progenitor states and projection neuron identities in the developing cerebral cortex

Rukh, S.; Meechan, D. W.; Siggins, C.; Erwin, Z. D.; Baldo, G.; Peck, A.; Maynard, T. M.; LaMantia, A.-S.

10.1101/2025.05.12.653556 — neuroscience — Posted on 2025-05-13

3822 Cholinergic blockade reveals role for human hippocampal theta in encoding but not retrieval

Gedankien, T.; Kriegel, J.; Zabeh, E.; McDonagh, D.; Lega, B.; Jacobs, J.

10.1101/2025.05.12.653487 — neuroscience — Posted on 2025-05-13

3823 Developmental embedding of parvalbumin interneurons drives local and crosshemispheric prefrontal gamma synchrony

Offermanns, A.; Poepplau, J. A.; Hanganu-Opatz, I. L.

10.1101/2025.05.12.653375 — neuroscience — Posted on 2025-05-13

3824 Low-Cost Screening of Algae for Extreme Tolerance to pH, Temperature, Salinity, and Light

Barbara Saucedo, B.; Kang, K.; May, L.; Gupta, A.; do Espirito Santo, E.; Mayfield, S.; Dutra Molino, J. V.

10.1101/2025.05.12.653396 — microbiology — Posted on 2025-05-12

3825 Epithelium intrinsic zinc sensor controls immune homeostasis with gut microbes via regulation of Tuft cell lineage

Yunker, R.; Han, G.; Vasquez, J.; Baldaro, K.; Zhang, L.; Lee, S.; Vaishnava, S.

10.1101/2025.05.07.652635 — immunology — Posted on 2025-05-12

3826 HENMT1 restricts endogenous retrovirus activity by methylation of 3'-tRNA fragments

Steinberg, J. I.; Sertznig, H.; Desmarais, J. J.; Wilken, J.; Rubio, D.; Peacey, M.; Kinney, J. B.; Schorn, A. J.

10.1101/2025.05.12.650695 — molecular biology — Posted on 2025-05-12

3827 The La Crosse virus Gc head domain is a major determinant of virus dissemination and pathogenesis.

Dedvukaj, A.; Rondeau, N. C.; Lutchko, M. C.; Stapleford, K. A.

10.1101/2025.05.12.653523 — microbiology — Posted on 2025-05-12

3828 Mycobacterium tuberculosis partitions the Krebs cycle to persist under iron starvation

Serafini, A.; Garza-Garcia, A.; Sorze, D.; de Carvalho, L. P. S.; Manganelli, R.

10.1101/2025.05.12.653400 — microbiology — Posted on 2025-05-12

3829 An intercellular signaling pathway in the mouse retina connects Kv2.1, GLT-1, and nitric oxide synthase 1 to optic nerve regeneration

Gilbert, H.-y.; Li, Y.; Yuki, K.; Omura, K.; Walter, M.; Hanovice, N.; Yin, Y.; Huang, P.; Danbolt, N. C.; Liu, Z.; Tang, J.; Zhang, Q.; Aizenman, E.; Lippard, S. J.; Benowitz, L.; Rosenberg, P. A.

10.1101/2025.05.07.652294 — neuroscience — Posted on 2025-05-12

3830 Liver-Derived, Circulating Xanthine Oxidoreductase Drives Vascular Impairment Associated with Inhalation of Ultrafine Particulates.

Williams, X. M.; Bossert, A. T.; Seman, M.; Lewis, S. E.; McCallen, H.; Pilkerton, J.; Bowdridge, E. C.; Paternostro, M. A.; Goldsmith, W. T.; Nurkiewicz, T. R.; Hussain, S.; Kelley, E. E.; DeVallance, E.

10.1101/2025.05.07.652261 — physiology — Posted on 2025-05-12

3831 Enteropancreatic neurons drive the glucoregulatory response to ingested lipid

10.1101/2025.05.09.652620 — physiology — Posted on 2025-05-12

3832 High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells

Lee, J. L.; Song, J.; Amor, R.; Bolton, J.; Thompson, A.; Götz, J.; Padmanabhan, P.

10.1101/2025.05.08.652390 — pharmacology and toxicology — Posted on 2025-05-12

3833 Pregnant Dairy Heifers Express Influenza A Virus Receptors in the Mammary Gland

Baker, P. H.; Glendenning, L. M.; Oliveira, M. X. S.; Cobb, B. A.; Enger, B. D.; Langel, S. N.

10.1101/2025.05.08.652757 — pathology — Posted on 2025-05-12

3834 Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features

Badenoch, B.; Fiehn, O.; Rappaport, N.; Srivastava, P.; Watanabe, K.; Chandrasekaran, S.; Miller, R. A.

10.1101/2025.05.11.651908 — bioinformatics — Posted on 2025-05-12

3835 Efficient evidence-based genome annotation with EviAnn

Zimin, A. V.; Puiu, D.; Pertea, M.; Yorke, J.; Salzberg, S.

10.1101/2025.05.07.652745 — bioinformatics — Posted on 2025-05-12

3836 P3ANUT: An enhanced DNA sequencing analysis platform for uncovering and correcting errors in peptide phage display library screening

Tucker, L.; Kolland, E.; Gooding, J.; Boudjelal, H.; Ahmadipour, S.; Field, R. A.; Warren, D. T.; Baker, D.; Ma, Y.; Marin, M. J.; Wu, T.; Morris, C. J.

10.1101/2025.05.12.648809 — bioinformatics — Posted on 2025-05-12

3837 Molecular dynamics simulations of intrinsically disordered protein regions enable biophysical interpretation of variant effect predictors

Zafar, A.; Hou, C.; Amirani, N.; Shen, Y.

10.1101/2025.05.07.652723 — bioinformatics — Posted on 2025-05-12

3838 Identification of HIV-Associated Gene Expression Biomarkers Using Machine Learning and Interpretable Artificial Intelligence

Mahmud, S.; Hossain, M. F.

10.1101/2025.05.08.652807 — bioinformatics — Posted on 2025-05-12

3839 Glycosylation-enabled Site-specific Growth Factor Engineering for Biomaterial Functionalization

Xing, Y.; Li, Q.; Campbell, P. G.; Ren, X.

10.1101/2025.05.11.652418 — bioengineering — Posted on 2025-05-12

3840 A Two-Phase Fluid Structure Interaction Model of Mucociliary Clearance Driven by Cilium

Vishnu, K.; Subburaj, K.; Colombo, M.

10.1101/2025.05.07.652624 — bioengineering — Posted on 2025-05-12

3841 Mechanistic insights into Enterocin C targeting the undecaprenyl phosphate recycling protein BacA

Folcher, V.; Auger, R.; Louche, C.; Serror, P.; Touze, T.

10.1101/2025.05.12.652377 — biochemistry — Posted on 2025-05-12

3842 Structure and inhibition mechanism of the helicase-primase complex from human herpesvirus 1

Sato, K.; Ishida, H.; Miyagishi, T.; Kobayashi, S.; Kise, Y.; Hamada, K.; Okada, C.; Oguni, A.; Nureki, O.; Kono, H.; Fukuzawa, K.; Sengoku, T.

10.1101/2025.05.12.653380 — biochemistry — Posted on 2025-05-12

3843 Structural mechanism of insulin receptor activation by a dimeric aptamer agonist

Kim, J.; Na, H.; Choi, S.-Y.; Oh, E. J.; Lee, H.; Ryu, S. H.; Yunn, N.-O.; Cho, Y.

10.1101/2025.05.12.653381 — biochemistry — Posted on 2025-05-12

3844 BMDD: A Probabilistic Framework for Accurate Imputation of Zero-inflated Microbiome Sequencing Data

Zhou, H.; Chen, J.; Zhang, X.

10.1101/2025.05.08.652808 — genomics — Posted on 2025-05-12

3845 Two high-quality rose genomes underpin a novel Rosa pangenome to advance rose genomics, phylogenetics, and breeding

Yang, Z.; Schijlen, E. G. W. M.; Schranz, E.; Zwaan, B. J.; de Ridder, D.; Visser, R. G. F.; Arens, P. F. P.; Smulders, M. J. M.; van Velzen, R.; Keurentjes, J. J. B.; Bourke, P. M.; Smit, S.

10.1101/2025.05.07.652600 — genomics — Posted on 2025-05-12

3846 Untangling the effects of within-host and between-host natural selection in viruses with applications to evolution of HIV-1 co-receptor usage

Drake, K.; Franceschi, V. B.; Nascimento, F. F.; Volz, E. M.

10.1101/2025.05.08.652803 — evolutionary biology — Posted on 2025-05-12

3847 Unearthing the rhizosphere microbiome recruited by ancestral bread wheat landraces

HERNANDEZ SORIANO, M. C.; Warren, F. J.; Hildebrand, F.; Wingen, L. U.; Miller, A. J.; Griffiths, S.

10.1101/2025.05.08.652585 — ecology — Posted on 2025-05-12

3848 RNA Pol I activity maintains chromatin condensation and the H3K4me3 gradient essential for oogenesis, independent of ribosome production

Mejia-Trujillo, R.; Zhao, Q.; Rahman, A.; Sarinay Cenik, E.

10.1101/2025.05.07.652530 — developmental biology — Posted on 2025-05-12

3849 Pln1 Mediates Lipid Droplet-Vacuole Tethering During Microlipophagy Saccharomyces cerevisiae

Monala Rao, J.; Folger, B.; Reus, J.; Toulmay, A.; Li, J.; Zhang, R.; Prinz, W.; Goodman, J.; Wang, F.

10.1101/2025.05.07.652694 — cell biology — Posted on 2025-05-12

3850 Targeting AASS improves neurotoxicity and mitochondrial function in astrocyte models for pyridoxine dependent epilepsy

Schuurmans, I. M. E.; Engelke, U.; Abedrabbo, M.; Puvogel, S.; Mijdam, R.; Scholten, G.-J.; van Katwijk, S. B.; Oudakker, A.; Al-Shekaili, H. H.; Lefeber, D. J.; Leavitt, B. R.; van Karnebeek, C. D. M.; Nadif Kasri, N.; Garanto, A.

10.1101/2025.05.07.652392 — cell biology — Posted on 2025-05-12

3851 RABEP1 amplifies front signaling in neutrophil migration

Kim, D. H.; Syahirah, R.; Zheng, C.; Ding, C.; Liu, S.; Wan, J.; Deng, Q.

10.1101/2025.05.08.652481 — cell biology — Posted on 2025-05-12

3852 Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle delivery

Iyer, S.; Daman, K.; Sun, Y.; Tutto, A.; Holbrook, S.; Joynt, A.; Yan, J.; Ambegaokar, P.; Guo, D.; Liu, P.; Stauffer, J.; Lee, S.; Gallagher, T.; Cox, G. A.; Keeler, A. M.; Siegwart, D. J.; Emerson, C. P.; Wolfe, S. A.

10.1101/2025.05.12.653518 — molecular biology — Posted on 2025-05-12

3853 Structural insights into the remodeled RNA polymerase II complex on an RNA template

Hao, J.; Qin, Z.; Ma, J.; Qu, J.; Wang, Y.; Folimonova, S. Y.; Liu, B.; Li, W.; Wang, Y.

10.1101/2025.05.12.653476 — molecular biology — Posted on 2025-05-12

3854 Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

Srivastava, S. P.; Zhou, H.; Shenoi, R.; Morris, M.; Lainez-Mas, B.; Takagaki, Y.; Ranjendran, B. K.; Setia, O.; Aryal, B.; Kanasaki, K.; Koya, D.; Inoki, K.; Dardik, A.; Fernandez-Hernando, C.; Shulman, G. I.; Goodwin, J. E.

10.1101/2025.05.08.652142 — molecular biology — Posted on 2025-05-12

3855 Identification and functional characterization of toluene degradation genes in Acinetobacter sp. Tol 5

Yoshimoto, S.; Hattori, M.; Inoue, S.; Mori, S.; Ohara, Y.; Hori, K.

10.1101/2025.05.12.653411 — microbiology — Posted on 2025-05-12

3856 Single-cell tracking of genetically minimized Salmonella reveals mechanisms of effector gene cooperation.

Burford, W. B.; Dilabazian, H.; Alto, L. T.; Ma, D. H.; Mobley, A. B.; Farrar, D.; Radhakrishnan, A.; Alto, N. M.

10.1101/2025.05.12.653496 — microbiology — Posted on 2025-05-12

3857 Bacteriophage replication strategies are associated with organic matter energy content on coral reefs

Varona, N. S.; Schellenberg, L.; Barnes, W.; Scholten, Y.; Haas, A. F.; Silveira, C.

10.1101/2025.05.12.653515 — microbiology — Posted on 2025-05-12

3858 Serpine1 plays a critical role in Th17 cell differentiation and psoriasis pathogenesis

Saimaier, K.; Xie, L.; Wang, C.; lv, J.; Liu, G.; Han, S.; Li, C.; Du, C.

10.1101/2025.05.08.652800 — immunology — Posted on 2025-05-12

3859 CD33 Epitope Editing Unlocks UM171-Expanded Cord Blood Grafts for AML Immunotherapy

Lehnertz, B.; Langouet, M.; Corneau, S.; MacRae, T.; Joe, M.; Schmidt, E. N.; Spinella, J.-F.; Mayotte, N.; Moore, S.; Tellechea, M. F.; Boivin, I.; Papineau, L.; Rojas-Sutterlin, S.; Tual, M.; Jimenez Cortes, C.; Chagraoui, J.; Tomellini, E.; Desse, V.; Gagnon, E.; Macauley, M. S.; Sauvageau, G.

10.1101/2025.05.07.652621 — immunology — Posted on 2025-05-12

3860 Differences between human male and female neutrophils with respect to which RNAs are present in polysomes

Pilling, D.; Consalvo, K. M.; Kirolos, S. A.; Gomer, R. H.

10.1101/2025.05.07.652701 — immunology — Posted on 2025-05-12

3861 CaMK2rep: A Highly Sensitive Genetically Encoded Biosensor for Monitoring CaMKII Activity in Mammalian Cells

Martinez-Blanco, E.; de Andres, R.; Baratas-Alvarez, L.; Diez-Guerra, F. J.

10.1101/2025.05.07.652623 — neuroscience — Posted on 2025-05-12

3862 Statistical learning drives anticipatory micro-saccades toward suppressed distractor locations

Chen, S.; Zhang, X.; Li, X.; Jensen, O.; Theeuwes, J.; Wang, B.

10.1101/2025.05.11.652318 — neuroscience — Posted on 2025-05-12

3863 Empirical evidence of the neuroactive potential of the gut on neurochemistry in the gut-brain axis in humans

Johnstone, N.; Cohen Kadosh, K.

10.1101/2025.05.07.652653 — neuroscience — Posted on 2025-05-12

3864 The influence of HIV sense and antisense transcripts on stochastic HIV gene expression and reactivation

Wiecek, K.; Wisniewski, J.; CHEN, H.-C.

10.1101/2025.05.07.652610 — systems biology — Posted on 2025-05-12

3865 Extensive Benchmarking of Community Detection Algorithms

R, S.; Karthik, H.; Raman, K.

10.1101/2025.05.07.652778 — systems biology — Posted on 2025-05-12

3866 The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.

Ortmayr, K.; Ringwald, M.; Schuhknecht, L.; Dubuis, S.; Paunossis, E.; Blasi, M.; Jehanno, C.; Grieder, S.; Bentires-Alj, M.; Mall, M.; Zampieri, M.

10.1101/2025.05.12.652188 — cancer biology — Posted on 2025-05-12

3867 Emergent Homeostasis and Degeneracy from multi-Dimensional Attractors

Salman, H.; Biswas, K.; Brenner, N.

10.1101/2025.05.07.652484 — biophysics — Posted on 2025-05-12

3868 The Impact of Exogenous Mutagens on Human Mitochondrial DNA Ploidy: Analysis of Changes and Possible Protective Mechanisms.

Van Leiden, N.; Potapova, N.; Ree, N.

10.1101/2025.05.09.648561 — bioinformatics — Posted on 2025-05-12

3869 Sex-Based Transcriptomic Differences in Psoriatic Lesions: A Comprehensive Meta-Analysis

Stemmer, E.; Salmon-Divon, M.; Sinberger, L. A.; Lax, T.; Shrem, G.; Mor, I.; Zahavi, T.

10.1101/2025.05.07.652611 — bioinformatics — Posted on 2025-05-12

3870 Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in M. tuberculosis clinical isolates

Ioerger, T. R.; Shatby, A.

10.1101/2025.05.07.652684 — bioinformatics — Posted on 2025-05-12

3871 Ultrasonically Powered Neuromodulation Platform Intended for Spatially and Directionally Selective Electrical Stimulation

Kolovou Kouri, K.; Holzapfel, L.; Ferreira Dias, D.; Meixner, L.; Serdijn, W. A.; Giagka, V.

10.1101/2025.05.07.652395 — bioengineering — Posted on 2025-05-12

3872 Modeling glenohumeral stability in musculoskeletal simulations: A validation study with in vivo contact forces

Hasan, I. M. I.; Belli, I.; Seth, A.; Gutierrez-Farewik, E. M.

10.1101/2025.05.08.652806 — bioengineering — Posted on 2025-05-12

3873 Spatial proteomics reveals lipid droplet reorganization in symbiotic Paramecium bursaria cells

Chen, Y.-J.; Kamal, M. M.; Hsu, C.-C.; Leu, J.-Y.

10.1101/2025.05.12.652804 — biochemistry — Posted on 2025-05-12

3874 Cenchrus purpureus and Cenchrus americanus repeatome provide chromosomal markers to distinguish subgenomes

Silvestrini, A. J. A.; Vaio, M.; Azevedo, K. C.; Torres, G. A.

10.1101/2025.05.10.652685 — genomics — Posted on 2025-05-12

3875 Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming

Stock, M.; Guillen-Angel, M.; Witzenberger, M.; Nowak, J.; Biela, A.; Chramiec-Glabik, A.; Mariano, V.; Dreos, R.; Sklias, A.; Quadroni, M.; Brummer, A.; Gallart-Ayala, H.; Ivanisevic, J.; Guex, N.; Kleenman, L.; Leidel, S.; Helm, M.; Bagni, C.; Glatt, S.; Gatfield, D.; Schwartz, S.; Roignant, J.-Y.

10.1101/2025.05.12.653498 — genetics — Posted on 2025-05-12

3876 Subcellular Mass Spectrometry Reveals Proteome Remodeling in an Asymmetrically Dividing (Frog) Embryonic Stem Cell

Shen, B.; Pade, L. R.; Zhou, F.; Nemes, P.

10.1101/2025.05.12.652541 — developmental biology — Posted on 2025-05-12

3877 In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.

Worthington, A. K.; Borges, B.; Lum, T.; Echeverri, E. S.; Zada, F. M.; Cordero, M.; Kim, H.; Zenhausern, R.; Celik, O.; Shaw, C.; Gutierrez-Martinez, P.; Omarova, M.; Blanchard, C.; Burns, S.; Cromer, K.; Dahlman, J.; MacKenzie, T.

10.1101/2025.05.12.652147 — cell biology — Posted on 2025-05-12

3878 Dynamic transcription pre-initiation complex assembly governs initiation efficiency

Haque, N.; Coleman, R. A.

10.1101/2025.05.07.652662 — cell biology — Posted on 2025-05-12

3879 Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system

Bai, B.; Li, J.; Wang, Z.; Yang, Y.; He, J.; Chen, G.; Zhang, Y.; Qi, Y.; Wan, Z.; Cai, L.; Wang, R.; Wang, K.; Zhao, D.; Zhang, J.; Huang, W.; Xu, R. X.; Sun, M.; Han, X.; Liu, Y.; Zhang, D.; Zhu, W.; Liu, J.; Guo, Y.

10.1101/2025.05.07.652597 — cell biology — Posted on 2025-05-12

3880 Osteocyte Differentiation Requires Glycolysis, But Mature Osteocytes Display Metabolic Flexibility

Prideaux, M.; Palmier, M.; Kitase, Y.; Bonewald, L. F.; OConnell, T. M.

10.1101/2025.05.09.652291 — cell biology — Posted on 2025-05-12

3881 SF3B1-targeted Splicing Inhibition Triggers Transcriptional Stress Response and Global Alterations in R-Loop Landscape

Castillo Guzman, D.; Hartono, S. R.; Frederick, M.; Sanz, L. A.; Sereiva, T.; Chedin, F.

10.1101/2020.06.08.130583 — molecular biology — Posted on 2025-05-12

3882 Ureaplasma parvum SMC-ScpAB complex is capable of loop extrusion and demonstrates properties that distinguish it from Bacillus subtilis homologue

Rumyantseva, N. A.; Sapozhnikova, A. P.; Khasanova, A. A.; Zapryagaeva, E. Y.; Kudryavtseva, M. A.; Morozova, N. E.; Vedyaykin, A.

10.1101/2025.05.11.653314 — molecular biology — Posted on 2025-05-12

3883 Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen Candida albicans

Menon, A. C. T.; Tebbji, F.; Alikashani, A.; Vincent, A. T.; Sellam, A.

10.1101/2025.05.12.653471 — microbiology — Posted on 2025-05-12

3884 Distribution and structural diversity of Type IV internal ribosome entry sites

Segar, K. E.; Sherlock, M. E.; Kieft, J. S.

10.1101/2025.05.12.653553 — microbiology — Posted on 2025-05-12

3885 Identification of host lncRNAs that impact Venezuelan equine encephalitis virus replication

Behnia, M.; Ye, C.; Somfleth, K.; Oyebamiji, O.; Brayer, K.; Guo, Y.; Ness, S.; Savan, R.; Bradfute, S. B.

10.1101/2025.05.12.653438 — microbiology — Posted on 2025-05-12

3886 Cytochrome c oxidase I deep amplicon sequencing for metabarcoding of equine strongyle communities: unexpectedly high Strongylus spp. burden in treated horses

Krücken, J.; Diekmann, I.; Andreotti, S.; Bredtmann, C. M.; Mbedi, S.; Sparmann, S.; Schmidt, J. S.; de Almeida Borges, F.; de Freitas, M. G.; Salle, G.; Hofer, H.; Matthews, J. B.; Tzelos, T.; Nielsen, M. K.; Kuzmina, T. A.; von Samson-Himmelstjerna, G.

10.1101/2025.05.12.653446 — microbiology — Posted on 2025-05-12

3887 Virion encapsidation and cell attachment function of the reovirus attachment protein is influenced by its structural flexibility

Garcia, M.; Danthi, P.

10.1101/2025.05.12.653539 — microbiology — Posted on 2025-05-12

3888 Prevalence, Production and the Role of Staphylococcus aureus Superantigens in Cystic Fibrosis Lung Disease.

Sun, Y.; Hu, B.; Chhabra, S.; Tolentino, J.; Suzuki, N.; Natarajan, J.; Harris, Z.; Stanley, G.; Bianco, C.; Planet, P. J.; Sherchand, S. P.; Adhikari, R.; Aman, J.; Zhang, X.; Koff, J. L.; Rajagopalan, G.

10.1101/2025.05.07.652658 — immunology — Posted on 2025-05-12

3889 Tissue resident memory T cells populate the human uveal tract

Foers, A. D.; Reekie, I. R.; Wickramasinghe, L.; Ward, A.; Buckley, T. M.; Attar, M.; Aguilar-Munoa, S.; Pilapil, Q.; Abdalla Elsayed, M. E.; Pledger, S.; Bhalla, A.; Hedley, R.; Hill, S.; Windell, D.; Barton, K.; Masood, I.; Lim, K. S.; Coles, M. C.; Sherlock, J. P.; Dick, A. D.; Coupland, S. E.; Sansom, S. N.; Copland, D. A.; Buckley, C. D.; Sharma, S. M.; ORBIT Consortium,

10.1101/2025.05.07.652385 — immunology — Posted on 2025-05-12

3890 Using FoxP2 to Distinguish Direct and Indirect Basal Ganglia Pathways for Vocal Learning in Songbirds

Jagannathan, A.; Nigudkar, M.; Bottjer, S.

10.1101/2024.12.08.627403 — neuroscience — Posted on 2025-05-12

3891 Population-Level Activity Dissociates Preparatory Overt from Covert Attention

Koevoet, D.; Voet, V.; Jones, H. M.; Awh, E.; Strauch, C.; Van der Stigchel, S.

10.1101/2025.05.07.652629 — neuroscience — Posted on 2025-05-12

3892 Multiplex Gene Editing Suppresses Random Integration of Hepatitis B Virus DNA in Chronically Infected Liver

Slattery, S.; Huo, W.; Arif, A.; Gordon, J.; Takeuchi, R.

10.1101/2025.05.06.652508 — bioengineering — Posted on 2025-05-12

3893 A GATA factor radiation in Caenorhabditis rewired the endoderm specification network

Darragh, A. C.; Weinstein, R.; Bloom, J. R.; Rifkin, S. A.

10.1101/2022.05.20.492851 — evolutionary biology — Posted on 2025-05-12

3894 Phase-specific premotor inhibition modulates leech rhythmic motor output

Radice, M.; Sanchez Merlinsky, A.; Yulita, F.; Szczupak, L.

10.1101/2024.12.03.626557 — neuroscience — Posted on 2025-05-12

3895 Control with Practical Guarantees of Stationary Variance in Stochastic Chemical Reaction Networks

M. Zand, A.; Gupta, A.; Khammash, M.

10.1101/2025.05.12.653489 — synthetic biology — Posted on 2025-05-12

3896 Multilayered regulation by RNA thermometers enables precise control of Cas9 expression

Phillips, E. K.; Klingeman, D. M.; Guss, A. M.; Eckert, C. A.; Alexander, W.

10.1101/2025.05.12.651296 — synthetic biology — Posted on 2025-05-12

3897 Ex vivo recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human Lymphoid Follicle Chip platform

Zhai, Y.; Ku, M. W.; Yang, K.; Patil, A.; Prabhala, P.; He, L.; Man, Y.; Spörri, S. B.; Gharpure, S.; Isaacs, A. R.; Ferdosi, S.; Pitek, A.; Maruggi, G.; Bertholet, S.; Firestone, J.; Mousavi, K.; Miller, E.; Luisi, K.; Hellman, C. A.; Williams, L. D.; Tomaras, G. D.; Yin, P.; Gygi, S.; McAuliffe, J.; Ingber, D. E.; Goyal, G.

10.1101/2025.04.16.649172 — immunology — Posted on 2025-05-12

3898 Mesolimbic dopamine ramps reflect environmental timescales

Floeder, J. R.; Jeong, H.; Mohebi, A.; K Namboodiri, V. M.

10.1101/2024.03.27.587103 — neuroscience — Posted on 2025-05-12

3899 Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown

Paterson, T.; Rohrs, J.; Hohman, T. J.; Mapstone, M.; Meikle, P.; Kaddurah-Daouk, R.; Levey, A. I.; Hood, L.; Funk, C. C.

10.1101/2024.07.23.604835 — neuroscience — Posted on 2025-05-12

3900 Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory

Alves, F. N. L.; Guerra, K. T. K.; Crestani, A. P.; Quillfeldt, J. A.

10.1101/2024.10.06.616911 — neuroscience — Posted on 2025-05-12

3901 Zebrafish as a model to study PERK function in developmental diseases: implications for Wolcott-Rallison syndrome

Almeida, L. M.; Lima, L. P.; Oliveira, N. A. S.; Silva, R. F. O.; Sousa, B.; Bessa, J.; Pinho, B. R.; Oliveira, J. M. A.

10.1101/2024.04.16.589737 — pharmacology and toxicology — Posted on 2025-05-12

3902 Anisotropic Cell Shape and Motion Coordinate Hindbrain Neuropore Morphogenesis

Perez-Verdugo, F.; Maniou, E.; Galea, G. L.; Banerjee, S.

10.1101/2024.11.21.624679 — biophysics — Posted on 2025-05-12

3903 Opposing Nodal and Wnt signalling activities govern the emergence of the mammalian body plan

Dias, A.; Pascual-Mas, P.; Robertson, G.; Torregrosa-Cortes, G.; Stelloo, S.; Casani-Galdon, P.; Babin, S.; Romaniuk, Y.; Mayran, A.; Wehmeyer, A. E.; Garcia-Ojalvo, J.; McNamara, H. M.; Vermeulen, M.; Arnold, S. J.; Martinez Arias, A.

10.1101/2025.01.11.632562 — developmental biology — Posted on 2025-05-12

3904 Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

Seo, S.; Ahn, Y.-O.; Patil, S. L.; Armetta, J.; Saturne, M. D.; Hegewisch-Solloa, E.; Guilz, N. C.; Patel, A.; Corneo, B.; Borowiak, M.; Mace, E. M.

10.1101/2023.09.25.559149 — cell biology — Posted on 2025-05-12

3905 An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Cattle, M. A.; Aguado, L. C.; Sze, S.; Wang, D. Y.; Papagiannakopoulos, T.; Smith, S.; Rice, C. M.; Schneider, W. M.; Poirier, J. T.

10.1101/2024.08.05.606586 — molecular biology — Posted on 2025-05-12

3906 Family life and cadmium ingestion independently shape offspring microbiomes in a subsocial insect

Cheutin, M.-C.; Honorio, R.; Meunier, J.

10.1101/2024.12.30.630762 — microbiology — Posted on 2025-05-12

3907 Commensal bacteria inhibit viral infections via a tryptophan metabolite

Jiang, D.; Soo, N.; Tan, C. Y.; Dankwa, S.; Wang, H.-Y.; Theriot, B. S.; Xue, K.; Hill, D.; Ardeshir, A.; Bain, J. R.; Heston, S. M.; Hurst, J. H.; Siddiqui, N. Y.; Van Rompay, K. K. A.; Cervantes-Barragan, L.; Smith, J. P.; Song, R.; Roper, J.; Kelly, M. S.; Hudgens, M. G.; De Paris, K.; Permar, S. R.; Goswami, R.; Surana, N. K.

10.1101/2024.04.21.589969 — microbiology — Posted on 2025-05-12

3908 Social rank-order stability of mice revealed by a novel food competition paradigm in combination with available space competition paradigms

Liu, M.; Chen, Y.; Chen, R.

10.1101/2024.10.15.618390 — neuroscience — Posted on 2025-05-12

3909 Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use

Barekat, K.; Ghosh, S.; Herrmann, C.; Keat, K.; Assenmacher, C.-A.; Tanes, C.; Wilson, N.; Sengupta, A.; Das, U. S.; Joshi, R.; Ritchie, M.; Bittinger, K.; Weljie, A.; Cadwell, K.; Bushman, F.; Wu, G.; FitzGerald, G. A.; Ricciotti, E.

10.1101/2024.11.22.624882 — pharmacology and toxicology — Posted on 2025-05-12

3910 De novo discovery of conserved gene clusters in microbial genomes with Spacedust

Zhang, R.; Mirdita, M.; Soeding, J.

10.1101/2024.10.02.616292 — bioinformatics — Posted on 2025-05-12

3911 A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

Ertekin, A.; Noronha, S. T.; Darko, C.; Massi, F.; Ryder, S. P.

10.1101/2025.05.09.653132 — biochemistry — Posted on 2025-05-12

3912 A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback

Treaster, M. J.; McCann, J.; Solovei, K. S.; Palmieri, R. J.; White, M. A.

10.1101/2025.04.28.650899 — genetics — Posted on 2025-05-12

3913 Chronic replication stress-mediated genomic instability disrupts placenta development in mice

Munisha, M.; Huang, R.; Khan, J.; Schimenti, J. C.

10.1101/2025.02.28.640689 — developmental biology — Posted on 2025-05-12

3914 Replicating the facilitatory effects of transcranial random noise stimulation on motion processing: A registered report

Edwards, G.; Ruhde, R.; Carroll, M. B.; Baker, C. I.

10.1101/2025.03.18.643903 — neuroscience — Posted on 2025-05-12

3915 Marine community metabolomes in the eastern tropical North Pacific Oxygen Deficient Zone reveal glycine betaine as a metabolic link between Prochlorococcus and SAR11

Kellogg, N. A.; Fuchsman, C. A.; Carlson, L. T.; Morris, R. M.; Ingalls, A. E.; Rocap, G.

10.1101/2025.05.07.652674 — systems biology — Posted on 2025-05-12

3916 Learning Biophysical Dynamics with Protein Language Models

Hou, C.; Zhao, H.; Shen, Y.

10.1101/2024.10.11.617911 — bioinformatics — Posted on 2025-05-12

3917 Aird-MSI: a high compression rate and decompression speed format for mass spectrometry imaging data

Li, S.; Sheng, H.; Du, P.; Chen, J.; Wang, X.; Tong, J.; Hong, J.; Jing, X.; Lu, M.; Yu, C.

10.1101/2025.05.07.652785 — bioinformatics — Posted on 2025-05-12

3918 The explosive radiation of the Neotropical Tillandsia subgenus Tillandsia (Bromeliaceae) has been accompanied by pervasive hybridization

Yardeni, G.; Barfuss, M. H. J.; Till, W.; Thornton, M. R.; Groot Crego, C.; Lexer, C.; Leroy, T.; Paun, O.

10.1101/2023.11.16.567341 — evolutionary biology — Posted on 2025-05-12

3919 Modelling PRRS transmission between pig herds in Denmark and prediction of interventions impact

Chang, Y.; Marques, A. R. P.; Fertner, M.; Toft, N.; Lorenzen, B.; Reimert, M. M.; Houe, H.; Conrady, B.

10.1101/2025.05.09.653077 — ecology — Posted on 2025-05-12

3920 Long non-coding RNA hsr-omega provides scaffolding for the nuclear domain B-body.

An, S.; Haque, S. N.; Adams, M.; Rodriguez, L. E. T.; Kiani, K.; Bryantsev, A.

10.1101/2025.05.07.652789 — cell biology — Posted on 2025-05-12

3921 Wall teichoic acids regulate peptidoglycan synthesis by paving cell wall microstructure

Barber, F.; Akbary, Z.; Yuan, Z.; Biboy, J.; Vollmer, W.; Rojas, E. R.

10.1101/2024.09.02.610702 — microbiology — Posted on 2025-05-12

3922 Poor sleep impairs immune responses and influenza vaccine protection

Guan, M.; Gu, W.; Abdelnaby, K.; Balamalaliyage, P.; Tunterak, W.; Li, M.; Wen, Y.; Driver, J.; Gozal, D.; Wan, X.-f.

10.1101/2025.05.07.652783 — immunology — Posted on 2025-05-12

3923 3BTRON: A Blood-Brain Barrier Recognition Network

Fletcher-Lloyd, N. V.; Bravo-Ferrer, I.; Gaasdal-Bech, K.; Diaz Castro, B.; Barnaghi, P.

10.1101/2025.02.12.637854 — neuroscience — Posted on 2025-05-12

3924 Multi-layer encapsulation of plant protoplasts.

Grasso, M. S.; Floreani, R.; Lintilhac, P. M.

10.1101/2025.05.08.652860 — plant biology — Posted on 2025-05-12

3925 Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence

Hawes, S.; Liang, B.; Oldham, B.; Sullivan, B. T.; Song, B.; Chang, L.; Wang, L.; Lin, D.-T.; Cai, H.

10.1101/2025.02.28.640838 — neuroscience — Posted on 2025-05-12

3926 Ciliary ARL13B is essential for body weight regulation in adult mice

Terry, T. T.; Gigante, E. D.; Alexandre, C. M.; Brewer, K. M.; Yue, X.; Berbari, N. F.; Vaisse, C.; Caspary, T.

10.1101/2023.08.02.551695 — genetics — Posted on 2025-05-12

3927 Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection

Zhong, S.; Wang, R.; Gao, X.; Guo, Q.; Lin, R.; Luo, M.

10.1101/2025.01.16.633477 — bioengineering — Posted on 2025-05-12

3928 Vancomycin-resistant enterococci colonise the antibiotic-treated intestine by occupying overlapping but distinct nutrient- and metabolite-defined intestinal niches

King, O. G.; Yip, A. Y. G.; Horrocks, V.; Miguens Blanco, J.; Marchesi, J. R.; Mullish, B. H.; Clarke, T. B.; McDonald, J. A. K.

10.1101/2024.12.12.628149 — microbiology — Posted on 2025-05-12

3929 The zoo of the gene networks capable of pattern formation by extracellular signaling

Anhom, K. M.; Ciudad, I. S.

10.1101/2025.05.06.652477 — systems biology — Posted on 2025-05-12

3930 Genomics of Root System Architecture Adaptation in Sorghum under Nitrogen and Phosphorus Deficiency

Magu, J.; Masanga, J.; Muui, C.; Runo, S.

10.1101/2025.05.07.652720 — genomics — Posted on 2025-05-12

3931 A human-specific regulatory mechanism revealed in a preimplantation model

Fueyo, R.; Wang, S.; Crocker, O. J.; Swigut, T.; Nakauchi, H.; Wysocka, J.

10.1101/2025.05.10.653263 — developmental biology — Posted on 2025-05-12

3932 Corn rust population genomics reveals a cryptic virulent group and adaptive effectorome

Li, Y.; Zhao, P.; Liu, X.; Tsui, C. K. M.; Croll, D.; Liang, j.; Cai, L.

10.1101/2025.05.07.652763 — molecular biology — Posted on 2025-05-12

3933 Visualization of extracellular polymeric substances in Aspergillus niger biofilms using fluorescent-labeled lectins.

Shailaja, A.; Bruce, T. F.; Gerard, P.; Kerrigan, J. L.

10.1101/2025.05.12.651018 — microbiology — Posted on 2025-05-12

3934 Unmasking Convergent Oxycodone Seeking and Consumption Driving Augmented Intake during Extended Access to Oral Operant Self-Administration

Sharp, B. M.; Chen, H.

10.1101/2025.05.07.652717 — neuroscience — Posted on 2025-05-12

3935 Adolescent cannabinoid vapour exposure sex-dependently alters the relationship between vulnerability traits and ethanol self-administration and modifies naltrexone actions on ethanol intake in rats

Acosta-Vargas, J.; De las Heras-Martinez, N.; Marcos, A.; Nozal, L.; Crego, A. L.; Ucha, M.; Higuera-Matas, A.

10.1101/2025.05.07.652663 — neuroscience — Posted on 2025-05-12

3936 Controllability analysis of macaque structural connectome from an edge centric perspective

Dey, S.; Bharti, E.; Deng, Z.-D.

10.1101/2025.03.07.642125 — neuroscience — Posted on 2025-05-12

3937 Combining structural modeling and deep learning to calculate the E. coli protein interactome and functional networks

Zhao, H.; Velez, C.; Naravane, A. C.; Saha, A.; Feldman, J.; Skolnick, J.; Murray, D.; Honig, B.

10.1101/2025.05.07.652715 — systems biology — Posted on 2025-05-12

3938 Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures

Ahmadkhani, N.; Sugden, C.; Mayo, A. T.; Higgins, A. Z.

10.1101/2025.05.07.652719 — pharmacology and toxicology — Posted on 2025-05-12

3939 Bridging 3D Molecular Structures and Artificial Intelligence by a Conformation Description Language

Xiong, J.; Shi, Y.; Zhang, W.; Zhang, R.; Chen, Z.; Zeng, C.; Jiang, X.; Cao, D.; Xiong, Z.; Zheng, M.

10.1101/2025.05.07.652440 — bioinformatics — Posted on 2025-05-12

3940 Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler

Maeda, A.; Ogata, K.; Ishihama, Y.

10.1101/2025.05.07.652599 — biochemistry — Posted on 2025-05-12

3941 Targeting C42 in PKGIα alleviates diastolic dysfunction in HFpEF

Su, J.; Zhang, M.; Yang, X.; Holt, M.; Raabe, J.; Cuello, F.; Shah, A. M.; Shattock, M. J.; Burgoyne, J. R.

10.1101/2025.05.09.653217 — biochemistry — Posted on 2025-05-12

3942 Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model

Usiello, A.; Arisumi, K.; Nuzzo, T.; Gilio, L.; Taniguchi, S.; Russo, R.; Motegi, H.; di Vito, R.; Hata, J.; Errico, F.; Hashiguchi, A.; Okano, H.; Furlan, R.; Finardi, A.; Bassi, M. S.; Nakahara, J.; Mita, M.; Kanai, T.; Chambery, A.; Yasui, M.; Centonze, D.; Sasabe, J.

10.1101/2025.05.07.652561 — neuroscience — Posted on 2025-05-12

3943 Retinal image motion distracts visual motion memory even when generated by eye movement

Miyamoto, T.; Numasawa, K.

10.1101/2025.05.07.652578 — neuroscience — Posted on 2025-05-12

3944 Cap-adjacent 2'-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1

Clemens, E.; Brivio, S.; Al-Khafaji, M.; Eijlers, P.; Kurukulasuriya, M.; MacLeod, D.; Haussmann, I.; Wenzel, M.; Mueller, B.; Soller, M.; Pettitt, J.

10.1101/2025.03.10.638824 — molecular biology — Posted on 2025-05-12

3945 Mapping the loss of flagellar motility across the tree of life

Philip, J. S.; Grewal, S.; Scadden, J.; Puente Lelievre, C.; Matzke, N. J.; McNally, L.; Baker, M. A.

10.1101/2024.12.05.626484 — microbiology — Posted on 2025-05-12

3946 Machine learning for optimal growth temperature prediction of prokaryotes using amino acid descriptors

Colette, S.; Francois, J.; De Moor, B.; van Noort, V.

10.1101/2025.03.03.640802 — microbiology — Posted on 2025-05-12

3947 AI-Driven Analysis Unveils Functional Dynamics of Müller Cells in Retinal Autoimmune Inflammation

Shi, G.; Nagarajan, V.; Caspi, R. R.

10.1101/2025.02.28.640907 — immunology — Posted on 2025-05-12

3948 A functionally validated TCR-pMHC database for TCR specificity model development

Messemaker, M.; Kwee, B. P. Y.; Moravec, Z.; Alvarez-Salmoral, D.; Urbanus, J.; de Paauw, S.; Geerligs, J.; Voogd, R.; Morris, B.; Guislain, A.; Mussmann, M.; Winkler, Y.; Steinmetz, M.; Iras, M.; Marcus, E.; Teuwen, J.; Perrakis, A.; Beijersbergen, R. L.; Scheper, W.; Schumacher, T.

10.1101/2025.04.28.651095 — immunology — Posted on 2025-05-12

3949 Nonlinear feedback modulation contributes to the optimization of flexible decision-making

Zhou, Y.; Wu, X.

10.1101/2023.07.15.549136 — neuroscience — Posted on 2025-05-12

3950 From static to dynamic: how object rotation influences grasp decisions in ambiguous settings

Maffitt, N. J.; Cairns, E. G.; Wozna, J.; Soteropoulos, D. S.; Kraskov, A.

10.1101/2023.11.20.567846 — neuroscience — Posted on 2025-05-12

3951 Direct quantitative assessment using digital droplet PCR and field-scale spatial distribution of Plasmopara viticola oospores in vineyard soil

Poeydebat, C.; Courchinoux, E.; Demeaux, I.; Rodriguez, M.; Chataigner, A.; Lelievre, M.; Goutouly, J.-P.; Rossi, J.-P.; Raynal, M.; Deliere, L.; Francois, D.

10.1101/2024.07.29.605284 — plant biology — Posted on 2025-05-12

3952 Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes

Yang, J.; de Oliveira Pessoa, D.; Ryniawec, J. M.; Coope, M. R.; Buster, D. W.; Loertscher, E.; Wang, M.; Chen, C.; Cress, A. E.; Rogers, G. C.; Padi, M.

10.1101/2025.05.10.653266 — cancer biology — Posted on 2025-05-12

3953 Uromodulin velcro sheets and their interaction with uropathogenic E. coli

Banjara, S.; Wang, H.; Schaeffer, C.; Stsiapanava, A.; Sandin, S.; Carroni, M.; Okumura, H.; Rampoldi, L.; Sandblad, L.; Jovine, L.

10.1101/2025.05.09.653020 — biophysics — Posted on 2025-05-12

3954 Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment

Zaza, C.; Joseph, M. D.; Dalby, O. P. L.; Walther, R. F.; Kolataj, K.; Chiarelli, G.; Pichaud, F.; Acuna, G. P.; Simoncelli, S.

10.1101/2024.08.26.609760 — biophysics — Posted on 2025-05-12

3955 Defective But Promising: Evaluating Bioinformatic Pipelines for Utility of Defective Interfering RNA Discovery in Plant Viral Infections

Taylor, A. A.; Rosa, C.; Archetti, M. A.

10.1101/2025.05.09.653214 — bioinformatics — Posted on 2025-05-12

3956 ScIsoX: A Multidimensional Framework for Measuring Isoform-Level Transcriptomic Complexity in Single Cells

Wu, S.; Schmitz, U.

10.1101/2025.04.28.650897 — bioinformatics — Posted on 2025-05-12

3957 The tricyclic antidepressant cyproheptadine rescues egg-laying defect of grk-2 mutants

Wang, J.

10.1101/2025.05.09.653175 — biochemistry — Posted on 2025-05-12

3958 Powerful one-dimensional scan to detect heterotic QTL

Li, G.; Schmidt, R. H.; Zhao, Y.; Reif, J. C.; Jiang, Y.

10.1101/2025.05.06.652159 — genetics — Posted on 2025-05-12

3959 Genetic association meta-analysis is susceptible to confounding by between-study cryptic relatedness

Tu, T.; Ochoa, A.

10.1101/2025.05.10.653279 — genetics — Posted on 2025-05-12

3960 Endosymbionts impact ladybird predation rates of aphids in a temperature-dependent manner

Bitsch, K.; Ross, P. A.; Gill, A.; Yang, Q.; Stelmach, M.; Callahan, A.; Oersted, M.; Hoffmann, A. A.; Kristensen, T. N.

10.1101/2024.09.20.614137 — ecology — Posted on 2025-05-12

3961 Elevated mitochondrial metabolism in Down syndrome iPSCs reduces commitment to neuroectoderm

Rothermel, B. A.; Chaklader, M.; Souza Bomfim, G. H.; Jeju, N.; Duan, Y.; Niemeyer, B. F.; Espinosa, J. M.; Rosado-Olivieri, E.; Lin, W.; Lacruz, R. S.

10.1101/2025.05.09.653211 — developmental biology — Posted on 2025-05-12

3962 Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

Hozumi, A.; Totsuka, N. M.; Onodera, A.; Wang, Y.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Hotta, K.; Sasakura, Y.

10.1101/2024.04.09.588679 — developmental biology — Posted on 2025-05-12

3963 MagnEspScope - DIY microscope with integrated magnetic system for magnetogenetic studies

Minin, A. S.; Belousova, A. V.; Zubarev, I.

10.1101/2025.05.10.653253 — cell biology — Posted on 2025-05-12

3964 miR-486-3p ameliorates aging-related impaired angiogenesis in adult moyamoya disease by targeting Forkhead Box O4

Chen, J.; Wen, Y.; Chen, S.; Long, T.; Chen, F.; Wang, Z.; Zhang, G.-Z.; Li, M.; Zhang, S.; Kang, H.; Feng, W.; Wang, G.

10.1101/2025.05.07.652777 — molecular biology — Posted on 2025-05-12

3965 Novel origin of replication for environmentally isolated Pantoea strain enables expression of heterologous proteins, pathways and products

Codik, A.; Kothari, A.; Liu, H.; Weinberg, B. L.; Owens, T. K.; Srinivasan, A.; Rivier, A.; Eng, T.; Arkin, A. P.; Deutschbauer, A. M.; Mukhopadhyay, A.

10.1101/2025.05.10.653210 — microbiology — Posted on 2025-05-12

3966 Phosphorylation of the α subunit inhibits proteasome assembly and regulates cell division in archaea

Huang, Q.; Wu, Y.; Gan, Q.; Liang, S.; Yang, Y.; Wu, P.; Feng, X.; She, Q.; Ni, J.; Shen, Y.

10.1101/2025.05.09.653063 — microbiology — Posted on 2025-05-12

3967 Promising Inhibitor of Flavivirus: Evaluating the Antiviral Activity of Nordihydroguaiaretic Acid against West Nile Virus Replication

Martinez, F.; Ghietto, L. M.; Lingua, G.; Aguilar, J. J.; Gil, P. I.; Gomez, T. I.; Marioni, J.; Nunez-Montoya, S. C.; Konigheim, B.

10.1101/2025.05.10.653272 — microbiology — Posted on 2025-05-12

3968 Decoding hypnotic consciousness: neural and experiential insights into induced and ideomotor suggestions

Gelebart, J.; Foure, A.; Quentin, R.; Debarnot, U.

10.1101/2025.05.11.652707 — neuroscience — Posted on 2025-05-12

3969 Psilocybin-induced modulation of visual salience processing

Muller, S. A.; Cavanna, F.; de la Fuente, L. A.; Bruno, N.; D'Amelio, T.; Pallavicini, C.; Tagliazucchi, E.

10.1101/2025.05.10.652897 — neuroscience — Posted on 2025-05-12

3970 From Noise to Models to Numbers: Evaluating Negative Binomial Models and Parameter Estimations in Single-Cell RNA-seq

Wang, Y.; Shu, Z.; Cao, Z.; Grima, R.

10.1101/2025.05.05.652189 — systems biology — Posted on 2025-05-12

3971 Gaming the Metrics? Bibliometric Anomalies and the Integrity Crisis in Global University Rankings

Meho, L. I.

10.1101/2025.05.09.653229 — scientific communication and education — Posted on 2025-05-12

3972 Neural Mechanisms Supporting Proactive Control

Feldman, R. L.; Quale, M.; Etzel, J. A.; Braver, T. S.

10.1101/2025.05.09.653198 — neuroscience — Posted on 2025-05-12

3973 Synaptic dynamics govern spatial integration in mouse visual cortex

Li, J. Y.; Cammarata, C. M.; Glickfeld, L. L.

10.1101/2025.05.11.653343 — neuroscience — Posted on 2025-05-12

3974 Hippocampal reactivation of planned trajectories is required for effective goal choice in an allocentric memory task

Gobbo, F.; Mitchell-Heggs, R.; Duszkiewicz, A. J.; Tse, D.; Garcia-Font, N.; Faillace, E.; Spooner, P. A.; Keshishian, A.; Schnitzer, M. J.; Schultz, S. R.; Morris, R. G.

10.1101/2025.05.10.653115 — neuroscience — Posted on 2025-05-12

3975 Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis

Michaut, A.; Chamolly, A.; ALEGRIA, O.; Phan, C.; Corson, F.; Gros, J.

10.1101/2025.05.11.653307 — developmental biology — Posted on 2025-05-12

3976 Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy

Vermudez, S. A. D.; Freitas, G. A.; Smith, M.; Gogliotti, R.; Niswender, C. M.

10.1101/2025.05.08.652716 — neuroscience — Posted on 2025-05-12

3977 BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons

Gazal, N. G.; Castellanos-Montiel, M. J.; Bruno, G.; Franco-Flores, A. K.; Lepine, S.; Gursu, L.; Haghi, G.; Maussion, G.; Anastasia, A.; Bisbal, M.; Gorostiza, E. A.; Durcan, T. M.; Unsain, N.

10.1101/2025.05.09.653215 — neuroscience — Posted on 2025-05-12

3978 Predicting cochlear synaptopathy in mice with varying degrees of outer hair cell dysfunction using auditory evoked potentials

Buran, B. N.; Elkins, S.; He, W.; Bramhall, N. F.

10.1101/2025.05.09.653157 — neuroscience — Posted on 2025-05-12

3979 Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Mimoso, T.; Korobeinikov, A.; Stein, A.; Milovanovic, D.; Rizzoli, S. O.; Köster, S.; Reshetniak, S.

10.1101/2025.05.08.652815 — neuroscience — Posted on 2025-05-12

3980 Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns

Speckert, A.; Gianinazzi, L.; Kollmorgen, S.; Hagmann, C.; Grehten, P.; Kottke, R.; Natalucci, G.; Latal, B.; Knirsch, W.; Tuura, R.; Spina Bifida Study Group Zurich, ; Hoefler, T.; Jakab, A.

10.1101/2025.05.08.652584 — neuroscience — Posted on 2025-05-12

3981 Spatially Organized IGF1 mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational Programs

Xu, J.; Lissit, K.; Huo, D.; Eacker, S. M.; Zhang, S.; Yang, A.; Huang, Y.; Dawson, T.; Dawson, V. L.

10.1101/2025.05.08.652851 — neuroscience — Posted on 2025-05-12

3982 Neurochemical imaging reveals changes in dopamine dynamics with photoperiod in a seasonally social vole species

Mun, J.; Power, K. C.; Beery, A. K.; Landry, M. P.

10.1101/2025.05.11.652581 — neuroscience — Posted on 2025-05-12

3983 LINKING MULTI-SCALE BRAIN CONNECTIVITY WITH VIGILANCE, WORKING MEMORY, AND BEHAVIOR IN ADOLESCENTS

Bajracharya, P.; Ballem, R.; Chen, J.; Camazon, P. A.; Khasayeva, N.; Calhoun, V.; Liu, J.; Iraji, A.

10.1101/2025.05.09.653144 — neuroscience — Posted on 2025-05-12

3984 Resting state periodic and aperiodic brain oscillations from birth to preschool years: Aperiodic maturity predicts developmental course

Green, H. L.; Edgar, J. C.; Mol, K.; McNamee, M.; Prosser, L.; Kim, M.; Kuschner, E. S.; Miller, G. A.; Chen, Y.

10.1101/2025.05.11.653151 — neuroscience — Posted on 2025-05-12

3985 Could instructor talk drive CURE effectiveness? A comparative study of instructor talk in introductory lab courses

Zajic, C. J.; Subramanian, K.; Adulla, A.; Allen, Z.; Blitchington, M. B.; Brotzman, A.; Carrillo, E.; Dhruv, J.; Evans, T.; Haider, S.; Han, S. A.; Hilton, L.; Holliday, K.; Keairnes, E.; Kum, J.; Lantz, W. N.; Martin, J.; Pierce-Tomlin, M.; Plunkett, M. J.; Sam, C. S.; Sarr, F.; Shroyer, A.; Tucker, C.; Walton, K.; West, M. A.; Wolfson, E.; Yoon, B.; Zumbro, K.; Dolan, E. L.

10.1101/2025.05.09.653137 — scientific communication and education — Posted on 2025-05-12

3986 An All-In-One Software Solution for Automated Processing of LA-ICP-TOF-MS datasets

Crawford, A. M.; Zee, D. Z.; Jin, Q.; Sue, A.; Sinha, N.; Ahn, S. H.; MacRenaris, K. W.; O'Halloran, T.

10.1101/2025.05.09.653091 — scientific communication and education — Posted on 2025-05-12

3987 A phrenic-sparing cephalic reanastomosis model: Acute effects and implications

Lebenstein-Gumovski, M.; Zharchenko, A.; Rasueva, T.; Sobol, E.; Petrov, P.; Eskov, K.

10.1101/2025.05.06.652103 — bioengineering — Posted on 2025-05-12

3988 Modelling PRRS transmission between pig herds in Denmark and prediction of interventions impact

Chang, Y.; Marques, A. R.; Fertner, M.; Toft, N.; Lorenzen, B.; Reimert, M. M.; Houe, H.; Conrady, B.

10.1101/2025.05.09.653077 — ecology — Posted on 2025-05-12

3989 Ex Vivo Removal of CD41 positive platelet microparticles from Plasma by a Medical Device containing a Galanthus nivalis agglutinin (GNA) affinity resin

de Necochea Campion, R.; Pesqueira, M.; LaRosa, S. P.

10.1101/2025.05.09.652772 — immunology — Posted on 2025-05-11

3990 Sleep stage-specific effects of 0.75 Hz phase-synchronized rTMS and tACS on delta frequency activity during sleep

Takahashi, K.; Kuo, M.-F.; Nitsche, M. A.

10.1101/2025.05.09.653171 — neuroscience — Posted on 2025-05-11

3991 Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium

Han, L. K. M.; Toenders, Y. J.; Shen, X.; Milaneschi, Y.; Whalley, H. C.; Saemann, P. G.; Andlauer, T. F. M.; Bauer, J.; Berger, K.; Borgers, T.; Cole, J. H.; Dannlowski, U.; Flinkenfluegel, K.; Grabe, H. J.; Grotegerd, D.; Gruber, O.; Hahn, T.; Hamilton, P. J.; Hatton, S. N.; Hermesdorf, M.; Hickie, I.; Homann, J.; Kircher, T. T. J.; Kraemer, B.; Kraus, A.; Krug, A.; Lill, C. M.; Medland, S. E.; Meinert, S.; Panzenhagen, A. C.; Penninx, B. W. J. H.; van der Wee, N. J. A.; van Tol, M.-J.; Volker, U.; Volzke, H.; Weihs, A.; Wittfeld, K.; Thomopoulos, S. I.; Jahanshad, N.; Thompson, P. M.; Pozzi

10.1101/2025.05.09.653064 — neuroscience — Posted on 2025-05-11

3992 Structural Covariance Network Properties Predictive of Early Adolescent Alcohol Initiation

Byrne, H.; Visontay, R.; Devine, E. K.; Wade, N. E.; Jacobus, J.; Squeglia, L. M.; Mewton, L.

10.1101/2025.05.08.652983 — neuroscience — Posted on 2025-05-11

3993 The illusion of stability in long-lived species: Poor early-life survival threatens the persistence of Giant Aldabra tortoise populations.

Lavigne, A. M.; Bullock, R.; Hemmings, N.

10.1101/2025.05.07.652633 — zoology — Posted on 2025-05-11

3994 Supra-resonant wingbeats in insects

Wold, E.; Yang, R.; Lynch, J.; Liu, E.; Gravish, N.; Sponberg, S.

10.1101/2025.05.07.652680 — zoology — Posted on 2025-05-11

3995 UniCell: Towards a Unified Solution for Cell Annotation, Nomenclature Harmonization, Atlas Construction in Single-Cell Transcriptomics

Hu, L.; Chen, Q.; Qiu, P.; Qin, H.; Zhang, Y.; Cao, L.; Xia, T.; Deng, Z.; Zhang, Y.; Fang, S.; Li, Y.

10.1101/2025.05.06.652331 — bioinformatics — Posted on 2025-05-11

3996 Magnetic Resonance Imaging for Improved Brain Tumor Detection

Benyard, B. A.; Soni, N.; Swain, A.; Srivastava, N.; Khokhar, S.; Yehya, N.; Fan, Y.; Kumar, D.; Nanga, R. P. R.; Frenneaux, M. P.; Haris, M.; Reddy, R.

10.1101/2025.05.06.652446 — bioengineering — Posted on 2025-05-11

3997 No evidence of sexually antagonistic coevolution in Drosophila reproductive tract transcriptomes

Thayer, R. C.; Polston, E. S.; Begun, D. J.

10.1101/2025.05.07.652506 — evolutionary biology — Posted on 2025-05-11

3998 Joint impact on thermotolerance of yeast species divergence in mitochondrial and nuclear genomes

Wang, J. T. J.; Ng, P. L. P.; Powers, M. E.; Brem, R. B.

10.1101/2025.05.07.652752 — evolutionary biology — Posted on 2025-05-11

3999 Mapping global fisheries climate risks to guide sustainable marine management

Faith, M. P.; Atkinson, A.; Heneghan, R. F.; Ostle, C.; Fernandes-Salvador, J. A.; Thompson, M. S. A.; Serra-Pompei, C.; Artioli, Y.; Schmidt, K.; Rees, S.; Holland, M.; McQuatters-Gollop, A.

10.1101/2025.05.07.652593 — ecology — Posted on 2025-05-11

4000 Shifting baselines increase the risk of misinterpreting biodiversity trends

Dellavalle, A.; Devenish, A. J. M.; Jarrett, C.; Annorbah, N. N. D.; Asamoah, A.; Boafo, K.; Lane, P. E.; Owen, J.; Morel, A. C.; Hulme, M. F.; Welch, A. J.; Norris, K.; Sanderson, F. J.; Tobias, J.

10.1101/2025.05.07.652594 — ecology — Posted on 2025-05-11

4001 The Freshwater Sounds Archive

Greenhalgh, J. A.; Akmentins, M.; Boullhesen, M.; Brejao, G. L.; Bowman, J. C.; Briers, R. A.; Campbell, k.; Clark, A.; Coen, M.; Desjonqueres, C.; Gaston, S.; Gottesman, B. L.; Jones, I. T.; Lahoz-Monfort, J. J.; Lindsay, E.; Rodriguez, F. M.; Navarrete-Mier, F.; Norton, M.; Las Casas e Novaes, M. C.; Okazaki, S.; Polajnar, J.; Ribeiro, M. C.; Roberts, L.; Rothenberg, D.; Sabet, S. S.; Satish, R.; Spriel, B.; Stankovic, D.; Velde, K. t.; Timperley, J. H.; Turlington, K.; Walker, J. R.; Valverde, M. P.; Cox, K.; Looby, A.

10.1101/2025.05.07.652412 — ecology — Posted on 2025-05-11

4002 Space use fidelity of non-territorial vulturine guineafowl groups is shaped by both environmental and social processes

Ogino, M.; Nyaguthii, B.; Papageorgiou, D.; Farine, D.

10.1101/2025.05.07.652762 — ecology — Posted on 2025-05-11

4003 Seasonal and developmental stage changes in exudate carbohydrate content shape the kelp microbiome

English, C.; Manoj, M.; Opalk, K.; Carlson, C. A.

10.1101/2025.05.07.652744 — ecology — Posted on 2025-05-11

4004 Urban bats change the menu: dietary plasticity across human-modified landscapes of a tropical island

Dietrich, M.; Wilkinson, D. A.; Le Minter, G.; Turpin, M.; Galan, M.; Charbonnel, N.; Dupuy, G.; Habchi-Hanriot, N.; Reynaud, B.; Delatte, H.; Lebarbenchon, C.

10.1101/2025.05.06.652573 — ecology — Posted on 2025-05-11

4005 Locus coeruleus-related insula activation supports implicit learning

Dahl, M. J.; Li, T.; Mather, M.; Werkle-Bergner, M.

10.1101/2025.05.10.653174 — neuroscience — Posted on 2025-05-11

4006 Exploiting nectar and blood feeding cues and phagostimulants to optimise Attractive Targeted Sugar Baits against a sand fly vector of leishmaniasis.

Castro, D. P.; Genta, F. A.; Rogers, M. E.

10.1101/2025.05.07.652609 — zoology — Posted on 2025-05-11

4007 Modulating cerebrospinal fluid dynamics using pulsed photobiomodulation: feasibility, parameter and skin-colour dependence

Motsenyat, A.; Zhong, X.; Van Lankveld, H.; Chen, J. X.; Mathew, A.; Chen, J. J.

10.1101/2025.05.06.652458 — physiology — Posted on 2025-05-11

4008 Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice

Bodmer, N. K.; Choudhury, M.; Mirza, H.; Yin, Y.; Mecham, R. P.; Brody, S. L.; Ornitz, D. M.; Koenitzer, J. R.

10.1101/2025.05.06.652563 — pathology — Posted on 2025-05-11

4009 Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting

Kumar, A.; Sanders, M.; Zhang, H.; Zhou, L.; Parveen, S.; Kelly, C. V.; Granneman, J. G.; Huang, Y.-m.

10.1101/2025.05.06.652485 — biophysics — Posted on 2025-05-11

4010 Multimodal Bonds Reconstruction Towards Generative Molecular Design

Wang, J.; Dokholyan, N. V.

10.1101/2025.05.06.652517 — bioinformatics — Posted on 2025-05-11

4011 Green Synthesis of a Novel Gelatin Crosslinked Oxidized Pullulan-Lignin biocomposite film for active food packaging

Althuri, A.; Banerjee, A.; Mehra, M. K.

10.1101/2025.05.06.652438 — bioengineering — Posted on 2025-05-11

4012 Multiplex Gene Editing Suppresses Random Integration of Hepatitis B Virus DNA in Chronically Infected Liver

Slattery, S.; Huo, W.; Arif, A.; Gordon, J.; Takeuchi, R.

10.1101/2025.05.06.652508 — bioengineering — Posted on 2025-05-11

4013 Multivalent Ligand-Protein Interactions Using Polymeric Lysosome-Targeting Chimeras (PolyTACs) Leads to Lysosome-Targeting Receptor-Independent Degradation of Transmembrane Proteins

Dutta, R.; Alp, Y.; Gupta, P.; Singh, B.; Thayumanavan, S.

10.1101/2025.05.06.652519 — bioengineering — Posted on 2025-05-11

4014 Characteristics predicting reduced penetrance variants in the high-risk cancer predisposition gene TP53

Fortuno, C.; Richardson, M. E.; Pesaran, T.; McGoldrick, K.; James, P. A.; Spurdle, A. B.

10.1101/2025.05.06.652567 — genetics — Posted on 2025-05-11

4015 Long-lasting coexistence of multiple asexual lineages alongside their sexual counterparts in a fungal plant pathogen

Abdalrahem, A.; Andrieux, A.; Becheler, R.; Duplessis, S.; Frey, P.; Marcais, B.; Stoeckel, S.; Halkett, F.

10.1101/2025.03.28.645883 — evolutionary biology — Posted on 2025-05-11

4016 Abiotic factors are the primary determinants of endemic Hawaiian Drosophila microbiome assembly

Medeiros, M. J.; Schoville, S. D.; Price, D. K.; Yew, J. Y.

10.1101/2025.05.06.652154 — ecology — Posted on 2025-05-11

4017 A versatile survey method for repeatedly monitoring individual road-kill

Sullivan, J. J.; Vattiato, G.; Niebuhr, C. N.

10.1101/2025.05.06.652546 — ecology — Posted on 2025-05-11

4018 Protection of double-Holliday junctions ensures crossing over during meiosis

Tang, S. M.; Hariri, S.; Bohn, R.; McCarthy, J. E.; Koo, J.; Pourhosseinzadeh, M.; Nguyen, E.; Liu, N.; Ma, C.; Lu, H.; Lee, M.; Hunter, N.

10.1101/2024.09.14.613089 — cell biology — Posted on 2025-05-11

4019 Unveiling Genomic Rearrangements in Engineered iPSC Lines by Optical Genome Mapping

Finlay, D.; Hor, P.; Goldenson, B. H.; Li, X.-H.; Murad, R.; Kaufman, D. S.; Vuori, K.

10.1101/2025.05.10.653237 — molecular biology — Posted on 2025-05-11

4020 Formation of the β-sheet at the extracellular opening of the intimin β-barrel domain is necessary for stability and efficient passenger secretion

Sarma Kandanur, S. P.; Breuer, L.; Renschler, F. A.; Schuetz, M. S.; Leo, J. C.

10.1101/2025.05.11.653311 — microbiology — Posted on 2025-05-11

4021 Peptide Driven Identification of TCRs (PDI-TCR) reveals dynamics and phenotypes of CD4 T cells in tuberculosis

Tippalagama, R.; Trevizani, R.; Chihab, L.; Chawla, A.; Fung, K.; Greenbaum, J.; Kearns, K.; De Silva, A.; Gunasinghe, W.; Perera, J.; Gunasekera, H.; Senevirathne, D.; Scriba, T.; Sette, A.; Arlehamn, C. L.; Burel, J.; Peters, B.

10.1101/2025.05.06.652535 — immunology — Posted on 2025-05-11

4022 HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis.

Brown, K.; Walsh, A.; Yennemadi, A. S.; Murphy, D. M.; Conolly, S.; O'Sullivan, M. P.; Basdeo, S.; O'Leary, S.; Leisching, G.; Keane, J.

10.1101/2025.05.09.653039 — immunology — Posted on 2025-05-11

4023 Idebenone Enhances the Early Microglial Response to Traumatic Brain Injury and Mitigates Acute Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways

Hwang, H.; Sarkar, C.; Piskoun, B.; Zhang, N.; Borcar, A.; Robertson, C. L.; Lipinski, M. M.; Yadava, N.; Goodfellow, M. J.; Polster, B. M.

10.1101/2025.05.06.652467 — neuroscience — Posted on 2025-05-11

4024 Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period

Pillutla, S. V.; Skoda, M. J.; Ishii, A.; Corenblum, M. J.; Montgomery, T.; Wene, P. V.; Menakuru, N.; Kraszewski, J. N.; Billheimer, D.; Winter, G. M.; Cowen, S.; Madhavan, L.

10.1101/2025.05.06.652460 — neuroscience — Posted on 2025-05-11

4025 Vessels hiding in plain sight: quantifying brain vascular morphology in anatomical MR images using deep learning

Gilmore, A.; Eshun, A. E.; Wu, Y.; Lee, A. Y.; Rokem, A.

10.1101/2025.05.06.652518 — neuroscience — Posted on 2025-05-11

4026 Histology to MRI registration quality of ex vivo human brain blocks fixed with solutions used in anatomy laboratories

Frigon, E.-M.; Gerin-Lajoie, A.; Fouquet, J. P.; Zeighami, Y.; Boire, D.; Dadar, M.; Maranzano, J.

10.1101/2025.05.06.652445 — neuroscience — Posted on 2025-05-11

4027 Cholinergic neuron circadian clock mediates RNA-binding protein function and contributes to ALS disease phenotypes

Tam, S. B.; Waldeck, N. J.; Wright, M.; Baker, E. M.; Kiskinis, E.; Bass, J.; Kalb, R. G.

10.1101/2025.05.06.652480 — neuroscience — Posted on 2025-05-11

4028 APOE4-induced patterned behavioral decline and neurodegeneration requires endogenous tau in a C. elegans model of Alzheimers disease

Pierce-Shimomura, J.; Cardona, E. A.; Wu, Z.; Bolton, B. M.; Sarinay Cenik, E.

10.1101/2025.05.06.652574 — neuroscience — Posted on 2025-05-11

4029 Oxytocin restores context-specific hyperaltruistic preference through moral framing

Zhang, H.; Ni, Y.; Li, J.

10.1101/2024.09.03.611034 — neuroscience — Posted on 2025-05-11

4030 Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health

Rowsthorn, E.; Sim, M. A.; O'Brien, W. T.; McDonald, S. J.; Franks, K.; Sinclair, B.; Chong, T. T.- J.; Yiallourou, S.; Cavuoto, M.; Vivash, L.; O'Brien, T. J.; Shao, X.; Wang, D. J. J.; Law, M.; Harding, I. H.; Pase, M. P.

10.1101/2025.05.06.652544 — neuroscience — Posted on 2025-05-11

4031 Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury

Zhang, X.; Zhou, S.; Tang, S.; Hou, X.; Cai, Y.; Hu, C.

10.1101/2025.05.06.652540 — neuroscience — Posted on 2025-05-11

4032 Kinesin-1 Autoinhibition Tunes Cargo Transport by Motor Ensembles

Bensel, B. M.; Previs, S. B.; Fagnant, P. M.; Trybus, K. M.; Walcott, S.; Warshaw, D. M.

10.1101/2025.05.06.652443 — biophysics — Posted on 2025-05-11

4033 Uromodulin velcro sheets and their interaction with uropathogenic E. coli

Banjara, S.; Wang, H.; Schaeffer, C.; Stsiapanava, A.; Sandin, S.; Carroni, M.; Okumura, H.; Rampoldi, L.; Sandblad, L.; Jovine, L.

10.1101/2025.05.09.653020 — biophysics — Posted on 2025-05-11

4034 Structural Basis for Retron Co-option of Anti-phage ATPase-nuclease

Li, H.; Wang, B.; Hoffman, R.; Hou, Y.-M.

10.1101/2025.05.10.653283 — biophysics — Posted on 2025-05-11

4035 High-throughput discovery of transmembrane helix dimers from human single-pass membrane proteins with TOXGREEN sort-seq

Anderson, S. M.; Choi, J.; Cushman, E. M.; Leander, M.; Raman, S.; Senes, A.

10.1101/2025.04.22.650048 — biophysics — Posted on 2025-05-11

4036 GeoFlow-V2: A Unified Atomic Diffusion Model for Protein Structure Prediction and De Novo Design

BioGeometry Team, T.; Tang, J.

10.1101/2025.05.06.652551 — bioinformatics — Posted on 2025-05-11

4037 Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver

Tong, C. Y.; Li, C.; Hurni, C.; Jacq, A.; Nie, X. Y.; Guy, C. R.; Suh, J. H.; Wong, R. K. W.; Merlin, C.; Naef, F.; Menet, J. S.; Jiang, Y.

10.1101/2025.04.03.647044 — bioinformatics — Posted on 2025-05-11

4038 Actin Branching Regulates Cell Spreading and Force on Talin, but not Activation of YAP

Villalobos, C.; Sadeghifar, A.; Maggiorani, J.; Delapena, J.; McDaniel, G.; Driscoll, T. P.

10.1101/2025.05.09.653153 — bioengineering — Posted on 2025-05-11

4039 Discovery of a DNA-based Optical Nanotube Sensor for Glucose Using Clustering and Deep Learning Algorithms

Rabbani, Y.; Bregy, J.; Rousseau, B.; Sajjadi, S. H.; De Benedittis, L.; Behjati, S.; Mouhib, M.; Dehury, S.; Boghossian, A.

10.1101/2025.05.06.652529 — bioengineering — Posted on 2025-05-11

4040 Structural features within precursor microRNA-20a regulate Dicer-TRBP processing

Liu, Y.; Harkner, C. T.; Westwood, M. N.; Munsayac, A.; Keane, S. C.

10.1101/2025.05.07.652689 — biochemistry — Posted on 2025-05-11

4041 DNA Wrapping by a Tetrameric Bacterial Histone

Hu, Y.; Schwab, S.; Qiu, K.; Zhang, Y.; Baer, K.; Reichle, H.; Panzera, A.; Lupas, A. N.; Hartmann, M. D.; Dame, R. T.; Alva, V.; Alvarez, B. H.

10.1101/2025.05.08.652872 — biochemistry — Posted on 2025-05-11

4042 Constructing a consensus serum metabolome

Chi, Y.; Mitchell, J.; Thapa, M.; Zheng, S.; Frohock, Z.; Li, Y.; Smirnov, A.; Du, X.; Li, S.

10.1101/2025.05.07.652782 — biochemistry — Posted on 2025-05-11

4043 ASBAR: an Animal Skeleton-Based Action Recognition framework. Recognizing great ape behaviors in the wild using pose estimation

Fuchs, M.; Genty, E.; Zuberbuehler, K.; Cotofrei, P.

10.1101/2023.09.24.559236 — animal behavior and cognition — Posted on 2025-05-11

4044 Diverse horizontally transferred cellulose biosynthesis gene clusters in Escherichia coli strains

Hosseinpourlamardi, S.; Labiba, S.; Li, L.; Dadvar, A.; Romling, U.

10.1101/2025.05.09.653004 — genomics — Posted on 2025-05-11

4045 RNA Helicase A promotes small RNA biogenesis and sorting in germ cells

Gaylord, O.; Brown, J. S.; Wu, W.-S.; Lee, H.-C.

10.1101/2025.05.11.653140 — genetics — Posted on 2025-05-11

4046 Competition, Mutualism, and Host Immune Control in a Cancer Microbiome

Abbasi, E.; Abbasi, A.; Akcay, E.

10.1101/2025.05.06.652496 — ecology — Posted on 2025-05-11

4047 Exploring the Dynamics of Follicle Development and Hormone Synthesis: The Role of Oxygen Tension in Rhesus Macaque Follicle Culture

Wang, K.; Wolf, S.; Zelinski, M.; Krieg, A.

10.1101/2025.05.06.652505 — developmental biology — Posted on 2025-05-11

4048 UNCOVERseq Enables Sensitive and Controlled Gene Editing Off-Target Nomination Across CRISPR-Cas Modalities and Systems

Kinney, K. J.; Jia, K.; Zhang, H.; Schmaljohn, E.; Osborne, T.; Thommandru, B.; Murugan, K.; Sanchez-Pena, A.; West, S.; Chen, S.; Codipilly, R.; Sturgeon, M.; Turk, R.; McNeill, M.; Behlke, M.; Jacobi, A. M.; Cromer, K.; Kurgan, G.

10.1101/2025.05.09.653165 — molecular biology — Posted on 2025-05-11

4049 53BP1/RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.

Makins, K.; Cisneros-Aguirre, M.; Lopezcolorado, F. W.; Stark, J. M.

10.1101/2025.05.08.652920 — molecular biology — Posted on 2025-05-11

4050 G-quadruplex stabilization induces DNA breaks in pericentromericrepetitive DNA sequences in B lymphocytes

Waisertreiger, I.; Ayele, K.; Elshaikh, M. H.; Barlow, J.

10.1101/2025.05.09.653134 — molecular biology — Posted on 2025-05-11

4051 Validation of Gentamicin and Streptomycin Stability for On-Orbit Microbial Monitoring

McKaig, J. M.; Carr, C. E.

10.1101/2025.05.11.653350 — microbiology — Posted on 2025-05-11

4052 Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase

Barbuti, M. D.; Skjennum, E. F.; Mebus, V. H.; Morales Angeles, D.; Hustad, M.; Marli, M. T.; Frees, D.; Kjos, M.

10.1101/2025.05.11.653310 — microbiology — Posted on 2025-05-11

4053 TurbOmics: a web-based platform for the analysis of metabolomics data using a multi-omics integrative approach

Barrero-Rodriguez, R.; Rodriguez, J. M.; Naake, T.; Huber, W.; Juarez-Fernandez, M.; R. Ramiro, A.; Vazquez, J.; Mastrangelo, A.; Ferrarini, A.

10.1101/2025.05.09.653072 — bioinformatics — Posted on 2025-05-11

4054 De novo design of peptides localizing at the interface of biomolecular condensates

Schneider, T. N.; Gil-Garcia, M.; Buehler, M. A.; Santos, L. F.; Faltova, L.; Guillen-Gosalbez, G.; Arosio, P.

10.1101/2025.05.09.653111 — biochemistry — Posted on 2025-05-11

4055 Concentration- and time-dependence of phosphorylation events stimulated by fibroblast growth factor-4 (FGF-4) in Rama 27 fibroblasts

Alsadum, M. M.; Su, D.; Yates, E. A.; Fernig, D. G.

10.1101/2025.05.09.652961 — biochemistry — Posted on 2025-05-11

4056 Time-resolved effects of cold atmospheric plasma on E. coli GW-AmxH19 transcriptome and proteome in an emulated wastewater environment

Zühlke, D.; Bernhardt, J.; Schneider, D.; Rielicke, J.; Sievers, S.; Hahn, V.; Bömeke, M.; Poehlein, A.; Albrecht, D.; Kolb, J. F.; Riedel, K.; Daniel, R.

10.1101/2025.05.08.652849 — microbiology — Posted on 2025-05-11

4057 Structural Covariance Network Properties Predictive of Early Adolescent Alcohol Initiation

Byrne, H.; Visontay, R.; Devine, E. K.; Wade, N. E.; Jacobus, J.; Squeglia, L. M.; Mewton, L.

10.1101/2025.05.08.652983 — neuroscience — Posted on 2025-05-11

4058 SBMLNetwork: a framework for standards-based visualization of biochemical models

Heydarabadipour, A.; Smith, L.; Hellerstein, J. L.; Sauro, H. M.

10.1101/2025.05.09.653024 — systems biology — Posted on 2025-05-11

4059 Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activation

Bello-Arroyo, E.; Rubio, B.; Mora, A.; Lopez-Olaneta, M.; Gomez-Salinero, J. M.; Ramos, L.; Sanchez-Cabezudo, C. G.; Camafeita, E.; Cusso, L.; Desco, M.; Joffin, N.; Le Coq, J.; Boskovic, J.; McGurk, K. A.; Ware, J. S.; Barton, P. J.; Vazquez, J.; Scherer, P. E.; Sabio, G.; Gomez-Gaviro, M. V.; Lara-Pezzi, E.

10.1101/2025.05.09.653054 — physiology — Posted on 2025-05-11

4060 Evaluating transboundary connectivity to support cross-border conservation between Canada and the United States

O'Brien, P.; Tapper, S.; Brown, M. G. C.; Brennan, A.; Mubareka, S.; Pither, R.; Bowman, J.

10.1101/2025.05.08.652483 — ecology — Posted on 2025-05-11

4061 Grape Expectations: Disentangling Environmental Drivers of Microbiome Establishment in Winegrowing Ecosystems

Floerl, L.; Schoenenberger, P.; Rienth, M.; Bokulich, N. A.

10.1101/2025.05.08.652874 — microbiology — Posted on 2025-05-11

4062 Monocyte single cell-type gene expression measured in peripheral blood by DIRECT LS-TA method: the ratio-based biomarkers of (IFI27/PSAP) showed superior performance than interferon score in triage patients with viral infection

Tang, N. L.-s.; Kwan, T.-K.; Huang, D.; Huang, J.; Wang, X.; Lui, G. C.; Ma, S.-L.; Leung, K.-S.

10.1101/2025.05.08.652590 — immunology — Posted on 2025-05-11

4063 Species-specific loss of genetic diversity and exposure of deleterious mutations following agricultural intensification

Nolen, Z. J.; Jamelska, P. K.; Lara, A. S. T.; Wahlberg, N.; Runemark, A.

10.1101/2024.10.07.616612 — genomics — Posted on 2025-05-11

4064 Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

Soto-Moreno, E. J.; Ali, N. N.; Kuller, F.; Nasufovic, V.; Frolikova, M.; Tepla, O.; Masata, J.; Trauner, D.; Patterson, A. A.; Arndt, H.-D.; Komrskova, K.; Zernicka-Goetz, M.; Glover, D. M.; Balboula, A. Z.

10.1101/2025.05.07.652730 — cell biology — Posted on 2025-05-11

4065 Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance

Liu, Y.; Bondarenko, A.; Zhang, H.; Luan, P.; Zhang, Q.; Wang, B.; Najam, S. S.; Liang, X.; Syed, A. A. S.; Sirakawin, C.; Lin, D.; Huang, S.; Konovalov, R.; Konopka, W.; Zhang, Z.; Zhang, Y.; Wu, S.; Jing, M.; Vinnikov, I. A.

10.1101/2024.07.02.601503 — neuroscience — Posted on 2025-05-11

4066 Altered intrinsic ignition dynamics linked to Amyloid-β and tau pathology in Alzheimer's disease

Patow, G. A.; Escrichs, A.; Martinez-Molina, N.; Ritter, P.; Deco, G.

10.1101/2024.03.29.587333 — neuroscience — Posted on 2025-05-11

4067 Adaptation invariant concentration discrimination in an insect olfactory system

Ling, D.; Zhang, L.; Saha, D.; Chen, A. B.; Raman, B.

10.1101/2023.05.10.540073 — neuroscience — Posted on 2025-05-11

4068 Transcription Factor (TF) validation using Dam-IT simultaneously captures genome-wide TF-DNA binding, direct gene regulation, and chromatin accessibility in plant cells

Hinckley, W. E.; Jack, A.; Li, A.; Frangos, S.; Pasquino, A.; Huang, S.-s. C.; Coruzzi, G. M.

10.1101/2025.05.06.652526 — systems biology — Posted on 2025-05-11

4069 A trans-acting enhancer lncRNA modulates androgen-dependent gene expression via sequence-specific interaction with the Androgen Receptor

Sultanov, R. I.; Suzdalenko, A.; Shnaider, P.; Zubkova, O.; Arapidi, G. P.

10.1101/2025.05.09.652846 — cancer biology — Posted on 2025-05-11

4070 Hematopoietic Stem Cells Modulate Tumor Immune-Environment to Target Triple-Negative Breast Cancer via Altering Mitochondrial Bioenergetics

Mallick, S.; Biswas, S.; Shenoy, S. P.; Bose, B.

10.1101/2025.05.07.652451 — cancer biology — Posted on 2025-05-11

4071 Enhancer-driven regulatory network of forebrain human development provides insights into autism

Jourdon, A.; Mariani, J.; Natu, A.; Wu, F.; Li, B.; Capauto, D.; Hagy, K. T.; Norton, S.; Tomasini, L.; Safi, A.; Amiri, A.; Schreiner, J.; Nguyen, C. K.; Nolan, N.; Nelson, M. P.; Ramos, D. M.; Ward, M. E. E.; Szekely, A.; McPartland, J. C.; Pelphrey, K.; Ventola, P.; Chawarska, K.; Gersbach, C. A.; Crawford, G. E.; Abyzov, A.; Vaccarino, F. M.

10.1101/2023.09.06.555206 — genomics — Posted on 2025-05-11

4072 When less is not more: Limits to the evolution of metabolic dependence in spatially structured microbial communities

Ramesh, D.; Fara, E.; Oschmann, F.; Ugolini, G. S.; Stocker, R.; van Vliet, S.; Ackermann, M.; Schubert, O. T.

10.1101/2025.05.09.651753 — evolutionary biology — Posted on 2025-05-11

4073 EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer

Kim, H.; Kim, D.-G.; Ha, S.; Jang, J.-Y.; Vitorino, F. N. d. L.; Gongora, J. M.; Kim, W.; Oh, Y.; Park, G.; Kang, H.; Im, S.-H.; Jung, C. K.; Kim, S.-Y.; Jung, I.; Won, J.-k.; Garcia, B. A.; Kim, S.-j.; Lee, K. E.; Ryu, J.-K.; Lee, C.-H.

10.1101/2025.05.06.652476 — molecular biology — Posted on 2025-05-11

4074 Locus coeruleus-related insula activation supports implicit learning

Dahl, M. J.; Li, T.; Mather, M.; Werkle-Bergner, M.

10.1101/2025.05.10.653174 — neuroscience — Posted on 2025-05-11

4075 Neural Correlates of Social Withdrawal and Preference for Solitude in Adolescence

Risner, M.; Stamoulis, C.

10.1101/2025.03.17.643680 — neuroscience — Posted on 2025-05-11

4076 Modeling and Design of PCL-Chitosan Bi-Layered Microspheres for Intravitreal Controlled Release

Chacin Ruiz, E. A.; Carpenter, S. L.; Swindle-Reilly, K. E.; Ford Versypt, A. N.

10.1101/2024.01.11.575289 — pharmacology and toxicology — Posted on 2025-05-11

4077 Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma

Phuong, D. J.; Ralston, C. Q.; Ezzat, T. M.; Ashe, C. S.; Armstrong, A. P.; Flesken-Nikitin, A.; Yamulla, R. J.; Nikitin, A. Y.; Schimenti, J. C.

10.1101/2025.03.10.642422 — cancer biology — Posted on 2025-05-11

4078 Non-Intestinal Microbial Signatures in Stool as Predictors of Cancer Immunotherapy Outcome

Kanaeva, V. A.; Olekhnovich, E. I.

10.1101/2025.05.07.652660 — bioinformatics — Posted on 2025-05-11

4079 Genome-wide association study reveals KCNQ3 gene as a risk factor for fear-related behavior in dogs and zebrafish

Kubinyi, E.; Sandor, S.; Tatrai, K.; Varga, Z.; Varga, Z. K.; Topal, J.; Varga, M.; Jonas, D.; Turcsan, B.

10.1101/2025.05.07.652122 — animal behavior and cognition — Posted on 2025-05-11

4080 Charitability, Compulsion, & the Cost of Control

Arroyo, L.; Liljeholm, M.

10.1101/2025.05.07.652768 — animal behavior and cognition — Posted on 2025-05-11

4081 When does sexual selection through mate choice deplete versus exaggerate genetic variation: is there a lek paradox?

Xu, K.; Servedio, M. R.

10.1101/2024.12.10.627784 — evolutionary biology — Posted on 2025-05-11

4082 Lack of Vector Competence in UK Culex pipiens molestus for Oropouche Virus

Pilgrim, J.; Sy, V. S.; Multeau, Q.; Komarasamy, T. V.; Kohl, A.; Blagrove, M. S.; Tanianis-Hughes, J.; Medlock, J.; Sanders, C.; Baylis, M.; Dietrich, I.

10.1101/2025.05.07.652619 — microbiology — Posted on 2025-05-11

4083 Neural Representation of Time across Complementary Reference Frames

Xu, Y.; Sartorato, N.; Dutriaux, L.; Bottini, R.

10.1101/2024.11.07.622453 — neuroscience — Posted on 2025-05-11

4084 Real time evaluation of the liver microcirculation by whole organ machine perfusion within an MRI system

Rai, Z. L.; Holroyd, N. A.; Magbagbeola, M.; Doganay, E.; Doyle, K.; Caselton, L.; Stili, A.; Stoyanov, D.; Walker-Samuel, S.; Davidson, B. R.

10.1101/2025.05.08.652602 — physiology — Posted on 2025-05-11

4085 CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants

Huang, J.; Yang, Z.; Yin, M.; Li, C.; Li, J.; Wang, Y.; Huang, L.; Liang, C.; He, F.; Li, M.; Han, R.; Jiang, Y.

10.1101/2024.12.29.630569 — bioinformatics — Posted on 2025-05-11

4086 CVAE-based Causal Representation Learning from Retinal Fundus Images for Age Related Macular Degeneration(AMD) Prediction

Kim, D.

10.1101/2025.02.13.638092 — bioengineering — Posted on 2025-05-11

4087 Lateralised modulation of posterior alpha oscillations by closed loop auditory stimulation during memory retention

Hebron, H.; Dimitrova, R.; Jaramillo, V.; Dijk, D.-J.; Violante, I. R.

10.1101/2025.05.07.652437 — neuroscience — Posted on 2025-05-11

4088 Localized Reactivity on Protein as Riemannian Manifolds: A Geometric and Quantum-Informed Basis for Deterministic, Metal-Aware Reactive-Site Prediction

Park, H.

10.1101/2025.04.29.651260 — bioinformatics — Posted on 2025-05-11

4089 Triple-N Dataset: Non-human Primate Neural Responses to Natural Scenes

Li, Y.; Liu, X.; Li, W.; Yang, J.; Gong, B.; Jin, W.; Gong, Z.; Wang, K.; Luo, J.; Zhao, Z.; Bao, P.

10.1101/2025.05.06.652408 — neuroscience — Posted on 2025-05-11

4090 Estimating the changing risks of low crop yield using non-stationary generalized Pareto distributions

Onogi, A.

10.1101/2025.05.10.653234 — plant biology — Posted on 2025-05-11

4091 Two long non-coding RNAs, SVALKA and SVALNA, regulate CBF1 and CBF3 via multiple mechanisms

Rosenkranz, I.; Mermet, S.; Zacharaki, V.; Kindgren, P.

10.1101/2025.05.09.653013 — plant biology — Posted on 2025-05-11

4092 Integrative analysis of plant responses to a combination of water deficit, heat stress and eCO2 reveals a role for OST1 and SLAH3 in regulating stomatal responses

Pelaez-Vico, M. A.; Sinha, R.; Ghani, A.; Lopez-Climent, M. F.; Joshi, T.; Fritschi, F. B.; Zandalinas, S. I.; Mittler, R.

10.1101/2025.05.07.652739 — plant biology — Posted on 2025-05-11

4093 Multi-layer encapsulation of plant protoplasts.

Lintilhac, P. M.; Grasso, M. S.; Floreani, R.

10.1101/2025.05.08.652860 — plant biology — Posted on 2025-05-11

4094 LLS-SevEst - Late leaf spot severity estimator. A machine learning approach to assessing Nothopassalora personata in peanut.

Herrador, T. A.; Migotti Scaglia, J.; Paredes, J. A.; Cazon, L. I.

10.1101/2025.05.07.652206 — plant biology — Posted on 2025-05-11

4095 bHLH35 mediates specificity in plant responses to multiple stress conditions

Sinha, R.; Zandalinas, S. I.; Pelaez-Vico, M. A.; Ghani, A.; Khan, M. A.; Induri, S. P.; Bereimipour, A.; Ghandour, T.; Ogden, A.; Huang, S.-S. C.; Azad, R.; Mendoza, D. G.; Joshi, T.; Fritschi, F. B.; Mittler, R.

10.1101/2025.05.07.652729 — plant biology — Posted on 2025-05-11

4096 POLYGALACTURONASES REGULATED BY AUXIN facilitate root cell elongation in Arabidopsis thaliana via pectin remodeling

Kubalova, M.; Kampova, A.; Vosolsobe, S.; Raabe, K.; Simonaviciene, B.; Benitez-Alfonso, Y.; Muller, K.; Medvecka, E.; Fendrych, M.

10.1101/2025.05.07.652666 — plant biology — Posted on 2025-05-11

4097 A Unique LHCE Light-Harvesting protein Family is involved in Photosystem I and II Far-Red Absorption in Euglena gracilis

Miranda-Astudillo, H.; Arshad, R.; Vega de Luna, F.; Aguilar-Gonzalez, Z.; Foret, H.; Feller, T.; Gervasi, A.; Nawrocki, W.; Counson, C.; Morsomme, P.; Degand, H.; Baurain, D.; Kouril, R.; Cardol, P.

10.1101/2025.05.07.652572 — plant biology — Posted on 2025-05-11

4098 PSII photoinhibition as a protective strategy against PSI photoinhibition: Maintaining PSI in an oxidized state by suppressing PSII activity under environmental stress

Takeuchi, K.; Harimoto, S.; Maekawa, S.; Miyake, C.; Ifuku, K.

10.1101/2025.05.06.652500 — plant biology — Posted on 2025-05-11

4099 3D X-ray microscopy lights up nanoparticles in plants

Kristensen, E. V.; Siracusa, F.; Pinna, A.; Ertem, I.; Szameitat, A.; Villanova, J.; Gao, X.; Schiefler, A.; Tobler, D. J.; Ghoshal, S.; Husted, S.; Mokso, R.

10.1101/2025.05.08.652794 — plant biology — Posted on 2025-05-11

4100 Imputation integrates single-cell and spatial gene expression data to resolve transcriptional networks in barley shoot meristem development

Demesa-Arevalo, E.; Dorpholz, H.; Vardanega, I.; Maika, J. E.; Pineda-Valentino, I.; Eggels, S.; Lautwein, T.; Kohrer, K.; Schnurbusch, T.; von Korff, M.; Usadel, B.; Simon, R.

10.1101/2025.05.09.653223 — plant biology — Posted on 2025-05-11

4101 The bivalent epigenetic regulator ULTRAPETALA1 promotes the Arabidopsis floral transition via recruitment of Polycomb histone methyltransferases for H3K27me3 deposition at the FLC locus

Xing, Q.; Shemyakina, E.; Tian, J.; Strotmann, V. I.; Anwar, A.; Li, X.; Xiong, Y.; Yang, T.; Zheng, Y.; Pu, L.; Stahl, Y.; Mueller-Xing, R.; Fletcher, J. C.

10.1101/2025.05.06.652514 — plant biology — Posted on 2025-05-11

4102 A 3D Modeling Framework for Quantifying Variation in Soybean Root Structure Architecture

Carpenter, J.; Bogati, S.; Wang, D.; Jung, J.

10.1101/2025.05.06.652473 — plant biology — Posted on 2025-05-11

4103 Transcriptomic and physiological responses of soybean plants subjected to a combination of water deficit and heat stress under field conditions

Sinha, R.; Pelaez-Vico, M. A.; Dhakal, S.; Ghani, A.; Myers, R.; Verma, M.; Shostak, B.; Ogden, A.; Krueger, C. B.; Costa Netto, J. R.; Zandalinas, S. I.; Joshi, T.; Fritschi, F. B.; Mittler, R.

10.1101/2025.05.07.652738 — plant biology — Posted on 2025-05-11

4104 Live-Exudation Assisted Phytobiome Cultromics System (LEAP-CS): A High-Throughput Cultromics System for Studying Plant-Microbiome Interactions through Non-Contact Metabolic Exchange.

Mazumder, M.; Pavagadhi, S.; Bhattacharya, R.; Mukherjee, A.; Majedi, S. M.; Tan, I. C. H.; Swarup, S.

10.1101/2025.05.07.652788 — plant biology — Posted on 2025-05-11

4105 Lead, a toxic metal, alters auxin-mediated root growth and gravitropic responses in maize and Arabidopsis

Hazelwood, O. S.; Delpit, G.; H.L, T. D.; Sparks, E. E.; Best, N. B.; Ashraf, M. A.

10.1101/2025.05.09.653208 — plant biology — Posted on 2025-05-11

4106 Structural insights into late-stage photosystem II assembly by Psb32

Bohn, S.; Lo, Y. K.; Lambertz, J.; Meier-Credo, J.; Fuertges, T.; Liauw, P.; Gasper-Schoenenbruecher, R.; Wiens, D.; Langer, J.; Hochberg, G.; Hofmann, E.; Rudack, T.; Nowaczyk, M. M.; Schuller, J.

10.1101/2025.05.08.652833 — plant biology — Posted on 2025-05-11

4107 Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer

Saini, P.; Mirji, G.; Bhat, S. A.; Muthumani, K.; Cassel, J.; Tang, H.-Y.; Tateno, H.; Zhang, R.; Shinde, R.; Abdel-Mohsen, M.

10.1101/2025.05.06.652455 — immunology — Posted on 2025-05-11

4108 A Foraging-Theory Based Model Captures The Full Spectrum of Human Behavioral Diversity in a Classic RL Task

Harrell, D.; Zid, M.; Laurie, V.-J.; Chen, C.; Grissom, N.; Darrow, D. P.; Ebitz, B. R.; Herman, A. B.

10.1101/2025.05.06.652482 — neuroscience — Posted on 2025-05-11

4109 Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Chen, H.; Cretu, C.; Trebilcock, A.; Evdokimova, N.; Babai, N.; Feldmann, L.; Leidner, F.; Benseler, F.; Mutschall, S.; Esch, K.; Kibedi, C. Z.; Pena, V.; Pape, C.; Grubmüller, H.; Strenzke, N.; Brose, N.; Wichmann, C.; Preobraschenski, J.; Moser, T.

10.1101/2025.05.10.653085 — neuroscience — Posted on 2025-05-11

4110 Arousal state fluctuations are a source of internal noise underlying age-related declines in speech intelligibility

Smith, S. S.; Sugai, J. A.; Polley, D. B.

10.1101/2025.05.09.653191 — neuroscience — Posted on 2025-05-11

4111 Locus coeruleus-related insula activation supports implicit learning

Dahl, M. J.; Li, T.; Mather, M.; Werkle-Bergner, M. J.

10.1101/2025.05.10.653174 — neuroscience — Posted on 2025-05-11

4112 Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology

Haghani, V.; Ali, S. M.; Cannizzaro, N.; Patil, M. M.; Sullivan, P. D. M.; Rehman, A.; Green, R.; Ben-Shalom, R.; LaSalle, J.; Zarbalis, K.

10.1101/2025.05.07.652681 — neuroscience — Posted on 2025-05-11

4113 Whole brain dimensional approach identifies shared and sex-specific networks of stress susceptibility in male and female mice.

Herrera Portillo, L.; Gallino, D.; Yee, Y.; Muir, J.; Devenyi, G. A.; Bagot, R. C.; Chakravarty, M.

10.1101/2025.05.10.653278 — neuroscience — Posted on 2025-05-11

4114 A theory and recipe to construct general and biologically plausible integrating continuous attractor neural networks

Claudi, F.; Chandra, S.; Fiete, I. R.

10.1101/2025.05.07.652608 — neuroscience — Posted on 2025-05-11

4115 Automated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics

Jarvinen, E.; Liu, X.; Varjosalo, M.; Keskitalo, S. E.

10.1101/2025.05.06.652407 — systems biology — Posted on 2025-05-11

4116 MettleRNASeq: Complex RNA-Seq Data Analysis and Gene Relationships Exploration Based on Machine Learning

Salles, S.; Brustolini, O.; Ciapina, L. P.; Ocana, K.

10.1101/2025.05.06.652387 — bioinformatics — Posted on 2025-05-10

4117 An evolutionary approach to predict the orientation of CRISPR arrays

Fehrenbach, A.; Mitrofanov, A.; Alkhnbashi, O.; Backofen, R.; Baumdicker, F.

10.1101/2025.05.09.653049 — bioinformatics — Posted on 2025-05-11

4118 Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution

Capeling, M.; Chen, B.; Aliar, K.; Penna, E.; Lopez, V. I.; Foo, C.; Rost, S.; Holokai, L.; Tong, X.; Philipps, D.; Sweet, C.; Li, J.; Chatterjee, S.; Skippington, E.; Modrusan, Z.; McGinnis, L. M.; Wei, R.; Keir, M.; Rozenblatt-Rosen, O.; Chen, M. B.

10.1101/2025.05.06.652311 — bioengineering — Posted on 2025-05-11

4119 An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis

O'Neill, A. G.; McCartney, M. E.; Wheeler, G. M.; Patel, J. H.; Sanchez-Ramirez, G.; Kollman, J. M.; Wills, A. E.

10.1101/2025.05.09.652712 — biochemistry — Posted on 2025-05-11

4120 Concurrent detection of chemically modified bases in yeast mitochondrial tRNAs by Nanopore direct RNA sequencing

Reinsch, J. L.; Garcia, D. M.

10.1101/2025.05.09.653160 — molecular biology — Posted on 2025-05-10

4121 Diversity Between but Not Within Microbial Communities Increases With the Diversity of Supplied Nutrients

Newbury, A.; Buckling, A.

10.1101/2025.05.10.653264 — microbiology — Posted on 2025-05-10

4122 The Parkinsons disease associated Leucine-rich repeat kinase 2 affects expression of Transferrin receptor 1 and phosphorylation of key signaling proteins in human iPSC-derived dopaminergic neurons

Funk, N.; Knab, F.; Munz, M.; Ott, T.; Gasser, T.; Biskup, S.

10.1101/2025.05.06.652393 — neuroscience — Posted on 2025-05-10

4123 Ultrasmall chemogenetic tags with group-transfer ligands

Vedagopuram, S.; Sindi, S. H.; Chaudhary, S. K.; Pergu, R.; Singh, P.; Karaj, E.; Fung, J. E.; Deb, A.; DeCarlo, S. J.; Mercer, J. A. M.; Yamada, K.; Rodriguez, D.; Liu, D. R.; Choudhary, A.

10.1101/2025.05.10.653252 — synthetic biology — Posted on 2025-05-10

4124 GWAs reveals SUBER GENE1-mediated suberization via Type One Phosphatases

Han, J.-P.; Lefebvre-Legendre, L.; Capitao, M. B.; Gully, K.; Shukla, V.; Wu, Y.; Nawrath, C.; Barberon, M.

10.1101/2025.05.06.652434 — plant biology — Posted on 2025-05-10

4125 Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces

Zikai, G.; Lijuan, M.; Hang, F.; Chenguang, Y.; Dongfei, M.; Hongtao, Z.; Yumei, W.; Dapeng, S.; Shuxin, H.; Chunhua, X.; Wei, D.; Jianbing, M.; Ying, L.; Ming, L.

10.1101/2025.05.06.652550 — biophysics — Posted on 2025-05-10

4126 Mechanistic Insights into TYSM Protein Regulation by mTORC2 in Response to Chemotherapy.

Azzi, A.; El Sayed, A.; Serwa, R.; Zakrzewski, M.

10.1101/2025.05.06.652447 — biochemistry — Posted on 2025-05-10

4127 Nova: A library for rapid development of mass spectrometry software applications

Hoopmann, M. R.; McGann, C. D.; Rose, C. M.; Schweppe, D. K.

10.1101/2025.05.06.652494 — biochemistry — Posted on 2025-05-10

4128 RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation

Shimanski, B.; Marin, J. F.; Warminski, M.; McKeon, R. M.; Kowalska, J.; Jemielity, J.; Hadden-Perilla, J. A.; Mugridge, J. S.

10.1101/2025.05.09.653100 — biochemistry — Posted on 2025-05-10

4129 Effects of innate immune activation by Toll-like receptor agonists on ethanol consumption and preference in FVB/NJ x C57BL/6J hybrid mice.

Kisby, B. R.; Castro-Piedras, I.; Shanmugam, S.; Ponomarev, I.

10.1101/2025.05.06.652465 — animal behavior and cognition — Posted on 2025-05-10

4130 Human Messenger RNA Harbors Widespread Noncoding Splice Isoforms

Shi, Q.; Li, H.; Song, J.; Wu, H.; Zeng, Y.; Jiang, J.; Li, S.; Chen, Z.; He, X.

10.1101/2025.05.06.652571 — genomics — Posted on 2025-05-10

4131 Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses

Dien, V.; Thompson, C.; Rammel, T.; Roquero, J.; Krivit, M.; Yeo, G.; Honigfort, D.; Bhadha, P.; Brown-Greeves, C.; Dawood, M.; Elango, K.; Kwon, H. J.; Lopez, T.; Lo, A.; Manjunath, M.; Ren, P.; Song, B.; Sundkamp, M.; Tippana, R.; Van IJcken, W.; Wong, J.; Yao, J.; Zhou, D.; Arslan, S.; Kellinger, M.; Kia, A.; Kruglyak, S.; Previte, M.; He, M.

10.1101/2025.05.06.652479 — genomics — Posted on 2025-05-10

4132 ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

Simoes-Sousa, S.; Amin, N.; Lane, K. A.; Harrod, A.; Pedersen, M.; Pardo, M.; Rasetti-Escargueil, C.; Kozik, Z.; Begg, K. A. G.; Ribeiro, A.; Banerjee, S.; Stucki, M.; Harrington, K. J.; Chaudhary, J. S.; Downs, J. A.

10.1101/2025.05.10.653238 — molecular biology — Posted on 2025-05-10

4133 RNA decay regulates RNA abundances and transcriptome homeostasis using different mechanisms

Sorenson, R. S.; Sieburth, L. E.

10.1101/2025.05.09.653099 — molecular biology — Posted on 2025-05-10

4134 Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Kloet, M.; Chatrin, C.; Mukhopadhyay, R.; van Tol, B.; Smith, R.; Rotman, S.; Tjokrodirijo, R. T. N.; Zhu, K.; Gorelik, A.; van Veelen, P. A.; Ahel, D.; Ahel, I.; van der Heden van Noort, G. J.

10.1101/2025.05.08.652854 — molecular biology — Posted on 2025-05-10

4135 Host microbiome determines host specificity of the human whipworm, Trichuris trichiura

Stark, K. A.; Mkandawire, T. T.; Tolley, C.; Thompson, S.; Fortune-Grant, R.; Brandt, C.; Clare, S.; Lawley, T. D.; Cantacessi, C.; Almeida, A.; Grencis, R. K.; Nejsum, P.; Berriman, M.; Duque-Correa, M. A. A.

10.1101/2025.05.09.653168 — microbiology — Posted on 2025-05-10

4136 Environmental stress sensitivity determines bacterial Mn(II) oxidation

Bai, Y.; Lin, H.; Wang, Q.; Wang, Y.; Liang, J.; Ning, X.; Qu, J.

10.1101/2025.05.09.653071 — microbiology — Posted on 2025-05-10

4137 Expanding the known nucleorhabdovirus world: the final chapter in a trilogy exploring the hidden diversity of plant-associated rhabdoviruses

Debat, H. J.; Dietzgen, R. G.; Bejerman, N.

10.1101/2025.05.09.653113 — microbiology — Posted on 2025-05-10

4138 Reversion of a RND transporter pseudogene uncovers latent stress resistance in Brucella ovis

Kim, T.; Hong, B.; O'halloran, T.; Lisabeth, E.; Neubig, R.; Fiebig, A.; Crosson, S.

10.1101/2025.05.10.653276 — microbiology — Posted on 2025-05-10

4139 A Fundamental Relationship between TCR Diversity, Repertoire Size and Systemic Clonal Expansion: Insights from 30,000 TCRβ Repertoires

Zahid, H. J.; May, D. H.; Robins, H.; Greissl, J.

10.1101/2025.05.06.652462 — immunology — Posted on 2025-05-10

4140 Functional organization of the spinal locomotor network based on analysis of interneuronal activity

Musienko, P. E.; Gorskii, O. V.; Deliagina, T.; Zelenin, P.

10.1101/2025.05.06.652406 — neuroscience — Posted on 2025-05-10

4141 Neural Networks and Foundation Models: Two Strategies for EEG-to-fMRI Prediction

Donoso, M.

10.1101/2025.05.06.652346 — neuroscience — Posted on 2025-05-10

4142 Assessment of nucleic acid structure prediction in CASP16

Kretsch, R. C.; Hummer, A. M.; He, S.; Yuan, R.; Zhang, J.; Karagianes, T.; Cong, Q.; Kryshtafovych, A.; Das, R.

10.1101/2025.05.06.652459 — biophysics — Posted on 2025-05-10

4143 Alignment-free integration of single-nucleus ATAC-seq across species with sPYce

Zeitler, L.; Berthelot, C.

10.1101/2025.05.07.652648 — bioinformatics — Posted on 2025-05-10

4144 mtgRNA-db: An annotated database of multi-target CRISPR-Cas9 guide-RNAs in the human genome

Modrek, A. S.; Huynh, K.; Do, C.; Karp, J.; Deng, Y.; Zhang, Z.; Ezhilarasan, R.; Valor, B.; Cova, G.; Skok, J. A.; Sulman, E. P.

10.1101/2025.05.07.652656 — bioinformatics — Posted on 2025-05-10

4145 MetagenBERT: a Transformer Architecture using Foundational DNA Read Embedding Models to enhance Disease Classification

Roy, G.; Belda, E.; Prifti, E.; Chevaleyre, Y.; Zucker, J.-D.

10.1101/2025.05.06.652444 — bioinformatics — Posted on 2025-05-10

4146 TOP-SECRETS enables Cas9 nucleases to discriminate SNVs outside of PAMs

Herring-Nicholas, A.; Fisher-Huynh, S.; Josephs, E. A.

10.1101/2025.05.06.652491 — bioengineering — Posted on 2025-05-10

4147 A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

Ertekin, A.; Noronha, S. T.; Darko, C.; Massi, F.; Ryder, S. P.

10.1101/2025.05.09.653132 — biochemistry — Posted on 2025-05-10

4148 Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity

Barbieri, E. M.; Linsenmeier, M.; Whiteman, K. R.; Cheng, Y.; Braganza, S.; Copley, K. E.; Miranda-Castrodad, P.; Lewis, B.; Villafane, K.; Amado, D. A.; Davidson, B. L.; Shorter, J.

10.1101/2025.05.10.653282 — biochemistry — Posted on 2025-05-10

4149 Hydroxyl and Trifluoromethyl Radical Carbohydrate Footprinting for Probing Protein Binding Components of Oligosaccharides

Yusuph, Q.; Misra, S. K.; Liu, H.; Sharp, J. S.

10.1101/2025.05.06.652515 — biochemistry — Posted on 2025-05-10

4150 eLaRodON: identification of large genomic rearrangements in Oxford Nanopore sequencing data

Mikheeva, R.; Koryukov, M.; Leonov, P.; Mukhametdinova, V.; Borobova, V.; Laktionov, P.; Tarkhov, A.; Filipenko, M.; Kechin, A.

10.1101/2025.05.07.652628 — genomics — Posted on 2025-05-10

4151 Strengthening Global Trade Regulation Through Targeted Listings on CITES Appendix III

Watters, F.; Cassey, P.

10.1101/2025.05.06.652200 — ecology — Posted on 2025-05-10

4152 DSB repair kinetics impair CRISPR-Cas9 editing in human embryos

Egli, D.; Marin, D.; Treff, N.; Jerabek, S.; Sung, J.; Xu, J.; Talukdar, J.

10.1101/2025.05.07.652614 — developmental biology — Posted on 2025-05-10

4153 EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer

Lee, C.-H.; Kim, H.; Kim, D.-G.; Ha, S.; Jang, J.-Y.; Vitorino, F. N. d. L.; Gongora, J. M.; Kim, W.; Oh, Y.; Park, G.; Kang, H.; Im, S.-H.; Jung, C. K.; Kim, S.-Y.; Jung, I.; Won, J.-k.; Garcia, B. A.; Kim, S.; Lee, K. E.; Ryu, J.-K.

10.1101/2025.05.06.652476 — molecular biology — Posted on 2025-05-10

4154 Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts

Harrison, M.-C.; Rinker, D. C.; LaBella, A. L.; Opulente, D. A.; Wolters, J.; Zhou, X.; Shen, X.-X.; Groenewald, M.; Hittinger, C. T.; Rokas, A.

10.1101/2025.05.09.653161 — microbiology — Posted on 2025-05-10

4155 A Modular Genetic Toolbox for Precise Gene Regulation and Multi-Color Imaging in Streptococci

Mignolet, J.; Staub, J.; van der Meer, J. R.; Veening, J.-W.; Libante, V.

10.1101/2025.05.10.653270 — microbiology — Posted on 2025-05-10

4156 Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome

Corona-Cervantes, K.; Urrutia-Baca, V. H.; Gamez-Valdez, J. S.; Jimenez-Lopez, B.; Rodriguez-Gutierrez, N. A.; Chavez-Caraza, K.; Espiricueta-Candelaria, F.; Salas-Villalobos, U. A.; Ramos-Parra, P.; Gutierrez-Uribe, J. A.; Brunck, M.; Chuck-Hernandez, C.; Licona-Cassani, C.

10.1101/2025.05.09.653164 — microbiology — Posted on 2025-05-10

4157 Miniature bioreactor arrays for modeling functional and structural dysbiosis in inflammatory bowel disease

Newman, K. L.; Standke, A.; James, G.; Vendrov, K. C.; Inohara, N.; Bergin, I. L.; Higgins, P.; Rao, K.; Young, V. B.; Kamada, N.

10.1101/2025.05.09.653173 — microbiology — Posted on 2025-05-10

4158 Discovering Broader Host Ranges and an IS-bound Prophage Class Through Long-Read Metagenomics

Wirbel, J.; Hickey, A. S.; Chang, D.; Enright, N. J.; Dvorak, M.; Chanin, R. B.; Schmidtke, D. T.; Bhatt, A. S.

10.1101/2025.05.09.652943 — microbiology — Posted on 2025-05-10

4159 Genetic transformation of Gardnerella species and characterization of vaginolysin and sialidase mutants

Klimowicz, A. K.; Garcia, E. M.; Jefferson, K. K.; Dillard, J. P.

10.1101/2025.05.09.653190 — microbiology — Posted on 2025-05-10

4160 Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats

Bella, A.; Abdallah, K.; Rodrigues-Amorim, D.; Diego, A. M.; Decraene, C.; Hener, P.; Di Marino, C.; Finn, D. P.; Yalcin, I.; Roche, M.

10.1101/2025.05.06.652397 — neuroscience — Posted on 2025-05-10

4161 De Novo Protocell Membrane Formation Fueled by Primitive Metabolites

Khanal, S.; Fracassi, A.; Harjung, A.; Burkart, M.; Devaraj, N.

10.1101/2025.05.10.653202 — synthetic biology — Posted on 2025-05-10

4162 Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes

Zheng, L.; Yan, Y.; Zhou, B.; Lim, J.; Shi, D.; An, B.; Ko, B.; Klyder, E.; Pitchiaya, S.; Cai, D. J.; Boyden, E. S.; Wei, D.; Lio, P.; Linghu, C.

10.1101/2025.05.10.653182 — synthetic biology — Posted on 2025-05-10

4163 Phylogenetic dissection provides insights into the incongruity in the tree of Archaeplastida between the analyses of nucleus- and plastid-encoded proteins.

Isogai, R.; Harada, R.; Nakayama, T.; Inagaki, Y.

10.1101/2025.05.06.652364 — evolutionary biology — Posted on 2025-05-10

4164 Rhizaria are unexpectedly abundant and exhibit taxonomic and trophic diversity in the eastern subarctic Pacific

Blais, J. R.; Strom, S. L.

10.1101/2025.05.06.652060 — ecology — Posted on 2025-05-10

4165 Dietary Resilience of Termite Gut Microbiota and Enzymatic Function Reflects Feeding Strategy

Menezes, L. R. d.; Franco Cairo, J. P. L.; Costa-Leonardo, A. M.; Clerici, M. T. P. S.; Barreto, I. d. C.; dos Santos, B. S. F.; Arab, A.

10.1101/2025.05.07.651711 — ecology — Posted on 2025-05-10

4166 The effects of E. granulosus PSCs proteins on host immune cells were elucidated through Transcriptomic and Metabolomic analyses

Aimulajiang, K.; Chen, X.; Aizezi, M.; Zhou, T.; Lin, R.; Wen, H.

10.1101/2025.05.06.652359 — immunology — Posted on 2025-05-10

4167 MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies

Silva, M. C.; Lindmeier, H.; Pigini, P.; Laughlin, J.; Yu, Y.; Morrill, C.; Arnold, M. A.; Barraza, S. J.; Saadipour, K.; Dieterich, M.; Minnella, A.; Datta, K.; Zhang, N.; Narasimhan, J.; Trotta, C. R.; Woll, M. G.; Welch, E. M.; Benzow, K.; Karanjeet, K.; Lotz, S.; Bertucci, T.; Temple, S.; Haggarty, S. J.; Koob, M.; Trimmer, J.; Weetall, M.; Morini, E.

10.1101/2025.05.06.652428 — neuroscience — Posted on 2025-05-10

4168 Disruption of grin2A, an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish

Abramova, V.; Tomovic, E.; Kysilov, B.; Korinek, M.; Dobrovolski, M.; Hrcka Krausova, B.; Fili, K.; S. Abdel Rahman, F. E.; Bozikova, P.; Cerny, J.; Smejkalova, T.; Balik, A.; Vyklicky, L.

10.1101/2025.05.09.651809 — neuroscience — Posted on 2025-05-10

4169 De novo production of prenylnaringenin compounds by a metabolically engineered Escherichia coli

Gomes, D.; Rodrigues, J. L.; Scrutton, N. S.; Rodrigues, L. R.

10.1101/2025.05.09.653005 — synthetic biology — Posted on 2025-05-10

4170 g.nome, A Transparent Bioinformatics Pipeline that Enables Differential Expression and Alternative Splicing Analysis by Non-Computational Biologists

Corey, D. R.; Bryl, R.; Kang, X.; Wang, T. R.; Kunitomi, m.; Fuhrman, K.; Johnson, K.; Kearns, N.

10.1101/2025.05.09.652286 — bioinformatics — Posted on 2025-05-10

4171 Evolutionary consequences of bacterial resistance to a flagellotropic phage

Antani, J. D.; Theroux, A.; Emonet, T.; Turner, P. E.

10.1101/2025.05.06.652435 — evolutionary biology — Posted on 2025-05-10

4172 High-resolution comparative single-cell transcriptomics of doublesex-expressing neurons reveals evolutionary conservation and diversity of sexual circuits in Drosophila

Walsh, J. T.; Junker, I. P.; Chen, Y.-C. D.; Chen, Y.-C.; Gifford, H.; Ding, Y.

10.1101/2025.05.06.652433 — evolutionary biology — Posted on 2025-05-10

4173 Early-life paternal relationships predict adult female survival in wild baboons

Jansen, D. A. W. A. M.; Warutere, J. K.; Tung, J.; Alberts, S. C.; Archie, E.

10.1101/2025.01.22.634342 — evolutionary biology — Posted on 2025-05-10

4174 Potential yield and food provisioning gains from rebuilding the worlds coral reef fish stocks

Zamborain-Mason, J.; Cinner, J. E.; MacNeil, M. A.; Beger, M.; Booth, D.; Ferse, S. C. A.; Golden, C. D.; Graham, N. A.; Hoey, A. S.; Moulliot, D.; Connolly, S. R.

10.1101/2025.05.06.652379 — ecology — Posted on 2025-05-10

4175 Inhibitory effect of capsule on natural transformation of Streptococcus pneumoniae

Ma, S. X.; Eichner, H.; Cammer, M.; Weiser, J. N.

10.1101/2025.05.07.652784 — microbiology — Posted on 2025-05-10

4176 LAG3+ CD8+ T cell Subset Drives HR+/HER2- Breast Cancer Reduction in Bispecific Antibody Armed Activated T Cell Therapy

Barnes, R. W.; Thakur, A.; Onengut-Gumuscu, S.; Lum, L. G.; Dolatshahi, S.

10.1101/2025.01.04.631323 — immunology — Posted on 2025-05-10

4177 NOD2 modulates MDA5 signaling to promote coxsackievirus B3 replication

Kuss-Duerkop, S. K.; Atencio, L. C.; Nail, E. A.; Sparks, I. L.; Huynh, T. N.; Russo, B. C.; Keestra-Gounder, A. M.

10.1101/2025.05.06.652463 — immunology — Posted on 2025-05-10

4178 Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity derived biomarkers

Mehra, C.; Beyh, A.; Laiou, P.; Garces, P.; Jones, E.; Mason, L.; Buitelaar, J.; Johnson, M.; Murphy, D.; Loth, E.; Dell' Acqua, F.; Ewen, J.; Richardson, M.; O'Muircheartaigh, J.

10.1101/2025.01.04.631256 — neuroscience — Posted on 2025-05-10

4179 Performance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput

Sinn, L. R.; Wang, Z.; Alvarez, C.; Chelur, A.; Batruch, I.; Pribil, P.; Ludwig, D.; Tate, S.; Castro-Perez, J.; Messner, C.; Demichev, V.; Ralser, M.

10.1101/2025.05.06.652368 — systems biology — Posted on 2025-05-10

4180 Adaptation by stochastic tuning of gene expression in mammalian cells

Momen-Roknabadi, A.; Oikonomou, P.; Tavazoie, S.

10.1101/2025.05.07.651953 — systems biology — Posted on 2025-05-10

4181 A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

Mahadevan, R.; Garcia, E.; Sharma, R.; Qiu, H.; Elsheikh, A.; Parambi, R.; Abboud, C. S.; Pasteran, F.; Ramirez, M. S.; Kaye, K. S.; Bonomo, R. A.; Rao, G. G.

10.1101/2025.05.06.652358 — pharmacology and toxicology — Posted on 2025-05-10

4182 Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat

Meade, J.; Mesa, H.; Liu, L.; Zhang, Q.

10.1101/2025.05.09.648606 — pharmacology and toxicology — Posted on 2025-05-10

4183 Expanding the definition of MHC Class I peptide binding promiscuity to support vaccine discovery across cancers with CARMEN

Waleron, M. M.; Kallor, A. A.; Palkowski, A.; Daghir-Wojtkowiak, E.; Borole, P.; Kocikowski, M.; Polom, K.; Marino, F.; Monterde, B.; Mastromattei, M.; Venditti, D.; Stares, M.; The KATY Consortium, ; Singh, A.; Hupp, T.; Battail, C.; Laird, A.; Pesquita, C.; Zapata, L.; Symeonides, S. N.; Rajan, A.; Zanzotto, F. M.; Alfaro, J. A.

10.1101/2025.05.08.651510 — bioinformatics — Posted on 2025-05-10

4184 CLONEID: A Framework for Monitoring and Steering Subclonal Dynamics

Veith, T.; Beck, R. J.; Tagal, V.; Li, T.; Alahmari, S.; Cole, J.; Hannaby, D.; Yu, X.; Maksin, K.; Schultz, A.; Lee, H.; El Naqa, I.; Eschrich, S. A.; Lupo, J.; Ji, H.; Diaz, A.; Andor, N.

10.1101/2025.05.07.652202 — bioinformatics — Posted on 2025-05-10

4185 CORGIAS: identifying correlated gene pairs by considering evolutionary history in a large-scale prokaryotic genome dataset

Nishimura, Y.; Omae, K.; Tominaga, K.; Iwasaki, W.

10.1101/2025.05.07.652372 — bioinformatics — Posted on 2025-05-10

4186 Transfer learning framework via Bayesian group factor analysis incorporating feature-wise dependencies

Thirumalaisamy, D.; Black, N.; Gonen, M.; Nikolova, O.

10.1101/2025.05.07.648613 — bioinformatics — Posted on 2025-05-10

4187 In vivo tracking of CAR-T cells in tumors via nanobubble-based contrastenhanced ultrasound

Durig, D.; Franklin, J.; Perera, R.; Jackson, Z.; Vasanna, H.; Kolios, M.; Wald, D.; Exner, A. A.

10.1101/2025.05.06.651695 — bioengineering — Posted on 2025-05-10

4188 Uniaxial tensile tests and Digital Image Correlation analysis for the mechanical characterization of human Fascia Lata under different decellularization treatments

Demontis, F.; Loi, G.; Mazzotti, E.; Rodriguez Reinoso, M.; Vecchio, F.; Faini, A. C.; Leone, A.; Camusso, E.; Genzano Besso, F.; Surace, C.; Lacidogna, G.; Scaramozzino, D.

10.1101/2025.05.10.651796 — bioengineering — Posted on 2025-05-10

4189 Pre-Analytical Drivers of Bias in Bead-Enriched Plasma Proteomics

Korff, K.; Mueller-Reif, J. B.; Fichtl, D.; Albrecht, V.; Schebesta, A.-S.; Itang, E. C. M.; Virreiera Winter, S.; Holdt, L. M.; Teupser, D.; Mann, M.; Geyer, P. E.

10.1101/2025.05.07.652495 — biochemistry — Posted on 2025-05-10

4190 Molecular plasticity in the flavin binding pocket of BLUF domain evolves first light-gated endonuclease in bacterial system

Rahamtullah, ; Jitender, ; Kaushik, M. S.; Kumar, S.; Penzkofer, A.; Moglich, A.; Kateriya, S.

10.1101/2025.05.05.652191 — biochemistry — Posted on 2025-05-10

4191 Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling

Zhang, J.; Ubas, A. A.; de Borja, R.; Svensson, V.; Thomas, N.; Thakar, N.; Winters, A.; Khan, U.; Jones, M. G.; Thompson, J. D.; Tran, V.; Pangallo, J.; Papalexi, E.; Sapre, A.; Nguyen, H.; Sanderson, O.; Nigos, M.; Kaplan, O.; Schroeder, S.; Hariadi, B.; Marrujo, S.; Salvino, C. C. A.; Gallareta Olivares, G.; Koehler, R.; Geiss, G.; Rosenberg, A.; Roco, C.; Merico, D.; Alidoust, N.; Goodarzi, H.; Yu, J.

10.1101/2025.02.20.639398 — genomics — Posted on 2025-05-10

4192 Patterns and drivers of genome-wide codon usage bias in the fungal order Sordariales

Hensen, N.; Hiltunen Thoren, M.; Johannesson, H.

10.1101/2025.05.07.652452 — genomics — Posted on 2025-05-10

4193 Genomic alterations in persistently infecting oncolytic Newcastle disease virus reveal mechanisms of viral persistence in bladder cancer cells

Ahmad, U.; De Ming, C.; Choy, C. S.; Yusoff, K.; Veerakumarasivam, A.; Abdullah, S.

10.1101/2025.05.06.652422 — genomics — Posted on 2025-05-10

4194 Negative selection allows human primary fibroblasts to tolerate high somatic mutation loads induced by N-ethyl-N-nitrosourea

Cutler, R.; Heid, J.; Sun, S.; Lee, M.; Maslov, A. Y.; Zhang, L.; Sidoli, S.; Dong, X.; Vijg, J.

10.1101/2024.04.07.588286 — genetics — Posted on 2025-05-10

4195 Formation of chromosomal rearrangements in Saccharomyces cerevisiae diploids through regionally-biased non-allelic homologous recombination

Merriman, S. A.; Chapman, M. J.; Stewart, J. A.; Schmelzer, C. D.; Sharif, R. S.; Hemmerlein, M. J.; Puccia, C. M.; de Mattos, G. M.; Wienke, M. A.; Cornelio, D. A.; Dilsaver, M.; Watson, R. A.; Argueso, J. L.

10.1101/2025.05.08.650247 — genetics — Posted on 2025-05-10

4196 When less is not more: Limits to the evolution of metabolic dependence in spatially structured microbial communities

Ramesh, D.; Fara, E.; Oschmann, F.; Ugolini, G. S.; Stocker, R.; van Vliet, S.; Ackermann, M.; Schubert, O. T.

10.1101/2025.05.09.651753 — evolutionary biology — Posted on 2025-05-10

4197 The effectiveness of selection in a species affects the direction of amino acid frequency evolution

McShea, H.; Wheeler, A. L.; Goodman, P.; Weibel, C. A.; Wehbi, S.; James, J. E.; Huttley, G. A.; Masel, J.

10.1101/2023.02.01.526552 — evolutionary biology — Posted on 2025-05-10

4198 Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Pessina, P.; Nevo, M.; Shi, J.; Kodali, S.; Casas, E.; Cui, Y.; Richards, A. L.; Park, E. J.; Chen, X.; Levin-Ferreyra, F.; Stevenson, E.; Krogan, N. J.; Swaney, D. L.; Ying, Q.; Chen, Q.; Brumbaugh, J.; Di Stefano, B.

10.1101/2025.05.08.652299 — cell biology — Posted on 2025-05-10

4199 Characterization of hyperoxia-induced senescent lung macrophages in neonatal mice

Lin, F.; Lu, W.; Dennery, P. A.; Yao, H.

10.1101/2025.05.09.652066 — cell biology — Posted on 2025-05-10

4200 Specificity and mechanism of the double-stranded RNA-specific J2 monoclonal antibody

Bou-nader, C.; Juma, K. M.; Bothra, A.; Brasington, A. J.; Ghirlando, R.; Suzuki, M.; Garboczi, D. N.; Leppla, S. H.; Zhang, J.

10.1101/2025.05.09.649859 — molecular biology — Posted on 2025-05-10

4201 Early adjunct anti-PD-L1 immunotherapy improves outcomes and restores infection-induced immune paralysis in mice with invasive pulmonary mucormycosis

Wurster, S.; Pantaleon Garcia, J.; Wang, Y.; Albert, N. D.; Bharadwaj, U.; Matula, L.; Lewis, R. E.; Evans, S. E.; Kontoyiannis, D. P.

10.1101/2025.05.06.652431 — immunology — Posted on 2025-05-10

4202 Expectation modulates the hedonic experiences of and midbrain responses to sweet flavour

Mainetto, E.; Westwater, M. L.; Ziauddeen, H.; Diederen, K. M.; Fletcher, P. C.

10.1101/2025.05.09.651338 — neuroscience — Posted on 2025-05-10

4203 Trpv1-dependent Cacna1b gene inactivation reveals cell-specific functions of CaV2.2 channels in vivo

Meir, R. Y.; Sisti, M. S.; Andrade, A.; Lipscombe, D.

10.1101/2025.05.09.652131 — neuroscience — Posted on 2025-05-10

4204 Spatial Richness of Neural Magnetic Fields

Ali, Z.; Poon, A. S. Y.

10.1101/2025.05.08.652049 — neuroscience — Posted on 2025-05-10

4205 Region-specific Brain Targets Drive Circuit Formation and Maturation of Human Retinal Ganglion Cells

Huang, K.-C.; Jeng, H.-Y.; Abdulwahab, Q.; Cuevas, V.; Shihabeddin, E.; Young, C.; Hernandez, M.; Tran, N.; Samuel, M. A.; Meyer, J. S.

10.1101/2025.05.10.651091 — neuroscience — Posted on 2025-05-10

4206 NT5DC2 downregulation suppresses monoamine oxidase activity and increases catecholamine levels in PC12D cells

Yamaguchi, H.; Kawata, M.; Kodani, Y.; Saito, K.; Kameyama, T.; Nagasaki, H.; Nakashima, A.

10.1101/2025.05.07.651779 — neuroscience — Posted on 2025-05-10

4207 Unveiling the Developmental Dynamics and Functional Role of Odorant Receptor Co-receptor (Orco) in Aedes albopictus: A Novel Mechanism for Regulating Tuning Odorant Receptor Expression

Yao, H.; Qi, Q.; Gou, D.; Liang, S.; Ferguson, S. T.; Zhang, H.; Ye, Z.; LIU, F.

10.1101/2025.05.06.652105 — neuroscience — Posted on 2025-05-10

4208 Quantitative analysis of inhibitor-induced assembly disruption in human UDP-GlcNAc 2-epimerase using mass photometry

Boback, N.; Gorenflos Lopez, J. L.; Hackenberger, C. P.; Di Lella, S.; Lauster, D. C.

10.1101/2025.05.10.651030 — biophysics — Posted on 2025-05-10

4209 GENESIS: Generating scRNA-Seq data from Multiome Gene Expression

Riva, S. G.; Myers, B.; Buffa, F.; Tangherloni, A.

10.1101/2025.05.06.652399 — bioinformatics — Posted on 2025-05-10

4210 Tool Choice drastically Impacts CRISPR Spacer-Protospacer Detection

Neri, U.; Camargo, A. P.; Bushnell, B.; Roux, S.

10.1101/2025.05.06.652306 — bioinformatics — Posted on 2025-05-10

4211 Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis

Deepagan, V. G.; Ma, X.; Bazregari, F.; Pang, J.; Schaefer, J.; Hildebrand, J. M.; Dempsey, R. K.; Doerflinger, M.; Baldwin, C. A.; Schmidt, F. I.; Murphy, J. M.; Salvamoser, R.; Vince, J. E.

10.1101/2025.05.06.652432 — bioengineering — Posted on 2025-05-10

4212 Development of a digital analysis system for a novel 3D culture-based colony formation to detect malignantly transformed cells in human cell-based therapeutic products

Kusakawa, S.; Yang, T.; Sawada, R.; Sato, Y.; Yasuda, S.

10.1101/2025.05.08.651353 — bioengineering — Posted on 2025-05-10

4213 A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptide

Tejero-Ojeda, M. M.; Vives, A. B.; Wojciechowski, M.; Huy, P. D. Q.; Chwastyk, M.; Vallejo, M.; Novials, A.; Carrion-Vazquez, M.

10.1101/2025.05.06.652241 — biochemistry — Posted on 2025-05-10

4214 Ist2 promotes lipid transfer by Osh6 via its membrane tethering and lipid scramblase activities

Fabbre, A.; Syska, C.; Gobbi Sebinelli, H.; Cardinal, A.; Magdeleine, M.; Al-Qatabi, N.; D Ambrosio, J. M.; Montigny, C.; Lenoir, G.; Copic, A.; DRIN, G.

10.1101/2025.05.06.652365 — biochemistry — Posted on 2025-05-10

4215 Ultraconserved elements coupled with machine learning approaches resolve the systematics in model nematode species

Villegas, L. I.; Jimenez, L.; van der Sprong, J.; Holovachov, O.; Waldvogel, A.-M.; Schiffer, P. H.

10.1101/2025.05.06.652396 — evolutionary biology — Posted on 2025-05-10

4216 Specific Pathogen Free Ten Gene-Edited Pig Donor for Xenotransplantation

Xu, K.; Zhao, H.; Jia, B.; Wang, J.; Siddig, N. A. M. A.; Jamal, M. A.; Mao, A.; Liu, K.; Cheng, W.; Yang, C.; Wei, T.; Zhu, F.; Huo, X.; Jiao, D.; Guo, J.; Zhao, H.; Cheng, W.; Zhang, Y.; Zhang, X.; Jiang, L.; Zhang, Z.; Zhang, W.; Liang, T.; Zhao, H.-Y.; Sun, B.-C.; Wei, H.-J.

10.1101/2025.05.06.652168 — immunology — Posted on 2025-05-10

4217 Adaptation in somatosensory afferents improves rate and temporal coding of vibrotactile stimulus features

Halawa, A.; Dedek, C.; Medlock, L.; Al-Basha, D.; Ratte, S.; Prescott, S. A.

10.1101/2025.05.06.652367 — neuroscience — Posted on 2025-05-10

4218 Paroxetine-induced transient apoptosis and delayed neurogenesis act on social behavior in developing zebrafish

Sato, T.; Saito, K.; Oyu, T.; Tsuda, S.; Kurisaki, T.; Kajihara, T.; Nagashima, M.

10.1101/2023.11.10.566506 — pharmacology and toxicology — Posted on 2025-05-10

4219 iComBat: An Incremental Framework for Batch Effect Correction in DNA Methylation Array Data

Tomo, Y.; Nakaki, R.

10.1101/2025.05.06.652337 — bioinformatics — Posted on 2025-05-10

4220 An atlas of gene programs in non-small cell lung cancer delineates novel patterns of lineage vacillation, plasticity, and aggressiveness

Campbell, J. D.; Hong, R.; Klockner, P.; Mazzilli, S.; Spira, A. E.; Beane, J.; Yajima, M.

10.1101/2025.05.06.652317 — bioinformatics — Posted on 2025-05-10

4221 Concerted genome expansion of heritable symbionts in an insect host

Hornett, E. A.; Hayashi, M.; Nagamine, K.; Paterson, S.; Kageyama, D.; Hurst, G. D. D.

10.1101/2025.05.06.652349 — genomics — Posted on 2025-05-10

4222 Ancient introgression explains mitochondrial genome capture and mitonuclear discordance among South American collared Tropidurus lizards

Salles, M. M. A.; Carvalho, A. L. G.; Leache, A. D.; Martinez, N.; Bauer, F.; Motte, M.; Espinola, V.; Rodrigues, M. T.; Piantoni, C.; Pie, M. R.; Olivotto, A.; Colli, G. R.; Choueri, E. L.; Werneck, F. P.; Domingos, F. M. C. B.

10.1101/2025.04.25.650633 — genomics — Posted on 2025-05-10

4223 An essential role for the Hv1 voltage-gated proton channel in Pseudomonas aeruginosa corneal infection

Rodriguez, P.; Abbondante, S.; Marshall, M. M.; Abdelmeseh, J.; Tombola, F.; Pearlman, E.

10.1101/2024.07.15.603631 — microbiology — Posted on 2025-05-10

4224 Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life development

Lemmik, H.; Kim, E.; MacNicol, E.; Maselli, D.; Bernanos, M.; Li, Z.; Abdullahi, D.; Walters, E.; Serrano Navacerrada, M. E.; Zhou, W.; Ivetic, A.; Cash, D.; Westacott, L.

10.1101/2025.04.24.650541 — neuroscience — Posted on 2025-05-10

4225 Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complex

Stojaspal, M.; Brom, T.; Janovic, T.; Necasova, I.; Veverka, P.; Verma, N.; Uhrik, L.; Hernychova, L.; Hofr, C.

10.1101/2023.05.25.542057 — biochemistry — Posted on 2025-05-10

4226 Targeted Protein Degradation in Escherichia coli - depletion of the essential GroEL using CLIPPERs

Izert-Nowakowska, M. A.; Klimecka, M. M.; Antosiewicz, A.; Wroblewski, K.; Kowalski, J. J.; Bandyra, K. J.; Goral, T. K.; Kmiecik, S.; Serwa, R. A.; Gorna, M. W.

10.1101/2024.02.29.582761 — molecular biology — Posted on 2025-05-10

4227 Valence-dependent sensory-rhythmic stimulation entrains cortico-subcortical networks and enhances attention and memory

Hoyer, R. S.; Bernier, M.-F.; Martineau, L.; Lessard Bonaventure, P.; Labelle, C.; Borderie, A.; Blanchette, I.; Blumenthal, A.; Laureys, S.; Albouy, P.

10.1101/2025.01.03.631218 — neuroscience — Posted on 2025-05-10

4228 Mitfa-Independent Melanocyte Progenitors are Highly Susceptible to GNAQ-induced Uveal Melanoma in Adult Zebrafish

Yevdash, J. I.; Moore, R.; Li, Z.; Campbell-Hanson, K. R.; Robinson, D.; Gutelius, D.; Moore, S. P. G.; Friend, D.; O'Toole, I.; Cornell, R. A.; Lang, D.; Weigel, R. J.; Kenny, C.

10.1101/2025.05.05.652300 — cancer biology — Posted on 2025-05-10

4229 Sponges, ctenophores and the statistical significance of syntenies

Copley, R. R.

10.1101/2025.05.07.652388 — evolutionary biology — Posted on 2025-05-10

4230 Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia

Esfandi, H.; Javidan, M.; McGregor, E. R.; Anderson, R. M.; Pashaie, R.

10.1101/2025.05.06.652356 — neuroscience — Posted on 2025-05-10

4231 Large-scale Dynamical Fingerprints of Distributed Synaptic Alterations in Early-Stage Psychosis

Arazi, A.; Toso, A.; Grent-'t-Jong, T.; Uhlhaas, P. J.; Donner, T. H.

10.1101/2024.07.15.603513 — neuroscience — Posted on 2025-05-10

4232 Biocultural vulnerability of traditional crops in the Indian Trans Himalaya

Jaggi, H.; Anand, A.; Solari, K. A.; Echeverri, A.; Tobge, R.; Tsewang, T.; Suryawanshi, K.; Tuljapurkar, S. D.

10.1101/2024.10.22.619747 — plant biology — Posted on 2025-05-10

4233 A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity

Djajawi, T. M.; Huber, A.; Mendoza Rivera, S.; Srivaths, A.; Salehi, M.; Gunay, G.; Gerak, C.; Neil, L.; Ozaydin, O.; Voulgaris, O.; Al Halawani, A.; Gannon, D.; Khoshdoozmasouleh, N.; Jenkins, L. J.; Chan, K. F.; Behren, A.; Ernst, M.; Mielke, L. A.; Lelliott, E. J.; Dong, H.; Feltham, R.; Sutton, V. R.; Trapani, J. A.; Mariadason, J. M.; Pal, B.; Martin, S. J.; Vervoort, S. J.; Kearney, C. J.

10.1101/2025.05.09.652721 — cancer biology — Posted on 2025-05-10

4234 IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas

Arribas, A. J.; Guidetti, F.; Cannas, E.; Cascione, L.; Napoli, S.; Sartori, G.; Fuzio, F.; Pesenti, E.; Tarantelli, C.; Spriano, F.; Zucchetto, A.; Rossi, F. M.; Bruscaggin, A.; Rinaldi, A.; Castro de Moura, M.; Jovic, S.; Raimondi, A.; Pittau, R. B.; Terzi di Bergamo, L.; Ye, X.; Stathis, A.; Ben-David, Y.; Pan-Hammarstrom, Q.; Simonetta, F.; Stussi, G.; Zucca, E.; Gattei, V.; Brown, J. R.; Esteller, M.; Rossi, D.; Bertoni, F.

10.1101/2025.05.07.652612 — cancer biology — Posted on 2025-05-10

4235 A functional comparison of two transplantable syngeneic mouse models of melanoma: B16F0 and YUMM1.7

Klinke, D. J.; Gould, A.; Pirkey, A.; Razazan, A.; Deng, W.

10.1101/2025.05.09.652938 — cancer biology — Posted on 2025-05-10

4236 SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma.

Chakraborty, K.; Burman, R.; Satheesh, S.; Kieffer, M.; Karuhatty, C.; Yuan, Z.-F.; Tan, H.; Lkhagva, A.; High, A. A.; Wang, X.; Refaat, A.; Zhang, W.; Wang, Y.; Fan, Y.; Babu, M. M.; Shelat, A.; Stewart, E.; Dyer, M. A.; Bagga, P.

10.1101/2025.05.09.652501 — cancer biology — Posted on 2025-05-10

4237 A trans-acting enhancer lncRNA modulates androgen-dependent gene expression via sequence-specific interaction with the Androgen Receptor

Sultanov, R. I.; Suzdalenko, A.; Shnaider, P.; Zubkova, O.; Arapidi, G. P.

10.1101/2025.05.09.652846 — cancer biology — Posted on 2025-05-10

4238 Hematopoietic Stem Cells Modulate Tumor Immune-Environment to Target Triple-Negative Breast Cancer via Altering Mitochondrial Bioenergetics

Bose, B.; Mallick, S.; Biswas, S.; Shenoy, S. P.

10.1101/2025.05.07.652451 — cancer biology — Posted on 2025-05-10

4239 Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

Chang, S. M.; Bin Munim, M.; Trojan, S. E.; Shevzov-Zebrun, A.; Abbott, K. L.; Vander Heiden, M. G.

10.1101/2025.05.09.653205 — cancer biology — Posted on 2025-05-10

4240 p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancer

Rajan, P.; Zollo, R.; Guo, Y.; Alruwaili, M.; Zonneville, J.; Lieberman, M.; Morreale, B.; James, C.; Long, M.; Olejniczak, S.; Barbi, J.; Abrams, S.; Bakin, A. V.

10.1101/2025.05.08.652949 — cancer biology — Posted on 2025-05-10

4241 Complementary modes of resistance to EGFR TKI in lung adenocarcinoma through MAPK activation and cellular plasticity

Zatzman, M.; Quintanal-Villalonga, A.; Salehi, S.; Ceglia, N.; Lee, J. J.-K.; Pupo, A. N.; Falcon, C. J.; Rusk, N.; Masilionis, I.; Chaudhary, O.; Manoj, P.; Chaligne, R.; McPherson, A.; Rudin, C. M.; Shah, S. P.; Yu, H. A.

10.1101/2025.05.07.652714 — cancer biology — Posted on 2025-05-10

4242 EP300 and FCGR2B Emerge as Coordinated Mediators of Chromatin-Driven Immune Evasion in Melanoma Resistance

Shabana, B.; Salem, A.; Ramadan, N. A.; Khedr, A. M.

10.1101/2025.05.09.653199 — cancer biology — Posted on 2025-05-10

4243 FASN Inactivation-induced Progranulin (GRN) Expression Promotes Lysosome-dependent Cell Death to Suppress Leukemogenesis

Su, M.; Lv, Z.; Lu, Y.; Xie, X.; Zou, A.; Liu, H.; Ouyang, J.; Li, Q.; Ma, X.; Yang, Y.; Liu, K.; He, Y.; Xu, S.; Li, J.; Chen, L.; Lu, X.; Yang, J.; Liu, L.; Wu, C.; Zhang, L.; Sheng, Y.; Huang, Y.; Mei, Y.

10.1101/2025.05.06.652401 — cancer biology — Posted on 2025-05-10

4244 Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.

Shelton, M.; Anene, C. A.; Nsengimana, J.; Eldahshoury, M. K.; Keane, B.; Newton-Bishop, J. A.; Roberts, W.; Boyne, J. R.

10.1101/2025.05.09.651827 — cancer biology — Posted on 2025-05-10

4245 Mitochondrial Translation Inhibition Uncovers a Critical Metabolic-Epigenetic Interface in Renal Cell Carcinoma

Eckenstein, K.; Cengiz, B.; Chang, M.; Cartier, J. M.; Flory, M. R.; Thomas, G. V.

10.1101/2025.05.07.652786 — cancer biology — Posted on 2025-05-10

4246 Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis

Beernaert, B.; Jady-Clark, R. L.; Shah, P.; Ramon-Gil, E.; Lawson, N. M.; Brodtman, Z. D.; Tagore, S.; Stihler, F.; Carter, A. S.; Clarke, S.; Liu, T.; Zhu, W.; Erdal, E.; Easton, A.; Campo, L.; Browne, M.; Ash, S.; Waddell, N.; Crosby, T.; Lord, S. R.; Mann, D. A.; Melero, I.; de Andrea, C. E.; Tijhuis, A. E.; Foijer, F.; Hammond, E. M.; Akdemir, K. C.; Leslie, J.; Izar, B.; Parkes, E. E.

10.1101/2025.05.06.652454 — cancer biology — Posted on 2025-05-10

4247 Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation

Mestvedt, I. B.; Menu, E.; Misund, K.; Slordahl, T. S.; Rasheed, K.; Wolowczyk, C. I.; Hella, H.; Ryan, L.; Standal, T.; Espevik, T.; Yurchenko, M.

10.1101/2025.05.07.652607 — cancer biology — Posted on 2025-05-10

4248 Discovery and characterization of FX-909, a covalent inverse agonist of PPARG rationally designed to impose a powerful repressive bias in PPARG for the treatment of PPARG/RXRA-activated muscle-invasive urothelial cancers

Stuckey, J. I.; Mertz, J. A.; Wilson, J. E.; Williamson, K. E.; Li, Y.; Kuljanin, M.; DeLaBarre, B.; Chenail, G.; Nguyen, P. A.; Bailey, C. M.; Motley, W. M.; Audia, J. E.; Sims, R. J.

10.1101/2025.05.08.652848 — cancer biology — Posted on 2025-05-10

4249 Divergent Effects of Ultra-High Dose Arachidonic Acid versus Docosahexaenoic Acid on MYCN-Driven Neuroblastoma Progression in a Syngeneic Mouse Model

Powers, J. T.; Patel, V.; Li, Y. N.; Shen, X.; Brenna, T.

10.1101/2025.05.06.652504 — cancer biology — Posted on 2025-05-10

4250 The Establishment of Prostate-specific, SKP2 Humanized Mice by CRISPR Knock-in Method Reveals Neoplastic Initiation and Microenvironmental Reprogramming

Song, L.; Nguyen, V.; Xu, S.; Ho, K. V. T.; Hoang, B. H.; Yu, J.; Uchio, E.; Zi, X.

10.1101/2025.05.09.651611 — cancer biology — Posted on 2025-05-10

4251 Clonal effects of the Ras oncogene revealed by somatic mutagenesis in a Drosophila cancer model

Akiyama, T.; Gibson, M. C.

10.1101/2025.05.08.652841 — cancer biology — Posted on 2025-05-10

4252 GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases

Sriramareddy, S.; Siddarajappa, N.; Park, J. S.; Nguyen, T.; Kuznetsoff, J. N.; Kurtenbach, S.; Dollar, J. J.; Adams, D.; Licht, J.; Correa, Z.; Chen, A.; Harbour, J. W.; Smalley, K.

10.1101/2025.05.07.652654 — cancer biology — Posted on 2025-05-10

4253 Three-dimensional topological defects and quasi-long-range order in biological liquid crystals

Argento, A. E.; Varela, M. L.; Singh, G.; Visnuk, D. P.; Jacobovitz, B.; Rutherford, M. E.; Edwards, M. B.; Chaboche, Q.; Orringer, D. A.; Heth, J. A.; Castro, M. G.; Beller, D. A.; Blanch-Mercader, C.; Lowenstein, P.

10.1101/2025.04.14.648711 — biophysics — Posted on 2025-05-10

4254 Localized Reactivity on Protein as Riemannian Manifolds: A Geometric and Quantum-Informed Basis for Deterministic, Metal-Aware Reactive-Site Prediction

Park, H.

10.1101/2025.04.29.651260 — bioinformatics — Posted on 2025-05-10

4255 Modulation of cofilin 1 phosphorylation induces juvenile-like plasticity in the adult mouse visual cortex.

Dapueto, A.; Hayek, E.; Acunha, A.; Pannunzio, B.; Gomez, L.; Rossi, F. M.

10.1101/2025.05.05.652250 — neuroscience — Posted on 2025-05-10

4256 Cognitive Load Impairs Professional Scepticism in Decision-Making: The Mitigating Role of Default Nudges

Erfanian, M.; Meunier, L.; Gajewski, J.-F.

10.1101/2025.05.05.652071 — neuroscience — Posted on 2025-05-10

4257 MxlPy - Python Package for Mechanistic Learning in Life Science

van Aalst, M.; Nies, T.; Pfennig, T.; Matuszynska, A. B.

10.1101/2025.05.06.652335 — systems biology — Posted on 2025-05-10

4258 Expression of Arabidopsis Extracellular Vesicle Protein Markers in Nicotiana benthamiana Reveals Distinct Vesicle Subpopulations

Ghosh, S.; Innes, R. W.

10.1101/2025.05.06.652549 — plant biology — Posted on 2025-05-10

4259 Functional Genomic Screens Reveal RBBP4 as a Key Regulator of Cell Cycle Progression in TMZ-Resistant Glioblastoma

Kala, E. Y.; Senbabaoglu Aksu, F.; Ercan, E.; Ozbiyik, A.; Cingoz, A.; Yedier-Bayram, O.; Aksu, A. C.; Cavga, A. D.; Yilmaz, E.; Kok, I.; Dur Karasayar, A. H.; Kulac, I.; Syed, H.; Philpott, M.; Cribbs, A. P.; Bagci-Onder, T.

10.1101/2025.05.09.653010 — cancer biology — Posted on 2025-05-10

4260 The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer

Gupta, P.; Murad, R.; Ling, L.; Zhang, Y.; Duong-Polk, K.; Maganti, S.; Galapate, C.; Commisso, C.

10.1101/2025.05.08.652966 — cancer biology — Posted on 2025-05-10

4261 The STAMP inhibitor asciminib is a new treatment option for ABL-rearranged ALL revealing a novel role for the 5' fusion partner in determining drug response

Eadie, L. N.; McDougal, D. P.; Lagonik, E.; Schutz, C. E.; Conlin, T. S.; Page, E. C.; Rehn, J.; Bruning, J. B.; Moore, A. S.; Yeung, D. T.; Hughes, T. P.; White, D. L.

10.1101/2025.05.06.652078 — cancer biology — Posted on 2025-05-10

4262 EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism

HASHEMINASABGORJI, E.; Chen, H.-M.; Gatesman, T.; Younes, S. T.; Nobles, G.; Jaryani, F.; Mao, H.; Yu, K.; Deneen, B.; Yong, V. W.; Taylor, M.; Agnihotri, S.; Gallo, M.

10.1101/2025.05.08.652913 — cancer biology — Posted on 2025-05-10

4263 A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysis

Stevens, M.; Oltean, S.; Housden, B.

10.1101/2025.05.06.652376 — cancer biology — Posted on 2025-05-10

4264 High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular Subtypes

Kisakol, B.; Sturrock, A.; Cho, S.; Azimi, M.; Lindner, A.; Salvucci, M.; McDonough, E.; Fay, J.; O'Grady, T.; McCawley, N.; Burke, J. P.; McNamara, D.; Graf, J.; McDade, S.; Longley, D. B.; Ginty, F.; Prehn, J. H.

10.1101/2025.05.07.652478 — cancer biology — Posted on 2025-05-10

4265 Lymphocyte damage in four differently treated prostate radiotherapy cohort

Kocsis, Z. S.; Agoston, P.; Farkas, G.; Szekely, G.; Sandor, G. O.; Kliton, J.; Gesztesi, L.; Major, T.; Pesznyak, C.; Herein, A.; Stelczer, G.; Mihaly, D.; Frohlich, G.; Takacsi-Nagy, Z.; Polgar, C.; Juranyi, Z.

10.1101/2025.05.07.652586 — cancer biology — Posted on 2025-05-10

4266 Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Asada, S.; Zhu, G.; Abeykoon, J. P.; Tanaka, Y.; Nguyen, H.; Hirohashi, Y.; Iyer, D. R.; Ashton, N. W.; Mukkavalli, S.; Jiang, L.; Busso, M. D.; Thangaiah, J. J.; Robinson, S. I.; Parmar, K.; Van Allen, E.; Gillani, R.; Shapiro, G. I.; D'Andrea, A. D.

10.1101/2025.05.06.651696 — cancer biology — Posted on 2025-05-10

4267 Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

Sreekumar, A.; Blankemeyer, E.; Sterner, C. J.; Pan, T.-C.; Pant, D. K.; Acolatse, S.; Turkistani, H.; Belka, G. K.; Carlin, S. D.; Assenmacher, C.-A.; Sellmyer, M. A.; Mankoff, D. A.; Chodosh, L. A.

10.1101/2025.05.07.652632 — cancer biology — Posted on 2025-05-10

4268 Comparing Orientation-Dependent Transverse Relaxation at 3T and 7T: Deciphering Anisotropic Relaxation Mechanisms in White Matter

Pang, Y.; Raja, R.; Reddick, W. E.

10.1101/2025.05.05.652295 — biophysics — Posted on 2025-05-10

4269 SMALL MOLECULES WHICH CAN KEEP THE ECTODOMAINS OF HUMAN FcγRIIIa CLOSED: THERAPY FOR AUTOIMMUNE THROMBOCYTOPENIA PURPURA?

Ashish, F.

10.1101/2025.05.05.652134 — biophysics — Posted on 2025-05-10

4270 Guiding clustering and annotation in single-cell RNA sequencing using the average overlap metric

Thai, C.; Singh, A.; Herranz, D.; Khiabanian, H.

10.1101/2025.05.06.652497 — bioinformatics — Posted on 2025-05-10

4271 Personalized Gut-Liver Microphysiological System Maps Donor-Specific Tissue Resident Immunity and Reveals a Conserved Metabolic Crosstalk

Uslu, M.; Ran, R.; Siddiqui, M. F.; Liang, J.; Raechal, L.; Dogsa, M.; Perrot, C.; Lieberman, L. A.; Brubaker, D. K.; Trapecar, M.

10.1101/2025.05.05.652244 — bioengineering — Posted on 2025-05-10

4272 Impact of Tissue Sample Preparation Methods on Myelin-Sensitive Quantitative MR Imaging

Murguia, A.; Swanson, S. D.; Scheven, U.; Jacobson, A.; Nielsen, J.-F.; Fessler, J. A.; Seraji-Bozorgzad, N.

10.1101/2025.05.05.652075 — bioengineering — Posted on 2025-05-10

4273 The Missing Memory Imprint

Bowman, H.; Assant, A.; Aviles, A.

10.1101/2025.05.05.652252 — animal behavior and cognition — Posted on 2025-05-10

4274 Inconsistent relationships detected between seed size, shape, and persistence for different plant functional groups in the Pannonian flora

Törö-Szijgyarto, V.; Török, P.; Toth, K.; Malik-Roffa, H.; Suntaxi, L. R. G.; Madar, S.; Kovacsics-Vari, G.; McIntosh-Buday, A.; Cando, P. D.; Sonkoly, J.

10.1101/2025.05.05.652257 — ecology — Posted on 2025-05-10

4275 Separable global and local beta burst dynamics in motor cortex of primates

Khanna, P.; farrokhi, b.; Choi, H.; Griffin, S.; Heimbuch, I.; Novik, L.; Thiesen, K.; Morrison, J. H.; Morecraft, R.; Ganguly, K.

10.1101/2025.05.05.652217 — neuroscience — Posted on 2025-05-10

4276 Crossing effects in the tactile temporal order judgment task: A meta-analysis

Schmelter, N.; Langenberg, B.; Mayer, A.; Heed, T.

10.1101/2025.05.05.652194 — neuroscience — Posted on 2025-05-10

4277 An intracortical brain-computer interface for navigation in virtual reality in macaque monkeys

Saussus, O.; De Schrijver, S.; Garcia Ramirez, J.; Decramer, T.; Janssen, P.

10.1101/2025.05.05.652199 — neuroscience — Posted on 2025-05-10

4278 Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex

Huang, H.; Kay, K. N.; Gregg, N. M.; Valencia, G. O.; In, M.-H.; Kapeller, C.; Shu, Y.; Worrell, G. A.; Miller, K. J.; Hermes, D.

10.1101/2025.05.05.652264 — neuroscience — Posted on 2025-05-10

4279 Lrrns define a visual circuit underlying brightness and contrast perception

Putti, E.; Faini, G.; Dang, J. T.-M.; Eggeler, F.; Savaliya, J. H.; Duroure, K.; Vougny, J.; Bahl, A.; Lichtman, J. W.; Engert, F.; Boulanger-Weill, J.; Del Bene, F.; Albadri, S.

10.1101/2025.05.05.652281 — neuroscience — Posted on 2025-05-10

4280 S4, a Selective Androgen Receptor Modulator, Suppresses Breast Cancer Progression via Cell Cycle Arrest, Apoptosis, and Metabolic Alterations

Yavuz, M.; Demircan, T.

10.1101/2025.05.05.652263 — cancer biology — Posted on 2025-05-10

4281 DeSciDe: A tool for unbiased literature searching and gene list cu-ration unveils a new role for the acidic patch mutation H2A E92K

Douglas, C. J.; Seath, C. P.

10.1101/2025.05.05.652253 — bioinformatics — Posted on 2025-05-10

4282 A flexible framework for automated STED super-resolution microscopy

Hörl, D.

10.1101/2025.05.05.652196 — bioinformatics — Posted on 2025-05-10

4283 A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system

Taranenko, D.; Kotovskaya, O.; Kuznedelov, K.; Yanovskaya, D.; Demkina, A.; Fardeeva, S.; Mamontov, V.; Vierra, K.; Burman, N.; Li, D.; Wang, M.; Wiedenheft, B.; Severinov, K.; Semenova, E.; Isaev, A.

10.1101/2025.05.07.652737 — microbiology — Posted on 2025-05-10

4284 Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus

Genzoni, E.; Schwander, T.; Keller, L.

10.1101/2023.01.28.525977 — evolutionary biology — Posted on 2025-05-10

4285 Conserved inter-domain interactions drive trans-Golgi network localisation and trafficking of homologous copper-ATPases

Jose, S. M.; Maji, S.; Paul, M.; Mallick Gupta, A.; Gupta, A.

10.1101/2025.05.01.651363 — cell biology — Posted on 2025-05-10

4286 Understanding indirect assortative mating and its intergenerational consequences for educational attainment

Sunde, H. F.; Eilertsen, E. M.; Torvik, F. A.

10.1101/2024.06.21.600029 — genetics — Posted on 2025-05-10

4287 Not so scary after all? Decoding the landscape of fear through hormonal responses to risky times and places

Newediuk, L.; Jesmer, B. R.; Mastromonaco, G.; Vander Wal, E.

10.1101/2025.05.09.653052 — ecology — Posted on 2025-05-10

4288 Local nesting resources rather than floral food alter ground-nesting bee communities in grazed habitats

Collins, S. M.; Taylor, L. A.; Wright, K. W.; Lichtenberg, E. M.

10.1101/2024.08.19.608671 — ecology — Posted on 2025-05-10

4289 Brain-wide cell-type-specific noradrenergic modulation of the transcriptome

Slater, C.; Lantin, T.; Wellman, S.; Jia, L.; Gonzalez, G.; McFaline-Figueroa, J. L.; Wang, Q.

10.1101/2025.05.09.653136 — neuroscience — Posted on 2025-05-10

4290 RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR

Matthews, E. A.; Russ, J. B.; Qian, Y.; Zhao, S.; Thompson, P.; Methani, M.; Vestal, M. L.; Huang, Z. J.; Southwell, D. G.

10.1101/2024.12.03.626590 — neuroscience — Posted on 2025-05-10

4291 Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution

Ma, R.; Kang, M.; Kim, G. H.; Kang, H.; Lee, S.; Yang, Y.; Lee, H. J.; Choi, S.; Kim, S.; Kim, S.; Jun, Y.; Kim, H.; Zhang, Y.; Kim, U. S.; Kang, H. R.; Kim, Y.; Lee, Y.; Chung, W.; Kim, E.; Jeon, M.; Hwang, G.-S.; Choi, J.; Jung, Y.; Kim, J. Y.; Kim, E.; Lee, K. J.; Han, K.

10.1101/2025.05.06.652352 — neuroscience — Posted on 2025-05-10

4292 APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoids

Fang, H.; Liao, X.; Bullen, C. K.; Pu, R.; Wang, H.; Condoleo, J.; Cheat, S.; Chen, X.; Zhang, Y.; Zhang, S.; Huo, D.; Lissit, K.; Yang, A.; Jarvis, K.; Neifert, S.; Huang, Y.; Bishai, W.; Jain, S. K.; Dawson, T.; Dawson, V. L.; Xu, J.

10.1101/2025.05.08.652864 — neuroscience — Posted on 2025-05-10

4293 Linking Brain Entropy to Molecular and Cellular Architecture in Psychosis

Li, Q.; Liu, J.; Calhoun, V.

10.1101/2025.05.08.652921 — neuroscience — Posted on 2025-05-10

4294 A unified imaging-histology framework for superficial white matter architecture studies in the human brain

Hwang, Y.; Rodriguez-Cruces, R.; DeKraker, J.; Cabalo, D. G.; Leppert, I. R.; Thevakumaran, R.; Tardif, C. L.; Rudko, D. A.; Paquola, C.; Bazin, P.-L.; Bernasconi, A.; Bernasconi, N.; Concha, L.; Evans, A. C.; Bernhardt, B.

10.1101/2025.05.09.653169 — neuroscience — Posted on 2025-05-10

4295 Music as a real-time fMRI neurofeedback interface for modulating interhemispheric connectivity: effects on mood and recruitment of the putamen and insula

Sayal, A.; Pereira, J.; Direito, B.; Sousa, T.; Castelo-Branco, M.

10.1101/2025.05.06.652265 — neuroscience — Posted on 2025-05-10

4296 Reviving the Desired Gains Index: An optimal solution for parent selection in public plant breeding programs

Werner, C. R.; Gardner, K. A.; Tolhurst, D. J.

10.1101/2024.07.21.603926 — genetics — Posted on 2025-05-10

4297 Beyond urbanization metrics: Using graphical causal models to investigate mechanisms in urban ecology and evolution

Borden, J. B.; Gibbs, J.; Vanek, J. P.; Cosentino, B.

10.1101/2024.09.03.611045 — evolutionary biology — Posted on 2025-05-09

4298 The Evolutionary Landscape of tRNA Modifications in Archaea: Insights from High-Throughput Sequencing

Leavitt, J. S.; Moore, H.; Santangelo, T. J.; Lowe, T. M.

10.1101/2025.05.02.651894 — evolutionary biology — Posted on 2025-05-10

4299 Using deep learning to predict internalizing problems from brain structure in youth

Vandewouw, M. M.; Syed, B.; Barnett, N.; Arias, A.; Kelley, E.; Jones, J.; Ayub, M.; Iaboni, A.; Arnold, P. D.; Crosbie, J.; Schachar, R. J.; Taylor, M. J.; Lerch, J. P.; Anagnostou, E.; Kushki, A.

10.1101/2024.11.28.625869 — neuroscience — Posted on 2025-05-09

4300 Real-time affect decoding in the amygdalo-hippocampal circuit from dynamic auditory signals

Steiner, F.; Fruhholz, S.

10.1101/2025.05.09.652704 — neuroscience — Posted on 2025-05-09

4301 Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

Xu, W.; Keith, A. M.; Ye, W.; Hu, X.; Southall, N.; Juan, M. J.; Ferrer, M.; Henderson, M. J.; Sexton, P. M.; Deganutti, G.; Eiden, L. E.

10.1101/2025.04.16.649181 — pharmacology and toxicology — Posted on 2025-05-09

4302 Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load

MADAN, D. E.; Bansal, R.; Singhal, J.; Saini, M.; Shafi, S.; Joshi, N.; SINGH, S.

10.1101/2025.05.05.652326 — pathology — Posted on 2025-05-09

4303 Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth

Ma, Y.; Ayyadhury, S.; Singh, S.; Vashishath, Y.; Ozdemir, C.; McKee, T. D.; Nguyen, N.; Basi, A.; Mak, D.; Gomez, J.; Huse, J. T.; Noor, S.; Winkowski, D.; Baird, R.; Weinberg, J. S.; Lang, F. F.; Burks, J.; Bozdag, S.; Seeley, E. H.; Ene, C. I.

10.1101/2025.04.30.651361 — cancer biology — Posted on 2025-05-09

4304 Thermodynamic dissipation constrains metabolic versatility of unicellular growth

Cossetto, T.; Rodenfels, J.; Sartori, P.

10.1101/2024.03.21.585772 — biophysics — Posted on 2025-05-09

4305 Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells

Safa, B. T.; Rosenbohm, J.; Esfahani, A. M.; Minnick, G.; Moghaddam, A. O.; Lavrik, N. V.; Huang, C.; Charras, G.; Kabla, A.; Yang, R.

10.1101/2024.07.31.606021 — biophysics — Posted on 2025-05-09

4306 Identification of non-canonical peptides with moPepGen

Zhu, C.; Liu, L. Y.; Ha, A.; Yamaguchi, T. N.; Zhu, H.; Hugh-White, R.; Livingstone, J.; Patel, Y.; Kislinger, T.; Boutros, P. C.

10.1101/2024.03.28.587261 — bioinformatics — Posted on 2025-05-09

4307 ComBat-met: Adjusting Batch Effects in DNA Methylation Data

Wang, J.

10.1101/2024.08.13.607838 — bioinformatics — Posted on 2025-05-09

4308 A new alignment-free method: Subsequence Correlation Coefficient Vector(SCCFV) for influenza A comparison using virus genomes

He, L.; Yu, Z.; Wu, X.; Zhu, Y.; Han, S.; Yau, S. S.- T.

10.1101/2024.07.12.603253 — bioinformatics — Posted on 2025-05-09

4309 Improving Targeting Specificity of Transcranial Focused Ultrasound in Humans Using a Random Array Transducer: A k-Wave Simulation Study

Li, Z.; Yu, K.; Kosnoff, J.; He, B.

10.1101/2025.04.25.650630 — bioengineering — Posted on 2025-05-09

4310 Risk-taking incentives predict aggression heuristics in female gorillas

Smit, N.; Robbins, M. M.

10.1101/2025.05.09.653023 — animal behavior and cognition — Posted on 2025-05-09

4311 Hatcheries to high seas: climate change connections to salmon marine survival

Kitada, S.; Myers, K. W.; Kishino, H.

10.1101/2023.09.18.558187 — evolutionary biology — Posted on 2025-05-09

4312 Large language models possess some ecologicalknowledge, but how much?

Dorm, F.; Millard, J.; Purves, D.; Harfoot, M.; Mac Aodha, O.

10.1101/2025.02.10.637097 — ecology — Posted on 2025-05-09

4313 FAM210B regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis

Perfetto, M.; Ishfaq, M.; Mohideen, A.; Rondelli, C. M.; Gillis, S.; Tejero, J.; Stratman, A. N.; Riggins, R. B.; Yien, Y. Y.

10.1101/2023.09.26.559581 — developmental biology — Posted on 2025-05-09

4314 Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance

Cole, C. G.; Zhang, Z. J.; Dommaraju, S. R.; Dong, Q.; Pope, R. L.; Son, S. S.; McSpadden, E. J.; Woodson, C. K.; Lin, H.; Dylla, N. P.; Sidebottom, A. M.; Sundararajan, A.; Mitchell, D. A.; Pamer, E. G.

10.1101/2025.05.06.652565 — microbiology — Posted on 2025-05-09

4315 Mesolimbic dopamine ramps reflect environmental timescales

Floeder, J. R.; Jeong, H.; Mohebi, A.; K Namboodiri, V. M.

10.1101/2024.03.27.587103 — neuroscience — Posted on 2025-05-09

4316 Acute Administration of Oxytocin in the Functional Recovery of Neurocognitive and Social Deficits Following Juvenile Frontal Traumatic Brain Injury

Shonka, S.; Ford, C.; Hylin, M. J.

10.1101/2025.04.30.651517 — neuroscience — Posted on 2025-05-09

4317 Neuromodulation of risk preferences encoded in human orbitofrontal cortex activity

Skular, A.; Jin, L.; Overton, J.; Saez, I.

10.1101/2025.05.06.650317 — neuroscience — Posted on 2025-05-09

4318 Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells

Thompson, J. C.; Park, A.; Kouakou, Y. I.; Miller, Z. A.; Darwich, N. F.; Adappa, N. D.; Palmer, J. N.; Lee, R. J.

10.1101/2024.11.08.622701 — physiology — Posted on 2025-05-09

4319 Prioritization of Deleterious Mutations Improves Genomic Prediction and Increases the Rate of Genetic Gain in Common Bean (Phaseolus vulgaris L.), a Simulation Study

Cordoba Novoa, H. A.; Hoyos-Villegas, V.

10.1101/2025.05.05.652208 — genetics — Posted on 2025-05-09

4320 Introducing Large Language Models to Human-Based Etymological Classification in Zooplankton

haruto, s.; keito, i.; kota, n.; takumi, t.

10.1101/2025.05.08.652882 — microbiology — Posted on 2025-05-09

4321 circEPSTI1 Enables Dengue Innate Immune Evasion by Sponging miR-942-5p, a Repressor of AKT1 and the Viral Genome

Das, N.; Krishnamoorthy, P.; Junghare, K. R.; Raj, A. S.; Saha, P.; Pal, K.; Adhya, S.; Garg, A.; Khetan, D.; Kumar, A.; Kumar, H.

10.1101/2025.05.05.652247 — immunology — Posted on 2025-05-09

4322 Early downregulation of HC-specific genes in the vestibular sensory epithelium during chronic ototoxicity

Borrajo, M.; Greguske, E. A.; Maroto, A. F.; Palou, A.; Gimenez-Esbri, V.; Sedano, D.; Gut, M.; Esteve-Codina, A.; Martin-Mur, B.; Barrallo-Gimeno, A.; Llorens, J.

10.1101/2025.05.05.652224 — neuroscience — Posted on 2025-05-09

4323 A compact multisensory representation of self-motion is sufficient for computing an external world variable

May, C. E.; Cellini, B.; van Breugel, F.; Nagel, K. I.

10.1101/2025.05.09.653128 — neuroscience — Posted on 2025-05-09

4324 MITF-Independent Melanocyte Progenitors are Highly Susceptible to GNAQ-induced Uveal Melanoma in Adult Zebrafish

Yevdash, J. I.; Moore, R.; Li, Z.; Campbell-Hanson, K. R.; Robinson, D.; Gutelius, D.; Moore, S. P. G.; Friend, D.; O'Toole, I.; Cornell, R. A.; Lang, D.; Weigel, R. J.; Kenny, C.

10.1101/2025.05.05.652300 — cancer biology — Posted on 2025-05-09

4325 RNA Mango-based Sensors for Lead

Biswas, A.; DasGupta, S.

10.1101/2025.05.07.652743 — biochemistry — Posted on 2025-05-09

4326 Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex

Giladi, M.; Kredi, S.; Guardiani, C.; Aviram, L.; Vankova, P.; Man, P.; Giacomello, A.; Haitin, Y.

10.1101/2025.05.09.652838 — biochemistry — Posted on 2025-05-09

4327 Isoswitching drives the aging process in human brains

Erdogdu, B.; Ji, H. J.; Rudnick, Z. C.; Pertea, M.; Salzberg, S.

10.1101/2025.05.05.652255 — genomics — Posted on 2025-05-09

4328 Monitoring mammals, birds and fish during summer 2022 at the outlet of an agricultural stream by mtDNA

Villemur, R.

10.1101/2025.05.05.652203 — ecology — Posted on 2025-05-09

4329 Heart spheroids from primary cells for studying cardiac development

Li, G.; Chang, C.; Xu, J.; Chang, S.

10.1101/2025.05.05.652113 — developmental biology — Posted on 2025-05-09

4330 Single camera estimation of microswimmer depth with a convolutional network

Hosseini, A.; Fosse, C.; Awada, M.; Stimberg, M.; Brette, R.

10.1101/2025.05.09.653055 — microbiology — Posted on 2025-05-09

4331 Endophilin mediated endocytosis and Epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells

Sharma, P.; Tanwar, M.; Choudhary, E.; Sundaram, N. M.; Ojha, D.; Mishra, L.; Nain, M.; Rode, A.; Prasad, V. M.; Vrati, S.; Kalia, M.

10.1101/2025.05.08.652984 — microbiology — Posted on 2025-05-09

4332 Genome-wide binding of the cyclic AMP receptor protein in enteroaggregative Escherichia coli suggests a role in modulating virulence

Alhammadi, M. M.; Hothersall, J.; Lloyd, G. S.; Titman, S. V.; Guest, T.; Browning, D. F.; Grainger, D. C.; Busby, S. J. W.; Haycocks, J. R. J.

10.1101/2025.05.09.652842 — microbiology — Posted on 2025-05-09

4333 Novel action of proline-rich antimicrobial peptides Api88, Api137, Onc72 and Onc112 against Pseudomonas aeruginosa and Escherichia coli in ion-rich environments.

Pantarat, N.; Knappe, D.; Reynolds, E. C.; Hoffmann, R.; O'Brien-Simpson, N. M.

10.1101/2025.05.09.653031 — microbiology — Posted on 2025-05-09

4334 Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1

Banas, V.; Seehra, K.; Mahoney, M.; Kyriukha, Y.; Alisio, C.; Fath, M.; Han, Z.; Bricker, T. L.; Tartell, M.; Whelan, S. P. J.; Boon, A.; Janetka, J. W.

10.1101/2025.05.09.652710 — microbiology — Posted on 2025-05-09

4335 Metabolic reprogramming of protists within the microbiome of sinking particles

Yang, Q.; Endo, H.; Yang, Y.; Ebihara, A.; Yamada, Y.; Fukuda, H.; Nagata, T.; Ogata, H.

10.1101/2025.05.08.652973 — microbiology — Posted on 2025-05-09

4336 Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling

Cho, S. H.; Brookens, S. K.; Raybuck, A. L.; Meyer, K.; Paik, Y. C.; Hamilton, J. A.; Li, J.; Kalecky, K.; Park, C.; Hicks, S. L.; Karijolich, J.; Bottiglieri, T.; Rathmell, J.; Mogilenko, D.; Scharer, C. D.; Boothby, M. R.

10.1101/2025.05.05.652119 — immunology — Posted on 2025-05-09

4337 NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion

Niou, Z.-X.; Yang, S.; Enriquez, A.; Sri, A.; Hines, C.; Tennessen, J. M.; Wu, C.-S.; Huang, J.-Y.; Lu, H.-C.

10.1101/2025.05.05.652246 — neuroscience — Posted on 2025-05-09

4338 Cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis include innate and adaptive immune processes

Bridges, K.; Awany, D.; Gela, A.; Mwanbene, T.-D.; Sassetti, C. M.; Scriba, T. J.; Lauffenburger, D. A.

10.1101/2025.05.05.652268 — systems biology — Posted on 2025-05-09

4339 Success factors for inter- and transdisciplinary research. Lessons from a decade of studies on invasive aquatic species.

Adrian-Kalchhauser, I.; Bussmann-Charran, K.; N'Guyen, A.; Hirsch, P. E.; Wiegleb, j.; Bergmann, L.; Burkhardt-Holm, P.

10.1101/2025.05.05.652198 — scientific communication and education — Posted on 2025-05-09

4340 CRIS: A Centralized Resource for High-Quality RNA Structure and Interaction Data in the AI Era

Lee, W. H.; Li, K.; Bai, J.; Zhang, M.; Sharma, A.; Lu, Z.

10.1101/2025.05.05.652292 — bioinformatics — Posted on 2025-05-09

4341 Intracellular Delivery of Bone Nanoparticles to Mitigate Irradiation-Induced Damage in Bone Marrow Mesenchymal Stem Cells

Wang, B.; Ma, X.; Nguyen, C.; Stellpflug, A.; Li, S.; Han, L.; Frei, A.; Himburg, H.; Gu, L.; Dong, P.; Wang, S.; Mak, M.; Wu, R.

10.1101/2025.05.05.652269 — bioengineering — Posted on 2025-05-09

4342 A-eye: Automated 3D Segmentation of Healthy Human Eyeand Orbit Structures and Axial Length Extraction

Barranco, J.; Luyken, A. K.; Stachs, O.; Langner, S.; Franceschiello, B.; Bach Cuadra, M.

10.1101/2025.05.05.652187 — bioengineering — Posted on 2025-05-09

4343 Real time monitoring of hydrogenotrophic methanogenesis under deep saline aquifers conditions

Vidal, E.; Cario, A.; Jouvin, M.; Abadie, M.; Nguyen, O.; Erriguible, A.; Ranchou-Peyruse, A.; MARRE, s.

10.1101/2025.05.05.652176 — bioengineering — Posted on 2025-05-09

4344 Computational Assessment of Circularization Impact on Saxitoxin G-quadruplex Aptamer Performance

Gao, S.; Deng, B.; Cheng, D.; Zhou, R.; Wu, Y.; Jia, Y.; Xiao, B.; Yu, H.; Ma, Z.; Gao, Y.; Li, T.; Liu, G.; Zhang, Y.; Cheng, J.; Zhu, H.; Chen, H.; Wang, L.; Sun, M.

10.1101/2025.05.05.652042 — biochemistry — Posted on 2025-05-09

4345 Traits of Bathy Phytochromes and Application to Bacterial Optogenetics

Bohm, C.; Lehtinen, K.; Multamaki, E.; Vanhatalo, R.; Brander, O.; Meier, S. S. M.; Rumfeldt, J.; Moglich, A.; Takala, H.

10.1101/2025.05.05.652137 — biochemistry — Posted on 2025-05-09

4346 APPLE-MS: A affinity purification-mass spectrometry method assisted by PafA-mediated proximity labeling

Luo, S.; Xie, L.; Yang, L.; Hu, Z.; Wang, L.; Wang, Y.; Li, Q.; Guo, S.; Tao, S.-c.; Jiang, H.

10.1101/2025.05.06.652320 — biochemistry — Posted on 2025-05-09

4347 Maternal time budgets of feral goats at high latitudes in northwest Europe.

Dunbar, R. I. M.; Anderson, R.; Knight, M.

10.1101/2025.05.05.652180 — animal behavior and cognition — Posted on 2025-05-09

4348 Nicking Loop™: An infinite amplification of single-stranded circular DNA

Adamusova, S.; Laine, N.; Korkiakoski, A.; Hirvonen, T.; Musku, A.; Rantasalo, T.; Kim, J.; Blomster, J.; Laine, J.; Tamminen, M.; Pursiheimo, J.-P.

10.1101/2025.05.08.652165 — molecular biology — Posted on 2025-05-09

4349 CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred

Sünderhauf, D.; Ringger, J. R.; Payne, L. J.; Pinilla-Redondo, R.; Gaze, W. H.; Brown, S. P.; van Houte, S.

10.1101/2025.05.09.653016 — microbiology — Posted on 2025-05-09

4350 Profiling Bile Acids in the Stools of Humans and Animal Models of Cystic Fibrosis

Carmichael, M.; Valls, R.; Soucy, S.; Sanville, J.; Madan, J.; Surve, S.; Sundrud, M. S.; O'Toole, G.

10.1101/2025.05.08.651222 — microbiology — Posted on 2025-05-09

4351 Discovery of a Novel Coltivirus in a Newly Identified Bat Bug Species (Heteroptera: Cimicidae) in Cambodia

Siegers, J. Y.; Auerswald, H.; Maquart, P.-O.; Szentivanyi, T.; Guillebaud, J.; Hoem, T.; Suor, K.; Pum, L.; Khun, L.; Nuon, S.; Chea, K.; Heang, V.; Bienes, K. M.; Nouhin, J.; Boyer, S.; Karlsson, E. A.

10.1101/2025.05.09.652812 — microbiology — Posted on 2025-05-09

4352 Development of Surface Enhanced Raman Spectra coupled with Machine Learning Analysis for Differentiation of Closely Related Species within Enterobacter cloacae Complex

Zhou, M.; Xiong, S. X.; Li, Y.; Xu, Y.-C.; Gu, B.

10.1101/2025.05.08.652998 — microbiology — Posted on 2025-05-09

4353 Incorporation of macrophage immune stresses into an assay for drug tolerance in intracellular Mycobacterium tuberculosis

Kirubakar, G.; Johnston, L.; Lee, B. N. R.; Russell, D. G.; Simwela, N. V.

10.1101/2025.05.09.653069 — microbiology — Posted on 2025-05-09

4354 Competition between plasmids conferring the same antimicrobial resistance leads to plasmid-host network specialisation

Newbury, A.; Buckling, A.; Hesse, E.; Sanders, D.

10.1101/2025.05.09.652947 — microbiology — Posted on 2025-05-09

4355 Deltaviruses spread through a viral Trojan Horse

McKellar, J.; Fouillen, A.; Lyonnais, S.; Seigneuret, F.; Blanchard, M.-P.; Trullo, A.; Kumarasinghe, L.; De Rossi, S.; Sleiman, R.; Desagher, S.; Gaudin, R.; de Rocquigny, H.; Granier, S.; Hepojoki, J.; Majzoub, K.

10.1101/2025.05.09.653040 — microbiology — Posted on 2025-05-09

4356 A tripartite protein complex promotes DNA transport during natural transformation in firmicutes.

Dewailly, M.; Fauconnet, Y.; Ducrot, C.; Soulet, A.-L.; Campo, N.; Guerois, R.; Radicella, J. P.; Polard, P.; Andreani, J.; JOHNSTON, C. H. G.

10.1101/2025.05.09.652193 — microbiology — Posted on 2025-05-09

4357 A nasal vaccine candidate, based on S2 and N proteins from SARS-CoV-2, generates a broad antibody response systemic and at lower respiratory tract.

Lobaina, Y.; Chen, R.; Vazquez-Blomquist, D.; Suzarte, E.; Zhang, M.; Zhou, Z.; Lan, Y.; Guillen, G.; Li, W.; Perera, Y.; Hermida, L.

10.1101/2025.05.09.653001 — immunology — Posted on 2025-05-09

4358 A Spinal Circuit for Hypoxia-Evoked Motor Output in Zebrafish Larvae

Foianini, S.; Herrera, K. J.; Engert, F.

10.1101/2025.05.07.652688 — neuroscience — Posted on 2025-05-09

4359 Neural and Computational Mechanisms Underlying One-shot Perceptual Learning in Humans

Hachisuka, A.; Shor, J. D.; Liu, X. C.; Friedman, D.; Dugan, P.; Saez, I.; Panov, F. E.; Wang, Y.; Doyle, W.; Devinsky, O.; Oermann, E. K.; He, B. J.

10.1101/2025.05.09.635727 — neuroscience — Posted on 2025-05-09

4360 Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays

Sheth, U.; Harrison, R.; Ferber, K.; Rosenbaugh, E. G.; Bevis, A.; Khillan, R.; Benatar, M.; Bjorklund, N. L.; Di Daniel, E.; Harris, G. A.; Kahn, O. I.; Liu, Y.; Zetterberg, H.; Mitic, L. L.; Graham, D.; Gendron, T. F.

10.1101/2025.05.05.652212 — neuroscience — Posted on 2025-05-09

4361 Intrinsic and TDP-43 dysfunction-induced catabolic stress elicit neuroprotective cellular degradation in ALS-vulnerable motor neurons

Asakawa, K.; Tomita, T.; Shioya, S.; Handa, H.; Saeki, Y.; Kawakami, K.

10.1101/2025.05.06.652552 — neuroscience — Posted on 2025-05-09

4362 Mesenchymal-epithelial transition serves to rapidly, yet transiently, restore the endometrial epithelium during postpartum murine uterine regeneration

Wang, Z.; Davenport, K.; Behura, S.; Patterson, A.

10.1101/2025.05.05.652287 — physiology — Posted on 2025-05-09

4363 A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models

Gao, J.; Bamidele, N.; Pires-Ferreira, D.; Destefano, A.; Tang, Q.; Cao, Y.; Xie, J.; Gao, G.; Gruntman, A.; Sontheimer, E.; Flotte, T.; Xue, W. J.

10.1101/2025.05.07.652636 — bioengineering — Posted on 2025-05-09

4364 A Platform for Mitochondrial Profiling in Enriched Kidney Segments Under Thermodynamic Control

Decker, S. T.; Opurum, P. C.; Choi, R. H.; Paula, V. L.; Kurian, A. S.; Stewart, D.; Nikolova, L. S.; Sanchez, A.; Al-Rabadi, L.; Ramkumar, N.; Fisher-Wellman, K. H.; Funai, K.

10.1101/2025.05.05.652276 — biochemistry — Posted on 2025-05-09

4365 A Super-Loop Extrusion Mechanism Shapes the 3D Mitotic Chromosome Folding

Norouzi, D.

10.1101/2025.05.05.652288 — genomics — Posted on 2025-05-09

4366 Th9-endothelial cell crosstalk promotes inflammatory atherosclerotic cardiovascular disease

Baral, I.; Baumer, Y.; Burma, A.; Sylvester, M.; Jones, K.; Kitakule, M. M.; Dey, A.; Rodante, J.; Gutierrez-Huerta, C. A.; Taramangalam, B.; Perez, J. D.; Guo, L.; Grogan, A.; Shiraki, T.; Finn, A.; Son, A.; Cho, K.; Khillian, J.; Chen, M.; Mehta, N. N.; Frischmeyer-Guerrerio, P. A.; Milner, J. D.; Powell-Wiley, T. M.; Falduto, G. H.; Schwartz, D. M.

10.1101/2025.05.05.652112 — immunology — Posted on 2025-05-09

4367 γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis

Meca-Laguna, G.; Admasu, T. D.; Shankar, A.; Barkovskaya, A.; Collibee, I.; Krakauer, A.; Tran, T.; Rae, M.; Sharma, A.

10.1101/2025.05.05.652251 — immunology — Posted on 2025-05-09

4368 Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine

Woodburn, S. C.; Kuhn, A.; Dadosky, D. T.; Mueller, E.; Bollinger, J. L.; Gonzalez, R. M. S.; Robinson, J. E.; Vollmer, L. L.; Wohleb, E. S.

10.1101/2025.05.05.652266 — neuroscience — Posted on 2025-05-09

4369 The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

Callahan, A.; Mojumdar, A.; Hu, M.; Wang, A.; Griffith, A.; Huang, N.; Chua, X. Y.; Mroz, N. M.; Puterbaugh, R. Z.; Reilly, S. P.; Salomon, A. R.

10.1101/2025.05.05.652301 — systems biology — Posted on 2025-05-09

4370 Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms

AlSiraj, Y.; Putnam, K.; English, V.; Ensor, C. M.; Cassis, L. A.

10.1101/2025.05.05.652275 — pharmacology and toxicology — Posted on 2025-05-09

4371 Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells

Qabar, C. M.; Waldburger, L.; Keasling, J. D.; Portnoy, D. A. M.; Cox, J. S.

10.1101/2025.05.05.651767 — bioengineering — Posted on 2025-05-09

4372 Lineage-Specific Evolution, Structural Diversity, and Activity of R2 Retrotransposons in Animals

Hassan, N. T.; Van Treeck, B.; Rodriguez-Vargas, A.; Sheppard, A. E.; Adelson, D. L.; Collins, K.

10.1101/2025.05.05.652312 — evolutionary biology — Posted on 2025-05-09

4373 Hydrogen sulfide protects erectile function through stimulation of antioxidant defense in the corpus cavernosum

Azeez, T. A.; Rhein, P. R.; Pierre, C. J.; Ihrig, C. M.; La Favor, J. D.

10.1101/2025.05.05.652305 — physiology — Posted on 2025-05-09

4374 Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load

singh, s.; MADAN, D. E.; Bansal, R.; Singhal, J.; Saini, M.; Shafi, S.; Joshi, N.

10.1101/2025.05.05.652326 — pathology — Posted on 2025-05-09

4375 CellTune: An integrative software for accurate cell classification in spatial proteomics

Bussi, Y.; Shainshein, D.; Ovits, E.; Posner, S.; Azulay, N.; Maimon, N.; Keidar Haran, T.; Ben-uri, R.; Brown, C.; Schuldiner, N.; Yaniv, E.; Van Valen, D. A.; Milo, I.; Elhanani, O.; Schiemann, R.; Keren, L.

10.1101/2025.05.05.652215 — bioinformatics — Posted on 2025-05-09

4376 Evolutionary implications of plant host interactions with a generalist pathogen

Maerkle, H.; Bergelson, J.

10.1101/2025.05.05.652313 — evolutionary biology — Posted on 2025-05-09

4377 Relating Monosynaptic and Functional Connectivity - Complementary Perspectives on Neural Computation -

Shinomoto, S.; Tsubo, Y.

10.1101/2025.05.05.652327 — neuroscience — Posted on 2025-05-09

4378 Regulation of the branched-chain amino acid pathway and its crosstalk to carbon metabolism in yeast

Escalera-Fanjul, X.; Bolaji, O.; Drotleff, B.; DeLuna, A.; Alexandrov, T.; Klipp, E.

10.1101/2025.05.05.652184 — systems biology — Posted on 2025-05-09

4379 HIF1α and HIF2α mRNA Expression in Oral Squamous Cell Carcinoma does not correlate with protein expression

Pandey, M.; Singh, P.; Nath, G.; Kumar, D.; Kar, A. G.

10.1101/2025.05.02.651922 — cancer biology — Posted on 2025-05-09

4380 A polyomavirus-positive Merkel cell carcinoma mouse model supports a unified cancer origin

yang, w.; contente, s.; rahman, s.

10.1101/2025.05.06.652325 — cancer biology — Posted on 2025-05-09

4381 An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in M. tuberculosis using a reproduciblealgorithmic approach.

Adlard, D.; Joseph, L.; Webster, H.; O'Reilly, A.; Knaggs, J.; Peto, T. E.; Crook, D. W.; Omar, S. V.; Fowler, P. W.

10.1101/2025.01.30.635633 — microbiology — Posted on 2025-05-09

4382 Lateralised modulation of posterior alpha oscillations by closed loop auditory stimulation during memory retention

Hebron, H.; Dimitrova, R.; Jaramillo, V.; Dijk, D.-J.; Violante, I. R.

10.1101/2025.05.07.652437 — neuroscience — Posted on 2025-05-09

4383 Novel artificial selection method improves function of simulated microbial communities

Vessman, B.; Guridi-Fernandez, P.; Arias-Sanchez, F. I.; Mitri, S.

10.1101/2023.01.08.523165 — evolutionary biology — Posted on 2025-05-09

4384 Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Marocco, F.; Garbo, S.; Montaldo, C.; Colantoni, A.; Quattrocchi, L.; Gaboardi, G.; Sabarese, G.; Cicchini, C.; Lecce, M.; Carnevale, A.; Paolini, R.; Tartaglia, G. G.; Battistelli, C.; Tripodi, M.

10.1101/2024.11.15.623754 — molecular biology — Posted on 2025-05-09

4385 An integrative genomic and chemical similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

Steffen, K.; Rangel-Grimaldo, M.; Sauters, T. J. C.; Rinker, D.; Raja, H. A.; Graf, T. N.; Gumilang, A.; Riedling, O. L.; Goldman, G.; Oberlies, N. H.; Rokas, A.

10.1101/2025.05.08.652894 — microbiology — Posted on 2025-05-09

4386 Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs

Winski, C. J.; Stuckey, P. V.; Marrufo, A. M.; Agyei, G.; Ross, R. L.; Urmi, T.; Chapman, S.; Santiago-Tirado, F. H.

10.1101/2024.06.17.599354 — microbiology — Posted on 2025-05-09

4387 Characterisation of transgenic lines labelling reticulospinal neurons in larval zebrafish

Collins, E. M.; Silva, P. T.; Ostrovsky, A. D.; Renninger, S. L.; Tomas, A. R.; Diez del Corral, R.; Orger, M. B.

10.1101/2024.12.20.629714 — neuroscience — Posted on 2025-05-09

4388 Microvascular homeostasis is compromised in pancreatic islets in a mouse model of beta cell loss and low-grade inflammation

Mateus Goncalves, L.; Shirvaikar, I.; Sideris, K.; Pereira, E.; Slak Rupnik, M.; Almaca, J.

10.1101/2025.05.05.652204 — physiology — Posted on 2025-05-09

4389 Genome Dynamics and Chromosome Structural Variations in Histoplasma ohiense, a fungal pathogen of humans

Heater, S.; Voorhies, M.; Sil, A.

10.1101/2025.05.05.652209 — genomics — Posted on 2025-05-09

4390 Fungal communities in long-term contaminated soils within a former radium production area

Rybak, A.; Maystrenko, T.; Rasova, E.; Belykh, E.; Velegzhaninov, I.

10.1101/2025.05.05.652156 — ecology — Posted on 2025-05-09

4391 Conservation of symmetry breaking at the level of chromatin accessibility between fly species with unrelated anterior determinants

Amiri, E. E.; Tenger-Trolander, A.; Li, M.; Julian, A. T.; Kasan, K.; Sanders, S. A.; Blythe, S. A.; Schmidt-Ott, U.

10.1101/2025.01.13.632851 — developmental biology — Posted on 2025-05-09

4392 Sex-dependent neural plasticity in response to damage

Recatala-Martinez, M.; Bosch, M.; Gaspar, P.; Mineo, A.; Rios, S.; Miguel-Aliaga, I.; Morey, M.

10.1101/2025.05.05.652027 — neuroscience — Posted on 2025-05-09

4393 A trio-binning approach for Cannabis genome de novo assembly reveals extensive structural variation, and defines paralog cohorts with very good resolution

Pike, B.; Kozik, A.; Teran, W.

10.1101/2025.05.04.652121 — plant biology — Posted on 2025-05-09

4394 Long-range genomic loci stochastically assemble into combinatorial forms of chromosome skeleton

Zhang, J.; Wang, S.; Watkins, S. C.; Xing, J.

10.1101/2025.02.10.637328 — biophysics — Posted on 2025-05-09

4395 TS2CG as a membrane builder

Schuhmann, F.; Stevens, J. A.; Rahmani, N.; Lindahl, I.; Brown, C. M.; Brasnett, C.; Anastasiou, D.; Bravo Vidal, A.; Geiger, B. J.; Marrink, S.-J.; Pezeshkian, W.

10.1101/2025.04.16.649160 — biophysics — Posted on 2025-05-09

4396 The information content of species: formal definitions of pangenome complexity track with bacterial lifestyle

Narechania, A.; Bobo, D.; Gilbert, T.; Gopalakrishnan, S.

10.1101/2025.03.28.645969 — genomics — Posted on 2025-05-09

4397 An Accessible 3D HepG2/C3A Liver Spheroid Model Supporting the Complete Intrahepatocytic Lifecycle of Plasmodium falciparum

Caygill, C. H.; Alqurashi, S. O.; Adolfi, A.; Carson, J.; Sturm, A.; Evans, D. S.; Jinks, J. B.; Dechering, K. J.; Reimer, L.; Pennington, S. H.; Sharma, P.; Ward, S. A.; Biagini, G.

10.1101/2024.11.06.621813 — microbiology — Posted on 2025-05-09

4398 White matter microstructure and macrostructure brain charts across the human lifespan

Kim, M. E.; Gao, C.; Ramadass, K.; Newlin, N. R.; Kanakaraj, P.; Bogdanov, S.; Rudravaram, G.; Archer, D.; Hohman, T. J.; Jefferson, A. L.; Morgan, V. L.; Roche, A.; Englot, D. J.; Resnick, S. M.; Beason-Held, L. L.; Cutting, L.; Barquero, L. A.; D'arcangel, M. A.; Nguyen, T. Q.; Humphreys, K. L.; Niu, Y.; Vinci-Booher, S.; Cascio, C. J.; The HABS-HD Study Team, ; Alzheimers Disease Neuroimaging Initiative, ; The BIOCARD Study Team, ; Li, Z.; Vandekar, S. N.; Zhang, P.; Gore, J. C.; Landman, B. A.; Schilling, K. G.

10.1101/2025.05.08.652953 — neuroscience — Posted on 2025-05-09

4399 Conserved and lineage-restricted gene regulatory programs modulate developmental cnidocyte specification in Nematostella vectensis.

Danladi, B.; Al-Shaer, L.; Havrilak, J. A.; Faltine-Gonzalez, D. Z.; Jia, K.; Forwood, W.; Dubuc, T.; Musser, J.; Layden, M. J.

10.1101/2025.05.08.652877 — evolutionary biology — Posted on 2025-05-09

4400 Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris, Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus)

Barker, K. S.; Patterson, H. P.; Morschhauser, J.; Cuomo, C. A.; Wiederhold, N. P.; Rogers, P. D.

10.1101/2025.05.07.652603 — microbiology — Posted on 2025-05-09

4401 Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression

Rusch, J.; Thanintorn, N.; Kuok, C.; Tsatskis, Y.; Hou, H.; Wilson, M. D.; Julick, C.; McNeill, H.

10.1101/2025.05.08.652952 — developmental biology — Posted on 2025-05-09

4402 Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera

Ronceray, N.; Bennani, S.; Mitsioni, M. F.; Siegel, N.; Marcaida, M. J.; Bruschini, C.; Charbon, E.; Roy, R.; Dal Peraro, M.; Acuna, G. P.; Radenovic, A.

10.1101/2024.09.17.613468 — biophysics — Posted on 2025-05-09

4403 RNAcompare: Integrating machine learning algorithms to unveil the similarities of phenotypes based on clinical, multi-omics using Rheumatoid Arthritis and Heart Failure as Case Studies

Tang, M.

10.1101/2025.04.02.646760 — bioinformatics — Posted on 2025-05-09

4404 Genetically diverse populations hold the keys to climatic adaptation: a lesson from a cosmopolitan raptor

Corval, H.; Cumer, T.; Topaloudis, A.; Collart, F.; Guisan, A.; Roulin, A.; Goudet, J.

10.1101/2023.03.17.533108 — evolutionary biology — Posted on 2025-05-09

4405 Chronic broadband noise increases the fitness of a laboratory-raised freshwater zooplankton

Prosnier, L.; Rojas, E.; Valero, O.; Medoc, V.

10.1101/2022.11.19.517212 — ecology — Posted on 2025-05-09

4406 Parsing glomerular and tubular structure variability in high-throughput kidney organoid culture

Uusi-Rauva, K.; Pirttiniemi, A.; Hassinen, A.; Trokovic, R.; Lehtonen, S.; Kallijarvi, J.; Lehto, M.; Fellman, V.; Groop, P.-H.

10.1101/2025.05.05.652160 — developmental biology — Posted on 2025-05-09

4407 Receptor stoichiometry predicts artery-typical vulnerability to altered Notch signaling during smooth muscle differentiation.

Sanlidag, S.; Virtanen, N.; Hoursan, H.; Ristori, T.; Sjoqvist, M.; Loerakker, S.; Sahlgren, C.

10.1101/2025.05.05.652186 — developmental biology — Posted on 2025-05-09

4408 METTL9 sustains vertebrate neural development primarily via non-catalytic functions

Pandolfini, L.; Codino, A.; Spagnoletti, L.; Olobardi, C.; Cuomo, A.; Santos- Rosa, H.; Palomba, M.; Margaroli, N.; GIROTTO, S.; Scarpelli, R.; Luan, S.-L.; Crocco, E.; Bianchini, P.; Bannister, A. J.; Gustincich, S.; Kouzarides, T.; Rizzo, R.; Barbieri, I.; Cremisi, F.; Vignali, R.

10.1101/2025.05.05.652220 — developmental biology — Posted on 2025-05-09

4409 Adhesion-derived condensates control component availability to regulate adhesion dynamics

Dibus, M.; Enkavi, G.; Chastney, M.; Vattulainen, I.; Ivaska, J.

10.1101/2025.05.08.652869 — cell biology — Posted on 2025-05-09

4410 IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition

Salloum, Y.; Gros, G.; Quintero-Castillo, K.; Garcia Baudino, C.; Rabahi, S.; Janardhana Kurup, A.; Diabangouaya, P.; Perez-Pascual, D.; Morales, R. A.; Boekhorst, J.; Villablanca, E.; Ghigo, J.-M.; Feijoo, C. G.; Brugman, S.; Hernandez Cerda, P. P.

10.1101/2025.05.05.652124 — immunology — Posted on 2025-05-09

4411 DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci

Rambarack, N.; Fodder, K.; Murthy, M.; Toomey, C.; de Silva, R.; Heutink, P.; Humphrey, J.; Raj, T.; Lashley, T.; Bettencourt, C.

10.1101/2025.01.21.634065 — neuroscience — Posted on 2025-05-09

4412 Machine Learning Meets Pharmacokinetics: A Comparative Analysis of Predictive Models for Plasma Concentration-Time Profiles

Jost, F.; Giegerich, C.; Grebner, C.; Matter, H.; Cordes, H.

10.1101/2025.05.05.652167 — systems biology — Posted on 2025-05-09

4413 Multiomic profiling of hypoxic glioblastoma stem cells reveals expansion of subpopulations with distinct epigenetic and CNV profiles

Corseri, A.; Moore, T. W.; Szczepanski, N.; Hwang, H.; Zdon, A.; Yardimci, G.; Tapinos, N.

10.1101/2025.05.05.652238 — cancer biology — Posted on 2025-05-09

4414 SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer

Nakamichi, S.; von Muhlinen, N.; Yamada, L.; Melamed, J. R.; Papp, T. E.; Parhiz, H.; Weissman, D.; Horikawa, I.; Harris, C. C.

10.1101/2025.05.05.652234 — cancer biology — Posted on 2025-05-09

4415 Single-molecule FRET-tracking of InlB-activated MET receptors in living cells

Li, Y.; Dietz, M. S.; Barth, H.-D.; Niemann, H. H.; Heilemann, M.

10.1101/2025.05.06.652421 — biophysics — Posted on 2025-05-09

4416 Molecular mechanism of exchange coupling in CLC chloride/proton antiporters

Aydin, D.; Chien, C.-T.; Kreiter, J.; Nava, A.; Portasikova, J. M.; Fojtik, L.; Salcedo, C. M.; Man, P.; Dror, R. O.; Chiu, W.; Maduke, M.

10.1101/2025.05.08.652968 — biophysics — Posted on 2025-05-09

4417 In silico discovery of compounds targeting NPSL2: a regulatory element in the human oncomiR-1 primary microRNA.

Arhin, G.; Keane, S. C.

10.1101/2025.05.07.652683 — biophysics — Posted on 2025-05-09

4418 Erasable Synthetic Serum Markers

Nouraein, S.; Lee, S.; Li, H.; Saenz, V.; Raisley, E. K.; Costa, V. D.; Szablowski, J. O.

10.1101/2025.05.08.652140 — bioengineering — Posted on 2025-05-09

4419 Resource distribution unifies optimal offspring size and bacterial aging

Sakal, T.; Proulx, S. R.

10.1101/2023.06.28.546398 — evolutionary biology — Posted on 2025-05-09

4420 Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior

Nair, S. R.; Munoz, A. P.; Martineau, S.; Nasr, M.; Clemens, J.

10.1101/2025.05.08.652884 — neuroscience — Posted on 2025-05-09

4421 Brain activation for language and its relationship to cognitive and linguistic measures

Balboni, I.; Rampinini, A.; Kepinska, O.; Berthele, R.; Golestani, N.

10.1101/2024.12.31.630909 — neuroscience — Posted on 2025-05-09

4422 Large-Scale Maps of Altered Cortical Dynamics in Early-Stage Psychosis Are Related to GABAergic and Glutamatergic Neurotransmission

Arazi, A.; Toso, A.; Grent-'t-Jong, T.; Uhlhaas, P. J.; Donner, T. H.

10.1101/2024.07.15.603513 — neuroscience — Posted on 2025-05-09

4423 Synchronous Ensembles of Hippocampal CA1 Pyramidal Neurons During Novel Exploration

Chen, E.-L.; Chen, T.-W.; Schreiter, E. R.; Lin, B.-J.

10.1101/2024.02.07.579313 — neuroscience — Posted on 2025-05-09

4424 The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.

Kitto, E. S.; Huang, S.; Bhandari, M.; Tian, C.; Cox, R. L.; Beydoun, S.; Wang, E.; Shave, D.; Miller, H. A.; Easow, S. A.; Henry, E.; Schaller, M. L.; Leiser, S. F.

10.1101/2025.05.04.652087 — physiology — Posted on 2025-05-09

4425 Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia

Koedijk, J. B.; Barneh, F.; Meesters-Ensing, J. I.; van Tuil, M.; Sonneveld, E.; Lambo, S.; Perzolli, A.; Schweighart, E. K.; Ferrao Blanco, M. N.; van der Meulen, M.; Deli, A.; Haasjes, E.; Bang Christensen, K.; de Groot-Kruseman, H. A.; Meshinchi, S.; Hasle, H.; Belderbos, M.; Luesink, M.; Goemans, B. F.; Nierkens, S.; Hehir-Kwa, J.; Zwaan, C. M.; Heidenreich, O.

10.1101/2025.05.04.652110 — cancer biology — Posted on 2025-05-09

4426 Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers

Kim, J.; Oh, J.; Jang, D.; Shin, S.; Lee, S.-J.; Lee, S. E.; Yang, Y.; Kim, D.; Choi, A.-J.; Jung, H. R.; Oh, Y.; Cho, S.-Y.

10.1101/2025.05.04.652100 — cancer biology — Posted on 2025-05-09

4427 Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy

Yamashita, K.; Brender, J. R.; Saida, Y.; Otowa, Y.; Kazumasa, H.; Ito, T.; Yamamoto, K.; Merkle, H.; Linehan, W. M.; Krishna, M. C.; Kishimoto, S.

10.1101/2025.05.04.652150 — cancer biology — Posted on 2025-05-09

4428 BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

Dacheux, M.; Wu, M.-J.; Scherzer, M. T.; Nillson, M.; Murphy, B.; Schuman, S.; Ju, Z.; Bivona, T.; Lito, P.; Gumbleton, M.; Puri, S.; Akerley, W.; Wang, J.; Wang, K.; Heymach, J. V.; Kinsey, C. G.; Negrao, M. V.; McMahon, M.; Vaishnavi, A.

10.1101/2025.05.04.652129 — cancer biology — Posted on 2025-05-09

4429 Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer

Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.

10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-05-09

4430 Deep learning inference of cell type-specific gene expression from breast tumor histopathology

Wang, A. T.; Dhruba, S. R.; Wang, K.; Campagnolo, E. M.; Shulman, E. D.; Ruppin, E.

10.1101/2025.05.04.652089 — cancer biology — Posted on 2025-05-09

4431 Medium-assisted tumbling controls bacteria exploration in a complex fluid

Urra, H.; Darnige, T.; Benoit-Gonin, X.; Laurent, J.; Dawson, A.; Poon, W. C. K.; Clement, E.

10.1101/2025.05.04.652133 — biophysics — Posted on 2025-05-09

4432 Micron-scale, liquid-liquid phase separation in ternary lipid membranes containing DPPE

Goetz, G. J.; Naomi, S.; Madrigal, A. M.; Chang, C. L. A.; Cornell, C. E.; Keller, S. L.

10.1101/2025.05.08.652930 — biophysics — Posted on 2025-05-09

4433 Loading causes molecular damage in fibrin fibers

Norouzi, S.; Lohr, M. J.; Mohamed, M. I.; Jennings, C. M.; Wang, D.; Ren, P.; Rausch, M. K.; Parekh, S. H.

10.1101/2025.05.08.652948 — biophysics — Posted on 2025-05-09

4434 Hierarchical Heterogeneities in Spatio-Temporal Dynamics of the Cytoplasm

Moeckel, C.; Biswas, A.; Reber, S.; Chechkin, A.; Zaburdaev, V.; Guck, J.

10.1101/2025.05.08.652886 — biophysics — Posted on 2025-05-09

4435 Optical single-channel recording via diffusional confinement in membrane tethers

Howell, M. R.; Cohen, A. E.

10.1101/2025.05.07.652649 — biophysics — Posted on 2025-05-09

4436 Comparing PAS domain coupled intrinsic dynamics in bHLH PAS domain transcription factor complexes

Sudarsanam, K.; Srivastava, A.; Tiwari, S. P.

10.1101/2025.05.07.652577 — biophysics — Posted on 2025-05-09

4437 Generating 3D Models of Carbohydrates with GLYCAM-Web

Grant, O. C.; Wentworth, D.; Holmes, S. G.; Kandel, R.; Sehnal, D.; Wang, X.; Xiao, Y.; Sheppard, P.; Grelsson, T.; Coulter, A.; Miller, G.; Foley, B. L.; Woods, R. J.

10.1101/2025.05.08.652828 — biophysics — Posted on 2025-05-09

4438 Single-molecule Mechanostructural Fingerprinting of Nucleic Acid Conformations

Shrestha, P.; Shih, W.; Wong, W.

10.1101/2025.05.08.652980 — biophysics — Posted on 2025-05-09

4439 A pseudouridine synthase shapes tRNA structural dynamics through both catalysis and remodeling

Dennis, E. M.; Nieves, N. E. C.; Vaaler, A. L.; Kadrmas, M.; Barry, M. L.; Garcia, D. M.; Widom, J. R.

10.1101/2025.05.06.652307 — biophysics — Posted on 2025-05-09

4440 Structural basis for membrane microdomain formation by a human Stomatin complex

Fu, Z.; Stonger, J.; Li, S.

10.1101/2025.05.07.652726 — biophysics — Posted on 2025-05-09

4441 Myelin Mapping in the Human Brain Using an Empirical Extension of the Ridge Regression Theorem

Hampton, G. S.; Neff, R.; Song, Z.; Bouhrara, M.; Balan, R.; Spencer, R. G.

10.1101/2025.05.08.652955 — biophysics — Posted on 2025-05-09

4442 Streamlining Multiplexed Tissue Image Analysis with PIP{Sigma}X: An Integrated Automated Pipeline for Image Processing and EXploration for Diverse Tissue Types

Mardamshina, M.; Ballllosera Navarro, F.; Martinez Casals, A.; Avenel, C.; Wahlby, C.; Lundberg, E.

10.1101/2025.05.04.652145 — bioinformatics — Posted on 2025-05-09

4443 Application of spatial transcriptomics across organoids: a high-resolution spatial whole-transcriptome benchmarking dataset

Nucera, M. R. R.; Charitakis, N.; Leung, R.; Leichter, A.; Tuano, N.; Walkiewicz, M.; Sawant, V.; Rowley, L.; Scurr, M.; Er, P.; Tan, K.; Sutton, R.; Ahmad, F.; Saxena, R.; Maytum, A.; Turner, D.; Voges, H.; Nim, H.; Sun, X.; Yang, B.; Li, K.; Ball, G.; Elefanty, A.; Lamande', S.; Lawlor, K.; Vanslambrouck, J.; Mills, R.; Ng, E.; Stanley, E.; Werder, R.; Little, M.; Elliott, D.; Porrello, E.; Faux, M.; Eisenstat, D.; Velasco, S.; Rossello, F.; Ramialison, M.

10.1101/2025.05.04.651803 — bioinformatics — Posted on 2025-05-09

4444 IsoBayes: a Bayesian approach for single-isoform proteomics inference

BOLLON, J.; SHORTREED, M. R.; JORDAN, B. T.; MILLER, R.; JEFFERY, E.; CAVALLI, A.; SMITH, L. M.; DEWEY, C.; SHEYNKMAN, G. M.; Tiberi, S.

10.1101/2024.06.10.598223 — bioinformatics — Posted on 2025-05-09

4445 multideconv - an integrative pipeline for combining first and second generation cell type deconvolution results

Hurtado, M.; Essabbar, A.; Khajavi, L.; Pancaldi, V.

10.1101/2025.04.29.651220 — bioinformatics — Posted on 2025-05-09

4446 A plug-and-play transepithelial/transendothelial electric resistance (TEER)-upgraded organ-on-chip system to measure barrier dynamics in real-time

Kaden, T.; Besser, S.; Abdo, N.; Mosig, A. S.; Rennert, K.; Nietzsche, S.

10.1101/2025.04.10.648170 — bioengineering — Posted on 2025-05-09

4447 Charitability, Compulsion, & the Cost of Control

Arroyo, L.; Liljeholm, M.

10.1101/2025.05.04.652123 — animal behavior and cognition — Posted on 2025-05-09

4448 A comprehensive water buffalo pangenome reveals extensive structural variation linked to population specific signatures of selection

Arshad, F.; Jayaraman, S.; Talenti, A.; Owen, R.; Mohsin, M.; Mansoor, S.; Asif, M.; Prendergast, J. G.

10.1101/2025.05.04.652079 — genomics — Posted on 2025-05-09

4449 Spatially varying graph estimation for spatial transcriptomics cancer data

Acharyya, S.; Kang, J.; Baladandayuthapani, V.

10.1101/2025.05.04.652097 — genomics — Posted on 2025-05-09

4450 Natural variation in chalcone isomerase defines a major locus controlling radial stem growth variation among Populus nigra populations

Durufle, H.; Dejardin, A.; Jorge, V.; Pegard, M.; Pilate, G.; Rogier, O.; Sanchez, L.; Segura, V.

10.1101/2024.10.21.618920 — genomics — Posted on 2025-05-09

4451 Dissolved inorganic carbon driven dynamics of calcite shell formation in 12 strains of the freshwater algae Phacotus lenticularis (Chlorophyta)

Gruenert, U.; Benda, J.; Bossdorf, O.; Raeder, U.

10.1101/2025.05.04.652085 — ecology — Posted on 2025-05-09

4452 STRAIN-SPECIFIC VIRULENCE SIGNATURES OF CAMPYLOBACTER JEJUNI ASSOCIATED WITH WATERY VERSUS BLOODY DIARRHEA IN NEONATAL PIGLET MODEL

Bosquez, J. M.; Pascoe, B.; Parker, C. T.; Cooper, K. K.

10.1101/2025.04.25.650680 — microbiology — Posted on 2025-05-09

4453 Biochemical characterization and mucosal immune function of IgT in grass carp (Ctenopharyngodon idella)

Liu, B.; Zhao, J.-W.; Zhang, Y.-A.; Zhang, X.-J.

10.1101/2025.05.04.652088 — immunology — Posted on 2025-05-09

4454 Single-cell RNA sequencing reveals influences of rearing environment on cellular immunity in brown trout (Salmo trutta)

Ord, J.; Martinez, H. S.; Solbakken, M. H.; Berezenko, A.; Oberhaensli, S.; Talker, S. C.; Schmidt-Posthaus, H.; Adrian-Kalchhauser, I.

10.1101/2025.05.04.652114 — immunology — Posted on 2025-05-09

4455 Single-Cell Analysis of NK Cell Cytotoxicity in Cancer Therapy Using Microfluidic Droplets

Ozcan, R. S.; Vahedi, F.; Namakian, S.; Ashkar, A. A.; Didar, T. F.

10.1101/2025.05.04.651923 — immunology — Posted on 2025-05-09

4456 High-fidelity, but hypometric spatial localization of afterimages across saccades

Schweitzer, R.; Seel, T.; Raisch, J.; Rolfs, M.

10.1101/2025.05.04.652081 — neuroscience — Posted on 2025-05-09

4457 Induced long-term potentiation improves synaptic stability and restores network function in ALS motor neurons

Kollstrom, A. M.; Bendiksvoll Gronlie, M.; Christiansen, N.; Sandvig, A.; Sandvig, I.

10.1101/2025.05.04.652096 — neuroscience — Posted on 2025-05-09

4458 Microsaccades do not give rise to a conscious feeling of agency for their sensorimotor consequences in visual perception.

Klanke, J.-N.; Ohl, S.; Rolfs, M.

10.1101/2025.05.04.652094 — neuroscience — Posted on 2025-05-09

4459 Tracking White Matter Changes After Stereotaxic Radiosurgery inMiniature Pigs Using structural MRI, DTI, and FDG-PET

Chen, K.-H.; Yeh, C.-I.; Xiao, F.; Cheng, M.-F.; Yen, R.-F.; Ju, Y.-T.; Chen, Y.; Alder, J. R.; Barbosa, D.; Schneider, M. B.

10.1101/2025.05.04.652148 — neuroscience — Posted on 2025-05-09

4460 Deep three-photon functional imaging in the mouse cortex with adaptive optics

Atilgan, H.; Wang, J.; Hu, Q.; Tan, S.; Russell, B.; Booth, M. J.; Lak, A.

10.1101/2025.05.04.652136 — neuroscience — Posted on 2025-05-09

4461 Research on the Mechanism of Lphn1 Knockout in Inhibiting Colorectal Cancer

wang, Y.

10.1101/2024.08.07.606975 — bioinformatics — Posted on 2025-05-08

4462 The swarming behaviors of Vorticella

Tabata, T.; Maeyama, Y.

10.1101/2024.11.27.625613 — animal behavior and cognition — Posted on 2025-05-09

4463 Identification of multivariate phenotypes most influenced by mutation: Drosophila serrata wings as a case study

McGuigan, K.; Conradsen, C.

10.1101/2025.02.25.640174 — evolutionary biology — Posted on 2025-05-08

4464 Adaptive peak tracking as explanation of sparse fossil data across fluctuating ancient environments

Ergon, R.

10.1101/2024.10.30.621046 — evolutionary biology — Posted on 2025-05-08

4465 A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes

Watanabe, Y. V.; Sussman, J. H.; Anami, T.; Hattori, M.; Yamane, S.; Nishikawa, M.; Sakai, Y.; Katsuda, T.

10.1101/2025.05.07.652591 — cell biology — Posted on 2025-05-08

4466 Structure of a new capsid form and comparison with A-, B- and C-capsids clarify herpesvirus assembly and DNA translocation

Stevens, A.; Kashyap, S.; Crofut, E.; Alvarez-Cabrera, A. L.; Jih, J.; Liu, Y.; Zhou, Z. H.

10.1101/2025.03.19.644230 — microbiology — Posted on 2025-05-08

4467 MtvS Interacts With RNA Polymerase to Regulate the Francisella Type V-A CRISPR-Cas System

Brodmann, M.; Baca, C. F.; Chandanani, J.; Campbell, E. A.; Marraffini, L. A.

10.1101/2024.09.12.612765 — microbiology — Posted on 2025-05-08

4468 A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system

Taranenko, D.; Kotovskaya, O.; Kuznedelov, K.; Yanovskaya, D.; Demkina, A.; Fardeeva, S.; Mamontov, V.; Vierra, K.; Burman, N.; Li, D.; Wang, M.; Wiedenheft, B. B.; Severinov, K.; Semenova, E.; Isaev, A.

10.1101/2025.05.07.652737 — microbiology — Posted on 2025-05-08

4469 Growth rates and Metabolic Traits Differentiate Campylobacter jejuni Strains by Diarrheal Manifestation

Bosquez, J. M.; Parker, C. T.; Pascoe, B.; Cooper, K. K.

10.1101/2025.04.24.650550 — microbiology — Posted on 2025-05-08

4470 Consolidation of a recurrent choice pattern into a fixed action schema requires the orbitofrontal cortex

Tonami, R.; Aoki, S.; Abe, K.

10.1101/2025.05.08.652969 — neuroscience — Posted on 2025-05-08

4471 Pre-stimulus beta power mediates explicit and implicit perceptual biases in distinct cortical areas

Forster, C.; Stephani, T.; Grund, M.; Panagoulas, E.; Al, E.; Hofmann, S. M.; Nikulin, V. V.; Villringer, A.

10.1101/2024.06.12.598458 — neuroscience — Posted on 2025-05-08

4472 A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes.

Sangwan, S.; Rieder, H.; Moore, D.; Khanlou, N.; Novitch, B.; Geisberg, M.; Eisenberg, D.

10.1101/2025.05.05.652290 — neuroscience — Posted on 2025-05-08

4473 Scaling, but not instruction tuning, increases large language models' alignment with language processing in the human brain

Gao, C.; Ma, Z.; Chen, J.; Li, P.; Huang, S.; Li, J.

10.1101/2024.08.15.608196 — neuroscience — Posted on 2025-05-08

4474 Discover the Maze-like Pathway for Glabridin Biosynthesis

Zhang, Z.; Li, W.; Meng, F.; Jin, Y.; Sun, W.; Kuang, Q.; Ren, S.; Liu, W.; Zhang, L.; Qin, L.; Lv, B.; Jia, H.; Li, C.

10.1101/2025.05.06.652391 — synthetic biology — Posted on 2025-05-08

4475 MICLEAR: Intelligent Molecular Cytology for Intraoperative Margin Assessment of Pancreatic Ductal Adenocarcinoma

Fang, T.; Liu, D.; Chen, X.; Zhou, K.; Hao, C.; Yue, S.

10.1101/2023.12.01.569675 — biophysics — Posted on 2025-05-08

4476 Atomic Conformational Dynamics and Actin-Crosslinking Function of Alpha-Actinin Revealed by SimHS-AFMfit

Ngo, K. X.; Sumikama, T.; Vuillemot, R.; Nguyen, H. G.; Uyeda, T.; Le, N. T. P.; Grudinin, S.

10.1101/2025.04.06.647477 — biophysics — Posted on 2025-05-08

4477 All of Us diversity and scale improve polygenic prediction contextually with greatest improvements for underrepresented populations

Tsuo, K.; Shi, Z.; Ge, T.; Mandla, R.; Hou, K.; Ding, Y.; Pasaniuc, B.; Wang, Y.; Martin, A. R.

10.1101/2024.08.06.606846 — genomics — Posted on 2025-05-08

4478 No evidence for disassortative mating based on HLA genotype in a natural fertility population

Meeks, G. L.; Scelza, B.; Kichula, K. M.; Berevoescu, C.; Hardy, K.; Farias, T. D.; Harrison, G. F.; Pollock, N. R.; Font-Porterias, N.; Prall, S.; Norman, P. J.; Henn, B. M.

10.1101/2025.05.06.652536 — evolutionary biology — Posted on 2025-05-08

4479 Dogs gone wild: habitat use and ecological impacts of feral dogs in sub-Antarctic Chile

Tebelmann, H.; Kaefer, S.; Pages, A. S.; Ruiz, A. C.; Volkart, N. S.; Ganslosser, U.

10.1101/2025.05.08.652634 — ecology — Posted on 2025-05-08

4480 High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

Yi, C.; Sun, J.; Sun, M.; Zhu, L.; Ma, Y.; Wu, S.; Liu, Y.; Gao, S.; Zhang, M.; Zhang, Y.-H.; Wang, Z.; Tzung, H.; Zou, P.; Li, D.; Liu, B.; Fei, P.

10.1101/2023.11.25.568636 — cell biology — Posted on 2025-05-08

4481 Alignment of human behavior, brain, and AI models in the high-level valence processing of complex social scenes

Yargholi, E.; Mertens, L.; Van Hove, L. I.; Gunay, E. M.; Vennekens, J.; Van den Stock, J.; Op de Beeck, H.

10.1101/2025.05.08.651182 — neuroscience — Posted on 2025-05-08

4482 White matter microstructure and macrostructure brain charts across the human lifespan

10.1101/2025.05.08.652953 — neuroscience — Posted on 2025-05-08

4483 Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior

Clemens, J.; Nair, S. R.; Munoz, A. P.; Martineau, S.; Nasr, M.

10.1101/2025.05.08.652884 — neuroscience — Posted on 2025-05-08

4484 Dynamics of oscillatory power subtends multiplexing of perceptual and mnemonic information within the premotor cortex

Marc, I. B.; Giuffrida, V.; Ramawat, S.; Bardella, G.; Ferraina, S.; Brunamonti, E.

10.1101/2025.05.08.652817 — neuroscience — Posted on 2025-05-08

4485 PTEN regulates starburst amacrine cell dendrite morphology during development

Bracha, T. W.; Luong, N.; Leffler, J.; Sivyer, B.; Wright, K. M.

10.1101/2025.05.08.652956 — neuroscience — Posted on 2025-05-08

4486 Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level

Wang, Y.; Kou, H.-C.; Kuang, X.; Yao, S.; Lesnar, P.; NG, L.; Li, Y.; El-Hifnawi, L.; Chen, N.; Zhang, K.; Li, E. M.; Ben Simon, Y.; Ding, S.-L.; Wang, Q.; Karlsson, T.; Delley, R.; Williams, G.; Xiong, W.; Chen, C.; Chen, K.; Huang, Z.; Yu, Z.-F.; Xu, W.; Ahmadinia, L.; Walling-Bell, S.; Andrade, J.; Gliko, O.; Sumbul, U.; Mallory, M.; Farrell, C.; Sutton, B.; Jin, K.; Yao, Z.; Esposito, L.; Sunkin, S.; Kruse, L.; Luo, Q.; Gong, H.; Li, A.; Qu, J.; Choi, H.; Mihalas, S.; Zhuang, J.; Zeng, H.; Sorensen, S. A.

10.1101/2025.05.08.652699 — neuroscience — Posted on 2025-05-08

4487 Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data

de Groot, D. H.; Leonardo, S. X. M.; Pachkov, M.; van Nimwegen, E.

10.1101/2025.05.08.652944 — bioinformatics — Posted on 2025-05-08

4488 Molecular epidemiology of Theileria parva in Eastern Democratic Republic of Congo: Implications to the introduction of the Muguga Cocktail vaccine for East Coast Fever

Muleya, W.; Mulonga, S.; Mbao, V.; Kasereka, K. M.; Mbusa, K. H.; Namangala, B.; Salt, J.; Musoke, A. J.; Atuhaire, D. K.

10.1101/2025.05.07.652749 — molecular biology — Posted on 2025-05-08

4489 A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system

Isaev, A.; Taranenko, D.; Kotovskaya, O.; Kuznedelov, K.; Yanovskaya, D.; Demkina, A.; Fardeeva, S.; Mamontov, V.; Vierra, K.; Burman, N.; Li, D.; Wang, M.; Wiedenheft, B. B.; Severinov, K.; Semenova, E.

10.1101/2025.05.07.652737 — microbiology — Posted on 2025-05-08

4490 Design and synthesis of nanocarriers containing posaconazole against etiological agents of mucormycosis

Panahi, P.; Pourdakan, O.; Zarrinnahad, H.; Mahmoudi, S.; Aghaie, G.; Hosseini, F.; Alemzadeh, S. A.; Malek Raeesi, M.; Mirhendi, H.; Mehravi, B.

10.1101/2025.05.08.652746 — microbiology — Posted on 2025-05-08

4491 Influence of Housing, Sex, and Sampling Location on Taxonomy and Function of Adult Zebrafish Microbiomes

Gaulke, C. A.; Wanyama, J. W.; Okyere, L.; Duan, L.

10.1101/2025.05.08.652836 — microbiology — Posted on 2025-05-08

4492 Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function

Santiago-Carvalho, I.; Francisco, R.; Macedo, B. G.; Salgado, C. L.; Stoll, C. R.; Cione, M. P.; White, E.; Johnston, T.; Leff, C. L.; Silva, I.; de Souza, F. C.; D'Imperio Lima, M. R.; Lancaster, J. N.; Borges da Silva, H.

10.1101/2025.05.03.652022 — immunology — Posted on 2025-05-08

4493 Ischemic Injury Drives Tumor Growth via Accelerated Hematopoietic Aging

Newman, A. A. C.; Barcia Duran, J. G.; Von Itter, R.; Dalman, J. M.; Lim, B.; Gourvest, M.; Zahr, T.; Wang, K. M.; Zhang, T.; Albarracin, N.; Rubin, W.; Bozal, F.; Gildea, M. A.; van Solingen, C.; Moore, K. J.

10.1101/2025.05.03.652034 — immunology — Posted on 2025-05-08

4494 Targeting Lysosomal Dysfunction to Alleviate Plaque Deposition in an Alzheimer Disease Model

Fremuth, L. E.; van de Vlekkert, D.; Hu, H.; Weesner, J. A.; Annunziata, I.; d'Azzo, A.

10.1101/2025.04.28.651121 — neuroscience — Posted on 2025-05-08

4495 Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

Murano, T.; Hagihara, H.; Tajinda, K.; Takao, K.; Takamiya, Y.; Katoh, K.; Robison, A. J.; Matsumoto, M.; Namihira, M.; Miyakawa, T.

10.1101/2025.05.02.651848 — neuroscience — Posted on 2025-05-08

4496 An integrative framework linking molecular signatures and locomotory phenotypes in space-induced sarcopenia

Ball, B. K.; Khan, H. F.

10.1101/2025.05.03.652040 — systems biology — Posted on 2025-05-08

4497 Simulated Solute Tempering 2

Stratmann, D.; Moroy, G.; Tuffery, P.; Murail, S.

10.1101/2024.10.03.613476 — biophysics — Posted on 2025-05-08

4498 Harmonization of Structural Brain Connectivity through Distribution Matching

Zhou, Z.; Fischl, B.; Aganj, I.

10.1101/2024.09.05.611489 — bioengineering — Posted on 2025-05-08

4499 Differential control of RNA demethylase activity and selectivity by cofactor ascorbate

Calzini, L. O.; Warminski, M.; Kowalska, J.; Jemielity, J.; Mugridge, J. S.

10.1101/2025.05.06.652568 — biochemistry — Posted on 2025-05-08

4500 Nested small open reading frames are translated from alternative transcripts

Su, H.; Katz, S. G.; Slavoff, S. A.

10.1101/2024.10.22.619581 — biochemistry — Posted on 2025-05-08

4501 Medium-sized protein language models perform well at transfer learning on realistic datasets

Vieira, L. C.; Handojo, M. C.; Wilke, C. O.

10.1101/2024.11.22.624936 — biochemistry — Posted on 2025-05-08

4502 Female sexual agency and frequent extra-pair copulations, but no extra-pair paternity, in Nazca boobies (Sula granti)

Anderson, D. J.; Huyvaert, K. P.; Espinosa, P. M.; Westbrock, M. A.; Awkerman, J. A.; Schneider, E. G.

10.1101/2025.05.03.652052 — animal behavior and cognition — Posted on 2025-05-08

4503 Identity-by-descent captures Shared Environmental Factors at Biobank Scale

Marsico, F.; Buonaiuto, S.; Amos-Abanyie, E.; Chinthala, L.; Mohammed, A.; Genetics Center, R.; Rooney, R.; Williams, R. W.; Davis, R. L.; Finkel, T. H.; Brown, C. W.; Prins, P.; Colonna, V.

10.1101/2025.05.03.652048 — genomics — Posted on 2025-05-08

4504 Using all available evidence to solve kinship cases

Egeland, T.; Marsico, F.

10.1101/2025.05.03.652046 — genetics — Posted on 2025-05-08

4505 In vitro inhibition of the CFTR ion channel in the cervix thickens cervical mucus

Looney, R. J.; Roberts, M.; Markovetz, M.; Godiah, R.; Yao, S.; Golgotiu, K.; Wei, S.; Cellucci, C.; Han, L.

10.1101/2024.10.14.618249 — cell biology — Posted on 2025-05-08

4506 Discovery and CryoEM Structure of FPM13, a Periplasmic Metalloprotein Unique to Francisella

Clemens, D. L.; Lee, B.-Y.; Liu, X.; Zhou, Z. H.; Horwitz, M. A.

10.1101/2025.05.08.652791 — microbiology — Posted on 2025-05-08

4507 GplR1, an unusual TetR-like transcription factor in Mycobacterium abscessus, controls the production of cell wall glycopeptidolipids, colony morphology, and virulence

Shell, S.; Bar-Oz, M.; Xiao, J.; Pandey, M.; Belardinelli, J.; Jackson, M.; Oehlers, S. H.; Barkan, D.; Meir, M.

10.1101/2025.05.07.652718 — microbiology — Posted on 2025-05-08

4508 Cell cycle checkpoint activity in the malaria parasite Plasmodium falciparum

Johnson, M. K.; Naldoni, J.; Merrick, C. J.

10.1101/2025.05.08.652832 — microbiology — Posted on 2025-05-08

4509 m5C RNA Methylation Is Dysregulated by Oncogenic Herpesviruses via c-Myc Signaling to Counteract Host Antiviral Factors

Wu, Z.; Zhou, D.; He, Z.; Fiches, G.; Park, Y.; He, J.; Chen, J.; Shanaka, K.; Lepcha, T. T.; Desai, P. J.; Zhu, J.; Santoso, N.

10.1101/2025.05.07.652742 — microbiology — Posted on 2025-05-08

4510 Transcriptional Regulator, Metabolic, and Pilus Biosynthesis Genes as Candidate Virulence Markers in High-Virulence Mycobacterium abscessus

Maddox, M.; Kado, T.

10.1101/2025.05.08.652910 — microbiology — Posted on 2025-05-08

4511 The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo.

Tandon, N.; Gutierrez-Martinez, E.; Bourdely, P.; Anselmi, G.; Denisot, J.; Gerber, Y.; Helft, J.; Bens, M.; Saveanu, L.; Guermonprez, P.

10.1101/2025.05.03.652057 — immunology — Posted on 2025-05-08

4512 FGA139, a Novel Cysteine Protease Inhibitor, Exhibits Anti-Inflammatory and Neuroprotective Activity and Reveals Microglial Modulation via Multi-Omics Profiling

Canseco-Rodriguez, A.; Gonzalez, F. V.; Sanchez-Perez, A. M.

10.1101/2025.05.03.652036 — neuroscience — Posted on 2025-05-08

4513 Impact of inhibitors of histone post-translational modifications on lifespan, reproduction, and stress response in the rotifer Brachionus manjavacas

Luviano Aparicio, N.; Dryburgh, M.; McMaken, C. M.; Liguori, A.; Gribble, K. E.

10.1101/2025.05.03.652051 — physiology — Posted on 2025-05-08

4514 CRISMER: A transformer-based Interpretable Deep Learning Approach for Genome-wide CRISPR Cas-9 Off-Target Prediction and Optimization

Emtiaj, A. H.; Rafi, R. H.; Nayeem, M. A.; Rahman, M. S.

10.1101/2025.05.03.652008 — bioinformatics — Posted on 2025-05-08

4515 Synthesis and In Vitro Assessment of Triazole-Based Compounds as Potential Inhibitors of Herpes Simplex Virus Type 1

Mishra, N. U.; Sanap, K. K.; Sharma, P. C.; Kudale, T.; Kudale, J. V. T.; Biswas, A.; Bhatia, D. D.

10.1101/2025.05.03.652007 — biochemistry — Posted on 2025-05-08

4516 Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii

Rouleau, F. D.; Dube, A. K.; Pageau, A.; Desautels, L.; Dufresne, P. J.; Landry, C. R.

10.1101/2025.05.07.652661 — biochemistry — Posted on 2025-05-08

4517 Nuclear Argonaute:miRNA complexes recognize target sequences within chromatin and silence gene expression

Corey, D. R.; Hofman, C.; Tse, V.; Bryl, R.; Hu, J.

10.1101/2025.05.08.652285 — biochemistry — Posted on 2025-05-08

4518 Adaptive Asymmetric Adjustment in Affective Evaluation and Reciprocity for Altruistic Behaviors from Exogenous Uncertainty to Certainty

Liu, X.; Liao, R.; Nan, Y.; Fang, Y.; Hu, Y.; Zhou, X.; Gao, X.

10.1101/2025.05.03.651994 — animal behavior and cognition — Posted on 2025-05-08

4519 Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging

Zhang, Z.; Epstein, A.; Schaefer, C.; Abdulraouf, A.; Jiang, W.; Zhou, W.; Cao, J.

10.1101/2025.05.04.652093 — genomics — Posted on 2025-05-08

4520 Integrative analysis of RNA binding proteins identifies DDX55 as a novel regulator of 3'UTR isoform diversity

Gazzara, M. R.; Cater, T.; Mallory, M. J.; Barash, Y.; Lynch, K. W.

10.1101/2025.05.06.652471 — genomics — Posted on 2025-05-08

4521 Loss of Vertically-Inherited Totiviruses and Toxin-Encoding Satellites in Killer Yeast Evidences Intracellular Conflict in Natural Populations

Travers Cook, T.; Knight, S.; Lee, S.; Jucker, J.; Schlegel, T.; Jokela, J.; Buser, C.

10.1101/2025.05.03.652063 — evolutionary biology — Posted on 2025-05-08

4522 Leaving No Stone Unturned: Delineating the Distribution Range of the White Striped Viper-Gecko (Hemidactylus albofasciatus).

Amberkar, P.; Mandke, S.

10.1101/2025.05.03.651999 — ecology — Posted on 2025-05-08

4523 Atomic Structure and Phospholipid Binding Properties of the Francisella Type VI Secretion System Effector Protein PdpC

Liu, X.; Clemens, D. L.; Lee, B.-Y.; Xia, X.; Fan, H.; Feng, K. Y.; Horwitz, M. A.; Zhou, Z. H.

10.1101/2025.05.08.652963 — microbiology — Posted on 2025-05-08

4524 Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes

Richman, A. R.; Kogut, S.; Edwards, T.; Boyd, J.; Rodriguez, P.; Mariani, M.; Shipley, M. A.; Manuel, K. A.; Ye, Z. A.; Bloom, D. C.; Frietze, S.; Neumann, D. M.

10.1101/2025.05.08.652945 — microbiology — Posted on 2025-05-08

4525 MicroProphet: A Digital Twin Framework for Predicting Microbial Community Dynamics with Personalized Precision

Zhang, Y.; Zhou, K.; Chen, X.; Zhang, H.; Chen, X.; Ning, K.

10.1101/2025.05.08.652793 — microbiology — Posted on 2025-05-08

4526 A bacterial CARD-NLR immune system controls the release of gene transfer agents

Banks, E. J.; Bardy, P.; Tran, N. T.; Nguyen, P. M.; Maqbool, A.; Le, T. B. K.

10.1101/2025.05.08.652646 — microbiology — Posted on 2025-05-08

4527 HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

Mason, S. J.; Sreeram, S.; Niazi, F.; Leskov, K.; Levine, A. D.; Karn, J.; Valadkhan, S.

10.1101/2025.05.08.651477 — microbiology — Posted on 2025-05-08

4528 Associations between floor material and E. coli contamination in rural Bangladeshi households

Tazin, S.; Islam, M.; Pickering, A. J.; Kwong, L. H.; Mertens, A.; Niven, C.; Arnold, B. F.; Hubbard, A. E.; Alam, M.; Sen, D.; Islam, S.; Rahman, M.; Unicomb, L.; Luby, S. P.; Benjamin-Chung, J.; Ercumen, A.

10.1101/2025.05.07.652756 — microbiology — Posted on 2025-05-08

4529 Characterization of the glycoproteins of novel fish influenza B-like viruses

Singh, G.; Huang, J.; Bhavsar, D.; Vasilev, K.; Ferguson, J.; Boons, G.-J.; Simon, V.; de Vries, R. P.; Han, J.; Ward, A.; Krammer, F.

10.1101/2025.05.08.652883 — microbiology — Posted on 2025-05-08

4530 An integrative genomic and chemical similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

Steffen, K.; Rangel-Grimaldo, M.; Sauters, T. J. C.; Rinker, D.; Raja, H. A.; Graf, T. N.; Gumilang, A.; Riedling, O. L.; Goldman, G.; Oberlies, N. H.; Rokas, A.

10.1101/2025.05.08.652894 — microbiology — Posted on 2025-05-08

4531 MAIT cell responses to intracellular and extracellular pathogens are mediated by distinct antigen presenting cells

Haas, D.; Melamed, J.; LeBlanc, G.; Arun, N.; Perkowski, A. J.; Aube, J.; Mack, M.; Constantinides, M. G.

10.1101/2025.05.03.652000 — immunology — Posted on 2025-05-08

4532 Multi-step antibody class switching in a primary human response is restricted after IGHG2 and dependent on B cell maturation stage.

Garcia, G. M.; Ng, J. C.; Stewart, A. T.; Sinclair, E.; Blair, P.; Kateregga, D.; Gander, A.; Kipling, D.; Guo, D.; Servius, L.; Piper, C.; Baig, Z.; Fraternali, F.; Mauri, C.; Dunn-Walters, D.

10.1101/2025.05.07.652638 — immunology — Posted on 2025-05-08

4533 Dual-Resonance Shapes REM Sleep: A Mechanistic Link Between Homeostasis, Circadian Phase, and Sleep Deficit.

Zhdanova, I. V.; Kharchenko, V.

10.1101/2025.05.02.651911 — neuroscience — Posted on 2025-05-08

4534 A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes.

Sangwan, S.; Rieder, H.; Moore, D.; Khanlou, N.; Novitch, B.; Geisberg, M.; Eisenberg, D.

10.1101/2025.05.05.652290 — neuroscience — Posted on 2025-05-08

4535 Adropin protects against cardiac metabolic remodeling and dysfunction in HFpEF

Mushala, B. A.; Stoner, M. W.; Manning, J. R.; Bugga, P.; Bhattarai, N.; Sharifi-Sanjani, M.; McMahon, B.; Vandevender, A.; Mullett, S. J.; Kaufman, B. A.; Shiva, S. S.; Zhang, C.; Goetzman, E. S.; Chan, S. Y.; Gelhaus, S. L.; Jurczak, M. J.; Scott, I.

10.1101/2025.05.03.652038 — physiology — Posted on 2025-05-08

4536 Delayed Extracellular Matrix Negative Feedback Contributes to Nascent Adhesion Dynamics: Mathematical Modeling and Analysis

Andasari, V.; Syafiie, S.

10.1101/2025.05.06.652413 — biophysics — Posted on 2025-05-08

4537 In silico analysis and Predictive linkage of Deubiquitinating Enzymes underlying Early Development

Munavar-K, F.; Lenka, N.

10.1101/2025.05.03.652026 — bioinformatics — Posted on 2025-05-08

4538 NanoLoop: A deep learning framework leveraging Nanopore sequencing for chromatin loop prediction

Huang, W.; Tang, L.; Hill, M. C.; Zhang, Y.; Xie, J.; Li, M.

10.1101/2025.05.03.651998 — bioinformatics — Posted on 2025-05-08

4539 Deep learning inference of miRNA expression from bulk and single-cell mRNA expression

Ripan, R. C.; Athaya, T.; Li, x.; Hu, H.

10.1101/2025.05.03.652014 — bioinformatics — Posted on 2025-05-08

4540 High-Throughput Multiomics Profiling of Model Systems Using the AVITI24 Platform

Lopez, T.; Honigfort, D.; Mah, A.; Thompson, C.; Dien, V.; Dawood, M.; Frankel, E.; Fuller, D.; Jamison, C.; Kelley, R.; Kwon, J.; Liu, Y.; Ren, P.; Saha, S.; Wang, H.; Wong, J.; Zhao, D.; Abtahi, M.; Altomare, A.; Bajari, R.; Bellizzi, A.; Bracamonte, S.; Bradfield, A.; Brown-Greaves, C.; Bui, C.; Charov, K.; Constandse, R.; Cullion, K.; Damron, W.; Dangelo, M.; Davis, L.; Dawood, N.; Dhonde, R.; Elango, K.; Espinosa, S.; Garcia, F.; Gavrila, V.; Gomez, L.; Hastings, D.; Hoang, D.; Juan, W.; Kia, A.; Kim, M.; Krivit, M.; Lama, R.; Mandla, K.; Martinez, A.; Mass, M.; Miller, A.; Neysmith, J.;

10.1101/2025.05.03.651997 — genomics — Posted on 2025-05-08

4541 No Evidence of Direct Activation of Human Neutrophil Responses by Multivalent Prefusion Trimeric SARS-CoV-2 Spike Protein ex vivo

Fortin, A.; Huot, S.; Caron, E.; Laflamme, C.; Pagliuzza, A.; Chomont, N.; Gilbert, C.; Zhang, B.; Kwong, P. D.; Pouliot, M.; Grandvaux, N.

10.1101/2025.05.08.652856 — immunology — Posted on 2025-05-08

4542 C57 and DBA mouse strains express distinct cocaine avoidance phenotypes in an operant runway independent of differences in striatal dynorphin-enkephalin balance

Remmers, B. C.; Choi, I. B.; Matsumura, K.; Nicot, A.; Cox, S.; Dobbs, L. K.

10.1101/2025.05.03.652074 — neuroscience — Posted on 2025-05-08

4543 A computational framework for mapping isoform landscape and regulatory mechanisms from spatial transcriptomics data

Su, J.; Qu, Y.; Schertzer, M. D.; Yang, H.; Jiang, J.; Lhakhang, T.; Nelson, T. M.; Park, S.; Lai, Q.; Fu, X.; Choi, S.-W.; Knowles, D. A.; Rabadan, R.

10.1101/2025.05.02.651907 — bioinformatics — Posted on 2025-05-08

4544 BioMedTools: a language model-powered community for biomedical computational tools

Liu, S.; Xing, H.; Han, M.; Zhang, D.; Gong, L.; Liu, D.; Chen, J.; Cai, P.; Hu, Q.-N.

10.1101/2025.05.02.651919 — bioinformatics — Posted on 2025-05-08

4545 Next generation statistical framework for next generation spatial transcriptomics data

Mangane, F.; Bost, P.

10.1101/2025.05.02.651852 — bioinformatics — Posted on 2025-05-08

4546 Computational Screening of Filamin Mechanical Binding Proteins using AlphaFold2

Johnson, J.; Gonzalez-Morales, N.

10.1101/2025.05.02.651884 — bioinformatics — Posted on 2025-05-08

4547 DIST: Distance-based Inference of Species Trees

de Jong, M. J.; Janke, A.

10.1101/2025.05.02.651899 — bioinformatics — Posted on 2025-05-08

4548 Resolving Inflammation: The Impact of Antiretroviral Therapy on Macrophage Traffic In and Out of the CNS.

Wallis, Z.; Midkiff, C.; Zhao, M.; Kim, S. O.; Amadeck, A.; Wang, Y.; Jakubowski, M.; Burdo, T.; Miller, A.; Li, Q.; Alvarez, X.; Blair, R.; Williams, K.

10.1101/2025.05.02.651872 — immunology — Posted on 2025-05-08

4549 Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation

Hovde, M. J.; Bolland, D. E.; Kleinsasser, C. D.; Shetty, M.; Blackwell, A. C.; Golovko, M. Y.; Golovko, S. A.; Brown, C. R.; Foster, J. D.; Vaughan, R. A.

10.1101/2025.05.02.651918 — neuroscience — Posted on 2025-05-08

4550 A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain

Brann, D. H.; Tsukahara, T.; Tau, C.; Kalloor, D.; Lubash, R.; Thamarai Kannan, L.; Klimpert, N.; Kollo, M.; Escamilla-Del-Arenal, M.; Bintu, B.; Bozza, T.; Datta, S. R.

10.1101/2025.05.02.651738 — neuroscience — Posted on 2025-05-08

4551 Age differences in motivation drive performance during the sustained attention to response task

Hanzal, S.; Thut, G.; Learmonth, G.; Harvey, M.

10.1101/2025.05.02.651857 — neuroscience — Posted on 2025-05-08

4552 A joint probabilistic model of human scene and object recognition via non-hierarchical residual computation

Nishida, K.; Motoyoshi, I.

10.1101/2025.05.02.651866 — neuroscience — Posted on 2025-05-08

4553 Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development

Yan, B.; Yuan, Q.; Kaur, P.; Mckee, A. R.; Shabashvili, D. E.; Guryanova, O. A.

10.1101/2025.05.02.651715 — pathology — Posted on 2025-05-08

4554 CaneCestry : A Web-based Toolbox for Efficient Pedigree Analysis and Visualization.

Taylor, Z.; Blanchard, B.; Dhungana, A.; Kimbeng, C.

10.1101/2025.05.02.651868 — bioinformatics — Posted on 2025-05-08

4555 Abstinence from Substance Use & The Value of Control

Giovanni, E. M.; Liljeholm, M.

10.1101/2025.05.02.651720 — animal behavior and cognition — Posted on 2025-05-08

4556 EnrichSci: Transcript-guided Targeted Cell Enrichment for Scalable Single-Cell RNA Sequencing

Liao, A.; Zhang, Z.; Sziraki, A.; Abdulraouf, A.; Xu, Z.; Lu, Z.; Zhou, W.; Cao, J.

10.1101/2025.05.02.651937 — genomics — Posted on 2025-05-08

4557 WITHDRAWN: Investigation of coronaviruses, paramyxoviruses and poxviruses in free-ranging anteaters and armadillos: a search for the unknown and zoonotic implications

Martins, N. B.; Alves, M. H.; De Navasquez, L. M. L.; Linhares, Y. S.; Caiaffa, M. G.; Soresini, G.; Kluyber, D.; Yogui, D. R.; Alves, A. C.; Lobo, A. C. M.; Catao-Dias, J. L.; Benavides, J. A.; Desbiez, A. L. J.; Brandao, P. E.; Hora, A. S. d.

10.1101/2025.02.26.640290 — molecular biology — Posted on 2025-05-08

4558 In vivo production of an anti-HIV antibody from primate hematopoietic cells by non-viral knock-in

Castelli, J. M.; Poljakov, K.; Youngseo, J.; Cassidy, M. E.; Gray, M. D.; Sanchez Gaytan, J. N.; Enstrom, M. R.; Linton, J. D.; Rongvaux, A.; Taylor, J. J.; Adair, J. E.

10.1101/2025.05.02.651933 — immunology — Posted on 2025-05-08

4559 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy

Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.

10.1101/2024.10.28.618752 — neuroscience — Posted on 2025-05-08

4560 A multilayer network approach elucidates time- and tissue-specific developmental and aging processes

Lombardo, S. D.; Rendeiro, A. F.; Menche, J.

10.1101/2025.05.02.651926 — systems biology — Posted on 2025-05-08

4561 WITHDRAWN: Oncostratifier: Stratifying Oncogene-addicted Cohorts By Drug Response

Tepeli, Y. I.; Trastulla, L.; Goncalves, J. P.; Iorio, F.

10.1101/2025.05.01.650955 — cancer biology — Posted on 2025-05-08

4562 A Toolbox for the Personalization of Plasmonic Photothermal Therapy in Orthotopic Mouse Tumor Models

Fernandez Esteberena, P. R.; Vilches, C.; Morales-Dalmau, J.; Mireles, M.; Martinez-Lozano, M. d. M.; de Miguel, I.; Casanovas, O.; Quidant, R.; Durduran, T.

10.1101/2025.05.02.651947 — biophysics — Posted on 2025-05-08

4563 Unifying Orientation-Dependent Relaxation and Diffusion Around Axonal Fibers from DTI: Characterizing Fiber-Tract-Specific Anisotropic R2 Profiles of the Corpus Callosum

Pang, Y.; Raja, R.; Reddick, W. E.

10.1101/2025.05.02.651936 — biophysics — Posted on 2025-05-08

4564 ORANGE: A Machine Learning Approach for Modeling Tissue-Specific Aging from Transcriptomic Data

Jalal, W.; Musarrat, M.; Samee, M. A. H.; Rahman, M. S.

10.1101/2025.05.02.651895 — bioinformatics — Posted on 2025-05-08

4565 NeuroMark-HiFi: A Data-Driven Method for Detecting High-Spatial-Frequency Functional Brain Networks

Behzadfar, N.; Iraji, A.; Calhoun, V.

10.1101/2025.05.02.651877 — bioengineering — Posted on 2025-05-08

4566 Respiratory synchrony and individual differences causally influence dyadic interpersonal coordination

YI, W.; Palmer, C.

10.1101/2025.05.02.651958 — animal behavior and cognition — Posted on 2025-05-08

4567 Cryptic diversity arises from glacial cycles in Pacific herring, a critical forage fish

Timm, L. E.; Almgren, S. A.; Lopez, J. A.; Glass, J. R.

10.1101/2025.05.02.651951 — genomics — Posted on 2025-05-08

4568 Landscape genomics and demography of California Azolla

Song, M. J.; Tribble, C. M.; Gonzalez-Ramirez, I.; Freund, F.; Li, F.-W.; Rothfels, C. J.

10.1101/2025.05.02.651959 — ecology — Posted on 2025-05-08

4569 FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi

Bedard, C.; Pageau, A.; Fijarczyk, A.; Mendoza-Salido, D.; Alcaniz, A.; Despres, P.; Durand, R.; Plante, S.; Alexander, E.; Rouleau, F.; Jordan, D. F.; Jay, A.; Giguere, M.; Bernier, M.; Sharma, J.; Maroc, L.; Gervais, N.; Menon, A.; Gagnon-Arsenault, I.; Bakker, S.; Rhodes, J.; Dufresne, P.; Bharat, A.; Sellam, A.; De Luca, D.; Gerstein, A.; Shapiro, R.; Quijada, N.; Landry, C.

10.1101/2024.10.07.617009 — microbiology — Posted on 2025-05-08

4570 A biofilm-tropic Pseudomonas aeruginosa bacteriophage uses the exopolysaccharide Psl as receptor

Walton, B.; Abbodante, S.; Marshall, M. E.; Dobruchowska, J. M.; Alvi, A.; Gallagher, L. A.; Vallikat, N.; Zhang, Z.; Wozniak, D. J.; Yu, E. W.; Boons, G.-J.; Pearlman, E.; Rietsch, A.

10.1101/2024.08.12.607380 — microbiology — Posted on 2025-05-08

4571 An enteric neuron-expressed variant ionotropic receptor detects ingested salts to regulate salt stress resistance

Yeon, J.; Chen, L.; Krishnan, N.; Bates, S.; Porwal, C.; Sengupta, P.

10.1101/2025.04.11.648259 — neuroscience — Posted on 2025-05-08

4572 Short-Term Exposure to Polystyrene Microplastics Alters Cognition, Immune, and Metabolic Markers in an APOE Genotype and Sex-Dependent Manner

Gaspar, L.; Bartman, S.; Tobias-Wallingford, H.; Coppotelli, G.; Ross, J. M.

10.1101/2025.05.02.651942 — neuroscience — Posted on 2025-05-08

4573 Correlates of head-fixed orienting movements in mouse superior colliculus and substantia nigra pars reticulata

Doykos, T. K.; Yamauchi, T.; Buteau, A.; Hanson, S.; Dudman, J. T.; Felsen, G. K.; Stubblefield, E. A.

10.1101/2025.05.02.651955 — neuroscience — Posted on 2025-05-08

4574 Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer

Llevenes, P.; Chen, A.; Lawton, M. L.; Rondon-Ortiz, A. N.; Qiu, Y.; Seen, M.; Monti, S.; Denis, G. V.

10.1101/2024.10.10.617639 — cancer biology — Posted on 2025-05-08

4575 Not All Saliva Samples Are Equal: The Role of Cellular Heterogeneity in DNA methylation and Epigenetic Age Analyses with Biological and Psychosocial Factors

Chan, M. H.-M.; Meijer, M.; Merrill, S. M.; Fu, M. P. Y.; Lin, D.; MacIsaac, J. L.; Riis, J. L.; Granger, D. A.; Thomas, E. A.; Kobor, M. S.

10.1101/2024.11.08.621377 — bioinformatics — Posted on 2025-05-08

4576 Long-term effects of an elephant-dominated browser community on the architecture of trees in a fenced reserve

Thel, L.; Stols, D.; Orth, S.; Lagendijk, D. D. G.; Slotow, R.; Venter, J. A.; Fritz, H.

10.1101/2024.12.18.629108 — ecology — Posted on 2025-05-08

4577 GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells

Deng, C.; Elujoba-Bridenstine, A.; Song, A. T.; Ceplina, R. M.; Ostheimer, C. J.; Hahn, M. C. P.; Scarlett, C. O.; Tamplin, O. J.

10.1101/2025.04.30.651482 — cell biology — Posted on 2025-05-08

4578 Using Beads as a Focus Fiduciary to Aid Software-based Autofocus Accuracy in Microscopy

Gibson, I.; Osterlund, E. J.; Truant, R.

10.1101/2025.03.18.643916 — cell biology — Posted on 2025-05-08

4579 Long-term Culturing of Pseudomonas aeruginosa in Static, Minimal Nutrient Medium Results in Increased Pyocyanin Production, Reduced Biofilm Production, and Loss of Motility

Cecil, R. E.; Ornelas, E.; Phan, A.; Medina-Chavez, N. O.; Travisano, M.; Yoder-Himes, D. R.

10.1101/2024.02.26.582132 — microbiology — Posted on 2025-05-08

4580 Discovery of giant viruses as past and present infections of zoosporic fungi

Myers, J.; Schulz, F.; Rahimlou, S.; Yadav, V.; Amses, K.; Simmons, D. R.; Sun, S.; Orozco-Quime, M.; Heitman, J.; Stajich, J. E.; James, T.

10.1101/2024.01.04.574182 — microbiology — Posted on 2025-05-08

4581 ALIGaToR: A tool for the automated annotation of immunoglobulin and T cell receptor genomic loci

Schramm, C. A.; Olubo, S.; Douek, D. C.

10.1101/2025.05.02.651960 — immunology — Posted on 2025-05-08

4582 Individualized AI-driven neuromodulation enhances tongue motor and sensory control: preliminary efficacy targeted towards the alleviation of chronic cranial neuropathies

Papageorgiou, T. D.; Webb, J.; Allam, A.; Froudarakis, E.; Rohren, E. M.; Sturgis, E. M.; Hutcheson, K. A.; Heilbronner, S. R.

10.1101/2025.04.30.651533 — neuroscience — Posted on 2025-05-08

4583 Humans adapt rationally to approximate estimates of uncertainty

Pulcu, E.; Browning, M.

10.1101/2023.11.26.568699 — neuroscience — Posted on 2025-05-08

4584 Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration

Jiang, Y.; Sachdeva, K.; Goulbourne, C. N.; Berg, M. J.; Peddy, J.; Stavrides, P. H.; Pensalfini, A.; Pawlik, M.; Malapati, S.; Whyte, L. S.; Basavaraj, B. S.; Shivakumar, S.; Bleiwas, C.; Smiley, J. F.; Mathews, P. M.; Nixon, R. A.

10.1101/2024.09.19.613736 — neuroscience — Posted on 2025-05-08

4585 The Thermal Grill Elicits Central Sensitization

Cormie, M. A.; Seminowicz, D. A.; Moayedi, M.

10.1101/2025.02.12.637900 — neuroscience — Posted on 2025-05-08

4586 Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

Murano, T.; Hagihara, H.; Tajinda, K.; Takao, K.; Takamiya, Y.; Katoh, K.; Robison, A. J.; Matsumoto, M.; Namihira, M.; Miyakawa, T.

10.1101/2025.05.02.651848 — neuroscience — Posted on 2025-05-08

4587 Challenges in inferring breathing rhythms from olfactory bulb local field potentials

Rafilson, S. E.; Hess, N.; Findley, T. M.; Smear, M.

10.1101/2024.11.08.622727 — neuroscience — Posted on 2025-05-08

4588 Neurospectrum: A Geometric and Topological Deep Learning Framework for Uncovering Spatiotemporal Signatures in Neural Activity

Bhaskar, D.; Zhang, Y.; Moore, J. L.; Gao, F.; Rieck, B.; Wolf, G.; Khasawneh, F.; Munch, E.; Noah, J. A.; Pushkarskaya, H.; Pittenger, C.; Greco, V.; Krishnaswamy, S.

10.1101/2023.03.22.533807 — neuroscience — Posted on 2025-05-08

4589 Mature neutrophils promote long-term functional recovery after spinal cord injury in a sex-dependent manner

Pacheco, M. R.; Tran, A. V.; Bradley, M.; Leal-Garcia, M. E.; Ozturgut, M.; Barnett, E. A.; Chakka, V.; Devaraj, S.; Kirchhoff, M.; Mulamba, T.; Thomas, K.; Vu, N. V.; McCreedy, D.

10.1101/2025.02.25.640256 — neuroscience — Posted on 2025-05-08

4590 STREAMLINING HISTOPATHOLOGY: INSTAPRESERVE TISSUESAFE A SINGLE-STEP FIXATIVE THAT IMPROVES TISSUE QUALITY AND WORKFLOW EFFICIENCY

Vangala, R. K.; Vangala, A. B.; Kanukollu, S.; Sankarnarayanan, P. M.; Shankar, A.; Murugaian, E. E.

10.1101/2025.05.01.651707 — pathology — Posted on 2025-05-08

4591 How monitoring behavior can inform conservation? The case of Spix's macaws under human care

Marcuk, V.; Purchase, C.; Scholtyssek, K.; Amador, J.; Crosta, L.; Crosta, P.-S.; Gupta, B. K.; Hofer, H.; Courtiol, A.

10.1101/2025.05.02.651864 — animal behavior and cognition — Posted on 2025-05-08

4592 WITHDRAWN: Codon-Optimized Base Editors Enable Efficient Base Substitution in Non-model Animals

Wang, J.

10.1101/2025.04.25.650635 — genetics — Posted on 2025-05-08

4593 WITHDRAWN: Triple gene disruption confers genetic resistance to infectious salmon anaemia virus in Atlantic salmon (Salmo salar)

Wang, J.

10.1101/2025.04.25.650625 — genetics — Posted on 2025-05-08

4594 Fire limits soil microbial dispersal and differentially impacts bacterial and fungal communities

Hopkins, J. R.; Vizzari, G.; Bennett, A. E.; Malacrino, A.

10.1101/2025.05.02.651892 — ecology — Posted on 2025-05-08

4595 Plant functional groups and root traits are linked to exudation rates of mature temperate trees

Oh, Y. E.; Midgley, M. G.; McCormack, M. L.; Beidler, K. V.; McCall, M.; Henderson, S.; Braghiere, R. K.; Phillips, R. P.

10.1101/2024.08.01.606171 — ecology — Posted on 2025-05-08

4596 FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans

Bhat, U. S.; Surendran, S.; H, S.; Liu, J.; Xu, Y.; Tasnim, N.; Bhardwaj, A.; Scholz, M.; Babu, K.

10.1101/2025.05.02.651881 — neuroscience — Posted on 2025-05-08

4597 iCSD can produce spurious results in dense electrode arrays

Tharayil, J. J.; Neufeld, E.; Reimann, M.

10.1101/2025.05.02.651822 — neuroscience — Posted on 2025-05-08

4598 Warm and cool temperatures decrease early-life telomere length in wild pied flycatchers

Furic, C.; Marciau, C.; Hsu, B.-Y.; Cossin-Sevrin, N.; Fleitz, J.; Reichert, S.; Ruuskanen, S.; STIER, A.

10.1101/2025.05.02.651824 — zoology — Posted on 2025-05-08

4599 Predicting Molecular Taste: Multi-Label and Multi-Class Classification

Ramanathan, V.; DN, S. S.

10.1101/2025.05.02.651828 — bioinformatics — Posted on 2025-05-08

4600 INLAomics for Scalable and Interpretable Spatial Multiomic Data Integration

Arnroth, L.; Vickovic, S.

10.1101/2025.05.02.651831 — bioinformatics — Posted on 2025-05-08

4601 Observation of tandem running behavior in mating pairs of Asian dampwood termite, Hodotermopsis sjostedti

Mizumoto, N.; Chambliss, W.; Carroll, E.; Nakazono, T.; Kanao, T.

10.1101/2025.05.02.651862 — animal behavior and cognition — Posted on 2025-05-08

4602 Emergent epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure

Guillemet, M.; Lehtinen, S.

10.1101/2025.05.02.651819 — evolutionary biology — Posted on 2025-05-08

4603 Single molecule imaging of transcription dynamics, RNA localization and fate in T cells

Lattanzio, M. V.; Sostaric, N.; Kanagasabesan, N.; Popovic, B.; Bradaric, A.; Wardak, L.; Guislain, A.; Savakis, P. E.; Tutucci, E.; Wolkers, M. C.

10.1101/2024.11.11.622939 — immunology — Posted on 2025-05-08

4604 Lymphocytes and monocytes undergo swift suppression of IL-10R, IL-6R, and IL-2Rβγ signaling under high concentrations of different cytokines

Kuznetsov, M.; Rodrigues Lima Junior, J.; Rockne, R. C.; Branciamore, S.; Rodin, A. S.; Lee, P. P.

10.1101/2025.05.02.651967 — immunology — Posted on 2025-05-08

4605 NKp46 Recognizes the Hyphal Form of Candida albicans and Mediates Protective Antifungal Immunity

Liu, M.; Rishiq, A.; Charpak-Amikam, Y.; Li, F.; Mandelboim, O.

10.1101/2025.05.02.651874 — immunology — Posted on 2025-05-08

4606 Repositioning of polyubiquitin alters the pathologic tau filament structure

Watanabe, R.; Creekmore, B. C.; Darwich, N. F.; Xu, H.; Changolkar, L.; Hoxha, K.; Zhang, B.; O'Rourke, C. M.; Burslem, G. M.; Lee, V. M.-Y.; Chang, Y.-W.; Lee, E. B.

10.1101/2025.05.02.651930 — neuroscience — Posted on 2025-05-08

4607 ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

Gomez Deza, J.; Nebiyou, M.; El Touny, L. H.; Alkaslasi, M. R.; Zuo, Z.; Wlaschin, J. J.; Nadal-Nicolas, F. M.; Slavutsky, A. L.; Lloyd, E. Y.; Hayashi, P. M.; Ashby, N.; Sohn, M.; Dale, R.; Li, W.; Cheng, K.; Rocha, P.; Le Pichon, C. E.

10.1101/2023.09.27.559856 — neuroscience — Posted on 2025-05-08

4608 Regulation of Transcriptional Bursting and Spatial Patterning in Early Drosophila Embryo Development

Nieto, C.; Vahdat, Z.; Lim, B.; Singh, A.

10.1101/2025.05.02.651973 — systems biology — Posted on 2025-05-08

4609 Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers

Ahn, C.; Zhang, T.; Rode, T.; Yang, G.; Chugh, O. K.; Ellis, S.; Ghayur, S. J.; Mehta, S.; Salzman, R.; Jiang, H.; Parker, S.; Burant, C.; Horowitz, J. F.

10.1101/2025.05.02.651890 — physiology — Posted on 2025-05-08

4610 Early onset of Ca2+ waves and synchronization in multicellular clusters facilitate focal arrhythmogenesis in human heart failure

Kazakova, D.; Colman, M.; Pradhan, A.; Gudaitis, L.; Nys, L.; Cools, B.; Rega, F.; Vandenberk, B.; Terracciano, C. M.; Roderick, L.; Sipido, K.; Dries, E.

10.1101/2025.05.02.651991 — physiology — Posted on 2025-05-08

4611 A physiology-based mathematical model of the renin-angiotensin system, bone remodeling, and calcium homeostasis: Effects of estrogen and renin-angiotensin system inhibitors

Stadt, M.; Layton, A. T.

10.1101/2025.05.01.651663 — physiology — Posted on 2025-05-08

4612 Advanced Cardiac Organoid Model for Studying Doxorubicin-Induced Cardiotoxicity

Wu, X.; Williams, S.; Robidoux, J.; Sriramula, S.; Abdel, A.-R.

10.1101/2025.05.02.651878 — pharmacology and toxicology — Posted on 2025-05-08

4613 High-Throughput Evaluation of Cryoprotective Agents for Mixture Effects That Reduce Toxicity

Ahmadkhani, N.; Sugden, C.; Benson, J. D.; Eroglu, A.; Higgins, A. Z.

10.1101/2025.05.02.651925 — pharmacology and toxicology — Posted on 2025-05-08

4614 Age-Dependent, Odorant-Specific Changes in Olfactory Sensitivity in an Alzheimer's Disease Mouse Model

Adachi, Y.; Katori, K.; Ishiyama, S.; Morikawa, S.; Saito, T.; Saido, T. C.; Ikegaya, Y.; Takeuchi, H.

10.1101/2025.05.02.651821 — pathology — Posted on 2025-05-08

4615 Loss of ATG5 expression in a subset of human prostate cancers promotes tumor growth through accumulation of p62

Wible, D. J.; Li, W.; Liu, X.; Sebastian, M. M.; Tang, D. G.; Bratton, S. B.

10.1101/2025.05.02.651776 — cancer biology — Posted on 2025-05-08

4616 Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer

Wu, J.; Lai, Y.; Li, J.; Zhai, L.; Asthana, P.; Chen, L.; Chen, M.; Chen, B.; Gurung, S.; Lyu, J.; Zhang, Y.; Lin, L.; Huang, S.; Kuang, W.; Shi, H.; Luo, Y.; Kong, X.; Wong, S. H.; Chan, K. M.; Yuan, S.; Kwan, H. Y.; Yuan, X.; Huang, W.; Ruan, Y.; Lu, H.; Wong, C. C.; Lyu, A.; Bian, Z.; Ren, Y.; Wu, X.; Ma, Y.; Wong, H. L. X.

10.1101/2025.05.02.651972 — cancer biology — Posted on 2025-05-08

4617 Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909

Laughlin, Z. T.; Arifova, L.; Munoz-Tello, P.; Yu, X.; Karadi Giridhar, M. N.; Dong, J.; Harp, J. M.; Zu, D.; Kamenecka, T. M.; Kojetin, D. J.

10.1101/2025.05.04.651770 — biophysics — Posted on 2025-05-08

4618 FlashFold: a standalone command-line tool for accelerated protein structure and stoichiometry prediction

Saha, C. K.; Roghanian, M.; Häussler, S.; Guy, L.

10.1101/2025.01.23.634437 — bioinformatics — Posted on 2025-05-08

4619 Surforama: interactive exploration of volumetric data by leveraging 3D surfaces

Yamauchi, K. A.; Lamm, L.; Gaifas, L.; Righetto, R. D.; Litvinov, D.; Engel, B. D.; Harrington, K.

10.1101/2024.05.30.596601 — bioinformatics — Posted on 2025-05-08

4620 Functional alignment of protein language models via reinforcement learning

Blalock, N.; Seshadri, S.; Babbar, A.; Fahlberg, S. A.; Kulkarni, A.; Romero, P. A.

10.1101/2025.05.02.651993 — bioengineering — Posted on 2025-05-08

4621 GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner

Löbbert, A.; Lorz, N.; Matthees, E. S. F.; Rössler, P.; Hoffmann, C.; Gossert, A. D.

10.1101/2025.05.06.652336 — biochemistry — Posted on 2025-05-08

4622 Septin7 is essential in early hematopoiesis, but redundant at later stages

Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.

10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-05-08

4623 Using single-cell genomics to explore transcriptional divergence and cis-regulatory dynamics of duplicated genes

Li, X.; Zhang, X.; Schmitz, R. J.

10.1101/2025.05.07.652760 — evolutionary biology — Posted on 2025-05-08

4624 Performance evaluation of adaptive introgression classification methods

Romieu, J.; Camarata, G.; Crochet, P.-A.; de Navascues, M.; Leblois, R.; Rousset, F.

10.1101/2024.06.12.598278 — evolutionary biology — Posted on 2025-05-08

4625 Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome

Tsai, W.-C.; Peng, P.; Jhou, P.-S.; Tsai, Y.-C.; Hung, W.-W.; Lin, Y.-H.; Jhuo, S.-J.; Huang, T.-C.; Chou, L.-F.; LIN, T.-H.; Su, H.-M.; Lai, W.-T.; Lee, C.-H.; Wu, B.-N.; Lin, S.-F.; Hung, W.-C.

10.1101/2025.05.06.652555 — microbiology — Posted on 2025-05-08

4626 Preconditioning Matters: Enhancing or Impairing Antitumor Immunity with DC Vaccines

Kwon, E.; Namen, S.; Willoughby, C. J.; Kang, S.; Pandey, G.; Kim, A. B.; DeSelm, C. J.

10.1101/2025.05.02.651990 — immunology — Posted on 2025-05-08

4627 Seizure-induced Transient Disruptive Changes in Brain Microstructure

Takamiya, A.; Riemer, F.; Erchinger, V. J.; Korbmacher, M.; Bartsch, H.; Ousdal, O. T.; Maximov, I.; Dale, A.; Emsell, L.; Oedegaard, K. J.; Kessler, U.; Oltedal, L.

10.1101/2025.05.05.652221 — neuroscience — Posted on 2025-05-08

4628 Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

Murano, T.; Hagihara, H.; Tajinda, K.; Takao, K.; Takamiya, Y.; Katoh, K.; Robison, A. J.; Matsumoto, M.; Namihira, M.; Miyakawa, T.

10.1101/2025.05.02.651848 — neuroscience — Posted on 2025-05-08

4629 Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms

Gomes, C.; Huang, K.-C.; Lavekar, S. S.; Harkin, J.; Prosser, C. G.; Fang, Y.; Kallem, C.; Oblak, A.; Zhang, C.; Meyer, J. S.

10.1101/2025.05.02.651934 — neuroscience — Posted on 2025-05-08

4630 A ubiquitous spectrolaminar motif across independent studies, including in the Mackey et al. dataset

Major, A. J.; Abdaltawab, A.; Phillips, J. M.; Wang, T.; Lee, E. K.; Lichtenfeld, M. J.; Chandrasekaran, C.; Saalmann, Y. B.; Maier, A.; Desimone, R.; Miller, E. K.; Bastos, A. M.; Mendoza-Halliday, D.

10.1101/2025.05.07.652644 — neuroscience — Posted on 2025-05-08

4631 Light of both high and low melanopic illuminance have positive effects on attention and alertness

Bjerrum, L. B.; Visted, E.; Nordhus, I. H.; Osnes, B.; Bjorvatn, B.; Bugge Kambestad, O.; Hansen, M. E.; Sorensen, L.; Flo-Groeneboom, E.

10.1101/2025.01.15.633100 — neuroscience — Posted on 2025-05-08

4632 Neural rhythms as priors of speech computations

Chandravadia, N.; Imam, N.

10.1101/2025.05.06.652542 — neuroscience — Posted on 2025-05-08

4633 A hierarchical cascade of sleep rhythms drive memory consolidation in humans and are disrupted in epilepsy.

Wodeyar, A.; Chinappen, D.; Kwon, H.; Shi, W.; Richardson, M.; Kramer, M. A.; Chu, C. J.

10.1101/2025.05.06.652436 — neuroscience — Posted on 2025-05-08

4634 Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution

Haque, R.; Setty, H.; Lorenzo, R.; Stelzer, G.; Rotkopf, R.; Salzberg, Y.; Kumar, S.; Goldman, G.; Nir Halber, S.; Schneidman, E.; Leifer, A. M.; Laurent, P.; Oren-Suissa, M.

10.1101/2024.12.27.630541 — neuroscience — Posted on 2025-05-08

4635 The Arabidopsis WAVE/SCAR Protein BRICK1 Associates with Cell Edges and Plasmodesmata

Ambrose, C.; Chi, Z.

10.1101/2025.05.06.652582 — plant biology — Posted on 2025-05-08

4636 Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse

Medrano, S.; Almeida, L.; Ruiz-Perez, F.; Gutierrez-Hernandez, A.; Yamaguchi, H.; Matsuoka, D. M.; Yamaguchi, M.; Smith, J. P.; Wagamon, T.; Sequeira-Lopez, M.; Gomez, R. A.

10.1101/2025.05.02.651896 — physiology — Posted on 2025-05-08

4637 Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

Qiu, H.; Yue, X.; Huang, Y.; Meng, Z.; Wang, J.; Qiao, D.

10.1101/2025.05.02.651823 — pharmacology and toxicology — Posted on 2025-05-08

4638 Topology, Kinetics and Inheritance in Clonal Colonies of Bone Marrow Stromal Cells

Allegrezza, A.; Beschi, R.; Caudo, D.; Cavagna, A.; Corsi, A.; Culla, A.; Donsante, S.; Giannicola, G.; Giardina, I.; Gosti, G.; Grigera, T. S.; Melillo, S.; Palmisano, B.; Parisi, L.; Postiglione, L.; Riminucci, M.; Rotondi, F. S.

10.1101/2025.05.02.651830 — biophysics — Posted on 2025-05-08

4639 GeneFix-AI: AI-Powered CRISPR-Cas9 System for Real-Time Detection and Correction of Mutations in Non-Human Species

Ali, M.

10.1101/2025.05.04.652132 — bioinformatics — Posted on 2025-05-08

4640 AI-powered integration of multi-source data for TAA discovery to accelerate ADC and TCE drug development (I): TAA Target Identification and Prioritization

Xie, T.; Huang, C.-H.

10.1101/2025.05.06.652559 — bioinformatics — Posted on 2025-05-08

4641 Identification of a novel transcriptome signature for predicting the response to anti-TNF-α treatment in rheumatoid arthritis patients

Pena, R. D.

10.1101/2025.05.05.652166 — genomics — Posted on 2025-05-08

4642 Patterns of Aedes aegypti immature ecology and arboviral epidemic risks in peri-urban and intra-urban villages of Cocody-Bingerville, Cote d'Ivoire: insights from a dengue outbreak

Bire, Y. N.; Zahouli, J. Z. B.; Dibo, J. D. K.; Coulibaly, P. N.; Manouana, P. G.; Mavoungou, J. F.; Hellhammer, F.; Maganga, G. D.; Djogbenou, L. S.; Adegnika, A. A.; Borrmann, S.; Becker, S. C.; Toure, M.

10.1101/2025.05.05.652274 — ecology — Posted on 2025-05-08

4643 Venomous Maggots? A first exploration of the toxin arsenal of larval stages of the horse fly Tabanus autumnalis

Kraemer, J.; Dersch, L.; Vilcinskas, A.; Lueddecke, T.

10.1101/2025.05.06.652366 — molecular biology — Posted on 2025-05-08

4644 Modeling Dyslexia in Neurotypical Adults by Combining Neuroimaging and Neuromodulation Techniques: A Hypothesis Paper

Gallagher, D.; Huang, Z.; Ohta, S.

10.1101/2025.05.04.651804 — neuroscience — Posted on 2025-05-08

4645 Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders

Giacomel, A.; Powell, T. R.; Duarte, R. R.; Nordio, G.; Williams, S. C. R.; Turkheimer, F. E.; Veronese, M.; Martins, D.; Dima, D.

10.1101/2025.05.06.652361 — neuroscience — Posted on 2025-05-08

4646 Nutritional Ketosis Attenuates Sucrose Bingeing-Induced Behavioral Deficits by Improving Synaptic Plasticity and Anti-Inflammatory Signalling in the Prefrontal Cortex of Male and Female Mice

Gusain, C.; Kumar, M.

10.1101/2025.05.07.651641 — neuroscience — Posted on 2025-05-08

4647 Neuromodulation of risk preferences encoded in human orbitofrontal cortex activity

Skular, A.; Lu, J.; Overton, J.; Saez, I.

10.1101/2025.05.06.650317 — neuroscience — Posted on 2025-05-08

4648 The Association Between SLIT2 in Human Vitreous Humor and Plasma and Neurocognitive Test Scores

Shoushtari, S. I.; Liaw, E.; Alluri, S.; Sheikh, Z.; Kumar, S.; Huynh, C.; Schmidt, I. M.; Ness, S.; Chen, X.; Siegel, N. H.; Waikar, S. S.; Stein, T. D.; Lu, W.; Subramanian, M. L.

10.1101/2025.05.03.652072 — neuroscience — Posted on 2025-05-08

4649 Altered perceptual integration and learning in autism revealed by games inspired by rodent operant tasks

Chakravarty, S.; Do, Q.; Li, Y.; Tager-Flusberg, H.; McGuire, J. T.; Scott, B. B.

10.1101/2025.05.06.652509 — neuroscience — Posted on 2025-05-08

4650 G3BP1 Phosphorylation Regulates Plant Immunity in Arabidopsis

Hirt, H.; Abdulhakim, F.; Abdulfaraj, A.; Rayapuram, N.

10.1101/2025.05.06.652493 — plant biology — Posted on 2025-05-08

4651 Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added In Silico Predictions

Fagerholm, U.

10.1101/2025.05.05.652242 — pharmacology and toxicology — Posted on 2025-05-08

4652 Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Dreute, J.; Stengel, J.; Becher, J.; van den Borre, D. R.; Pfisterer, M.; Bartkuhn, M.; Beutgen, V. M.; Ndreshkjana, B.; Gaertner, U.; Graumann, J.; Huck, M.; Klatt, S.; Leff, C. L.; Farin, H. F.; Nist, A.; Schmitz, R.; Stiewe, T.; Teply-Szymanski, J.; Wilhelm, J.; Cabrera-Orefice, A.; Schmitz, M. L.

10.1101/2025.05.02.651820 — cancer biology — Posted on 2025-05-08

4653 gorder: Comprehensive tool for calculating lipid orderparameters from molecular simulations

Bartos, L.; Pajtinka, P.; Vacha, R.

10.1101/2025.05.07.652627 — biophysics — Posted on 2025-05-08

4654 A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region

Li, R. Y.; Su, C.; Qin, Z. S.

10.1101/2025.05.06.652558 — bioinformatics — Posted on 2025-05-08

4655 A ribozyme ligase that requires a 3' terminal phosphate on its RNA substrate

Biswas, A.; Weiss, Z.; Szostak, J. W.; DasGupta, S.

10.1101/2025.05.06.652512 — biochemistry — Posted on 2025-05-08

4656 Male mice prefer to live on their own

Davies, J.; Jackson, M. G.; Hinchcliffe, J. K.; Mendl, M.; Robinson, E. S. J.

10.1101/2025.05.02.651815 — animal behavior and cognition — Posted on 2025-05-08

4657 Novel artificial selection method improves function of simulated microbial communities

Vessman, B.; Guridi-Fernandez, P.; Arias-Sanchez, F. I.; Mitri, S.

10.1101/2023.01.08.523165 — evolutionary biology — Posted on 2025-05-08

4658 Characterisation of cell cycle checkpoint kinases in Toxoplasma gondii

Johnson, M. K.; Chelaghma, S.; Lewis, W. H.; Koreny, L.; Waller, R. F.; Merrick, C. J.

10.1101/2024.09.10.612042 — microbiology — Posted on 2025-05-08

4659 Divisive attenuation based on noisy sensorimotor predictions accounts for excess variability in self-touch

Vale, N.; Tomic, I.; Girones, Z.; Wolpert, D. M.; Kilteni, K.; Bays, P.

10.1101/2024.06.20.599826 — neuroscience — Posted on 2025-05-08

4660 A chance insight into phosgene toxicity

Daplan, E.; Rodriguez, E.; Lane, N.; Turin, L.

10.1101/2024.04.23.590734 — pharmacology and toxicology — Posted on 2025-05-08

4661 ALS mutations disrupt self-association between the Ubiquilin Sti1 hydrophobic groove and internal placeholder sequences

Onwunma, J.; Binsabaan, S.; Allen, S. P.; Sankaran, B.; Wohlever, M. L.

10.1101/2024.07.10.602902 — biochemistry — Posted on 2025-05-08

4662 Experiencing the wild: Red fox encounters are related to stronger nature connectedness, not anxiety, in people

Morton, B.; Soulsbury, C. D.

10.1101/2025.03.25.645298 — animal behavior and cognition — Posted on 2025-05-08

4663 Priority Effects Can Shape Strain-Level Community Assembly and Function in a Bioluminescent Symbiosis

Roman, E. D.; Nebhut, A. N.; Fukami, T.; Gould, A. L.

10.1101/2025.05.01.651688 — ecology — Posted on 2025-05-08

4664 Brain bases for navigating acoustic features

Billig, A. J.; Sedley, W.; Gander, P. E.; Kumar, S.; Lad, M. J.; Chait, M.; Mohammadi, Y.; Berger, J. I.; Griffiths, T.

10.1101/2025.02.10.636597 — neuroscience — Posted on 2025-05-08

4665 Interplay between MIG-6/papilin and TGF-β signaling promotes extracellular matrix remodeling and modulates the maintenance of neuronal architecture

Benard, C. Y.; Nadour, M.; VALETTE R. L., R. I.; FREBAULT, N.; Fontaine, V.; Rivollet, L.

10.1101/2025.05.08.652809 — genetics — Posted on 2025-05-08

4666 SeQuoIA: a single-cell BCR sequencing analysis pipeline for tracking selection mechanisms in germinal centres

Hector, E.; Milpied, P.

10.1101/2025.02.13.638132 — immunology — Posted on 2025-05-08

4667 Stretch and flow at the gliovascular interface: high-fidelity modelling of the mechanics of astrocyte endfeet

Causemann, M.; Enger, R.; Rognes, M. E.

10.1101/2025.05.08.652799 — neuroscience — Posted on 2025-05-08

4668 Scale-dependent brain age with higher-order statistics from structural magnetic resonance imaging

Carnero-Rosell, A.; Janssen, N.; Maselli, A.; Pereda, E.; Huertas-Company, M.; Kitaura, F.-S.

10.1101/2025.03.24.644902 — neuroscience — Posted on 2025-05-08

4669 Virtual Colon: Spatiotemporal modelling of metabolic interactions in a computational colonic environment

Marinos, G.; Zimmermann, J.; Taubenheim, J.; Kaleta, C.

10.1101/2024.06.11.598488 — systems biology — Posted on 2025-05-08

4670 Using single-cell genomics to explore transcriptional divergence and cis-regulatory dynamics of duplicated genes

Li, X.; Schmitz, R. J.; Zhang, X.

10.1101/2025.05.07.652760 — evolutionary biology — Posted on 2025-05-08

4671 Competing regulatory modules control the transition between mammalian gastrulation modes

Wehmeyer, A. E.; Schmitt, J. K.; Eggersdorfer, F.; Zissel, L.; Schröder, C. M.; Dias, A.; Schüle, K. M.; Probst, S.; Arias, A. M.; McDole, K.; Arnold, S. J.

10.1101/2025.05.07.652670 — developmental biology — Posted on 2025-05-08

4672 Developmental landscape of shark telencephalon sheds light on the evolution of telencephalic cell types and the ancient origin of Cajal-Retzius cells

Quintana-Urzainqui, I.; Oel, P.; Berger, T.; Pan, L.; Papadopoulos, N.; Serka, G.; Verbanac, A.; Boersig, M.; Torres-Sabino, D.; Rollan-Delgado, I. C.; Santangeli, L.; Kaessmann, H.; Arendt, D.

10.1101/2025.05.08.652169 — developmental biology — Posted on 2025-05-08

4673 Floral Stage Optimization and Immune Evasion Enhance Agrobacterium-Mediated Genome Editing in Arabidopsis

Liu, M.-S.; Huang, T.-K.; Wang, Y.-C.; Wang, S.-C.; WU, C.-H.; Kuo, C.-H.; Lai, E.-M.

10.1101/2025.05.07.652770 — plant biology — Posted on 2025-05-08

4674 Tracing the Spread of Celtic Languages using Ancient Genomics

McColl, H.; Kroonen, G.; Pinotti, T.; Barrie, W.; Koch, J.; Ling, J.; Demoule, J.-P.; Kristiansen, K.; Sikora, M.; Willerslev, E.

10.1101/2025.02.28.640770 — evolutionary biology — Posted on 2025-05-08

4675 PU.1 and TGF-β signaling transactivate CD103 expression in mast cells and dendritic cells: Opposite roles of GATA2 in the expression of mucosal mast cell-specific genes

Ishii, K.; Nagata, K.; Yamashita, N.; Yamazaki, Y.; Akimoto, Y.; Zhao, W.; Inoue, M.; Ito, N.; Kasakura, K.; Nishiyama, C.

10.1101/2025.02.10.637371 — molecular biology — Posted on 2025-05-08

4676 Selective control of prefrontal neural timescales by parietal cortex

Soyuhos, O.; Zirnsak, M.; Moore, T.; Chaudhuri, R.; Chen, X.

10.1101/2024.09.30.615928 — neuroscience — Posted on 2025-05-08

4677 Somatosensory high frequency oscillations across the human central nervous system

Bailey, E.; Nierula, B.; Stephani, T.; Waterstraat, G.; Curio, G.; Nikulin, V.; Eippert, F.

10.1101/2024.11.16.622608 — neuroscience — Posted on 2025-05-08

4678 Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.

Bond, D. R.; Burnard, S. M.; Uddipto, K.; Hunt, K. V.; Harvey, B. M.; Steffens Reinhardt, L.; Lawlor-O'Neill, C.; Roper, E. A.; Humphries, S.; Murray, H. C.; Mannan, A.; Dun, M. D.; de Bock, C.; Bowden, N. A.; Enjeti, A. K.; Verrills, N. M.; Riveros, C.; Le Cao, K.-A.; Lee, H. J.

10.1101/2024.01.30.577864 — cancer biology — Posted on 2025-05-08

4679 Macromolecular Crowding-Affected Mobility of Bcnt/Cfdp1, a Disordered Component of the Srcap Complex, from the Nucleus to Cytosol in Subcellular Fractionation

Iwashita, S.; Suzuki, T.; Nishimura, K.; Onishi, A.; Tsukuda, K.; Kakihara, Y.; Kiriyama, Y.; Ohoka, Y.; Nakashima, K.

10.1101/2025.04.28.651124 — biochemistry — Posted on 2025-05-08

4680 Odors drive feeding through gustatory receptor neurons in Drosophila

Wei, H.-p.; Lam, T. K. C.; Kazama, H.

10.1101/2022.03.09.483541 — neuroscience — Posted on 2025-05-08

4681 Whole-genome sequencing revealed local genetic differences and multi-layered genetic structure in brown bear (Ursus arctos) populations

Endo, Y.; Osada, N.; Mano, T.; Abramov, A. V.; Masuda, R.

10.1101/2025.04.21.649633 — evolutionary biology — Posted on 2025-05-07

4682 Influence of past climate changes and human-mediated introduction on patterns of genetic diversity distribution of the Papuan nutmeg (Myristica argentea) Warb.

Kusuma, J.; Milaba, A. C.; Paramitha, A.; Malaval, V.; Sari, M. N.; Nurhuda, C.; Couderc, M.; Scarcelli, N.; Watts, J.; Duminil, J.

10.1101/2025.02.05.636754 — evolutionary biology — Posted on 2025-05-07

4683 Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

Ma, S.; Yang, B.; Sun, Y.; Wang, X.; Guo, H.; Liu, R.; Ye, T.; Kang, C.; Chen, J.; Jiang, L.

10.1101/2024.10.07.616983 — microbiology — Posted on 2025-05-07

4684 Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling

Wang, G.; Qi, W.; Huang, R.; Wang, L.

10.1101/2024.12.23.630063 — neuroscience — Posted on 2025-05-07

4685 Beyond dichotomy: ultrasonic vocalizations of rats convey more than sad and happy

Wada, R.; Hakataya, S.; Tachibana, R. O.; Shiramatsu, T. I.; Ito, T.; Kanno, K.; Koshiishi, R.; Matsumoto, J.; Saito, Y.; Toya, G.; Okabe, S.; Okanoya, K.

10.1101/2024.12.09.627446 — animal behavior and cognition — Posted on 2025-05-07

4686 Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations

Zhang, X.; Yang, J.; Zhu, L.; Sachdev, N.; Mooney, J. A.; Sankararaman, S.; Lohmueller, K. E.

10.1101/2025.05.07.652751 — evolutionary biology — Posted on 2025-05-07

4687 Introducing the Y chromosome ancestral reference sequence - Improving the capture of human evolutionary information

Koksal, Z.; Preussner, A.; Leinonen, J.; Tukiainen, T.

10.1101/2025.05.07.652589 — evolutionary biology — Posted on 2025-05-07

4688 Genetic modification of Clostridium kluyveri for heterologous n-butanol and n-hexanol production

Schlaiss, C.; Baur, S. T.; Marsh, J. W.; Gemeinhardt, K.; Angenent, L. T.

10.1101/2025.05.05.652178 — microbiology — Posted on 2025-05-07

4689 Incorporation of collagen into Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia pseudomallei biofilms enhances their elasticity and resistance against phagocytic clearance

Zhou, X.; McGovern, A.; Wells, M. J.; Verma, D.; Currie, H.; Raka, A. M.; Shen, J.; Brown, K.; Robertson-Anderson, R.; Gordon, V. D.

10.1101/2023.10.25.564018 — microbiology — Posted on 2025-05-07

4690 Neural dynamics of an extended frontal lobe network in goal-subgoal problem solving

Mione, V.; Achterberg, J.; Kusunoki, M.; Buckley, M. J.; Duncan, J.

10.1101/2025.05.06.652442 — neuroscience — Posted on 2025-05-07

4691 Synergistic short-term synaptic plasticity mechanisms for working memory

Fiebig, F.; Chrysanthidis, N.; Lansner, A.; Herman, P. A.

10.1101/2025.05.07.652583 — neuroscience — Posted on 2025-05-07

4692 Soma to neuron communication links stress adaptation to stress avoidance behavior

Witrado, J.; Gundrum, E.; Veroli, M. V.; Mullett, S. J.; Gelhaus, S. L.; Lamitina, T.

10.1101/2025.05.07.652728 — physiology — Posted on 2025-05-07

4693 Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth

Ma, Y.; Ayadhury, S.; Singh, S.; Vashishath, Y.; Ozdemir, C.; McKee, T. D.; Nguyen, N.; Basi, A.; Mak, D.; Gomez, J.; Huse, J. T.; Noor, S.; Winkowski, D.; Baird, R.; Weinberg, J. S.; Lang, F. F.; Burks, J.; Bozdag, S.; Seeley, E. H.; Ene, C. I.

10.1101/2025.04.30.651361 — cancer biology — Posted on 2025-05-07

4694 EVA: a Foundation Model Advancing Translational Drug Development in Immuno-Inflammation

Fouche, A.; Bruley, A.; Corney, M.; Marschall, P.; Bouget, V.; Duquesne, J.

10.1101/2025.05.02.651839 — bioinformatics — Posted on 2025-05-07

4695 Targeted genomic surveillance of insecticide resistance in African malaria vectors

Nagi, S. C.; Lucas, E. R.; Ashraf, F.; Mugoya, T.; Lukyamuzi, E.; Summers, S.; Yee, C. K.; Jacob, C. G.; Nganga, H. N.; Pemberton, T.; Essandoh, J.; Lukindu, M.; Kabore, H.; Sawadogo, G.; Williams, J.; Van t Hof, A. E.; Hernandez-Koutoucheva, A.; Hubbart, C.; Rowlands, K.; Jeffreys, A.; Goodwin, S.; Park, N.; Ariani, C.; Egyir-Yawson, A.; Goncalves, S.; Rajatileka, S.; Rockett, K.; Simpson, V. J.; Miles, A.; Weetman, D.; Kayondo, J.; Nolan, T.; Donnelly, M. J.

10.1101/2025.02.14.637727 — genomics — Posted on 2025-05-07

4696 Signatures of selective sweeps in urban and rural white clover populations

Santangelo, J.; Johnson, M.; Ness, R.

10.1101/2024.10.30.621108 — evolutionary biology — Posted on 2025-05-07

4697 Growth Factor-Independent mTORC1 Signaling Promotes Primary Cilia Length via Suppression of Autophagy

Shin, J.; Cormerais, Y.; Tighanimine, K.; Niroula, P.; Cisse, M. Y.; Lapp, S. C.; Kalafut, K. C.; Schrotter, S.; Manning, B. D.

10.1101/2025.05.07.652626 — cell biology — Posted on 2025-05-07

4698 Enhancement of activation-induced T cell proliferation by SIRPG in a CD47-independent manner

Marguerie, F.; Saifi, M. A.; Geary, B.; Barnes, D.; Jonsson, A. H.; Ho, I.-C.

10.1101/2025.05.01.651731 — immunology — Posted on 2025-05-07

4699 SmartEM: machine-learning guided electron microscopy

10.1101/2023.10.05.561103 — neuroscience — Posted on 2025-05-07

4700 Unbiased Population-Based Statistics to Obtain Pathologic Burden of Injury after Experimental TBI

Smith, G.; Santana-Gomez, C. E.; Staba, R.; Harris, N. G.

10.1101/2025.04.03.647083 — neuroscience — Posted on 2025-05-07

4701 Lateralised modulation of posterior alpha oscillations by closed loop auditory stimulation during memory retention

Hebron, H.; Dimitrova, R.; Jaramillo, V.; Dijk, D.-J.; Violante, I. R.

10.1101/2025.05.07.652437 — neuroscience — Posted on 2025-05-07

4702 Early Emergence of Projection-subtype fate-restricted Radial Glial Progenitors Orchestrates Neocortical Neurogenesis.

Varela-Martinez, I.; Villalba, A.; Garcia-Marques, J.; Hippenmeyer, S.; Nieto, M.

10.1101/2025.05.07.652665 — neuroscience — Posted on 2025-05-07

4703 The Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

Ahn, A.; Kim, J. J.; Slusher, A. L.; Ying, J. Y.; Zhang, E. Y.; Ludlow, A. T.

10.1101/2024.11.21.624690 — physiology — Posted on 2025-05-07

4704 Downscaling local distribution of cattle over Guadeloupe archipelago: an adapted method for disaggregating census data

Dufleit, V.; Guerrini, L.; Gilbert, M.; Da Re, D.; Etter, E.

10.1101/2025.05.02.651856 — bioinformatics — Posted on 2025-05-07

4705 Tissue engineered endothelial keratoplasty with controlled endothelial cell density: proof of concept and paving the way for super TEEKs

Aouimeur, I.; Coulomb, L.; Fraine, S.; HE, Z.; Bonnet, G.; Sagnial, T.; Travers, G.; XXX, S.; Mauclair, C.; Moisan, A.; Gain, P.; thuret, G.; Corantin, M.

10.1101/2025.05.01.651674 — bioengineering — Posted on 2025-05-07

4706 Argonaute-siRNA loading via the RNA-binding protein RDE-4 in C. elegans

Knittel, T. L.; Montgomery, B. E.; Sprister, R. A.; Magelky, C. N.; Smith, M. J.; Soto-Ojeda, M.; Guthrie, M.; Phillips, C. M.; Montgomery, T.

10.1101/2025.05.06.652520 — biochemistry — Posted on 2025-05-07

4707 Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance

Canalda-Baltrons, A.; Silcocks, M.; Hall, M. B.; Theys, D.; Chang, X.; Viberg, L. T.; Sherry, N. L.; Coin, L.; Dunstan, S. J.

10.1101/2025.05.07.652570 — genomics — Posted on 2025-05-07

4708 The adaptive state determines the impact of mutations on evolving populations

Weh, M. T.; Kumar, P.; Marusyk, V.; Marusyk, A.; Basanta, D.

10.1101/2024.12.11.627972 — evolutionary biology — Posted on 2025-05-07

4709 Can whole-lake algal biomass be captured by one-dimensional modeling approaches? An exploration using 'Lake2D'

Harlin, H.; Larsson, K.; Diehl, S.

10.1101/2025.05.02.651842 — ecology — Posted on 2025-05-07

4710 A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity

Monzel, A. S.; Devine, J.; Kapri, D.; Enriquez, J. A.; Trumpff, C.; Picard, M.

10.1101/2025.02.03.635951 — cell biology — Posted on 2025-05-07

4711 FRAP-in-SR: Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 foci

Wu, C.; Manjarrez-Gonzalez, J. C.; Choudhury, M. S.; Shamkhi, N.; Ding, S.; Nair, V. M.; Draviam, V. M.

10.1101/2025.05.07.652606 — cell biology — Posted on 2025-05-07

4712 Recombination and the Species Structure of the Genus Bacteroides

Ochman, H.; Patel, A. M.

10.1101/2025.05.07.652691 — microbiology — Posted on 2025-05-07

4713 Agriculture alters protein evolution of nitrogen cycling genes in soil bacteria at a global scale

Ghaly, T. M.; Shah, B. S.; Coleman, N. V.; Elbourne, L.; Le Roux, J.; Gillings, M.; Paulsen, I. T.; Tetu, S. G.

10.1101/2025.05.07.652758 — microbiology — Posted on 2025-05-07

4714 Dynamics of Bacterial and Viral Transmission in Experimental Microbiota Transplantation

Weagley, J.; Cardenas, L. A. C.; Romani, A.; Sullender, M.; Aggarwal, S.; Makimaa, H.; Hogarty, M.; Rodgers, R.; Kennedy, E.; Foster, L.; Schriefer, L. A.; Baldridge, M. T.

10.1101/2025.01.15.633206 — microbiology — Posted on 2025-05-07

4715 The acetylation of the histone-like protein HBsu at specific sites alters gene expression during sporulation in Bacillus subtilis

Popova, L.; Schreiber, O. R.; Pandey, H.; Papachristou, C.; Carabetta, V. J.

10.1101/2025.05.07.652692 — microbiology — Posted on 2025-05-07

4716 Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance

10.1101/2025.05.06.652565 — microbiology — Posted on 2025-05-07

4717 A case-control neuroimaging investigation of chronic Zika virus-infected adults

Jun, S.; Bido-Medina, R. O.; Oviedo, J.; Miches, I.; Llano, D.; Tusen, L.; Stoeter, P.; Rodriguez, M.; Sadaghiani, S.

10.1101/2025.03.05.641727 — neuroscience — Posted on 2025-05-07

4718 Caspase cleavage of APP contributes to amyloid beta-protein induced synaptic injury

Brea Midthune, B. x.; Park, G.

10.1101/2025.04.30.651606 — neuroscience — Posted on 2025-05-07

4719 Trait reward sensitivity and behavioral motivation shape connectivity between the default mode network and the striatum during reward anticipation

Wyngaarden, J. B.; Nambiar, A.; Dennison, J. B.; Alloy, L. B.; Fareri, D.; Jarcho, J. M.; Smith, D. V.

10.1101/2025.04.17.649386 — neuroscience — Posted on 2025-05-07

4720 Microstructural organization of Superior Longitudinal Fasciculus and Cingulum Bundle support metacognition driven cognitive offloading

Zheng, Y.; Bo, B.; Wang, D.; Liu, Y.; Gilbert, S. J.; Li, Y.; Kwok, S. C.

10.1101/2024.08.24.609527 — neuroscience — Posted on 2025-05-07

4721 Transcriptome and metabolome analyses reveal novel genetic targets for L-tryptophan overproduction in Corynebacterium glutamicum

Dong, Y.; Gao, R.; Qin, N.; Liu, K.; Liu, Y.; Chen, Z.

10.1101/2025.05.07.652659 — synthetic biology — Posted on 2025-05-07

4722 Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation

Ahammad, R. U.; Spencer, B.; Quach, B.; Salehi, S.; Rissman, R. A.

10.1101/2025.05.01.651722 — pharmacology and toxicology — Posted on 2025-05-07

4723 cytoGPNet: Enhancing Clinical Outcome Prediction Accuracy Using Longitudinal Cytometry Data in Small Cohort Studies

Zhang, J.; Sun, L.; Ready, N. E.; Guo, W.; Lin, L.

10.1101/2025.05.01.651729 — bioinformatics — Posted on 2025-05-07

4724 Bonferroni's correction not Tukey's should be used for making pairwise comparisons in experiments with few replicates.

zweifach, a.

10.1101/2025.05.01.651705 — bioinformatics — Posted on 2025-05-07

4725 Multimodal imaging reveals multiscale mechanical interplay in vertebral endplate microarchitecture during intervertebral disc loading

Parmenter, A. L.; Newham, E.; Sharma, A.; Disney, C. M.; Deyhle, H.; Bosi, F.; Terrill, N. J.; Bay, B. K.; Pitsillides, A. A.; Gupta, H. S.; Lee, P. D.

10.1101/2024.08.19.608559 — bioengineering — Posted on 2025-05-07

4726 Single particle dynamics of protein aggregation and disaggregation in the presence of the sHsp proteins IbpAB

Roth, A.; Puchalla, J.; Rye, H.

10.1101/2025.05.07.652671 — biochemistry — Posted on 2025-05-07

4727 Small molecule inhibition of CPSF3 impacts R-loop distribution

Corey, D. R.; Hu, J.; Hofman, C.; Tse, V.

10.1101/2025.05.07.652284 — biochemistry — Posted on 2025-05-07

4728 Ultrathin Liquid Cells for Microsecond Time-Resolved Cryo-EM

Curtis, W. A.; Hruby, J.; Kruger, C. R.; Barrass, S. V.; Drabbels, M.; Lorenz, U. J.

10.1101/2025.05.05.652279 — biochemistry — Posted on 2025-05-07

4729 Peptidic tryptophan halogenation by a promiscuous flavin-dependent enzyme

Rice, A. J.; Gadgil, M. G.; Bisignano, P.; Stein, R. A.; Mchaourab, H. S.; Mitchell, D. A.

10.1101/2025.01.12.632611 — biochemistry — Posted on 2025-05-07

4730 Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment

Mendiola, A. J. P.; Rutkowsky, J. M.; Neier, K. E.; Hakam, S.; Sharifi, O.; Donnelly, C.; Torres, C.; Hernandez, C.; Yasui, D. H.; Ramsey, J. J.; LaSalle, J. M.

10.1101/2025.05.01.651733 — animal behavior and cognition — Posted on 2025-05-07

4731 Convergent evolution of sex chromosomes in two palm species,Phoenix dactylifera and Kerriodoxa elegans.

TESSAROTTO, H.; Beule, T.; Cherif, E.; ORJUELA, J.; Farhat, P.; LINDSTROM, A.; LEMANSOUR, A.; Santoni, S.; Kafer, J.; ABERLENC, F.

10.1101/2024.06.27.600560 — evolutionary biology — Posted on 2025-05-07

4732 Ontogeny of the vagal gut-brain axis

Lough, K. J.; Knox, J. C.; Moy, S. S.; King, J. S.; Williams, S. E.

10.1101/2025.05.01.651736 — developmental biology — Posted on 2025-05-07

4733 Promoter strength and position govern promoter competition

Koska, M.; Swigut, T.; Boettiger, A. N.; Wysocka, J.

10.1101/2025.05.06.652547 — molecular biology — Posted on 2025-05-07

4734 The lac repressor strikes a balance between inducibility and strength of repression

Yuan, J.; Luking, M.; Zikrin, S.; Sen, B.; Marklund, E.; Fange, D.; Elf, J.

10.1101/2025.05.07.652604 — molecular biology — Posted on 2025-05-07

4735 Substitutions in RNA-binding protein Hrp1 map a potential interaction surface with the yeast RNA polymerase II elongation complex

Wang, M.; Arora, P.; Kaplan, C. D.; Brow, D. A.

10.1101/2025.05.07.652672 — molecular biology — Posted on 2025-05-07

4736 Carbon and microbes from thawing palsas and peats do not reach a wider fluvial system

Tuomela, N.; Elovaara, S.; Hultman, J.; Kaartokallio, H.; Thomas, D.

10.1101/2025.05.07.652394 — microbiology — Posted on 2025-05-07

4737 ZapC crosslinks FtsZ filaments through a dual-binding mechanism modulated by the intrinsically disordered linker of FtsZ

Du, S.; Li, Y.; Gong, H.; Zhang, R.; Cui, Y.; Chen, X.; Lutkenhaus, J.

10.1101/2025.05.07.652675 — microbiology — Posted on 2025-05-07

4738 Comparative genomics of DH5α-inhibiting Escherichia coli isolates from human feces reveals common co-occurrence of bacteriocin genes with virulence factors and antibiotic resistance genes.

Er, S.; Ding, Y.; Tan, L. W. L.; Teo, Y. Y.; Nagarajan, N.; Seedorf, H.

10.1101/2025.05.07.652706 — microbiology — Posted on 2025-05-07

4739 Growth of Gram-negative uropathogens in human urine under hypoxic conditions produces clinically relevant metabolomic profiles

Eladawy, M.; McCartney, A. L.; Garner, A. C.; Hoyles, L.

10.1101/2025.05.07.652693 — microbiology — Posted on 2025-05-07

4740 Algal Betaine Triggers Bacterial Hydrogen Peroxide Production that Promotes Algal Demise

Narvaez-Barragan, D. A.; Yuda, L.; Lipsman, V.; Yahalomi, D.; Malitsky, S.; Segev, E.

10.1101/2025.05.07.652642 — microbiology — Posted on 2025-05-07

4741 When things add up: environmental structure and microbial interactions drive antibiotic-resistance plasmid evolution

Zandbergen, L. E.; Bustamante, M.; Luursema, J.-M.; Hackl, T.; de Vos, M. G.

10.1101/2025.05.07.652652 — microbiology — Posted on 2025-05-07

4742 Locus Coeruleus to Medial Prefrontal Cortex Noradrenergic Neural Circuit Modulates States of Consciousness during Sevoflurane Anesthesia in Mice

Shao, W.; Yang, Y.; Wu, Y.; Di, X.; Zhang, Z.; Liu, L.; Gu, L.; Xu, X.; Zhang, Z.; Gu, J.; Zhang, H.

10.1101/2025.05.01.651682 — neuroscience — Posted on 2025-05-07

4743 Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach

Agnorelli, C.; Peill, J.; Sawicka, G.; Kurtin, D. L.; Shatalina, E.; Ahmad, K.; Wall, M. B.; Rua, C.; Godfrey, K.; Ertl, N.; Searle, G.; Zhou, K.; Weiss, B.; Fagiolini, A.; Carhart-Harris, R.; Matthews, P. M.; Rabiner, E.; Nutt, D.; Erritzoe, D.

10.1101/2025.05.01.651686 — neuroscience — Posted on 2025-05-07

4744 Chronic HDACi emends microglial differentiation and neurological disease in a mouse model of intellectual disability

Alam, M. S.; Padmanabhan, P. K.; McArdle, R.; Lopez-Ramirez, A.; MysoreRajashekara, A.; Knopp, J.; Kim, G.; Centeo, M. V.; Apkarian, A. V.; Swarup, V.; Haldar, K.

10.1101/2025.05.01.651719 — neuroscience — Posted on 2025-05-07

4745 PanScan: A Tool for Tertiary Analysis of Human Pangenome Graphs

Uddin, M.; Balan, B.; Hanif, M.; Hashmi, A.; Kumail, M.; Bineshaq, S.; Alyazeedi, T.; Naveed, R.; Murtaza, M.; Jamalalail, B.; Elsokary, H.; Alobathani, M.; Mohamed, N.; Kondaramage, D.; Advani, D.; Ibrahim, A.; Shiyas, S.; Sares, N.; Alkhnbashi, O.; Duplessis, S.; Almarri, M.; Nassir, N.; Alsheikhali, A.

10.1101/2025.05.01.651685 — bioinformatics — Posted on 2025-05-07

4746 Within- and Between-Assessor Reliability of Lower-Limb Inter-Joint Coordination During Gait in Individuals With and Without Cerebral Palsy

Dussault Picard, C.; Cherni, Y.; Fonseca, M.; Carcreff, L.; Leboeuf, F.; Armand, S.

10.1101/2025.05.01.651648 — bioengineering — Posted on 2025-05-07

4747 Elp3 uses a conserved molecular tunnel to transport acetate between distant active sites and catalyze tRNA wobble base modification

Geissler, E. P.; Moawad, Y.; Roehling, P. N.; Martin, K.; Asare-Okai, P. N.; Mugridge, J. S.

10.1101/2025.05.07.652618 — biochemistry — Posted on 2025-05-07

4748 LAMPrey: a standardised method for analysing quantitative LAMP (qLAMP) and qPCR reactions using the inflection cycle threshold iCt

Bates, A.; Li, J.; Rivero, F.; Wollenberg Valero, K. C.

10.1101/2025.05.06.651076 — molecular biology — Posted on 2025-05-07

4749 Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata

Connell, S. J.; Crotts, S.; Reis, R.; Lensing, M.; Kahl, P.; Henderson, N.; Ayush, O.; Zhu, Z.; Ortolan, L. S.; Harty, J.; Goverman, J.; Jabbari, A.

10.1101/2025.05.07.650678 — immunology — Posted on 2025-05-07

4750 Staphylococcus aureus-Induced Degeneration of Nociceptive Neurons in Caenorhabditis elegans

DiLoreto, E. M.; Gonzalez, X.; Wani, K. A.; Shen, J.; Irazoqui, J. E.; Srinivasan, J. E.

10.1101/2025.05.01.651706 — neuroscience — Posted on 2025-05-07

4751 Alzheimer's disease risk gene Wwox protects against amyloid pathology through metabolic reprogramming

Lucas-Clarke, H. J.; Maddison, D. C.; Amadio, L.; Buhl, E.; O'Hare, K.; Regnault, C.; Peters, O. M.; Hodge, J. J. L.; Smith, G. A.

10.1101/2025.05.01.651195 — neuroscience — Posted on 2025-05-07

4752 Autophagy driven by VPS34 enables differentiated cell plasticity and cancer initiation

Ramos-Delgado, F.; Shalhoub, H.; Guyon, C.; Handschin, C.; Cerapio-Arroyo, P.; DAngelo, R.; Therville, N.; Villard, A.; Cayron, C.; Valle, C.; Sarot, E.; Dussere, N.; Di-Luoffo, M.; Rebours, V.; Couvelard, A.; Joffre, C.; de Oliveira, H.; Dufresne, M.; Thibault, B.; Guillermet-Guibert, J.

10.1101/2025.05.02.651270 — pathology — Posted on 2025-05-07

4753 Lysyl oxidase promotes actin-dependent neutrophil activation and cytotoxicity in diabetes: Implications for diabetic retinopathy

Agarwal, M.; Chandrakumar, S.; Santiago Tierno, I.; Lessieur, E. M.; Bollinger, Z. R.; Kern, T. S.; Ghosh, K.

10.1101/2025.05.02.651525 — pathology — Posted on 2025-05-07

4754 Miro1 knockout inhibits mouse breast cancer tumorigenesis

Termos, R.; Muskat, A.; Shannon, N.; McCoy, M.; Termos, A.; Palmer, C.; Chang, M. C.; Cunniff, B.

10.1101/2025.05.06.650999 — cancer biology — Posted on 2025-05-07

4755 Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression

Tankka, A.; Einstein, J. M.; Zhou, C. J.; Pham, V. N.; Zhang, Y.; Naritomi, J. T.; Nguyen, G. G.; Mizrahi, O.; Perelis, M.; Sarsam, J.; Tan, F. E.; Kaufman, D. S.; Antal, C. E.; Yeo, G. W.

10.1101/2025.05.01.651692 — cancer biology — Posted on 2025-05-07

4756 Regenie.QRS: computationally efficient whole-genome quantile regression at biobank scale

Wang, F.; Wang, C.; Wang, T.; Masala, M.; Fiorillo, E.; Devoto, M.; Cucca, F.; Ionita-Laza, I.

10.1101/2025.05.02.651730 — bioinformatics — Posted on 2025-05-07

4757 Beyond Natural Antibodies: Scaffold-Based Generation of Novel Anti-3CLpro Nanobody Nb01

Zhan, Z.; Luo, C.; Xiong, J.; Jiang, Y.; Li, Y.; Huang, F.; Cai, Y.; Liu, J.

10.1101/2025.05.06.652338 — bioinformatics — Posted on 2025-05-07

4758 Data-driven feedback augments ultrasound nanotheranostics in brain tumors

Lee, H.; Menezes, V.; Zeng, S.; Kim, C.; Baseman, C. M.; Kim, J. H.; Padmanabhan, S.; Premdas, P.; Djeddar, N.; Bryksin, A. V.; Pandey, N.; Anastasiadis, P.; Kim, A. J.; MacDonald, T. J.; Bettegowda, C.; Woodworth, G. F.; Hermann, F. J.; Arvanitis, C.

10.1101/2025.05.01.651328 — bioengineering — Posted on 2025-05-07

4759 Not All Butterflies Are Monarchs: Compass Systems in the Red Admiral (Vanessa atalanta), a European Diurnal Migrant

Pakhomov, A.; Shapoval, N.; Shapoval, A.; Kishkinev, D.

10.1101/2025.05.01.651646 — animal behavior and cognition — Posted on 2025-05-07

4760 Orthologs of an essential orphan gene vary in their capacities for function and subcellular localization in Drosophila melanogaster

Patel, P. H.; Eicholt, L. A.; Lange, A.; McDermott, K. L.; Bornberg-Bauer, E.; Findlay, G. D.

10.1101/2025.05.01.651694 — genetics — Posted on 2025-05-07

4761 Optimization of wheat breeding programs using an evolutionary algorithm achieves enhanced genetic gain through strategic resource allocation

Hassanpour, A.; Rohde, A.; Simianer, H.; Pook, T.

10.1101/2025.05.01.651521 — genetics — Posted on 2025-05-07

4762 Field-validation of multiple species distribution models shows variation in performance for predicting Aedes albopictus distributions at the invasion edge

Shattuck, A. V.; Hollingsworth, B. D.; Skrotzki, J.; Campbell, S. R.; Romano, C. L.; Murdock, C. C.

10.1101/2025.05.01.651656 — ecology — Posted on 2025-05-07

4763 Fertility recovery after combined adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy in mice

Lu, X.; Turathum, B.; Chian, R.-C.; Liu, Y.

10.1101/2025.05.01.651671 — developmental biology — Posted on 2025-05-07

4764 Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function

Prabhala, P.; Freiman, S.; Gvazava, N.; Sharma, J.; Wijk, S.; Kanszenbach, K.; Lang, S.; Cattani, R.; Wigen, J.; Bryder, D.; Soneji, S.; Flygare, J.; Tufvesson, E.; Bjermer, L.; Wagner, D. E.; Westergren-Thorsson, G.; Magnusson, M.

10.1101/2025.05.06.650933 — molecular biology — Posted on 2025-05-07

4765 Antibody Binding and Neutralizing Targets within the Predicted Structure of the Poxvirus Multiprotein Entry-Fusion Complex

Yu, H.; Resch, W.; Cotter, C. A.; Belghith, A. A.; Ignacio, M. A.; Earl, P. L.; Cohen, G. H.; Moss, B.

10.1101/2025.05.07.652617 — microbiology — Posted on 2025-05-07

4766 Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis

Fry, L.; de Jesus, F. N.; Carneiro, M. B.; Roys, H.; Bowlin, A.; Peters, N. C.; von der Weid, P.-Y.; Weinkopff, T.

10.1101/2025.05.01.651666 — immunology — Posted on 2025-05-07

4767 The gonococcal vaccine candidate antigen NGO1701 is a N. gonorrhoeae periplasmic copper storage protein

Roe, S. K.; Mazgaj, R.; Zhu, T.; Esmaeeli, M.; Lewis, L. A.; Genco, C.; Waldron, K. J.; Massari, P.

10.1101/2025.05.01.651437 — immunology — Posted on 2025-05-07

4768 Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic Acids

Mank, M. M.; Zoller, K. A.; Fastiggi, V. A.; Ather, J. L.; Poynter, M. E.

10.1101/2025.05.01.650510 — immunology — Posted on 2025-05-07

4769 Neural signature underlying the effect of intranasal vasopressin on emotional responses to spontaneous social comparison

Li, X.; Zheng, Z.; Tian, X.; Long, A.; Yang, B.; Gu, R.; Ma, Y.; Luo, W.; Feng, C.

10.1101/2025.05.01.651624 — neuroscience — Posted on 2025-05-07

4770 Chronic nicotine treatment enhanced cognition and reduced neuroinflammation in the gp120 transgenic mouse model of neuroHIV

Ayoub, S. M.; Dexter, T.; Noback, M.; Flesher, M. M.; Achim, C.; Fields, J. A.; Minassian, A.; Brody, A.; Young, J. W.

10.1101/2025.05.03.651604 — neuroscience — Posted on 2025-05-07

4771 A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson's disease

Acquah, E.; Hood, R. J.; Lin, C.-A. J.; Li, Q.-X.; Gordon, L.; Martin, K. L.; Aryal, R.; Milward, A. E.; Johnstone, D. M.

10.1101/2025.05.06.648286 — neuroscience — Posted on 2025-05-07

4772 Anxiety state-related task disengagement varies with trait anxiety

Sayali, C.; Heling, E.; Cools, R.

10.1101/2025.05.04.651621 — neuroscience — Posted on 2025-05-07

4773 Identification of modulated whole-brain dynamical models from nonstationary electrophysiological data

Schwamb, A.; Yu, Z.; Ching, S.

10.1101/2025.05.01.651677 — neuroscience — Posted on 2025-05-07

4774 Adaptive learning of a naturalistic bimanual task in virtual reality

Varghese, R.; Rossi, C.; Malone, L. A.; Bastian, A. J.

10.1101/2025.05.01.651653 — neuroscience — Posted on 2025-05-07

4775 Anticipated action goals structure spatial organisation in visual working memory following self-movement

Chawoush, B.; Draschkow, D.; van Ede, F.

10.1101/2025.05.01.651644 — neuroscience — Posted on 2025-05-07

4776 Vitamin D regulates olfactory function via dual transcriptional and mTOR-dependent translational control of synaptic proteins

Ren, P.; cao, r.; ye, x.; pang, w.; Bi, Q.; Huang, M.; Zhou, Q.; Ye, D.; Xiang, W.; Xiao, L.

10.1101/2025.05.02.651619 — neuroscience — Posted on 2025-05-07

4777 miRNA-mRNA network analysis identifies PAX5 as a potential regulator of adaptive immune response in COPD

Gentili, M.; De Marzio, M.; Hobbs, B.; Hersh, C. P.; Ryu, M. H.; Kuijjer, M. L.; Cho, M. H.; Moll, M.; Tern, C.; Castaldi, P.; Glass, K.

10.1101/2025.05.06.651484 — systems biology — Posted on 2025-05-07

4778 A physiology-based mathematical model of the renin-angiotensin system, bone remodeling, and calcium homeostasis: Effects of estrogen and renin-angiotensin system inhibitors

Stadt, M.; Layton, A. T.

10.1101/2025.05.01.651663 — physiology — Posted on 2025-05-07

4779 Targeted Molecular MRI of Colorectal Cancer by Antibody Functionalized Hyperpolarized Silicon Particles

Whiting, N.; Hu, J.; Pudakalakatti, S.; McCowan, C.; Ramezani, S.; Davis, J.; Millward, N. Z.; Engel, B.; Liu, J.; Gellci, K.; Seo, H.; Brown, D.; Enriquez, J. S.; Menter, D. G.; Millward, S. W.; Gammon, S. T.; Piwnica-Worms, D.; Farach-Carson, M. C.; Carson, D.; Constantinou, P. E.; Bhattacharya, P.

10.1101/2025.05.06.651536 — cancer biology — Posted on 2025-05-07

4780 Insights into gallbladder cancer pathogenesis from a living organoid gallbladder cholangiocyte biorepository

Dutta, A.; Chowdhury, N.; Selvarajan, A. V.; Banerjee, P.; Kar, A.; Chandra, S.; Sunderam, U.; Ganguli, D.; Dutta, T.; Basak, D.; Satheeshkumar, S. J.; Ragate, A. S.; Krishnan, S.; Sen, S.; Roy, M. K.; Banerjee, S.; Srinivasan, R.; Roy, P.; Saha, V.; Dutta, A.; GuhaSarkar, D.

10.1101/2025.05.01.651639 — cancer biology — Posted on 2025-05-07

4781 Medlib: A Feature-Rich C/C++ Library for Exact Alignment of Nanopore Sequences Using Multiple Edit Distance

Rafeie, M.; Vafaee, F.; Faridani, O. R.

10.1101/2025.05.01.651420 — bioinformatics — Posted on 2025-05-07

4782 Separable Spatial Single-cell Transcriptome Representation Learning via Graph Transformer and Hyperspherical Prototype Clustering

Fu, L.; Wang, P.; Xu, G.; Lu, J.; Sun, H.; Wu, D.

10.1101/2025.05.01.651634 — bioinformatics — Posted on 2025-05-07

4783 GENETIC ENGINEERING THROUGH QUANTUM CIRCUITS: CONSTRUCTION OF CODES AND ANALYSIS OF GENETIC ELEMENTS BIOBLOQU

Pascoal, P. V.; Bambil, D.; Tacca, L. M. A. d.; Lima, R. N.; Oliveira, M. A. d.; Vainstein, M. H.; Rech, E.

10.1101/2025.05.02.651535 — bioinformatics — Posted on 2025-05-07

4784 RPSLearner: A novel approach based on random projection and deep stacking learning for categorizing NSCLC

Wu, X.; Wang, J.; Wan, S.

10.1101/2025.05.01.651699 — bioinformatics — Posted on 2025-05-07

4785 Modeling host-microbe interactions in immunocompetent engineered human gut tissues

Lopez-Sandoval, R.; Harter, M. F.; Yu, Q.; Gaspa-Toneu, L.; Cubela, I.; Kromer, K.; Aubert, J.; Filip, A. M.; Kaltenbach, L.; Almato-Bellavista, M.; Akkerman, N.; Bollen, Y.; Munteanu, S.; Fidelin, J.; Augustin, A.; Schori, C.; Bickle, M.; Lutolf, M. P.; Beumer, J.; Recaldin, T.; Nikolaev, M.; Gjorevski, N.; Camp, J. G.

10.1101/2025.05.02.651468 — bioengineering — Posted on 2025-05-07

4786 A 4D Bioprinting Platform to Engineer Anisotropic Musculoskeletal Tissues by Spatially Patterning Microtissues into Temporally Adapting Support Baths

Spagnuolo, F. D.; Soares Kronemberger, G.; Kelly, D.

10.1101/2025.05.01.651636 — bioengineering — Posted on 2025-05-07

4787 Thermal proteome profiling identifies glucose binding proteins involved in metabolic disease

Ferguson, I. D.; Meservey, L. M.; Tien, V.; Miao, W.; Lopez-Pajares, V.; Porter, D. F.; Khavari, P.

10.1101/2025.05.06.651509 — biochemistry — Posted on 2025-05-07

4788 A Chromosome-Scale Genome of Nanomia septata Reveals Extensive Rearrangement But No Clear Driver of the Unique Colony-Level Organization of Siphonophores

Ahuja, N.; Schultz, D. T.; Destanovic, D.; Church, S. H.; Picciani, N.; Munro, C.; Kon-Nanjo, K.; Kon, T.; Manko, M. K.; Shi, W.; Haddock, S. H. D.; Simakov, O.; Dunn, C. W.

10.1101/2025.05.01.651713 — genomics — Posted on 2025-05-07

4789 Identification of immune-mitophagy related gene in PD based on single-cell sequencing and Mendelian randomization

Dong, x.; Wu, G.; Zhang, L.; Li, Q.; Li, Y.; Jin, F.; Li, R.; Ling, Y.; Xu, Y.

10.1101/2025.05.01.651665 — genetics — Posted on 2025-05-07

4790 Patterns of grass (Poaceae) species distribution and richness across India

Mande, M.; Joshi, A. A.; Paramjyothi, H.; Ratnam, J.; Sankaran, M.

10.1101/2025.05.06.651586 — ecology — Posted on 2025-05-07

4791 Priority Effects Can Shape Strain-Level Community Assembly and Function in a Bioluminescent Symbiosis

Roman, E. D.; Nebhut, A. N.; Fukami, T. D.; Gould, A. L.

10.1101/2025.05.01.651688 — ecology — Posted on 2025-05-07

4792 An oviposition pheromone, hexadecanoic acid, found on the eggs of Phlebotomus papatasi from Central Tunisia, attracts gravid females and stimulates oviposition.

Chelbi, I.; Zhioua, E.; Shocket, M.; Hamilton, J. G. C.

10.1101/2025.05.01.651664 — ecology — Posted on 2025-05-07

4793 A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

Iwasaki, K.; Carapeto, P.; Abarca, C.; Hela, F.; Sanjines, S.; Pena, S.; Le, S.; Pan, H.; Cahill, C.; Midha, A.; Diniz, J. A.; Baker, D.; Domanskyi, S.; Espinoza, S.; Pena, A.; Cigarroa, F. G.; Woolworth, J. L.; Chuang, J. H.; Garovic, V. D.; Kirkland, J.; Tchkonia, T.; Musi, N.; Kuchel, G. A.; Robson, P.; Aguayo-Mazzucato, C.

10.1101/2025.05.07.648438 — developmental biology — Posted on 2025-05-07

4794 Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Chudzik, K.; Guerreiro, I.; Kefalopoulou, S.; Abraham, A.; Schindler, M.; Ringel, A. R.; Nicodemi, M.; Solovei, I.; Chiariello, A. M.; Mundlos, S.; Kind, J.; Robson, M. I.

10.1101/2025.05.05.651267 — developmental biology — Posted on 2025-05-07

4795 An embryonic artery-forming niche reactivates in pulmonary arterial hypertension

Tian, W.; Wu, T. T.-H.; Gu, S.; Chang, J. L.; Huang, C.; Vinh, R.; Andruska, A. M.; Song, K. K.; Kim, D.; Zhu, Y.; Lee, S.; Pan, J.; Kao, P. N.; Desai, T.; Prince, L. S.; Butcher, L. D.; Jiang, X.; Rabinovitch, M.; Red-Horse, K.; Nicolls, M. R.

10.1101/2025.05.02.651303 — developmental biology — Posted on 2025-05-07

4796 Autophagy selectively clears ER in inflammation-induced muscle atrophy

Dueren, U. K.; Wei, A. A. J.; Gressler, A. E.; Popp, O.; Grumati, P.; Selbach, M.; Simon, A. K.; Sommer, T.

10.1101/2025.05.06.650963 — molecular biology — Posted on 2025-05-07

4797 Impact of Human Genetic Variation Underlying Resistance to Antigen-Specific Immunotherapy

Marone, R.; Asllanaj, E.; Capoferri, G.; Schwede, T.; Jeker, L. T.; Lepore, R.

10.1101/2025.05.02.651174 — immunology — Posted on 2025-05-07

4798 AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells

He, M.; DAulerio, R.; Pinho, L. G.; Doukoumopoulos, E.; Yong, T.; Vieira, R. C.; Oliveira, M.; Sedimbi, S.; Seitz, C.; Kuznetsov, N. V.; Zuriaga, M. A.; Kitamura, D.; Fuster, J. J.; Cotta-de-Almeida, V.; Strom, L.; Degn, S. E.; Westerberg, L.

10.1101/2025.05.02.651162 — immunology — Posted on 2025-05-07

4799 Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets

Derby, N.; Johnson, B. I.; Biswas, S.; Fischer, M.; Fancher, K. A.; Luevano-Santos, C.; Yusova, S.; Meyer, K. A.; Abraham, Y. M.; Lutz, S. S.; Fisher, C.; Pacheco, M. C.; Smedley, J. V.; Burwitz, B. J.; Sodora, D. L.

10.1101/2025.05.01.651668 — immunology — Posted on 2025-05-07

4800 Oxysterol Alterations in SOD1G93A ALS Rats: 25-Hydroxycholesterol and LPS-Binding Protein in Disease Progression

Lima, R. S.; Santos, R.; Chaves-Filho, A. B.; Trzan, I. F. L.; Inague, A.; Faria, R. L.; Dantas, L. S.; Pinto, I. F. D.; Medeiros, M. H. G.; Steiner, A. A.; Miyamoto, S.

10.1101/2025.05.05.650333 — neuroscience — Posted on 2025-05-07

4801 Summation of contrast across the visual field: a common "fourth root" rule holds from the fovea to the periphery

Baldwin, A. S.; Meese, T. S.

10.1101/2025.05.06.649158 — neuroscience — Posted on 2025-05-07

4802 Self-Motion Perception Influences Postural Sway More than Environmental Motion Perception

Anson, E. R.; Critelli, K.; Chen, E.; Staab, J. P.; Carpenter, M. G.; Crane, B. T.

10.1101/2025.05.02.651511 — neuroscience — Posted on 2025-05-07

4803 Unraveling Cross-Cellular Communication in Cannabis sativa Sex Determination: A Network Ontology Transcript Annotation (Nota) Analysis.

Orozco, L. R.; Weaver, A. E.; Pauli, C. C.; Grassa, C. J.; Vergara, D.; Baptista, A.; White, K.; Emery, B. F.; Castro, N. R. M.; Guerrero, R. F.; Keegan, B. C.; Kane, N. C.

10.1101/2025.05.05.650505 — systems biology — Posted on 2025-05-07

4804 Context-dependent spatial multicellular network motifs for single-cell spatial biology

Zamir, A.; Amitay, Y.; Tamir, Y.; Keren, L.; Zaritsky, A.

10.1101/2025.05.05.651422 — systems biology — Posted on 2025-05-07

4805 Dynamic Shape Modulation of Deflated and Adhered Lipid Vesicles

Wolfisberg, G. C.; Agudo-Canalejo, J.; Bittmann, P. C.; Dufresne, E. R.; Style, R. W.; Rebane, A. A.

10.1101/2025.05.06.650387 — biophysics — Posted on 2025-05-07

4806 AWmeta empowers adaptively-weighted transcriptomic meta-analysis

Hu, Y.; Wang, Z.; Hu, Y.; Feng, C.; Fang, Q.; Chen, M.

10.1101/2025.05.06.650408 — bioinformatics — Posted on 2025-05-07

4807 Contrasted effects of human pressure on biodiversity in the UK: a multi-taxonomic assessment using airborne environmental DNA

Tournayre, O.; Littlefair, J. E.; Garrett, N. R.; Brown, A. S.; Allerton, J. J.; Cristescu, M. E.; Clare, E. L.

10.1101/2025.05.01.651649 — ecology — Posted on 2025-05-07

4808 WITHDRAWN: Cortical interneurons require JNK signaling for migration regardlessof substrate and topographical environment

Smith, S.

10.1101/2025.04.22.650074 — neuroscience — Posted on 2025-05-07

4809 WITHDRAWN: How Bacterial Vesicles Trigger Hearing Loss: The Role of Pyroptosis in Cochlear Damage

Xu, T.; Zhang, J.; Zhao, H.; Nong, H.; Yang, Q.; Yuan, Y.; Zhao, J.; Zhang, X.; Li, Y.; Tun, Z. M. M.; Bekale, L.; Cao, Z.

10.1101/2025.04.28.650954 — immunology — Posted on 2025-05-07

4810 Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function

Devlin, B.; Nguyen, D.; Ribeiro, D.; Grullon, G.; Clark, M.; Finn, A.; Ceasrine, A. M.; Oxendine, S.; Deja, M.; Shah, A.; Ati, S.; Schaefer, A.; Bilbo, S. D.

10.1101/2024.05.10.589920 — neuroscience — Posted on 2025-05-07

4811 DateBack, an evolving open-access repository of Phoenix archaeobotanical data supporting new perspectives on the history of date palm cultivation

Besseiche, M.; Chambraud, E.; Dabrowski, V.; Brandstatt, E.; Sabot, F.; Bouchaud, C.; Gros-Balthazard, M.

10.1101/2025.02.21.639487 — evolutionary biology — Posted on 2025-05-07

4812 A molecular circuit regulates fate plasticity in emerging and adult AT2 cells

Sawhney, A. S.; Deskin, B. J.; Cai, J.; Gibbard, D.; Ali, G.; Utoft, A.; Qi, X.; Olson, A.; Hausman, H.; Sabol, L.; Holmberg, S.; Shah, R.; Warren, R.; De Langhe, S. P. J.; Benedito, R.; Inde, Z.; Sarosiek, K.; Lemire, E.; Haber, A. L.; Wang, L.; Wei, Z.; Brownfield, D. G.

10.1101/2025.04.28.650846 — developmental biology — Posted on 2025-05-07

4813 Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently from mesothelial fate.

Alsukari, S. H.; Ng, H. T.; Lang, L.; Lunn, S.; Beglinger, S.; Carr, L.; Boyes, M.; Turner, D. A.; Wilm, B.

10.1101/2024.08.08.607207 — developmental biology — Posted on 2025-05-07

4814 Large Reaching Datasets Quantify the Impact of Age, Sex/Gender, and Experience on Motor Control

Zhang, A.; Ruitenberg, M.; Warburton, M.; Scott, S.; Tsay, J. S.

10.1101/2025.05.01.651757 — neuroscience — Posted on 2025-05-07

4815 Identification and Overexpression of Endogenous Transcription Factors to Enhance Lipid Accumulation in the Commercially Relevant Species Chlamydomonas pacifica

Gupta, A.; Oliver, A.; Molino, J. V. D.; Wnuk-Fink, K. M.; Tessman, M.; Kang, K.; Santo, E. d. E.; Torres-Tiji, Y.; Burkart, M.; Mayfield, S.

10.1101/2025.05.01.651737 — systems biology — Posted on 2025-05-07

4816 Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

Irie, K.; Phillip, M.; Reifenberg, J.; Brendan, B. M.; Noe, J. D.; Jeffrey, H.; Mizuno, T.

10.1101/2025.05.01.651780 — pharmacology and toxicology — Posted on 2025-05-07

4817 Endothelial AGO1 Drives Vascular Inflammation and Atherosclerosis via a Non-Canonical Nuclear Mechanism

Liu, X.; Yuan, D.; Luo, Y.; Tang, X.; Tapia, A.; Malhi, N. K.; Chadha, R. S.; Tiwari, S.; Swiderski, P.; Wang, K.-C.; Kortylewski, M.; Pardi, N.; Wei, L.; Huang, W.; Chen, Z. B.

10.1101/2025.05.01.651783 — pathology — Posted on 2025-05-07

4818 IRE1α and IRE1β Protect Intestinal Epithelium and Suppress Colorectal Tumorigenesis through Distinct Mechanisms

Deng, R.; Wang, M.; Promlek, T.; Druelle-Cedano, C.; Murad, R.; Davidson, N. O.; Kaufman, R. J.

10.1101/2025.05.01.651751 — cancer biology — Posted on 2025-05-07

4819 HUGMi: Human Uro-Genital Microbiome database and hybrid classifier for improved species level annotation of 16S rRNA amplicon sequences

Bhowmik, D.; Paul, S.

10.1101/2025.05.01.651608 — bioinformatics — Posted on 2025-05-07

4820 A Gentle Introduction to Spatial Transcriptomic Analysis with 10X Visium Data

Gillespie, J.; Xie, J.; Jung, K. J.; Hardiman, G.; Pietrzak, M.; Chung, D.

10.1101/2025.05.01.651786 — bioinformatics — Posted on 2025-05-07

4821 Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain

Kong, D.; He, H.; Lechner, J.; Yang, J.; Zhang, A.; li, L.; Mathur, R.; Darland, D.; Takaku, M.; Lu, L.; Peng, J.; Yang, K.; Wang, X.

10.1101/2025.05.01.651759 — bioinformatics — Posted on 2025-05-07

4822 Antibody-Based Targeting of the SPP1-CD44 Axis in Pediatric High-Grade Glioma through Single-Cell and Structural Bioinformatics

Limbu, S.; Kumar, A.

10.1101/2025.05.01.651763 — bioinformatics — Posted on 2025-05-07

4823 Microglia modulate concussion biomarkers and cognitive recovery in male mice

Anderson, E. D.; Augustin, D.; Georges, A. P.; Kim, T.; Issadore, D. A.; Meaney, D. F.

10.1101/2025.05.01.651070 — bioengineering — Posted on 2025-05-07

4824 Chromosome-level genome assembly of the photobiont alga Trebouxia sp. 'A48' from Xanthoria parietina provides new insight into the lichen symbiosis

Tagirdzhanova, G.; Raistrick, J.; Talbot, N. J.

10.1101/2025.05.01.651714 — genomics — Posted on 2025-05-07

4825 First-trimester exposure to anti-cytomegalovirus medications: a study of the effects of valaciclovir, letermovir and maribavir on early placental development

Atukorala, I.; de Alwis, N.; Beard, S.; Raghavan, S.; Hannan, N. J.; Hui, L.

10.1101/2025.05.01.651765 — developmental biology — Posted on 2025-05-07

4826 Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish

Chen, Z. Z.; Narayanan, S. N.; Stagliano, L. M.; Huynh, P. Q.; Sundaram, S.; Mackey, E. J.; Miller, C. T.; Square, T. A.

10.1101/2025.05.01.651241 — developmental biology — Posted on 2025-05-07

4827 Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis

Shin, A.; Jensen, N.; Butt, E.; An, J.; Pham-Howard, D.; Galambos, L.; Mathieson, K.; Kamins, T.; Palanker, D.

10.1101/2025.05.01.651774 — neuroscience — Posted on 2025-05-07

4828 EMMAi: fast enzyme-allocation constraints in GEMs for improved biomass prediction across carbon sources

Molina Ortiz, J. P.; Benson, D.; Watts, J.; Velasque, M.; Warden, A.; Morgan, M.

10.1101/2025.05.01.651607 — systems biology — Posted on 2025-05-07

4829 Automated Quantitative Assessment of Elastic Fibers in Verhoeff-Van Gieson-Stained Mouse Aorta Histological Images

Lefebvre, A. E. Y. T.-S.; Mullis, M.

10.1101/2025.05.01.651802 — pathology — Posted on 2025-05-07

4830 Learning the Shape of Evolutionary Landscapes: Geometric Deep Learning Reveals Hidden Structure in Phenotype-to-Fitness Maps

Razo-Mejia, M.; Mani, M.; Petrov, D. A.

10.1101/2025.05.07.652616 — evolutionary biology — Posted on 2025-05-07

4831 Visual lateralisation in female guppies demonstrates social conformity but is reduced when observing a live predator

Penry-Williams, I. L.; Brown, C.; Ioannou, C. C.

10.1101/2025.05.06.652411 — animal behavior and cognition — Posted on 2025-05-07

4832 A high-resolution, country-wide scenario analysis of forest susceptibility to spruce bark beetle damage in Norway

Cattaneo, N.; Krokene, P.; Astrup, R.

10.1101/2025.05.06.652523 — ecology — Posted on 2025-05-07

4833 Pearling Drives Mitochondrial DNA Nucleoid Distribution

Landoni, J. C.; Lycas, M. D.; Macuada, J.; Stepp, W.; Jaccard, R.; Obara, C. J.; Moore, A. S.; Hoffman, D.; Lippincott-Schwartz, J.; Marshall, W.; Sturm, G.; Manley, S.

10.1101/2024.12.21.629917 — cell biology — Posted on 2025-05-07

4834 Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips

Stejskalova, A.; Calderon, K.; Chou, D. B.; Gulati, A.; Feitor, J. F.; Izadifar, Z.; Gutzeit, O.; Bouchibti, Y.; Chen, S.; Plebani, R.; Cotton, J.; Hughes, J. G.; Ferrante, T.; Budnik, B.; Goyal, G.; Junaid, A.; Lebrilla, C. B.; Ingber, D. E.

10.1101/2025.05.01.651107 — bioengineering — Posted on 2025-05-07

4835 Evolution of β-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae

Petersen, S.; Diricks, M.; Utpatel, C.; Schulenburg, H.; Merker, M.

10.1101/2025.05.02.651845 — genomics — Posted on 2025-05-07

4836 Genome structure mapping with high-resolution 3D genomics and deep learning

Hong, C. K. Y.; Feng, F.; Ramanathan, V.; Liu, J.; Hansen, A. S.

10.1101/2025.05.06.650874 — genomics — Posted on 2025-05-07

4837 Cell cycle controls pathogenic processes and mycotoxin production in Fusarium graminearum

Svoboda, T.; Zsiros, C.; Kastner, F.; Sulyok, M.; Strauss, J.

10.1101/2025.05.01.651613 — genetics — Posted on 2025-05-07

4838 Mating Type Gene Divergence is Associated with Life Cycle Differentiation in Scots Pine Blister Rust

Gomez-Zapata, P. A.; Tellgren-Roth, C.; Samils, B.; Stenlid, J.; Kaitera, J.; Brandstrom Durling, M.; Seidl, M. F.; Olson, A.

10.1101/2025.05.02.651906 — evolutionary biology — Posted on 2025-05-07

4839 Alternative reproductive strategies explain asymmetric reinforcement of reproductive isolation in two Ischnura damselfly species

Ordaz-Morales, J. E.; Juarez-Jimenez, A. L.; Stand-Perez, M.; Arce-Valdes, L. R.; Ballen-Guapacha, A. V.; Chavez-Rios, J. R.; Cordero-Rivera, A.; Sanchez-Guillen, R. A.

10.1101/2025.05.04.652146 — evolutionary biology — Posted on 2025-05-07

4840 A method for massively scalable phylogenetic network inference

Kolbow, N.; Kong, S.; Solis-Lemus, C.

10.1101/2025.05.05.652278 — evolutionary biology — Posted on 2025-05-07

4841 Macrophage Migration Inhibitory Factor Suppresses Natural Killer Cell Response and Promotes Hypoimmunogenic Stem Cell Engraftment Following Spinal Cord Injury

Li, S.; Zheng, Y.; Xue, H.; Zhang, H.; Wu, J.; Chen, X.; Perez Bouza, M.; Yi, S.; Zhou, H.; Xia, X.; Zeng, X.; Cao, Q. L.; Liu, Y.

10.1101/2025.05.06.652516 — cell biology — Posted on 2025-05-07

4842 A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes

Watanabe, Y. V.; Sussman, J. H.; Anami, T.; Hattori, M.; Yamane, S.; Nishikawa, M.; Sakai, Y.; Katsuda, T.

10.1101/2025.05.07.652591 — cell biology — Posted on 2025-05-07

4843 Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 foci

Wu, C.; Manjarrez-Gonzalez, J. C.; Choudhury, M. S.; Shamkhi, N.; Ding, S.; Nair, V. M.; Draviam, V. M.

10.1101/2025.05.07.652606 — cell biology — Posted on 2025-05-07

4844 Phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages

Cheng, H. Y.; Chu, J.; Limjunyawong, N.; Chen, J.; Ye, Y.; Chen, K. H.; Koylass, N.; Sun, S.; Dong, X.; Qiu, Z.

10.1101/2025.02.27.640612 — immunology — Posted on 2025-05-07

4845 Decoding of frequency modulated sweeps by core and belt neurons in the alert macaque auditory cortex.

Malone, B. J.; Recanzone, G. H.

10.1101/2025.04.30.651560 — neuroscience — Posted on 2025-05-07

4846 Caspase cleavage of APP contributes to amyloid beta-protein induced synaptic injury

Park, G.

10.1101/2025.04.30.651606 — neuroscience — Posted on 2025-05-07

4847 PW-GAN: Pseudo-Warping Field Guided GAN for Unsupervised Denoising of Fetal Brain MRI Images

Chen, L.; Lin, J.; Fu, G.; Yang, P.; Liu, M.

10.1101/2025.04.30.651598 — neuroscience — Posted on 2025-05-07

4848 Acute Administration of Oxytocin in the Functional Recovery of Neurocognitive and Social Deficits Following Juvenile Frontal Traumatic Brain Injury

Shonka, S.; Ford, C.; Hylin, M. J.

10.1101/2025.04.30.651517 — neuroscience — Posted on 2025-05-07

4849 Discover the Maze-like Pathway for Glabridin Biosynthesis

Zhang, Z.; Li, W.; Meng, F.; Jin, Y.; Sun, W.; Kuang, Q.; Ren, S.; Liu, W.; Zhang, L.; Qin, L.; Lv, B.; Jia, H.; Li, C.

10.1101/2025.05.06.652391 — synthetic biology — Posted on 2025-05-07

4850 Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves

Fujii, Y.; Taira, S.; Shinoda, K.; Yamato, Y.; Sakata, K.; Muta, O.; Osada, Y.; Ono, A.; Matsushita, T.; Azumi, M.; Shikano, H.; Abe, K.; Calabrese, V.; Osakabe, N.

10.1101/2025.05.06.652378 — synthetic biology — Posted on 2025-05-07

4851 Design of overlapping genes using deep generative models of protein sequences

Byeon, G. W.; Exposit, M.; Baker, D.; Seelig, G.

10.1101/2025.05.06.652464 — synthetic biology — Posted on 2025-05-07

4852 A synthetic biology toolkit for interrogating plasmid-dependent methylotrophy and enhancing methanol-based biosynthesis of Bacillus methanolicus

Liu, P.; Yuan, Q.; Yang, X.; Wang, Q.; Chang, T.; Bi, Y.; Wu, P.; Zhang, T.; Yang, J.; Guo, S.; Xue, C.; Zheng, Z.; Xin, B.; Ma, H.; Wang, Y.

10.1101/2025.05.06.652373 — synthetic biology — Posted on 2025-05-07

4853 MONOPTEROS isoform MP11ir role during somatic embryogenesis in Arabidopsis thaliana

Wojcikowska, B.; Belaidi, S.; Mironova, V.; Citerne, S.; Robert, H. S.

10.1101/2024.07.17.603838 — plant biology — Posted on 2025-05-07

4854 Xenon Explores Apparent and Cryptic Binding Sites

Iida, S.

10.1101/2025.04.30.651394 — biophysics — Posted on 2025-05-07

4855 Fetal Health Classification Based on CTG

Madiraju, R.; Upadhyay, U.; C, M.

10.1101/2025.05.01.651406 — bioengineering — Posted on 2025-05-07

4856 Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy

Zamat, A.; Kim, C.; Sridhar, S.; Fabrega, S.; Sen, R.; Campbell, N.; Oliver, S. A.; Zha, Z.; Thiveaud, C.; Kulaksizoglu, E.; Brienen, M.; Okada, H.; Woodworth, G.; Arvanitis, C.; Kwong, G. A.

10.1101/2025.04.23.650339 — bioengineering — Posted on 2025-05-07

4857 A Preclinical Alcohol BioBank: Samples from Behaviorally Characterized HS Rats for AUD Research

Doyle, M. R.; Campo, P.; Dirik, S.; Balaguer, M.; Martinez, A. R.; Kallupi, M.; de Guglielmo, G.

10.1101/2025.04.30.651600 — animal behavior and cognition — Posted on 2025-05-07

4858 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)

Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.

10.1101/2024.12.06.627158 — genomics — Posted on 2025-05-07

4859 Range-wide responses to an extreme heat event in Mimulus cardinalis

Albano, L. J.; Bingham, R. A.; Correa, S.; Laufenberg, C. G.; Payst, C.; Muir, C. D.; Sheth, S. N.

10.1101/2025.05.01.651703 — evolutionary biology — Posted on 2025-05-07

4860 Local adaptation in a metapopulation - a multi-habitat perspective

Olusanya, O.; Barton, N. H.; Polechova, J.

10.1101/2025.05.03.652039 — evolutionary biology — Posted on 2025-05-07

4861 Evolutionary Analysis of Gene-expression Localization in the Model Crustacean, Daphnia pulex

Ye, Z.; Swenty, T.; Zelhof, A. C.; Lynch, M.

10.1101/2025.05.01.651673 — evolutionary biology — Posted on 2025-05-07

4862 Evolutionary Influences on Local Patterns of Genetic Relatedness

Smith, T. Q.; Rahman, A.; Schaeffer, S. W.; Szpiech, Z. A.

10.1101/2025.05.02.651970 — evolutionary biology — Posted on 2025-05-07

4863 Multiple mating predicts queen reproductive output in the polygynous Neotropical trap-jaw ant, Odontomachus chelifer (Formicidae: Ponerinae)

Florindo, H. S.; Azevedo-Silva, M.; Romeiro, M.; Pereira de Souza, A.; Oliveira, P. S.; Mori, G. M.

10.1101/2025.05.05.652256 — evolutionary biology — Posted on 2025-05-07

4864 Longitudinal and cross-sectional selection on flowering traits in a self-incompatible annual.

Leventhal, L.; Bai, K. J.; Peters, M. A. E.; Austen, E. J.; Weis, A. E.; Ison, J. L.

10.1101/2025.04.30.651553 — evolutionary biology — Posted on 2025-05-07

4865 Predation, evo-devo, and historical contingency: A nematode predator drives evolution of aggregative multicellularity

Schaal, K. A.; La Fortezza, M.; Velicer, G. J.

10.1101/2025.05.04.652091 — evolutionary biology — Posted on 2025-05-07

4866 PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

Druker, J.; Jiang, H.; Shakir, D.; Child, F.; Alvarez, V.; Platani, M.; Corno, A.; Alabert, C.; Saurin, A. T.; Swedlow, J. R.; Rocha, S.; Lamond, A. I.

10.1101/2025.05.06.652400 — cell biology — Posted on 2025-05-07

4867 Efficacy of vocal cord injection of dedifferentiated fat cells in treating glottis closure insufficiency: Insights from a rat model of recurrent laryngeal nerve resection

Mikoshiba, I.; Hagikura, K.; Matsumoto, T.; Kazama, T.; Asai, R.; Hao, H.; Oshima, T.

10.1101/2025.05.06.652489 — cell biology — Posted on 2025-05-07

4868 Endothelial β-PIX (ARHGEF7) drives exocytosis through enabling the dynamic reorganisation of the cytoskeleton

El-Mansi, S.; Deegan, K. M.; Donker, L.; Godinho, S.; Nightingale, T. D.

10.1101/2025.05.06.652370 — cell biology — Posted on 2025-05-07

4869 Class I myosins direct circumferential F-actin flows to define cell chirality

Yamaguchi, A.; Sasamura, T.; Haraguchi, T.; Yoshimura, K.; Taniguchi, H.; Kurisu, D.; Akano, Y.; Higashi, T.; Sato, Y.; Neugebauer, F. L.; Inaki, M.; Inoue, Y.; Akiyama, M.; Ito, K.; Matsuno, K.

10.1101/2025.05.06.648335 — cell biology — Posted on 2025-05-07

4870 BLADE-R: streamlined RNA extraction for molecular diagnostics and high-throughput applications

Tajammal, A.; Haddox, S.; Zahra, S.; Cornelison, R.; Fierti, A. O.; Li, H.

10.1101/2025.03.27.645479 — molecular biology — Posted on 2025-05-07

4871 Hidden Diversity in Enterococcus faecalis Revealed by CRISPR2 Screening: Eco-evolutionary Insights into a Novel Subspecies

Leite, V.; Faria, A. R.; Guerra, C.; Souza, S. S. R.; Freitas, A. A. R.; Morais, J.; Merquior, V. L. C.; Planet, P. J.; Teixeira, L. M.

10.1101/2025.05.05.652174 — microbiology — Posted on 2025-05-07

4872 The cellular mammalian clock regulates Staphylococcus aureus invasion in epithelial cells

Agarwal, P.; Chandrasekharan, G.; Grewal, J.; Dallmann, R.; Unnikrishnan, M.

10.1101/2025.05.05.652254 — microbiology — Posted on 2025-05-07

4873 Genetic modification of Clostridium kluyveri for heterologous n-butanol and n-hexanol production

Schlaiss, C.; Baur, S. T.; Marsh, J. W.; Gemeinhardt, K.; Angenent, L. T.

10.1101/2025.05.05.652178 — microbiology — Posted on 2025-05-07

4874 Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy

Zborowsky, S.; Seurat, J.; Balacheff, Q.; Ecomard, S.; Mulet, C.; Minh, C. N. N.; Titecat, M.; Evrard, E.; Rodriguez-Gonzalez, R. A.; Marchi, J.; Weitz, J. S.; Debarbieux, L.

10.1101/2024.01.16.575879 — microbiology — Posted on 2025-05-07

4875 Endospore Appendages Enhance Bacillus cereus Spore Adhesion to Industrial Surfaces, Modulated by Physicochemical Factors

Albertsdottir Jonsmoen, U. L.; Aspholm, M. E.; Malyshev, D.; Allred, J. A.; Segervald, J.; Andersson, M.

10.1101/2025.05.06.652425 — microbiology — Posted on 2025-05-07

4876 Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance

Chen, X.; Pan, D.; Liu, J.-J.; Yang, Y.

10.1101/2024.09.07.611815 — neuroscience — Posted on 2025-05-07

4877 Capturing individual variation in children's oscillatory brain activity during nREM sleep

Heikkinen, V.; Merz, S.; Salmelin, R.; Vanhatalo, S.; Lauronen, L.; Liljestrom, M.; Renvall, H.

10.1101/2025.05.02.651817 — neuroscience — Posted on 2025-05-07

4878 Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

Libera, J. L.; Hu, J.; Nguyen, T.-A.; Wang, Z.; van der Spek, S. J. F.; Schult, K.; Dorrian, L.; Majka, J.; Tobunluepop, K.; Puri, S.; Kynshov, A.; Kanaan, N. M.; Nelson, P. T.; Meyer, K.; Hou, L.; Zhang, X.; Wolozin, B.

10.1101/2025.05.02.651974 — neuroscience — Posted on 2025-05-07

4879 Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

Farnworth, M. S.; Toh, Y. P.; Loupasaki, T.; Hodge, E. A.; el Jundi, B.; Montgomery, S. H.

10.1101/2025.05.02.651904 — neuroscience — Posted on 2025-05-07

4880 Photocaged FLP Recombinase for Precise Spatio-temporal Control of Gene Expression

Rodriguez, J. J. V.; Baxter, K.; Greiss, S.

10.1101/2025.05.06.652468 — synthetic biology — Posted on 2025-05-07

4881 Rhythms of Early Life: Gut Microbiota Rhythmicity and Circadian Maturation in infants

Muehlematter, C.; Nielsen, D. S.; Castro-Mejia, J.; Walser, J.-C.; Schoch, S.; Kurth, S.

10.1101/2025.01.06.631487 — physiology — Posted on 2025-05-07

4882 Oncostratifier: Stratifying Oncogene-addicted Cohorts By Drug Response

Tepeli, Y. I.; Trastulla, L.; Goncalves, J. P.; Iorio, F.

10.1101/2025.05.01.650955 — cancer biology — Posted on 2025-05-07

4883 Millisecond bidirectional protein translocation by a AAA+ disaggregation machine

Casier, R.; Levy, D.; Riven, I.; Barak, Y.; Haran, G.

10.1101/2025.03.13.643017 — biophysics — Posted on 2025-05-07

4884 Accurate and Reproducible Whole-Genome Genotyping for Bacterial Genomic Surveillance with Nanopore Sequencing Data

Prior, K.; Becker, K.; Brandt, C.; Cabal Rosel, A.; Dabernig-Heinz, J.; Kohler, C.; Lohde, M.; Ruppitsch, W.; Schuler, F.; Wagner, G. E.; Mellmann, A.

10.1101/2025.02.24.639834 — bioinformatics — Posted on 2025-05-07

4885 Deciphering epigenetic influence of curcumin on histone signatures in breast cancer using 3D network

Tang, T.; Berezin, M. Y.; Garcia, B. A.; Mollah, S. A.

10.1101/2024.11.13.623008 — bioinformatics — Posted on 2025-05-07

4886 Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations

Li, B.; Xing, Y.; Zhou, Y.; Xiao, X.; Shu, T.; Song, X.; Zhao, H.; Wang, X.-J.; Pang, J.; Yang, P.; Wang, J.; Yu, P. B.; Wang, C.

10.1101/2025.04.30.651587 — bioinformatics — Posted on 2025-05-07

4887 Combined optical coherence tomography and electroretinography (OCT+ERG) system for imaging neurovascular coupling in the human retina

Dhaliwal, K. K.; Wong, A.; Wright, T.; Bizheva, K.

10.1101/2025.03.27.643714 — bioengineering — Posted on 2025-05-07

4888 Mechanisms Underlying Allosteric Modulation of Antiseizure Medication Binding to Synaptic Vesicle Protein 2A (SV2A)

Mittal, A.; Martin, M. F.; Provins, L.; Hall, A.; Ledecq, M.; Wolff, C.; Gillard, M.; Horanyi, P. S.; Coleman, J. A.

10.1101/2025.05.05.652227 — biochemistry — Posted on 2025-05-07

4889 Red deer individual landscapes of fear in response to human recreation.

Boehme, B.; Peters, A.; Mitterwallner, V.; Sommer, F.; Heurich, M.; Hertel, A. G.

10.1101/2024.06.20.599860 — animal behavior and cognition — Posted on 2025-05-07

4890 Seasonal variation in insect assemblages at flowers of Balanites aegyptiaca, an ecologically and socially important tree species in the Ferlo region of Senegal's Great Green Wall corridor

MEDINA-SERRANO, N.; Bagneres, A.-G.; Ndiaye, M. M.; Vrecko, V.; McKey, D.; Hossaert, M.

10.1101/2025.03.26.645493 — ecology — Posted on 2025-05-07

4891 Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

Wu, Y.; Guo, W.; Kuang, H.; Wu, X.; Trinh, T. H.; Wang, Y.; Zhao, S.; Wen, Z.; Yu, T.

10.1101/2023.12.14.570333 — developmental biology — Posted on 2025-05-07

4892 A Critical Role for the Fascin Family of Actin Bundling Proteins in Axon Development, Brain Wiring and Function

Hardin, K. R.; Penas, A.; Joubert, S.; Ye, C.; Myers, K. R.; Zheng, J.

10.1101/2025.02.21.639554 — cell biology — Posted on 2025-05-07

4893 Molecular basis for the regulation of retroviral nucleosomal integration by chromatin compaction

Lapaillerie, D.; Zgadzayy, Y.; Martins, F. G.; Bertinetti, C.; Autin, M.; Batisse, J.; Tumiotto, C.; Paul, L.; Ruff, M.; Sousa, S.; Parissi, V.

10.1101/2025.05.05.652197 — microbiology — Posted on 2025-05-07

4894 Opposing, multiplexed information in lateral and ventral orbitofrontal cortex guides sequential foraging decisions in rats

Cunningham, P. J.; Redish, A. D.

10.1101/2024.08.17.608409 — neuroscience — Posted on 2025-05-07

4895 Online versus Cognitive Control: A Dividing Line between Physical Action and Motor Imagery

Martel, M.; Glover, S.

10.1101/2022.10.31.514494 — neuroscience — Posted on 2025-05-07

4896 Phase-precession-like Effect in the Anterior Insula Cortex during Reward Expectancy

Yang, L.; Lehongre, K.; Ye, H.; Yu, X.; Navarro, V.; Cheng, S.; Axmacher, N.; Wang, S.; Zhang, H.

10.1101/2023.09.19.558205 — neuroscience — Posted on 2025-05-07

4897 FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy

Menon, S.; Gracilla, D.; Breese, M. R.; Lin, Y. P.; Dela Cruz, F. S.; Feinberg, T.; De Stanchina, E.; Galic, A.-F.; Allegakoen, H.; perati, s.; Wen, N.; Heslin, A.; Horlbeck, M.; Weissman, J. S.; Sweet-Cordero, A.; Bivona, T.; Tulpule, A.

10.1101/2023.04.30.538578 — cancer biology — Posted on 2025-05-07

4898 The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging

Li, H.-F.; Dong, B.; Peng, Y.-Y.; Luo, H.-Y.; Ou, X.-L.; Ren, Z.-L.; Park, Y.; Wang, J.-J.; Jiang, H.-B.

10.1101/2024.07.30.605941 — ecology — Posted on 2025-05-07

4899 Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-kB and p53 perturbation

Maduka, C. V.; Xie, X.; Makela, A. V.; Ural, E.; Contag, C. H.

10.1101/2025.04.30.651567 — immunology — Posted on 2025-05-07

4900 BRG1 targeting overcomes ABCC-based multidrug resistance induced by paclitaxel

Gronkowska, K.; Michlewska, S.; Ploszaj, T.; Strachowska, M.; Stepien, A.; Borowiec, M.; Bednarek, A.; Robaszkiewicz, A.

10.1101/2025.05.01.651609 — cancer biology — Posted on 2025-05-07

4901 Identify Alzheimer's disease subtypes and makers from multi-omic data of human brain and blood with a subspace merging algorithm

Song, Z.; Huang, X.; Jannu, A. J.; Johnson, T. S.; Zhang, J.; Huang, K.

10.1101/2025.04.30.651565 — bioinformatics — Posted on 2025-05-07

4902 An automated software-assisted approach for exploring metabolic susceptibility and degradation products in macromolecules using High-Resolution Mass Spectrometry

Cifuentes Lopez, P.; Zamora, I.; Radchenko, T.; Fontaine, F.; Garriga, A.; Moretonni, L.; Kammersgaard Christensen, J.; Helleberg, H.; A. Becker, B.

10.1101/2025.05.01.651614 — bioinformatics — Posted on 2025-05-07

4903 Democratizing Organ-on-Chip Technologies with a Modular, Reusable, and Perfusion-Ready Microphysiological System

Minahan, D. J.; Nelson, K. M.; Ribeiro, F.; Ferrick, B. J.; Zurzolo, A. M.; Byers, K.; Gleghorn, J. P.

10.1101/2025.04.30.651503 — bioengineering — Posted on 2025-05-07

4904 3D Printed Nerve Guidance Conduit for Biologics-Free Nerve Regeneration and Vascular Integration

Schimelman, J.; Berry, D. B.; Johnson, S.; Shi, R.; Brown, S.; Nguyen, Q. T.; Chen, S.

10.1101/2025.04.30.651603 — bioengineering — Posted on 2025-05-07

4905 Unraveling forensic timelines using molecular markers in Phormia regina maggots

Lin, S.-H.; Bellantuono, A. J.; Lopez, K.; Wells, J. D.; DeGennaro, M.

10.1101/2025.04.30.651557 — developmental biology — Posted on 2025-05-07

4906 Clonal analysis reveals differential PGC contributions to the early germline and ovarian reserve

Pahima, M.; Marlow, F.

10.1101/2025.04.30.651497 — developmental biology — Posted on 2025-05-07

4907 Oocyte exposure to low levels of triclosan has a significant impact on subsequent embryo physiology.

Papachristofi, V.; McKeegan, P. J.; Leese, H. J.; Rotchell, J.; Sturmey, R. G.

10.1101/2025.05.01.651623 — developmental biology — Posted on 2025-05-07

4908 Cytohesin-2 is essential for the survival of mice and regulates Golgi volume and function

Kuesters, C.; Jux, B.; Shakeri, F.; Kallabis, S.; Meissner, F.; Prof. Kolanus, W.

10.1101/2025.05.05.651226 — cell biology — Posted on 2025-05-07

4909 The complexity of multiple CRISPR arrays in strains with (co-occurring) CRISPR systems

Fehrenbach, A.; Mitrofanov, A.; Backofen, R.; Baumdicker, F.

10.1101/2025.05.05.651427 — microbiology — Posted on 2025-05-07

4910 Cover crop root channels promote bacterial adaptation to drought in the maize rhizosphere

Ghosh, D.; Shi, Y.; Zimmermann, I. M.; Holzhauser, K.; Bergen, M. v.; Kaster, A.-K.; Spielvogel, S.; Dippold, M. A.; Mueller, J. A.; Jehmlich, N.

10.1101/2025.05.05.651044 — microbiology — Posted on 2025-05-07

4911 Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cells dysfunction in human cancer

Ward, C. J.; Chakraborty, S.; Shaji, S. K.; Veiga-Villauriz, C.; Zhao, Q.; Chen, X.; Mahata, B.

10.1101/2025.04.30.651472 — immunology — Posted on 2025-05-07

4912 Cellular and Regional Vulnerability Shapes the Molecular Landscape of Psychosis in Alzheimers Disease

Victor, M. B.; Sun, N.; Galani, K.; Leary, N.; Tanigawa, Y.; Scannail, A. N.; Ho, L.-L.; Prosper, S.; Liu, L.; Kofler, J. K.; Sweet, R.; Tsai, L.-H.; Kellis, M.

10.1101/2025.04.30.651435 — neuroscience — Posted on 2025-05-07

4913 Identification of a RIPK2-Regulated Gene Signature as a Candidate Biomarker for RIPK2 Activity and Prognosis in Prostate Cancer

Elgehama, A. M.; Yang, Q.; He, Z.; Ruegg, L. E.; You, S.; Yang, W.

10.1101/2025.04.30.651490 — cancer biology — Posted on 2025-05-07

4914 Incorporating LLM-Derived Information into Hypothesis Testing for Genomics Applications

Bryan, J. G.; Niu, H.; Li, D.

10.1101/2025.04.30.651464 — bioinformatics — Posted on 2025-05-07

4915 Benchmarking of Quantum SVM and Classical ML Algorithms for Prediction of Therapeutic Proteins

Tijare, P.; Mehta, N. K.; Raghava, G. P. S.

10.1101/2025.04.30.651419 — bioinformatics — Posted on 2025-05-07

4916 AF2Rank Revisited: Reproducing AlphaFold-Based Structure Evaluation and a Hypothesis for Context-Aware Refinement (CAR-AF)

Kumar, P.

10.1101/2025.04.30.651434 — bioinformatics — Posted on 2025-05-07

4917 Sequencing and functional analysis of Sphingobium yanoikuyae A-TP genome reveals genes for utilization of limonene, α-pinene, and citronellol

Jankovic, N.; Marques de Castro, G.; Quintanilha Torres, A. L.; Chelala Moreira, R.; Uliano-Silva, M.; Souza da Conceicao, C.; Lima Coelho, V.; Alves Americo, J.; Lemos Bicas, J.; de Freitas Rebelo, M.

10.1101/2025.04.30.651573 — genomics — Posted on 2025-05-07

4918 Adapter dilution and input optimisation for Qiagen QIAseq miRNA Library kit

Hasby, F.; Bachmann, J. A.; Wang, C.; Contreras-Lopez, O.; Mezger, A.

10.1101/2025.04.30.651388 — genomics — Posted on 2025-05-07

4919 Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes

Sadri, G.; Nadakal, S. T.; Lauer, W. A.; Kos, J.; Singh, P.; Elliott, E. M.; Kaiser, C.; Ford, E. E.; Richardson, N.; Hudson, E.; Linden, N.; Danesh, A.; Powell, J.; Warburton, P.; Soto, J.; Emery, M.; Deikus, G.; Lee, G. Q.; Lamers, S.; Reynolds, S. J.; Galiwango, R. M.; Prodger, J. L.; Tomusange, S.; Kityamuweesi, T.; Han, T.; Jones, R. B.; Tobian, A. A. R.; Engelman, A. N.; Sebra, R.; Morgello, S.; Redd, A. D.; Sachs, D.; Rouchka, E.; Smith, M. L.

10.1101/2025.05.01.651657 — genomics — Posted on 2025-05-07

4920 Emergence Risks from Within? Metagenomic Analysis of Mosquito Viromes from Two Zoos Reveals Mosquito-associated Orthobunyaviruses in the UK

Pilgrim, J.; Seechurn, N.; Cunningham-Oakes, E.; Dobbs, P.; Lopez, J.; Kohl, A.; Hughes, G. L.; Blagrove, M. S.; Baylis, M.; Darby, A. C.

10.1101/2025.05.01.651672 — genomics — Posted on 2025-05-07

4921 The Evolutionary Landscape of tRNA Modifications in Archaea: Insights from High-Throughput Sequencing

Leavitt, J. S.; Moore, H.; Santangelo, T. J.; Lowe, T. M.

10.1101/2025.05.02.651894 — evolutionary biology — Posted on 2025-05-07

4922 Analysis of duplication and possible sub-functionalization of wing gene network components in pea aphids

Ziabari, O. S.; Deem, K. D.; Zhong, Q.; Brisson, J. A.

10.1101/2025.04.30.651519 — evolutionary biology — Posted on 2025-05-07

4923 Neonatal infection with Helicobacter pylori affects stomach and colon microbiome composition and gene expression in mice

Graversen, K. B.; Bjarnov-Nicolau, B.; Klove, S.; Halajova, K.; Andersen, S. B.

10.1101/2025.04.30.650706 — evolutionary biology — Posted on 2025-05-07

4924 CRISPR-Cas9 HDR Optimization: RAD52, Denatured and 5'-Modified DNA Templates in Knock-In Mice Generation

Skryabin, B. V.; Braun, D. A.; Kaiser, H.; Gubar, L.; Seeger, B.; Khanam, T.; Stegemann, A.; Pavenstädt, H.; Rozhdestvensky, T. S.

10.1101/2025.05.05.652162 — molecular biology — Posted on 2025-05-07

4925 Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models

Goddard, P.; Tzelos, T.; Colon, B. L.; Bartley, P.; Robinson, L.; Lemgruber, L.; Tinti, M.; Hall, G. M.; Stevens, S.; Gibbard, L.; Bernard, R.; Tytler, G.; Smith, D.; Katzer, F.; Pawlowic, M. C.

10.1101/2025.05.05.652177 — microbiology — Posted on 2025-05-07

4926 A novel approach to map the causal impact of brain stimulation on semantic processing with language models

Bruera, A.; Hartwigsen, G.

10.1101/2025.05.06.652092 — neuroscience — Posted on 2025-05-07

4927 Revisiting atypical language lateralization in dyslexia

Verhelst, H.; Karlsson, E. M.; Gerrits, R.; Vingerhoets, G.

10.1101/2025.05.06.652381 — neuroscience — Posted on 2025-05-07

4928 Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus.

Nguyen, V. D.; Bright, M.; Zhou, Y.; Morgan, B. P.; Zelek, W. M.

10.1101/2025.05.06.652374 — neuroscience — Posted on 2025-05-07

4929 Neural and behavioral signatures of policy compression in cognitive control

Liu, S.; Kikumoto, A.; Badre, D.; Gershman, S. J.

10.1101/2025.05.06.652533 — neuroscience — Posted on 2025-05-07

4930 Loss of age-associated increase in mA-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

10.1101/2025.05.02.651974 — neuroscience — Posted on 2025-05-07

4931 Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets

Hansen, M. S.; Hill, C. J.; Sussel, L.; Wells, K. L.

10.1101/2025.04.30.651101 — genomics — Posted on 2025-05-07

4932 A Dynamic Framework for Context Dependent Microbial Assembly: Validation of the Domain-Specific Stochastic Deterministic Integration Model (DSSDI)

WAN, M. T.; Liu, P.-J.

10.1101/2025.05.04.652157 — microbiology — Posted on 2025-05-07

4933 The dynamic transcriptome of Plasmodium malariae in the mosquito

Ruiz, J. L.; Diaz-Terenti, B.; Lefevre, T. D.; Yerbanga, S. R.; Otto, T. D.; Gomez-Diaz, E.

10.1101/2025.05.05.652270 — microbiology — Posted on 2025-05-07

4934 Molecular basis for the regulation of retroviral nucleosomal integration by chromatin compaction

Zgadzayy, Y.; Martins, F. G.; Bertinetti, C.; Autin, M.; Batisse, J.; Tumiotto, C.; Paul, L.; Ruff, M.; Sousa, S.; Parissi, V.

10.1101/2025.05.05.652197 — microbiology — Posted on 2025-05-07

4935 Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance to Streptococcus mutans phage ΦAPCM01

Wall, L. A.; Wall, D.

10.1101/2025.05.05.652303 — microbiology — Posted on 2025-05-07

4936 Grapevine phyllosphere pan-metagenomics reveals pan-microbiome structure, diversity, and functional roles in downy mildew resistance

Jin, J.; Wang, X.; Zhang, X.; Mei, J.; Zheng, W.; Guo, L.; Sun, H.; Zhang, L.; Liu, C.; Ye, W.; Guo, L.

10.1101/2025.05.04.652149 — microbiology — Posted on 2025-05-07

4937 Diverse and Flexible Strategies Enable Successful Cooperation in Marmoset Dyads

Meisner, O. C.; Shi, W.; Nair, A.; Nandy, G.; Jadi, M. P.; Nandy, A. S.; Chang, S. W. C.

10.1101/2025.05.06.652115 — neuroscience — Posted on 2025-05-07

4938 EGFR activation correlates with intracranial pressure and outcome in a mixed intracranial bleeding porcine model

Zhao, Z.; Hoffmann, A.; Groeger, M.; Kress, S.; Muenz, F.; Sun, F.; Merz, T.; Sheer, M.; Calzia, E.; Oezkan, B.; Radermacher, P.; Roselli, F.; Kapapa, T.; Pagliarini, M.

10.1101/2025.05.02.651431 — neuroscience — Posted on 2025-05-07

4939 Synaptic vesicles that store monoamines and glutamate differ in protein composition.

Asmerian, H.; Diaz, A. J.; Xu, H.; Oses-Prieto, J. A.; Alberts, J.; Sanetra, A. M.; Gnanabharathi, B.; Carr, N.; Burlingame, A. L.; Edwards, R. H.; Silm, K.

10.1101/2025.05.06.651945 — neuroscience — Posted on 2025-05-07

4940 The zoo of the gene networks capable of pattern formation by extracellular signaling

Anhon, K. M.; Ciudad, I. S.

10.1101/2025.05.06.652477 — systems biology — Posted on 2025-05-07

4941 HADDOCK3: A modular and versatile platform for integrative modelling of biomolecular complexes

Giulini, M.; Reys, V.; Teixeira, J. M. C.; Jimenez-Garcia, B.; Honorato, R. V.; Kravchenko, A.; Xu, X.; Versini, R.; Engel, A.; Verhoeven, S.; Bonvin, A. M. J. J.

10.1101/2025.04.30.651432 — bioinformatics — Posted on 2025-05-07

4942 Multi-parametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the Langendorff-perfused heart

Lee, I.-J. E.; Caldwell, J. L.; Mott, L. R.; Wang, L.; Ripplinger, C. M.

10.1101/2025.04.30.650917 — bioengineering — Posted on 2025-05-07

4943 NMNAT1 Binding at Promoters and Enhancers Couples NAD+ Synthesis to RNA Polymerase II Engagement

Cedeno-Cedeno, Y.; Taylor, S. J.; Gamble, M. J.; Steidl, U.; Coleman, R. A.

10.1101/2025.04.30.651499 — genomics — Posted on 2025-05-06

4944 Sample-specific CpG loci are important for accurate long-read methylation analysis

Hansen, S. B.; Hansen, K. D.; Limborg, M. T.

10.1101/2025.04.30.651558 — genomics — Posted on 2025-05-06

4945 Heterchronic shifts in a timing-keeping microRNA are associated with multiple instances of neoteny in plants

Leichty, A. R.; Poethig, R. S.

10.1101/2025.04.30.651569 — evolutionary biology — Posted on 2025-05-07

4946 Time-course Transcriptomics Reveals the Impact of Treponema pallidum on Microvascular Endothelial Cell Function and Phenotype

Waugh, S.; Goodyear, M. C.; Gomez, A.; Ranasinghe, A.; Lithgow, K. V.; Falsafi, R.; Hancock, R. E. W.; Lee, A. H.; Cameron, C. E.

10.1101/2025.05.04.651946 — molecular biology — Posted on 2025-05-06

4947 Alleviation of Drought Stress and Plant Growth Promotion in Mungbean through Rhizospheric Actinobacteria

Patel, M.; Singh, N. K.; Parmar, R. B.; Joshi, B. M.; Yadav, A.; Patel, Y.; Tapre, P. V.

10.1101/2025.05.05.652240 — microbiology — Posted on 2025-05-06

4948 Using a "one-strain-many-compounds" (OSMAC) approach to screen a collection of diverse fungi from Aotearoa New Zealand for antibacterial activity against Escherichia coli

van de Pas, S.; Cadelis, M. M.; Grey, A. B. J.; Flemming, J. M.; Park, D.; Lumley, T.; Weir, B. S.; Copp, B. R.; Wiles, S.

10.1101/2025.05.05.652310 — microbiology — Posted on 2025-05-06

4949 An Archaeal Transcription Factor Bridges Prokaryotic and Eukaryotic Regulatory Paradigms

Ferrer, F. M.; Nayak, D. D.

10.1101/2025.05.05.652248 — microbiology — Posted on 2025-05-06

4950 Genome Evolution of Acinetobacter baylyi ADP1 During Laboratory Domestication: Acquired Mutations Impact Competence and Metabolism

Gifford, I. S.; Vergis, M.; Barrick, J. E.

10.1101/2025.05.05.652239 — microbiology — Posted on 2025-05-06

4951 Evolved bacterial formate assimilation is likely potentiated by a rudimentary CO2 concentrating mechanism

Mazny, B. E.; LaSarre, B.; Govindaraju, A. M.; McKinlay, J. B.

10.1101/2025.05.05.652280 — microbiology — Posted on 2025-05-06

4952 Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead

Veeck, C.; Laube, L.; Werner, A. D.; Diederich, W.; Becker, S.

10.1101/2025.05.03.652023 — microbiology — Posted on 2025-05-07

4953 Drug screen reveals new potent host-targeted antivirals against Mpox virus

Arumugaswami, V.; Damoiseaux, R.; Kumar, A.; JEYACHANDRAN, A. V.; Zaiss, A. K.; Chakravarty, N.; Singh, S.; Delgado, Y.; Paravastu, R.; Satheeshkumar, N.; Gerald, E.; Jeysankar, A.; Thomas, J.; Fuller, L.; Lee, N.; Taylor, C.; Joshi, S.; Parcells, M. S.; French, S. W.; Date, A.; Bouhaddou, M.; Garcia, G.

10.1101/2025.05.02.651913 — microbiology — Posted on 2025-05-07

4954 Experimental evolution of promiscuous kin recognition from a homotypic specific cell surface receptor

Guo, T.; Wall, D.

10.1101/2025.05.04.652116 — microbiology — Posted on 2025-05-07

4955 Structural Interactions of Ankyrin B with NrCAM and β2 Spectrin

Chirasani, V. R.; Haberman, V. A.; Oldre, E. F.; Webb, B. D.; Pereira, E. B.; Yang, W.; Maness, P. F.

10.1101/2025.04.30.651523 — neuroscience — Posted on 2025-05-06

4956 Targeting the canonical ER stress IRE1α/XBP1 pathway counteracts pancreatic cancer-induced skeletal muscle wasting

Joshi, A. S.; Tomaz da Silva, M.; Vuong, A. T.; Xu, B.; Singh, R. K.; Kumar, A.

10.1101/2025.05.05.652304 — physiology — Posted on 2025-05-06

4957 Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

He, J.; Chen, B.; Wang, X.; Yang, R.; Deng, C.; Zhu, X.; Wang, K.; Wang, L.; Lu, X.; Peng, C.; Li, C.; Shan, Z.

10.1101/2025.05.06.652369 — molecular biology — Posted on 2025-05-06

4958 Swarm-seq Reveals Functional Divergence in CsrA Homologs Across Bacteria.

Winkelman, J. T.; Yarberry, E.; Winkelman, J. D.; Mukherjee, S.

10.1101/2025.05.05.652322 — microbiology — Posted on 2025-05-06

4959 Occurrence of Gray, 1838, (Chiroptera: Phyllostomidae) in Quaternary deposits of Lagoa Santa, Brazil

Chahud, A.

10.1101/2025.04.30.651513 — paleontology — Posted on 2025-05-06

4960 Computational modeling of necrosis in neural organoids

Pantula, A.; Zhou, B.; Morales Pantoja, I. E.; Fedotova, A.; George, D.; Alam El Din, D.-M.; Lysinger, A.; Smirnova, L.; Gracias, D. H.

10.1101/2025.04.30.651571 — bioengineering — Posted on 2025-05-06

4961 Structural insight into the transcription activation mechanism of the phage Mor/C family activators

Shi, J.; Ye, Z.; Huang, Y.; Xu, L.; Xu, S.; Xie, L.; Chen, W.; Wang, L.; Feng, Z.; Song, Q.; Wang, S.; Feng, Y.; Lin, W.

10.1101/2025.05.02.651988 — biochemistry — Posted on 2025-05-06

4962 Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus

Wee, D.; Pandey, M.; Chen, Y.; Lorenzini, P. A.; Chow, E. W.; Wang, Y.; Singhal, A.; Oehlers, S. H.

10.1101/2025.05.05.652332 — microbiology — Posted on 2025-05-06

4963 Phage growth rate is significantly affected by host-temperature and phage-temperature interactions

Garrison, P.; Padfield, D.; Martin, A.; Denby, J.; Mincey, C.; Knies, J. L.

10.1101/2025.05.06.651716 — microbiology — Posted on 2025-05-06

4964 The small membrane protein YohP induces membrane depolarization and ppGpp accumulation in Escherichia coli.

Natriashvili, A.; Mohammadsadeghi, N.; Milanov, M.; Smudde, E.; Prucker, I.; Jessen, H.; Carabadjac, I.; Heerklotz, H.; Franco, P. H. C.; Langer, J.; Koch, H.-G.

10.1101/2025.05.06.652344 — microbiology — Posted on 2025-05-06

4965 Simply cut out -Combining CRISPR/Cas9 RNPs and transiently selected telomere vectors for marker free-gene deletion in Trichoderma atroviride

Gruendlinger, M.; Ellensohn, C.; Drechsel, L.; Schreiner, U.; Pierson, S.; Baldin, C.; Zeilinger, S.

10.1101/2025.05.06.652419 — microbiology — Posted on 2025-05-06

4966 Tyrosine availability shapes Staphylococcus aureus nasal colonization and interactions with commensal communities

Camus, L.; Franz, J.; Gerlach, D.; Lange, A.; Power, J. J.; Navarro-Diaz, M.; Rapp, J.; Otto, M.; Klages, L. J.; Starostin, V.; Mössner, J.; Bilici, K.; Ham, S.; Kalinowski, J.; Angenent, L. T.; Link, H.; Heilbronner, S.

10.1101/2025.05.06.651429 — microbiology — Posted on 2025-05-06

4967 FliO is an evolutionarily conserved yet diversified core component of the bacterial flagellar type III secretion system

Andrianova, E. P.; Dobbins, A. L.; Erhardt, M.; Hendrixson, D. R.; Zhulin, I.

10.1101/2025.05.06.652439 — microbiology — Posted on 2025-05-06

4968 Development, validation, and evidence of frequent exchange of mating type HD alleles of Puccinia striiformis f. sp. tritici provide an insight into highly genetic diversity

Li, S.; Sun, M.; Du, Z.; Cheng, X.; Yang, L.; Ju, M.; Kang, Z.; Zhao, J.

10.1101/2025.05.06.652357 — microbiology — Posted on 2025-05-06

4969 Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

Wobma, H.; Alvarez Calderon, F.; Dong, J.; Omdahl, K.; Rui, X.; Rojas Palato, E. J.; Bermea, R. S.; Albanese, A.; Wachter, F.; Winschel, M.; Michaelis, K. A.; Cagnin, L.; Tkachev, V.; Prockop, S. E.; Nigrovic, P. A.; Blazar, B. R.; Gerdemann, U.; Kean, L. S.

10.1101/2025.04.30.651441 — immunology — Posted on 2025-05-06

4970 A Highly Protective Clade 1 and 2 Cross-Reactive Pandemic Influenza Virus Vaccine Based on a 4th Generation Fully Deleted Adenoviral Vector of a Rare Serotype

Staerz, U. D.; Qi, Y.; Bowen, R. A. D.; Cull, J. W.; Kelly, J.; Klimenova, X.; Hartwig, A. T.

10.1101/2025.04.30.651579 — immunology — Posted on 2025-05-06

4971 The tail of myliobatid rays controls body stability

Chaumel, J.; White, C. F.; Lauder, G. V.

10.1101/2025.04.30.651532 — zoology — Posted on 2025-05-06

4972 Engineering Artificial 5' Regulatory Sequences for Thermostable Protein Expression in the Extremophile Thermus thermophilus

Wong, C. F. A.; Zhang, S.; Tietze, L.; Dahiya, G. S.; Lale, R.

10.1101/2025.05.06.652417 — synthetic biology — Posted on 2025-05-06

4973 Parental age selection in C. elegans influences progeny stress resistance capacity

Van Camp, B. T.; Curran, S. P.

10.1101/2025.04.30.651556 — physiology — Posted on 2025-05-06

4974 Modeling and Prediction of Body Segment Inertial Properties of Sheep from Tomographic Imaging

Henry, A.; Benner, C. M.; Covan, B.; Helin, A.; Gaddy, D.; Suva, L.; Robbins, A. B.

10.1101/2025.04.30.651518 — bioengineering — Posted on 2025-05-06

4975 3D osteocyte networks under Pulsatile Unidirectional Fluid Flow Stimuli (PUFFS)

Merife, A.-B.; Poudel, A.; Polshchikova, A.; Geffert, Z. J.; Horton, J.; Akash, M. M. H.; Pandey, A.; Basu, S.; Fougnier, D.; Soman, P.

10.1101/2025.04.30.651549 — bioengineering — Posted on 2025-05-06

4976 ArchLips: A comprehensive in silico database for high-throughput identification of archaeal lipids

Zheng, F.; Yao, W.; He, W.; Zhang, W.; Chen, Y.; Chen, H.; Zeng, Z.; Liu, X.-L.; Ding, S.; Zheng, Y.; Huang, L.; Zhu, Y.; Zhang, C.

10.1101/2025.05.05.652033 — biochemistry — Posted on 2025-05-06

4977 Development of a Two-Stage Life Cycle Model to Inform the Trap and Haul Program for Coho Salmon in the Lewis River, Washington

Perry, R. W.; Plumb, J. M.

10.1101/2025.04.30.651546 — ecology — Posted on 2025-05-06

4978 Failure to meet the exchangeability assumption in Bayesian multispecies occupancy models: Implications for study design

Cotterill, G.; Keinath, D.; Graves, T.

10.1101/2025.04.30.651473 — ecology — Posted on 2025-05-06

4979 Thermal Dynamics of Ectotherm Behavioral Strategies: Insights from Agent-Based Simulations

Remington, M.; Clark, R. W.; Hanscom, R. J.; Higham, T. E.; Sukumaran, J.

10.1101/2025.04.30.651512 — ecology — Posted on 2025-05-06

4980 A Cluster of Acidic Residues in the Cytoplasmic Domain of SARS-CoV-2 Spike is Required for Virion-Incorporation and Infectivity

Stoneham, C. A.; Singh, R.; De Leon, A.; Tafelmeyer, P.; Acosta, F.; Fuori, A.; Anderson, M.; Ramirez, P. W.; Schwartzer-Sperber, H. S.; Pillai, S. K.; Lewinski, M. K.; Guatelli, J.

10.1101/2025.05.04.652125 — molecular biology — Posted on 2025-05-06

4981 Induction of hypoxic response despite normoxic conditions associated with vascular mitochondrial dysfunction in diet induced metabolic syndrome

MADAN, D. E.; Jain, V.; Singh, V. P.

10.1101/2025.05.05.652328 — molecular biology — Posted on 2025-05-06

4982 Programmed DNA breaks drive chromatin reconfiguration and facilitate transcriptional potentiation at neuronal early response genes

Heady, L.; Rueda, R.; Segev, A.; Morton, K. G.; Madabhushi, R.

10.1101/2025.05.06.652469 — molecular biology — Posted on 2025-05-06

4983 Defence systems drive accessory genome interactions in Pseudomonas aeruginosa.

Chong, C. E.; Weimann, A.; Agapov, A.; Fothergill, J. L.; Brockhurst, M. A.; Parkhill, J.; Floto, R. A.; Szczelkun, M.; Westra, E. R.; Consortium, M.-D.; Baker, K. S.

10.1101/2025.05.06.652404 — microbiology — Posted on 2025-05-06

4984 Maltose facilitates Salmonella growth under nitrogen stress while impairing adhesion to epithelial cells

Parmar, K.; Selvaraj, J.; Nayak M, M.; Karmakar, K.; Bagchi, S.; Chakravortty, D.

10.1101/2025.05.06.652415 — microbiology — Posted on 2025-05-06

4985 Tracking polyhydroxyalkanoate biosynthesis in thermophilic microorganisms

Schroyen, B.; Moanis, R.; Geeraert, H.; Van den Brande, N.; Hennecke, U.; Obruca, S.; Buchtikova, I.; Sedlar, K.; Sedlacek, P.; Peeters, E.

10.1101/2025.05.06.652502 — microbiology — Posted on 2025-05-06

4986 A cell-free bacterial signal orchestrates trans-kingdom fitness tradeoff to enhance sulfur deficiency tolerance in plants

Mukherjee, A.; Mazumder, M.; Verma, A.; Tikariha, H.; Bhattacharya, R.; En, O. Q.; Swarup, S.

10.1101/2025.05.06.652065 — microbiology — Posted on 2025-05-06

4987 A prophage-encoded sRNA limits lytic phage infection of adherent-invasive E. coli

Brzozowski, R. S.; Schmidt, A. K.; Pershing, N. L.; Dankwardt, A.; Faith, D. R.; Joyce, A. C.; Maciver, A.; Henriques, W. S.; Andersen, S. E.; Wiedenheft, B.; Casjens, S.; Duerkop, B. A.; Round, J. L.; Secor, P. R.

10.1101/2025.05.06.652453 — microbiology — Posted on 2025-05-06

4988 Oligomerization of the Clostridioides difficile Transferase B Component Proceeds through a Stepwise Mechanism

Mullard, R. M.; Sheedlo, M. J.

10.1101/2025.05.06.652354 — microbiology — Posted on 2025-05-06

4989 Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector

Pennance, T.; Spaan, J.; Xiong, Y.; Churan, A.; Loczi-Storm, A.; Ward, D.; Islam, T.; Calcote, A.; Fuller, E.; Marsonette, B.; Odiere, M.; Steinauer, M.

10.1101/2025.05.06.651976 — microbiology — Posted on 2025-05-06

4990 The Gfr uptake system provides a context-dependent fitness advantage to Salmonella Typhimurium SL1344 during the initial gut colonization phase

Fuchs, L.; Dieterich, C. L.; Ros, E. M.; Keller, P.; Laganenka, L.; Schubert, C.; Vorholt, J. A.; Piel, J.; Hardt, W.-D.; Nguyen, B. D.

10.1101/2025.05.06.652348 — microbiology — Posted on 2025-05-06

4991 Associations between infant gut microbiota and the living environment

Hickman, B.; Salonen, A.; Kolho, K.-L.; de Vos, W.; Korpela, K.

10.1101/2025.05.06.651416 — microbiology — Posted on 2025-05-06

4992 High-throughput cultivation and isolation of environmental anaerobes using selectively permeable hydrogel capsules

Sallet, H.; Calvo, M.; Titus, M.; Jacquemin, N.; Meibom, K. L.; Bernier-Latmani, R.

10.1101/2025.05.06.652511 — microbiology — Posted on 2025-05-06

4993 Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential

Perfilyev, A.; Shen, A.; Hooton, S.; Zahran, S. A.; Winther-Have, C. S.; Kalatzis, P.; Wilkinson, R. C.; Thanki, A. M.; Petersen, B.; Liu, Z.; Zhang, Q.; Liu, Y.; Ibarra-Chavez, R.; Gigante, A.; Lv, Q.; Atterbury, R.; Millard, A. D.; Clokie, M. R. J.; Sicheritz-Ponten, T.

10.1101/2025.05.06.652010 — microbiology — Posted on 2025-05-06

4994 Salmonella relies on siderophore exploitation at low pH

Ferry, M.; Schalk, I. J.; Cunrath, O.

10.1101/2025.05.06.652355 — microbiology — Posted on 2025-05-06

4995 Single-cell transcriptomic profiling reveals a novel signature of necrotizing granulomatous lesions in the lungs of Mycobacterium tuberculosis-infected C3HeB/FeJ mice

Seto, S.; Ohmori, S.; Nakamura, H.; Hijikata, M.; Keicho, N.

10.1101/2025.05.06.652098 — microbiology — Posted on 2025-05-06

4996 Mechanistic Insights into Human Antimicrobial Peptide-Induced Activation of a Broadly Conserved Bacterial Signaling System

Adeleye, S. A.; Mechesso, A. F.; Mukherjee, A.; Wang, G.; Yadavalli, S. S.

10.1101/2025.05.06.652532 — microbiology — Posted on 2025-05-06

4997 Baseline State for Pulmonary Vasculature with Pulmonary Arterial Hypertension: Effect of Geometric Remodeling and Metabolic Shift

Mullagura, H. N.; Gharahi, H.; Figueroa, C. A.; Baek, S.

10.1101/2025.04.30.651520 — systems biology — Posted on 2025-05-06

4998 Boltz-1: Democratizing Biomolecular Interaction Modeling

Wohlwend, J.; Corso, G.; Passaro, S.; Getz, N.; Reveiz, M.; Leidal, K.; Swiderski, W.; Atkinson, L.; Portnoi, T.; Chinn, I.; Silterra, J.; Jaakkola, T.; Barzilay, R.

10.1101/2024.11.19.624167 — biophysics — Posted on 2025-05-06

4999 The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci

Weldy, C. S.; Kundu, S.; Monteiro, J. P.; Gu, W.; Pedroza, A. J.; Dalal, A. R.; Worssam, M. D.; Li, D. Y.; Palmisano, B. T.; Zhao, Q.; Sharma, D.; Nguyen, T.; Kundu, R. K.; Fischbein, M. P.; Engreitz, J.; Kundaje, A. B.; Cheng, P. P.; Quertermous, T.

10.1101/2022.05.18.492517 — genomics — Posted on 2025-05-06

5000 Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex

Shin, J.; Lee, S. Y.; Kim, Y.; Lee, S.-H.

10.1101/2024.09.10.612266 — neuroscience — Posted on 2025-05-06

5001 Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

10.1101/2025.05.02.651974 — neuroscience — Posted on 2025-05-06

5002 A pair of dopaminergic neurons DAN-c1 mediate Drosophila larval aversive olfactory learning through D2-like receptors

Qi, C.; Qian, C.; Steijvers, E.; Colvin, R. A.; Lee, D.

10.1101/2024.01.15.575767 — neuroscience — Posted on 2025-05-06

5003 Activating the CXCR3/CXCL10 pathway overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in head and neck squamous cell carcinoma

Shinn, C. K.; Saddawi-Konefka, R.; Salanga, C.; Schokrpur, S.; Gutkind, J. S. K.; Handel, T. M.

10.1101/2025.04.24.650529 — cancer biology — Posted on 2025-05-06

5004 Molecular and Mechanical Signatures Contributing to Epidermal Differentiation and Barrier Formation

Prado-Mantilla, A.; Ning, W.; Lechler, T.

10.1101/2024.07.23.604736 — developmental biology — Posted on 2025-05-06

5005 Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity

Golf, S. R.; Trotter, J.; Wang, J.; Nakahara, G.; Han, X.; Wernig, M.; Südhof, T.

10.1101/2023.04.10.536254 — neuroscience — Posted on 2025-05-06

5006 Decoding mesolimbic dopamine transmission in the olfactory tubercle and its contribution to methamphetamine responses through neurochemical sensing and chemogenetics

Bhimani, R. V.; Pauly, R. C.; Bass, C. E.; Park, J.

10.1101/2024.11.12.622180 — neuroscience — Posted on 2025-05-06

5007 Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles

Busch, G. T.; Boe, R. H.; Li, J.; Gruener, R. F.; Arnett, M. J.; Ravindran, P. T.; Herlyn, M.; Huang, R. S.; Raj, A.

10.1101/2025.04.25.650475 — systems biology — Posted on 2025-05-06

5008 Atomistic Simulation of Voltage Activation of a Truncated BK Channel

Jia, Z.; Chen, J.

10.1101/2025.01.08.631907 — biophysics — Posted on 2025-05-06

5009 scBaseCount: An AI agent-curated, uniformly processed, and continually expanding single cell data repository

Youngblut, N. D.; Carpenter, C.; Prashar, J.; Ricci-Tam, C.; Ilango, R.; Teyssier, N.; Konermann, S.; Hsu, P.; Dobin, A.; Burke, D. P.; Goodarzi, H.; Roohani, Y. H.

10.1101/2025.02.27.640494 — bioinformatics — Posted on 2025-05-06

5010 FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research

Al Manir, S.; Levinson, M. A.; Niestroy, J.; Churas, C.; Parker, J. A.; Clark, T.

10.1101/2024.12.23.629818 — bioinformatics — Posted on 2025-05-06

5011 Small form factor implantable neural probe with efficient flip chip micro LED for in vivo optogenetics

Abrantes, M.; Pereira, T.; Silva, P.; Falcao, M.; Borme, J.; Alpuim, P.; Jacinto, L.

10.1101/2024.11.17.624006 — bioengineering — Posted on 2025-05-06

5012 Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

Hochmair, J.; van den Oetelaar, M. C. M.; Ravatt, L.; Diez, L.; Lemmens, L. J. M.; Ponce Lina, R.; Sankar, R.; Franck, M. W.; Nolte, G.; Semenova, E.; Mohapatra, S.; Ottmann, C. O.; Brunsveld, L.; Wegmann, S.

10.1101/2024.03.15.585148 — biochemistry — Posted on 2025-05-06

5013 Identifying in vivo genetic dependencies of melanocyte and melanoma development

Perlee, S.; Ma, Y.; Hunter, M. V.; Swanson, J. B.; Cruz, N. M.; Ming, Z.; Xia, J.; Lionnet, T.; McGrail, M.; White, R.

10.1101/2024.03.22.586101 — genetics — Posted on 2025-05-06

5014 Sexual tail dimorphism explains speciation rate in swallows and martins

Hasegawa, M.

10.1101/2024.12.11.627946 — evolutionary biology — Posted on 2025-05-06

5015 Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

Peshkin, L.; Daldello, E. M.; Van Itallie, E. S.; Sonnett, M.; Kreuzer, J.; Haas, W.; Kirschner, M. W.; Jessus, C.

10.1101/2024.07.26.605364 — developmental biology — Posted on 2025-05-06

5016 The neural basis of cost-benefit trade-offs in effort investment: a quantitative activation likelihood estimation meta-analysis

Edgar, N.; da Silva Castanheira, K.; Turner, G. R.; Spreng, N.; Vassena, E.; Otto, A. R.

10.1101/2022.10.28.513278 — neuroscience — Posted on 2025-05-06

5017 Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety

Mourra, D.; Murphy, C. E.; Hourany, E.; Centeno, K.; Gnazzo, F.; Beeler, J. A.

10.1101/2025.04.29.651295 — neuroscience — Posted on 2025-05-06

5018 Regional deficits in endogenous regeneration of mouse olfactory sensory neuron axons

Kunkhyen, T.; Curtis, K. A.; Deakin, T. P.; Huang, J. S.; Gregory, J. D.; Cheetham, C. E. J.

10.1101/2024.10.06.616907 — neuroscience — Posted on 2025-05-06

5019 Cross-order detection of bacteriophage transduction in communities using ribosomal RNA barcoding

LaTurner, Z. W.; Dysart, M. J.; Schwartz, S. K.; Zeng, E.; Chappell, J.; Silberg, J. J.; Stadler, L. B.

10.1101/2025.05.03.652062 — synthetic biology — Posted on 2025-05-06

5020 Residue-level structural information from isotope-edited FTIR spectroscopy reveals distinct molecular structures of different amyloid-β42 oligomers

Vosough, F.; Carstensen, S. M.; Baronio, C. M.; Barth, A.

10.1101/2025.03.31.646305 — biophysics — Posted on 2025-05-06

5021 Ionizable networks mediate pH-dependent allostery in SH2 signaling proteins

Van Dyck, P. K.; Piszkin, L.; Gorski, E. A.; Tartarella Nascimento, E.; Abebe, J. A.; Hoffmann, L. M.; Peng, J. W.; White, K. A.

10.1101/2024.08.21.608875 — biochemistry — Posted on 2025-05-06

5022 Coordinated regulation of Mdr1- and Cdr1-mediated protection from antifungals by the Mrr1 transcription factor in emerging Candida spp.

Rajesh-Khanna, D.-S.; Pina Paez, C. G.; Dolan, E. G.; Mirpuri, K. S.; Stajich, J. E.; Hogan, D. A.

10.1101/2025.05.04.652153 — microbiology — Posted on 2025-05-06

5023 Simultaneous Sensing and Stimulation in Neuromodulation Systems: Quantifying and Mitigating Charge Accumulation Effects

Orser, H.; Doan, P.

10.1101/2025.04.30.651467 — bioengineering — Posted on 2025-05-06

5024 Analysis of the economic viability and environmental impacts of a conceptual process for the recovery of lactic acid from spent media in cultivated meat production

Wimble, J.; Ashizawa, R.; Swartz, E. W.

10.1101/2025.04.30.651479 — bioengineering — Posted on 2025-05-06

5025 P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Zaatra, W.; Philippos, G.; Smirnov, P.; Cochavi, S. M.; Otonicar, J.; Chan, M.; Harel, M.; Devens, F.; Goldberg, T.; Eliassaf, A.; Grimes, K.; Irony-Tur Sinai, M.; Sigismondo, G.; Geiger, T.; Korbel, J.; Krijgsveld, J.; Shalev, O.; Kerem, B.; Ernst, A.

10.1101/2025.04.17.649416 — cancer biology — Posted on 2025-05-06

5026 Single-cell alternative polyadenylation analysis reveals mechanistic insights of COVID-19-associated neurological and psychiatric effects

Ning, W.; Chen, Q.; Gu, Y.; Liu, S.; Li, X.; Xu, R.; Ye, R.; Yang, J.

10.1101/2025.05.02.651855 — bioinformatics — Posted on 2025-05-06

5027 Quantifying uncertainty in Protein Representations Across Models and Task

Prabakaran, R.; Bromberg, Y.

10.1101/2025.04.30.651545 — bioinformatics — Posted on 2025-05-06

5028 Density-dependent network structuring within and across wild animal systems

Albery, G. F.; Becker, D. J.; Firth, J. A.; De Moor, D.; Ravindran, S.; Silk, M.; Sweeny, A. R.; Wal, E. V.; Webber, Q.; Allen, B.; Babayan, S. A.; Barve, S.; Begon, M.; Birtles, R. J.; Block, T. A.; Block, B. A.; Bradley, J. E.; Budischak, S.; Buesching, C.; Burthe, S. J.; Carlisle, A. B.; Caselle, J. E.; Cattuto, C.; Chaine, A. S.; Chapple, T.; Cheney, B. J.; Clutton-Brock, T.; Collier, M.; Curnick, D. J.; Delahay, R. J.; Farine, D. R.; Fenton, A.; Ferretti, F.; Fielding, H.; Foroughirad, V.; Frere, C.; Gardner, M. G.; Geffen, E.; Godfrey, S. S.; Graham, A. L.; Hammond, P. S.; Henrich, M.; H

10.1101/2024.06.28.601262 — ecology — Posted on 2025-05-06

5029 Stealth replication of SARS-CoV-2 Omicron in the nasal epithelium at physiological temperature

Fonseca, B. F.; Robinot, R.; Michel, V.; Mendez, A.; Lebourgeois, S.; Chive, C.; Jeger-Madiot, R.; Vaid, R.; Bondet, V.; Maloney, E.; Guivel-Benhassine, F.; Schwartz, O.; Duffy, D.; Mondal, T.; Gobaa, S.; Chakrabarti, L. A.

10.1101/2025.05.03.652024 — microbiology — Posted on 2025-05-05

5030 Do Existing COVID-19 Vaccines Need to Be Updated in 2025?

Mellis, I. A.; Wu, M.; Wang, Q.; Bowen, A.; Gherasim, C.; Pierce, V. M.; Shah, J. G.; Purpura, L. J.; Yin, M. T.; Gordon, A.; Guo, Y.; Ho, D. D.

10.1101/2025.05.02.651777 — microbiology — Posted on 2025-05-05

5031 Staphylococcus aureus COL: An Atypical Model Strain of MRSA that Exhibits Slow Growth and Antibiotic Tolerance Due to a Mutation in PRPP Synthetase

Stevens, C. E.; Deventer, A. T.; Johnston, P. R.; Lowe, P. T.; Boraston, A. B.; Hobbs, J. K.

10.1101/2024.12.12.627954 — microbiology — Posted on 2025-05-06

5032 H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves

Souza, C. K.; Santos, J. J. S.; Boggiatto, P.; Sterle, H.; Arruda, B.; Palmer, M. V.; Campos, A.; Liu, J.; Ye, N.; Weissman, D.; Hensley, S. E.; Baker, A. L.

10.1101/2025.05.01.651548 — microbiology — Posted on 2025-05-06

5033 Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

Chung, J.; Vallurupalli, M.; Noel, S.; Schor, G.; Liu, Y.; Nobrega, C.; Perera, J.; Wrona, E.; Hu, M.; Lin, Y.; Wu, D. w.; Saberi, M.; Scapozza, I.; Cruickshank, A.; Woods, E. C.; Chuong, C. L.; Birocchi, F.; Kammula, A.; Avila, O. I.; Kocak, M.; Doench, J. G.; Procter, D.; Thornton, L.; Brunner, A. M.; Winer, E.; DeAngelo, D. J.; Garcia, J. S.; Stone, R. M.; Jenkins, R. W.; Maus, M. V.; Graubert, T. A.; Yates, K. B.; Golub, T. R.; Manguso, R. T.

10.1101/2025.05.05.652090 — cancer biology — Posted on 2025-05-06

5034 Conduction pathway for potassium through the E. coli pump KdpFABC

Hussein, A.; Zhang, X.; P. Pedersen, B.; Stokes, D. L.

10.1101/2025.05.05.652293 — biophysics — Posted on 2025-05-06

5035 Quantifying Intracellular Mechanosensitive Response upon Spatially Defined Mechano-Chemical Triggering

Zare-Eelanjegh, E.; Lewis, R. T.; Lüchtefeld, I.; Kutay, U.; Zambelli, T.

10.1101/2025.05.04.652118 — biophysics — Posted on 2025-05-06

5036 Disentangling the impacts of abiotic and biotic environmental factors anddispersal dynamics on the pangenome fluidity of bacterial pathogens

Goh, Y.-X.; Hardeep, F.; Zhang, H.; Liao, J.

10.1101/2025.03.27.645760 — genomics — Posted on 2025-05-06

5037 Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis

Azlan, A.; Zhu, L.; Fukunaga, R.

10.1101/2024.10.04.616675 — genetics — Posted on 2025-05-06

5038 Desmodium Volatiles in "Push-Pull" Cropping Systems and Protection Against the Fall Armyworm, Spodoptera frugiperda

Odermatt, D. M.; Chidawanyika, F.; Mutyambai, D. M.; Schmid, B.; Domeignoz Horta, L. A.; Onjura, C. O.; Tamiru, A.; Schuman, M. C.

10.1101/2024.07.24.604900 — ecology — Posted on 2025-05-06

5039 Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

Kaper, D.; Radovic, U.; Bergh, P.-O.; Qvist, A.; Henricsson, M.; Boren, J.; Pilon, M.

10.1101/2024.11.08.622646 — cell biology — Posted on 2025-05-06

5040 Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancer

10.1101/2025.05.05.651897 — immunology — Posted on 2025-05-06

5041 Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough

Naqvi, K. F.; Warden, L. L.; van Dijk, J. H. M.; Naik, D. K.; Espinosa-Becarra, F. d. J.; Okolie, I. M.; Verhoeks, V. F. H.; Rahlwes, K. C.; Xavier, C. P.; Codee, J. D. C.; Price, T. J.; Shiloh, M. U.

10.1101/2025.05.01.651726 — neuroscience — Posted on 2025-05-06

5042 FKSFold: Improving AlphaFold3-Type Predictions of Molecular Glue-Induced Ternary Complexes with Feynman-Kac-Steered Diffusion

Shen, J.; Zhou, S.; Che, X.

10.1101/2025.05.03.651455 — biophysics — Posted on 2025-05-06

5043 Deep Learning-Based Classification of Peptide Analytes from Single-Channel Nanopore Translocation Events

Krantz, B.

10.1101/2025.05.04.652126 — biophysics — Posted on 2025-05-06

5044 Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909

Laughlin, Z. T.; Arifova, L.; Munoz-Tello, P.; Yu, X.; Dong, J.; Harp, J. M.; Zu, D.; Kamenecka, T. M.; Kojetin, D. J.

10.1101/2025.05.04.651770 — biophysics — Posted on 2025-05-06

5045 Pathogenic Missense Mutations in Intrinsically Disordered Regions Reveal Functional and Clinical Signals

Deutsch, N.; Erdos, G.; Dosztanyi, Z.

10.1101/2025.05.01.651640 — bioinformatics — Posted on 2025-05-06

5046 All-Atom Modeling and Simulation of Biopolymer Interface: Dual Role of Antifouling Polymer Brushes

Kim, S.; Yang, Z.; Jakowski, J.; Ganesh, P.; Retterer, S.; Carrillo, J.-M.

10.1101/2025.05.02.651893 — bioengineering — Posted on 2025-05-06

5047 Interplay Between Intrinsically Disordered Proteins and Atomically Precise Gold Nanoclusters Modulates their Optical Properties

Rodriguez, S.; Kumanski, S.; Ayed, Z.; Fournet, A.; Bouanchaud, C.; Sagar, A.; Allemand, F.; Resch-Genger, U.; Cortes, J.; Sibille, N.; Chirot, F.; Wegner, K. D.; Antoine, R.; Le Guevel, X.; Bernado, P.

10.1101/2025.05.06.652423 — biochemistry — Posted on 2025-05-06

5048 Antibody response to Aedes aegypti D7L1+2 salivary proteins as marker of aggregate vector exposure and correlate of dengue virus susceptibility

Bahr, L.; Hamins-Puertolas, M.; Buddhari, D.; Petzlova, I.; Oliveira, F.; Thomas, S. J.; Thangamani, S.; Waickman, A.; Anderson, K.

10.1101/2025.05.01.651659 — immunology — Posted on 2025-05-06

5049 H2O2-induced astrocytic collagen triggers neuronal death via fucosylation-dependent glial barrier formation upon ischemic stroke

Lee, J.-H.; Hwang, I.-Y.; Jang, H. J.; Lim, J.; Jung, J.; Kim, M.; Lee, E.; Won, W.; Lee, E. H.; Kim, K. J.; Park, K. D.; Jung, W.; Lee, B.; Ryu, S.; Lee, C. J.

10.1101/2025.05.01.651594 — neuroscience — Posted on 2025-05-06

5050 Temperature-Resolved Crystallography Reveals Rigid-Body Dominance Over Local Flexibility in B-Factors

Ribeiro, F. S.; Lima, L. M. T.

10.1101/2025.05.05.652037 — biophysics — Posted on 2025-05-06

5051 NMR Spectral Alignment Utilizing a CryoEM Motion Correction Algorithm

Hemme, C.; Warmuth, O.; Wang, S.; Williams, C.; Thome, A.; Mueller, L. J.; Rienstra, C. M.; Grant, T.

10.1101/2025.05.05.652277 — biophysics — Posted on 2025-05-06

5052 Ultra-High Resolution Solid-State NMR for High Molecular Weight Proteins on GHz-Class Spectrometers

Wang, S.; Ravula, T.; Stringer, J. A.; Gor'kov, P.; Warmuth, O.; Williams, C.; Thome, A.; Mueller, L. J.; Rienstra, C. M.

10.1101/2025.05.05.652283 — biophysics — Posted on 2025-05-06

5053 Inferring diffusion, reaction, and exchange parameters from imperfect FRAP

Lorenzetti, E.; Municio-Diaz, C.; MINC, N.; Boudaoud, A.; Fruleux, A.

10.1101/2025.05.06.652329 — biophysics — Posted on 2025-05-06

5054 Top-Down Scoring of Spectral Fitness by Image Analysis for Protein Structure Validation

Harding, B. D.; DeZonia, B.; Garg, R.; Hu, Z.; Delaglio, F.; Grant, T.; Rienstra, C. M.

10.1101/2025.05.05.652267 — biophysics — Posted on 2025-05-06

5055 Simultaneous particle tracking, phase retrieval and point spread function reconstruction

Fazel, M.; Hoseini, R.; Mahmoodi, M.; Xu, L. W. Q.; Saurabh, A.; Kilic, Z.; Antolin, J.; Scrudders, K. L.; Shepherd, D. P.; Low-Nam, S. T.; Huang, F.; Presse, S.

10.1101/2025.05.02.651986 — biophysics — Posted on 2025-05-06

5056 Design and Characterisation of Photoactivatable and Lysine Reactive o-Nitrobenzyl Alcohol-Based Crosslinkers

Cahill, A.; Walko, M.; Fenton, B.; Ganji, S. R.; Herbert, A.; Radford, S.; Kapur, N.; Livingstone, K.; Wright, M.; Calabrese, A. N.

10.1101/2025.05.06.652371 — biophysics — Posted on 2025-05-06

5057 Environment dependent benefits of sociality in Soay sheep

Siracusa, E. R.; Bal, X.; De Moor, D. R.; Albery, G. F.; Beattie, R.; Ravindran, S.; Wiersma, E.; Renwick Wilson, A.; Pemberton, J. M.; Nussey, D.; Silk, M. J.

10.1101/2025.05.04.652099 — animal behavior and cognition — Posted on 2025-05-06

5058 Cellular integration of beneficial de novo emerging proteins via ancient pathways

Houghton, C. J.; Castilho Coelho, N.; Chiang, A.; Hedayati, S.; Parikh, S. B.; Ozbaki-Yagan, N.; Wacholder, A.; Iannotta, J.; Berger, A.; Wohlever, M. L.; Carvunis, A.-R.; O'Donnell, A. F.

10.1101/2024.08.28.610198 — evolutionary biology — Posted on 2025-05-06

5059 Leishmania tarentolae and Leishmania infantum in geckos from Mallorca Island, Spain

Marti-Carreras, J.; Espunyes, J.; Carrera-Faja, L.; Pasetto, C.; Alcover Amengual, M. M.; Chavez-Fisa, S.; Carrasco, M.; Roura, X.; Francino, O.; Ferrer, L.

10.1101/2025.02.06.636881 — microbiology — Posted on 2025-05-06

5060 Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Habib, R.; Roark, R. S.; Li, H.; Connell, A. J.; Hogarty, M. P.; Wagh, K.; Wang, S.; Marchitto, L.; Skelly, A. N.; Carey, J. W.; Sowers, K. J.; Ayyanathan, K.; Plante, S. J.; Bibollet-Ruche, F.; Park, Y.; Agostino, C. J.; Singh, A.; Martella, C. L.; Lewis, E.; Lora, J.; Ding, W.; Campion, M. S.; Zhao, C.; Liu, W.; Li, Y.; Li, X.; Liang, B.; Chowdhury, R. R.; Amereh, K.; Van Itallie, E.; Sheng, Z.; Ghosh, A. R.; Bar, K. J.; Williams, W. B.; Wiehe, K.; Saunders, K. O.; Edwards, R. J.; Cain, D. W.; Lewis, M.; Batista, F. D.; Burton, D. R.; Andrabi, R.; Kulp, D. W.; Haynes, B. F.; Korber, B.; Shap

10.1101/2025.05.03.652068 — immunology — Posted on 2025-05-06

5061 Methionine oxidation of TRPV2 regulates thermogenesis in brown adipocytes

Iwase, M.; Kawarasaki, S.; Goto, T.; Uchida, K.

10.1101/2025.05.02.651863 — physiology — Posted on 2025-05-06

5062 An in vivo model for transcranial direct current stimulation of the motor cortex in awake mice.

Sanchez-Leon, C. A.; Reyes-Velasquez, P. A.; van Thriel, C.; Nitsche, M. A.

10.1101/2025.04.30.651337 — neuroscience — Posted on 2025-05-06

5063 When do peripherally encoded memories generalize in visual working memory?

Kandemir, G.; Olivers, C. N. L.

10.1101/2025.04.30.651449 — neuroscience — Posted on 2025-05-06

5064 The Optimal Retinal Locus for High-Resolution Vision in Space and Time

Gautier, J.; Bowers, N. R.; Banks, M. S.; Roorda, A.

10.1101/2025.04.30.650879 — neuroscience — Posted on 2025-05-06

5065 CRISPRi perturbation screens and eQTLs provide complementary and distinct insights into GWAS target genes

Ghatan, S.; Panten, J.; Oliveros, W.; Sanjana, N. E.; Morris, J. A.; Lappalainen, T.

10.1101/2025.05.05.651929 — genomics — Posted on 2025-05-06

5066 Comparative functional and evolutionary analysis of essential germline stem cell genes across the genus Drosophila and two outgroup species

Arnce, L.; Bubnell, J. E.; Aquadro, C. F.

10.1101/2025.04.30.651540 — genetics — Posted on 2025-05-06

5067 Exploring the double-stranded DNA viral landscape in eukaryotic genomes

Zhao, H.; Meng, L.; Zhang, R.; Gaia, M.; Ogata, H.

10.1101/2025.04.19.649669 — microbiology — Posted on 2025-05-06

5068 Chikungunya virus non-structural protein 2 (nsP2) inhibits RIG-I and TLR-mediated immune response

Raj, S.; Ranjith-Kumar, C. T.; Irfan, M.

10.1101/2025.04.30.651505 — immunology — Posted on 2025-05-06

5069 Group identification drives brain integration for collective performance

Enhui, X.; Zha, S.; Xu, Y.; Li, X.

10.1101/2024.06.03.597223 — neuroscience — Posted on 2025-05-06

5070 MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities

Zhang, W.; Good, Z.; Baertsch, M. A.; Lu, G.; Hickey, J. W.; Hildebrand, R.; Chang, S.; Gentles, A. J.; Sunwoo, J. B.; Le, Q.-T.; Kong, C.; Nolan, G. P.; Plevritis, S. K.

10.1101/2025.04.30.651486 — systems biology — Posted on 2025-05-06

5071 Multiomic clocks to predict phenotypic age in mice

Vera, D.; Griffin, P. T.; Leigh, D.; Kras, J.; Ramos, E.; Bishof, I.; Butler, A.; Chwalek, K.; Vogel, D.; Kane, A. E.; Sinclair, D. A.

10.1101/2025.04.30.651114 — systems biology — Posted on 2025-05-06

5072 The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae

Yen, P.-S.; Verkuijl, S. A.; Capriotti, P.; Del Corsano, G.; Hoermann, A.; Inghilterra, M. G.; Aramburu-Gonzalez, I.; Khan, M. A.; Christophides, G. K.; Vlachou, D.; Windbichler, N.

10.1101/2025.05.02.651860 — synthetic biology — Posted on 2025-05-06

5073 Mechanisms and Plasticity in Leaves and Leaflets in a Creeping Legume, Mimosa pudica

Kellogg, M. T.

10.1101/2025.05.03.652067 — plant biology — Posted on 2025-05-06

5074 Liquid-phase determination of Arabidopsis respiration and photosynthesis using Clark-type O2 electrodes

Sena, F.; Couture, C.; Berais-Rubio, A.; Millar, A. H.; Signorelli, S.

10.1101/2025.05.04.652138 — plant biology — Posted on 2025-05-06

5075 Phylogenetic Analysis and Machine Learning Identify Signatures of Selection and Predict Deleterious Mutations in Common Bean

Cordoba-Novoa, H. A.; Buckler, E. S.; Romay, C.; Berthel, A.; Johnson, L.; Balasubramanian, P.; Hoyos Villegas, V.

10.1101/2025.05.05.652309 — plant biology — Posted on 2025-05-06

5076 A trio-binning approach for Cannabis genome de novo assembly reveals extensive structural variation, and defines paralog cohorts with very good resolution

Pike, B.; Kozik, A.; Teran, W.

10.1101/2025.05.04.652121 — plant biology — Posted on 2025-05-06

5077 Antiviral CD4+ T and myeloid cell responses to influenza vaccines are attenuated in older adults

Oakes, J. M.; Simmons, J. D.; Hager-Nochowicz, C.; Kirk, L.; Eason, J.; Halasa, N. B.; Talbot, H. K.; Bailin, S. S.; Castilho, J. L.; Kalams, S. A.

10.1101/2025.04.30.651528 — immunology — Posted on 2025-05-06

5078 Matrix-M(R) adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

Zarnegar, B.; Carow, B.; Eriksson, J.; Spennare, E.; Öhlund, P.; Akpinar, E.; Bringeland, E.; Osterman, I. L.; Lundqvist, L.; Antti, J.; Handin, N.; Helgesson, P.-H.; Bankefors, J.; Bengtsson, K. L.; Sellin, M. E.; Palm, A.-K.; Stertman, L.; Andersson, C. L.

10.1101/2025.04.30.651498 — immunology — Posted on 2025-05-06

5079 Divergence of root system traits in soybean between breeding and diversity lines

Bogati, S.; Carpenter, J.; Jung, J.; Schafer, S. E.; Danao, J.; Woods, E.; Song, Q.; kantar, M.; Ma, J.; Wang, D. R.

10.1101/2025.05.05.651701 — plant biology — Posted on 2025-05-06

5080 A Circadian Light Regulator Controls a Core CAM Gene in the Ice Plant's C3-to-CAM Transition

Perron, N.; Le, T.; Dervinis, C.; Pereira, W. J.; Barbazuk, W. B.; Kirst, M.

10.1101/2025.05.03.652029 — plant biology — Posted on 2025-05-06

5081 Open RGB Imaging Workflow for Morphological and Morphometric Analysis of Fruits using AI: A Case Study on Almonds.

Mas-Gomez, J.; Rubio, M.; Dicenta, F.; Martinez-Garcia, P. J.

10.1101/2025.05.05.652179 — plant biology — Posted on 2025-05-06

5082 Common garden experiments suggest terpene-mediated interactions between phyllosphere microbes and Cryptomeria japonica

Ishizaki, S.; Kohyama, T. I.; Ota, Y.; Saito, T.; Suyama, Y.; Tsumura, Y.; Hiura, T.

10.1101/2025.05.04.652152 — plant biology — Posted on 2025-05-06

5083 Structural determinants for red-shifted absorption in higher-plants Photosystem I

Capaldi, S.; Guardini, Z.; Montepietra, D.; Pagliuca, V. F.; Amelii, A.; Betti, E.; John, C.; Pedraza-Gonzalez, L.; Cupellini, L.; Mennucci, B.; Bonnet, D. M. V.; Chaves-Sanjuan, A.; Dall'Osto, L.; Bassi, R.

10.1101/2025.05.05.652163 — plant biology — Posted on 2025-05-06

5084 S2-PepAnalyst: A Web Tool for Predicting Plant Small Signalling Peptides

Vomo Donfack, K. L.; Abaach, M.; Luna, A. M.; Ginot, G.; Doblas, V. G.; Morilla, I.

10.1101/2024.08.02.606319 — plant biology — Posted on 2025-05-06

5085 Consumption of clinically relevant cannabidiol doses during pregnancy alters postnatal behavior in offspring

Gomez Wulschner, L.; Chang, V. N.; Oh, W. C.; Bates, E. A.

10.1101/2025.04.30.651495 — pharmacology and toxicology — Posted on 2025-05-06

5086 Automated Joint Space Detection Improves Bone Segmentation Accuracy

Kenney, H. M.; Lichau, D.; Blanc, R.; Schnur, L.; Bell, R. D.; Ritchlin, C. T.; Schwarz, E. M.; Awad, H. A.; Wood, R. W.

10.1101/2025.04.30.651481 — pathology — Posted on 2025-05-06

5087 Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast Cancers

Pedroza, D. A.; Yuan, X.; Liu, F.; Chan, H. L.; Zhang, C.; Bowie, W.; Smith, A. J.; Calderon, S. J.; Lieu, N.; Wu, W.; Porter, P.; Sarkar, P.; Zhao, N.; Oehler, C. V.; Peller, O.; Gaber, M. W.; Zhu, Q.; perou, c.; Zhang, X.; Rosen, J.

10.1101/2025.04.30.651522 — cancer biology — Posted on 2025-05-06

5088 XVCF: Exquisite Visualization of VCF Data from Genomic Experiments

Almuneef, G.; Aljouie, A.; Bokhari, Y.; Almazroa, A.; Rashid, M.

10.1101/2025.04.30.651450 — bioinformatics — Posted on 2025-05-06

5089 SAKPE: A Site Attention Kinetic Parameters Prediction Method for Enzyme Engineering

Qiu, J.-H.; Lin, Z.; Chen, K.-W.; Sun, T.-Y.; Zhang, X.; Yuan, L.; Tian, Y.; Wu, Y.-D.

10.1101/2025.04.30.651216 — bioinformatics — Posted on 2025-05-06

5090 A new framework for evaluating model out-of-distribution for the biochemical domain

Fernandez-Diaz, R.; Hoang, T. L.; Lopez, V.; Shields, D. C.

10.1101/2024.03.14.584508 — bioinformatics — Posted on 2025-05-06

5091 IL4Pred2: Prediction of Interleukin-4 Inducing Peptides in Human and Mouse

Tomer, R.; Mehta, N. K.; Malik, S.; Jain, S.; Raghava, G. P. S.

10.1101/2025.04.23.650150 — bioinformatics — Posted on 2025-05-06

5092 StripePy: fast and robust characterization of architectural stripes

Raffo, A.; Rossini, R.; Paulsen, J.

10.1101/2024.12.20.629789 — bioinformatics — Posted on 2025-05-06

5093 The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity

Pinto, A. J.; Chouquet, A.; Bally, I.; Rossi, V.; Thielens, N. M.; Dumestre-Perard, C.; Kunert, R.; Gaboriaud, C.; Ling, W. L. W.; REISER, J.-B.

10.1101/2024.07.10.602503 — biochemistry — Posted on 2025-05-06

5094 Enzymatic carbon-fluorine bond cleavage by human gut microbes

Probst, S. I.; Felder, F. D.; Poltorak, V.; Mewalal, R.; Blaby, I. K.; Robinson, S. L.

10.1101/2024.07.15.601322 — biochemistry — Posted on 2025-05-06

5095 Hedonic foraging: From reward to action

Clemente, A.; Penacchio, O.

10.1101/2025.05.04.652128 — animal behavior and cognition — Posted on 2025-05-06

5096 Integrative Analysis of Single-cell and Bulk RNA Sequencing Reveals Macrophage Heterogeneity in Lyme Arthritis

Zhou, G.; Song, C.; Dong, Y.; Chen, Y.; Luo, Y.; Liu, M.; Zhou, Y.; Yang, Y.; Chen, X.; Liu, X.; Yang, F.; Liang, Z.; Zi, L.; Gao, H.; Cao, Z.; Gao, F.

10.1101/2025.02.14.638349 — genomics — Posted on 2025-05-06

5097 Identification of the role of SEL1L in platelet function through a multi-species genetic investigation

Dahlgren, A. R.; Careddu, F.; Norris, J. W.; Adili, R.; Kropp, E. M.; Li, Q.; Holinstat, M.; Biunno, I.; Balduini, A.; Tablin, F.; Shavit, J. A.; Finno, C. J.

10.1101/2025.04.30.651507 — genetics — Posted on 2025-05-06

5098 Chinmo is a novel regulator of differential Hippo signaling response within a single developing organ.

Tarikere, S.; Kumar, T.; Ylla, G.; Extavour, C. G.

10.1101/2025.05.02.651944 — developmental biology — Posted on 2025-05-06

5099 Neural Mechanisms of Cognitive Flexibility and Interference Control in a Stroop Task Switching Paradigm

Tahamtan, Z.; Osia, S. A.; Herman, P. A.

10.1101/2025.05.05.652181 — neuroscience — Posted on 2025-05-05

5100 Constitutive activity of the inhibitory G protein pathway mediated by non-visual opsin Opn7b reduces cFos activity in stress and fear circuits and modulates avoidance behavior

Boeke, H.; Schulte, H.; Worm, M.; Bihorac, J.; Muecher, B.; Hadamitzky, M.; Siveke, I.; Herlitze, S.; Spoida, K.

10.1101/2025.05.05.652173 — neuroscience — Posted on 2025-05-05

5101 Integrative Single-Cell Analysis of Autism Spectrum Disorder Animal Models Reveal Convergent Transcriptomic Dysregulation Involved in Excitatory-Inhibitory Imbalance and Glial Disfunction

Nani, J. V.; Duque, V. J.; Muotri, A. R.; Mecawi, A. d. S.

10.1101/2025.05.05.651905 — neuroscience — Posted on 2025-05-06

5102 Reappearing Sensory Input Guides Visual Working Memory Prioritization

Koevoet, D.; Strauch, C.; Naber, M.; Van der Stigchel, S.

10.1101/2024.02.07.579262 — neuroscience — Posted on 2025-05-06

5103 Characterization of Postsynaptic Glutamate Transporter Functionality in the Zebrafish Retinal First Synapse Across Different Wavelengths

Garbelli, M.; Niklaus, S.; Neuhauss, S. C.

10.1101/2024.08.09.607292 — neuroscience — Posted on 2025-05-06

5104 Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution

Kuo, Y.-T.; Neumann, P.; Chen, J.; Fuchs, J.; Schubert, V.; Kumke, K.; Sader, M. A.; Melzer, M.; Zhu, Z.; Himmelbach, A.; Hentrich, H.; Macas, J.; Houben, A.

10.1101/2025.05.06.652342 — evolutionary biology — Posted on 2025-05-06

5105 Cse1l Regulates Neural Crest Cell Survival and is Critical for Craniofacial and Cardiac Development

Iyyanar, P.; Stottmann, R.

10.1101/2025.05.06.652282 — developmental biology — Posted on 2025-05-06

5106 Multi-year study on the effects of elevated CO2 in mature oaks unravels subtle metabolic adjustments but stable biotic stress resistance

Sanchez-Lucas, R.; Raw, M.; Datta, A.; Hawkins, K.; Brettle, D.; Platt, E. A.; Ullah, S.; Hart, K.; Mayoral, C.; Stegner, M.; Kranner, I.; Hayward, S. A.; Pastor, V.; MacKenzie, A. R.; Luna, E.

10.1101/2025.05.03.652050 — plant biology — Posted on 2025-05-06

5107 Submersion and oxidative stress triggers pyrenoid formation, carbon concentration-related protein remodeling and sub-plastidial rearrangements in hornworts

Noetzold, S. I.; Hawat, S.; Stach, T.; Ruaud, S.; Szoevenyi, P.; Hippler, M.; Wicke, S.

10.1101/2025.05.05.652161 — plant biology — Posted on 2025-05-06

5108 A network of face patches in human prefrontal cortex for social processing of faces

Farahani, A.; Izadkhah, M.; Hamidi, R.; Yargholi, E.; Hossein-Zadeh, G.-A.; Rajimehr, R.

10.1101/2025.05.05.652210 — neuroscience — Posted on 2025-05-05

5109 The Slowest Timescales of Neural Synchronization Reveal the Strongest Influence of Auditory Distraction

Sorensen, D. O.; Sugai, J. A.; Parthasarathy, A.; Hancock, K. E.; Polley, D. B.

10.1101/2025.05.05.652235 — neuroscience — Posted on 2025-05-05

5110 Chinmo is a novel regulator of differential Hippo signaling response within a single developing organ.

Tarikere, S.; Kumar, T.; Ylla, G.; Extavour, C. G.

10.1101/2025.05.02.651944 — developmental biology — Posted on 2025-05-06

5111 The LOTUS domain of Oskar promotes localisation of both protein and mRNA components of Drosophila germ plasm

Repouliou, A.; Srouji, J. R.; Rivard, E. L.; Leschziner, A.; Extavour, C. G.

10.1101/2025.05.02.651258 — developmental biology — Posted on 2025-05-06

5112 High levels of Cdc42 GTPase underlie an all-or-none decision to fuse

Saha, S.; Sajeevan, A.; Merlini, L.; Vincenzetti, V.; Martin, S. G.

10.1101/2025.05.05.652171 — cell biology — Posted on 2025-05-06

5113 mRNA trafficking directs cell-size-scaling of mitochondria distribution and function

Bradbury, J. J.; Hulmes, G. E.; Viswanathan, R.; Costa, G.; Lovegrove, H. E.; Herbert, S. P.

10.1101/2025.05.05.652164 — cell biology — Posted on 2025-05-06

5114 Hippo-activated cells induce non-cell autonomous tumorigenesis in Drosophila

Honda, D.; Okumura, M.; Sakuma, C.; Ando, T.; Miura, M.; Chihara, T.

10.1101/2025.05.05.652237 — cell biology — Posted on 2025-05-06

5115 Vitrification-warming delays preimplantation development and impairs mitochondrial function and cytoplasmic lattices integrity in mouse embryos

Barroso, M. T.; Rodriguez Munoz, J. A.; Sjöstrom, V.; Dindini, K.; Zhao, J.; Rodriguez-Wallberg, K. A.; Palomares, A. R.

10.1101/2025.05.05.652170 — cell biology — Posted on 2025-05-06

5116 Investigating Local Negative Feedback of Rac Activity by Mathematical Models and Cell Motility Simulations

Algorta, J.; Town, J. P.; Weiner, O.; Edelstein-Keshet, L.

10.1101/2025.05.05.651928 — cell biology — Posted on 2025-05-06

5117 Differential Astrocyte-supplied NMDAR Co-Agonist for CA1 versus Dentate Gyrus Long-term Potentiation

Sateesh, S.; Abraham, W. C.

10.1101/2025.05.05.652314 — neuroscience — Posted on 2025-05-05

5118 Distinct roles of neuronal phenotypes during neurofeedback adaptation

Zhao, Y.; Stealey, H. M.; Lu, H.-Y.; Contreras-Hernandez, E.; Chang, Y.-J.; Tobler, P. N.; Santacruz, S. R.

10.1101/2025.05.02.651867 — neuroscience — Posted on 2025-05-05

5119 Dynamics of auditory word form encoding in human speech cortex

Zhang, Y.; Leonard, M. K.; Gwilliams, L.; Bhaya-Grossman, I.; Chang, E. F.

10.1101/2025.05.05.651964 — neuroscience — Posted on 2025-05-05

5120 Age-specific regulation of sociability by hypothalamic Agrp neurons

Iyilikci, O.; Kim, L.; Zimmer, M. R.; Bober, J.; Li, Y.; Pelts, M.; Santana, G. M.; Dietrich, M. O.

10.1101/2025.05.05.652061 — neuroscience — Posted on 2025-05-05

5121 Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across Species

Pizzagalli, D. A.; Treadway, M. T.; Kangas, B. D.; Romoli, B.; Breton, J.; Bruchas, M. R.; Graybiel, A. M.; Hueske, E.; Prakash, N.; Der-Avakian, A.; Berretta, S.; Bath, K. G.; Dulcis, D.

10.1101/2025.05.05.652258 — neuroscience — Posted on 2025-05-05

5122 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction

Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.

10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-05-05

5123 GEQO biosensors for absolute analyte quantification in single cells

Kuhn, S. M.; Nerli, E.; Liu, J.; Kaufmann, S.; Barahtjan, P.; Buitrango-Arango, M.; Geertsma, E. R.; Mateus, R.; Grapin-Botton, A.; Nadler, A.

10.1101/2025.05.05.652245 — cell biology — Posted on 2025-05-06

5124 TMEDs Mediate Versatile Cargo Transport in Vesicle-dependent Unconventional Secretion

Zheng, J.; Wang, H.; Sun, Y.; Chang, P.; Deng, X.; Zhang, L.; Zhu, L.; Zhu, K.; Deng, H.; Zhang, M.; Ge, L.

10.1101/2025.05.04.652080 — cell biology — Posted on 2025-05-06

5125 Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes

Erlich, I.; Douvdevany, G.; Haddad, R.; Prosser, B. L.; Kehat, I.

10.1101/2025.05.05.652192 — cell biology — Posted on 2025-05-06

5126 Lipolytic and Anti-Adipogenic Effect of Capsaicin, Camphor, and Caffeic acid on Human SGBS Adipocytes

Ali, U.; Wabitsch, M.; Gregurec, D.

10.1101/2025.05.05.652232 — cell biology — Posted on 2025-05-06

5127 Sialin2 Senses Nitrate to Activate Endosomal PI3K-AKT-NOS Signaling

Li, X.; Jiang, O.; Cao, Z.; Zhou, B.; Chen, X.; Feng, Y.; Zhang, C.; Wang, J.; Zhou, J.; Yan, R.; Chen, M.; Wang, S.

10.1101/2025.05.04.652107 — cell biology — Posted on 2025-05-06

5128 Endocytosis of a zinc transceptor ZIP4 is mediated by AP2 through an atypical dileucine motif

Wang, T.; Zhang, C.; Zhang, Y.; Hu, J.

10.1101/2025.05.03.652025 — cell biology — Posted on 2025-05-06

5129 SMG7 and eIF4A constitute a homeostatic module controlling P-body condensation and function of Meiotic bodies

Cairo, A.; Shukla, N.; Kanavorova, S.; Skalak, J.; Mikulkova, P.; Vargova, A.; Potesil, D.; Zdrahal, Z.; Hejatko, J.; Riha, K.

10.1101/2025.05.03.652043 — cell biology — Posted on 2025-05-06

5130 PKC Promotes T-Tubule Membrane Loss by Activating a PKD-NFκB Endocytic Pathway

Vilchez, A.; Pfeuffer, A.-K. M.; Wessolowski, J.; Fiegle, D. J.; Andrae, P.; Potue, P.; Kuepfer, L. K.; Shankar, T. S.; Drakos, S. G.; Selzman, C. H.; Heim, C.; Volk, T.; Seidel, T.

10.1101/2025.05.04.651469 — cell biology — Posted on 2025-05-06

5131 Biophysical and molecular mechanisms responsible for phytoplankton sinking in response to starvation

Wu, Y.; Kouadio, V. K.; Usherwood, T. R.; Li, J.; Bisher, M. E.; Aurora, R.; Lam, A. Z.; Lam, A. R.; Lytton-Jean, A. K. R.; Manalis, S. R.; Miettinen, T. P.

10.1101/2025.05.04.652135 — cell biology — Posted on 2025-05-06

5132 Effects of Tasks on Functional Brain Connectivity Derived from Inter-Individual Correlations: Insights from Regional Homogeneity of Functional MRI Data

Di, X.; Jain, P.; Biswal, B. B.

10.1101/2024.06.02.597063 — neuroscience — Posted on 2025-05-05

5133 Localized Reactivity on Protein as Riemannian Manifolds:A Geometric and Quantum-Informed Basis for Deterministic, Metal-Aware Reactive-Site Prediction

Park, H.

10.1101/2025.04.29.651260 — bioinformatics — Posted on 2025-05-05

5134 Insectivorans and Carnivorans Exhibit the Same Social Brain Relationship as Primates

Dunbar, R. I. M.; Shultz, S.

10.1101/2025.05.05.652185 — animal behavior and cognition — Posted on 2025-05-05

5135 Integrative Analysis of Single-cell and Bulk RNA Sequencing Reveals Macrophage Heterogeneity in Lyme Arthritis

Zhou, G.; Song, C.; Dong, Y.; Chen, Y.; Luo, Y.; Liu, M.; Zhou, Y.; Yang, Y.; Chen, X.; Liu, X.; Yang, F.; Liang, Z.; Zi, L.; Gao, H.; Cao, Z.; Gao, F.

10.1101/2025.02.14.638349 — genomics — Posted on 2025-05-05

5136 Rapid continuous evolution of gene libraries towards arbitrary functions

Pisera, A.; Tanoori, A.; Liu, C. C.

10.1101/2025.03.22.644768 — evolutionary biology — Posted on 2025-05-05

5137 Nuclear hormone receptor regulation of Caudal mediates ventral nerve cord assembly in C. elegans.

Noblett, N.; Roenspies, T.; Flibotte, S.; Colavita, A.

10.1101/2025.03.02.641102 — developmental biology — Posted on 2025-05-05

5138 Stress History Modulates CRF Neurons to Establish Resilience

Haynes, S. E.; Seo, H. S.; Lacagnina, A.; Morel, C.; Afzal, M. F.; Menigoz, A.; Clem, R.; Rajan, K.; Mayberg, H.; Young, L.; Han, M.-H.

10.1101/2022.08.31.505596 — neuroscience — Posted on 2025-05-05

5139 Temperature alone is not enough: food-web context determines evolutionary responses to warming

Han, Z.-Y.; Yuan, Y.; DeWitt, K.; Yammine, A.; Wieczynski, D. J.; Onishi, M.; Gibert, J. P.

10.1101/2024.05.06.592770 — ecology — Posted on 2025-05-05

5140 Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

Bracey, K.; Fye, M. A.; Cario, A.; Ho, K.-H.; Noguchi, P.; Gu, G.; Kaverina, I.

10.1101/2023.06.25.546468 — cell biology — Posted on 2025-05-05

5141 Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity

Granet, J. A.; Robertson, R.; Cusmano, A. A.; Filippelli, R. L.; Lorenz, T. O.; Li, S.; Yaqubi, M.; Stratton, J. A.; Chang, N. C.

10.1101/2024.07.24.604963 — cell biology — Posted on 2025-05-05

5142 Metabolic tagging reveals surface-associated lipoproteins in mycobacteria

Parkin, L. A.; Becker, K. L.; Maceren, J. P.; Palande, A.; Previti, M. L.; Seeliger, J. C.

10.1101/2025.01.07.631728 — microbiology — Posted on 2025-05-05

5143 Genome-directed study reveals the diversity of Salmonella T6SS effectors and identifies a novel family of lipid-targeting antibacterial toxins

Nicastro, G. G.; Sibinelli-Sousa, S.; Hespanhol, J. T.; Santos, T. W.; Munoz, J. P.; Santos, R. S.; Perez-Sepulveda, B. M.; Miyamoto, S.; Aravind, L.; de Souza, R. F.; Bayer-Santos, E.

10.1101/2024.09.27.615498 — microbiology — Posted on 2025-05-05

5144 Multiplexed smFISH reveals the spatial organization of neuropil localized mRNAs is linked to abundance

Tarannum, R.; Mun, G.; Quddos, F.; Swanger, S. A.; Steward, O.; Farris, S.

10.1101/2024.07.13.603387 — neuroscience — Posted on 2025-05-05

5145 Modular integration of neural connectomics, dynamics and biomechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegans

Kim, J.; Florman, J. T.; Santos, J. A.; Alkema, M. J.; Shlizerman, E.

10.1101/724328 — neuroscience — Posted on 2025-05-05

5146 Temperature fluctuations influence predictions of landscape-scale spruce budworm defoliation in a physiologically-informed species distribution model

Black, E. N.; Pureswaran, D. S.; Marshall, K. E.

10.1101/2024.08.19.608715 — zoology — Posted on 2025-05-05

5147 Ultra-high throughput mapping of genetic design space

O'Connell, R. W.; Rai, K.; Piepergerdes, T. C.; Wang, Y.; Brown, L. B. C.; Samra, K. D.; Wilson, J. A.; Lin, S.; Zhang, T. H.; Ramos, E.; Sun, A.; Kille, B.; Curry, K. D.; Rocks, J. W.; Treangen, T. J.; Mehta, P.; Bashor, C. J.

10.1101/2023.03.16.532704 — synthetic biology — Posted on 2025-05-05

5148 Rapid riparian ecosystem recovery in low-latitudinal North China following the end-Permian mass extinction

Guo, W.; Tian, L.; Chu, D.; Shu, W.; Benton, M.; Liu, J.; Tong, J.

10.1101/2024.11.17.624019 — paleontology — Posted on 2025-05-05

5149 Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects by RaMBat

Sun, M.; Wang, J.; Wan, S.

10.1101/2025.02.24.640010 — bioinformatics — Posted on 2025-05-05

5150 FlashFold: a standalone command-line tool for accelerated protein structure and stoichiometry prediction

Saha, C. K.; Roghanian, M.; Häussler, S.; Guy, L.

10.1101/2025.01.23.634437 — bioinformatics — Posted on 2025-05-05

5151 scRegulate: Single-Cell Regulatory-Embedded Variational Inference of Transcription Factor Activity from Gene Expression

Zandigohar, M.; Rehman, J.; Dai, Y.

10.1101/2025.04.17.649372 — bioinformatics — Posted on 2025-05-05

5152 Support for the social buffering hypothesis, especially under unpredictable precipitation regimes

Salguero-Gomez, R.; Santos, G.; Brent, L.; Gascoigne, S.; Bonsall, M. B.; Firth, J. A.; Albery, G.; Mondal, R.; Kajin, M.; Davis, K. J.

10.1101/2025.04.30.651380 — animal behavior and cognition — Posted on 2025-05-05

5153 Cuttlefish interact with multimodal 'arm wave sign' displays

Cohen Bodenes, S.; Neri, P.

10.1101/2025.04.13.648584 — animal behavior and cognition — Posted on 2025-05-05

5154 Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns

Twa, G. M.; Phillips, R. A.; Robinson, N. J.; Day, J. J.

10.1101/2024.11.29.626066 — genomics — Posted on 2025-05-05

5155 A transcontinental experiment elucidates (mal)adaptation of a cosmopolitan plant to climate in space and time

Albano, L. J.; Bastias, C. C.; Estarague, A.; Hendrickson, B. T.; Innes, S. G.; King, N.; Patterson, C. M.; Tudoran, A.; Vasseur, F.; Puentes, A.; Violle, C.; Kooyers, N. J.; Johnson, M. T.

10.1101/2024.09.16.613311 — evolutionary biology — Posted on 2025-05-05

5156 Root Contours Guided Design of a Multicellular PID Controller

Martinelli, V.; Fiore, D.; Salzano, D.; di Bernardo, M.

10.1101/2025.05.05.652201 — synthetic biology — Posted on 2025-05-05

5157 A Versatile Toolbox for Nanoscale Interrogation of Multiprotein Assemblies inside Living Cells

Felker, A.; Philippi, M.; Holtmannspötter, M.; Drees, C.; Schäfer, E.; Steinhart, M.; Kurre, R.; You, C.; Piehler, J.

10.1101/2025.04.30.651189 — biophysics — Posted on 2025-05-05

5158 Mechanistic models of asymmetric hand-over-hand translocation and nucleosome navigation by CMG helicase

Nagae, F.; Murata, Y.; Yamauchi, M.; Takada, S.; Terakawa, T.

10.1101/2025.05.05.652190 — biophysics — Posted on 2025-05-05

5159 Interplay between Rac1/RhoA and actin waves in giant epithelial cells : experiment and theory

Berthoz, R.; Li, H.; Andre, M.; Lieb, M.; Hinderling, L.; Graedel, B.; Van Unen, J.; Pertz, O.; Kruse, K.; Riveline, D.

10.1101/2025.05.02.651882 — biophysics — Posted on 2025-05-05

5160 Development of Auditory and Spontaneous Movement Responses to Music over the First Year of Life

Nguyen, T.; Bigand, F.; Reisner, S.; Koul, A.; Bianco, R.; Markova, G.; Hoehl, S.; Novembre, G.

10.1101/2025.05.04.649695 — neuroscience — Posted on 2025-05-05

5161 G-Quadruplexes Act as an On/Off Switch While i-Motifs Regulate Insulin Expression in Reporter Gene Assays

Guneri, D.; Morris, C.; Ding, Y.; Craggs, T.; Smith, S. S.; Waller, Z. A. E.

10.1101/2025.05.02.651924 — biophysics — Posted on 2025-05-05

5162 Electron bifurcation arises from emergent features of multicofactor enzymes

Wojcik-Augustyn, A.; Bujnowicz, Łukasz; Osyczka, A.; Sarewicz, M.

10.1101/2025.04.30.651465 — biophysics — Posted on 2025-05-05

5163 Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits

Kvastad, L.; Kollotzek, A.; Saghaleyni, R.; Chang, C.-F.; Cao, T.; Lappalainen, T.

10.1101/2025.05.02.651876 — genetics — Posted on 2025-05-05

5164 A gene-regulatory network model for density-dependent and sex-biased dispersal evolution during range expansions.

Deshpande, J. N.; Fronhofer, E. A.

10.1101/2023.07.18.549508 — evolutionary biology — Posted on 2025-05-05

5165 Nuclear Myosin 1 regulates platelet activation and immune response: A novel therapeutic target for hematologic disorders

Venit, T.; Khalaji, S.; Fambri, V.; Abdrobou, W.; El Gindi, M.; Shrestha, R.; Hozak, P.; Idaghdour, Y.; Teo, J.; Percipalle, P.

10.1101/2023.02.14.528461 — cell biology — Posted on 2025-05-05

5166 Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates

Lamberti, I.; Chao, J.; Gobet, C.; Naef, F.

10.1101/2025.04.30.651446 — systems biology — Posted on 2025-05-05

5167 Follistatin-like protein 1 interacts with programmed cell death 4 to promote vascular mimicry in hepatocellular carcinoma by activating the PI3K/AKT/mTOR signaling pathway

Yang, Z.; Zhu, J.; Chen, H.; Liu, J.; Li, H.; Tan, W.

10.1101/2025.04.30.651401 — cancer biology — Posted on 2025-05-05

5168 Controlling the synchronization and symmetry breaking of coupled bacterial pili on active biofilm carpets

Altin, B.; Yaman, I. Y.; Günay, E. T.; Ünlü, A.; Gediz, Y.; Gedik, N.; Karatas, B.; Basaran, M.; Kocabas, C.; Özdemir, S. K.; Kocabas, A.

10.1101/2025.05.01.651758 — biophysics — Posted on 2025-05-05

5169 Carbohydrates and the oxidative branch of the pentose phosphate pathway modify Bacteroides thetaiotaomicron phage resistance by phase variable S-layers

Fuentes, J.; Singh, S.; Pudlo, N. A.; Heaver, S.; Ley, R.; Martens, E.

10.1101/2025.05.01.651756 — microbiology — Posted on 2025-05-05

5170 MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion

Mitra, T.; Rahman, J.; Hwee, M.; Jesus Faustino Ramos, R. J.; Liu, H.; Hartman, T.; Cross, J.; de Jesus, M.; Huse, M.; Longo, V.; Zanzonico, P.; Vardhana, S. A.

10.1101/2025.04.30.651453 — immunology — Posted on 2025-05-05

5171 Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease

Hawkinson, T. r.; Liu, Z.; Ribas, R. A.; Medina, T.; Nielsen, R.; Clarke, H. A.; Ma, X.; Mueller, A.; Plasencia, A.; Shear, A.; Simpson, S.; Soto, C. M.; Sudderth, J.; Cai, F.; Cantrell, A. R.; Colpert, M. G.; Shedlock, C.; Wu, L.; Young, L. E. A.; Kooser, D. D.; chen, L.; Ryan, A. M.; Azadi, P.; Deberardinis, R. J.; Prokop, S.; Allison, D.; Huang, Y.; He, X.; Bian, J.; Vander Kooi, C. W.; Gentry, M. S.; Sun, R. C.

10.1101/2025.04.30.651461 — neuroscience — Posted on 2025-05-05

5172 Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.

Hoffner, G.; Castro, P.; Uhrig, L.; Signorelli, C. M.; Dupont, M.; Tasserie, J.; Destexhe, A.; Cofre, R.; Sitt, J.; Jarraya, B.

10.1101/2024.03.27.586806 — neuroscience — Posted on 2025-05-05

5173 Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling

Nałecz-Jawecki, P.; Roth, L.; Grabowski, F.; Li, S.; Kochanczyk, M.; Bugaj, L. J.; Lipniacki, T.

10.1101/2025.04.30.651439 — systems biology — Posted on 2025-05-05

5174 The oral microbiome and its effect on exhaled breath volatile analysis - the elephant in the room

Petralia, L. S.; Chawaguta, A.; Ruzsanyi, V.; Mayhew, C. A.; Sanders, D.

10.1101/2025.04.30.651103 — physiology — Posted on 2025-05-05

5175 Single-Shot Design of a Cyclic Peptide Inhibitor of HIV-1 Membrane Fusion with EvoBind

Daumiller, D.; Giammarino, F.; Li, Q.; Sonnerborg, A.; Cena-Diez, R.; Bryant, P.

10.1101/2025.04.30.651413 — pharmacology and toxicology — Posted on 2025-05-05

5176 Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins

Norrild, R. K.; von Bülow, S.; Halldorsson, E.; Lindorff-Larsen, K.; Rogers, J. M.; Buell, A. K.

10.1101/2024.12.21.629870 — biophysics — Posted on 2025-05-05

5177 CellAgent: LLM-Driven Multi-Agent Framework for Natural Language-Based Single-Cell Analysis

Xiao, Y.; Liu, J.; Zheng, Y.; Jiao, S.; Hao, J.; Xie, X.; Li, M.; Wang, R.; Ni, F.; Li, Y.; Wang, Z.; Shang, X.; Bao, Z.; Yang, C.; Peng, J.

10.1101/2024.05.13.593861 — bioinformatics — Posted on 2025-05-05

5178 Cheats can boost the success of a cooperative invader

Lear, L.; Buckling, A.; Hesse, E.

10.1101/2025.04.30.651436 — ecology — Posted on 2025-05-05

5179 Plant diversity shapes plant volatile emission differently at the species and community level

Medina-van Berkum, P.; Albracht, C.; Brocher, M.; Solbach, M. D.; Stein, G.; Bonkowski, M.; Buscot, F.; Heintz-Buschart, A.; Ebeling, A.; Eisenhauer, N.; El-Madany, T. S.; Huang, Y.; Kuebler, K.; Meyer, S. T.; Gershenzon, J.; Unsicker, S. B.

10.1101/2025.04.30.651392 — ecology — Posted on 2025-05-05

5180 Phased ERK function on muscle stem cell plasticity in axolotl

Yi, C.; Liu, X.; Wang, L.; Song, L.; Fei, J.-F.

10.1101/2025.04.30.650958 — developmental biology — Posted on 2025-05-05

5181 CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency

Malacaria, E.; Figlioli, C.; Palma, A.; Rinalducci, S.; Semproni, M.; Franchitto, A.; Pichierri, P.

10.1101/2022.10.08.511087 — cell biology — Posted on 2025-05-05

5182 An Aged Microenvironment Increases CAR T Cell Cytotoxicity but Impairs Therapeutic Efficacy

Kabha, M.; Rosenzweig, N.; Rakhymzhanova, a.; Atar, O.; Cohen, C. J.; Ron-Harel, N.

10.1101/2025.05.04.652106 — immunology — Posted on 2025-05-05

5183 Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship

Deery, H.; Liang, E.; Moran, C.; Egan, G. F.; Jamadar, S. D.

10.1101/2025.04.30.651418 — neuroscience — Posted on 2025-05-05

5184 In vivo directed evolution of an ultra-fast RuBisCO from a semi-anaerobic environment imparts oxygen resistance

McDonald, J. L.; Shapiro, N. P.; Mengiste, A. A.; Kaines, S.; Whitney, S. M.; Wilson, R. H.; Shoulders, M. D.

10.1101/2025.02.17.638297 — biochemistry — Posted on 2025-05-05

5185 Epinephrine Enhanced Fear Conditioning under Pentobarbital or Dexmedetomidine Anesthesia in Rats

Chen, K.-H.; Chao, S.-T.; Chang, S.-D.; Chen, D.-Y.; Liang, K.-C.

10.1101/2025.04.30.651393 — animal behavior and cognition — Posted on 2025-05-05

5186 The influence of Temperature and Relative Humidity on the Development and Survival of Laboratory-Reared Anopheles arabiensis in Ethiopia

Erana, T.; Kebede, A.; Deressa, C. T.; Yewhalaw, D.; Simma, E. A.

10.1101/2025.04.30.651405 — ecology — Posted on 2025-05-05

5187 A depositional taphonomy model for sedimentary ancient DNA based on biotic profiles of contrasting sedimentation regimes

Hansford, T. A.; Higgs, V.; Gaffney, V.; Kistler, L.; Allaby, R. G.

10.1101/2025.04.30.651409 — ecology — Posted on 2025-05-05

5188 Mucosal B cell memory selection integrates tissue-specific microbial cues via the IgA BCR

Holgado, M. P.; Origlio, S.; Bertoia, L.; Moussa, M.; Trivedi, A.; Fiore, F.; Zarubica, A.; Slack, E.; Linterman, M. A.; Cogne, M.; Gregoire, C.; GAYA, M.

10.1101/2025.04.30.651421 — immunology — Posted on 2025-05-05

5189 Langerhans Cell-targeted Protein Delivery Enhances Antigen-Specific Cellular Immune Response

Rica, R.; Klein, K.; Johnson, L.; Carta, G.; Sarcevic, M.; Langer, F.; Rademacher, C.; Wawrzinek, R.; Quattrone, F.; Sparber, F.

10.1101/2025.05.05.652195 — immunology — Posted on 2025-05-05

5190 Fifty shades of white fish: DNA barcoding reveals widespread misidentification in sushi restaurants from Southern Brazil

Almeron-Souza, F.; Tresoldi Goncalves, L.; Fagundes, N. J. R.

10.1101/2025.05.02.651977 — genetics — Posted on 2025-05-05

5191 The Nash Score and Ummartty: Quantification of Co-Evolutionary Arms Races and Evolutionary Stability for Hypothesis Testing

Remington, M.; Clark, R. W.; Hanscom, R. J.; Higham, T. E.; Sukumaran, J.

10.1101/2023.08.09.552686 — evolutionary biology — Posted on 2025-05-05

5192 Exploring sustainability through the lens of the Lotka-Volterra model in population ecology

Karjanto, N.; Peng, A.

10.1101/2025.05.01.651785 — ecology — Posted on 2025-05-05

5193 Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study

Banerjee, P.; Kuhn, J.; Pal, D. S.; Deng, Y.; Banerjee, T.; Devreotes, P. N.; Iglesias, P. A.

10.1101/2025.04.12.648264 — cell biology — Posted on 2025-05-05

5194 State and trait measures of attention predict performance in video-based learning

Madsen, J.; Parra, L. C.

10.1101/2025.05.02.651980 — neuroscience — Posted on 2025-05-05

5195 High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis

Woo, J.; Sun, Z.; Hu, Y.; Hoang, T. A.; Christine, D.; Katelyn, S.; Singhi, A.; Brand, R. E.; Chan, D. W.; Li, K.; Hruban, R. H.; Zhang, h.

10.1101/2025.05.01.651678 — cancer biology — Posted on 2025-05-05

5196 Using Bayesian priors to overcome non-identifiablility issues in Hidden Markov models

Münch, J. L.; Schmauder, R.; Paul, F.; Habeck, M.

10.1101/2024.04.20.590387 — bioinformatics — Posted on 2025-05-05

5197 mimicDetector: a pipeline for protein motif mimicry detection in host-pathogen systems

Rich, K. D.; Wasmuth, J. D.

10.1101/2025.05.02.651971 — bioinformatics — Posted on 2025-05-05

5198 Molecular surface mimicry enables CRBN to target G3BP2 for degradation

Annunziato, S.; Quan, C.; Donckele, E. J.; Lamberto, I.; Bunker, R. D.; Zlotosch, M.; Schwander, L.; Murthy, A.; Wiedmer, L.; Staehly, C.; Matysik, M.; Gilberto, S.; Kapsitidou, D.; Wible, D.; De Donatis, G. M.; Trenh, P.; SriRamaratnam, R.; Strande, V.; Almeida, R.; Dolgikh, L.; DeMarco, B.; Tsai, J.; Sadok, A.; Zarayskiy, V.; Walter, M.; Tiedt, R.; Lumb, K. J.; Bonenfant, D.; Fasching, B.; Castle, J. C.; Townson, S. A.; Gainza, P.; Petzold, G.

10.1101/2025.04.30.651496 — molecular biology — Posted on 2025-05-05

5199 Jen1 transport and endocytosis in yeast reveal pH-responsive strategies to prevent metabolites loss

Barata-Antunes, C.; Warmerdam, M.; de Hulster, E.; Ribeiro, I.; Cardoso, C.; Fernandes, V.; Leite, B.; Casal, M.; Geros, H.; Pronk, J.; Arino, J.; Mans, R.; Paiva, S.

10.1101/2024.08.01.606176 — microbiology — Posted on 2025-05-05

5200 Vascular dysfunction in Huntington's disease is located at the blood-CSF barrier and is rescued by sphingosine-1-phosphate receptor agonist

Kucharz, K.; Soylu-Kucharz, R.; Saint-Pierre, M.; Alpaugh, M.; Qvist, F.; Bjorkqvist, M.; Skotte, N. H.; Cicchetti, F.; Lauritzen, M. J.

10.1101/2025.04.30.650996 — neuroscience — Posted on 2025-05-05

5201 Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control

Messanvi, F.; Visocky, V.; Senneca, C.; Berkun, K.; Taori, M.; Bradley, S. P.; Wang, H.; Tejeda, H.; Chudasama, Y.

10.1101/2024.07.29.605653 — neuroscience — Posted on 2025-05-05

5202 Athlytics: A Computational Framework for Longitudinal Analysis of Exercise Physiology Metrics from Wearable Sensor Data

HE, Z.

10.1101/2025.05.01.651597 — bioinformatics — Posted on 2025-05-05

5203 Uncovering Convergent Cell State Dynamics Across Divergent Genetic Perturbations Through Single-Cell High-Content CRISPR Screening

Xu, Z.; Lu, Z.; Ugurbil, A.; Abdulraouf, A.; Liao, A.; Zhang, J.; Zhou, W.; Cao, J.

10.1101/2025.05.02.651939 — genomics — Posted on 2025-05-05

5204 Mutual Inhibition Model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation

Mercker, M.; Kazarnikov, A.; Tursch, A.; Richter, T.; Özbek, S.; Holstein, T. W.; Marciniak-Czochra, A.

10.1101/2021.09.13.460125 — developmental biology — Posted on 2025-05-05

5205 NR2F2 is required in the embryonic testis for Fetal Leydig Cell development

Perea-Gomez, A.; Bellido Carreras, N.; Dhellemmes, M.; Tang, F.; Le Gallo, C.; Chaboissier, M.-C.

10.1101/2024.07.17.602099 — developmental biology — Posted on 2025-05-05

5206 Modeling tissue-resident macrophage development from mouse pluripotent stem cells

Baako, A. K.; Vijayakumar, R.; Medina-Cano, D.; Wang, Z.; Romero-Pichardo, J.; Fadojutimi, K.; Do, S. C.; Lin, Y.; Islam, M. T.; Dixit, S.; Trzeciak, A.; Perry, J. S. A.; Vierbuchen, T.

10.1101/2025.05.01.651743 — developmental biology — Posted on 2025-05-05

5207 Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles

Oh, S.; Gudipati, D. R.; Shi, W.; Zhao, P.; Wu, W.; Boyington, J. C.; Nariya, H. K.; McGhee, E. G.; Azzam, T.; Raghunathan, V.; Yang, C.; Yang, C.; Lee, C.; Kim, J. D.; Zhou, T.; Mascola, J. R.; Wells, L.; Kong, R.

10.1101/2025.05.02.651772 — immunology — Posted on 2025-05-05

5208 Episodic events are flexibility encoded in both integrated and separated neural representations

Liu, Z.; Johansson, M.; Bramao, I.

10.1101/2025.04.30.651466 — neuroscience — Posted on 2025-05-05

5209 Alpha activity during verbal working memory retention depends on the stimulus presentation mode

Kosachenko, A. I.; Syttykov, D. I.; Tarasov, D. A.; Kotyusov, A. I.; Kasanov, D.; Kotchoubey, B.; Pavlov, Y. G.

10.1101/2025.05.04.652111 — neuroscience — Posted on 2025-05-05

5210 Predicting individual differences of fear and cognitive learning and extinction

Gomes, C. A.; Bach, D. R.; Razi, A.; Batsikadze, G.; Elsenbruch, S.; Engler, H.; Ernst, T. M.; Fellner, M. C.; Fraenz, C.; Genc, E.; Klass, A.; Labrenz, F.; Lissek, S.; Merz, C. J.; Metzen, D.; Nostadt, A.; Pawlik, R. J.; Penate, J. E. S.; Tegenthoff, M.; Thieme, A.; Wolf, O. T.; Gunturkun, O. E.; Quick, H.; Kumsta, R.; Timmann, D.; Spisak, T.; Axmacher, N.

10.1101/2025.05.04.651880 — neuroscience — Posted on 2025-05-05

5211 Capturing individual variation in children's oscillatory brain activity during nREM sleep

Heikkinen, V.; Merz, S.; Salmelin, R.; Vanhatalo, S.; Lauronen, L.; Liljestrom, M.; Renvall, H.

10.1101/2025.05.02.651817 — neuroscience — Posted on 2025-05-05

5212 Function of the auditory cortex characterized by its intrinsic dynamic coactivation patterns estimated in individuals

Hakonen, M.; Lankinen, K.; Kotlarz, P.; Polimeni, J. R.; Turpin, T.; Ren, J.; Wang, D.; Liu, H.; Ahveninen, J.

10.1101/2025.05.04.651766 — neuroscience — Posted on 2025-05-05

5213 From single scenes to extended scenarios: the role of the ventromedial prefrontal cortex in the construction of imagery-rich events

Taube, J.; Leelaarporn, P.; Bilzer, M.; Stirnberg, R.; Sagik, Y.; McCormick, C.

10.1101/2025.05.03.652053 — neuroscience — Posted on 2025-05-05

5214 In sync with sound: Interpersonal synchronization as an objective measure of listening engagement

Lambrechts, L.; Accou, B.; Vanthornhout, J.; Boets, B.; Francart, T.

10.1101/2025.02.26.639799 — neuroscience — Posted on 2025-05-05

5215 Holistic Motor Control of Zebra Finch Song Syllable Sequences

Trusel, M.; Zuo, J.; Alam, D.; Marks, E. S.; Koch, T. M. I.; Cao, J.; Pancholi, H.; Cooper, B. G.; Zhang, W.; Roberts, T. F.

10.1101/2025.05.04.652139 — neuroscience — Posted on 2025-05-05

5216 Characterisation of putative retrotrapezoid nucleus (RTN) chemoreceptor neurons in the adult human brainstem

Liu, Y.; Machaalani, R.; Markus, I.; Shepherd, C. E.; Kumar, N. N.

10.1101/2025.04.30.650987 — neuroscience — Posted on 2025-05-05

5217 TDP-43 toxic gain of function links ALS, FTD and Alzheimer's Disease through splicing dysregulation

Van Zuiden, W.; Meimoun, T. D.; Bar, C.; Siany, A.; Moshe, L.; Yacovzada, N. S.; Weizman, E.; Neumann, M.; Buchman, A. S.; Wang, Y.; Bennett, D. A.; Glass, J. D.; Trautwig, A. N.; Seyfried, N. T.; Cooper-Knock, J.; Hornstein, E.

10.1101/2025.04.20.648873 — neuroscience — Posted on 2025-05-05

5218 Development and Validation of a Stem Cell-Based Kidney Organoid Platform for Nephrotoxicity Assessment

Nakanoh, H.; Tsuji, K.; Uchida, N.; Fukushima, K.; Haraguchi, S.; Kitamura, S.; Wada, J.

10.1101/2025.04.30.651410 — pharmacology and toxicology — Posted on 2025-05-05

5219 Gap scheduling of a PARP inhibitor and nanoparticle TOP1 agent combination avoids synergistic bone marrow toxicity

Oplustil O'Connor, L.; Wang, A.; Sadler, C.; Barnes, J.; Odedra, R.; Smith, A.; Hughes, G.; Lau, A.; Tellez, A.; Eliasof, S.; Cadogan, E.; O'Connor, M. J.

10.1101/2025.04.30.651268 — cancer biology — Posted on 2025-05-05

5220 Inhibition of MLLT1 limits growth of MLL-AF4 leukaemias without killing healthy haematopoietic stem cells

Rajhansa, S.; Crump, N. T.; Khoo, H. M.; Bozhilov, Y.; Brennan, P. E.; Fedorov, O.; Adams, C.; Farnie, G.; Milne, T. A.; Wilkinson, A. C.

10.1101/2025.04.30.651417 — cancer biology — Posted on 2025-05-05

5221 Binding of extracellular vesicles to stretched von Willebrand factor promotes platelet activation

Wang, Y.; Liu, X.; Downar, T.; Topuz, A.; Bauer, A. T.; Brenna, S.; Bendas, G.; Puig, B.; Schneider, S. W.; Fedosov, D.; Gorzelanny, C.

10.1101/2025.04.30.650971 — cancer biology — Posted on 2025-05-05

5222 PyCycleBio: modelling non-sinusoidal-oscillator systems in temporal biology

Bennett, A. R.; Birchenough, G.; Bojar, D.

10.1101/2025.04.30.651403 — bioinformatics — Posted on 2025-05-05

5223 Limits of deep-learning-based RNA prediction methods

Ludaic, M.; Elofsson, A.

10.1101/2025.04.30.651414 — bioinformatics — Posted on 2025-05-05

5224 Computational design of conformation-biasing mutations to alter protein functions

Cavanagh, P. E.; Xue, A. G.; Dai, S.; Qiang, A.; Matsui, T.; Ting, A. Y.

10.1101/2025.05.03.652001 — biophysics — Posted on 2025-05-05

5225 Athlytics: A Computational Framework for Longitudinal Analysis of Exercise Physiology Metrics from Wearable Sensor Data

HE, Z.

10.1101/2025.05.01.651597 — bioinformatics — Posted on 2025-05-05

5226 Replication stress underlies genomic instability at CTCF/cohesin-binding sites in cancer

Faseela, E. E.; Notani, D.; Sabarinathan, R.

10.1101/2023.10.24.563697 — genomics — Posted on 2025-05-05

5227 The dynamics of coexistence and succession in a decaying ecosystem

Kalirad, A.; Theam, P.; Sommer, R. J.

10.1101/2025.04.28.650976 — ecology — Posted on 2025-05-05

5228 A single cell ATAC-seq atlas uncovers dynamic changes in chromatin accessibility during cell fate specification at the neural plate border

Harmrud, E.; Leese, J.; Thiery, A. P.; Buzzi, A. L.; Vigilante, A.; Briscoe, J.; Streit, A.

10.1101/2025.05.03.652017 — developmental biology — Posted on 2025-05-05

5229 A light-modulated clock mechanism in a hydrozoan jellyfish that synchronises evening gamete release.

Kitsui, R.; Takeda, N.; Deguchi, R.; Houliston, E.; Momose, T.

10.1101/2025.05.05.651927 — developmental biology — Posted on 2025-05-05

5230 Quantification of horizontal and vertical distribution of junctional proteins in fixed epithelial cells

Lovejoy, M.; Mucci, A.; Rabino, A.; Garcia-Mata, R.

10.1101/2025.05.01.651687 — cell biology — Posted on 2025-05-05

5231 Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

Teleman, A. A.; Roiuk, M.; Neff, M.

10.1101/2024.11.20.624465 — molecular biology — Posted on 2025-05-05

5232 Carbohydrates and the oxidative branch of the pentose phosphate pathway modify Bacteroides thetaiotaomicron phage resistance by phase variable S-layers

Singh, S.; Pudlo, N. A.; Heaver, S.; Ley, R.; Martens, E.; Fuentes, J.

10.1101/2025.05.01.651756 — microbiology — Posted on 2025-05-05

5233 Computational modelling shows evidence in support of both sensory and frontal theories of consciousness

Bandara, K. H.; Rowe, E. G.; Garrido, M. I.

10.1101/2024.11.02.621640 — neuroscience — Posted on 2025-05-05

5234 Generating Synthetic Task-based Brain Fingerprints for Population Neuroscience Using Deep Learning

Serin, E.; Ritter, K.; Schumann, G.; Banaschewski, T.; Marquand, A.; Walter, H.

10.1101/2024.08.03.606469 — neuroscience — Posted on 2025-05-05

5235 Orofacial movements: Individuality and stereotypy when mice move a single whisker to touch

Staab, M.; Sehara, K.; Bahr, N.; Dominiak, S.; Larkum, M.; Sachdev, R.

10.1101/2022.10.03.510596 — neuroscience — Posted on 2025-05-05

5236 High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis

Woo, J.

10.1101/2025.05.01.651678 — cancer biology — Posted on 2025-05-05

5237 Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis

Nissen, I.; Dakhel, S.; Chakraborty, C.; Nygaard, A. H.; Kirkeby, A.; Hornblad, A.; Erdem, C.; Remeseiro, S.

10.1101/2025.04.30.651564 — genomics — Posted on 2025-05-05

5238 Co-mutation based genetic networks to infer temporal mutation dynamics in ancient human mitochondrial genomes

Verma, R. K.; Fuentes-Gonzalez, J.; Pienaar, J.; Fierst, J. L.

10.1101/2025.05.02.651746 — evolutionary biology — Posted on 2025-05-05

5239 Sialin2 Functions as a Mammalian Nitrate Sensor to Sustain Mitochondrial Homeostasis

Li, X.; Wu, S.; Cao, Z.; Jiang, O.; Li, S.; Chen, X.; Feng, Y.; Zhou, B.; Zhang, C.; Xiao, G.; Wang, J.; Zhou, J.; Chen, M.; Yan, R.; Wang, S.

10.1101/2025.05.04.652104 — cell biology — Posted on 2025-05-05

5240 Pharmacological restoration of deficits in mitochondrial trafficking rescues aberrant axonal activity in tauopathy

Sabec, M. H.; Adam, O.; Ashby, M. C.

10.1101/2025.05.02.651902 — neuroscience — Posted on 2025-05-05

5241 Compensating Cortical Thickness for Cortical Folding-Related Variation

Demirci, N.; Coalson, T. S.; Holland, M. A.; Van Essen, D. C.; Glasser, M. F.

10.1101/2025.05.03.651968 — neuroscience — Posted on 2025-05-05

5242 Recycling of prefrontal subspaces dynamically multiplexes information

Wentz, P. T.; Brincat, S. L.; Pasupathy, A.; Miller, E. K.

10.1101/2025.05.02.651965 — neuroscience — Posted on 2025-05-05

5243 Hippocampal-prelimbic coupling during context-dependent extinction retrieval in rats

Mourao, F.; Totty, M. S.; Tuna, T.; Maren, S.

10.1101/2025.05.03.652056 — neuroscience — Posted on 2025-05-05

5244 Empowering multitrait brain phenotypes GWAS

Auvergne, A.; Traut, N.; Julienne, H.; Frouin, A.; Toro, R.; Aschard, h.

10.1101/2025.05.04.652120 — neuroscience — Posted on 2025-05-05

5245 Afferent-specific modulation of excitatory synaptic transmission by acetylcholine and serotonin in the prelimbic cortex

Baker, A. L.; Gulledge, A. T.

10.1101/2025.05.04.652144 — neuroscience — Posted on 2025-05-05

5246 Enhanced axonal transport in large vertebrates: KIF5A adaptations in giraffes and pythons

Kambara, T.; Rao, L.; Yamagishi, Y.; Ikeda, K.; Taniguchi, D.; Imasaki, T.; Shigematsu, H.; Sakai, N.; Gennerich, A.; Nitta, R.; Okada, Y.

10.1101/2025.05.04.652084 — biophysics — Posted on 2025-05-05

5247 Plastic-elastomer heterostructure for robust flexible brain-computer interfaces

Lin, X.; Zhang, X.; Wang, Z.; Chen, J.; Lee, J.; Lee, A. J.; Yang, H.; Remy, A.; Shen, H.; He, Y.; Zhao, H.; Zhang, X.; Wang, W.; Aljovic, A.; Vlassak, J. J.; Lu, N.; Liu, J.

10.1101/2025.04.29.651325 — bioengineering — Posted on 2025-05-04

5248 Exercise training remodels inter-organ endocrine networks

Ahn, C.; Hevener, A. L.; Goodyear, L. J.; Bodine, S. C.; Esser, K. A.; Seldin, M. M.; Sparks, L. M.

10.1101/2025.04.29.651323 — physiology — Posted on 2025-05-04

5249 Quantification of single cell-type-specific alternative transcript initiation

Fu, S.; Wilson, P.; Zhang, B.

10.1101/2025.04.29.651292 — bioinformatics — Posted on 2025-05-04

5250 Gene-based calibration of high-throughput functional assays for clinical variant classification

Zeiberg, D.; Tejura, M.; McEwen, A. E.; Fayer, S.; Pejaver, V.; Rubin, A. F.; Starita, L. M.; Fowler, D. M.; O'Donnell-Luria, A.; Radivojac, P.

10.1101/2025.04.29.651326 — bioinformatics — Posted on 2025-05-04

5251 Optimizing cardiac organoid culture to enhance maturation, viability, and cardiotoxicity assessments

Harihara, A.; Moshksayan, K.; Momtahan, N.; Ben-Yakar, A.; Zoldan, J.

10.1101/2025.04.29.651308 — bioengineering — Posted on 2025-05-04

5252 A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells

Duggal, G.; Pettingill, P.; Lalic, T.; Gupta, S. K.; Hogsbro, C. F.; Volpato, V.; Webber, C.; Bowden, R.; Charou, D.; Arunasalam, K.; Li, X.; Maresca, M.; Hicks, R.; Chintawar, S.; Cader, Z.

10.1101/2025.04.29.651263 — neuroscience — Posted on 2025-05-04

5253 The Brain, Body, and Behavior Dataset (BBBD): Multimodal Recordings during Educational Videos

Madsen, J.; Kuppa, N.; Parra, L. C.

10.1101/2025.04.29.651259 — neuroscience — Posted on 2025-05-04

5254 Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures

Tentori, E.; Kastellakis, G.; Maschietto, M.; Leparulo, A.; Poirazi, P.; Mazzucato, L.; Allegra, M.; Vassanelli, S.

10.1101/2025.04.29.651327 — neuroscience — Posted on 2025-05-04

5255 A combined neuroanatomy, ex vivo imaging and immunohistochemistry defined MRI mask for the human paraventricular nucleus of the thalamus

Tetzlaff, M. R.; Leonard, B. T.; Yassa, M. A.; Baram, T. Z.; Rasmussen, J. M.

10.1101/2025.04.29.651339 — neuroscience — Posted on 2025-05-04

5256 Adolescent intermittent ethanol exposure induces sex-specific and time-dependent changes in affective behaviors and metabolomic profiles.

Shobande, M. J.; Kumari, A.; Pearson, M.; Baker, J. A.; Hall, N. I.; Waters, R. C.; Emehel, C. E.; Hill, D.; Fowlkes, M. E.; Dean, T.; Cannady, R.; Wang, B.; Maldonado-Devincci, A. M.

10.1101/2025.04.29.651256 — neuroscience — Posted on 2025-05-04

5257 TBK1 eliminates aggregation-prone monomeric TDP-43 through the IFNβ-immunoproteasome pathway

Sakai, S.; Oiwa, K.; Iguchi, Y.; Watanabe, S.; Komine, O.; Horiuchi, M.; Katsuno, M.; Yamanaka, K.

10.1101/2025.04.29.650889 — neuroscience — Posted on 2025-05-04

5258 Association between high-frequency hearing sensitivity and visual cross-modal plasticity in typical-hearing adults

Paul, B. T.; Srikanthanathan, A.; Daien, M.; Dimitrijevic, A.

10.1101/2025.04.28.648945 — neuroscience — Posted on 2025-05-04

5259 A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors.

Gardam, B.; Nam, E.; Kollis, P. M.; Kilyen-Coles, J.; Lenin, S.; Gliddon, B. L.; Tea, M. N.; Pitson, S. M.; Brown, M. P.; Ebert, L. M.; Gargett, T.

10.1101/2025.04.29.651335 — cancer biology — Posted on 2025-05-04

5260 Reprogramming breast cancer cells to breast cancer stem cell-like by the POU1F1 transcription factor

Concepcion, L. A.; Ruzo, S. S.; Gonzalez, S. R.; Gois, M.; Arias, M. E.; Delgado, D. M.; Lado, N.; Caballero, T. G.; Aguiar, P.; Fernandez, R. P.

10.1101/2025.04.30.651395 — cancer biology — Posted on 2025-05-04

5261 The Liver-Enriched Long Non-Coding RNA FAM99A Suppresses Tumorigenesis through Negative Regulation of Protein Synthesis

Sarfaraz, N.; Kaur, R.; Harper, S.; Oni, L.; Somarowthu, S.; Bouchard, M. J.

10.1101/2025.04.29.651319 — cancer biology — Posted on 2025-05-04

5262 Localized Reactivity on Protein as Riemannian Manifolds:A Geometric and Quantum-Informed Basis for Deterministic, Metal-Aware Reactive-Site Prediction

Park, H.

10.1101/2025.04.29.651260 — bioinformatics — Posted on 2025-05-04

5263 MIST-Explorer: The Comprehensive Toolkit for Spatial Omic Analysis and Visualization of Single-Cell MIST Array Data

Fischer, C.; Chen, J.; Meah, A.; Wang, J.

10.1101/2025.04.29.650640 — bioinformatics — Posted on 2025-05-04

5264 Continuous Monitoring of Head Turns: Compliance, Kinematics, and Reliability of Wearable Sensing

Cho, S. Y.; Dibble, L. E.; Fino, P. C.

10.1101/2025.04.29.650670 — bioengineering — Posted on 2025-05-04

5265 Development of an Open-source Low-cost Pressure Myography and Cardiac Flow Simulator, HemoLens, for Mechanical Characterization of Native and Engineered Blood Vessels

PereiraTavares, A. J.; Aranda-Michel, L.; Hahn, S. A.; Coffin, B. D.; Ashraf, S. F.; Szafron, J. M.; Straub, A. C.; Shiwarski, D. J.

10.1101/2025.04.29.651300 — bioengineering — Posted on 2025-05-04

5266 Hybrid NMR-Computational framework for Mapping Functional Hot Spots and Guiding Directed Evolution of large Enzymes

Chen, Y.; Gong, Z.; Zhao, X.; Zhu, M.; Raza, A.; Tao, Z.; Li, W.; Zhang, X.; Liu, M.; He, L.

10.1101/2025.03.12.642771 — molecular biology — Posted on 2025-05-04

5267 Human biliary atresia extrahepatic cholangiocyte organoids express increased ER and oxidative stress, altered drug metabolism and cell polarity changes

Har-Zahav, A.; Hamody, Y.; Danan, K.; Tobar, A.; Basphelchik, M.; Gurevich, M.; Shamir, R.; Gat-Viks, I.; Waisbourd-Zinman, O.

10.1101/2025.05.04.649927 — molecular biology — Posted on 2025-05-04

5268 Context-Dependent Synergism and Antagonism between IGF2BP1/3 and METTL3/14 in m6A-mediated mRNA regulation

Bhardwaj, R.; Bhakhri, H.; Palanichamy, J. K.

10.1101/2025.05.04.652102 — molecular biology — Posted on 2025-05-04

5269 Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats

Delorme, T. C.; Sambare, S.; Williams, B. R.; Gamble, M. C.; Solberg-Woods, L.; Maturin, L.; Palmer, A. A.; George, O.; Logan, R.

10.1101/2025.04.29.651331 — neuroscience — Posted on 2025-05-04

5270 Haptic Force Feedback Enhances de Novo Learning of Arm Kinematics and Dynamics

Howard, I. S.; Alvarez-Hidalgo, L.

10.1101/2025.04.29.651298 — neuroscience — Posted on 2025-05-04

5271 When Meaning Matters Most: Rethinking Cloze Probability in N400 Research

Arkhipova, Y.; Lopopolo, A.; Vasishth, S.; Rabovsky, M.

10.1101/2025.04.29.651301 — neuroscience — Posted on 2025-05-04

5272 Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis during Drosophila development.

Silva, V.; Scott, R.; Guajardo, P.; Luan, H.; Herzog, R.; White, B. H.; Ewer, J.

10.1101/2025.04.03.646974 — neuroscience — Posted on 2025-05-04

5273 The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques

Howell, A. M.; Warrington, S.; Fonteneau, C.; Cho, Y. T.; Sotiropoulos, S.; Murray, J. D.; Anticevic, A.

10.1101/2023.07.22.550168 — neuroscience — Posted on 2025-05-04

5274 Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution in vivo MRI from the Hippocampal Subfields Group (HSG)

Daugherty, A. M.; Carr, V.; Canada, K.; Radman, G.; Brown, T.; Augustinack, J.; Amunts, K.; Bakker, A.; Berron, D.; Burggren, A.; Chetelat, G.; de Flores, R.; Ding, S.-L.; Huang, Y.; Insausti, R.; Johnson, E.; Kanel, P.; Keresztes, A.; Kedo, O.; Kennedy, K. M.; Lee, J.; Malykhin, N.; Martinez, A.; Mueller, S.; Mulligan, E.; Ofen, N.; Palombo, D.; Pasquini, L.; Pluta, J.; Raz, N.; Riggins, T.; Rodrigue, K. M.; Saifullah, S.; Schlichting, M. L.; Stark, C.; Wang, L.; Yushkevich, P.; La Joie, R.; Wisse, L.; Olsen, R.; the Alzheimers Disease Neuroimaging Initiative, ; the Hippocampal Subfields Gro

10.1101/2025.04.29.651039 — neuroscience — Posted on 2025-05-04

5275 Task-specificity of local load feedback depends on intersegmental information in an insect walking system

Ruthe, A.; Oezyer, A.; Akay, T.; Bueschges, A.

10.1101/2025.04.29.651003 — neuroscience — Posted on 2025-05-04

5276 Changes in Higuchi's fractal dimension across age in healthy human EEG are anti-correlated with changes in oscillatory power and 1/f slope

Aggarwal, S.; Ray, S.

10.1101/2024.06.15.599168 — neuroscience — Posted on 2025-05-04

5277 Design of a Modular Inducible Circuit for Pulsatile Population Control of Engineered Bacteria

Roy, R.; Mayalu, M. N.

10.1101/2025.05.03.652077 — synthetic biology — Posted on 2025-05-04

5278 Ketone body mediated histone β-hydroxybutyrylation is reno-protective

Mandal, J.; Aryal, S.; Manandhar, I.; Chakraborty, S.; Mei, X.; Yeoh, B. S.; Mell, B.; Kleinhenz, A.; Tummala, R.; Yang, T.; Saha, P.; Gunning, W. T.; Vijay-Kumar, M.; Basrur, V.; de la Serna, I.; Joe, B.

10.1101/2024.12.18.628574 — physiology — Posted on 2025-05-04

5279 G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

Fuchs, H. A.; Peng, Y.; Ayyappan, S.; Zhang, H.; Rosas, R.; Panchenko, A.; Musselman, C. A.

10.1101/2025.05.02.651932 — biophysics — Posted on 2025-05-04

5280 Prediction of fast subcellular calcium signals based on label-free second harmonic generation microscopy measurements

Georgiev, T.

10.1101/2023.04.03.535276 — bioinformatics — Posted on 2025-05-04

5281 Predicting microbial transcriptome using genome sequence

FU, G.; YAN, Y.; CHEN, Y.; SHAO, B.

10.1101/2024.12.30.630741 — bioinformatics — Posted on 2025-05-04

5282 AI-assisted Drug Re-purposing for Human Liver Fibrosis

GUAN, Y.; Inchai, J.; Fang, Z.; Law, J.; Brito, A. A. G.; Pawlosky, A.; GottWeis, J.; Daryin, A.; Myaskovsky, A.; Palepu, A.; Rong, k.; Xu, Y.; Tu, T.; Peltz, G.

10.1101/2025.04.29.651320 — bioinformatics — Posted on 2025-05-04

5283 Bacteriophage-Loaded Microneedle Patches for Targeted andMinimally Disruptive Foodborne Pathogen Decontamination

Prasad, A.; Khan, S.; Arshad, F.; Sidhu, H.; Jackson, K.; MacLachlan, R.; Kvitka, E.; Grignano, V.; Mann, H.; Filipe, C.; Hosseinidoust, Z.; Didar, T.

10.1101/2025.04.30.651002 — bioengineering — Posted on 2025-05-04

5284 How Electric Field Controls the Hydration and Fibrillar Structure of Self-Assembling Aminopolysaccharides

Romany, A.; Payne, G. F.; Shen, J.

10.1101/2025.04.25.650622 — bioengineering — Posted on 2025-05-04

5285 Evaluation of Nanopore direct RNA sequencing updates for modification detection

Esfahani, N. G.; Stein, A. J.; Akeson, S.; Tzadikario, T.; Jain, M.

10.1101/2025.05.01.651717 — genomics — Posted on 2025-05-04

5286 Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans

Comerford, M.; Vespasiani, D. M.; Shukla, N.; Cook, L. E.; Yermakovich, D.; Dannemann, M.; Leavesley, M.; Kinipi, C.; Ricaut, F.-X.; Brucato, N.; Cox, M. P.; Gallego Romero, I.

10.1101/2025.05.04.652069 — evolutionary biology — Posted on 2025-05-04

5287 CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder

Ghandour, T.; Glausier, J. R.; Asok, A.; Doyle, M. R.; Campo, P.; Colnaghi, L.; Lewis, D. A.; Kandel, D. B.; Kandel, E. R.; de Guglielmo, G.; Huang, S.-s. C.; Melas, P. A.

10.1101/2025.05.04.652083 — molecular biology — Posted on 2025-05-04

5288 cctbx.xfel: a suite for processing serial crystallographic data

Brewster, A. S.; Paley, D. W.; Bhowmick, A.; Mittan-Moreau, D. W.; Young, I. D.; Mendez, D.; Tchon, D. M.; Poon, B. K.; Sauter, N. K.

10.1101/2025.05.04.652045 — molecular biology — Posted on 2025-05-04

5289 Acidification by nitrogen metabolism triggers extracellular biopolymer production in an oleaginous yeast

Sepulveda Del Rio Hamacek, H.; Tingajeva, O.; Ostertag, K.; Rekena, A.; Illarionov, A.; Joul, P.; Monteiro de Oliveira, P.; de La Caridad Martin-Hernandez, G.; Müller, B.; Bonturi, N.; Passoth, V.; Lahtvee, P.-J.; Kumar, R.

10.1101/2025.05.04.652101 — microbiology — Posted on 2025-05-04

5290 Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity

Maldonado, J. S.; Sepulveda, S.; Karthikeyan, S.; Shirakawa, K. T.; Merced, I.; Radecki, A. A.; Douglas, J.; Peti, W.; Page, R.; Vargas-Rodriguez, O.

10.1101/2025.05.04.652006 — biochemistry — Posted on 2025-05-04

5291 Support for the social buffering hypothesis, especially under unpredictable precipitation regimes

Salguero-Gomez, R.; Santos, G.; Brent, L.; Gascoigne, S.; Bonsall, M. B. F.; Firth, J. A.; Albery, G.; Mondal, R.; Kajin, M.; Davis, K. J.

10.1101/2025.04.30.651380 — animal behavior and cognition — Posted on 2025-05-04

5292 Bridging Hearts and Muscles: Genetic Insights into Cardiac Structure and Sarcopenia

Wang, C.; Xie, W.; Zhu, Y.; Liu, Z.; Yang, G.; Zhong, D.; Li, Y.; Zhao, S.

10.1101/2025.04.29.651359 — genetics — Posted on 2025-05-04

5293 CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization

Kovacs, B.; Somogyi, F.; Szabo, V.; Nagy, Z. Z.; Hernadi, I.; Matyas, F.; Vanduffel, W.; Szemlaky, Z.; Rozsa, B.; Ulbert, I.; Hillier, D.

10.1101/2025.04.30.651383 — immunology — Posted on 2025-05-04

5294 Virus glycoprotein nanodisc platform for vaccine design

Rantalainen, K.; Liguori, A.; Ozorowski, G.; Flynn, C.; Steichen, J. M.; Swanson, O.; Madden, P. J.; Baboo, S.; Phulera, S.; Gharpure, A.; Lu, D.; Kalyuzhniy, O.; Skog, P.; Terada, S.; Shil, M.; Diedrich, J. K.; Georgeson, E.; Tingle, R.; Eskandarzadeh, S.; Lee, W.-H.; Goodwin, D.; Alavi, N.; Kubitz, M.; Amirzehni, S.; Himansu, S.; Sok, D.; Lee, J. H.; Yates, J. R.; Paulson, J. C.; Crotty, S.; Schiffner, T.; Ward, A. B.; Schief, W. R.

10.1101/2025.05.02.651272 — immunology — Posted on 2025-05-04

5295 Engineering sialylation in pigs: A promising strategy for overcoming xenograft rejection and revolutionizing organ transplantation.

Roy, S.; Rao, C.; Sims, E. K.; Bottino, R.; Cooper, D.; Piganelli, J. D.

10.1101/2025.04.30.651299 — immunology — Posted on 2025-05-04

5296 Factors Influencing Monoclonal Antibody Pharmacokinetics Across Varying Immune Perturbations

DeBonis, J.; Davis, A.; Wang, Z.; Fell, C.; Diehl, M.; Igoshin, O. A.; Veiseh, O.

10.1101/2025.04.29.651349 — immunology — Posted on 2025-05-04

5297 Housing environment bilaterally alters transcriptomic profile in the rat hippocampal CA1 region

Kubota, A.; Kojima, K.; Koketsu, S.; Kannon, T.; Sato, T.; Hosomichi, K.; Shinohara, Y.; Tajima, A.

10.1101/2025.04.29.651351 — neuroscience — Posted on 2025-05-04

5298 Rapid hypothalamic-pituitary recovery after chronic glucocorticoid therapy enables strategies that prevent adrenal suppression

Gaston, L. S.; Jorgensen, B. C.; Friedman, H. R.; Sherman, M. S.; Majzoub, J. A.

10.1101/2025.04.30.651350 — physiology — Posted on 2025-05-04

5299 Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth

Ma, Y.; Ayadhury, S.; Singh, S.; Vashishath, Y.; Ozdemir, C.; McKee, T.; Nguyen, N.; Basi, A.; Mak, D.; Gomez, J.; Huse, J.; Noor, S.; Winkowski, D.; Baird, R.; Weinberg, J.; Lang, F.; Burks, J.; Bozdag, S.; Seeley, E.; Ene, C.

10.1101/2025.04.30.651361 — cancer biology — Posted on 2025-05-04

5300 Effects of a Cancer-Associated Mutation and Multiple SerinePhosphorylation on Poly(ADP-Ribose) Polymerase 2

Ghafari, M.; Cisneros, G. A.; Chatterjee, S.; Hughes, B.

10.1101/2025.04.29.651341 — biophysics — Posted on 2025-05-04

5301 Understanding the physical processes behind DNA-DNA proximity ligation assays

Zubillaga Herrera, B. J.; Das, A.; Burack, L. R.; Wang, A.; Di Pierro, M.

10.1101/2025.05.02.649190 — biophysics — Posted on 2025-05-04

5302 Genome-wide expression gradient estimation based on local pseudotime in single cell RNA sequencing

Tjaernberg, A.; Jackson, C.; Bonneau, R.; Christiaen, L.

10.1101/2025.05.01.650773 — bioinformatics — Posted on 2025-05-04

5303 Postoperative Stress Accelerates Atherosclerosis through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Boucher, D. M.; Rochon, V.; Laval, T.; Lorant, V.; Carter, A.; Emerton, C.; Joyce, N.; Vinayak, N.; Scaffidi, M.; Auer, R. C.; Gordon, S. M.; Ouimet, M.

10.1101/2025.05.02.651357 — biochemistry — Posted on 2025-05-04

5304 Understanding the population structure of Moraxella catarrhalis using core genome multilocus sequence typing (cgMLST) and a life identification number (LIN) code classification system

Yassine, I.; Jolley, K. A.; Bray, J. E.; Jansen van Rensburg, M. J.; Patel, F.; Sheppard, A. E.; Zar, H. J.; Allen, V.; Ah Tow, L.; Maiden, M. C. J.; Nicol, M. P.; Brueggemann, A. B.

10.1101/2025.04.30.651387 — genomics — Posted on 2025-05-04

5305 Predicting forest tree leaf phenology under climate change using satellite monitoring and population-based GWAS

Pfenninger, M.; Langan, L.; Feldmeyer, B.; Eberhardt, L.; Reuss, F.; Hofmann, J.; Fussi, B.; Seho, M.; Mellert, K.-H.; Hickler, T.

10.1101/2025.04.30.651385 — evolutionary biology — Posted on 2025-05-04

5306 Context-Dependent Adaptation in Structured Environments

Karita, Y.; Rodriguez-Sanchez, G. T.; Brambilla, E.; Hernandez-Beltran, J. C. R.; Schwarz, M.; Rainey, P. B.

10.1101/2025.04.29.651346 — evolutionary biology — Posted on 2025-05-04

5307 Convergent pathways of reductive mitochondrial evolution characterised with hypercubic inference

Glastad, R. C.; Johnston, I.

10.1101/2025.04.29.651065 — evolutionary biology — Posted on 2025-05-04

5308 No association between metabolic rate and an exaggerated sexually selected trait

Matsumura, K.; Noda, T.; Sharma, M. D.; Okada, K.; Miyatake, T.; Hosken, D. J.

10.1101/2025.04.29.651352 — ecology — Posted on 2025-05-04

5309 A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine

Tang, X.-L.; Alloosh, M.; Ou, Q.; Luo, L.; Agrawal, D. K.; Kalra, D. K.; Sturek, M.; Bolli, R.

10.1101/2025.04.29.651284 — developmental biology — Posted on 2025-05-04

5310 G2VTCR: predicting antigen binding specificity by Weisfeiler-Lehman graph embedding of T cell receptor sequences

Wang, Z.; Shen, Y.

10.1101/2025.04.29.651344 — immunology — Posted on 2025-05-04

5311 Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel genomically humanised SOD1A4V mice.

Thompson, D.; Williams, C.; Tosolini, A. P.; Gilthorpe, J.; Schiavo, G.; Fisher, E. M.; Cunningham, T. J.

10.1101/2025.05.01.650597 — neuroscience — Posted on 2025-05-04

5312 Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety

Mourra, D.; Murphy, C. E.; Hourany, E.; Centeno, K.; Gnazzo, F.; Beeler, J. A.

10.1101/2025.04.29.651295 — neuroscience — Posted on 2025-05-04

5313 Identifying Explainable and Generalizable Features for MEG Decoding

Maleki, N.; Karimi-Rouzbahani, H.

10.1101/2025.04.30.651376 — neuroscience — Posted on 2025-05-04

5314 PEtab.jl: Advancing the Efficiency and Utility of Dynamic Modelling

Cvijovic, M.; Persson, S.; Frohlich, F.; Grein, S.; Lomna, T.; Ognissanti, D.; Hassselgren, V.; Hasenauer, J.

10.1101/2025.04.30.651378 — systems biology — Posted on 2025-05-04

5315 Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia

Ahn, B.; Wanagat, J.; Cleary, C.; Ainsworth, H. C.; Kim, E.; Kim, H.

10.1101/2025.04.29.649515 — physiology — Posted on 2025-05-04

5316 Profiling of HCAR1 signaling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist

Lind, S.; Wright, S. C.; Gvozdenovic, E.; Nilsson, K. A.; Granberg, K. L.; Bouvier, M.; Johansson, L. C.

10.1101/2025.05.02.651384 — pharmacology and toxicology — Posted on 2025-05-04

5317 Saddle Curvature Association of nsP1 Facilitates the Replication Complex Assembly of Chikungunya Virus in Cells

Miao, X.; Law, M. C. Y.; Kumar, J.; Chng, C. P.; Zeng, Y.; Tan, Y. B.; Wu, J.; Guo, X.; Huang, L.; Zhuang, Y.; Gao, W.; Huang, C.; Luo, D.; Zhao, W.

10.1101/2025.05.01.641776 — biophysics — Posted on 2025-05-04

5318 Enhancing Neural Synchrony with Endogenous-like 1/f Noise Stimulation

Ping, A.; Guan, L.; Gu, H.; Jiang, Z.; Deng, W.; Chen, H.; Zeng, K.; Li, X.

10.1101/2025.04.30.651370 — biophysics — Posted on 2025-05-04

5319 SarcAsM: AI-based multiscale analysis of sarcomere organization and contractility in cardiomyocytes

Haertter, D.; Hauke, L.; Driehorst, T.; Nishi, K.; Long, J.; Tiburcy, M.; Berecic, B.; Primessnig, A.; Bao, G.; Cyganek, L.; Schmidt, C. F.; Zimmermann, W. H.

10.1101/2025.04.29.650605 — bioinformatics — Posted on 2025-05-04

5320 Frequency-Dependent Neurostimulation in Whole Brain Network models

Otero, M.; Poo, E.; Torres, F.; Mendoza, C.; Lea-Carnall, C. A.; Weinstein, A.; Guevara, P.; Prado, P.; Cabral, J.; EL-DEREDY, W.

10.1101/2025.04.30.651283 — bioengineering — Posted on 2025-05-04

5321 Effects of Visual Deprivation on Gait Stability During Treadmill Walking: Insights from a Bipedal Model

Rahimi, N.; Amiri, M.; Kamankesh, A.; Shoja, O.; Zhang, L.; Ghassemi, F.; Towhidkhah, F.

10.1101/2025.04.29.651071 — bioengineering — Posted on 2025-05-04

5322 Second-order elasticities for Ecology and Evolution: Unravelling nonlinear fitness responses to perturbations

Kajin, M.; Tuljapurkar, S. D.; ZUO, W.; Jaggi, H.; Gascoigne, S.; Salguero-Gomez, R.

10.1101/2025.04.30.651456 — ecology — Posted on 2025-05-04

5323 Proteome-level robustness and the role of a histone-like protein during acute heat shock in the hyperthermophilic archaeon Pyrococcus furiosus

Okabe, H.; Miura, M. C.; Sato, A.; Adachi, S.; Kanai, A.

10.1101/2025.05.02.651969 — molecular biology — Posted on 2025-05-04

5324 Metagenomes and Metagenome-Assembled Genomes from Tidal Lagoons at a New York City Waterfront Park

Kong, S.; Abrams, E.; Binik, Y.; Cappelli, C.; Chu, M.; Cornett, T.; Culbertson, I.; Garcia, E.; Henry, J.; Lam, K.; Lampman, D.; Morenko, G.; Rivera, I.; Swift, T.; Torres, I.; Velez, R.; Waxman, E.; Wessely, S.; Yuen, A.; Lardner, C. K.; Weissman, J.

10.1101/2025.05.01.651762 — microbiology — Posted on 2025-05-04

5325 A Fundamental Approach to Buoyant Density Determination by DGE-AUC

Yarawsky, A. E.; Cardenas Lopez, P.; Walter, J.; DeLion, M. T.; Paul, L. N.

10.1101/2025.04.28.650698 — biophysics — Posted on 2025-05-04

5326 Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system

Azieh, A.; Hernandez, P. R.; Anderson, A. C.; Sychantha, D.; Verster, A. J.; Whitney, J.; Ross, B. D.

10.1101/2025.05.03.651265 — microbiology — Posted on 2025-05-04

5327 Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes

Medina, J. M.; Iruzubieta, P.; Fernandez-Lopez, R.; Crespo, J.; de la Cruz, F.

10.1101/2025.05.03.652020 — microbiology — Posted on 2025-05-04

5328 The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales

Cartagena, A. J.; Taylor, K. L.; Lopez, L. C.; Su, J.; Smith, J. T.; Manson, A. L.; Chen, J. D.; Pierce, V. M.; Earl, A. M.; Bhattacharyya, R. P.

10.1101/2023.05.23.541813 — microbiology — Posted on 2025-05-04

5329 Non-equilibrium strategies for ligand specificity in signaling networks

Goetz, A.; Barrios, J.; Madsen, R. R.; Dixit, P. D.

10.1101/2024.10.01.615884 — systems biology — Posted on 2025-05-04

5330 Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer's Disease spectrum

Mukherjee, S.; Coyle, R.; Dubois, C.; Perez, K.; Mclean, C.; Masters, C.; Roberts, B. R.

10.1101/2025.04.29.650793 — neuroscience — Posted on 2025-05-04

5331 Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis

Daunesse, M.; Sundaram, V.; Kentepozidou, E.; Connelly, J.; Anderson, C. J.; Liver Cancer Evolution Consortium, ; Lopez-Bigas, N.; Semple, C.; Odom, D. T.; Taylor, M. S.; Roller, M.; Aitken, S. J.; Flicek, P.

10.1101/2025.02.11.637769 — cancer biology — Posted on 2025-05-04

5332 Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging

Williamson, D. J.; Zaza, C.; Carlon Andres, I.; Gentili, A.; Daly, J. I.; Holmes, H.; Thrush, J.; Starling, T.; Neil, S.; Owens, R.; Malim, M. M.; Tynan, C.; Simoncelli, S.; Padilla-Parra, S.

10.1101/2025.04.11.648405 — biophysics — Posted on 2025-05-04

5333 multideconv - an integrative pipeline for combining first and second generation cell type deconvolution results

Hurtado, M.; Essabbar, A.; Khajavi, L.; Pancaldi, V.

10.1101/2025.04.29.651220 — bioinformatics — Posted on 2025-05-04

5334 Skeletal muscle-derived extracellular vesicles are altered with chronic contractile activity: a dynamic light scattering analysis

Obi, P. O.; Turner-Brannen, E.; West, A. R.; Labouta, H. I.; Gordon, J.; Saleem, A.

10.1101/2022.02.25.481852 — cell biology — Posted on 2025-05-04

5335 Disease-associated loci share properties with response eQTLs under common environmental exposures

Lin, W.; Li, M.; Allen, O.; Burnett, J.; Popp, J. M.; Stephens, M.; Battle, A.; Gilad, Y.

10.1101/2025.04.30.651602 — genetics — Posted on 2025-05-04

5336 Proteomic profiling of primary cilia in the developing brain uncovers newregulators of cortical development

Liu, X.; Torres Gutierrez, O.; Kaur, G.; Al-Issa, Y.; Baboo, S.; Diedrich, J. K.; Cai, E.; Yates, J. R.; Ge, X.

10.1101/2025.05.03.652041 — developmental biology — Posted on 2025-05-04

5337 Adaptations in common synaptic inputs to spinal motor neurons during grasping versus a less functional hand task

Cabral, H. V.; Cosentino, C.; Rizzardi, A.; Inglis, J. G.; Fuglevand, A. J.; Negro, F.

10.1101/2025.05.02.651931 — neuroscience — Posted on 2025-05-04

5338 Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

Schultz, C. W.; Saha, S.; Dhall, A.; Zhang, Y.; Desai, P.; Pongor, L. S.; Scheiblin, D. A.; Magidson, V.; Sun, Y.; Redon, C.; Kumar, S.; Krishnamurthy, M.; Dias, H. B.; Aksenova, V.; Giordano, E.; Takahashi, N.; Nirula, M.; Arora, M.; Tabe, C.; Thomas, M.; Kumar, R.; Arakawa, Y.; Jo, U.; Teicher, B. A.; Aladjem, M. I.; Lockett, S.; Dasso, M.; Pommier, Y.; Sharma, A. K.; Thomas, A.

10.1101/2025.04.29.651052 — cancer biology — Posted on 2025-05-03

5339 Computational design of conformation-biasing mutations to alter protein functions

Cavanaugh, P.; Xue, A.; Dai, S.; Qiang, A.; Matsui, T.; Ting, A. Y.

10.1101/2025.05.03.652001 — biophysics — Posted on 2025-05-03

5340 nanoFOLD : sequence design of nanobodies via inverse folding

Chomicz, D.; Janusz, B.; Wrobel, S.; Dudzic, P.; Polasa, A.; Martin, K.; Darnell, S.; Comeau, S. R.; Krawczyk, K.

10.1101/2025.04.29.651236 — bioinformatics — Posted on 2025-05-03

5341 13C tracing in synaptosomes reveals that SGLT2 inhibition with dapagliflozin prevents metabolic deficits in the 5X-FAD model of Alzheimer's Disease

Mekkittikul, M.; Zhu, C.; Danna, B. T.; Zuo, X.; Rios, A.; Yang, K.; Villanueva, M.; Agarwal, D.; Castro, D.; Gu, X.; Strofs, A. R.; Shirihai, O. S.; Stiles, L.; Frautschy, S. A.; Oscarsson, J.; Esterline, R. L.; Cole, G. M.; Divakaruni, A. S.

10.1101/2025.04.30.651373 — biochemistry — Posted on 2025-05-03

5342 Comparative phylogeography of lizards (Squamata: Phrynosomatidae) in Baja California and expansion of Callisaurus draconoides within the North American deserts

Gottscho, A. D.; Hollingsworth, B. D.; Espinal, J. L.; Leache, A. D.; Reeder, T. W.; de Queiroz, K.

10.1101/2025.04.29.650089 — evolutionary biology — Posted on 2025-05-03

5343 Natural variation in Caenorhabditis elegans collective behavior reveals potential adaptation to novel environments

Kang, Y. J.; Costa, A. C.; Ding, S. S.

10.1101/2025.04.29.651269 — evolutionary biology — Posted on 2025-05-03

5344 Deciphering the Population Ecology of Blossom Midge, Contarinia maculipennis Felt: An Emerging Threat to Tuberose Cultivation in India

Keerthi, M. C.; Firake, D. M.; Wagh, Y. S.; K, A.; Naga, K. C.; Prasad, K. V.; Pandit, S.

10.1101/2025.04.29.651280 — ecology — Posted on 2025-05-03

5345 Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

Long, J.; Ma, M.; Chen, Y.; Gong, B.; Zheng, Y.; Li, H.; Yang, J.

10.1101/2023.11.11.566697 — molecular biology — Posted on 2025-05-03

5346 Virion stripping: A new role for bacterial proteases

Rodriguez-Hernandez, C. J.; Terekhova, M.; Chen, P.; Perpich, J.; Potempa, B.; Carey, K. A.; Peeples, M. E.; Grayson, M. H.; Potempa, J.; Artyomov, M.; Lamont, R. J.; Bagaitkar, J.

10.1101/2025.05.03.652018 — microbiology — Posted on 2025-05-03

5347 A systematic approach to analyze T cell migration: application to mouse melanoma tumors

Memmos, N.; Mitchell, J. S.; Fife, B. T.; Masopust, D.; Odde, D. J.

10.1101/2025.04.29.651285 — immunology — Posted on 2025-05-03

5348 EpiMII: Integrating Structure and Graph Neural Networks for MHC-II Epitope and Neoantigen Design

Yuan, J.; Xu, X.; Sun, Z.-Y.; Liang, T.; Ge, J.; Jin, R.; Xie, X.-Q.; Chen, Y.; Hou, T.; Feng, Z.

10.1101/2025.04.29.651031 — immunology — Posted on 2025-05-03

5349 Aligned representation of visual and tactile motion directions in hMT+/V5 and fronto- parietal regions

Shahzad, I.; Battal, C.; Cerpelloni, F.; Van Audenhaege, A.; Mouraux, A.; Collignon, O.

10.1101/2025.03.24.645080 — neuroscience — Posted on 2025-05-03

5350 Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions

Klug, J. R.; Yan, X.; Hoffman, H.; Engelhardt, M. D.; Osakada, F.; Callaway, E.; Jin, X.

10.1101/2023.10.02.560589 — neuroscience — Posted on 2025-05-03

5351 Effects of stimulus modality and response type on oddball stimulus discrimination using polarity-considered EEG microstate labeling

Tsubaki, T.; Kashihara, S.; Asai, T.; Imamizu, H.; Nambu, I.

10.1101/2025.04.29.650929 — neuroscience — Posted on 2025-05-03

5352 Combined Angiographic, Structural and Perfusion Radial Imaging using Arterial Spin Labeling

Okell, T. W.; Woods, J. G.; Chiew, M.

10.1101/2025.04.29.651006 — neuroscience — Posted on 2025-05-03

5353 Minimal Gene Signatures Enable High-Accuracy Prediction of Antibiotic Resistance in Pseudomonas aeruginosa

Shahreen, N.; Shahid, S. A.; Subhani, M.; Alsiyabi, A.; Saha, R.

10.1101/2025.04.29.651273 — systems biology — Posted on 2025-05-03

5354 Improving RNA Secondary Structure Prediction Through ExpandedTraining Data

Langeberg, C. J.; Kim, T.; Nagle, R.; Meredith, C.; Garuadapuri, D. A.; Doudna, J. A.; Cate, J. H. D.

10.1101/2025.05.03.652028 — bioinformatics — Posted on 2025-05-03

5355 Enriching stabilizing mutations through automated analysis of molecular dynamics simulations using BoostMut

Korbeld, K. T.; Fürst, M. J. L. J.

10.1101/2025.04.29.651183 — bioinformatics — Posted on 2025-05-03

5356 Strain-level metagenomic profiling using pangenome graphs with PanTax

Luo, X.; Zhang, W.; Liu, Y.; Li, G.; Xu, J.; Chen, E.; Schonhuth, A.

10.1101/2025.04.29.651271 — bioinformatics — Posted on 2025-05-03

5357 Advancing Therapeutic Solutions: Poloxamer-based Thermosensitive Injectable Hydrogels containing a Self-assembling Peptide for In situ Gelation in an Osteoarthritis Murine Model

Sayedipour, S.; Schomann, T.; van de Looij, S. M.; Rezaie, S.; Ramos, Y. F. M.; Vermonden, T.; van der Weerd, L.; Meulenbelt, I.; Cruz, L. J.

10.1101/2025.04.30.651282 — biochemistry — Posted on 2025-05-03

5358 From Canopy Images to Organ-Level Disease Assessments: A Scalable Approach to Measure Quantitative Resistance in the Field

Zenkl, R.; McDonald, B. A.; Walter, A.; Unvericht, M.; Saintenac, C.; Anderegg, J.

10.1101/2025.04.30.651476 — biochemistry — Posted on 2025-05-03

5359 Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing System

Yu, B.; Li, P.; Xu, H.; Wang, Y.; Xu, K.; Hao, Y.

10.1101/2024.09.29.615652 — animal behavior and cognition — Posted on 2025-05-03

5360 Replication competition drives the selective mtDNA inheritance in Drosophila ovary

Zhang, C.; Chen, Z.; Ma, H.; Xu, H.

10.1101/2025.04.29.650984 — genetics — Posted on 2025-05-03

5361 Translation control of autophagy genes upon hydroxyurea-induced genotoxic stress

Mohanan, G.; Nag, K.; Senger, H. S.; Rajyaguru, P. I.

10.1101/2025.04.09.648074 — cell biology — Posted on 2025-05-03

5362 Open Educational Resources for distributed hands-on teaching in molecular biology

Cerda Rojas, A.; Aravena, A.; Arce, A.; Zapata, V.; Araya, W.; Gallardo, D.; Aviles, J.; Quero, F.; Nunez, I.; Matute, T.; Navarro, F.; Ferrando, V.; Blanco, M.; Velozo, S.; Aguilera, S.; Chateau, F.; Olivares, R.; Molloy, J. C.; Aidelberg, G.; Lindner, A. B.; Castro, F.; Cremades, P.; Ramirez-Sarmiento, C. A.; Federici, F.

10.1101/2024.03.28.587173 — molecular biology — Posted on 2025-05-03

5363 Mitochondrial translation termination, recycling, reinitiation, and rescue for in-frame and out-of-frame contexts

Wakigawa, T.; Mito, M.; Fang, Q.; Itoh, Y.; Shinkai, Y.; Iwasaki, S.

10.1101/2025.05.03.652009 — molecular biology — Posted on 2025-05-03

5364 Towards Unraveling Biomolecular Conformational Landscapes with a Generative Foundation Model

The OpenComplex Team, ; Ye, Q.

10.1101/2025.05.01.651643 — molecular biology — Posted on 2025-05-03

5365 Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes

Medina, J. M.; Iruzubieta, P.; Fernandez-Lopez, R.; Crespo, J.; de la Cruz, F.

10.1101/2025.05.03.652020 — microbiology — Posted on 2025-05-03

5366 Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system

Ross, B. D.; Whitney, J.; Verster, A. J.; Hernandez, P. R.; Azieh, A.; Anderson, A. C.; Sychantha, D.

10.1101/2025.05.03.651265 — microbiology — Posted on 2025-05-03

5367 Imbalance in gut microbial interactions as a marker of health and disease

Lopez, R. C.; Bonachela, J. A.; Dominguez-Bello, M. G.; Manhart, M.; Levin, S. A.; Blaser, M. J.; Munoz, M. A.

10.1101/2025.04.30.651474 — microbiology — Posted on 2025-05-03

5368 Preparation duration shapes the goal-directed tuning of stretch reflex responses

Rohlen, R.; Torell, F.; Dimitriou, M.

10.1101/2025.04.29.651111 — neuroscience — Posted on 2025-05-03

5369 Category-biased patches encircle core domain-general regions in the human lateral prefrontal cortex

Assem, M.; Shashidhara, S.; Glasser, M. F.; Duncan, J.

10.1101/2025.01.16.633461 — neuroscience — Posted on 2025-05-03

5370 Cross-order detection of bacteriophage transduction in communities using ribosomal RNA barcoding

LaTurner, Z. W.; Dysart, M. J.; Schwartz, S. K.; Zeng, E.; Chappell, J.; Silberg, J. J.; Stadler, L. B.

10.1101/2025.05.03.652062 — synthetic biology — Posted on 2025-05-03

5371 Growth rate-driven modelling reveals how phenotypic adaptation drives drug resistance in BRAFV600E-mutant melanoma

Hamis, S.; Browning, A. P.; Jenner, A. L.; Villa, C.; Maini, P. K.; Cassidy, T.

10.1101/2024.08.14.607616 — cancer biology — Posted on 2025-05-03

5372 multideconv - Integrative pipeline for cell type deconvolution from bulk RNAseq using first and second generation methods

Hurtado, M.; Essabbar, A.; Khajavi, L.; Pancaldi, V.

10.1101/2025.04.29.651220 — bioinformatics — Posted on 2025-05-03

5373 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction

Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.

10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-05-03

5374 Stretchable, hair-compatible, and long-term stable wearable EEG system

Hsieh, J.-C.; Yao, M.; Alawieh, H.; Koptelova, V.; Kumar, S.; Tang, K. K. W.; Wang, W.; Jeong, J.; Ding, H.; Chae, T.; Ahmad, Z.; Wang, D.; Engrav, T.; Wang, R.; Gupta, A.; He, W.; Moscoso-Barrera, W. D.; Grimes, A.; Millan, J. d. R.; Wang, H.

10.1101/2025.04.28.651043 — bioengineering — Posted on 2025-05-03

5375 Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

Sato, M.; Tanabu, D.; Torigoe, D.; Kadomatsu, T.; Taniwaka, K.; Ogata, Y.; Shiiba, I.; Suzuki, Y.; Inatome, R.; Tokuyama, T.; Takeiwa, T.; Inoue, S.; Kanai, E.; Hamano, T.; Hirata, H.; Kanamitsu, K.; Kusuhara, H.; Yokosuka, A.; Mimaki, Y.; Abe, H.; Oike, Y.; Yanagi, S.

10.1101/2025.05.01.651794 — biochemistry — Posted on 2025-05-03

5376 Chromosome scale genomes of two invasive Adelges species identifieshost immunity and developmental gene targets for selective pest control

Glendening, A. M.; Stephens, C.; Vuruputoor, V. S.; Stern, D. L.; Hogenhout, S. A.; Mathers, T. C.; Chaganti, T.; Pauloski, N.; Cernak, T. A.; Wegrzyn, J. L.; Fetter, K. C.

10.1101/2024.11.21.624573 — genomics — Posted on 2025-05-03

5377 Exposure to per- and polyfluoroalkyl substances elicits cell type-specific impacts on p53 and TGF-β signaling pathways

Ding, H.; Slack, M.; McClure, H.; Gu, W.; Nabinger, C.; Koviazina, R.; Gu, H.; Kappes, F.; Schultz, T.; Somarelli, J.; Tsigkou, A.

10.1101/2025.05.03.652004 — molecular biology — Posted on 2025-05-03

5378 Enteric infection priming confers IL-17A dependent protection from chemically-induced Colitis

Mishra, V.; Berkachy, R.; Biswas, P.; Frankel, G.

10.1101/2025.05.03.652030 — microbiology — Posted on 2025-05-03

5379 Genome-Wide Identification of Conditionally Essential Genes Supporting Streptococcus suis Growth in Serum and Cerebrospinal Fluid

Juanpere Borras, M.; Zhao, T.; Boekhorst, J.; Fernandez-Ciruelos, B.; Sanyal, R.; Arifa, N.; Wagenaar, T.; van Baarlen, P.; Wells, J.

10.1101/2025.05.03.652005 — microbiology — Posted on 2025-05-03

5380 Integrating simulated and experimental data to identify mitochondrial bioenergetic defects in Parkinson's Disease models

Chenna, S.; Joselin, A.; Bano, D.; Pizzo, P.; Ankarcrona, M.; Park, D. S.; Prehn, J. H.; Connolly, N. M. C.

10.1101/2025.04.29.651221 — neuroscience — Posted on 2025-05-03

5381 Electrophysiological recordings reveal photoreceptor coupling in the dorsal rim areas of honeybee and bumblebee eyes

Kolyfetis, G. E.; Belusic, G.; Foster, J. J.

10.1101/2025.04.29.651169 — neuroscience — Posted on 2025-05-03

5382 Phenotypic and Functional Characterization of Oncohistone Mutations in Breast Cancers

Edwards, A. D.; Dai, Y.; Singh, S.; Thornton, M.; Nandu, T.; Kittler, R.; Camacho, C. V.; Huang, D.; Kraus, W. L.

10.1101/2025.04.29.651098 — cancer biology — Posted on 2025-05-03

5383 NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

Xu, Y.; Nipper, M.; Dominguez, A.; He, C.; Sharkey, F.; Khan, S.; Xu, H.; Zhou, D.; Zheng, L.; Luan, Y.; Liu, J.; Wang, P.

10.1101/2025.04.29.651251 — cancer biology — Posted on 2025-05-03

5384 Lazypipe3: Customizable Virome Analysis Pipeline Enabling Fast and Sensitive Virus Discovery from NGS data

Weinstein, I.; Vapalahti, O.; Kant, R.; Smura, T.

10.1101/2025.04.29.651217 — bioinformatics — Posted on 2025-05-03

5385 AbBFN2: A flexible antibody foundation model based on Bayesian Flow Networks

Guloglu, B.; Braganca, M.; Graves, A.; Cameron, S.; Atkinson, T.; Copoiu, L.; Laterre, A.; Barrett, T. D.

10.1101/2025.04.29.651170 — bioinformatics — Posted on 2025-05-03

5386 Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal

Mitchell, J. T.; Stapleton, O.; Krishnan, K.; Nagaraj, S.; Lvovs, D.; Cherry, C.; Poissonnier, A.; Horton, W.; Adey, A.; Rao, V.; Huff, A.; Zimmerman, J. W.; Kagohara, L. T.; Zaidi, N.; Coussens, L. M.; Jaffee, E. M.; Elisseeff, J. H.; Fertig, E. J.

10.1101/2025.05.02.651747 — bioinformatics — Posted on 2025-05-03

5387 Fluid shear stress promotes glial-mediated neurotoxicity in vitro via purinergic signaling

Tenney, S.; Streilein, C.; Bermudez, A.; Keller, Z.; Cornelison, R. C.

10.1101/2025.04.29.651240 — bioengineering — Posted on 2025-05-03

5388 Rational Molecular Design of Two-Photon Activated Temoporfin: A Computational Study for Advanced Photodynamic Therapy

Koca-Findik, B.; Uyar, E. S.; MONARI, A.; Catak, S.

10.1101/2025.05.02.651861 — biochemistry — Posted on 2025-05-03

5389 Maternal PFAS Transfer through Lactation: Dolphin Milk Reveals Routes of Early-Life Exposure

Joseph, K. M.; Falls, A. T.; Dodds, J. N.; Power, M. L.; Baker, E. S.

10.1101/2025.05.02.651903 — biochemistry — Posted on 2025-05-03

5390 Structure-activity relationship of an all-α-helical prenyltransferase reveals a mechanism for indole prenylation.

Oshiro, T.; Uehara, S.; Tanaka, Y.; Ito, T.; Kodera, Y.; Matsui, T.

10.1101/2025.05.02.651859 — biochemistry — Posted on 2025-05-03

5391 Condensin Accelerates Long-Range Intra-Chromosomal Interactions

Zou, F.; Li, Y.; Foldes, T.; Pinholt, H. D.; Smith, C.; Mirny, L.; Bai, L.

10.1101/2025.05.02.651983 — molecular biology — Posted on 2025-05-03

5392 Distinct Acetate Utilization Strategies Differentiate Butyrate and Octanoate Producing Chain-Elongating Bacteria

Gois, I. M.; Bowers, C. M.; Kim, B.-C.; Flick, R.; Lawson, C. E.

10.1101/2025.05.02.651941 — microbiology — Posted on 2025-05-03

5393 Effects of a novel Paraburkholderia phage IPK on the phenanthrene degradation efficiency of the PAH-degrading strain Paraburkholderia caledonica Bk.

Nieto, E. E.; Ghanem, N.; Cammarata, R. V.; Borim-Correa, F.; Coppotelli, B. M.; Chatzinotas, A.

10.1101/2025.05.02.651996 — microbiology — Posted on 2025-05-03

5394 A transgenic mouse allows to capture the HLA-C*06:02 immunopeptidome in a model of psoriasis

Braun, A.; Mobbs, J. I.; Chung, S.; Tuomisto, J. E.; Li, C.; Scull, K. E.; Ayala, R.; Anand, S.; Ramarathinam, S.; Kern, J. S.; Fourie, A.; McKinnon, M.; Baker, D. G.; Rao, N.; Mifsud, N. A.; Illing, P. T.; Vivian, J. P.; Rossjohn, J.; Purcell, A. W.

10.1101/2025.05.01.651638 — immunology — Posted on 2025-05-03

5395 Isolation of Neural Stem Cells Using Platelet Derived Growth Factor C

Omairi, H. K.; Meode, M.; Sait, S.; heemskerk, K. M.; Black, S.; Chan, J. A.; Cairncross, J. G.

10.1101/2025.04.29.650770 — neuroscience — Posted on 2025-05-03

5396 Automatic Individual Cortical Parcellation for the Human Connectome Project

Yang, C.; Coalson, T. S.; Farahibozorg, S.-R.; Bijsterbosch, J. D.; Smith, S. M.; Van Essen, D. C.; Glasser, M. F.

10.1101/2025.04.29.651219 — neuroscience — Posted on 2025-05-03

5397 Inter-brain similarity and connectivity based on EEG hyperscanning during patient-acupuncturist interactions

Wang, G.

10.1101/2025.04.29.651215 — neuroscience — Posted on 2025-05-03

5398 Benchmarking Universal Machine Learning Force Fields with Hydrogen-Bonding Cooperativity

Feng, X.; Xu, Y.; Huang, J.

10.1101/2025.04.29.651212 — biophysics — Posted on 2025-05-03

5399 Pervasive phenotypic effects of Fbxo42 controlled by regulation of PP4 phosphatase

D'Angiolella, V.; Yang, H.; Smith, P.; Ma, Y.; Southworth, E.; Gopala-Krishna, V.; Salerno, B.; Rowland, J. M. S.; Grieco, D.; Kessler, B. M.; Fischer, R.

10.1101/2025.05.02.651838 — biochemistry — Posted on 2025-05-03

5400 Mutations in Hsp40 co-chaperone change the unique canonical inter-domain interactions stimulating LGMDD1 myopathy

Bhadra, A. K.; Aggarwal, G.; Jaysingh, M. A.; Chen, D.; Daw, J.; Weihl, C. C.; True, H.

10.1101/2025.05.02.651952 — biochemistry — Posted on 2025-05-03

5401 Tracing Siderophore Precursors to Primary Metabolism for Ecological Applications

He, R.; Xu, J.; Shao, J.; Wu, Y.; Wei, Z.; Gu, S.; Li, Z.

10.1101/2025.04.30.651379 — biochemistry — Posted on 2025-05-03

5402 Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae

de La Roche Saint-Andre, C.

10.1101/2025.04.29.651238 — genetics — Posted on 2025-05-03

5403 A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Mohammed, S.; Jiang, C.; Pennington, T.; Bhaskaran, S.; Ohene-Marfo, P.; Georgescu, C.; Pitts, K.; Tran, A.; Peng, Z.; Singh, A.; Yang, Z.; Li, T.; Hannafon, B.; Houchen, C.; Wren, J. D.; Galvan, V.; Ahsan, N.; Kinter, M.; Lewis, T. L.; Deepa, S. S.

10.1101/2025.05.02.651782 — cell biology — Posted on 2025-05-03

5404 Loss of circulating glucocorticoid rhythm disrupts the circadian transcriptome and vascular reactivity in the mouse renal artery

Krilis, G.; Costello, H. M.; Turner, F.; Little, R.; Komolova, A.; Nespoux, J.; Czopek, A.; Dunbar, D. R.; Bailey, M. A.; Ivy, J. R.

10.1101/2025.04.29.650449 — physiology — Posted on 2025-05-03

5405 Spatialproteomics - an interoperable toolbox for analyzing highly multiplexed fluorescence image data

Meyer-Bender, M. F.; Voehringer, H. S.; Schniederjohann, C.; Koziel, S. P.; Chung, E. K.; Popova, E.; Brobeil, A.; Held, L.-M.; Munir, A.; Scverse Community, ; Dietrich, S.; Bruch, P.-M.; Huber, W.

10.1101/2025.04.29.651202 — bioinformatics — Posted on 2025-05-03

5406 Deciphering Biosynthetic Gene Clusters with a Context-aware Protein Language Model

Kang, Z.; Zhang, H.; Liang, C.; Yang, R.; Ye, Y.; Bai, H.; Zhang, Y.; Ning, K.

10.1101/2025.04.29.651206 — bioinformatics — Posted on 2025-05-03

5407 Sedimentation and drag in drifting macrophytes and plastic objects: A model

Gronwald, F.; Weinberger, F.; Bouma, T. J.; Karez, R.

10.1101/2025.04.29.651208 — ecology — Posted on 2025-05-03

5408 A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4+ T cells in humans.

Kar, R.; Sinha, S.; Khatun, Z.; Sharma, A.; Patil, V. S.

10.1101/2025.04.29.651205 — immunology — Posted on 2025-05-03

5409 Expression and localization of NAGase and its effect on sperm motility in Duroc boars

lai, b.; lin, q.

10.1101/2025.04.29.651211 — zoology — Posted on 2025-05-03

5410 Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis

Ashford, A. L.; Nachmanson, D.; Wills, J. W.; Higgins, J. E.; Smith, T. H.; Vavra, K. C.; Dahalan, F.; Howe, J.; Elloway, J. M.; Salk, J. J.; Doherty, A.; Lynch, A. M.

10.1101/2025.04.29.651210 — pharmacology and toxicology — Posted on 2025-05-03

5411 AntiCP3: Prediction of Anticancer Proteins Using Evolutionary Information from Protein Language Models

Gupta, A.; Chauhan, M.; Tomer, R.; Raghava, G. P. S.

10.1101/2025.04.29.651196 — bioinformatics — Posted on 2025-05-03

5412 Weak and inverse latitudinal diversity gradients in the 10 most abundant and diverse flying insect clades

Santos, B. F.; Srivathsan, A.; Neves, K.; Meier, R.

10.1101/2025.04.29.651164 — ecology — Posted on 2025-05-03

5413 Multi-gene phylogeny and morphology of Pleurotus in Aotearoa New Zealand reveal a new variety of Pleurotus pulmonarius

Hera, D.; Cooper, J.; Buchanan, P. K.; Dhami, M. K.; Dickie, I. A.

10.1101/2025.04.29.651148 — ecology — Posted on 2025-05-03

5414 The Impact of Visual Perturbations on Balance Control during Walking

Li, Y.; Lambrecht, E.; Bruijn, S.; van Dieen, J. H.

10.1101/2025.04.29.651186 — neuroscience — Posted on 2025-05-03

5415 Glycerol Production and Diapause Are Most Likely Not Linked in Manduca sexta

Ades, R.

10.1101/2025.04.29.649890 — physiology — Posted on 2025-05-03

5416 A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia

Jones, L.; Rukhlenko, O. S.; Dias, T.; Imoto, H.; Carmody, C.; Wynne, K.; Kholodenko, B. N.; Bond, J.

10.1101/2025.04.29.651188 — cancer biology — Posted on 2025-05-03

5417 The impact of sex, age, and genetic ancestry on DNA methylation across tissues

Diez, W. O.; Ramirez, J. M.; Mele, M.

10.1101/2025.04.29.651179 — bioinformatics — Posted on 2025-05-03

5418 Preparation duration shapes the goal-directed tuning of stretch reflex responses

Rohlen, R.; Torell, F.; Dimitriou, M.

10.1101/2025.04.29.651111 — neuroscience — Posted on 2025-05-03

5419 Deep bidirectional interplay between sensory integration and latent rule discovery

Benjamin, L.; Morillon, B.; Wyart, V.

10.1101/2025.04.29.651167 — neuroscience — Posted on 2025-05-03

5420 Stochasticity contributes to explaining minority and majority MOMP during apoptosis

Geiger, J.; Kloetzer, F.; Pollak, N.; Fullstone, G.; Morrison (Rehm), M.

10.1101/2025.05.02.651813 — cell biology — Posted on 2025-05-03

5421 LRP10 promotes trafficking of progranulin and prosaposin to lysosomes

Filippini, F.; Devireddy, S.; Ferguson, S.

10.1101/2025.05.02.651888 — cell biology — Posted on 2025-05-03

5422 A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

Yang, W.; Mei, F.; Lin, W.; Lee, J. E.; Nie, S.; Bley, C. J.; Hoelz, A. J.; Cheng, X.

10.1101/2025.05.02.651912 — cell biology — Posted on 2025-05-03

5423 A Novel Multilayer Cultivation Strategy Improves Light Utilization and Fruit Quality in Plant Factories for Tomato Production

Furuta, H.; Qu, Y.; Ishizuka, D.; Kawabata, S.; Sano, T.; Yamori, W.

10.1101/2025.05.02.651818 — plant biology — Posted on 2025-05-03

5424 Analysis of leaf CO2 Assimilation, CO and CH4 Release Under Different Environmental Settings

Casanova, D.; Bruhn, D.; Mikkelsen, T.

10.1101/2025.04.30.651537 — plant biology — Posted on 2025-05-03

5425 Allocation of resources among multiple daughter cells

Wirshing, A. C. E.; Alonso Matilla, R.; Yan, M.; Khalid, S.; Colarusso, A. V.; Odde, D. J.; Lew, D. J.

10.1101/2025.05.02.651883 — cell biology — Posted on 2025-05-03

5426 Specialized high-capacity mitochondria fuel cell invasion

Kenny-Ganzert, I. W.; Basta, L. P.; Wang, L.; Chi, Q.; Su, C.; Morton, K.; Meyer, J.; Sherwood, D. R.

10.1101/2025.05.02.651978 — cell biology — Posted on 2025-05-03

5427 TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin

Liang, J.; Wang, Y.; Demmerle, J.; He, B. J.; Ricketts, C. J.; Linehan, W. M.; Zang, C.; Cai, D.

10.1101/2025.05.02.651992 — cell biology — Posted on 2025-05-03

5428 Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages

Ikegame, A.; Kondo, A.; Morinishi, T.; Yamaguchi, Y.; Okutani, Y.; Maegawa, C.; Tada, S.

10.1101/2025.05.02.651854 — cell biology — Posted on 2025-05-03

5429 Effect of plant tissue culture parameters on the ploidy level of Physalis grisea, Solanum lycopersicum, and Solanum prinophyllum regenerants

Van Eck, J.; Swartwood, K.; Green, Y.; Gentile, I.; Lippman, Z. B.

10.1101/2025.05.01.651681 — plant biology — Posted on 2025-05-03

5430 Genetic, epigenetic and metabolite variation in peripheral European Yew (Taxus baccata L.) populations at an unexplored part of the species natural distribution

Aravanopoulos, F. A.; Dalmaris, E.; Avramidou, E.; Sarrou, E.; Xanthopoulou, A.; Multari, S.; Martens, S.

10.1101/2025.04.30.651400 — plant biology — Posted on 2025-05-03

5431 Sustainable Edamame Production in an Artificial Light Plant Factory with Improved Yield and Quality

Takano, T.; Wakabayashi, Y.; Wada, S.; Sano, T.; Kawabata, S.; Yamori, W.

10.1101/2025.05.01.651627 — plant biology — Posted on 2025-05-03

5432 Heterologous expression of the cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase in Chlamydomonas reinhardtii causes increased cell size and biomass productivity in mixotrophic conditions

Bussola, M.; Perozeni, F.; Meloni, M.; Pivato, M.; Zaffagnini, M.; Ballottari, M.

10.1101/2025.05.02.651950 — plant biology — Posted on 2025-05-03

5433 How social and economic policies have affected the genome of mezcal agaves: the contrasting stories of Bacanora and Espadin

Klimova, A.; Gutierrez Rivera, J. N.; Aguirre-Planter, E.; Eguiarte, L. E.

10.1101/2025.04.30.651404 — plant biology — Posted on 2025-05-03

5434 Vernalization regulatory network identifies potential novel functions for ZCCT genes within HvVRN2

Montardit-Tarda, F.; Puyo, I.; Contreras-Moreira, B.; Karsai, I.; Borrill, P.; Casas, A. M.; Igartua, E.

10.1101/2025.04.29.651237 — plant biology — Posted on 2025-05-03

5435 Identification of immune response genes of cassava during early phases of cassava brown streak virus infection

Sheat, S.; Winter, S.; Lillenthal, J.; Pucker, B.

10.1101/2025.04.29.651173 — plant biology — Posted on 2025-05-03

5436 SNRK3.15 is a crucial component of the sulfur deprivation response in Arabidopsis thaliana

Apodiakou, A.; Heyneke, E.; Alseekh, S.; Pinsorn, P.; Metzger, S.; Kopriva, S.; Schulze, W.; Hoefgen, R.; Whitcomb, S. J.

10.1101/2025.04.29.651231 — plant biology — Posted on 2025-05-03

5437 Chiral monoterpene dynamics of shoots and roots of Norway spruce in response to drought

Daber, L. E.; Kreuzwieser, J.; Meischner, M.; Williams, J.; Werner, C.

10.1101/2025.05.02.651829 — plant biology — Posted on 2025-05-03

5438 Acclimation of carbon metabolism to a changing environment across a leaf rosette of Arabidopsis thaliana

Brodsky, V.; Kerscher, A.; Urban, M.; Naegele, T.

10.1101/2025.04.29.651223 — plant biology — Posted on 2025-05-03

5439 VERNALIZATION2 (VRN2) alters early tiller development in a facultative spring hexaploid bread wheat (Triticum aestivum)

Hirsz, D.; Taylor, H.; Lacey, I.; Gauley, A.; Dixon, L. E.

10.1101/2025.04.30.651433 — plant biology — Posted on 2025-05-03

5440 Recurrent Emergence of Boundary Cell Types During Evolution of Floral Bullseye Patterns

Oud, S.; Zurowski, M. M.; van der Jagt, P. L.; Yeo, M. T. S.; Walker, J. F.; Moyroud, E.; Vroomans, R. M. A.

10.1101/2025.05.03.651954 — systems biology — Posted on 2025-05-03

5441 A moss N-Acetyltransferase-MAPK protein controls 2D to 3D developmental transition via acetylation and phosphorylation changes

de Luxan Hernandez, C.; Ammitsoe, T. J.; Kanne, J. V.; Stanimirovic, S.; Roux, M.; Weeks, Z.; Schutzbier, M.; Dürnberger, G.; Roitinger, E.; Zhang, L.; Spadiut, O.; Ishikawa, M.; Hasebe, M.; Moody, L.; Dagdas, Y.; Rodriguez, E.; Petersen, M.

10.1101/2025.05.02.650421 — plant biology — Posted on 2025-05-03

5442 Modulation of the GT Family 47 clade B gene affects arabinan deposition in elaters of Marchantia polymorpha

Kang, H. S. F.; Lampugnani, E. R.; Tong, X.; Prabhakar, P. K.; Flores-Sandoval, E.; Hansen, J.; Jorgensen, B.; Bowman, J. L.; Urbanowicz, B. R.; Ebert, B.; Persson, S.

10.1101/2025.05.02.651808 — plant biology — Posted on 2025-05-03

5443 Multiple effectors trigger nonhost resistance in Solanum americanum against Pseudomonas syringae

Kim, J.; Vlkova-Zlebkova, M.; McCann, H.; Sohn, K. H.

10.1101/2025.05.01.651788 — plant biology — Posted on 2025-05-03

5444 A simple and reliable PCR-based method to differentiate between XX and XY sex genotypes in Cannabis sativa

Riera-Begue, A.; Toscani, M.; Malik, A.; Dowling, C. A.; Schilling, S.; Melzer, R.

10.1101/2025.05.02.651914 — plant biology — Posted on 2025-05-03

5445 Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo

Zheng, Y.; Lee, Y.-C.; Wang, Y.-T.; Chiang, P.-K.; Chang, S.-L.; Hsu, H.-J.; Hsu, L.-S.; Bach, E.; Tseng, C.-Y.

10.1101/2025.05.01.651651 — genetics — Posted on 2025-05-03

5446 Diabetes mellitus and tuberculosis comorbidity induce unique microbial gut dysbiosis and associated metabolome.

Jena, S.; Bhalla, N.; Chaudhary, S.; Sharma, N.; Jana, P.; Das, B.; Nanda, R. K.

10.1101/2025.03.09.642224 — microbiology — Posted on 2025-05-03

5447 Nucleosome placement and polymer mechanics explain genomic contacts on 100kbp scales

Corrette, J.; Li, J.; Shao, H.; Veerasubramanian, P. K.; Spakowitz, A.; Downing, T. L.; Allard, J.

10.1101/2024.09.24.614727 — biophysics — Posted on 2025-05-03

5448 Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

Sergounioti, A.; Alonaris, E.; Rigas, D.

10.1101/2025.04.27.650828 — cell biology — Posted on 2025-05-03

5449 The reticulocyte restriction: invasion ligand RBP1a of Plasmodium vivax targets human TfR1, prohibitin-2, and basigin

Molina-Franky, J.; Röth, D.; Ararat-Sarria, M.; Patarroyo, M. A.; Kalkum, M.

10.1101/2025.05.01.651667 — microbiology — Posted on 2025-05-03

5450 Spatially Periodic Computation in the Entorhinal-Hippocampal Circuit During Navigation

Zhang, B.; Guan, X.; Mobbs, D.; Liu, J.

10.1101/2022.01.29.478346 — neuroscience — Posted on 2025-05-03

5451 The MpCAFA gene encodes a ciliary protein required for spermatozoid motility in the liverwort Marchantia polymorpha

MORITA, M.; Yamato, K. T.

10.1101/2025.04.26.650577 — plant biology — Posted on 2025-05-03

5452 Osteocyte Nicotinic Acetylcholine Receptors Impact Bone Mechanoadaptation in a Sexually Dimorphic Manner

Mora-Antoinette, M.; Garcia-Ortiz, A.; Obaji, M.; Saffari, A. W.; Matthews, M. D.; Wasi, M.; Lewis, K. J.

10.1101/2023.10.01.556129 — physiology — Posted on 2025-05-03

5453 A highly resolved integrated transcriptomic atlas of human breast cancers

Chen, A. D.; Kroehling, L.; Ennis, C.; Denis, G. V.; Monti, S.

10.1101/2025.03.13.643025 — cancer biology — Posted on 2025-05-03

5454 Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival

Liu, X.; Cortes, E.; Ji, Y.; Zhao, K.; Ho, J.; Liu, Y. S.; Davicioni, E.; Feng, F. Y.; Alumkal, J. J.; Spratt, D. E.; Sweeney, C. J.; Yu, H.; Hu, Q.; Cheng, Z.; Zhang, D.; Chatta, G.; Nastiuk, K. L.; Goodrich, D. W.; Rycaj, K.; Jamroze, A.; Kirk, J. S.; Puzanov, I.; Liu, S.; Wang, J.; Tang, D. G.

10.1101/2025.04.27.650697 — cancer biology — Posted on 2025-05-03

5455 Complex three-dimensional rearing environments amplify compensatory plasticity following early blindness

Ramamurthy, D. L.; Englund, M.; Kovacs, T. J.; Dodson, H.; Krubitzer, L. A.

10.1101/2025.05.02.651847 — neuroscience — Posted on 2025-05-02

5456 When Meaning Matters Most: Rethinking Cloze Probability in N400 Research

Arkhipova, Y.; Lopopolo, A.; Vasishth, S.; Rabovsky, M.

10.1101/2025.04.29.651301 — neuroscience — Posted on 2025-05-02

5457 Sperrfy the brain: A data-driven realization of Sperry's Chemoaffinity theory in the neural connectome

Koike, J.; Yada, Y.; Hira, R.; Naoki, H.

10.1101/2025.04.30.651442 — neuroscience — Posted on 2025-05-02

5458 High-Throughput Assessment of Vocal Modulation Following Chemogenetic Inhibition in Songbirds

Song, C.; Fujibayashi, M.; Abe, K.

10.1101/2025.05.02.651591 — neuroscience — Posted on 2025-05-02

5459 Frontal Vulnerability vs. Temporal Resilience: Neuro-compensatory mechanisms underline differential language aging trajectories

Jain, P.; Akhter, A.; Banerjee, A.

10.1101/2025.04.29.651293 — neuroscience — Posted on 2025-05-02

5460 Non-visually-derived mental objects tax "visual" pointers

Yu, X.; Türk, U.; Dods, A.; Tian, X.; Lau, E.

10.1101/2025.05.02.651748 — neuroscience — Posted on 2025-05-02

5461 Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits

Kvastad, L.; Kollotzek, A.; Saghaleyni, R.; Chang, C.-F.; Cao, T.; Lappalainen, T.

10.1101/2025.05.02.651876 — genetics — Posted on 2025-05-02

5462 Mitochondrial structure despite nuclear panmixia: sex-specific dispersal dictates population structure in sperm whales

Brennan, R.; Talbot, L. W.; Martinez, A.; Garrison, L. P.; Engelhaupt, D.; Vollmer, N. L.; Rosel, P. E.

10.1101/2025.04.29.651281 — evolutionary biology — Posted on 2025-05-02

5463 Persistently increased expression of PKMzeta and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins

Han, J.; Grau-Perales, A.; Harris, R. M.; Kao, H.-y.; Pal, A.; Alarcon, J.-M.; Sacktor, T. C.; Martiniani, S.; Hofmann, H. A.; Fenton, A. A.

10.1101/2025.04.28.651143 — neuroscience — Posted on 2025-05-02

5464 Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes

Li, J.; Tanzillo, A.; Pizzirusso, G.; Caccavano, A. P.; Chittajallu, R.; Sohn, M.; Abebe, D.; Zhang, Y.; Pelkey, K.; Dale, R.; McBain, C. J.; Petros, T. J.

10.1101/2025.05.02.651761 — neuroscience — Posted on 2025-05-02

5465 Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture

Soetomo, S. A.; Sharp, M. F.; Crismani, W.

10.1101/2025.05.02.651448 — genetics — Posted on 2025-05-02

5466 Inferring resource competition in microbial communities from time series

Chen, X.; Crocker, K.; Kuehn, S.; Walczak, A. M.; Mora, T.

10.1101/2025.01.08.631910 — ecology — Posted on 2025-05-02

5467 Stenotrophomonas maltophilia exhibits defensive multicellularity in response to a Pseudomonas aeruginosa quorum sensing molecule

Katharios-Lanwermeyer, S.; Zarrella, T. M.; Godsil, M.; Severin, S.; Casiano, A. E.; Tai, C.-H.; Khare, A.

10.1101/2025.05.02.651457 — microbiology — Posted on 2025-05-02

5468 Modeling viral shedding and symptom outcomes in oseltamivir-treated experimental influenza infection

Fujita, Y.; Akao, M.; Tatematsu, D.; Iwami, S.; Nakamura, N.; Iwanami, S.

10.1101/2025.05.02.651873 — microbiology — Posted on 2025-05-02

5469 Action intentions result in the task-specific integration of object features

Lee, N.; Niemeier, M.

10.1101/2025.04.28.651066 — neuroscience — Posted on 2025-05-02

5470 Calpain cleaves the carboxyl terminus of TRPV1 and modulates receptor tachyphylaxis

Jiang, J.; Wang, X.; Yang, J.; Gao, S.; Xu, J.; Liu, J.; Wang, Y.; Liang, P.; Zhang, Y.

10.1101/2025.04.28.651151 — neuroscience — Posted on 2025-05-02

5471 Action intentions reactivate representations of task-relevant cognitive cues

Lee, N.; Guo, L. L.; Nestor, A.; Niemeier, M.

10.1101/2024.11.29.626095 — neuroscience — Posted on 2025-05-02

5472 Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP

Kirk, L. M.; Garcia, G. C.; Hanka, D. C.; Zatyko, K.; Bartol, T. M.; Sejnowski, T. J.; Harris, K. M.

10.1101/2025.04.29.651313 — neuroscience — Posted on 2025-05-02

5473 MILD TRAUMATIC BRAIN INJURY IMPAIRS EPISODIC MEMORY IN RATS

Nah, G.; Antonopoulos, M.; Hohmann, A. G.; Port, N.; Crystal, J. D.

10.1101/2025.04.28.651041 — neuroscience — Posted on 2025-05-02

5474 Cortical Latency Predicts Reading Fluency from Late Childhood to Early Adolescence

Wang, F.; Nguyen, Q. T. H.; Kaneshiro, B.; Norcia, A. M.; McCandliss, B.

10.1101/2025.02.27.640126 — neuroscience — Posted on 2025-05-02

5475 Modular Engineering of Thermo-Responsive Allosteric Proteins

Hoffmann, K. H.; Kroell, A.-S.; Motzkus, N. A.; Lemmen, N.; Happ, N.; Wolf, B.; von Bachmann, A.; Southern, N.; Vogd, F.; Aschenbrenner, S.; Niopek, D.; Mathony, J.

10.1101/2025.05.02.651844 — synthetic biology — Posted on 2025-05-02

5476 Early-life PBDE flame retardant exposures cause neurobehavioral alterations in fish that persist into adulthood and vary by sex and route of exposure

McNabb-Kelada, N.; Burke, T.; Jayaraman, S.; Mills, L.; De La Torre, A.; Francoeur, M.; Schraeder, H.; Nacci, D.; Clark, B. W.; Whitehead, A.

10.1101/2025.04.28.651140 — pharmacology and toxicology — Posted on 2025-05-02

5477 TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma

Asad, M.; Inocencio, J.; Mitrasinovic, S.; Aoki, M.; Crisman, C.; Lasala, P.; Eskandar, E.; Guha, C.; Zang, X.; Parney, I. F.; Himes, B. T.

10.1101/2025.04.24.648993 — cancer biology — Posted on 2025-05-02

5478 A telomere to telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps

Patel, H. R.; Alreja, K.; Reis, A. M.; Chang, J. K.; Chew, Z. A.; Jung, H.; Hammond, J. M.; Deveson, I. W.; Ruiz-Herrera, A.; Marin-Gual, L.; Holleley, C. E.; Zhang, X.; Lister, N. C.; Whiteley, S. L.; Xiong, L.; Dissanayake, D. S. B.; Waters, P. D.; Georges, A.

10.1101/2025.05.01.651798 — genomics — Posted on 2025-05-02

5479 Facultative Cheating and Hybrid Vigor Resolves Cooperator-Cheater Conflict in a Yeast Public Goods System.

Raj, N.; Saini, S.

10.1101/2025.04.28.651155 — evolutionary biology — Posted on 2025-05-02

5480 Towards Unraveling Biomolecular Conformational Landscapes with a Generative Foundation Model

The OpenComplex Team, ; Ye, Q.

10.1101/2025.05.01.651643 — molecular biology — Posted on 2025-05-02

5481 HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy

Rivault, A.; Bernut, A.; Ben-Neji, M.; Abrantes, M.; Jansen, M.; Huc-Brandt, S.; Besteiro, S.; Bordat, Y.; Audemard, N.; Mesleard-Roux, M.; Perrais, D.; Neyrolles, O.; Lugo-Villarino, G.; Verollet, C.; Espert, L.; BEAUMELLE, B.

10.1101/2025.05.02.651870 — microbiology — Posted on 2025-05-02

5482 Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

Banerjee, S.; Minshall, N.; Cook, A. D.; Macleod, O.; Webb, H.; Higgins, M. K.; Carrington, M.

10.1101/2025.05.02.651885 — microbiology — Posted on 2025-05-02

5483 Plant age and genotype explain variation in the microbiome of natural Lotus corniculatus populations

Reis, F.; Lutap, K.; Durka, W.; Jung, J. H.; Kemen, E.; Bossdorf, O.

10.1101/2025.05.02.651871 — microbiology — Posted on 2025-05-02

5484 Diabetes mellitus affects urinary tissue tropism of group B streptococci in a sex-dependent manner

John, P.; Gautam, B.; Kulkarni, R.; Rogers, K. A.

10.1101/2025.05.02.651940 — microbiology — Posted on 2025-05-02

5485 Geographic Variation and Host Genetics Shape the Human Skin Microbiome

Seong, H. J.; Quince, C.

10.1101/2025.05.01.651599 — microbiology — Posted on 2025-05-02

5486 Bacterial glycosphingolipids orchestrate colonization and immune modulation in neonatal host

Heo, K.; Jung, D.-J.; Yoo, J.-S.; Goh, B.; Kasper, D. L.; Oh, S. F.

10.1101/2025.05.02.651985 — microbiology — Posted on 2025-05-02

5487 Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning

Shlesinger, D.; Sadilek, V.; Minot, M.; Stamkopoulos, E.; Bikias, T.; Kuhn, R.; Agrafiotis, A.; Taft, J. M.; Yermanos, A.; Reddy, S. T.

10.1101/2025.05.01.651552 — immunology — Posted on 2025-05-02

5488 Instrumental Punishment Learning Enhances the Intrinsic Excitability of Basolateral Amygdala Neurons

Wise, E. T.; Jean-Richard-dit-Bressel, P.; Yau, J. O. Y.; Power, J. M.; McNally, G.

10.1101/2025.05.02.651812 — neuroscience — Posted on 2025-05-02

5489 Theory of interaction between untuned modulatory inputs and tuned sensory inputs

Nguyen, T.; Palmigiano, A.; Miller, K. D.

10.1101/2025.04.28.651100 — neuroscience — Posted on 2025-05-02

5490 Brain Network Analysis in Alzheimer's Disease and Mild Cognitive Impairment using High-Density Diffuse Optical Tomography

Butters, E.; Collins-Jones, L.; Mesquita, R. C.; Acharya, D.; McKiernan, E.; Laurell, A. A.; Low, A.; Srinivasan, S.; O'Brien, J. T.; Su, L.; Bale, G.

10.1101/2025.04.28.651132 — neuroscience — Posted on 2025-05-02

5491 Mitochondrial dysfunction in Machado Joseph disease: insights from a multi-model system

Simo, I.; Robinson, K. J.; Kam, J.; Kuriakose, A.; Paric, E.; Cheng, F.; Potapenko, A.; An, Y.; Lee, A.; Laird, A. S.

10.1101/2025.05.01.651800 — neuroscience — Posted on 2025-05-02

5492 The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae

Yen, P.-S.; Verkuijl, S. A.; Capriotti, P.; Del Corsano, G.; Hoermann, A.; Inghilterra, M. G.; Aramburu-Gonzalez, I.; Kahn, M. A.; Christophides, G. K.; Vlachou, D.; Windbichler, N.

10.1101/2025.05.02.651860 — synthetic biology — Posted on 2025-05-02

5493 PBDE flame retardant exposure causes neurobehavioral and transcriptional effects in first-generation but not second-generation offspring fish

McNabb-Kelada, N.; Burke, T.; Jayaraman, S.; Mills, L.; De La Torre, A.; Francoeur, M.; Schraeder, H.; Nacci, D.; Clark, B.; Whitehead, A.

10.1101/2025.04.28.651134 — pharmacology and toxicology — Posted on 2025-05-02

5494 Organoid Models Derived from Primary Tumors and Patient-Derive Xenograft Tumors Reflect Platinum Sensitivity of Ovarian Cancer Patients

Nikeghbal, P.; Zamanian, D.; Burke, D.; Steinkamp, M. P.

10.1101/2024.06.28.601283 — cancer biology — Posted on 2025-05-02

5495 Characterization of a potential antibiotic target site on the ribosome

Golstein, M.; Wang, Y.; Byju, S.; Mohanty, U.; Whitford, P. C.

10.1101/2025.05.02.651724 — biophysics — Posted on 2025-05-02

5496 MAVISp: A Modular Structure-Based Framework for Protein Variant Effects

Arnaudi, M.; Beltrame, L.; Degn, K.; Utichi, M.; Scrima, S.; Sanchez-Izquierdo Besora, P.; Krzesinska, K.; Maselli, F.; Dorcakova, T.; Safer, J.; Estad, A. H.; Meldgard, K.; Becker, P.; Sora, V.; Pettenella, A.; Vinhas, J.; Bauer, L.; Saridaki, P.; Melidi, A.; Favaro, L.; Kiachaki, E.; Oswal, A.; Breitenstein, J.; Fas, B. A.; Tedeschi, G.; Sackett, P. W.; Cava, C.; Rohlin, A.; Nilbert, M.; Iqbal, S.; Lambrughi, M.; Tiberti, M.; Papaleo, E.

10.1101/2022.10.22.513328 — bioinformatics — Posted on 2025-05-02

5497 Variable performance of widely used bisulfite sequencing methods and read mapping software for DNA methylation

Kerns, E. V.; Weber, J. N.

10.1101/2025.03.14.643302 — bioinformatics — Posted on 2025-05-02

5498 CRISPR-On-Beads: A Simple and Sensitive Approach for Bacterial DNA Detection

Ye, J.; Liu, L.; Peng, R.; Xu, F.; Men, Y.; Du, K.

10.1101/2025.05.02.651981 — bioengineering — Posted on 2025-05-02

5499 Structural basis of DNA recombination catalysis and regulation by phiC31 integrase

Sun, Y. E.; Aspinall, L. P.; Joseph, A. P.; Colloms, S. D.; Stark, M.; Spagnolo, L.

10.1101/2025.05.02.651858 — biochemistry — Posted on 2025-05-02

5500 Epithelial-Immune-Stromal Interactions Define Divergent Repair and Fibrosis Pathways After Acute Kidney Injury in Human Renal Transplants

Azim, S.; Rousselle, T.; Zubair, H.; Shetty, A. C.; Archer, K. J.; Marshall, J.; Rajabi, A.; Lara, C.; Mustofa, S.; Drachenberg, C.; Bromberg, J.; Menon, M.; Maluf, D. G.; Akalin, E.; Mas, V. R.

10.1101/2025.04.30.651080 — biochemistry — Posted on 2025-05-02

5501 Socially integrated female chimpanzees have lower offspring mortality

Feldblum, J. T.; Walker, K. K.; Stanton, M. A.; Lonsdorf, E. V.; Mjungu, D. C.; Murray, C. M.; Pusey, A. E.

10.1101/2025.04.29.651242 — animal behavior and cognition — Posted on 2025-05-02

5502 A Murine Database of Structural Variants Enables the Genetic Architecture of a Spontaneous Murine Lymphoma to be Characterized

Ren, W.; Fang, Z.; Dolzhenko, E.; Saunders, C. T.; Cheng, Z.; Popic, V.; Peltz, G.

10.1101/2025.01.09.632219 — genetics — Posted on 2025-05-02

5503 Common misspecification of the generation interval leads to reproduction number underestimation in phylodynamic inference

Park, Y.; Koelle, K.

10.1101/2025.04.28.649807 — evolutionary biology — Posted on 2025-05-02

5504 Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution

Ishida, T.; Mercoli, J. I.; Heck, A. M.; Phelps, I.; Varnum-Finney, B.; Dozono, S.; Nourigat-McKay, C.; Kraskouskas, K.; Wellington, R.; Waltner, O.; Jackson, D. L.; Delaney, C.; Rafii, S.; Bernstein, I. D.; Aldinger, K. A.; Trapnell, C.; Zhao, H. G.; Hadland, B.

10.1101/2023.06.01.543314 — developmental biology — Posted on 2025-05-02

5505 A purification-free nucleic acid amplification platform for diverse samples

Kapadia, J. B.; N'Diaye, K. D. S.; Daoud, J.; Perreault, J.

10.1101/2025.05.02.651961 — molecular biology — Posted on 2025-05-02

5506 The dung beetle microbiome complements host metabolism and nutrition

Jones, J. A.; Moczek, A. P.; Newton, I. L. G.

10.1101/2025.05.02.651921 — microbiology — Posted on 2025-05-02

5507 Auranofin Inhibits Hepatitis E Virus Replication Via Reactive Oxygen Species

Tiller, K.; Williams, S. T.; Wang, B.; Tian, D.; Meng, X.-J.; Weger-Lucarelli, J.

10.1101/2025.05.02.651833 — microbiology — Posted on 2025-05-02

5508 Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection

Joyce, L. R.; Akbari, M. S.; Nguyen, D. T.; Spencer, B. L.; McIver, K. S.; Horswill, A. R.; Doran, K. S.; Keogh, R. A.

10.1101/2025.05.02.651901 — microbiology — Posted on 2025-05-02

5509 Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus

Di Genova, C.; Warren, C. J.; Johnson, S.; Riccio, S.; Roper, K.; Thomas, S. S.; Schlachter, A.-L.; Jorge, D.; Ralh, K.; Hassan, J.; Billington, E.; Brown, I. H.; Slomka, M. J.; Banyard, A. C.; James, J.

10.1101/2025.05.02.651910 — microbiology — Posted on 2025-05-02

5510 Influence of carbon-to-nitrogen ratio on the denitrifying activities of a methanol-fed, marine recirculating denitrification reactor, and the evolution of the bacteria community during the operating process.

Lestin, L.; Villemur, R.

10.1101/2025.05.02.651252 — microbiology — Posted on 2025-05-02

5511 Computational modelling of toroidal membranes at division and fission sites

Graham, C. L.; Parrag, M.; Stansfeld, P. J.; Rodrigues, C. D. A.

10.1101/2025.05.02.651843 — microbiology — Posted on 2025-05-02

5512 Exploring C1 substrate cofeeding in Eubacterium limosum with AneVO, a low-cost anaerobic parallel bioreactor platform

Hoyt, K. O.; Zhou, G.; Gasparrini, W.; Sliter, P. J.; Hart, D. J.; Khalil, A. S.; Woolston, B. M.

10.1101/2025.05.02.651948 — microbiology — Posted on 2025-05-02

5513 Modeling epithelial and endothelial cell tropism for SARS-CoV-2 through restricted transgenic hACE2 expression in mice

Lameire, S.; Debeuf, N.; Deckers, J.; De Wolf, C.; Vanheerswynghels, M.; Toussaint, W.; De Vlieger, L.; Van Hoecke, L.; De Cae, S.; Schepens, B.; Vanhee, S.; Lambrecht, B. N.

10.1101/2025.05.01.651662 — immunology — Posted on 2025-05-02

5514 Lymph nodes link sex-biased immune aging to compromised antigen recognition

Menzel, L.; Zschummel, M.; O'Melia, M. J.; Zhou, H.; Lei, P.-J.; Liu, L.; Sen, D. R.; Munn, L. L.; Padera, T. P.

10.1101/2025.02.11.637693 — immunology — Posted on 2025-05-02

5515 A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Shafer-Skelton, A.; Brady, T. F.; Serences, J. T.

10.1101/2024.02.26.582184 — neuroscience — Posted on 2025-05-02

5516 Phasic and tonic pain serve distinct functions during adaptive behaviour

Tong, S.; Denison, T.; Hewitt, D.; Lee, S. W.; Seymour, B.

10.1101/2025.02.10.637253 — neuroscience — Posted on 2025-05-02

5517 Context-Dependent PSIICOS: A Novel Framework for Functional Connectivity Estimation Accounting for Task-Related Power Leakage

Kleeva, D.; Ossadtchi, A.

10.1101/2024.12.30.630771 — neuroscience — Posted on 2025-05-02

5518 Expression and Characterization of SARS-CoV-2 Spike Protein in Thermothelomyces heterothallica C1

Ophir, Y.; Wong, J.; Haddad, K. R.; Huuskonen, A.; Karmaker, A.; Gore, V.; Jung, S.; Oloumi, A.; Liu, Y.; Fu, J.; Zhang, L.; Huang, P.; Minami, S. A.; Garimella, S. S.; Thyagatur, A.; Zaini, P. A.; Vitikainen, M.; Tchelet, R.; Valbuena, N.; Fuerst, T.; Korkmaz, E.; Falo, L. D.; Balmert, S. C.; Mahendiratta, S.; Emalfarb, M.; Shah, P.; Siegel, J. B.; Dandekar, A. M.; Chen, X.; Lebrilla, C. B.; Faller, R.; Saloheimo, M.; McDonald, K. A.; Nandi, S.

10.1101/2025.05.01.651343 — bioengineering — Posted on 2025-05-02

5519 The structure of an ancient genotype-phenotype map shaped the functional evolution of a protein family

Herrera-Alvarez, S.; Patton, J. E. J.; Thornton, J. W.

10.1101/2025.01.28.635160 — evolutionary biology — Posted on 2025-05-02

5520 A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome

Harada, R.; Nishimura, Y.; Nomura, M.; Yabuki, A.; Shiba, K.; Inaba, K.; Inagaki, Y.; Nakayama, T.

10.1101/2025.05.02.651781 — evolutionary biology — Posted on 2025-05-02

5521 Molecular and Spatial Organization of the Primary Olfactory System and its Responses to Social Odors

Bintu, B.; Isogai, Y.; Zhuang, X.; Dulac, C.

10.1101/2025.05.02.651832 — neuroscience — Posted on 2025-05-02

5522 Escherichia coli with a 57-codon genetic code

Robertson, W. E.; Rehm, F. B. H.; Spinck, M.; Schumann, R. L.; Tian, R.; Liu, W.; Gu, Y.; Kleefeldt, A. A.; Day, C. F.; Liu, K. C.; Christova, Y.; Zurcher, J. F.; Boege, F. L.; Birnbaum, J.; van Bijsterveldt, L.; Chin, J. W.

10.1101/2025.05.02.651837 — synthetic biology — Posted on 2025-05-02

5523 Bounding phenotype transition probabilities via conditional complexity

Dingle, K.; Hagolani, P.; Zimm, R.; Umar, M.; O'Sullivan, S.; Louis, A.

10.1101/2024.12.18.629197 — biophysics — Posted on 2025-05-02

5524 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction

Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.

10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-05-02

5525 Chromatix: a differentiable, GPU-accelerated wave-optics library

Deb, D.; Both, G.-J.; Bezzam, E.; Kohli, A.; Yang, S.; Chaware, A.; Allier, C.; Cai, C.; Anderberg, G.; Eybposh, M. H.; Schneider, M. C.; Heintzmann, R.; Rivera-Sanchez, F. A.; Simmerer, C.; Meng, G.; Tormes-Vaquerano, J.; Han, S.; Shanmugavel, S. C.; Maruvada, T.; Yang, X.; Kim, Y.; Diederich, B.; Joo, C.; Waller, L.; Durr, N. J.; Pegard, N. C.; La Riviere, P. J.; Horstmeyer, R.; Chowdhury, S.; Turaga, S. C.

10.1101/2025.04.29.651152 — bioinformatics — Posted on 2025-05-02

5526 Evolutionary Sequence and Structural Basis for the Epistatic Origins of Drug Resistance in HIV

Biswas, A.; Choudhuri, I.; Huang, K.; Sun, Q.; Sali, A.; Echeverria, I.; Haldane, A.; Levy, R.; Lyumkis, D.

10.1101/2025.04.30.651576 — biophysics — Posted on 2025-05-02

5527 A high-throughput platform for biophysical antibody developability assessment to enable AI/ML model training

Arsiwala, A.; Bhatt, R.; Yang, Y.; Quintero Cadena, P.; Anderson, K.; Ao, X.; van Niekerk, L.; Rosenbaum, A.; Bhatt, A.; Smith, A.; Grippo, L.; Cao, X.; Cohen, R.; Patel, J.; Allen, O.; Faraj, A.; Nandy, A.; Hocking, J.; Tural, B.; Salvador, S.; Jacobowitz, J.; Schaven, K.; Sherman, M.; Shah, S.; Tessier, P. M.; Borhani, D.

10.1101/2025.05.01.651684 — biophysics — Posted on 2025-05-02

5528 S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: application to the study of human β-cardiac myosin

Barua, B.; Cail, R. C.; Goldman, Y. E.; Ostap, E. M.; Winkelmann, D. A.

10.1101/2025.05.01.651501 — biophysics — Posted on 2025-05-02

5529 Alpha-Synuclein Fibril Structures Cluster into Distinct Classes

Milchberg, M. H.; Warmuth, O. A.; Borcik, C. G.; Dhavale, D. D.; Wright, E. R.; Kotzbauer, P. T.; Rienstra, C. M.

10.1101/2025.04.30.651534 — biophysics — Posted on 2025-05-02

5530 DIRseq: a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

MacAinsh, M.; Qin, S.; Zhou, H.-X.

10.1101/2025.05.02.651562 — biophysics — Posted on 2025-05-02

5531 Segmental Isotope Labelling of the Prion Protein: Identification of a Key Residue for Copper-Mediated Interdomain Structure

Pavlovici, F. A.; Singewald, K.; Kaplan, S.; Chen, E.; Millhauser, G. L.

10.1101/2025.05.01.651769 — biophysics — Posted on 2025-05-02

5532 Light-guided molecular patterning for programmable multiplexed single-molecule manipulation

Choi, H.; Ward, A.; Wong, W. P.

10.1101/2025.04.30.651527 — biophysics — Posted on 2025-05-02

5533 H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves

Souza, C. K.; Santos, J. J. S.; Boggiatto, P.; Sterle, H.; Arruda, B.; Palmer, M. V.; Campos, A.; Liu, J.; Ye, N.; Weissman, D.; Hensley, S. E.; Baker, A. L.

10.1101/2025.05.01.651548 — microbiology — Posted on 2025-05-02

5534 Cuttlefish interaction with multimodal arm wave signs displays

Cohen Bodenes, S.; Neri, P.

10.1101/2025.04.13.648584 — animal behavior and cognition — Posted on 2025-05-02

5535 Quantifying the influence of genetic context on duplicated mammalian genes

Moffett, A. S.; Falcon-Cortes, A.; Di Pierro, M.

10.1101/2025.04.03.647042 — evolutionary biology — Posted on 2025-05-02

5536 Predation by a ciliate community mediates temperature and nutrient effects on a peatland prey prokaryotic community.

DeWitt, K.; Carrell, A.; Rocca, J.; Votzke, S.; Yammine, A.; Peralta, A. L.; Weston, D. J.; Pelletier, D. A.; Gibert, J. P.

10.1101/2024.04.05.588366 — ecology — Posted on 2025-05-02

5537 Scalable primordial germ cell-like-cell platform for functional genomics identifies epigenetic fertility modifiers

Li, L.; Gao, J.; Yi, D.; Sheft, A. P.; Schimenti, J. C.; Ding, X.

10.1101/2024.02.15.580543 — cell biology — Posted on 2025-05-02

5538 FakeRotLib: expedient non-canonical amino acid parameterization in Rosetta

Bell, E. W.; Brown, B. P.; Meiler, J.

10.1101/2025.02.27.640629 — bioinformatics — Posted on 2025-05-02

5539 Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

Jiang, H.; Druker, J.; Wilson, J. W.; Bensaddek, D.; Swedlow, J. R.; Rocha, S.; Lamond, A. I.

10.1101/2023.07.28.550951 — biochemistry — Posted on 2025-05-02

5540 Structurally distinct manganese-sensing riboswitch aptamers regulate different expression platform architectures

Stephen, C.; Palmer, D.; Bautista, C.; Mishanina, T.

10.1101/2024.12.14.628514 — biochemistry — Posted on 2025-05-02

5541 A stimulus-computable rational model of visual habituation in infants and adults

Raz, G.; Cao, A.; Saxe, R.; Frank, M. C.

10.1101/2024.08.21.609039 — animal behavior and cognition — Posted on 2025-05-02

5542 Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

Snyder, L. F.; O'Brien, E. M.; Zhao, J.; Liang, J.; Bruce, B. J.; Zhang, Y.; Zhu, W.; Cassier, T.; Schnicker, N. J.; Zhou, X.; Gordan, R.; He, B. Z.

10.1101/2024.04.20.590343 — evolutionary biology — Posted on 2025-05-02

5543 Tracing the Spread of Celtic Languages using Ancient Genomics

McColl, H.; Kroonen, G.; Pinotti, T.; Barrie, W.; Koch, J.; Ling, J.; Demoule, J.-P.; Kristiansen, K.; Sikora, M.; Willerslev, E.

10.1101/2025.02.28.640770 — evolutionary biology — Posted on 2025-05-02

5544 Competition for food affects the strength of reproductive interference and its consequences for species coexistence.

Cruz, M. A.; Godoy, O.; Fragata, I.; Sousa, V. C.; Magalhaes, S.; Zele, F.

10.1101/2023.11.09.566372 — ecology — Posted on 2025-05-02

5545 CD24 regulates the formation of ectosomes in B lymphocytes

Phan, H. D.; Squires, W. R. B.; Mayne, K. E.; Kelly, G. R.; Jafardoust, R.; Christian, S. L.

10.1101/2024.08.14.607772 — cell biology — Posted on 2025-05-02

5546 Single-cell multiomics identifies both shared and unique features of immune dysfunction in the colon, plasma and stool from individuals diagnosed with Parkinson's disease or inflammatory bowel disease

Bolen, M. L.; buendia, m.; Shi, J.; Staley, H.; Kachergus, J. M.; Efron, P. A.; Park, G.; Nagpal, R.; Xue, Q.-S.; McFarland, N. R.; Zimmermann, E. M.; Forsmark, C. E.; Menees, K. B.; Salas, A.; Thompson, E. A.; Tansey, M. G.

10.1101/2025.04.29.651228 — neuroscience — Posted on 2025-05-02

5547 The role of inhibitory neurons in novelty sound detection in regular and random statistical contexts.

Ding, X.; Vogler, N. W.; Tobin, M.; Garami, L.; Wood, K. C.; Geffen, M. N.

10.1101/2025.04.20.649735 — neuroscience — Posted on 2025-05-02

5548 Quantitative evaluation of normal cerebrospinal fluid flow in the Sylvian aqueduct and perivascular spaces of the middle cerebral artery and circle of Willis via 2D phase-contrast MR imaging

Le, R. F. D.; Karmonik, C.; Regnier-Golanov, A. S.; Golanov, E. V.; Britz, G. W.

10.1101/2025.02.11.637564 — neuroscience — Posted on 2025-05-02

5549 Functionality of potato virus Y coat protein in cell-to-cell movement is defined by flexibility of its N terminal region

Vozelj, A.; Povalej, T. M.; Stare, K.; Znidaric, M. T.; Bacnik, K.; Levak, V.; Aguirre, I. G.; Podobnik, M.; Gruden, K.; Coll, A.; Lukan, T.

10.1101/2025.04.29.651159 — plant biology — Posted on 2025-05-02

5550 Chemokinesis by a microbial predator

Quick, S. R.; Bains, J.; Gerdt, C.; Walker, B.; Goldstone, E. B.; Jakuszeit, T.; Baggaley, A. W.; Croze, O. A.; Gerdt, J. P.

10.1101/2025.05.01.651543 — biochemistry — Posted on 2025-05-02

5551 An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA

Palla, A. M.; Lin, C.-C.; Trnka, M. J.; Leao, E. M.; Petronikolou, N.; Burlingame, A. L.; McGinty, R. K.; Fujimori, D. G.

10.1101/2025.05.01.651538 — biochemistry — Posted on 2025-05-02

5552 Fmp30 is a phosphatidylinositol hydrolase that regulates CoQ biosynthesis

Baker, Z. N.; Guerra, R. M.; Rogers, S. W.; Pagliarini, D. J.

10.1101/2025.05.01.651778 — biochemistry — Posted on 2025-05-02

5553 Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry

Lee, A. S.; Fisher, N. P.; Marunde, M. R.; Su, P.; Khan, L. F.; Graham, B.; Taylor, H. F.; Onuoha, U. C.; Su, T.; Jooss, K.; Schachner, L. F.; Fuchs, H. A.; Noll, K.; Cheek, M. A.; Burg, J. M.; Sun, Z.-W.; Musselman, C. A.; Keogh, M. A.; Kelleher, N. L.

10.1101/2025.05.01.651740 — biochemistry — Posted on 2025-05-02

5554 Instant preparative droplet reaction assisted by shaking

Bi, M.; Zhao, L.; Tian, Z.

10.1101/2025.04.30.651440 — biochemistry — Posted on 2025-05-02

5555 Coordinated Discordance: Strategic Nest Attendance for Chick Rearing in Monogamous Seabird

Ochi, D.; Oka, N.; Watanuki, Y.

10.1101/2025.04.26.650791 — ecology — Posted on 2025-05-02

5556 Targeting Lysosomal Dysfunction to Alleviate Plaque Deposition in an Alzheimer Disease Model

Fremuth, L. E.; van de Vlekkert, D.; Hu, H.; Weesner, J. A.; Annunziata, I.; d'Azzo, A.

10.1101/2025.04.28.651121 — neuroscience — Posted on 2025-05-02

5557 Design of combination therapeutics from protein response to drugs in ovarian cancer cells

Franz, A.; Shen, C.; Coscia, F.; Munroe, K.; Charaoui, L.; Korkut, A.; Mann, M.; Luna, A.; Sander, C.

10.1101/2025.04.28.651139 — cancer biology — Posted on 2025-05-02

5558 Mapping of residues in leishmanial glyceraldehyde-3-phosphate dehydrogenase crucial for binding with 3'-UTR of TNF-alpha mRNA

Panja, P.; Das, S.; Dholey, Y.; Chowdhury, G.; Adak, S.

10.1101/2025.05.02.651801 — biochemistry — Posted on 2025-05-02

5559 Phosphite Production by Streptomyces viridochromogenes

Bailey, C. A.; Broening, E.; Greene, B. L.

10.1101/2025.05.01.651723 — biochemistry — Posted on 2025-05-02

5560 Genetic architecture and cellular basis of flag leaf size variation in barley

Lapasiya, T.; Gao, Y.; Wu, P.-Y.; Haweit, A.; van Inghelandt, D.; Stich, B.; Shrestha, A.

10.1101/2025.04.28.650967 — genetics — Posted on 2025-05-02

5561 Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

Ragusa, D.; Suen, C. W.; Torregrosa Cortes, G.; Pastorino, F.; Johns, A.; Ciciro, Y.; Dijkhuis, L.; van den Brink, S.; Cilli, M.; Byrne, C.; Ionescu, G.-A.; Cerveira, J.; Kranc, K. R.; Hernandez-Hernandez, V.; Ponzoni, M.; Bigas, A.; Garcia-Ojalvo, J.; Martinez Arias, A.; Pina, C.

10.1101/2022.10.07.511362 — developmental biology — Posted on 2025-05-02

5562 VEGF counteracts shear stress-determined arterial fate specification during capillary remodeling.

Chen, D.; Rukhlenko, O. S.; Joshi, D.; Rudnicki, M.; Coon, B. G.; Chakraborty, R.; Tuliakova, A.; Ioannou, E.; Martin, K. A.; Ruhrberg, C.; Kholodenko, B. N.; Schwartz, M. A.; Simons, M.

10.1101/2024.01.23.576920 — developmental biology — Posted on 2025-05-02

5563 Epitenon-derived cells comprise a distinct progenitor population that contributes to both fibrosis and regeneration following acute flexor tendon injury in a spatially-dependent manner

Nichols, A. E.; Benoodt, L.; Adjei-Sowah, E.; Jerreld, K.; Kollar, A.; Ketonis, C.; Loiselle, A. E.

10.1101/2023.01.30.526242 — cell biology — Posted on 2025-05-02

5564 Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila

Ramongolalaina, C.; Jia, Y.; Zhang, E.; Pastor-Pareja, J. C.

10.1101/2025.05.02.651826 — molecular biology — Posted on 2025-05-02

5565 All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex

Frisby, S. L.; Halai, A. D.; Cox, C. R.; Clarke, A.; Shimotake, A.; Kikuchi, T.; Kuneida, T.; Arakawa, Y.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Rogers, T. T.; Lambon Ralph, M. A.

10.1101/2025.04.17.649404 — neuroscience — Posted on 2025-05-02

5566 Replay builds an efficient cognitive map offline to avoid computation online

Ou, J.; Qu, Y.; Xu, Y.; Xiao, Z.; Behrens, T. E.; Liu, Y.

10.1101/2025.01.08.632067 — neuroscience — Posted on 2025-05-02

5567 Cancer-like fragmentomic characteristics of somatic variants in cell-free DNA

Zhang, Z.; An, Y.; Sun, K.

10.1101/2025.04.28.651130 — cancer biology — Posted on 2025-05-02

5568 NNMT is a biomarker of prostate cancer cells with a mesenchymal phenotype and induces sensitivity to metabolic agents

Carreira, A. S. A.; Ciuffreda, M.; Thongon, N.; Haughey, C. M.; Pickard, A.; Eddie, S. L.; Steele, R. E.; Cerri, E.; Belli, R.; Peroni, D.; Facen, E.; Caffa, I.; Ghanem, M.; Nencioni, A.; Lunardi, A.; Tebaldi, T.; Mills, I.; Provenzani, A.

10.1101/2025.04.29.651153 — cancer biology — Posted on 2025-05-02

5569 Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

Mallimadugula, U. L.; Cruz, M. A.; Vithani, N.; Zimmerman, M. I.; Bowman, G. R.

10.1101/2024.08.22.609218 — biophysics — Posted on 2025-05-02

5570 A Case-Based Explainable Graph Neural Network Framework for Mechanistic Drug Repositioning

Cavazos, A. C. G.; Tu, R.; Sinha, M.; Su, A. I.

10.1101/2025.04.28.651120 — bioinformatics — Posted on 2025-05-02

5571 Explainable deep learning for identifying cancer driver genes based on the Cancer Dependency Map

Yin, Q.; Chen, L.

10.1101/2025.04.28.651122 — bioinformatics — Posted on 2025-05-02

5572 Mitigation and detection of putative microbial contaminant reads from long-read metagenomic datasets

Ayala Montano, S.; Afolayan, A. O.; Kociurzynski, R.; Loeber, U.; Reuter, S.

10.1101/2024.11.26.625374 — bioinformatics — Posted on 2025-05-02

5573 Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta.

Gruner, H. N.; Pickett, C. J.; Bao, J. Y.; Garcia, R.; Hozumi, A.; Scully, T.; Ning, S.; Gao, M.; Bautista, G.; Maze, K.; Lim, K.; Osugi, T.; Collins-Doijode, M.; Cairns, O.; Levis, G.; Chen, S. Y.; Gong, T.; Satake, H.; Moshe-Klein, A.; Gigante, E. D.; Sasakura, Y.; Davidson, B.

10.1101/2025.04.28.651085 — developmental biology — Posted on 2025-05-02

5574 Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, OvMANE1: preclinical evaluation in mice model

Nebangwa, D. N.; Efeti, M. T.; Momnougui, S. M. E.; Shintouo, C. M.; Shey, R. A.; Ntie-Kang, F.; Ayiseh, R. B.; Ghogomu, S. M.

10.1101/2025.04.28.651093 — immunology — Posted on 2025-05-02

5575 MRI-Derived Markers of Acute and Chronic Inflammatory Processes in the VTA Associated with Depression

Khalife, S.; Bollmann, S.; Zalesky, A.; Oestreich, L. K. L.

10.1101/2025.04.30.651588 — neuroscience — Posted on 2025-05-02

5576 Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo

Zheng, Y.; Lee, Y.-C.; Wang, Y.-T.; Chiang, P.-K.; Chang, S.-L.; Hsu, H.-J.; Hsu, L.-S.; Bach, E.; Tseng, C.-Y.

10.1101/2025.05.01.651651 — genetics — Posted on 2025-05-02

5577 Mesenchymal WNT2B is Required for the Development and Function of the Human Intestine

Singh, A.; Poling, H. M.; Foulke-Abel, J.; Sundaram, N.; Al Reza, A.; Joseph, S.; Elseht, A.; Srivasta, K.; Krutko, M.; Mayhew, C. N.; Breault, D.; Wells, J. M.; Thiagarajah, J. R.; O'Connell, A. E.; Kovbasnjuk, O.; Helmrath, M. A.

10.1101/2025.05.01.651727 — developmental biology — Posted on 2025-05-02

5578 Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I

10.1101/2025.05.02.651799 — cell biology — Posted on 2025-05-02

5579 An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer

Xie, W.; Yu, X.; Yang, Q.; Ke, N.; Wang, P.; Kong, H.; Wu, X.; Ma, P.; Chen, L.; Yang, J.; Feng, X.; Wang, Y.; Shi, H.; Chen, L.; Liu, Y.-H.; Ding, B.-S.; Wei, Q.; Jiang, H.

10.1101/2024.11.19.624405 — immunology — Posted on 2025-05-02

5580 Targeted plasma proteomics uncover novel proteins associated with KIF5A-linked SPG10 and ALS spectrum disorders

Dulski, J.; Boddapati, A.; Risi, B.; Iruzubieta, P.; Orlacchio, A.; Fernandez Torron, R.; Castillo Trivino, T.; Lopez De M Arregui, A.; Vucic, S.; Kaat, L. D.; Barakat, T. S.; Petrucelli, L.; Prudencio, M.; Landers, J. E.; Prokop, A.; Weishaupt, J. H.; Filosto, M.; Wszolek, Z. K.; Pant, D. C.

10.1101/2025.04.29.651203 — neuroscience — Posted on 2025-05-02

5581 JNK activation dynamics drive distinct gene expression patterns over time mediated by mRNA stability

Jedariforoughi, A.; Burke, R.; Chesak, A.; Gonzalez-Hernandez, J. L.; Hanson, R. L.

10.1101/2025.05.02.651814 — systems biology — Posted on 2025-05-02

5582 The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation

D'Aloisio, L. D.; Ballal, M.; Ghosh, S.; Haskey, N.; Abulizi, N.; Karimianghadim, R.; Liu, C.; Sruthi, P.; Nagarajan, L.; Vasudevan, S.; Shetty, V.; Purandare, M.; Bhaumik, U.; Howlader, D. R.; Pakpour, S.; Barnett, J.; Gibson, D. L.

10.1101/2024.03.04.582285 — microbiology — Posted on 2025-05-02

5583 Gene Editing and Aging: A Bibliometric Analysis of Global Trends and Frontier Themes (2015-2024)

Chen, L.; Li, H.; Zhu, Y.; Zheng, Z.; Wang, J.; Wang, H.; Huang, W.; Luo, Y.

10.1101/2025.05.01.651618 — scientific communication and education — Posted on 2025-05-02

5584 Human life expectancies are still rising

Vinicius, L.; Migliano, A. B.

10.1101/2025.05.01.651310 — physiology — Posted on 2025-05-02

5585 Mechanistic basis for GPCR phosphorylation-dependent allosteric signaling specificity of β-arrestin 1 and 2

Madhu, M. K.; Murarka, R. K.

10.1101/2025.04.29.649777 — biophysics — Posted on 2025-05-02

5586 DNA Actively Regulates the "Safety-Belt" Dynamics of Condensin during Loop Extrusion

Chen, J.; Feng, C.; Wang, Y.; Chu, X.

10.1101/2025.04.29.651239 — biophysics — Posted on 2025-05-02

5587 Polymer dynamics reveal stage-wise unfolding and homologous pairing of chromosomes in S. pombe

Kumar, S.; Padinhateeri, R.; Thakur, S.

10.1101/2025.04.30.651601 — biophysics — Posted on 2025-05-02

5588 Functional and Structural Characterization of F1-ATPase with common ancestral core domains in stator ring

Suzuki, A. K.; Furukawa, R.; Sobti, M.; Brown, S. H. J.; Stewart, A. G.; Akanuma, S.; Ueno, H.; Noji, H.

10.1101/2025.04.30.651372 — biophysics — Posted on 2025-05-02

5589 Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation

Cho, Y.; Taniguchi, A.; Kubo, A.; Ikenouchi, J.

10.1101/2024.09.09.612007 — cell biology — Posted on 2025-05-02

5590 Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection

Lee, D.; Choi, S. Y.; Shin, S.-I.; An, H.; Choi, B.-S.; Park, J.

10.1101/2024.11.04.621999 — microbiology — Posted on 2025-05-02

5591 A functionally validated TCR-pMHC database for TCR specificity model development

10.1101/2025.04.28.651095 — immunology — Posted on 2025-05-02

5592 Regulation of B cell tolerance and autoimmunity by miR-130b

Herrero-Fernandez, B.; Gonzalez-Molina, M. d. P.; Gamez-Reche, L.; Prieto-Munoz, A. M.; Sanz, J.; Gonzalo, T.; Moreno, A.; Lopez-Molina, M.; Manas, L.; Nemazee, D.; Xiao, C.; Otero-Ortega, L.; Gonzalez-Martin, A.

10.1101/2025.01.22.634242 — immunology — Posted on 2025-05-02

5593 Self-Organizing Neural Networks in Organoids Reveal Principles of Forebrain Circuit Assembly

Hernandez, S.; Schweiger, H. E.; Cline, I.; Kaurala, G. A.; Robbins, A.; Solis, D.; Geng, J.; van der Molen, T.; Reyes, F.; Asogwa, C. N.; Voitiuk, K.; Chini, M.; Rolandi, M.; Salama, S. R.; Colquitt, B. M.; Sharf, T.; Haussler, D.; Teodorescu, M.; Mostajo-Radji, M. A.

10.1101/2025.05.01.651773 — neuroscience — Posted on 2025-05-02

5594 Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis.

Leavey, P.; Jiang, L.; Pannullo, N.; Santiago, C.; Blackshaw, S.

10.1101/2025.05.01.651492 — neuroscience — Posted on 2025-05-02

5595 Centroparietal signals track multiple rounds of evidence accumulation in an intermittent evidence task

Pares-Pujolras, E.; Geuzebroek, A. C.; O'Connell, R. G.; Kelly, S. P.

10.1101/2025.04.30.651428 — neuroscience — Posted on 2025-05-02

5596 An open, fully-processed data resource for studying mood and sleep variability in the developing brain

10.1101/2025.05.01.651544 — neuroscience — Posted on 2025-05-02

5597 Network Neuroscience of Human Multitasking: Local Features Matter

Mueckstein, M.; Hilger, K.; Heinzel, S.; Granacher, U.; Rapp, M. A.; Stelzel, C.

10.1101/2025.04.30.651494 — neuroscience — Posted on 2025-05-02

5598 Posterior parietal cortex mediates rarity-induced decision bias and learning under uncertainty

Sheng, W.; Huang, X.; Xie, Y.; Tsakiris, M. C.; Yang, Y.

10.1101/2024.10.25.620383 — neuroscience — Posted on 2025-05-02

5599 Dissection and internal anatomy of the giant tropical bont tick Amblyomma variegatum

Pature, N.; Pages, N.; Rodrigues, V.; MEYER, D. F.

10.1101/2025.02.13.636238 — zoology — Posted on 2025-05-02

5600 Testing the gearbox hypothesis for insect flight control

Ghosh, A.; Kumar G.S., G.; Sane, S. P.

10.1101/2025.04.29.651276 — zoology — Posted on 2025-05-02

5601 Is Britain still Great for Pine Marten? A Habitat Suitability Assessment

Lewis, E.; Swinnerton, K.; Fitzmaurice, A.; Armour-Chelu, N.; Gardner, R.; Ball, L.

10.1101/2025.03.19.643030 — zoology — Posted on 2025-05-02

5602 Insulin/insulin-like growth factor signaling pathway promotes higher fat storage in Drosophila females

Biswas, P.; Bako, J. A.; Liston, J. B.; Yu, H.; Wat, L. W.; Miller, C. J.; Gordon, M. D.; Huan, T.; Stanley, M.; Rideout, E. J.

10.1101/2024.11.18.623936 — physiology — Posted on 2025-05-02

5603 The Dual Nature of Body-Axis Formation in Hydra Regeneration: Polarity-Morphology Concurrency

Agam, O.; Braun, E.

10.1101/2025.04.29.651187 — biophysics — Posted on 2025-05-02

5604 Structural basis for no retinal binding in flotillin-associated rhodopsins

Kovalev, K.; Stetsenko, A.; Trunk, F.; Marin, E.; Haro-Moreno, J. M.; Lamm, G. H. U.; Alekseev, A.; Rodriguez-Valera, F.; Schneider, T. R.; Wachtveitl, J.; Guskov, A.

10.1101/2025.04.29.651185 — biophysics — Posted on 2025-05-02

5605 Reorganization of DNA loops by competition between condensin I and a linker histone

YAMAMOTO, T.; Shintomi, K.; Hirano, T.

10.1101/2025.04.29.651375 — biophysics — Posted on 2025-05-02

5606 Glycan Atlassing: Nanoscale analysis of glycocalyx architecture enables functional tracing of cell state

Joseph, D. M.; Yurekli, N.; Fritsche, S.; Hashem, R.; Thoma, O.-M.; Larafa, I.; Boric, T.; Bielawski, C.; Almahayni, K.; Franze, K.; Waldner, M. J.; Moeckl, L.

10.1101/2025.04.29.651200 — biophysics — Posted on 2025-05-02

5607 Recognizing amino acid sidechains in a medium resolution cryo-electron density map

Mondal, D.; Kumar, V.; Satler, T.; Ramachandran, R.; Saltzberg, D.; Chemmama, I.; Pilla, K. B.; Echeverria, I.; Webb, B. M.; Gupta, M.; Verba, K. A.; Sali, A.

10.1101/2024.12.10.627859 — biophysics — Posted on 2025-05-02

5608 Inflammasome Activation in Cutaneous Squamous Cell Carcinoma

Patel, K. R.; Shu, R. R.; Wang, R.; Tekale, K.; Hamersky, M.; Perez, A. B.; Solano, D.; Syed, N.; Stewart, C. E.; Lee, J.; Hanlon, A. M.; Blalock, T. W.; Li, C.; Seldin, L.

10.1101/2025.04.29.650608 — cell biology — Posted on 2025-05-02

5609 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in hepatocellular carcinoma

Xu, S.; Gong, R.; Liu, S.; Wang, J.; Shen, Y.; Peng, C.; Feng, Q.; Luo, M.; Lan, F.; Fan, J.; Cai, J.; Lan, X.

10.1101/2025.05.01.651793 — cell biology — Posted on 2025-05-02

5610 Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice

Asokaumar, A.; Mathur, B.; Chou, A.; Cronologia, B.; Alencastro, F.; Wheeler, L.; Mathews, C. K.; Moore, D. D.; Duncan, A. W.; Anakk, S.

10.1101/2025.04.29.651109 — cell biology — Posted on 2025-05-02

5611 Robust CENP-A incorporation in human cells is independent of transcription and cohesin components

Watanabe, R.; Perea-Resa, C.; Blower, M. D.

10.1101/2025.04.29.651290 — cell biology — Posted on 2025-05-02

5612 A genetic strategy to allow detection of F-actin by phalloidin staining in diverse fungi

Wirshing, A. C.; Colarusso, A. V.; Lew, D. J.

10.1101/2025.04.29.651289 — cell biology — Posted on 2025-05-02

5613 Temporal Dynamics of Azot Expression Following Traumatic Brain Injury.

Gutierrez-Garcia, A.; Marques-Reis, M.; Hauert, B.; Lampaya, E. M.

10.1101/2025.04.29.651334 — cell biology — Posted on 2025-05-02

5614 Conserved inter-domain interactions drive trans-Golgi network localisation and trafficking of homologous copper-ATPases

Jose, S. M.; Maji, S.; Paul, M.; Mallick Gupta, A.; Gupta, A.

10.1101/2025.05.01.651363 — cell biology — Posted on 2025-05-02

5615 Talin1 adhesions' morphology is largely unaffected by polyacrylamide substrate stiffness

Hajduk, J.; Twardawa, P.; Rajfur, Z.; Baster, Z.

10.1101/2025.04.30.651087 — cell biology — Posted on 2025-05-02

5616 MARK4 enhances stress granule formation and increases tau accumulation

Nakajima, S.; Sultanakhmetov, G.; Fukuchi, A.; Watanabe, K.; Ito, K.; Shimizu, S.; Asada, A.; Saito, T.; Ando, K.

10.1101/2025.04.30.651577 — cell biology — Posted on 2025-05-02

5617 Nonmuscle myosin 2 turnover in cells is synergistically controlled by the tail and the motor domain

Chougule, A.; Svitkina, T.

10.1101/2025.04.30.651508 — cell biology — Posted on 2025-05-02

5618 Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation

Juliani, J.; Tran, S.; Harris, T. J.; Ellis, S. L.; Al-Ani, A. H.; Patel, K. M.; Young, S. N.; Evangelista, M.; Baloyan, D.; Reehorst, C. M.; Nightingale, R.; Jenkins, L. J.; De Cruz, P.; Duszyc, K.; Kile, B. T.; Yap, A. S.; Mariadason, J. M.; Christensen, B.; Samson, A. L.; Murphy, J. M.; Fairlie, W. D.; Lee, E. F.

10.1101/2025.04.29.651340 — cell biology — Posted on 2025-05-02

5619 LHR and Gαs trafficking drive sustained cAMP signalling from endosomes to control steroidogenesis

Gourdon, J.; Haj-Hassan, M.; Jugnarain, V.; Gauthier, C.; Alves, S.; Guillou, F.; Reiter, E.; Jean-Alphonse, F.

10.1101/2025.04.30.651471 — cell biology — Posted on 2025-05-02

5620 Balanced DNA-to-Cytoplasm Ratio at the 2-Cell Stage Is Critical for Mouse Preimplantation Development

Ohsugi, M.; Pan, T.; Taira, N.

10.1101/2025.04.30.651589 — cell biology — Posted on 2025-05-02

5621 Engineering the C. elegans genome with a nested, self-excising selection cassette

Gibney, T. V.; Pani, A. M.

10.1101/2025.05.01.651742 — cell biology — Posted on 2025-05-01

5622 High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction

Thomas, V.; Mase, H.; Michon, L.; Picco, A.; Kaksonen, M.; Martin, S. G.

10.1101/2025.04.29.651207 — cell biology — Posted on 2025-05-01

5623 GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells

Deng, C.; Elujoba-Bridenstine, A.; Song, A. T.; Ceplina, R. M.; Ostheimer, C. J.; Hahn, M. C. P.; Scarlett, C. O.; Tamplin, O. J.

10.1101/2025.04.30.651482 — cell biology — Posted on 2025-05-02

5624 TMEM170 family proteins are lipid scramblases that physically associate with bridge lipid transporters BLTP1/Csf1

Rocha-Roa, C.; Sidhu, G.; Blair, P. C.; Alvarez, D.; Davey, M.; Conibear, E.; Vanni, S.

10.1101/2025.04.30.651444 — cell biology — Posted on 2025-05-02

5625 ATPγS unbiases kinesin

Karnawat, V.; Toleikis, A.; Molloy, J.; Carter, N.; Cross, R. A.

10.1101/2025.05.01.651652 — biophysics — Posted on 2025-05-01

5626 Cyclin A2 Induces Human Adult Cardiomyocyte Cytokinesis and Elicits Cardiomyocyte Reprogramming and Dedifferentiation

Bouhamida, E.; Vadakke-Madathil, S.; Mathiyalagan, P.; Ranjan, A.; Khan, A.; Sherman, C.; Miller, P. E.; Ghetti, A.; Abi-Gerges, N.; Chaudhry, H. W.

10.1101/2024.03.01.583057 — cell biology — Posted on 2025-05-01

5627 A Fully Defined Yeast iVT tRNA Translation Platform and the Synergistic Role of eIF5A and Mg2+

Jin, Y.

10.1101/2025.04.30.651424 — molecular biology — Posted on 2025-05-01

5628 Safety and Efficacy of a Novel Glycoengineered Recombinant Vaccine Candidate against Haemonchus contortus in Sheep

Sajovitz-Grohmann, F.; Adduci, I.; Werling, D.; Wiedermann, S.; Wortha, L. N.; Prole, B.; Zloebl, J.; Elster, J.; Tichy, A.; Joachim, A.; Wittek, T.; Hinney, B.; Yan, S.; Lichtmannsperger, K.

10.1101/2025.04.30.651318 — molecular biology — Posted on 2025-05-01

5629 Daily light exposure habits of youth with migraine: A prospective pilot study

Gentile, C. P.; Shah, R.; Marquez de Prado, B.; Raj, N.; Szperka, C. L.; Hershey, A. D.; Aguirre, G. K.

10.1101/2025.04.30.650986 — neuroscience — Posted on 2025-05-01

5630 Mechanical Artifacts During Transcranial Focused Ultrasound Mimic Biologically Evoked Responses

Nguyen, D. T.; Konofagou, E.; Dmochowski, J. P.

10.1101/2025.04.30.650712 — neuroscience — Posted on 2025-05-01

5631 Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort

Sim, M. A.; Rowsthorn, E.; O'Brien, W. T.; Sun, M.; Cribb, L.; Franks, K.; McDonald, S. J.; Yiallourou, S.; Cavuoto, M.; Harding, I. H.; Chong, T. T.-J.; Law, M.; O'Brien, T. J.; Vivash, L.; Pase, M.

10.1101/2025.04.30.651583 — neuroscience — Posted on 2025-05-01

5632 The China Brain Multi-omics Atlas Project (CBMAP)

Zhou, D.; Zhou, Y.; Sun, Z.; Ji, F.; Zhang, D.; Wang, Q.; Ruan, Y.; Wang, Y.; Zhu, Y.; Sun, X.; Li, M. J.; Yuan, C.; Liu, K.; Sun, L.; Zhai, W.; Fan, J.; Zhu, K.; Qiu, W.; Yan, X.; Ma, C.; Shen, Y.; Bao, A.; Yue, W.; Shi, Y.; Chen, C.; Yang, J.; Duan, S.; Zhang, J.

10.1101/2025.04.30.651445 — neuroscience — Posted on 2025-05-01

5633 Custom-Built Electrodes Perform Comparably to a Discontinued Commercial Electrode for Neuromuscular Electrical Stimulation in Mice

Odeh, B. H.; Wellman, A. L.; Ameye, M.; Atwood, Z.; Gray, L.; Saravanan, A.; Poluru, H.; Begam, M.; Jones, T. I.; Roche, R.; Roche, J. A.

10.1101/2025.04.30.651500 — physiology — Posted on 2025-05-01

5634 SynVerse: A Framework for Systematic Evaluation of Deep Learning Based Drug Synergy Prediction Models

TASNINA, N.; Haghani, M.; Murali, T. M.

10.1101/2025.04.30.651516 — pharmacology and toxicology — Posted on 2025-05-01

5635 Integrative multi-omics modelling for cultivated meat production, quality, and safety

Mathieu, T.; Legare, S.; Nzekoue, A. F.; Jaure, N.; Lester, H.; Dias, T.; Kusters, R.

10.1101/2025.04.30.651459 — bioinformatics — Posted on 2025-05-01

5636 Evaluation of epistasis detection methods for quantitative phenotypes

Listopad, S.; Peng, Q.; Renjith, G.

10.1101/2025.04.30.651312 — bioinformatics — Posted on 2025-05-01

5637 Does reduced reactivity explain altered postural control in Parkinson's disease? A predictive simulation study.

Shanbhag, J.; Fleischmann, S.; Wechsler, I.; Gassner, H.; Winkler, J.; Eskofier, B. M.; Koelewijn, A. D.; Wartzack, S.; Miehling, J.

10.1101/2025.04.30.651447 — bioengineering — Posted on 2025-05-01

5638 The phenotypic variation of widefins medaka is due to the insertion of a giant transposon containing a viral genome within hoxca cluster

Koita, R.; Otake, S.; Fukaya, N.; Yamamoto, K.; Maeno, A.; Kanno, H.; Matsuda, M.; Kawamura, A.

10.1101/2025.04.28.651082 — genetics — Posted on 2025-05-01

5639 Spatial patterns of diversity in forest birds of peninsular India

Goyal, N.; Sharma, A.; Jagati, V.; Herur, A.; Jain, A.; Gopal, A.; Joshi, J.; Robin, V. V.

10.1101/2025.04.28.650994 — ecology — Posted on 2025-05-01

5640 Gentrification influences mosquito community composition at neighborhood and county levels in Miami-Dade County, Florida

Scavo, N. A.; Vasquez, C.; Multini, L. C.; Mutebi, J.-P.; Wilke, A. B. B.

10.1101/2025.04.30.651397 — ecology — Posted on 2025-05-01

5641 A multipotent cell type from the term human placenta

Vadakke-Madathil, S.; Bouhamida, E.; Wang, B.; Mathiyalagan, P.; Ayyamperumal, P.; Khan, A.; Oniskey, M.; Santos-Gallego, C.; Hadley, M.; Croft, L.; Dekio, F.; Brody, R.; Gelber, S.; Sperling, R.; Chaudhry, H. W.

10.1101/2023.08.02.551028 — cell biology — Posted on 2025-05-01

5642 Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance

Culviner, P. H.; Frey, A. M.; Liu, Q. H.; Ha, D. T. M.; Thai, P. V. K.; Thu, D. D. A.; Quang, N. L.; Calderon, R.; Lecca, L.; Caws, M.; Dunstan, S. J.; Murray, M. B.; Thuong, N. T. T.; Fortune, S. M.

10.1101/2025.05.01.651750 — microbiology — Posted on 2025-05-01

5643 EEG Functional Connectivity as a Marker of Evolution from Infantile Epileptic Spasms Syndrome to Lennox-Gastaut Syndrome

Mila, B. R.; Liu, V. B.; Smith, R. J.; Hu, D. K.; Benneian, N. A.; Hussain, S. A.; Steenari, M.; Phillips, D.; Adams, D.; Skora, C.; Lopour, B. A.; Shrey, D. W.

10.1101/2025.04.30.650531 — neuroscience — Posted on 2025-05-01

5644 Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism

Brisset, M.; Radkova, K.; Paradisi, A.; Stephan, L.; Wagner, R.; Degletagne, C.; Luiggi, F.; Frydman, L.; Heriot, A.; Behrenbruch, C.; Vu, T.; Mehlen, P.; Hollande, F.

10.1101/2025.04.28.650943 — cancer biology — Posted on 2025-05-01

5645 Unmatched cell line collections are not optimal for identification of PARP inhibitor response and drug synergies

Phan, Z.; Fernandez, K. J.; Caldon, C. E.

10.1101/2025.04.28.650908 — cancer biology — Posted on 2025-05-01

5646 Development and evaluation of screwworm, Cochliomyia hominivorax, transgenic sexing strains with embryonic gene promoters for a genetic control program

Arp, A. P.; Lowman, A. V.; Concha, C.; Yan, Y.; Martinez, A.; Quintero, G.; Vasquez, M.; Sagel, A.; Scott, M. J.

10.1101/2025.05.01.651745 — biochemistry — Posted on 2025-05-01

5647 Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR

Guzman, B. B.; Goda, G. A.; Jimenez, A.; Martyr, J. G.; Hu, Y.; Cavazos, F. F.; Aleman, M. M.; Dominguez, D.

10.1101/2025.05.01.651718 — biochemistry — Posted on 2025-05-01

5648 Classification of outcomes in antimalarial therapeutic efficacy studies with Aster

Gerlovina, I.; Berube, S.; Briggs, J.; Murie, K.; Murphy, M.; Wesolowski, A.; Greenhouse, B.

10.1101/2025.04.28.651146 — genetics — Posted on 2025-05-01

5649 Species synonyms depict changing but taxon-independent taxonomic praxis

Iyer, V.; Prasad, A.

10.1101/2025.04.28.651127 — ecology — Posted on 2025-05-01

5650 Overcoming lentiviral delivery limitations in hard-to-transduce suspension cells for genome-wide CRISPR screening

Napoleone, A.; Sebastian, I. R.; De Marco, F.; Molin, A. K.; Hussein, M.; Kramer, L.; Jostock, T.; Kelly, T.; Borth, N.

10.1101/2025.05.01.651049 — molecular biology — Posted on 2025-05-01

5651 A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.

Zhang, H.; Audry, J.; Runge, K.

10.1101/2025.05.01.651670 — molecular biology — Posted on 2025-05-01

5652 Diversity and prevalence of Anaerostipes in the human gut microbiota

Bhattacharjee, D.; Millman, L. C.; Seesengood, M. L.; Seekatz, A. M.

10.1101/2025.05.01.651700 — microbiology — Posted on 2025-05-01

5653 The reticulocyte restriction: invasion ligand RBP1a of Plasmodium vivax targets human TfR1, prohibitin-2, and basigin

Molina-Franky, J.; Röth, D.; Ararat-Sarria, M.; Patarroyo, M. A.; Kalkum, M.

10.1101/2025.05.01.651667 — microbiology — Posted on 2025-05-01

5654 H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves

Souza, C. K.; Santos, J. J. S.; Boggiatto, P.; Sterle, H.; Arruda, B.; Palmer, M. V.; Campos, A.; Liu, J.; Ye, N.; Weissman, D.; Hensley, S. E.; Vincent Baker, A. L.

10.1101/2025.05.01.651548 — microbiology — Posted on 2025-05-01

5655 Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

Yabaji, S. M.; Zhernovkov, V.; Araveti, P. B.; Lata, S.; Rukhlenko, O. S.; Abdullatif, S. A.; Vanvalkenburg, A.; Alekseev, Y.; Ma, Q.; Dayama, G.; Lau, N. C.; Johnson, W. E.; Bishai, W. R.; Crossland, N. A.; Campbell, J. D.; Kholodenko, B. N.; Gimelbrant, A. A.; Kobzik, L.; Kramnik, I.

10.1101/2024.03.05.583602 — immunology — Posted on 2025-05-01

5656 Intratumoral amino acid insufficiency limits CD8+ T-cell effector function

Chen, Y.-T.; Lin, Y.-H.; Rahman, J.; Cross, J.; Pavlova, N. N.; Vardhana, S. A.

10.1101/2025.04.28.651077 — immunology — Posted on 2025-05-01

5657 A functionally validated TCR-pMHC database for TCR specificity model development

10.1101/2025.04.28.651095 — immunology — Posted on 2025-05-01

5658 Nanophysiology Approach Reveals Diversity in Calcium Microdomains across Zebrafish Retinal Bipolar Ribbon Synapses

Rameshkumar, N.; Shrestha, A. P.; Boff, J. M.; Hoon, M.; Matveev, V.; Zenisek, D.; Vaithianathan, T.

10.1101/2024.11.01.617078 — neuroscience — Posted on 2025-05-01

5659 It matters who you are: Biography modulates the neural dynamics of facial identity representation

Shi, Y.; Gommlich, S.; Kovacs, G.

10.1101/2025.04.08.647791 — neuroscience — Posted on 2025-05-01

5660 GenVS TBDB: An Open AI-Generated andVirtual Screened Small-Molecule Database for Tuberculosis Drug Discovery

Lv, X.; Guo, H.; Lu, X.; Tang, Z.; Yu, K.; Xu, G.; Chen, S.; Zhang, R.; Guo, J.

10.1101/2025.04.28.650819 — pharmacology and toxicology — Posted on 2025-05-01

5661 Low level of viral intra-host diversity is associated with severe SFTS disease

Wei, X.; Li, H.; Sai, L.; Song, L.; Gao, X.; Li, C.; Zhang, X.; Shen, Y.; Li, S.; Liu, L.; Golubchik, T.; Xu, Y.

10.1101/2025.04.28.650738 — pathology — Posted on 2025-05-01

5662 A deconvolution solution to aliasing confusion in apparently undersampled oblique plane microscopy

Lamb, J. R.; McFadden, C.; Fiolka, R.; Manton, J. D.

10.1101/2025.04.30.651458 — biophysics — Posted on 2025-05-01

5663 Non-Destructive Larval Genotyping of Danio rerio for Mitochondrial DNA Genetics

Mitra, K.; Holmberg, S. R.; Mota, M.; Sabharwal, A.; Ekker, S. C.

10.1101/2025.04.30.651585 — genetics — Posted on 2025-05-01

5664 Boundary-guided cell alignment drives mouse epiblast maturation

Ichikawa, T.; Guruciaga, P. C.; Hu, S.; Plunder, S.; Makino, M.; Hamaji, M.; Stokkermans, A.; Yoshida, S.; Erzberger, A.; Hiiragi, T.

10.1101/2025.04.28.650859 — developmental biology — Posted on 2025-05-01

5665 A kinetic ruler controls mRNA poly(A) tail length

Gabs, E.; Aalto-Setala, E.; Valisaari, A.; Malinen, A. M.; Heick Jensen, T.; McLaughlin, S. H.; Passmore, L. A.; Turtola, M.

10.1101/2025.05.01.651612 — molecular biology — Posted on 2025-05-01

5666 Exploring the diversity and physiological characteristics of RubisCO-mediated carbon fixation in culturable prokaryotes

Nishihara, A.; Kato, S.; Ohkuma, M.

10.1101/2025.05.01.651632 — microbiology — Posted on 2025-05-01

5667 Isolation and Characterization of Salt Tolerant Soil Bacteria from Selected Locations in the West Coast of Sri Lanka.

Senarath, N. G. L. C.; Edirisinghe, R.; Senarath-Yapa, M. D.; Hemachandra, I. P. A.; Somaratne, Y.; Jayawardana, N. U.

10.1101/2025.05.01.651645 — microbiology — Posted on 2025-05-01

5668 Efficient packaging of HIV-1 genomes via recognition of its adenosine-rich content by a heterologous RNA-binding domain

Vuong, H. R.; Zhou, Q.; Lesko, S.; Tenneti, K.; Davis, K.; Scott, S.; Boodwa-Ko, D.; Eschbach, J. E.; Gopal, K.; Porter, J.; Wang, Y.; Mohammed, S.; Lee, N.; Telesnitsky, A.; Sherer, N. M.; Kutluay, S. B.

10.1101/2025.05.01.651415 — microbiology — Posted on 2025-05-01

5669 Reprogramming the EnvZ-OmpR two-component system confers ethanol tolerance in Escherichia coli by stabilizing the outer membrane and altering iron homeostasis.

Schalck, T.; De Graeve, S.; Roba, L.; Baldoma, J. V.; Swings, T.; Van den Bergh, B.; Michiels, J.

10.1101/2025.05.01.651661 — microbiology — Posted on 2025-05-01

5670 Pathologic and phylogenetic characterization of Usutu virus infections in free-ranging wild birds in Switzerland (2015-2020)

Pisano, S. R. R.; Imlau, M.; Sattler, U.; Origgi, F. C.

10.1101/2025.05.01.651669 — microbiology — Posted on 2025-05-01

5671 Visualizing phenotypic heterogeneity and single-cell morphology in situ during gut infection

DiBenedetto, N. V.; Donnelly-Morell, M. L.; Kumamoto, C.; Shen, A.

10.1101/2025.04.30.651596 — microbiology — Posted on 2025-05-01

5672 Commercially Purchased and In-House Bred C57BL/6 Mice with Different Gut Microbiota Exhibit Distinct Indomethacin-Induced Toxicities

Zhang, J.; Thomas, V.; Sekela, J.; Zeller, M.; Sellers, R.; Redinbo, M.; Gulati, A.; Bhatt, A. P.

10.1101/2025.05.01.651704 — microbiology — Posted on 2025-05-01

5673 Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1

Guo, C.; Yu, Y.; Liu, J.; Jian, F.; Yang, S.; Song, W.; Shao, F.; Yu, L.; Cao, Y.

10.1101/2025.04.30.651462 — immunology — Posted on 2025-05-01

5674 Behaviors resulting from the activation of single olfactory receptor neuron class depends on multiple second-order neuron types

Wechsler, S. P.; Bhandawat, V.

10.1101/2025.05.01.651725 — neuroscience — Posted on 2025-05-01

5675 Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Weir, K.; Lyu, P.; Kandoi, S.; An, R.; Pannullo, N.; Palazzo, I.; Tangeman, J.; Shi, J.; DeVries, S.; Merriman, D.; Qian, J.; Blackshaw, S.

10.1101/2025.04.25.650540 — neuroscience — Posted on 2025-05-01

5676 Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers

Santander, T.; Bekir, S.; Paul, T.; Simonson, J. M.; Wiemer, V. M.; Skinner, H. E.; Hopf, J. L.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.

10.1101/2025.02.14.638327 — neuroscience — Posted on 2025-05-01

5677 MrHAMER2: high-accuracy long-read RNA sequencing to decode isoform-specific variation in viral transcripts during latency

Gallardo, C. M.; Albert, J. L.; Qazi, A. A.; Ventura, R. L.; Deshmukh, S.; Beliakova-Bethell, N.; Torbett, B. E.

10.1101/2024.12.19.629526 — genomics — Posted on 2025-05-01

5678 Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity

Soon, M. S.; Oyong, D. A.; Dooley, N.; Mukhiya, R.; Pava, Z.; Andrew, D.; Loughland, J. R.; McCarthy, J.; Chan, J.-A.; Beeson, J. G.; Engwerda, C.; Haque, A.; Boyle, M. J.

10.1101/2025.02.27.640479 — immunology — Posted on 2025-05-01

5679 Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant Calling

Hu, J.; Freed, D.; Feng, H.; Chen, H.; Li, Z.; Chen, H.

10.1101/2025.04.15.648987 — bioinformatics — Posted on 2025-05-01

5680 Contingency violation in extinction learning

Willma, R.; Peschken, J.; Pusch, R.; Rose, J.

10.1101/2025.04.28.651099 — animal behavior and cognition — Posted on 2025-05-01

5681 Ecology and environment predict spatially stratified risk of H5 highly pathogenic avian influenza clade 2.3.4.4b in wild birds across Europe

Hayes, S.; Hilton, J.; Mould-Quevodo, J.; Donnelly, C. A.; Baylis, M.; Brierley, L.

10.1101/2024.07.17.603912 — ecology — Posted on 2025-05-01

5682 Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

Wolfson, D.; Hull, J.; Li, Y.; Gonzalez, T.; Jayaram, M.; Devlin, G.; Cigliola, V.; Oonk, K.; Rosales, A.; Bursac, N.; Asokan, A.; Poss, K. D.

10.1101/2025.04.28.651096 — developmental biology — Posted on 2025-05-01

5683 Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue

Duarte Afonso Serdan, T.; Frank, B.; Cervantes, H.; Gargey, A.; Tian, Q.; Hope, D.; Choi, C. H. J.; Hoffmann, A.; Cohen, P.; Bluher, M.; Aydin, H.; Schwartz, G. J.; Shamsi, F.

10.1101/2024.09.24.613949 — cell biology — Posted on 2025-05-01

5684 A simple, inexpensive battery-powered homeothermic warming pad for mice and rats

Fleites, I. R.; Morales, K.; Roper, S. D.

10.1101/2025.04.28.651075 — neuroscience — Posted on 2025-05-01

5685 Mice dynamically adapt to opponents in competitive multi-player games

Erlich, J. C.; Rastogi, M.; Yin, Q.; Orsolic, I.; Cruz, B. F.; Almeida, A.; Duan, C. A.

10.1101/2025.02.14.638359 — neuroscience — Posted on 2025-05-01

5686 Regulatory logic of human cortex evolution by combinatorial perturbations

Skaros, A.; Vitriolo, A.; Leonardi, O.; Finazzi, V.; Pereira, M. F.; Prazzoli, F.; Trattaro, S.; Moriano, J.; Capocefalo, D.; Villa, C. E.; Boettcher, M.; Boeckx, C.; Testa, G.

10.1101/2025.04.28.651083 — systems biology — Posted on 2025-05-01

5687 PertEval-scFM: Benchmarking Single-Cell Foundation Models for Perturbation Effect Prediction

Wenteler, A.; Occhetta, M.; Branson, N.; Huebner, M.; Curean, V.; Dee, W.; Connell, W.; Hawkins-Hooker, A.; Chung, P.; Ektefaie, Y.; Valdez Cordova, C. M.; Gallagher-Syed, A.

10.1101/2024.10.02.616248 — bioinformatics — Posted on 2025-05-01

5688 GPFN: Prior-Data Fitted Networks for Genomic Prediction

Ubbens, J.; Stavness, I.; Sharpe, A. G.

10.1101/2023.09.20.558648 — bioinformatics — Posted on 2025-05-01

5689 From Pairwise Distances to Neighborhood Preservation: Benchmarking Dimensionality Reduction Algorithms for CyTOF, scRNA-seq, and CITE-seq

Bombina, P.; Adams, Z. B.; McGee, R. L.; Coombes, K. R.

10.1101/2025.04.28.651069 — bioinformatics — Posted on 2025-05-01

5690 iSHARC: Integrating scMultiome data for heterogeneity and regulatory analysis in cancer

Zeng, Y.; Bahl, S.; Xu, X.; Ci, X.; Keshavarzian, T.; Yang, L.; Lee, H. S.; Kossinna, P.; Gaiti, F.; Schwartz, G. W.; He, H. H.; Lupien, M.

10.1101/2025.04.28.651068 — bioinformatics — Posted on 2025-05-01

5691 OmiXAI: An Ensemble XAI Pipeline for Interpretable Deep Learning in Omics Data

Alaeva, A.; Lapteva, A.; Mikhaylovskaya, N.; Malkov, V.; Herbert, A.; Borevskiy, A.; Poptsova, M.

10.1101/2025.04.28.651097 — bioinformatics — Posted on 2025-05-01

5692 Subconcussive preconditioning prevents microglial morphology changes and improves cognitive outcomes in mice

Anderson, E. D.; Kim, K.; Georges, A. P.; Naveen, A.; Grajales, E.; Augustin, D. V.; Meaney, D. F.

10.1101/2025.04.28.651064 — bioengineering — Posted on 2025-05-01

5693 The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CODIGO): building local capacity in genomics, bioinformatics, and precision medicine

Marino-Ramirez, L.; Sharma, S.; Hamilton, J. M.; Nguyen, T. L.; Gupta, S.; Natarajan, A. V.; Nagar, S. D.; Menuey, J. L.; Chen, W.-A.; Sanchez-Gomez, A.; Satizabal-Soto, J. M.; Martinez, B.; Marrugo, J.; Medina-Rivas, M.; Gallo, J. E.; Jordan, I. K.; Valderrama-Aguirre, A.

10.1101/2025.04.28.651081 — genomics — Posted on 2025-05-01

5694 Tissue specific function of the Drosophila 7SK snRNP in controlling motoneuron synaptic growth

Mohana, G.; Kreim, N.; Roignant, J.-Y.

10.1101/2025.04.29.651232 — developmental biology — Posted on 2025-05-01

5695 Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers

Stephanou, A.; Mantri, M.; Shankaranarayanan, D.; Li, C.; Lagman, M.; Xiang, J. Z.; Pan, C.; Sun, Y.; Muthukumar, T.; Machaca, K.; de vlaminck, i.; Suthanthiran, M.

10.1101/2025.04.28.651042 — immunology — Posted on 2025-05-01

5696 Neural correlates of appetitive extinction learning: An fMRI study with actively participating pigeons

Sadraee, A.; Helluy, X.; Genc, E.; Gao, M.; Behroozi, M.; Guentuerkuen, O.

10.1101/2025.04.28.650993 — neuroscience — Posted on 2025-05-01

5697 Information-making processes in the speaker's brain drive human conversations forward

Goldstein, A.; Wang, H.; Sheffer, T.; Schain, M.; Zada, Z.; Niekerken, L.; Aubrey, B.; Nastase, S. A.; Gazula, H.; Casto, C.; Doyle, W. K.; Friedman, D.; Devore, S.; Dugan, P.; Hassidim, A.; Brenner, M.; Matias, Y.; Devinsky, O.; Flinker, A.; Hasson, U.

10.1101/2024.08.27.609946 — neuroscience — Posted on 2025-05-01

5698 Elucidation of the molecular interaction network underlying full-length FUS conformational transitions and its phase separation using atomistic simulations

Weng, S. L.; Mohanty, P.; Mittal, J.

10.1101/2025.04.28.651058 — biophysics — Posted on 2025-05-01

5699 MILD TRAUMATIC BRAIN INJURY IMPAIRS SPATIAL WORKING MEMORY IN RATS

Nah, G. D.; Hohmann, A. G.; Port, N.; Crystal, J. D.

10.1101/2025.04.28.650881 — animal behavior and cognition — Posted on 2025-05-01

5700 G protein-coupled receptor diversity and evolution in the closest living relatives of Metazoa

Garcia De Las Bayonas, A.; King, N.

10.1101/2025.04.15.649019 — evolutionary biology — Posted on 2025-05-01

5701 Integrin-TGFb axis induces partial EMT in basal-like cells to lead collective invasion

El-Gammal, A.; Jansen, L.; Verhagen, M. P.; Kremer, H.; Soufi, S.; Masoudnia, M.; Da Silva, I.; Westland, D.; Bult, P.; Fodde, R.; Verstegen, M. M. A.; Gloerich, M.; van Mil, S. W. C.; Khalil, A. A.

10.1101/2025.04.04.647177 — cell biology — Posted on 2025-05-01

5702 Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

Lee, S.; Ren, L.; Li, W.; Paranjpe, A.; Zhou, P.; Potter, A.; Huppert, S. S.; Shin, S.

10.1101/2024.04.13.589277 — cell biology — Posted on 2025-05-01

5703 Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene

Wells, A. T.; Bossardi Ramos, R.; Shen, M. M.; Binrouf, R. H.; D'Amico, A. E.; Lennartz, M. R.

10.1101/2024.12.09.627650 — immunology — Posted on 2025-05-01

5704 Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

Tran, T. P.; Budnik, B.; Froberg, J. E.; Macklis, J. D.

10.1101/2024.12.22.629968 — neuroscience — Posted on 2025-05-01

5705 A Novel Model for Proton Transport Mediated by Uncoupling Protein 1

Jacobsen, L.; Menon, S.; Gaudry, M. J.; Hakami Zanjani, A. A.; Reinholdt, P.; Jastroch, M.; Khandelia, H.

10.1101/2025.04.28.650983 — biophysics — Posted on 2025-05-01

5706 ScIsoX: A Multidimensional Framework for Measuring Transcriptomic Complexity in Single-Cell Long-Read Sequencing Data

Wu, S.; Schmitz, U.

10.1101/2025.04.28.650897 — bioinformatics — Posted on 2025-05-01

5707 Precision Through Frequency-Aware Prioritization: Introducing the Bouziane Similarity Index (BSI) for Rare Variants.

BOUZIANE, I.; LOUAFI, K.; LOUAFI, O.; ALLOUCHE, M.; SEKIOU, O.; BOUMENDJEL, M.

10.1101/2025.04.28.651048 — bioinformatics — Posted on 2025-05-01

5708 EXPRESSION GRAPH NETWORK FRAMEWORK FOR BIOMARKERDISCOVERY

Liu, Y.; Kannan, K.; Huse, J. T.

10.1101/2025.04.28.651033 — bioinformatics — Posted on 2025-05-01

5709 Regioselective Rapid Ene-type Reaction (RRER) Enables Bioconjugation of Histone Serotonylation

Wu, J.; Li, H.; Lovato, A.; Symasek, A.; Zheng, Q.

10.1101/2025.04.22.650073 — biochemistry — Posted on 2025-05-01

5710 Joint Modeling of Effect Sizes for Two Correlated Traits: Characterizing Trait Properties to Enhance Polygenic Risk Prediction

zhang, c.; Zhou, G.; Chen, T.; Zhao, H.

10.1101/2025.04.28.650892 — genetics — Posted on 2025-05-01

5711 The dynamics of coexistence and succession in a decaying ecosystem

Kalirad, A.; Theam, P.; Sommer, R. J.

10.1101/2025.04.28.650976 — ecology — Posted on 2025-05-01

5712 B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response

Xin, X.; Demircik, F.; Antipova, M.; Stylianakis, E.; Klein, M.; Bejarano, D. A.; Elwy, A.; Ebering, A.; Blanfeld, M.; Carter, K.; Johann, L.; Uhlfelder, D.; Blickberndt, E.; Probst, H. C.; Hoevelmeyer, N.; Bopp, T.; Arens, R.; den Haan, J. M.; Gommerman, J.; von Stebut, E.; Clausen, B.; Schlitzer, A.; Lang, K. S.; Becker, R. A.; Lemmermann, N.; Waisman, A.

10.1101/2025.04.28.651045 — immunology — Posted on 2025-05-01

5713 Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling

Tetenborg, S.; Shihabeddin, E.; Kumar, E. O. A. M.; Sigulinsky, C.; Dedek, K.; Lin, Y.-P.; Echeverry, F.; Hoff, H.; Pereda, A.; Jones, B. W.; Ribelayga, C.; Ebnet, K.; Matsuura, K.; O'Brien, J.

10.1101/2024.11.26.625481 — neuroscience — Posted on 2025-05-01

5714 HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

Wang, L.; Xing, p.; Zhao, X.; Song, X.; Wei, M.; Lei, L.; Xu, R.; Wang, R.; Ma, L.; You, D.; Chen, P.; Xie, M.; Zhao, M.; Zhang, H.; Lv, H.; Li, A.; Wang, X.; Gao, S.; Chen, X.

10.1101/2024.03.02.583089 — cancer biology — Posted on 2025-05-01

5715 Transient Formation of Supramolecular Complexes Between Hyaluronan and Oligopeptides at Submicromolar Concentration

Riopedre-Fernandez, M.; Chu, B.; Kuffel, A.; Marchioro, A.; Biriukov, D.; Martinez-Seara, H.

10.1101/2025.04.28.651036 — biophysics — Posted on 2025-05-01

5716 LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data

Abdi, H.; Ambaw, Y.; Chitraju, C.; Singh, S.; Zon, W. L.; Farese, R.; Walther, T. C.

10.1101/2025.04.28.650893 — bioinformatics — Posted on 2025-05-01

5717 Cellpose-SAM: superhuman generalization for cellular segmentation

Pachitariu, M.; Rariden, M.; Stringer, C.

10.1101/2025.04.28.651001 — bioinformatics — Posted on 2025-05-01

5718 Surface morphometrics reveals local membrane thickness variation in organellar subcompartments

Medina, M.; Chang, Y.-T.; Rahmani, H.; Fuentes, D.; Barad, B. A.; Grotjahn, D.

10.1101/2025.04.30.651574 — biochemistry — Posted on 2025-05-01

5719 Shoal cohesion and polarisation increase in turbid water and improve foraging performance

Ioannou, C. C.; Cordery, J.; Rands, S. A.

10.1101/2025.04.28.650972 — animal behavior and cognition — Posted on 2025-05-01

5720 Genomic-Thermodynamic Phase Synchronization: Maxwell's Demon-Like Regulation of Cell Fate Transition

Tsuchiya, M.; Yoshikawa, K.; Giuliani, A.

10.1101/2024.12.26.630379 — genomics — Posted on 2025-05-01

5721 A molecular circuit regulates fate plasticity in emerging and adult AT2 cells

Sawhney, A. S.; Deskin, B. J.; Cai, J.; Gibbard, D.; Ali, G.; Utoft, A.; Olson, A.; Hausman, H.; Sabol, L.; Holmberg, S.; Shah, R.; Warren, R.; De Langhe, S. P. J.; Benedito, R.; Inde, Z.; Sarosiek, K.; Lemire, E.; Haber, A. L.; Wang, L.; Wei, Z.; Brownfield, D. G.

10.1101/2025.04.28.650846 — developmental biology — Posted on 2025-05-01

5722 Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

Klein, R.; Onyuru, J.; Centa, J. L.; Viera, E. M.; Duelli, F. J.; Putnam, C. D.; Hoffman, H. M.; Hastings, M. L.

10.1101/2024.09.06.611206 — molecular biology — Posted on 2025-05-01

5723 Interaction between Model-based and Model-free Mechanisms in Motor Learning

Kumar, A. D.; Kumar, A.; Kumar, N.

10.1101/2025.04.28.651014 — neuroscience — Posted on 2025-05-01

5724 Changing cognitive chimera states in human brain networks with age: Variations in cognitive integration and segregation

Patton, A.; Davidsen, J.

10.1101/2025.04.28.650949 — neuroscience — Posted on 2025-05-01

5725 Repeated blood-brain barrier opening using low-intensity pulsed ultrasound mitigates amyloid pathology

Canney, M.; Bouchoux, G.; Carpentier, A.; De Rossi, P.

10.1101/2025.04.28.650998 — neuroscience — Posted on 2025-05-01

5726 Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis

Maitland, A. D.; Gonzalez, N. R.; Walther, D.; Pereira, F.; Baumann, M. H.; Glatfelter, G. C.

10.1101/2025.04.28.650242 — pharmacology and toxicology — Posted on 2025-05-01

5727 A Fundamental Approach to Buoyant Density Determination by DGE-AUC

Yarawsky, A. E.; Cardenas Lopez, P.; Walter, J.; DeLion, M. T.; Paul, L. N.

10.1101/2025.04.28.650698 — biophysics — Posted on 2025-05-01

5728 SquiDBase: a community resource of raw nanopore data from microbes

Cuypers, W. L.; Ceylan, H.; Turcksin, E.; Raes, L.; de Vrij, N.; Michiels, J.; Coppens, S.; de Block, T.; Jansen, D.; Arien, K. K.; Selhorst, P.; Vercauteren, K.; Gauglitz, J. M.; Bittremieux, W.; Laukens, K.

10.1101/2025.04.28.650941 — bioinformatics — Posted on 2025-05-01

5729 Variant Classification Using Proteomics-Informed Large Language Models Increases Power of Rare Variant Association Studies and Enhances Target Discovery

Gillies, C. E.; Mbatchou, J.; Habegger, L.; Kessler, M. D.; Bao, S.; Balasubramanian, S.; Delaneau, O.; Kosmicki, J. A.; Regeneron Genetics Center, ; Willer, C. J.; Kang, H. M.; Baras, A.; Reid, J.; Marchini, J.; Abecasis, G. R.; Ghoussaini, M.

10.1101/2025.04.28.650692 — bioinformatics — Posted on 2025-05-01

5730 Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters

Sakhnini, L. I.; Beltrame, L.; Fulle, S.; Sormanni, P.; Henriksen, A.; Lorenzen, N.; Vendruscolo, M.; Granata, D.

10.1101/2025.04.28.650927 — bioinformatics — Posted on 2025-05-01

5731 LC-Inspector: a simple open-source viewer for targeted hyphenated mass spectrometry analysis

Fido, M.; Hoesli, E.; Barazzone, E. C.; Zenobi, R.; Slack, E.

10.1101/2025.04.28.650946 — bioinformatics — Posted on 2025-05-01

5732 EXPRESSION GRAPH NETWORK FRAMEWORK FOR BIOMARKERDISCOVERY

Liu, Y.; Kannan, K.; Huse, J. T.

10.1101/2025.04.28.651033 — bioinformatics — Posted on 2025-05-01

5733 Influence of simplifications on FE modelling of mandible and TMJ implants

Chandra, G.; Verma, V.; Ghosh, R.; Kaur, K.; Roychoudhury, A.; Mukherjee, S.; Chawla, A.; Mukherjee, K.

10.1101/2025.04.28.651047 — bioengineering — Posted on 2025-05-01

5734 Proof-of-Concept of A DNA-Based Recording System for High-Throughput Functional Gene Screening

Kato, S.; Ikemoto, A.; Isayama, J.; Takimoto, T.; Saya, H.; Hamada, K.-i.

10.1101/2025.04.28.650920 — bioengineering — Posted on 2025-05-01

5735 Genetic architecture and cellular basis of flag leaf size variation in barley

Lapasiya, T.; Gao, Y.; Wu, P.-Y.; Haweit, A.; van Inghelandt, D.; Stich, B.; Shrestha, A.

10.1101/2025.04.28.650967 — genetics — Posted on 2025-05-01

5736 Biting time of day in malaria mosquitoes is modulated by nutritional status

Oke, C. E.; Rund, S. S. C.; Machani, M. G.; Sabtiu, A. R. M.; Akuamoah-Boateng, Y.; Afrane, Y. A.; Reece, S. E.

10.1101/2025.04.28.650966 — ecology — Posted on 2025-05-01

5737 A Conserved Venous Remodeling Program Governs Inferior Vena Cava Formation in Zebrafish

Lambiase, G.; Moshe, N.; Raanan, C.; Das, R. N.; Yaniv, K.

10.1101/2025.04.28.650985 — developmental biology — Posted on 2025-05-01

5738 Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver inflammation and hepatic fibrosis in mice

Eswaran, S.; Gebert, L.; Schraven, S.; Treichel, N. S.; Ritz, T.; Hamm, S.; Seeger, A.; Kiessling, F.; Clavel, T.; Wagner, N.; Schippers, A.

10.1101/2025.04.28.650968 — immunology — Posted on 2025-05-01

5739 Is the whole the sum of its parts? Neural computation of consumer bundle valuation in humans

Cross, L. M.; Webb, R.; O'Doherty, J. P.

10.1101/2025.04.28.650827 — neuroscience — Posted on 2025-05-01

5740 Attention to a point in time causes a suppressive wake for subsequent time points

Tkacz-Domb, S.; Yeshurun, Y.; Lindeberg, T.; Tsotsos, J. K.

10.1101/2025.04.28.651029 — neuroscience — Posted on 2025-05-01

5741 The structure of phycobilisome with a bicylindrical core from the cyanobacterium Synechococcus elongatus PCC 7942

Zhao, J.; Gao, N.; Zheng, Z.

10.1101/2025.04.28.650843 — plant biology — Posted on 2025-05-01

5742 Light-dark dependent rhythmic changes in chloroplast and mitochondrial activity in Chlamydomonas reinhardtii

Dhawan, G.; Rao, B. J.

10.1101/2025.04.28.650922 — physiology — Posted on 2025-05-01

5743 Stretchable, hair-compatible, and long-term stable wearable EEG system

10.1101/2025.04.28.651043 — bioengineering — Posted on 2025-05-01

5744 Personalized Multiscale Modeling of Left Atrial Mechanics and Blood Flow

Shi, L.; Chen, I. Y.; Vedula, V.

10.1101/2025.04.26.650771 — bioengineering — Posted on 2025-05-01

5745 MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

Arimura, Y.; Konishi, H. A.; Funabiki, H.

10.1101/2024.01.21.576499 — molecular biology — Posted on 2025-05-01

5746 Re-evaluation of the nodulation capacity of Sphingomonas sediminicola DSM 18106T indicates that this strain is not capable of inducing root nodule formation on Pisum sativum (pea)

diCenzo, G. C.; Gutmanis, S. M.; Esme, O.; Moulin, L.

10.1101/2025.04.30.650786 — microbiology — Posted on 2025-05-01

5747 Computational modeling-directed combination treatment with etanercept and mifepristone mitigates neuroinflammation in a mouse model of Gulf War Illness.

Kelly, K. A.; Felton, C. M.; Billig, B. K.; Yilmaz, A. A.; OCallaghan, J. P.; Craddock, T. J. A.; Broderick, G.; Klimas, N.; Michalovicz, L. T.

10.1101/2025.04.30.651399 — neuroscience — Posted on 2025-05-01

5748 Neurophysiological Markers of Cancer-Related Fatigue Derived from High-Density EEG

Handiru, V. S.; Suviseshamuthu, E.; Su, H.; Yue, G. H.

10.1101/2025.04.29.651322 — neuroscience — Posted on 2025-05-01

5749 INFLAMMATORY ACTIVATION, EPIGENETIC SIGNATURE AND MORPHO-STRUCTURAL ALTERATION IN A COHORT OF PATIENTS WITH CHRONIC HEART FAILURE AND PERMANENT ATRIAL FIBRILLATION: A CROSS-SECTIONAL STUDY.

Daidone, M.; Maida, C. D.; Pacinella, G.; Ferrantelli, S.; Scaglione, S.; todaro, f.; Pipitone, R.; lupo, g.; agnello, l.; Ciaccio, M.; Armentaro, G.; Sciacqua, A.; Di Chiara, T.; Di Raimondo, D.; GRIMAUDO, S.; Casuccio, A.; Tuttolomondo, A.

10.1101/2025.04.29.651356 — scientific communication and education — Posted on 2025-05-01

5750 Cultural and Ecological Dimensions of Spice Diversity: Indigenous Knowledge and Practices in Hadiya and Kambata-Tembaro, Central Ethiopia

Osie, M.

10.1101/2025.04.26.650802 — plant biology — Posted on 2025-05-01

5751 Discovery of a new evolutionarily conserved short linear F-actin binding motif

Paraschiakos, T.; Yuan, B.; Sopelniak, K.; Bucher, M.; Simon, L.; Zonjic, K.; Eggers, D.; Selle, F.; Li, J.; Linder, S.; Marlovits, T. C.; Windhorst, S.

10.1101/2025.04.16.649135 — biochemistry — Posted on 2025-05-01

5752 Separating direct, indirect and parent-of-origin genetic effects in the human population

Kraetschmer, I.; Hegemann, L. E.; Hofmeister, R.; Corfield, E. C.; Mahmoud, S. M.; Delaneau, O.; Andreassen, O. A.; Campbell, A.; Hayward, C.; Estonian Biobank Research Team, ; Marioni, R. E.; Ystrom, E.; Havdahl, A.; Robinson, M. R.

10.1101/2025.04.28.650988 — genetics — Posted on 2025-05-01

5753 Purifying Selection Shapes the Dynamics of P-element Invasion in Drosophila simulans Populations

Langmüller, A. M.; Haller, B. C.; Nolte, V.; Schlötterer, C.

10.1101/2024.12.17.628872 — evolutionary biology — Posted on 2025-05-01

5754 Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA

Gamas, K. R.; Seamons, T.; Dysart, M.; Fang, L.; Chappell, J.; Stadler, L.; Silberg, J.

10.1101/2025.04.29.651329 — synthetic biology — Posted on 2025-05-01

5755 Parallel evolution of full-length genomes in a long-term evolution experiment with phage ΦX174

Bons, E.; Chabas, H.; MacDonald, H.; Escalera Ledermann, A.; Ochsner, N.; Angst, D. C.; Bonhoeffer, S.; Regoes, R. R.

10.1101/2025.04.22.649699 — evolutionary biology — Posted on 2025-05-01

5756 Recurrent Mutations Drive the Rapid Evolution of Pesticide Resistance in the Two-spotted Spider Mite Tetranychus urticae

Cao, L.-J.; Chen, J.-C.; Thai, J.; Schmidt, T.; Ffrench-Constant, R.; Zhang, L.-X.; Yang, Y.; Yuan, M.-C.; Zhang, J.-Y.; Zhang, X.-Y.; Yang, Q.; Gong, Y.-J.; Li, H.; Chen, X.; Hoffmann, A.; Wei, S.-J.

10.1101/2025.02.06.636798 — evolutionary biology — Posted on 2025-05-01

5757 TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming

Zhu, W.; Xu, X.; Nagarajan, V.; Guo, J.; Pent, Z.; Zhang, A.; Liu, J.; Mattapallil, M. J.; Jittayasothorn, E.; Constantinides, M.; Horai, R.; Belkaid, Y.; St. Leger, A. J.; Caspi, R.

10.1101/2024.04.01.587519 — immunology — Posted on 2025-05-01

5758 Fast and Accurate Peptide - MHC Structure Prediction via an Equivariant Diffusion Model

Fruehbuss, D.; Baakman, C.; Teusink, S.; Bekkers, E.; Jegelka, S.; Xue, L. C.

10.1101/2025.04.28.650973 — bioinformatics — Posted on 2025-05-01

5759 Phylogenomic framework and virulence gene boundaries of emerging Shiga toxin producing Escherichia coli O118 informed by the comprehensive profiling of 359 O118 genomes

Rivera, I.; Konig, S. S. K.; Rodriguez, A. L.; Bosilevac, J. M.; Eppinger, M.

10.1101/2025.04.29.651274 — genomics — Posted on 2025-05-01

5760 Small pangenome of Candida parapsilosis reflects overall low intraspecific diversity

Ryan, A.; Bergin, S. A.; Scully, J.; Zuniga-Soto, E.; Hession, C.; Barber, A. E.; Gomez-Molero, E.; Bader, O.; Morio, F.; Zhai, B.; Wolfe, K. H.; Butler, G.

10.1101/2025.04.30.651475 — genomics — Posted on 2025-05-01

5761 Clade-wide proteome analysis shows widespread non-canonical Dcr proteins in fungi.

Melet, L.; Canan, J.; Villalobos, P.; Vidal-Veuthey, B.; Gonzalez-Toro, F.; Orellana, I.; Rivas-Pardo, J. A.; Cardenas, J. P.; Moraga, C.; Castro-Fernandez, V.; Johnson, N. R.; Vidal, E. A.

10.1101/2025.04.28.651110 — genomics — Posted on 2025-05-01

5762 Characterization and Genomic Analysis of vB_CoeS_P1, the First Vibrio hepatarius Phage, and Definition of the New Family Estovirdae

PK, S.; Ammini, P.; Angia Sriram, P. R.

10.1101/2025.04.29.651204 — genomics — Posted on 2025-05-01

5763 Speed Matters: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli

Ali, K. M.; Murphy, R.; Zanchi, C.; Zunk-Parras, S. A.; Rodriguez-Rojas, A.; Rolff, J.

10.1101/2025.04.25.650648 — evolutionary biology — Posted on 2025-05-01

5764 Parallel clines of chromosomal inversion in seaweed flies associated with thermal variation

Nicolas, L. A.; Berdan, E. L.; Colinet, H.; Clouard, A.; De Wit, P.; Glemin, S.; Merot, C.

10.1101/2025.04.28.650981 — evolutionary biology — Posted on 2025-05-01

5765 Single-cell analyses reveal scyphozoan conserved and specific genes contribution during tissue regeneration in two jellyfish

Li, Y.; Law, S. T. S.; Nong, W.; So, W. L.; Xie, Y.; Leung, T. C. N.; Li, T. H.; Tse, J.; Yip, H. Y.; Jin, O.; Zhang, J.; Chui, A. P.; Lau, K. F.; John, A.; Kai, Z. p.; Bendena, W. G.; Hayward, A.; Wei, Y.; Chan, T. F.; Ngai, S. M.; Hui, J. H. L.

10.1101/2025.04.29.650939 — evolutionary biology — Posted on 2025-05-01

5766 Differing drivers of range-wide genetic diversity across previously glaciated Northern hemisphere landscapes

Liu, L.; Borrell, J. S.; Wang, N. S.

10.1101/2025.04.28.650964 — evolutionary biology — Posted on 2025-05-01

5767 Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation

Cho, Y.; Taniguchi, A.; Kubo, A.; Ikenouchi, J.

10.1101/2024.09.09.612007 — cell biology — Posted on 2025-05-01

5768 Environmental fungi from cool and warm neighborhoods in the urban heat island of Baltimore City show differences in thermal susceptibility and pigmentation

Smith, D. F. Q.; Kulkarni, M.; Bencomo, A.; Faiez, T. S.; Hardwick, J. M.; Casadevall, A.

10.1101/2023.11.10.566554 — microbiology — Posted on 2025-05-01

5769 Optimizing Antimicrobial Susceptibility Testing: Cost and Environmental Benefits of MIC Volume Reduction

Clarhaut, J. A.; Moreau, J.; Collet, T.; Babiard, E.; Aranzana-Climent, V.; Marchand, S.; Brunet, K.; Buyck, J. M.

10.1101/2025.04.29.651209 — microbiology — Posted on 2025-05-01

5770 TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation

Thomas, S. M.; McGee, A. P.; Vielma, T. E.; Ankley, L. M.; Rapp, A. W.; Conner, K. N.; LeSage, F.; Tanner, C. D.; Scheeres, E. C.; Obar, J. J.; Olive, A. J.

10.1101/2024.09.04.611226 — immunology — Posted on 2025-05-01

5771 Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease

Zvyagina, V.; Kuriakose, A.; Simo, I.; Kam, J. Y.; Chakraborty, P.; Robinson, K. J.; Potapenko, A.; Watchon, M.; Paulsen, I. T.; Gamage, H. K. A. H.; Laird, A. S.

10.1101/2025.04.30.651362 — neuroscience — Posted on 2025-05-01

5772 Pathological α-Synuclein Perturbs Nuclear Integrity

Millett, M. F.; Comite, A.; Martin Castosa, E.; Heuberger, A.; Wagner, P.; Gallardo, I.; Reinhardt, J.; Chambers, N.; Hall, D.; Miller, E.; Nabert, D.; Balsamo, B.; Prokop, S.; Moehle, M.

10.1101/2025.03.04.641384 — neuroscience — Posted on 2025-05-01

5773 Accurate and fast segmentation of filaments and membranes in micrographs and tomograms with TARDIS

Kiewisz, R.; Fabig, G.; Conway, W.; Johnston, J.; Kostyuchenko, V.; Tan, A.; Barinka, C.; Clarke, O. B.; Magaj, M.; Yazdkhasti, H.; Vallese, F.; Lok, S.-m.; Redemann, S.; Muller-Reichert, T.; Bepler, T.

10.1101/2024.12.19.629196 — bioinformatics — Posted on 2025-05-01

5774 ProtRNA: A Protein-derived RNA Language Model by Cross-Modality Transfer Learning

Zhang, R.; Ma, B.; Xu, G.; Ma, J.

10.1101/2024.09.10.612218 — bioinformatics — Posted on 2025-05-01

5775 Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

Borar, P.; Biswas, T.; Chaudhuri, A.; Rao, P. T.; Raychaudhuri, S.; Huxford, T.; Chakrabarti, S.; Ghosh, G.; Polley, S.

10.1101/2023.06.27.546692 — biochemistry — Posted on 2025-05-01

5776 Ancestral and recent bursts of transposition shaped the massive genomes of plant pathogenic rust fungi

Corre, E.; Morin, E.; Duplessis, S.; Lorrain, C.

10.1101/2025.01.10.632365 — genomics — Posted on 2025-05-01

5777 Two telomere-to-telomere genome assemblies and comparisons revealed the conserved key genes associated with sugar accumulation in Rubus genus

Li, X.; Han, X.; Liu, S.; Zhang, Q.; Guan, J.; Tang, Y.; Zhang, M.; Xu, P.; Zheng, M.; Bian, J.; Li, K.; Sun, G.; Sun, Y.; Dong, Y.; Lin, X.; Wang, Z.; Zhou, H.; Yang, G.; Liu, Z.; Lian, H.; He, H.; Zhou, J.

10.1101/2025.04.09.646780 — genomics — Posted on 2025-05-01

5778 GSK-3β coordinates axonal microtubule organisation through Shot and Tau

Voelzmann, A.; Nuhu-Soso, L.; Roof, A.; Patel, S.; Bennett, H.; Adamson, A. D.; Bentley, M.; Evans, G. J. O.; Hahn, I.

10.1101/2024.09.08.611864 — cell biology — Posted on 2025-05-01

5779 Defining the ordered pathway for ZAP-mediated RNA decay

Bouton, C. R.; Gimpelj Domjanic, G.; Lista, M. J.; Galao, R. P.; Courty, T.; Wilson, H. D.; Hill, P. W. S.; Mischo, H. E.; Chakrabarti, A. M.; Poljak, M.; Ule, J.; Neil, S. J. D.; Swanson, C. M.

10.1101/2025.04.28.650959 — immunology — Posted on 2025-05-01

5780 Response metrics of T-cell activation models

Rey Barreiro, X.; Faro, J.; Villaverde, A. F.

10.1101/2025.04.28.650960 — systems biology — Posted on 2025-05-01

5781 PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and Tamoxifen in a luminal A breast cancer model

Schwarzmueller, L.; Mueller, J.; Vlachavas, E.-I.; Beumers, L.; Fleischhacker, L.; Burmester, S.; Helm, D.; Koerner, C.; Wiemann, S.

10.1101/2025.04.28.651009 — cancer biology — Posted on 2025-05-01

5782 An image analysis pipeline to quantify the spatial distribution of cell markers in stroma-rich tumors

Ruzette, A. A.; Kozlova, N.; Cruz, K. A.; Muranen, T.; Norrelykke, S. F.

10.1101/2025.04.28.650414 — bioinformatics — Posted on 2025-05-01

5783 Vaginal bacteria-derived extracellular vesicles diffuse through human cervicovaginal mucus to enable bacterial signaling to upper female reproductive tract tissues

Steinman, D.; Chibber, Y.; Petersen, A. P.; Zierden, H. C.

10.1101/2025.04.28.651063 — bioengineering — Posted on 2025-05-01

5784 Buying time - increasing yield potential in wheat by extending stem elongation duration

Kronenberg, L.; Gonzalez-Navarro, O. E.; Collier, S.; Chhetry, M.; Tailby, P.; Leverington-Waite, M.; Wingen, L. U.; Griffiths, S.

10.1101/2025.04.28.650957 — genetics — Posted on 2025-05-01

5785 Neurogliaform cells mediate interhemispheric modulation of sensory-evoked activity in cortical pyramidal neurons

Markopoulos, F.; Chrereau, R.; Brandalise, F.; Chippalkatti, V.; Prados, J.; Dayer, A.; Holtmaat, A.

10.1101/2025.04.30.651595 — neuroscience — Posted on 2025-05-01

5786 Sleep is associated with reduction of excitatory signaling in medial prefrontal cortex

Yamada, T.; Cochrane, A.; Labonte-Clark, T.; Watanabe, T.; Sasaki, Y.

10.1101/2025.04.29.651178 — neuroscience — Posted on 2025-05-01

5787 Perceptual prediction error supports implicit process in motor learning.

Zhang, X.; Wei, K.

10.1101/2025.04.29.651214 — neuroscience — Posted on 2025-05-01

5788 An Eocene Origin of Passerine Birds Estimated Using Bayesian Tip Dating with Fossil Occurrences

Luo, A.; Nguyen, J. M. T.; Zhou, Q.-S.; Zhu, C.-D.; Ho, S. Y. W.

10.1101/2025.04.28.650918 — evolutionary biology — Posted on 2025-05-01

5789 How does urbanization shape shell phenotype, behaviour and parasite prevalence in the snail Cornu aspersum?

Dahirel, M.; de Tombeur, Y.; Gerard, C.; Ansart, A.

10.1101/2025.01.10.632424 — ecology — Posted on 2025-05-01

5790 Tbr2-Dependent Parallel Pathways Regulate the Development of Distinct ipRGC Subtypes

Kiyama, T.; Chen, C.-K.; Altay, H. Y.; Chen, Y.-J.; Sigala, L.; Su, D.; Eliason, S. L.; Amendt, B.; Mao, C.-A.

10.1101/2025.04.29.651262 — developmental biology — Posted on 2025-05-01

5791 ImmunoStruct: a multimodal neural network framework for immunogenicity prediction from peptide-MHC sequence, structure, and biochemical properties

Givechian, K. B.; Rocha, J. F.; Yang, E.; Liu, C.; Greene, K.; Ying, R.; Caron, E.; Iwasaki, A.; Krishnaswamy, S.

10.1101/2024.11.01.621580 — immunology — Posted on 2025-05-01

5792 In-phase and anti-phase dual-site beta tACS differentially influence functional connectivity and motor inhibition

Zhu, T.; Sack, A. T.; Leunissen, I.

10.1101/2025.04.28.651005 — neuroscience — Posted on 2025-05-01

5793 HPDL is critical in human cortical development via regulation of mitochondrial functional properties

Baggiani, M.; Desbats, M. A.; Naef, V.; Giacich, M.; Galatolo, D.; Mero, S.; Zampieri, S.; Cappello, V.; Valentino, A.; Salviati, L.; Santorelli, F. M.; Damiani, D.

10.1101/2025.04.28.651017 — neuroscience — Posted on 2025-05-01

5794 Astrocyte-derived PTPRZ1 regulates astrocyte morphology and excitatory synaptogenesis

Eaker, A. R.; Spence-Osorio, H. E.; Baldwin, K. T.

10.1101/2025.04.30.651514 — neuroscience — Posted on 2025-05-01

5795 PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour

Novelli, L.; Stoliker, D.; Barta, T.; Greaves, M. D.; Chopra, S.; Jackson, J.; Kwee, J.; Williams, M.; Razi, A.

10.1101/2025.04.11.643415 — neuroscience — Posted on 2025-05-01

5796 Cross-species Standardised Cortico-Subcortical Tractography

Assimopoulos, S.; Warrington, S.; Folloni, D.; Bryant, K.; Tang, W.; Jbabdi, S.; Heilbronner, S.; Mars, R. B.; Sotiropoulos, S. N.

10.1101/2025.04.29.651254 — neuroscience — Posted on 2025-05-01

5797 Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP

Kirk, L. M.; Garcia, G. C.; Zatyko, K.; Bartol, T. M.; Sejnowski, T. J.; Harris, K. M.

10.1101/2025.04.29.651313 — neuroscience — Posted on 2025-05-01

5798 3D multimodal histological atlas and coordinate framework for the mouse brain and head

Tward, D. J.; Flannery, P. J.; Savoia, S.; Mezias, C.; Banerjee, S.; Richman, M.; Lodato, B.; O'Rourke, J. R.; Balani, S.; Arima, K.; Washington, S.; Coronado-Leija, R.; Zhang, J.; Mitra, P. P.

10.1101/2025.04.30.650246 — neuroscience — Posted on 2025-05-01

5799 Perturbational fitness analysis of CRISPR screens uncovers information-theoretic relation between gene function and selection

Andersen, A. N.; Chica, N.; Piechaczyk, L.; Nakken, S.; Zucknick, M.; Enserink, J. M.

10.1101/2025.04.29.651199 — systems biology — Posted on 2025-05-01

5800 Comparable Strength and Hypertrophic Adaptations to Low-Load and High-Load Resistance Exercise Training in Trained Individuals: Many Roads Lead to Rome

Toldnes Cumming, K.; Elvatun, I. C.; Kalenius, R.; Divljak, G.; Raastad, T.; Psilander, N.; Horwath, O.

10.1101/2025.04.28.650925 — physiology — Posted on 2025-05-01

5801 Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

Ahmad, F.; White, M.; Yamamoto, K.; Crooks, D. R.; Agarwal, S.; Yang, Y.; Capaldo, B.; Raj, S.; Alilin, A. N.; Ton, A.; Adler, S.; Seidel, J.; Olkowski, C.; Cherukuri, M. K.; Choyke, P. L.; Kelly, K.; Brender, J. R.

10.1101/2023.11.15.567250 — cancer biology — Posted on 2025-05-01

5802 Regioselective Rapid Ene-type Reaction (RRER) Enables Bioconjugation of Histone Serotonylation

Wu, J.; Li, H.; Lovato, A.; Symasek, A.; Zheng, Q.

10.1101/2025.04.22.650073 — biochemistry — Posted on 2025-05-01

5803 FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

Smith, R. C.; Clark, M.; Vazquez-Prada, M.; Astick, M.; Tubby, K. C.; Price, S. R.

10.1101/2025.04.30.651488 — developmental biology — Posted on 2025-05-01

Archive, 2025-05