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Archive, 2025-05

2 Heightened Sensitivity to Voice Loudness Changes in Parkinson's Disease
Contreras Ruston, F.; Criscuolo, A.; Callen, A.; Cucurell, D.; Navarra, J.; Kotz, S. A.
10.1101/2025.05.29.656769 — neuroscience — Posted on 2025-05-30
4 Resolving the full set of human polymorphic inversions and other complex variants from ultra-long read data
Moreira-Pinhal, R.; Karakostis, K.; Yakymenko, I.; Conchillo, O.; Diaz-Ros, M.; Santos, A.; Senar, M. A.; Martinez-Urtaza, J.; Puig, M.; Caceres, M.
10.1101/2025.05.27.656315 — genomics — Posted on 2025-05-29
5 STARD3 coordinates Endoplasmic Reticulum-late endosome/lysosome contacts and organelle positioning through a GSK3-regulated phosphorylation switch
Eichler, J.; Wendling, C.; Huver, S.; Zouiouich, M.; Hanss, V.; Cardinal, A.; Fimbel, V.; Birck, C.; McEwen, A. G.; Knorr, C.; Fromental-Ramain, C.; Boutry, M.; Chenard, M.-P.; DRIN, G.; Tomasetto, C.; ALPY, F.
10.1101/2025.05.29.656564 — cell biology — Posted on 2025-05-30
7 Multifaceted brain representation of numerosity across the senses and presentation formats
Yang, Y.; Fornaciai, M.; Togoli, I.; Shahzad, I.; Gau, R.; Van Audenhaege, A.; Cerpelloni, F.; Collignon, O.
10.1101/2025.05.29.653470 — neuroscience — Posted on 2025-05-29
10 Cholinergic disruption of state-dependent retrosplenial layer 1 activity causes temporal associative memory deficit under stress
Tanimura, A.; Login, H.; Feld-Jakobsen, S. O.; Hou, W.-H.; Gunnink, H.; Nakamoto-Griffiths, C.; Overmark, T.; Radulovic, J.; Yamawaki, N.
10.1101/2025.05.27.656297 — neuroscience — Posted on 2025-05-29
13 Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome
Almassalha, L. M.; MacQuarrie, K.; Carignano, M.; Dunton, C.; Gong, R.; Ibarra, J.; Carter, L.; Li, W. S.; Nap, R.; Dulai, P. S.; Szleifer, I.; Backman, V. m.
10.1101/2025.05.29.656862 — biophysics — Posted on 2025-05-29
14 The development of trait anxiety in nonhuman primates during the first year of life
Puralewski, R. F.; Aggarwal, N.; Oler, J.; Roseboom, P. H.; Parkins, L.; Riedel, M. K.; Boettcher, C.; Kalin, N. H.
10.1101/2025.05.29.654506 — animal behavior and cognition — Posted on 2025-05-29
15 Modulation of Filopodial Myosin Function
Crawford, A.; Schwartz, J. K.; Hall, E.; Houdusse, A.; Titus, M. A.
10.1101/2025.05.29.656896 — cell biology — Posted on 2025-05-29
16 Understanding the Role of Pyruvate Dehydrogenase in Listeria monocytogenes Virulence
Freeman, M. J.; Eral, N. J.; Debrine, A. M.; Stevenson, D. M.; Amador-Noguez, D.; Sauer, J.-D.
10.1101/2025.05.29.656449 — microbiology — Posted on 2025-05-29
17 The ATO gene family governs Candida albicans colonisation in the dysbiotic gastrointestinal tract
Alves, R.; Ghasemi, F.; Van Genecthen, W.; Wijnants, S.; Van Goethem, O.; Barata-Antunes, C.; Fernandes, V.; Ataide, P.; Gomes-Goncalves, A.; Vergauwen, R.; Ma, Q.; Duarte, R.; Soares-Silva, I.; Casal, M.; Brown, A. J.; Van Dijck, P.; Paiva, S.
10.1101/2025.05.29.656788 — microbiology — Posted on 2025-05-29
19 Synthesis of C8-vinyl chlorophylls d and f impairs far-red light photoacclimation and growth under far-red light
Chaudhary, A. K.; Fuchs, L. K.; Pawlak, K.; Dykes, G. F.; Goodacre, R.; Nürnberg, D. J.; Canniffe, D. P.
10.1101/2025.05.26.656186 — biochemistry — Posted on 2025-05-29
21 Tirzepatide reduces diet-induced senescence and NETosis-mediated liver fibrosis in mice
Chen, F.; Nam, Q.; Wang, L. D.; Chammas, F.; Wuestefeld, T.; Lee, B. T. K.; Wong, S. L.
10.1101/2025.05.27.656284 — molecular biology — Posted on 2025-05-29
24 Dynamics and fermentation patterns of stool microbiota on simple carbon sources in in vitro batch cultures reveal dysbiosis in Crohn's disease.
Detman-Ignatowska, A.; Schiro, G.; Filip, R.; Samborowska, E.; Karczmarski, J.; Jakubowska, K.; Jarmakiewicz-Czaja, S.; Williams, A.; Hickman, N. R.; Laubitz, D.; Sikora, A.
10.1101/2025.05.29.656803 — microbiology — Posted on 2025-05-29
25 Proximity biotinylation at the host-Shigella interface reveals UFMylation as an antibacterial pathway.
Jimenez, A. T. L.; Thery, F.; Wright, K.; Painter, H.; Hoffmeister, S. T.; Jarche, L.; Benjamin, J.; van der Heden van Noort, G. J.; Brokatzky, D.; Gomes, M. C.; Miles, S. L.; Lobato-Marquez, D.; Rohde, J.; Pruneda, J. N.; Impens, F.; Mostowy, S.
10.1101/2025.05.29.656827 — microbiology — Posted on 2025-05-29
30 MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos
Carey, C. M.; Parvez, S.; Brandt, Z. J.; Bisgrove, B. W.; Yates, C. J.; Peterson, R. T.; Gagnon, J. A.
10.1101/2025.05.27.656468 — genomics — Posted on 2025-05-29
31 A genomic catalog of Earth's bacterial and archaeal symbionts
Villada, J. C.; Vasquez, Y.; Szabo, G.; Walker, E. W.; Gutierrez, M. R.; Qin, S.; Varghese, N.; Eloe-Fadrosh, E. A.; Kyrpides, N.; SymGs data consortium, ; Visel, A.; Woyke, T.; Schulz, F.
10.1101/2025.05.29.656868 — genomics — Posted on 2025-05-29
33 Mechanisms and timing of programmed DNA elimination in songbirds
Dedukh, D.; Malinovskaya, L.; Kauzal, O.; Ridl, J.; Odnoprienko, D.; Karamysheva, T.; Vontzou, N.; Janko, K.; Suh, A.; Albrecht, T.; Torgasheva, A.; Reifova, R.
10.1101/2025.05.26.656170 — genetics — Posted on 2025-05-29
36 Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq
Tomuro, K.; Akaiwa, T.; Harada, A.; Kobayashi, K.; Shiina, N.; Kawaguchi, K.; Shichino, Y.; Iwasaki, S.
10.1101/2025.05.26.656194 — molecular biology — Posted on 2025-05-29
37 Picophytoplankton Implicated in Productivity and Biogeochemistry in the North Pacific Transition Zone
Key, R. S.; Coesel, S. N.; Gradoville, M. R.; Morales, R. L.; Farnelid, H.; Zehr, J.; Armbrust, V.; Durham, B.
10.1101/2025.05.29.656823 — microbiology — Posted on 2025-05-29
40 Two birds with one stone: a novel potential antibiotic blocking IsdB-mediated heme extraction by Staphylococcus aureus with serendipitous hemoglobin left-shifting activity
Hijazi, S.; Marchesani, F.; Marchetti, M.; Buoli Comani, V.; Brear, P.; Campanini, B.; Ronda, L.; Faggiano, S.; Gianquinto, E.; Asgharpour Hassankiadeh, S.; Rolando, B.; Spyrakis, F.; Compari, C.; Lazzarato, L.; De Bei, O.; Frangipani, E.; Bettati, S.
10.1101/2025.05.29.656759 — microbiology — Posted on 2025-05-29
41 The Quantification of Drug Accumulation within Gram-Negative Bacteria
George, A.; Shivangi, F.; Bozan, A.; Spencer, K.; Terlecky, A. J.; Ahn, Y.-M.; Barnett, P. R.; Kreiswirth, B. N.; Freundlich, J. S.
10.1101/2025.05.28.656715 — microbiology — Posted on 2025-05-29
44 Development and optimisation of Influenza C and Influenza D pseudotyped viruses
Marotta, M. G.; Neto, M. M.; Daly, J. M.; Maina, M.; van Diemen, P.; Everett, H.; Lucente, M. S.; Camero, M.; Montomoli, E.; Trombetta, C. M.; da Costa, K.; Temperton, N.
10.1101/2025.05.26.656172 — immunology — Posted on 2025-05-29
47 The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation
Lambrechts, L. S.; Reid, X. J.; Kambanis, L.; Luong, C.; Kobakhidze, E.; Daners, A.; Zhong, Y.; Patel, K.; Franck, C. K.; Sani, H. M.; Taylor, C.; Low, J. K.; Payne, R. J.; Mackay, J. P.
10.1101/2025.05.29.656505 — biochemistry — Posted on 2025-05-29
48 Establishing a Digital PCR-Based Reference Measurement Procedure for Monkeypox Virus: An Inter-laboratory Assessment and Standardization Study
Wang, X.; Li, H.; Guo, R.; Yang, Y.; Niu, C.; Zhou, S.; Gao, H.; Jin, X.; Wang, S.; Du, M.; Cheng, X.; Zhu, L.; Dong, L.
10.1101/2025.05.28.656494 — molecular biology — Posted on 2025-05-29
49 Whole blood proteome dynamics defines predictive diagnostic and prognostic signatures of cryptococcal infection
Geddes-McAlister, J.; Woods, M.; McAlister, J. A.; Segeren, L.; Silva, M.; Deyarmin, J.; Hakimi, A.; Hermanson, D.; Richter, J.; Samra, S.
10.1101/2025.05.29.656814 — microbiology — Posted on 2025-05-29
52 A mathematical framework to correct for compositionality in microbiome datasets
Forry, S. P.; Servetas, S. L.; Kralj, J. G.; Hunter, M. E.; Dootz, J. N.; Jackson, S. A.
10.1101/2025.05.29.656792 — microbiology — Posted on 2025-05-29
53 Varied mutual growth inhibition between commensal yeasts and strains
Pingault--Ordronneau, E.; Francois, A.; Ragoobeer, V.; Chambon, T.; Cockx, B.; Elias, A. J.; Szabo, D.; Gugolya, M.; Kreft, J.-U.; Cloteau, C.; Levercan, D.; Croyal, M.; Delhaye, T.; Rondeau, D.; Roullier, C.; Bertrand, S.; Picot, C.; Le Pape, P.; Batard, E.; Alvarez-Rueda, N.
10.1101/2025.05.29.656793 — microbiology — Posted on 2025-05-29
54 Dynamic changes in the plasmidome and resistome in the gastrointestinal tract of chickens
Rysava, M.; Palkovicova, J.; stredanska, k.; Schwarzerova, J.; Jakubickova, M.; Cejkova, D.; Aytan-Aktug, D.; Otani, S.; Dolejska, M.
10.1101/2025.05.29.656840 — microbiology — Posted on 2025-05-29
57 Immunological evaluation in African Green Monkeys of two nasal vaccine candidates to induce a broad immunity against coronaviruses
Lazo, L.; Suzarte Portal, E.; Vazquez-Blomquist, D.; Rodriguez-Alonso, I.; Perez Fuente, Y.; Puente Perez, P.; Martinez Castillo, R.; Urquiza Noa, D.; Amaya Izquierdo, R.; Bequet-Romero, M.; Romero Fernandez, Y.; Hernandez-Delgado, J.; Chen, R.; Li, W.; Guillen, G.; Perera, Y.; Lobaina, Y.; Hermida, L.
10.1101/2025.05.28.656401 — immunology — Posted on 2025-05-29
58 Predictive Modeling of Immune Escape and Antigenic Grouping of SARS-CoV-2 Variants
Nasir, A.; Lee, D.; Avena, L. E.; Montes Berrueta, D.; Speidel, T.; Wu, K.; Budigi, Y.; Carfi, A.; Stewart-Jones, G. B. E.; Edwards, D. K.
10.1101/2025.05.28.656328 — immunology — Posted on 2025-05-29
61 Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction
Schipper, K.; Tamminga, S. M.; Murner, N.; Davies, M. A.; Berkhout, P.; Bessen, D. E.; Hendriks, A.; Korotkova, N.; Pannekoek, Y.; van Sorge, N. M.
10.1101/2024.11.04.621835 — microbiology — Posted on 2025-05-29
62 Marker genes for predicting cytokine release syndrome in vitro before CAR T cell infusion
Chen, M.; Wu, T.; Hu, Y.; Liu, Q.; Chen, M.; Zhang, J.; Du, Y.; Ouyang, F.; Huang, Y.
10.1101/2025.05.26.655341 — immunology — Posted on 2025-05-29
63 Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis
Barath, A. S.; Dheer, A.; Dale, E.; Goche, F.; Nguyen, T. T. L.; Montier, L.; Akter, M.; Peshoff, M.; Qi, F.; Umpierre, A. D.; Bosco, D. B.; Haruwaka, K.; Sah, R.; Wu, L.-J.
10.1101/2025.05.26.656163 — neuroscience — Posted on 2025-05-29
73 Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models
Brunialti, E.; Villa, A.; Szego, E. M.; La Vitola, P.; Drago, D.; Pavlovic, R.; Fontana, L.; Tuna, D.; Panzeri, A.; Meda, C.; Rondinone, O.; Pitasi, M.; Miozzo, M.; Andolfo, A.; Di Monte, D. A.; Ciana, P.
10.1101/2025.05.26.656111 — neuroscience — Posted on 2025-05-29
74 CoREST Complex Stabilizes MYC Protein to Promote Cancer Cell Genome Stability
Khan, A. A.; Kim, S.; Sidrat, T.; Byun, J.; Aptekmann, A. A.; Dalerba, P. D.; Zakrzewski, J. L.; Shin, J.; Ryu, B.
10.1101/2024.12.23.630174 — cancer biology — Posted on 2025-05-29
76 Testing for the genomic footprint of conflict between life stages in an angiosperm and moss species
Yuan, M.; Kollar, L. M.; Sacchi, B. M.; Carey, S. B.; Choudhury, B. I.; Jones, T.; Grimwood, J.; Barrett, S. C.; McDaniel, S. F.; Wright, S. I.; Stinchcombe, J. R.
10.1101/2024.10.04.613734 — evolutionary biology — Posted on 2025-05-29
78 Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation
Swann, J. W.; Fung, J. H.; Chen, Z.; Olson, O. C.; Collins, A.; Lhakhang, T.; Proven, M. A.; Zhang, R.; Rabadan, R.; Passegue, E.
10.1101/2025.05.28.656712 — cell biology — Posted on 2025-05-29
80 Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection
Alhussien, M.; Vikkula, H. K.; Klinger, R.; Zenner, C.; Frueh, S. P.; Negi, R.; von Heyl, T.; Schleibinger, S.; Brunner, M.; Berghof, T. V.; Avolio, L.; Reich, A.; Schade, B.; Aboukhadra, B.; Rautenschlein, S.; Preisinger, R.; Sid, H.; Schusser, B.
10.1101/2025.01.24.634794 — immunology — Posted on 2025-05-29
81 Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development
Habib, R.; Roark, R. S.; Li, H.; Connell, A. J.; Hogarty, M. P.; Wagh, K.; Wang, S.; Marchitto, L.; Skelly, A. N.; Carey, J. W.; Sowers, K. J.; Ayyanathan, K.; Plante, S. J.; Bibollet-Ruche, F.; Park, Y.; Agostino, C. J.; Singh, A.; Martella, C. L.; Lewis, E.; Rando, J. M.; Chohan, N.; Lora, J.; Ding, W.; Campion, M. S.; Zhao, C.; Liu, W.; Li, Y.; Li, X.; Liang, B.; Chowdhury, R. R.; Amereh, K.; Van Itallie, E.; Sheng, Z.; Ghosh, A. R.; Bar, K. J.; Williams, W. B.; Wiehe, K.; Saunders, K. O.; Edwards, R. J.; Cain, D. W.; Lewis, M.; Batista, F. D.; Burton, D. R.; Andrabi, R.; Kulp, D. W.; Hayne
10.1101/2025.05.03.652068 — immunology — Posted on 2025-05-29
89 Genetic regulation of fatty acid content in adipose tissue
Yan, X.; Roberts, A. L.; El-Sayed Moustafa, J. S.; Villicana, S.; Al-Hilal, M.; Tomlinson, M.; Menni, C.; Sanders, T. A.; Freydin, M. B.; Bell, J. T.; Small, K. S.
10.1101/2025.05.28.655990 — genetics — Posted on 2025-05-29
90 CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS
Almeida-Santos, G.; Santiago-Carvalho, I.; Almeida, F. M.; Bomfim, C. C. B.; Santos e Silva, J. C.; Cantarini, D. G.; Silva, C. R.; Ribeiro, M. S.; Macedo, B. d. G.; Raeder, P. H. L.; Teixeira-Xavier Junior, J.; Alvarez, J. M.; Hirata, M. H.; Coutinho-Silva, R.; Robson, S. C.; Amaral, E. P.; Lasunskaia, E.; Lima, M. R. D. I.
10.1101/2025.05.28.656614 — immunology — Posted on 2025-05-29
91 Transcranial direct current stimulation over the frontal eye field has no effect on visual search performance
Peylo, C.; Albrecht, C.; Homann, R. G.; Richter, J.; Dornier, M. A.; Ehrat, M. S.; Loeb, F. L.; Manz, S.; Gaeta, M. P.; Rieger, C.; Tafelmaier, J. C.; Sauseng, P.
10.1101/2025.05.27.656327 — neuroscience — Posted on 2025-05-29
92 The SAFE Labs Handbook: community-driven commitments for group leaders to improve lab culture
Dona, E.; Gahan, J. M.; Lau, P.; Jeschke, J.; Ott, T.; Reinhard, K.; Sinigaglia, C.; Treur, J. L.; Vogl, T.; Bugeon, S.; Mariotti, L.; Rossi, F. F.; Coen, P.
10.1101/2025.05.27.655799 — scientific communication and education — Posted on 2025-05-29
93 DoggifAI: a transformer based approach for antibodycaninisation
Grabarczyk, D.; Kocikowski, M.; Parys, M.; Houston, D.; Hupp, T.; Alfaro, J. A.; Cohen, S.
10.1101/2025.05.28.656573 — bioinformatics — Posted on 2025-05-29
95 obABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors
Jones, H. B. L.; Draganov, S. D.; Schonbauer Huaman, S.; Wing, P. A.; Nguyen, C.; Liang, Z.; Dorner, J.; Lithgow, J.; Murphy, E.; Beard, A.; Pierangelini, A.; Houghton, J. W.; Robert, M. E.; Flannery, S.; Tumber, A.; Vendrell, I.; Tate, E. W.; Elliott, P. R.; West, G. M.; O'Brien, D. P.; Salah, E.; Turnbull, A. P.; Schofield, C. J.; Kessler, B. M.; Brewitz, L.; Pinto-Fernandez, A.
10.1101/2025.05.27.656269 — biochemistry — Posted on 2025-05-29
99 Computational design of monomeric Fc variants with distinct pH-responsive FcRn-binding profiles
Jeon, J.-Y.; Lee, H.; Choi, S.; Suh, S.; Im, S.-B.; Kim, Y.-G.; Ku, B. M.; Ahn, M.-J.; Jeong, B.-s.; Oh, B.-H.
10.1101/2025.05.26.656075 — bioengineering — Posted on 2025-05-29
100 Genetically Programmable Adhesive Protein Hydrogels for Sealing Perforating Corneal Trauma
Xu, L.; Yi, Q.; Hu, P.; Yu, Y.; Huang, Y.; Ye, Y.; Chen, H.; Fok, H. K. F.; Zhao, P.; Wu, X.; Kou, S.; Zhou, Z.; Sun, F.; Long, D.
10.1101/2025.05.26.656098 — bioengineering — Posted on 2025-05-29
104 What if wildlife health surveillance was not just for veterinarians? - Opportunistic use of population monitoring by camera traps for syndromic surveillance of the Eurasian lynx (Lynx lynx)
Lenglin, L.; Chenesseau, D.; Blin, L.; BASTIAN, S.; Borel, S.; Ryser-Degiorgis, M.-P.; Zimmermann, F.; Toulet, N.; Lemberger, K.; Gourlay, P.; Decors, A.
10.1101/2025.05.26.656112 — ecology — Posted on 2025-05-29
106 Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis
Neppelenbroek, S.; Wortel, C. M.; van Rijswijck, D. M. H.; Wetzels, M. J. A. L.; Kim, R. Q.; Levarht, N. E. W.; Heck, A. J. R.; de Vries-Bouwstra, J. K.; Fehres, C. M.; Toes, R. E. M.; Scherer, H. U.
10.1101/2025.05.26.656088 — immunology — Posted on 2025-05-29
108 Multi-Stable Bimodal Perceptual Coding within the Ventral Premotor Cortex
Andrade-Ortega, B.; Diaz, H.; Bayones, L.; Alvarez, M.; Zainos, A.; Rivera-Yoshida, N.; Franci, A.; Romo, R.; Rossi-Pool, R.
10.1101/2024.12.11.628069 — neuroscience — Posted on 2025-05-29
112 From lab to field: analyses of genome-edited bacterial blight resistant rice
Frommer, W. B.; Loo, E. P.; Huguet-Tapia, J. C.; Selvaraj, M.; Stiebner, M.; Killing, B.; Buchholzer, M.; Schepler-Luu, V.; Hartwig, T.; Valdez Gutierrez, S.; Rast-Somssich, M. I.; Szurek, B.; Tohme, J.; Charraviaga, P.; White, F. F.; Yang, B.
10.1101/2025.05.26.656110 — plant biology — Posted on 2025-05-29
115 A deeper study on propionic acid-related inhibition during anaerobic digestion: insights on methane production and identification of biomarker candidates for an early warning
Liu, X.; Soulard, C.; Jamilloux, V.; Pauss, A.; Andre, L.; Ribeiro, T.; Guerin-Rechdaoui, S.; Rocher, V.; Lacroix, C.; Bureau, C.; Midoux, C.; Chapleur, O.; Bize, A.; Roose-Amsaleg, C.
10.1101/2025.05.26.656080 — bioengineering — Posted on 2025-05-29
117 Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors
Mishra, S.; Yadav, M. K.; Dalal, A.; Ganguly, M.; Yadav, R.; Sawada, K.; Tiwari, D.; Roy, N.; Banerjee, N.; Fung, J. N.; Marallag, J.; Cui, C. S.; Li, X. L.; Lee, J. D.; Dsouza, C. A.; Saha, S.; Sarma, P.; Rawat, G.; Zhu, H.; Khant, H. A.; Clark, R. J. J.; Sano, F. K.; Banerjee, R.; Woodruff, T. M.; Nureki, O.; Gati, C.; Shukla, A. K.
10.1101/2025.05.26.656101 — biochemistry — Posted on 2025-05-29
118 Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry
Shamorkina, T. M.; Paneda, L. P.; Kadava, T.; Schulte, D.; Pribil, P. A.; Heidelberger, S.; Narlock-Brand, A. M.; Yannone, S. M.; Snijder, J.; Heck, A. J. R.
10.1101/2025.05.26.656138 — biochemistry — Posted on 2025-05-29
122 Meningeal vascular Aβ deposition associates with cerebral hypoperfusion and compensatory collateral remodeling
Kaloss, A. M.; Browning, J. L.; Li, J.; Pan, Y.; Watsen, S.; Sontheimer, H.; Theus, M. H.; Olsen, M. L.
10.1101/2025.02.05.635937 — neuroscience — Posted on 2025-05-29
123 3BTRON: A Blood-Brain Barrier Recognition Network
Fletcher-Lloyd, N. V.; Bravo-Ferrer, I.; Gaasdal-Bech, K.; Diaz Castro, B.; Barnaghi, P.
10.1101/2025.02.12.637854 — neuroscience — Posted on 2025-05-29
124 The striatal heterogeneous nuclear ribonucleoprotein H mRNA targetome associated with methamphetamine administration and behavior
Ruan, Q. T.; Lynch, W. B.; Cole, R. H.; Rieger, M. A.; Baskin, B. M.; Miracle, S. A.; Beierle, J. A.; Yao, E. J.; Cox, J. W.; Kandola, A.; Richardson, K. T.; Chen, M. M.; Kelliher, J. C.; Babbs, R. K.; Ash, P. E. A.; Wolozin, B.; Szumlinski, K. K.; Johnson, W. E.; Dougherty, J. D.; Bryant, C. D.
10.1101/2021.07.06.451358 — neuroscience — Posted on 2025-05-29
129 Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries
Hanna, A. R.; Shepherd, S. J.; Datto, G. A.; Navarro, I. B.; Ricciardi, A.; Padilla, M.; Srikumar, N.; Zhang, S.; Yamagata, H.; Meng, N.; Buser, J. R.; MITCHELL, M.; Issadore, D.
10.1101/2025.05.26.656157 — bioengineering — Posted on 2025-05-29
130 Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity
Lee, J.; Jeon, E. Y.; Yu, L.; Jo, H.-Y.; Kim, S. C.; Park, W.-Y.; Park, H.-Y.; Zhao, S.; Choi, M.
10.1101/2024.12.18.629144 — genetics — Posted on 2025-05-29
131 Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Collins, M. A.; Friedrich, C.; Elcheikhali, M.; Stewart, P.; Derks, J.; Connors Stewart, T.; Altig, K.; Melloni, A.; Petelski, A.; Oakley, D.; Hyman, B.; Slavov, N.
10.1101/2025.05.29.656728 — neuroscience — Posted on 2025-05-29
132 AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers
Lee, J. W.; Shi, J.; Barrantes, J.; Chaurasia, P.; Kim, S.; Cruz-Gomez, S.; Yang, C.; Gu, J.; Zhao, H.; Zhao, D.; Schiff, B.; Roche, A.; Perry, E. B.; Townsend, J. P.; Kupfer, G. M.; Politi, K.; Golemis, E.; Burtness, B.
10.1101/2025.05.28.656693 — cancer biology — Posted on 2025-05-29
134 Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety and degeneracy at the heart of learning.
Confavreux, B.; Harrington, Z.; Kania, M.; Ramesh, P.; Krouglova, A. N.; Bozelos, P.; Macke, J. H.; Saxe, A. M.; Goncalves, P. J. H.; Vogels, T. P.
10.1101/2025.05.28.656584 — neuroscience — Posted on 2025-05-29
141 REGULATION OF HDL DYSFUNCTIONALITY BY PHOSPHATIDYLETHANOLAMINE LINKS POLY-UNSATURATED FATTY ACIDS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASES
Taradeh, M.; Hardy, L. M.; Dahik, V. D.; Lhomme, M.; Wang, H.; Reydellet, C.; Materne, C.; KC, P.; Bun, E.; Clemessy, M.; Pais-De-Barros, J.-P.; Galier, S.; Frisdal, E.; Durand, H.; Ponnaiah, M.; El Khoury, P.; Villard, E. F.; Lesnik, P.; Gallo, A.; Kappeler, L.; Giral, P.; Bruckert, E.; Masson, D.; Guerin, M.; Kontush, A.; Guillas, I.; Le Goff, W.
10.1101/2025.05.27.656492 — cell biology — Posted on 2025-05-29
143 GNAT family Pat2 lysine acetylation of glycerol kinase and its key role in glycerol metabolism in hypersaline-adapted archaea
Judd, H. N.; Sanchez, K. M.; Dublino, L. S.; Zhang, G. J.; Gal, D.; Couto-Rodriguez, R. L.; Maupin-Furlow, J. A.
10.1101/2025.05.27.656527 — microbiology — Posted on 2025-05-29
144 eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small molecules
Purdy, S. C.; Matlin, K.; Alderman, C.; Baldwin, A.; Shrivastava, N.; Dutta, S.; Webb, K. J.; Wolin, A.; Boulton, D. P.; Kapali, J.; Landau, J. D.; Lewis, M. T.; Caino, M. C.; Costello, J. C.; Old, W.; Wang, X.; Zhao, R.; Ford, H. L.; Mukherjee, N.
10.1101/2025.05.29.656739 — cancer biology — Posted on 2025-05-29
148 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-05-29
150 Caspase-8 is a novel modulator of Homologous Recombination Repair in response to ionizing radiations
Barila, D.; Contadini, C.; Ferri, A.; Di Girolamo, C.; Cirotti, C.; Fiscon, G.; Paci, P.; Marzullo, M.; Gentileschi, M.; Yamamoto, T.; Strauss, R.; Del Bufalo, D.; Ciapponi, L.
10.1101/2025.05.26.656091 — cancer biology — Posted on 2025-05-29
151 ArtiDock: accurate Machine Learning approach to protein-ligand docking optimized for high-throughput virtual screening
Voitsitskyi, T.; Koleiev, I.; Stratiichuk, R.; Kot, O.; Kyrylenko, R.; Savchenko, I.; Husak, V.; Yesylevskyy, S.; Starosyla, S.; Nafiiev, A.
10.1101/2024.03.14.585019 — bioinformatics — Posted on 2025-05-29
152 H3K4me2 orchestrates H2A.Z and Polycomb repressive marks in Arabidopsis
Noyori, T.; Mori, S.; Oya, S.; Nishio, H.; Kudoh, H.; Inagaki, S.; Kakutani, T.
10.1101/2025.05.26.656066 — genetics — Posted on 2025-05-29
155 Sez6L2 autoimmunity induces cerebellar ataxia in mice
Reyes-Sepulveda, C. J.; Granato, J.; Randolph, J.; Ryan, A. T.; Hobbins, A.; Stout, A.; Li, H.; Hammond, J. W.
10.1101/2025.05.28.656724 — neuroscience — Posted on 2025-05-29
156 The neural processes of illusory occlusion in object recognition
Ramirez-Haro, A.; Moerel, D.; Quek, G. L.; Varlet, M.; Grootswagers, T.
10.1101/2025.05.28.656741 — neuroscience — Posted on 2025-05-29
159 A BRC1-modulated switch in auxin transport accounts for the competition between Arabidopsis axillary buds
Nahas, Z.; Bridgen, A. J.; Loman, T. E.; Dillon, J.; Abley, K.; Cano-Ramirez, D. L.; Ticchiarelli, F.; Seale, M.; Locke, J. C. W.; Leyser, O.
10.1101/2025.05.26.656108 — plant biology — Posted on 2025-05-29
163 Multimodal gene and targeted drug therapy for chronic myelogenous leukemia: Computational target analysis and therapeutic validation
Lugin, M. L.; Lei, W.; Lee, R. T.; Chung, J. Y.; Katritsis, N. M.; Hwang, W.; Fleischman, A. G.; Han, N.; Kwon, Y. J.
10.1101/2025.05.26.656072 — cancer biology — Posted on 2025-05-29
168 Robust Serum Proteomic Signatures of APOE2
Sebastiani, P.; Reed, E.; Chandler, K. B.; Lopez, P.; Lords, H.; Bae, H.; Costello, C. E.; Au, M.; Denn, L.; Li, M.; Xiang, Q.; Noh, H.; Pflieger, L.; Funk, C.; Rappaport, N.; Nygaard, M.; Short, M.; Brent, M.; Monti, S.; Andersen-Toomey, S. L.; Perls, T.
10.1101/2025.05.24.655950 — genetics — Posted on 2025-05-29
170 DNA Divers: volunteer-based eDNA capture for local and global marine biodiversity monitoring
Neave, E. F.; Watson, A.; Cunnington, A.; Maiello, G.; Yates, N.; Parkes, C. J.; Crouch, F.; Catherall, H. J. N.; Shum, P.; Cai, W.; Allemann, R.; Boswarva, K.; Horner, R.; Northway, W.; Bezombes, F.; Bolton, C.; Anderson, B.; Johnson, E.; Meek, S.; Smith, G.; Mariani, S.
10.1101/2025.05.26.656130 — ecology — Posted on 2025-05-29
171 Woody plant encroachment enhances negative interactions in Arctic plant communities over the last 24,000 years
Liu, Y.; Jia, W.; Liu, S.; Lisovski, S.; Stoof-Leichsenring, K. R.; Farkas, L. Z.; Herzschuh, U.
10.1101/2025.05.26.656118 — ecology — Posted on 2025-05-29
173 Correlates of protection against African swine fever virus identified by a systems immunology approach
Lotonin, K.; Brito, F.; Mehinagic, K.; Garcia-Nicolas, O.; Liniger, M.; Donze, N.; Python, S.; Talker, S.; Ploegaert, T.; Ruggli, N.; Benarafa, C.; Summerfield, A.
10.1101/2025.05.25.655978 — immunology — Posted on 2025-05-29
174 Determinants of visual ambiguity resolution
Linde-Domingo, J.; Ortiz-Tudela, J.; Voeller, J.; Hebart, M. N.; Gonzalez-Garcia, C.
10.1101/2025.05.28.656283 — neuroscience — Posted on 2025-05-29
181 Functional characterization of pathogenic SATB2 missense variants identifies distinct effects on chromatin binding and transcriptional activity
den Hoed, J.; Semmekrot, F.; Verseput, J.; Dingemans, A. J.; Schijven, D.; Francks, C.; Zarate, Y. A.; Fisher, S. E.
10.1101/2025.05.28.656698 — genetics — Posted on 2025-05-29
183 KcatNet: A Geometric Deep Learning Framework for Genome-Wide Prediction of Enzyme Catalytic Efficiency
Pan, T.; Cui, X.; Koh, H. Y.; Bi, Y.; Wang, X.; Zhang, Y.; Hu, S.; Webb, G. I.; Kurgan, L.; Zhang, G.; Song, J.
10.1101/2025.03.09.642294 — bioinformatics — Posted on 2025-05-29
185 A nucleic acid prodrug that activates mitochondrial respiration, promotes stress resilience, and prolongs lifespan
Anada, T.; Kawahara, M.; Shimada, T.; Kuroda, R.; Okamura, H.; Setoyama, D.; Nagatsugi, F.; Kunisaki, Y.; Kage-Nakadai, E.; Kobayashi, S.; Tanaka, M.
10.1101/2024.11.16.623599 — bioengineering — Posted on 2025-05-29
186 Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum
Setogawa, S.; Okauchi, T.; Hu, D.; Wada, Y.; Hikishima, K.; Onoe, H.; Nishizawa, K.; Sakayori, N.; Miyawaki, H.; Kitanishi, T.; Mizuseki, K.; Cui, Y.; Kobayashi, K.
10.1101/2023.10.19.563198 — animal behavior and cognition — Posted on 2025-05-29
187 Odorant receptors mediating avoidance of toxic mustard oils in Drosophila melanogaster are expanded in herbivorous relatives
Matsunaga, T.; Reisenman, C. E.; Goldman-Huertas, B. M.; Rajshekar, S.; Suzuki, H. C.; Tadres, D.; Wong, J.; Louis, M.; Ramirez, S. R.; Whiteman, N. K.
10.1101/2024.10.08.617316 — evolutionary biology — Posted on 2025-05-29
190 SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres
Spindler, J.; Pandolfo, F.; Koch, A. E.; Piccirillo, P.; Bihler, J.; Morgenstern, M.; Coon, J.; Haensel-Hertsch, R.; Mehta, K. P. M.; Panier, S.
10.1101/2025.05.28.656696 — cell biology — Posted on 2025-05-29
191 Filopodia numbers impact chemotactic migration speed
Schroder, A. L.; Oster, L. D.; Savich, Y.; Titus, M. A.
10.1101/2025.05.28.656686 — cell biology — Posted on 2025-05-29
192 An expanded palette of bright and photostable organellar Ca2+ sensors
Moret, A.; Farrants, H.; Fan, R.; Zingg, K.; Silva, B.; Roselli, C.; Oertner, T. G.; Gee, C. E.; Hadjieconomou, D.; Rangaraju, V.; Schreiter, E. R.; de Juan-Sanz, J.
10.1101/2025.01.10.632364 — cell biology — Posted on 2025-05-29
193 Enalapril mitigates senescence and aging-related phenotypes by targeting antioxidative genes via phosphorylated Smad1/5/9
Lyu, W.; Wang, H.; Du, Z.; Wei, R.; He, J.; Meng, F.; Bi, J.; Zhang, L.; Zhang, C.; Guan, Y.; Tao, W.
10.1101/2024.11.27.625711 — cell biology — Posted on 2025-05-29
195 Perinatal fluoxetine exposure increases male rat sexual behavior
Baann, A. K.; Houwing, D. J.; Olivier, J. D. A.; Heijkoop, R.; Snoeren, E. M. S.
10.1101/2025.05.26.656113 — neuroscience — Posted on 2025-05-29
197 Decoding the Cognitive map: Learning place cells and remapping
Pettersen, M. B.; Schoyen, V. S.; Malthe-Sorenssen, A.; Lepperod, M. E.
10.1101/2024.03.14.585049 — neuroscience — Posted on 2025-05-29
198 The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.
Calleja, v.; Henry, J. C.; Cobbaut, M.; Sewell, J.; Rizzoti, K.; Houghton, F.; Boeing, S.; Anyanwu, N.; Varsani-Brown, S.; Snoeks, T.; Suarez-Bonnet, A.; Priestnall, S. L.; McDonald, N. Q.; Cameron, A. J.; Parker, P. J.
10.1101/2025.05.28.656646 — cancer biology — Posted on 2025-05-29
200 Chemotaxis of branched cells in complex environments
Liu, J.; Ron, J. E.; Rinaldi, G.; Williantarra, I.; Georgantzoglou, A.; de Vries, I.; Sixt, M.; Sarris, M.; Gov, N.
10.1101/2025.05.27.656457 — biophysics — Posted on 2025-05-29
203 Establishment of Drosophila Intestinal Cell Lines.
Luhur, A.; Mariyappa, D.; Bohall, P.; Multini, L. C.; Elkins, M.; Zelhof, A.
10.1101/2025.05.27.656384 — cell biology — Posted on 2025-05-29
204 Kinesin drive meiotic chromosome dynamics via interaction with the KASH5-LINC complex
Ditamo, Y.; Shi, W.; Previato, L.; Gillies, J. J.; Carbajal, A.; Kinter, M.; DeSantis, M. E.; Bisig, G.; Pezza, R. J.
10.1101/2025.05.28.656678 — cell biology — Posted on 2025-05-29
205 miR-196a-5p and miR-342-3p mediate skeletal muscle and thermogenic adipose tissue crosstalk through extracellular vesicles
Tischer, D.; Schranner, D.; Kallabis, S.; Braunsperger, A.; Schoenfelder, M.; Gnad, T.; Jost, P. J.; Nesic, S.; Renziehausen, F.; Fester, L.; Buness, A.; Hasenauer, J.; Meissner, F.; Pfeifer, A.; Wackerhage, H.; Soriano-Arroquia, A.
10.1101/2025.05.28.656129 — cell biology — Posted on 2025-05-29
207 Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation
Swann, J. W.; Fung, J. H.; Chen, Z.; Olson, O. C.; Collins, A.; Lhakang, T.; Proven, M. A.; Zhang, R.; Rabadan, R.; Passegue, E.
10.1101/2025.05.28.656712 — cell biology — Posted on 2025-05-29
208 Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation
Panek, J.; Sun, C.; Kataura, T.; Fielder, E.; Booth, L.; Yue, W.; Richardson, G.; Reynisson, J.; Korolchuk, V. I.
10.1101/2025.05.27.656309 — cell biology — Posted on 2025-05-29
209 PINK1 SUMOylation regulates basal mitophagy
Ramesh, N. S.; Seager, R.; Wilkinson, K.; Henley, J. M.
10.1101/2025.05.27.656300 — cell biology — Posted on 2025-05-29
213 Temporal and spatial coordination of DNA segregation and cell division in an archaeon.
Parham, J.; Cezanne, A.; Sorichetti, V.; Hoogenberg, B.; Foo, S.; Kuo, Y.-w.; Mawdesley, E.; Gatward, L. D.; Schulze, U.; Boulanger, J.; Saric, A.; Baum, B.
10.1101/2025.05.28.656325 — cell biology — Posted on 2025-05-29
216 VEGF-C-mediated Cardiac Lymphangiogenesis Promotes Inflammation Resolution in Autoimmune Acute Myocarditis in Mice
Nakanishi, N.; Nakamori, S.; Hara, S.; Nagaharu, K.; Matsuyama, R.; Fujita, S.; Okamoto, R.; Dohi, K.; Hiroe, M.; Imanaka-Yoshida, K.; Maruyama, K.
10.1101/2025.05.25.656051 — pathology — Posted on 2025-05-28
217 Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis
Edirisuriya, P.; Liyanage, P.; Lee, J.; Shetty, A. J.; Liu, H.; Hutchings, D.; Freeman, A. J.; Nathan, J. D.; Appakalai, B.; Pandol, S. J.; Jegga, A. G.; Naren, A. P.; Arora, K.
10.1101/2025.05.25.656006 — pathology — Posted on 2025-05-28
219 Temporal dynamics of color polymorphism and hybridization in Colias butterflies
Jahner, J. P.; Forister, M.; Parchman, T.; Burdo, S.; McFarlane, S. E.; Buerkle, C. A.; Nice, C.; Fordyce, J.; Shapiro, A.
10.1101/2025.05.25.656022 — evolutionary biology — Posted on 2025-05-28
222 Spatiotemporal dynamics of CD73 in mouse retina under physiological conditions
Ishii, R.; Sakurai, K.; Hosomi, N.; Fleischmann, B.; Mizuno, S.; Kimura, K.; Yanagisawa, H.
10.1101/2025.05.25.655881 — developmental biology — Posted on 2025-05-28
223 Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression
Ross, C. J.; Sarusi, Y.; Lubelsky, Y.; Perry, R. B.-T.; Mavashov, A.; Turk, S.; Rubinstein, M.; Ulitsky, I.
10.1101/2025.05.28.656657 — molecular biology — Posted on 2025-05-28
224 A safer fluorescent in situ hybridization protocol for cryosections
Chihara, A.; Mizuno, R.; Kagawa, N.; Takayama, A.; Okumura, A.; Suzuki, M.; Shibata, Y.; Mochii, M.; Ohuchi, H.; Sato, K.; Suzuki, K.-i. T.
10.1101/2025.05.25.655994 — molecular biology — Posted on 2025-05-28
226 Macroscale Connectivity in the Octopus brain
Pizzulli, F.; Barjami, M.; Edelman, D. B.; Fiorito, G.; Ponte, G.
10.1101/2025.05.28.656524 — neuroscience — Posted on 2025-05-28
228 SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids
Statoulla, E.; Zafeiri, M.; Chalkiadaki, K.; Voudouri, G.; Gkika, K. S.; Papazoglou, C.; Durcan, T.; Khoutorsky, A.; Jafarnejad, S. M.; Maguire, S.; Dityatev, A.; Gkogkas, C. G.
10.1101/2025.05.28.656641 — neuroscience — Posted on 2025-05-28
229 Vesicular Rps6 released by astrocytes regulate local translation and enhance synaptic markers in neurons
Gamarra, M.; de la Cruz-Gambra, A.; Blanco-Urrejola, M.; Gonzalez, E.; Azkargorta, M.; Elortza, F.; Falcon-Perez, J. M.; Baleriola, J.
10.1101/2025.05.28.656644 — neuroscience — Posted on 2025-05-28
230 Neonatal White Matter Microstructure Predicts Infant Attention Disengagement from Fearful Faces
Audah, H. K.; Pulli, E. P.; Nolvi, S.; Jolly, A.; Rosberg, A.; Luotonen, S.; Wigley, I. L. C. M.; Hashempour, N.; Li, R.; Vartiainen, E.; Suuronen, I.; Haikio, T.; Merisaari, H.; Lewis, J. D.; Korja, R.; Tuulari, J. J.; Karlsson, H.; Karlsson, L.; Kataja, E.-L.
10.1101/2025.05.28.655764 — neuroscience — Posted on 2025-05-28
232 Continuous dynamics of cooperation and competition in social foraging
Lewen, D.; Ivanov, V.; Dehning, J.; Russ, J.; Fischer, A.; Penke, L.; Schacht, A.; Gail, A.; Priesemann, V.; Kagan, I.
10.1101/2025.05.28.655569 — neuroscience — Posted on 2025-05-28
243 Methicillin-Resistant Staphylococcus aureus has Phenotypic Variation in mecA Expression that Alters Antibiotic Sensitivity
Ma, D.; Arya, R.; Knapick, B. A.; Sadaka, N.; Rempuszewski, J.; Moul, C.; Mandell, J. B.; Shah, N. B.; Doub, J. B.; Gish, C.; Parker, D.; Sydlik, S. A.; Wood, H.; Cooper, V. S.; Richardson, A. R.; Shanks, R. M.; Urish, K. L.
10.1101/2025.05.28.656574 — microbiology — Posted on 2025-05-28
244 Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens
Ghoreyshi, Z. S.; Tubo, N.; Zammataro, L.; Mao, X.; Ngai, H.; Wang, D.; Chen, Y.; He, Q.; Cisneros, E.; Liang, S.; Koppikar, P. J.; Lin, X.; Molldrem, J. J.; George, J. T.
10.1101/2025.05.25.655924 — immunology — Posted on 2025-05-28
245 VCAN is essential for ERK5-driven tumorigenesis in soft tissue sarcoma
Jimenez Suarez, J.; Cimas, F. J.; Paricio, J. J.; Belandia, B.; Berrouayel Dahour, Y.; Arconada-Luque, E.; Matilla-Almazan, S.; Soffientini, C.; Percio, S.; Redondo-Garcia, S.; Garcia-Flores, N.; Garnes-Garcia, C.; Fernandez-Aroca, P.; Martinez-Gomez, J. J.; Fernandez-Aramburo, A.; Nam-Cha, S. H.; Rovida, E.; Pandiella, A.; Esparis-Ogando, A.; Pasquali, S.; Rodriguez-Manzaneque, J. C.; Del Peso, l.; Ruiz Hidalgo, M. j.; Sanchez-Prieto, R.
10.1101/2025.05.28.654281 — cancer biology — Posted on 2025-05-28
247 The genomic legacy of selectively breeding rhesus macaques for HIV/AIDS-related research
Lyke, M. M.; Bagwell, A.; Newman, D.; Galindo, S.; Church, T.; Christensen, C.; Gray, S. B.; Cox, L. A.; Ross, C. N.; Kaushal, D.; Cheeseman, I. H.; Cole, S. A.
10.1101/2025.05.26.654976 — genomics — Posted on 2025-05-28
248 Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
Gupta, R.; Durham, T. J.; Chau, G.; Uddin, M. M.; Lu, W.; Karczewski, K. J.; Howrigan, D.; Natarajan, P.; Zhou, W.; Neale, B. M.; Mootha, V. K.
10.1101/2025.05.25.655566 — genetics — Posted on 2025-05-28
249 Rapid adaptation and extinction across climates in synchronized outdoor evolution experiments of Arabidopsis thaliana
Wu, X.; Bellagio, T.; Peng, Y.; Czech, L.; Lin, M.; Lang, P.; Epstein, R.; Abdelaziz, M.; Alexander, J.; Caton-Darby, M.; Alonso-Blanco, C.; Andersen, H. L.; Berbel, M.; Bergelson, J.; Burghardt, L.; Delker, C.; Dimitrakopoulos, P. G.; Donohue, K.; Durka, W.; Escribano-Avila, G.; Franks, S. J.; Fritschi, F. B.; Galanidis, A.; Garcia-Fernandez, A.; Garcia-Munoz, A.; Hamann, E.; Herber, M.; Hutt, A.; Iriondo, J. M.; Juenger, T. E.; Keller, S.; Koehl, K.; Korte, A.; Korte, P.; Kuschera, A.; Lara-Romero, C.; Leventhal, L.; Maag, D.; Marcer, A.; March-Salas, M.; Meaux, J. d.; Mendez-Vigo, B.; Moren
10.1101/2025.05.28.654549 — evolutionary biology — Posted on 2025-05-28
253 Proton motive force as a driver of persister sensitization by adenosine
Thompson, N. T.; Kitzenberg, D. A.; Dowdell, A. S.; Roer, R. L.; Lee, J. S.; Worledge, C. S.; Colgan, S. P.; Kao, D. J.
10.1101/2025.05.28.655832 — microbiology — Posted on 2025-05-28
254 Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reduce Pseudomonas- biofilm formation and inflammation in CF Bronchial Epithelial Cells
Sarkar, S.; Barnaby, R.; Nymon, A.; Charpentier, L. A.; Taub, L.; Wargo, M. J.; Weiss, D. J.; Bonfield, T. L.; Stanton, B. A.
10.1101/2025.05.28.656674 — microbiology — Posted on 2025-05-28
256 Nutrient requirements for cell differentiation progression in Batrachochytrium dendrobatidis
Okada, N. C.; Williams-Carter, T.; Contreras, J.; Hill, T.; O'Brien, D.; Abel-Santos, E.
10.1101/2025.05.28.656562 — microbiology — Posted on 2025-05-28
262 Microbial community composition explains wintertime greenhouse gas fluxes in an oroarctic tundra ecosystem
Viitamäki, S.; Eronen-Rasimus, E.; Virkkala, A.-M.; Marushchak, M.; Biasi, C.; Majamäki, R.; Pessi, I. S.; Hultman, J.
10.1101/2025.05.28.656102 — microbiology — Posted on 2025-05-28
264 Kasugamycin inhibits melanoma lung metastasis and regulates CHI3L1-driven M2-like tumor-associated macrophage differentiation
Sadanaga, T.; Jeong, H.-S.; Cortez, R.; Lee, J. H.; Kamle, S.; Ma, B.; Shin, S. J.; Elias, J. A.; Lee, C. G.
10.1101/2025.05.26.654629 — immunology — Posted on 2025-05-28
265 Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks
Watanabe, K.; Yamamoto, H.; Sumi, T.; Murota, H.; Osaki, H.; Kawamoto, K.; Matsui, T.; Masamizu, Y.; Sato, S.; Hirano-Iwata, A.
10.1101/2025.05.25.654991 — neuroscience — Posted on 2025-05-28
269 Characterization of recombinase-based genetic parts and circuits using nanopore sequencing
Greco, F. V.; Cameron, S. K.; Joshi, S. H.-N.; Guiziou, S.; Brophy, J. A. N.; Grierson, C. S.; Gorochowski, T. E.
10.1101/2025.05.27.656450 — synthetic biology — Posted on 2025-05-28
270 Developing a versatile technology for agroinfiltration in multiple plants
Du, H.; Wang, T.; Ge, J.; Qu, C.; Chen, H.; Li, J.; Wang, S.; Guan, X.; Chen, T.; Si, Z.; Hu, K.; Ding, X.; Liu, L.; Zhang, J.; Mishin, A. S.; Yampolsky, I. V.
10.1101/2025.05.25.656011 — plant biology — Posted on 2025-05-28
271 A non-rectifying potassium channel increases cassava drought tolerance and storage root yield
Zierer, W.; Fritzler, M.; Chiu, T. J.; Anjanappa, R. B.; Chang, S.-H.; Metzner, R.; Quiros, J.; Lamm, C. E.; Thieme, M.; Koller, R.; Huber, G.; Muller, O.; Rascher, U.; Sonnewald, U.; Neuhaus, H. E.; Gruissem, W.; Bellin, L.
10.1101/2025.05.26.655271 — plant biology — Posted on 2025-05-28
273 Multiple FGFR1 mutations modulate tumorigenic mechanisms in glioneuronal tumors.
Boni, J.; Fernandez-Gonzalez, M.; Han, H.; Roca, C.; Wong, C. J.; Rioja, C.; Nogue, C.; Manen-Freixa, L.; Boulais, J.; Torres-Urtizberea, E.; Gomez, A.; Hasselblatt, M.; Estrada-Tejedor, R.; Antolin, A. A.; Elkholi, I. E.; Jabado, N.; Cote, J.-F.; Gingras, A.-C.; Rivera, B.
10.1101/2025.05.27.654799 — cancer biology — Posted on 2025-05-28
274 The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer
Gladstein, A. C.; Poltorack, C. D.; Solomon, A. M. C.; Venkatesh, S.; Adler, K. M.; Robertson, M. R.; Stransky, S.; Irizarry-Negron, V. M.; Ruiz, D. A.; Freeburg, N. F.; Sidoli, S.; Asangani, I. A.; Shaffer, S. M.; Feldser, D. M.
10.1101/2025.05.25.655971 — cancer biology — Posted on 2025-05-28
278 Ketone Bodies-mediated Cysteine Modifications Discovered by Chemical Proteomics
Zhou, Y.-F.; Zhang, L.; Niu, Z. L.; WANG, X.; Hunt, R.; Zhao, Y.; Sharifi, N.; Wang, Z. A.
10.1101/2025.05.25.655943 — biochemistry — Posted on 2025-05-28
280 Local adaptation in climate tolerance at a small geographic scale contrasts with broad latitudinal patterns
Walter, G. M.; Chakraborty, A.; Cockerell, F.; Kellermann, V.; Alton, L. A.; White, C. R.; Hall, M. D.; Sgro, C. M.
10.1101/2025.05.27.655235 — evolutionary biology — Posted on 2025-05-28
281 Multi-stage single-cell atlas of Botryllus schlosseri asexual development unveils dedifferentiating bud founder cells
Lebel, M.; Sancerini, T.; Rabiteau, S.; Marchal, S.; Sharma, P.; Scully, T. D.; Balissat, E.; Hiebert, L. S.; De Tomaso, A. W.; Klein, A. M.; Alie, A.; Tiozzo, S.
10.1101/2025.05.27.655565 — developmental biology — Posted on 2025-05-28
283 Aptamer-Enabled Discovery and Clinical Analysis of Exosomal Surface Biomarkers in Hepatocellular Carcinoma
Cao, H.; Xu, D.; Su, Y.; Zhang, C.; Bian, S.; Yan, X.; Li, S.; Xuan, H.; Long, J.; Yao, P.; Liu, X.; Cheng, X.; Su, H.; Chen, Y.; Li, Y.; Li, J.; Shi, W.; Wang, K.; Xing, B.; Zhang, L.
10.1101/2025.05.28.655095 — molecular biology — Posted on 2025-05-28
284 Human genetic variation shapes the response of neurons to interferons
Andzelm, M. M.; Bolshakova, S.; Pettinari, N.; Tegtmeyer, M.; Meyer, D.; Johnson, A.; Mello, C. J.; Yu, C. T.; Mazureac, I.; Genovese, G.; Maglieri, A.; Ichihara, K.; Hogan, M.; Hawes, D.; McCarroll, S. A.; Nehme, R.
10.1101/2025.05.28.653507 — molecular biology — Posted on 2025-05-28
286 Genome-Wide Interrogation of SARS-CoV-2 RNA-Protein Interactions Uncovers Hidden Regulatory Sites
Xiang, J. S.; Zhao, K. X.; Tadri, L.; Tamaru, K.; Yee, B. A.; Rothamel, K.; Schmok, J. C.; Mueller, J. R.; Park, S. S.; Madrigal, A. A.; McVicar, R. N.; Kwong, E. M.; Croker, B. A.; Clark, A. E.; Carlin, A. F.; Acevedo, C.; McCole, D. F.; O'Leary, S. E.; Hai, R.; Leibel, S. L.; Yeo, G. W.
10.1101/2025.05.26.656146 — molecular biology — Posted on 2025-05-28
287 FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis
Sasaki, M.; Wang, J.; Zhou, Y.; Kennedy, Z. V.; Teranishi, R.; Itami, T.; Ishikawa, S.; Winters, H. E.; Hara, T.; McMillan, E.; Mahon, M.; Golden, H.; Dhakal, D.; Bacarella, A.; Umeweni, C.; Wilkins, B. J.; Karakasheva, T. K.; Whelan, K. A.; Shaffer, S. M.; Ruffner, M. A.; Muir, A.
10.1101/2025.05.25.655133 — molecular biology — Posted on 2025-05-28
288 Structural modelling and dynamics of the full-length Homer1 multimer
Kalman, Z. E.; Czajlik, A.; Maruzs, B.; Farkas, F.; Pap, I.; Homonnay, C.; Klumpler, T.; Batta, G.; Gaspari, Z.; Peterfia, B.
10.1101/2025.05.26.655084 — molecular biology — Posted on 2025-05-28
290 Design of a Streptolysin O Epitope-Centric Nanoparticle Vaccine Against Streptococcus pyogenes
Tang, D.; Chao, Y.; Hjortswang, E.; Ströbaek, J.; Hultgren, L.; Mohanty, T.; Karlsson, C.; Ekström, S.; Happonen, L.; Shannon, O.; Malmström, L.; Malmström, J.
10.1101/2025.05.25.655993 — immunology — Posted on 2025-05-28
291 MitoTracker transfers from astrocytes to neurons independently of mitochondria
Hole, K. L.; Norkett, R.; Russell, E.; Strom, M.; Howden, J. H.; Corbett, N. J.; Brownlees, J.; Devine, M. J.
10.1101/2025.05.27.655523 — neuroscience — Posted on 2025-05-28
293 FMO and CYP monooxygenase families determine the metabolic flux of hydroxylated tryptamine derivatives in barley (Hordum vulgare) following pathogen infection
Christensen, J. M.; Toldam-Andersen, M. M.; Jorgensen, H. J.; Micic, N.; Bjarnholt, N.; Vijayanathan, M.; Motawie, M. S.; Pizaine, M.; Günther, J.; Kjaerulff, L.; Staerk, D.; Burow, M.; Thodberg, S.; Neilson, E. H.
10.1101/2025.05.25.656007 — plant biology — Posted on 2025-05-28
294 Repurposing statins in combination therapy for effective ablation of metastatic breast cancer
Aara, R.; Sinai Borker, N.; Sajimon, J.; Subhadarshini, S.; VP, S.; Nimbalkar, V.; Moorthy, M.; P Thankamony, A.; Krishnan R, A.; Aich, D.; Das, D.; Jolly, M. K.; Prabhu, J. S.; Nair, R.
10.1101/2025.05.25.655937 — cancer biology — Posted on 2025-05-28
299 Engineered collagen-coated scaffolds for tendon regeneration: a multifunctional drug delivery approach
Di Marco, C.; Romano, F.; Lopresti, F.; Campora, S.; Comelli, A.; Di Gesu, R.; La Carrubba, V.
10.1101/2025.05.25.655996 — bioengineering — Posted on 2025-05-28
300 Human Skin Model from 15 GHz to 110 GHz
Christ, A.; Aeschbacher, A.; Tarigan, B.; Chitnis, N.; Fallahi, A.; Kuehn, S.; Capstick, M.; Kuster, N.
10.1101/2025.05.26.652827 — bioengineering — Posted on 2025-05-28
302 TIP-seq: A Single-cell Multiomics Approach for Simultaneous Transcriptome and Intracellular Protein Profiling
Xue, Y.; Qi, J.; Xie, G.; Wang, M.; Xu, W.; Ma, C.; Xu, X.; Yang, Y.; He, Y.; Guo, Y.; Chen, S.; Chen, Z.; Qiu, M.; Feng, C.; Liu, J.; Wu, H.; Liu, Y.; Xu, T.; Cao, X.
10.1101/2025.05.26.653374 — biochemistry — Posted on 2025-05-28
307 Hair cell population integrity necessary to preserve vestibular function
Schenberg, L.; Simon, F.; Palou, A.; Dijan, C.; Tagliabue, M.; Llorens, J.; Beraneck, M.
10.1101/2025.03.19.644154 — neuroscience — Posted on 2025-05-28
311 Helfrich Monte Carlo Flexible Fitting: physics-based, data-driven cell-scale simulations
Maurer, V. J.; Siggel, M.; Jensen, R. K.; Mahamid, J.; Kosinski, J.; Pezeshkian, W.
10.1101/2025.05.24.655915 — biophysics — Posted on 2025-05-28
315 Intervertebral disc impairments in a mouse model of Alzheimer's Disease
Gonzalez, C. C.; Schurman, C. A.; Wilson, K. A.; Schilling, B.; Ellerby, L. M.; Tang, S. Y.
10.1101/2025.05.24.655931 — bioengineering — Posted on 2025-05-28
316 PEDOT:PSS Microparticles for Extrudable and Bioencapsulating Conducting Granular Hydrogel Bioelectronics
Goestenkors, A. P.; Yu, J. S.; Park, J.; Wu, Y.; Espinoza, C. J. V.; Friedman, L. C.; Okafor, S. S.; Liu, T.; Chatterjee, S.; Debnath, A.; Semar, B. A.; O'Hare, C. P.; Alvarez, R. M.; Singamaneni, S.; Raman, B.; Rutz, A. L.
10.1101/2025.05.25.655149 — bioengineering — Posted on 2025-05-28
320 Proximity and current alignment drives fertilisation success in a broadcast-spawning coral
Ricardo, G. F.; Doropoulos, C.; Humanes, A.; Lachs, L.; Martinez, H. M.; Sartori, G.; Chang, T. K. T.; Chui, A. P. Y.; Wong, E. L. C.; Stevens, J. R.; Popovic, I.; Guest, J. R.; Buccheri, E.; Idip, D.; Mumby, P. J.
10.1101/2025.05.24.654664 — ecology — Posted on 2025-05-28
321 Reconstitution of adrenocortical functional zonation from human pluripotent stem cells
Mayama, M.; Whelan, E. C.; Sato, T.; Stouffer, D. G.; Leu, N. A.; Strauss, J. F.; Auchus, R.; Sasaki, K.
10.1101/2025.05.24.655925 — developmental biology — Posted on 2025-05-28
322 Adaptive-like NK cell responses to influenza correlate with humoral immunity and are influenced by age and sex
Alves, E.; Oakes, J. M.; Simmons, J. D.; Currenti, J.; Coudert, J. D.; Foley, B.; Eason, J.; Halasa, N. B.; Talbot, H. K.; Castilho, J. L.; Mallal, S.; Gaudieri, S.; Kalams, S. A.
10.1101/2025.05.24.655902 — immunology — Posted on 2025-05-28
324 Unbiased Quantification of Persistent Postural and Motor Deficits Following Spinal Cord Injury in Mice
Jobbins, S. S.; Pande, V.; Zeng, C.-W.; Poldsam, H.; Pool, A.-H.; Zhang, C.-L.; Lai, H. C.
10.1101/2025.05.24.655880 — neuroscience — Posted on 2025-05-28
325 The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
Marinescu, A.-M.; Kamal, E.; Leary, P.; Navarro I Batista, K.; Klug, M.; Savic, N.; Le Foll, C.; Labouesse, M. A.
10.1101/2025.05.24.655907 — neuroscience — Posted on 2025-05-28
326 Evaluation of visual performance for RCS rats: A tailor-made OMR setup via DeepLabCut and PsychoPy with a customized algorithm
Wang, J.; Rueland, T.; Krause, S.; Schoeneck, M.; Shah, N. J.; Mueller, F.; Kampa, B.; Langen, K.-J.; Willuweit, A.
10.1101/2025.05.24.655932 — neuroscience — Posted on 2025-05-28
330 Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease
Shi, L.; Uzuni, A.; Wang, X. K.; Pressler, M.; Harle, D. W.; Chakrabarti, S.; Macedo, R.; Belay, K.; Gordillo, C. A.; Raps, E.; Zhang, J. Y. A.; Nazaret, A.; Fan, J. L.; Jin, Y.; Shen, X.; Fuller, J. S.; Azad, T.; Huang, J.; Chainani, P.; Abrams, J. A.; Del Portillo, A.; Mapara, M. Y.; Alhamar, M.; Sykes, M.; McFaline-Figueroa, J.; Azizi, E.; Reshef, R.
10.1101/2025.05.24.655962 — systems biology — Posted on 2025-05-28
331 Under salt stress quinoa stomatal guard cells control transpiration in an ABA-primed manner
Huang, S.; Messerer, M.; Muller, H. M.; Scherzer, S.; Roelfsema, M. R. G.; Weiste, C.; Krischke, M.; Korte, P.; Moog, M. W.; Mayer, K. F. X.; Ache, P.; Hedrich, R.
10.1101/2025.05.24.655927 — plant biology — Posted on 2025-05-28
332 Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesisvia Substrate Channeling
Wang, D.; Gottinger, A.; Jeong, J.; Nicoll, C. R.; Liu, J.; Kadav, T.; Cecchini, D.; Malatesta, M.; Heck, A. J. R.; Mattevi, A.; Shakhnovich, E.
10.1101/2025.05.24.655883 — biophysics — Posted on 2025-05-28
334 Acoustic individual identification in a species of field cricket using deep learning
Kabuga, E.; Nandi, D.; Burrell, S.; Dlamini, G.; Balakrishnan, R.; Bah, B.; Durbach, I.
10.1101/2025.05.24.655958 — bioinformatics — Posted on 2025-05-28
337 Characterizing antibodies binding to the same epitope reveals limited contribution by heavy chain CDR3 sequences relative to other CDRs
Mahita, J.; Kim, H.; De Almeida Mendes, M.; Richardson, E.; Greenbaum, J. A.; Sette, A.; Nielsen, M.; Peters, B.
10.1101/2025.05.24.655967 — bioinformatics — Posted on 2025-05-28
339 Development of Second-Generation Acyl Silane Photoaffinity Probes for Cellular Chemoproteomic Profiling
Page, A. C. S.; Orr, L. M.; Meyers, M. L.; Belcher, B. P.; Coffey, T. G.; Scholz, S. O.; Cismoski, S.; Nomura, D.; Toste, F. D.
10.1101/2025.05.24.655972 — biochemistry — Posted on 2025-05-28
342 Global metabolic reprogramming and sex-specific impact of caloric restriction in a mouse model of Alzheimer's disease
Vatashchuk, M. V.; Hurza, V. V.; Bayliak, M. M.; Gospodaryov, D. V.; Lushchak, V. I.; Garaschuk, O.
10.1101/2025.05.24.655912 — neuroscience — Posted on 2025-05-28
347 Extracellular Matrix Alterations in Chronic Ischemic Cardiomyopathy Revealed by Quantitative Proteomics
Buck, K. M.; Rogers, H. T.; Gregorich, Z. R.; Mann, M. W.; Aballo, T. J.; Gao, Z.; Chapman, E. A.; Perciaccante, A. J.; Price, S. J.; Lei, I.; Tang, P. C.; Ge, Y.
10.1101/2025.05.23.655833 — biochemistry — Posted on 2025-05-28
348 Drought reduces formation, but enhances persistence, of mineral-associated organic matter in a grassland soil
Sokol, N.; Foley, M.; Blazewicz, S. J.; Didonato, N.; Estera-Molina, K.; Firestone, M. K.; Greenlon, A.; Hungate, B. A.; Kew, W.; Pasa-Tolic, L.; Slessarev, E.; Pett-Ridge, J.
10.1101/2025.05.23.655838 — ecology — Posted on 2025-05-28
349 Computational characterization of metacognitive ability in subjective decision-making
Plate, C. R.; Govil, D.; Zheng, C. Y.; Boundy-Singer, Z. M.; Ziemba, C. M.; Lopez-Guzman, S.
10.1101/2025.05.23.655775 — neuroscience — Posted on 2025-05-28
353 A Cellular Basis for Heightened Gut Sensitivity in Females
Venkataraman, A.; Figueroa, E. E.; Castro, J.; Navarro, F. M. C.; Soota, D.; Brierley, S. M.; Julius, D.; Ingraham, H. A.
10.1101/2025.05.23.654927 — physiology — Posted on 2025-05-28
356 Population-specific bycatch risks in two vulnerable anadromous clupeids: insights from otolith microchemistry
Nachon, D. J.; Pico-Calvo, A.; Daverat, F.; Vieira-Lanero, R.; Crujeiras, R. M.; Belo, A. F.; Mateus, C. S.; Quintella, B.; Almeida, P. R.; Antunes, C.; Bareille, G.; Pecheyran, C.; Claverie, F.; Lambert, P.; Lasalle, G.; Cobo, F.
10.1101/2025.05.23.655712 — ecology — Posted on 2025-05-28
358 Longitudinal Habituation and Novelty Detection neural responses from infancy to early childhood in The Gambia and UK
Blasi Ribera, A.; Blanco Maniega, B.; McCann, S.; Mbye, E.; Touray, E.; Rozhko, M.; Milosavljevic, B.; Katus, L.; Saidykhand, M.; Ceesay, M.; Fadera, T.; Ghillia, G.; Perapoch Amado, M.; Moore, S. E.; Elwell, C. E.; Lloyd-Fox, S.
10.1101/2025.05.23.655801 — neuroscience — Posted on 2025-05-28
360 A novel frameshift mutation in Phosphoinositide 3-kinase regulatory subunit 1 (PIK3R1) causes immunodeficiency and Amyotrophic Lateral Sclerosis (ALS)
Calco, B.; Sweeney, C. L.; Steiner, J.; Wang, T.; Markowitz, T. E.; Paul, S.; Palicha, B.; Dinges, S. S.; Yoo, K.; Henderson, L.; Mcdonald, V.; De Ravin, S. S.; Greenberg, B.; Zerbe, C.; Notarangelo, L. D.; Holland, S. M.; Nath, A.; Safavi, F.
10.1101/2025.05.23.655625 — neuroscience — Posted on 2025-05-28
362 Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment
Chong, D. J. W.; Albulescu, L.-O.; Westhorpe, A. R.; Clare, R. H.; Marriott, A. E.; Woodley, C. M.; Gunasekar, R.; Mosallam, N.; Crittenden, E.; Stars, E.; Dawson, C. A.; Kool, J.; Wilkinson, M. C.; Leung, S. C.; Berry, N. G.; Casewell, N. R.; O.Neill, P. M.
10.1101/2025.05.23.655830 — pharmacology and toxicology — Posted on 2025-05-28
364 Replication stress alters CENP-A nucleosome stability during S phase
Lee, A. S.; Huang, C.-F.; Su, T.; Bodner, J.; Kelleher, N. L.; Foltz, D. R.
10.1101/2025.05.23.655122 — biochemistry — Posted on 2025-05-28
366 Evolution of resistance breaking in spinach downy mildew revealed through pangenome graph analysis
Skiadas, P.; Mendel, M.; Elberse, J.; Van den Ackerveken, G.; de Jonge, R.; Seidl, M. F.
10.1101/2025.05.23.655769 — genomics — Posted on 2025-05-28
372 Reciprocal Regulation Between the SCFFBXO24 Ubiquitin E3 Ligase and FoxP1 Protein
Maloy, A.; Walter, S.; Mascilli, A.; Klein, D.; Lardo, S.; Londino, J.; Nyunoya, T.; McDyer, J.; Mai, S.; Zeng, X.; Yates, N.; Cantrell, P.; Hainer, S.; Mallampalli, R.; Chandra, D.
10.1101/2025.05.23.653845 — molecular biology — Posted on 2025-05-28
373 Effects of C3aR activated mast cells in eosinophilic esophagitis
Zhang, S.; Cavallaro, D.; Xia, M.; Ben-Baruch Morgenstern, N.; Shoda, T.; Osswald, G. A.; Bolton, S.; Mukkada, V.; Dunn, J.; Felton, J.; Rochman, M.; Caldwell, J. M.; Derakhshan, T. M.; Rothenberg, M.
10.1101/2025.05.23.655738 — immunology — Posted on 2025-05-28
374 Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Li, T.; Lu, L.; Qiu, J.; Dong, X.; Yang, L.; He, K.; Gu, Y.; Zhou, B.; Jia, T.; Lawrence, T.; Malissen, M.; Wang, G.; Huang, R.; Wang, H.; Malissen, B.; Liang, Y.; Zhang, L.
10.1101/2025.05.23.655779 — immunology — Posted on 2025-05-28
376 Optimized Theta Burst Stimulation with Extended Intervals Enhances Excitatory-Inhibitory Balance
Salimi, M.; Nazari, M.; Mishler, J.; Rodger, J.; Jomehpour, S.; Mishra, J.; Ramanathan, D.
10.1101/2024.08.19.608693 — neuroscience — Posted on 2025-05-28
378 Pathogenic variants in autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation
Singh, K.; Dafsari, H. S.; Gillham, O.; Chi, H.; Mandzhukova, I.; Kourouzidou, I.; Sheshadri, P.; Chung, C.-Y.; Pingitore, V.; Vansenne, F.; Selwood, D. L.; Pendin, D.; Szabadkai, G.; Fanto, M.; Jungbluth, H.; Duchen, M. R.
10.1101/2025.05.23.655806 — neuroscience — Posted on 2025-05-28
380 Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimers disease reveals differences dependent on genotype and sex
Ladurner, G.; Merkle, C. W.; May, L.; Worm, S.; Patel, Y.; Varaka, M.; Daurer, M.; Jauk, L.; Rabl, R.; Koenigshofer, P.; Garhoefer, G.; Prokesch, M.; Baumann, B.
10.1101/2025.05.23.655771 — neuroscience — Posted on 2025-05-28
385 Phenylketonuria: modelling cerebral amino acid and neurotransmitter metabolism
Wegrzyn, A. B.; van Vliet, D.; van Eunen, K.; Heiner-Fokkema, M. R.; van der Zee, E. A.; van Spronsen, F.; Bakker, B. M.
10.1101/2024.01.05.574352 — systems biology — Posted on 2025-05-28
387 High burden of premature ventricular contractions upregulates transcriptional markers of inflammation and promotes adverse cardiac remodeling linked to cardiomyopathy
Medina-Contreras, J. L.; Balderas-Villalobos, J.; Gomez-Arroyo, J.; Hayles, J.; Kaszala, K.; Tan, A. Y.; Samso, M.; Huizar, J. F.; Eltit, J. M.
10.1101/2025.05.23.652709 — physiology — Posted on 2025-05-28
388 Prolonged fasting and glucocorticoid exposure drive dynamic DNA methylation in elephant seals
Gibson, E. F.; Torres-Velarde, J. M.; Ensminger, D. C.; Moreno-Santillan, D. D.; Crocker, D. E.; Vazquez-Medina, J. P.
10.1101/2025.05.23.654932 — physiology — Posted on 2025-05-28
390 Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia
Datar, G. K.; Khabusheva, E.; Anand, A.; Beale, J.; Sadek, M.; Chen, C.-W.; Potolitsyna, E.; Alcantara-Contessoto, N.; Liu, G.; De La Fuente, J.; Dollinger, C.; Guzman, A.; Martell, A.; Wohlan, K.; Maiti, A.; Short, N. J.; Yi, S. S.; Andresen, V. K.; Gjertsen, B. T.; Falini, B.; Rau, R. E.; Brunetti, L.; Sahni, N.; Goodell, M. A.; Riback, J. A.
10.1101/2025.05.23.655671 — biophysics — Posted on 2025-05-28
392 Sequencing the gaps: dark genomic regions persist in CHM13 despite long-read advances
Wadsworth, M. E.; Page, M. L.; Aguzzoli Heberle, B.; Miller, J. B.; Steely, C.; Ebbert, M. T. W.
10.1101/2025.05.23.655776 — bioinformatics — Posted on 2025-05-28
394 A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis
Schaart, J. M.; Wasserberg, D.; Eufrasio Cruz, M. A.; Kea-te Lindert, M.; Van der Meijden, R. H. M.; Roverts, R.; Debera, N. D.; Lu, M. P.; Rouwkema, J.; Nijhuis, W. H.; van der Meer, A. D.; Jonkheijm, P.; Sommerdijk, N.; Akiva, A.
10.1101/2024.07.31.605958 — bioengineering — Posted on 2025-05-28
395 A Modular Microfluidic System to Generate Gradient Hydrogels with Simple-to-Complex Stiffness Profiles for Mechanobiology
Chong, S. W.; Sardharwalla, J.; Masonsong, G. S. P.; Cosgrove, J.; Katselas, A.; Gresham, I. J.; Bilek, M. M.; Shen, Y.; Neto, C.; Vigolo, D.
10.1101/2025.05.23.655778 — bioengineering — Posted on 2025-05-28
399 COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID
DeLine-Caballero, S.; Ratnasiri, K.; Chen, H.; Sahagun, S. J.; Mangalanathan, U. M.; Barnard, T. R.; Turk, N.; Yang, J.; Saini, N.; Ayhan, E. M.; Memetimin, H.; Finlin, B. S.; Licht, Z.; Kern, P. A.; Emery, I.; Leeman, B.; Edelstein, G. E.; Costa, S.; Choi, A.; Licht, J. Z.; Rosen, C.; McLaughlin, T.; Blish, C. A.
10.1101/2025.05.23.655815 — immunology — Posted on 2025-05-28
401 Individual Alpha Frequency Predicts the Sensitivity of Time Perception
Morrow, A.; Wilson, M.; Geller-Montague, M.; Soldano, S.; Hajidamji, S.; Samaha, J.
10.1101/2024.12.16.628734 — neuroscience — Posted on 2025-05-28
403 FAIMS-GPF XL-MS: crosslinking-mass spectrometry based on gas-phase fractionation
Gizardin-Fredon, H.; Terrosu, S.; Pichard, S.; Korkut, D.; Braun, C.; Poterszman, A.; Charenton, C.; Cianferani, S.
10.1101/2025.05.23.655748 — systems biology — Posted on 2025-05-28
404 TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation
Tamada, K.; Tomisawa, E.; Kuwata, S.; Miyake, T.; Nagayasu, K.; Kaneko, S.; Shibasaki, K.; Shirakawa, H.
10.1101/2025.05.23.655698 — pharmacology and toxicology — Posted on 2025-05-28
405 Modeling neural coding in the auditory midbrain with high resolution and accuracy
Drakopoulos, F.; Pellatt, L.; Sabesan, S.; Xia, Y.; Fragner, A.; Lesica, N. A.
10.1101/2024.06.17.599294 — bioengineering — Posted on 2025-05-28
406 Radical Footprinting in Mammalian Whole Blood
Zhao, M.; Tobin, L.; Misra, S. K.; Sharma, A.; Locklar, J.; Shami, A.; Mobarak, S.; Liu, H.; Jones, L. M.; Stewart, J. A.; Sharp, J. S.
10.1101/2024.09.29.615683 — biochemistry — Posted on 2025-05-28
407 Nickel binding to c-Src SH3 domain facilitates crystallization
Calicdan, X.; Fisher, O. S.; Ha, B. H.; Boggon, T. J.; Stiegler, A. L.
10.1101/2025.05.08.652639 — biochemistry — Posted on 2025-05-28
410 A glycan atlas of the mammalian intestine through ontogeny and inflammation
Siegel, S. J.; Pomerantz, D.; Heimburg-Molinaro, J.; Mahmood, S. D.; Korzenik, J. R.; Cummings, R. D.; Rakoff-Nahoum, S.
10.1101/2025.03.06.641959 — microbiology — Posted on 2025-05-28
412 Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation
Wang, J.; Nishiyama, J.; Parra-Bueno, P.; Okaz, E.; Oz, G.; Liu, X.; Watabe, T.; Suponitsky-Kroyter, I.; McGraw, T. E.; Szatmari, E. M.; Yasuda, R.
10.1101/2022.05.17.492345 — neuroscience — Posted on 2025-05-28
413 VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution
Dang, V.; Voigt, B.; Yang, D.; Hoogerbrugge, G.; Lee, M.; Cox, R.; Papoulas, O.; McWhite, C. D.; Pradeep, R.; Leggere, J. C.; Gray, R. S.; Marcotte, E. M.
10.1101/2025.05.26.656196 — systems biology — Posted on 2025-05-28
414 The Single-cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors
Hawkins, A. G.; Shapiro, J. A.; Spielman, S. J.; Mejia, D. S.; Venkatesh Prasad, D.; Ichihara, N.; Yakovets, A.; Gottlieb, A. M.; Wheeler, K. G.; Bethell, C. J.; Foltz, S. M.; O'Malley, J.; Greene, C. S.; Taroni, J. N.
10.1101/2024.04.19.590243 — bioinformatics — Posted on 2025-05-28
415 Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain
Kong, D.; He, H.; Lechner, J.; Yang, J.; Zhang, A.; li, L.; Mathur, R.; Darland, D.; Takaku, M.; Lu, L.; Peng, J.; Yang, K.; Wang, X.
10.1101/2025.05.01.651759 — bioinformatics — Posted on 2025-05-28
418 Groundwater and phenology data reveal vulnerability of riparian trees to drought
Mohammadi, R. M.; Dawson, T. E.; Tiedeman, C. R.; Stella, J.; Ruhi, A.
10.1101/2025.05.23.654357 — ecology — Posted on 2025-05-28
420 Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read Nanopore sequencing
Pastore, S.; Wacheul, L.; Lehmann, L.; Muendnich, S.; Lutz, B.; Helm, M.; Gerber, S.; Lafontaine, D. L.; Butto, T.
10.1101/2025.03.01.640970 — cell biology — Posted on 2025-05-28
421 Transposable Element Derepression-mediated IFN-I Signaling Enhances Stem/Progenitor Cell Activity After Irradiation
Cinat, D.; van der Wal, R.; Baanstra, M.; Gamez, A. A. S.; Jellema-de Bruin, A.; Brouwer, U.; van Goethem, M.-J.; van Vugt, M.; Barazzuol, L.; Coppes, R. P.
10.1101/2024.02.14.580306 — cell biology — Posted on 2025-05-28
422 DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation
Koo, A. S.-H.; Jia, W.; Kim, S. H.; Scalf, M.; Boos, C. E.; Chen, Y.; Wang, D.; Voter, A. F.; Bajaj, A.; Smith, L. M.; Keck, J. L.; Bakkenist, C. J.; Guo, L.; Tibbetts, R. S.
10.1101/2024.10.29.619708 — molecular biology — Posted on 2025-05-28
423 NEUROGLIAL CB1 RECEPTORS CONTROL NAVIGATION STRATEGIES
Egana-Huguet, J.; Sangroniz-Beltran, L.; Baraibar, A. M.; Reyes-Velasquez, P.; Landgraf, N.; Torres-Maldonado, P.; Rodriguez-Cedres, C.; Julio-Kalajzic, F.; Piriz, J.; Ramos-Uriarte, A.; Grandes, P.; Marsicano, G.; Mato, S.; Ceprian, M.; Soria-Gomez, E.
10.1101/2025.05.27.656352 — neuroscience — Posted on 2025-05-28
425 Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling
Ahuja, K.; Ramezankhani, R.; Wang, X.; Burg, T.; Amos, G.; Neyrinck, K.; Silva, A.; Arekatla, G.; Cassidy, E. E.; Nami, F.; Terryn, J.; Wierda, K.; Vints, K.; Vandamme, N.; Poovathingal, S.; Lambrichts, I.; Swinnen, J. V.; Van Den Bosch, L.; De Groef, L.; Moons, L.; Verfaillie, C.; Neyts, J.; Jochmans, D.; Chai, Y. C.
10.1101/2025.05.28.656435 — neuroscience — Posted on 2025-05-28
426 MegaTrack: a framework for the anatomically accurate and time-efficient virtual dissection and analysis of large-scale tractography datasets
Dell'Acqua, F.; Beyh, A.; Stones, R.; Barrett, R. L.; De Santiago Requejo, F.; Laguna, P. L.; Lacerda, L. M.; Davison, C.; Leslie, A.; Howells, H.; Goldstein, L. H.; Williams, S. C.; Catani, M.
10.1101/2025.05.27.656234 — neuroscience — Posted on 2025-05-28
429 Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization
Terceros, A.; Chen, C.; Harada, Y.; Eilers, T.; Gebremedhin, M.; Koche, R. P.; Hamard, P.-J.; Sharma, R.; Rajasethupathy, P.
10.1101/2025.05.28.656415 — neuroscience — Posted on 2025-05-28
431 EBSn, a robust synthetic reporter for monitoring ethylene responses in plants
Fernandez-Moreno, J.-P.; Fenech, M.; Yaschenko, A. E.; Zhao, C.; Neubauer, M.; Davis, H. N.; Marchi, A. J.; Concannon, R.; Keren-Keiserman, A.; Reuveni, M.; Levitsky, V. G.; Oshchepkov, D.; Dolgikh, V.; Goldshmidt, A.; Ascencio-Ibanez, J. T.; Zemlyanskaya, E.; Alonso, J. M.; Stepanova, A. N.
10.1101/2025.05.23.655144 — plant biology — Posted on 2025-05-28
433 RNA localization to nuclear speckles follows splicing logic
Wen, L.; Arias, M. A.; Fan, X.; Paul, S.; Liao, S. E.; Sobczyk, M.; Regev, O.; Fei, J.
10.1101/2025.05.28.656493 — biochemistry — Posted on 2025-05-28
435 Male gut microbiome mediates post-mating sexual selection in Drosophila
Maggu, K.; Meena, A.; De Nardo, A. N.; Sbilordo, S. H.; Roy, J.; Lüpold, S.
10.1101/2025.05.23.655737 — evolutionary biology — Posted on 2025-05-28
437 Tissue signatures of human macrophages during homeostasis and activation
Caron, D. P.; Specht, W. L.; Chen, D.; Wells, S. B.; Szabo, P. A.; Sims, P. A.; Farber, D. L.
10.1101/2025.05.23.655632 — immunology — Posted on 2025-05-28
438 Comparing Brain-Behavior Relationships Across Dimensional, Tail-Sampled, and Propensity-Matched Models
Murtha, K.; Dorfschmidt, L.; Bethlehem, R. A. I.; Kang, K.; Vandekar, S.; Alexander-Bloch, A. F.; Waller, R.; Seidlitz, J.
10.1101/2025.05.23.655740 — neuroscience — Posted on 2025-05-28
440 Gut microbe-derived lactic acid optimizes host energy metabolism during starvation
Millington, J. W.; Lopez, J. A.; Sajjadian, A. M.; Scheffler, R. J.; DeFelice, B. C.; Ludington, W. B.; Good, B. H.; O'Brien, L. E.; Huang, K. C.
10.1101/2025.05.27.656452 — physiology — Posted on 2025-05-28
443 Description of a new Telonemia genus and species with novel observations providing insights into its hidden diversity
Mostazo-Zapata, H.; Galvez-Morante, A.; Berney, C.; Maya-Figuerola, X.; Sigona, C.; Lopez-Escardo, D.; Sa, E. L.; Vaque, D.; Richter, D. J.
10.1101/2025.05.28.656552 — evolutionary biology — Posted on 2025-05-28
445 Analyses of 37 composts revealed microbial taxa associated with disease suppressiveness
Logo, A.; Boppre, B.; Fuchs, J.; Maurhofer, M.; Oberhaensli, T.; Thuerig, B.; Widmer, F.; Mayerhofer, J.; Flury, P.
10.1101/2025.01.17.633646 — molecular biology — Posted on 2025-05-28
447 The molecular infrastructure of glutamatergic synapses in the mammalian forebrain
Peukes, J.; Lovatt, C.; Leistner, C.; Boulanger, J.; Morado, D. R.; Fuller, M. J. G.; Kukulski, W.; Zhu, F.; Komiyama, N. H.; Briggs, J. A. G.; Grant, S. G. N.; Frank, R. A. W.
10.1101/2021.02.19.432002 — neuroscience — Posted on 2025-05-28
450 The Spinal Cord-Gut Axis Regulates Gut Microbial Homeostasis: Insights from a New Murine Metagenomic Catalog
Mohssen, M.; Zayed, A. A.; Kigerl, K.; Du, J.; Smith, G. J.; Schwab, J. M.; Sullivan, M. B.; Popovich, P. G.
10.1101/2025.05.27.656368 — microbiology — Posted on 2025-05-28
452 Neural responses prior to licking onset in the striatal matrix compartment in mice
Ishimaru, Y.; Yoshizawa, T.; Kimoto, T.; Inui, T.; Yawaka, Y.; Funahashi, M.
10.1101/2025.05.23.655747 — neuroscience — Posted on 2025-05-28
453 Evaporative cooling signals for wound healing in plants
Balem, J. M.; Tan, C.; Dias, N. C. F.; Arnold, M. L.; Tran, S.; Severns, P. M.; Teixeira, P. J. P. L.; Li, C.; Yang, L.
10.1101/2025.05.23.655667 — plant biology — Posted on 2025-05-28
458 Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the anterior brainstem
Kilpinen, S.; Virtanen, L.; Bodington Celma, S.; Bonsdorff, A.; Heliölä, H.; Achim, K.; Partanen, J.
10.1101/2025.01.26.634960 — developmental biology — Posted on 2025-05-28
459 CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages
Hovhannisyan, G. G.; Akhourbi, T.; Eski, S. E.; Pirson, I.; Gurzov, E. N.; Singh, S. P.
10.1101/2025.05.23.655316 — developmental biology — Posted on 2025-05-28
464 Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA)
Smith, R. E.; Christena, R. L.; Michno, B. J.; O'Dea, F.; Davis, J. L.; Lidbury, I. D.; Alaman-Zarate, M.; Stefanidi, D.; Maes, E.; Fisher, H.; Prajsnar, T. K.; Mesnage, S.
10.1101/2024.11.26.625352 — microbiology — Posted on 2025-05-28
465 High-throughput screening for class I peptide MHC binding via yeast surface display
Holec, P. V.; Breuckman, K. C.; Leddy, O.; White, F. M.; Bryson, B. D.; Birnbaum, M. E.
10.1101/2025.05.24.655874 — immunology — Posted on 2025-05-28
467 EEG Signature of Idiopathic Hypersomnia: Insights from Sleep Microarchitecture and Hypnodensity Metrics
Le Coz, A.; Vollhardt, R.; Champetier, P.; Herzog, R.; Leu-Semenescu, S.; Dodet, P.; Attali, V.; Gales, A.; Oudiette, D.; Arnulf, I.; Andrillon, T.
10.1101/2025.05.26.656134 — neuroscience — Posted on 2025-05-28
468 Cholinergic synaptic plasticity shapes resilience and vulnerability to tau
Onuska, K. M.; Devito, L. A.; Shanks, H. R.; Qi, Q.; Crooks, A. M.; Haast, R. A.; Andrews, T. S.; Williams, K. M.; Beraldo, F. H.; Qiu, T.; Fajardo-Valdez, A.; Wearn, A.; Turner, G. R.; Thiessen, J. D.; Fox, M. S.; Hicks, J. W.; Bussey, T. J.; Saksida, L. M.; Tremblay-Mercier, J.; Breitner, J. C.; Soucy, J.-P.; Poirier, J.; Villeneuve, S.; Prado, V. F.; Prado, M. A.; Spreng, R. N.; Schmitz, T. W.; for the PREVENT-AD Research Group,
10.1101/2025.05.27.656174 — neuroscience — Posted on 2025-05-28
469 Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes
Grodem, E. O. S.; Vidal-Pineiro, D.; Sorensen, O.; Bartres-Faz, D.; Brandmaier, A. M.; Cattaneo, G.; Garrido, P. F.; Henson, R. N.; Kühn, S.; Lindenberger, U.; MacIntosh, B. J.; Nyberg, L.; Pascual-Leone, A.; Smith, S. M.; Sole-Padulles, C.; Solana-Sanchez, J.; Watne, L. O.; Walhovd, K. B.; Bjornerud, A.; Fjell, A. M.
10.1101/2025.05.26.655710 — neuroscience — Posted on 2025-05-28
472 Direct observation of conformational dynamics of intrinsically disordered proteins at the single-molecule level
Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.
10.1101/2025.05.26.656162 — biophysics — Posted on 2025-05-28
477 Comparative analysis of the radiobiological effects of laser-driven VHEE vs. conventional electrons using in vitro, ex vivo, and in vivo models
Giaccaglia, C.; Bayart, E.; Dubail, M.; Varma, C.; Heinrich, S.; Gautier, J.; Tafzi, A.; Kononenko, L.; Goddet, J.-p.; Lamarre-Jouenne, I.; Fouillade, C.; Flacco, A.
10.1101/2025.05.27.656200 — cell biology — Posted on 2025-05-28
480 Lactic acid influences iron assimilation by a fungal pathogen via the iron reductive uptake pathway
Gomes-Goncalves, A.; Van Genechten, W.; Ataide, P.; Barata Antunes, C.; Ghasemi, F.; Casal, M.; Teixeira, M. C.; Arino, J.; Brown, A. J. P.; Van Dijck, P.; Paiva, S.
10.1101/2025.05.27.656276 — cell biology — Posted on 2025-05-28
482 Structure of the conjugation surface exclusion protein TraT
Chen, N.; Bukys, A.; Lundgren, C. A.; Deme, J. C.; El Sayyed, H.; Kapanidis, A. N.; Lea, S. M.; Berks, B. C.
10.1101/2025.05.27.656304 — microbiology — Posted on 2025-05-28
483 Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol.
GSCHWIND, R.; Bonnet, M.; Abramova, A.; Jarquin Diaz, V. H.; Wenne, M.; Loeber, U.; Godron, N.; Kampouris, I. D.; Tskhay, F.; Nahid, F.; Debroucker, C.; Bui-Hai, M.; El Aiba, I.; Klumper, U.; Berendonk, T. U.; Forslund-Startceva, S. K.; Zahra, R.; Bengtsson-Palme, J.; RUPPE, E.
10.1101/2025.05.26.656069 — microbiology — Posted on 2025-05-28
484 Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines
Solomon, P. A. J.; Budde, M.; Kohshour, M. O.; Adorjan, K.; Heilbronner, M.; Navarro-Flores, A.; Papiol, S.; Reich-Erkelenz, D.; Schulte, E. C.; Senner, F.; Vogl, T.; Kaurani, L.; Krugger, D. M.; Sananbenesi, F.; Pena, T.; Burkhardt, S.; Schutz, A.-L.; Anghelescu, I.-G.; Arolt, V.; Baune, B. T.; Dannlowski, U.; Dietrich, D. E.; Fallgatter, A. J.; Figge, C.; Juckel, G.; Konrad, C.; Lang, F. U.; Reimer, J.; Reininghaus, E. Z.; SchmauB, M.; Spitzer, C.; Wiltfang, J.; Zimmermann, J.; Fischer, A.; Falkai, P.; Schulze, T. G.; Heilbronner, U.; Poschmann, J.
10.1101/2025.03.28.645923 — immunology — Posted on 2025-05-28
485 Stimulus-Dependent Theta Rhythmic Activity in Primate V1 Predicts Visual Detection
Fanyiwi, P. T.; Agayby, B.; Kienitz, R.; Haag, M.; Cadena-Valencia, J.; Schmid, M. C.
10.1101/2021.11.30.470367 — neuroscience — Posted on 2025-05-28
488 Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation
Sathe, G.; Roth, S.; Gelders, G.; Brewer, A.; Macartney, T.; Wood, N.; De Muynck, L.; Nakasone, M.; Phung, T.; Buist, A.; Moechars, D.; Sapkota, G. P.
10.1101/2025.05.27.656291 — cell biology — Posted on 2025-05-28
496 Changes in social reward across adolescence in male mice
Harda, Z.; Klimczak, M.; Misiolek, K.; Chroszcz, M.; Szumiec, L.; Kaczmarczyk-Jarosz, M.; Rzeszut, A.; Rygula, R.; Ziolkowska, B.; Rodriguez Parkitna, J. M.
10.1101/2025.05.27.656363 — neuroscience — Posted on 2025-05-27
497 Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines
Frazier, S. E. D.; de Lichtenberg, K. H.; Jaberi, E.; Bertelsen, C.; Jensen, S. M.; Wrona, A.; Nielsen, F. M.; Christophersen, N. S.; Kristensen, M.; Villaescusa, J. C.
10.1101/2025.05.27.656305 — neuroscience — Posted on 2025-05-27
498 Focused ultrasound to the bilateral thalamus causally modulates human cognitive attention in a frequency- and intensity-dependent manner
Caulfield, K. A.; Sege, C. T.; Weaver, J.; Murphy, K. R.; Passaro, T.; Meads, K.; Dadgar-Kiani, E.; Antonucci, M. U.; Good, C.; McTeague, L. M.
10.1101/2025.05.27.656481 — neuroscience — Posted on 2025-05-27
499 System-wide dissociation of reward and aversive dopaminergic signals
Bouchard, S.-J.; Bouchard, J.; Levesque, M.; Breton-Provencher, V.
10.1101/2025.05.27.656467 — neuroscience — Posted on 2025-05-27
505 ECD functions as a novel RNA-binding protein to regulate mRNA splicing
Raza, M.; Rajan, A. R.; Kalluchi, A.; Saleem, I.; Kennedy, B. B.; Bhakat, K. K.; Band, H.; Rowley, M. J.; Band, V.
10.1101/2025.01.24.634785 — cell biology — Posted on 2025-05-27
506 Discovering Polyphosphate and Polyhydroxyalkanoate-Accumulating Organisms Across Ecosystems: Phenotype-targeted Genotyping via FACS-sequencing
Yan, Y.; Baldwin, M.; Lee, J.; Wang, Z.; Li, G.; Han, I.; He, P.; Shrinivasan, V.; Wicked-Do, L.; Gore, M.; Gu, A. Z.
10.1101/2025.03.24.644850 — microbiology — Posted on 2025-05-27
508 Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish
Allavena, G.; Rossiello, F.; Idilli, A. I.; Mione, M.; di Fagagna, F. d.; Ferreira, M. G.; Lopes-Bastos, B.
10.1101/2025.05.23.655694 — pathology — Posted on 2025-05-27
512 Modulation of archaeal hypernucleosome structure and stability by Mg2+
Zarguit, I.; Cajili, M. K.; van Erp, B.; Schwab, S.; van der Vis, N.; Bakker, M.; van Noort, J.; Dame, R. T.
10.1101/2025.05.26.656202 — molecular biology — Posted on 2025-05-27
514 Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosis
Gaule, T.; Simmons, K. J.; Walker, K.; Del Galdo, F.; Ross, R. L.; Viswambharan, H.; Krishnappa, J.; Pacey, J.; McPhillie, M.; Tomlinson, D. C.; Maqbool, A.
10.1101/2025.05.23.655116 — physiology — Posted on 2025-05-27
517 Tracing the drivers of range-wide bowhead whale genomic structure and diversity
Westbury, M. V.; Freymueller, N. A.; Cabrera, A. A.; Bachmann, L.; Ferguson, S.; Heide-Jorgensen, M. P.; Kovacs, K. M.; Lydersen, C.; Shpak, O.; Wiig, O.; Fordham, D. A.; Lorenzen, E. D.
10.1101/2025.05.23.655713 — evolutionary biology — Posted on 2025-05-27
519 Structural basis of auxin binding and transport by Arabidopsis thaliana AUX1
Jing, D.; Kong, F.; Lu, X.; Huang, G.; Huang, J.; Wang, H.; Shi, Y.; Wang, C.
10.1101/2025.05.27.656222 — molecular biology — Posted on 2025-05-27
521 Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis
Dey, S.; Cao, J.-H.; Balluff, B.; Dey, N. S.; Gilbert, L.; James, S. R.; Dowle, A.; Calder, G.; O'Toole, P.; Heeren, R. M. A.; Kaye, P. M.
10.1101/2025.05.23.655708 — immunology — Posted on 2025-05-27
522 Correlations of neural predictability and information transfer in cortex and their relation to predictive coding
Fiorenza, J. P.; Le Donne, L.; Schmidt-Samoa, C.; Heide, E.- C.; von der Brelie, C.; Malinova, V.; Focke, N. K.; Wilke, M.; Melloni, L.; Schwiedrzik, C. M.; Wibral, M.
10.1101/2025.05.23.655705 — neuroscience — Posted on 2025-05-27
525 Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ
de Oliveira Silva, Y. R.; Barnes, G.; Zheng, D.; Zhitnitsky, D.; Geathers, S. J.; Peters, S. C.; Szalai, V. A.; Helmann, J. D.; Fisher, O. S.
10.1101/2025.05.23.655588 — biochemistry — Posted on 2025-05-27
527 A flexible end-to-end automated sample preparation workflow enables reproducible large-scale bottom-up proteomics
Raess, L.; Schaer, S.; Malinovska, L.; Savickas, S.; Cavallo, F.; Below, C. R.; Tognetti, M.; Shichkova, P.; Gourdet, B.; Robles, G.; Iu, L.; Vowinckel, J.; Feng, Y.; Hjerpe, R.; Bruderer, R.; Reiter, L.
10.1101/2025.05.23.655690 — biochemistry — Posted on 2025-05-27
528 Comparative genomic analysis of Cluster AZ Arthrobacter phages
Freise, A. C.; Furlong, K. P.; Klyczek, K. K.; Beyer, A. R.; Chong, R. A.; Edgington, N. P.; Gibb, B. P.; Swerdlow, S. J.; Bendele, M. G.; Cobb, I. D.; Mitchell, Z. J.; Cresawn, S. G.; Garcia Costas, A. M.; Rudner, A. D.
10.1101/2025.05.26.655371 — genomics — Posted on 2025-05-27
531 Climate associated natural selection in the human mitochondrial genome
Grover-Thomas, F.; van Dorp, L.; Balloux, F.; Andres, A. M.; Camus, M. F.
10.1101/2025.05.23.655374 — evolutionary biology — Posted on 2025-05-27
533 Biodiversity State Indicator: Integrating taxonomy, functionality and species interactions
Mortensen, L. O.; Brodnicke, O. B.; Devantier, C. B.; Ferreira, S. A.; Wong, X. H.; Schrameyer, V.
10.1101/2025.05.23.655681 — ecology — Posted on 2025-05-27
535 Pathological meprin α expression associated with degradation of dermokine drives a psoriasis-like skin phenotype in a genetic mouse model
Köhling, V.; Peters, F.; Götting, I.; Fries, E.; Beck, N.; Armbrust, F.; Beckinger, S.; Bülck, C.; Canbay, V.; Harder, I.; Mengel, M.; Rüffer, M.; Bickenbach, K.; Kalogeropoulos, K.; Schweizer, M.; Schumacher, N.; Haase, M.; Naumann, R.; auf dem Keller, U.; Becker-Pauly, C.; Rüffer, S.
10.1101/2025.05.23.655724 — molecular biology — Posted on 2025-05-27
536 Structure of the conjugation surface exclusion protein TraT
Berks, B. C.; Chen, N.; Bukys, A.; Lundgren, C. A.; Deme, J. C.; El Sayyed, H.; Kapanidis, A. N.; Lea, S. M.
10.1101/2025.05.27.656304 — microbiology — Posted on 2025-05-27
537 Sedative choice alters Klebsiella pneumoniae lung pathogenesis and dissemination
Mains, D.; Rotman, E. R.; Aman, D. K.; Ludvik, D. A.; Desikan, A.; Kocher, A. A.; Mandel, M. J.; Freitag, N. E.
10.1101/2025.05.27.656367 — microbiology — Posted on 2025-05-27
540 Virus-mediated recycling of chemoautotrophic biomass
Luo, E.; Pham, N. D.; Rogers, T. J.; Vallino, J. J.; Benner, B. E.; Trubl, G.; Huber, J. A.
10.1101/2025.05.27.656380 — microbiology — Posted on 2025-05-27
541 Myeloid-specific TFAM deficiency drives mitochondrial DNA stress and exacerbates allergic airway inflammation
Nguyen, J.; Van, C.; Karpurapu, M.; Kim, J.; Lee, T. J.; Yoo, J. Y.; Pabla, N. S.; Christman, J.; Chung, S.
10.1101/2025.05.27.654580 — immunology — Posted on 2025-05-27
542 Stress-Induced Alteration of Small Extracellular Vesicles Drives Amyloid-Beta Sequestration and Exacerbates Alzheimer's Disease Pathogenesis
Kumar, S.; Zehra, S.; Rai, S.; Rani, K.; Choudhury, S. D.; Rai, H.; Bhowmik, S.; Mohan, N.; Gupta, A.; Chatterjee, P.; Reddy, T. J.; Rani, N.; Modi, G. P.; Nikolajeff, F.
10.1101/2025.05.23.655679 — neuroscience — Posted on 2025-05-27
546 Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations.
Philips, E. A.; Alharithi, Y.; Wilson, T. D.; Broberg, C.; Davis, B. A.; Koch, S.; Carbone, L.; Rubinstein, J.; Gurley, S. B.; Rugonyi, S.; Kumar, S.; Maloyan, A.
10.1101/2025.04.15.648971 — molecular biology — Posted on 2025-05-27
548 A Biosynthetic Thumb Prosthesis
Bansal, S.; Lai, G. V.; Belingheri, M.; Kashay, A. Q.; Kim, J. K.; Tomkinson, A.; Herman, S.; Bollavaram, K.; Zukotynski, B. K.; Jain, N. S.; Azari, K. K.; Wessel, L. E.; Clites, T. R.
10.1101/2025.05.23.655850 — bioengineering — Posted on 2025-05-27
550 Scaled multidimensional assays of variant effect identify sequence-function relationships in hypertrophic cardiomyopathy
Yamamoto, Y.; Chua, K.; Ferrasse, A.; Kirillova, A.; De Jong, H.; Floyd, B.; Cadisch, C.; Wiel, L.; Wang, Q.; O'Neill, M.; Tabet, D. R.; Staudt, D. W.; Gorzynski, J. E.; Huang, Y.; Wilson, R. H.; Sharma, A.; Tapales, A.; Agrawal, R.; Wheeler, M. T.; MacRae, C. A.; Roden, D. M.; Roth, F.; Glazer, A. M.; Ashley, E. A.; Parikh, V. N.
10.1101/2025.05.23.655878 — genetics — Posted on 2025-05-27
551 Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development
Peters, L. D.; Brusko, M. A.; Seay, H. R.; Posgai, A. L.; Wasserfall, C. H.; Atkinson, M. A.; Bacher, R.; Brusko, T. M.
10.1101/2025.05.23.655848 — immunology — Posted on 2025-05-27
556 The evolution of pectate lyase-like genes across land plants, and their roles in haustorium formation in parasitic plant, Triphysaria versicolor (Orobanchaceae)
Zhang, H.; Wafula, E. K.; Kelly, E. M.; Ko, I.; Yocca, A.; Bandaranayake, P. C. G.; Yang, Z.; Steele, D. B.; Yoder, J.; Honaas, L.; dePamphilis, C.
10.1101/2024.12.04.626843 — plant biology — Posted on 2025-05-27
557 The Global Wheat Full Semantic Organ Segmentation (GWFSS) dataset
Wang, Z.; Zenkl, R.; Greche, L.; De Solan, B.; Bernigaud Samatan, L.; Ouahid, S.; Visioni, A.; Robles-Zazueta, C. A.; Pinto, F.; Perez-Olivera, I.; Reynolds, M. P.; Zhu, C.; Liu, S.; D'argaignon, M.-P.; Lopez-Lozano, R.; Weiss, M.; Marzougui, A.; Roth, L.; Dandrifosse, S.; Carlier, A.; Dumont, B.; Mercatoris, B.; Fernandez, J.; Chapman, S.; Najafian, K.; Stavness, I.; Wang, H.; Guo, W.; Virlet, N.; Hawkesford, M.; Chen, Z.; David, E.; Gillet, J.; Irfan, K.; Comar, A.; Hund, A.
10.1101/2025.03.18.642594 — plant biology — Posted on 2025-05-27
559 Monitoring the Coating of Single DNA Origami Nanostructures with a Molecular Fluorescence Lifetime Sensor
Scheckenbach, M.; Brueggenthies, G. A.; Schroeder, T.; Betuker, K.; Wassermann, L. M.; Tinnefeld, P.; Heuer-Jungemann, A.; Glembockyte, V.
10.1101/2024.10.28.620667 — biophysics — Posted on 2025-05-27
561 Direct observation of single intrinsically disordered proteins in solution
Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.
10.1101/2025.05.26.656162 — biophysics — Posted on 2025-05-27
562 Elevational and Oceanic Barriers Shape the Distribution, Dispersal and Diversity of Aotearoa's Kapokapowai (Uropetala) Dragonflies
Tolman, E. R.; Beatty, C. D.; Goodman, A. G.; Ramchand, P.; McAllister, T.; Reyes, K.; Zahara, A.; Taveras, K.; Wade, V.; Abbott, J.; Guralnick, R.; Harding, K. M.; Kohli, M. K.; Frandsen, P. B.; Ware, J. L.; Suvorov, A.
10.1101/2024.11.25.625207 — evolutionary biology — Posted on 2025-05-27
565 The cellular and behavioral blueprints of chordate rheotaxis.
Tolstenkov, O.; Ozawa, A.; Allombert-Blaise, C.; Hoyer, J.; Hiraiwa, T.; Chatzigeorgiou, M.
10.1101/2025.03.22.644710 — neuroscience — Posted on 2025-05-27
567 The molecular infrastructure of glutamatergic synapses in the mammalian forebrain
Peukes, J.; Lovatt, M.; Leistner, C.; Boulanger, J.; Morado, D. R.; Fuller, M. J. G.; Kukulski, W.; Zhu, F.; Komiyama, N. H.; Briggs, J. A. G.; Grant, S. G. N.; Frank, R. A. W.
10.1101/2021.02.19.432002 — neuroscience — Posted on 2025-05-27
568 Promoting social connectedness through multi-person neurofeedback
Cheng, X.; Zhang, R.; Chen, P.; Song, Z.; Cheng, F.; Dikker, S.; Pan, Y.
10.1101/2025.05.22.655644 — neuroscience — Posted on 2025-05-27
570 NeuroSC: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks
Koonce, N. L.; Emerson, S. E.; Bhaskar, D.; Kuchroo, M.; Moyle, M. W.; Arroyo-Morales, P.; Martinez, N. V.; Emerson, J. I.; Krishnaswamy, S.; Mohler, W.; Colon-Ramos, D.
10.1101/2024.08.27.609993 — neuroscience — Posted on 2025-05-27
571 Increased Postprandial Metabolic Flexibility is Associated with Higher Body Fat Percentages in Healthy Young Adults
Foreman, N. A.; Rajwade, S.; Bluth, J.; Skoglund, L.; Letts, A. M.; DiPietro, L.; Ciarleglio, A.; Barberio, M.
10.1101/2024.08.23.609405 — physiology — Posted on 2025-05-27
573 WITHDRAWN: Cell based dATP delivery as a therapy for chronic heart failure.
Mhatre, K. N.; Mathieu, J.; Martinson, A.; Flint, G.; Blakley, L. P.; Tabesh, A.; Reinecke, H.; Yang, X.; Guan, X.; Murali, E.; Klaiman, J. M.; Odom, G. L.; Brown, M. B.; Tian, R.; Hauschka, S. D.; Raftery, D.; Moussavi-Harami, F.; Regnier, M.; Murry, C. E.
10.1101/2023.04.24.538108 — pathology — Posted on 2025-05-27
575 Spike Train Scalograms (STS): a Deep Learning Classification Pipeline for Neuronal Cell Types
Amprimo, G.; Martini, L.; Bilir, B.; Bardini, R.; Savino, A.; Olmo, G.; Di Carlo, S.
10.1101/2025.02.10.637424 — bioinformatics — Posted on 2025-05-27
580 First full-genome alignment representative for the genus Pestivirus
Triebel, S.; Eulenfeld, T.; Ontiveros-Palacios, N.; Sweeney, B.; Tautz, N.; Marz, M.
10.1101/2025.05.22.655560 — bioinformatics — Posted on 2025-05-27
583 Cellular metabolic state controls mitochondrial RNA kinetics
Reardon, S. D.; Bautista, C.; Cole, S. C.; Cicero, J.; Mishanina, T. V.
10.1101/2025.05.13.653903 — molecular biology — Posted on 2025-05-27
585 MACHINE LEARNING FOR MISSING DATA IMPUTATION IN ALZHEIMER'S RESEARCH: PREDICTING MEDIAL TEMPORAL LOBE FLEXIBILITY
Moallemian, S.; Saghafi, A.; Deshpande, R.; Perez, J. M.; Budak, M.; Fausto, B. A.; Elahi, F.; Gluck, M. A.
10.1101/2025.05.22.655574 — neuroscience — Posted on 2025-05-27
587 Chondrocyte-Specific Knockout of Piezo1 and Piezo2 Protects Against Post-Traumatic Osteoarthritis Structural Damage and Pain in Mice
Ely, E.; Lenz, K.; Paradi, S.; Ack, S.; Behrmann, A.; Dunivan, S.; Braxton, L.; Liedtke, W.; Chen, Y.; Collins, K. H.; Guilak, F.
10.1101/2025.05.22.655585 — physiology — Posted on 2025-05-27
589 JMod: Joint modeling of mass spectra for empowering multiplexed DIA proteomics
McDonnell, K.; Wamsley, N.; Derks, J.; Sipe, S.; Yeh, M.; Specht, H.; Slavov, N.
10.1101/2025.05.22.655512 — bioinformatics — Posted on 2025-05-27
591 Increasing mass spectrometry throughput using time-encoded sample multiplexing
Derks, J.; McDonnell, K.; Wamsley, N.; Stewart, P.; Yeh, M.; Specht, H.; Slavov, N.
10.1101/2025.05.22.655515 — bioengineering — Posted on 2025-05-27
592 PSMtags improve peptide sequencing and throughput in sensitive proteomics
Specht, H.; Yeh, M.; Sipe, S.; Barnes-Seeman, D.; Adamo, M.; McDonnell, K.; Agius, M. P.; Friedrich, C.; Pang, W. K.; Huang, Y.; Shiva Raju, K.; Vuong, W.; Lee, M. A.; Yesilcimen, A.; Pentelute, B. L.; Slavov, N.
10.1101/2025.05.22.655509 — bioengineering — Posted on 2025-05-27
593 Hyperglycemic state and fluid shear stress affect metastatic breast cancer cell migration via focal adhesion kinase
Riehl, B. D.; Kim, E.; Boudreaux, T.; Ovando, O.; Vielmas-Duarte, S.; Choi, S.; Band, H.; Mei, L.; Dutta, D.; Chandra, S.; Lim, J. Y.
10.1101/2025.05.22.655615 — bioengineering — Posted on 2025-05-27
594 Synchronization of the collective air-breathing behavior in juvenile Arapaima gigas
Bartashevich, P.; Francisco, F. A.; Escurra-Alegre, A.; Schaefer, F.; Wuertz, S.; Krause, J.; Kloas, W.; Bierbach, D.
10.1101/2025.05.22.655545 — animal behavior and cognition — Posted on 2025-05-27
595 Comprehensive detection of structural variations in long and short reads dataset of French cattle
Naji, M. M.; Klopp, C.; Faraut, T.; Eche, C.; Di Franco, A.; Birbes, C.; Marcuzzo, C.; Suin, A.; Iampietro, C.; Kuchly, C.; Vernette, C.; Fritz, S.; Grohs, C.; Gaspin, C.; Milan, D.; Donnadieu, C.; Boichard, D.; Sanchez, M.-P.; Boussaha, M.
10.1101/2025.05.22.654398 — genomics — Posted on 2025-05-27
603 METTL3 regulates exocytosis independently of m6A
Esteva-Socias, M.; Bhattarai, D. P.; Achour, C.; Baidya, P.; Fontanari, G.; Seier, K.; Pace, H.; Malla, S.; Zhu, S.; Lundin, E.; Vagbo, C. B.; Bally, M.; Swaminathan, V. S.; Mateus, A.; Rodriguez-Barrueco, R.; Pich, A.; Aguilo, F.
10.1101/2025.05.26.656168 — molecular biology — Posted on 2025-05-27
605 Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease
D'Addario, S. L.; Massaro Cenere, M.; Cossa, F.; Scaricamazza, S.; Nesci, V.; D'Ottavio, G.; Caprioli, D.; Ferri, A.; Vila, M.; Ledonne, A.; Mercuri, N. B.
10.1101/2025.04.18.649338 — neuroscience — Posted on 2025-05-27
606 Combining cortical and spinal stimulation maximizes improvement of gait after spinal cord injury
Drainville, R.; Bonizzato, M.; Burchielli, D.; Guay-Hottin, R.; Sheasby, A.; Martinez, M.
10.1101/2025.05.22.655593 — neuroscience — Posted on 2025-05-27
607 Epigenetic modifiers to treat retinal degenerative diseases
Popova, E.; Schneper, L.; Sebastian, A.; Albert, I.; Tombran-Tink, J.; Barnstable, C.
10.1101/2025.05.22.655558 — neuroscience — Posted on 2025-05-27
612 FoldBench: An All-atom Benchmark for Biomolecular Structure Prediction
Xu, S.; Feng, Q.; Qiao, L.; Wu, H.; Shen, T.; Cheng, Y.; Zheng, S.; Sun, S.
10.1101/2025.05.22.655600 — bioinformatics — Posted on 2025-05-27
616 PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.
Sarkar, B.; Singh, J.; Yadav, M.; Sharma, P.; Sharma, R. D.; Singh, S.; Chandramouli, A.; Mehdiratta, K.; Kumar, A.; Kamat, S. S.; Ghorpade, D. S.; Mohanty, D.; Kumar, D.; Gokhale, R. S.
10.1101/2024.02.02.578554 — microbiology — Posted on 2025-05-27
617 Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer
Hope, J. L.; Zhang, Y.; Hetrick, H. A. F.; Sanchez-Hernandez, E. S.; Silvestri, B.; Smith, B. J.; Nakil, S. H.; Roy, S.; Lin, M.; Palete, A. B.; Maganti, S.; Ling, L.; Otero, D. C.; Byrne, K.; Romano, G.; Wang, Y. X.; Commisso, C.; Bradley, L. M.
10.1101/2025.05.22.655365 — immunology — Posted on 2025-05-27
618 Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence
Rubinic, M.; Arias-Rojas, A.; Martinez, K. A.; Klimek, W.; Paczia, N.; Alagesan, K.; Duneau, D.; Iatsenko, I.
10.1101/2025.05.22.655590 — immunology — Posted on 2025-05-27
623 A complete suite for compact programming of protein secretion
Vlahos, A. E.; Call, C. C.; Eckman, N.; Kadaba, S. E.; Guo, S.; Thurm, A. R.; Kang, J.; Appel, E.; Bintu, L.; Gao, X. J.
10.1101/2023.10.04.560774 — synthetic biology — Posted on 2025-05-27
624 Beyond binding motif: genomic context predicts transcription factor dependent regulation in Arabidopsis
Turchi, L.; Lucas, J.; Tichtinsky, G.; Thierry-Mieg, N.; Blanc-Mathieu, R.; Parcy, F.; Frenoy, A.
10.1101/2025.05.23.655699 — plant biology — Posted on 2025-05-27
625 Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice
Park-sigal, J. J.; Norton, M.; Tu, C.-L.; Cheng, Z.; Fadahunsi, N.; Lee, H.; Kim, S.; Li, A.; Grinberg, L. T.; Bewick, G. A.; Murphy, K. G.; Chang, W. A.
10.1101/2025.05.22.655605 — physiology — Posted on 2025-05-27
626 Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules
Cassell, S. J.; Li, W.; Krautwald, S.; Khoshouei, M.; Lee, Y. T.; Hou, J.; Guan, W.; Peukert, S.; Weihofen, W.; Whicher, J.
10.1101/2025.05.22.655589 — pharmacology and toxicology — Posted on 2025-05-27
629 Multiscale Segmentation using Hierarchical Phase-contrast Tomography and Deep Learning
Zhou, Y.; Aslani, S.; Javanmardi, Y.; Brunet, J.; Stansby, D.; Carroll, S.; Bellier, A.; Ackermann, M.; Tafforeau, P.; Lee, P. D.; Walsh, C. L.
10.1101/2025.05.15.654263 — bioinformatics — Posted on 2025-05-27
632 CRISPR activation screens map the genomic landscape of cancer glycome remodeling
Daly, J.; Piatnitca, L.; Al-Seragi, M.; Krishnamoorthy, V.; Wisnovsky, S.
10.1101/2025.05.26.656133 — genomics — Posted on 2025-05-27
635 Gene expression reveals the pancreas of Aselli as a critical organ for plasma cell differentiation in the common shrew
Thomas, W. R.; Baldoni, C.; Lama, T. M.; Zeng, Y.; Corthals, A. P.; von Elverfeldt, D.; Nieland, J.; Dechmann, D. K. N.; Davalos, L.
10.1101/2025.05.22.654563 — evolutionary biology — Posted on 2025-05-27
636 Fish remain high in selenium long after mountaintop coal mines close
Cooke, C.; Graydon, J.; Luek, A.; Lu, X.; Yu, H.; Le, X. C.; Reichert, M.
10.1101/2025.05.22.655156 — ecology — Posted on 2025-05-27
638 A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets
Fye, M. A.; Sharma, R.; Myat, P. S. M.; Regan, P.; McKinney, H.; Gu, G.; Kaverina, I.
10.1101/2025.04.22.650066 — cell biology — Posted on 2025-05-27
640 Effect of Age on Xenobiotic-Induced Autoimmunity
de Ocampo, C.; Peiss, A. K.; Leung, H. Y.; Janssen, L. M.; Kono, D. H.; Mayeux, J. M.; Pollard, K. M.
10.1101/2025.05.22.655368 — immunology — Posted on 2025-05-27
643 Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres
Lopez Rodriguez, D.; Pamies, D.; Boccard, J.; Meister, I.; Galmiche, M.; Sajic, T.; Maret, E.; Heritier, N.; Frangiamone, M.; Thomas, A.; Hopf, N.; Rudaz, S.; Zurich, M.-G.
10.1101/2025.05.22.655411 — pharmacology and toxicology — Posted on 2025-05-27
644 Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension
Villarreal, E. S.; Marinho, Y.; Loya, O.; Aboagye, S. Y.; Williams, D. L.; Sun, J.; Erzurum, S.; de Jesus Perez, V.; Oliveira, S. D.
10.1101/2025.05.22.655387 — pharmacology and toxicology — Posted on 2025-05-27
648 A resource and computational approach for quantifying gene editing allelism at single-cell resolution
Ung, M. H.; Angelini, G.; Wang, R.; Pyclik, A.; Lydeard, J.; Ferrucio, J.; Lin, M.; Ge, H. G.
10.1101/2025.05.22.653824 — bioinformatics — Posted on 2025-05-27
651 PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization
Harold, K. M.; Matsuzaki, S.; Pranay, A.; Zhu, J.; Faakye, A.; Humphries, K. M.
10.1101/2025.05.26.656235 — biochemistry — Posted on 2025-05-27
653 Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age
Woo, Q. Y.; Lee, B. T. K.; Lim, L. W.; Zhang, J.; Tashiro, A.; Lau, P. K.; Thibault, G.; Wang, Y.; Lin, V. C. L.
10.1101/2025.05.22.655437 — animal behavior and cognition — Posted on 2025-05-27
654 Metaproteomics revealing cyanide bioremediators in effluents from artisanal cassava processing in the Brazilian Amazon
Maciel, A. C.; NAHON, S. M. R.; COSTA, I. R. C. d.; Valadares, R.; PHILIPPSEN, H. K.; BAHULE, C. E.; CHAUQUE, B. J. M.; GUIMARAES, K. H. A.; ARAUJO, N. M. P.; LOPES, A. S.; Maciel, A.
10.1101/2025.05.20.655124 — genomics — Posted on 2025-05-27
655 Variant Set Distillation
Christ, R.; Kang, C. J.; Aslett, L.; Lam, D.; Savitski, M. F.; Stitziel, N. O.; Steinsaltz, D.; Hall, I.
10.1101/2024.12.06.627210 — genomics — Posted on 2025-05-27
657 Long-term surveillance suggests multiple hybridization events by nuclear reassortment and accelerated intercontinental spread of wheat yellow rust
Hovmoeller, M. S.; Thach, T.; Algaba, J. R.; Hansen, J. G.; Meyer, M.; Hodson, D.; Nazari, K.; Park, R. R.; Tamm, R.; Moeller, M.; Schwessinger, B.; Rathjen, J. P.; Silva, P.; Riella, V.; Justesen, A. F.
10.1101/2025.05.22.655633 — evolutionary biology — Posted on 2025-05-27
660 A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome
Deng, K.; Wang, Y.; Mic, J. C.; Liu, X.; Myers, G.; Yu, L.; Hammoud, S.; Adam, A.; Saba, R.; Natogi, V.; Drysdale, C.; Chen, B.; Ueharu, H.; Yee, J. L.; Kitzman, J.; Lyssiotis, C. A.; Mishina, Y.; Jones, M.; Kaartinen, V.; Guan, Y.; Khoriaty, R.; Engel, J. D.; Singh, S. A.
10.1101/2025.05.22.654334 — developmental biology — Posted on 2025-05-27
663 Postpartum cytokine shifts and IL-10-mediated immune suppression in malaria-infected primigravid women
TRAORE, O.; Rouamba, T.; Zango, S. H.; Sorgho, H.; Valea, I.; Traore-Coulibaly, M.; Schallig, H. D. F. H.; Tinto, H.
10.1101/2025.05.21.655391 — immunology — Posted on 2025-05-27
665 A Python Toolbox for Representational Similarity Analysis
van den Bosch, J. J.; Golan, T.; Peters, B.; Taylor, J.; Shahbazi, M.; Lin, B.; Charest, I.; Diedrichsen, J.; Kriegeskorte, N.; Mur, M.; Schuett, H.
10.1101/2025.05.22.655542 — neuroscience — Posted on 2025-05-27
667 Mating status-dependent dopaminergic modulation of auditory sensory neurons in Drosophila
Yamakoshi, H.; Horigome, M.; Yamamoto, S.; Iwanami, S.; Iwami, S.; Tanaka, R.; Ishikawa, Y.; Kamikouchi, A.
10.1101/2025.05.22.655009 — neuroscience — Posted on 2025-05-27
668 Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans
Zarodniuk, M.; Wenninger, A.; Najera, J.; Lee, J.; Markillie, J.; MacKenzie, C.; Bergqvist-Patzke, J.; Batista, B.; Panchbhavi, M.; Rumbach, R. n.; Burchett, A.; Datta, M.; Patzke, C.
10.1101/2025.05.22.655651 — neuroscience — Posted on 2025-05-27
670 Head-related transfer function predictions reveal dominant sound transmission mechanisms in a dolphin head
Cheong, Y.; Ruesch, A.; Schalles, M.; Kainerstorfer, J.; Shinn-Cunningham, B. G.; Lee, W.-J.
10.1101/2025.05.22.655550 — biophysics — Posted on 2025-05-27
671 Putting a lid on it: The N-terminal helix of Arf1 inhibits switching via uniform stabilization of the native state
Peters, E. V. A.; Koduru, T.; Hantman, N. A.; McCallum, S. A.; Huang, Q.; Cherfils, J.; Royer, C. A.
10.1101/2025.04.22.650101 — biophysics — Posted on 2025-05-27
672 Deep Learning-Based Methods for Automated Estimation of Insect Length, Volume, and Biomass
Shirali, H.; Ascenzi, A.; Wuehrl, L.; Beyer, N.; DI LORENZO, N.; VACCARELLA, E.; KLUG, N.; MEIER, R.; CERRETTI, P.; Pylatiuk, C.
10.1101/2025.05.22.655251 — bioinformatics — Posted on 2025-05-27
673 Deep Learning for Predicting Stem Cell Efficiency for use in Beta Cell Differentiation
Schoeb, F. J.; Binder, A.; Zamarian, V.; Sordi, V.; Scholz, H.; Malthe-Sorenssen, A.; Dysthe, D. K.
10.1101/2025.05.22.652867 — bioinformatics — Posted on 2025-05-27
674 Engineering Large-Scale and Innervated Functional Human Gut for Transplantation
Poling, H. M.; Noel, T.; Singh, A.; Fisher, G. W.; Thorner, K.; Chaturvedi, P.; Nattamai, K.; Srivastava, K.; Batie, M. R.; Hausfeld, T.; Pitstick, A. L.; Brown, N. E.; MENORET, S.; Anegon, I.; Barrile, R.; Mayhew, C. N.; Takebe, T.; Wells, J. M.; Helmrath, M. A.; Mahe, M. M.
10.1101/2025.05.22.655510 — bioengineering — Posted on 2025-05-27
675 A checklist of alien taxa for South Africa
Zengeya, T. A.; Faulkner, K. T.; Mtileni, M. M.; Winzer, L. L. F.; Kumschick, S.; McCulloch-Jones, E. J.; Miza-Tshangana, S. A.; Robinson, T. B.; Sifuba, A.; Engelbrecht, W.; van Wilgen, B. W.; Wilson, J. R.
10.1101/2025.05.22.655507 — ecology — Posted on 2025-05-27
676 Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages
Fountain, A.; Mansat, M.; Lackraj, T.; Gimenez, M. C.; Moussaoui, S.; Ezzo, M.; Soffiaturo, S.; Urdaneta, E.; Verdawala, M. B.; Fung, K.; Lancaster, C.; Somerville, E.; Hinz, B.; Terebiznik, M.; Botelho, R. J.
10.1101/2024.07.31.605905 — cell biology — Posted on 2025-05-27
678 PDCD1 expression increases at elevated temperatures.
Toma-Jonik, A.; Janus, P.; Mrowiec, K.; Vydra, N.; Sarkowicz, K.; Bar, M.; Mirek, J.; Olbryt, M.; Fidyk, W.; Widlak, W.
10.1101/2025.05.22.652424 — immunology — Posted on 2025-05-27
682 metagRoot: A comprehensive database of protein families associated with plant root microbiomes
Chasapi, M. N.; Chasapi, I. N.; Aplakidou, E.; Baltoumas, F. A.; Karatzas, E.; Iliopoulos, I.; Stravopodis, D. J.; Emiris, I. Z.; Buluc, A.; Georgakopoulos Soares, I.; Kyrpides, N.; Pavlopoulos, G. A.
10.1101/2025.05.22.653656 — bioinformatics — Posted on 2025-05-27
683 OPTRACE: Optical Imaging Guided Transplantation and Tracking of Cells in the Mouse Brain
Wang, J.; Russell, C.; Walczak, M.; Gao, D.; Qiao, G.; Fan, X.; Chu, C.; Janowski, M.; Walczak, P.; Liang, Y.
10.1101/2025.05.24.655973 — bioengineering — Posted on 2025-05-27
684 Complex compositional and functional diversity of venom metalloproteinases in African puff adders
Wilkinson, M. C.; Modahl, C.; Saviola, A.; Albulesco, L.-O.; Tianyi, F.-L.; Harrison, R. A.; Casewell, N. R.
10.1101/2024.05.31.596867 — biochemistry — Posted on 2025-05-27
685 Comparative genomics of Rickettsiella bacteria reveal variable metabolic pathways potentially involved in symbiotic interactions with arthropods
Floriano, A. M. M.; El-Filali, A.; Amoros, J.; Buysse, M.; Jourdan-Pineau, H.; Sprong, H.; Kohl, R.; Dirks, R. P.; Schaap, P.; Koehorst, J.; Nijsse, B.; Bouchon, D.; Daubin, V.; Vavre, F.; Duron, O.
10.1101/2024.12.03.626579 — evolutionary biology — Posted on 2025-05-27
688 Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis
Basu, S.; Steenbergen, P.; Gabler, F.; Paix, A.; Ronchi, P.; Bourenkov, G.; Schneider, T.; Hellgoth, J.; Kreshuk, A.; Ozbek, S.; Ikmi, A.
10.1101/2025.05.26.656114 — developmental biology — Posted on 2025-05-27
693 Unveiling functional-metabolic synergy in the healthy brain: multivariate integration of dynamic FDG-PET and resting-state fMRI
Tarricone, C.; Vallini, G.; Baron, G.; Silvestri, E.; Volpi, T.; Vlassenko, A. G.; Goyal, M. S.; Bertoldo, A.
10.1101/2025.05.21.655345 — neuroscience — Posted on 2025-05-27
694 Effects of speaker and listener sex on auditory attention decoding performance
Van de Ryck, I.; Heintz, N.; Rotaru, I.; Fieberg, D.; Bertrand, A.; Francart, T.
10.1101/2025.05.22.655324 — neuroscience — Posted on 2025-05-27
695 Interictal activity fluctuations follow rather than precede seizures on multiple time scales in a mouse model of focal cortical dysplasia
Kudlacek, J.; Chvojka, J.; Kralikova, M.; Kylarova, S.; Ravi, T.; Novak, O.; Otahal, J.; Balastik, M.; Jiruska, P.
10.1101/2025.05.22.655485 — neuroscience — Posted on 2025-05-27
697 Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions
Greter, G.; Hummel, S.; Kuenzli, D.; Duenki, N.; Ruoho, N.; Burkhardt, P.; Ganguillet, S.; Radiom, M.; Moresi, C.; Laganenka, L.; Hardt, W.-D.; Geisel, S.; Jordi, S.; Misselwitz, B.; Yilmaz, B.; Slomka, J.; Secchi, E.; Stocker, R.; Slack, E.; Arnoldini, M.
10.1101/2025.05.22.655445 — systems biology — Posted on 2025-05-27
698 The maternal inflammatory proteome during pregnancy and its role in predicting the risk of spontaneous preterm birth
Laleye, F.; Jackson, R.; Mi, J. D.; Shennan, A. H.; Hezelgrave - Elliott, N.; Vigilante, A.; Camunas-Soler, J.; Rasmussen, M.; Tribe, R. M.
10.1101/2025.05.19.654577 — systems biology — Posted on 2025-05-27
700 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-05-27
701 PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
Young, A. A.; Juhler, I. G.; Pierce, J. R.; Bohlin, H. E.; Onishile, D. S.; Chua, R. N.; Liu, M. E.; Gardner, E. N.; Cottrell, K. A.
10.1101/2025.05.27.656288 — cancer biology — Posted on 2025-05-27
703 DrugForm-DTA: Towards real-world drug-target binding Affinity Model
Khokhlov, I.; Tashchilova, A.; Bugaev-Makarovskiy, N.; Glushkova, O.; Yudin, V.; Keskinov, A.; Yudin, S.; Svetlichnyy, D.; Skvortsova, V.
10.1101/2025.05.22.655461 — bioinformatics — Posted on 2025-05-27
706 Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation
Gurung, R.; Lee, C. J. M.; Liehn, E. A.; Nurjanah, S.; Ren, M.; van Kan, J. A.; Villanueva, E.; Amrute, J. M.; Loong, S.; Ackers-Johnson, M.; Ruberto, F. P.; Ng, S. L.; Loo, Y. X.; Chu, J.; Lin, X. Y.; Karampinos, K. I.; Kofidis, T.; Lavine, K. J.; Singaraja, R. R.; Sorokin, V.; Foo, R. S.-Y.
10.1101/2025.05.22.655434 — genomics — Posted on 2025-05-27
708 Transcriptomic basis of within- and trans-generational predator-induced plasticity in the freshwater snail Physa acuta
Dejeux, L.; Saclier, N.; Tariel-Adam, J.; Hoareau, M.; Lefebure, T.; Konecny, L.; Plenet, S.; Luquet, E.
10.1101/2024.10.16.618730 — evolutionary biology — Posted on 2025-05-27
713 RHD6LA regulates root hair responses to both symbionts and commensals
Tedeschi, F.; Andersen, S. U.; Quilbe, J.; Fechete, L. I.; Christiansen, S. J.
10.1101/2025.05.22.655471 — molecular biology — Posted on 2025-05-27
714 Expansion, functional diversification and gene fusion events in the Ato protein family
Ghasemi, F.; Antunes, C. B.; Pyrris, Y.; Ataide, P.; Alves, J.; Fernandes, V.; Alves, R.; Goncalves, A. G.; Casal, M.; Van Genechten, W.; Nysten, J.; Brown, A. J. P.; Van Dijck, P.; Diallinas, G.; Pittis, A. A.; Soares-Silva, I.; Paiva, S.
10.1101/2025.05.26.656167 — microbiology — Posted on 2025-05-27
717 Patterns of Structural Disconnection Driving Proprioceptive Deficits After Stroke
Kaeja, M.; Gajiyeva, L.; Iturria-Medina, Y.; Villringer, A.; Sehm, B.; Steele, C. J.
10.1101/2025.05.22.655663 — neuroscience — Posted on 2025-05-27
719 Rhythmic sampling of multiple decision alternatives in the human brain
Siems, M.; Cao, Y.; Tohidi-Moghaddam, M.; Donner, T. H.; Tsetsos, K.
10.1101/2023.12.08.570734 — neuroscience — Posted on 2025-05-27
724 Primitive Molecular Buffering by Low-Multivalency Coacervates
Choi, S.; Liu, S.; Meyer, M. O.; Bevilacqua, P. C.; Keating, C. D.
10.1101/2025.05.22.655649 — biophysics — Posted on 2025-05-27
730 ATAD2 mediates chromatin-bound histone chaperone turnover
Liakopoulou, A.; Boussouar, F.; Perazza, D.; Barral, S.; Lambert, E.; Wang, T.; Chuffart, F.; Bourova-Flin, E.; Gard, C.; Puthier, D.; Rousseaux, S.; Arnoult, C.; Verdel, A.; Khochbin, S.
10.1101/2024.10.04.616609 — developmental biology — Posted on 2025-05-27
732 Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial
Lin, X.; Cottrell, C. A.; Kalyuzhniy, O.; Tingle, R.; Kubitz, M.; Lu, D.; Yuan, M.; Schief, W. R.; Wilson, I. A.
10.1101/2025.05.22.655646 — immunology — Posted on 2025-05-27
733 Edible Bird's Nest Enhances Memory and Learning in a Rat Model of Sporadic Alzheimer's Disease
Ibrahim, N. H.; Yahaya, M. F.; Teoh, S. L.; Mohamed, W.; Hui, C. K.; Ugusman, A.; Kumar, J.
10.1101/2025.05.22.655527 — neuroscience — Posted on 2025-05-27
735 Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.
Ricos, M. G.; Cole, B. A.; Hussain, R.; Rychkov, G. G.; Shaukat, Z.; Pilati, N.; Muench, S. P.; Simmons, K. J.; Dibbens, L. M.; Lippiat, J. D.
10.1101/2025.05.22.655336 — pharmacology and toxicology — Posted on 2025-05-27
736 Cellular Senescence Affects ECM Regulation in COPD Lung Tissue
Woldhuis, R. R.; Bekker, N. J.; Nijnatten, J. L. L.; Banchero, M.; Kooistra, W.; Wolters, K. J. C.; Horvatovich, P. L.; Guryev, V.; van den Berge, M.; Timens, W.; Brandsma, C.-A.
10.1101/2023.08.02.551614 — pathology — Posted on 2025-05-27
740 Direct observation of single intrinsically disordered proteins in solution
Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.
10.1101/2025.05.26.656162 — biophysics — Posted on 2025-05-27
742 The RNA splicing factor PRPF8 is required for left-right organiser cilia function and determination of cardiac left-right asymmetry via regulation of Arl13b splicing
Jiang, F.; Boylan, M.; Maxwell, D. W.; Qureshi, W. M. S.; Rowlands, C. F.; Tenin, G.; Mitchell, K.; Stephen, L. A.; Vasconcelos, E. J.; Wang, D.; Chen, T.; Zha, J.; Liu, J.; Althali, N.; Leordean, D. V.; Gallagher, M. T.; Basu, B.; Szymanska, K.; Veeraghanta, A.; Keavney, B.; Humphries, M. J.; Ellingford, J. M.; Smith, D.; Johnson, C. A.; O'Keefe, R. A.; Roy, S.; Hentges, K. E.
10.1101/2025.05.22.654869 — developmental biology — Posted on 2025-05-27
743 Insulin-like peptide secretion is mediated by peroxisome-Golgi interplay
König, M. A.; Kucharowski, N.; Ramos, D. P. D.; Soyka, H.; Wunderling, K.; Bülow, T. R.; Yaghmour, M. H.; Thiele, C.; Ache, J. M.; Kuerschner, L.; Bülow, M. H.
10.1101/2025.05.26.656179 — cell biology — Posted on 2025-05-27
746 Accurate detection of pathogenic structural variants guided by multi-platform comparison
Alavi, N.; Moeinzadeh, M.-H.; Hertzberg, J.; Souto Melo, U.; Ward Al Raei, L.; Infantino, P.; Ghareghani, M.; Savarese, M.; Mundlos, S.; Vingron, M.
10.1101/2025.05.21.655285 — bioinformatics — Posted on 2025-05-27
747 Graphical and Interactive Spatial Proteomics Image Analysis Workflow
Singh, P.; Wright, J. H.; Smythe, K. S.; Fukuda, B. N.; Hung, L.-H.; Yeung, C. C.; Yeung, K. Y.
10.1101/2025.05.23.655879 — bioinformatics — Posted on 2025-05-27
750 Novel Highly Pathogenic Avian Influenza (A)H5N1 Triple Reassortant in Argentina, 2025
Vanstreels, R. E. V.; Nelson, M. I.; Artuso, M. C.; Piccini, L. E.; Marchione, V. D.; Benedetti, E.; Crespo-Bellido, A.; Pierdomenico, A.; Wolff, T.; Uhart, M.; Rimondi, A.
10.1101/2025.05.23.655175 — genomics — Posted on 2025-05-27
752 Parasitoids reduce growth rate in oak-feeding caterpillars
Molleman, F.; Tambay, A.; Mallick, S.; Llopis, S.; Prinzing, A.; Walczak, U.
10.1101/2025.05.23.655719 — ecology — Posted on 2025-05-27
753 Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy
Hasson, J. M.; Katusiime, M. G.; Capoferri, A. A.; Bale, M. J.; Luke, B. T.; Shao, W.; Cotton, M. F.; Van Zyl, G.; Patro, S. C.; Kearney, M. F.
10.1101/2025.05.23.655786 — microbiology — Posted on 2025-05-27
759 Dual roles of Drosophila reward-encoding dopamine neurons in regulating innate and learned behaviors
Lozada-Perdomo, F. V.; Chen, Y.; Jacobs, R. V.; Yeo, J.; Yang, M.; Bhalerao, J.; Devineni, A. V.
10.1101/2025.05.26.656192 — neuroscience — Posted on 2025-05-27
761 Cell Density and mRNA Expression of Inhibitory Interneurons in Schizophrenia: A Meta-Analysis
Mulvey, A. G.; Gabhart, K. M.; Grent-T-Jong, T.; Herculano-Houzel, S.; Uhlhaas, P. J.; Bastos, A. M.
10.1101/2025.05.23.655812 — neuroscience — Posted on 2025-05-27
763 Rising together: Exploring Sourdough Fermentation Diversity through Co-design in the HealthFerm Citizen Science Initiative
Meyer, A. R.; Gettemans, T.; Tan, J. P.; Tucillo, F.; Viretto, C.; Angelescu, I.-R.; De Bondt, Y.; Neugebauer, M.; Zein Alabiden Tlais, A.; Cavelti, F.; De Vuyst, L.; Gobbetti, M.; Courtin, C. M.; Zamfir, M.; Coda, R.; Nystroem, L.; Weckx, S.; Bokulich, N. A.
10.1101/2025.05.23.655785 — scientific communication and education — Posted on 2025-05-27
764 Harnessing distinct tissue-resident immune niches via S100A9/TLR4 improves ketone, lipid, and glucose metabolism
Lucibello, G.; Ursino, G.; Teixeira, P. D. S.; Zahoran, S.; Fanuele, F.; Kallikourdis, M.; Visentin, F.; Veyrat-Durebex, C.; Widmer, A.; Wu, Y.; Cremonesi, M.; Wollheim, C. B.; Castets, P.; Ramadori, G.; Coppari, R.
10.1101/2025.05.21.655283 — physiology — Posted on 2025-05-27
768 Influence of ionic liquids on enzymatic asymmetric carboligations
Gerhards, T.; El Harrar, T.; Klein, A. S.; von Lieres, E.; Paul, C. E.; Lavandera, I.; Gotor-Fernandez, V.; Pietruszka, J.; Pohl, M.; Gohlke, H.; Rother, D.
10.1101/2025.05.21.655364 — bioengineering — Posted on 2025-05-27
769 Controlled delivery of immunomodulatory factors for mineralized tissue formation in an inflammatory microenvironment
Griffin, K. H.; Sagheb, I. S.; Coonan, T. P.; Wu, L. A.; Rowland, D. J.; Arzi, B.; Lewis, J.; Leach, K.
10.1101/2025.05.21.655332 — bioengineering — Posted on 2025-05-27
770 A Novel Human Distal Tubuloid-On-A-Chip Model For Investigating Sodium And Water Transport Mechanisms
Dorileo Leite Bernardi, M. D. L.; Dilmen, E.; Kurek, D.; Lanz, H.; Joore, J.; Hoenderop, J.; Rookmaaker, M. B.; Verhaar, M. C.
10.1101/2025.03.27.644139 — bioengineering — Posted on 2025-05-27
771 Molecular mechanism of substrate transport by human peroxisomal ABCD3
Gupta, M.; Khandelwal, N. K.; Seka, D. J.; Balasubramani, S. G.; Dickinson, M. S.; Myasnikov, A.; Echeverria, I.; Stroud, R. M.
10.1101/2025.05.21.655323 — biochemistry — Posted on 2025-05-27
772 A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway
Steiner, W. P.; Iverson, N.; Liu, G.; Venkatakrishnan, V.; Wu, J.; Stepniewski, T. M.; Michaelson, Z.; Broeckel, J.; Zhu, J.-F.; Bruystens, J.; Lee, A.; Nelson, I.; Bertinetti, D.; Arveseth, C. D.; Tan, G.; Spaltenstein, P.; Xu, J.; Huttenhain, R.; Kay, M.; Herberg, F. W.; Selent, J.; Anand, G. S.; Dunbrack, R. L.; Taylor, S. S.; Myers, B. R.
10.1101/2024.10.31.621410 — biochemistry — Posted on 2025-05-27
773 The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin
Carlson, E. S.; Haslecker, R.; Lecchi, C.; Ramos, M. A.; Vennelakanti, V.; Honaker, L.; Stornetta, A.; Millan, E. S.; Johnson, B. A.; Kulik, H. J.; Balbo, S.; Villalta, P. W.; D'Souza, V.; Balskus, E. P.
10.1101/2025.05.26.655968 — biochemistry — Posted on 2025-05-27
774 On the Stability of Silicone-Encapsulated CMOS ICs for Active Implantable Devices: 4.3 Years of Accelerated Life Testing
Shah Idil, A.; Lamont, C.; Nanbakhsh, K.; Mazza, F.; Giagka, V.; Constandinou, T.; Vanhoestenberghe, A.; Donaldson, N.
10.1101/2025.05.21.655306 — biochemistry — Posted on 2025-05-27
776 Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomics
Shetty, A. C.; Verma, A.; Sivinski, J.; Fan, X.; Doty, C.; Hollander, B.; Roche, D.; Seneviratne, C.
10.1101/2025.05.21.655347 — genomics — Posted on 2025-05-27
778 Ancient and recent riverine gene flow contributed to the adaptive radiation of sailfin silversides in Wallace's Dreampond
De Keyzer, E. L. R.; Herder, F.; Boehne, A.; Campuzano Jimenez, F.; Burskaia, V.; Kukowka, S.; Tracey, A.; Denton, A. L.; Oatley, G.; Tree of Life programme, ; Scientific Operations: DNA Pipelines collective, ; Core Informatics collective, ; Mokodongan, D. F.; Wowor, D.; Svardal, H.
10.1101/2025.04.16.648611 — evolutionary biology — Posted on 2025-05-27
780 METTL3 regulates exocytosis independently of m6A
Esteva-Socias, M.; Battharai, D. P.; Achour, C.; Baidya, P.; Fontanari, G.; Seier, K.; Pace, H.; Malla, S.; Zhu, S.; Lundin, E.; Vagbo, C. B.; Bally, M.; Swaminathan, V. S.; Mateus, A.; Rodriguez-Barrueco, R.; Pich, A.; Aguilo, F.
10.1101/2025.05.26.656168 — molecular biology — Posted on 2025-05-27
781 Mechanosensitive Endothelial METTL7A Regulates Internal m7G mRNA Methylation and Protects Against Atherosclerosis
Shentu, T.-P.; Wu, T.; Zhou, Z.; Yeh, C.-F.; Zhu, J.; Li, J.; Miao, B. A.; Lee, T.-H.; Zhang, L.; Huang, R.-T.; Harrison, D.; Hodonsky, C. J.; Auguste, G.; Husain, A.; Tirrell, M. V.; Miller, C. L.; Dickinson, B.; Yang, K.-C.; Fang, Y.
10.1101/2025.05.22.655328 — molecular biology — Posted on 2025-05-27
787 Tracking Persistence and Dynamics of Active Soil Viruses with SIP-Viromics
Trubl, G.; Roux, S.; Kellom, M.; Vyshenska, D.; Tomatsu, A.; Singh, K.; Kimbrel, J.; Eloe-Fadrosh, E. A.; Malmstrom, R. R.; Pett-Ridge, J.; Blazewicz, S. J.
10.1101/2025.05.25.655894 — microbiology — Posted on 2025-05-27
788 Complete genomes of Rickettsia typhi reveal a clonal population
Keeratipusana, C.; Phuklia, W.; Phommadeechack, V.; Thaipadungpanit, J.; Chansamouth, V.; Phommasone, K.; Rattanavong, S.; Moore, C. E.; Robinson, M. T.; Richards, A. L.; Newton, P. N.; Batty, E. M.
10.1101/2025.05.25.654783 — microbiology — Posted on 2025-05-27
789 NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
GLON, D.; Riller, Q.; Riviere, F.; Leonardon, B.; Guillemot, A.; Sago, L.; Pelle, O.; Ho-Nhat, D.; Brochard, K.; Bader-Meunier, B.; Fremond, M.-L.; Lepelley, A.; Crow, Y.; Tusseau, M.; Belot, A.; Lagaudriere-Gesbert, C.; Rieux-Laucat, F.; GAUDIN, Y.
10.1101/2025.05.21.655319 — immunology — Posted on 2025-05-27
790 GABA-induced Ca2+ signaling in the primary cilium of neurons
Sanchez, G.; Sodergren, M.; Maurya, D. K.; Gronbladh, A.; Lindskog, M.; Idevall-Hagren, O.
10.1101/2025.05.26.656109 — neuroscience — Posted on 2025-05-27
795 End Processing in NHEJ by Polymerase {lambda} and PNKP is coordinated during short-range synapsis
Vogt, A.; Kaminski, A. M.; Pedersen, L. C.; Naila, T.; Tomkinson, A. E.; Lees-Miller, S. P.; Kunkel, T. A.; He, Y.
10.1101/2025.05.25.656038 — biophysics — Posted on 2025-05-27
798 SCOT+: A Comprehensive Software Suite for Single-Cell alignment Using Optimal Transport
Baker, C. D.; Pham, T. M.; Demetci, P.; Tran, Q.-H.; Redko, I.; Sandstede, B.; Singh, R.
10.1101/2025.05.21.655322 — bioinformatics — Posted on 2025-05-27
799 DynaRNA: Dynamic RNA Conformation Ensemble Generation with Diffusion Model
Chen, H.; Li, Z.; Zhu, J.; Hong, X.; Zheng, Z.; Cui, T.; Sun, Y.; Wei, T.
10.1101/2025.05.22.655453 — bioinformatics — Posted on 2025-05-27
801 SCALE: Unsupervised Multi-Scale Domain Identification in Spatial Omics Data
Yousefi, B.; Schaub, D. P.; Khatri, R.; Kaiser, N.; Kuehl, M.; Ly, C.; Puelles, V. G.; Huber, T. B.; Prinz, I.; Krebs, C. F.; Panzer, U.; Bonn, S.
10.1101/2025.05.21.653987 — bioinformatics — Posted on 2025-05-27
802 Substrate-induced assembly and functional mechanism of the bacterial membrane protein insertase SecYEG-YidC
Busch, M.; Hernandez, C. R.; Kamel, M.; Schaumkessel, Y.; van der Sluis, E.; Berninghausen, O.; Becker, T.; Beckmann, R.; Kedrov, A.
10.1101/2025.05.26.656142 — biochemistry — Posted on 2025-05-27
803 Mechanism of activation of an ancestral Tec kinase by PIP3
Krötenheerdt, E.; von Raussendorf, F.; Reinhardt, R.; Piëch, L.; Wedige, N.; Nyvall, H. G.; Burke, J. E.; Leonard, T. A.
10.1101/2025.05.22.653117 — biochemistry — Posted on 2025-05-27
804 Perturbation of epithelial and limbal stem cell identity in a mouse model of pathologic corneal neovascularization
Abbasi, M.; Arts, J. A.; Javidjam, S.; Moustardas, P.; Dashti, A.; Aberdam, D.; Zhou, H.; Lagali, N.
10.1101/2025.05.22.655502 — molecular biology — Posted on 2025-05-27
811 Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions
El Kadri, M.; Guegan, F.; Sharma, P.; Calvo Alvarez, E.; Pineda, E.; Morand, P.; Ngoune, J. M.; Escard, J.; Dupuy, J.-W.; Rimoldi, A.; Plazolles, N.; Biran, M.; Barrett, M. P.; Figueiredo, L. M.; Rotureau, B.; Bringaud, F.
10.1101/2025.05.26.656071 — microbiology — Posted on 2025-05-26
814 Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol.
GSCHWIND, R.; Bonnet, M.; Abramova, A.; Jarquin Diaz, V. H.; Wenne, M.; Loeber, U.; Godron, N.; Kampouris, I. D.; Tskhay, F.; Naheed, F.; Debroucker, C.; Bui-Hai, M.; El Aiba, I.; Klumper, U.; Berendonk, T. U.; Forslund-Startceva, S. K.; Zahra, R.; Bengtsson-Palme, J.; RUPPE, E.
10.1101/2025.05.26.656069 — microbiology — Posted on 2025-05-26
815 Widespread and Abundant CRISPR-Cas Systems in the Deep Ocean
Sanchez, P.; Ferri-Peradalta, M.; Garcia, E. M. L.; Ruiz, R.; Ruvira, B. E.; Gasol, J. M.; Vaque, D.; Gojobori, T.; Agusti, S. R.; Duarte, C. M.; Mojica, F. J.; Ceron, J.; Coutinho, F. H.; Acinas, S. G.
10.1101/2025.05.26.656144 — microbiology — Posted on 2025-05-26
817 Expansion, functional diversification and gene fusion events in the Ato protein family
Ghasemi, F.; Antunes, C. B.; Pyrris, Y.; Ataide, P.; Alves, J.; Fernandes, V.; Alves, R.; Goncalves, A. G.; Casal, M.; Van Genechten, W.; Nysten, J.; Brown, A. J. P.; Van Dijck, P.; Diallinas, G.; Pittis, A. A.; Soares-Silva, I.; Paiva, S.
10.1101/2025.05.26.656167 — microbiology — Posted on 2025-05-26
820 Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity
Weight, C. M.; Pollara, G. M.; Betts, M.; Ragazzini, R.; Connor, M.; Ramos-Sevillano, E.; Reine, J.; Whelan, M.; Guerra-Assuncao, J. A.; Bonfanti, P.; Jolly, C.; Noursadeghi, M.; Ferreira, D.; Brown, J.; Heyderman, R. S.
10.1101/2023.06.15.545009 — microbiology — Posted on 2025-05-26
822 Multidirectional alignment of collagen fibers to guide cell orientation in 3D-printed tissue
Singhal, D.; Christakopoulos, F.; Brunel, L. G.; Borkar, S.; Doulames, V. M.; Myung, D.; Fuller, G. G.; Heilshorn, S. C.
10.1101/2025.05.20.654730 — bioengineering — Posted on 2025-05-26
829 Persistent nitrogenase isotope signatures over two billion years of engineered evolution
Rucker, H.; Bubphamanee, K.; Harris, D.; Konhauser, K.; Seefeldt, L.; Buick, R.; Kacar, B.
10.1101/2025.05.21.655380 — evolutionary biology — Posted on 2025-05-26
832 Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma
Coley, A. K.; Nawrocki, C.; Patel, B. K.; Pankaj, A.; Guo, Z.; Emmett, M. J.; Lang, E. R.; Song, Y.; Xu, K. H.; Ferrone, C. R.; Deshpande, V.; Nieman, L. T.; Aryee, M.; Franses, J. W.; Ting, D. T.
10.1101/2023.12.04.570014 — cancer biology — Posted on 2025-05-26
834 A protein-DNA surface hydrogel mechanically protects the cell nucleus
Adakkattil, R.; Mandal, P.; Savich, Y.; Ruffine, V.; Jordan, M. A.; Pinholt, H. D.; Fischer-Friedrich, E.; Julicher, F.; Grill, S. W.; Von Appen, A.
10.1101/2025.05.21.655270 — biophysics — Posted on 2025-05-26
836 TypeSINE: Genome-Wide Detection of SINE Retrotransposon Polymorphisms Reveals Functional Variants Linked to Body Size Variation in Pigs
Zheng, Y.; Yang, N.; Chen, C.; Zong, W.; Chen, H.; Shi, S.; Wang, X.; Murani, E.; Reyer, H.; Gao, B.; Zhang, L.; Wimmers, K.; Song, C.
10.1101/2025.05.21.653756 — bioinformatics — Posted on 2025-05-26
837 Empirical validation of ephaptic coupling in printed human neural circuits
Striebel, J.; Habibey, R.; Wendland, D.; Gehring, H.; Podoliak, E.; Pawlick, J. S.; Sharma, K.; Ng, A. H. M.; Pernice, W.; Busskamp, V.
10.1101/2025.05.21.655141 — bioengineering — Posted on 2025-05-26
839 aDISCO: A Broadly Applicable Method for 3D Microscopy of Archival Paraffin-Embedded Human Tissues
Reuss, A. M.; Rupprecht, P.; Groos, D.; Cerisoli, M.; Nordberg, L.; Frick, L.; Voigt, F.; Vladimirov, N.; Bethge, P.; Reimann, R.; Helmchen, F.; Aguzzi, A.
10.1101/2025.05.21.655358 — bioengineering — Posted on 2025-05-26
841 Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing
Trotman, J. B.; Porrello, A.; Schactler, S. A.; DeLeon, L. E.; Eberhard, Q. E.; Boyson, S. P.; Zhang, Z.; Lee, D. M.; Kirik, S. E.; Nguyen, S. N.; Beltejar, M.-C. G.; Shinn, M. K.; Ong, S.-E.; Gonzalez-Perez, M. P.; Shaffer, S. A.; Dominguez, D.; Shechner, D. M.; Calabrese, M.
10.1101/2025.05.21.655143 — genetics — Posted on 2025-05-26
850 Malaria parasite population genomics during an elimination program in Eastern Myanmar
Li, X.; Arya, G.; Thu, A. M.; Landier, J.; Parker, D.; Delmas, G.; Reyes, A.; Lwin, K. M.; Sriprawat, K.; Nosten, F.; Anderson, T. J.
10.1101/2025.05.21.655408 — genomics — Posted on 2025-05-26
853 Amazon biodiversity is at risk from metal contamination due to mining activity
Moulatlet, G. M.; Capparelli, M.; Thomas, C.; Boyle, B.; Feng, X.; Frazier, A.; Hinojo-Hinojo, C.; Herrera, J.; Nahomi, L.; Lechner, A.; Maitner, B.; Newman, E.; Nikolopoulos, E.; Roehrdanz, P.; Song, L.; Valencia-Rodriguez, D.; Yang, W.; Merow, C.; Silman, M.; VIllalobos, F.; Macklin, M.; Enquist, B. J.
10.1101/2025.05.21.654597 — ecology — Posted on 2025-05-26
855 Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington's disease
Baffuto, M.; Mätlik, K.; Ilyashov, I.; Siantoputri, M. E.; Chetia, H.; Harada, Y.; Sipos, E.; Darnell, P.; Kus, L.; Carroll, T.; Barrows, D.; Pressl, C.; Didkovsky, N.; Heintz, N.
10.1101/2025.05.21.653721 — neuroscience — Posted on 2025-05-26
856 MRI mapping of hemodynamics in the human spinal cord
Hemmerling, K. J.; Hoggarth, M. A.; Sandhu, M. S.; Parrish, T. B.; Bright, M. G.
10.1101/2024.02.22.581606 — physiology — Posted on 2025-05-26
857 Quantification of HER2-low and ultra-low expression in breast cancer specimens by quantitative IHC and artificial intelligence
Aidt, F.; Arbel, E.; Remer, I.; Ben-David, O.; Ben-Dor, A.; Rabkin, D.; Hoff, K.; Salomon, K.; Aviel-Ronen, S.; Nielsen, G.; Mollerup, J.; Jacobsen, L.; Tsalenko, A.
10.1101/2025.01.22.634230 — pathology — Posted on 2025-05-26
862 tUbe net: a generalisable deep learning tool for 3D vessel segmentation
Holroyd, N. A.; Li, Z.; Walsh, C.; Brown, E. E.; Shipley, R. J.; Walker-Samuel, S.
10.1101/2023.07.24.550334 — microbiology — Posted on 2025-05-26
864 Mechanism of bridge-type phospholipid transfer by Atg2 for autophagosome biogenesis
Sakai, Y.; Matoba, K.; Kotani, T.; Hao, L.; Suzuki, K.; Kakuta, C.; Sugita, Y.; Osawa, T.; Nakatogawa, H.; Noda, N. N.
10.1101/2025.05.24.655882 — cell biology — Posted on 2025-05-26
865 Efficient installation of heterozygous mutations in human pluripotent stem cells using prime editing
Suter, A.; Graham, A.; Kuah, J. Y.; Crisologo, J.; Gunatilake, C.; Sourris, K.; See, M.; Rossello, F. J.; Ramialison, M.; Vlahos, K.; Howden, S. E.
10.1101/2025.05.25.656043 — cell biology — Posted on 2025-05-26
868 On the Curvature and Relaxation of Microtubule Plus-endTips
Skora, T.; Wu, J.; Beckett, D.; Xue, W.; Voth, G. A.; Bidone, T. C.
10.1101/2025.05.23.655844 — biophysics — Posted on 2025-05-26
869 Cryo-EM reveals open and closed Asgard chromatin assemblies
Ranawat, H. M.; Cajili, M. K. M.; Lopez-Barbosa, N.; Quail, T.; Dame, R. T.; Dodonova, S. O.
10.1101/2025.05.24.653377 — biophysics — Posted on 2025-05-26
870 Medical Images as Biomarkers of Ageing - From Global and Local Patterns to Digital Twins
Mueller, T. T.; Starck, S.; Llalloshi, R.; Kaissis, G.; Ziller, A.; Rueckert, D.; Braren, R.
10.1101/2025.05.18.654705 — bioinformatics — Posted on 2025-05-26
872 The biogeography of evolutionary radiations on oceanic archipelagos
Bree, B.; Matthews, T. J.; Fernandez-Palacios, J. M.; Paroissin, C.; Triantis, K. A.; Whittaker, R. J.; Rigal, F.
10.1101/2024.10.07.616413 — evolutionary biology — Posted on 2025-05-26
874 Mitochondria at synapse utilize fatty acids as a bioenergetic fuel source
Antunes, B. C.; Faria-Pereira, A.; Goncalves Ribeiro, J.; Costa Pinto, S.; Vaz, S. H. A.; Morais, V. A.
10.1101/2025.05.26.656116 — cell biology — Posted on 2025-05-26
875 TRPV4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm's canal cells
Li, H.; Wong, C. A.; Siadat, S. M.; Perkumas, K. M.; Bertrand, J. A.; Overby, D. R.; Sulchek, T.; Stamer, W. D.; Ethier, C. R.
10.1101/2025.05.25.656000 — cell biology — Posted on 2025-05-26
876 Multiplexed Targeted Spatial Mass Spectrometry Imaging Assays to monitor lipids and NAD+ metabolites in CD38 knockout mice exhibiting improved metabolism.
Schurman, C. A.; Bons, J.; Kumaar, P. V.; Fang, J.; Hormazabal, G. V.; Roberts, A.; Riley, R. R.; Tao, N.; Verdin, E.; Schilling, B.
10.1101/2025.05.25.655991 — cell biology — Posted on 2025-05-26
881 Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence
Rios, M. S.; Ripoll-Cladellas, A.; Omidi, F.; Ballouz, S.; Alquicira-Hernandez, J.; Oelen, R.; Franke, L.; van der Wijst, M. G. P.; Powell, J. E.; Mele, M.
10.1101/2024.11.06.622096 — bioinformatics — Posted on 2025-05-26
883 Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model
Welz, B.; Pierotti, S.; Fitzgerald, T. W.; Thumberger, T.; Suzuki, R.; Watson, P.; Fuss, J.; Cordeiro da Trindade, T.; Defranoux, F.; Ferreira, M.; Naruse, K.; Loosli, F.; Gierten, J.; Wittbrodt, J.; Birney, E.
10.1101/2025.04.24.650462 — genetics — Posted on 2025-05-26
887 Antibiotic perturbation of the human gut phageome preserves its individuality and promotes blooms of virulent phages.
Pfeifer, E.; Humieres, C.; Lamy-Besnier, Q.; Plaza-Onate, F.; Denise, R.; Dion, S.; Condamine, B.; Touchon, M.; Ma, L.; Burdet, C.; Mentre, F.; Denamur, E.; Rocha, E.
10.1101/2025.02.07.636470 — microbiology — Posted on 2025-05-26
898 Synchronous Miocene radiations and geographic-dependent diversification of pantropical Xylopia (Annonaceae)
Nge, F. J.; Johnson, D. M.; Murray, N. A.; Holzmeyer, L.; Floyd, K.; Stull, G.; Soule, V.; Sepulchre, P.; Tardif, D.; Rodrigues Vaz, C.
10.1101/2025.05.21.655441 — evolutionary biology — Posted on 2025-05-26
899 Impact of Group Size and Habitat Disturbance on Parasitic Infection in Free-ranging Proboscis Monkeys
Fitri-Suhaimi, M. N.; Frias, L.; Zimmermann, E.; Lambut, P.; Tangah, J.; Bernard, H.; Subbiah, V. K.; Matsuda, I.
10.1101/2025.05.21.655443 — ecology — Posted on 2025-05-26
900 The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.
Magalhaes Pinto, M.; Malengier-Devlies, B.; Seuzaret, G.; Ahlback, A.; Becker, S.; Patatsos, K.; Drakoulis, G.; Karjalainen, J.; Ruedl, C.; Voehringer, D.; Bain, C.; Emmerson, E.; Schonfeldova, B.; Zec, K.; Udalova, I. A.; Simakou, T.; MacDonald, L.; Kurowska-Stolarska, M.; Miotla-Zarebska, J.; Vincent, T.; Ricci, R.; Erbs, E.; Barrington, J.; McColl, B.; Neag, G.; Kemble, S.; Mahony, C.; Croft, A.; Boon, L.; Migotsky, N.; Killian, M.; Brahim, O. B.; Uderhardt, S.; Gallerand, A.; IVANOV, S.; Gentek, R.
10.1101/2025.05.21.655269 — immunology — Posted on 2025-05-26
901 Non-destructive, high-resolution T cell characterization and subtyping via deep-ultraviolet microscopy
Gorti, V.; Serafini, C. E.; Silva Trenkle, A. D.; McCubbins, K.; LeCompte, I.; Kwong, G. A.; Robles, F. E.
10.1101/2025.05.20.655120 — immunology — Posted on 2025-05-26
902 Noninvasive focal gene transfer of chemogenetic proteins in the primate brain
Corigliano, M. R.; Parks, T. V.; Guretse, S. S.; Letica, L.; Zimmermann Rollin, I.; Pell, S. K. A.; Campos, V. P.; Szczupak, D.; Schaeffer, D. J.
10.1101/2025.05.21.655304 — neuroscience — Posted on 2025-05-26
903 Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation
Zhu, C.; Lucero, E.; Patel, R.; Makita, T.; Wang, J. J.; Cao, Y.; Rockman, H. A.; Shivkumar, K.
10.1101/2025.05.20.655085 — physiology — Posted on 2025-05-26
904 Honeybees collect pollen from the buzz-pollinated flowers of invasive Solanum elaeagnifolium in Northern Greece
Kantsa, A.; Nakas, G.; Kariyat, R. R.; Lambert, H.; Petanidou, T.; De Moraes, C. M.; Mescher, M. C.
10.1101/2025.05.13.648936 — ecology — Posted on 2025-05-26
906 Changes in the Public IgM Repertoire and Its Idiotypic Connectivity in Alzheimer's Disease and Frontotemporal Dementia
Pashova-Dimov, S.; Petrov, P.; Karachanak-Yankova, S.; Belezhanska, D.; Zhelev, Y.; Mehrabian, S.; Traykov, L.; Toncheva, D.; Pashov, A.
10.1101/2024.07.15.603559 — immunology — Posted on 2025-05-26
913 Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria
Gao, Y.; Fang, C.; Zhou, B.; Hameed, H. M. A.; Sun, C.; Tian, X.; He, J.; Han, X.; Zhang, H.; Li, J.; Ju, J.; Chen, X.; Zhong, N.; Ma, J.; Xiong, X.; Zhang, T.
10.1101/2024.02.24.581832 — microbiology — Posted on 2025-05-26
914 Faroese Whole Genomes Provide Insight into Ancestry and Recent Selection
Hamid, I.; Mortensen, O.; Refoyo-Martinez, A.; Lydersen, L. N.; Emde, A.-K.; Hendershott, M.; Apol, K. D.; Andorsdottir, G.; Meisner, J.; Wasik, K. A.; Racimo, F.; Castel, S. E.; Gregersen, N. O.
10.1101/2025.05.20.655212 — genetics — Posted on 2025-05-26
915 Host usage in Aedes aegypti collected from Houston, Texas and Phoenix, Arizona using whole mosquito third-generation sequencing blood meal analysis
Ciomperlik, B. A.; Burgess, E. R.; Sanscrainte, N. D.; Mosore, M.-t.; Townsend, J.; Will, J.; Busser, N.; Estep, A.
10.1101/2025.05.19.654806 — ecology — Posted on 2025-05-26
917 IL-17A-driven Macrophage Disorder Promotes Plaque Instability in Psoriatic Atherosclerosis
Dong, C.; Wang, J.; Lin, J.-M.; Lu, X.; Zhu, J.; Lin, L.; Zhou, L.; Liu, F.; Wu, D.; Zhu, X.; Sun, J.; Xu, J.; Zhu, N.; Wu, W.; Tan, J.; Du, J.
10.1101/2025.05.21.654491 — cell biology — Posted on 2025-05-26
918 Mapping early patterning events in human neural development usingan in-vitro microfluidic stem cell model
Rathore, G. S.; Ankjaer, M.; Rifes, P.; Hanninen, E.; Calleja, F. S.; Rusimbi, C.; Kajtez, J.; Nygaard, A. H.; Piilgaard, L. S.; Dubonyte, U.; Norgaard, Z. A.; Christensen, J. B.; Egerod, K. L.; Camp, J. G.; Pers, T.; Treutlein, B.; Kirkeby, A.
10.1101/2025.05.23.655442 — neuroscience — Posted on 2025-05-26
919 Large protein databases reveal structural complementarity and functional locality
Szczerbiak, P.; Szydlowski, L. M.; Wydmanski, W.; Renfrew, P. D.; Koehler Leman, J.; Kosciolek, T.
10.1101/2024.08.14.607935 — bioinformatics — Posted on 2025-05-26
920 Phylogenomic evidence for host specialization and genetic divergence in OsHV-1 infecting Magallana gigas and Ostrea edulis
Pelletier, C.; Chevignon, G.; Faury, N.; Arzul, I.; Garcia, C.; Chollet, B.; Renault, T.; Morga, B.; Jacquot, M.
10.1101/2023.08.23.554398 — evolutionary biology — Posted on 2025-05-26
922 KIF5B and Dynein regulate adhesion-dependent Golgi organization and microtubule acetylation
Chakraborty, A.; Pitke, S.; BR, R.; Buwa, N.; Dasgupta, A.; Behera, R.; Jayakrishnan, M.; Balasubramanian, N.
10.1101/2025.05.11.653231 — cell biology — Posted on 2025-05-26
924 Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onward
Dupas, M.-C.; Vincenti-Gonzalez, M. F.; Dhingra, M.; Guinat, C.; Vergne, T.; Wint, G. W.; Hendrickx, G.; Marsboom, C.; Gilbert, M.; Dellicour, S.
10.1101/2024.11.15.623755 — ecology — Posted on 2025-05-25
927 Task-relevant cognitive maps in episodic memory
Rau, E. M. B.; Heinen, R.; Herweg, N. A.; Patai, E. Z.; Kobelt, M.; Ahmadi, K.; Axmacher, N.
10.1101/2025.05.23.655754 — neuroscience — Posted on 2025-05-25
928 Age and Alzheimer's disease affect functional connectivity along separate axes of functional brain organization
Rittmo, J.; Franzmeier, N.; Strandberg, O.; Chauveau, L.; Satterthwaite, T. D.; Wisse, L. E.; Spotorno, N.; Behjat, H. H.; Dehsarvi, A.; van Westen, D.; Anijärv, T. E.; Palmqvist, S.; Janelidze, S.; Stomrud, E.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Hansson, O.; Vogel, J. W.
10.1101/2025.05.22.655469 — neuroscience — Posted on 2025-05-25
933 Engineering of interconnected microcapillary networks at the mesoscale via magnetic assembly of endothelial-cell 'seeds'.
Rojek, K.; Wrzos, A.; Maiullari, F.; Gizynski, K.; Ceraolo, M. G.; Bearzi, C.; Rizzi, R.; Szymczak, P.; Guzowski, J.
10.1101/2025.05.20.655072 — bioengineering — Posted on 2025-05-25
934 Multidirectional alignment of collagen fibers to guide cell orientation in 3D-printed tissue
Singhal, D.; Christakopoulos, F.; Brunel, L. G.; Borkar, S.; Doulames, V. M.; Myung, D.; Fuller, G. G.; Heilshorn, S. C.
10.1101/2025.05.20.654730 — bioengineering — Posted on 2025-05-25
938 A spatially targeted metric of potential koala populations based on Bayesian Networks for conservation management
Muriuki, G.; Mooney, S.; Castiglione, M.; Davis, J.; Pitchforth, J.; Johnson, S.; Duwalage, K. I.; Mengersen, K.; Wu, P. P.-Y.
10.1101/2025.05.20.655061 — ecology — Posted on 2025-05-25
939 The landscape and consequences of transcription stress
Aqeilan, R. I.; Hidmi, O.; Oster Flayshman, S.; Shatleh, D.; Monin, J.
10.1101/2025.05.25.655982 — molecular biology — Posted on 2025-05-25
940 CAMK2D causes heart failure in RBM20 cardiomyopathy
van den Hoogenhof, M. M.; Duran, J.; Britto-Borges, T.; Kemmling, E.; Konrad, L.; Lennermann, D. C.; Hartmann, J.; Schraft, L.; Kornienko, J.; Bock, T.; Krueger, M.; Dieterich, C.; Steinmetz, L. M.; Dewenter, M.; Backs, J.
10.1101/2025.05.23.655557 — molecular biology — Posted on 2025-05-25
941 Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Lansink, L. I. M.; Walther, L.; Longmore, S.; Jones, M.; Dowle, A.; Faria, J. R.
10.1101/2025.05.24.654301 — molecular biology — Posted on 2025-05-25
948 Unravelling the constrained cell growth in engineered living materials
Sun, S.-S.; Ding, C.-C.; Yu, H.-Y.; Yuan, X.-Z.; Wang, S.-G.; Xia, P.-F.
10.1101/2025.05.21.655284 — bioengineering — Posted on 2025-05-25
949 Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras
Maiocchi, A.; Abel, A.-C.; Basellini, M.; Perez-Pena, H.; Boiarska, Z.; Ferrandi, E. E.; Kozicka, Z.; Fasano, V.; Pieraccini, S.; Cappelletti, G.; Steinmetz, M. O.; Passarella, D.; Prota, A. E.
10.1101/2025.05.22.655572 — biochemistry — Posted on 2025-05-25
951 Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5
Goetzke, F. W.; Bernard, S. M.; Ju, C.-W.; Pollock, J.; DeMeester, K. E.; Gross, J.; Simon, G. M.; He, C.; Melillo, B.; Cravatt, B. F.
10.1101/2025.05.25.655995 — biochemistry — Posted on 2025-05-25
952 Unmasking Human T Cell Receptor Germline Diversity: 335 Novel Alleles Identified in 47 Pangenome Reference Individuals Using the gAIRR Suite
Yang, Y.-H.; Yao, C.-Y.; Lin, M.-J.; Huang, K.-T.; Lin, Y.-H.; Chiu, I.-H. C.; Lai, S.-K.; Chen, C.-Y.; Yang, Y.-C.; Hsu, C.-L.; Hsu, J. S.; Chen, C.-Y.; Chen, P.-L.
10.1101/2025.05.24.655452 — genomics — Posted on 2025-05-25
955 Evolutionary responses to historic drought across the range of scarlet monkeyflower
Sheth, S. N.; Albano, L. J.; Blanchard, C.; Cook, E. J.; Diaz, R.; Gomez-Vega, X.; Kutella, K.; Moazed, M.; Patel, M.; Prange, J.; Ramadoss, N.; Regan, A.; Riley, A.; Rivas Hernandez, M.; Rojas, J.; Strebler, M.; Verma, A.; Villano, L.; Waits, J.; Wang, D.; Wilborn-Pilotte, O.; Diez, J.; Flores-Renteria, L.; Sexton, J.; Muir, C. D.
10.1101/2025.05.20.655098 — evolutionary biology — Posted on 2025-05-25
956 Escaping inbreeding: the demographic path to genetic recovery
Ahrens, C. W.; Miller, A. D.; Silver, L. W.; Mclennan, E. A.; Hogg, C. J.; Weeks, A. R.
10.1101/2025.05.20.655063 — evolutionary biology — Posted on 2025-05-25
958 Diverse behavioural responses of vampire bats to human disturbance revealed by state-space modelling of sparse GPS data.
Cardoso Ribeiro, R. C.; Zariquiey, C. M.; Chavez, W.; Pillaca Rodriguez, K.; Clavijo Manuttupa, J.; Risco Huiman, M. A.; Zuniga Villafuerte, R.; Campana Quintanilla, W.; Medrano-Uchuya, N.; French, H.; Czyzewski, J.; Shiva, C.; Falcon, N.; Valderrama, W.; Walsh, D. P.; Rocke, T. E.; Matthiopoulos, J.; Streicker, D. G.
10.1101/2025.05.20.655023 — ecology — Posted on 2025-05-25
959 Creatine synthesis is a tumor suppressor pathway hypostatic to one-carbon metabolism
Leung, N. Y. T.; Yee, T. M.; AminiTabrizi, R.; Bhalla, R.; Ang, N.; Lu, L.; Chan, C. Y.; Lian, D. W. Q.; Lim, M. Y.; Paulo, J. A.; Wu, W.; Shah, H.; Wang, L. W.
10.1101/2025.05.23.655758 — molecular biology — Posted on 2025-05-25
960 Intestinal Stem Cells Retain an Epigenetic Memory of Prior Inflammation
Hamdan, F. H.; Perez, I.; Smith, H.; Kossick, K.; Edwinson, A.; de Hoyos-Vega, J. M.; Gonzalez, M.; Chiang, D.; Klatt, E.; Rumer, K.; Perez Pachon, M.; Sagstetter, M.; Friton, J.; Kammer, E.; English, A.; Chini, L. C. S.; Carnahan, J. F.; Baca, N. A.; Mopuri, R.; Bhagwate, A.; Raffals, L. E.; Sun, Z.; Grover, M.; Revzin, A.; Faubion, W. A.; Druliner, B. R.
10.1101/2025.05.24.655923 — molecular biology — Posted on 2025-05-25
964 Fat-rich diet reprograms intrapulmonary neutrophils to boost tissue-specific antitumor immunity
Wang, Y.; Zhang, J.; Li, Y.; Wang, T.; Wang, L.; Miao, Y.; Chang, C.-W.; Liu, Y.; Huang, Z.; Yao, Z.; Xu, H.; Zhou, Q. D.; Wang, L.; Yao, Y.
10.1101/2025.05.20.655047 — immunology — Posted on 2025-05-25
969 Siibra: A software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources
Dickscheid, T.; Gui, X.; Simsek, A. N.; Schiffer, C.; Mangin, J.-F.; Leprince, Y.; Jirsa, V.; Bjaalie, J. G.; Leergaard, T. B.; Bludau, S.; Amunts, K.
10.1101/2025.05.20.655042 — bioinformatics — Posted on 2025-05-25
972 SPITROBOT-2 advances time-resolved cryo-trapping crystallography to under 25 ms
Spiliopoulou, M.; Hatton, C. E.; Kollewe, M.; Leimkohl, J.-P.; Schikora, H.; Tellkamp, F.; Mehrabi, P.; Schulz, E. C.
10.1101/2025.05.23.655289 — biochemistry — Posted on 2025-05-25
973 Distinct classes of antidepressants commonly act to shape pallidal structure and function in mice
Abe, Y.; Sugiura, Y.; Maeda, R.; Taira, S.; Yoshida, K.; Ibi, D.; Moritoh, S.; Hashimoto, K.; Yagishita, S.; Tanaka, K. F.
10.1101/2024.09.23.614626 — neuroscience — Posted on 2025-05-25
978 Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation
Wood, C. P.; Shin, Y.; Balaguer, M. G.; Campo, P.; Dirik, S.; Montoya, B. A.; Cook, G. M. R.; Palermo, G. M.; Naghshineh, P. K.; Morgan, A.; Rahman, S. R. M. U.; Palmer, A. A.; Telese, F.; de Guglielmo, G.
10.1101/2025.05.20.655167 — animal behavior and cognition — Posted on 2025-05-25
979 Off-target interaction of the amyloid PET imaging tracer PiB with acetylcholinesterase
Granzotto, A.; Fullone, R.; Miccoli, L.; Bomba, M.; Di Marzio, C.; Delli Pizzi, S.; Floresta, G.; Sensi, S. L.
10.1101/2025.05.16.654428 — neuroscience — Posted on 2025-05-25
981 Genetic background influences the heterogeneous phenotypes driven by the MAFAS64F MODY variant in male mice
Loyd, Z.; Lee, D.; Maurer, M.; Liu, J.-H.; Guo, M.; Reynolds, G.; Magnuson, M. A.; Cartailler, J.-P.; Stein, R.; Cha, J.
10.1101/2025.05.20.653758 — physiology — Posted on 2025-05-25
990 Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice
Zhang, C.; Yang, D.; Suzuki, H.; Chen, J.; Wang, J.; Ye, M.; Zhou, J.; Zeng, Q.; Bai, M.; Lin, M.-J.; Lee, J.; Zhu, H.; Hoshida, Y.; Zeng, X.
10.1101/2025.05.20.655199 — physiology — Posted on 2025-05-25
997 Perivascular matrix densification dysregulates angiogenesis and activates pro-inflammatory endothelial cells
Xia, J.; Wang, W.; Jacobs, K.; Lin, D.; Jarman, E.; Matera, D.; Loesel, K.; Davison, C.; Hiraki, H.; Tan, X.; Shikanov, E.; Kent, R.; Parent, C.; Fan, X.; Shikanov, A.; Kutys, M. L.; Baker, B.
10.1101/2025.05.20.655215 — bioengineering — Posted on 2025-05-25
999 Diffusion Neuroimaging of Speech Acquisition in Infants
Liu, F.; Liu, J.; Gu, J.; Wang, Y.; Cai, X.; Wang, Z.; Wu, H.; Feng, J.; Zhang, H.; Shen, D.
10.1101/2025.05.23.655876 — neuroscience — Posted on 2025-05-25
1003 Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif
Biga, V.; Miller, A.; Kamath, A.; Mak, Y. Q. P.; Adamson, A. D.; Marinopoulou, E.; Francois, P.; Papalopulu, N.; Manning, C. S.
10.1101/2025.05.22.655498 — developmental biology — Posted on 2025-05-24
1004 Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens
Regalado, S. G.; Qiu, C.; Lalanne, J.-B.; Martin, B. K.; Duran, M.; Trapnell, C.; Keith, A.; Domcke, S.; Shendure, J.
10.1101/2025.05.23.655669 — developmental biology — Posted on 2025-05-24
1005 A Forebrain Hub for Cautious Actions via the Midbrain
Zhou, J.; Sajid, M. S.; Hormigo, S.; Castro-Alamancos, M. A.
10.1101/2025.05.24.655906 — neuroscience — Posted on 2025-05-24
1010 RAD51AP1 is a versatile RAD51 modulator
Kuhlen, L.; Argunhan, B.; Liang, P.; Zhong, J.; Masino, L.; Zhang, X.
10.1101/2025.05.24.655746 — biochemistry — Posted on 2025-05-24
1011 A Proteolytic Switch: USP5 controls SDE2 function via UBL-directed cleavage
Hales, L. T.; Tammiste, P. M.; Walker, A. J.; Bryce, R.; Sugden, A.; Knebel, A.; Toth, R.; Lamoliatte, F.; Peteri, M.; Curry, O.; De Cesare, V.; Maniaci, C.
10.1101/2025.05.23.655772 — biochemistry — Posted on 2025-05-24
1013 Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection
Carbone, C. B.; Brown, M.; Balanca, C.; Antonelli, A. C.; Luoh, S.-M.; Banta, K. L.; Rouilly, V.; Pechuan-Jorge, X.; Ortiz-Munoz, G.; Cheung, J.; Marin, I.; Duong, E.; Anand, A.; Chan, C. K.; Rajagopalan, A.; Gibson, J. T.; Lorentzian, A.; Penna, E.; Jiang, J.; Rangell, L.; Liang, Y.; Decalf, J.; Barreira da Silva, R.; Zhu, Y.; Turley, S. J.; Strasser, G. A.; Sanjabi, S.; Geiger-Schuller, K.; Delamarre, L.; Mellman, I.; Moussion, C.
10.1101/2025.05.19.654765 — immunology — Posted on 2025-05-24
1014 Phosphorylation enables allosteric control of a viral condensate
Acker, J.; Wang, X.; Desiro, D.; Agarwal, T.; Colyer, A.; Haller, C.; Scrutton, R.; Sherry, L.; Saar, K. L.; Murray, R.; Fominykh, K.; Chong, S. H.; Schmit, J. D.; Calabrese, A. N.; Knowles, T. N.; Borodavka, A.
10.1101/2025.05.24.655949 — biophysics — Posted on 2025-05-24
1017 Human genetic variation shapes the antibody repertoire across B cell development
Rodriguez, O. L.; Qiu, X.; Shields, K.; Dunn, C.; Singh, A.; Kaileh, M.; Watson, C. T.; Sen, R.
10.1101/2025.05.19.654982 — genomics — Posted on 2025-05-24
1019 Mutations in specific MT5-MMP domains prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in cell models of Alzheimer's disease
Belio-Mairal, P.; Kamitsou, A.; Stephan, D.; Jullien, N.; Thiane, D.; Ramos, M.; Louis, L.; Benoist, F.; Serrano, B.; David, M.; Khrestchatisky, M.; Lecorche, P.; Nivet, E.; Rivera, S.
10.1101/2025.05.22.655451 — cell biology — Posted on 2025-05-24
1020 The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
Yigit, M.; Weber, R.; Ghoshdastider, U.; Das, A.; Nesanir, K.; Valdivia-Francia, F.; Hyams, K.; Taborsky, D.; Renz, P. F.; Ormiston, M.; Dure, C.; Yamahachi, H.; Jovanovic, M.; Sendoel, A.
10.1101/2025.05.22.655611 — molecular biology — Posted on 2025-05-24
1021 Adaptive Machine Learning Framework enables Unprecedented Yield and Purity of Adeno-Associated Viral Vectors for Gene Therapy
Idanwekhai, K.; Shastry, S.; Minzoni, A.; Hurst, M.; Barbieri, E.; Muratov, E.; Daniele, M.; Menegatti, S.; Tropsha, A.
10.1101/2025.05.23.655859 — molecular biology — Posted on 2025-05-24
1022 Identification and characterization of a non-peptidic cyclophilin ligand with antiviral activity against feline and porcine α-coronaviruses.
Delaplace, M.; Khan, M.; Huet, H.; Softic, L.; Ahnou, N.; Bigault, L.; Guichou, J.-F.; Ahmed-Belkacem, A.; Nevers, Q.; Le Poder, S.
10.1101/2025.05.24.655938 — microbiology — Posted on 2025-05-24
1023 A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency
Burgos, S. D.; Ward, A. M.; Ashokkumar, M.; Enders, K. P.; James, L. I.; Margolis, D. M.; Browne, E. P.
10.1101/2025.05.24.655900 — microbiology — Posted on 2025-05-24
1025 Selectivity filter mutation in NaV1.5 promotes ventricular tachycardia
Selimi, Z.; Tarasov, M.; Meng, X.; Dias, P.; Moise, B.; Veeraraghavan, R.; Radwanski, P.
10.1101/2025.05.19.654350 — physiology — Posted on 2025-05-24
1030 Cross-Species Prediction of Histone Modifications in Plants via Deep Learning
Lv, T.; Han, Q.; Li, Y.; Liang, C.; Ruan, Z.; Chao, H.; Chen, M.; Chen, D.
10.1101/2025.05.19.655006 — bioinformatics — Posted on 2025-05-24
1035 PURE: Policy-guided Unbiased REpresentations for structure-constrained molecular generation
Gupta, A.; Lenin, B.; Current, S.; Batra, R.; Ravindran, B.; Raman, K.; Parthasarathy, S.
10.1101/2025.05.21.655002 — biochemistry — Posted on 2025-05-24
1039 Optimizing Soybean Breeding: High-Throughput Phenotyping Technologies for Stink Bug Resistance and High Yields
de Oliveira, M.; Aono, A. H.; Braga, P.; Abreu Moreira, A.; Smaniotto Campion, F.; Krause, F. A.; Iost Filho, F. H.; de Bastos Pazini, J.; Takao Yamamoto, P.; Pinheiro, J. B.
10.1101/2025.05.19.654360 — genetics — Posted on 2025-05-24
1041 Characterisation of Ornithobacterium hominis colonisation dynamics and interaction with the nasopharyngeal microbiome in a South African birth cohort.
De Allende, C. C.; Salter, S. J.; Brigg, S. E.; Claassen-Weitz, S.; Mwaikono, K. S.; Workman, L.; Zar, H. J.; Nicol, M. P.; Parkhill, J.; Dube, F. S.
10.1101/2025.05.24.655922 — microbiology — Posted on 2025-05-24
1042 Life-Stage Transitions Drive Distinct Gut Viral Communities in Dairy Cattle
Cook, R.; Blanchard, A. M.; Marsh, C.; Ponsero, A. J.; Reynolds, J.; Adriaenssens, E. M.; Hudson, C.; Hobman, J.; Stekel, D. J.; Jones, M. A.; Millard, A. D.
10.1101/2025.05.24.655612 — microbiology — Posted on 2025-05-24
1044 Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
Medina-Serpas, M. A.; Brusko, M.; Golden, G. J.; Campbell-Thompson, M.; Rogers, T.; Posgai, A. L.; Luning-Prak, E. T.; Kaestner, K. H.; Betts, M. R.; McIntyre, L. M.; Atkinson, M. A.; Brusko, T. M.
10.1101/2025.05.19.654940 — immunology — Posted on 2025-05-24
1049 TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques
Tardajos-Ayllon, B.; Diagbouga, M. R.; Edsfeldt, A.; Kalucka, J.; Serbanovic-Canic, J.; Chambers, E.; Sun, J.; Gialeli, C.; Dunning, M.; Li, X.; Xu, S.; Francis, S. E.; Mammoto, A.; Simons, M.; Jorgensen, H. F.; Goncalves, I.; Evans, P. C.
10.1101/2025.05.19.654847 — pathology — Posted on 2025-05-24
1051 Employing neutron-encoded monoUbs to study E2/E3 ligase activity and selectivity for assembling Ub chains
van Tol, B. D. M.; van Doodewaerd, B. R.; Lageveen-Kammeijer, G. S. M.; Jansen, B. C.; Liwocha, J.; Mukhopadhyay, R.; Wuhrer, M.; van der Heden-van Noort, G. J.; Schulman, B. A.; Geurink, P. P.
10.1101/2025.05.22.655449 — biochemistry — Posted on 2025-05-24
1052 Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity
zhang, h.; li, x.; he, Q.; LIU, Y.; LIU, B.; LIU, Z.; CHEN, H.; ZHANG, S.; HAN, J.; LIU, Y.; YANG, J.; YIN, H.; GUO, Z.; WEI, Y.; YUAN, Z.; ZHU, H.
10.1101/2025.05.23.655875 — biochemistry — Posted on 2025-05-24
1053 A Tandem Repeat Atlas for the Genome of Inbred Mouse Strains: A Genetic Variation Resource
Ren, W.; Liu, W.; Fang, Z.; Dolzhenko, E.; Weisburd, B.; Cheng, Z.; Peltz, G.
10.1101/2025.05.23.655792 — genetics — Posted on 2025-05-24
1054 The MUC19 Gene: An Evolutionary History of Recurrent Introgression and Natural Selection
Villanea, F. A.; Peede, D.; Kaufman, E. J.; Anorve-Garibay, V.; Chevy, E. T.; Dillon, K. E. W.; Zeloni, R.; Marnetto, d.; Moorjani, P.; Jay, F.; Valdmanis, P. N.; Avila-Arcos, M. C.; Huerta-Sanchez, E.
10.1101/2023.09.25.559202 — evolutionary biology — Posted on 2025-05-24
1056 Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach
Agarwal, N.; Gogoi, H.; Eeba, E.; Augustin, L.; Khan, M. Y.; Kumar, Y.; Bhowmick, S. K.; Dey, B.
10.1101/2025.04.14.648691 — microbiology — Posted on 2025-05-24
1059 Bridging verbal coordination and neural dynamics
Schwab-Mohamed, I.; Mercier, M. R.; Trebuchon, A.; Morillon, B.; Lancia, L.; Schon, D.
10.1101/2024.04.23.590817 — neuroscience — Posted on 2025-05-24
1062 Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry
Boatman, A. K.; Kudzin, G. P.; Rock, K. D.; Guillette, M. P.; Robb, F.; Belcher, S. M.; Baker, E.
10.1101/2025.03.20.644452 — pharmacology and toxicology — Posted on 2025-05-24
1065 Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation
Sibih, Y. E.; Dada, A. O.; Cunningham, E. E.; Olshausen, N.; Kaur, J.; Jayabal, V.; Oten, S.; Herr, S.; Gonzales, C. N.; Daniel, A.; Krishna, S.; Ambati, V. S.; Aabedi, A. A.; Umbach, G.; Mirchia, K.; Lalwani, P.; Chang, E. F.; Raleigh, D. R.; Nagarajan, S.; Brang, D.; Hervey-Jumper, S. L.
10.1101/2025.05.23.655626 — cancer biology — Posted on 2025-05-24
1066 Development of Paclitaxel Resistance in Triple-Negative Breast Cancer Is Associated with Extensive DNA Methylation Changes That Are Partially Reversed by Decitabine
Trnkova, L.; Burikova, M.; Soltysova, A.; Ficek, A.; Plava, J.; Cumova, A.; Rojikova, L.; Jakic, K.; Sedlackova, E.; Tichy, B.; Bystry, V.; Busato, F.; Shen, Y.; Matuskova, M.; Kucerova, L.; Tost, J.; Miklikova, S.; Cihova, M.; Buocikova, V.; Smolkova, B.
10.1101/2025.05.22.655519 — cancer biology — Posted on 2025-05-24
1067 Circulating Biomarkers for Therapeutic Response to Immune Checkpoint Inhibitor Therapy in Patients with Advanced Lung Cancer
Jain, K.; Mehra, D.; Yadav, M.; Aggarwal, S.; Chugh, P.; tripathi, G.; Ganguly, S.; Rana, R.; Awasthi, A.; Ganguly, N. K.; Maras, J. S.
10.1101/2025.05.21.655239 — cancer biology — Posted on 2025-05-24
1069 Deficiencies in the Fanconi Anemia or the Homologous Recombination Pathway enhance the antitumor effects of the novel hypoxia-activated prodrug CP-506
Schuitmaker, L.; van der Wiel, A. M. A.; Lieuwes, N. G.; Biemans, R.; Mutsters, N. A. M.; Jung, J.; Claudino Bastos, V.; Prades Sagarra, E.; Kuang, S.; Langie, S. A. S.; Setton, J.; Theys, J.; Yaromina, A.; Dubois, L. J.; Lambin, P.
10.1101/2025.05.21.655302 — cancer biology — Posted on 2025-05-24
1070 Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer
Laforets, F.; Kotantaki, P.; Elorbany, S.; Hartlebury, J.; Joy, J. D.; Malacrida, B.; Bryan-Ravenscroft, R. C.; Berlato, C.; Di Federico, E.; Marshall, J. F.; Manchanda, R.; Jarolimek, W.; Perryman, L.; Maniati, E.; Balkwill, F. R.
10.1101/2025.05.19.654864 — cancer biology — Posted on 2025-05-24
1071 SMARCA4 is essential for early-stage tumor development but its loss promotes late-stage cancer progression in small-cell lung cancer
PARK, K.-S.; Kirk, N. A.; Ly, K.-L.; Ban, Y. H.; Dzhivhuho, G. A.; Ng, J.; Sutherland, K.; Thomas, A.; Kareta, M. S.; Karnezis, A. N.; Park, J.-I.; Jang, J.; Ko, K.-P.
10.1101/2025.05.21.655382 — cancer biology — Posted on 2025-05-24
1072 In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients
Jermakowicz, A.; Ruiz, L.; Chu, J.; Jange, N.; Suter, R. K.; Kadan-Lottick, N.; Hanson, D.; Ayad, N. G.
10.1101/2025.05.23.655845 — cancer biology — Posted on 2025-05-24
1073 PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes
Risner, A.; Nair-Menon, J.; Cheedipudi, A.; Delaney, J. R.; Gangaraju, V.; Kourtidis, A.
10.1101/2025.05.20.655197 — cancer biology — Posted on 2025-05-24
1074 Single-Cell Analysis of Meningiomas Reveals Mutation-Associated Tumor and Immune Cell Gene Expression Programs
Maldonado, J. A.; Mashimo, B. L.; Wang, A. Z.; Desai, R.; Khan, S. M.; Sherpa, N. D.; Anzaldua-Campos, M. I.; Zipfel, G. J.; Kim, A. H.; Dowling, J. L.; Leuthardt, E. C.; Osbun, J. W.; Vellimana, A. K.; Chicoine, M. R.; Dunn, G. P.; Petti, A. A.
10.1101/2025.05.21.655421 — cancer biology — Posted on 2025-05-24
1075 Determining preclinical safety of Aclarubicin in pediatric malignancies
Tu, D. S.; Olson, A. K.; Waggie, K. S.; Garcia, N. M.; Hoglund, V. J.; Walter, S.; Rosinski, J. R.; Sadeeshkumar, H.; Patel, R.; Sayar, E.; Haffner, M.; Maves, L.; Neefjes, J.; Sarthy, J. F.; Lawlor, E. R.; Ganapathi, S. S.
10.1101/2025.05.20.654130 — cancer biology — Posted on 2025-05-24
1076 Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy
Goliwas, K.; Hough, K. P.; Sivan, S.; Single, S. L.; Deshmukh, S. S.; Berry, J. L.; Khalil, M.; Wei, B.; Boumber, Y.; Athar, M.; Desai, A.; Ponnazhagan, S.; Donahue, J. M.; Deshane, J. S.
10.1101/2025.05.19.654890 — cancer biology — Posted on 2025-05-24
1077 Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2
Althoff, M. J.; Minhajuddin, M.; Stevens, B.; Gillen, A. E.; Gipson, S.; Patel, S. B.; Shelton, I. T.; Miller, R.; Vujovic, A.; Krug, A.; Young, T.; Showers, W. M.; Dzieciatkowska, M.; Stephenson, D.; Tyagi, A.; Ellegast, J. M.; Wright, T.; Stegmaier, K.; Opferman, J. T.; D'Alessandro, A.; Smith, C. A.; Jordan, C. T.
10.1101/2025.05.22.655396 — cancer biology — Posted on 2025-05-24
1080 The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma
Durand, S.; Boivin, F.; Pommier, R.; Barbollat-Boutrand, L.; Grimont, M.; Pham, F.; Dufeu, M.; Cumunel, E.; Schneider, R.; Ferrari, A.; Eberhardt, A.; Dalle, S.; CARAMEL, J.
10.1101/2025.05.20.654822 — cancer biology — Posted on 2025-05-24
1082 Integrative Multi-Omics Analysis Identifies Nuclear Factor I as a Key Driver of Dysregulated Purine Metabolism in DIPG
Mersich, I.; Congrove, S.; Horchar, M.; Caceres, R.; Muraleedharan, R.; Desai, J.; Desai, P.; Sallans, L.; Reisz, J. R.; Grier, A.; Hass, M.; Donmez, O.; Yin, C.; Weirauch, M. T.; Kottyan, L. T.; Stevenson, C.; Sun, C.; deBlank, P.; Pillay-Smiley, N.; Hummel, T.; Elumalai, N.; Tavassoli, A.; Firestein, R.; Phoenix, T.; D'Alessandro, A.; Dasgupta, B.
10.1101/2025.05.21.655327 — cancer biology — Posted on 2025-05-24
1083 PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
Rao, X.; Allison, D. B.; Flight, R. M.; Lin, P.; He, D.; Li, Z.; Zhang, Y.; Wang, R.; Li, C.; Wang, J.; Wang, X.; Peng, J.; Fong, K.-W.; Shao, Q.; Wang, C.; Ali, E. S.; Moseley, H. N.; Liu, X.
10.1101/2025.05.21.655274 — cancer biology — Posted on 2025-05-24
1085 Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma
Adhikary, P.; Chakrabarti, J.; Wang, J.; Ezuma-Igwe, U.; Sun, X.; Bastian, W. C.; Braissand, N.; Corbett, M. P.; Douglass, E.; Kim, S.; Kanakamedala, R.; Branch, A. G.; Mallick, S.; Resmi, M. P.; Stevens, P.; Padilla-Rodriguez, M.; Sanchez, M.; Beatty, G. L.; Griffin, J.; Nikolinankos, P. G.; Chen, K.; Riall, T.; Ahmad, S. A.; Shroff, R.; Hollande, F.; Sohal, D.; Zavros, Y.
10.1101/2025.05.22.655586 — cancer biology — Posted on 2025-05-24
1086 Contrastive Representation Learning for Single Cell Phenotyping in Whole Slide Imaging of Enrichment-free Liquid Biopsy
Naghdloo, A.; Tessone, D.; Mandya Nagaraju, R.; Zhang, B.; Kang, J.; Li, S.; Oberai, A.; Hicks, J. B.; Kuhn, P.
10.1101/2025.05.21.655334 — cancer biology — Posted on 2025-05-24
1087 Repurposing Romidepsin for Osteosarcoma: Screening FDA-Approved Oncology Drugs with Three-Dimensional Osteosarcoma Spheroids
Seiden, E. E.; Richardson, S.; Everitt, L. A.; Knafler, G. J.; Kinsella, G. P.; Walker, A. L.; Whiteside, V. A.; Buschbach, J. D.; Gandhi, D. A.; Saadatzadeh, M. R.; Wurtz, L. D.; Getty, P. J.; Padgett, S. L.; Gamblin, R. M.; Childress, M. O.; Fulkerson, C. M.; Pollok, K. E.; Collier, C. D.; Greenfield, E. M.
10.1101/2025.05.22.654354 — cancer biology — Posted on 2025-05-24
1088 Feeding induces c-Fos in hepatocytes contributing to hepatocellular carcinoma in obesity
Li, A.; Gilglioni, E. H.; St-Pierre-Wijckmans, W.; Hosseinzadeh, L.; Veyrat-Durebex, C.; Singh, S. P.; Coppari, R.; Bakiri, L.; Gurzov, E. N.
10.1101/2025.05.20.654880 — cancer biology — Posted on 2025-05-24
1089 An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with Glioblastoma cells stemness features and migration.
D'ARRIGO, P.; DUBOIS, M.; SANCHEZ GIL, J.; LASSENCE, C.; BROUWERS, B.; LOMBARD, A.; ROGISTER, B.; NEIRINCKX, V.; LEBRUN, M.; SADZOT-DELVAUX, C.
10.1101/2025.05.21.655102 — cancer biology — Posted on 2025-05-24
1090 A New Class of Precision Therapeutics that Inhibit Prostate Cancer Mediated Bone Destruction
Qiao, F.; Gordon, R.; Pattanayak, A.; Li, W.; Knibbe-Hollinger, J.; O'Neill, K.; Chen, W.; Mukthapuram, P. R.; Natarajan, A.; Bergan, R.
10.1101/2025.05.20.654990 — cancer biology — Posted on 2025-05-24
1091 Primary CD34+ cells of patients with VEXAS syndrome are highly sensitive to targeted treatment with TAK-243 and pevonedistat
Nowak, D.; Demmerle, M.; Klär, A.; Streuer, A.; Riabov, V.; Altrock, E.; Rapp, F.; Belzer, A.-C.; Klink, T.; Hahn, M.; Hofmann, F.; Nowak, V.; Weimer, N.; Obländer, J.; Palme, I.; Göl, M.; Darwich, A.; Steiner, L.; Abba, M.; Metzgeroth, G.; Hofmann, W.-K.; Schmitt, N.
10.1101/2025.05.22.653244 — cancer biology — Posted on 2025-05-24
1092 A First-in-Class Therapy Targeting Transcription-Replication Conflicts Drives Synthetic Lethality in Homologous Recombination Deficient Cancers
Lim, Y. C.; Lai, S. K.; Yang, R. H.; Chua, Y. K.; Patouret, R.; Manoj, V.; Soh, C.; Lebeau, B.; Cham, N.; Meng, W.; Tey, S. K.; Yeap, S. L.; Zhang, S.; Yong, J.; Ali, Z.; Mutwil, M.; Singh, P.; Fullwood, M.; Zhong, L.; Dong, X.; Chiba, S.; Koh, C. G.; Li, H. Y.
10.1101/2025.05.21.655390 — cancer biology — Posted on 2025-05-24
1093 IL-17A potentiates malignant T-cell viability via electron transport chain complex I in cutaneous T-cell lymphoma
Attrish, D.; Dhamija, B.; Mukherjee, D.; Sawant, V.; Marathe, S.; Saul, D.; Basu, M.; Banik, A.; Sharma, N.; Shet, T.; Jain, H.; Kosinsky, R. L.; Sharma, P.; Purwar, R.
10.1101/2025.05.21.655309 — cancer biology — Posted on 2025-05-24
1095 Ketogenic diet prevents obesity-associated pancreatic cancer independent of weight loss and induces pancreatic metabolic reprogramming
Velez-Bonet, E.; Gumpper-Fedus, K.; Chasser, K.; Hurst, Z.; Hsueh, H.-Y.; Pita-Grisanti, V.; Liette, A.; Vulic, G.; Choueiry, F.; Zhang, H.; Zhu, J.; Knoblaugh, S. E.; Culp, S.; Volek, J. S.; Cruz-Monserrate, Z.
10.1101/2025.05.20.655200 — cancer biology — Posted on 2025-05-24
1096 Proteomic analysis of exosomes from lymphatic affluents reveals their implications in developing premetastatic niche in melanoma.
Suman, S.; Geng, L.; Nevala, W. K.; Zhao, X.; Sung, J.; Jakub, J. W.; Kandasamy, R. K.; McLaughlin, S. A.; Pandey, A.; Markovic, S. N.
10.1101/2025.05.21.655399 — cancer biology — Posted on 2025-05-24
1097 predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs
Hansen, J.; Iyengar, R.; Martinez, P.; Yadaw, A. S.; Xiong, Y.; Racz, R.; Pacanowski, M. A.; Hopkins, L. L.; King, N. M. P.; Abernethy, D.; Sobie, E.
10.1101/2025.05.23.655401 — cancer biology — Posted on 2025-05-24
1099 Overcoming treatment resistance mediated by the bone marrow vascular niche in acute myeloid leukemia
Froid, M.; Branciamore, S.; Chen, Z.; Frankhouser, D.; Fu, Y.-H.; Ambriz, J. R.; Nguyen, L. X. T.; Irizarry, J.; Kuo, Y.-H.; O'Meally, D.; Zhang, B.; Marcucci, G.; Rockne, R.; Basanta, D.
10.1101/2025.05.22.655592 — cancer biology — Posted on 2025-05-24
1100 Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer
Li, H.; Younger, N. S.; Malik, B.; Shin, H. J.; Zhang, C.; Niknafs, Y.; Zhao, S.; Wilder-Romans, K.; Pitchiaya, S.; Han, S.; Barnard, T. J.; Lloyd, P.; Zhang, M.; Chesner, L. N.; Calvert, M.; Egusa, E. A.; Zhu, J.; Chou, J.; Das, R.; Kothari, V.; Shenoy, T.; Diolaiti, M. E.; Malik, R.; Prensner, J. R.; Burlingame, A. L.; Ashworth, A.; Chinnaiyan, A. M.; Feng, F.; Li, H.
10.1101/2025.05.21.655369 — cancer biology — Posted on 2025-05-24
1101 Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma
Zhang, Y.; Debaize, L.; Langenbucher, A.; Weekes, J.; Vogiatzi, I.; Miettinen, T. P.; Zhang, M.; Sumpena, E.; Liu, H.; Duquette, S.; Hackett, L.; Zhang, J.; Baghiyan, S.; Redd, R. A.; Aryee, M.; Davids, M. S.; Kim, A. I.; Ryan, C. E.; Weinstock, D. M.; Manalis, S.; Murakami, M. A.
10.1101/2025.05.20.655210 — cancer biology — Posted on 2025-05-24
1102 Cheminformatic identification of small molecules targeting acute myeloid leukemia
Daneman, M. R.; Meika, B.; Tjahjono, E.; Revtovich, A. V.; Stolbov, L. A.; Gilbertson, S. R.; Poroikov, V. V.; Kirienko, N. V.
10.1101/2025.05.20.655224 — cancer biology — Posted on 2025-05-24
1103 DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres
Ragupathi, A.; Abid, H. Z.; Chen, Y.; Zhao, R.; Kosiyatrakul, S. T.; Yetil, D. I.; Neiswander, J.; Feltman, R.; Thomas, S.; Yusupov, B.; Singh, M.; Zheng, L.; Shen, B.; Zhang, H.; Chu, H.-P. C.; Schildkraut, C. L.; Xiao, M.; Zhang, D.
10.1101/2025.05.22.655602 — cancer biology — Posted on 2025-05-24
1104 Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease
Zarkoob, H.; Kam, C.; Koetsier, J.; Jaiganesh, A.; McCarthy, E.; Kelsell, D.; Sheikh, F.; Godsel, L. M.; Green, K. J.
10.1101/2025.05.21.655405 — cell biology — Posted on 2025-05-24
1105 Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices
Tsolias, A.; Mojica, C. A.; Yamani, R.; Khanna, S. D.; Abdullatif, S. A.; Snyder, B. J.; Chang, W.; Guillamon-Vivancos, T.; Goodliffe, J.; Capriglione, A. L.; Palanca, I. L. T.; Martinez, J.; Campbell, J. D.; Luebke, J. I.; Zeldich, E.; Medalla, M.
10.1101/2025.05.23.655820 — neuroscience — Posted on 2025-05-24
1108 Lineage recording in monoclonal gastruloids reveals heritable modes of early development
Regalado, S. G.; Qiu, C.; Kottapalli, S.; Martin, B. K.; Chen, W.; Liao, H.; Kim, H.; Li, X.; Lalanne, J.-B.; Hamazaki, N.; Domcke, S.; Choi, J.; Shendure, J.
10.1101/2025.05.23.655664 — developmental biology — Posted on 2025-05-24
1110 Single kinetochores execute an ordered series of molecular events as the Spindle Assembly Checkpoint is silenced
Conway, C. C.; Germanova, T.; Toral-Perez, S.; Coates, C.; Pines, J.; Burroughs, N. J.; McAinsh, A. D.
10.1101/2025.05.23.655733 — cell biology — Posted on 2025-05-23
1111 Age-associated Tissue Organisation Shifts Retinal Pigment Epithelium Actomyosin Plasticity in Phagocytosis
Piskova, T.; Kozyrina, A. N.; Astrauskaite, G.; Elsafi Mabrouk, M. H.; Schepl, S.; Yam, S. L. S.; Ravithas, R.; Wagner, W.; Vassalli, M.; Di Russo, J.
10.1101/2025.05.22.655517 — cell biology — Posted on 2025-05-23
1112 New glucose-abstaining Chlorella algae doubles mammalian cell culture longevity, boosts performance and drops serum needs enabling scaled applications.
Oey, M.; Marx, U.; Schirra, H. J.; Curson, J. E. B.; Amado, M.; Ross, I. L.; Sweet, M. J.; Blaskovich, M.; Parton, R. G.; Hankamer, B.; Lo, H.
10.1101/2025.05.21.655407 — cell biology — Posted on 2025-05-24
1114 A Multimodal Spatial and Epigenomic Atlas of Human Adult Lung Topography
Duong, T. E.; Diep, D.; Conklin, K. Y.; Bui, I.; Purkerson, J. M.; Boone, E.; Olness, J.; Patel, S.; Peng, B.; Kern, J. C.; Zhao, Z.; Misra, R. S.; Huyck, H. L.; Verheyden, J. M.; Borok, Z.; Zhang, Y.; Scheuermann, R. H.; Zhu, Q.; Deutsch, G.; Hagood, J. S.; Sun, X.; Zhang, K.; Pryhuber, G.
10.1101/2025.05.23.655666 — cell biology — Posted on 2025-05-24
1115 An innovative in vitro model for studying the biology of cardiac fibroblasts originating from the epicardium
Muller-Sanchez, C.; Muniz-Banciella, M. G.; Reina, M.; Soriano, F. X.; Martinez-Estrada, O. M.
10.1101/2025.05.23.655755 — cell biology — Posted on 2025-05-24
1116 Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation
Srivastava, S.; Samaniego-Castruita, D.; Khurana, S.; Shukla, V.; Ben-Sahra, I.; Foltz, D. R.
10.1101/2025.05.21.655426 — cell biology — Posted on 2025-05-24
1118 AMPA receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving
Sanchez, L. L. H.; Tadros, M. G.; Doan, H. H. T.; Chaudhari, S. R.; Vo, S. V.; Li, T. L.; James, P. B.; Na, A. Y.; Cano, F. J.; Szumlinski, K. K.
10.1101/2025.05.21.655393 — neuroscience — Posted on 2025-05-23
1120 Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature and cytoarchitecture.
Priovoulos, N.; Bazin, P.-L.; Brouwer, E. J. P.; Mejias, J. F.; de Buck, M. H. S.; Alkemade, A.; van der Zwaag, W.; Caan, M. W. A.
10.1101/2025.05.23.655715 — neuroscience — Posted on 2025-05-23
1123 Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis
Naikawadi, R. P.; Bazarov, A.; Wax, M.; Boostanpour, K.; Kukreja, J.; Traglia, M.; Agrawal, A.; Thomas, R.; Bhattacharya, M.; Wolters, P.
10.1101/2025.05.22.655638 — cell biology — Posted on 2025-05-23
1125 Cryo-Correlative Light and X-ray microscopies: Expanding the Intracellular Chemical Map
Karpov, D.; Cuau, L.; Shishkov, R.; Gramaccioni, C.; Dallerba, E.; Schwehr, B.; Hackett, M.; Plush, S.; Massi, M.; Lerouge, F.; Cloetens, P.; Bohic, S.
10.1101/2025.05.23.655741 — cell biology — Posted on 2025-05-23
1126 Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide.
Akgün, S.; Lenz, T.; Zink, A.; Krings, K. S.; Wesselborg, S.; Mendiburo, M. J.; Prigione, A.; Stühler, K.; Stork, B.
10.1101/2025.05.22.655294 — cell biology — Posted on 2025-05-23
1127 Mutations in specific MT5-MMP domains prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in cell models of Alzheimer's disease
Rivera, S.; Belio-Mairal, P.; Kamitsou, A.; Stephan, D.; Jullien, N.; Thiane, D.; Ramos, M.; Louis, L.; Benoist, F.; Serrano, B.; David, M.; KHRESTCHATISKY, M.; Lecorche, P.; Nivet, E.
10.1101/2025.05.22.655451 — cell biology — Posted on 2025-05-23
1129 A Dual Role for DGAT-mediated Lipid Droplet Biogenesis in Ferroptosis Regulation
Kump, A.; Perne, L.; Koren, S.; Jarc Jovicic, E.; Fegus, N.; Pinto Kozmus, C.; Wölk, M.; Brejchova, K.; Fedorova, M.; Kuda, O.; Petan, T.
10.1101/2025.05.21.655263 — cell biology — Posted on 2025-05-23
1130 Senotherapeutic potential against xeroderma pigmentosum
Wang, X.; Nishida, M.; Yoshioka, A.; Chung, C. Y.-L.; Hashimoto, S.; Tanizawa, H.; Ohta, S.; Noma, K.-i.; Fukumoto, T.
10.1101/2025.05.22.655641 — cell biology — Posted on 2025-05-23
1131 RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response
Ballard-Kordeliski, A.; Ziegmann, N.; Schug, W.; Ginsberg, M. H.; Schaefer, A.; Lee, R. H.; Bergmeier, W.
10.1101/2025.05.22.655614 — cell biology — Posted on 2025-05-23
1133 The interplay between Caenorhabditis elegans larval development and Orsay virus infection
Melero, I.; Castiglioni, V. G.; Olmo-Uceda, M. J.; Olmedo, M.; Gonzalez, R.; Elena, S. F.
10.1101/2025.05.23.655711 — microbiology — Posted on 2025-05-23
1137 Scaling law links plant growth variation to grain yield in wheat stands
Golan, G.; Vasseur, F.; Huang, Y.; Tan, K.; Sadras, V.; violle, c.; Schnurbusch, T.
10.1101/2025.05.19.654792 — plant biology — Posted on 2025-05-23
1142 Pyrethroid resistance intensity in Anopheles gambiae s.l. mosquito populations from Rwanda
Lambert, N.; Torbert Yvan, M.; Pascal, M.; Gerald, H.; Alphonse, M.; Aimable, M.; Dunia, M.; Emmanuel, H.
10.1101/2025.05.21.655281 — evolutionary biology — Posted on 2025-05-23
1143 Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening
Casas, A.; Imlay, L. S.; Thathy, V.; Fairhurst, K. J.; Lehane, A. M.; Lawong, A. K.; Deni, I.; Striepen, J.; Lee, S.; Kumar, A.; Xing, C.; Niederstrasser, H.; Posner, B. A.; Laleu, B.; Charman, S. A.; Fidock, D. A.; Ready, J. M.; Phillips, M. A.
10.1101/2025.05.20.655166 — microbiology — Posted on 2025-05-23
1145 Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies
Wagner-Carena, J. A.; Kate, S.; Riordan, T.; Abbasi-Asl, R.; Aman, J.; Amster, A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Buice, M. A.; Bumbarger, D. J.; Collman, F.; da Costa, N. M.; Denman, D. J.; de Vries, S. E.; Joyce, E.; Kapner, D.; King, C. W.; Larkin, J. D.; Lecoq, J.; Mahalingam, G.; Millman, D.; Molter, J.; Morrison, C.; Reid, R. C.; Schneider-Mizell, C. M.; Daniel, S.; Suckow, S.; Takasaki, K. T.; Torres, R.; Vumbaco, D.; Waters, J.; Wyrick, D. G.; Yin, W.; Zhuang, J.; Takeno, M.; Mihalas, S.; Berteau, S.
10.1101/2025.04.24.649900 — neuroscience — Posted on 2025-05-23
1147 Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta
Khajuria, P.; Kour, D.; Sharma, K.; Singh, L.; Banoo, R.; Manhas, D.; P, R.; Nandi, U.; Bharate, S.; Ahmed, Z.; Kumar, A.
10.1101/2025.05.19.654834 — pharmacology and toxicology — Posted on 2025-05-23
1155 Decoding protein-peptide interactions using a large, target-agnostic yeast surface display library
Hurley, J.; Shlosman, I.; Lakshminarayan, M.; Zhao, Z.; Yue, H.; Nowak, R.; Fischer, E. S.; Kruse, A.
10.1101/2025.05.19.654863 — bioengineering — Posted on 2025-05-23
1158 De Novo Hydration of Cryo-EM Reconstructions through Molecular Dynamics Simulations of the Excess Chemical Potential
Sun, Q.; Aiyer, S.; Biswas, A.; Haldane, A.; Chatterjee, S.; Matubayasi, N.; Lyumkis, D.; Levy, R. M.
10.1101/2025.05.23.655847 — biochemistry — Posted on 2025-05-23
1159 Regulation of the essential peptidoglycan hydrolytic complex FtsEX-PcsB during Streptococcus pneumoniae cell division
Briggs, N. S.; Bruce, K. E.; Camaione, S.; Naskar, S.; Lloyd, A. J.; Winkler, M. E.; Roper, D. I.
10.1101/2025.05.23.655736 — biochemistry — Posted on 2025-05-23
1162 Directing conservation action for the Critically Endangered Philippine Eagle to mitigate mining impacts and maximize indigenous land management
Sutton, L. J.; Ibanez, J. C.; Salvador, D. I.; Tirona, A. V. M. C.; Opiso, G. S.; Senarillos, T. L. P.; Suetos, K. J.; Taraya, R. L.; McClure, C. J. W.
10.1101/2025.05.19.654818 — ecology — Posted on 2025-05-23
1164 Anti-resonance in developmental signaling regulates cell fate decisions
Rosen, S. J.; Witteveen, O.; Baxter, N.; Lach, R. S.; Hopkins, E.; Bauer, M.; Wilson, M. Z.
10.1101/2025.02.04.636331 — cell biology — Posted on 2025-05-23
1165 Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Zhang, C.; Liang, N.; Li, W.; Xu, S.; Li, P.; Ni, W.; Li, N.; Han, S.; Ou, N.; Bai, H.; Zhang, Y.; Bai, F.; Sun, Y.; Qian, D.; Bu, X.; Zhi, E.; Tian, R.; Huang, Y.; Zhao, J.; Zhao, F.; chen, H.; Li, Z.; Yao, C.
10.1101/2025.05.21.654986 — molecular biology — Posted on 2025-05-23
1168 Commensal to pathogen switch in Streptococcus pneumoniae is governed by a thermosensing master regulator
Apte, S.; Pereira, G.; Ghosh, S.; Mandal, S. K.; Badgujar, L.; Gosavi, K.; Pohler, E.; Blake, A.; PI, P.; Neill, D. R.; Banerjee, A.
10.1101/2025.05.23.655729 — microbiology — Posted on 2025-05-23
1170 Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during Mycobacterium tuberculosis infection
Hazra, R.; Ozturk, M.; Peton, N.; Ganief, T.; Poswayo, S. K.; Rousseau, R. P.; Naidoo, S.; Jones, S.-S.; Savulescu, A. F.; Moseki, R.; Abhimanyu, A.; Plessis, N. D.; Blackburn, J.; Mhlanga, M. M.; Kahn, C. R.; Brombacher, F.; Wilkinson, R. J.; Parihar, S. P.
10.1101/2025.05.19.653976 — immunology — Posted on 2025-05-23
1171 Potent Neutralization by Antibodies Targeting the Mpox A28 Protein
Yefet, R.; Battini, L.; Hubert, M.; Rakayev, K.; GUIVEL-BENHASSINE, F.; Rattner, N.; Porrot, F.; Abramovitz, L.; Ostashinsky, G.; Ben-Shalom, N.; Postal, J.; Polonsky, K.; Ralph-Altman, M.; Sweed, S.; Korner, T.; Friedel, N.; Hagin, D.; Sprecher, E.; Fishelson, Z.; Kobiler, O.; Adler-Abramovich, L.; Schwartz, O.; Guardado-Calvo, P.; Freund, N.
10.1101/2025.05.22.655505 — immunology — Posted on 2025-05-23
1172 The maternal inflammatory proteome during pregnancy and its role in predicting the risk of spontaneous preterm birth
Laleye, F.; Jackson, R.; Mi, J. D.; Shennan, A. H.; Hezelgrave - Elliott, N.; Vigilante, A.; Camunas-Soler, J.; Rasmussen, M.; Tribe, R. M.
10.1101/2025.05.19.654577 — systems biology — Posted on 2025-05-23
1173 Using domain insertion to create sulfite reductases that present chemical-dependent activities
Windham, E.; Myerscough, D.; Schwartz, S.; Carpenter, M.; Ajo-Franklin, C.; Silberg, J.
10.1101/2025.05.23.655854 — synthetic biology — Posted on 2025-05-23
1174 In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis
Vu, K. P.; Gunti, S.; Viswanathan, R.; Nandal, A.; Larkin, R.; Cho, S.; Zou, J.; Ramolia, S.; Hoke, A. T. K.; Barbosa, S. M.; Gallia, G. L.; Rooper, L. M.; Floudas, C. S.; Cheng, H.; Miller, C. N.; Guest, M. R.; Notaro, M.; Raziuddin, A.; Sun, Z.; Wu, X.; Faraji, F.; Lechner, M.; Comoglio, F.; Edmondson, E. F.; Chari, R.; London, N. R.
10.1101/2025.05.19.654661 — cancer biology — Posted on 2025-05-23
1175 Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein
Johnson, D. H.; Kou, O. H.; White, J. M.; Ramirez, S. Y.; Margaritakis, A.; Chung, P. J.; Jaeger, V. W.; Zeno, W. F.
10.1101/2024.11.14.623669 — biophysics — Posted on 2025-05-23
1176 D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response
Jiang, J.; Chen, S.; Tsou, T.; McGinnis, C. S.; Khazaei, T.; Zhu, Q.; Park, J. H.; Strazhnik, I.-M.; Vielmetter, J.; Gong, Y.; Hanna, J.; Chow, E. D.; Sivak, D. A.; Gartner, Z. J.; Thomson, M.
10.1101/2023.04.19.537364 — bioinformatics — Posted on 2025-05-23
1178 RBPSignal: A deep learning approach for predicting RNA-Protein binding signals
Ding, X. S.; Shu, Z. A.; Wang, S.; Shi, L.; Zhou, Y.; Zhang, B.; Shen, H.-B.; Liu, X.; Pan, X.
10.1101/2025.05.19.654811 — bioinformatics — Posted on 2025-05-23
1179 Multiscale analysis and optimal glioma therapeutic candidate discovery using the CANDO platform
XU, S.; Mangione, W.; Norden, M. V.; Elefteriou, K.; Hu, Y.; Falls, Z.; Samudrala, R.
10.1101/2025.05.19.654757 — bioinformatics — Posted on 2025-05-23
1183 Aeromonas: Genomic Insights into an Environmental Pathogen and Reservoir of Antimicrobial Resistance
Singh, N.; Golicha, R. O.; Thakur, C.; Beale, M. A.; Dorman, M. J.; Cazares, A.; Taylor-Brown, A.; Johura, F.-T.; Rashid, M. u.; Monira, S.; Zohura, F.; Parveen, T.; Bhuiyan, S. I.; Sultana, M.; Mohan, B.; Domman, D.; George, C. M.; Kariuki, S.; Alam, M.; Taneja, N.; Thomson, N. R.
10.1101/2025.05.22.655522 — genomics — Posted on 2025-05-23
1185 A cell and transcriptome atlas of the human arterial vasculature reveals roles of developmental master regulators in health and disease
Zhao, Q.; Pedroza, A.; Sharma, D.; Gu, W.; Dalal, A.; Weldy, C.; Jackson, W.; Li, D. Y.; Ryan, Y.; Nguyen, T.; Shad, R.; Palmisano, B. T.; Monteiro, J. P.; Worssam, M.; Berezwitz, A.; Iyer, M.; Shi, H.; Kundu, R.; Limbu, L.; Kim, J. B.; Kundaje, A.; Fischbein, M.; Wirka, R.; Quertermous, T.; Cheng, P.
10.1101/2024.09.10.612293 — cell biology — Posted on 2025-05-23
1187 Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice
Sakaue, H.; Izumi-Mishima, Y.; Tsutsumi, R.; Shiuchi, T.; Fujimoto, S.; Taniguchi, M.; Sugiuchi, M.; Tsutsumi, M.; Okamatsu-Ogura, Y.; Yoneshiro, T.; Kuroda, M.; Nomura, K.
10.1101/2024.05.26.595945 — molecular biology — Posted on 2025-05-23
1188 Cardiac neurotrophic signaling impairment, amyloid β, and the Alzheimer s disease heart
Elia, A.; Parodi-Rullan, R. M.; Vazquez-Torres, R.; Carey, A.; Javadov, S.; Fossati, S.
10.1101/2023.07.11.548558 — molecular biology — Posted on 2025-05-23
1189 Bacteria detect neutrophils via a system that responds to hypochlorous acid and flow
Foik, I. P.; Shu, R.; Abbondante, S.; Kasallis, S. J.; Urban, L. A.; Huang, A. P.; Duong, L.; Marshall, M. E.; Pearlman, E.; Downing, T. L.; Siryaporn, A.
10.1101/2022.02.01.478687 — microbiology — Posted on 2025-05-23
1190 Highly Pathogenic Avian Influenza A(H5N1) Caused Mass Death among Black-legged Kittiwakes (Rissa tridactyla) in Norway, 2023
Romo, G.; Piercey Akesson, C.; Reiertsen, T. K.; Fosse, J. H.; Arnason Boe, C.; Austbo, L.; Akerstedt, J.; Saghafian, M.; Helberg, M.; Hungnes, O.; Gjerset, B.; Granstad, S.; Hogseth, G.; Lotvedt, S.; Dosen, A.; Tonnessen, R.
10.1101/2025.05.23.655725 — microbiology — Posted on 2025-05-23
1191 Melatonin Enhances Sleep via MT1-Driven Activation of Slo1 in Suprachiasmatic Nucleus Neurons
Wang, Z.-W.; Vedantham, K.; Ahmad, A.; Niu, L.-G.; Shui, Y.; Lemtiri-Chlieh, F.; Kaback, D.; Ma, X.-M.; Yee, S.-P.
10.1101/2025.03.12.642893 — neuroscience — Posted on 2025-05-23
1195 Orexin population activity precisely reflects net body movement across behavioral and metabolic states
Tesmer, A. L.; Viskaitis, P.; Donegan, D.; Bracey, E.; Grujic, N.; Patriarchi, T.; Peleg-Raibstein, D.; Burdakov, D.
10.1101/2024.08.13.607750 — neuroscience — Posted on 2025-05-23
1199 A Chromosome-scale Reference Genome of Meloidogyne hapla reveals localized recombination hotspots enriched with Effector Proteins
Shakya, P.; Maulana, M. I.; Danchin, E.; Voogt, M. l.; van de Ruitenbeek, S. J. S.; Gimeno, J.; Taranto, A. P.; Blundell, A. C.; Despot-Slade, E.; Mestrovic, N.; Mota, A. Z.; Dai, D.; Williamson, V. M.; Sterken, M. G.; Siddique, S.
10.1101/2025.05.21.654606 — plant biology — Posted on 2025-05-23
1200 RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription
Jangde, N.; Lee, M. H.; Ruiz, L.; Egan, I.; Jermakowicz, A.; Wynn, D.; Goka, E.; Lippman, M.; Robbins, D. J.; Ayad, N. G.
10.1101/2025.05.22.655563 — pharmacology and toxicology — Posted on 2025-05-23
1201 Testing for a wildlife reservoir of divergent SARS-CoV-2 in white-tailed deer
Crawshaw, L.; Kotwa, J. D.; Jeeves, S. P.; Loomer, C.; Dibernardo, A.; Stewart, A.; Newar, S. L.; Chien, E.; Yim, W.; Kruczkiewicz, P.; Vernygora, O.; Lung, O.; Schulte-Hostedde, A. I.; Maguire, F.; Pickering, B.; Jardine, C. M.; Coatsworth, H.; Mubareka, S.; Bowman, J.
10.1101/2025.05.22.655348 — pathology — Posted on 2025-05-23
1203 Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds
Alonso Matilla, R.; Pedro, D. I.; Pepe, A.; Serrano-Velez, J.; Dunne, M.; Nguyen, D. T.; Sawyer, W. G.; Provenzano, P. P.; Odde, D. J.
10.1101/2023.10.29.564655 — biophysics — Posted on 2025-05-23
1206 A Gm6AG-binding protein from Vibrio cholerae.
cao, y.; xu, j.; lu, x.; huang, f.; chen, w.; wang, x.; zhu, b.
10.1101/2025.05.22.655678 — biochemistry — Posted on 2025-05-23
1207 Draft genome and transcriptomic sequence data of three invasive insect species
Lombaert, E.; Klopp, C.; Blin, A.; Annonay, G.; Iampietro, C.; Lluch, J.; Sallaberry, M.; Valiere, S.; Poloni, R.; Joron, M.; Deleury, E.
10.1101/2024.12.02.626401 — genomics — Posted on 2025-05-23
1208 Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit
Sanders, E. N.; Sun, H.-T.; Tabatabaee, S.; Lang, C. F.; van Dijk, S. G.; Su, Y.-H.; Labott, A.; Idris, J.; He, L.; Marchetti, M.; Xie, S.; O'Brien, L. E.
10.1101/2024.12.29.630675 — developmental biology — Posted on 2025-05-23
1209 Intrinsic Heterogeneity of Primary Cilia Revealed Through Spatial Proteomics
Hansen, J. N.; Sun, H.; Kahnert, K.; Westenius, E.; Johannesson, A.; Villegas, C.; Le, T.; Tzavlaki, K.; Winsnes, C.; Pohjahnen, E.; Maekiniemi, A.; Fall, J.; Navarro, F. B.; Backstrom, A.; Lindskog, C.; Johansson, F.; von Feilitzen, K.; Vega, A. D.; Casals, A. M.; Mahdessian, D.; Uhlen, M.; Sheu, S.-H.; Lindstrand, A.; Axelsson, U.; Lundberg, E.
10.1101/2024.10.20.619273 — cell biology — Posted on 2025-05-23
1210 The biomolecular profiles of extracellular vesicles from odontogenic stem cell lines depict donor-dependent differences and emphasize their therapeutic and regenerative potential
Xu, Y.; Sarisoy, A.; Buhl, E. M.; Salviano-Silva, A.; Gonzalez Rubio, J.; Thiebes, A. L.; Fuest, S.; Smeets, R.; Ricklefs, F. L.; Apel, C.
10.1101/2025.05.13.653575 — cell biology — Posted on 2025-05-23
1213 Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders
Espinoza, D. A.; Zrzavy, T.; Breville, G.; Thebault, S.; Marefi, A.; Mexhitaj, I.; Yamashita, L. D.; Kan, M.; Bacchus, M.; Legaspi, J.; Fernandez, S.; Melamed, A.; Stubblebine, M.; Kim, Y.; Martinez, Z.; Diorio, C.; Schulte-Mecklenbeck, A.; Wiendl, H.; Rezk, A.; Li, R.; Narula, S.; Waldman, A.; Hopkins, S. E.; Banwell, B.; Bar-Or, A.
10.1101/2025.02.27.637541 — immunology — Posted on 2025-05-23
1214 Microstructural and geochemical evidence offers a solution to the cephalopod cameral deposits riddle
Pohle, A.; Hoffmann, R.; Nützel, A.; Seuss, B.; Aubrechtova, M.; Kröger, B.; Stevens, K.; Immenhauser, A.
10.1101/2025.02.25.639475 — paleontology — Posted on 2025-05-23
1215 Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation
Ibikunle, C. O.; Xue, C.; Kim, E.; Yan, H.; Coronel, J.; Zhu, L. Y.; Cui, J.; Chung, A.; Bauer, R. C.; Sachs, N.; Maegdefessel, L.; Li, M.; Tall, A. R.; Bashore, A. C.; Reilly, M.
10.1101/2025.05.20.655228 — molecular biology — Posted on 2025-05-23
1217 CD200R1 is required for the development of γδ 17 T cells
Linley, H.; Jaigirdar, S.; Buckingham, L.; Cox, J.; Priestley, M.; Hains, A.; Saunders, A.
10.1101/2025.05.19.654867 — immunology — Posted on 2025-05-23
1218 Actionable biological programs to enhance EGFR-targeted therapy response unveiled by single-cell lineage tracing in clinically relevant lung cancer models
Gini, B.; Tamaki, W.; Yu, J. X.; Barbosa, D.; Wu, W.; Pourmoghadam, Y.; Allegakoen, P.; Kim, D.; Miglani, S.; Elmes, S.; Olivas, V.; Goodarzi, H.; Bivona, T. G.
10.1101/2025.05.19.654081 — cancer biology — Posted on 2025-05-23
1219 Polar organization of H&E dyes in histology tissue revealed by polarimetric nonlinear microscopy
Maciulis, M.; Mazeika, V.; Kontenis, L.; Tokarz, D.; Cisek, R.; Bulotiene, D.; Karabanovas, V.; Barzda, V.
10.1101/2025.05.19.654795 — biophysics — Posted on 2025-05-23
1220 Substrate heterogeneity promotes cancer cell dissemination
Dunajova, Z.; Tasciyan, S.; Majek, J.; Merrin, J.; Sahai, E.; Sixt, M.; Hannezo, E.
10.1101/2025.05.20.655037 — biophysics — Posted on 2025-05-23
1222 Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.
Mondal, M.; Swetman, W. S.; Karim, S. U.; Shrestha, S.; Davis, A. M.; Bai, F.; Huang, F.; Clemons, T. D.; Rangachari, V.
10.1101/2025.05.20.655132 — biophysics — Posted on 2025-05-23
1226 ChipNMR: Hyperpolarized NMR for non-invasive metabolic flux analysis in perfused microfluidic chips
Wareham Mathiassen, T. B.; Karlsson, M.; Sanchez-Heredia, J. D.; Wang, K.-C.; Haupt, C. R.; Jonsson, A.; Dufva, M.; Thuenauer, R.; Rose Jensen, P.
10.1101/2025.05.20.654798 — biochemistry — Posted on 2025-05-23
1231 A male-transmitted B chromosome undergoes strong meiotic drag in females
Ferree, P. M.; Cummings, J.; Garman, E.; Solomon, J.; Soriano Martinez, K.
10.1101/2025.05.20.655026 — genetics — Posted on 2025-05-23
1232 Temperature and genetic background drive mobilization of diverse transposable elements in a critical human fungal pathogen
Mackey, A. I.; Fraunfelter, V.; Shaltz, S.; McCormick, J.; Schroeder, C.; Perfect, J. R.; Feschotte, C.; Magwene, P. M.; Gusa, A. A.
10.1101/2025.05.19.654958 — genetics — Posted on 2025-05-23
1236 Rab11FIP2 controls NLRP3 inflammasome activation through Rab11b
Gravastrand, C.; Yurchenko, M.; Kristensen, S.; Skjesol, A.; Chen, C.; Iqbal, Z.; Dahlen, K. R.; Nonstad, U.; Ryan, L.; Espevik, T.; Husebye, H.
10.1101/2025.05.19.654879 — immunology — Posted on 2025-05-23
1237 Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells
Thomas, J. R.; Haub, J.; Hunecke, A.; Yu, J.; Maier, P.; Zhang, M.; Pregler, B. E. F.; Raspe, M.; Streith, S.; Schneider, M.; Pizarro, C.; Skowasch, D.; Ginhoux, F.; Toma, M.; Martin, J.; Send, T.; Schlitzer, A.
10.1101/2025.05.19.654443 — immunology — Posted on 2025-05-23
1238 Monolithic Shape-Shifting Absorbable Implants for Long-Term Contraception
Li, J.; Clark, B. G.; Khosravi, P.; Cotter, C.; Liang, J. Y.; Ling, S. R.; Su, Y.; Qi, K. J.; Codreanu, F.; D'Orio, E.; Tan, I. T.; Green, J. E.; Murawska, K.; Lopes, A.; Muller, B. N.; Hayward, A. M.; Fabian, N.; Pettinari, A.; Schmidt, K.; Laidlaw, B.; Platero, M.; Guevara, A.; Bernstock, J. D.; Owyang, S. Y.; Chai, P. R.; Langer, R.; Traverso, G.
10.1101/2025.05.18.654764 — bioengineering — Posted on 2025-05-23
1239 Automated Diet Matrix Construction for Marine Ecosystem Models Using Generative AI
Spillias, S.; Fulton, E. A.; Boschetti, F.; Bulman, C.; Strzelecki, J.; Trebilco, R.
10.1101/2025.05.18.654761 — ecology — Posted on 2025-05-23
1240 Exploring the genetic factors of nitrogen use efficiency in potato
Mendoza-Bustamante, M. A.; Jimenez-Medrano, A. N.; Soto-Sedano, J. C.; Delgado-Nino, M. C.; Magnitskiy, S.; Ligarreto-Moreno, G. A.; Mosquera Vasquez, T.
10.1101/2025.05.18.654744 — genetics — Posted on 2025-05-23
1243 Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38-beta activation
Bernardo, E.; Matesanz, N.; Torres, J. L.; Herrera-Melle, L.; Leiva-Vega, L.; Mora, A.; Rodriguez, M. E.; Hernandez-Cosido, L.; Nogueiras, R.; Arthur, S.; Nebreda, A. R.; Davis, R. R.; Marcos, M.; Sabio, G.
10.1101/2025.05.19.654793 — molecular biology — Posted on 2025-05-23
1244 Identification and optimization of trans-species reactive TfR1-binding VHH as tools for drug delivery across the blood brain barrier
David, M.; Cohen, R.; Beuzelin, D.; Ferracci, G.; Cresci, M.; Faucon, A.; Bakloul, K.; Godefroy, G.; Masse, M.; Mechioukhi, Y.; Girard, S. D.; Julien-Gau, I.; Boursery, C.; Fraisier, C.; Varini, K.; Thomas, M.; Jacquot, G.; Lecorche, P.; Serrano, B.; Romette, A.; Dangla Pelissier, G.; Godard, M.; Saillant, V.; Pruvost, T.; Sierocki, R.; Chames, P.; Kerfelec, B.; Temsamani, J.; KHRESTCHATISKY, M.
10.1101/2025.05.23.649291 — neuroscience — Posted on 2025-05-23
1245 Common pitfalls during model specification in psychophysiological interaction analysis
He, V.; Tahayori, B.; Vaughan, D. N.; Pardoe, H. R.; Jackson, G. D.; Tailby, C.; Abbott, D. F.; for the Australian Epilepsy Project Investigators,
10.1101/2025.05.22.655642 — neuroscience — Posted on 2025-05-23
1247 Immune stromal components impede biological effectiveness of carbon ion therapy in a preclinical model of pancreatic ductal adenocarcinoma
Swancutt, K. L.; Elghonaimy, E. A.; Nicholson, J. H.; Pop, L. M.; Siskh, B. J.; Polsdofer, E. M.; Hamilton, C.; Ruseck, A.; Davis, A. J.; Hannan, R.; Story, M. D.; Aguilera, T. A.
10.1101/2025.05.17.654632 — cancer biology — Posted on 2025-05-23
1253 Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients
Briggs, J. K.; stroh, j. n.; Park, S.; Foreman, B.; Tymko, M.; Carr, J.; Sirlanci, M.; Ainslie, P.; Benninger, R. K.; Bennett, T. D.; Albers, D. J.
10.1101/2025.05.22.655581 — bioengineering — Posted on 2025-05-23
1255 Developmental constraints mediate the summer solstice reversal of climate effects on European beech bud set
Rebindaine, D.; Crowther, T. W.; Renner, S. S.; Wu, Z.; Zou, Y.; Mo, L.; Ma, H.; Bucher, R.; Zohner, C. M.
10.1101/2025.05.18.654771 — ecology — Posted on 2025-05-23
1256 The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis
Chen, X.; Li, H.; Deng, Y.; Meng, J.; Zhao, S.; Wooton-Kee, C. R.; Gao, X.; Dong, B.; Guan, D.; Scherer, P. E.; Zhu, Y.
10.1101/2025.05.19.654778 — molecular biology — Posted on 2025-05-23
1257 Intra-tumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ DC1 infiltration and activates anti-tumor immunity
Gorline, L.; Rosa do Carmo, F.; Bourdely, P.; Borneres, J.; Vaudiau, N.; Semervil, A.; Vetillard, M.; Ok, A.; Fiquet, O.; Andrade, M.; Theobald, H.; Collin, M.; Calmette, J.; Anselmi, G.; Fico, F.; Ginhoux, F.; Saveanu, L.; Helft, J.; Dalod, M.; Dusseaux, M.; Di Santo, J. P.; Hugues, S.; Guermonprez, P.
10.1101/2025.05.19.654717 — immunology — Posted on 2025-05-23
1262 Physical principles of phase-separation action on chromatin looping associated to pathogenic gene activation
Guha, S.; Fontana, A.; Abraham, A.; Bianco, S.; Esposito, A.; Conte, M.; Kundu, S.; Di Carluccio, C.; Vercellone, F.; Di Pierno, F.; Nicodemi, M.; Chiariello, A. M.
10.1101/2025.05.20.654944 — biophysics — Posted on 2025-05-23
1270 De novo sequencing of complex glycans by ion mobility-mass spectrometry using a self-expanding reference database
Sastre Torano, J.; Vreugdenhil, J.; Vos, G. M.; Hooijschuur, K.; Vogelaar, S.; Klein, C.; Fjeldsted, J.; Stahl, B.; Boons, G.-J.
10.1101/2025.05.20.655041 — biochemistry — Posted on 2025-05-23
1271 Immune cell type divergence in a basal chordate
Scully, T. D.; Pickett, C. J.; Gort-Freitas, N. A.; Davidson, B.; Klein, A. M.
10.1101/2025.05.20.655184 — evolutionary biology — Posted on 2025-05-23
1272 Vitamin A is necessary for acquisition, but not for expression or progression, of CNS autoimmunity
Horai, R.; Zhou, R.; Bing, S. J.; Wloka, K.; Jittayasothorn, Y.; Duncan, T. E.; Mattapallil, M. J.; Silver, P. B.; Chan, C.-C.; Caspi, R. R.
10.1101/2025.05.18.654726 — immunology — Posted on 2025-05-23
1278 Viral infection induces oxylipin chemical signaling at the end of a summer upwelling bloom: implications for carbon cycling.
Edwards, B. R.; Thamatrakoln, K.; Kranzler, C. F.; Ossolinski, J.; Fredricks, H.; Johnson, M. D.; Krause, J. W.; Bidle, K. D.; Van Mooy, B.
10.1101/2025.05.18.654734 — ecology — Posted on 2025-05-23
1279 Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury
Harris, Z.; Korde, A.; Khoury, J.; Manning, E.; Stanley, G.; Mitchell, K.; Sun, Y.; Hu, B.; Shin, H. J.; Joerns, J.; Clark, B.; Placek, L.; Unutmaz, D.; Chun, H.; Sharma, L.; Sauler, M.; Rajagopalan, G.; Zhang, X.; Wang, H.; Kang, M.-J.; Koff, J.
10.1101/2024.05.24.595621 — cell biology — Posted on 2025-05-23
1280 The Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery.
Ramirez Moreno, M.; Cooper, A. S.; Lian, T.; Abtahi, S.; Liu, J. S.; Skoulakis, E. M.; Sivanantharajah, L.; Allan, D. W.; Mudher, A.
10.1101/2025.05.21.655273 — neuroscience — Posted on 2025-05-23
1282 Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking
Peters, K. Z.; Pedan, Z.; Agbude, R.; Woods, E. C.; Steele, O. G.; Suto, N.; Kinghorn, S. B.; Tsaponina, O.; Koya, E.
10.1101/2025.05.21.655312 — neuroscience — Posted on 2025-05-23
1283 CNVPipe: An enhanced pipeline for accurate analysis of copy number variation from whole-genome sequencing
Sun, J.; Wong, N. K.; Jiang, Z.; Luk, H.-M.; Lo, F. M.; Di, D.; Zhang, S.; Wong, R. C.; Jin, W.; Yip, S. P.; Huang, C.-L.
10.1101/2025.05.18.654763 — systems biology — Posted on 2025-05-23
1284 Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in Drosophila
Kosakamoto, H.; Okada, R.; Barker, C.; Seita, J.; Dohmae, N.; Imami, K.; Obata, F.
10.1101/2025.05.18.654697 — physiology — Posted on 2025-05-23
1287 Life-history trade-offs explain local adaptation in Arabidopsis thaliana
Brachi, B.; Filiault, D.; Pisupati, R.; Dahan, T.; Igolkina, A.; Anastasio, A.; Box, M. S.; Duncan, S.; Karasov, T.; Kerdaffrec, E.; Merwin, L.; Morton, T.; Nizhynska, V.; Novikova, P. Y.; Rabanal, F. A.; Tsuchimatsu, T.; Sall, T.; Dean, C.; Holm, S.; Bergelson, J.; Nordborg, M.
10.1101/2025.05.18.654693 — genetics — Posted on 2025-05-23
1288 Rescuing Ischemic Brain Injury by Rewiring Mitochondrial Electron Flow
Yoval-Sanchez, B.; Guerrero, I.; Sosunov, S.; Chen, Q.; Ansari, F.; Siragusa, M.; Konrad, C.; Niatsetskaya, Z.; Stepanova, A.; Starkov, A.; Khruschev, S.; Magrane, J.; Nikitina, A. A.; Bereshchenko, O.; Witting, I.; Zhou, P.; Zhou, L.; Szibor, M.; Manfredi, G.; Gross, S.; Ten, V.; Galkin, A.
10.1101/2025.05.19.650489 — biochemistry — Posted on 2025-05-23
1290 Aromatic Microbial Metabolite Hippuric Acid Potentiates Pro-Inflammatory Responses in Macrophages through TLR-MyD88 Signaling and Lipid Remodeling
Mirji, G.; Bhat, S. A.; El Sayed, M.; Reiser, S. K.; Gavara, S. P.; Ye, Y.; Miyamoto, T.; Liu, Q.; Goldman, A. R.; Kossenkov, A.; Zhang, N.; Shinde, R. S.
10.1101/2025.05.19.654724 — immunology — Posted on 2025-05-23
1291 From Structure to Immunogenicity: Decoding Correlated Dynamics atthe Peptide MHC interface to Understand TCR Recognition
Resink, T.; Sala, B. M.; Sun, R.; Han, X.; Alici, E.; Salazar-Onfray, F.; Sandalova, T.; Zhang, C.; Ljunggren, H.-G.; Achour, A.
10.1101/2025.05.18.654692 — immunology — Posted on 2025-05-23
1292 Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment
Adeshakin, A. O.; Shi, H.; Perry, S. S.; Sheppard, H.; Nguyen, P.; Sun, X.; Zhou, P.; Metais, J.-Y.; Cunningham, T.; KC, A.; Tian, L.; Peche, V.; Prater, M. S.; Langfitt, D. M.; Pruett-Miller, S. M.; Yustein, J. T.; Krenciute, G.; DeRenzo, C.; Chi, H.; Gottschalk, S.
10.1101/2025.05.20.650777 — immunology — Posted on 2025-05-23
1293 Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics
Patil, M. J.; Hooper, J. S.; Kim, S.-H.; Bahia, P. K.; Pavelkova, N.; Nair, S. S.; Darcey, T. S.; Lurye, K. V.; Madaram, M.; Fiallo, J.; Hadley, S. H.; Taylor-Clark, T. E.
10.1101/2025.05.18.654723 — physiology — Posted on 2025-05-23
1294 Cargo recognition of Nesprin-2 by the dynein adapter Bicaudal D2 for a nuclear positioning pathway that is important for neuronal migration
Putta, S.; Rodriguez Castro, E. D.; Ali, M. Y.; Garcia Martin, J. M.; Zhao, X.; Sylvain, S.; Trybus, K. M.; Solmaz, S. R.
10.1101/2025.05.18.654709 — biophysics — Posted on 2025-05-23
1298 The Bacterial Methylorubrum extorquens Product TS201 Induces Multiple Modes of Action to Reduce Insect Feeding Damage on Maize
Huynh, M.; Ho, K.-V.; Phillips, A.; Ernwall, A.; Ludwick, D.; Finke, D.; Lei, Z.; Jack, A.; Hibbard, B.; Breakfield, N.
10.1101/2025.05.22.655610 — plant biology — Posted on 2025-05-23
1300 An ancient plant symbiotic fungus with distinct features identified through advanced fluorescence and Raman imaging
Strullu-Derrien, C.; Wightman, R.; McDonnell, L. P.; Evans, G.; Fercoq, F.; Kenrick, P.; Ferrari, A. C.; Schornack, S.
10.1101/2025.05.22.655410 — plant biology — Posted on 2025-05-23
1302 Genome editing of papaya using both Cas9 and Cas12a
Hasley, J.; Dinulong, R.-J.; Adhikari, A.; Christopher, D.; Tian, M.
10.1101/2025.05.22.655363 — plant biology — Posted on 2025-05-23
1303 Scaling law links plant growth variation to grain yield in wheat stands
Golan, G.; Vasseur, F.; Huang, Y.; Tan, K.; Sadras, V.; violle, c.; Schnurbusch, T.
10.1101/2025.05.19.654792 — plant biology — Posted on 2025-05-23
1307 Cryo-EM structure of plant urea transporter DUR3 reveals essential role of C-terminal domain in tetramer assembly and insights into proton-coupled transport
Wang, Y.; Green, M. N.; Lin, H.; Mazurek, C.; Lin, X.; Li, T.; Wang, R.; Li, W.; Zhao, X.; Feng, P.; Frommer, W. B.; Zhang, J.; Wudick, M. M.; Fan, M.
10.1101/2025.05.20.653754 — plant biology — Posted on 2025-05-23
1308 Genetic Gains from Sixty Years of Spring Wheat Breeding in the Northern Plains of the US
Gill, H. S.; Blecha, S.; Brault, C.; Glover, K.; Green, A.; Cook, J.; Lorenz, A.; Read, A. C.; Anderson, J. A.
10.1101/2025.05.21.655386 — plant biology — Posted on 2025-05-23
1309 Energy trade-offs under fluctuating light govern bioenergetics and growth in Chlamydomonas reinhardtii
Pfleger, A.; Arc, E.; Zhang, S.; Chaturvedi, P.; Antoine, E.; Gnaiger, E.; Ghatak, A.; Afjehi-Sadat, L.; Weckwerth, W.; Kranner, I.; Roach, T.
10.1101/2025.05.19.654497 — plant biology — Posted on 2025-05-23
1310 Transcriptome Profiling of Resistance Genes Analogs in Soybean's Cross-Tolerance to Water Limitation and Rust Stress
Husein, G.; Maia, T.; Castro-Moretti, F. R.; Krugel, J. D. K.; Amorim, L.; Mazzafera, P.; Nijveen, H.; Monteiro-Vitorello, C. B.
10.1101/2025.05.20.652543 — plant biology — Posted on 2025-05-23
1311 Mechanistic dissection of Candidatus Liberibacter Triggered Chronic Immune Disease
Huang, X.; Ma, W.; Wang, W.; Feng, Y.; Lamichhane, T.; Xu, J.; Sheo, P. S.; Achor, D. S.; Li, J.; Wang, Y.; Dalmendray, J. L.; Hu, Z.; Ribeiro, C.; Zhang, N.; Kunta, M.; Hansen, A. K.; Wang, N.
10.1101/2025.05.21.654963 — plant biology — Posted on 2025-05-23
1313 The "Grove-First" Framework: Starting in the Grove to Find Therapies for Huanglongbing
Heck, M. L.; Larson, N. R.; Locatelli, G.; Cochrane, E.; Coradetti, S.; Hallman, L.; Johnson, L. M.; Estes, W. C.; Makar, A.; Demirden, N.; Pitino, M.; Shatters, R. G.; Adair, R. C.; Giles, F.; Fox, J.-P.; Stuehler, D. G.; Hodge, J.; Hoffman, J.; Blake, V.; Ulysse, L.; Ramirez-Barrera, L.; McKenna, R.; Thompson, L.; Bennett, L.; Larrea-Sarmiento, A.; Olmedo-Velarde, A.; Barkee, S.; Weeks-Purdy, C.; Zambon, F.; Shende, K.; Rossi, L.; D'Elia, T.; Ritenour, M.; Scully, B. T.; Niedz, R. P.
10.1101/2025.05.22.655577 — plant biology — Posted on 2025-05-23
1315 The JAW-TCP-FUL genetic axis triggers an early reorientation of cell anisotropy to initiate and drive fertilization-dependent fruit elongation in Arabidopsis
Sharma, A. N.; G, K.; V, A.; S. S., N. S.; Perumadaraya, A. J.; Khadeeja, M.; Pradeep, D.; Basavaraju, S.; Chandra, K.; Rangarajan, A. N.; Nath, U.
10.1101/2025.05.20.655035 — plant biology — Posted on 2025-05-23
1316 m6A RNA methylation attenuates thermotolerance in Arabidopsis
Shekhawat, K.; Sheikh, A.; Nawaz, K.; Fatima, A.; Alzayed, W.; Nagaranjan, A. P.; Hirt, H.
10.1101/2025.05.22.655480 — plant biology — Posted on 2025-05-23
1317 A Chromosome-scale Reference Genome of Meloidogyne hapla reveals localized recombination hotspots enriched with Effector Proteins
Siddique, S.; Shakya, P.; Maulana, M. I.; Danchin, E.; Voogt, M. l.; van de Ruitenbeek, S. J. S.; Gimeno, J.; Taranto, A. P.; Coomer-Blundell, A.; Despot-Slade, E.; Mestrovic, N.; Mota, A. Z.; Dai, D.; Williamson, V. M.; Sterken, M. G.
10.1101/2025.05.21.654606 — plant biology — Posted on 2025-05-23
1319 MIK2 clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families
Maroschek, J.; Roesgen, Y.; Roessner, C.; Snoeck, S.; Schwechheimer, C.; Zipfel, C.; Hueckelhoven, R.
10.1101/2025.05.22.655486 — plant biology — Posted on 2025-05-23
1320 Single-cell metabolome and RNA-seq multiplexing on single plant cells
Kang, M.; Vu, A. H.; Casper, A. L.; Kim, R.; Wurlitzer, J.; Heinicke, S.; Yeroslaviz, A.; Caputi, L.; O'Connor, S. E.
10.1101/2025.05.20.655036 — plant biology — Posted on 2025-05-23
1328 Analysis of RyR2 distribution in HEK293 cells and mouse cardiac myocytes using 3D MINFLUX microscopy
Clowsley, A. H.; Meletiou, A.; Janicek, R.; Bokhobza, A. F. E.; Lucinskaite, E.; Bleuer, G.; Jansen, I.; Jones, P. P.; Louch, W. E.; Soeller, C.
10.1101/2023.07.26.550636 — physiology — Posted on 2025-05-23
1332 DynaMiCs - Dynamic cell-type deconvolution ensembles for Mapping in mixed Conditions
Seifert, N.; Engel, L.; Tauschke, J.; Sterr, T.; Demmer, J.; Mensching-Buhr, M.; Voelkl, D.; Grellscheid, S. N.; Beissbarth, T.; Goertler, F.; Zacharias, H.; Altenbuchinger, M.
10.1101/2025.05.08.652868 — bioinformatics — Posted on 2025-05-23
1336 Designing DNA With Tunable Regulatory Activity Using Score-Entropy Discrete Diffusion
Sarkar, A.; Kang, Y.; Somia, N.; Mantilla, P.; Zhou, J. L.; Nagai, M.; Tang, Z.; Zhao, C.; Koo, P.
10.1101/2024.05.23.595630 — genomics — Posted on 2025-05-23
1341 Pan-African metapopulation model explains Homo sapiens genetic and morphological evolution
Padilla-Iglesias, C.; Xue, Z.; Leonardi, M.; Paijmans, J. L. A.; Colucci, M.; Hovhannisyan, A.; Maisano-Delser, P.; Blanco-Portillo, J.; Ioannidis, A. G.; Lucarini, G.; Cerasoni, J. N.; Kandel, A. W.; Will, M.; Hallett, E. Y.; Lupo, K.; Scerri, E. M. L.; Crevecoeur, I.; Vinicius, L.; Migliano, A. B.; Manica, A.
10.1101/2025.05.22.655514 — evolutionary biology — Posted on 2025-05-23
1342 Ancient convergence with prokaryote defense and recent adaptations to lentiviruses in primates characterize the ancestral immune factors SAMD9s
Legrand, A.; Demeure, R.; Chantharath, A.; Rey, C.; Baltenneck, J.; Gilchrist, C. L.; Rocha, J. L.; Loyer, C.; Picard, L.; Cimarelli, A.; Steinegger, M.; Rousset, F.; Sudmant, P.; Etienne, L.
10.1101/2025.05.19.654893 — evolutionary biology — Posted on 2025-05-23
1343 Ghrelin and Mboat4 are lost in Serpentes
Pinto, R.; Ruivo, R.; Stiller, J.; Oliveira, D.; Castro, F.; da Fonseca, R.
10.1101/2025.05.18.653663 — evolutionary biology — Posted on 2025-05-23
1344 Genomic Insights into Derived Dwarfism and Exudivory in a Genus (Callithrix) of the World's Smallest Anthropoid Monkeys
Malukiewicz, J.; Boere, V.; Curi, N. H.; Dergam, J. A.; Igayara, C. S.; Moreira, S. B.; Nicola, P. A.; Passamani, M.; Pereira, L. C.; del Rosario, R. C. H.; Pissinatti, A.; Silva, D. L.; de Oliveira e Silva, I.; Ruiz-Miranda, C. R.; Cartwright, R. A.; Roos, C.; Stone, A. C.
10.1101/2025.05.19.654637 — evolutionary biology — Posted on 2025-05-23
1350 Implications of Endogenous Small Regulatory RNAs on Gene Silencing in Mollusks
Von Eiff, C.; Zancanela, B. S.; Gima, M.; Quito, K.; Kotikalapudi, M.; Valdivia, S.; Santos-Ortega, Y.; Flynt, A. S.
10.1101/2025.05.19.654968 — evolutionary biology — Posted on 2025-05-23
1352 Herbarium specimens reveal a constrained seasonal climate niche despite diverged annual climates across a wildflower clade
Bontrager, M.; Worthy, S. J.; Cacho, N. I.; Leventhal, L.; Maloof, J.; Gremer, J. R.; Schmitt, J.; Strauss, S. Y.
10.1101/2025.02.28.640808 — ecology — Posted on 2025-05-23
1355 Deletion of the moe A gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism
Escobar Doncel, A.; Patinios, C.; Campos, A.; Walter Costa, M. B.; Turkina, M. V.; Murace, M.; Staals, R. H. J.; Vignolini, S.; Dutilh, B. E.; Ingham, C.
10.1101/2025.01.13.632688 — microbiology — Posted on 2025-05-23
1358 Decomposition of retinal ganglion cell electrical images for cell type and functional inference
Wu, E. G.; Rudzite, A. M.; Bohlen, M. O.; Li, P. H.; Kling, A.; Cooler, S.; Rhoades, C. E.; Brackbill, N.; Gogliettino, A. R.; Shah, N. P.; Madugula, S. S.; Sher, A.; Litke, A. M.; Field, G. D.; Chichilnisky, E. J.
10.1101/2023.11.06.565889 — neuroscience — Posted on 2025-05-23
1359 Early Indirect Neurogenesis transitions to late Direct Neurogenesis in mouse cerebral cortex development
Cardenas, A.; Celik, I.; Espinos, A.; Streicher, C.; Lopez-Gonzalez, L.; Del Valle Anton, L.; Fernandez, V.; Amin, S.; Negri, E.; Fernandez Ortuno, E.; Hippenmeyer, S.; Borrell, V.
10.1101/2025.05.22.655488 — neuroscience — Posted on 2025-05-23
1366 Parallel adaptation and admixture drive the evolution of virulence in the grapevine downy mildew pathogen
DVORAK, E.; DUMARTINET, T.; MAZET, I. D.; CHATAIGNER, A.; Paineau, M.; CANTU, D.; MESTRE, P.; FOULONGNE-ORIOL, M.; DELMOTTE, F.
10.1101/2025.05.18.654733 — plant biology — Posted on 2025-05-23
1367 RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription
Ayad, N. G.; Jangde, N.; Lee, M. H.; Ruiz, L.; Egan, I.; Jermakowicz, A.; Wynn, D.; Goka, E.; Lippman, M.; Robbins, D. J.
10.1101/2025.05.22.655563 — pharmacology and toxicology — Posted on 2025-05-23
1370 3D Biomimetic Liver Cancer Model: Diethylnitrosamine-Induced Proteomic Dysregulations in Stromal-Epithelial Milieu
Salihah, S.; Bibi, B.; Khan, S.; Tahir, M.; Mahmood, S.; Vosough, M.; Razzoli, A.; Sidoli, S.; Gul, A.
10.1101/2025.05.17.654447 — cancer biology — Posted on 2025-05-22
1375 NIR Phosphorescent Oxygen Sensors in Natural Hydrogel Matrices
Saleem, W.; Jeevarathinam, A. S.; Lindblade, R. E.; McShane, M. J.
10.1101/2025.05.17.654688 — bioengineering — Posted on 2025-05-23
1376 Comparing analytical protocols for identifying causes of population changes
Malinowska, K.; Wawrzynowicz, M.; Markowska, K.; Chodkiewicz, T.; Butler, S.; Kuczynski, L.
10.1101/2025.05.17.654658 — ecology — Posted on 2025-05-22
1377 High-severity fires undermine resilience of black spruce-dominated boreal forests in eastern North America
Fortin, S.; Boucher, Y.; Bergeron, Y.; Simard, M.; Arseneault, D.; Asselin, H.; Barette, M.; Danneyrolles, V.; Gauthier, S.; Girard, F.; Girardin, M.; Parisien, M.-A.; Thiffault, N.; Valeria, O.
10.1101/2025.05.17.654490 — ecology — Posted on 2025-05-23
1378 Worldwide spread of Hylurgus ligniperda (Coleoptera: Scolytinae), and the potential role of bridgehead invasions
Brockerhoff, E. G.; Schläfli, L.; Cornejo, C.; Kappeler, J.; Orbach, J.; Tiefenbacher, A.; Kupper, Q.; Avtzis, D.; Branco, M.; Carnegie, A. J.; Chase, K. D.; Corley, J.; Faccoli, M.; Gilbride, E.; Hurley, B. P.; Jactel, H.; Kerr, J. L.; Kirichenko, N. I.; Knizek, M.; Lakatos, F.; Lantschner, V.; Martinez, G.; Meurisse, N.; Poisson, M. A.; Poloni, A.; Rassati, D.; Riba-Flinch, J. M.; Ribeiro-Correia, J. P.; Shi, J.; Smith, D.; Somers, L.; Yuan, Y.; Prospero, S.
10.1101/2025.05.17.654641 — ecology — Posted on 2025-05-23
1379 A novel role for UPF1 in safeguarding DNA replication in S phase and beyond.
Walne, T.; Maple, L.; Li, N.; Christie, I. N.; Smythe, C.; Thompson, R. H.
10.1101/2025.05.22.655556 — cell biology — Posted on 2025-05-22
1380 Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli
Gresko, N. P.; Padovano, V.; Berg, P. M.; Ong, A. C. M.; Somlo, S.; Scholz, N.; Langenhan, T.; Caplan, M. J.
10.1101/2025.05.21.655326 — cell biology — Posted on 2025-05-22
1382 Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids
Kaur, G.; Crawford, S. E.; Ramani, S.; Ayyar, B. V.; Boussattach, A. I.; Zeng, X.-L.; Atmar, R. L.; Nguyen-Phuc, H.; Coarfa, C.; Estes, M. K.
10.1101/2025.05.22.655571 — microbiology — Posted on 2025-05-22
1385 Pneumococcal H2O2 Reshapes Mitochondrial Function and Reprograms Host Cell Metabolism
Scasny, A.; Alibayov, B.; Hoang, N. H.; Vidal, A. G.; Takeshita, K.; Bengten, E.; Baez, A.; Li, W.; Hosler, J.; Warncke, K.; Edwards, K. S.; Vidal, J. E.
10.1101/2025.05.22.655446 — microbiology — Posted on 2025-05-22
1386 Inhibitory activities of monoclonal antibodies against Staphylococcus aureus Clumping factor A
Banerjee, B.; Emolo, C.; Shi, M.; Al Fardan, A.; Pius, T.; McAdow, M.; Schneewind, O.; Missiakas, D.
10.1101/2025.05.21.655433 — microbiology — Posted on 2025-05-22
1389 CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes
Barman, S.; Räuber, S.; Eisenhut, K.; Esser, D.; van Duijn, M.; Scharf, M.; Herrera-Rivero, M.; Disse, P.; Jonas, M.; Pul, D.; Heming, M.; Müller-Miny, L.; Paunovic, M.; Strippel, C.; Haholu, E.; Kaufmann, E.; Dargvainiene, J.; Kahl, S.; Ringelstein, M.; Bindels, E.; Wiendl, H.; Stoecklein, N. H.; Fischer, J.; Goebels, N.; Komorowski, L.; Roden, M.; Rossi, A.; Stoll, M.; Meuth, S. G.; Titulaer, M. J.; Leypoldt, F.; Meyer zu Hörste, G.; Thaler, F.; Melzer, N.
10.1101/2025.05.18.654720 — immunology — Posted on 2025-05-22
1390 Meta-analytic evidence for distinct neural correlates of conditioned vs. verbally induced placebo analgesia
Spisak, T.; Hartmann, H.; Zunhammer, M.; Kincses, B.; Wiech, K.; Wager, T. D.; Bingel, U.; Placebo Imaging Consortium,
10.1101/2025.05.21.655287 — neuroscience — Posted on 2025-05-22
1392 Three-dimensional single-particle reconstruction by atomic force microscopy allows rapid structural-based validation of recombinant SARS-CoV-2 Spike protein from a single topology image
Lutter, L.; Beal, D. M.; Stanley, M.; Roobol, J.; Martin, S.; Budge, J. D.; Lee, P. E.; Nemoto-Smith, E.; Brown, I.; Warren, M. J.; Smales, C. M.; Xue, W.-F.
10.1101/2025.05.20.655128 — biophysics — Posted on 2025-05-22
1395 Detection and genetic characterization of pigeon gammacoronavirus
Kobayashi, H.; Kishimoto, M.; Imai, S.; Orba, Y.; Sawa, H.; Horie, M.
10.1101/2025.05.22.655467 — microbiology — Posted on 2025-05-22
1397 PMA-qPCR: ACCELERATING THE MARKET RELEASE OF HIGH-QUALITY BRADYRHIZOBIUM DIAZOEFFICIENS INOCULANTS
Cap, M.; Frydman, C.; Galinanes, A.; Aranguiz, C.; Faranco, I.; Andriolo, L.; Parreno, V.; Mozgovoj, M.
10.1101/2025.05.22.655534 — microbiology — Posted on 2025-05-22
1398 A conserved region T-cell vaccine for Sarbecoviruses
Escarra-Senmarti, M.; Brockhurst, J.; Maxwell, a. R.; Godwin, t.; Zhang, t.; Chen, y.; Um, P. K.; Danilova, L.; Hsu, W.-c.; Lin, C. T.; Hanke, T.; Bishai, W. R.; Pekosz, A.; Brayton, C.; Korber, B.; rosario, M.
10.1101/2025.05.20.654373 — immunology — Posted on 2025-05-22
1399 Peptide Barcodes for miRNA activity assessment in mammalian cells
Cheras, V.; Rousounelou, E.; Aschenbach, J.-L.; Panke, S.; Benenson, Y.
10.1101/2025.05.22.655559 — synthetic biology — Posted on 2025-05-22
1400 Postural test to differentiate primary aldosteronism from low-renin hypertension
Tizianel, I.; Pagin, E.; Ragazzi, E.; Madinelli, A.; Censi, S.; Sabbadin, C.; Mantero, F.; Mian, C.; Barbot, M.; Antonelli, G.; Ceccato, F.
10.1101/2025.05.16.654625 — physiology — Posted on 2025-05-22
1401 The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice
Falvey, A.; Palandira, S. P.; Chaudhry, S.; Tynan, A.; Consolim-Colombo, F. M.; Metz, C. N.; Brines, M.; Chang, E. H.; Chavan, S. S.; Tracey, K. J.; Pavlov, V. A.
10.1101/2025.05.17.654675 — physiology — Posted on 2025-05-22
1406 Decomposing Predictive Information in Social Dynamics
Kawano, A.; O'Shaughnessy, L.; Neiman, R.; Deligkaris, K.; Rodriguez, L. C.; Masai, I.; Stephens, G. J.
10.1101/2025.05.16.654393 — biophysics — Posted on 2025-05-22
1407 Endosome transcriptomics reveal trafficking of Cajal bodies into multivesicular bodies
Singh, J.; Williams, J. K.; Elliott, Q.; Jhawar, R.; Ferguson, L.; Collins, K.; Schekman, R.
10.1101/2025.05.22.655499 — biochemistry — Posted on 2025-05-22
1408 Turbulence orchestrates actin-mitochondria dynamics to preserve GPIbα and support iPSC-derived platelet biogenesis
Nakamura, E.; Harada, Y.; Nakamura, S.; Fujio, K.; De Wispelaere, K.; Thys, C.; Freson, K.; Yamamoto, T.; Sawaguchi, A.; Suetsugu, S.; Eto, K.
10.1101/2025.05.22.655481 — cell biology — Posted on 2025-05-22
1411 Cetacean coronavirus spikes highlight S glycoprotein structural plasticity
Hulswit, R. J. G.; Shamorkina, T. M.; van der Lee, J.; Rosman, F.; Wetzels, L. S.; van Kuppeveld, F. J. M.; Snijder, J.; Bosch, B. J.; Hurdiss, D. L.
10.1101/2025.05.20.655071 — microbiology — Posted on 2025-05-22
1412 Separability of antibacterial and membranolytic activity in the human host defense peptide LL-37
Albin, J. S.; Vithanage, D. A.; Vuong, W.; Johnson, C.; Yonker, L. M.; Pentelute, B. L.
10.1101/2025.05.22.655608 — microbiology — Posted on 2025-05-22
1413 The EPS-I exopolysaccharide transforms Ralstonia wilt pathogen biofilms into viscoelastic fluids for rapid dissemination in planta
Cope-Arguello, M.; Li, J.; Konkel, Z.; Aoun, N.; Cowell, T.; Wagner, N.; Chan, A. L. H.; Chu, L. T.; Wang, S.; Carter, M. D.; Allen, C.; Caverly, L. J.; Bui, L.; DeAngelis, K. M.; Wargo, M. J.; Tran, T. M.; Jacobs, J. M.; Manikantan, H.; Lowe-Power, T. M.
10.1101/2025.05.22.655385 — microbiology — Posted on 2025-05-22
1416 Age-dependent gut microbiota dynamics and their association with male fitness traits in Drosophila melanogaster
Sultanova, Z.; Dönertas, H. M.; Hita, A.; Aguilar, P.; Dag, B.; Lucas-Lledo, J. I.; Latorre, A.; Carazo, P.
10.1101/2025.05.22.655607 — microbiology — Posted on 2025-05-22
1417 Penicillium hordei acidification precipitates Bacillus subtilis lipopeptides to evade inhibition
Vertot, M.; Schostag, M. D.; Andersen, A. J.; Frisvad, J. C.; Lozano-Andrade, C. N.; Jarmusch, S. A.
10.1101/2025.05.21.655424 — microbiology — Posted on 2025-05-22
1419 WITHDRAWN:The NIH BRAIN Initiative's Experiment in Team Research
Bader, F.; David, K. K.; Lantz, C.; Rangel-Gomez, M.; Gebrehiwet, H.; Peng, G. C. Y.; Gnadt, J.
10.1101/2025.02.07.635683 — neuroscience — Posted on 2025-05-22
1423 Network-based representation learning reveals the impact of age and diet on the gut microbial and metabolomic environment of U.S. infants in a randomized controlled feeding trial
Price, A.; Rasolofomanana Rajery, S.; Manpearl, K.; Robertson, C. E.; Krebs, N. F.; Frank, D. N.; Krishnan, A.; Hendricks, A. E.; Tang, M.
10.1101/2024.11.01.621627 — microbiology — Posted on 2025-05-22
1428 ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy
Johnson, R. M.; Wang, S.; Carozza, J. A.; Fernandez, D.; Scicinski, J.; Verity, N. A.; Mardjuki, R.; Cao, X.; Papkoff, J.; Ray, N.; Li, L.
10.1101/2025.05.18.654655 — cancer biology — Posted on 2025-05-22
1431 Draft genome and transcriptomic sequence data of three invasive insect species
Lombaert, E.; Klopp, C.; Blin, A.; Annonay, G.; Iampietro, C.; Lluch, J.; Sallaberry, M.; Valiere, S.; Poloni, R.; Joron, M.; Deleury, E.
10.1101/2024.12.02.626401 — genomics — Posted on 2025-05-22
1432 New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster
Rai, M.; Okah, P.; Shefali, S. A.; Fitt, A. J.; Shen, M. Z.; Molomjamts, M.; Pepin, R.; Nemkov, T.; D'Alessandro, A.; Tennessen, J.
10.1101/2025.03.27.645621 — genetics — Posted on 2025-05-22
1433 Phylogenomic analyses reveal that Panguiarchaeum is a clade of genome-reduced Asgard archaea within the Njordarchaeia
Huang, W.-C.; Probst, M.; Hua, Z.-S.; Szantho, L. L.; Szollosi, G. J.; Ettema, T.; Rinke, C.; Williams, T. A.; Spang, A.
10.1101/2025.02.13.637844 — evolutionary biology — Posted on 2025-05-22
1434 Bona fide hematopoietic stem cells in zebrafish originate from the supra-intestinal artery
Feng, S.; Qu, R.; He, Y.; Huang, T.; Wang, Y.; Trinh, T. H.; Cheng, K.; Zhao, S.; Huang, Y.; Zhu, H.; He, S.; Wen, Z.
10.1101/2025.05.20.655066 — developmental biology — Posted on 2025-05-22
1436 Investigating Factors Driving Shifts in Subtype Dominance within H5Nx Clade 2.3.4.4b High-Pathogenicity Avian Influenza viruses
Billington, E.; Di Genova, C.; Warren, C. J.; Thomas, S. S.; Johnson, S.; Riccio, S.; De Silva, D.; Peers-Dent, J.; Temperton, N. J.; da Costa, K.; Byrne, A. M. P.; Airey, M.; Schlachter, A.-L.; Yang, J.; Nunez, A.; Iqbal, M.; Slomka, M. J.; Brown, I. H.; Banyard, A. C.; James, J.
10.1101/2025.04.23.650244 — microbiology — Posted on 2025-05-22
1438 BRAPH 2: a flexible, open-source, reproducible, community-oriented, easy-to-use framework for network analyses in neurosciences
Chang, Y.-W.; Zufiria-Gerboles, B.; Gomez-Ruiz, P. E.; Canal-Garcia, A.; Zhao, H.; Mijalkov, M.; Braga Pereira, J.; Volpe, G.
10.1101/2025.04.11.648455 — neuroscience — Posted on 2025-05-22
1440 Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors
Niederau, P. A.; Weilguny, M. C.; Chamas, S.; Turney, C. E.; Parsons, J.; Rodriguez-Franco, M.; Hoernstein, S. N. W.; Decker, E. L.; Toft Simonsen, H.; Reski, R.
10.1101/2025.02.06.636855 — plant biology — Posted on 2025-05-22
1442 BMI-1 Modulation and Trafficking During M Phase in Diffuse Intrinsic Pontine Glioma
Umaru, B.; Mishra, D.; Senthil Kumar, S.; Pang, H.-H.; Devine, B.; Khan, K.; Drissi, R.
10.1101/2025.05.16.654605 — cancer biology — Posted on 2025-05-22
1443 Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer
Wang, X.; Duan, M.; Su, P.-L.; Li, J.; Krull, J.; Jin, J.; Chen, H.; Sun, Y.; Wu, W.; He, K.; Carpenter, R.; Zhang, C.; Cao, S.; Xu, D.; Wang, G.; Li, L.; Xin, G.; Carbone, D. P.; Li, Z.; Ma, Q.
10.1101/2025.05.16.654579 — bioinformatics — Posted on 2025-05-22
1445 EYE-Llama, an in-domain large language model for ophthalmology
haghighi, t.; Gholami, S.; Sokol, J. T.; Kishnani, E.; Ahsaniyan, A.; Rahmanian, H.; Hedayati, F.; Leng, T.; Alam, M. N.
10.1101/2024.04.26.591355 — bioengineering — Posted on 2025-05-22
1448 Alternatives to Friction Coefficient: Fine Touch Perception Correlates with Frictional Instabilities
Derkaloustian, M.; Bhattacharyya, P.; Ngo, T. T.; Cashaback, J.; Medina, J.; Dhong, C. B.
10.1101/2024.10.25.620351 — neuroscience — Posted on 2025-05-22
1449 Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions
Ediga, H. H.; Vemulapalli, C. P.; Sontake, V.; Patel, P. K.; Miyazaki, H.; Popov, D.; Jensen, M.; Jegga, A. G.; Huang, S. K.; Englert, C.; Schedl, A.; Gupta, N.; McCormack, F. X.; Madala, S. K.
10.1101/2025.05.17.654673 — pathology — Posted on 2025-05-22
1450 Stimulant medications affect arousal and reward, not attention
Kay, B. P.; Wheelock, M. D.; Siegel, J. S.; Raut, R.; Chauvin, R. J.; Metoki, A.; Rajesh, A.; Eck, A.; Pollaro, J.; Wang, A.; Suljic, V.; Adeyemo, B.; Baden, N. J.; Scheidter, K. M.; Monk, J.; Ramirez-Perez, N.; Krimmel, S. R.; Shinohara, R. T.; Tervo-Clemmens, B.; Hermosillo, R. J. M.; Nelson, S. M.; Hendrickson, T. J.; Madison, T.; Moore, L. A.; Miranda-Domlnguez, O.; Randolph, A.; Feczko, E.; Roland, J. L.; Nicol, G. E.; Laumann, T. O.; Marek, S. A.; Gordon, E. M.; Raichle, M. E.; Barch, D. M.; Fair, D. A.; Dosenbach, N. U. F.
10.1101/2025.05.19.654915 — neuroscience — Posted on 2025-05-22
1455 Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis
Misra, A.; Weitman, E. M.; Weitman, M.; Brook, J. R.; Rone, J. M.; Petrova, B.; Mertens, R. T.; Hwang, N.; Zambrano Vera, K.; Perrella, M. A.; Baron, R. M.; Kanarek, N.; Nowarski, R.
10.1101/2025.05.22.654748 — pathology — Posted on 2025-05-22
1458 Variation in responses to temperature across admixed genotypes of Populus trichocarpa x P. balsamifera predict geographic shifts in regions where hybrids are favored
Mead, A.; Beasley-Bennett, J. R.; Bleich, A. C.; Fischer, D. G.; Flint, S.; Golightly, J.; Klopf, S. K.; Kulbaba, M. W.; Lasky, J.; LeBoldus, J. M.; Lowry, D. B.; Mitchell, N.; Moran, E. V.; Sexton, J. P.; Sondreli, K. L.; Worthing, B. W.; Zavala-Paez, M.; Fitzpatrick, M. C.; Holliday, J. A.; Keller, S. R.; Hamilton, J. A.
10.1101/2025.05.16.654548 — evolutionary biology — Posted on 2025-05-22
1459 Mechanisms of Output Gating for visual working memory
Zhao, C.; Adekoya, T.; Horwitz, S.; Awh, E.; Vogel, E. K.
10.1101/2025.05.22.655454 — neuroscience — Posted on 2025-05-22
1465 Deconstructing natural products to develop synthetic small molecule attachment inhibitors with broad spectrum antiviral activity
Correa-Sierra, C. C.; Cameron, J.; Hosseini, S. N.; Schatz, D.; Donnelly, J.; Murrell, C. M.; Mukhtarov, F.; Colpitts, C. C.; West, F.; Schang, L. M.
10.1101/2025.05.20.655152 — microbiology — Posted on 2025-05-22
1466 Enhanced anti-nociception by novel dual antagonists for 5HT2aR and mGluR5 in preclinical models of pain
Choi, D.; Heo, H. J.; Shin, H.; Im, J.; Lee, G.; Kim, A. H.; Hur, K.-H.; Nho, Y.; Jang, C.-G.; Lee, H.
10.1101/2025.05.21.655254 — neuroscience — Posted on 2025-05-22
1468 Study buddy learning is associated with academic success in undergraduate science courses
Jones, A.; Reznik, G.; Hossain, A. R.; Dudarev, V.; Hui, B.; Belleville, P.; Williams, W.; Fussner-Dupas, E.; Enns, J. T.
10.1101/2025.05.20.655056 — scientific communication and education — Posted on 2025-05-22
1469 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Northwest Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-05-22
1473 Exploring the immune environment of glioblastoma through single-cell RNA sequencing in humanized mouse models
Takei, J.; Furudate, K.; Nagaoka-Kamata, Y.; Iwaloye, O.; Jepson, C. E.; Blucas, M. T.; Saito, K.; Welner, R. S.; Van Meir, E. G.; Kamata, M.; Osuka, S.
10.1101/2025.05.17.654526 — immunology — Posted on 2025-05-22
1474 Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease
Shakiba, S.; Haddadi, N.-S.; Afshari, K.; Lubov, J. E.; Raef, H. S.; Li, R.; Yildiz-Altay, U.; Daga, M.; Refat, M. A.; Kim, E.; Galindo de Laflin, J.; Akabane, A.; Romano, P.; Vongvirath, J.; Sherman, S.; MacDonald, E.; Strassner, J. P.; Zhang, L.; Leon, M.; Baer, C. E.; Dresser, K.; Liang, Y.; Whitley, J. B.; Skopelja-Gardner, S.; Harris, J. E.; Deng, A.; Vesely, M. D.; Rashighi, M.; Richmond, J. M.
10.1101/2024.01.05.574422 — immunology — Posted on 2025-05-22
1475 Semi-automatic Geometrical Reconstruction and Analysis of Filopodia Dynamics in 4D Two-Photon Microscopy Images
Brence, B.; Brummer, J.; Dercksen, V. J.; Ozel, M. N.; Kulkarni, A.; Wolterhoff, N.; Prohaska, S.; Hiesinger, P. R.; Baum, D.
10.1101/2025.05.20.654789 — neuroscience — Posted on 2025-05-22
1477 The neural mechanisms of fast versus slow decision-making
Nashaat, M.; Oraby, H.; Krasniqi, F.; Goh-Sauerbier, S. T.; Bosc, M.; Koerner, S.; Karayel, S.; Kepecs, A.; Larkum, M.
10.1101/2024.08.22.608577 — neuroscience — Posted on 2025-05-22
1479 Targetable BIRC5 dependency in therapy-resistant TP53 mutated acute myeloid leukemia
Mamdouh, A. M.; Lim, F. Q.; Mi, Y.; Olesinski, E. A.; Chan, C. G. T.; Jasdanwala, S.; Lin, X. X.; Wang, Y.; Tan, J. Y. M.; Bhatia, K. S.; Sapozhnikova, V.; Wang, C.; Mahesh, A. N.; Tan, D. E. L.; Chitkara, N.; Mertins, P.; Hogdal, L.; Brown, B. D.; Haferlach, T.; Lobry, C.; Lindsley, C.; Puissant, A.; Ho, H. K.; Das, S.; Letai, A.; Kornblau, S. M.; Krönke, J.; Ayoub, E.; Itahana, K.; Andreeff, M.; Bhatt, S.
10.1101/2025.05.17.654633 — cancer biology — Posted on 2025-05-22
1480 BMI-1 Modulation and Trafficking During M Phase in Diffuse Intrinsic Pontine Glioma
Umaru, B.; Mishra, D.; Senthil Kumar, S.; Pang, H.-H.; Devine, B.; Khan, K.; Drissi, R.
10.1101/2025.05.16.654605 — cancer biology — Posted on 2025-05-22
1481 Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma
Barr, T.; Jennings, V. A.; Roundhill, E. A.; Baugh, R. T.; Yamrali, M.; Owston, H.; McGonagle, D.; Giannoudis, P. V.; Caplen, N. J.; Khan, J.; Bell, J. C.; Burchill, S. A.; Errington-Mais, F.; Cook, G. P.
10.1101/2025.05.16.654440 — cancer biology — Posted on 2025-05-22
1485 Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer
Ma, Q.; Wang, X.; Duan, M.; Su, P.-L.; Li, J.; Krull, J.; Jin, J.; Chen, H.; Sun, Y.; Wu, W.; He, K.; Carpenter, R.; Zhang, C.; Cao, S.; Xu, D.; Wang, G.; Li, L.; Xin, G.; Carbone, D. P.; Li, Z.
10.1101/2025.05.16.654579 — bioinformatics — Posted on 2025-05-22
1486 Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis
Deng, Y.; Ehiogu, B.; Luca, E.; Dabdoub, A.; Le Cao, K.-A.; Wells, C.; Nayagam, B.
10.1101/2025.05.16.654631 — bioinformatics — Posted on 2025-05-22
1494 PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After Injury
Menon, A. S.; Kumaran, M.; Beji, D. S.; Kesireddy, D. K.; Sahu, Y.; Manjunath, S.; Sanyal, K.; Konda, M.; Banerjee, S.; Venkatesh, I.
10.1101/2025.05.14.654166 — neuroscience — Posted on 2025-05-22
1496 Cellular computing without bioengineering
Ahavi, P.; Hoang, A.; Meyer, P.; Berthier, S.; Fiorini, F.; Castelli, F.; Epaulard, O.; Le Gouellec, A.; Faulon, J.-L.
10.1101/2024.09.12.612674 — systems biology — Posted on 2025-05-22
1498 Microbially-mediated halogenation and dehalogenation cycling of organohalides in the ocean
Zhou, N.; Li, Q.; Liang, Z.; Yu, K.; Zhang, C.; Wang, H.; Li, P.; He, Z.; Wang, S.
10.1101/2025.05.17.654656 — ecology — Posted on 2025-05-21
1501 Primary auditory cortex is necessary for the acquisition and expression of categorical behavior
Krall, R. F.; Cassidy, R. M.; Ghimire, M.; Chambers, C. N.; Arnold, M. P.; Brougher, L. I.; Chen, J.; Deshmukh, R.; King, H. B.; Morford, H. J.; Wiemann, J. M.; Williamson, R. S.
10.1101/2024.02.02.578700 — neuroscience — Posted on 2025-05-21
1502 Estimating fMRI Timescale Maps
Riegner, G.; Davenport, S.; Voytek, B.; Schwartzman, A.
10.1101/2025.04.23.650300 — neuroscience — Posted on 2025-05-21
1503 Aligning Neural Population Patterns Facilitates Motor Learning Transfer
Zhang, X.; Song, Z.; Shen, X.; Chen, S.; Huang, Y.; Principe, J.; Wang, Y.
10.1101/2025.05.16.654614 — neuroscience — Posted on 2025-05-21
1504 PYEAST - Python Enabled Automated Strain Transformation
Madika, A.; Suri, A.; Purohit, A.; Van Raad, D.; Norman, M.; Hartley, C.; Loan, T. D.
10.1101/2025.05.19.655004 — synthetic biology — Posted on 2025-05-21
1505 Tumoral hypoxic extracellular vesicles foster a protective microenvironment in triple-negative breast cancer
Pachane, B. C.; Bottaro, P. H. T.; Machado, A. M.; Castro, C. A.; Guerra, G.; Gozzer, L. T.; Grigoli, M. M.; Zutiao, A. D.; Fuzer, A. M.; Cominetti, M. R.; Altei, W. F.; Selistre-de-Araujo, H. S.
10.1101/2024.11.01.621519 — cancer biology — Posted on 2025-05-21
1509 Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation
Fodera, D. M.; Xu, E. Z.; Duarte-Cordon, C. A.; Wyss, M.; Fang, S.; Chen, X.; Oyen, M. L.; Rosado-Mendez, I.; Hall, T.; Vink, J.; Feltovich, H.; Myers, K. M.
10.1101/2024.11.17.624020 — bioengineering — Posted on 2025-05-21
1511 Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding
Jing, T.; Shan, Z.; Dinh, T.; Biswas, A.; Jang, S.; Greenwood, J.; Li, M.; Zhang, Z.; Gray, G.; Shin, H. J.; Zhou, B.; Passos, D.; Strutzenberg, T. S.; Aiyer, S.; Andrade, L.; Li, Z.; Craigie, R.; Engelman, A. N.; Kvaratskhelia, M.; Lyumkis, D.
10.1101/2024.01.26.577436 — biochemistry — Posted on 2025-05-21
1514 Modeling the acutely injured brain environment in vitro.
Maria Arzate, D.; Alvaro, V.; Pradanos-Senen, A. V.; Gallego, L.; Manzano-Franco, D.; Llorente-Saez, C.; Bartolome-Cabrero, R.; Ferrarini, A.; Lopez, J. A.; Murenu, E.; Berninger, B.; Ortega, F.; Goetz, M.; Heinrich, C.; Gascon, S.
10.1101/2025.01.08.631921 — neuroscience — Posted on 2025-05-21
1519 The recombination landscape of Drosophila melanogaster can be repatterned by a single gene
Hughes, S. E.; Staber, C.; McKown, G.; Yu, Z.; Blumenstiel, J. P.; Hawley, R. S.
10.1101/2025.05.16.654569 — genetics — Posted on 2025-05-21
1522 Intralysosomal pathogens differentially influence the proteolytic potential of their niche
Bird, L. E.; Xu, B.; McGowan, E. N. S.; Newton, P.; Scott, N. E.; McConville, M. J.; Edgington-Mitchell, L.; Newton, H. J.
10.1101/2025.05.21.655381 — microbiology — Posted on 2025-05-21
1525 Fragment Screening by Weak Affinity Chromatography Identifies Ligands for Neisseria gonorrhoeae Undecaprenyl Diphosphate Synthase
Santiago, A. d. S.; Amaral, B. S.; Llontopp, E.; Ramos, P. Z.; Souza, L. R.; Cunha, M. R.; Piccirillo, E.; Almeida, V. M.; Pilli, R. A.; Barreiro, G.; Massirer, K. B.; Counago, R. M.
10.1101/2025.05.21.654962 — microbiology — Posted on 2025-05-21
1526 Long-term Reprogramming and Altered Ontogeny of Classical Monocytes Mediates Enhanced Lung Injury in Sepsis Survivor Mice
Denstaedt, S. J.; McBean, B.; Boyle, A. P.; Arenberg, B. C.; Mack, M.; Moore, B. B.; Newstead, M. W.; Singer, B. H.; Cano, J.; Prescott, H. C.; Goodridge, H. S.; Zemans, R. L.
10.1101/2025.05.16.654442 — immunology — Posted on 2025-05-21
1527 Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease
Zhang, L.; Yasumizu, Y.; Deerhake, M. E.; Moon, J.; Buitrago-Pocasangre, N.; Russo, A.; Wang, H.; Zhu, B.; Seibyl, J. P.; Reddy, V.; Wang, Q.; Spillantini, M. G.; Posner, D. A.; Clatworthy, M.; Sumida, T. S.; Longbrake, E. E.; Cedarbaum, J. M.; Hafler, D. A.
10.1101/2025.05.16.654530 — immunology — Posted on 2025-05-21
1529 Comparison of QuPath and HALO platforms for analysis of the tumor microenvironment in prostate cancer
zhang, w.; Zhou, Q.; Nguyen, J. V.; Egal, E.; Yang, Q.; Freeman, M. R.; Hu-Lieskovan, S.; Suneja, G.; Coghill, A.; Knudsen, B. S.
10.1101/2025.05.16.654590 — pathology — Posted on 2025-05-21
1530 The Splicing Factor PTBP1 interacts with RUNX1 and is Required for Leukemia Cell Survival
Dhir, A.; Ethell, A.; Watkins, R.; Lam, C.; Tur-Rodriguez, K.; Persinger, J.; Dobish, K. K.; Panda, S.; Buckley, S. M.; Swenson, S. A.; Brahma, S.; Rowley, M. J.; Hyde, R. K.
10.1101/2025.05.16.654547 — cancer biology — Posted on 2025-05-21
1531 Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI
Chang, K.; Serasanambati, M.; Ogunlade, B.; Hsu, H.-J.; Agolia, J. P.; Stiber, A.; Gu, J.; Sharma, S.; Chadokiya, J.; Goncalves, A.; Safir, F.; Vu, N.; Delitto, D. J.; Kirane, A. R.; Dionne, J. A.
10.1101/2025.05.16.654612 — cancer biology — Posted on 2025-05-21
1532 EGR1 drives sex-differences in glioblastoma tumorigenicity
Abou-Antoun, T.; Llaci, L.; Wong, J. P.; Yang, L.; Warrington, N. M.; Tripp, L.; Luo, J.; Muegge, B.; Rubin, J. B.; Mitra, R. D.
10.1101/2025.05.16.654616 — cancer biology — Posted on 2025-05-21
1535 Mechanism-driven screening of membrane-targeting and pore-forming antimicrobial peptides
Li, J.; Yang, C.; Dong, R.; Bada Juarez, J. F.; Wang, L.; Wettstein, M. E.; Wang, D.; Cao, C.; Lu, Y.; Song, C.
10.1101/2025.05.17.654650 — biophysics — Posted on 2025-05-21
1540 Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase
Pang, E. Z.; Zhao, B.; Flowers, C.; Oroudjeva, E.; Winter, J. B.; Pandey, V.; Sawaya, M. R.; Wohlschlegel, J.; Loo, J. A.; Rodriguez, J. A.; Clarke, S. G.
10.1101/2025.05.21.654933 — biochemistry — Posted on 2025-05-21
1541 Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
Shaw, S.; Li, X.; Buenconsejo, G. Y.; Tiffany, Z. H.; Cohen, A.; Yasur, D.; Xiao, R.; Beiting, D. P.; Anderson, T. J.; Striepen, B.
10.1101/2025.05.20.655157 — genetics — Posted on 2025-05-21
1547 Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics
Ayyar, B. V.; Apostol, C. V.; Dave, J.; Kaundal, S.; Neill, F. H.; Ettayebi, K.; Maher, S.; Anish, R.; Larson, G.; Atmar, R. L.; Crawford, S. E.; Prasad, B. V. V.; Estes, M. K.
10.1101/2025.05.20.655000 — microbiology — Posted on 2025-05-21
1548 The tiniest genomes shrink much further: extreme reductive evolution in planthopper symbionts
Michalik, A.; Castillo Franco, D.; Deng, J.; Prus-Frankowska, M.; Stroinski, A.; Lukasik, P.
10.1101/2025.05.16.654412 — evolutionary biology — Posted on 2025-05-21
1550 Long-Term Ecological Baselines and Critical Thresholds in Ombrotrophic Peatlands of Europe: Implications for Restoration Strategies
Draga, M.; Gałka, M.; Knorr, K.-H.; Glatzel, S.; Chojnicki, B.; Fritz, C.; Jassey, V.; Juszczak, R.; Meyer, H.; Robroek, B.; Thomas, C.; Lamentowicz, M.
10.1101/2025.05.16.654541 — ecology — Posted on 2025-05-21
1553 Disturbed engram network caused by NPTXs downregulation underlies aging-related memory deficits
Jin, T.; Yang, Y.; Guo, Y.; Zhang, Y.; Le, Q.; Huang, N.; Liu, X.; Yu, J.; Ma, L.; Wang, F.
10.1101/2025.05.19.654996 — neuroscience — Posted on 2025-05-21
1557 Heavy Metal Exposure Disrupts Electrotactic Behavior in Caenorhabditis elegans
Taylor, S. K. B.; Minhas, M. H.; Tong, J.; Selvaganapathy, P. R.; Mishra, R. K.; Gupta, B. P.
10.1101/2025.05.20.655158 — animal behavior and cognition — Posted on 2025-05-21
1559 The Human Insula Encodes Somatotopic Representation of Motor Execution with an Effector-Specific Connectomic Map to Primary Motor Cortex
Kerezoudis, P.; Jensen, M. A.; Klassen, B. T.; Worrell, G. A.; Gregg, N. M.; Ince, N. F.; Hermes, D.; Miller, K. J.
10.1101/2025.05.19.653527 — neuroscience — Posted on 2025-05-21
1560 Brain Multi-Omic Subtypes of Neuroticism Reveal Molecular Signatures linked to Alzheimer's Disease
Zammit, A. R.; Lopes, K. d. P.; Batalha, C. M. P. F.; Yu, L.; Poole, V. N.; Tasaki, S.; Kapasi, A.; Wang, Y.; De Jager, P. L.; Menon, V.; Seyfried, N.; Kaddurah-Daouk, R.; Iturria-Medina, Y.; Bennett, D. A.
10.1101/2025.05.19.654904 — neuroscience — Posted on 2025-05-21
1561 Intercellular communication in the brain via dendritic nanotubular network
Chang, M.; Kruessel, S.; Parajuli, L. K.; Kim, J.; Lee, D.; Merodio, A.; Kwon, J.; Okabe, S.; Kwon, H.
10.1101/2025.05.20.655147 — neuroscience — Posted on 2025-05-21
1562 Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain
Butler, P. M.; Francis, A.; Meunier, A. L.; Anderson, A. K.; Hennessey, E. L.; Miller, M. B.; Lemere, C. A.; Selkoe, D. J.; Stern, A. M.
10.1101/2025.05.20.654902 — neuroscience — Posted on 2025-05-21
1563 Accelerating Neuron Reconstruction with PATHFINDER
Januszewski, M.; Templier, T.; Hayworth, K. J.; Peale, D.; Hess, H.
10.1101/2025.05.16.654254 — neuroscience — Posted on 2025-05-21
1565 Development of noninvasive imaging to measure spontaneous pain in mice
Yuan, S.; Liew, J. Y.; Pal, A.; Wang, J.; Green, D. P.; Motamedi, M.; Tang, S.-J.
10.1101/2025.05.20.655170 — neuroscience — Posted on 2025-05-21
1568 Large Scale Cell Painting Guided Compound Selection Reveals Activity Cliffs and Functional Relationships
Sanchez, M.; Bourriez, N.; Bendidi, I.; Cohen, E.; Svatko, I.; Del Nery, E.; Tajmouati, H.; Bollot, G.; Calzone, L.; Genovesio, A.
10.1101/2025.05.16.654292 — bioinformatics — Posted on 2025-05-21
1570 Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity
Domen, J.; Voskoboynik, Y.; Levy, T.; Domen, E. M.; Ishizuka, K. j.; Palmeri, K. j.; Anselmi, C.; Rolander, T.; Neff, N. F.; Detweiler, A. M.; Weissman, I. L.; Gandy, K. L.; Sahoo, D.; Voskoboynik, A.
10.1101/2025.05.17.654683 — developmental biology — Posted on 2025-05-21
1573 The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury
Laabei, J.; Vegliante, G.; Strogulski, N. R.; Douglas, C.; Threja, S.; Pearson, A.; Nkiliza, A.; Hanscom, M.; Filogonio Emediato, I. D.; Crawford, F.; Ojo, J.; Loane, D.
10.1101/2025.05.16.654460 — neuroscience — Posted on 2025-05-21
1575 Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide
Malange, K.; Lemes, J. B. P.; Noble, B.; Anchondo, Y.; Urbina, C. M.; Jadhav, S.; Dochnal, S. A.; Kambalimath, C.; Alvarez, P.; Fitzsimmons, B.; Mazur, C.; Kordasiewicz, H.; Dore, K.; Zhao, H.; Yaksh, T. L.
10.1101/2025.05.19.654680 — neuroscience — Posted on 2025-05-21
1577 NaviGraph
Koren Iton, A.; Iton, E.; Michaelson, D. M.; Blinder, P.
10.1101/2025.05.18.654725 — neuroscience — Posted on 2025-05-21
1579 The semantics of dreams
Elce, V.; Bontempi, G.; Scarpelli, S.; Pedreschi, B.; De Gennaro, L.; Pietrini, P.; Bellesi, M.; Bernardi, G.; Handjaras, G.
10.1101/2025.05.20.654459 — neuroscience — Posted on 2025-05-21
1584 Cell type distribution of intrathecal antisense oligonucleotide activity in deep brain regions of non-human primates
Frei, J.; Gentile, J.; Lian, Y.; Mortberg, M. A.; Capitanio, J.; Jafar-nejad, P.; Vallabh, S. M.; Zhao, H. T.; Minikel, E. V.
10.1101/2025.05.20.655163 — neuroscience — Posted on 2025-05-21
1586 Enkephalinergic Neurons Gate Sex-Specific Control of Voluntary Micturition
Klymko, N.; Sartori, A. M.; Leon, M.; Seifert, C. N.; Lee, R.; Mathai, J. C.; Verstegen, A. M. J.
10.1101/2025.05.16.654570 — neuroscience — Posted on 2025-05-21
1590 Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair
Chu, C.-W.; Velayudhan, S. S.; Schauser, J. H.; Krishnakumar, S.; Yang, S.; Itoh, K.; Alfandari, D.; Trusina, A.; Sokol, S. Y.
10.1101/2025.05.20.654909 — developmental biology — Posted on 2025-05-21
1593 TRiC-assisted folding of class I HDAC family proteins regulated by distinct co-chaperone and cofactor networks
li, z.; Zhao, Q.; jiang, w.; song, q.; zhou, x.; shi, x.; zhang, q.; wang, y.; lin, y.; Yin, Y.; pan, c.; Cong, Y.
10.1101/2025.05.21.655272 — molecular biology — Posted on 2025-05-21
1594 3D organoids containing endothelial and neural cells generation by serial inductions of differentiation on human iPSC-derived embryoid bodies
Wang, T.; Bagnell, A.; McDonald, V.; Gastfriend, B. D.; Steiner, J. P.; Elkahloun, A. G.; Johnson, K.; Langston, R. G.; Cookson, M. R.; Nath, A.
10.1101/2025.05.20.653559 — neuroscience — Posted on 2025-05-21
1595 Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults
Fischer, L.; Adams, J. N.; Molloy, E. N.; Tremblay-Mercier, J.; Remz, J.; Pichet Binette, A.; Rajah, M. N.; Villeneuve, S.; Maass, A.; PREVENT-AD Research Group,
10.1101/2025.05.16.654628 — neuroscience — Posted on 2025-05-21
1596 Exploring the association between walking, sleep patterns, brain perivascular spaces, and cognitive function in Parkinson's disease
Sibilia, F.; Barisano, G.; Fotouhi, M.; Loehrer, P. A.; Wong, K.; Mack, W. J.; Lew, M.; Dafsari, H.; Choupan, J. A.
10.1101/2025.05.16.654573 — neuroscience — Posted on 2025-05-21
1601 Frequency-dependent diffusion tensor distribution imaging in the evaluation of ischemic stroke
Grohn, S.; Naranjo, A.; Narvaez, O.; Yon, M.; Buz-Yalug, B.; Blanco, S.; Topgaard, D.; Martinez-Lara, E.; Peinado, M. A.; Tohka, J.; Sierra, A.
10.1101/2025.05.19.654809 — neuroscience — Posted on 2025-05-21
1602 Absence of testes at puberty impacts functional development of nigrostriatal but not mesoaccumbal dopamine terminals in a wild-derived mouse
Mun, J.; Jackson, S. C.; Prounis, G.; Phumsatitpong, C.; Motahari, N.; Kriegsfeld, L.; Landry, M. P.; Wilbrecht, L.
10.1101/2025.05.16.654596 — neuroscience — Posted on 2025-05-21
1604 Youth-associated protein TIMP2 alters microglial state and function in the context of aging
Hemmer, B. M.; Ferreira, A. C.; Philippi, S. M.; Petridis, S. F.; Phan, A.; Castellano, J. M.
10.1101/2025.05.20.655226 — neuroscience — Posted on 2025-05-21
1606 DJ-1 deficiency and aging: dual drivers of retinal mitochondrial dysfunction.
Upadhyay, M.; Sturgis, J.; Bhattacharyya, S.; Jiang, K.; Hagstrom, S. A.; Bonilha, V. L.
10.1101/2025.05.19.654941 — neuroscience — Posted on 2025-05-21
1607 The anterior olfactory nucleus mediates curious exploration evoked by novel odors
De Plus, R.; Martijn, B.; Giaffar, H.; Eleonore, S.; Kondrakiewicz, K.; Aydin, C.; Haesler, S.
10.1101/2025.05.19.654779 — neuroscience — Posted on 2025-05-21
1609 Neural mechanisms for visuomotor co-regulation in social synchronization
Uccelli, S.; Sacheli, L. M.; De Bernardi, C.; Devoto, F.; Basso, G.; Paulesu, E.
10.1101/2025.05.21.655276 — neuroscience — Posted on 2025-05-21
1610 Assessing the robustness of deep learning based brain age prediction models across multiple EEG datasets
Tveitstoel, T.; Tveter, M.; Hatlestad-Hall, C.; Hammer, H. L.; Engemann, D.; Haraldsen, I.
10.1101/2025.05.20.655022 — neuroscience — Posted on 2025-05-21
1612 Distinct subtypes of astrocytes selectively regulate specific inhibitory synapses
Clarke, D.; Bosson, A.; Honore, E.; Contant, K.; Avignone, E.; Lacaille, J.-C.; Robitaille, R.
10.1101/2025.05.16.654545 — neuroscience — Posted on 2025-05-21
1615 Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation
Kriukov, E.; Mukwaya, A.; Cullen, P. F.; Baldwin, G.; Malechka, V. V.; Refaian, N.; Bagaev, N.; Labrecque, E.; Vinjamuri, S.; Margeta, M. A.; Baranov, P.
10.1101/2025.05.16.654622 — neuroscience — Posted on 2025-05-21
1617 Estradiol treatment enhances neurovascular coupling independent of metabolic health status in a mouse model of menopause
Plumley, Z. M.; Calvo Iglesias, J.; Fernandez Ugidos, I.; Walker, A. B.; Pires dos Santos, I.; Taylor, H.; Mostany, R.
10.1101/2025.05.21.655189 — neuroscience — Posted on 2025-05-21
1618 Basophils activate splenic B cells and Dendritic cells via IL-13 signaling in acute Traumatic Brain Injury
olde Heuvel, F.; Zhang, J.; Sun, F.; Krishnamurthy, S. S.; Yartas, G.; Pagliarini, M.; Schaefer, M.; Huber-Lang, M.; Roselli, F.
10.1101/2025.05.20.655028 — neuroscience — Posted on 2025-05-21
1619 Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion
Ahlgreen, O. A.; Hansen, M. W.; Baake, J.; Hybel, T. E.; Rossi, R.; Lai, X.; Sankaranarayanan, I.; Pold, J. A.; Lin, L.; Reinert, L. S.; Palludan, S. R.; Price, T. J.; Pallesen, L. T.; Vaegter, C. B.
10.1101/2025.05.19.654813 — neuroscience — Posted on 2025-05-21
1625 Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo
Amurrio, E.; Patel, J.; Danaher, M.; Elzaree, L.; Fisher, J. L.; Greene, H.; Kargbo, P.; Kim, P.; Klimentova, E.; Lin, S.; Liu, Y.; Abdella, S.; Mehboob, M. Y.; Temesgen, Y.; Mahmood, S.; Rotella, D. P.; Kelly, M.
10.1101/2025.05.20.654583 — neuroscience — Posted on 2025-05-21
1626 The Molecular Architecture of Somatic Spines of the Lateral Septum
Hacker, D.; Weisheim, E.; Schweizer, M.; Schneeweiss, U.; Brecht, M.; Mikhaylova, M.
10.1101/2025.05.19.654857 — neuroscience — Posted on 2025-05-21
1627 Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins
Duan, X.; Zhang, C.; Ott, S.; Zhang, Z.; Ruse, C.; Dannhaeuser, S.; Jacobi, R.; Ehmann, N.; Sachidanandan, D.; Nagel, G.; Heckmann, M.; Kittel, R.; Gottschalk, A.; Claridge-Chang, A.; Gao, S.
10.1101/2025.05.20.654571 — neuroscience — Posted on 2025-05-21
1630 Transcranial magnetic vs intracranial electric stimulation: a direct comparison of their effects via scalp EEG recordings
Comolatti, R.; Hassan, G.; Mikulan, E.; Russo, S.; Colombo, M.; Litterio, E.; Furregoni, G.; D'ambrosio, S.; Fecchio, M.; Parmigiani, S.; Sartori, I.; Casarotto, S.; Pigorini, A.; Massimini, M.
10.1101/2025.05.21.654985 — neuroscience — Posted on 2025-05-21
1631 Semi-automatic Geometrical Reconstruction and Analysis of Filopodia Dynamics in 4D Two-Photon Microscopy Images
Brence, B.; Brummer, J.; Dercksen, V. J.; Ozel, M. N.; Kulkarni, A.; Wolterhoff, N.; Prohaska, S.; Hiesinger, P. R.; Baum, D.
10.1101/2025.05.20.654789 — neuroscience — Posted on 2025-05-21
1634 Sex-Specific Neural Adaptations to Acute and Chronic Restraint Stress in Mice
Li, A.-J.; McGraw, M.; Landsparger, H.; Benjamin, L.; Qualls-Creekmore, E.
10.1101/2025.05.20.655203 — neuroscience — Posted on 2025-05-21
1636 Neuronal oscillations predict un-cued task switching in the Wisconsin card sorting test
Sattelberger, J.; Haque, H.; Liu, M.; Simola, J.; Palva, J. M.; Halassa, M.; Palva, S.
10.1101/2025.05.19.654819 — neuroscience — Posted on 2025-05-21
1640 Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia
Guldner, I. H.; Wagner, V. P.; Moran Losada, P.; Shi, S. M.; Chen, K.; Meese, B. T.; Oh, H.; Le Guen, Y.; Lu, N.; Wong, P. S.; To, N.-S.; Garceau, D.; Guo, Z.; Luo, J.; Sasner, M.; Keller, A.; Yang, A. C.; Cheung, T.; Wyss-Coray, T.
10.1101/2025.05.20.654652 — neuroscience — Posted on 2025-05-21
1641 Frontostriatal salience network expands as executive networks contract in Obsessive-Compulsive Disorder
Vaghi, M. M.; Norgaard, M.; Shim, S.; Rios, J. A. H.; Bissett, P. G.; Rodriguez, C. I.; Poldrack, R. A.
10.1101/2025.05.21.654808 — neuroscience — Posted on 2025-05-21
1642 The Neural Architecture of Dream Recall Frequency: Insights from Interindividual Variations in Brain Structure and Function
Pereira, M.; Galdi, P.; Mei, T.; Rutiku, R.; Mikkelsen, I. K.; Llera, A.; Scheeringa, R.; Beckmann, C.; Krause, F.; Dresler, M.; Sandberg, K.
10.1101/2025.05.20.655114 — neuroscience — Posted on 2025-05-21
1643 Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation
Wood, C. P.; Shin, Y.; Balaguer, M. G.; Campo, P.; Dirik, S.; Montoya, B. A.; Cook, G. M. R.; Palermo, G. M.; Naghshineh, P. K.; Morgan, A.; Rahman, S. R. M. U.; Palmer, A. A.; Telese, F.; de Guglielmo, G.
10.1101/2025.05.20.655167 — animal behavior and cognition — Posted on 2025-05-21
1644 Dynamics of mound repair behavior in termites
Varma Raja, S.; Vats, A.; Prasad, P.; Pandey, C. K.; Sane, S. P.
10.1101/2025.05.19.654859 — animal behavior and cognition — Posted on 2025-05-21
1645 Revisiting the habitat selection of a specialist forest bird, Scolopax rusticola, during its wintering in the Mediterranean region
Beaumelle, C.; Barbet, J.; Cuby, A.; Chautan, M.; Etienne, F.; Martel, M.; Du Roure, A.; Chabanne, R.; Lauer, E.; Le Rest, K.
10.1101/2025.05.19.654177 — animal behavior and cognition — Posted on 2025-05-21
1646 A low-cost immersive Virtual Reality system to study social interactions and collective behavior in fish
Sanchez, S.; Escobedo, R.; Bastien, R.; Denis, A.; Moreau, M.; Combe, M.; Straw, A. D.; Sire, C.; Theraulaz, G.
10.1101/2025.05.20.655100 — animal behavior and cognition — Posted on 2025-05-21
1648 Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study
Brezzo, G.; Zera, K. A.; Straus, D. E.; Goertz, J. E.; Loppi, S. H.; Crumpacker, R. R.; Frye, J. B.; Becktel, D. A.; Cuartero, M. I.; Culebras, A. G.; Dames, C.; Berchtold, D.; Fowler, J. H.; Meisel, A.; Anrather, J.; Moro, M. A.; Allan, S. M.; Doyle, K.; Buckwalter, M. S.; McColl, B. W.
10.1101/2025.05.21.655267 — animal behavior and cognition — Posted on 2025-05-21
1652 Bona fide hematopoietic stem cells in zebrafish originate from the supra-intestinal artery
Feng, S.; Qu, R.; He, Y.; Huang, T.; Wang, Y.; Trinh, T. H.; Cheng, K.; Zhao, S.; Huang, Y.; Zhu, H.; He, S.; Wen, Z.
10.1101/2025.05.20.655066 — developmental biology — Posted on 2025-05-21
1655 SOX2-VSX2 Co-Occupancy Shapes Retinal Neurogenesis Through Dynamic Chromatin Regulation
Bian, F.; Golestaneh, K.; Davis, E.; Khan, A.; Daghsni, M.; Flohr, K.; Liu, S.; da Silva, S.; Pennacchio, L.; Al Diri, I.
10.1101/2025.05.19.654956 — developmental biology — Posted on 2025-05-21
1660 Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons
Li, Z.; Kaur, N.; Santpere, G.; Muchnik, S. K.; Sindhu, S. K.; Qi, C.; Shibata, M.; Clement, O.; Klaric, T. S.; Martin, X. d.; Luria, V.; Cho, H.; Li, M.; Shibata, A.; Tebbenkamp, A. T. N.; Ma, S.; Han, W.; Kim, S. K.; Pochareddy, S.; Phan, D. Q.; Xing, X.; Bao, Y.; Xu, X.; Gladwyn-Ng, I. E.; Cullen, H. D.; Paolino, A.; Fenlon, L. R.; Kozulin, P.; Suarez, R.; Risgaard, R. D.; Gulden, F. O.; Karger, A.; Suzuki, I. K.; Hirata, T.; Gobeske, K. T.; Richards, L. J.; Sousa, A. M. M.; Heng, J. I.; Sestan, N.
10.1101/2025.05.20.652233 — neuroscience — Posted on 2025-05-21
1661 An anthropoid/strepsirrhine divergence in ventral visual stream connectivity
Hunt, J. E.; Warrington, S.; Roumazeilles, L.; Jbabdi, S.; Molnar, Z.; Sotiropoulos, S. N.; Mars, R. B.
10.1101/2025.05.19.653861 — neuroscience — Posted on 2025-05-21
1665 stFormer: a foundation model for spatial transcriptomics
Cao, S.; Yang, K.; Cheng, J.; Shen, H.-B.; Pan, X.; Yuan, Y.
10.1101/2024.09.27.615337 — bioinformatics — Posted on 2025-05-21
1668 Gene regulatory dynamics during craniofacial development in a carnivorous marsupial
Cook, L. E.; Feigin, C. Y.; Hills, J. D.; Vespasiani, D. M.; Pask, A. J.; Gallego Romero, I.
10.1101/2023.02.13.528361 — developmental biology — Posted on 2025-05-21
1669 Direct binding of arsenicals to nuclear transport factors disrupts nucleocytoplasmic transport
Lorentzon, E.; Lee, J.; Masaryk, J.; Keuenhof, K.; Karlsson, N.; Galipaud, C.; Madsen, R.; Hoog, J. L.; Levin, D. E.; Tamas, M. J.
10.1101/2025.01.13.632748 — cell biology — Posted on 2025-05-21
1670 Archaeal SegAB forms a bipolar structure that promotes chromosome segregation in spherical cells
Charles-Orszag, A.; Lord, S. J.; Herrera, N.; Strauskulage, L.; Bhowmick, A.; Goddard, T.; Wassmer, B.; van Wolferen, M.; Asper, G.; Flis, A.; Rodriguez, J.; Redding, S.; Rosenberg, O.; Albers, S.-V.; Mullins, D.
10.1101/2025.04.15.649018 — cell biology — Posted on 2025-05-21
1672 Effects of parental care on skin microbial community composition in poison frogs
Fischer, M.-T.; Xue, K. S.; Costello, E. K.; Dvorak, M.; Robaczewska, A.; Raboisson, G.; Caty, S. N.; Relman, D. A.; O'Connell, L. A.
10.1101/2024.09.11.612488 — microbiology — Posted on 2025-05-21
1674 Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats
Lalanza, J. F.; Oyem, J. C.; Huijgens, P. T.; McCutcheon, J. E.; Heijkoop, R.; Snoeren, E. M. S.
10.1101/2024.10.14.618156 — neuroscience — Posted on 2025-05-21
1676 Evolution of sensory systems underlies the emergence of predatory feeding behaviours in nematodes
Roca, M.; Eren, G. G.; Boeger, L.; Didenko, O.; Lo, W.-s.; Scholz, M.; Lightfoot, J. W.
10.1101/2025.03.24.644997 — neuroscience — Posted on 2025-05-21
1677 Cardiac-specific GCN5L1 deficiency promotes MASLD in HFpEF
Bugga, P.; Mushala, B. A.; Stoner, M. W.; Manning, J. R.; Bhattarai, N.; Sharifi-Sanjani, M.; Vandevender, A.; Mooli, R. G.; Ramakrishnan, S. K.; Kaufman, B. A.; Shiva, S. S.; Happe, C. L.; Mullett, S. J.; Gelhaus, S. L.; Jurczak, M. J.; Scott, I.
10.1101/2025.02.05.636634 — physiology — Posted on 2025-05-21
1679 Nanotopographic Control of Actin Waves and Growth Cone Navigation in Developing Neurons
Pathak, S.; O'Neill, K. M.; Robinson, E. K.; Hourwitz, M. J.; Herr, C.; Fourkas, J. T.; Giniger, E.; Losert, W.
10.1101/2025.05.16.654525 — biophysics — Posted on 2025-05-21
1685 Oncogenic drivers shape the tumor microenvironment in human gliomas
Zhao, B.; Cho, C. Y.; Ye, L.; Keal, T.; Mitchell, T. J.; Martin-Barrio, I.; Weinberg, J. S.; Huse, J. T.; Dixon, J. R.; Lang, F. F.; Akdemir, K. C.
10.1101/2025.05.16.654515 — genomics — Posted on 2025-05-21
1686 Engineering precision zebrafish alleles of human disease
Thomas, H. R.; Yoder, B. K.; Alexander, M. S.; Parant, J. M.
10.1101/2025.05.18.654701 — genetics — Posted on 2025-05-21
1688 Soft tissue constraints on joint mobility in the avian shoulder
Demuth, O. E.; Hutchinson, J. R.; La Barbera, V.; Warner, S. E.; Field, D. J.
10.1101/2025.05.16.654461 — evolutionary biology — Posted on 2025-05-21
1690 Spatial and single-nucleus transcriptomic profile of a chimpanzee frontal pole
Alagöz, G.; Wong, M.; Grässle, T.; Jäger, C.; Morawski, M.; Kolleck, J.; Francks, C.; Wittig, R. M.; Crockford, C.; Gunz, P.; Fisher, S. E.
10.1101/2025.02.16.638510 — evolutionary biology — Posted on 2025-05-21
1693 Burkholderia Genes Involved in Extracellular Bioplastic Degradation Revealed by Tn-seq and CRISPR-Cas
Yap, Z. L.; Lucas, G. G.; Safklou, M.; Darragh, R.; Hogan, A. M.; Motnenko, A.; Blunt, W.; Sparling, R.; Levin, D. B.; Fernandez Do Porto, D. A.; Cardona, S. T.
10.1101/2025.05.20.655153 — microbiology — Posted on 2025-05-21
1694 Decoupling bile acid 7α-dehydroxylation from colonization resistance to Clostridioides difficile
Beldi, L.; Dong, Y.; Volet, C.; Tandon, D.; Filipova, K.; Bernier-Latmani, R.; Hapfelmeier, S.
10.1101/2025.05.20.655077 — microbiology — Posted on 2025-05-21
1695 In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-Synucleinopathies
Fouka, M.; Tsakogias, I.; Gialinaki, E. G.; Stavropoulos, A.; Volbracht, C.; De Muynck, L.; Moechars, D.; Melki, R.; Tofaris, G.; Stefanis, L.; Xilouri, M.
10.1101/2025.05.16.653961 — neuroscience — Posted on 2025-05-21
1698 Succinate Modulation as a Novel Mechanism Underlying the Effects of Intermittent Fasting on Brain Function and Metabolism in Diet-Induced Obesity
Tognozzi, A.; Carli, F.; Abdelkarim, S.; Cornuti, S.; Damiani, F.; Giuliano, M. G.; Miniati, A.; Nasisi, M.; de Benedictis, L.; Ashtiani, K. C.; Scabia, G.; Maffei, M.; Baldi, P. F.; Gastaldelli, A.; Tognini, P.
10.1101/2025.05.16.654006 — neuroscience — Posted on 2025-05-21
1699 Weight-bearing symmetry changes after asymmetric surface stiffness walking
Price, M. A.; Schell, E.; Jaramillo, J. M.; Chiasson, J.; Metsker, L.; Huber, M. E.; Hoogkamer, W.
10.1101/2025.05.16.654517 — neuroscience — Posted on 2025-05-21
1701 Neural correlates of consciousness in an auditory no-report fMRI study
Dellert, T.; Balster, H.; Schlossmacher, I.; Bruchmann, M.; Moeck, R.; Straube, T.
10.1101/2025.05.16.654468 — neuroscience — Posted on 2025-05-21
1704 Decreased female survival may explain wild turkey decline
Lashley, M. A.; Chitwood, M. C.; Moeller, A. K.; Gulsby, W. D.; Potash, A. D.; O'Neil, K.; Turner, M.
10.1101/2025.05.16.654534 — zoology — Posted on 2025-05-21
1705 Cytoplasmic CaMKIIδ-B prevents myocardial recovery in heart failure
Martin, T. G.; Hunt, D. R.; Ebmeier, C. C.; Dhand, A. P.; Alamana, C.; Cleveland, J. C.; Graw, S. L.; Bruner, S.; Bristow, M. R.; Mestroni, L.; Taylor, M. R.; Burdick, J. A.; Ambardekar, A. V.; Buttrick, P. M.; Leinwand, L. A.
10.1101/2025.05.16.654509 — physiology — Posted on 2025-05-21
1706 From Movement to METs: A Validation of ActTrust(R) for Energy Expenditure Estimation and Physical Activity Classification in Young Adults
dos Santos Batista, E.; Basilio Gomes, S. R.; Bruno de Morais Ferreira, A.; Franca, L. G. S.; Fontenele Araujo, J.; Mortatti, A. L.; Leocadio-Miguel, M. A.
10.1101/2025.05.16.654458 — bioinformatics — Posted on 2025-05-21
1715 Off-target interaction of the amyloid PET imaging tracer PiB with acetylcholinesterase
Granzotto, A.; Fullone, R.; Miccoli, L.; Bomba, M.; Di Marzio, C.; Delli Pizzi, S.; Floresta, G.; Sensi, S. L.
10.1101/2025.05.16.654428 — neuroscience — Posted on 2025-05-21
1717 A Deep Learning approach for time-consistent cell cycle phase prediction from microscopy data
Bonte, T.; Pourcelot, O.; Safieddine, A.; Slimani, F.; Mueller, F.; Weil, D.; Bertrand, E.; Walter, T.
10.1101/2025.05.16.654306 — bioinformatics — Posted on 2025-05-21
1719 Quercetin treatments alleviate production, egg quality, blood metabolites, and anti-oxidant defence in laying hens : A meta-analysis study
Hartanto, S.; Wardono, H. P.; Kurnianto, H.; Hantoro, F. R. P.; Prasetyo, A.; Haryanto, B.; Hayati, R. N.; Ludfiani, D. D.; Purwasih, R.; Yano, A. A.; Sujiwo, J.; Jang, A.; Sugiharto, S.
10.1101/2025.05.16.654414 — animal behavior and cognition — Posted on 2025-05-21
1721 Fusion transcription factor dosage controls cell state in rhabdomyosarcoma
Hoffman, R. A.; Wang, M.; Sunkel, B. D.; Nguyen, T. H.; Lopez-Nava, J.; Chatterjee, B.; Sun, W.; Barr, F. G.; Stanton, B. Z.
10.1101/2025.05.16.654522 — genomics — Posted on 2025-05-21
1722 Progressive neuroinflammation and deficits in motor function in a mouse model with an Epg5 pathogenic variant of Vici syndrome
Thornton, B. T.; Hardinger, A. G.; Pence, L.; Prem Kumar, P.; Connolly, N.; Weir, S. J.; Vivian, J. L.
10.1101/2025.05.16.654529 — genetics — Posted on 2025-05-21
1725 Phenology and flower species availability define wild bee communities on river embankments
Swinkels, C.; Slikboer, L.; Raemakers, I.; Godijn, N.; Jongejans, E.; de Kroon, H.
10.1101/2025.05.16.653962 — ecology — Posted on 2025-05-21
1730 Western diet reversibly alters the olfactory mucosa and impairs the response to appetitive food cues
Eygret, L.; Aruci, E.; Canova, V.; Paradis, J.; Soubeyre, V.; Chomel, T.; Capoduro, R.; Grosmaitre, X.; Fioramonti, X.; Jarriault, D.
10.1101/2025.05.16.654424 — neuroscience — Posted on 2025-05-21
1731 A large 3D-printed integrated lens-biprism element enhances contrast in transmission stereomicroscopy
Rooney, L. M.; Amos, W. B.; Foylan, S.; Christopher, J.; Butterworth, C.; Bauer, R.; Gould, G. W.; McConnell, G.
10.1101/2025.05.20.655140 — biophysics — Posted on 2025-05-21
1732 Antagonism between bacteriophages and macrophages decreases efficacy of a phage cocktail and increases bacteriophage resistance
Castledine, M.; Szczutkowska, Z.; Matthews, A.; Walsh, S. K.; Lewis, R.; Kay, S.; Willment, J. A.; Brown, G. D.; Buckling, A.
10.1101/2025.05.16.654446 — evolutionary biology — Posted on 2025-05-21
1733 Inverted topographies in sequential fitness landscapes enable evolutionary control
Chen, P.; Krishnan, N.; Stacy, A.; Weaver, D. T.; Barker-Clarke, R.; Hinczewski, M.; Maltas, J.; Scott, J. G.
10.1101/2024.12.29.630702 — evolutionary biology — Posted on 2025-05-21
1735 A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species
Wang, D.; Ming, H.; Yang, D.; Tsai, L.-K.; Wei, Z.; Scatolin, G. N.; Wang, X.; Yau, K.; Tao, L.; Tong, X.; Wang, S.; Shi, K.-X.; Evseenko, D.; Handel, B. V.; Zhang, B.; Wang, Y.; Iyyappan, R.; Ojeda-Rojas, O. A.; Hu, G.; McGinnis, L.; Paulson, R.; Mckim, D.; Kong, X.; Xia, X.; Zhang, J.; Chen, E. Y.; Xu, J.; Jiang, Z.; Ying, Q.-L.
10.1101/2025.05.20.654948 — cell biology — Posted on 2025-05-21
1736 Purification protocol of hypertrophied hepatic stellate cells for their transcriptomic characterization from CDAHFD mice liver
Heckmann, M.; Djerir, N.-E.-H.; Commere, P.-H.; Fernandes, J.; Sarrabayrouse, G.; Bigey, P.; Escriou, V.; HOFFMANN, C.
10.1101/2025.05.19.654829 — cell biology — Posted on 2025-05-21
1740 Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells
Kovacs, P.; Brazda, P.; Hajdu, T.; Harsanyi, B.; Juhasz, K. Z.; Takacs, R. A.; Judit, V.; Wang, Z.; Coveney, C.; Boocock, D. J.; Matta, C.
10.1101/2025.05.19.654853 — cell biology — Posted on 2025-05-21
1741 Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific MYH9 Mutations
Llorente-Gonzalez, C.; Mustafina, K.; Talayero, V. C.; Asensio-Juarez, G.; Garrido-Casado, M.; Sellers, J. R.; Chinthalapudi, K.; Wiseman, P. W.; Heissler, S. M.; Vicente-Manzanares, M.
10.1101/2025.05.20.654665 — cell biology — Posted on 2025-05-21
1742 JAK/STAT Signaling Governs Airway Epithelial Homeostasis and Stress Resilience in Drosophila
Niu, X.; Fink, C.; Kallsen, K.; Shi, L.; Mincheva, V.; Franzenburg, S.; Prange, R. D.; Bruchhaus, I.; Heine, H.; Bossen, J. M.; Roeder, T.
10.1101/2025.05.20.655050 — cell biology — Posted on 2025-05-21
1744 Inhibition of TBK1/IKKe mediated RIPK1 phosphorylation sensitizes tumors to immune cell killing
Piskopou, A.; Vredevoogd, D. W.; Kong, X.; Altelaar, M.; Peeper, D. S.; Stecker, K. E.
10.1101/2025.05.20.655064 — cell biology — Posted on 2025-05-21
1746 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy
Li, H.; Xie, Z.; Tian, Y.; Zhou, R.; Yang, Y.; Lin, B.; Chen, S.; Wu, J.; Deng, Z.; Li, J.; Chen, M.; Liu, X.; Sun, Y.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — neuroscience — Posted on 2025-05-21
1748 The cryo-EM structure of mouse radial spoke 3 reveals a unique metabolic and regulatory hub in cilia
Zhao, Y.; Song, K.; Tavakoli, A.; Gui, L.; Fernandez Gonzalez, A.; Zhang, S.; Dzeja, P. P.; Mitsialis, S. A.; Zhang, X.; Nicastro, D.
10.1101/2025.05.19.654877 — biophysics — Posted on 2025-05-21
1750 Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis.
Perez, K. C.; Alexander, J.; Rahman, M. M.; Alsharif, H. A.; Liu, Y.; Kim, J.-A.; Hunter, C. S.; Nguyen, T. M.; Bhatnagar, S.
10.1101/2025.05.19.654959 — cell biology — Posted on 2025-05-21
1751 SPROUTS_DB: an implemented database of contaminants for extracellular vesicle proteomics studies
Pittala, M. G. G.; Leggio, L.; Paterno, G.; Giusto, E.; Civiero, L.; Cunsolo, V.; Vivarelli, S.; Di Francesco, A.; Alpi, E.; Saletti, R.; Iraci, N.
10.1101/2025.05.20.655024 — cell biology — Posted on 2025-05-21
1753 Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury
Yamamoto, M.; Ash, D.; Sudhahar, V.; Zaidi, S. A. H.; Rojas, M. A.; Xu, Z.; Kelley, S.; Caldwell, R. B.; Fukai, T.; Ushio-Fukai, M.
10.1101/2025.05.17.654687 — cell biology — Posted on 2025-05-21
1755 Unveiling the hidden window of prime editing
Chen, P.-R.; Wei, Y.; Yuan, X.-Z.; Wang, S.-G.; Xia, P.-F.
10.1101/2025.05.20.655067 — synthetic biology — Posted on 2025-05-21
1756 Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma
Barr, T.; Jennings, V. A.; Roundhill, E. A.; Baugh, R. T.; Yamrali, M.; Owston, H.; McGonagle, D.; Giannoudis, P. V.; Caplen, N. J.; Khan, J.; Bell, J. C. C.; Burchill, S. A.; Errington-Mais, F.; Cook, G. P.
10.1101/2025.05.16.654440 — cancer biology — Posted on 2025-05-21
1757 EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma
Carreno-Gonzalez, M. J.; Hanssen, K. M.; Sadik, A.; Henneberg, A.; Ehlers, A. C.; Ceranski, A. K.; Kołodynska, Z. A.; Zimmermann, M.; Imle, R.; Geyer, F. H.; Ritter, A.; Banito, A.; Knott, M. M. L.; Ohmura, S.; Cidre-Aranaz, F.; Opitz, C. A.; Grünewald, T. G. P.
10.1101/2025.05.16.654502 — cancer biology — Posted on 2025-05-21
1759 Zika and chikungunya viruses decrease salivation in Aedes aegypti mosquitoes
Souriac, L.; Berni, M.; Voisin, B.; Leite, T. H. J. F.; Marois, E.; Aubry, F.; Marques, J. T.
10.1101/2025.05.16.654423 — immunology — Posted on 2025-05-21
1760 HO-3867 mediated modulation of Extracellular vesicles and Tumor microenvironment: A novel immunotherapeutic strategy for ovarian cancer
Yadagiri, G.; Chakrapani, L. N.; Sundaram, S.; Velasquez, J.; Hughes, T.; Vendrell, G. S.; Bognar, B.; Wang, Q.-E.; O Malley, D. M.; Cohn, D. E.; Karuppaiyah, S.; Dorayappan, K. D. P.
10.1101/2025.05.16.653814 — cancer biology — Posted on 2025-05-21
1761 Kaminari: a resource-frugal index for approximate colored k-mer queries
Levallois, V.; Shibuya, Y.; Le Gal, B.; Patro, R.; Peterlongo, P.; Pibiri, G. E.
10.1101/2025.05.16.654317 — bioinformatics — Posted on 2025-05-21
1763 CROCKETA: An automated framework for comprehensive multi-omic analysis of gene expression and clonotype immune repertoire at a single-cell level
Soria Alcaide, G.; Garcia Aguilera, G.; Portasany Rodriguez, M.; Lalchandani Lakhani, J.; Gonzalez Murillo, A.; Garcia Sanchez, E.; Saiz Ladera, C.; Ramirez Orellana, M.; Garcia Martinez, J.
10.1101/2025.05.16.654451 — bioinformatics — Posted on 2025-05-21
1764 Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Lee, K. K.; Lapinska, U.; Tolle, G.; Micaletto, M.; Zhang, B.; Phetsang, W.; Verderosa, A.; Invergo, B. M.; Westley, J.; Bebes, A.; Yuecel, R.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; van Houte, S.; Caboni, P.; Blaskovich, M.; Housden, B.; Tsaneva-Atanasova, K.; Pagliara, S.
10.1101/2024.04.22.590445 — microbiology — Posted on 2025-05-21
1771 Inferring domestic goat demographic history through ancient genome imputation
Erven, J. A. M.; Etourneau, A.; Mashkour, M.; Neupane, M.; Bardou, P.; Stella, A.; Talenti, A.; Masiga, C. W.; Van Tassel, C. P.; Clark, E. L.; Pompanon, F.; Colli, L.; Amallis, M.; Milanesi, M.; Crepaldi, P.; Consortium, T. V.; Servin, B.; Rosen, B.; Tosser-Klopp, G.; Daly, K. G.
10.1101/2025.04.18.649576 — genomics — Posted on 2025-05-21
1772 Clonal Hematopoiesis Mutations Increase Risk of Alzheimer's Disease with APOE ϵ3/ϵ3 Genotype
Choi, J.; Park, K. S.; Le Guen, Y.; Park, J.-H.; Zhou, Z.; Enyenihi, L.; Rosen, I.; Choi, Y.-H.; Walsh, C. A.; Kim, J.-W.; Huang, A. Y.; Lee, E. A.
10.1101/2025.05.19.654981 — genetics — Posted on 2025-05-21
1774 Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development
Panasenkava, V.; Garreau, J.; Guyodo, H.; Diab, F.; Mahieux, A.; Carre, W.; Verres, Y.; Jullion, E.; Odent, S.; Dubourg, C.; Rollier, P. R.; Dubos, L.; RIBES, V.; Camus, A.; Tayrac, M.; Dupe, V.
10.1101/2025.05.20.654466 — developmental biology — Posted on 2025-05-21
1776 Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification.
Van der Snickt, T.; Ailliet, S.; Bassini, S.; Peymen, A.; Colaker, A.; Cadoni, E.; Valverde, A.; Daems, E.; Madder, A.; De Wael, K.; Mestdagh, P.; SOCan consortium,
10.1101/2025.05.19.654176 — molecular biology — Posted on 2025-05-21
1777 Clinical, Biological and Pathological Investigation of Bovine Lymphocyte Intestinal Retention Deficit (BLIRD): a new genetic disorder affecting life expectancy and immunity in Holstein dairy cattle
DUTHEIL, L. M. L.; Gausseres, B. B.; Besnard, F. F.; Guzylack-Piriou, L. L.; Abdou Monsef, Y. Y.; Gaide, N. N.; Arnalot, L. L.; Corbiere, F. F.; Gaborit, M. M.; Launay, F. F.; Poujade, A. A.; Capitan, A. A.; Foucras, G. G.
10.1101/2025.05.18.654695 — immunology — Posted on 2025-05-21
1778 Stimulant medications affect arousal and reward, not attention
Kay, B. P.; Wheelock, M. D.; Siegel, J. S.; Raut, R.; Chauvin, R. J.; Metoki, A.; Rajesh, A.; Eck, A.; Pollaro, J.; Wang, A.; Suljic, V.; Adeyemo, B.; Baden, N. J.; Scheidter, K. M.; Monk, J.; Ramirez-Perez, N.; Krimmel, S. R.; Shinohara, R. T.; Tervo-Clemmens, B.; Hermosillo, R. J. M.; Nelson, S. M.; Hendrickson, T. J.; Madison, T.; Moore, L. A.; Miranda-Domlnguez, O.; Randolph, A.; Feczko, E.; Roland, J. L.; Nichol, G. E.; Laumann, T. O.; Marek, S. A.; Gordon, E. M.; Raichle, M. E.; Barch, D. M.; Fair, D. A.; Dosenbach, N. U. F.
10.1101/2025.05.19.654915 — neuroscience — Posted on 2025-05-21
1779 Differential expression of spatiotemporal sleep spindle clusters in ageing
Raud, L.; Smits, M. J. B.; Sneve, M. H.; Ness, H. T.; Folvik, L.; Rasch, B.; Fjell, A. M.
10.1101/2025.05.19.654222 — neuroscience — Posted on 2025-05-21
1780 Differential Effects of Meditation States and Traits on the Neural Mechanisms of Pain Processing
Kolev, V.; Malinowski, P.; Raffone, A.; Nicolardi, V.; Simione, L.; Aglioti, S. M.; Yordanova, J.
10.1101/2025.05.20.655049 — neuroscience — Posted on 2025-05-21
1783 PYEAST - Python Enabled Automated Strain Transformaiton
Madika, A.; Suri, A.; Purohit, A.; Van Raad, D.; Norman, M.; Hartley, C.; Loan, T. D.
10.1101/2025.05.19.655004 — synthetic biology — Posted on 2025-05-21
1785 Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats
Zuarth Gonzalez, J. D.; Ragsdale, A. K.; Mukhopadhyay, S.; McCurdy, C. R.; McMahon, L. R.; Obeng, S.; Wilkerson, J. L.
10.1101/2025.05.16.654392 — pharmacology and toxicology — Posted on 2025-05-21
1786 Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection
Phan, J. R.; Bacab, E.; Washington, M.; Niamba, M.; Do, D. M.; Mata, T. V.; Consul, A.; Blank, L.; Yang, S.; Howerton, A. J.; Heredia, E.; Soriano, R.; Hassan, C.; Cross, C. L.; Abel-Santos, E.
10.1101/2023.07.05.547871 — microbiology — Posted on 2025-05-21
1791 Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division
Li, J.; He, Y.; Xu, X.; Alcorlo, M.; Shi, J.; Naskar, S.; Briggs, N.; Roper, D. I.; A. Hermoso, J.; Sham, L.-T.; Luo, M.
10.1101/2024.01.16.575974 — microbiology — Posted on 2025-05-21
1793 The Role of Chloride Ions in Serotonin Transport
Huang, J.; Backer, A.; Uchendu, S.; Bekele, B.; Chen, Q.; Orabi, E.; Stix, R.; Zhang, Y.-W.; Rudnick, G.; Hellsberg, E.; Forrest, L. R.
10.1101/2025.05.20.654092 — biochemistry — Posted on 2025-05-20
1795 Epstein-Barr virus and Helicobacter pylori Coinfection Drives Gut and Brain Barrier Dysfunction
Jha, H. C.; Saini, V.; Singh, S.; Baral, B.; Sinha, P.; Singh, A.; Gaudin, R.; Parmar, H. S.
10.1101/2025.05.20.655045 — microbiology — Posted on 2025-05-20
1797 Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth
Shappell, H.; Liu, Z.; Khodaei, M.; He, G.; Gee, D.; Lindquist, M.; Sukhodolsky, D. G.; McCarthy, G.; Ibrahim, K.
10.1101/2025.05.15.654366 — neuroscience — Posted on 2025-05-20
1801 Rational Design and Modeling of Auxetic Fiber Scaffolds for Soft Tissue Engineering via Melt Electrowriting
Lecina-Tejero, O.; Iamsamang, J.; Alaman-Diez, P.; Garcia-Gareta, E.; Cuartero, J.; Perez, M. A.; Castilho, M.; Borau, C.
10.1101/2025.05.15.654200 — bioengineering — Posted on 2025-05-20
1805 Extensive richness and novel taxa of sulfoquinovose-degrading bacteria in the cow rumen
Krasenbrink, J.; Chen, S.-C.; Tanabe, T. S.; Sarikece, H.; Meurs, P.; Borusak, S.; Samrat, R.; Osvatic, J.; Seneca, J.; Hausmann, B.; Speth, D. R.; Selberherr, E.; Wanek, W.; Schleheck, D.; Mussmann, M.; Loy, A.
10.1101/2025.05.20.655074 — microbiology — Posted on 2025-05-20
1807 Graphene Micro-transistor Arrays Reveal Perfusion-Dependent Electrophysiological and Haemodynamic Signatures of Cortical Spreading Depolarizations in Ischaemic Stroke
Flaherty, S. M.; Eladly, A.; Hills, K. E.; Merlini, J. E.; Masvidal-Codina, E.; Fernandez, E.; Illa, X.; Prats-Alfonso, E.; del Corro, E.; Garrido, J. A.; Kostarelos, K.; Allan, S. M.; Guimera-Brunet, A.; Wykes, R.
10.1101/2025.05.15.654197 — neuroscience — Posted on 2025-05-20
1808 Breathing strategies to influence perception: Evidence for interoceptive and exteroceptive active sensing
della Penna, F.; Zaccaro, A.; Bayram, B.; Bubbico, F.; Perrucci, M. G.; Costantini, M.; Ferri, F.
10.1101/2025.05.15.654033 — neuroscience — Posted on 2025-05-20
1811 A Reductive Uric Acid Degradation Pathway in Anaerobic Bacteria
Li, Z.; Meng, W.; Gao, Z.; Peng, W.; Zhang, J.; Wang, Y.; Wu, X.; Zhao, Z.; Zhang, C.; Tang, Z.; Nie, Z.; Wu, S.; Wu, B.; Tong, Y.; Hu, Y.; Hu, Z.; Wei, Y.; Zhang, Y.
10.1101/2025.05.19.654654 — biochemistry — Posted on 2025-05-20
1817 Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening
Casas, A.; Imlay, L. S.; Thathy, V.; Deni, I.; Lehane, A. M.; Lawong, A. K.; Fairhurst, K. J.; Striepen, J.; Lee, S.; Kumar, A.; Xing, C.; Niederstrasser, H.; Posner, B. A.; Laleu, B.; Charman, S. A.; Fidock, D. A.; Ready, J. M.; Phillips, M. A.
10.1101/2025.05.20.655166 — microbiology — Posted on 2025-05-20
1818 Specialist Generalist Trade Offs in Microbial Growth Rates Across Soil Habitats
Foley, M.; Sokol, N.; Stone, B.; Blazewicz, S. J.; Estera-Molina, K.; Greenlon, A.; Hayer, M.; Kimbrel, J.; Pett-Ridge, J.; Hungate, B. A.
10.1101/2025.05.20.655198 — microbiology — Posted on 2025-05-20
1819 AGPAT1 is a novel Chikungunya virus receptor on human cells
Basu, B.; Sarmadhikari, D.; Asthana, S.; Kalia, M.; Vrati, S.
10.1101/2025.05.20.655106 — microbiology — Posted on 2025-05-20
1820 Chemical activity profiling reveals how exposure to drugs or dietary compounds alters gut microbial biotransformation capacity
Bigonne, H.; Zhai, S.; Folz, J.; Hurley, K.; Murali, A.; Zickgraf, F. M.; Kamp, H.; van Ravenzwaay, B.; Aichinger, G.; Sturla, S. J.
10.1101/2025.05.20.655107 — microbiology — Posted on 2025-05-20
1821 Sub-phenotypes of pneumonia defined by pulmonary histopathological features
Shastry, A.; Hiller, B. E.; Sanders, N. L.; Tseng, A. E.; Kothari, J.; O'Connell, A. K.; Gertje, H. P.; Ha, C. T.; Murzin, E.; Traber, K. E.; Lederer, J. A.; Jones, M. R.; Douam, F.; Beach, T. G.; Remick, D. G.; Crossland, N. A.; Monti, S.; Campbell, J. D.; Mizgerd, J. P.
10.1101/2025.05.18.654716 — immunology — Posted on 2025-05-20
1822 The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse
Sicorello, M.; Gianaros, P. J.; Wright, A. G. C.; Petre, B.; Kraynak, T.; Manuck, S.; Schmahl, C.; Wager, T. D.
10.1101/2025.05.15.653674 — neuroscience — Posted on 2025-05-20
1823 Evaluating the dependence of ADC-fMRI on haemodynamics inbreath-hold and resting-state conditions
de Riedmatten, I.; Spencer, A. P. C.; Nguyen-Duc, J.; Perot, J.-B.; Szczepankiewicz, F.; Esteban, O.; Jelescu, I. O.
10.1101/2025.05.15.654237 — neuroscience — Posted on 2025-05-20
1825 Aperiodic slope reflects glutamatergic tone in the human brain
Sheldon, A. A.; Moser, H. R.; Abdullahi, K. S.; Allison, K. D.; Mulder, C. B.; Montoya, S. A.; Sponheim, S. R.; Marjanska, M.; Schallmo, M.-P.
10.1101/2025.05.15.654118 — neuroscience — Posted on 2025-05-20
1827 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging
Amaral, M. L.; Mamde, S.; Miller, M.; Hou, X.; Arzavala, J.; Osteen, J.; Walker Smoot, E.; Yang, Q.; Eisner, E.; Zeng, Q.; Baez-Becerra, C. T.; Olness, J.; Kern, J. C.; Rink, J.; Johnson, N.; Barcoma, A.; Cho, S.; Cao, S.; Emerson, N.; Lee, J.; Willier, J.; Loe, T.; Jiao, H.; Zu, S.; Zhu, Q.; Preissl, S.; Wang, A.; Ecker, J.; Behrens, M. M.; Ren, B.
10.1101/2025.04.21.649585 — genomics — Posted on 2025-05-20
1830 GPU-accelerated homology search with MMseqs2
Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.
10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-05-20
1833 Improvement of human donor retinal ganglion cell survival through modulation of microglia
Malechka, V. V.; Phay, M. H.; Augustine, J.; Kriukov, E.; Rivera, J. D.; Alt, C.; Gregory-Ksander, M.; Baranov, P.
10.1101/2024.07.06.602307 — cell biology — Posted on 2025-05-20
1834 Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling
Guzman, S. D.; Abu-Mahfouz, A.; Davis, C. S.; Ruiz, L. P.; Macpherson, P. C.; Brooks, S. V.
10.1101/2023.10.06.561193 — neuroscience — Posted on 2025-05-20
1837 The NIH BRAIN Initiative Impacts in Systems and Computational Neuroscience and Team-Scale Research, 2014-2023
Bader, F.; Bingham, C.; David, K. K.; Gebrehiwet, H.; Lantz, C.; Peng, G. C. Y.; Rangel-Gomez, M.; Gnadt, J.
10.1101/2025.01.30.635684 — neuroscience — Posted on 2025-05-20
1839 Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke
Cottarelli, A.; Jamoul, D.; Tuohy, M. C.; Shahriar, S.; Glendinning, M.; Prochilo, G.; Edinger, A.; Arac, A.; Agalliu, D.
10.1101/2023.08.29.555373 — cell biology — Posted on 2025-05-20
1841 Efficient profiling of total RNA in single cells with STORM-seq
Johnson, B. K.; Majewski, M.; Jang, H. J.; Siwicki, R. A.; Wegener, M.; Semwal, A.; Morrison, J.; Gallik, K. L.; Hagemann-Jensen, M.; Foy, K.; Rossell, L. L.; Siegwald, E. J.; Chesla, D. W.; Teixeira, J. M.; Adams, M.; Drapkin, R.; Esquibel, C.; Sheridan, R. T. C.; Wang, T.; Sandberg, R.; Triche, T. J.; Shen, H.
10.1101/2022.03.14.484332 — molecular biology — Posted on 2025-05-20
1844 Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature
Unitt, A.; Krisna, M. A.; Parfitt, K. M.; Jolley, K. A.; Maiden, M. C. J.; Harrison, O. B.
10.1101/2025.03.28.646058 — genomics — Posted on 2025-05-20
1848 A mechanism linking dopamine's roles in reinforcement, movement and motivation
Hamilos, A. E.; Wijsman, I. C.; Ding, Q.; Assawaphadungsit, P.; Ozcan, Z.; Norri, E.; Assad, J. A.
10.1101/2025.04.04.647288 — neuroscience — Posted on 2025-05-20
1852 TNF-mediated myeloid-instructed CD14+CD4+ T cells within the tumor microenvironment are associated with poor survival in non-small cell lung cancer.
Marceaux, C.; Tarasova, I.; Batey, D.; Yokote, K.; Gayevskiy, V.; Jain, R.; Leiwe, M.; Choux, L.; Riley, L.; Tubau, N.; Hywood, J.; Christie, M.; Antippa, P.; Speed, T. P.; Rogers, K. L.; Phipson, B.; Asselin-Labat, M.-L.
10.1101/2024.08.02.606259 — cancer biology — Posted on 2025-05-20
1855 Magnetic Resonance Imaging for Improved Brain Tumor Detection
Benyard, B. A.; Soni, N.; Swain, A.; Srivastava, N.; Khokhar, S.; Yehya, N.; Fan, Y.; Kumar, D.; Nanga, R. P. R.; Frenneaux, M. P.; Haris, M.; Reddy, R.
10.1101/2025.05.06.652446 — bioengineering — Posted on 2025-05-20
1856 Dissecting bioelectrical networks in photosynthetic membranes with electrochemistry
Lawrence, J. M.; Egan, R. M.; Wey, L. T.; Bali, K.; Chen, X.; Kosmützky, D.; Eyres, M.; Nan, L.; Wood, M. H.; Nowaczyk, M. M.; Howe, C. J.; Zhang, J. Z.
10.1101/2025.03.18.643929 — biochemistry — Posted on 2025-05-20
1857 A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation
Nguyen, V. C. B.; Özden, C.; Dong, K.; Koc, O.; Torres-Ocampo, A. P.; Dziedzic, N.; Flaherty, D.; Huang, J.; Sankura, S.; Abromson, N. L.; Tomchick, D. R.; Fissore, R. A.; Chen, J.; Garman, S. C.; Stratton, M.
10.1101/2024.03.24.586494 — biochemistry — Posted on 2025-05-20
1859 Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages
Khan, I.; MacDonald, S. J.; Markusson, S.; Kies, P. J.; Kraemer-Zimpel, C.; Robson, C.; Parker, J. L.; Newstead, S.; Boucher, D.; Hammer, N. D.; Van der Woude, M.; Thomas, G. H.
10.1101/2024.12.02.626324 — microbiology — Posted on 2025-05-20
1860 Investigating Factors Driving Shifts in Subtype Dominance within H5Nx Clade 2.3.4.4b High-Pathogenicity Avian Influenza viruses
Billington, E.; Di Genova, C.; Warren, C. J.; Thomas, S. S.; Johnson, S.; Riccio, S.; De Sliva, D.; Peers-Dent, J.; Temperton, N. J.; da Costa, K.; Byrne, A. M. P.; Airey, M.; Schlachter, A.-L.; Yang, J.; Nunez, A.; Iqbal, M.; Slomka, M. J.; Brown, I. H.; Banyard, A. C.; James, J.
10.1101/2025.04.23.650244 — microbiology — Posted on 2025-05-20
1861 Sex-dependent neural plasticity in response to damage
Recatala-Martinez, M.; Bosch, M.; Gaspar, P.; Mineo, A.; Rios, S.; Miguel-Aliaga, I.; Morey, M.
10.1101/2025.05.05.652027 — neuroscience — Posted on 2025-05-20
1864 Beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual postural task
Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Szul, M. J.; Bonaiuto, J. J.; Bonnefond, M.; Schmitz, C.
10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-05-20
1866 Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.
CHIE, J. A. K. H. C.; PERSOHN, S. A.; PANDEY, R. S.; SIMCOX, O. R.; SALAMA, P.; TERRITO, P. R.
10.1101/2025.05.12.653558 — neuroscience — Posted on 2025-05-20
1867 miRNA synergism impaired metabolic programming of oral cancer cells by selectively enhancing target gene specificity
Mazumder, S.; Banerjee, U.; Sinsinwar, S.; Mandal, S.; Prusty, D.; Babele, P.; Das, B.; Manna, S. K.; Ray, J. G.; Chatterjee, R.
10.1101/2024.08.01.606174 — cancer biology — Posted on 2025-05-20
1869 Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis
Nissen, I.; Dakhel, S.; Chakraborty, C.; Nygaard, A. H.; Kirkeby, A.; Hornblad, A.; Erdem, C.; Remeseiro, S.
10.1101/2025.04.30.651564 — genomics — Posted on 2025-05-20
1870 Mast fruiting in a large tropical African legume tree provides evidence for the nutrient resource limitation hypothesis
Newbery, D. M.; Schwan, S.; Chuyong, G. B.; Neba, G. A.; Etta, C. E.; Norghauer, J. M.; Worbes, M.
10.1101/2023.04.03.535348 — ecology — Posted on 2025-05-20
1871 Temperature changes are signaled in cyanobacteria through the PipX interaction network
Llop, A.; Bibak, S.; Mata-Balaguer, T.; Tremino, L.; Fuertes-Garcia, L.; Neira, J. L.; Dixon, R.; Contreras, A.
10.1101/2025.05.19.654826 — molecular biology — Posted on 2025-05-20
1873 An artefact-resilient wide bandwidth bidirectional graphene neural interface
Prokop, M.; Esparza-Iaizzo, M.; Masvidal-Codina, E.; Codadu, N. K.; Rathore, D.; Ria, N.; Kostarelos, K.; del Corro, E.; Garcia-Cortadella, R.; Wykes, R. C.; Guimera-Brunet, A.; Garrido, J. A.
10.1101/2025.05.15.653988 — neuroscience — Posted on 2025-05-20
1878 Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy
Tang, E.; Hu, Y.; Cao, G.; Asby, N. W.; Nguyen, D.-T.; Aboelella, N. S.; Ruiz, H.; Zhao, Y.; Xie, L.; Chen, X.; Bishop, M. R.; Riedell, P. A.; LaBelle, J. L.; Kline, J. P.; Huang, J.
10.1101/2025.05.13.653878 — immunology — Posted on 2025-05-20
1879 Integration of past caspase activity biases cell elimination in vivo
Cumming, T.; Villars, A.; Davidovic, A.; Levillayer, F.; Valon, L.; Levayer, R.
10.1101/2025.05.18.654727 — developmental biology — Posted on 2025-05-20
1880 Pathogenicity of Commensal Gut Biofilm In Prefrail Aging
Le Cosquer, G.; Pannier, M.; Meunier, E. S.; Thevenin, J.; Pyhourquet, E.; Guyonnet, S.; Vellas, B.; Santin, Y.; Guiard, B.; Parini, A.; Buscail, L.; Bournet, B.; Guillemet, D.; Deraison, C.; Vergnolle, N.; Motta, J. P.
10.1101/2024.06.04.596782 — microbiology — Posted on 2025-05-20
1881 Two Axes of White Matter Development
Luo, A. C.; Meisler, S. L.; Sydnor, V. J.; Alexander-Bloch, A.; Bagautdinova, J.; Barch, D. M.; Bassett, D. S.; Davatzikos, C.; Franco, A. R.; Goldsmith, J.; Gur, R. E.; Gur, R. C.; Hu, F.; Jaskir, M.; Kiar, G.; Keller, A. S.; Larsen, B.; Mackey, A. P.; Milham, M. P.; Roalf, D. R.; Shafiei, G.; Shinohara, R. T.; Somerville, L. H.; Weinstein, S. M.; Yeatman, J. D.; Cieslak, M.; Rokem, A.; Satterthwaite, T. D.
10.1101/2025.03.19.644049 — neuroscience — Posted on 2025-05-20
1884 Evolutionary dynamics of gene and isoform regulation underlying rapid and parallel adaptive radiations
Singh, P.; Ahi, E. P.; Duenser, A.; Durdevic, M.; Gessl, W.; Schaeffer, S.; Seehausen, O.; Sturmbauer, C.
10.1101/2025.05.13.653813 — evolutionary biology — Posted on 2025-05-20
1886 Network-based Near-Scalp Personalized Brain Stimulation Targets
Kong, R.; Xue, A.; Ooi, L. Q. R.; Asplund, C.; Tan, X. W.; Goh, S. E.; Lee, J. J.; Koh, J. Z. J.; Tan, R. S. Y.; Singh, H. K. G.; Tan, T. W. K.; Webler, R. D.; Fox, M. D.; Siddiqi, S. H.; Tor, P.-C.; Yeo, B. T. T.
10.1101/2025.05.15.654391 — neuroscience — Posted on 2025-05-20
1887 The anti-cancer drug trametinib suppresses angiotensin-induced cardiac remodelling in mice but is detrimental to function
Cooper, S. T.; Duvenage, E.; Gattari, D.; Cull, J. J.; Dash, P. R.; Chan, D.; Soria, M. L.; Rossi, M.; Nasuto, S. J.; Holderbaum, W.; Kelion, A.; Sugden, P. H.; Glennon, P. E.; Clerk, A.
10.1101/2025.05.16.654397 — physiology — Posted on 2025-05-20
1888 Interpreting biochemical text with language models:a machine learning framework for reaction extraction and cheminformatic validation
Lim, D.; Badrinarayanan, S.; Sterling, K. C.; Rajesh, G.; Mistry, E.; Yang, D.; Lee, M.; Hsu, K. B.; Manjrekar, M.; Areff, C.; Xie, P.; Kristanto, I. A.; Chandran, A.; Anderson, J. C.
10.1101/2025.05.15.654376 — bioinformatics — Posted on 2025-05-20
1891 Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findings
Mahdy, A. K. H.; ElAbd, H.; Kokubun, E. E.; Kriukova, V.; Pesesky, M.; May, D. H.; Olbjorn, C.; Perminow, G.; Bengtson, M.-B.; Ricanek, P.; Andersen, S.; Detlie, T. E.; Kristensen, V. A.; Moum, B.; Vatn, M.; Bokemeyer, B.; Hov, J.; Halfvarsson, J.; Schreiber, S.; the IBSEN and IBSEN-III study group, ; Howie, B.; Robins, H. S.; Hoivik, M. L.; Franke, A.
10.1101/2025.05.16.654339 — immunology — Posted on 2025-05-20
1893 Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body
Sun, Z.; Lih, T. M.; Hoang, T.; Chen, S.-Y.; Xu, J.; Lin, D. C.; Wang, Y.; Woo, J.; Huang, Y.; Chen, L.; Liu, H.; Alpern, M.; Milosevic, J.; He, H.-Z.; Chaerkady, R.; Wang, Q.; Zhang, H.
10.1101/2025.05.15.654311 — systems biology — Posted on 2025-05-20
1895 Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation
Kwon, Y. Y.; Liang, Y.; Gomez-Jenkins, M.; Ahmed, M.; Jiang, G.; Hsiang, J.; Lewis, D.; Janowitz, T.; Goncalves, M. D.; White, E.; Hui, S.
10.1101/2025.05.15.654370 — cancer biology — Posted on 2025-05-20
1896 Machine Learning-Driven Drug Repurposing for KRAS G12C and KRAS G12D Inhibition
Fuschi, G.; Germain, J. S.; Bebensee, D.; Moawad, C.; Aladysheva, A.; Mohamed, A.; Elwakeel, E.; Brooks, B. R.; Amin, M.
10.1101/2025.05.16.654410 — cancer biology — Posted on 2025-05-20
1897 Benchmarking Spectral Library and Database Search Approaches for Metaproteomics Using a Ground-Truth Microbiome Dataset
Rajczewski, A. T.; Mehta, S.; Wagner, R.; Gabriel, W.; Johnson, J.; Do, K.; Vintila, S.; Wilhelm, M.; Kleiner, M.; Searle, B. C.; Griffin, T.; Jagtap, P.
10.1101/2025.05.15.654320 — bioinformatics — Posted on 2025-05-20
1898 Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs
Soldatkina, O.; Ventura-San Pedro, L.; El Hommad, A.; Ramirez, J. M.; Ripoll-Cladellas, A.; Sopena-Rios, M.; Ordi, J.; Pujol-Gualdo, N.; Mele, M.
10.1101/2025.05.16.654406 — genomics — Posted on 2025-05-20
1900 CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for embryonic cortical neural stem cell maintenance
Zheng, J.; Qi, S.; Wu, H.; Wu, J.; Chen, G.; Wang, H. J.; Pan, H.; Li, J.; Cheng, C.; Tang, K.; Lau, L. F.; Shen, Q.
10.1101/2025.05.16.654402 — developmental biology — Posted on 2025-05-20
1902 Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human Studies
Rivas-Torrubia, M.; Morell, M.; Makowska, Z.; Kageyama, J.; Bosshard, A.; Lindblom, J.; Borghi, M. O.; Bettacchioli, E.; PRECISESADS flow cytometry consortium, ; PRECISESADS clinical consortium, ; Parodis, I.; Beretta, L.; Maranon, C.; Pers, J.-O.; Lesche, R.; McDonald, F.; Alarcon-Riquelme, M. E.; Barturen, G.
10.1101/2025.05.15.654304 — immunology — Posted on 2025-05-20
1903 Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury.
Kim, H. G.; Gauthier, M.-P. L.; Higgs, A.; Hernandez, D. A.; Zhou, M.; Brant, J. O.; Bacher, R. L.; Darden, D. B.; Wallet, S. M.; Mathews, C. E.; efron, P. A.; Kladde, M. P.; Maile, R.
10.1101/2025.05.15.654340 — immunology — Posted on 2025-05-20
1904 Early initiation of small intestine neuroendocrine tumors
Schiller, A.; Hultmark, A.; Lindberg, M.; Socratous, A.; Luijts, T.; Van den Eynden, J.; Elf, A.-K.; Rossi Norrlund, R.; Arvidsson, Y.; Elias, E.; Larsson, E.
10.1101/2025.05.16.654489 — cancer biology — Posted on 2025-05-20
1905 Medical Images as Biomarkers of Ageing - From Global and Local Patterns to Digital Twins
Mueller, T. T.; Starck, S.; Llalloshi, R.; Kaissis, G.; Ziller, A.; Rueckert, D.; Braren, R.
10.1101/2025.05.18.654705 — bioinformatics — Posted on 2025-05-20
1906 A high-quality draft genome assembly of the Neotropical butterfly, Batesia hypochlora (Nymphalidae: Biblidinae)
Pham, T. N.; Duplouy, A.; See, J.; Knowles, L. S.; Marquina, E.; Gallice, G. R.; Molleman, F.; Oostra, V.
10.1101/2025.05.17.654659 — genomics — Posted on 2025-05-20
1910 Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model
Sun, G.; Lin, W.; Chen, R.; Jiang, L.; DeMott, M.; McShane, A.; Chan, M. C. K.; Ehrbar, D.; Zhang, X.; Begley, T.; Emili, A.; Wolozin, B.; Dedon, P.
10.1101/2025.05.15.654371 — neuroscience — Posted on 2025-05-20
1912 An autonomous AI agent for universal behavior analysis
Aljovic, A.; Lin, Z.; Wang, W.; Zhang, X.; Marin-Llobet, A.; Liang, N.; Canales, B.; Lee, J.; Baek, J.; Liu, R.; Li, C.; Li, N.; Liu, J.
10.1101/2025.05.15.653585 — neuroscience — Posted on 2025-05-20
1913 eIF4G2-Mediated Translation Initiation of Histone Modifiers Is Essential for Intestinal Stem Cell Maintenance and Differentiation
Kunitomi, H.; Khaine, A. M.; Jamee, R.; Lancero, M.; Raychaudhuri, A.; Perli, S. D.; Sato, Y.; Iwasaki, M.; Ruivo, P. R.; Tomoda, K.; Mito, M.; Shichino, Y.; Iwasaki, S.; Yamanaka, S.
10.1101/2025.05.19.652834 — cell biology — Posted on 2025-05-20
1915 Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality
Schwaba, T.; Clapp Sullivan, M. L.; Akingbuwa, W. A.; Ilves, K.; Tanksley, P. T.; Williams, C. M.; Dragostinov, Y.; Liao, W.; Ackerman, L. S.; Fealy, J. C. M.; Hemani, G.; de la Fuente, J.; Gupta, P.; Stein, M. B.; Gelernter, J.; Levey, D. F.; Vosa, U.; Ausmees, L.; Realo, A.; Estonian Biobank Research Team, ; Vaht, M.; Allik, J.; Esko, T.; Mottus, R.; Vainik, U.; Jonsdottir, G. A.; Thorleifsson, G.; Gunnarsson, A. F.; Bjornsdottir, G.; Thorgeirsson, T. E.; Steffansson, H.; Stefansson, K.; Cheesman, R.; Qin, Q.; Corfield, E. C.; Ask, H.; Ask Torvik, F.; Ystrom, E.; Tesli, M.; Boomsma, D. I.;
10.1101/2025.05.16.648988 — genomics — Posted on 2025-05-20
1916 Low-coverage whole-genome sequencing facilitates accurate and cost-effective haplotype reconstruction in complex mouse crosses
Widmayer, S. J.; Wooldridge, L. K.; Swanzey, E.; Barter, M.; Snow, C.; Saul, M. C.; Meng, Q.; Dumont, B. L.; Reinholdt, L. G.; Gatti, D. M.
10.1101/2025.05.19.654056 — genetics — Posted on 2025-05-19
1919 Spatiotemporal Models Reveal Dynamic Growth Patterns in U.S. West Coast Groundfish
Odell, A. N.; Marshall, K. N.; Ward, E. J.; Johnson, K. F.; Baskett, M. L.
10.1101/2025.05.19.653526 — ecology — Posted on 2025-05-19
1922 Understudied and underprotected: biodiversity and conservation challenges in the Konkan region of Maharashtra
Chhaya, K.; Nulkar, G.; Bapat, P.; Barve, H.; Bhave, N.; Bokkasa, A.; Dandekar, V.; Desai, S.; Ghate, K.; Gindi, R.; Joglekar, A.; Joshi, A.; Joshi, P.; Kamat, S.; Karandikar, M.; Khod, C.; Kulkarni, M.; Lad, H.; Mandavkar, A.; Mestry, P.; Mishrikotkar, Y.; More, P.; Nerurkar, S.; Niphadkar, M.; Patwardhan, A.; Pawar, P.; Punjabi, G.; Purohit, P.; Rajwade, M.; Rane, M.; Raorane, V.; Surve, N.; Thakur, S.; Watve, A.; Naniwadekar, R.
10.1101/2025.05.16.653652 — ecology — Posted on 2025-05-20
1924 Mutational landscape and molecular bases of echinocandin resistance
Durand, R.; Torbey, A. G.; Giguere, M.; Pageau, A.; Dube, A. K.; Lagüe, P.; Landry, C. R.
10.1101/2024.07.21.604487 — molecular biology — Posted on 2025-05-19
1927 The superior colliculus arbitrates whole-brain dynamics for unconscious visual insight
Murata, T.; Kunishige, K.; Seno, S.; Ohzawa, I.; Kaneko, K.; Yanagida, T.; Haruno, M.; Hosoda, K.
10.1101/2025.04.09.648050 — neuroscience — Posted on 2025-05-19
1929 MAGELLAN: Automated Generation of Interpretable Computational Models for Biological Reasoning
Clarke, M. A.; Barker, C. G.; Sun, Y.; Roumeliotis, T. I.; Choudhary, J. S.; Fisher, J.
10.1101/2025.05.16.653408 — systems biology — Posted on 2025-05-19
1930 Accelerating Natural Product Discovery with Linked MS-Genomics and Language/Transformer-Based Models
Tay, D. W. P.; Koh, W.; Ang, S. J.; Wong, Z. M.; Lim, Y. W.; Heng, E.; Yeo, N. Z. X.; Adaikkappan, K.; Wong, F. T.; Lim, Y. H.
10.1101/2025.01.20.633932 — synthetic biology — Posted on 2025-05-19
1931 Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.
Kelty, T. J.; Franczak, E.; Gay, N. R.; Many, G. M.; Sagendorf, T. J.; Sanford, J. A.; Hou, Z.; Gaul, D. A.; Fernandez, F.; Burant, C.; Hevener, A. L.; Adkins, J. N.; Bodine, S.; Lindholm, M. E.; Ortlund, E. A.; Schenk, S.; Thyfault, J. P.; Rector, R. S.; MoTrPAC Research Group,
10.1101/2025.05.16.652859 — physiology — Posted on 2025-05-19
1932 E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression
Valdivieso-Rivera, F.; Furino, V. O.; Leher, C. E.; Zanesco, A. M.; Cruz, M. K.; Gan, F. C.; Santoro, A. L.; Regina-Ferreira, L.; Santos, G. L.; Goncalves, T. T.; Leiria, L. O.; Moraes-Vieira, P. M.; Castilho, R. F.; Mori, M. A.; Velloso, L. A.; Sponton, C. H.
10.1101/2025.05.19.652826 — physiology — Posted on 2025-05-19
1933 AMPK activation prevents HCC development through inhibition of HNF4a activity
Sun, Z.; Linares, B.; Urdiales, C.; Alsarmi, F.; Putluri, N.; Van Nostrand, J. L.
10.1101/2025.05.16.652569 — cancer biology — Posted on 2025-05-19
1934 A Generalizable Tension Sensor Platform for Mechanotherapeutic Discovery
Pawlak, M. R.; Baldys, A.; McMahon, M. C.; Cichocki, F.; Gordon, W. R.
10.1101/2025.05.15.653325 — biophysics — Posted on 2025-05-19
1935 BroodScan: A Honeybee Brood Scanner Technology
Stefanec, M.; Hofstadler, D. N.; Kaercher, M. H.; Schmickl, T.
10.1101/2025.05.17.651227 — animal behavior and cognition — Posted on 2025-05-19
1937 Classification of Urticaceae based on morphology and phylogenetic inference
Monro, A. K.; Maurin, O.; Fu, L.-F.; Wells, T.; Wilmot-Dear, M.; Beentje, J.; Hind, N.; Friis, I.; Brewer, G.; Cowan, R.; Dodsworth, S.; Dong, J.; Epitawalage, N.; Sabino Kikuchi, I.; Larridon, I.; Moore, A.; Sauquet, H.; Ujetz, J.; Wei, Y.-G.; Wu, Z.-Y.; Forest, F.; Baker, W. J.; Gardner, E. M.
10.1101/2025.05.16.651835 — evolutionary biology — Posted on 2025-05-19
1940 Evidence-based guidelines for improving network detectability in rodent fMRI
Urosevic, M.; Desrosiers-Gregoire, G.; Fouquet, J. P.; Devenyi, G. A.; Gallino, D.; Yee, Y.; Chakravarty, M.
10.1101/2025.05.19.653309 — neuroscience — Posted on 2025-05-19
1943 Multiscale analysis of myelin alterations in skin biopsies from synucleinopathies.
Di Fabrizio, M.; van der Gaag, B. L.; Terzi, M.; Aaron, E.; Steerenberg, N. B.; Bol, J. G.; van de Berg, W. D. J.; Stahlberg, H.; Lewis, A. J.
10.1101/2025.05.15.654285 — neuroscience — Posted on 2025-05-19
1946 Speed breeding transgenic American chestnut trees toward restoration
Klak, T.; Pilkey, H.; May, V. G.; Matthews, D.; Oakes, A. D.; Tan, E. H.; Newhouse, A. E.
10.1101/2025.05.19.654928 — plant biology — Posted on 2025-05-19
1947 STT3A is required for recognition of pathogen-derived sphingolipids in Arabidopsis
Choi, S.; Shimizu, M.; Abe, A.; Ishihama, N.; Ishikawa, Y.; Takemoto, D.; Shirasu, K.; Takano, Y.; Terauchi, R.; Kato, H.
10.1101/2025.05.18.654772 — plant biology — Posted on 2025-05-19
1948 Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen
Widjaja, V.; D'Orazio, S. M.; Das, P.; Takeda, X.; Rajendran, D. T.; Shi, Y.; Varghese, I.; Lam, Y.; Wang, J.; Batista, V. S.; Bhandari, V.; Lisi, G. P.
10.1101/2025.05.15.654344 — biophysics — Posted on 2025-05-19
1949 Multiscale Segmentation using Hierarchical Phase-contrast Tomography and Deep Learning
Zhou, Y.; Aslani, S.; Javanmardi, Y.; Brunet, J.; Standsby, D.; Carroll, S.; Bellier, A.; Ackermann, M.; Tafforeau, P.; Lee, P. D.; Walsh, C. L.
10.1101/2025.05.15.654263 — bioinformatics — Posted on 2025-05-19
1951 Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen
McCool, R. S.; Acreman, C. M.; Powell, A. E.; Picucci, S. I.; Stieh, D. J.; Huynh, J.; Caruso, H.; Park, S.; O'Rear, J.; Chen, J.-L.; Palanski, B. A.; Byrne, P. O.; Sponholtz, M. R.; Chou, C.-W.; Kim, J.; Ledgerwood, J. E.; Weidenbacher, P. A.- B.; McLellan, J. S.
10.1101/2025.05.19.654955 — biochemistry — Posted on 2025-05-19
1953 Grass Rhizome Proteomics Reveals Convergent Freezing-Tolerance Strategies
Oren, E.; Zhai, J.; Rooney, T. E.; Angelovici, R.; Hale, C. O.; Brindisi, L. J.; Hsu, S.-K.; Gault, C. M.; Hua, J.; La, T.; Lepak, N.; Fu, Q.; Buckler, E. S.; Romay, M. C.
10.1101/2025.05.15.654294 — evolutionary biology — Posted on 2025-05-19
1954 A domestication change at PvMYB26 in common bean sheds light on the origins of Middle American agriculture
Celebioglu, B.; Roy, J.; Farmer, A.; English, S.; Yu, X.; Xu, X.; McClean, P. E.; Gepts, P.; Parker, T.
10.1101/2025.05.15.654381 — evolutionary biology — Posted on 2025-05-19
1956 Annotating opportunistic camera-trap images with conditions ofrecording, for the disease surveillance of Eurasian lynx (Lynxlynx)
Blin, L.; Decors, A.; Chenesseau, D.; Lenglin, L.; Ryser-Degiorgis, M.-P.; Zimmermann, F.; Borel, S.; Bastian, S.
10.1101/2025.05.15.654015 — ecology — Posted on 2025-05-19
1959 Candida auris Metabolism and Growth Preferences in Physiologically Relevant Skin-like Conditions
Nicklas, J. P.; Deming, C.; Lee-Lin, S.-Q.; Conlan, S.; Shen, Z.; Blaustein, R.; Segre, J. A.
10.1101/2025.05.18.654780 — microbiology — Posted on 2025-05-19
1960 Divergent MIC of Clarithromycin and Azithromycin Against Clinical Isolates of Mycobacterium abscessus Complex
Xu, P.; Cao, D.; Xiang, Y.; Dong, X.; Jiang, X.; Ji, Z.; Li, Y.; Yuan, X.; Qiu, Y.; Bi, K.; Zhang, Y.; Han, Y.; Xu, K.; Zhang, Y.
10.1101/2025.05.19.654969 — microbiology — Posted on 2025-05-19
1962 The Cell Wall Controls Stem Cell Fate in the Arabidopsis Shoot Apical Meristem
Zerin, T.; Ruiz-Duarte, P.; Schuerholz, A.-K.; Prevedel, R.; Bevilacqua, C.; Ma, Y.; Schlamp, T.; Wenzl, C.; El Arbi, N.; Miotk, A.; Greb, T.; Lohmann, J. U.; Wolf, S.
10.1101/2025.05.19.654883 — plant biology — Posted on 2025-05-19
1963 Physiological characterization in a somaclonal mutant for fruit shape derived from persimmon 'Hiratanenashi'
Horiuchi, A.; Matsuzaki, R.; Onoue, N.; Ushijima, K.; Kubo, Y.; Akagi, T.; Minamikawa, M. F.
10.1101/2025.05.19.654774 — plant biology — Posted on 2025-05-19
1967 Fast, flexible gene cluster family delineation with IGUA
Larralde, M.; Blom, J.; Gourle, H.; Carroll, L. M.; Zeller, G. M.
10.1101/2025.05.15.654203 — bioinformatics — Posted on 2025-05-19
1968 Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPs
Pan, Y.; Zhong, Y.; Chen, H.; Zhang, Y.; Dai, Z.; Chen, J.; Tan, K.; Chen, X.; Qiu, D.; Sheng, L.; Tan, X.; Fan, Y.; Bu, Y.; Zhou, Z.; Yang, Z.; Duan, R.; Guan, M.; Gao, G.; Li, H.
10.1101/2025.05.19.654800 — bioengineering — Posted on 2025-05-19
1970 Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice
Castillo, L. F.; Heyden, K. E.; Williamson, A. R.; Ma, W.; Malysheva, O. V.; Vacanti, N. M.; Thalacker-Mercer, A. E.; Field, M. S.
10.1101/2025.05.19.654973 — biochemistry — Posted on 2025-05-19
1975 The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid
Kleinpeter, A. B.; Mallery, D. L.; Anna, A.; Burdick, R. C.; Renner, N.; Klarhof, J. O.; Vamos, B.; Pathak, V. K.; James, L. C.; Freed, E. O.
10.1101/2025.05.19.654868 — microbiology — Posted on 2025-05-19
1977 The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in ApcMin/+ mice
Hamidi Nia, L.; Alqudah, S.; Markley, R. L.; DeLucia, B.; Bobba, V.; Elmallah, J.; Nemet, I.; Sangwan, N.; Claesen, J.
10.1101/2025.05.18.654755 — microbiology — Posted on 2025-05-19
1978 Evasion of CARD8 Activation During HIV-1 Assembly
Hughes, I. K.; Hood, J. B.; Quinones-Molina, A.; Akiyama, H.; Gummuluru, S.
10.1101/2025.05.19.654850 — microbiology — Posted on 2025-05-19
1986 The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
Tharp, M. E.; Han, C. Z.; Talukdar, M.; Balak, C. D.; Fitzpatrick, C.; O'Connor, C.; Preissl, S.; Buchanan, J.; Nott, A.; Escoubet, L.; Mavrommatis, K.; Gupta, M.; Schwartz, M. S.; U, H. S.; Jones, P. S.; Levy, M. L.; Gonda, D. D.; Ben-Haim, S.; Ciacci, J.; Barba, D.; Khalessi, A.; Coufal, N. G.; Chen, C. C.; Glass, C. K.; Page, D. C.
10.1101/2024.06.06.597433 — genomics — Posted on 2025-05-19
1989 Non-redundant cardiolipin synthases shape membrane composition and support stress resilience in Bacteroides fragilis
Schnizlein, M. K.; Hong, B.; Nguyen, J. N. T.; Jones, K.; Rodriguez, A. I.; Fiebig, A.; Campagna, S. R.; Balunas, M. J.; O'Halloran, T. V.; Crosson, S.
10.1101/2025.05.12.653583 — microbiology — Posted on 2025-05-19
1991 Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D
Chowdhury, B.; Zhu, K.; Li, C.; Luebeck, J.; Chapman, O. S.; Kraft, K.; Zhang, S.; Chavez, L.; Henssen, A. G.; Mischel, P. S.; Chang, H.; Bafna, V.
10.1101/2025.02.01.636064 — cancer biology — Posted on 2025-05-19
1992 Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection
Mukherjee, R.; Bhattacharya, A.; Tomaskovic, I.; Mello-Vieira, J.; Brunstein, M. E.; Basoglu, M.; Veenendaal, T.; Bailey, H.; Colby, T.; Misra, M.; Eimer, S.; Klumperman, J.; Munch, C.; Matic, I.; Dikic, I.
10.1101/2025.05.19.654886 — cell biology — Posted on 2025-05-19
1993 ASPPs multimerize protein phosphatase 1
Wei, D. T.; Morrison, K. N.; Beacham, G. M.; Beyrent, E.; Zhang, Y.; Florens, L.; Hollopeter, G.
10.1101/2025.05.16.654433 — cell biology — Posted on 2025-05-19
1994 Dynamic hyperplastic cardiac growth in Burmese pythons
Tan, Y.; Martin, T. G.; Peter, A.; Ozeroff, C. D.; Ebmeier, C. C.; Doptis, R.; Harrison, B.; Leinwand, L.
10.1101/2025.05.19.654898 — cell biology — Posted on 2025-05-19
1995 Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach
Schoenfeld, J.; Liebisch, N.; Brunst, S.; Weizel, L.; Knapp, S.; Kannt, A.; Proschak, E.; Hiesinger, K.
10.1101/2025.05.19.654949 — cell biology — Posted on 2025-05-19
1998 When is microbial cross-feeding evolutionarily stable?
Lopez, J. A.; Liu, B.; Li, Z.; Donia, M. S.; Wingreen, N. S.
10.1101/2025.05.16.654511 — microbiology — Posted on 2025-05-19
1999 UTX Coordinates TCF1 and STAT3 to Control Progenitor CD8+ T cell Fate in Autoimmune Diabetes
Chen, H.-C.; Wang, H. H.; Shpargel, K. B.; Kohn, L. A.; Sailer, D.; Zhang, S.; McCarthy, E. C.; Seyedsadr, M.; Zhou, Z.; Yin, X.; Wilkinson, N. M.; Peluso, E.; Bustillos, C.; Ortega, J.; Yang, L.; Buzzelli, A. A.; Whitmire, J. K.; Lechner, M. G.; Hugo, W.; Su, M. A.
10.1101/2024.12.12.628206 — immunology — Posted on 2025-05-19
2000 Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum
Stanley, A. T.; Choi, S. J.; Frank, A.; Makowicz, E.; Cataldi, S.; Shashaank, N.; Mosharov, E. V.; Lacefield, C.; Miniaci, M.; Sulzer, D.
10.1101/2025.04.29.651089 — neuroscience — Posted on 2025-05-19
2001 Beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual postural task
Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Szul, M. J.; Bonaiuto, J. J.; Bonnefond, M.; Schmitz, C.
10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-05-19
2002 CABaNe, an automated, high content ImageJ macro for cell and neurite analysis
Thibieroz, N.; Cordelieres, F.; Machillot, P.; Marchadier, L.; Singh, A.; Picart, C.; Migliorini, E.
10.1101/2025.03.07.641590 — neuroscience — Posted on 2025-05-19
2006 Amyloid-beta deposition and reduced drainage at the cribriform plate lymphatics in APP/PS1 mouse model of Alzheimer's Disease
Vrba, S. M.; Laaker, C. J.; Limkar, A. R.; Hsu, M.; Ricke, W. A.; Ulland, T. K.; Pehar, M.; Sandor, M.; Fabry, Z.
10.1101/2025.05.15.654007 — neuroscience — Posted on 2025-05-19
2008 TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes
Rudzitis, C. N.; Lakk, M.; Singh, A.; Redmon, S. N.; Kirdajova, D.; Tseng, Y.-T.; deIeso, M. L.; Stamer, D.; Herberg, S.; Krizaj, D.
10.1101/2024.11.05.622187 — physiology — Posted on 2025-05-19
2010 Structural basis for Porcupine inhibition
Black, K. A.; Mobbs, J. I.; Venugopal, H.; Dite, T. A.; Leis, A.; Wong, L. L.; Dagley, L.; Thal, D. M.; Glukhova, A.
10.1101/2025.05.19.654776 — biochemistry — Posted on 2025-05-19
2011 A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5
Yamashita, T.; Asamoto, K.; Fujii, K.; Fujiyabu, C.; Ohuchi, H.; Shichida, Y.
10.1101/2025.05.19.654871 — biochemistry — Posted on 2025-05-19
2012 Molecular determinants of extracellular TIMP-3 accumulation in Sorsby fundus dystrophy.
Betts, J. H.; Hampton, K.; Strickland, D. K.; Clark, S. J.; Day, A. J.; Troeberg, L.
10.1101/2025.05.19.654781 — biochemistry — Posted on 2025-05-19
2013 Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells
Nemkov, T.; Stauffer, E.; Cendali, F.; Stephenson, D.; Nader, E.; Robert, M.; Skinner, S.; Dzieciatkowska, M.; Hansen, K. C.; Robach, P.; Millet, G. Y.; Connes, P.; D'Alessandro, A.
10.1101/2025.04.09.648006 — biochemistry — Posted on 2025-05-19
2014 Backbone Assignment of a 28.5 kDa Class A Extended Spectrum β-Lactamase by High-Field, Carbon-Detected Solid-State NMR
Williams, C. G.; Wang, S.; Thome, A. F.; Warmuth, O. A.; Sakhrani, V.; Rienstra, C. M.; Mueller, L. J.
10.1101/2025.05.18.654753 — biochemistry — Posted on 2025-05-19
2021 SIRT1 limits neuronal fate following DNA damage
Kroll, C.; Karacora, B.; Meuth, S.; Fritz, G.; Aktas, O.; Berndt, C.; Prozorovski, T.
10.1101/2025.05.19.654885 — cell biology — Posted on 2025-05-19
2022 The Molecular Logic of Gtr1/2 and Pib2 Dependent TORC1 Regulation in Budding Yeast
Cecil, J. H.; Padilla, C. M.; Lipinski, A. A.; Langlais, P.; Luo, X.; Capaldi, A. P.
10.1101/2023.12.06.570342 — molecular biology — Posted on 2025-05-19
2023 Do Existing COVID-19 Vaccines Need to Be Updated in 2025?
Mellis, I. A.; Wu, M.; Wang, Q.; Bowen, A.; Gherasim, C.; Pierce, V. M.; Shah, J. G.; Purpura, L. J.; Yin, M. T.; Gordon, A.; Guo, Y.; Ho, D. D.
10.1101/2025.05.02.651777 — microbiology — Posted on 2025-05-19
2025 Thrifty wide-context models of B cell receptor somatic hypermutation
Sung, K.; Johnson, M. M.; Dumm, W.; Simon, N.; Haddox, H.; Fukuyama, J.; Matsen, F. A.
10.1101/2024.11.26.625407 — immunology — Posted on 2025-05-19
2029 Whole-brain chemosensory responses of both C. elegans sexes
Seyedolmohadesin, M.; Fu, X.; Torkashvand, M.; Rasouli, S.; Lang, S.; Li, L.; Kalinski, C.; Cook, S. J.; Schroeder, F. C.; Yemini, E.; Venkatachalam, V.
10.1101/2025.05.15.654129 — neuroscience — Posted on 2025-05-19
2031 Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
Frank, S.; Persse, T.; Coleman, I. M.; Bankhead, A.; Li, D.; DeSarkar, N.; Wilson, D.; Rudoy, D.; Vashisth, M.; Galipeau, P.; Yang, M.; Hanratty, B.; Dumpit, R.; Morrissey, c.; Corey, E.; Montgomery, R.; Haffner, M.; Pritchard, C.; Vasioukhin, V.; Ha, G.; Nelson, P. S.
10.1101/2024.07.16.603734 — cancer biology — Posted on 2025-05-19
2033 In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis
Haney, M. S.; Shankar, A.; Olender, L.; Hsu, I.; Miyauchi, M.; Palovics, R.; Meaker, G. A.; Kaito, S.; Rizq, O.; Khoo, H. M.; Bozhilov, Y.; Igarashi, K. J.; Bhadury, J.; Munson, C.; Mack, P. K.; Tan, T.-K.; Rehwinkel, J.; Iwama, A.; Wyss-Coray, T.; Nakauchi, H.; Wilkinson, A. C.
10.1101/2022.07.22.501030 — genetics — Posted on 2025-05-19
2034 Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery
Murad, J. P.; Christian, L.; Rosa, R.; Ren, Y.; Lee, E.; Lopez, L.; Park, A.; Yang, J.; Trac, C.; Adkins, L.; Chang, W.-C.; Martinez, C.; June, C. H.; Forman, S.; Ishihara, J.; Lee, J. K.; Stern, L.; Priceman, S. J.
10.1101/2025.04.04.647304 — bioengineering — Posted on 2025-05-19
2035 Genome divergence between European anchovy ecotypes fuelled by structural variants originating from cross-hemispheric admixture
Meyer, L.; Barry, P.; Le Moan, A.; Arbiol, C.; Castilho, R.; Van der Lingen, C. D.; Chlaïda, M.; McKeown, N. J.; Ernande, B.; Bonhomme, F.; Gagnaire, P.-A.; Guinand, B.
10.1101/2024.09.15.613121 — evolutionary biology — Posted on 2025-05-19
2036 A piRNA modulates the levels of 20-hydroxyecdysone in the ovary of the German cockroach
Gonzalvo, J.; Farrus, N.; Escudero, J.; Berkova, P.; Moos, M.; Nouzova, M.; Noriega, F.; Pujal, D.; Bau, J.; Piulachs, M.-D.
10.1101/2024.10.10.617606 — developmental biology — Posted on 2025-05-19
2041 Explaining tip-of-the-tongue experiences in older adults: contributions of brain function, structure, and perfusion in relation to older adults cardiorespiratory fitness
Rahman, F.; Tsvetanov, K. A.; Feron, J.; Mullinger, K.; Joyce, K.; Gilani, A.; Fernandes, E. G.; Wetterlin, A.; Wheeldon, L. R.; Lucas, S. J. E.; Segaert, K.
10.1101/2023.12.08.570799 — neuroscience — Posted on 2025-05-19
2042 Personalized whole-brain models of seizure propagation
Lopez-Sola, E.; Mercadal, B.; Lleal-Custey, E.; Salvador, R.; Sanchez-Todo, R.; Bartolomei, F.; Wendling, F.; Ruffini, G.
10.1101/2025.05.15.654238 — neuroscience — Posted on 2025-05-19
2043 Confirmation Bias through Selective Readout of Information Encoded in Human Parietal Cortex
Park, H.; Arazi, A.; Talluri, B. C.; Celotto, M.; Panzeri, S.; Stocker, A. A.; Donner, T. H.
10.1101/2024.06.21.600060 — neuroscience — Posted on 2025-05-19
2044 GCN5L1 inhibits pyruvate dehydrogenase phosphorylation during cardiac ischemia- reperfusion injury
Bugga, P.; Stoner, M.; Manning, J.; Mushala, B.; Bhattarai, N.; Sharifi-Sanjani, M.; Scott, I.
10.1101/2024.06.03.597148 — physiology — Posted on 2025-05-19
2047 Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Giladi, M.; Kredi, S.; Guardiani, C.; Aviram, L.; Vankova, P.; Man, P.; Giacomello, A.; Haitin, Y.
10.1101/2025.05.09.652838 — biochemistry — Posted on 2025-05-19
2049 A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies
Balligand, T.; Carpenet, C.; Olive Palau, S.; Jaspers, T.; Suresh, P.; Liu, X.; Medhi, H.; Lee, Y. H.; Rashidian, M.; De Strooper, B.; Ploegh, H. L.; Dewilde, M.
10.1101/2024.11.20.624506 — immunology — Posted on 2025-05-19
2052 Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy
Marrocco, R.; Patel, J.; Medari, R.; Salu, P.; Lucero-Meza, E.; Brunel, S.; Martsinkovskiy, A.; Sun, S.; Gulay, K.; Jaljuli, M.; Mose, E.; Lowy, A.; Benedict, C. A.; Hurtado de Mendoza, T.
10.1101/2025.05.15.654308 — cancer biology — Posted on 2025-05-19
2056 Congenital heart disease missense mutations in the TBX5 DNA-binding domain alter thermal stability and DNA-binding affinity
Rivera-Madera, A.; Pena-Martinez, E. G.; Messon-Bird, J. L.; Pomales-Matos, D. A.; Echevarria-Bonilla, O. L.; Sanabria-Alberto, L.; Peterson-Peguero, E. A.; Rodriguez-Martinez, J. A.
10.1101/2025.05.16.654568 — biochemistry — Posted on 2025-05-19
2057 Coexisting with humans: genomic and behavioural consequences in a small and isolated bear population
Fabbri, G.; Biello, R.; Gabrielli, M.; Torres Villaca, S.; Sammarco, B.; Fuselli, S.; Santos, P.; Ancona, L.; Peretto, L.; Padovani, G.; Sollitto, M.; Iannucci, A.; Paule, L.; Balestra, D.; Gerdol, M.; Ciofi, C.; Ciucci, P.; Mahan, C. G.; Trucchi, E.; Benazzo, A.; Bertorelle, G.
10.1101/2025.05.15.654188 — genomics — Posted on 2025-05-19
2058 Global Change Factors differentially impact Floral and Leaf Economic Traits
Manavalan, M.; Thakur, D.; Schaumberger, A.; Bahn, M.; Münzbergova, Z.
10.1101/2025.05.15.654190 — ecology — Posted on 2025-05-19
2059 Classification of indeterminate and off-target cell types within human kidney organoid differentiation
Wilson, S. B.; Vanslambrouck, J. M.; Murphy, A.; Neavin, D. R.; Powell, J. E.; Howden, S. E.; Little, M. H.
10.1101/2025.05.16.654519 — cell biology — Posted on 2025-05-19
2061 Classical Myelo-Proliferative Neoplasms emergence and development based on real life incidence and mathematical modeling
giraudier, s.; Baranda, A. F.; Bansaye, V.; Lauret, E.; Mounier, M.; Ugo, V.; Meleard, S.; Giraudier, S.
10.1101/2025.05.14.654143 — cancer biology — Posted on 2025-05-19
2063 Community-promoted antibiotic resistance genes show increased dissemination among pathogens
Lund, D.; Johnning, A.; Holmström, M.; Varghaei, L.; Inda-Diaz, J. S.; Bengtsson-Palme, J.; Kristiansson, E.
10.1101/2025.05.12.653433 — bioinformatics — Posted on 2025-05-19
2064 PREDICTING RISK OF INADEQUATE MICRONUTRIENT INTAKEWITH TRANSFERABLE MACHINE LEARNING MODELS
Voukelatou, V.; Tang, K.; Lauzana, I.; Jangid, M.; Martini, G.; de Pee, S.; Knight, F.; Piovani, D.
10.1101/2025.04.08.647715 — bioinformatics — Posted on 2025-05-19
2065 The mouse pangenome reveals the structural complexity of the murine protein coding landscape
Helmy, M.; Li, J. U.; Yan, X. F.; Meade, R. K.; Anderson, E.; Chen, P.; Czechanski, A. M.; Di Domenico, T.; Flint, J.; Garrison, E.; Guarracino, A.; Gontijo, M. T.; Haggerty, L.; Heard, E.; Howe, K.; Meena, N.; Martin, F. J.; Miska, E.; Rall, I.; Ramakrishna, N. B.; Sapetschnig, A.; Sinha, S.; Sun, D.; Tricomi, F. F.; Qu, R.; Wood, J. M.; Wu, T.; Zhou, D. J.; Reinholdt, L.; Adams, D. J.; Smith, C. M.; Lilue, J.; Keane, T. M.
10.1101/2025.05.13.653481 — genomics — Posted on 2025-05-19
2066 MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion
Quack, S.; Maity, S.; America, P. P. B.; Klein, M.; Herrero del Valle, A.; Singh, R.; Smitskamp, Q.; Papini, F. S.; Broedersz, C.; Roos, W.; Modis, Y.; Dulin, D.
10.1101/2024.08.27.609867 — biophysics — Posted on 2025-05-19
2067 difFUBAR: Scalable Bayesian comparison of adaptive evolution
Sadiq, H.; Truong, P.; Danielsson, M.; Kumar, V.; Nordlinder, H. N.; Martin, D. P.; Murrell, B.
10.1101/2025.05.19.654647 — bioinformatics — Posted on 2025-05-19
2068 Disentangling urbanisation, climate effects and their interaction on ornamental colourations
Sandmeyer, L.; Lopez-Idiaquez, D.; Fargevieille, A.; Giovannini, P.; Perret, S.; Del Rey, M.; Charmantier, A.; Doutrelant, C.; Gregoire, A.
10.1101/2025.02.19.639098 — ecology — Posted on 2025-05-19
2072 A knowledge graph and topological data analysis framework to disentangle the tomato-multi pathogens complex gene regulatory network
multari, m.; carriere, m.; Amoros-Gabarron, x.; damy, a.; lobentanzer, s.; saez-rodriguez, J.; Jaubert, S.; Dugourd, A.; BOTTINI, S.
10.1101/2025.04.09.647963 — systems biology — Posted on 2025-05-19
2075 Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy
Nguyen, T. T. H.; Huang, Y. X.; Poliakova, S.; Citu, C.; Mann, E.; Sopariwala, D. H.; Zhao, Z.; Kumar, A.; NARKAR, V. A.
10.1101/2025.05.15.654390 — physiology — Posted on 2025-05-19
2076 Skeletal muscle proteomic responses to energy deficit with concomitant aerobic exercise in humans
Nishimura, Y.; Langan-Evans, C.; Taylor, H. L.; Lun Foo, W.; Morton, J. P.; Shepherd, S.; Strauss, J.; Burniston, J. G.; Areta, J. L.
10.1101/2025.05.15.654297 — physiology — Posted on 2025-05-19
2077 Ancient and recent riverine gene flow contributed to the adaptive radiation of sailfin silversides in Wallace's Dreampond
De Keyzer, E. L. R.; Herder, F.; Boehne, A.; Campuzano Jimenez, F.; Burskaia, V.; Kukowka, S.; Tracey, A.; Denton, A. L.; Oatley, G.; Tree of Life programme, ; Scientific Operations: DNA Pipelines collective, ; Core Informatics collective, ; Mokodongan, D. F.; Wowor, D.; Svardal, H.
10.1101/2025.04.16.648611 — evolutionary biology — Posted on 2025-05-19
2079 Too much sugar makes plants "pregnant": maternal sucrose signals fertilization in Arabidopsis seeds
Xu, W.; Iannaccone, M.; Gomez-Paez, D.-M.; Choinard, S.; Lu, J.; Le Hir, R.; Dinant, S.; Kalmbach, L.; Feil, R.; E. Lunn, J.; Meyer, C.; Magnani, E.
10.1101/2025.05.16.654273 — plant biology — Posted on 2025-05-19
2080 Enhanced cell aggregation in the Chlamydomonas reinhardtii rbo1 mutant in response to multifactorial stress combination
Pascual, L. S.; Mohanty, D.; Sinha, R.; Nguyen, T. T.; Rowland, L.; Lyu, Z.; Joshi, T.; Mooney, B. P.; Gomez-Cadenas, A.; Fritschi, F. B.; Zandalinas, S. I.; Mittler, R.
10.1101/2025.05.16.654601 — plant biology — Posted on 2025-05-19
2081 RBP47 family members are negative regulators of heat stress tolerance in Arabidopsis thaliana
Hernandez-Sanchez, I. E.; Tarbiyyah, I.; Kearly, A.; Martinez-Seidel, F.; Maruri-Lopez, I.; Chen, Y.; S. Rissland, O.; Wang, W.; Sioud, S.; Schwarzenberg, A.; Nelson Dittrich, A. C.; Nelson, A.; Chodasiewicz, M.
10.1101/2025.05.18.654719 — plant biology — Posted on 2025-05-19
2084 Vascular anatomy changes in tomato stems grown under simulated microgravity
Hostetler, A. N.; Kennebeck, E.; Reneau, J. W.; Caldwell, D. L.; Iyer-Pascuzzi, A. S.; Sparks, E. E.
10.1101/2025.05.16.654566 — plant biology — Posted on 2025-05-19
2085 Diploid gametes in maize by mutation of A-Type cyclins: a step towards apomeiosis and synthetic apomixis.
Skinner, D. J.; Gaikwad, A. H.; Fenner, J. A.; Green, J.; Cho, M.-J.; Kelliher, T.; Sundaresan, V.
10.1101/2025.05.16.654085 — plant biology — Posted on 2025-05-19
2086 The Role of SIAMESE in G2 Checkpoint Regulation in Arabidopsis thaliana
Schwall, M. A.; Clark, F.; Dale, R.; Roeder, A. H. K.; Kato, N.; Larkin, J. C. C.
10.1101/2025.05.16.654532 — plant biology — Posted on 2025-05-19
2088 The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels
Sauer, J.; Marksteiner, J.; Hohenegger, M.; Todt, H.; Kubista, H.; Dostal, C.; Kiss, A.; Podesser, B. K.; Salzer, I.; Koenig, X.; Stary-Weinzinger, A.; Hilber, K.; Kudlacek, O.
10.1101/2025.05.15.654221 — pharmacology and toxicology — Posted on 2025-05-19
2089 Quantitative evaluation of dogs as sentinels for Rift Valley fever virus circulation in Madagascar
Ramaroson, H. S.; Garchitorena, A.; Lacoste, V.; Andriamandimby, S. F.; Schoenhals, M.; Bastard, J.; Albrechtova, K.; Chevalier, L.; Rakotomanana, D.; Rasamoel, P. d. V.; Raliniaina, M.; Andriamahefa, H. F.; Andriamananjara, M. A.; Rasoloharimanana, L. T.; Razafimahatratra, S. L.; Ratsimbasoa, C. A.; Durand, B.; Chevalier, V.
10.1101/2025.05.16.654436 — pathology — Posted on 2025-05-19
2092 AI assisted design of ligands for Lipocalin-2
Sgrignani, J.; Buscarini, S.; Locatelli, P.; Guerra, C.; Furlan, A.; Chen, Y.; Zoppi, G.; Cavalli, A.
10.1101/2025.05.18.654718 — biochemistry — Posted on 2025-05-19
2093 Identification and Rescue of Congenital Hyperinsulinism-Associated ABCC8 Mutations that Impair KATP Channel Trafficking
ElSheikh, A.; Kuo, Y.-Y.; E. Boodhansingh, K.; Yang, Z.; A. Stanley, C.; De Leon, D. D.; Shyng, S.-L.
10.1101/2025.05.18.654760 — biochemistry — Posted on 2025-05-19
2095 DNA methylation marks associated with body composition in children from India and the Gambia - findings from the EMPHASIS study
Issarapu, P.; Arumalla, M.; Antoun, E.; di Gravio, C.; Ward, K.; Fall, C. H. D.; Prentice, A. M.; Chandak, G. R.; Silver, M. J.
10.1101/2025.05.15.654252 — genomics — Posted on 2025-05-19
2096 Sex-Specific Differential DNA Methylation in Mild Cognitive Impairment and Alzheimers Disease
Bergmann, P. E.; Madrid, A.; Papale, L. A.; Clark, L. R.; Asthana, S.; Johnson, S. C.; Keles, S.; Hogan, K.; Alisch, R. S.
10.1101/2025.05.15.654279 — genomics — Posted on 2025-05-19
2100 Personalized whole-brain models of seizure propagation
Lopez-Sola, E.; Mercadal, B.; Lleal-Custey, E.; Salvador, R.; Sanchez-Todo, R.; Bartolomei, F.; Wendling, F.; Ruffini, G.
10.1101/2025.05.15.654238 — neuroscience — Posted on 2025-05-19
2102 Immune Spatial Organization Predicts Metastasis Risk in Aggressive Localized Prostate Cancer
Yang, D. D.; Abdelnaser, A.; Wala, J.; Haas, A. J.; Barney, A. A.; Saad, E.; Crowdis, J. P.; Ricker, C. A.; Park, J.; King, M. T.; Nguyen, P. L.; Choueiri, T. K.; Tewari, A. K.; Salari, K.; Taplin, M.-E.; Wu, C.-L.; Van Allen, E. M.
10.1101/2025.05.15.654324 — bioinformatics — Posted on 2025-05-19
2105 Genomic insights into Plasmodium vivax and Plasmodium simium host shifts in Latin America
Lefebvre, M. J. M.; Degrugillier, F.; Arnathau, C.; Gonzalez, C. J. M.; Rondon, S.; Link, A.; Chaves, A.; Benavides, J. A.; Campos, A. A. S.; dos Santos, E.; Huff, R.; Silva, C. M. D.; Vanderheoven, E.; de Thoisy, B.; Fontaine, M. C.; Prugnolle, F.; Rougeron, V.
10.1101/2024.12.19.629455 — evolutionary biology — Posted on 2025-05-19
2107 Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats
Caldwell, A.; Yang, L.; Casazza, R. L.; Worota, R. E.; McCutcheon, C.; Creisher, P. S.; Zhan, E.; Reasoner, C.; Higgins, A.; Schountz, T.; Coyne, C. B.
10.1101/2025.05.15.654282 — developmental biology — Posted on 2025-05-19
2109 Unveiling immune interference: How the dendritic cell response to co-infection with Aspergillus fumigatus is modulated by human cytomegalovirus and its virokine CMVIL-10
Heilig, L.; Bussemer, L.; Strobel, L.; Huenniger, K.; Kurzai, O.; Grothey, A.; Doelken, L.; Laib, K.; Panagiotou, G.; Westermann, A.; Einsele, H.; Wurster, S.; Schaeuble, S.; Loeffler, J.
10.1101/2025.05.15.654194 — immunology — Posted on 2025-05-19
2110 Proprioceptive limit detectors mediate sensorimotor control of the Drosophila leg
Pratt, B. G.; Dallmann, C. J.; Chou, G. M.; Siwanowicz, I.; Walling-Bell, S.; Cook, A.; Sustar, A.; Azevedo, A.; Tuthill, J. C.
10.1101/2025.05.15.654260 — neuroscience — Posted on 2025-05-19
2114 SWANS: A highly configurable analysis pipeline for single-cell and single-nuclei RNA-sequencing data
Beigel, K.; Wafula, E.; Mitchelle, D. V.; Pastor, S. J.; Gong, M.; Heuckeroth, R.; Ricarte-Filho, J. C.; Franco, A. T.; Reichenberger, E. R.
10.1101/2025.05.14.654073 — bioinformatics — Posted on 2025-05-19
2117 ASPPs multimerize protein phosphatase 1
Wei, D. T.; Morrison, K. N.; Beacham, G. M.; Beyrent, E.; Zhang, Y.; Florens, L.; Hollopeter, G.
10.1101/2025.05.16.654433 — cell biology — Posted on 2025-05-19
2118 The 18S rRNA methyltransferase, BUD23, is required for appropriate lipid and mitochondrial metabolism
Martinez-Sanchez, N.; Brümmer, A.; Barron, N. J.; Rosoff, D. B.; Liechti, A.; Voronkov, M.; Hayter, E. A.; Chamois, S.; Dreos, R.; Guex, N.; Johnson, E.; Baxter, M.; Smith, K.; Northeast, R. C.; Galli, G.; Hodson, L.; Gatfield, D.; Ray, D.; Bechtold, D.
10.1101/2025.05.16.654455 — cell biology — Posted on 2025-05-19
2119 Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage
Guest, S. L.; Velle, K. B.; Jacques, S. M.; Park, Y.; Man, J.; Titus, M. A.; Fritz-Laylin, L.
10.1101/2025.05.16.654244 — cell biology — Posted on 2025-05-19
2120 Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens
Kulicke, C. A.; Lemon, C.; Krawic, J. R.; Ramirez, L. M. N.; Kim, S.-J.; Narayanan, G. A.; Tafesse, F. G.; Hildebrand, W. H.; Dobos, K. M.; Lewinsohn, D. M.
10.1101/2025.05.14.654109 — immunology — Posted on 2025-05-19
2121 Dietary glutamine supplementation alleviates age-related cardiac dysfunction by reducing elevated H3K27me3
Le, C.; Coleman, P.; Burgoyne, T.; Su, J.; Warren, H. R.; Kumar, R.; Oexner, R. R.; Ahn, H.; Ntorla, A.; Santos, C. X. C.; Shah, A. M.; Giacca, M.; Ehler, E.; Burgoyne, J. R.
10.1101/2025.05.16.654624 — cell biology — Posted on 2025-05-19
2123 ER-Localized Ceramide Accumulation Due to Disrupted CERT Transport Contributes to Replicative Senescence
Chitkara, S.; Gozali, N.; Kuzmin, A.; Pliss, A.; Prasad, P.; Sancak, Y.; Atilla-Gokcumen, G. E.
10.1101/2025.05.16.654528 — cell biology — Posted on 2025-05-19
2124 The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
Ritacco, D. A.; Shahnawaz, H.; Oduguwa, A.; Hawk, J. S.; Vizcaino, B.; Farber, D. L.; Gaudet, R. G.
10.1101/2025.05.16.654477 — cell biology — Posted on 2025-05-19
2130 Role of channels in the O2 permeabilityof murine red blood cells. I. Stopped-flow and hematological studies
Zhao, P.; Moss, F. J.; Occhipinti, R.; Geyer, R. R.; Huffmann, D. E.; Meyerson, H. J.; Boron, W. F.
10.1101/2025.03.05.639948 — physiology — Posted on 2025-05-18
2133 FSCN1-Mediated Hepatic Gluconeogenesis Is Indispensable for Neonatal Mice Survival
Liu, X.; HU, Y.; Wu, L.; Zhang, Y.; Sang, L.; Gao, Y.; He, L.; Yang, S.; Xiong, W.; Sun, j.
10.1101/2025.05.18.654691 — molecular biology — Posted on 2025-05-18
2134 Telomerase reverse transcriptase is required for resistance to mycobacterial infection
Han, D. J.; Costa, D. M.; Luo, G.; Wright, K.; Pandey, M.; Wee, D.; Chen, Y.; Akincilar, S. C.; Tergaonkar, V.; Dorajoo, R.; Carissimo, G.; Singhal, A.; Elks, P. M.; Ellis, P. S.; Henriques, C. M.; Yan, B.; Mostowy, S.; Oehlers, S. H.
10.1101/2025.05.15.654386 — immunology — Posted on 2025-05-18
2136 Characterizing the frequency-specific and spatiotemporal dynamics of β-γ Phase-Amplitude Coupling in Parkinson's disease
Loehrer, P. A.; Yassine, S.; Weber, I.; Sanner, V.; He, S. A.; Pogosyan, A.; Chen, L.; Witt, L.; Fink, G. R.; Pedrosa, D. J.; Timmermann, L.; Tan, H.
10.1101/2025.05.14.653744 — neuroscience — Posted on 2025-05-18
2138 Role of channels in the O2 permeability of murine red blood cells II. Morphological and proteomic studies
Moss, F. J.; Zhao, P.; Salameh, A. I.; Taki, S.; Wass, A. B.; Jacobberger, J. W.; Huffman, D. E.; Meyerson, H. J.; Occhipinti, R.; Boron, W. F.
10.1101/2025.03.05.639962 — physiology — Posted on 2025-05-18
2139 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes
Rippa, A.; Posgai, A. L.; Currlin, S.; Brusko, M.; Williams, M. D.; Kaddis, J. S.; Kusmartseva, I.; Wasserfall, C. H.; Campbell-Thompson, M.; Atkinson, M. A.
10.1101/2025.05.14.654045 — pathology — Posted on 2025-05-18
2140 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA
Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.
10.1101/2024.11.25.625221 — paleontology — Posted on 2025-05-18
2141 Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species
Ruoff, C.; Mitchell, A.; Mondal, P.; Gopalan, V.; Singh, A.; Gottesman, M.; Hannenhalli, S.
10.1101/2024.07.05.602281 — cancer biology — Posted on 2025-05-18
2142 Neural function of Netrin-1 in precancerous lesions of the pancreas
Haidar, H.; Bellon, A.; Sleiman, K.; Hocine, M.; Rama, N.; Gadot, N.; Carpizo, D. R.; Mehlen, P.; Mann, F.
10.1101/2025.05.14.654046 — cancer biology — Posted on 2025-05-18
2143 Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer
Zennami, K.; Graham, M. K.; Chikara, S.; Sysa-Shah, P.; Rafiqi, F. H.; Wang, R.; Abel, B.; Zeng, Q.; Krueger, T. E. G.; Brennen, W. N.; Ganguly, S.; Zarif, J. C.; Simons, B.; DeWeese, T. L.; De Marzo, A.; Yegnasubramanian, S.; Lupold, S. E.
10.1101/2025.05.14.654101 — cancer biology — Posted on 2025-05-18
2145 InstaNovo-P: A de novo peptide sequencing model for phosphoproteomics
Lauridsen, J.; Ramasamy, P.; Catzel, R.; Canbay, V.; Mabona, A.; Eloff, K.; Fullwood, P.; Ferguson, J.; Kirketerp-Moller, A.; Goldschmidt, I. S.; Claeys, T.; van Puyenbroeck, S.; Lopez Carranza, N.; Schoof, E. M.; Martens, L.; Van Goey, J.; Francavilla, C.; Jenkins, T. P.; Kalogeropoulos, K.
10.1101/2025.05.14.654049 — bioinformatics — Posted on 2025-05-18
2146 Snekmer Learn/Apply: A kmer-based vector similarity approach to proteinclassification suitable for metagenomic datasets
Nitka, T. A.; Jacobson, J.; Chang, C. H.; Krause, G. R.; Wheeler, T. J.; Egbert, R. G.; Nelson, W. C.; McDermott, J. E.
10.1101/2025.05.16.654600 — bioinformatics — Posted on 2025-05-18
2147 Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice
Hedaya, O. M.; Jiang, F.; Baliga, U.; Ivanov, A.; Chen, S.; Schwartz, J.; Kawakami, Y.; Yan, C.; Yao, P.
10.1101/2025.05.18.654700 — biochemistry — Posted on 2025-05-18
2148 An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference
Alemu, R.; Terskaya, A.; Howell, M.; Guan, J.; Sands, H.; Kleinman, A.; 23andMe Research Team, ; Bann, D.; Morris, T.; Ploubidis, G. B.; Fitzsimons, E.; Mullan Harris, K.; Caspi, A.; Corcoran, D. L.; Moffitt, T. E.; Poulton, R.; Sugden, K.; Williams, B. S.; Steptoe, A.; Ajnakina, O.; Vainik, U.; Esko, T.; Estonian Biobank Research Team, ; Campbell, A.; Hayward, C.; Iacono, W. G.; McGue, M.; Krueger, R. F.; Docherty, A. R.; Shabalin, A. A.; Hertwig, R.; Koellinger, P.; Richter, D.; Goebel, J.; Ahlskog, R.; Oskarsson, S.; Magnusson, P. K. E.; Harden, K. P.; Tucker-Drob, E. M.; Pahnke, C. K. L.
10.1101/2025.05.14.653986 — genomics — Posted on 2025-05-18
2150 Genetic effects on migration behaviour contribute to increasing spatial differentiation at trait-associated loci in Estonia
Kuznetsov, I. A.; Estonian Biobank Research Team, ; Metspalu, M.; Vainik, U.; Pagani, L.; Montinaro, F.; Pankratov, V.
10.1101/2023.10.25.564036 — genetics — Posted on 2025-05-18
2152 Embryonic Stem Cell-Specific Responses to DNA Replication Stress
James, R. C.; Wang, J. K.; Bhatt, S. R.; Shadid, S. E.; Phuong, D. J.; Schimenti, J. C.
10.1101/2025.05.16.654332 — cell biology — Posted on 2025-05-18
2153 SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation
Mack, R.; Flores, N. M.; Fox, G. C.; Dong, H.; Cebeci, M.; Hausmann, S.; Chasan, T.; Dowen, J.; Strahl, B. D.; Mazur, P. K.; Gozani, O.
10.1101/2025.05.16.654513 — molecular biology — Posted on 2025-05-18
2155 TERRA transcripts and promoters from telomeric and interstitial sites
Santagostino, M.; Sola, L.; Cappelletti, E.; Gennari, N.; Piras, F. M.; Biundo, M.; Nergadze, S. G.; Giulotto, E.
10.1101/2025.05.15.654290 — molecular biology — Posted on 2025-05-18
2157 Real-time Visualization of Trigger Factor on Translating Ribosomes
Nunez, E.; Saha, P.; G.Ibarluzea, M.; Muguruza-Montero, A.; M.Alicante, S.; Ramis, R.; Leonardo, A.; Bergara, A.; Villarroel, A.; Rico, F.
10.1101/2025.05.16.654432 — molecular biology — Posted on 2025-05-18
2158 Unique TMJ-specific transcriptomic signature and its medial layer: Implications in osteoarthritis
Raut, R. D.; Choudhury, C.; Chakraborty, A. K.; Singh, H.; Mehra, P.; Gerstenfeld, L.; Almarza, A.; Bais, M. V.
10.1101/2025.05.18.654737 — molecular biology — Posted on 2025-05-18
2161 Elucidating the Mechanism by Which HIV-1 Nucleocapsid Mutations Confer Resistance to Integrase Strand Transfer Inhibitors
Hikichi, Y.; Burdick, R. C.; Patro, S. C.; Ding, S.-Y.; Luke, B. T.; Clark, E.; Ablan, S. D.; Wu, X.; Pathak, V. K.; Freed, E. O.
10.1101/2025.05.17.654662 — microbiology — Posted on 2025-05-18
2162 Gut microbial conversion of dietary elderberry extract to hydrocinnamic acid improves obesity-associated metabolic disorders
Alqudah, S.; DeLucia, B.; Osborn, L. J.; Markley, R. L.; Bobba, V.; Preston, S. M.; Thambidurai, T.; Nia, L. H.; Fulmer, C. G.; Sangwan, N.; Nemet, I.; Claesen, J.
10.1101/2025.05.18.654739 — microbiology — Posted on 2025-05-18
2164 Sea-ice microbial community succession and the potential role of parasitoids in the maintenance of diversity
Dilliplaine, K.; Whitmore, L.; Aguilar-Islas, A.; Bolt, C.; Dumack, K.; Jin, M.; Kaufman, M.; Oggier, M.; Hennon, G.
10.1101/2025.05.18.654361 — microbiology — Posted on 2025-05-18
2165 High-resolution laminar recordings reveal structure-function relationships in monkey V1
Carr, N.; Zhu, S.; Lee, E. K.; Xia, R.; Chen, X.; Perliss, A.; Moore, T.; Chandrasekaran, C.
10.1101/2025.05.14.653875 — neuroscience — Posted on 2025-05-18
2166 Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5
Musgrove, M. R. B.; Leighton, L. J.; Liau, W.-S.; Walsh, A. D.; Marshall, P. R.; Heyworth, S. M.; Bademosi, A. T. D.; Hertrich, N.; Zhao, Q.; Madugalle, S. U.; Periyakaruppiah, A.; Li, X.; Davies, J. W. A.; Ren, H.; Gong, H.; Meunier, F.; Mikhaylova, M.; Bredy, T.
10.1101/2025.05.16.654162 — neuroscience — Posted on 2025-05-18
2170 Probing protein-protein interactions with drag flow: A case study of F-actin and tropomyosin
Bages, C.; Chabanon, M.; Kools, W.; Dos Santos, T.; Pages, R.; Sirkia, M. E.; Leduc, C.; Houdusse, A.; Jegou, A.; Romet-Lemonne, G.; Wioland, H.
10.1101/2025.05.14.653996 — biophysics — Posted on 2025-05-18
2174 An Anisotropic Reactive Viscoelastic Model of the Rhesus Macaque Cervix for Studying Cervical Remodeling
Cordon, C. A. D.; Fang, S.; Rosado-Mendez, I. M.; Ateshian, G.; Hall, T. J.; Feltovich, H.; Myers, K. M.
10.1101/2025.05.14.654071 — bioengineering — Posted on 2025-05-18
2175 Molecular basis behind the isoprene emission diversity in Fagaceae
Koita, S.; Munakata, R.; Fukushima, K.; Nagano, A. J.; Ikezaki, Y.; Satake, A.; Saito, T.; Miura, K.; Sugiyama, A.; Yazaki, K.
10.1101/2025.05.17.654689 — biochemistry — Posted on 2025-05-18
2177 Multi ligand sensing by a bacterial histidine kinase through inhibition of dimerization
Sankhe, G. D.; Xing, J.; Xiao, M.; Buglino, J. A.; Li, H.; Jouline, I.; Glickman, M.
10.1101/2025.05.18.654591 — microbiology — Posted on 2025-05-18
2178 The polyamine naphthyl-acetyl spermine trihydrochloride (NASPM) lacks specificity for Ca2+-permeable AMPA receptors and suppresses seizure like activity in human brain tissue by inhibition of NMDA receptors.
Podesta, A.; Monni, L.; Arnold, F. L.; Arnold, J.; Bertelli, S.; xu, R.; Onken, J.; Thomale, U.-W.; Kalbhenn, T.; Simon, M.; Sauvigny, T.; Alle, H.; Plested, A. J.; Holtkamp, M.; Geiger, J. R.; Fidzinski, P.
10.1101/2025.05.14.653650 — neuroscience — Posted on 2025-05-18
2179 Longitudinal single-cell analysis reveals RUNX1T1 as an early driver in treatment-induced neuroendocrine transdifferentiation
Ni, Y.; Lin, D.; Shi, M.; Lin, Y.-Y.; Xue, H.; Dong, X.; Liu, L.; Sar, F.; Wu, R.; Morova, T.; Haegert, A.; Bell, R.; Pang, X.; Classen, A.; Wang, Y.; Chen, J.; Volik, S.; Bihan, S. L.; Lack, N.; Ong, C.; Wang, G.; Zeng, H.; Collins, C.; Wang, Y.
10.1101/2025.05.14.653660 — cancer biology — Posted on 2025-05-18
2180 Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression
Jolly, J. T.; Al-Hamaly, M. A.; Smith, C. N.; Spielmann, H. P.; Blackburn, J. S.
10.1101/2025.05.14.654016 — cancer biology — Posted on 2025-05-18
2181 A Spectral Image Scanning Microscope for Multi-Color High-Resolution Imaging
Bram, L.; Tal-Friedman, O.; Fibeesh, N.; Bar-Sinai, Y.; Flaxer, E.; Roichman, Y.; Ebenstein, Y.; Jeffet, J.
10.1101/2025.05.14.653993 — biophysics — Posted on 2025-05-18
2183 Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease
Mahajan, A.; Ratti, F.; Wang, B.; El-Samad, H.; Kaufman, J. H.; Gopalakrishnan, V.
10.1101/2025.05.14.654062 — bioinformatics — Posted on 2025-05-18
2185 Ambient Light Impacts Innate Behaviors of New-World and Old-World Mice
Reinhard, K.; Vastenavondt, R.; Crevits, B.; De Boever, S.; Liao, P.-Y.; Tortella, L.; Farrow, K.
10.1101/2025.05.14.653927 — neuroscience — Posted on 2025-05-18
2187 Modeling Immunosenescence on-a-chip: a platform for cancer vaccine efficacy assessment
Maity, S.; Hassani Najafabadi, A.; Kawakita, S.; Khorsandi, D.; Yilgor, C.; Jewell, C.; Mohaghegh, N.; Dokmeci, M. R.; Khademhosseini, A.; Jucaud, V.
10.1101/2025.05.14.654059 — bioengineering — Posted on 2025-05-18
2189 The decameric repeat (DR) of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity
Han, Y.; Sealey, L.; Fu, Y.; Delfing, B. M.; Lockhart, C.; Chilin, L.; Tiwari, S.; Jafri, M. S.; Klimov, D.; Wu, Y.
10.1101/2025.05.14.654117 — immunology — Posted on 2025-05-18
2190 In-vivo evidence for increased tau deposition in temporal lobe epilepsy
Cruces, R. R.; Lam, J.; Arafat, T.; Royer, J.; Chen, J.; Sahlas, E.; Dascal, A.; Pana, R.; Hopewell, R.; Hsiao, C. H.-H.; Massarweh, G.; Soucy, J.-P.; Villeneuve, S.; Caciagli, L.; Koepp, M. J.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B.
10.1101/2025.05.14.654095 — neuroscience — Posted on 2025-05-18
2191 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA
Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.
10.1101/2024.11.25.625221 — paleontology — Posted on 2025-05-18
2192 Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity
Karagiannis, T. T.; Chen, Y.; Bald, S.; Tai, A.; Milman, S.; Andersen, S. L.; Perls, T. T.; Segre, D.; Sebastiani, P.; Short, M. I.
10.1101/2025.05.14.654104 — bioinformatics — Posted on 2025-05-18
2193 fMRIPrep Lifespan: Extending A Robust Pipeline for Functional MRI Preprocessing to Developmental Neuroimaging
Goncalves, M.; Moser, J.; Madison, T. J.; McCollum, r.; Lundquist, J. T.; Fayzullobekova, B.; Hadera, L.; Pham, H. H. N.; Moore, L. A.; Houghton, A. M.; Conan, G.; Styner, M. A.; Alexopoulos, D.; Smyser, C. D.; Stoyell, S. M.; Koirala, S.; Nelson, S. M.; Weldon, K. B.; Lee, E.; Hermosillo, R. J. M.; Vizioli, L.; Yacoub, E.; Patel, G. H.; Sanchez, J.; Wengler, K.; Salo, T.; Satterthwaite, T. D.; Elison, J. T.; Markiewicz, C. J.; Poldrack, R. A.; Feczko, E.; Esteban, O.; Fair, D. A.
10.1101/2025.05.14.654069 — bioinformatics — Posted on 2025-05-18
2195 Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery
Hall, L. A.; Guenter, R.; Queiroz, R. G.; Jackson, A.; Golivi, Y.; Watts, J.; Zhang, Y.; Rathbun, L.; Rose, J. B.; Larimer, B. M.
10.1101/2025.05.14.654066 — bioengineering — Posted on 2025-05-18
2196 Comparative Analysis of Indole Derivative Production Among Clinical Isolates of Fusobacterium nucleatum
Scano, C. J.; Choudhury, A.; Rojo, M.; Lavado, R.; Zaharas, G.; Hawkins, J.; Greathouse, L.
10.1101/2025.05.16.654558 — microbiology — Posted on 2025-05-18
2197 Multi-level orchestration of γδ T cell development and central nervous system inflammation by retinoic acid
Fares da Silva, M. G. F.; Agerholm, R.; Sumaria, N.; Rizk, J.; Fiske, J.; Catafal-Tardos, E.; Baglioni, M. V.; Secci, D.; Sebastian, P. P.; Pennington, D.; Bekiaris, V.
10.1101/2020.08.12.247510 — immunology — Posted on 2025-05-18
2198 Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer
Banik, D.; Ward, C.; Zhang, Z.; Chakraborty, S.; Heraghty, D.; Suresh, P.; Li, B.; Kedia, S.; Davis, S.; Roy, J.; Chapman, M.; Mahata, B.; Klenerman, D.
10.1101/2024.08.29.610222 — immunology — Posted on 2025-05-18
2199 Potent neutralization of Marburg virus by a vaccine-elicited monoclonal antibody
Addetia, A.; Perruzza, L.; Park, Y.-J.; McCallum, M.; Stewart, C.; Brown, J. T.; Donati, A.; Culap, K.; Balmelli, A.; Gazi, M.; Carrion, R.; Corti, D.; Benigni, F.; Veesler, D.
10.1101/2025.05.14.654121 — immunology — Posted on 2025-05-18
2200 Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors
Mishra, D. K.; Morris, S. M.; Popovski, D.; Girard, E. J.; Bondoc, A.; Kumar, S. S.; Andrade, A. F.; Zhu, X.; Yao, F.; Brusniak, M.-Y.; Umaru, B.; Crotty, E. E.; Brasel, K.; Pakiam, F.; Russo, C.; Zeinieh, M.; Biery, M. C.; Coxon, M.; Conti, H.; Clarke, M.; Lu, M.; Rutka, J.; Llivichuzhca-Loja, D.; Konnikova, L.; Fouladi, M.; Jabado, N.; Huang, A.; Olson, J. M.; Drissi, R.
10.1101/2025.05.14.654106 — immunology — Posted on 2025-05-18
2202 T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma
Sywanycz, S.; Hill, B. L.; Miller, Z. A.; Turner, G.; Huang, L.; Polen, K.; Lee, R. J.; Carey, R. M.
10.1101/2025.05.14.654120 — cancer biology — Posted on 2025-05-18
2205 Comparative Analysis of Indole Derivative Production Among Clinical Isolates of Fusobacterium nucleatum
Scano, C. J.; Choudhury, A.; Rojo, M.; Lavado, R.; Zaharas, G.; Hawkins, J.; Greathouse, L.
10.1101/2025.05.16.654558 — microbiology — Posted on 2025-05-18
2206 Accelerated design of Escherichia coli genomes with reduced size using a whole-cell model and machine learning
Gherman, I. M.; Sharma, K.; Rees-Garbutt, J. P.; Pang, W.; Abdallah, Z. S.; Gorochowski, T. E.; Grierson, C. S.; Marucci, L.
10.1101/2023.10.30.564402 — bioengineering — Posted on 2025-05-18
2208 Intracellular pH modulates vimentin remodeling in response to oxidants
Martinez, A. E.; Martinez-Cenalmor, P.; Gonzalez-Jimenez, P.; Vidal-Verdu, C.; Pajares, M. A.; Perez-Sala, D.
10.1101/2023.12.21.572888 — cell biology — Posted on 2025-05-18
2211 Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons
Souza, G. M. P. R.; Thakkalapally, H.; Berry, F. E.; Atongazi, U. M.; Stornetta, D. S.; Abbott, S. B. G.
10.1101/2025.05.14.654157 — neuroscience — Posted on 2025-05-18
2212 PATZ1 Reinstates a Growth-Permissive Chromatin Landscape in Adult Corticospinal Neurons After Injury
Menon, A. S.; Kumaran, M.; Beji, D. S.; Kesireddy, D. K.; Sahu, Y.; Banerjee, S.; Manjunath, S.; Sanyal, K.; Konda, M.; Venkatesh, I.
10.1101/2025.05.14.654166 — neuroscience — Posted on 2025-05-18
2214 Early development of the glucocorticoid stress response in dyeing poison frog tadpoles
Surber, L. L.; Jimenez, L. S.; Mobo, L. W.; Westrick, S. E.; Fischer, E. K.
10.1101/2024.05.31.596457 — physiology — Posted on 2025-05-18
2215 Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin's biochemical activity without changing thick filament structure
Mohran, S.; Kooiker, K. B.; Naim, A.; Pilagov, M.; Asencio, A.; Turner, K.; ma, w.; Flint, G. V.; Jiang, S.; Zhao, J.; McMillen, T. S.; Mandrycky, C.; Mahoney-Schaefer, M.; Irving, T.; Tanner, B. C. W.; Kad, N. M.; Regnier, M.; Moussavi-Harami, F.
10.1101/2025.05.14.654110 — biophysics — Posted on 2025-05-18
2222 A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity
Shimanaka, Y.; Tol, M. J.; Rocha-Roa, C.; Jellinek, M. J.; Cui, L.; Bender, A.; Bedard, A. H.; Milner, M. G.; Melillo, B.; Shoucri, B. M.; Wong, A.; Williams, K. J.; Stiles, L.; Shum, M.; Weston, T. A.; Cohn, W.; Whitelegge, J. P.; Budin, I.; Bertholet, A. M.; Cravatt, B. F.; Young, S. G.; Houten, S. M.; Argmann, C.; Ford, D. A.; Liesa, M.; Shirihai, O. S.; Vanni, S.; Tontonoz, P.
10.1101/2025.05.15.654206 — physiology — Posted on 2025-05-18
2225 Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancer
Salehi, S.; Stroobant, E. E.; Lees, H.; Lin, Y.-H.; Shimada, S.; Abate, M.; Zatzman, M. J.; Ceglia, N.; Freeman, S.; Laszkowska, M.; Maron, S. B.; McPherson, A.; Rusk, N.; Havasov, E.; Drebin, H.; Gu, P.; Tang, L. H.; Janjigian, Y. Y.; Soldatov, R.; Chaligne, R.; Shah, S. P.; Strong, V. E.; Vardhana, S. A.
10.1101/2025.05.05.651897 — immunology — Posted on 2025-05-18
2226 IFNγ regulates MR1 transcription and antigen presentation
Huber, M. E.; Larson, E. A.; Lust, T. N.; Heisler, C. M.; Harriff, M. J.
10.1101/2025.02.09.637183 — immunology — Posted on 2025-05-18
2228 Cardiac Adaptations in the Cave Nectar Bat Eonycteris spelaea: Insights into Metabolic Resilience and Stress Response
Yu, F.; Gamage, A. M.; Kp, M. M. J.; Foo, R.; Lin, Y.-H.; Wang, L.; Pua, C. J.; Chan, W.; Crespo-Avilan, G. E.; Pena, E. M.; Hong, L. Z.; Iyer, A.; Ghosh, S.; Liehn, E. A.; Kovalik, J.-P.; Wang, L.-F.; Ramachandra, C. J.; Hausenloy, D. J.
10.1101/2025.05.15.653669 — systems biology — Posted on 2025-05-18
2229 Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry
Boatman, A. K.; Chappel, J. R.; Kirkwood-Donelson, K. I.; Fleming, J. F.; Reif, D. M.; Schymanski, E. L.; Rager, J. R.; Baker, E.
10.1101/2025.01.27.634925 — scientific communication and education — Posted on 2025-05-18
2230 Intercellular compartmentation of trehalose 6-phosphate metabolism in Setaria viridis leaves
Tonetti, T.; Rojas, B. E.; Feil, R.; Seimandi, C.; Lucero, L. E.; Cabello, J. V.; Calace, P.; Saigo, M.; Arrivault, S.; Stitt, M.; Lunn, J. E.; Figueroa, C. M.
10.1101/2024.08.16.608293 — plant biology — Posted on 2025-05-18
2235 Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast
Benning, F. M. C.; Bell, T. A.; Nguyen, T. H.; Syau, D.; Connell, L. B.; Liao, Y.-T.; Keating, M.; Coughlin, M.; Nordstrom, A. E. H.; Ericsson, M.; daCosta, C. J. B.; Chao, L. H.
10.1101/2024.04.26.591372 — evolutionary biology — Posted on 2025-05-18
2236 Jumbo phage-mediated transduction of genomic islands
Zhao, Y.; Ma, Y.; Vasileiou, C.; Farr, A. D.; Rogers, D. W.; Rainey, P. B.
10.1101/2024.08.29.610337 — microbiology — Posted on 2025-05-18
2237 Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner
Durand-de Cuttoli, R.; Issler, O.; Pedersen, S. M. B.; Yakubov, B.; Jahan, N.; Abid, A.; Kasparov, S.; Granizo, K.; Ahmed, S.; Russo, S. J.; Nestler, E. J.; Sweis, B. M.
10.1101/2024.05.08.592609 — neuroscience — Posted on 2025-05-18
2239 A multi-model approach defines function altering MECP2 missense variants identified in individuals with autism spectrum disorder
Chen, E.; Schmitt, J.; McIntosh, G.; Young, B.; Lian, T.; Liu, J.; Chen, K.; Liston, J. B.; MacDonald, L.; Wang, B.; Medina Giro, S.; Boehme, B.; Das, M.; Indran, S.; Chao, J.; Rogic, S.; Pavlidis, P.; Allan, D. W.; Loewen, C.
10.1101/2024.08.13.607763 — neuroscience — Posted on 2025-05-18
2240 Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from Methylated DNA Sequencing data (MeD-seq)
Hazelaar, D. M.; Boers, R. G.; Boers, J. B.; de Weerd, V.; Helmijr, J.; Jansen, M. P.; Verheul, H. M.; Verhoef, C.; Gribnau, J.; Martens, J. W.; Makrodimitris, S.; Wilting, S. M.
10.1101/2025.01.21.633371 — bioinformatics — Posted on 2025-05-17
2243 Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy
Xiang, L.; Stewart, M.; Mooney, K.; Dai, M.; Drennan, S.; Holland, S.; Quentel, A.; Sabuncu, S.; Kingston, B. R.; Dengos, I.; Bonic, K.; Goncalves, F.; Yi, X.; Ranganathan, S.; Branchaud, B. P.; Muldoon, L. L.; Barajas, R. F.; Fischer, J. M.; Yildirim, A.
10.1101/2024.02.21.580762 — bioengineering — Posted on 2025-05-18
2246 Prg4+ fibro-adipogenic progenitors in muscle are crucial for bone fracture repair
He, Q.; Lu, J.; Liang, Q.; Yao, L.; Sun, T.; Wang, H.; Duffy, M.; Jiang, X.; Lin, Y.; Lee, J.-H.; Ahn, J.; Dyment, N.; Mourkioti, F.; Boerckel, J. D.; Qin, L.
10.1101/2025.05.14.654160 — cell biology — Posted on 2025-05-17
2247 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
Tsai, Y.-T.; Frederic-Lipp, N.; Varma, R.; Seidel, O.; Laguerre, A.; Solorio-Kirpichyan, K.; Wong, A.; Brea, R. J.; McGregor, G. H.; Cordes, T.; Devaraj, N. K.; Kuerschner, L.; Neal, S. E.; Metallo, C.; Budin, I.
10.1101/2025.05.13.652513 — cell biology — Posted on 2025-05-18
2249 Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
Arzamasov, A. A.; Rodionov, D. A.; Hibberd, M. C.; Guruge, J. L.; Kent, J. D.; Kazanov, M. D.; Leyn, S. A.; Elane, M. L.; Sejane, K.; Furst, A.; Bode, L.; Barratt, M. J.; Gordon, J.; Osterman, A.
10.1101/2024.07.06.602360 — microbiology — Posted on 2025-05-17
2251 Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex
Dellal, S.; Zurita, H.; Kruglikov, I.; Valero, M.; Abad-Perez, P.; Geron, E.; Meng, J. H.; Pronneke, A.; Hanson, J. L.; Mir, E.; Ongaro, M.; Wang, X.-J.; Buzsaki, G.; Machold, R. P.; Rudy, B.
10.1101/2025.02.26.640383 — neuroscience — Posted on 2025-05-17
2252 Peripheral CGRP engages brain-wide electrical network activity of migraine
Johnson, M. S.; Eberle, M.; Hultman, I.; Zhang, X.; Filali, Y.; Hing, B.; Matkovich, M.; Jimenez, A.; Adegboyo, A.; Velamuri, R.; Miller, J.; Chan, K.-S.; Srivastava, S.; Hultman, R.
10.1101/2024.11.14.622885 — neuroscience — Posted on 2025-05-17
2255 Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains
LeBlanc, C. J.; Stefani, J.; Soriano, M.; Lam, A.; Zintel, M. A.; Kotha, S. R.; Chase, E.; Pimentel-Solorio, G.; Vunnum, A.; Flug, K. L.; Fultineer, A. T.; Hummel, N.; Staller, M. V.
10.1101/2024.12.03.626510 — systems biology — Posted on 2025-05-17
2256 Loss of PIF7 attenuates shade and elevated temperature responses throughout the lifecycle in Pennycress
Jawahir, V.; Griffiths, M.; Adam, S.; Borphukan, B.; Sanguinet, K. A.; Phippen, W.; Wesley, T.; Heller, N.; Nusinow, D. A.
10.1101/2025.03.17.643809 — plant biology — Posted on 2025-05-17
2257 Alectinib Polypharmacology Enhances Response to Spliceosome Disruption
Ma, Y.; Poon, E.; Jin, C.; Martins da Costa, B.; Xu, Y.; Quazi, S.; Zourdoumis, N.; Wickremesinghe, C.; Chesler, L.; Keun, H. C.; Nijhuis, A.
10.1101/2025.03.28.644532 — cancer biology — Posted on 2025-05-17
2259 A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain
Liccione, M. F.; Scobey, T.; Froggatt, H. M.; Pajon, C.; Yount, B. L.; Yin, Q.; Spence, T. N.; Walter, E. B.; Saunders, K. O.; Edwards, R. J.; Baric, R. S.; Haynes, B. F.; Cain, D. W.; Sheahan, T. P.; Wrapp, D.
10.1101/2025.05.14.654097 — immunology — Posted on 2025-05-17
2260 Intraepithelial lymphocytes exhibit selective immunity to intestinal pathogens
Chawla, A. S.; James, O. J.; Bhattacharya, P.; Dikovskaya, D.; Hodge, S.; Robinson, L.; Vandereyken, M.; McSorley, H. J.; Pawlowic, M. C.; Swamy, M.
10.1101/2025.05.14.654011 — immunology — Posted on 2025-05-17
2261 Targeted Irradiation and STAT3 Inhibition Reprogram the AML Microenvironment and Extend Survival: Toward Translational Immunoradiotherapy
Sargur Madabushi, S.; Brooks, J.; Zuro, D.; Yu-Lin, S.; Kaniowski, D.; Ghimire, H.; Eun Lim, J.; Abdelhamid, A. M. H.; Ya-Huei, K.; Marcucci, G.; Wong, J.; Al Malki, M.; Stein, A.; Kortylewski, M.; Hui, S.
10.1101/2025.05.14.653587 — immunology — Posted on 2025-05-17
2262 Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewing intestinal inflammation
Yamashita, Y.; Kosako, H.; Kato, T.; Okamura, T.; Tane, M.; Tabata, S.; Iwabuchi, S.; Nakashima, K.; Tanaka, K.; Shiraishi, K.; Uchihara, Y.; Sasaki, I.; Okuzaki, D.; Shibata, A.; Mizushima, T.; Hemmi, H.; Kanazawa, N.; Kodama, S.; Ohshima, K.; Hashimoto, S.; Fujitani, Y.; Sonoki, T.; Tamura, S.; Kaisho, T.
10.1101/2025.05.14.654009 — immunology — Posted on 2025-05-17
2264 CoVET: Cryo-Electron Tomography guided by optical electrophysiology
Jung, M.; Ko, G.; Lim, D.; Kim, S.; Kim, S.; Kim, Y.-j.; Choi, M.; Roh, S.-H.
10.1101/2025.05.14.653951 — biophysics — Posted on 2025-05-17
2266 A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis
Dsouza, S.; Tersteeg, S.; Badmalia, M. D.; Chen, A.; Heck, M. S.; van Marle, G.; Corcoran, J. A.; Coffin, C. S.; Patel, T. R.
10.1101/2025.05.14.654041 — biophysics — Posted on 2025-05-17
2270 Chemical inhibition of asexual development leads to increased ultimate tensile strength in mycelial material.
Gray, K.; Edwards, H.; Doan, A. G.; Huso, W.; Lee, J.; Folmer, E.; Lawrence, O.; Marten, M. R.; Harris, S. D.
10.1101/2025.05.14.653826 — bioengineering — Posted on 2025-05-17
2272 Comprehensive degron mapping in human transcription factors
Larsen, F. B.; Voutsinos, V.; Jonsson, N.; Johansson, K. E.; Ethelberg, F. D.; Lindorff-Larsen, K.; Hartmann-Petersen, R.
10.1101/2025.05.16.654404 — biochemistry — Posted on 2025-05-17
2273 Structural evidence for metal ion catalysis in the ribosome
Hingey, J. M.; Rudolfs, B.; Haack, D. B.; Murphy, F. V.; Joseph, S.; Toor, N.
10.1101/2025.05.16.654626 — biochemistry — Posted on 2025-05-17
2274 End-product inhibition of the LRRK2-counteracting PPM1H phosphatase
Adhikari, A.; Tripathi, A.; Chiang, C. Y.; Sherpa, P. L.; Pfeffer, S. R.
10.1101/2025.05.16.654599 — biochemistry — Posted on 2025-05-17
2275 Genetic Code Expansion and Enzymatic Modifications as Accessible Methods for Studying Site-Specific Post-Translational Modifications of Alpha-Synuclein and Tau
Saleh, I. G.; Shimogawa, M.; Ramirez, J.; Abakah, B.; Venkatesh, Y.; James, H. P.; Li, M.-H.; Louie, S.; Lougee, M. G.; Chia, W.-K.; Cooley, R. B.; Mehl, R.; Baumgart, T.; Mach, R.; Eliezer, D.; Rhoades, E.; Petersson, E. J.
10.1101/2025.05.16.654576 — biochemistry — Posted on 2025-05-17
2276 Heterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment
Bulldan, A.; Zheng, M.; Meyners, C.; Purder, P.; Krieger, J.; Dreizler, J. K.; Geiger, T. M.; Repity, M.; Lein, M. H.; Lokken, I. Q.; Tewes, N.; Schwalm, M. P.; Schlesiger, S.; Moniot, S.; Knapp, S.; Hartung, I.; Holien, T.; Loewer, A.; Hausch, F.
10.1101/2025.05.16.654562 — biochemistry — Posted on 2025-05-17
2280 LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling
Sharma, M.; Aakula, A.; Denisova, O.; Ceccacci, E.; Hayatigolkhatmi, K.; Caroli, J.; Natkin, R.; Laisne, M.-C.; Huhtaniemi, R.; Ghimire, S.; Merilahti, J.; Noberini, R.; Kamila, J.; Kauko, O.; Mattevi, A.; Bonaldi, T.; Jacquemet, G.; Nykter, M.; Minucci, S.; Westermarck, J.
10.1101/2025.05.14.653937 — genomics — Posted on 2025-05-17
2281 Genome reorganization and its functional impact during breast cancer progression
Reed, K. S. M.; Fritz, A.; Greenyer, H.; Heselmeyer-Haddad, K.; Frietze, S.; Stein, J.; Stein, G.; Misteli, T.
10.1101/2025.05.14.654144 — genomics — Posted on 2025-05-17
2282 Cell modeling and rescue of a novel non-coding genetic cause of Glycogen Storage Disease IX
Iyengar, A. K.; Zou, X.; Dai, J.; Francis, R. A.; Safi, A.; Patterson, K.; Koch, R. L.; Clarke, S.; Beaman, M. M.; Chong, J. X.; Bamshad, M. J.; Majoros, W. H.; Rehder, R. C.; Bali, D. S.; Allen, A. S.; Crawford, G. E.; Kishnani, P. S.; Reddy, T. E.
10.1101/2025.05.14.654043 — genetics — Posted on 2025-05-17
2286 When is microbial cross-feeding evolutionarily stable?
Lopez, J. A.; Liu, B.; Li, Z.; Donia, M. S.; Wingreen, N. S.
10.1101/2025.05.16.654511 — microbiology — Posted on 2025-05-17
2287 Modulating gene expression and protein secretion in the bacterial predator Bdellovibrio bacteriovorus
Mihajlovic, L.; Hofacker, L. M.; Lindner, F.; Jayakumar, P.; Diepold, A.; Huwiler, S. G.
10.1101/2025.05.17.654431 — microbiology — Posted on 2025-05-17
2288 Comparative Analysis of Indole Derivative Production Among Clinical Isolates of Fusobacterium nucleatum
Scano, C. J.; Choudhury, A.; Greathouse, L.; Rojo, M.; Lavado, R.; Zaharas, G.; Hawkins, J.
10.1101/2025.05.16.654558 — microbiology — Posted on 2025-05-17
2291 Mice discriminate odour source distance via sub-sniff temporal features of odour plumes
Marin, A. C.; Harris, J. J.; Dasgupta, D.; Erskine, A.; Warner, T. P. A.; Schaefer, A. T.; Ackels, T.
10.1101/2025.05.14.653752 — neuroscience — Posted on 2025-05-17
2292 Preventing light-induced toxicity in a new mouse model of rhodopsin sector retinitis pigmentosa
Guarascio, R.; Ziaka, K.; Hau, K.; Piccolo, D.; Nieuwenhuis, S. E.; Bakoulina, A.; Asfahani, R.; Aguila, M.; Athanasiou, D.; Svara, D. S.; Li, Y.; Chen, R.; Cheetham, M. E.
10.1101/2025.05.14.653774 — neuroscience — Posted on 2025-05-17
2293 Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia
Frankhouser, D. E.; Zhao, D.; Fu, Y.-H.; Dey, A.; Chen, Z.; Irizarry, J.; Rangel Ambriz, J.; Branciamore, S.; O'Meally, D.; Ghoda, L.; Trent, J.; Forman, S.; MacLean, A. L.; Kuo, Y.-H.; Zhang, B.; Rockne, R. C.; Marcucci, G.
10.1101/2025.05.14.653262 — systems biology — Posted on 2025-05-17
2294 Sequestration-Based Neural Networks That Operate Out of Equilibrium
Nakamura, E.; Britto Bisso, F.; Gispert, I.; Moghimianavval, H.; Okuda, S.; Przybyszewska-Podstawka, A.; Chisholm, S.; Hemanth Kumar, V. S.; Perez Medina, V.; Wu, M.-R.; Cuba Samaniego, C.
10.1101/2025.05.16.654484 — synthetic biology — Posted on 2025-05-17
2295 Computational design of dynamic biosensors for emerging synthetic opioids
Leonard, A. C.; Lenert-Mondou, C.; Chayer, R.; Swift, S.; Baumer, Z. T.; Delaney, R.; Friedman, A. J.; Robertson, N.; Seder, N.; Wells, J. T.; Whitmore, L.; Cutler, S.; Shirts, M. R.; Wheeldon, I.; Whitehead, T. A.
10.1101/2025.05.15.654300 — biochemistry — Posted on 2025-05-17
2296 Entry Steps in the Biosynthetic Pathway to DiterpenoidAlkaloids in Delphinium grandiflorum and Aconitum plicatum
Miller, G. P.; Mutabdzija-Nedelcheva, L.; Andersen, T.; Pascoe, I.; Van Winkle, K.; Pluskal, T.; Hamberger, B.
10.1101/2025.05.15.654307 — biochemistry — Posted on 2025-05-17
2297 SyntheMol-RL: a flexible reinforcement learning framework for designing novel and synthesizable antibiotics
Swanson, K.; Liu, G.; Catacutan, D. B.; McLellan, S.; Arnold, A.; Tu, M. M.; Brown, E. D.; Zou, J.; Stokes, J.
10.1101/2025.05.17.654017 — biochemistry — Posted on 2025-05-17
2303 A Deep Learning approach for time-consistent cell cycle phase prediction from microscopy data
Bonte, T.; Pourcelot, O.; Safieddine, A.; Slimani, F.; Mueller, F.; Weil, D.; Bertrand, E.; Walter, T.
10.1101/2025.05.16.654306 — bioinformatics — Posted on 2025-05-17
2305 Chromosomal fusions and subsequent rearrangements shaped octopus genomes
Yoshida, M.-a.; Toth, E.; Kon-Nanjo, K.; Kon, T.; Hirota, K.; Toyoda, A.; Toh, H.; Miyazawa, H.; Terauchi, M.; Noguchi, H.; Setiamarga, D. H.; Simakov, O.
10.1101/2025.05.16.652989 — genomics — Posted on 2025-05-17
2307 A Conserved Domain of Cfap298 Governs Left-Right Symmetry Breaking in Vertebrates
Cortez, M.; Young, C. B.; Little, K. A.; Grimes, D. T.; Devenport, D.; Burdine, R. D.
10.1101/2025.05.16.654593 — developmental biology — Posted on 2025-05-17
2309 Enhancing Biomedical Optical Volumetric Imaging via Self-Supervised Orthogonal Learning
Gu, Y.; Wang, Y.; Xuan, A.; Wang, J.; Wang, L.; Zhang, L.; Li, X.; Wu, Y.; Zhang, J.; Lu, Z.; Dong, B.
10.1101/2025.05.16.654259 — neuroscience — Posted on 2025-05-17
2310 Improving proteomic dynamic range with Multiple Accumulation Precursor Mass Spectrometry (MAP-MS)
Phlairaharn, T.; Shannon, A. E.; Zeng, X.; Truong, D.-J. J.; Schoof, E. M.; Ye, Z.; Searle, B. C.
10.1101/2025.05.14.653938 — biochemistry — Posted on 2025-05-17
2311 Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish
Balciunas, D.; Kalvaityte-Repecke, M.; Gabrilaviciute, S.; Kvederaviciute, K.; Bakunaite, E.; Burg, L.; Poss, K. D.
10.1101/2025.05.15.654216 — developmental biology — Posted on 2025-05-17
2313 Selective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States
Wang, D.; Wang, X.; Wang, S.; Shi, K.-X.; Malki, S.; Chan, Y.; Feng, J.; Tang, J.; Chen, X.; McKim, D.; Zhang, C.; Hu, G.; Ying, Q.-L.
10.1101/2025.05.16.653860 — cell biology — Posted on 2025-05-17
2316 STARTER : A Stand-Alone Reconfigurable and TranslationalOoC Platorm based on Modularity and Open Design Principles
Paul, A.; Safai, E. R.; de Heus, L.; Vollertsen, A. R.; Weijgertse, K.; de Wagenaar, B.; Amirabadi, H. E.; van de Steeg, E.; Odijk, M.; van der Meer, A.; Loessberg-Zahl, J.
10.1101/2025.05.13.653800 — bioengineering — Posted on 2025-05-17
2320 The insidious degeneration of white matter and cognitive decline in Fabry disease
Johnson, J. W.; Baradaran, H.; Morgan, J.; Odeen, H.; Friel, E.; Bailey, C.; Zielinski, B. A.; Underhill, H. R.
10.1101/2025.05.14.654139 — genetics — Posted on 2025-05-17
2329 Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance
Amouyal, C.; Chen, S. P.; Denom, J.; Raho, I.; Kassis, N.; Diedisheim, M.; Mifsud, F.; Lallement, J.; Georgiadou, E.; Ibberson, M.; Croyal, M.; Jiang, X.-C.; CRUCIANI-GUGLIELMACCI, C.; Le Stunff, H.; Rutter, G. A.; Magnan, C.
10.1101/2025.05.14.653935 — physiology — Posted on 2025-05-17
2330 Pervasive homeobox gene function in the male-specific nervous system of Caenorhabditis elegans
Fernandez, R. W.; Digirolamo, A. J.; Valperga, G.; Aguilar, G. R.; Molina-Garcia, L.; Kersh, R. M.; Wang, C.; Pe, K.; Ramadan, Y. H.; Loer, C.; Barrios, A.; Hobert, O.
10.1101/2025.05.13.653874 — neuroscience — Posted on 2025-05-17
2331 sKL/mKL Transcript Ratio and Protein Localization Define a Species- and Region-Specific Klotho Signature in the CNS and AD Progression
Blanch, R.; Esandi, J.; Guerrero-Yagüe, R.; Del Rey, J.; Roig-Soriano, J.; Lleo, A.; Carro, E.; Mestre-Frances, N.; Devau, G.; Ferrer, I.; Meseguer, A.; Lanciego, J. L.; Almolda, B.; Bosch, A.; Chillon, M.
10.1101/2025.05.13.653838 — neuroscience — Posted on 2025-05-17
2336 Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury
Sharma, B.; Rehman, H.; Lu, X.; Figueiredo, V. C.; Van Remmen, H.; Kuang, S.; Brooks, S. V.; Davis, C.; Maddipati, K. R.; Markworth, J. F.
10.1101/2025.05.13.653766 — developmental biology — Posted on 2025-05-17
2338 Macrophage migration inhibitory factor is a potential therapeutic target for cisplatin induced peripheral neuropathy in breast cancer
El-Baroudy, H.; Delgadillo, X. M.; Bamania, N.; Sivakumar, B.; Dwivedi, S.; Chowdhury, B.; Joseph, N.; Pathak, S.; Mizkus, S.; Ahmed, S.; Krishnan, A.
10.1101/2025.05.13.653890 — neuroscience — Posted on 2025-05-17
2339 Dibutyryl cyclic AMP downregulates tenascin-C in neurons and astrocytes and reduces AAV-mediated gene expression in DRG neurons
Stepankova, K.; Cimpean, A.; Smejkalova, B.; Holota, R.; Bachanova, L.; Cerny, J.; Sprincl, V.; Marekova, D.; van den Herik, J.; de Winter, F.; Jendelova, P.; Urdzikova, L. M.
10.1101/2025.05.13.653846 — neuroscience — Posted on 2025-05-17
2342 Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice
Bruner, K. R.; Byington, I. R.; Marx, T. J.; Vasileva, A.; Fletcher, T.; Ghimire, S.; Zappia, I. J.; Shaju, Y.; Zeng, J.; Wachsmuth, H. R.; Carlyon, T.; Besselsen, D. G.; Drucker, D. J.; Duca, F. A.; Stern, J. H.
10.1101/2025.05.13.653849 — physiology — Posted on 2025-05-17
2345 Translation Efficiency Impacts Phage Lysis Timing and Its Precision in Single Cells
Kannoly, S.; Singh, K.; Juman, N.; Islam, Z. M.; Caballero Quiroga, I.; Singh, A.; Dennehy, J. J.
10.1101/2025.05.14.654169 — microbiology — Posted on 2025-05-17
2346 Bridging Gaps in Soil Ecology: Metagenomic Insights into Microbial Diversity and Functionality Across Brazil's Biomes.
Tacca, L. M. A.; Lima, R. N.; Pascoal, P. V.; de Oliveira, M. A.; de Azevedo, C. A. X.; Bambil, D.; Mizotte, P.; Rosinha, G. M. S.; Bittencourt, D. M. d. C. B. M. d. C.; Signor, D.; de Moura, M. S. B.; Trindade, J. P. P.; Volk, L. B. d. S.; Fernandes, F. A.; Lopes, R.; Simoes-Araujo, J. L.; Freire, M.; Rech, E.
10.1101/2025.05.16.654316 — microbiology — Posted on 2025-05-17
2347 Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy
Tang, E.; Hu, Y.; Cao, G.; Asby, N. W.; Nguyen, D.-T.; Aboelella, N. S.; Ruiz, H.; Zhao, Y.; Xie, L.; Chen, X.; Bishop, M. R.; Riedell, P. A.; LaBelle, J. L.; Kline, J. P.; Huang, J.
10.1101/2025.05.13.653878 — immunology — Posted on 2025-05-17
2348 See-through science: Danionella cerebrum as a model for neuroregeneration
Misyuk, M. K.; Austin, J. L.; Walechka, N. R.; Peterka, J. A.; Veldman, M. B.; Lam, P.-Y.
10.1101/2025.05.13.653880 — neuroscience — Posted on 2025-05-17
2349 Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy
Kinch, C. D.; Kesler, M.; Dogra, D. D.; Morin, K.; Ibhazehiebo, K.; Noschang, C. G.; Rho, J. M.; Kurrasch, D.
10.1101/2025.05.13.653835 — neuroscience — Posted on 2025-05-17
2351 Direct interoceptive input to the insular cortex shapes learned feeding behavior
Zhao, Z.; Xu, B.; Anthony, S.; Subramanian, S.; Granger, B.; Von-Walter, C.; Mizrachi, E.; Kidd, M.; Srigiriraju, A.; McKie, I.; Li, Z.; Bolton, M. M.; Berto, S.; Stern, S. A.
10.1101/2025.05.13.653896 — neuroscience — Posted on 2025-05-17
2352 Visual Field Inhomogeneities Shape Visual Working Memory
Papiernik-Kłodzinska, J.; Del Pin, S. H.; Wierzchon, M.; Carrasco, M.; Rutiku, R.
10.1101/2025.05.13.653695 — neuroscience — Posted on 2025-05-17
2353 Fast barcode calling based on k-mer distances
Uphoff, R. C.; Schueler, S.; Grosse, I.; Mueller-Hannemann, M.
10.1101/2025.05.12.653416 — bioinformatics — Posted on 2025-05-17
2355 Five new Caenorhabditis species from Indonesia provide exceptions to Haldane's rule and partial fertility of interspecific hybrids
Devi, M. P.; Haryoso, E.; Rais, E. I.; Karuniawan, A.; Yahya, M. Q.; Richaud, A.; Wang, J.; Rockman, M. V.; Tarno, H.; Felix, M.-A.
10.1101/2025.05.14.653126 — genetics — Posted on 2025-05-17
2357 Elephants inhabiting two forested sites in western Uganda exhibit contrasting patterns of species identity, density, and history of hybridization
Goodfellow, C. K.; Chusyd, D. E.; Bird, S. R.; Babaasa, D.; Chapman, C. A.; Hickey, J. R.; Johnson, M. B.; Kayijamahe, C.; Mutegeki, R.; Omeja, P. A.; Tumwesigye, C.; Uzabaho, E.; Wasser, S. K.; Wasserman, M. D.; Wells, C. P.; Ting, N.
10.1101/2025.05.13.653790 — ecology — Posted on 2025-05-17
2358 F-53B damages cell viability leading to impaired root development in Arabidopsis
Zhao, J.; Pan, W.; Chen, Y.; Cui, X.; Fu, H.; Luo, Y.; Chen, Z.; Huang, N.; Hu, Y.; Qin, Y.; Yu, G.; Ren, Z.; Wang, W.; Lei, X.; Liu, B.
10.1101/2025.05.13.653422 — developmental biology — Posted on 2025-05-17
2359 Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors
Bekere, I.; Rob, S.; Lübbe, J.; Kulnik, S.; Berneking, L.; Huang, J.; Schnapp, M.; Diercks, B.-P.; Carsten, A.; Ruckdeschel, K.; Aepfelbacher, M.
10.1101/2025.05.12.653505 — cell biology — Posted on 2025-05-17
2360 Insights from aquaporin structures into drug-resistant sleeping sickness
Matusevicius, M.; Corey, R. A.; Gragera, M.; Yamashita, K.; Sprenger, T.; Ungogo, M.; Blaza, J. N.; Castro-Hartmann, P.; Chirgadze, D. Y.; Chaitanya Vedithi, S.; Afanasyev, P.; Melero, R.; Warshamanage, R.; Gusach, A.; Carazo, J.-M.; Carrington, M.; Blundell, T.; Murshudov, G. N.; Stansfeld, P. J.; Sansom, M. S.; De Koning, H. P.; Tate, C. G.; Weyand, S.
10.1101/2025.05.15.654314 — molecular biology — Posted on 2025-05-17
2361 PqsE is conserved and functionally relevant in Pseudomonas aeruginosa
Trottier, M.; Groleau, M.-C.; Gauthier, J.; Vincent, A. T.; Levesque, R. C.; Deziel, E.
10.1101/2025.05.16.654539 — microbiology — Posted on 2025-05-17
2362 First report of Photobacterium damselae subspecies damselae in Razorbill (Alca torda)
Minichino, A.; Lucibelli, F.; Guardia, T.; Balestrieri, R.; Aceto, S.; Vaccaro, E.; Dipineto, L.; Sapio, M.; Santaniello, A.; De Luca Bossa, L. M.; D Alessio, N.; Fioretti, A.; Borrelli, L.
10.1101/2025.05.15.654261 — microbiology — Posted on 2025-05-17
2363 Bi-directional relationship between the biofilm of Porphyromonas gingivalis and the amyloid-beta peptide.
Dumoulin, D.; Ghrayeb, M.; Cote, S.; Garneau, D.; Chai, L.; Frost, E.; Fülöp, T.; Beauregard, P. B.
10.1101/2025.05.16.654480 — microbiology — Posted on 2025-05-17
2364 Wolbachia uses ankyrin repeats to target specific fly proteins
Hamilton, W. C.; Massey, J.; Hardy, E.; Lopez-Madrigal, S.; Phelps, M.; Martin, M.; Newton, I. L. G.
10.1101/2025.05.15.654400 — microbiology — Posted on 2025-05-17
2367 AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts
Chaigne, S.; Hof, T.; Mimoun, K.; El Ghebouli, A.; Charron, S.; Brette, F.; Choveau, F.; Pasdois, P.; Rucker-Martin, C.; Benoist, D.; Guinamard, R.; Haissaguerre, M.; Walton, R.; Bernus, O.
10.1101/2025.05.13.653917 — physiology — Posted on 2025-05-17
2368 Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells
Braband, K. L.; Kaufmann, T.; Beumer, N.; Simon, M.; Helbich, S. S.; Mihoc, D. M.; Voss, M. M.; Nedwed, A. S.; Bauer, K.; Mallm, J.-P.; Ziesmann, T.; Distler, U.; Tenzer, S.; Eckert, C.; Volkmar, M.; Weichenhan, D.; Baehr, M.; Plass, C.; Linke, M.; Diederich, S.; Klein, M.; Bopp, T.; Schild, H.; Henkel, A.; Filippi, E.; Marini, F.; Brors, B.; Gaida, M. M.; Delacher, M.
10.1101/2025.05.14.653926 — immunology — Posted on 2025-05-17
2369 Developmental factors drive the compartmentalised and discontinuous maturation of the small intestinal epithelium during the early postnatal period
Schöneich, J.; Dupont, A.; Schlösser, S.; Schmitz, M. A.; Richter, I.; Gubbi, N. M. K. P.; Cheng, M.; Maie, T.; Jäverfelt, S.; Imdahl, F.; Toussaint, C.; Saliba, A.-E.; Kuppe, C.; Pelaseyed, T.; Costa, I. G.; Hornef, M. W.
10.1101/2025.05.15.654215 — immunology — Posted on 2025-05-17
2372 Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids
Ryu, S.; Inman, J.; Hong, H.; Jovanovic, V. M.; Gedik, Y.; Jethmalani, Y.; Hur, I.; Voss, T.; Lack, J.; Collins, J.; Ormanoglu, P.; Simeonov, A.; Tristan, C. A.; Singe"c", I.
10.1101/2025.05.16.654315 — developmental biology — Posted on 2025-05-16
2374 Basolateral amygdala dopamine transmits a nonassociative emotional salience signal
Brickner, M. A.; Szot, W. E.; Wolff, A. R.; Thomas, M. J.; Saunders, B. T.
10.1101/2025.05.15.654323 — neuroscience — Posted on 2025-05-16
2376 Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh Syndrome mice
Biswas, S. R.; Tomsick, P. L.; Kelly, C.; Lester, B. A.; Milner, J. P.; Henry, S. N.; Soto, Y.; Brindley, S.; DeFoor, N.; Morton, P. D.; Pickrell, A. M.
10.1101/2025.05.16.654318 — neuroscience — Posted on 2025-05-16
2377 Multimodal cortical connectome in the default mode network across the adult lifespan
Wang, S.; Liu, X.; He, J.; chang, x.; yu, q.; Wan, B.; Liu, Z.; Mi, W.-f.; Shi, L.
10.1101/2025.05.16.654309 — neuroscience — Posted on 2025-05-16
2379 Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis
Zhu, X.; John, A. J.; Wang, L.; Kim, S.; Ding, E.; Saleh, A.; Marin-Goni, I.; Jomaa, A.; Gao, H.; Wai, C. M.; Moon, I.; Coombes, B. J.; Kerr, T. M.; Suto, N.; Wang, L.; Frye, M. A.; Biernacka, J. M.; Karpyak, V. M.; Li, H.; Weinshilboum, R. M.; Liu, D.
10.1101/2025.05.15.654319 — genomics — Posted on 2025-05-16
2380 NUSAP1 regulates mitotic processes via KIF2C interaction and AURKA phosphorylation in primary microcephaly
Ren, D.; Li, K.; Liu, C.; Bi, Y.; Liu, L.; Ji, L.; Yang, K.; Luo, Y.; Luo, L.; Yan, Y.; Li, Y.; Yang, F.; Wang, H.; He, G.; Mao, X.
10.1101/2025.05.16.654427 — genetics — Posted on 2025-05-16
2381 Comparison of oral and gut microbiome highlights role of oral bacteria in systemic inflammation in HIV
Fulcher, J. A.; Newman, K.; Pham, B.; Li, F.; Cho, G. D.; Elliott, J.; Tobin, N. H.; Shoptaw, S.; Gorbach, P. M.; Aldrovandi, G. M.
10.1101/2025.05.16.654362 — microbiology — Posted on 2025-05-16
2383 Cell shapes decode molecular phenotypes in image-basedspatial proteomics
Le, T.; Leineweber, W. D.; Viana, M. P.; Cesnik, A.; Hansen, J. N.; Ouyang, W.; Rafelski, S. M.; Lundberg, E.
10.1101/2025.05.13.653868 — bioengineering — Posted on 2025-05-16
2384 The Critical Role of the C-terminal Lobe of Calmodulin in Activating Eukaryotic Elongation Factor 2 Kinase
Long, K. J.; Browning, L. S.; Piserchio, A.; Isiorho, E. A.; Gadallah, M.; Douangvilay, J.; Wang, E. Y.; Kalugin, J. K.; Brodbelt, J. S.; Ghose, R.; Dalby, K. N.
10.1101/2025.05.13.653565 — biochemistry — Posted on 2025-05-16
2385 Synergistic Action of Commercial Lipase, Lipoxygenases and Proteinase towards PLA Depolymerization
Salini, A.; Gonnelli, P.; Padoan, C.; Helali, Y.; Waeytens, J.; Fusco, S.; Cannella, D.
10.1101/2025.05.13.653912 — biochemistry — Posted on 2025-05-16
2386 Sequence based prediction of cell type specific microRNA binding and mRNA degradation for therapeutic discovery
Kanuparthi, B.; Pour, S. E.; Findlay, S. D.; Wagih, O.; Gutierrez, J. M.; Gao, R.; Wintersinger, J.; Lin, J.; Gabra, M.; Bohn, E.; Lau, T.; Cole, C. B.; Jung, A.; Celaj, A.; Soares, F.; Gray, R.; Vaz, B.; Delfosse, K.; Lodaya, V.; Bhargava, S.; Ly, D.; Yusuf, F.; Kron, K.; Hoffman, G.; Gandhi, S.; Frey, B. J.
10.1101/2025.05.15.654105 — genomics — Posted on 2025-05-16
2387 Biophysical Modeling Uncovers Transcription Factor and Nucleosome Binding on Single DNA Molecules
Dalakishvili, L.; Managori, H.; Bardet, A.; Slaninova, V.; Bertrand, E.; Molina, N.
10.1101/2025.05.13.653852 — genomics — Posted on 2025-05-16
2390 PhylloTraits 1.0: Unveiling the diversity of functional traits
Villalobos, F.; Saldana-Vazquez, R. A.; Azofeifa-Romero, Y.; Pineda-Lizano, W.; Sanchez, M. S.; Ayala-Berdon, J.; Carballo-Morales, J. D.; Castano, J. H.; Hernandez-Montero, J. R.; Herrera-Alsina, L.
10.1101/2025.05.13.653771 — ecology — Posted on 2025-05-16
2391 Bile acids target an exposed cavity in the glucocorticoid receptor modulating receptor self-assembly, chromatin binding and transcriptional activity
Jimenez-Panizo, A.; Johnson, T. A.; Wagh, K.; Alegre-Marti, A.; Montoya-Novoa, I.; Lafuente, A. L.; Eckhard, U.; Rodriguez-Lumbreras, L. A.; Hoang, L.; Stortz, M.; Abella, M.; Goldstein, I.; Valledor-Fernandez, A.; Varticovski, L.; Arias, I.; Presman, D. M.; Stavreva, D. A.; Fernandez-Recio, J.; Fuentes-Prior, P.; Hager, G. L.; Estebanez-Perpina, E.
10.1101/2025.05.13.653693 — molecular biology — Posted on 2025-05-16
2393 Model-independent reorganization of translation in TDP-43 Amyotrophic Lateral Sclerosis
Lauria, F.; Maniscalco, F.; Perrucci, C.; Marchioretto, M.; Bruno, I.; Tome, G.; Cella, F.; Busarello, E.; Sevegnani, M.; Lunelli, L.; Donini, L.; Tebaldi, T.; D Antoni, M.; Pollini, D.; Peroni, D.; Pisciottani, A.; Croci, L.; Badaloni, A.; Arnese, R.; Provenzani, A.; Quattrone, A.; Consalez, G. G.; Clamer, M.; Siciliano, V.; Basso, M.; Viero, G.
10.1101/2025.05.15.654227 — molecular biology — Posted on 2025-05-16
2395 The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes
Odai, R.; Leemann, M.; Al-Murad, T.; Abdullah, M.; Shyrokova, L.; Tenson, T.; Hauryliuk, V.; Durairaj, J.; Pereira, J.; Atkinson, G. C.
10.1101/2025.05.14.653371 — molecular biology — Posted on 2025-05-16
2396 Efficient CRISPR-Cas9-mediated genome editing of the cane toad (Rhinella marina)
Clark, M.; Funk, A.; Paporakis, A.; Brown, G. P.; Beach, S. J.; Tay, A.; Deering, S.; Cooper, C.; Tizard, M.; Jolly, C. J.; Ward-Fear, G.; Waddle, A. W.; Shine, R.; Maselko, M.
10.1101/2025.05.15.654396 — synthetic biology — Posted on 2025-05-16
2397 A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation
Palou, R.; van der Sloot, A. M.; Fiebig, A. A.; Zangara, M. T.; Sangwan, N.; Sanchez-Osuna, M.; Ilyas, B.; Zubyk, H.; Cook, M.; Wright, G. D.; Coombes, B. K.; Tyers, M.
10.1101/2025.05.15.652971 — synthetic biology — Posted on 2025-05-16
2398 Experimental Evaluation of AI-Driven Protein Design Risks Using Safe Biological Proxies
Ikonomova, S. P.; Wittmann, B. J.; Piorino, F.; Ross, D. J.; Schaffter, S. W.; Vasilyeva, O. B.; Horvitz, E.; Diggans, J.; Strychalski, E. A.; Lin-Gibson, S.; Taghon, G. J.
10.1101/2025.05.15.654077 — synthetic biology — Posted on 2025-05-16
2401 Fibronectin Composition and Transglutaminase 2 Cross-linking Cooperatively Regulate Ovarian Cancer Cell Adhesion in ECM-Mimetic Constructs
Yang, N.; Abbaspour, A.; Considine, J. M.; McGregor, S. M.; Brooks, E. G.; Naba, A.; Masters, K. S.; Kreeger, P. K.
10.1101/2025.05.13.653765 — bioengineering — Posted on 2025-05-16
2402 Quantification of disease-associated RNA tandem repeats by nanopore sensing
Patino-Guillen, G.; Pesovic, J.; Panic, M.; Earle, M.; Ninkovic, A.; Petrusca, S.; Savic-Pavicevic, D.; Keyser, U. F.; Boskovic, F.
10.1101/2025.05.15.653973 — biochemistry — Posted on 2025-05-16
2405 Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies
Mullis, M. N.; Lefebvre, A. E. Y. T.-S.; Sivasubramanian, K.; Luo, A.; Schmid, F.; Sooknah, M.; Wright, K. M.; Raj, A.; Zavala-Solorio, J.; Zhang, C.; Riegler, J.; Gillich, A.; Ruby, J. G.
10.1101/2025.05.13.653808 — genetics — Posted on 2025-05-16
2406 Structure of YbbAP-TesA: a Type VII ABC transporter lipid-hydrolase complex
McAndrew, M. B.; Cook, J.; Gill, A.; Sahoo, K.; Thomas, C.; Stansfeld, P. J.; Crow, A.
10.1101/2025.05.16.654284 — microbiology — Posted on 2025-05-16
2407 Prolonged non-suppressible viremia sustained by a clonally expanded, genomically defective provirus with an immune-evasive HIV protein expression profile
Omondi, F. H.; Sang, Y.; Mwimanzi, F.; Cheung, P. K.; Derza, Z.; Dong, W.; Barad, E.; Anderson, K.; Mysak, V.; Lima, V. D.; Hull, M.; Brumme, C. J.; Harris, M.; Montaner, J. S. G.; Guillemi, S.; Brockman, M. A.; Brumme, Z. L.
10.1101/2025.05.16.654538 — microbiology — Posted on 2025-05-16
2409 Bioelectricity generation by Symbiodinium microadriaticum: a symbiont-forming photosynthetic dinoflagellate alga from coral reefs
Marcel, L.; Simon, J. T.; Lawrence, J. M.; Menkin, S.; Barbrook, A. C.; Nisbet, R. E. R.; Howe, C. J.; Zhang, J. Z.
10.1101/2025.05.16.654495 — microbiology — Posted on 2025-05-16
2410 Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design
He, L.; Lee, Y.-Z.; Zhang, Y.; Newby, M. L.; Janus, B. M.; Gonzalez, F. G.; Ward, G.; DesRoberts, C.; Hung, S.-H.; Giang, E.; Allen, J. D.; Kulakova, L.; Toth, E. A.; Fuerst, T.; Law, M.; Ofek, G.; Crispin, M.; Zhu, J.
10.1101/2025.05.16.654559 — microbiology — Posted on 2025-05-16
2414 PEPlife2: A Updated Repository of the Half-life of Peptides
Alam, U.; Chaudhary, K.; Kumar, N.; Tomer, R.; Patiyal, S.; Raghava, G. P. S.
10.1101/2025.05.13.653654 — bioinformatics — Posted on 2025-05-16
2415 MSH3 is a genetic modifier of somatic repeat instability in X-linked dystonia parkinsonism
MAZA, A. M.; Hincher, M.; Correia, K.; Gillis, T.; Nishiyama, A.; Penney, E. B.; Domingo, A.; Yadav, R.; Murcar, M. G.; Mercado, P.; Han, J. S.; Norenberg, E. P.; Fernandez-Cerado, C.; Legarda, G. P.; Sy, M.; Munoz, E.; Ang, M. C.; Diesta, C. C. E.; Go, C.; Sharma, N.; Bragg, D. C.; Talkowski, M. E.; MacDonald, M. E.; LEE, J.-M.; Ozelius, L. J.; Wheeler, V. C.
10.1101/2025.05.14.653432 — genetics — Posted on 2025-05-16
2419 Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress
Venkatasubramanian, R.; Darrah, M. A.; Mahoney, S. A.; Hutton, D. A.; Maurer, G. S.; Ludwig, K. R.; VanDongen, N. S.; Greenberg, N. T.; Longtine, A. G.; Brunt, V. E.; Singh, P.; Galligan, J. J.; Trujillo, M. N.; Kapahi, P.; Melov, S.; Campisi, J.; Rossman, M. J.; Seals, D. R.; Clayton, Z. S.
10.1101/2025.05.13.653823 — physiology — Posted on 2025-05-16
2420 Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity
Majcher, A.; Karsai, G.; Yusifov, E.; Schaettin, M.; Malagola, E.; Horvath, P.; Li, J.; Shamshiddinova, M.; Zhibo, G.; Dubey, R.; Peterson, T.; Rodriguez-Gallardo, S.; Kuniyoshi, S.; Harayama, T.; Hornemann, T.
10.1101/2025.05.13.653734 — biochemistry — Posted on 2025-05-16
2421 Oocyte mitochondria link maternal environment to offspring phenotype
Cooper, J.; Nguyen, K.; Gates, D.; Wolfrum, E.; Capan, C.; Lee, H.; Williams, D.; Okoye, C.; Nauta, K. M.; Sanchez-Avila, X.; Kelly, R. T.; Sheldon, R.; Wojtovich, A. P.; Burton, N. O.
10.1101/2025.05.13.653493 — genetics — Posted on 2025-05-16
2422 Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals
Etani, T.; Nakajima, S.; Honda, S.; Homma, S.; Kaneko, Y.; Kondoh, S.; Tarumi, R.; Tsugawa, S.; Moriyama, S.; Tobari, Y.; Samma, T.; Horga, G.; Cassidy, C.; Uchida, H.; Fujii, S.
10.1101/2025.05.10.653047 — neuroscience — Posted on 2025-05-16
2425 Thermal suppression of gametogenesis can explain historical collapses in larval recruitment
Okamoto, D. K.; Spindel, N.; Munstermann, M. J.; Karelitz, S.; Collicutt, B.; Gimenez, I.; Rolheiser, K.; Cronmiller, E.; Foss, M.; Mahara, N.; Swezey, D.; Ferraro, R.; Rogers-Bennett, L.; Schroeter, S.
10.1101/2023.09.28.559919 — ecology — Posted on 2025-05-16
2426 Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception
Carricarte, T.; Xie, S.; Singer, J.; Trampel, R.; Huber, L.; Weiskopf, N.; Cichy, R. M.
10.1101/2025.05.13.653501 — neuroscience — Posted on 2025-05-16
2427 Alcohol use disorder is associated with increases in frontocentral phase-amplitude coupling strength during resting state
Richard, C. D.; Porjesz, B.; Meyers, J. L.; Bingly, A.; Chorlian, D. B.; Kamarajan, C.; Pandey, G.; Kuang, W.; Pandey, A. K.; Kinreich, S.
10.1101/2025.05.13.653768 — neuroscience — Posted on 2025-05-16
2428 Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional program of liver cells.
SOUAIFAN, H.; COSTALLAT, M.; SITKIEWICZ, L.; GODEST, K.; CAMMAS, F.; MANN, C.; MUCHARDT, C.; RACHEZ, C.
10.1101/2025.02.14.638307 — molecular biology — Posted on 2025-05-16
2429 Bidirectional modulation of reward-guided decision making by dopamine
Dias Maile, A. A.; Gruendler, T. O. J.; Fischer, A. G.; Froböse, M. I.; Kurtenbach, H.; Kaiser, L. F.; Jocham, G.
10.1101/2024.03.27.586793 — neuroscience — Posted on 2025-05-16
2430 Fornix subdivisions and spatial learning: a diffusion MRI study
Hodgetts, C. J.; Postans, M.; Williams, A. N.; Graham, K. S.; Lawrence, A. D.
10.1101/2025.05.15.654313 — neuroscience — Posted on 2025-05-16
2432 Enteropancreatic neurons drive the glucoregulatory response to ingested lipid
Roberts, A. G.; Meyer, L.; Norton, M.; Phuah, P.; Martin Alonso, A.; Dowsett, G. K.; Cheng, S.; Dunsterville, C.; Liu, J.; Chung, P.-E.; Tao, Y.; Smitherman-Cairns, T.; Deutsch, A. B.; Chatterjee, A.; Lam, B. Y.; Hanyaloglu, A.; Jones, B.; Yeo, G. S. H.; Salem, V.; Murphy, K. G.
10.1101/2025.05.09.652620 — physiology — Posted on 2025-05-16
2433 Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium
Emin, M. T.; Dubuisson, A. M.; Sujin Kumar, P.; Knutsen, C.; Alvira, C. M.; Hough, R. F.
10.1101/2025.02.26.640349 — physiology — Posted on 2025-05-16
2434 Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer
Kay, J. E.; Corrigan, J. J.; Volk, L. B.; Armijo, A. L.; Nazari, I. S.; Torous, D. K.; Avlasevich, S. L.; Croy, R. G.; Wadduwage, D. N.; Dertinger, S. D.; Essigmann, J. M.; Samson, L. D.; Engelward, B. P.
10.1101/2025.05.13.653839 — cancer biology — Posted on 2025-05-16
2435 Oncogenic RAS signaling suppresses ferroptosis via transcriptional upregulation of GCH1
Lim, J. K.; Stoelting, F.; Levy, T.; Thewes, L.; Picard, D.; Tishina, S.; Zhang, H.-F.; Lewandowska, O.; Reiff, T.; Remke, M.; Braegelmann, J.; Beleggia, F.; Berndt, C.; von Karstedt, S.; Reifenberger, G.; Rotblat, B.; Leprivier, G.
10.1101/2024.01.27.577524 — cancer biology — Posted on 2025-05-16
2436 SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution
Liao, L.; Madan, E.; Palma, A.; Kim, H.; Kumar, A.; Bhoopathi, P.; Winn, R.; Trevino, J.; Fisher, P.; Brakebusch, C.; Kim, G.; Kim, J.; Gogna, R.; Won, K. J.
10.1101/2023.08.22.554277 — bioinformatics — Posted on 2025-05-16
2437 Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease
Busarello, E.; Biancon, G.; Cimignolo, I.; Lauria, F.; Ibnat, Z.; Ramirez, C.; Tome, G.; Ciuffreda, M.; Bucciarelli, G.; Pilli, A.; Marino, S. M.; Bontempi, V.; Ress, F.; Aass, K. R.; VanOudenhove, J. J.; Tiberi, L.; Mione, M.; Standal, T.; Macchi, P.; Viero, G.; Halene, S.; Tebaldi, T.
10.1101/2024.03.08.584053 — bioinformatics — Posted on 2025-05-16
2439 Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation
Seira Curto, J.; Fernandez Gallegos, M. R.; Villegas Hernandez, S.; Sanchez de Groot, N.
10.1101/2025.01.24.634659 — biochemistry — Posted on 2025-05-16
2440 Image-based DNA Sequencing Encoding for Detecting Low-Mosaicism Somatic Mobile Element Insertions
Tan, M.; Lin, Z.; Chen, Z.; Zhou, H.; Park, J.; He, Z.; Lee, E. A.; Gao, Z.; Zhu, X.
10.1101/2024.11.07.619809 — genomics — Posted on 2025-05-16
2443 Lightning-caused disturbance frequency and severity varies with topography in an Afromontane forest
Gora, E.; Ngute, A. S. K.; Batumike, R.; Cuni-Sanchez, A.; Imani, G.; Kaplin, B.; Bantlin, D.; Bitariho, R.; Zoletto, B.; Petridis, N.; Sheil, D.; Sullivan, M. J. P.
10.1101/2025.05.13.653675 — ecology — Posted on 2025-05-16
2444 eDNA sampling reveals no negative effects of beaver recolonisation on the catchment-scale distribution of migratory fish
Macarthur, J. A.; Law, A.; Willby, N.; Svobodova, D.; Griffiths, N. P.; Campbell, R.; Gaywood, M. J.; Bean, C. W.; Lawson Handley, L.; Smith, M.; Leonard, S.; Conroy, C.; Pritchard, V. L.; Hänfling, B.
10.1101/2025.05.13.653709 — ecology — Posted on 2025-05-16
2446 Oncogenic mutations disrupt lineage differentiation via epigenetic perturbations
Meng, L.; Yu, A.; Huang, H.; Meng, J.; Yoo, Y.; Schaukowitch, K. M.; Janas, J.; Knowles, D. A.
10.1101/2025.04.22.649974 — cell biology — Posted on 2025-05-16
2448 PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity
Gonzalez Nunez, M.; C. Vasconcellos, L. R.; Garrido Mesa, J.; Cardoso Maciel Costa Silva, R.; Hachani, A.; Bosquet Agudo, A.; Simeoli, R.; Medrano Gonzalez, L.; Filloux, A.; C. E. Welch, H.; Perretti, M.; Vanhaesebroeck, B.; Dombrowicz, D.; Haworth, O.; Kok, K.; Manoury, B.; Aksoy, E.
10.1101/2025.05.13.653657 — immunology — Posted on 2025-05-16
2449 Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter
Ayyildiz, N.; Mueller, K.; Hardikar, S.; Beyer, F.; Enzenbach, C.; Baber, R.; Wirkner, K.; Zachariae, S.; Girbardt, J.; Hassett, J. D.; Anwander, A.; Elze, T.; Wang, M.; Witte, A. V.; Rauscher, F. G.; Villringer, A.
10.1101/2025.05.13.653685 — neuroscience — Posted on 2025-05-16
2454 EPIGENETIC REPROGRAMMING OF CELL IDENTITY IN THE RAT PRIMARY NEURON-GLIA CULTURES INVOLVES HISTONE SEROTONYLATION
Borodinova, A. A.; Leontovich, Y. A.; Beletskiy, A. P.; Revishchin, A. V.; Pavlova, G. V.; Balaban, P. M.
10.1101/2025.05.13.653697 — neuroscience — Posted on 2025-05-16
2455 Immediate TMS-EEG responses reveal motor cortex excitability
Stango, A.; Zazio, A.; Barchiesi, G.; Bonfiglio, N. S.; Dognini, E.; Marcantoni, E.; Bortoletto, M.
10.1101/2024.08.20.608770 — neuroscience — Posted on 2025-05-16
2457 Armadillo Repeat Only Proteins Are Required for the Function of Plant CNGC Channels.
Kulich, I.; Oulehlova, D.; Vladimirtsev, D.; Zou, M.; Lileikyte, E.; Kulichova, K.; Janda, M.; Iakovenko, O.; Neubergerova, M.; Studtrucker, T.; Pleskot, R.; Dietrich, P.; Fendrych, M.; Friml, J.
10.1101/2025.01.06.631460 — plant biology — Posted on 2025-05-16
2458 Unconventional myosin VI is involved in the regulation of muscle energy metabolism
Wojton, D.; Dymkowska, D.; Matysniak, D.; Topolewska, M.; Redowicz, M. J.; Lehka, L.
10.1101/2025.05.13.653637 — physiology — Posted on 2025-05-16
2459 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer
Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Zhang, X.; Li, Y.
10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-05-16
2470 Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism
cartmell, A.; Crawford, C. J.; Tomlinson, C. W.; Gunawan, C.; Chen, Z.; Byrne, D. P.; Darby, C.; Conti, M. L.; Larson, T.; Luis, A. S. J.; Elli, S.; Yates, E. A.; Bolam, D. N.; van der Post, S.; Williams, S. J.
10.1101/2024.04.27.591440 — biochemistry — Posted on 2025-05-16
2474 ATaRVa: Analysis of Tandem Repeat Variation from Long Read Sequencing data
Sivakumar, A. K.; Sudarsanam, S.; Sharma, A.; Avvaru, A. K.; Sowpati, D. T.
10.1101/2025.05.13.653434 — genomics — Posted on 2025-05-16
2475 Natural diversity of telomere length distributions across 100 yeast strains
Garrido, C.; Kornobis, E.; Agier, N.; Ilioaia, O.; Fischer, G.; Xu, Z.
10.1101/2025.05.13.653712 — genomics — Posted on 2025-05-16
2477 Systemic bio-inequity links poverty to biodiversity and induces a conservation paradox
Waldock, C.; Nguyen, V. T. H.; Awuor Owuor, M.; Samwel Manyanza, A.; Seehausen, O.
10.1101/2025.05.13.653456 — ecology — Posted on 2025-05-16
2480 eDNA enables proof-of-origin of samples from reservoirs with rich and abundant biodiversity
REBELO, M. D. F.; CORTEZ, T.; Godinho, J. G. N.; Coelho, J.; Cavalcanti, R.; Bomfim, H.; Cunha, Y.; Dondero, F.; Amaral, D.; Americo, J. A.
10.1101/2025.05.13.653644 — ecology — Posted on 2025-05-16
2482 Intensity Modulation of Trichromatic Split Fluorescent Proteins for Live Cell Mapping
Ishii, M.; Kinjo, T.; Kondo, Y.; Terai, K.; Aoki, K.; Kuhlman, B.; Matsuda, M.
10.1101/2025.05.13.653616 — cell biology — Posted on 2025-05-16
2483 Cellular metabolic state controls mitochondrial RNA kinetics
Reardon, S. D.; Bautista, C.; Cole, S. C.; Cicero, J.; Mishanina, T. V.
10.1101/2025.05.13.653903 — molecular biology — Posted on 2025-05-16
2484 A Short 63-Nucleotide Element Promotes Efficient circRNA Translation
Biagi, M. C.; Giuliani, A.; Grandioso, A.; Di Timoteo, G.; Bozzoni, I.
10.1101/2025.05.13.653105 — molecular biology — Posted on 2025-05-16
2486 Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer
Kong, H.; Wu, X.; Yang, Q.; Sun, Q.; Yu, X.; Dai, Y.; Wu, C.; Xie, D.; Chen, L.; Ma, P.; Dai, S.; Chen, C.; Mi, P.; Feng, X.; Peng, Y.; Shi, H.; Zhang, D.; Ke, N.; Cao, D.; Zhou, Z.; Hu, B.; Wang, P.; Chen, L.; Liu, Y.-H.; Wei, Q.; Jiang, H.
10.1101/2024.07.24.604770 — immunology — Posted on 2025-05-16
2487 Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation
Dhariwala, M. O.; Carale, R. O.; DeRogatis, A. M.; Rodriguez-Valbuena, H.; Okoro, J. N.; Ekstrand, C.; Weckel, A. A.; Tran, V. M.; Habrylo, I.; Barrere-Cain, R.; Ojewumi, O. T.; Tammen, A. E.; Tsui, J.; Shaikh, S.; Yellamilli, S.; Aladhami, A. K.; Leech, J. M.; Merana, G. R.; Hiam-Galvez, K. J.; Halkias, J.; Gardner, J.; Rutishauser, R. L.; Fragiadakis, G. K.; Spitzer, M. H.; Combes, A. J.; Scharschmidt, T. C.
10.1101/2023.09.29.560039 — immunology — Posted on 2025-05-16
2489 Robust TCR production for the structural study of TCR-pMHC complexes
Oyon-Olea, L.; Dichiara-Rodriguez, M. G.; Hervas-Stubbs, S.; Erausquin, E.; Lopez-Sagaseta, J.
10.1101/2025.05.12.653033 — immunology — Posted on 2025-05-16
2490 Individual Differences in Policy Precision: Links to Suicidal Ideation and Network Dynamics
Yoon, D.; Kim, J.; Kim, D. H.; Shin, D. W.; Bong, S. H.; Kim, J.; Park, H.-j.; Jeon, H. J.; Jeong, B.
10.1101/2024.10.15.618415 — neuroscience — Posted on 2025-05-16
2491 NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia Telangiectasia
Stirparo, G. G.; Xu, X.; Thompson, T.; Page, K.; Harvey, J. R.; Cadwalladr, D.; Lawrence, J.; Burley, R. J.; Juvvanapudi, J.; Roberts, M.; Barker, D. F.; Mulligan, V.; Sherlock, C.; Lizio, M.; Christie, L.; Mudaliar, M.; Sheardown, S.; Margus, B.; Thompson, C.; Dickson, L.; Brice, N. L.; Carlton, M. B.; Powell, J. A.; Dawson, L. A.
10.1101/2025.05.13.653662 — neuroscience — Posted on 2025-05-16
2492 High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease
Saito, K.; Goulding, D. S.; Nolt, G. L.; Dimas, S. H.; Moore, L. C.; Stevens, I. O.; Anderson, S.; Snipes, A.; Macauley, S. L.; Nelson, P. T.; Johnson, L.; Morganti, J.
10.1101/2025.05.16.654329 — neuroscience — Posted on 2025-05-16
2495 Fine-tuning quantitative agronomic traits by manipulating gene copy number in rice
Nomura, C.; Kanzaki, H.; Kanzaki, E.; Shimizu, M.; Oikawa, K.; Utsushi, H.; Ito, K.; Sugimura, Y.; Terauchi, R.; Abe, A.
10.1101/2025.05.16.654416 — plant biology — Posted on 2025-05-16
2496 Arabidopsis lines with modified ascorbate concentrations reveal a link between ascorbate and auxin biosynthesis
Fenech, M.; Zulian, V.; Moya-Cuevas, J.; Arnaud, D.; Morilla, I.; Smirnoff, N.; Botella, M. A.; Stepanova, A. N.; Alonso, J. M.; Martin-Pizarro, C.; Amorim-Silva, V.
10.1101/2025.05.15.654287 — plant biology — Posted on 2025-05-16
2502 Megabase-scale human genome rearrangement with programmable bridge recombinases
Perry, N. T.; Bartie, L. J.; Katrekar, D.; Gonzalez, G. A.; Durrant, M. G.; Pai, J. J.; Fanton, A.; Hiraizumi, M.; Ricci-Tam, C.; Nishimasu, H.; Konermann, S.; Hsu, P. D.
10.1101/2025.05.14.653916 — bioengineering — Posted on 2025-05-16
2503 ERGA-BGE genome of Pinctada radiata (Leach, 1814): one of the first Lessepsian migrants
Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Genoscope Sequencing Team, ; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Istace, B.; Couloux, A.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Haggerty, L.; Martin, F.; Bortoluzzi, C.
10.1101/2025.01.17.632165 — genomics — Posted on 2025-05-16
2504 Constrained Open Chromatin Regions Reveal Functional Elements Shaping Human Traits
Tomizuka, K.; Koido, M.; Suzuki, A.; Yoshino, S.; Tanaka, N.; Ishikawa, Y.; Liu, X.; Koyama, S.; Ishigaki, K.; Murakawa, Y.; Immune transcript/enhancer consortium (ITEC), ; Yamamoto, K.; Terao, C.
10.1101/2024.10.31.621195 — genetics — Posted on 2025-05-16
2506 Epigenomic dynamics of clonal evolution reveal new regulators of leukemic growth
Bonilla, G.; Morris, A.; Kundu, S.; Ducasse, A.; Kirkpatrick, G.; Jeffries, N. E.; Chetal, K.; Yvanovich, E. E.; Milosevic, J.; Zhao, T.; Xia, J.; Barghout, R.; Scadden, D.; Mansour, M.; Kingston, R. E.; Sykes, D. B.; Mercier, F. E.; Sadreyev, R. I.
10.1101/2024.02.29.582846 — molecular biology — Posted on 2025-05-16
2507 Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy
Ribis, J. W.; Nieto-Acuna, C. A.; DiBenedetto, N.; Mehra, A.; Dong, Q.; Nagawa, I. L.; El Meouche, I.; Aldridge, B. B.; Dunlop, M. J.; Tamayo, R.; Singh, A.; Shen, A.
10.1101/2024.02.13.580212 — microbiology — Posted on 2025-05-16
2509 Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab
Kyyriainen, J.; Della Pietra, A.; Torkamani-Azar, M.; Gomez- Budia, M.; Novosolova, N.; Eronen, H.; Narvaez, O.; Paasonen, E.; Lezhneva, V.; Pelkonen, A.; Saveleva, L.; Huotarinen, A.; Belevich, I.; Jokitalo, E.; Kuopio Epilepsy Center Epilepsy Surgery Group, ; Jutila, L.; Rauramaa, T.; Immonen, A.; Leinonen, V.; Tohka, J.; Grohn, O.; Kalviainen, R.; Malm, T.; Sierra, A.
10.1101/2025.04.15.648977 — neuroscience — Posted on 2025-05-16
2510 Condenzymes: Biomolecular condensates with inherent catalytic activities
Chen, M. W.; Guo, X.; Farag, M.; Qian, N.; Song, X.; Ni, A.; Liu, V.; Yu, X.; Ma, Y.; Yang, L.; Yu, W.; King, M.; Lee, J.; Zare, R. N.; Min, W.; Pappu, R. V.; Dai, Y.
10.1101/2024.07.06.602359 — biophysics — Posted on 2025-05-16
2511 Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22
Yamaguchi, T.; Okatsu, K.; Kubota, M.; Mitsumori, A.; Yamagata, A.; Fukata, Y.; Fukata, M.; Shibata, M.; Fukai, S.
10.1101/2025.01.06.631603 — biochemistry — Posted on 2025-05-16
2513 Human receptive endometrial assembloid for deciphering the implantation window
Zhang, Y.; Zhao, R.; Yang, C.; Song, J.; Liu, P.; Li, Y.; Liu, B.; Li, T.; Yin, C.; Lu, M.; Hou, Z.; Zhang, C.; Chen, Z.-J.; Wu, K.; Zhao, H.
10.1101/2023.07.27.550771 — cell biology — Posted on 2025-05-16
2515 Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians
McCubbin, R. A.; Auwal, M. A.; Wang, S.; Zepeda, S. A.; Sasik, R.; Zeller, R. W.; Ross, K. G.; Zayas, R. M.
10.1101/2025.05.15.654132 — developmental biology — Posted on 2025-05-16
2516 The planktonic microbiome of the Great Barrier Reef
Robbins, S. J.; Dougan, K.; Terzin, M.; Zaugg, J.; Bell, S. C.; Laffy, P. W.; Engelberts, J. P.; Webster, N. S.; Hugenholtz, P.; Bourne, D. G.; Yeoh, Y. K.
10.1101/2025.05.13.653689 — genomics — Posted on 2025-05-16
2520 Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution
Aprile, D.; Leonardi, O.; Petrella, A.; Castaldi, D.; Culotta, L.; Cheroni, C.; Valente, A.; Bonfanti, M.; Vitriolo, A.; Moriano, J.; Mirabella, F.; Tintori, A.; Boeckx, C.; Testa, G.
10.1101/2025.05.14.653684 — neuroscience — Posted on 2025-05-16
2521 Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties
Tang, N.; Wilson, K.; Weldemarian, M. M.; Tian, H.; Hart, C. D.; Rammath, P.; Sivalingam, D. S.; Glazier, J.; Jiang, J.; Leong, N.; Lowe, T.; Kane, M. A.; Iwamoto, M.; Kuo, C. K.; Enomoto-Iwamoto, M.
10.1101/2025.05.13.653102 — pathology — Posted on 2025-05-16
2522 PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance
Wang, H.; Yun, Z.; Cao, Y.; Li, X.; Liu, Z.; Pai, C.-P.; Wu, C.; Yue, J.; Lin, G.; Cai, J.; Willard, B.; Yang, S.; Keri, R. A.; Schiemann, W. P.; Diehl, J. A.; Kao, H.-Y.
10.1101/2025.05.15.653365 — cancer biology — Posted on 2025-05-16
2523 Single-Cell RNA Sequencing and Inferred Protein Activity Analysis Reveal a Distinct Tumor Phenotype in Early-Onset Colorectal Cancer Patients
Cohen, D. A.; Obradovic, A.; Jovanovic, L.; Mitani, Y.; Li, T.; Lee, S.; De, D.; Bethancourt, C.-N.; Shin, A.; Dunbar, K.; Cambuli, F.; Lengner, C.; Li, N.; Rogers, C.; Ho, J.; Jakubikova, V.; Blystone, E.; Pumpalova, Y.; Dionigi, B.; Vickovic, S.; Cheng, C.-W.; Gabre, J.
10.1101/2025.05.15.653154 — cancer biology — Posted on 2025-05-16
2524 Sampling and ranking of protein conformations using machine learning techniques do not improve quality of rigid protein-protein docking
Kyrylenko, R.; Koleiev, I.; Savchenko, I.; Voitsitskyi, T.; Stratiichuk, R.; Husak, V.; Yesylevskyy, S.; Starosyla, S.; Nafiiev, A.
10.1101/2025.05.13.652389 — biophysics — Posted on 2025-05-16
2525 Chip-Based 3D Interferometric Nanoscopy
Wang, W.; Li, H.; Wang, Y.; Barnett, S. F. H.; Huang, Z.; Kanchanawong, P.
10.1101/2025.05.13.653677 — biophysics — Posted on 2025-05-16
2527 RP3Net: a deep learning model for predicting recombinant protein production in Escherichia coli
Tankhilevich, E.; Martinez Cuesta, S.; Barett, I.; Berg, C.; Holmberg Schiavone, L.; Leach, A. R.
10.1101/2025.05.13.652824 — bioinformatics — Posted on 2025-05-16
2532 Sequential Amino Acid Mutagenesis-Driven De Novo Evolution of Adenine Deaminases Enables Efficient In Vivo Base Editing in Primate
Liao, J.; Zhang, H.; Chen, S.; Hsiao, S.; Lai, C.; Feng, H.; Ren, W.; Feng, C.; Xie, D.; Zheng, Y.; Cai, W.; Wang, W.; Jiang, Y.; Wang, D.; Zuo, E.; Wang, Z. J.; Lu, Y.; Wu, Y.
10.1101/2025.05.14.653640 — bioengineering — Posted on 2025-05-16
2533 Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface
Hulleman, J.; Jeon, S.; Bali, S.; DiCesare, S.; Abbas, A.; Daniel, S.; Ortega, A.; Collier, G.; Yang, J.; Bhattacharyaa, A.; McCoy, M.; Joachimiak, L. A.; Posner, B.
10.1101/2025.05.13.651909 — biochemistry — Posted on 2025-05-16
2534 Chromosome-level genome assembly of Norwegian wild alpine reindeer (Rangifer tarandus tarandus)
Torresen, O. K.; Tooming-Klunderud, A.; Skage, M.; Streitlien, A. E.; Strand, O.; Rolandsen, C.; Ferrari, G.; Cerca, J.; Mysterud, A.; Jakobsen, K. S.
10.1101/2025.05.15.652595 — genomics — Posted on 2025-05-16
2535 Empowering medaka fish biology with versatile genomic resources in MedakaBase
Morikami, K.; Tanizawa, Y.; Yagura, M.; Sakamoto, M.; Kawamoto, S.; Nakamura, Y.; Yamaguchi, K.; Shigenobu, S.; Naruse, K.; Ansai, S.; Kuraku, S.
10.1101/2025.05.13.653297 — genomics — Posted on 2025-05-16
2538 Emergent higher-order interactions enable coexistence in phage-bacteria community dynamics
Dey, R.; Coenen, A. R.; Solonenko, N. E.; Burris, M. N.; Mackey, A. I.; Galasso, J.; Sun, C. L.; Demory, D.; Muratore, D.; Beckett, S. J.; Sullivan, M. B.; Weitz, J. S.
10.1101/2025.05.15.651590 — ecology — Posted on 2025-05-16
2539 Honeybees collect pollen from the buzz-pollinated flowers of invasive Solanum elaeagnifolium in Northern Greece
Kantsa, A.; Kariyat, R. R.; Lambert, H.; Nakas, G.; Petanidou, T.; De Moraes, C. M.; Mescher, M. C.
10.1101/2025.05.13.648936 — ecology — Posted on 2025-05-16
2540 Spring ephemeral Erythronium umbilicatum may not be vulnerable to phenological mismatch with overstory trees
Schopler, M.; Simha, A.; Dalton, R. M.; Wilson, E. M.; Redick, E.; Youngsteadt, E.; Petry, W. K.
10.1101/2025.05.14.652260 — ecology — Posted on 2025-05-16
2541 Genetic ablation of Pth4 disrupts calcium-phosphate balance, bone development, and kidney transcriptome in teleosts
Mendez-Martinez, L.; Suarez-Bregua, P.; Guerrero-Pena, L.; Costas-Prado, C.; Barreiro-Docio, E.; Cobelo-Garcia, A.; Rotllant, J.
10.1101/2025.05.13.653078 — developmental biology — Posted on 2025-05-16
2542 The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells
Sanchez, K. R.; Burgess, J. G.; Zheng, Q.; Alam, U.; Neiland, H.; Berwick, R.; Andersson, D.; Korver, S.; Marshall, A.; Goebel, A.; Dong, X.
10.1101/2025.05.15.652596 — immunology — Posted on 2025-05-16
2544 Inhibition of IL2Rβ-dependent STAT5 activity supports T-cell stemness and augments antitumor efficacy of CD8+ T cells by preventing T-cell exhaustion
Shourian, M.; Bourdin, B.; El-Hachem, N.; Ruisseaux, C.; Vallee, A.; Romero, H.; Kwarteng, E. O.; Haddad, E.; Lavallee, V.-P.; Beltra, J.-C.; Decaluwe, H.
10.1101/2025.05.14.651875 — immunology — Posted on 2025-05-16
2547 Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles
Black, A. M.; Komatsu, N.; Zhao, J.; Taskey, S. R.; Serrano, N. S.; Sharma, R.; Manoli, D. S.; Landry, M. P.; Beery, A.
10.1101/2025.05.15.654128 — animal behavior and cognition — Posted on 2025-05-16
2548 Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors
Binagui-Casas, A.; Granes, A.; Ceccarelli, A.; Karagianni, E.; Ramajo, D. L.; Portero, R.; Annoh, J.; French, M.; Wong, F. C. K.; Chara, O.; Lowell, S.; Wilson, V.
10.1101/2025.05.15.654369 — developmental biology — Posted on 2025-05-15
2551 The Ataxin-2 protein is required in Kenyon cells for RNP-granule assembly and appetitive long-term memory formation.
Roselli, C.; Hillebrand, J.; Kaldun, J.; Monteiro, V.; Hurd, T.; Sprecher, S. G.; Boto, T.; Ramaswami, M.
10.1101/2025.05.15.654326 — neuroscience — Posted on 2025-05-15
2554 Fornix subdivisions and spatial learning: a diffusion MRI study
Hodgetts, C. J.; Postans, M.; Williams, A. N.; Graham, K. S.; Lawrence, A. J.
10.1101/2025.05.15.654313 — neuroscience — Posted on 2025-05-16
2555 Contextual High-throughput 3D Volume Electron Microscopy Data Acquisition Using Artificial Intelligence
Konecna, T. H.; Jancik, R.; Slamkova, D.; Pribyl, B.; Tomova, C.; Rotkina, L.; Burch-Smith, T.; Sviben, S.; Fitzpatrick, J. A. J.; Czymmek, K. J.
10.1101/2025.05.15.654255 — cell biology — Posted on 2025-05-15
2556 Actin conformation dynamics precede force generation in cytotoxic T lymphocytes
Rochussen, A. M.; Kebabci, A. O.; Winkel, A. K.; Franze, K.; Fletcher, D. A.; Griffiths, G. M.; Lippert, A. H.
10.1101/2025.05.15.654337 — cell biology — Posted on 2025-05-15
2557 Regulation of Epithelial HIF by Probiotic Escherichia coli
Dowdell, A. S.; Roer, R. L.; Bhagavatula, G.; Cartwright, I. M.; Cohen, R. H.; Countess, J. A.; Koch, S. D.; Lee, J. S.; Steiner, C. A.; Thompson, N. T.; Villamaria, Z. F.; Welch, N. M.; Worledge, C. S.; Zhou, L.; Colgan, S. P.
10.1101/2025.05.14.654147 — cell biology — Posted on 2025-05-15
2559 IntAct-U-ExM: Ultrastructure Expansion microscopy of actin networks via an internally-tagged actin
Dhar, A.; Palani Balaji, N. K.; Mullick, S.; Dey, S.; Ghosh, A.; Nair, D. K.; Gadadhar, S.; Palani, S.
10.1101/2025.05.14.654030 — cell biology — Posted on 2025-05-15
2561 Prg4+ fibro-adipogenic progenitors in muscle are crucial for bone fracture repair
He, Q.; Lu, J.; Liang, Q.; Yao, L.; Sun, T.; Wang, H.; Duffy, M.; Jiang, X.; Lin, Y.; Lee, J.-H.; Ahn, J.; Dyment, N.; Mourkioti, F.; Boerckel, J. D.; Qin, L.
10.1101/2025.05.14.654160 — cell biology — Posted on 2025-05-15
2562 Control of myogenesis by the E3 ubiquitin ligase CUL3-BTBD9
Padovani, C.; Perez, F. R.; Tsai, M.; Xiong, J.; Pogson, A.; Martinez, B.; Rape, M.
10.1101/2025.05.15.654347 — cell biology — Posted on 2025-05-15
2563 Chromatin Protection by the Chromosomal Passenger Complex
Gireesh, A.; Abad Fernandez, M.-A.; Nozawa, R.-S.; Sotelo-Parrilla, P.; Dury, L. C.; Likhodeeva, M.; Spanos, C.; Peralta, C. C.; Rappsilber, J.; Hopfner, K.-P.; Wilson, M. D.; Vanderlinden, W. D.; Hirota, T.; Jeyaprakash, A. A.
10.1101/2025.05.15.654082 — biochemistry — Posted on 2025-05-15
2566 Mycobacterium tuberculosis-infected macrophages accumulate more nanoparticles
Pochet, A.; Bourguignon, T.; Grande, A.; Alfredo Godinez-Leon, J.; Fine, J.; Brodin, P.; Machelart, A.; Gref, R.
10.1101/2025.05.15.654063 — cell biology — Posted on 2025-05-15
2568 Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses
Travers, J.; Huang, E.; McMullen, M. R.; Wu, J.; Cajigas-Du Ross, C. K.; Paouri, E.; Davalos, D.; Pathak, V.; Rotroff, D. M.; Nagy, L. E.
10.1101/2025.05.14.654103 — cell biology — Posted on 2025-05-15
2570 The Environment-Dependent Regulatory Landscape of the E. coli Genome
Roeschinger, T.; Lee, H. J.; Pan, R. W.; Solini, G.; Faizi, K.; Quan, B.; Chou, T. F.; Mani, M.; Quake, S.; Phillips, R.
10.1101/2025.05.13.653802 — molecular biology — Posted on 2025-05-15
2571 Beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual postural task
Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Szul, M. J.; Bonaiuto, J. J.; Bonnefond, M.; Schmitz, C.
10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-05-15
2572 Identification and characterization of a small-molecule inhibitor of the Pseudomonas aeruginosa SOS response
Vascon, F.; Fongaro, B.; Mickevicius, V.; Pasquato, A.; Grybaite, B.; Petraitis, V.; Polverino de Laureto, P.; Tondi, D.; Kavaliauskas, P.; Cendron, L.
10.1101/2025.05.13.651886 — biochemistry — Posted on 2025-05-15
2575 Structural Basis of Herpesvirus Helicase-Primase Inhibition by Pritelivir and Amenamevir
Baranovskiy, A. G.; He, Q.; Suwa, Y.; Morstadt, L. M.; Babayeva, N. D.; Lim, C. J.; Tahirov, T. H.
10.1101/2025.05.15.654119 — biochemistry — Posted on 2025-05-15
2576 Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions
Unnikrishnan, A.; Chung, D. h.; Connelly, E. J.; Chuo, S.-W.; Devi, S.; Thwin, A. C.; Nadel, C. M.; Tse, E.; Gestwicki, J. E.; Craik, C. S.; Southworth, D. R.
10.1101/2025.05.15.654159 — biochemistry — Posted on 2025-05-15
2577 Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity
Milovanovic, D.; Duc, J.; Matsushima, W.; Hamelin, R.; Planet, E.; Offner, S.; Rosspopoff, O.; Trono, D.
10.1101/2025.05.13.653700 — genomics — Posted on 2025-05-15
2578 Identification of a sex-determining locus potentially involved in a conflict over sex-ratio
Lheraud, B.; Dussert, Y.; Chebbi, M. A.; Giraud, I.; Cordaux, R.; Peccoud, J.
10.1101/2025.05.14.654164 — genomics — Posted on 2025-05-15
2581 A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication
Rajasekharan, S.; Barragan Torres, V. A.; Cortes Pinheiro Gomes, Y.; Wilken, L.; Overhoff, K.; Lin, Y.-C.; Patten, S. A.; Watanabe, S.; Chatel-Chaix, L.; Scaturro, P.
10.1101/2025.05.15.653649 — microbiology — Posted on 2025-05-15
2583 Estrous cycle stage gates the effect of stress on reward learning
Johnston, M. P.; Garcia-Castaneda, B. I.; Cedillo, L. G.; Patel, S. K.; Vargas, V. S.; Wanat, M. J.
10.1101/2025.03.23.644830 — neuroscience — Posted on 2025-05-15
2585 Systematic Mapping of Bacterial CRISPRa Design Rules and Implications for Synergistic Gene Activation
Kiattisewee, C.; Karanjia, A. V.; Cardiff, R. A. L.; Olander, K. E.; Leejareon, P.; Alvi, S. S.; Carothers, J. M.; Zalatan, J. G.
10.1101/2025.05.14.654134 — synthetic biology — Posted on 2025-05-15
2586 Peptide nucleic acid (PNA) and DNA hybrid three-way junctions and mesojunctions
Madhanagopal, B. R.; Patel, A.; Talbot, H.; Geary, J. A.; Ganesh, K. N.; Chandrasekaran, A. R.
10.1101/2025.05.15.653195 — synthetic biology — Posted on 2025-05-15
2587 Alternatively-Spliced CAMKK2 isoforms drive differential metabolic stress response and the regulation of ferroptosis
Cheng, S.; Kim, H.; Fahmi, N. A.; Park, M.; Canny, M.; Kukreja, R.; Beckermann, E. J.; Latham, M.; Zhang, W.; Yong, J.
10.1101/2025.05.13.653837 — biochemistry — Posted on 2025-05-15
2588 Antibody targeting the anti-parallel topology of human telomeric G-quadruplex DNA
Reda, N.; Muret, S.; Esteve, C.; Derathe, E.; Susanto, M.-F.; Pitot, E.; Bonnet, H.; Lavergne, T.; Gomez, D.; Dejeu, J.; Scaramozzino, N.; Defrancq, E.
10.1101/2025.05.13.653741 — biochemistry — Posted on 2025-05-15
2589 An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling
Lin, Z.; Xie, Y.; Gongora, J.; Liu, X.; Zahn, E.; Palai, B. B.; Ramirez, D.; Searfoss, R.; Vitorino, F. N.; Karki, R.; Dann, G. P.; Zhao, C.; Han, X.; Mactaggart, B.; Lan, X.; Fu, D.; Greenberg, L.; Zhang, Y.; Lavine, K. J.; Greenberg, M. J.; Lyu, D.; Kashina, A. S.; Garcia, B. A.
10.1101/2024.06.01.596974 — biochemistry — Posted on 2025-05-15
2590 An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks
Cao, Y.; Wang, Y.; Badar, J.; Palek, M.; Jaber, K.; Faca, V. M.; Huang, T.; Celik, E.; Macurek, L.; Smolka, M. B.
10.1101/2025.05.13.652823 — biochemistry — Posted on 2025-05-15
2593 Eukaryotic biodiversity and ecological networks from the surface to the mesopelagic in the Northwest Atlantic Slope Water
Yang, N.; Allan, E. A.; Stover, S. E.; Grassian, B. D.; Sosik, H. M.; Llopiz, J. K.; Govindarajan, A. F.
10.1101/2025.05.12.653512 — ecology — Posted on 2025-05-15
2594 A Short 63-Nucleotide Element Promotes Efficient circRNA Translation
Biagi, M. C.; Giuliani, A.; Grandioso, A.; Bozzoni, I.; Di Timoteo, G.
10.1101/2025.05.13.653105 — molecular biology — Posted on 2025-05-15
2596 Cellular metabolic state controls mitochondrial RNA kinetics
Reardon, S. D.; Bautista, C.; Cole, S. C.; Cicero, J.; Mishanina, T. V.
10.1101/2025.05.13.653903 — molecular biology — Posted on 2025-05-15
2597 WHEP Domain of Glycyl-tRNA Synthetase Regulates Neuropilin 1 Binding and Vascular Permeability
Tong, Y.; Gioelli, N.; Zhang, H.; Dumitru, C. D.; Kanaji, S.; Horii, M.; Cheong, K. N.; Zhou, J.; Bolon, B.; Bai, G.; Serini, G.; Kanaji, T.; Yang, X.-L.
10.1101/2025.05.14.654074 — molecular biology — Posted on 2025-05-15
2599 Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef
Agarwal, M.; Lai, K. K.; Wilt, I.; Majdoul, S.; Jolley, A. A.; Lewinski, M.; Compton, A. A.
10.1101/2025.05.15.654345 — microbiology — Posted on 2025-05-15
2601 The effect of particle size on wheat bran fermentation by human gut microbiota
Fricker, A. D.; Deemer, D. G.; Tuncil, Y. E.; Thakkar, R.; Marcia, A. R.; Emsley, C. W.; Lindemann, S. R.
10.1101/2025.05.15.654185 — microbiology — Posted on 2025-05-15
2603 A novel strategy to mitigate Corynebacterium bovis-associated hyperkeratosis (CAH) in athymic nude mice
Michelson, A.; Cheleuitte-Nieves, C.; Nickerson, K.; Dobtsis, I.; Miranda, I.; Ricart Arbona, R. J.; Wipf, J.; Lipman, N. S.
10.1101/2025.05.15.654331 — microbiology — Posted on 2025-05-15
2605 AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis
Amer, H. M.; Shamseldin, M. M.; Faber, S.; Eltobgy, M.; Webb, A.; El-Mergawy, R.; Chamblee, M.; Perez, R.; Whitham, O.; Badr, A.; Gupta, G.; Omran, J.; Bissel, D.; Yount, J.; Cormet-Boyaka, E.; Boyaka, P. N.; Li, J.; Zhang, X.; Peeples, M. E.; KC, M.; Pietrzak, M.; Seveau, S.; Kokiko-Cochran, O.; Amer, M.; Barrientos, R. M.; Schamess, A.; Oltz, E.; Amer, A. O.
10.1101/2025.05.14.654036 — neuroscience — Posted on 2025-05-15
2606 Magnetic Fields Influence Visual Responses in Mice
Semo, M.; Hughes, S.; Smylie, N. J.; Patton, A. P.; Pothecary, C. A.; Tam, S. K. E.; Buckland, J.; Brown, L. A.; Reardon, P. K.; Bannerman, D. M.; Hastings, M. H.; Peirson, S. N.
10.1101/2025.05.12.653455 — neuroscience — Posted on 2025-05-15
2607 Unusually Broad-spectrum small-molecule sensing using a single protein scaffold
Tian, H.; Beltran, J.; George, W.; Lenert-Mondou, C.; Seder, N.; Davis, Z. I.; Swift, S. D.; Whitehead, T. A.; Girke, T.; Wheeldon, I.; Cutler, S. R.
10.1101/2025.05.15.654352 — synthetic biology — Posted on 2025-05-15
2608 Sustainable production of plastic-degrading enzymes in Chlamydomonas pacifica
Diaz, C. J.; Dutra Molino, J. V.; Saucedo, B.; Kang, K.; do Espirito Santo, E.; Tessman, M.; Gupta, A.; Burkart, M. D.; Simkovsky, R.; Mayfield, S.
10.1101/2025.05.14.654053 — synthetic biology — Posted on 2025-05-15
2610 Identification of disease-specific vulnerability states at the single-cell level
D'Antuono, M.; Sharp, M.; Chowdary, R.; Ivan, M. E.; Komotar, R. J.; Suter, R. K.; Ayad, N. G.
10.1101/2024.12.04.626873 — cancer biology — Posted on 2025-05-15
2612 Overcoming myeloid-driven resistance to CAR T therapy by targeting SPP1
Gholamin, S.; Natri, H. M.; Zhao, Y.; Xu, S.; Aftabizadeh, M.; Comin-Anduix, B.; Saravanakumar, S.; Masia, C.; Wong, R. A.; Peter, L.; Chung, M.-i.; Mee, E. D.; Aguilar, B.; Starr, R.; Torrejon, D. Y.; Alizadeh, D.; Wu, X.; Kalbasi, A.; Ribas, A.; Forman, S.; Badie, B.; Banovich, N.; Brown, C.
10.1101/2025.04.01.646202 — cancer biology — Posted on 2025-05-15
2613 Cleared tissue dual-view oblique plane microscopy
Dvinskikh, L.; Sparks, H.; Ennis, D.; Sarnataro, R.; Carreno, D.; Riglar, D. T.; Cunnea, P.; McNeish, I. A.; Dunsby, C.
10.1101/2025.05.12.653537 — biophysics — Posted on 2025-05-15
2616 Integrating the ENCODE blocklist for machine learning quality control of ChIP-seq with seqQscorer
Albrecht, S.; Krämer, C.; Röchner, P.; Mayer, J. U.; Rothlauf, F.; Andrade-Navarro, M. A.; Sprang, M.
10.1101/2025.05.12.653555 — bioinformatics — Posted on 2025-05-15
2619 DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation
Yonezawa, T.; Rutter, J.; Ramabadran, R.; Sundaramurthy, V.; Datar, G.; Slabicki, M.; Goodell, M. A.
10.1101/2025.03.05.641683 — biochemistry — Posted on 2025-05-15
2620 Identifying genomic adaptation to local climate using a mechanistic evolutionary model
Goel, N.; Bossu, C. M.; Van Ee, J. J.; Zavaleta, E.; Ruegg, K. C.; Hooten, M. B.
10.1101/2024.11.21.624744 — genomics — Posted on 2025-05-15
2625 Temperature-dependent predation predicts a more reptilian future
Grady, J. M.; Amme, J. L.; Bhaskaran-Nair, K.; Sinha, V.; Brunwasser, S. J.; Read, Q. D.; Record, S.; Dell, A. I.; Hengen, K. B.
10.1101/2024.09.19.613816 — ecology — Posted on 2025-05-15
2626 Sediment-associated processes account for most of the spatial variation in ecosystem respiration in the Yakima River basin
Garayburu-Caruso, V.; Kaufman, M.; Forbes, B.; Hall, R.; Laan, M.; Chen, X.; Lin, X.; Fulton, S.; Renteria, L.; Fang, Y.; Son, K.; Stegen, J. C.
10.1101/2024.03.22.586339 — ecology — Posted on 2025-05-15
2630 Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I
Leng, H.; jiang, j.; Gassner, K.; Midha, S.; Justo-Mendez, R.; Zheng, J.; Hall, T.; Luo, L.; West, S. D.; Vincent, T. L.; Wann, A.; Patel, K. A.; Poulton, J.; O'Callaghan, C. A.; Lechuga-Vieco, A. V.; Simon, A. K.
10.1101/2025.05.02.651799 — cell biology — Posted on 2025-05-15
2631 nERdy: network analysis of endoplasmic reticulum dynamics
Samudre, A.; GAO, G.; Cardoen, B.; Joshi, B.; Nabi, I. R.; Hamarneh, G.
10.1101/2024.02.20.581259 — cell biology — Posted on 2025-05-15
2632 Reduced cell-substrate adhesion formation promotes cell migration in Dictyostelium
Fierro Morales, J. C.; Nguyen, T.; Nepal, S.; Redfearn, C.; Gale, B. K.; Titus, M. A.; Roh-Johnson, M.
10.1101/2024.03.19.585764 — cell biology — Posted on 2025-05-15
2633 Does local adaptation influence thermal responses in red coral populations across depth gradients? Transcriptomic insights for effective conservation.
Ramirez-Calero, S. P.; Garrabou, J.; Suresh, S.; Gut, M.; Jou, M.; Sarropoulou, X.; Lopez-Sendino, P.; Zabala, M.; Ledoux, J.-B.
10.1101/2025.05.12.653513 — molecular biology — Posted on 2025-05-15
2640 Automated high-throughput patch clamp electrophysiology of hiPSC-derived neuronal models
Farinelli, F.; Ostlund, I.; Sripathy, S. R.; Das, D.; Shim, G.; Myung, S.; Straub, R. E.; Maher, B. J.
10.1101/2025.05.12.653142 — neuroscience — Posted on 2025-05-15
2641 Data Heterogeneity Limits the Scaling Effect of Pretraining Neural Data Transformers
Jiang, L. P.; Chen, S.; Tanumihardja, E.; Han, X.; Shi, W.; Shea-Brown, E.; Rao, R. P. N.
10.1101/2025.05.12.653551 — neuroscience — Posted on 2025-05-15
2645 Recurrent cortical networks encode natural sensory statistics via sequence filtering
Deveau, C.; Zhou, Z.; LaFosse, P. K.; Deng, Y.; Mirbagheri, S.; Steinmetz, N.; Histed, M. H.
10.1101/2024.02.24.581890 — neuroscience — Posted on 2025-05-15
2647 Human- and Rodent-derived Extracellular Vesicles Mediate the Spread of Pathology in MSA-like Models
Vetsi, M.; Dionysopoulou, D.; Mavroeidi, P.; Arvanitaki, F.; Tsaka, G.; Lopez, E. M.; Giannopoulou, M.; Fortis, S.; Kriebardis, A.; Becker, S.; Zachrdla, M.; Omori, M.-S. C.; Kloukina, I.; Tremi, I.; Havaki, S.; Gorgoulis, V.; Stefanova, N.; Jensen, P. H.; Zweckstetter, M.; Xilouri, M.
10.1101/2025.05.12.653337 — neuroscience — Posted on 2025-05-15
2648 PEtab Select: specification standard and supporting software for automated model selection
Pathirana, D.; Bergmann, F. T.; Doresic, D.; Lakrisenko, P.; Persson, S.; Neubrand, N.; Timmer, J.; Kreutz, C.; Binder, H.; Cvijovic, M.; Weindl, D.; Hasenauer, J.
10.1101/2025.05.12.653312 — systems biology — Posted on 2025-05-15
2649 G Protein Coupled Estrogen Receptor Signaling Maintains β Cell Identity in Female Mice
McLaughlin, M. R.; Krishnan, P.; Wu, W.; Rostron, C.; Orr, K.; Udari, L.; Del Carmen Aquino, J.; Fisher, A.; Kono, T. M.; Kua, K. L.; Evans-Molina, C.
10.1101/2025.05.12.652914 — physiology — Posted on 2025-05-15
2650 Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations
Suter, R. K.; Jermakowicz, A.; Veeramachaneni, R.; D'Antuono, M.; Zhang, L.; Chowdary, R.; Kaeppeli, S.; Sharp, M.; Palwai, P.; Stathias, V.; Baker, G.; Ruiz, L. C.; Walters, W.; Cepero, M.; Burgenske, D.; Reilly, E. B.; Oleksijew, A.; Anderson, M. G.; Williams, S. L.; Ivan, M. E.; Komotar, R. J.; De La Fuente, M. I.; Stein, G.; Kesari, S.; Sarkaria, J. N.; Schürer, S.; Ayad, N. G.
10.1101/2025.05.15.654044 — cancer biology — Posted on 2025-05-15
2651 Cellular characterization of the peritumoral brain zone of glioblastomas: heterogenous nature and clinical relevance.
deDios, O.; Romero, J.; Ramirez-Gonzalez, M.; Herranz-Sanchez, B.; Avis, A.; Ramos, A.; Sepulveda-Sanchez, J. M.; Gargini, R.; Segura-Collar, B.; Velilla, G.; Melendez, B.; Gonzalez, P.; Jimenez-Roldan, L.; Garcia-Posadas, G.; Hernandez-Lain, A.; Perez-Nunez, A.; Sanchez-Gomez, P.
10.1101/2025.03.09.633849 — cancer biology — Posted on 2025-05-15
2653 Voxelotor (Oxbryta) Binds Multiple Hemoglobin Sites and Influences Protein Structure
Tamanaha, M. d. l. C.; Cabrera, E. F.; Sargeant, J.; Gershon, P. D.; Russell, P. P. S.; Cocco, M. J.
10.1101/2025.05.12.653546 — biophysics — Posted on 2025-05-15
2655 GPU-accelerated homology search with MMseqs2
Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.
10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-05-15
2658 High-Sensitivity Top-Down Proteomics Reveals Enhanced Maturation of Micropatterned Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Wilson, M. C.; Josvai, M.; Walters, J. K.; Lawson, J.; Rossler, K. J.; Gao, Z.; Zhu, Y.; Kamp, T. J.; Crone, W.; Eckhardt, L. L.; Ge, Y.
10.1101/2025.05.12.653499 — molecular biology — Posted on 2025-05-15
2659 HIV-1 Amplifies IL-8 Response Of Human Stellate Cells To Gram-Positive Microbial Products Via H4K5 Histone Acetylation
Zhang, L.; Ali, R. O.; Chamroonkul, N.; Tabrizian, P.; Schwartz, M.; Gunasekaran, G.; Schiano, T.; Fiel, M. I.; Ward, S.; Bansal, M. B.
10.1101/2025.05.12.653460 — immunology — Posted on 2025-05-15
2660 Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models
Martin, A. K.; Hedberg, J.; Hernandez Aguirre, I.; Saini, U.; Kim, D.; Kim, Y.; Dhital, R.; Cassady, K. A.
10.1101/2025.05.12.653429 — immunology — Posted on 2025-05-15
2663 Defining conservation units in a highly diverse species: A case on Arctic charr
Fenton, S.; Bean, C. W.; Martin, S. A. M.; Poultney, S. J.; Smith, A.; de Eyto, E.; Elmer, K. R.; Adams, C. E.
10.1101/2025.05.12.653098 — genomics — Posted on 2025-05-15
2664 CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans
Draber, P.; Semberova, T.; Pribikova, M.; Kissiova, H.; Trivic, T.; Stepanek, O.
10.1101/2025.05.12.653457 — immunology — Posted on 2025-05-15
2665 The plant-time-bender model: predicting yield through wheat's perception of time
Roth, L.; Herrera, J. M.; Levy Häner, L.; Pellet, D.; Fossati, D.; Boss, M.; Chen, X.; Nousi, P.; Volpi, M.
10.1101/2025.05.12.653430 — genomics — Posted on 2025-05-15
2666 African Cichlid Lake Radiations Recapitulate Riverine Axial Morphologies Through Repeated Exploration of Morphospace
Bucklow, C. V.; Ribeiro, E. D.; Ronco, F.; Vranken, N.; Oliver, M. K.; Salzburger, W.; Stiassny, M.; Benson, R.; Verd, B.
10.1101/2025.05.13.653847 — evolutionary biology — Posted on 2025-05-15
2667 Eukaryotic biodiversity and ecological networks from the surface to the mesopelagic in the Northwest Atlantic Slope Water
Yang, N.; Allan, E. A.; Stover, S. E.; Grassian, B. D.; Sosik, H. M.; Llopiz, J. K.; Govindarajan, A. F.
10.1101/2025.05.12.653512 — ecology — Posted on 2025-05-15
2672 Community-promoted antibiotic resistance genes show increased dissemination among pathogens
Lund, D.; Johnning, A.; Holmström, M.; Varghaei, L.; Inda-Diaz, J. S.; Bengtsson-Palme, J.; Kristiansson, E.
10.1101/2025.05.12.653433 — bioinformatics — Posted on 2025-05-15
2674 NvashA function reveals temporal differences in neural subtype generation in cnidarians
Havrilak, J. A.; Cheng, M.; Al-Shaer, L.; Leach, W. B.; Yagodich, M.; Faltine-Gonzalez, D. Z.; Layden, M. J.
10.1101/2025.05.12.653478 — developmental biology — Posted on 2025-05-15
2678 The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events
Onimus, O.; Arrivet, F.; Le Borgne, T.; Perez, S.; Castel, J.; Ansoult, A.; Bertrand, B.; Mashhour, N.; de Almeida, C.; Bui, L.-C.; Vandecasteele, M.; Luquet, S.; Venance, L.; Heck, N.; Marti, F.; Gangarossa, G.
10.1101/2025.05.12.653303 — neuroscience — Posted on 2025-05-15
2679 Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer
Keumoe, R.; Kouipou, R. M. T.; Madiesse, E. A. K.; Fokou, J. B. H.; Dize, D.; Fokou, P. V. T.; Kamdem, B. P.; Makembe, A. H. E.; Njionhou, M. S. N.; Ghoshal, A.; Kundu, A.; Laleu, B.; Boyom, F. F.
10.1101/2025.05.12.653443 — pharmacology and toxicology — Posted on 2025-05-15
2680 Promising protocol for in vivo experiments with betulin
Siman, P.; Bezrouk, A.; Ticha, A.; Kozakova, H.; Hudcovic, T.; Kucera, O.; Niang, M.
10.1101/2025.05.12.653392 — pharmacology and toxicology — Posted on 2025-05-15
2682 Rotiferometer: an automated system for quantification of rotifer cultures
Diouf, A.; Bereziat, L.; Nodier, D.; Amaral, M.; Haliyo, S.; MANNIOUI, A.
10.1101/2025.05.12.653399 — bioengineering — Posted on 2025-05-15
2686 Slow RNAPII elongation enhances naive-pluripotency rewiring while preserving replication fork speed
Martin-Virgala, S.; Segura, J.; Gallego, A.; Isoler-Alcaraz, J.; Schermelleh, L.; Gomez, M.
10.1101/2025.05.12.653265 — molecular biology — Posted on 2025-05-15
2688 Absence of Systematic Effects of Internalizing Psychopathology on Learning Under Uncertainty
Satti, M. H.; Wille, K.; Nassar, M. R.; Cichy, R. M.; Schuck, N. W.; Dayan, P.; Bruckner, R.
10.1101/2025.05.12.653409 — neuroscience — Posted on 2025-05-15
2689 Proteomics-based models of gene expression and cellular control of cotton fiber development
Lee, Y.; Yang, P.; Rani, H.; Miller, G.; Grover, C. E.; Swaminathan, S.; Zabotina, O. A.; Wendel, J. F.; Xie, J.; Szymanski, D. B.
10.1101/2025.02.05.636703 — plant biology — Posted on 2025-05-15
2690 Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis
Anderson, S. E.; Hymel, L. A.; Zhang, H.; McKinney, J. M.; Turner, T. C.; Mohiuddin, M.; Han, W. M.; Lee, N. H.; Choi, J. J.; Jeong, G.; Greenwood, E.; Chatterjee, P.; Lee, S.; Gibson, G.; Wood, L. B.; Botchwey, E. A.; Jang, Y. C.; Willett, N. J.
10.1101/2025.05.11.653339 — pathology — Posted on 2025-05-15
2691 Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma
van Oost, S.; Meijer, D. M.; Erdem, Z. B.; IJsselsteijn, M. E.; Roelands, J.; Lam, S. W.; Boejharat, M. S.; van den Akker, B. E. W. M.; van der Breggen, R.; Briaire-de Bruijn, I. H.; Hawinkels, L. J. A. C.; Kruiswijk, A. A.; van der Ploeg, M.; Wijers-Koster, P. M.; Haas, R. L.; van de Sande, M. A. J.; de Miranda, N. F. C. C.; Bovee, J. V. M. G.
10.1101/2025.03.27.645727 — cancer biology — Posted on 2025-05-15
2692 Leveraging Large Language Models for Literature-Driven Prioritization of Protein Binding Pockets
Stratiichuk, R.; Melnychenko, M.; Koleiev, I.; Voitsitskyi, T.; Vladyslav, H.; Shevchuk, N.; Osrovsky, Z.; Bdzhola, V.; Yesylevskyy, S.; Starosyla, S.; Nafiiev, A.
10.1101/2025.05.13.653394 — biophysics — Posted on 2025-05-15
2694 Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Broske, B.; Binder, S. C.; McEnroe, B. A.; Kempchen, T. N.; Fandrey, C. I.; Messmer, J. M.; Tan, E.; Konopka, P.; Ferber, D.; Yong, M. C. R.; Kleinert, M.; Hoch, A.; Blumenstock, K.; Tödtmann, J. M. P.; Oldenburg, J.; Rühl, H.; Semaan, A.; Toma, M. I.; Markova, K.; Kobold, S.; Rollenske, T.; Geyer, M.; Menzel, S.; Bald, T.; Schmid-Burgk, J. L.; Hagelueken, G.; Hölzel, M.
10.1101/2025.05.11.652819 — bioengineering — Posted on 2025-05-15
2695 DNA extrusion size determines pathway choice during CAG repeat expansion
Bhatia, M.; Phadte, A. S.; Lakhina, A.; Monte Carlo, A. R.; Barndt, S.; Pluciennik, A.
10.1101/2025.05.12.653571 — biochemistry — Posted on 2025-05-15
2700 Macromolecular interactions dictate Polycomb-mediated epigenetic repression
Much, C.; Rajkumar, S. M.; Chen, L.; Cohen, J. M.; Gade, A. R.; Pitt, G. S.; Long, Y.
10.1101/2025.05.15.654236 — molecular biology — Posted on 2025-05-15
2701 High-intensity interval exercise affects explicit sequential motor consolidation with both physical and mental practice
Digonet, G.; Lapole, T.; Gelebart, J.; Bouvier, J.; Blanco, L.; Magaud, J.; Pialoux, V.; Pingon, M.; Stauffer, E.; Debarnot, U.
10.1101/2025.05.10.653061 — neuroscience — Posted on 2025-05-15
2704 Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
Liu, Y.; Rao, S.; Hoskins, I.; Geng, M.; Zhao, Q.; Chacko, J.; Ghatpande, V.; Qi, K.; Persyn, L.; Wang, J.; Zheng, D.; Zhong, Y.; Park, D.; Cenik, E. S.; Agarwal, V.; Ozadam, H.; Cenik, C.
10.1101/2024.08.11.607360 — bioinformatics — Posted on 2025-05-15
2705 Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells
Hoch, A.; Fandrey, C. I.; Coventry, B.; Virreira Winter, S.; Geyer, P. E.; Kempchen, T. N.; Ebert, T. S.; Hoelzel, M.; Baker, D.; Schmid-Burgk, J. L.
10.1101/2025.05.11.653342 — bioengineering — Posted on 2025-05-15
2708 Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools used in Malaria control
Njoroge, H.; Namuli, L.; Nagi, S. C.; Hernandez-Koutoucheva, A.; McDermott, D. P.; Knight, E.; Gonahasa, S.; Lynd, A. R.; Oruni, A.; Maiteki-Sebuguzi, C.; Opigo, J.; Yeka, A.; Katureebe, A.; Kyohere, M.; Kamya, M.; Dorsey, G.; hemingway, J.; Staedke, S.; Clarkson, C. S.; Miles, A.; Lucas, E. R.; Donnelly, M. J.
10.1101/2025.05.12.653619 — genomics — Posted on 2025-05-15
2711 Species-specific, multifaceted venom resistance in Monodelphis domestica reveals novel physiological behavior of von Willebrand Factor under flow.
Holding, M. L.; Disharoon, D.; Haynes, L. M.; Paruchuri, B. C.; Pontius, M. H. H.; Golden, K.; Shavit, J. A.; Desch, K.; Ginsburg, D.; Sen Gupta, A.; Cruz, Y. P.; Drabeck, D.
10.1101/2025.01.21.634112 — evolutionary biology — Posted on 2025-05-15
2715 SmartEM: machine-learning guided electron microscopy
Meirovitch, Y.; Chandok, I. S.; Park, C. F.; Potocek, P.; Mi, L.; Sawmya, S.; Li, Y.; Athey, T. L.; Susoy, V.; Karlupia, N.; Wu, Y.; Berger, D. R.; Schalek, R.; Bishop, C.; Xenes, D.; Martinez, H.; Matelsky, J.; Wester, B. A.; Pfister, H.; Schoenmakers, R.; Peemen, M.; Lichtman, J. W.; Samuel, A.; Shavit, N.
10.1101/2023.10.05.561103 — neuroscience — Posted on 2025-05-15
2716 Hierarchical Heterogeneities in Spatio-Temporal Dynamics of the Cytoplasm
Moeckel, C.; Biswas, A.; Reber, S.; Chechkin, A.; Zaburdaev, V.; Guck, J.
10.1101/2025.05.08.652886 — biophysics — Posted on 2025-05-15
2717 Spatial geometry-aware deep learning for deciphering tissue structure from spatially resolved transcriptomics
Li, X.; Jia, X.; Zhao, D.; Xu, J.; Du, G.; Qi, Y.; Chen, Y.; Wu, Y.; Zhu, J.; Wei, F.; Shang, X.
10.1101/2025.05.11.652625 — bioinformatics — Posted on 2025-05-15
2719 MARTS-DB: A Database of Mechanisms And Reactions of Terpene Synthases
Engst, M.; Brokes, M.; Calounova, T.; Tajovska, A.; Perkovic, M.; Samusevich, R.; Chatpatanasiri, R.; Pluskal, T.
10.1101/2025.05.11.653183 — bioinformatics — Posted on 2025-05-15
2722 Kinetics of de novo Bone and Bone Marrow Niche Formation with Hybrid Click Cryogels
Lee, S.; Adu-Berchie, K.; Sharda, A. S.; To, T.; Dimitrakakis, N.; Stafford, A.; Sheehan, K.; Johnson, C.; Ijaz, H.; Kwon, P.; Cartwright, M.; Elmehrath, S.; Skolfield, M. C.; White, D.; Williams, M.; Super, M.; Scadden, D. T.; Mooney, D. J.
10.1101/2025.05.12.653550 — bioengineering — Posted on 2025-05-15
2723 Characterization of cytokine treatment on human pancreatic islets by top-down proteomics
Ives, A. N.; Sagendorf, T.; Nierves, L.; Lin, T.-T.; Dirice, E.; Kulkarni, R. N.; Pasa-Tolic, L.; Qian, W.-J.; Fulcher, J. M.
10.1101/2025.05.12.653562 — biochemistry — Posted on 2025-05-15
2725 CapTrap-seq: Advancing zebrafish transcriptomic research through high-fidelity full-length RNA sequencing
Kwiatkowska, M.; Blangiewicz, M.; Madry, T.; Carbonell-Sala, S.; Guigo, R.; Uszczynska-Ratajczak, B.
10.1101/2025.05.12.653332 — genomics — Posted on 2025-05-15
2726 Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia
Khalaf, A.; Zhou, C.; Weber, C. C.; Vancaester, E.; Sims, Y.; Makunin, A.; Mathers, T. C.; Absolon, D. E.; Wood, J. M.; McCarthy, S. A.; Jaron, K.; Blaxter, M.; Lawniczak, M. K.
10.1101/2025.05.12.652816 — genomics — Posted on 2025-05-15
2727 First chromosome scale genome of Acrocomia aculeata
Scaketti, M.; Garcia, C. B.; Araujo, J. V. d. S. R.; de Carvalho, I. A. S.; Marroquin, J. A. M.; Riano-Pachon, D. M.; Neto, D. D.; Labate, C. A.; Vicentini, R.; Pinheiro, J. B.; Vianna, S.; Colombo, C.; Zucchi, M. I.
10.1101/2025.05.12.653347 — genomics — Posted on 2025-05-15
2729 Deep homology and design of proteasome chaperone proteins in Candida auris
Rapala, J. R.; Siddiq, M.; Wittkopp, P. J.; O'Meara, M. J.; O'Meara, T. R.
10.1101/2025.05.14.654010 — evolutionary biology — Posted on 2025-05-15
2733 Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration
Tan, C.; Liu, Z.; Mao, X.; Zhang, Y.; Li, X.; Pek, N.; Fu, H.; Liu, Y.; Kalinichenko, V. V.; Pryhuber, G. S.; Lu, R.; Lai, L.; Miao, Y.; Guo, M.; Gu, M.
10.1101/2025.05.11.653351 — developmental biology — Posted on 2025-05-15
2736 Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via PHACTR1 Regulation
Tay, K. Y.; Wee, H. S.; Nguyen, N.; Autio, M. I.; Wazny, V. K.; Lee, K. L.; Tay, D.; Wang, Y.; Gao, X.; Heng, C. K.; Chan, M. Y.; Foo, R. S.; Lee, J.; Loh, M.; Cheung, C.
10.1101/2025.05.11.653298 — molecular biology — Posted on 2025-05-15
2739 Euprymna berryi as a comparative model host for Vibrio fischeri light organ symbiosis
Imes, A. M.; Pavelsky, M.; Badal, K.; Kamp, D. L.; Briseno, J. L.; Sakmar, T.; Vogt, M. A.; Nyholm, S. V.; Heath-Heckman, E.; Grasse, B.; Septer, A. N.; Mandel, M. J.
10.1101/2025.01.10.632448 — microbiology — Posted on 2025-05-15
2740 Robust TCR production for the structural study of TCR-pMHC complexes
Oyon-Olea, L.; Dichiara-Rodriguez, M. G.; Hervas-Stubbs, S.; Erausquin, E.; Lopez-Sagaseta, J.
10.1101/2025.05.12.653033 — immunology — Posted on 2025-05-15
2743 An 'Aha!' moment precedes the strategic response to a visuomotor rotation
Townsend, M.; Warburton, M.; Campagnoli, C.; Mon-Williams, M.; Mushtaq, F.; Morehead, J. R.
10.1101/2025.05.11.653302 — neuroscience — Posted on 2025-05-15
2744 Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology
Nemec, K. M.; Uy, G.; Chaluvadi, V. S.; Purnell, F. S.; Elfayoumi, B.; Byerly, L.; O'Reilly, M. L.; O'Brien, C. A.; Aisenberg, W. H.; Lombroso, S. I.; Guo, X.; Blank, N.; Oon, C. H.; Yaqoob, F.; Temsamrit, B.; Rawat, P.; Thaiss, C. A.; Bailis, W.; Williamson, A. P.; Wang, Q.; Bennett, M. L.; Bennett, F. C.
10.1101/2024.09.18.613629 — neuroscience — Posted on 2025-05-15
2745 NodoMap: a spatio-cellular map of the mouse nodose ganglia
Cheng, S.; Dowsett, G. K. C.; Rainbow, K.; Norton, M.; Roberts, A. G.; Phuah, P.; Bewick, G. A.; Lam, B. Y.; Yeo, G. S. H.; Murphy, K.
10.1101/2025.05.11.653249 — physiology — Posted on 2025-05-15
2747 Targeting of CIP4-Calcineurin Signalosomes Improves Cardiac Structure and Function After Myocardial Infarction
Samuelsson, A.-M.; Bayer, A. L.; Li, J.; Li, Y.; Lewis, D.; Turcotte, M.; Dodge-Kafka, K.; Alcaide, P.; Kapiloff, M. S.
10.1101/2025.05.12.653597 — physiology — Posted on 2025-05-15
2748 Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression
Ha, H. T.; Kosmynina, S.; Verocq, A.; Ozen, K.; Tekia, I.; Bussy, H.; Sabbah, D.; Goemans, C.; Vandenbempt, V.; Gurzov, E. N.; Singh, S. P.; Baeyens, N.
10.1101/2025.05.11.653296 — pathology — Posted on 2025-05-15
2752 Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation
Ausserwoeger, H.; Scrutton, R. M.; Sneideris, T.; Fischer, C. M.; Qian, D.; de Csillery, E.; Baronaite, I.; Saar, K. L.; Bialek, A. Z.; Oeller, M. M.; Krainer, G.; Franzmann, T. M.; Wittmann, S.; Iglesias-Artola, J. M.; Invernizzi, G.; Hyman, A. A.; Alberti, S.; Lorenzen, N.; Knowles, T. P. J.
10.1101/2024.05.23.595321 — biophysics — Posted on 2025-05-15
2753 Artificial Intelligence And First Principle Methods In Protein Redesign: A Marriage Of Convenience?
Cianferoni, D.; Vizarraga Revuelto, D.; Fernandez Escamilla, A. M.; Fita, I.; Hamdani, R.; Reche, R.; Delgado, J.; Serrano Pubul, L.
10.1101/2025.05.12.653318 — bioinformatics — Posted on 2025-05-15
2757 A Multimodal Graph Learning Framework for Versatile Spatial Transcriptomics Analysis with SpatialModal
Li, X.; Zhao, D.; Jia, X.; Du, G.; Xu, J.; Qi, Y.; Chen, Y.; Wu, Y.; Zhu, J.; Wei, F.; Li, M.; Shang, X.
10.1101/2025.05.11.653070 — bioinformatics — Posted on 2025-05-15
2758 Evaluating Foundation Models for In-Silico Perturbation
Liu, X.; Boylan, J.; Bouiller, T.; Solovyeva, E.; Ataman, B.; Hoersch, S.; Jenkins, J.; Devarakonda, M.
10.1101/2025.05.11.653338 — bioinformatics — Posted on 2025-05-15
2760 scDenorm: a denormalisation tool for integrating single-cell transcriptomics data
Huang, Y.; Pournara, A. V.; Ao, Y.; Yang, L.; Zhang, H.; Zhang, Y.; Liu, S.; Brazma, A.; Papatheodorou, I.; Yang, X.; Shi, M.; Miao, Z.
10.1101/2025.05.10.653289 — bioinformatics — Posted on 2025-05-15
2761 High-temporal-resolution point-of-care multiplex biomarker monitoring in small animals using microfluidic digital ELISA
Song, Y.; Stephens, A. D.; Deng, H.; Fueredi, A. D.; Su, S. H.; Ye, Y.; Chen, Y.; Newstead, M. W.; Yin, Q.; Lehto, J.; Fahim, Z.; Singer, B. H.; Kurabayashi, K.
10.1101/2025.05.11.653356 — bioengineering — Posted on 2025-05-15
2763 Switching ON Hydrogen Sulfide: A Chemogenetic Toolkit for Spatially Resolved H2S Manipulation
Ghaffari Zaki, A.; Miri, S. M.; Vatandaslar, E.; Vilain, S.; Yigit, E. N.; Aydin, M. S.; Alp, M. I.; Eroglu, E.
10.1101/2025.05.12.653628 — biochemistry — Posted on 2025-05-15
2766 Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Laboy, R.; Ndoci, M.; Tabrez, S. S.; Vonolfen, M.; Ballhysa, E.; Droth, T.; Schilling, K.; Loehrke, A.; Atanassov, I.; Antebi, A.
10.1101/2023.06.14.544948 — cell biology — Posted on 2025-05-15
2768 Injectable Immune-Engineered Hydrogel Niche Remote From The Immune Suppressed Tumor Microenvironment For Cancer Immunotherapy
Muhammad, S. N.; Zakariya, Z. T.; Shaji, S.; Sunilkumar, A. K.; George, A.; Radhakrishnan, S. P.; Nair, S. V.; Koyakutty, M.
10.1101/2025.05.11.653292 — immunology — Posted on 2025-05-15
2770 Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease
Sakai, S.; Otani, K.; Tsuyama, J.; Hara, Y.; Abe, K.; Shimamura, T.; Kawakami, I.; Komori, T.; Kawaji, H.; Hase, K.; Saito, T.; Shichita, T.
10.1101/2025.05.12.653388 — neuroscience — Posted on 2025-05-15
2771 Influence of neck tissue conductivities on the phrenic nerve activation threshold during non-invasive electrical stimulation
Wegert, L.; Di Rienzo, L.; Codecasa, L.; Ziolkowski, M.; Hunold, A.; Kalla, T.; Lange, I.; Haueisen, J.
10.1101/2025.05.12.653397 — neuroscience — Posted on 2025-05-15
2772 SARM1 is an essential component of neuronal Parthanatos
Wu, T.; Yuan, L.; Sasaki, Y.; Buchser, W.; Bloom, J.; DiAntonio, A.; Milbrandt, J.
10.1101/2025.05.14.654090 — neuroscience — Posted on 2025-05-15
2774 Biomimetic self-regulation in intrinsically motivated robots
Guerrero Rosado, O.; Fernandez Amil, A.; Tito Freire, I.; Vinck, M.; F.M.J. Verschure, P.
10.1101/2025.05.11.653305 — neuroscience — Posted on 2025-05-15
2783 Identifying myocardial regions perfused by coronary arteriesthrough detailed human microvasculature data
Montino Pelagi, G.; Mackenzie, J. A.; van Bavel, E. A.; Valbusa, G.; Vergara, C.; Hill, N. A.
10.1101/2025.05.12.653398 — bioengineering — Posted on 2025-05-15
2784 A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation
Lacoursiere, R. E.; Upadhyaya, K.; Kaur Sidhu, J.; Bejan, D. S.; Rodriguez Siordia, I.; Cohen, M. S.; Pruneda, J. N.
10.1101/2025.05.11.653360 — biochemistry — Posted on 2025-05-15
2786 Age-trajectory of mother-infant relationships in wild Assamese macaques
Arbaiza-Bayona, A. L.; Mundry, R.; Malaivijitnond, S.; Meesawat, S.; Schulke, O.; Ostner, J.
10.1101/2025.05.10.653242 — animal behavior and cognition — Posted on 2025-05-15
2789 UV laser crosslinking uncovers novel DNA-binding pattern of CTCF
Stanko, C.; Oezcan, S. G.; Stengel, S.; Szymanski, L.; Steube, A.; Fischer, M.; Brioli, A.; Schenk, T.
10.1101/2025.05.12.653382 — genomics — Posted on 2025-05-15
2790 Intra-Strain Genetic Heterogeneity in Toxoplasma gondii ME49: Oxford Nanopore Long-Read Sequencing Reveals Copy Number Variation in the ROP8-ROP2A Locus
Gohar, Y.; Neumann, M.; Huelse, L.; Wind, D.; Mock, J.; Buchholz, K.; Helle, M.; Sorg, U. R.; Degrandi, D.; Pfeffer, K.; Dilthey, A. T.
10.1101/2025.05.10.653050 — genomics — Posted on 2025-05-15
2792 Development and application of a genotyping by target sequencing SNP array panel in Salix suchowensis
Han, Y.; Gu, S.; Zhu, M.; Liu, W.; Feng, L.; Yin, T.; Gao, X.; Zan, Y.; Ji, Y.; Liu, J.
10.1101/2025.05.12.653369 — genetics — Posted on 2025-05-15
2793 Advancing global DNA-referencing of bushmeat in African tropical forests: a tool for identifying trade hotspots and dynamics in western and central Africa
Pires, D.; Gomes, C.; Groom, B.; Dufour, S.; Danquah, E.; Van Vliet, N.; Ayecaba, G. N.; Missoup, A. D.; Afiademanyo, K.; Djagoun, C. S.; Gonedele, S. B.; Chaber, A.-L.; Olayemi, A.; Antunes, A.; Gaubert, P.
10.1101/2025.05.12.653485 — genetics — Posted on 2025-05-15
2795 An early evolutionary stage of mutualistic endosymbiosis reveals a parasitic aspect of endosymbionts
Kamal, M. M.; Cheng, Y.-H.; Chu, L.-W.; Nguyen, P. T.; Jeff Liu, C.-F.; Liao, C.-W.; Posch, T.; Leu, J.-Y.
10.1101/2025.05.12.653378 — evolutionary biology — Posted on 2025-05-15
2798 Application of post glycosylation modifying enzymes for mass spectrometry imaging of modified N-glycans in situ.
Dreifus, J. E.; Chuzel, L.; Escobar, E. E.; Grimsley, G.; Bai, H.; Hanneman, A. J.; Fossa, S. L.; Gregory, V.; Martin, R. J.; Drake, R. R.; Foster, J.; Taron, C. H.
10.1101/2025.05.14.654078 — molecular biology — Posted on 2025-05-15
2802 Disrupted salience network dynamics during the imagery of migraine attacks
Esteves, I.; Perdigao, A.; Fouto, A. R.; Ruiz-Tagle, A.; Caetano, G.; Cabral, J.; Martins, I. P.; Gil-Gouveia, R.; Caballero-Gaudes, C.; Figueiredo, P.
10.1101/2025.05.10.653239 — neuroscience — Posted on 2025-05-15
2803 Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals: A neuromelanin-sensitive MRI study
Etani, T.; Nakajima, S.; Honda, S.; Homma, S.; Kaneko, Y.; Kondoh, S.; Tarumi, R.; Tsugawa, S.; Moriyama, S.; Tobari, Y.; Samma, T.; Horga, G.; Cassidy, C.; Uchida, H.; Fujii, S.
10.1101/2025.05.10.653047 — neuroscience — Posted on 2025-05-15
2804 Unreliable homeostatic action potential broadening in cultured dissociated neurons
Ritzau-Jost, A.; Rajayer, S.; Nerlich, J.; Maciag, F.; John, A.; Russier, M.; Gonzalez Sabater, V.; Steiger, L.; Coq, J.-O.; Eilers, J.; Engelhardt, M.; Burrone, J.; Debanne, D.; Heine, M.; Smith, S. M.; Hallermann, S.
10.1101/2025.05.09.653135 — neuroscience — Posted on 2025-05-15
2806 Physical activity promotes gut adaptation, responses to nutrients, and sensitivity to gut peptides
Baech-Laursen, C.; Vergara Ucin, J.; Galsgaard, K. D.; Llana, J.; Kissow, H.; Holst, J. J.; Pedersen, B. K.; Sanchis, P.
10.1101/2025.05.12.653520 — physiology — Posted on 2025-05-15
2808 The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock
Sedore, C. A.; Segerdell, E.; Coleman-Hulbert, A. L.; Johnson, E.; Levi, J. N.; Lithgow, G. J.; Driscoll, M.; Phillips, P. C.
10.1101/2025.05.11.653363 — physiology — Posted on 2025-05-15
2809 The Dynamics of Inducible Genetic Circuits
Yang, Z.; Rousseau, R. J.; Mahdavi, S. D.; Garcia, H. G.; Phillips, R.
10.1101/2025.05.11.653320 — biophysics — Posted on 2025-05-15
2810 Sewing the future of cotton: a multi-omics study combining nanomechanics, transcriptomics, and phenotypic traits
Hasib, M. H. H.; Masud, N.; Biswas, A.; Jubery, T. Z.; Stanley, C.; Swaminathan, S.; Grover, C. E.; Wendel, J. F.; Sarkar, S.; Zabotina, O. A.; Sarkar, A.
10.1101/2025.05.12.653486 — biophysics — Posted on 2025-05-15
2812 TRPM8 protein dynamics correlates with ligand structure and cellular function
Mebrat, M. D.; Luu, D. D.; Hilton, J. K.; Kim, M.; Parrott, K.; Cherry, B. R.; Levitus, M.; Journigan, V. B.; Van Horn, W. D.
10.1101/2025.05.13.653789 — biophysics — Posted on 2025-05-15
2813 The Kink-Turn Motif: A Powerful Test for Revealing Weaknesses in RNA Force Fields
Lemmens, T.; Mlynsky, V.; Sponer, J.; Pykal, M.; Banas, P.; Otyepka, M.; Krepl, M.
10.1101/2025.05.13.653794 — biophysics — Posted on 2025-05-15
2814 High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface Antigens
Kothiwal, D.; Kollasch, A. W.; Hollmer, N.; Ghosh, A.; Zhang, R.; Anuganti, M.; Paul, S. B.; Zagar, Y.; Abdollahi, M.; Anderson, Z.; Belay, F.; Salotto, M.; Ulmer, S.; AbdelAlim, Y. A.; Kumar, S.; Vangala, M.; Yang, C.; Chedotal, A.; Jardine, J. G.; Teixeira, A. A. R.; Moshinsky, D. J.; Zhu, H.; Zhu, S.; Springer, T. A.; Marks, D. S.; Meijers, R.
10.1101/2025.05.15.650607 — biophysics — Posted on 2025-05-15
2815 Extracellular Matrix Physical Properties Regulate Cancer Cell Morphological Transitions in 3D Hydrogel Microtissues
Pourmostafa, A.; Uskach, G.; Jafari, M.; Yogeshwaran, S.; Wood, T. L.; Alisafaei, F.; Miri, A. K.
10.1101/2025.05.10.653220 — biophysics — Posted on 2025-05-15
2818 ERGA-BGE genome of Coenonympha oedippus: an IUCN endangered European butterfly species occurring in two ecotypes
Celik, T.; Lokovsek, T.; Buzan, E.; Boehne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Gut, M.; Aguilera, L.; Camara Ferreira, F.; Cruz Rodriguez, F.; Gomez-Garrido, J.; Alioto, T. S.; Haggerty, L.; Martin, F.; Bortoluzzi, C.
10.1101/2025.02.10.637396 — genomics — Posted on 2025-05-15
2819 ERGA-BGE genome of Cheirolophus tagananensis: an IUCN endangered shrub endemic to the Canary Islands
Pellicer, J.; Garnatje, T.; Vitales, D.; Hidalgo, O.; Valles, J.; Garcia-Fernandez, A.; Santos-Guerra, A.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory Team, ; Wellcome Sanger Institute Scientific Operations: Sequencing Operations, ; Wellcome Sanger Institute Tree of Life Core Informatics Team, ; Thomas, A.; Jackson, B.; Wood, J. M.; Howe, K.; Blaxter, M.; McCarthy, S.; Enriquez, V. P. B.; Haggerty, L.; Martin, F.; Bortoluzzi, C.
10.1101/2025.01.24.634661 — genomics — Posted on 2025-05-15
2820 Sex differences in DNA methylation in bats
Rayner, J. G.; Bock, S. L.; Lonski, A. J.; Riddle, N. C.; Wilkinson, G. S.
10.1101/2025.05.13.653776 — evolutionary biology — Posted on 2025-05-15
2822 Spatiotemporal diversification of forest understorey species reveals the existence of multiple Pleistocene forest refugia in Central Europe
Voisin, C.; Kirschner, P.; Zaveska, E.; Frajman, B.; Huelber, K.; Wessely, J.; Willner, W.; Schoenswetter, P.; Carnicero, P.
10.1101/2025.05.13.653645 — evolutionary biology — Posted on 2025-05-15
2823 The role of cytonuclear interactions to plant adaptation across a Populus hybrid zone
Zavala-Paez, M.; Sutara, B.; Keller, S.; Holliday, J.; Fitzpatrick, M.; Hamilton, J.
10.1101/2025.05.13.653687 — evolutionary biology — Posted on 2025-05-15
2824 Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids
Suzuki, H. C.; Saito, C. T.; Rajshekar, S.; Sokabe, T.; Haji, D.; Groen, S. C.; Pelaez, J. N.; Matsunaga, T.; Takemoto, A. S.; Tanaka, K. M.; Takahashi, A.; Tominaga, M.; Saito, S.; Whiteman, N. K.
10.1101/2025.05.09.653172 — evolutionary biology — Posted on 2025-05-15
2825 Advancing the design of the kissing bug kill trap for surveillance of triatomines
Tian, Y.; Fernandez-Santos, N. A.; Juarez, J. G.; Esquivel, H.; Moller-Vasquez, A. M.; Granados-Presa, M.; Echeverria, A.; Pennington, P. M.; Fimbres-Macias, J. P.; Roachell, W.; Lenhart, P.; Casey, T.; Keck, M. E.; Hodo, C. L.; Downs, C. H.; Sittenauer, S. C.; Nevins, C.; Balasubramanian, S.; Angulo, C.; Palacios-Cardiel, C.; Gaxiola-Robles, R.; Zenteno-Savin, T.; Hamer, S. A.; Borden, J. H.; Banfield, M. G.; Padilla, N.; Hamer, G. L.
10.1101/2025.05.09.653139 — ecology — Posted on 2025-05-15
2827 Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production
Bekendam, R. H.; Camacho, V.; Stone, A. P.; Barrachina, M. N.; Branfield, S.; Carminita, E.; Becker, I. C.; Lee, D. H.; Walsey, E.; Kaplan, J.; Payne, C.; Tilburg, J.; Pal, S.; Batista, L. F. Z.; Italiano, J. E.; Machlus, K. R.
10.1101/2025.05.08.652525 — cell biology — Posted on 2025-05-15
2829 Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood
Khateb, M.; Jung, R.; Leibou, S.; Hadley, P.; Yu, Z.; Dinerman, A. J.; Dulemba, V.; Gasmi, B.; Levin, N.; Kim, P.; Bhasin, A.; Bhat, D.; Sindiri, S.; Gartner, J. J.; Prickett, T. D.; Benzine, T.; Farid, S. S.; Parkhurst, M. R.; Halas, H.; Cao, Y.; Zhao, K.; Yang, J. C.; Robbins, P. F.; Lowery, F.; Krishna, S.; Heller, T.; McVicar, D.; Rosenberg, S. A.; Klemen, N. D.
10.1101/2025.05.11.653315 — immunology — Posted on 2025-05-15
2832 Human gloss perception reproduced by tiny neural networks
Morimoto, T.; Akbarinia, A.; Storrs, K. R.; Cheeseman, J. R.; Smithson, H. E.; Gegenfurtner, K. R.; Fleming, R. W.
10.1101/2025.05.09.653112 — neuroscience — Posted on 2025-05-15
2833 Large Language Models Reveal the Neural Tracking of Linguistic Context in Attended and Unattended Multi-Talker Speech
Puffay, C.; Mischler, G.; Choudhari, V.; Vanthornhout, J.; Bickel, S.; Mehta, A. D.; Schevon, C. A.; McKhann, G. M.; Van hamme, H.; Francart, T.; Mesgarani, N.
10.1101/2025.04.24.648897 — neuroscience — Posted on 2025-05-15
2838 Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach
Schwartz, S.; Engstler, C.; Muehlbauer, S.; Windenbach, E.; Wunder, T.; Kunz, H.-H.; Brandt, B.
10.1101/2025.05.15.654187 — plant biology — Posted on 2025-05-15
2840 Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product
Jagannathan, N. S.; Sin, W.-X.; Teo, D. B. L.; Kairi, F.; Luah, Y. H.; Lim, F. L. W. I.; Seng, M. S.-F.; Soh, S. Y.; Lee, Y. H.; Tucker-Kellogg, L.; Birnbaum, M. E.; Ram, R. J.
10.1101/2025.05.11.653250 — cancer biology — Posted on 2025-05-15
2841 Carbon-phosphorous exchange rate constrains growth of arbuscular mycorrhizal fungal networks
Bisot, C.; Galvez, L. O.; Kahane, F.; van Son, M.; Turcu, B.; Broekman, R.; Lin, K.-K.; Botenbal, P.; Winter, M. K.; Kokkoris, V.; West, S. A.; Godin, C.; Kiers, E. T.; Shimizu, T. S.
10.1101/2025.05.12.653230 — biophysics — Posted on 2025-05-15
2843 Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors
Merz, M. L.; Kailass, K.; Pergu, R.; Tran, K.; Gupta, K.; Severance, Z. C.; Singh, S.; Vedagopuram, S.; Law, B. K.; Rosenblatt, G.; Dhaliwal, R.; Choudhary, A.
10.1101/2025.05.10.652755 — biochemistry — Posted on 2025-05-15
2844 Phosphorylation-inducing molecules for regulating dynamic cellular processes
Pergu, R.; Vedagopuram, S.; Kokkonda, P.; Lai, S.; Tiwari, P. K.; Singh, S.; Kawai, J.; Singha, S.; Tian, W.; Thimaradka, V.; Tran, K.; Choudhary, A.
10.1101/2025.05.10.652895 — biochemistry — Posted on 2025-05-15
2845 Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration
Chen, C.; Gao, T.-Y.; Yi, H.-W.; Zhang, Y.; Wang, T.; Lou, Z.-L.; Wei, T.-F.; Lu, Y.-B.; Li, T.; Tang, C.; Zhang, W.-P.
10.1101/2024.10.18.619025 — biochemistry — Posted on 2025-05-15
2846 ERGA-BGE genome of Noah's Ark shell (Arca noae Linnaeus, 1758), a Mediterranean bivalve species
Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Sequencing Team, G.; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Teodori, E.; Duprat, S.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Haggerty, L.; Martin, F.; Bortoluzzi, C.
10.1101/2025.02.10.632159 — genomics — Posted on 2025-05-15
2849 Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease (V2)
Chocarro, J.; Marana, S.; Espelosin, M.; Rico, A. J.; Ariznabarreta, G.; Lorenzo-Ramos, E.; Ilarduya, M. M.; Hernandez-Alcoceba, R.; Chillon, M.; Vila, M.; Kordower, J.; Schapira, A. H. V.; Garcia-Osta, A.; Cuadrado-Tejedor, M.; Lanciego, J. L.
10.1101/2025.05.09.653000 — neuroscience — Posted on 2025-05-15
2852 Ancient DNA reveals diverse community organizations in the 5th millennium BCE Carpathian Basin
Szecsenyi-Nagy, A.; Virag, C.; Jakab, K.; Rohland, N.; Ringbauer, H.; Anders, A.; Raczky, P.; Hajdu, T.; Kiss, K.; Szeniczey, T.; Evinger, S.; Keszi, T.; Virag, Z. M.; Cheronet, O.; Mallick, S.; Akbari, A.; Pinhasi, R.; Reich, D.; Siklosi, Z.; Szecsenyi-Nagy, A.
10.1101/2025.01.02.631136 — genomics — Posted on 2025-05-15
2853 Pangenome analysis provides insights into the evolution of mango (Mangifera spp.)
Li, J.; Michael, V. N.; Simpson, S. A.; Youngblood, R. C.; Scheffler, B. E.; Crane, J. H.; Chen, S.; Hulse-Kemp, A. M.; Wu, X.
10.1101/2025.05.09.653124 — genomics — Posted on 2025-05-15
2858 Cryptococcus displays spore-specific invasion of alveolar epithelial cells
Ortiz, S. C.; Fortune-Grant, R.; Thom, A. J.; Davies, J.; May, R. C.; Drummond, R. A.; Bertuzzi, M.
10.1101/2023.12.14.571430 — microbiology — Posted on 2025-05-15
2860 Unveiling potato cultivars with microbiome interactive traits for sustainable agricultural production
Zhao, T.; Vink, S. N.; Jia, X.; Erban, A.; Schaarschmidt, S.; Kopka, J.; Zuther, E.; Treder, K.; Michalowska, D.; Guyoneaud, R.; Elzenga, J. T. M.; Attard, E.; Falcao Salles, J.
10.1101/2024.08.21.609084 — microbiology — Posted on 2025-05-15
2861 Affinity-matured CD72-targeting Nanobody CAR T-cells Enhance Elimination of Antigen-Low B-cell Malignancies
Izgutdina, A.; Rashid, T.; Temple, W. C.; Patino-Escobar, B.; Walunj, S.; Geng, H.; Takamatsu, H.; Gil-Alos, D.; Kang, A. S.; Ramos, E.; Chen, S.-Y.; Johnson, H.; Nix, M. A.; Naik, A.; Yuan, C. M.; Wang, H.-W.; Aminov, S.; Sahu, S.; Larson, R. C.; Carpenter, C.; Salangsang, F.; Phojanakong, P.; Camara Serrano, J. A.; Tariq, I.; Zakraoui, O.; Steri, V.; Valeri, A.; Martinez-Lopez, J.; Maus, M. V.; Parekh, S.; Verma, A.; Shah, N. N.; Wiita, A.
10.1101/2025.05.09.653155 — immunology — Posted on 2025-05-15
2862 Newly discovered and conserved role of IgM against viral infection in an early vertebrate
Kong, W.; Wang, X.; Ding, G.; Yang, P.; Shi, Y.; Cai, C.; Yang, X.; Cheng, G.; Takizawa, F.; XU, Z.
10.1101/2024.11.11.622905 — immunology — Posted on 2025-05-15
2864 Respiratory vocal coordination increases as zebra finches prepare to sing
Kizhakoot, D. B.; Kalra, S.; PR, R.; Chorol, S.; Chitnis, S.; Rao, D.; Rajan, R.
10.1101/2025.05.14.654126 — neuroscience — Posted on 2025-05-15
2866 No Effect of Chronic or Acute Pain on Working Memory in the Sternberg Task
Phelps, C. E.; Oliveira, L. E.; Ngo, M. N.; Medhi, K. S.; Schoone, S.; Debrosse, D.; Aragundi, L.; Delval, A. G. R.; Wilson, R. C.
10.1101/2025.05.13.653893 — neuroscience — Posted on 2025-05-15
2869 Unraveling Network Dynamics via Riemannian Multi-Scale Decomposition
Kleerekoper, Y.; Kurtam, M.; Keselman, Y.; Ghanayim, A.; Schiller, J.; Musall, S.; Sciller, Y.; Benisty, H.
10.1101/2025.03.26.645425 — neuroscience — Posted on 2025-05-15
2870 A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.
Marella, S.; Bogle, R.; Fox, J.; Tsoi, L. C.; Xing, X.; Gu, Y.; Kirma, J.; Sarkar, M. K.; van Drongelen, V.; Klein, B.; Kozlow, J. H.; Harms, P.; Gallagher, K.; Naik, S.; Rebecca, V. W.; Andersen, B.; Nakamura, M.; Kahlenberg, J. M.; Modlin, R. L.; Billi, A. C.; Gudjonsson, J. E.
10.1101/2025.05.10.653184 — systems biology — Posted on 2025-05-15
2872 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer
Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Li, Y.; Zhang, X.
10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-05-15
2875 A genome-wide, machine learning-guided exploration of the cis-regulatory code involved in neuronal differentiation
Cassan, O.; Raynal, J.; Vroland, C.; Yasuzawa, K.; Kouno, T.; Chang, J.-C.; Hon, C.-C.; Shin, J. W.; Kato, M.; Takahashi, H.; Kasukawa, T.; Nobusada, T.; Lagani, V.; Lehmann, R.; Yauy, K.; Carninci, P.; Yip, C. W.; Brehelin, L.; Lecellier, C. H.
10.1101/2025.05.14.653995 — bioinformatics — Posted on 2025-05-15
2876 FERMO: a Dashboard for Automated Prioritization of Molecular Features from Mass Spectral Data
Zdouc, M. M.; Augustijn, H. E.; Machushynets, N. V.; Bayona, L. M.; Soldatou, S.; de Jonge, N. F.; Casu, S.; Jaspars, M.; van Wezel, G. P.; Medema, M. H.; van der Hooft, J. J. J.
10.1101/2022.12.21.521422 — bioinformatics — Posted on 2025-05-15
2877 TCRanalyzer: A user-friendly tool for comprehensive analysis of T-cell diversity, dynamics and potential antigen targets
Seifert, N.; Reinke, S.; Kurz, N. S.; Demmer, J.; Kornrumpf, K.; Beissbarth, T.; Klapper, W.; Altenbuchinger, M.
10.1101/2025.05.09.652820 — bioinformatics — Posted on 2025-05-15
2878 Harmonizing single cell 3D genome data with STARK and scNucleome
Wen-Jie, J.; Kangwen, C.; Yuanchen, S.; An, L.; Hanwen, Z.; Ruixiang, G.; Chunge, Z.; Nana, W.; Futing, L.; Ten, F.; Yu-Juan, W.; Xiaoqi, Z.; Ming, X.; Hua-Jun, W.
10.1101/2025.05.10.653247 — bioinformatics — Posted on 2025-05-15
2879 A complete map of human cytosolic degrons and their relevance for disease
Voutsinos, V.; Johansson, K. E.; Larsen, F. B.; Gronbaek-Thygesen, M.; Jonsson, N.; Holm-Olesen, E.; Tesei, G.; Stein, A.; Fowler, D. M.; Lindorff-Larsen, K.; Hartmann-Petersen, R.
10.1101/2025.05.10.653233 — biochemistry — Posted on 2025-05-15
2882 FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets
Parekh, P.; Parker, N.; Pecheva, D.; Frei, E.; Vaudel, M.; Smith, D. M.; Rigby, A.; Jahołkowski, P.; Sonderby, I. E.; Birkenaes, V.; Bakken, N. R.; Fan, C. C.; Makowski, C.; Kopal, J.; Loughnan, R. J.; Hagler, D. J.; van der Meer, D.; Johansson, S.; Njolstad, P. R.; Jernigan, T. L.; Thompson, W. K.; Frei, O.; Shadrin, A. A.; Nichols, T. E.; Andreassen, O. A.; Dale, A. M.
10.1101/2025.05.09.653146 — genetics — Posted on 2025-05-15
2883 Prediction of mosquito vector abundance for three species in the Anopheles gambiae complex
Hosack, G. R.; El-Hachem, M.; Ickowicz, A.; Beeton, N. J.; Wilkins, A.; Hayes, K. R.; Rund, S. S. C.; Kelly, S. A.; McDowell, M. A.
10.1101/2025.03.04.641552 — ecology — Posted on 2025-05-15
2884 HOXA10-TWIST2 Antagonism Drives Partial Epithelial-to-Mesenchymal transition for Embryo Implantation
Ashary, N. S.; Suresh, S.; Bhide, A.; Shyamal, S.; N, P.; Mishra, A.; Patil, S.; A, A.; Hansda, S.; BV, H.; Jolly, M. K.; Modi, D.
10.1101/2025.01.10.631632 — developmental biology — Posted on 2025-05-15
2889 Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos
Li, X.; Huebner, R. J.; Williams, M. L. K.; Sawyer, J.; Peifer, M.; Wallingford, J. B.; Thirumalai, D.
10.1101/2024.07.11.603175 — biophysics — Posted on 2025-05-15
2890 Selective Knockout of Murine Glutamic Acid-rich Protein 2 (GARP2) Significantly Alters Cellular Dark Noise in Rod Photoreceptors
Stacks, D.; Bocchero, U.; DeRamus, M. L.; Nguyen, M.; Messinger, J.; Kraft, T. W.; Pittler, S. J.; Pahlberg, J.
10.1101/2025.05.09.653122 — neuroscience — Posted on 2025-05-14
2892 Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice
Layne, J. E.; Snapper, D. M.; Czachor, M. E.; Lam, C.; Matityahu, J. D.; Lind, D. R. G.; Huard, M.; Morioka, K.; Motzkin, J. C.; Basbaum, A. I.; Weinrich, J. A. P.; Bahney, C. S.
10.1101/2025.05.09.652892 — animal behavior and cognition — Posted on 2025-05-14
2894 Thyroid hormone promotes fetal neurogenesis
Salas-Lucia, F.; Escamilla, S.; Charest, A.; Jiang, H.; Stout, R.; Bianco, A. C.
10.1101/2025.05.14.654075 — neuroscience — Posted on 2025-05-14
2895 DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change
Pravata, M. V.; Forero, A.; Ayo Martin, A. C.; Berto, G.; Heymann, T.; Fast, L.; Mann, M.; Riesenberg, S.; Cappello, S.
10.1101/2025.05.14.654031 — neuroscience — Posted on 2025-05-14
2897 Quantifying cortical maturational aspects during different vigilance states in preterm infants by advanced EEG analysis
Burlando, G.; Uccella, S.; Marazzotta, V.; Wang, S. H.; Palva, J. M.; Roascio, M.; Rossi, A.; Ramenghi, L. A.; Nobili, L.; Arnulfo, G.
10.1101/2025.05.14.653972 — neuroscience — Posted on 2025-05-14
2899 Phytoplankton and giant virus dynamics during different monsoon seasons, a fish kill, and a toxic bloom in a eutrophic mariculture area
Gajigan, A. P.; Apego, G. C. M. B.; Gianan, E. L. D.; Francisco, R. B.; Tai, J. J.; Benico, G. A.; Repollo, C. L. A.; Villanoy, C. L.; Yniguez, A. T.; Conaco, C.; Steward, G. F.
10.1101/2025.05.12.653504 — microbiology — Posted on 2025-05-14
2900 Habenula alterations in resting state functional connectivity among autistic individuals
Hampson, C. L.; Peraza, J. A.; Guerrero, L. M.; Bottenhorn, K. L.; Riedel, M. C.; Almuqhim, F.; Smith, D. D.; Schmarder, K. M.; Crooks, K. E.; Pintos Lobo, R.; Sutherland, M. T.; Musser, E. D.; Dai, Y.; Agarwal, R.; Saeed, F.; Laird, A. R.
10.1101/2025.05.14.653992 — neuroscience — Posted on 2025-05-14
2901 Frequency and Characterization of Rare Histologic Subtypes in Canine Invasive Urothelial Carcinoma
Corbett, M. P.; Elbadawy, M.; Woodward, A. P.; Cheville, J. C.; Wickham, H.; Nicholson, H.; Catucci, M.; Melvin, B. J.; Ahmed, B.; Zdyrski, C.; Oliveira, L. J.; Howerth, E. W.; Pawlak, A.; Fasina, O.; Mochel, J. P.; Allenspach, K.
10.1101/2025.05.13.651218 — pathology — Posted on 2025-05-14
2906 Atlas-scale metabolic activities inferred from single-cell and spatial transcriptomics
Armingol, E.; Ashcroft, J.; Mareckova, M.; Prete, M.; Lorenzi, V.; Icoresi Mazzeo, C.; Lee, J. T. H.; Moullet, M.; Bayraktar, O. A.; Becker, C.; Zondervan, K.; Garcia-Alonso, L.; Lewis, N. E.; Vento-Tormo, R.
10.1101/2025.05.09.653038 — bioinformatics — Posted on 2025-05-14
2907 SANTON: Sequencing Analysis Toolkits for Off-target Nomination
Qiu, H.; Wang, R.; Wang, S.; Mulbagal, A. M.; Anderson, E.; Ge, H. G.
10.1101/2025.05.09.653082 — bioinformatics — Posted on 2025-05-14
2908 Establishment of chicken muscle and adipogenic cell cultures for cultivated meat production
Haach, V.; Silveira, K. R. D.; Peixoto, M. A.; Sa, A. P. P.; Gressler, V.; Feddern, V.; Ibelli, A. M. G.; Silva, L. P.; Bastos, A. P.
10.1101/2025.05.09.652510 — bioengineering — Posted on 2025-05-14
2909 DnaB and DciA: Mechanisms of Helicase Loading and Translocation on ssDNA
Gao, N.; Mazzoletti, D.; Peng, A.; Olinares, P. D. B.; Morrone, C.; Garavaglia, A.; Gouda, N.; Tsoy, S.; Mendoza, A.; Chowdhury, A.; Cerullo, A. R.; Bhavsar, H.; Rossi, F.; Rizzi, M.; Chait, B.; Miggiano, R.; Jeruzalmi, D.
10.1101/2024.11.09.622779 — biochemistry — Posted on 2025-05-14
2911 Characterization of a novel heat tolerance trait and subsequent haplotype block-based analysis to identify causal regions in Dutch Holstein cattle
Pook, T.; van Pelt, M. L.; Vandenplas, J.; Adriaens, I.; Zetouni, L.; Orrett, C.; de Haas, Y.; Kamphuis, C.; Gredler-Grandl, B.
10.1101/2025.05.02.651836 — genetics — Posted on 2025-05-14
2914 Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging
Ragle, J. M.; Pooranachithra, M.; Ashley, G. E.; Cadena, E.; Blank, B.; Kang, K.; Chen, C.; Bhowmick, A. R.; Mercado, S. H.; Wells, T. E.; Clancy, J. C. C.; Chisholm, A. D.; Ward, J. D.
10.1101/2025.05.14.653803 — developmental biology — Posted on 2025-05-14
2918 Chlamydia muridarum Infection Impacts Murine Models of Intestinal Inflammation and Cancer
Leung, G.; Carrasco, S. E.; Mourino, A. J.; Aydin, M.; Mammone, R.; Sonnenberg, G. F.; Diehl, G.; Artis, D.; Yano, H.; Arbona, R. J. R.; Lipman, N. S.
10.1101/2025.05.14.654029 — microbiology — Posted on 2025-05-14
2920 The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics
Velez, A. Z.; Radin, J. N.; Kennedy, E. N.; Parsons, J. B.; Tong, H. M.; Jung, E.; Alam, E.; Radlinski, L. C.; Wagner, N. J.; Fowler, V. G.; Rowe, S. E.; Kehl-Fie, T.; Conlon, B. P.
10.1101/2025.05.14.654040 — microbiology — Posted on 2025-05-14
2921 Nuclear trafficking of Anelloviridae capsid protein ORF1 reflects modular evolution of subcellular targeting signals
Petersen, G. F.; Pavan, S.; Ariawan, D.; Tietz, O.; Nematollahzadeh, S.; Sarker, S.; Forwood, J. K.; Alvisi, G.
10.1101/2025.05.14.653747 — microbiology — Posted on 2025-05-14
2923 Maternal and cross-stage effects of Metarhizium fungal infection on the malaria mosquito Anopheles coluzzii life-history
SARE, I.; VIANA, M.; MILLOGO, A.; LAMY, D. L.; TENETAO, A.; BADOLO, A.; DJIGMA, F.; DIABATE, A.; BALDINI, F.; BILGO, E.
10.1101/2025.05.14.654141 — microbiology — Posted on 2025-05-14
2925 IL-4 and TGF-β Regulate Inflammatory cytokines and Cellular Infiltration in the Lung in Mouse-adapted SARS-CoV-2 Infection
Sima, S. T.; Puebla-Clark, L.; Gonzalez-Orozco, M.; Endrino, M. J.; Shelite, T. R.; Tseng, H.-c.; Martinez-Martinez, Y. B.; Huante, M. B.; Federman, H. G.; Gbedande, K.; Menachery, V. D.; Siracusa, M. C.; Dann, S. M.; Endsley, J. J.; Rajsbaum, R.; Stephens, R.
10.1101/2025.05.13.653138 — immunology — Posted on 2025-05-14
2926 Nonsense-mediated decay controls a negative feedback loop in innate immune sensing
Boudreault, S.; Rivera-Lopez, Y.; Ferretti, M. B.; Bonner, J.; Jacobs, B.; Lynch, K. W.
10.1101/2025.05.09.652687 — immunology — Posted on 2025-05-14
2927 Growth charts of infant visual neurodevelopment generalize across global contexts
Margolis, E. T.; Camp, C.; Sobrino, A. C.; Polanczyk, G. V.; Fatori, D.; Khula South Africa Team, ; Germina Team, ; LABS Team, ; GABA Team, ; 1kD EEG Working Group, ; 1kD Machine Learning Working Group, ; Cornelissen, L.; Berde, C. B.; Hensch, T. K.; Nelson, C. A.; Shephard, E.; Donald, K. A.; Scheinost, D.; Gabard-Durnam, L. J.
10.1101/2025.03.25.645314 — neuroscience — Posted on 2025-05-14
2930 A Systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas
Chan, M.; Zhu, S.; Russell, Z.; Arora, S.; Arakaki, A.; Kumasaka, D.; Szulzewsky, F.; Michealraj, A.; Holland, E.; Gujral, T.
10.1101/2025.02.06.636949 — cancer biology — Posted on 2025-05-14
2932 Conformational dynamics of Paxillin and its multi-modal interaction with the Focal Adhesion Targeting Domain
Bhattacharya, S.; He, Y.; Chen, Y.; Mohanty, A.; Grishaev, A.; Kulkarni, P.; Salgia, R.; Orban, J.
10.1101/2025.01.01.630265 — biophysics — Posted on 2025-05-14
2933 FastConformation: A Standalone ML-Based Toolkit for Modeling and Analyzing Protein Conformational Ensembles at Scale
Galeazzi, F. M.; Monteiro da Silva, G.; Arantes, P. R.; Varghese, I.; Shukla, A.; Rubenstein, B. M.
10.1101/2025.05.09.653048 — biophysics — Posted on 2025-05-14
2936 Reducing Manual Labour in Forensic Microtrace Recognition with Deep Learning
Rijpkema, G.; Kalisvaart, D.; Korovin, S.; Spengler, D.; Pals, A.; van der Weerd, J.; Smith, C.
10.1101/2025.05.09.653056 — bioinformatics — Posted on 2025-05-14
2939 Megabase-scale human genome rearrangement with programmable bridge recombinases
Perry, N. T.; Bartie, L. J.; Katrekar, D.; Gonzalez, G. A.; Durrant, M. G.; Pai, J. J.; Fanton, A.; Hiraizumi, M.; Ricci-Tam, C.; Nishimasu, H.; Konermann, S.; Hsu, P. D.
10.1101/2025.05.14.653916 — bioengineering — Posted on 2025-05-14
2940 A Disease-Associated Mutation Impedes PPIA Through Allosteric Dynamics Modulation
Hattori, Y.; Kumashiro, M.; Kumeta, H.; Kyo, T.; Kawagoe, S.; Matsusaki, M.; Saio, T.
10.1101/2025.05.09.653011 — biochemistry — Posted on 2025-05-14
2945 CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging
Patino, A. V.; Chapman, H.; Ginzel, J. D.; Sills, J. E.; Lyerly, H. K.; Rogers, B. W.; Drut, J. E.; Snyder, J. C.
10.1101/2025.05.09.652935 — molecular biology — Posted on 2025-05-14
2947 A novel plasmid-mediated PAC β-lactamase (PAC-2) variant confers resistance to ceftazidime-avibactam in Klebsiella quasipneumoniae ST526, in Colombia.
Saavedra, S. Y.; Montilla-Escudero, E.; Ovalle, M. V.; Triana, J. A.; Torres, Y. S.; Vargas-Florez, N.; Gutierrez, M. A.; Barrera, A. F.; Duarte, C.
10.1101/2025.05.14.654127 — microbiology — Posted on 2025-05-14
2949 Cyclic di-AMP inhibits Listeria monocytogenes thymineless death during infection
Leeming, J. P.; Elkassih, O. M.; Oyebode, D. T.; Woodward, J. J.; Tang, Q.
10.1101/2025.05.14.654034 — microbiology — Posted on 2025-05-14
2950 Transposon activity eliminates a crucial fungal secondary metabolite cluster while preserving pathogenicity
Dijkstra, J.; van Westerhoven, A. C.; Li, Y.; Aguilera-Galvez, C.; Nakasato-Tagami, G.; Shi-Kunne, X.; Etalo, D. W.; Kema, G. H. J.
10.1101/2025.05.14.653967 — microbiology — Posted on 2025-05-14
2952 BONCAT-Live for isolation and cultivation of active environmental bacteria
Podar, M.; Mulay, S.; Vishnivetskaya, T. A.; Hochanadel, L.; Klingeman, D. M.; Lloyd, K. G.; Pelletier, D. A.
10.1101/2025.05.14.654084 — microbiology — Posted on 2025-05-14
2953 Peroxisomes regulate virulence and cell density sensing in Cryptococcus neoformans
Jacobs, E.; Dragotakes, Q.; dos Santos, S. R.; Smith, D. F.; Smith, B.; Wolf, J. M.; Coelho, C.; Casadevall, A.
10.1101/2025.05.14.654083 — microbiology — Posted on 2025-05-14
2954 Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism
Kamrad, S.; Mozzachiodi, S.; Blasche, S.; Aulakh, S. K.; Scheidweiler, D.; Basile, A.; Guan, R.; Bradley, R.; van den Berg, N. I.; Muelleder, M.; Ralser, M.; Patil, K. R.
10.1101/2025.05.14.653412 — microbiology — Posted on 2025-05-14
2955 Deep learning guided discovery of antibacterial polymeric nanoparticles
Wu, Y.; Wang, C.; Shen, X.; Chen, Y.; Wang, H.; Xu, B.; Chen, Y.; Dai, W.; Huang, Y.; Zou, L.; Ji, J.; Zhang, P.
10.1101/2025.05.13.653905 — microbiology — Posted on 2025-05-14
2956 Colonization with Oxalobacter formigenes slows the progression of CKD and reduces cardiac remodeling in CKD
Xiong, X.; Ho, M.; Jaber, K.; Mishra, R.; Charytan, A.; Zaidan, N.; Schlamp, F.; Fishman, G. I.; Nazzal, L.
10.1101/2025.05.14.654014 — microbiology — Posted on 2025-05-14
2957 HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells
Hwang, J. K.; Marston, D. J.; Tuyishime, M.; Yang, H.; Wrapp, D.; Li, D.; Brackenridge, S.; Frazier, M.; Rhodes, B.; Harris, C. M.; Quastel, M.; Kapingidza, A. B.; Kliszczak, A.; Gater, J.; Borrow, P.; Ferrari, G.; Gillespie, G. M.; McMichael, A. J.; Haynes, B. F.; Azoitei, M. L.
10.1101/2024.07.08.602401 — immunology — Posted on 2025-05-14
2958 β-Glucan Modulates Monocyte Plasticity and Differentiation Capacity to Mitigate DSS-Induced Colitis
Lv, Y.; Fan, Y.; Gao, Q.; Chen, Q.; Hu, Y.; Wang, L.; Shi, H.; Chen, E.; Xu, Q.; Cai, Y.; Fan, Q.; Li, L.; Du, D.; Ren, J.; Cheng, S.-C.; Xu, H.
10.1101/2025.05.09.653036 — immunology — Posted on 2025-05-14
2967 mRNArchitect: sequence design of mRNA medicines
Budzinska, M. A.; Zardbani, M.; Sidharta, M. P.; Waterhouse, J.; Leonard, T. E.; Ghodasara, A.; Lakshman Das, S.; Chang, R. Y.; Chaudhary, N.; Cheetham, S. W.; Mercer, T. R.; Gunter, H. M.
10.1101/2024.12.03.626696 — bioinformatics — Posted on 2025-05-14
2968 UniFORM: Towards Universal Immunofluorescence Normalization for Multiplex Tissue Imaging
Wang, K.; Ait-Ahmad, K.; Kupp, S.; Sims, Z.; Cramer, E.; Sayar, Z.; Yu, J.; Wong, M. H.; Mills, G. B.; Eksi, S. E.; Chang, Y. H.
10.1101/2024.12.06.626879 — bioinformatics — Posted on 2025-05-14
2969 Azapeptide-based GLP-1 receptor agonist improves glucose metabolism in a diet-induced obesity model
VanPatten, S.; He, M.; Cheng, K. F.; Al Jabari, B.; Brines, M.; Ballarin-Gonzalez, B.; Kruse, T.; Al-Abed, Y.
10.1101/2025.05.09.653092 — biochemistry — Posted on 2025-05-14
2970 Spatial epigenomic niches underlie glioblastoma cell state plasticity
Kint, S.; Younes, S. T.; Bao, S.; Long, G.; Wouters, D.; Stephenson, E.; Lou, X.; Zhong, M.; Zhang, D.; Su, G.; Enninful, A.; Yang, M.; Chen, H.-M.; Ellestad, K.; Anderson, C.; Moliterno, J.; Kelly, J.; Chan, J. A.; Sifrim, A.; Zhou, J.; Nikolic, A.; Fan, R.; Gallo, M.
10.1101/2025.05.09.653178 — genomics — Posted on 2025-05-14
2971 Cell-cycle-dependent repression of histone gene transcription by histone H4
Ahmad, K.; Wooten, M.; Takushi, B. N.; Vidaurre, V.; Chen, X.; Henikoff, S.
10.1101/2024.12.23.630206 — genomics — Posted on 2025-05-14
2975 Uridine cytidine kinases dictate the therapeutic response of molnupiravir via its bioactivation
Shu, H.; Sharma, S.; Alam, S.; Frank, L.; Tampere, M.; van Kuilenburg, A. B. P.; Valerie, N. C. K.; Altun, M.; Chabes, A.; Rudd, S. G.; Zhang, S. M.
10.1101/2025.05.13.653844 — microbiology — Posted on 2025-05-14
2976 Divergent Minimum Inhibitory Concentrations of Clarithromycin and Azithromycin Against Clinical Isolates of Mycobacterium abscessus Complex
Zhang, Y.; Xu, K.; Xu, P.; Cao, D.; Xiang, Y.; Dong, X.; Jiang, X.; Li, Y.; Yuan, X.; Qiu, Y.; Bi, K.; Zhang, Y.; Han, Y.
10.1101/2025.05.14.654039 — microbiology — Posted on 2025-05-14
2978 Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration
Pedraza, E.; R. Tejedor, A.; Feito, A.; Gamez, F.; Collepardo-Guevara, R.; Sanz, E.; R. Espinosa, J.
10.1101/2025.05.09.653068 — biophysics — Posted on 2025-05-14
2982 Generation and maintenance of apical rib-like actin fibers in epithelial support cells of the Drosophila eye
Bhattarai, A.; McGhie, E. W.; Woo, J. C.; Niraula, S.; Rosetti, P.; Kim, J. M.; Popoola, E.; Johnson, R.
10.1101/2025.05.09.653141 — developmental biology — Posted on 2025-05-14
2983 Lactate metabolism antagonizes antiviral innate immunity bypromoting VDAC1-lactylation-mediated mtDNA release
Wu, Y.; Li, L.; Liu, Y.; Wang, S.; Meng, F.; Li, T.; Xiao, H.; Wan, F.; Liu, Y.; Zhou, H.; Liu, C.; Zhang, Y.; Cao, J.
10.1101/2025.05.09.653027 — cell biology — Posted on 2025-05-14
2984 Differential Decay of Multiple eNA Components from a Cetacean
Brandao-Dias, P. F.; Shaffer, M.; Guri, G.; Parsons, K. M.; Kelly, R. P.; Allan, E. A.
10.1101/2025.05.09.653189 — molecular biology — Posted on 2025-05-14
2985 The gut microbiome of the Passalid beetle has high cellulolytic potential and constitutes an unrecognized system for production of greenhouse gasses in neotropical forests
Vargas, G.; Pinto-Tomas, A. A.; Murillo-Cruz, C.; Hernandez, M.; Dierick, D.; Hernandez, C.; Soto, S.; Chaves, I. Z.; Glavina del Rio, T.; Tringe, S. G.; Clardy, J.; Sherman, D. H.; Tamayo-Castillo, G.
10.1101/2025.05.12.653568 — microbiology — Posted on 2025-05-14
2987 Prognostically favorable immune responses to ovarian cancer are distinguished by self-reactive intra-epithelial plasma cells
Banville, A. C.; Laumont, C. M.; Singh, K.; Gladwin, B.; Dedora, J.; Mitchell, L.; Wang, J.; Miranda, A.; Mateyko, B.; Chavez, E. A.; Negri, G. L.; Cheng, S. W. G.; Smazynski, J.; Milne, K.; Wright, K.; Lampard, M.; Gierc, N.; Hamilton, P. T.; Spencer, S. E.; Kalaria, S.; Oostenbroek, T.; Negrea Puskas, V.; Steidl, C.; Morin, G. B.; Nathoo, F.; Nelson, B. H.
10.1101/2025.05.12.652297 — cancer biology — Posted on 2025-05-14
2988 A High-Dimensional Interfacial Wave Assay for Early Biophysical Profiling of Therapeutic Antibodies
St John, A. N.; Thomas, A. N.; Caramazza, P.; Meghdadi, A.; Bailey, J.; Lee, S.; Ramakrishna, V.; Amoruso, A. L. B.; Lam, E. S.-H.; Ganesh, N.; Shrivastava, S.
10.1101/2025.05.09.653084 — biophysics — Posted on 2025-05-14
2989 Genomic insights into the virulence repertoire and hemibiotrophic lifestyle of the grapevine black rot pathogen Phyllosticta ampelicida
Colombo, M.; Bettinelli, P.; Garcia, J.; Maddalena, G.; Toffolatti, S. L.; Hausmann, L.; Vezzulli, S.; Masiero, S.; Cantu, D.
10.1101/2025.05.08.652932 — genomics — Posted on 2025-05-14
2990 Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids
Suzuki, H. C.; Saito, C. T.; Rajshekar, S.; Sokabe, T.; Haji, D.; Groen, S. C.; Pelaez, J. N.; Matsunaga, T.; Takemoto, A. S.; Tanaka, K. M.; Takahashi, A.; Tominaga, M.; Saito, S.; Whiteman, N. K.
10.1101/2025.05.09.653172 — evolutionary biology — Posted on 2025-05-14
2992 Transcriptional changes in non-human primate tissues after intrathecal delivery of serotype 9 adeno-associated viral vector: insights into organ toxicities
Aihara, F.; Mardo, M.; Ruda, V.; Del Rio, T.; Bigot, K.; Singer, J.; Onishi-Seebacher, M.; Couttet, P.; Mansfield, K.; Hudry, E.
10.1101/2025.05.09.652903 — molecular biology — Posted on 2025-05-14
2993 Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface
Yin, O.; Almonte-Loya, A.; Appierdo, R.; Yang, M.; Yilmaz, B. D.; Oskotsky, T. T.; Gonzalez, J. M.; Giudice, L. C.; Afshar, Y.; Sirota, M.
10.1101/2025.05.09.653201 — molecular biology — Posted on 2025-05-14
2994 Phytoplankton and giant virus dynamics during different monsoon seasons, a fish kill, and a toxic bloom in a eutrophic mariculture area
Gajigan, A. P.; Apego, G. C. M. B.; Gianan, E. L. D.; Francisco, R. B.; Tai, J. J.; Benico, G. A.; Repollo, C. L. A.; Villanoy, C. L.; Yniguez, A. T.; Conaco, C.; Steward, G. F.
10.1101/2025.05.12.653504 — microbiology — Posted on 2025-05-14
2996 Improved Source Localization of Auditory Evoked Fields using Reciprocal BEM-FMM
Drumm, D. A.; Nunez Ponasso, G. C.; Linke, A.; Noetscher, G. M.; Maess, B.; Knösche, T. R.; Haueisen, J.; Lewine, J. D.; Abbott, C. C.; Makaroff, S. N.; Deng, Z.-D.
10.1101/2025.05.09.653081 — neuroscience — Posted on 2025-05-14
3005 A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies
Kong, Y.; Shi, J.; Wu, F.; Zhao, T.; Wang, R.; Zhu, X.; Xu, Q.; Song, Y.; Li, Q.; Wang, Y.; Gao, X.; Yang, Y.; Wu, Y.; Yang, Z.; Yao, J.; Ying, T.
10.1101/2025.05.09.653014 — bioinformatics — Posted on 2025-05-14
3006 Molecular biointerface characterisation for an implanted medical device using cryogenic orbitrap secondary ion mass spectrometry (Cryo-OrbiSIMS)
Sabri, A. H.; Wong, K. C.; Kotowska, A. M.; Fisher, L.; Luckett, J.; Mase, J. M.; Kammerling, L.; Figueredo, G.; Scurr, D. J.; Ghaemmaghami, A. M. M.; Alexander, M. R.
10.1101/2025.05.09.652996 — bioinformatics — Posted on 2025-05-14
3008 Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity
Neiswender, H.; Veeranan-Karmegam, R.; Pride, J. E.; Allen, P.; Neiswender, G.; Prabakar, A.; Hao, C.; Fan, X.; Gonsalvez, G.
10.1101/2025.05.13.653647 — cell biology — Posted on 2025-05-14
3009 PIN1 Drives Cellular Plasticity and Immune Modulation in Chronic Pancreatitis
Shah, V. M.; Bartlett, A.; Chen, C.; Matter, A.; Smith, A.; Zimny, H.; Wang, X.; Daniel, C.; Eng, J.; Youm, I.; Tsuda, M.; Calistri, N.; Reyer, M.; Morgan, T. K.; Dewson, G.; Waugh, T.; Keith, D.; Haverlack, S.; Xia, Z.; Chin, K.; Sheppard, B.; Brody, J.; Sears, R. C.
10.1101/2025.05.13.653850 — cell biology — Posted on 2025-05-14
3011 Meiotic prophase I disruption as a strategy for non-hormonal male contraception using small-molecule inhibitor JQ1
Simon, L. E.; Tanis, S.; Alexander, A. K.; Horan, T.; Carro, M. d. l. M.; Bonnett, S.-J.; Ben-Shlomo, R.; Xie, A.; Danko, C. G.; Lujic, J.; Cohen, P.
10.1101/2025.05.13.653822 — cell biology — Posted on 2025-05-14
3012 Bottom-up investigation of spatiotemporal glycocalyx dynamics with interferometric scattering microscopy
Brunner, C.; Pietsch, L.; vom Sondern, I.; Roehrl, M.; Popov, C.; Trollmann, M.; Taylor, R.; Blessing, M.; Holler, C.; Almahayni, K.; Jaeschke, S. O.; Sandoghdar, V.; Boeckmann, R. A.; Lindhorst, T.; Moeckl, L.
10.1101/2025.05.09.653034 — biophysics — Posted on 2025-05-14
3013 Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks
Malady, B.; Papagiannoula, A.; Kamatar, A.; Sarkar, S.; LeBrun, G. T.; Wang, L.; Hayden, C. C.; Lafer, E. M.; Owen, D. J.; Milles, S.; Stachowiak, J.
10.1101/2025.05.13.653742 — biophysics — Posted on 2025-05-14
3014 Nanoscale precise stamping of biomolecule patterns using DNA origami
Teodori, L.; Shahrokhtash, A.; Sorensen, E. A.; Zhang, X.; Malle, M. G.; Sutherland, D. S.; Kjems, J.
10.1101/2025.05.09.653003 — bioengineering — Posted on 2025-05-14
3015 DNA-binding and dimerization of the SOG1 NAC domain are functionally linked with its ability to undergo liquid-liquid phase separation
Mignon, K.; Van der Eecken, R.; Galle, M.; Demulder, M.; Van Lindt, J.; De Veylder, L.; De Greve, H.; Loris, R.
10.1101/2025.05.09.653017 — biochemistry — Posted on 2025-05-14
3019 CK1a-Mediated Two-Step Subunit Remodeling of the Circadian FRQ-FRH Complex
Schunke, C.; Ruppert, B.; Schultz, S.; Diernfellner, A. C. R.; Brunner, M.
10.1101/2025.05.13.653691 — cell biology — Posted on 2025-05-14
3020 Localizations and functions of septins are susceptible to epitope tagging
Gregory, J. R.; Llaneza, I. M.; Osmani, A. H.; Gosselin, H. E.; Wu, J.-Q.
10.1101/2025.05.13.653749 — cell biology — Posted on 2025-05-14
3024 Spatial control of secretory vesicle targeting by the Ync13-Rga7-Rng10 complex during cytokinesis
Zhang, S.; Singh, D.; Zhu, Y.-H.; Zhang, K. J.; Melero, A.; Martin, S. G.; Wu, J.-Q.
10.1101/2025.05.13.653810 — cell biology — Posted on 2025-05-14
3026 Adhirons are efficient tools to guide antiviral ligand discovery
Simmons, K. J.; Flynn, A. J.; Derry, A. E.; Debski-Antoniak, O.; muench, s. P.; Fontana, J.
10.1101/2025.05.13.653658 — cell biology — Posted on 2025-05-14
3028 Subcellular mass spectrometry imaging of lipids and nucleotides using transmission geometry ambient laser desorption and plasma ionisation
Young, R. S. E.; Piper, A.-K.; McAlary, L.; McKinnon, J. C.; Lum, J. S.; Soltwisch, J.; Niehaus, M.; Ellis, S. R.
10.1101/2025.05.13.653655 — cell biology — Posted on 2025-05-14
3030 Modulation of collagen-binding integrins affects fibroblast activation and inhibits fibrosis
Hamelmann, S.; Derakhshandeh, F.; Wagner, T.; Uebel, S.; Steigenberger, B.; Basquin, C.; Fabritz, S.; Schroeder-Braunstein, J.; Wabnitz, G.; Nakchbandi, I. A.
10.1101/2025.05.14.653428 — cell biology — Posted on 2025-05-14
3032 Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53
Jetishi, C.; Aeschlimann, S.; Schimanski, B.; Kaeser, S.; Mullner, R.; Oeljeklaus, S.; Akiyoshi, B.; Warscheid, B.; Butter, F.; Schneider, A.; Ochsenreiter, T.
10.1101/2025.05.14.653994 — cell biology — Posted on 2025-05-14
3033 Evaluating ultrastructural preservation quality in banked brain tissue
Garrood, M.; Keberle, A.; Sowa, A.; Janssen, W.; Thorn, E. L.; De Sanctis, C.; Farrell, K.; Crary, J. F.; McKenzie, A. T.
10.1101/2025.05.09.652503 — neuroscience — Posted on 2025-05-14
3037 Prenatal exposure to dietary levels of glyphosate disrupts metabolic, immune, and behavioral markers across generations in mice.
Barnett, J. A.; Josephson, J. K.; Haskey, N. A.; Hart, M. M.; Soma, K. K.; Verdugo, A.; McComb, C. J.; Bandy, M. L.; Ghosh, S.; Letef, C.; Copp, A.; Ishida, R.; Yuzbashian, E.; Gibon, J.; Ye, J.; Giebelhaus, R. T.; Murch, S. J.; Jung, M. M.; Gibson, D. L.
10.1101/2024.08.27.609990 — pharmacology and toxicology — Posted on 2025-05-14
3041 iModMix: Integrative Module Analysis for Multi-omics Data
Narvaez-Bandera, I. Y.; Lui, A.; Mekonnen, Y. A.; Rubio, V.; Sulman, N.; Wilson, C. M.; Ackerman, H.; Ospina, O.; Gonzalez-Calderon, G.; Flores, E.; Li, Q.; Chen, Y. A.; Fridley, B.; Stewart, P. A.
10.1101/2024.11.12.623208 — bioinformatics — Posted on 2025-05-14
3043 Enhanced protein precipitation with ammonia enables rapid, universal extraction of oligonucleotides for bioanalysis
Kamali, A.; Shelke, J. D.; Sanford, E. J.; Hayashi, M. M.; Chaisakhon, N.; Kolakowski, R. V.; Puri, S.; Zhang, G.
10.1101/2025.04.24.650521 — biochemistry — Posted on 2025-05-14
3044 Mapping nonhuman cultures with the Animal Culture Database
Basava, K.; Alam, M. N. U.; Roberts, L.; Martinet, K.; Cherry, P.; Garcia-Verdugo, H.; Roman-Palacios, C.
10.1101/2025.02.26.640400 — animal behavior and cognition — Posted on 2025-05-14
3046 FOSL2 regulates gonadotropin-dependent folliculogenesis through feedback amplification of FSH/FSHR signaling
Shi, H.; Chen, C.; Ran, Z.; Liao, J.; Wu, Z.; Wang, X.; Zhao, Y.; Ke, W.; Tan, B.; Liu, Y.; Su, Y.; Ren, W.; Li, X.; He, C.
10.1101/2025.03.11.642212 — cell biology — Posted on 2025-05-14
3048 Competition with Pseudomonas aeruginosa induces Staphylococcus aureus in an antibiotic-tolerant viable but non culturable state
Lapinska, U.; Chandran, G.; Tunstall, T.; Zborowsky, S.; Tolle, G.; Verderosa, A.; Garcia Castillo, M.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; Young, A. R.; Canton, R.; Caboni, P.; Blaskovich, M.; Warris, A.; Tsaneva-Atanasova, K.; Pagliara, S.
10.1101/2025.04.30.651255 — microbiology — Posted on 2025-05-14
3049 Systematic functional assessment of antiphage systems in their native host
David, E.; Plantady, C.; Poissonnier, S.; Elliott, J.; Kenck, E.; Le Boulch, J.; Gutierrez, A.; Chevallereau, A.
10.1101/2024.12.20.629700 — microbiology — Posted on 2025-05-14
3051 An open, fully-processed data resource for studying mood and sleep variability in the developing brain
Brook, J. B. H.; Salo, T.; Luo, A. C.; Bagautdinova, J.; Rush, S.; Alexander-Bloch, A. F.; Baller, E. B.; Calkins, M. E.; Cieslak, M.; Cooper, E. C.; Detre, J. A.; Elliot, M. A.; Fair, D. A.; Freedman, P.; Gehrman, P. R.; Gur, R. C.; Gur, R. E.; Klein, A.; Laney, N.; Laumann, T. O.; Mehta, K.; Merikangas, K.; Milham, M. P.; Mitchell, J. A.; Moore, T. M.; Nelson, S. M.; Ruparel, K.; Sevchik, B. L.; Shanmugan, S.; Shou, H.; Taso, M.; White, L. K.; Wolf, D. H.; Tisdall, D.; Roalf, D. R.; Satterthwaite, T. D.
10.1101/2025.05.01.651544 — neuroscience — Posted on 2025-05-14
3052 A simple method to efficiently generate structural variation in plants
Bechen, L. L.; Ahsan, N.; Bahrainwala, A.; Gehring, M.; Rajavasireddy, S.
10.1101/2024.12.20.629831 — plant biology — Posted on 2025-05-14
3054 Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes
Hamann, M. V.; Godbole, S.; Adiba, M.; Leddy, S.; Navolic, J.; Tabatabai, G.; Merk, D. J.; Lange, U. C.; Neumann, J. E.
10.1101/2025.05.13.653713 — cancer biology — Posted on 2025-05-14
3055 Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer
Kay, J. E.; Corrigan, J. J.; Volk, L. B.; Armijo, A. L.; Nazari, I. S.; Torous, D. K.; Avlasevich, S. L.; Croy, R. G.; Wadduwage, D. N.; Dertinger, S. D.; Essigmann, J. M.; Samson, L. D.; Carrasco, S. E.; Engelward, B. P.
10.1101/2025.05.13.653839 — cancer biology — Posted on 2025-05-14
3056 A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity
de Jong, G.; Memi, F.; Gracia, T.; Lazareva, O.; Gould, O.; Aivazidis, A.; Dave, M.; Zhang, Q.; Jensen, M.; Rifaioglu, A. S.; Barros-Silva, J. D.; Eckert, S.; Zhou, D.; Wood, Y.; Tuck, E.; Er, S.; Marshall, H.; Roberts, K.; Trinh, A. L.; Rai, S.; Shaw, T.; Oszlanczi, A.; Powell, H.; Petryszak, R.; Katsirea, Z.; Mamun, I.; Mulas, I.; Quaegebeur, A.; Briggs, M.; Makarchuk, S.; Cox, J.; Lee, J. T. H.; Rueda, L.; Saraswat, M.; Bulstrode, H.; Young, A.; Patel, M.; Porter, T.; Prigmore, E.; Mall, M.; Saez-Rodriguez, J.; Briscoe, J.; Rowitch, D. H.; Mair, R.; Behjati, S.; Stegle, O.; Bayraktar, O. A.
10.1101/2025.05.13.653495 — cancer biology — Posted on 2025-05-14
3057 Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML
Sinanidis, I.; Tsakiroglou, P.; Dubner, B.; Foertsch, R.; Gondek, J.; Choi, I.; Paun, B.; Zhao, L.; Ghiaur, G.; Dalton, W. B.
10.1101/2025.05.13.651470 — cancer biology — Posted on 2025-05-14
3058 SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.
Ortmann, B.; Bertlin, J. A. C.; Seear, R. V.; Arnaiz, E.; Lin, S.; Salman, A. M.; Wilson, L.; Harris, A. L.; Stewart, G. D.; Hepburn, A.; Clare, S.; Robson, C. N. N.; Speak, A. O.; Nathan, J. A.
10.1101/2025.05.13.653699 — cancer biology — Posted on 2025-05-14
3059 THE IMMUNE RESPONSE AGAINST CANCER IS MODULATED BY STROMAL CELL FIBRONECTIN
Lubosch, A.; Pitt, L.; Zoeller, C.; Wirth, F.; Exner, T.; Steigenberger, B.; Schroeder-Braunstein, J.; Wabnitz, G.; Nakchbandi, I. A.
10.1101/2025.05.14.653424 — cancer biology — Posted on 2025-05-14
3060 EZH2 alters aggressive variant prostate cancer subtype evolution, but is not required for neuroendocrine prostate cancer
Jacobi, J. J.; Wadosky, K. M.; Jaiswal, N.; Zhang, X.; Wang, Y.; Singh, P.; Wang, J.; Gomez, E. C.; Wang, J.; Xu, B.; Cejas, P.; Kukreja, S.; LONG, H. W.; Goodrich, D. W.
10.1101/2025.05.13.653549 — cancer biology — Posted on 2025-05-14
3061 Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect
Moon, E. J.; Vilaplana Lopera, N.; Kim, J.; Nam, G.; Tullis, I. D. C.; Paillas, S.; Ruan, J.-L.; Jiang, Y.; Park, S.; Lee, P. J.; Hou, T.; Walker, E.; Abu-Halawa, A.; Hill, M. A.; Choi, C.; Lee, I. J.; Jeong, Y.; Lakhal-Littleton, S.; Then, C. K.; Shen, S.-C.; Giaccia, A.; Petersson, K.
10.1101/2025.05.14.653978 — cancer biology — Posted on 2025-05-14
3064 Improving the monitoring of the invasive Blue Crab (Callinectes sapidus): combining environmental DNA and citizen observations
Delrieu-Trottin, E.; Bianic, M.; Miaud, C.; Garcia, M.; Arnal, V.; Hocde, R.; Cochet, C.; Barre, N.; Cornil, L.; Manel, S.
10.1101/2024.10.24.620022 — ecology — Posted on 2025-05-14
3065 Dogs gone wild: habitat use and ecological impacts of feral dogs in sub-Antarctic Chile
Tebelmann, H.; Kaefer, S.; Pages, A. S.; Ruiz, A. C.; Volkart, N. S.; Ganslosser, U.
10.1101/2025.05.08.652634 — ecology — Posted on 2025-05-14
3066 Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex
Francavilla, R.; Chattopadhyaya, B.; Damo Kamda, J. L.; Jadhav, V.; Kourrich, S.; Michaud, J. L.; Di Cristo, G.
10.1101/2024.02.27.582362 — neuroscience — Posted on 2025-05-14
3067 Blue light increases stomatal conductance and photosynthesis in Agave hybrid
Sartori, H. L.; Silva, S. J.; Cruz, L. P.; Laira, M. D.; Raya, F. T.; Pereira, G. A.; Ribeiro, R. V.
10.1101/2025.05.13.653724 — plant biology — Posted on 2025-05-14
3070 Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude
Hansen, A. S.; Mazzocca, M.; Narducci, D. N.; Grosse-Holz, S.; Matthias, J.
10.1101/2025.05.10.653248 — biophysics — Posted on 2025-05-14
3071 Individual heterogeneity drives a plant macroparasites life history
Spacey, O. G.; Jones, O. R.; Record, S.; Janssen, S. D.; Yue, A. Y.; Liu, W.; Rosen, A.; Thorogood, C. J.; Salguero-Gomez, R.
10.1101/2025.05.09.653086 — ecology — Posted on 2025-05-14
3072 Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease (V1)
Chocarro, J.; Marana, S.; Espelosin, M.; Rico, A. J.; Ariznabarreta, G.; Lorenzo-Ramos, E.; Illarduya, M. M.; Hernandez-Alcoceba, R.; Chillon, M.; Vila, M.; Kordower, J.; Schapira, A. H. V.; Garcia-Osta, A.; Cuadrado-Tejedor, M.; Lanciego, J. L.
10.1101/2025.05.09.653000 — neuroscience — Posted on 2025-05-14
3076 It's all in the timing: vegetative phase change alters selection under drought and contributes to local adaptation
Lawrence-Paul, E. H.; Janakiraman, J.; Lawrence-Paul, M. R.; Ben-Zeev, R.; Penn, A.; Lasky, J. R.
10.1101/2025.05.13.653704 — plant biology — Posted on 2025-05-14
3077 The HORMA-domain protein ASY1 recruits the plant-specific cyclin SDS to promote DMC1-mediated meiotic recombination
Cai, B.; Yuan, X.; Luo, Y.; Cao, F.; Zhang, Y.; Zhuang, J.; Geng, M.; Chu, L.; Schnittger, A.; Yang, C.
10.1101/2025.05.13.653901 — plant biology — Posted on 2025-05-14
3079 Multiplexed profiling of transcriptional regulators in plant cells
Alamos, S.; Waldburger, L.; Dee, A.; Owens, L.; Rattan, R.; Ong, S.; Shih, P.
10.1101/2025.05.12.653590 — plant biology — Posted on 2025-05-14
3081 Synergistic 3D, multispectral, and thermal image analysis via supervised machine learning for improved detection of root rot symptoms in hydroponically-grown flat-leaf parsley
Agarwal, A.; de Jesus Colwell, F.; Bello Rodriguez, J.; Sommer, S.; Barman, M.; Correa Galvis, V. A.; Hill, T. R.; Boonham, N.; Prashar, A.
10.1101/2025.05.14.653930 — plant biology — Posted on 2025-05-14
3083 SoftAlign: End-to-end protein structures alignment
Trinquier, J.; Petti, S.; Park, S.; Herath, K.; van Kempen, M.; Feng, S.; Söding, J.; Steinegger, M.; Ovchinnikov, S.
10.1101/2025.05.09.653096 — bioinformatics — Posted on 2025-05-14
3085 In situ profiling of plasma cell clonality with image-based single-cell transcriptomics
Yang, E.; Aceves-Salvador, J.; Castrillon, C.; Herrmann, U. S.; Akama-Garren, E. H.; Carroll, M. C.; Moffitt, J. R.
10.1101/2025.05.09.653118 — immunology — Posted on 2025-05-14
3087 Delayed forebrain excitatory and inhibitory neurogenesis inSTRADA-related megalencephaly via mTOR hyperactivity
Pan, T.; Lin, G.; Li, X.; VanHeyningen, D.; Walker, J. C.; Kohli, S.; Saravanan, A.; Amrita, A.; Jaklic, D. C.; Pantoja-Gutierrez, S.; Vaid, S.; Sturza, J.; Inoki, K.; Imamichi, T.; Chang, W.; Dang, L. T.
10.1101/2025.05.13.653911 — neuroscience — Posted on 2025-05-14
3091 Comparative analysis of CRISPR/Cas9-targeted nanopore sequencing approaches in repeat expansion disorders
Benarroch, L.; Boelle, P.-Y.; Madry, H.; Mohand Oumoussa, B.; Eura, N.; Nishino, I.; Labreche, K.; Gorbunova, V.; Bassez, G.; Stojkovic, T.; Gourdon, G.; Bonne, G.; Tome, S.
10.1101/2024.12.04.626786 — bioinformatics — Posted on 2025-05-14
3093 TidyMass2: Advancing LC-MS Untargeted Metabolomics Through Metabolite Origin Inference and Metabolic Feature-based Functional Module Analysis
Wang, X.; Liu, Y.; Jiang, C.; Huang, Z.; Yan, H.; Wong, S.; Johnson, C.; Zhang, J.; Ge, Y.; Zhang, F.; Lai, R.; Gao, P.; Zhang, X.; Shen, X.
10.1101/2025.05.09.652992 — bioinformatics — Posted on 2025-05-14
3095 HYDRA: Fabrication of cell culture HYDrogels by Robotic liquid handling Automation for high-throughput drug testing
Torchia, E.; Di Sante, M.; Horda, B.; Mihajlovic, M.; Zimmermann, J.; Pezzotti, M.; Cimetta, E.; Gabriele, S.; Auricchio, F.; Lind, J. U.; Enrico, A.; Pasqualini, F. S.
10.1101/2024.12.22.629679 — bioengineering — Posted on 2025-05-14
3096 Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly
Castelvecchi, G.; Li, L.; Shin, J.; Villarreal, N. L.; Roszko, I.; Gontarz, P.; Li, T.; Zhang, B.; Sepich, D.; Krezel, L. S.
10.1101/2025.05.10.653271 — developmental biology — Posted on 2025-05-14
3100 A novel pH-sensitive probe to quantify autophagy on high throughput/content imaging platforms
Ciccotosto, G. D.; Jana, M.; Galluzzi, L.; Mitchell, L.; Gupta, P.; Furness, S. G. B.; Lazarou, M.; Hare, D. L.; Wookey, P. J.
10.1101/2025.05.13.653902 — cell biology — Posted on 2025-05-14
3101 Non-redundant cardiolipin synthases shape membrane composition and support stress resilience in Bacteroides fragilis
Schnizlein, M. K.; Hong, B. J.; Nguyen, J. N. T.; Jones, K.; Rodriguez, A. I.; Fiebig, A.; Campagna, S. R.; Balunas, M. J.; O'Halloran, T. V.; Crosson, S.
10.1101/2025.05.12.653583 — microbiology — Posted on 2025-05-14
3103 Independent Generation of Amyloid-β via Novel APP Transcripts
Gustavsson, E. K.; Abel, E.; Macpherson, H.; Brinkmalm, G.; Piotrowska, D.; Wagen, A. Z.; Montgomery, K.; Villegas Llerena, C.; Alvarez Giovannucci, T.; de Silva, R.; Heslegrave, A.; Fox, N.; Zetterberg, H.; Houlden, H.; Hardy, J.; Wray, S.; Arber, C.; Ryten, M.
10.1101/2025.05.13.651054 — neuroscience — Posted on 2025-05-14
3104 Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models
Choudhary, A.; Rosh, I.; Hussein, Y.; Netser, S.; Suliman, T.; Shemen, A.; Rike, W. A.; Simchi, L.; Shklyar, B.; Abu-Akel, A.; Zinger, A.; Offen, D.; Wagner, S.; Stern, S.
10.1101/2024.08.27.609917 — neuroscience — Posted on 2025-05-14
3106 Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish
Hillman, C. S.; Petracco, G.; Fontana, B. D.; Scaia, M. F.; Dalla Vecchia, E.; Wetton, J. H.; Norton, W. H.; Parker, M. O.; Reichmann, F.
10.1101/2025.05.12.653402 — neuroscience — Posted on 2025-05-14
3112 McsB regulates CtsR thermosensing through periphery arginine phosphorylation
Cai, H.; Hua, B.; Hu, J.; Fu, Y.; Ding, X.; Duan, G.; Guo, Y.; Xia, X.-H.; Zhao, Y.
10.1101/2024.12.26.630380 — biophysics — Posted on 2025-05-14
3113 Self-driving development of perfusion processes for monoclonal antibody production
Mueller, C.; Vuillemin, T.; Gadiyar, C. J.; Souquet, J.; Bielser, J. M.; Fagnani, A.; Sokolov, M.; von Stosch, M.; Feidl, F.; Butte, A.; Cruz Bournazou, M. N.
10.1101/2024.09.03.610922 — bioengineering — Posted on 2025-05-14
3117 Single-Cell Metabolic Imaging Reveals Glycogen Driven-Adaptations in Endothelial Cells
Chadha, R. S.; Yang, B.; Yuan, D.; Kocheril, P. A.; Mahajan, S.; Colazo, A.; Malhi, N. K.; Ambarian, J. A.; Liu, X.; Chen, Z. B.; Wei, L.
10.1101/2025.05.11.653328 — cell biology — Posted on 2025-05-14
3118 HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A
Nguyen, N. G. T.; Sapkota, H.; Shibata, Y.; Fesiuk, A.; Antalek, M.; Sail, V.; Ansel, D. J.; Amici, D. R.; Peelor, F. F.; Van Remmen, H.; Miller, B. F.; Mendillo, M. L.; Morimoto, R. I.; Li, J.
10.1101/2025.05.12.653547 — cell biology — Posted on 2025-05-14
3120 Intensity Modulation of Trichromatic Split Fluorescent Proteins for Live Cell Mapping
Ishii, M.; Kinjo, T.; Kondo, Y.; Terai, K.; Aoki, K.; Kuhlman, B.; Matsuda, M.
10.1101/2025.05.13.653616 — cell biology — Posted on 2025-05-14
3122 Lipid Droplets are active translation depots that respond to infection
Jha, R. M.; Menon, D.; Nahak, A.; Kumar, A.; Choudhary, V.; Gandotra, S.
10.1101/2025.05.12.653387 — cell biology — Posted on 2025-05-14
3123 EVALUATION OF STAINING FOR FIBRONECTIN ISOFORMS IN LIVER DISEASES
Hamelmann, S.; Sarmiento, J.; Bung, T.; Menhem, M.; Cohen, A. J.; Gooch, G.; Thevenot, P.; Burshell, A.; Nakchbandi, I. A.
10.1101/2025.05.14.653452 — cell biology — Posted on 2025-05-14
3124 Receptor agonist of NFκB signaling ligand directs lung epithelial cell expansion through RANK signaling
Habibie, H.; Vlasma, J. R.; Putri, K.; Song, S.; Jager, M. d.; Petersen, A.; Boorsma, C. E.; Cool, R. H.; Quax, W.; Nawijn, M.; Timens, W.; Burgess, J. K.; Brandsma, C.-A.; Melgert, B. N.
10.1101/2025.05.13.648716 — cell biology — Posted on 2025-05-14
3125 Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia
Zhang, J.; Wu, W.; Wang, Y.; Zhang, Y.; Wang, Y.; Bai, W.; Zhang, Z.; Zhu, C.; Wu, Y.; Zhang, Z.; Yang, L.; Lei, H.; Xu, H.; Zhou, L.; Wu, Y.
10.1101/2025.05.11.653221 — cell biology — Posted on 2025-05-14
3136 Generative AI-driven artificial DNA design for enhancing inter-species gene activation and enzymatic degradation of PET
Akiyama, M.; Tashiro, M.; Huang, Y.; Uehara, M.; Kanzaki, T.; Itaya, M.; Kataoka, M.; Miyamoto, K.; Sakakibara, Y.
10.1101/2025.05.08.652991 — bioinformatics — Posted on 2025-05-14
3138 Vib2Sound: Separation of Multimodal Sound Sources
Akahoshi, M.; Wang, Y.; Cheng, L.; Zai, A. T.; Hahnloser, R. R. H.
10.1101/2025.05.08.652866 — animal behavior and cognition — Posted on 2025-05-14
3141 ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes
Nikopaschou, M.; Samiotaki, M.; Kannavou, A.; Angelis, N.; Tsitsilonis, O.; Panayotou, G.; Stratikos, E.
10.1101/2025.05.08.652898 — immunology — Posted on 2025-05-14
3142 Ultradeep N-glycoproteome Atlas of Mouse Reveals Spatiotemporal Signatures of Brain Aging and Neurodegenerative Diseases
Fang, P.; Yu, X.; ding, m.; Cong, Q.; Jiang, H.; Shi, Q.; Zhao, W.; Zheng, W.; Li, Y.; Ling, Z.; Kong, W.; Yang, P.; Shen, H.
10.1101/2025.02.15.638397 — neuroscience — Posted on 2025-05-14
3143 Low-Intensity Ultrasound Stimulates TAZ in Schwann cells
Acheta, J.; Haley, J.; Mondschein, A. S.; Lanka, M.; Belin, S.; Poitelon, y.
10.1101/2025.05.08.652925 — neuroscience — Posted on 2025-05-14
3144 Molecular pathology of acute spinal cord injury in middle-aged mice
Fehlberg, C.; John, D.; Kang, B.; Choi, J. S.; Cerqueira, S. R.; Brake, A.; Lee, J. K.
10.1101/2025.05.08.652873 — neuroscience — Posted on 2025-05-14
3147 Unbiased genetics identifies a glutamatergic signaling network as a mediator of daily sleep patterns.
Grizzard, S.; Lord, J. S.; Ravens, A. L.; Hao, Y.; Tang, W.; Lee, S. H.; Sleiman, S. J.; Joyce, K. K.; Donohue, K. D.; O'Hara, B. F.; Zou, F.; Kafri, T.; Diering, G. H.
10.1101/2025.05.08.652901 — neuroscience — Posted on 2025-05-14
3148 Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease
van der Vliet, D.; de Vries, L. E.; Di, X.; de Jong, B.; van der Meij, M. T. C.; van der Peet, M.; Harms, A. C.; Hankemeier, T.; Swaab, D. F.; Huitinga, I.; Verhaagen, J.; van der Stelt, M.
10.1101/2025.05.08.652735 — neuroscience — Posted on 2025-05-14
3153 Experimental flooding impacts soil biogeochemistry but not aboveground vegetation in a coastal forest
Regier, P.; Bond-Lamberty, B.; Ward, N. D.; Bailey, V.; Bittencourt Peixoto, R.; Machado-Silva, F.; McDowell, N.; Morris, K.; Myers-Pigg, A.; Pennington, S.; Rahman, M.; Rich, R.; Smith, R.; Wilson, S. J.; Woodard, S.; Stearns, A.; Day, D.; Doro, K. O.; Emmanuel, E.; Ogunsola, O.; Patel, K.; Megonigal, J. P.
10.1101/2025.05.09.653188 — systems biology — Posted on 2025-05-14
3155 Longitudinal study of liver disease progression in the PEX1-Gly844Asp mouse model of mild Zellweger Spectrum Disorder
Chen, L.; Choi, H.; Argyriou, C.; Hsieh, M.; Di Pietro, E.; Cui, W.; Nuebel, E.; Daneault, C.; Ruiz, M.; Charpentier, D.; Rhainds, D.; Hacia, J. G.; Nguyen, V.-H.; Gao, Z.; Braverman, N.
10.1101/2025.05.08.652960 — pathology — Posted on 2025-05-14
3156 Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis
Wu, S.; Driver, I.; Luo, M.; Miyazaki, H.; Shambhu, S.; Popov, D.; Yang, L.; Wang, J.; Ma, J.; Guo, J.; Atha, J.; Tata, A.; Hoffman, E.; Wang, Y.; Tata, P.; Jensen, M. B.; Engelhardt, J. F.; Sontake, V.; Liu, X.
10.1101/2025.05.08.652970 — pathology — Posted on 2025-05-14
3157 LivecellX: A Deep-learning-based, Single-Cell Object-Oriented Framework for Quantitative Analysis in Live-Cell Imaging
Ni, K.; Yu, G.; Zheng, Z.; Lu, Y.; Poe, D.; Zhang, S.; Wang, Z.; Khurana, Y.; Lu, Y.; Chen, Y.; Zhou, S.; Sanborn, M.; Wang, W.; Xing, J.
10.1101/2025.02.23.639532 — biophysics — Posted on 2025-05-14
3158 DynaMiCs - Dynamic cell-type deconvolution ensembles for Mapping in mixed Conditions
Seifert, N.; Engel, L.; Tauschke, J.; Sterr, T.; Demmer, J.; Mensching-Buhr, M.; Voelkl, D.; Grellscheid, S. N.; Beissbarth, T.; Goertler, F.; Zacharias, H.; Altenbuchinger, M.
10.1101/2025.05.08.652868 — bioinformatics — Posted on 2025-05-14
3162 Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge
Zhang, Z.; Bao, X.; Jiang, L.; Luo, X.; Wang, Y.; Comai, A.; Waldhaus, J.; Hansen, A. S.; Li, W.; Liu, J.
10.1101/2025.05.08.652986 — bioinformatics — Posted on 2025-05-14
3164 Venom vesicles from the parasitoid Ganaspis hookeri facilitate venom protein entry into host immune cells
Bretz, N. M.; Lark, C.; Perkel, S.; Jackson, R.; Driskell, J. D.; Mobley, J. A.; Mortimer, N. T.
10.1101/2025.05.08.652939 — biochemistry — Posted on 2025-05-14
3166 Pnrc2 promotes rapid mRNA decay and coordinately supports early development with P-body factors Ddx6 and Ddx61
Gallagher, T. L.; Blatnik, M. C.; Austin, C. C.; Thompson, K. G.; Pvirre, D. M.; Morgan, A.; Kearse, M. G.; Amacher, S. L.
10.1101/2025.05.08.652725 — developmental biology — Posted on 2025-05-14
3169 AI4CellFate: Interpretable Early Cell Fate Prediction with Generative AI
Cunha, I.; Panconi, L.; Bauer, S.; Gestin, M.; Latron, E.; Sahai, E.; Le Marois, A.; Griffie, J.
10.1101/2025.05.12.653464 — bioinformatics — Posted on 2025-05-14
3170 Genetic basis of immunity in Indian cattle as revealed by comparative analysis of Bos genome
Thambiraja, M.; Iyengar, S. K.; Sathishkumar, B.; Kavuru, S. R.; Katari, A.; Singh, D.; Onteru, S. K.; Yennamalli, R. M.
10.1101/2024.12.09.627532 — bioinformatics — Posted on 2025-05-14
3172 Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells
Banerjee, S.; Shende, S.; Kata, L.; Lopes, R.; Praveen, S.; Joshi, R.; Khare, N. K.; Raghuram, G. V.; Shabrish, S.; Mittra, I.
10.1101/2023.11.21.567988 — evolutionary biology — Posted on 2025-05-14
3173 Host genotype and sex shape influenza evolution and defective viral genomes
Costa, R. M.; Alvarez-Acosta, L.; Curtis, K.; Kelleher, J.; Lamichhane, B. S.; Valesano, A. L.; Fitzsimmons, W. J.; Lauring, A. S.; Seger, J.; Adler, F. R.; Potts, W. K.
10.1101/2025.02.26.638946 — evolutionary biology — Posted on 2025-05-14
3177 A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
Rühling, M.; Schmelz, F.; Ulbrich, K.; Schumacher, F.; Wolf, J.; Pfefferle, M.; Priester, M.; Moldovan, A.; Knoch, N.; Iwanowitsch, A.; Kappe, C.; Paprotka, K.; Kleuser, B.; Arenz, C.; Fraunholz, M. J.
10.1101/2024.09.13.612871 — microbiology — Posted on 2025-05-14
3178 Tissue-specific improvements in CD4+ T cell responses after treatment for visceral leishmaniasis.
Engel, J. A.; Rivera, F.; Crawford, B.; Lee, H. J.; Na, J.; Chang, K.; Gartlan, K.; Bukali, L.; Frame, T.; Wang, Y.; Haque, A.; Engwerda, C.; Engwerda, C.
10.1101/2025.04.13.648617 — immunology — Posted on 2025-05-14
3179 Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.
CHIE, J. A. K. H. C.; PERSOHN, S. A.; PANDEY, R. S.; SIMCOX, O. R.; SALAMA, P.; TERRITO, P. R.
10.1101/2025.05.12.653558 — neuroscience — Posted on 2025-05-14
3182 Frontal Theta Oscillations and Cognitive Flexibility: Age-Related Modulations in EEG Activity
Darna, M.; Stolz, C.; Jauch, H. S.; Strumpf, H.; Hopf, J. M.; Seidenbecher, C. I.; Schott, B. H.; Richter, A.
10.1101/2024.07.05.602082 — neuroscience — Posted on 2025-05-14
3183 Why is there so much variability in crop multi-model studies?
Wallach, D.; Palosuo, T.; Mielenz, H.; Buis, S.; Thorburn, P.; Asseng, S.; Dumont, B.; Ferrise, R.; Gayler, S.; Ghahramani, A.; Harrison, M. T.; Hochman, Z.; Hoogenboom, G.; Huang, M.; Jing, Q.; Justes, E.; Kersebaum, K. C.; Launay, M.; Lewan, E.; Liu, K.; Luo, Q.; Mequanint, F.; Nendel, C.; Padovan, G.; Olesen, J. E.; Pullens, J. W. M.; Qian, B.; Seserman, D.-M.; Shelia, V.; Souissi, A.; Specka, X.; Wang, J.; Weber, T. K. D.; Weihermuller, L.; Seidel, S.
10.1101/2023.02.03.526931 — plant biology — Posted on 2025-05-14
3184 Large Language Models Can Extract Metadata for Annotation of Human Neuroimaging Publications
Turner, M. D.; Appaji, A.; Ar Rakib, N.; Golnari, P.; Rajasekar, A. K.; Rathnam K V, A.; Sahoo, S. S.; Wang, Y.; Wang, L.; Turner, J. A.
10.1101/2025.05.13.653828 — bioinformatics — Posted on 2025-05-14
3187 DNA-methylation markers associated with lung function at birth and childhood reveal early life programming of inflammatory pathways
Kachroo, P.; Shutta, K. H.; Maiorino, E.; Moll, M.; Hecker, J.; Carey, V. J.; McGeachie, M. J.; Litonjua, A. A.; Celedon, J. C.; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, ; Weiss, S. T.; DeMeo, D. L.
10.1101/2025.05.12.653131 — genomics — Posted on 2025-05-14
3189 Randomized field trial of a therapeutic vaccine against Trypanosoma cruzi natural infection in dogs and correlates for efficacy
Calderon-Quintal, J. A.; Teh-Poot, C.; Piste, L. M. P.; Martinez-Vega, P. P.; Dzul-Huchim, V.; Torres-Acosta, F.; Waleckx, E.; Villanueva-Lizama, L. E.; Ortega-Lopez, J.; Herrera, C.; Dumonteil, E.; Cruz-Chan, J. V.
10.1101/2025.05.12.653529 — microbiology — Posted on 2025-05-14
3191 Opposing Modulation of EEG Aperiodic Component by Ketamine and Thiopental: Implications for the Noninvasive Assessment of Cortical E/I Balance in Humans
Cortes-Briones, J.; Urrutia-Gandolfo, J.; Estevez, P.; Sengupta, A.; Basilico, M.; Skosnik, P.; Limoncelli, D.; D'Souza, D. C.; Petrakis, I.; Krystal, J.
10.1101/2025.05.12.653580 — neuroscience — Posted on 2025-05-14
3196 A novel non-catalytic function of PA2803-encoded PcrP contributes to polymyxin B resistance in P. aeruginosa and redefines the functional role of the PA2803 subfamily.
Salpadoru, T.; Khanam, S. S.; Borin, V.; Achour, M.; Oh, D.; Kanik, M.; Gallage, P.; Khanov, A.; Hull, M.; Pitre, S.; Agarwal, P. K.; Franklin, M. J.; Patrauchan, M. A.
10.1101/2025.05.13.653872 — microbiology — Posted on 2025-05-13
3197 Spontaneous spiking statistics form unique area-specific fingerprints and reflect the hierarchy of cerebral cortex
Morales-Gregorio, A.; Gutzen, R.; Paneri, S.; Sapountzis, P.; Kleinjohann, A.; Grün, S.; Riehle, A.; Chen, X.; Brochier, T.; Gregoriou, G. G.; Kilavik, B. E.; van Albada, S. J.
10.1101/2025.05.13.653871 — neuroscience — Posted on 2025-05-13
3198 Diverse activity in prefrontal projections promotes temporal control of action
Ding, X.; Weber, M. A.; Butler, T.; Bova, A. S.; Guerrero, S.; Hunter, C.; Cole, R. C.; Stutt, H. R.; McMurrin, M. A.; Spicer, M.; Conlon, M. M.; Heiney, S. I.; Resch, J. M.; Narayanan, N. S.
10.1101/2025.05.12.653607 — neuroscience — Posted on 2025-05-13
3199 Alpha power indexes working memory load for durations
Herbst, S. K.; Mangione, I.; Segerie, C. R.; Hoechenberger, R.; Kononowicz, T. W.; Gramfort, A.; van Wassenhove, V.
10.1101/2025.05.12.653390 — neuroscience — Posted on 2025-05-13
3201 Assessing genomic reproducibility of read alignment tools
Baykal, P. I.; Simonov, M.; Deshpande, D.; Korukoglu, F. B.; Moore, J.; Chhugani, K.; Liu, C.; Sarwal, V.; Rajkumar, N.; Alser, M.; Beerenwinkel, N.; Mangul, S.
10.1101/2025.05.08.652934 — bioinformatics — Posted on 2025-05-13
3202 RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood
Navarro-Delgado, E. I.; Czamara, D.; Edwards, K.; Fu, M. P.; Merrill, S. M.; Konwar, C.; MacIsaac, J. L.; Lin, D. T.; Mandhane, P. J.; Simons, E.; Subbarao, P.; Moraes, T. J.; Lahti, J.; Miller, G. E.; Binder, E. B.; Räikkönen, K.; Turvey, S.; Korthauer, K.; Kobor, M. S.
10.1101/2025.05.08.652964 — bioinformatics — Posted on 2025-05-13
3206 The distribution of fitness effects varies phylogenetically across animals
Lin, M.; Chakraborty, S.; Amorim, C. E. G.; Morales, S. N.; Beichman, A. C.; Nunez-Valencia, P. G.; Mah, J. C.; Ronbinson, J. A.; Kyriazis, C. C.; Huber, C. D.; Webb, A. E.; Kocher, S. D.; Archer, F. I.; Moreno-Estrada, A.; Wayne, R. K.; Lohmueller, K. E.
10.1101/2025.05.13.653358 — evolutionary biology — Posted on 2025-05-13
3212 Inhibitory TIGIT signalling is dependent on T cell receptor activation
Zammit, W. H.; Le Maistre, L.; Elliot, T. A. E.; Cain, S. A.; Humphries, M. J.; Davis, D. M.; Worboys, J. D.
10.1101/2025.05.08.652881 — immunology — Posted on 2025-05-13
3213 Neuropeptidergic transmission shapes emergent properties of prefrontal cortical circuits underlying learning
Arenivar, M. A.; Ross, N.; Flores, R. J.; Zakariya, S.; Wang, Z. Z.; Yarur, H. E.; Kore, R.; Richiez-Mateo, W. V.; Limoges, A.; Wang, H.; Bravo-Rivera, H.; Agbor-Enoh, D.; Enriquez-Traba, J.; Gu, X.; Averbeck, B.; Li, Y.; Tejeda, H.
10.1101/2025.05.13.653840 — neuroscience — Posted on 2025-05-13
3216 POPARI: Modeling multisample variation in spatial transcriptomics
Alam, S.; Zhou, T.; Haber, E.; Chidester, B.; Liu, S.; Chen, F.; Ma, J.
10.1101/2025.05.08.652741 — bioinformatics — Posted on 2025-05-13
3217 Toward Reliable Synthetic Omics: Statistical Distances for Generative Models Evaluation
Marchesi, R.; Lazzaro, N.; Leonardi, G.; Rignanese, F.; Bovo, S.; Chierici, M.; Jurman, G.
10.1101/2025.05.08.652855 — bioinformatics — Posted on 2025-05-13
3223 Targeted loss of heterozygosity in Candida albicans using CRISPR-Cas9
Despres, P. C.; Gervais, N. C.; Fogal, M.; Rogers, R. K.; Cuomo, C. A.; Shapiro, R. S.
10.1101/2025.05.13.653461 — microbiology — Posted on 2025-05-13
3226 An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies
Henshall, I. G.; Chmielewski, J.; Angange, D.; Romeo, O.; Lai, K. H.; Turland, K. R.; Badii, N.; Foley, M.; Anders, R. F.; Beeson, J.; Wilson, D. W.
10.1101/2025.05.13.653866 — microbiology — Posted on 2025-05-13
3227 Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.
Howard, M.; Farrar, C. A.; Nauser, C.; Jeon, Y.; Polycarpou, A.; Smolarek, D.; Greenlaw, R.; Garred, P.; Alexandra, D.; Mukhopadhyay, S.; Sacks, S.
10.1101/2025.05.08.652605 — immunology — Posted on 2025-05-13
3228 Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
Rahimi, R. A.; Smith, N. P.; Selle, A.; Best, R.; Martin, S.; Tuttle, E.; Ling, M. F.; Medoff, B.; Villani, A.-C.; Luster, A. D.
10.1101/2025.05.08.652962 — immunology — Posted on 2025-05-13
3229 Acetaminophen attenuates pathological pain through a mechanism that requires CB1 cannabinoid receptors and the enzyme diacylglycerol lipase in mice
Jesus, C. A.; Wirt, J. L.; Ferreira, L. A.; Hainline, J.; Huizenga, M.; Rems, L.; Makriyannis, A.; van der Stelt, M.; Hohmann, A. G.
10.1101/2025.05.08.652937 — neuroscience — Posted on 2025-05-13
3230 Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy
Arecchi, G.; Dente, M.; Ma, W.; Scellini, B.; Piroddi, N.; Scardigli, M.; Yu, J.; Zhao, J.; Cicchi, R.; Kinegawa, R.; Muellenbroich, C.; Poggesi, C.; Ferrantini, C.; Irving, T.; Regnier, M.; Sacconi, L.; Tesi, C.
10.1101/2025.05.08.652664 — physiology — Posted on 2025-05-13
3231 The mouse pangenome reveals the structural complexity of the murine protein coding landscape
Helmy, M.; Li, J. U.; Yan, X. F.; Meade, R. K.; Anderson, E.; Chen, P.; Czechanski, A. M.; Di Domenico, T.; Flint, J.; Garrison, E.; Guarracino, A.; Gontijo, M. T.; Haggerty, L.; Heard, E.; Howe, K.; Meena, N.; Martin, F. J.; Miska, E.; Rall, I.; Ramakrishna, N. B.; Sapetschnig, A.; Sinha, S.; Sun, D.; Tricomi, F. F.; Qu, R.; Wood, J. M.; Wu, T.; Zhou, D. J.; Reinholdt, L.; Adams, D. J.; Smith, C. M.; Lilue, J.; Keane, T. M.
10.1101/2025.05.13.653481 — genomics — Posted on 2025-05-13
3233 Molecular insights into nucleocapsid assembly and transport in Marburg and Ebola viruses
Takamatsu, Y.; Dolnik, O.; Hirabayashi, A.; Okamoto, K.; Kurashige, T.; Hu, S.; Oda, C. H.; Noda, T.
10.1101/2025.05.13.653679 — microbiology — Posted on 2025-05-13
3234 Investigating Bacterial Contributions to Thermal Tolerance in Three Intertidal Marine Snail Tegula species
Applegate, B.; Burkhart, M.; Caddow, H.; Gover, B.; Kantola, M.-F.; Obenchain, J. G.; Smith, A.; Nash, B.; Enke, R. A.; Gleason, L. U.
10.1101/2025.05.13.653156 — microbiology — Posted on 2025-05-13
3236 LicD-Mediated Cell Wall Decoration Governs Phage Sensitivity in Enterococcus faecalis Clinical Isolates
Awad, M.; Bouras, G.; Feizi, S.; Grigson, S. R.; Wormald, P.-J.; Psaltis, A. J.; Vreugde, S.
10.1101/2025.05.13.653012 — microbiology — Posted on 2025-05-13
3237 Leaf Mold Agar Facilitates Recovery of Soil Bacterial Diversity Beyond Bacillus Dominance
Tabuchi, F.; Mikami, K.; Ishii, M.; Yasukawa, J.; Miyauchi, M.; Silva, D. P. N. d.; Miyashita, A.
10.1101/2025.05.13.653698 — microbiology — Posted on 2025-05-13
3238 Co-infection with Streptococcus and Rothia spp. drives prophage dynamics in Pseudomonas aeruginosa in an artificial sputum model
Wright, L. L.; Cazares, A.; Figueroa, W.; Chatterley, L. C.; Willmott, T. O.; O'Brien, S.; Fothergill, J.
10.1101/2025.05.13.653867 — microbiology — Posted on 2025-05-13
3240 Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth
Li, D.; Zheng, H.; Bai, Y.; Zhang, Z.; Cheng, H.; Huang, X.; Wei, T.; Zaritsky, A.; Hwa, T.; Liu, C.
10.1101/2025.05.13.653648 — microbiology — Posted on 2025-05-13
3241 Design and development of lysyl tRNA synthetase inhibitors, for the treatment of tuberculosis
Davis, S. H.; Mathieson, M.; Buchanan, K. I.; Dawson, A.; Smith, A.; Cocco, M.; Tamaki, F. K.; Post, J.; Baragana, B.; Jansen, C.; Kiczun, M.; Zuccotto, F.; Wood, G.; Scullion, P.; Ray, P. C.; Epemolu, O.; Lopez-Roman, E. M.; Guijarro Lopez, L.; Engelhart, C. A.; Kim, J.; Pino, P. A.; Schnappinger, D.; Read, K. D.; Encinas, L.; Bates, R. H.; Wyatt, P. G.; Green, S. R.; Cleghorn, L. A.
10.1101/2025.05.13.646596 — microbiology — Posted on 2025-05-13
3244 Viral silencing suppressor activity in plants modifies aphid antiviral immunity and fecundity
Preising, S. E.; Wilson, J. R.; Parker, G. M.; DeBlasio, S. L.; Reeve, D.; Chappie, J. S.; Heck, M. L.
10.1101/2025.05.13.653761 — microbiology — Posted on 2025-05-13
3245 Single-Stranded nucleic acid binding enhances the in vitro catalytic activity of Chikungunya virus nsP2 protease
Mastalipour, M.; Coronado, M. A.; Siahaan, R. A.; Drees, A.; Ahlers, C.; Fischer, M.; Willbold, D.; Eberle, R. J.
10.1101/2025.05.13.653680 — biochemistry — Posted on 2025-05-13
3246 Long range mutual activation establishes Rho and Rac polarity during cell migration
De Belly, H.; Gallen, A. F.; Strickland, E.; Estrada, D. C.; Zager, P. J.; Nagy, T. L.; Burkhardt, J. K.; Turlier, H.; Weiner, O.
10.1101/2024.10.01.616161 — cell biology — Posted on 2025-05-13
3247 Structural basis of RNA polymerase II transcription on the H3-H4 octasome
Ho, C.-H.; Nozawa, K.; Nishimura, M.; Oi, M.; Kujirai, T.; Ogasawara, M.; Ehara, H.; Sekine, S.-i.; Takizawa, Y.; Kurumizaka, H.
10.1101/2025.05.13.653634 — molecular biology — Posted on 2025-05-13
3248 A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants
Ma, Y.; Ye, C.; Khalil, A. M.; Mahmoud, S. H.; Sobolik, E. B.; Greninger, A. L.; Castro, E.; Jackson, N.; Bayoumi, M.; Plemper, R. K.; Martinez-Sobrido, L.
10.1101/2025.05.09.653029 — microbiology — Posted on 2025-05-13
3250 Mycobacterium tuberculosis MutT4 is an RNA pyrophosphohydrolase that forms biomolecular condensates and sensitizes mRNAs to degradation
Cafiero, J. H.; Xiao, J.; Lepori, I.; Rapiejko, A. R.; Reddy, M.; Roberts, L.; Siegrist, M. S.; Sacchettini, J. C.; Shell, S. S.
10.1101/2025.05.13.653832 — microbiology — Posted on 2025-05-13
3251 Conditional filamentation enhances bacterial survival in toxic environments
Aguilar Luviano, O. B.; Santos-Escobar, F.; Orozco-Barrera, S.; Pena-Miller, R.
10.1101/2025.05.13.653778 — microbiology — Posted on 2025-05-13
3253 Non-redundant cardiolipin synthases support membrane integrity and stress resilience in Bacteroides fragilis
Schnizlein, M. K.; Hong, B. J.; Nguyen, J. N. T.; Jones, K.; Rodriguez, A. I.; Fiebig, A.; Campagna, S. R.; Balunas, M. J.; O'Halloran, T. V.; Crosson, S.
10.1101/2025.05.12.653583 — microbiology — Posted on 2025-05-13
3256 Organic carbon oxidation state shapes fermentative methanogenic microbiomes and controls greenhouse gas fluxes
Hu, R.; Aronson, H. S.; Weaver, M. E.; Price, M. N.; Larowe, D. E.; Liang, Y.; Deutschbauer, A. M.; Coates, J. D.; Carlson, H. K.
10.1101/2025.05.12.653603 — microbiology — Posted on 2025-05-13
3257 Composition, growth, succession, and function in the Cladophora microbiome: insights from quantitative Stable Isotope Probing and NanoSIMS imaging
Fitzpatrick, R. M.; Hungate, B. A.; Power, M. E.; Schwartz, E.; Hayer, M.; Samo, T.; Weber, P.; Pett-Ridge, J.; Foley, M.; Marks, J. C.
10.1101/2025.05.12.652736 — microbiology — Posted on 2025-05-13
3259 The Mycobacterium tuberculosis ESX effector promotes pyroptosis-dependent pathogenicity and dissemination
Shen, Y.; He, Y.; Chen, A.; Li, Y.; Gao, Y.; Liu, X.; Geng, L.; Ye, M.; Qiu, Y.; Zhang, L.; Sun, Y.-C.; Yang, H.; Li, J.
10.1101/2025.05.13.653593 — microbiology — Posted on 2025-05-13
3260 Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines
Addetia, A.; Schaefer, A.; Sprouse, K.; Valdez, A.; Taylor, A.; Navarro, M.-J.; Brown, J. T.; Leaf, E.; Miranda, M.; Walls, A. C.; Lee, J.; Catanzaro, N. J.; Treichel, C.; Willoughby, I.; Powers, J.; Martinez, D. R.; Vesari, B.; Ravichandran, R.; Seo, A. J.; Stewart, C.; Merz, B.; Beirne, E.; Zepeda, S.; Cook, A.; Pessaint, L.; Sharma, A.; Edwards, D.; Lee, K.; Smith, K.; Starr, T. N.; Baric, R.; King, N. P.; Veesler, D.
10.1101/2025.05.11.652904 — immunology — Posted on 2025-05-13
3267 Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period
Pillutla, S. V.; Skoda, M. J.; Ishii, A.; Corenblum, M. J.; Montgomery, T.; Wene, P. V.; Menakuru, N.; Kraszewski, J. N.; Billheimer, D.; Winter, G. M.; Cowen, S. L.; Madhavan, L.
10.1101/2025.05.06.652460 — neuroscience — Posted on 2025-05-13
3270 Phage-displayed synthetic library and screening platform for nanobody discovery
Xia, B.; Kim, A.-R.; Liu, F.; Han, M.; Stoneburner, E.; Makdissi, S.; Di Cara, F.; Mohr, S.; Ring, A.; Perrimon, N.
10.1101/2024.12.20.629765 — biochemistry — Posted on 2025-05-13
3271 Bacteroidales T6SS minor Hcp subunits form heteromers recognising effectors
San-Miguel, S. G.; Al-Ammari, M. K. S.; Kowalska, A.; Sauer, U.; Batista, P. R.; Sandblad, L.; Uhlin, B. E.; Cisneros, D. A.
10.1101/2025.01.09.632221 — biochemistry — Posted on 2025-05-13
3275 Novel Fluorescent and Photoconvertible Fusions Reveal Dorsal Activator Dynamics
Turner, M. A.; Gravina, N. M.; Moretti, B.; Dima, S. S.; Martini, G.; Reeves, G. T.; Garcia, H.
10.1101/2025.05.12.653543 — developmental biology — Posted on 2025-05-13
3279 Gene therapy prevents disease and death from non-ketotic hyperglycinemia
Lopez-Ramirez, A.; Bali, A.; Alam, M. S.; Padmanabhan, P.; Calhoun, S.; Bickerton, C.; Flores-Mireles, A. L.; Haldar, K.
10.1101/2025.03.26.645560 — neuroscience — Posted on 2025-05-13
3280 Working memory by distributed neural oscillators in a simple nervous system
Dunn, R. L.; Costello, C.; Borchardt, J. M.; Sprague, D. Y.; Chiu, G. C.; Miller, J. M.; L'Etoile, N.; Kato, S.
10.1101/2024.08.11.607402 — neuroscience — Posted on 2025-05-13
3282 Mixed DAMP/MAMP oligosaccharides promote both growth and defense against fungal pathogens of cucumber
Pring, S.; Kato, H.; Taniuchi, K.; Camagna, M.; Saito, M.; Tanaka, A.; Merritt, B. A.; Arguello-Miranda, O.; Sato, I.; Chiba, S.; Takemoto, D.
10.1101/2024.12.27.630494 — plant biology — Posted on 2025-05-13
3283 Influence of High-Fat Diet and Sex on Connective Tissue in Carpal Tunnel Syndrome
Kuroiwa, T.; Lui, H.; Nakagawa, K.; Iida, N.; Desrochers, C.; Wan, R.; Nishimura, K.; Adam, E.; Larson, D.; Amadio, P. C.; Gingery, A.
10.1101/2023.07.15.549152 — physiology — Posted on 2025-05-13
3284 DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient Survival
Iluz, A.; Lavi, N.; Charbit, H.; Gutreiman, M.; Idelson, M.; Steiner, D.; Ben-Shushan, E.; Zick, A.; Eden, A.; Mordechai, A.; Moscovici, S.; Fellig, Y.; Lossos, A.; Moss, J.; Reubinoff, B. E.; Lavon, I.
10.1101/2025.02.27.640603 — cancer biology — Posted on 2025-05-13
3287 STI1 domain dynamically engages transient helices in disordered regions to drive self-association and phase separation of yeast ubiquilin Dsk2
Acharya, N.; Daniel, E. A.; Dao, T. P.; Niblo, J. K.; Mulvey, E.; Sukenik, S.; Kraut, D. A.; Roelofs, J.; Castaneda, C. A.
10.1101/2025.03.14.643327 — biochemistry — Posted on 2025-05-13
3288 DAF-16/Foxo suppresses the transgenerational sterility of prg-1 piRNA mutants via a systemic small RNA pathway
Simon, M.; Spichal, M.; Heestand, B.; Frenk, S.; Hedges, A.; Godwin, M.; Wellman, A.; Sakaguchi, A.; Ahmed, S.
10.1101/326751 — genetics — Posted on 2025-05-13
3292 Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation
Jia, C.; Tran, A.; Aloboudi, F.; Say, E.; Thao, N.; Lee, C. R.; Batra, K.; Nguyen, A.; Bal, A.; Nono, N. N.; Delahanty, J.; Chan, M. G.; Keyes, L. R.; Patel, R. R.; Wichmann, R.; Taschbach, F.; Li, Y.; Benna, M. K.; Pereira, T. D.; Li, H.; Tye, K. M.
10.1101/2025.05.09.653162 — neuroscience — Posted on 2025-05-13
3293 A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding
Rusu, I.; Cecere, Z. T.; How, J. J.; Quach, K. T.; Yemini, E.; Sharpee, T. O.; Chalasani, S. H.
10.1101/2021.04.09.439242 — neuroscience — Posted on 2025-05-13
3296 H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cells
Cooke, E. W.; Zeng, C.; Nur, S. M.; Jia, Y.; Huang, A.; Chen, J.; Gao, P.; CHEN, F. X.; Jin, F.; Cao, K.
10.1101/2025.05.08.652740 — genetics — Posted on 2025-05-13
3299 Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes
Chawla, A. S.; Watt, H. J.; Schattgen, S. A.; Skariah, N.; Saha, I.; Warrick, K.; Ogawa, M.; Lamoliatte, F.; Strid, J.; Copland, A.; Pryde, S.; Knatko, E.; Rasmussen, K. D.; Kikuchi, K.; Thomas, P. G.; Pasare, C.; Bending, D.; Swamy, M.
10.1101/2023.09.01.555859 — immunology — Posted on 2025-05-13
3300 Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Fan, X.-R.; He, Y.; Wang, Y.-S.; Li, L.; Lifespan Brain Chart Consortium (LBCC), ; China Autism Brain Imaging Consortium (CABIC), ; Duan, X.; Zuo, X.-N.
10.1101/2025.02.24.639771 — neuroscience — Posted on 2025-05-13
3301 AmygdalaGo-BOLT: an open and reliable AI tool to trace boundaries of human amygdala
Zhou, Q.; Dong, B.; Gao, P.; Jintao, W.; Xiao, J.; Wang, W.; Liang, P.; Lin, D.; Zuo, X.-N.; He, H.
10.1101/2024.08.11.607487 — neuroscience — Posted on 2025-05-13
3302 Impacts of wind-driven hydrodynamics on the early stages of coral development
Buccheri, E.; Wuppukondur, A.; Ricardo, G. F.; Mumby, P. J.; Doropoulos, C.
10.1101/2025.05.07.652727 — systems biology — Posted on 2025-05-13
3303 Direct quantitative assessment using digital droplet PCR and field-scale spatial distribution of Plasmopara viticola oospores in vineyard soil
Poeydebat, C.; Courchinoux, E.; Demeaux, I.; Rodriguez, M.; Chataigner, A.; Lelievre, M.; Goutouly, J.-P.; Rossi, J.-P.; Raynal, M.; Deliere, L.; Francois, D.
10.1101/2024.07.29.605284 — plant biology — Posted on 2025-05-13
3310 Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery
Murad, J. P.; Christian, L.; Rosa, R.; Ren, Y.; Lee, E.; Lopez, L.; Park, A.; Yang, J.; Trac, C.; Adkins, L.; Chang, W.-C.; Martinez, C.; June, C. H.; Forman, S.; Ishihara, J.; Lee, J. K.; Stern, L.; Priceman, S. J.
10.1101/2025.04.04.647304 — bioengineering — Posted on 2025-05-13
3313 Transcription factor occupancy is affected by genetic variation in the white adipose tissue of C57BL6/j and 129S1/SvImJ mice
Mononen, J.; Taipale, M.; Malinen, M.; Levonen, A.-L.; Ruotsalainen, A.-K.; Norton, L.; Heikkinen, S.
10.1101/2025.05.08.652810 — genetics — Posted on 2025-05-13
3314 Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms
Lardennois, A.; Dingare, C.; Duda, V.; Klemmt, P. A.; Heinzen, C.; Kleinhans, D.; Falk, T.; Schelmbauer, C.; Mozolewska, O.; Papadopoulou, S.; Lai, J. J. K.; Stainier, D. Y. R.; Lecaudey, V.
10.1101/2025.05.08.652796 — developmental biology — Posted on 2025-05-13
3315 A Novel Framework for Quantitative Analysis of Neuronal Primary Cilia in Brain Tissue
H.Rafati, A.; Rasmusson, S.; Jabbari Shiadeh, S. M.; J Rosario, F.; Jansson, T.; Mallard, C.; Ardalan, M.
10.1101/2025.05.09.653053 — neuroscience — Posted on 2025-05-13
3318 Pseudoassembly of k-mers
Sullivan, D. K.; Boffelli, M.; Pachter, L.
10.1101/2025.05.11.653354 — bioinformatics — Posted on 2025-05-13
3319 rDNAcaller: a fast and robust pipeline to call ribosomal DNA variants
Ramirez, J. M.; Oliveros, W.; Garcia-Perez, R.; Jimenez-Lupianez, A.; Shah, A.; Perez-Cano, P.; Reese, F.; Vazquez, M.; Mele, M.
10.1101/2025.05.13.653643 — bioinformatics — Posted on 2025-05-13
3320 Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy
Flannery, K. P.; Mowla, S.; Battula, N.; Clark, L. R.; Liu, D.; Oliveira, C. D.; Venkatesan, C.; Simhon, L. M.; Karas, B. F.; Terez, K. R.; Burbano Lombana, D.; Manzini, M. C.
10.1101/2025.05.13.653769 — genetics — Posted on 2025-05-13
3323 A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription
Minello, A.; Gomez-Escudero, J.; Sridhara, S. C.; Martin, C.; Girard, E.; Canas, J. C.; Memari, Y.; Bustos, M. R.; Galarreta, A.; Boucherit, V.; Imyanitov, E.; Bodvarsdottir, S. K.; Baulande, S.; Vincent-Salomon, A.; Servant, N.; Altmeyer, M.; Sigurdsson, S.; Stoppa-Lyonnet, D.; Nik-Zainal, S.; Carreira, A.
10.1101/2025.05.12.652853 — cancer biology — Posted on 2025-05-13
3324 p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
Kumar, R.; Couly, S.; Muys, B. R.; Li, X. L.; Grammatikakis, I.; Singh, R.; Guest, M.; Wen, X.; Tang, W.; Ambs, S.; Jenkins, L. M.; Pehrsson, E. C.; Chari, R.; Su, T.-P.; Lal, A.
10.1101/2025.05.12.653341 — cancer biology — Posted on 2025-05-13
3326 Development of a liquid biopsy for bladder cancer using a mutant protein panel in urinary extracellular vesicles
Hakozaki, Y.; Sugimoto, K.; Yamada, Y.; Danno, T.; Hashimoto, K.; Shinchi, H.; Kume, H.; Ueda, K.
10.1101/2025.05.12.653366 — cancer biology — Posted on 2025-05-13
3327 CD4+ T-cells sensitize quasi-mesenchymal breast tumors lacking CD73 to anti-CTLA4 immune checkpoint blockade therapy
Chandraganti, S. R.; Sams, C.; Sahoo, S.; Feng, B.; O'Connell, I.; Li, L.; Nepal, S.; Pulukuri, S.; Bakhle, K.; Thiru, P.; Simian, C.; Bell, G. W.; Jolly, M. K.; Dongre, A.
10.1101/2025.05.12.653467 — cancer biology — Posted on 2025-05-13
3328 Cancer cell deformability impacts the rate of confined migration but not decision making
van der Net, A.; Boot, R. C.; van Dijk, I.; Conboy, J. P.; Boukany, P. E.; Koenderink, G. H.
10.1101/2025.05.12.653524 — cancer biology — Posted on 2025-05-13
3329 Local, but not circulating, complement C3 governs immune checkpoint blockade efficacy
Miyai, Y.; Shiraki, Y.; Sugiyama, D.; Sato, Y.; Kato, K.; Asai, N.; Cao, F.; Nagao, N.; Tanabe, K.; Nakatochi, M.; Hase, T.; Yoshikawa, T. F. C.; Kobayashi, T.; Iwama, S.; Esaki, N.; Mii, S.; Arima, H.; Kimura, H.; Takahashi, M.; Ando, Y.; Enomoto, A.
10.1101/2025.05.12.653608 — cancer biology — Posted on 2025-05-13
3330 Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product
Jagannathan, N. S.; Sin, W.-X.; Teo, D. B. L.; Kairi, F.; Luah, Y. H.; Lim, F. L. W. I.; Seng, M. S.-F.; Soh, S. Y.; Lee, Y. H.; Tucker-Kellogg, L.; Birnbaum, M. E.; Ram, R. J.
10.1101/2025.05.11.653250 — cancer biology — Posted on 2025-05-13
3335 Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli
Mukherjee, A.; Huang, Y.; Oh, S.; Sanchez, C.; Chang, Y.-F.; Liu, X.; Bradshaw, G. A.; Benites, N. C.; Paulsson, J.; Kirschner, M. W.; Sung, Y.; Elgeti, J.; Basan, M.
10.1101/2023.08.31.555748 — microbiology — Posted on 2025-05-13
3336 Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants
Jian, F.; Wec, A. Z.; Feng, L.; Yu, Y.; Wang, L.; Wang, P.; Yu, L.; Wang, J.; Hou, J.; Berrueta, D. M.; Lee, D.; Speidel, T.; Ma, L.; Kim, T.; Yisimayi, A.; Song, W.; Wang, J.; Liu, L.; Yang, S.; Niu, X.; Xiao, T.; An, R.; Wang, Y.; Shao, F.; Wang, Y.; Pecetta, S.; Wang, X.; Walker, L. M.; Cao, Y.
10.1101/2024.04.16.589454 — immunology — Posted on 2025-05-13
3339 Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics
Saraswat, M.; Rueda-Gensini, L.; Heinzelmann, E.; Gracia, T.; Memi, F.; de Jong, G.; Straub, J.; Schloo, C.; Hoffmann, D. C.; Jung, E.; Kindinger, T.; Weigel, B.; Lim, B.; Weil, S.; Gould, O.; Mair, R.; Mikulik, K.; Rohbeck, M.; Wick, W.; Winkler, F.; Bayraktar, O. A.; Stegle, O.; Mall, M.
10.1101/2025.05.13.653733 — cancer biology — Posted on 2025-05-13
3340 Oxidative Base Damage to Telomeres Sensitizes Cancer Cells to ATR Inhibition
Garbouchian, A.; Cestari Moreno, N.; Dey, A.; Opresko, P.; Barnes, R. P.
10.1101/2025.05.10.653274 — cancer biology — Posted on 2025-05-13
3341 Mechanoimmunological Control of Metastatic Site Selection
Elbanna, Y. A.; Tello-Lafoz, M.; Holland, A.; Zhang, Y.; Kwak, J.-G.; Wang, Z.; Yakimov, A.; Dada, M.; Vayner, S.; Duquette, S. M.; Kim, Y. H.; Bale, T.; Winer, B. Y.; Yu, K. K. H.; Massague, J.; Lee, J.; Barzilai, O.; Manalis, S. R.; Huse, M.
10.1101/2025.05.10.653256 — cancer biology — Posted on 2025-05-13
3342 Resistance to the KRASG12D Inhibitor MRTX1133 is Associated with Increased Sensitivity to BET Inhibition
Principe, D. R.; Becker, J. H.; Metropulos, A. E.; Marinelarena, A. M.; Pham, T. D.; Aissa, A. F.; Munshi, H. G.
10.1101/2025.05.10.653074 — cancer biology — Posted on 2025-05-13
3346 Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry
Welp, L. M.; Wulf, A.; Chernev, A.; Horokhovskyi, Y.; Moshkovskii, S.; Dybkov, O.; Neumann, P.; Pasen, M.; Siraj, A.; Raabe, M.; Goethert, H.; Walshe, J. L.; Infante, D. A.; de A.P. Schwarzer, A. C.; Dickmanns, A.; Johannsson, S.; Schmitzova, J.; Wohlgemuth, I.; Netz, E.; He, Y.; Fritzemeier, K.; Delanghe, B.; Viner, R.; Vos, S.; Oberbeckmann, E.; Bohnsack, K. E.; Bohnsack, M. T.; Cramer, P.; Ficner, R.; Liepe, J.; Kohlbacher, O.; Sachsenberg, T.; Urlaub, H.
10.1101/2024.08.29.610268 — biochemistry — Posted on 2025-05-13
3348 When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion
Dengler, L.; Padovani, F.; Lemke, B.; Brugger, R.; Westermann, B.; Macek, B.; Schmoller, K. M.; Ewald, J. C.
10.1101/2025.05.13.653688 — cell biology — Posted on 2025-05-13
3349 KIF5B and Dynein regulate adhesion-dependent Golgi organization and microtubule acetylation
Chakraborty, A.; Pitke, S.; BR, R.; Buwa, N.; Dasgupta, A.; Behera, R.; Jayakrishnan, M.; Balasubramanian, N.
10.1101/2025.05.11.653231 — cell biology — Posted on 2025-05-13
3351 Mechanical forces drive mitochondrial matrix extrusion and apoptotic pore growth
Jenner, A.; Dellmann, T.; Kim, H.; Gomez, D.; Zollo, C.; Koefinger, J.; Seidel, K.; Gaedke, F.; Schauss, A.; Hummer, G.; Garcia-Saez, A. J.
10.1101/2025.05.12.653510 — cell biology — Posted on 2025-05-13
3354 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
Tsai, Y.-T.; Frederic-Lipp, N.; Varma, R.; Seidel, O.; Laguerre, A.; Solorio-Kirpichyan, K.; Wong, A.; Brea, R. J.; McGregor, G. H.; Cordes, T.; Devaraj, N. K.; Kuerschner, L.; Neal, S. E.; Metallo, C.; Budin, I.
10.1101/2025.05.13.652513 — cell biology — Posted on 2025-05-13
3355 A key role for Canoes intrinsically disordered region in linking cell junctions to the cytoskeleton
Jensen, C.; Gurley, N.; Mathias, A.; Wolfsbrrg, L.; Xiao, Y.; Zhou, Z.; Slep, K. C.; Peifer, M.
10.1101/2025.05.10.653259 — cell biology — Posted on 2025-05-13
3356 CellSeg3D: self-supervised 3D cell segmentation for fluorescence microscopy
Achard, C.; Kousi, T.; Frey, M.; Vidal, M.; Paychere, Y.; Hofmann, C.; Iqbal, A.; Hausmann, S. B.; Pages, S.; Mathis, M. W.
10.1101/2024.05.17.594691 — cell biology — Posted on 2025-05-13
3359 Thermal cycling stimulation via nasal inhalation attenuates Aβ25-35-induced cognitive deficits in C57BL/6 mice
Lin, G.-B.; LIU, H.-H.; Kuo, Y.-Y.; CHEN, Y.-M.; Hsu, F.-T.; Wang, Y.-W.; Kung, Y.; Ching, C.; Chao, C.-Y.
10.1101/2025.05.08.652792 — neuroscience — Posted on 2025-05-13
3360 A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson's disease
Zhang, J.-X.; Smyth, C.; Anjum, M. F.; Leng, Y.; Krystal, A. D.; Starr, P. A.; Little, S.
10.1101/2025.05.07.652676 — neuroscience — Posted on 2025-05-13
3362 Neuropeptide signalling and perineurial barrier generate a persistent stress-induced internal state in Drosophila
Alia, A. G.; Hu, X.; Gu, Y.; Tian, G.; Semmelhack, J.; Saito, K.; Tanimoto, H.; Tsuyuzaki, K.; Naganos, S.; Miyashita, T.; Saitoe, M.; Hirano, Y.
10.1101/2025.05.08.652787 — neuroscience — Posted on 2025-05-13
3364 Changes in slow oscillations and sleep spindles by auditory stimulation positively correlate with memory consolidation in children with epilepsy and controls
Kwon, H.; Chinappen, D. M.; Wodeyar, A.; Kinard, E. A.; Goodman, S. K.; Shi, W.; Baxter, B. S.; Manoach, D. S.; Kramer, M. A.; Chu, C. J.
10.1101/2025.05.12.653459 — neuroscience — Posted on 2025-05-13
3368 BrainVAE: Exploring the role of white matter BOLD in preclinical Alzheimer disease classification
Li, Y.; Xu, L.; Zuo, L.; Chang, Y.; Ding, Z.; Anderson, A. W.; Schilling, K.; Gore, J. C.; Gao, Y.
10.1101/2025.05.07.652697 — neuroscience — Posted on 2025-05-13
3371 Long-lasting coexistence of multiple asexual lineages alongside their sexual counterparts in a fungal plant pathogen
Abdalrahem, A.; Andrieux, A.; Becheler, R.; Duplessis, S.; Frey, P.; Marcais, B.; Schiffer-Forsyth, K.; Stoeckel, S.; Halkett, F.
10.1101/2025.03.28.645883 — evolutionary biology — Posted on 2025-05-13
3374 Varroa mites escape the evolutionary trap of haplodiploidy
Eliash, N.; Tetsuya, E.; Hua, X.; Johnston, S. J.; TECHER, M. A.; Holmes, V. R.; Rangel, J.; Zheng, H.; Economo, E. P.; Mikheyev, A. S.
10.1101/2024.05.10.593493 — evolutionary biology — Posted on 2025-05-13
3377 Revisiting sour rot of grapevine through disease-associated microbiomes: a tripartite co-infection?
Wilhelm, M.; Hevin, S.; Kehrli, P.; Buyck, B.; Gindro, K.; Wolfender, J.-L.; Hofstetter, V.
10.1101/2024.09.19.613941 — microbiology — Posted on 2025-05-13
3383 Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2
Sengupta, A.; Vinayagamurthy, S.; Soni, D.; Deb, R.; Mukherjee, A. K.; Dutta, S.; Jaiswal, J.; Yadav, M.; Sharma, S.; Bagri, S.; Roy, S. S.; Poonia, P.; Singh, A.; Khanna, D.; Bhatt, A. K.; Sharma, A.; Saurav, S.; Motiani, R. K.; Chowdhury, S.
10.1101/2023.10.09.561466 — cancer biology — Posted on 2025-05-13
3386 NeuroVelo: interpretable learning of cellular dynamics from single-cell transcriptomic data
Kouadri Boudjelthia, I.; Milite, S.; El Kazwini, N.; Huang, Y.; Sottoriva, A.; Sanguinetti, G.
10.1101/2023.11.17.567500 — bioinformatics — Posted on 2025-05-13
3388 Genomic diversity and antimicrobial resistance ofStaphylococcus aureus in Saudi Arabia: a nationwide studyusing whole-genome sequencing
Alarawi, M. S.; Altammami, M.; H. Abutarboush, M.; Kulmanov, M.; Mawsil Alkuraythi, D.; Kafkas, S.; Radley, R.; Abdelhakim, M.; Aldakhil, H. M.; A. Bawazeer, R.; A. Alolayan, M.; M. Alnafjan, B.; A. Huraysi, A.; Almaabadi, A.; A Suliman, B.; G Aljohani, A.; A. Hemeg, H.; Abujamel, T. S.; Hashem, A. M.; Al-Zahrani, I. A.; S Abdoh, M.; I Hobani, H.; F Felemban, R.; A Alhazmi, W.; Hong, P.; Alghoribi, M. F.; Al Johani, S. M.; BALKHY, H. H.; Alswaji, A. A.; ALZAYER, M.; Alalwan, B.; Kaaki, M.; Hala, S.; Ahmad Fallatah, O.; Ahmad Bahitham, W.; Yahya Zakri, S.; A Alshehri, M.; Kameli, N.; Algaissi,
10.1101/2025.03.03.641358 — genomics — Posted on 2025-05-13
3389 Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation
Chen, S.; Liang, J.; Yin, J.; Zhang, W.; Jiang, P.; Wang, W.; Chen, X.; Zhou, Y.; Xia, P.; Yang, F.; Gu, Y.; Zhang, R.; Han, p.
10.1101/2024.05.09.593293 — developmental biology — Posted on 2025-05-13
3390 Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Baako, A. K.; Vijayakumar, R.; Medina-Cano, D.; Wang, Z.; Romero-Pichardo, J.; Fadojutimi, K.; Do, S. C.; Lin, Y.; Islam, M. T.; Dixit, S.; Trzeciak, A.; Perry, J. S. A.; Vierbuchen, T.
10.1101/2025.05.01.651743 — developmental biology — Posted on 2025-05-13
3394 Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans
Zhao, Q.; Bolton, B.; Rothe, R.; Tachibana, R.; Cenik, C.; Sarinay Cenik, E.
10.1101/2025.05.07.652686 — genetics — Posted on 2025-05-13
3395 Rhs-toxin Abundance, Diversity, and Function in Four Genera of Plant Pathogenic Bacteria: Xanthomonas, Ralstonia, Pectobacterium, and Dickeya.
Gomez Cabrera, A.; Ameen, Y. O.; DAmico-Willman, K.; Joglekar, P.; Huguet-Tapia, J.; Carbone, I.; Huerta Vazquez, A. I.
10.1101/2025.05.08.652813 — ecology — Posted on 2025-05-13
3397 Generalized dynamics of cooperating bacteria
Massing, J. C.; Gross, T.; Yeakel, J. D.; Fahimipour, A. K.
10.1101/2025.05.08.652847 — ecology — Posted on 2025-05-13
3400 A 20-years comparative study of domoic acid depuration in king scallops, Pecten maximus, across French provinces.
Le Moan, E.; Derrien, A.; Fabioux, C.; Jean, F.; Lassudrie, M.; Terre-Terrillon, A.; Hegaret, H.; Flye-Sainte-Marie, J.
10.1101/2025.05.08.652798 — ecology — Posted on 2025-05-13
3401 Trans-kingdom coupling of redox signaling to environmental cell stress responses through multiphase partitioning.
Ngwa, E.; Chen, X.; Schmeider, S.; Maurais, A.; Svistunov, V.; Peng, Q.; Moore, I.; Lencer, W. I.; Weerapana, E.; Raghunathan, K.; Thiagarajah, J. R.
10.1101/2025.05.09.653213 — cell biology — Posted on 2025-05-13
3405 Molecular determinants of species-specific cell-cell recognition activating the class II gamete fusogen HAP2
Pinello, J. F.; Ferrino, A.; Hussain, H.; Legrand, P.; Manikumar, S.; Demissie, R.; Rey, F. A.; Snell, W. J.; Baquero, E.
10.1101/2025.05.09.653094 — cell biology — Posted on 2025-05-13
3407 Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism
Medeiros, T. C. D.; Reato, S.; Li, X.; Garcia, B. M.; Rais, I.; Allmeroth, K.; Hartman, M.; Denzel, M.; Purrio, M.; Mesaros, A.; Leung, K.-y.; Greene, N.; Giavalisco, P.; Pernas, L.
10.1101/2025.05.07.652698 — cell biology — Posted on 2025-05-13
3409 In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone Metabolome
Chlebek, C.; McAndrews, C.; Aaronson, B.; Welhaven, H.; Yu, K.; Costa, S. N.; Shaver, J.; Silvia, S.; DeMambro, V.; June, R. K.; McGee-Lawrence, M. E.; Rosen, C. J.
10.1101/2025.05.09.653133 — cell biology — Posted on 2025-05-13
3411 SF3B1K700E Drives Oncogenic Alternative Splicing of Cell Cycle Checkpoint Genes in Cancer
Baker, M.; Sharma, A.; Engal, E.; Petasny, M.; Jaffe-Herman, S.; Geminder, O.; Su, M.; Bentata, M.; Kay, G.; Salton, M.
10.1101/2025.05.08.652831 — molecular biology — Posted on 2025-05-13
3413 Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?
Carolus, H.; Diaz, J.; Biriukov, V.; Jacobs, S.; Sofras, D.; Pageau, A.; Romero, C. L.; Vinken, L.; Escribano, P.; Guinea, J.; Lagrou, K.; Landry, C.; Gabaldon, T.; Van Dijck, P.
10.1101/2025.05.08.652905 — molecular biology — Posted on 2025-05-13
3414 Proteomic and lipidomic profiling of immune cell-derived subpopulations of extracellular vesicles
Lischnig, A.; Karimi, N.; Larsson, P.; Ekstrom, K.; Crescitelli, R.; Olin, A.-C.; Lasser, C.
10.1101/2025.05.08.652936 — molecular biology — Posted on 2025-05-13
3415 Alcohol impacts an fMRI marker of neural inhibition in humans and rodents.
Nishio, M.; Wang, X.; Cornblath, E. J.; Lee, S.-H.; Shih, Y.-Y. I.; Palomero-Gallagher, N.; Arcaro, M.; Lydon-Staley, D. M.; Mackey, A. P.
10.1101/2025.05.07.652668 — neuroscience — Posted on 2025-05-13
3418 α-Synuclein purification significantly impacts seed amplification assay performance and consistency
Al-Azzawi, Z. A. M.; Silver, N. R. G.; Niu, S.; Luo, W.; Shlaifer, I.; Ingelsson, M.; Hyman, B. T.; Trempe, J.-F.; Durcan, T.; Watts, J. C.; Fon, E. A.
10.1101/2025.05.08.652548 — biochemistry — Posted on 2025-05-13
3419 Novel Fluorescent and Photoconvertible Fusions Reveal Dorsal Activator Dynamics
Turner, M. A.; Gravina, N. M.; Moretti, B.; Dima, S. S.; Martini, G.; Reeves, G. T.; Garcia, H.
10.1101/2025.05.12.653543 — developmental biology — Posted on 2025-05-13
3420 Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production
Beckendam, R. H.; Camacho, V.; Stone, A. P.; Barrachina, M. N.; Branfield, S.; Carminita, E.; Becker, I. C.; Lee, D. H.; Walsey, E.; Kaplan, J.; Payne, C.; Tilburg, J.; Pal, S.; Batista, L. F. Z.; Italiano, J. E.; Machlus, K. R.
10.1101/2025.05.08.652525 — cell biology — Posted on 2025-05-13
3421 Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells
Kabir, T.; Connamacher, C. A.; Nadeem, Z.; Paul, M. R.; Smutny, M. R.; Lawler, Z. K.; Djomo, A. M.; Carroll, T.; Gates, L. A.
10.1101/2025.05.07.652677 — cell biology — Posted on 2025-05-13
3422 Tet1 safeguards lineage allocation in intestinal stem cells
Gleizes, A.; Janto, N.; Bombin, S.; Rao, V.; Ari, G.; Sun, S.; Fonseca, M. V.; Gracz, A. D.
10.1101/2025.05.08.652522 — cell biology — Posted on 2025-05-13
3424 The proteostatic landscape of healthy human oocytes
Boke, E.; Zaffagnini, G.; Duran, J. M.; Sole, M.; Polyzos, N. P.
10.1101/2025.05.08.652885 — cell biology — Posted on 2025-05-13
3425 Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy
Rodriques, A.; Liu, G.; Katchman, A. N.; Zakharov, S. I.; Wan, E. Y.; Kalocsay, M.; Eisert, R.; Bradshaw, G. A.; Chen, B.; Yang, L.; Reiken, S.; Liao, X.; Ji, R.; Saadallah, N.; Fanourakis, S.; Topkara, V. K.; Yuan, Q.; Kushner, J.
10.1101/2025.05.08.652977 — cell biology — Posted on 2025-05-13
3430 Painless Nav1.7 mutations reveal function-critical residuesin the outer vestibule and N-terminus
Sarveswaran, N.; Drissi, I.; Shaikh, S.; Nahorski, M.; Cusdin, F.; Linley, J.; Woods, G.
10.1101/2025.05.12.653536 — molecular biology — Posted on 2025-05-13
3432 LOXL2 alleviates post-traumatic knee osteoarthritis and pain
Ali, F.; Raut, R. D.; Choudhury, C.; Chakraborty, A. K.; Del Valle-Ponce De Leon, C.; Mehra, P.; Bais, M. V.
10.1101/2025.05.12.653521 — molecular biology — Posted on 2025-05-13
3433 LOXL2 Deletion Triggers TMJ Osteoarthritis While Overexpression Protects Against NF-κB-Induced Chondrocyte Apoptosis
Raut, R. D.; Choudhury, C.; Ali, F.; Chakraborty, A. K.; Ahmed, M. M.; Del Valle-Ponce De Leon, C.; Modh, H. V.; Mehra, P.; Fan, Y.; Almarza, A.; Bais, M. V.
10.1101/2025.05.12.653519 — molecular biology — Posted on 2025-05-13
3434 SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice
Anderson, K. A.; deSouza, B.; Castellano-Escuder, P.; Lin, Z.; Ilkayeva, O.; Muehlbauer, M. J.; Grimsrud, P.; Hirschey, M.
10.1101/2025.05.12.653532 — molecular biology — Posted on 2025-05-13
3442 Physiological mechanisms underlying coral acclimatization capacity to novel, multi-stressor conditions
Solomon, S. L.; Lippens, C. R.; Mazza, R.; Powell, M. E.; Johnson, K. W.; Suvacarov, S.; Van der Zande, R. M.; Schoepf, V.
10.1101/2025.05.08.652802 — ecology — Posted on 2025-05-12
3443 Proximity proteomics of primary cilia in human hypothalamic neurons
Macarelli, V.; Sroka, T. J.; Hansen, J. N.; Axelsson, U.; Mick, D. U.; Merkle, F. T.
10.1101/2025.05.11.653368 — cell biology — Posted on 2025-05-12
3445 Cerebellar tDCS differentially modulates sensory inputs in somatosensory cortex and cerebellum.
Sanchez-Leon, C. A.; Cordones, I.; Jimenez-Diaz, A.; Cheron, G.; Medina, J. F.; Marquez-Ruiz, J.
10.1101/2025.05.12.653393 — neuroscience — Posted on 2025-05-13
3446 22q11 deletion selectively alters progenitor states and projection neuron identities in the developing cerebral cortex
Rukh, S.; Meechan, D. W.; Siggins, C.; Erwin, Z. D.; Baldo, G.; Peck, A.; Maynard, T. M.; LaMantia, A.-S.
10.1101/2025.05.12.653556 — neuroscience — Posted on 2025-05-13
3449 Low-Cost Screening of Algae for Extreme Tolerance to pH, Temperature, Salinity, and Light
Barbara Saucedo, B.; Kang, K.; May, L.; Gupta, A.; do Espirito Santo, E.; Mayfield, S.; Dutra Molino, J. V.
10.1101/2025.05.12.653396 — microbiology — Posted on 2025-05-12
3451 HENMT1 restricts endogenous retrovirus activity by methylation of 3'-tRNA fragments
Steinberg, J. I.; Sertznig, H.; Desmarais, J. J.; Wilken, J.; Rubio, D.; Peacey, M.; Kinney, J. B.; Schorn, A. J.
10.1101/2025.05.12.650695 — molecular biology — Posted on 2025-05-12
3453 Mycobacterium tuberculosis partitions the Krebs cycle to persist under iron starvation
Serafini, A.; Garza-Garcia, A.; Sorze, D.; de Carvalho, L. P. S.; Manganelli, R.
10.1101/2025.05.12.653400 — microbiology — Posted on 2025-05-12
3454 An intercellular signaling pathway in the mouse retina connects Kv2.1, GLT-1, and nitric oxide synthase 1 to optic nerve regeneration
Gilbert, H.-y.; Li, Y.; Yuki, K.; Omura, K.; Walter, M.; Hanovice, N.; Yin, Y.; Huang, P.; Danbolt, N. C.; Liu, Z.; Tang, J.; Zhang, Q.; Aizenman, E.; Lippard, S. J.; Benowitz, L.; Rosenberg, P. A.
10.1101/2025.05.07.652294 — neuroscience — Posted on 2025-05-12
3455 Liver-Derived, Circulating Xanthine Oxidoreductase Drives Vascular Impairment Associated with Inhalation of Ultrafine Particulates.
Williams, X. M.; Bossert, A. T.; Seman, M.; Lewis, S. E.; McCallen, H.; Pilkerton, J.; Bowdridge, E. C.; Paternostro, M. A.; Goldsmith, W. T.; Nurkiewicz, T. R.; Hussain, S.; Kelley, E. E.; DeVallance, E.
10.1101/2025.05.07.652261 — physiology — Posted on 2025-05-12
3456 Enteropancreatic neurons drive the glucoregulatory response to ingested lipid
Roberts, A. G.; Meyer, L.; Norton, M.; Phuah, P.; Martin Alonso, A.; Dowsett, G. K.; Cheng, S.; Dunsterville, C.; Liu, J.; Chung, P.-E.; Tao, Y.; Smitherman-Cairns, T.; Deutsch, A. B.; Chatterjee, A.; Lam, B. Y.; Hanyaloglu, A.; Jones, B.; Yeo, G. S. H.; Salem, V.; Murphy, K. G.
10.1101/2025.05.09.652620 — physiology — Posted on 2025-05-12
3458 Pregnant Dairy Heifers Express Influenza A Virus Receptors in the Mammary Gland
Baker, P. H.; Glendenning, L. M.; Oliveira, M. X. S.; Cobb, B. A.; Enger, B. D.; Langel, S. N.
10.1101/2025.05.08.652757 — pathology — Posted on 2025-05-12
3459 Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features
Badenoch, B.; Fiehn, O.; Rappaport, N.; Srivastava, P.; Watanabe, K.; Chandrasekaran, S.; Miller, R. A.
10.1101/2025.05.11.651908 — bioinformatics — Posted on 2025-05-12
3460 Efficient evidence-based genome annotation with EviAnn
Zimin, A. V.; Puiu, D.; Pertea, M.; Yorke, J.; Salzberg, S.
10.1101/2025.05.07.652745 — bioinformatics — Posted on 2025-05-12
3461 P3ANUT: An enhanced DNA sequencing analysis platform for uncovering and correcting errors in peptide phage display library screening
Tucker, L.; Kolland, E.; Gooding, J.; Boudjelal, H.; Ahmadipour, S.; Field, R. A.; Warren, D. T.; Baker, D.; Ma, Y.; Marin, M. J.; Wu, T.; Morris, C. J.
10.1101/2025.05.12.648809 — bioinformatics — Posted on 2025-05-12
3467 Structure and inhibition mechanism of the helicase-primase complex from human herpesvirus 1
Sato, K.; Ishida, H.; Miyagishi, T.; Kobayashi, S.; Kise, Y.; Hamada, K.; Okada, C.; Oguni, A.; Nureki, O.; Kono, H.; Fukuzawa, K.; Sengoku, T.
10.1101/2025.05.12.653380 — biochemistry — Posted on 2025-05-12
3468 Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
Kim, J.; Na, H.; Choi, S.-Y.; Oh, E. J.; Lee, H.; Ryu, S. H.; Yunn, N.-O.; Cho, Y.
10.1101/2025.05.12.653381 — biochemistry — Posted on 2025-05-12
3470 Two high-quality rose genomes underpin a novel Rosa pangenome to advance rose genomics, phylogenetics, and breeding
Yang, Z.; Schijlen, E. G. W. M.; Schranz, E.; Zwaan, B. J.; de Ridder, D.; Visser, R. G. F.; Arens, P. F. P.; Smulders, M. J. M.; van Velzen, R.; Keurentjes, J. J. B.; Bourke, P. M.; Smit, S.
10.1101/2025.05.07.652600 — genomics — Posted on 2025-05-12
3472 Unearthing the rhizosphere microbiome recruited by ancestral bread wheat landraces
HERNANDEZ SORIANO, M. C.; Warren, F. J.; Hildebrand, F.; Wingen, L. U.; Miller, A. J.; Griffiths, S.
10.1101/2025.05.08.652585 — ecology — Posted on 2025-05-12
3474 Pln1 Mediates Lipid Droplet-Vacuole Tethering During Microlipophagy Saccharomyces cerevisiae
Monala Rao, J.; Folger, B.; Reus, J.; Toulmay, A.; Li, J.; Zhang, R.; Prinz, W.; Goodman, J.; Wang, F.
10.1101/2025.05.07.652694 — cell biology — Posted on 2025-05-12
3475 Targeting AASS improves neurotoxicity and mitochondrial function in astrocyte models for pyridoxine dependent epilepsy
Schuurmans, I. M. E.; Engelke, U.; Abedrabbo, M.; Puvogel, S.; Mijdam, R.; Scholten, G.-J.; van Katwijk, S. B.; Oudakker, A.; Al-Shekaili, H. H.; Lefeber, D. J.; Leavitt, B. R.; van Karnebeek, C. D. M.; Nadif Kasri, N.; Garanto, A.
10.1101/2025.05.07.652392 — cell biology — Posted on 2025-05-12
3476 RABEP1 amplifies front signaling in neutrophil migration
Kim, D. H.; Syahirah, R.; Zheng, C.; Ding, C.; Liu, S.; Wan, J.; Deng, Q.
10.1101/2025.05.08.652481 — cell biology — Posted on 2025-05-12
3477 Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle delivery
Iyer, S.; Daman, K.; Sun, Y.; Tutto, A.; Holbrook, S.; Joynt, A.; Yan, J.; Ambegaokar, P.; Guo, D.; Liu, P.; Stauffer, J.; Lee, S.; Gallagher, T.; Cox, G. A.; Keeler, A. M.; Siegwart, D. J.; Emerson, C. P.; Wolfe, S. A.
10.1101/2025.05.12.653518 — molecular biology — Posted on 2025-05-12
3478 Structural insights into the remodeled RNA polymerase II complex on an RNA template
Hao, J.; Qin, Z.; Ma, J.; Qu, J.; Wang, Y.; Folimonova, S. Y.; Liu, B.; Li, W.; Wang, Y.
10.1101/2025.05.12.653476 — molecular biology — Posted on 2025-05-12
3479 Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease
Srivastava, S. P.; Zhou, H.; Shenoi, R.; Morris, M.; Lainez-Mas, B.; Takagaki, Y.; Ranjendran, B. K.; Setia, O.; Aryal, B.; Kanasaki, K.; Koya, D.; Inoki, K.; Dardik, A.; Fernandez-Hernando, C.; Shulman, G. I.; Goodwin, J. E.
10.1101/2025.05.08.652142 — molecular biology — Posted on 2025-05-12
3481 Single-cell tracking of genetically minimized Salmonella reveals mechanisms of effector gene cooperation.
Burford, W. B.; Dilabazian, H.; Alto, L. T.; Ma, D. H.; Mobley, A. B.; Farrar, D.; Radhakrishnan, A.; Alto, N. M.
10.1101/2025.05.12.653496 — microbiology — Posted on 2025-05-12
3484 CD33 Epitope Editing Unlocks UM171-Expanded Cord Blood Grafts for AML Immunotherapy
Lehnertz, B.; Langouet, M.; Corneau, S.; MacRae, T.; Joe, M.; Schmidt, E. N.; Spinella, J.-F.; Mayotte, N.; Moore, S.; Tellechea, M. F.; Boivin, I.; Papineau, L.; Rojas-Sutterlin, S.; Tual, M.; Jimenez Cortes, C.; Chagraoui, J.; Tomellini, E.; Desse, V.; Gagnon, E.; Macauley, M. S.; Sauvageau, G.
10.1101/2025.05.07.652621 — immunology — Posted on 2025-05-12
3491 The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.
Ortmayr, K.; Ringwald, M.; Schuhknecht, L.; Dubuis, S.; Paunossis, E.; Blasi, M.; Jehanno, C.; Grieder, S.; Bentires-Alj, M.; Mall, M.; Zampieri, M.
10.1101/2025.05.12.652188 — cancer biology — Posted on 2025-05-12
3494 Sex-Based Transcriptomic Differences in Psoriatic Lesions: A Comprehensive Meta-Analysis
Stemmer, E.; Salmon-Divon, M.; Sinberger, L. A.; Lax, T.; Shrem, G.; Mor, I.; Zahavi, T.
10.1101/2025.05.07.652611 — bioinformatics — Posted on 2025-05-12
3500 Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming
Stock, M.; Guillen-Angel, M.; Witzenberger, M.; Nowak, J.; Biela, A.; Chramiec-Glabik, A.; Mariano, V.; Dreos, R.; Sklias, A.; Quadroni, M.; Brummer, A.; Gallart-Ayala, H.; Ivanisevic, J.; Guex, N.; Kleenman, L.; Leidel, S.; Helm, M.; Bagni, C.; Glatt, S.; Gatfield, D.; Schwartz, S.; Roignant, J.-Y.
10.1101/2025.05.12.653498 — genetics — Posted on 2025-05-12
3502 In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.
Worthington, A. K.; Borges, B.; Lum, T.; Echeverri, E. S.; Zada, F. M.; Cordero, M.; Kim, H.; Zenhausern, R.; Celik, O.; Shaw, C.; Gutierrez-Martinez, P.; Omarova, M.; Blanchard, C.; Burns, S.; Cromer, K.; Dahlman, J.; MacKenzie, T.
10.1101/2025.05.12.652147 — cell biology — Posted on 2025-05-12
3504 Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system
Bai, B.; Li, J.; Wang, Z.; Yang, Y.; He, J.; Chen, G.; Zhang, Y.; Qi, Y.; Wan, Z.; Cai, L.; Wang, R.; Wang, K.; Zhao, D.; Zhang, J.; Huang, W.; Xu, R. X.; Sun, M.; Han, X.; Liu, Y.; Zhang, D.; Zhu, W.; Liu, J.; Guo, Y.
10.1101/2025.05.07.652597 — cell biology — Posted on 2025-05-12
3507 Ureaplasma parvum SMC-ScpAB complex is capable of loop extrusion and demonstrates properties that distinguish it from Bacillus subtilis homologue
Rumyantseva, N. A.; Sapozhnikova, A. P.; Khasanova, A. A.; Zapryagaeva, E. Y.; Kudryavtseva, M. A.; Morozova, N. E.; Vedyaykin, A.
10.1101/2025.05.11.653314 — molecular biology — Posted on 2025-05-12
3510 Identification of host lncRNAs that impact Venezuelan equine encephalitis virus replication
Behnia, M.; Ye, C.; Somfleth, K.; Oyebamiji, O.; Brayer, K.; Guo, Y.; Ness, S.; Savan, R.; Bradfute, S. B.
10.1101/2025.05.12.653438 — microbiology — Posted on 2025-05-12
3511 Cytochrome c oxidase I deep amplicon sequencing for metabarcoding of equine strongyle communities: unexpectedly high Strongylus spp. burden in treated horses
Krücken, J.; Diekmann, I.; Andreotti, S.; Bredtmann, C. M.; Mbedi, S.; Sparmann, S.; Schmidt, J. S.; de Almeida Borges, F.; de Freitas, M. G.; Salle, G.; Hofer, H.; Matthews, J. B.; Tzelos, T.; Nielsen, M. K.; Kuzmina, T. A.; von Samson-Himmelstjerna, G.
10.1101/2025.05.12.653446 — microbiology — Posted on 2025-05-12
3513 Prevalence, Production and the Role of Staphylococcus aureus Superantigens in Cystic Fibrosis Lung Disease.
Sun, Y.; Hu, B.; Chhabra, S.; Tolentino, J.; Suzuki, N.; Natarajan, J.; Harris, Z.; Stanley, G.; Bianco, C.; Planet, P. J.; Sherchand, S. P.; Adhikari, R.; Aman, J.; Zhang, X.; Koff, J. L.; Rajagopalan, G.
10.1101/2025.05.07.652658 — immunology — Posted on 2025-05-12
3514 Tissue resident memory T cells populate the human uveal tract
Foers, A. D.; Reekie, I. R.; Wickramasinghe, L.; Ward, A.; Buckley, T. M.; Attar, M.; Aguilar-Munoa, S.; Pilapil, Q.; Abdalla Elsayed, M. E.; Pledger, S.; Bhalla, A.; Hedley, R.; Hill, S.; Windell, D.; Barton, K.; Masood, I.; Lim, K. S.; Coles, M. C.; Sherlock, J. P.; Dick, A. D.; Coupland, S. E.; Sansom, S. N.; Copland, D. A.; Buckley, C. D.; Sharma, S. M.; ORBIT Consortium,
10.1101/2025.05.07.652385 — immunology — Posted on 2025-05-12
3516 Population-Level Activity Dissociates Preparatory Overt from Covert Attention
Koevoet, D.; Voet, V.; Jones, H. M.; Awh, E.; Strauch, C.; Van der Stigchel, S.
10.1101/2025.05.07.652629 — neuroscience — Posted on 2025-05-12
3522 Ex vivo recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human Lymphoid Follicle Chip platform
Zhai, Y.; Ku, M. W.; Yang, K.; Patil, A.; Prabhala, P.; He, L.; Man, Y.; Spörri, S. B.; Gharpure, S.; Isaacs, A. R.; Ferdosi, S.; Pitek, A.; Maruggi, G.; Bertholet, S.; Firestone, J.; Mousavi, K.; Miller, E.; Luisi, K.; Hellman, C. A.; Williams, L. D.; Tomaras, G. D.; Yin, P.; Gygi, S.; McAuliffe, J.; Ingber, D. E.; Goyal, G.
10.1101/2025.04.16.649172 — immunology — Posted on 2025-05-12
3523 Mesolimbic dopamine ramps reflect environmental timescales
Floeder, J. R.; Jeong, H.; Mohebi, A.; K Namboodiri, V. M.
10.1101/2024.03.27.587103 — neuroscience — Posted on 2025-05-12
3524 Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown
Paterson, T.; Rohrs, J.; Hohman, T. J.; Mapstone, M.; Meikle, P.; Kaddurah-Daouk, R.; Levey, A. I.; Hood, L.; Funk, C. C.
10.1101/2024.07.23.604835 — neuroscience — Posted on 2025-05-12
3526 Zebrafish as a model to study PERK function in developmental diseases: implications for Wolcott-Rallison syndrome
Almeida, L. M.; Lima, L. P.; Oliveira, N. A. S.; Silva, R. F. O.; Sousa, B.; Bessa, J.; Pinho, B. R.; Oliveira, J. M. A.
10.1101/2024.04.16.589737 — pharmacology and toxicology — Posted on 2025-05-12
3528 Opposing Nodal and Wnt signalling activities govern the emergence of the mammalian body plan
Dias, A.; Pascual-Mas, P.; Robertson, G.; Torregrosa-Cortes, G.; Stelloo, S.; Casani-Galdon, P.; Babin, S.; Romaniuk, Y.; Mayran, A.; Wehmeyer, A. E.; Garcia-Ojalvo, J.; McNamara, H. M.; Vermeulen, M.; Arnold, S. J.; Martinez Arias, A.
10.1101/2025.01.11.632562 — developmental biology — Posted on 2025-05-12
3529 Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency
Seo, S.; Ahn, Y.-O.; Patil, S. L.; Armetta, J.; Saturne, M. D.; Hegewisch-Solloa, E.; Guilz, N. C.; Patel, A.; Corneo, B.; Borowiak, M.; Mace, E. M.
10.1101/2023.09.25.559149 — cell biology — Posted on 2025-05-12
3530 An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks
Cattle, M. A.; Aguado, L. C.; Sze, S.; Wang, D. Y.; Papagiannakopoulos, T.; Smith, S.; Rice, C. M.; Schneider, W. M.; Poirier, J. T.
10.1101/2024.08.05.606586 — molecular biology — Posted on 2025-05-12
3532 Commensal bacteria inhibit viral infections via a tryptophan metabolite
Jiang, D.; Soo, N.; Tan, C. Y.; Dankwa, S.; Wang, H.-Y.; Theriot, B. S.; Xue, K.; Hill, D.; Ardeshir, A.; Bain, J. R.; Heston, S. M.; Hurst, J. H.; Siddiqui, N. Y.; Van Rompay, K. K. A.; Cervantes-Barragan, L.; Smith, J. P.; Song, R.; Roper, J.; Kelly, M. S.; Hudgens, M. G.; De Paris, K.; Permar, S. R.; Goswami, R.; Surana, N. K.
10.1101/2024.04.21.589969 — microbiology — Posted on 2025-05-12
3534 Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use
Barekat, K.; Ghosh, S.; Herrmann, C.; Keat, K.; Assenmacher, C.-A.; Tanes, C.; Wilson, N.; Sengupta, A.; Das, U. S.; Joshi, R.; Ritchie, M.; Bittinger, K.; Weljie, A.; Cadwell, K.; Bushman, F.; Wu, G.; FitzGerald, G. A.; Ricciotti, E.
10.1101/2024.11.22.624882 — pharmacology and toxicology — Posted on 2025-05-12
3542 Aird-MSI: a high compression rate and decompression speed format for mass spectrometry imaging data
Li, S.; Sheng, H.; Du, P.; Chen, J.; Wang, X.; Tong, J.; Hong, J.; Jing, X.; Lu, M.; Yu, C.
10.1101/2025.05.07.652785 — bioinformatics — Posted on 2025-05-12
3544 Modelling PRRS transmission between pig herds in Denmark and prediction of interventions impact
Chang, Y.; Marques, A. R. P.; Fertner, M.; Toft, N.; Lorenzen, B.; Reimert, M. M.; Houe, H.; Conrady, B.
10.1101/2025.05.09.653077 — ecology — Posted on 2025-05-12
3545 Long non-coding RNA hsr-omega provides scaffolding for the nuclear domain B-body.
An, S.; Haque, S. N.; Adams, M.; Rodriguez, L. E. T.; Kiani, K.; Bryantsev, A.
10.1101/2025.05.07.652789 — cell biology — Posted on 2025-05-12
3547 Poor sleep impairs immune responses and influenza vaccine protection
Guan, M.; Gu, W.; Abdelnaby, K.; Balamalaliyage, P.; Tunterak, W.; Li, M.; Wen, Y.; Driver, J.; Gozal, D.; Wan, X.-f.
10.1101/2025.05.07.652783 — immunology — Posted on 2025-05-12
3548 3BTRON: A Blood-Brain Barrier Recognition Network
Fletcher-Lloyd, N. V.; Bravo-Ferrer, I.; Gaasdal-Bech, K.; Diaz Castro, B.; Barnaghi, P.
10.1101/2025.02.12.637854 — neuroscience — Posted on 2025-05-12
3550 Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence
Hawes, S.; Liang, B.; Oldham, B.; Sullivan, B. T.; Song, B.; Chang, L.; Wang, L.; Lin, D.-T.; Cai, H.
10.1101/2025.02.28.640838 — neuroscience — Posted on 2025-05-12
3551 Ciliary ARL13B is essential for body weight regulation in adult mice
Terry, T. T.; Gigante, E. D.; Alexandre, C. M.; Brewer, K. M.; Yue, X.; Berbari, N. F.; Vaisse, C.; Caspary, T.
10.1101/2023.08.02.551695 — genetics — Posted on 2025-05-12
3553 Vancomycin-resistant enterococci colonise the antibiotic-treated intestine by occupying overlapping but distinct nutrient- and metabolite-defined intestinal niches
King, O. G.; Yip, A. Y. G.; Horrocks, V.; Miguens Blanco, J.; Marchesi, J. R.; Mullish, B. H.; Clarke, T. B.; McDonald, J. A. K.
10.1101/2024.12.12.628149 — microbiology — Posted on 2025-05-12
3556 A human-specific regulatory mechanism revealed in a preimplantation model
Fueyo, R.; Wang, S.; Crocker, O. J.; Swigut, T.; Nakauchi, H.; Wysocka, J.
10.1101/2025.05.10.653263 — developmental biology — Posted on 2025-05-12
3564 Bridging 3D Molecular Structures and Artificial Intelligence by a Conformation Description Language
Xiong, J.; Shi, Y.; Zhang, W.; Zhang, R.; Chen, Z.; Zeng, C.; Jiang, X.; Cao, D.; Xiong, Z.; Zheng, M.
10.1101/2025.05.07.652440 — bioinformatics — Posted on 2025-05-12
3566 Targeting C42 in PKGIα alleviates diastolic dysfunction in HFpEF
Su, J.; Zhang, M.; Yang, X.; Holt, M.; Raabe, J.; Cuello, F.; Shah, A. M.; Shattock, M. J.; Burgoyne, J. R.
10.1101/2025.05.09.653217 — biochemistry — Posted on 2025-05-12
3567 Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model
Usiello, A.; Arisumi, K.; Nuzzo, T.; Gilio, L.; Taniguchi, S.; Russo, R.; Motegi, H.; di Vito, R.; Hata, J.; Errico, F.; Hashiguchi, A.; Okano, H.; Furlan, R.; Finardi, A.; Bassi, M. S.; Nakahara, J.; Mita, M.; Kanai, T.; Chambery, A.; Yasui, M.; Centonze, D.; Sasabe, J.
10.1101/2025.05.07.652561 — neuroscience — Posted on 2025-05-12
3569 Cap-adjacent 2'-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1
Clemens, E.; Brivio, S.; Al-Khafaji, M.; Eijlers, P.; Kurukulasuriya, M.; MacLeod, D.; Haussmann, I.; Wenzel, M.; Mueller, B.; Soller, M.; Pettitt, J.
10.1101/2025.03.10.638824 — molecular biology — Posted on 2025-05-12
3570 Mapping the loss of flagellar motility across the tree of life
Philip, J. S.; Grewal, S.; Scadden, J.; Puente Lelievre, C.; Matzke, N. J.; McNally, L.; Baker, M. A.
10.1101/2024.12.05.626484 — microbiology — Posted on 2025-05-12
3573 A functionally validated TCR-pMHC database for TCR specificity model development
Messemaker, M.; Kwee, B. P. Y.; Moravec, Z.; Alvarez-Salmoral, D.; Urbanus, J.; de Paauw, S.; Geerligs, J.; Voogd, R.; Morris, B.; Guislain, A.; Mussmann, M.; Winkler, Y.; Steinmetz, M.; Iras, M.; Marcus, E.; Teuwen, J.; Perrakis, A.; Beijersbergen, R. L.; Scheper, W.; Schumacher, T.
10.1101/2025.04.28.651095 — immunology — Posted on 2025-05-12
3576 Direct quantitative assessment using digital droplet PCR and field-scale spatial distribution of Plasmopara viticola oospores in vineyard soil
Poeydebat, C.; Courchinoux, E.; Demeaux, I.; Rodriguez, M.; Chataigner, A.; Lelievre, M.; Goutouly, J.-P.; Rossi, J.-P.; Raynal, M.; Deliere, L.; Francois, D.
10.1101/2024.07.29.605284 — plant biology — Posted on 2025-05-12
3577 Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes
Yang, J.; de Oliveira Pessoa, D.; Ryniawec, J. M.; Coope, M. R.; Buster, D. W.; Loertscher, E.; Wang, M.; Chen, C.; Cress, A. E.; Rogers, G. C.; Padi, M.
10.1101/2025.05.10.653266 — cancer biology — Posted on 2025-05-12
3578 Uromodulin velcro sheets and their interaction with uropathogenic E. coli
Banjara, S.; Wang, H.; Schaeffer, C.; Stsiapanava, A.; Sandin, S.; Carroni, M.; Okumura, H.; Rampoldi, L.; Sandblad, L.; Jovine, L.
10.1101/2025.05.09.653020 — biophysics — Posted on 2025-05-12
3579 Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment
Zaza, C.; Joseph, M. D.; Dalby, O. P. L.; Walther, R. F.; Kolataj, K.; Chiarelli, G.; Pichaud, F.; Acuna, G. P.; Simoncelli, S.
10.1101/2024.08.26.609760 — biophysics — Posted on 2025-05-12
3583 Powerful one-dimensional scan to detect heterotic QTL
Li, G.; Schmidt, R. H.; Zhao, Y.; Reif, J. C.; Jiang, Y.
10.1101/2025.05.06.652159 — genetics — Posted on 2025-05-12
3585 Endosymbionts impact ladybird predation rates of aphids in a temperature-dependent manner
Bitsch, K.; Ross, P. A.; Gill, A.; Yang, Q.; Stelmach, M.; Callahan, A.; Oersted, M.; Hoffmann, A. A.; Kristensen, T. N.
10.1101/2024.09.20.614137 — ecology — Posted on 2025-05-12
3586 Elevated mitochondrial metabolism in Down syndrome iPSCs reduces commitment to neuroectoderm
Rothermel, B. A.; Chaklader, M.; Souza Bomfim, G. H.; Jeju, N.; Duan, Y.; Niemeyer, B. F.; Espinosa, J. M.; Rosado-Olivieri, E.; Lin, W.; Lacruz, R. S.
10.1101/2025.05.09.653211 — developmental biology — Posted on 2025-05-12
3587 Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona
Hozumi, A.; Totsuka, N. M.; Onodera, A.; Wang, Y.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Hotta, K.; Sasakura, Y.
10.1101/2024.04.09.588679 — developmental biology — Posted on 2025-05-12
3589 miR-486-3p ameliorates aging-related impaired angiogenesis in adult moyamoya disease by targeting Forkhead Box O4
Chen, J.; Wen, Y.; Chen, S.; Long, T.; Chen, F.; Wang, Z.; Zhang, G.-Z.; Li, M.; Zhang, S.; Kang, H.; Feng, W.; Wang, G.
10.1101/2025.05.07.652777 — molecular biology — Posted on 2025-05-12
3590 Novel origin of replication for environmentally isolated Pantoea strain enables expression of heterologous proteins, pathways and products
Codik, A.; Kothari, A.; Liu, H.; Weinberg, B. L.; Owens, T. K.; Srinivasan, A.; Rivier, A.; Eng, T.; Arkin, A. P.; Deutschbauer, A. M.; Mukhopadhyay, A.
10.1101/2025.05.10.653210 — microbiology — Posted on 2025-05-12
3591 Phosphorylation of the α subunit inhibits proteasome assembly and regulates cell division in archaea
Huang, Q.; Wu, Y.; Gan, Q.; Liang, S.; Yang, Y.; Wu, P.; Feng, X.; She, Q.; Ni, J.; Shen, Y.
10.1101/2025.05.09.653063 — microbiology — Posted on 2025-05-12
3592 Promising Inhibitor of Flavivirus: Evaluating the Antiviral Activity of Nordihydroguaiaretic Acid against West Nile Virus Replication
Martinez, F.; Ghietto, L. M.; Lingua, G.; Aguilar, J. J.; Gil, P. I.; Gomez, T. I.; Marioni, J.; Nunez-Montoya, S. C.; Konigheim, B.
10.1101/2025.05.10.653272 — microbiology — Posted on 2025-05-12
3594 Psilocybin-induced modulation of visual salience processing
Muller, S. A.; Cavanna, F.; de la Fuente, L. A.; Bruno, N.; D'Amelio, T.; Pallavicini, C.; Tagliazucchi, E.
10.1101/2025.05.10.652897 — neuroscience — Posted on 2025-05-12
3597 Neural Mechanisms Supporting Proactive Control
Feldman, R. L.; Quale, M.; Etzel, J. A.; Braver, T. S.
10.1101/2025.05.09.653198 — neuroscience — Posted on 2025-05-12
3599 Hippocampal reactivation of planned trajectories is required for effective goal choice in an allocentric memory task
Gobbo, F.; Mitchell-Heggs, R.; Duszkiewicz, A. J.; Tse, D.; Garcia-Font, N.; Faillace, E.; Spooner, P. A.; Keshishian, A.; Schnitzer, M. J.; Schultz, S. R.; Morris, R. G.
10.1101/2025.05.10.653115 — neuroscience — Posted on 2025-05-12
3602 BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons
Gazal, N. G.; Castellanos-Montiel, M. J.; Bruno, G.; Franco-Flores, A. K.; Lepine, S.; Gursu, L.; Haghi, G.; Maussion, G.; Anastasia, A.; Bisbal, M.; Gorostiza, E. A.; Durcan, T. M.; Unsain, N.
10.1101/2025.05.09.653215 — neuroscience — Posted on 2025-05-12
3604 Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin
Mimoso, T.; Korobeinikov, A.; Stein, A.; Milovanovic, D.; Rizzoli, S. O.; Köster, S.; Reshetniak, S.
10.1101/2025.05.08.652815 — neuroscience — Posted on 2025-05-12
3605 Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns
Speckert, A.; Gianinazzi, L.; Kollmorgen, S.; Hagmann, C.; Grehten, P.; Kottke, R.; Natalucci, G.; Latal, B.; Knirsch, W.; Tuura, R.; Spina Bifida Study Group Zurich, ; Hoefler, T.; Jakab, A.
10.1101/2025.05.08.652584 — neuroscience — Posted on 2025-05-12
3608 LINKING MULTI-SCALE BRAIN CONNECTIVITY WITH VIGILANCE, WORKING MEMORY, AND BEHAVIOR IN ADOLESCENTS
Bajracharya, P.; Ballem, R.; Chen, J.; Camazon, P. A.; Khasayeva, N.; Calhoun, V.; Liu, J.; Iraji, A.
10.1101/2025.05.09.653144 — neuroscience — Posted on 2025-05-12
3609 Resting state periodic and aperiodic brain oscillations from birth to preschool years: Aperiodic maturity predicts developmental course
Green, H. L.; Edgar, J. C.; Mol, K.; McNamee, M.; Prosser, L.; Kim, M.; Kuschner, E. S.; Miller, G. A.; Chen, Y.
10.1101/2025.05.11.653151 — neuroscience — Posted on 2025-05-12
3610 Could instructor talk drive CURE effectiveness? A comparative study of instructor talk in introductory lab courses
Zajic, C. J.; Subramanian, K.; Adulla, A.; Allen, Z.; Blitchington, M. B.; Brotzman, A.; Carrillo, E.; Dhruv, J.; Evans, T.; Haider, S.; Han, S. A.; Hilton, L.; Holliday, K.; Keairnes, E.; Kum, J.; Lantz, W. N.; Martin, J.; Pierce-Tomlin, M.; Plunkett, M. J.; Sam, C. S.; Sarr, F.; Shroyer, A.; Tucker, C.; Walton, K.; West, M. A.; Wolfson, E.; Yoon, B.; Zumbro, K.; Dolan, E. L.
10.1101/2025.05.09.653137 — scientific communication and education — Posted on 2025-05-12
3611 An All-In-One Software Solution for Automated Processing of LA-ICP-TOF-MS datasets
Crawford, A. M.; Zee, D. Z.; Jin, Q.; Sue, A.; Sinha, N.; Ahn, S. H.; MacRenaris, K. W.; O'Halloran, T.
10.1101/2025.05.09.653091 — scientific communication and education — Posted on 2025-05-12
3612 A phrenic-sparing cephalic reanastomosis model: Acute effects and implications
Lebenstein-Gumovski, M.; Zharchenko, A.; Rasueva, T.; Sobol, E.; Petrov, P.; Eskov, K.
10.1101/2025.05.06.652103 — bioengineering — Posted on 2025-05-12
3613 Modelling PRRS transmission between pig herds in Denmark and prediction of interventions impact
Chang, Y.; Marques, A. R.; Fertner, M.; Toft, N.; Lorenzen, B.; Reimert, M. M.; Houe, H.; Conrady, B.
10.1101/2025.05.09.653077 — ecology — Posted on 2025-05-12
3616 Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium
Han, L. K. M.; Toenders, Y. J.; Shen, X.; Milaneschi, Y.; Whalley, H. C.; Saemann, P. G.; Andlauer, T. F. M.; Bauer, J.; Berger, K.; Borgers, T.; Cole, J. H.; Dannlowski, U.; Flinkenfluegel, K.; Grabe, H. J.; Grotegerd, D.; Gruber, O.; Hahn, T.; Hamilton, P. J.; Hatton, S. N.; Hermesdorf, M.; Hickie, I.; Homann, J.; Kircher, T. T. J.; Kraemer, B.; Kraus, A.; Krug, A.; Lill, C. M.; Medland, S. E.; Meinert, S.; Panzenhagen, A. C.; Penninx, B. W. J. H.; van der Wee, N. J. A.; van Tol, M.-J.; Volker, U.; Volzke, H.; Weihs, A.; Wittfeld, K.; Thomopoulos, S. I.; Jahanshad, N.; Thompson, P. M.; Pozzi
10.1101/2025.05.09.653064 — neuroscience — Posted on 2025-05-11
3617 Structural Covariance Network Properties Predictive of Early Adolescent Alcohol Initiation
Byrne, H.; Visontay, R.; Devine, E. K.; Wade, N. E.; Jacobus, J.; Squeglia, L. M.; Mewton, L.
10.1101/2025.05.08.652983 — neuroscience — Posted on 2025-05-11
3619 Supra-resonant wingbeats in insects
Wold, E.; Yang, R.; Lynch, J.; Liu, E.; Gravish, N.; Sponberg, S.
10.1101/2025.05.07.652680 — zoology — Posted on 2025-05-11
3621 Magnetic Resonance Imaging for Improved Brain Tumor Detection
Benyard, B. A.; Soni, N.; Swain, A.; Srivastava, N.; Khokhar, S.; Yehya, N.; Fan, Y.; Kumar, D.; Nanga, R. P. R.; Frenneaux, M. P.; Haris, M.; Reddy, R.
10.1101/2025.05.06.652446 — bioengineering — Posted on 2025-05-11
3624 Mapping global fisheries climate risks to guide sustainable marine management
Faith, M. P.; Atkinson, A.; Heneghan, R. F.; Ostle, C.; Fernandes-Salvador, J. A.; Thompson, M. S. A.; Serra-Pompei, C.; Artioli, Y.; Schmidt, K.; Rees, S.; Holland, M.; McQuatters-Gollop, A.
10.1101/2025.05.07.652593 — ecology — Posted on 2025-05-11
3625 Shifting baselines increase the risk of misinterpreting biodiversity trends
Dellavalle, A.; Devenish, A. J. M.; Jarrett, C.; Annorbah, N. N. D.; Asamoah, A.; Boafo, K.; Lane, P. E.; Owen, J.; Morel, A. C.; Hulme, M. F.; Welch, A. J.; Norris, K.; Sanderson, F. J.; Tobias, J.
10.1101/2025.05.07.652594 — ecology — Posted on 2025-05-11
3626 The Freshwater Sounds Archive
Greenhalgh, J. A.; Akmentins, M.; Boullhesen, M.; Brejao, G. L.; Bowman, J. C.; Briers, R. A.; Campbell, k.; Clark, A.; Coen, M.; Desjonqueres, C.; Gaston, S.; Gottesman, B. L.; Jones, I. T.; Lahoz-Monfort, J. J.; Lindsay, E.; Rodriguez, F. M.; Navarrete-Mier, F.; Norton, M.; Las Casas e Novaes, M. C.; Okazaki, S.; Polajnar, J.; Ribeiro, M. C.; Roberts, L.; Rothenberg, D.; Sabet, S. S.; Satish, R.; Spriel, B.; Stankovic, D.; Velde, K. t.; Timperley, J. H.; Turlington, K.; Walker, J. R.; Valverde, M. P.; Cox, K.; Looby, A.
10.1101/2025.05.07.652412 — ecology — Posted on 2025-05-11
3629 Urban bats change the menu: dietary plasticity across human-modified landscapes of a tropical island
Dietrich, M.; Wilkinson, D. A.; Le Minter, G.; Turpin, M.; Galan, M.; Charbonnel, N.; Dupuy, G.; Habchi-Hanriot, N.; Reynaud, B.; Delatte, H.; Lebarbenchon, C.
10.1101/2025.05.06.652573 — ecology — Posted on 2025-05-11
3634 Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting
Kumar, A.; Sanders, M.; Zhang, H.; Zhou, L.; Parveen, S.; Kelly, C. V.; Granneman, J. G.; Huang, Y.-m.
10.1101/2025.05.06.652485 — biophysics — Posted on 2025-05-11
3639 Characteristics predicting reduced penetrance variants in the high-risk cancer predisposition gene TP53
Fortuno, C.; Richardson, M. E.; Pesaran, T.; McGoldrick, K.; James, P. A.; Spurdle, A. B.
10.1101/2025.05.06.652567 — genetics — Posted on 2025-05-11
3640 Long-lasting coexistence of multiple asexual lineages alongside their sexual counterparts in a fungal plant pathogen
Abdalrahem, A.; Andrieux, A.; Becheler, R.; Duplessis, S.; Frey, P.; Marcais, B.; Stoeckel, S.; Halkett, F.
10.1101/2025.03.28.645883 — evolutionary biology — Posted on 2025-05-11
3643 Protection of double-Holliday junctions ensures crossing over during meiosis
Tang, S. M.; Hariri, S.; Bohn, R.; McCarthy, J. E.; Koo, J.; Pourhosseinzadeh, M.; Nguyen, E.; Liu, N.; Ma, C.; Lu, H.; Lee, M.; Hunter, N.
10.1101/2024.09.14.613089 — cell biology — Posted on 2025-05-11
3644 Unveiling Genomic Rearrangements in Engineered iPSC Lines by Optical Genome Mapping
Finlay, D.; Hor, P.; Goldenson, B. H.; Li, X.-H.; Murad, R.; Kaufman, D. S.; Vuori, K.
10.1101/2025.05.10.653237 — molecular biology — Posted on 2025-05-11
3646 Peptide Driven Identification of TCRs (PDI-TCR) reveals dynamics and phenotypes of CD4 T cells in tuberculosis
Tippalagama, R.; Trevizani, R.; Chihab, L.; Chawla, A.; Fung, K.; Greenbaum, J.; Kearns, K.; De Silva, A.; Gunasinghe, W.; Perera, J.; Gunasekera, H.; Senevirathne, D.; Scriba, T.; Sette, A.; Arlehamn, C. L.; Burel, J.; Peters, B.
10.1101/2025.05.06.652535 — immunology — Posted on 2025-05-11
3647 HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis.
Brown, K.; Walsh, A.; Yennemadi, A. S.; Murphy, D. M.; Conolly, S.; O'Sullivan, M. P.; Basdeo, S.; O'Leary, S.; Leisching, G.; Keane, J.
10.1101/2025.05.09.653039 — immunology — Posted on 2025-05-11
3648 Idebenone Enhances the Early Microglial Response to Traumatic Brain Injury and Mitigates Acute Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways
Hwang, H.; Sarkar, C.; Piskoun, B.; Zhang, N.; Borcar, A.; Robertson, C. L.; Lipinski, M. M.; Yadava, N.; Goodfellow, M. J.; Polster, B. M.
10.1101/2025.05.06.652467 — neuroscience — Posted on 2025-05-11
3649 Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period
Pillutla, S. V.; Skoda, M. J.; Ishii, A.; Corenblum, M. J.; Montgomery, T.; Wene, P. V.; Menakuru, N.; Kraszewski, J. N.; Billheimer, D.; Winter, G. M.; Cowen, S.; Madhavan, L.
10.1101/2025.05.06.652460 — neuroscience — Posted on 2025-05-11
3651 Histology to MRI registration quality of ex vivo human brain blocks fixed with solutions used in anatomy laboratories
Frigon, E.-M.; Gerin-Lajoie, A.; Fouquet, J. P.; Zeighami, Y.; Boire, D.; Dadar, M.; Maranzano, J.
10.1101/2025.05.06.652445 — neuroscience — Posted on 2025-05-11
3655 Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health
Rowsthorn, E.; Sim, M. A.; O'Brien, W. T.; McDonald, S. J.; Franks, K.; Sinclair, B.; Chong, T. T.- J.; Yiallourou, S.; Cavuoto, M.; Vivash, L.; O'Brien, T. J.; Shao, X.; Wang, D. J. J.; Law, M.; Harding, I. H.; Pase, M. P.
10.1101/2025.05.06.652544 — neuroscience — Posted on 2025-05-11
3657 Kinesin-1 Autoinhibition Tunes Cargo Transport by Motor Ensembles
Bensel, B. M.; Previs, S. B.; Fagnant, P. M.; Trybus, K. M.; Walcott, S.; Warshaw, D. M.
10.1101/2025.05.06.652443 — biophysics — Posted on 2025-05-11
3658 Uromodulin velcro sheets and their interaction with uropathogenic E. coli
Banjara, S.; Wang, H.; Schaeffer, C.; Stsiapanava, A.; Sandin, S.; Carroni, M.; Okumura, H.; Rampoldi, L.; Sandblad, L.; Jovine, L.
10.1101/2025.05.09.653020 — biophysics — Posted on 2025-05-11
3662 Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver
Tong, C. Y.; Li, C.; Hurni, C.; Jacq, A.; Nie, X. Y.; Guy, C. R.; Suh, J. H.; Wong, R. K. W.; Merlin, C.; Naef, F.; Menet, J. S.; Jiang, Y.
10.1101/2025.04.03.647044 — bioinformatics — Posted on 2025-05-11
3663 Actin Branching Regulates Cell Spreading and Force on Talin, but not Activation of YAP
Villalobos, C.; Sadeghifar, A.; Maggiorani, J.; Delapena, J.; McDaniel, G.; Driscoll, T. P.
10.1101/2025.05.09.653153 — bioengineering — Posted on 2025-05-11
3664 Discovery of a DNA-based Optical Nanotube Sensor for Glucose Using Clustering and Deep Learning Algorithms
Rabbani, Y.; Bregy, J.; Rousseau, B.; Sajjadi, S. H.; De Benedittis, L.; Behjati, S.; Mouhib, M.; Dehury, S.; Boghossian, A.
10.1101/2025.05.06.652529 — bioengineering — Posted on 2025-05-11
3666 DNA Wrapping by a Tetrameric Bacterial Histone
Hu, Y.; Schwab, S.; Qiu, K.; Zhang, Y.; Baer, K.; Reichle, H.; Panzera, A.; Lupas, A. N.; Hartmann, M. D.; Dame, R. T.; Alva, V.; Alvarez, B. H.
10.1101/2025.05.08.652872 — biochemistry — Posted on 2025-05-11
3667 Constructing a consensus serum metabolome
Chi, Y.; Mitchell, J.; Thapa, M.; Zheng, S.; Frohock, Z.; Li, Y.; Smirnov, A.; Du, X.; Li, S.
10.1101/2025.05.07.652782 — biochemistry — Posted on 2025-05-11
3673 UNCOVERseq Enables Sensitive and Controlled Gene Editing Off-Target Nomination Across CRISPR-Cas Modalities and Systems
Kinney, K. J.; Jia, K.; Zhang, H.; Schmaljohn, E.; Osborne, T.; Thommandru, B.; Murugan, K.; Sanchez-Pena, A.; West, S.; Chen, S.; Codipilly, R.; Sturgeon, M.; Turk, R.; McNeill, M.; Behlke, M.; Jacobi, A. M.; Cromer, K.; Kurgan, G.
10.1101/2025.05.09.653165 — molecular biology — Posted on 2025-05-11
3677 Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase
Barbuti, M. D.; Skjennum, E. F.; Mebus, V. H.; Morales Angeles, D.; Hustad, M.; Marli, M. T.; Frees, D.; Kjos, M.
10.1101/2025.05.11.653310 — microbiology — Posted on 2025-05-11
3678 TurbOmics: a web-based platform for the analysis of metabolomics data using a multi-omics integrative approach
Barrero-Rodriguez, R.; Rodriguez, J. M.; Naake, T.; Huber, W.; Juarez-Fernandez, M.; R. Ramiro, A.; Vazquez, J.; Mastrangelo, A.; Ferrarini, A.
10.1101/2025.05.09.653072 — bioinformatics — Posted on 2025-05-11
3679 De novo design of peptides localizing at the interface of biomolecular condensates
Schneider, T. N.; Gil-Garcia, M.; Buehler, M. A.; Santos, L. F.; Faltova, L.; Guillen-Gosalbez, G.; Arosio, P.
10.1101/2025.05.09.653111 — biochemistry — Posted on 2025-05-11
3681 Time-resolved effects of cold atmospheric plasma on E. coli GW-AmxH19 transcriptome and proteome in an emulated wastewater environment
Zühlke, D.; Bernhardt, J.; Schneider, D.; Rielicke, J.; Sievers, S.; Hahn, V.; Bömeke, M.; Poehlein, A.; Albrecht, D.; Kolb, J. F.; Riedel, K.; Daniel, R.
10.1101/2025.05.08.652849 — microbiology — Posted on 2025-05-11
3682 Structural Covariance Network Properties Predictive of Early Adolescent Alcohol Initiation
Byrne, H.; Visontay, R.; Devine, E. K.; Wade, N. E.; Jacobus, J.; Squeglia, L. M.; Mewton, L.
10.1101/2025.05.08.652983 — neuroscience — Posted on 2025-05-11
3684 Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activation
Bello-Arroyo, E.; Rubio, B.; Mora, A.; Lopez-Olaneta, M.; Gomez-Salinero, J. M.; Ramos, L.; Sanchez-Cabezudo, C. G.; Camafeita, E.; Cusso, L.; Desco, M.; Joffin, N.; Le Coq, J.; Boskovic, J.; McGurk, K. A.; Ware, J. S.; Barton, P. J.; Vazquez, J.; Scherer, P. E.; Sabio, G.; Gomez-Gaviro, M. V.; Lara-Pezzi, E.
10.1101/2025.05.09.653054 — physiology — Posted on 2025-05-11
3685 Evaluating transboundary connectivity to support cross-border conservation between Canada and the United States
O'Brien, P.; Tapper, S.; Brown, M. G. C.; Brennan, A.; Mubareka, S.; Pither, R.; Bowman, J.
10.1101/2025.05.08.652483 — ecology — Posted on 2025-05-11
3689 Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation
Soto-Moreno, E. J.; Ali, N. N.; Kuller, F.; Nasufovic, V.; Frolikova, M.; Tepla, O.; Masata, J.; Trauner, D.; Patterson, A. A.; Arndt, H.-D.; Komrskova, K.; Zernicka-Goetz, M.; Glover, D. M.; Balboula, A. Z.
10.1101/2025.05.07.652730 — cell biology — Posted on 2025-05-11
3690 Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance
Liu, Y.; Bondarenko, A.; Zhang, H.; Luan, P.; Zhang, Q.; Wang, B.; Najam, S. S.; Liang, X.; Syed, A. A. S.; Sirakawin, C.; Lin, D.; Huang, S.; Konovalov, R.; Konopka, W.; Zhang, Z.; Zhang, Y.; Wu, S.; Jing, M.; Vinnikov, I. A.
10.1101/2024.07.02.601503 — neuroscience — Posted on 2025-05-11
3696 Enhancer-driven regulatory network of forebrain human development provides insights into autism
Jourdon, A.; Mariani, J.; Natu, A.; Wu, F.; Li, B.; Capauto, D.; Hagy, K. T.; Norton, S.; Tomasini, L.; Safi, A.; Amiri, A.; Schreiner, J.; Nguyen, C. K.; Nolan, N.; Nelson, M. P.; Ramos, D. M.; Ward, M. E. E.; Szekely, A.; McPartland, J. C.; Pelphrey, K.; Ventola, P.; Chawarska, K.; Gersbach, C. A.; Crawford, G. E.; Abyzov, A.; Vaccarino, F. M.
10.1101/2023.09.06.555206 — genomics — Posted on 2025-05-11
3697 When less is not more: Limits to the evolution of metabolic dependence in spatially structured microbial communities
Ramesh, D.; Fara, E.; Oschmann, F.; Ugolini, G. S.; Stocker, R.; van Vliet, S.; Ackermann, M.; Schubert, O. T.
10.1101/2025.05.09.651753 — evolutionary biology — Posted on 2025-05-11
3698 EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer
Kim, H.; Kim, D.-G.; Ha, S.; Jang, J.-Y.; Vitorino, F. N. d. L.; Gongora, J. M.; Kim, W.; Oh, Y.; Park, G.; Kang, H.; Im, S.-H.; Jung, C. K.; Kim, S.-Y.; Jung, I.; Won, J.-k.; Garcia, B. A.; Kim, S.-j.; Lee, K. E.; Ryu, J.-K.; Lee, C.-H.
10.1101/2025.05.06.652476 — molecular biology — Posted on 2025-05-11
3702 Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma
Phuong, D. J.; Ralston, C. Q.; Ezzat, T. M.; Ashe, C. S.; Armstrong, A. P.; Flesken-Nikitin, A.; Yamulla, R. J.; Nikitin, A. Y.; Schimenti, J. C.
10.1101/2025.03.10.642422 — cancer biology — Posted on 2025-05-11
3704 Genome-wide association study reveals KCNQ3 gene as a risk factor for fear-related behavior in dogs and zebrafish
Kubinyi, E.; Sandor, S.; Tatrai, K.; Varga, Z.; Varga, Z. K.; Topal, J.; Varga, M.; Jonas, D.; Turcsan, B.
10.1101/2025.05.07.652122 — animal behavior and cognition — Posted on 2025-05-11
3707 Lack of Vector Competence in UK Culex pipiens molestus for Oropouche Virus
Pilgrim, J.; Sy, V. S.; Multeau, Q.; Komarasamy, T. V.; Kohl, A.; Blagrove, M. S.; Tanianis-Hughes, J.; Medlock, J.; Sanders, C.; Baylis, M.; Dietrich, I.
10.1101/2025.05.07.652619 — microbiology — Posted on 2025-05-11
3709 Real time evaluation of the liver microcirculation by whole organ machine perfusion within an MRI system
Rai, Z. L.; Holroyd, N. A.; Magbagbeola, M.; Doganay, E.; Doyle, K.; Caselton, L.; Stili, A.; Stoyanov, D.; Walker-Samuel, S.; Davidson, B. R.
10.1101/2025.05.08.652602 — physiology — Posted on 2025-05-11
3710 CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants
Huang, J.; Yang, Z.; Yin, M.; Li, C.; Li, J.; Wang, Y.; Huang, L.; Liang, C.; He, F.; Li, M.; Han, R.; Jiang, Y.
10.1101/2024.12.29.630569 — bioinformatics — Posted on 2025-05-11
3714 Triple-N Dataset: Non-human Primate Neural Responses to Natural Scenes
Li, Y.; Liu, X.; Li, W.; Yang, J.; Gong, B.; Jin, W.; Gong, Z.; Wang, K.; Luo, J.; Zhao, Z.; Bao, P.
10.1101/2025.05.06.652408 — neuroscience — Posted on 2025-05-11
3720 bHLH35 mediates specificity in plant responses to multiple stress conditions
Sinha, R.; Zandalinas, S. I.; Pelaez-Vico, M. A.; Ghani, A.; Khan, M. A.; Induri, S. P.; Bereimipour, A.; Ghandour, T.; Ogden, A.; Huang, S.-S. C.; Azad, R.; Mendoza, D. G.; Joshi, T.; Fritschi, F. B.; Mittler, R.
10.1101/2025.05.07.652729 — plant biology — Posted on 2025-05-11
3721 POLYGALACTURONASES REGULATED BY AUXIN facilitate root cell elongation in Arabidopsis thaliana via pectin remodeling
Kubalova, M.; Kampova, A.; Vosolsobe, S.; Raabe, K.; Simonaviciene, B.; Benitez-Alfonso, Y.; Muller, K.; Medvecka, E.; Fendrych, M.
10.1101/2025.05.07.652666 — plant biology — Posted on 2025-05-11
3722 A Unique LHCE Light-Harvesting protein Family is involved in Photosystem I and II Far-Red Absorption in Euglena gracilis
Miranda-Astudillo, H.; Arshad, R.; Vega de Luna, F.; Aguilar-Gonzalez, Z.; Foret, H.; Feller, T.; Gervasi, A.; Nawrocki, W.; Counson, C.; Morsomme, P.; Degand, H.; Baurain, D.; Kouril, R.; Cardol, P.
10.1101/2025.05.07.652572 — plant biology — Posted on 2025-05-11
3724 3D X-ray microscopy lights up nanoparticles in plants
Kristensen, E. V.; Siracusa, F.; Pinna, A.; Ertem, I.; Szameitat, A.; Villanova, J.; Gao, X.; Schiefler, A.; Tobler, D. J.; Ghoshal, S.; Husted, S.; Mokso, R.
10.1101/2025.05.08.652794 — plant biology — Posted on 2025-05-11
3725 Imputation integrates single-cell and spatial gene expression data to resolve transcriptional networks in barley shoot meristem development
Demesa-Arevalo, E.; Dorpholz, H.; Vardanega, I.; Maika, J. E.; Pineda-Valentino, I.; Eggels, S.; Lautwein, T.; Kohrer, K.; Schnurbusch, T.; von Korff, M.; Usadel, B.; Simon, R.
10.1101/2025.05.09.653223 — plant biology — Posted on 2025-05-11
3726 The bivalent epigenetic regulator ULTRAPETALA1 promotes the Arabidopsis floral transition via recruitment of Polycomb histone methyltransferases for H3K27me3 deposition at the FLC locus
Xing, Q.; Shemyakina, E.; Tian, J.; Strotmann, V. I.; Anwar, A.; Li, X.; Xiong, Y.; Yang, T.; Zheng, Y.; Pu, L.; Stahl, Y.; Mueller-Xing, R.; Fletcher, J. C.
10.1101/2025.05.06.652514 — plant biology — Posted on 2025-05-11
3728 Transcriptomic and physiological responses of soybean plants subjected to a combination of water deficit and heat stress under field conditions
Sinha, R.; Pelaez-Vico, M. A.; Dhakal, S.; Ghani, A.; Myers, R.; Verma, M.; Shostak, B.; Ogden, A.; Krueger, C. B.; Costa Netto, J. R.; Zandalinas, S. I.; Joshi, T.; Fritschi, F. B.; Mittler, R.
10.1101/2025.05.07.652738 — plant biology — Posted on 2025-05-11
3731 Structural insights into late-stage photosystem II assembly by Psb32
Bohn, S.; Lo, Y. K.; Lambertz, J.; Meier-Credo, J.; Fuertges, T.; Liauw, P.; Gasper-Schoenenbruecher, R.; Wiens, D.; Langer, J.; Hochberg, G.; Hofmann, E.; Rudack, T.; Nowaczyk, M. M.; Schuller, J.
10.1101/2025.05.08.652833 — plant biology — Posted on 2025-05-11
3732 Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
Saini, P.; Mirji, G.; Bhat, S. A.; Muthumani, K.; Cassel, J.; Tang, H.-Y.; Tateno, H.; Zhang, R.; Shinde, R.; Abdel-Mohsen, M.
10.1101/2025.05.06.652455 — immunology — Posted on 2025-05-11
3733 A Foraging-Theory Based Model Captures The Full Spectrum of Human Behavioral Diversity in a Classic RL Task
Harrell, D.; Zid, M.; Laurie, V.-J.; Chen, C.; Grissom, N.; Darrow, D. P.; Ebitz, B. R.; Herman, A. B.
10.1101/2025.05.06.652482 — neuroscience — Posted on 2025-05-11
3734 Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing
Chen, H.; Cretu, C.; Trebilcock, A.; Evdokimova, N.; Babai, N.; Feldmann, L.; Leidner, F.; Benseler, F.; Mutschall, S.; Esch, K.; Kibedi, C. Z.; Pena, V.; Pape, C.; Grubmüller, H.; Strenzke, N.; Brose, N.; Wichmann, C.; Preobraschenski, J.; Moser, T.
10.1101/2025.05.10.653085 — neuroscience — Posted on 2025-05-11
3737 Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology
Haghani, V.; Ali, S. M.; Cannizzaro, N.; Patil, M. M.; Sullivan, P. D. M.; Rehman, A.; Green, R.; Ben-Shalom, R.; LaSalle, J.; Zarbalis, K.
10.1101/2025.05.07.652681 — neuroscience — Posted on 2025-05-11
3742 An evolutionary approach to predict the orientation of CRISPR arrays
Fehrenbach, A.; Mitrofanov, A.; Alkhnbashi, O.; Backofen, R.; Baumdicker, F.
10.1101/2025.05.09.653049 — bioinformatics — Posted on 2025-05-11
3743 Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Capeling, M.; Chen, B.; Aliar, K.; Penna, E.; Lopez, V. I.; Foo, C.; Rost, S.; Holokai, L.; Tong, X.; Philipps, D.; Sweet, C.; Li, J.; Chatterjee, S.; Skippington, E.; Modrusan, Z.; McGinnis, L. M.; Wei, R.; Keir, M.; Rozenblatt-Rosen, O.; Chen, M. B.
10.1101/2025.05.06.652311 — bioengineering — Posted on 2025-05-11
3744 An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis
O'Neill, A. G.; McCartney, M. E.; Wheeler, G. M.; Patel, J. H.; Sanchez-Ramirez, G.; Kollman, J. M.; Wills, A. E.
10.1101/2025.05.09.652712 — biochemistry — Posted on 2025-05-11
3748 Ultrasmall chemogenetic tags with group-transfer ligands
Vedagopuram, S.; Sindi, S. H.; Chaudhary, S. K.; Pergu, R.; Singh, P.; Karaj, E.; Fung, J. E.; Deb, A.; DeCarlo, S. J.; Mercer, J. A. M.; Yamada, K.; Rodriguez, D.; Liu, D. R.; Choudhary, A.
10.1101/2025.05.10.653252 — synthetic biology — Posted on 2025-05-10
3749 GWAs reveals SUBER GENE1-mediated suberization via Type One Phosphatases
Han, J.-P.; Lefebvre-Legendre, L.; Capitao, M. B.; Gully, K.; Shukla, V.; Wu, Y.; Nawrath, C.; Barberon, M.
10.1101/2025.05.06.652434 — plant biology — Posted on 2025-05-10
3750 Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces
Zikai, G.; Lijuan, M.; Hang, F.; Chenguang, Y.; Dongfei, M.; Hongtao, Z.; Yumei, W.; Dapeng, S.; Shuxin, H.; Chunhua, X.; Wei, D.; Jianbing, M.; Ying, L.; Ming, L.
10.1101/2025.05.06.652550 — biophysics — Posted on 2025-05-10
3753 RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation
Shimanski, B.; Marin, J. F.; Warminski, M.; McKeon, R. M.; Kowalska, J.; Jemielity, J.; Hadden-Perilla, J. A.; Mugridge, J. S.
10.1101/2025.05.09.653100 — biochemistry — Posted on 2025-05-10
3755 Human Messenger RNA Harbors Widespread Noncoding Splice Isoforms
Shi, Q.; Li, H.; Song, J.; Wu, H.; Zeng, Y.; Jiang, J.; Li, S.; Chen, Z.; He, X.
10.1101/2025.05.06.652571 — genomics — Posted on 2025-05-10
3756 Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses
Dien, V.; Thompson, C.; Rammel, T.; Roquero, J.; Krivit, M.; Yeo, G.; Honigfort, D.; Bhadha, P.; Brown-Greeves, C.; Dawood, M.; Elango, K.; Kwon, H. J.; Lopez, T.; Lo, A.; Manjunath, M.; Ren, P.; Song, B.; Sundkamp, M.; Tippana, R.; Van IJcken, W.; Wong, J.; Yao, J.; Zhou, D.; Arslan, S.; Kellinger, M.; Kia, A.; Kruglyak, S.; Previte, M.; He, M.
10.1101/2025.05.06.652479 — genomics — Posted on 2025-05-10
3757 ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
Simoes-Sousa, S.; Amin, N.; Lane, K. A.; Harrod, A.; Pedersen, M.; Pardo, M.; Rasetti-Escargueil, C.; Kozik, Z.; Begg, K. A. G.; Ribeiro, A.; Banerjee, S.; Stucki, M.; Harrington, K. J.; Chaudhary, J. S.; Downs, J. A.
10.1101/2025.05.10.653238 — molecular biology — Posted on 2025-05-10
3759 Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose
Kloet, M.; Chatrin, C.; Mukhopadhyay, R.; van Tol, B.; Smith, R.; Rotman, S.; Tjokrodirijo, R. T. N.; Zhu, K.; Gorelik, A.; van Veelen, P. A.; Ahel, D.; Ahel, I.; van der Heden van Noort, G. J.
10.1101/2025.05.08.652854 — molecular biology — Posted on 2025-05-10
3760 Host microbiome determines host specificity of the human whipworm, Trichuris trichiura
Stark, K. A.; Mkandawire, T. T.; Tolley, C.; Thompson, S.; Fortune-Grant, R.; Brandt, C.; Clare, S.; Lawley, T. D.; Cantacessi, C.; Almeida, A.; Grencis, R. K.; Nejsum, P.; Berriman, M.; Duque-Correa, M. A. A.
10.1101/2025.05.09.653168 — microbiology — Posted on 2025-05-10
3763 Reversion of a RND transporter pseudogene uncovers latent stress resistance in Brucella ovis
Kim, T.; Hong, B.; O'halloran, T.; Lisabeth, E.; Neubig, R.; Fiebig, A.; Crosson, S.
10.1101/2025.05.10.653276 — microbiology — Posted on 2025-05-10
3767 Assessment of nucleic acid structure prediction in CASP16
Kretsch, R. C.; Hummer, A. M.; He, S.; Yuan, R.; Zhang, J.; Karagianes, T.; Cong, Q.; Kryshtafovych, A.; Das, R.
10.1101/2025.05.06.652459 — biophysics — Posted on 2025-05-10
3769 mtgRNA-db: An annotated database of multi-target CRISPR-Cas9 guide-RNAs in the human genome
Modrek, A. S.; Huynh, K.; Do, C.; Karp, J.; Deng, Y.; Zhang, Z.; Ezhilarasan, R.; Valor, B.; Cova, G.; Skok, J. A.; Sulman, E. P.
10.1101/2025.05.07.652656 — bioinformatics — Posted on 2025-05-10
3773 Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity
Barbieri, E. M.; Linsenmeier, M.; Whiteman, K. R.; Cheng, Y.; Braganza, S.; Copley, K. E.; Miranda-Castrodad, P.; Lewis, B.; Villafane, K.; Amado, D. A.; Davidson, B. L.; Shorter, J.
10.1101/2025.05.10.653282 — biochemistry — Posted on 2025-05-10
3775 eLaRodON: identification of large genomic rearrangements in Oxford Nanopore sequencing data
Mikheeva, R.; Koryukov, M.; Leonov, P.; Mukhametdinova, V.; Borobova, V.; Laktionov, P.; Tarkhov, A.; Filipenko, M.; Kechin, A.
10.1101/2025.05.07.652628 — genomics — Posted on 2025-05-10
3777 DSB repair kinetics impair CRISPR-Cas9 editing in human embryos
Egli, D.; Marin, D.; Treff, N.; Jerabek, S.; Sung, J.; Xu, J.; Talukdar, J.
10.1101/2025.05.07.652614 — developmental biology — Posted on 2025-05-10
3778 EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer
Lee, C.-H.; Kim, H.; Kim, D.-G.; Ha, S.; Jang, J.-Y.; Vitorino, F. N. d. L.; Gongora, J. M.; Kim, W.; Oh, Y.; Park, G.; Kang, H.; Im, S.-H.; Jung, C. K.; Kim, S.-Y.; Jung, I.; Won, J.-k.; Garcia, B. A.; Kim, S.; Lee, K. E.; Ryu, J.-K.
10.1101/2025.05.06.652476 — molecular biology — Posted on 2025-05-10
3779 Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts
Harrison, M.-C.; Rinker, D. C.; LaBella, A. L.; Opulente, D. A.; Wolters, J.; Zhou, X.; Shen, X.-X.; Groenewald, M.; Hittinger, C. T.; Rokas, A.
10.1101/2025.05.09.653161 — microbiology — Posted on 2025-05-10
3781 Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome
Corona-Cervantes, K.; Urrutia-Baca, V. H.; Gamez-Valdez, J. S.; Jimenez-Lopez, B.; Rodriguez-Gutierrez, N. A.; Chavez-Caraza, K.; Espiricueta-Candelaria, F.; Salas-Villalobos, U. A.; Ramos-Parra, P.; Gutierrez-Uribe, J. A.; Brunck, M.; Chuck-Hernandez, C.; Licona-Cassani, C.
10.1101/2025.05.09.653164 — microbiology — Posted on 2025-05-10
3782 Miniature bioreactor arrays for modeling functional and structural dysbiosis in inflammatory bowel disease
Newman, K. L.; Standke, A.; James, G.; Vendrov, K. C.; Inohara, N.; Bergin, I. L.; Higgins, P.; Rao, K.; Young, V. B.; Kamada, N.
10.1101/2025.05.09.653173 — microbiology — Posted on 2025-05-10
3783 Discovering Broader Host Ranges and an IS-bound Prophage Class Through Long-Read Metagenomics
Wirbel, J.; Hickey, A. S.; Chang, D.; Enright, N. J.; Dvorak, M.; Chanin, R. B.; Schmidtke, D. T.; Bhatt, A. S.
10.1101/2025.05.09.652943 — microbiology — Posted on 2025-05-10
3787 Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes
Zheng, L.; Yan, Y.; Zhou, B.; Lim, J.; Shi, D.; An, B.; Ko, B.; Klyder, E.; Pitchiaya, S.; Cai, D. J.; Boyden, E. S.; Wei, D.; Lio, P.; Linghu, C.
10.1101/2025.05.10.653182 — synthetic biology — Posted on 2025-05-10
3790 Dietary Resilience of Termite Gut Microbiota and Enzymatic Function Reflects Feeding Strategy
Menezes, L. R. d.; Franco Cairo, J. P. L.; Costa-Leonardo, A. M.; Clerici, M. T. P. S.; Barreto, I. d. C.; dos Santos, B. S. F.; Arab, A.
10.1101/2025.05.07.651711 — ecology — Posted on 2025-05-10
3792 MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies
Silva, M. C.; Lindmeier, H.; Pigini, P.; Laughlin, J.; Yu, Y.; Morrill, C.; Arnold, M. A.; Barraza, S. J.; Saadipour, K.; Dieterich, M.; Minnella, A.; Datta, K.; Zhang, N.; Narasimhan, J.; Trotta, C. R.; Woll, M. G.; Welch, E. M.; Benzow, K.; Karanjeet, K.; Lotz, S.; Bertucci, T.; Temple, S.; Haggarty, S. J.; Koob, M.; Trimmer, J.; Weetall, M.; Morini, E.
10.1101/2025.05.06.652428 — neuroscience — Posted on 2025-05-10
3793 Disruption of grin2A, an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish
Abramova, V.; Tomovic, E.; Kysilov, B.; Korinek, M.; Dobrovolski, M.; Hrcka Krausova, B.; Fili, K.; S. Abdel Rahman, F. E.; Bozikova, P.; Cerny, J.; Smejkalova, T.; Balik, A.; Vyklicky, L.
10.1101/2025.05.09.651809 — neuroscience — Posted on 2025-05-10
3798 Early-life paternal relationships predict adult female survival in wild baboons
Jansen, D. A. W. A. M.; Warutere, J. K.; Tung, J.; Alberts, S. C.; Archie, E.
10.1101/2025.01.22.634342 — evolutionary biology — Posted on 2025-05-10
3799 Potential yield and food provisioning gains from rebuilding the worlds coral reef fish stocks
Zamborain-Mason, J.; Cinner, J. E.; MacNeil, M. A.; Beger, M.; Booth, D.; Ferse, S. C. A.; Golden, C. D.; Graham, N. A.; Hoey, A. S.; Moulliot, D.; Connolly, S. R.
10.1101/2025.05.06.652379 — ecology — Posted on 2025-05-10
3802 NOD2 modulates MDA5 signaling to promote coxsackievirus B3 replication
Kuss-Duerkop, S. K.; Atencio, L. C.; Nail, E. A.; Sparks, I. L.; Huynh, T. N.; Russo, B. C.; Keestra-Gounder, A. M.
10.1101/2025.05.06.652463 — immunology — Posted on 2025-05-10
3803 Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity derived biomarkers
Mehra, C.; Beyh, A.; Laiou, P.; Garces, P.; Jones, E.; Mason, L.; Buitelaar, J.; Johnson, M.; Murphy, D.; Loth, E.; Dell' Acqua, F.; Ewen, J.; Richardson, M.; O'Muircheartaigh, J.
10.1101/2025.01.04.631256 — neuroscience — Posted on 2025-05-10
3804 Performance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput
Sinn, L. R.; Wang, Z.; Alvarez, C.; Chelur, A.; Batruch, I.; Pribil, P.; Ludwig, D.; Tate, S.; Castro-Perez, J.; Messner, C.; Demichev, V.; Ralser, M.
10.1101/2025.05.06.652368 — systems biology — Posted on 2025-05-10
3808 Expanding the definition of MHC Class I peptide binding promiscuity to support vaccine discovery across cancers with CARMEN
Waleron, M. M.; Kallor, A. A.; Palkowski, A.; Daghir-Wojtkowiak, E.; Borole, P.; Kocikowski, M.; Polom, K.; Marino, F.; Monterde, B.; Mastromattei, M.; Venditti, D.; Stares, M.; The KATY Consortium, ; Singh, A.; Hupp, T.; Battail, C.; Laird, A.; Pesquita, C.; Zapata, L.; Symeonides, S. N.; Rajan, A.; Zanzotto, F. M.; Alfaro, J. A.
10.1101/2025.05.08.651510 — bioinformatics — Posted on 2025-05-10
3809 CLONEID: A Framework for Monitoring and Steering Subclonal Dynamics
Veith, T.; Beck, R. J.; Tagal, V.; Li, T.; Alahmari, S.; Cole, J.; Hannaby, D.; Yu, X.; Maksin, K.; Schultz, A.; Lee, H.; El Naqa, I.; Eschrich, S. A.; Lupo, J.; Ji, H.; Diaz, A.; Andor, N.
10.1101/2025.05.07.652202 — bioinformatics — Posted on 2025-05-10
3812 In vivo tracking of CAR-T cells in tumors via nanobubble-based contrastenhanced ultrasound
Durig, D.; Franklin, J.; Perera, R.; Jackson, Z.; Vasanna, H.; Kolios, M.; Wald, D.; Exner, A. A.
10.1101/2025.05.06.651695 — bioengineering — Posted on 2025-05-10
3813 Uniaxial tensile tests and Digital Image Correlation analysis for the mechanical characterization of human Fascia Lata under different decellularization treatments
Demontis, F.; Loi, G.; Mazzotti, E.; Rodriguez Reinoso, M.; Vecchio, F.; Faini, A. C.; Leone, A.; Camusso, E.; Genzano Besso, F.; Surace, C.; Lacidogna, G.; Scaramozzino, D.
10.1101/2025.05.10.651796 — bioengineering — Posted on 2025-05-10
3814 Pre-Analytical Drivers of Bias in Bead-Enriched Plasma Proteomics
Korff, K.; Mueller-Reif, J. B.; Fichtl, D.; Albrecht, V.; Schebesta, A.-S.; Itang, E. C. M.; Virreiera Winter, S.; Holdt, L. M.; Teupser, D.; Mann, M.; Geyer, P. E.
10.1101/2025.05.07.652495 — biochemistry — Posted on 2025-05-10
3816 Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang, J.; Ubas, A. A.; de Borja, R.; Svensson, V.; Thomas, N.; Thakar, N.; Winters, A.; Khan, U.; Jones, M. G.; Thompson, J. D.; Tran, V.; Pangallo, J.; Papalexi, E.; Sapre, A.; Nguyen, H.; Sanderson, O.; Nigos, M.; Kaplan, O.; Schroeder, S.; Hariadi, B.; Marrujo, S.; Salvino, C. C. A.; Gallareta Olivares, G.; Koehler, R.; Geiss, G.; Rosenberg, A.; Roco, C.; Merico, D.; Alidoust, N.; Goodarzi, H.; Yu, J.
10.1101/2025.02.20.639398 — genomics — Posted on 2025-05-10
3820 Formation of chromosomal rearrangements in Saccharomyces cerevisiae diploids through regionally-biased non-allelic homologous recombination
Merriman, S. A.; Chapman, M. J.; Stewart, J. A.; Schmelzer, C. D.; Sharif, R. S.; Hemmerlein, M. J.; Puccia, C. M.; de Mattos, G. M.; Wienke, M. A.; Cornelio, D. A.; Dilsaver, M.; Watson, R. A.; Argueso, J. L.
10.1101/2025.05.08.650247 — genetics — Posted on 2025-05-10
3821 When less is not more: Limits to the evolution of metabolic dependence in spatially structured microbial communities
Ramesh, D.; Fara, E.; Oschmann, F.; Ugolini, G. S.; Stocker, R.; van Vliet, S.; Ackermann, M.; Schubert, O. T.
10.1101/2025.05.09.651753 — evolutionary biology — Posted on 2025-05-10
3822 The effectiveness of selection in a species affects the direction of amino acid frequency evolution
McShea, H.; Wheeler, A. L.; Goodman, P.; Weibel, C. A.; Wehbi, S.; James, J. E.; Huttley, G. A.; Masel, J.
10.1101/2023.02.01.526552 — evolutionary biology — Posted on 2025-05-10
3823 Selective RNA sequestration in biomolecular condensates directs cell fate transitions
Pessina, P.; Nevo, M.; Shi, J.; Kodali, S.; Casas, E.; Cui, Y.; Richards, A. L.; Park, E. J.; Chen, X.; Levin-Ferreyra, F.; Stevenson, E.; Krogan, N. J.; Swaney, D. L.; Ying, Q.; Chen, Q.; Brumbaugh, J.; Di Stefano, B.
10.1101/2025.05.08.652299 — cell biology — Posted on 2025-05-10
3825 Specificity and mechanism of the double-stranded RNA-specific J2 monoclonal antibody
Bou-nader, C.; Juma, K. M.; Bothra, A.; Brasington, A. J.; Ghirlando, R.; Suzuki, M.; Garboczi, D. N.; Leppla, S. H.; Zhang, J.
10.1101/2025.05.09.649859 — molecular biology — Posted on 2025-05-10
3826 Early adjunct anti-PD-L1 immunotherapy improves outcomes and restores infection-induced immune paralysis in mice with invasive pulmonary mucormycosis
Wurster, S.; Pantaleon Garcia, J.; Wang, Y.; Albert, N. D.; Bharadwaj, U.; Matula, L.; Lewis, R. E.; Evans, S. E.; Kontoyiannis, D. P.
10.1101/2025.05.06.652431 — immunology — Posted on 2025-05-10
3827 Expectation modulates the hedonic experiences of and midbrain responses to sweet flavour
Mainetto, E.; Westwater, M. L.; Ziauddeen, H.; Diederen, K. M.; Fletcher, P. C.
10.1101/2025.05.09.651338 — neuroscience — Posted on 2025-05-10
3830 Region-specific Brain Targets Drive Circuit Formation and Maturation of Human Retinal Ganglion Cells
Huang, K.-C.; Jeng, H.-Y.; Abdulwahab, Q.; Cuevas, V.; Shihabeddin, E.; Young, C.; Hernandez, M.; Tran, N.; Samuel, M. A.; Meyer, J. S.
10.1101/2025.05.10.651091 — neuroscience — Posted on 2025-05-10
3836 Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis
Deepagan, V. G.; Ma, X.; Bazregari, F.; Pang, J.; Schaefer, J.; Hildebrand, J. M.; Dempsey, R. K.; Doerflinger, M.; Baldwin, C. A.; Schmidt, F. I.; Murphy, J. M.; Salvamoser, R.; Vince, J. E.
10.1101/2025.05.06.652432 — bioengineering — Posted on 2025-05-10
3838 A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptide
Tejero-Ojeda, M. M.; Vives, A. B.; Wojciechowski, M.; Huy, P. D. Q.; Chwastyk, M.; Vallejo, M.; Novials, A.; Carrion-Vazquez, M.
10.1101/2025.05.06.652241 — biochemistry — Posted on 2025-05-10
3839 Ist2 promotes lipid transfer by Osh6 via its membrane tethering and lipid scramblase activities
Fabbre, A.; Syska, C.; Gobbi Sebinelli, H.; Cardinal, A.; Magdeleine, M.; Al-Qatabi, N.; D Ambrosio, J. M.; Montigny, C.; Lenoir, G.; Copic, A.; DRIN, G.
10.1101/2025.05.06.652365 — biochemistry — Posted on 2025-05-10
3841 Specific Pathogen Free Ten Gene-Edited Pig Donor for Xenotransplantation
Xu, K.; Zhao, H.; Jia, B.; Wang, J.; Siddig, N. A. M. A.; Jamal, M. A.; Mao, A.; Liu, K.; Cheng, W.; Yang, C.; Wei, T.; Zhu, F.; Huo, X.; Jiao, D.; Guo, J.; Zhao, H.; Cheng, W.; Zhang, Y.; Zhang, X.; Jiang, L.; Zhang, Z.; Zhang, W.; Liang, T.; Zhao, H.-Y.; Sun, B.-C.; Wei, H.-J.
10.1101/2025.05.06.652168 — immunology — Posted on 2025-05-10
3846 Concerted genome expansion of heritable symbionts in an insect host
Hornett, E. A.; Hayashi, M.; Nagamine, K.; Paterson, S.; Kageyama, D.; Hurst, G. D. D.
10.1101/2025.05.06.652349 — genomics — Posted on 2025-05-10
3847 Ancient introgression explains mitochondrial genome capture and mitonuclear discordance among South American collared Tropidurus lizards
Salles, M. M. A.; Carvalho, A. L. G.; Leache, A. D.; Martinez, N.; Bauer, F.; Motte, M.; Espinola, V.; Rodrigues, M. T.; Piantoni, C.; Pie, M. R.; Olivotto, A.; Colli, G. R.; Choueri, E. L.; Werneck, F. P.; Domingos, F. M. C. B.
10.1101/2025.04.25.650633 — genomics — Posted on 2025-05-10
3848 An essential role for the Hv1 voltage-gated proton channel in Pseudomonas aeruginosa corneal infection
Rodriguez, P.; Abbondante, S.; Marshall, M. M.; Abdelmeseh, J.; Tombola, F.; Pearlman, E.
10.1101/2024.07.15.603631 — microbiology — Posted on 2025-05-10
3849 Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life development
Lemmik, H.; Kim, E.; MacNicol, E.; Maselli, D.; Bernanos, M.; Li, Z.; Abdullahi, D.; Walters, E.; Serrano Navacerrada, M. E.; Zhou, W.; Ivetic, A.; Cash, D.; Westacott, L.
10.1101/2025.04.24.650541 — neuroscience — Posted on 2025-05-10
3850 Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complex
Stojaspal, M.; Brom, T.; Janovic, T.; Necasova, I.; Veverka, P.; Verma, N.; Uhrik, L.; Hernychova, L.; Hofr, C.
10.1101/2023.05.25.542057 — biochemistry — Posted on 2025-05-10
3851 Targeted Protein Degradation in Escherichia coli - depletion of the essential GroEL using CLIPPERs
Izert-Nowakowska, M. A.; Klimecka, M. M.; Antosiewicz, A.; Wroblewski, K.; Kowalski, J. J.; Bandyra, K. J.; Goral, T. K.; Kmiecik, S.; Serwa, R. A.; Gorna, M. W.
10.1101/2024.02.29.582761 — molecular biology — Posted on 2025-05-10
3852 Valence-dependent sensory-rhythmic stimulation entrains cortico-subcortical networks and enhances attention and memory
Hoyer, R. S.; Bernier, M.-F.; Martineau, L.; Lessard Bonaventure, P.; Labelle, C.; Borderie, A.; Blanchette, I.; Blumenthal, A.; Laureys, S.; Albouy, P.
10.1101/2025.01.03.631218 — neuroscience — Posted on 2025-05-10
3853 Mitfa-Independent Melanocyte Progenitors are Highly Susceptible to GNAQ-induced Uveal Melanoma in Adult Zebrafish
Yevdash, J. I.; Moore, R.; Li, Z.; Campbell-Hanson, K. R.; Robinson, D.; Gutelius, D.; Moore, S. P. G.; Friend, D.; O'Toole, I.; Cornell, R. A.; Lang, D.; Weigel, R. J.; Kenny, C.
10.1101/2025.05.05.652300 — cancer biology — Posted on 2025-05-10
3857 Biocultural vulnerability of traditional crops in the Indian Trans Himalaya
Jaggi, H.; Anand, A.; Solari, K. A.; Echeverri, A.; Tobge, R.; Tsewang, T.; Suryawanshi, K.; Tuljapurkar, S. D.
10.1101/2024.10.22.619747 — plant biology — Posted on 2025-05-10
3858 A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity
Djajawi, T. M.; Huber, A.; Mendoza Rivera, S.; Srivaths, A.; Salehi, M.; Gunay, G.; Gerak, C.; Neil, L.; Ozaydin, O.; Voulgaris, O.; Al Halawani, A.; Gannon, D.; Khoshdoozmasouleh, N.; Jenkins, L. J.; Chan, K. F.; Behren, A.; Ernst, M.; Mielke, L. A.; Lelliott, E. J.; Dong, H.; Feltham, R.; Sutton, V. R.; Trapani, J. A.; Mariadason, J. M.; Pal, B.; Martin, S. J.; Vervoort, S. J.; Kearney, C. J.
10.1101/2025.05.09.652721 — cancer biology — Posted on 2025-05-10
3859 IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas
Arribas, A. J.; Guidetti, F.; Cannas, E.; Cascione, L.; Napoli, S.; Sartori, G.; Fuzio, F.; Pesenti, E.; Tarantelli, C.; Spriano, F.; Zucchetto, A.; Rossi, F. M.; Bruscaggin, A.; Rinaldi, A.; Castro de Moura, M.; Jovic, S.; Raimondi, A.; Pittau, R. B.; Terzi di Bergamo, L.; Ye, X.; Stathis, A.; Ben-David, Y.; Pan-Hammarstrom, Q.; Simonetta, F.; Stussi, G.; Zucca, E.; Gattei, V.; Brown, J. R.; Esteller, M.; Rossi, D.; Bertoni, F.
10.1101/2025.05.07.652612 — cancer biology — Posted on 2025-05-10
3861 SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma.
Chakraborty, K.; Burman, R.; Satheesh, S.; Kieffer, M.; Karuhatty, C.; Yuan, Z.-F.; Tan, H.; Lkhagva, A.; High, A. A.; Wang, X.; Refaat, A.; Zhang, W.; Wang, Y.; Fan, Y.; Babu, M. M.; Shelat, A.; Stewart, E.; Dyer, M. A.; Bagga, P.
10.1101/2025.05.09.652501 — cancer biology — Posted on 2025-05-10
3865 p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancer
Rajan, P.; Zollo, R.; Guo, Y.; Alruwaili, M.; Zonneville, J.; Lieberman, M.; Morreale, B.; James, C.; Long, M.; Olejniczak, S.; Barbi, J.; Abrams, S.; Bakin, A. V.
10.1101/2025.05.08.652949 — cancer biology — Posted on 2025-05-10
3866 Complementary modes of resistance to EGFR TKI in lung adenocarcinoma through MAPK activation and cellular plasticity
Zatzman, M.; Quintanal-Villalonga, A.; Salehi, S.; Ceglia, N.; Lee, J. J.-K.; Pupo, A. N.; Falcon, C. J.; Rusk, N.; Masilionis, I.; Chaudhary, O.; Manoj, P.; Chaligne, R.; McPherson, A.; Rudin, C. M.; Shah, S. P.; Yu, H. A.
10.1101/2025.05.07.652714 — cancer biology — Posted on 2025-05-10
3868 FASN Inactivation-induced Progranulin (GRN) Expression Promotes Lysosome-dependent Cell Death to Suppress Leukemogenesis
Su, M.; Lv, Z.; Lu, Y.; Xie, X.; Zou, A.; Liu, H.; Ouyang, J.; Li, Q.; Ma, X.; Yang, Y.; Liu, K.; He, Y.; Xu, S.; Li, J.; Chen, L.; Lu, X.; Yang, J.; Liu, L.; Wu, C.; Zhang, L.; Sheng, Y.; Huang, Y.; Mei, Y.
10.1101/2025.05.06.652401 — cancer biology — Posted on 2025-05-10
3871 Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis
Beernaert, B.; Jady-Clark, R. L.; Shah, P.; Ramon-Gil, E.; Lawson, N. M.; Brodtman, Z. D.; Tagore, S.; Stihler, F.; Carter, A. S.; Clarke, S.; Liu, T.; Zhu, W.; Erdal, E.; Easton, A.; Campo, L.; Browne, M.; Ash, S.; Waddell, N.; Crosby, T.; Lord, S. R.; Mann, D. A.; Melero, I.; de Andrea, C. E.; Tijhuis, A. E.; Foijer, F.; Hammond, E. M.; Akdemir, K. C.; Leslie, J.; Izar, B.; Parkes, E. E.
10.1101/2025.05.06.652454 — cancer biology — Posted on 2025-05-10
3872 Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation
Mestvedt, I. B.; Menu, E.; Misund, K.; Slordahl, T. S.; Rasheed, K.; Wolowczyk, C. I.; Hella, H.; Ryan, L.; Standal, T.; Espevik, T.; Yurchenko, M.
10.1101/2025.05.07.652607 — cancer biology — Posted on 2025-05-10
3873 Discovery and characterization of FX-909, a covalent inverse agonist of PPARG rationally designed to impose a powerful repressive bias in PPARG for the treatment of PPARG/RXRA-activated muscle-invasive urothelial cancers
Stuckey, J. I.; Mertz, J. A.; Wilson, J. E.; Williamson, K. E.; Li, Y.; Kuljanin, M.; DeLaBarre, B.; Chenail, G.; Nguyen, P. A.; Bailey, C. M.; Motley, W. M.; Audia, J. E.; Sims, R. J.
10.1101/2025.05.08.652848 — cancer biology — Posted on 2025-05-10
3877 GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases
Sriramareddy, S.; Siddarajappa, N.; Park, J. S.; Nguyen, T.; Kuznetsoff, J. N.; Kurtenbach, S.; Dollar, J. J.; Adams, D.; Licht, J.; Correa, Z.; Chen, A.; Harbour, J. W.; Smalley, K.
10.1101/2025.05.07.652654 — cancer biology — Posted on 2025-05-10
3878 Three-dimensional topological defects and quasi-long-range order in biological liquid crystals
Argento, A. E.; Varela, M. L.; Singh, G.; Visnuk, D. P.; Jacobovitz, B.; Rutherford, M. E.; Edwards, M. B.; Chaboche, Q.; Orringer, D. A.; Heth, J. A.; Castro, M. G.; Beller, D. A.; Blanch-Mercader, C.; Lowenstein, P.
10.1101/2025.04.14.648711 — biophysics — Posted on 2025-05-10
3884 Functional Genomic Screens Reveal RBBP4 as a Key Regulator of Cell Cycle Progression in TMZ-Resistant Glioblastoma
Kala, E. Y.; Senbabaoglu Aksu, F.; Ercan, E.; Ozbiyik, A.; Cingoz, A.; Yedier-Bayram, O.; Aksu, A. C.; Cavga, A. D.; Yilmaz, E.; Kok, I.; Dur Karasayar, A. H.; Kulac, I.; Syed, H.; Philpott, M.; Cribbs, A. P.; Bagci-Onder, T.
10.1101/2025.05.09.653010 — cancer biology — Posted on 2025-05-10
3885 The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer
Gupta, P.; Murad, R.; Ling, L.; Zhang, Y.; Duong-Polk, K.; Maganti, S.; Galapate, C.; Commisso, C.
10.1101/2025.05.08.652966 — cancer biology — Posted on 2025-05-10
3886 The STAMP inhibitor asciminib is a new treatment option for ABL-rearranged ALL revealing a novel role for the 5' fusion partner in determining drug response
Eadie, L. N.; McDougal, D. P.; Lagonik, E.; Schutz, C. E.; Conlin, T. S.; Page, E. C.; Rehn, J.; Bruning, J. B.; Moore, A. S.; Yeung, D. T.; Hughes, T. P.; White, D. L.
10.1101/2025.05.06.652078 — cancer biology — Posted on 2025-05-10
3887 EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism
HASHEMINASABGORJI, E.; Chen, H.-M.; Gatesman, T.; Younes, S. T.; Nobles, G.; Jaryani, F.; Mao, H.; Yu, K.; Deneen, B.; Yong, V. W.; Taylor, M.; Agnihotri, S.; Gallo, M.
10.1101/2025.05.08.652913 — cancer biology — Posted on 2025-05-10
3889 High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular Subtypes
Kisakol, B.; Sturrock, A.; Cho, S.; Azimi, M.; Lindner, A.; Salvucci, M.; McDonough, E.; Fay, J.; O'Grady, T.; McCawley, N.; Burke, J. P.; McNamara, D.; Graf, J.; McDade, S.; Longley, D. B.; Ginty, F.; Prehn, J. H.
10.1101/2025.05.07.652478 — cancer biology — Posted on 2025-05-10
3890 Lymphocyte damage in four differently treated prostate radiotherapy cohort
Kocsis, Z. S.; Agoston, P.; Farkas, G.; Szekely, G.; Sandor, G. O.; Kliton, J.; Gesztesi, L.; Major, T.; Pesznyak, C.; Herein, A.; Stelczer, G.; Mihaly, D.; Frohlich, G.; Takacsi-Nagy, Z.; Polgar, C.; Juranyi, Z.
10.1101/2025.05.07.652586 — cancer biology — Posted on 2025-05-10
3891 Disruption of Microhomology-mediated End-joining in Ewing Sarcoma
Asada, S.; Zhu, G.; Abeykoon, J. P.; Tanaka, Y.; Nguyen, H.; Hirohashi, Y.; Iyer, D. R.; Ashton, N. W.; Mukkavalli, S.; Jiang, L.; Busso, M. D.; Thangaiah, J. J.; Robinson, S. I.; Parmar, K.; Van Allen, E.; Gillani, R.; Shapiro, G. I.; D'Andrea, A. D.
10.1101/2025.05.06.651696 — cancer biology — Posted on 2025-05-10
3892 Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy
Sreekumar, A.; Blankemeyer, E.; Sterner, C. J.; Pan, T.-C.; Pant, D. K.; Acolatse, S.; Turkistani, H.; Belka, G. K.; Carlin, S. D.; Assenmacher, C.-A.; Sellmyer, M. A.; Mankoff, D. A.; Chodosh, L. A.
10.1101/2025.05.07.652632 — cancer biology — Posted on 2025-05-10
3896 Personalized Gut-Liver Microphysiological System Maps Donor-Specific Tissue Resident Immunity and Reveals a Conserved Metabolic Crosstalk
Uslu, M.; Ran, R.; Siddiqui, M. F.; Liang, J.; Raechal, L.; Dogsa, M.; Perrot, C.; Lieberman, L. A.; Brubaker, D. K.; Trapecar, M.
10.1101/2025.05.05.652244 — bioengineering — Posted on 2025-05-10
3897 Impact of Tissue Sample Preparation Methods on Myelin-Sensitive Quantitative MR Imaging
Murguia, A.; Swanson, S. D.; Scheven, U.; Jacobson, A.; Nielsen, J.-F.; Fessler, J. A.; Seraji-Bozorgzad, N.
10.1101/2025.05.05.652075 — bioengineering — Posted on 2025-05-10
3899 Inconsistent relationships detected between seed size, shape, and persistence for different plant functional groups in the Pannonian flora
Törö-Szijgyarto, V.; Török, P.; Toth, K.; Malik-Roffa, H.; Suntaxi, L. R. G.; Madar, S.; Kovacsics-Vari, G.; McIntosh-Buday, A.; Cando, P. D.; Sonkoly, J.
10.1101/2025.05.05.652257 — ecology — Posted on 2025-05-10
3900 Separable global and local beta burst dynamics in motor cortex of primates
Khanna, P.; farrokhi, b.; Choi, H.; Griffin, S.; Heimbuch, I.; Novik, L.; Thiesen, K.; Morrison, J. H.; Morecraft, R.; Ganguly, K.
10.1101/2025.05.05.652217 — neuroscience — Posted on 2025-05-10
3903 Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex
Huang, H.; Kay, K. N.; Gregg, N. M.; Valencia, G. O.; In, M.-H.; Kapeller, C.; Shu, Y.; Worrell, G. A.; Miller, K. J.; Hermes, D.
10.1101/2025.05.05.652264 — neuroscience — Posted on 2025-05-10
3904 Lrrns define a visual circuit underlying brightness and contrast perception
Putti, E.; Faini, G.; Dang, J. T.-M.; Eggeler, F.; Savaliya, J. H.; Duroure, K.; Vougny, J.; Bahl, A.; Lichtman, J. W.; Engert, F.; Boulanger-Weill, J.; Del Bene, F.; Albadri, S.
10.1101/2025.05.05.652281 — neuroscience — Posted on 2025-05-10
3908 A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system
Taranenko, D.; Kotovskaya, O.; Kuznedelov, K.; Yanovskaya, D.; Demkina, A.; Fardeeva, S.; Mamontov, V.; Vierra, K.; Burman, N.; Li, D.; Wang, M.; Wiedenheft, B.; Severinov, K.; Semenova, E.; Isaev, A.
10.1101/2025.05.07.652737 — microbiology — Posted on 2025-05-10
3914 Brain-wide cell-type-specific noradrenergic modulation of the transcriptome
Slater, C.; Lantin, T.; Wellman, S.; Jia, L.; Gonzalez, G.; McFaline-Figueroa, J. L.; Wang, Q.
10.1101/2025.05.09.653136 — neuroscience — Posted on 2025-05-10
3915 RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR
Matthews, E. A.; Russ, J. B.; Qian, Y.; Zhao, S.; Thompson, P.; Methani, M.; Vestal, M. L.; Huang, Z. J.; Southwell, D. G.
10.1101/2024.12.03.626590 — neuroscience — Posted on 2025-05-10
3916 Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution
Ma, R.; Kang, M.; Kim, G. H.; Kang, H.; Lee, S.; Yang, Y.; Lee, H. J.; Choi, S.; Kim, S.; Kim, S.; Jun, Y.; Kim, H.; Zhang, Y.; Kim, U. S.; Kang, H. R.; Kim, Y.; Lee, Y.; Chung, W.; Kim, E.; Jeon, M.; Hwang, G.-S.; Choi, J.; Jung, Y.; Kim, J. Y.; Kim, E.; Lee, K. J.; Han, K.
10.1101/2025.05.06.652352 — neuroscience — Posted on 2025-05-10
3917 APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoids
Fang, H.; Liao, X.; Bullen, C. K.; Pu, R.; Wang, H.; Condoleo, J.; Cheat, S.; Chen, X.; Zhang, Y.; Zhang, S.; Huo, D.; Lissit, K.; Yang, A.; Jarvis, K.; Neifert, S.; Huang, Y.; Bishai, W.; Jain, S. K.; Dawson, T.; Dawson, V. L.; Xu, J.
10.1101/2025.05.08.652864 — neuroscience — Posted on 2025-05-10
3919 A unified imaging-histology framework for superficial white matter architecture studies in the human brain
Hwang, Y.; Rodriguez-Cruces, R.; DeKraker, J.; Cabalo, D. G.; Leppert, I. R.; Thevakumaran, R.; Tardif, C. L.; Rudko, D. A.; Paquola, C.; Bazin, P.-L.; Bernasconi, A.; Bernasconi, N.; Concha, L.; Evans, A. C.; Bernhardt, B.
10.1101/2025.05.09.653169 — neuroscience — Posted on 2025-05-10
3924 Using deep learning to predict internalizing problems from brain structure in youth
Vandewouw, M. M.; Syed, B.; Barnett, N.; Arias, A.; Kelley, E.; Jones, J.; Ayub, M.; Iaboni, A.; Arnold, P. D.; Crosbie, J.; Schachar, R. J.; Taylor, M. J.; Lerch, J. P.; Anagnostou, E.; Kushki, A.
10.1101/2024.11.28.625869 — neuroscience — Posted on 2025-05-09
3926 Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay
Xu, W.; Keith, A. M.; Ye, W.; Hu, X.; Southall, N.; Juan, M. J.; Ferrer, M.; Henderson, M. J.; Sexton, P. M.; Deganutti, G.; Eiden, L. E.
10.1101/2025.04.16.649181 — pharmacology and toxicology — Posted on 2025-05-09
3928 Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth
Ma, Y.; Ayyadhury, S.; Singh, S.; Vashishath, Y.; Ozdemir, C.; McKee, T. D.; Nguyen, N.; Basi, A.; Mak, D.; Gomez, J.; Huse, J. T.; Noor, S.; Winkowski, D.; Baird, R.; Weinberg, J. S.; Lang, F. F.; Burks, J.; Bozdag, S.; Seeley, E. H.; Ene, C. I.
10.1101/2025.04.30.651361 — cancer biology — Posted on 2025-05-09
3930 Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells
Safa, B. T.; Rosenbohm, J.; Esfahani, A. M.; Minnick, G.; Moghaddam, A. O.; Lavrik, N. V.; Huang, C.; Charras, G.; Kabla, A.; Yang, R.
10.1101/2024.07.31.606021 — biophysics — Posted on 2025-05-09
3931 Identification of non-canonical peptides with moPepGen
Zhu, C.; Liu, L. Y.; Ha, A.; Yamaguchi, T. N.; Zhu, H.; Hugh-White, R.; Livingstone, J.; Patel, Y.; Kislinger, T.; Boutros, P. C.
10.1101/2024.03.28.587261 — bioinformatics — Posted on 2025-05-09
3938 FAM210B regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis
Perfetto, M.; Ishfaq, M.; Mohideen, A.; Rondelli, C. M.; Gillis, S.; Tejero, J.; Stratman, A. N.; Riggins, R. B.; Yien, Y. Y.
10.1101/2023.09.26.559581 — developmental biology — Posted on 2025-05-09
3939 Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance
Cole, C. G.; Zhang, Z. J.; Dommaraju, S. R.; Dong, Q.; Pope, R. L.; Son, S. S.; McSpadden, E. J.; Woodson, C. K.; Lin, H.; Dylla, N. P.; Sidebottom, A. M.; Sundararajan, A.; Mitchell, D. A.; Pamer, E. G.
10.1101/2025.05.06.652565 — microbiology — Posted on 2025-05-09
3940 Mesolimbic dopamine ramps reflect environmental timescales
Floeder, J. R.; Jeong, H.; Mohebi, A.; K Namboodiri, V. M.
10.1101/2024.03.27.587103 — neuroscience — Posted on 2025-05-09
3946 circEPSTI1 Enables Dengue Innate Immune Evasion by Sponging miR-942-5p, a Repressor of AKT1 and the Viral Genome
Das, N.; Krishnamoorthy, P.; Junghare, K. R.; Raj, A. S.; Saha, P.; Pal, K.; Adhya, S.; Garg, A.; Khetan, D.; Kumar, A.; Kumar, H.
10.1101/2025.05.05.652247 — immunology — Posted on 2025-05-09
3947 Early downregulation of HC-specific genes in the vestibular sensory epithelium during chronic ototoxicity
Borrajo, M.; Greguske, E. A.; Maroto, A. F.; Palou, A.; Gimenez-Esbri, V.; Sedano, D.; Gut, M.; Esteve-Codina, A.; Martin-Mur, B.; Barrallo-Gimeno, A.; Llorens, J.
10.1101/2025.05.05.652224 — neuroscience — Posted on 2025-05-09
3949 MITF-Independent Melanocyte Progenitors are Highly Susceptible to GNAQ-induced Uveal Melanoma in Adult Zebrafish
Yevdash, J. I.; Moore, R.; Li, Z.; Campbell-Hanson, K. R.; Robinson, D.; Gutelius, D.; Moore, S. P. G.; Friend, D.; O'Toole, I.; Cornell, R. A.; Lang, D.; Weigel, R. J.; Kenny, C.
10.1101/2025.05.05.652300 — cancer biology — Posted on 2025-05-09
3951 Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Giladi, M.; Kredi, S.; Guardiani, C.; Aviram, L.; Vankova, P.; Man, P.; Giacomello, A.; Haitin, Y.
10.1101/2025.05.09.652838 — biochemistry — Posted on 2025-05-09
3952 Isoswitching drives the aging process in human brains
Erdogdu, B.; Ji, H. J.; Rudnick, Z. C.; Pertea, M.; Salzberg, S.
10.1101/2025.05.05.652255 — genomics — Posted on 2025-05-09
3956 Endophilin mediated endocytosis and Epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells
Sharma, P.; Tanwar, M.; Choudhary, E.; Sundaram, N. M.; Ojha, D.; Mishra, L.; Nain, M.; Rode, A.; Prasad, V. M.; Vrati, S.; Kalia, M.
10.1101/2025.05.08.652984 — microbiology — Posted on 2025-05-09
3957 Genome-wide binding of the cyclic AMP receptor protein in enteroaggregative Escherichia coli suggests a role in modulating virulence
Alhammadi, M. M.; Hothersall, J.; Lloyd, G. S.; Titman, S. V.; Guest, T.; Browning, D. F.; Grainger, D. C.; Busby, S. J. W.; Haycocks, J. R. J.
10.1101/2025.05.09.652842 — microbiology — Posted on 2025-05-09
3959 Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1
Banas, V.; Seehra, K.; Mahoney, M.; Kyriukha, Y.; Alisio, C.; Fath, M.; Han, Z.; Bricker, T. L.; Tartell, M.; Whelan, S. P. J.; Boon, A.; Janetka, J. W.
10.1101/2025.05.09.652710 — microbiology — Posted on 2025-05-09
3960 Metabolic reprogramming of protists within the microbiome of sinking particles
Yang, Q.; Endo, H.; Yang, Y.; Ebihara, A.; Yamada, Y.; Fukuda, H.; Nagata, T.; Ogata, H.
10.1101/2025.05.08.652973 — microbiology — Posted on 2025-05-09
3961 Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling
Cho, S. H.; Brookens, S. K.; Raybuck, A. L.; Meyer, K.; Paik, Y. C.; Hamilton, J. A.; Li, J.; Kalecky, K.; Park, C.; Hicks, S. L.; Karijolich, J.; Bottiglieri, T.; Rathmell, J.; Mogilenko, D.; Scharer, C. D.; Boothby, M. R.
10.1101/2025.05.05.652119 — immunology — Posted on 2025-05-09
3962 NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion
Niou, Z.-X.; Yang, S.; Enriquez, A.; Sri, A.; Hines, C.; Tennessen, J. M.; Wu, C.-S.; Huang, J.-Y.; Lu, H.-C.
10.1101/2025.05.05.652246 — neuroscience — Posted on 2025-05-09
3964 Success factors for inter- and transdisciplinary research. Lessons from a decade of studies on invasive aquatic species.
Adrian-Kalchhauser, I.; Bussmann-Charran, K.; N'Guyen, A.; Hirsch, P. E.; Wiegleb, j.; Bergmann, L.; Burkhardt-Holm, P.
10.1101/2025.05.05.652198 — scientific communication and education — Posted on 2025-05-09
3966 Intracellular Delivery of Bone Nanoparticles to Mitigate Irradiation-Induced Damage in Bone Marrow Mesenchymal Stem Cells
Wang, B.; Ma, X.; Nguyen, C.; Stellpflug, A.; Li, S.; Han, L.; Frei, A.; Himburg, H.; Gu, L.; Dong, P.; Wang, S.; Mak, M.; Wu, R.
10.1101/2025.05.05.652269 — bioengineering — Posted on 2025-05-09
3967 A-eye: Automated 3D Segmentation of Healthy Human Eyeand Orbit Structures and Axial Length Extraction
Barranco, J.; Luyken, A. K.; Stachs, O.; Langner, S.; Franceschiello, B.; Bach Cuadra, M.
10.1101/2025.05.05.652187 — bioengineering — Posted on 2025-05-09
3968 Real time monitoring of hydrogenotrophic methanogenesis under deep saline aquifers conditions
Vidal, E.; Cario, A.; Jouvin, M.; Abadie, M.; Nguyen, O.; Erriguible, A.; Ranchou-Peyruse, A.; MARRE, s.
10.1101/2025.05.05.652176 — bioengineering — Posted on 2025-05-09
3969 Computational Assessment of Circularization Impact on Saxitoxin G-quadruplex Aptamer Performance
Gao, S.; Deng, B.; Cheng, D.; Zhou, R.; Wu, Y.; Jia, Y.; Xiao, B.; Yu, H.; Ma, Z.; Gao, Y.; Li, T.; Liu, G.; Zhang, Y.; Cheng, J.; Zhu, H.; Chen, H.; Wang, L.; Sun, M.
10.1101/2025.05.05.652042 — biochemistry — Posted on 2025-05-09
3970 Traits of Bathy Phytochromes and Application to Bacterial Optogenetics
Bohm, C.; Lehtinen, K.; Multamaki, E.; Vanhatalo, R.; Brander, O.; Meier, S. S. M.; Rumfeldt, J.; Moglich, A.; Takala, H.
10.1101/2025.05.05.652137 — biochemistry — Posted on 2025-05-09
3971 APPLE-MS: A affinity purification-mass spectrometry method assisted by PafA-mediated proximity labeling
Luo, S.; Xie, L.; Yang, L.; Hu, Z.; Wang, L.; Wang, Y.; Li, Q.; Guo, S.; Tao, S.-c.; Jiang, H.
10.1101/2025.05.06.652320 — biochemistry — Posted on 2025-05-09
3973 Nicking Loop™: An infinite amplification of single-stranded circular DNA
Adamusova, S.; Laine, N.; Korkiakoski, A.; Hirvonen, T.; Musku, A.; Rantasalo, T.; Kim, J.; Blomster, J.; Laine, J.; Tamminen, M.; Pursiheimo, J.-P.
10.1101/2025.05.08.652165 — molecular biology — Posted on 2025-05-09
3974 CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred
Sünderhauf, D.; Ringger, J. R.; Payne, L. J.; Pinilla-Redondo, R.; Gaze, W. H.; Brown, S. P.; van Houte, S.
10.1101/2025.05.09.653016 — microbiology — Posted on 2025-05-09
3975 Profiling Bile Acids in the Stools of Humans and Animal Models of Cystic Fibrosis
Carmichael, M.; Valls, R.; Soucy, S.; Sanville, J.; Madan, J.; Surve, S.; Sundrud, M. S.; O'Toole, G.
10.1101/2025.05.08.651222 — microbiology — Posted on 2025-05-09
3976 Discovery of a Novel Coltivirus in a Newly Identified Bat Bug Species (Heteroptera: Cimicidae) in Cambodia
Siegers, J. Y.; Auerswald, H.; Maquart, P.-O.; Szentivanyi, T.; Guillebaud, J.; Hoem, T.; Suor, K.; Pum, L.; Khun, L.; Nuon, S.; Chea, K.; Heang, V.; Bienes, K. M.; Nouhin, J.; Boyer, S.; Karlsson, E. A.
10.1101/2025.05.09.652812 — microbiology — Posted on 2025-05-09
3980 Deltaviruses spread through a viral Trojan Horse
McKellar, J.; Fouillen, A.; Lyonnais, S.; Seigneuret, F.; Blanchard, M.-P.; Trullo, A.; Kumarasinghe, L.; De Rossi, S.; Sleiman, R.; Desagher, S.; Gaudin, R.; de Rocquigny, H.; Granier, S.; Hepojoki, J.; Majzoub, K.
10.1101/2025.05.09.653040 — microbiology — Posted on 2025-05-09
3981 A tripartite protein complex promotes DNA transport during natural transformation in firmicutes.
Dewailly, M.; Fauconnet, Y.; Ducrot, C.; Soulet, A.-L.; Campo, N.; Guerois, R.; Radicella, J. P.; Polard, P.; Andreani, J.; JOHNSTON, C. H. G.
10.1101/2025.05.09.652193 — microbiology — Posted on 2025-05-09
3982 A nasal vaccine candidate, based on S2 and N proteins from SARS-CoV-2, generates a broad antibody response systemic and at lower respiratory tract.
Lobaina, Y.; Chen, R.; Vazquez-Blomquist, D.; Suzarte, E.; Zhang, M.; Zhou, Z.; Lan, Y.; Guillen, G.; Li, W.; Perera, Y.; Hermida, L.
10.1101/2025.05.09.653001 — immunology — Posted on 2025-05-09
3984 Neural and Computational Mechanisms Underlying One-shot Perceptual Learning in Humans
Hachisuka, A.; Shor, J. D.; Liu, X. C.; Friedman, D.; Dugan, P.; Saez, I.; Panov, F. E.; Wang, Y.; Doyle, W.; Devinsky, O.; Oermann, E. K.; He, B. J.
10.1101/2025.05.09.635727 — neuroscience — Posted on 2025-05-09
3985 Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays
Sheth, U.; Harrison, R.; Ferber, K.; Rosenbaugh, E. G.; Bevis, A.; Khillan, R.; Benatar, M.; Bjorklund, N. L.; Di Daniel, E.; Harris, G. A.; Kahn, O. I.; Liu, Y.; Zetterberg, H.; Mitic, L. L.; Graham, D.; Gendron, T. F.
10.1101/2025.05.05.652212 — neuroscience — Posted on 2025-05-09
3988 A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models
Gao, J.; Bamidele, N.; Pires-Ferreira, D.; Destefano, A.; Tang, Q.; Cao, Y.; Xie, J.; Gao, G.; Gruntman, A.; Sontheimer, E.; Flotte, T.; Xue, W. J.
10.1101/2025.05.07.652636 — bioengineering — Posted on 2025-05-09
3989 A Platform for Mitochondrial Profiling in Enriched Kidney Segments Under Thermodynamic Control
Decker, S. T.; Opurum, P. C.; Choi, R. H.; Paula, V. L.; Kurian, A. S.; Stewart, D.; Nikolova, L. S.; Sanchez, A.; Al-Rabadi, L.; Ramkumar, N.; Fisher-Wellman, K. H.; Funai, K.
10.1101/2025.05.05.652276 — biochemistry — Posted on 2025-05-09
3991 Th9-endothelial cell crosstalk promotes inflammatory atherosclerotic cardiovascular disease
Baral, I.; Baumer, Y.; Burma, A.; Sylvester, M.; Jones, K.; Kitakule, M. M.; Dey, A.; Rodante, J.; Gutierrez-Huerta, C. A.; Taramangalam, B.; Perez, J. D.; Guo, L.; Grogan, A.; Shiraki, T.; Finn, A.; Son, A.; Cho, K.; Khillian, J.; Chen, M.; Mehta, N. N.; Frischmeyer-Guerrerio, P. A.; Milner, J. D.; Powell-Wiley, T. M.; Falduto, G. H.; Schwartz, D. M.
10.1101/2025.05.05.652112 — immunology — Posted on 2025-05-09
3992 γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis
Meca-Laguna, G.; Admasu, T. D.; Shankar, A.; Barkovskaya, A.; Collibee, I.; Krakauer, A.; Tran, T.; Rae, M.; Sharma, A.
10.1101/2025.05.05.652251 — immunology — Posted on 2025-05-09
3993 Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine
Woodburn, S. C.; Kuhn, A.; Dadosky, D. T.; Mueller, E.; Bollinger, J. L.; Gonzalez, R. M. S.; Robinson, J. E.; Vollmer, L. L.; Wohleb, E. S.
10.1101/2025.05.05.652266 — neuroscience — Posted on 2025-05-09
3994 The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
Callahan, A.; Mojumdar, A.; Hu, M.; Wang, A.; Griffith, A.; Huang, N.; Chua, X. Y.; Mroz, N. M.; Puterbaugh, R. Z.; Reilly, S. P.; Salomon, A. R.
10.1101/2025.05.05.652301 — systems biology — Posted on 2025-05-09
3997 Lineage-Specific Evolution, Structural Diversity, and Activity of R2 Retrotransposons in Animals
Hassan, N. T.; Van Treeck, B.; Rodriguez-Vargas, A.; Sheppard, A. E.; Adelson, D. L.; Collins, K.
10.1101/2025.05.05.652312 — evolutionary biology — Posted on 2025-05-09
4000 CellTune: An integrative software for accurate cell classification in spatial proteomics
Bussi, Y.; Shainshein, D.; Ovits, E.; Posner, S.; Azulay, N.; Maimon, N.; Keidar Haran, T.; Ben-uri, R.; Brown, C.; Schuldiner, N.; Yaniv, E.; Van Valen, D. A.; Milo, I.; Elhanani, O.; Schiemann, R.; Keren, L.
10.1101/2025.05.05.652215 — bioinformatics — Posted on 2025-05-09
4009 Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
Marocco, F.; Garbo, S.; Montaldo, C.; Colantoni, A.; Quattrocchi, L.; Gaboardi, G.; Sabarese, G.; Cicchini, C.; Lecce, M.; Carnevale, A.; Paolini, R.; Tartaglia, G. G.; Battistelli, C.; Tripodi, M.
10.1101/2024.11.15.623754 — molecular biology — Posted on 2025-05-09
4010 An integrative genomic and chemical similarity approach linking fungal secondary metabolites and biosynthetic gene clusters
Steffen, K.; Rangel-Grimaldo, M.; Sauters, T. J. C.; Rinker, D.; Raja, H. A.; Graf, T. N.; Gumilang, A.; Riedling, O. L.; Goldman, G.; Oberlies, N. H.; Rokas, A.
10.1101/2025.05.08.652894 — microbiology — Posted on 2025-05-09
4012 Characterisation of transgenic lines labelling reticulospinal neurons in larval zebrafish
Collins, E. M.; Silva, P. T.; Ostrovsky, A. D.; Renninger, S. L.; Tomas, A. R.; Diez del Corral, R.; Orger, M. B.
10.1101/2024.12.20.629714 — neuroscience — Posted on 2025-05-09
4016 Conservation of symmetry breaking at the level of chromatin accessibility between fly species with unrelated anterior determinants
Amiri, E. E.; Tenger-Trolander, A.; Li, M.; Julian, A. T.; Kasan, K.; Sanders, S. A.; Blythe, S. A.; Schmidt-Ott, U.
10.1101/2025.01.13.632851 — developmental biology — Posted on 2025-05-09
4017 Sex-dependent neural plasticity in response to damage
Recatala-Martinez, M.; Bosch, M.; Gaspar, P.; Mineo, A.; Rios, S.; Miguel-Aliaga, I.; Morey, M.
10.1101/2025.05.05.652027 — neuroscience — Posted on 2025-05-09
4020 TS2CG as a membrane builder
Schuhmann, F.; Stevens, J. A.; Rahmani, N.; Lindahl, I.; Brown, C. M.; Brasnett, C.; Anastasiou, D.; Bravo Vidal, A.; Geiger, B. J.; Marrink, S.-J.; Pezeshkian, W.
10.1101/2025.04.16.649160 — biophysics — Posted on 2025-05-09
4022 An Accessible 3D HepG2/C3A Liver Spheroid Model Supporting the Complete Intrahepatocytic Lifecycle of Plasmodium falciparum
Caygill, C. H.; Alqurashi, S. O.; Adolfi, A.; Carson, J.; Sturm, A.; Evans, D. S.; Jinks, J. B.; Dechering, K. J.; Reimer, L.; Pennington, S. H.; Sharma, P.; Ward, S. A.; Biagini, G.
10.1101/2024.11.06.621813 — microbiology — Posted on 2025-05-09
4023 White matter microstructure and macrostructure brain charts across the human lifespan
Kim, M. E.; Gao, C.; Ramadass, K.; Newlin, N. R.; Kanakaraj, P.; Bogdanov, S.; Rudravaram, G.; Archer, D.; Hohman, T. J.; Jefferson, A. L.; Morgan, V. L.; Roche, A.; Englot, D. J.; Resnick, S. M.; Beason-Held, L. L.; Cutting, L.; Barquero, L. A.; D'arcangel, M. A.; Nguyen, T. Q.; Humphreys, K. L.; Niu, Y.; Vinci-Booher, S.; Cascio, C. J.; The HABS-HD Study Team, ; Alzheimers Disease Neuroimaging Initiative, ; The BIOCARD Study Team, ; Li, Z.; Vandekar, S. N.; Zhang, P.; Gore, J. C.; Landman, B. A.; Schilling, K. G.
10.1101/2025.05.08.652953 — neuroscience — Posted on 2025-05-09
4024 Conserved and lineage-restricted gene regulatory programs modulate developmental cnidocyte specification in Nematostella vectensis.
Danladi, B.; Al-Shaer, L.; Havrilak, J. A.; Faltine-Gonzalez, D. Z.; Jia, K.; Forwood, W.; Dubuc, T.; Musser, J.; Layden, M. J.
10.1101/2025.05.08.652877 — evolutionary biology — Posted on 2025-05-09
4026 Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression
Rusch, J.; Thanintorn, N.; Kuok, C.; Tsatskis, Y.; Hou, H.; Wilson, M. D.; Julick, C.; McNeill, H.
10.1101/2025.05.08.652952 — developmental biology — Posted on 2025-05-09
4027 Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera
Ronceray, N.; Bennani, S.; Mitsioni, M. F.; Siegel, N.; Marcaida, M. J.; Bruschini, C.; Charbon, E.; Roy, R.; Dal Peraro, M.; Acuna, G. P.; Radenovic, A.
10.1101/2024.09.17.613468 — biophysics — Posted on 2025-05-09
4031 Parsing glomerular and tubular structure variability in high-throughput kidney organoid culture
Uusi-Rauva, K.; Pirttiniemi, A.; Hassinen, A.; Trokovic, R.; Lehtonen, S.; Kallijarvi, J.; Lehto, M.; Fellman, V.; Groop, P.-H.
10.1101/2025.05.05.652160 — developmental biology — Posted on 2025-05-09
4033 METTL9 sustains vertebrate neural development primarily via non-catalytic functions
Pandolfini, L.; Codino, A.; Spagnoletti, L.; Olobardi, C.; Cuomo, A.; Santos- Rosa, H.; Palomba, M.; Margaroli, N.; GIROTTO, S.; Scarpelli, R.; Luan, S.-L.; Crocco, E.; Bianchini, P.; Bannister, A. J.; Gustincich, S.; Kouzarides, T.; Rizzo, R.; Barbieri, I.; Cremisi, F.; Vignali, R.
10.1101/2025.05.05.652220 — developmental biology — Posted on 2025-05-09
4035 IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition
Salloum, Y.; Gros, G.; Quintero-Castillo, K.; Garcia Baudino, C.; Rabahi, S.; Janardhana Kurup, A.; Diabangouaya, P.; Perez-Pascual, D.; Morales, R. A.; Boekhorst, J.; Villablanca, E.; Ghigo, J.-M.; Feijoo, C. G.; Brugman, S.; Hernandez Cerda, P. P.
10.1101/2025.05.05.652124 — immunology — Posted on 2025-05-09
4036 DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci
Rambarack, N.; Fodder, K.; Murthy, M.; Toomey, C.; de Silva, R.; Heutink, P.; Humphrey, J.; Raj, T.; Lashley, T.; Bettencourt, C.
10.1101/2025.01.21.634065 — neuroscience — Posted on 2025-05-09
4039 SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer
Nakamichi, S.; von Muhlinen, N.; Yamada, L.; Melamed, J. R.; Papp, T. E.; Parhiz, H.; Weissman, D.; Horikawa, I.; Harris, C. C.
10.1101/2025.05.05.652234 — cancer biology — Posted on 2025-05-09
4041 Molecular mechanism of exchange coupling in CLC chloride/proton antiporters
Aydin, D.; Chien, C.-T.; Kreiter, J.; Nava, A.; Portasikova, J. M.; Fojtik, L.; Salcedo, C. M.; Man, P.; Dror, R. O.; Chiu, W.; Maduke, M.
10.1101/2025.05.08.652968 — biophysics — Posted on 2025-05-09
4043 Erasable Synthetic Serum Markers
Nouraein, S.; Lee, S.; Li, H.; Saenz, V.; Raisley, E. K.; Costa, V. D.; Szablowski, J. O.
10.1101/2025.05.08.652140 — bioengineering — Posted on 2025-05-09
4049 The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.
Kitto, E. S.; Huang, S.; Bhandari, M.; Tian, C.; Cox, R. L.; Beydoun, S.; Wang, E.; Shave, D.; Miller, H. A.; Easow, S. A.; Henry, E.; Schaller, M. L.; Leiser, S. F.
10.1101/2025.05.04.652087 — physiology — Posted on 2025-05-09
4050 Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia
Koedijk, J. B.; Barneh, F.; Meesters-Ensing, J. I.; van Tuil, M.; Sonneveld, E.; Lambo, S.; Perzolli, A.; Schweighart, E. K.; Ferrao Blanco, M. N.; van der Meulen, M.; Deli, A.; Haasjes, E.; Bang Christensen, K.; de Groot-Kruseman, H. A.; Meshinchi, S.; Hasle, H.; Belderbos, M.; Luesink, M.; Goemans, B. F.; Nierkens, S.; Hehir-Kwa, J.; Zwaan, C. M.; Heidenreich, O.
10.1101/2025.05.04.652110 — cancer biology — Posted on 2025-05-09
4051 Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers
Kim, J.; Oh, J.; Jang, D.; Shin, S.; Lee, S.-J.; Lee, S. E.; Yang, Y.; Kim, D.; Choi, A.-J.; Jung, H. R.; Oh, Y.; Cho, S.-Y.
10.1101/2025.05.04.652100 — cancer biology — Posted on 2025-05-09
4052 Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy
Yamashita, K.; Brender, J. R.; Saida, Y.; Otowa, Y.; Kazumasa, H.; Ito, T.; Yamamoto, K.; Merkle, H.; Linehan, W. M.; Krishna, M. C.; Kishimoto, S.
10.1101/2025.05.04.652150 — cancer biology — Posted on 2025-05-09
4053 BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling
Dacheux, M.; Wu, M.-J.; Scherzer, M. T.; Nillson, M.; Murphy, B.; Schuman, S.; Ju, Z.; Bivona, T.; Lito, P.; Gumbleton, M.; Puri, S.; Akerley, W.; Wang, J.; Wang, K.; Heymach, J. V.; Kinsey, C. G.; Negrao, M. V.; McMahon, M.; Vaishnavi, A.
10.1101/2025.05.04.652129 — cancer biology — Posted on 2025-05-09
4054 Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer
Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.
10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-05-09
4055 Deep learning inference of cell type-specific gene expression from breast tumor histopathology
Wang, A. T.; Dhruba, S. R.; Wang, K.; Campagnolo, E. M.; Shulman, E. D.; Ruppin, E.
10.1101/2025.05.04.652089 — cancer biology — Posted on 2025-05-09
4056 Medium-assisted tumbling controls bacteria exploration in a complex fluid
Urra, H.; Darnige, T.; Benoit-Gonin, X.; Laurent, J.; Dawson, A.; Poon, W. C. K.; Clement, E.
10.1101/2025.05.04.652133 — biophysics — Posted on 2025-05-09
4057 Micron-scale, liquid-liquid phase separation in ternary lipid membranes containing DPPE
Goetz, G. J.; Naomi, S.; Madrigal, A. M.; Chang, C. L. A.; Cornell, C. E.; Keller, S. L.
10.1101/2025.05.08.652930 — biophysics — Posted on 2025-05-09
4058 Loading causes molecular damage in fibrin fibers
Norouzi, S.; Lohr, M. J.; Mohamed, M. I.; Jennings, C. M.; Wang, D.; Ren, P.; Rausch, M. K.; Parekh, S. H.
10.1101/2025.05.08.652948 — biophysics — Posted on 2025-05-09
4059 Hierarchical Heterogeneities in Spatio-Temporal Dynamics of the Cytoplasm
Moeckel, C.; Biswas, A.; Reber, S.; Chechkin, A.; Zaburdaev, V.; Guck, J.
10.1101/2025.05.08.652886 — biophysics — Posted on 2025-05-09
4062 Generating 3D Models of Carbohydrates with GLYCAM-Web
Grant, O. C.; Wentworth, D.; Holmes, S. G.; Kandel, R.; Sehnal, D.; Wang, X.; Xiao, Y.; Sheppard, P.; Grelsson, T.; Coulter, A.; Miller, G.; Foley, B. L.; Woods, R. J.
10.1101/2025.05.08.652828 — biophysics — Posted on 2025-05-09
4064 A pseudouridine synthase shapes tRNA structural dynamics through both catalysis and remodeling
Dennis, E. M.; Nieves, N. E. C.; Vaaler, A. L.; Kadrmas, M.; Barry, M. L.; Garcia, D. M.; Widom, J. R.
10.1101/2025.05.06.652307 — biophysics — Posted on 2025-05-09
4068 Application of spatial transcriptomics across organoids: a high-resolution spatial whole-transcriptome benchmarking dataset
Nucera, M. R. R.; Charitakis, N.; Leung, R.; Leichter, A.; Tuano, N.; Walkiewicz, M.; Sawant, V.; Rowley, L.; Scurr, M.; Er, P.; Tan, K.; Sutton, R.; Ahmad, F.; Saxena, R.; Maytum, A.; Turner, D.; Voges, H.; Nim, H.; Sun, X.; Yang, B.; Li, K.; Ball, G.; Elefanty, A.; Lamande', S.; Lawlor, K.; Vanslambrouck, J.; Mills, R.; Ng, E.; Stanley, E.; Werder, R.; Little, M.; Elliott, D.; Porrello, E.; Faux, M.; Eisenstat, D.; Velasco, S.; Rossello, F.; Ramialison, M.
10.1101/2025.05.04.651803 — bioinformatics — Posted on 2025-05-09
4069 IsoBayes: a Bayesian approach for single-isoform proteomics inference
BOLLON, J.; SHORTREED, M. R.; JORDAN, B. T.; MILLER, R.; JEFFERY, E.; CAVALLI, A.; SMITH, L. M.; DEWEY, C.; SHEYNKMAN, G. M.; Tiberi, S.
10.1101/2024.06.10.598223 — bioinformatics — Posted on 2025-05-09
4079 Single-cell RNA sequencing reveals influences of rearing environment on cellular immunity in brown trout (Salmo trutta)
Ord, J.; Martinez, H. S.; Solbakken, M. H.; Berezenko, A.; Oberhaensli, S.; Talker, S. C.; Schmidt-Posthaus, H.; Adrian-Kalchhauser, I.
10.1101/2025.05.04.652114 — immunology — Posted on 2025-05-09
4084 Tracking White Matter Changes After Stereotaxic Radiosurgery inMiniature Pigs Using structural MRI, DTI, and FDG-PET
Chen, K.-H.; Yeh, C.-I.; Xiao, F.; Cheng, M.-F.; Yen, R.-F.; Ju, Y.-T.; Chen, Y.; Alder, J. R.; Barbosa, D.; Schneider, M. B.
10.1101/2025.05.04.652148 — neuroscience — Posted on 2025-05-09
4085 Deep three-photon functional imaging in the mouse cortex with adaptive optics
Atilgan, H.; Wang, J.; Hu, Q.; Tan, S.; Russell, B.; Booth, M. J.; Lak, A.
10.1101/2025.05.04.652136 — neuroscience — Posted on 2025-05-09
4090 A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes
Watanabe, Y. V.; Sussman, J. H.; Anami, T.; Hattori, M.; Yamane, S.; Nishikawa, M.; Sakai, Y.; Katsuda, T.
10.1101/2025.05.07.652591 — cell biology — Posted on 2025-05-08
4093 A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system
Taranenko, D.; Kotovskaya, O.; Kuznedelov, K.; Yanovskaya, D.; Demkina, A.; Fardeeva, S.; Mamontov, V.; Vierra, K.; Burman, N.; Li, D.; Wang, M.; Wiedenheft, B. B.; Severinov, K.; Semenova, E.; Isaev, A.
10.1101/2025.05.07.652737 — microbiology — Posted on 2025-05-08
4096 Pre-stimulus beta power mediates explicit and implicit perceptual biases in distinct cortical areas
Forster, C.; Stephani, T.; Grund, M.; Panagoulas, E.; Al, E.; Hofmann, S. M.; Nikulin, V. V.; Villringer, A.
10.1101/2024.06.12.598458 — neuroscience — Posted on 2025-05-08
4097 A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes.
Sangwan, S.; Rieder, H.; Moore, D.; Khanlou, N.; Novitch, B.; Geisberg, M.; Eisenberg, D.
10.1101/2025.05.05.652290 — neuroscience — Posted on 2025-05-08
4099 Discover the Maze-like Pathway for Glabridin Biosynthesis
Zhang, Z.; Li, W.; Meng, F.; Jin, Y.; Sun, W.; Kuang, Q.; Ren, S.; Liu, W.; Zhang, L.; Qin, L.; Lv, B.; Jia, H.; Li, C.
10.1101/2025.05.06.652391 — synthetic biology — Posted on 2025-05-08
4101 Atomic Conformational Dynamics and Actin-Crosslinking Function of Alpha-Actinin Revealed by SimHS-AFMfit
Ngo, K. X.; Sumikama, T.; Vuillemot, R.; Nguyen, H. G.; Uyeda, T.; Le, N. T. P.; Grudinin, S.
10.1101/2025.04.06.647477 — biophysics — Posted on 2025-05-08
4103 No evidence for disassortative mating based on HLA genotype in a natural fertility population
Meeks, G. L.; Scelza, B.; Kichula, K. M.; Berevoescu, C.; Hardy, K.; Farias, T. D.; Harrison, G. F.; Pollock, N. R.; Font-Porterias, N.; Prall, S.; Norman, P. J.; Henn, B. M.
10.1101/2025.05.06.652536 — evolutionary biology — Posted on 2025-05-08
4104 Dogs gone wild: habitat use and ecological impacts of feral dogs in sub-Antarctic Chile
Tebelmann, H.; Kaefer, S.; Pages, A. S.; Ruiz, A. C.; Volkart, N. S.; Ganslosser, U.
10.1101/2025.05.08.652634 — ecology — Posted on 2025-05-08
4105 High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation
Yi, C.; Sun, J.; Sun, M.; Zhu, L.; Ma, Y.; Wu, S.; Liu, Y.; Gao, S.; Zhang, M.; Zhang, Y.-H.; Wang, Z.; Tzung, H.; Zou, P.; Li, D.; Liu, B.; Fei, P.
10.1101/2023.11.25.568636 — cell biology — Posted on 2025-05-08
4106 Alignment of human behavior, brain, and AI models in the high-level valence processing of complex social scenes
Yargholi, E.; Mertens, L.; Van Hove, L. I.; Gunay, E. M.; Vennekens, J.; Van den Stock, J.; Op de Beeck, H.
10.1101/2025.05.08.651182 — neuroscience — Posted on 2025-05-08
4107 White matter microstructure and macrostructure brain charts across the human lifespan
Kim, M. E.; Gao, C.; Ramadass, K.; Newlin, N. R.; Kanakaraj, P.; Bogdanov, S.; Rudravaram, G.; Archer, D.; Hohman, T. J.; Jefferson, A. L.; Morgan, V. L.; Roche, A.; Englot, D. J.; Resnick, S. M.; Beason-Held, L. L.; Cutting, L.; Barquero, L. A.; D'arcangel, M. A.; Nguyen, T. Q.; Humphreys, K. L.; Niu, Y.; Vinci-Booher, S.; Cascio, C. J.; The HABS-HD Study Team, ; Alzheimers Disease Neuroimaging Initiative, ; The BIOCARD Study Team, ; Li, Z.; Vandekar, S. N.; Zhang, P.; Gore, J. C.; Landman, B. A.; Schilling, K. G.
10.1101/2025.05.08.652953 — neuroscience — Posted on 2025-05-08
4111 Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level
Wang, Y.; Kou, H.-C.; Kuang, X.; Yao, S.; Lesnar, P.; NG, L.; Li, Y.; El-Hifnawi, L.; Chen, N.; Zhang, K.; Li, E. M.; Ben Simon, Y.; Ding, S.-L.; Wang, Q.; Karlsson, T.; Delley, R.; Williams, G.; Xiong, W.; Chen, C.; Chen, K.; Huang, Z.; Yu, Z.-F.; Xu, W.; Ahmadinia, L.; Walling-Bell, S.; Andrade, J.; Gliko, O.; Sumbul, U.; Mallory, M.; Farrell, C.; Sutton, B.; Jin, K.; Yao, Z.; Esposito, L.; Sunkin, S.; Kruse, L.; Luo, Q.; Gong, H.; Li, A.; Qu, J.; Choi, H.; Mihalas, S.; Zhuang, J.; Zeng, H.; Sorensen, S. A.
10.1101/2025.05.08.652699 — neuroscience — Posted on 2025-05-08
4114 A census of anti-CRISPR proteins reveals AcrIE9 as an inhibitor of Escherichia coli K12 Type IE CRISPR-Cas system
Isaev, A.; Taranenko, D.; Kotovskaya, O.; Kuznedelov, K.; Yanovskaya, D.; Demkina, A.; Fardeeva, S.; Mamontov, V.; Vierra, K.; Burman, N.; Li, D.; Wang, M.; Wiedenheft, B. B.; Severinov, K.; Semenova, E.
10.1101/2025.05.07.652737 — microbiology — Posted on 2025-05-08
4115 Design and synthesis of nanocarriers containing posaconazole against etiological agents of mucormycosis
Panahi, P.; Pourdakan, O.; Zarrinnahad, H.; Mahmoudi, S.; Aghaie, G.; Hosseini, F.; Alemzadeh, S. A.; Malek Raeesi, M.; Mirhendi, H.; Mehravi, B.
10.1101/2025.05.08.652746 — microbiology — Posted on 2025-05-08
4117 Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function
Santiago-Carvalho, I.; Francisco, R.; Macedo, B. G.; Salgado, C. L.; Stoll, C. R.; Cione, M. P.; White, E.; Johnston, T.; Leff, C. L.; Silva, I.; de Souza, F. C.; D'Imperio Lima, M. R.; Lancaster, J. N.; Borges da Silva, H.
10.1101/2025.05.03.652022 — immunology — Posted on 2025-05-08
4118 Ischemic Injury Drives Tumor Growth via Accelerated Hematopoietic Aging
Newman, A. A. C.; Barcia Duran, J. G.; Von Itter, R.; Dalman, J. M.; Lim, B.; Gourvest, M.; Zahr, T.; Wang, K. M.; Zhang, T.; Albarracin, N.; Rubin, W.; Bozal, F.; Gildea, M. A.; van Solingen, C.; Moore, K. J.
10.1101/2025.05.03.652034 — immunology — Posted on 2025-05-08
4119 Targeting Lysosomal Dysfunction to Alleviate Plaque Deposition in an Alzheimer Disease Model
Fremuth, L. E.; van de Vlekkert, D.; Hu, H.; Weesner, J. A.; Annunziata, I.; d'Azzo, A.
10.1101/2025.04.28.651121 — neuroscience — Posted on 2025-05-08
4120 Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming
Murano, T.; Hagihara, H.; Tajinda, K.; Takao, K.; Takamiya, Y.; Katoh, K.; Robison, A. J.; Matsumoto, M.; Namihira, M.; Miyakawa, T.
10.1101/2025.05.02.651848 — neuroscience — Posted on 2025-05-08
4122 Simulated Solute Tempering 2
Stratmann, D.; Moroy, G.; Tuffery, P.; Murail, S.
10.1101/2024.10.03.613476 — biophysics — Posted on 2025-05-08
4128 Identity-by-descent captures Shared Environmental Factors at Biobank Scale
Marsico, F.; Buonaiuto, S.; Amos-Abanyie, E.; Chinthala, L.; Mohammed, A.; Genetics Center, R.; Rooney, R.; Williams, R. W.; Davis, R. L.; Finkel, T. H.; Brown, C. W.; Prins, P.; Colonna, V.
10.1101/2025.05.03.652048 — genomics — Posted on 2025-05-08
4130 In vitro inhibition of the CFTR ion channel in the cervix thickens cervical mucus
Looney, R. J.; Roberts, M.; Markovetz, M.; Godiah, R.; Yao, S.; Golgotiu, K.; Wei, S.; Cellucci, C.; Han, L.
10.1101/2024.10.14.618249 — cell biology — Posted on 2025-05-08
4134 m5C RNA Methylation Is Dysregulated by Oncogenic Herpesviruses via c-Myc Signaling to Counteract Host Antiviral Factors
Wu, Z.; Zhou, D.; He, Z.; Fiches, G.; Park, Y.; He, J.; Chen, J.; Shanaka, K.; Lepcha, T. T.; Desai, P. J.; Zhu, J.; Santoso, N.
10.1101/2025.05.07.652742 — microbiology — Posted on 2025-05-08
4136 The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo.
Tandon, N.; Gutierrez-Martinez, E.; Bourdely, P.; Anselmi, G.; Denisot, J.; Gerber, Y.; Helft, J.; Bens, M.; Saveanu, L.; Guermonprez, P.
10.1101/2025.05.03.652057 — immunology — Posted on 2025-05-08
4140 Synthesis and In Vitro Assessment of Triazole-Based Compounds as Potential Inhibitors of Herpes Simplex Virus Type 1
Mishra, N. U.; Sanap, K. K.; Sharma, P. C.; Kudale, T.; Kudale, J. V. T.; Biswas, A.; Bhatia, D. D.
10.1101/2025.05.03.652007 — biochemistry — Posted on 2025-05-08
4141 Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii
Rouleau, F. D.; Dube, A. K.; Pageau, A.; Desautels, L.; Dufresne, P. J.; Landry, C. R.
10.1101/2025.05.07.652661 — biochemistry — Posted on 2025-05-08
4144 Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging
Zhang, Z.; Epstein, A.; Schaefer, C.; Abdulraouf, A.; Jiang, W.; Zhou, W.; Cao, J.
10.1101/2025.05.04.652093 — genomics — Posted on 2025-05-08
4149 Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes
Richman, A. R.; Kogut, S.; Edwards, T.; Boyd, J.; Rodriguez, P.; Mariani, M.; Shipley, M. A.; Manuel, K. A.; Ye, Z. A.; Bloom, D. C.; Frietze, S.; Neumann, D. M.
10.1101/2025.05.08.652945 — microbiology — Posted on 2025-05-08
4151 A bacterial CARD-NLR immune system controls the release of gene transfer agents
Banks, E. J.; Bardy, P.; Tran, N. T.; Nguyen, P. M.; Maqbool, A.; Le, T. B. K.
10.1101/2025.05.08.652646 — microbiology — Posted on 2025-05-08
4152 HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways
Mason, S. J.; Sreeram, S.; Niazi, F.; Leskov, K.; Levine, A. D.; Karn, J.; Valadkhan, S.
10.1101/2025.05.08.651477 — microbiology — Posted on 2025-05-08
4153 Associations between floor material and E. coli contamination in rural Bangladeshi households
Tazin, S.; Islam, M.; Pickering, A. J.; Kwong, L. H.; Mertens, A.; Niven, C.; Arnold, B. F.; Hubbard, A. E.; Alam, M.; Sen, D.; Islam, S.; Rahman, M.; Unicomb, L.; Luby, S. P.; Benjamin-Chung, J.; Ercumen, A.
10.1101/2025.05.07.652756 — microbiology — Posted on 2025-05-08
4154 Characterization of the glycoproteins of novel fish influenza B-like viruses
Singh, G.; Huang, J.; Bhavsar, D.; Vasilev, K.; Ferguson, J.; Boons, G.-J.; Simon, V.; de Vries, R. P.; Han, J.; Ward, A.; Krammer, F.
10.1101/2025.05.08.652883 — microbiology — Posted on 2025-05-08
4155 An integrative genomic and chemical similarity approach linking fungal secondary metabolites and biosynthetic gene clusters
Steffen, K.; Rangel-Grimaldo, M.; Sauters, T. J. C.; Rinker, D.; Raja, H. A.; Graf, T. N.; Gumilang, A.; Riedling, O. L.; Goldman, G.; Oberlies, N. H.; Rokas, A.
10.1101/2025.05.08.652894 — microbiology — Posted on 2025-05-08
4156 MAIT cell responses to intracellular and extracellular pathogens are mediated by distinct antigen presenting cells
Haas, D.; Melamed, J.; LeBlanc, G.; Arun, N.; Perkowski, A. J.; Aube, J.; Mack, M.; Constantinides, M. G.
10.1101/2025.05.03.652000 — immunology — Posted on 2025-05-08
4157 Multi-step antibody class switching in a primary human response is restricted after IGHG2 and dependent on B cell maturation stage.
Garcia, G. M.; Ng, J. C.; Stewart, A. T.; Sinclair, E.; Blair, P.; Kateregga, D.; Gander, A.; Kipling, D.; Guo, D.; Servius, L.; Piper, C.; Baig, Z.; Fraternali, F.; Mauri, C.; Dunn-Walters, D.
10.1101/2025.05.07.652638 — immunology — Posted on 2025-05-08
4159 A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes.
Sangwan, S.; Rieder, H.; Moore, D.; Khanlou, N.; Novitch, B.; Geisberg, M.; Eisenberg, D.
10.1101/2025.05.05.652290 — neuroscience — Posted on 2025-05-08
4160 Adropin protects against cardiac metabolic remodeling and dysfunction in HFpEF
Mushala, B. A.; Stoner, M. W.; Manning, J. R.; Bugga, P.; Bhattarai, N.; Sharifi-Sanjani, M.; McMahon, B.; Vandevender, A.; Mullett, S. J.; Kaufman, B. A.; Shiva, S. S.; Zhang, C.; Goetzman, E. S.; Chan, S. Y.; Gelhaus, S. L.; Jurczak, M. J.; Scott, I.
10.1101/2025.05.03.652038 — physiology — Posted on 2025-05-08
4165 High-Throughput Multiomics Profiling of Model Systems Using the AVITI24 Platform
Lopez, T.; Honigfort, D.; Mah, A.; Thompson, C.; Dien, V.; Dawood, M.; Frankel, E.; Fuller, D.; Jamison, C.; Kelley, R.; Kwon, J.; Liu, Y.; Ren, P.; Saha, S.; Wang, H.; Wong, J.; Zhao, D.; Abtahi, M.; Altomare, A.; Bajari, R.; Bellizzi, A.; Bracamonte, S.; Bradfield, A.; Brown-Greaves, C.; Bui, C.; Charov, K.; Constandse, R.; Cullion, K.; Damron, W.; Dangelo, M.; Davis, L.; Dawood, N.; Dhonde, R.; Elango, K.; Espinosa, S.; Garcia, F.; Gavrila, V.; Gomez, L.; Hastings, D.; Hoang, D.; Juan, W.; Kia, A.; Kim, M.; Krivit, M.; Lama, R.; Mandla, K.; Martinez, A.; Mass, M.; Miller, A.; Neysmith, J.;
10.1101/2025.05.03.651997 — genomics — Posted on 2025-05-08
4166 No Evidence of Direct Activation of Human Neutrophil Responses by Multivalent Prefusion Trimeric SARS-CoV-2 Spike Protein ex vivo
Fortin, A.; Huot, S.; Caron, E.; Laflamme, C.; Pagliuzza, A.; Chomont, N.; Gilbert, C.; Zhang, B.; Kwong, P. D.; Pouliot, M.; Grandvaux, N.
10.1101/2025.05.08.652856 — immunology — Posted on 2025-05-08
4168 A computational framework for mapping isoform landscape and regulatory mechanisms from spatial transcriptomics data
Su, J.; Qu, Y.; Schertzer, M. D.; Yang, H.; Jiang, J.; Lhakhang, T.; Nelson, T. M.; Park, S.; Lai, Q.; Fu, X.; Choi, S.-W.; Knowles, D. A.; Rabadan, R.
10.1101/2025.05.02.651907 — bioinformatics — Posted on 2025-05-08
4169 BioMedTools: a language model-powered community for biomedical computational tools
Liu, S.; Xing, H.; Han, M.; Zhang, D.; Gong, L.; Liu, D.; Chen, J.; Cai, P.; Hu, Q.-N.
10.1101/2025.05.02.651919 — bioinformatics — Posted on 2025-05-08
4173 Resolving Inflammation: The Impact of Antiretroviral Therapy on Macrophage Traffic In and Out of the CNS.
Wallis, Z.; Midkiff, C.; Zhao, M.; Kim, S. O.; Amadeck, A.; Wang, Y.; Jakubowski, M.; Burdo, T.; Miller, A.; Li, Q.; Alvarez, X.; Blair, R.; Williams, K.
10.1101/2025.05.02.651872 — immunology — Posted on 2025-05-08
4174 Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation
Hovde, M. J.; Bolland, D. E.; Kleinsasser, C. D.; Shetty, M.; Blackwell, A. C.; Golovko, M. Y.; Golovko, S. A.; Brown, C. R.; Foster, J. D.; Vaughan, R. A.
10.1101/2025.05.02.651918 — neuroscience — Posted on 2025-05-08
4175 A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
Brann, D. H.; Tsukahara, T.; Tau, C.; Kalloor, D.; Lubash, R.; Thamarai Kannan, L.; Klimpert, N.; Kollo, M.; Escamilla-Del-Arenal, M.; Bintu, B.; Bozza, T.; Datta, S. R.
10.1101/2025.05.02.651738 — neuroscience — Posted on 2025-05-08
4178 Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development
Yan, B.; Yuan, Q.; Kaur, P.; Mckee, A. R.; Shabashvili, D. E.; Guryanova, O. A.
10.1101/2025.05.02.651715 — pathology — Posted on 2025-05-08
4181 EnrichSci: Transcript-guided Targeted Cell Enrichment for Scalable Single-Cell RNA Sequencing
Liao, A.; Zhang, Z.; Sziraki, A.; Abdulraouf, A.; Xu, Z.; Lu, Z.; Zhou, W.; Cao, J.
10.1101/2025.05.02.651937 — genomics — Posted on 2025-05-08
4182 WITHDRAWN: Investigation of coronaviruses, paramyxoviruses and poxviruses in free-ranging anteaters and armadillos: a search for the unknown and zoonotic implications
Martins, N. B.; Alves, M. H.; De Navasquez, L. M. L.; Linhares, Y. S.; Caiaffa, M. G.; Soresini, G.; Kluyber, D.; Yogui, D. R.; Alves, A. C.; Lobo, A. C. M.; Catao-Dias, J. L.; Benavides, J. A.; Desbiez, A. L. J.; Brandao, P. E.; Hora, A. S. d.
10.1101/2025.02.26.640290 — molecular biology — Posted on 2025-05-08
4183 In vivo production of an anti-HIV antibody from primate hematopoietic cells by non-viral knock-in
Castelli, J. M.; Poljakov, K.; Youngseo, J.; Cassidy, M. E.; Gray, M. D.; Sanchez Gaytan, J. N.; Enstrom, M. R.; Linton, J. D.; Rongvaux, A.; Taylor, J. J.; Adair, J. E.
10.1101/2025.05.02.651933 — immunology — Posted on 2025-05-08
4184 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy
Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — neuroscience — Posted on 2025-05-08
4187 A Toolbox for the Personalization of Plasmonic Photothermal Therapy in Orthotopic Mouse Tumor Models
Fernandez Esteberena, P. R.; Vilches, C.; Morales-Dalmau, J.; Mireles, M.; Martinez-Lozano, M. d. M.; de Miguel, I.; Casanovas, O.; Quidant, R.; Durduran, T.
10.1101/2025.05.02.651947 — biophysics — Posted on 2025-05-08
4193 Landscape genomics and demography of California Azolla
Song, M. J.; Tribble, C. M.; Gonzalez-Ramirez, I.; Freund, F.; Li, F.-W.; Rothfels, C. J.
10.1101/2025.05.02.651959 — ecology — Posted on 2025-05-08
4194 FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi
Bedard, C.; Pageau, A.; Fijarczyk, A.; Mendoza-Salido, D.; Alcaniz, A.; Despres, P.; Durand, R.; Plante, S.; Alexander, E.; Rouleau, F.; Jordan, D. F.; Jay, A.; Giguere, M.; Bernier, M.; Sharma, J.; Maroc, L.; Gervais, N.; Menon, A.; Gagnon-Arsenault, I.; Bakker, S.; Rhodes, J.; Dufresne, P.; Bharat, A.; Sellam, A.; De Luca, D.; Gerstein, A.; Shapiro, R.; Quijada, N.; Landry, C.
10.1101/2024.10.07.617009 — microbiology — Posted on 2025-05-08
4195 A biofilm-tropic Pseudomonas aeruginosa bacteriophage uses the exopolysaccharide Psl as receptor
Walton, B.; Abbodante, S.; Marshall, M. E.; Dobruchowska, J. M.; Alvi, A.; Gallagher, L. A.; Vallikat, N.; Zhang, Z.; Wozniak, D. J.; Yu, E. W.; Boons, G.-J.; Pearlman, E.; Rietsch, A.
10.1101/2024.08.12.607380 — microbiology — Posted on 2025-05-08
4198 Correlates of head-fixed orienting movements in mouse superior colliculus and substantia nigra pars reticulata
Doykos, T. K.; Yamauchi, T.; Buteau, A.; Hanson, S.; Dudman, J. T.; Felsen, G. K.; Stubblefield, E. A.
10.1101/2025.05.02.651955 — neuroscience — Posted on 2025-05-08
4199 Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer
Llevenes, P.; Chen, A.; Lawton, M. L.; Rondon-Ortiz, A. N.; Qiu, Y.; Seen, M.; Monti, S.; Denis, G. V.
10.1101/2024.10.10.617639 — cancer biology — Posted on 2025-05-08
4200 Not All Saliva Samples Are Equal: The Role of Cellular Heterogeneity in DNA methylation and Epigenetic Age Analyses with Biological and Psychosocial Factors
Chan, M. H.-M.; Meijer, M.; Merrill, S. M.; Fu, M. P. Y.; Lin, D.; MacIsaac, J. L.; Riis, J. L.; Granger, D. A.; Thomas, E. A.; Kobor, M. S.
10.1101/2024.11.08.621377 — bioinformatics — Posted on 2025-05-08
4202 GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells
Deng, C.; Elujoba-Bridenstine, A.; Song, A. T.; Ceplina, R. M.; Ostheimer, C. J.; Hahn, M. C. P.; Scarlett, C. O.; Tamplin, O. J.
10.1101/2025.04.30.651482 — cell biology — Posted on 2025-05-08
4205 Discovery of giant viruses as past and present infections of zoosporic fungi
Myers, J.; Schulz, F.; Rahimlou, S.; Yadav, V.; Amses, K.; Simmons, D. R.; Sun, S.; Orozco-Quime, M.; Heitman, J.; Stajich, J. E.; James, T.
10.1101/2024.01.04.574182 — microbiology — Posted on 2025-05-08
4209 Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration
Jiang, Y.; Sachdeva, K.; Goulbourne, C. N.; Berg, M. J.; Peddy, J.; Stavrides, P. H.; Pensalfini, A.; Pawlik, M.; Malapati, S.; Whyte, L. S.; Basavaraj, B. S.; Shivakumar, S.; Bleiwas, C.; Smiley, J. F.; Mathews, P. M.; Nixon, R. A.
10.1101/2024.09.19.613736 — neuroscience — Posted on 2025-05-08
4211 Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming
Murano, T.; Hagihara, H.; Tajinda, K.; Takao, K.; Takamiya, Y.; Katoh, K.; Robison, A. J.; Matsumoto, M.; Namihira, M.; Miyakawa, T.
10.1101/2025.05.02.651848 — neuroscience — Posted on 2025-05-08
4213 Neurospectrum: A Geometric and Topological Deep Learning Framework for Uncovering Spatiotemporal Signatures in Neural Activity
Bhaskar, D.; Zhang, Y.; Moore, J. L.; Gao, F.; Rieck, B.; Wolf, G.; Khasawneh, F.; Munch, E.; Noah, J. A.; Pushkarskaya, H.; Pittenger, C.; Greco, V.; Krishnaswamy, S.
10.1101/2023.03.22.533807 — neuroscience — Posted on 2025-05-08
4214 Mature neutrophils promote long-term functional recovery after spinal cord injury in a sex-dependent manner
Pacheco, M. R.; Tran, A. V.; Bradley, M.; Leal-Garcia, M. E.; Ozturgut, M.; Barnett, E. A.; Chakka, V.; Devaraj, S.; Kirchhoff, M.; Mulamba, T.; Thomas, K.; Vu, N. V.; McCreedy, D.
10.1101/2025.02.25.640256 — neuroscience — Posted on 2025-05-08
4216 How monitoring behavior can inform conservation? The case of Spix's macaws under human care
Marcuk, V.; Purchase, C.; Scholtyssek, K.; Amador, J.; Crosta, L.; Crosta, P.-S.; Gupta, B. K.; Hofer, H.; Courtiol, A.
10.1101/2025.05.02.651864 — animal behavior and cognition — Posted on 2025-05-08
4220 Plant functional groups and root traits are linked to exudation rates of mature temperate trees
Oh, Y. E.; Midgley, M. G.; McCormack, M. L.; Beidler, K. V.; McCall, M.; Henderson, S.; Braghiere, R. K.; Phillips, R. P.
10.1101/2024.08.01.606171 — ecology — Posted on 2025-05-08
4221 FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans
Bhat, U. S.; Surendran, S.; H, S.; Liu, J.; Xu, Y.; Tasnim, N.; Bhardwaj, A.; Scholz, M.; Babu, K.
10.1101/2025.05.02.651881 — neuroscience — Posted on 2025-05-08
4223 Warm and cool temperatures decrease early-life telomere length in wild pied flycatchers
Furic, C.; Marciau, C.; Hsu, B.-Y.; Cossin-Sevrin, N.; Fleitz, J.; Reichert, S.; Ruuskanen, S.; STIER, A.
10.1101/2025.05.02.651824 — zoology — Posted on 2025-05-08
4228 Single molecule imaging of transcription dynamics, RNA localization and fate in T cells
Lattanzio, M. V.; Sostaric, N.; Kanagasabesan, N.; Popovic, B.; Bradaric, A.; Wardak, L.; Guislain, A.; Savakis, P. E.; Tutucci, E.; Wolkers, M. C.
10.1101/2024.11.11.622939 — immunology — Posted on 2025-05-08
4231 Repositioning of polyubiquitin alters the pathologic tau filament structure
Watanabe, R.; Creekmore, B. C.; Darwich, N. F.; Xu, H.; Changolkar, L.; Hoxha, K.; Zhang, B.; O'Rourke, C. M.; Burslem, G. M.; Lee, V. M.-Y.; Chang, Y.-W.; Lee, E. B.
10.1101/2025.05.02.651930 — neuroscience — Posted on 2025-05-08
4232 ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis
Gomez Deza, J.; Nebiyou, M.; El Touny, L. H.; Alkaslasi, M. R.; Zuo, Z.; Wlaschin, J. J.; Nadal-Nicolas, F. M.; Slavutsky, A. L.; Lloyd, E. Y.; Hayashi, P. M.; Ashby, N.; Sohn, M.; Dale, R.; Li, W.; Cheng, K.; Rocha, P.; Le Pichon, C. E.
10.1101/2023.09.27.559856 — neuroscience — Posted on 2025-05-08
4234 Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers
Ahn, C.; Zhang, T.; Rode, T.; Yang, G.; Chugh, O. K.; Ellis, S.; Ghayur, S. J.; Mehta, S.; Salzman, R.; Jiang, H.; Parker, S.; Burant, C.; Horowitz, J. F.
10.1101/2025.05.02.651890 — physiology — Posted on 2025-05-08
4235 Early onset of Ca2+ waves and synchronization in multicellular clusters facilitate focal arrhythmogenesis in human heart failure
Kazakova, D.; Colman, M.; Pradhan, A.; Gudaitis, L.; Nys, L.; Cools, B.; Rega, F.; Vandenberk, B.; Terracciano, C. M.; Roderick, L.; Sipido, K.; Dries, E.
10.1101/2025.05.02.651991 — physiology — Posted on 2025-05-08
4239 Age-Dependent, Odorant-Specific Changes in Olfactory Sensitivity in an Alzheimer's Disease Mouse Model
Adachi, Y.; Katori, K.; Ishiyama, S.; Morikawa, S.; Saito, T.; Saido, T. C.; Ikegaya, Y.; Takeuchi, H.
10.1101/2025.05.02.651821 — pathology — Posted on 2025-05-08
4241 Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer
Wu, J.; Lai, Y.; Li, J.; Zhai, L.; Asthana, P.; Chen, L.; Chen, M.; Chen, B.; Gurung, S.; Lyu, J.; Zhang, Y.; Lin, L.; Huang, S.; Kuang, W.; Shi, H.; Luo, Y.; Kong, X.; Wong, S. H.; Chan, K. M.; Yuan, S.; Kwan, H. Y.; Yuan, X.; Huang, W.; Ruan, Y.; Lu, H.; Wong, C. C.; Lyu, A.; Bian, Z.; Ren, Y.; Wu, X.; Ma, Y.; Wong, H. L. X.
10.1101/2025.05.02.651972 — cancer biology — Posted on 2025-05-08
4242 Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909
Laughlin, Z. T.; Arifova, L.; Munoz-Tello, P.; Yu, X.; Karadi Giridhar, M. N.; Dong, J.; Harp, J. M.; Zu, D.; Kamenecka, T. M.; Kojetin, D. J.
10.1101/2025.05.04.651770 — biophysics — Posted on 2025-05-08
4244 Surforama: interactive exploration of volumetric data by leveraging 3D surfaces
Yamauchi, K. A.; Lamm, L.; Gaifas, L.; Righetto, R. D.; Litvinov, D.; Engel, B. D.; Harrington, K.
10.1101/2024.05.30.596601 — bioinformatics — Posted on 2025-05-08
4245 Functional alignment of protein language models via reinforcement learning
Blalock, N.; Seshadri, S.; Babbar, A.; Fahlberg, S. A.; Kulkarni, A.; Romero, P. A.
10.1101/2025.05.02.651993 — bioengineering — Posted on 2025-05-08
4246 GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner
Löbbert, A.; Lorz, N.; Matthees, E. S. F.; Rössler, P.; Hoffmann, C.; Gossert, A. D.
10.1101/2025.05.06.652336 — biochemistry — Posted on 2025-05-08
4247 Septin7 is essential in early hematopoiesis, but redundant at later stages
Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.
10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-05-08
4249 Performance evaluation of adaptive introgression classification methods
Romieu, J.; Camarata, G.; Crochet, P.-A.; de Navascues, M.; Leblois, R.; Rousset, F.
10.1101/2024.06.12.598278 — evolutionary biology — Posted on 2025-05-08
4250 Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome
Tsai, W.-C.; Peng, P.; Jhou, P.-S.; Tsai, Y.-C.; Hung, W.-W.; Lin, Y.-H.; Jhuo, S.-J.; Huang, T.-C.; Chou, L.-F.; LIN, T.-H.; Su, H.-M.; Lai, W.-T.; Lee, C.-H.; Wu, B.-N.; Lin, S.-F.; Hung, W.-C.
10.1101/2025.05.06.652555 — microbiology — Posted on 2025-05-08
4251 Preconditioning Matters: Enhancing or Impairing Antitumor Immunity with DC Vaccines
Kwon, E.; Namen, S.; Willoughby, C. J.; Kang, S.; Pandey, G.; Kim, A. B.; DeSelm, C. J.
10.1101/2025.05.02.651990 — immunology — Posted on 2025-05-08
4252 Seizure-induced Transient Disruptive Changes in Brain Microstructure
Takamiya, A.; Riemer, F.; Erchinger, V. J.; Korbmacher, M.; Bartsch, H.; Ousdal, O. T.; Maximov, I.; Dale, A.; Emsell, L.; Oedegaard, K. J.; Kessler, U.; Oltedal, L.
10.1101/2025.05.05.652221 — neuroscience — Posted on 2025-05-08
4253 Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming
Murano, T.; Hagihara, H.; Tajinda, K.; Takao, K.; Takamiya, Y.; Katoh, K.; Robison, A. J.; Matsumoto, M.; Namihira, M.; Miyakawa, T.
10.1101/2025.05.02.651848 — neuroscience — Posted on 2025-05-08
4254 Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms
Gomes, C.; Huang, K.-C.; Lavekar, S. S.; Harkin, J.; Prosser, C. G.; Fang, Y.; Kallem, C.; Oblak, A.; Zhang, C.; Meyer, J. S.
10.1101/2025.05.02.651934 — neuroscience — Posted on 2025-05-08
4255 A ubiquitous spectrolaminar motif across independent studies, including in the Mackey et al. dataset
Major, A. J.; Abdaltawab, A.; Phillips, J. M.; Wang, T.; Lee, E. K.; Lichtenfeld, M. J.; Chandrasekaran, C.; Saalmann, Y. B.; Maier, A.; Desimone, R.; Miller, E. K.; Bastos, A. M.; Mendoza-Halliday, D.
10.1101/2025.05.07.652644 — neuroscience — Posted on 2025-05-08
4256 Light of both high and low melanopic illuminance have positive effects on attention and alertness
Bjerrum, L. B.; Visted, E.; Nordhus, I. H.; Osnes, B.; Bjorvatn, B.; Bugge Kambestad, O.; Hansen, M. E.; Sorensen, L.; Flo-Groeneboom, E.
10.1101/2025.01.15.633100 — neuroscience — Posted on 2025-05-08
4259 Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution
Haque, R.; Setty, H.; Lorenzo, R.; Stelzer, G.; Rotkopf, R.; Salzberg, Y.; Kumar, S.; Goldman, G.; Nir Halber, S.; Schneidman, E.; Leifer, A. M.; Laurent, P.; Oren-Suissa, M.
10.1101/2024.12.27.630541 — neuroscience — Posted on 2025-05-08
4261 Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse
Medrano, S.; Almeida, L.; Ruiz-Perez, F.; Gutierrez-Hernandez, A.; Yamaguchi, H.; Matsuoka, D. M.; Yamaguchi, M.; Smith, J. P.; Wagamon, T.; Sequeira-Lopez, M.; Gomez, R. A.
10.1101/2025.05.02.651896 — physiology — Posted on 2025-05-08
4263 Topology, Kinetics and Inheritance in Clonal Colonies of Bone Marrow Stromal Cells
Allegrezza, A.; Beschi, R.; Caudo, D.; Cavagna, A.; Corsi, A.; Culla, A.; Donsante, S.; Giannicola, G.; Giardina, I.; Gosti, G.; Grigera, T. S.; Melillo, S.; Palmisano, B.; Parisi, L.; Postiglione, L.; Riminucci, M.; Rotondi, F. S.
10.1101/2025.05.02.651830 — biophysics — Posted on 2025-05-08
4267 Patterns of Aedes aegypti immature ecology and arboviral epidemic risks in peri-urban and intra-urban villages of Cocody-Bingerville, Cote d'Ivoire: insights from a dengue outbreak
Bire, Y. N.; Zahouli, J. Z. B.; Dibo, J. D. K.; Coulibaly, P. N.; Manouana, P. G.; Mavoungou, J. F.; Hellhammer, F.; Maganga, G. D.; Djogbenou, L. S.; Adegnika, A. A.; Borrmann, S.; Becker, S. C.; Toure, M.
10.1101/2025.05.05.652274 — ecology — Posted on 2025-05-08
4270 Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders
Giacomel, A.; Powell, T. R.; Duarte, R. R.; Nordio, G.; Williams, S. C. R.; Turkheimer, F. E.; Veronese, M.; Martins, D.; Dima, D.
10.1101/2025.05.06.652361 — neuroscience — Posted on 2025-05-08
4273 The Association Between SLIT2 in Human Vitreous Humor and Plasma and Neurocognitive Test Scores
Shoushtari, S. I.; Liaw, E.; Alluri, S.; Sheikh, Z.; Kumar, S.; Huynh, C.; Schmidt, I. M.; Ness, S.; Chen, X.; Siegel, N. H.; Waikar, S. S.; Stein, T. D.; Lu, W.; Subramanian, M. L.
10.1101/2025.05.03.652072 — neuroscience — Posted on 2025-05-08
4277 Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes
Dreute, J.; Stengel, J.; Becher, J.; van den Borre, D. R.; Pfisterer, M.; Bartkuhn, M.; Beutgen, V. M.; Ndreshkjana, B.; Gaertner, U.; Graumann, J.; Huck, M.; Klatt, S.; Leff, C. L.; Farin, H. F.; Nist, A.; Schmitz, R.; Stiewe, T.; Teply-Szymanski, J.; Wilhelm, J.; Cabrera-Orefice, A.; Schmitz, M. L.
10.1101/2025.05.02.651820 — cancer biology — Posted on 2025-05-08
4281 Male mice prefer to live on their own
Davies, J.; Jackson, M. G.; Hinchcliffe, J. K.; Mendl, M.; Robinson, E. S. J.
10.1101/2025.05.02.651815 — animal behavior and cognition — Posted on 2025-05-08
4283 Characterisation of cell cycle checkpoint kinases in Toxoplasma gondii
Johnson, M. K.; Chelaghma, S.; Lewis, W. H.; Koreny, L.; Waller, R. F.; Merrick, C. J.
10.1101/2024.09.10.612042 — microbiology — Posted on 2025-05-08
4289 Brain bases for navigating acoustic features
Billig, A. J.; Sedley, W.; Gander, P. E.; Kumar, S.; Lad, M. J.; Chait, M.; Mohammadi, Y.; Berger, J. I.; Griffiths, T.
10.1101/2025.02.10.636597 — neuroscience — Posted on 2025-05-08
4293 Scale-dependent brain age with higher-order statistics from structural magnetic resonance imaging
Carnero-Rosell, A.; Janssen, N.; Maselli, A.; Pereda, E.; Huertas-Company, M.; Kitaura, F.-S.
10.1101/2025.03.24.644902 — neuroscience — Posted on 2025-05-08
4296 Competing regulatory modules control the transition between mammalian gastrulation modes
Wehmeyer, A. E.; Schmitt, J. K.; Eggersdorfer, F.; Zissel, L.; Schröder, C. M.; Dias, A.; Schüle, K. M.; Probst, S.; Arias, A. M.; McDole, K.; Arnold, S. J.
10.1101/2025.05.07.652670 — developmental biology — Posted on 2025-05-08
4297 Developmental landscape of shark telencephalon sheds light on the evolution of telencephalic cell types and the ancient origin of Cajal-Retzius cells
Quintana-Urzainqui, I.; Oel, P.; Berger, T.; Pan, L.; Papadopoulos, N.; Serka, G.; Verbanac, A.; Boersig, M.; Torres-Sabino, D.; Rollan-Delgado, I. C.; Santangeli, L.; Kaessmann, H.; Arendt, D.
10.1101/2025.05.08.652169 — developmental biology — Posted on 2025-05-08
4299 Tracing the Spread of Celtic Languages using Ancient Genomics
McColl, H.; Kroonen, G.; Pinotti, T.; Barrie, W.; Koch, J.; Ling, J.; Demoule, J.-P.; Kristiansen, K.; Sikora, M.; Willerslev, E.
10.1101/2025.02.28.640770 — evolutionary biology — Posted on 2025-05-08
4302 Somatosensory high frequency oscillations across the human central nervous system
Bailey, E.; Nierula, B.; Stephani, T.; Waterstraat, G.; Curio, G.; Nikulin, V.; Eippert, F.
10.1101/2024.11.16.622608 — neuroscience — Posted on 2025-05-08
4303 Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal.
Bond, D. R.; Burnard, S. M.; Uddipto, K.; Hunt, K. V.; Harvey, B. M.; Steffens Reinhardt, L.; Lawlor-O'Neill, C.; Roper, E. A.; Humphries, S.; Murray, H. C.; Mannan, A.; Dun, M. D.; de Bock, C.; Bowden, N. A.; Enjeti, A. K.; Verrills, N. M.; Riveros, C.; Le Cao, K.-A.; Lee, H. J.
10.1101/2024.01.30.577864 — cancer biology — Posted on 2025-05-08
4307 Influence of past climate changes and human-mediated introduction on patterns of genetic diversity distribution of the Papuan nutmeg (Myristica argentea) Warb.
Kusuma, J.; Milaba, A. C.; Paramitha, A.; Malaval, V.; Sari, M. N.; Nurhuda, C.; Couderc, M.; Scarcelli, N.; Watts, J.; Duminil, J.
10.1101/2025.02.05.636754 — evolutionary biology — Posted on 2025-05-07
4308 Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages
Ma, S.; Yang, B.; Sun, Y.; Wang, X.; Guo, H.; Liu, R.; Ye, T.; Kang, C.; Chen, J.; Jiang, L.
10.1101/2024.10.07.616983 — microbiology — Posted on 2025-05-07
4310 Beyond dichotomy: ultrasonic vocalizations of rats convey more than sad and happy
Wada, R.; Hakataya, S.; Tachibana, R. O.; Shiramatsu, T. I.; Ito, T.; Kanno, K.; Koshiishi, R.; Matsumoto, J.; Saito, Y.; Toya, G.; Okabe, S.; Okanoya, K.
10.1101/2024.12.09.627446 — animal behavior and cognition — Posted on 2025-05-07
4317 Soma to neuron communication links stress adaptation to stress avoidance behavior
Witrado, J.; Gundrum, E.; Veroli, M. V.; Mullett, S. J.; Gelhaus, S. L.; Lamitina, T.
10.1101/2025.05.07.652728 — physiology — Posted on 2025-05-07
4318 Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth
Ma, Y.; Ayadhury, S.; Singh, S.; Vashishath, Y.; Ozdemir, C.; McKee, T. D.; Nguyen, N.; Basi, A.; Mak, D.; Gomez, J.; Huse, J. T.; Noor, S.; Winkowski, D.; Baird, R.; Weinberg, J. S.; Lang, F. F.; Burks, J.; Bozdag, S.; Seeley, E. H.; Ene, C. I.
10.1101/2025.04.30.651361 — cancer biology — Posted on 2025-05-07
4320 Targeted genomic surveillance of insecticide resistance in African malaria vectors
Nagi, S. C.; Lucas, E. R.; Ashraf, F.; Mugoya, T.; Lukyamuzi, E.; Summers, S.; Yee, C. K.; Jacob, C. G.; Nganga, H. N.; Pemberton, T.; Essandoh, J.; Lukindu, M.; Kabore, H.; Sawadogo, G.; Williams, J.; Van t Hof, A. E.; Hernandez-Koutoucheva, A.; Hubbart, C.; Rowlands, K.; Jeffreys, A.; Goodwin, S.; Park, N.; Ariani, C.; Egyir-Yawson, A.; Goncalves, S.; Rajatileka, S.; Rockett, K.; Simpson, V. J.; Miles, A.; Weetman, D.; Kayondo, J.; Nolan, T.; Donnelly, M. J.
10.1101/2025.02.14.637727 — genomics — Posted on 2025-05-07
4322 Growth Factor-Independent mTORC1 Signaling Promotes Primary Cilia Length via Suppression of Autophagy
Shin, J.; Cormerais, Y.; Tighanimine, K.; Niroula, P.; Cisse, M. Y.; Lapp, S. C.; Kalafut, K. C.; Schrotter, S.; Manning, B. D.
10.1101/2025.05.07.652626 — cell biology — Posted on 2025-05-07
4324 SmartEM: machine-learning guided electron microscopy
Meirovitch, Y.; Chandok, I. S.; Park, C. F.; Potocek, P.; Mi, L.; Sawmya, S.; Li, Y.; Athey, T. L.; Susoy, V.; Karlupia, N.; Wu, Y.; Berger, D. R.; Schalek, R.; Bishop, C.; Xenes, D.; Martinez, H.; Matelsky, J.; Wester, B. A.; Pfister, H.; Schoenmakers, R.; Peemen, M.; Lichtman, J. W.; Samuel, A.; Shavit, N.
10.1101/2023.10.05.561103 — neuroscience — Posted on 2025-05-07
4328 The Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle
Ahn, A.; Kim, J. J.; Slusher, A. L.; Ying, J. Y.; Zhang, E. Y.; Ludlow, A. T.
10.1101/2024.11.21.624690 — physiology — Posted on 2025-05-07
4330 Tissue engineered endothelial keratoplasty with controlled endothelial cell density: proof of concept and paving the way for super TEEKs
Aouimeur, I.; Coulomb, L.; Fraine, S.; HE, Z.; Bonnet, G.; Sagnial, T.; Travers, G.; XXX, S.; Mauclair, C.; Moisan, A.; Gain, P.; thuret, G.; Corantin, M.
10.1101/2025.05.01.651674 — bioengineering — Posted on 2025-05-07
4331 Argonaute-siRNA loading via the RNA-binding protein RDE-4 in C. elegans
Knittel, T. L.; Montgomery, B. E.; Sprister, R. A.; Magelky, C. N.; Smith, M. J.; Soto-Ojeda, M.; Guthrie, M.; Phillips, C. M.; Montgomery, T.
10.1101/2025.05.06.652520 — biochemistry — Posted on 2025-05-07
4332 Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance
Canalda-Baltrons, A.; Silcocks, M.; Hall, M. B.; Theys, D.; Chang, X.; Viberg, L. T.; Sherry, N. L.; Coin, L.; Dunstan, S. J.
10.1101/2025.05.07.652570 — genomics — Posted on 2025-05-07
4335 A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity
Monzel, A. S.; Devine, J.; Kapri, D.; Enriquez, J. A.; Trumpff, C.; Picard, M.
10.1101/2025.02.03.635951 — cell biology — Posted on 2025-05-07
4336 FRAP-in-SR: Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 foci
Wu, C.; Manjarrez-Gonzalez, J. C.; Choudhury, M. S.; Shamkhi, N.; Ding, S.; Nair, V. M.; Draviam, V. M.
10.1101/2025.05.07.652606 — cell biology — Posted on 2025-05-07
4338 Agriculture alters protein evolution of nitrogen cycling genes in soil bacteria at a global scale
Ghaly, T. M.; Shah, B. S.; Coleman, N. V.; Elbourne, L.; Le Roux, J.; Gillings, M.; Paulsen, I. T.; Tetu, S. G.
10.1101/2025.05.07.652758 — microbiology — Posted on 2025-05-07
4339 Dynamics of Bacterial and Viral Transmission in Experimental Microbiota Transplantation
Weagley, J.; Cardenas, L. A. C.; Romani, A.; Sullender, M.; Aggarwal, S.; Makimaa, H.; Hogarty, M.; Rodgers, R.; Kennedy, E.; Foster, L.; Schriefer, L. A.; Baldridge, M. T.
10.1101/2025.01.15.633206 — microbiology — Posted on 2025-05-07
4341 Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance
Cole, C. G.; Zhang, Z. J.; Dommaraju, S. R.; Dong, Q.; Pope, R. L.; Son, S. S.; McSpadden, E. J.; Woodson, C. K.; Lin, H.; Dylla, N. P.; Sidebottom, A. M.; Sundararajan, A.; Mitchell, D. A.; Pamer, E. G.
10.1101/2025.05.06.652565 — microbiology — Posted on 2025-05-07
4342 A case-control neuroimaging investigation of chronic Zika virus-infected adults
Jun, S.; Bido-Medina, R. O.; Oviedo, J.; Miches, I.; Llano, D.; Tusen, L.; Stoeter, P.; Rodriguez, M.; Sadaghiani, S.
10.1101/2025.03.05.641727 — neuroscience — Posted on 2025-05-07
4350 Multimodal imaging reveals multiscale mechanical interplay in vertebral endplate microarchitecture during intervertebral disc loading
Parmenter, A. L.; Newham, E.; Sharma, A.; Disney, C. M.; Deyhle, H.; Bosi, F.; Terrill, N. J.; Bay, B. K.; Pitsillides, A. A.; Gupta, H. S.; Lee, P. D.
10.1101/2024.08.19.608559 — bioengineering — Posted on 2025-05-07
4353 Ultrathin Liquid Cells for Microsecond Time-Resolved Cryo-EM
Curtis, W. A.; Hruby, J.; Kruger, C. R.; Barrass, S. V.; Drabbels, M.; Lorenz, U. J.
10.1101/2025.05.05.652279 — biochemistry — Posted on 2025-05-07
4354 Peptidic tryptophan halogenation by a promiscuous flavin-dependent enzyme
Rice, A. J.; Gadgil, M. G.; Bisignano, P.; Stein, R. A.; Mchaourab, H. S.; Mitchell, D. A.
10.1101/2025.01.12.632611 — biochemistry — Posted on 2025-05-07
4355 Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment
Mendiola, A. J. P.; Rutkowsky, J. M.; Neier, K. E.; Hakam, S.; Sharifi, O.; Donnelly, C.; Torres, C.; Hernandez, C.; Yasui, D. H.; Ramsey, J. J.; LaSalle, J. M.
10.1101/2025.05.01.651733 — animal behavior and cognition — Posted on 2025-05-07
4356 Convergent evolution of sex chromosomes in two palm species,Phoenix dactylifera and Kerriodoxa elegans.
TESSAROTTO, H.; Beule, T.; Cherif, E.; ORJUELA, J.; Farhat, P.; LINDSTROM, A.; LEMANSOUR, A.; Santoni, S.; Kafer, J.; ABERLENC, F.
10.1101/2024.06.27.600560 — evolutionary biology — Posted on 2025-05-07
4357 Ontogeny of the vagal gut-brain axis
Lough, K. J.; Knox, J. C.; Moy, S. S.; King, J. S.; Williams, S. E.
10.1101/2025.05.01.651736 — developmental biology — Posted on 2025-05-07
4365 Algal Betaine Triggers Bacterial Hydrogen Peroxide Production that Promotes Algal Demise
Narvaez-Barragan, D. A.; Yuda, L.; Lipsman, V.; Yahalomi, D.; Malitsky, S.; Segev, E.
10.1101/2025.05.07.652642 — microbiology — Posted on 2025-05-07
4368 Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach
Agnorelli, C.; Peill, J.; Sawicka, G.; Kurtin, D. L.; Shatalina, E.; Ahmad, K.; Wall, M. B.; Rua, C.; Godfrey, K.; Ertl, N.; Searle, G.; Zhou, K.; Weiss, B.; Fagiolini, A.; Carhart-Harris, R.; Matthews, P. M.; Rabiner, E.; Nutt, D.; Erritzoe, D.
10.1101/2025.05.01.651686 — neuroscience — Posted on 2025-05-07
4369 Chronic HDACi emends microglial differentiation and neurological disease in a mouse model of intellectual disability
Alam, M. S.; Padmanabhan, P. K.; McArdle, R.; Lopez-Ramirez, A.; MysoreRajashekara, A.; Knopp, J.; Kim, G.; Centeo, M. V.; Apkarian, A. V.; Swarup, V.; Haldar, K.
10.1101/2025.05.01.651719 — neuroscience — Posted on 2025-05-07
4370 PanScan: A Tool for Tertiary Analysis of Human Pangenome Graphs
Uddin, M.; Balan, B.; Hanif, M.; Hashmi, A.; Kumail, M.; Bineshaq, S.; Alyazeedi, T.; Naveed, R.; Murtaza, M.; Jamalalail, B.; Elsokary, H.; Alobathani, M.; Mohamed, N.; Kondaramage, D.; Advani, D.; Ibrahim, A.; Shiyas, S.; Sares, N.; Alkhnbashi, O.; Duplessis, S.; Almarri, M.; Nassir, N.; Alsheikhali, A.
10.1101/2025.05.01.651685 — bioinformatics — Posted on 2025-05-07
4374 Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata
Connell, S. J.; Crotts, S.; Reis, R.; Lensing, M.; Kahl, P.; Henderson, N.; Ayush, O.; Zhu, Z.; Ortolan, L. S.; Harty, J.; Goverman, J.; Jabbari, A.
10.1101/2025.05.07.650678 — immunology — Posted on 2025-05-07
4375 Staphylococcus aureus-Induced Degeneration of Nociceptive Neurons in Caenorhabditis elegans
DiLoreto, E. M.; Gonzalez, X.; Wani, K. A.; Shen, J.; Irazoqui, J. E.; Srinivasan, J. E.
10.1101/2025.05.01.651706 — neuroscience — Posted on 2025-05-07
4376 Alzheimer's disease risk gene Wwox protects against amyloid pathology through metabolic reprogramming
Lucas-Clarke, H. J.; Maddison, D. C.; Amadio, L.; Buhl, E.; O'Hare, K.; Regnault, C.; Peters, O. M.; Hodge, J. J. L.; Smith, G. A.
10.1101/2025.05.01.651195 — neuroscience — Posted on 2025-05-07
4377 Autophagy driven by VPS34 enables differentiated cell plasticity and cancer initiation
Ramos-Delgado, F.; Shalhoub, H.; Guyon, C.; Handschin, C.; Cerapio-Arroyo, P.; DAngelo, R.; Therville, N.; Villard, A.; Cayron, C.; Valle, C.; Sarot, E.; Dussere, N.; Di-Luoffo, M.; Rebours, V.; Couvelard, A.; Joffre, C.; de Oliveira, H.; Dufresne, M.; Thibault, B.; Guillermet-Guibert, J.
10.1101/2025.05.02.651270 — pathology — Posted on 2025-05-07
4378 Lysyl oxidase promotes actin-dependent neutrophil activation and cytotoxicity in diabetes: Implications for diabetic retinopathy
Agarwal, M.; Chandrakumar, S.; Santiago Tierno, I.; Lessieur, E. M.; Bollinger, Z. R.; Kern, T. S.; Ghosh, K.
10.1101/2025.05.02.651525 — pathology — Posted on 2025-05-07
4379 Miro1 knockout inhibits mouse breast cancer tumorigenesis
Termos, R.; Muskat, A.; Shannon, N.; McCoy, M.; Termos, A.; Palmer, C.; Chang, M. C.; Cunniff, B.
10.1101/2025.05.06.650999 — cancer biology — Posted on 2025-05-07
4380 Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3' Splice Site Interactions in Cancer Progression
Tankka, A.; Einstein, J. M.; Zhou, C. J.; Pham, V. N.; Zhang, Y.; Naritomi, J. T.; Nguyen, G. G.; Mizrahi, O.; Perelis, M.; Sarsam, J.; Tan, F. E.; Kaufman, D. S.; Antal, C. E.; Yeo, G. W.
10.1101/2025.05.01.651692 — cancer biology — Posted on 2025-05-07
4381 Regenie.QRS: computationally efficient whole-genome quantile regression at biobank scale
Wang, F.; Wang, C.; Wang, T.; Masala, M.; Fiorillo, E.; Devoto, M.; Cucca, F.; Ionita-Laza, I.
10.1101/2025.05.02.651730 — bioinformatics — Posted on 2025-05-07
4383 Data-driven feedback augments ultrasound nanotheranostics in brain tumors
Lee, H.; Menezes, V.; Zeng, S.; Kim, C.; Baseman, C. M.; Kim, J. H.; Padmanabhan, S.; Premdas, P.; Djeddar, N.; Bryksin, A. V.; Pandey, N.; Anastasiadis, P.; Kim, A. J.; MacDonald, T. J.; Bettegowda, C.; Woodworth, G. F.; Hermann, F. J.; Arvanitis, C.
10.1101/2025.05.01.651328 — bioengineering — Posted on 2025-05-07
4389 Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function
Prabhala, P.; Freiman, S.; Gvazava, N.; Sharma, J.; Wijk, S.; Kanszenbach, K.; Lang, S.; Cattani, R.; Wigen, J.; Bryder, D.; Soneji, S.; Flygare, J.; Tufvesson, E.; Bjermer, L.; Wagner, D. E.; Westergren-Thorsson, G.; Magnusson, M.
10.1101/2025.05.06.650933 — molecular biology — Posted on 2025-05-07
4390 Antibody Binding and Neutralizing Targets within the Predicted Structure of the Poxvirus Multiprotein Entry-Fusion Complex
Yu, H.; Resch, W.; Cotter, C. A.; Belghith, A. A.; Ignacio, M. A.; Earl, P. L.; Cohen, G. H.; Moss, B.
10.1101/2025.05.07.652617 — microbiology — Posted on 2025-05-07
4391 Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
Fry, L.; de Jesus, F. N.; Carneiro, M. B.; Roys, H.; Bowlin, A.; Peters, N. C.; von der Weid, P.-Y.; Weinkopff, T.
10.1101/2025.05.01.651666 — immunology — Posted on 2025-05-07
4392 The gonococcal vaccine candidate antigen NGO1701 is a N. gonorrhoeae periplasmic copper storage protein
Roe, S. K.; Mazgaj, R.; Zhu, T.; Esmaeeli, M.; Lewis, L. A.; Genco, C.; Waldron, K. J.; Massari, P.
10.1101/2025.05.01.651437 — immunology — Posted on 2025-05-07
4395 Chronic nicotine treatment enhanced cognition and reduced neuroinflammation in the gp120 transgenic mouse model of neuroHIV
Ayoub, S. M.; Dexter, T.; Noback, M.; Flesher, M. M.; Achim, C.; Fields, J. A.; Minassian, A.; Brody, A.; Young, J. W.
10.1101/2025.05.03.651604 — neuroscience — Posted on 2025-05-07
4402 miRNA-mRNA network analysis identifies PAX5 as a potential regulator of adaptive immune response in COPD
Gentili, M.; De Marzio, M.; Hobbs, B.; Hersh, C. P.; Ryu, M. H.; Kuijjer, M. L.; Cho, M. H.; Moll, M.; Tern, C.; Castaldi, P.; Glass, K.
10.1101/2025.05.06.651484 — systems biology — Posted on 2025-05-07
4404 Targeted Molecular MRI of Colorectal Cancer by Antibody Functionalized Hyperpolarized Silicon Particles
Whiting, N.; Hu, J.; Pudakalakatti, S.; McCowan, C.; Ramezani, S.; Davis, J.; Millward, N. Z.; Engel, B.; Liu, J.; Gellci, K.; Seo, H.; Brown, D.; Enriquez, J. S.; Menter, D. G.; Millward, S. W.; Gammon, S. T.; Piwnica-Worms, D.; Farach-Carson, M. C.; Carson, D.; Constantinou, P. E.; Bhattacharya, P.
10.1101/2025.05.06.651536 — cancer biology — Posted on 2025-05-07
4405 Insights into gallbladder cancer pathogenesis from a living organoid gallbladder cholangiocyte biorepository
Dutta, A.; Chowdhury, N.; Selvarajan, A. V.; Banerjee, P.; Kar, A.; Chandra, S.; Sunderam, U.; Ganguli, D.; Dutta, T.; Basak, D.; Satheeshkumar, S. J.; Ragate, A. S.; Krishnan, S.; Sen, S.; Roy, M. K.; Banerjee, S.; Srinivasan, R.; Roy, P.; Saha, V.; Dutta, A.; GuhaSarkar, D.
10.1101/2025.05.01.651639 — cancer biology — Posted on 2025-05-07
4408 GENETIC ENGINEERING THROUGH QUANTUM CIRCUITS: CONSTRUCTION OF CODES AND ANALYSIS OF GENETIC ELEMENTS BIOBLOQU
Pascoal, P. V.; Bambil, D.; Tacca, L. M. A. d.; Lima, R. N.; Oliveira, M. A. d.; Vainstein, M. H.; Rech, E.
10.1101/2025.05.02.651535 — bioinformatics — Posted on 2025-05-07
4410 Modeling host-microbe interactions in immunocompetent engineered human gut tissues
Lopez-Sandoval, R.; Harter, M. F.; Yu, Q.; Gaspa-Toneu, L.; Cubela, I.; Kromer, K.; Aubert, J.; Filip, A. M.; Kaltenbach, L.; Almato-Bellavista, M.; Akkerman, N.; Bollen, Y.; Munteanu, S.; Fidelin, J.; Augustin, A.; Schori, C.; Bickle, M.; Lutolf, M. P.; Beumer, J.; Recaldin, T.; Nikolaev, M.; Gjorevski, N.; Camp, J. G.
10.1101/2025.05.02.651468 — bioengineering — Posted on 2025-05-07
4412 Thermal proteome profiling identifies glucose binding proteins involved in metabolic disease
Ferguson, I. D.; Meservey, L. M.; Tien, V.; Miao, W.; Lopez-Pajares, V.; Porter, D. F.; Khavari, P.
10.1101/2025.05.06.651509 — biochemistry — Posted on 2025-05-07
4413 A Chromosome-Scale Genome of Nanomia septata Reveals Extensive Rearrangement But No Clear Driver of the Unique Colony-Level Organization of Siphonophores
Ahuja, N.; Schultz, D. T.; Destanovic, D.; Church, S. H.; Picciani, N.; Munro, C.; Kon-Nanjo, K.; Kon, T.; Manko, M. K.; Shi, W.; Haddock, S. H. D.; Simakov, O.; Dunn, C. W.
10.1101/2025.05.01.651713 — genomics — Posted on 2025-05-07
4415 Patterns of grass (Poaceae) species distribution and richness across India
Mande, M.; Joshi, A. A.; Paramjyothi, H.; Ratnam, J.; Sankaran, M.
10.1101/2025.05.06.651586 — ecology — Posted on 2025-05-07
4418 A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling
Iwasaki, K.; Carapeto, P.; Abarca, C.; Hela, F.; Sanjines, S.; Pena, S.; Le, S.; Pan, H.; Cahill, C.; Midha, A.; Diniz, J. A.; Baker, D.; Domanskyi, S.; Espinoza, S.; Pena, A.; Cigarroa, F. G.; Woolworth, J. L.; Chuang, J. H.; Garovic, V. D.; Kirkland, J.; Tchkonia, T.; Musi, N.; Kuchel, G. A.; Robson, P.; Aguayo-Mazzucato, C.
10.1101/2025.05.07.648438 — developmental biology — Posted on 2025-05-07
4419 Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Chudzik, K.; Guerreiro, I.; Kefalopoulou, S.; Abraham, A.; Schindler, M.; Ringel, A. R.; Nicodemi, M.; Solovei, I.; Chiariello, A. M.; Mundlos, S.; Kind, J.; Robson, M. I.
10.1101/2025.05.05.651267 — developmental biology — Posted on 2025-05-07
4420 An embryonic artery-forming niche reactivates in pulmonary arterial hypertension
Tian, W.; Wu, T. T.-H.; Gu, S.; Chang, J. L.; Huang, C.; Vinh, R.; Andruska, A. M.; Song, K. K.; Kim, D.; Zhu, Y.; Lee, S.; Pan, J.; Kao, P. N.; Desai, T.; Prince, L. S.; Butcher, L. D.; Jiang, X.; Rabinovitch, M.; Red-Horse, K.; Nicolls, M. R.
10.1101/2025.05.02.651303 — developmental biology — Posted on 2025-05-07
4421 Autophagy selectively clears ER in inflammation-induced muscle atrophy
Dueren, U. K.; Wei, A. A. J.; Gressler, A. E.; Popp, O.; Grumati, P.; Selbach, M.; Simon, A. K.; Sommer, T.
10.1101/2025.05.06.650963 — molecular biology — Posted on 2025-05-07
4422 Impact of Human Genetic Variation Underlying Resistance to Antigen-Specific Immunotherapy
Marone, R.; Asllanaj, E.; Capoferri, G.; Schwede, T.; Jeker, L. T.; Lepore, R.
10.1101/2025.05.02.651174 — immunology — Posted on 2025-05-07
4423 AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells
He, M.; DAulerio, R.; Pinho, L. G.; Doukoumopoulos, E.; Yong, T.; Vieira, R. C.; Oliveira, M.; Sedimbi, S.; Seitz, C.; Kuznetsov, N. V.; Zuriaga, M. A.; Kitamura, D.; Fuster, J. J.; Cotta-de-Almeida, V.; Strom, L.; Degn, S. E.; Westerberg, L.
10.1101/2025.05.02.651162 — immunology — Posted on 2025-05-07
4424 Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets
Derby, N.; Johnson, B. I.; Biswas, S.; Fischer, M.; Fancher, K. A.; Luevano-Santos, C.; Yusova, S.; Meyer, K. A.; Abraham, Y. M.; Lutz, S. S.; Fisher, C.; Pacheco, M. C.; Smedley, J. V.; Burwitz, B. J.; Sodora, D. L.
10.1101/2025.05.01.651668 — immunology — Posted on 2025-05-07
4425 Oxysterol Alterations in SOD1G93A ALS Rats: 25-Hydroxycholesterol and LPS-Binding Protein in Disease Progression
Lima, R. S.; Santos, R.; Chaves-Filho, A. B.; Trzan, I. F. L.; Inague, A.; Faria, R. L.; Dantas, L. S.; Pinto, I. F. D.; Medeiros, M. H. G.; Steiner, A. A.; Miyamoto, S.
10.1101/2025.05.05.650333 — neuroscience — Posted on 2025-05-07
4427 Self-Motion Perception Influences Postural Sway More than Environmental Motion Perception
Anson, E. R.; Critelli, K.; Chen, E.; Staab, J. P.; Carpenter, M. G.; Crane, B. T.
10.1101/2025.05.02.651511 — neuroscience — Posted on 2025-05-07
4428 Unraveling Cross-Cellular Communication in Cannabis sativa Sex Determination: A Network Ontology Transcript Annotation (Nota) Analysis.
Orozco, L. R.; Weaver, A. E.; Pauli, C. C.; Grassa, C. J.; Vergara, D.; Baptista, A.; White, K.; Emery, B. F.; Castro, N. R. M.; Guerrero, R. F.; Keegan, B. C.; Kane, N. C.
10.1101/2025.05.05.650505 — systems biology — Posted on 2025-05-07
4430 Dynamic Shape Modulation of Deflated and Adhered Lipid Vesicles
Wolfisberg, G. C.; Agudo-Canalejo, J.; Bittmann, P. C.; Dufresne, E. R.; Style, R. W.; Rebane, A. A.
10.1101/2025.05.06.650387 — biophysics — Posted on 2025-05-07
4432 Contrasted effects of human pressure on biodiversity in the UK: a multi-taxonomic assessment using airborne environmental DNA
Tournayre, O.; Littlefair, J. E.; Garrett, N. R.; Brown, A. S.; Allerton, J. J.; Cristescu, M. E.; Clare, E. L.
10.1101/2025.05.01.651649 — ecology — Posted on 2025-05-07
4434 WITHDRAWN: How Bacterial Vesicles Trigger Hearing Loss: The Role of Pyroptosis in Cochlear Damage
Xu, T.; Zhang, J.; Zhao, H.; Nong, H.; Yang, Q.; Yuan, Y.; Zhao, J.; Zhang, X.; Li, Y.; Tun, Z. M. M.; Bekale, L.; Cao, Z.
10.1101/2025.04.28.650954 — immunology — Posted on 2025-05-07
4435 Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function
Devlin, B.; Nguyen, D.; Ribeiro, D.; Grullon, G.; Clark, M.; Finn, A.; Ceasrine, A. M.; Oxendine, S.; Deja, M.; Shah, A.; Ati, S.; Schaefer, A.; Bilbo, S. D.
10.1101/2024.05.10.589920 — neuroscience — Posted on 2025-05-07
4437 A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
Sawhney, A. S.; Deskin, B. J.; Cai, J.; Gibbard, D.; Ali, G.; Utoft, A.; Qi, X.; Olson, A.; Hausman, H.; Sabol, L.; Holmberg, S.; Shah, R.; Warren, R.; De Langhe, S. P. J.; Benedito, R.; Inde, Z.; Sarosiek, K.; Lemire, E.; Haber, A. L.; Wang, L.; Wei, Z.; Brownfield, D. G.
10.1101/2025.04.28.650846 — developmental biology — Posted on 2025-05-07
4438 Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently from mesothelial fate.
Alsukari, S. H.; Ng, H. T.; Lang, L.; Lunn, S.; Beglinger, S.; Carr, L.; Boyes, M.; Turner, D. A.; Wilm, B.
10.1101/2024.08.08.607207 — developmental biology — Posted on 2025-05-07
4440 Identification and Overexpression of Endogenous Transcription Factors to Enhance Lipid Accumulation in the Commercially Relevant Species Chlamydomonas pacifica
Gupta, A.; Oliver, A.; Molino, J. V. D.; Wnuk-Fink, K. M.; Tessman, M.; Kang, K.; Santo, E. d. E.; Torres-Tiji, Y.; Burkart, M.; Mayfield, S.
10.1101/2025.05.01.651737 — systems biology — Posted on 2025-05-07
4442 Endothelial AGO1 Drives Vascular Inflammation and Atherosclerosis via a Non-Canonical Nuclear Mechanism
Liu, X.; Yuan, D.; Luo, Y.; Tang, X.; Tapia, A.; Malhi, N. K.; Chadha, R. S.; Tiwari, S.; Swiderski, P.; Wang, K.-C.; Kortylewski, M.; Pardi, N.; Wei, L.; Huang, W.; Chen, Z. B.
10.1101/2025.05.01.651783 — pathology — Posted on 2025-05-07
4445 A Gentle Introduction to Spatial Transcriptomic Analysis with 10X Visium Data
Gillespie, J.; Xie, J.; Jung, K. J.; Hardiman, G.; Pietrzak, M.; Chung, D.
10.1101/2025.05.01.651786 — bioinformatics — Posted on 2025-05-07
4446 Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain
Kong, D.; He, H.; Lechner, J.; Yang, J.; Zhang, A.; li, L.; Mathur, R.; Darland, D.; Takaku, M.; Lu, L.; Peng, J.; Yang, K.; Wang, X.
10.1101/2025.05.01.651759 — bioinformatics — Posted on 2025-05-07
4448 Microglia modulate concussion biomarkers and cognitive recovery in male mice
Anderson, E. D.; Augustin, D.; Georges, A. P.; Kim, T.; Issadore, D. A.; Meaney, D. F.
10.1101/2025.05.01.651070 — bioengineering — Posted on 2025-05-07
4451 Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish
Chen, Z. Z.; Narayanan, S. N.; Stagliano, L. M.; Huynh, P. Q.; Sundaram, S.; Mackey, E. J.; Miller, C. T.; Square, T. A.
10.1101/2025.05.01.651241 — developmental biology — Posted on 2025-05-07
4452 Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis
Shin, A.; Jensen, N.; Butt, E.; An, J.; Pham-Howard, D.; Galambos, L.; Mathieson, K.; Kamins, T.; Palanker, D.
10.1101/2025.05.01.651774 — neuroscience — Posted on 2025-05-07
4458 Pearling Drives Mitochondrial DNA Nucleoid Distribution
Landoni, J. C.; Lycas, M. D.; Macuada, J.; Stepp, W.; Jaccard, R.; Obara, C. J.; Moore, A. S.; Hoffman, D.; Lippincott-Schwartz, J.; Marshall, W.; Sturm, G.; Manley, S.
10.1101/2024.12.21.629917 — cell biology — Posted on 2025-05-07
4459 Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips
Stejskalova, A.; Calderon, K.; Chou, D. B.; Gulati, A.; Feitor, J. F.; Izadifar, Z.; Gutzeit, O.; Bouchibti, Y.; Chen, S.; Plebani, R.; Cotton, J.; Hughes, J. G.; Ferrante, T.; Budnik, B.; Goyal, G.; Junaid, A.; Lebrilla, C. B.; Ingber, D. E.
10.1101/2025.05.01.651107 — bioengineering — Posted on 2025-05-07
4463 Mating Type Gene Divergence is Associated with Life Cycle Differentiation in Scots Pine Blister Rust
Gomez-Zapata, P. A.; Tellgren-Roth, C.; Samils, B.; Stenlid, J.; Kaitera, J.; Brandstrom Durling, M.; Seidl, M. F.; Olson, A.
10.1101/2025.05.02.651906 — evolutionary biology — Posted on 2025-05-07
4464 Alternative reproductive strategies explain asymmetric reinforcement of reproductive isolation in two Ischnura damselfly species
Ordaz-Morales, J. E.; Juarez-Jimenez, A. L.; Stand-Perez, M.; Arce-Valdes, L. R.; Ballen-Guapacha, A. V.; Chavez-Rios, J. R.; Cordero-Rivera, A.; Sanchez-Guillen, R. A.
10.1101/2025.05.04.652146 — evolutionary biology — Posted on 2025-05-07
4466 Macrophage Migration Inhibitory Factor Suppresses Natural Killer Cell Response and Promotes Hypoimmunogenic Stem Cell Engraftment Following Spinal Cord Injury
Li, S.; Zheng, Y.; Xue, H.; Zhang, H.; Wu, J.; Chen, X.; Perez Bouza, M.; Yi, S.; Zhou, H.; Xia, X.; Zeng, X.; Cao, Q. L.; Liu, Y.
10.1101/2025.05.06.652516 — cell biology — Posted on 2025-05-07
4467 A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes
Watanabe, Y. V.; Sussman, J. H.; Anami, T.; Hattori, M.; Yamane, S.; Nishikawa, M.; Sakai, Y.; Katsuda, T.
10.1101/2025.05.07.652591 — cell biology — Posted on 2025-05-07
4468 Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 foci
Wu, C.; Manjarrez-Gonzalez, J. C.; Choudhury, M. S.; Shamkhi, N.; Ding, S.; Nair, V. M.; Draviam, V. M.
10.1101/2025.05.07.652606 — cell biology — Posted on 2025-05-07
4469 Phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages
Cheng, H. Y.; Chu, J.; Limjunyawong, N.; Chen, J.; Ye, Y.; Chen, K. H.; Koylass, N.; Sun, S.; Dong, X.; Qiu, Z.
10.1101/2025.02.27.640612 — immunology — Posted on 2025-05-07
4474 Discover the Maze-like Pathway for Glabridin Biosynthesis
Zhang, Z.; Li, W.; Meng, F.; Jin, Y.; Sun, W.; Kuang, Q.; Ren, S.; Liu, W.; Zhang, L.; Qin, L.; Lv, B.; Jia, H.; Li, C.
10.1101/2025.05.06.652391 — synthetic biology — Posted on 2025-05-07
4475 Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves
Fujii, Y.; Taira, S.; Shinoda, K.; Yamato, Y.; Sakata, K.; Muta, O.; Osada, Y.; Ono, A.; Matsushita, T.; Azumi, M.; Shikano, H.; Abe, K.; Calabrese, V.; Osakabe, N.
10.1101/2025.05.06.652378 — synthetic biology — Posted on 2025-05-07
4477 A synthetic biology toolkit for interrogating plasmid-dependent methylotrophy and enhancing methanol-based biosynthesis of Bacillus methanolicus
Liu, P.; Yuan, Q.; Yang, X.; Wang, Q.; Chang, T.; Bi, Y.; Wu, P.; Zhang, T.; Yang, J.; Guo, S.; Xue, C.; Zheng, Z.; Xin, B.; Ma, H.; Wang, Y.
10.1101/2025.05.06.652373 — synthetic biology — Posted on 2025-05-07
4481 Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy
Zamat, A.; Kim, C.; Sridhar, S.; Fabrega, S.; Sen, R.; Campbell, N.; Oliver, S. A.; Zha, Z.; Thiveaud, C.; Kulaksizoglu, E.; Brienen, M.; Okada, H.; Woodworth, G.; Arvanitis, C.; Kwong, G. A.
10.1101/2025.04.23.650339 — bioengineering — Posted on 2025-05-07
4482 A Preclinical Alcohol BioBank: Samples from Behaviorally Characterized HS Rats for AUD Research
Doyle, M. R.; Campo, P.; Dirik, S.; Balaguer, M.; Martinez, A. R.; Kallupi, M.; de Guglielmo, G.
10.1101/2025.04.30.651600 — animal behavior and cognition — Posted on 2025-05-07
4483 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)
Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.
10.1101/2024.12.06.627158 — genomics — Posted on 2025-05-07
4484 Range-wide responses to an extreme heat event in Mimulus cardinalis
Albano, L. J.; Bingham, R. A.; Correa, S.; Laufenberg, C. G.; Payst, C.; Muir, C. D.; Sheth, S. N.
10.1101/2025.05.01.651703 — evolutionary biology — Posted on 2025-05-07
4491 PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression
Druker, J.; Jiang, H.; Shakir, D.; Child, F.; Alvarez, V.; Platani, M.; Corno, A.; Alabert, C.; Saurin, A. T.; Swedlow, J. R.; Rocha, S.; Lamond, A. I.
10.1101/2025.05.06.652400 — cell biology — Posted on 2025-05-07
4494 Class I myosins direct circumferential F-actin flows to define cell chirality
Yamaguchi, A.; Sasamura, T.; Haraguchi, T.; Yoshimura, K.; Taniguchi, H.; Kurisu, D.; Akano, Y.; Higashi, T.; Sato, Y.; Neugebauer, F. L.; Inaki, M.; Inoue, Y.; Akiyama, M.; Ito, K.; Matsuno, K.
10.1101/2025.05.06.648335 — cell biology — Posted on 2025-05-07
4496 Hidden Diversity in Enterococcus faecalis Revealed by CRISPR2 Screening: Eco-evolutionary Insights into a Novel Subspecies
Leite, V.; Faria, A. R.; Guerra, C.; Souza, S. S. R.; Freitas, A. A. R.; Morais, J.; Merquior, V. L. C.; Planet, P. J.; Teixeira, L. M.
10.1101/2025.05.05.652174 — microbiology — Posted on 2025-05-07
4499 Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy
Zborowsky, S.; Seurat, J.; Balacheff, Q.; Ecomard, S.; Mulet, C.; Minh, C. N. N.; Titecat, M.; Evrard, E.; Rodriguez-Gonzalez, R. A.; Marchi, J.; Weitz, J. S.; Debarbieux, L.
10.1101/2024.01.16.575879 — microbiology — Posted on 2025-05-07
4500 Endospore Appendages Enhance Bacillus cereus Spore Adhesion to Industrial Surfaces, Modulated by Physicochemical Factors
Albertsdottir Jonsmoen, U. L.; Aspholm, M. E.; Malyshev, D.; Allred, J. A.; Segervald, J.; Andersson, M.
10.1101/2025.05.06.652425 — microbiology — Posted on 2025-05-07
4502 Capturing individual variation in children's oscillatory brain activity during nREM sleep
Heikkinen, V.; Merz, S.; Salmelin, R.; Vanhatalo, S.; Lauronen, L.; Liljestrom, M.; Renvall, H.
10.1101/2025.05.02.651817 — neuroscience — Posted on 2025-05-07
4503 Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease
Libera, J. L.; Hu, J.; Nguyen, T.-A.; Wang, Z.; van der Spek, S. J. F.; Schult, K.; Dorrian, L.; Majka, J.; Tobunluepop, K.; Puri, S.; Kynshov, A.; Kanaan, N. M.; Nelson, P. T.; Meyer, K.; Hou, L.; Zhang, X.; Wolozin, B.
10.1101/2025.05.02.651974 — neuroscience — Posted on 2025-05-07
4506 Rhythms of Early Life: Gut Microbiota Rhythmicity and Circadian Maturation in infants
Muehlematter, C.; Nielsen, D. S.; Castro-Mejia, J.; Walser, J.-C.; Schoch, S.; Kurth, S.
10.1101/2025.01.06.631487 — physiology — Posted on 2025-05-07
4509 Accurate and Reproducible Whole-Genome Genotyping for Bacterial Genomic Surveillance with Nanopore Sequencing Data
Prior, K.; Becker, K.; Brandt, C.; Cabal Rosel, A.; Dabernig-Heinz, J.; Kohler, C.; Lohde, M.; Ruppitsch, W.; Schuler, F.; Wagner, G. E.; Mellmann, A.
10.1101/2025.02.24.639834 — bioinformatics — Posted on 2025-05-07
4511 Cross-species analysis of experimental PH at single cell resolution reveals prominent contributions Ednrb+ EC and Dhcr24+ macrophage populations
Li, B.; Xing, Y.; Zhou, Y.; Xiao, X.; Shu, T.; Song, X.; Zhao, H.; Wang, X.-J.; Pang, J.; Yang, P.; Wang, J.; Yu, P. B.; Wang, C.
10.1101/2025.04.30.651587 — bioinformatics — Posted on 2025-05-07
4513 Mechanisms Underlying Allosteric Modulation of Antiseizure Medication Binding to Synaptic Vesicle Protein 2A (SV2A)
Mittal, A.; Martin, M. F.; Provins, L.; Hall, A.; Ledecq, M.; Wolff, C.; Gillard, M.; Horanyi, P. S.; Coleman, J. A.
10.1101/2025.05.05.652227 — biochemistry — Posted on 2025-05-07
4514 Red deer individual landscapes of fear in response to human recreation.
Boehme, B.; Peters, A.; Mitterwallner, V.; Sommer, F.; Heurich, M.; Hertel, A. G.
10.1101/2024.06.20.599860 — animal behavior and cognition — Posted on 2025-05-07
4518 Molecular basis for the regulation of retroviral nucleosomal integration by chromatin compaction
Lapaillerie, D.; Zgadzayy, Y.; Martins, F. G.; Bertinetti, C.; Autin, M.; Batisse, J.; Tumiotto, C.; Paul, L.; Ruff, M.; Sousa, S.; Parissi, V.
10.1101/2025.05.05.652197 — microbiology — Posted on 2025-05-07
4521 Phase-precession-like Effect in the Anterior Insula Cortex during Reward Expectancy
Yang, L.; Lehongre, K.; Ye, H.; Yu, X.; Navarro, V.; Cheng, S.; Axmacher, N.; Wang, S.; Zhang, H.
10.1101/2023.09.19.558205 — neuroscience — Posted on 2025-05-07
4522 FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy
Menon, S.; Gracilla, D.; Breese, M. R.; Lin, Y. P.; Dela Cruz, F. S.; Feinberg, T.; De Stanchina, E.; Galic, A.-F.; Allegakoen, H.; perati, s.; Wen, N.; Heslin, A.; Horlbeck, M.; Weissman, J. S.; Sweet-Cordero, A.; Bivona, T.; Tulpule, A.
10.1101/2023.04.30.538578 — cancer biology — Posted on 2025-05-07
4523 The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging
Li, H.-F.; Dong, B.; Peng, Y.-Y.; Luo, H.-Y.; Ou, X.-L.; Ren, Z.-L.; Park, Y.; Wang, J.-J.; Jiang, H.-B.
10.1101/2024.07.30.605941 — ecology — Posted on 2025-05-07
4525 BRG1 targeting overcomes ABCC-based multidrug resistance induced by paclitaxel
Gronkowska, K.; Michlewska, S.; Ploszaj, T.; Strachowska, M.; Stepien, A.; Borowiec, M.; Bednarek, A.; Robaszkiewicz, A.
10.1101/2025.05.01.651609 — cancer biology — Posted on 2025-05-07
4527 An automated software-assisted approach for exploring metabolic susceptibility and degradation products in macromolecules using High-Resolution Mass Spectrometry
Cifuentes Lopez, P.; Zamora, I.; Radchenko, T.; Fontaine, F.; Garriga, A.; Moretonni, L.; Kammersgaard Christensen, J.; Helleberg, H.; A. Becker, B.
10.1101/2025.05.01.651614 — bioinformatics — Posted on 2025-05-07
4528 Democratizing Organ-on-Chip Technologies with a Modular, Reusable, and Perfusion-Ready Microphysiological System
Minahan, D. J.; Nelson, K. M.; Ribeiro, F.; Ferrick, B. J.; Zurzolo, A. M.; Byers, K.; Gleghorn, J. P.
10.1101/2025.04.30.651503 — bioengineering — Posted on 2025-05-07
4529 3D Printed Nerve Guidance Conduit for Biologics-Free Nerve Regeneration and Vascular Integration
Schimelman, J.; Berry, D. B.; Johnson, S.; Shi, R.; Brown, S.; Nguyen, Q. T.; Chen, S.
10.1101/2025.04.30.651603 — bioengineering — Posted on 2025-05-07
4533 Cytohesin-2 is essential for the survival of mice and regulates Golgi volume and function
Kuesters, C.; Jux, B.; Shakeri, F.; Kallabis, S.; Meissner, F.; Prof. Kolanus, W.
10.1101/2025.05.05.651226 — cell biology — Posted on 2025-05-07
4535 Cover crop root channels promote bacterial adaptation to drought in the maize rhizosphere
Ghosh, D.; Shi, Y.; Zimmermann, I. M.; Holzhauser, K.; Bergen, M. v.; Kaster, A.-K.; Spielvogel, S.; Dippold, M. A.; Mueller, J. A.; Jehmlich, N.
10.1101/2025.05.05.651044 — microbiology — Posted on 2025-05-07
4536 Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cells dysfunction in human cancer
Ward, C. J.; Chakraborty, S.; Shaji, S. K.; Veiga-Villauriz, C.; Zhao, Q.; Chen, X.; Mahata, B.
10.1101/2025.04.30.651472 — immunology — Posted on 2025-05-07
4537 Cellular and Regional Vulnerability Shapes the Molecular Landscape of Psychosis in Alzheimers Disease
Victor, M. B.; Sun, N.; Galani, K.; Leary, N.; Tanigawa, Y.; Scannail, A. N.; Ho, L.-L.; Prosper, S.; Liu, L.; Kofler, J. K.; Sweet, R.; Tsai, L.-H.; Kellis, M.
10.1101/2025.04.30.651435 — neuroscience — Posted on 2025-05-07
4542 Sequencing and functional analysis of Sphingobium yanoikuyae A-TP genome reveals genes for utilization of limonene, α-pinene, and citronellol
Jankovic, N.; Marques de Castro, G.; Quintanilha Torres, A. L.; Chelala Moreira, R.; Uliano-Silva, M.; Souza da Conceicao, C.; Lima Coelho, V.; Alves Americo, J.; Lemos Bicas, J.; de Freitas Rebelo, M.
10.1101/2025.04.30.651573 — genomics — Posted on 2025-05-07
4543 Adapter dilution and input optimisation for Qiagen QIAseq miRNA Library kit
Hasby, F.; Bachmann, J. A.; Wang, C.; Contreras-Lopez, O.; Mezger, A.
10.1101/2025.04.30.651388 — genomics — Posted on 2025-05-07
4544 Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes
Sadri, G.; Nadakal, S. T.; Lauer, W. A.; Kos, J.; Singh, P.; Elliott, E. M.; Kaiser, C.; Ford, E. E.; Richardson, N.; Hudson, E.; Linden, N.; Danesh, A.; Powell, J.; Warburton, P.; Soto, J.; Emery, M.; Deikus, G.; Lee, G. Q.; Lamers, S.; Reynolds, S. J.; Galiwango, R. M.; Prodger, J. L.; Tomusange, S.; Kityamuweesi, T.; Han, T.; Jones, R. B.; Tobian, A. A. R.; Engelman, A. N.; Sebra, R.; Morgello, S.; Redd, A. D.; Sachs, D.; Rouchka, E.; Smith, M. L.
10.1101/2025.05.01.651657 — genomics — Posted on 2025-05-07
4545 Emergence Risks from Within? Metagenomic Analysis of Mosquito Viromes from Two Zoos Reveals Mosquito-associated Orthobunyaviruses in the UK
Pilgrim, J.; Seechurn, N.; Cunningham-Oakes, E.; Dobbs, P.; Lopez, J.; Kohl, A.; Hughes, G. L.; Blagrove, M. S.; Baylis, M.; Darby, A. C.
10.1101/2025.05.01.651672 — genomics — Posted on 2025-05-07
4549 CRISPR-Cas9 HDR Optimization: RAD52, Denatured and 5'-Modified DNA Templates in Knock-In Mice Generation
Skryabin, B. V.; Braun, D. A.; Kaiser, H.; Gubar, L.; Seeger, B.; Khanam, T.; Stegemann, A.; Pavenstädt, H.; Rozhdestvensky, T. S.
10.1101/2025.05.05.652162 — molecular biology — Posted on 2025-05-07
4550 Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models
Goddard, P.; Tzelos, T.; Colon, B. L.; Bartley, P.; Robinson, L.; Lemgruber, L.; Tinti, M.; Hall, G. M.; Stevens, S.; Gibbard, L.; Bernard, R.; Tytler, G.; Smith, D.; Katzer, F.; Pawlowic, M. C.
10.1101/2025.05.05.652177 — microbiology — Posted on 2025-05-07
4552 Revisiting atypical language lateralization in dyslexia
Verhelst, H.; Karlsson, E. M.; Gerrits, R.; Vingerhoets, G.
10.1101/2025.05.06.652381 — neuroscience — Posted on 2025-05-07
4555 Loss of age-associated increase in mA-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease
Libera, J. L.; Hu, J.; Nguyen, T.-A.; Wang, Z.; van der Spek, S. J. F.; Schult, K.; Dorrian, L.; Majka, J.; Tobunluepop, K.; Puri, S.; Kynshov, A.; Kanaan, N. M.; Nelson, P. T.; Meyer, K.; Hou, L.; Zhang, X.; Wolozin, B.
10.1101/2025.05.02.651974 — neuroscience — Posted on 2025-05-07
4558 The dynamic transcriptome of Plasmodium malariae in the mosquito
Ruiz, J. L.; Diaz-Terenti, B.; Lefevre, T. D.; Yerbanga, S. R.; Otto, T. D.; Gomez-Diaz, E.
10.1101/2025.05.05.652270 — microbiology — Posted on 2025-05-07
4559 Molecular basis for the regulation of retroviral nucleosomal integration by chromatin compaction
Zgadzayy, Y.; Martins, F. G.; Bertinetti, C.; Autin, M.; Batisse, J.; Tumiotto, C.; Paul, L.; Ruff, M.; Sousa, S.; Parissi, V.
10.1101/2025.05.05.652197 — microbiology — Posted on 2025-05-07
4562 Diverse and Flexible Strategies Enable Successful Cooperation in Marmoset Dyads
Meisner, O. C.; Shi, W.; Nair, A.; Nandy, G.; Jadi, M. P.; Nandy, A. S.; Chang, S. W. C.
10.1101/2025.05.06.652115 — neuroscience — Posted on 2025-05-07
4563 EGFR activation correlates with intracranial pressure and outcome in a mixed intracranial bleeding porcine model
Zhao, Z.; Hoffmann, A.; Groeger, M.; Kress, S.; Muenz, F.; Sun, F.; Merz, T.; Sheer, M.; Calzia, E.; Oezkan, B.; Radermacher, P.; Roselli, F.; Kapapa, T.; Pagliarini, M.
10.1101/2025.05.02.651431 — neuroscience — Posted on 2025-05-07
4564 Synaptic vesicles that store monoamines and glutamate differ in protein composition.
Asmerian, H.; Diaz, A. J.; Xu, H.; Oses-Prieto, J. A.; Alberts, J.; Sanetra, A. M.; Gnanabharathi, B.; Carr, N.; Burlingame, A. L.; Edwards, R. H.; Silm, K.
10.1101/2025.05.06.651945 — neuroscience — Posted on 2025-05-07
4566 HADDOCK3: A modular and versatile platform for integrative modelling of biomolecular complexes
Giulini, M.; Reys, V.; Teixeira, J. M. C.; Jimenez-Garcia, B.; Honorato, R. V.; Kravchenko, A.; Xu, X.; Versini, R.; Engel, A.; Verhoeven, S.; Bonvin, A. M. J. J.
10.1101/2025.04.30.651432 — bioinformatics — Posted on 2025-05-07
4571 Time-course Transcriptomics Reveals the Impact of Treponema pallidum on Microvascular Endothelial Cell Function and Phenotype
Waugh, S.; Goodyear, M. C.; Gomez, A.; Ranasinghe, A.; Lithgow, K. V.; Falsafi, R.; Hancock, R. E. W.; Lee, A. H.; Cameron, C. E.
10.1101/2025.05.04.651946 — molecular biology — Posted on 2025-05-06
4578 Drug screen reveals new potent host-targeted antivirals against Mpox virus
Arumugaswami, V.; Damoiseaux, R.; Kumar, A.; JEYACHANDRAN, A. V.; Zaiss, A. K.; Chakravarty, N.; Singh, S.; Delgado, Y.; Paravastu, R.; Satheeshkumar, N.; Gerald, E.; Jeysankar, A.; Thomas, J.; Fuller, L.; Lee, N.; Taylor, C.; Joshi, S.; Parcells, M. S.; French, S. W.; Date, A.; Bouhaddou, M.; Garcia, G.
10.1101/2025.05.02.651913 — microbiology — Posted on 2025-05-07
4580 Structural Interactions of Ankyrin B with NrCAM and β2 Spectrin
Chirasani, V. R.; Haberman, V. A.; Oldre, E. F.; Webb, B. D.; Pereira, E. B.; Yang, W.; Maness, P. F.
10.1101/2025.04.30.651523 — neuroscience — Posted on 2025-05-06
4582 Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD
He, J.; Chen, B.; Wang, X.; Yang, R.; Deng, C.; Zhu, X.; Wang, K.; Wang, L.; Lu, X.; Peng, C.; Li, C.; Shan, Z.
10.1101/2025.05.06.652369 — molecular biology — Posted on 2025-05-06
4585 Computational modeling of necrosis in neural organoids
Pantula, A.; Zhou, B.; Morales Pantoja, I. E.; Fedotova, A.; George, D.; Alam El Din, D.-M.; Lysinger, A.; Smirnova, L.; Gracias, D. H.
10.1101/2025.04.30.651571 — bioengineering — Posted on 2025-05-06
4586 Structural insight into the transcription activation mechanism of the phage Mor/C family activators
Shi, J.; Ye, Z.; Huang, Y.; Xu, L.; Xu, S.; Xie, L.; Chen, W.; Wang, L.; Feng, Z.; Song, Q.; Wang, S.; Feng, Y.; Lin, W.
10.1101/2025.05.02.651988 — biochemistry — Posted on 2025-05-06
4587 Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus
Wee, D.; Pandey, M.; Chen, Y.; Lorenzini, P. A.; Chow, E. W.; Wang, Y.; Singhal, A.; Oehlers, S. H.
10.1101/2025.05.05.652332 — microbiology — Posted on 2025-05-06
4589 The small membrane protein YohP induces membrane depolarization and ppGpp accumulation in Escherichia coli.
Natriashvili, A.; Mohammadsadeghi, N.; Milanov, M.; Smudde, E.; Prucker, I.; Jessen, H.; Carabadjac, I.; Heerklotz, H.; Franco, P. H. C.; Langer, J.; Koch, H.-G.
10.1101/2025.05.06.652344 — microbiology — Posted on 2025-05-06
4591 Tyrosine availability shapes Staphylococcus aureus nasal colonization and interactions with commensal communities
Camus, L.; Franz, J.; Gerlach, D.; Lange, A.; Power, J. J.; Navarro-Diaz, M.; Rapp, J.; Otto, M.; Klages, L. J.; Starostin, V.; Mössner, J.; Bilici, K.; Ham, S.; Kalinowski, J.; Angenent, L. T.; Link, H.; Heilbronner, S.
10.1101/2025.05.06.651429 — microbiology — Posted on 2025-05-06
4594 Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies
Wobma, H.; Alvarez Calderon, F.; Dong, J.; Omdahl, K.; Rui, X.; Rojas Palato, E. J.; Bermea, R. S.; Albanese, A.; Wachter, F.; Winschel, M.; Michaelis, K. A.; Cagnin, L.; Tkachev, V.; Prockop, S. E.; Nigrovic, P. A.; Blazar, B. R.; Gerdemann, U.; Kean, L. S.
10.1101/2025.04.30.651441 — immunology — Posted on 2025-05-06
4599 Modeling and Prediction of Body Segment Inertial Properties of Sheep from Tomographic Imaging
Henry, A.; Benner, C. M.; Covan, B.; Helin, A.; Gaddy, D.; Suva, L.; Robbins, A. B.
10.1101/2025.04.30.651518 — bioengineering — Posted on 2025-05-06
4600 3D osteocyte networks under Pulsatile Unidirectional Fluid Flow Stimuli (PUFFS)
Merife, A.-B.; Poudel, A.; Polshchikova, A.; Geffert, Z. J.; Horton, J.; Akash, M. M. H.; Pandey, A.; Basu, S.; Fougnier, D.; Soman, P.
10.1101/2025.04.30.651549 — bioengineering — Posted on 2025-05-06
4601 ArchLips: A comprehensive in silico database for high-throughput identification of archaeal lipids
Zheng, F.; Yao, W.; He, W.; Zhang, W.; Chen, Y.; Chen, H.; Zeng, Z.; Liu, X.-L.; Ding, S.; Zheng, Y.; Huang, L.; Zhu, Y.; Zhang, C.
10.1101/2025.05.05.652033 — biochemistry — Posted on 2025-05-06
4605 A Cluster of Acidic Residues in the Cytoplasmic Domain of SARS-CoV-2 Spike is Required for Virion-Incorporation and Infectivity
Stoneham, C. A.; Singh, R.; De Leon, A.; Tafelmeyer, P.; Acosta, F.; Fuori, A.; Anderson, M.; Ramirez, P. W.; Schwartzer-Sperber, H. S.; Pillai, S. K.; Lewinski, M. K.; Guatelli, J.
10.1101/2025.05.04.652125 — molecular biology — Posted on 2025-05-06
4608 Defence systems drive accessory genome interactions in Pseudomonas aeruginosa.
Chong, C. E.; Weimann, A.; Agapov, A.; Fothergill, J. L.; Brockhurst, M. A.; Parkhill, J.; Floto, R. A.; Szczelkun, M.; Westra, E. R.; Consortium, M.-D.; Baker, K. S.
10.1101/2025.05.06.652404 — microbiology — Posted on 2025-05-06
4610 Tracking polyhydroxyalkanoate biosynthesis in thermophilic microorganisms
Schroyen, B.; Moanis, R.; Geeraert, H.; Van den Brande, N.; Hennecke, U.; Obruca, S.; Buchtikova, I.; Sedlar, K.; Sedlacek, P.; Peeters, E.
10.1101/2025.05.06.652502 — microbiology — Posted on 2025-05-06
4612 A prophage-encoded sRNA limits lytic phage infection of adherent-invasive E. coli
Brzozowski, R. S.; Schmidt, A. K.; Pershing, N. L.; Dankwardt, A.; Faith, D. R.; Joyce, A. C.; Maciver, A.; Henriques, W. S.; Andersen, S. E.; Wiedenheft, B.; Casjens, S.; Duerkop, B. A.; Round, J. L.; Secor, P. R.
10.1101/2025.05.06.652453 — microbiology — Posted on 2025-05-06
4614 Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector
Pennance, T.; Spaan, J.; Xiong, Y.; Churan, A.; Loczi-Storm, A.; Ward, D.; Islam, T.; Calcote, A.; Fuller, E.; Marsonette, B.; Odiere, M.; Steinauer, M.
10.1101/2025.05.06.651976 — microbiology — Posted on 2025-05-06
4615 The Gfr uptake system provides a context-dependent fitness advantage to Salmonella Typhimurium SL1344 during the initial gut colonization phase
Fuchs, L.; Dieterich, C. L.; Ros, E. M.; Keller, P.; Laganenka, L.; Schubert, C.; Vorholt, J. A.; Piel, J.; Hardt, W.-D.; Nguyen, B. D.
10.1101/2025.05.06.652348 — microbiology — Posted on 2025-05-06
4618 Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential
Perfilyev, A.; Shen, A.; Hooton, S.; Zahran, S. A.; Winther-Have, C. S.; Kalatzis, P.; Wilkinson, R. C.; Thanki, A. M.; Petersen, B.; Liu, Z.; Zhang, Q.; Liu, Y.; Ibarra-Chavez, R.; Gigante, A.; Lv, Q.; Atterbury, R.; Millard, A. D.; Clokie, M. R. J.; Sicheritz-Ponten, T.
10.1101/2025.05.06.652010 — microbiology — Posted on 2025-05-06
4623 Boltz-1: Democratizing Biomolecular Interaction Modeling
Wohlwend, J.; Corso, G.; Passaro, S.; Getz, N.; Reveiz, M.; Leidal, K.; Swiderski, W.; Atkinson, L.; Portnoi, T.; Chinn, I.; Silterra, J.; Jaakkola, T.; Barzilay, R.
10.1101/2024.11.19.624167 — biophysics — Posted on 2025-05-06
4624 The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci
Weldy, C. S.; Kundu, S.; Monteiro, J. P.; Gu, W.; Pedroza, A. J.; Dalal, A. R.; Worssam, M. D.; Li, D. Y.; Palmisano, B. T.; Zhao, Q.; Sharma, D.; Nguyen, T.; Kundu, R. K.; Fischbein, M. P.; Engreitz, J.; Kundaje, A. B.; Cheng, P. P.; Quertermous, T.
10.1101/2022.05.18.492517 — genomics — Posted on 2025-05-06
4626 Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease
Libera, J. L.; Hu, J.; Nguyen, T.-A.; Wang, Z.; van der Spek, S. J. F.; Schult, K.; Dorrian, L.; Majka, J.; Tobunluepop, K.; Puri, S.; Kynshov, A.; Kanaan, N. M.; Nelson, P. T.; Meyer, K.; Hou, L.; Zhang, X.; Wolozin, B.
10.1101/2025.05.02.651974 — neuroscience — Posted on 2025-05-06
4632 Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles
Busch, G. T.; Boe, R. H.; Li, J.; Gruener, R. F.; Arnett, M. J.; Ravindran, P. T.; Herlyn, M.; Huang, R. S.; Raj, A.
10.1101/2025.04.25.650475 — systems biology — Posted on 2025-05-06
4634 scBaseCount: An AI agent-curated, uniformly processed, and continually expanding single cell data repository
Youngblut, N. D.; Carpenter, C.; Prashar, J.; Ricci-Tam, C.; Ilango, R.; Teyssier, N.; Konermann, S.; Hsu, P.; Dobin, A.; Burke, D. P.; Goodarzi, H.; Roohani, Y. H.
10.1101/2025.02.27.640494 — bioinformatics — Posted on 2025-05-06
4635 FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research
Al Manir, S.; Levinson, M. A.; Niestroy, J.; Churas, C.; Parker, J. A.; Clark, T.
10.1101/2024.12.23.629818 — bioinformatics — Posted on 2025-05-06
4637 Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation
Hochmair, J.; van den Oetelaar, M. C. M.; Ravatt, L.; Diez, L.; Lemmens, L. J. M.; Ponce Lina, R.; Sankar, R.; Franck, M. W.; Nolte, G.; Semenova, E.; Mohapatra, S.; Ottmann, C. O.; Brunsveld, L.; Wegmann, S.
10.1101/2024.03.15.585148 — biochemistry — Posted on 2025-05-06
4638 Identifying in vivo genetic dependencies of melanocyte and melanoma development
Perlee, S.; Ma, Y.; Hunter, M. V.; Swanson, J. B.; Cruz, N. M.; Ming, Z.; Xia, J.; Lionnet, T.; McGrail, M.; White, R.
10.1101/2024.03.22.586101 — genetics — Posted on 2025-05-06
4640 Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics
Peshkin, L.; Daldello, E. M.; Van Itallie, E. S.; Sonnett, M.; Kreuzer, J.; Haas, W.; Kirschner, M. W.; Jessus, C.
10.1101/2024.07.26.605364 — developmental biology — Posted on 2025-05-06
4642 Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety
Mourra, D.; Murphy, C. E.; Hourany, E.; Centeno, K.; Gnazzo, F.; Beeler, J. A.
10.1101/2025.04.29.651295 — neuroscience — Posted on 2025-05-06
4643 Regional deficits in endogenous regeneration of mouse olfactory sensory neuron axons
Kunkhyen, T.; Curtis, K. A.; Deakin, T. P.; Huang, J. S.; Gregory, J. D.; Cheetham, C. E. J.
10.1101/2024.10.06.616907 — neuroscience — Posted on 2025-05-06
4644 Cross-order detection of bacteriophage transduction in communities using ribosomal RNA barcoding
LaTurner, Z. W.; Dysart, M. J.; Schwartz, S. K.; Zeng, E.; Chappell, J.; Silberg, J. J.; Stadler, L. B.
10.1101/2025.05.03.652062 — synthetic biology — Posted on 2025-05-06
4646 Ionizable networks mediate pH-dependent allostery in SH2 signaling proteins
Van Dyck, P. K.; Piszkin, L.; Gorski, E. A.; Tartarella Nascimento, E.; Abebe, J. A.; Hoffmann, L. M.; Peng, J. W.; White, K. A.
10.1101/2024.08.21.608875 — biochemistry — Posted on 2025-05-06
4650 P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability
Zaatra, W.; Philippos, G.; Smirnov, P.; Cochavi, S. M.; Otonicar, J.; Chan, M.; Harel, M.; Devens, F.; Goldberg, T.; Eliassaf, A.; Grimes, K.; Irony-Tur Sinai, M.; Sigismondo, G.; Geiger, T.; Korbel, J.; Krijgsveld, J.; Shalev, O.; Kerem, B.; Ernst, A.
10.1101/2025.04.17.649416 — cancer biology — Posted on 2025-05-06
4653 Density-dependent network structuring within and across wild animal systems
Albery, G. F.; Becker, D. J.; Firth, J. A.; De Moor, D.; Ravindran, S.; Silk, M.; Sweeny, A. R.; Wal, E. V.; Webber, Q.; Allen, B.; Babayan, S. A.; Barve, S.; Begon, M.; Birtles, R. J.; Block, T. A.; Block, B. A.; Bradley, J. E.; Budischak, S.; Buesching, C.; Burthe, S. J.; Carlisle, A. B.; Caselle, J. E.; Cattuto, C.; Chaine, A. S.; Chapple, T.; Cheney, B. J.; Clutton-Brock, T.; Collier, M.; Curnick, D. J.; Delahay, R. J.; Farine, D. R.; Fenton, A.; Ferretti, F.; Fielding, H.; Foroughirad, V.; Frere, C.; Gardner, M. G.; Geffen, E.; Godfrey, S. S.; Graham, A. L.; Hammond, P. S.; Henrich, M.; H
10.1101/2024.06.28.601262 — ecology — Posted on 2025-05-06
4654 Stealth replication of SARS-CoV-2 Omicron in the nasal epithelium at physiological temperature
Fonseca, B. F.; Robinot, R.; Michel, V.; Mendez, A.; Lebourgeois, S.; Chive, C.; Jeger-Madiot, R.; Vaid, R.; Bondet, V.; Maloney, E.; Guivel-Benhassine, F.; Schwartz, O.; Duffy, D.; Mondal, T.; Gobaa, S.; Chakrabarti, L. A.
10.1101/2025.05.03.652024 — microbiology — Posted on 2025-05-05
4655 Do Existing COVID-19 Vaccines Need to Be Updated in 2025?
Mellis, I. A.; Wu, M.; Wang, Q.; Bowen, A.; Gherasim, C.; Pierce, V. M.; Shah, J. G.; Purpura, L. J.; Yin, M. T.; Gordon, A.; Guo, Y.; Ho, D. D.
10.1101/2025.05.02.651777 — microbiology — Posted on 2025-05-05
4657 H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves
Souza, C. K.; Santos, J. J. S.; Boggiatto, P.; Sterle, H.; Arruda, B.; Palmer, M. V.; Campos, A.; Liu, J.; Ye, N.; Weissman, D.; Hensley, S. E.; Baker, A. L.
10.1101/2025.05.01.651548 — microbiology — Posted on 2025-05-06
4658 Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis
Chung, J.; Vallurupalli, M.; Noel, S.; Schor, G.; Liu, Y.; Nobrega, C.; Perera, J.; Wrona, E.; Hu, M.; Lin, Y.; Wu, D. w.; Saberi, M.; Scapozza, I.; Cruickshank, A.; Woods, E. C.; Chuong, C. L.; Birocchi, F.; Kammula, A.; Avila, O. I.; Kocak, M.; Doench, J. G.; Procter, D.; Thornton, L.; Brunner, A. M.; Winer, E.; DeAngelo, D. J.; Garcia, J. S.; Stone, R. M.; Jenkins, R. W.; Maus, M. V.; Graubert, T. A.; Yates, K. B.; Golub, T. R.; Manguso, R. T.
10.1101/2025.05.05.652090 — cancer biology — Posted on 2025-05-06
4663 Desmodium Volatiles in "Push-Pull" Cropping Systems and Protection Against the Fall Armyworm, Spodoptera frugiperda
Odermatt, D. M.; Chidawanyika, F.; Mutyambai, D. M.; Schmid, B.; Domeignoz Horta, L. A.; Onjura, C. O.; Tamiru, A.; Schuman, M. C.
10.1101/2024.07.24.604900 — ecology — Posted on 2025-05-06
4664 Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency
Kaper, D.; Radovic, U.; Bergh, P.-O.; Qvist, A.; Henricsson, M.; Boren, J.; Pilon, M.
10.1101/2024.11.08.622646 — cell biology — Posted on 2025-05-06
4665 Disrupted priming within draining lymph nodes drives immune quiescence in gastric cancer
Salehi, S.; Stroobant, E. E.; Lees, H.; Lin, Y.-H.; Shimada, S.; Abate, M.; Zatzman, M. J.; Ceglia, N.; Freeman, S.; Laszkowska, M.; Maron, S. B.; McPherson, A.; Rusk, N.; Havasov, E.; Drebin, H.; Gu, P.; Tang, L. H.; Janjigian, Y. Y.; Soldatov, R.; Chaligne, R.; Shah, S. P.; Strong, V. E.; Vardhana, S. A.
10.1101/2025.05.05.651897 — immunology — Posted on 2025-05-06
4666 Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough
Naqvi, K. F.; Warden, L. L.; van Dijk, J. H. M.; Naik, D. K.; Espinosa-Becarra, F. d. J.; Okolie, I. M.; Verhoeks, V. F. H.; Rahlwes, K. C.; Xavier, C. P.; Codee, J. D. C.; Price, T. J.; Shiloh, M. U.
10.1101/2025.05.01.651726 — neuroscience — Posted on 2025-05-06
4669 Structural basis of PPARγ-mediated transcriptional repression by the covalent inverse agonist FX-909
Laughlin, Z. T.; Arifova, L.; Munoz-Tello, P.; Yu, X.; Dong, J.; Harp, J. M.; Zu, D.; Kamenecka, T. M.; Kojetin, D. J.
10.1101/2025.05.04.651770 — biophysics — Posted on 2025-05-06
4672 Interplay Between Intrinsically Disordered Proteins and Atomically Precise Gold Nanoclusters Modulates their Optical Properties
Rodriguez, S.; Kumanski, S.; Ayed, Z.; Fournet, A.; Bouanchaud, C.; Sagar, A.; Allemand, F.; Resch-Genger, U.; Cortes, J.; Sibille, N.; Chirot, F.; Wegner, K. D.; Antoine, R.; Le Guevel, X.; Bernado, P.
10.1101/2025.05.06.652423 — biochemistry — Posted on 2025-05-06
4673 Antibody response to Aedes aegypti D7L1+2 salivary proteins as marker of aggregate vector exposure and correlate of dengue virus susceptibility
Bahr, L.; Hamins-Puertolas, M.; Buddhari, D.; Petzlova, I.; Oliveira, F.; Thomas, S. J.; Thangamani, S.; Waickman, A.; Anderson, K.
10.1101/2025.05.01.651659 — immunology — Posted on 2025-05-06
4674 H2O2-induced astrocytic collagen triggers neuronal death via fucosylation-dependent glial barrier formation upon ischemic stroke
Lee, J.-H.; Hwang, I.-Y.; Jang, H. J.; Lim, J.; Jung, J.; Kim, M.; Lee, E.; Won, W.; Lee, E. H.; Kim, K. J.; Park, K. D.; Jung, W.; Lee, B.; Ryu, S.; Lee, C. J.
10.1101/2025.05.01.651594 — neuroscience — Posted on 2025-05-06
4676 NMR Spectral Alignment Utilizing a CryoEM Motion Correction Algorithm
Hemme, C.; Warmuth, O.; Wang, S.; Williams, C.; Thome, A.; Mueller, L. J.; Rienstra, C. M.; Grant, T.
10.1101/2025.05.05.652277 — biophysics — Posted on 2025-05-06
4677 Ultra-High Resolution Solid-State NMR for High Molecular Weight Proteins on GHz-Class Spectrometers
Wang, S.; Ravula, T.; Stringer, J. A.; Gor'kov, P.; Warmuth, O.; Williams, C.; Thome, A.; Mueller, L. J.; Rienstra, C. M.
10.1101/2025.05.05.652283 — biophysics — Posted on 2025-05-06
4678 Inferring diffusion, reaction, and exchange parameters from imperfect FRAP
Lorenzetti, E.; Municio-Diaz, C.; MINC, N.; Boudaoud, A.; Fruleux, A.
10.1101/2025.05.06.652329 — biophysics — Posted on 2025-05-06
4679 Top-Down Scoring of Spectral Fitness by Image Analysis for Protein Structure Validation
Harding, B. D.; DeZonia, B.; Garg, R.; Hu, Z.; Delaglio, F.; Grant, T.; Rienstra, C. M.
10.1101/2025.05.05.652267 — biophysics — Posted on 2025-05-06
4680 Simultaneous particle tracking, phase retrieval and point spread function reconstruction
Fazel, M.; Hoseini, R.; Mahmoodi, M.; Xu, L. W. Q.; Saurabh, A.; Kilic, Z.; Antolin, J.; Scrudders, K. L.; Shepherd, D. P.; Low-Nam, S. T.; Huang, F.; Presse, S.
10.1101/2025.05.02.651986 — biophysics — Posted on 2025-05-06
4681 Design and Characterisation of Photoactivatable and Lysine Reactive o-Nitrobenzyl Alcohol-Based Crosslinkers
Cahill, A.; Walko, M.; Fenton, B.; Ganji, S. R.; Herbert, A.; Radford, S.; Kapur, N.; Livingstone, K.; Wright, M.; Calabrese, A. N.
10.1101/2025.05.06.652371 — biophysics — Posted on 2025-05-06
4682 Environment dependent benefits of sociality in Soay sheep
Siracusa, E. R.; Bal, X.; De Moor, D. R.; Albery, G. F.; Beattie, R.; Ravindran, S.; Wiersma, E.; Renwick Wilson, A.; Pemberton, J. M.; Nussey, D.; Silk, M. J.
10.1101/2025.05.04.652099 — animal behavior and cognition — Posted on 2025-05-06
4683 Cellular integration of beneficial de novo emerging proteins via ancient pathways
Houghton, C. J.; Castilho Coelho, N.; Chiang, A.; Hedayati, S.; Parikh, S. B.; Ozbaki-Yagan, N.; Wacholder, A.; Iannotta, J.; Berger, A.; Wohlever, M. L.; Carvunis, A.-R.; O'Donnell, A. F.
10.1101/2024.08.28.610198 — evolutionary biology — Posted on 2025-05-06
4684 Leishmania tarentolae and Leishmania infantum in geckos from Mallorca Island, Spain
Marti-Carreras, J.; Espunyes, J.; Carrera-Faja, L.; Pasetto, C.; Alcover Amengual, M. M.; Chavez-Fisa, S.; Carrasco, M.; Roura, X.; Francino, O.; Ferrer, L.
10.1101/2025.02.06.636881 — microbiology — Posted on 2025-05-06
4685 Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development
Habib, R.; Roark, R. S.; Li, H.; Connell, A. J.; Hogarty, M. P.; Wagh, K.; Wang, S.; Marchitto, L.; Skelly, A. N.; Carey, J. W.; Sowers, K. J.; Ayyanathan, K.; Plante, S. J.; Bibollet-Ruche, F.; Park, Y.; Agostino, C. J.; Singh, A.; Martella, C. L.; Lewis, E.; Lora, J.; Ding, W.; Campion, M. S.; Zhao, C.; Liu, W.; Li, Y.; Li, X.; Liang, B.; Chowdhury, R. R.; Amereh, K.; Van Itallie, E.; Sheng, Z.; Ghosh, A. R.; Bar, K. J.; Williams, W. B.; Wiehe, K.; Saunders, K. O.; Edwards, R. J.; Cain, D. W.; Lewis, M.; Batista, F. D.; Burton, D. R.; Andrabi, R.; Kulp, D. W.; Haynes, B. F.; Korber, B.; Shap
10.1101/2025.05.03.652068 — immunology — Posted on 2025-05-06
4695 MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities
Zhang, W.; Good, Z.; Baertsch, M. A.; Lu, G.; Hickey, J. W.; Hildebrand, R.; Chang, S.; Gentles, A. J.; Sunwoo, J. B.; Le, Q.-T.; Kong, C.; Nolan, G. P.; Plevritis, S. K.
10.1101/2025.04.30.651486 — systems biology — Posted on 2025-05-06
4696 Multiomic clocks to predict phenotypic age in mice
Vera, D.; Griffin, P. T.; Leigh, D.; Kras, J.; Ramos, E.; Bishof, I.; Butler, A.; Chwalek, K.; Vogel, D.; Kane, A. E.; Sinclair, D. A.
10.1101/2025.04.30.651114 — systems biology — Posted on 2025-05-06
4697 The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae
Yen, P.-S.; Verkuijl, S. A.; Capriotti, P.; Del Corsano, G.; Hoermann, A.; Inghilterra, M. G.; Aramburu-Gonzalez, I.; Khan, M. A.; Christophides, G. K.; Vlachou, D.; Windbichler, N.
10.1101/2025.05.02.651860 — synthetic biology — Posted on 2025-05-06
4700 Phylogenetic Analysis and Machine Learning Identify Signatures of Selection and Predict Deleterious Mutations in Common Bean
Cordoba-Novoa, H. A.; Buckler, E. S.; Romay, C.; Berthel, A.; Johnson, L.; Balasubramanian, P.; Hoyos Villegas, V.
10.1101/2025.05.05.652309 — plant biology — Posted on 2025-05-06
4702 Antiviral CD4+ T and myeloid cell responses to influenza vaccines are attenuated in older adults
Oakes, J. M.; Simmons, J. D.; Hager-Nochowicz, C.; Kirk, L.; Eason, J.; Halasa, N. B.; Talbot, H. K.; Bailin, S. S.; Castilho, J. L.; Kalams, S. A.
10.1101/2025.04.30.651528 — immunology — Posted on 2025-05-06
4703 Matrix-M(R) adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
Zarnegar, B.; Carow, B.; Eriksson, J.; Spennare, E.; Öhlund, P.; Akpinar, E.; Bringeland, E.; Osterman, I. L.; Lundqvist, L.; Antti, J.; Handin, N.; Helgesson, P.-H.; Bankefors, J.; Bengtsson, K. L.; Sellin, M. E.; Palm, A.-K.; Stertman, L.; Andersson, C. L.
10.1101/2025.04.30.651498 — immunology — Posted on 2025-05-06
4704 Divergence of root system traits in soybean between breeding and diversity lines
Bogati, S.; Carpenter, J.; Jung, J.; Schafer, S. E.; Danao, J.; Woods, E.; Song, Q.; kantar, M.; Ma, J.; Wang, D. R.
10.1101/2025.05.05.651701 — plant biology — Posted on 2025-05-06
4708 Structural determinants for red-shifted absorption in higher-plants Photosystem I
Capaldi, S.; Guardini, Z.; Montepietra, D.; Pagliuca, V. F.; Amelii, A.; Betti, E.; John, C.; Pedraza-Gonzalez, L.; Cupellini, L.; Mennucci, B.; Bonnet, D. M. V.; Chaves-Sanjuan, A.; Dall'Osto, L.; Bassi, R.
10.1101/2025.05.05.652163 — plant biology — Posted on 2025-05-06
4709 S2-PepAnalyst: A Web Tool for Predicting Plant Small Signalling Peptides
Vomo Donfack, K. L.; Abaach, M.; Luna, A. M.; Ginot, G.; Doblas, V. G.; Morilla, I.
10.1101/2024.08.02.606319 — plant biology — Posted on 2025-05-06
4711 Automated Joint Space Detection Improves Bone Segmentation Accuracy
Kenney, H. M.; Lichau, D.; Blanc, R.; Schnur, L.; Bell, R. D.; Ritchlin, C. T.; Schwarz, E. M.; Awad, H. A.; Wood, R. W.
10.1101/2025.04.30.651481 — pathology — Posted on 2025-05-06
4712 Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast Cancers
Pedroza, D. A.; Yuan, X.; Liu, F.; Chan, H. L.; Zhang, C.; Bowie, W.; Smith, A. J.; Calderon, S. J.; Lieu, N.; Wu, W.; Porter, P.; Sarkar, P.; Zhao, N.; Oehler, C. V.; Peller, O.; Gaber, M. W.; Zhu, Q.; perou, c.; Zhang, X.; Rosen, J.
10.1101/2025.04.30.651522 — cancer biology — Posted on 2025-05-06
4714 SAKPE: A Site Attention Kinetic Parameters Prediction Method for Enzyme Engineering
Qiu, J.-H.; Lin, Z.; Chen, K.-W.; Sun, T.-Y.; Zhang, X.; Yuan, L.; Tian, Y.; Wu, Y.-D.
10.1101/2025.04.30.651216 — bioinformatics — Posted on 2025-05-06
4718 The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity
Pinto, A. J.; Chouquet, A.; Bally, I.; Rossi, V.; Thielens, N. M.; Dumestre-Perard, C.; Kunert, R.; Gaboriaud, C.; Ling, W. L. W.; REISER, J.-B.
10.1101/2024.07.10.602503 — biochemistry — Posted on 2025-05-06
4719 Enzymatic carbon-fluorine bond cleavage by human gut microbes
Probst, S. I.; Felder, F. D.; Poltorak, V.; Mewalal, R.; Blaby, I. K.; Robinson, S. L.
10.1101/2024.07.15.601322 — biochemistry — Posted on 2025-05-06
4721 Integrative Analysis of Single-cell and Bulk RNA Sequencing Reveals Macrophage Heterogeneity in Lyme Arthritis
Zhou, G.; Song, C.; Dong, Y.; Chen, Y.; Luo, Y.; Liu, M.; Zhou, Y.; Yang, Y.; Chen, X.; Liu, X.; Yang, F.; Liang, Z.; Zi, L.; Gao, H.; Cao, Z.; Gao, F.
10.1101/2025.02.14.638349 — genomics — Posted on 2025-05-06
4722 Identification of the role of SEL1L in platelet function through a multi-species genetic investigation
Dahlgren, A. R.; Careddu, F.; Norris, J. W.; Adili, R.; Kropp, E. M.; Li, Q.; Holinstat, M.; Biunno, I.; Balduini, A.; Tablin, F.; Shavit, J. A.; Finno, C. J.
10.1101/2025.04.30.651507 — genetics — Posted on 2025-05-06
4729 Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution
Kuo, Y.-T.; Neumann, P.; Chen, J.; Fuchs, J.; Schubert, V.; Kumke, K.; Sader, M. A.; Melzer, M.; Zhu, Z.; Himmelbach, A.; Hentrich, H.; Macas, J.; Houben, A.
10.1101/2025.05.06.652342 — evolutionary biology — Posted on 2025-05-06
4731 Multi-year study on the effects of elevated CO2 in mature oaks unravels subtle metabolic adjustments but stable biotic stress resistance
Sanchez-Lucas, R.; Raw, M.; Datta, A.; Hawkins, K.; Brettle, D.; Platt, E. A.; Ullah, S.; Hart, K.; Mayoral, C.; Stegner, M.; Kranner, I.; Hayward, S. A.; Pastor, V.; MacKenzie, A. R.; Luna, E.
10.1101/2025.05.03.652050 — plant biology — Posted on 2025-05-06
4733 A network of face patches in human prefrontal cortex for social processing of faces
Farahani, A.; Izadkhah, M.; Hamidi, R.; Yargholi, E.; Hossein-Zadeh, G.-A.; Rajimehr, R.
10.1101/2025.05.05.652210 — neuroscience — Posted on 2025-05-05
4737 High levels of Cdc42 GTPase underlie an all-or-none decision to fuse
Saha, S.; Sajeevan, A.; Merlini, L.; Vincenzetti, V.; Martin, S. G.
10.1101/2025.05.05.652171 — cell biology — Posted on 2025-05-06
4738 mRNA trafficking directs cell-size-scaling of mitochondria distribution and function
Bradbury, J. J.; Hulmes, G. E.; Viswanathan, R.; Costa, G.; Lovegrove, H. E.; Herbert, S. P.
10.1101/2025.05.05.652164 — cell biology — Posted on 2025-05-06
4740 Vitrification-warming delays preimplantation development and impairs mitochondrial function and cytoplasmic lattices integrity in mouse embryos
Barroso, M. T.; Rodriguez Munoz, J. A.; Sjöstrom, V.; Dindini, K.; Zhao, J.; Rodriguez-Wallberg, K. A.; Palomares, A. R.
10.1101/2025.05.05.652170 — cell biology — Posted on 2025-05-06
4743 Distinct roles of neuronal phenotypes during neurofeedback adaptation
Zhao, Y.; Stealey, H. M.; Lu, H.-Y.; Contreras-Hernandez, E.; Chang, Y.-J.; Tobler, P. N.; Santacruz, S. R.
10.1101/2025.05.02.651867 — neuroscience — Posted on 2025-05-05
4744 Dynamics of auditory word form encoding in human speech cortex
Zhang, Y.; Leonard, M. K.; Gwilliams, L.; Bhaya-Grossman, I.; Chang, E. F.
10.1101/2025.05.05.651964 — neuroscience — Posted on 2025-05-05
4745 Age-specific regulation of sociability by hypothalamic Agrp neurons
Iyilikci, O.; Kim, L.; Zimmer, M. R.; Bober, J.; Li, Y.; Pelts, M.; Santana, G. M.; Dietrich, M. O.
10.1101/2025.05.05.652061 — neuroscience — Posted on 2025-05-05
4746 Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across Species
Pizzagalli, D. A.; Treadway, M. T.; Kangas, B. D.; Romoli, B.; Breton, J.; Bruchas, M. R.; Graybiel, A. M.; Hueske, E.; Prakash, N.; Der-Avakian, A.; Berretta, S.; Bath, K. G.; Dulcis, D.
10.1101/2025.05.05.652258 — neuroscience — Posted on 2025-05-05
4747 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction
Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.
10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-05-05
4748 GEQO biosensors for absolute analyte quantification in single cells
Kuhn, S. M.; Nerli, E.; Liu, J.; Kaufmann, S.; Barahtjan, P.; Buitrango-Arango, M.; Geertsma, E. R.; Mateus, R.; Grapin-Botton, A.; Nadler, A.
10.1101/2025.05.05.652245 — cell biology — Posted on 2025-05-06
4749 TMEDs Mediate Versatile Cargo Transport in Vesicle-dependent Unconventional Secretion
Zheng, J.; Wang, H.; Sun, Y.; Chang, P.; Deng, X.; Zhang, L.; Zhu, L.; Zhu, K.; Deng, H.; Zhang, M.; Ge, L.
10.1101/2025.05.04.652080 — cell biology — Posted on 2025-05-06
4752 Sialin2 Senses Nitrate to Activate Endosomal PI3K-AKT-NOS Signaling
Li, X.; Jiang, O.; Cao, Z.; Zhou, B.; Chen, X.; Feng, Y.; Zhang, C.; Wang, J.; Zhou, J.; Yan, R.; Chen, M.; Wang, S.
10.1101/2025.05.04.652107 — cell biology — Posted on 2025-05-06
4754 SMG7 and eIF4A constitute a homeostatic module controlling P-body condensation and function of Meiotic bodies
Cairo, A.; Shukla, N.; Kanavorova, S.; Skalak, J.; Mikulkova, P.; Vargova, A.; Potesil, D.; Zdrahal, Z.; Hejatko, J.; Riha, K.
10.1101/2025.05.03.652043 — cell biology — Posted on 2025-05-06
4755 PKC Promotes T-Tubule Membrane Loss by Activating a PKD-NFκB Endocytic Pathway
Vilchez, A.; Pfeuffer, A.-K. M.; Wessolowski, J.; Fiegle, D. J.; Andrae, P.; Potue, P.; Kuepfer, L. K.; Shankar, T. S.; Drakos, S. G.; Selzman, C. H.; Heim, C.; Volk, T.; Seidel, T.
10.1101/2025.05.04.651469 — cell biology — Posted on 2025-05-06
4756 Biophysical and molecular mechanisms responsible for phytoplankton sinking in response to starvation
Wu, Y.; Kouadio, V. K.; Usherwood, T. R.; Li, J.; Bisher, M. E.; Aurora, R.; Lam, A. Z.; Lam, A. R.; Lytton-Jean, A. K. R.; Manalis, S. R.; Miettinen, T. P.
10.1101/2025.05.04.652135 — cell biology — Posted on 2025-05-06
4760 Integrative Analysis of Single-cell and Bulk RNA Sequencing Reveals Macrophage Heterogeneity in Lyme Arthritis
Zhou, G.; Song, C.; Dong, Y.; Chen, Y.; Luo, Y.; Liu, M.; Zhou, Y.; Yang, Y.; Chen, X.; Liu, X.; Yang, F.; Liang, Z.; Zi, L.; Gao, H.; Cao, Z.; Gao, F.
10.1101/2025.02.14.638349 — genomics — Posted on 2025-05-05
4763 Stress History Modulates CRF Neurons to Establish Resilience
Haynes, S. E.; Seo, H. S.; Lacagnina, A.; Morel, C.; Afzal, M. F.; Menigoz, A.; Clem, R.; Rajan, K.; Mayberg, H.; Young, L.; Han, M.-H.
10.1101/2022.08.31.505596 — neuroscience — Posted on 2025-05-05
4764 Temperature alone is not enough: food-web context determines evolutionary responses to warming
Han, Z.-Y.; Yuan, Y.; DeWitt, K.; Yammine, A.; Wieczynski, D. J.; Onishi, M.; Gibert, J. P.
10.1101/2024.05.06.592770 — ecology — Posted on 2025-05-05
4766 Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity
Granet, J. A.; Robertson, R.; Cusmano, A. A.; Filippelli, R. L.; Lorenz, T. O.; Li, S.; Yaqubi, M.; Stratton, J. A.; Chang, N. C.
10.1101/2024.07.24.604963 — cell biology — Posted on 2025-05-05
4767 Metabolic tagging reveals surface-associated lipoproteins in mycobacteria
Parkin, L. A.; Becker, K. L.; Maceren, J. P.; Palande, A.; Previti, M. L.; Seeliger, J. C.
10.1101/2025.01.07.631728 — microbiology — Posted on 2025-05-05
4768 Genome-directed study reveals the diversity of Salmonella T6SS effectors and identifies a novel family of lipid-targeting antibacterial toxins
Nicastro, G. G.; Sibinelli-Sousa, S.; Hespanhol, J. T.; Santos, T. W.; Munoz, J. P.; Santos, R. S.; Perez-Sepulveda, B. M.; Miyamoto, S.; Aravind, L.; de Souza, R. F.; Bayer-Santos, E.
10.1101/2024.09.27.615498 — microbiology — Posted on 2025-05-05
4772 Ultra-high throughput mapping of genetic design space
O'Connell, R. W.; Rai, K.; Piepergerdes, T. C.; Wang, Y.; Brown, L. B. C.; Samra, K. D.; Wilson, J. A.; Lin, S.; Zhang, T. H.; Ramos, E.; Sun, A.; Kille, B.; Curry, K. D.; Rocks, J. W.; Treangen, T. J.; Mehta, P.; Bashor, C. J.
10.1101/2023.03.16.532704 — synthetic biology — Posted on 2025-05-05
4777 Support for the social buffering hypothesis, especially under unpredictable precipitation regimes
Salguero-Gomez, R.; Santos, G.; Brent, L.; Gascoigne, S.; Bonsall, M. B.; Firth, J. A.; Albery, G.; Mondal, R.; Kajin, M.; Davis, K. J.
10.1101/2025.04.30.651380 — animal behavior and cognition — Posted on 2025-05-05
4780 A transcontinental experiment elucidates (mal)adaptation of a cosmopolitan plant to climate in space and time
Albano, L. J.; Bastias, C. C.; Estarague, A.; Hendrickson, B. T.; Innes, S. G.; King, N.; Patterson, C. M.; Tudoran, A.; Vasseur, F.; Puentes, A.; Violle, C.; Kooyers, N. J.; Johnson, M. T.
10.1101/2024.09.16.613311 — evolutionary biology — Posted on 2025-05-05
4782 A Versatile Toolbox for Nanoscale Interrogation of Multiprotein Assemblies inside Living Cells
Felker, A.; Philippi, M.; Holtmannspötter, M.; Drees, C.; Schäfer, E.; Steinhart, M.; Kurre, R.; You, C.; Piehler, J.
10.1101/2025.04.30.651189 — biophysics — Posted on 2025-05-05
4784 Interplay between Rac1/RhoA and actin waves in giant epithelial cells : experiment and theory
Berthoz, R.; Li, H.; Andre, M.; Lieb, M.; Hinderling, L.; Graedel, B.; Van Unen, J.; Pertz, O.; Kruse, K.; Riveline, D.
10.1101/2025.05.02.651882 — biophysics — Posted on 2025-05-05
4785 Development of Auditory and Spontaneous Movement Responses to Music over the First Year of Life
Nguyen, T.; Bigand, F.; Reisner, S.; Koul, A.; Bianco, R.; Markova, G.; Hoehl, S.; Novembre, G.
10.1101/2025.05.04.649695 — neuroscience — Posted on 2025-05-05
4790 Nuclear Myosin 1 regulates platelet activation and immune response: A novel therapeutic target for hematologic disorders
Venit, T.; Khalaji, S.; Fambri, V.; Abdrobou, W.; El Gindi, M.; Shrestha, R.; Hozak, P.; Idaghdour, Y.; Teo, J.; Percipalle, P.
10.1101/2023.02.14.528461 — cell biology — Posted on 2025-05-05
4793 Controlling the synchronization and symmetry breaking of coupled bacterial pili on active biofilm carpets
Altin, B.; Yaman, I. Y.; Günay, E. T.; Ünlü, A.; Gediz, Y.; Gedik, N.; Karatas, B.; Basaran, M.; Kocabas, C.; Özdemir, S. K.; Kocabas, A.
10.1101/2025.05.01.651758 — biophysics — Posted on 2025-05-05
4795 MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion
Mitra, T.; Rahman, J.; Hwee, M.; Jesus Faustino Ramos, R. J.; Liu, H.; Hartman, T.; Cross, J.; de Jesus, M.; Huse, M.; Longo, V.; Zanzonico, P.; Vardhana, S. A.
10.1101/2025.04.30.651453 — immunology — Posted on 2025-05-05
4796 Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease
Hawkinson, T. r.; Liu, Z.; Ribas, R. A.; Medina, T.; Nielsen, R.; Clarke, H. A.; Ma, X.; Mueller, A.; Plasencia, A.; Shear, A.; Simpson, S.; Soto, C. M.; Sudderth, J.; Cai, F.; Cantrell, A. R.; Colpert, M. G.; Shedlock, C.; Wu, L.; Young, L. E. A.; Kooser, D. D.; chen, L.; Ryan, A. M.; Azadi, P.; Deberardinis, R. J.; Prokop, S.; Allison, D.; Huang, Y.; He, X.; Bian, J.; Vander Kooi, C. W.; Gentry, M. S.; Sun, R. C.
10.1101/2025.04.30.651461 — neuroscience — Posted on 2025-05-05
4797 Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.
Hoffner, G.; Castro, P.; Uhrig, L.; Signorelli, C. M.; Dupont, M.; Tasserie, J.; Destexhe, A.; Cofre, R.; Sitt, J.; Jarraya, B.
10.1101/2024.03.27.586806 — neuroscience — Posted on 2025-05-05
4798 Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling
Nałecz-Jawecki, P.; Roth, L.; Grabowski, F.; Li, S.; Kochanczyk, M.; Bugaj, L. J.; Lipniacki, T.
10.1101/2025.04.30.651439 — systems biology — Posted on 2025-05-05
4801 Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins
Norrild, R. K.; von Bülow, S.; Halldorsson, E.; Lindorff-Larsen, K.; Rogers, J. M.; Buell, A. K.
10.1101/2024.12.21.629870 — biophysics — Posted on 2025-05-05
4802 CellAgent: LLM-Driven Multi-Agent Framework for Natural Language-Based Single-Cell Analysis
Xiao, Y.; Liu, J.; Zheng, Y.; Jiao, S.; Hao, J.; Xie, X.; Li, M.; Wang, R.; Ni, F.; Li, Y.; Wang, Z.; Shang, X.; Bao, Z.; Yang, C.; Peng, J.
10.1101/2024.05.13.593861 — bioinformatics — Posted on 2025-05-05
4804 Plant diversity shapes plant volatile emission differently at the species and community level
Medina-van Berkum, P.; Albracht, C.; Brocher, M.; Solbach, M. D.; Stein, G.; Bonkowski, M.; Buscot, F.; Heintz-Buschart, A.; Ebeling, A.; Eisenhauer, N.; El-Madany, T. S.; Huang, Y.; Kuebler, K.; Meyer, S. T.; Gershenzon, J.; Unsicker, S. B.
10.1101/2025.04.30.651392 — ecology — Posted on 2025-05-05
4806 CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency
Malacaria, E.; Figlioli, C.; Palma, A.; Rinalducci, S.; Semproni, M.; Franchitto, A.; Pichierri, P.
10.1101/2022.10.08.511087 — cell biology — Posted on 2025-05-05
4807 An Aged Microenvironment Increases CAR T Cell Cytotoxicity but Impairs Therapeutic Efficacy
Kabha, M.; Rosenzweig, N.; Rakhymzhanova, a.; Atar, O.; Cohen, C. J.; Ron-Harel, N.
10.1101/2025.05.04.652106 — immunology — Posted on 2025-05-05
4809 In vivo directed evolution of an ultra-fast RuBisCO from a semi-anaerobic environment imparts oxygen resistance
McDonald, J. L.; Shapiro, N. P.; Mengiste, A. A.; Kaines, S.; Whitney, S. M.; Wilson, R. H.; Shoulders, M. D.
10.1101/2025.02.17.638297 — biochemistry — Posted on 2025-05-05
4813 Mucosal B cell memory selection integrates tissue-specific microbial cues via the IgA BCR
Holgado, M. P.; Origlio, S.; Bertoia, L.; Moussa, M.; Trivedi, A.; Fiore, F.; Zarubica, A.; Slack, E.; Linterman, M. A.; Cogne, M.; Gregoire, C.; GAYA, M.
10.1101/2025.04.30.651421 — immunology — Posted on 2025-05-05
4814 Langerhans Cell-targeted Protein Delivery Enhances Antigen-Specific Cellular Immune Response
Rica, R.; Klein, K.; Johnson, L.; Carta, G.; Sarcevic, M.; Langer, F.; Rademacher, C.; Wawrzinek, R.; Quattrone, F.; Sparber, F.
10.1101/2025.05.05.652195 — immunology — Posted on 2025-05-05
4818 Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study
Banerjee, P.; Kuhn, J.; Pal, D. S.; Deng, Y.; Banerjee, T.; Devreotes, P. N.; Iglesias, P. A.
10.1101/2025.04.12.648264 — cell biology — Posted on 2025-05-05
4820 High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis
Woo, J.; Sun, Z.; Hu, Y.; Hoang, T. A.; Christine, D.; Katelyn, S.; Singhi, A.; Brand, R. E.; Chan, D. W.; Li, K.; Hruban, R. H.; Zhang, h.
10.1101/2025.05.01.651678 — cancer biology — Posted on 2025-05-05
4823 Molecular surface mimicry enables CRBN to target G3BP2 for degradation
Annunziato, S.; Quan, C.; Donckele, E. J.; Lamberto, I.; Bunker, R. D.; Zlotosch, M.; Schwander, L.; Murthy, A.; Wiedmer, L.; Staehly, C.; Matysik, M.; Gilberto, S.; Kapsitidou, D.; Wible, D.; De Donatis, G. M.; Trenh, P.; SriRamaratnam, R.; Strande, V.; Almeida, R.; Dolgikh, L.; DeMarco, B.; Tsai, J.; Sadok, A.; Zarayskiy, V.; Walter, M.; Tiedt, R.; Lumb, K. J.; Bonenfant, D.; Fasching, B.; Castle, J. C.; Townson, S. A.; Gainza, P.; Petzold, G.
10.1101/2025.04.30.651496 — molecular biology — Posted on 2025-05-05
4824 Jen1 transport and endocytosis in yeast reveal pH-responsive strategies to prevent metabolites loss
Barata-Antunes, C.; Warmerdam, M.; de Hulster, E.; Ribeiro, I.; Cardoso, C.; Fernandes, V.; Leite, B.; Casal, M.; Geros, H.; Pronk, J.; Arino, J.; Mans, R.; Paiva, S.
10.1101/2024.08.01.606176 — microbiology — Posted on 2025-05-05
4825 Vascular dysfunction in Huntington's disease is located at the blood-CSF barrier and is rescued by sphingosine-1-phosphate receptor agonist
Kucharz, K.; Soylu-Kucharz, R.; Saint-Pierre, M.; Alpaugh, M.; Qvist, F.; Bjorkqvist, M.; Skotte, N. H.; Cicchetti, F.; Lauritzen, M. J.
10.1101/2025.04.30.650996 — neuroscience — Posted on 2025-05-05
4826 Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control
Messanvi, F.; Visocky, V.; Senneca, C.; Berkun, K.; Taori, M.; Bradley, S. P.; Wang, H.; Tejeda, H.; Chudasama, Y.
10.1101/2024.07.29.605653 — neuroscience — Posted on 2025-05-05
4829 Mutual Inhibition Model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation
Mercker, M.; Kazarnikov, A.; Tursch, A.; Richter, T.; Özbek, S.; Holstein, T. W.; Marciniak-Czochra, A.
10.1101/2021.09.13.460125 — developmental biology — Posted on 2025-05-05
4830 NR2F2 is required in the embryonic testis for Fetal Leydig Cell development
Perea-Gomez, A.; Bellido Carreras, N.; Dhellemmes, M.; Tang, F.; Le Gallo, C.; Chaboissier, M.-C.
10.1101/2024.07.17.602099 — developmental biology — Posted on 2025-05-05
4831 Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Baako, A. K.; Vijayakumar, R.; Medina-Cano, D.; Wang, Z.; Romero-Pichardo, J.; Fadojutimi, K.; Do, S. C.; Lin, Y.; Islam, M. T.; Dixit, S.; Trzeciak, A.; Perry, J. S. A.; Vierbuchen, T.
10.1101/2025.05.01.651743 — developmental biology — Posted on 2025-05-05
4832 Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles
Oh, S.; Gudipati, D. R.; Shi, W.; Zhao, P.; Wu, W.; Boyington, J. C.; Nariya, H. K.; McGhee, E. G.; Azzam, T.; Raghunathan, V.; Yang, C.; Yang, C.; Lee, C.; Kim, J. D.; Zhou, T.; Mascola, J. R.; Wells, L.; Kong, R.
10.1101/2025.05.02.651772 — immunology — Posted on 2025-05-05
4834 Alpha activity during verbal working memory retention depends on the stimulus presentation mode
Kosachenko, A. I.; Syttykov, D. I.; Tarasov, D. A.; Kotyusov, A. I.; Kasanov, D.; Kotchoubey, B.; Pavlov, Y. G.
10.1101/2025.05.04.652111 — neuroscience — Posted on 2025-05-05
4835 Predicting individual differences of fear and cognitive learning and extinction
Gomes, C. A.; Bach, D. R.; Razi, A.; Batsikadze, G.; Elsenbruch, S.; Engler, H.; Ernst, T. M.; Fellner, M. C.; Fraenz, C.; Genc, E.; Klass, A.; Labrenz, F.; Lissek, S.; Merz, C. J.; Metzen, D.; Nostadt, A.; Pawlik, R. J.; Penate, J. E. S.; Tegenthoff, M.; Thieme, A.; Wolf, O. T.; Gunturkun, O. E.; Quick, H.; Kumsta, R.; Timmann, D.; Spisak, T.; Axmacher, N.
10.1101/2025.05.04.651880 — neuroscience — Posted on 2025-05-05
4836 Capturing individual variation in children's oscillatory brain activity during nREM sleep
Heikkinen, V.; Merz, S.; Salmelin, R.; Vanhatalo, S.; Lauronen, L.; Liljestrom, M.; Renvall, H.
10.1101/2025.05.02.651817 — neuroscience — Posted on 2025-05-05
4837 Function of the auditory cortex characterized by its intrinsic dynamic coactivation patterns estimated in individuals
Hakonen, M.; Lankinen, K.; Kotlarz, P.; Polimeni, J. R.; Turpin, T.; Ren, J.; Wang, D.; Liu, H.; Ahveninen, J.
10.1101/2025.05.04.651766 — neuroscience — Posted on 2025-05-05
4840 Holistic Motor Control of Zebra Finch Song Syllable Sequences
Trusel, M.; Zuo, J.; Alam, D.; Marks, E. S.; Koch, T. M. I.; Cao, J.; Pancholi, H.; Cooper, B. G.; Zhang, W.; Roberts, T. F.
10.1101/2025.05.04.652139 — neuroscience — Posted on 2025-05-05
4842 TDP-43 toxic gain of function links ALS, FTD and Alzheimer's Disease through splicing dysregulation
Van Zuiden, W.; Meimoun, T. D.; Bar, C.; Siany, A.; Moshe, L.; Yacovzada, N. S.; Weizman, E.; Neumann, M.; Buchman, A. S.; Wang, Y.; Bennett, D. A.; Glass, J. D.; Trautwig, A. N.; Seyfried, N. T.; Cooper-Knock, J.; Hornstein, E.
10.1101/2025.04.20.648873 — neuroscience — Posted on 2025-05-05
4844 Gap scheduling of a PARP inhibitor and nanoparticle TOP1 agent combination avoids synergistic bone marrow toxicity
Oplustil O'Connor, L.; Wang, A.; Sadler, C.; Barnes, J.; Odedra, R.; Smith, A.; Hughes, G.; Lau, A.; Tellez, A.; Eliasof, S.; Cadogan, E.; O'Connor, M. J.
10.1101/2025.04.30.651268 — cancer biology — Posted on 2025-05-05
4845 Inhibition of MLLT1 limits growth of MLL-AF4 leukaemias without killing healthy haematopoietic stem cells
Rajhansa, S.; Crump, N. T.; Khoo, H. M.; Bozhilov, Y.; Brennan, P. E.; Fedorov, O.; Adams, C.; Farnie, G.; Milne, T. A.; Wilkinson, A. C.
10.1101/2025.04.30.651417 — cancer biology — Posted on 2025-05-05
4846 Binding of extracellular vesicles to stretched von Willebrand factor promotes platelet activation
Wang, Y.; Liu, X.; Downar, T.; Topuz, A.; Bauer, A. T.; Brenna, S.; Bendas, G.; Puig, B.; Schneider, S. W.; Fedosov, D.; Gorzelanny, C.
10.1101/2025.04.30.650971 — cancer biology — Posted on 2025-05-05
4849 Computational design of conformation-biasing mutations to alter protein functions
Cavanagh, P. E.; Xue, A. G.; Dai, S.; Qiang, A.; Matsui, T.; Ting, A. Y.
10.1101/2025.05.03.652001 — biophysics — Posted on 2025-05-05
4862 Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis
Nissen, I.; Dakhel, S.; Chakraborty, C.; Nygaard, A. H.; Kirkeby, A.; Hornblad, A.; Erdem, C.; Remeseiro, S.
10.1101/2025.04.30.651564 — genomics — Posted on 2025-05-05
4864 Sialin2 Functions as a Mammalian Nitrate Sensor to Sustain Mitochondrial Homeostasis
Li, X.; Wu, S.; Cao, Z.; Jiang, O.; Li, S.; Chen, X.; Feng, Y.; Zhou, B.; Zhang, C.; Xiao, G.; Wang, J.; Zhou, J.; Chen, M.; Yan, R.; Wang, S.
10.1101/2025.05.04.652104 — cell biology — Posted on 2025-05-05
4866 Compensating Cortical Thickness for Cortical Folding-Related Variation
Demirci, N.; Coalson, T. S.; Holland, M. A.; Van Essen, D. C.; Glasser, M. F.
10.1101/2025.05.03.651968 — neuroscience — Posted on 2025-05-05
4869 Empowering multitrait brain phenotypes GWAS
Auvergne, A.; Traut, N.; Julienne, H.; Frouin, A.; Toro, R.; Aschard, h.
10.1101/2025.05.04.652120 — neuroscience — Posted on 2025-05-05
4871 Enhanced axonal transport in large vertebrates: KIF5A adaptations in giraffes and pythons
Kambara, T.; Rao, L.; Yamagishi, Y.; Ikeda, K.; Taniguchi, D.; Imasaki, T.; Shigematsu, H.; Sakai, N.; Gennerich, A.; Nitta, R.; Okada, Y.
10.1101/2025.05.04.652084 — biophysics — Posted on 2025-05-05
4872 Plastic-elastomer heterostructure for robust flexible brain-computer interfaces
Lin, X.; Zhang, X.; Wang, Z.; Chen, J.; Lee, J.; Lee, A. J.; Yang, H.; Remy, A.; Shen, H.; He, Y.; Zhao, H.; Zhang, X.; Wang, W.; Aljovic, A.; Vlassak, J. J.; Lu, N.; Liu, J.
10.1101/2025.04.29.651325 — bioengineering — Posted on 2025-05-04
4873 Exercise training remodels inter-organ endocrine networks
Ahn, C.; Hevener, A. L.; Goodyear, L. J.; Bodine, S. C.; Esser, K. A.; Seldin, M. M.; Sparks, L. M.
10.1101/2025.04.29.651323 — physiology — Posted on 2025-05-04
4875 Gene-based calibration of high-throughput functional assays for clinical variant classification
Zeiberg, D.; Tejura, M.; McEwen, A. E.; Fayer, S.; Pejaver, V.; Rubin, A. F.; Starita, L. M.; Fowler, D. M.; O'Donnell-Luria, A.; Radivojac, P.
10.1101/2025.04.29.651326 — bioinformatics — Posted on 2025-05-04
4877 A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Duggal, G.; Pettingill, P.; Lalic, T.; Gupta, S. K.; Hogsbro, C. F.; Volpato, V.; Webber, C.; Bowden, R.; Charou, D.; Arunasalam, K.; Li, X.; Maresca, M.; Hicks, R.; Chintawar, S.; Cader, Z.
10.1101/2025.04.29.651263 — neuroscience — Posted on 2025-05-04
4879 Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures
Tentori, E.; Kastellakis, G.; Maschietto, M.; Leparulo, A.; Poirazi, P.; Mazzucato, L.; Allegra, M.; Vassanelli, S.
10.1101/2025.04.29.651327 — neuroscience — Posted on 2025-05-04
4881 Adolescent intermittent ethanol exposure induces sex-specific and time-dependent changes in affective behaviors and metabolomic profiles.
Shobande, M. J.; Kumari, A.; Pearson, M.; Baker, J. A.; Hall, N. I.; Waters, R. C.; Emehel, C. E.; Hill, D.; Fowlkes, M. E.; Dean, T.; Cannady, R.; Wang, B.; Maldonado-Devincci, A. M.
10.1101/2025.04.29.651256 — neuroscience — Posted on 2025-05-04
4882 TBK1 eliminates aggregation-prone monomeric TDP-43 through the IFNβ-immunoproteasome pathway
Sakai, S.; Oiwa, K.; Iguchi, Y.; Watanabe, S.; Komine, O.; Horiuchi, M.; Katsuno, M.; Yamanaka, K.
10.1101/2025.04.29.650889 — neuroscience — Posted on 2025-05-04
4884 A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors.
Gardam, B.; Nam, E.; Kollis, P. M.; Kilyen-Coles, J.; Lenin, S.; Gliddon, B. L.; Tea, M. N.; Pitson, S. M.; Brown, M. P.; Ebert, L. M.; Gargett, T.
10.1101/2025.04.29.651335 — cancer biology — Posted on 2025-05-04
4885 Reprogramming breast cancer cells to breast cancer stem cell-like by the POU1F1 transcription factor
Concepcion, L. A.; Ruzo, S. S.; Gonzalez, S. R.; Gois, M.; Arias, M. E.; Delgado, D. M.; Lado, N.; Caballero, T. G.; Aguiar, P.; Fernandez, R. P.
10.1101/2025.04.30.651395 — cancer biology — Posted on 2025-05-04
4890 Development of an Open-source Low-cost Pressure Myography and Cardiac Flow Simulator, HemoLens, for Mechanical Characterization of Native and Engineered Blood Vessels
PereiraTavares, A. J.; Aranda-Michel, L.; Hahn, S. A.; Coffin, B. D.; Ashraf, S. F.; Szafron, J. M.; Straub, A. C.; Shiwarski, D. J.
10.1101/2025.04.29.651300 — bioengineering — Posted on 2025-05-04
4892 Human biliary atresia extrahepatic cholangiocyte organoids express increased ER and oxidative stress, altered drug metabolism and cell polarity changes
Har-Zahav, A.; Hamody, Y.; Danan, K.; Tobar, A.; Basphelchik, M.; Gurevich, M.; Shamir, R.; Gat-Viks, I.; Waisbourd-Zinman, O.
10.1101/2025.05.04.649927 — molecular biology — Posted on 2025-05-04
4894 Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats
Delorme, T. C.; Sambare, S.; Williams, B. R.; Gamble, M. C.; Solberg-Woods, L.; Maturin, L.; Palmer, A. A.; George, O.; Logan, R.
10.1101/2025.04.29.651331 — neuroscience — Posted on 2025-05-04
4898 The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques
Howell, A. M.; Warrington, S.; Fonteneau, C.; Cho, Y. T.; Sotiropoulos, S.; Murray, J. D.; Anticevic, A.
10.1101/2023.07.22.550168 — neuroscience — Posted on 2025-05-04
4899 Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution in vivo MRI from the Hippocampal Subfields Group (HSG)
Daugherty, A. M.; Carr, V.; Canada, K.; Radman, G.; Brown, T.; Augustinack, J.; Amunts, K.; Bakker, A.; Berron, D.; Burggren, A.; Chetelat, G.; de Flores, R.; Ding, S.-L.; Huang, Y.; Insausti, R.; Johnson, E.; Kanel, P.; Keresztes, A.; Kedo, O.; Kennedy, K. M.; Lee, J.; Malykhin, N.; Martinez, A.; Mueller, S.; Mulligan, E.; Ofen, N.; Palombo, D.; Pasquini, L.; Pluta, J.; Raz, N.; Riggins, T.; Rodrigue, K. M.; Saifullah, S.; Schlichting, M. L.; Stark, C.; Wang, L.; Yushkevich, P.; La Joie, R.; Wisse, L.; Olsen, R.; the Alzheimers Disease Neuroimaging Initiative, ; the Hippocampal Subfields Gro
10.1101/2025.04.29.651039 — neuroscience — Posted on 2025-05-04
4903 Ketone body mediated histone β-hydroxybutyrylation is reno-protective
Mandal, J.; Aryal, S.; Manandhar, I.; Chakraborty, S.; Mei, X.; Yeoh, B. S.; Mell, B.; Kleinhenz, A.; Tummala, R.; Yang, T.; Saha, P.; Gunning, W. T.; Vijay-Kumar, M.; Basrur, V.; de la Serna, I.; Joe, B.
10.1101/2024.12.18.628574 — physiology — Posted on 2025-05-04
4904 G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails
Fuchs, H. A.; Peng, Y.; Ayyappan, S.; Zhang, H.; Rosas, R.; Panchenko, A.; Musselman, C. A.
10.1101/2025.05.02.651932 — biophysics — Posted on 2025-05-04
4907 AI-assisted Drug Re-purposing for Human Liver Fibrosis
GUAN, Y.; Inchai, J.; Fang, Z.; Law, J.; Brito, A. A. G.; Pawlosky, A.; GottWeis, J.; Daryin, A.; Myaskovsky, A.; Palepu, A.; Rong, k.; Xu, Y.; Tu, T.; Peltz, G.
10.1101/2025.04.29.651320 — bioinformatics — Posted on 2025-05-04
4908 Bacteriophage-Loaded Microneedle Patches for Targeted andMinimally Disruptive Foodborne Pathogen Decontamination
Prasad, A.; Khan, S.; Arshad, F.; Sidhu, H.; Jackson, K.; MacLachlan, R.; Kvitka, E.; Grignano, V.; Mann, H.; Filipe, C.; Hosseinidoust, Z.; Didar, T.
10.1101/2025.04.30.651002 — bioengineering — Posted on 2025-05-04
4911 Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans
Comerford, M.; Vespasiani, D. M.; Shukla, N.; Cook, L. E.; Yermakovich, D.; Dannemann, M.; Leavesley, M.; Kinipi, C.; Ricaut, F.-X.; Brucato, N.; Cox, M. P.; Gallego Romero, I.
10.1101/2025.05.04.652069 — evolutionary biology — Posted on 2025-05-04
4912 CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder
Ghandour, T.; Glausier, J. R.; Asok, A.; Doyle, M. R.; Campo, P.; Colnaghi, L.; Lewis, D. A.; Kandel, D. B.; Kandel, E. R.; de Guglielmo, G.; Huang, S.-s. C.; Melas, P. A.
10.1101/2025.05.04.652083 — molecular biology — Posted on 2025-05-04
4913 cctbx.xfel: a suite for processing serial crystallographic data
Brewster, A. S.; Paley, D. W.; Bhowmick, A.; Mittan-Moreau, D. W.; Young, I. D.; Mendez, D.; Tchon, D. M.; Poon, B. K.; Sauter, N. K.
10.1101/2025.05.04.652045 — molecular biology — Posted on 2025-05-04
4914 Acidification by nitrogen metabolism triggers extracellular biopolymer production in an oleaginous yeast
Sepulveda Del Rio Hamacek, H.; Tingajeva, O.; Ostertag, K.; Rekena, A.; Illarionov, A.; Joul, P.; Monteiro de Oliveira, P.; de La Caridad Martin-Hernandez, G.; Müller, B.; Bonturi, N.; Passoth, V.; Lahtvee, P.-J.; Kumar, R.
10.1101/2025.05.04.652101 — microbiology — Posted on 2025-05-04
4915 Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity
Maldonado, J. S.; Sepulveda, S.; Karthikeyan, S.; Shirakawa, K. T.; Merced, I.; Radecki, A. A.; Douglas, J.; Peti, W.; Page, R.; Vargas-Rodriguez, O.
10.1101/2025.05.04.652006 — biochemistry — Posted on 2025-05-04
4916 Support for the social buffering hypothesis, especially under unpredictable precipitation regimes
Salguero-Gomez, R.; Santos, G.; Brent, L.; Gascoigne, S.; Bonsall, M. B. F.; Firth, J. A.; Albery, G.; Mondal, R.; Kajin, M.; Davis, K. J.
10.1101/2025.04.30.651380 — animal behavior and cognition — Posted on 2025-05-04
4917 Bridging Hearts and Muscles: Genetic Insights into Cardiac Structure and Sarcopenia
Wang, C.; Xie, W.; Zhu, Y.; Liu, Z.; Yang, G.; Zhong, D.; Li, Y.; Zhao, S.
10.1101/2025.04.29.651359 — genetics — Posted on 2025-05-04
4918 CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization
Kovacs, B.; Somogyi, F.; Szabo, V.; Nagy, Z. Z.; Hernadi, I.; Matyas, F.; Vanduffel, W.; Szemlaky, Z.; Rozsa, B.; Ulbert, I.; Hillier, D.
10.1101/2025.04.30.651383 — immunology — Posted on 2025-05-04
4919 Virus glycoprotein nanodisc platform for vaccine design
Rantalainen, K.; Liguori, A.; Ozorowski, G.; Flynn, C.; Steichen, J. M.; Swanson, O.; Madden, P. J.; Baboo, S.; Phulera, S.; Gharpure, A.; Lu, D.; Kalyuzhniy, O.; Skog, P.; Terada, S.; Shil, M.; Diedrich, J. K.; Georgeson, E.; Tingle, R.; Eskandarzadeh, S.; Lee, W.-H.; Goodwin, D.; Alavi, N.; Kubitz, M.; Amirzehni, S.; Himansu, S.; Sok, D.; Lee, J. H.; Yates, J. R.; Paulson, J. C.; Crotty, S.; Schiffner, T.; Ward, A. B.; Schief, W. R.
10.1101/2025.05.02.651272 — immunology — Posted on 2025-05-04
4921 Factors Influencing Monoclonal Antibody Pharmacokinetics Across Varying Immune Perturbations
DeBonis, J.; Davis, A.; Wang, Z.; Fell, C.; Diehl, M.; Igoshin, O. A.; Veiseh, O.
10.1101/2025.04.29.651349 — immunology — Posted on 2025-05-04
4922 Housing environment bilaterally alters transcriptomic profile in the rat hippocampal CA1 region
Kubota, A.; Kojima, K.; Koketsu, S.; Kannon, T.; Sato, T.; Hosomichi, K.; Shinohara, Y.; Tajima, A.
10.1101/2025.04.29.651351 — neuroscience — Posted on 2025-05-04
4924 Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth
Ma, Y.; Ayadhury, S.; Singh, S.; Vashishath, Y.; Ozdemir, C.; McKee, T.; Nguyen, N.; Basi, A.; Mak, D.; Gomez, J.; Huse, J.; Noor, S.; Winkowski, D.; Baird, R.; Weinberg, J.; Lang, F.; Burks, J.; Bozdag, S.; Seeley, E.; Ene, C.
10.1101/2025.04.30.651361 — cancer biology — Posted on 2025-05-04
4926 Understanding the physical processes behind DNA-DNA proximity ligation assays
Zubillaga Herrera, B. J.; Das, A.; Burack, L. R.; Wang, A.; Di Pierro, M.
10.1101/2025.05.02.649190 — biophysics — Posted on 2025-05-04
4928 Postoperative Stress Accelerates Atherosclerosis through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport
Boucher, D. M.; Rochon, V.; Laval, T.; Lorant, V.; Carter, A.; Emerton, C.; Joyce, N.; Vinayak, N.; Scaffidi, M.; Auer, R. C.; Gordon, S. M.; Ouimet, M.
10.1101/2025.05.02.651357 — biochemistry — Posted on 2025-05-04
4929 Understanding the population structure of Moraxella catarrhalis using core genome multilocus sequence typing (cgMLST) and a life identification number (LIN) code classification system
Yassine, I.; Jolley, K. A.; Bray, J. E.; Jansen van Rensburg, M. J.; Patel, F.; Sheppard, A. E.; Zar, H. J.; Allen, V.; Ah Tow, L.; Maiden, M. C. J.; Nicol, M. P.; Brueggemann, A. B.
10.1101/2025.04.30.651387 — genomics — Posted on 2025-05-04
4930 Predicting forest tree leaf phenology under climate change using satellite monitoring and population-based GWAS
Pfenninger, M.; Langan, L.; Feldmeyer, B.; Eberhardt, L.; Reuss, F.; Hofmann, J.; Fussi, B.; Seho, M.; Mellert, K.-H.; Hickler, T.
10.1101/2025.04.30.651385 — evolutionary biology — Posted on 2025-05-04
4931 Context-Dependent Adaptation in Structured Environments
Karita, Y.; Rodriguez-Sanchez, G. T.; Brambilla, E.; Hernandez-Beltran, J. C. R.; Schwarz, M.; Rainey, P. B.
10.1101/2025.04.29.651346 — evolutionary biology — Posted on 2025-05-04
4933 No association between metabolic rate and an exaggerated sexually selected trait
Matsumura, K.; Noda, T.; Sharma, M. D.; Okada, K.; Miyatake, T.; Hosken, D. J.
10.1101/2025.04.29.651352 — ecology — Posted on 2025-05-04
4936 Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel genomically humanised SOD1A4V mice.
Thompson, D.; Williams, C.; Tosolini, A. P.; Gilthorpe, J.; Schiavo, G.; Fisher, E. M.; Cunningham, T. J.
10.1101/2025.05.01.650597 — neuroscience — Posted on 2025-05-04
4937 Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety
Mourra, D.; Murphy, C. E.; Hourany, E.; Centeno, K.; Gnazzo, F.; Beeler, J. A.
10.1101/2025.04.29.651295 — neuroscience — Posted on 2025-05-04
4939 PEtab.jl: Advancing the Efficiency and Utility of Dynamic Modelling
Cvijovic, M.; Persson, S.; Frohlich, F.; Grein, S.; Lomna, T.; Ognissanti, D.; Hassselgren, V.; Hasenauer, J.
10.1101/2025.04.30.651378 — systems biology — Posted on 2025-05-04
4942 Saddle Curvature Association of nsP1 Facilitates the Replication Complex Assembly of Chikungunya Virus in Cells
Miao, X.; Law, M. C. Y.; Kumar, J.; Chng, C. P.; Zeng, Y.; Tan, Y. B.; Wu, J.; Guo, X.; Huang, L.; Zhuang, Y.; Gao, W.; Huang, C.; Luo, D.; Zhao, W.
10.1101/2025.05.01.641776 — biophysics — Posted on 2025-05-04
4943 Enhancing Neural Synchrony with Endogenous-like 1/f Noise Stimulation
Ping, A.; Guan, L.; Gu, H.; Jiang, Z.; Deng, W.; Chen, H.; Zeng, K.; Li, X.
10.1101/2025.04.30.651370 — biophysics — Posted on 2025-05-04
4944 SarcAsM: AI-based multiscale analysis of sarcomere organization and contractility in cardiomyocytes
Haertter, D.; Hauke, L.; Driehorst, T.; Nishi, K.; Long, J.; Tiburcy, M.; Berecic, B.; Primessnig, A.; Bao, G.; Cyganek, L.; Schmidt, C. F.; Zimmermann, W. H.
10.1101/2025.04.29.650605 — bioinformatics — Posted on 2025-05-04
4945 Frequency-Dependent Neurostimulation in Whole Brain Network models
Otero, M.; Poo, E.; Torres, F.; Mendoza, C.; Lea-Carnall, C. A.; Weinstein, A.; Guevara, P.; Prado, P.; Cabral, J.; EL-DEREDY, W.
10.1101/2025.04.30.651283 — bioengineering — Posted on 2025-05-04
4949 Metagenomes and Metagenome-Assembled Genomes from Tidal Lagoons at a New York City Waterfront Park
Kong, S.; Abrams, E.; Binik, Y.; Cappelli, C.; Chu, M.; Cornett, T.; Culbertson, I.; Garcia, E.; Henry, J.; Lam, K.; Lampman, D.; Morenko, G.; Rivera, I.; Swift, T.; Torres, I.; Velez, R.; Waxman, E.; Wessely, S.; Yuen, A.; Lardner, C. K.; Weissman, J.
10.1101/2025.05.01.651762 — microbiology — Posted on 2025-05-04
4950 A Fundamental Approach to Buoyant Density Determination by DGE-AUC
Yarawsky, A. E.; Cardenas Lopez, P.; Walter, J.; DeLion, M. T.; Paul, L. N.
10.1101/2025.04.28.650698 — biophysics — Posted on 2025-05-04
4951 Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system
Azieh, A.; Hernandez, P. R.; Anderson, A. C.; Sychantha, D.; Verster, A. J.; Whitney, J.; Ross, B. D.
10.1101/2025.05.03.651265 — microbiology — Posted on 2025-05-04
4953 The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales
Cartagena, A. J.; Taylor, K. L.; Lopez, L. C.; Su, J.; Smith, J. T.; Manson, A. L.; Chen, J. D.; Pierce, V. M.; Earl, A. M.; Bhattacharyya, R. P.
10.1101/2023.05.23.541813 — microbiology — Posted on 2025-05-04
4956 Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis
Daunesse, M.; Sundaram, V.; Kentepozidou, E.; Connelly, J.; Anderson, C. J.; Liver Cancer Evolution Consortium, ; Lopez-Bigas, N.; Semple, C.; Odom, D. T.; Taylor, M. S.; Roller, M.; Aitken, S. J.; Flicek, P.
10.1101/2025.02.11.637769 — cancer biology — Posted on 2025-05-04
4957 Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging
Williamson, D. J.; Zaza, C.; Carlon Andres, I.; Gentili, A.; Daly, J. I.; Holmes, H.; Thrush, J.; Starling, T.; Neil, S.; Owens, R.; Malim, M. M.; Tynan, C.; Simoncelli, S.; Padilla-Parra, S.
10.1101/2025.04.11.648405 — biophysics — Posted on 2025-05-04
4960 Disease-associated loci share properties with response eQTLs under common environmental exposures
Lin, W.; Li, M.; Allen, O.; Burnett, J.; Popp, J. M.; Stephens, M.; Battle, A.; Gilad, Y.
10.1101/2025.04.30.651602 — genetics — Posted on 2025-05-04
4961 Proteomic profiling of primary cilia in the developing brain uncovers newregulators of cortical development
Liu, X.; Torres Gutierrez, O.; Kaur, G.; Al-Issa, Y.; Baboo, S.; Diedrich, J. K.; Cai, E.; Yates, J. R.; Ge, X.
10.1101/2025.05.03.652041 — developmental biology — Posted on 2025-05-04
4963 Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation
Schultz, C. W.; Saha, S.; Dhall, A.; Zhang, Y.; Desai, P.; Pongor, L. S.; Scheiblin, D. A.; Magidson, V.; Sun, Y.; Redon, C.; Kumar, S.; Krishnamurthy, M.; Dias, H. B.; Aksenova, V.; Giordano, E.; Takahashi, N.; Nirula, M.; Arora, M.; Tabe, C.; Thomas, M.; Kumar, R.; Arakawa, Y.; Jo, U.; Teicher, B. A.; Aladjem, M. I.; Lockett, S.; Dasso, M.; Pommier, Y.; Sharma, A. K.; Thomas, A.
10.1101/2025.04.29.651052 — cancer biology — Posted on 2025-05-03
4965 nanoFOLD : sequence design of nanobodies via inverse folding
Chomicz, D.; Janusz, B.; Wrobel, S.; Dudzic, P.; Polasa, A.; Martin, K.; Darnell, S.; Comeau, S. R.; Krawczyk, K.
10.1101/2025.04.29.651236 — bioinformatics — Posted on 2025-05-03
4966 13C tracing in synaptosomes reveals that SGLT2 inhibition with dapagliflozin prevents metabolic deficits in the 5X-FAD model of Alzheimer's Disease
Mekkittikul, M.; Zhu, C.; Danna, B. T.; Zuo, X.; Rios, A.; Yang, K.; Villanueva, M.; Agarwal, D.; Castro, D.; Gu, X.; Strofs, A. R.; Shirihai, O. S.; Stiles, L.; Frautschy, S. A.; Oscarsson, J.; Esterline, R. L.; Cole, G. M.; Divakaruni, A. S.
10.1101/2025.04.30.651373 — biochemistry — Posted on 2025-05-03
4971 Virion stripping: A new role for bacterial proteases
Rodriguez-Hernandez, C. J.; Terekhova, M.; Chen, P.; Perpich, J.; Potempa, B.; Carey, K. A.; Peeples, M. E.; Grayson, M. H.; Potempa, J.; Artyomov, M.; Lamont, R. J.; Bagaitkar, J.
10.1101/2025.05.03.652018 — microbiology — Posted on 2025-05-03
4973 EpiMII: Integrating Structure and Graph Neural Networks for MHC-II Epitope and Neoantigen Design
Yuan, J.; Xu, X.; Sun, Z.-Y.; Liang, T.; Ge, J.; Jin, R.; Xie, X.-Q.; Chen, Y.; Hou, T.; Feng, Z.
10.1101/2025.04.29.651031 — immunology — Posted on 2025-05-03
4974 Aligned representation of visual and tactile motion directions in hMT+/V5 and fronto- parietal regions
Shahzad, I.; Battal, C.; Cerpelloni, F.; Van Audenhaege, A.; Mouraux, A.; Collignon, O.
10.1101/2025.03.24.645080 — neuroscience — Posted on 2025-05-03
4975 Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions
Klug, J. R.; Yan, X.; Hoffman, H.; Engelhardt, M. D.; Osakada, F.; Callaway, E.; Jin, X.
10.1101/2023.10.02.560589 — neuroscience — Posted on 2025-05-03
4979 Improving RNA Secondary Structure Prediction Through ExpandedTraining Data
Langeberg, C. J.; Kim, T.; Nagle, R.; Meredith, C.; Garuadapuri, D. A.; Doudna, J. A.; Cate, J. H. D.
10.1101/2025.05.03.652028 — bioinformatics — Posted on 2025-05-03
4981 Strain-level metagenomic profiling using pangenome graphs with PanTax
Luo, X.; Zhang, W.; Liu, Y.; Li, G.; Xu, J.; Chen, E.; Schonhuth, A.
10.1101/2025.04.29.651271 — bioinformatics — Posted on 2025-05-03
4982 Advancing Therapeutic Solutions: Poloxamer-based Thermosensitive Injectable Hydrogels containing a Self-assembling Peptide for In situ Gelation in an Osteoarthritis Murine Model
Sayedipour, S.; Schomann, T.; van de Looij, S. M.; Rezaie, S.; Ramos, Y. F. M.; Vermonden, T.; van der Weerd, L.; Meulenbelt, I.; Cruz, L. J.
10.1101/2025.04.30.651282 — biochemistry — Posted on 2025-05-03
4987 Open Educational Resources for distributed hands-on teaching in molecular biology
Cerda Rojas, A.; Aravena, A.; Arce, A.; Zapata, V.; Araya, W.; Gallardo, D.; Aviles, J.; Quero, F.; Nunez, I.; Matute, T.; Navarro, F.; Ferrando, V.; Blanco, M.; Velozo, S.; Aguilera, S.; Chateau, F.; Olivares, R.; Molloy, J. C.; Aidelberg, G.; Lindner, A. B.; Castro, F.; Cremades, P.; Ramirez-Sarmiento, C. A.; Federici, F.
10.1101/2024.03.28.587173 — molecular biology — Posted on 2025-05-03
4991 Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system
Ross, B. D.; Whitney, J.; Verster, A. J.; Hernandez, P. R.; Azieh, A.; Anderson, A. C.; Sychantha, D.
10.1101/2025.05.03.651265 — microbiology — Posted on 2025-05-03
4992 Imbalance in gut microbial interactions as a marker of health and disease
Lopez, R. C.; Bonachela, J. A.; Dominguez-Bello, M. G.; Manhart, M.; Levin, S. A.; Blaser, M. J.; Munoz, M. A.
10.1101/2025.04.30.651474 — microbiology — Posted on 2025-05-03
4995 Cross-order detection of bacteriophage transduction in communities using ribosomal RNA barcoding
LaTurner, Z. W.; Dysart, M. J.; Schwartz, S. K.; Zeng, E.; Chappell, J.; Silberg, J. J.; Stadler, L. B.
10.1101/2025.05.03.652062 — synthetic biology — Posted on 2025-05-03
4998 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction
Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.
10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-05-03
4999 Stretchable, hair-compatible, and long-term stable wearable EEG system
Hsieh, J.-C.; Yao, M.; Alawieh, H.; Koptelova, V.; Kumar, S.; Tang, K. K. W.; Wang, W.; Jeong, J.; Ding, H.; Chae, T.; Ahmad, Z.; Wang, D.; Engrav, T.; Wang, R.; Gupta, A.; He, W.; Moscoso-Barrera, W. D.; Grimes, A.; Millan, J. d. R.; Wang, H.
10.1101/2025.04.28.651043 — bioengineering — Posted on 2025-05-03
5000 Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction
Sato, M.; Tanabu, D.; Torigoe, D.; Kadomatsu, T.; Taniwaka, K.; Ogata, Y.; Shiiba, I.; Suzuki, Y.; Inatome, R.; Tokuyama, T.; Takeiwa, T.; Inoue, S.; Kanai, E.; Hamano, T.; Hirata, H.; Kanamitsu, K.; Kusuhara, H.; Yokosuka, A.; Mimaki, Y.; Abe, H.; Oike, Y.; Yanagi, S.
10.1101/2025.05.01.651794 — biochemistry — Posted on 2025-05-03
5001 Chromosome scale genomes of two invasive Adelges species identifieshost immunity and developmental gene targets for selective pest control
Glendening, A. M.; Stephens, C.; Vuruputoor, V. S.; Stern, D. L.; Hogenhout, S. A.; Mathers, T. C.; Chaganti, T.; Pauloski, N.; Cernak, T. A.; Wegrzyn, J. L.; Fetter, K. C.
10.1101/2024.11.21.624573 — genomics — Posted on 2025-05-03
5002 Exposure to per- and polyfluoroalkyl substances elicits cell type-specific impacts on p53 and TGF-β signaling pathways
Ding, H.; Slack, M.; McClure, H.; Gu, W.; Nabinger, C.; Koviazina, R.; Gu, H.; Kappes, F.; Schultz, T.; Somarelli, J.; Tsigkou, A.
10.1101/2025.05.03.652004 — molecular biology — Posted on 2025-05-03
5004 Genome-Wide Identification of Conditionally Essential Genes Supporting Streptococcus suis Growth in Serum and Cerebrospinal Fluid
Juanpere Borras, M.; Zhao, T.; Boekhorst, J.; Fernandez-Ciruelos, B.; Sanyal, R.; Arifa, N.; Wagenaar, T.; van Baarlen, P.; Wells, J.
10.1101/2025.05.03.652005 — microbiology — Posted on 2025-05-03
5005 Integrating simulated and experimental data to identify mitochondrial bioenergetic defects in Parkinson's Disease models
Chenna, S.; Joselin, A.; Bano, D.; Pizzo, P.; Ankarcrona, M.; Park, D. S.; Prehn, J. H.; Connolly, N. M. C.
10.1101/2025.04.29.651221 — neuroscience — Posted on 2025-05-03
5007 Phenotypic and Functional Characterization of Oncohistone Mutations in Breast Cancers
Edwards, A. D.; Dai, Y.; Singh, S.; Thornton, M.; Nandu, T.; Kittler, R.; Camacho, C. V.; Huang, D.; Kraus, W. L.
10.1101/2025.04.29.651098 — cancer biology — Posted on 2025-05-03
5008 NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
Xu, Y.; Nipper, M.; Dominguez, A.; He, C.; Sharkey, F.; Khan, S.; Xu, H.; Zhou, D.; Zheng, L.; Luan, Y.; Liu, J.; Wang, P.
10.1101/2025.04.29.651251 — cancer biology — Posted on 2025-05-03
5010 AbBFN2: A flexible antibody foundation model based on Bayesian Flow Networks
Guloglu, B.; Braganca, M.; Graves, A.; Cameron, S.; Atkinson, T.; Copoiu, L.; Laterre, A.; Barrett, T. D.
10.1101/2025.04.29.651170 — bioinformatics — Posted on 2025-05-03
5011 Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal
Mitchell, J. T.; Stapleton, O.; Krishnan, K.; Nagaraj, S.; Lvovs, D.; Cherry, C.; Poissonnier, A.; Horton, W.; Adey, A.; Rao, V.; Huff, A.; Zimmerman, J. W.; Kagohara, L. T.; Zaidi, N.; Coussens, L. M.; Jaffee, E. M.; Elisseeff, J. H.; Fertig, E. J.
10.1101/2025.05.02.651747 — bioinformatics — Posted on 2025-05-03
5016 Condensin Accelerates Long-Range Intra-Chromosomal Interactions
Zou, F.; Li, Y.; Foldes, T.; Pinholt, H. D.; Smith, C.; Mirny, L.; Bai, L.
10.1101/2025.05.02.651983 — molecular biology — Posted on 2025-05-03
5019 A transgenic mouse allows to capture the HLA-C*06:02 immunopeptidome in a model of psoriasis
Braun, A.; Mobbs, J. I.; Chung, S.; Tuomisto, J. E.; Li, C.; Scull, K. E.; Ayala, R.; Anand, S.; Ramarathinam, S.; Kern, J. S.; Fourie, A.; McKinnon, M.; Baker, D. G.; Rao, N.; Mifsud, N. A.; Illing, P. T.; Vivian, J. P.; Rossjohn, J.; Purcell, A. W.
10.1101/2025.05.01.651638 — immunology — Posted on 2025-05-03
5020 Isolation of Neural Stem Cells Using Platelet Derived Growth Factor C
Omairi, H. K.; Meode, M.; Sait, S.; heemskerk, K. M.; Black, S.; Chan, J. A.; Cairncross, J. G.
10.1101/2025.04.29.650770 — neuroscience — Posted on 2025-05-03
5021 Automatic Individual Cortical Parcellation for the Human Connectome Project
Yang, C.; Coalson, T. S.; Farahibozorg, S.-R.; Bijsterbosch, J. D.; Smith, S. M.; Van Essen, D. C.; Glasser, M. F.
10.1101/2025.04.29.651219 — neuroscience — Posted on 2025-05-03
5024 Pervasive phenotypic effects of Fbxo42 controlled by regulation of PP4 phosphatase
D'Angiolella, V.; Yang, H.; Smith, P.; Ma, Y.; Southworth, E.; Gopala-Krishna, V.; Salerno, B.; Rowland, J. M. S.; Grieco, D.; Kessler, B. M.; Fischer, R.
10.1101/2025.05.02.651838 — biochemistry — Posted on 2025-05-03
5028 A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver
Mohammed, S.; Jiang, C.; Pennington, T.; Bhaskaran, S.; Ohene-Marfo, P.; Georgescu, C.; Pitts, K.; Tran, A.; Peng, Z.; Singh, A.; Yang, Z.; Li, T.; Hannafon, B.; Houchen, C.; Wren, J. D.; Galvan, V.; Ahsan, N.; Kinter, M.; Lewis, T. L.; Deepa, S. S.
10.1101/2025.05.02.651782 — cell biology — Posted on 2025-05-03
5029 Loss of circulating glucocorticoid rhythm disrupts the circadian transcriptome and vascular reactivity in the mouse renal artery
Krilis, G.; Costello, H. M.; Turner, F.; Little, R.; Komolova, A.; Nespoux, J.; Czopek, A.; Dunbar, D. R.; Bailey, M. A.; Ivy, J. R.
10.1101/2025.04.29.650449 — physiology — Posted on 2025-05-03
5030 Spatialproteomics - an interoperable toolbox for analyzing highly multiplexed fluorescence image data
Meyer-Bender, M. F.; Voehringer, H. S.; Schniederjohann, C.; Koziel, S. P.; Chung, E. K.; Popova, E.; Brobeil, A.; Held, L.-M.; Munir, A.; Scverse Community, ; Dietrich, S.; Bruch, P.-M.; Huber, W.
10.1101/2025.04.29.651202 — bioinformatics — Posted on 2025-05-03
5031 Deciphering Biosynthetic Gene Clusters with a Context-aware Protein Language Model
Kang, Z.; Zhang, H.; Liang, C.; Yang, R.; Ye, Y.; Bai, H.; Zhang, Y.; Ning, K.
10.1101/2025.04.29.651206 — bioinformatics — Posted on 2025-05-03
5035 Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis
Ashford, A. L.; Nachmanson, D.; Wills, J. W.; Higgins, J. E.; Smith, T. H.; Vavra, K. C.; Dahalan, F.; Howe, J.; Elloway, J. M.; Salk, J. J.; Doherty, A.; Lynch, A. M.
10.1101/2025.04.29.651210 — pharmacology and toxicology — Posted on 2025-05-03
5041 A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
Jones, L.; Rukhlenko, O. S.; Dias, T.; Imoto, H.; Carmody, C.; Wynne, K.; Kholodenko, B. N.; Bond, J.
10.1101/2025.04.29.651188 — cancer biology — Posted on 2025-05-03
5050 Allocation of resources among multiple daughter cells
Wirshing, A. C. E.; Alonso Matilla, R.; Yan, M.; Khalid, S.; Colarusso, A. V.; Odde, D. J.; Lew, D. J.
10.1101/2025.05.02.651883 — cell biology — Posted on 2025-05-03
5051 Specialized high-capacity mitochondria fuel cell invasion
Kenny-Ganzert, I. W.; Basta, L. P.; Wang, L.; Chi, Q.; Su, C.; Morton, K.; Meyer, J.; Sherwood, D. R.
10.1101/2025.05.02.651978 — cell biology — Posted on 2025-05-03
5052 TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin
Liang, J.; Wang, Y.; Demmerle, J.; He, B. J.; Ricketts, C. J.; Linehan, W. M.; Zang, C.; Cai, D.
10.1101/2025.05.02.651992 — cell biology — Posted on 2025-05-03
5059 Vernalization regulatory network identifies potential novel functions for ZCCT genes within HvVRN2
Montardit-Tarda, F.; Puyo, I.; Contreras-Moreira, B.; Karsai, I.; Borrill, P.; Casas, A. M.; Igartua, E.
10.1101/2025.04.29.651237 — plant biology — Posted on 2025-05-03
5061 SNRK3.15 is a crucial component of the sulfur deprivation response in Arabidopsis thaliana
Apodiakou, A.; Heyneke, E.; Alseekh, S.; Pinsorn, P.; Metzger, S.; Kopriva, S.; Schulze, W.; Hoefgen, R.; Whitcomb, S. J.
10.1101/2025.04.29.651231 — plant biology — Posted on 2025-05-03
5065 Recurrent Emergence of Boundary Cell Types During Evolution of Floral Bullseye Patterns
Oud, S.; Zurowski, M. M.; van der Jagt, P. L.; Yeo, M. T. S.; Walker, J. F.; Moyroud, E.; Vroomans, R. M. A.
10.1101/2025.05.03.651954 — systems biology — Posted on 2025-05-03
5066 A moss N-Acetyltransferase-MAPK protein controls 2D to 3D developmental transition via acetylation and phosphorylation changes
de Luxan Hernandez, C.; Ammitsoe, T. J.; Kanne, J. V.; Stanimirovic, S.; Roux, M.; Weeks, Z.; Schutzbier, M.; Dürnberger, G.; Roitinger, E.; Zhang, L.; Spadiut, O.; Ishikawa, M.; Hasebe, M.; Moody, L.; Dagdas, Y.; Rodriguez, E.; Petersen, M.
10.1101/2025.05.02.650421 — plant biology — Posted on 2025-05-03
5067 Modulation of the GT Family 47 clade B gene affects arabinan deposition in elaters of Marchantia polymorpha
Kang, H. S. F.; Lampugnani, E. R.; Tong, X.; Prabhakar, P. K.; Flores-Sandoval, E.; Hansen, J.; Jorgensen, B.; Bowman, J. L.; Urbanowicz, B. R.; Ebert, B.; Persson, S.
10.1101/2025.05.02.651808 — plant biology — Posted on 2025-05-03
5072 Nucleosome placement and polymer mechanics explain genomic contacts on 100kbp scales
Corrette, J.; Li, J.; Shao, H.; Veerasubramanian, P. K.; Spakowitz, A.; Downing, T. L.; Allard, J.
10.1101/2024.09.24.614727 — biophysics — Posted on 2025-05-03
5077 Osteocyte Nicotinic Acetylcholine Receptors Impact Bone Mechanoadaptation in a Sexually Dimorphic Manner
Mora-Antoinette, M.; Garcia-Ortiz, A.; Obaji, M.; Saffari, A. W.; Matthews, M. D.; Wasi, M.; Lewis, K. J.
10.1101/2023.10.01.556129 — physiology — Posted on 2025-05-03
5079 Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
Liu, X.; Cortes, E.; Ji, Y.; Zhao, K.; Ho, J.; Liu, Y. S.; Davicioni, E.; Feng, F. Y.; Alumkal, J. J.; Spratt, D. E.; Sweeney, C. J.; Yu, H.; Hu, Q.; Cheng, Z.; Zhang, D.; Chatta, G.; Nastiuk, K. L.; Goodrich, D. W.; Rycaj, K.; Jamroze, A.; Kirk, J. S.; Puzanov, I.; Liu, S.; Wang, J.; Tang, D. G.
10.1101/2025.04.27.650697 — cancer biology — Posted on 2025-05-03
5087 Mitochondrial structure despite nuclear panmixia: sex-specific dispersal dictates population structure in sperm whales
Brennan, R.; Talbot, L. W.; Martinez, A.; Garrison, L. P.; Engelhaupt, D.; Vollmer, N. L.; Rosel, P. E.
10.1101/2025.04.29.651281 — evolutionary biology — Posted on 2025-05-02
5089 Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes
Li, J.; Tanzillo, A.; Pizzirusso, G.; Caccavano, A. P.; Chittajallu, R.; Sohn, M.; Abebe, D.; Zhang, Y.; Pelkey, K.; Dale, R.; McBain, C. J.; Petros, T. J.
10.1101/2025.05.02.651761 — neuroscience — Posted on 2025-05-02
5092 Stenotrophomonas maltophilia exhibits defensive multicellularity in response to a Pseudomonas aeruginosa quorum sensing molecule
Katharios-Lanwermeyer, S.; Zarrella, T. M.; Godsil, M.; Severin, S.; Casiano, A. E.; Tai, C.-H.; Khare, A.
10.1101/2025.05.02.651457 — microbiology — Posted on 2025-05-02
5095 Calpain cleaves the carboxyl terminus of TRPV1 and modulates receptor tachyphylaxis
Jiang, J.; Wang, X.; Yang, J.; Gao, S.; Xu, J.; Liu, J.; Wang, Y.; Liang, P.; Zhang, Y.
10.1101/2025.04.28.651151 — neuroscience — Posted on 2025-05-02
5097 Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP
Kirk, L. M.; Garcia, G. C.; Hanka, D. C.; Zatyko, K.; Bartol, T. M.; Sejnowski, T. J.; Harris, K. M.
10.1101/2025.04.29.651313 — neuroscience — Posted on 2025-05-02
5098 MILD TRAUMATIC BRAIN INJURY IMPAIRS EPISODIC MEMORY IN RATS
Nah, G.; Antonopoulos, M.; Hohmann, A. G.; Port, N.; Crystal, J. D.
10.1101/2025.04.28.651041 — neuroscience — Posted on 2025-05-02
5100 Modular Engineering of Thermo-Responsive Allosteric Proteins
Hoffmann, K. H.; Kroell, A.-S.; Motzkus, N. A.; Lemmen, N.; Happ, N.; Wolf, B.; von Bachmann, A.; Southern, N.; Vogd, F.; Aschenbrenner, S.; Niopek, D.; Mathony, J.
10.1101/2025.05.02.651844 — synthetic biology — Posted on 2025-05-02
5101 Early-life PBDE flame retardant exposures cause neurobehavioral alterations in fish that persist into adulthood and vary by sex and route of exposure
McNabb-Kelada, N.; Burke, T.; Jayaraman, S.; Mills, L.; De La Torre, A.; Francoeur, M.; Schraeder, H.; Nacci, D.; Clark, B. W.; Whitehead, A.
10.1101/2025.04.28.651140 — pharmacology and toxicology — Posted on 2025-05-02
5102 TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma
Asad, M.; Inocencio, J.; Mitrasinovic, S.; Aoki, M.; Crisman, C.; Lasala, P.; Eskandar, E.; Guha, C.; Zang, X.; Parney, I. F.; Himes, B. T.
10.1101/2025.04.24.648993 — cancer biology — Posted on 2025-05-02
5103 A telomere to telomere phased genome assembly and annotation for the Australian central bearded dragon Pogona vitticeps
Patel, H. R.; Alreja, K.; Reis, A. M.; Chang, J. K.; Chew, Z. A.; Jung, H.; Hammond, J. M.; Deveson, I. W.; Ruiz-Herrera, A.; Marin-Gual, L.; Holleley, C. E.; Zhang, X.; Lister, N. C.; Whiteley, S. L.; Xiong, L.; Dissanayake, D. S. B.; Waters, P. D.; Georges, A.
10.1101/2025.05.01.651798 — genomics — Posted on 2025-05-02
5106 HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy
Rivault, A.; Bernut, A.; Ben-Neji, M.; Abrantes, M.; Jansen, M.; Huc-Brandt, S.; Besteiro, S.; Bordat, Y.; Audemard, N.; Mesleard-Roux, M.; Perrais, D.; Neyrolles, O.; Lugo-Villarino, G.; Verollet, C.; Espert, L.; BEAUMELLE, B.
10.1101/2025.05.02.651870 — microbiology — Posted on 2025-05-02
5107 Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei
Banerjee, S.; Minshall, N.; Cook, A. D.; Macleod, O.; Webb, H.; Higgins, M. K.; Carrington, M.
10.1101/2025.05.02.651885 — microbiology — Posted on 2025-05-02
5112 Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning
Shlesinger, D.; Sadilek, V.; Minot, M.; Stamkopoulos, E.; Bikias, T.; Kuhn, R.; Agrafiotis, A.; Taft, J. M.; Yermanos, A.; Reddy, S. T.
10.1101/2025.05.01.651552 — immunology — Posted on 2025-05-02
5115 Brain Network Analysis in Alzheimer's Disease and Mild Cognitive Impairment using High-Density Diffuse Optical Tomography
Butters, E.; Collins-Jones, L.; Mesquita, R. C.; Acharya, D.; McKiernan, E.; Laurell, A. A.; Low, A.; Srinivasan, S.; O'Brien, J. T.; Su, L.; Bale, G.
10.1101/2025.04.28.651132 — neuroscience — Posted on 2025-05-02
5116 Mitochondrial dysfunction in Machado Joseph disease: insights from a multi-model system
Simo, I.; Robinson, K. J.; Kam, J.; Kuriakose, A.; Paric, E.; Cheng, F.; Potapenko, A.; An, Y.; Lee, A.; Laird, A. S.
10.1101/2025.05.01.651800 — neuroscience — Posted on 2025-05-02
5117 The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae
Yen, P.-S.; Verkuijl, S. A.; Capriotti, P.; Del Corsano, G.; Hoermann, A.; Inghilterra, M. G.; Aramburu-Gonzalez, I.; Kahn, M. A.; Christophides, G. K.; Vlachou, D.; Windbichler, N.
10.1101/2025.05.02.651860 — synthetic biology — Posted on 2025-05-02
5118 PBDE flame retardant exposure causes neurobehavioral and transcriptional effects in first-generation but not second-generation offspring fish
McNabb-Kelada, N.; Burke, T.; Jayaraman, S.; Mills, L.; De La Torre, A.; Francoeur, M.; Schraeder, H.; Nacci, D.; Clark, B.; Whitehead, A.
10.1101/2025.04.28.651134 — pharmacology and toxicology — Posted on 2025-05-02
5121 MAVISp: A Modular Structure-Based Framework for Protein Variant Effects
Arnaudi, M.; Beltrame, L.; Degn, K.; Utichi, M.; Scrima, S.; Sanchez-Izquierdo Besora, P.; Krzesinska, K.; Maselli, F.; Dorcakova, T.; Safer, J.; Estad, A. H.; Meldgard, K.; Becker, P.; Sora, V.; Pettenella, A.; Vinhas, J.; Bauer, L.; Saridaki, P.; Melidi, A.; Favaro, L.; Kiachaki, E.; Oswal, A.; Breitenstein, J.; Fas, B. A.; Tedeschi, G.; Sackett, P. W.; Cava, C.; Rohlin, A.; Nilbert, M.; Iqbal, S.; Lambrughi, M.; Tiberti, M.; Papaleo, E.
10.1101/2022.10.22.513328 — bioinformatics — Posted on 2025-05-02
5124 Structural basis of DNA recombination catalysis and regulation by phiC31 integrase
Sun, Y. E.; Aspinall, L. P.; Joseph, A. P.; Colloms, S. D.; Stark, M.; Spagnolo, L.
10.1101/2025.05.02.651858 — biochemistry — Posted on 2025-05-02
5125 Epithelial-Immune-Stromal Interactions Define Divergent Repair and Fibrosis Pathways After Acute Kidney Injury in Human Renal Transplants
Azim, S.; Rousselle, T.; Zubair, H.; Shetty, A. C.; Archer, K. J.; Marshall, J.; Rajabi, A.; Lara, C.; Mustofa, S.; Drachenberg, C.; Bromberg, J.; Menon, M.; Maluf, D. G.; Akalin, E.; Mas, V. R.
10.1101/2025.04.30.651080 — biochemistry — Posted on 2025-05-02
5126 Socially integrated female chimpanzees have lower offspring mortality
Feldblum, J. T.; Walker, K. K.; Stanton, M. A.; Lonsdorf, E. V.; Mjungu, D. C.; Murray, C. M.; Pusey, A. E.
10.1101/2025.04.29.651242 — animal behavior and cognition — Posted on 2025-05-02
5129 Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution
Ishida, T.; Mercoli, J. I.; Heck, A. M.; Phelps, I.; Varnum-Finney, B.; Dozono, S.; Nourigat-McKay, C.; Kraskouskas, K.; Wellington, R.; Waltner, O.; Jackson, D. L.; Delaney, C.; Rafii, S.; Bernstein, I. D.; Aldinger, K. A.; Trapnell, C.; Zhao, H. G.; Hadland, B.
10.1101/2023.06.01.543314 — developmental biology — Posted on 2025-05-02
5132 Auranofin Inhibits Hepatitis E Virus Replication Via Reactive Oxygen Species
Tiller, K.; Williams, S. T.; Wang, B.; Tian, D.; Meng, X.-J.; Weger-Lucarelli, J.
10.1101/2025.05.02.651833 — microbiology — Posted on 2025-05-02
5133 Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection
Joyce, L. R.; Akbari, M. S.; Nguyen, D. T.; Spencer, B. L.; McIver, K. S.; Horswill, A. R.; Doran, K. S.; Keogh, R. A.
10.1101/2025.05.02.651901 — microbiology — Posted on 2025-05-02
5134 Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus
Di Genova, C.; Warren, C. J.; Johnson, S.; Riccio, S.; Roper, K.; Thomas, S. S.; Schlachter, A.-L.; Jorge, D.; Ralh, K.; Hassan, J.; Billington, E.; Brown, I. H.; Slomka, M. J.; Banyard, A. C.; James, J.
10.1101/2025.05.02.651910 — microbiology — Posted on 2025-05-02
5137 Exploring C1 substrate cofeeding in Eubacterium limosum with AneVO, a low-cost anaerobic parallel bioreactor platform
Hoyt, K. O.; Zhou, G.; Gasparrini, W.; Sliter, P. J.; Hart, D. J.; Khalil, A. S.; Woolston, B. M.
10.1101/2025.05.02.651948 — microbiology — Posted on 2025-05-02
5138 Modeling epithelial and endothelial cell tropism for SARS-CoV-2 through restricted transgenic hACE2 expression in mice
Lameire, S.; Debeuf, N.; Deckers, J.; De Wolf, C.; Vanheerswynghels, M.; Toussaint, W.; De Vlieger, L.; Van Hoecke, L.; De Cae, S.; Schepens, B.; Vanhee, S.; Lambrecht, B. N.
10.1101/2025.05.01.651662 — immunology — Posted on 2025-05-02
5139 Lymph nodes link sex-biased immune aging to compromised antigen recognition
Menzel, L.; Zschummel, M.; O'Melia, M. J.; Zhou, H.; Lei, P.-J.; Liu, L.; Sen, D. R.; Munn, L. L.; Padera, T. P.
10.1101/2025.02.11.637693 — immunology — Posted on 2025-05-02
5143 Expression and Characterization of SARS-CoV-2 Spike Protein in Thermothelomyces heterothallica C1
Ophir, Y.; Wong, J.; Haddad, K. R.; Huuskonen, A.; Karmaker, A.; Gore, V.; Jung, S.; Oloumi, A.; Liu, Y.; Fu, J.; Zhang, L.; Huang, P.; Minami, S. A.; Garimella, S. S.; Thyagatur, A.; Zaini, P. A.; Vitikainen, M.; Tchelet, R.; Valbuena, N.; Fuerst, T.; Korkmaz, E.; Falo, L. D.; Balmert, S. C.; Mahendiratta, S.; Emalfarb, M.; Shah, P.; Siegel, J. B.; Dandekar, A. M.; Chen, X.; Lebrilla, C. B.; Faller, R.; Saloheimo, M.; McDonald, K. A.; Nandi, S.
10.1101/2025.05.01.651343 — bioengineering — Posted on 2025-05-02
5145 A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome
Harada, R.; Nishimura, Y.; Nomura, M.; Yabuki, A.; Shiba, K.; Inaba, K.; Inagaki, Y.; Nakayama, T.
10.1101/2025.05.02.651781 — evolutionary biology — Posted on 2025-05-02
5147 Escherichia coli with a 57-codon genetic code
Robertson, W. E.; Rehm, F. B. H.; Spinck, M.; Schumann, R. L.; Tian, R.; Liu, W.; Gu, Y.; Kleefeldt, A. A.; Day, C. F.; Liu, K. C.; Christova, Y.; Zurcher, J. F.; Boege, F. L.; Birnbaum, J.; van Bijsterveldt, L.; Chin, J. W.
10.1101/2025.05.02.651837 — synthetic biology — Posted on 2025-05-02
5148 Bounding phenotype transition probabilities via conditional complexity
Dingle, K.; Hagolani, P.; Zimm, R.; Umar, M.; O'Sullivan, S.; Louis, A.
10.1101/2024.12.18.629197 — biophysics — Posted on 2025-05-02
5149 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction
Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.
10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-05-02
5150 Chromatix: a differentiable, GPU-accelerated wave-optics library
Deb, D.; Both, G.-J.; Bezzam, E.; Kohli, A.; Yang, S.; Chaware, A.; Allier, C.; Cai, C.; Anderberg, G.; Eybposh, M. H.; Schneider, M. C.; Heintzmann, R.; Rivera-Sanchez, F. A.; Simmerer, C.; Meng, G.; Tormes-Vaquerano, J.; Han, S.; Shanmugavel, S. C.; Maruvada, T.; Yang, X.; Kim, Y.; Diederich, B.; Joo, C.; Waller, L.; Durr, N. J.; Pegard, N. C.; La Riviere, P. J.; Horstmeyer, R.; Chowdhury, S.; Turaga, S. C.
10.1101/2025.04.29.651152 — bioinformatics — Posted on 2025-05-02
5151 Evolutionary Sequence and Structural Basis for the Epistatic Origins of Drug Resistance in HIV
Biswas, A.; Choudhuri, I.; Huang, K.; Sun, Q.; Sali, A.; Echeverria, I.; Haldane, A.; Levy, R.; Lyumkis, D.
10.1101/2025.04.30.651576 — biophysics — Posted on 2025-05-02
5152 A high-throughput platform for biophysical antibody developability assessment to enable AI/ML model training
Arsiwala, A.; Bhatt, R.; Yang, Y.; Quintero Cadena, P.; Anderson, K.; Ao, X.; van Niekerk, L.; Rosenbaum, A.; Bhatt, A.; Smith, A.; Grippo, L.; Cao, X.; Cohen, R.; Patel, J.; Allen, O.; Faraj, A.; Nandy, A.; Hocking, J.; Tural, B.; Salvador, S.; Jacobowitz, J.; Schaven, K.; Sherman, M.; Shah, S.; Tessier, P. M.; Borhani, D.
10.1101/2025.05.01.651684 — biophysics — Posted on 2025-05-02
5154 Alpha-Synuclein Fibril Structures Cluster into Distinct Classes
Milchberg, M. H.; Warmuth, O. A.; Borcik, C. G.; Dhavale, D. D.; Wright, E. R.; Kotzbauer, P. T.; Rienstra, C. M.
10.1101/2025.04.30.651534 — biophysics — Posted on 2025-05-02
5158 H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves
Souza, C. K.; Santos, J. J. S.; Boggiatto, P.; Sterle, H.; Arruda, B.; Palmer, M. V.; Campos, A.; Liu, J.; Ye, N.; Weissman, D.; Hensley, S. E.; Baker, A. L.
10.1101/2025.05.01.651548 — microbiology — Posted on 2025-05-02
5161 Predation by a ciliate community mediates temperature and nutrient effects on a peatland prey prokaryotic community.
DeWitt, K.; Carrell, A.; Rocca, J.; Votzke, S.; Yammine, A.; Peralta, A. L.; Weston, D. J.; Pelletier, D. A.; Gibert, J. P.
10.1101/2024.04.05.588366 — ecology — Posted on 2025-05-02
5167 Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions
Snyder, L. F.; O'Brien, E. M.; Zhao, J.; Liang, J.; Bruce, B. J.; Zhang, Y.; Zhu, W.; Cassier, T.; Schnicker, N. J.; Zhou, X.; Gordan, R.; He, B. Z.
10.1101/2024.04.20.590343 — evolutionary biology — Posted on 2025-05-02
5168 Tracing the Spread of Celtic Languages using Ancient Genomics
McColl, H.; Kroonen, G.; Pinotti, T.; Barrie, W.; Koch, J.; Ling, J.; Demoule, J.-P.; Kristiansen, K.; Sikora, M.; Willerslev, E.
10.1101/2025.02.28.640770 — evolutionary biology — Posted on 2025-05-02
5170 CD24 regulates the formation of ectosomes in B lymphocytes
Phan, H. D.; Squires, W. R. B.; Mayne, K. E.; Kelly, G. R.; Jafardoust, R.; Christian, S. L.
10.1101/2024.08.14.607772 — cell biology — Posted on 2025-05-02
5171 Single-cell multiomics identifies both shared and unique features of immune dysfunction in the colon, plasma and stool from individuals diagnosed with Parkinson's disease or inflammatory bowel disease
Bolen, M. L.; buendia, m.; Shi, J.; Staley, H.; Kachergus, J. M.; Efron, P. A.; Park, G.; Nagpal, R.; Xue, Q.-S.; McFarland, N. R.; Zimmermann, E. M.; Forsmark, C. E.; Menees, K. B.; Salas, A.; Thompson, E. A.; Tansey, M. G.
10.1101/2025.04.29.651228 — neuroscience — Posted on 2025-05-02
5174 Functionality of potato virus Y coat protein in cell-to-cell movement is defined by flexibility of its N terminal region
Vozelj, A.; Povalej, T. M.; Stare, K.; Znidaric, M. T.; Bacnik, K.; Levak, V.; Aguirre, I. G.; Podobnik, M.; Gruden, K.; Coll, A.; Lukan, T.
10.1101/2025.04.29.651159 — plant biology — Posted on 2025-05-02
5175 Chemokinesis by a microbial predator
Quick, S. R.; Bains, J.; Gerdt, C.; Walker, B.; Goldstone, E. B.; Jakuszeit, T.; Baggaley, A. W.; Croze, O. A.; Gerdt, J. P.
10.1101/2025.05.01.651543 — biochemistry — Posted on 2025-05-02
5176 An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA
Palla, A. M.; Lin, C.-C.; Trnka, M. J.; Leao, E. M.; Petronikolou, N.; Burlingame, A. L.; McGinty, R. K.; Fujimori, D. G.
10.1101/2025.05.01.651538 — biochemistry — Posted on 2025-05-02
5178 Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry
Lee, A. S.; Fisher, N. P.; Marunde, M. R.; Su, P.; Khan, L. F.; Graham, B.; Taylor, H. F.; Onuoha, U. C.; Su, T.; Jooss, K.; Schachner, L. F.; Fuchs, H. A.; Noll, K.; Cheek, M. A.; Burg, J. M.; Sun, Z.-W.; Musselman, C. A.; Keogh, M. A.; Kelleher, N. L.
10.1101/2025.05.01.651740 — biochemistry — Posted on 2025-05-02
5181 Targeting Lysosomal Dysfunction to Alleviate Plaque Deposition in an Alzheimer Disease Model
Fremuth, L. E.; van de Vlekkert, D.; Hu, H.; Weesner, J. A.; Annunziata, I.; d'Azzo, A.
10.1101/2025.04.28.651121 — neuroscience — Posted on 2025-05-02
5182 Design of combination therapeutics from protein response to drugs in ovarian cancer cells
Franz, A.; Shen, C.; Coscia, F.; Munroe, K.; Charaoui, L.; Korkut, A.; Mann, M.; Luna, A.; Sander, C.
10.1101/2025.04.28.651139 — cancer biology — Posted on 2025-05-02
5185 Genetic architecture and cellular basis of flag leaf size variation in barley
Lapasiya, T.; Gao, Y.; Wu, P.-Y.; Haweit, A.; van Inghelandt, D.; Stich, B.; Shrestha, A.
10.1101/2025.04.28.650967 — genetics — Posted on 2025-05-02
5186 Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
Ragusa, D.; Suen, C. W.; Torregrosa Cortes, G.; Pastorino, F.; Johns, A.; Ciciro, Y.; Dijkhuis, L.; van den Brink, S.; Cilli, M.; Byrne, C.; Ionescu, G.-A.; Cerveira, J.; Kranc, K. R.; Hernandez-Hernandez, V.; Ponzoni, M.; Bigas, A.; Garcia-Ojalvo, J.; Martinez Arias, A.; Pina, C.
10.1101/2022.10.07.511362 — developmental biology — Posted on 2025-05-02
5187 VEGF counteracts shear stress-determined arterial fate specification during capillary remodeling.
Chen, D.; Rukhlenko, O. S.; Joshi, D.; Rudnicki, M.; Coon, B. G.; Chakraborty, R.; Tuliakova, A.; Ioannou, E.; Martin, K. A.; Ruhrberg, C.; Kholodenko, B. N.; Schwartz, M. A.; Simons, M.
10.1101/2024.01.23.576920 — developmental biology — Posted on 2025-05-02
5190 All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex
Frisby, S. L.; Halai, A. D.; Cox, C. R.; Clarke, A.; Shimotake, A.; Kikuchi, T.; Kuneida, T.; Arakawa, Y.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Rogers, T. T.; Lambon Ralph, M. A.
10.1101/2025.04.17.649404 — neuroscience — Posted on 2025-05-02
5193 NNMT is a biomarker of prostate cancer cells with a mesenchymal phenotype and induces sensitivity to metabolic agents
Carreira, A. S. A.; Ciuffreda, M.; Thongon, N.; Haughey, C. M.; Pickard, A.; Eddie, S. L.; Steele, R. E.; Cerri, E.; Belli, R.; Peroni, D.; Facen, E.; Caffa, I.; Ghanem, M.; Nencioni, A.; Lunardi, A.; Tebaldi, T.; Mills, I.; Provenzani, A.
10.1101/2025.04.29.651153 — cancer biology — Posted on 2025-05-02
5198 Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta.
Gruner, H. N.; Pickett, C. J.; Bao, J. Y.; Garcia, R.; Hozumi, A.; Scully, T.; Ning, S.; Gao, M.; Bautista, G.; Maze, K.; Lim, K.; Osugi, T.; Collins-Doijode, M.; Cairns, O.; Levis, G.; Chen, S. Y.; Gong, T.; Satake, H.; Moshe-Klein, A.; Gigante, E. D.; Sasakura, Y.; Davidson, B.
10.1101/2025.04.28.651085 — developmental biology — Posted on 2025-05-02
5199 Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, OvMANE1: preclinical evaluation in mice model
Nebangwa, D. N.; Efeti, M. T.; Momnougui, S. M. E.; Shintouo, C. M.; Shey, R. A.; Ntie-Kang, F.; Ayiseh, R. B.; Ghogomu, S. M.
10.1101/2025.04.28.651093 — immunology — Posted on 2025-05-02
5202 Mesenchymal WNT2B is Required for the Development and Function of the Human Intestine
Singh, A.; Poling, H. M.; Foulke-Abel, J.; Sundaram, N.; Al Reza, A.; Joseph, S.; Elseht, A.; Srivasta, K.; Krutko, M.; Mayhew, C. N.; Breault, D.; Wells, J. M.; Thiagarajah, J. R.; O'Connell, A. E.; Kovbasnjuk, O.; Helmrath, M. A.
10.1101/2025.05.01.651727 — developmental biology — Posted on 2025-05-02
5203 Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I
Leng, H.; jiang, j.; Gassner, K.; Midha, S.; Justo-Mendez, R.; Zheng, J.; Hall, T.; Luo, L.; West, S. D.; Vincent, T. L.; Wann, A.; Patel, K. A.; Poulton, J.; O'Callaghan, C. A.; Lechuga-Vieco, A. V.; Simon, A. K.
10.1101/2025.05.02.651799 — cell biology — Posted on 2025-05-02
5204 An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer
Xie, W.; Yu, X.; Yang, Q.; Ke, N.; Wang, P.; Kong, H.; Wu, X.; Ma, P.; Chen, L.; Yang, J.; Feng, X.; Wang, Y.; Shi, H.; Chen, L.; Liu, Y.-H.; Ding, B.-S.; Wei, Q.; Jiang, H.
10.1101/2024.11.19.624405 — immunology — Posted on 2025-05-02
5205 Targeted plasma proteomics uncover novel proteins associated with KIF5A-linked SPG10 and ALS spectrum disorders
Dulski, J.; Boddapati, A.; Risi, B.; Iruzubieta, P.; Orlacchio, A.; Fernandez Torron, R.; Castillo Trivino, T.; Lopez De M Arregui, A.; Vucic, S.; Kaat, L. D.; Barakat, T. S.; Petrucelli, L.; Prudencio, M.; Landers, J. E.; Prokop, A.; Weishaupt, J. H.; Filosto, M.; Wszolek, Z. K.; Pant, D. C.
10.1101/2025.04.29.651203 — neuroscience — Posted on 2025-05-02
5207 The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation
D'Aloisio, L. D.; Ballal, M.; Ghosh, S.; Haskey, N.; Abulizi, N.; Karimianghadim, R.; Liu, C.; Sruthi, P.; Nagarajan, L.; Vasudevan, S.; Shetty, V.; Purandare, M.; Bhaumik, U.; Howlader, D. R.; Pakpour, S.; Barnett, J.; Gibson, D. L.
10.1101/2024.03.04.582285 — microbiology — Posted on 2025-05-02
5213 Functional and Structural Characterization of F1-ATPase with common ancestral core domains in stator ring
Suzuki, A. K.; Furukawa, R.; Sobti, M.; Brown, S. H. J.; Stewart, A. G.; Akanuma, S.; Ueno, H.; Noji, H.
10.1101/2025.04.30.651372 — biophysics — Posted on 2025-05-02
5216 A functionally validated TCR-pMHC database for TCR specificity model development
Messemaker, M.; Kwee, B. P. Y.; Moravec, Z.; Alvarez-Salmoral, D.; Urbanus, J.; de Paauw, S.; Geerligs, J.; Voogd, R.; Morris, B.; Guislain, A.; Mussmann, M.; Winkler, Y.; Steinmetz, M.; Iras, M.; Marcus, E.; Teuwen, J.; Perrakis, A.; Beijersbergen, R. L.; Scheper, W.; Schumacher, T.
10.1101/2025.04.28.651095 — immunology — Posted on 2025-05-02
5217 Regulation of B cell tolerance and autoimmunity by miR-130b
Herrero-Fernandez, B.; Gonzalez-Molina, M. d. P.; Gamez-Reche, L.; Prieto-Munoz, A. M.; Sanz, J.; Gonzalo, T.; Moreno, A.; Lopez-Molina, M.; Manas, L.; Nemazee, D.; Xiao, C.; Otero-Ortega, L.; Gonzalez-Martin, A.
10.1101/2025.01.22.634242 — immunology — Posted on 2025-05-02
5218 Self-Organizing Neural Networks in Organoids Reveal Principles of Forebrain Circuit Assembly
Hernandez, S.; Schweiger, H. E.; Cline, I.; Kaurala, G. A.; Robbins, A.; Solis, D.; Geng, J.; van der Molen, T.; Reyes, F.; Asogwa, C. N.; Voitiuk, K.; Chini, M.; Rolandi, M.; Salama, S. R.; Colquitt, B. M.; Sharf, T.; Haussler, D.; Teodorescu, M.; Mostajo-Radji, M. A.
10.1101/2025.05.01.651773 — neuroscience — Posted on 2025-05-02
5221 An open, fully-processed data resource for studying mood and sleep variability in the developing brain
Brook, J. B. H.; Salo, T.; Luo, A. C.; Bagautdinova, J.; Rush, S.; Alexander-Bloch, A. F.; Baller, E. B.; Calkins, M. E.; Cieslak, M.; Cooper, E. C.; Detre, J. A.; Elliot, M. A.; Fair, D. A.; Freedman, P.; Gehrman, P. R.; Gur, R. C.; Gur, R. E.; Klein, A.; Laney, N.; Laumann, T. O.; Mehta, K.; Merikangas, K.; Milham, M. P.; Mitchell, J. A.; Moore, T. M.; Nelson, S. M.; Ruparel, K.; Sevchik, B. L.; Shanmugan, S.; Shou, H.; Taso, M.; White, L. K.; Wolf, D. H.; Tisdall, D.; Roalf, D. R.; Satterthwaite, T. D.
10.1101/2025.05.01.651544 — neuroscience — Posted on 2025-05-02
5222 Network Neuroscience of Human Multitasking: Local Features Matter
Mueckstein, M.; Hilger, K.; Heinzel, S.; Granacher, U.; Rapp, M. A.; Stelzel, C.
10.1101/2025.04.30.651494 — neuroscience — Posted on 2025-05-02
5226 Is Britain still Great for Pine Marten? A Habitat Suitability Assessment
Lewis, E.; Swinnerton, K.; Fitzmaurice, A.; Armour-Chelu, N.; Gardner, R.; Ball, L.
10.1101/2025.03.19.643030 — zoology — Posted on 2025-05-02
5227 Insulin/insulin-like growth factor signaling pathway promotes higher fat storage in Drosophila females
Biswas, P.; Bako, J. A.; Liston, J. B.; Yu, H.; Wat, L. W.; Miller, C. J.; Gordon, M. D.; Huan, T.; Stanley, M.; Rideout, E. J.
10.1101/2024.11.18.623936 — physiology — Posted on 2025-05-02
5229 Structural basis for no retinal binding in flotillin-associated rhodopsins
Kovalev, K.; Stetsenko, A.; Trunk, F.; Marin, E.; Haro-Moreno, J. M.; Lamm, G. H. U.; Alekseev, A.; Rodriguez-Valera, F.; Schneider, T. R.; Wachtveitl, J.; Guskov, A.
10.1101/2025.04.29.651185 — biophysics — Posted on 2025-05-02
5231 Glycan Atlassing: Nanoscale analysis of glycocalyx architecture enables functional tracing of cell state
Joseph, D. M.; Yurekli, N.; Fritsche, S.; Hashem, R.; Thoma, O.-M.; Larafa, I.; Boric, T.; Bielawski, C.; Almahayni, K.; Franze, K.; Waldner, M. J.; Moeckl, L.
10.1101/2025.04.29.651200 — biophysics — Posted on 2025-05-02
5232 Recognizing amino acid sidechains in a medium resolution cryo-electron density map
Mondal, D.; Kumar, V.; Satler, T.; Ramachandran, R.; Saltzberg, D.; Chemmama, I.; Pilla, K. B.; Echeverria, I.; Webb, B. M.; Gupta, M.; Verba, K. A.; Sali, A.
10.1101/2024.12.10.627859 — biophysics — Posted on 2025-05-02
5233 Inflammasome Activation in Cutaneous Squamous Cell Carcinoma
Patel, K. R.; Shu, R. R.; Wang, R.; Tekale, K.; Hamersky, M.; Perez, A. B.; Solano, D.; Syed, N.; Stewart, C. E.; Lee, J.; Hanlon, A. M.; Blalock, T. W.; Li, C.; Seldin, L.
10.1101/2025.04.29.650608 — cell biology — Posted on 2025-05-02
5234 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in hepatocellular carcinoma
Xu, S.; Gong, R.; Liu, S.; Wang, J.; Shen, Y.; Peng, C.; Feng, Q.; Luo, M.; Lan, F.; Fan, J.; Cai, J.; Lan, X.
10.1101/2025.05.01.651793 — cell biology — Posted on 2025-05-02
5235 Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice
Asokaumar, A.; Mathur, B.; Chou, A.; Cronologia, B.; Alencastro, F.; Wheeler, L.; Mathews, C. K.; Moore, D. D.; Duncan, A. W.; Anakk, S.
10.1101/2025.04.29.651109 — cell biology — Posted on 2025-05-02
5238 Temporal Dynamics of Azot Expression Following Traumatic Brain Injury.
Gutierrez-Garcia, A.; Marques-Reis, M.; Hauert, B.; Lampaya, E. M.
10.1101/2025.04.29.651334 — cell biology — Posted on 2025-05-02
5241 MARK4 enhances stress granule formation and increases tau accumulation
Nakajima, S.; Sultanakhmetov, G.; Fukuchi, A.; Watanabe, K.; Ito, K.; Shimizu, S.; Asada, A.; Saito, T.; Ando, K.
10.1101/2025.04.30.651577 — cell biology — Posted on 2025-05-02
5243 Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation
Juliani, J.; Tran, S.; Harris, T. J.; Ellis, S. L.; Al-Ani, A. H.; Patel, K. M.; Young, S. N.; Evangelista, M.; Baloyan, D.; Reehorst, C. M.; Nightingale, R.; Jenkins, L. J.; De Cruz, P.; Duszyc, K.; Kile, B. T.; Yap, A. S.; Mariadason, J. M.; Christensen, B.; Samson, A. L.; Murphy, J. M.; Fairlie, W. D.; Lee, E. F.
10.1101/2025.04.29.651340 — cell biology — Posted on 2025-05-02
5244 LHR and Gαs trafficking drive sustained cAMP signalling from endosomes to control steroidogenesis
Gourdon, J.; Haj-Hassan, M.; Jugnarain, V.; Gauthier, C.; Alves, S.; Guillou, F.; Reiter, E.; Jean-Alphonse, F.
10.1101/2025.04.30.651471 — cell biology — Posted on 2025-05-02
5248 GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells
Deng, C.; Elujoba-Bridenstine, A.; Song, A. T.; Ceplina, R. M.; Ostheimer, C. J.; Hahn, M. C. P.; Scarlett, C. O.; Tamplin, O. J.
10.1101/2025.04.30.651482 — cell biology — Posted on 2025-05-02
5250 ATPγS unbiases kinesin
Karnawat, V.; Toleikis, A.; Molloy, J.; Carter, N.; Cross, R. A.
10.1101/2025.05.01.651652 — biophysics — Posted on 2025-05-01
5251 Cyclin A2 Induces Human Adult Cardiomyocyte Cytokinesis and Elicits Cardiomyocyte Reprogramming and Dedifferentiation
Bouhamida, E.; Vadakke-Madathil, S.; Mathiyalagan, P.; Ranjan, A.; Khan, A.; Sherman, C.; Miller, P. E.; Ghetti, A.; Abi-Gerges, N.; Chaudhry, H. W.
10.1101/2024.03.01.583057 — cell biology — Posted on 2025-05-01
5253 Safety and Efficacy of a Novel Glycoengineered Recombinant Vaccine Candidate against Haemonchus contortus in Sheep
Sajovitz-Grohmann, F.; Adduci, I.; Werling, D.; Wiedermann, S.; Wortha, L. N.; Prole, B.; Zloebl, J.; Elster, J.; Tichy, A.; Joachim, A.; Wittek, T.; Hinney, B.; Yan, S.; Lichtmannsperger, K.
10.1101/2025.04.30.651318 — molecular biology — Posted on 2025-05-01
5254 Daily light exposure habits of youth with migraine: A prospective pilot study
Gentile, C. P.; Shah, R.; Marquez de Prado, B.; Raj, N.; Szperka, C. L.; Hershey, A. D.; Aguirre, G. K.
10.1101/2025.04.30.650986 — neuroscience — Posted on 2025-05-01
5256 Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort
Sim, M. A.; Rowsthorn, E.; O'Brien, W. T.; Sun, M.; Cribb, L.; Franks, K.; McDonald, S. J.; Yiallourou, S.; Cavuoto, M.; Harding, I. H.; Chong, T. T.-J.; Law, M.; O'Brien, T. J.; Vivash, L.; Pase, M.
10.1101/2025.04.30.651583 — neuroscience — Posted on 2025-05-01
5257 The China Brain Multi-omics Atlas Project (CBMAP)
Zhou, D.; Zhou, Y.; Sun, Z.; Ji, F.; Zhang, D.; Wang, Q.; Ruan, Y.; Wang, Y.; Zhu, Y.; Sun, X.; Li, M. J.; Yuan, C.; Liu, K.; Sun, L.; Zhai, W.; Fan, J.; Zhu, K.; Qiu, W.; Yan, X.; Ma, C.; Shen, Y.; Bao, A.; Yue, W.; Shi, Y.; Chen, C.; Yang, J.; Duan, S.; Zhang, J.
10.1101/2025.04.30.651445 — neuroscience — Posted on 2025-05-01
5258 Custom-Built Electrodes Perform Comparably to a Discontinued Commercial Electrode for Neuromuscular Electrical Stimulation in Mice
Odeh, B. H.; Wellman, A. L.; Ameye, M.; Atwood, Z.; Gray, L.; Saravanan, A.; Poluru, H.; Begam, M.; Jones, T. I.; Roche, R.; Roche, J. A.
10.1101/2025.04.30.651500 — physiology — Posted on 2025-05-01
5260 Integrative multi-omics modelling for cultivated meat production, quality, and safety
Mathieu, T.; Legare, S.; Nzekoue, A. F.; Jaure, N.; Lester, H.; Dias, T.; Kusters, R.
10.1101/2025.04.30.651459 — bioinformatics — Posted on 2025-05-01
5262 Does reduced reactivity explain altered postural control in Parkinson's disease? A predictive simulation study.
Shanbhag, J.; Fleischmann, S.; Wechsler, I.; Gassner, H.; Winkler, J.; Eskofier, B. M.; Koelewijn, A. D.; Wartzack, S.; Miehling, J.
10.1101/2025.04.30.651447 — bioengineering — Posted on 2025-05-01
5264 Spatial patterns of diversity in forest birds of peninsular India
Goyal, N.; Sharma, A.; Jagati, V.; Herur, A.; Jain, A.; Gopal, A.; Joshi, J.; Robin, V. V.
10.1101/2025.04.28.650994 — ecology — Posted on 2025-05-01
5266 A multipotent cell type from the term human placenta
Vadakke-Madathil, S.; Bouhamida, E.; Wang, B.; Mathiyalagan, P.; Ayyamperumal, P.; Khan, A.; Oniskey, M.; Santos-Gallego, C.; Hadley, M.; Croft, L.; Dekio, F.; Brody, R.; Gelber, S.; Sperling, R.; Chaudhry, H. W.
10.1101/2023.08.02.551028 — cell biology — Posted on 2025-05-01
5267 Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Culviner, P. H.; Frey, A. M.; Liu, Q. H.; Ha, D. T. M.; Thai, P. V. K.; Thu, D. D. A.; Quang, N. L.; Calderon, R.; Lecca, L.; Caws, M.; Dunstan, S. J.; Murray, M. B.; Thuong, N. T. T.; Fortune, S. M.
10.1101/2025.05.01.651750 — microbiology — Posted on 2025-05-01
5268 EEG Functional Connectivity as a Marker of Evolution from Infantile Epileptic Spasms Syndrome to Lennox-Gastaut Syndrome
Mila, B. R.; Liu, V. B.; Smith, R. J.; Hu, D. K.; Benneian, N. A.; Hussain, S. A.; Steenari, M.; Phillips, D.; Adams, D.; Skora, C.; Lopour, B. A.; Shrey, D. W.
10.1101/2025.04.30.650531 — neuroscience — Posted on 2025-05-01
5269 Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism
Brisset, M.; Radkova, K.; Paradisi, A.; Stephan, L.; Wagner, R.; Degletagne, C.; Luiggi, F.; Frydman, L.; Heriot, A.; Behrenbruch, C.; Vu, T.; Mehlen, P.; Hollande, F.
10.1101/2025.04.28.650943 — cancer biology — Posted on 2025-05-01
5272 Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR
Guzman, B. B.; Goda, G. A.; Jimenez, A.; Martyr, J. G.; Hu, Y.; Cavazos, F. F.; Aleman, M. M.; Dominguez, D.
10.1101/2025.05.01.651718 — biochemistry — Posted on 2025-05-01
5273 Classification of outcomes in antimalarial therapeutic efficacy studies with Aster
Gerlovina, I.; Berube, S.; Briggs, J.; Murie, K.; Murphy, M.; Wesolowski, A.; Greenhouse, B.
10.1101/2025.04.28.651146 — genetics — Posted on 2025-05-01
5275 Overcoming lentiviral delivery limitations in hard-to-transduce suspension cells for genome-wide CRISPR screening
Napoleone, A.; Sebastian, I. R.; De Marco, F.; Molin, A. K.; Hussein, M.; Kramer, L.; Jostock, T.; Kelly, T.; Borth, N.
10.1101/2025.05.01.651049 — molecular biology — Posted on 2025-05-01
5277 Diversity and prevalence of Anaerostipes in the human gut microbiota
Bhattacharjee, D.; Millman, L. C.; Seesengood, M. L.; Seekatz, A. M.
10.1101/2025.05.01.651700 — microbiology — Posted on 2025-05-01
5279 H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves
Souza, C. K.; Santos, J. J. S.; Boggiatto, P.; Sterle, H.; Arruda, B.; Palmer, M. V.; Campos, A.; Liu, J.; Ye, N.; Weissman, D.; Hensley, S. E.; Vincent Baker, A. L.
10.1101/2025.05.01.651548 — microbiology — Posted on 2025-05-01
5280 Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
Yabaji, S. M.; Zhernovkov, V.; Araveti, P. B.; Lata, S.; Rukhlenko, O. S.; Abdullatif, S. A.; Vanvalkenburg, A.; Alekseev, Y.; Ma, Q.; Dayama, G.; Lau, N. C.; Johnson, W. E.; Bishai, W. R.; Crossland, N. A.; Campbell, J. D.; Kholodenko, B. N.; Gimelbrant, A. A.; Kobzik, L.; Kramnik, I.
10.1101/2024.03.05.583602 — immunology — Posted on 2025-05-01
5281 Intratumoral amino acid insufficiency limits CD8+ T-cell effector function
Chen, Y.-T.; Lin, Y.-H.; Rahman, J.; Cross, J.; Pavlova, N. N.; Vardhana, S. A.
10.1101/2025.04.28.651077 — immunology — Posted on 2025-05-01
5282 A functionally validated TCR-pMHC database for TCR specificity model development
Messemaker, M.; Kwee, B. P. Y.; Moravec, Z.; Alvarez-Salmoral, D.; Urbanus, J.; de Paauw, S.; Geerligs, J.; Voogd, R.; Morris, B.; Guislain, A.; Mussmann, M.; Winkler, Y.; Steinmetz, M.; Iras, M.; Marcus, E.; Teuwen, J.; Perrakis, A.; Beijersbergen, R. L.; Scheper, W.; Schumacher, T.
10.1101/2025.04.28.651095 — immunology — Posted on 2025-05-01
5283 Nanophysiology Approach Reveals Diversity in Calcium Microdomains across Zebrafish Retinal Bipolar Ribbon Synapses
Rameshkumar, N.; Shrestha, A. P.; Boff, J. M.; Hoon, M.; Matveev, V.; Zenisek, D.; Vaithianathan, T.
10.1101/2024.11.01.617078 — neuroscience — Posted on 2025-05-01
5286 Low level of viral intra-host diversity is associated with severe SFTS disease
Wei, X.; Li, H.; Sai, L.; Song, L.; Gao, X.; Li, C.; Zhang, X.; Shen, Y.; Li, S.; Liu, L.; Golubchik, T.; Xu, Y.
10.1101/2025.04.28.650738 — pathology — Posted on 2025-05-01
5289 Boundary-guided cell alignment drives mouse epiblast maturation
Ichikawa, T.; Guruciaga, P. C.; Hu, S.; Plunder, S.; Makino, M.; Hamaji, M.; Stokkermans, A.; Yoshida, S.; Erzberger, A.; Hiiragi, T.
10.1101/2025.04.28.650859 — developmental biology — Posted on 2025-05-01
5290 A kinetic ruler controls mRNA poly(A) tail length
Gabs, E.; Aalto-Setala, E.; Valisaari, A.; Malinen, A. M.; Heick Jensen, T.; McLaughlin, S. H.; Passmore, L. A.; Turtola, M.
10.1101/2025.05.01.651612 — molecular biology — Posted on 2025-05-01
5292 Isolation and Characterization of Salt Tolerant Soil Bacteria from Selected Locations in the West Coast of Sri Lanka.
Senarath, N. G. L. C.; Edirisinghe, R.; Senarath-Yapa, M. D.; Hemachandra, I. P. A.; Somaratne, Y.; Jayawardana, N. U.
10.1101/2025.05.01.651645 — microbiology — Posted on 2025-05-01
5293 Efficient packaging of HIV-1 genomes via recognition of its adenosine-rich content by a heterologous RNA-binding domain
Vuong, H. R.; Zhou, Q.; Lesko, S.; Tenneti, K.; Davis, K.; Scott, S.; Boodwa-Ko, D.; Eschbach, J. E.; Gopal, K.; Porter, J.; Wang, Y.; Mohammed, S.; Lee, N.; Telesnitsky, A.; Sherer, N. M.; Kutluay, S. B.
10.1101/2025.05.01.651415 — microbiology — Posted on 2025-05-01
5298 Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1
Guo, C.; Yu, Y.; Liu, J.; Jian, F.; Yang, S.; Song, W.; Shao, F.; Yu, L.; Cao, Y.
10.1101/2025.04.30.651462 — immunology — Posted on 2025-05-01
5300 Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.
Weir, K.; Lyu, P.; Kandoi, S.; An, R.; Pannullo, N.; Palazzo, I.; Tangeman, J.; Shi, J.; DeVries, S.; Merriman, D.; Qian, J.; Blackshaw, S.
10.1101/2025.04.25.650540 — neuroscience — Posted on 2025-05-01
5301 Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers
Santander, T.; Bekir, S.; Paul, T.; Simonson, J. M.; Wiemer, V. M.; Skinner, H. E.; Hopf, J. L.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.
10.1101/2025.02.14.638327 — neuroscience — Posted on 2025-05-01
5302 MrHAMER2: high-accuracy long-read RNA sequencing to decode isoform-specific variation in viral transcripts during latency
Gallardo, C. M.; Albert, J. L.; Qazi, A. A.; Ventura, R. L.; Deshmukh, S.; Beliakova-Bethell, N.; Torbett, B. E.
10.1101/2024.12.19.629526 — genomics — Posted on 2025-05-01
5303 Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity
Soon, M. S.; Oyong, D. A.; Dooley, N.; Mukhiya, R.; Pava, Z.; Andrew, D.; Loughland, J. R.; McCarthy, J.; Chan, J.-A.; Beeson, J. G.; Engwerda, C.; Haque, A.; Boyle, M. J.
10.1101/2025.02.27.640479 — immunology — Posted on 2025-05-01
5307 Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium
Wolfson, D.; Hull, J.; Li, Y.; Gonzalez, T.; Jayaram, M.; Devlin, G.; Cigliola, V.; Oonk, K.; Rosales, A.; Bursac, N.; Asokan, A.; Poss, K. D.
10.1101/2025.04.28.651096 — developmental biology — Posted on 2025-05-01
5308 Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue
Duarte Afonso Serdan, T.; Frank, B.; Cervantes, H.; Gargey, A.; Tian, Q.; Hope, D.; Choi, C. H. J.; Hoffmann, A.; Cohen, P.; Bluher, M.; Aydin, H.; Schwartz, G. J.; Shamsi, F.
10.1101/2024.09.24.613949 — cell biology — Posted on 2025-05-01
5310 Mice dynamically adapt to opponents in competitive multi-player games
Erlich, J. C.; Rastogi, M.; Yin, Q.; Orsolic, I.; Cruz, B. F.; Almeida, A.; Duan, C. A.
10.1101/2025.02.14.638359 — neuroscience — Posted on 2025-05-01
5311 Regulatory logic of human cortex evolution by combinatorial perturbations
Skaros, A.; Vitriolo, A.; Leonardi, O.; Finazzi, V.; Pereira, M. F.; Prazzoli, F.; Trattaro, S.; Moriano, J.; Capocefalo, D.; Villa, C. E.; Boettcher, M.; Boeckx, C.; Testa, G.
10.1101/2025.04.28.651083 — systems biology — Posted on 2025-05-01
5312 PertEval-scFM: Benchmarking Single-Cell Foundation Models for Perturbation Effect Prediction
Wenteler, A.; Occhetta, M.; Branson, N.; Huebner, M.; Curean, V.; Dee, W.; Connell, W.; Hawkins-Hooker, A.; Chung, P.; Ektefaie, Y.; Valdez Cordova, C. M.; Gallagher-Syed, A.
10.1101/2024.10.02.616248 — bioinformatics — Posted on 2025-05-01
5315 iSHARC: Integrating scMultiome data for heterogeneity and regulatory analysis in cancer
Zeng, Y.; Bahl, S.; Xu, X.; Ci, X.; Keshavarzian, T.; Yang, L.; Lee, H. S.; Kossinna, P.; Gaiti, F.; Schwartz, G. W.; He, H. H.; Lupien, M.
10.1101/2025.04.28.651068 — bioinformatics — Posted on 2025-05-01
5316 OmiXAI: An Ensemble XAI Pipeline for Interpretable Deep Learning in Omics Data
Alaeva, A.; Lapteva, A.; Mikhaylovskaya, N.; Malkov, V.; Herbert, A.; Borevskiy, A.; Poptsova, M.
10.1101/2025.04.28.651097 — bioinformatics — Posted on 2025-05-01
5317 Subconcussive preconditioning prevents microglial morphology changes and improves cognitive outcomes in mice
Anderson, E. D.; Kim, K.; Georges, A. P.; Naveen, A.; Grajales, E.; Augustin, D. V.; Meaney, D. F.
10.1101/2025.04.28.651064 — bioengineering — Posted on 2025-05-01
5318 The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CODIGO): building local capacity in genomics, bioinformatics, and precision medicine
Marino-Ramirez, L.; Sharma, S.; Hamilton, J. M.; Nguyen, T. L.; Gupta, S.; Natarajan, A. V.; Nagar, S. D.; Menuey, J. L.; Chen, W.-A.; Sanchez-Gomez, A.; Satizabal-Soto, J. M.; Martinez, B.; Marrugo, J.; Medina-Rivas, M.; Gallo, J. E.; Jordan, I. K.; Valderrama-Aguirre, A.
10.1101/2025.04.28.651081 — genomics — Posted on 2025-05-01
5320 Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers
Stephanou, A.; Mantri, M.; Shankaranarayanan, D.; Li, C.; Lagman, M.; Xiang, J. Z.; Pan, C.; Sun, Y.; Muthukumar, T.; Machaca, K.; de vlaminck, i.; Suthanthiran, M.
10.1101/2025.04.28.651042 — immunology — Posted on 2025-05-01
5322 Information-making processes in the speaker's brain drive human conversations forward
Goldstein, A.; Wang, H.; Sheffer, T.; Schain, M.; Zada, Z.; Niekerken, L.; Aubrey, B.; Nastase, S. A.; Gazula, H.; Casto, C.; Doyle, W. K.; Friedman, D.; Devore, S.; Dugan, P.; Hassidim, A.; Brenner, M.; Matias, Y.; Devinsky, O.; Flinker, A.; Hasson, U.
10.1101/2024.08.27.609946 — neuroscience — Posted on 2025-05-01
5326 Integrin-TGFb axis induces partial EMT in basal-like cells to lead collective invasion
El-Gammal, A.; Jansen, L.; Verhagen, M. P.; Kremer, H.; Soufi, S.; Masoudnia, M.; Da Silva, I.; Westland, D.; Bult, P.; Fodde, R.; Verstegen, M. M. A.; Gloerich, M.; van Mil, S. W. C.; Khalil, A. A.
10.1101/2025.04.04.647177 — cell biology — Posted on 2025-05-01
5328 Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene
Wells, A. T.; Bossardi Ramos, R.; Shen, M. M.; Binrouf, R. H.; D'Amico, A. E.; Lennartz, M. R.
10.1101/2024.12.09.627650 — immunology — Posted on 2025-05-01
5330 A Novel Model for Proton Transport Mediated by Uncoupling Protein 1
Jacobsen, L.; Menon, S.; Gaudry, M. J.; Hakami Zanjani, A. A.; Reinholdt, P.; Jastroch, M.; Khandelia, H.
10.1101/2025.04.28.650983 — biophysics — Posted on 2025-05-01
5337 B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response
Xin, X.; Demircik, F.; Antipova, M.; Stylianakis, E.; Klein, M.; Bejarano, D. A.; Elwy, A.; Ebering, A.; Blanfeld, M.; Carter, K.; Johann, L.; Uhlfelder, D.; Blickberndt, E.; Probst, H. C.; Hoevelmeyer, N.; Bopp, T.; Arens, R.; den Haan, J. M.; Gommerman, J.; von Stebut, E.; Clausen, B.; Schlitzer, A.; Lang, K. S.; Becker, R. A.; Lemmermann, N.; Waisman, A.
10.1101/2025.04.28.651045 — immunology — Posted on 2025-05-01
5338 Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling
Tetenborg, S.; Shihabeddin, E.; Kumar, E. O. A. M.; Sigulinsky, C.; Dedek, K.; Lin, Y.-P.; Echeverry, F.; Hoff, H.; Pereda, A.; Jones, B. W.; Ribelayga, C.; Ebnet, K.; Matsuura, K.; O'Brien, J.
10.1101/2024.11.26.625481 — neuroscience — Posted on 2025-05-01
5339 HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling
Wang, L.; Xing, p.; Zhao, X.; Song, X.; Wei, M.; Lei, L.; Xu, R.; Wang, R.; Ma, L.; You, D.; Chen, P.; Xie, M.; Zhao, M.; Zhang, H.; Lv, H.; Li, A.; Wang, X.; Gao, S.; Chen, X.
10.1101/2024.03.02.583089 — cancer biology — Posted on 2025-05-01
5346 A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
Sawhney, A. S.; Deskin, B. J.; Cai, J.; Gibbard, D.; Ali, G.; Utoft, A.; Olson, A.; Hausman, H.; Sabol, L.; Holmberg, S.; Shah, R.; Warren, R.; De Langhe, S. P. J.; Benedito, R.; Inde, Z.; Sarosiek, K.; Lemire, E.; Haber, A. L.; Wang, L.; Wei, Z.; Brownfield, D. G.
10.1101/2025.04.28.650846 — developmental biology — Posted on 2025-05-01
5347 Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation
Klein, R.; Onyuru, J.; Centa, J. L.; Viera, E. M.; Duelli, F. J.; Putnam, C. D.; Hoffman, H. M.; Hastings, M. L.
10.1101/2024.09.06.611206 — molecular biology — Posted on 2025-05-01
5352 A Fundamental Approach to Buoyant Density Determination by DGE-AUC
Yarawsky, A. E.; Cardenas Lopez, P.; Walter, J.; DeLion, M. T.; Paul, L. N.
10.1101/2025.04.28.650698 — biophysics — Posted on 2025-05-01
5353 SquiDBase: a community resource of raw nanopore data from microbes
Cuypers, W. L.; Ceylan, H.; Turcksin, E.; Raes, L.; de Vrij, N.; Michiels, J.; Coppens, S.; de Block, T.; Jansen, D.; Arien, K. K.; Selhorst, P.; Vercauteren, K.; Gauglitz, J. M.; Bittremieux, W.; Laukens, K.
10.1101/2025.04.28.650941 — bioinformatics — Posted on 2025-05-01
5354 Variant Classification Using Proteomics-Informed Large Language Models Increases Power of Rare Variant Association Studies and Enhances Target Discovery
Gillies, C. E.; Mbatchou, J.; Habegger, L.; Kessler, M. D.; Bao, S.; Balasubramanian, S.; Delaneau, O.; Kosmicki, J. A.; Regeneron Genetics Center, ; Willer, C. J.; Kang, H. M.; Baras, A.; Reid, J.; Marchini, J.; Abecasis, G. R.; Ghoussaini, M.
10.1101/2025.04.28.650692 — bioinformatics — Posted on 2025-05-01
5355 Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters
Sakhnini, L. I.; Beltrame, L.; Fulle, S.; Sormanni, P.; Henriksen, A.; Lorenzen, N.; Vendruscolo, M.; Granata, D.
10.1101/2025.04.28.650927 — bioinformatics — Posted on 2025-05-01
5358 Influence of simplifications on FE modelling of mandible and TMJ implants
Chandra, G.; Verma, V.; Ghosh, R.; Kaur, K.; Roychoudhury, A.; Mukherjee, S.; Chawla, A.; Mukherjee, K.
10.1101/2025.04.28.651047 — bioengineering — Posted on 2025-05-01
5360 Genetic architecture and cellular basis of flag leaf size variation in barley
Lapasiya, T.; Gao, Y.; Wu, P.-Y.; Haweit, A.; van Inghelandt, D.; Stich, B.; Shrestha, A.
10.1101/2025.04.28.650967 — genetics — Posted on 2025-05-01
5361 Biting time of day in malaria mosquitoes is modulated by nutritional status
Oke, C. E.; Rund, S. S. C.; Machani, M. G.; Sabtiu, A. R. M.; Akuamoah-Boateng, Y.; Afrane, Y. A.; Reece, S. E.
10.1101/2025.04.28.650966 — ecology — Posted on 2025-05-01
5363 Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver inflammation and hepatic fibrosis in mice
Eswaran, S.; Gebert, L.; Schraven, S.; Treichel, N. S.; Ritz, T.; Hamm, S.; Seeger, A.; Kiessling, F.; Clavel, T.; Wagner, N.; Schippers, A.
10.1101/2025.04.28.650968 — immunology — Posted on 2025-05-01
5368 Stretchable, hair-compatible, and long-term stable wearable EEG system
Hsieh, J.-C.; Yao, M.; Alawieh, H.; Koptelova, V.; Kumar, S.; Tang, K. K. W.; Wang, W.; Jeong, J.; Ding, H.; Chae, T.; Ahmad, Z.; Wang, D.; Engrav, T.; Wang, R.; Gupta, A.; He, W.; Moscoso-Barrera, W. D.; Grimes, A.; Millan, J. d. R.; Wang, H.
10.1101/2025.04.28.651043 — bioengineering — Posted on 2025-05-01
5372 Computational modeling-directed combination treatment with etanercept and mifepristone mitigates neuroinflammation in a mouse model of Gulf War Illness.
Kelly, K. A.; Felton, C. M.; Billig, B. K.; Yilmaz, A. A.; OCallaghan, J. P.; Craddock, T. J. A.; Broderick, G.; Klimas, N.; Michalovicz, L. T.
10.1101/2025.04.30.651399 — neuroscience — Posted on 2025-05-01
5374 INFLAMMATORY ACTIVATION, EPIGENETIC SIGNATURE AND MORPHO-STRUCTURAL ALTERATION IN A COHORT OF PATIENTS WITH CHRONIC HEART FAILURE AND PERMANENT ATRIAL FIBRILLATION: A CROSS-SECTIONAL STUDY.
Daidone, M.; Maida, C. D.; Pacinella, G.; Ferrantelli, S.; Scaglione, S.; todaro, f.; Pipitone, R.; lupo, g.; agnello, l.; Ciaccio, M.; Armentaro, G.; Sciacqua, A.; Di Chiara, T.; Di Raimondo, D.; GRIMAUDO, S.; Casuccio, A.; Tuttolomondo, A.
10.1101/2025.04.29.651356 — scientific communication and education — Posted on 2025-05-01
5376 Discovery of a new evolutionarily conserved short linear F-actin binding motif
Paraschiakos, T.; Yuan, B.; Sopelniak, K.; Bucher, M.; Simon, L.; Zonjic, K.; Eggers, D.; Selle, F.; Li, J.; Linder, S.; Marlovits, T. C.; Windhorst, S.
10.1101/2025.04.16.649135 — biochemistry — Posted on 2025-05-01
5377 Separating direct, indirect and parent-of-origin genetic effects in the human population
Kraetschmer, I.; Hegemann, L. E.; Hofmeister, R.; Corfield, E. C.; Mahmoud, S. M.; Delaneau, O.; Andreassen, O. A.; Campbell, A.; Hayward, C.; Estonian Biobank Research Team, ; Marioni, R. E.; Ystrom, E.; Havdahl, A.; Robinson, M. R.
10.1101/2025.04.28.650988 — genetics — Posted on 2025-05-01
5379 Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA
Gamas, K. R.; Seamons, T.; Dysart, M.; Fang, L.; Chappell, J.; Stadler, L.; Silberg, J.
10.1101/2025.04.29.651329 — synthetic biology — Posted on 2025-05-01
5380 Parallel evolution of full-length genomes in a long-term evolution experiment with phage ΦX174
Bons, E.; Chabas, H.; MacDonald, H.; Escalera Ledermann, A.; Ochsner, N.; Angst, D. C.; Bonhoeffer, S.; Regoes, R. R.
10.1101/2025.04.22.649699 — evolutionary biology — Posted on 2025-05-01
5381 Recurrent Mutations Drive the Rapid Evolution of Pesticide Resistance in the Two-spotted Spider Mite Tetranychus urticae
Cao, L.-J.; Chen, J.-C.; Thai, J.; Schmidt, T.; Ffrench-Constant, R.; Zhang, L.-X.; Yang, Y.; Yuan, M.-C.; Zhang, J.-Y.; Zhang, X.-Y.; Yang, Q.; Gong, Y.-J.; Li, H.; Chen, X.; Hoffmann, A.; Wei, S.-J.
10.1101/2025.02.06.636798 — evolutionary biology — Posted on 2025-05-01
5382 TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming
Zhu, W.; Xu, X.; Nagarajan, V.; Guo, J.; Pent, Z.; Zhang, A.; Liu, J.; Mattapallil, M. J.; Jittayasothorn, E.; Constantinides, M.; Horai, R.; Belkaid, Y.; St. Leger, A. J.; Caspi, R.
10.1101/2024.04.01.587519 — immunology — Posted on 2025-05-01
5385 Small pangenome of Candida parapsilosis reflects overall low intraspecific diversity
Ryan, A.; Bergin, S. A.; Scully, J.; Zuniga-Soto, E.; Hession, C.; Barber, A. E.; Gomez-Molero, E.; Bader, O.; Morio, F.; Zhai, B.; Wolfe, K. H.; Butler, G.
10.1101/2025.04.30.651475 — genomics — Posted on 2025-05-01
5386 Clade-wide proteome analysis shows widespread non-canonical Dcr proteins in fungi.
Melet, L.; Canan, J.; Villalobos, P.; Vidal-Veuthey, B.; Gonzalez-Toro, F.; Orellana, I.; Rivas-Pardo, J. A.; Cardenas, J. P.; Moraga, C.; Castro-Fernandez, V.; Johnson, N. R.; Vidal, E. A.
10.1101/2025.04.28.651110 — genomics — Posted on 2025-05-01
5388 Speed Matters: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli
Ali, K. M.; Murphy, R.; Zanchi, C.; Zunk-Parras, S. A.; Rodriguez-Rojas, A.; Rolff, J.
10.1101/2025.04.25.650648 — evolutionary biology — Posted on 2025-05-01
5389 Parallel clines of chromosomal inversion in seaweed flies associated with thermal variation
Nicolas, L. A.; Berdan, E. L.; Colinet, H.; Clouard, A.; De Wit, P.; Glemin, S.; Merot, C.
10.1101/2025.04.28.650981 — evolutionary biology — Posted on 2025-05-01
5390 Single-cell analyses reveal scyphozoan conserved and specific genes contribution during tissue regeneration in two jellyfish
Li, Y.; Law, S. T. S.; Nong, W.; So, W. L.; Xie, Y.; Leung, T. C. N.; Li, T. H.; Tse, J.; Yip, H. Y.; Jin, O.; Zhang, J.; Chui, A. P.; Lau, K. F.; John, A.; Kai, Z. p.; Bendena, W. G.; Hayward, A.; Wei, Y.; Chan, T. F.; Ngai, S. M.; Hui, J. H. L.
10.1101/2025.04.29.650939 — evolutionary biology — Posted on 2025-05-01
5394 Optimizing Antimicrobial Susceptibility Testing: Cost and Environmental Benefits of MIC Volume Reduction
Clarhaut, J. A.; Moreau, J.; Collet, T.; Babiard, E.; Aranzana-Climent, V.; Marchand, S.; Brunet, K.; Buyck, J. M.
10.1101/2025.04.29.651209 — microbiology — Posted on 2025-05-01
5395 TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation
Thomas, S. M.; McGee, A. P.; Vielma, T. E.; Ankley, L. M.; Rapp, A. W.; Conner, K. N.; LeSage, F.; Tanner, C. D.; Scheeres, E. C.; Obar, J. J.; Olive, A. J.
10.1101/2024.09.04.611226 — immunology — Posted on 2025-05-01
5396 Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease
Zvyagina, V.; Kuriakose, A.; Simo, I.; Kam, J. Y.; Chakraborty, P.; Robinson, K. J.; Potapenko, A.; Watchon, M.; Paulsen, I. T.; Gamage, H. K. A. H.; Laird, A. S.
10.1101/2025.04.30.651362 — neuroscience — Posted on 2025-05-01
5397 Pathological α-Synuclein Perturbs Nuclear Integrity
Millett, M. F.; Comite, A.; Martin Castosa, E.; Heuberger, A.; Wagner, P.; Gallardo, I.; Reinhardt, J.; Chambers, N.; Hall, D.; Miller, E.; Nabert, D.; Balsamo, B.; Prokop, S.; Moehle, M.
10.1101/2025.03.04.641384 — neuroscience — Posted on 2025-05-01
5398 Accurate and fast segmentation of filaments and membranes in micrographs and tomograms with TARDIS
Kiewisz, R.; Fabig, G.; Conway, W.; Johnston, J.; Kostyuchenko, V.; Tan, A.; Barinka, C.; Clarke, O. B.; Magaj, M.; Yazdkhasti, H.; Vallese, F.; Lok, S.-m.; Redemann, S.; Muller-Reichert, T.; Bepler, T.
10.1101/2024.12.19.629196 — bioinformatics — Posted on 2025-05-01
5400 Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate
Borar, P.; Biswas, T.; Chaudhuri, A.; Rao, P. T.; Raychaudhuri, S.; Huxford, T.; Chakrabarti, S.; Ghosh, G.; Polley, S.
10.1101/2023.06.27.546692 — biochemistry — Posted on 2025-05-01
5402 Two telomere-to-telomere genome assemblies and comparisons revealed the conserved key genes associated with sugar accumulation in Rubus genus
Li, X.; Han, X.; Liu, S.; Zhang, Q.; Guan, J.; Tang, Y.; Zhang, M.; Xu, P.; Zheng, M.; Bian, J.; Li, K.; Sun, G.; Sun, Y.; Dong, Y.; Lin, X.; Wang, Z.; Zhou, H.; Yang, G.; Liu, Z.; Lian, H.; He, H.; Zhou, J.
10.1101/2025.04.09.646780 — genomics — Posted on 2025-05-01
5403 GSK-3β coordinates axonal microtubule organisation through Shot and Tau
Voelzmann, A.; Nuhu-Soso, L.; Roof, A.; Patel, S.; Bennett, H.; Adamson, A. D.; Bentley, M.; Evans, G. J. O.; Hahn, I.
10.1101/2024.09.08.611864 — cell biology — Posted on 2025-05-01
5404 Defining the ordered pathway for ZAP-mediated RNA decay
Bouton, C. R.; Gimpelj Domjanic, G.; Lista, M. J.; Galao, R. P.; Courty, T.; Wilson, H. D.; Hill, P. W. S.; Mischo, H. E.; Chakrabarti, A. M.; Poljak, M.; Ule, J.; Neil, S. J. D.; Swanson, C. M.
10.1101/2025.04.28.650959 — immunology — Posted on 2025-05-01
5406 PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and Tamoxifen in a luminal A breast cancer model
Schwarzmueller, L.; Mueller, J.; Vlachavas, E.-I.; Beumers, L.; Fleischhacker, L.; Burmester, S.; Helm, D.; Koerner, C.; Wiemann, S.
10.1101/2025.04.28.651009 — cancer biology — Posted on 2025-05-01
5409 Buying time - increasing yield potential in wheat by extending stem elongation duration
Kronenberg, L.; Gonzalez-Navarro, O. E.; Collier, S.; Chhetry, M.; Tailby, P.; Leverington-Waite, M.; Wingen, L. U.; Griffiths, S.
10.1101/2025.04.28.650957 — genetics — Posted on 2025-05-01
5410 Neurogliaform cells mediate interhemispheric modulation of sensory-evoked activity in cortical pyramidal neurons
Markopoulos, F.; Chrereau, R.; Brandalise, F.; Chippalkatti, V.; Prados, J.; Dayer, A.; Holtmaat, A.
10.1101/2025.04.30.651595 — neuroscience — Posted on 2025-05-01
5415 Tbr2-Dependent Parallel Pathways Regulate the Development of Distinct ipRGC Subtypes
Kiyama, T.; Chen, C.-K.; Altay, H. Y.; Chen, Y.-J.; Sigala, L.; Su, D.; Eliason, S. L.; Amendt, B.; Mao, C.-A.
10.1101/2025.04.29.651262 — developmental biology — Posted on 2025-05-01
5418 HPDL is critical in human cortical development via regulation of mitochondrial functional properties
Baggiani, M.; Desbats, M. A.; Naef, V.; Giacich, M.; Galatolo, D.; Mero, S.; Zampieri, S.; Cappello, V.; Valentino, A.; Salviati, L.; Santorelli, F. M.; Damiani, D.
10.1101/2025.04.28.651017 — neuroscience — Posted on 2025-05-01
5420 PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour
Novelli, L.; Stoliker, D.; Barta, T.; Greaves, M. D.; Chopra, S.; Jackson, J.; Kwee, J.; Williams, M.; Razi, A.
10.1101/2025.04.11.643415 — neuroscience — Posted on 2025-05-01
5421 Cross-species Standardised Cortico-Subcortical Tractography
Assimopoulos, S.; Warrington, S.; Folloni, D.; Bryant, K.; Tang, W.; Jbabdi, S.; Heilbronner, S.; Mars, R. B.; Sotiropoulos, S. N.
10.1101/2025.04.29.651254 — neuroscience — Posted on 2025-05-01
5422 Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP
Kirk, L. M.; Garcia, G. C.; Zatyko, K.; Bartol, T. M.; Sejnowski, T. J.; Harris, K. M.
10.1101/2025.04.29.651313 — neuroscience — Posted on 2025-05-01
5423 3D multimodal histological atlas and coordinate framework for the mouse brain and head
Tward, D. J.; Flannery, P. J.; Savoia, S.; Mezias, C.; Banerjee, S.; Richman, M.; Lodato, B.; O'Rourke, J. R.; Balani, S.; Arima, K.; Washington, S.; Coronado-Leija, R.; Zhang, J.; Mitra, P. P.
10.1101/2025.04.30.650246 — neuroscience — Posted on 2025-05-01
5426 Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer
Ahmad, F.; White, M.; Yamamoto, K.; Crooks, D. R.; Agarwal, S.; Yang, Y.; Capaldo, B.; Raj, S.; Alilin, A. N.; Ton, A.; Adler, S.; Seidel, J.; Olkowski, C.; Cherukuri, M. K.; Choyke, P. L.; Kelly, K.; Brender, J. R.
10.1101/2023.11.15.567250 — cancer biology — Posted on 2025-05-01