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Archive, 2021-11

4 Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Pelech, S.; Gallagher, C.; Sutter, C.; Yue, L.; Kerwin, J.; Bhargava, A.; Iorns, E.; Tsui, R.; Denis, A.; Perfito, N.; Errington, T. M.
10.1101/2021.11.30.470372 — cancer biology — Posted on 2021-11-30
6 Development of PRPK Directed Phthalimides
Seo, H.-S.; Mizutani, T.; Hideshima, T.; Vangos, N. E.; Zhang, T.; Anderson, K. C.; Gray, N. S.; Dhe-Paganon, S.
10.1101/2021.11.30.469594 — biochemistry — Posted on 2021-11-30
8 A shape-shifting nuclease unravels structured RNA
Meze, K.; Axhemi, A.; Thomas, D. R.; Doymaz, A.; Joshua-Tor, L.
10.1101/2021.11.30.470623 — biochemistry — Posted on 2021-11-30
9 Rolling Circle RNA Synthesis Catalysed by RNA
Kristoffersen, E. L.; Burman, M.; Noy, A.; Holliger, P.
10.1101/2021.11.30.470609 — biochemistry — Posted on 2021-11-30
12 Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling
Agajanian, M. J.; Potjewyd, F. M.; Bowman, B. M.; Solomon, S.; LaPak, K. M.; Bhatt, D. P.; Smith, J. L.; Goldfarb, D.; Axtman, A. D.; Major, M. B.
10.1101/2021.11.30.470617 — cell biology — Posted on 2021-11-30
14 RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cells
Shi, P.; Murphy, M. R.; Aparicio, A. O.; Kesner, J. S.; Fang, Z.; Chen, Z.; Trehan, A.; Wu, X.
10.1101/2021.11.30.470032 — molecular biology — Posted on 2021-11-30
16 TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
Nore, A.; Juarez-Martinez, A. B.; Clement, J. A.; Brun, C.; Diagouraga, B.; Grey, C.; Bourbon, H.-M.; Kadlec, J.; Robert, T.; de Massy, B.
10.1101/2021.11.30.470517 — molecular biology — Posted on 2021-11-30
17 Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution
Liakopoulos, A.; Aulin, L. B. S.; Buffoni, M.; Fragkiskou, E.; van Hasselt, J. G. C.; Rozen, D. E.
10.1101/2020.10.19.345058 — microbiology — Posted on 2021-11-30
19 The Atypical Antipsychotic Quetiapine Induces Multiple Antibiotic Resistance in Escherichia coli
Kyono, Y.; Ellezian, L.; Hu, Y.; Eliadis, K.; Moy, J.; Hirsch, E. B.; Federle, M. J.; Flowers, S.
10.1101/2021.11.29.470511 — microbiology — Posted on 2021-11-30
20 Plasmodiophora brassicae in Mexico, from anecdote to fact
Padron-Rodriguez, L.; Cerdan Cabrera, C. R.; Sanchez Coello, N. G.; Luna-Rodriguez, M.; Perez-Lopez, E.
10.1101/2021.11.29.469274 — microbiology — Posted on 2021-11-30
24 A bistable orthogonal prokaryotic differentiation system underlying development of conjugative transfer competence
Sulser, S.; Vucicevic, A.; Bellini, V.; Moritz, R.; Delavat, F.; Sentchilo, V.; Carraro, N.; van der Meer, J. R.
10.1101/2021.11.30.470536 — microbiology — Posted on 2021-11-30
25 Site-specificity of streptococci in the oral microbiome
McLean, A. R.; Torres-Morales, J.; Borisy, G. G.; Mark Welch, J. L.
10.1101/2021.11.29.470446 — microbiology — Posted on 2021-11-30
27 SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
Bartolo, L.; Afroz, S.; Pan, Y.-G.; Xu, R.; Williams, L.; Lin, C.-F.; Friedman, E. S.; Gimotty, P. A.; Wu, G. D.; Su, L.
10.1101/2021.11.29.470421 — immunology — Posted on 2021-11-30
28 Forearm and hand muscles exhibit high coactivation and overlapping of cortical motor representations
Pazin Tardelli, G.; Souza, V. H.; Hiroshi Matsuda, R.; Cavalcanti Garcia, M. A.; Novikov, P.; Nazarova, M.; Baffa, O.
10.1101/2021.07.20.453121 — neuroscience — Posted on 2021-11-30
29 Latent functional connectivity underlying multiple brain states
McCormick, E. M.; Arnemann, K. L.; Ito, T.; Hanson, S. J.; Cole, M. W.
10.1101/2021.04.05.438534 — neuroscience — Posted on 2021-11-30
31 Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance
Zephyr, J.; Rao, D. N.; Vo, S. V.; Henes, M.; Kosovrasti, K.; Matthew, A. N.; Hedger, A. K.; Timm, J.; Chan, E. T.; Ali, A.; Yilmaz, N. K.; Schiffer, C. A.
10.1101/2021.11.30.470632 — biochemistry — Posted on 2021-11-30
32 Structural characterization of a MAPR-related archaeal cytochrome b5M protein
Teakel, S.; Marama, M.; Aragao, D.; Tsimbalyuk, S.; Forwood, J. K.; Cahill, M. A.
10.1101/2021.11.30.470528 — biochemistry — Posted on 2021-11-30
34 OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
Sturm, G.; Karan, K. R.; Monzel, A.; Santhanham, B. S.; Taivassalo, T.; Bris, C.; Duplaga, S. A.; Cross, M.; Towheed, A.; Higgins-Chen, A.; McManus, M. J.; Cardenas, A.; Lin, J.; Epel, E. S.; Rahman, S.; Vissing, J.; Grassi, B.; Levine, M.; Horvath, S.; Haller, R. G.; Lenaers, G.; Wallace, D. C.; Tavazoie, S.; Procaccio, V.; Kaufman, B. A.; Seifert, E. L.; Hirano, M.; Picard, M.
10.1101/2021.11.29.470428 — cell biology — Posted on 2021-11-30
36 The processing of staphylococcal biofilm images from Fluorescence and Confocal Microscopy to assess in vitro efficacy of antiseptic molecules
Junka, A. F.; Krasowski, G.; Migdal, P.; Woroszylo, M.; Fijalkowski, K.; Chodaczek, G.; Czajkowska, J.; Dudek, B.; Nowicka, J.; Oleksy, M.; Kwiek, B.; Paleczny, J.; Brozyna, M.
10.1101/2021.11.30.470646 — microbiology — Posted on 2021-11-30
39 Heterologous Vaccination with SARS-CoV-2 Spike saRNA Prime followed by DNA Dual-Antigen Boost Induces Robust Antibody and T-Cell Immunogenicity against both Wild Type and Delta Spike as well as Nucleocapsid Antigens
Rice, A.; Verma, M.; Voigt, E.; Battisti, P.; Beaver, S.; Reed, S.; Dinkins, K.; Mody, S.; Zakin, L.; Sieling, P.; Tanaka, S.; Morimoto, B.; Higashide, W.; Olson, C. A.; Gabitzsch, E. R.; Safrit, J. T.; Spilman, P. R.; Casper, C.; Soon-Shiong, P.
10.1101/2021.11.29.470440 — immunology — Posted on 2021-11-30
40 A human monoclonal antibody potently pan-neutralizes SARS-CoV-2 VOCs by targeting RBD invariant sites
Wang, X.; Hu, A.; Chen, X.; Zhang, Y.; Yu, F.; Yue, S.; Li, A.; Zhang, J.; Pan, Z.; Yang, Y.; Lin, Y.; Gao, L.; Zhou, J.; Zhao, J.; Li, F.; Shi, Y.; Huang, F.; Yang, X.; Peng, Y.; Tu, L.; Zhang, H.; Zheng, H.; He, J.; Zhang, H.; Xu, L.; Huang, Q.; Zhu, Y.; Deng, K.; Ye, L.
10.1101/2021.11.29.470356 — immunology — Posted on 2021-11-30
41 Peptide-antibody Fusions Engineered by Phage Display Exhibit Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants
Labriola, J. M.; Miersch, S.; Chen, G.; Chen, C.; Pavlenco, A.; Pisanu, F.; Caccuri, F.; Zani, A.; Sharma, N.; Feng, A.; Leung, D. W.; Caruso, A.; Amarasinghe, G. K.; Sidhu, S.
10.1101/2021.11.29.470362 — synthetic biology — Posted on 2021-11-30
45 General dimensions of human brain morphometry inferred from genome-wide association data
Fürtjes, A. E.; Arathimos, R.; Coleman, J. R.; Cole, J. H.; Cox, S. R.; Deary, I. J.; de la Fuente, J.; Madole, J. W.; Tucker-Drob, E. M.; Ritchie, S. J.
10.1101/2021.10.22.465437 — genetics — Posted on 2021-11-30
46 TFAP2 paralogs pioneer chromatin access for MITF and directly inhibit genes associated with cell migration
Kenny, C.; Dilshat, R.; Seberg, H.; Van Otterloo, E.; Bonde, G.; Helverson, A.; Steingrimsson, E.; Cornell, R. A.
10.1101/2021.11.23.469757 — developmental biology — Posted on 2021-11-30
47 Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
Glon, D.; Vilmen, G.; Perdiz, D.; Hernandez, E.; Beauclair, G.; QUIGNON, F.; Berlioz-Torrent, C.; Maréchal, V.; Poüs, C.; Lussignol, M.; Esclatine, A.
10.1101/2021.06.11.448012 — cell biology — Posted on 2021-11-30
48 A diencephalic circuit for opioid analgesia but not positive reinforcement
Waung, M. W.; Maanum, K. A.; Cirino, T. J.; Driscoll, J. R.; O'Brien, C.; Bryant, S.; Mansourian, K. A.; Morales, M.; Barker, D. J.; Margolis, E. B.
10.1101/2020.12.15.422931 — neuroscience — Posted on 2021-11-30
49 Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood
Khan, K.; Bierlein-De La Rosa, G.; Biggerstaff, N.; Pushpavathi, S. G.; Mason, S.; Dailey, M. E.; Marcinkiewcz, C.
10.1101/2021.11.29.469930 — neuroscience — Posted on 2021-11-30
54 Survey on Open Science Practices in Functional Neuroimaging
Paret, C.; Unverhau, N.; Feingold, F.; Poldrack, R. A.; Stirner, M.; Schmahl, C.; Sicorello, M.
10.1101/2021.11.26.470115 — scientific communication and education — Posted on 2021-11-30
56 Increased Brain Volumetric Measurement Precision from Multi-Site 3D T1-weighted 3T Magnetic Resonance Imaging by Correcting Geometric Distortions
Nanayakkara, N. D.; Arnott, S. R.; Scott, C. J. M.; Solovey, I.; Liang, S.; Fonov, V. S.; Gee, T.; Broberg, D. N.; Haddad, S. M. H.; Ramirez, J.; Berezuk, C.; Holmes, M.; Adamo, S.; Ozzoude, M.; Theyers, A.; Sujanthan, S.; Zamyadi, M.; Casaubon, L.; Dowlatshahi, D.; Mandzia, J.; Sahlas, D.; Saposnik, G.; Hassan, A.; Swartz, R. H.; Strother, S. C.; Szilagyi, G. M.; Black, S. E.; Symons, S.; ONDRI Investigators, ; Bartha, R.
10.1101/2021.11.29.469919 — bioengineering — Posted on 2021-11-30
59 Zika virus infection drives epigenetic modulation of immunity by the histone acetyltransferase CBP of Aedes aegypti
Amarante, A. d. M.; da Silva, I. C. d. A.; Vicentino, A. R. R.; Carneiro, V. C.; Pinto, M. d. A.; Higa, L. M.; Moharana, K. C.; da Cunha, O. A. T.; Venancio, T. M.; de Oliveira, P. L.; Fantappie, M. R.
10.1101/2021.10.22.463187 — molecular biology — Posted on 2021-11-30
60 A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in Toxoplasma gondii
Dominicus, C.; Nofal, S. D.; Broncel, M.; Kastris, N. J.; Flynn, H.; Arrizabalaga, G.; Botte, C. Y.; Invergo, B. M.; Treeck, M.
10.1101/2021.11.29.470317 — microbiology — Posted on 2021-11-30
62 Dynamic Domain Specificity In Human Ventral Temporal Cortex
Bankson, B. B.; Boring, M. J.; Richardson, R. M.; Ghuman, A. S.
10.1101/2020.11.11.378877 — neuroscience — Posted on 2021-11-30
63 TractoInferno: A large-scale, open-source, multi-site database for machine learning dMRI tractography
Poulin, P.; Theaud, G.; Rheault, F.; St-Onge, E.; Bore, A.; Renauld, E.; De Beaumont, L.; Guay, S.; Jodoin, P.-M.; Descoteaux, M.
10.1101/2021.11.29.470422 — neuroscience — Posted on 2021-11-30
65 Hypothermia Suppresses Uncoupling of Oxidative-Phosphorylation after Neonatal Cerebral Hypoxia-Ischemia
Sun, N.; Sun, Y.-Y.; Cao, R.; Chen, H.-R.; Wang, Y.; Fugate, E.; Smucker, M. R.; Kuo, Y.-M.; Grant, P. E.; Lindquist, D. M.; Kuan, C.-Y.; Hu, S.
10.1101/2021.11.29.470404 — neuroscience — Posted on 2021-11-30
67 Differential EDS1 requirement for cell death activities of plant TIR-domain proteins
Johanndrees, O.; Baggs, E.; Uhlmann, C.; Locci, F.; Laessle, H. L.; Melkonian, K.; Kaeufer, K.; Dongus, J. A.; Nakagami, H.; Krasileva, K. V.; Parker, J. E.; Lapin, D.
10.1101/2021.11.29.470438 — plant biology — Posted on 2021-11-30
69 sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs
Di Gioacchino, A.; Legendre, R.; Rahou, Y.; Najburg, V.; Charneau, P.; Greenbaum, B. D.; Tangy, F.; van der Werf, S.; Cocco, S.; Komarova, A. V.
10.1101/2021.11.30.470527 — bioinformatics — Posted on 2021-11-30
70 A Sparse Additive Model for High-Dimensional Interactions with an Exposure Variable
Bhatnagar, S. R.; Lu, T.; Lovato, A.; Olds, D. L.; Kobor, M. S.; Meaney, M. J.; O'Donnell, K.; Yang, Y.; Greenwood, C. M.
10.1101/445304 — bioinformatics — Posted on 2021-11-30
73 Restructuring of genomic provinces of surface ocean plankton under climate change
Fremont, P.; Gehlen, M.; Vrac, M.; Leconte, J.; Delmont, T.; Wincker, P.; Iudicone, D.; Jaillon, O.
10.1101/2020.10.20.347237 — ecology — Posted on 2021-11-30
74 Case Study of High-Throughput Drug Screening and Remote Data Collection for SARS-CoV-2 Main Protease by Using Serial Femtosecond X-ray Crystallography
Guven, O.; Gul, M.; Ayan, E.; Johnson, J. A.; Cakilkaya, B.; Usta, G.; Ertem, F. B.; Tokay, N.; Yuksel, B.; Gocenler, O.; Buyukdag, C.; Botha, S.; Ketawala, G.; Su, Z.; Hayes, B.; Poitevin, F.; Batyuk, A.; Yoon, C. H.; Kupitz, C.; Durdagi, S.; Sierra, R. G.; DeMirci, H.
10.1101/2021.11.28.468932 — molecular biology — Posted on 2021-11-30
75 Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Wang, L.; Kainulainen, M. H.; Jiang, N.; Di, H.; Bonenfant, G.; Mills, L.; Currier, M.; Shrivastava-Ranjan, P.; Calderon, B. M.; Sheth, M.; Mann, B. R.; Hossain, J.; Lin, X.; Lester, S.; Pusch, E.; Jones, J.; Cui, D.; Chatterjee, P.; Jenks, H. M.; Morantz, E.; Larson, G.; Hatta, M.; Harcourt, J.; Tamin, A.; Lin, Y.; Tao, Y.; Zhao, K.; Lacek, K.; Burroughs, A.; Wong, T.; Tong, S.; Barnes, J. R.; Tenforde, M. W.; Self, W. H.; Shapiro, N. I.; Exline, M. C.; Files, D. C.; Gibbs, K. W.; Hager, D. N.; Patel, M.; Laufer Halpin, A. S.; McMullan, L. K.; Lee, J. S.; Spiropoulou, C. F.; Thornburg, N. J.;
10.1101/2021.11.24.469906 — microbiology — Posted on 2021-11-30
76 Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality
Fears, A. C.; Beddingfield, B. J.; Chirichella, N. R.; Slisarenko, N.; Killeen, S. Z.; Redmann, R. K.; Goff, K.; Spencer, S.; Picou, B.; Golden, N.; Bush, D. J.; Branco, L. M.; Boisen, M. L.; Gao, H.; Montefiori, D.; Blair, R. V.; Doyle-Meyers, L. A.; Russel-Lodrigue, K. E.; Maness, N. J.; Roy, C. J.
10.1101/2021.11.28.470250 — microbiology — Posted on 2021-11-30
77 A recombinant SARS-CoV-2 RBD antigen expressed in insect cells elicits immunogenicity and confirms safety in animal models
Choque-Guevara, R.; Poma-Acevedo, A.; Montesinos-Millan, R.; Rios-Matos, D.; Gutierrez-Manchay, K.; Montalvan, A.; Quinones-Garcia, S.; Cauti-Mendoza, M. d. G.; Agurto-Arteaga, A.; Ramirez-Ortiz, I.; Criollo-Orozco, M.; Huaccachi-Gonzales, E.; Lazaro, Y. K. R.; Perez-Martinez, N.; Isasi-Rivas, G.; Sernaque-Aguilar, Y.; Villanueva-Perez, D.; Vallejos-Sanchez, K.; Fernandez-Sanchez, M.; Guevara, L.; Fernandez-Diaz, M.; Zimic, M.; COVID-19 Working Group in Peru,
10.1101/2021.11.26.470043 — immunology — Posted on 2021-11-30
78 COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis
Sinha, S.; Castillo, V.; Espinoza, C. R.; Tindle, C.; Fonseca, A. G.; Dan, J. M.; Katkar, G. D.; Das, S.; Sahoo, D.; Ghosh, P.
10.1101/2021.11.28.470269 — immunology — Posted on 2021-11-30
79 Localizing spontaneous memory reprocessing during human sleep
Himmer, L.; Bürger, Z.; Fresz, L.; Maschke, J.; Wagner, L.; Brodt, S.; Braun, C.; Schönauer, M.; Gais, S.
10.1101/2021.11.29.470230 — neuroscience — Posted on 2021-11-30
80 The HUSH complex controls brain architecture and protocadherin fidelity
Hagelkruys, A.; Horrer, M.; Taubenschmid-Stowers, J.; Kavirayani, A.; Novatchkova, M.; Orthofer, M.; Pai, T.-P.; Cikes, D.; Zhuk, S.; Balmana, M.; Esk, C.; Koglgruber, R.; Cronin, S. J.; Elling, U.; Knoblich, J. A.; Penninger, J. M.
10.1101/2021.11.29.466909 — neuroscience — Posted on 2021-11-30
83 Transposon Extermination Reveals Their Adaptive Fitness Contribution
Cranz-Mileva, S.; Reilly, E.; Chalhoub, N.; Patel, R.; Atanassova, T.; Cao, W.; Ellison, C.; Zaratiegui, M.
10.1101/2021.11.29.470382 — genomics — Posted on 2021-11-30
84 Epistasis is not a strong constraint on the recurrent evolution of toxin-resistant Na+,K+-ATPases among tetrapods
Mohammadi, S.; Yang, L.; Herrera-Alvarez, S.; Rodriguez-Ordonez, M. d. P.; Zhang, K.; Storz, J.; Dobler, S.; Crawford, A. J.; Andolfatto, P.
10.1101/2021.11.29.470343 — evolutionary biology — Posted on 2021-11-30
85 OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
Sturm, G.; Karan, K. R.; Santhanham, B. S.; Taivassalo, T.; Bris, C.; Duplaga, S. A.; Cross, M.; Towheed, A.; Higgins-Chen, A. T.; McManus, M. J.; Cardenas, A.; Lin, J.; Epel, E. S.; Rahman, S.; Vissing, J.; Grassi, B.; Levine, M.; Horvath, S.; Haller, R. G.; Lenaers, G.; Wallace, D. C.; Tavazoie, S.; Procaccio, V.; Kaufman, B. A.; Seifert, E.; Hirano, M.; Monzel, A.; Picard, M.
10.1101/2021.11.29.470428 — cell biology — Posted on 2021-11-30
86 TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma
Chakraborty, R.; Jabeen, A.; Hu, H.; Darido, C.; Vickery, K.; Ranganathan, S.
10.1101/2021.11.29.470496 — cell biology — Posted on 2021-11-30
90 Hepatocytes with a phenotype of substantial CYP3A4 induction generated from drug-associated fulminant hepatitis-derived induced pluripotent stem cells
Ite, K.; Toyoda, M.; Yoshioka, S.; Yukitake, T.; Yamazaki-Inoue, M.; Tatsumi, K.; Akutsu, H.; Nishina, H.; Kimura, T.; Ohtani, N.; Nakazawa, A.; Kasahara, M.; UMEZAWA, A.
10.1101/2021.11.30.470519 — cell biology — Posted on 2021-11-30
91 The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins
Cantero, G.; Burballa, C.; Ohkawa, Y.; Fukuda, T.; Harada, Y.; IBD Character Consortium, ; Curwin, A. J.; Brouwers, N.; Thun, G. A.; Gu, J.; Gut, I. G.; Malhotra, V.
10.1101/2021.11.30.469270 — cell biology — Posted on 2021-11-30
94 Structural and functional organization of visual responses in the inferior olive of larval zebrafish
Felix, R.; Markov, D. A.; Renninger, S. L.; Tomas, R.; Laborde, A.; Carey, M. R.; Orger, M. B.; Portugues, R.
10.1101/2021.11.29.470378 — neuroscience — Posted on 2021-11-30
96 KymoMerge: a new tool for analysis of multichannel kymographs
McMahon, L.; Digilio, L.; Duston, A.; Yap, C. C.; Winckler, B.
10.1101/2021.11.29.470387 — neuroscience — Posted on 2021-11-30
98 Representation of Drosophila larval behaviors by muscle activity patterns
Zhou, J.; Huang, Z.; Li, X.; Song, Z.; Sun, Y.; Ping, J.; Chen, X.; Fei, P.; Zheng, N.; Gong, Z.
10.1101/2021.11.26.470133 — neuroscience — Posted on 2021-11-30
100 Interactions of host defense and hyper-keratinization in psoriasis
Deng, J.; Leijten, E.; Nordkamp, M. O.; Sarita, H.; Tao, W.; Pouw, J.; Balak, D.; Rijken, R.; Huang, R.; Radstake, T.; Lu, C.; Pandit, A.
10.1101/2021.11.26.469424 — systems biology — Posted on 2021-11-30
101 A framework for multiplex imaging optimization and reproducible analysis
Eng, J. R.; Bucher, E.; Hu, Z.; Zheng, T.; Gibbs, S.; Chin, K.; Gray, J. W.
10.1101/2021.11.29.470281 — cancer biology — Posted on 2021-11-30
105 A subcellular cookie cutter for spatial genomics in human tissue
Bury, A.; Pyle, A.; Marcuccio, F.; Turnbull, D.; Vincent, A.; Hudson, G.; Actis, P.
10.1101/2021.11.29.470247 — genomics — Posted on 2021-11-30
107 Mapping trait versus species turnover reveals spatiotemporal variation in functional redundancy in a plant-pollinator network
Cantwell-Jones, A.; Larson, K.; Ward, A.; Bates, O. K.; Cox, T.; Brannlund, F.; Gibbons, C.; Richardson, R.; Tylianakis, J. M.; Johansson, J.; Gill, R. J.
10.1101/2021.11.29.470359 — ecology — Posted on 2021-11-30
108 Consistent predictors of microbial community composition across scales in grasslands reveal low context-dependency
Radujkovic, D.; Vicca, S.; van Rooyen, M.; Wilfahrt, P.; Brown, L.; Jentsch, A.; Reinhart, K. O.; Brown, C.; De Gruyter, J.; Jurasinski, G.; Askarizadeh, D.; Bartha, S.; Beck, R.; Blenkinsopp, T.; Cahill, J.; Campetella, G.; Canullo, R.; Chelli, S.; Enrico, L.; Fraser, L.; Hao, X.; Henry, H. A. L.; Hohn, M.; Jouri, M. H.; Koch, M.; Lawrence Lodge, R.; Li, F. Y.; Lord, J. M.; Milligan, P.; Minggagud, H.; Palmer, T.; Schröder, B.; Szabo, G.; Zhang, T.; Zimmermann, Z.; Verbruggen, E.
10.1101/2021.11.29.470306 — ecology — Posted on 2021-11-30
109 Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution
Bortolin-Cavaille, M.-l.; Quillien, A.; Thalalla Gamage, S.; Thomas, J. M.; Sas-Chen, A.; Sharma, S.; Plisson-Chastang, C.; Vandel, L.; Blader, P.; Lafontaine, D. L.; Schwartz, S.; Meier, J. L.; Cavaille, J.
10.1101/2021.11.30.470322 — molecular biology — Posted on 2021-11-30
110 Increased expression of viral sensor MDA5 in pancreatic islets and in hormone-negative endocrine cells in recent onset type 1 diabetic donors
Nigi, L.; Brusco, N.; Grieco, G. E.; Fignani, D.; Licata, G.; Formichi, C.; Aiello, E.; Marselli, L.; Marchetti, P.; Krogvold, L.; Jorgensen, K. D.; Sebastiani, G.; Dotta, F.
10.1101/2021.11.29.470364 — immunology — Posted on 2021-11-30
111 Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals
Huisman, W.; Hageman, L.; Leboux, D. A. T.; Khmelevskaya, A.; Efimov, G. A.; Roex, M. C. J.; Amsen, D.; Falkenburg, J. H. F.; Jedema, I.
10.1101/2021.11.29.470325 — immunology — Posted on 2021-11-30
116 Intravenous haloperidol and cocaine alter the distribution of T CD4+ and B lymphocytes and NKT cells in rats
Jankowski, M. M.; Ignatowska-Jankowska, B. M.; Glac, W.; Wiergowski, M.; Kazmierska-Grebowska, P.; Swiergiel, A. H.
10.1101/2021.11.28.470229 — pharmacology and toxicology — Posted on 2021-11-30
117 Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
Gosselin, M. R.; Mournetas, V.; Borczyk, M.; Bozycki, L.; Korostynski, M.; Robson, S.; Pinset, C.; Gorecki, D. C.
10.1101/2021.08.24.457331 — pathology — Posted on 2021-11-30
118 The coagulation factor IX (F9) loss of function prevents the cell cycle arrest induced by CDK4/6 inhibitors treatment
Carpintero-Fernandez, P.; Borghesan, M.; Eleftheriadou, O.; Fafian-Labora, J.; Mitchell, T.; Nightingale, T. D.; Mayan, M.; O'Loghlen, A.
10.1101/2021.11.30.470520 — cancer biology — Posted on 2021-11-30
119 Label-free imaging of macrophage phenotypes and phagocytic activity in the human dermis in vivo using two-photon excited FLIM
Kröger, M.; Scheffel, J.; Shirshin, E. A.; Schleusener, J.; Meinke, M. C.; Lademann, J.; Maurer, M.; Darvin, M.
10.1101/2021.11.29.470361 — biophysics — Posted on 2021-11-30
120 Polymorphic SNPs, short tandem repeats and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains
Mortazavi, M.; Ren, Y.; Saini, S.; Antaki, D.; St. Pierre, C.; Williams, A.; Sohni, A.; Wilkinson, M.; Gymrek, M.; Sebat, J.; Palmer, A. A.
10.1101/2020.03.16.993683 — genomics — Posted on 2021-11-30
121 Load adaptation of endocytic actin networks
Kaplan, C.; Kenny, S. J.; Chen, S.; Schoeneberg, J.; Sitarska, E.; Diz-Munoz, A.; Akamatsu, M.; Xu, K.; Drubin, D. G.
10.1101/2020.04.05.026559 — cell biology — Posted on 2021-11-30
122 Carbon-based Fluorescent Antibody Nanoprobes as Brain Tumour Glioblastoma Diagnostics.
Ghirardello, M.; Shyam, R.; Liu, X.; Garcia Millan, T.; Sittel, I.; Ramos Soriano, J.; Galan, M. C.; Kurian, K.
10.1101/2021.11.29.470408 — immunology — Posted on 2021-11-30
123 Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington's disease: Evidence from in vivo ultra-strong gradient MRI
Casella, C.; Chamberland, M.; Luque-Laguna, P.; Parker, G. D.; Rosser, A. E.; Coulthard, E.; Rickards, H.; Berry, S. C.; Jones, D. K.; Metzler-Baddeley, C.
10.1101/2021.11.29.469517 — neuroscience — Posted on 2021-11-30
125 Discoidin domain receptor regulates ensheathment, survival, and caliber of peripheral axons
Corty, M. M.; Lassetter, A. P.; Hill, J. Q.; Sheehan, A. E.; Aicher, S. A.; Freeman, M. R.
10.1101/2021.09.21.461270 — neuroscience — Posted on 2021-11-30
127 Differential EDS1 requirement for cell death activities of plant TIR-domain proteins
Lapin, D.; Johanndrees, O.; Baggs, E.; Uhlmann, C.; Locci, F.; Laessle, H. L.; Melkonian, K.; Kaeufer, K.; Dongus, J. A.; Nakagami, H.; Krasileva, K. V.; Parker, J. E.
10.1101/2021.11.29.470438 — plant biology — Posted on 2021-11-30
128 Differential regulation of flower transpiration during abiotic stress in plants
Sinha, R.; Zandalinas, S. I.; Fichman, Y.; Sen, S.; Cadenas, A. G.; Joshi, T.; Fritschi, F. B.; Mittler, R.
10.1101/2021.11.29.470467 — plant biology — Posted on 2021-11-30
130 Phytochrome B regulates reactive oxygen signaling during abiotic and biotic stress in plants
Fichman, Y.; Xiong, H.; Sengupta, S.; Azad, R. K.; Hibberd, J. M.; Liscum, E.; Mittler, R.
10.1101/2021.11.29.470478 — plant biology — Posted on 2021-11-30
131 The regeneration factors ERF114 and ERF115 act as transducers of mechanical cues to developmental pathways
Canher, B.; Lanssens, F.; Zhang, A.; Bisht, A.; Mazumdar, S.; Heyman, J.; Augstein, F.; Wolf, S.; Carlsbecker, A.; Melnyk, C. W.; De Veylder, L.
10.1101/2021.11.29.470368 — plant biology — Posted on 2021-11-30
133 A Conformational Transition of Von Willebrand Factor's D'D3 Domain Primes It For Multimerization
Gruber, S.; Loef, A.; Hausch, A.; Joehr, R.; Obser, T.; Koenig, G.; Schneppenheim, R.; Brehm, M. A.; Benoit, M.; Lipfert, J.
10.1101/2021.11.29.470312 — biophysics — Posted on 2021-11-30
138 Endocytic Trafficking Promotes Vacuolar Enlargements for Fast Cell Expansion Rates in Plants
Duenser, K.; Schoeller, M.; Loefke, C.; Xiao, N.; Parizkova, B.; Melnik, S.; Stoeger, E.; Novak, O.; Kleine-Vehn, J.
10.1101/2021.11.29.470358 — plant biology — Posted on 2021-11-30
139 Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine
Singh, K.; Faraoni, E. Y.; Dai, Y.; Chandra, V.; Vucic, E.; Mills, T.; Pruski, M.; Clark, T.; Van Buren, G.; Thosani, N. C.; Bynon, J. S.; Wray, C. J.; Bar-Sagi, D.; Poulsen, K. L.; Vornik, L. A.; Savage, M. I.; Sei, S.; Mohammed, A.; Zhao, Z.; Eltzschig, H. K.; Brown, P. H.; McAllister, F.; Bailey Lundberg, J.
10.1101/2021.11.29.470415 — cancer biology — Posted on 2021-11-30
140 Antifragile therapy
West, J.; Desai, B.; Strobl, M.; Pierik, L.; Vander Velde, R.; Armagost, C.; Miles, R.; Robertson-Tessi, M.; Marusyk, A.; Anderson, A. R. A.
10.1101/2020.10.08.331678 — cancer biology — Posted on 2021-11-30
141 Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes
Mace, T.; Gonzalez-Garcia, E.; Foulquie, D.; Carriere, F.; Pradel, J.; Durand, C.; Douls, S.; Parisot, S.; Hazard, D.
10.1101/2021.11.27.470213 — genetics — Posted on 2021-11-30
143 Distinctive nuclear zone for RAD51-mediated homologous recombinational DNA repair
Horikoshi, Y.; Shima, H.; Kobayashi, W.; Sun, J.; Schmid, V. J.; Ochiai, H.; Shi, L.; Atsuhiko, F.; Kinugasa, Y.; Kurumizaka, H.; Ikura, T.; Markaki, Y.; Tate, S.-i.; Igarashi, K.; Cremer, T.; Tashiro, S.
10.1101/2021.11.29.470307 — cell biology — Posted on 2021-11-30
144 A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in Toxoplasma gondii
Dominicus, C.; Nofal, S. D.; Broncel, M.; Kastris, N. J.; Flynn, H.; Arrizabalaga, G.; Botte, C. Y.; Invergo, B. M.; Treeck, M.
10.1101/2021.11.29.470317 — microbiology — Posted on 2021-11-30
147 General factors of white matter microstructure from DTI and NODDI in the developing brain
Vaher, K.; Galdi, P.; Blesa, M.; Sullivan, G.; Stoye, D. Q.; Quigley, A. J.; Thrippleton, M. J.; Bogaert, D.; Bastin, M. E.; Cox, S. R.; Boardman, J. P.
10.1101/2021.11.29.470344 — neuroscience — Posted on 2021-11-30
150 Structured connectivity in the cerebellum enables noise-resilient pattern separation
Nguyen, T. M.; Thomas, L. A.; Rhoades, J. L.; Ricchi, I.; Yuan, X. C.; Sheridan, A.; Hildebrand, D. G.; Funke, J.; Regehr, W. G.; Lee, W.-C. A.
10.1101/2021.11.29.470455 — neuroscience — Posted on 2021-11-30
154 Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain
Piel, L.; Rajan, K. S.; Bussotti, G.; Varet, H.; Legendre, R.; Proux, C.; Douche, T.; Giai Gianetto, Q.; Chaze, T.; Cokelaer, T.; Vojtkova, B.; Gordon-Bar, N.; Doniger, T.; Cohen-Chalamish, S.; Rengaraj, P.; Besse, C.; Boland, A.; Sadlova, J.; Deleuze, J.-F.; Matondo, M.; Unger, R.; Volf, P.; Michaeli, S.; Pescher, P.; Spaeth, G. F.
10.1101/2021.03.22.436378 — microbiology — Posted on 2021-11-30
157 Vocal markers of autism: assessing the generalizability of machine learning models
Rybner, A.; Jessen, E. T.; Mortensen, M. D.; Larsen, S. N.; Grossman, R.; Bilenberg, N.; Cantio, C.; Jepsen, J. R. M.; Weed, E.; Simonsen, A.; Fusaroli, R.
10.1101/2021.11.22.469538 — bioinformatics — Posted on 2021-11-30
165 Asymmetrical dose-response shape the evolutionary trade-off between antifungal resistance and nutrient use
Despres, P. C.; Cisneros Caballero, A. F.; Alexander, E. M.; Sonigara, R.; Gagne-Thivierge, C.; Dube, A. K.; Landry, C. R.
10.1101/2021.11.29.469899 — evolutionary biology — Posted on 2021-11-29
166 Ubiquitination drives COPI priming and Golgi SNARE localization
Date, S. S.; Xu, P.; Hepowit, N. L.; Diab, N. S.; Best, J.; Xie, B.; Du, J.; Strieter, E. R.; Jackson, L. P.; MacGurn, J. A.; Graham, T. R.
10.1101/2021.11.29.470439 — cell biology — Posted on 2021-11-29
169 Regulation of gliotoxin biosynthesis and protection in Aspergillus species
de Castro, P. A.; Moraes, M.; Colabardini, A. C.; Horta, M. A. C.; Knowles, S. L.; Raja, H. A.; Oberlies, N. H.; Koyama, Y.; Ogawa, M.; Gomi, K.; Steenwyk, J. L.; Rokas, A.; Goncales, R. A.; Duarte-Oliveira, C.; Carvalho, A.; Ries, L. N. A.; Goldman, G. H.
10.1101/2021.08.16.456458 — microbiology — Posted on 2021-11-29
170 Fast maturation of splenic dendritic cells upon TBI is associated with FLT3/FLT3L signaling
Zhang, J.; Li, Z.; Chandrasekar, A.; Shun, L.; Ludolph, A. C.; Boeckers, T. M.; Huber-Lang, M.; Roselli, F.; olde Heuvel, F.
10.1101/2021.11.29.470328 — immunology — Posted on 2021-11-29
174 Characterization of cocaine addiction-like behavior in heterogeneous stock rats
de Guglielmo, G.; Carrette, L.; Kallupi, M.; Brennan, M.; Boomhower, B.; Maturin, L.; Conlisk, D.; Sedighim, S.; Tieu, L.; Pavlich, M.; Martinez, A.; Velarde, N.; Kononoff, J.; Kimbrough, A.; Simpson, S.; Smith, L.; Shankar, K.; Crook, C.; Avelar, A.; Schweitzer, P.; Woods, L. S.; Palmer, A. A.; George, O.
10.1101/2021.07.22.453410 — neuroscience — Posted on 2021-11-29
176 On-pathway multivalency of a broadly neutralizing evolution drug candidate
Chowdhury, S.; Zielinski, D. C.; Dalldorf, C.; Rodrigues, J. V.; Palsson, B.; Shakhnovich, E.
10.1101/2021.05.17.444532 — systems biology — Posted on 2021-11-29
180 Mechanism of FtsZ assembly dynamics revealed by filament structures in different nucleotide states
Ruiz, F. M.; Huecas, S.; Santos-Aledo, A.; Prim, E. A.; Andreu, J. M.; Fernandez-Tornero, C.
10.1101/2021.11.29.470395 — biophysics — Posted on 2021-11-29
181 Brominated Lipid Probes Expose Structural Asymmetries in Constricted Membranes
Moss, F. R.; Lincoff, J.; Tucker, M.; Mohammed, A.; Grabe, M.; Frost, A.
10.1101/2021.08.24.457428 — biophysics — Posted on 2021-11-29
184 Orthoformimycin inhibits translation elongation by displacing the A-site tRNA and preventing peptide bond formation
Schedlbauer, A.; Kaminishi, T.; Fabbretti, A.; Milon, P.; Han, X.; Ochoa-Lizarralde, B.; Capuni, R.; Gualerzi, C. O.; Connell, S. R.; Fucini, P.
10.1101/2021.11.29.470217 — biochemistry — Posted on 2021-11-29
189 Systems genetics uncovers microbe-lipid-host connections in the murine gut
Zhang, Q.; Linke, V.; Overmyer, K. A.; Traeger, L. L.; Kasahara, K.; Miller, I. J.; Manson, D. E.; Polaske, T. J.; Kerby, R. L.; Kemis, J. H.; Trujillo, E. A.; Reddy, T. R.; Russell, J. D.; Schueler, K. L.; Stapleton, D. S.; Rabaglia, M. E.; Seldin, M.; Gatti, D. M.; Keele, G. R.; Pham, D. T.; Gerdt, J. P.; Vivas, E. I.; Lusis, A. J.; Keller, M. P.; Churchill, G. A.; Blackwell, H. E.; Broman, K. W.; Attie, A. D.; Coon, J. J.; Rey, F. E.
10.1101/2021.11.29.470403 — genetics — Posted on 2021-11-29
190 Archaic introgression and variation in pharmacogenes and implications for local adaptation
Wroblewski, T. H.; Witt, K. E.; Lee, S.-b.; Malhi, R. S.; Huerta-Sanchez, E.; Villanea, F.; Claw, K. G.
10.1101/2021.11.27.470071 — evolutionary biology — Posted on 2021-11-29
191 Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1
Birgy, A.; Roussel, C.; Kemble, H.; Mullaert, J.; Panigoni, K.; Chapron, A.; Chatel, J.; Magan, M.; Jacquier, H.; Cocco, S.; Monasson, R.; Tenaillon, O.
10.1101/2021.11.29.470435 — evolutionary biology — Posted on 2021-11-29
192 Epistasis is not a strong constraint on the recurrent evolution of toxin-resistant Na+,K+-ATPases among tetrapods
Mohammadi, S.; Yang, L.; Herrera-Alvarez, S.; Rodriguez-Ordonez, M. d. P.; Zhang, K.; Storz, J.; Crawford, A. J.; Andolfatto, P.
10.1101/2021.11.29.470343 — evolutionary biology — Posted on 2021-11-29
196 A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
Donker, L.; Vliem, M. J.; Canever, H.; Gomez-Gonzalez, M.; Bosch-Padros, M.; Pannekoek, W.-J.; Trepat, X.; Borghi, N.; Gloerich, M.
10.1101/2021.11.29.470352 — cell biology — Posted on 2021-11-29
197 Ectosome effect on endothelial monolayers in hyperglycemic and normoglycemic conditions
Drozdz, A.; Kołodziej, T.; Wróbel, S.; Misztal, K.; Targosz-Korecka, M.; Drab, M.; Jach, R.; Przybyło, M.; Rajfur, Z.; Stepien, E.
10.1101/2021.11.29.470234 — cell biology — Posted on 2021-11-29
198 Bet-hedging antimicrobial strategies in macrophage phagosome acidification drive the dynamics of Cryptococcus neoformans intracellular escape mechanisms
Dragotakes, Q.; Jacobs, E.; Ramirez, L. S.; Yoon, O. I.; Perez-Stable, C.; Eden, H.; Pagnotta, J.; Vij, R.; Bergman, A.; D'Alessio, F.; Casadevall, A.
10.1101/2021.11.29.470444 — microbiology — Posted on 2021-11-29
199 Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain
Piel, L.; Rajan, K. S.; Bussotti, G.; Varet, H.; Legendre, R.; Proux, C.; Douche, T.; Giai Gianetto, Q.; Chaze, T.; Cokelaer, T.; Vojtkova, B.; Gordon-Bar, N.; Doniger, T.; Cohen-Chalamish, S.; Rengaraj, P.; Besse, C.; Boland, A.; Sadlova, J.; Deleuze, J.-F.; Matondo, M.; Unger, R.; Volf, P.; Michaeli, S.; Pescher, P.; Spaeth, G. F.
10.1101/2021.03.22.436378 — microbiology — Posted on 2021-11-29
201 Regulation and mechanistic basis of macrolide resistance by the ABC-F ATPase MsrD
Fostier, C. R.; Ousalem, F.; Leroy, E. C.; Ngo, S.; Soufari, H.; Innis, C. A.; Hashem, Y.; Boel, G.
10.1101/2021.11.29.470318 — microbiology — Posted on 2021-11-29
203 Fracture healing is delayed in the absence of gasdermin signaling
Mbalaviele, G.; Sun, K.; Wang, C.; Xiao, J.; Brodt, M. D.; Yuan, L.; Yang, T.; Alippe, Y.; Hu, H.; Hao, D.; Abu-Amer, Y.; Silva, M.; Shen, J.
10.1101/2021.11.29.470391 — immunology — Posted on 2021-11-29
212 Anticipating future SARS-CoV-2 variants of concern through ab initio quantum mechanical modeling
Zaccaria, M.; Genovese, L.; Farzan, M.; Dawson, W.; Nakajima, T.; Johnson, W. E.; Momeni, B.
10.1101/2021.11.25.470044 — biophysics — Posted on 2021-11-29
216 Mapping the planet's critical natural assets for people
Chaplin-Kramer, R.; Neugarten, R.; Sharp, R. P.; Collins, P. M.; Polasky, S.; Hole, D.; Schuster, R.; Strimas-Mackey, M.; Mulligan, M.; Brandon, C.; Diaz, S.; Fluet-Chouinard, E.; Gorenflo, L.; Johnson, J. A.; Keys, P. W.; Longley-Wood, K.; McIntyre, P. B.; Noon, M.; Pascual, U.; Reidy Liermann, C.; Roehrdanz, P.; Schmidt-Traub, G.; Shaw, M. R.; Spalding, M.; Turner, W. R.; van Soesbergen, A.; Watson, R.
10.1101/2020.11.08.361014 — ecology — Posted on 2021-11-29
221 Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model
Imbrechts, M.; Maes, W.; Ampofo, L.; Van den Berghe, N.; Calcoen, B.; Van Looveren, D.; Noppen, S.; Hollevoet, K.; Vercruysse, T.; Zhang, X.; Abdelnabi, R.; Foo, C. S.-Y.; Thibaut, H. J.; Jochmans, D.; Ven, K.; Lammertyn, J.; Vanhoorelbeke, K.; Callewaert, N.; De Munter, P.; Schols, D.; Neyts, J.; Declerck, P.; Geukens, N.
10.1101/2021.11.25.470011 — immunology — Posted on 2021-11-29
222 Genomic insights into the recent population history of Mapuche Native Americans
Vicuna, L.; Mikhailova, A.; Norambuena, T.; Ilina, A.; Klimenkova, O.; Shchur, V.; Eyheramendy, S.
10.1101/2021.11.25.470066 — genetics — Posted on 2021-11-29
224 Bitter taste perception in BaYaka hunter-gatherers
Keestra, S. M.; Derkx, I.; Sikka, G.; Chaudhary, N.; Salali, G. D.
10.1101/2021.11.25.469973 — ecology — Posted on 2021-11-29
225 Reactivation of hedonic but not sensory representations in human emotional learning
Ehlers, M. R.; Kryklywy, J. H.; Beukers, A. O.; Moore, S. R.; Brandon, F. J.; Anderson, A. K.; Todd, R. M.
10.1101/2021.11.25.469891 — neuroscience — Posted on 2021-11-29
228 A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling
Klowss, J. J.; Browning, A. P.; Murphy, R. J.; Carr, E. J.; Plank, M. J.; Gunasingh, G.; Haass, N. K.; Simpson, M. J.
10.1101/2021.11.28.470300 — biophysics — Posted on 2021-11-29
234 Prenatal opioid exposure inhibits microglial sculpting of the dopamine system during adolescence
Smith, C. J.; Lintz, T.; Clark, M. J.; Malacon, K. E.; Constantino, N.; Abiad, A.; Alonso-Caraballo, Y.; Kim, V. J.; Jo, Y. C.; Bilbo, S. D.; Chartoff, E. H.
10.1101/2021.11.28.468091 — neuroscience — Posted on 2021-11-29
236 Multi-omics Analyses Provides Insight into the Biosynthesis Pathways of Fucoxanthin in Isochrysis galbana
Chen, D.; Yuan, X.; Zheng, X.; Fang, J.; Lin, G.; Li, R.; Chen, J.; He, W.; Huang, Z.; Fan, W.; Liang, L.; Lin, C.; Zhu, J.; Chen, Y.; Xue, T.
10.1101/2021.11.28.470214 — bioinformatics — Posted on 2021-11-29
238 Effects of Hypopigmentation Alleles and Ancestry on Skin Color in the Kalinago of Dominica
Ang, K. C.; Canfield, V. A.; Foster, T. C.; Reid, K. P.; Leong, S. L.; Kawasawa, Y. I.; Liu, D.; Hawley, J.; Cheng, K. C.
10.1101/2021.11.24.469305 — genetics — Posted on 2021-11-29
240 Unraveling a Bacterial Starvation Response Through the Direct Targets of a Starvation-Induced Transcriptional Activator
Ma, M.; Li, T.; Lemon, D. J.; Caro, E. A.; Ritchie, L. J.; Ryan, C.; Spearing, V. M.; Welch, R. D.; Garza, A.; Murphy, K. A.
10.1101/2021.11.28.470282 — microbiology — Posted on 2021-11-29
241 Spinal cord associative plasticity improves forelimb sensorimotor function after cervical injury
Pal, A.; Park, H.; Ramamurthy, A.; Asan, A. S.; Bethea, T.; Johnkutty, M.; Carmel, J. B.
10.1101/2020.12.07.398289 — neuroscience — Posted on 2021-11-29
248 Genetic alteration of human MYH6 is mimicked by SARS-CoV-2 polyprotein: mapping viral variants of cardiac interest
Anand, P.; Lenehan, P. J.; Niesen, M.; Yoo, U.; Patwardhan, D.; Montorzi, M.; Venkatakrishnan, A.; Soundararajan, V.
10.1101/2021.11.23.469709 — genomics — Posted on 2021-11-29
250 Structural basis of INTAC-regulated transcription
Zheng, H.; Jin, Q.; Qi, Y.; Liu, W.; Ren, Y.; Wang, X.; Chen, F. X.; Cheng, J.; Chen, X.; Xu, Y.
10.1101/2021.11.29.470345 — molecular biology — Posted on 2021-11-29
252 Preclinical efficacy, safety, and immunogenicity of PHH-1V, a second-generation COVID-19 vaccine candidate based on a novel recombinant RBD fusion heterodimer of SARS-CoV-2.
Barreiro, A.; Prenafeta, A.; Bech-Sabat, G.; Roca, M.; Perozo, E.; March, R.; Gonzalez, L.; Madrenas, L.; Corominas, J.; Fernandez, A.; Molas, M.; Pentinat, T.; Panosa, C.; Moreno, A.; Puigvert, E.; Pol, E.; Palmada, J.; Garriga, C.; Prat, T.; Vergara-Alert, J.; Lorca-Oro, C.; Roca, N.; Fernandez-Bastit, L.; Rodon, J.; Perez, M.; Segales, J.; Pradenas, E.; Marfil, S.; Trinite, B.; Ortiz, R.; Clotet, B.; Blanco, J.; Diaz Pedroza, J.; Ampudia Carrasco, R.; Rosales Salgado, Y.; Loubat Casanovas, J.; Capdevila Larripa, S.; Garcia Prado, J.; Barretina Ginesta, J.; Sistere-Oro, M.; Cebollada Rica, P
10.1101/2021.11.22.469117 — immunology — Posted on 2021-11-29
255 Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
Hung, K. L.; Luebeck, J.; Dehkordi, S. R.; Coruh, C.; Law, J. A.; Greenleaf, W. J.; Mischel, P. S.; Bafna, V.; Chang, H. Y.
10.1101/2021.11.28.470285 — cancer biology — Posted on 2021-11-29
263 Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency
Jung, Y.-E.; Lee, K. W.; Cho, J. H.; Bae, D.-W.; Jeong, B.-G.; Jung, Y.-J.; An, Y. J.; Kim, K.; Lee, G. S.; Kang, L.-W.; Moon, J. H.; Lee, J.-H.; Kim, E.-K.; Yim, H.-S.; Cha, S.-S.
10.1101/2021.11.16.468794 — biochemistry — Posted on 2021-11-29
264 Does the brain care about averages? A simple test.
Tlaie, A.; Shapcott, K. A.; Tiesinga, P.; Schölvinck, M.; Havenith, M. N.
10.1101/2021.11.28.469673 — neuroscience — Posted on 2021-11-29
265 Neurodegenerative and functional signatures of the cerebellar cortex in m.3243A>G patients
Haast, R. A.; de Coo, I. F.; Ivanov, D.; Khan, A. R.; Jansen, J. F.; Smeets, H. J.; Uludag, K.
10.1101/2021.04.30.442091 — neuroscience — Posted on 2021-11-29
266 Transcriptional kinetic synergy: a complex landscape revealed by integrating modelling and synthetic biology
Martinez Corral, R.; Park, M.; Biette, K.; Friedrich, D.; Scholes, C.; Khalil, A. S.; Gunawardena, J.; DePace, A.
10.1101/2020.08.31.276261 — systems biology — Posted on 2021-11-29
267 Microbiome-based disease prediction with multimodal variational information bottlenecks
Grazioli, F.; Siarheyeu, R.; Alqassem, I.; Henschel, A.; Pileggi, G.; Meiser, A.
10.1101/2021.06.08.447505 — bioinformatics — Posted on 2021-11-29
270 Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
Mikulasova, A.; Kent, D.; Trevisan-Herraz, M.; Karataraki, N.; Fung, K.; Ashby, C.; Cieslak, A.; Yaccoby, S.; van Rhee, F.; Zangari, M.; Thanendrarajan, S.; Schinke, C.; Morgan, G. J.; Asnafi, V.; Spicuglia, S.; Brackley, C. A.; Corcoran, A.; Hambleton, S.; Walker, B. A.; Rico, D.; Russell, L. J.
10.1101/2020.02.12.938563 — genomics — Posted on 2021-11-29
273 Archetypal Analysis for Population Genetics
Gimbernat-Mayol, J.; Mas Montserrat, D.; Bustamante, C. D.; Ioannidis, A. G.
10.1101/2021.11.28.470296 — bioinformatics — Posted on 2021-11-29
276 Diversity of an uncommon elastic hypersaline microbial mat along a small-scale transect
Espinosa-Asuar, L.; Monroy, C.; Madrigal-Trejo, D.; Navarro-Miranda, M.; Sanchez-Perez, J.; Munoz, J.; Villar, J. D.; Cifuentes, J.; Kalambokidis, M.; Esquivel-Hernandez, D. A.; Viladomat, M.; Escalante-Hernandez, A. E.; Velez, P.; Figueroa, M.; Martinez Cardenas, A.; Ramirez Barahona, S.; Gasca-Pineda, J.; Eguiarte, L. E.; Souza, V.
10.1101/2021.03.04.433984 — microbiology — Posted on 2021-11-29
281 DUAL FUNCTION OF ZIKA VIRUS NS2B-NS3 PROTEASE
Terskikh, A.; Shiryaev, S.; Cheltsov, A.; Liddington, R. C.
10.1101/2021.11.28.470275 — immunology — Posted on 2021-11-28
283 The gradient model of brain organization in decisions involving 'empathy for pain'
Labek, K.; Sittenberger, E.; Kienhoefer, V.; Rabl, L.; Messina, I.; Schurz, M.; Stingl, J. C.; Viviani, R.
10.1101/2021.11.28.470235 — neuroscience — Posted on 2021-11-28
284 Functionalizing lipid sponge droplets with DNA
Cho, C.; Niederholtmeyer, H.; Seo, H.; Bhattacharya, A.; Devaraj, N. K.
10.1101/2021.11.28.470255 — synthetic biology — Posted on 2021-11-28
291 Global analysis of human-to-mouse intercellular RNA transfer in cell culture
Dasgupta, S.; Dyagi, D. Y.; Haimovich, G.; Wyler, E.; Olender, T.; Singer, R. H.; Landthaler, M.; Gerst, J. E.
10.1101/2021.11.28.470233 — cell biology — Posted on 2021-11-28
292 The phenotypic landscape of essential human genes
Funk, L.; Su, K.-C.; Feldman, D.; Singh, A.; Moodie, B.; Blainey, P.; Cheeseman, I. M.
10.1101/2021.11.28.470116 — cell biology — Posted on 2021-11-28
293 Joint Learning of Full-structure Noise in Hierarchical Bayesian Regression Models
Hashemi, A.; Cai, C.; Gao, Y.; Ghosh, S.; Müller, K.-R.; Nagarajan, S.; Haufe, S.
10.1101/2021.11.28.470264 — neuroscience — Posted on 2021-11-28
294 Does the brain care about averages? A simple test.
Tlaie, A.; Shapcott, K. A.; Tiesinga, P.; Schölvinck, M.; Havenith, M. N.
10.1101/2021.11.28.469673 — neuroscience — Posted on 2021-11-28
296 A conserved long intergenic non-coding RNA containing snoRNA sequences, lncCOBRA1, affects Arabidopsis germination and development
Kramer, M. C.; Kim, H. J.; Palos, K. R.; Garcia, B. A.; Lyons, E.; Beilstein, M. A.; Nelson, A. D. L.; Gregory, B. D.
10.1101/2021.11.28.470209 — plant biology — Posted on 2021-11-28
299 Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma
Yang, Y.; Oellerich, T.; Chen, P.; Bolomsky, A.; Ceribelli, M.; Haupl, B.; Wright, G. W.; Phelan, J. D.; Huang, D. W.; Lord, J. W.; Van Winkle, C. K.; Yu, X.; Wisnieski, J.; Wang, J. Q.; Tosto, F. A.; Beck, E.; Wilson, K.; McKnight, C.; Travers, J.; Klumpp-Thomas, C.; Smith, G. A.; Pittaluga, S.; Maric, I.; Kazandjian, D.; Thomas, C. J.; Young, R. M.
10.1101/2021.11.28.470260 — cancer biology — Posted on 2021-11-28
300 Analysis of 8000 proteins and reduced carry over significantly increase the throughput of single-shot proteomics
Stejskal, K.; Op de Beeck, J.; Matzinger, M.; Duernberger, G.; Boychenko, O.; Jacobs, P.; Mechtler, K.
10.1101/2021.11.28.470272 — biochemistry — Posted on 2021-11-28
302 Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of airway allergic inflammation
Sagar, S.; Faizan, M. I.; Chaudhary, N.; Gheware, A.; Sharma, K.; Azmi, I.; Singh, V. P.; Kharya, G.; Mabalirajan, U.; Agrawal, A.; Ahmad, T.; Roy, S. S.
10.1101/2021.11.27.470183 — cell biology — Posted on 2021-11-28
303 Effect of host-switching on the eco-evolutionary patterns of parasites
D'Bastiani, E.; Princepe, D.; Campiao, K. M.; Darcie Marquitti, F. M.; Boeger, W. A.; Araujo, S. B. L.
10.1101/2021.11.27.470149 — ecology — Posted on 2021-11-28
304 An essential role for a discrete parasubthalamic nucleus subpopulation in appetite suppression
Kim, J. H.; Kromm, G. H.; Barnhill, O. K.; Han, K.; Heuer, L. B.; Loomis, S.; Newman, M. C.; Sperber, J.; Legan, T. B.; Gulamali, F. F.; Jensen, K. E.; Funderburk, S. C.; Krashes, M. J.; Carter, M. E.
10.1101/2021.11.10.468058 — neuroscience — Posted on 2021-11-28
308 High-throughput phenotyping reveals a link between transpiration efficiency and transpiration restriction under high evaporative demand and new loci controlling water use-related traits in African rice, Oryza glaberrima Steud.
Affortit, P.; Effa Effa, B.; Ndoye, M. S.; Moukouanga, D.; Luchaire, N.; Cabrera-Bosquet, L.; Peralvarez, M. C.; Pilloni, R.; Welcker, C.; Champion, A.; Gantet, P.; Diedhiou, A. G.; Manneh, B.; Aroca, R.; Vadez, V.; Laplaze, L.; Cubry, P.; Grondin, A.
10.1101/2021.11.28.470237 — physiology — Posted on 2021-11-28
309 Intravenous haloperidol and cocaine alter the distribution of T CD4+ and B lymphocytes and NKT cells in rats
Jankowski, M. M.; Ignatowska-Jankowska, B. M.; Glac, W.; Wiergowski, M.; Kazmierska-Grebowska, P.; Swiergiel, A. H.
10.1101/2021.11.28.470229 — pharmacology and toxicology — Posted on 2021-11-28
311 Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis
Popova, J. V.; Pavlova, G. A.; Razuvaeva, A. V.; Yarinich, L. A.; Andreyeva, E. N.; Anders, A. F.; Galimova, Y.; Renda, F.; Somma, M. P.; Pindyurin, A. V.; Gatti, M.
10.1101/2021.11.19.469214 — genetics — Posted on 2021-11-28
313 Convergent evolution of mevalonate pathway in Inonotus obliquus and Betula pendula.
Safronov, O.; Lutfullahoglubal, G.; Sipari, N.; Wilkens, M.; Safdari, P.; Smolander, O.-P.; Lihavainen, J.; Silvan, N.; Rajaraman, S.; Laine, P. K.; Paulin, L.; Auvinen, P.; Sarjala, T.; Overmyer, K.; Kangasjarvi, J.; Battersby, B.; Richter, U.; Salojarvi, J.
10.1101/2021.11.28.470225 — evolutionary biology — Posted on 2021-11-28
314 On the nature of the earliest known life forms
Kanaparthi, D.; Lampe, M.; Zhu, B.; Boesen, T.; Klingl, A.; Schwille, P.; Lueders, T.
10.1101/2021.08.16.456462 — evolutionary biology — Posted on 2021-11-28
319 propeller: testing for differences in cell type proportions in single cell data
Phipson, B.; Sim, C. B.; Porrello, E. R.; Hewitt, A. W.; Powell, J.; Oshlack, A.
10.1101/2021.11.28.470236 — bioinformatics — Posted on 2021-11-28
326 Improved reference genome annotation of Brassica rapa by PacBio RNA sequencing
Zhang, Z.; Guo, J.; Cai, X.; Li, Y.; Xi, X.; Lin, R.; Liang, J.; Wang, X.; Wu, J.
10.1101/2021.11.27.470189 — plant biology — Posted on 2021-11-28
329 Enemy or ally: a genomic approach to elucidate the lifestyle of Phyllosticta citrichinaensis
Buijs, V. A.; Groenewald, J. Z.; Haridas, S.; LaButti, K.; Lipzen, A.; Martin, F. M.; Barry, K.; Grigoriev, I. V.; Crous, P. W.; Seidl, M. F.
10.1101/2021.11.27.470207 — bioinformatics — Posted on 2021-11-28
332 Biofabrication of development-inspired scaffolds for regeneration of the annulus fibrosus macro- and microarchitecture
Kluser, N.; Sprecher, C.; Alig, G. U.; Haeckel, S.; Albers, C. E.; Alini, M.; Grad, S.; Eglin, D.; Vernengo, A. J.
10.1101/2021.11.03.467069 — bioengineering — Posted on 2021-11-28
333 Metabolic crossfeeding structures the assembly of polysaccharide degrading communities
Pontrelli, S.; Szabo, R.; Pollak, S.; Schwartzman, J. A.; Ledezma-Tejeida, D.; Cordero, O. X.; Sauer, U.
10.1101/2021.06.22.449372 — microbiology — Posted on 2021-11-28
334 Archaic introgression and variation in pharmacogenes and implications for local adaptation
Wroblewski, T. H.; Witt, K. E.; Lee, S.-b.; Malhi, R. S.; Huerta-Sanchez, E.; Villanea, F.; Claw, K. G.
10.1101/2021.11.27.470071 — evolutionary biology — Posted on 2021-11-28
335 Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety
Watari, H.; Kageyama, H.; Masubuchi, N.; Nakajima, H.; Onodera, K.; Focia, P. J.; Oshiro, T.; Matsui, T.; Kodera, Y.; Ogawa, T.; Yokoyama, T.; Hirayama, M.; Hori, K.; Freymann, D. M.; Komatsu, N.; Araki, M.; Tanaka, Y.; Sakai, R.
10.1101/2021.10.29.466502 — cell biology — Posted on 2021-11-28
336 Single-cell in vivo brain optogenetic stimulation by two-photon excitation fluorescence transfer
Tong, L.; Yuan, P.; Xue, Y.; Chen, M.; Chen, F.; Bewersdorf, J.; Zhou, J. Z.; Grutzendler, J.
10.1101/2020.06.29.179077 — neuroscience — Posted on 2021-11-28
337 Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and aging
Freitag, K.; Eede, P.; Ivanov, A.; Schneeberger, S.; Borodina, T.; Sauer, S.; Beule, D.; Heppner, F. L.
10.1101/2021.08.02.454573 — neuroscience — Posted on 2021-11-28
338 Designing and interpreting 4D tumour spheroid experiments
Murphy, R. J.; Browning, A. P.; Gunasingh, G.; Haass, N. K.; Simpson, M. J.
10.1101/2021.08.18.456910 — biophysics — Posted on 2021-11-27
339 TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo
Chen, L.; Roake, C. M.; Maccallini, P.; Bavasso, F.; Dehghannasiri, R.; Santonicola, P.; Mendoza-Ferreira, N.; Scatolini, L.; Rizzuti, L.; Esposito, A.; Gallotta, I.; Francia, S.; Cacchione, S.; Galati, A.; Palumbo, V.; Tartaglia, G. G.; Colantoni, A.; Proietti, G.; Wu, Y.; Hammerschmidt, M.; De Pitta, C.; Sales, G.; Salzman, J.; Pellizzoni, L.; Wirth, B.; Di Schiavi, E.; Gatti, M.; Artandi, S. E.; Raffa, G. D.
10.1101/2020.10.27.356782 — genetics — Posted on 2021-11-27
340 Two Liberibacter Effectors Combine to Suppress Critical Innate Immune Defenses and Facilitate Huanglongbing Pathogenesis in Citrus
Basu, S.; Huynh, L.; Zhang, S.; Rabara, R.; velasquez, j.; Nguyen, H.; Hao, G.; Miles, G.; Shi, Q.; Stover, E.; Gupta, G.
10.1101/2021.11.26.470170 — plant biology — Posted on 2021-11-27
342 Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of airway allergic inflammation
Sagar, S.; Faizan, M. I.; Chaudhary, N.; Gheware, A.; Sharma, K.; Azmi, I.; Singh, V. P.; Gaurav Kharya, G. K.; Mabalirajan, U.; Agrawal, A.; Ahmad, T.; Roy, S. S.; Ahmad, T.; Roy, S. S.
10.1101/2021.11.27.470183 — cell biology — Posted on 2021-11-27
343 Time course of EEG power during creative problem-solving with insight or remote thinking
Bieth, T.; Ovando-Tellez, M.; Lopez-Persem, A.; Garcin, B.; Hugueville, L.; Lehongre, K.; Levy, R.; George, N.; Volle, E.
10.1101/2021.11.26.470102 — neuroscience — Posted on 2021-11-27
344 Mural cell SRF controls pericyte migration, vessel patterning and blood flow
Orlich, M. M.; Dieguez-Hurtado, R.; Muehlfriedel, R.; Sothilingam, V.; Wolburg, H.; Oender, C. E.; Woelffing, P.; Betsholtz, C.; Gaengel, K.; Seeliger, M.; Adams, R. H.; Nordheim, A.
10.1101/2021.11.26.470022 — developmental biology — Posted on 2021-11-27
349 A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosis
Li, S.; Poulton, N. C.; Chang, J. S.; Azadian, Z. A.; Dejusus, M. A.; Ruecker, N.; Zimmerman, M. D.; Eckartt, K.; Bosch, B.; Engelhart, C. A.; Sullivan, D.; Gengenbacher, M.; Dartois, V. A.; Schnappinger, D.; Rock, J. M.
10.1101/2021.11.27.469863 — microbiology — Posted on 2021-11-27
353 Synaptic Activity-Dependent Changes in the Hippocampal Palmitoylome
Nasseri, G.; Matin, N.; Tosefsky, K.; Stacey, R. G.; Flibotte, S.; Hollman, R.; Wild, A. R.; Foster, L. J.; Bamji, S. X.
10.1101/2021.11.26.470153 — neuroscience — Posted on 2021-11-27
354 GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice
Lass, G.; Li, X.; de Burgh, R. A.; Ivanova, D.; McIntyre, C.; Lin, X.-H.; Colledge, W. H.; Lightman, S.; O'Byrne, K.
10.1101/2021.11.27.470131 — neuroscience — Posted on 2021-11-27
356 Type II muscle fibre properties are not associated with balance recovery following large perturbations during walking in young and older adults
McCrum, C.; Grevendonk, L.; Schaart, G.; Moonen-Kornips, E.; Jörgensen, J. A.; Gemmink, A.; Meijer, K.; Hoeks, J.
10.1101/2021.11.26.470167 — physiology — Posted on 2021-11-27
358 DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
Michaels, Y. S.; Edgar, J. M.; Major, M. C.; Castle, E. L.; Zimmerman, C.; Yin, T.; Hagner, A.; Lau, C.; Ibanez-Rios, M. I.; Knapp, D. J. H. F.; Zandstra, P. W.
10.1101/2021.11.26.470145 — bioengineering — Posted on 2021-11-27
363 Genome assembly of Danaus chrysippus and comparison with the Monarch Danaus plexippus
Singh, K. S.; De-Kayne, R.; Omufwoko, K. S.; Martins, D. J.; Bass, C.; ffrench-Constant, R.; Martin, S. H.
10.1101/2021.11.27.470194 — genomics — Posted on 2021-11-27
368 Life Strategies in Placozoa
Romanova, D.; Nikitin, M. A.; Shchenkov, S. V.; Moroz, L. L.
10.1101/2021.11.26.470175 — developmental biology — Posted on 2021-11-27
369 A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche
Madissoon, E.; Oliver, A. J.; Kleshchevnikov, V.; Wilbrey-Clark, A.; Polanski, K.; Ribeiro Orsi, A. E.; Mamanova, L.; Bolt, L.; Pett, J. P.; Huang, N.; Elmentaite, R.; Richoz, N.; He, P.; Dabrowska, M.; Tuck, E.; Prigmore, E.; Knights, A.; Oszlanczi, A.; Hunter, A.; Pritchard, S.; Vieira, S. F.; Patel, M.; Mahbubani, K.; Georgakopoulos, N.; Clatworthy, M.; Stegle, O.; Bayraktar, O. A.; Saeb-Parsy, K.; Kumasaka, N.; Teichmann, S. A.; Meyer, K. B.
10.1101/2021.11.26.470108 — cell biology — Posted on 2021-11-27
371 Isolation of a Bacillus safensis from mine tailings in Peru, genomic characterization and characterization of its cyanide- degrading enzyme CynD
Justo Arevalo, S.; Zapata Sifuentes, D.; Cuba Portocarrero, A.; Brescia Reategui, M.; Monge Pimentel, C.; Farage Martins, L.; Marques Pierry, P.; Morais Piroupo, C.; Guerra Santa Cruz, A.; Quinones Aguilar, M.; Farah, C. S.; Setubal, J. C.; da Silva, A. M.
10.1101/2021.11.27.470173 — microbiology — Posted on 2021-11-27
373 Salmonella enterica serovar Typhimurium from Wild Birds in the United States Represent Distinct Lineages Defined by Bird Type
Fu, Y.; M'ikanatha, N. M.; Lorch, J. M.; Blehert, D. S.; Berlowski-Zier, B.; Whitehouse, C. A.; Li, S.; Deng, X.; Smith, J. C.; Shariat, N. W.; Nawrocki, E. M.; Dudley, E. G.
10.1101/2021.11.26.470158 — microbiology — Posted on 2021-11-27
375 Identification of bacteria by poly-aromatic hydrocarbons biosensors
Shlosberg, Y.; Farber, Y.; Hasson, S.; Bulatov, V.; Schechter, I.
10.1101/2021.11.27.470193 — microbiology — Posted on 2021-11-27
376 Deeper than you think: partisan-dependent brain response
Katabi, N.; Simon, H.; Yakim, S.; Ravreby, I.; Yeshurun, Y.
10.1101/2021.11.23.469735 — neuroscience — Posted on 2021-11-27
377 RNA Profiling of Neuropathic Pain-Associated Human DRGs Reveal Sex-differences in Neuro-immune Interactions Promoting Pain
Ray, P.; Shiers, S.; Tavares Ferreira, D.; Sankaranarayanan, I.; Uhelski, M. L.; Li, Y.; North, R. Y.; Tatsui, C. E.; Dussor, G.; Burton, M. D.; Dougherty, P. M.; Price, T. J.
10.1101/2021.11.27.470190 — neuroscience — Posted on 2021-11-27
381 Divergence and convergence of cortical encoding during word reading in bilinguals
Geng, S.; Guo, W.; Xu, K.; Jia, T.; Zhou, W.; Blakemore, C.; Tan, L.-H.; Cao, M.; Feng, J.
10.1101/2021.11.25.470068 — neuroscience — Posted on 2021-11-27
386 ENNGene: an Easy Neural Network model building tool for Genomics
Chalupova, E.; Vaculik, O.; Jozefov, F.; Polacek, J.; Majtner, T.; Alexiou, P.
10.1101/2021.11.26.424041 — bioinformatics — Posted on 2021-11-27
387 NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects
Dubos, T.; Poulet, A.; Thomson, G.; Pery, E.; Chausse, F.; Tatout, C.; Desset, S.; van Wolfswinkel, J. C.; Jacob, Y.
10.1101/2021.11.26.470128 — bioinformatics — Posted on 2021-11-27
388 Deep learning applications in single-cell omics data analysis
Erfanian, N.; Heydari, A. A.; Ianez, P.; Derakhshani, A.; Ghasemigol, M.; Farahpour, M.; Nasseri, S.; Safarpour, H.; Sahebkar, A.
10.1101/2021.11.26.470166 — bioinformatics — Posted on 2021-11-27
389 MECP2pedia: A Comprehensive Transcriptome Portal for MECP2 Disease Research
Wan, Y.-W.; Trostle, A. J.; Li, L.; Kim, S.-Y.; Wan, J.; Al-Ouran, R.; Yalamanchili, H. K.; Liu, Z.
10.1101/2021.11.27.470197 — bioinformatics — Posted on 2021-11-27
390 In Vitro Proliferation and Long-Term Preservation of Functional Primary Rat Hepatocytes in Cell Fibers
Mazari-Arrighi, E.; Okitsu, T.; Teramae, H.; Aoyagi, H.; Kiyosawa, M.; Yano, M.; Takeuchi, S.
10.1101/2021.11.27.467621 — bioengineering — Posted on 2021-11-27
392 Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer
Polanco, E. R.; Moustafa, T. E.; Butterfield, A.; Scherer, S. D.; Cortes-Sanchez, E.; Bodily, T.; Spike, B. T.; Welm, B. E.; Bernard, P. S.; Zangle, T. A.
10.1101/2021.11.26.467625 — bioengineering — Posted on 2021-11-27
399 Evidence for alternate stable states in an Ecuadorian Andean Cloud Forest
Mariscal Chavez, A.; Thomas, D. C.; Haffenden, A.; Manobanda, R.; Angel Chinchero, M.; Simba Larco, J. D.; Jaramillo, E.; Roy, B. A.; Peck, M.
10.1101/2021.11.26.470126 — ecology — Posted on 2021-11-27
400 On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation
Jeziorska, D. M.; Tunnacliffe, E. A. J.; Brown, J. M.; Ayyub, H.; Sloane-Stanley, J. A.; Sharpe, J. A.; Lagerholm, B. C.; Babbs, C.; Smith, A. J. H.; Buckle, V. J.; Higgs, D.
10.1101/2021.11.26.470114 — molecular biology — Posted on 2021-11-27
403 Simultaneous pathway engagement of translation in astrocytes, circadian rhythm in GABAergic neurons and cytoskeleton in glutamatergic neurons precede electroencephalographic changes in neurodegenerative prion disease
Kaczmarczyk, L. T.; Schleif, M.; Dittrich, L.; Williams, R.; Koderman, M.; Bansal, V.; Rajput, A.; Schulte, T.; Jonson, M.; Krost, C.; Testaquadra, F.; Bonn, S.; Jackson, W. S.
10.1101/2021.11.26.470101 — neuroscience — Posted on 2021-11-27
407 A brainstem integrator for self-localization and positional homeostasis
Yang, E.; Zwart, M. F.; Rubinov, M.; James, B.; Wei, Z.; Narayan, S.; Vladimirov, N.; Mensh, B. D.; Fitzgerald, J. E.; Ahrens, M. B.
10.1101/2021.11.26.468907 — neuroscience — Posted on 2021-11-27
408 Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of Dyserythropoiesis
Berastegui, N.; Ainciburu, M.; Romero, J. P.; Alfonso-Pierola, A.; Philippe, C.; Vilas-Zornoza, A.; San Martin, P.; Ordonez, R.; Alignani, D. O.; Sarvide, S.; Castro, L.; Lamo-Espinosa, J. M.; San-Julian, M.; Jimenez, T.; Lopez Cardenas, F.; Muntion, S.; Sanchez-Guijo, F.; Molero, A.; Montoro, J.; Tazon, B.; Serrano, G.; Diaz-Mazkiaran, A.; Hernaez, M.; Huerga, S.; Copley, F.; Rio-Machin, A.; Maurano, M. T.; Diez-Campelo, M.; Valcarcel, D.; Rouault-Pierre, K.; Lara-Astiaso, D.; Ezponda, T.; Prosper, F.
10.1101/2021.09.08.459384 — cancer biology — Posted on 2021-11-27
411 Molecular diversity maintained by long-term balancing selection in mating loci defines multiple mating types in fungi
Peris, D.; Lu, D. S.; Kinneberg, V. B.; Methlie, I.-S. H.; Dahl, M. S.; James, T. Y.; Kauserud, H.; Skrede, I.
10.1101/2021.09.10.459787 — genomics — Posted on 2021-11-27
412 Neural crest-related NXPH1/α-NRXN signaling opposes neuroblastoma malignancy by inhibiting metastasis
Fanlo-Escudero, L.; Gomez-Gonzalez, S.; Sangrador, I.; Gautier, E. L.; Usieto, S.; Rebollo, E.; Vila-Ubach, M.; Carcaboso, A. M.; Celia-Terrassa, T.; Lavarino, C.; Marti, E.; Le Dreau, G.
10.1101/2021.11.26.470092 — neuroscience — Posted on 2021-11-27
417 A flexible electronic strain sensor for the real-time monitoring of tumor regression
Abramson, A.; Chan, C.; Khan, Y.; Mermin-Bunnell, A.; Matsuhisa, N.; Fong, R.; Shad, R.; Hiesinger, W.; Mallick, P.; Gambhir, S. S.; Bao, Z.
10.1101/2021.09.16.460551 — bioengineering — Posted on 2021-11-27
418 PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
Gourdon, P.; Li, P.; Nayeri, N.; Gorecki, K.; Ramos Becares, E.; Wang, K.; Mahato, D. R.; Andersson, M.; Abeyrathna, S.; Lindkvist-Petersson, K.; Meloni, G.; Missel, J. W.
10.1101/2021.11.26.470079 — biochemistry — Posted on 2021-11-27
422 Proteomic Characterization of Serum Small Extracellular Vesicles in Human Breast Cancer
Xu, G.; Huang, W.; Du, S.; Huang, M.; Lyu, J.; Zhou, F.; Zhu, R.; Cao, Y.; Xv, J.; Li, N.; Yu, G.; Jiang, B.; Gires, O.; Zhou, L.; Zhang, H.; Ding, C.; Wang, H.
10.1101/2021.11.26.470104 — bioinformatics — Posted on 2021-11-27
423 Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety
Watari, H.; Kageyama, H.; Masubuchi, N.; Nakajima, H.; Onodera, K.; Focia, P. J.; Oshiro, T.; Matsui, T.; Kodera, Y.; Ogawa, T.; Yokoyama, T.; Hirayama, M.; Hori, K.; Freymann, D. M.; Komatsu, N.; Araki, M.; Tanaka, Y.; Sakai, R.
10.1101/2021.10.29.466502 — cell biology — Posted on 2021-11-27
425 Mechanosensitive Ion Channel Piezo1 Regulates Myocyte Fusion during Skeletal Myogenesis
Ortuste Quiroga, H. P.; Ganassi, M.; Yokoyama, S.; Nakamura, K.; Yamashita, T.; Raimbach, D.; Hagiwara, A.; Harrington, O.; Breach-Teji, J.; Asakura, A.; Suzuki, Y.; Tominaga, M.; Zammit, P. S.; Goto, K.
10.1101/2020.09.27.315242 — molecular biology — Posted on 2021-11-27
429 Host Induced Gene Silencing of the Sclerotinia sclerotiorum ABHYDROLASE-3 gene reduces disease severity in Brassica napus
Wytinck, N.; Ziegler, D. J.; Walker, P. L.; Sullivan, D. S.; Biggar, K. T.; Khan, D.; Sakariyahu, S. K.; Wilkins, O.; Whyard, S.; Belmonte, M. F.
10.1101/2021.11.26.470135 — plant biology — Posted on 2021-11-26
433 Inference and validation of an integrated regulatory network of autism
Ganji, M.; Emadi-Baygi, M.; Mohammadtaheri, F.; Mirmohammadsadeghi, N.; Malek, M.; Nikpour, P.
10.1101/2020.06.08.139733 — systems biology — Posted on 2021-11-26
437 Cytostatic hypothermia and its impact on glioblastoma and survival
Enam, S. F.; Kilic, C. Y.; Huang, J.; Kang, B. J.; Chen, R.; Tribble, C. S.; Ilich, E.; Betancur, M. I.; Blocker, S. J.; Owen, S.; Buckley, A. F.; Lyon, J. G.; Bellamkonda, R. V.
10.1101/2021.03.25.436870 — bioengineering — Posted on 2021-11-26
438 Cryo-EM structure of the Smc5/6 holo-complex
Hallett, S. T.; Campbell Harry, I.; Schellenberger, P.; Zhou, L.; Cronin, N. B.; Baxter, J.; Etheridge, T. J.; Murray, J. M.; Oliver, A. W.
10.1101/2021.11.25.470006 — biochemistry — Posted on 2021-11-26
440 Combining metabolomics and experimental evolution reveals key mechanisms underlying longevity differences in laboratory evolved Drosophila melanogaster populations
Phillips, M.; Arnold, K. R.; Vue, Z.; Beasley, H.; Garza Lopez, E.; Marshall, A.; Morton, D.; McReynolds, M. R.; Barter, T. T.; Hinton, A.
10.1101/2021.10.16.464668 — evolutionary biology — Posted on 2021-11-26
442 Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio
Evans, B.; Garner, T.; DeLeonibus, C.; Wearing, O.; Shiels, H.; Hurlstone, A. H.; Clayton, P.; Stevens, A.
10.1101/2020.12.06.413633 — developmental biology — Posted on 2021-11-26
443 Mouse CHD4-NURD is required for neonatal spermatogonia survival and normal gonad development
de Castro, R. O.; Previato, L.; Carbajal, A.; Goitea, V.; Griffin, C.; Pezza, R.
10.1101/687137 — developmental biology — Posted on 2021-11-26
447 Experimental Investigation Of Pulse Sterilization Of Pathogens
Chumakov, V. I.; Ostryzhnyi, M.; Kharchenko, O.; Rybalchenko, N.; Muraveinyk, V.; Tarasevich, A.
10.1101/2021.11.25.470057 — microbiology — Posted on 2021-11-26
448 Input to layer 1 of somatosensory cortex: Local input outweighs long-range and can modulate the activity of layer 1 interneurons
Ledderose, J.; Zolnik, T. A.; Toumazou, M.; Trimbuch, T.; Rosenmund, C.; Eickholt, B. J.; Jaeger, D.; Larkum, M. E.; Sachdev, R.
10.1101/2021.11.26.469979 — neuroscience — Posted on 2021-11-26
450 Neurexins Regulate GABA Co-release by Dopamine Neurons
Ducrot, C.; de Carvalho, G.; Delignat-Lavaud, B.; Delmas, C.; Giguere, N.; Mukherjee, S.; Burke, S.; Bourque, M.-J.; Parent, M.; Chen, L. Y.; Trudeau, L.-E.
10.1101/2021.10.17.464666 — neuroscience — Posted on 2021-11-26
451 A standardized non-visual behavioral event is broadcasted homogeneously across cortical visual areas without modulating visual responses
Ramadan, M.; Lee, E. K.; de Vries, S.; Caldejon, S.; Kato, I.; Roll, K.; Griffin, F.; Nguyen, T.; Larkin, J.; Rhoads, P.; Mace, K.; Kriedberg, A.; Howard, R.; Berbesque, N.; Lecoq, J.
10.1101/2020.12.15.422967 — neuroscience — Posted on 2021-11-26
454 Spatial resolution of an integrated C4+CAM photosynthetic metabolism
Moreno-Villena, J. J.; Zhou, H.; Gilman, I. S.; Tausta, S. L.; Cheung, C. Y. M.
10.1101/2021.11.25.470062 — plant biology — Posted on 2021-11-26
456 Bagaza virus in wild birds, Portugal, 2021
Queiros, J.; Barros, S.; Sanchez-Cano, A.; Henriques, M.; Fagulha, T.; dos Santos, F. A.; Duarte, M.; Goncalves, C.; Goncalves, D.; Rodrigues, M.; Cabrera, T. C.; Fernandez de Mera, I. G.; Gortazar, C.; Hofle, U.; Alves, P. C.
10.1101/2021.11.26.470055 — pathology — Posted on 2021-11-26
457 Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1
Coppo, R.; Kondo, J.; Iida, K.; Okada, M.; Onuma, K.; Tanaka, Y.; Kamada, M.; Ohue, M.; Kawada, K.; Obama, K.; Inoue, M.
10.1101/2021.11.25.469977 — cancer biology — Posted on 2021-11-26
461 Meisosomes, folded membrane platforms, link the epidermis to the cuticle in C. elegans
Aggad, D.; Omi, S.; Essmann, C. L.; Brouilly, N.; Richard, F.; Cazevieille, C.; Politi, K. A.; Hall, D. D.; Ewbank, J.; Pujol, R.; Pujol, N.
10.1101/2021.11.26.470028 — cell biology — Posted on 2021-11-26
462 Adaptor linked K63 di-Ubiquitin activates Nedd4/Rsp5 E3 ligase
Zhu, L.; Zhang, Q.; Cordeiro, C.; Banjade, S.; Sardana, R.; Mao, Y.; Emr, S. D.
10.1101/2021.11.25.470069 — cell biology — Posted on 2021-11-26
463 High resolution species detection: accurate long read eDNA metabarcoding of North Sea fish using Oxford Nanopore sequencing
Doorenspleet, K.; Jansen, L.; Oosterbroek, S.; Bos, O.; Kamermans, P.; Janse, M.; Wurz, E.; Murk, A.; Nijland, R.
10.1101/2021.11.26.470087 — molecular biology — Posted on 2021-11-26
464 On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation
Jeziorska, D. M.; Tunnaclife, E. A. J.; Brown, J. M.; Ayyub, H.; Sloane-Stanley, J. A.; Sharpe, J. A.; Lagerholm, B. C.; Babbs, C.; Smith, A. J. H.; Buckle, V. J.; Higgs, D.
10.1101/2021.11.26.470114 — molecular biology — Posted on 2021-11-26
468 Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation
Brandhofer, M.; Hoffmann, A.; Blanchet, X.; Siminkovitch, E.; Rohlfing, A.-K.; El Bounkari, O.; Nestele, J. A.; Bild, A.; Kontos, C.; Hille, K.; Rohde, V.; Froehlich, A.; Golemi, J.; Goekce, O.; Scheiermann, P.; Tsilimparis, N.; Kempf, W. E.; Maegdefessel, L.; Megens, R. T. A.; Ippel, H.; Koenen, R. R.; Mayo, K.; Gawaz, M.; Kapurniotu, A.; Weber, C.; von Hundelshausen, P.; Bernhagen, J.
10.1101/2021.11.26.470090 — immunology — Posted on 2021-11-26
469 Patients with recurrent PVL+-Staphylococcus aureus infections show enhanced sensitivity to PVL-mediated formation of atypical NETs
Jhelum, H.; Cerina, D.; Harbort, C. J.; Lindner, A.; Hanitsch, L. G.; Leistner, R.; Schröder, J.-T.; von Bernuth, H.; Stegemann, M. S.; Schürmann, M.; Zychlinsky, A.; Krüger, R.; Marsman, G.
10.1101/2021.11.26.470012 — immunology — Posted on 2021-11-26
470 Reversible brain edema in experimental cerebral malaria is associated with transcellular blood-brain barrier disruption and delayed microhemorrhages
Hoffmann, A.; Jin, J.; Aida, M.; Wai, C. H.; Mohanty, S.; Sahu, P. K.; Pattnaik, R.; Pirpamer, L.; Fischer, M.; Heiland, S.; Lanzer, M.; Frischknecht, F.; Mueller, A.-K.; Pfeil, J.; Majhi, M.; Cyrklaff, M.; Wassmer, S. C.; Bendszus, M.
10.1101/2021.11.26.470078 — neuroscience — Posted on 2021-11-26
471 Viral dynamics and immune responses to foot-and-mouth disease virus in African buffalo (Syncerus caffer).
Perez-Martin, E.; Beechler, B.; Scott, K.; de Klerk-Lorist, L.-M.; Zhang, F.; Limon, G.; Dugovich, B.; Gubbins, S.; Botha, A.; Juleff, N.; Hetem, R.; van Schalkwyk, L.; Maree, F.; Jolles, A.; Charleston, B.
10.1101/2021.11.24.469808 — zoology — Posted on 2021-11-26
473 Homologous recombination repair creates mutations in the non-coding genome that alter Topoisomerase-1 cleavage sites & orchestrates irinotecan resistance
Kumar, S.; Gahramanov, V.; Yaglom, J.; Patel, S.; Kaczmarczyk, L.; Alexandrov, I.; Gerlitz, G.; Salmon-Divon, M.; Sherman, M. Y.
10.1101/2021.11.26.470089 — cancer biology — Posted on 2021-11-26
474 Mars, a molecule archive suite for reproducible analysis and reporting of single molecule properties from bioimages
Huisjes, N. M.; Retzer, T. M.; Scherr, M. J.; Agarwal, R.; Safaric, B.; Minnen, A.; Duderstadt, K. E.
10.1101/2021.11.26.470105 — biophysics — Posted on 2021-11-26
475 Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers
Saha, S.; Khan, N.; Comi, T.; Verhagen, A.; Sasmal, A.; Diaz, S.; Yu, H.; Chen, X.; Akey, J. M.; Frank, M.; Gagneux, P.; Varki, A.
10.1101/2021.11.26.470088 — evolutionary biology — Posted on 2021-11-26
477 Lipid droplets are required for lipid mediator production and cancer cell proliferation
Petan, T.; O. Eichmann, T.; Zimmermann, R.; Pucer Janez, A.; Gerstmeier, J.; Lambeau, G.; Jarc Jovicic, E.; Jordan, P. M.; Werz, O.; Brglez, V.
10.1101/2021.11.25.470010 — cell biology — Posted on 2021-11-26
480 An estimate of the deepest branches of the tree of life from ancient vertically-evolving genes
Moody, E. R. R.; Mahendrarajah, T. A.; Dombrowski, N.; Clark, J. W.; Petitjean, C.; Offre, P.; Szöllosi, G. J.; Spang, A.; Williams, T. A.
10.1101/2021.01.19.427276 — evolutionary biology — Posted on 2021-11-26
481 Plant host shift: The viability and persistence of a polyphagous, non-native insect
Bueno Silva, I.; McGrane-Corrigan, B.; Mason, O.; de Andrade Moral, R.; Augusto Conde Godoy, W.
10.1101/2021.09.20.461112 — ecology — Posted on 2021-11-26
482 β-catenin perturbations control differentiation programs in mouse embryonic stem cells
Pedone, E.; Failli, M.; Gambardella, G.; De Cegli, R.; La Regina, A.; di Bernardo, D.; Marucci, L.
10.1101/2020.05.15.098137 — cell biology — Posted on 2021-11-26
483 The renal inflammatory network of nephronophthisis
Quatredeniers, M.; Bienaime, F.; Ferri, G.; Isnard, P.; Poree, E.; Billot, K.; Birgy, E.; Ceccarelli, S.; Legendre, F.; Braeg, S.; Nguyen-Khoa, T.; Salomon, R.; Gubler, M.-C.; Kuehn, E. W.; Saunier, S.; Viau, A.
10.1101/2021.01.07.425719 — physiology — Posted on 2021-11-26
485 Nanopore ReCappable Sequencing maps SARS-CoV-2 5' capping sites and provides new insights into the structure of sgRNAs
Ugolini, C.; Mulroney, L.; Leger, A.; Castelli, M.; Criscuolo, E.; Kavanagh Williamson, M.; Davidson, A. D.; Almuqrin, A.; Giambruno, R.; Jain, M.; Frige, G.; Olsen, H.; Tzertzinis, G.; Schildkraut, I.; Wulf, M. F.; Correa, I. R.; Ettwiller, L.; Clementi, N.; Clementi, M.; Mancini, N.; Birney, E.; Akeson, M.; Nicassio, F.; Matthews, D. A.; Leonardi, T.
10.1101/2021.11.24.469860 — genomics — Posted on 2021-11-26
487 Markerless mouse tracking for social experiments
Le, V. A.; Sterley, T.-L.; Cheng, N.; Bains, J.; Murari, K.
10.1101/2021.10.20.464614 — bioengineering — Posted on 2021-11-26
491 Dual Effects of NV-CoV-2 Biomimetic Polymer: An Antiviral regimen against COVID-19
Chakraborty, A.; Diwan, A.; Chiniga, V.; Arora, V.; Holkar, P.; Thakur, Y.; Tatake, J.; Barton, R.; Holkar, N.; Pond, B.
10.1101/2021.11.24.469813 — pharmacology and toxicology — Posted on 2021-11-26
492 Microbiome-based disease prediction with multimodal variational information bottlenecks
Grazioli, F.; Siarheyeu, R.; Alqassem, I.; Henschel, A.; Pileggi, G.; Meiser, A.
10.1101/2021.06.08.447505 — bioinformatics — Posted on 2021-11-26
496 GwEEP - A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes
Kyriakopoulos, C.; Nordström, K.; Kramer, P. L.; Gottfreund, J.; Salhab, A.; Arand, J.; Müller, F.; von Meyenn, F.; Ficz, G.; Reik, W.; Wolf, V.; Walter, J.; Giehr, P.
10.1101/2020.08.06.236307 — genomics — Posted on 2021-11-25
500 Over 400 million years of cooperation: Untangling the chondrocranium-dermatocranium connection
Motch Perrine, S. M.; Pitirri, M. K.; Durham, E. L.; Kawasaki, M.; Zheng, H.; Chen, D. Z.; Kawasaki, K.; Richtsmeier, J. T.
10.1101/2021.11.24.469914 — developmental biology — Posted on 2021-11-25
505 A connectomic study of a petascale fragment of human cerebral cortex
Shapson-Coe, A.; Januszewski, M.; Berger, D. R.; Pope, A.; Wu, Y.; Blakely, T.; Schalek, R. L.; Li, P. H.; Wang, S.; Maitlin-Shepard, J.; Karlupia, N.; Dorkenwald, S.; Sjostedt, E.; Leavitt, L.; Lee, D.; Bailey, L.; Fitzmaurice, A.; Kar, R.; Field, B.; Wu, H.; Wagner-Carena, J.; Aley, D.; Lau, J.; Lin, Z.; Wei, D.; Pfister, H.; Peleg, A.; Jain, V.; Lichtman, J. W.
10.1101/2021.05.29.446289 — neuroscience — Posted on 2021-11-25
507 A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia
Marin-Rubio, J. L.; Heap, R. E.; Heunis, T.; Duenas, M. E.; Inns, J.; Scott, J.; Simpson, A. J.; Allan, J. M.; Blair, H.; Heidenreich, O.; Saxty, B.; Trost, M.
10.1101/2021.03.29.437557 — cancer biology — Posted on 2021-11-25
508 Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma
Kato, T.; Jenkins, R. P.; Derzsi, S.; Tozluoglu, M.; Rullan, A.; Hooper, S.; Chaleil, R. A. G.; Fu, X.; Joyce, H.; Thavaraj, S.; Bates, P. A.; Sahai, E.
10.1101/2021.11.24.469674 — cancer biology — Posted on 2021-11-25
510 Microbiome-based disease prediction with multimodal variational information bottlenecks
Grazioli, F.; Siarheyeu, R.; Alqassem, I.; Henschel, A.; Pileggi, G.; Meiser, A.
10.1101/2021.06.08.447505 — bioinformatics — Posted on 2021-11-25
514 Hotspots of pest-induced US urban tree death, 2020-2050
Hudgins, E. J.; Koch, F. H.; Ambrose, M. J.; Leung, B.
10.1101/2021.04.24.441210 — ecology — Posted on 2021-11-25
515 Development of a novel glycoengineering platform for the rapid production of conjugate vaccines.
Abouelhadid, S.; Atkins, E.; Kay, E.; Passmore, I.; North, S. J.; Lehri, B.; Hitchen, P.; Bakke, E.; Rahman, M.; Bosse, J.; Li, Y.; Terra, V. S.; Langford, P.; Dell, A.; Wren, B. W.; Cuccui, J.
10.1101/2021.11.25.470047 — microbiology — Posted on 2021-11-25
516 Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus
Voss, K.; Young, A.; Gibson-Corley, K. N.; Sewell, A. E.; Krystofiak, E.; Bashum, J. H.; Beavers, W. N.; Sugiura, A.; Skaar, E. P.; Ormseth, M. J.; Rathmell, J.
10.1101/2021.11.25.470053 — immunology — Posted on 2021-11-25
517 Spectral organ fingerprints for intraoperative tissue classification with hyperspectral imaging
Studier-Fischer, A.; Seidlitz, S.; Sellner, J.; Wiesenfarth, M.; Ayala, L.; Oezdemir, B.; Odenthal, J.; Knoedler, S.; Kowalewski, K.-F.; Haney, C. M.; Camplisson, I.; Dietrich, M.; Schmidt, K.; Salg, G.; Kenngott, H. G.; Adler, T. J.; Schreck, N.; Kopp-Schneider, A.; Maier-Hein, K.; Maier-Hein, L.; Mueller-Stich, B. P.; Nickel, F.
10.1101/2021.11.24.469943 — bioinformatics — Posted on 2021-11-25
519 Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity
Ramms, B.; Pollow, D. P.; Zhu, H.; Nora, C.; Harrington, A. R.; Omar, I.; Gordts, P.; Wortham, M.; Sander, M.
10.1101/2021.11.25.469928 — physiology — Posted on 2021-11-25
520 Deciphering heterogeneity of circulating epithelial cells in breast cancer patients
Menyailo, M. E.; Zainullina, V. R.; Tashireva, L. A.; Zolotareva, S. Y.; Gerashchenko, T. S.; Alifanov, V. V.; Savelieva, O. E.; Grigoryeva, E. S.; Tarabanovskaya, N. A.; Popova, N. O.; Khozyainova, A. A.; Choinzonov, E. L.; Cherdyntseva, N. V.; Perelmuter, V. M.; Denisov, E. V.
10.1101/2021.11.24.469962 — cancer biology — Posted on 2021-11-25
521 Centripetal nuclear shape fluctuations associate with chromatin condensation towards mitosis
Introini, V.; Kidiyoor, G. R.; Porcella, G.; Foiani, M.; Cicuta, P.; Cosentino Lagomarsino, M.
10.1101/2021.11.25.469847 — biophysics — Posted on 2021-11-25
522 On the reproductive mechanisms of Gram-positive protocells
Kanaparthi, D.; Lampe, M.; Hildebrand, F.; Boesen, T.; Klingl, A.; Phapale, P.; Lueders, T.; Schwille, P.
10.1101/2021.11.25.470039 — biophysics — Posted on 2021-11-25
524 DeepSpot: a deep neural network for RNA spot enhancement in smFISH microscopy images
Bouilhol, E.; Lefevre, E.; Dartigues, B.; Brackin, R.; Savulescu, A. F.; Nikolski, M.
10.1101/2021.11.25.469984 — bioinformatics — Posted on 2021-11-25
525 Cryo-EM structure of the Smc5/6 holo-complex
Hallett, S. T.; Campbell Harry, I.; Schellenberger, P.; Zhou, L.; Cronin, N. B.; Baxter, J.; Etheridge, T. J.; Murray, J. M.; Oliver, A. W.
10.1101/2021.11.25.470006 — biochemistry — Posted on 2021-11-25
526 High Resolution Single Cell Maps Reveals Distinct Cell Organization and Function Across Different Regions of the Human Intestine
Hickey, J. W.; Becker, W. R.; Nevins, S. A.; Horning, A. M.; Perez, A. E.; Chiu, R.; Chen, D. C.; Cotter, D.; Esplin, E. D.; Weimer, A.; Caraccio, C.; Venkataraaman, V.; Schurch, C. M.; Black, S.; Brbic, M.; Cao, K.; Leskovec, J.; Zhang, Z.; Lin, S.; Longacre, T.; Plevitis, S. K.; Lin, Y.; Nolan, G. P.; Greenleaf, W.; Snyder, M. P.
10.1101/2021.11.25.469203 — genomics — Posted on 2021-11-25
530 A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons
Reilly, L.; Peng, L.; Lara, E.; Ramos, D.; Fernandopulle, M.; Pantazis, C.; Stadler, J.; Santiana, M.; Dadu, A.; Iben, J. R.; Faghri, F.; Nalls, M. A.; Coon, S. L.; Narayan, P.; Singleton, A. B.; Cookson, M. R.; Ward, M. E.; Qi, Y. A.
10.1101/2021.11.24.469921 — neuroscience — Posted on 2021-11-25
532 Sex-specific transcriptomic and epitranscriptomic signatures of PTSD-like fear acquisition.
Reis, A. M.; Hammond, J.; Stevanovski, I.; Arnold, J.; McGregor, I.; Deveson, I. W.; Gururajan, A.
10.1101/2021.11.25.468910 — neuroscience — Posted on 2021-11-25
538 Stable and functionally diverse versatile peroxidases by computational design directly from sequence
Barber-Zucker, S.; Mindel, V.; Garcia-Ruiz, E.; Weinstein, J. J.; Alcalde, M.; Fleishman, S. J.
10.1101/2021.11.25.469886 — biochemistry — Posted on 2021-11-25
541 Population density and plant availability interplay to shape browsing intensity by roe deer in a deciduous forest
Gaudry, W.; Gaillard, J.-M.; Saïd, S.; Marell, A.; Baltzinger, C.; Rocquencourt, A.; Bonenfant, C.
10.1101/2021.11.25.468041 — ecology — Posted on 2021-11-25
542 Gut-testis axis: microbiota-(n-3) PUFA improving semen quality in type 1 diabetes
Zhao, Y.; Hao, Y.; Feng, Y.; Yan, X.; Chen, L.; Zhong, R.; Tang, X.; Shen, W.; Sun, Q.-Y.; Sun, Z.; Ren, Y.; Zhang, H.
10.1101/2021.11.24.469971 — developmental biology — Posted on 2021-11-25
547 Resting-state fMRI-based screening of deschloroclozapine in rhesus macaques predicts dosage-dependent behavioral effects
Fujimoto, A.; Elorette, C.; Fredericks, J. M.; Fujimoto, S. H.; Fleysher, L.; Rudebeck, P. H.; Russ, B. E.
10.1101/2021.11.24.469738 — neuroscience — Posted on 2021-11-25
550 Emerging Accessibility Patterns in Long Telomeric Overhangs
Shiekh, S.; Mustafa, G.; Hoque, M. E.; Yokie, E.; Portman, J. J.; Balci, H.
10.1101/2021.11.24.469879 — biophysics — Posted on 2021-11-25
551 A Complete Pedigree-Based Graph Workflow for Rare Candidate Variant Analysis
Markello, C.; Huang, C.; Rodriguez, A.; Carroll, A.; Chang, P.-C.; Eizenga, J.; Markello, T.; Haussler, D.; Paten, B.
10.1101/2021.11.24.469912 — bioinformatics — Posted on 2021-11-25
554 Precise identification of cancer cells from allelic imbalances in single cell transcriptomes
Trinh, M. K.; Pacyna, C. N.; Kildisiute, G. K.; Anderson, N. D.; Khabirova, E.; Behjati, S.; Young, M. D.
10.1101/2021.11.25.469995 — genomics — Posted on 2021-11-25
557 Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells
Koh, C. P.; Bahirvani, A. G.; Wang, C. Q.; Yokomizo, T.; Ng, C. E. L.; Du, L.; Tergaonkar, V.; Voon, D. C.-C.; Hosoi, H.; Sonoki, T.; Mok, M. M. H.; Niibori-Nambu, A.; Zhang, Y.; Perkins, A. S.; Hossain, Z.; Tenen, D. G.; Ito, Y.; Venkatesh, B.; Osato, M.
10.1101/2021.11.24.469958 — developmental biology — Posted on 2021-11-25
560 Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis
Delhermitte, J.; Tafforeau, L.; Sharma, S.; Marchand, V.; Wacheul, L.; Lattuca, R.; Desiderio, S.; Motorin, Y.; Bellefroid, E.; Lafontaine, D. L.
10.1101/2021.11.25.469989 — developmental biology — Posted on 2021-11-25
561 Identifying cell-to-cell variability in internalisation using flow cytometry
Browning, A. P.; Ansari, N.; Drovandi, C.; Johnston, A.; Simpson, M. J.; Jenner, A. L.
10.1101/2021.11.24.469957 — cell biology — Posted on 2021-11-25
565 Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis
Rivera-Lugo, R.; Deng, D.; Anaya-Sanchez, A.; Tejedor-Sanz, S.; Reyes Ruiz, V. M.; Smith, H. B.; Titov, D. V.; Sauer, J. D.; Skaar, E. P.; Ajo-Franklin, C. M.; Portnoy, D. A.; Light, S. H.
10.1101/2021.11.25.470024 — microbiology — Posted on 2021-11-25
566 A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding
Manuelyan, I.; Schmoker, A. M.; Yount, B. L.; Eisenhauer, P.; Keller, J. I.; Gold, C.; Terino, D.; Ziegler, C. M.; Alexander, J.; Driscoll, H.; Hutchinson, E.; Bhella, D.; Syme, C. D.; Widman, D. G.; Heise, M. T.; Baric, R. S.; Ballif, B. A.; Botten, J. W.
10.1101/2021.11.24.469793 — microbiology — Posted on 2021-11-25
570 A Scalable and Modular Automated Pipeline for Stitching of Large Electron Microscopy Datasets
Mahalingam, G.; Torres, R.; Kapner, D.; Trautman, E. T.; Fliss, T.; Seshamani, S.; Perlman, E.; Young, R.; Kinn, S.; Buchanan, J.; Takeno, M.; Yin, W.; Bumbarger, D. J.; Gwinn, R. P.; Nyhus, J.; Lein, E.; Smith, S. J.; Reid, C.; Khairy, K.; Saalfeld, S.; Collman, F.; Macarico da Costa, N.
10.1101/2021.11.24.469932 — neuroscience — Posted on 2021-11-25
571 Intact double stranded RNA is mobile and triggers RNAi against viral and fungal plant pathogens
Brosnan, C. A.; Sawyer, A.; Felippes, F. F.; Carroll, B. J.; Waterhouse, P. M.; Mitter, N.
10.1101/2021.11.24.469772 — plant biology — Posted on 2021-11-25
572 Day length-dependent thermal COP1 dynamics integrate conflicting seasonal cues in the control of Arabidopsis elongation
Nieto, C.; Catalan, P.; Luengo, L. M.; Legris, M.; Lopez-Salmeron, V.; Daviere, J. M.; Casal, J.; Ares, S.; Prat, S.
10.1101/2021.11.25.470009 — plant biology — Posted on 2021-11-25
573 On the reproductive mechanism of Gram-negative protocells
Kanaparthi, D.; Lampe, M.; Zhu, B.; Klingl, A.; Lueders, T.; Schwille, P.
10.1101/2021.11.25.470037 — biophysics — Posted on 2021-11-25
574 ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci
Rouhana, J. M.; Wang, J.; Eraslan, G.; Anand, S.; Hamel, A. R.; Cole, B.; Regev, A.; Aguet, F.; Ardlie, K. G.; Segre, A. V.
10.1101/2021.11.24.469720 — bioinformatics — Posted on 2021-11-25
575 Annotation of Spatially Resolved Single-cell Data with STELLAR
Brbic, M.; Cao, K.; Hickey, J. W.; Tan, Y.; Snyder, M.; Nolan, G. P.; Leskovec, J.
10.1101/2021.11.24.469947 — bioinformatics — Posted on 2021-11-25
579 Analysis of transcriptional changes associated with pubertal development
Resztak, J.; Choe, J.; Wei, J.; Bruinsma, R.; Houpt, R.; Alazizi, A.; Mair-Meijers, H.; Slatcher, R.; Zilioli, S.; Pique-Regi, R.; Luca, F.
10.1101/2021.11.24.469939 — genomics — Posted on 2021-11-25
581 Spatial charting of single cell transcriptomes in tissues
Navin, N.; Wei, R.; He, S.; Bai, S.; Sei, E.; Hu, M.; Thompson, A.; Chen, K.; Krishnamurthy, S.
10.1101/2021.11.24.469915 — genomics — Posted on 2021-11-25
585 Age-specific survival in an English Twite population.
Gkourtsouli-Antoniadou, I.; Ewing, S. R.; Hudson, G.; Pearson, M. A.; Schroeder, J.; Welch, P. E.; Wilkinson, N.; Dunning, J.
10.1101/2021.11.24.469575 — ecology — Posted on 2021-11-25
588 Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling
Manchanda, Y.; Ramchunder, Z.; Shchepinova, M. M.; Rutter, G. A.; Inoue, A.; Tate, E. W.; Jones, B.; Tomas, A.
10.1101/2021.11.24.469908 — cell biology — Posted on 2021-11-25
590 Particle-associated and free-living microbial assemblages are distinct in a permanently redox-stratified freshwater lake
Cohen, A. B.; Klepac-Ceraj, V.; Butler, K.; Weber, F.; Garber, A. I.; Christensen, L. N.; Cram, J. A.; McCormick, M. L.; Taylor, G. T.
10.1101/2021.11.24.469905 — microbiology — Posted on 2021-11-25
591 A Novel Approach Towards Less Invasive Multi 'Omics Gut Analyses: A Pilot Study
Berlinberg, A. J.; Brar, A.; Stahly, A.; Gerich, M. E.; Fennimore, B. P.; Scott, F. I.; Kuhn, K. A.
10.1101/2021.11.24.469968 — microbiology — Posted on 2021-11-25
592 A glycosylphosphatidylinositol-anchored α-amylase encoded by amyD contributes to a decrease in the molecular mass of cell wall α-1,3-glucan in Aspergillus nidulans
Miyazawa, K.; Yamashita, T.; Takeuchi, A.; Kamachi, Y.; Yoshimi, A.; Tashiro, Y.; Koizumi, A.; Yano, S.; Kasahara, S.; Sano, M.; Yamagata, Y.; Nakajima, T.; Abe, K.
10.1101/2021.11.24.469953 — microbiology — Posted on 2021-11-25
593 Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation
Hochheiser, I. V.; Behrmann, H.; Hagelueken, G.; Rodriguez-Alcazar, J. F.; Kopp, A.; Latz, E.; Behrmann, E.; Geyer, M.
10.1101/2021.11.25.470035 — immunology — Posted on 2021-11-25
599 Population-level asymmetry of the cerebral cortex: reproducibility, lifespan changes, heritability, and individual differences
Roe, J. M.; Vidal-Pineiro, D.; Amlien, I. K.; Pan, M.; Sneve, M. H.; Thiebaut de Schotten, M.; Friedrich, P.; Sha, Z.; Francks, C. H.; Wang, Y.; Walhovd, K. B.; Fjell, A. M.; Westerhausen, R.
10.1101/2021.11.25.469988 — neuroscience — Posted on 2021-11-25
600 Mesoscopic Quantification of Cortical Architecture in the Living Human Brain
Gulban, O. F.; Bollmann, S.; Huber, R.; Wagstyl, K.; Goebel, R.; Poser, B. A.; Kay, K.; Ivanov, D.
10.1101/2021.11.25.470023 — neuroscience — Posted on 2021-11-25
603 Septin-7 is indispensable for proper skeletal muscle architecture and function
Gonczi, M.; Raduly, Z.; Szabo, L.; Fodor, J.; Telek, A.; Dobrosi, N.; Balogh, N.; Szentesi, P.; Kis, G.; Antal, M.; Trencsenyi, G.; Dienes, B.; Csernoch, L.
10.1101/2021.11.24.469846 — physiology — Posted on 2021-11-25
605 Long-Range Electrostatic Interactions Significantly Modulate the Affinity of Dynein for Microtubules
Pabbathi, A.; Coleman, L.; Godar, S.; Paul, A.; Garlapati, A.; Spencer, M.; Eller, J.; Alper, J. D.
10.1101/2021.11.24.469892 — biophysics — Posted on 2021-11-25
608 High-throughput tuning of ovarian cancer spheroids for on-chip invasion assays
Chen, C.; He, Y.; Lopez, E.; Carreiras, F.; Yamada, A.; Schanne Klein, M. C.; Lambert, A.; Chen, Y.; Aime, C.
10.1101/2021.11.24.469887 — bioengineering — Posted on 2021-11-25
610 An exploratory study of EEG connectivity during the first year of life in preterm and full-term infants
Gonzalez-Moreira, E.; Paz-Linares, D.; Cubero-Rego, L.; Areces-Gonzalez, A.; Valdes-Sosa, P. A.; Harmony, T.
10.1101/2021.11.24.469864 — neuroscience — Posted on 2021-11-25
611 Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease
Yeap, J.; Sathyaprakash, C.; Toombs, J.; Tulloch, J.; Scutariu, C.; Rose, J.; Burr, K.; Davies, C.; Colom-Cadena, M.; Chandran, S.; Large, C. H.; Rowan, M. J.; Gunthorpe, M. J.; Spires-Jones, T. L.
10.1101/2021.11.24.469829 — neuroscience — Posted on 2021-11-25
615 The PAIR-R24M Dataset for Multi-animal 3D Pose Estimation
Marshall, J. D.; Klibaite, U.; Gellis, A. J.; Aldarondo, D. E.; Olveczky, B. P.; Dunn, T. W.
10.1101/2021.11.23.469743 — animal behavior and cognition — Posted on 2021-11-25
616 Evidence of positive and negative selection associated with DNA methylation
Hatcher, C.; Genetics of DNA Methylation Consortium, ; Hemani, G.; Rodriguez, S.; Gaunt, T. R.; Lawson, D. J.; Min, J. L.
10.1101/2021.11.25.469994 — genetics — Posted on 2021-11-25
617 A Unified Genomic Mechanism of Cell-Fate Change
Tsuchiya, M.; Giuliani, A.; Zimatore, G.; Erenpreisa, J.; Yoshikawa, K.
10.1101/2021.11.24.469848 — cell biology — Posted on 2021-11-25
618 Non-invasive real-time access to spatial attention information from 3T fMRI BOLD signals
Loriette, C.; De Sousa Ferreira, C.; Clavagnier, S.; Lamberton, F.; Ibarrola, D.; Ben Hamed, S.
10.1101/2021.11.24.469873 — neuroscience — Posted on 2021-11-25
619 Consequences of human Tau aggregation in the hippocampal formation of ageing mice in vivo
Viney, T. J.; Sarkany, B.; Ozdemir, A. T.; Hartwich, K.; Schweimer, J.; Bannerman, D.; Somogyi, P.
10.1101/2021.11.24.469849 — neuroscience — Posted on 2021-11-25
620 Association between plasma phospho-tau181 and cognitive change from age 73 to 82: Lothian Birth Cohort 1936
Saunders, T. S.; Heslegrave, A.; King, D.; Harris, S.; Ritchie, C. W.; Muniz-Terrera, G.; Deary, I. J.; Cox, S. R.; Zetterberg, H.; Spires-Jones, T.
10.1101/2021.11.24.469836 — neuroscience — Posted on 2021-11-25
621 Generation of Infant-dedicated Fine-grained Functional Parcellation Maps of Cerebral Cortex
Wang, F.; UNC/UMN Baby Connectome Project Consortium, ; Zhang, H.; Wu, Z.; Hu, D.; Zhou, Z.; Wang, L.; Lin, W.; Li, G.
10.1101/2021.11.24.469844 — neuroscience — Posted on 2021-11-25
623 Prefrontal, striatal, and VTA subnetwork dynamics during novelty and exploration
Dede, A. J.; Marzban, N.; Mishra, A.; Reichert, R.; Anderson, P. M.; Cohen, M. X.
10.1101/2021.11.24.469851 — neuroscience — Posted on 2021-11-25
625 Number of detected proteins as the function of the sensitivity of proteomic technology in human liver cells
Vavilov, N. E.; Ilgisonis, E. V.; Lisitsa, A. V.; Ponomarenko, E. A.; Farafonova, T. E.; Tikhonova, O. V.; Zgoda, V. G.; Archakov, A. I.
10.1101/2021.11.24.469687 — systems biology — Posted on 2021-11-25
626 Non-Invasive Skin Sampling Detects Systemically Administered Drugs in Humans
Panitchpakdi, M.; Weldon, K. C.; Jarmusch, A. K.; Gentry, E. C.; Choi, A.; Sepulveda, Y.; Aguirre, S.; Sun, K.; Momper, J. D.; Dorrestein, P. C.; Tsunoda, S. M.
10.1101/2021.11.22.469638 — pharmacology and toxicology — Posted on 2021-11-25
628 Hidden structure in disordered proteins is adaptive to intracellular changes
Moses, D.; Guadalupe, K.; Yu, F.; Flores, E.; Perez, A.; McAnelly, R. L.; Shamoon, N. M.; Cuevas-Zepeda, E.; Merg, A.; Martin, E. W.; Holehouse, A. S.; Sukenik, S.
10.1101/2021.11.24.469609 — biophysics — Posted on 2021-11-25
630 A comprehensive LFQ benchmark dataset on modern day acquisition strategies in proteomics
Van Puyvelde, B.; Daled, S.; Willems, S.; Gabriels, R.; Gonzalez de Peredo, A.; Chaoui, K.; Mouton-Barbosa, E.; Bouyssie, D.; Boonen, K.; Hughes, C.; Gethings, L.; Perez-Riverol, Y.; Schiltz, O.; Martens, L.; Deforce, D.; Dhaenens, M.
10.1101/2021.11.24.469852 — bioinformatics — Posted on 2021-11-25
632 Generalizable approaches for genomic prediction of metabolites in plants
Brzozowski, L. J.; Campbell, M. T.; Hu, H.; Caffe, M.; Guterrez, L.; Smith, K. P.; Sorrells, M. E.; Gore, M. A.; Janninck, J.-L.
10.1101/2021.11.24.469870 — genomics — Posted on 2021-11-25
636 Mapping of morpho-electric features to molecular identity of cortical inhibitory neurons
Roussel, Y.; Veraszto, C.; Rodarie, D.; Damart, T.; Reimann, M. W.; Ramaswamy, S.; Markram, H.; Keller, D.
10.1101/2021.11.24.469815 — neuroscience — Posted on 2021-11-25
637 FAMOSS, a conserved 41-aa peptide involved in plant tip growth regulation
Mamaeva, A.; Kniazev, A.; Sedlov, I.; Golub, N.; Kharlampieva, D.; Manuvera, V.; Rakitin, V.; Nosov, A.; Fomenkov, A.; Pavlyukov, M.; Kovalchuk, S.; Ziganshin, R.; Glushkevich, A.; Lazarev, V.; Fesenko, I.
10.1101/2021.11.24.469821 — plant biology — Posted on 2021-11-25
641 Genome size evolution in the diverse insect order Trichoptera
Heckenhauer, J.; Frandsen, P. B.; Sproul, J. S.; Li, Z.; Paule, J.; Larracuente, A. M.; Maughan, P. J.; Barker, M. S.; Schneider, J. V.; Stewart, R. J.; Pauls, S. U.
10.1101/2021.05.10.443368 — evolutionary biology — Posted on 2021-11-25
642 Nuclear Pore Complex Acetylation Regulates mRNA Export and Cell Cycle Commitment in Budding Yeast
Gomar-Alba, M.; Pozharskaia, V.; Schaal, C.; Kumar, A.; Jacquel, B.; Charvin, G.; Igual, J. C.; Mendoza, M.
10.1101/2021.09.01.458533 — cell biology — Posted on 2021-11-25
643 Waffle Method: A general and flexible approach for FIB-milling small and anisotropically oriented samples
Kelley, K.; Raczkowski, A. M.; Klykov, O.; Jaroenlak, P.; Bobe, D.; Kopylov, M.; Eng, E. T.; Bhabha, G.; Potter, C. S.; Carragher, B.; Noble, A. J.
10.1101/2020.10.28.359372 — microbiology — Posted on 2021-11-25
644 High prevalence of Klebsiella pneumoniae in European food products: a multicentric study comparing culture and molecular detection methods
Rodrigues, C.; Hauser, K.; Cahill, N.; Ligowska-Marzeta, M.; Centorotola, G.; Cornacchia, A.; Garcia Fierro, R.; Haenni, M.; Moller Nielsen, E.; Piveteau, P.; Barbier, E.; Morris, D.; Pomilio, F.; Brisse, S.
10.1101/2021.11.24.469859 — microbiology — Posted on 2021-11-25
645 Mutant huntingtin actively crosses neuromuscular synapses and causes transmission-selective pathology in human myotubes
Dinamarca Ceballos, M.; Colombo, L.; Brykczynska, U.; Grimm, A.; Tousiaki, E. N.; Fruh, I.; Hossain, I.; Gabriel, D.; Eckert, A.; Mueller, M.; Pecho-Vrieseling, E.
10.1101/2021.07.28.454044 — neuroscience — Posted on 2021-11-25
646 Mouse frontal cortex mediates additive multisensory decisions
Coen, P.; Sit, T. P.; Wells, M. J.; Carandini, M.; Harris, K. D.
10.1101/2021.04.26.441250 — neuroscience — Posted on 2021-11-25
648 Microbiome-based disease prediction with multimodal variational information bottlenecks
Grazioli, F.; Siarheyeu, R.; Alqassem, I.; Henschel, A.; Pileggi, G.; Meiser, A.
10.1101/2021.06.08.447505 — bioinformatics — Posted on 2021-11-25
652 Plant host shift: The viability and persistence of a polyphagous, non-native insect
Bueno Silva, I.; McGrane-Corrigan, B.; Mason, O.; de Andrade Moral, R.; Augusto Conde Godoy, W.
10.1101/2021.09.20.461112 — ecology — Posted on 2021-11-25
653 The Gut Microbiome of Exudivorous Marmosets in the Wild and Captivity
Malukiewicz, J.; Cartwright, R. A.; Dergam, J. A.; Igayara, C. S.; Kessler, S.; Moreira, S. B.; Nash, L. T.; Nicola, P. A.; Pereira, L. C. M.; Pissinati, A.; Ruiz-Miranda, C. R.; Ozga, A. T.; Quirino, A. A.; Roos, C.; Silva, D. L.; Stone, A. C.; Grativol, A. D.
10.1101/708255 — microbiology — Posted on 2021-11-25
654 Elevation of TRPV1 expression on T cells during experimental immunosuppression
Kumar, P. S.; Mukherjee, T.; Khamaru, S.; Radhakrishnan, A.; Kishore, D. J. N.; Chawla, S.; Sahoo, S. S.; Chattopadhyay, S.
10.1101/2021.03.04.434013 — immunology — Posted on 2021-11-25
656 Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration
Marsay, K. S.; Greaves, S.; Mahabaleshwar, H.; Ho Min, C.; Roehl, H.; Monk, P. N.; Carney, T. J.; Partridge, L. J.
10.1101/2021.05.19.444012 — developmental biology — Posted on 2021-11-25
657 Host Species is Linked to Pathogen Genotype for the Amphibian Chytrid Fungus (Batrachochytrium dendrobatidis)
Byrne, A. Q.; Waddle, A. W.; Saenz, V.; Ohmer, M.; Jaeger, J. R.; Richards-Zawacki, C. L.; Voyles, J.; Rosenblum, E. B.
10.1101/2021.11.24.469827 — molecular biology — Posted on 2021-11-24
658 Transcriptional expression changes during compensatory plasticity in the prothoracic ganglion of the adult cricket Gryllus bimaculatus
Wang, F.; Fisher, H.; Ledwidge, L.; O'Brien, J.; Kingston, S.; Beckman, J.; Johnson, J.; Miranda Portillo, L.; Al Musawi, T.; Rubenstein, A.; Michaelson, D.; Horch, H. W.
10.1101/2021.11.24.469824 — neuroscience — Posted on 2021-11-24
659 A community-developed extension to Darwin Core for reporting the chronometric age of specimens
Brenskelle, L.; Wieczorek, J.; Davis, E.; Emery, K.; Wallis, N. J.; LeFebvre, M. J.; Guralnick, R.
10.1101/2021.11.24.469822 — paleontology — Posted on 2021-11-24
661 Multivariate Characterization of Morpho-biometric Traits of Indigenous Helmeted Guinea Fowl (Numida meleagris) in Nigeria
Yakubu, A.; Jegede, P.; Wheto, M.; Shoyombo, A.; Adebambo, A. O.; Popoola, M. A.; Osaiyuwu, O. H.; Olafadehan, O. A.; Alabi, O. O.; Ukim, C. I.; Vincent, S. T.; Mundi, H. L.; Olayanju, A.; Adebambo, O. A.
10.1101/2021.11.24.469826 — genetics — Posted on 2021-11-24
662 Global non-random abundance of short tandem repeats in rodents and primates.
Arabfard, M.; Salesi, M.; Hassani Nourian, Y.; Arabipour, I.; Ali Maddi, A. M.; Kavousi, K.; Ohadi, M.
10.1101/2021.11.24.469825 — evolutionary biology — Posted on 2021-11-24
663 Estrogen-related receptor alpha and Rplp1-dependent translation coordinately regulate starvation response and decrease NASH progression
Tripathi, M.; Gauthier, K.; Sandireddy, R.; Zhou, J.; Tikno, K.; Arul, K.; Park, S.-H.; Wu, Y.; Bay, B. H.; Giguere, V.; Chow, P. K. H.; McDonnell, D. P.; Yen, P. M.; Singh, B. K.
10.1101/2021.11.16.468891 — molecular biology — Posted on 2021-11-24
664 BATL: Bayesian annotations for targeted lipidomics
Chitpin, J. G.; Surendra, A.; Nguyen, T. T.; Taylor, G. P.; Xu, H.; Alecu, I.; Ortega, R.; Tomlinson, J. J.; Crawley, A. M.; McGuinty, M.; Schlossmacher, M. G.; Saunders-Pullman, R.; Cuperlovic-Culf, M.; Bennett, S. A. L.; Perkins, T. J.
10.1101/2021.03.18.435788 — bioinformatics — Posted on 2021-11-24
665 The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
Kleinova, R.; Leuchtenberger, A. F.; Lo Giudice, C.; Tanzer, A.; Derdak, S.; Picardi, E.; Jantsch, M. F.
10.1101/2021.11.24.469911 — genomics — Posted on 2021-11-24
666 Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice
Brenneman, K. V.; Li, X.; Kumar, S.; Delgado, E.; Checkley, L. A.; Shoue, D. A.; Reyes, A.; Abatiyow, B.; Haile, M.; Tripura, R.; Peto, T.; Lek, D.; Button-Simons, K. A.; Kappe, S. H. I.; Dhorda, M.; Nosten, F.; Nkhoma, S. C.; Cheeseman, I. H.; Vaughan, A. M.; Ferdig, M. T.; Anderson, T. J.
10.1101/2021.11.24.469878 — genomics — Posted on 2021-11-24
667 Evolutionary features of a prolific subtype of avian influenza A virus in European waterfowl
Wille, M.; Tolf, C.; Latorre-Margalef, N.; Fouchier, R. A. M.; Halpin, R. A.; Wentworth, D. E.; Ragwani, J.; Pybus, O. G.; Olsen, B.; Waldenstrom, J.
10.1101/2021.11.24.469925 — evolutionary biology — Posted on 2021-11-24
669 Fast surveillance response and genome sequencing reveals the circulation of a new Yellow Fever Virus sublineage in 2021, in Minas Gerais, Brazil
Andrade, M. S.; Campos, F. S.; Oliveira, C. H.; Oliveira, R. S.; Campos, A. A. S.; Almeida, M. A. B. d.; Teixeira, D. S.; Seva, A. d. P.; Temponi, A. d. O. D.; Magalhaes, F. M.; Chaves, D. C. C.; Pereira, M. A.; Lamounier, L. O.; Menezes, G. G. d.; Aquino-Teixeira, S. M.; Goncalves-dos-Santos, M. E.; Bernal-Valle, S.; Muller, N. F. D.; Cardoso, J. d. C.; Santos, E. d.; Mares-Guia, M. A.; Albuquerque, G. R.; Romano, A. P. M.; Franco, A. C.; Ribeiro, B. M.; Roehe, P. M.; Abreu, F. V. S. d.
10.1101/2021.11.24.469129 — molecular biology — Posted on 2021-11-24
670 High prevalence of Klebsiella pneumoniae in European food products: a multicentric study comparing culture and molecular detection methods
Rodrigues, C.; Hauser, K.; Cahill, N.; Ligowska-Marzeta, M.; Centorotola, G.; Cornacchia, A.; Garcia Fierro, R.; Haenni, M.; Moller Nielsen, E.; Piveteau, P.; Barbier, E.; Morris, D.; Pomilio, F.; Brisse, S.
10.1101/2021.11.24.469859 — microbiology — Posted on 2021-11-24
671 SARS-CoV-2 variants of concern Alpha, Beta, Gamma and Delta have extended ACE2 receptor host-ranges
Thakur, N.; Gallo, G.; Newman, J.; Peacock, T. P.; Biasetti, L.; Hall, C. N.; Wright, E.; Barclay, W.; Bailey, D.
10.1101/2021.11.23.469663 — microbiology — Posted on 2021-11-24
672 Proteomic analysis of metabolic pathways supports chloroplast-mitochondria cross-talk in a Cu-limited diatom
Hippmann, A.; Schuback, N.; Moon, K.-M.; McCrow, J. P.; Allen, A. E.; Foster, L. J.; Green, B. R.; Maldonado, M. T.
10.1101/2020.09.15.298752 — microbiology — Posted on 2021-11-24
674 Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages
D'Rozario, J.; Knoblich, K.; Luetge, M.; Perez Shibayama, C.; Cheng, H.-W.; Alexandre, Y. O.; Roberts, D.; Campos, J.; Astarita, J.; Dutton, E.; Suliman, M.; Denton, A. E.; Turley, S. J.; Boyd, R. L.; Mueller, S.; Ludewig, B.; Heng, T.; Fletcher, A. L.
10.1101/2021.11.24.469855 — immunology — Posted on 2021-11-24
675 MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors
Urbanski, L.; Brugiolo, M.; Park, S.; Angarola, B. L.; Leclair, N. K.; Palmer, P.; Sahu, S. K.; Anczukow, O.
10.1101/2021.11.24.469558 — cancer biology — Posted on 2021-11-24
677 Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19
Islam, S.; Charnley, M.; Bindra, G.; Ratcliffe, J.; Zhou, J.; Mezzenga, R.; Hulett, M. D.; Han, K.; Berryman, J. T.; Reynolds, N. P.
10.1101/2021.11.24.469537 — biochemistry — Posted on 2021-11-24
678 Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures
Ruberto, A. A.; Bourke, C.; Vantaux, A.; Maher, S. P.; Jex, A.; Witkowski, B.; Snounou, G.; Mueller, I.
10.1101/2021.11.24.469176 — genomics — Posted on 2021-11-24
680 Synchrony and idiosyncrasy in the gut microbiome of wild primates
Bjork, J. R.; Dasari, M. R.; Roche, K.; Grieneisen, L.; Gould, T. J.; Grenier, J.-C.; Yotova, V.; Gottel, N.; Jansen, D.; Gesquiere, L. R.; Gordon, J. B.; Learn, N. H.; Wango, T. L.; Mututua, R. S.; Warutere, J. K.; Siodi, L. i.; Mukherjee, S.; Barreiro, L. B.; Alberts, S. C.; Gilbert, J. A.; Tung, J.; Blekhman, R.; Archie, E.
10.1101/2021.11.24.469913 — ecology — Posted on 2021-11-24
681 Long-term culture system for deep-sea mussels Gigantidas childressi
Hiebenthal, C.; Gehlert, F.-O.; Schmidt, M.; Reusch, T. B. H.; Melzner, F.
10.1101/2021.11.24.469854 — ecology — Posted on 2021-11-24
682 Vertebrate hemicentin-1 interacts physically and genetically with nidogen-2
Zhang, J.-L.; Richetti, S.; Ramezani, T.; Welcker, D.; Luetke, S.; Pogoda, H.-M.; Hatzold, J.; Zaucke, F.; Keene, D. R.; Bloch, W.; Sengle, G.; Hammerschmidt, M.
10.1101/2021.11.24.469833 — developmental biology — Posted on 2021-11-24
683 RyR2/IRBIT regulates insulin gene transcription, insulin content, and secretion in the insulinoma cell line INS-1
Harvey, K. E.; LaVigne, E. K.; Dar, M. S.; Pratt, E. P. S.; Salyer, A. E.; Sample, P. A.; Aryal, U. K.; Gowher, H.; Hockerman, G. H.
10.1101/2021.11.24.469894 — cell biology — Posted on 2021-11-24
686 Antiviral activity of molnupiravir precursor NHC against Variants of Concern (VOCs) and its therapeutic window in a human lung cell model
Prince, T.; Donovan-Banfield, I.; Goldswain, H.; Penrice-Randal, R.; Turtle, L.; Fletcher, T.; Khoo, S.; Hiscox, J. A.
10.1101/2021.11.23.469695 — microbiology — Posted on 2021-11-24
687 LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans
Song, J.; Chow, R. D.; Pena-Hernandez, M.; Zhang, L.; Loeb, S. A.; So, E.-Y.; Liang, O. D.; Wilen, C. B.; Lee, S.
10.1101/2021.11.23.469714 — microbiology — Posted on 2021-11-24
693 Characterization of the immune resistance of SARS-CoV-2 Mu variant and the immunity induced by Mu infection
Uriu, K.; Cardenas, P.; Munoz, E.; Barragan, V.; Kosugi, Y.; Shirakawa, K.; Takaori-Kondo, A.; Ecuador-COVID19 Consortium, ; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Sato, K.
10.1101/2021.11.23.469770 — microbiology — Posted on 2021-11-24
694 Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
Chen, Y.; Sun, L.; Ullah, I.; Beaudoin-Bussieres, G.; Anand, S. P.; Hederman, A. P.; Tolbert, W. D.; Sherburn, R.; Nguyen, D. N.; Marchitto, L.; Ding, S.; Wu, D.; Luo, Y.; Gottumukkala, S.; Moran, S.; Kumar, P.; Piszczek, G.; Mothes, W.; Ackerman, M. E.; Finzi, A. E.; Uchil, P. D.; Gonzalez, F. J.; Pazgier, M.
10.1101/2021.11.24.469776 — microbiology — Posted on 2021-11-24
696 Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern
Favorskaya, I. A.; Shcheblyakov, D. V.; Esmagambetov, I. B.; Dolzhikova, I. V.; Alekseeva, I. A.; Korobkova, A. I.; Voronina, D. V.; Ryabova, E. I.; Derkaev, A. A.; Kovyrshina, A. V.; Iliukhina, A. A.; Botikov, A. G.; Voronina, O. L.; Egorova, D. A.; Zubkova, O. V.; Ryzhova, N. N.; Aksenova, E. I.; Kunda, M. S.; Logunov, D. Y.; Naroditsky, B. S.; Gintsburg, A. L.
10.1101/2021.11.24.469842 — immunology — Posted on 2021-11-24
697 Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19
van der Sluis, R. M.; Cham, L. B.; Oliver, A. G.; Gammelgaard, K. R.; Pedersen, J. G.; Idorn, M.; Ahmodov, U.; Hernandez, S. S.; Cemalovic, E.; Godsk, S. H.; Thyrsted, J.; Gunst, J. D.; Nielsen, S. D.; Jorgensen, J. j.; Bjerg, T. W.; Laustsen, A.; Reinert, L.; Olagnier, D.; Bak, R. O.; Kjolby, M.; Holm, C. K.; Tolstrup, M.; Paludan, S. R.; Kristensen, l. S.; Sogaard, O. S.; Jakobsen, M. R.
10.1101/2021.11.23.469755 — immunology — Posted on 2021-11-24
699 Atazanavir is a competitive inhibitor of SARS-CoV-2 Mpro, impairing variants replication in vitro and in vivo
Chaves, O. A.; Sacramento, C. Q.; Ferreira, A. C.; Mattos, M.; Fintelman-Rodrigues, N.; Temerozo, J. R.; Pinto, D. P.; da Silveira, G. P. E.; da Fonseca, L. B.; Pereira, H. M.; Carlos, A. S.; d'Avila, J. d. C. P.; Viola, J. P. B.; Monteiro, R. Q.; Vazquez, L.; Bozza, P. T.; Castro-Faria-Neto, H. C.; Souza, T. M. L.
10.1101/2021.11.24.469775 — pharmacology and toxicology — Posted on 2021-11-24
701 Dynamic subcortical modulators of human default mode network function
Harrison, B. J.; Davey, C. G.; Savage, H. S.; Jamieson, A. J.; Leonards, C. A.; Moffat, B. A.; Glarin, R. K.; Steward, T.
10.1101/2021.10.27.466172 — neuroscience — Posted on 2021-11-24
703 Fidelity varies in the symbiosis between a gutless marine worm and its microbial consortium
Sato, Y.; Wippler, J.; Wentrup, C.; Ansorge, R.; Sadowski, M.; Gruber-Vodicka, H. R.; Dubilier, N.; Kleiner, M.
10.1101/2021.01.30.428904 — microbiology — Posted on 2021-11-24
705 Spatial organization of nuclear pores in Xenopus laevis oocytes
Ravazzano, L.; Bonfanti, S.; Guerra, R.; Montel, F.; La Porta, C. A. M.; Zapperi, S.
10.1101/2021.09.01.458492 — biophysics — Posted on 2021-11-24
708 Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis
Popova, J. V.; Pavlova, G. A.; Razuvaeva, A. V.; Yarinich, L. A.; Andreyeva, E. N.; Anders, A. F.; Galimova, Y.; Renda, F.; Somma, M. P.; Pindyurin, A. V.; Gatti, M.
10.1101/2021.11.19.469214 — genetics — Posted on 2021-11-24
709 A NANOG-pERK reciprocal regulatory circuit mediates Nanog autoregulation and ERK signaling dynamics.
Kale, H. T.; Rajpurohit, R. S.; Jana, D.; Vijay, V. V.; Srivastava, M.; Mourya, P. R.; Srinivas, G.; Shekar, P. C.
10.1101/2021.06.28.450121 — cell biology — Posted on 2021-11-24
710 Beamforming seizures from the temporal lobe
Garcia Dominguez, L.; Tarazi, A.; Valiante, T.; Wennberg, R.
10.1101/2021.11.19.469291 — neuroscience — Posted on 2021-11-24
713 The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis
Jiang, J.; Zhang, Z.; Hu, Q.; Zhu, Y.; Gao, Z.; Shang, E.; Liu, G.; Liu, W.; Hu, R.; Chong, X.; Guan, Z.; Fang, W.; Chen, S.; Sun, B.; He, Y.; Chen, F.
10.1101/2021.11.23.469726 — plant biology — Posted on 2021-11-24
714 A community-developed extension to Darwin Core for reporting the chronometric age of specimens
Brenskelle, L.; Wieczorek, J.; Davis, E.; Emery, K.; Wallis, N. J.; LeFebvre, M. J.; Guralnick, R.
10.1101/2021.11.24.469822 — paleontology — Posted on 2021-11-24
715 Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production
Perrault, E. N.; Shireman, J. M.; Ali, E. S.; Preddy, I.; Lin, P.; Park, C.; Tomes, L.; Zolp, A. J.; Budhiraja, S.; Baisiwala, S.; James, C. D.; Ben-Sahra, I.; Pott, S.; Basu, A.; Ahmed, A. U.
10.1101/2021.11.23.469785 — cancer biology — Posted on 2021-11-24
718 Rare alternative second line injectable drug resistance markers identified by gene-wise genome wide association in M. tuberculosis with unexplained resistance
Conkle-Gutierrez, D. V.; Kim, C.; Ramirez-Busby, S. M.; Modlin, S. J.; Mansjö, M.; Werngren, J.; Rigouts, L.; Hoffner, S.; Valafar, F.
10.1101/2021.11.23.469801 — genomics — Posted on 2021-11-24
719 Genome assembly of the JD17 soybean provides a new reference genome for Comparative genomics
Yi, X.; Liu, J.; Chen, S.; Wu, H.; Liu, M.; Xu, Q.; Lei, L.; Zhang, B.; Fan, W.; Kudrna, D.; Lee, S.; Wing, R. A.; Yang, C.; Zhang, M.; Zhang, J.; Wang, X.; Chen, N.
10.1101/2021.11.23.469778 — genomics — Posted on 2021-11-24
720 Multivariate Characterization of Morpho-biometric Traits of Indigenous Helmeted Guinea Fowl (Numida meleagris) in Nigeria
Yakubu, A.; Jegede, P.; Wheto, M.; Shoyombo, A.; Adebambo, A. O.; Popoola, M. A.; Osaiyuwu, O. H.; Olafadehan, O. A.; Alabi, O. O.; Ukim, C. I.; Vincent, S. T.; Mundi, H. L.; Olayanju, A.; Adebambo, O. A.
10.1101/2021.11.24.469826 — genetics — Posted on 2021-11-24
722 Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution
Amicone, M.; Borges, V.; Alves, M. J.; Isidro, J.; Ze-Ze, L.; Duarte, S.; Vieira, L.; Guiomar, R.; Gomes, J. P.; Gordo, I.
10.1101/2021.05.19.444774 — evolutionary biology — Posted on 2021-11-24
723 Mutators drive evolution of multi-resistance to antibiotics
Gifford, D. R.; Berrios-Caro, E.; Joerres, C.; Sune, M.; Galla, T.; Knight, C. G.
10.1101/643585 — evolutionary biology — Posted on 2021-11-24
724 Global non-random abundance of short tandem repeats in rodents and primates.
Arabfard, M.; Salesi, M.; Hassani Nourian, Y.; Arabipour, I.; Ali Maddi, A. M.; Kavousi, K.; Ohadi, M.
10.1101/2021.11.24.469825 — evolutionary biology — Posted on 2021-11-24
725 SELENOT deficiency alters projection neuron migration during corticogenesis in mice
Carpentier, E.; Falluel-Morel, A.; Brunet, L.; Benard, M.; Godefroy, D.; Boukhzar, L.; Arabo, A.; Anouar, Y.
10.1101/2021.11.23.469805 — developmental biology — Posted on 2021-11-24
726 Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells
Zhang, C.; Han, X.; Liu, J.; Chen, L.; Lei, Y.; Chen, K.; Si, J.; Wang, T.-y.; Zhou, H.; Zhao, X.; Zhang, X.; An, Y.; Li, Y.; Wang, Q.-f.
10.1101/2021.11.24.469676 — cell biology — Posted on 2021-11-24
727 A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
Merchant, M. K.; Mata, C. P.; Liu, Y.; Zhai, H.; Protasio, A. V.; Modis, Y.
10.1101/2021.11.23.469668 — molecular biology — Posted on 2021-11-24
728 Host Species is Linked to Pathogen Genotype for the Amphibian Chytrid Fungus (Batrachochytrium dendrobatidis)
Byrne, A. Q.; Waddle, A. W.; Saenz, V.; Ohmer, M.; Jaeger, J. R.; Richards-Zawacki, C. L.; Voyles, J.; Rosenblum, E. B.
10.1101/2021.11.24.469827 — molecular biology — Posted on 2021-11-24
732 Impaired astrocytic Ca2+ signalling in awake Alzheimer's disease transgenic mice
Abjorsbraten, K. S.; Skaaraas, G. H. E. S.; Cunen, C.; Bjornstad, D. M.; Binder, K. M. G.; Jensen, V.; Nilsson, L. N.; Rao, S. B.; Tang, W.; Hermansen, G. H.; Nagelhus, E. A.; Ottersen, O. P.; Torp, R.; Enger, R.
10.1101/2021.11.21.469461 — neuroscience — Posted on 2021-11-24
733 Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract
Porat, S.; Sibilia, F.; Yoon, J.; Shi, Y.; Dahl, M. J.; Werkle-Bergner, M.; Duzel, S.; Bodammer, N.; Lindenberger, U.; Kuhn, S.; Mather, M.
10.1101/2021.11.23.469621 — neuroscience — Posted on 2021-11-24
734 Transcriptional expression changes during compensatory plasticity in the prothoracic ganglion of the adult cricket Gryllus bimaculatus
Wang, F.; Fisher, H.; Ledwidge, L.; O'Brien, J.; Kingston, S.; Beckman, J.; Johnson, J.; Miranda Portillo, L.; Al Musawi, T.; Rubenstein, A.; Michaelson, D.; Horch, H. W.
10.1101/2021.11.24.469824 — neuroscience — Posted on 2021-11-24
736 Characterization of the grape powdery mildew genetic resistance loci in Muscadinia rotundifolia Trayshed
Massonnet, M.; Vondras, A. M.; Cochetel, N.; Riaz, S.; Pap, D.; Minio, A.; Figueroa-Balderas, R.; Walker, M. A.; Cantu, D.
10.1101/2021.11.23.469029 — plant biology — Posted on 2021-11-24
737 A chromosome-level reference genome of Ensete glaucum gives insight into diversity, chromosomal and repetitive sequence evolution in the Musaceae
Wang, Z.; Rouard, M.; Biswas, M. K.; Droc, G.; Cui, D.; Roux, N.; Baurens, F.-C.; Ge, X.-J.; Schwarzacher, T.; Heslop-Harrison, J.; Liu, Q.
10.1101/2021.11.23.469474 — plant biology — Posted on 2021-11-24
740 Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma
Kato, T.; Jenkins, R. P.; Derzsi, S.; Tozluoglu, M.; Rullan, A.; Hooper, S.; Chaleil, R. A. G.; Fu, X.; Joyce, H.; Thavaraj, S.; Bates, P. A.; Sahai, E.
10.1101/2021.11.24.469674 — cancer biology — Posted on 2021-11-24
741 SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction
Huang, Y.; Harris, B. S.; Minami, S. A.; Jung, S.; Shah, P.; Nandi, S.; McDonald, K.; Faller, R.
10.1101/2021.07.15.452507 — biophysics — Posted on 2021-11-24
743 Vocal markers of Autism Spectrum Disorder: assessing the generalizability of machine learning models
Rybner, A.; Jessen, E. T.; Mortensen, M. D.; Larsen, S. N.; Grossman, R.; Bilenberg, N.; Cantio, C.; Jepsen, J. R. M.; Weed, E.; Simonsen, A.; Fusaroli, R.
10.1101/2021.11.22.469538 — bioinformatics — Posted on 2021-11-24
745 Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease
Johnson, T. S.; Yu, C. Y.; Huang, Z.; Xu, S.; Wang, T.; Dong, C.; Shao, W.; Abu Zaid, M.; Huang, X.; Wang, Y.; Bartlett, C.; Zhang, Y.; Walker, B.; Liu, Y.; Zhang, J.; Huang, K.
10.1101/2020.06.16.142984 — bioinformatics — Posted on 2021-11-24
747 Directed Evolution of Aptamer Discovery Technologies
Wu, D.; Gordon, C.; Shin, J.; Eisenstein, M.; Soh, H. T.
10.1101/2021.11.23.469732 — bioengineering — Posted on 2021-11-24
749 Parent-offspring inference in inbred populations
Runge, J.-N.; König, B.; Lindholm, A. K.; Bendesky, A.
10.1101/2021.11.23.469656 — genetics — Posted on 2021-11-24
751 A protease-activatable luminescent biosensor andreporter cell line for authentic SARS-CoV-2 infection
Pereyra Gerber, P.; Duncan, L. M.; Greenwood, E. J.; Marelli, S.; Naamati, A.; Teixeira-Silva, A.; Crozier, T. W.; Gabaev, I.; Zhan, J. R.; Mulroney, T. E.; Horner, E. C.; Doffinger, R.; Willis, A. E.; Thanventhiran, J. E.; Protasio, A. V.; Matheson, N. J.
10.1101/2021.03.22.435957 — microbiology — Posted on 2021-11-24
752 Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5
Buscham, T. J.; Eichel-Vogel, M. A.; Steyer, A. M.; Jahn, O.; Strenzke, N.; Dardawal, R.; Memhave, T. R.; Siems, S. B.; Müller, C.; Meschkat, M.; Sun, T.; Ruhwedel, T.; Möbius, W.; Krämer-Albers, E.-M.; Boretius, S.; Nave, K.-A.; Werner, H. B.
10.1101/2021.11.22.469514 — neuroscience — Posted on 2021-11-24
754 Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges
Song, K.; Minami, J. K.; Crosson, W. P.; Salazar, J.; Pazol, E.; Senaratne, N. T.; Rao, N.; Paraiso, K.; Graeber, T. G.
10.1101/2021.11.23.468420 — cancer biology — Posted on 2021-11-24
755 NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress
Raghavan, K. S.; Francescone, R.; Franco-Barraza, J.; Gardiner, J. C.; Vendramini-Costa, D. B.; Luong, T.; Pourmandi, N.; Kurimchak, A.; Ogier, C.; Duncan, J. S.; Lyssiotis, C. A.; Languino, L. R.; Cukierman, E.
10.1101/2021.11.21.469456 — cancer biology — Posted on 2021-11-24
756 Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure
Stelzl, L. S.; Pietrek, L. M.; Holla, A.; Oroz, J. S.; Sikora, M.; Köfinger, J.; Schuler, B.; Zweckstetter, M.; Hummer, G.
10.1101/2021.11.23.469691 — biophysics — Posted on 2021-11-24
757 Atomic resolution Protein Allostery from the multi-state Structure of a PDZ Domain
Ashkinadze, D.; Kadavath, H.; Chi, C. N.; Friedmann, M.; Strotz, D.; Kumari, P.; Minges, M.; Cadalbert, R.; KÖnigl, S.; Güntert, P.; Vogeli, B.; Riek, R.
10.1101/2021.11.23.469649 — biophysics — Posted on 2021-11-24
761 Genomic variation across a clinical Cryptococcus population linked to disease outcome
Sephton-Clark, P. C. S.; Tenor, J.; Toffaletti, D.; Meyers, N.; Giamberardino, C.; Molloy, S.; Chan, A.; Chikaonda, T.; Heyderman, R.; Hosseinipour, M.; Kalata, N.; Kanyama, C.; Kukacha, C.; Lupiya, D.; Mwandumba, H.; Harrison, T.; Bicanic, T.; Perfect, J. R.; Cuomo, C. A.
10.1101/2021.11.22.469645 — genomics — Posted on 2021-11-24
762 Genetic mapping of a bioethanol yeast strain reveals new targets for aldehyde- and thermotolerance
de Mello, F. d. S. B.; Coradini, A. L. V.; Carazzolle, M. F.; Maneira, C.; Furlan, M.; Pereira, G. G. A.; Teixeira, G. S.
10.1101/2021.11.23.469769 — genetics — Posted on 2021-11-24
765 Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
Amatngalim, G. D.; Rodenburg, L. W.; Aalbers, B. L.; Raeven, H. H. M.; Aarts, E. M.; Silva, I. A. L.; Nijenhuis, W.; Vrendenbarg, S.; Kruisselbrink, E.; Brunsveld, J.; van Drunen, C. M.; Michel, S.; de Winter-de Groot, K. M.; Heijerman, H. G.; Kapitein, L. C.; Amaral, M. D.; van der Ent, C. K.; Beekman, J. M.
10.1101/2021.07.20.453105 — cell biology — Posted on 2021-11-24
766 Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen
Mac Kain, A.; Maarifi, G.; Aicher, S.-M.; Arhel, N.; Baidaliuk, A.; Munier, S.; Donati, F.; Vallet, T.; Tran, Q. D.; Hardy, A.; Chazal, M.; Porrot, F.; Ohainle, M.; Carlson-Stevermer, J.; Oki, J.; Holden, K.; Simon-Loriere, E.; Bruel, T.; Schwartz, O.; van der Werf, S.; Jouvenet, N.; Nisole, S.; Vignuzzi, M.; Roesch, F.
10.1101/2021.05.06.442916 — microbiology — Posted on 2021-11-24
767 Tonic engagement of nicotinic receptors bidirectionally controls striatal spiny projection neuron spike timing
Matityahu, L.; Malgady, J.; Schirelman, M.; Johansson, Y.; Wilking, J.; Silberberg, G.; Goldberg, J. A.; Plotkin, J. L.
10.1101/2021.11.02.466870 — neuroscience — Posted on 2021-11-24
768 Astrocytic expression of ALS-causative mutant FUS leads to TNFa-dependent neurodegeneration in vivo
Jensen, B. K.; McAvoy, K. J.; Heinsinger, N. M.; Lepore, A. C.; Ilieva, H.; Haeusler, A.; Trotti, D.; Pasinelli, P.
10.1101/2021.11.23.469650 — neuroscience — Posted on 2021-11-24
770 Universal COVID-19 vaccine with updated spike antigen confers full protection against all SARS-CoV-2 variants of concern.
Sharma, S.; Vercruysse, T.; Sanchez-Felipe, L.; Kerstens, W.; Abdelnabi, R.; Foo, C. S.; Lemmens, V.; Van Looveren, D.; Maes, P.; Baele, G.; Weynand, B.; Lemey, P.; Neyts, J.; Thibaut, H. J.; Dallmeier, K.
10.1101/2021.11.12.468374 — microbiology — Posted on 2021-11-24
771 Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization
Singh, T.; Hwang, K.-K.; Miller, A. S.; Jones, R. L.; Lopez, C. A.; Giuberti, C.; Gladden, M. A.; Miller, I.; Webster, H. S.; Eudailey, J. A.; Luo, K.; Von Holle, T.; Edwards, R. J.; Valencia, S.; Burgomaster, K. E.; Zhang, S.; Mangold, J. F.; Tu, J. J.; Dennis, M.; Alam, S. M.; Premkumar, L.; Dietze, R.; Pierson, T. C.; Ooi, E. E.; Lazear, H. M.; Kuhn, R. J.; Permar, S. R.; Bonsignori, M.
10.1101/2021.11.23.469700 — immunology — Posted on 2021-11-24
773 A Novel Ex Vivo Peritoneal Model to Investigate Mechanisms of Peritoneal Metastasis in Gastric Adenocarcinoma
Ng, D.; Ali, A.; Lee, K.; Eymael, D.; Abe, K.; Luu, S.; Kazazian, K.; Brar, S.; Conner, J.; Magalhaes, M.; Swallow, C. J.
10.1101/2021.11.15.468687 — cancer biology — Posted on 2021-11-24
783 Loss of CEP162 function at the primary cilium delays ciliogenesis and causes retinal ciliopathy in humans
Nuzhat, N.; Van Schil, K.; Liakopoulos, S.; Bauwens, M.; Duenas Rey, A.; Käseberg, S.; Jäger, M.; Willer, J. R.; Winter, J.; Truong, H.; Gruartmoner, N.; Van Heetvelde, M.; Wolf, J.; Merget, R.; Grasshoff-Derr, S.; Van Dorpe, J.; Hoorens, A.; Stöhr, H.; Mansard, L.; Roux, A.-F.; Langmann, T.; Dannhausen, K.; Rosenkranz, D.; Wissing, K. M.; Van Lint, M.; Rossmann, H.; Häuser, F.; Nürnberg, P.; Thiele, H.; Zechner, U.; Pearring, J. N.; De Baere, E.; Bolz, H. J.
10.1101/2021.11.23.469779 — genetics — Posted on 2021-11-23
785 A standardized non-visual behavioral event is broadcasted homogeneously across cortical visual areas without modulating visual responses
Ramadan, M.; Lee, E. K.; de Vries, S.; Caldejon, S.; Kato, I.; Roll, K.; Griffin, F.; Nguyen, T.; Larkin, J.; Rhoads, P.; Mace, K.; Kriedberg, A.; Howard, R.; Berbesque, N.; Lecoq, J.
10.1101/2020.12.15.422967 — neuroscience — Posted on 2021-11-23
787 Transection injury differentially alters the proteome of the human sural nerve
Chau, M. J.; Quintero, J. E.; Blalock, E.; Samaan, C.; Gerhardt, G.; van Horne, C.
10.1101/2021.11.23.469670 — neuroscience — Posted on 2021-11-23
791 Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway
Edgar, R. C. S.; Siddiqui, G.; Hjerrild, K.; Malcolm, T. R.; Vinh, N. B.; Webb, C. T.; MacRaild, C. A.; Counihan, N. A.; Creek, D. J.; Scammels, P. J.; McGowan, S.; De Koning-Ward, T. F.
10.1101/2021.11.23.469631 — microbiology — Posted on 2021-11-23
792 Activation of peripheral neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain
Tassou, A.; Thouaye, M.; Gilarbert, D.; Jouvenel, A.; Leyris, J.-P.; Sonrier, C.; Diouloufet, L.; Mechaly, I.; Chentouf, M.; Neiveyans, M.; Pugniere, M.; Martineau, P.; Robert, B.; Capdevila, X.; Valmier, J.; Rivat, C.
10.1101/2021.11.23.469557 — neuroscience — Posted on 2021-11-23
793 Contractile force of transplanted cardiomyocytes contributes to heart function after injury
Stuedemann, T.; Roessinger, J.; Manthey, C.; Geertz, B.; Srikantharajah, R.; von Bibra, C. C.; Shibamiya, A.; Koehne, M.; Wiehler, A.; Wiegert, J. S.; Eschenhagen, T.; Weinberger, F.
10.1101/2021.11.23.469715 — pharmacology and toxicology — Posted on 2021-11-23
794 Fuzzy set intersection based paired-end short-read alignment
Bolosky, W. J.; Subramaniyan, A.; Zaharia, M.; Pandya, R.; Sittler, T.; Patterson, D.
10.1101/2021.11.23.469039 — bioinformatics — Posted on 2021-11-23
795 High-dimensional association detection in large scale genomic data
Koch, H.; Keller, C. A.; Xiang, G.; Giardine, B.; Zhang, F.; Wang, Y.; Hardison, R. C.; Li, Q.
10.1101/2020.11.18.388504 — bioinformatics — Posted on 2021-11-23
796 Conserved recombination patterns across coronavirus subgenera
de Klerk, A.; Swanepoel, P. I.; Lourens, R. F.; Zondo, M.; Abodunran, I.; Lytras, S.; MacLean, O.; Robertson, D. L.; Kosakovsky Pond, S. L.; Zehr, J. D.; Kumar, V.; Stanhope, M. J.; Harkins, G.; Murrell, B.; Martin, D.
10.1101/2021.11.21.469423 — bioinformatics — Posted on 2021-11-23
798 Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
Zhou, C.; Liu, Q.; Chang, C. E.; Wooldredge, A. C.; Fong, B.; Kennedy, B. K.
10.1101/2021.11.23.469672 — cell biology — Posted on 2021-11-23
799 Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein
Jiang, S.; Wu, S.; Zhao, G.; He, Y.; Guo, X.; Zhang, Z.; Hou, J.; Ding, Y.; Cheng, A.; Wang, B.
10.1101/2021.11.21.469172 — immunology — Posted on 2021-11-23
802 Comparison of neuromuscular junction dynamics following ischemic and aged skeletal muscle
Aliya, B.; Mohiuddin, M.; Choi, J.; Jeong, G.; Kang, I.; Castels, H.; Jones, C.; Jang, Y. C.
10.1101/2021.11.23.469760 — neuroscience — Posted on 2021-11-23
806 Molecular Basis of Antibiotic Self-Resistance in a Bee Larvae Pathogen
Dang, T.; Loll, B.; Müller, S.; Skobalj, R.; Ebeling, J.; Bulatov, T.; Gensel, S.; Göbel, J.; Wahl, M.; Genersch, E.; Mainz, A.; Süssmuth, R. D.
10.1101/2021.11.23.469742 — biochemistry — Posted on 2021-11-23
808 Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbations
Patel, T.; Carnwath, T. P.; Wang, X.; Allen, M.; Lincoln, S. J.; Lewis-Tuffin, L. J.; Quicksall, Z. S.; Lin, S.; Tutor-New, F. Q.; Ho, C. C.; Min, Y.; Malphrus, K. G.; Nguyen, T. T.; Martin, E.; Garcia, C. A.; Alkharboosh, R. M.; Grewal, S.; Chaichana, K.; Wharen, R.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Ertekin-Taner, N.
10.1101/2021.05.13.444000 — genetics — Posted on 2021-11-23
811 Circular RNA signatures of human healing and non-healing wounds
Toma, M. A.; Liu, Z.; Wang, Q.; Zhang, L.; Li, D.; Sommar, P.; Xu Landen, N.
10.1101/2021.11.23.469681 — cell biology — Posted on 2021-11-23
813 Directing iPSC Differentiation into iTenocytes using Combined Scleraxis Overexpression and Cyclic Loading
Papalamprou, A.; Yu, V.; Chen, A.; Stefanovic, T.; Kaneda, G.; Salehi, K.; Castaneda, C.; Gertych, A.; Glaeser, J. D.; Sheyn, D.
10.1101/2021.11.23.469329 — cell biology — Posted on 2021-11-23
818 Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome
Dean, D. A.; Klechka, L.; Hossain, E.; Parab, A. R.; Eaton, K.; Hinsdale, M.; McCall, L.-I.
10.1101/2021.11.22.469643 — microbiology — Posted on 2021-11-23
819 Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization
Singh, T.; Hwang, K.-K.; Miller, A. S.; Jones, R. L.; Lopez, C. A.; Giuberti, C.; Gladden, M. A.; Miller, I.; Webster, H. S.; Eudailey, J. A.; Luo, K.; Von Holle, T.; Edwards, R. J.; Valencia, S.; Burgomaster, K. E.; Zhang, S.; Mangold, J. F.; Tu, J. J.; Dennis, M.; Alam, S. M.; Premkumar, L.; Dietze, R.; Pierson, T. C.; Ooi, E. E.; Lazear, H. M.; Kuhn, R. J.; Permar, S. R.; Bonsignori, M.
10.1101/2021.11.23.469700 — immunology — Posted on 2021-11-23
822 In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain
Ruetz, T. J.; Kashiwagi, C. M.; Morton, B.; Yeo, R. W.; Leeman, D. S.; Morgens, D. W.; Tsui, C. K.; Li, A.; Bassik, M. C.; Brunet, A.
10.1101/2021.11.23.469762 — neuroscience — Posted on 2021-11-23
827 START domain mediates Arabidopsis GLABRA2 transcription factor dimerization and turnover independently of homeodomain DNA binding
Mukherjee, T.; Subedi, B.; Khosla, A.; Warner, A. L.; Lerma-Reyes, R.; Thompson, K. A.; Gunewardena, S.; Schrick, K.
10.1101/2021.11.23.469727 — plant biology — Posted on 2021-11-23
828 Lymphatic Thrombosis and Impaired Lymph Drainage in Cigarette Smoke-Associated Emphysema
Summers, B. D.; Kim, K.; Khan, Z.; Thangaswamy, S.; Clement, C. C.; McCright, J.; Maisel, K.; Zamora, S.; Quintero, S.; Racanelli, A. C.; Yang, J.; D'Armiento, J.; Monticelli, L. A.; Kahn, M. L.; Choi, A. M. K.; Santambrogio, L.; Reed, H. O.
10.1101/2021.11.23.469393 — pathology — Posted on 2021-11-23
829 Sarcoplasmic reticulum calcium handling in young DBA/2J vs C57BL/10 mdx models of Duchenne muscular dystrophy
Cleverdon, R. E.; Whitley, K. C.; Marko, D. M.; Hamstra, S. I.; Braun, J. L.; Roy, B. D.; MacPherson, R. E.; Fajardo, V.
10.1101/2021.10.25.465805 — pathology — Posted on 2021-11-23
831 HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, whereas cyclocreatine therapy impairs invasion and improves the efficacy of conventional chemotherapies
Krutilina, R. I.; Playa, H. C.; Brooks, D. L.; Schwab, L. P.; Parke, D. N.; Oluwalana, D.; Layman, D. R.; Fan, M.; Johnson, D. L.; Yue, J.; Smallwood, H.; Seagroves, T. N.
10.1101/2021.09.09.459646 — cancer biology — Posted on 2021-11-23
832 Ear pinnae in a neotropical katydid (Orthoptera: Tettigoniidae) function as ultrasound guides for bat detection
Pulver, C.; Celiker, E.; Woodrow, C.; Geipel, I.; Soulsbury, C.; Cullen, D.; Rogers, S. M.; Veitch, D.; Montealegre-Z, F.
10.1101/2021.09.01.458595 — biophysics — Posted on 2021-11-23
834 Single virus assay reveals membrane determinants and mechanistic features of Sendai virus binding
Lam, A.; Kirkland, O. O.; Anderson, P. F.; Seetharaman, N.; Vujovic, D.; Thibault, P. A.; Azarm, K. D.; Lee, B. A.; Rawle, R. J.
10.1101/2021.11.23.469711 — biophysics — Posted on 2021-11-23
835 Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease
Johnson, T. S.; Yu, C. Y.; Huang, Z.; Xu, S.; Wang, T.; Dong, C.; Shao, W.; Abu Zaid, M.; Huang, X.; Wang, Y.; Bartlett, C.; Zhang, Y.; Walker, B.; Liu, Y.; Zhang, J.; Huang, K.
10.1101/2020.06.16.142984 — bioinformatics — Posted on 2021-11-23
837 Virtual screening for small molecule pathway regulators by image profile matching
Rohban, M. H.; Fuller, A. M.; Tan, C.; Goldstein, J. T.; Syangtan, D.; Gutnick, A.; Nijsure, M. P.; Rigby, M.; Sacher, J. R.; Corsello, S. M.; Peppler, G. B.; Bogaczynska, M.; Boghossian, A.; Ciotti, G. E.; DeVine, A.; Doan, M.; Gale, J. P.; Derynck, R.; Turbyville, T.; Boerckel, J. D.; Singh, S.; Kiessling, L. L.; Schwarz, T. L.; Varelas, X.; Wagner, F. F.; Kafri, R.; Eisinger-Mathason, T. S. K.; Carpenter, A. E.
10.1101/2021.07.29.454377 — bioinformatics — Posted on 2021-11-23
839 Protonation-Dependent Sequencing of 5-Formylcytidine in RNA
Link, C. N.; Gamage, S. T.; Gallimore, D. A.; Kopajtich, R.; Evans, C. N.; Nance, S. R.; Fox, S. D.; Andresson, T.; Chari, R.; Ivanic, J.; Prokisch, H.; Meier, J. L.
10.1101/2021.11.23.469744 — biochemistry — Posted on 2021-11-23
840 An allelic series of spontaneous mutations in Rorb cause a gait phenotype, retinal abnormalities, and transcriptomic changes relevant to human neurodevelopmental conditions
Murray, G. C.; Bubier, J.; Zinder, O. J.; Harris, B.; Clark, J.; Christopher, M.-C.; Hanley, C.; Tjong, H.; Li, M.; Ngan, C. Y.; Reinholdt, L.; Burgess, R. W.; Tadenev, A. L.
10.1101/2021.11.23.468991 — genetics — Posted on 2021-11-23
841 Dosage sensitivity in Pumilio1-associated diseases involves two distinct mechanisms
Botta, S.; de Prisco, N.; Chemiakine, A.; Cabaj, M.; Patel, P.; Soni, R. K.; Gennarino, V. A.
10.1101/2021.03.11.435015 — genetics — Posted on 2021-11-23
844 Competition for endothelial cell polarity drives vascular morphogenesis
Barbacena, P.; Dominguez-Cejudo, M.; Fonseca, C. G.; Gomez-Gonzalez, M.; Faure, L. M.; Zarkada, G.; Pena, A. A.; Pezzarossa, A.; Ramalho, D.; Giarratano, Y.; Ouarne, M.; Barata, D.; Fortunato, I.; Misikova, L. H.; Mauldin, I.; Carvalho, Y.; Trepat, X.; Roca-Cusachs, P.; Eichmann, A.; Bernabeu, M. O.; Franco, C.
10.1101/2021.11.23.469704 — developmental biology — Posted on 2021-11-23
845 Vibrio cholerae El Tor strains linked to global cholera are homogeneous by pulsed-field gel electrophoresis
Johura, F.-T.; Biswas, S. R.; Rashed, S. M.; Islam, M. T.; Islam, S.; Sultana, M.; Huq, A.; Thomson, N. R.; Colwell, R. R.; Watanabe, H.; Alam, M.
10.1101/2021.11.22.469504 — molecular biology — Posted on 2021-11-23
846 HSFs drive stress type-specific transcription of genes and enhancers
Himanen, S. V.; Puustinen, M. C.; Da Silva, A. J.; Vihervaara, A.; Sistonen, L.
10.1101/2021.11.23.469701 — molecular biology — Posted on 2021-11-23
848 RNA-guided Cas12a and Cas9 knockout and knockin of the omega-1 locus of Schistosoma mansoni
Tanno, W. I.; Chatupheeraphat, C.; Mann, V. H.; Li, W.; Miller, A.; Ogunbayo, T.; Tran, K.; Alrefael, Y.; Mentink-Kane, M.; Brindley, P. J.
10.1101/2021.11.15.468743 — molecular biology — Posted on 2021-11-23
849 Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations
Damianou, A.; Liang, Z.; Kessler, B. M.; Lassen, F.; Vere, G.; Hester, S.; Charles, P.; Pinto-Fernandez, A.; Fisher, R.; Santos-Delgado, A.
10.1101/2021.11.23.469679 — molecular biology — Posted on 2021-11-23
850 Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain
Piel, L.; Rajan, K. S.; Bussotti, G.; Varet, H.; Legendre, R.; Proux, C.; Douche, T.; Giai Gianetto, Q.; Chaze, T.; Cokelaer, T.; Vojtkova, B.; Gordon-Bar, N.; Doniger, T.; Cohen-Chalamish, S.; Rengaraj, P.; Besse, C.; Boland, A.; Sadlova, J.; Deleuze, J.-F.; Matondo, M.; Unger, R.; Volf, P.; Michaeli, S.; Pescher, P.; Spaeth, G. F.
10.1101/2021.03.22.436378 — microbiology — Posted on 2021-11-23
851 Peptidoglycan recycling contributes to outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii
Islam, N.; Kazi, M. I.; Kang, K. N.; Biboy, J.; Gray, J.; Ahmed, F.; Schargel, R. D.; Boutte, C. C.; Doerr, T.; Vollmer, W.; Boll, J. M.
10.1101/2021.11.23.469614 — microbiology — Posted on 2021-11-23
852 Preclinical efficacy, safety, and immunogenicity of PHH-1V, a second-generation COVID-19 vaccine candidate based on a novel recombinant RBD fusion heterodimer of SARS-CoV-2.
Barreiro, A.; Prenafeta, A.; Bech-Sabat, G.; Roca, M.; March, R.; Gonzalez, L.; Madrenas, L.; Corominas, J.; Fernandez, A.; Molas, M.; Vergara-Alert, J.; Lorca-Oro, C.; Roca, N.; Fernandez-Bastit, L.; Rodon, J.; Perez, M.; Segales, J.; Pradenas, E.; Marfil, S.; Trinite, B.; Ortiz, R.; Clotet, B.; Blanco, J.; Diaz Pedroza, J.; Ampudia Carrasco, R.; Rosales Salgado, Y.; Loubat Casanovas, J.; Capdevila Larripa, S.; Garcia Prado, J.; Barretina Ginesta, J.; Sistere-Oro, M.; Cebollada Rica, P.; Meyerhans, A.; Ferrer, L.; Torroella, E.
10.1101/2021.11.22.469117 — immunology — Posted on 2021-11-23
854 KEEPING IN TOUCH WITH OUR HIDDEN SIDE
Mathieu, B.; Abillama, A.; Martinez, M.; Mouchnino, L.; Blouin, J.
10.1101/2021.11.23.469678 — neuroscience — Posted on 2021-11-23
858 Post-trauma behavioral phenotype predicts vulnerability to fear relapse after extinction
Demars, F.; Todorova, R.; Makdah, G.; Forestier, A.; Krebs, M.-O.; Godsil, B. P.; Jay, T. M.; Wiener, S. I.; Pompili, M. N.
10.1101/2021.09.25.461769 — neuroscience — Posted on 2021-11-23
862 Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools
Götz, M.; Barth, A.; Bohr, S. S.- R.; Börner, R.; Chen, J.; Cordes, T.; Erie, D. A.; Gebhardt, C.; Hadzic, M. C. A. S.; Hamilton, G. L.; Hatzakis, N. S.; Hugel, T.; Kisley, L.; Lamb, D. C.; de Lannoy, C.; Mahn, C.; Dunukara, D.; de Ridder, D.; Sanabria, H.; Schimpf, J.; Seidel, C. A. M.; Sigel, R. K. O.; Sletfjerding, M. B.; Thomsen, J.; Vollmar, L.; Wanninger, S.; Weninger, K. R.; Xu, P.; Schmid, S.
10.1101/2021.11.23.469671 — biophysics — Posted on 2021-11-23
867 TFAP2 paralogs pioneer chromatin access for MITF and directly inhibit genes associated with cell migration
Kenny, C.; Dilshat, R.; Seberg, H.; Van Otterloo, E.; Bonde, G.; Helverson, A.; Steingrimsson, E.; Cornell, R. A.
10.1101/2021.11.23.469757 — developmental biology — Posted on 2021-11-23
869 SmdA is a novel cell morphology determinant in Staphylococcus aureus
Myrbraten, I. S.; Stamsas, G. A.; Chan, H.; Morales Angeles, D.; Knutsen, T. M.; Salehian, Z.; Shapaval, V.; Straume, D.; Kjos, M.
10.1101/2021.11.23.469651 — microbiology — Posted on 2021-11-23
870 Categorical encoding of voice in human superior temporal cortex
Rupp, K.; Hect, J. L.; Remick, M.; Ghuman, A.; Chandresekaran, B.; Holt, L.; Abel, T. J.
10.1101/2021.11.23.469682 — neuroscience — Posted on 2021-11-23
871 Cryo-EM structure of the octameric pore of Clostridium perfringens β-toxin
Bruggisser, J.; Iacovache, I.; Musson, S. C.; Degiacomi, M. T.; Posthaus, H.; Zuber, B.
10.1101/2021.11.23.469684 — biophysics — Posted on 2021-11-23
872 Genomic variation in the tea leafhopper reveals the basis of adaptive evolution
Zhao, Q.; Shi, L.; He, W.; Li, J.; You, S.; Chen, S.; Lin, J.; Wang, Y.; Zhang, L.; Yang, G.; Vasseur, L.; You, M.
10.1101/2021.11.23.469662 — genomics — Posted on 2021-11-23
873 A metagenomic DNA sequencing assay that is robust against environmental DNA contamination
Mzava, O.; Cheng, A. P.; Chang, A.; Smalling, S.; Kounatse, L.-A. D.; Lenz, J. S.; Longman, R.; Steadman, A.; Mason, C.; Salvatore, M.; Suthan, M.; Lee, J. R.; Dadhania, D.; De Vlaminck, I.
10.1101/2021.11.22.469599 — genomics — Posted on 2021-11-23
874 Genomic regions associated with chocolate spot (Botrytis fabae Sard.) resistance in fababean (Vicia faba L.)
Gela, T. S.; Bruce, M.; Chang, W.; Stoddard, F. L.; Schulman, A. H.; Vandenberg, A.; Khazaei, H.
10.1101/2021.11.22.469473 — genomics — Posted on 2021-11-23
877 Parent-offspring inference in highly inbred populations
Runge, J.-N.; König, B.; Lindholm, A. K.; Bendesky, A.
10.1101/2021.11.23.469656 — genetics — Posted on 2021-11-23
880 Firefly bioluminescence outshines aerial predators
Powell, G. S.; Saxton, N. A.; Pacheco, Y.; Stanger-Hall, K. F.; Martin, G. J.; Kusy, D.; Bocak, L.; Branham, M. A.; Bybee, S. M.
10.1101/2021.11.22.469605 — evolutionary biology — Posted on 2021-11-23
883 Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila
Logeay, R.; Geminard, C.; Lassus, P.; Rodriguez-Vazquez, M.; Kantar, D.; Heron-Milhavet, L.; Fischer, B.; Bray, S. J.; Colinge, J.; Djiane, A.
10.1101/2020.02.07.938621 — developmental biology — Posted on 2021-11-23
888 Evasion of Toll-like Receptor Recognition by Escherichia coli is mediated via Population Level Regulation of Flagellin Production
Lanz, M.; Birchall, C. M.; Drage, L. K.; Picton, D. M.; Mowbray, C.; Alsenani, Q.; Tan, A. M. Z.; Ali, A.; Harding, C.; Pickard, R.; Hall, J.; Aldridge, P. D.
10.1101/2021.11.18.469103 — microbiology — Posted on 2021-11-23
890 Discovering Novel Antimicrobial Peptides in Generative Adversarial Network
Lin, T.-T.; Yang, L.-Y.; Wang, C.-T.; Lai, G.-W.; Ko, C.-F.; Shih, Y.-H.; Chen, S.-H.; Lin, C.-Y.
10.1101/2021.11.22.469634 — microbiology — Posted on 2021-11-23
891 Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome
Dean, D. A.; Klechka, L.; Hossain, E.; Parab, A. R.; Eaton, K.; Hinsdale, M.; McCall, L.-I.
10.1101/2021.11.22.469643 — microbiology — Posted on 2021-11-23
896 Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control
Gideon, H. P.; Hughes, T. K.; Tzouanas, C. N.; Wadsworth, M. H.; Tu, A. A.; Gierahn, T. M.; Peters, J. M.; Hopkins, F. H.; Wei, J.-R.; Kummerlowe, C.; Grant, N. L.; Nargan, K.; Phuah, J.; Borish, H. J.; Maiello, P.; White, A. G.; Winchell, C. G. M.; Nyquist, S. K.; Ganchua, S. K. C.; Myers, A.; Patel, K.; Ameel, C.; Cochran, C. T.; Ibrahim, S.; Tomko, J. A.; Frye, L. J.; Rosenberg, J.; Shih, A.; Chao, M.; Scanga, C.; Ordovas-Montanes, J.; Berger, B.; Mattila, J. T.; Madansein, R.; Love, J. C.; Lin, P. L.; Leslie, A.; Behar, S. M.; Bryson, B. D.; Flynn, J. L.; Fortune, S. M.; Shalek, A. K.
10.1101/2020.10.24.352492 — immunology — Posted on 2021-11-23
897 Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging
Sonar, S. A.; Uhrlaub, J. L.; Coplen, C. P.; Sempowski, G. D.; Dudakov, J. A.; van den Brink, M. R. M.; LaFleur, B. J.; Jergovic, M.; Nikolich-Zugich, J.
10.1101/2021.11.22.469479 — immunology — Posted on 2021-11-23
899 Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication
Vanderwall, E. R.; Barrow, K. A.; Rich, L. M.; Read, D. F.; Trapnell, C.; Oghenemega, O.; Ziegler, S. F.; Hallstrand, T. S.; White, M. P.; Debley, J. S.
10.1101/2021.11.20.469409 — immunology — Posted on 2021-11-23
900 Cholinergic control of striatal GABAergic microcircuits
Kocaturk, S.; Shah, F.; Guven, E. B.; Tepper, J. M.; Assous, M.
10.1101/2021.11.22.469580 — neuroscience — Posted on 2021-11-23
901 Increased heterogeneity and task-related reconfiguration of functional connectivity within a lexicosemantic network in autism
Sridhar, A.; Jao Keehn, R. J.; Wilkinson, M. K.; Gao, Y.; Olson, M.; Mash, L. E.; Alemu, K.; Manley, A.; Marinkovic, K.; Linke, A. C.; Mueller, R.-A.
10.1101/2021.11.22.469604 — neuroscience — Posted on 2021-11-23
902 Visual Attention in The Fovea and The Periphery during Visual Search
Zhang, J.; Zhu, X.; Wang, S.; Esteky, H.; Tian, Y.; Desimone, R.; Zhou, H.
10.1101/2021.11.22.469359 — neuroscience — Posted on 2021-11-23
903 Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array
Sombeck, J.; Heye, J.; Kumaravelu, K.; Goetz, S. M.; Peterchev, A. V.; Grill, W. M.; Bensmaia, S. J.; Miller, L. E.
10.1101/2021.11.22.469555 — neuroscience — Posted on 2021-11-23
904 Rapid reconstruction of neural circuits using tissue expansion and lattice light sheet microscopy
Lillvis, J. L.; Otsuna, H.; Ding, X.; Pisarev, I.; Kawase, T.; Colonell, J.; Rokicki, K.; Goina, C.; Gao, R.; Hu, A.; Wang, K.; Bogovic, J.; Milkie, D. E.; Meienberg, L.; Boyden, E. S.; Saalfeld, S.; Tillberg, P.; Dickson, B. J.
10.1101/2021.11.14.468535 — neuroscience — Posted on 2021-11-23
908 Patient brain organoids identify a link between the 16p11.2 copy number variant and the RBFOX1 gene.
Kostic, M.; Raymond, J. J.; Henry, B.; Tumkaya, T.; Khlghatyan, J.; Dvornik, J.; Hsiao, J.; Cheon, S. H.; Chung, J.; Sun, Y.; Dolmetsch, R.; Worringer, K. A.; Ihry, R.
10.1101/2021.11.21.469432 — neuroscience — Posted on 2021-11-23
909 A critical period of translational control during brain development at codon resolution
Harnett, D.; Ambrozkiewicz, M. C.; Zinnall, U.; Rusanova, A.; Borisova, E.; Dannenberg, R.; Imami, K.; Muenster-Wandowski, A.; Fauler, B.; Mielke, T.; Selbach, M.; Landthaler, M.; Spahn, C. M. T.; Tarabykin, V.; Ohler, U.; Kraushar, M. L.
10.1101/2021.06.23.449626 — neuroscience — Posted on 2021-11-23
912 Viral genome-capsid core senses host environments to prime RNA release
Ramesh, R.; Braet, S. M.; Venkatakrishnan, V.; Raghuvamsi, P. V.; Bao, J. C. W.; Marzinek, J. K.; Wu, C.; Gao, R.; Wong, S.-M.; Bond, P. J.; Anand, G.
10.1101/2021.11.23.469659 — plant biology — Posted on 2021-11-23
913 LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001
Martin Vazquez, E.; Cobo_Vuilleumier, N.; Araujo Legido, R.; Nola, E.; Lopez Bermudo, L.; Crespo, A.; Romero-Zerbo, S. Y.; Garcia-Fernandez, M.; Martin Montalvo, A.; Rojas, A.; Comaills, V.; Bermudez-Silva, F. J.; Gannon, M.; Martin, F.; Lorenzo, P. I.; Gauthier, B. R.
10.1101/2021.11.02.466895 — physiology — Posted on 2021-11-23
914 Single-cell dissection of obesity-exercise axis in adipose-muscle tissues
Yang, J.; Vamvini, M.; Nigro, P.; Ho, L.-L.; Galani, K.; Alvarez, M.; Tanigawa, Y.; Laakso, M.; Agudelo, L.; Pajukanta, P.; Middelbeek, R.; Grove, K.; Goodyear, L.; Kellis, M.
10.1101/2021.11.22.469622 — physiology — Posted on 2021-11-23
916 A non-canonical convergence of carbohydrate and glutamine metabolism is required after metabolic rewiring in a solid environment
Wei, P.; Bott, A. J.; Cluntun, A. A.; Morgan, J. T.; Cunningham, C. N.; Schell, J. C.; Ouyang, Y.; Ficarro, S. B.; Marto, J. A.; Danial, N. N.; DeBerardinis, R. J.; Rutter, J.
10.1101/2021.08.26.457847 — cancer biology — Posted on 2021-11-23
917 FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer
Guneri Sozeri, P. Y.; Ozden Yilmaz, G.; Kisim, A.; Eray, A.; Uzuner, H.; Karakulah, G.; Pesen Okvur, D.; Senturk, S.; Erkek Ozhan, S.
10.1101/2021.11.22.468946 — cancer biology — Posted on 2021-11-23
922 The systematic assessment of completeness of public metadata accompanying omics studies
Huang, Y.-N.; Rajesh, A.; Ayyala, R.; Sarkar, A.; Guo, R.; Ling, E.; Nakashidze, I.; Wong, M. Y.; Hu, J.; Nosov, A.; Chang, Y.; Abedalthagafi, M. S.; Mangul, S.
10.1101/2021.11.22.469640 — bioinformatics — Posted on 2021-11-23
924 NLIMED: Natural Language Interface for ModelEntity Discovery in Biosimulation ModelRepositories
Munarko, Y.; Sarwar, D. M.; Atalag, K.; Gennari, J. H.; Neal, M. L.; Nickerson, D. P.
10.1101/756304 — bioinformatics — Posted on 2021-11-23
928 Jointly Optimized Spatial Histogram UNET Architecture (JOSHUA) for Adipose Tissue Segmentation
Peeples, J. K.; Jameson, J. F.; Kotta, N. M.; Grasman, J. M.; Stoppel, W. L.; Zare, A.
10.1101/2021.11.22.469463 — bioengineering — Posted on 2021-11-23
931 Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics
Jagadeesh, K. A.; Dey, K. K.; Montoro, D. T.; Mohan, R.; Gazal, S.; Engreitz, J. M.; Xavier, R. J.; Price, A. L.; Regev, A.
10.1101/2021.03.19.436212 — genomics — Posted on 2021-11-23
932 Opposing roles of Granzymes A and B in the immune response to intestinal infection
Vandereyken, M.; Chawla, A. S.; Arias, M.; Santiago, L.; Wenner, N.; Thomson, S.; Dikovskaya, D.; Nguyen, C.; Garzon-Tituana, M.; Hinton, J. C. D.; Pardo, J.; Swamy, M.
10.1101/2021.11.07.467595 — immunology — Posted on 2021-11-23
935 Intracranial human recordings reveal intensity coding for the pain of others in the insula
Soyman, E.; Bruls, R.; Ioumpa, K.; Müller-Pinzler, L.; Gallo, S.; van Straaten, E. C. W.; Self, M. W.; Peters, J. C.; Possel, J. K.; Onuki, Y.; Baayen, J. C.; Idema, S.; Keysers, C.; Gazzola, V.
10.1101/2021.06.23.449371 — neuroscience — Posted on 2021-11-23
943 Effect of therapeutic ultrasound on the mechanical and biological properties of fibroblasts
CARDENAS, R. P.; Pastrana-Rendon, H. F.; Avila-Bernal, A. G.; Ramirez-Martinez, A. M.; Navarrete-Jimenez, M. L.; Ondo-Mendez, A. O.; Garzon-Alvarado, D. A.
10.1101/2021.11.22.469508 — bioengineering — Posted on 2021-11-22
945 Copy number alterations and epithelial-mesenchymal transition genes in diffuse and intestinal gastric cancers in Mexican patients
Larios-Serrato, V.; Martinez-Ezquerro, J. D.; Valdez-Salazar, H.-A.; Torres, J.; Camorlinga-Ponce, M.; Pina-Sanchez, P.; Ruiz-Tachiquin, M.-E.
10.1101/2021.11.22.469612 — cancer biology — Posted on 2021-11-22
950 Bacterial but not fungal rhizosphere communities differ among perennial grass ecotypes under abiotic environmental stress
Sarkar, S.; Kamke, A.; Ward, K.; Ran, Q.; Feehan, B.; Thapa, S.; Anderson, L.; Galliart, M.; Jumpponen, A.; Johnson, L.; Lee, S. T. M.
10.1101/2021.11.15.468685 — bioinformatics — Posted on 2021-11-22
951 Extensive gene duplication in Arabidopsis revealed by pseudo-heterozygosity
Jaegle, B.; Soto-Jimenez, L. M.; Burns, R.; Rabanal, F. A.; Nordborg, M.
10.1101/2021.11.15.468652 — genomics — Posted on 2021-11-22
952 Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells
Bhattacharya, S.; Myers, J.; Baker, C.; Guo, M.; Danopoulos, S.; Myers, J.; Bandopadhyay, G.; Romas, S.; Huyck, H. L.; Misra, R. S.; Dutra, J.; Holden-Wiltse, J.; McDavid, A.; Ashton, J.; Al Alam, D.; Potter, S.; Whitsett, J. A.; Xu, Y.; Pryhuber, G. S.; Mariani, T. J.
10.1101/2020.06.16.156042 — genomics — Posted on 2021-11-22
956 Mechanically induced nuclear shuttling of β-catenin requires co-transfer of actin
Sen, B.; Xie, Z.; Howard, S.; Styner, M.; van Wijnen, A. j.; Uzer, G.; Rubin, J.
10.1101/2021.11.22.469581 — cell biology — Posted on 2021-11-22
958 The energy requirements of ion homeostasis determine the lifespan of starving bacteria
Schink, S. J.; Polk, M.; Athaide, E.; Mukherjee, A.; Ammar, C.; Liu, X.; Oh, S.; Chang, Y.-F.; Basan, M.
10.1101/2021.11.22.469587 — microbiology — Posted on 2021-11-22
962 The Unique Cytoarchitecture and Wiring of the Human Default Mode Network
Paquola, C.; Garber, M.; Frässle, S.; Royer, J.; Tavakol, S.; Cruces, R.; Jefferies, E.; Smallwood, J.; Bernhardt, B.
10.1101/2021.11.22.469533 — neuroscience — Posted on 2021-11-22
965 The gendered self: Evidence for differences in whole-brain dynamics
Uribe, C.; Escrichs, A.; De Filippi, E.; Sanz Perl, Y.; Junque, C.; Gomez-Gil, E.; Kringelbach, M. L.; Guillamon, A.; Deco, G.
10.1101/2021.11.19.469282 — neuroscience — Posted on 2021-11-22
968 Pancreatic α and β cells are globally phase-locked
Ren, H.; Li, Y.; Han, C.; Yu, Y.; Shi, B.; Peng, X.; Wu, S.; Yang, X.; sneppen, k.; Chen, L.; Tang, C.
10.1101/2020.08.16.252304 — systems biology — Posted on 2021-11-22
970 Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease
Saponara, E.; Penno, C.; Matadamas Guzman, M. L.; Brun, V.; Fischer, B.; Brousseau, M.; Wang, Z.-Y.; ODonnell, P.; Turner, J.; Graff Meyer, A.; Bollepalli, L.; dArio, G.; Roma, G.; Carbone, W.; Orsini, V.; Annunziato, S.; Obrecht, M.; Beckmann, N.; Saravanan, C.; Osmont, A.; Tropberger, P.; Richards, S.; Genoud, C.; Aebi, A.; Ley, S.; Ksiazek, I.; Nigsch, F.; Terraciano, L.; Bouwmeester, T.; Tchorz, J.; Ruffner, H.
10.1101/2021.11.22.469602 — physiology — Posted on 2021-11-22
972 In Diverse Conditions Intrinsic Chromatin Condensates Have Liquid-like Material Properties
Gibson, B. A.; Blaukopf, C.; Lou, T.; Doolittle, L. K.; Finkelstein, I. J.; Narlikar, G.; Gerlich, D. W.; Rosen, M. K.
10.1101/2021.11.22.469620 — biophysics — Posted on 2021-11-22
979 Genome Assembly and Population Resequencing Reveal the Geographical Divergence of 'Shanmei'(Rubus corchorifolius)
Yang, Y.; Zhang, K.; Xiao, Y.; Zhang, L.; Huang, Y.; Li, X.; Chen, S.; Peng, Y.; Yang, S.-H.; Liu, Y.; Cheng, F.
10.1101/2021.11.22.469527 — genomics — Posted on 2021-11-22
980 Ploidy variation and its implications for reproduction and population dynamics in two sympatric Hawaiian coral species
Stephens, T. G.; Strand, E. L.; Mohamed, A. R.; Williams, A.; Chiles, E. N.; Su, X.; Bhattacharya, D.; Putnam, H. M.
10.1101/2021.11.21.469467 — genomics — Posted on 2021-11-22
983 Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium
Engel, A. L.; Wang, Y.; Khuu, T.; Worrall, E.; Manson, M. A.; Lim, R. R.; Knight, K.; Yanagida, A.; Qi, J. H.; Ramakrishnan, A.; Weleber, R. G.; Klein, M.; Wilson, D. J.; Anand-Apte, B.; Hurley, J. B.; Du, J. L.; Chao, J. R.
10.1101/2021.01.06.425613 — cell biology — Posted on 2021-11-22
984 Single organoid RNA-sequencing reveals high organoid-to-organoid variability
Gehling, K.; Parekh, S.; Schneider, F.; Kirchner, M.; Kondylis, V.; Nikopoulou, C.; Tessarz, P.
10.1101/2021.11.22.469588 — cell biology — Posted on 2021-11-22
986 Long-term precision editing of neural circuits in mammals using engineered gap junction hemichannels
Ransey, E.; Chesnov, K.; Thomas, G.; Wisdom, E.; Bowman, R.; Rodriguez, T.; Adamson, E.; Almoril-Porras, A.; Walder-Christensen, K. K.; Hughes, D. N.; Schwennesen, H.; Mague, S. D.; Colon-Ramos, D.; Hultman, R.; Bursac, N.; Dzirasa, K.
10.1101/2021.08.24.457429 — neuroscience — Posted on 2021-11-22
988 Awake ripples enhance emotional memory encoding in the human brain
Zhang, H.; Skelin, I.; Ma, S.; Paff, M.; Yassa, M. A.; Knight, R. T.; Lin, J. J.
10.1101/2021.11.17.469047 — neuroscience — Posted on 2021-11-22
992 Thermodynamic Constraints on Electromicrobial Protein Production
Wise, L.; Marecos, S.; Randolph, K.; Nshimyumukiza, E.; Hassan, M.; Strouse, J.; Salimijazi, F.; Barstow, B.
10.1101/2021.11.22.469619 — synthetic biology — Posted on 2021-11-22
993 Upregulation of C4 characteristics does not consistently improve photosynthetic performance in intraspecific hybrids of a grass
Bianconi, M. E.; Sotelo, G.; Curran, E. V.; Milenkovic, V.; Samaritani, E.; Dunning, L. T.; Bertolino, L. T.; Osborne, C. P.; Christin, P.-A.
10.1101/2021.08.10.455822 — plant biology — Posted on 2021-11-22
994 Acute SARS-CoV-2 infection in pregnancy is associated with placental ACE-2 shedding
Taglauer, E. S.; Wachman, E. M.; Juttukonda, L.; Klouda, T.; Kim, J.; Wang, Q.; Ishiyama, A.; Hackam, D. J.; Yuan, K.; Jia, H.
10.1101/2021.11.19.469335 — pathology — Posted on 2021-11-22
997 Binding partners regulate unfolding of myosin VI to activate the molecular motor
dos Santos, A.; Fili, N.; Hari-Gupta, Y.; Gough, R. E.; Wang, L.; Martin-Fernandez, M. L.; Arron, J.; Wait, E.; Chew, T. L.; Toseland, C. P.
10.1101/2020.05.10.079236 — biophysics — Posted on 2021-11-22
1000 Quantification of vascular networks in photoacoustic mesoscopy
Brown, E. L.; Lefebvre, T. L.; Sweeney, P. W.; Stolz, B.; Gröhl, J.; Hacker, L.; Huang, Z.; Harrington, H.; Byrne, H.; Bohndiek, S. E.
10.1101/2021.11.22.469541 — bioengineering — Posted on 2021-11-22
1001 Powering electronic implants by high frequency volume conduction: in human validation
Minguillon, J.; Tudela-Pi, M.; Becerra-Fajardo, L.; Perera-Bel, E.; del-Ama, A. J.; Gil-Agudo, A.; Megia-Garcia, A.; Garcia-Moreno, A.; Ivorra, A.
10.1101/2021.03.15.435404 — bioengineering — Posted on 2021-11-22
1002 Long distance migration is a major factor driving local adaptation at continental scale in Coho Salmon
Rougemont, Q.; Xuereb, A.; Dallaire, X.; Moore, J.-S.; Normandeau, E.; Rondeau, E. B.; Withler, R.; Van Doornik, D.; Crane, P.; Naish, K.; Garza, J.-C.; Beacham, T.; Koop, B. F.; Bernatchez, L.
10.1101/2021.11.22.469546 — evolutionary biology — Posted on 2021-11-22
1003 A Field-Deployable Diagnostic Assay for the Visual Detection of Misfolded Prions
Christenson, P. R.; Li, M.; Rowden, G.; Schwabenlander, M.; Wolf, T. M.; Oh, S.-H.; Larsen, P. A.
10.1101/2021.11.22.469560 — molecular biology — Posted on 2021-11-22
1005 All-optical electrophysiology with improved genetically encoded voltage indicators reveals interneuron network dynamics in vivo
Tian, H.; Davis, H. C.; Wong-Campos, J. D.; Fan, L. Z.; Gmeiner, B.; Begum, S.; Werley, C. A.; Borja, G. B.; Upadhyay, H.; Shah, H.; Jacques, J.; Park, P.; Qi, Y.; Parot, V.; Deisseroth, K.; Cohen, A. E.
10.1101/2021.11.22.469481 — neuroscience — Posted on 2021-11-22
1015 Inhibition of the TLR4 signalling pathway with TAK-242 reduces RSV infection and cytokine release in primary airway epithelial cells
Broadbent, L.; Roberts, G. C.; Coey, J. D.; Barabas, J.; Shields, M. D.; Power, U. F.; the Breathing Together Consortium,
10.1101/2021.11.22.469503 — microbiology — Posted on 2021-11-22
1016 Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity
Rushdi, M. N.; Pan, V.; Li, K.; Travaglino, S.; Choi, H.-K.; Hong, J.; Griffitts, F.; Agnihotri, P.; Mariuzza, R. A.; Ke, Y.; Zhu, C.
10.1101/2021.11.22.469547 — immunology — Posted on 2021-11-22
1017 Characterization of SARS-CoV-2 public CD4+ αβ T cell clonotypes through reverse epitope discovery
Rosati, E.; Pogorelyy, M. V.; Minervina, A. A.; Franke, A.; Scheffold, A.; Bacher, P.; Thomas, P.
10.1101/2021.11.19.469229 — immunology — Posted on 2021-11-22
1018 Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity
Si, L.; Bai, H.; Oh, C. Y.; Zhang, T.; Jiang, A.; Hong, F.; Ye, Y.; Jordan, T. X.; Logue, J.; McGrath, M.; Belgur, C.; Nurani, A.; Cao, W.; Powers, R. K.; Prantil-Baun, R.; Gygi, S. P.; Frieman, M.; tenOever, B. R.; Ingber, D. E.
10.1101/2021.11.19.469183 — immunology — Posted on 2021-11-22
1019 Comparative transcriptional analysis of the satellite glial cell injury response
Jager, S. E.; Pallesen, L. T.; Lin, L.; Izzi, F.; Pinheiro, A. M.; Villa-Hernandez, S.; Cesare, P.; Vaegter, C. B.; Denk, F.
10.1101/2021.11.22.469443 — neuroscience — Posted on 2021-11-22
1024 Ions and lipids drive aggregation of surface-functionalized gold nanoparticles on lipid membranes
Lavagna, E.; Bochicchio, D.; De Marco, A. L.; Guven, Z. P.; Stellacci, F.; Rossi, G.
10.1101/2021.11.22.468803 — biophysics — Posted on 2021-11-22
1027 SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design
Srinivasan, V.; Brognaro, H.; Prabhu, P. R.; de Souza, E. E.; Guenther, S.; Reinke, P. Y. A.; J. Lane, T.; Ginn, H.; Han, H.; Ewert, W.; Sprenger, J.; Koua, F. H. M.; Falke, S.; Werner, N.; Andaleeb, H.; Ullah, N.; Alves Franca, B.; Wang, M.; Luana C Barra, A.; Perbandt, M.; Schwinzer, M.; Schmidt, C.; Brings, L.; Lorenzen, K.; Schubert, R.; Rahal Guaragna Machado, R.; Donizette Candido, E.; Bruna Leal Oliveira, D.; Luiz Durigon, E.; Yefanov, O.; Lieske, J.; Gelisio, L.; Domaracky, M.; Middendorf, P.; Groessler, M.; Trost, F.; Galchenkova, M.; Saouane, S.; Hakanpaeae, J.; Wolf, M.; Turk, D.; P
10.1101/2021.11.17.468943 — biochemistry — Posted on 2021-11-22
1031 ACE2 expression and localization are regulated by CFTR: implications beyond cystic fibrosis
Bezzerri, V.; Gentili, V.; Api, M.; Finotti, A.; Papi, C.; Tamanini, A.; Olioso, D.; Duca, M.; Tedesco, E.; Leo, S.; Borgatti, M.; Volpi, S.; Pinton, P.; Cabrini, G.; Gambari, R.; Blasi, F.; Lippi, G.; Rimessi, A.; Rizzo, R.; cipolli, m.
10.1101/2021.11.19.469220 — cell biology — Posted on 2021-11-22
1033 Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling
Muhammad Irfanur, R.; Ito, T.; Shimojo, D.; Arimoto, K.; Onodera, K.; Okada, R.; Nagashima, T.; Yamamoto, K.; Khatun, Z.; Okano, H.; Sakurai, H.; Shimizu, K.; Doyu, M.; Okada, Y.
10.1101/2021.11.22.468571 — cell biology — Posted on 2021-11-22
1039 Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy
Naulaerts, S.; Borras, D. M.; Martinez, A. A.; Messiaen, J.; Van Herck, Y.; Gelens, L.; Venken, T.; Vanmeerbeek, I.; More, S.; Sprooten, J.; Bechter, O.; Bergers, G.; Liston, A.; De Vleeschouwer, S.; Van den Eynde, B. J.; Lambrechts, D.; Borst, J.; Bosisio, F. M.; Tejpar, S.; De Smet, F.; Garg, A. D.
10.1101/2021.11.22.468617 — immunology — Posted on 2021-11-22
1041 Do naps benefit novel word learning? Developmental differences and white matter correlates
van Rijn, E.; Gouws, A.; Walker, S.; knowland, v.; Cairney, S.; Gaskell, M. G.; Henderson, L.
10.1101/2021.11.22.469237 — neuroscience — Posted on 2021-11-22
1042 Estradiol and oxytocin modulate sex differences in hippocampal reactivity and episodic memory
Coenjaerts, M.; Trimborn, I.; Adrovic, B.; Stoffel-Wagner, B.; Cahill, L.; Philipsen, A.; Hurlemann, R.; Scheele, D.
10.1101/2021.11.22.469500 — neuroscience — Posted on 2021-11-22
1044 Systematic assessment of the accuracy of subunit counting in biomolecular complexes using automated single molecule brightness analysis
Danial, J. S. H.; Quintana, Y.; Ros, U.; Shalaby, R.; Margheritis, E. G.; Chumpen, S.; Ungermann, C.; Garcia-Saez, A. J.; Cosentino, K.
10.1101/2021.11.22.469513 — biophysics — Posted on 2021-11-22
1046 Clonal hematopoiesis in individuals with ANKRD26 or ETV6 germline mutations
Drazer, M. W.; Homan, C. C.; Yu, K.; de Andrade Silva, M. C.; McNeely, K. E.; Pozsgai, M. J.; Acevedo, M. G.; Segal, J. P.; Wang, P.; Feng, J.; King-Smith, S. L.; Kim, E.; Korotev, S.; Lawrence, D. M.; Schreiber, A. W.; Hahn, C. N.; Scott, H. S.; Sood, R.; NISC Comparative Sequencing Program, ; Velloso, E. D. R. P.; Brown, A. L.; Liu, P. P.; Godley, L. A.
10.1101/2021.11.17.468983 — genetics — Posted on 2021-11-22
1047 Miniscope-LFOV: A large field of view, single cell resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals
Guo, C.; Blair, G. J.; Sehgal, M.; Sangiuliano Jimka, F. N.; Bellafard, A.; Silva, A. J.; Golshani, P.; Basso, M. A.; Blair, H. T.; Aharoni, D.
10.1101/2021.11.21.469394 — neuroscience — Posted on 2021-11-22
1052 A structured scaffold underlies activity in the hippocampus
Mulders, D.; Yim, M. Y.; Lee, J. S.; Lee, A. K.; Taillefumier, T.; Fiete, I.
10.1101/2021.11.20.469406 — neuroscience — Posted on 2021-11-22
1054 Antitumor Effects Of Phytochemicals Of Hot Three Plants On Gastric Adenocarcinoma
Ragchaasuren, N.; Tumurkhuu, M.; Byambaa, T.; Bold, U.; Dagvadorj, E.; Gendaram, O.; Dalkh, T.
10.1101/2021.11.21.469373 — cancer biology — Posted on 2021-11-22
1055 Ploidy variation and its implications for reproduction and population dynamics in two sympatric Hawaiian coral species
Stephens, T. G.; Strand, E. L.; Mohamed, A. R.; Williams, A.; Chiles, E. N.; Su, X.; Bhattacharya, D.; Putnam, H. M.
10.1101/2021.11.21.469467 — genomics — Posted on 2021-11-22
1056 Inferring the Demographic History of Japanese Eel (Anguilla japonica) from Genomic Data: Insights for Conservation and Fisheries Management
Faulks, L.; Kaushik, P.; Taniguchi, S.; Sekino, M.; Nakamichi, R.; Yamamoto, Y.; Fujimori, H.; Okamoto, C.; Kodama, S.; Daryani, A.; Manwong, A. F.; Galang, I.; Mochioka, N.; Araki, K.; Suzuki, M.; Kaji, Y.; Ichiki, T.; Matsunaga, T.; Hakoyama, H.
10.1101/2021.11.18.468312 — evolutionary biology — Posted on 2021-11-22
1058 The different brain areas occupied for integrating information of hierarchical linguistic units: a study based on EEG and TMS
Pei, C.; Qiu, Y.; Li, F.; Huang, X.; Si, Y.; Li, Y.; Zhang, X.; Chen, C.; Liu, Q.; Cao, Z.; Ding, N.; Gao, S.; Alho, K.; Yao, D.; Xu, P.
10.1101/2021.11.22.469495 — neuroscience — Posted on 2021-11-22
1061 Lasting effects of low-calorie sweeteners on glucose regulation, sugar intake, and memory
Tsan, L.; Chometton, S.; Zuo, Y.; Sun, S.; Hayes, A. M. R.; Bridi, L.; Lan, R.; Fodor, A. A.; Noble, E. E.; Yang, X.; Kanoski, S. E.; Schier, L. A.
10.1101/2021.11.22.469487 — neuroscience — Posted on 2021-11-22
1064 reComBat: Batch effect removal in large-scale, multi-source omics data integration
Adamer, M. F.; Brueningk, S. C.; Tejada-Arranz, A.; Estermann, F.; Basler, M.; Borgwardt, K. M.
10.1101/2021.11.22.469488 — bioinformatics — Posted on 2021-11-22
1065 CAMO: A molecular congruence analysis framework for evaluating model organisms
Zong, W.; Rahman, M. T.; Zhu, L.; Zeng, X.; Zhang, Y.; Zou, J.; Liu, S.; Ren, Z.; Li, J. J.; Oesterreich, S.; Ma, T.; Tseng, G.
10.1101/2021.11.21.469371 — genomics — Posted on 2021-11-22
1066 Reduction in population size and not a shift in parasite community affect evolution of immune genes in island birds.
Barthe, M.; Doutrelant, C.; Covas, R.; Melo, M.; Illera, J. C.; Tilak, M.-K.; Colombier, C.; Leroy, T.; Loiseau, C.; Nabholz, B.
10.1101/2021.11.21.469450 — evolutionary biology — Posted on 2021-11-22
1069 Human Biopsies in Nanofibrillar Cellulose Hydrogel - A Novel Method for Long-term Tissue Culture
Niklander, J.; Koivuniemi, R.; Stallinger, A.; Kleinegger, F.; Paasonen, L.; Schrom, S.; Liegl-Atzwanger, B.; Zalaudek, I.; von Campe, G.; Singer, G.; Haybaeck, J.; Yliperttula, M.; Rinner, B.
10.1101/2021.11.22.466872 — cell biology — Posted on 2021-11-22
1070 Mitotic Outcomes in Fibrous Environments
Jana, A.; Zhang, H.; Wang, J.; Kapania, R.; Gov, N.; Deluca, J.; Nain, A.
10.1101/2021.11.21.469470 — cell biology — Posted on 2021-11-22
1071 Bovine serum albumin as a resuscitation promoting factor for viable but non-culturable Mycobacterium tuberculosis via the activation of protein kinase A-dependent cellular processes
Morishige, Y.; Murase, Y.; Chikamatsu, K.; Aono, A.; Igarashi, Y.; Shimomura, Y.; Hosoya, M.; Kamada, K.; Yamada, H.; Takaki, A.; Mitarai, S.
10.1101/2021.11.22.468319 — microbiology — Posted on 2021-11-22
1072 Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant
Gaudreault, N. N.; Cool, K.; Trujillo, J. D.; Morozov, I.; Meekins, D. A.; McDowell, C. D.; Bold, D.; Carossino, M.; Balaraman, V.; Mitzel, D.; Kwon, T.; Madden, D. W.; Artiaga, B. L.; Pogranichniy, R.; Roman-Sosa, G.; Wilson, W. C.; Balasuriya, U. B.; Garcia-Sastre, A.; Richt, J. A.
10.1101/2021.11.15.468720 — microbiology — Posted on 2021-11-22
1078 Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits
Yao, H. K.; Guet-McCreight, A.; Mazza, F.; Moradi Chameh, H.; Prevot, T. D.; Griffiths, J.; Tripathy, S. J.; Valiante, T. A.; Sibille, E.; Hay, E.
10.1101/2021.02.17.431698 — neuroscience — Posted on 2021-11-22
1079 Population Imaging of Central Sensitization
Warwick, C. A.; Salsovic, J.; Hachisuka, J.; Smith, K. M. M.; Chen, H.; Ibinson, J. W.; Koerber, H. R.; Ross, S. E.
10.1101/2021.11.21.469166 — neuroscience — Posted on 2021-11-22
1080 Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and non-ischemic human hearts
Parvatiyar, M. S.; Landim-Vieira, M.; Childers, M. C.; Wacker, A. L.; Garcia, M. R.; He, H.; Singh, R.; Brundage, E. A.; Johnston, J. R.; Whitson, B. A.; Chase, P. B.; Janssen, P. M.; Regnier, M.; Biesiadecki, B. J.; Pinto, J. R.
10.1101/2021.11.21.469462 — physiology — Posted on 2021-11-22
1081 Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation
Zhou, S.; Liu, X.; Fang, X.; Chinchilli, V. M.; Wang, M.; Wang, H.-G.; Dokholyan, N. V.; Shen, C.; Lee, J. J.
10.1101/2021.11.20.469388 — pharmacology and toxicology — Posted on 2021-11-22
1082 Laser Ablation and Fluid Flows Show a Single Force Mechanism Governs Spindle Positioning
Wu, H.-Y.; Kabacaoglu, G.; Nazockdast, E.; Chang, H.-C.; Shelley, M. J.; Needleman, D. J.
10.1101/2021.11.21.469320 — biophysics — Posted on 2021-11-22
1085 Protein sequence sampling and prediction from structural data
Orellana, G. A.; Caceres-Delpiano, J.; Ibanez, R.; Dunne, M. P.; Alvarez, L.
10.1101/2021.09.06.459171 — bioinformatics — Posted on 2021-11-22
1086 Nrf2 mediated ER-phagy protects against oxidative damage in intervertebral disc degeneration
lin, z.; ni, l.; teng, c.; zhang, z.; lu, x.; xie, c.; wu, l.; zhou, y.; tian, n.; wu, y.; sun, l.; pan, z.; wang, x.; lin, z.; Zhang, X.
10.1101/2021.11.21.469451 — cell biology — Posted on 2021-11-22
1088 Self-regulation of the brain's right frontal Beta rhythm using a brain-computer interface
Enz, N.; Schmidt, J.; Nolan, K.; Mitchell, M.; Alvarez Gomez, S.; Alkayyali, M.; Cambay, P.; Gippert, M.; Whelan, R.; Ruddy, K. L.
10.1101/2021.10.07.463487 — neuroscience — Posted on 2021-11-22
1090 Optimal information loading into working memory in prefrontal cortex
Stroud, J. P.; Watanabe, K.; Suzuki, T.; Stokes, M. G.; Lengyel, M.
10.1101/2021.11.16.468360 — neuroscience — Posted on 2021-11-22
1092 Longitudinal changes of ADHD symptoms in association with white matter microstructure: a tract-specific fixel-based analysis
Damatac, C. G.; Soheili-Nezhad, S.; Blazquez Freches, G.; Zwiers, M. P.; de Bruijn, S.; Ikde, S.; Portengen, C. M.; Abelmann, A. C.; Dammers, J. T.; van Rooij, D.; Akkermans, S. E. A.; Naaijen, J.; Franke, B.; Buitelaar, J. K.; Beckmann, C. F.; Sprooten, E.
10.1101/2021.11.19.469248 — neuroscience — Posted on 2021-11-22
1093 Atlas of Inhibitory Neurons in the Mouse Brain
Rodarie, D.; Veraszto, C.; Roussel, Y.; Reimann, M.; Keller, D.; Ramaswamy, S.; Gewaltig, M.-O.; Markram, H.
10.1101/2021.11.20.469384 — neuroscience — Posted on 2021-11-22
1098 A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates
Rodriguez, I.; Figueiredo, A. S.; Sousa, M.; Lanza, V. F.; Rodriguez, C.; Mingo, P.; Zamora, J.; Loza, E.; Brooks, C. J.; Canton, R.; Baquero, F.; Coque, T. M.; Aracil-Gisbert, S.; Fernandez de Bobadilla, M. D.
10.1101/2020.04.10.034777 — microbiology — Posted on 2021-11-22
1100 Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts
Tomofuji, K.; Fukumitsu, K.; Kondo, J.; Horie, H.; Makino, K.; Wakama, S.; Ito, T.; Oshima, Y.; Ogiso, S.; Ishii, T.; Inoue, M.; Hatano, E.
10.1101/2021.11.14.468338 — bioengineering — Posted on 2021-11-22
1104 Enhancing daily light exposure increases the antibody response to influenza vaccination in patients with dementia
Munch, M.; Goldbach, R.; Zumstein, N.; Vonmoos, P.; Scartezzini, J.-L.; Wirz-Justice, A.; Cajochen, C.
10.1101/2020.11.30.405175 — immunology — Posted on 2021-11-22
1106 Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo Hemorrhagic Fever Viruses for novel therapeutic target
Neogi, U.; Elaldi, N.; Appelberg, S.; Ambikan, A.; Kennedy, E.; D. Dowall, S.; Bagci, B. K.; Gupta, S.; Rodriguez, J. E.; Svensson-Akusjärvi, S.; Monteil, V.; Vegvari, A.; Benfeitas, R.; Banerjea, A.; Weber, F.; Hewson, R.; Mirazimi, A.
10.1101/2020.12.10.419697 — microbiology — Posted on 2021-11-22
1108 Population differences in the length and early-life dynamics of telomeres among European pied flycatchers
Karkkainen, T.; Laaksonen, T.; Burgess, M.; Cantarero, A.; Martinez-Padilla, J.; Potti, J.; Moreno, J.; Thomson, R. L.; Tilgar, V.; STIER, A.
10.1101/2021.03.16.435615 — zoology — Posted on 2021-11-22
1109 Artificial Intelligence uncovers carcinogenic human metabolites
Mittal, A.; Gautam, V.; S, R.; Arora, S.; Saproo, S.; Gupta, R.; Mohanty, S. K.; Garg, P.; Aggarwal, A.; R, P.; Dixit, N. K.; Singh, V. P.; Mehta, A.; Tayal, J.; Naidu, S.; Sengupta, D.; Ahuja, G.
10.1101/2021.11.20.469412 — bioinformatics — Posted on 2021-11-22
1110 Locus-specific chromatin profiling of evolutionarily young transposable elements
Taylor, D.; Lowe, R. R.; Philippe, C.; Cheng, K. C. L.; Grant, O. A.; Zabet, N. R.; Cristofari, G.; Branco, M. R.
10.1101/2021.08.25.457666 — genomics — Posted on 2021-11-22
1112 Cumulative growth and stress responses to the 2018-2019 drought in a European floodplain forest
Schnabel, F.; Purrucker, S.; Schmitt, L.; Engelmann, R. A.; Kahl, A.; Richter, R.; Seele-Dilbat, C.; Skiadaresis, G.; Wirth, C.
10.1101/2021.03.05.434090 — ecology — Posted on 2021-11-22
1113 Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety
Watari, H.; Kageyama, H.; Masubuchi, N.; Nakajima, H.; Onodera, K.; Focia, P. J.; Oshiro, T.; Matsui, T.; Kodera, Y.; Ogawa, T.; Yokoyama, T.; Hirayama, M.; Hori, K.; Freymann, D. M.; Komatsu, N.; Araki, M.; Tanaka, Y.; Sakai, R.
10.1101/2021.10.29.466502 — cell biology — Posted on 2021-11-22
1114 In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Imanishi, S.; Huang, L.; Itakura, S.; Ishizaka, M.; Iwasaki, Y.; Yamaguchi, T.; Miyamoto-Sato, E.
10.1101/2021.04.23.441075 — molecular biology — Posted on 2021-11-22
1116 Efficient Hydrophilic Small Molecule Delivery To Retinal Cell Lines Using Solid Lipid Nanoparticle Containing Gel Core
Huang, L.; Himawan, E.; Belhadj, S.; Perez Garcia, R. O.; Paquet-Durand, F.; Schipper, N.; Buzgo, M.; Simaite, A.; Marigo, V.
10.1101/2021.05.24.445543 — neuroscience — Posted on 2021-11-22
1117 Functional architecture of the pancreatic islets: First responder cells drive the first-phase response
Kravets, V.; Dwulet, J. M.; Schleicher, W. E.; Hodson, D. J.; Davis, A. M.; Pyle, L.; Piscopio, R. A.; Sticco-Ivins, M.; Benninger, R. K.
10.1101/2020.12.22.424082 — biophysics — Posted on 2021-11-22
1118 Zinc finger protein Zfp335 controls early T cell development and survival through beta-selection-dependent and -independent mechanisms
Wang, X.; Jiao, A.; Su, Y.; Li, W.; Yang, B.; Ding, R.; Zhang, C.; Liu, H.; Yang, X.; Sun, C.; Sun, L.; Zhang, B.
10.1101/2021.11.21.469458 — immunology — Posted on 2021-11-21
1122 Quantitative accuracy and precision in multiplexed single-cell proteomics.
Ctortecka, C.; Stejskal, K.; Krssakova, G.; Mendjan, S.; Mechtler, K.
10.1101/2021.09.03.458853 — biochemistry — Posted on 2021-11-21
1124 Selecting species for restoration in foundational assemblages
Madin, J.; McWilliam, M.; Quigley, K.; Bay, L.; Bellwood, D.; Doropoulos, C.; Fernandes, L.; Harrison, P.; Hoey, A.; Mumby, P.; Richards, Z.; Riginos, C.; Suggett, D.; van Oppen, M.
10.1101/2021.11.03.467181 — ecology — Posted on 2021-11-21
1128 A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity
Kumar, S. T.; Mahul-Mellier, A.-L.; Hegde, R. N.; Moons, R.; Magalhaes, P.; Ibanez de Opakua, A.; Riviere, G.; Rostami, I.; Donzelli, S.; Zweckstetter, M.; Sobott, F.; Lashuel, H. A.
10.1101/2021.11.21.469421 — neuroscience — Posted on 2021-11-21
1129 SMGen: A generator of synthetic models of biochemical reaction networks
Riva, S. G.; Cazzaniga, P.; Nobile, M. S.; Spolaor, S.; Rundo, L.; Besozzi, D.; Tangherloni, A.
10.1101/2021.07.29.454343 — systems biology — Posted on 2021-11-21
1132 Biomechanics of aging and osteoarthritic human knee ligaments
Peters, A. E.; Geraghty, B.; Bates, K. T.; Akhtar, R.; Readioff, R.; Comerford, E.
10.1101/2021.11.21.469435 — bioengineering — Posted on 2021-11-21
1135 Unravelling the regulation pathway of photosynthetic AB-GAPDH
Marotta, R.; Del Giudice, A.; Libero, G.; Fanti, S.; Swec, P.; Galantini, L.; Falini, G.; Trost, P.; Fermani, S.; Sparla, F.
10.1101/2021.11.21.469434 — biochemistry — Posted on 2021-11-21
1141 Stress deceleration theory: chronic adolescent stress exposure results in decelerated neurobehavioral maturation
Jadhav, K.; Hoffman, A.; Burgisser, M.; Rosetti, C.; Aeschlimann, L.; Lupica, C. R.; Boutrel, B.
10.1101/2021.11.21.469381 — neuroscience — Posted on 2021-11-21
1143 Artificial Intelligence uncovers carcinogenic human metabolites
Mittal, A.; Gautam, V.; S, R.; Arora, S.; Saproo, S.; Gupta, R.; Mohanty, S. K.; Garg, P.; Aggarwal, A.; R, P.; Dixit, N. K.; Singh, V. P.; Mehta, A.; Tayal, J.; Naidu, S.; Sengupta, D.; Ahuja, G.
10.1101/2021.11.20.469412 — bioinformatics — Posted on 2021-11-21
1144 Systematic Interrogation of Protein Refolding Under Cellular-Like Conditions
To, P.; Lee, S. O.; Xia, Y.; Devlin, T.; Fleming, K. G.; Fried, S. D.
10.1101/2021.11.20.469408 — biophysics — Posted on 2021-11-21
1148 Respiratory Syncytial virus NS1 protein targets the transactivator binding domain of MED25
Basse, V.; Dong, J.; Peres de Oliveira, A.; Vidalain, P.-O.; Tangy, F.; Galloux, M.; Eleouët, J.-F.; Sizun, C.; Bajorek, M.
10.1101/2021.11.19.469356 — microbiology — Posted on 2021-11-21
1150 Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance
Qu, Y.; Alves-Silva, J.; Gupta, K.; Hahn, I.; Parkin, J.; Sanchez-Soriano, N.; Prokop, A.
10.1101/2021.11.21.469398 — neuroscience — Posted on 2021-11-21
1152 A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity
Kumar, S. T.; Mahul-Mellier, A.-L.; Hegde, R. N.; Moons, R.; Magalhaes, P.; Ibanez de Opakua, A.; Riviere, G.; Rostami, I.; Donzelli, S.; Zweckstetter, M.; Sobott, F.; Lashuel, H. A.
10.1101/2021.11.21.469421 — neuroscience — Posted on 2021-11-21
1153 Auto-CORPus: A Natural Language Processing Tool for Standardising and Reusing Biomedical Literature
Beck, T.; Shorter, T.; Hu, Y.; Li, Z.; Sun, S.; Popovici, C. M.; McQuibban, N. A.; Makraduli, F.; Yeung, C. S.; Rowlands, T.; Posma, J. M.
10.1101/2021.01.08.425887 — bioinformatics — Posted on 2021-11-21
1154 RNA-Seq analysis identifies novel roles for the primary cilia gene SPAG17 and the SOX9 locus non-coding RNAs in systemic sclerosis
Roberson, E. D. O.; Carns, M.; Cao, L.; Aren, K.; Goldberg, I. A.; Morales-Heil, D. J.; Korman, B. D.; Atkinson, J. P.; Varga, J.
10.1101/2021.11.20.468677 — genomics — Posted on 2021-11-21
1155 Specificities and commonalities of carbapenemase producing Escherichia coli isolated in France from 2012 to 2015.
Patino-Navarrete, R.; Rosinski-Chupin, I.; Cabanel, N.; Zongo, p.-d.; Hery, M.; Oueslati, S.; Girlich, D.; Dortet, L.; Bonnin, R.; Naas, T.; Glaser, P.
10.1101/2021.10.19.464995 — microbiology — Posted on 2021-11-21
1156 BAI-Net: Individualized Anatomical Human Cerebral Cartography using Graph Convolutional Network
Ma, L.; Zhang, Y.; Zhang, H.; Cheng, L.; Zhuo, J.; Shi, W.; Lu, Y.; Li, W.; Wang, J.; Yang, Z.; Fan, L.; Jiang, T.
10.1101/2021.07.15.452577 — neuroscience — Posted on 2021-11-21
1157 Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug resistant gliomas
Tiek, D. M.; Erdogdu, B.; Razaghi, R.; Jin, L.; Sadowski, N.; Alamillo-Ferrer, C.; Hogg, J. R.; Haddad, B. R.; Drewry, D. H.; Wells, C. I.; Pickett, J. E.; Song, X.; Goenka, A.; Hu, B.; Goldlust, S. L.; Zuercher, W. J.; Pertea, M.; Timp, W.; Cheng, S.-Y.; Riggins, R. B.
10.1101/661660 — cancer biology — Posted on 2021-11-21
1159 In situ architecture of the ciliary base reveals the stepwise assembly of IFT trains
van den Hoek, H.; Klena, N.; Jordan, M. A.; Alvarez Viar, G.; Schaffer, M.; Erdmann, P. S.; Wan, W.; Plitzko, J. M.; Baumeister, W.; Pigino, G.; Hamel, V.; Guichard, P.; Engel, B. D.
10.1101/2021.10.17.464685 — cell biology — Posted on 2021-11-21
1165 A glycerol shunt functions as a glucose excess security valve in pancreatic β-cells
Al-Mass, A.; Poursharifi, P.; Peyot, M.-L.; Lussier, R.; Levens, E. J.; Guida, J.; Mugabo, Y.; Possik, E.; Ahmad, R.; Al-Mulla, F.; Sladek, R.; Madiraju, S. R. M.; Prentki, M.
10.1101/2021.11.20.468884 — biochemistry — Posted on 2021-11-20
1168 Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition
van Loosdregt, J.; Peeters, J.; Boltjes, A.; Scholman, R.; Vervoort, S.; Coffer, P.; Mokry, M.; Vastert, B.; van Wijk, F.
10.1101/2021.11.20.469222 — immunology — Posted on 2021-11-20
1169 Multi-timescale biological learning algorithms train spiking neuronal network motor control
Hasegan, D.; Deible, M.; Earl, C.; D'Onofrio, D.; Hazan, H.; Anwar, H.; Neymotin, S. A.
10.1101/2021.11.20.469405 — neuroscience — Posted on 2021-11-20
1171 A multiscale X-ray phase-contrast tomography dataset of whole human left lung
Xian, R. P.; Walsh, C. L.; Verleden, S. E.; Wagner, W. L.; Bellier, A.; Marussi, S.; Ackermann, M.; Jonigk, D. D.; Jacob, J.; Lee, P. D.; Tafforeau, P.
10.1101/2021.11.20.469361 — physiology — Posted on 2021-11-20
1173 Fast DNA-PAINT imaging using a deep neural network
Narayanasamy, K. K.; Rahm, J. V.; Tourani, S.; Heilemann, M.
10.1101/2021.11.20.469366 — biophysics — Posted on 2021-11-20
1175 Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity
Li, D.; Brackenridge, S.; Walters, L. C.; Swanson, O.; Harlos, K.; Rozbesky, D.; Cain, D. W.; Wiehe, K.; Scearce, R. M.; Barr, M.; Mu, Z.; Parks, R.; Quastel, M.; Edwards, R. J.; Wang, Y.; Rountree, W.; Saunders, K. O.; Ferrari, G.; Borrow, P.; Jones, E. Y.; Alam, S. M.; Azoitei, M. L.; Gillespie, G. M.; McMichael, A. J.; Haynes, B. F.
10.1101/2020.12.03.403014 — immunology — Posted on 2021-11-20
1176 Bilaterally Reduced Rolandic Beta Band Activity in Minor Stroke Patients
Kulasingham, J. P.; Brodbeck, C.; Khan, S.; Marsh, E. B.; Simon, J. Z.
10.1101/2021.10.15.464457 — neuroscience — Posted on 2021-11-20
1181 Binding stoichiometry and structural model of the HIV-1 Rev/Importin beta complex
Spittler, D.; Indorato, R.-L.; Boeri Erba, E.; Delaforge, E.; Signor, L.; Harris, S. J.; Garcia Saez, I.; PALENCIA, A.; Gabel, F.; Blackledge, M.; Noirclerc-Savoye, M.; Petosa, C.
10.1101/2021.11.16.468785 — biochemistry — Posted on 2021-11-20
1182 Heat activation and inactivation of bacterial spores. Is there an overlap?
Wen, J.; Smelt, J. P. P. M.; Vischer, N. O. E.; Vos, A. D.; Setlow, P.; Brul, S.
10.1101/2021.11.20.469368 — microbiology — Posted on 2021-11-20
1187 Shank3 influences mammalian sleep development
Medina, E.; Schoch, H.; Wintler, T. P.; Ford, K. E.; Singletary, K. G.; Peixoto, L.
10.1101/2021.03.10.434728 — neuroscience — Posted on 2021-11-20
1190 A ROS-Ca2+ signalling pathway identified from a chemical screen for modifiers of sugar-activated circadian gene expression.
Li, X.; Deng, D.; Cataltepe, G.; Roman, A.; Cassano Monte Bello, C.; Skirycz, A.; Caldana, C.; Haydon, M. J.
10.1101/2021.11.20.469363 — plant biology — Posted on 2021-11-20
1191 The annotation and analysis of complex 3D plant organs using 3DCoordX
Vijayan, A.; Strauss, S.; Tofanelli, R.; Mody, T. A.; Lee, K.; Tsiantis, M.; Smith, R. S.; Schneitz, K.
10.1101/2021.11.20.469364 — plant biology — Posted on 2021-11-20
1195 Strict adherence to Mendel's First Law across a large sample of human sperm genomes
Carioscia, S. A.; Weaver, K. J.; Bortvin, A. N.; Ariad, D.; Bell, A. D.; McCoy, R. C.
10.1101/2021.11.19.469261 — genomics — Posted on 2021-11-20
1197 Circadian regulation of lung repair and regeneration
Naik, A.; Forrest, K.; Issah, Y.; Valekunja, U.; Reddy, A. B.; Hennessy, E.; Brooks, T.; Babu, A.; Morley, M.; Grant, G. R.; FitzGerald, G. A.; Sehgal, A.; Worthen, G. S.; Frank, D. B.; Morrisey, E. E.; Sengupta, S.
10.1101/2021.11.20.469376 — cell biology — Posted on 2021-11-20
1205 Glutamate-Weighted Magnetic Resonance Imaging (GluCEST) Detects Effects of Transcranial Magnetic Stimulation to the Motor Cortex
Cember, A. T. J.; Deck, B. L.; Kelkar, A. S.; Faseyitan, O.; Zimmerman, J. P.; Erickson, B. A.; Elliot, M. A.; Coslett, B.; Hamilton, R. H.; Reddy, R.; Medaglia, J. D.
10.1101/2021.11.18.469133 — neuroscience — Posted on 2021-11-20
1211 Disruption Of Proprioceptive Information During Electrical Stimulation Of The Cutaneous Afferents
Katic, N.; Balaguer, J.-M.; Gorskii, O.; Pavlova, N.; Karal-ogly, D.; Bulgin, D.; Orlov, S.; Musienko, P.; Raspopovic, S.; Capogrosso, M.
10.1101/2021.11.19.469209 — neuroscience — Posted on 2021-11-20
1212 Assessment of temporal complexity in functional MRI between rest and task conditions
Omidvarnia, A.; Liegeois, R.; Amico, E.; Preti, G.; Zalesky, A.; Van De Ville, D.
10.1101/2021.11.20.469367 — bioengineering — Posted on 2021-11-20
1213 Doppler Slicing for Ultrasound Super-Resolution Without Contrast Agents
Bar-Zion, A.; Solomon, O.; Rabut, C.; Maresca, D.; Eldar, Y. C.; Shapiro, M. G.
10.1101/2021.11.19.469083 — bioengineering — Posted on 2021-11-20
1214 Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue
Honecker, J.; Ruschke, S.; Seeliger, C.; Laber, S.; Strobel, S.; Proell, P.; Nellaker, C.; Lindgren, C.; Kulozik, U.; Ecker, J.; Karampinos, D.; Claussnitzer, M.; Hauner, H.
10.1101/2021.11.20.468818 — cell biology — Posted on 2021-11-20
1215 The effect of external stimulation on functional networks in the aging healthy human brain
Escrichs, A.; Perl, Y. S.; Martinez-Molina, N.; Biarnes, C.; Garre, J.; Fernandez-Real, J. M.; Ramos, R.; Marti, R.; Pamplona, R.; Brugada, R.; Serena, J.; Ramio-Torrenta, L.; Coll, G.; Gallart, L.; Barretina, J.; Vilanova, J.; Mayneris-Perxachs, J.; Saba, L.; Pedraza, S.; Kringelbach, M. L.; Puig, J.; Deco, G.
10.1101/2021.11.19.469206 — neuroscience — Posted on 2021-11-20
1218 Heat stress leads to rapid lipid remodelling and transcriptional adaptations in Nicotiana tabacum pollen tubes
Krawczyk, H. E.; Rotsch, A. H.; Herrfurth, C.; Scholz, P.; Shomroni, O.; Salinas-Riester, G.; Feussner, I.; Ischebeck, T.
10.1101/2021.11.18.469149 — plant biology — Posted on 2021-11-20
1219 Self-organization of in vitro neuronal assemblies drives to complex network topology
Correa Antonello, P.; Varley, T. F.; Beggs, J.; Porcionatto, M.; Sporns, O.; Faber, J.
10.1101/2021.11.17.468951 — neuroscience — Posted on 2021-11-20
1220 The natural compound TMYX reduces SAN cells rate by antagonizing the cAMP modulation of f-channels
Piantoni, C.; Paina, M.; Molla, D.; Liu, S.; Bertoli, G.; Jiang, H.; Wang, Y.; Wang, Y.; Wang, Y.; DiFrancesco, D.; Barbuti, A.; Bucchi, A.; Baruscotti, M.
10.1101/2021.11.16.468855 — physiology — Posted on 2021-11-20
1223 Mosaic loss of chromosome Y in aged human microglia.
Vermeulen, M. C.; Pearse, R.; Young-Pearse, T.; Mostafavi, S.
10.1101/2021.11.19.469312 — genomics — Posted on 2021-11-20
1226 A tripartite structure, the complex nuclear receptor element (cNRE), is a cis-regulatory module of viral origin required for atrial chamber preferential gene expression
Nunes Santos, L.; Costa, A.; Nikolov, M.; Sampaio, A. C.; Stockdale, F.; Castillo, H. A.; Grizante, M. B.; Dudczig, S.; Vasconcelos, M.; Rosenthal, N.; Jusuf, P. R.; Lopes-de-Oliveira, P.; Matos, T.; Nikovits, W.; Schubert, M.; Ramialison, M.; Xavier-Neto, J.
10.1101/2021.11.18.469087 — developmental biology — Posted on 2021-11-20
1228 Systems medicine dissection of chromosome 1q amplification reveals oncogenic regulatory circuits and informs targeted therapy in cancer
Trasanidis, N.; Katsarou, A.; Ponnusamy, K.; Shen, Y.-A.; Kostopoulos, I. V.; Bergonia, B.; Keren, K.; Reema, P.; Xiao, X.; Szydlo, R. M.; Sabbattini, P. M.; Roberts, I. A.; Auner, H. W.; Naresh, K. N.; Chaidos, A.; Wang, T.-L.; Magnani, L.; Caputo, V. S.; Karadimitris, A.
10.1101/2021.11.17.469031 — cancer biology — Posted on 2021-11-20
1232 LiGIoNs: A Computational Method for the Detection and Classification of Ligand-Gated Ion Channels
Apostolakou, A. E.; Nastou, K. C.; Petichakis, G. N.; Litou, Z. I.; Iconomidou, V. A.
10.1101/833350 — bioinformatics — Posted on 2021-11-20
1236 On the hindlimb biomechanics of the avian take-off leap
Meilak, E. A.; Provini, P.; Palmer, C.; Gostling, N. J.; Heller, M. O.
10.1101/2021.11.19.469279 — bioengineering — Posted on 2021-11-20
1238 Genetic mapping of genotype-by-ploidy effects in Arabidopsis thaliana
Wijnen, C. L.; Becker, F. F. M.; Okkersen, A. A.; de Snoo, B. C.; Boer, M. P.; van Eeuwijk, F.; Wijnker, T.; Keurentjes, J. J. B.
10.1101/2021.11.19.469311 — genetics — Posted on 2021-11-20
1241 CLASS-II KNOX genes coordinate spatial and temporal patterns of the tomato ripening
Keren-Keiserman, A.; Shtern, A.; Chalupowicz, D.; Furumizu, C.; Alvarez, J. p.; Amsellem, Z.; Arazi, T.; Tuvia-Alkalai, S.; Efroni, I.; Fallik, E.; Goldshmidt, A.
10.1101/2021.11.19.469310 — developmental biology — Posted on 2021-11-20
1248 Fertility costs of cryptic viral infections in a model social insect
Chapman, A.; Amiri, E.; Han, B.; McDermott, E.; Rueppell, O.; Tarpy, D. R.; Foster, L.; McAfee, A.
10.1101/2021.05.04.442681 — systems biology — Posted on 2021-11-20
1249 Smart soils to observe hidden rhizosphere processes
Patko, D.; Yang, Q.; Liu, Y.; Falireas, P.; Briou, B.; Tawade, B. V.; George, T. S.; Daniell, T. J.; MacDonald, M. P.; Ladmiral, V.; Ameduri, B.; Dupuy, L. X.
10.1101/2021.11.19.468202 — plant biology — Posted on 2021-11-19
1251 Partial prevention of glucocorticoid-induced osteocyte deterioration with osteocrin gene therapy
Mazur, C. M.; Castro Andrade, C. D.; Sato, T.; Bruce, M.; Bouxsein, M. L.; Wang, J. S.; Wein, M. N.
10.1101/2021.11.19.469265 — physiology — Posted on 2021-11-20
1253 A chemerin peptide analog stimulates tumor growth in two xenograft mouse models of human colorectal carcinoma
Friebus-Kardash, J.; Schulz, P.; Reinicke, S.; Karthaus, C.; Schefer, Q.; Bandholtz, S.; Groetzinger, C.
10.1101/2021.11.19.469262 — cancer biology — Posted on 2021-11-20
1255 Restoring single-molecule localizations with wavefront sensing adaptive optics for deep-tissue super-resolution imaging
Park, S.; Jo, Y.; Kang, M.; Hong, J. H.; Ko, S.; Kim, S.; Park, S.; Park, H.-C.; Shim, S.-H.; Choi, W.
10.1101/2021.11.18.469175 — cancer biology — Posted on 2021-11-20
1257 nucGEMs probe the biophysical properties of the nucleoplasm
Szoradi, T.; Shu, T.; Kidiyoor, G. R.; Xie, Y.; Herzog, N. L.; Bazley, A.; Bonucci, M.; Keegan, S.; Saxena, S.; Ettefa, F.; Brittingham, G. P.; Lemiere, J.; Fenyo, D.; Chang, F.; Delarue, M.; Holt, L. J.
10.1101/2021.11.18.469159 — biophysics — Posted on 2021-11-20
1258 TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-binding analyses
Wu, K. E.; Yost, K. E.; Daniel, B.; Belk, J. A.; Xia, Y.; Egawa, T.; Satpathy, A.; Chang, H.; Zou, J.
10.1101/2021.11.18.469186 — bioinformatics — Posted on 2021-11-20
1260 Robust Identification of Temporal Biomarkers in Longitudinal Omics Studies
Metwally, A. A.; Zhang, T.; Wu, S.; Kellogg, R.; Zhou, W.; Tang, H.; Snyder, M.
10.1101/2021.11.19.469350 — bioinformatics — Posted on 2021-11-20
1264 A genome assembly of the Atlantic chub mackerel (Scomber colias): a valuable teleost fishing resource
Machado, A.; Gomes-dos-Santos, A.; Fonseca, M.; Fonseca, R. d.; Verissimo, A.; Felicio, M.; Capela, R.; Alves, N.; Santos, M.; Salvador-Caramelo, F.; Domingues, M.; Ruivo, R.; Froufe, E.; Castro, F.
10.1101/2021.11.19.468211 — genomics — Posted on 2021-11-20
1269 T cell-intrinsic vitamin A metabolism and its signaling are targets for memory T cell-based cancer immunotherapy
Fujiki, F.; Morimoto, S.; Katsuhara, A.; Okuda, A.; Ogawa, S.; Ueda, E.; Miyazaki, M.; Isotani, A.; Ikawa, M.; Nishida, S.; Nakajima, H.; Tsuboi, A.; Oka, Y.; Nakata, J.; Hosen, N.; Kumanogoh, A.; Oji, Y.; Sugiyama, H.
10.1101/2021.11.19.469290 — immunology — Posted on 2021-11-20
1270 Insights into the trafficking of human leukocytes to colostrum evidences a modulation of the B lymphocyte compartment in obesity
Piñeiro-Salvador, R.; Vazquez-Garza, E.; Cruz-Cardenas, J. A. C.-C.; García-Rivas, G. d. J.; Moreno-Vásquez, J.; Alcorta-García, M. R.; Licona-Cassani, C.; Lara-Diaz, V. J.; Brunck, M. E. G.
10.1101/2021.11.19.469333 — immunology — Posted on 2021-11-20
1271 Antigen presentation by type 3 innate lymphoid cells instructs the differentiation of gut microbiota-specific regulatory T cells
Kedmi, R.; Najar, T.; Mesa, K. R.; Grayson, A.; Kroehling, L.; Hao, Y.; Hao, S.; Pokrovskii, M.; Xu, M.; Talbot, J.; Wang, J.; Anderson, M. S.; Gardner, J. M.; Laufer, T. M.; Aifantis, I.; Bartleson, J. M.; Allen, P. M.; Stoeckius, M.; Littman, D. R.
10.1101/2021.11.19.469318 — immunology — Posted on 2021-11-20
1272 Algorithmic Parameter Estimation and Uncertainty Quantification for Hodgkin-Huxley Neuron Models
Wang, Y. C.; Sinha, N.; Rudi, J.; Velasco, J.; Idumah, G.; Powers, R. K.; Heckman, C. J.; Chardon, M.
10.1101/2021.11.18.469189 — neuroscience — Posted on 2021-11-20
1273 Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome
Mesnage, R.; Panzacchi, S.; Bourne, E.; Mein, C. A.; Perry, M.; Hu, J.; Chen, J.; Mandrioli, D.; Belpoggi, F.; Antoniou, M. N.
10.1101/2021.11.19.468976 — pharmacology and toxicology — Posted on 2021-11-19
1274 Proteolysis Targeting Chimeras With Reduced Off-targets
Nguyen, T. M.; Deb, A.; Kokkonda, P.; Sreekanth, V.; Tiwari, P. K.; Shoba, V. M.; Lai, S.; Chaudhary, S. K.; Mercer, J. A. M.; Jan, M.; Liu, D. R.; Ebert, B. L.; Choudhary, A.
10.1101/2021.11.18.468552 — pharmacology and toxicology — Posted on 2021-11-20
1276 Cell Painting predicts impact of lung cancer variants
Caicedo, J. C.; Arevalo, J.; Piccioni, F.; Bray, M.-A.; Hartland, C. L.; Wu, X.; Brooks, A. N.; Berger, A.; Boehm, J. S.; Carpenter, A. E.; Singh, S.
10.1101/2021.11.18.469171 — cancer biology — Posted on 2021-11-20
1281 Adaptive ratchets and the evolution of molecular complexity
Röschinger, T.; Moran Tovar, R.; Pompei, S.; Lässig, M.
10.1101/2021.11.18.469165 — biophysics — Posted on 2021-11-20
1286 STRling: a k-mer counting approach that detects short tandem repeat expansions at known and novel loci
Dashnow, H.; Pedersen, B. S.; Hiatt, L.; Brown, J.; Beecroft, S. J.; Ravenscroft, G.; LaCroix, A. J.; Lamont, P.; Roxburgh, R. H.; Rodrigues, M. J.; Davis, M.; Mefford, H. C.; Laing, N. G.; Quinlan, A. R.
10.1101/2021.11.18.469113 — bioinformatics — Posted on 2021-11-20
1288 Swarm learning for decentralized artificial intelligence in cancer histopathology
Saldanha, O. L.; Quirke, P.; West, N. P.; James, J. A.; Loughrey, M. B.; Grabsch, H. I.; Salto-Tellez, M.; Alwers, E.; Cifci, D.; Ghaffari Laleh, N.; Seibel, T.; Gray, R.; Hutchins, G. G. A.; Brenner, H.; Yuan, T.; Brinker, T. J.; Chang-Claude, J.; Khader, F.; Schuppert, A.; Luedde, T.; Foersch, S.; Muti, H. S.; Trautwein, C.; Hoffmeister, M.; Truhn, D.; Kather, J. N.
10.1101/2021.11.19.469139 — bioinformatics — Posted on 2021-11-20
1289 Parental control: ecology drives plasticity in parental response to offspring signals
Caro, S.; Velasco, A. C.; van Mastrigt, T.; van Oers, K.; Griffin, A. S.; West, S. A.; Hinde, C. A.
10.1101/2021.11.18.464426 — animal behavior and cognition — Posted on 2021-11-20
1290 Admixture has obscured signals of historical hard sweeps in humans
Souilmi, Y.; Tobler, R.; Johar, A.; Williams, M.; Grey, S. T.; Schmidt, J.; Teixeira, J. C.; Rohrlach, A.; Tuke, J.; Johnson, O. L.; Gower, G. R.; Turney, C.; Cox, M.; Cooper, A.; Huber, C. D.
10.1101/2020.04.01.021006 — genomics — Posted on 2021-11-19
1293 A 1-bp deletion in bovine QRICH2 causes low sperm count and immotile sperm with multiple morphological abnormalities
Hiltpold, M.; Janett, F.; Mapel, X. M.; Kadri, N. K.; Fang, Z.-H.; Schwarzenbacher, H.; Seefried, F.; Spengeler, M.; Witschi, U.; Pausch, H.
10.1101/2021.11.19.469233 — genetics — Posted on 2021-11-19
1294 Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis
Popova, J. V.; Pavlova, G. A.; Razuvaeva, A. V.; Yarinich, L. A.; Andreyeva, E. N.; Anders, A. F.; Galimova, Y.; Renda, F.; Somma, M. P.; Pindyurin, A. V.; Gatti, M.
10.1101/2021.11.19.469214 — genetics — Posted on 2021-11-20
1297 Historical specimens and the limits of subspecies phylogenomics in the New World quails (Odontophoridae)
Salter, J. F.; Hosner, P. A.; Braun, E. L.; Kimball, R. T.; Brumfield, R. T.; Faircloth, B. C.
10.1101/2021.11.18.468700 — evolutionary biology — Posted on 2021-11-20
1301 Paraxial mesoderm organoids model development of human somites
Budjan, C.; Liu, S.; Ranga, A.; Gayen, S.; Pourquie, O.; Hormoz, S.
10.1101/2021.03.22.436471 — developmental biology — Posted on 2021-11-19
1302 Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies
Choi, Y.; Kim, M. S.; Rhoades, J. H.; Johnson, N. M.; Berry, C. T.; Root, S.; Chen, Q.; Tian, Y.; Fernandez, R. J.; Cramer, Z.; Adams-Tzivelekidis, S.; Li, N.; Johnson, F. B.; Lengner, C. J.
10.1101/2021.11.19.469258 — cell biology — Posted on 2021-11-20
1304 The spotlight of attention turns from rhythmic exploration-exploitation to a stable exploitation state
Melcon, M.; van Bree, S.; Sanchez-Carro, Y.; Barreiro-Fernandez, L.; Kolibius, L. D.; Alzueta, E.; Wimber, M.; Capilla, A.; Hanslmayr, S.
10.1101/2021.11.18.469122 — neuroscience — Posted on 2021-11-19
1305 Longitudinal changes of ADHD symptoms in association with white matter microstructure: a tract-specific fixel-based analysis
Damatac, C. G.; Soheili-Nezhad, S.; Blazquez Freches, G.; Zwiers, M. P.; de Bruijn, S.; Ikde, S.; Portengen, C. M.; Abelmann, A. C.; Dammers, J. T.; van Rooij, D.; Akkermans, S. E. A.; Naaijen, J.; Franke, B.; Buitelaar, J. K.; Beckmann, C. F.; Sprooten, E.
10.1101/2021.11.19.469248 — neuroscience — Posted on 2021-11-19
1306 Vagus nerve stimulation accelerates motor learning through cholinergic modulation
Bowles, S.; Hickman, J.; Peng, X.; Williamson, W. R.; Huang, R.; Washington, K.; Donegan, D.; Welle, C.
10.1101/2021.10.28.466306 — neuroscience — Posted on 2021-11-19
1312 Lateralized phenotypic differences after intrahippocampal kainic acid injection in female mice
Cutia, C. A.; Leverton, L. K.; Ge, X.; Youssef, R.; Raetzman, L. T.; Christian-Hinman, C. A.
10.1101/2021.09.09.459684 — neuroscience — Posted on 2021-11-19
1313 Analytical kinetic model of native tandem promoters in E. coli
Chauhan, V.; Mohamed Bahrudeen, M. N.; Palma, C. S. D.; Baptista, I. S. C.; Lima de Brito Almeida, B.; Dash, S.; Kandavalli, V.; Ribeiro, A. S.
10.1101/2021.11.19.468961 — systems biology — Posted on 2021-11-19
1316 De-noising Spatial Transcriptomics Data Based on Position and Image Information
Wang, Y.; Song, B.; Wang, S.; Chen, M.; Xie, Y.; Xiao, G.; Wang, L.; Wang, T.
10.1101/2021.11.03.467103 — bioinformatics — Posted on 2021-11-19
1319 Scoping the Line Up: A Comparison of Biomonitoring Methodologies for Surf Zone Fish Communities
Gold, Z.; Koch, M. Q.; Schooler, N. K.; Emery, K. A.; Dugan, J. E.; Miller, R. J.; Page, H. M.; Schroeder, D. M.; Hubbard, D. M.; Madden, J. R.; Whitaker, S. G.; Barber, P. H.
10.1101/2021.11.19.469341 — ecology — Posted on 2021-11-19
1320 STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
Dinarello, A.; Betto, R. M.; Cioccarelli, C.; Diamante, L.; Meneghetti, G.; Peron, M.; Tesoriere, A.; Laquatra, C.; Tiso, N.; Martello, G.; Argenton, F.
10.1101/2021.11.19.469257 — developmental biology — Posted on 2021-11-19
1321 Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation
Thompson, A. F.; Blackburn, P. R.; Babovic-Vuksanovic, D.; Lian, J. B.; Klee, E. W.; Stumpff, J.
10.1101/2021.09.29.462402 — cell biology — Posted on 2021-11-19
1322 Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity
Guet-McCreight, A.; Chameh, H. M.; Mahallati, S.; Wishart, M.; Tripathy, S. J.; Valiante, T. A.; Hay, E.
10.1101/2021.11.03.467014 — neuroscience — Posted on 2021-11-19
1323 The heart rate discrimination task: a psychophysical method to estimate the accuracy and precision of interoceptive beliefs
Legrand, N.; Nikolova, N.; Correa, C.; Braendholt, M.; Stuckert, A.; Kildahl, N.; Vejlo, M.; Fardo, F.; Allen, M.
10.1101/2021.02.18.431871 — neuroscience — Posted on 2021-11-19
1328 Pre-implantation mouse embryo movement under hormonally altered conditions
Lufkin, H.; Flores, D.; Raider, Z.; Madhavan, M.; Dawson, M.; Coronel, A.; Sharma, D.; Arora, R.
10.1101/2021.11.19.469319 — developmental biology — Posted on 2021-11-19
1333 Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection
Weindel, C. G.; Zhao, X.; Martinez, E.; Bell, S. L.; Vail, K. J.; Coleman, A. K.; VanPortfliet, J. J.; Zhao, B.; Mabry, C.; Li, P.; West, P.; Karpac, J.; Patrick, K. L.; Watson, R. O.
10.1101/2021.11.18.469014 — immunology — Posted on 2021-11-19
1335 Fusobacterium nucleatum infection induces pancreatic cancer cell proliferation and migration through regulation of host cytokine signaling
Udayasuryan, B.; Nguyen, T. T. D.; Umana, A.; Roberts, L. M.; Ahmad, R. A.; Sobol, P.; Jones, S. D.; Munson, J. M.; Slade, D. J.; Verbridge, S. S.
10.1101/2021.11.19.469245 — cancer biology — Posted on 2021-11-19
1336 TK216 targets microtubules in Ewing sarcoma cells
Povedano Selfa, J. M.; Li, V.; Lake, K. E.; Bai, X.; Rallabandi, R.; Kim, J.; Xie, Y.; De Brabander, J. K.; McFadden, D. G.
10.1101/2021.11.19.469182 — cancer biology — Posted on 2021-11-19
1341 Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to G protein-coupled receptor agonists and accelerates thrombus formation in vivo
Elgheznawy, A.; Oeftering, P.; Englert, M.; Kaiser, F.; Kusch, C.; Gbureck, U.; Boesl, M. R.; Nieswandt, B.; Voegtle, T.; Hermanns, H. M.
10.1101/2021.11.19.469234 — biochemistry — Posted on 2021-11-19
1343 The sperm protein Spaca6 is essential for fertilization in zebrafish
Binner, M. I.; Kogan, A.; Panser, K.; Schleiffer, A.; Deneke, V. E.; Pauli, A.
10.1101/2021.11.19.469324 — developmental biology — Posted on 2021-11-19
1344 Enhancer and super-enhancer landscape in polycystic kidney disease
Lakhia, R.; Mishra, A.; Biggers, L.; Malladi, V.; Cobo-Stark, P.; Hajarnis, S.; Patel, V.
10.1101/2021.11.19.469306 — molecular biology — Posted on 2021-11-19
1346 TAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease
MacDonald, B. T.; Keshishian, H.; Mundorff, C. C.; Arduini, A.; Lai, D.; Bendinelli, K.; Popp, N. R.; Bhandary, B.; Clauser, K. R.; Specht, H.; Elowe, N. H.; Laprise, D.; Xing, Y.; Kaushik, V. K.; Carr, S. A.; Ellinor, P. T.
10.1101/2021.11.19.469331 — molecular biology — Posted on 2021-11-19
1347 RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity
Xu, D.; Feng, S.; Ma, S.; Li, K.; Gao, S.; Ning, S.; Shang, J.; Guo, R.; Li, Q.; Guo, R.; Blumenfeld, B.; Simon, I.
10.1101/2021.11.19.469338 — molecular biology — Posted on 2021-11-19
1352 Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model
Siwczak, F.; Cseresnyes, Z.; Carlstedt, S.; Sigmund, A.; Groeger, M.; Surewaard, B. G. J.; Werz, O.; Figge, M. T.; Tuchscherr, L.; Loeffler, B.; Mosig, A.
10.1101/2021.11.19.469246 — microbiology — Posted on 2021-11-19
1357 Eliminating fibroblast activation protein-α expressing cells by photoimmunotheranostics
Jin, J.; Barnett, J. D.; Krishnamachary, B.; Mironchik, Y.; Luo, C. K.; Kobayashi, H.; Bhujwalla, Z. M.
10.1101/2021.11.18.469110 — cancer biology — Posted on 2021-11-19
1361 DeepProjection: Rapid and structure-specific projections of tissue sheets embedded in 3D microscopy stacks using deep learning
Haertter, D.; Wang, X.; Fogerson, S. M.; Ramkumar, N.; Crawford, J. M.; Poss, K. D.; Di Talia, S.; Kiehart, D. P.; Schmidt, C. F.
10.1101/2021.11.17.468809 — developmental biology — Posted on 2021-11-19
1362 A non-transcriptional function of Yap orchestrates the DNA replication program
Melendez Garcia, R.; Haccard, O.; Chesneau, A.; Narassimprakash, H.; Roger, J. E.; Perron, M.; Marheineke, K.; Bronchain, O.
10.1101/2021.11.18.468628 — developmental biology — Posted on 2021-11-19
1369 BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity
Hickman, T. L.; Choi, E.; Whiteman, K. R.; Muralidharan, S.; Pai, T.; Johnson, T.; Parikh, A.; Friedman, T.; Gilbert, M.; Shen, B.; Barron, L.; McGinness, K. E.; Ettenberg, S. A.; Motz, G. T.; Weiss, G. J.; Jensen-Smith, A.
10.1101/2021.11.17.469041 — cancer biology — Posted on 2021-11-19
1370 Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis.
Carretero-Gonzalez, A.; Sanchez-Redondo, S.; Sanchez, L. M.; Gil, E. C.; Castellano, D.; Hergueta-Redondo, M.; de Velasco, G.; Peinado, H.
10.1101/2021.11.18.469115 — cancer biology — Posted on 2021-11-19
1371 Double mutant of chymotrypsin inhibitor 2 stabilized through increased conformational entropy
Gavrilov, Y.; Kümmerer, F.; Orioli, S.; Prestel, A.; Lindorff-Larsen, K.; Teilum, K.
10.1101/2021.11.18.469114 — biophysics — Posted on 2021-11-19
1377 ZARP: An automated workflow for processing of RNA-seq data
Katsantoni, M.; Gypas, F.; Herrmann, C. J.; Burri, D.; Bak, M.; Iborra, P.; Agarwal, K.; Ataman, M.; Boersch, A.; Zavolan, M.; Kanitz, A.
10.1101/2021.11.18.469017 — bioinformatics — Posted on 2021-11-19
1379 Ecological changes have driven biotic exchanges across the Indian Ocean
Bernardes, S. C.; von Rintelen, K.; von Rintelen, T.; Pepato, A. R.; Page, T. J.; de Bruyn, M.
10.1101/2021.11.18.469077 — evolutionary biology — Posted on 2021-11-19
1380 Multiple adaptive solutions to face climatic constraints: novel insights in the debate over the role of convergence in local adaptation
Benjelloun, B.; Leempoel, K.; Boyer, F.; Stucki, S.; Streeter, I.; Orozco ter Wengel, P.; Alberto, F. J.; Servin, B.; Biscarini, F.; Alberti, A.; Engelen, S.; Stella, A.; Colli, L.; Coissac, E.; Bruford, M. W.; Ajmone-Marsan, P.; Negrini, R.; Clarke, L.; Flicek, P.; Chikhi, A.; Joost, S.; Taberlet, P.; Pompanon, F.
10.1101/2021.11.18.469099 — evolutionary biology — Posted on 2021-11-19
1381 The influence of somatosensory and auditory evoked potentials on concurrent transcranial-magnetic stimulation electroencephalography recordings
Chowdhury, N. S.; Rogasch, N. C.; Chiang, A.; Millard, S. K.; Skippen, P.; Chang, W.-J.; Bilska, K.; Si, E.; Seminowicz, D. A.; Schabrun, S. M.
10.1101/2021.11.17.469035 — neuroscience — Posted on 2021-11-19
1384 Towards a catalog of pome tree architecture genes: the draft 'd'Anjou' genome (Pyrus communis L.)
Zhang, H.; Wafula, E. K.; Eilers, J.; Harkess, A.; Ralph, P. E.; Timilsena, P. R.; dePamphilis, C.; Waite, J.; Honaas, L. A.
10.1101/2021.11.17.467977 — plant biology — Posted on 2021-11-19
1389 Mechanistic insights into global suppressors of protein folding defects
Chattopadhyay, G.; Bhowmick, J.; Manjunath, K.; Ahmed, S.; Goyal, P.; Varadarajan, R.
10.1101/2021.11.18.469098 — biophysics — Posted on 2021-11-19
1390 VIVID: a web application for variant interpretation and visualisation in multidimensional analyses
Tichkule, S.; Myung, Y.; Naung, M. T.; Ansell, B. R.; Guy, A.; Srivastava, N.; Mehra, S.; Caccio, S. M.; Mueller, I.; Barry, A. E.; van Oosterhout, C.; Pope, B.; Ascher, D. B.; Jex, A.
10.1101/2021.11.16.468904 — bioinformatics — Posted on 2021-11-19
1392 Evaluating the contribution of aestivation to the persistence of malaria mosquitoes through the Sahelian dry season using stable isotopes
Faiman, R.; YARO, A. S.; Dao, A.; Sanogo, Z. L.; Diallo, M.; Samake, D.; Yossi, O.; Veru, L. R.; Graber, L. C.; Conte, A. R.; Kouam, C.; Krajacich, B. J.; Lehmann, T.
10.1101/2021.11.17.468867 — ecology — Posted on 2021-11-19
1394 Impaired oligodendrocyte maturation is an early feature in SCA3 disease pathogenesis
Schuster, K. H.; Zalon, A. J.; Zhang, H.; DiFranco, D. M.; Stec, N. R.; Haque, Z.; Blumenstein, K. G.; Pierce, A. M.; Guan, Y.; Paulson, H.; McLoughlin, H. S.
10.1101/2021.11.18.468958 — neuroscience — Posted on 2021-11-19
1396 Not so fast: Limited validity of deep convolutional neural networks as in silico models for human naturalistic face processing
Jiahui, G.; Feilong, M.; Visconti di Oleggio Castello, M.; Nastase, S. A.; Haxby, J. V.; Gobbini, M. I.
10.1101/2021.11.17.469009 — neuroscience — Posted on 2021-11-19
1399 Awake ripples enhance emotional memory encoding in the human brain
Zhang, H.; Skelin, I.; Ma, S.; Paff, M.; Yassa, M. A.; Knight, R. T.; Lin, J. J.
10.1101/2021.11.17.469047 — neuroscience — Posted on 2021-11-19
1403 Nanoviricides platform technology based NV-CoV-2 polymer increases the half-life of Remdesivir in vivo
Chakraborty, A.; Diwan, A.; Arora, V.; Thakur, Y.; Chiniga, V.; Tatake, J.; Holkar, P.; Holkar, N.; Pond, B.
10.1101/2021.11.17.468980 — pharmacology and toxicology — Posted on 2021-11-19
1411 Modulation of hippocampal network oscillation by PICK1-dependent cell surface expression of mGlu3 receptors
Tuduri, P.; Bouquier, N.; Girard, B.; Moutin, E.; Thouaye, M.; Perroy, J.; Bertaso, F.; Ster, J.
10.1101/2021.11.19.469240 — neuroscience — Posted on 2021-11-19
1412 Readout of a spatial memory by interruption of ramping activity in the retrohippocampal cortex
Tennant, S.; Clark, H.; Hawes, I.; Tam, W. K.; Hua, J.; Yang, W.; Gerlei, K.; Wood, E.; Nolan, M. F.
10.1101/2021.03.15.435518 — neuroscience — Posted on 2021-11-19
1413 PBN-PVT projection modulates negative affective states in mice
Zhu, Y.-B.; Wang, Y.; Hua, X.-X.; Xu, L.; Liu, M.-Z.; Zhang, R.; Liu, P.-F.; Li, J.-B.; Zhang, L.; Mu, D.
10.1101/2021.03.11.434900 — neuroscience — Posted on 2021-11-19
1414 Neural knowledge assembly in humans and deep networks
Nelli, S. M.; Braun, L.; Dumbalska, T.; Saxe, A.; Summerfield, C.
10.1101/2021.10.21.465374 — neuroscience — Posted on 2021-11-19
1416 Susceptibility monitoring and the molecular characterization of resistance of Spodoptera frugiperda (Lepidoptera: Noctuidae) to lambda-cyhalothrin and chlorpyrifos
Nascimento, A. R. B. d.; Rodrigues, J. G.; Kanno, R. H.; Amaral, F. S. A.; Malaquias, J. B.; Silva-Brandao, K. L.; Consoli, F. L.; Omoto, C.
10.1101/2021.11.17.469006 — zoology — Posted on 2021-11-19
1417 Multiple trajectory alignment reconstructs disease dynamics for discovery and clinical benefit
Frishberg, A.; Milman, N.; Alpert, A.; Theis, F. J.; Schultze, J. L.; Shen-Orr, S. S.
10.1101/2021.11.17.468952 — systems biology — Posted on 2021-11-19
1418 A general model of the dynamics of genes with dual σ factor preference
Calado Baptista, I. S.; Kandavalli, V.; Chauhan, V.; Mohamed Bahrudeen, M. N.; Almeida, B. L. d. B.; Palma, C. S. D.; Dash, S.; Ribeiro, A.
10.1101/2021.11.17.468920 — systems biology — Posted on 2021-11-19
1419 Identification of antibiotic resistance proteins via MiCId's augmented workflow. A mass spectrometry-based proteomics approach
Alves, G.; Ogurtsov, A. Y.; Karlsson, R.; Jaen-Luchoro, D.; Pineiro-Iglesias, B.; Salva-Serra, F.; Andersson, B.; Moore, E.; Yu, Y.-K.
10.1101/2021.11.17.468978 — systems biology — Posted on 2021-11-19
1420 Automated assembly scaffolding elevates a new tomato system for high-throughput genome editing
Alonge, M.; Lebeigle, L.; Kirsche, M.; Aganezov, S.; Wang, X.; Lippman, Z. B.; Schatz, M. C.; Soyk, S.
10.1101/2021.11.18.469135 — plant biology — Posted on 2021-11-19
1422 Gene expression based inference of drug resistance in cancer
Chawla, S.; Rockstroh, A.; Lehman, M.; Rather, E.; Jain, A.; Anand, A.; Gupta, A.; Bhattacharya, N.; Poonia, S.; Rai, P.; Das, N.; Majumdar, A.; Jayadeva, J.; Ahuja, G.; Hollier, B. G.; Nelson, C. C.; Sengupta, D.
10.1101/2021.11.17.468905 — cancer biology — Posted on 2021-11-19
1423 The evolution of genomic, transcriptomic, and single-cell protein markers of metastatic upper tract urothelial carcinoma
Ohara, K.; Rendeiro, A. F.; Bhinder, B.; Eng, K. W.; Ravichandran, H.; Pisapia, D.; Vosoughi, A.; Fernandez, E.; Shohdy, K.; Manohar, J.; Beg, S.; Wilkes, D.; Robinson, B.; Khani, F.; Bareja, R.; Tagawa, S.; Sboner, A.; Elemento, O.; Faltas, B. M.; Mosquera, J. M.
10.1101/2021.11.16.468622 — cancer biology — Posted on 2021-11-19
1424 Characterizing disease-associated human proteins without available protein structures or homologues
Sen, N.; Anishchenko, I.; Bordin, N.; Sillitoe, I.; Velankar, S.; Baker, D.; Orengo, C.
10.1101/2021.11.17.468998 — bioinformatics — Posted on 2021-11-19
1425 A3D Database: Structure-based Protein Aggregation Predictions for the Human Proteome
Badaczewska-Dawid, A. E.; Garcia-Pardo, J.; Kuriata, A.; Pujols, J.; Ventura, S.; Kmiecik, S.
10.1101/2021.11.17.468872 — bioinformatics — Posted on 2021-11-19
1426 Source-sink connectivity: A novel interictal EEG marker for seizure localization
Gunnarsdottir, K. M.; Li, A.; Smith, R. J.; Kang, J.-Y.; Korzeniewska, A.; Crone, N.; Rouse, A. G.; Cheng, J. J.; Kinsman, M. J.; Landazuri, P.; Uysal, U.; Ulloa, C. M.; Cameron, N.; Cajigas, I.; Jagid, J. R.; Kanner, A.; Elarjani, T.; Bicchi, M. M.; Inati, S.; Zaghloul, K. A.; Boerwinkle, V.; Wyckoff, S.; Barot, N.; Gonzalez-Martinez, J.; Sarma, S. V.
10.1101/2021.10.15.464594 — bioengineering — Posted on 2021-11-19
1428 The natural adaptation and human selection history of African sheep genomes
Ahbara, A. M.; Robert, C.; Kebede, A.; Abebe, A.; Latairish, S.; Agoub, M. O.; Musa, H. H.; Wiener, P.; Clark, E.; Hanotte, O.; Mwacharo, J. M.
10.1101/2021.11.17.469022 — genomics — Posted on 2021-11-19
1430 Kinetic networks identify key regulatory nodes and transcription factor functions in early adipogenesis
Dutta, A. B.; Ngyuen, B.; Anderson, W. D.; Walavalkar, N. M.; Duarte, F. M.; Guertin, M. J.
10.1101/2021.11.17.469040 — genomics — Posted on 2021-11-19
1431 Trait Association and Prediction Through Integrative K-mer Analysis
He, C.; Washburn, J. D.; Hao, Y.; Zhang, Z.; Yang, J.; Liu, S.
10.1101/2021.11.17.468725 — genetics — Posted on 2021-11-19
1432 A new lineage of non-photosynthetic green algae with extreme organellar genomes
Panek, T.; Barcyte, D.; Treitli, S. C.; Zahonova, K.; Sokol, M.; Sevcikova, T.; Zadrobilkova, E.; Jaske, K.; Yubuki, N.; Cepicka, I.; Elias, M.
10.1101/2021.11.17.468966 — evolutionary biology — Posted on 2021-11-19
1436 Genetic and antigenic characterization of an expanding H3 influenza A virus clade in US swine visualized by Nextstrain
Neveau, M. N.; Zeller, M. A.; Kaplan, B. S.; Souza, C. K.; Gauger, P. C.; Vincent, A. L.; Anderson, T. K.
10.1101/2021.11.17.469008 — evolutionary biology — Posted on 2021-11-19
1437 Phylogenomic analyses using genomes and transcriptomes do not resolve relationships among major clades in Phrymaceae
Morales-Briones, D. F.; Lin, N.; Huang, E. Y.; Grossenbacher, D. L.; Sobel, J. M.; Gilmore, C. D.; Tank, D. C.; Yang, Y.
10.1101/2021.11.17.468996 — evolutionary biology — Posted on 2021-11-19
1440 The relationship between land cover and microbial community composition in European lakes
Sperlea, T.; Schenk, J. P.; Dressler, H.; Beisser, D.; Hattab, G.; Boenigk, J.; Heider, D.
10.1101/2021.11.17.468820 — ecology — Posted on 2021-11-19
1441 Edaphic controls on genome size and GC content of bacteria in soil microbial communities
Chuckran, P. F.; Flagg, C.; Propster, J.; Rutherford, W. A.; Sieradzki, E. T.; Blazewicz, S. J.; Hungate, B. A.; Pett-Ridge, J. A.; Schwartz, E.; Dijkstra, P.
10.1101/2021.11.17.469016 — ecology — Posted on 2021-11-19
1443 Siderophores as an iron source for Prochlorococcus in deep chlorophyll maximum layers of the oligotrophic ocean
Hogle, S. L.; Hackl, T.; Bundy, R. M.; Park, J.; Satinsky, B.; Hiltunen, T.; Biller, S.; Berube, P. M.; Chisholm, S. W.
10.1101/2021.11.13.468467 — ecology — Posted on 2021-11-19
1446 Robust temporal map of human in vitro myelopoiesis using single-cell genomics
Alsinet, C.; Primo, M.; Lorenzi, V.; Knights, A. J.; Sancho-Serra, C.; Park, J.-E.; Wyspianska, B. S.; Tough, D. F.; Alvarez, D.; Gaffney, D. J.; Vento-Tormo, R.
10.1101/2021.11.17.469005 — developmental biology — Posted on 2021-11-19
1447 Methylglyoxal Induces Endothelial Dysfunction via Stunning
Fleming, T.; Nettelbladt, B. v.; Morgenstern, J.; Campos, M.; La Marois, M.; Bartosova, M.; Hausser, I.; Schwab, C.; Fischer, A.; Nawroth, P. P.; Szendroedi, J.; Herzig, S.
10.1101/2021.11.18.469085 — cell biology — Posted on 2021-11-19
1448 LiveCellMiner: A New Tool to Analyze Mitotic Progression
Moreno-Andres, D.; Bhattacharyya, A.; Scheufen, A.; Stegmaier, J.
10.1101/2021.11.17.469067 — cell biology — Posted on 2021-11-19
1450 Human Cytomegalovirus modifies placental small extracellular vesicle secretion and composition towards a proviral phenotype to enhance infection of fetal recipient cells
Bergamelli, M.; Martin, H.; Aubert, Y.; Mansuy, J.-M.; Marcellin, M.; Burlet-Schiltz, O.; Hurbain, I.; Raposo, G.; Izopet, J.; Fournier, T.; Benchoua, A.; Benard, M.; Groussolles, M.; Cartron, G.; Tanguy le Gac, Y.; Moinard, N.; D'Angelo, G.; Malnou, C. E.
10.1101/2021.11.18.468660 — cell biology — Posted on 2021-11-19
1456 Kidney pathological changes alter cell clustering features in single-cell RNA sequencing
Ma, L.; Murea, M.; Choi, Y. A.; Hemal, A. K.; Mikhailov, A. V.; Snipes, J. A.; Chou, J. W.; Cui, W.; Miller, L. D.; Hawkins, G. A.; Palmer, N. D.; Langefeld, C. D.; Freedman, B. I.
10.1101/2021.10.08.463030 — cell biology — Posted on 2021-11-19
1457 Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
Cook, G. M.; Brown, K.; Shang, P.; Li, Y.; Soday, L.; Dinan, A. M.; Tumescheit, C.; Mockett, A. P. A.; Fang, Y.; Firth, A. E.; Brierley, I.
10.1101/2021.11.17.468997 — pathology — Posted on 2021-11-19
1458 Systems medicine dissection of chromosome 1q amplification reveals oncogenic regulatory circuits and informs targeted therapy in cancer
Trasanidis, N.; Katsarou, A.; Ponnusamy, K.; Shen, Y.-A.; Kostopoulos, I. V.; Bergonia, B.; Keren, K.; Reema, P.; Xiao, X.; Szydlo, R. M.; Sabbattini, P. M.; Roberts, I. A.; Auner, H. W.; Naresh, K. N.; Chaidos, A.; Wang, T.-L.; Magnani, L.; Caputo, V. S.; Karadimitris, A.
10.1101/2021.11.17.469031 — cancer biology — Posted on 2021-11-19
1460 A Thin-Film Lubrication Model for Biofilm Expansion Under Strong Adhesion
Tam, A. K. Y.; Harding, B.; Green, J. E. F.; Balasuriya, S.; Binder, B. J.
10.1101/2021.11.16.468738 — biophysics — Posted on 2021-11-19
1461 Adversarial domain translation networks enable fast and accurate large-scale atlas-level single-cell data integration
Zhao, J.; Wang, G.; Ming, J.; Lin, Z.; Wang, Y.; Tabula Microcebus Consortium, ; Wu, A. R.; Yang, C.
10.1101/2021.11.16.468892 — bioinformatics — Posted on 2021-11-19
1462 CRAFT: a bioinformatics software for custom prediction of circular RNA functions
Dal Molin, A.; Gaffo, E.; Difilippo, V.; Buratin, A.; Tretti Parenzan, C.; Bresolin, S.; Bortoluzzi, S.
10.1101/2021.11.17.468947 — bioinformatics — Posted on 2021-11-19
1463 Structural comparative modeling of multi-domain ΔF508 CFTR
McDonald, E. F.; Woods, H.; Smith, S.; Kim, M.; Schoeder, C. T.; Plate, L.; Meiler, J.
10.1101/2021.11.17.468921 — bioinformatics — Posted on 2021-11-19
1473 2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution
Vanderpoorten, O.; Babar, A. N.; Krainer, G.; Jacquat, R. P. B.; Challa, P. K.; Peter, Q.; Toprakcioglu, Z.; Xu, C. K.; Keyser, U. F.; Baumberg, J.; Kaminski, C. F.; Knowles, T. P. J.
10.1101/2021.11.17.468989 — biophysics — Posted on 2021-11-19
1474 Mapping morphological malformation to genetic dysfunction in blood vessel organoids with 22q11.2 Deletion Syndrome
He, S.; Xu, C.; Lao, Y.-H.; Chauhan, S.; Xiao, Y.; Willner, M. J.; Jin, Y.; McElroy, S.; Rao, S.; Gogos, J.; Tomer, R.; Azizi, E.; Xu, B.; Leong, K. W.
10.1101/2021.11.17.468969 — bioengineering — Posted on 2021-11-19
1475 Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls
Wilson, S. L.; Shen, S. Y.; Harmon, L. M.; Burgener, J. M.; Bratman, S. V.; Triche, T. J.; De Carvalho, D. D.; Hoffman, M. M.
10.1101/2021.02.12.430289 — genomics — Posted on 2021-11-19
1476 Evidence for a conserved queen-worker genetic toolkit across slave-making ants and their ant hosts
Feldmeyer, B.; Gstoettl, C.; Wallner, J.; Jongepier, E.; Seguret, A.; Grasso, A.; Bornberg-Bauer, E.; Foitzik, S.; Heinze, J.
10.1101/2021.10.20.465091 — evolutionary biology — Posted on 2021-11-19
1479 Maize AFP1 confers antifungal activity by inhibiting chitin deacetylases from a broad range of fungi
Ma, L.-S.; Tsai, W.-L.; Kalunke, R. M.; Xu, M.-Y.; Lin, Y.-H.; Damei, F. A.; Lee, H.-C.
10.1101/2021.11.02.466889 — microbiology — Posted on 2021-11-19
1480 Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases
Roostaei, T.; Diaconu, C.; Touil, H.; Harbison, C.; Zhang, Y.; Epstein, S.; Tuddenham, J.; Thakur, K.; Bryois, J.; Wiendl, H.; Meyer zu Hörste, G.; Malhotra, D.; Riley, C.; Menon, V.; De Jager, P. L.
10.1101/2021.11.01.466797 — immunology — Posted on 2021-11-19
1482 Lonely in the dark: trauma memory and sex-specific dysregulation of amygdala reactivity to fear signals
Morr, M.; Noell, J.; Sassin, D.; Daniels, J.; Philipsen, A.; Becker, B.; Stoffel-Wagner, B.; Hurlemann, R.; Scheele, D.
10.1101/2021.11.16.468598 — neuroscience — Posted on 2021-11-19
1483 Comparison of seven modelling algorithms for GABA-edited 1H-MRS
Craven, A. R.; Bhattacharyya, P. K.; Clarke, W. T.; Dydak, U.; Edden, R. A. E.; Ersland, L.; Mandal, P. K.; Mikkelsen, M.; Murdoch, J. B.; Near, J.; Rideaux, R.; Shukla, D.; Wang, M.; Wilson, M.; Zöllner, H.; Hugdahl, K.; Oeltzschner, G.
10.1101/2021.11.15.468534 — neuroscience — Posted on 2021-11-19
1486 The sleep EEG envelope: a novel, neuronal firing-based human biomarker
Ujma, P. P.; Dresler, M.; Simor, P.; Fabo, D.; Ulbert, I.; Eross, L.; Bodizs, R.
10.1101/2021.11.16.468788 — neuroscience — Posted on 2021-11-19
1487 Mitochondrial OPA1 deficiency causes reversible defects in adult neurogenesis-associated spatial memory in mice
Andraini, T.; Mouledous, L.; Petsophonsakul, P.; Florian, C.; Lopez, S.; Daloyau-Botella, M.; Arrazola, M.; Nikolla, K.; Philip, A.; Leydier, A.; Marque, M.; Arnaune-Pelloquin, L.; Belenguer, P.; Rampon, C.; Miquel, M.-C.
10.1101/2021.11.16.468792 — neuroscience — Posted on 2021-11-19
1488 Exploratory methods for high-performance EEG speech decoding
Comstock, L. B.; Lainscsek, C.; Carvalho, V. R.; Mendes, E.; Fallah, A.; Sejnowski, T. J.
10.1101/2021.11.16.468876 — neuroscience — Posted on 2021-11-19
1492 Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
Thorpe, H. A.; Tourrette, E.; Yahara, K.; Vale, F. F.; Liu, S.; Oleastro, M.; Alarcon, T.; Perets, T.; Latifi-Navid, S.; Yamaoka, Y.; Martinez-Gonzalez, B.; Karayiannis, I.; Karamitros, T.; Sgouras, D.; Elamin, W.; Pascoe, B.; Sheppard, S.; Ronkainen, J.; Aro, P.; Engstrand, L.; Agreus, L.; Suerbaum, S.; Thorell, K.; Falush, D.
10.1101/2021.06.05.447065 — evolutionary biology — Posted on 2021-11-19
1494 Validation of cervical lesion proportion measure using a gridded imaging techique to assess cervical pathology in women with genital schistosomiasis
Leutcher, P.; Aaroe, K.; Arenholt, L.; Norderud, K.; Lumholdt, M.; Randrianasolo, B.; Ramarokoto, C. E.; Rabozakandraina, o.; Bronnum, D.; Feldmeier, H.
10.1101/2021.11.16.468781 — pathology — Posted on 2021-11-19
1497 Weighing the DNA content of Adeno-Associated Virus vectors with zeptogram precision using nanomechanical resonators
Katsikis, G.; Hwang, I. E.; Wang, W.; Bhat, V. S.; McIntosh, N. L.; Karim, O. A.; Blus, B. J.; Sha, S.; Agache, V.; Wolfrum, J. M.; Springs, S. L.; Sinskey, A. J.; Barone, P. W.; Braatz, R. D.; Manalis, S. R.
10.1101/2021.11.15.468734 — bioengineering — Posted on 2021-11-19
1498 Whole genome sequencing uncovers the structural and transcriptomic landscape of hexaploid wheat/Am. muticum introgression lines
Coombes, B.; Fellers, J. P.; Grewal, S.; Rusholme-Pilcher, R.; Hubbart-Edwards, S.; Yang, C.-Y.; Joynson, R.; King, I. P.; King, J.; Hall, A.
10.1101/2021.11.16.468825 — genomics — Posted on 2021-11-19
1499 Repeated translocation of a supergene underlying rapid sex chromosome turnover in Takifugu fish
Kabir, A.; Ieda, R.; Hosoya, S.; Fujikawa, D.; Atsumi, K.; Tajima, S.; Nozawa, A.; Koyama, T.; Hirase, S.; Nakamura, O.; Kadota, M.; Nishimura, O.; Kuraku, S.; Nakamura, Y.; Kobayashi, H.; Toyoda, A.; Tasumi, S.; Kikuchi, K.
10.1101/2021.11.16.468883 — genomics — Posted on 2021-11-19
1500 Tissue-specific impacts of aging and genetics on gene expression patterns in humans
Yamamoto, R.; Chung, R.; Vazquez, J. M.; Sheng, H.; Steinberg, P.; Ioannidis, N.; Sudmant, P. H.
10.1101/2021.11.16.468753 — genetics — Posted on 2021-11-19
1501 Evidence of stock connectivity, hybridization and misidentification in white anglerfish support the need for adopting a genetics-informed fisheries management approach
Aguirre-Sarabia, I.; Diaz-Arce, N.; Pereda-Agirre, I.; Mendibil, I.; Urtizberea, A.; Gerritsen, H. D.; Burns, F.; Holmes, I.; Landa, J.; Coscia, I.; Quincoces, I.; Santurtun, M.; Zanzi, A.; Martinsohn, J. T.; Rodriguez-Ezpeleta, N.
10.1101/2021.02.10.430581 — evolutionary biology — Posted on 2021-11-19
1502 Spatial scale of transmission explains how acute infections circulate at low prevalence
Mancy, R.; Rajeev, M.; Lugelo, A.; Brunker, K.; Cleaveland, S.; Ferguson, E. A.; Hotopp, K.; Kazwala, R.; Magoto, M.; Rysava, K.; Haydon, D. T.; Hampson, K.
10.1101/2021.11.16.468880 — ecology — Posted on 2021-11-19
1504 Glacier-fed stream biofilms harbour diverse resistomes and biosynthetic gene clusters
Busi, S. B.; de Nies, L.; Pramateftaki, P.; Bourquin, M.; Kohler, T. J.; Ezzat, L.; Fodelianakis, S.; Peter, H.; Michoud, G.; Styllas, M.; Tolosano, M.; de Staercke, V.; Schon, M.; Galata, V.; Wilmes, P.; Battin, T.
10.1101/2021.11.18.469141 — microbiology — Posted on 2021-11-19
1505 Whole transcriptome-sequencing and network analysis of CD1c+ human dendritic cells identifies cytokine-secreting subsets linked to type I IFN-negative autoimmunity to the eye
Hiddingh, S.; Pandit, A.; Verhagen, F.; Rijken, R.; Servaas, N.; Komer-Wichers, R.; Dam-van Loon, N. t.; Imhof, S. S.; Radstake, T.; de Boer, J. H.; Kuiper, J. J. W.
10.1101/2021.11.16.468816 — immunology — Posted on 2021-11-19
1514 Aerobic glycolysis in cancer cells supplies ATP while preventing excess metabolic thermogenesis
Okahashi, N.; Shima, T.; Kondo, Y.; Araki, C.; Tsuji, S.; Sawai, A.; Uehara, H.; Kohno, S.; Shimizu, H.; Takahashi, C.; Matsuda, F.
10.1101/2021.11.16.468557 — cancer biology — Posted on 2021-11-19
1518 Extending and using anatomical vocabularies in the Stimulating Peripheral Activity to Relieve Conditions (SPARC) project
Surles-Zeigler, M. C.; Sincomb, T.; Gillespie, T. H.; de Bono, B.; Bresnahan, J.; Mawe, G. M.; Grethe, J. S.; Tappan, S.; Heal, M.; Martone, M. E.
10.1101/2021.11.15.467961 — bioinformatics — Posted on 2021-11-19
1519 Marker-free characterization of single live circulating tumor cell full-length transcriptomes
Poonia, S.; Goel, A.; Chawla, S.; Bhattacharya, N.; Rai, P.; Lee, Y. F.; Yap, Y. S.; West, J.; Bhagat, A. A.; Juhi Tayal, J.; Mehta, A.; Ahuja, G.; Majumdar, A.; Ramalingam, N.; Sengupta, D.
10.1101/2021.11.16.468747 — bioinformatics — Posted on 2021-11-19
1520 FastQTLmapping: an ultra-fast package for mQTL-like analysis
Gao, X.; Li, J.; Liu, X.; Peng, Q.; Jing, H.; Wang, S.; Liu, F.
10.1101/2021.11.16.468610 — bioinformatics — Posted on 2021-11-19
1522 SC2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data
Feng, J.; Goedegebuure, S. P.; Zeng, A.; Bi, Y.; Wang, T.; Payne, P. R.; Ding, L.; DeNardo, D.; Hawkins, W.; Fields, R. C.; Li, F.
10.1101/2021.11.15.468755 — bioinformatics — Posted on 2021-11-19
1523 WebSeq: A Genomic Data Analytics Platform for Monogenic Disease Discovery
Agarwal, M.; Ghimire, K.; Cogan, J. D.; Undiagnosed Disease Network, ; Markle, J.
10.1101/2021.11.16.460500 — bioinformatics — Posted on 2021-11-19
1524 Hierarchical organization of rhesus macaque behavior
Voloh, B.; Eisenreich, B. R.; Maisson, D. J.; Ebitz, R. B.; Park, H. S.; Hayden, B. Y.; Zimmermann, J.
10.1101/2021.11.15.468721 — animal behavior and cognition — Posted on 2021-11-19
1526 The haplotype-resolved chromosome pairs and transcriptome of a heterozygous diploid African cassava cultivar
Qi, W.; Lim, Y.-W.; Patrignani, A.; Schlaepfer, P.; Bratus-Neuenschwander, A.; Grueter, S.; Chanez, C.; Rodde, N.; Prat, E.; Vautrin, S.; Fustier, M.-A.; Pratas, D.; Schlapbach, R.; Gruissem, W.
10.1101/2021.11.16.468774 — genomics — Posted on 2021-11-19
1527 Disentangling signatures of selection before and after European colonization in Latin Americans
Mendoza-Revilla, J.; Chacon-Duque, C.; Fuentes-Guajardo, M.; Ormond, L.; Wang, K.; Hurtado, M.; Villegas, V.; Granja, V.; Acuna-Alonzo, V.; Jaramillo, C.; Barquera Lozano, R.; Gomez-Valdes, J.; Villamil-Ramirez, H.; Silva de Cerqueira, C. C.; Badillo Rivera, K. M.; Nieves-Colon, M. A.; Gignoux, C. R.; Wojcik, G. L.; Moreno-Estrada, A.; Hunemeier, T.; Ramallo, V.; Schuler-Faccini, L.; Gonzalez-Jose, R.; Catira Bortolini, M.; Canizales-Quinteros, S.; Gallo, C.; Poletti, G.; Bedoya, G.; Rothhammer, F.; Balding, D.; Fumagalli, M.; Adhikari, K.; Ruiz-Linares, A.; Hellenthal, G.
10.1101/2021.11.15.467418 — genomics — Posted on 2021-11-19
1528 cSurvival: a web resource for biomarker interactions in cancer outcomes
Cheng, X.; Liu, Y.; Wang, J.; Chen, Y.; Robertson, A. G.; Zhang, X.; Jones, S.; Taubert, S.
10.1101/2021.11.15.468756 — genomics — Posted on 2021-11-19
1534 The landscape of metabolic brain alterations in Alzheimer's disease
Batra, R.; Arnold, M.; Woerheide, M.; Allen, M.; Wang, X.; Blach, C.; Levey, A. I.; Seyfried, N.; Ertekin-Taner, N.; Bennett, D. A.; Kastenmüller, G.; Kaddurah-Daouk, R.; Krumsiek, J.
10.1101/2021.11.15.468698 — neuroscience — Posted on 2021-11-19
1536 Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
Simola, J.; Siebenhühner, F.; Myrov, V.; Kantojärvi, K.; Paunio, T.; Palva, J. M.; Brattico, E.; Palva, S.
10.1101/2021.11.16.468778 — neuroscience — Posted on 2021-11-19
1538 Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
Kaiser, M. S.; Milan, G.; Lin, S.; Oliveri, F.; Chojnowska, K.; Tintignac, L. A.; Mittal, N.; Zimmerli, C. E.; Glass, D. J.; Zavolan, M.; Ham, D. J.; Ruegg, M. A.
10.1101/2021.11.16.468773 — physiology — Posted on 2021-11-19
1539 NAD precursors cycle between host tissues and the gut microbiome
Chellappa, K.; McReynolds, M. R.; Lu, W.; Zeng, X.; Makarov, M.; Hayat, F.; Mukherjee, S.; Bhat, Y. R.; Lingala, S. R.; Shima, R. T.; Descamps, H. C.; Cox, T.; Ji, L.; Jankowski, C.; Chu, Q.; Davidson, S. M.; Thaiss, C. A.; Migaud, M. E.; Rabinowitz, J. D.; Baur, J. A.
10.1101/2021.11.15.468729 — physiology — Posted on 2021-11-19
1541 Localized delivery of β-NGF via injectable microrods accelerates endochondral fracture repair
Rivera, K. O.; Cuylear, D. L.; Duke, V.; O'Hara, K. M.; Kharbikar, B. N.; Kryger, A. N.; Miclau, T.; Bahney, C. S.; Desai, T. A.
10.1101/2021.11.16.468864 — bioengineering — Posted on 2021-11-19
1542 Transcription Factor Gene Pea3 Regulates Erectile Function in Mice
Weinrich, J. A.; Tyagi, A.; DiCasoli, R.; Kenney, M. C.; Kaltschmidt, J. A.
10.1101/2021.11.15.468751 — animal behavior and cognition — Posted on 2021-11-19
1546 The critical role of the ventral temporal lobe in word retrieval
Snyder, K. M.; Forseth, K. J.; Donos, C.; Rollo, P. S.; Fischer-Baum, S.; Breier, J.; Tandon, N.
10.1101/2021.11.18.469030 — neuroscience — Posted on 2021-11-19
1553 Advancing motion denoising of multiband resting state functional connectivity fMRI data
Williams, J. C.; Tubiolo, P. N.; Luceno, J. R.; Van Snellenberg, J. X.
10.1101/860635 — neuroscience — Posted on 2021-11-18
1554 Mechanics of cell integration in vivo
Ventura, G. B.; Amiri, A.; Thiagarajan, R.; Tolonen, M.; Doostmohammadi, A.; Sedzinski, J.
10.1101/2021.11.18.469090 — biophysics — Posted on 2021-11-18
1555 Structural basis for Cas9 off-target activity
Pacesa, M.; Lin, C.-H.; Clery, A.; Bargsten, K.; Irby, M. J.; Allain, F. H.; Cameron, P.; Donohoue, P. D.; Jinek, M.
10.1101/2021.11.18.469088 — biochemistry — Posted on 2021-11-18
1556 Genetic relationships between efficiency traits and gut microbiota traits in growing pigs fed a conventional or a high fiber diet
Deru, V.; Bouquet, A.; Zemb, O.; Blanchet, B.; De Almeida, M.-L.; Cauquil, L.; Carillier-Jacquin, C.; Gilbert, H.
10.1101/2021.11.15.468583 — genetics — Posted on 2021-11-18
1559 Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodelling by Hfq master regulator
Cossa, A.; Trepout, S.; Wien, F.; Le Brun, E.; Turbant, F.; Pereiro, E.; Arluison, V.
10.1101/2021.11.18.469145 — microbiology — Posted on 2021-11-18
1560 Learning from unexpected events in the neocortical microcircuit
Gillon, C. J.; Pina, J. E.; Lecoq, J.; Ahmed, R.; Billeh, Y. N.; Caldejon, S.; Groblewski, P.; Henley, T. M.; Kato, I.; Lee, E.; Luviano, J.; Mace, K.; Nayan, C.; Nguyen, T. V.; North, K.; Perkins, J.; Seid, S.; Valley, M. T.; Williford, A.; Bengio, Y.; Lillicrap, T. P.; Richards, B. A.; Zylberberg, J.
10.1101/2021.01.15.426915 — neuroscience — Posted on 2021-11-18
1562 Activating silent glycolysis bypasses in Escherichia coli
Iacometti, C.; Marx, K.; Hoenick, M.; Biletskaia, V.; Schulz-Mirbach, H.; Satanowski, A.; Dronsella, B.; Bouzon, M.; Doering, V.; Dubois, I.; Berger, A.; Delmas, V. A.; Noor, E.; Bar-Even, A.; Lindner, S. N.
10.1101/2021.11.18.468982 — synthetic biology — Posted on 2021-11-18
1563 MAPR origins reveal a new class of prokaryotic cytochrome b5 proteins and possible role in eukaryogenesis
Tamarit, D.; Teakel, S.; Marama, M.; Aragao, D.; Gerdes, S. Y.; Forwood, J. K.; Ettema, T. J. G.; Cahill, M. A.
10.1101/2021.11.17.468889 — evolutionary biology — Posted on 2021-11-18
1566 Omics profiling identifies MAPK/ERK pathway as a gatekeeper of nephron progenitor metabolism
Kwon, H. N.; Kurtzeborn, K.; Jin, X.; Loh, A.; Escande-Beillard, N.; Reversade, B.; Park, S.; Kuure, S.
10.1101/2021.09.27.461969 — developmental biology — Posted on 2021-11-18
1567 53BP1 mediated recruitment of RASSF1A at ribosomal DNA breaks facilitates local ATM signal amplification
Tsaridou, S.; Velimezi, G.; Willenbrock, F.; Chatzifrangkeskou, M.; Panagopoulos, A.; Karamitros, D.; Gorgoulis, V. G.; Lygerou, Z.; O'Neill, E.; Pefani, D.-E.
10.1101/2021.11.17.469058 — cell biology — Posted on 2021-11-18
1569 Reversible bacteriophage resistance by shedding the bacterial cell wall
Ongenae, V.; Mabrouk, A. S.; Crooijmans, M.; Rozen, D.; Briegel, A.; Claessen, D.
10.1101/2021.11.17.468999 — microbiology — Posted on 2021-11-18
1570 Evasion of Toll-like Receptor Recognition by Escherichia coli is mediated via Population Level Regulation of Flagellin Production
Lanz, M.; Birchall, C. M.; Drage, L. K.; Picton, D. M.; Mowbray, C.; Alsenani, Q.; Tan, A. M. Z.; Ali, A.; Harding, C.; Pickard, R.; Hall, J.; Aldridge, P. D.
10.1101/2021.11.18.469103 — microbiology — Posted on 2021-11-18
1571 Glacier-fed stream biofilms harbour diverse resistomes and biosynthetic gene clusters
Busi, S. B.; de Nies, L.; Pramateftaki, P.; Bourquin, M.; Kohler, T. J.; Ezzat, L.; Fodelianakis, S.; Peter, H.; Michoud, G.; Styllas, M.; Tolosano, M.; de Staercke, V.; Schon, M.; Galata, V.; Battin, T.; Wilmes, P.
10.1101/2021.11.18.469141 — microbiology — Posted on 2021-11-18
1572 Aging and interferon gamma response drive the phenotype of neutrophils in the inflamed joint
Grieshaber-Bouyer, R.; Exner, T.; Hackert, N. S.; Radtke, F. A.; Jelinsky, S. A.; Halyabar, O.; Wactor, A.; Karimizadeh, E.; Schettini, J.; Jonsson, A. H.; Rao, D. A.; Henderson, L. A.; Mueller-Tidow, C.; Lorenz, H.-M.; Wabnitz, G.; Lederer, J. A.; Hadjipanayis, A.; Nigrovic, P. A.
10.1101/2021.11.16.465905 — immunology — Posted on 2021-11-18
1574 Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes
Radulescu, A.; Todd, G.; Williams, C.; Bennink, B. A.; Lemus, A.; Chesbro, H.; Bourgeois, J. R.; Kopec, A. M.; Zuloaga, D. G.; Scimemi, A.
10.1101/2021.05.08.443234 — neuroscience — Posted on 2021-11-18
1579 Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension
Aifuwa, I.; Phillip, J. M.; Kim, B.; Luperchio, T.; Jimenez, A.; Perestrelo, T.; Lee, S.-H.; Longe, N.; Reddy, K.; Ha, T.; Wirtz, D.
10.1101/2021.11.17.468902 — cancer biology — Posted on 2021-11-18
1580 Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL
Bruch, P.-M.; Giles, H. A. R.; Kolb, C.; Herbst, S. A.; Becirovic, T.; Roider, T.; Lu, J.; Scheinost, S.; Wagner, L.; Huellein, J.; Berest, I.; Kriegsmann, M.; Kriegsmann, K.; Zgorzelski, C.; Dreger, P.; Zaugg, J. B.; Müller-Tidow, C.; Zenz, T.; Huber, W.; Dietrich, S.
10.1101/2021.07.23.453514 — cancer biology — Posted on 2021-11-18
1585 Genome and transcriptome architecture of allopolyploid okra (Abelmoschus esculentus)
Nieuwenhuis, R.; Hesselinkk, T.; van den Broeck, H. C.; Cordewener, J.; Schijlen, E.; Bakker, L.; Diaz Trivino, S.; Struss, D.; de Hoop, S.-J.; de Jong, H.; Peters, S. A.
10.1101/2021.11.18.469076 — genomics — Posted on 2021-11-18
1589 A novel enhancer that regulates Bdnf expression in developing neurons
Brookes, E.; Au, H. Y. A.; Varsally, W.; Barrington, C.; Hadjur, S.; Riccio, A.
10.1101/2021.11.18.469096 — molecular biology — Posted on 2021-11-18
1590 TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in Glioblastoma multiforme
Admoni-Elisha, L.; Feldman, M.; Elbaz, T.; Chopra, A.; Shapira, G.; Fry, C. J.; Shomron, N.; Biggar, K.; Levy, D.
10.1101/2021.11.18.469142 — molecular biology — Posted on 2021-11-18
1591 Epoxidized graphene grid for high-throughput high-resolution cryoEM structural analysis
Fujita, J.; Makino, F.; Asahara, H.; Moriguchi, M.; Kumano, S.; Anzai, I.; Kishikawa, J.-i.; Matsuura, Y.; Kato, T.; Namba, K.; Inoue, T.
10.1101/2021.11.17.468963 — molecular biology — Posted on 2021-11-18
1599 HSP70-driven molecular response to the proteasome machinery inhibition is a vulnerability in cancer
Oron, M.; Grochowski, M.; Jaiswar, A.; Nowak-Niezgoda, M.; Kolos, M.; Kazmierczak, W.; Olesinski, T.; Lenarcik, M.; Cybulska, M.; Mikula, M.; Zylicz, A.; Zettl, K.; Wisniewski, J. R.; Walerych, D.
10.1101/2021.11.16.468807 — cancer biology — Posted on 2021-11-18
1602 Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
Zeng, Y. A.; Wang, J.; He, L.; Xie, Z.; Yu, W.; Lu, Y.; Wang, Z.; Bai, L.; Liu, C.; Fu, J.; Zhang, L.
10.1101/2021.11.17.468967 — developmental biology — Posted on 2021-11-18
1607 Interdependence between histone marks and steps in Pol II transcription
Wang, Z.; Chivu, A. G.; Choate, L. A.; Rice, E. J.; Miller, D. C.; Chu, T.; Chou, S.-P.; Kingsley, N. B.; Peterson, J. L.; Finno, C. J.; Bellone, R. R.; Antczak, D. F.; Lis, J.; Danko, C. G.
10.1101/2020.04.08.032730 — genomics — Posted on 2021-11-18
1609 PLB-985 neutrophil-like cells as a model to study Aspergillus fumigatus pathogenesis
Rafiq, M.; Rivieccio, F.; Zimmermann, A.-K.; Visser, C.; Bruch, A.; Krüger, T.; Gonzalez Rojas, K.; Kniemeyer, O.; Blango, M. G.; Brakhage, A. A.
10.1101/2021.07.28.454178 — microbiology — Posted on 2021-11-18
1611 Swine H1N1 influenza virus variants with enhanced polymerase activity and HA stability promote airborne transmission in ferrets
Hu, M.; Jones, J.; Banoth, B.; Ojha, C. R.; Crumpton, J. C.; Kercher, L.; Webster, R. G.; Webby, R. J.; Russell, C. J.
10.1101/2021.09.22.461336 — microbiology — Posted on 2021-11-18
1612 De novo designed transmembrane domains tune engineered receptor functions
Elazar, A.; Chandler, N. J.; Davey, A. S.; Weinstein, J. Y.; Nguyen, J. V.; Trenker, R.; Cross, R. R.; Jenkins, M. R.; Call, M. J.; Call, M. E.; Fleishman, S. J.
10.1101/2020.07.26.221598 — synthetic biology — Posted on 2021-11-18
1618 Impact of pre-anthesis drought stress on physiology, yield-related traits and drought responsive genes in green super rice
Ahmad, H.; Zafar, S. A.; Naeem, M. K.; Shokat, S.; Inam, S.; Naveed, A. S.; Xu, J.; Li, Z.; Ali, G. M.; Khan, M. R.
10.1101/2021.11.18.469071 — plant biology — Posted on 2021-11-18
1623 Fluorescence lifetime imaging of pH along the secretory pathway
Linders, P.; Ioannidis, M.; ter Beest, M.; van den Bogaart, G.
10.1101/2021.03.29.437519 — cell biology — Posted on 2021-11-18
1628 A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
Lacoste, J.; Soula, H.; Burg, A.; Audibert, A.; Darnat, P.; Gho, M.; Louvet-Vallee, S.
10.1101/2021.03.10.434802 — developmental biology — Posted on 2021-11-18
1631 Individual differences in frontoparietal plasticity in humans
Boroshok, A. L.; Park, A. T.; Fotiadis, P.; Velasquez, G. H.; Tooley, U. A.; Simon, K. R.; Forde, J. C. P.; Delgado Reyes, L. M.; Tisdall, M. D.; Bassett, D. S.; Cooper, E. A.; Mackey, A. P.
10.1101/2021.11.08.467831 — neuroscience — Posted on 2021-11-18
1632 Reconstitution of 3'-processing of mammalian pre-mRNA reveals a central role of RBBP6
Schmidt, M.; Kluge, F.; Sandmeir, F.; Kühn, U.; Schäfer, P.; Tüting, C.; Ihling, C.; Conti, E.; Wahle, E.
10.1101/2021.11.02.466878 — biochemistry — Posted on 2021-11-18
1635 Persistence of Plasmodium cynomolgi hypnozoites in cynomolgus monkey iPS-derived hepatocytes
Pellisson, M.; Zeeman, A.-M.; Doll, T.; Kirchhofer-Allan, L.; Schuierer, S.; Roma, G.; Flannery, E. L.; Mikolajczak, S. A.; Kocken, C. H. M.; Maeser, P.; Rottmann, M.; Mueller, M.
10.1101/2021.11.16.468833 — cell biology — Posted on 2021-11-18
1636 Binocular Mirror-Symmetric Microsaccadic Sampling Enables Drosophila Hyperacute 3D-Vision
Kemppainen, J.; Scales, B.; Razban Haghighi, K.; Takalo, J.; Mansour, N.; McManus, J.; Leko, G.; Saari, P.; Hurcomb, J.; Antohi, A.; Suuronen, J.-P.; Blanchard, F.; Hardie, R. C.; Song, Z.; Hampton, M.; Eckermann, M.; Westermeier, F.; Frohn, J.; Hoekstra, H.; Lee, C.-H.; Huttula, M.; Mokso, R.; Juusola, M.
10.1101/2021.05.03.442473 — neuroscience — Posted on 2021-11-18
1637 Using OPM-MEG in contrasting magnetic environments
Hill, R. M.; Devasagayam, J.; Holmes, N.; Boto, E.; Shah, V.; Osborne, J.; Safar, K.; Worcester, F.; Mariani, C.; Dawson, E.; Woolger, D.; Bowtell, R.; Taylor, M.; Brookes, M. J.
10.1101/2021.11.15.468615 — neuroscience — Posted on 2021-11-18
1638 Muscle activation strategies of the vastus lateralis according to sex
Guo, Y.; Jones, E. J.; Inns, T. B.; Ely, I. A.; Stashuk, D. W.; Wilkinson, D. J.; Smith, K.; Piasecki, J.; Phillips, B. E.; Atherton, P. J.; Piasecki, M.
10.1101/2021.11.01.466761 — physiology — Posted on 2021-11-18
1641 Cephalopod Retinal Development Shows Vertebrate-like Mechanisms of Neurogenesis
Napoli, F. R.; Daly, C. M.; Neal, S.; McCulloch, K. J.; Zaloga, A.; Liu, A.; Koenig, K. M.
10.1101/2021.10.28.466353 — developmental biology — Posted on 2021-11-18
1642 Cryobanking of human distal lung epithelial cells for preservation of their phenotypic and functional characteristics.
Konda, B.; Mulay, A.; Yao, C.; Israely, E.; Beil, S.; Huynh, C. A.; Tourtellotte, W. G.; Rampolla, R.; Chen, P.; Carraro, G.; Stripp, B. R.
10.1101/2021.11.15.468402 — cell biology — Posted on 2021-11-18
1644 FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
Ishiguro, K.-i.; Nobuhiro, T.; Takemoto, K.; Horisawa-Takada, Y.; Shimada, R.; Sayoko, F.; Tani, N.; Takeda, N.; Araki, K.
10.1101/2021.11.17.469052 — cell biology — Posted on 2021-11-18
1645 Angiogenesis is critical for the regenerative effects of exercise.
Wariyar, S. S.; Brown, A. D.; Tian, T.; Pottorf, T. S.; Ward, P. J.
10.1101/2021.11.17.468965 — cell biology — Posted on 2021-11-18
1647 In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Imanishi, S.; Huang, L.; Itakura, S.; Ishizaka, M.; Iwasaki, Y.; Yamaguchi, T.; Miyamoto-Sato, E.
10.1101/2021.04.23.441075 — molecular biology — Posted on 2021-11-18
1648 Brain state and cortical layer-specific mechanisms underlying perception at threshold
Morton, M. P.; Denagamage, S.; Blume, I. J.; Reynolds, J. H.; Jadi, M. P.; Nandy, A. S.
10.1101/2021.11.16.468866 — neuroscience — Posted on 2021-11-18
1651 Complementary population codes in the dorsal and ventral hippocampus during associative learning
Biane, J. S.; Ladow, M. A.; Stefanini, F.; Boddu, S. P.; Fan, A.; Hassan, S.; Dundar, N.; Apodaca-Montano, D. L.; Woods, N. I.; Khierbek, M. A.
10.1101/2021.11.16.468862 — neuroscience — Posted on 2021-11-18
1652 The natural frequencies of the resting human brain: an MEG-based atlas
Capilla, A.; Arana, L.; Garcia-Huescar, M.; Melcon, M.; Gross, J.; Campo, P.
10.1101/2021.11.17.468973 — neuroscience — Posted on 2021-11-18
1653 Anticipatory dynamics in the human brain guide foraging for primary rewards
Shintaki, R.; Tanaka, D.; Suzuki, S.; Yoshimoto, T.; Sadato, N.; Chikazoe, J.; Jimura, K.
10.1101/2021.11.16.468916 — neuroscience — Posted on 2021-11-18
1654 Neural Mechanisms of Learning are Critically Dependent on Sleep
Guttesen, A. a. V.; Gaskell, M. G.; Madden, E. V.; Appleby, G.; Cross, Z. R.; Cairney, S. A.
10.1101/2021.11.16.468870 — neuroscience — Posted on 2021-11-18
1658 Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance
Buil, J. B.; Oliver, J. D.; Law, D.; Baltussen, T. J. H.; Zoll, J.; Hokken, M.; Tehupeiory-Kooreman, M. C.; Melchers, W. J. G.; Birch, M.; Verweij, P. E.
10.1101/2021.11.16.468917 — microbiology — Posted on 2021-11-17
1659 High-Throughput Translational Profiling with riboPLATE-seq
Metz, J. B.; Hornstein, N. J.; Das Sharma, S.; Worley, J.; Gonzalez, C.; Sims, P. A.
10.1101/819094 — systems biology — Posted on 2021-11-17
1660 Orthogonal control of gene expression in plants using synthetic promoters and CRISPR-based transcription factors
Kar, S.; Bordiya, Y.; Rodriguez, N.; Kim, J.; Gardner, E. C.; Gollihar, J.; Sung, S.; Ellington, A. D.
10.1101/2021.11.16.468903 — synthetic biology — Posted on 2021-11-17
1663 Getting close to nature - Plasmodium knowlesi reference genome sequences from contemporary clinical isolates
Oresegun, D. R.; Thorpe, P.; Benavente, E. D.; Campino, S.; Fauzi, M.; Moon, R.; Clark, T. G.; Cox-Singh, J.
10.1101/2021.11.16.468780 — genomics — Posted on 2021-11-17
1666 IFITM dependency of SARS-CoV-2 variants of concern
Nchioua, R.; Schundner, A.; Kmiec, D.; Prelli Bozzo, C.; Zech, F.; Koepke, L.; Frick, M.; Sparrer, K. M.; Kirchhoff, F.
10.1101/2021.11.17.468942 — microbiology — Posted on 2021-11-17
1671 Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy
Comba, A.; Faisal, S. M.; Dunn, P. J.; Argento, A. E.; Hollon, T. C.; Al-Holou, W.; Varela, M. L.; Zamler, D. B.; Quass, G. L.; Apostolides, P. F.; Brown, C. E.; Kish, P. E.; Kahana, A.; Kleer, C. G.; Motsch, S.; Castro, M. G.; Lowenstein, P. R.
10.1101/2020.12.01.404970 — cancer biology — Posted on 2021-11-17
1672 The mouse mammary tumor virus intasome exhibits distinct dynamics on target DNA
Baltierra-Jasso, L. E.; Jones, N. D.; Ballandras-Collas, A.; Engelman, A.; Fishel, R.; Yoder, K. E.
10.1101/2021.11.17.468995 — biochemistry — Posted on 2021-11-17
1673 Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency
Jung, Y.-E.; Lee, K. W.; Cho, J. H.; Bae, D.-W.; Jeong, B.-G.; Jung, Y.-J.; An, Y. J.; Kim, K.; Lee, G. S.; Kang, L.-W.; Moon, J. H.; Lee, J.-H.; Kim, E.-K.; Yim, H.-S.; Cha, S.-S.
10.1101/2021.11.16.468794 — biochemistry — Posted on 2021-11-17
1674 NUDT18 catalyzes hydrolysis of active metabolites of the antivirals Remdesivir and Ribavirin
Jemth, A.-S.; Scaletti, E. R.; Homan, E. J.; Stenmark, P.; Helleday, T.; Michel, M.
10.1101/2021.11.16.468802 — biochemistry — Posted on 2021-11-17
1675 DNA Breaks and Gaps Target Retroviral Integration
Senavirathne, G.; Gardner, A.; London, J.; Messer, R. K.; Tan, Y.-Y.; Yoder, K. E.; Fishel, R.
10.1101/2021.11.17.469012 — biochemistry — Posted on 2021-11-17
1676 The evolution of widespread recombination suppression on the Dwarf Hamster (Phodopus) X chromosome
Moore, E. C.; Thomas, G. W. C.; Mortimer, S.; Kopania, E. E. K.; Hunnicutt, K. E.; Clare-Salzler, Z. J.; Larson, E. E.; Good, J. M.
10.1101/2021.11.15.468705 — genomics — Posted on 2021-11-17
1677 Global Mutational Sweep of SARS-CoV-2: from Chaos to Order
Wang, X.; Hu, M.; Jin, Y.; Wang, B.; Zhao, Y.; Liang, L.; Yue, J.; Ren, H.
10.1101/2021.11.16.468834 — evolutionary biology — Posted on 2021-11-17
1679 Estrogen-related receptor alpha and Rplp1 ribosome protein-dependent translation coordinately regulate starvation response and decrease NASH progression
Tripathi, M.; Gauthier, K.; Sandireddy, R.; Zhou, J.; Tikno, K.; Arul, K.; Park, S.-H.; Wu, Y.; Bay, B. H.; Giguere, V.; Chow, P. K. H.; McDonnell, D. P.; Yen, P. M.; Singh, B. K.
10.1101/2021.11.16.468891 — molecular biology — Posted on 2021-11-17
1680 Recognition and deubiquitination of free 40S for translational reset by Otu2
Ikeuchi, K.; Ivic, N.; Cheng, J.; Buschauer, R.; Matsuo, Y.; Froehlich, T.; Berninghausen, O.; Inada, T.; Becker, T.; Beckmann, R.
10.1101/2021.11.17.468975 — molecular biology — Posted on 2021-11-17
1681 The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells
Nchioua, R.; Schundner, A.; Klute, S.; Noettger, S.; Zech, F.; Koepke, L.; Graf, A.; Krebs, S.; Blum, H.; Kmiec, D.; Frick, M.; Kirchhoff, F.; Sparrer, K.
10.1101/2021.11.16.468777 — microbiology — Posted on 2021-11-17
1684 Tuning spherical cells into kinking helices in wall-less bacteria
Lartigue, C.; Lambert, B.; Rideau, F.; Decossas, M.; Hillion, M.; Douliez, J.-P.; Hardouin, J.; Lambert, O.; Blanchard, A.; Beven, L.
10.1101/2021.11.16.467908 — microbiology — Posted on 2021-11-17
1685 Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice
Olivarria, G. M.; Cheng, Y.; Pachow, C.; Hohsfield, L. A.; Smith-Geater, C.; Miramontes, R.; Wu, J.; Burns, M. S.; Tsourmas, K. I.; Stocksdale, J.; Manlapaz, C.; Furman, S.; Yong, W. H.; Teijaro, J.; Edwards, R. A.; Green, K.; Thompson, L. M.; Lane, T.
10.1101/2021.11.15.468761 — microbiology — Posted on 2021-11-17
1686 Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant
Gaudreault, N. N.; Cool, K.; Trujillo, J. D.; Morozov, I.; Meekins, D. A.; McDowell, C. D.; Bold, D.; Carossino, M.; Balaraman, V.; Mitzel, D.; Kwon, T.; Madden, D. W.; Artiaga, B. L.; Pogranichniy, R.; Roman-Sosa, G.; Wilson, W. C.; Balasuriya, U. B.; Garcia-Sastre, A.; Richt, J. A.
10.1101/2021.11.15.468720 — microbiology — Posted on 2021-11-17
1687 NMR metabolomics of symbioses between bacterial vaginosis associated bacteria
Horrocks, V.; Hind, C. K.; Wand, M. E.; Chan, J.; Hopkins, J. C.; Houston, G. L.; Tribe, R. M.; Sutton, J. M.; Mason, A. J.
10.1101/2021.11.17.468714 — microbiology — Posted on 2021-11-17
1688 The mycobacterial mutasome: composition and recruitment in live cells
Gessner, S.; Martin, Z. A.-M.; Reiche, M. A.; Santos, J.; Dhar, N.; Dinkele, R.; de Wet, T. J.; Ramudzuli, A.; Anoosheh, S.; Lang, D. M.; Aaron, J.; Chew, T. L.; Herrmann, J.; Mueller, R.; McKinney, J. D.; Woodgate, R.; Mizrahi, V.; Lamers, M.; Warner, D. F.
10.1101/2021.11.16.468908 — microbiology — Posted on 2021-11-17
1690 Identification of a minimal biomarker profile in head-and-neck squamous cell carcinoma tumors
Sanchez-Diaz, L.; Navas, L. E.; Suarez-Martinez, E.; Felipe-Abrio, B.; Fernandez-Rozadilla, C.; Verdugo-Sivianes, E. M.; Celis-Romero, M. A.; Chaves-Conde, M.; Chiara, M.-D.; Garcia-Mayea, Y.; LLeonart, M. E.; Garcia-Heredia, J. M.; Munoz-Galvan, S.; Carracedo, A.; Rodrigo, J. P.; Carnero, A.
10.1101/2021.11.12.468359 — cancer biology — Posted on 2021-11-17
1692 BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes
Kalejaiye, T. D.; Bhattacharya, R.; Burt, M. A.; Travieso, T.; Okafor, A. E.; Mou, X.; Blasi, M.; Musah, S.
10.1101/2021.11.16.468893 — bioengineering — Posted on 2021-11-17
1695 A Novel Ex Vivo Peritoneal Model to Investigate Mechanisms of Peritoneal Metastasis in Gastric Adenocarcinoma
Ng, D.; Ali, A.; Lee, K.; Eymael, D.; Abe, K.; Luu, S.; Brar, S.; Conner, J.; Magalhaes, M.; Swallow, C. J.
10.1101/2021.11.15.468687 — cancer biology — Posted on 2021-11-17
1697 Simultaneous stereo-EEG and high-density scalp EEG recordings to study the effects of intracerebral stimulation parameters
Parmigiani, S.; Mikulan, E. P.; Russo, S.; Sarasso, S.; Zauli, F. M.; Rubino, A.; Cattani, A.; Fecchio, M.; Giampiccolo, D.; Lanzone, J.; D'Orio, P.; Del Vecchio, M.; Avanzini, P.; Nobili, L.; Sartori, I. M.; Massimini, M.; Pigorini, A.
10.1101/2021.11.15.468625 — neuroscience — Posted on 2021-11-17
1698 Auricular transcutaneous vagus nerve stimulation acutely modulates brain connectivity in mice
Pisoni, C. B.; Moreno, E. M.; Amaro, I. G.; Maldonado, R.; Ivorra, A.; Soria, G.; Ozaita, A.
10.1101/2021.11.15.468252 — neuroscience — Posted on 2021-11-17
1707 Home literacy environment mediates the relationship between socioeconomic status and white matter structure in infants
Turesky, T. K.; Sanfilippo, J.; Zuk, J.; Ahtam, B.; Gagoski, B.; Lee, A.; Garrisi, K.; Dunstan, J.; Carruthers, C.; Vanderauwera, J.; Yu, X. K.; Gaab, N.
10.1101/2021.11.13.468500 — neuroscience — Posted on 2021-11-17
1723 Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network
Oyarzabal, E. A.; Hsu, L.; Das, M.; Chao, T.-H. H.; Zhou, J.; Song, S.; Zhang, W.; Smith, K. G.; Sciolino, N. R.; Evsyukova, I. Y.; Yuan, H.; Lee, S.-H.; Cui, G.; Jensen, P.; Shih, Y.-Y. I.
10.1101/2021.10.28.463794 — neuroscience — Posted on 2021-11-17
1725 GABAergic GABRA5-positive Projection Neurons in Lateral Hypothalamic Area Control Obesity via Astrocytic GABA
Sa, M.; Yoo, E.-S.; Koh, W.; Park, M. G.; Jang, H.-J.; Yang, Y. R.; Lim, J.; Won, W.; Kwon, J.; Bhalla, M.; An, H.; Seong, Y.; Park, K. D.; Suh, P.-G.; Sohn, J.-W.; Lee, C. J. J.
10.1101/2021.11.07.467613 — neuroscience — Posted on 2021-11-17
1728 De novo designed transmembrane domains tune engineered receptor functions
Elazar, A.; Chandler, N. J.; Davey, A. S.; Weinstein, J. Y.; Nguyen, J. V.; Trenker, R.; Jenkins, M. R.; Call, M. J.; Call, M. E.; Fleishman, S. J.
10.1101/2020.07.26.221598 — synthetic biology — Posted on 2021-11-17
1733 Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32
Mi, C.; Zhang, L.; Sun, S.; Huang, G.; Shao, G.; Yang, F.; You, X.; Dong, M.-Q.; Sui, S.-F.
10.1101/2021.11.11.468031 — biophysics — Posted on 2021-11-17
1734 A high-throughput amplicon sequencing approach for population-wide species diversity and composition survey
Tay, W. T.; Court, L. N.; Macfadyen, S.; Jacomb, F.; Vyskocilova, S.; Colvin, J.; De Barro, P. J.
10.1101/2020.10.12.336545 — evolutionary biology — Posted on 2021-11-17
1736 In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Imanishi, S.; Huang, L.; Itakura, S.; Ishizaka, M.; Iwasaki, Y.; Yamaguchi, T.; Miyamoto-Sato, E.
10.1101/2021.04.23.441075 — molecular biology — Posted on 2021-11-17
1738 Body schema plasticity is altered in Developmental Coordination Disorder
Martel, M.; Boulenger, V.; Koun, E.; Finos, L.; Farne, A.; Roy, A. C.
10.1101/2021.08.16.456453 — neuroscience — Posted on 2021-11-17
1739 Multi-locus transcranial magnetic stimulation system for electronically targeted brain stimulation
Nieminen, J. O.; Sinisalo, H.; Souza, V. H.; Malmi, M.; Yuryev, M.; Tervo, A. E.; Stenroos, M.; Milardovich, D.; Korhonen, J. T.; Koponen, L. M.; Ilmoniemi, R. J.
10.1101/2021.09.20.461045 — neuroscience — Posted on 2021-11-17
1744 The sequences of 150,119 genomes in the UK biobank
Halldorsson, B. V.; Eggertsson, H. P.; Moore, K. H. S.; Hauswedell, H.; Eiriksson, O.; Ulfarsson, M. O.; Palsson, G.; Hardarson, M. T.; Oddsson, A.; Jensson, B. O.; Kristmundsdottir, S.; Sigurpalsdottir, B. D.; Stefansson, O. A.; Beyter, D.; Holley, G.; Tragante, V.; Gylfason, A.; Olason, P. I.; Zink, F.; Asgeirsdottir, M.; Sverrisson, S. T.; Sigurdsson, B.; Gudjonsson, S. A.; Sigurdsson, G. T.; Halldorsson, G. H.; Sveinbjornsson, G.; Norland, K.; Styrkarsdottir, U.; Magnusdottir, D. N.; Snorradottir, S.; Kristinsson, K.; Sobech, E.; Thorleifsson, G.; Jonsson, F.; Melsted, P.; Jonsdottir, I.;
10.1101/2021.11.16.468246 — genetics — Posted on 2021-11-17
1748 Optimal information loading into working memory in prefrontal cortex
Stroud, J. P.; Watanabe, K.; Suzuki, T.; Stokes, M. G.; Lengyel, M.
10.1101/2021.11.16.468360 — neuroscience — Posted on 2021-11-17
1751 Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity
Belhimeur, S.; Briquet, S.; Peronet, R.; Pham, J.; Commere, P.-H.; Amino, R.; Scherf, A.; Silvie, O.; MECHERI, S.
10.1101/2021.11.16.468835 — immunology — Posted on 2021-11-16
1756 Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy
Qin, J.; Zhang, J.; Lin, L.; Haji-Ghassemi, O.; Lin, Z.; Woycechowsky, K. J.; van Petegem, F.; Zhang, Y.; Yuchi, Z.
10.1101/2021.11.16.468845 — biochemistry — Posted on 2021-11-16
1757 RNA-guided AsCas12a- and SpCas9-catalyzed knockout and homology directed repair of the omega-1 locus of the human blood fluke, Schistosoma mansoni
Tanno, W. I.; Chatupheeraphat, C.; Mann, V. H.; Li, W.; Miller, A.; Ogunbayo, T.; Tran, K.; Alrefael, Y.; Mentink-Kane, M.; Brindley, P. J.
10.1101/2021.11.15.468743 — molecular biology — Posted on 2021-11-16
1760 Direct regulation of cell cycle regulatory gene expression by NtrX to promote Sinorhizobium meliloti cell division
Luo, L.; Xing, S.; Zhang, L.; An, F.; Huang, L.; Yang, X.; Zeng, S.; Li, N.; Zheng, W.; Ouenzar, K.; Yu, L.
10.1101/2021.11.15.468759 — microbiology — Posted on 2021-11-16
1763 A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
Drozdz, M. M.; Doane, A. S.; Alkallas, R.; Desman, G.; Bareja, R.; Reilly, M.; Bang, J.; Yusupova, M.; You, J.; Wang, J. Z.; Verma, A.; Aguirre, K.; Kane, E.; Watson, I. R.; Elemento, O.; Piskounova, E.; Merghoub, T.; Zippin, J. H.
10.1101/2021.11.15.468656 — cancer biology — Posted on 2021-11-16
1765 Binding stoichiometry and structural model of the HIV-1 Rev/Importin beta complex
Spittler, D.; Indorato, R.-L.; Boeri Erba, E.; Delaforge, E.; Signor, L.; Harris, S. J.; Garcia Saez, I.; PALENCIA, A.; Gabel, F.; Blackledge, M.; Noirclerc-Savoye, M.; Petosa, C.
10.1101/2021.11.16.468785 — biochemistry — Posted on 2021-11-16
1770 Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and protection of anaphylaxis
Le, T. N. U.; Nguyen, T. Q.; Nguyen, Y. T. K.; Tan, C. K. H.; Tukijan, F.; Couty, L.; Hasan, M. Z.; Kalailingam, P.; Wenk, M. R.; Cazenave-Gassiot, A.; Camerer, E.; Nguyen, L. N.
10.1101/2021.11.15.468739 — molecular biology — Posted on 2021-11-16
1774 Effects of Chronic Intermittent Hypoxia and Chronic Sleep Fragmentation on Gut Microbiome, Serum Metabolome, Liver and Adipose Tissue Morphology
Wang, F.; Zou, J.; Xu, H.; Huang, W.; Zhang, X.; Li, X.; Liu, Y.; Zou, J.; Liu, F.; Zhu, H.; Yi, H.; Guan, J.; Yin, S.
10.1101/2021.11.15.468769 — microbiology — Posted on 2021-11-16
1775 Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody
Callaway, H. M.; Zyla, D.; Hastie, K. M.; Avalos, R. D.; Agarwal, A.; Bourhy, H.; Corti, D.; Saphire, E. O.
10.1101/2021.11.16.468852 — microbiology — Posted on 2021-11-16
1776 Whole-brain fluorescence-MRI coregistration for precise anatomical mapping of virus infection
Chotiwan, N.; Willekens, S. M. A.; Schexnaydre, E.; Hahn, M.; Morini, F.; Zhang, J.; Nilsson, E.; Carlson, L.-A.; Ahlgren, U.; Marcellino, D.; Overby, A. K.
10.1101/2021.11.16.468804 — microbiology — Posted on 2021-11-16
1778 Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axis
Dias-Carvalho, P.; Martins, F.; Mendonca, S.; Ribeiro, A.; Machado, A. L.; Carvalho, J.; Oliveira, M. J.; Velho, S.
10.1101/2021.11.16.468815 — cancer biology — Posted on 2021-11-16
1781 Electrochemical biosensors based on peptide-kinase interactions at the kinase docking site
Joshi, P. N.; Mervinetsky, E.; Solomon, O.; Chen, Y.-J.; Yitzchaik, S.; Friedler, A.
10.1101/2021.11.16.468793 — biochemistry — Posted on 2021-11-16
1784 Estimating population size when individuals are asynchronous: a model illustrated with northern elephant seal breeding colonies
Condit, R.; Allen, S. G.; Costa, D. P.; Codde, S.; Goley, P. D.; Le Boeuf, B. J.; Lowry, M. S.; Morris, P.
10.1101/2020.12.01.368605 — ecology — Posted on 2021-11-16
1792 In vivo reprogramming of murine host immune response genes following Leishmania major infection.
Venugopal, G.; Bird, J. T.; Washam, C. L.; Roys, H.; Bowlin, A.; Byrum, S. D.; Weinkopff, T.
10.1101/2021.10.05.463063 — immunology — Posted on 2021-11-16
1801 Cbln1 regulates axon growth and guidance in multiple neural regions
Ji, S.-J.; Han, P.; She, Y.; Yang, Z.; Zhuang, M.; Wang, Q.; Luo, X.; Yin, C.; Zhu, J.; Jaffrey, S. R.
10.1101/2021.11.16.468844 — neuroscience — Posted on 2021-11-16
1803 Mitochondrial fission is increased in macrophages during mROS production in response to S. pneumoniae
Mohasin, M.; Balbirnie-Cumming, K.; Fisk, E.; Prestwich, E. C.; Russell, C. D.; Marshall, J.; Pridans, C.; Allen, S. P.; Shaw, P. J.; De Vos, K. J.; Hill, C. J.; Bullough, P.; Condliffe, A. M.; Mitchell, T. J.; Marriott, H. M.; Dockrell, D. H.
10.1101/722603 — immunology — Posted on 2021-11-16
1804 Using OPM-MEG in contrasting magnetic environments
Hill, R. M.; Devasagayam, J.; Holmes, N.; Boto, E.; Shah, V.; Osborne, J.; Safar, K.; Worcester, F.; Mariani, C.; Dawson, E.; Woolger, D.; Bowtell, R.; Taylor, M.; Brookes, M. J.
10.1101/2021.11.15.468615 — neuroscience — Posted on 2021-11-16
1805 The Genomic Prehistory of the Indigenous People of Uruguay
Lindo, J.; Campelo dos Santos, A. L.; DeGiorgio, M.; Figueiro, G.
10.1101/2021.11.11.468260 — genomics — Posted on 2021-11-16
1808 Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
Bussy, A.; Levy, J.; Patel, R.; Cupo, L.; Best, T.; Van Langenhove, T.; Nielsen, J.; Pijnenburg, Y.; Landqvist Waldö, M.; Remes, A.; Schroeter, M. L.; Santana, I.; Pasquier, F.; Otto, M.; Danek, A.; Levin, J.; Le Ber, I.; Vandenberghe, R.; Synofzik, M.; Moreno, F.; de Mendonca, A.; Sanchez-Valle, R.; Laforce, R.; Langheinrich, T.; Gerhard, A.; Graff, C.; Butler, C. R.; Sorbi, S.; Jiskoot, L.; Seelaar, H.; van Swieten, J. C.; Finger, E.; Tartaglia, M. C.; Masellis, M.; Tiraboschi, P.; Galimberti, D.; Borroni, B.; Rowe, J.; Bocchetta, M.; Rohrer, J. D.; Devenyi, G. A.; Chakravarty, M. M.; Ducha
10.1101/2021.11.12.468429 — neuroscience — Posted on 2021-11-16
1809 Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure
Roth, K.; Strickland, J.; Gonzalez-Pons, R.; Pant, A.; Yen, T.-C.; Freeborn, R.; Kennedy, R.; Bhushan, B.; Boss, A.; Rockwell, C. E.; Dorrance, A. M.; Apte, U.; Luyendyk, J. P.; Copple, B. L.
10.1101/2021.11.15.468664 — pathology — Posted on 2021-11-16
1811 A general design of caging-group free photoactivatable fluorophores for live-cell nanoscopy
Lincoln, R.; Bossi, M. L.; Remmel, M.; D'Este, E.; Butkevich, A. N.; Hell, S. W.
10.1101/2021.11.15.468659 — biochemistry — Posted on 2021-11-16
1819 Extensive gene duplication in Arabidopsis revealed by pseudo-heterozygosity
Jaegle, B.; Soto-Jimenez, L. M.; Burns, R.; Rabanal, F. A.; Nordborg, M.
10.1101/2021.11.15.468652 — genomics — Posted on 2021-11-16
1820 A trans-acting long non-coding RNA represses flowering in Arabidopsis
Jin, Y.; Ivanov, M.; Dittrich, A. N.; Nelson, A.; Marquardt, S.
10.1101/2021.11.15.468639 — genomics — Posted on 2021-11-16
1821 A framework for evaluating edited cell libraries created by massively parallel genome engineering
Cawley, S.; Abbate, E.; Abraham, C. G.; Alvarez, S.; Barber, M.; Bolte, S.; Bruand, J.; Church, D. M.; Davis, C.; Estes, M.; Federowicz, S.; Fox, R.; Gander, M. W.; Garst, A. D.; Gencer, G.; Halweg-Edwards, A. L.; Hardenbol, P.; Hraha, T.; Jain, S.; Johnson, C.; Juneau, K.; Krishnamurthy, N.; Lambert, S.; Leland, B.; Pearson, F.; Ray, J. C. J.; Sanada, C. D.; Shaver, T. M.; Shepherd, T. R.; Shorenstein, J.; Spindler, E. C.; Struble, C. A.; Swat, M. H.; Tanner, S.; Tian, T.; Wishart, K.; Graige, M. S.
10.1101/2021.09.23.458228 — genomics — Posted on 2021-11-16
1823 Phylogenomic discordance suggests polytomies along the backbone of the large genus Solanum
Gagnon, E.; Hilgenhof, R.; Orejuela, A.; McDonnell, A.; Sablok, G.; Aubriot, X.; Giacomin, L.; Gouvea, Y.; Bragionis, T.; Stehmann, J. R.; Bohs, L.; Dodsworth, S.; Martine, C. T.; Poczai, P.; Knapp, S.; Särkinen, T.
10.1101/2021.03.25.436973 — evolutionary biology — Posted on 2021-11-16
1827 SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression
Salasova, A.; Degn, N. S.; Paveliev, M.; Madsen, N. K.; Benito, S.; Casarotto, P.; Ovesen, P. L.; Vestergaard, B.; Udrea, A. C.; Kisiswa, L.; Woloszczukova, L.; Faress, I.; Nabavi, S.; Castren, E.; Arevalo, J.; Holm, M. M.; Kjolby, M.; Bolcho, U.; Nykjaer, A.
10.1101/2021.11.03.466767 — neuroscience — Posted on 2021-11-16
1830 Improved two-photon imaging of GPCR-based optogenetic neurotransmitter sensors using orthogonally polarized excitation
Pulin, M.; Stockhausen, K. E.; Masseck, O. A.; Kubitschke, M.; Busse, B.; Wiegert, J. S.; Oertner, T. G.
10.1101/2021.11.15.468606 — neuroscience — Posted on 2021-11-16
1832 PPAR-delta acts as a metabolic master checkpoint for metastasis in pancreatic cancer
Parejo-Alonso, B.; Barneda, D.; Trabulo, S. M.; Courtois, S.; Compte-Sancerni, S.; Ruiz-Canas, L.; Zheng, Q.; Tang, J.; Chen, M.; Guo, Z.; Schmitz, U.; Irun, P.; Penin-Peyta, L.; Crusz, S. M.; Cano-Galiano, A.; Lopez-Escalona, S.; Jagust, P.; Espiau-Romera, P.; Yuneva, M.; Lin, M.-L.; Lanas, A.; Sainz, B.; Heeschen, C.; Sancho, P.
10.1101/2021.11.15.468579 — cancer biology — Posted on 2021-11-16
1836 A genomic and morphometric analysis of alpine bumblebees: ongoing reductions in tongue length but no clear genetic component
Christmas, M. J.; Jones, J. C.; Olsson, A.; Wallerman, O.; Bunikis, I.; Kierczak, M.; Whitley, K. M.; Sullivan, I.; Geib, J. C.; Miller-Struttmann, N. E.; Webster, M. T.
10.1101/2021.03.17.435598 — evolutionary biology — Posted on 2021-11-16
1837 Artificial selection for predatory behavior results in dietary niche differentiation in an omnivorous mammal
Hämäläinen, A. M.; Kiljunen, M.; Koskela, E.; Koteja, P.; Mappes, T.; Rajala, M.; Tiainen, K.
10.1101/2021.11.15.468574 — ecology — Posted on 2021-11-16
1838 Both consumptive and non-consumptive effects of predators impact mosquito populations and have implications for disease transmission
Russell, M. C.; Herzog, C. M.; Gajewski, Z.; Ramsay, C.; El Moustaid, F.; Evans, M. V.; Desai, T.; Gottdenker, N.; Hermann, S.; Power, A. G.; McCall, A. C.
10.1101/2021.07.31.454599 — ecology — Posted on 2021-11-16
1840 Nascent adhesions differentially regulate lamellipodium velocity and persistence
Carney, K. R.; Khan, A. M.; Samson, S. C.; Mittal, N.; Han, S. J.; Mendoza, M. C.; Bidone, T. C.
10.1101/2021.11.15.468602 — cell biology — Posted on 2021-11-16
1845 Function of FMRP domains in regulating distinct roles of neuronal protein synthesis
D'Souza, M. N.; Ramakrishna, S.; Radhakrishna, B. K.; Jhaveri, V.; Ravindran, S.; Yeramala, L.; Palakodeti, D.; Muddashetty, R. S.
10.1101/2021.11.15.468563 — neuroscience — Posted on 2021-11-16
1847 Male mate choice unresolved in the mangrove rivulus
Gresham, J. D.; Bowman, S. N.; Keck, C. M. T.; Quertermous, H. M.; Earley, R. L.
10.1101/2021.02.22.432326 — animal behavior and cognition — Posted on 2021-11-16
1848 Genome-wide association, prediction and heritability in bacteria
Mallawaarachchi, S.; Tonkin-Hill, G.; Croucher, N. J.; Turner, P.; Speed, D.; Corander, J.; Balding, D.
10.1101/2021.10.04.462983 — genomics — Posted on 2021-11-16
1849 Variation in self-compatibility among genotypes and across ontogeny in a self-fertilizing vertebrate
Gresham, J. D.; Earley, R. L.; Clark, A.; Keck, C. M. T.; Longmire, A. E.; Nelson, A. E.; Quertermous, H. M.
10.1101/2021.02.22.432320 — evolutionary biology — Posted on 2021-11-16
1854 Social Reactivation of Fear Engrams Enhances Memory Recall
Finkelstein, A. B.; Leblanc, H.; Cole, R.; Gallerani, T.; Vieira, A.; Zaki, Y.; Ramirez, S.
10.1101/2021.01.07.425728 — neuroscience — Posted on 2021-11-16
1856 Biophysical characterization of the oligomeric states of recombinant Immunoglobulins type-M and their C1q binding kinetics by Biolayer Interferometry
Chouquet, A.; Pinto, A. J.; Hennicke, J.; Ling, W. L. W.; Bally, I.; Schwaigerlehner, L.; Thielens, N. M.; Kunert, R.; REISER, J.-B.
10.1101/2021.09.30.460443 — bioengineering — Posted on 2021-11-16
1857 MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation
Romero-Becerra, R.; Mora, A.; Manieri, E.; Sanz, L.; Nikolic, I.; Santamans, A. M.; Montalvo-Romeral, V.; Cruz, F. M.; Rodriguez, E.; Leiva-Vega, L.; Bondia, V.; Filgueiras-Rama, D.; Jimenez-Borreguero, L. J.; Jalife, J.; Gonzalez-Teran, B.; Sabio, G.
10.1101/2021.11.15.468612 — molecular biology — Posted on 2021-11-16
1859 Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors
Ludikhuize, M. C.; Gevers, S.; Nguyen, N. T. B.; Meerlo, M.; Shafiei Roudbari, S. K.; Gulersonmez, M. C.; Stigter, E. C. A.; Drost, J.; Clevers, H. C.; Burgering, B. M.; RodrIguez-Colman, M. J.
10.1101/2021.11.11.468185 — cancer biology — Posted on 2021-11-16
1860 The evolution of widespread recombination suppression on the Dwarf Hamster (Phodopus) X chromosome
Moore, E. C.; Thomas, G. W. C.; Mortimer, S.; Kopania, E. E. K.; Hunnicutt, K. E.; Clare-Salzler, Z. J.; Larson, E. E.; Good, J. M.
10.1101/2021.11.15.468705 — genomics — Posted on 2021-11-16
1861 Oligogenic heterozygous inheritance of sperm abnormalities in mouse
Martinez, G.; Coutton, C.; Loeuillet, C.; Cazin, C.; Muronova, J.; Boguenet, M.; Lambert, E.; Dhellemmes, M.; Chevalier, G.; Hograindleur, J.-P.; Vilpreux, C.; Neirijnck, Y.; Kherraf, Z. E.; Escoffier, J.; Nef, S.; F. Ray, P.; Arnoult, C.
10.1101/2021.11.15.468601 — genetics — Posted on 2021-11-16
1862 Telomerase and Alternative Lengthening of Telomeres coexist in the regenerating zebrafish caudal fins
Cayuela, M. L.; Martinez-Balsalobre, E.; Anchelin-Flageul, M.; Alcaraz-Perez, F.; Garcia-Castillo, J.; Hernandez-Silva, D.; Mione, M.; Mulero, V.
10.1101/2021.11.15.468592 — genetics — Posted on 2021-11-16
1863 Reassortment Network of Influenza A Virus
Gong, X.; Hu, M.; Chen, W.; Yang, H.; Wang, B.; Yue, J.; Jin, Y.; Liang, L.; Ren, H.
10.1101/2021.09.09.459621 — evolutionary biology — Posted on 2021-11-16
1865 Polo-like kinase 4 homodimerization is not required for catalytic activation, autodestruction, or centriole assembly
Ryniawec, J. M.; Buster, D. W.; Slevin, L. K.; Boese, C. J.; Amoiroglou, A.; Dean, S.; Slep, K. C.; Rogers, G. C.
10.1101/2021.11.15.468682 — cell biology — Posted on 2021-11-16
1868 Clostridioides difficile phosphoproteomics shows an expansion of phosphorylated proteins in stationary growth phase
Smits, W. K.; Mohammed, Y.; de Ru, A. H.; Cordo, V.; Friggen, A. H.; van Veelen, P. A.; Hensbergen, P. J.
10.1101/2021.11.11.468335 — microbiology — Posted on 2021-11-16
1869 Activation of NLRP3 Inflammasome by Virus-like Particles of Human Polyomaviruses in Macrophages
Luciunait?, A.; Dalgediene, I.; Zilionis, R.; Masalaite, K.; Sinkunas, A.; Norkiene, M.; Gedvilaite, A.; Kucinskait?-Kodze, I.; Zvirbliene, A.
10.1101/2021.11.15.468577 — immunology — Posted on 2021-11-16
1870 River network rearrangements promote speciation in lowland Amazonian birds
Musher, L. J.; Giakoumis, M.; Albert, J.; Del Rio, G.; Rego, M.; Thom, G.; Aleixo, A.; Ribas, C. C.; Brumfield, R. T.; Smith, B. T.; Cracraft, J.
10.1101/2021.11.15.468717 — evolutionary biology — Posted on 2021-11-16
1875 Distinct properties in ventral pallidum projection neuron subtypes
Bernat, N.; Campbell, R.; Nam, H.; Basu, M.; Odesser, T.; Elyasaf, G.; Engeln, M.; Chandra, R.; Golden, S.; Ament, S.; Lobo, M. K.; Kupchik, Y.
10.1101/2021.11.15.468637 — neuroscience — Posted on 2021-11-16
1876 Genetic coupling of life-history and aerobic performance in Atlantic salmon indicates potential for coevolution across life-stages
Prokkola, J. M.; Asheim, E. R.; Morozov, S.; Bangura, P.; Erkinaro, J.; Ruokolainen, A.; Primmer, C. R.; Aykanat, T.
10.1101/2021.08.23.457324 — evolutionary biology — Posted on 2021-11-16
1878 Spatiotemporal organization of movement-invariant and movement-specific signaling in the output layer of motor cortex
Currie, S. P.; Ammer, J.; Premchand, B.; Dacre, J.; Wu, Y.; Eleftheriou, C.; Colligan, M.; Clarke, T.; Mitchell, L.; Faisal, A. A.; Hennig, M. H.; Duguid, I.
10.1101/2020.10.27.357087 — neuroscience — Posted on 2021-11-16
1881 Protein-coding potential of RNAs measured by potentially translated island scores
Suenaga, Y.; Kato, M.; Nagai, M.; Nakatani, K.; Kogashi, H.; Kobatake, M.; Makino, T.
10.1101/2021.04.14.439730 — evolutionary biology — Posted on 2021-11-16
1884 A Marmoset Model for Mycobacterium avium Complex Pulmonary Disease
Peters, J.; Maselli, D. J.; Mangat, M.; Coalson, J. J.; Hinojosa, C.; Giavedoni, L.; Brown-Elliott, B.; Chan, E.; Griffith, D.
10.1101/2021.11.15.468600 — microbiology — Posted on 2021-11-15
1890 An atypical NLR protein modulates the NRC immune receptor network
Adachi, H.; Sakai, T.; Harant, A.; Duggan, C.; Bozkurt, T.; Wu, C.-H.; Kamoun, S.
10.1101/2021.11.15.468391 — plant biology — Posted on 2021-11-15
1891 Effector loss drives adaptation of Pseudomonas syringae pv. actinidiae to Actinidia arguta
Hemara, L. M.; Jayaraman, J.; Sutherland, P.; Montefiori, M.; Arshed, S.; Chatterjee, A.; Chen, R.; Andersen, M. T.; Mesarich, C. H.; van der Linden, O.; Schipper, M. M.; Vanneste, J. L.; Brendolise, C.; Templeton, M. D.
10.1101/2021.11.15.468702 — plant biology — Posted on 2021-11-15
1892 A cell wall-associated gene network shapes leaf boundary domains
Boure, N.; Peaucelle, A.; Goussot, M.; Adroher, B.; Soubigou-Taconnat, L.; Biot, E.; Tariq, Z.; Martin-Magniette, M.-L.; Laufs, P.; Arnaud, N.
10.1101/2021.11.15.468678 — plant biology — Posted on 2021-11-15
1893 Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL
Bruch, P.-M.; Giles, H. A. R.; Kolb, C.; Herbst, S. A.; Becirovic, T.; Roider, T.; Lu, J.; Scheinost, S.; Wagner, L.; Huellein, J.; Berest, I.; Kriegsmann, M.; Kriegsmann, K.; Zgorzelski, C.; Dreger, P.; Zaugg, J. B.; Müller-Tidow, C.; Zenz, T.; Huber, W.; Dietrich, S.
10.1101/2021.07.23.453514 — cancer biology — Posted on 2021-11-15
1894 Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms
Hesgrove, C. S.; Nguyen, K. H.; Biswas, S.; Childs, C. A.; KC, S.; Medina, B. X.; Alvarado, V.; Sukenik, S.; Yu, F.; Malferrari, M.; Francia, F.; Venturoli, G.; Martin, E. W.; Holehouse, A. S.; Boothby, T. C.
10.1101/2021.08.16.456555 — biophysics — Posted on 2021-11-15
1895 TransportTools: a library for high-throughput analyses of internal voids in biomolecules and ligand transport through them
Brezovsky, J.; Thirunavukarasu, A. S.; Surpeta, B.; Sequeiros-Borja, C. E.; Mandal, N.; Sarkar, D. K.; Dongmo Foumthuim, C. J.; Agrawal, N.
10.1101/2021.06.01.445451 — bioinformatics — Posted on 2021-11-15
1901 Efficient inhibition of cell proliferation and promotion of apoptosis requires continuous treatment with abemaciclib.
Torres-Guzman, R.; Ganado, M. P.; Mur, C.; Marugan, C.; Baquero, C.; Yang, Y.; Zeng, Y.; Bian, H.; Du, J.; de Dios, A.; Puig, O.; Lallena, M. J.
10.1101/2021.11.15.468648 — cell biology — Posted on 2021-11-15
1902 A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations
Sturm, G.; Monzel, A. S.; Karan, K. R.; Michelson, J.; Ware, S. A.; Cardenas, A.; Lin, J.; Bris, C.; Santhanam, B.; Murphy, M. P.; Levine, M. E.; Horvath, S.; Belsky, D. W.; Wang, S.; Procaccio, V.; Kaufman, B. A.; Hirano, M.; Picard, M.
10.1101/2021.11.12.468448 — cell biology — Posted on 2021-11-15
1903 Wolbachia endosymbionts in two Anopheles species indicates independent acquisitions and lack of prophage elements
Quek, S.; Cerdeira, L. T.; Jeffries, C. L.; Tomlinson, S. L.; Walker, T.; Hughes, G. L.; Heinz, E.
10.1101/2021.11.15.468614 — cell biology — Posted on 2021-11-15
1904 Global landscape of replicative DNA polymerase usage in the human genome
Koyanagi, E.; Kakimoto, Y.; Yoshifuji, F.; Natsume, T.; Higashitani, A.; Ogi, T.; Carr, A. M.; Kanemaki, M. T.; Daigaku, Y.
10.1101/2021.11.14.468503 — molecular biology — Posted on 2021-11-15
1908 Engineering T cell resistance to HIV-1 infection via knock-in of peptides from the heptad repeat 2 domain of gp41
Maslennikova, A.; Kruglova, N.; Kalinichenko, S.; Komkov, D.; Shepelev, M.; Golubev, D.; Siniavin, A.; Vzorov, A.; Filatov, A.; Mazurov, D.
10.1101/2021.04.30.442168 — microbiology — Posted on 2021-11-15
1909 Regulatory T cells suppress the formation of super-effector CD8 T cells by limiting IL-2
Tsyklauri, O.; Chadimova, T.; Niederlova, V.; Kovarova, J.; Michalik, J.; Malatova, I.; Janusova, S.; Rossez, H.; Drobek, A.; Vecerova, H.; Galati, V.; Kovar, M.; Stepanek, O.
10.1101/2021.11.10.467495 — immunology — Posted on 2021-11-15
1910 Not all voxels are created equal: reducing estimation bias in regional NODDI metrics using tissue-weighted means
Parker, C. S.; Veale, T.; Bocchetta, M.; Slattery, C. F.; Malone, I. B.; Thomas, D. L.; Schott, J. M.; Cash, D. M.; Zhang, H.
10.1101/2021.06.29.450089 — neuroscience — Posted on 2021-11-15
1911 Neural vulnerability and hurricane-related media are associated with post-traumatic stress in youth
Dick, A. S.; Silva, K.; Gonzalez, R.; Sutherland, M. T.; Laird, A. R.; Thompson, W. K.; Tapert, S. F.; Squeglia, L. M.; Gray, K. M.; Nixon, S. J.; Cottler, L. B.; La Greca, A. M.; Gurwitch, R. H.; Comer, J. S.
10.1101/2020.08.27.271056 — neuroscience — Posted on 2021-11-15
1912 Long-term effects of network-based fMRI neurofeedback training for sustained attention
Pamplona, G. S. P.; Heldner, J.; Langner, R.; Koush, Y.; Michels, L.; Ionta, S.; Garrido Salmon, C. E.; Scharnowski, F.
10.1101/2021.10.27.465722 — neuroscience — Posted on 2021-11-15
1913 The Neural Determinants of Beauty
Yang, T.; Formuli, A.; Paolini, M.; Zeki, S.
10.1101/2021.05.21.444999 — neuroscience — Posted on 2021-11-15
1917 Artifacts in EEG-based BCI therapies: friend or foe?
McDermott, E. J.; Raggam, P.; Kirsch, S.; Belardinelli, P.; Ziemann, U.; Zrenner, C.
10.1101/2021.10.27.466131 — neuroscience — Posted on 2021-11-15
1919 Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation
Mauersberger, C.; Sager, H. B.; Wobst, J.; Dang, T. A.; Lambrecht, L.; Koplev, S.; Stroth, M.; Bettaga, N.; Schlossmann, J.; Wunder, F.; Friebe, A.; Bjoerkegren, J. L.; Dietz, L.; Sandner, P.; Soehnlein, O.; Schunkert, H.; Kessler, T.
10.1101/2021.11.15.467680 — physiology — Posted on 2021-11-15
1920 Engraftment of allotransplantated tumour cells in adult rag2 mutant Xenopus tropicalis
Tulkens, D.; Dimitrakopoulou, D.; Van Nieuwenhuysen, T.; Boelens, M.; Demuynck, S.; Toussaint, W.; Creytens, D.; Van Vlierberghe, P.; Vleminckx, K.
10.1101/2021.11.15.468684 — cancer biology — Posted on 2021-11-15
1923 RNA Helix Thermodynamics: The End Game
Zuber, J.; Schroeder, S. J.; Sun, H.; Turner, D. H.; Mathews, D. H.
10.1101/2021.10.16.464667 — biophysics — Posted on 2021-11-15
1926 Bacteria but not fungi communities differ among perennial grassland ecotypic rhizosphere under abiotic environmental stress
Sarkar, S.; Kamke, A.; Ward, K.; Ran, Q.; Feehan, B.; Thapa, S.; Anderson, L.; Galliart, M.; Jumpponen, A.; Johnson, L.; Lee, S. T. M.
10.1101/2021.11.15.468685 — bioinformatics — Posted on 2021-11-15
1928 Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota
Jaunet-Lahary, T.; Shimamura, T.; Hayashi, M.; Nomura, N.; Hirasawa, K.; Shimizu, T.; Yamashita, M.; Kojima, K.; Sudo, Y.; Tamura, T.; Iwanari, H.; Hamakubo, T.; Iwata, S.; Okazaki, K.-i.; Hirai, T.; Yamashita, A.
10.1101/2021.11.15.468502 — biochemistry — Posted on 2021-11-15
1929 Structure of the Quenched Cyanobacterial OCP-Phycobilisome Complex
Dominguez-Martin, M. A.; Sauer, P. V.; Sutter, M.; Kirst, H.; Bina, D.; Greber, B. J.; Nogales, E.; Polivka, T.; Kerfeld, C. A.
10.1101/2021.11.15.468719 — biochemistry — Posted on 2021-11-15
1930 A Cryptic K48 Ubiquitin Chain Binding Site on UCH37 is Required for its Role in Proteasomal Degradation
Du, J.; Babik, S.; Li, Y.; Deol, K. K.; Eyles, S. J.; Fejzo, J.; Tonelli, M.; Strieter, E.
10.1101/2021.11.15.468727 — biochemistry — Posted on 2021-11-15
1931 Structure and functionality of a multimeric human COQ7:COQ9 complex
Manicki, M.; Aydin, H.; Abriata, L. A.; Overmyer, K. A.; Guerra, R. M.; Coon, J. J.; Dal Peraro, M.; Frost, A. S.; Pagliarini, D. J.
10.1101/2021.11.15.468694 — biochemistry — Posted on 2021-11-15
1932 A cryptic pocket in Ebola VP35 allosterically controls RNA binding
Cruz, M. A.; Frederick, T. E.; Mallimadugula, U. L.; Singh, S.; Vithani, N.; Zimmerman, M. I.; Porter, J. R.; Moeder, K. E.; Amarasinghe, G. K.; Bowman, G. R.
10.1101/2020.02.09.940510 — biochemistry — Posted on 2021-11-15
1933 Structures of the Cyanobacterial Phycobilisome
Sauer, P. V.; Dominguez-Martin, M. A.; Kirst, H.; Sutter, M.; Bina, D.; Greber, B. J.; Nogales, E.; Polivka, T.; Kerfeld, C. A.
10.1101/2021.11.15.468712 — biochemistry — Posted on 2021-11-15
1934 Deep learning methods for designing proteins scaffolding functional sites
Wang, J.; Lisanza, S.; Juergens, D.; Tischer, D.; Anishchenko, I.; Baek, M.; Watson, J. L.; Chun, J.-H.; Milles, L. F.; Dauparas, J.; Exposit, M.; Yang, W.; Saragovi, A.; Ovchinnikov, S.; Baker, D.
10.1101/2021.11.10.468128 — biochemistry — Posted on 2021-11-15
1938 Bacteriophage cocktails displayed protective effects against soft rot-causing Pectobacterium sp.
Parena, A. J. S.; Silva, B. B. I.; Mercado, R. M. L.; Sendon, A. A. A.; Signabon, F. B.; Balidion, J. F.; Encabo, J. R.
10.1101/2021.11.15.468558 — microbiology — Posted on 2021-11-15
1939 Cryptococcus neoformans capsule regrowth experiments reveal dynamics of enlargement and architecture
Wear, M. P.; Jacobs, E.; Wang, S.; McConnell, S.; Bowen, A.; Strother, C.; Cordero, R. J.; Casadevall, A.
10.1101/2021.11.15.468433 — microbiology — Posted on 2021-11-15
1941 Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Aung, A.; Cui, A.; Soleimany, A. P.; Bukenya, M.; Lee, H.; Cottrell, C. A.; Silva, M.; Kirkpatrick, J. D.; Amlashi, P.; Remba, T. K.; Xiao, S.; Froehle, L. M.; Abraham, W.; Adams, J.; Suh, H.; Huyett, P.; Kwon, D. S.; Hacohen, N.; Schief, W. R.; Bhatia, S. N.; Irvine, D. J.
10.1101/2021.11.15.468669 — immunology — Posted on 2021-11-15
1943 A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection
Chen, J.; Wang, P.; Yuan, L.; Zhang, L.; Zhang, L.; Zhao, H.; Chen, C.; Chen, Y.; Han, J.; Jia, J.; Lu, Z.; Hong, J.; Chen, L.; Fan, C.; Lu, Z.; Wang, Q.; Chen, R.; Cai, M.; Qi, R.; Wang, X.; Ma, J.; Zhou, M.; Yu, H.; Zhuang, C.; Liu, X.; Han, Q.; Wang, G.; Su, Y.; Yuan, Q.; Cheng, T.; Wu, T.; Ye, X.; Li, C.; Zhang, T.; Zhang, J.; Zhu, H.; Chen, Y.; Chen, H.; Xia, N.
10.1101/2021.11.13.468472 — pathology — Posted on 2021-11-15
1945 Deep embedding and alignment of protein sequences
Llinares-Lopez, F.; Berthet, Q.; Blondel, M.; Teboul, O.; Vert, J.-P.
10.1101/2021.11.15.468653 — bioinformatics — Posted on 2021-11-15
1946 Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
Hameedi, M. A.; Teixeira Prates, E.; Garvin, M. R.; Mathews, I.; Amos, B. K.; Demerdash, O.; Bechthold, M.; Iyer, M.; Rahighi, S.; Kneller, D. W.; Kovalevsky, A.; Irle, S.; Vuong, V.-Q.; Mitchell, J. C.; Labbe, A.; Galanie, S.; Wakatsuki, S.; Jacobson, D.
10.1101/2021.11.11.468228 — molecular biology — Posted on 2021-11-15
1947 Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2
Chen, I.; Longbotham, J. E.; McMahon, S.; Suryawanshi, R.; Carlson-Stevermer, J.; Gupta, M.; Zhang, M. Y.; Soveg, F. W.; Hayashi, J. M.; Taha, T. Y.; Lam, V. L.; Li, Y.; Yu, Z.; Titus, E. W.; Diallo, A.; Oki, J.; Holden, K.; QCRG Structural Biology Consortium, ; Krogan, N. J.; Fijimori, D. G.; Ott, M.
10.1101/2021.11.14.468537 — molecular biology — Posted on 2021-11-15
1948 Full protection against all four SARS-CoV-2 variants of concern (VOC) in hamsters requires revision of spike antigen used for vaccination.
Sharma, S.; Vercruysse, T.; Sanchez-Felipe, L.; Kerstens, W.; Abdelnabi, R.; Foo, C. S.; Lemmens, V.; Van Looveren, D.; Maes, P.; Baele, G.; Weynand, B.; Lemey, P.; Neyts, J.; Thibaut, H. J.; Dallmeier, K.
10.1101/2021.11.12.468374 — microbiology — Posted on 2021-11-15
1950 #COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol
Dommer, A.; Casalino, L.; Kearns, F.; Rosenfeld, M.; Wauer, N.; Ahn, S.-H.; Russo, J.; Oliveira, S.; Morris, C.; Bogetti, A.; Trifan, A.; Brace, A.; Sztain, T.; Clyde, A.; Ma, H.; Chennubhotla, C.; Lee, H.; Turilli, M.; Khalid, S.; Tamayo-Mendoza, T.; Welborn, M.; Christiansen, A.; Smith, D. G. A.; Qiao, Z.; Sirumalla, S. K.; O'Connor, M.; Manby, F.; Anandkumar, A.; Hardy, D.; Phillips, J.; Stern, A.; Romero, J.; Clark, D.; Dorrell, M.; Maiden, T.; Huang, L.; McCalpin, J.; Woods, C.; Gray, A.; Williams, M.; Barker, B.; Rajapaksha, H.; Pitts, R.; Gibbs, T.; Stone, J.; Zuckerman, D.; Muholland,
10.1101/2021.11.12.468428 — biophysics — Posted on 2021-11-15
1952 Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
Aznaourova, M.; Schmerer, N.; Janga, H.; Zhang, Z.; Pauck, K.; Hoppe, J.; Volkers, S. M.; Wendisch, D.; Georg, P.; Guendisch, M.; Mack, E.; Skevaki, C.; Keller, C.; Bauer, C.; Bertrams, W.; Nist, A.; Stiewe, T.; Gruber, A. D.; Ruppert, C.; Li, Y.; Garn, H.; Sander, L. E.; Schmeck, B.; Schulte, L. N.
10.1101/2021.11.05.467458 — immunology — Posted on 2021-11-15
1953 Hypoxia classifier for transcriptome datasets
Puente-Santamaria, L.; Sanchez-Gonzalez, L.; Ramos-Ruiz, R.; del Peso, L.
10.1101/2021.11.15.468572 — bioinformatics — Posted on 2021-11-15
1955 Genome-wide H3K9 Acetylation Level Increases with Age-Dependent Senescence of Flag Leaf in Rice (Oryza sativa)
Zhang, Y.; Li, Y.; Zhang, Y.; Zhang, Z.; Zhang, D.; Wang, X.; Lai, B.; Huang, D.; Gu, L.; Xie, Y.; Miao, Y.
10.1101/2021.11.14.468555 — plant biology — Posted on 2021-11-15
1958 Non-conventional serine protease activity of the CXC chemokine-cleaving streptococcal enzyme, SpyCEP
Pearson, M.; Haslam, C.; Fosberry, A.; Jones, E. J.; Reglinski, M.; Edwards, R. J.; Lawrenson, R. A.; Mossakowska, D.; Pease, J. E.; Sriskandan, S.
10.1101/2021.11.14.468564 — microbiology — Posted on 2021-11-15
1960 Shade suppresses wound-induced leaf repositioning through a mechanism involving PHYTOCHROME KINASE SUBSTRATE (PKS) genes
Fiorucci, A.-S.; Michaud, O.; Schmid-Siegert, E.; Trevisan, M.; Allenbach Petrolati, L.; Ince, Y. C.; Fankhauser, C.
10.1101/2021.11.14.468560 — plant biology — Posted on 2021-11-15
1964 Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts.
Tomofuji, K.; Fukumitsu, K.; Kondo, J.; Horie, H.; Makino, K.; Wakama, S.; Ito, T.; Oshima, Y.; Ogiso, S.; Ishii, T.; Inoue, M.; Hatano, E.
10.1101/2021.11.14.468338 — bioengineering — Posted on 2021-11-15
1967 Movement ecology of vulnerable lowland tapirs across a gradient of human disturbance
Medici, E. P.; Mezzini, S.; Fleming, C. H.; Calabrese, J.; Noonan, M. J.
10.1101/2021.11.12.468362 — ecology — Posted on 2021-11-15
1971 Rapid reconstruction of neural circuits using tissue expansion and lattice light sheet microscopy
Lillvis, J. L.; Otsuna, H.; Ding, X.; Pisarev, I.; Kawase, T.; Colonell, J.; Rokicki, K.; Goina, C.; Gao, R.; Hu, A.; Wang, K.; Bogovic, J.; Milkie, D. E.; Meienberg, L.; Boyden, E. S.; Saalfeld, S.; Tillberg, P.; Dickson, B. J.
10.1101/2021.11.14.468535 — neuroscience — Posted on 2021-11-15
1979 Deep Learning-based Automated Rare Sperm Identification from Testes Biopsies
Lee, R.; Witherspoon, L.; Robinson, M.; Lee, J. H.; Duffy, S. P.; Flannigan, R.; Ma, H.
10.1101/2021.11.14.468543 — bioengineering — Posted on 2021-11-15
1983 Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala
Sydnor, V. J.; Cieslak, M.; Duprat, R.; Deluisi, J.; Flounders, M. W.; Long, H.; Scully, M.; Balderston, N. L.; Sheline, Y. I.; Bassett, D. S.; Satterthwaite, T. D.; Oathes, D. J.
10.1101/2021.11.12.468411 — neuroscience — Posted on 2021-11-15
1986 Demogenomic modeling of the timing and the processesof early European farmers differentiation
Marchi, N.; Winkelbach, L.; Schulz, I.; Brami, M.; Hofmanova, Z.; Blocher, J.; Reyna-Blanco, C. S.; Diekmann, Y.; Thiery, A.; Kapopoulou, A.; Link, V.; Piuz, V.; Kreutzer, S.; Figarska, S. M.; Ganiatsou, E.; Pukaj, A.; Struck, T. J.; Gutenkunst, R. N.; Karul, N.; Gerritsen, F.; Pechtl, J.; Peters, J.; Zeeb-Lanz, A.; Lenneis, E.; Teschler-Nicola, M.; Triantaphyllou, S.; Stefanovi, S.; Papageorgopoulou, C.; Wegmann, D.; Burger, J.; Excoffier, L.
10.1101/2020.11.23.394502 — evolutionary biology — Posted on 2021-11-15
1987 The pace of modern life, revisited
Sanderson, S.; Beausoleil, M.-O.; O'dea, R. E.; Wood, Z. T.; Correa, C.; Frankel, V.; Gorne, L. D.; Haines, G. E.; Kinnison, M. T.; Oke, K. B.; Pelletier, F.; Perez-Jvostov, F.; Reyes-Corral, W. D.; Ritchot, Y.; Sorbara, F.; Gotanda, K. M.; Hendry, A. P.
10.1101/2021.07.30.454364 — evolutionary biology — Posted on 2021-11-15
1989 Towards optimization of oscillatory stimulation during sleep
Ladenbauer, J.; Khakimova, L.; Malinowski, R.; Obst, D.; Tonnies, E.; Antonenko, D.; Obermayer, K.; Hanna, J.; Floel, A.
10.1101/2021.09.27.461932 — neuroscience — Posted on 2021-11-15
1995 Quantitative analysis of tumour spheroid structure
Browning, A. P.; Sharp, J. A.; Murphy, R. J.; Gunasingh, G.; Lawson, B.; Burrage, K.; Haass, N. K.; Simpson, M. J.
10.1101/2021.08.05.455334 — cancer biology — Posted on 2021-11-15
1996 Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions
Wenta, T.; Schmidt, A.; Zhang, Q.; Devarajan, R.; Singh, P.; Yang, X.; Ahtikoski, A.; Vaarala, M. H.; Wei, G.-H.; Manninen, A.
10.1101/2021.11.08.467671 — cancer biology — Posted on 2021-11-15
1998 Improvement of eukaryotic proteins prediction from soil metagenomes
Belliardo, C.; Koutsovoulos, G.; Rancurel, C.; Clement, M.; Lipuma, J.; Bailly-Bechet, M.; Danchin, E. G. J.
10.1101/2021.11.10.468086 — genomics — Posted on 2021-11-15
1999 Discovery of an unusual high number of de novo mutations in sperm of older men using duplex sequencing
Salazar, R.; Arbeithuber, B.; Ivankovic, M.; Heinzl, M.; Moura, S.; Hartl, I.; Mair, T.; Heissl, A.; Ebner, T.; Shebl, O.; Proell, J.; Tiemann-Boege, I.
10.1101/2021.04.26.441422 — genetics — Posted on 2021-11-15
2000 A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations
Sturm, G.; Monzel, A. S.; Karan, K. R.; Michelson, J.; Ware, S. A.; Cardenas, A.; Lin, J.; Bris, C.; Santhanam, B.; Murphy, M. P.; Levine, M. E.; Horvath, S.; Belsky, D. W.; Wang, S.; Procaccio, V.; Kaufman, B. A.; Hirano, M.; Picard, M.
10.1101/2021.11.12.468448 — cell biology — Posted on 2021-11-15
2003 Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers
Yamano, S.; Takeda, T.; Goto, Y.; Hirai, S.; Furukawa, Y.; Kikuchi, Y.; Misumi, K.; Suzuki, M.; Takanobu, K.; Senoh, H.; Saito, M.; Kondo, H.; Kobashi, Y.; Okamoto, K.; Kishimoto, T.; Umeda, Y.
10.1101/2021.11.13.468475 — pharmacology and toxicology — Posted on 2021-11-14
2006 Global landscape of replicative DNA polymerase usage in the human genome
Koyanagi, E.; Kakimoto, Y.; Yoshifuji, F.; Natsume, T.; Higashitani, A.; Ogi, T.; Carr, A. M.; Kanemaki, M. T.; Daigaku, Y.
10.1101/2021.11.14.468503 — molecular biology — Posted on 2021-11-14
2008 Semaphorin signaling restricts neuronal regeneration in C. elegans
Harreguy, M. B.; Shah, E.; Tanvir, Z.; Simprevil, B.; Tran, T. S.; Haspel, G.
10.1101/2021.11.13.468479 — neuroscience — Posted on 2021-11-14
2010 Microfluidic system-based time-course tracking of physical proximity between cells and its effect on gene expression for elucidating live single cancer-immune cell interactions
Flores, B. C. T.; Chawla, S.; Ma, N.; Sanada, C.; Kujur, P. K.; Chinen, L. T. D.; Hukari, K.; Lynch, M.; Ramalingam, N.; Sengupta, D.; Jeffrey, S. S.
10.1101/2021.11.13.468447 — cancer biology — Posted on 2021-11-14
2017 Genomic evidence of paternal genome elimination in globular springtails
Jaron, K. S.; Hodson, C. N.; Ellers, J.; Baird, S. J. E.; Ross, L.
10.1101/2021.11.12.468426 — genomics — Posted on 2021-11-14
2018 Cellular and transcriptional diversity over the course of human lactation
Nyquist, S. K.; Gao, P.; Haining, T. K. J.; Retchin, M. R.; Golan Maor, Y.; Drake, R. S.; Kolb, K.; Mead, B. E.; Ahituv, N.; Martinez, M. E.; Berger, B.; Shalek, A. K.; Goods, B. A.
10.1101/2021.11.13.468496 — genomics — Posted on 2021-11-14
2019 Formal meta-analysis of hypoxic gene expression profiles reveals a universal gene signature and cell type-specific effects
Puente-Santamaria, L.; Sanchez-Gonzalez, L.; Gonzalez-Serrano, B. P.; Pescador, N.; Martinez-Costa, O. H.; Ramos-Ruiz, R.; del Peso, L.
10.1101/2021.11.12.468418 — genomics — Posted on 2021-11-14
2022 Investigating Increased CO2 concentration on the pH of various plant species
Schafer, J.; Puga, T.; Harris, P.; Strasser, N.; Branum, G.; Agbedanu, P. N.
10.1101/2021.11.13.468474 — ecology — Posted on 2021-11-14
2023 Aerobic Bacteria Produce Nitric Oxide via Denitrification and Trigger Algal Population Collapse
Abada, A.; Sperfeld, M.; Carmieli, R.; Ben-Dor, S.; Huang Zhang, I.; Babbin, A. R.; Segev, E.
10.1101/2021.11.14.468512 — microbiology — Posted on 2021-11-14
2024 CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B1 cells in the bone marrow
Elias, S.; Sharma, R.; Schizas, M.; Valdez, I.; Park, S.-M.; Gonzalez-Figueroa, P.; Li, Q.-Z.; Hoyos, B.; Rudensky, A. Y.
10.1101/2021.11.14.468515 — immunology — Posted on 2021-11-14
2025 Defining Innate Immune Responses to the Human Gut Microbiota from Phylum to Strain
Spindler, M. P.; Siu, S. S.; Mogno, I.; Li, Z.; Yang, C.; Mehandru, S.; Britton, G. J.; Faith, J. J.
10.1101/2021.11.13.468498 — immunology — Posted on 2021-11-14
2027 Fluorescent and bioluminescent calcium indicators with tuneable colors and affinities
Mertes, N.; Busch, M.; Huppertz, M.-C.; Hacker, C. N.; Guerth, C.-M.; Kuehn, S.; Hiblot, J.; Koch, B.; Johnsson, K.
10.1101/2021.11.13.468356 — neuroscience — Posted on 2021-11-14
2030 Polymer skulls with integrated transparent electrode arrays for cortex-wide opto-electrophysiological recordings
Donaldson, P. D.; Navabi, Z. S.; Carter, R. E.; Fausner, S. M. L.; Ghanbari, L.; Ebner, T. J.; Swisher, S. L.; kodandaramaiah, S. B.
10.1101/2021.11.13.468490 — neuroscience — Posted on 2021-11-14
2032 Initiation of organ maturation and fruit ripening in grapevine is controlled by the CARPO-NAC transcription factor
D'Inca, E.; Foresti, C.; Orduna, L.; Amato, A.; Vandelle, E.; Santiago, A.; Botton, A.; Cazzaniga, S.; Bertini, E.; Pezzotti, M.; Giovannoni, J.; Vrebalov, J.; Matus, J. T.; Tornielli, G. B.; Zenoni, S.
10.1101/2021.11.13.468481 — plant biology — Posted on 2021-11-14
2033 Mechanism of glycogen synthase inactivation and interaction with glycogenin
Marr, L.; Biswas, D.; Daly, L. A.; Browning, C.; Pollard, J.; Hudson, C.; Bertrand, J.; Ranson, N. A.; Khatter, H.; Eyers, C. E.; Sakamoto, K.; Zeqiraj, E.
10.1101/2021.11.14.468517 — biochemistry — Posted on 2021-11-14
2037 Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits
Sasmal, A.; Khan, N.; Khedri, Z.; Kellman, B. P.; Srivastava, S.; Verhagen, A.; Yu, H.; Bruntse, A. B.; Diaz, S.; Varki, N.; Beddoe, T.; Paton, A. W.; Paton, J. C.; Chen, X.; Lewis, N. E.; Varki, A.
10.1101/2021.05.28.446191 — microbiology — Posted on 2021-11-14
2038 Maternal microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice
Lopez-Tello, J.; Schofield, Z.; Kiu, R.; Dalby, M. J.; van Sinderen, D.; Le Gall, G.; Sferruzzi-Perri, A. N.; Hall, L. J.
10.1101/2021.07.23.453407 — physiology — Posted on 2021-11-14
2041 RNA splicing analysis using heterogeneous and large RNA-seq datasets
Vaquero-Garcia, J.; Aicher, J. K.; Jewell, P.; Gazzara, M. R.; Radens, C. M.; Jha, A.; Green, C. J.; Norton, S. S.; Lahens, N. F.; Grant, G. R.; Barash, Y.
10.1101/2021.11.03.467086 — bioinformatics — Posted on 2021-11-14
2044 Diversification of Transcription Factor NF-κB in Protists
Williams, L. M.; Sridhar, S.; Samaroo, J.; Adindu, E. K.; Addanki, A.; BB522 Molecular Biology Laboratory, ; Aguirre Carrion, P. J.; DiRusso, C. J.; Rodriguez-Sastre, N.; Siggers, T.; Gilmore, T. D.
10.1101/2021.03.15.435342 — cell biology — Posted on 2021-11-14
2047 An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport
Gaspar, I.; Phea, L. J.; McClintock, M. A.; Heber, S.; Bullock, S. L.; Ephrussi, A.
10.1101/2021.04.24.441269 — cell biology — Posted on 2021-11-14
2051 Vγ usage distinguishes pro- and anti-tumor intestinal γδ T cell subsets
Reis, B. S.; Darcy, P. W.; Khan, I. Z.; Eleso, O.; Zhu, C.; Schernthanner, M.; Lockhart, A.; Reed, A.; Bortolatto, J.; Castro, T.; Bilate, A.; Grivennikov, S.; Mucida, D.
10.1101/2021.11.13.468487 — immunology — Posted on 2021-11-13
2052 Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans
Pamplona, F. A.; Vitoria, G.; Ribeiro, F. C.; Moraes, C. A.; Ledur, P. F.; Karmirian, K.; Ornelas, I. M.; Leo, L. M.; Paulsen, B.; Sudo, F. K.; Coutinho, G.; Drummond, C.; Assuncao, N.; Vanderborght, B.; Canetti, C.; Castro-Faria-Neto, H. C.; Mattos, P.; Ferreira, S. T.; Rehen, S. K.; Bozza, F. A.; Lourenco, M. V.; Tovar-Moll, F.
10.1101/2021.11.12.468379 — neuroscience — Posted on 2021-11-13
2053 Brain simulation augments machine-learning-based classification of dementia
Triebkorn, P.; Stefanovski, L.; Dhindsa, K.; Diaz-Cortes, M.-A.; Bey, P.; Bülau, K.; Pai, R. K.; Spiegler, A.; Solodkin, A.; Jirsa, V.; McIntosh, R.; Alzheimer's Disease Neuroimaging Initiative, ; Ritter, P.
10.1101/2021.02.27.433161 — neuroscience — Posted on 2021-11-13
2057 Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells
Webber, B. R.; Johnson, M. J.; Slipek, N. S.; Lahr, W. S.; DeFeo, A. P.; Skeate, J. G.; Qiu, X.; Rathmann, B.; Diers, M. D.; Wick, B.; Henley, T.; Choudhry, M.; McIvor, R. S.; Moriarity, B. S.
10.1101/2021.11.12.468427 — bioengineering — Posted on 2021-11-13
2059 Siderophores as an iron source for Prochlorococcus in deep chlorophyll maximum layers of the oligotrophic ocean
Hogle, S. L.; Hackl, T.; Bundy, R. M.; Park, J.; Satinsky, B.; Hiltunen, T.; Biller, S.; Berube, P. M.; Chisholm, S. W.
10.1101/2021.11.13.468467 — ecology — Posted on 2021-11-13
2060 Poly ADP-ribosylation of SET8 leads to aberrant H4K20me1 domains in mammalian cells
Esteve, P.-O.; Udayakumaran Nair Sunitha Kumary, V.; Ruse, C.; Chin, H. G.; Pradhan, S.
10.1101/2021.11.13.468478 — molecular biology — Posted on 2021-11-13
2061 The Transcriptome Architecture of Polyomaviruses
Nomburg, J.; Zou, W.; Frost, T. C.; Datta, C.; Vasudevan, S.; Starrett, G. J.; Imperiale, M. J.; Meyerson, M.; DeCaprio, J. A.
10.1101/2021.11.12.468421 — microbiology — Posted on 2021-11-13
2065 Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex
Huang, G.; Zhan, X.; Zeng, C.; Liang, K.; Zhu, X.; Zhao, Y.; Wang, P.; Wang, Q.; Zhou, Q.; Tao, Q.; Liu, M.; Lei, J.; Yan, C.; Shi, Y.
10.1101/2021.11.13.468242 — biophysics — Posted on 2021-11-13
2072 A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations
Sturm, G.; Monzel, A. S.; Karan, K. R.; Michelson, J.; Ware, S. A.; Cardenas, A.; Lin, J.; Bris, C.; Santhanam, B.; Murphy, M. P.; Levine, M. E.; Horvath, S.; Belsky, D. W.; Wang, S.; Procaccio, V.; Kaufman, B. A.; Hirano, M.; Picard, M.
10.1101/2021.11.12.468448 — cell biology — Posted on 2021-11-13
2076 Ferric Citrate Uptake is a Virulence Factor in Uropathogenic Escherichia coli
Frick-Cheng, A. E.; Sintsova, A.; Smith, S. N.; Pirani, A.; Snitkin, E. S.; Mobley, H. L. T.
10.1101/2021.11.12.468464 — microbiology — Posted on 2021-11-13
2078 Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles
Specht, C.; Homan, E. J.; Lee, C. K.; Mou, Z.; Gomez, C. L.; Hester, M. M.; Abraham, A.; Rus, F.; Ostroff, G.; Levitz, S. M.
10.1101/2021.11.12.468465 — immunology — Posted on 2021-11-13
2083 Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
McCorvie, T. J.; Loria, P. M.; Tu, M.; Han, S.; Shrestha, L.; Froese, D. S.; Ferreira, I. M.; Berg, A. P.; Yue, W. W.
10.1101/2021.11.12.468446 — biochemistry — Posted on 2021-11-13
2085 The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of Clostridioides difficile and commensal Clostridia
Theriot, C. M.; Reed, A. D.; Fletcher, J. R.; Huang, Y.; Thanissery, R.; Rivera, A. M.; Parsons, R. J.; Stewart, A.; Kountz, D. J.; Shen, A.; Balskus, E. P.
10.1101/2021.11.12.468462 — microbiology — Posted on 2021-11-13
2088 Maternal diet disrupts the placenta-brain axis in a sex-specific manner
Ceasrine, A. M.; Devlin, B. A.; Bolton, J. L.; Jo, Y. C.; Huynh, C.; Patrick, B.; Washington, K.; Joo, F.; Campos-Salazar, A. B.; Lockshin, E. R.; Murphy, S. K.; Simmons, L. A.; Bilbo, S. D.
10.1101/2021.11.12.468408 — neuroscience — Posted on 2021-11-13
2091 Determinants of precocious B-cell aging in European adolescences living with perinatally acquired HIV-1 after over 10 years of suppressive therapy
Ruggiero, A.; Pascucci, G. R.; Cotugno, N.; Dominguez-Rodriguez, S.; Stefano, R.; Tagarro Garcia, A.; Rojo, P.; Foster, C.; Bamford, A.; De Rossi, A.; Nastouli, E.; Nigel, K.; Elena, M.; Fatou, B.; Smolen, K. K.; Ozonoff, A.; Katherine, L.; Steen, H.; Carlo, G.; Goulder, P.; Rossi, P.; Levy, O.; Pahwa, S.; Palma, P.; included in the manuscript,
10.1101/2021.11.11.468189 — immunology — Posted on 2021-11-13
2093 The BCM rule allows a spinal cord model to learn rhythmic movements
Kohler, M.; Stratmann, P.; Roehrbein, F.; Knoll, A.; Albu-Schaeffer, A.; Jorntell, H.
10.1101/2021.11.12.467473 — neuroscience — Posted on 2021-11-13
2097 Genetic regulation of RNA splicing in human pancreatic islets
Atla, G.; Bonas-Guarch, S.; Cuenca, M.; Beucher, A.; Garcia-Hurtado, J.; Moran, I.; Irimia, M.; Prasad, R. B.; Gloyn, A. L.; Marselli, l.; Suleiman, M.; Berney, T.; de Koning, E. J. P.; Kerr-Conte, J.; Pattou, F.; Piemonti, L.; Ferrer, J.
10.1101/2021.11.11.468254 — genetics — Posted on 2021-11-13
2103 Therapeutic Deep Brain Stimulation Disrupts Subthalamic Nucleus Activity Dynamics in Parkinsonian Mice
Schor, J. S.; Gonzalez Montalvo, I.; Spratt, P. W. E.; Brakaj, R. J.; Stansil, J. A.; Bender, K. J.; Nelson, A. B.
10.1101/2021.11.12.468404 — neuroscience — Posted on 2021-11-13
2114 Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation
Jeong, H.; Grimes, K.; Bruch, P.-M.; Rausch, T.; Hasenfeld, P.; Sabarinathan, R.; Porubsky, D.; Herbst, S. A.; Erarslan-Uysal, B.; Jann, J.-C.; Marschall, T.; Nowak, D.; Bourquin, J.-P.; Kulozik, A. E.; Dietrich, S.; Bornhauser, B.; Sanders, A. D.; Korbel, J. O.
10.1101/2021.11.11.468039 — genomics — Posted on 2021-11-13
2117 Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis
Maity, S.; Chakraborty, A.; Mahata, S. K.; Roy, S.; Das, A. K.; Sen, M.
10.1101/2021.11.12.468361 — immunology — Posted on 2021-11-13
2118 Zika virus infection during development impairs the formation of corpus callosum by disturbing axon guidance and growth of callosal neurons.
Christoff, R. R.; Quintanilha, J. H.; Ferreira, R. O.; Ferreira, J. C. C. G.; Guimaraes, D. M.; Valerio-Gomes, B.; Higa, L. M.; Rossi, A. D.; Vasconcelos, J. M.; Vianez, J. L. S. G.; Bellio, M.; Tanuri, A.; Lent, R.; Garcez, P. P.
10.1101/2021.11.11.468315 — neuroscience — Posted on 2021-11-13
2122 Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the lifespan
WU, S.; TYLER, L. K.; Henson, R. N.; Rowe, J.; Cambridge Centre for Ageing and Neuroscience (Cam-CAN), ; Tsvetanov, K. A.
10.1101/2021.11.10.468042 — neuroscience — Posted on 2021-11-13
2123 Integrated resource for functional and structural connectivity of the marmoset brain
Tian, X.; Chen, Y.; Majka, P.; Szczupak, D.; Sanz-Perl, Y.; Yen, C. C.-C.; Tong, C.; Song, K.; Jiang, H.; Glen, D.; Deco, G.; Rosa, M. G. P.; Silva, A. C.; Liang, Z.; Liu, C.
10.1101/2021.11.12.468389 — neuroscience — Posted on 2021-11-13
2124 Real-time Image Denoising of Mixed Poisson-Gaussian Noise in Fluorescence Microscopy Images using ImageJ
Mannam, V.; Zhang, Y.; Zhu, Y.; Nichols, E.; Wang, Q.; Sundaresan, V.; Zhang, S.; Smith, C.; Bohn, P. W.; Howard, S.
10.1101/2021.11.10.468102 — neuroscience — Posted on 2021-11-13
2125 Microglial phagocytosis dysfunction during stroke is prevented by rapamycin
Beccari, S.; Sierra-Torre, V.; Valero, J.; Garcia-Zaballa, M.; Carretero-Guillen, A.; Capetillo-Zarate, E.; Domercq, M.; Huguet, P.; Ramonet, D.; Osman, A.; Han, W.; Dominguez, C.; Faust, T. E.; Touzani, O.; Boya, P.; Schafer, D.; Marino, G.; Canet-Soulas, E.; Blomgren, K.; Plaza-Zabala, A.; Sierra, A.
10.1101/2021.11.12.468358 — neuroscience — Posted on 2021-11-13
2126 Genomic hallmarks of cellular dormancy in cancer and therapeutic implications
Wiecek, A. J.; Cutty, S. J.; Kornai, D.; Parreno-Centeno, M.; Gourmet, L. E.; Malagoli Tagliazucchi, G.; Jacobson, D. H.; Zhang, P.; Xiong, L.; Bond, G. L.; Barr, A. R.; Secrier, M.
10.1101/2021.11.12.468410 — cancer biology — Posted on 2021-11-13
2127 Identification and Characterization of Long Non-Coding RNA in Tomato Roots under Salt Stress
Li, N.; Wang, Z.; Wang, B.; Wang, J.; Xu, R.; Yang, T.; Huang, S.; Yu, Q.; Wang, H.; Gao, J.
10.1101/2021.11.12.468377 — bioinformatics — Posted on 2021-11-13
2129 The Xenopus Phenotype Ontology: bridging model organism phenotype data to human health and development.
Fisher, M. E.; Segerdell, E. J.; Matentzoglu, N.; Nenni, M. J.; Fortriede, J. D.; Chu, S.; Pells, T.; Chaturvedi, P.; James-Zorn, C.; Sundararaj, N.; Lotay, V.; Ponferrada, V.; Wang, D. Z.; Kim, E.; Agalakov, S.; Arshinoff, B. I.; Karimi, K.; Vize, P. D.; Zorn, A. M.
10.1101/2021.11.12.467727 — bioinformatics — Posted on 2021-11-13
2136 A Multigraph model of the 3D genome
Makai, D.; Cseh, A.; Sepsi, A.; Makai, S.
10.1101/2021.11.11.468281 — genomics — Posted on 2021-11-13
2138 An optimized ChIP-Seq framework for profiling of histone modifications in Chromochloris zofingiensis
Strenkert, D.; Mingay, M.; Schmollinger, S.; Chen, C.; O'Malley, R. C.; Merchant, S. S.
10.1101/2021.11.11.468265 — genomics — Posted on 2021-11-13
2143 Biocatalytic quantification of α-glucan in particulate marine organic matter
Steinke, N.; Vidal-Melgosa, S.; Schultz-Johansen, M.; Hehemann, J.-H.
10.1101/2021.11.10.468175 — ecology — Posted on 2021-11-13
2144 Data-Poor Ecological Risk Assessment of Multiple Stressors
Grewelle, R. E.; Mansfield, E.; Micheli, F.; De Leo, G. A.
10.1101/2021.11.11.468297 — ecology — Posted on 2021-11-13
2145 T cells discriminate between groups C1 and C2 HLA-C
Sim, M. J. W.; Stotz, Z.; Lu, J.; Brennan, P.; Long, E. O.; Sun, P. D.
10.1101/2021.11.11.468262 — immunology — Posted on 2021-11-13
2146 Subiculum - BNST Structural Connectivity in Humans and Macaques
Berry, S. C.; Lawrence, A. D.; Lancaster, T. M.; Casella, C. M.; Aggleton, J. P.; Postans, M.
10.1101/2021.11.11.468209 — neuroscience — Posted on 2021-11-13
2149 Structural brain connectivity predicts acute pain after mild traumatic brain injury
Branco, P.; Bosak, N.; Bielefeld, J.; Cong, O.; Granovsky, Y.; Kahn, I.; Yarnitsky, D.; Apkarian, A. V.
10.1101/2021.11.12.468345 — neuroscience — Posted on 2021-11-13
2152 A dynamic clamp protocol to artificially modify cell capacitance
Pfeiffer, P.; Tomas, F. J. B.; Wu, J.; Schleimer, J.-H.; Vida, I.; Schreiber, S.
10.1101/2021.11.12.468368 — neuroscience — Posted on 2021-11-13
2158 A Landmark-based Common Coordinate Framework for Spatial Transcriptomics Data
Andersson, A.; Andrusivova, Z.; Czarnewski, P.; Li, X.; Sundström, E.; Lundeberg, J.
10.1101/2021.11.11.468178 — bioinformatics — Posted on 2021-11-13
2160 High-sensitivity pattern discovery in large, paired multi-omic datasets
Ghazi, A. R.; Sucipto, K.; Rahnavard, G.; Franzosa, E. A.; McIver, L. J.; Lloyd-Price, J.; Schwager, E.; Weingart, G.; Moon, Y. S.; Morgan, X. C.; Waldron, L.; Huttenhower, C.
10.1101/2021.11.11.468183 — bioinformatics — Posted on 2021-11-13
2161 Interactive Analysis of Biosurfactants in Fruit-Waste Fermentation Samples using BioSurfDB and MEGAN
Silva, G. F.; Gautam, A.; Duarte, I. C. S.; Delforno, T. P.; Oliveira, V. M.; Huson, D.
10.1101/2021.11.11.468240 — bioinformatics — Posted on 2021-11-13
2163 FEASIBILITY OF VASCULAR REMODELING PARAMETER ESTIMATION FOR ASSESSING HYPERTENSIVE PREGNANCY DISORDERS
Kissas, G.; Hwuang, E.; Thompson, E.; Schwartz, N.; Detre, J.; Witschey, W.; Perdikaris, P.
10.1101/2021.11.10.468132 — bioengineering — Posted on 2021-11-13
2164 Autonomous treatment of bacterial infections in vivo using antimicrobial micro- and nanomachines
Arque, X.; Torres, M. D. T.; Patino, T.; Boaro, A.; Sanchez, S.; de la Fuente-Nunez, C.
10.1101/2021.11.11.468250 — bioengineering — Posted on 2021-11-13
2166 Low frequency somatic copy number alterations in normal human lymphocytes revealed by large scale single-cell whole genome profiling
Liu, L.; Chen, H.; Sun, C.; Zhang, J.; Wang, J.; Du, M.; Li, J.; Di, L.; Shen, J.; Geng, S.; Pang, Y.; Luo, Y.; Wu, C.; Fu, Y.; Zheng, Z.; Wang, J.; Huang, Y.
10.1101/2021.11.10.468149 — genomics — Posted on 2021-11-13
2167 Little heterosis found in Diploid Hybrid Potato
Adams, J. R.; Zheng, C.; de Vries, M. E.; van Eeuwijk, F. A.
10.1101/2021.11.10.468131 — genetics — Posted on 2021-11-13
2169 Real-time alerts from AI-enabled camera traps using the Iridium satellite network: a case-study in Gabon, Central Africa
Whytock, R. C.; Suijten, T.; van Deursen, T.; Swiezewski, J.; Mermiaghe, H.; Madamba, N.; Moukoumou, N.; Zwerts, J. A.; Koumba Pambo, A. F.; Bahaa-el-din, L.; Brittain, S.; Cardoso, A. W.; Henschel, P.; Lehmann, D.; Momboua, B. R.; Makaga, L.; Orbell, C.; White, L. J.; Iponga, D. M.; Abernethy, K. A.
10.1101/2021.11.10.468078 — ecology — Posted on 2021-11-13
2170 A series of terribly unfortunate events: How environment and infection synergized to cause the Kihansi spray toad extinction
Sewell, T. R.; van Dorp, L.; Ghosh, P.; Wierzbicki, C.; Caroe, C.; Lyakurwa, J. V.; Tonelli, E.; Bowkett, A.; Marsden, S.; Cunningham, A. A.; Fisher, M. C.; Garner, T. W.; Weldon, C.; Tonelli, E.
10.1101/2021.11.10.468118 — ecology — Posted on 2021-11-13
2172 Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
Papadas, A.; Deb, G.; Officer, A.; Cicala, A.; Hope, C.; Emmerich, P.; Wiesner, J.; Pagenkopf, A.; Matkowskyj, K.; Deming, D. A.; Politi, K.; Abrams, S.; Harismendy, O.; Asimakopoulos, F.
10.1101/2021.11.10.467836 — immunology — Posted on 2021-11-13
2173 Altered brain criticality in Schizophrenia: New insights from MEG
Alamian, G.; Lajnef, T.; Pascarella, A.; Lina, J.-M.; Knight, L.; Walters, J.; Singh, K. D.; Jerbi, K.
10.1101/2021.11.09.467906 — neuroscience — Posted on 2021-11-13
2176 Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Schaeffner, E.; Edgar, J.; Lehning, M.; Strauss, J.; Bosch-Queralt, M.; Wieghofer, P.; Berghoff, S. A.; Krueger, M.; Morawski, M.; Reinert, T.; Moebius, W.; Barrantes-Freer, A.; Prinz, M.; Reich, D. S.; Fluegel, A.; Stadelmann, C.; Fledrich, R.; Stassart, R. M.; Nave, K.-A.
10.1101/2021.11.11.468223 — neuroscience — Posted on 2021-11-13
2178 Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus.
Martin, M.-F.; Maarifi, G.; Abiven, H.; Seffals, M.; Mouchet, N.; Beck, C.; Bodet, C.; Leveque, N.; Arhel, N. J.; Blanchet, F. P.; Simonin, Y.; Nisole, S.
10.1101/2021.08.17.456611 — microbiology — Posted on 2021-11-13
2180 Genomic landscape of drug response reveals novel mediators of anthelmintic resistance
Doyle, S. R.; Laing, R.; Bartley, D.; Morrison, A.; Holroyd, N.; Maitland, K.; Antonopoulos, A.; Chaudhry, U.; Flis, I.; Howell, S.; McIntyre, J.; Gilleard, J. S.; Tait, A.; Mable, B. K.; Kaplan, R.; Sargison, N.; Britton, C.; Berriman, M.; Devaney, E.; Cotton, J.
10.1101/2021.11.12.465712 — genomics — Posted on 2021-11-13
2181 Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode
Laing, R.; Doyle, S. R.; McIntyre, J.; Maitland, K.; Morrison, A.; Bartley, D. J.; Kaplan, R.; Chaudhry, U.; Sargison, N.; Tait, A.; Cotton, J. A.; Britton, C.; Devaney, E.
10.1101/2021.11.12.468372 — genomics — Posted on 2021-11-13
2182 Quantifying concordant genetic effects of de novo mutations on multiple disorders
Guo, H.; Hou, L.; Shi, Y.; Jin, S. C.; Zeng, X.; Li, B.; Lifton, R.; Brueckner, M.; Zhao, H.; Lu, Q.
10.1101/2021.06.13.448234 — genetics — Posted on 2021-11-13
2188 Cortical wiring by synapse-specific control of local protein synthesis
Bernard, C.; Exposito-Alonso, D.; Selten, M.; Sanalidou, S.; Hanusz-Godoy, A.; Oozeer, F.; Maeso, P.; Rico, B.; Marin, O.
10.1101/2021.11.12.468364 — neuroscience — Posted on 2021-11-13
2189 Transcriptional regulation of neonatal neural stem cells is a determinant of social behavior
Hiramoto, T.; Boku, S.; Kang, G.; Abe, S.; Barbachan e Silva, M.; Tanigaki, K.; Nagashima, M.; Ye, K.; Yamauchi, T.; Michurina, T. V.; O Broin, P.; Enikolopov, G.; Hiroi, N.
10.1101/2021.11.12.468452 — neuroscience — Posted on 2021-11-13
2190 'Constituent length' effects in fMRI do not provide evidence for abstract syntactic processing
Shain, C.; Kean, H.; Lipkin, B.; Affourtit, J.; Siegelman, M.; Mollica, F.; Fedorenko, E.
10.1101/2021.11.12.467812 — neuroscience — Posted on 2021-11-13
2193 Genome assembly of the Australian black tiger shrimp (Penaeus monodon) reveals a fragmented IHHNV EVE sequence
Huerlimann, R.; Cowley, J. A.; Wade, N. M.; Wang, Y.; Kasinadhuni, N.; Chan, C.-K. K.; Jabbari, J.; Siemering, K.; Gordon, L.; Tinning, M.; Montenegro, J. D.; Maes, G. E.; Sellars, M. J.; Coman, G. J.; McWilliam, S.; Zenger, K. R.; Khatkar, M. S.; Raadsma, H. W.; Donovan, D.; Krishna, G.; Jerry, D.
10.1101/2021.11.11.468259 — genomics — Posted on 2021-11-12
2194 Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode
Laing, R.; Doyle, S. R.; McIntyre, J.; Maitland, K.; Morrison, A.; Bartley, D. J.; Kaplan, R.; Chaudhry, U.; Sargison, N.; Tait, A.; Cotton, J. A.; Britton, C.; Devaney, E.
10.1101/2021.11.12.468372 — genomics — Posted on 2021-11-12
2196 PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
D'Avola, A.; Legrave, N.; Tajan, M.; Chakravarty, P.; Shearer, R.; King, H.; Cheung, E.; Clear, A.; Gunawan, A.; Zhang, L.; James, L.; MacRae, J.; Gribben, J.; Calado, D.; Vousden, K.; Riches, J.
10.1101/2021.11.11.468272 — immunology — Posted on 2021-11-12
2197 Scaling between DNA and cell size governs bacterial growth homeostasis and resource allocation
Li, B.; Zhang, S.; Zhang, L.; Qiao, X.; Shi, Y.; Li, C.; Ouyang, Q.; Wei, P.; Qian, L.
10.1101/2021.11.12.468234 — systems biology — Posted on 2021-11-12
2199 Nanopore adaptive sampling for mitogenome sequencing and bloodmeal identification in hematophagous insects
Kipp, E. J.; Lindsey, L. L.; Blanco, C. M.; Baker, J.; Milstein, M. S.; Faulk, C.; Oliver, J. D.; Larsen, P. A.
10.1101/2021.11.11.468279 — genomics — Posted on 2021-11-12
2200 Pathways to polar adaptation in fishes revealed by long-read sequencing
Hotaling, S.; Desvignes, T.; Sproul, J. S.; Lins, L. S. F.; Kelley, J. L.
10.1101/2021.11.12.468413 — genomics — Posted on 2021-11-12
2201 Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin
Chan, M.; Yuan, H.; Soifer, I.; Maile, T. M.; Wang, R. Y.; Ireland, A.; O'Brien, J.; Goudeau, J.; Chan, L.; Vijay, T.; Freund, A.; Kenyon, C.; Bennett, B.; McAllister, F.; Kelley, D. R.; Roy, M.; Cohen, R. L.; Levinson, A. D.; Botstein, D.; Hendrickson, D.
10.1101/2021.05.03.442497 — genomics — Posted on 2021-11-12
2202 Population genomics reveal distinct and diverging populations of An. minimus in Cambodia - a widespread malaria vector in Southeast Asia
St. Laurent, B.; Harding, N.; Deason, N.; Oy, K.; Loeun, C. S.; Sunly, R.; Sary, M.; Nhep, S.; Drury, E.; Rockett, K.; Sovannaroth, S.; Goncalves, S.; Kwiatkowski, D.; Miles, A.
10.1101/2021.11.11.468219 — genomics — Posted on 2021-11-12
2203 MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses
Devine, J.; Vidal-Garcia, M.; Liu, W.; Neves, A.; Lo Vercio, L. D.; Green, R. M.; Richbourg, H. A.; Marchini, M.; Unger, C. M.; Nickle, A. C.; Radford, B.; Young, N. M.; Gonzalez, P. N.; Schuler, R. E.; Bugacov, A.; Rolian, C.; Percival, C. J.; Williams, T.; Niswander, L.; Calof, A. L.; Lander, A. D.; Visel, A.; Jirik, F. R.; Cheverud, J. M.; Klein, O. D.; Birnbaum, R. Y.; Merrill, A. E.; Ackermann, R. R.; Graf, D.; Hemberger, M.; Dean, W.; Forkert, N. D.; Murray, S. A.; Westerberg, H.; Marcucio, R. S.; Hallgrimsson, B.
10.1101/2021.11.11.468142 — genetics — Posted on 2021-11-12
2205 Phylogenetic diversity of two common Trypanosoma cruzi lineages in the Southwestern United States
Flores-Lopez, C. A.; Mitchell, E. A.; Reisenman, C. E.; Sarkar, S.; Williamson, P. C.; Machado, C. A.
10.1101/2021.11.10.468115 — evolutionary biology — Posted on 2021-11-12
2207 An efficient and adaptable workflow for editing disease-relevant single nucleotide variants using CRISPR/Cas9
Usher, I.; Ligammari, L.; Ahrabi, S.; Hepburn, E.; Connolly, C.; Bond, G. L.; Flanagan, A. M.; Cottone, L.
10.1101/2021.11.12.467071 — molecular biology — Posted on 2021-11-12
2208 Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays
Thakku, S. G.; Ackerman, C. M.; Myhrvold, C.; Bhattacharyya, R. P.; Livny, J.; Ma, P.; Gomez, G. I.; Sabeti, P.; Blainey, P. C.; Hung, D. T.
10.1101/2021.11.12.468388 — microbiology — Posted on 2021-11-12
2210 STAT1 Gain-of-Function Variants Drive Altered T Cell Prevalence, Metabolism, and Heightened IL-6 Sensitivity
Kaviany, S.; Bartkowiak, T.; Dulek, D. E.; Khan, Y. W.; Hayes, M. J.; Schaefer, S. K.; Dahunsi, D. O.; Connelly, J. A.; Irish, J. M.; Rathmell, J. C.
10.1101/2021.11.10.468135 — immunology — Posted on 2021-11-12
2212 Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact interactions with hosts
Ajayi, O. M.; Marlman, J. M.; Gleitz, L. A.; Smith, E. S.; Piller, B. D.; Krupa, J. A.; Vinauger, C.; Benoit, J. B.
10.1101/2021.11.11.467918 — physiology — Posted on 2021-11-12
2213 A novel non-genetic murine model of hyperglycemia and hyperlipidemia-associated accelerated atherosclerosis
Gaul, S.; Shahzad, K.; Medert, R.; Gadi, I.; Meader, C.; Schumacher, D.; Wirth, A.; Ambreen, S.; Fatima, S.; Boeckel, J.-N.; Khawaja, H.; Haas, J.; Brune, M.; Nawroth, P. P.; Isermann, B.; Laufs, U.; Freichel, M.
10.1101/2021.11.11.468191 — pharmacology and toxicology — Posted on 2021-11-12
2215 Genomic landscape of drug response reveals novel mediators of anthelmintic resistance
Doyle, S. R.; Laing, R.; Bartley, D.; Morrison, A.; Holroyd, N.; Maitland, K.; Antonopoulos, A.; Chaudhry, U.; Flis, I.; Howell, S.; McIntyre, J.; Gilleard, J. S.; Tait, A.; Mable, B. K.; Kaplan, R.; Sargison, N.; Britton, C.; Berriman, M.; Devaney, E.; Cotton, J.
10.1101/2021.11.12.465712 — genomics — Posted on 2021-11-12
2220 Regulatory T cells suppress the formation of super-effector CD8 T cells by limiting IL-2
Tsyklauri, O.; Chadimova, T.; Niederlova, V.; Kovarova, J.; Michalik, J.; Malatova, I.; Janusova, S.; Rossez, H.; Drobek, A.; Vecerova, H.; Galati, V.; Kovar, M.; Stepanek, O.
10.1101/2021.11.10.467495 — immunology — Posted on 2021-11-12
2221 A de novo matrix for macroscopic living materials from bacteria
Molinari, S.; Tesoriero, R. F.; Li, D.; Sridhar, S.; Cai, R.; Soman, J.; Ryan, K. R.; Ashby, P. D.; Ajo-Franklin, C.
10.1101/2021.11.12.468079 — synthetic biology — Posted on 2021-11-12
2223 Transcriptomic plasticity and symbiont shuffling underpin Pocillopora acclimatization across heat-stress regimes in the Pacific Ocean
Armstrong, E. J.; Le-Hoang, J.; Carradec, Q.; Aury, J.-M.; Noel, B.; Poulain, J.; Belser, C.; Da Silva, C.; Wincker, P.; Tara Pacific Consortium,
10.1101/2021.11.12.468330 — physiology — Posted on 2021-11-12
2226 Molecular basis of unidirectional information transmission in two-component systems: lessons from the DesK-DesR thermosensor
Lima, S.; Blanco, J.; Olivieri, F.; Imelio, J. A.; Carrion, F.; Alvarez, B.; Buschiazzo, A.; Marti, M.; Trajtenberg, F.
10.1101/2021.11.12.468217 — biophysics — Posted on 2021-11-12
2232 Organization of central circuits for wind-guided olfactory navigation
Matheson, A. M. M.; Lanz, A. J.; Licata, A. M.; Currier, T. A.; Syed, M. H.; Nagel, K. I.
10.1101/2021.04.21.440842 — neuroscience — Posted on 2021-11-12
2234 An instance-specific causal framework for learning intercellular communication networks that define microenvironments of individual tumors
Chen, X.; Chen, L.; Kurten, C. H. L.; Jabbari, F.; Vujanovic, L.; Ding, Y.; Kulkarni, A.; Tabib, T.; Lafyatis, R.; Cooper, G. F.; Ferris, R.; Lu, X.
10.1101/2021.11.11.467838 — cancer biology — Posted on 2021-11-12
2235 G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis
Aurora, A. B.; Khivansara, V.; Leach, A.; Gill, J. G.; Martin-Sandoval, M.; Yang, C.; Kastininon, S. Y.; Bezwada, D.; Tasdogan, A.; Gu, W.; Mathews, T. P.; Zhao, Z.; DeBerardinis, R. J.; Morrison, S. J.
10.1101/2021.11.11.468286 — cancer biology — Posted on 2021-11-12
2237 Abnormal (hydroxy)prolines deuterium content redefines hydrogen chemical mass
Gharibi, H.; Chernobrovkin, A. L.; Eriksson, G.; Dibavar, A. S.; Timmons, Z.; Kitchener, A. C.; Kalthoff, D.; Liden, K.; Makarov, A. A.; Zubarev, R.
10.1101/2021.11.11.468216 — biochemistry — Posted on 2021-11-12
2239 Multi-regional characterisation of renal cell carcinoma and microenvironment at single cell resolution
Li, R.; Ferdinand, J. R.; Loudon, K. W.; Bowyer, G. S.; Mamanova, L.; Neves, J. B.; Bolt, L.; Fasouli, E. S.; Lawson, A. R. J.; Young, M. D.; Hooks, Y.; Oliver, T. R. W.; Butler, T. M.; Armitage, J. N.; Aho, T.; Riddick, A. C. P.; Gnanapragasam, V.; Welsh, S. J.; Meyer, K. B.; Warren, A. Y.; Tran, M. G. B.; Stewart, G. D.; Behjati, S.; Clatworthy, M. R.; Campbell, P. J.; Teichmann, S. A.; Mitchell, T. J.
10.1101/2021.11.12.468373 — genomics — Posted on 2021-11-12
2240 Thermal stress triggers productive viral infection of a key coral reef symbiont
Grupstra, C.; Howe-Kerr, L. I.; Veglia, A. J.; Bryant, R. L.; Coy, S. R.; Blackwelder, P. L.; Correa, A. M.
10.1101/2021.03.17.435810 — ecology — Posted on 2021-11-12
2241 Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division
Opalko, H. E.; Miller, K. E.; Kim, H.-S.; Vargas-Garcia, C. A.; Singh, A.; Keogh, M.-C.; Moseley, J. B.
10.1101/2021.08.17.456680 — cell biology — Posted on 2021-11-12
2245 Vitamin D deficiency increases prostatic megalin expression and globulin-bound testosterone import, increasing prostatic androgens in African American men
Garcia, J.; Krieger, K.; Loitz, C.; Perez, L. M.; Richards, Z. A.; Helou, Y. B.; Kregel, S.; Mesaros, C. A.; Gann, P.; Vander Griend, D.; Kittles, R.; Prins, G.; Penning, T.; Nonn, L.
10.1101/2021.11.09.467567 — cancer biology — Posted on 2021-11-12
2246 Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease
Kummerlowe, C.; Wallach, T.; Mwakamui, S.; Hughes, T. K.; Mulugeta, N.; Mudenda, V.; Besa, E.; Zyambo, K.; Fleming, I.; Vukovic, M.; Doran, B.; Aicher, T. P.; Wadsworth, M. H.; Bramante, J. T.; Uchida, A.; Fardoos, R.; Kloverpris, H. N.; Asowata, O. E.; Herbert, N.; Garber, J.; Ordovas-Montanes, J.; Gartner, Z.; Shalek, A. K.; Kelly, P.
10.1101/2021.04.11.439202 — genomics — Posted on 2021-11-12
2249 An ALE meta-analytic review of musical expertise
Criscuolo, A.; Pando-Naude, V.; Bonetti, L.; Vuust, P.; Brattico, E.
10.1101/2021.03.12.434473 — neuroscience — Posted on 2021-11-12
2251 The chromatin regulator HMGA1a undergoes phase separation in the nucleus
Zhu, H.; Narita, M.; Joseph, J. A.; Krainer, G.; Arter, W. E.; Saar, K. L.; Ermann, N.; Espinosa, J. R.; Shen, Y.; Kuri, M. A.; Qi, R.; Xu, Y.; Collepardo-Guevara, R.; Narita, M.; Knowles, T.
10.1101/2021.10.14.464384 — biophysics — Posted on 2021-11-12
2257 GutMicroNet: an interactive platform for gut microbiome interaction exploration
Arif, M.; Portlock, T.; Güngör, C.; Koc, E.; Özcan, B.; Subas, O.; Cakmak, B.; Turkez, H.; Uhlen, M.; Mardinoglu, A.; Shoaie, S.
10.1101/2021.11.10.468051 — systems biology — Posted on 2021-11-12
2259 A genomic assessment of the marine-speciation paradox within the toothed whale superfamily Delphinoidea
Westbury, M. V.; Cabrera, A. A.; Rey-Iglesia, A.; De Cahsan, B.; Duchene, D. A.; Hartmann, S.; Lorenzen, E. D.
10.1101/2020.10.23.352286 — evolutionary biology — Posted on 2021-11-12
2262 Sigma Oscillations Protect or Reinstate Motor Memory Depending on their Temporal Coordination with Slow Waves
Nicolas, J.; King, B. R.; Levesque, D.; Lazzouni, L.; Coffey, E. B.; Swinnen, S.; Doyon, J.; Carrier, J.; Albouy, G.
10.1101/2021.09.02.458683 — neuroscience — Posted on 2021-11-12
2263 Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation
Agetsuma, M.; Sato, I.; Tanaka, Y. R.; Carrillo-Reid, L.; Kasai, A.; Arai, Y.; Yoshitomo, M.; Inagaki, T.; Hashimoto, H.; Nabekura, J.; Nagai, T.
10.1101/2021.08.31.458461 — neuroscience — Posted on 2021-11-12
2264 Computational design of nanoscale rotational mechanics in de novo protein assemblies
Courbet, A.; Hansen, J. P.; Hsia, Y.; Bethel, N.; Park, Y.-J.; Xu, C.; Moyer, A.; Boyken, S. E.; Ueda, G.; Nattermann, U.; Nagarajan, D.; Silva, D.; Sheffler, W.; Quispe, J.; King, N. P.; Bradley, P. H.; Veesler, D.; Kollman, J. M.; Baker, D.
10.1101/2021.11.11.468255 — synthetic biology — Posted on 2021-11-12
2270 Self-organization of kinetochore-fibers in human mitotic spindles
Conway, W.; Kiewisz, R.; Fabig, G.; Kelleher, C. P.; Wu, H.-Y.; Anjur-Dietrich, M.; Mueller-Reichert, T.; Needleman, D.
10.1101/2021.11.11.468239 — biophysics — Posted on 2021-11-12
2271 Functionalizing silica sol-gel with entrapped plant virus-based immunosorbent nanoparticles
McNulty, M. J.; Hamada, N.; Delzio, J.; McKee, L.; Nandi, S.; Longo, M. L.; McDonald, K. A.
10.1101/2021.11.12.468100 — bioengineering — Posted on 2021-11-12
2272 Multiscale profiling of enzyme activity in cancer
Soleimany, A. P.; Kirkpatrick, J. D.; Wang, C. S.; Jaeger, A. M.; Su, S.; Naranjo, S.; Zhong, Q.; Cabana, C. M.; Jacks, T.; Bhatia, S.
10.1101/2021.11.11.468288 — bioengineering — Posted on 2021-11-12
2273 A DNA barcode database for the woody plants of Japan
SETSUKO, S.; YOSHIMURA, K.; UENO, S.; WORTH, J. R. P.; UJINO-IHARA, T.; KATSUKI, T.; NOSHIRO, S.; FUJII, T.; ARAI, T.; YOSHIMARU, H.
10.1101/2021.11.11.468310 — genetics — Posted on 2021-11-12
2274 Preclinical studies for plant-based oral enzyme replacement therapy (Oral-ERT) in Pompe disease knockout mice with transgenic tobacco seeds expressing human GAA (tobrhGAA)
Martiniuk, F.; Martiniuk, J.; Mack, A.; Voronin, G.; Miller, S.; Reimer, D.; Rossi, N.; Bird, L.; Gupta, R.; Nigro, M.; Saleh, S.; Meinke, P.; Schoser, B.; Wu, F.; Tchou-Wong, K. M.; Kambitsis, A.; Arvanitopoulos, J.; Arvanitopoulos, E.
10.1101/2021.11.11.468227 — genetics — Posted on 2021-11-12
2278 The dimensionality of plant-plant competition
Stouffer, D. B.; Godoy, O.; Dalla Riva, G. V. B.; Mayfield, M.
10.1101/2021.11.10.467010 — ecology — Posted on 2021-11-12
2279 BeeDNA: microfluidic environmental DNA metabarcoding as a tool for connecting plant and pollinator communities
Harper, L. R.; Niemiller, M. L.; Benito, J.; Paddock, L. E.; Knittle, E.; Molano-Flores, B.; Davis, M. A.
10.1101/2021.11.11.468290 — ecology — Posted on 2021-11-12
2280 Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation
Zhang, B.; Lee, D. E.; Trapp, A.; Tyshkovskiy, A.; Lu, A. T.; Bareja, A.; Kerepesi, C.; McKay, L. H.; Shindyapina, A. V.; Dmitriev, S. E.; Baht, G. S.; Horvath, S.; Gladyshev, V. N.; White, J. P.
10.1101/2021.11.11.468258 — cell biology — Posted on 2021-11-12
2281 Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice
Wang, Y.; Shiladardi, K.; Hsu, T.; Odinammadu, K. O.; Maruyama, T.; Wu, W.; Lin, C.-S.; Damoci, C. B.; Spear, E. D.; Shin, J.-Y.; Hsu, W.; Michaelis, S.; Worman, H. J.
10.1101/2021.11.11.465186 — cell biology — Posted on 2021-11-12
2282 G6b-B regulates an essential step in megakaryocyte maturation
Becker, I. C.; Nagy, Z.; Manukjan, G.; Haffner-Luntzer, M.; Englert, M.; Heib, T.; Voegtle, T.; Gross, C.; Bharti, R.; Dietrich, S.; Mott, K.; Heck, J.; Jeschke, A.; Schinke, T.; Schlegel, N.; Heckel, T.; Stegner, D.; Pleines, I.; Ignatius, A.; Schulze, H.; Nieswandt, B.
10.1101/2021.11.11.468226 — cell biology — Posted on 2021-11-12
2284 Optogenetic manipulation of cGMP highlights PDE5 as the predominant cGMP-hydrolyzing PDE in megakaryocytes
Zhang, Y.; Benz, P.; Stehle, D.; Yang, S.; Kurz, H.; Feil, S.; Nagel, G.; Feil, R.; Gao, S.; Bender, M.
10.1101/2021.11.12.468375 — cell biology — Posted on 2021-11-12
2286 Frizzled-4 regulates β-catenin in endothelial cells exposed to disturbed flow via an atypical Wnt pathway leading to proinflammatory activation and increased permeability
Rickman, M.; Ghim, M.; Tian Pang, K.; von Huelsen Rocha, A. C.; Drudi, E. M.; Sureda-Vives, M.; Ayoub, N.; Tajadura-Ortega, V.; George, S. J.; Weinberg, P. D.; Warboys, C. M.
10.1101/2021.11.12.468370 — cell biology — Posted on 2021-11-12
2288 The hexokinase ''HKDC1'' interaction with the mitochondria is essential for hepatocellular carcinoma progression
Khan, M. W.; Terry, A.; Priyadarshini, M.; Guzman, G.; Cordoba-Chacon, J.; Ben-Sahra, I.; Wicksteed, B.; Layden, B. T.
10.1101/2021.11.10.468146 — cancer biology — Posted on 2021-11-12
2290 RPRM negatively regulates ATM levels involving its phosphorylation mediated by CDK4/CDK6
Zhang, Y.; Ou, G.; Ye, Z.; Zhou, Z.; Cao, Q.; Li, M.; Wang, J.; Cao, J.; Yang, H.
10.1101/2021.11.10.468148 — cancer biology — Posted on 2021-11-12
2293 The C. albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells.
Russell, C. M.; Schaefer, K.; Dixson, A.; Gray, A.; Pyron, R. J.; Alves, D.; Moore, N.; Conley, E.; White, T.; Do, T.; King, G.; Barrera, F. N.
10.1101/2021.11.11.468266 — biophysics — Posted on 2021-11-12
2294 Particle localization using local gradients and its application to nanometer stabilization of a microscope
Kashchuk, A. V.; Perederiy, O.; Caldini, C.; Gardini, L.; Pavone, F. S.; Negriyko, A. M.; Capitanio, M.
10.1101/2021.11.11.468294 — biophysics — Posted on 2021-11-12
2295 Steroid-resistant nephrotic syndrome associated MYO1E mutations have differential effects on myosin 1e localization, dynamics, and activity
Liu, P.-J.; Gunther, L. K.; Perez, D.; Bi-Karchin, J.; Pellenz, C. D.; Chase, S. E.; Presti, M. F.; Plante, E. L.; Martin, C. E.; Lovric, S.; Yengo, C. M.; Hildebrandt, F.; Krendel, M.
10.1101/2021.11.11.468158 — cell biology — Posted on 2021-11-12
2296 Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks
Klug, S.; Godbersen, G. M.; Rischka, L.; Wadsak, W.; Pichler, V.; Kloebl, M.; Hacker, M.; Lanzenberger, R.; Hahn, A.
10.1101/2021.11.12.468351 — neuroscience — Posted on 2021-11-12
2299 Nitrate fertilization may delay autumn leaf senescence, while amino acid treatments do not
Fataftah, N.; Edlund, E.; Lihavainen, J.; Bag, P.; Björken, L.; Näsholm, T.; Jansson, S.
10.1101/2021.11.09.467959 — plant biology — Posted on 2021-11-12
2301 Lactate production can function to increase human epithelial cell iron concentration
Ghio, C.; Soukup, J. M.; Dailey, L. A.; Ghio, A.; Schreinemachers, D. M.; Koppes, R. A.; Koppes, A. N.
10.1101/2021.11.11.468295 — bioengineering — Posted on 2021-11-12
2302 Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
Neumann, C. M. T.; Rosenbaek, L. L.; Flygaard, R. K.; Habeck, M.; Karlsen, J. L.; Wang, Y.; Lindorff-Larsen, K.; Gad, H. H.; Hartmann, R.; Lyons, J.; Fenton, R. A.; Nissen, P.
10.1101/2021.11.11.468215 — biochemistry — Posted on 2021-11-12
2303 Ecological Differentiation Among Globally Distributed Lineages of the Rice Blast Fungus Pyricularia oryzae
Thierry, M.; Charriat, F.; Milazzo, J.; Adreit, H.; Ravel, S.; Borron, S.; Sella, V.; Kroj, T.; Ioos, R.; Fournier, E.; Tharreau, D.; Gladieux, P.
10.1101/2020.06.02.129296 — evolutionary biology — Posted on 2021-11-12
2308 ORP5 AND ORP8 ORCHESTRATE LIPID DROPLET BIOGENESIS AND MAINTENANCE AT ER-MITOCHONDRIA CONTACT SITES
Guyard, V.; Monteiro-Cardoso, V. F.; Omrane, M.; Sauvanet, C.; Houcine, A.; Boulogne, C.; MBarek, K. B.; Vitale, N.; Facklaris, O.; El Khallouki, N.; Thiam, A. R.; Giordano, F.
10.1101/2021.11.11.468233 — cell biology — Posted on 2021-11-12
2310 H3K4me3 enrichment defines neuronal age, while a youthful H3K27ac signature is recapitulated in aged neurons
Giles, K. A.; Phipps, A. J.; Cashion, J. M.; Huskins, S. N.; Mercer, T. R.; Robinson, M. D.; Woodhouse, A.; Taberlay, P. C.
10.1101/2021.11.11.467877 — molecular biology — Posted on 2021-11-12
2311 Competition and coevolution drive the evolution and the diversification of CRISPR immunity
Guillemet, M.; Chabas, H.; Nicot, A.; Gatchitch, F.; Ortega-Abboud, E.; Buus, C.; Hindhede, L.; Rousseau, G. M.; Bataillon, T.; Moineau, S.; Gandon, S.
10.1101/2021.11.12.468349 — microbiology — Posted on 2021-11-12
2312 Linking extreme seasonality and gene expression in arctic marine protists
Wutkowska, M.; Vader, A.; Logares, R.; Pelletier, E.; Gabrielsen, T. M.
10.1101/2021.11.11.467955 — microbiology — Posted on 2021-11-12
2313 Mycobacterium tuberculosis senses host Interferon- gamma via the membrane protein MmpL10
Ahmed, M.; Mackenzie, J. S.; Krause, R.; Truebody, B.; Tezera, L. B.; Garay-Baquero, D.; Vallejo, A. F.; Govender, K.; Adamson, J.; Elkington, P.; Steyn, A. J. C.; Leslie, A.
10.1101/2021.11.12.468344 — microbiology — Posted on 2021-11-12
2314 Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection
Parsa, R.; London, M.; Rezende de Castro, T. B.; Reis, B.; Buissant des Amorie, J.; Smith, J. G.; Mucida, D.
10.1101/2021.11.10.468106 — immunology — Posted on 2021-11-12
2317 Leukocyte proliferation mediates disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome
Stokes, J.; Bornstein, R.; James, K.; Park, K. Y.; Spencer, K.; Vo, K.; Snell, J.; Johnson, B. M.; Morgan, P. G.; Sedensky, M. M.; Morgan, P. G.; Baertsch, N. A.; Johnson, S. C.
10.1101/2021.11.11.468271 — pathology — Posted on 2021-11-12
2318 PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
Wiede, F.; Lu, K.-H.; Du, X.; Zessig, M.; Xu, R.; Goh, P. K.; Xirouchaki, C.; Hogarth, S.; Greatorex, S.; Sek, K.; Daly, R.; Beavis, P.; Darcy, P.; Tonks, N.; Tiganis, T.
10.1101/2021.11.11.468140 — cancer biology — Posted on 2021-11-12
2320 A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging
Chen, H.; Agrawal, S.; Osman, M.; Minotto, J.; Mirg, S.; Liu, J.; Dangi, A.; Tran, Q.; Jackson, T.; Kothapalli, S.-R.
10.1101/2021.11.09.467971 — bioengineering — Posted on 2021-11-12
2322 MICS1 is the Ca2+ /H+ antiporter of mammalian mitochondria
Austin, S.; Mekis, R.; Mohammed, S. E. M.; Scalise, M.; Pfeiffer, C.; Galluccio, M.; Borovec, T.; Parapatics, K.; Vitko, D.; Dinhopl, N.; Bennett, K. L.; Nowikovsky, K.
10.1101/2021.11.11.468204 — biochemistry — Posted on 2021-11-12
2323 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA
Laughlin, Z. T.; Dey, D.; Zelinskaya, N.; Witek, M. A.; Srinivas, P.; Nguyen, H. A.; Kuiper, E. G.; Comstock, L. R.; Dunham, C. M.; Conn, G. L.
10.1101/2021.11.11.467980 — biochemistry — Posted on 2021-11-12
2324 Acoustic and postural displays in a miniature and transparent teleost fish, Danionella dracula
Tatarsky, R. L.; Guo, Z.; Campbell, S. C.; Kim, H.; Fang, W.; Perelmuter, J. T.; Schuppe, E. R.; Reeve, H. K.; Bass, A. H.
10.1101/2021.11.10.468077 — animal behavior and cognition — Posted on 2021-11-12
2325 How ancient forest fragmentation and riparian connectivity generate high levels of genetic diversity in a micro-endemic Malagasy tree
Salmona, J.; Dresen, A.; Ranaivoson, A. E.; Manzi, S.; Le Pors, B.; Hong-Wa, C.; Razanatsoa, J.; Andriaholinirina, N. V.; Rasoloharijaona, S.; Vavitsara, M.-E.; Besnard, G.
10.1101/2020.11.25.394544 — genomics — Posted on 2021-11-12
2329 Nucleolar-based Dux repression is essential for 2-cell stage exit
Xie, S. Q.; Leeke, B. J.; Whilding, C.; Wagner, R. T.; Garcia-Llagostera, F.; Chammas, P.; Cheung, N. T.-F.; Dormann, D.; McManus, M.; Percharde, M.
10.1101/2021.11.11.468235 — developmental biology — Posted on 2021-11-12
2330 Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β
Kors, S.; Hacker, C.; Bolton, C.; Maier, R.; Reimann, L.; Kitchener, E. J. A.; Warscheid, B.; Costello, J. L.; Schrader, M.
10.1101/2021.11.11.467785 — cell biology — Posted on 2021-11-12
2339 Intestinal Transgene Delivery with Native E. coli Chassis Allows Persistent Physiological Changes
Russell, B. J.; Brown, S. D.; Saran, A. R.; Mai, I.; Lingaraju, A.; Siguenza, N.; Maissy, E.; Dantas Machado, A. C.; Pinto, A. F. M.; Miyamoto, Y.; Richter, R. A.; Ho, S. B.; Eckmann, L.; Hasty, J.; Saghatelian, A.; Knight, R.; Zarrinpar, A.
10.1101/2021.11.11.468006 — synthetic biology — Posted on 2021-11-12
2341 Genetic and epigenetic characteristics associated with. the rapid radiation of Aquilegia species
Wang, Z.-H.; Lu, T.; Li, M.-R.; Ding, N.; Lan, L.-Z.; Gao, X.; Xiong, A.-S.; Zhang, J.; Li, L.-F.
10.1101/782821 — plant biology — Posted on 2021-11-12
2342 Ensemble cryo-electron microscopy reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex
Chen, J.; Wang, Q.; Malone, B.; Llewellyn, E.; Pechersky, Y.; Maruthi, K.; Eng, E. T.; Perry, J. K.; Campbell, E. A.; Shaw, D. E.; Darst, S. A.
10.1101/2021.11.10.468168 — biophysics — Posted on 2021-11-12
2344 Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32
Mi, C.; Zhang, L.; Sun, S.; Huang, G.; Shao, G.; Yang, F.; You, X.; Dong, M.-Q.; Sui, S.-F.
10.1101/2021.11.11.468031 — biophysics — Posted on 2021-11-12
2348 Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2
Sparn, C.; Dimou, E.; Meyer, A.; Saleppico, R.; Wegehingel, S.; Gerstner, M.; Klaus, S.; Ewers, H.; Nickel, W.
10.1101/2021.11.11.468179 — biochemistry — Posted on 2021-11-12
2349 Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam
Vadlamani, G.; Sukhoverkov, K. V.; Haywood, J.; Breese, K. J.; Fisher, M. F.; Stubbs, K. A.; Bond, C. S.; Mylne, J. S.
10.1101/2021.11.10.468163 — biochemistry — Posted on 2021-11-12
2350 Deep learning methods for designing proteins scaffolding functional sites
Wang, J.; Lisanza, S.; Juergens, D.; Tischer, D.; Anishchenko, I.; Baek, M.; Watson, J. L.; Chun, J.-H.; Milles, L. F.; Dauparas, J.; Exposit, M.; Yang, W.; Saragovi, A.; Ovchinnikov, S.; Baker, D.
10.1101/2021.11.10.468128 — biochemistry — Posted on 2021-11-12
2353 Expression and novel alternative purification of the recombinant nucleocapsid (N) protein of SARS-CoV-2 in Escherichia coli for the serodiagnosis of COVID-19
Rosales, J. D.; Quintero, W.; Cruz, J.; Perdomo, B.; Quintero, M.; Bastidas, M.; Lugo, J. D.; Rodriguez, K. R.; Freites-Perez, J. C.; Castillo, A.
10.1101/2021.11.10.467990 — cell biology — Posted on 2021-11-12
2354 Spontaneous DNA synapsis by forming noncanonical intermolecular structures
Severov, V. V. V.; Tsvetkov, V. V. B.; Barinov, N. N. A.; Babenko, V. V. V.; Klinov, D. D. V.; Pozmogova, G. G. E.
10.1101/2021.11.11.468201 — molecular biology — Posted on 2021-11-12
2355 Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern
Marzi, A.; Griffin, A.; O'Donnell, K. L.; Shifflett, K.; Lavik, J.-P.; Russell, P. M.; Zimmerman, M. K.; Relich, R. F.
10.1101/2021.11.10.468174 — microbiology — Posted on 2021-11-12
2356 Alpha-hemolysin of Staphylococcus aureus impairs thrombus formation
Jahn, K.; Handtke, S.; Palankar, R.; Kohler, T. P.; Wesche, J.; Wolff, M.; Bayer, J.; Wolz, C.; Greinacher, A.; Hammerschmidt, S.
10.1101/2021.11.11.468205 — microbiology — Posted on 2021-11-12
2357 Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens
He, W.-T.; Hou, X.; Zhao, J.; Sun, J.; He, H.; Si, W.; Wang, J.; Jiang, Z.; Yan, Z.; Xing, G.; Lu, M.; Suchard, M. A.; Ji, X.; Gong, W.; He, B.; Li, J.; Lemey, P.; Guo, D.; Tu, C.; Holmes, E. C.; Shi, M.; Su, S.
10.1101/2021.11.10.467646 — zoology — Posted on 2021-11-12
2358 MicNet Toolbox: visualizing and deconstructing a microbial network
Favila, N.; Madrigal-Trejo, D.; Legorreta, D.; Sanchez-Perez, J.; Espinosa-Asuar, L.; Saldivar, V.
10.1101/2021.11.11.468289 — bioinformatics — Posted on 2021-11-11
2362 Cortico-Subcortical Interactions in Overlapping Communities of Edge Functional Connectivity
Chumin, E. J.; Faskowitz, J.; Zamani Esfahlani, F.; Jo, Y.; Merritt, H. L.; Tanner, J. C.; Cutts, S. A.; Pope, M. E.; Sporns, O.; Betzel, R.
10.1101/2021.10.19.465016 — neuroscience — Posted on 2021-11-11
2365 NeuroMechFly, a neuromechanical model of adult Drosophila melanogaster
Lobato Rios, V.; Ramalingasetty, S. T.; Ozdil, G. P.; Arreguit, J.; Ijspeert, A.; Ramdya, P.
10.1101/2021.04.17.440214 — neuroscience — Posted on 2021-11-11
2366 GutMicroNet: an interactive platform for gut microbiome interaction exploration
Arif, M.; Portlock, T.; Güngör, C.; Koc, E.; Özcan, B.; Subas, O.; Cakmak, B.; Uhlen, M.; Mardinoglu, A.; Shoaie, S.
10.1101/2021.11.10.468051 — systems biology — Posted on 2021-11-11
2368 Mutant-SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms
Carratt, S. A.; Kong, G. L.; Smith, B. M.; Schonrock, Z.; Maloney, L.; Baris, A.; Druker, B. J.; Braun, T. P.; Maxson, J. E.
10.1101/2021.11.04.467367 — cancer biology — Posted on 2021-11-11
2369 Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination
Meyer, K. J.; Larson, D. R.; Whitmore, S. S.; van der Heide, C. J.; Hedberg-Buenz, A.; Dutca, L. M.; Koli, S.; Pomernackas, N.; Mercer, H. E.; Mansaray, M. N.; Paradee, W. J.; Wang, K.; Nair, K. S.; Scheetz, T. E.; Anderson, M. G.
10.1101/2021.09.22.461410 — genetics — Posted on 2021-11-11
2372 The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
Stormo, A. E. D.; Shavarebi, F.; FitzGibbon, M.; Earley, E. M.; Ahrendt, H.; Lum, L. S.; Verschueren, E.; Swaney, D. L.; Skibinski, G.; Ravisankar, A.; van Haren, J.; Davis, E. J.; Johnson, J. R.; Von Dollen, J.; Mirescu, C.; Balen, C.; Porath, J.; Crosio, C.; Iaccarino, C.; Dauer, W. T.; Nichols, R. J.; Wittmann, T.; Cox, T. C.; Finkbeiner, S.; Krogan, N. J.; Oakes, S. A.; Hiniker, A.
10.1101/2020.10.21.336578 — molecular biology — Posted on 2021-11-11
2373 A Scalable Screening of E. coli Strains for Recombinant Protein Expression
Morao, L. G.; Manzine, L. R.; Barra, A. L. C.; Clementino, L. O. D.; Gutierrez, R. F.; Wrenger, C.; Nascimento, A. S.
10.1101/2021.03.09.434560 — molecular biology — Posted on 2021-11-11
2375 Interneuron Control of C. elegans Developmental Decision-making
Chai, C. M.; Torkashvand, M.; Seyedolmohadesin, M.; Park, H.; Venkatachalam, V.; Sternberg, P. W.
10.1101/2021.11.07.467589 — neuroscience — Posted on 2021-11-11
2376 Effective Cell Membrane Tension is Independent of Substrate Stiffness
Kreysing, E.; Mc Hugh, J.; Foster, S. K.; Andresen, K.; Greenhalgh, R. D.; Pillai, E. K.; Dimitracopoulos, A.; Keyser, U. F.; Franze, K.
10.1101/2021.11.09.467973 — biophysics — Posted on 2021-11-11
2378 ImputeCoVNet: 2D ResNet Autoencoder for Imputation of SARS-CoV-2 Sequences
Pesaranghader, A.; Pelletier, J.; Grenier, J.-C.; Poujol, R.; Hussin, J.
10.1101/2021.08.13.456305 — bioinformatics — Posted on 2021-11-11
2380 Toeholder: a software for automated design and in silico validation of toehold riboswitches
Cisneros Caballero, A. F.; Rouleau, F. D.; Bautista, C.; Lemieux, P.; Dumont-Leblond, N.
10.1101/2021.11.09.467922 — bioinformatics — Posted on 2021-11-11
2381 Acoustic and postural displays in a miniature and transparent teleost fish, Danionella dracula
Tatarsky, R. L.; Guo, Z.; Campbell, S. C.; Kim, H.; Fang, W.; Perelmuter, J. T.; Schuppe, E. R.; Reeve, H. K.; Bass, A. H.
10.1101/2021.11.10.468077 — animal behavior and cognition — Posted on 2021-11-11
2386 Integration of vascular progenitors into functional blood vessels represents a novel mechanism of vascular growth
Metikala, S.; Warkala, M.; Casie Chetty, S.; Chestnut, B.; Plender, E.; Nester, O.; Astrof, S.; Sumanas, S.
10.1101/2021.11.09.467331 — developmental biology — Posted on 2021-11-11
2388 Human Sex Matters: Y-linked lysine demethylase 5D drives accelerated male osteogenic differentiation
Merten, M.; Greiner, J. F. W.; Niemann, T.; Venhaus, M. G.; Kronenberg, D.; Stange, R.; Waehnert, D.; Kaltschmidt, C.; Vordemvenne, T.; Kaltschmidt, B.
10.1101/2021.11.10.468047 — cell biology — Posted on 2021-11-11
2390 Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development
Jewett, C. E.; McCurdy, B. L.; O'Toole, E. T.; Given, K. S.; Lin, C. H.; Olsen, V.; Martin, W.; Reinholdt, L. G.; Espinosa, J. M.; Sullivan, K. D.; Macklin, W. B.; Prekeris, R.; Pearson, C. G.
10.1101/2021.11.10.468107 — cell biology — Posted on 2021-11-11
2391 Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice
Belouzard, S.; Machelart, A.; Sencio, V.; Vausselin, T.; Hoffmann, E.; Deboosere, N.; Rouille, Y.; Desmarets, L.; Seron, K.; Danneels, A.; Robil, C.; Belloy, L.; Moreau, C.; Piveteau, C.; Biela, A.; Vandeputte, A.; Heumel, S.; Deruyter, L.; Dumont, J.; Leroux, F.; Engelmann, I.; Alidjinou, E. K.; Hober, D.; Brodin, P.; Beghyn, T.; Trottein, F.; Deprez, B.; Dubuisson, J.
10.1101/2021.06.30.450483 — microbiology — Posted on 2021-11-11
2393 Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
Claiborne, M.; Sengupta, S.; Zhao, L.; Arwood, M. L.; Sun, I.-M.; Wen, J.; Thompson, E. A.; Mitchell-Flack, M.; Laiho, M.; Powell, J. D.
10.1101/2021.11.10.468070 — immunology — Posted on 2021-11-11
2398 An essential role for a discrete parasubthalamic nucleus subpopulation in appetite suppression
Kim, J. H.; Kromm, G. H.; Barnhill, O. K.; Han, K.; Heuer, L. B.; Loomis, S.; Newman, M. C.; Sperber, J.; Legan, T. B.; Gulamali, F. F.; Jensen, K. E.; Funderburk, S. C.; Krashes, M. J.; Carter, M. E.
10.1101/2021.11.10.468058 — neuroscience — Posted on 2021-11-11
2401 Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing
Newton, S.; Kong, F.; Carlton, A. J.; Aguilar, C.; Parker, A.; Codner, G. F.; Teboul, L.; Wells, S.; Brown, S. D.; Marcotti, W.; Bowl, M.
10.1101/2021.11.10.468016 — neuroscience — Posted on 2021-11-11
2406 Attractor Landscapes as a Model Selection Criterion in Data Poor Environments
Lyman, C. A.; Richman, S.; Morris, M. C.; Cao, H.; Scerri, A.; Cheadle, C.; Broderick, G.
10.1101/2021.11.09.466986 — systems biology — Posted on 2021-11-11
2407 Cell Wall Biochemistry Drives Pollen Tube Mechanics and Affects Growth Rate
Vogler, H.; Munglani, G.; Ndinyanka Fabrice, T.; Draeger, C.; Burri, J. T.; Eichenberger, C.; Knox, J. P.; Mollet, J.-C.; Nelson, B. J.; Herrmann, H. J.; Ringli, C.; Grossniklaus, U.
10.1101/2021.11.09.467870 — systems biology — Posted on 2021-11-11
2413 A graph neural network approach to molecule carcinogenicity prediction
Fradkin, P.; Young, A.; Atanackovic, L.; Frey, B. J.; Lee, L. J.; Wang, B.
10.1101/2021.11.10.468094 — bioinformatics — Posted on 2021-11-11
2416 ODGI: understanding pangenome graphs
Guarracino, A.; Heumos, S.; Nahnsen, S.; Prins, P.; Garrison, E.
10.1101/2021.11.10.467921 — genomics — Posted on 2021-11-11
2417 Chromosome scale assembly of allopolyploid genome of the diatom Fistulifera solaris
Maeda, Y.; Watanabe, K.; Kobayashi, R.; Yoshino, T.; Bowler, C.; Matsumoto, M.; Tanaka, T.
10.1101/2021.11.10.468027 — genomics — Posted on 2021-11-11
2419 Transgenerational impact of aberrant inflammation in rat pregnancy
Ushida, T.; Cotechini, T.; Protopapas, N.; Atallah, A.; Collyer, C.; Macdonald-Goodfellow, S. K.; Tse, M. Y.; Winn, L. M.; Pang, S. C.; Adams, M. A.; Othman, M.; Kotani, T.; Kajiyama, H.; Graham, C. H.
10.1101/2021.11.09.467505 — developmental biology — Posted on 2021-11-11
2420 Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts
Buganim, Y.; Naama, M.; Radwan, A.; Zayat, V.; Sebban, S.; Rahamim, M.; Lasry, R.; Jaber, M.; Sabag, O.; Yassen, H.; Orzech, D.; Khatib, A.; Epsztejn-Litman, S.; Novoselsky-Persky, M.; Makedonski, K.; Deri, N.; Goldman-Wohl, D.; Cedar, H.; Yagel, S.; Eiges, R.
10.1101/2021.11.10.468044 — cell biology — Posted on 2021-11-11
2421 Club cells are the primary source of pIgR in small airways
Blackburn, J. B.; Schaff, J. A.; Gutor, S.; Du, R.-H.; Nichols, D.; Sherrill, T.; Gutierrez, A. J.; Xin, M. K.; Wickersham, N.; Zhang, Y.; Holtzman, M. J.; Ware, L. B.; Lee, J. W.; Banovich, N. E.; Kropski, J. A.; Polosukhin, V. V.; Blackwell, T. S.; Richmond, B. W.
10.1101/2021.11.10.467794 — cell biology — Posted on 2021-11-11
2425 Determining the architecture of nuclear ring of Xenopus laevis nuclear pore complex using integrated approaches
Ren, H.; Tai, L.; Zhu, Y.; Chan, C.; Zhao, Q.; Xu, J.; Wang, X.; Ma, X.; Zhao, L.; Huang, X.; Yin, G.; Jia, M.; Zhu, X.; An, Y.; Zhao, G.; Huang, C.; Zhang, L.; Fan, J.; Sun, F.; Zhang, C.
10.1101/2021.11.10.468004 — molecular biology — Posted on 2021-11-11
2427 Increased frequency of CD4+ and CD8+ follicular helper T cells in human lymph node biopsies during the earliest stages of rheumatoid arthritis
Anang, D. C.; Ramwadhdoebe, T. H.; Hahnlein, J.; van Kuijk, B.; Smits, N.; van Lienden, K. P.; Maas, M.; Gerlag, D. M.; Tak, P. P.; de Vries, N.; van Baarsen, L. G.
10.1101/2021.11.10.467883 — immunology — Posted on 2021-11-11
2429 Age-dependent formation of TMEM106B amyloid filaments in human brain
Schweighauser, M.; Arseni, D.; Huang, M.; Lövestam, S.; Shi, Y.; Yang, Y.; Zhang, W.; Kotecha, A.; Garringer, H. J.; Vidal, R.; Hallinan, G. I.; Newell, K. L.; Tarutani, A.; Murayama, S.; Miyazaki, M.; Saito, Y.; Yoshida, M.; Hasegawa, K.; Lashley, T.; Revesz, T.; Kovacs, G. G.; van Swieten, J.; Takao, M.; Hasegawa, M.; Ghetti, B.; Falcon, B.; Murzin, A. G.; Goedert, M.; Scheres, S.
10.1101/2021.11.09.467923 — neuroscience — Posted on 2021-11-11
2433 Cortico-striatal activity characterizes human safety learning via Pavlovian conditioned inhibition
Laing, P. A.; Steward, T.; Davey, C.; Felmingham, K.; Fullana, M.; Vervliet, B.; Greaves, M.; Moffatt, B.; Glarin, R.; Harrison, B. J.
10.1101/2021.11.09.467993 — neuroscience — Posted on 2021-11-11
2435 Neurons derived from individual early Alzheimer's disease patients reflect clinical vulnerability
Ng, B.; Rowland, H.; Wei, T.; Arunasalam, K.; Hayes, E. M.; Koychev, I.; Hedegaard, A.; Ribe, E. M.; Chan, D.; Chessell, T.; ffytche, D.; Gunn, R. N.; Kocagoncu, E.; Lawson, J.; Malhotra, P.; Ridha, B. H.; Rowe, J. B.; Thomas, A. J.; Zamboni, G.; Buckley, N.; Cader, Z. M.; Lovestone, S.; Wade-Martins, R.
10.1101/2021.11.09.467891 — neuroscience — Posted on 2021-11-11
2437 NIfTI-MRS: A standard format for magnetic resonance spectroscopic data
Clarke, W. T.; Mikkelsen, M.; Oeltzschner, G.; Bell, T.; Shamaei, A.; Soher, B. J.; Emir, U. E.; Wilson, M.
10.1101/2021.11.09.467912 — neuroscience — Posted on 2021-11-11
2439 Lipophorin receptors regulate mushroom bodies development and participate in learning, memory, and sleep in flies
Rojo-Cortes, F.; Tapia-Valladares, V.; Fuenzalida-Uribe, N.; Hidalgo, S.; Roa, C. B.; Gonzalez-Ramirez, M.-C.; Oliva, C.; Campusano, J. M.; Marzolo, M.-P.
10.1101/2021.11.10.467940 — neuroscience — Posted on 2021-11-11
2440 Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation.
Arrazola, M. S.; Lira, M.; Quiroz, G.; Iqbal, S.; Eaton, S. L.; Kline, R. A.; Lamont, D. J.; Huerta, H.; Ureta, G.; Bernales, S.; Cardenas, J. C.; Cerpa, W.; Wishart, T. M.; Court, F. A.
10.1101/2021.11.10.468052 — neuroscience — Posted on 2021-11-11
2441 Reliability of quantitative multiparameter maps is high for MT and PD but attenuated for R1 and R2* in healthy young adults
Wenger, E.; Polk, S. E.; Kleemeyer, M. M.; Weiskopf, N.; Bodammer, N. C.; Lindenberger, U.; Brandmaier, A. M.
10.1101/2021.11.10.467254 — neuroscience — Posted on 2021-11-11
2443 Real-time motion monitoring improves functional MRI data quality in infants
D'Andrea, C. B.; Kenley, J. K.; Montez, D. F.; Mirro, A. E.; Miller, R. L.; Earl, E. A.; Koller, J. M.; Sung, S.; Yacoub, E.; Elison, J. T.; Fair, D.; Dosenbach, N. U. F.; Rogers, C.; Smyser, C. D.; Greene, D. J.
10.1101/2021.11.10.468084 — neuroscience — Posted on 2021-11-11
2448 A novel cryo-electron microscopy support film based on 2D crystal of HFBI protein
Fan, H.; Wang, B.; Zhang, Y.; Zhu, Y.; Song, B.; Xu, H.; Zhai, Y.; Qiao, M.; Sun, F.
10.1101/2021.11.09.467987 — biophysics — Posted on 2021-11-11
2452 Robust and generalizable segmentation of human functional tissue units
Godwin, L. L.; Ju, Y.; Sood, N.; Jain, Y.; Quardokus, E. M.; Bueckle, A.; Longacre, T.; Horning, A. M.; Lin, Y.; Esplin, E. D.; Hickey, J. W.; Snyder, M. P.; Patterson, N. H.; Spraggins, J. M.; Borner, K.
10.1101/2021.11.09.467810 — bioinformatics — Posted on 2021-11-11
2455 Deciphering the language of antibodies using self-supervised learning
Leem, J.; Mitchell, L. S.; Farmery, J. H. R.; Barton, J.; Galson, J. D.
10.1101/2021.11.10.468064 — bioinformatics — Posted on 2021-11-11
2459 Weakly-Supervised Tumor Purity Prediction FromFrozen H&E Stained Slides
Brendel, M.; Getseva, V.; Al Assaad, M.; Sigouros, M.; Sigaras, A.; Kane, T.; Khosravi, P.; Mosquera, J. M.; Elemento, O.; Hajirasouliha, I.
10.1101/2021.11.09.467901 — bioinformatics — Posted on 2021-11-11
2463 A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging
Chen, H.; Agrawal, S.; Osman, M.; Minotto, J.; Mirg, S.; Liu, J.; Dangi, A.; Tran, Q.; Jackson, T.; Kothapalli, S.-R.
10.1101/2021.11.09.467971 — bioengineering — Posted on 2021-11-11
2465 FLIP: Benchmark tasks in fitness landscape inference for proteins
Dallago, C.; Mou, J.; Johnston, K. E.; Wittmann, B.; Bhattacharya, N.; Goldman, S. L.; Madani, A.; Yang, K. K.
10.1101/2021.11.09.467890 — bioengineering — Posted on 2021-11-11
2466 Fast anther dehiscence state recognition system establishing by deep learning to screen heat tolerant cotton
Tan, Z.; Shi, J.; Lv, R.; Li, Q.; Yang, J.; Ma, Y.; Li, Y.; Wu, Y.; Zhang, R.; Ma, H.; Li, Y.; Zhu, L.; Kong, J.; Zhang, X.; Yang, W.; Min, L.
10.1101/2021.11.09.467902 — bioengineering — Posted on 2021-11-11
2467 SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication
Kee, J.; Thudium, S.; Renner, D.; Glastad, K.; Palozola, K.; Zhang, Z.; Li, Y.; Cesare, J.; Lan, Y.; Truitt, R.; Cardenas-Diaz, F. L.; Kotton, D. N.; Alysandratos, K. D.; Zhang, X.; Xie, X.; Shi, P.-Y.; Yang, W.; Morrisey, E.; Garcia, B. A.; Berger, S. L.; Weiss, S. R.; Korb, E.
10.1101/2021.11.10.468057 — genetics — Posted on 2021-11-11
2470 Transcriptome innovations in primates revealed by single-molecule long-read sequencing
Ferrandez-Peral, L.; Zhan, X.; Alvarez-Estape, M.; Chiva, C.; Esteller-Cucala, P.; Garcia-Perez, R.; Julia, E.; Lizano, E.; Fornas, O.; Sabido, E.; Li, Q.; Marques-Bonet, T.; Juan, D.; Zhang, G.
10.1101/2021.11.10.468034 — evolutionary biology — Posted on 2021-11-11
2473 Large cells activate global protein degradation to maintain cell size homeostasis
Liu, S.; Tan, C.; Melo-Gavin, C.; Mark, K. G.; Ginzberg, M. B.; Blutrich, R.; Patel, N.; Rape, M.; Kafri, R.
10.1101/2021.11.09.467936 — cell biology — Posted on 2021-11-11
2475 A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
Lechuga, S.; Cartagena-Rivera, A. X.; Khan, A.; Crawford, B. I.; Narayanan, V.; Conway, D. E.; Lehtimaki, J.; Lappalainen, P.; Rieder, F.; Longworth, M. S.; Ivanov, A. I.
10.1101/2021.11.10.467974 — cell biology — Posted on 2021-11-11
2477 Fascicles split or merge every ~560 microns within the human cervical vagus nerve
Upadhye, A. R.; Kolluru, C.; Druschel, L.; Al Lababidi, L.; Ahmad, S.; Menendez, D.; Buyukcelik, O. N.; Settell, M. L.; Jenkins, M. W.; Wilson, D.; Zhang, J.; Tatsuoka, C.; Grill, W. M.; Pelot, N. A.; Ludwig, K.; Gustafson, K. J.; Shoffstall, A. J.
10.1101/2021.11.09.467343 — neuroscience — Posted on 2021-11-11
2479 Compositional Restricted Boltzmann Machines Unveil the Brain-Wide Organization of Neural Assemblies
van der Plas, T. L.; Tubiana, J.; Le Goc, G.; Migault, G.; Kunst, M.; Baier, H.; Bormuth, V.; Englitz, B.; Debregeas, G.
10.1101/2021.11.09.467900 — neuroscience — Posted on 2021-11-11
2483 Learning enhances behaviorally relevant representations in apical dendrites
Benezra, S. E.; Patel, K. B.; Perez Campos, C.; Hillman, E. M. C.; Bruno, R. M.
10.1101/2021.11.10.468144 — neuroscience — Posted on 2021-11-11
2486 Quantitative isotope-labeled crosslinker proteomics reveals developmental variation in protein interactions and posttranslational modifications in Diaphorina citri, the citrus greening insect vector
Ramsey, J. S.; Zhong, X.; Saha, S.; Chavez, J. D.; Johnson, R.; Mahoney, J. E.; Keller, A.; Moulton, K.; Mueller, L. A.; Hall, D. G.; MacCoss, M. J.; Bruce, J. E.; Heck, M. L.
10.1101/2021.11.09.467860 — systems biology — Posted on 2021-11-11
2489 Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE-2 in vitro
Khanna, K.; Raymond, W.; Jin, J.; Charbit, A. R.; Gitlin, I.; Tang, M.; Werts, A. D.; Barrett, E. G.; Cox, J. M.; Birch, S. M.; Martinelli, R.; Sperber, H. S.; Franz, S.; Pillai, S.; Healy, A. M.; Duff, T.; Oscarson, S.; Hoffmann, M.; Pohlmann, S.; Simmons, G.; Fahy, J. V.
10.1101/2020.12.08.415505 — microbiology — Posted on 2021-11-11
2490 B cell clonal expansion is correlated with antigen-specificity in young but not old mice
Agrafiotis, A.; Neumeier, D.; Hong, K.-L.; Chowdhury, T.; Ehling, R. A.; Kuhn, R.; Sandu, I.; Kreiner, V.; Starkie, D.; Lightwood, D. J.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2021.11.09.467876 — immunology — Posted on 2021-11-11
2492 Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator
Abdelfattah, A. S.; Zheng, J.; Reep, D.; Tsegaye, G.; Tsang, A.; Arthur, B. J.; Rehorova, M.; Olson, C. V.; Huang, Y.-C.; Shuai, Y.; Koyama, M.; Moya, M. V.; Weber, T. D.; Lemire, A. L.; Baker, C. A.; Falco, N.; Zheng, Q.; Grimm, J. B.; Yip, M. C.; Walpita, D.; Forest, C. R.; Chase, M.; Campagnola, L.; Murphy, G.; Wong, A. M.; Mertz, J.; Economo, M. N.; Turner, G.; Lin, B.-J.; Chen, T.-W.; Novak, O.; Lavis, L. D.; Svoboda, K.; Korff, W.; Schreiter, E. R.; Hasseman, J. P.; Kolb, I.
10.1101/2021.11.09.467909 — neuroscience — Posted on 2021-11-11
2500 Seizure localisation with attention-based graph neural networks
Grattarola, D.; Livi, L.; Alippi, C.; Wennberg, R.; Valiante, T.
10.1101/2020.12.03.409979 — neuroscience — Posted on 2021-11-11
2502 2,3-cAMP treatment mimics stress molecular response in Arabidopsis thaliana
Chodasiewicz, M.; Kerber, O.; Gorka, M.; Moreno Beltran, J. C.; Maruri Lopez, I.; Minen, R.; Sampathkumar, A.; Skirycz, A.
10.1101/2021.07.12.452129 — plant biology — Posted on 2021-11-11
2503 Deamidated TPI is an efficacious target for cell-selective therapy in triple-negative breast cancer
Enriquez-Flores, S.; Flores-Lopez, L. A.; de la Mora-de la Mora, I.; Garcia-Torres, I.; Gracia-Mora, I.; Gutierrez-Castrellon, P.; Fernandez-Lainez, C.; Martinez-Perez, Y.; Olaya-Vargas, A.; Lopez-Velazquez, G.
10.1101/2021.11.09.467888 — cancer biology — Posted on 2021-11-11
2505 The beryllium fluoride form of the Na+,K+-ATPase and the intermediates of the functional cycle
Fruergaard, M. U.; Dach, I.; Andersen, J. L.; Ozol, M.; Shahsavar, A.; Quistgaard, E. M.; Poulsen, H.; Fedosova, N. U.; Nissen, P.
10.1101/2021.11.08.467847 — biochemistry — Posted on 2021-11-11
2506 Lysosome-targeted lipid probes reveal sterol transporters NPC1 and LIMP2 as sphingosine transporters
Altuzar, J.; Notbohm, J.; Stein, F.; Haberkant, P.; Heybrock, S.; Worsch, J.; Saftig, P.; Höglinger, D.
10.1101/2021.11.10.468010 — cell biology — Posted on 2021-11-11
2507 OptiFit: an improved method for fitting amplicon sequences to existing OTUs
Sovacool, K. L.; Westcott, S. L.; Mumphrey, M. B.; Dotson, G. A.; Schloss, P. D.
10.1101/2021.11.09.468000 — microbiology — Posted on 2021-11-11
2508 A single cell atlas of human and mouse white adipose tissue
Emont, M. P.; Jacobs, C.; Essene, A. L.; Pant, D.; Tenen, D.; Colleluori, G.; De Vincenzo, A.; Jorgensen, A. M.; Dashti, H.; Stefek, A.; McGonagle, E.; Strobel, S.; Laber, S.; Agrawal, S.; Westcott, G. P.; Kar, A.; Veregge, M. L.; Gulko, A.; Srinivasan, H.; Kramer, Z.; De Filippis, E.; Merkel, E.; Ducie, J.; Boyd, C. G.; Gourash, W.; Courcoulas, A.; Lin, S. J.; Lee, B. T.; Morris, D.; Tobias, A.; Khera, A. V.; Claussnitzer, M.; Pers, T. H.; Giordano, A.; Ashenberg, O.; Regev, A.; Tsai, L. T.; Rosen, E. D.
10.1101/2021.11.09.466968 — physiology — Posted on 2021-11-11
2509 Landscape, complexity and regulation of a filamentous fungal transcriptome
Lu, P.; Chen, D.; Qi, Z.; Wang, H.; Chen, Y.; Wang, Q.; Jiang, C.; Liu, H.; Xu, J.-R.
10.1101/2021.11.08.467853 — genomics — Posted on 2021-11-11
2511 2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases
Bidou, L.; Bugaud, O.; Merer, G.; Coupet, M.; Hatin, I.; Chirkin, E.; Francois, P.; Cintrat, J.-C.; Namy, O.
10.1101/2021.11.09.467859 — molecular biology — Posted on 2021-11-11
2512 Heritability of hippocampal functional and microstructural organisation
Bayrak, S.; Vos de Wael, R.; Schaare, H. L.; Caldairou, B.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B. C.; Valk, S. L.
10.1101/2021.11.10.468049 — neuroscience — Posted on 2021-11-11
2514 Maf1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass
Busschers, E.; Ahmad, N.; Sun, L.; Iben, J. R.; Walkey, C. J.; Rusin, A.; Yuen, T.; J. Rosen, C.; Willis, I. M.; Zaidi, M.; Johnson, D. L.
10.1101/2021.11.09.467887 — cell biology — Posted on 2021-11-11
2523 Equatorial to Polar genomic variability of the microalgae Bathycoccus prasinos
Leconte, J.; Timsit, Y.; Delmont, T. O.; Lescot, M.; Piganeau, G.; Wincker, P.; Jaillon, O.
10.1101/2021.07.13.452163 — genomics — Posted on 2021-11-11
2525 The genetic diversity of Ethiopian barley genotypes in relation to their geographical origin
Teklemariam, S. S.; Bayissa, K. N.; Matros, A.; Pillen, K.; Ordon, F.; Wehner, G.
10.1101/2021.11.10.468099 — genetics — Posted on 2021-11-10
2526 A platform of patient-derived microtumors identifies treatment response and therapeutic vulnerabilities of ovarian cancer
Anderle, N.; Koch, A.; Gierke, B.; Keller, A.-L.; Staebler, A.; Hartkopf, A.; Brucker, S.; Pawlak, M.; Schenke-Layland, K.; Schmees, C.
10.1101/2021.11.10.468007 — cancer biology — Posted on 2021-11-10
2527 VALIS: Virtual Alignment of pathoLogy Image Series
Gatenbee, C. D.; Baker, A.-M.; Prabhakaran, S.; Slebos, R. J. C.; Mandal, G.; Mulholland, E.; Leedham, S.; Conejo-Garcia, J. R.; Chung, C. H.; Robertson-Tessi, M.; Graham, T. A.; Anderson, A. R. A.
10.1101/2021.11.09.467917 — cancer biology — Posted on 2021-11-10
2530 Biological integrity enhances the qualitative effectiveness of conditional mice-oak mutualisms
Diaz, M.; Moran-Lopez, T.; Sanchez-Davila, J.; Torre, I.; Navarro-Castilla, A.; Barja, I.
10.1101/2021.11.10.468095 — ecology — Posted on 2021-11-10
2532 In vivo label-free observation of tumor-related blood vessels in small animals using a newly designed photoacoustic 3D imaging system
Asao, Y.; Nagae, K.-i.; Miyasaka, K.; Sekiguchi, H.; Aiso, S.; Watanabe, S.; Sato, M.; Kondoh, S. K.; Nakajima, Y.; Kishi, K.; Yagi, T.
10.1101/2021.11.09.467878 — cancer biology — Posted on 2021-11-10
2533 Recurrent activating mutations in AHR act as drivers of urinary tract cancer
Vlaar, J.; Borgman, A.; Kalkhoven, E.; Besselink, N.; Shale, C.; Faltas, B. M.; Priestley, P.; Kuijk, E.; Cuppen, E.
10.1101/2021.11.09.468005 — cancer biology — Posted on 2021-11-10
2534 Vitamin D deficiency increases prostatic megalin expression and globulin-bound testosterone import, increasing prostatic androgens in African American men
Garcia, J.; Krieger, K.; Loitz, C.; Perez, L. M.; Richards, Z. A.; Helou, Y. B.; Kregel, S.; Mesaros, C. A.; Gann, P.; Vander Griend, D.; Kittles, R.; Prins, G.; Penning, T.; Nonn, L.
10.1101/2021.11.09.467567 — cancer biology — Posted on 2021-11-10
2537 Aspergillus fumigatus drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis
Okaa, U. J.; Bertuzzi, M.; Fortune-Grant, R.; Thomson, D. D.; Moyes, D. L.; Naglik, J. R.; Bignell, E.
10.1101/2021.11.09.468003 — microbiology — Posted on 2021-11-10
2538 Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1
El Ghaleb, Y. E.; Ortner, N. J.; Posch, W.; Fernandez-Quintero, M. L.; Tuinte, W. E.; Monteleone, S.; Draheim, H. J.; Liedl, K. R.; Wilflingseder, D.; Striessnig, J.; Tuluc, P.; Flucher, B. E.; Campiglio, M.
10.1101/2021.11.10.468074 — physiology — Posted on 2021-11-10
2542 CDK1 and PLK1 cooperate to regulate BICD2, dynein activation and recruitment to the nucleus as well as centrosome separation in G2/M
Gallisa-Sune, N.; Sanchez-Fernandez-de-Landa, P.; Zimmermann, F.; Serna, M.; Paz, J.; Regue, L.; Llorca, O.; Luders, J.; Roig, J.
10.1101/2021.11.04.467245 — cell biology — Posted on 2021-11-10
2546 Bacterial quorum sensing allows graded and bimodal cellular responses to variations in population density
Rattray, J. B.; Thomas, S. A.; Wang, Y.; Molotkova, E.; Gurney, J.; Varga, J.; Brown, S. P.
10.1101/850297 — microbiology — Posted on 2021-11-10
2547 Fast and sensitive GCaMP calcium indicators for imaging neural populations
Looger, L.; Zhang, Y.; Rozsa, M.; Liang, Y.; Bushey, D.; Wei, Z.; Zheng, J.; Reep, D.; Broussard, G. J.; Tsang, A.; Tsegaye, G.; Narayan, S.; Obara, C. J.; Lim, J.-X.; Patel, R.; Zhang, R.; Ahrens, M. B.; Turner, G. C.; Wang, S. S.; Korff, W.; Schreiter, E. R.; Svoboda, K.; Hasseman, J. P.; Kolb, I.
10.1101/2021.11.08.467793 — neuroscience — Posted on 2021-11-10
2549 Delineation of insula dynorphin and kappa opioid receptor circuit elements in alcohol consumption
Pina, M.; Pati, D.; Neira, S.; Stanhope, C.; Mahoney, A.; D'Ambrosio, S.; kash, t.; Navarro, M.
10.1101/2021.11.09.467893 — neuroscience — Posted on 2021-11-10
2550 Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes
Banse, S. A.; Sedore, C. A.; Johnson, E.; Coleman-Hulbert, A. L.; Onken, B.; Hall, D.; Jackson, E. G.; Huynh, P.; Foulger, A. C.; Guo, S.; Garrett, T.; Xue, J.; Inman, D.; Morshead, M. L.; Plummer, W. T.; Chen, E.; Bhaumik, D.; Chen, M. K.; Harinath, G.; Chamoli, M.; Quinn, R. P.; Falkowski, R.; Edgar, D.; Schmidt, M. O.; Lucanic, M.; Guo, M.; Driscoll, M.; Lithgow, G. J.; Phillips, P. C.
10.1101/2021.11.09.464847 — physiology — Posted on 2021-11-10
2554 Median based absolute quantification of proteins using Fully Unlabelled Generic Internal Standard
Raghuraman, B. K.; Bogdanova, A.; Moon, H.; Rzagalinski, I.; Geertsma, E.; Hersemann, L.; Shevchenko, A.
10.1101/2021.06.28.450203 — biochemistry — Posted on 2021-11-10
2555 Population structure analysis and laboratory monitoring of Shigella with a standardised core-genome multilocus sequence typing scheme
Yassine, I.; Lefevre, S.; Hansen, E. E.; Ruckly, C.; Carle, I.; Lejay-Collin, M.; Fabre, L.; Rafei, R.; Clermont, D.; Pardos de la Gandara, M.; Dabboussi, F.; Thomson, N. R.; Weill, F.-X.
10.1101/2021.06.08.447214 — genomics — Posted on 2021-11-10
2558 Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease
Baumann, J.; Sachs, L.; Otto, O.; Schoen, I.; Nestler, P.; Zaninetti, C.; Kenny, M.; Kranz, R.; von Eysmondt, H.; Rodriguez, J.; Schaeffer, T.; Nagy, Z.; Greinacher, A.; Palankar, R.; Bender, M.
10.1101/2021.11.10.468045 — cell biology — Posted on 2021-11-10
2559 Deep assessment of human disease-associated ribosomal RNA modifications using Nanopore direct RNA sequencing
Naarmann-de Vries, I. S.; Zorbas, C.; Lemsara, A.; Bencun, M.; Schudy, S.; Meder, B.; Eschenbach, J.; Lafontaine, D. L.; Dieterich, C.
10.1101/2021.11.10.467884 — molecular biology — Posted on 2021-11-10
2563 Colonial choanoflagellate isolated from Mono Lake harbors a microbiome
Hake, K.; West, P. T.; McDonald, K. L.; Laundon, D.; Garcia De Las Bayonas, A.; Feng, C.; Burkhardt, P.; Richter, D. J.; Banfield, J.; King, N.
10.1101/2021.03.30.437421 — microbiology — Posted on 2021-11-10
2564 Human gut derived Anaerotruncus colihominis ameliorates experimental autoimmune encephalomyelitis
Bianchimano, P.; Britton, G. J.; Wallach, d.; Smith, E.; Cox, L.; Liu, S.; Weiner, H.; Faith, J. J.; Clemente, J. C.; Tankou, S.
10.1101/2021.11.10.468120 — microbiology — Posted on 2021-11-10
2565 Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation
Ualiyeva, S.; Lemire, E. R.; Aviles, E. C.; Boyd, A.; Wong, C.; Lai, J.; Liu, T.; Matsumoto, I.; Barrett, N. A.; Boyce, J. A.; Haber, A. L.; Bankova, L.
10.1101/2021.09.26.461888 — immunology — Posted on 2021-11-10
2566 Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection
Parsa, R.; London, M.; Rezende de Castro, T. B.; Reis, B.; Buissant des Amorie, J.; Smith, J. G.; Mucida, D.
10.1101/2021.11.10.468106 — immunology — Posted on 2021-11-10
2567 Reorganization of thalamocortical connections in congenitally blind humans
Marins, T.; Russo, M.; Rodrigues, E.; Monteiro, M.; Moll, J.; Felix, D.; Bouzas, J.; Arcanjo, H.; Vargas, C. D.; Tovar-Moll, F.
10.1101/449009 — neuroscience — Posted on 2021-11-10
2571 Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial-mesenchymal transition in culture
Ruiter, F. A. A.; Morgan, F. L. C.; Roumans, N.; Schumacher, A.; Slaats, G. G.; Moroni, L.; LaPointe, V. L. S.; Baker, M. B.
10.1101/2021.11.10.467741 — bioengineering — Posted on 2021-11-10
2573 An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell
Gangopadhyay, K.; Roy, A.; Chandradasan, A.; Roy, S.; Debnath, O.; SenGupta, S.; Chowdhury, S.; Das, D.; Das, R.
10.1101/2021.11.09.467998 — biochemistry — Posted on 2021-11-10
2575 Improvement of eukaryotic proteins prediction from soil metagenomes
Belliardo, C.; Koutsovoulos, G.; Rancurel, C.; Clement, M.; Lipuma, J.; Bailly-Bechet, M.; Danchin, E. G. J.
10.1101/2021.11.10.468086 — genomics — Posted on 2021-11-10
2577 Intrasexual cuticular hydrocarbon dimorphism in a wasp sheds light on hydrocarbon biosynthesis genes in Hymenoptera
Moris, V. C.; Podsiadlowski, L.; Martin, S.; Oeyen, J. P.; Donath, A.; Petersen, M.; Wilbrandt, J.; Misof, B.; Liedtke, D.; Thamm, M.; Scheiner, R.; Schmitt, T.; Niehuis, O.
10.1101/2021.11.10.467931 — molecular biology — Posted on 2021-11-10
2580 Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus
Gultom, M.; Kratzel, A.; Portmann, J.; Stalder, H.; Baetzner, A. C.; Gantenbein, H.; Gurtner, C.; Ebert, N.; Posthaus, H.; Zanolari, P.; Pfaender, S.; Thiel, V.; Dijkman, R.
10.1101/2021.11.10.468038 — microbiology — Posted on 2021-11-10
2583 YAP1 Activation by Human Papillomavirus E7 Promotes Basal Cell Identity in Squamous Epithelia
Hatterschide, J.; Castagnino, P.; Kim, H. W.; Sperry, S. M.; Montone, K. T.; Basu, D.; White, E. A.
10.1101/2021.11.10.468068 — microbiology — Posted on 2021-11-10
2584 Chromosome-encoded IpaH ubiquitin ligases indicate non-human pathogenic Escherichia
Dranenko, N. O.; Tutukina, M.; Gelfand, M. S.; Kondrashov, F.; Bochkareva, O. O.
10.1101/2021.10.19.464960 — microbiology — Posted on 2021-11-10
2585 tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector
Jain, I.; Kolesnik, M.; Minakhin, L.; Morozova, N.; Shiriaeva, A.; Kirillov, A.; Medvedeva, S.; Kuznedelov, K.; Borukhov, S.; Makarova, K. S.; Koonin, E. V.; Severinov, K.; Semenova, E.
10.1101/2021.11.10.468108 — microbiology — Posted on 2021-11-10
2586 Beyond Spike: Identification of nine highly prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a large Norwegian cohort
Meyer, S.; Blaas, I.; Bollineni, R. C.; Delic-Sarac, M.; Tran, T. T.; Knetter, C.; Dai, K.-Z.; Stove Madssen, T.; Vaage, J. T.; Gustavsen, A.; Yang, W.; Haug Nissen-Meyer, L. S.; Douvlataniotis, K.; Laos, M.; Nielsen, M. M.; Thiede, B.; Soraas, A.; Lund-Johansen, F.; Rustad, E. H.; Olweus, J.
10.1101/2021.10.13.463911 — immunology — Posted on 2021-11-10
2587 Broca areas' asymmetry reflects gestural communication lateralisation in monkeys (Papio anubis)
Becker, Y.; Claidiere, N.; Margiotoudi, K.; Marie, D.; Roth, M.; Nazarian, B.; Lacoste, R.; Anton, J.-L.; Coulon, O.; Meguerditchian, A.
10.1101/2021.02.09.430276 — neuroscience — Posted on 2021-11-10
2588 Gender Imbalance in the Editorial Activities of a Researcher-led Journal
Seidel Malkinson, T.; Terhune, D. B.; Kollamkulam, M.; Guerreiro, M. J.; Bassett, D. S.; Makin, T. R.
10.1101/2021.11.09.467796 — scientific communication and education — Posted on 2021-11-10
2589 On-tissue spatial proteomics integrating MALDI-MS imaging with shotgun proteomics reveals soy consumption-induced biomarkers in a fragile X syndrome mouse model
Li, l.; MA, M.; Yu, Q.; Delafield, D. G.; Cui, Y.; Li, Z.; Wu, W.; Shi, X.; Gutierrez, A.; Westmark, P. R.; Xu, M.; Westmark, C. J.
10.1101/2021.11.09.467989 — biochemistry — Posted on 2021-11-10
2590 Potent antibody immunity to SARS-CoV-2 variants elicited by a third dose of inactivated vaccine
Ju, B.; Zhou, B.; Song, S.; Fan, Q.; Ge, X.; Wang, H.; Cheng, L.; Guo, H.; Shu, D.; Liu, L.; Zhang, Z.
10.1101/2021.11.10.468037 — immunology — Posted on 2021-11-10
2592 LRRC15 suppresses SARS-CoV-2 infection and controls collagen production
Loo, L.; Waller, M. A.; Cole, A. J.; Stella, A. O.; Moreno, C. L.; Denes, C. E.; Hamoudi, Z.; Chung, F.; Aggarwal, A.; Low, J. K. K.; Patel, K.; Siddique, R.; Mackay, J.; Turville, S.; Hesselson, D.; Neely, G. G.
10.1101/2021.11.09.467981 — cell biology — Posted on 2021-11-10
2594 The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variant
Lista, M. J.; Winstone, H.; Wilson, H.; Dyer, A.; Pickering, S.; Galao, R. P.; De Lorenzo, G.; Cowton, V.; Furnon, W.; Suarez, N. M.; Orton, R.; Palmarini, M.; Patel, A. H.; Snell, L. B.; Nebbia, G.; Swanson, C. M.; Neil, S.
10.1101/2021.11.09.467693 — microbiology — Posted on 2021-11-10
2600 Design of D-amino acids SARS-CoV-2 Main protease inhibitors using the cationic peptide from rattlesnake venom as a scaffold
Eberle, R. J.; Gering, I.; Tusche, M.; Ostermann, P. N.; Mueller, L.; Adams, O.; Schaal, H.; Olivier, D. S.; Amaral, M. S.; Arni, R. K.; Willbold, D.; Coronado, M.
10.1101/2021.11.10.468025 — biochemistry — Posted on 2021-11-10
2601 Interpreting ruminant specific conserved non-coding elements by developmental gene regulatory network
Pan, X.; Ma, Z.; Sun, X.; Li, H.; Zhang, T.; Zhao, C.; Wang, N.; Heller, R.; Wong, W. H.; Wang, W.; Jiang, Y.; Wang, Y.
10.1101/2021.11.08.467829 — genomics — Posted on 2021-11-10
2602 Comparison of materials for rapid passive collection of environmental DNA
Bessey, C.; Gao, Y.; Truong, Y. B.; Miller, H.; Jarman, S. N.; Berry, O.
10.1101/2021.11.08.467842 — ecology — Posted on 2021-11-10
2606 Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
Rosas Mejia, O.; Gloag, E.; Li, J.; Ruane-Foster, M.; Claeys, T. A.; Farkas, D.; Farkas, L.; Xin, G.; Robinson, R.
10.1101/2021.11.09.467862 — immunology — Posted on 2021-11-10
2607 Individual differences in frontoparietal plasticity in humans
Boroshok, A. L.; Park, A. T.; Fotiadis, P.; Velasquez, G. H.; Tooley, U. A.; Simon, K. R.; Forde, J. C. P.; Delgado Reyes, L. M.; Tisdall, M. D.; Bassett, D. S.; Cooper, E. A.; Mackey, A. P.
10.1101/2021.11.08.467831 — neuroscience — Posted on 2021-11-10
2608 Bedtime to the brain: How infants sleep habits intertwine with sleep neurophysiology
Schoch, S. F.; Jaramillo, V.; Markovic, A.; Huber, R.; Kohler, M.; Jenni, O. G.; Lustenberger, C.; Kurth, S.
10.1101/2021.11.08.467800 — neuroscience — Posted on 2021-11-10
2611 mTOR Inhibition Overcomes RSK3-mediated Resistance to BET Inhibitors in Small Cell Lung Cancer
Kumari, A.; Gesumaria, L.; Liu, Y.-J.; Hughitt, V. K.; Zhang, X.; Ceribelli, M.; Wilson, K. M.; Klumpp-Thomas, C.; Chen, L.; McKnight, C.; Itkin, Z.; Thomas, C.; Mock, B. A.; Schrump, D. S.; Chen, H.
10.1101/2021.11.08.467833 — cancer biology — Posted on 2021-11-10
2615 Prospects of telomere-to-telomere assembly in barley: analysis of sequence gaps in the MorexV3 reference genome
Navratilova, P.; Toegelova, H.; Tulpova, Z.; Kuo, Y.-T.; Stein, N.; Dolezel, J.; Houben, A.; Simkova, H.; Mascher, M.
10.1101/2021.11.08.467736 — genomics — Posted on 2021-11-10
2616 Gene recruitments and dismissals in argonaut octopus genome provide insights to pelagic lifestyle adaptation and shell-like eggcase reacquisition
Yoshida, M.-a.; Hirota, K.; Imoto, J.; Okuno, M.; Tanaka, H.; Kajitani, R.; Toyoda, A.; Itoh, T.; Ikeo, K.; Sasaki, T.; Setiamarga, D. H.
10.1101/2021.11.08.467834 — genomics — Posted on 2021-11-10
2617 Longitudinal immune cell profiling in early systemic lupus erythematosus
Sasaki, T.; Bracero, S.; Keegan, J.; Chen, L.; Cao, Y.; Stevens, E.; Qu, Y.; Wang, G.; Nguyen, J.; Alves, S. E.; Lederer, J. A.; Costenbader, K. H.; Rao, D. A.
10.1101/2021.11.08.467791 — immunology — Posted on 2021-11-10
2620 Cerebral perfusion imaging: Hypoxia-induced deoxyhemoglobin or gadolinium?
Sayin, E. S.; Schulman, J.; Poublanc, J.; Levine, H.; Venkatraghavan, L.; Uludag, K.; Duffin, J.; Fisher, J. A.; Mikulis, D. J.; Sobczyk, O.
10.1101/2021.11.08.467772 — neuroscience — Posted on 2021-11-10
2621 Identifying Causal Subsequent Memory Effects
Halpern, D. J.; Tubridy, S.; Davachi, L.; Gureckis, T. M.
10.1101/2021.11.08.467782 — neuroscience — Posted on 2021-11-10
2623 Correcting Cardiorespiratory Noise in Resting-state Functional MRI Data Acquired in Critically Ill Patients
Chan, S.-t.; Sanders, W. R.; Fischer, D. J.; Kirsch, J. E.; Napadow, V.; Bodien, Y. G.; Edlow, B. L.
10.1101/2021.11.08.467753 — neuroscience — Posted on 2021-11-10
2629 WATLAS: high resolution and real-time tracking of many small birds in the Dutch Wadden Sea
Bijleveld, A. I.; van Maarseveen, F.; Denissen, B.; Dekinga, A.; Penning, E.; Ersoy, S.; Gupte, P.; de Monte, L.; ten Horn, J.; Bom, R.; Toledo, S.; Nathan, R.; Beardsworth, C.
10.1101/2021.11.08.467683 — ecology — Posted on 2021-11-10
2630 Iterative community-driven development of a SARS-CoV-2 tissue simulator
Getz, M.; Wang, Y.; An, G.; Asthana, M.; Becker, A.; Cockrell, C.; Collier, N.; Craig, M.; Davis, C. L.; Faeder, J. R.; Ford Versypt, A. N.; Mapder, T.; Gianlupi, J. F.; Glazier, J. A.; Hamis, S.; Heiland, R.; Hillen, T.; Hou, D.; Islam, M. A.; Jenner, A. L.; Kurtoglu, F.; Larkin, C. I.; Liu, B.; Macfarlane, F.; Maygrundter, P.; Morel, P. A.; Narayanan, A.; Ozik, J.; Pienaar, E.; Rangamani, P.; Saglam, A. S.; Shoemaker, J. E.; Smith, A. M.; Weaver, J. J. A.; Macklin, P.
10.1101/2020.04.02.019075 — systems biology — Posted on 2021-11-10
2631 Hyperbolic trade-off: the importance of balancing trial and subject sample sizes in neuroimaging
Chen, G.; Pine, D. S.; Brotman, M. A.; Smith, A. R.; Cox, R. W.; Taylor, P. A.; Haller, S. P.
10.1101/2021.07.15.452548 — neuroscience — Posted on 2021-11-10
2632 tACS phase-specifically biases brightness perception of flickering light
Fiene, M.; Radecke, J.-O.; Misselhorn, J.; Sengelmann, M.; Herrmann, C. S.; Schneider, T. R.; Schwab, B. C.; Engel, A. K.
10.1101/2021.06.26.450021 — neuroscience — Posted on 2021-11-10
2633 Photoprotection is regulated by light-independent CO2 availability
Ruiz-Sola, M. A.; Flori, S.; Yuan, Y.; Villain, G.; Sanz-Luque, E.; Redekop, P.; Tokutsu, R.; Küken, A.; Tsichla, A.; Kepesidis, G.; Allorent, G.; Arend, M.; Iacono, F.; Finazzi, G.; Hippler, M.; Nikoloski, Z.; Minagawa, J.; Grossman, A. R.; Petroutsos, D.
10.1101/2021.10.23.465040 — plant biology — Posted on 2021-11-10
2638 Cohort Profile: Genetic data in the German Socio-Economic Panel Innovation Sample (Gene-SOEP)
Koellinger, P. D.; Okbay, A.; Kweon, H.; Schweinert, A.; Karlsson Linner, R.; Goebel, J.; Richter, D.; Reiber, L.; Zweck, B. M.; Belsky, D.; Biroli, P.; Mata, R.; Tucker-Drob, E. M.; Harden, K. P.; Wagner, G.; Hertwig, R.
10.1101/2021.11.06.467573 — genetics — Posted on 2021-11-10
2639 Competitive asymmetry confers polyploid advantage under environmental stress
Guo, W.; Wei, N.; Hao, G.-Y.; Yang, S.-J.; Zhu, Z.-Y.; Yang, Y.-P.; Duan, Y.-W.
10.1101/2021.11.08.467667 — ecology — Posted on 2021-11-10
2641 Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition
Pacheco-Moreno, A.; Stefanato, F. L.; Ford, J. J.; Trippel, C.; Uszkoreit, S.; Ferrafiat, L.; Grenga, L.; Dickens, R.; Kelly, N.; Kingdon, A. D.; Ambrosetti, L.; Nepogodiev, S. A.; Findlay, K. C.; Cheema, J.; Trick, M.; Chandra, G.; Tomalin, G.; Malone, J. G.; Truman, A. W.
10.1101/783258 — microbiology — Posted on 2021-11-10
2644 Intra-individual Physiomic Landscape of Pyramidal Neurons in the Human Neocortex
Planert, H.; Mittermaier, F. X.; Grosser, S.; Fidzinski, P.; Schneider, U. C.; Radbruch, H.; Onken, J.; Holtkamp, M.; Schmitz, D.; Alle, H.; Vida, I.; Geiger, J. R. P.; Peng, Y.
10.1101/2021.11.08.467668 — neuroscience — Posted on 2021-11-10
2646 Multi-parametric characterization of brain-wide hemodynamic and calcium responses to sensory stimulation in mice
Chen, Z.; Zhou, Q.; Dean-Ben, X. L.; Gezginer, I.; Ni, R.; Reiss, M.; Shoham, S.; Razansky, D.
10.1101/2021.11.08.467725 — neuroscience — Posted on 2021-11-10
2647 Sources of variation in the spectral slope of the sleep EEG
Kozhemiako, N.; Mylonas, D.; Pan, J. Q.; Prerau, M. J.; Redline, S.; Purcell, S. M.
10.1101/2021.11.08.467763 — neuroscience — Posted on 2021-11-10
2648 Posterior integration and thalamo-frontotemporal broadcasting are impaired in disorders of consciousness
Panda, R.; Lopez-Gonzalez, A.; Gilson, M.; Gosseries, O.; Thibaut, A.; Frasso, G.; Cecconi, B.; Escrichs, A.; GIGA group collaborators, ; Deco, G.; Laureys, S.; Zamora-Lopez, G.; Annen, J.
10.1101/2021.11.08.467694 — neuroscience — Posted on 2021-11-10
2651 Microtubule Lattice Spacing Governs Cohesive Envelope Formation of Tau Family Proteins
Siahaan, V.; Tan, R.; Humhalova, T.; Libusova, L.; Lacey, S. E.; Tan, T.; Dacy, M.; Ori-McKenney, K. M.; McKenney, R. J.; Braun, M.; Lansky, Z.
10.1101/2021.11.08.467404 — biophysics — Posted on 2021-11-10
2654 Diversity and evolution of nitric oxide reduction
Murali, R.; Pace, L. A.; Sanford, R. A.; Ward, L.; Lynes, M.; Hatzenpichler, R.; Lingappa, U.; Fischer, W. W.; Gennis, R. B.; Hemp, J.
10.1101/2021.10.15.464467 — biochemistry — Posted on 2021-11-10
2658 Delineation of dynorphin and kappa opioid receptor circuit elements in alcohol consumption
Pina, M.; Pati, D.; Neira, S.; Stanhope, C.; Mahoney, A.; D'Ambrosio, S.; kash, t.; Navarro, M.
10.1101/2021.11.09.467893 — neuroscience — Posted on 2021-11-10
2659 TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death
Yu, D.; Song, W.; Tan, E. Y. J.; Liu, L.; Cao, Y.; Jirschitzka, J.; Li, E.; Logemann, E.; Xu, C.; Huang, S.; Jia, A.; Chang, X.; Han, Z.; Wu, B.; Schulze-Lefert, P.; Chai, J.
10.1101/2021.11.09.467869 — plant biology — Posted on 2021-11-10
2662 Non-invasive imaging of gene expression and protein secretion dynamics in living mice: identification of ectopic prothrombin expression as driver of thrombosis in cancer
Nourse, J.; Tokalov, S.; Khokhar, S.; Khan, E.; Schott, L. K.; Hinz, L.; Eder, L.; Arnold-Schild, D.; Satrapa, J.; Lackner, K. J.; Ten Cate, H.; Probst, H. C.; Danckwardt, S.
10.1101/2021.07.08.451623 — genetics — Posted on 2021-11-10
2667 RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer
Miao, c.; Tsujino, T.; Takai, T.; Fu, G.; Tsutsumi, T.; Sztupinszki, Z.; Szallasi, Z.; Mouw, K. W.; Kibel, A. S.; Jia, L.
10.1101/2021.11.08.467839 — cancer biology — Posted on 2021-11-10
2668 Spontaneous differentiation leads to emergence of hybrid cell states relate to poor prognosis in oral cancer
Vipparthi, K.; Hari, K.; Chakraborty, P.; Ghosh, S.; Patel, A.; Ghosh, A.; Biswas, N. K.; Sharan, R.; Arun, P.; Jolly, M. K.; Singh, S.
10.1101/2021.08.24.457509 — cancer biology — Posted on 2021-11-10
2669 Large-scale conformational changes of FhaC provide insights into the two-partner secretion mechanism
Sicoli, G.; Konijnenberg, A.; Guerin, J.; Hessmann, S.; Del Nero, E.; Hernandez-Alba, O.; Lecher, S.; Rouaut, G.; Mueggenburg, L.; Vezin, H.; CIANFERANI, S.; Sobott, F.; Schneider, R.; Jacob-Dubuisson, F.
10.1101/2021.11.09.467682 — biophysics — Posted on 2021-11-10
2674 The beryllium fluoride form of the Na+,K+-ATPase and the intermediates of the functional cycle
Nissen, P.; Fruergaard, m. U.; Fedosova, N. U.; Andersen, J. L.; Shahsavar, A.; Quistgaard, E.; Poulsen, H.; Dach, I.
10.1101/2021.11.08.467847 — biochemistry — Posted on 2021-11-10
2675 Transcriptome analysis of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine
Zhang, Y.; Guo, X.; Li, C.; Kou, Z.; Lin, L.; Yao, M.; Pang, B.; Zhang, X.; Duan, Q.; Tian, X.; Xing, Y.; Jiang, X.
10.1101/2021.11.05.467537 — microbiology — Posted on 2021-11-10
2681 Chromosome-level de novo genome assembly of Telopea speciosissima (New South Wales waratah) using long-reads, linked-reads and Hi-C
Chen, S. H.; Rossetto, M.; van der Merwe, M.; Lu-Irving, P.; Yap, J.-Y. S.; Sauquet, H.; Bourke, G.; Amos, T. G.; Bragg, J. G.; Edwards, R. J.
10.1101/2021.06.02.444084 — genomics — Posted on 2021-11-10
2682 A macromutation eliminates colour patterning in captive butterflies
Hanly, J. J.; Livraghi, L.; Heryanto, C.; McMillan, W. O.; Jiggins, C. D.; Gilbert, L. E.; Martin, A.
10.1101/2021.10.29.466422 — genetics — Posted on 2021-11-10
2687 ORP5/8 AND MIB/MICOS LINK ER-MITOCHONDRIA AND INTRAMITOCHONDRIAL CONTACTS FOR NON-VESICULAR TRANSPORT OF PHOSPHATIDYLSERINE
Rochin, L.; Monteiro-Cardoso, V. F.; Arora, A.; Houcine, A.; Jaaskelainen, E.; Kivela, A. M.; Sauvanet, C.; Le Bars, R.; Marien, E.; Dehairs, J.; Neveu, J.; El Khallouki, N.; Santonico, E.; Swinnen, J. V.; Tareste, D.; Olkkonen, V. M.; Giordano, F.
10.1101/695577 — cell biology — Posted on 2021-11-10
2691 Uncovering the Organization of Neural Circuits with Generalized Phase Locking Analysis
Safavi, S.; Panagiotaropoulos, T. I.; Kapoor, V.; Ramirez-Villegas, J. F.; Logothetis, N. K.; Besserve, M.
10.1101/2020.12.09.413401 — neuroscience — Posted on 2021-11-10
2692 A transcriptomic axis predicts state modulation of cortical interneurons
Bugeon, S.; Duffield, J.; Dipoppa, M.; Ritoux, A.; Prankerd, I.; Nicoloutsopoulos, D.; Orme, D.; Shinn, M.; Peng, H.; Forrest, H.; Viduolyte, A.; Bai Reddy, C.; Isogai, Y.; Carandini, M.; Harris, K. D.
10.1101/2021.10.24.465600 — neuroscience — Posted on 2021-11-10
2693 Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency
Dugger, S. A.; Dhindsa, R. S.; De Almeida Sampaio, G.; Ressler, A. K.; Rafikian, E. E.; Petri, S.; Letts, V. A.; Teoh, J.; Ye, J.; Colombo, S.; Yang, M.; Boland, M. J.; Frankel, W. N.; Goldstein, D. B.
10.1101/2020.05.01.072512 — neuroscience — Posted on 2021-11-10
2696 FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma
Orstad, G.; Jones, A.; Parnell, T. J.; Fort, G.; Lohman, B.; Gillis, K. L.; Klingbeil, O.; Kaestner, K. H.; Vakoc, C.; Snyder, E. L.
10.1101/2021.06.29.450247 — cancer biology — Posted on 2021-11-10
2697 BayesDeBulk: A Flexible Bayesian Algorithm for the Deconvolution of Bulk Tumor Data
Petralia, F.; Calinawan, A. P.; Feng, S.; Gosline, S. J.; Pugliese, P.; Ceccarelli, M.; Wang, P.
10.1101/2021.06.25.449763 — bioinformatics — Posted on 2021-11-10
2701 High coverage whole genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios
Byrska-Bishop, M.; Evani, U. S.; Zhao, X.; Basile, A. O.; Abel, H. J.; Regier, A. A.; Corvelo, A.; Clarke, W. E.; Musunuri, R.; Nagulapalli, K.; Fairley, S.; Runnels, A.; Winterkorn, L.; Lowy, E.; The Human Genome Structural Variation Consortium, ; Flicek, P.; Germer, S.; Brand, H.; Hall, I. M.; Talkowski, M. E.; Narzisi, G.; Zody, M. C.
10.1101/2021.02.06.430068 — genomics — Posted on 2021-11-10
2704 Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
Diaz-Salinas, M. A.; Li, Q.; Ejemel, M.; Yurkovetskiy, L.; Luban, J.; Shen, K.; Wang, Y.; Munro, J. B.
10.1101/2021.10.29.466470 — biophysics — Posted on 2021-11-09
2707 Salmonella Outer Membrane Vesicles contain tRNA Fragments (tRFs) that Inhibit Bacteriophage P22 infection
Houserova, D.; Huang, Y.; Kasukurthi, M. V.; Watters, B. C.; Khan, F. F.; Mehta, R. V.; Chaudhary, N. Y.; Roberts, J. T.; DeMeis, J. D.; Hobbs, T. K.; Ghee, K. R.; McInnis, C. H.; Johns, N. P.; Kegler, A. J.; Coley, A. B.; Brown, C. L.; Hewes, J. L.; McElyea, M. M.; Reeves, M. N.; Tran, T. M.; Bauer, N. R.; Huang, J.; Audia, J. P.; Foster, J. W.; Borchert, G. M.
10.1101/2021.11.09.467952 — microbiology — Posted on 2021-11-09
2708 Platelets are dispensable for the ability of CD8+ T cells to accumulate, patrol, kill and reside in the liver
O'Connor, J. H.; McNamara, H. A.; Cai, Y.; Coupland, L. A.; Gardiner, E. E.; Parish, C. R.; McMorran, B. J.; Ganusov, V. V.; Cockburn, I. A.
10.1101/2021.11.09.467964 — immunology — Posted on 2021-11-09
2710 Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics
Mitchell, W.; Tamucci, J.; Ng, E.; Liu, S.; Szeto, H. H.; May, E. R.; Alexandrescu, A.; Alder, N. N.
10.1101/2021.11.08.467832 — biochemistry — Posted on 2021-11-09
2716 Host-associated phages disperse across the extraterrestrial analogue Antarctica
Rahlff, J.; Bornemann, T. L. V.; Lopatina, A.; Severinov, K.; Probst, A. J.
10.1101/2021.11.09.467789 — microbiology — Posted on 2021-11-09
2717 Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis
Servaas, N. H.; Hiddingh, S.; Chouri, E.; Wichers, C. G. K.; Affandi, A. J.; Ottria, A.; Bekker, C. P. J.; Cossu, M.; Silva-Cardoso, S.; van der Kroef, M.; Hinrichs, A. C.; Carvalheiro, T.; Vazirpanah, N.; Beretta, L.; Rossato, M.; Bonte-Minheur, F.; Radstake, T. R. D. J.; Kuiper, J. J. W.; Boes, M.; Pandit, A.
10.1101/2021.11.08.467605 — immunology — Posted on 2021-11-09
2718 Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43
Heo, D.; Ling, J. P.; Molina-Castro, G. C.; Langseth, A. J.; Waisman, A.; Nave, K.-A.; Moebius, W.; Wong, P. C.; Bergles, D. E.
10.1101/2021.11.09.467933 — neuroscience — Posted on 2021-11-09
2721 Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors
Ruiz, A.; Benucci, S.; Duthaler, U.; Bachmann, C. P.; Franchini, M.; Noreen, F.; Pietrangelo, L.; Protasi, F.; Treves, S.; Zorzato, F.
10.1101/2021.11.09.467894 — physiology — Posted on 2021-11-09
2724 Assessing and enhancing foldability in designed proteins
Fleishman, S. J.; Listov, D.; Lipsh-Sokolik, R.; Yang, C.; Correia, B. E.
10.1101/2021.11.09.467863 — biochemistry — Posted on 2021-11-09
2725 Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation
Vasanthakumar, T.; Keon, K. A.; Bueler, S. A.; Jaskolka, M. C.; Rubinstein, J. L.
10.1101/2021.11.09.467972 — biochemistry — Posted on 2021-11-09
2727 Natural variation in gene expression and Zika virus susceptibility revealed by villages of neural progenitor cells
Wells, M. F.; Nemesh, J.; Ghosh, S.; Mitchell, J. M.; Mello, C. J.; Meyer, D.; Raghunathan, K.; Tegtmeyer, M.; Hawes, D.; Neumann, A.; Worringer, K. A.; Raymond, J. J.; Kommineni, S.; Chan, K.; Ho, D.; Peterson, B. K.; Piccioni, F.; Nehme, R. F.; Eggan, K.; McCarroll, S. A.
10.1101/2021.11.08.467815 — genomics — Posted on 2021-11-09
2729 Novel genetic basis of resistance to Bt toxin Cry1Ac in Helicoverpa zea
Benowitz, K. M.; Allan, C. W.; Degain, B. A.; Li, X.; Fabrick, J. A.; Tabashnik, B. E.; Carriere, Y.; Matzkin, L. M.
10.1101/2021.11.09.467966 — genetics — Posted on 2021-11-09
2730 Mitochondria transplantation between living cells
Gäbelein, C. G.; Feng, Q.; Sarajlic, E.; Zambelli, T.; Guillaume-Gentil, O.; Kornmann, B.; Vorholt, J. A.
10.1101/2021.11.09.467932 — cell biology — Posted on 2021-11-09
2732 Factors Influencing the Detection of Antibacterial Resistant Escherichia coli in Faecal Samples from Individual Cattle
Turner, A.; Schubert, H.; Puddy, E. F.; Sealey, J. E.; Gould, V. C.; Cogan, T. A.; Avison, M. B.; Reyher, K. K.
10.1101/2021.11.07.467618 — microbiology — Posted on 2021-11-09
2736 A self-amplifying mRNA COVID-19 vaccine drives potent and broad immune responses at low doses that protects non-human primates against SARS-CoV-2
Rappaport, A. R.; Hong, S.-J.; Scallan, C. D.; Gitlin, L.; Akoopie, A.; Boucher, G. R.; Egorova, M.; Espinosa, J. A.; Fidanza, M.; Kachura, M. A.; Shen, A.; Sivko, G.; Van Abbema, A.; Veres, R. L.; Jooss, K.
10.1101/2021.11.08.467773 — immunology — Posted on 2021-11-09
2738 Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease
Davenport, B. J.; Catala, A.; Weston, S. M.; Johnson, R. M.; Ardunay, J.; Hammond, H. L.; Dillen, C.; Frieman, M. B.; Catalano, C. E.; Morrison, T. E.
10.1101/2021.11.08.467648 — immunology — Posted on 2021-11-09
2739 Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
Lee, K. J.; Rambault, L.; Bou-Gharios, G.; Clegg, P. D.; Akhtar, R.; Czanner, G.; van 't Hof, R. J.; Canty-Laird, E. G.
10.1101/2020.07.13.198283 — physiology — Posted on 2021-11-09
2741 Extensive transgressive gene expression in testis but not ovary in the homoploid hybrid Italian sparrow
Papoli Yazdi, H.; Ravinet, M.; Rowe, M.; Saetre, G.-P.; Oien Guldvog, C.; Eroukhmanoff, F.; Marzal, A.; Magallanes, S.; Runemark, A.
10.1101/2021.04.15.440043 — evolutionary biology — Posted on 2021-11-09
2742 TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
Sivakumar, S.; Qi, S.; Cheng, N.; sathe, A. a.; Kanchwala, M.; Kumar, A.; Evers, B. M.; Xing, C.; Yu, H.
10.1101/2021.07.22.453348 — developmental biology — Posted on 2021-11-09
2744 inPOSE: a flexible toolbox for chromosomal cloning and amplification of bacterial transgenes
Shukla, R. D.; Zvara, A.; Avramucz, A.; Biketova, A. Y.; Nyerges, A.; Puskas, L. G.; Feher, T.
10.1101/2021.10.28.466346 — synthetic biology — Posted on 2021-11-09
2746 Towards a structurally resolved human protein interaction network
Burke, D. F.; Bryant, P.; Barrio-Hernandez, I.; Memon, D.; Pozzati, G.; Shenoy, A.; Zhu, W.; Dunham, A. S.; Albanese, P.; Keller, A.; Scheltema, R. A.; Bruce, J. B.; Leitner, A.; Kundrotas, P.; Beltrao, P.; Elofsson, A.
10.1101/2021.11.08.467664 — bioinformatics — Posted on 2021-11-09
2747 CRISPR-Cas9 mediated nuclear transport and genomic integration of nanostructured genes in human primary cells
Lin Shiao, E.; Pfeifer, W. G.; Shy, B. R.; Doost, M. S.; Chen, E.; Vykunta, V. S.; Hamilton, J. R.; Stahl, E. C.; Lopez, D. M.; Espinoza, C. R. S.; Dejanov, A. E.; Lew, R. J.; Poirer, M. G.; Marson, A.; Castro, C. E.; Doudna, J. A.
10.1101/2021.11.08.467750 — bioengineering — Posted on 2021-11-09
2748 Context-dependent inversion of the response in a single sensory neuron type reverses olfactory preference behavior
Khan, M.; Hartmann, A. H.; O'Donnell, M. P.; Piccione, M.; Chao, P.-H.; Dwyer, N. D.; Bargmann, C. I.; Sengupta, P.
10.1101/2021.11.08.467792 — neuroscience — Posted on 2021-11-09
2749 An active learning framework improves tumor variant interpretation
Blee, A. M.; Li, B.; Pecen, T.; Meiler, J.; Nagel, Z. D.; Capra, J. A.; Chazin, W. J.
10.1101/2021.11.08.467747 — cancer biology — Posted on 2021-11-09
2750 Protein sequence sampling and prediction from structural data
Orellana, G. A.; Caceres-Delpiano, J.; Ibanez, R.; Dunne, M. P.; Alvarez, L.
10.1101/2021.09.06.459171 — bioinformatics — Posted on 2021-11-09
2757 Energy metabolism adaptations and gene expression reprogramming in a cellular MAFLD model
Zhou, T.-R.; Cömert, C.; Zhou, X.; Lin, L.; Bolund, L.; Palmfeldt, J.; Tong, G.; Luo, Y.; Bross, P.
10.1101/2021.11.08.467719 — cell biology — Posted on 2021-11-09
2759 Unifying the known and unknown microbial coding sequence space
Vanni, C.; Schechter, M. S.; Acinas, S.; Barberan, A.; Buttigieg, P. L.; Casamayor, E. O.; Delmont, T. O.; Duarte, C. M.; Eren, A. M.; Finn, R. D.; Kottmann, R.; Mitchell, A.; Sanchez, P.; Siren, K.; Steinegger, M.; Glöckner, F. O.; Fernandez-Guerra, A.
10.1101/2020.06.30.180448 — microbiology — Posted on 2021-11-09
2761 Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Ibanez, K.; McFarland, K.; Phillips, J.; Allen, M.; Lessard, C. B.; Zobel, L.; Gonzalez De La Cruz, E.; Shah, S.; Vo, Q.; Wang, X.; Quicksall, Z.; Ryu, D.; Funk, C.; Ertekin-Taner, N.; Prokop, S.; Golde, T.; Chakrabarty, P.
10.1101/2021.11.08.467701 — neuroscience — Posted on 2021-11-09
2763 Using temperature to analyse the neural basis of a latent temporal decision
Monteiro, T.; Rodrigues, F. S.; Pexirra, M.; Cruz, B. F. P.; Goncalves, A. I.; Rueda-Orozco, P. E.; Paton, J. J.
10.1101/2020.08.24.251827 — neuroscience — Posted on 2021-11-09
2764 Large-scale discovery of recombinases for integrating DNA into the human genome
Durrant, M. G.; Fanton, A.; Tycko, J.; Hinks, M.; Chandrasekaran, S. S.; Perry, N. T.; Schaepe, J.; Du, P. P.; Lotfy, P.; Bassik, M. C.; Bintu, L.; Bhatt, A. S.; Hsu, P. D.
10.1101/2021.11.05.467528 — bioengineering — Posted on 2021-11-09
2765 Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury
Li, D. K.; Chaudhari, S. N.; Sojoodi, M.; Li, Y.; Adhikari, A. A.; Zukerberg, L.; Shroff, S.; Barrett, S. C.; Tanabe, K.; Chung, R. T.; Devlin, A. S.
10.1101/2021.03.24.436896 — physiology — Posted on 2021-11-09
2768 Humans hastened the range collapse and extinction of woolly mammoth
Fordham, D. A.; Brown, S. C.; Akcakaya, H. R.; Brook, B. W.; Haythorne, S.; Manica, A.; Shoemaker, K. T.; Austin, J. J.; Blonder, B.; Pilowsky, J.; Rahbek, C.; Nogues-Bravo, D.
10.1101/2021.02.17.431706 — ecology — Posted on 2021-11-09
2772 Discrete-to-analog signal conversion in human pluripotent stem cells
Prochazka, L.; Michaels, Y. S.; Lau, C.; Siu, M.; Yin, T.; Wu, D.; Jang, E.; Jones, R. D.; Vazquez-Cantu, M.; Gilbert, P. M.; Kaul, H.; Benenson, Y.; Zandstra, P. W.
10.1101/2021.11.05.467377 — synthetic biology — Posted on 2021-11-09
2775 Central and peripheral delivery of AAV9-SMN target different pathomechanisms in a mouse model of spinal muscular atrophy
Reilly, A. N.; Deguise, M.; Beauvais, A.; Yaworski, R.; Thebault, S.; Tessier, D. R.; Tabard-Cossa, V.; Hensel, N.; Schneider, B. L.; Kothary, R.
10.1101/2021.11.08.467795 — molecular biology — Posted on 2021-11-08
2776 Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium
Rusu, I.; Mennillo, E.; Bain, J. L.; Li, Z.; Sun, X.; Ly, K.; Rosli, Y. Y.; Naser, M.; Wang, Z.; Advincula, R.; Achacoso, P.; Shao, L.; Razani, B.; Klein, O. D.; Marson, A.; Turnbaugh, J.; Turnbaugh, P.; Malynn, B. A.; Ma, A.; Kattah, M. G.
10.1101/2021.11.08.467808 — immunology — Posted on 2021-11-08
2777 Minimal phrase composition revealed by intracranial recordings
Murphy, E.; Woolnough, O.; Rollo, P. S.; Roccaforte, Z. J.; Segaert, K.; Hagoort, P.; Tandon, N.
10.1101/2021.04.30.442171 — neuroscience — Posted on 2021-11-08
2780 High Throughput Intact Protein Analysis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry
Pu, F.; Ugrin, S. A.; Radosevich, A. J.; Chang-Yen, D.; Sawicki, J. W.; Talaty, N. N.; Elsen, N. L.; Williams, J. D.
10.1101/2021.11.08.467755 — biochemistry — Posted on 2021-11-08
2783 The bacterial actin-like cell division protein FtsA forms curved antiparallel double filaments upon binding of FtsN
Nierhaus, T.; McLaughlin, S. H.; Bürmann, F.; Kureisaite-Ciziene, D.; Maslen, S.; Skehel, M. J.; Yu, C. W.; Freund, S. M.; Funke, L. F.; Chin, J. W.; Löwe, J.
10.1101/2021.11.08.467742 — microbiology — Posted on 2021-11-08
2785 Fast and sensitive GCaMP calcium indicators for imaging neural populations
Looger, L.; Zhang, Y.; Rozsa, M.; Liang, Y.; Bushey, D.; Wei, Z.; Zheng, J.; Reep, D.; Broussard, G. J.; Tsang, A.; Tsegaye, G.; Narayan, S.; Obara, C. J.; Lim, J.-X.; Patel, R.; Zhang, R.; Ahrens, M. B.; Turner, G. C.; Wang, S. S.; Korff, W.; Schreiter, E. R.; Svoboda, K.; Hasseman, J. P.; Kolb, I.
10.1101/2021.11.08.467793 — neuroscience — Posted on 2021-11-08
2786 Inversely proportional myelin growth due to altered Pmp22 gene dosage identifies PI3K/Akt/mTOR signaling as a novel therapeutic target in HNPP
Krauter, D.; Ewers, D.; Hartmann, T. J.; Volkmann, S.; Kungl, T.; Fledrich, R.; Goebbels, S.; Nave, K.-A.; Sereda, M. W.
10.1101/2021.11.08.467756 — neuroscience — Posted on 2021-11-08
2790 Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells
Veling, M. T.; Nguyen, D. T.; Thadani, N. N.; Oster, M. E.; Rollins, N. J.; Brock, K. P.; Bethel, N. P.; Baker, D.; Way, J. C.; Marks, D. S.; Chang, R. L.; Silver, P. A.
10.1101/2021.10.01.462432 — synthetic biology — Posted on 2021-11-08
2791 New insights into the evolution of glutamine synthetase isoenzymes in plants
Valderrama-Martin, J. M.; Ortigosa, F.; Avila, C.; Canovas, F. M.; Hirel, B.; Canton, F. R.; Canas, R. A.
10.1101/2021.11.08.467771 — plant biology — Posted on 2021-11-08
2793 Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis
Zhu, L.; Tian, C.; Li, L.; Pan, Q.; li, y.; Yang, W.; Fan, L.; Brown, A.; Morrison, M.; Dey, K. M.; Norris, E. J.; Yang, J. J.; Yu, J.; Glazer, E. S.
10.1101/2021.02.19.432035 — cancer biology — Posted on 2021-11-08
2794 Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy.
DeNardo, D. G.; Zuo, C.; Baer, J. M.; Knolhoff, B. L.; Belle, J. I.; Liu, X.; Hogg, G. D.; Fu, C.; Kingston, N. L.; Brenden, M. A.; Alarcon De La Lastra, A.; Dodhiawala, P. B.; Zhou, C.; James, A.; Ding, L.; Kian-Huat, L.; Fields, R. C.; Hawkins, W. G.; Zhao, G.; Weber, J. D.
10.1101/2021.11.08.467770 — cancer biology — Posted on 2021-11-08
2795 Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition
Lin, S.-H.; Lee, Y.-C.; Lin, S.-C.; Yu, G.; Zhu, M.; Song, J. H.; Rivera, K.; Pappin, D. J.; Logothetis, C. J.; Panaretakis, T.; Wang, G.; Yu-Lee, L.-y.
10.1101/2021.11.08.467778 — cancer biology — Posted on 2021-11-08
2796 Transcription modulates chromatin dynamics and locus configuration sampling
Forte, G.; Buckle, A.; Boyle, S.; Marenduzzo, D.; Gilbert, N.; Brackley, C. A.
10.1101/2021.11.08.467739 — biophysics — Posted on 2021-11-08
2801 Improving GWAS discovery and genomic prediction accuracy in Biobank data
Orliac, E. J.; Trejo Banos, D.; Ojavee, S. E.; Läll, K.; Mägi, R.; Visscher, P. M.; Robinson, M. R.
10.1101/2021.08.12.456099 — genomics — Posted on 2021-11-08
2802 INDUCED MUTATIONS IN TaASN-A2 REDUCE FREE ASPARAGINE CONCENTRATION IN THE WHEAT GRAIN
Alarcon Reverte, R.; Xie, Y.; Stromberger, J.; Cotter, J.; Mason, E.; Pearce, S.
10.1101/2021.11.08.467752 — genetics — Posted on 2021-11-08
2803 Prevalent mouse phenotypes in the unexplored druggable genome
Gulyaeva, O.; Hu, Z.; Oprea, T. I.; Lloyd, K.; Gomez, S. M.; Roth, B. L.; McManus, M.
10.1101/2021.11.08.467777 — genetics — Posted on 2021-11-08
2805 Lack of Fe(II) transporters in basal Cyanobacteria complicates iron uptake in ferruginous Archean oceans.
Enzingmueller-Bleyl, T. C.; Boden, J. S.; Herrmann, A. J.; Ebel, K. W.; Sanchez-Baracaldo, P.; Frankenberg-Dinkel, N.; Gehringer, M. M.
10.1101/2021.11.08.467730 — evolutionary biology — Posted on 2021-11-08
2806 Live imaging YAP signaling in mouse embryo development
Gu, B.; Bradshaw, B.; Zhu, M.; Sun, Y.; Hopyan, S.; Rossant, J.
10.1101/2021.08.11.456026 — developmental biology — Posted on 2021-11-08
2808 Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality
Budhraja, A.; Basu, A.; Gheware, A.; Abhilash, D.; Rajagopala, S.; Pakala, S.; Sumit, M.; Ray, A.; Arulselvi, S.; Mathur, P.; Nambirajan, A.; Kumar, S.; Gupa, R.; Wig, N.; Trikha, A.; Guleria, R.; Sarkar, C.; Gupta, I.; Jain, D.
10.1101/2021.11.08.467705 — molecular biology — Posted on 2021-11-08
2810 SARS-COV-2 Delta variant displays moderate resistance to neutralizing antibodies and spike protein properties of higher soluble ACE2 sensitivity, enhanced cleavage and fusogenic activity
Neerukonda, S. N.; Vassell, R.; Lusvarghi, S.; Wang, R.; Echegaray, F.; Bentley, L.; Eakin, A. E.; Erlandson, K. J.; Katzelnick, L. C.; Weiss, C. D.; Wang, W.
10.1101/2021.11.05.467523 — microbiology — Posted on 2021-11-08
2811 Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new tool to study their functional interplay within a single infected CD4+ T cell
Prevost, J.; Richard, J.; Gasser, R.; Medjahed, H.; Kirchhoff, F.; Hahn, B. H.; Kappes, J. C.; Ochsenbauer, C.; Duerr, R.; Finzi, A.
10.1101/2021.11.03.467116 — microbiology — Posted on 2021-11-08
2813 Hypervariable-Locus Melting Typing (HLMT): a novel, fast and inexpensive sequencing-free approach to pathogen typing based on High Resolution Melting (HRM) analysis
Perini, M.; Piazza, A.; Panelli, S.; Papaleo, S.; Alvaro, A.; Vailati, F.; Corbella, M.; Saluzzo, F.; Gona, F.; Castelli, D.; Farina, C.; Marone, P.; Cirillo, D. M.; Cavallero, A.; Zuccotti, G. V.; Comandatore, F.
10.1101/2021.07.01.450706 — microbiology — Posted on 2021-11-08
2814 Host lung environment limits Aspergillus fumigatus germination through a SskA-dependent signaling response
Kirkland, M. E.; Stannard, M.; Kowalski, C. H.; Mould, D. L.; Caffrey-Carr, A. K.; Temple, R. M.; Ross, B. S.; Lofgren, L. A.; Stajich, J. E.; Cramer, R. A.; Obar, J. J.
10.1101/2021.08.27.456493 — microbiology — Posted on 2021-11-08
2815 Long-term Transverse Imaging of the Hippocampus with Glass Microperiscopes
Redman, W. T.; Wolcott, N. S.; Montelisciani, L.; Luna, G.; Marks, T. D.; Sit, K. K.; Yu, C.-H.; Smith, S. L.; Goard, M. J.
10.1101/2021.08.10.455885 — neuroscience — Posted on 2021-11-08
2818 Epidermal Growth Factor Receptor Inhibition Prevents Caveolin-1-dependent Calcifying Extracellular Vesicle Biogenesis
Nik, A. B.; Ng, H. H.; Sun, P.; Iacoviello, F.; Shearing, P. R.; Bertazzo, S.; Mero, D.; Khomtchouk, B. B.; Hutcheson, J. D.
10.1101/2021.11.08.467799 — pathology — Posted on 2021-11-08
2819 Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic Leukemia
Carr, T.; McGregor, S.; Dias, S.; Verykokakis, M.; Le Beau, M. M.; Xue, H.-H.; Bartom, E. T.; Kee, B. L.
10.1101/2021.11.08.467708 — cancer biology — Posted on 2021-11-08
2820 Structural basis of main proteases of coronavirus bound to drug candidate PF-07321332
Li, J.; Lin, C.; Zhou, X.; Zhong, F.; Zeng, P.; Jiang, H.; Yang, Y.; McCormick, P.; Fu, Y.; Zhang, J.
10.1101/2021.11.05.467529 — biophysics — Posted on 2021-11-08
2822 Epidural Electrical Stimulation of the Cervical Dorsal Roots Restores Voluntary Upper Limb Control In Paralyzed Monkeys
Barra, B.; Conti, S.; Perich, M. G.; Zhuang, K.; Schiavone, G.; Fallegger, F.; Galan, K.; James, N.; Barraud, Q.; Delacombaz, M.; Kaeser, M.; Rouiller, E. M.; Milekovic, T.; Lacour, S.; Bloch, J.; Courtine, G.; Capogrosso, M.
10.1101/2020.11.13.379750 — bioengineering — Posted on 2021-11-08
2823 In vitro reconstitution of divisome activation
Radler, P.; Baranova, N.; Caldas, P.; Sommer, C.; Lopez-Pelegrin, M.; Michalik, D.; Loose, M.
10.1101/2021.11.08.467681 — biochemistry — Posted on 2021-11-08
2825 Accelerated decline of genome heterogeneity in the SARS-CoV-2 coronavirus
Oliver, J. L.; Bernaola-Galvan, P.; Perfectti, F.; Gomez-Martin, C.; Verdu, M.; Moya, A.
10.1101/2021.11.06.467547 — genomics — Posted on 2021-11-08
2826 Transcriptome analysis of Plasmodium falciparum isolates from Benin reveals specific gene expression associated with cerebral malaria
Guillochon, E.; Fraering, J.; Joste, V.; Kamaliddin, C.; Vianou, B.; Houzé, L.; Baudrin, L. G.; Faucher, J.-F.; Aubouy, A.; Houzé, S.; Cot, M.; Argy, N.; Taboureau, O.; Bertin, G. I.; NeuroCM group,
10.1101/2021.11.08.467248 — genomics — Posted on 2021-11-08
2827 The molecular evolution of spermatogenesis across mammals
Murat, F.; Mbengue, N.; Winge, S. B.; Trefzer, T.; Leushkin, E.; Sepp, M.; Cardoso-Moreira, M.; Schmidt, J.; Schneider, C.; Mössinger, K.; Brüning, T.; Lamanna, F.; Belles, M. R.; Conrad, C.; Kondova, I.; Bontrop, R.; Behr, R.; Khaitovich, P.; Pääbo, S.; Marques-Bonet, T.; Grützner, F.; Almstrup, K.; Schierup, M. H.; Kaessmann, H.
10.1101/2021.11.08.467712 — evolutionary biology — Posted on 2021-11-08
2831 Brain Networks Detectable by fMRI during On-Line Self Report of Hallucinations in Schizophrenia
Gill, K. S.; Percival, C.; Roes, M.; Arreaza, L.; Chinchani, A.; Sanford, N.; Sena, W.; Mohammadsadeghi, H.; Menon, M.; Hughes, M.; Carruthers, S.; Sumner, P.; Woods, W.; Jardri, R.; Sommer, I. E.; Rossell, S. L.; Woodward, T. S.
10.1101/2021.11.06.467564 — neuroscience — Posted on 2021-11-08
2832 The learning curve of murine subretinal injection among clinically trained ophthalmic surgeons
Huang, P.; Narendran, S.; Pereira, F.; Fukuda, S.; Nagasaka, Y.; Apicella, I.; Yerramothu, P.; Marion, K. M.; Cai, X.; Sadda, S. R.; Gelfand, B. D.; Ambati, J.
10.1101/2021.11.05.467533 — neuroscience — Posted on 2021-11-08
2833 Oscillations support short latency co-firing of neurons during human episodic memory formation.
Roux, F.; Parish, G. M.; Chelvarajah, R.; Rollings, D. T.; Sawlani, V.; Hamer, H.; Gollwitzer, S.; Kreiselmeyer, G.; ter Wal, M. J.; Kolibius, L.; Staresina, B.; Wimber, M.; Self, M. W.; Hanslmayr, S.
10.1101/2021.01.28.428480 — neuroscience — Posted on 2021-11-08
2835 The Immune Signatures Data Resource: A compendium of systems vaccinology datasets
Diray-Arce, J.; Miller, H. E. R.; Henrich, E.; Gerritsen, B.; Mule, M. P.; Fourati, S.; Gygi, J.; Hagan, T.; Tomalin, L.; Rychov, D.; Kazmin, D.; Chawla, D. G.; Meng, H.; Dunn, P.; Campbell, J.; The Human Immunology Project Consortium (HIPC), ; Sarwal, M.; Tsang, J.; Levy, O.; Pulendran, B.; Sekaly, R.-P.; Floratos, A.; Gottardo, R.; Kleinstein, S.; Suarez-Farinas, M.
10.1101/2021.11.05.465336 — systems biology — Posted on 2021-11-08
2837 Lipid Alterations in African American Prostate Cancer
Ravindran, A.; Piyarathna, D. W. B.; Gohlke, J.; Putluri, V.; Soni, T.; Lloyd, S.; Castro, P.; Pennathur, S.; Jones, J. A.; Ittmann, M.; Putluri, N.; Michailidis, G.; Rajendiran, T.; Sreekumar, A.
10.1101/2021.11.05.467481 — cancer biology — Posted on 2021-11-08
2838 A connectivity signature for glioblastoma
Hai, L.; Hoffmann, D. C.; Mandelbaum, H.; Xie, R.; Ito, J.; Jung, E.; Weil, S.; Sievers, P.; Venkataramani, V.; Azorin, D. D.; Ernst, K.; Reibold, D.; Will, R.; Suva, M. L.; Herold-Mende, C.; Sahm, F.; Winkler, F.; Schlesner, M.; Wick, W.; Kessler, T.
10.1101/2021.11.07.465791 — cancer biology — Posted on 2021-11-08
2840 Genetic continuity of Indo-Iranian speakers since the Iron Age in southern Central Asia.
Guarino-Vignon, P. C. P.; Marchi, N.; Bendezu-Sarmiento, J.; Heyer, E.; Bon, C.
10.1101/2021.11.04.466891 — genomics — Posted on 2021-11-08
2841 Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates
Kasiewicz, L. N.; Biswas, S.; Beach, A.; Ren, H.; Dutta, C.; Mazzola, A. M.; Rohde, E.; Chadwick, A.; Cheng, C.; Musunuru, K.; Kathiresan, S.; Malyala, P.; Rajeev, K. G.; Bellinger, A. M.
10.1101/2021.11.08.467731 — genetics — Posted on 2021-11-08
2843 Human centromere formation activates transcription and opens chromatin fibre structure
Naughton, C.; Huidobro, C.; Catacchio, C. R.; Buckle, A.; Grimes, G. R.; Nozawa, R.-S.; Purgato, S.; Rocchi, M.; Gilbert, N.
10.1101/2021.08.01.454615 — molecular biology — Posted on 2021-11-08
2846 Recurrent urinary tract infection and estrogen shape the taxonomic ecology and functional potential of the postmenopausal urobiome
Neugent, M. L.; Kumar, A.; Hulyalkar, N. V.; Lutz, K. C.; Nguyen, V. H.; Fuentes, J. L.; Zhang, C.; Nguyen, A.; Sharon, B. M.; Kuprasertkul, A.; Arute, A. P.; Li, Q.; Xing, C.; Shulaev, V.; Zimmern, P. E.; Palmer, K. L.; De Nisco, N. J.
10.1101/2021.11.06.467345 — microbiology — Posted on 2021-11-08
2847 A comparative analysis of memory B cell and antibody responses against Plasmodium falciparum merozoite surface protein 1 in children and adults from Uganda
Gonzales, S. J.; Clarke, K. N.; Batugedara, G.; Braddom, A. E.; Garza, R.; Reyes, R. A.; Ssewanyana, I.; Garrison, K. C.; Ippolito, G. C.; Greenhouse, B. M.; Bol, S.; Bunnik, E. M.
10.1101/2021.11.04.467302 — immunology — Posted on 2021-11-08
2848 ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples
Kissel, T.; Hafkenscheid, L.; van Wesemael, T. J.; Tamai, M.; Kawashiri, S.-y.; Kawakami, A.; El-Gabalawy, H.; van Schaardenburg, D.; Rantapaa Dahlqvist, S.; Wuhrer, M.; van der Helm-van Mil, A. H. M.; Allaart, R.; van der Woude, D.; Scherer, H. U.; Toes, R. E. M.; Huizinga, T. W. J.
10.1101/2021.11.05.467407 — immunology — Posted on 2021-11-08
2850 Sexual dimorphic responses of C57BL/6 mice to Fisetin or Dasatinib and Quercetin cocktail oral treatment
Fang, Y.; Medina, D.; Stockwell, R.; McFadden, S.; Quinn, K.; Peck, M. R.; Bartke, A.; Hascup, K. N.; Hascup, E. R.
10.1101/2021.11.08.467509 — physiology — Posted on 2021-11-08
2852 The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics
Ramos-Mucci, L.; Elsheikh, A.; Keenan, C.; Eliasy, A.; D'Aout, K.; Bou-Gharios, G.; Comerford, E.; Poulet, B.
10.1101/2021.11.08.467455 — pathology — Posted on 2021-11-08
2854 Identification of known and novel long non-coding RNAs potentially responsible for the effects of BMD GWAS loci
Abood, A.; Mesner, L.; Rosenow, W.; Al-Barghouthi, B. M.; Horwitz, N.; Morgan, E. F.; Gerstenfeld, L. C.; Farber, C. R.
10.1101/2021.11.04.467171 — genomics — Posted on 2021-11-08
2855 Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan
Brouwer, R. M.; Klein, M.; Grasby, K. L.; Schnack, H. G.; Jahanshad, N.; Teeuw, J.; Thomopoulos, S. I.; Sprooten, E.; Franz, C. E.; Gogtay, N.; Kremen, W.; Panizzon, M. S.; Olde Loohuis, L. M.; Whelan, C. D.; Aghajani, M.; Alloza, C.; Alnaes, D.; Artiges, E.; Ayesa-Arriola, R.; Barker, G. J.; Bastin, M. E.; Blok, E.; Boen, E.; Breukelaar, I. A.; Bright, J. K.; Buimer, E. E.; Bülow, R.; Cannon, D. M.; Ciufolini, S.; Crossley, N. A.; Damatac, C. G.; Dazzan, P.; de Mol, C. L.; de Zwarte, S. M.; Desrivieres, S.; Diaz-Caneja, C. M.; Doan, N. T.; Dohm, K.; Fröhner, J. H.; Goltermann, J.; Grigis, A
10.1101/2020.04.24.031138 — genetics — Posted on 2021-11-08
2858 Multiple brace root phenotypes promote anchorage and limit root lodging in maize
Hostetler, A. N.; Erndwein, L.; Reneau, J. W.; Stager, A.; Tanner, H. G.; Cook, D.; Sparks, E. E.
10.1101/2021.05.12.443923 — plant biology — Posted on 2021-11-08
2859 TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Demirdizen, E.; Al-Ali, R.; Narayanan, A.; Sun, X.; Varga, J. P.; Steffl, B.; Brom, M.; Krunic, D.; Schmidt, C.; Schmidt, G.; Bestvater, F.; Taranda, J.; Turcan, S.
10.1101/2021.11.05.467405 — cancer biology — Posted on 2021-11-08
2861 Aggregation Tool for Genomic Concepts (ATGC): A deep learning framework for sparse genomic measures
Anaya, J.; Sidhom, J.-W.; Cummings, C. A.; Baras, A. S.; The AACR Project GENIE Consortium,
10.1101/2020.08.05.237206 — bioinformatics — Posted on 2021-11-08
2863 From group to individual - Genotyping by pool sequencing eusocial colonies
Eynard, S. E.; Vignal, A.; Basso, B.; Le Conte, Y.; Decourtye, A.; Genestout, L.; Labarthe, E.; Mondet, F.; Tabet, K.; Servin, B.
10.1101/2021.11.08.467442 — genomics — Posted on 2021-11-08
2865 ATM-dependent formation of a novel chromatin compartment regulates the Response to DNA Double Strand Breaks and the biogenesis of translocations
Arnould, C.; Rocher, V.; Bader, A. S.; Lesage, E.; Puget, N.; Clouaire, T.; Mourad, R.; Noordermeer, D.; Bushell, M.; Legube, G.
10.1101/2021.11.07.467654 — molecular biology — Posted on 2021-11-08
2867 Modelling novelty detection in the thalamocortical loop
Han, C.; English, G.; Saal, H. P.; Indiveri, G.; Gilra, A.; von der Behrens, W.; Vasilaki, E.
10.1101/2021.11.08.467674 — neuroscience — Posted on 2021-11-08
2870 Dosage of duplicated and antifunctionalized homeobox proteins influences spikelet development in barley
Thirulogachandar, V.; Govind, G.; Hensel, G.; Kale, S.; Kuhlmann, M.; Eschen-Lippold, L.; Rutten, T.; Koppolu, R.; Rajaraman, J.; Reddy, P. S.; Seiler, C.; Sakuma, S.; Jayakodi, M.; Lee, J.; Kumlehn, J.; Komatsuda, T.; Schnurbusch, T.; Sreenivasulu, N.
10.1101/2021.11.08.467769 — plant biology — Posted on 2021-11-08
2871 Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions
Wenta, T.; Schmidt, A.; Zhang, Q.; Devarajan, R.; Singh, P.; Yang, X.; Ahtikoski, A.; Vaarala, M. H.; Wei, G.-H.; Manninen, A.
10.1101/2021.11.08.467671 — cancer biology — Posted on 2021-11-08
2874 Electrical signature of heterogeneous human mesenchymal stem cells
Tsau, T.; Vyas, P.; Crowell, L.; Tran, M.; Ward, D.; Qin, Y.; Castro, A.; Adams, T.
10.1101/2021.11.08.467665 — bioengineering — Posted on 2021-11-08
2878 Cocaine-induced locomotor activation differs across six sets of inbred mouse substrains
Gaines, C. H.; Schoenrock, S. A.; Farrington, J.; Lee, D. F.; Aponte-Collazo, L. J.; Shaw, G.; Miller, D. R.; Ferris, M. T.; Pardo-Manuel de Villena, F.; Tarantino, L. M.
10.1101/2021.11.08.467748 — genetics — Posted on 2021-11-08
2879 Ancient mitogenomes unravel massive genetic diversity loss during near extinction of Alpine ibex
Robin, M.; Ferrari, G. J.; Akguel, G.; Von Seth, J.; Schuenemann, V. J.; Dalen, L.; Grossen, C.
10.1101/2021.11.07.467348 — evolutionary biology — Posted on 2021-11-08
2881 Whole-genomes from the extinct Xerces Blue butterfly reveal low diversity and long-term population decline
de-Dios, T.; Fontsere, C.; Renom, P.; Stiller, J.; Llovera, L.; Uliano-Silva, M.; Wright, C.; Lizano, E.; Navarro, A.; Robbins, R. K.; Blaxter, M.; Marques-Bonet, T.; Vila, R.; Lalueza-Fox, C.
10.1101/2021.11.08.467457 — evolutionary biology — Posted on 2021-11-08
2883 Low-coverage reduced representation sequencing reveals subtle within-island genetic structure in Aldabra giant tortoises
Cilingir, F. G.; Hansen, D.; Bunbury, N.; Postma, E.; Baxter, R.; Turnbull, L. A.; Ozgul, A.; Grossen, C.
10.1101/2021.11.08.467072 — ecology — Posted on 2021-11-08
2884 Visceral organ morphogenesis via calcium-patterned muscle contractions
Mitchell, N. P.; Cislo, D.; Shankar, S.; Lin, y.; Shraiman, B. I.; Streichan, S. J.
10.1101/2021.11.07.467658 — developmental biology — Posted on 2021-11-08
2885 Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance
Thamkachy, R.; Medina-Pritchard, B.; Park, S. H.; Chiodi, C. G.; Zou, J.; de la Torre-Barranco, M.; Shimanaka, K.; Abad, M. A.; Gallego Paramo, C.; Feederle, R.; Ruksenaite, E.; Heun, P.; Davies, O. R.; Rappsilber, J.; Schneidman-Duhovny, D.; Cho, U.-S.; Jeyaprakash, A. A.
10.1101/2021.11.08.466737 — cell biology — Posted on 2021-11-08
2886 ETV2 regulates PARP-1 binding protein to induce ER stress-mediated cell death in tuberin-deficient cells
Shrestha, S.; Lamattina, A.; Pacheco-Rodriguez, G.; Ng, J.; Liu, X.; Sonawane, A.; Imani, J.; Kosmas, K.; Louis, P.; Hentschel, A.; Christou, H. A.; Henski, E. P.; Glass, K.; Perrella, M. A.; Moss, J.; Tantisira, K.; El-Chemaly, S.
10.1101/2021.11.08.467714 — cell biology — Posted on 2021-11-08
2889 Heteromerization of alkaline-sensitive two-pore domain potassium channels
Khoubza, L.; Kim, E.-J.; Chatelain, F. C.; Feliciangeli, S.; Kang, D.; Lesage, F.; Bichet, D.
10.1101/2021.11.08.467666 — molecular biology — Posted on 2021-11-08
2890 A mixed blessing of viruses in wastewater treatment plants
Shi, L.-D.; Dong, X.; Liu, Z.; Yang, Y.; Lin, J.-G.; Li, M.; Gu, J.-D.; Zhu, L.-Z.; Zhao, H.-P.
10.1101/2021.11.08.467685 — microbiology — Posted on 2021-11-08
2891 Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease
Keshvari, S.; Genz, B.; Teakle, N.; Caruso, M.; Cestari, M. F.; Patkar, O. L.; Tse, B. W.; Sokolowski, K. A.; Ebersbach, H.; Jascur, J.; MacDonald, K. P.; Miller, G.; Ramm, G. A.; Pettit, A. R.; Clouston, A. D.; Powell, E. E.; Hume, D. A.; Irvine, K. M.
10.1101/2021.11.07.467663 — immunology — Posted on 2021-11-08
2892 Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment
Handel, A. E.; Cheuk, S.; Dhalla, F.; Maio, S.; Hubscher, T.; Rota, I.; Deadman, M. E.; Ekwall, O.; Lutolf, M.; Weinberg, K.; Hollander, G.
10.1101/2021.11.08.467624 — immunology — Posted on 2021-11-08
2893 Interneuron Control of C. elegans Developmental Decision-making
Chai, C. M.; Torkashvand, M.; Seyedolmohadesin, M.; Park, H.; Venkatachalam, V.; Sternberg, P. W.
10.1101/2021.11.07.467589 — neuroscience — Posted on 2021-11-08
2899 The Recombination Landscape of the Khoe-San - the Upper Limits of Recombination Divergence in Humans
van Eeden, G.; Uren, C.; Pless, E.; Mastoras, M.; van der Spuy, G.; Tromp, G.; Henn, B.; Möller, M.
10.1101/2021.11.07.467603 — bioinformatics — Posted on 2021-11-08
2900 Differential richness inference for 16S rRNA marker gene surveys
Kumar, M. S.; Slud, E. V.; Hehnly, C.; Zhang, L.; Broach, J.; Irizarry, R. A.; Schiff, S. J.; Paulson, J. N.
10.1101/2021.11.07.467583 — bioinformatics — Posted on 2021-11-08
2909 Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome
Asada Kitamura, R.; Maxwell, K.; Ye, W.; Kries, K.; Brown, C.; Augsornworawat, P.; Hirsch, Y.; Johansson, M.; Weiden, T.; Ekstein, J.; Cohen, J.; Klee, J.; Leslie, K.; Simeonov, A.; Henderson, M.; Millman, J. R.; Urano, F.
10.1101/2021.11.07.467657 — genetics — Posted on 2021-11-08
2912 Telomere length regulation by Rif1 protein from Hansenula polymorpha
Malyavko, A. N.; Petrova, O. A.; Zvereva, M. I.; Polshakov, V.; Dontsova, O. A.
10.1101/2021.11.07.467630 — molecular biology — Posted on 2021-11-08
2915 Beyond Fixation: detailed characterization of neural selectivity in free-viewing primates
Yates, J. L.; Coop, S. H.; Sarch, G. H.; Wu, R.-J.; Butts, D. A.; Rucci, M.; Mitchell, J. F.
10.1101/2021.11.06.467566 — neuroscience — Posted on 2021-11-08
2916 Sonogenetic stimulation of the brain at a spatiotemporal resolution suitable for vision restoration
Cadoni, S.; Demene, C.; Provansal, M.; Nguyen, D.; Nelidova, D.; Labernede, G.; Alcala, I.; Lubetzki, J.; Goulet, R.; Burban, E.; Degardin, J.; Simonutti, M.; Gauvain, G.; Arcizet, F.; Marre, O.; Dalkara, D.; Roska, B.; Sahel, J. A.; Tanter, M.; Picaud, S.
10.1101/2021.11.07.467597 — neuroscience — Posted on 2021-11-08
2917 Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice
Xian, Q.; Qiu, Z.; Kala, S.; Wong, K. F.; Murugappan, S.; Wu, Y.; Hou, X.; Zhu, J.; Guo, J.; SUN, L.
10.1101/2021.11.06.467579 — neuroscience — Posted on 2021-11-08
2918 Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy
Zhang, Y.; Li, M.; Yu, B.; Lu, S.; Zhang, L.; Zhu, S.; Yu, Z.; Xia, T.; Huang, H.; Jiang, W.; Zhang, S.; Sun, L.; Ye, Q.; Sun, J.; Zhu, H.; Huang, P.; Hong, H.; Yu, S.; Li, W.; Ai, D.; Fan, J.; Li, W.; Song, H.; Xu, L.; Chen, X.; Ou, J.; Yang, J.; Li, W.; Hu, Y.; Wu, W.
10.1101/2021.11.07.467626 — neuroscience — Posted on 2021-11-08
2919 Robust transcriptional profiling and identification of differentially expressed genes with low input RNA sequencing of adult hippocampal neural stem and progenitor populations
Denninger, J. K.; Walker, L. A.; Chen, X.; Turkoglu, A. M.; Pan, A.; Tapp, Z.; Senthilvelan, S.; Rindani, R.; Kokiko-Cochran, O.; Bundschuh, R.; Yan, P.; Kirby, E. D.
10.1101/2021.11.07.467608 — neuroscience — Posted on 2021-11-08
2925 Making Common Fund data more Findable: Catalyzing a Data Ecosystem
Charbonneau, A. L.; Brady, A.; Brown, C. T.; Sansone, S.-A.; Ma'ayan, A.; Wagner, R.; Carter, R.; Harris, R. M.; Gingrich, A.; Lim, M. C. W.; Munro, J. B.; Clarke, D. J. B.; Creasy, H. H.; Rocca-Serra, P.; Jeon, M.; Liming, R. L.; Schuler, R. E.; Romano, C.; Chard, K.; Giglio, M.; Nadendla, S.; Hodges, T. K.; Mandal, M.; Canchi, S.; Waldrop, A.; White, O.
10.1101/2021.11.05.467504 — bioinformatics — Posted on 2021-11-08
2927 RUV-III-NB: Normalization of single cell RNA-seq Data
Salim, A.; Molania, R.; Wang, J.; De Livera, A.; Thijssen, R.; Speed, T. P.
10.1101/2021.11.06.467575 — bioinformatics — Posted on 2021-11-08
2928 A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies
Li, Z.; Li, X.; Zhou, H.; Gaynor, S. M.; Selvaraj, M. S.; Arapoglou, T.; Quick, C.; Liu, Y.; Chen, H.; Sun, R.; Dey, R.; Arnett, D. K.; Bielak, L. F.; Bis, J. C.; Blackwell, T.; Blangero, J.; Boerwinkle, E.; Bowden, D. W.; Brody, J. A.; Cade, B. E.; Conomos, M.; Correa, A.; Cupples, L. A.; Curran, J. E.; de Vries, P. S.; Duggirala, R.; Freedman, B. I.; Goring, H. H. H.; Guo, X.; Kalyani, R. R.; Kooperberg, C.; Kral, B. G.; Lange, L. A.; Manichaikul, A. W.; Martin, L. W.; Mitchell, B. D.; Montasser, M.; Morrison, A.; Naseri, T.; O'Connell, J. R.; Palmer, N. D.; Peyser, P. A.; Psaty, B. M.; Raff
10.1101/2021.11.05.467531 — genetics — Posted on 2021-11-08
2931 Biogeographic multi-species occupancy models for large-scale survey data
Socolar, J. B.; Mills, S. C.; Haugaasen, T.; Gilroy, J. J.; Edwards, D. P.
10.1101/2021.11.05.467527 — ecology — Posted on 2021-11-08
2933 Developmental regulation and functional prediction of microRNAs in an expanded Fasciola hepatica miRNome
Herron, C. M.; O'Connor, A.; Robb, E.; McCammick, E.; Hill, C.; Marks, N. J.; Robinson, M. W.; Maule, A.; McVeigh, P.
10.1101/2021.11.08.467689 — molecular biology — Posted on 2021-11-08
2941 AN ECONOMIC, SQUARE-SHAPED FLAT-FIELD ILLUMINATION MODULE FOR TIRF-BASED SUPER-RESOLUTION MICROSCOPY
Lam, J. Y. L.; Wu, Y.; Dimou, E.; Zhang, Z.; Cheetham, M. R.; Koerbel, M.; Xia, Z.; Klenerman, D.; Danial, J. S. H.
10.1101/2021.11.05.467489 — biophysics — Posted on 2021-11-08
2948 The Ecology of Palm Genomes: Repeat-associated genome size expansion is constrained by aridity
Schley, R. J.; Pellicer, J.; Ge, X.-J.; Barrett, C. F.; Bellot, S.; Guignard, M.; Novak, P.; Suda, J.; Fraser, D.; Baker, W. J.; Dodsworth, S.; Macas, J. J.; Leitch, A.; Leitch, I. J.
10.1101/2021.11.04.467295 — evolutionary biology — Posted on 2021-11-08
2950 MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1
La Spada, A.; Branch, M. R.; Hsu, C.; Ohnishi, K.; Lee, E.; Meisenhelder, J.; Winborn, B. J.; Sopher, B.; Taylor, J. P.; Hunter, T.
10.1101/2021.11.08.467702 — cell biology — Posted on 2021-11-08
2953 Reward timing matters in motor learning
Vassiliadis, P.; Lete, A.; Duque, J.; Derosiere, G.
10.1101/2021.10.15.464563 — neuroscience — Posted on 2021-11-08
2960 Age-Related Differences in Ventral Striatal and Default Mode Network Function During Reciprocated Trust
Fareri, D. S.; Hackett, K.; Tepfer, L. J.; Kelly, V. A.; Henninger, N.; Reeck, C.; Giovannetti, T.; Smith, D. V.
10.1101/2021.07.29.454071 — neuroscience — Posted on 2021-11-08
2961 Effects on brain activity after creative mathematical reasoning when considering individual differences in cognitive ability
Karlsson Wirebring, L.; Wiklund-Hornqvist, C.; Stillesjo, S.; Granberg, C.; Lithner, J.; Andersson, M.; Nyberg, L.; Jonsson, B.
10.1101/2021.03.30.437492 — neuroscience — Posted on 2021-11-08
2962 Fungal biodiversity in Arctic paleoecosystems assessed by metabarcoding of lake sedimentary ancient DNA
Seeber, P. A.; von Hippel, B.; Kauserud, H.; Loeber, U.; Stoof-Leichsenring, K.; Herzschuh, U.; Epp, L.
10.1101/2021.11.02.462738 — ecology — Posted on 2021-11-08
2963 Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development
Phansalkar, R. S.; Krieger, J.; Zhao, M.; Kolluru, S. S.; Jones, R. C.; Quake, S. R.; Weissman, I. L.; Bernstein, D.; Winn, V. D.; D'Amato, G.; Red-Horse, K.
10.1101/2021.04.25.441380 — developmental biology — Posted on 2021-11-08
2964 Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens
Numberger, D.; Zoccarato, L.; Woodhouse, J.; Ganzert, L.; Sauer, S.; Grossart, H.-P.; Greenwood, A. D.
10.1101/2020.06.26.173328 — microbiology — Posted on 2021-11-08
2965 Mushroom body input connections form independently of sensory activity in Drosophila melanogaster
Hayashi, T.; MacKenzie, A. J.; Ganguly, I.; Smihula, H.; Jacob, M. S.; Litwin-Kumar, A.; Caron, S. J. C.
10.1101/2021.11.06.467552 — neuroscience — Posted on 2021-11-07
2966 A Practical Guide to Sparse k-means Clustering for Studying Molecular Development of the Human Brain
Balsor, J. L.; Arbabi, K.; Singh, D.; Kwan, R.; Zaslavsky, J.; Jeyanesan, E.; Murphy, K. M.
10.1101/2020.12.31.425014 — neuroscience — Posted on 2021-11-08
2970 An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement
Tian, G.; Hui, M.; Macchia, D.; Derdeyn, P.; Rogers, A.; Hubbard, E.; Liu, C.; Bartas, K.; Carroll, S.; Beier, K.
10.1101/2021.11.05.467532 — neuroscience — Posted on 2021-11-07
2975 Modelling the coupling of the M-clock and C-clock in lymphatic muscle cells
Hancock, E. J.; Zawieja, S. D.; Macaskill, C.; Davis, M. J.; Bertram, C. D.
10.1101/2021.11.07.467629 — biophysics — Posted on 2021-11-07
2977 Identification of Low Population States in Cryo-EM Using Deep Learning
Fraser, A.; Prokhorov, N. S.; Miller, J. M.; Knyazhanskaya, E. S.; Leiman, P. G.
10.1101/2021.11.06.467553 — biophysics — Posted on 2021-11-07
2978 Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome
Kawakami, K.; Hamaguchi, T.; Hirose, Y.; Kosumi, D.; Miyata, M.; Kamiya, N.; Yonekura, K.
10.1101/2021.11.07.467602 — biochemistry — Posted on 2021-11-07
2980 Tumour mutations in long noncoding RNAs that enhance cell fitness
Esposito, R.; Lanzos, A.; Polidori, T.; Guillen-Ramirez, H.; Merlin, B.; Mela, L.; Zoni, E.; Buechi, I.; Hovhannisyan, L.; McCluggage, F.; Medo, M.; Basile, G.; Meise, D. F.; Ramnarayanan, S.; Zwyssig, S.; Wenger, C.; Schwarz, K.; Vancura, A.; Bosch-Guiteras, N.; JuliKruithof-deo, M.; Zimmer, Y.; Medova, M.; Stroka, D.; Fox, A.; Johnson, R.
10.1101/2021.11.06.467555 — genomics — Posted on 2021-11-07
2983 Opposing roles of Granzymes A and B in the immune response to intestinal infection
Vandereyken, M.; Chawla, A. S.; Arias, M.; Santiago, L.; Wenner, N.; Thomson, S.; Dikovskaya, D.; Nguyen, C.; Hinton, J. C. D.; Pardo, J.; Swamy, M.
10.1101/2021.11.07.467595 — immunology — Posted on 2021-11-07
2985 Bacteria modulate tamoxifen-induced death via host fatty acid metabolism
Diot, C.; Garcia-Gonzalez, A. P.; Vieira, A. F.; Walker, M.; Honeywell, M.; Doyle, H.; Rivera, Y.; Na, H.; Zhang, H.; Lee, M.; Olsen, C. P.; Walhout, A. J. M.
10.1101/2021.11.05.467497 — systems biology — Posted on 2021-11-07
2986 Galectin-9 signaling drives breast cancer invasion through matrix
Pally, D.; Banerjee, M.; Hussain, S.; Kumar, R. V.; Petersson, A.; Rosendal, E.; Gunnarsson, L.; Peterson, K.; Leffler, H.; Nilsson, U. J.; Bhat, R.
10.1101/2021.11.06.467574 — cancer biology — Posted on 2021-11-07
2987 Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia
Payne, M.; Tsaponina, O.; Caalim, G.; Greenfield, H.; Milton-Harris, L.; Mancini, E. J.; Blair, A.; Heesom, K. J.; Tonks, A.; Darley, R. L.; Roberts, S. G.; Morgan, R. G.
10.1101/2021.11.06.467095 — cancer biology — Posted on 2021-11-07
2989 Cell cycle stage classification using phase imaging with computational specificity
He, Y.; He, S.; Kandel, M. E.; Lee, Y. J.; Hu, C.; Sobh, N.; Anastasio, M.; Popescu, G.
10.1101/2021.11.05.467526 — bioengineering — Posted on 2021-11-07
2990 Mesowestern Blot: Simultaneous Analysis of Hundreds of Sub-Microliter Lysates
Zadeh, C. O.; Huggins, J. R.; Westbury, B. C.; Interiano, W. R.; Phillips, S. A.; Erdem, C.; Sarmah, D.; Dodd, W. B.; Meredith, W. O.; Birtwistle, M. R.
10.1101/2021.11.07.467614 — biochemistry — Posted on 2021-11-07
2992 Active DNA demethylation of developmental cis-regulatory regions predates vertebrate origins
Skvortsova, K.; Bertrand, S.; Voronov, D.; Duckett, P. E.; Ross, S. E.; Magri, M. S.; Maeso, I.; Weatheritt, R. J.; Gomez-Skarmeta, J. L.; Arnone, M. I.; Escriva, H.; Bogdanovic, O.
10.1101/2021.11.07.467601 — genomics — Posted on 2021-11-07
2993 Molecular recording of sequential cellular events into DNA
Loveless, T. B.; Carlson, C. K.; Hu, V. J.; Dentzel Helmy, C. A.; Liang, G.; Ficht, M.; Singhai, A.; Liu, C. C.
10.1101/2021.11.05.467507 — genetics — Posted on 2021-11-07
2994 Integrated analyses of the single-cell ATAC-seq and RNA-seq reveal the epigenetic landscape of human ovarian aging
Xu, Y.; Chen, J.; Gu, S.; Liu, Y.; Ni, H.; Huang, Y.; Gao, S.; Sheng, N.; Zhang, X.; He, X.; Zhou, S.; Ge, W.
10.1101/2021.11.07.467593 — genetics — Posted on 2021-11-07
2996 Lipopolysaccharide induces placental mitochondrial dysfunction by reducing MNRR1 levels via a TLR4-independent pathway
Purandare, N.; Kunji, Y.; Xi, Y.; Romero, R.; Gomez-Lopez, N.; Fribley, A.; Grossman, L. I.; Aras, S.
10.1101/2021.11.06.467519 — molecular biology — Posted on 2021-11-07
2999 Maternal effects on early-life gut microbiome maturation in a wild nonhuman primate
Baniel, A.; Petrullo, L.; Mercer, A.; Reitsema, L.; Sams, S.; Beehner, J. C.; Bergman, T. J.; Snyder-Mackler, N.; Lu, A.
10.1101/2021.11.06.467515 — microbiology — Posted on 2021-11-07
3002 Gabra5LHA Mediate Astrocytic GABA-induced Obesity via Decreasing Energy Expenditure
Lee, C. J.; Sa, M.; Yoo, E.-S.; Koh, W.; Park, M. G.; Jang, H.-J.; Yang, Y. R.; Lim, J.; Won, W.; Kwon, J.; Bhalla, M.; An, H.; Seong, Y.; Park, K. D.; Suh, P.-G.; Sohn, J.-W.
10.1101/2021.11.07.467613 — neuroscience — Posted on 2021-11-07
3003 Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons
Printz, Y.; Patil, P.; Mahn, M.; Benjamin, A.; Litvin, A.; Levy, R.; Bringmann, M.; Yizhar, O.
10.1101/2021.11.07.467611 — neuroscience — Posted on 2021-11-07
3009 Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation
Lyons, S. P.; Greiner, E. C.; Cressey, L. E.; Adamo, M. E.; Kettenbach, A. N.
10.1101/2021.11.07.467570 — biochemistry — Posted on 2021-11-07
3011 Next-generation phylogeography resolves post-glacial colonization patterns in a widespread carnivore, the red fox (Vulpes vulpes), in Europe.
McDevitt, A. D.; Coscia, I.; Browett, S. S.; Ruiz-Gonzalez, A.; Statham, M. J.; Ruczynska, I.; Roberts, L.; Stojak, J.; Frantz, A. C.; Noren, K.; Agren, E.; Learmount, J.; Basto, M.; Fernandes, C.; Stuart, P.; Tosh, D. G.; Sindicic, M.; Andreanszky, T.; Isomursu, M.; Panek, M.; Korolev, A.; Okhlopkov, I. M.; Saveljev, A. P.; Pokorny, B.; Flajsman, K.; Harrison, S. W.; Lobkov, V.; Cirovic, D.; Mullins, J.; Pertoldi, C.; Randi, E.; Sacks, B. N.; Kowalczyk, R.; Wojcik, J. M.
10.1101/2020.02.21.954966 — evolutionary biology — Posted on 2021-11-07
3015 VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.
Temerozo, J. R.; Sacramento, C. Q.; Fintelman-Rodrigues, N.; Pao, C. R. R.; de Freitas, C. S.; Dias, S. d. S. G.; Ferreira, A. C.; Mattos, M.; Soares, V. C.; Teixeira, L.; de Azevedo-Quintanilha, I. G.; Hottz, E. D.; Kurtz, P.; Bozza, F. A.; Bozza, P. T.; Souza, T. M. L.; Bou-Habib, D. C.
10.1101/2020.07.25.220806 — immunology — Posted on 2021-11-07
3016 The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)
Ebrahim, A.; Riley, B. T.; Kumaran, D.; Andi, B.; Fuchs, M. R.; McSweeney, S.; Keedy, D. A.
10.1101/2021.05.03.437411 — biophysics — Posted on 2021-11-07
3017 SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion
Essalmani, R.; Jain, J.; Susan-Resiga, D.; Andreo, U.; Evagelidis, A.; Derbali, R. M.; Huynh, D.; Dallaire, F.; Laporte, M.; Delpal, A.; Sutto-Ortiz, P.; Coutard, B.; Mapa, C.; Wilcoxen, K.; Decroly, E.; Pham, T.; Cohen, E. A.; Seidah, N. G.
10.1101/2020.12.18.423106 — biochemistry — Posted on 2021-11-07
3018 Evaluation of SARS-CoV-2 Entry, Inflammation and New Therapeutics in Human Lung Tissue Cells
Grau-Exposito, J.; Perea, D.; Suppi, M.; Massana, N.; Vergara, A.; Soler, M. J.; Blanco, J.; Trinite, B.; Garcia-Perez, J.; Alcami, J.; Serrano-Mollar, A.; Rosado, J.; Falco, V.; Genesca, M.; Buzon, M. J.
10.1101/2021.04.21.440731 — microbiology — Posted on 2021-11-07
3019 Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection
Moses, M. E.; Hofmeyr, S.; Cannon, J. L.; Andrews, A.; Gridley, R.; Hinga, M.; Leyba, K.; Pribisova, A.; Surjadidjaja, V.; Tasnim, H.; Forrest, S.
10.1101/2021.05.19.444569 — immunology — Posted on 2021-11-07
3020 EEG-based visual deviance detection in freely behaving mice
Kat, R.; van den Berg, B.; Perenboom, M. J. L.; Schenke, M.; van den Maagdenberg, A. M. J. M.; Bruining, H.; Tolner, E. A.; Kas, M. J. H.
10.1101/2021.06.14.448331 — neuroscience — Posted on 2021-11-07
3023 Increasing cell size remodels the proteome and promotes senescence
Lanz, M. C.; Zatulovskiy, E.; Swaffer, M. P.; Zhang, L.; Ilerten, I.; Zhang, S.; You, D. S.; Marinov, G. K.; McAlpine, P.; Elias, J. E.; Skotheim, J. M.
10.1101/2021.07.29.454227 — cell biology — Posted on 2021-11-07
3024 Discovery of an Antarctic ascidian-associated uncultivated Verrucomicrobia with antimelanoma palmerolide biosynthetic potential
Murray, A. E.; Lo, C.-C.; Daligault, H.; Avalon, N. E.; Read, R. W.; Davenport, K. W.; Higham, M. L.; Kunde, Y.; Dichosa, A. E. K.; Baker, B. J.; Chain, P. S. G.
10.1101/2021.05.05.442870 — microbiology — Posted on 2021-11-07
3025 Enteroendocrine cell types that drive food reward and aversion
Bai, L.; Sivakumar, N.; Mesgarzadeh, S.; Ding, T.; Ly, T.; Corpuz, T. V.; Grove, J. C. R.; Jarvie, B. C.; Knight, Z. A.
10.1101/2021.11.05.467492 — physiology — Posted on 2021-11-07
3028 Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri
Shippy, T.; Miller, S.; Tamayo, B.; Hosmani, P. S.; Flores-Gonzalez, M.; Mueller, L. A.; Hunter, W. B.; Brown, S. J.; D'Elia, T.; Saha, S.
10.1101/2021.10.30.466601 — bioinformatics — Posted on 2021-11-07
3030 A comprehensive series of temporal transcription factors in the fly visual system
Konstantinides, N.; Rossi, A. M.; Escobar, A.; Dudragne, L.; Chen, Y.-C.; Tran, T.; Jaimes, A. M.; Ozel, M. N.; Simon, F.; Shao, Z.; Tsankova, N. M.; Fullard, J. F.; Walldorf, U.; Roussos, P.; Desplan, C.
10.1101/2021.06.13.448242 — developmental biology — Posted on 2021-11-07
3033 Deficiency of p38&α-MAPK in myeloid cells ameliorates symptoms and pathology of APP-transgenic AD mice
Luo, Q.; Schnöder, L.; Hao, W.; Litzenburger, K.; Decker, Y.; Tomic, I.; Menger, M.; Fassbender, K.; Liu, Y.
10.1101/2021.10.18.464870 — neuroscience — Posted on 2021-11-07
3035 Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition for drought tolerance in Arabidopsis
Shukla, A.; Kaur, M.; Kanwar, S.; Kaur, G.; Sharma, S.; Ganguli, S.; Kumari, V.; Mazumder, K.; Pandey, P.; Rouached, H.; Rishi, V.; Bhandari, R.; Pandey, A. K.
10.1101/743294 — plant biology — Posted on 2021-11-06
3036 Deep Learning Achieves Neuroradiologist-Level Performance in Detecting Hydrocephalus Requiring Treatment
Huang, Y.; Moreno, R.; Malani, R.; Meng, A.; Swinburne, N.; Holodny, A. I.; Choi, Y.; Parra, L. C.; Young, R. J.
10.1101/2021.01.19.427328 — bioinformatics — Posted on 2021-11-07
3038 A toolkit to generate inducible and interconvertible Drosophila overexpression transgenes
Wendler, F.; Park, S.; Hill, C.; Galasso, A.; Chang, K. R.; Awan, I.; Sudarikova, Y.; Bustamante, M.; Liu, S.; Sung, E.; Aisabonoko, G.; Kim, S. K.; Lopez, L. A. B.
10.1101/2020.08.18.256461 — genetics — Posted on 2021-11-07
3039 Multiple spillovers and onward transmission of SARS-Cov-2 in free-living and captive White-tailed deer
Kuchipudi, S. V.; Surendran-Nair, M.; Ruden, R. M.; Yon, M.; Nissly, R. H.; Nelli, R. K.; Li, L.; Jayarao, B. M.; Vandegrift, K.; Maranas, C. D.; Levine, N.; Willgert, K.; Conlan, A. J. K.; Olsen, R. J.; Davis, J.; Musser, J. M.; Hudson, P. J.; Kapur, V.
10.1101/2021.10.31.466677 — microbiology — Posted on 2021-11-06
3042 SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
Samsudin, F.; Raghuvamsi, P.; Petruk, G.; Puthia, M.; Petrlova, J.; MacAry, P.; Anand, G. S.; Schmidtchen, A.; Bond, P. J.
10.1101/2021.10.29.466401 — microbiology — Posted on 2021-11-06
3043 PHOSPHATE STARVATION RESPONSE enables arbuscular mycorrhiza symbiosis
Das, D.; Paries, M.; Hobecker, K.; Gigl, M.; Dawid, C.; Lam, H.-M.; Zhang, J.; Chen, M.; Gutjahr, C.
10.1101/2021.11.05.467437 — plant biology — Posted on 2021-11-06
3050 Cooperativity mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites
Jezewski, A. J.; Guggisberg, A. M.; Hodge, D. M.; Ghebremichael, N.; McLellan, L. K.; Odom John, A. R.
10.1101/2021.11.05.467329 — microbiology — Posted on 2021-11-06
3051 Bacterial chemotaxis to saccharides is governed by a trade-off between sensing and uptake
Norris, N.; Alcolombri, U.; Keegstra, J. M.; Yawata, Y.; Menolascina, F.; Frazzoli, E.; Levine, N. M.; Fernandez, V. I.; Stocker, R.
10.1101/2021.11.05.467490 — microbiology — Posted on 2021-11-06
3052 Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium
Wang, J.; Lareau, C. A.; Bautista, J. L.; Gupta, A. R.; Sandor, K.; Germino, J.; Yin, Y.; Arvedson, M. P.; Reeder, G. C.; Cramer, N. T.; Xie, F.; Ntranos, V.; Satpathy, A. T.; Anderson, M. S.; Gardner, J. M.
10.1101/2021.11.05.467513 — immunology — Posted on 2021-11-06
3053 Association of cochlear outer hair cell - type II spiral ganglion afferents with protection from noise-induced hearing loss
Cederholm, J. M. E.; Parley, K. E.; Perera, C. J.; Jonquieres, G. v.; Pinyon, J. L.; Julien, J.-P.; Ryugo, D. K.; Ryan, A. F.; Housley, G. D.
10.1101/2021.11.06.467554 — neuroscience — Posted on 2021-11-06
3054 Discrete-to-analog signal conversion in human pluripotent stem cells
Prochazka, L.; Zandstra, P. W.; Michaels, Y. S.; Lau, C.; Siu, M.; Yin, T.; Wu, D.; Jang, E.; Jones, R. D.; Vazquez-Cantu, M.; Gilbert, P. M.; Kaul, H.; Benenson, Y.
10.1101/2021.11.05.467377 — synthetic biology — Posted on 2021-11-06
3057 The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix
Herrera, J. A.; Dingle, L.; Montero, M. A.; Shah, R.; Venkateswaran, R. V.; Blaikley, J. F.; Lawless, C.; Schwartz, M. A.
10.1101/2021.11.06.467549 — pathology — Posted on 2021-11-06
3058 Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells
MAURA, F.; Ziccheddu, B.; Xiang, J. J.; Bhinder, B.; Abascal, F.; Maclachlan, K.; Eng, K. W.; Uppal, M.; He, F.; Zhang, W.; Gao, Q.; Yellapantula, V.; Park, S.; Oberley, M.; Ruckdeschel, E.; Lim, M. S.; Wertheim, G.; Barth, M.; Horton, T. M.; Forlenza, C.; Zhang, Y.; Landgren, O.; Moskowitz, C. H.; Cesarman, E.; Imielinski, M.; Elemento, O.; Roshal, M.; Giulino-Roth, L.
10.1101/2021.11.05.467496 — cancer biology — Posted on 2021-11-06
3059 Large-scale discovery of recombinases for integrating DNA into the human genome
Durrant, M. G.; Fanton, A.; Tycko, J.; Hinks, M.; Chandrasekaran, S.; Perry, N. T.; Schaepe, J.; Du, P. P.; Bintu, L.; Bassik, M. C.; Bhatt, A. S.; Hsu, P. D.
10.1101/2021.11.05.467528 — bioengineering — Posted on 2021-11-06
3060 Accelerated Bone Healing in Calvarial and Femoral Defects with Injectable Microcarriers that Mimic the Osteogenic Niche
Haase, C.; Jaligama, S.; Mondragon, E.; Pan, S.; McNeill, E. H.; Co, C.; Tahan, D.; Clough, B. H.; Sears, N.; Dominic, A.; Kameoka, J.; Gregory, C.; Kaunas, R.
10.1101/2021.11.05.467478 — bioengineering — Posted on 2021-11-06
3062 Parent-of-origin effects in the UK Biobank
Hofmeister, R. J.; Rubinacci, S.; Ribeiro, D. M.; Kutalik, Z.; Buil, A.; Delaneau, O.
10.1101/2021.11.03.467079 — genomics — Posted on 2021-11-06
3063 Whole-genome sequencing of Chinese native goat offers biological insights into cashmere fiber formation
Han, H.; Yang, M.-M.; Jiang, D.; Zhang, X.-J.; Wei, Q.; Chen, T.; Wang, Q.-J.; Yang, C.-Y.; Wulan, B.; Zhang, T.-T.; Gang, G.; Mengke, D.; LI, B.; Deng, W.-D.; Miao, Z.-P.; Wang, R.; Zhang, Q.-F.; Li, L.; CHao, S.-Y.; Fang, M.; Li, Y.
10.1101/2021.11.06.467539 — genomics — Posted on 2021-11-06
3065 Structure and Function of the Retina of Low-density Lipoprotein Receptor-related Protein 5 (Lrp5)-deficient Rats
Ubels, J. L.; Lin, C.-M.; Antonetti, D. A.; Diaz-Coranguez, M.; Diegel, C. R.; Williams, B. O.
10.1101/2021.11.05.467506 — genetics — Posted on 2021-11-06
3067 Reconstructing the Origins of a Neuropeptide Signaling System Using the Accelerated Evolution of Biodiverse Cone Snail Venoms
Koch, T. L.; Ramiro, I. B. L.; Florez-Salcedo, P.; Engholm, E.; Jensen, K. J.; Chase, K.; Olivera, B. M.; Bjorn-Yoshimoto, W. E.; Safavi-Hemami, H.
10.1101/2021.11.05.463867 — evolutionary biology — Posted on 2021-11-06
3069 Transcriptional regulation of sphingolipid metabolism in budding yeast
Komatsu, N.; Ishino, Y.; Shirai, R.; Sakata, K.-t.; Tani, M.; Maeda, T.; Tanaka, N.; Tabuchi, M.
10.1101/2021.11.05.467429 — cell biology — Posted on 2021-11-06
3070 Construction of lux-based promoter-reporter platforms in Mycobacterium bovis BCG for screening of drug repurposing small-molecule compounds as new anti-tuberculosis drugs
Zhu, L.; Lee, A. W.-t.; WU, K. K.-L.; GAO, P.; Tam, K. K.-G.; Rajwani, R.; CHABURTE, G. C.; NG, T. T.-L.; Chan, C. T. M.; Lao, H.-Y.; Yam, W.-C.; Kao, R. Y.-T.; Siu, G. K. H.
10.1101/2021.11.05.467536 — microbiology — Posted on 2021-11-06
3071 Malaria transmission relies on concavin-mediated maintenance of Plasmodium sporozoite cell shape
Kehrer, J.; Formaglio, P.; Muthinja, J. M.; Weber, S.; Baltissen, D.; Lance, C.; Ripp, J.; Grech, J.; Meissner, M.; Funaya, C.; Amino, R.; Frischknecht, F.
10.1101/2021.11.06.467543 — microbiology — Posted on 2021-11-06
3072 Natural variation in root exudation of GABA and DIMBOA impacts the maize root endosphere and rhizosphere microbiomes
Wang, P.; Lopez, L. D.; Alvarez, S.; Lopez-Guerrero, M.; van Dijk, K.; Riethoven, J.-J.; Schachtman, D.
10.1101/2021.11.05.467511 — microbiology — Posted on 2021-11-06
3073 Functional characterization of mutants deficient in N-terminal phosphorylation of the CF1 subunit beta
Bock, R.; Strand, D. D.; Karcher, D.; Ruf, S.; Schadach, A.; Schöttler, M. A.; Sandoval-Ibanez, O.
10.1101/2021.11.04.467332 — plant biology — Posted on 2021-11-06
3076 Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175
Oh, S.; Marinelli, F.; Zhou, W.; Lee, J.; Choi, H. J.; Kim, M.; Faraldo-Gomez, J. D.; Hite, R. K.
10.1101/2021.11.05.467414 — biophysics — Posted on 2021-11-06
3077 Protamine lacking piscine spermatozoa are transcriptionally active
Castro-Arnau, J.; Chauvigne, F.; Gomez-Garrido, J.; Esteve-Codina, A.; Dabad, M.; Aliotto, T.; Finn, R. N.; Cerda, J.
10.1101/2021.11.05.467500 — cell biology — Posted on 2021-11-06
3078 Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
Balasubramanian, S.; Andreani, M.; Andrade, J. G.; Saha, T.; Garzon, J.; Zhang, W.; Rahjouei, A.; Rosen, D. B.; Chait, B. T.; Donaldson, A. D.; Di Virgilio, M.
10.1101/2021.11.04.467328 — molecular biology — Posted on 2021-11-06
3079 Constant rate of Plasmodium falciparum sexual commitment promotes variable gametocyte proportions as infection progresses over time
Portugal, S.; van Dijk, H.; Ferreira Lima, N.; Kampmann, M.; Gabel, M.; Dabbas, U.; Doumbo, S.; Cisse, H.; Li, S.; Jeninga, M.; Thomson Luque, R.; Doumtabe, D.; Petter, M.; Kayentao, K.; Ongoiba, A.; Bousema, T.; Crompton, P. D.; Traore, B.; Graw, F.
10.1101/2021.11.05.467456 — microbiology — Posted on 2021-11-06
3081 Octopamine drives honeybee thermogenesis
Kaya-Zeeb, S.; Engelmayer, L.; Bayer, J.; Bähre, H.; Seifert, R.; Scherf-Clavel, O.; Thamm, M.
10.1101/2021.11.04.467276 — neuroscience — Posted on 2021-11-06
3084 Selenium in wheat from farming to food
Wang, M.; Li, B.; Li, S.; Song, Z.; Kong, F.; Zhang, X.
10.1101/2021.07.17.452805 — plant biology — Posted on 2021-11-06
3088 Protective Effects of Edaravone Against Hypoxia-Induced Lethality in Male Swiss Albino Mice
Shaki, F.; Shamshirian, A.; Raei, M.; Mokhtaran, M.; Eslami, S.; Shamshirian, D.; Ebrahimzadeh, M. A.
10.1101/2020.05.22.111401 — pharmacology and toxicology — Posted on 2021-11-06
3091 Artificial Neural Networks for classification of single cell gene expression
Zhong, J.; Lyu, M.; Jin, H.; Cao, Z.; Chitkushev, L. T.; Zhang, G.; Keskin, D. B.; Brusic, V.
10.1101/2021.07.29.454293 — bioinformatics — Posted on 2021-11-06
3093 Comprehensive assessment of Indian variations in the druggable kinome landscape highlights distinct insights at the sequence, structure and pharmacogenomic stratum
Panda, G.; Mishra, N.; Sharma, D.; Kutum, R.; Bhoyar, R. C.; Jain, A.; Imran, M.; Senthilvel, V.; Divakar, M. K.; Mishra, A.; Garg, P.; Banerjee, P.; Sivasubbu, S.; Scaria, V.; Ray, A.
10.1101/2021.05.23.445314 — genomics — Posted on 2021-11-06
3094 Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits
Olasege, B. S.; Porto-Neto, L. R.; Tahir, M. S.; Gouveia, G. C.; Canovas, A.; Hayes, B.; Fortes, M.
10.1101/2021.11.05.467409 — genetics — Posted on 2021-11-06
3099 Modeling How Community Assembly Alters the Functioning of Ecosystems
Koffel, T.; Kremer, C. T.; Bannar-Martin, K.; Ernest, M. S. K.; Eisenhauer, N.; Roscher, C.; Sarmento Cabral, J.; Leibold, M. A.
10.1101/2020.02.10.942656 — ecology — Posted on 2021-11-06
3100 Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation
Hanna, C. W.; Huang, J.; Belton, C.; Reinhardt, S.; Dahl, A.; Andrews, S.; Stewart, A. F.; Kranz, A.; Kelsey, G.
10.1101/2021.03.11.434836 — developmental biology — Posted on 2021-11-06
3102 Increasing cell size remodels the proteome and promotes senescence
Lanz, M. C.; Zatulovskiy, E.; Swaffer, M. P.; Zhang, L.; Ilerten, I.; Zhang, S.; You, D. S.; Marinov, G. K.; McAlpine, P.; Elias, J. E.; Skotheim, J. M.
10.1101/2021.07.29.454227 — cell biology — Posted on 2021-11-06
3103 Sulfite preservatives effects on the mouth microbiome: changes in viability, diversity and composition of microbiota
Irwin, S.; Deardorf, L. M.; Deng, Y.; Fisher, P.; Gould, M.; June, J.; Kent, R.; Qin, Y.; Yadao, F.
10.1101/2021.11.04.467028 — microbiology — Posted on 2021-11-06
3104 Thymic macrophages consist of two populations with distinct localization and origin
Zhou, T.-A.; Hsu, H.-P.; Tu, Y.-H.; Lin, C.-Y.; Chen, N.-J.; Tsai, J.-W.; Robey, E. A.; Huang, H.-C.; Hsu, C.-L.; Dzhagalov, I. L.
10.1101/2021.11.04.467238 — immunology — Posted on 2021-11-06
3105 A neural surveyor to map touch on the body
Miller, L.; Fabio, C.; Azaroual, M.; Muret, D.; van Beers, R.; Farne, A.; Medendorp, W. P.
10.1101/2020.06.26.173419 — neuroscience — Posted on 2021-11-06
3112 Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts
Peptropoulou-Vathi, L.; Simitsi, A. M.; Valkimadi, P.-E.; Kedariti, M.; Dimitrakopoulos, L.; Koros, C.; Papadimitriou, D.; Papadimitriou, A.; Stefanis, L.; Alcalay, R. N.; Rideout, H. J.
10.1101/2021.11.05.465894 — neuroscience — Posted on 2021-11-05
3115 Affinity sedimentation and magnetic separation with plant-made immunosorbent nanoparticles for therapeutic protein purification
McNulty, M. J.; Schwartz, A.; Delzio, J.; Karuppanan, K.; Jacobson, A.; Hart, O.; Dandekar, A.; Giritch, A.; Nandi, S.; Gleba, Y.; McDonald, K. A.
10.1101/2021.11.05.467285 — bioengineering — Posted on 2021-11-05
3116 Discovery of a carbonic anhydrase-Rubisco supercomplex within the alpha-carboxysome
Blikstad, C.; Dugan, E. J.; Laughlin, T. G.; Liu, M. D.; Shoemaker, S. R.; Remis, J. P.; Savage, D. F.
10.1101/2021.11.05.467472 — biochemistry — Posted on 2021-11-05
3117 Ancient genomes from the last three millennia support multiple human dispersals into Wallacea
Oliveira, S.; Nägele, K.; Carlhoff, S.; Pugach, I.; Koesbardiati, T.; Hübner, A.; Meyer, M.; Oktaviana, A. A.; Takenaka, M.; Katagiri, C.; Murti, D. B.; Putri, R. S.; Mahirta, ; Higham, T.; Higham, C. F. W.; O'Connor, S.; Hawkins, S.; Kinaston, R.; Bellwood, P.; Ono, R.; Powell, A.; Krause, J.; Posth, C.; Stoneking, M.
10.1101/2021.11.05.467435 — genomics — Posted on 2021-11-05
3120 Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli
Kwasi, D. A.; Babalola, C. P.; Olubiyi, O. O.; Hoffmann, J.; Uzochukwu, I.; Okeke, I. N.
10.1101/2021.11.05.467448 — microbiology — Posted on 2021-11-05
3121 Outer Membrane Vesicles from the gut microbiome contribute to tumor immunity by eliciting cross-reactive T cells
Tomasi, M.; Caproni, E.; Benedet, M.; Zanella, I.; Giorgetta, S.; Dalsass, M.; Koenig, E.; Gagliardi, A.; Fantappie', L.; Berti, A.; Tamburini, S.; Croia, L.; Di Lascio, G.; Bellini, E.; Valensin, S.; Licata, G.; Sebastiani, G.; Dotta, F.; Armanini, F.; Cumbo, F.; Asnicar, F.; Blanco-Miguez, A.; Ruggiero, E.; Segata, N.; Grandi, A.; Grandi, G.
10.1101/2021.11.05.467432 — microbiology — Posted on 2021-11-05
3123 Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
Aznaourova, M.; Schmerer, N.; Janga, H.; Zhang, Z.; Pauck, K.; Hoppe, J.; Volkers, S. M.; Wendisch, D.; Georg, P.; Guendisch, M.; Mack, E.; Skevaki, C.; Keller, C.; Bauer, C.; Bertrams, W.; Nist, A.; Stiewe, T.; Gruber, A. D.; Ruppert, C.; Li, Y.; Garn, H.; Sander, L. E.; Schmeck, B.; Schulte, L. N.
10.1101/2021.11.05.467458 — immunology — Posted on 2021-11-05
3125 Enteroendocrine cell types that drive food reward and aversion
Knight, Z. A.; Bai, L.; Sivakumar, N.; Mesgarzadeh, S.; Ding, T.; Ly, T.; Corpuz, T. V.; Grove, J. C. R.; Jarvie, B. C.
10.1101/2021.11.05.467492 — physiology — Posted on 2021-11-05
3129 Discovery of imidazole-based inhibitors of P. falciparum cGMP-dependent protein kinase
Yadav, R. R.; de Souza, M. L.; Gonzalez, M. L.; Mahmood, S. U.; Eck, T.; Kreiss, T.; Aylor, S. O.; Roth, A.; Lee, P.; Pybus, B. S.; Colussi, D. J.; Childers, W. E.; Gordon, J.; Siekierka, J. J.; Bhanot, P.; Rotella, D. P.
10.1101/2021.11.05.467463 — pharmacology and toxicology — Posted on 2021-11-05
3132 A truncated reverse transcriptase enhances prime editing by split AAV vectors
Gao, Z.; Haldrup, J.; Ravendran, S.; Mikkelsen, N. S.; Mikkelsen, J. G.; Bak, R. O.
10.1101/2021.11.05.467423 — genetics — Posted on 2021-11-05
3133 CALDERA: Finding all significant de Bruijn subgraphs for bacterial GWAS
Roux de Bezieux, H.; Lima, L.; Perraudeau, F.; Mary, A.; Dudoit, S.; Jacob, L.
10.1101/2021.11.05.467462 — genetics — Posted on 2021-11-05
3134 Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits
Olasege, B. S.; Porto-Neto, L. R.; Tahir, M. S.; Gouveia, G. C.; Canovas, A.; Hayes, B.; Fortes, M.
10.1101/2021.11.05.467409 — genetics — Posted on 2021-11-05
3135 Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally
Mertens, J.; Regin, M.; De Munck, N.; Couvreu de Deckersberg, E.; Belva, F.; Sermon, K. D.; Tournaye, H.; Blockeel, C.; Van de Velde, H.; Spits, C.
10.1101/2021.11.05.467445 — genetics — Posted on 2021-11-05
3136 A novel enhancer of Agouti contributes to parallel evolution of cryptically colored beach mice
Wooldridge, T. B.; Kautt, A. F.; Lassance, J.-M.; McFadden, S. S.; Domingues, V. S.; Mallarino, R.; Hoekstra, H. E.
10.1101/2021.11.05.467454 — evolutionary biology — Posted on 2021-11-05
3138 Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen
Bass, J.; Marcheva, B.; Weidemann, B. J.; Taguchi, A.; Perelis, M.; Ramsey, K. M.; Newman, M. V.; Kobayashi, Y.; Omura, C.; Manning Fox, J. E.; Lin, H.; Macdonald, P. E.
10.1101/2021.11.05.467499 — cell biology — Posted on 2021-11-05
3139 SARS-CoV-2 infection in free-ranging white-tailed deer (Odocoileus virginianus)
Hale, V. L.; Dennis, P. M.; McBride, D. S.; Nolting, J. M.; Madden, C.; Huey, D.; Ehrlich, M.; Grieser, J.; Winston, J. A.; Lombardi, D.; Gibson, S.; Saif, L.; Killian, M. L.; Lantz, K.; Tell, R. M.; Torchetti, M. K.; Robbe-Austerman, S.; Nelson, M. I.; Faith, S. A.; Bowman, A.
10.1101/2021.11.04.467308 — molecular biology — Posted on 2021-11-05
3140 Turnover in life strategies recapitulates microbial succession on synthetic marine particles
Pascual-Garcia, A.; Schwartzman, J.; Enke, T. N.; Iffland-Stettner, A.; Cordero, O. X.; Bonhoeffer, S.
10.1101/2021.11.05.466518 — microbiology — Posted on 2021-11-05
3141 Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice
Hu, Z.; Sun, R.; Zhao, Z.; Fu, C.; Wang, Y.; Guo, Z.; Zhang, C.; Liu, L.; Zhang, C.; Shu, C.; He, J.; Li, W.; Zhou, Q.; Gao, Y.; Hua, S.; Yang, Y.-G.
10.1101/2021.11.05.466755 — immunology — Posted on 2021-11-05
3143 Sexual reproduction contributes to the evolution of resistance breaking isolates of the spinach pathogen Peronospora effusa
Skiadas, P.; Klein, J.; Quiroz Monnens, T.; Elberse, J.; de Jonge, R.; Van den Ackerveken, G.; Seidl, M. F.
10.1101/2021.11.05.467349 — evolutionary biology — Posted on 2021-11-05
3145 A novel whole yeast-based subunit oral vaccine against Eimeria tenella in chickens
Soutter, F.; Werling, D.; Nolan, M. J.; Kuester, T.; Atree, E.; Marugan-Hernandez, V.; Kim, S.; Tomley, F.; Blake, D. P.
10.1101/2021.11.05.467441 — immunology — Posted on 2021-11-05
3147 TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Demirdizen, E.; Al-Ali, R.; Narayanan, A.; Sun, X.; Varga, J. P.; Steffl, B.; Brom, M.; Krunic, D.; Schmidt, C.; Schmidt, G.; Bestvater, F.; Taranda, J.; Turcan, S.
10.1101/2021.11.05.467405 — cancer biology — Posted on 2021-11-05
3148 Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants
Zarn, K. E.; Jaramillo, S. A.; Zapata, A. R.; Stone, N. E.; Jones, A. N.; Nunnally, H. E.; Settles, E. W.; Ng, K.; Keim, P. S.; Knudsen, S.; Nuijten, P. M.; Tijsma, A. S.; French, C. T.
10.1101/2021.11.03.467186 — microbiology — Posted on 2021-11-05
3149 Increased Occurrence of Treponema spp. and Double-species Infections in Patients with Alzheimer's Disease
Nemergut, M.; Batkova, T.; Vigasova, D.; Bartos, M.; Hlozankova, M.; Schenkmayerova, A.; Liskova, V.; Sheardova, K.; Vyhnalek, M.; Hort, J.; Laczo, J.; Kovacova, I.; Sitina, M.; Matej, R.; Jancalek, R.; Marek, M.; Damborsky, J.
10.1101/2021.11.04.467230 — microbiology — Posted on 2021-11-05
3150 Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
Urata, S.; Kishimoto-Urata, M.; Kagoya, R.; Imamura, F.; Nagayama, S.; Reyna, R. A.; Maruyama, J.; Yamasoba, T.; Kondo, K.; Hasegawa-Ishii, S.; Paessler, S.
10.1101/2021.11.04.467274 — neuroscience — Posted on 2021-11-05
3151 Assessment of AI-based Protein Structure Prediction for the NLRP3 Target
Yin, J.; Yu, J.; Cui, W.; Lei, J.; Chen, W.; Satz, A. L.; Zhou, Y.; Feng, H.; Deng, J.; Su, W.; Kuai, L.
10.1101/2021.11.05.467381 — biochemistry — Posted on 2021-11-05
3153 Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes
Kluss, J. H.; Beilina, A.; Williamson, C. D.; Lewis, P. A.; Cookson, M. R.; Bonet-Ponce, L.
10.1101/2020.12.01.406223 — cell biology — Posted on 2021-11-05
3155 The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
Abdelnabi, R.; Foo, C. S.-Y.; Jochmans, D.; Vangeel, L.; De Jonghe, S.; Augustijns, P.; Mols, R.; Weynand, B.; Wattanakul, T.; Hoglund, R.; Tarning, J.; Mowbray, C.; Sjo, P.; Escudie, F.; Scandale, I.; Chatelain, E.; Neyts, J.
10.1101/2021.11.04.467077 — microbiology — Posted on 2021-11-05
3156 A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques
Yu, J.; Yao, W.; Hu, Y.; Wu, S.; Li, J.; Zhou, H.; Hong, K.; Chen, J.; Liu, L.; Lan, K.; Zhu, F.-C.; Liu, Y.
10.1101/2021.11.03.467182 — immunology — Posted on 2021-11-05
3157 Microstructural development from 9-14 years: evidence from the ABCD Study
Palmer, C. E.; Pecheva, D.; Iversen, J. R.; Hagler, D. J.; Sugrue, L.; Nedelec, P.; Fan, C.; Thompson, W.; Jernigan, T. L.; Dale, A. M.
10.1101/2021.06.04.447102 — neuroscience — Posted on 2021-11-05
3159 Paradoxes and synergies: optimizing management of a deadly virus in an endangered carnivore
Gilbertson, M. L. J.; Onorato, D.; Cunningham, M. W.; VandeWoude, S.; Craft, M. E.
10.1101/2021.01.11.426249 — ecology — Posted on 2021-11-05
3160 A vacuolar hexose transport is required for xylem development in the inflorescence stem of Arabidopsis.
Aubry, E.; Hoffmann, B.; Vilaine, F.; Gilard, F.; Klemens, P. A. W.; Guerard, F.; Gakiere, B.; Neuhaus, H. E.; Bellini, C.; Dinant, S.; Le Hir, R.
10.1101/2020.12.09.417345 — plant biology — Posted on 2021-11-05
3161 Creatine transporter deficient rat model show motor dysfunction, cerebellar alterations and muscle creatine deficiency without muscle atrophy
Duran-Trio, L.; Fernandes-Pires, G.; Grosse, J.; Soro-Arnaiz, I.; Roux-Petronelli, C.; Binz, P.-A.; De Bock, K.; Cudalbu, C.; Sandi, C.; Braissant, O.
10.1101/2021.10.12.464080 — pathology — Posted on 2021-11-05
3163 Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndrome
Catarinella, G.; Nicoletti, C.; Bracaglia, A.; Procopio, P.; Salvatori, I.; Taggi, M.; Ferri, A.; Valle, C.; Canipari, R.; Puri, P. L.; Latella, L.
10.1101/2021.11.05.467259 — cell biology — Posted on 2021-11-05
3164 Microbial adaptation to venom is common in snakes and spiders
Esmaeilishirazifard, E.; Usher, L.; Trim, C.; Denise, H.; Sangal, V.; Tyson, G. H.; Barlow, A.; Redway, K.; Taylor, J. D.; Kremmyda-Vlachou, M.; Davies, S.; Loftus, T. D.; Lock, M. M. G.; Wright, K.; Dalby, A.; Snyder, L. A. S.; Wuster, W.; Trim, S.; Moschos, S. A.
10.1101/348433 — microbiology — Posted on 2021-11-05
3168 Rational control of structural off-state heterogeneity in a photoswitchable fluorescent protein provides switching contrast enhancement
Adam, V.; Hadjidemetriou, K.; Jensen, N.; Shoeman, R. L.; Woodhouse, J.; Aquila, A.; Banneville, A.-S.; Barends, T. R. M.; Bezchastnov, V.; Boutet, S.; Byrdin, M.; Cammarata, M.; Carbajo, S.; Christou, N.-E.; Coquelle, N.; De la Mora, E.; El Khatib, M.; Moreno Chicano, T.; Doak, R. B.; Fieschi, F.; Foucar, L.; Glushonkov, O.; Gorel, A.; Grunbein, M.-L.; Hilpert, M.; Hunter, M.; Kloos, M.; Koglin, J. E.; Lane, T. J.; Liang, M.; Mantovanelli, A.; Nass, K.; Nass Kovacs, G.; Owada, S.; Roome, C. M.; Schiro, G.; Seaberg, M.; Stricker, M.; Thepaut, M.; Tono, K.; Ueda, K.; Uriarte, L. M.; You, D.; Za
10.1101/2021.11.05.462999 — biophysics — Posted on 2021-11-05
3171 Genetic and chemotherapeutic causes of germline hypermutation
Kaplanis, J.; Ide, B.; Sanghvi, R.; Neville, M.; Danecek, P.; Coorens, T.; Prigmore, E.; Short, P.; Gallone, G.; McRae, J.; Odhams, C.; Moutsianas, L.; Genomics England Research Consortium, ; Carmichael, J.; Barnicoat, A.; Firth, H.; O'Brien, P.; Rahbari, R.; Hurles, M. E.
10.1101/2021.06.01.446180 — genomics — Posted on 2021-11-05
3172 A temporally resolved, multiplex molecular recorder based on sequential genome editing
Choi, J.; Chen, W.; Minkina, A.; Chardon, F. M.; Suiter, C. C.; Regalado, S. G.; Domcke, S.; Hamazaki, N.; Lee, C.; Martin, B.; Daza, R. M.; Shendure, J.
10.1101/2021.11.05.467388 — genomics — Posted on 2021-11-05
3173 Multiplex genomic recording of enhancer and signal transduction activity in mammalian cells
Chen, W.; Choi, J.; Nathans, J. F.; Agarwal, V.; Martin, B.; Nichols, E.; Leith, A.; Lee, C.; Shendure, J.
10.1101/2021.11.05.467434 — genomics — Posted on 2021-11-05
3176 Genotype-specific transcriptional responses overshadow salinity effects in a marine diatom sampled along the Baltic Sea salinity cline
Pinseel, E.; Nakov, T.; Van den Berge, K.; Downey, K. M.; Judy, K. J.; Kourtchenko, O.; Kremp, A.; Ruck, E. C.; Sjoqvist, C.; Topel, M.; Godhe, A.; Alverson, A. J.
10.1101/2021.11.04.467364 — microbiology — Posted on 2021-11-05
3177 Rational Designed Hybrid Peptides Show up to a 6-fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides measured by BioSAXS
Hilpert, K.; Gani, J.; Rumancev, C.; Simpson, N.; Lopez-Perez, P. M.; Garamus, V. M.; vonGundlach, A. R.; Markov, P.; Scocchi, M.; Mikut, R.; Rosenhahn, A.
10.1101/2021.11.05.467440 — microbiology — Posted on 2021-11-05
3178 Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases
Roostaei, T.; Diaconu, C.; Touil, H.; Harbison, C.; Zhang, Y.; Epstein, S.; Tuddenham, J.; Bryois, J.; Wiendl, H.; Meyer zu Hörste, G.; Malhotra, D.; Riley, C.; Menon, V.; De Jager, P. L.
10.1101/2021.11.01.466797 — immunology — Posted on 2021-11-05
3180 Organizing Principles of Astrocytic Nanoarchitecture in the Mouse Cerebral Cortex
Salmon, C. K.; Syed, T. A.; Kacerovsky, J. B.; Alivodej, N.; Schober, A. L.; Pratte, M. T.; Rosen, M. P.; Green, M.; Chirgwin-Dasgupta, A.; Vali, H.; Mandato, C. A.; Siddiqi, K.; Murai, K. K.
10.1101/2021.11.05.467391 — neuroscience — Posted on 2021-11-05
3181 An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning
Bohmbach, K.; Masala, N.; Schönhense, E. M.; Hill, K.; Haubrich, A. N.; Zimmer, A.; Opitz, T.; Beck, H.; Henneberger, C.
10.1101/2021.11.05.467400 — neuroscience — Posted on 2021-11-05
3183 Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data
Yamane, J.; Wada, T.; Otsuki, H.; Inomata, K.; Suzuki, M.; Hisaki, T.; Sekine, S.; Kouzuki, H.; Kobayashi, K.; Sone, H.; Yamashita, J. K.; Osawa, M.; Saito, M. K.; Fujibuchi, W.
10.1101/2021.11.05.466718 — pharmacology and toxicology — Posted on 2021-11-05
3186 Syotti: Scalable Bait Design for DNA Enrichment
Alanko, J.; Slizovskiy, I.; Lokshtanov, D.; Gagie, T.; Noyes, N.; Boucher, C.
10.1101/2021.11.05.467426 — bioinformatics — Posted on 2021-11-05
3188 Label-free prediction of Cell Painting from brightfield images
Cross-Zamirski, J. O.; Mouchet, E.; Williams, G.; Schönlieb, C.-B.; Turkki, R.; Wang, Y.
10.1101/2021.11.05.467394 — bioinformatics — Posted on 2021-11-05
3191 Hybridization and introgression are prevalent in Southern European Erysimum (Brassicaceae) species
Osuna-Mascaro, C.; Rubio de Casas, R.; Gomez, J. M.; Loureiro, J.; Castro, S.; Landis, J. B.; Hopkins, R.; Perfectti, F.
10.1101/2021.11.03.467125 — evolutionary biology — Posted on 2021-11-05
3194 Parental genomes segregate into different blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts
De Coster, T.; Masset, H.; Tsuiko, O.; Catteeuw, M.; Dierckxsens, N.; Debrock, S.; Peeraer, K.; Smits, K.; Van Soom, A.; Vermeesch, J.
10.1101/2021.11.05.467317 — developmental biology — Posted on 2021-11-05
3196 Chitin and cuticle proteins form the cuticular layer in the spinning duct of silk-spinning arthropods
Wang, X.; Xie, X.; Xie, K.; Liu, Q.; Li, Y.; Tan, X.; Dong, H.; Li, X.; Dong, Z.; Xia, Q.; Zhao, P.
10.1101/2021.11.04.466704 — molecular biology — Posted on 2021-11-05
3201 Hippocampal ghrelin signalling informs the decision to eat
Wee, R. W.; Mishchanchuk, K.; AlSubaie, R.; MacAskill, A. F.
10.1101/2021.11.05.467326 — neuroscience — Posted on 2021-11-05
3204 Mutant-SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms
Carratt, S. A.; Kong, G. L.; Smith, B. M.; Schonrock, Z.; Maloney, L.; Baris, A.; Druker, B. J.; Braun, T. P.; Maxson, J. E.
10.1101/2021.11.04.467367 — cancer biology — Posted on 2021-11-05
3207 OMAMO: orthology-based model organism selection
Nicheperovich, A.; Altenhoff, A. M.; Dessimoz, C.; Majidian, S.
10.1101/2021.11.04.467067 — bioinformatics — Posted on 2021-11-05
3209 The Human Eye Transcriptome Atlas: A Searchable Comparative Transcriptome Database for Healthy and Diseased Human Eye Tissue
Wolf, J.; Boneva, S.; Schlecht, A.; Lapp, T.; Auw-Haedrich, C.; Lagreze, W.; Agostini, H.; Reinhard, T.; Schlunck, G.; Lange, C.
10.1101/2021.11.04.467318 — bioinformatics — Posted on 2021-11-05
3210 De novo assembly of 20 chickens reveals the undetectable phenomenon for thousands of core genes on sub-telomeric regions
Li, M.; Sun, C.; Xu, N.; Bian, P.; Tian, X.; Wang, X.; Wang, Y.; Jia, X.; Heller, R.; Wang, M.; Wang, F.; Dai, X.; Luo, R.; Guo, Y.; Wang, X.; Yang, P.; Zhang, S.; Li, X.; Wen, C.; Lan, F.; SIDDIKI, A. Z.; Suwannapoom, C.; Zhao, X.; Nie, Q.; Hu, X.; Jiang, Y.; Yang, N.
10.1101/2021.11.05.467060 — genomics — Posted on 2021-11-05
3212 Genome-wide analysis of DNA methylation reveals selection signatures of the grass carp during domestication
Yu, E.; Li, Y.; Fu, B.; Zhang, J.; Xie, J.; Wang, G.; Tian, J.; Xia, Y.; Li, Z.; Li, H.; Jiang, P.
10.1101/2021.11.04.467282 — genetics — Posted on 2021-11-05
3214 The genetic population structure of Lake Tanganyika's Lates species flock, an endemic radiation of pelagic top predators
Rick, J. A.; Junker, J.; Kimirei, I. A.; Sweke, E. A.; Mosille, J. B.; Dinkel, C.; Mwaiko, S.; Seehausen, O.; Wagner, C. E.
10.1101/2021.04.23.441176 — evolutionary biology — Posted on 2021-11-05
3215 Long-term fungus-plant co-variation from multi-site sedimentary ancient DNA metabarcoding in Siberia
von Hippel, B.; Stoof-Leichsenring, K. R.; Schulte, L.; Seeber, P.; Epp, L. S.; Biskaborn, B. K.; Diekmann, B.; Melles, M.; Pestryakova, L.; Herzschuh, U.
10.1101/2021.11.05.465756 — ecology — Posted on 2021-11-05
3220 Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.
Harris, R.; Yang, M.; Schmidt, C.; Singh, S.; Natarajan, A.; Frezza, C.; Laman, H.
10.1101/2021.11.05.467417 — cell biology — Posted on 2021-11-05
3222 Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats
Qi, W.; Acosta Zaldivar, M.; Flanagan, P. R.; Liu, N.-N.; Jani, N.; Fierro, J. F.; Andres, M. T.; Moran, G. P.; Köhler, J. R.
10.1101/2021.11.05.467412 — microbiology — Posted on 2021-11-05
3225 Corticostriatal dynamics underlying components of binge-like eating in mice
Hildebrandt, B. A.; Fisher, H.; LaPalombara, Z.; Young, M. E.; Ahmari, S. E.
10.1101/2021.11.04.467011 — neuroscience — Posted on 2021-11-05
3230 Digital twin predicting diet response before and after long-term fasting
Arrestam, O.; Simonsson, C.; Ekstedt, M.; Lundberg, P.; Gennemark, P.; Cedersund, G.
10.1101/2021.11.04.467307 — systems biology — Posted on 2021-11-05
3232 Genome Mining Uncovers Clustered Biosynthetic Pathways for Defense-Related Molecules in Bread Wheat
Polturak, G.; Dippe, M.; Stephenson, M. J.; Misra, R. C.; Owen, C.; Ramirez-Gonzalez, R.; Haidoulis, J. F.; Schoonbeek, H.-j.; Chartrain, L.; Borrill, P.; Nelson, D. R.; Brown, J.; Nicholson, P.; Uauy, C.; Osbourn, A.
10.1101/2021.11.04.467362 — plant biology — Posted on 2021-11-05
3233 Variation in root exudate composition influences soil microbiome membership and function
Seitz, V. A.; McGivern, B. B.; Borton, M. A.; Chaparro, J. M.; Daly, R. A.; Sheflin, A. M.; Kresovich, S.; Shields, L.; Schipanski, M. E.; Wrighton, K. C.; Prenni, J.
10.1101/2021.11.04.467385 — plant biology — Posted on 2021-11-05
3234 Dynamics of peripheral blood flow across sleep stages
Fan, Z.; Suzuki, Y.; Jiang, L.; Okabe, S.; Honda, S.; Endo, J.; Watanabe, T.; Abe, T.
10.1101/2021.11.04.467081 — physiology — Posted on 2021-11-05
3235 AlphaFold Models Illuminate Half of Dark Human Proteins
Binder, J. L.; Berendzen, J.; Stevens, A. O.; He, Y.; Wang, J.; Dokholyan, N. V.; Oprea, T. I.
10.1101/2021.11.04.467322 — pharmacology and toxicology — Posted on 2021-11-05
3236 Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles
Tseng, H.-W.; Girard, D.; Alexander, K.; Millard, S.; Torossian, F.; Anginot, A.; Fleming, W.; Gueguen, J.; Goriot, M.-E.; Clay, D.; Jose, B.; Nowlan, B.; Pettit, A.; Salga, M.; Genet, F.; Bousse-Kerdiles, M.-C.; Banzet, S.; Levesque, J.-P.
10.1101/2021.11.04.467192 — pathology — Posted on 2021-11-05
3239 Dysfunction of exocytosis causes catecholamine hypersecretion in patient with pheochromocytoma
Houy, S.; Streit, L.; Drissa, I.; Rame, M.; Decraene, C.; Moog, S.; Brunaud, L.; Lanoix, J.; Chelbi, R.; Bihain, F.; Lacomme, S.; Lomazzi, S.; Vix, M.; Mutter, D.; Paramithiotis, E.; Dubessy, C.; Vitale, N.; Ory, S.; Gasman, S.
10.1101/2021.11.02.466874 — cancer biology — Posted on 2021-11-05
3241 A New Bioink For Improved 3D Bioprinting Of Bone-Like Constructs
Marsh, A.; Apu, E. H.; Bunn, M.; Contag, C. H.; Ashammakhi, N.; Chatzistavrou, X.
10.1101/2021.11.04.467312 — bioengineering — Posted on 2021-11-05
3243 Vocal tract allometry in a mammalian vocal learner
de Reus, K.; Carlson, D.; Lowry, A.; Gross, S.; Garcia, M.; Salazar Casals, A.; Rubio Garcia, A.; Ravignani, A.
10.1101/2021.10.29.466455 — animal behavior and cognition — Posted on 2021-11-05
3245 Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense
Wells, K. M.; He, K.; Pandey, A.; Cabello, A.; Zhang, D.; Yang, J.; Gomez, G.; Liu, Y.; Chang, H.; Li, X.; Zhang, H.; da Costa, L. F.; Metz, R.; D. Johnson, C.; Martin, C. L.; Skrobarczyk, J.; Berghman, L. R.; Patrick, K. L.; Leibowitz, J.; Ficht, A.; Sze, S.-H.; Qian, X.; Qin, Q.-M.; Ficht, T. A.; de Figueiredo, P.
10.1101/2021.11.04.467275 — microbiology — Posted on 2021-11-05
3246 Sulfite preservatives effects on the mouth microbiome: changes in viability, diversity and composition of microbiota
Irwin, S.; Deardorf, L. M.; Deng, Y.; Fisher, P.; Gould, M.; June, J.; Kent, R.; Qin, Y.; Yadao, F.
10.1101/2021.11.04.467028 — microbiology — Posted on 2021-11-05
3248 A comparative analysis of current phasing and imputation software
Yazdi, P. G.; De Marino, A.; Mahmoud, A. A.; Bose, M.; Bircan, K. O.; Terpolovsky, A.; Bamunusinghe, V.; Khan, U.; Novkovic, B.
10.1101/2021.11.04.467340 — genomics — Posted on 2021-11-04
3252 Next generation restoration metrics: Using soil eDNA bacterial community data to measure trajectories towards rehabilitation targets
Liddicoat, C.; Krauss, S. L.; Bissett, A.; Borrett, R. J.; Ducki, L. C.; Peddle, S. D.; Bullock, P.; Dobrowolski, M.; Grigg, A.; Tibbett, M.; Breed, M.
10.1101/2021.08.12.456018 — ecology — Posted on 2021-11-05
3253 Competitive dynamics underlie cognitive improvements during sleep.
Chen, P.-C.; Niknazar, H.; Alaynick, W. A.; Whitehurst, L. N.; Mednick, S. C.
10.1101/2021.03.31.437952 — neuroscience — Posted on 2021-11-05
3254 Catestatin induces glycogenesis by stimulating phosphoinositide 3-kinase-AKT pathway
Bandyopadhyay, G. K.; Tang, K.; Webster, N. J. G.; van den Bogaart, G.; Mahata, S. K.
10.1101/2020.10.31.363481 — physiology — Posted on 2021-11-05
3257 Chromosome splitting of Plasmodium berghei using the CRISPR/Cas9 system.
Addo-Gyan, D.; Matsushita, H.; Sora, E.; Nishi, T.; Shinzawa, N.; Yuda, M.; Iwanaga, S.
10.1101/2021.11.04.467339 — microbiology — Posted on 2021-11-04
3258 Wild birds as reservoirs of multidrug-resistant enterobacteria in Mulungu, Brazil
Beleza, A. J. F.; Maciel, W. C.; Carreira, A. S.; Marques, A. R.; Nogueira, C. H. G.; Pascoal Filho, N. M.; Lima, B. P.; Silva, I. N. G. d.; Vasconcelos, R. H.; Ribeiro, L. R.; Teixeira, R. S. d. C.
10.1101/2021.11.04.467336 — microbiology — Posted on 2021-11-04
3262 Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control
Tan, X.; Worley, J.; Turunen, M.; Wong, K.; Fernandez, E. C.; Paull, E.; Jones, S.; Wang, J.; Noh, H.; Salvatori, B.; Chavez, A.; Califano, A.
10.1101/2021.06.28.449297 — systems biology — Posted on 2021-11-04
3265 Exploration and analysis of R-loop mapping data with RLBase
Miller, H.; Montemayor, D.; Li, J.; Levy, S.; Pawar, R.; Hartono, S. R.; Sharma, K.; Frost, B.; Chedin, F.; Bishop, A. J.
10.1101/2021.11.01.466854 — bioinformatics — Posted on 2021-11-04
3266 Evaluation of CRISPR gene-editing tools in zebrafish
Uribe-Salazar, J. M.; Kaya, G.; Sekar, A.; Weyenberg, K.; Ingamells, C.; Dennis, M. Y.
10.1101/2020.10.19.345256 — genetics — Posted on 2021-11-04
3267 Genome-wide association study of cerebellar volume
Tissink, E.; de Lange, S. C.; Savage, J. E.; Wightman, D. P.; Kelly, K.; Nagel, M.; van den Heuvel, M. P.; Posthuma, D.
10.1101/2021.11.04.467250 — genetics — Posted on 2021-11-04
3269 Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce a symmetric gait
Lu, Y.; Ahamed, T.; Mulcahy, B.; Witvliet, D.; Guan, S. A.; Hung, W.; Meng, J.; Wen, Q.; Samuel, A.; Zhen, M.
10.1101/2021.09.21.461278 — neuroscience — Posted on 2021-11-04
3270 A positively tuned voltage indicator reveals electrical correlates of calcium activity in the brain
Evans, S. W.; Shi, D.; Chavarha, M.; Plitt, M. H.; Taxidis, J.; Madruga, B.; Fan, J. L.; Hwang, F.-J.; Van Keulen, S. C.; Suomivuori, C.-M.; Pang, M.; Su, S.; Zhang, G.; Lee, S.; Jiang, D.; Pradhan, L.; Liu, Y.; Reese, A.; Negrean, A.; Losonczy, A.; Makinson, C. D.; Wang, S.; Clandinin, T.; Dror, R.; Ding, J. B.; Ji, N.; Golshani, P.; Giocomo, L. M.; Bi, G. G.; Lin, M. Z.
10.1101/2021.10.21.465345 — neuroscience — Posted on 2021-11-04
3275 Absence of enterotypes in the human gut microbiomes reanalyzed with non-linear dimensionality reduction methods
Bulygin, I.; Shatov, V.; Rykachevsky, A.; Rayko, A.; Bernstein, A.; Burnaev, E.; Gelfand, M. S.
10.1101/2021.11.04.467087 — bioinformatics — Posted on 2021-11-04
3278 Quality-controlled R-loop meta-analysis reveals the characteristics of R-Loop consensus regions
Miller, H.; Montemayor, D.; Abdul, J.; Levy, S.; Hartono, S. R.; Vines, A.; Sharma, K.; Frost, B.; Chedin, F.; Bishop, A. J.
10.1101/2021.11.01.466823 — bioinformatics — Posted on 2021-11-04
3280 The Effect of A1/A2 Reactive Astrocyte Expression on Hydrocephalus Shunt Failure
Khodadadei, F.; Arshad, R.; Morales, D.; Gluski, J.; Marupudi, N.; McAllister, J.; Limbrick, D.; Harris, C.
10.1101/2021.11.04.467357 — bioengineering — Posted on 2021-11-04
3281 Machine learning-based library design improves packaging and diversity of adeno-associated virus (AAV) libraries
ZHU, D.; Brookes, D. H.; Busia, A.; Carneiro, A.; Fannjiang, C.; Popova, G.; Shin, D.; Chang, E. F.; Nowakowski, T. J.; Listgarten, J.; Schaffer, D. V.
10.1101/2021.11.02.467003 — bioengineering — Posted on 2021-11-04
3285 Rapid ecological and evolutionary divergence during a poleward range expansion
Sheffer, M. M.; Zander, L.; Schulze, B.; Mouginot, P.; Naef, T.; Kreyling, J.; Gillespie, R. G.; Hoff, K. J.; Prost, S.; Krehenwinkel, H.; Uhl, G.
10.1101/2021.11.04.467261 — ecology — Posted on 2021-11-04
3286 Selecting species for restoration in foundational assemblages
Madin, J.; McWilliam, M.; Quigley, K.; Bay, L.; Bellwood, D.; Bridge, T.; Doropoulos, C.; Fernandes, L.; Harrison, P.; Hoey, A.; Mumby, P.; Richards, Z.; Riginos, C.; Suggett, D.; van Oppen, M.
10.1101/2021.11.03.467181 — ecology — Posted on 2021-11-04
3299 Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants by Modular, Tetravalent, Bi-paratopic Antibodies
Miersch, S.; Saberianfar, R.; Chen, C.; Sharma, N.; Amarasinghe, G. K.; Caruso, A.; Caccuri, F.; Zani, A.; Novelli, G.; Sidhu, S. S.
10.1101/2021.11.02.466984 — bioengineering — Posted on 2021-11-04
3300 Complete genome sequence and Benzophenone-3 mineralisation potential of Rhodococcus sp. USK10, a bacterium isolated from riverbank sediment.
Martin, J. D.; Kruger, U. S.; Zervas, A.; Schostag, M. D.; Nielsen, T. K.; Aamand, J.; Hansen, L. H.; Ellegaard-Jensen, L.
10.1101/2021.11.04.467327 — genomics — Posted on 2021-11-04
3301 How low can you go: sex identification from sequencing data of species lacking assembled sex chromosomes
Cabrera, A. A.; Rey-Iglesia, A.; Louis, M.; Skovrind, M.; Westbury, M. V.; Lorenzen, E. D.
10.1101/2021.11.04.467120 — genomics — Posted on 2021-11-04
3303 Parental environmental effects are common and strong, but unpredictable, in Arabidopsis thaliana
Latzel, V.; Fischer, M.; Groot, M.; Gutzat, R.; Lampei, C.; Ouborg, J.; Parepa, M.; Schmid, K. J.; Vergeer, P.; Zhang, Y.; Bossdorf, O.
10.1101/2021.11.04.467350 — ecology — Posted on 2021-11-04
3305 Microthrombocytopenia caused by impaired microtubule stability in RhoB-deficient mice
Englert, M.; Aurbach, K.; Gerber, A.; Heib, T.; Becker, I. C.; Wackerbarth, L. M.; Kusch, C.; Baig, A. A.; Duetting, S.; Knaus, U. G.; Stigloher, C.; Nieswandt, B.; Pleines, I.; Nagy, Z.
10.1101/2021.11.04.467272 — cell biology — Posted on 2021-11-04
3308 HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures
Fardoos, R.; Nyquist, S. K.; Asowata, O. E.; Kazer, S. W.; Singh, A.; Ngoepe, A. N.; Giandhari, J. G.; Mthabela, N. M.; Ramjit, D.; Singh, S.; Karim, F.; Buus, S.; Anderson, F.; Porterfield, J. Z.; Sibiya, A. L.; Bipath, R.; Moodley, K.; Kuhn, W.; Berger, B.; Nguyen, S.; Oliveira, T. d.; Ndung'u, T.; Goulder, P.; Shalek, A. K.; Leslie, A.; Kloverpris, H. N.
10.1101/2021.11.04.467061 — immunology — Posted on 2021-11-04
3311 Glioma synapses recruit mechanisms of adaptive plasticity
Taylor, K. R.; Barron, T.; Zhang, H.; Hui, A. C.; Hartmann, G. G.; Ni, L.; Venkatesh, H. S.; Du, P.; Mancusi, R.; Yalcin, B.; Chau, I. J.; Ponnuswami, A.; Aziz-Bose, R.; Monje, M.
10.1101/2021.11.04.467325 — neuroscience — Posted on 2021-11-04
3312 3D reconstruction of cell nuclei in a full Drosophila brain
Mu, S.; Yu, S.-c.; Turner, N. L.; McKellar, C. E.; Dorkenwald, S.; Collman, F.; Koolman, S.; Moore, M.; Morejohn, S.; Silverman, B.; Willie, K.; Willie, R.; Bland, D.; Burke, A.; Ashwood, Z.; Luther, K.; Castro, M.; Ogedengbe, O.; Silversmith, W.; Wu, J.; Halageri, A.; Macrina, T.; Kemnitz, N.; Murthy, M.; Seung, H. S.
10.1101/2021.11.04.467197 — neuroscience — Posted on 2021-11-04
3315 Repeats Mimic Immunostimulatory Viral Features Across a Vast Evolutionary Landscape
Sulc, P.; Solovyov, A.; Marhon, S. A.; Sun, S.; LaCava, J. A.; Abdel-Wahab, O. I.; Vabret, N.; De Carvalho, D.; Monasson, R.; Cocco, S.; Greenbaum, B. D.
10.1101/2021.11.04.467016 — systems biology — Posted on 2021-11-04
3316 Expression of coffee florigen CaFT1 reveals a sustained floral induction window associated with asynchronous flowering in tropical perennials
Cardon, C. H.; Ricon de Oliveira, R.; Lesy, V.; Cherubino Ribeiro, T. H.; Peloso Pereira, L.; Fust, C.; Colasanti, J.; Chalfun-Junior, A.
10.1101/2021.11.04.466514 — plant biology — Posted on 2021-11-04
3318 Plant-derived insulator-like sequences for control of transgene expression
Park, J. Y.; Kovar, L.; LaFayette, P. R.; Wallace, J.; Parrott, W. A.
10.1101/2021.11.04.467280 — plant biology — Posted on 2021-11-04
3323 Protein arginylation is regulated during SARS-CoV-2 infection
Macedo-da-Silva, J.; Rosa-Fernandes, L.; Gomes, V. d. M.; Santiago, V. F.; Molnar, C. M. S.; Barboza, B. R.; de Sousa, E. E.; Durigon, E. L.; Marinho, C. R. F.; Wrenger, C.; Marie, S. K. N.; Palmisano, G.
10.1101/2021.11.02.466971 — cell biology — Posted on 2021-11-04
3331 Proteomics of spatially identified tissues in whole organs
Bhatia, H. S.; Brunner, A.-D.; Rong, Z.; Mai, H.; Thielert, M.; Al-Maskari, R.; Paetzold, J. C.; Kofler, F.; Todorov, M. I.; Ali, M.; Molbay, M.; Kolabas, Z. I.; Kaltenecker, D.; Mueller, S.; Lichtenthaler, S. F.; Menze, B. H.; Theis, F. J.; Mann, M.; Erturk, A.
10.1101/2021.11.02.466753 — bioengineering — Posted on 2021-11-04
3335 Correlative microscopy reveals the nanoscale morphology of E. coli-derived supported lipid bilayers
Bali, K.; Mohamed, Z.; Pappa, A.-M.; Daniel, S.; Kaminski, C. F.; Owens, R.; Mela, I.
10.1101/2021.11.04.467316 — microbiology — Posted on 2021-11-04
3336 Long-term Pannexin 1 ablation promotes structural and functional modifications in hippocampal neurons through the regulation of actin cytoskeleton and Rho GTPases activity.
Flores-Munoz, C.; Garcia-Rojas, F.; Perez, M. A.; Santander, O.; Mery, E.; Lopez-Espindola, D.; Gonzalez-Jamett, A.; Martinez, A. D.; Fuenzalida, M.; Ardiles, A. O.
10.1101/2021.11.03.467134 — neuroscience — Posted on 2021-11-04
3337 Sex-Related Neurocircuitry Supporting Camouflaging in Adults with Autism: Female Protection Insights
Walsh, M.; Pagni, B.; Monahan, L.; Delaney, S.; Smith, C. J.; Baxter, L.; Braden, B. B.
10.1101/2021.11.03.466990 — neuroscience — Posted on 2021-11-04
3339 SPARC in cancer-associated fibroblasts is an independent poor prognostic factor in non-metastatic triple-negative breast cancer and exhibits pro-tumor activity
Alcaraz, L. B.; Mallavialle, A.; Mollevi, C.; Boissiere Michot, F.; Mansouri, H.; Simony Lafontaine, J.; Laurent Matha, V.; Chardes, T.; Jacot, W.; Turtoi, A.; Roger, P.; Guiu, S.; Liaudet Coopman, E.
10.1101/2021.11.03.467104 — cancer biology — Posted on 2021-11-04
3341 decoupleR: Ensemble of computational methods to infer biological activities from omics data
Badia-i-Mompel, P.; Velez, J.; Braunger, J.; Geiss, C.; Dimitrov, D.; Müller-Dott, S.; Taus, P.; Dugourd, A.; Holland, C. H.; Ramirez Flores, R. O.; Saez-Rodriguez, J.
10.1101/2021.11.04.467271 — bioinformatics — Posted on 2021-11-04
3342 Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score
Bocher, O.; Ludwig, T. E.; Marenne, G.; Deleuze, J.-F.; Suryakant, S.; Odeberg, J.; Morange, P.-E.; Tregouët, D.-A.; Perdry, H.; Genin, E.
10.1101/2021.11.04.467235 — genetics — Posted on 2021-11-04
3343 Multi-omics profiling of Earth's biomes reveals that microbial and metabolite composition are shaped by the environment
Shaffer, J. P.; Nothias, L.-F.; Thompson, L. R.; Jon, S. G.; Salido, R. A.; Couvillion, S. P.; Brejnrod, A. D.; Huang, S.; Lejzerowicz, F.; Lutz, H. L.; Zhu, Q.; Martino, C.; Morton, J. T.; Karthikeyan, S.; Nothias-Esposito, M.; Dührkop, K.; Böcker, S.; Kim, H.; Aksenov, A. A.; Bittremieux, W.; Minich, J. J.; Marotz, C.; Bryant, M. M.; Sanders, K.; Schwartz, T.; Humphrey, G.; Vasquez-Baeza, Y.; Tripathi, A.; Parida, L.; Carrieri, A. P.; Haiminen, N.; Beck, K. L.; Das, P.; Gonzalez, A.; McDonald, D.; Karst, S. M.; Albertsen, M.; Ackermann, G.; DeReus, J.; Thomas, T.; Petras, D.; Shade, A.; St
10.1101/2021.06.04.446988 — ecology — Posted on 2021-11-04
3347 CDK1 and PLK1 cooperate to regulate BICD2, dynein activation and recruitment to the nucleus as well as centrosome separation in G2/M
Gallisa-Sune, N.; Sanchez-Fernandez-de-Landa, P.; Zimmermann, F.; Serna, M.; Paz, J.; Regue, L.; Llorca, O.; Luders, J.; Roig, J.
10.1101/2021.11.04.467245 — cell biology — Posted on 2021-11-04
3349 A novel and highly divergent Canine Distemper Virus lineage causing distemper in ferrets in Australia
George, A. M.; Wille, M.; Wang, J.; Anderson, K.; Cohen, S.; Moselen, J.; Lee, L. Y. Y.; Suen, W. W.; Bingham, J.; Dalziel, A. E.; Hurt, A. C.; Williams, D. T.; Deng, Y.-M.; Barr, I. G.
10.1101/2021.11.03.467217 — microbiology — Posted on 2021-11-04
3350 Turnover of MCMV-expanded CD8+ T-cells is similar to that of memory phenotype T-cells and independent of the magnitude of the response
Baliu-Pique, M.; Drylewicz, J.; Zheng, X.; Borkner, L.; Swain, A. C.; Otto, S.; de Boer, R. J.; Tesselaar, K.; Cicin-Sain, L.; Borghans, J. A.
10.1101/2021.11.03.467089 — immunology — Posted on 2021-11-04
3351 Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity
Guet-McCreight, A.; Chameh, H. M.; Mahallati, S.; Wishart, M.; Tripathy, S. J.; Valiante, T. A.; Hay, E.
10.1101/2021.11.03.467014 — neuroscience — Posted on 2021-11-04
3355 System Environmental Metrics Collector for EM facilities
Alink, L. M.; Eng, E. T.; Gheorghita, R.; Rice, W.; Cheng, A.; Carragher, B.; Potter, C. S.
10.1101/2021.11.04.467268 — biophysics — Posted on 2021-11-04
3356 Applications of AlphaFold beyond Protein Structure Prediction
Zhang, Y.; Li, P.; PAN, F.; Liu, H.; Hong, P.; Liu, X.; Zhang, J.
10.1101/2021.11.03.467194 — bioinformatics — Posted on 2021-11-04
3358 Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
Eising, E.; Mirza-Schreiber, N.; de Zeeuw, E. L.; Wang, C. A.; Truong, D. T.; Allegrini, A. G.; Shapland, C. Y.; Zhu, G.; Wigg, K. G.; Gerritse, M.; Molz, B.; Alagoz, G.; Gialluisi, A.; Abbondanza, F.; Rimfeld, K.; Van Donkelaar, M. M.; Liao, Z.; Jansen, P. R.; Andlauer, T. F. M.; Bates, T. C.; Bernard, M.; Blokland, K.; Borglum, A. D.; Bourgeron, T.; Brandeis, D.; Ceroni, F.; Dale, P. S.; de Jong, P. F.; DeFries, J. C.; Demontis, D.; Feng, Y.; Gordon, S. D.; Guger, S. L.; Hayiou-Thomas, M. E.; Hernandez-Cabrera, J. A.; Hottenga, J.- J.; Hulme, C.; Kerr, E. N.; Koomar, T.; Landerl, K.; Lovett,
10.1101/2021.11.04.466897 — genomics — Posted on 2021-11-04
3361 MTG16 (CBFA2T3) represses E protein-dependent transcription to regulate colonic secretory cell differentiation, epithelial regeneration, and tumorigenesis
Brown, R. E.; Jacobse, J.; Anant, S. A.; Blunt, K. M.; Chen, B.; Vega, P. N.; Jones, C. T.; Pilat, J. M.; Revetta, F.; Gorby, A. H.; Stengel, K. R.; Choksi, Y. A.; Palin, K.; Piazuelo, M. B.; Washington, M. K.; Lau, K. S.; Goettel, J. A.; Hiebert, S. W.; Short, S. P.; Williams, C. S.
10.1101/2021.11.03.467178 — cell biology — Posted on 2021-11-04
3363 Amelioration of DSS-induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22
Kim, S.; Hong, E.-H.; Lee, C.-K.; Ryu, Y.; Jeong, H.; Heo, S.; Lee, J.-j.; Ko, H.-J.
10.1101/2021.11.04.467038 — immunology — Posted on 2021-11-04
3364 Thymic macrophages consist of two populations with distinct localization and origin
Zhou, T.-A.; Hsu, H.-P.; Tu, Y.-H.; Lin, C.-Y.; Chen, N.-J.; Tsai, J.-W.; Robey, E. A.; Huang, H.-C.; Hsu, C.-L.; Dzhagalov, I. L.
10.1101/2021.11.04.467238 — immunology — Posted on 2021-11-04
3366 Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric p-Phenylene Ethynylenes
Fanni, A. M.; Okoye, D.; Monge, F. A.; Hammond, J.; Maghsoodi, F.; Martin, T. D.; Brinkley, G.; Phipps, M. L.; Martinez, J. S.; Evans, D. G.; Whitten, D.; Chi, E. Y.
10.1101/2021.11.03.467121 — neuroscience — Posted on 2021-11-04
3369 Increasing the throughput of sensitive proteomics by plexDIA
Derks, J.; Leduc, A.; Huffman, R. G.; Specht, H.; Ralser, M.; Demichev, V.; Slavov, N.
10.1101/2021.11.03.467007 — systems biology — Posted on 2021-11-04
3370 Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells
Lensch, S.; Herschl, M. H.; Ludwig, C. H.; Sinha, J.; Hinks, M. M.; Mukund, A.; Fujimori, T.; Bintu, L.
10.1101/2021.11.04.467237 — synthetic biology — Posted on 2021-11-04
3371 Akaby - cell-free protein expression system for linear templates
Sato, W.; Sharon, J.; Deich, C.; Gaut, N.; Cash, B.; Engelhart, A. E.; Adamala, K. P.
10.1101/2021.11.03.467179 — synthetic biology — Posted on 2021-11-04
3373 PEPc-mediated CO2 assimilation provides carbons to gluconeogenesis and the TCA cycle in both dark-exposed and illuminated guard cells
Lima, V. F.; Medeiros, D. B.; Candido-Sobrinho, S. A.; Freire, F. B. S.; Porto, N. P.; Erban, A.; Kopka, J.; Schwarzlander, M.; Fernie, A.; Daloso, D. M.
10.1101/2021.11.03.467183 — plant biology — Posted on 2021-11-04
3374 Wheat photosystem II heat tolerance responds dynamically to short and long-term warming
Posch, B. C.; Hammer, J.; Atkin, O. K.; Bramley, H.; Ruan, Y.-L.; Trethowan, R.; Coast, O.
10.1101/2021.11.01.466822 — plant biology — Posted on 2021-11-04
3379 Detection of pseudouridine modifications and type I/II hypermodifications in human mRNAs using direct, long-read sequencing
Tavakoli, S.; Nabizadehmashhadtoroghi, M.; Makhamreh, A.; Gamper, H.; Rezapour, N.; Hou, Y.-M.; Wanunu, M.; Rouhanifard, S. H.
10.1101/2021.11.03.467190 — bioengineering — Posted on 2021-11-04
3380 Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders
Dieudonne, T.; Herrera, S. A.; Laursen, M. J.; Lejeune, M.; Stock, C.; Slimani, K.; Jaxel, C.; Lyons, J. A.; Montigny, C.; Pomorski, T. G.; Nissen, P.; Lenoir, G.
10.1101/2021.11.03.467174 — biochemistry — Posted on 2021-11-04
3381 Recombination landscape dimorphism contributes to sexchromosome evolution in the dioecious plant Rumexhastatulus
Rifkin, J. L.; Hnatovzka, S.; Yuan, M.; Sacchi, B. M.; Choudhury, B. I.; Gong, Y.; Rastas, P.; Barrett, S. C. H.; Wright, S. I.
10.1101/2021.11.03.466946 — genetics — Posted on 2021-11-04
3385 Maternally-inherited anti-sense piRNAs antagonize transposon expression in teleost embryos
Guo, Y.; Gert, K. R.; Lebedeva, S.; Potok, M. E.; Wike, C. L.; Grow, E. J.; Ketting, R. F.; Pauli, A.; Cairns, B.
10.1101/2021.11.03.467172 — developmental biology — Posted on 2021-11-04
3388 Intracellular development and impact of a eukaryotic parasite on its zombified microalgal host in the marine plankton
Decelle, J.; Kayal, E.; Bigeard, E.; Gallet, B.; Bougoure, J.; Clode, P.; Schieber, N.; Templin, R.; Hegenberger, E.; Prensier, G.; Chevalier, F.; Schwab, Y.; Guillou, L.
10.1101/2021.11.04.467241 — cell biology — Posted on 2021-11-04
3389 PTBP1/HNRNP I controls intestinal epithelial cell regeneration by maintaining stem cell survival and stemness
Tung, W.; Chembazhi, U. V.; Yang, J.; Nguyen, K. L.; Lalwani, A.; Bangru, S.; Yee, D.; Chin, K.; Kalsotra, A.; Mei, W.
10.1101/2021.11.03.466345 — molecular biology — Posted on 2021-11-04
3390 Distinct roles for CDK-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction
Dimitrova, E.; Feldmann, A.; van der Weide, R. H.; Flach, K. D.; Lastuvkova, A.; de Wit, E.; Klose, R. J.
10.1101/2021.11.04.467119 — molecular biology — Posted on 2021-11-04
3393 miR-409-3p represses Cited2 at the evolutionary emergence of the callosal and corticospinal projections
Wagner, N. R.; Sinha, A.; Siththanandan, V. B.; Kowalchuk, A. N.; MacDonald, J.; Tharin, S.
10.1101/2021.11.03.467191 — neuroscience — Posted on 2021-11-04
3394 Chemical inhibition of pathological reactive astrocytes promotes neural protection
Clayton, B. L. L.; Kristell, J. D.; Allan, K. C.; Karl, M.; Garrison, E.; Maeno-Hikichi, Y.; Sturno, A.; Shick, E.; Miller, R. H.; Tesar, P. J.
10.1101/2021.11.03.467083 — neuroscience — Posted on 2021-11-04
3395 Intact Drosophila Whole Brain Cellular Quantitation reveals Sexual Dimorphism
Jiao, W.; Spreemann, G.; Ruchti, E.; Banerjee, S.; Shi, Y.; Stowers, R. S.; Hess, K.; McCabe, B. D.
10.1101/2021.11.03.467146 — neuroscience — Posted on 2021-11-04
3397 Wnt1-Cre mediated deletion of BMP7 suggests a role for neural crest-derived BMP7 in retina development and function
Kung, T. F.; Baddam, P.; Liu, R.; Maripuri, D. P.; Dimopoulos, I. S.; MacDonald, I. M.; Sauve, Y.; Graf, D.
10.1101/2021.11.03.466838 — physiology — Posted on 2021-11-04
3401 Towards prevention of re-entrant arrhythmias: Injectable hydrogel electrodes enable direct capture of previously inaccessible cardiac tissues
Rodriguez-Rivera, G.; Post, A.; John, M.; Buchan, S.; Wancura, M.; Chwatko, M.; Waldron, C.; Kalkunte, N.; Zoldan, J.; Arseneault, M.; Razavi, M.; Cosgriff-Hernandez, E.
10.1101/2021.11.03.467102 — bioengineering — Posted on 2021-11-04
3402 SVJAM: Joint Analysis of Structural Variants Using Linked Read Sequencing Data
Gunturkun, M. H.; Villani, F.; Colonna, V.; Ashbrook, D.; Williams, R. W.; Chen, H.
10.1101/2021.11.02.467006 — genomics — Posted on 2021-11-04
3403 High-Plex Multiomic Analysis in FFPE Tissue at Single-Cellular and Subcellular Resolution by Spatial Molecular Imaging
He, S.; Bhatt, R.; Birditt, B.; Brown, C.; Brown, E.; Chantranuvatana, K.; Danaher, P.; Dunaway, D.; Filanoski, B.; Garrison, R. G.; Geiss, G.; Gregory, M. T.; Hoang, M. L.; Killingbeck, E. E.; Kim, T. K.; Kim, Y.; Korukonda, M.; Kutchma, A.; Lee, E.; Lewis, Z. R.; Liang, Y.; Nelson, J. S.; Ong, G.; Perillo, E.; Phan, J.; Phan-Everson, T.; Piazza, E.; Rane, T.; Reitz, Z.; Rhodes, M.; Rosenbloom, A.; Ross, D.; SATO, H.; Wardhani, A. W.; Williams-Wietzikoski, C.; Wu, L.; Beechem, J. M.
10.1101/2021.11.03.467020 — genomics — Posted on 2021-11-04
3404 Blueprint for Phasing and Assembling the Genomes of Heterozygous Polyploids: Application to the Octoploid Genome of Strawberry
Hardigan, M. A.; Feldmann, M. J.; Pincot, D. D.; Famula, R. A.; Vachev, M. V.; Madera, M. A.; Zerbe, P. J.; Mars, K.; Peluso, P.; Rank, D.; Ou, S.; Saski, C. A.; Acharya, C. B.; Cole, G. S.; Yocca, A. E.; Platts, A. E.; Edger, P. P.; Knapp, S. J.
10.1101/2021.11.03.467115 — genomics — Posted on 2021-11-04
3405 Two-speed genome expansion drives the evolution of pathogenicity in animal fungal pathogens
Wacker, T.; Helmstetter, N.; Wilson, D.; Fisher, M. C.; Studholme, D. J.; Farrer, R. A.
10.1101/2021.11.03.467166 — genomics — Posted on 2021-11-04
3411 Selecting species for restoration in foundational assemblages
Madin, J.; McWilliam, M.; Quigley, K.; Bay, L.; Bellwood, D.; Bridge, T.; Doropoulos, C.; Fernandes, L.; Harrison, P.; Hoey, A.; Mumby, P.; Richards, Z.; Riginos, C.; Suggett, D.; van Oppen, O.
10.1101/2021.11.03.467181 — ecology — Posted on 2021-11-04
3416 Cone-driven retinal responses are shaped by rod but not cone HCN1
Lankford, C.; Umino, Y.; Poria, D.; Kefalov, V.; Solessio, E.; Baker, S. A.
10.1101/2021.11.03.467151 — neuroscience — Posted on 2021-11-04
3417 Transcription factor control of dendrite targeting via combinatorial cell-surface codes
Xie, Q.; Li, J.; Li, H.; Udeshi, N. D.; Svinkina, T.; Kohani, S.; Guajardo, R.; Mani, D. R.; Xu, C.; Li, T.; Han, S.; Wei, W.; Shuster, S. A.; Luginbuhl, D. J.; Ting, A. Y.; Carr, S. A.; Luo, L.
10.1101/2021.11.03.467130 — neuroscience — Posted on 2021-11-04
3420 Systematic Review of Aptamer Sequence Reporting in the Literature Reveals Widespread Unexplained Sequence Alterations
Miller, A. A.; Rao, A. S.; Nelakanti, S. R.; Kujalowicz, C.; Shi, T.; Rodriguez, T.; Ellington, A.; Stovall, G. M.
10.1101/2021.11.02.466945 — synthetic biology — Posted on 2021-11-04
3423 Endothelial Rap1B mediates T-cell exclusion to promote tumor growth -a novel mechanism underlying vascular immunosuppression
Sharma, G. P.; Kosuru, R.; Lakshmikanthan, S.; Zheng, S.; Chen, Y.; Burns, R.; Xin, G.; Cui, W.; Chrzanowska, M.
10.1101/2021.11.03.467057 — cancer biology — Posted on 2021-11-04
3429 An intrinsic temporal order of c-Jun N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment
Waudby, C. A.; Alvarez-Teijeiro, S.; Suppinger, S.; Brown, P. R.; Behrens, A.; Christodoulou, J.; Mylona, A.
10.1101/2021.11.03.465096 — biochemistry — Posted on 2021-11-04
3431 Novel insights into the cold resistance of Hevea brasiliensis through coexpression networks
Silva, C. C.; Bajay, S. K.; Aono, A. H.; Francisco, F. R.; Junior, R. B.; de Souza, A. P.; Mantello, C. C.; Vicentini dos Santos, R.
10.1101/2021.11.02.466997 — genomics — Posted on 2021-11-04
3433 Effects of chlorpyrifos on early development and anti-predator behavior of agile frogs
Miko, Z.; Bokony, V.; Ujhegyi, N.; Nemeshazi, E.; Erös, R.; Orf, S.; Hettyey, A.
10.1101/2021.11.03.467073 — ecology — Posted on 2021-11-04
3435 Missing interactions: the current state of multispecies connectivity analysis
Wood, S. L. R.; Martins, K. T.; Dumais-Lalonde, V.; Tanguy, O.; Maure, F.; St. Denis, A.; Rayfield, B.; Martin, A. E.; Gonzalez, A.
10.1101/2021.11.03.466769 — ecology — Posted on 2021-11-04
3437 Automatic Detection and Neurotransmitter Prediction of Synapses in Electron Microscopy
Zhang, A.; Shailja, S.; Borba, C.; Miao, Y.; Goebel, M.; Ruschel, R.; Ryan, K.; Smith, W.; Manjunath, B. S.
10.1101/2021.11.02.467022 — neuroscience — Posted on 2021-11-04
3438 Visual category representations in the infant brain
Xie, S.; Hoehl, S.; Moeskops, M.; Kayhan, E.; Kliesch, C.; Turtleton, B.; Koester, M.; Cichy, R. M.
10.1101/2021.11.03.466293 — neuroscience — Posted on 2021-11-04
3439 Anatomically-based skeleton kinetics and pose estimation in freely-moving rodents
Monsees, A.; Voit, K.-M.; Wallace, D. J.; Sawinski, J.; Leks, E.; Scheffler, K.; Macke, J. H.; Kerr, J. N.
10.1101/2021.11.03.466906 — neuroscience — Posted on 2021-11-04
3441 A high-fat diet changes astrocytic metabolism to enhance synaptic plasticity and promote exploratory behavior
Popov, A.; Brazhe, N.; Fedotova, A.; Tiaglik, A.; Bychkov, M.; Morozova, K.; Brazhe, A.; Aronov, D.; Lyukmanova, E.; Lazareva, N.; Li, L.; Verkhratsky, A.; Semyanov, A.
10.1101/2021.11.03.467141 — neuroscience — Posted on 2021-11-04
3443 Dopamine mediates the bidirectional update of interval timing
Jakob, A. M. V.; Mikhael, J. G.; Hamilos, A. E.; Assad, J. A.; Gershman, S. J.
10.1101/2021.11.02.466803 — neuroscience — Posted on 2021-11-04
3444 Drug specific transcriptomic signatures in healthy human subject iPSC derived cardiomyocytes
Hansen, J.; Xiong, Y.; Dhanan, P.; Hu, B.; Jayaraman, G.; Tolentino, R.; Chen, Y.; Beaumont, K. G.; Sebra, R.; Vidovic, D.; Schuerer, S. C.; Goldfarb, J.; Gallo, J.; Birtwistle, M. R.; Sobie, E. R.; Azeloglue, E. U.; Schaniel, C.; Dubois, N. C.; Iyengar, R.
10.1101/2021.11.02.466774 — systems biology — Posted on 2021-11-04
3446 Epithelial-mesenchymal transition is the main driver of intrinsic metabolism in cancer cell lines
Cherkaoui, S.; Durot, S.; Bradley, J.; Critchlow, S.; Dubuis, S.; Masiero, M. M.; Wegmann, R.; Snijder, B.; Othman, A.; Bendtsen, C.; Zamboni, N.
10.1101/2021.11.02.466992 — systems biology — Posted on 2021-11-04
3447 Wound-like tumor periphery in human breast cancer predicts a convergent drug nonresponse
Li, L.; Liao, X.; Fu, F.; Xi, G.; Kang, D.; He, J.; Guo, W.; Qiu, L.; Han, Z.; Wang, X.; Zhan, Q.; You, S.; Chen, J.; Wang, C.; Boppart, S. A.; Tu, H.
10.1101/2021.11.02.467008 — pathology — Posted on 2021-11-04
3448 Conjugation of palbociclib with MHI-148 has an increased cytotoxic effect for breast cancer cells and an altered mechanism of action
Leung, E.; Tomek, P.; Tercel, M.; Reynisson, J.; Park, T. I. H.; Cooper, E.; Denny, W. A.; Choi, P. J.; Jose, J.
10.1101/2021.11.02.466693 — cancer biology — Posted on 2021-11-04
3449 The cytosolic role of EZH2-IMPDH2 complex in melanoma progression and metastasis via GTP regulation
Kuser Abali, G.; Noguchi, F.; Szeto, P.; Zhang, Y.; Huang, C.; Barlow, C. K.; Pomilio, G.; Chew, C.; Masoumi Moghaddam, S.; Zhao, P.; Andrews, M.; Leece, I.; Cheung, J. G.; Ameratunga, M.; Wong, N. C.; Schittenhelm, R. B.; Wei, A.; Shackleton, M.
10.1101/2021.11.02.467024 — cancer biology — Posted on 2021-11-04
3455 Machine learning-based library design improves packaging and diversity of adeno-associated virus (AAV) libraries
ZHU, D.; Brookes, D. H.; Busia, A.; Carneiro, A.; Fannjiang, C.; Popova, G.; Shin, D.; Chang, E. F.; Nowakowski, T. J.; Listgarten, J.; Schaffer, D. V.
10.1101/2021.11.02.467003 — bioengineering — Posted on 2021-11-04
3456 Laser-driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors
MISSEY, F.; DONAHUE, M. J.; WEBER, P.; NGOM, I.; ACERBO, E.; BOTZANOWSKI, B.; MIGLIACCIO, L.; Jirsa, V.; GLOWACKI, E. D.; Williamson, A.
10.1101/2021.11.02.466993 — bioengineering — Posted on 2021-11-04
3457 Biofabrication of development-inspired scaffolds for regeneration of the annulus fibrosus macro- and microarchitecture
Kluser, N.; Sprecher, C.; Alig, G. U.; Haeckel, S.; Albers, C. E.; Alini, M.; Grad, S.; Eglin, D.; Vernengo, A. J.
10.1101/2021.11.03.467069 — bioengineering — Posted on 2021-11-04
3458 Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein
Kampmeyer, C.; Larsen-Ledet, S.; Wagnkilde, M. R.; Michelsen, M.; Iversen, H. K. M.; Nielsen, S. V.; Lindemose, S.; Caregnato, A.; Ravid, T.; Stein, A.; Teilum, K.; Lindorff-Larsen, K.; Hartmann-Petersen, R.
10.1101/2021.11.04.467226 — biochemistry — Posted on 2021-11-04
3459 Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer
Yang, Z.; Dam, K.-M. A.; Bridges, M. D.; Hoffmann, M. A. G.; DeLaitsch, A. T.; Gristick, H. B.; Escolano, A.; Gautam, R.; Martin, M. A.; Nussenzweig, M.; Hubbell, W.; Bjorkman, P. J.
10.1101/2021.11.02.466200 — immunology — Posted on 2021-11-04
3461 Plasticity in Ligand Recognition at Somatostatin Receptors
Robertson, M. J.; Meyerowitz, J. G.; Panova, O.; Borrelli, K.; Skiniotis, G.
10.1101/2021.11.02.466988 — biophysics — Posted on 2021-11-04
3462 Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease
Fan, Y.; Sun, Y.; Yu, W.; Tao, Y.; Xia, W.; Liu, Y.; Tang, Y.; Sun, Y.; Liu, F.; Cao, Q.; Wu, J.; Liu, C.; Wang, J.; Li, D.
10.1101/2021.11.02.467019 — biophysics — Posted on 2021-11-04
3464 Exploration and analysis of R-loop mapping data with RLBase
Miller, H.; Montemayor, D.; Li, J.; Levy, S.; Sharma, K.; Frost, B.; Chedin, F.; Bishop, A. J.
10.1101/2021.11.01.466854 — bioinformatics — Posted on 2021-11-04
3467 Multiple hybridization events punctuate the evolutionary trajectory of Malassezia furfur
Theelen, B.; Mixao, V.; Ianiri, G.; Goh, J. P. Z.; Dijksterhuis, J.; Heitman, J.; Dawson, T. L.; Gabaldon, T.; Boekhout, T.
10.1101/2021.11.02.466935 — evolutionary biology — Posted on 2021-11-04
3469 Fungal biodiversity in Arctic paleoecosystems assessed by metabarcoding of lake sedimentary ancient DNA
Seeber, P. A.; von Hippel, B.; Kauserud, H.; Loeber, U.; Stoof-Leichsenring, K.; Herzschuh, U.; Epp, L.
10.1101/2021.11.02.462738 — ecology — Posted on 2021-11-04
3470 Sex and Circuit Specific Dopamine Transporter Regulation Underlies Unique Behavioral Trajectories of Functional SLC6A3 Coding Variation
Stewart, A.; Mayer, F. P.; Gowrishankar, R.; Davis, G. L.; Areal, L. B.; Gresch, P. J.; Katamish, R. M.; Peart, R.; Stilley, S. E.; Spiess, K.; Rabil, M. J.; Diljohn, F. A.; Wiggins, A. E.; Vaughan, R. A.; Hahn, M. K.; Blakely, R. D.
10.1101/2021.11.02.466932 — neuroscience — Posted on 2021-11-04
3472 Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury
Sanghvi, S.; Szteyn, K.; Ponnalagu, D.; Sridharan, D.; Lam, A.; Hansra, I.; Chaudhury, A.; Majumdar, U.; Kohut, A.; Gururaja Rao, S.; Khan, M.; Garg, V.; Singh, H.
10.1101/2021.11.02.466585 — physiology — Posted on 2021-11-04
3473 Building tools for machine learning and artificial intelligence in cancer research: best practices and a case study with the PathML toolkit for computational pathology
Rosenthal, J.; Carelli, R.; Omar, M.; Brundage, D.; Ella, H.; Nyman, J.; Hari, S.; Van Allen, E. M.; Luigi, M.; Umeton, R.; Loda, M.
10.1101/2021.10.21.465212 — cancer biology — Posted on 2021-11-04
3480 Bacterial colonisation dynamics of household plastics in a coastal environment
Lear, L.; Padfield, D.; Dowsett, T.; Jones, M.; Kay, S.; Hayward, A.; Vos, M.
10.1101/2021.11.02.466905 — ecology — Posted on 2021-11-04
3483 Biological Factors and Self-Perception of Stress Predict Human Freeze-Like Responses in the Context of Self-Defence Training and Personal Experience with Violence
Lenart, P.; Vit, M.; Mareckova, K.; Novak, J.; Zlamal, F.; Mikl, M.; Reguli, Z.; Bugala, M.; Cihounkova, J.; Precechtel, P.; Malcik, V.; Vojtisek, T.; Kucera, J.; Kucerova, J. F.; Hajnova, V.; Tomandlova, M.; Sip, R.; Rackova, L.; Grulichova, M.; Tomandl, J.; Brazdil, M.; Bienertova-Vasku, J.
10.1101/2021.11.02.466879 — neuroscience — Posted on 2021-11-04
3486 Retinal OFF ganglion cells allow detection of quantal shadows at starlight
Westö, J.; Martyniuk, N.; Koskela, S.; Turunen, T.; Pentikäinen, S.; Ala-Laurila, P.
10.1101/2021.11.02.466884 — neuroscience — Posted on 2021-11-04
3487 Violet light modulates the central nervous system to regulate memory and mood
Sasaki, N.; Gusain, P.; Hayano, M.; Sugaya, T.; Tonegawa, N.; Hatanaka, Y.; Tamura, R.; Okuyama, K.; Osada, H.; Ban, N.; Mitsukura, Y.; Lang, R. A.; Mimura, M.; Tsubota, K.
10.1101/2021.11.02.466604 — neuroscience — Posted on 2021-11-04
3488 Age-dependent Effect Imposed by Rotenone Exposure
Moseley, M. C.; Rawls, A.; Sponsel, V. M.; Berger, M. S.; Abate, A. R.; LIN, C. H. A.
10.1101/2021.11.01.466812 — neuroscience — Posted on 2021-11-04
3490 Towards a general framework for modeling large-scale biophysical neuronal networks: a full-scale computational model of the rat dentate gyrus
Raikov, I. G.; Milstein, A. D.; Moolchand, P.; Szabo, G. G.; Schneider, C. J.; Hadjiabadi, D. H.; Chatzikalymniou, A. P.; Soltesz, I.
10.1101/2021.11.02.466940 — neuroscience — Posted on 2021-11-04
3491 Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons
Ho, T. S.-Y.; Hees, J. T.; Xu, Z.; Kawaguchi, R.; Biscola, N. P.; Taub, D. G.; Chen, K.; Chen, X.; Barrett, L. B.; Cheng, L.; Gabel, C. V.; Havton, L. A.; Geschwind, D. H.; Woolf, C. J.
10.1101/2021.11.02.466937 — neuroscience — Posted on 2021-11-04
3493 Comprehensive RNA-Seq Reveals Molecular Changes in Kidney Malignancy Among People Living with HIV
BAO, J.; Ye, J.; Xu, J.; Liu, S.; Wang, L.; Li, Z.; Li, Q.; Liu, F.; He, X.; Zou, H.; Feng, Y.; Corpe, C.; Zhang, X.; Xu, J.; Zhu, T.; Wang, J.
10.1101/2021.11.02.466880 — cancer biology — Posted on 2021-11-04
3494 Intratumoral Delivered Novel Circular mRNA Encoding Cytokines for Immune Modulation and Cancer Therapy
Yang, J.; Zhu, J.; Chen, Y.; Du, Y.; Tan, Y.; Wu, L.; Sun, J.; Zhai, M.; Wei, L.; Li, N.; Huang, K.; Hou, Q.; Tong, Z.; Bechthold, A.; Sun, Z.; Zuo, C.
10.1101/2021.11.01.466725 — cancer biology — Posted on 2021-11-04
3495 Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
Harpaz, N.; Mittelman, T.; Beresh, O.; Salame, T. M.; Furth, N.; Ron, G.; Shema, E.
10.1101/2021.11.02.466907 — cancer biology — Posted on 2021-11-04
3496 A lineage-specific epigenetic memory of inflammation potentiates Kras-driven pancreatic tumorigenesis
Falvo, D. J.; Grimont, A.; Zumbo, P.; Yang, J. L.; Osterhoudt, A.; Breves, S. L.; Pan, G.; Rendeiro, A. F.; Wilkinson, J. E.; Dündar, F.; Elemento, O.; Yantiss, R. K.; Betel, D.; Koche, R.; Chandwani, R.
10.1101/2021.11.01.466807 — cancer biology — Posted on 2021-11-04
3497 DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma
Martin, J. C.; Gupta, A.; Hagoel, T. J.; Gao, L.; Lynch, M. L.; Woloszynska, A.; Melendy, T.; Kane, J.; Kuechle, J.; Ohm, J.
10.1101/2021.11.02.466939 — cancer biology — Posted on 2021-11-04
3503 Coiled Coil Crosslinked Alginate Hydrogels Dampen Macrophage-Driven Inflammation
Clapacs, Z.; O'Neill, C. L.; Shrimali, P.; Lokhande, G.; Files, M.; Kim, D. D.; Gaharwar, A.; Rudra, J. S.
10.1101/2021.11.01.466776 — bioengineering — Posted on 2021-11-04
3506 Prioritising Autoimmunity Risk Variants for Functional Analyses by Fine-Mapping Mutations Under Natural Selection
Pankratov, V.; Yunusbaeva, M.; Ryakhovsky, S.; Zarodniuk, M.; Estonian Biobank Research Team, ; Yunusbayev, B.
10.1101/2021.11.01.466789 — genetics — Posted on 2021-11-04
3508 A phosphoinositide and RAB switch controls early macropinocytosis
Spangenberg, H.; Sneeggen, M.; Mateo Tortola, M.; Valenzuela-Montenegro, C.; Chang, Y.-Y.; Stenmark, H.; Raiborg, C.; Schink, K. O.
10.1101/2021.11.03.467145 — cell biology — Posted on 2021-11-04
3509 Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival
Okuda, K.; Franco, M. C.; Yasunaga, A.; Gazzinelli, R.; Rabinovitch, M.; Cherry, S.; Silverman, N.
10.1101/2021.11.03.467107 — cell biology — Posted on 2021-11-04
3510 Low selectivity index of ivermectin and macrocyclic lactones on SARS-CoV2 replication in vitro argues against their therapeutic use for COVID-19.
Chable-Bessia, C.; Boulle, C.; Neyret, A.; Swain, J. M.; Henaut, M.; Merida, P.; Gros, N.; Makinson, A.; Lyonnais, S.; Chesnais, C. B.; Muriaux, D.
10.1101/2021.11.01.466865 — microbiology — Posted on 2021-11-04
3511 Proteomic and single-cell transcriptomic dissection of human plasmacytoid dendritic cell response to influenza virus
Ghanem, M. H.; Shih, A. J.; Khalili, H.; Werth, E.; Chakrabarty, J. K.; Brown, L. M.; Simpfendorfer, K. R.; Gregersen, P. K.
10.1101/2021.11.01.466839 — immunology — Posted on 2021-11-04
3512 Caste, sex, and parasitism influence brain plasticity in a social wasp
Gandia, K. M.; Cappa, F.; Baracchi, D.; Hauber, M. E.; Beani, L.; Uy, F. M. K.
10.1101/2021.11.01.466692 — neuroscience — Posted on 2021-11-04
3513 Simulated attack reveals how lesions affect network properties in post-stroke aphasia
Medaglia, J. D.; Erickson, B.; Pustina, D.; Kelkar, A.; DeMarco, A.; Dickens, J. V.; Turkeltaub, P. E.
10.1101/2021.11.01.466833 — neuroscience — Posted on 2021-11-04
3517 Time-of-day influences on skill acquisition and consolidation after physical and mental practices
TRUONG, C.; HILT, P. M.; BOUGUILA, F.; BOVE, M.; LEBON, F.; PAPAXANTHIS, C.; RUFFINO, C.
10.1101/2021.11.02.466949 — neuroscience — Posted on 2021-11-04
3518 Learning from ingroup experiences changes intergroup impressions
Zhou, Y.; Lindström, B.; Soutschek, A.; Kang, P.; Tobler, P. N.; Hein, G.
10.1101/2021.11.02.466926 — neuroscience — Posted on 2021-11-04
3520 LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001
Martin Vazquez, E.; Cobo_Vuilleumier, N.; Araujo Legido, R.; Nola, E.; Lopez Bermudo, L.; Crespo, A.; Romero-Zerbo, S. Y.; Garcia-Fernandez, M.; Martin Montalvo, A.; Rojas, A.; Ferrer, J.; Comaills, V.; Bermudez-Silva, F. J.; Gannon, M.; Martin, F.; Lorenzo, P. I.; Gauthier, B. R.
10.1101/2021.11.02.466895 — physiology — Posted on 2021-11-04
3521 Unbiased Proteomics, Histochemistry, and Mitochondrial DNA Copy Number Reveal Better Mitochondrial Health in Muscle of High Functioning Octogenarians
Hepple, R.; Ubaida-Mohien, C.; Spendiff, S.; Lyashkov, A.; Moaddel, R.; MacMillan, N.; Filion, M.-E.; Morais, J.; Taivassalo, T.; Ferrucci, L.
10.1101/2021.11.02.466912 — physiology — Posted on 2021-11-04
3522 Elexacaftor/Tezacaftor/Ivacaftor alters branching morphogenesis of the mouse embryonic lung
Lhuillier, M.; Aoust, L.; Dreano, E.; Franco-Montoya, M.-L.; Landry-Truchon, K.; Houde, N.; Chhun, S.; Hinzpeter, A.; Edelman, A.; Delacourt, C.; Jeannotte, L.; Sermet-Gaudelus, I.; Hadchouel Duverge, A.
10.1101/2021.11.01.466814 — pharmacology and toxicology — Posted on 2021-11-04
3523 Cross-linkers at growing microtubule ends generate forces that drive actin transport
Alkemade, C.; Wierenga, H.; Volkov, V. A.; Preciado Lopez, M.; Akhmanova, A.; ten Wolde, P. R.; Dogterom, M.; Koenderink, G. H.
10.1101/2021.07.09.451744 — biophysics — Posted on 2021-11-04
3525 Quality-controlled R-loop meta-analysis reveals the characteristics of R-Loop consensus regions
Miller, H.; Montemayor, D.; Abdul, J.; Vines, A.; Levy, S.; Sharma, K.; Frost, B.; Chedin, F.; Bishop, A. J.
10.1101/2021.11.01.466823 — bioinformatics — Posted on 2021-11-04
3526 A novel hybrid protein promotes Aβ clearance and reduces inflammatory response through MerTK
Caberoy, N. B.; Samentar, L. P.; Salazar, A.; Pan, P.; Etebar, K.; Choy, K.; Uddin, D.; Eliseeff, P.; Bugayong, A. M.; Garrido, J. A.; Emini, A.; Rock, N.
10.1101/2021.11.03.467048 — molecular biology — Posted on 2021-11-04
3530 Discrimination of species within the Enterobacter cloacae complex using MALDI-TOF Mass Spectrometry and Fourier-Transform Infrared Spectroscopy coupled with Machine Learning tools
Candela, A.; Mateos, M.; Gomez Asenjo, A.; Arroyo, M. J.; Hernandez-Garcia, M.; del Campo, R.; Cercenado, E.; Mendez, G.; Mancera, L.; Caballero, J. d. D.; Martinez-Garcia, L.; Gijon, D.; Morosini, M. I.; Ruiz-Garbajosa, P.; Canton, R.; Munoz, P.; Rodriguez-Temporal, D.; Rodriguez-Sanchez, B.
10.1101/2021.11.02.467040 — microbiology — Posted on 2021-11-04
3531 Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function
Popovic, B.; Guislain, A.; Engels, S.; Nicolet, B. P.; Jurgens, A. P.; Paravinja, N.; Freen-van Heeren, J. J.; van Alphen, F. P.; van den Biggelaar, M.; Salerno, F.; Wolkers, M. C.
10.1101/2021.11.03.467112 — immunology — Posted on 2021-11-04
3532 A viral toolbox for conditional and transneuronal gene expression in zebrafish
Satou, C.; Neve, R. L.; Oyibo, H. K.; Zmarz, P.; Huang, K.-H.; Arn Bouldoires, E.; Mori, T.; Higashijima, S.-i.; Keller, G. B.; Friedrich, R. W.
10.1101/2021.03.25.436574 — neuroscience — Posted on 2021-11-04
3534 Pre-clinical validation of an RNA-based precision oncology platform for patient-therapy alignment in a diverse set of human malignancies resistant to standard treatments
Mundi, P. S.; Dela Cruz, F. S.; Grunn, A.; Diolaiti, D.; Mauguen, A.; Rainey, A. R.; Guillan, K. C.; Siddiquee, A.; You, D.; Realubit, R.; Karan, C.; Ortiz, M. V.; Accordino, M.; Mistretta, S.; Brogan, F.; Bruce, J. N.; Caescu, C. I.; Carvajal, R.; Crew, K.; Decastro, G.; Heaney, M.; Henick, B.; Hershman, D.; Hou, J.; Iwamoto, F.; Jurcic, J.; Kiran, R. P.; Kluger, M.; Kreisl, T.; Lamanna, N.; Lassman, A.; Lim, E.; Manji, G. A.; McKhann, G.; McKiernan, J.; Neugut, A.; Olive, K.; Rosenblat, T.; Schwartz, G. K.; Shu, C.; Sisti, M.; Tergas, A.; Vattakalam, R.; Welch, M.; Wenske, S.; Wright, J. D.;
10.1101/2021.10.03.462951 — systems biology — Posted on 2021-11-04
3535 Modulations in motor unit discharge are related to changes in fascicle length during isometric contractions
Martinez-Valdes, E.; Negro, F.; Botter, A.; Pincheira, P. A.; Cerone, G. L.; Falla, D.; Lichtwark, G. A.; Cresswell, A. G.
10.1101/2021.04.27.441619 — physiology — Posted on 2021-11-04
3537 Anisotropic interaction and motion states of locusts in a hopper band
Weinburd, J.; Landsberg, J.; Kravtsova, A.; Lam, S.; Sharma, T.; Simpson, S. J.; Sword, G. A.; Buhl, J.
10.1101/2021.10.29.466390 — animal behavior and cognition — Posted on 2021-11-04
3538 Bovine pangenome reveals trait-associated structural variation from diverse assembly inputs
Leonard, A. S.; Crysnanto, D.; Fang, Z.-h.; Heaton, M. P.; Vander Ley, B. L.; Herrera, C.; Bollwein, H.; Bickhart, D. M.; Kuhn, K. L.; Smith, T. P. L.; Rosen, B. D.; Pausch, H.
10.1101/2021.11.02.466900 — genomics — Posted on 2021-11-04
3543 A life cycle alteration can correct molting defects in Caenorhabditis elegans
Binti, S.; Melinda, R. V.; Joseph, B. B.; Edeen, P. T.; Miller, S. D.; Fay, D. S.
10.1101/2021.11.02.466921 — developmental biology — Posted on 2021-11-04
3545 Structure Determination of Inactive-State GPCRs with a Universal Nanobody
Robertson, M. J.; He, F.; Meyerowitz, J. G.; Seven, A. B.; Panova, O.; Peroto, M.-C.; Che, T.; Skiniotis, G.
10.1101/2021.11.02.466983 — biophysics — Posted on 2021-11-04
3546 Metabolic heritage mapping: heterogenous pools of cytoplasmic nucleotide sugars are selectively utilized by various glycosyltransferases
Sosicka, P.; Ng, B. G.; Pepi, L. E.; Shajahan, A.; Wong, M.; Scott, D. A.; Matsumoto, K.; Xia, Z.-J.; Lebrilla, C. B.; Haltiwanger, R. S.; Azadi, P.; Freeze, H. H.
10.1101/2021.11.03.467160 — biochemistry — Posted on 2021-11-04
3547 Transcription factor induction of vascular blood stem cell niches in vivo
Hagedorn, E. J.; Perlin, J. R.; Freeman, R. J.; Wattrus, S. J.; Han, T.; Mao, C.; Kim, J. W.; Fernandez-Maestre, I.; Dailey, M. L.; D'Amato, C.; Fairchild, M. J.; Riquelme, R.; Li, B.; Ragoonanan, D. A.; Enkhbayar, K.; Henault, E. L.; Wang, H. G.; Redfield, S. E.; Collins, S. H.; Lichtig, A.; Yang, S.; Zhou, Y.; Kunar, B.; Gomez-Salinero, J. M.; Dinh, T. T.; Pan, J.; Holler, K.; Feldman, H. A.; Butcher, E. C.; van Oudenaarden, A.; Rafii, S.; Junker, J. P.; Zon, L. I.
10.1101/2021.11.03.467105 — developmental biology — Posted on 2021-11-04
3548 Trim41 is essential for preventing X chromosome chaotic synapsis in male mice
Oura, S.; Hino, T.; Satoh, T.; Noda, T.; Koyano, T.; Isotani, A.; Matsuyama, M.; Akira, S.; Ishiguro, K.-i.; Ikawa, M.
10.1101/2021.11.03.467045 — developmental biology — Posted on 2021-11-04
3549 Adar1 deletion causes degeneration of exocrine pancreas via Mavs-dependent interferon signaling
Rupani, D. N.; Cowan, R. W.; Thege, F. I.; Chandra, V.; Wormann, S. M.; Rajaei, H.; Malaney, P.; Le Roux, O.; Manning, S. L.; Hashem, J.; Bailey-Lundberg, J.; McAllister, F.; Rhim, A. D.
10.1101/2021.11.03.467127 — developmental biology — Posted on 2021-11-04
3552 An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures.
Shumeng, J.; Alisafaei, F.; Yuan, H.; Peng, X.; Huang, Y.-Y.; Miner, J. H.; Genin, G. M.; Suleiman, H. Y.
10.1101/2021.11.03.466963 — cell biology — Posted on 2021-11-04
3556 Montage electron tomography of vitrified specimens
Peck, A.; Carter, S. D.; Mai, H.; Chen, S.; Burt, A.; Jensen, G. J.
10.1101/2021.11.02.466666 — biophysics — Posted on 2021-11-04
3558 Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound
Tan, Y. Z.; Abbas, Y. M.; Wu, J. Z.; Wu, D.; Hesketh, G. G.; Bueler, S. A.; Gingras, A.-C.; Robinson, C. V.; Grinstein, S.; Rubinstein, J. L.
10.1101/2021.11.03.466369 — biochemistry — Posted on 2021-11-03
3561 Pan-primate DNA methylation clocks
Horvath, S.; Haghani, A.; Zoller, J. A.; Lu, A. T.; Ernst, J.; Pellegrini, M.; Jasinska, A. J.; Mattison, J. A.; Salmon, A. B.; Raj, K.; Horvath, M.; Paul, K. C.; Ritz, B. R.; Robeck, T. R.; Spriggs, M.; Ehmke, E.; Jenkins, S.; Li, C.; Nathanielsz, P. W.
10.1101/2020.11.29.402891 — developmental biology — Posted on 2021-11-03
3562 Inhibition of BET family proteins suppresses African swine fever virus infection
Niu, Q.; Zhao, Y.; Yang, S.; Yang, J.; Zhang, Z.; Geng, S.; Fan, J.; Liu, Z.; Guan, G.; Liu, Z.; Zhou, J.; Hu, H.; Luo, J.; Yin, H.
10.1101/2021.11.02.467039 — molecular biology — Posted on 2021-11-03
3563 Partial characterization and the evaluation of antimicrobial activities of silver nanoparticles biosynthesized from Cymbopogon citratus leaf extract
Rakib-Uz-Zaman, S. M.; Nimeree Muntasir, M.; Hoque Apu, E.; Mowna, S. A.; Khanom, M. G.; Jahan, S. S.; Akter, N.; R. Khan, M. A.; Shuborna, N. S.; Shams, S. M.; Khan, K.
10.1101/2021.11.01.466798 — molecular biology — Posted on 2021-11-03
3564 Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands
Nichols, A. L.; Blumenfeld, Z.; Fan, C.; Luebbert, L.; Blom, A. E. M.; Cohen, B. N.; Marvin, J. S.; Borden, P. M.; Kim, C.; Muthusamy, A. K.; Shivange, A. V.; Knox, H. J.; Campello, H. R.; Wang, J. H.; Dougherty, D. A.; Looger, L.; Gallagher, T.; Rees, D. C.; Lester, H. A.
10.1101/2021.10.04.463082 — pharmacology and toxicology — Posted on 2021-11-03
3565 A molecular network of conserved factors keeps ribosomes dormant in the egg
Leesch, K. F.; Lorenzo-Orts, L.; Pribitzer, C.; Grishkovskaya, I.; Matzinger, M.; Roitinger, E.; Belacic, K.; Kandolf, S.; Lin, T.-Y.; Mechtler, K.; Meinhart, A.; Haselbach, D.; Pauli, A.
10.1101/2021.11.03.467131 — biochemistry — Posted on 2021-11-03
3567 Trade-offs between cost of ingestion and rate of intake drive defensive toxin use
Douglas, T. E.; Beskid, S. G.; Gernand, C. E.; Nirtaut, B. E.; Tamsil, K. E.; Fitch, R. W.; Tarvin, R. D.
10.1101/2021.07.23.453507 — evolutionary biology — Posted on 2021-11-03
3569 Structural insights into human excitatory amino acid transporter EAAT2
Kato, T.; Kusakizako, T.; Jin, C.; Quan, L.; Ohgaki, R.; Okuda, S.; Kobayashi, K.; Yamashita, K.; Nishizawa, T.; Kanai, Y.; Nureki, O.
10.1101/2021.11.03.465409 — molecular biology — Posted on 2021-11-03
3573 DeepBacs: Bacterial image analysis using open-source deep learning approaches
Spahn, C.; Laine, R. F.; Pereira, P. M.; Gomez-de-Mariscal, E.; von Chamier, L.; Conduit, M.; Pinho, M. G.; Holden, S.; Jacquemet, G.; Heilemann, M.; Henriques, R.
10.1101/2021.11.03.467152 — microbiology — Posted on 2021-11-03
3580 Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex
Akey, C.; Singh, D.; Ouch, C.; Echeverria, I.; Nudelman, I.; Varberg, J. M.; Yu, Z.; Fang, F.; Shi, Y.; Wang, J.; Saltzberg, D.; Song, K.; Xu, C.; Gumbart, J.; Suslov, S.; Unruh, J.; Jaspersen, S. L.; Chait, B.; Sali, A.; Fernandez-Martinez, J.; Ludke, S. J.; Villa, E.; Rout, M.
10.1101/2021.10.29.466335 — biophysics — Posted on 2021-11-03
3581 NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes
Bao, H.; Carraro, M.; Flury, V.; Liu, Y.; Luo, M.; Chen, L.; Groth, A.; Huang, H.
10.1101/2021.11.02.467034 — biochemistry — Posted on 2021-11-03
3588 PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration
Beltra, M.; Pin, F.; Costamagna, D.; Duelen, R.; Renzini, A.; Ballaro, R.; Gracia-Castillo, L.; Iannuzzi, A.; Moresi, V.; Coletti, D.; Sampaolesi, M.; Penna, F.; Costelli, P.
10.1101/2021.11.03.466970 — molecular biology — Posted on 2021-11-03
3589 RAP1 regulates TIP60 function during fate transition between 2 cell-like and pluripotent states
Sfeir, A.; Barry, R.; Cote, J.; Mameri, A.; sacco, O.; Stojaspal, M.; Hofr, C.; Kartsonis, W.; Shah, P.; De Ioannes, P.
10.1101/2021.11.02.467017 — molecular biology — Posted on 2021-11-03
3594 Dense granule protein, GRA64 interacts with host cell ESCRT proteins during Toxoplasma gondii infection
Mayoral, J.; Guevara, R. B.; Rivera-Cuevas, Y.; Tu, V.; Tomita, T.; Romano, J. D.; Gunther-Cummins, L.; Sidoli, S.; Coppens, I.; Carruthers, V. B.; Weiss, L. M.
10.1101/2021.11.02.467042 — microbiology — Posted on 2021-11-03
3596 Discordance between different bioinformatic methods for identifying resistance genes from short-read genomic data, with a focus on Escherichia coli
Davies, T. J.; Swann, J.; Sheppard, A. E.; Pickford, H.; Lipworth, S.; AbuOun, M.; Ellington, M.; Fowler, P. W.; Hopkins, S.; Hopkins, K.; Crook, D.; Peto, T. E.; Anjum, M. F.; Walker, A. S.; Stoesser, N.
10.1101/2021.11.03.467004 — microbiology — Posted on 2021-11-03
3597 A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria
SWALE, C.; BELLINI, V.; Bowler, M. W.; NARDELLA, F.; Brenier-Pinchart, M.-P.; Cannella, D.; Belmudes, L.; MAS, C.; Coute, Y.; LAURENT, F.; Scherf, A.; BOUGDOUR, A.; HAKIMI, M.-a.
10.1101/2021.11.03.467097 — microbiology — Posted on 2021-11-03
3598 Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new tool to study their functional interplay within a single infected CD4+ T cell
Prevost, J.; Richard, J.; Gasser, R.; Medjahed, H.; Kirchhoff, F.; Hahn, B. H.; Kappes, J. C.; Ochsenbauer, C.; Duerr, R.; Finzi, A.
10.1101/2021.11.03.467116 — microbiology — Posted on 2021-11-03
3599 A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
Ramachandran, S.; Banerjee, N.; Bhattacharya, R.; Lemons, M. L.; Florman, J.; Lambert, C. M.; Touroutine, D.; Alexander, K.; Schoofs, L.; Alkema, M. J.; Beets, I.; Francis, M. M.
10.1101/2020.04.27.064550 — neuroscience — Posted on 2021-11-03
3600 Synergistic Coding of Carbon Dioxide and a Human Sweat Odorant in the Mosquito Brain
Shankar, S.; Tauxe, G. M.; Spikol, E. D.; Li, M.; Akbari, O. S.; Giraldo, D.; McMeniman, C. J.
10.1101/2020.11.02.365916 — neuroscience — Posted on 2021-11-03
3602 Altered synaptic connectivity in an in vitro human model of STXBP1 encephalopathy
McLeod, F.; Dimtsi, A.; Lewis-Smith, D.; Thomas, R.; Clowry, G. J.; Trevelyan, A. J.
10.1101/2021.09.22.461333 — neuroscience — Posted on 2021-11-03
3604 Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2
Hussain, T.; Afsar, M.; Narayan, R.; Akhtar, M. N.; Rahil, H.; Eswarappa, S.; Tripathi, S.
10.1101/2021.11.02.466951 — biophysics — Posted on 2021-11-03
3606 Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function
Popovic, B.; Guislain, A.; Engels, S.; Nicolet, B.; Jurgens, A. P.; Paravinja, N.; Freen-van Heeren, J. J.; van Alphen, F. P.; van den Biggelaar, M.; Salerno, F.; Wolkers, M.
10.1101/2021.11.03.467112 — immunology — Posted on 2021-11-03
3609 Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus
Harris, R. A.; Raveendran, M.; Lyfoung, D. T.; Sedlazeck, F. J.; Mahmoud, M.; Prall, T.; Karl, J.; Doddapaneni, H.; Meng, Q.; Han, Y.; Muzny, D.; Wiseman, R. W.; O'Connor, D. H.; Rogers, J.
10.1101/2021.07.05.451071 — genomics — Posted on 2021-11-03
3610 The origin of asexual brine shrimps
Rode, N. O.; Jabbour-Zahab, R.; Boyer, L.; Flaven, E.; Hontoria, F.; Van Stappen, G.; Dufresne, F.; Haag, C. R.; Lenormand, T.
10.1101/2021.06.11.448048 — evolutionary biology — Posted on 2021-11-03
3613 The memory of airway epithelium damage in smokers and COPD patients
Carlier, F. M.; Detry, B.; Lecocq, M.; Collin, A. M.; Plante-Bordeneuve, T.; Verleden, S. E.; Stanciu-Pop, C.; Janssens, W.; Ambroise, J.; Vanaudenaerde, B. M.; Gohy, S. T.; Pilette, C.
10.1101/2021.04.21.439437 — pathology — Posted on 2021-11-03
3618 Global patterns and rates of habitat transitions across the eukaryotic tree of life
Jamy, M.; Biwer, C.; Vaulot, D.; Obiol, A.; Jing, H.; Peura, S.; Massana, R.; Burki, F.
10.1101/2021.11.01.466765 — evolutionary biology — Posted on 2021-11-03
3623 SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression
Salasova, A.; Degn, N. S.; Paveliev, M.; Madsen, N. K.; Benito, S.; Casarotto, P.; Ovesen, P. L.; Vestergaard, B.; Udrea, A. C.; Kisiswa, L.; Woloszczukova, L.; Faress, I.; Nabavi, S.; Castren, E.; Arevalo, J.; Holm, M. M.; Kjolby, M.; Bolcho, U.; Nykjaer, A.
10.1101/2021.11.03.466767 — neuroscience — Posted on 2021-11-03
3625 A prior exposure to Serratia marcescens or xenobiotics primes Drosophila enterocytes against a recurring cytoplasmic purge
Terreri, S.; Sina-Rahme, B.; Pais, I. S.; Socha, C.; Lestradet, M.; Yamba, W. M.; Schirmeier, S.; Lee, K.-Z.; Ferrandon, D.
10.1101/2021.10.31.466690 — physiology — Posted on 2021-11-03
3626 Cooperative electrolyte-PEG interactions drive the signal amplification in a solid-state nanopore
Chau, C. C.; Marcuccio, F.; Soulias, D.; Edwards, M. A.; Radford, S. E.; Hewitt, E. W.; Actis, P.
10.1101/2021.11.01.466478 — biophysics — Posted on 2021-11-03
3627 A low-resource reliable pipeline to democratize multi-modal connectome estimation and analysis
Lawrence, R.; Loftus, A.; Kiar, G.; Bridgeford, E.; Consortium for Reliability and Reproducibility, ; Chandrashekhar, V.; Mhembere, D.; Ryman, S.; Zuo, X.-N.; Margulies, D.; Craddock, R. C.; Priebe, C. E.; Jung, R.; Calhoun, V. D.; Caffo, B.; Burns, R.; Milham, M. P.; Vogelstein, J.
10.1101/2021.11.01.466686 — bioinformatics — Posted on 2021-11-03
3628 RNA splicing analysis using heterogeneous and large RNA-seq1datasets
Vaquero-Garcia, J.; Aicher, J. K.; Jewell, P.; Gazzara, M. R. K.; Radens, C. M.; Jha, A.; Green, C. J.; Norton, S. S.; Lahens, N. F.; Grant, G. R.; Barash, Y.
10.1101/2021.11.03.467086 — bioinformatics — Posted on 2021-11-03
3629 Host Variation in Interferon, MHC Class I, Glycosylation, and Viral Transcription Genes Predict HIV Persistence
Siegel, D. A.; Thanh, C.; Wan, E.; Hoh, R.; Hobbs, K.; Pan, T.; Gibson, E. A.; Kroetz, D. L.; Hunt, P. W.; Marin, J.; Hecht, F.; Pilcher, C.; Milush, J.; Martin, M.; Carrington, M.; Pillai, S.; Busch, M. P.; Stone, M.; Huang, M.-L.; Roychoundhury, P.; Haworth, K.; Jerome, K. R.; Kiem, H.-P.; Heinrich, T. J.; Deeks, S. G.; Lee, S.
10.1101/2021.10.31.466670 — genomics — Posted on 2021-11-03
3630 Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries
Smith, S. P.; Shahamatdar, S.; Cheng, W.; Zhang, S.; Paik, J.; Graff, M.; Haiman, C. A.; Matise, T. C.; North, K. E.; Peters, U.; Kenny, E.; Gignoux, C. R.; Wojcik, G. L.; Crawford, L.; Ramachandran, S.
10.1101/2021.04.20.440612 — genomics — Posted on 2021-11-03
3631 Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury
Wasserman, A. H.; Lewis-Israeli, Y. R.; Huang, A. R.; Dooley, M. D.; Mitchell, A. L.; Venkatesan, M.; Aguirre, A.
10.1101/2021.11.01.466355 — developmental biology — Posted on 2021-11-03
3632 Content-aware frame interpolation (CAFI): Deep Learning-based temporal super-resolution for fast bioimaging
Priessner, M.; Gaboriau, D. C. A.; Sheridan, A.; Lenn, T.; Chubb, J. R.; Manor, U.; Vilar Compte, R.; Laine, R. F.
10.1101/2021.11.02.466664 — cell biology — Posted on 2021-11-03
3633 Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation
Takele, Y.; Adem, E.; Franssen, S. U.; Womersley, R.; Kaforou, M.; Levin, M.; Muller, I.; Cotton, J. A.; Kropf, P.
10.1101/2021.11.01.466750 — immunology — Posted on 2021-11-03
3634 Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse
Richardson, A.; Ciampani, V.; Stancu, M.; Newton, S.; Steinert, J. R.; Pilati, N.; Graham, B. P.; Kopp-Scheinpflug, C.; Forsythe, I. D.
10.1101/2021.11.02.466934 — neuroscience — Posted on 2021-11-03
3635 Dysconnectivity between auditory-cognitive network associated with auditory GABA and glutamate levels in presbycusis patients
Li, N.; Ma, W.; Ren, F.; Li, X.; Li, F.; Zong, W.; Wu, L.; Dai, Z.; Hui, S. C. N.; Edden, R. A. E.; Li, M.; Gao, F.
10.1101/2021.10.31.466279 — neuroscience — Posted on 2021-11-03
3636 Manipulating neural dynamics to tune motion detection
Gonzalez-Suarez, A. D.; Zavatone-Veth, J. A.; Chen, J.; Matulis, C.; Badwan, B.; Clark, D. A.
10.1101/2021.11.02.466844 — neuroscience — Posted on 2021-11-03
3639 Motor unit recruitment strategies of the vastus lateralis according to sex
Guo, Y.; Jones, E. J.; Inns, T. B.; Ely, I. A.; Stashuk, D. W.; Wilkinson, D. J.; Smith, K.; Piasecki, J.; Phillips, B. E.; Atherton, P. J.; Piasecki, M.
10.1101/2021.11.01.466761 — physiology — Posted on 2021-11-03
3642 Multiplexed Single-Molecule Epigenetic Analysis of Plasma-Isolated Nucleosomes for Cancer Diagnostics
Fedyuk, V.; Erez, N.; Furth, N.; Beresh, O.; Jones, D.; Shinde, A.; Andreishcheva, K.; Zakai, B. B.; Mavor, Y.; Peretz, T.; Hubert, A.; Cohen, J. E.; Salah, A.; Temper, M.; Grinshpun, A.; Maoz, M.; Zick, A.; Ron, G.; Shema, E.
10.1101/2021.11.01.466724 — cancer biology — Posted on 2021-11-03
3643 AbDiver - A tool to explore the natural antibody landscape to aid therapeutic design
Mlokosiewicz, J.; Deszynski, P.; Wilman, W.; Jaszczyszyn, I.; Ganesan, R.; Kovaltsuk, A.; Leem, J.; Galson, J.; Krawczyk, K.
10.1101/2021.11.03.467080 — bioinformatics — Posted on 2021-11-03
3646 Comparative genomics among three cyst nematode species reveals distinct evolutionary histories among effector families and an irregular distribution of effector-associated promoter motifs
van Steenbrugge, J. J. M.; van den Elsen, S.; Holterman, M.; Lozano-Torres, J. L.; Putker, V.; Thorpe, P.; Goverse, A.; Sterken, M. G.; Smant, G.; Helder, J.
10.1101/2021.11.01.466756 — genomics — Posted on 2021-11-03
3647 Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut
Bakkeren, E.; Herter, J. A.; Huisman, J. S.; Steiger, Y.; Gul, E.; Newson, J. P. M.; Brachmann, A. O.; Piel, J.; Regoes, R. R.; Bonhoeffer, S.; Diard, M.; Hardt, W.-D.
10.1101/2021.04.08.438970 — evolutionary biology — Posted on 2021-11-03
3649 Long-term forest monitoring unravels constant mortality rise in European forests
George, J.-P.; Sanders, T. G.; Neumann, M.; Cammalleri, C.; Vogt, J. V.; Lang, M.
10.1101/2021.11.01.466723 — ecology — Posted on 2021-11-03
3651 Drop, Swap, and Generate: A Self-Supervised Approach for Generating Neural Activity
Liu, R.; Azabou, M.; Dabagia, M.; Lin, C.-H.; Azar, M. G.; Hengen, K. B.; Valko, M.; Dyer, E. L.
10.1101/2021.07.21.453285 — neuroscience — Posted on 2021-11-03
3652 Overlapping Representation of Basic Tastes in the Human Gustatory Cortex
Zhang, D.; Wang, X.; Wang, Y.; Nguchu, B. A.; Jiang, Z.; Shi, C.; Qiu, B.
10.1101/2021.10.31.466657 — neuroscience — Posted on 2021-11-03
3654 Tonic engagement of nicotinic receptors bidirectionally controls striatal spiny projection neuron spike timing
Matityahu, L.; Malgady, J.; Schirelman, M.; Johansson, Y.; Wilking, J.; Silberberg, G.; Goldberg, J. A.; Plotkin, J. L.
10.1101/2021.11.02.466870 — neuroscience — Posted on 2021-11-03
3657 Platelet generation from circulating megakaryocytes is triggered in the lung vasculature
Zhao, X.; Alibhai, D.; Walsh, T. G.; Tarassova, N.; Birol, S. Z.; Williams, C. M.; Neil, C. R.; Aitken, E. W.; Waller, A. K.; Ballester-Beltran, J.; Gunning, P. W.; Hardeman, E. C.; Agbani, E. O.; Hers, I.; Ghevaert, C.; Poole, A. W.
10.1101/2021.11.01.466743 — physiology — Posted on 2021-11-03
3658 Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer
Young, R. S. E.; Bowman, A. P.; Tousignant, K. D.; Poad, B. L. J.; Gunter, J. H.; Philp, L. K.; Nelson, C. C.; Ellis, S.; Heeren, R. M. A.; Sadowski, M. C.; Blanksby, S. J.
10.1101/2021.11.01.466716 — cancer biology — Posted on 2021-11-03
3660 Biological network inference from single-cell multi-omics data using heterogeneous graph transformer
Ma, A.; Wang, X.; Wang, C.; Li, J.; Xiao, T.; Wang, J.; Chang, Y.; Li, Y.; Liu, Y.; Gu, S.; Wang, D.; Jiang, Y.; Li, J.; Su, L.; Li, Z.; Liu, B.; Xu, D.; Ma, Q.
10.1101/2021.10.31.466658 — bioinformatics — Posted on 2021-11-03
3662 Transcriptional integration of distinct microbial and nutritional signals by the small intestinal epithelium
Lickwar, C. R.; Davison, J. M.; Kelly, C.; Padilla Mercado, G.; Wen, J.; Davis, B. R.; Tillman, M. C.; Semova, I.; Andres, S. F.; Vale, G.; McDonald, J. G.; Rawls, J. F.
10.1101/2021.11.01.465976 — genomics — Posted on 2021-11-03
3664 Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis
Zhu, L.; Kamalathevan, P.; Koneva, L.; Miotla Zarebska, J.; Chanalaris, A.; Ismail, H.; Wiberg, A.; Ng, M.; Muhammed, H.; Watt, F.; Sansom, S.; Furniss, D.; Gardiner, M.; Vincent, T. L.
10.1101/2021.09.10.457848 — molecular biology — Posted on 2021-11-03
3666 The NK receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
Sen Santara, S.; Crespo, A. C.; Lee, D.-J.; Hu, J.; Zhang, Y.; Chowdhury, S.; Meza-Sosa, K. F.; Rowe, M.; McClelland, A.; Wu, H.; Junqueira, C.; Lieberman, J.
10.1101/2021.10.31.466654 — immunology — Posted on 2021-11-03
3668 4-aminopyridine promotes accelerated skin wound healing.
Mashanipalya Guddadarangaiah, J.; Govindappa, P. K.; Nelson, A. M.; Noble, M. D.; Elfar, J.
10.1101/2021.10.31.465317 — neuroscience — Posted on 2021-11-03
3670 Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis
Berland, C.; Castel, J.; Terrasi, R.; Montalban, E.; Foppen, E.; Martin, C.; Muccioli, G. G.; Luquet, S.; Gangarossa, G.
10.1101/2020.11.14.382291 — neuroscience — Posted on 2021-11-03
3671 More than a feeling: scalp EEG and eye correlates of conscious tactile perception
Gusso, M. M.; Christison-Lagay, K. L.; Zuckerman, D.; Chandrasekaran, G.; Kronemer, S. I.; Ding, J. Z.; Freedman, N. C.; Nohama, P.; Blumenfeld, H.
10.1101/2021.10.31.466706 — neuroscience — Posted on 2021-11-03
3672 Chronic Cochlear Implantation with and without Electric Stimulation in a Mouse Model Induces Robust Cochlear Influx of CX3CR1+/GFP Macrophages.
Claussen, A. D.; Vielman Quevedo, R.; Higgins, T.; Mostaert, B.; Taifur Rahman, M.; Kirk, J. R.; Hirose, K.; Hansen, M. R.
10.1101/2021.10.31.466540 — neuroscience — Posted on 2021-11-03
3678 Tissue homeostasis in sponges: quantitative analysis of cell proliferation and apoptosis
Melnikov, N. P.; Bolshakov, F. V.; Frolova, V. S.; Skorentseva, K. V.; Ereskovsky, A. V.; Saidova, A. A.; Lavrov, A. I.
10.1101/2021.10.31.466669 — zoology — Posted on 2021-11-03
3679 Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling
Zaidi, S.; Zhao, J. L.; Chan, J. M.; Roudier, M. P.; Wadosky, K. M.; Gopalan, A.; Karthaus, W. R.; Choi, J.; Lawrence, K.; Chaudhary, O.; Xu, T.; Masilionis, I.; Mazutis, L.; Chaligne, R.; Linkov, I.; Barlas, A.; Jungbluth, A.; Rekhtman, N.; Silber, J.; Manova Todorova, K.; Watson, P. A.; True, L. D.; Nelson, P. S.; Scher, H. I.; Rathkopf, D. E.; Morris, M. J.; Haffner, M. C.; Goodrich, D. W.; Pe'er, D.; Sawyers, C. L.
10.1101/2021.11.01.466599 — cancer biology — Posted on 2021-11-03
3680 Removing unwanted variation from large-scale cancer RNA-sequencing data
Molania, R.; Foroutan, M.; Gagnon-Bartsch, J.; Gandolfo, L.; Olshansky, G.; Dobrovic, A.; Papenfuss, A. T.; Speed, T. P.
10.1101/2021.11.01.466731 — bioinformatics — Posted on 2021-11-03
3682 Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology
Mills, C. E.; Waltmann, C.; Archer, A. G.; Kennedy, N. W.; Abrahamson, C. H.; Jackson, A. D.; Roth, E. W.; Shirman, S.; Jewett, M. C.; Mangan, N. M.; Olvera de la Cruz, M.; Tullman-Ercek, D.
10.1101/2021.10.31.466680 — bioengineering — Posted on 2021-11-03
3683 Hydrogel injection molding to generate complex cell encapsulation geometries
McCall, A. B.; Emerson, A. E.; Brady, S. R.; Slaby, E. M.; Weaver, J. D.
10.1101/2021.10.31.466681 — bioengineering — Posted on 2021-11-03
3684 Identifying metabolic adaptations during cardiotoxicity using paired transcriptomics andmetabolomics data integrated with a model of heart metabolism
Dougherty, B.; Rawls, K. D.; Jenior, M. L.; Chun, B.; Nagdas, S.; Saucerman, J. J.; Kolling, G. L.; Wallqvist, A.; Papin, J. A.
10.1101/2021.10.31.466544 — bioengineering — Posted on 2021-11-03
3685 Alone Again: Altered Activation in the Observation Execution System during Synchronization in High Loneliness Individuals
Saporta, N.; Scheele, D.; Lieberz, J.; Nevat, M.; Kanterman, A.; Hurlemann, R.; Shamay-Tsoory, S. G.
10.1101/2021.10.17.464634 — neuroscience — Posted on 2021-11-03
3687 Genetic Mouse Models of Autism Spectrum Disorder Present Subtle Heterogenous Cardiac Abnormalities.
Assimopoulos, S.; Hammill, C.; Fernandes, D. J.; Spencer Noakes, T. L.; Zhou, Y.-Q.; Nutter, L. M.; Ellegood, J.; Anagnostou, E.; Sled, J. G.; Lerch, J. P.
10.1101/2021.10.19.465007 — neuroscience — Posted on 2021-11-03
3689 Dominant species determine ecosystem stability across scales in Inner Mongolian grassland
Wang, Y.; Wang, S.-P.; Zhao, L.; Liang, C.; Miao, B.; Zhang, Q.; Niu, X.; Ma, W.; Schmid, B.
10.1101/2021.10.31.466650 — ecology — Posted on 2021-11-03
3691 Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
Costa, V. V.; Sugimoto, M. A.; Hubner, J.; Bonilha, C. S.; Queiroz-Junior, C. M.; Goncalves-Pereira, M. H.; Chen, J.; Gobbetti, T.; Libanio Rodrigues, G. O.; Bambirra, J. L.; Passos, I. B.; Machado Lopes, C. E.; Moreira, T. P.; Bonjour, K.; Melo, R. C. N.; Oliveira, M. A. P.; Andrade, M. V. M.; Sousa, L. P.; Souza, D. G.; Santiago, H. d. C.; Perretti, M.; Teixeira, M. M.
10.1101/2021.11.02.466887 — microbiology — Posted on 2021-11-03
3696 Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections
Rozman, B.; Nachshon, A.; Samia, R. L.; Lavi, M.; Schwartz, M.; Stern-Ginossar, N.
10.1101/2021.07.26.453763 — microbiology — Posted on 2021-11-03
3701 An atlas of lamina-associated chromatin across twelve human cell types revealsan intermediate chromatin subtype
Keough, K. C.; Shah, P. P.; Gjoni, K.; Santini, G. T.; Wickramasinghe, N. M.; Dundes, C. E.; Karnay, A.; Chen, A.; Salomon, R. E. A.; Walsh, P. J.; Nguyen, S. C.; Whalen, S.; Joyce, E. F.; Loh, K. M.; Dubois, N.; Pollard, K. S.; Jain, R.
10.1101/2020.07.23.218768 — developmental biology — Posted on 2021-11-02
3702 Self-organized emergence of hyaline cartilage in hiPSC-derived multi-tissue organoids
Li, M.; Abrahante, J. E.; Vegoe, A.; Chai, Y. W.; Lindborg, B.; Toth, F.; Larsen, P. A.; O'Brien, T. D.
10.1101/2021.09.21.461213 — cell biology — Posted on 2021-11-02
3706 Efficient Coding in the Economics of Human Brain Connectomics
Zhou, D.; Lynn, C. W.; Cui, Z.; Ciric, R.; Baum, G. L.; Moore, T. M.; Roalf, D. R.; Detre, J. A.; Gur, R. C.; Gur, R. E.; Satterthwaite, T. D.; Bassett, D. S.
10.1101/2020.01.14.906842 — neuroscience — Posted on 2021-11-02
3707 Spatial structure, phase, and the contrast of natural images
Rideaux, R.; West, R. K.; Wallis, T. S. A.; Bex, P. J.; Mattingley, J. B.; Harrison, W. J.
10.1101/2021.06.16.448761 — neuroscience — Posted on 2021-11-02
3714 The colonial legacy of herbaria
Park, D. S.; Feng, X.; Akiyama, S.; Ardiyani, M.; Avendano, N.; Barina, Z.; Bartschi, B.; Belgrano, M.; Betancur, J.; Bijmoer, R.; Bogaerts, A.; Cano, A.; Danihelka, J.; Garg, A.; Giblin, D. E. E.; Gogoi, R.; Guggisberg, A.; Hyvarinen, M.; James, S. A.; Sebola, R. J.; Katagiri, T.; Kennedy, J. A.; Komil, T. S.; Lee, B.; Lee, S. M. L.; Magri, D.; Marcucci, R.; Masinde, S.; Melnikov, D.; Mraz, P.; Mulenko, W.; Musili, P.; Mwachala, G.; Nelson, B. E.; Niezgoda, C.; Novoa, C.; Orli, S.; Paton, A.; Payette, S.; Perkins, K. D.; Ponce, M.; Rainer, H.; Rasingam, L.; Rustiami, H.; Shiyan, N. M.; Slette
10.1101/2021.10.27.466174 — ecology — Posted on 2021-11-02
3715 Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth
Santos, M.; Ferreira, M.; Oliveira, P.; Mendes, N.; Andre, A.; Vieira, A. F.; Nunes, J. B.; Carvalho, J.; Rocha, S.; Azevedo, M.; Ferreira, D.; Reis, I.; Vinagre, J.; Paredes, J.; Heravi-Moussavi, A.; Lima, J.; Maximo, V.; Burleigh, A.; Roskelley, C.; Carneiro, M. F.; Huntsman, D.; Oliveira, C.
10.1101/2021.11.02.466914 — cell biology — Posted on 2021-11-02
3716 Size-independent mRNA synthesis and chromatin-based partitioning mechanisms generate and maintain constant amounts of protein per cell
Swaffer, M. P.; Kim, J.; Chandler-Brown, D.; Langhinrichs, M.; Marinov, G.; Greenleaf, W.; Kundaje, A.; Schmoller, K. M.; Skotheim, J. M.
10.1101/2020.08.28.272690 — cell biology — Posted on 2021-11-02
3717 Artificial intelligence reveals nuclear pore complexity
Mosalaganti, S.; Obarska-Kosinska, A.; Siggel, M.; Turonova, B.; Zimmerli, C. E.; Buczak, K.; Schmidt, F.; Margiotta, E.; Mackmull, M.-T.; Hagen, W.; Hummer, G.; Beck, M.; Kosinski, J.
10.1101/2021.10.26.465776 — molecular biology — Posted on 2021-11-02
3721 Microglia-specific promoter activities of human HexB gene
Shah, S.; Wong, L.; Ellis, K.; Bondar, B.; Saribas, S.; Ting, J.; Wei, Z.; Wang, X.; Wang, H.; Tang, Y.; Lin, B.; Margolis, D. M.; Garcia, J. V.; Hu, W.; Jiang, G.
10.1101/2021.10.28.465974 — neuroscience — Posted on 2021-11-02
3725 Tree invasions threaten the conservation potential and sustainability of U.S.rangelands
Morford, S. L.; Allred, B. W.; Twidwell, D.; Jones, M. O.; Maestas, J. D.; Naugle, D. E.
10.1101/2021.04.02.438282 — ecology — Posted on 2021-11-02
3727 Respiration, heartbeat, and conscious tactile perception
Grund, M.; Al, E.; Pabst, M.; Dabbagh, A.; Stephani, T.; Nierhaus, T.; Gaebler, M.; Villringer, A.
10.1101/2021.03.22.436396 — neuroscience — Posted on 2021-11-02
3729 Programmable large DNA deletion, replacement, integration, and inversion with twin prime editing and site-specific recombinases
Anzalone, A.; Gao, X.; Podracky, C.; Nelson, A.; Koblan, L.; Raguram, A.; Levy, J.; Mercer, J.; Liu, D.
10.1101/2021.11.01.466790 — genomics — Posted on 2021-11-02
3730 Dephosphorylation of the pre-initiation complex during S-phase is critical for origin firing
Jenkinson, F. L. V.; Tan, K. W.; Schöpf, B.; Santos, M. M.; Phanada, I.; Zegerman, P.
10.1101/2021.11.02.466916 — cell biology — Posted on 2021-11-02
3731 Bright, fluorogenic and photostable avidity probes for RNA imaging
Bühler, B.; Benderoth, A.; Englert, D.; Grün, F.; Schokolowski, J.; Jäschke, A.; Sunbul, M.
10.1101/2021.11.02.466936 — molecular biology — Posted on 2021-11-02
3732 Marker-free coselection for successive rounds of prime editing in human cells
Levesque, S.; Mayorga, D.; Fiset, J.-P.; Goupil, C.; Duringer, A.; Loiselle, A.; Bouchard, E.; Agudelo, D.; Doyon, Y.
10.1101/2021.11.02.464583 — molecular biology — Posted on 2021-11-02
3735 A critical role for E2-p53 interaction during the human papillomavirus 16 life cycle
Fontan, C. T.; James, C. D.; Bristol, M. L.; Prabhakar, A. T.; Otoa, R.; Wang, X.; Karimi, E.; Rajagopalan, P.; Basu, D.; Morgan, I. M.
10.1101/2021.11.01.466861 — molecular biology — Posted on 2021-11-02
3737 Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
Bowness, J. S.; Nesterova, T. B.; Wei, G.; Rodermund, L.; Almeida, M.; Coker, H.; Carter, E. J.; Kadaster, A.; Brockdorff, N.
10.1101/2021.11.02.466758 — molecular biology — Posted on 2021-11-02
3738 mRNA Vaccines Induce Rapid Antibody Responses in Mice
Gebre, M.; Rauch, S.; Roth, N.; Gergen, J.; Yu, J.; Liu, X.; Cole, A.; Mueller, S.; Petsch, B. W.; Barouch, D. H.
10.1101/2021.11.01.466863 — microbiology — Posted on 2021-11-02
3741 Detection of velogenic avian paramyxoviruses in rock doves in New York City, New York
Francisco, I.; Bailey, S.; Bautista, T.; Diallo, D.; Gonzalez, J.; Gonzalez, J.; Roubidoux, E. K.; Ajayi, P. K.; Albrecht, R. A.; McMahon, R.; Krammer, F.; Marizzi, C.
10.1101/2021.11.02.467002 — microbiology — Posted on 2021-11-02
3744 Maize AFP1 confers antifungal activity by inhibiting chitin deacetylases from a broad range of fungi
Ma, L.-S.; Tsai, W.-L.; Kalunke, R. M.; Xu, M.-Y.; Lin, Y.-H.; Damei, F. A.; Lee, H.-C.
10.1101/2021.11.02.466889 — microbiology — Posted on 2021-11-02
3745 JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance
Deng, S.; Wang, C.; Wang, Y.; Xu, Y.; Li, X.; Johnson, N.; Lo, U.-G.; Xu, L.; Gonzalez, J.; Metang, L.; Ye, J.; Tirado, C. R.; Rodarte, K.; Xie, Z.; Arana, C.; Annamalai, V.; Hsieh, J.-T.; Griend, D. V.; Li, B.; Wang, T.; Mu, P.
10.1101/2021.11.02.466956 — cancer biology — Posted on 2021-11-02
3747 ParS-independent recruitment of the bacterial chromosome-partitioning protein ParB
Tisma, M.; Panoukidou, M.; Antar, H.; Soh, Y.-M.; Barth, R.; Pradhan, B.; van der Torre, J.; Michieletto, D.; Gruber, S.; Dekker, C.
10.1101/2021.11.02.466941 — biophysics — Posted on 2021-11-02
3748 Tau differentially regulates the transport of early endosomes and lysosomes
Balabanian, L.; Lessard, D. V.; Yaninska, P.; Stevens, P. W.; Wiseman, P. W.; Berger, C. L.; Hendricks, A. G.
10.1101/2021.11.01.466759 — biophysics — Posted on 2021-11-02
3749 Annexin A4 senses membrane curvature in a density-dependent manner
Florentsen, C. D.; Daniels, J. A.; Moreno-Pescador, G.; Qoqaj, I.; Nylandsted, J.; Bendix, P. M.
10.1101/2021.11.02.466919 — biophysics — Posted on 2021-11-02
3751 The effect of acute oral galactose administration on the redox system of the rat small intestine
Homolak, J.; Babic Perhoc, A.; Knezovic, A.; Osmanovic Barilar, J.; Virag, D.; Joja, M.; Salkovic-Petrisic, M.
10.1101/2021.11.02.466954 — biochemistry — Posted on 2021-11-02
3752 Reconstitution of ATP-dependent 3'-cleavage of mammalian pre-mRNA reveals a central role of RBBP6
Schmidt, M.; Kluge, F.; Sandmeir, F.; Schäfer, P.; Tüting, C.; Ihling, C.; Kühn, U.; Conti, E.; Wahle, E.
10.1101/2021.11.02.466878 — biochemistry — Posted on 2021-11-02
3753 N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processing
Kliza, K. W.; Song, W.; Pinzuti, I.; Schaubeck, S.; Kunzelmann, S.; Kuntin, D.; Fornili, A.; Pandini, A.; Hofmann, K.; Garnett, J.; Stieglitz, B.; Husnjak, K.
10.1101/2021.11.02.466974 — biochemistry — Posted on 2021-11-02
3756 Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination
Kim, W.; Zhou, J. Q.; Sturtz, A. J.; Horvath, S. C.; Schmitz, A. J.; Lei, T.; Kalaidina, E.; Thapa, M.; Al Soussi, W. B.; Haile, A.; Klebert, M. K.; Suessen, T.; Parra-Rodriguez, L.; Mudd, P. A.; Middleton, W. D.; Teefy, S. A.; Pusic, I.; O'Halloran, J. A.; Presti, R. M.; Turner, J. S.; Ellebedy, A. H.
10.1101/2021.10.31.466651 — immunology — Posted on 2021-11-02
3757 A vitamin D-RelB/NF-κB pathway limits Chandipura virus multiplication by rewiring the homeostatic state of autoregulatory type 1 interferon-IRF7 signaling
Ratra, Y.; Kumar, N.; Saha, M. K.; Bharadwaj, C.; Chongtham, C.; Bais, S. S.; Medigeshi, G. R.; Arimbasseri, G. A.; Basak, S.
10.1101/2021.11.01.466649 — immunology — Posted on 2021-11-02
3758 Powerful synergistic effects of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I+ tumors
Wolf, N. K.; Blaj, C.; Picton, L.; Snyder, G.; Zhang, L.; Nicolai, C. J.; Ndubaku, C. O.; McWhirter, S. M.; Garcia, K. C.; Raulet, D. H.
10.1101/2021.11.02.465022 — immunology — Posted on 2021-11-02
3760 Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B
Ryan, S. K.; Zelic, M.; Han, Y.; Teeple, E.; Chen, L.; Sadeghi, M.; Shankara, S.; Guo, L.; Li, C.; Pontarelli, F.; Jensen, E. H.; Kumar, D.; Zhang, M.; Gans, J.; Zhang, B.; Proto, J.; Saleh, J.; Dodge, J. C.; Rajpal, D.; Ofengeim, D.; Hammond, T. R.
10.1101/2021.11.02.466996 — neuroscience — Posted on 2021-11-02
3761 Diversity, function and evolution of marine invertebrate genomes
Fan, G.; Zhang, Y.; Wang, J.; Lv, M.; Gao, H.; Meng, L.; A, Y.; Seim, I.; Zhang, H.; Liu, S.; Zhang, L.; Liu, X.; Xu, X.; Yang, H.
10.1101/2021.10.31.465852 — genomics — Posted on 2021-11-02
3763 Effects of upgrading acquisition-techniques and harmonization methods: A multi-modal MRI study with implications for longitudinal designs
Itahashi, T.; Aoki, Y. Y.; Yamashita, A.; Soda, T.; Fujino, J.; Ohta, H.; Aoki, R.; Nakamura, M.; Kato, N.; Tanaka, S. C.; Kokuryo, D.; Hashimoto, R.-i.
10.1101/2021.10.31.466635 — neuroscience — Posted on 2021-11-02
3764 AAV9-MCT8 delivery at juvenile stage ameliorates neurological and behavioral deficits in an AHDS mouse model
Liao, X.-H.; Avalos, P.; Oksana, S.; Ofan, R.; Shilo, M.; Bresee, C.; Likhite, S.; Vit, J.-P.; Heuer, H.; Kaspar, B.; Kathrin, M.; Dumitrescu, A. M.; Refetoff, S.; Svendsen, C. N.; Vatine, G. D.
10.1101/2021.10.31.466634 — neuroscience — Posted on 2021-11-02
3767 Hepatocyte cholesterol content modulates glucagon receptor signalling
McGlone, E. R.; Ansell, T. B.; Dunsterville, C.; Song, W.; Carling, D.; Tomas, A.; Bloom, S. R.; Sansom, M.; Tan, T. M.; Jones, B.
10.1101/2021.10.31.466084 — pharmacology and toxicology — Posted on 2021-11-02
3774 Hummingbird abundance is related to food resources availability in a temperate forest of central Mexico
Vazquez-Buitron, M. A.; Salinas-Melgoza, M. A.; Salinas-Melgoza, V.; Salinas-Melgoza, A.
10.1101/2021.10.30.466620 — ecology — Posted on 2021-11-02
3775 Wildlife is imperiled in peri-urban landscapes: threats to arboreal mammals
Chaves, O. M.; Souza, J. C.; Buss, G.; Hirano, Z. M. B.; Jardim, M. M. A.; Amaral, E.; Godoy, J. C.; Peruchi, A. R.; Michel, T.; Bicca-Marques, J. C.
10.1101/2021.10.30.466631 — ecology — Posted on 2021-11-02
3777 A feedback loop between heterochromatin and the nucleopore complex controls germ-cell to oocyte transition during Drosophila oogenesis
Sarkar, K.; Kotb, N. M.; Lemus, A.; Martin, E. T.; McCarthy, A.; Camacho, J.; Iqbal, A.; Valm, A. M.; Sammons, M. A.; Rangan, P.
10.1101/2021.10.31.466575 — developmental biology — Posted on 2021-11-02
3778 A new tripartite landmark in posterior cingulate cortex
Willbrand, E. H.; Parker, B. J.; Voorhies, W. I.; Miller, J. A.; Lyu, I.; Hallock, T.; Aponik-Gremillion, L.; Bunge, S.; Foster, B. L.; Weiner, K. S.
10.1101/2021.10.30.466521 — neuroscience — Posted on 2021-11-02
3779 Explaining heterogeneity in medial entorhinal cortex with task-driven neural networks
Nayebi, A.; Attinger, A.; Campbell, M. G.; Hardcastle, K.; Low, I. I. C.; Mallory, C. S.; Mel, G. C.; Sorscher, B.; Williams, A. H.; Ganguli, S.; Giocomo, L. M.; Yamins, D. L. K.
10.1101/2021.10.30.466617 — neuroscience — Posted on 2021-11-02
3782 Efficacy of longevity interventions in C. elegans is determined by early life activity of RNA splicing factors
Dutta, S.; Heintz, C.; Perez-Matos, M. C.; Mutlu, A. S.; Piper, M. E.; Mistry, M.; Sharma, A.; Smith, H. J.; Howell, P.; Sehgal, R.; Lanjuin, A.; Wang, M. C.; Mair, W. B.
10.1101/2021.11.01.466772 — genetics — Posted on 2021-11-02
3783 Statistical inference in population genomics
Johri, P.; Aquadro, C. F.; Beaumont, M.; Charlesworth, B.; Excoffier, L.; Eyre-Walker, A.; Keightley, P. D.; Lynch, M.; McVean, G.; Payseur, B. A.; Pfeifer, S. P.; Stephan, W.; Jensen, J. D.
10.1101/2021.10.27.466171 — evolutionary biology — Posted on 2021-11-02
3785 Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages
Bryan, A. M.; You, J. K.; Li, G.; Kim, J.; Singh, A.; Morstein, J.; Trauner, D.; Pereira de Sa, N.; Normile, T. G.; Farnoud, A. M.; London, E.; Del Poeta, M.
10.1101/2021.11.02.466923 — microbiology — Posted on 2021-11-02
3790 Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri
Shippy, T.; Miller, S.; Tamayo, B.; Hosmani, P. S.; Flores-Gonzalez, M.; Mueller, L. A.; Hunter, W. B.; Brown, S. J.; D'Elia, T.; Saha, S.
10.1101/2021.10.30.466601 — bioinformatics — Posted on 2021-11-02
3794 Separable mechanisms drive local and global polarity establishment in the C. elegans intestinal epithelium
Pickett, M. A.; Sallee, M. D.; Naturale, V. F.; Akpinaroglu, D.; Lee, J.; Shen, K.; Feldman, J.
10.1101/2021.11.01.466827 — cell biology — Posted on 2021-11-02
3795 Transcriptional regulation of cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation
Sautchuk, R.; Kalicharan, B. H.; Escalera-Rivera, K.; Jonason, J.; Porter, G.; Awad, H. A.; Eliseev, R. A.
10.1101/2021.11.01.466735 — cell biology — Posted on 2021-11-02
3798 An Immunogold Single Extracellular Vesicular RNA and Protein (AuSERP) Biochip to Predict Responses to Immunotherapy in Non-Small Cell Lung Cancer Patients
Nguyen, L. T. H.; Wang, X.; Kwak, K. J.; Zhang, J.; Okimoto, T.; Amann, J.; Rima, X. Y.; Yoon, M. J.; Shukuya, T.; Walters, N.; Ma, Y.; Belcher, D.; Li, H.; Palmer, A. F.; Carbone, D. P.; Lee, L. J.; Reategui, E.
10.1101/2021.10.30.466609 — immunology — Posted on 2021-11-02
3799 Btbd11 is an inhibitory interneuron specific synaptic scaffolding protein that supports excitatory synapse structure and function
Bygrave, A. M.; Sengupta, A.; Jackert, E. P.; Ahmed, M.; Adenuga, B.; Nelson, E.; Goldschmidt, H. L.; Johnson, R. C.; Zhong, H.; Yeh, F. L.; Sheng, M.; Huganir, R. L.
10.1101/2021.11.01.466782 — neuroscience — Posted on 2021-11-02
3805 DNA-free CRISPR-Cas9 gene editing of tetraploid tomatoes using protoplast regeneration
Hsu, C.-T.; Yuan, Y.-H.; Zheng, P.-X.; Wu, F.-H.; Cheng, Q.-W.; Wu, Y.-L.; Lin, S.; Yue, J.-J.; Cheng, Y.-H.; Lin, S.-I. L.; Shih, M.-C.; Sheen, J.; Lin, Y.-C.; Lin, C.-S.
10.1101/2021.11.02.466947 — plant biology — Posted on 2021-11-02
3806 Maize root-associated microbes likely under adaptive selection by the host to enhance phenotypic performance
Meier, M. A.; Xu, G.; Lopez-Guerrero, M. G.; Li, G.; Smith, C.; Sigmon, B.; Herr, J. R.; Alfano, J.; Ge, Y.; Schnable, J. C.; Yang, J.
10.1101/2021.11.01.466815 — plant biology — Posted on 2021-11-02
3807 The influence of unmeasured confounding on the MR Steiger approach
Lutz, S.; Voorhies, K.; Wu, A.; Hokanson, J.; Vansteelandt, S.; Lange, C.
10.1101/2021.10.28.466267 — genetics — Posted on 2021-11-02
3810 Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis
Chen, M.; Wang, J.; Yuan, M.; Long, M.; Wang, S.; Luo, W.; Huang, J.; Cheng, Y.; Zhang, W.; Jiang, W.; Chao, J.
10.1101/2021.11.01.466742 — cell biology — Posted on 2021-11-02
3811 Haspin participates in Aurora phosphorylation at centromeres and contributes to chromosome congression in male mouse meiosis
Berenguer, I.; Lopez Jimenez, P.; Mena, I.; Viera, A.; Page, J.; Maestre, C.; Malumbres, M.; Suja, J.; Gomez, R.
10.1101/2021.11.02.466959 — cell biology — Posted on 2021-11-02
3812 When Yeast Cells Change their Mind: Cell Cycle 'Start' is Reversible under Starvation
Irvali, D.; Schlottmann, F. P.; Muralidhara, P.; Nadelson, I.; Wood, N. E.; Doncic, A.; Ewald, J. C.
10.1101/2021.10.31.466668 — cell biology — Posted on 2021-11-02
3817 Genetic control of rhizosheath formation in pearl millet
de la Fuente Canto, C.; Diouf, M. N.; Ndour, P. M. S.; Debieu, M.; Grondin, A.; Passot, S.; Champion, A.; Barrachina, C.; Pratlong, M.; Gantet, P.; Assigbetse, K.; Kane, N.; Cubry, P.; Diedhiou, A. G.; Heulin, T.; Achouak, W.; Vigouroux, Y.; Cournac, L.; Laplaze, L.
10.1101/2021.11.02.466908 — plant biology — Posted on 2021-11-02
3820 A versatile mitochondria isolation- and analysis-pipeline generates 3D nano-topographies and mechano-physical surface maps of single organelles
Joshi, S.; Hater, F.; Eirich, J.; Palovaara, J.; Ellinghaus, H.; Heinkow, P.; Callenius, H.; Peter, A.; Schweser, O.; Kubitschke, M.; Madduri, M. K.; Mathew, A. J.; Ciacchi, L. C.; Kirstein, J.; Maedler, K.; Masseck, O. A.; Finkemeier, I.; Radmacher, M.; Gross-Hardt, R.
10.1101/2021.10.31.466655 — plant biology — Posted on 2021-11-02
3821 Bromodomains regulate dynamic targeting of the PBAF chromatin remodeling complex to chromatin hubs
Kenworthy, C. A.; Haque, N.; Liou, S.-H.; Chandris, P.; Wong, V.; Dziuba, P.; Lavis, L. D.; Liu, W.-L.; Singer, R. H.; Coleman, R. A.
10.1101/111674 — cell biology — Posted on 2021-11-02
3823 Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation
Joshi, P.; Chia, S.; Yang, X.; Perni, M.; Habchi, J.; Vendruscolo, M.
10.1101/2021.10.30.466561 — biophysics — Posted on 2021-11-02
3827 Development of a novel bioluminescent activity assay for peptide ligases
Zhang, C.-H.; Shao, X.-X.; Wang, X.-B.; Shou, L.-L.; Liu, Y.-L.; Xu, Z.-G.; Guo, Z.-Y.
10.1101/2021.11.01.466836 — biochemistry — Posted on 2021-11-02
3829 Transcriptional evaluation of the ductus arteriosus at the single-cell level uncovers a requirement for vimentin for complete closure
Salvador, J.; Hernandez, G. E.; Ma, F.; Abrahamson, C. W.; Goldman, R. D.; Pellegrini, M.; Ridge, K. M.; Iruela-Arispe, M. L.
10.1101/2021.10.30.466605 — developmental biology — Posted on 2021-11-02
3834 A novel mechanism of Euonymine inhibits in-stent restenosis through enhancing contractile phenotype of VSMCs by targeting AKT1 and p38MAPK
Zhang, L.; Tao, Y. T.; Hu, Q.; Yang, R. H.; Jia, J.; Jin, H. N.; Yang, Y. Z.; Yang, Y.; Yu, M. Y.; Wang, Y. T.; Shi, J. N.; Yu, D.; Tang, G. P.; Xu, J.; Xiong, B.; Shen, Z. Q.; Yu, Z.; Qin, H. T.; Chen, P.
10.1101/2021.10.29.466441 — pharmacology and toxicology — Posted on 2021-11-02
3835 Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution
Xiao, Y.; Jin, W.; Qian, K.; Wu, K.; Wang, G.; Jiang, W.; Cao, R.; Ju, L.; Zhao, Y.; Zheng, H.; Liu, T.; Chang, L.; Xu, Z.; Wang, T.; Luo, J.; Shan, L.; Yu, F.; Chen, X.; Liu, D.; Cao, H.; Yang, Z.; Li, S.; Shi, H.; Guo, Z.; Gong, Y.; Liu, N.; Li, S.; Wang, Y.; Cao, X.; Ding, W.; Zhou, W.; Cui, D.; Tian, Y.; Ji, C.; Luo, Y.; Hong, X.; Ma, H.; Chen, F.; Peng, M.; Zhang, Y.; Wang, X.
10.1101/2021.10.30.466556 — cancer biology — Posted on 2021-11-02
3839 Diversity, function and evolution of aquatic vertebrate genomes
Song, Y.; Yu, M.; Zhang, S.; Zhang, R.; Seim, I.; Guo, X.; Liu, M.; Yu, L.; Zhang, H.; Li, H.; Liu, S.; Liu, X.; Xu, X.; Yang, H.; Wang, K.; He, S.; Wang, W.; Fish10K Consortium, ; Fan, G.
10.1101/2021.10.29.466026 — genomics — Posted on 2021-11-02
3841 MutationalPatterns: The one stop shop for the analysis of mutational processes
Manders, F.; Brandsma, A. M.; de Kanter, J.; Verheul, M.; Oka, R.; van Roosmalen, M. J.; van der Roest, B.; van Hoeck, A.; Cuppen, E.; van Boxtel, R.
10.1101/2021.11.01.466730 — genomics — Posted on 2021-11-02
3843 Bimodal Remapping of Visual Grids
Long, X.; Cai, J.; Deng, B.; Chen, Z. S.; Zhang, S.-J.
10.1101/2021.10.30.466568 — neuroscience — Posted on 2021-11-02
3848 The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis
Dina Zita, M.; Phillips, M. B.; Stuart, J. D.; Kumarapeli, A. R.; Snyder, A. J.; Paredes, A.; Sridharan, V.; Boerma, M.; Danthi, P.; Boehme, K. W.
10.1101/2021.07.16.452757 — microbiology — Posted on 2021-11-02
3850 hECA: the cell-centric assembly of a cell atlas
Chen, S.; Luo, Y.; Gao, H.; Li, F.; Li, J.; Chen, Y.; You, R.; Hao, M.; Bian, H.; Xi, X.; Li, W.; Li, W.; Ye, M.; Meng, Q.; Zou, Z.; Li, C.; Li, H.; Zhang, Y.; Cui, Y.; Wei, L.; Chen, F.; Wang, X.; Lv, H.; Hua, K.; Jiang, R.; Zhang, X.
10.1101/2021.07.21.453289 — bioinformatics — Posted on 2021-11-02
3852 Removing Inter-Experimental Variability from Functional Data in Systems Neuroscience
Gonschorek, D.; Hoefling, L.; Szatko, K. P.; Franke, K.; Schubert, T.; Dunn, B.; Berens, P.; Klindt, D. A.; Euler, T.
10.1101/2021.10.29.466492 — neuroscience — Posted on 2021-11-02
3854 A database and comprehensive analysis of the algae genomes
Fan, G.; Shi, C.; Liu, X.; Han, K.; Peng, L.; Li, L.; Ge, Q.
10.1101/2021.10.30.466624 — genomics — Posted on 2021-11-02
3857 Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity
Perez-Schindler, J.; Vargas-Fernandez, E.; Karrer-Cardel, B.; Ritz, D.; Schmidt, A.; Handschin, C.
10.1101/2021.03.24.436772 — molecular biology — Posted on 2021-11-02
3859 A critical period of translational control during brain development at codon resolution
Harnett, D.; Ambrozkiewicz, M. C.; Zinnall, U.; Rusanova, A.; Borisova, E.; Dannenberg, R.; Imami, K.; Muenster-Wandowski, A.; Fauler, B.; Mielke, T.; Selbach, M.; Landthaler, M.; Spahn, C. M. T.; Tarabykin, V.; Ohler, U.; Kraushar, M. L.
10.1101/2021.06.23.449626 — neuroscience — Posted on 2021-11-02
3861 Inhibition of SAR S-CoV-2 infection and replication by lactoferrin, MUC1 and α-lactalbumin identified in human breastmilk
Xiang, K.; Lai, X.; Yu, Y.; Xian, W.; Ye, F.; Ju, X.; Luo, Y.; Dong, H.; Zhou, Y.; Tan, W.; Zhuang, H.; Li, T.; Liu, X.; Ding, Q.
10.1101/2021.10.29.466402 — microbiology — Posted on 2021-11-02
3862 Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
Park, B.-y.; Kebets, V.; Lariviere, S.; Hettwer, M. D.; Paquola, C.; van Rooij, D.; Buitelaar, J.; Franke, B.; Hoogman, M.; Schmaal, L.; Veltman, D. J.; van den Heuvel, O.; Stein, D. J.; Andreassen, O. A.; Ching, C. R. K.; Turner, J.; van Erp, T. G. M.; Evans, A. C.; Dagher, A.; Thomopoulos, S. I.; Thompson, P. M.; Valk, S. L.; Kirschner, M.; Bernhardt, B. C.
10.1101/2021.10.29.466434 — neuroscience — Posted on 2021-11-02
3864 EEG microstate dynamics indicate a U-shaped path to propofol-induced loss of consciousness
Artoni, F.; Maillard, J.; Britz, J.; Seeber, M.; Lysakowski, C.; Brechet, L.; Tramer, M. R.; Michel, C. M.
10.1101/2021.10.26.465841 — neuroscience — Posted on 2021-11-02
3866 Flexible circuit mechanisms for context-dependent song sequencing
Roemschied, F. A.; Pacheco Pinedo, D. A.; Ireland, E. C.; Li, X.; Aragon, M. J.; Pang, R. K.; Murthy, M.
10.1101/2021.11.01.466727 — neuroscience — Posted on 2021-11-02
3868 Microbiome restructuring: dominant coral bacterium Endozoicomonas species display differential adaptive capabilities to environmental changes
Tandon, K.; Chiou, Y.-J.; Yu, S.-P.; Hsieh, H. J.; Lu, C.-Y.; Hsu, M.-T.; Chiang, P.-W.; Chen, H.-J.; Wada, N.; Tang, S.-L.
10.1101/2021.10.31.466697 — microbiology — Posted on 2021-11-01
3870 A metagenomic analysis of the wrackbed microbiome indicates a phylogeographic break along the North Sea - Baltic Sea transition zone
Berdan, E.; Roger, F.; Kinnby, A.; Cervin, G.; Pereyra, R.; Topel, M.; Wellenreuther, M.; Johannesson, K.; Butlin, R. K.; Andre, C.
10.1101/2021.11.01.466799 — genomics — Posted on 2021-11-01
3871 Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara express-ing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells
Yang, N.; Wang, Y.; Liu, S.; Luna, J. M.; Mazo, G.; Tan, A. Y.; Zhang, T.; Wang, J.; Yan, W.; Choi, J.; Rossi, A.; Xiang, J. Z.; Rice, C. M.; Merghoub, T.; Wolchok, J. D.; Deng, L.
10.1101/2021.10.31.466698 — immunology — Posted on 2021-11-01
3873 Nuclear activation in dual-durotaxing cells on a matrix with cell-scale stiffness-heterogeneity
Kidoaki, S.; Ebata, H.; Moriyama, K.; Kuboki, T.; Tsuji, Y.; Sawada, R.; Sasaki, S.; Okuda, T.; Hamano, K.; Kawano, T.; Yamamoto, A.; Kono, K.; Tanaka, K.
10.1101/2021.10.30.466554 — biophysics — Posted on 2021-11-01
3875 A new gene family diagnostic for intracellular biomineralization of amorphous Ca-carbonates by cyanobacteria
Benzerara, K.; Duprat, E.; Bitard-Feildel, T.; Caumes, G.; Cassier-Chauvat, C.; Chauvat, F.; Dezi, M.; Diop Seydina, I.; Gaschignard, G.; Görgen, S.; Gugger, M.; Lopez-Garcia, P.; Skouri-Panet, F.; Moreira, D.; Callebaut, I.
10.1101/2021.11.01.465933 — evolutionary biology — Posted on 2021-11-01
3878 An essential ER-resident N-acetyltransferase in Plasmodium falciparum
Polino, A. J.; Floyd, K.; Avila-Cruz, Y.; Yang, Y.; Goldberg, D. E.
10.1101/2021.11.01.466802 — microbiology — Posted on 2021-11-01
3880 Bacterial growth in multicellular aggregates leads to the emergence of complex lifecycles
Schwartzman, J. A.; Ebrahimi, A.; Chadwick, G.; Sato, Y.; Orphan, V.; Cordero, O. X.
10.1101/2021.11.01.466752 — microbiology — Posted on 2021-11-01
3881 Black-necked spitting cobra (Naja nigricollis) phospholipases A2 cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket
Martos-Esteban, A.; Macleod, O. J. S.; Maudlin, I.; Kalogeropoulos, K.; Jurgensen, J. A.; Carrington, M.; Laustsen, A. H.
10.1101/2021.11.01.466813 — microbiology — Posted on 2021-11-01
3883 SARS-CoV-2 mechanistic correlates of protection: insight from modelling response to vaccines
Alexandre, M.; Marlin, R.; Prague, M.; Severin, C.; Kahlaoui, N.; Cardinaud, S.; Naninck, T.; Delache, B.; Surenaud, M.; Galhaut, M.; Dereuddre-Bosquet, N.; Cavarelli, M.; Maisonnasse, P.; Centlivre, M.; Lacabaratz, C.; Wiedemann, A.; Zurawski, S.; Zurawski, G.; Schwartz, O.; Sanders, R. W.; Le Grand, R.; Levy, Y.; Thiebaut, R.
10.1101/2021.10.29.466418 — immunology — Posted on 2021-11-01
3885 Parallel functional subnetworks embedded in the macaque face patch system
Park, S. H.; Koyano, K. W.; Russ, B. E.; Waidmann, E. N.; McMahon, D. B. T.; Leopold, D. A.
10.1101/2021.10.25.465775 — neuroscience — Posted on 2021-11-01
3886 Variations in EEG predict the individual differences in social tasks
Zhang, H.; Zhang, K.; Zhang, Z.; Zhao, M.; Liu, Q.; Luo, W.; Wu, H.
10.1101/2021.10.29.465647 — neuroscience — Posted on 2021-11-01
3889 Improving the Virtual Trichrome Assessment through Bridge Category Models
Levy, J.; Bobak, C. A.; Azizgolshani, N.; Liu, X.; Ren, B.; Lisovsky, M.; Suriawinata, A. A.; Christensen, B.; O'Malley, J.; Vaickus, L. J.
10.1101/2021.10.30.466613 — pathology — Posted on 2021-11-01
3890 Air plasma-activated medium exerts tumor-specific cytotoxicity via the oxidative stress-induced perinuclear mitochondrial clustering
Suzuki-Karasaki, M.; Ando, T.; Ochiai, Y.; Kawahara, K.; Suzuki-Karasaki, M.; Nakayama, H.; Suzuki-Karasaki, Y.
10.1101/2021.10.31.466636 — cancer biology — Posted on 2021-11-01
3891 The landscape of extrachromosomal circular DNA in medulloblastoma
Chapman, O. S.; Luebeck, J.; Wani, S.; Tiwari, A.; Pagadala, M.; Wang, S.; Larson, J. D.; Lange, J. T.; Wong, I. T.-L.; Dehkordi, S. R.; Chandran, S.; Adam, M.; Lin, Y.; Juarez, E.; Robinson, J. T.; Sridhar, S.; Malicki, D. M.; Coufal, N.; Levy, M.; Crawford, J. R.; Pomeroy, S. L.; Rich, J.; Scheuermann, R.; Carter, H.; Dixon, J.; Mischel, P. S.; Fraenkel, E.; Wechsler-Reya, R. J.; Bafna, V.; Mesirov, J. P.; Chavez, L.
10.1101/2021.10.18.464907 — cancer biology — Posted on 2021-11-01
3892 Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases
Ioannidi, E. I.; Yarnall, M. T. N.; Schmitt-Ulms, C.; Krajeski, R. N.; Lim, J.; Villiger, L.; Zhou, W.; Jiang, K.; Roberts, N.; Zhang, L.; Vakulskas, C. A.; Walker, J. A.; Kadina, A. P.; Zepeda, A. E.; Holden, K.; Gootenberg, J. S.; Abudayyeh, O. O.
10.1101/2021.11.01.466786 — bioengineering — Posted on 2021-11-01
3895 Spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis
Lefrancq, N.; Bouchez, V.; Fernandes, N.; Barkoff, A.-M.; Bosch, T.; Dalby, T.; Akerlund, T.; Fabianova, K.; Vestrheim, D. F.; Fry, N. K.; Gonzalez-Lopez, J. J.; Gullsby, K.; Habington, A.; He, Q.; Litt, D.; Martini, H.; Pierard, D.; Stefanelli, P.; Stegger, M. K.; Zavadilov, J.; Armatys, N.; Landier, A.; Guillot, S.; Hong, S. L.; Lemey, P.; Parkhill, J.; Toubiana, J.; Cauchemez, S.; Salje, H.; Brisse, S.
10.1101/2021.11.01.466439 — genetics — Posted on 2021-11-01
3900 Multiple spillovers and onward transmission of SARS-Cov-2 in free-living and captive White-tailed deer (Odocoileus virginianus)
Kuchipudi, S. V.; Surendran-Nair, M.; Ruden, R. M.; Yon, M.; Nissly, R. H.; Nelli, R. K.; Li, L.; Jayarao, B. M.; Vandegrift, K.; Maranas, C. D.; Levine, N.; Willgert, K.; Conlan, A. J. K.; Olsen, R. J.; Davis, J.; Musser, J. M.; Hudson, P. J.; Kapur, V.
10.1101/2021.10.31.466677 — microbiology — Posted on 2021-11-01
3902 Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in PSC.
Awoniyi, M.; Wang, J.; Ngo, B.; Meadows, V.; Tam, J.; Viswanathan, A.; Lai, Y.; Montgomery, S.; Farmer, M.; Kummen, M.; Thingholm, L. B.; Schramm, C.; Bang, C.; Franke, A.; Schnabl, B.; Lu, K.; Ting, J. P.; Popov, Y. V.; Hov, J. R.; Francis, H.; Sartor, R. B.
10.1101/2021.10.31.466701 — microbiology — Posted on 2021-11-01
3903 Yersinia pseudotuberculosis doxycycline tolerance strategies include modulating expression of genes involved in cell permeability and tRNA modifications
Alvarez-Manzo, H. S.; Davidson, R. K.; Van Cauwelaert de Wyels, J.; Cotten, K. L.; Nguyen, B.; Zhu, Z.; Anthony, J.; van Opijnen, T.; Davis, K. M.
10.1101/2021.11.01.466809 — microbiology — Posted on 2021-11-01
3906 An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses
Ye, S.; Lu, C.; Qiu, Y.; Zheng, H.; Ge, X.; Wu, A.; Xia, Z.; Jiang, T.; Zhu, H.; Peng, Y.
10.1101/2021.11.01.466721 — microbiology — Posted on 2021-11-01
3907 The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation
Arumugam, P.; Chauhan, M.; Rajeev, T.; Chakraborty, R.; Shankaran, D.; Ramalingam, S.; Gandotra, S.; Rao, V. K.
10.1101/2021.11.01.466732 — immunology — Posted on 2021-11-01
3910 Visceral Fat Inflammation and Fat Embolism are associated with Lung's Lipidic Hyaline Membranes in COVID-19 patients
Colleluori, G.; Graciotti, L.; Pesaresi, M.; Di Vincenzo, A.; Perugini, J.; Di Mercurio, E.; Caucci, S.; Bagnarelli, P.; Zingaretti, C. M.; Nisoli, E.; Menzo, S.; Tagliabracci, A.; Ladoux, A.; Dani, C.; Giordano, A.; Cinti, S.
10.1101/2021.10.30.466586 — pathology — Posted on 2021-11-01
3911 Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition
Karthaus, W.; Chan, J.; Setty, M.; Love, J.; Zaidi, S.; Choo, Z.-N.; Persad, S.; LaClair, J.; Lawrence, K.; Chaudhary, O.; Xu, T.; Masilionis, I.; Mazutis, L.; Chaligne, R.; Pe'er, D.; Sawyers, C.
10.1101/2021.11.01.466615 — cancer biology — Posted on 2021-11-01
3914 Mouse Organ Specific Proteins and Functions
Sun, B.; Lorang, C.; Zhang, Y.; Liu, K.; Sun, Z.; Utleg, A.; Hu, Z.; Wang, K.; Moritz, R.; Hood, L.
10.1101/2021.11.01.466788 — genomics — Posted on 2021-11-01
3917 Vagus nerve stimulation accelerates motor learning through cholinergic modulation
Bowles, S.; Hickman, J.; Peng, X.; Williamson, W. R.; Huang, R.; Washington, K.; Donegan, D.; Welle, C.
10.1101/2021.10.28.466306 — neuroscience — Posted on 2021-11-01
3920 Multiscale mechanistic modelling of the host defense in invasiveaspergillosis reveals leukocyte activation and iron acquisition as driversof infection outcome
Ribeiro, H. A.; Sordo Vieira, L.; Scindia, Y.; Adhikari, B.; Wheeler, M.; Knapp, A.; Schroeder, W.; Mehrad, B.; Laubenbacher, R.
10.1101/2021.06.08.447590 — systems biology — Posted on 2021-11-01
3923 Identification of microRNAs that stabilize p53 in HPV-positive cancer cells
Martinez-Noël, G.; Szajner, P.; Kramer, R. E.; Boyland, K.; Sheikh, A.; Smith, J. A.; Howley, P. M.
10.1101/2020.09.21.305946 — cancer biology — Posted on 2021-11-01
3925 RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine
Wood, E. C.; Glen, A. K.; Kvarfordt, L. G.; Womack, F.; Acevedo, L.; Yoon, T. S.; Ma, C.; Flores, V.; Sinha, M.; Chodpathumwan, Y.; Termehchy, A.; Roach, J. C.; Mendoza, L.; Hoffman, A. S.; Deutsch, E. W.; Koslicki, D.; Ramsey, S. A.
10.1101/2021.10.17.464747 — bioinformatics — Posted on 2021-11-01
3930 Serial invasions can disrupt the time course of ecosystem recovery
Karatayev, V. A.; Rudstam, L. G.; Karatayev, A. Y.; Burlakova, L. E.; Adamovich, B. V.; Zhukava, H. A.; Holeck, K. T.; Hetherington, A. L.; Jackson, J. R.; Hotaling, C. W.; Zhukova, T. V.; Mikheyeva, T. M.; Kovalevskaya, R. Z.; Makarevich, O. A.; Kruk, D. V.
10.1101/2021.10.29.466526 — ecology — Posted on 2021-11-01
3931 Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L
Yu, F.; Pan, T.; Huang, F.; Ying, R.; Liu, J.; Fan, H.; Zhang, J.; Liu, W.; Lin, Y.; Yuan, Y.; Yang, T.; Li, R.; Zhang, X.; Lv, X.; Chen, Q.; Liang, A.; Zou, F.; Liu, B.; Hu, F.; Tang, X.; Li, L.; Deng, K.; He, X.; Zhang, H.; Zhang, Y.; Ma, X.
10.1101/2020.02.05.935387 — microbiology — Posted on 2021-11-01
3932 Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike
Lubinski, B.; Fernandes, M. H.; Frazier, L.; Tang, T.; Daniel, S.; Diel, D.; Jaimes, J. A.; Whittaker, G.
10.1101/2021.04.06.438731 — microbiology — Posted on 2021-11-01
3934 Tracking neural activity from the same cells during the entire adult life of mice
Zhao, S.; Tang, X.; Partarrieu, S.; Guo, S.; Liu, R.; Lee, J.; Lin, Z.; Liu, J.
10.1101/2021.10.29.466524 — neuroscience — Posted on 2021-11-01
3935 Selective Control of Synaptically-Connected Circuit Elements by All-Optical Synapses
Prakash, M.; Murphy, J.; St Laurent, R.; Friedman, N.; Crespo, E.; Bjorefeldt, A.; Pal, A.; Bhagat, Y.; Kauer, J. A.; Shaner, N.; Lipscombe, D.; Moore, C.; Hochgeschwender, U.
10.1101/2021.10.29.466531 — neuroscience — Posted on 2021-11-01
3936 Conserved and newly acquired roles of PIF1 homologs in tomato (Solanum lycopersicum)
SIMON-MOYA, M.; BARJA, M. V.; MORELLI, L.; ROSADO, D.; QI, L.; DIRETTO, G.; MATUS, T.; LLORENTE, B.; MARTINEZ-GARCIA, J. F.; GOOSSENS, A.; ROSSI, M. M.; RODRIGUEZ-CONCEPCION, M.
10.1101/2021.10.29.466498 — plant biology — Posted on 2021-11-01
3940 Dry Powders for Inhalation Containing Monoclonal Antibodies Made by Thin-Film Freeze-Drying
Hufnagel, S.; Xu, H.; Sahakijpijarn, S.; Moon, C.; Chow, L. Q. M.; Williams, R. O.; Cui, Z.
10.1101/2021.10.29.466456 — pharmacology and toxicology — Posted on 2021-11-01
3941 Improving mathematical models of cancer by including resistance to therapy: a study in non-small cell lung cancer
Ardevol Martinez, V.; Ghaffari Laleh, N.; Salvioli, M.; Thuijsman, F.; Brown, J. S.; Cavill, R.; Kather, J. N.; Stankova, K.
10.1101/2021.10.29.466444 — cancer biology — Posted on 2021-11-01
3942 Allosteric modulation of the SARS-CoV-2 spike conformation
Diaz-Salinas, M. A.; Li, Q.; Ejemel, M.; Wang, Y.; Munro, J. B.
10.1101/2021.10.29.466470 — biophysics — Posted on 2021-11-01
3944 Blood pressure and the kidney cortex transcriptome response to high sodium diet challenge in female nonhuman primates
Riojas, A. M.; Spradling-Reeves, K. D.; Shade, R. E.; Puppala, S. R.; Christensen, C. L.; Birnbaum, S.; Glenn, J. P.; Li, C.; Shaltout, H.; Hall-Ursone, S.; Cox, L. A.
10.1101/2021.10.29.466291 — genomics — Posted on 2021-11-01
3946 SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
Samsudin, F.; Raghuvamsi, P.; Petruk, G.; Puthia, M.; Petrlova, J.; MacAry, P.; Anand, G. S.; Schmidtchen, A.; Bond, P. J.
10.1101/2021.10.29.466401 — microbiology — Posted on 2021-11-01
3947 mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain
Chen, L.; Hu, Y.; Wang, S.; Cao, K.; Mai, W.; Sha, W.; Huan, M.; Gao, Y.; Duan, S.; Wang, Y.; Gao, Z.
10.1101/2021.10.29.466458 — neuroscience — Posted on 2021-11-01
3949 Decoding grasp and speech signals from the cortical grasp circuit in a tetraplegic human
Wandelt, S. K.; Kellis, S.; Bjanes, D.; Pejsa, K.; Lee, B.; Liu, C.; Andersen, R. A.
10.1101/2021.10.29.466528 — neuroscience — Posted on 2021-11-01
3950 Fragmented Spatial Maps: State Abstraction and Efficient Planning from Surprisal
Klukas, M.; Sharma, S.; Du, Y.; Lozano-Perez, T.; Kaelbling, L. P.; Fiete, I.
10.1101/2021.10.29.466499 — neuroscience — Posted on 2021-11-01
3955 Oral Lichen Planus and its relation with Oral Squamous Cell Carcinoma: new insights into the potential for malignant transformation
de Lanna, C. A.; Monteiro da Silva, B. N.; de Melo, A. C.; Bonamino, M. H.; Alves, L. D. B.; Ribeiro Pinto, L. F.; Cardoso, A. S.; Antunes, H. S.; Boroni, M.; Goldemberg, D. C.
10.1101/2021.10.29.466364 — bioinformatics — Posted on 2021-11-01
3956 Epigenomic and transcriptomic prioritization of candidate obesity-risk regulatory GWAS SNPs
Zhang, X.; Li, T.; Xiao, H.-M.; Ehrlich, K. C.; Shen, H.; Deng, H.-W.; Ehrlich, M.
10.1101/2021.10.29.466522 — bioinformatics — Posted on 2021-11-01
3957 Sex and Estrous Cycle in Memory for Sequences of Events in Rats
Jayachandran, M.; Langius, P.; Pazos Rego, F.; Vertes, R. P.; Allen, T. A.
10.1101/2021.10.29.466512 — animal behavior and cognition — Posted on 2021-11-01
3959 Age-related response speed deficits arise from specific impairments in sensory evidence accumulation rate
Brosnan, M. B.; O'Neill, M. H.; Loughnane, G. M.; Pearce, D. J.; Fleming, B.; Chong, T. T. J.; Nobre, A. C.; O'Connell, R. G.; Bellgrove, M. A.
10.1101/2021.10.28.466233 — neuroscience — Posted on 2021-11-01
3966 Removing Inter-Experimental Variability from Functional Data in Systems Neuroscience
Gonschorek, D.; Hoefling, L.; Szatko, K. P.; Franke, K.; Schubert, T.; Dunn, B.; Berens, P.; Klindt, D. A.; Euler, T.
10.1101/2021.10.29.466492 — neuroscience — Posted on 2021-11-01
3968 Essential elements of radical pair magnetosensitivity in Drosophila
Bradlaugh, A.; Fedele, G.; Munro, A.; Hansen, C.; Kyriacou, C.; Jones, A. R.; Rosato, E.; Baines, R.
10.1101/2021.10.29.466426 — physiology — Posted on 2021-11-01
3970 Particle interactions and their effect on magnetic particle imaging and spectroscopy
Moor, L.; Scheibler, S.; Gerken, L.; Scheffler, K.; Thieben, F.; Knopp, T.; Herrmann, I.; Starsich, F. H. L.
10.1101/2021.10.29.466424 — bioengineering — Posted on 2021-11-01
3972 Anisotropic interaction and motion states of locusts in a hopper band
Weinburd, J.; Landsberg, J.; Kravtsova, A.; Lam, S.; Sharma, T.; Simpson, S. J.; Sword, G. A.; Buhl, J.
10.1101/2021.10.29.466390 — animal behavior and cognition — Posted on 2021-11-01
3973 Identifying Lethal Dependencies with HUGE Predictive Power from Large-Scale Functional Genomic Screens
Carazo, F.; San Jose Eneriz, E.; Gimeno, M.; Garate, L.; Miranda, E.; Castilla, C.; Agirre, X.; Rubio, A.; Prosper, F.
10.1101/2021.10.29.466419 — genomics — Posted on 2021-11-01
3976 Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication
Ogando, N. S.; El Kazzi, P.; Zevenhoven-Dobbe, J. C.; Bontes, B. w.; Decombe, A.; Posthuma, C. C. S.; Thiel, V.; Canard, B.; Ferron, F.; Decroly, E.; Snijder, E. J.
10.1101/2021.05.17.444407 — molecular biology — Posted on 2021-11-01
3978 A retrograde mechanism coordinates memory allocation across brain regions
Lavi, A.; Sehgal, M.; Sisan, F.; Okabe, A.; Ter-Mkrtchyan, D.; Silva, A. J.
10.1101/2021.10.28.466361 — neuroscience — Posted on 2021-11-01
3979 Co-allocation to overlapping dendritic branches in the retrosplenial cortex integrates contextual memories across time
Sehgal, M.; Almeida-Filho, D.; Martin, S.; Mejia, I. D.; Kastellakis, G.; Kim, S.; Lee, J.; Pekcan, A.; Huang, S.; Lavi, A.; Heo, W. D.; Poirazi, P.; Trachtenberg, J. T.; Silva, A. J.
10.1101/2021.10.28.466343 — neuroscience — Posted on 2021-11-01
3982 Variations in EEG predicts the individual differences in social tasks
Zhang, H.; Zhang, K.; Zhang, Z.; Zhao, M.; Liu, Q.; Luo, W.; Wu, H.
10.1101/2021.10.29.465647 — neuroscience — Posted on 2021-11-01
3983 Biological Insights Knowledge Graph: an integrated knowledge graph to support drug development
Geleta, D.; Nikolov, A.; Edwards, G.; Gogleva, A.; Jackson, R.; Jansson, E.; Lamov, A.; Nilsson, S.; Pettersson, M.; Poroshin, V.; Rozemberczki, B.; Scrivener, T.; Ughetto, M.; Papa, E.
10.1101/2021.10.28.466262 — systems biology — Posted on 2021-11-01
3987 Whole genome sequencing and the application of a SNP panel reveal primary evolutionary lineages and genomic diversity in the lion (Panthera leo)
Bertola, L. D.; Vermaat, M.; Lesilau, F.; Chege, M.; Tumenta, P. N.; Sogbohossou, E. A.; Schaap, O. D.; Bauer, H.; Patterson, B. D.; White, P. A.; de Iongh, H. H.; Laros, J. F.; Vrieling, K.
10.1101/814103 — evolutionary biology — Posted on 2021-11-01
3990 EEG biomarkers of free recall
Katerman, B. S.; Li, Y.; Pazdera, J. K.; Keane, C.; Kahana, M. J.
10.1101/2021.04.30.442192 — neuroscience — Posted on 2021-11-01
3992 Quantitative analysis of ZFY and CTCF reveals dependent recognition of tandem zinc finger proteins.
Zuo, Z.; Billings, T.; Walker, M.; Petkov, P. M.; Stormo, G. D.; Fordyce, P. M.
10.1101/637298 — genetics — Posted on 2021-11-01
3993 Coordinate regulation of liver ferroportin degradation and de novo synthesis determines serum iron levels in mice
Charlebois, E.; Fillebeen, C.; Katsarou, A.; Rabinovich, A.; Wisniewski, K.; Venkataramani, V.; Michalke, B.; Velentza, A.; Pantopulos, K.
10.1101/2021.10.29.466457 — immunology — Posted on 2021-11-01
3994 Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms
Hesgrove, C. S.; Nguyen, K. H.; Biswas, S.; Childs, C. A.; KC, S.; Medina, B. X.; Alvarado, V.; Sukenik, S.; Yu, F.; Malferrari, M.; Francia, F.; Venturoli, G.; Martin, E. W.; Holehouse, A. S.; Boothby, T. C.
10.1101/2021.08.16.456555 — biophysics — Posted on 2021-11-01
3995 Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes.
Seyres, D.; Cabassi, A.; Lambourne, J. J.; Burden, F.; Farrow, S.; McKinney, H.; Batista, J.; Kempster, C.; Pietzner, M.; Slingsby, O.; Cao, T. H.; Quinn, P.; Stefanucci, L.; Sims, M. C.; Rehnstrom, K.; Adams, C.; Frary, A.; Erguener, B.; Kreuzhuber, R.; Mocciaro, G.; Allison, M.; D'Amore, S.; Koulman, A.; Grassi, L.; Griffin, J. L.; Ng, L. L.; Park, A.; Savage, D. B.; Langenberg, C.; Wareham, N. J.; Allison, M.; Bock, C.; Downes, K.; Vacca, M.; Kirk, P. D.; Frontini, M.
10.1101/2020.03.06.961805 — genomics — Posted on 2021-11-01
4004 Selective Vulnerability of Tripartite Synapses in Amyotrophic Lateral Sclerosis.
Broadhead, M. J.; Bonthron, C.; Waddington, J.; Smith, W. V.; Lopez, M. F.; Burley, S.; Valli, J.; Zhu, F.; Komiyama, N. H.; Smith, C.; Grant, S. G.; Miles, G. B.
10.1101/2021.10.28.465435 — neuroscience — Posted on 2021-11-01
4005 Computational and neural mechanisms of affected beliefs
Müller-Pinzler, L.; Czekalla, N.; Mayer, A. V.; Schröder, A.; Stolz, D. S.; Paulus, F. M.; Krach, S.
10.1101/2021.10.26.465922 — neuroscience — Posted on 2021-11-01
4007 Deficiency of p38α-MAPK in myeloid cells ameliorates symptoms and pathology of APP-transgenic Alzheimer's disease mice
Luo, Q.; Schnöder, L.; Hao, W.; Litzenburger, K.; Decker, Y.; Tomic, I.; Menger, M.; Fassbender, K.; Liu, Y.
10.1101/2021.10.18.464870 — neuroscience — Posted on 2021-11-01
4008 Regulatory start-stop elements in 5' untranslated regions pervasively modulate translation
Rendleman, J.; Mohammad, M. P.; Pressler, M.; Maity, S.; Hronova, V.; Gao, Z.; Herrmannova, A.; Lei, A.; Allgoewer, K.; Sultanov, D.; Hinckley, W. E.; Szkop, K.; Topisirovic, I.; Larsson, O.; Hatzoglou, M.; Valasek, L. S.; Vogel, C.
10.1101/2021.07.26.453809 — systems biology — Posted on 2021-11-01
4009 A mitochondrial mutational signature of temperature in ectothermic and endothermicvertebrates.
Mikhailova, A. G.; Iliushchenko, D.; Shamanskiy, V.; Mihailova, A. A.; Ushakova, K.; Tretiakov, E.; Oreshkov, S.; Knorre, D.; Polishchuk, L.; Lawless, D.; Kuzmin, A.; Denisov, S.; Kozenkov, I.; Mazunin, I.; Kunz, W.; Tanaka, M.; Makeev, V.; Castilho, R.; Yurov, V.; Kuptsov, A.; Fellay, J. S.; Khrapko, K.; Gunbin, K.; Popadin, K.
10.1101/2020.07.25.221184 — evolutionary biology — Posted on 2021-11-01
4010 Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture
Tirumala, N. A.; Redpath, G. M. I.; Kapoor-Kaushik, N.; Ariotti, N.; Dolai, P.; Kumar, K. V.; Ananthanarayanan, V.
10.1101/2021.04.05.438428 — cell biology — Posted on 2021-11-01