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Archive, 2022-06

2 Pick-up Single-Cell Proteomic Analysis for Quantifying up to 3000 Proteins in a Tumor Cell
Wang, Y.; Guan, Z.-Y.; Shi, S.-W.; Jiang, Y.-R.; Wu, Q.; Wu, J.; Chen, J.-B.; Ying, W.-X.; Xu, Q.-Q.; Fan, Q.-X.; Wang, H.-F.; Zhou, L.; Pan, J.-Z.; Fang, Q.
10.1101/2022.06.28.498038 — cancer biology — Posted on 2022-06-30
5 Nonlinear effect of light intensity on normal axial development of rhesus monkeys
Hu, Y.; Yang, H.; Wu, J.; Li, H.; Lv, L.; Zhu, Z.; Zhou, L.; Zhang, Y.; Yan, F.; Fan, S.; Li, C.; Wang, S.; Zhao, J.; Qi, Q.; Huang, C.; Hu, X.
10.1101/2022.06.28.497947 — developmental biology — Posted on 2022-06-30
9 Scanning ion-conductance microscopy for studying β-amyloid aggregate formation on living cell surface
Kolmogorov, V.; Erofeev, A.; Barykin, E.; Timoshenko, R.; Lopatukhina, E.; Kozin, S.; Salikhov, S.; Klyachko, N.; Mitkevich, V.; Edwards, C.; Korchev, Y.; Makarov, A.; Gorelkin, P.
10.1101/2022.06.30.498242 — cell biology — Posted on 2022-06-30
11 Accurate and efficient protein sequence designthrough learning concise local environment of residues
Huang, B.; Fan, T.; Wang, K.; Zhang, H.; Yu, C.; Nie, S.; Qi, Y.; Zheng, W.-M.; Han, J.; Fan, Z.; Sun, S.; Ye, S.; Yang, H.; Bu, D.
10.1101/2022.06.25.497605 — bioinformatics — Posted on 2022-06-30
13 A flexible electronic strain sensor for the real-time monitoring of tumor regression
Abramson, A.; Chan, C.; Khan, Y.; Mermin-Bunnell, A.; Matsuhisa, N.; Fong, R.; Shad, R.; Hiesinger, W.; Mallick, P.; Gambhir, S. S.; Bao, Z.
10.1101/2021.09.16.460551 — bioengineering — Posted on 2022-06-30
17 Small cytosolic dsDNAs repress cGAS activation and induce autophagy
Liu, Y.; Chen, X.; Zhao, Y.; Wang, X.; Chen, L.; Wang, W.; Zhong, S.; Hu, M.; Dai, Z.; Jiang, J.; Cheng, X.; Zuo, J.; Liu, H.; Ma, D.; Wang, X.; Ji, H.; Hu, S.; Luo, Y.-W.; Huang, A.; Tang, K.-F.
10.1101/2022.06.30.498186 — molecular biology — Posted on 2022-06-30
18 Diversity and composition of methanotroph communities in caves
Webster, K. D.; Schimmelmann, A.; Drobniak, A.; Mastalerz, M.; Rosales Lagarde, L.; Boston, P. J.; Lennon, J. T.
10.1101/412213 — microbiology — Posted on 2022-06-30
21 Disruption of lactate metabolism in the peripheral nervous system leads to motor-selective deficits
Bloom, J.; Hackett, A.; Strickland, A.; Yamada, Y.; Ippolito, J. E.; Schmidt, R. E.; Sasaki, Y.; DiAntonio, A.; Milbrandt, J.
10.1101/2022.06.29.497865 — neuroscience — Posted on 2022-06-30
24 FiNN: A toolbox for neurophysiological network analysis
Scherer, M.; Wang, T.; Guggenberger, R.; Milosevic, L.; Gharabaghi, A.
10.1101/2022.02.11.479403 — neuroscience — Posted on 2022-06-30
26 Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins
Healy, M. D.; Sacharz, J.; McNally, K. E.; McConville, C.; Tillu, V.; Hall, R. J.; Chilton, M.; Cullen, P. J.; Mobli, M.; Ghai, R.; Stroud, D. A.; Collins, B.
10.1101/2021.07.29.454387 — biochemistry — Posted on 2022-06-30
27 Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains
Hodgins, H. P.; Chen, P.; Lobb, B.; Tremblay, B. J.; Mansfield, M. J.; Lee, V. C.; Lee, P.-G.; Coffin, J.; Wei, X.; Duggan, A. T.; Dolphin, A. E.; Renaud, G.; Dong, M.; Doxey, A. C.
10.1101/2022.06.30.498301 — genomics — Posted on 2022-06-30
29 Genome assembly and association tests identify interacting loci associated with vigor, precocity, and sex in interspecific pistachio rootstocks
Palmer, W.; Jacygrad, E.; Sagayaradj, S.; Cavanaugh, K.; Han, R.; Bertier, L.; Beede, B.; Kafkas, S.; Golino, D.; Preece, J.; Michelmore, R. W.
10.1101/2022.06.28.498047 — genetics — Posted on 2022-06-30
33 BOLD cofluctuation 'events' are predicted from static functional connectivity
Ladwig, Z.; Seitzman, B. A.; Dworetsky, A.; Yu, Y.; Adeyemo, B.; Smith, D. M.; Petersen, S. E.; Gratton, C.
10.1101/2022.01.24.477543 — neuroscience — Posted on 2022-06-30
34 Decoding natural astrocyte rhythms: dynamic actin waves result from environmental sensing by primary rodent astrocytes
O'Neill, K. M.; Saracino, E.; Barile, B.; Mennona, N. J.; Mola, M. G.; Pathak, S.; Posati, T.; Zamboni, R.; Nicchia, G. P.; Benfenati, V.; Losert, W.
10.1101/2021.09.13.460152 — neuroscience — Posted on 2022-06-30
36 Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell disease
Metaferia, B.; Cellmer, T.; Dunkerlberger, E. B.; Li, Q.; Henry, E. R.; Hofrichter, J.; Staton, D.; Hsieh, M. M.; Conrey, A. K.; Tisdale, J. F.; Chatterjee, A. K.; Thein, S. L.; Eaton, W. A.
10.1101/2022.06.23.497377 — pharmacology and toxicology — Posted on 2022-06-30
37 From Molecular Dynamics to Supramolecular Organization: The Role of PIM Lipids in the Originality of the Mycobacterial Plasma Membrane
Brown, C. M.; Corey, R. A.; Gao, Y.; Choi, Y. K.; Gilleron, M.; Destainville, N.; Fullam, E.; Im, W.; Stansfeld, P. J.; Chavent, M.
10.1101/2022.06.29.498153 — biophysics — Posted on 2022-06-30
42 Structural insights into the assembly of gp130 family cytokine signaling complexes
Zhou, Y.; Stevis, P. E.; Cao, J.; Saotome, K.; Wu, J.; Zaretsky, A. G.; Haxhinasto, S.; Yancopoulos, G. D.; Murphy, A. J.; Sleeman, M. W.; Olson, W. C.; Franklin, M. C.
10.1101/2022.06.30.496838 — biochemistry — Posted on 2022-06-30
44 Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae
Foster-Nyarko, E.; Cottingham, H.; Wick, R. R.; Judd, L. M.; Lam, M. M. C.; Wyres, K. L.; Stanton, T. D.; Tsang, K. K.; David, S.; Aanensen, D. M.; Brisse, S.; Holt, K. E.
10.1101/2022.06.30.498322 — genomics — Posted on 2022-06-30
47 Evidence of selection in UCP1 gene region suggests local adaptation to irradiance rather than cold temperatures in savanna monkeys (Chlorocebus spp.)
Gagnon, C. M.; Svardal, H.; Jasinska, A. J.; Danzy Cramer, J.; Freimer, N. B.; Grobler, J. P.; Turner, T. R.; Schmitt, C. A.
10.1101/2022.06.28.496889 — genetics — Posted on 2022-06-30
48 Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions
Jacquet, S.; Culbertson, M.; Zang, C.; El Filali, A.; De La Myre Mory, C.; Pons, J.-B.; Filippi-Codaccioni, O.; Lauterbur, M. E.; Ngoubangoye, B.; Duhayer, J.; Verez, C.; Park, C.; Dahoui, C.; Carey, C. M.; Brennan, G. J.; Enard, D.; Cimarelli, A.; Rothenburg, S.; Elde, N. C.; Pontier, D.; Etienne, L.
10.1101/2022.06.28.497829 — evolutionary biology — Posted on 2022-06-30
51 Constitutive Activation and Oncogenicity Are Mediated by Loss of Helical Structure at the Cytosolic Boundary of the Thrombopoietin Receptor
Defour, J.-P.; Leroy, E.; Dass, S.; Balligand, T.; Levy, G.; Mouton, C.; Genet, L.; Pecquet, C.; Smith, S. O.; Constantinescu, S.
10.1101/2022.06.30.498238 — molecular biology — Posted on 2022-06-30
53 Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice
Rasmussen, T. S.; Mentzel, C. M. J.; Danielsen, M. R.; Jakobsen, R. R.; Andersen, L. S. F.; Castro-Mejia, J. L.; Hansen, L. H.; Hansen, A. K.; Nielsen, D. S.
10.1101/2022.06.30.498243 — microbiology — Posted on 2022-06-30
55 Avian and Human Influenza Viruses Exhibit Distinct Glycoconjugate Receptor Specificities in Human Lung Cells
Liang, C.-Y.; Huang, I.; Han, J.; Manivasagam, S.; Plung, J.; Sturtz, M.; Yu, Y.; Kandasamy, M.; Gourronc, F. A.; Klingelhutz, A. J.; Choudhury, B.; Rong, L.; Perez, J. T.; Neelamegham, S.; Manicassamy, B.
10.1101/2022.06.29.498208 — microbiology — Posted on 2022-06-30
58 Molecular mechanism of plasmid-borne resistance to sulfonamides
Venkatesan, M.; Fruci, M.; Verellen, L. A.; Skarina, T.; Mesa, N.; Stogios, P. J.; Savchenko, A.
10.1101/2022.06.30.498311 — microbiology — Posted on 2022-06-30
59 Trypanosoma cruzi isolates naturally adapted to congenital transmission display a unique strategy of transplacental passage
Faral-Tello, P.; Greif, G.; Romero, S.; Cabrera, A.; Oviedo, C.; Gonzalez, T.; Libisch, G.; Arevalo, A. P.; Varela, B.; Verdes, J. M.; Crispo, M.; Basmadjian, Y.; Robello, C.
10.1101/2022.06.30.498325 — microbiology — Posted on 2022-06-30
60 Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity
Laumaea, A.; Marchitto, L.; Beaudoin-Bussieres, G.; Ding, S.; Gasser, R.; Chatterjee, D.; Gendron-Lepage, G.; Medjahed, H.; Chen, H.-C.; Smith, A. B.; Ding, H.; Kappes, J. C.; Hahn, B. H.; Kirchhoff, F.; Richard, J.; Duerr, R.; Finzi, A.
10.1101/2022.06.30.498265 — microbiology — Posted on 2022-06-30
61 Identification and Mechanistic Basis of non-ACE2 Blocking Neutralizing Antibodies from COVID-19 Patients with Deep RNA Sequencing and Molecular Dynamics Simulations
Fredericks, A. M.; East, K. W.; Shi, Y.; Liu, J.; Maschietto, F.; Ayala, A.; Cioffi, W. G.; Cohen, M.; Fairbrother, W. G.; Lefort, C. T.; Nau, G. J.; Levy, M. M.; Wang, J.; Batista, V. S.; Lisi, G. P.; Monaghan, S. F.
10.1101/2022.06.29.498206 — immunology — Posted on 2022-06-30
62 Synaptic Location Is a Determinant of the Detrimental Effects of alpha-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Chen, L.; Nagaraja, C.; Daniels, S.; Fisk, Z. A.; Dvorak, R.; Meyerdirk, L.; Steiner, J. A.; Galvis, M. L. E.; Henderson, M.; Rousseaux, M.; Brundin, P.; Chu, H.-y.
10.1101/2022.02.20.481207 — neuroscience — Posted on 2022-06-30
63 The Interictal Suppression Hypothesis in Focal Epilepsy: Electrographic and Structural Evaluation
Johnson, G. W.; Doss, D. J.; Morgan, V. L.; Shless, J. S.; Paulo, D. L.; Kang, H.; Bick, S. K.; Roberson, S. W.; Wallace, M. T.; Englot, D. J.
10.1101/2022.06.27.497765 — neuroscience — Posted on 2022-06-30
67 Cell surface receptor kinase FERONIA linked to nutrient sensor TORC1 signaling controls root hair growth at low temperature in Arabidopsis thaliana
Pacheco, J. M.; Song, L.; Kubenova, L.; Ovecka, M.; Gabarain, V. B.; Peralta, J. M.; Lehuede, T. U.; Ibeas, M. A.; Zhu, S.; Shen, Y.; Schepetilnikov, M.; Ryabova, L.; Alvarez, J.; Gutierrez, R. A.; Grossmann, G.; Samaj, J.; Yu, F.; Estevez, J. M.
10.1101/2022.01.10.475584 — plant biology — Posted on 2022-06-30
69 Genome sequence assembly evaluation using long-range sequencing data
Guan, D.; McCarthy, S.; Wood, J.; Ning, Z.; Sims, Y.; Chow, W.; Howe, K.; Wang, G.; Wang, Y.; Durbin, R.
10.1101/2022.05.10.491304 — bioinformatics — Posted on 2022-06-30
70 Discovery of a conserved rule behind the assembly of β-barrel membrane proteins.
Germany, E. M.; Thewasano, N.; Imai, K.; Maruno, Y.; Bamert, R. S.; Dunstan, R. A.; Ding, Y.; Nakajima, Y.; Lai, X.; Webb, C. T.; Stubenrauch, C. J.; Hidaka, K.; Tan, K. S.; Shen, H.-H.; Lithgow, T.; Shiota, T.
10.1101/2021.10.29.466387 — biochemistry — Posted on 2022-06-30
75 Circadian regulation of dentate gyrus excitability mediated by G-protein signaling
Gonzalez, J. C.; Lee, H.; Vincent, A. M.; Goode, L. K.; King, G. D.; Gamble, K. L.; Wadiche, J. I.; Overstreet-Wadiche, L.
10.1101/2022.06.28.497975 — neuroscience — Posted on 2022-06-30
78 Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism
Lim, R. G.; Al-Dalahmah, O.; Wu, J. M.; Gold, M. P.; Reidling, J. C.; Tang, G.; Adam, M.; Dansu, D. K.; Park, H.-J.; Casaccia, P.; Miramontes, R.; Reyes-Ortiz, A. M.; Lau, A.; Khan, F.; Paryani, F.; Tang, A.; Ofori, K. N. A.; Miyoshi, E.; Michael, N.; Geller, N.; Flowers, X. E.; Vonsattel, J. P.; Davidson, S.; Menon, V.; Swarup, V.; Fraenkel, E.; Goldman, J. E.; Thompson, L. M.
10.1101/2022.06.27.497613 — neuroscience — Posted on 2022-06-30
81 Ultra-slow fMRI fluctuations in the fourth ventricle as a marker of drowsiness
Gonzalez-Castillo, J.; Fernandez, I.; Handwerker, D. A.; Bandettini, P. A.
10.1101/2021.07.08.451677 — neuroscience — Posted on 2022-06-30
82 A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
Abdel-Haq, R.; Schlachetzki, J. C. M.; Boktor, J. C.; Cantu-Jungles, T. M.; Thron, T.; Zhang, M.; Bostick, J. W.; Khazaei, T.; Chilakala, S.; Morais, L. H.; Humphrey, G.; Keshavarzian, A.; Katz, J. E.; Thomson, M.; Knight, R.; Gradinaru, V.; Hamaker, B. R.; Glass, C. K.; Mazmanian, S. K.
10.1101/2022.06.27.497828 — physiology — Posted on 2022-06-30
83 Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
Schmitz, U.; Gilmore, S. A.; Tam, D.; Cheung, T. L.; Snyder, C.; Farand, J.; Dick, R.; Matles, M.; Feng, J. Y.; Ramirez, R.; Li, L.; Yu, H.; Xu, Y.; Barnes, D.; Czerwieniec, G.; Brendza, K. M.; Appleby, T. C.; Birkus, G.; Willkom, M.; Kobayashi, T.; Paoli, E.; Labelle, M.; Boesen, T.; Tay, C. H.; Delaney, W. E.; Notte, G. T.; Feierbach, B.
10.1101/2022.06.27.497732 — pharmacology and toxicology — Posted on 2022-06-30
90 Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c
Oates, T. C.; Moura, P. L.; Cross, S. J.; Roberts, K.; Baum, H. E.; Haydn-Smith, K.; Wilson, M. C.; Heesom, K. J.; Severn, C. E.; Toye, A. M.
10.1101/2022.06.13.495868 — immunology — Posted on 2022-06-30
95 Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections
Labbe, F.; He, Q.; Zhan, Q.; Tiedje, K. E.; Argyropoulos, D. C.; Tan, M. H.; Ghansah, A.; Day, K. P.; Pascual, M.
10.1101/2022.06.27.497801 — evolutionary biology — Posted on 2022-06-30
101 Neural correlates of changing food choices while bypassing values
Zahedi, A.; Artigas, S. O.; Swaboda, N.; Wiers, C. E.; Goergen, K.; Park, S. Q.
10.1101/2022.06.27.497771 — neuroscience — Posted on 2022-06-30
103 Hexokinase 1b is a novel target for non-small-cell lung cancer
Yozgat, Y.; Karakoc, E.; Sahin, O.; Cimen, S.; Rabeh, W. M.; Aydin, M. S.; Mardinoglu, A.; Gursel, I.; Cakir, A.; Sensoy, O.; Ozdemir, E. M.; Bayrak, Y.; Gunluoglu, M. Z.; Saatci, O.; Jabbar, J.; Ferreira, J. C.; Aslan, M. D.; Yildirim, M.; Mansoor, S.; Kerman, B. E.; Aladag, Z.; Kim, W.; Arif, M.; Vatandaslar, E.; Tok, O. E.; Dogru, Z.; Demir, A. G. O.; Yildirim, T. C.; Yozgat, I.; Senturk, S.; Ozturk, G.; Cevher, M. A.
10.1101/2022.06.27.497447 — cancer biology — Posted on 2022-06-30
109 Genomic evidence for ancient migrations routes along South America's Atlantic coast
dos Santos, A. L. C.; Owings, A.; Sullasi, H. S. L.; Gokcumen, O.; DeGiorgio, M.; Lindo, J.
10.1101/2022.06.27.497820 — genomics — Posted on 2022-06-30
113 Vitamin D and the ability to produce 1,25(OH)2D are critical for protection from viral infection of the lungs.
Arora, J.; Patel, D. R.; Nicol, M. J.; Field, C. J.; Restori, K. H.; Wang, J.; Froelich, N. E.; Katkere, B.; Terwilliger, J. A.; Weaver, V.; Luley, E.; Kelly, K.; Kirimanjeswara, G. S.; Sutton, T. C.; Cantorna, M. T.-A.
10.1101/2022.06.29.498158 — immunology — Posted on 2022-06-30
115 Trapping virus-loaded aerosols using granular protein nanofibrils and iron oxyhydroxides nanoparticles
Armanious, A.; Wang, H.; Alpert, P.; Medaglia, C.; Peydayesh, M.; Zwygart, A. C.-A.; Gübeli, C.; Handschin, S.; Bolisetty, S.; Ammann, M.; Tapparel, C.; Stellacci, F.; Mezzenga, R.
10.1101/2022.06.29.498082 — microbiology — Posted on 2022-06-30
117 APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
Zhao, J.; Ikezu, T. C.; Lu, W.; Macyczko, J. R.; Li, Y.; Lewis-Tuffin, L. J.; Martens, Y. A.; Ren, Y.; Zhu, Y.; Asmann, Y.; Taner, N.; Kanekiyo, T.; Bu, G.
10.1101/2022.06.30.498241 — cell biology — Posted on 2022-06-30
119 Using kinetic modelling to infer adaptations in Saccharomyces cerevisiae carbohydrate storage metabolism to feast famine regimes
Lao-Martil, D.; Verhagen, K. J. A.; Valdeira Caetano, A. H.; Pardijs, I. H.; van Riel, N. A. W.; Wahl, S. A.
10.1101/2022.06.28.497175 — systems biology — Posted on 2022-06-30
124 Unraveling the mystery behind the short-day-specific flowering of tobacco cultivar Maryland Mammoth
Zimmermann, M. M.; Grundmann, L.; Kaenel, A.; Schwarze, A.; Wiedmann, D. R.; Muth, J.; Twymann, R. M.; Pruefer, D.; Noll, G. A.
10.1101/2022.06.27.497884 — plant biology — Posted on 2022-06-30
125 Chloroplast activity provides in vitro regeneration capability in contrasting cultivars
Sirohi, P.; Chaudhary, C.; Baliyan, S.; Vishnoi, R.; Mishra, S. K.; Chaudhary, R.; Waghmode, B.; Poonia, A. K.; Germain, H.; Sircar, D.; Chauhan, H.
10.1101/2022.06.30.498295 — plant biology — Posted on 2022-06-30
127 Rieske FeS overexpression in tobacco provides increased abundance and activity of Cytochrome b6f
Heyno, E. A.; Ermakova, M.; Lopez-Calcagno, P. E.; Woodford, R.; Brown, K. L.; Matthews, J. S.; Osmond, C. B.; Raines, C. A.; von Caemmerer, S.
10.1101/2022.06.28.497970 — plant biology — Posted on 2022-06-30
129 Function and phylogeny support the independent evolution of acid-sensing ion channels in the Placozoa
Elkhatib, W.; Yanez-Guerra, L. A.; Mayorova, T. D.; Currie, M. A.; Perera, M.; Singh, A.; Gauberg, J.; Senatore, A.
10.1101/2022.06.28.497943 — evolutionary biology — Posted on 2022-06-30
131 Optimal transport analysis of single-cell transcriptomics directs hypotheses prioritization and validation
Singh, R.; Li, J. S. S.; Tattikota, S. G.; Liu, Y.; Xu, J.; Hu, Y.; Perrimon, N.; Berger, B.
10.1101/2022.06.27.497786 — bioinformatics — Posted on 2022-06-30
132 Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones
Lima, N. S.; Musayev, M.; Johnston, T. S.; Wagner, D. A.; Henry, A. R.; Wang, L.; Yang, E. S.; Zhang, Y.; Birungi, K.; Black, W. P.; O'Dell, S.; Schmidt, S. D.; Moon, D.; Lorang, C. G.; Zhao, B.; Chen, M.; Boswell, K. L.; Roberts-Torres, J.; Davis, R. L.; Peyton, L.; Narpala, S. R.; O'Connell, S.; Wang, J.; Schrager, A.; Talana, C. A.; Leung, K.; Shi, W.; Khashab, R.; Biber, A.; Zilberman, T.; Rhein, J.; Vetter, S.; Ahmed, A.; Novik, L.; Widge, A.; Gordon, I.; Guech, M.; Teng, I.-T.; Phung, E.; Ruckwardt, T. J.; Pegu, A.; Misasi, J.; Doria-Rose, N. A.; Gaudinski, M.; Koup, R. A.; Kwong, P. D.;
10.1101/2022.03.28.486152 — immunology — Posted on 2022-06-30
134 PipeIT2: A tumor-only somatic variant calling workflow for Molecular Diagnostic Ion Torrent sequencing data
Schnidrig, D.; Garofoli, A.; Benjak, A.; Ratsch, G.; Rubin, M.; SOCIBP consortium, ; Piscuoglio, S.; Ng, C. K.
10.1101/2022.06.28.497937 — bioinformatics — Posted on 2022-06-30
136 WATLAS: high throughput and real-time tracking of many small birds in the Dutch Wadden Sea
Bijleveld, A. I.; van Maarseveen, F.; Denissen, B.; Dekinga, A.; Penning, E.; Ersoy, S.; Gupte, P.; de Monte, L.; ten Horn, J.; Bom, R.; Toledo, S.; Nathan, R.; Beardsworth, C.
10.1101/2021.11.08.467683 — ecology — Posted on 2022-06-30
137 The LncRNA Carmn is a Critical Regulator for Gastrointestinal Smooth Muscle Contractile Function and Motility
He, X.; Dong, K.; Shen, J.; Hu, G.; Mintz, J. D.; Atawia, R. T.; Zhao, J.; Chen, X.; Caldwell, R. W.; Xiang, M.; Stepp, D. W.; Fulton, D. J.; Zhou, J.
10.1101/2022.06.28.498024 — cell biology — Posted on 2022-06-30
139 Specific conformational dynamics of the ATPase head domains and DNA exit gate mediate the Cohesin ATPase cycle
Vitoria Gomes, M.; landwerlin, P.; Diebold-Durand, M.-L.; Shaik, T. B.; Troesch, E.; Weber, C.; Durand, A.; Brillet, K.; Dulac, L.; Antony, P.; Watrin, E.; Ennifar, E.; Golzio, C.; Romier, C.
10.1101/2022.06.24.497451 — biochemistry — Posted on 2022-06-30
142 Theta oscillations in the human hippocampus normalize the information content of episodic memory
Pata, D.; Zucca, R.; Amil, A. F.; Principe, A.; Perez-Enriquez, C.; Rocamora, R.; Kwok, S. C.; Verschure, P. F.
10.1101/2022.06.27.497705 — neuroscience — Posted on 2022-06-30
143 Frequent spontaneous structural rearrangements promote transgenerational genome diversification in Brassica napus
Orantes-Bonilla, M.; Makhoul, M.; Lee, H.; Singh Chawla, H.; Vollrath, P.; Langstroff, A.; Sedlazeck, F. J.; Zou, J.; Snowdon, R. J.
10.1101/2022.06.27.497715 — genomics — Posted on 2022-06-30
144 Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Lu, Y.; Cho, T.; Mukherjee, S.; Malik, A. A.; Gonzlez-Foutel, N.; Oh, R.; Langille, E.; Al-Zahrani, K.; Lin, Z.; Rotter, V.; Ashton-Prolla, P.; Chemes, L. B.; Moffat, J.; Gingras, A.-C.; Oren, M.; Durocher, D.; Schramek, D.
10.1101/2022.03.13.483372 — cancer biology — Posted on 2022-06-30
155 Lupus disease flares are concordant with immune responses to blooms of lipoglycan-expressing Ruminococcus blautia gnavus strains arising from unstable gut microbiota communities
Azzouz, D. F.; Chen, Z.; Izmirly, P.; Chen, L. A.; Li, Z.; Pironti, A.; Putzel, G. G.; Zhang, C.; Heguy, A.; Masson, M.; Schwudke, D.; Fenyo, D.; Gisch, N.; Buyon, J. H.; Alekseyenko, A. V.; Silverman, G. J.
10.1101/2022.06.28.498027 — immunology — Posted on 2022-06-29
156 A tetracycline antibiotic minocycline prevents early aging phenotypes in mice heterozygous for RP58
Tanaka, T.; Hirai, S.; Manabe, H.; Endo, K.; Nishito, Y.; Shimbo, H.; Yoshitane, H.; okado, h.
10.1101/2021.09.18.460879 — neuroscience — Posted on 2022-06-29
158 AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana
Lemus, T.; Mason, G. A.; Bubb, K. L.; Alexandre, C. M.; Queitsch, C.; Cuperus, J. T.
10.1101/2022.06.27.497824 — plant biology — Posted on 2022-06-29
159 Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts
Sathe, A.; Mason, K.; Grimes, S. M.; Zhou, Z.; Lau, B. T.; Bai, X.; Su, A.; Tan, X.; Lee, H.; Suarez, C.; Nguyen, Q.; Poultsides, G.; Zhang, N.; Ji, H. P.
10.1101/2020.09.01.273672 — cancer biology — Posted on 2022-06-29
160 Predicting the locations of cryptic pockets from single protein structures using the PocketMiner graph neural network
Meller, A.; Ward, M.; Borowsky, J.; Lotthammer, J. M.; Kshirsagar, M.; Oviedo, F.; Lavista Ferres, J.; Bowman, G. R.
10.1101/2022.06.28.497399 — biophysics — Posted on 2022-06-29
161 A flexible electronic strain sensor for the real-time monitoring of tumor regression
Abramson, A.; Chan, C.; Khan, Y.; Mermin-Bunnell, A.; Matsuhisa, N.; Fong, R.; Shad, R.; Hiesinger, W.; Mallick, P.; Gambhir, S. S.; Bao, Z.
10.1101/2021.09.16.460551 — bioengineering — Posted on 2022-06-29
167 mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data
Li, A.; Liu, S.; Bakshi, A.; Jiang, L.; Chen, W.; Zheng, Z.; Sullivan, P. F.; Visscher, P. M.; Wray, N. R.; Yang, J.; Zeng, J.
10.1101/2022.06.27.497850 — genetics — Posted on 2022-06-29
169 Taxonomic assessment of two wild house mouse subspecies using whole genome sequencing
Lawal, R. A.; Mathis, V. L.; Barter, M. E.; Charette, J. R.; Garretson, A.; Dumont, B. L.
10.1101/2022.06.28.497812 — evolutionary biology — Posted on 2022-06-29
171 Past, present, and future of the Living Planet Index
Ledger, S. E. H.; McRae, L.; Böhm, M.; Almond, R.; Grooten, M.; Clements, C.; Currie, J.; Galewski, T.; Jenkins, M.; Painter, B.; Young, L.; Loh, J.; Deinet, S.; Marconi, V.; Scott-Gatty, K.; Hoffmann, M.; Freeman, R.
10.1101/2022.06.20.496803 — ecology — Posted on 2022-06-29
172 Activity-driven extracellular volume expansion drives vertebrate axis elongation
Michaut, A.; Mongera, A.; Gupta, A.; Serra, M.; Rigoni, P.; Lee, J. G.; Duarte, F.; Hall, A. R.; Mahadevan, L.; Guevorkian, K.; Pourquie, O.
10.1101/2022.06.27.497799 — developmental biology — Posted on 2022-06-29
173 Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination
Kiss, L.; Rhinesmith, T.; Dickson, C. F.; Weidenhausen, J.; Smyly, S.; Luptak, J.; Yang, J.-C.; Maslen, S. L.; Sinning, I.; Neuhaus, D.; Clift, D.; James, L. C.
10.1101/2022.06.29.498105 — molecular biology — Posted on 2022-06-29
174 The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer
Constantin, T. A.; Varela-Carver, A.; Greenland, K. K.; Serrano de Almeida, G.; Penfold, L.; Ang, S.; Ormrod, A.; Ainscow, E. K.; Bahl, A. K.; Carling, D.; Fuchter, M. J.; Ali, S.; Bevan, C. L.
10.1101/2022.06.29.497030 — molecular biology — Posted on 2022-06-29
176 The nuclear GAPDH-HMGB cascade in cortical microglia regulates cognitive flexibility
Ramos, A.; Ishizuka, K.; Namkung, H.; Hayes, L. N.; Saito, A.; Sengupta, A.; Srivastava, R.; Calva, C.; Hayashida, A.; Elkins, N.; Palen, T.; Carloni, E.; Tsujimura, T.; Gallego, J. A.; Robinson, D. G.; Malhotra, A. K.; Ikemoto, S.; Rais, R.; Slusher, B. S.; Niwa, M.; Saitoh, T.; Takimoto, E.; Sawa, A.
10.1101/2022.06.21.497065 — molecular biology — Posted on 2022-06-29
178 Single-nuclei Transcriptome of Human Adipose Tissue Reveals Metabolically Distinct Depot-Specific Adipose Progenitor Subpopulations
Barboza, C. S.; Flesher, C.; Geletka, L.; Delproposto, J.; Eichler, T.; Akinleye, O.; Ky, A.; Ehlers, A.; O'Rourke, R.; Lumeng, C. N.
10.1101/2022.06.29.496888 — molecular biology — Posted on 2022-06-29
179 The immunodominant protein P116 is a passive transporter of cholesterol and other essential lipids
Sprankel, L.; Vizarraga, D.; Martin, J.; Manger, S.; Meier-Credo, J.; Marcos, M.; Julve, J.; Rotllan, N.; Scheffer, M. P.; Escola-Gil, J. C.; Langer, J.; Pinyol, J.; Fita, I.; Frangakis, A. S.
10.1101/2022.06.28.498018 — microbiology — Posted on 2022-06-29
181 PDGFRα+ fibroblasts are a major site of cytomegalovirus replication in vivo and genome maintenance during latency
Sitnik, K. M.; Krstanovic, F.; Goedecke, N.; Rand, U.; Kubsch, T.; Maas, H.; Kim, Y.; Brizic, I.; Cicin-Sain, L.
10.1101/2022.06.29.498076 — microbiology — Posted on 2022-06-29
182 Reactive oxygen species-based sensing by a single chemoreceptor controls bacterial chemotaxis to copper
Louis, G.; Cherry, P.; Michaux, C.; Rahuel-Clermont, S.; Dieu, M.; Tilquin, F.; Maertens, L.; Van Houdt, R.; Renard, P.; Perpete, E.; Matroule, J.-Y.
10.1101/2022.06.29.497744 — microbiology — Posted on 2022-06-29
185 Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis
Saqib, M.; McDonough, E.; Das, S.; Cheng, Z.; Sankar, P.; Li, F.; Yang, Q.; Xu, Y.; Wang, W.; Chen, X.; Ojha, A. K.; Ginty, F.; Cai, Y.; Mishra, B. B.
10.1101/2022.06.28.498035 — immunology — Posted on 2022-06-29
186 Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
Karmakar, S.; Volpedo, G.; Zhang, W.-W.; Lypaczewski, P.; Ismail, N.; Oliveira, L. F.; Oristian, J.; Meneses, C.; Gannavaram, S.; Kamhawi, S.; Hamano, S.; Valenzuela, J. G.; DEY, R.; Satoskar, A. R.; Matlashewski, G.; Nakhasi, H.
10.1101/2022.06.27.497754 — immunology — Posted on 2022-06-29
188 ZO1 scaffold isoforms differentially contribute to electrical synapse formation
Michel, J. C.; Grivette, M. M. B.; Harshfield, A. T.; Huynh, L.; Loomis, B.; McKinnis, K.; Miller, B. T.; Huang, T. W.; Lauf, S.; Michel, M. E.; Marsh, A. J.; Kaye, L. E.; Lukowicz-Bedford, R. M.; Farnsworth, D. R.; Martin, E. A.; Miller, A. C.
10.1101/2022.06.27.497867 — neuroscience — Posted on 2022-06-29
190 Increasing Muscle Hypertrophy with a Natural Product Designed to Inhibit SIRT1
Pathak, S.; Wallace, M.; Athalye, S.; Schenk, S.; Langer, H. T.; Baar, K.
10.1101/2022.06.27.497838 — physiology — Posted on 2022-06-29
191 The differential metabolic signature of breast cancer cellular response to olaparib treatment
Berardi, D.; Hunter, Y.; van den Driest, L.; Farrell, G.; Rattray, N. J.; Rattray, Z.
10.1101/2022.06.14.495928 — cancer biology — Posted on 2022-06-29
192 STRAINS: A Big Data Method for Classifying Cellular Response to Stimuli at the Tissue Scale
Zheng, J.; Jackson, T. W.; Fortier, L. A.; Bonassar, L. J.; Delco, M.; Cohen, I.
10.1101/2022.06.12.495830 — biophysics — Posted on 2022-06-29
194 Genome sequence assembly evaluation using long-range sequencing data
Guan, D.; McCarthy, S.; Wood, J.; Ning, Z.; Sims, Y.; Chow, W.; Howe, K.; Wang, G.; Wang, Y.; Durbin, R.
10.1101/2022.05.10.491304 — bioinformatics — Posted on 2022-06-29
197 Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories
Bentley, B. P.; Carrasco-Valenzuela, T.; Ramos, E. K. S.; Pawar, H.; Arantes, L. S.; Alexander, A.; Banerjee, S. M.; Masterson, P.; Kuhlwilm, M.; Pippel, M.; Mountcastle, J.; Haase, B.; Silva, M. U.; Formenti, G.; Howe, K.; Chow, W.; Tracey, A.; Sims, Y.; Pelan, S.; Wood, J.; Yetsko, K.; Perrault, J. R.; Stewart, K.; Benson, S.; Levy, Y.; Todd, E. V.; Shaffer, H. B.; Scott, P.; Henen, B. T.; Murphy, R. W.; Mohr, D. W.; Scott, A. F.; Duffy, D. J.; Gemmell, N.; Suh, A.; Winkler, S.; Thibaud-Nissen, F.; Nery, M. F.; Marques-Bonet, T.; Antunes, A.; Tikochinski, Y.; Dutton, P. H.; Fedrigo, O.; Myer
10.1101/2022.01.10.475373 — genomics — Posted on 2022-06-29
198 Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease
Ameen, M.; Sundaram, L.; Banerjee, A.; Shen, M.; Kundu, S.; Nair, S.; Shcherbina, A.; Gu, M.; Wilson, K. D.; Varadarajan, A.; Vadgama, N.; Balsubramani, A.; Wu, J. C.; Engreitz, J.; Farh, K.; Karakikes, I.; Wang, K. C.; Quertermous, T.; Greenleaf, W.; Kundaje, A.
10.1101/2022.06.29.498132 — genomics — Posted on 2022-06-29
200 Bitter taste perception in BaYaka hunter-gatherers
Keestra, S. M.; Mianbangana, E. S.; Chaudhary, N.; Derkx, I.; Sikka, G.; Salali, G. D.
10.1101/2021.11.25.469973 — ecology — Posted on 2022-06-29
201 Attachment of the RNA degradosome to the inner cytoplasmic membrane of Escherichia coli prevents wasteful degradation of rRNA intermediates in ribosome assembly.
Hadjeras, L.; Bouvier, M.; Canal, I.; Poljak, L.; Morin-Ogier, Q.; Froment, C.; Burlet-Schlitz, O.; Hamouche, L.; Girbal, L.; Cocaign-Bousquet, M.; Carpousis, A. J.
10.1101/2022.06.14.496040 — molecular biology — Posted on 2022-06-29
207 An individualized fMRI protocol to assess semantic congruency effects on episodic memory in an aging multilingual population
Perquin, M.; Viswanathan, S.; Vaillant, M.; Risius, O.; Huiart, L.; Schmit, J.-C.; Diederich, N. J.; Fink, G. R.; Kukolja, J.
10.1101/2021.09.07.459272 — neuroscience — Posted on 2022-06-29
211 Frequent spontaneous structural rearrangements promote transgenerational genome diversification in Brassica napus
Orantes-Bonilla, M.; Makhoul, M.; Lee, H.; Singh Chawla, H.; Vollrath, P.; Langstroff, A.; Sedlazeck, F. J.; Zou, J.; Snowdon, R. J.
10.1101/2022.06.27.497715 — genomics — Posted on 2022-06-29
213 Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe
Rapan, L.; Froudist-Walsh, S.; Niu, M.; Xu, T.; Zhao, L.; Funck, T.; Wang, X. J.; Amunts, K.; Palomero-Gallagher, N.
10.1101/2022.06.27.497757 — neuroscience — Posted on 2022-06-29
214 A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer
Chiang, C.; Zhang, M.; Huang, J.; Zeng, J.; Chen, C.; Pan, D.; Yang, H.; Yang, M.; Han, Q.; Zou, W.; Xiao, T.; Zou, Y.; Yin, F.; Li, Z.; Zhu, L.; Zheng, D.
10.1101/2022.06.27.497627 — pharmacology and toxicology — Posted on 2022-06-29
215 YAP and collagen remodelling support cell proliferation and tumour aggressiveness in uterine leiomyosarcoma
Gonzalez-Molina, J.; Hahn, P.; Falcao, R. M.; Gultekin, O.; Kokaraki, G.; Zanfagnin, V.; Petta, T. B.; Lehti, K.; Carlson, J. W.
10.1101/2022.06.27.497746 — cancer biology — Posted on 2022-06-29
216 Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r
Boudry, A.; Darmon, S.; Duployez, N.; Figeac, M.; Geffroy, S.; Bucci, M.; Celli-Lebras, K.; Duchmann, M.; Joudinaud, R.; Fenwarth, L.; Nibourel, O.; Goursaud, L.; Itzykson, R.; Dombret, H.; Hunault, M.; Preudhomme, C.; Salson, M.
10.1101/2022.06.27.496265 — bioinformatics — Posted on 2022-06-29
218 Investigating the mechanistic role of painful self-experience in emotional contagion: an effect of auto-conditioning?
Packheiser, J.; Soyman, E.; Paradiso, E.; Ramaaker, E.; Sahin, N.; Muralidharan, S.; Wohr, M.; Gazzola, V.; Keysers, C.
10.1101/2022.06.27.497737 — animal behavior and cognition — Posted on 2022-06-29
219 PaliDIS: A tool for fast discovery of novel insertion sequences
Carr, V. R.; Pissis, S. P.; Mullany, P.; Shoaie, S.; Gomez-Cabrero, D.; Moyes, D. L.
10.1101/2022.06.27.497710 — genomics — Posted on 2022-06-29
221 Viral diversity and zoonotic risk in endangered species
Nikc, K.; Albery, G. F.; Becker, D.; Eskew, E. A.; Fagre, A. C.; Ryan, S. J.; Carlson, C. J.
10.1101/2022.06.27.497730 — ecology — Posted on 2022-06-29
222 Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing
Richardson, E.; Binter, S.; Kosmac, M.; Ghraichy, M.; von Niederhäusern, V.; Kovaltsuk, A.; Galson, J. D.; Trück, J.; Kelly, D. F.; Deane, C. M.; Kellam, P.; Watson, S.
10.1101/2022.06.27.497709 — immunology — Posted on 2022-06-29
225 Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
Neffe, J.; Gilmore, S. A.; Tam, D.; Cheung, T. L.; Snyder, C.; Farand, J.; Dick, R.; Matles, M.; Feng, J. Y.; Ramirez, R.; Li, L.; Yu, H.; Xu, Y.; Barnes, D.; Czerwieniec, G.; Brendza, K. M.; Appleby, T. C.; Birkus, G.; Willkom, M.; Kobayashi, T.; Paoli, E.; Labelle, M.; Boesen, T.; Tay, C. H.; Delaney, W. E.; Notte, G. T.; Feierbach, B.
10.1101/2022.06.27.497732 — pharmacology and toxicology — Posted on 2022-06-29
226 Safety and uptake of fully oxidized β-carotene
Burton, G. W.; Mogg, T. J.; Stupak, J.; Stark, F. C.; Twine, S. M.; Li, J.
10.1101/2022.06.27.497750 — pharmacology and toxicology — Posted on 2022-06-29
230 On the similarities of representations in artificial and brain neural networks for speech recognition
Wingfield, C.; Zhang, C.; Devereux, B.; Fonteneau, E.; Thwaites, A.; Liu, X.; Woodland, P.; Marslen-Wilson, W.; Su, L.
10.1101/2022.06.27.497678 — neuroscience — Posted on 2022-06-29
234 Spatio-temporal dynamics of nuclear CREB1: what does it mean?
Farias Altamirano, L. E.; Vasquez, E.; Freites, C. L.; Ibanez, J. E.; Guido, M. E.; Munoz, E. M.
10.1101/2022.06.26.497665 — neuroscience — Posted on 2022-06-29
235 Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania
Cuypers, B.; Meysman, P.; Erb, I.; Bittremieux, W.; Valkenborg, D.; Baggerman, G.; Mertens, I.; Sundar, S.; Khanal, B.; Notredame, C.; Dujardin, J.-C.; Domagalska, M. A.; Laukens, K.
10.1101/2021.09.14.460245 — systems biology — Posted on 2022-06-29
237 Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization
Zhou, S.; Wu, Y.; zhao, Y.; Zhang, Z.; Jiang, L.; Liu, L.; Zhang, Y.; Tang, J.; Yuan, Y.-J.
10.1101/2021.07.19.453002 — synthetic biology — Posted on 2022-06-29
240 Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections
Fries, M.; Brown, T.; Jolicoeur, C.; Abram, P.; Boudreau-Pinsonneault, C.; Javed, A.; Cayouette, M.
10.1101/2022.06.28.497982 — developmental biology — Posted on 2022-06-29
243 Epo-IGF1R crosstalk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm
Huang, L.; Hsieh, H.-h.; Yao, H.; Ma, Y.; Zhang, Y.; Xiao, X.; Stephens, H.; Chung, S. S.; Xu, L.; Xu, J.; Rampal, R. K.
10.1101/2022.06.27.497649 — developmental biology — Posted on 2022-06-29
249 Linking Parasitism to Network Centrality and the Impact of Sampling Bias in its Interpretation
XU, Z.; MacIntosh, A. J. J.; Castellano-Navarro, A.; Macanas-Martuinez, E.; Suzumura, T.; Duboscq, J.
10.1101/2021.06.07.447302 — animal behavior and cognition — Posted on 2022-06-29
251 Functional succession of actively growing soil microorganisms during rewetting is shaped by precipitation history
Sieradzki, E. T.; Greenlon, A.; Nicolas, A. M.; Firestone, M. K.; Pett-Ridge, J.; Blazewicz, S. J.; Banfield, J.
10.1101/2022.06.28.498032 — microbiology — Posted on 2022-06-29
255 Intrinsic Neural Timescales in Autism Spectrum Disorder and Schizophrenia. A Replication and Direct Comparison Study
Uscatescu, L. C.; Kronbichler, M.; Yuerekli, S. S.; Kronbichler, L.; Calhoun, V.; Corbera, S.; Bell, M.; Pelphrey, K.; Pearlson, G.; Assaf, M.
10.1101/2022.06.26.497652 — neuroscience — Posted on 2022-06-29
265 Predicting the locations of cryptic pockets from single protein structures using the PocketMiner graph neural network
Meller, A.; Ward, M.; Borowsky, J.; Lotthammer, J. M.; Kshirsagar, M.; Oveido, F.; Lavista Ferres, J.; Bowman, G. R.
10.1101/2022.06.28.497399 — biophysics — Posted on 2022-06-29
267 The role of wingbeat frequency and amplitude in flight power
Krishnan, K.; Garde, B.; Bennison, A.; Cole, N. C.; Cole, E.-L.; Darby, J.; Elliott, K. H.; Fell, A.; Gómez-Laich, A.; Grissac, S. d.; Jessopp, M.; Lempidakis, E.; Mizutani, Y.; Prudor, A.; Quetting, M.; Quintana, F.; Robotka, H.; Roulin, A.; Ryan, P. G.; Schalcher, K.; Schoombie, S.; Tatayah, V.; Tremblay, F.; Weimerskirch, H.; Whelan, S.; Wikelski, M.; Yoda, K.; Hedenström, A.; Shepard, E. L. C.
10.1101/2022.06.28.497935 — biophysics — Posted on 2022-06-29
268 Geometric effects in gas vesicle buckling under ultrasound
Salahshoor, H.; Yao, Y.; Dutka, P.; Nystrom, N. N.; Jin, Z.; Min, E.; Malounda, D.; Jensen, G. J.; Shapiro, M. G.
10.1101/2022.06.27.497663 — biophysics — Posted on 2022-06-29
273 ADGRG6 promotes adipogenesis and is involved in sex-specific fat distribution
Nguyen, H. P.; Ushiki, A.; Sheng, R.; Biellak, C.; An, K.; Choquet, H.; Hoffmann, T.; Gray, R. S.; Ahituv, N.
10.1101/2022.06.24.497411 — genomics — Posted on 2022-06-29
274 Phase separation of Myc differentially regulates gene transcription
Yang, J.; Chung, C.-I.; Koach, J.; Liu, H.; Zhao, Q.; Yang, X.; Shen, Y.; Weiss, W. A.; Shu, X.
10.1101/2022.06.28.498043 — cell biology — Posted on 2022-06-29
275 Impact of maternal iron deficiency anaemia on fetal iron status and placental iron transporters in human pregnancy
Santhakumar, S.; Athiyarath, R.; Cherian, A. G.; Abraham, V. J.; George, B.; Lipinski, P.; Edison, E. S.
10.1101/2022.06.29.498050 — molecular biology — Posted on 2022-06-29
279 A non-destructive approach for measuring rice panicle-level photosynthetic responses using 3D-image reconstruction
Singh, J.; Dhatt, B. K.; Paul, P.; Gao, T.; Awada, T.; Staswick, P.; Hupp, J.; Yu, H.; Walia, H.
10.1101/2022.06.25.497601 — physiology — Posted on 2022-06-29
281 The Injured Sciatic Nerve Atlas (iSNAT), Insights into the Cellular and Molecular Basis of Neural Tissue Degeneration and Regeneration
Zhao, X.-F.; Huffman, L. D.; Hafner, H.; Athaiya, M.; Finneran, M.; Kalinski, A. L.; Kohen, R.; Flynn, C.; Passino, R.; Johnson, C. N.; Kohrman, D.; Kawaguchi, R.; Yang, L.; Twiss, J. L.; Geschwind, D. H.; Corfas, G.; Giger, R. J.
10.1101/2022.06.26.497651 — neuroscience — Posted on 2022-06-29
286 Accurate background reduction in adaptive optical 3D-STED nanoscopy by dynamic phase switching
Tu, S.; Liu, X.; Yuan, D.; Tao, W.; Han, Y.; Shi, Y.; Li, Y.; Kuang, C.; Liu, X.; Yao, Y.; Xu, Y.; Hao, X.
10.1101/2022.06.25.497623 — biophysics — Posted on 2022-06-29
287 Accurate and efficient protein sequence designthrough learning concise local environment of residues
Huang, B.; Fan, T.; Wang, K.; Zhang, H.; Yu, C.; Nie, S.; Qi, Y.; Zheng, W.-M.; Han, J.; Fan, Z.; Sun, S.; Ye, S.; Yang, H.; Bu, D.
10.1101/2022.06.25.497605 — bioinformatics — Posted on 2022-06-29
290 Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks
Appadurai, V.; Bybjerg-Grauholm, J.; Krebs, M.; Rosengren, A.; Buil, A.; Ingason, A.; Mors, O.; Borglum, A.; Hougaard, D.; Nordentoft, M.; Mortensen, P. B.; Delaneau, O.; Werge, T.; Schork, A.
10.1101/2022.06.27.497703 — bioinformatics — Posted on 2022-06-29
291 Characterizing the landscape of viral expression in cancer by deep learning
Elbasir, A.; Ye, Y.; Schaffer, D. E.; Hao, X.; Wickramasinghe, J.; Lieberman, P. M.; Morris, Q. M.; Zhang, R.; Schaffer, A. A.; Auslander, N.
10.1101/2022.06.26.497658 — bioinformatics — Posted on 2022-06-29
292 MenDEL: PCR Primer Design as Constrained Optimization Process
German, S.; Mitchell, L.; Vela Gartner, A.; Fenyo, D.; Boeke, J. D.
10.1101/2022.06.26.496474 — bioinformatics — Posted on 2022-06-29
297 Probabilistic embedding and clustering with alignment for spatial transcriptomics data integration with PRECAST
Liu, W.; Liao, X.; Luo, Z.; Yang, Y.; Lau, M. C.; Jiao, Y.; Shi, X.; Zhai, W.; Ji, H.; Yeong, J.; Liu, J.
10.1101/2022.06.26.497672 — genomics — Posted on 2022-06-29
298 Chromosome level reference genome for European flat oyster (Ostrea edulis L.)
Gundappa, M. K.; Penaloza, C.; Regan, T.; Boutet, I.; Tanguy, A.; Houston, R. D.; Bean, T. P.; Macqueen, D. J.
10.1101/2022.06.26.497633 — genomics — Posted on 2022-06-29
299 Genotyping, sequencing and analysis of 140,000 adults from the Mexico City Prospective Study
Ziyatdinov, A.; Torres, J.; Alegre-Diaz, J.; Backman, J.; Mbatchou, J.; Turner, M.; Gaynor, S. M.; Joseph, T.; Zou, Y.; Liu, D.; Wade, R.; Staples, J.; Panea, R.; Popov, A.; Maxwell, E.; Jones, M.; Garcia-Ortiz, H.; Ramirez-Reyes, R.; Santacruz-Benitez, R.; Nag, A.; Smith, K. R.; Regeneron Genetics Center, ; Reppell, M.; Zollner, S.; Jorgenson, E.; Salerno, W.; Petrovski, S.; Overton, J.; Reid, J.; Thornton, T.; Abecasis, G.; Berumen, J.; Orozco-Orozco, L.; Collins, R.; Baras, A.; Hill, M. R.; Emberson, J. R.; Marchini, J.; Kuri-Morales, P.; Tapia-Conyer, R.
10.1101/2022.06.26.495014 — genetics — Posted on 2022-06-29
308 Detecting bat environmental DNA from water-filled road-ruts in upland forest
Marshall, N. T.; Symonds, D. E.; Walker, F. M.; Sanchez, D. E.; Couch, Z. L.; Kiser, J. D.
10.1101/2022.06.26.497664 — ecology — Posted on 2022-06-29
313 Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
Racle, J.; Guillaume, P.; Schmidt, J.; Michaux, J.; Larabi, A.; Lau, K.; Perez, M. A. S.; Croce, G.; Genolet, R.; Coukos, G.; Zoete, V.; Pojer, F.; Bassani-Sternberg, M.; Harari, A.; Gfeller, D.
10.1101/2022.06.26.497561 — immunology — Posted on 2022-06-29
314 Speech intelligibility changes the temporal evolution of neural speech tracking
Chen, Y.-P.; Schmidt, F.; Keitel, A.; Roesch, S.; Hauswald, A.; Weisz, N.
10.1101/2022.06.26.497639 — neuroscience — Posted on 2022-06-29
317 Insulin signaling and extended longevity in ants
Yan, H.; Opachaloemphan, C.; Carmona-Aldana, F.; Mancini, G.; Mlejnek, J.; Descostes, N.; Sieriebriennikov, B.; Leibholz, A.; Zhou, X.; Ding, L.; Traficante, M.; Desplan, C.; Reinberg, D.
10.1101/2022.06.25.497611 — physiology — Posted on 2022-06-29
319 Differential migration mechanics and immune responses of glioblastoma subtypes
Shamsan, G. A.; Liu, C. J.; Braman, B. C.; Rathe, S. K.; Sarver, A. L.; Ghaderi, N.; McMahon, M. M.; Klank, R. L.; Tschida, B. R.; McFarren, S. J.; Rosato, P. C.; Masopust, D.; Sarkaria, J. N.; Clark, H. B.; Rosenfeld, S. S.; Largaespada, D. A.; Odde, D. J.
10.1101/2022.06.26.497270 — cancer biology — Posted on 2022-06-29
320 Increased glycolysis and functional mitochondria fuel acinar-ductal metaplasia in the pancreas
Neuss, T.; Wirges, N.; Chen, M.-C.; Usluer, S.; Oellinger, R.; Lier, S.; Dudek, M.; Madl, T.; Jastroch, M.; Steiger, K.; Schmitz, W.; Einwaechter, H.; Schmid, R. M.
10.1101/2022.06.27.495427 — cancer biology — Posted on 2022-06-29
326 A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in allorecognition in Neurospora crassa
Glass, N. L.; Detomasi, T. C.; Rico Ramirez, A. M.; Sayler, R. I.; Goncalves, A. P.; Marletta, M. A.
10.1101/2022.06.26.497659 — genetics — Posted on 2022-06-29
327 Recognizability bias in citizen science photographs
Koch, W.; Hogeweg, L.; Nilsen, E. B.; O'Hara, R. B.; Finstad, A. G.
10.1101/2022.06.25.497604 — ecology — Posted on 2022-06-29
328 Artificial upwelling leads to a large increase in surface dissolved organic matter concentrations
Gomez-Letona, M.; Sebastian, M.; Banos, I.; Montero, M. F.; Perez Barrancos, C.; Baumann, M.; Riebesell, U.; Aristegui, J.
10.1101/2022.06.27.496799 — ecology — Posted on 2022-06-29
333 Dendrite branching receptor HPO-30 uses two novel mechanisms to regulate actin cytoskeletal remodeling
Kramer, D. A.; Narvaez-Ortiz, H. Y.; Shi, R.; Shen, K.; Roche, J.; Nolen, B. J.; Chen, B.
10.1101/2022.05.13.491788 — biochemistry — Posted on 2022-06-28
334 Distinguishing discrete and continuous behavioral variability using warped autoregressive HMMs
Costacurta, J. C.; Duncker, L.; Sheffer, B.; Gillis, W.; Weinreb, C.; Markowitz, J. E.; Datta, S. R.; Williams, A. H.; Linderman, S. W.
10.1101/2022.06.10.495690 — animal behavior and cognition — Posted on 2022-06-28
336 Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments
Shaffer, J. P.; Nothias, L.-F.; Thompson, L. R.; Jon, S. G.; Salido, R. A.; Couvillion, S. P.; Brejnrod, A. D.; Huang, S.; Lejzerowicz, F.; Haiminen, N.; Lutz, H. L.; Zhu, Q.; Martino, C.; Morton, J. T.; Karthikeyan, S.; Nothias-Esposito, M.; Dührkop, K.; Böcker, S.; Kim, H.; Aksenov, A. A.; Bittremieux, W.; Minich, J. J.; Marotz, C.; Bryant, M. M.; Sanders, K.; Schwartz, T.; Humphrey, G.; Vasquez-Baeza, Y.; Tripathi, A.; Parida, L.; Carrieri, A. P.; Beck, K. L.; Das, P.; Gonzalez, A.; McDonald, D.; Karst, S. M.; Albertsen, M.; Ackermann, G.; DeReus, J.; Thomas, T.; Petras, D.; Shade, A.; St
10.1101/2021.06.04.446988 — ecology — Posted on 2022-06-28
339 Target-agnostic discovery of Rett Syndrome therapeutics by coupling computational network analysis and CRISPR-enabled in vivo disease modeling
Novak, R.; Lin, T.; Kaushal, S.; Sperry, M. M.; Vigneault, F.; Gardner, E.; Loomba, S.; Shcherbina, K.; Keshari, V.; Dinis, A.; Vasan, A.; Chandrasekhar, V.; Takeda, T.; Turner, J. R.; Levin, M.; Ingber, D. E.
10.1101/2022.03.20.485056 — neuroscience — Posted on 2022-06-28
340 Active neural coordination of motor behaviors with internal states
Zhang, Y. S.; Takahashi, D. Y.; El Hady, A.; Liao, D. A.; Ghazanfar, A. A.
10.1101/2021.12.10.472142 — neuroscience — Posted on 2022-06-29
341 The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing
Ghram, M.; Morris, G.; Culjkovic-Kraljacic, B.; Mars, J. C.; Gendron, P.; Skrabanek, L.; Revuelta, M. V.; Cerchietti, L.; Guzman, M.; Borden, K.
10.1101/2021.12.07.471666 — cancer biology — Posted on 2022-06-28
342 Structural dynamics underlying gating and regulation in IP3R channel
Fan, G.; Baker, M. R.; Terry, L. E.; Arige, V.; Chen, M.; Seryshev, A.; Baker, M. L.; Ludtke, S. J.; Yule, D. I.; Serysheva, I. I.
10.1101/2022.05.27.493711 — biophysics — Posted on 2022-06-28
344 Chromosomal assembly of the flat oyster (Ostrea edulis L.) genome as a new genetic ressource for aquaculture
Boutet, I.; Monteiro, H. J. A.; Takeuchi, T.; Baudry, L.; Bonnivard, E.; Billoud, B.; Farhat, S.; Gonzales-Haraya, R.; Salaun, B.; Andersen, A.; Toullec, J.-Y.; Lallier, F.; Flot, J.-F.; Guiglielmoni, N.; Guo, X.; Cui, L.; Allam, B.; Pales-Espinoza, E.; Hemmer, J.; Marbouty, M.; Koszul, R.; Tanguy, A.
10.1101/2022.06.26.497643 — genomics — Posted on 2022-06-28
351 A Telltale Sign of Irreversibility in Transcriptional Regulation
Shelansky, R.; Abrahamsson, S.; Doody, M.; Brown, C. R.; Patel, H. P.; Lenstra, T. L.; Larson, D. R.; Boeger, H.
10.1101/2022.06.27.497819 — molecular biology — Posted on 2022-06-28
353 L-norepinephrine induces ROS formation but alters microbial community composition by altering cellular metabolism
Bains, A.; Dahal, S.; Manna, B.; Lyte, M.; Kolodziej, E. P.; Chaplen, F. W. R.; Yang, L.; Singhal, N.
10.1101/2022.06.28.482069 — microbiology — Posted on 2022-06-28
357 Massive accumulation of strontium and barium in diplonemid protists
Pilatova, J.; Tashyreva, D.; Tyc, J.; Vancova, M.; Bokhari, S. N. H.; Skoupy, R.; Klementov, M.; Kupper, H.; Mojzes, P.; Lukes, J.
10.1101/2022.06.27.497835 — microbiology — Posted on 2022-06-28
359 CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1
Jin, T.; Xu, Z.; Deng, S.; Huang, Y.; Yang, Y.; Sun, L.; Liu, H.; Zhao, D.; Zeng, W.; Yin, X.; Zheng, P.; Liu, M.; Zhao, W.; Zhou, Y.
10.1101/2022.06.26.497666 — immunology — Posted on 2022-06-28
363 Brain signal predictions from multi-scale networks using a linearized framework
Hagen, E.; Magnusson, S. H.; Ness, T. V.; Halnes, G.; Babu, P. N.; Linssen, C.; Morrison, A.; Einevoll, G. T.
10.1101/2022.02.28.482256 — neuroscience — Posted on 2022-06-28
364 Tissue specific LRRK2 interactomes reveal a distinct functional unit within the striatum
Zhao, Y.; Vavouraki, N.; Lovering, R. C.; Escott-Price, V.; Harvey, K.; Lewis, P. A.; Manzoni, C.
10.1101/2022.06.28.497918 — neuroscience — Posted on 2022-06-28
368 Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir
Hu, Y.; Lewandowski, E. M.; Tan, H.; Morgan, R. T.; Zhang, X.; Jacobs, L. M.; Butler, S. G.; Mongora, M. V.; Choy, J. S.; Chen, Y.; Wang, J.
10.1101/2022.06.28.497978 — pharmacology and toxicology — Posted on 2022-06-28
371 Heterologous reporter expression in the planarian Schmidtea mediterranea through somatic mRNA transfection
Hall, R. N.; Weill, U.; Drees, L.; Leal-Ortiz, S.; Li, H.; Chai, C.; Sanchez Alvarado, A.; Melosh, N. A.; Fire, A.; Rink, J. C.; Wang, B.
10.1101/2021.04.20.440701 — bioengineering — Posted on 2022-06-28
372 Nanocontainer derived from silkworm carotenoprotein for carotenoid extraction and presentation in biotechnology and biomedical applications
Sluchanko, N. N.; Slonimskiy, Y. B.; Egorkin, N. A.; Varfolomeeva, L. A.; Kleymenov, S. Y.; Minyaev, M. E.; Moysenovich, A. M.; Parshina, E. Y.; Friedrich, T.; Maksimov, E. G.; Boyko, K. M.; Popov, V. O.
10.1101/2022.06.28.497953 — biochemistry — Posted on 2022-06-28
376 Functional unknomics: closing the knowledge gap to accelerate biomedical research
Rocha, J.; Jayaram, S. A.; Stevens, T. J.; Muschalik, N.; Shah, R. D.; Emran, S.; Robles, C.; Freeman, M.; Munro, S.
10.1101/2022.06.28.497983 — molecular biology — Posted on 2022-06-28
379 Queuine salvaging in the human parasite Entamoeba histolytica
Sarid, L.; Sun, J.; Chittrakanwong, J.; Trebicz-Geffen, M.; Dedon, P.; Ankri, S.
10.1101/2022.06.21.496972 — microbiology — Posted on 2022-06-28
384 Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
Fan, C.; Cohen, A. A.; Park, M.; Hung, A. F.-H.; Keeffe, J. R.; Gnanapragasam, P. N.; Lee, Y. E.; Kakutani, L. M.; Wu, Z.; Malecek, K. E.; Williams, J. C.; Bjorkman, P. J.
10.1101/2022.06.28.497989 — immunology — Posted on 2022-06-28
388 Robust and Brain-Like Working Memory through Short-Term Synaptic Plasticity
Kozachkov, L.; Tauber, J.; Lundqvist, M.; Brincat, S. L.; Slotine, J.-J.; Miller, E. K.
10.1101/2022.01.09.475558 — neuroscience — Posted on 2022-06-28
397 Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic ductal adenocarcinoma
Zhang, W.; Wright, M.; Rathore, M.; Zarei, M.; Vaziri-Gohar, A.; Winter, J.; Brody, J.; Wang, R.
10.1101/2022.06.24.497507 — cancer biology — Posted on 2022-06-28
402 Expression Microdissection for use in qPCR based analysis of miRNA in a single cell type
Jenike, A. E.; Bunkelman, B.; Perzel Mandell, K. A.; Oduor, C.; Chin, D.; Mair, D.; Jenike, K. M.; Kim, D.-H.; Bailey, J. A.; Rafailovich, M. H.; Rosenberg, A. Z.; Halushka, M. K.
10.1101/2022.06.24.497524 — genomics — Posted on 2022-06-28
405 Extracellular vesicles carrying HIV-1 Nef induce trained immunity in myeloid cells
Dubrovsky, L.; Brichacek, B.; Prashant, N. M.; Pushkarsky, T.; Mukhamedova, N.; Dragoljevic, D.; Fitzgerald, M.; Horvath, A.; Murphy, A. J.; Sviridov, D.; Bukrinsky, M. I.
10.1101/2022.06.24.497538 — immunology — Posted on 2022-06-28
406 Reinstatement of emotional associations during human sleep: an intracranial EEG study
Legendre, G. Y. T.; Bayer, L.; Seeck, M.; Spinelli, L.; Schwartz, S.; Sterpenich, V.
10.1101/2022.06.24.497499 — neuroscience — Posted on 2022-06-28
410 Damage of Major South American Lepidopteran Soybean Pests
Carpane, P.; Llebaria, M.; Nascimento, A. F.; Vivan, L.
10.1101/2022.06.24.497488 — zoology — Posted on 2022-06-28
411 PhysiCell training apps: Cloud hosted open-source apps to learn cell-based simulation software
Sundus, A.; Kurtoglu, F.; Konstantinopoulos, K.; Chen, M.; Willis, D.; Heiland, R.; Macklin, P.
10.1101/2022.06.24.497566 — systems biology — Posted on 2022-06-28
414 The Pseudo-Torsional Space of RNA
Grille, L.; Gallego, D.; Darre, L.; da Rosa, G.; Battistini, F.; Orozco, M.; Dans, P. D.
10.1101/2022.06.24.497007 — bioinformatics — Posted on 2022-06-28
418 Between fishing and farming: palaeogenomic analyses reveal cross-cultural interactions triggered by the arrival of the Neolithic in the Danube Gorges
Hofmanova, Z.; Reyna-Blanco, C. S.; de Becdelievre, C.; Schulz, I.; Bloecher, J.; Jovanovic, J.; Winkelbach, L.; Figarska, S. M.; Schulz, A.; Porcic, M.; Kvetina, P.; Tsoupas, A.; Currat, M.; Buzhilova, A.; Gerritsen, F.; Karul, N.; McGlynn, G.; Orschiedt, J.; Oezbal, R.; Peters, J.; Ridush, B.; Terberger, T.; Teschler-Nicola, M.; Zarina, G.; Zeeb-Lanz, A.; Stefanovic, S.; Burger, J.; Wegmann, D.
10.1101/2022.06.24.497512 — genomics — Posted on 2022-06-28
421 Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice
Jeong, J. H.; Chokkakula, S.; Min, S. C.; Kim, B.; Choi, W.-S.; Oh, S.; Yun, Y. S.; Kang, D. H.; Lee, O.-J.; Kim, E.-G.; Choi, J.-H.; Lee, J.-Y.; Choi, Y. K.; Baek, Y. H.; Song, M.-S.
10.1101/2022.06.27.497875 — microbiology — Posted on 2022-06-28
422 Pre-existing immunity modulates responses to mRNA boosters
Dangi, T.; Sanchez, S.; Lew, M. H.; Visvabharathy, L.; Richner, J. M.; Koralnik, I.; Penaloza-MacMaster, P.
10.1101/2022.06.27.497248 — immunology — Posted on 2022-06-28
423 Cortical time-course of evidence accumulation during semantic processing
Ghazaryan, G.; van Vliet, M.; Lammi, L.; Lindh-Knuutila, T.; Kivisaari, S. L.; Hulten, A.; Salmelin, R.
10.1101/2022.06.24.497472 — neuroscience — Posted on 2022-06-28
424 Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2
Gahbauer, S.; Correy, G. J.; Schuller, M.; Ferla, M. P.; Doruk, Y. U.; Rachman, M.; Wu, T.; Diolaiti, M.; Wang, S.; Neitz, J.; Fearon, D.; Radchenko, D. S.; Moroz, Y.; Irwin, J. J.; Renslo, A. R.; Taylor, J. C.; Gestwicki, J. E.; von Delft, F.; Ashworth, A.; Ahel, I.; Shoichet, B. K.; Fraser, J. S.
10.1101/2022.06.27.497816 — biophysics — Posted on 2022-06-28
425 Activity-driven extracellular volume expansion drives vertebrate axis elongation
Michaut, A.; Mongera, A.; Gupta, A.; Serra, M.; Rigoni, P.; Lee, J. G.; Hall, A. R.; Duarte, F.; Mahadevan, L.; Guevorkian, K.; Pourquie, O.
10.1101/2022.06.27.497799 — developmental biology — Posted on 2022-06-28
428 The ribosome inhibitor chloramphenicol induces motility deficits in human spermatozoa: a proteomic approach identifies potentially involved proteins
Bisconti, M.; Leroy, B.; Gallagher, M. T.; Senet, C.; Martinet, B.; Arcolia, V.; Wattiez, R.; Kirkman-Brown, J.; Simon, J. F.; Hennebert, E.
10.1101/2022.06.28.496361 — cell biology — Posted on 2022-06-28
429 TCF4 trinucleotide repeat expansions and UV irradiation are associated with ferroptosis susceptibility in Fuchs endothelial corneal dystrophy
Saha, S.; Skeie, J. M.; Schmidt, G. A.; Eggleston, T.; Shevalye, H.; Sales, C. S.; Phruttiwanichakun, P.; Field, M.; Rinkoski, T. A.; Fautsch, M. P.; Baratz, K. H.; Roy, M.; Jun, A. S.; Salem, A. K.; Greiner, M. A.
10.1101/2022.06.27.497862 — cell biology — Posted on 2022-06-28
434 Mex67 paralogs mediate division of labor in trypanosome RNA processing and export.
Obado, S. O.; Stein, M.; Hegedusova, E.; Zhang, W.; Hutchinson, S.; Glover, L.; Paris, Z.; Chait, B. T.; Field, M. C.; Rout, M. P.
10.1101/2022.06.27.497849 — cell biology — Posted on 2022-06-28
437 Craniofacial dysmorphology in Down Syndrome is caused by increased dosage of Dyrk1a and at least three other genes
Redhead, Y.; Gibbins, D.; Lana-Elola, E.; Watson-Scales, S.; Dobson, L.; Krause, M.; Liu, K.; Fisher, E.; Green, J.; Tybulewicz, V.
10.1101/2022.06.27.497841 — developmental biology — Posted on 2022-06-28
442 Early visual cortex tracks speech envelope in the absence of visual input
Bednaya, E.; Mirkovic, B.; Berto, M.; Ricciardi, E.; Martinelli, A.; Federici, A.; Debener, S.; Bottari, D.
10.1101/2022.06.28.497713 — neuroscience — Posted on 2022-06-28
443 Transcriptomic and functional mapping of autism associated environmental factors in developing human neurons
Arora, A.; Becker, M.; Marques, C.; Oksanen, M.; Li, D.; Mastropasqua, F.; Watts, M. E.; Arora, M.; Falk, A.; Daub, C. O.; Lanekoff, I.; Tammimies, K.
10.1101/2022.06.27.497311 — neuroscience — Posted on 2022-06-28
445 Versatile live attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity
Yoshida, A.; Okamura, S.; Torii, S.; Komatsu, S.; Miyazato, P.; Ueno, S.; Suzuki, H.; Kamitani, W.; Ono, C.; Matsuura, Y.; Takekawa, S.; Yamanishi, K.; Ebina, H.
10.1101/2021.02.15.430863 — microbiology — Posted on 2022-06-28
448 Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-selective β-arrestin 2 knockout mice
Bitsi, S.; Manchanda, Y.; ElEid, L.; Mohamed, N.; Hansen, B.; Suba, K.; Rutter, G. A.; Salem, V.; Jones, B.; Tomas, A.
10.1101/2022.04.21.489075 — cell biology — Posted on 2022-06-28
450 Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
Hilander, T.; Monteuuis, G.; Awadhpersad, R.; Broda, K.; Pohjanpelto, M.; Pyman, E.; Singh, S. K.; Nyman, T. A.; Crevel, I.; Taylor, R. W.; Saada, A.; Balboa, D.; Battersby, B. J.; Jackson, C. B.; Carroll, C. J.
10.1101/2022.06.15.495910 — molecular biology — Posted on 2022-06-28
454 Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
Martino, J.; Siri, S. O.; Paviolo, N. S.; Garro, C.; Pansa, M. F.; Carbajosa, S.; Brown, A.; Bocco, J. L.; Gloger, I.; Drewes, G.; Madauss, K. P.; Soria, G.; Gottifredi, V.
10.1101/2022.06.24.497514 — cancer biology — Posted on 2022-06-28
455 Predictive Maps in Rats and Humans for Spatial Navigation
de Cothi, W.; Nyberg, N.; Griesbauer, E.-M.; Ghaname, C.; Zisch, F.; Fletcher, L.; Newton, C.; Renaudineau, S.; Bendor, D.; Grieves, R.; Duvelle, E.; Barry, C.; Spiers, H. J.
10.1101/2020.09.26.314815 — animal behavior and cognition — Posted on 2022-06-28
457 Models of the cardiac L-type calcium current: a quantitative review
Agrawal, A.; Wang, K.; Polonchuk, L.; Cooper, J.; Hendrix, M.; Gavaghan, D. J.; Mirams, G. R.; Clerx, M.
10.1101/2021.10.04.462988 — cell biology — Posted on 2022-06-28
458 The RNA demethylase FTO controls m6A marking on SARS-CoV-2 and classifies COVID-19 severity in patients
Malbec, L.; Celerier, M.; Bizet, M.; Calonne, E.; Hofmann-Winkler, H.; Boeckx, B.; Abdelnabi, R.; Putmans, P.; Hassabi, B.; Naesens, L.; Lambrechts, D.; Pöhlmann, S.; Deplus, R.; Delang, L.; Jeschke, J.; Fuks, F.
10.1101/2022.06.27.497749 — molecular biology — Posted on 2022-06-28
460 The discovery of genome-wide mutational dependence in naturally evolving populations
Green, A. G.; Vargas, R.; Marin, M. G.; Freschi, L.; Xie, J.; Farhat, M. R.
10.1101/2022.06.24.497504 — genomics — Posted on 2022-06-28
467 Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts
Suda, K.; Moriyama, Y.; Masukagami, Y.; Razali, N. B.; Chiu, Y.; Nishimura, K.; Barbee, H.; Takase, H.; Sugiyama, S.; Sato, Y.; Higashiyama, T.; Johmura, Y.; Nakanishi, M.; Kono, K.
10.1101/2021.03.26.437120 — cell biology — Posted on 2022-06-28
468 mb-PHENIX: Diffusion and Supervised Uniform Manifold Approximation for denoising microbiota data
Padron-Manrique, C.; Vazquez-Jimenez, A.; Esquivel-Hernandez, D. A.; Martinez-Lopez, Y. E.; Neri-Rosario, D.; Sanchez, J. P.; Giron-Villalobos, D.; Resendis-Antonio, O.
10.1101/2022.06.23.497285 — bioinformatics — Posted on 2022-06-28
471 A Telltale Sign of Irreversibility in Transcriptional Regulation
Shelansky, R.; Abrahamsson, S.; Doody, M.; Brown, C. R.; Patel, H. P.; Lenstra, T. L.; Larson, D. R.; Boeger, H.
10.1101/2022.06.27.497819 — molecular biology — Posted on 2022-06-27
476 Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis
Fan, L.; Gao, B.; Xu, Y.; Flynn, N.; Le, B.; You, C.; Li, S.; Achkar, N.; Manavellae, P. A.; Chen, X.
10.1101/2022.06.26.497656 — plant biology — Posted on 2022-06-27
478 Nanopore ion sources deliver single amino acid and peptide ions directly into high vacuum
Drachman, N.; LePoitevin, M.; Szapary, H.; Wiener, B.; Maulbetsch, W.; Stein, D.
10.1101/2021.08.15.456243 — biophysics — Posted on 2022-06-27
479 Low normal factor V enhances thrombin generation in hemophilia A through a substrate competition mechanism with factor Xa
Monroe, D. M.; Baird, C.; Peterson, J. A.; Mast, A. E.; Manco-Johnson, M.; Stobb, M.; Sindi, S.; Fogelson, A. L.; Leiderman, K.; Neeves, K.
10.1101/2022.06.27.496845 — biochemistry — Posted on 2022-06-27
482 Divergent evolution of early terrestrial fungi reveals the evolution of Mucormycosis pathogenicity factors
Wang, Y.; Chang, Y.; Ortanez, J.; Pena, J. F.; Carter-House, D.; Reynolds, N. K.; Smith, M. E.; Benny, G.; Mondo, S. J.; Salamov, A.; Lipzen, A.; Pangilinan, J.; Guo, J.; LaButti, K.; Andreopolous, W.; Tritt, A.; Keymanesh, K.; Yan, M.; Barry, K. W.; Grigoriev, I. V.; Spatafora, J. W.; Stajich, J. E.
10.1101/2022.06.24.497490 — evolutionary biology — Posted on 2022-06-27
483 Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle
Capovilla, G.; Braakman, R.; Fournier, G.; Hackl, T.; Schwartzman, J. A.; Lu, X.; Yelton, A.; Longnecker, K.; Soule, M. K.; Thomas, E.; Swarr, G.; Mongera, A.; Payette, J.; Waldbauer, J.; Kujawinski, E. B.; Cordero, O. X.; Chisholm, S. W.
10.1101/2022.06.23.497379 — ecology — Posted on 2022-06-27
486 Extravascular spaces are reservoirs of antigenic diversity in Trypanosoma brucei infection
Beaver, A.; Crilly, N. P.; Hakim, J.; Zhang, B.; Bobb, B.; Rijo-Ferreira, F.; Figueiredo, L. M.; Mugnier, M. R.
10.1101/2022.06.27.497797 — microbiology — Posted on 2022-06-27
487 Turicibacter modifies host bile acids and lipids in a strain-specific manner
Lynch, J. B.; Gonzalez, E. L.; Choy, K.; Faull, K. F.; Jewell, T.; Arellano, A.; Liang, J.; Yu, K. B.; Paramo, J.; Hsiao, E. Y.
10.1101/2022.06.27.497673 — microbiology — Posted on 2022-06-27
488 Structure-Uptake Relationship Studies of Oxazolidinones in Gram-negative ESKAPE Pathogens
Hu, Z.; Leus, I. V.; Chandar, B.; Sherborne, B.; Avila, Q. P.; RYBENKOV, V.; Zgurskaya, H. I.; Duerfeldt, A. S.
10.1101/2022.06.27.497815 — microbiology — Posted on 2022-06-27
489 Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA
Doritchamou, J. Y. A.; Nielsen, M. A.; Chene, A.; VIebig, N. K.; Lambert, L. E.; Sander, A. F.; Semblat, J.-P.; Hundt, S.; Orr-Gonzalez, S.; Janitzek, C. M.; Spiegel, A. J.; Clemmensen, S. B.; Thomas, M. L.; Nason, M. C.; Snow-Smith, M.; Barnafo, E. K.; Shiloach, J.; Chen, B. B.; Nadakal, S.; Highsmith, K.; Ouahes, T.; Conteh, S.; Sharma, A.; Torano, H.; Butler, B.; Reiter, K.; Rausch, K. M.; Scaria, P. V.; Anderson, C.; Narum, D. L.; Salanti, A.; Fried, M.; Theander, T. G.; Gamain, B.; Duffy, P. E.
10.1101/2022.06.24.497389 — immunology — Posted on 2022-06-27
490 Long-term effects of network-based fMRI neurofeedback training for sustained attention
Pamplona, G. S. P.; Heldner, J.; Langner, R.; Koush, Y.; Michels, L.; Ionta, S.; Garrido Salmon, C. E.; Scharnowski, F.
10.1101/2021.10.27.465722 — neuroscience — Posted on 2022-06-27
492 Spatial Transcriptomics-correlated Electron Microscopy
Androvic, P.; Schifferer, M.; Perez Anderson, K.; Cantuti-Castelvetri, L.; Ji, H.; Liu, L.; Besson-Girard, S.; Knoferle, J.; Simons, M.; Gokce, O.
10.1101/2022.05.18.492475 — neuroscience — Posted on 2022-06-27
493 Hippocampal cells multiplex positive and negative engrams
Shpokayte, M.; McKissick, O.; Yuan, B.; Rahsepar, B.; Fernandez, F. R.; Ruesch, E. A.; Grella, S. L.; White, J. A.; Liu, X. S.; Ramirez, S.
10.1101/2020.12.11.419887 — neuroscience — Posted on 2022-06-27
495 Functional network properties derived from widefield calcium imaging differ with wakefulness and across cell type
O'Connor, D.; Mandino, F.; Shen, X.; Horien, C.; Ge, X.; Herman, P.; Crair, M.; Papademetris, X.; Lake, E. M.; Constable, R. T.
10.1101/2022.05.24.493310 — neuroscience — Posted on 2022-06-27
498 Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes
Fialkoff, G.; Takahashi, N.; Sharkia, I.; Gutin, J.; Pongor, L.; Rajan, A.; Nichols, S.; Sciuto, L.; Vilimas, R.; Graham, C.; Desai, P.; Maoz, M.; Rottenberg, Y.; Shoshan, N.; Nechushtan, H.; Peretz, T.; Roame, D.; Carter, P.; Kumar, R.; Hubert, A.; Cohen, J. E.; Upadhyay, D.; Salah, A.; Temper, M.; Grinshpun, A.; Figg, W. D.; Zick, A.; Sadeh, R.; Friedman, N.; Thomas, A.
10.1101/2022.06.24.497386 — cancer biology — Posted on 2022-06-27
499 Protein k-mers enable assembly-free microbial metapangenomics
Reiter, T. E.; Pierce-Ward, N. T.; Irber, L. C.; Botvinnik, O.; Brown, C. T.
10.1101/2022.06.27.497795 — bioinformatics — Posted on 2022-06-27
502 Mer3 helicase protects early crossover intermediates from STR complex disassembly during meiosis
Altmannova, V.; Firlej, M.; Mueller, F.; Janning, P.; Rauleder, R.; Rousova, D.; Schaeffler, A.; Weir, J. R.
10.1101/2022.06.27.497840 — biochemistry — Posted on 2022-06-27
507 Dynamic DNA methylation contributes to carryover effects and beneficial acclimatization in geoduck clams
Putnam, H. M.; Trigg, S. A.; White, S. J.; Spencer, L. H.; Vadopalas, B.; Natarajan, A.; Hetzel, J.; Jaeger, E.; Soohoo, J.; Gallardo Escarate, C.; Goetz, F. W.; Roberts, S.
10.1101/2022.06.24.497506 — genomics — Posted on 2022-06-27
508 The slow evolving genome of the xenacoelomorph worm Xenoturbella bocki
Schiffer, P. H.; Natsidis, P.; Leite, D. J.; Robertson, H.; Lapraz, F.; Marletaz, F.; Fromm, B.; Baudry, L.; Simpson, F.; Hoye, E.; Zakrzewski, A.-C.; Kapli, P.; Hoff, K. J.; Mueller, S.; Marbouty, M.; Marlow, H.; Copley, R. H.; Sarkies, P.; Telford, M. J.
10.1101/2022.06.24.497508 — evolutionary biology — Posted on 2022-06-27
510 CROP-Seq: a single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes
Bielczyk-Maczynska, E.; Sharma, D.; Blencowe, M.; Saliba-Gustafsson, P.; Gloudemans, M. J.; Yang, X.; Carcamo-Orive, I.; Wabitsch, M.; Svensson, K. J.; Park, C. Y.; Quertermous, T.; Knowles, J. W.; Li, J.
10.1101/2022.06.27.497796 — molecular biology — Posted on 2022-06-27
511 Trajectories for the evolution of bacterial CO2-concentrating mechanisms
Flamholz, A. I.; Dugan, E. J.; Panich, J.; Desmarais, J. J.; Oltrogge, L. M.; Fischer, W. W.; Singer, S. W.; Savage, D. F.
10.1101/2022.06.21.497102 — microbiology — Posted on 2022-06-27
512 Newcastle disease burden in Nepal and efficacy of Tablet I-2 vaccine in commercial and backyard poultry production
Napit, R.; Poudel, A.; Pradhan, S.; Manandhar, P.; Ghaju, S.; Sharma, A. N.; Joshi, J.; Tha, S.; Dhital, K.; Rajbhandari, U.; Basnet, A.; Rajbhandari, R. M.; Schwind, J. S.; Karmacharya, D. B.
10.1101/2022.06.27.497727 — microbiology — Posted on 2022-06-27
514 Group B Streptococcus Adaptation Promotes Survival in a Hyper-inflammatory Diabetic Wound Environment
Keogh, R. A.; Haeberle, A. L.; Langouët-Astrie, C. J.; Kavanaugh, J. S.; Schmidt, E. P.; Moore, G. D.; Horswill, A. R.; Doran, K. S.
10.1101/2022.06.27.497804 — microbiology — Posted on 2022-06-27
515 Bimodal pilot study on inner speech decoding reveals the potential of combining EEG and fMRI
Simistira Liwicki, F.; Gupta, V.; Saini, R.; De, K.; Abid, N.; Rakesh, S.; Wellington, S.; Wilson, H.; Liwicki, M.; Eriksson, J.
10.1101/2022.05.24.492109 — neuroscience — Posted on 2022-06-27
516 Identification of a stress-sensitive anorexigenic neurocircuit from medial prefrontal cortex to lateral hypothalamus.
Clarke, R. E.; Voigt, K.; Reichenbach, A.; Stark, R.; Bharania, U.; Dempsey, H.; Lockie, S.; Mequinion, M.; Lemus, M. B.; Reed, F.; Rawlinson, S.; Nunez-Iglesias, J.; Foldi, C. J.; Kravitz, A. V.; Verdejo-Garcia, A.; Andrews, Z. B.
10.1101/2021.09.07.459350 — neuroscience — Posted on 2022-06-27
521 Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex
Muhleip, A.; Flygaard, R. K.; Haapanen, O.; Baradaran, R.; Gruhl, T.; Tobiasson, V.; Marechal, A.; Sharma, V.; Amunts, A.
10.1101/2022.06.26.497646 — biochemistry — Posted on 2022-06-27
527 Functional traits trade-offs define plant population stability worldwide
Conti, L.; Valencia, E.; Galland, T.; Götzenberger, L.; Leps, J.; E-Vojtko, A.; P. Carmona, C.; Majekova, M.; Danihelka, J.; Dengler, J.; Eldridge, D. J.; Estiarte, M.; Garcia-Gonzalez, R.; Garnier, E.; Gomez, D.; Hadincova, V.; Harrison, S. P.; Herben, T.; Ibanez, R.; Jentsch, A.; Juergens, N.; Kertesz, M.; Klumpp, K.; Krahulec, F.; Louault, F.; Marrs, R. H.; Onodi, G.; Pakeman, R. J.; Pärtel, M.; Peco, B.; Penuelas, J.; Rueda, M.; Schmidt, W.; Schmiedel, U.; Schuetz, M.; Skalova, H.; Smilauer, P.; Smilauerova, M.; Smit, C.; Song, M.; Stock, M.; Val, J.; Vandvik, V.; Ward, D.; Wesche, K.; W
10.1101/2022.06.24.497476 — ecology — Posted on 2022-06-27
530 ANTHRACNOSE RESISTANCE GENE2 confers fungal resistance in sorghum
Mewa, D. B.; Lee, S.; Liao, C.-J.; Souza, A. M.; Adeyanju, A.; Helm, M.; Lisch, D.; Mengiste, T.
10.1101/2022.06.24.497546 — plant biology — Posted on 2022-06-27
531 Are cell wall traits a component of the succulent syndrome?
Fradera-Soler, M.; Leverett, A.; Mravec, J.; Jorgensen, B.; Borland, A. M.; Grace, O. M.
10.1101/2022.06.25.497541 — plant biology — Posted on 2022-06-27
532 Genome of selfing Siberian Arabidopsis lyrata explains establishment of allopolyploid Arabidopsis kamchatica
Kolesnikova, U.; Scott, A. D.; Van de Velde, J. D.; Burns, R.; Tikhomirov, N. P.; Pfordt, U.; Clarke, A. C.; Yant, L.; Vekemans, X.; Laurent, S.; Novikova, P. Y.
10.1101/2022.06.24.497443 — plant biology — Posted on 2022-06-27
534 Biosphere functional integrity for people and Planet
Mohamed, A.; DeClerck, F.; Verburg, P.; Obura, D.; Abrams, J. F.; Zafra-Calvo, N.; Rocha, J. C.; Estrada-Carmona, N.; Fremier, A.; Jones, S. K.; Meier, I.; Sewart-Koster, B.
10.1101/2022.06.24.497294 — ecology — Posted on 2022-06-27
535 A natural definition for a bacterial strain and clonal complex
Rodriguez-R, L. M.; Conrad, R. E.; Feistel, D. J.; Viver, T.; Rossello-Mora, R.; Konstantinidis, K. T.
10.1101/2022.06.27.497766 — microbiology — Posted on 2022-06-27
536 Antiviral T-cell Biofactory platform for SARS-CoV-2
Ssemadaali, M. A.; Newmyer, S.; Radhakrishnan, H.; Arredondo, J.; Javitz, H. S.; Dandekar, S.; Bhatnagar, P.
10.1101/2022.06.26.497669 — synthetic biology — Posted on 2022-06-27
537 General dimensions of human brain morphometry inferred from genome-wide association data
Fürtjes, A. E.; Arathimos, R.; Coleman, J. R.; Cole, J. H.; Cox, S. R.; Deary, I. J.; de la Fuente, J.; Madole, J. W.; Tucker-Drob, E. M.; Ritchie, S. J.
10.1101/2021.10.22.465437 — genetics — Posted on 2022-06-27
541 RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity
Angioni, R.; Bonfanti, M.; Caporale, N.; Sanchez-Rodriguez, R.; Munari, F.; Savino, A.; Buratto, D.; Pagani, I.; Bertoldi, N.; Zanon, C.; Ferrari, P.; Ricciardelli, E.; Putaggio, C.; Ghezzi, S.; Elli, F.; Rotta, L.; Iorio, F.; Zonta, F.; Cattelan, A.; Vicenzi, E.; Molon, B.; Villa, C. E.; Viola, A.; Testa, G.
10.1101/2022.05.22.492693 — immunology — Posted on 2022-06-27
542 Correlating viscosity and molecular crowding with fluorescent nanobeads and molecular probes: in vitro and in vivo
Lecinski, S.; Shepherd, J. W.; Bunting, K.; Dresser, L.; Quinn, S. D.; MacDonald, C.; Leake, M. C.
10.1101/2022.06.27.497768 — biophysics — Posted on 2022-06-27
544 Benchmarking the Widely Used Structure-based Binding Affinity Predictors on the Spike-ACE2 Deep Mutational Interaction Set
Ozden, B.; Samiloglu, E.; Kosaca, M.; Oktayoglu, M.; Yukruk, C.; Erguven, M.; Arslan, N.; Karakulah, G.; Barlas, A. B.; Savas, B.; Karaca, E.
10.1101/2022.04.18.488633 — bioinformatics — Posted on 2022-06-27
548 Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells
Xu, J. H.; Yao, Y.; Yao, F.; Chen, J.; Li, M.; Yang, X.; Li, S.; Lu, F.; Hu, P.; He, S.; Peng, G.; Jing, N.
10.1101/2022.06.26.495599 — cell biology — Posted on 2022-06-27
550 Cellular aging impedes stress-activation of a crucial JDP-Hsp70 protein disaggregase
Mathangasinghe, Y.; Alberts, N.; Rosado, C. J.; Cox, D.; Payne, N. L.; Ormsby, A. R.; Alp, K. M.; Sakson, R.; Uthishtran, S.; Ruppert, T.; Arumugam, S.; Hatters, D. M.; Kampinga, H. H.; Nillegoda, N. B.
10.1101/2022.06.25.497591 — cell biology — Posted on 2022-06-27
555 Parallel evolution of amphioxus and vertebrate small-scale gene duplications
Braso-Vives, M.; Marletaz, F.; Echchiki, A.; Mantica, F.; Acemel, R. D.; Gomez-Skarmeta, J. L.; Targa, L. L.; Pontarotti, P.; Tena, J. J.; Maeso, I.; Escriva, H.; Irimia, M.; Robinson-Rechavi, M.
10.1101/2022.01.18.476203 — evolutionary biology — Posted on 2022-06-27
557 Multi-omics analysis reveals a crucial role for Retinoic Acid in promoting epigenetic and transcriptional competence of an in vitro model of human Pharyngeal Endoderm.
Cipriano, A.; Colantoni, A.; Gomes, D.; Moqri, M.; Parker, A.; Caldwell, M.; Briganti, F.; Fiorentino, J.; Roncarolo, M. G.; Baldini, A.; Weinacht, K. G.; Tartaglia, G. G.; Sebastiano, V.
10.1101/2022.06.26.497457 — developmental biology — Posted on 2022-06-27
558 A DNase T6SS effector requires its MIX domain for secretion
Fridman, C. M.; Jana, B.; Ben-Yaakov, R.; Bosis, E.; Salomon, D.
10.1101/2022.05.04.489851 — microbiology — Posted on 2022-06-27
559 Auxin-dependent acceleration of cell division rates regulates root growth at elevated temperature
Ai, H.; Bellstaedt, J.; Bartusch, K. S.; Eschen-Lippold, L.; Babben, S.; Balcke, G. U.; Tissier, A.; Hause, B.; Andersen, T. G.; Delker, C.; Quint, M.
10.1101/2022.06.22.497127 — plant biology — Posted on 2022-06-27
561 Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)
Fuandila, N. N.; Gosselin-Grenet, A.-S.; Tilak, M.-K.; Bergmann, S. M.; Escoubas, J.-M.; Klafack, S.; Lusiastuti, A. M.; Yuhana, M.; Fiston-Lavier, A.-S.; Avarre, J.-C.; Cherif, E.
10.1101/2022.03.10.483410 — genomics — Posted on 2022-06-27
562 AvP: a software package for automatic phylogenetic detection of candidate horizontal gene transfers.
Koutsovoulos, G. D.; Granjeon Noriot, S.; Bailly-Bechet, M.; Danchin, E. G. J.; Rancurel, C.
10.1101/2022.06.23.497291 — bioinformatics — Posted on 2022-06-27
566 Plasmid manipulation of bacterial behaviour through translational regulatory crosstalk
Thompson, C.; Hall, J.; Chandra, G.; Martins, C.; Saalbach, G.; Bird, S.; Ford, S.; Little, R.; Piazza, A.; Harrison, E.; Jackson, R.; Brockhurst, M.; Malone, J.
10.1101/2022.06.27.497698 — microbiology — Posted on 2022-06-27
567 Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5
Wang, Q.; Guo, Y.; Iketani, S.; Li, Z.; Mohri, H.; Wang, M.; Yu, J.; Bowen, A. D.; Chan, J. Y.; Shah, J. G.; Nguyen, N.; Chen, Z.; Meyers, K.; Yin, M. T.; Sobieszczyk, M. E.; Sheng, Z.; Huang, Y.; Liu, L.; Ho, D.
10.1101/2022.05.26.493517 — microbiology — Posted on 2022-06-27
568 Unsupervised genome-wide cluster analysis: nucleotide sequences of the omicron variant of SARS-CoV-2 are similar to sequences from early 2020
Hahn, G.; Lee, S.; Prokopenko, D.; Novak, T.; Hecker, J.; Khurana, S.; Baden, L. R.; Randolph, A. G.; Weiss, S. T.; Lange, C.
10.1101/2021.12.29.474469 — bioinformatics — Posted on 2022-06-27
569 Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest
Hahn, G.; Lee, S.; Prokopenko, D.; Abraham, J.; Novak, T.; Hecker, J.; Cho, M.; Khurana, S.; Baden, L. R.; Randolph, A. G.; Weiss, S. T.; Lange, C.
10.1101/2022.05.16.492178 — bioinformatics — Posted on 2022-06-27
570 Human RAD52 stimulates the RAD51-mediated homology search
Muhammad, A. A.; Peterlini, T.; Guirouilh-Barbat, J.; Veaute, X.; Busso, D.; Lopez, B.; Masson, J.-Y.; Mazon, G.; Le Cam, E.; Dupaigne, P.
10.1101/2022.06.27.497340 — biochemistry — Posted on 2022-06-27
573 Preclinical model for the study of immune responses specific for a hepatic self-antigen
Cardon, A.; Judor, J.-P.; Guinebretiere, T.; Danger, R.; Nicot, A.; Brouard, S.; Conchon, S.; Renand, A.
10.1101/2022.06.22.497185 — immunology — Posted on 2022-06-27
574 Toxicity of House Cricket (Acheta domesticus) in Mice
Matano, Y.; Sakagami, K.; Nojiri, Y.; Nomura, K.; Masuda, A.; Moriike, Y.; Yamamoto, A.; Nagai, N.; Ogura, A.
10.1101/2022.06.23.497304 — pharmacology and toxicology — Posted on 2022-06-27
575 Equilibrium dynamics of a biomolecular complex analyzed at single-amino acid resolution by cryo-electron microscopy
Luque, D.; Ortega-Esteban, A.; Valbuena, A.; Vilas, J. L.; Rodriguez-Huete, A.; Mateu, M.; Caston, J. R.
10.1101/2022.06.24.497460 — biophysics — Posted on 2022-06-27
580 Auxin-dependent acceleration of cell division rates regulates root growth at elevated temperature
Ai, H.; Bellstaedt, J.; Bartusch, K. S.; Eschen-Lippold, L.; Babben, S.; Balcke, G. U.; Tissier, A.; Hause, B.; Andersen, T. G.; Delker, C.; Quint, M.
10.1101/2022.06.22.497127 — plant biology — Posted on 2022-06-27
583 Enhancing associative learning in rats with a computationally designed training protocol
Zhang, X. O.; Zhang, Y.; Engelke, D. S.; Cho, C. E.; Smolen, P.; Byrne, J. H.; Do Monte, F. H.
10.1101/2022.06.08.495364 — neuroscience — Posted on 2022-06-27
584 Single molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing
Lau, B. T.; Almeda, A.; Schauer, M.; McNamara, M.; Bai, X.; Meng, Q.; Partha, M.; Grimes, S. M.; Lee, H.; Heestand, G. M.; Ji, H. P.
10.1101/2022.06.22.497080 — genomics — Posted on 2022-06-26
585 Dominant toxin hypothesis: unravelling the venom phenotype across micro and macroevolution
Smith, E. G.; Surm, J. M.; Macrander, J.; Simhi, A.; Amir, G.; Sachkova, M. Y.; Lewandowska, M.; Reitzel, A. M.; Moran, Y.
10.1101/2022.06.22.497252 — evolutionary biology — Posted on 2022-06-26
586 An Atlas of Cells in the Human Tonsil
Massoni-Badosa, R.; Soler-Vila, P.; Aguilar-Fernandez, S.; Nieto, J. C.; Elosua-Bayes, M.; Marchese, D.; Kulis, M.; Vilas-Zornoza, A.; Bühler, M. M.; Rashmi, S.; Alsinet, C.; Caratu, G.; Moutinho, C.; Ruiz, S.; Lorden, P.; Lunazzi, G.; Colomer, D.; Frigola, G.; Blevins, W.; Palomino, S.; Gomez-Cabrero, D.; Aguirre, X.; Weniger, M. A.; Marini, F.; Cervera-Paz, F. J.; Baptista, P. M.; Vilaseca, I.; Prosper, F.; Küppers, R.; Gut, I. G.; Campo, E.; Martin-Subero, J. I.; Heyn, H.
10.1101/2022.06.24.497299 — immunology — Posted on 2022-06-26
587 The Intrinsic Hierarchy of Self - Converging Topography and Dynamics
Catal, Y.; Gunay, M. A.; Li, C.; Wang, J.; Cui, H.; Li, W.; Northoff, G.
10.1101/2022.06.23.497287 — neuroscience — Posted on 2022-06-26
589 Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell disease
Metaferia, B.; Cellmer, T.; Dunkerlberger, E. B.; Li, Q.; Henry, E. R.; Hofrichter, J.; Staton, D.; Hsieh, M. M.; Conrey, A. K.; Tisdale, J. F.; Chatterjee, A. K.; Thein, S. L.; Eaton, W. A.
10.1101/2022.06.23.497377 — pharmacology and toxicology — Posted on 2022-06-26
591 Aging impairs the clustering and reduces the activity of L-type calcium channels in cardiac pacemaker cells
Baudot, M.; Vivas, O.; Choi, S.; Serrano, G.; Flores, V. A.; Santana, L. F.; Moreno, C. M.
10.1101/2022.06.22.497267 — biophysics — Posted on 2022-06-26
593 Verkko: telomere-to-telomere assembly of diploid chromosomes
Rautiainen, M.; Nurk, S.; Walenz, B. P.; Logsdon, G. A.; Porubsky, D.; Rhie, A.; Eichler, E. E.; Phillippy, A. M.; Koren, S.
10.1101/2022.06.24.497523 — bioinformatics — Posted on 2022-06-26
595 Epistasis between promoter activity and coding mutations shapes gene evolvability
Caballero, A. F. C.; Gagnon-Arsenault, I.; Dube, A. K.; Despres, P. C.; Kumar, P.; Lafontaine, K.; Pelletier, J. N.; Landry, C. R.
10.1101/2022.06.07.495002 — evolutionary biology — Posted on 2022-06-26
596 BeeDNA: microfluidic environmental DNA metabarcoding as a tool for connecting plant and pollinator communities
Harper, L. R.; Niemiller, M. L.; Benito, J.; Paddock, L. E.; Knittle, E.; Molano-Flores, B.; Davis, M. A.
10.1101/2021.11.11.468290 — ecology — Posted on 2022-06-26
598 Generation of functional hepatocytes by forward programming with nuclear receptors
Tomaz, R. A.; Zacharis, E. D.; Bachinger, F.; Wurmser, A.; Yamamoto, D.; Petrus-Reurer, S.; Morell, C. M.; Dziedzicka, D.; Wesley, B. T.; Geti, I.; Segeritz, C.-P.; de Brito, M. C.; Chhatriwala, M.; Ortmann, D.; Saeb-Parsy, K.; Vallier, L.
10.1101/2022.06.23.497371 — developmental biology — Posted on 2022-06-26
599 Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum
Raghavan, M.; Kalantar, K. L.; Duarte, E.; Teyssier, N.; Takahashi, S.; Kung, A. F.; Rajan, J. V.; Rek, J.; Tetteh, K. K. A.; Drakeley, C.; Ssewanyana, I.; Rodriguez-Barraquer, I.; Greenhouse, B.; DeRisi, J. L.
10.1101/2022.06.24.497532 — immunology — Posted on 2022-06-26
606 Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis
Fan, L.; Gao, B.; Flynn, N.; Xu, Y.; Le, B.; You, C.; Li, S.; Achkar, N.; Manavellae, P. A.; Chen, X.
10.1101/2022.06.26.497656 — plant biology — Posted on 2022-06-26
608 Assessing Functional Androgen Receptor Pathway Activity in Response to Radiotherapy Using hK2-targeted PET Imaging
Storey, C. M.; Altai, M.; Bicak, M.; Veach, D. R.; Lueckerath, K.; Adrian, G.; McDevitt, M. R.; Kalidindi, T.; Park, J. E.; Herrmann, K.; Abou, D.; Zedan, W.; Peekhaus, N.; Klein, R. J.; Damoiseaux, R.; Larson, S. M.; Lilija, H.; Thorek, D.; Thorek, D. L.; Ulmert, D.
10.1101/2022.06.23.497290 — cancer biology — Posted on 2022-06-26
609 Adrenal cortex size, homeostasis and tumorigenesis is regulated by gonadal hormones via androgen receptor/β-catenin signalling crosstalk.
Lyraki, R.; Grabek, A.; Tison, A.; Peitzsch, M.; Bechmann, N.; Youssef, S.; de Bruin, A.; Bakker, E.; Claessens, F.; Chaboissier, M.-C.; Schedl, A.
10.1101/2022.06.23.497219 — cancer biology — Posted on 2022-06-26
613 Genomic characterisation of a novel species of Erysipelothrix associated with mortalities among endangered seabirds
Zhong, J.; Medvecky, M.; Tornos, J.; Clessin, A.; Gantelet, H.; Gamble, A.; Forde, T. L.; Boulinier, T.
10.1101/2022.06.23.497316 — genomics — Posted on 2022-06-26
616 Estimating the maximal growth rates of eukaryotic microbes from cultures and metagenomes via codon usage patterns
Weissman, J.; Dimbo, E.-R. O.; Krinos, A. I.; Neely, C.; Yagues, Y.; Nolin, D.; Hou, S.; Laperriere, S.; Caron, D. A.; Tully, B. L.; Alexander, H.; Fuhrman, J. A.
10.1101/2021.10.15.464604 — microbiology — Posted on 2022-06-26
617 Myeloid reprogramming by JAK inhibition enhances checkpoint blockade therapy
Zak, J.; Pratumchai, I.; Marro, B. S.; Marquardt, K. L.; Beheshti Zavareh, R.; Lairson, L. L.; Oldstone, M. B. A.; Varner, J. A.; Bachanova, V.; Teijaro, J.
10.1101/2022.06.24.497435 — immunology — Posted on 2022-06-26
618 Early life tolerance depends on a subset of specialized dendritic cells and is reinforced by the skin microbiota
Weckel, A. A.; Dhariwala, M. O.; Ly, K.; Ojewumi, O. T.; Riggs, J. B.; Gonzalez, J. R.; Dwyer, L. R.; Okoro, J. N.; Leech, J. M.; Bacino, M. S.; Cho, G. D.; merana, G.; Anandasabapathy, N.; Kumamoto, Y. O.; Scharschmidt, T. C.
10.1101/2022.06.23.497363 — immunology — Posted on 2022-06-26
619 Aromatase Inhibitor Induced Musculoskeletal Inflammation is Observed Independent of Oophorectomy in a Novel Mouse Model
Young, N. A.; Hampton, J.; Sharma, J.; Jablonski, K.; DeVries, A. C.; Bratasz, A.; Wu, L.-C.; Lustberg, M.; Reinbolt, R.; Jarjour, W. N.
10.1101/2022.06.22.497263 — immunology — Posted on 2022-06-26
620 Explicitly Nonlinear Dynamic Functional Network Connectivity In Resting-State fMRI Data
Motlaghian, S.; Belger, A.; Bustillo, J.; Ford, J.; Iraji, A.; Lim, K.; Mathalon, D.; Mueller, B.; O'Leary, D.; Pearlson, G.; Potkin, S.; Preda, A.; van Erp, T.; Calhoun, V.
10.1101/2022.06.22.497262 — neuroscience — Posted on 2022-06-26
622 The tau oligomer antibody APNmAb005 detects early-stage pathological tau enriched at synapses and rescues neuronal loss in long-term treatments
Tai, H.-C.; Ma, H.-T.; Huang, S.-C.; Wu, M.-F.; Wu, C.-L.; Lai, Y.-T.; Li, Z.-L.; Margolin, R.; Intorcia, A. J.; Serrano, G. E.; Beach, T. G.; Nallani, M.; Navia, B.; Jang, M.-K.; Tai, C.-Y.
10.1101/2022.06.24.497452 — neuroscience — Posted on 2022-06-26
623 Primate neocortex performs balanced sensory amplification
Pattadkal, J. J.; Zemelman, B. V.; Fiete, I.; Priebe, N. J.
10.1101/2022.06.23.497220 — neuroscience — Posted on 2022-06-26
626 A potential marker for problematic mother-infant bonding revealed by magnetoencephalography study of first-time mothers listening to infant cries
Hoegholt, N. F.; Bonetti, L. F.; Stevner, A.; Andersen, C. E.; Hughes, M.; Fernandes, H.; Vuust, P.; Kringelbach, M. L.
10.1101/2022.06.24.497467 — neuroscience — Posted on 2022-06-26
627 Gender and comorbidity moderate the relationship between mood disorder symptoms and effortful avoidance performance
Forys, B. J.; Tomm, R. J.; Stamboliyska, D.; Terpstra, A. R.; Clark, L.; Chakrabarty, T.; Floresco, S. B.; Todd, R. M.
10.1101/2022.06.21.497075 — neuroscience — Posted on 2022-06-26
629 The Vacc-SeqQC Project: Benchmarking RNA-Seq for Clinical Vaccine Studies
Goll, J. B.; Bosinger, S. E.; Jensen, T. L.; Walum, H.; Grimes, T.; Tharp, G. D.; Natrajan, M. S.; Blazevic, A.; Heada, R.; Gelber, C. E.; Patel, N. B.; Sanz, P.; Rouphael, N. G.; Anderson, E. J.; Mulligan, M. J.; Hoft, D. F.
10.1101/2022.06.23.497396 — systems biology — Posted on 2022-06-26
632 RAS-induced transformation of mammary epithelial cells relies on ZEB1-dependent cellular reprogramming via a paracrine process
De Blander, H.; Tonon, L.; Fauvet, F.; Pommier, R. M.; Lamblot, C.; Benhassoun, R.; Angileri, F.; Gibert, B.; Ouzounova, M.; Morel, A.-P.; Puisieux, A.
10.1101/2022.06.23.497180 — cancer biology — Posted on 2022-06-26
635 Improving Mathematical Models of Cancer throughGame-Theoretic Modelling: A Study in Non-SmallCell Lung Cancer
Ardevol Martinez, V.; Ghaffari Laleh, N.; Salvioli, M.; Thuijsman, F.; Brown, J. S.; Cavill, R.; Kather, J. N.; Stankova, K.
10.1101/2021.10.29.466444 — cancer biology — Posted on 2022-06-26
636 ResMiCo: increasing the quality of metagenome-assembled genomes with deep learning
Mineeva, O.; Danciu, D.; Schoelkopf, B.; Ley, R. E.; Raetsch, G.; Youngblut, N. D.
10.1101/2022.06.23.497335 — bioinformatics — Posted on 2022-06-26
639 MB-SupCon: Microbiome-based predictive models via Supervised Contrastive Learning
Yang, S.; Wang, S.; Wang, Y.; Rong, R.; Kim, J.; Li, B.; Koh, A. Y.; Xiao, G.; Li, Q.; Liu, D.; Zhan, X.
10.1101/2022.06.23.497232 — bioinformatics — Posted on 2022-06-26
640 WiNGS: Widely integrated NGS platform for federated genome analysis
Chizari, H.; Sattanathan, N.; Ardeshirdavani, A.; Shabani, N.; Huremagic, B.; Vermeesch, J. R.; Moreau, Y.; Vandeweyer, G.
10.1101/2022.06.23.497325 — bioinformatics — Posted on 2022-06-26
641 StORF-Reporter: Finding Genes between Genes
Dimonaco, N. J.; Aubrey, W.; Kenobi, K.; Clare, A.; Creevey, C. J.
10.1101/2022.03.31.486628 — bioinformatics — Posted on 2022-06-26
646 Human blastoid from primed human embryonic stem cells
Imamura, S.; Wen, X.; Terada, S.; Yamamoto, A.; Mutsuda-Zapater, K.; Sawada, K.; Yoshimoto, K.; Tanaka, M.; Kamei, K.-i.
10.1101/2022.06.23.497328 — bioengineering — Posted on 2022-06-26
648 Single-shot Volumetric Chemical Imaging by Mid- Infrared Photothermal Fourier Light Field Microscopy
zhang, y.; Jia, D.; Yang, Q.; Xue, Y.; Tan, Y.; Guo, Z.; Zhang, M.; Tian, L.; Cheng, J.-X.
10.1101/2022.06.24.497516 — biochemistry — Posted on 2022-06-26
651 Genetic landscape of Human neutrophil antigen variants in India from population-scale genomes
Rophina, M.; Bhoyar, R. C.; Imran, M.; Senthivel, V.; Divakar, M. K.; Mishra, A.; Jolly, B.; Sivasubbu, S.; Scaria, V.
10.1101/2022.06.23.497282 — genomics — Posted on 2022-06-26
652 The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1
Corfield, E. C.; Frei, O.; Shadrin, A. A.; Rahman, Z.; Lin, A.; Athanasiu, L.; Cevdet Akdeniz, B.; Hannigan, L.; Wootton, R. E.; Austerberry, C.; Hughes, A.; Tesli, M.; Westlye, L. T.; Stefansson, H.; Stefansson, K.; Njolstad, P. R.; Magnus, P.; Davies, N. M.; Appadurai, V.; Hemani, G.; Hovig, E.; Zayats, T.; Ask, H.; Reichborn-Kjennerud, T.; Andreassen, O. A.; Havdahl, A.
10.1101/2022.06.23.496289 — genetics — Posted on 2022-06-26
654 Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe
Pai, C.-C.; Heitzer, E.; Bertrand, S.; Toumazou, S.; Humphrey, T.; Kearsey, S.
10.1101/2022.06.23.497361 — genetics — Posted on 2022-06-26
655 Adaptation to a changing environment: what me Normal?
Garnier, J.; Cotto, O.; Bourgeron, T.; Bouin, E.; Lepoutre, T.; Ronce, O.; Calvez, V.
10.1101/2022.06.22.497192 — evolutionary biology — Posted on 2022-06-26
658 The cynosure of CtBP: evolution of a bilaterian transcriptional corepressor
Raicu, A.-M.; Kadiyala, D.; Niblock, M.; Jain, A.; Yang, Y.; Bird, K. M.; Bertholf, K.; Seenivasan, A.; Arnosti, D. N.
10.1101/2022.06.23.497424 — evolutionary biology — Posted on 2022-06-26
665 Mechanoregulatory role of TRPV4 in prenatal skeletal development
Khatib, N. S.; Monsen, J.; Ahmed, S.; Huang, Y.; Hoey, D. A.; Nowlan, N. C.
10.1101/2022.06.23.497086 — developmental biology — Posted on 2022-06-26
670 Zinc arrests axonal transport and displaces tau, doublecortin, and MAP2C from microtubules
Minckley, T. F.; Salvagio, L. A.; Fudge, D. H.; Verhey, K.; Markus, S. M.; Qin, Y.
10.1101/2021.12.02.470968 — cell biology — Posted on 2022-06-26
671 NHR-23 activity is necessary for developmental progression and apical extracellular matrix structure and function
Johnson, L. C.; Vo, A. A.; Clancy, J. C.; Aguilera, J. D.; Levenson, M. T.; Wohlenberg, C.; Rechtsteiner, A. D.; Ragle, J. M.; Ward, J. D.
10.1101/2021.10.27.465992 — molecular biology — Posted on 2022-06-26
673 The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling
Sandner, L.; Alteneder, M.; Rica, R.; Woller, B.; Sala, E.; Frey, T.; Tosevska, A.; Zhu, C.; Madern, M.; Hoffmann, P.; Schebesta, A.; Taniuchi, I.; Bonelli, M.; Schmetterer, K.; Iannacone, M.; Kuka, M.; Ellmeier, W.; Sakaguchi, S.; Herbst, R.; Boucheron, N.
10.1101/2022.06.23.497284 — immunology — Posted on 2022-06-26
674 T-cell potential for CD19-expressing malignancies revealed by multi-dimensional single-cell profiling
Rezvan, A.; Romain, G.; Fathi, M.; Heeke, D.; Martinez-Paniagua, M.; An, X.; Bandey, I. N.; Saeedi, A.; Sadeghi, F.; Fousek, K.; Puebla-Osorio, N.; Cooper, L. J.; Bernatchez, C.; Singh, H.; Ahmed, N.; Mattie, M.; Bot, A.; Neelapu, S.; Varadarajan, N.
10.1101/2022.06.22.497245 — immunology — Posted on 2022-06-26
675 Novel populations of CD4+ T cells associated with vaccine efficacy
Woodring, T.; Dewey, C. N.; Dos Santos Dias, L.; He, X.; Dobson, H. E.; Wuethrich, M.; klein, b. s.
10.1101/2022.06.23.497400 — immunology — Posted on 2022-06-26
681 Radiochemical Synthesis and Evaluation of 3-methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS
Sun, Y.; Guehl, N. J.; Zhou, Y.-P.; Takahashi, K.; Belov, V.; Dhaynaut, M.; Moon, S.-H.; Fakhri, G. E.; Normandin, M. D.; Brugarolas, P.
10.1101/2022.06.22.495540 — neuroscience — Posted on 2022-06-26
683 Thermal Pain and Detection Threshold Modulation in Augmented Reality
Eckhoff, D.; Sandor, C.; Cheing, G. L. Y.; Schnupp, J.; Cassinelli, A.
10.1101/2022.06.22.497278 — neuroscience — Posted on 2022-06-26
685 Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress
Bordes, J.; Miranda, L.; Reinhardt, M.; Brix, L. M.; van Doeselaar, L.; Engelhardt, C.; Puetz, B.; Agakov, F.; Mueller-Myhsok, B.; Schmidt, M. V.
10.1101/2022.06.23.497350 — neuroscience — Posted on 2022-06-26
690 Penetratin inhibits α-synuclein fibrillation and improves locomotor functions in mice model of Parkinsons disease
Gupta, A.; Singh, P.; Mehrotra, A.; Gautam, A.; Srividya, K.; Panigrahi, R.; Vashishtha, S.; Singh, J.; Jaiswal, G.; Upadhayay, K.; Frank, S. A.; Nielsen, J.; Nath, S. K.; Khatri, N.; Otzen, D. E.; Raghava, G. P. S.; Koul, A.; Kundu, B.; Kumar, A.; Nazir, A.; Sharma, D.
10.1101/2022.06.24.497475 — neuroscience — Posted on 2022-06-26
694 Integrated Regulation of Dopaminergic and Epigenetic Effectors of Neuroprotection in Parkinson's Disease Models
Nourse, J. B.; Russell, S. N.; Moniz, N. A.; Scott, M.; Park, H.-A.; Caldwell, K. A.; Caldwell, G. A.
10.1101/2022.06.21.497090 — neuroscience — Posted on 2022-06-26
696 Deep brain cancer metastasis detection with wide-volume Raman spectroscopy through a single tapered fiber
Pisano, F.; Masmudi Martin, M.; Andriani, M. S.; Cid, E.; Pisanello, M.; Balena, A.; Collard, L. J.; Tantussi, F.; Grande, M.; Sileo, L.; Gentile, F.; De Angelis, F.; De Vittorio, M.; de la Prida, L. M.; Valiente, M.; Pisanello, F.
10.1101/2022.06.24.497456 — neuroscience — Posted on 2022-06-26
699 Reconstructing the functional effect of TP53 somatic mutations on its regulon using causal signalling network modelling
Triantafyllidis, C.; Barberis, A.; Miar, A.; Chartlon, P.; Hartley, F.; Van Bijsterveldt, L.; Gjerga, E.; Saez-Rodriguez, J.; Buffa, F. M.
10.1101/2022.06.23.497293 — systems biology — Posted on 2022-06-26
704 Chronic inflammation suppresses del(5q)-like MDS HSCs via p53
Muto, T.; Walker, C.; Choi, K.; Niederkorn, M.; Ishikawa, C.; Varney, M.; Hueneman, K.; Starczynowski, D. T.
10.1101/2022.06.22.497183 — cancer biology — Posted on 2022-06-26
712 mb-PHENIX: Diffusion and Supervised Uniform Manifold Approximation for denoising microbiota data
Padron-Manrique, C.; Giron-Villalobos, D.; Sanchez, J. P.; Neri-Rosario, D.; Martinez-Lopez, Y. E.; Esquivel-Hernandez, D. A.; Resendis-Antonio, O.
10.1101/2022.06.23.497285 — bioinformatics — Posted on 2022-06-26
714 A unified peptide array platform for antibody epitope binning, mapping, specificity and predictive off-target binding
Moore, C.; Lei, A.; Walsh, P.; Trenchevska, O.; Saini, G.; Tarasow, T. M.; Srinivasan, M.; Smith, D.; Greving, M. P.
10.1101/2022.06.22.497251 — bioengineering — Posted on 2022-06-26
716 Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure --predictors of blood damage and clotting
Scotten, L. N.; Siegel, R.; Blundon, D. J.; Deutsch, M.-A.; Martin, T. R. P.; Dutton, J. W.; Kolahdouz, E. M.; Griffith, B. E.
10.1101/2022.06.23.497372 — bioengineering — Posted on 2022-06-26
719 Evolutionary divergence in sugar valuation shifts Drosophila suzukii oviposition choice towards ripe fruit
Cavey, M.; Charroux, B.; Travaillard, S.; Maniere, G.; Berthelot-Grosjean, M.; Quitard, S.; Minervino, C.; Detailleur, B.; Grosjean, Y.; Prud'homme, B.
10.1101/2022.06.22.497171 — evolutionary biology — Posted on 2022-06-26
723 Foxm1 drives cardiomyocyte proliferation in adult zebrafish after cardiac injury
Zuppo, D. A.; Missinato, M. A.; Santana-Santos, L.; Li, G.; Benos, P.; Tsang, M.
10.1101/2022.06.22.497073 — developmental biology — Posted on 2022-06-26
725 Cell-Type-Specific Epigenetic Priming of Gene Expression in Nucleus Accumbens by Cocaine
Mews, P.; Van der Zee, Y.; Kronman, H.; Gurung, A.; Ramakrishnan, A.; Browne, C.; Futamura, R.; Ryan, M.; Reyes, A. A.; Garcia, B.; Sidoli, S.; Shen, L.; Nestler, E. J.
10.1101/2022.06.24.497533 — molecular biology — Posted on 2022-06-26
728 sRNA-controlled iron sparing response in Staphylococci
Coronel-Tellez, R. H.; Pospiech, M.; Barrault, M.; Liu, W.; Bordeau, V.; Vasnier, C.; Felden, B.; Sargueil, B.; Bouloc, P.
10.1101/2022.06.26.497478 — microbiology — Posted on 2022-06-26
729 Cross-Protective Antibodies Against Common Endemic Respiratory Viruses
Caban, M.; Rodarte, J.; Bibby, M.; Gray, M. D.; Taylor, J. J.; Pancera, M.; Boonyaratanakornkit, J.
10.1101/2022.06.26.497647 — microbiology — Posted on 2022-06-26
730 Ticagrelor combined with aspirin displays the signature of regulating the gut microbiome in consistence with improving the immuno-inflammatory response in atherosclerosis
Bai, Z.; Zhang, Q.; Liu, Y.; Zhao, Y.; Yan, R.; Yang, L.; Ma, H.; Ren, Y.; Wang, T.; Li, Y.; Liu, Y.; Jiang, X.; Wang, R.; Jia, S.; Zhang, X.; Wang, H.
10.1101/2022.06.22.497138 — immunology — Posted on 2022-06-26
733 Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses
Hodge, S.; Krauss, M.; Kaymak, I.; King, J.; Howden, A.; Panic, G.; Grencis, R.; Swann, J.; Sinclair, L.; Hepworth, M.
10.1101/2022.06.22.497162 — immunology — Posted on 2022-06-26
734 Reuniens transiently synchronizes memory networks at beta frequencies
Jayachandran, M.; Viena, T. D.; Garcia, A.; Veliz, A. V.; Layva, S.; Roldan, V.; Vertes, R. P.; Allen, T. A.
10.1101/2022.06.21.497087 — neuroscience — Posted on 2022-06-26
737 Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex
Muhleip, A.; Flygaard, R. K.; Haapanen, O.; Baradaran, R.; Gruhl, T.; Tobiasson, V.; Marechal, A.; Sharma, V.; Amunts, A.
10.1101/2022.06.26.497646 — biochemistry — Posted on 2022-06-26
738 PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period
Philpott, J. M.; Freeberg, A. M.; Park, J.; Lee, K.; Ricci, C. G.; Hunt, S. R.; Narasimamurthy, R.; Segal, D. H.; Robles, R.; Cao, Y. D.; Tripathi, S.; McCammon, J. A.; Virshup, D. M.; Chiu, J. C.; Lee, C.; Partch, C. L.
10.1101/2022.06.24.497549 — biochemistry — Posted on 2022-06-26
739 Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism
Luo, S.; Zhang, J.; Kreutzberger, A. J. B.; Eaton, A.; Edwards, R. J.; Jing, C.; Dai, H.-Q.; Sempowski, G. D.; Cronin, K.; Parks, R.; Ye, A. Y.; Mansouri, K.; Barr, M.; Pishesha, N.; Williams, A. C.; Francisco, L. V.; Saminathan, A.; Peng, H.; Batra, H.; Bellusci, L.; Khurana, S.; Alam, S. M.; Montefiori, D. C.; Saunders, K. O.; Tian, M.; Ploegh, H.; Kirchhausen, T.; Chen, B.; Haynes, B. F.; Alt, F. W.
10.1101/2022.06.26.497634 — immunology — Posted on 2022-06-26
740 Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle
Capovilla, G.; Braakman, R.; Fournier, G.; Hackl, T.; Schwartzman, J. A.; Lu, X.; Yelton, A.; Longnecker, K.; Soule, M. K.; Thomas, E.; Swarr, G.; Mongera, A.; Payette, J.; Waldbauer, J.; Kujawinski, E. B.; Cordero, O. X.; Chisholm, S. W.
10.1101/2022.06.23.497379 — ecology — Posted on 2022-06-26
741 OligoFlow: rapid and sensitive virus quantification using flow cytometry and oligonucleotide hybridization
Paterson, J. S.; Dann, L. M.; Carlson-Jones, J.; Giles, S. K.; McIvor, C.; Speck, P. G.; Mitchell, J. G.
10.1101/2022.06.23.497420 — microbiology — Posted on 2022-06-26
745 A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury and matrix remodeling in patients with stone disease
Canela, V. H.; Bowen, W. S.; Ferreira, R. M.; Lingeman, J. E.; Sabo, A. R.; Barwinska, D.; Winfree, S.; Lake, B.; Cheng, Y.-H.; LaFavers, K.; Zhang, K.; Coe, F. L.; Worcester, E.; Jain, S.; Eadon, M. T.; Williams, J. C.; El-Achkar, T. M.; Kidney Precision Medicine Project,
10.1101/2022.06.22.497218 — genomics — Posted on 2022-06-26
746 The ontogeny of asymmetry in echolocating whales
Lanzetti, A.; Coombs, E. J.; Portela-Miguez, R.; Fernandez, V.; Goswami, A.
10.1101/2022.06.24.497462 — evolutionary biology — Posted on 2022-06-26
747 The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years
De Carvalho, M.; Jia, G.-S.; Nidamangala Srinivasa, A.; Billmyre, R. B.; Xu, Y.-H.; Lange, J. J.; Sabbarini, I. M.; Du, L.-L.; Zanders, S. E.
10.1101/2022.06.24.497463 — evolutionary biology — Posted on 2022-06-26
748 Emergent ecosystem functions follow simple quantitative rules
Diaz-Colunga, J.; Skwara, A.; Vila, J. C. C.; Bajic, D.; Sanchez, A.
10.1101/2022.06.21.496987 — ecology — Posted on 2022-06-26
752 Increased birth rank of homosexual males: disentangling the older brother effect and sexual antagonism hypothesis
Raymond, M.; Turek, D.; Durand, V.; Nila, S.; Suryobroto, B.; Vadez, J.; Barthes, J.; Apostolou, M.; Crochet, P.-A.
10.1101/2022.02.22.481477 — evolutionary biology — Posted on 2022-06-26
759 Packing limits and developmental integration are not sufficient to explain stomatal anatomical evolution in flowering plants
Muir, C. D.; Conesa, M. A.; Galmes, J.; Pathare, V. S.; Rivera, P.; Rodriguez, R. L.; Terrazas, T.; Xiong, D.
10.1101/2021.09.02.457988 — plant biology — Posted on 2022-06-26
761 Dead infant carrying by chimpanzee mothers in the Budongo Forest
Soldati, A.; Fedurek, P.; Crockford, C.; Adue, S.; Akankwasa, J. W.; Asiimwe, C.; Asua, J.; Atayo, G.; Chandia, B.; Freymann, E.; Fryns, C.; Muhumuza, G.; Taylor, D.; Zuberbuhler, K.; Hobaiter, C.
10.1101/2021.12.22.473786 — animal behavior and cognition — Posted on 2022-06-26
763 AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro
Sieckmann, K.; Winnerling, N.; Huebecker, M.; Leyendecker, P.; Ribeiro, D.; Gnad, T.; Pfeifer, A.; Wachten, D.; Hansen, J. N.
10.1101/2022.06.04.494793 — cell biology — Posted on 2022-06-26
765 Aging-related iron deposit prevents the benefits of HRT from late postmenopausal atherosclerosis
Xu, T.; Cai, J.; Wang, L.; Xu, L.; Zhao, H.; Wang, F.; Meyron-Holtz, E. G.; Missirlis, F.; Qiao, T.; Li, K.
10.1101/2022.06.24.497502 — cell biology — Posted on 2022-06-26
767 Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
Magen, A.; Hamon, P.; Fiaschi, N.; Troncoso, L.; Humblin, E.; D'souza, D.; Dawson, T.; Park, M. D.; Kim, J.; Hamel, S.; Buckup, M.; Chang, C.; Tabachnikova, A.; Schwartz, H.; Malissen, N.; Lavin, Y.; Soares-Schanoski, A.; Giotti, B.; Hegde, S.; Mattiuz, R.; Hennequin, C.; Le Berichel, J.; Zhao, Z.; Ward, S.; Fiel, I.; Price, C.; Fernandez, N.; He, J.; Kou, B.; Dobosz, M.; Li, L.; Adler, C.; Ni, M.; Wei, Y.; Wang, W.; Gupta, N. T.; Kundu, K.; Cygan, K.; Deering, R. P.; Tsankov, A.; Kim-Schulze, S.; Gnjatic, S.; Kenigsberg, E.; Schwartz, M.; Marron, T. U.; Thurston, G.; Kamphorst, A. O.; Merad,
10.1101/2022.06.22.497216 — immunology — Posted on 2022-06-26
771 Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy
Sarkar, O. S.; Donninger, H.; Al Rayyan, N.; Chew, L. C.; Stamp, B.; Zhang, X.; Whitt, A.; Li, C.; Hall, M.; Mitchell, R. A.; Zippelius, A.; Eaton, J.; Chesney, J. A.; Yaddanapudi, K.
10.1101/2022.06.22.497260 — cell biology — Posted on 2022-06-25
772 DNA packaging via hierarchical chromatin structures revealed by live-cell 3D imaging
ZHENG, Y.; Ye, S.; Li, S.; Liu, C.; Luo, S.; Chen, Y.; Li, Y.; Huang, L.; Deng, S.; Chen, P.; Zhang, Y.; Ji, W.; Luo, R.; Li, G.; Yang, D.
10.1101/2022.06.22.497271 — cell biology — Posted on 2022-06-25
773 Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis
Dressel, N.; Natusch, L.; Munz, C.; Costas-Ramon, S.; Morcos, M. N. F.; Loff, A.; Hiller, B.; Luksch, H.; Roesen-Wolff, A.; Roers, A.; Behrendt, R.; Gerbaulet, A.
10.1101/2022.06.24.497496 — cell biology — Posted on 2022-06-25
775 Automatic sub-precision membrane contact site detection identifies convoluted tubular riboMERCs
Cardoen, B.; GAO, G.; Vandevoorde, K. R.; Alan, P.; Liu, W.; Vogl, A. W.; Hamarneh, G.; Nabi, I. R.
10.1101/2022.06.23.497346 — cell biology — Posted on 2022-06-26
776 Regulation of urea cycle by reversible high stoichiometry lysine succinylation
Zhang, R.; Xie, X.; Carrico, C.; Meyer, J. G.; Wei, L.; Bons, J.; Rose, J.; Riley, R.; Kwok, R.; Kumaar, P. A.; He, W.; Nishida, Y.; Liu, X.; Locasale, J.; Schilling, B.; Verdin, E.
10.1101/2022.06.24.497535 — molecular biology — Posted on 2022-06-26
777 Early exposure to high-fat diet impairs central and peripheral metabolic function: Impacts on cognition and mitochondrial function
Vilela, W. R.; Bellozi, P. M. Q.; Picolo, V. L.; Cavadas, B. N.; Marques, K. V. S.; Pereira, L. T. G.; Amato, A. A.; Magalhaes, K. G.; Mortari, M. R.; Goulart, J. T.; de Bem, A. F.
10.1101/2022.06.22.496258 — neuroscience — Posted on 2022-06-26
778 Membrane curvature governs the distribution of Piezo1 in cellulo
Yang, S.; Arnold, S.; Li, B.; Wang, H.; Wang, M.; Cox, C. D.; Shi, Z.
10.1101/2022.06.22.497259 — biophysics — Posted on 2022-06-25
782 Insulin receptor turnover in fasting is dependent on NAGLU-mediated beta-dystroglycan deglycosylation
Joseph, S.; Zbidat, S.; Volodin, A.; Kasiviswanathan, D.; Fried, A. I.; Armani, A.; Gilda, J. E.; Cohen, S.
10.1101/2022.06.24.497215 — cell biology — Posted on 2022-06-25
784 Defining the Ligand-dependent Interactome of the Sigma 1 Receptor
Zhao, J.; Veeranan-Karmegam, R.; Baker, F.; Mysona, B.; Bagchi, P.; Liu, Y.; Smith, S.; Gonsalvez, G. B.; Bollinger, K.
10.1101/2022.06.22.497210 — cell biology — Posted on 2022-06-25
785 CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side.
van den Berg, C. M.; Volkov, V. A.; Schnorrenberg, S.; Huang, Z.; Stecker, K. E.; Grigoriev, I.; Patzke, S.; Zimmermann, T.; Dogterom, M.; Akhmanova, A.
10.1101/2022.06.23.497320 — cell biology — Posted on 2022-06-25
786 Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1.
Conte, T.; Bishop, G. D.; Orfi, Z.; Mokhtari, I.; Deprez, A.; Roussel, M.-P.; Cote, I.; Pellerito, O.; Maggiorani, D.; Benabdallah, B.; Leclerc, S.; Feulner, L.; Mathieu, J.; Gagnon, C.; Andelfinger, G.; Beausejour, C.; McGraw, S.; Duchesne, E.; Dumont, N.
10.1101/2022.06.22.497227 — cell biology — Posted on 2022-06-25
789 Neuronal identity defines a-synuclein and tau toxicity
Praschberger, R.; Kuenen, S.; Schoovaerts, N.; Kaempf, N.; Janssens, J.; Swerts, J.; Nachman, E.; Calatayud, C.; Aerts, S.; Poovathingal, S.; Verstreken, P.
10.1101/2022.06.24.496376 — neuroscience — Posted on 2022-06-25
790 Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes
De Sarkar, N.; Patton, R. D.; Doebley, A.-L.; Hanratty, B.; Kreitzman, A. J.; Sarthy, J. F.; Ko, M.; Adil, M.; Brahma, S.; Meers, M. P.; Janssens, D. H.; Ang, L. S.; Coleman, I.; Bose, A.; Dumpit, R. F.; Lucas, J. M.; Nunez, T. A.; Nguyen, H. M.; McClure, H. M.; Pritchard, C. C.; Schweizer, M. T.; Morrissey, C.; Choudhury, A. D.; Baca, S. C.; Berchuck, J. E.; Freedman, M. L.; Ahmad, K.; Haffner, M. C.; Montgomery, B.; Corey, E.; Henikoff, S.; Nelson, P. S.; Ha, G.
10.1101/2022.06.21.496879 — cancer biology — Posted on 2022-06-25
792 Culture-Independent Detection and Identification of Leptospira Serovars
Matthias, M. A.; Lubar, A.; Lanka Acharige, S. S.; Chaiboonma, K. N.; Pilau, N. N.; Marroquin, A. S.; Jayasundara, D.; Agampodi, S. B.; Vinetz, J. M.
10.1101/2022.06.24.497575 — microbiology — Posted on 2022-06-25
795 Gender and comorbidity moderate the relationship between mood disorder symptoms and effortful avoidance performance
Forys, B. J.; Tomm, R. J.; Stamboliyska, D.; Terpstra, A. R.; Clark, L.; Chakrabarty, T.; Floresco, S. B.; Todd, R. M.
10.1101/2022.06.21.497075 — neuroscience — Posted on 2022-06-25
798 Drug-induced adaptation along a resistance continuum in cancer cells
Franca, G. S.; Baron, M.; Pour, M.; King, B. R.; Rao, A.; Misirlioglu, S.; Barkley, D.; Dolgalev, I.; Ho-Tang, K.; Avital, G.; Kuperwaser, F.; Patel, A.; Levine, D. A.; Lionnet, T.; Yanai, I.
10.1101/2022.06.21.496830 — cancer biology — Posted on 2022-06-25
799 Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress
Saab, J. J. A.; Dzierozynski, L. N.; Jonker, P. B.; Zhu, Z.; Chen, R. N.; Oh, M.; Sheehan, C.; Macleod, K. F.; Weber, C. R.; Muir, A.
10.1101/2022.06.21.497008 — cancer biology — Posted on 2022-06-25
800 EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry
Luan, H.; Bielecki, T. A.; Mohapatra, B. C.; Islam, N.; Mushtaq, I.; Bhat, A. M.; Mirza, S.; Chakraborty, S.; Raza, M.; Storck, M. D.; Meza, J. L.; Thoreson, W. B.; Coulter, D. W.; Rakha, E.; Band, V.; Band, H.
10.1101/2022.06.21.497035 — cancer biology — Posted on 2022-06-25
801 Validating the representation of distance between infarctdiseases using Word2Vec word embedding
Yokokawa, D.; Noda, K.; Yanagita, Y.; Uehara, T.; Ohira, Y.; Shikino, K.; Tsukamoto, T.; Ikusaka, M.
10.1101/2022.06.21.496958 — bioinformatics — Posted on 2022-06-25
803 LIRcentral: a manually curated online database of experimentally validated functional LIR-motifs
Chatzichristofi, A.; Sagris, V.; Pallaris, A.; Eftychiou, M.; Kalvari, I.; Price, N.; Theodosiou, T.; Iliopoulos, I.; Nezis, I. P.; Promponas, V. J.
10.1101/2022.06.21.496832 — bioinformatics — Posted on 2022-06-25
805 Abundant Phenotypic Parallelism, Incomplete Lineage Sorting, and Introgression in Open-Habitat Chats
Alaei Kakhki, N.; Schweizer, M.; Lutgen, D.; Bowie, R. C. K.; Shirihai, H.; Suh, A.; Schielzeth, H.; Burri, R.
10.1101/2022.06.21.496980 — evolutionary biology — Posted on 2022-06-25
807 Migratory behavior is positively associated with genetic diversity in butterflies
Garcia-Berro, A.; Talla, V.; Vila, R.; Wai, H. K.; Shipilina, D.; Chan, K.-G.; Pierce, N. E.; Backström, N.; Talavera, G.
10.1101/2022.06.21.496610 — evolutionary biology — Posted on 2022-06-25
810 Spatial distribution and physicochemical properties of respirable volcanic ash from the 16-17 August 2006 Tungurahua eruption (Ecuador), and alveolar epithelium response in-vitro
Eychenne, J.; Gurioli, L.; Damby, D.; Belville, C.; Schiavi, F.; Marceau, G.; Szczepaniak, C.; Blavignac, C.; Laumonier, M.; Le Pennec, J.-L.; Nedelec, J.-M.; BLANCHON, L.; Sapin, V.
10.1101/2022.06.21.496955 — ecology — Posted on 2022-06-25
821 Non-redundant odorant detection in a locust
Chang, H.; Unni, A.; Tom, M. T.; Cortes Llorca, L.; Brase, S.; Bucks, S.; Weniger, K.; Bisch-Knaden, S.; Hansson, B. S.; Knaden, M.
10.1101/2022.06.21.496967 — neuroscience — Posted on 2022-06-25
822 Blocking D2/D3 dopamine receptors increases volatility of beliefs when we learn to trust others
Mikus, N.; Eisenegger, C.; Mathys, C.; Clark, L.; Muller, U.; Robbins, T.; Lamm, C.; Naef, M.
10.1101/2022.06.21.496956 — neuroscience — Posted on 2022-06-25
823 White matter and literacy: a dynamic system in flux
Roy, E.; Richie-Halford, A.; Kruper, J.; Narayan, M.; Bloom, D.; Brown, T. T.; Jernigan, T. L.; McCandliss, B. D.; Rokem, A.; Yeatman, J. D.
10.1101/2022.06.21.497048 — neuroscience — Posted on 2022-06-25
825 Updated Variant Curation Expert Panel Criteria and Pathogenicity Classifications for 251 Variants for RYR1-related Malignant Hyperthermia Susceptibility
Johnston, J. J.; Dirksen, R. T.; Girard, T.; Hopkins, P. M.; Kraeva, N.; Ognoon, M.; Radenbaugh, B.; Riazi, S.; Robinson, R. L.; Sadic, L. A.; Sambuughin, N.; Saxena, R.; Shepherd, S.; Stowell, K.; Weber, J.; Yoo, S.; Rosenberg, H.; Biesecker, L. G.
10.1101/2022.06.23.497341 — genetics — Posted on 2022-06-25
828 Auxin-dependent acceleration of cell division rates regulates root growth at elevated temperature
Quint, M.; Ai, H.; Bellstaedt, J.; Bartusch, K. S.; Eschen-Lippold, L.; Babben, S.; Balcke, G. U.; Tissier, A.; Hause, B.; Andersen, T. G.; Delker, C.
10.1101/2022.06.22.497127 — plant biology — Posted on 2022-06-25
829 Phytochromes mediate germination inhibition under red, far-red, and white light in Aethionema arabicum
Merai, Z.; Xu, F.; Musilek, A.; Ackerl, F.; Khalil, S.; Soto-Jimenez, L. M.; Lalatovic, K.; Klose, C.; Tarkowska, D.; Tureckova, V.; Strnad, M.; Mittelsten Scheid, O.
10.1101/2022.06.24.497527 — plant biology — Posted on 2022-06-25
830 AIM1-dependent high basal SA accumulation modulates stomatal aperture in rice
Xu, L.; Zhao, H.; Wang, J.; Wang, X.; Jia, X.; Xu, Z.; Li, R.; Jiang, K.; Chen, Z.; Luo, J.; Xie, X.; Yi, K.
10.1101/2022.06.23.497111 — plant biology — Posted on 2022-06-25
833 Liquid-like assembly of VASP drives actin polymerization and bundling
Graham, K. D.; Chandrasekaran, A.; Wang, L.; Ladak, A.; Lafer, E. M.; Rangamani, P.; Stachowiak, J. C.
10.1101/2022.05.09.491236 — biophysics — Posted on 2022-06-25
838 GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Cordova, R.; Misra, J.; Amin, P. H.; Klunk, A. J.; Damayanti, N. P.; Carlson, K. R.; Elmendorf, A. J.; Hyeong-Geug, K.; Mirek, E. T.; Miller, M. J.; Dong, X. C.; Cheng, L.; Anthony, T. G.; Pili, R.; Wek, R. C.; Staschke, K. A.
10.1101/2022.06.17.496598 — cancer biology — Posted on 2022-06-25
840 Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Cardenas Canales, E. M.; Stockmaier, S.; Cronin, E.; Rocke, T.; Osorio, J. E.; Carter, G. G.
10.1101/2022.06.06.495012 — animal behavior and cognition — Posted on 2022-06-25
841 Genome-wide association studies across environmental and genetic contexts reveal complex genetic architecture of symbiotic extended phenotypes
Batstone, R. T.; Lindgren, H. K.; Allsup, C. M.; Goralka, L. A.; Riley, A. B.; Grillo, M. A.; Marshall-Colon, A.; Heath, K.
10.1101/2021.08.03.454976 — evolutionary biology — Posted on 2022-06-25
843 Retinoic acid control of pax8 during renal specification of Xenopus pronephros involves hox and meis3
Durant-Vesga, J.; Suzuki, N.; Ochi, H.; Le Bouffant, R.; Eschstruth, A.; Ogino, H.; Umbhauer, M.; Riou, J.-F.
10.1101/2022.06.21.496994 — developmental biology — Posted on 2022-06-25
844 Delineation and birth of a multi-layer intestinal stem cell niche
McCarthy, N.; Tie, G.; Madha, S.; Kraiczy, J.; Maglieri, A.; Shivdasani, R.
10.1101/2021.09.28.462142 — developmental biology — Posted on 2022-06-25
846 Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.
Siepe, D. H.; Henneberg, L. T.; Wilson, S. C.; Hess, G. T.; Bassik, M. C.; Zinn, K.; Garcia, K. C.
10.1101/2022.06.22.497261 — cell biology — Posted on 2022-06-25
847 Interferon regulates stem cell function at all ages by orchestrating mTOR and cell cycle
Carvajal Ibanez, D.; Skabkin, M.; Hooli, J.; Cerrizuela, S.; Goepferich, M.; Jolly, A.; Zumwinkel, M.; Bertolini, M.; Hoefer, T.; Kramer, G.; Anders, S.; Teleman, A. A.; Marciniak-Czochra, A.; Martin-Villalba, A.
10.1101/2022.02.03.478954 — neuroscience — Posted on 2022-06-25
850 Multiple resistance of Colletotrichum truncatum from soybean to QoI and MBC fungicides in Brazil
Rogerio, F.; Linhares de Castro, R. R.; Massola Junior, N. S.; Boufleur, T. R.; dos Santos, R. F.
10.1101/2022.06.24.497464 — microbiology — Posted on 2022-06-24
851 Enhancing NeuroD1 Expression to Convert Lineage-Traced Astrocytes into Neurons
Xu, L.; Xiang, Z.-Q.; Guo, Y.-W.; Xu, Y.-G.; Liu, M.-H.; Ji, W.-Y.; He, S.; Lei, W.-L.; Li, W.; Wu, Z.; Chen, G.
10.1101/2022.06.21.496971 — neuroscience — Posted on 2022-06-24
853 Arginase 1 is a key driver of immune suppression in pancreatic cancer
Menjivar, R. E.; Nwosu, Z. C.; Du, W.; Donahue, K.; Espinoza, C.; Brown, K.; Velez, A.; Yan, W.; Lima, F.; Bischoff, A.; Kadiyala, P.; Salas-Escabillas, D.; Halbrook, C. J.; Bednar, F.; Carpenter, E.; Crawford, H.; Zhang, Y.; Lyssiotis, C. A.; di Magliano, M.
10.1101/2022.06.21.497084 — cancer biology — Posted on 2022-06-24
856 A Photonic Biosensor-Integrated Tissue Chip Platform for Real-Time Sensing of Lung Epithelial Inflammatory Markers
Cognetti, J. S.; Moen, M. T.; Brewer, M. G.; Bryan, M. R.; Tice, J. D.; Mcgrath, J. L.; Miller, B. R.
10.1101/2022.06.21.497028 — bioengineering — Posted on 2022-06-24
859 Reprogramming brain immunosurveillance with engineered cytokines
Tabet, A.; Agarwal, Y.; Stinson, J.; Apra, C.; Will, V.; Manthey, M.; Momin, N.; Sheen, A.; Murdock, M.; Santollani, L.; Tsai, L.-H.; Chiu, I.; Lawler, S. E.; Irvine, D. J.; Wittrup, K. D.; Anikeeva, P.
10.1101/2022.06.21.497082 — bioengineering — Posted on 2022-06-24
860 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex
Kisonaite, M.; Wild, K.; Lapouge, K.; Valentin Gese, G.; Kellner, N.; Hurt, E.; Dr. Sinning, I.
10.1101/2022.06.24.497458 — biochemistry — Posted on 2022-06-24
861 The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2
Jiang, H.; Ariyoshi, M.; Watanabe, R.; Makino, F.; Namba, K.; Fukagawa, T.
10.1101/2022.06.24.497480 — biochemistry — Posted on 2022-06-24
862 Half-calcified Calmodulin Promotes Basal Activity and Inactivation of the Calcium Channel CaV1.2.
Bartels, P.; Salveson, I. C.; Coleman, A. M.; Anderson, D.; Jeng, G.; Estrada-Tobar, Z. M.; Man, K. N. M.; Yu, Q.; Kuzmenkina, E.; Nieves-Cintron, M.; Navedo, M. F.; Horne, M. C.; Hell, J. W.; Ames, J. B.
10.1101/2022.06.24.497440 — biochemistry — Posted on 2022-06-24
865 NHR-23 and SPE-44 regulate distinct sets of genes during C. elegans spermatogenesis
Ragle, J. M.; Morrison, K. N.; Vo, A. A.; Johnson, Z. E.; Hernandez Lopez, J.; Rechtsteiner, A.; Shakes, D. C.; Ward, J. D.
10.1101/2022.06.24.497528 — genetics — Posted on 2022-06-24
866 Dynamic interplay of protrusive microtubule and contractile actomyosin forces drives tissue extension
Singh, A.; Thale, S.; Leibner, T.; Ricker, A.; Nusse, H.; Klingauf, J.; Ohlberger, M.; Matis, M.
10.1101/2022.06.21.496930 — developmental biology — Posted on 2022-06-24
870 Predicting metabolomic profiles from microbial composition through neural ordinary differential equations
Wang, T.; Wang, X.-W.; Lee-Sarwar, K.; Litonjua, A. A.; Weiss, S. T.; Sun, Y.; Maslov, S.; Liu, Y.-Y.
10.1101/2022.06.23.497381 — microbiology — Posted on 2022-06-24
872 Unique Pakistani gut microbiota highlights population-specific microbiota signatures of type 2 diabetes mellitus
Saleem, A.; Ikram, A.; Dikareva, E.; Lahtinen, E.; Matharu, D.; Pajari, A.-M.; de Vos, W. M.; Hasan, F.; Salonen, A.; Jian, C.
10.1101/2022.06.23.497392 — microbiology — Posted on 2022-06-24
873 Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system
Jean-Pierre, F.; Hampton, T. H.; Schultz, D.; Hogan, D.; Groleau, M.-C.; Deziel, E.; O'Toole, G.
10.1101/2022.06.23.497319 — microbiology — Posted on 2022-06-24
874 A novel time-lapse imaging method for studying developing bacterial biofilms
Futo, M.; Siroki, T.; Koska, S.; Corak, N.; Tusar, A.; Domazet-Loso, M.; Domazet-Loso, T.
10.1101/2022.06.24.497465 — microbiology — Posted on 2022-06-24
877 Mapping molecular determinants of Cav2.2 inhibition by RGK proteins and homologs in Xenopus oocytes
Sasson, Y.; Subramaniam, S.; Buki, T.; Almagor, L.; Chomsky-Hecht, O.; Katz, M.; Puhl, H.; Ikeda, S. R.; Dascal, N.; Hirsch, J.
10.1101/2022.06.21.496996 — physiology — Posted on 2022-06-24
881 DNA Release from Complex Plant Tissue Using Focused Ultrasound Extraction (FUSE)
Stettinius, A.; Holmes, H.; Zhang, Q.; Mehochko, I.; Winters, M.; Hutchison, R.; Maxwell, A.; Holliday, J.; Vlaisavljevich, E.
10.1101/2022.06.23.497388 — genetics — Posted on 2022-06-24
882 Diversity and biogeography of plant leaf bacteria along a latitudinal gradient
Wang, Z.; Jiang, Y.; Zhang, M.; Chu, C.; Chen, Y.; Fang, S.; Jin, G.; Jiang, M.; Lian, J.; Li, Y.; Liu, Y.; Ma, K.; Mi, X.; Qiao, X.; Wang, X.; Wang, X.; Xu, H.; Ye, W.; Zhu, L.; Zhu, Y.; He, F.; Kembel, S. W.
10.1101/2022.06.23.497395 — ecology — Posted on 2022-06-24
886 Mapping Responsive Genomic Elements to Heat Stress in a Maize Diversity Panel
Liang, Z.; Myers, Z. A.; Petrella, D.; Engelhorn, J.; Hartwig, T.; Springer, N. M.
10.1101/2022.06.23.497238 — plant biology — Posted on 2022-06-24
889 Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast
Chen, X.; Selvaraj, P.; Lin, L.; Fang, W.; Wu, C.; Yang, P.; Zhang, J.; Abubakar, Y. S.; Yang, F.; Lu, G.; Liu, W.; Wang, Z.; Naqvi, N. I.; Zheng, W.
10.1101/2022.06.22.497169 — plant biology — Posted on 2022-06-24
890 Cell wall extensin arabinosylation is required for root directional response to salinity
Zou, Y.; Gigli-Bisceglia, N.; van Zelm, E.; Julkowska, M. M.; Zeng, Y.; Cheng, Y.; Koevoets, I. T.; Jorgensen, B.; Giesbers, M.; Vroom, J.; Ketelaar, T.; Petersen, B.; Zhang, Y.; Testerink, C.
10.1101/2022.06.22.497042 — plant biology — Posted on 2022-06-24
895 A cell-based, spike protein binding assay highlights differences in antibody neutralising capacity for SARS-CoV-2 variants
Harrison, N.; Richardson, L.; Pallini, C.; Morano, I.; Jinks, E.; Cowley, J.; Chan, H.; Hill, H.; Matas de las Heras, C.; Teodosio, A.; Lavado, A. S.; Dafforn, T. R.; Grammatopoulos, D. K.; Gordon, J.; Brady, C. A.; Young, L. S.; Barnes, N. M.; Stamataki, Z.; Qureshi, O. S.
10.1101/2022.06.24.496409 — cell biology — Posted on 2022-06-24
896 The metabolic influence of the core ciliate Entodinium caudatum within the rumen microbiome
Andersen, T. O.; Altshuler, I.; de Leon, A. V. P.; Walter, J.; McGovern, E.; Keogh, K.; Martin, C.; Bernard, L.; Fougere, H.; Morgavi, D. P.; Park, T.; Firkins, J. L.; Yu, Z.; Hvidsten, T. R.; Waters, S. M.; Popova, M.; Arntzen, M.; Hagen, L. H.; Pope, P. B.
10.1101/2022.06.22.497163 — microbiology — Posted on 2022-06-24
897 In Vitro Evaluation and Mitigation of Niclosamide Liabilities as a COVID-19 Treatment.
Wotring, J. W.; McCarty, S. M.; Shafiq, K.; Zhang, C. J.; Nguyen, T.; Meyer, S. R.; Fursmidt, R.; Mirabelli, C.; Clasby, M. C.; Wobus, C. E.; O'Meara, M. J.; Sexton, J. Z.
10.1101/2022.06.24.497526 — microbiology — Posted on 2022-06-24
899 Investigating the mutations in the SARS-CoV-2 proteins among European countries
Abavisani, M.; Rahimian, K.; Khayami, R.; Kodori, M.; Sisakht, M. M.; Mahmanzar, M.; Meshkat, Z.
10.1101/2022.06.23.497239 — microbiology — Posted on 2022-06-24
900 The Functional Landscape of SARS-CoV-2 3CL Protease
Iketani, S.; Hong, S. J.; Sheng, J.; Bahari, F.; Culbertson, B.; Atanaki, F. F.; Aditham, A. K.; Kratz, A. F.; Luck, M. I.; Tian, R.; Goff, S. P.; Montazeri, H.; Sabo, Y.; Ho, D. D.; Chavez, A.
10.1101/2022.06.23.497404 — microbiology — Posted on 2022-06-24
901 Monitoring SARS-CoV-2 infection using a double reporter-expressing virus
Chiem, K.; Park, J.-G.; Morales Vasquez, D.; Plemper, R. K.; Torrelles, J. B.; Kobie, J.; Walter, M. R.; Ye, C.; Martinez-Sobrido, L.
10.1101/2022.06.23.497376 — microbiology — Posted on 2022-06-24
902 Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
Thorpe, H. A.; Tourrette, E.; Yahara, K.; Vale, F. F.; Liu, S.; Oleastro, M.; Alarcon, T.; Perets, T.; Latifi-Navid, S.; Yamaoka, Y.; Martinez-Gonzalez, B.; Karayiannis, I.; Karamitros, T.; Sgouras, D.; Elamin, W.; Pascoe, B.; Sheppard, S.; Ronkainen, J.; Aro, P.; Engstrand, L.; Agreus, L.; Suerbaum, S.; Thorell, K.; Falush, D.
10.1101/2021.06.05.447065 — evolutionary biology — Posted on 2022-06-24
910 Foldseek: fast and accurate protein structure search
van Kempen, M.; Kim, S.; Tumescheit, C.; Mirdita, M.; Gilchrist, C. L. M.; Soeding, J.; Steinegger, M.
10.1101/2022.02.07.479398 — bioinformatics — Posted on 2022-06-24
911 Adjustment of spurious correlations in co-expression measurements from RNA-Sequencing data
Hsieh, P.-H.; Lopes-Ramos, C. M.; Zucknick, M.; Sandve, G. K.; Glass, K.; Kuijjer, M. L.
10.1101/2021.03.25.436972 — bioinformatics — Posted on 2022-06-24
918 Longitudinal Changes in Auditory and Reward Systems Following Receptive Music-Based Intervention in Older Adults
Quinci, M.; Belden, A.; Goutama, V.; Gong, D.; Hanser, S.; Donovan, N. J.; Geddes, M.; Loui, P.
10.1101/2021.07.02.450867 — neuroscience — Posted on 2022-06-24
919 Genomic characterization of a wild-like tomato accession from Arizona
Barnett, J. R.; Buonauro, G.; Kuipers, A.; Sapkota, M.; van der Knaap, E.; Razifard, H.
10.1101/2022.02.11.480156 — plant biology — Posted on 2022-06-24
923 Diffusion on PCA-UMAP manifold captures a well-balance of local, global, and continuum structures to denoise single-cell RNA sequencing data
Padron-Manrique, C.; Vazquez Jimenez, A.; Esquivel-Hernandez, D. A.; Martinez-Lopez, Y. E.; Neri-Rosario, D.; Sanchez-Castaneda, J. P.; Giron-Villalobos, D.; Resendis-Antonio, O.
10.1101/2022.06.09.495525 — bioinformatics — Posted on 2022-06-24
926 A CRISPR-engineered Isogenic Model Reveals Altered Neuronal Phenotypes of the 22q11.2 A-B Syndromic Deletion
Paranjape, N.; Lin, Y.-H. T.; Flores-Ramirez, Q.; Sarin, V.; Johnson, A. B.; Chu, J.; Paredes, M.; Wiita, A. P.
10.1101/2022.06.22.497212 — genetics — Posted on 2022-06-24
928 Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors
Antony, C.; George, S. S.; Blum, J.; Somers, P.; Thorsheim, C. L.; Wu-Corts, D. J.; Ai, Y.; Gao, L.; Lv, K.; Tremblay, M. G.; Moss, T.; Tan, K.; Wilusz, J. E.; Ganley, A. R. D.; Pimkin, M.; Paralkar, V. R.
10.1101/2022.01.21.476118 — molecular biology — Posted on 2022-06-24
931 Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma
Shin, J.; Parker, M.; Zhu, I.; Alanizi, A.; Rodriguez, C.; Liu, R.; Watchmaker, P.; Kalita, M.; Blecha, J.; Luu, J.; Wright, B.; Lapi, S.; Flavell, R.; Okada, H.; Tlsty, T.; Wilson, D.; Roybal, K.
10.1101/2022.02.16.480729 — synthetic biology — Posted on 2022-06-24
934 Molecular atlas reveals the tri-sectional spinning mechanism of spider dragline silk
Hu, W.; Jia, A.; Ma, S.; Zhang, G.; Wei, Z.; Lu, F.; Luo, Y.; Zhang, Z.; Sun, J.; Yang, T.; Xia, T.; Li, Q.; Yao, T.; Zheng, J.; Jiang, Z.; Xia, Q.; Wang, Y.
10.1101/2022.06.21.496984 — genomics — Posted on 2022-06-24
936 High-resolution cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function
Jung, M.; Dourado, M.; Maksymetz, J.; Jacobson, A.; Baca, M.; Foreman, O.; Hackos, D. H.; Riol-Blanco, L.; Kaminker, J. S.
10.1101/2022.06.21.497049 — neuroscience — Posted on 2022-06-24
937 Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer
Jones, I.; Dent, L. G.; Higo, T.; Roumeliotis, T. I.; Arias-Garcia, M.; Shree, H.; Pedersen, M.; Chaudhary, J. S.; Bakal, C.
10.1101/2022.06.21.496989 — systems biology — Posted on 2022-06-24
939 Mutability Patterns Across the Spike Glycoprotein Reveal the Diverging and Lineage-specific Evolutionary Space of SARS-CoV-2.
Rojas Chavez, R. A.; Fili, M.; Han, C.; Rahman, S. A.; Bicar, I. G. L.; Gregory, S.; Hu, G.; Das, J.; Brown, G. D.; Haim, H.
10.1101/2022.02.01.478697 — bioinformatics — Posted on 2022-06-24
940 New Hydra Genomes Reveal Conserved Principles of Hydrozoan Transcriptional Regulation
Cazet, J.; Siebert, S.; Morris Little, H.; Bertemes, P.; Primack, A. S.; Ladurner, P.; Achrainer, M.; Fredriksen, M. T.; Moreland, R. T.; Singh, S.; Zhang, S.; Wolfsberg, T. G.; Schnitzler, C. E.; Baxevanis, A. D.; Simakov, O.; Hobmayer, B.; Juliano, C.
10.1101/2022.06.21.496857 — developmental biology — Posted on 2022-06-24
941 Discovery and Genomic Characterization of a Novel Henipavirus, Angavokely virus, from fruit bats in Madagascar
Madera, S.; Kistler, A.; Ranaivoson, H. C.; Ahyong, V.; Andrianiaina, A.; Andry, S.; Raharinosy, V.; Randriambolamanantsoa, T. H.; Ravelomanantsoa, N. A. F.; Tato, C. M.; DeRisi, J. L.; Aguilar, H. C.; Lacoste, V.; Dussart, P.; Heraud, J.-M.; Brook, C. E. L.
10.1101/2022.06.12.495793 — evolutionary biology — Posted on 2022-06-24
942 Increased levels of circulating neurotoxic metabolites in patients with mild Covid19
Santiago-Mujika, E.; Heinrich, K.; George, S.; Capan, C. D.; Forton, C.; Madaj, Z.; Burmeister, A. R.; Sims, M.; Pospisilik, A.; Brundin, P.; Graham, S. F.; Brundin, L.
10.1101/2022.06.22.497189 — neuroscience — Posted on 2022-06-24
943 MuDoGeR: Multi-Domain Genome Recovery from metagenomes made easy
Nunes da Rocha, U.; Kasmanas, J.; Kallies, R.; Saraiva, J. P.; Brizola Toscan, R.; Stefanic, P.; Bicalho, M. F.; Correa, F. B.; Basturk, M. N.; Fousekis, E.; Barbosa, L. M. V.; Plewka, J.; Probst, A. J.; Baldrian, P.; Stadler, P. F.; CLUE-TERRA consortium,
10.1101/2022.06.21.496983 — bioinformatics — Posted on 2022-06-24
945 Exploring the interspecific interactions and the metabolome of the soil isolate Hylemonella gracilis
Tyc, O.; Kulkarni, P.; Ossowicki, A.; Tracanna, V.; Medema, M.; Baarlen, P. v.; van IJcken, W.; Verhoeven, K. J. F.; Garbeva, P.
10.1101/2021.02.11.430889 — microbiology — Posted on 2022-06-24
946 Hemocyte Differentiation to the Megacyte Lineage Enhances Mosquito Immunity Against Plasmodium
Ferreira Barletta, A. B.; Saha, B.; Trisnadi, N.; Talyuli, O.; Raddi, G.; Barillas Mury, C.
10.1101/2021.12.24.474101 — microbiology — Posted on 2022-06-24
949 Characterization of cell-to-cell variation in nuclear transport rates and identification of its sources
Durrieu, L.; Bush, A.; Grande, A.; Johansson, R.; Janzen, D. L. I.; Gollvik, M.; Katz, A.; Cedersund, G.; Colman-Lerner, A.
10.1101/001768 — systems biology — Posted on 2022-06-24
951 Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility
Spreacker, P. J.; Thomas, N. E.; Beeninga, W. F.; Brousseau, M.; Porter, C. J.; Hibbs, K. M.; Henzler-Wildman, K. A.
10.1101/2021.12.04.471113 — biochemistry — Posted on 2022-06-24
952 Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression
Blayney, J. W.; Francis, H.; Camellato, B. R.; Mitchell, L.; Stolper, R.; Boeke, J.; Higgs, D. R.; Kassouf, M.
10.1101/2022.06.20.496856 — genetics — Posted on 2022-06-24
956 Changes in cellular ferritin distribution of human brain tissue during autolysis revealed using analytical electron microscopy
Sunkara, S.; Radulovic, S.; Lipovsek, S.; Birkl, C.; Eggenreich, S.; Birkl-Toeglhofer, A. M.; Schinagl, M.; Funk, D.; Stoeger-Pollach, M.; Haybaeck, J.; Goessler, W.; Ropele, S.; Leitinger, G.
10.1101/2022.01.26.477869 — neuroscience — Posted on 2022-06-24
957 Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
Iglesias, F.; Weston, S.; Avila, S. V.; Zhou, H.; Yousef, S.; Fluchel, M.; Morales, E.; Olson, M. L.; Radhakrishnan, S. V.; Luetkens, T.
10.1101/2022.06.21.496901 — bioengineering — Posted on 2022-06-24
958 Design, development, and preliminary assessment of a novel peripheral intravenous catheter aimed at reducing early failure rates
Doyle, B.; Kelsey, L.; Shelverton, C.; Abbate, G.; Ainola, C.; Carr, P.; Livingstone, S.; Bouquet, M.; Passmore, M.; Wilson, E.; Colombo, S. M.; Sato, K.; Liu, K.; Heinsar, S.; Sato, N.; Wildi, K.; Suen, J.; Fraser, J.; Li Bassi, G.; Keogh, S.
10.1101/2022.06.20.496233 — bioengineering — Posted on 2022-06-24
959 Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobodies
Al-Amin, R. A.; Muthelo, P. M.; Abdurakhmanov, E.; Vincke, C.; Amin, S. P.; Muyldermans, S.; Danielson, U. H.; Landegren, U.
10.1101/2022.01.10.475658 — bioengineering — Posted on 2022-06-24
961 Contrasting patterns of microbial dominance in the Arabidopsis thaliana phyllosphere
Lundberg, D. S.; de Pedro Jove, R.; Na Ayutthaya, P. P.; Karasov, T. L.; Shalev, O.; Poersch, K.; Ding, W.; Bollmann-Giolai, A.; Bezrukov, I.; Weigel, D.
10.1101/2021.04.06.438366 — ecology — Posted on 2022-06-24
962 Dopamine pathway characterization during the reproductive mode switch in the pea aphid
LE TRIONNAIRE, G.; HUDAVERDIAN, S.; RICHARD, G.; TANGUY, S.; GLEONNEC, F.; PRUNIER-LETERME, N.; GAUTHIER, J.-P.; TAGU, D.
10.1101/2020.03.10.984989 — developmental biology — Posted on 2022-06-24
963 Spatio-temporal Control of ERK Pulse Frequency Coordinates Fate Decisions during Mammary Acinar Morphogenesis
Ender, P.; Gagliardi, P. A.; Dobrzynski, M.; Frismantiene, A.; Dessauges, C.; Höhener, T.; Jacques, M.-A.; Cohen, A. R.; Pertz, O.
10.1101/2020.11.20.387167 — cell biology — Posted on 2022-06-24
968 Feedforward ribosome control mitigates gene activation burden
Barajas, C.; Huang, H.-H.; Gibson, J.; Sandoval, L.; Del Vecchio, D.
10.1101/2021.02.11.430724 — synthetic biology — Posted on 2022-06-24
970 Experimental Design and Power Calculation in Omics Circadian Rhythmicity Detection
Zong, W.; Seney, M. L.; Ketchesin, K. D.; Gorczyca, M. T.; Liu, A. C.; Esser, K. A.; Tseng, G.; McClung, C. A.; Huo, Z.
10.1101/2022.01.19.476930 — genomics — Posted on 2022-06-23
971 De Novo, Post-Zygotic, Inter-Tissue Mosaicism of Cell Autonomous ADNP Mutations in Autistic Individuals: Restricted Environmental Contribution
Mohiuddin, M.; Marusic, Z.; Anicic, M.; Anke, V. D.; Cappuyns, E.; Ludovico, R.; Vitriolo, A.; Kleiman, G. H.; Grigg, I.; Testa, G.; Gozes, I.; Kooy, R. F.; Pearson, C. E.
10.1101/2022.06.21.496616 — genetics — Posted on 2022-06-24
972 Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant
Min, K. W.; Kim, N.; Lee, J. H.; Sung, Y.; Kim, M.; Lee, E. J.; Kim, J.-H.; Lee, J.; Kim, J.-M.; Cho, W.; Yang, J. M.; Kim, N.; Kim, J.; Lee, C. J. J.; Park, Y.-G.; Lee, S.-H.; Lee, H.-W.; Kim, J. W.
10.1101/2020.10.20.346551 — developmental biology — Posted on 2022-06-23
975 Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis
Iwase, A.; Uchijima, Y.; Seya, D.; Kida, M.; Higashiyama, H.; Matsui, K.; Taguchi, A.; Yamamoto, S.; Fukuda, S.; Nomura, S.; Kohro, T.; Shukunami, C.; Akiyama, H.; Seki, M.; Suzuki, Y.; Wada, Y.; Aburatani, H.; Kurihara, Y.; Miyagawa-Tomita, S.; Kurihara, H.
10.1101/2022.06.23.497419 — developmental biology — Posted on 2022-06-24
977 The metabolic influence of the core ciliate Entodinium caudatum within the rumen microbiome
Andersen, T. O.; Altshuler, I.; de Leon, A. V. P.; Walter, J.; McGovern, E.; Keogh, K.; Martin, C.; Bernard, L.; Fougere, H.; Morgavi, D. P.; Park, T.; Firkins, J. L.; Yu, Z.; Hvidsten, T. R.; Waters, S. M.; Popova, M.; Arntzen, M.; Hagen, L. H.; Pope, P. B.
10.1101/2022.06.22.497163 — microbiology — Posted on 2022-06-24
980 DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts
Strand, S. H.; Rivero-Gutierrez, B.; Houlahan, K. E.; Seoane, J. A.; King, L. M.; Risom, T.; Simpson, L. A.; Vennam, S.; Khan, A.; Cisneros, L.; Hardman, T.; Harmon, B.; Couch, F.; Gallagher, K.; Kilgore, M.; Wei, S.; DeMichele, A.; King, T.; McAuliffe, P. F.; Nangia, J.; Lee, J.; Tseng, J.; Storniolo, A. M.; Thompson, A. M.; Gupta, G. P.; Burns, R.; Veis, D. J.; DeSchryver, K.; Zhu, C.; Matusiak, M.; Wang, J.; Zhu, S. X.; Tappenden, J.; Ding, D. Y.; Zhang, D.; Luo, J.; Jiang, S.; Varma, S.; Anderson, L.; Straub, C.; Srivastava, S.; Curtis, C.; Tibshirani, R.; Angelo, R. M.; Hall, A.; Owzar, K
10.1101/2021.06.16.448585 — cancer biology — Posted on 2022-06-23
983 Structural determinants of homophilic adhesion by receptor tyrosine phosphatases
Hay, I. M.; Shamin, M.; Caroe, E. R.; Mohammed, A. S. A.; Svergun, D. I.; Jeffries, C. M.; Graham, S. C.; Sharpe, H. J.; Deane, J. E.
10.1101/2022.06.23.497309 — biochemistry — Posted on 2022-06-23
985 Evolution of Carbon Isotope Fractionation in Cyanobacteria
Wang, R. Z.; Nichols, R. J.; Liu, A. K.; Flamholz, A. I.; Banda, D. M.; Savage, D. F.; Eiler, J. M.; Shih, P. M.; Fischer, W. W.
10.1101/2022.06.22.497258 — evolutionary biology — Posted on 2022-06-23
987 Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.
Siepe, D. H.; Henneberg, L. T.; Wilson, S. C.; Hess, G. T.; Bassik, M. C.; Zinn, K.; Garcia, K. C.
10.1101/2022.06.22.497261 — cell biology — Posted on 2022-06-23
988 Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions
Hu, W.; Kumar, A.; Qi, S.; Sadras, T.; Casan, J. M.; Ma, D.; Brown, L. M.; Haber, M.; Voskoboinik, I.; Trapani, J. A.; Ekert, P. G.; Fareh, M.
10.1101/2022.06.22.497105 — molecular biology — Posted on 2022-06-23
990 Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4+ helper and CD8+ effector T cells
Azevedo-Pouly, A. C.; Appell, L. E.; Burdine, L.; Rogers, L. J.; Morehead, L. C.; Barker, M.; Waldrip, Z. J.; Koss, B.; Burdine, M. S.
10.1101/2022.06.23.497236 — immunology — Posted on 2022-06-23
992 EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
Chibaya, L.; Murphy, K. C.; Lopez-Diaz, Y.; DeMarco, K. D.; Liu, H.; Gopalan, S.; Faulkner, M.; Li, J.; Morris, J. P.; Ho, Y.-J.; Simon, J.; Luan, W.; Kulick, A.; De Stanchina, E.; Simin, K.; Zhu, L. J.; Fazzio, T. G.; Lowe, S. W.; Ruscetti, M.
10.1101/2022.06.21.495523 — cancer biology — Posted on 2022-06-23
993 Nanopore Fingerprinting of Supramolecular DNA Nanostructures
Confederat, S.; Sandei, I.; Mohanan, G.; Walti, C.; Actis, P.
10.1101/2022.06.23.496947 — biophysics — Posted on 2022-06-23
994 Natural Antimicrobial Peptides Self-assemble as α/β Chameleon Amyloids
Ragonis-Bachar, P.; Rayan, B.; Barnea, E.; Engelberg, Y.; Upcher, A.; Landau, M.
10.1101/2022.06.23.497336 — biophysics — Posted on 2022-06-23
998 A database of accurate electrophoretic migration patterns for human proteins in cell lines.
Mylonas, R.; Potts, A.; Waridel, P.; Barblan, J.; Rubio, M. d. C. C.; Widmann, C.; Quadroni, M.
10.1101/2022.06.22.496709 — biochemistry — Posted on 2022-06-23
1001 Metabotyping of Andean pseudocereals and characterization of emerging mycotoxins
Vásquez-Ocmín, P.; Marti, G.; Gadea, A.; Cabanac, G.; Vásquez-Briones, J. A.; Casavilca-Zambrano, S.; Ponts, N.; Jargeat, P.; Haddad, M.; Bertani, S.
10.1101/2022.06.23.497323 — biochemistry — Posted on 2022-06-23
1003 Mouse genomic rewriting and tailoring: synthetic Trp53 and humanized ACE2
Zhang, W.; Golynker, I.; Brosh, R.; Wudzinska, A. M.; Zhu, Y.; Carrau, L.; Damani-Yokota, P.; Khairallah, C.; Chalhoub, N.; Huang, E.; Ashe, H.; Khanna, K. M.; Maurano, M. T.; Kim, S. Y.; tenOever, B. R.; Boeke, J. D.
10.1101/2022.06.22.495814 — genomics — Posted on 2022-06-23
1005 Ribosomal RNA operons define a central functional compartment in the Streptomyces chromosome
Lorenzi, J.-N.; Thibessard, A.; Lioy, V. S.; Boccard, F.; Leblond, P.; Pernodet, J.-L.; Bury-Mone, S. G.
10.1101/2022.06.23.497307 — genomics — Posted on 2022-06-23
1006 The effects of nitrogen deposition, grazing and land use on Danish acidic grasslands
Heltborg, W.; Danielsen, S. R. W.; Haugaard-Christensen, M.; Damgaard, C. F.
10.1101/2022.06.21.493892 — ecology — Posted on 2022-06-23
1010 SUMO Activated Target Traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome.
Salas-Lloret, D.; van der Meulen, C.; Nagamalleswari, E.; Gracheva, E.; de Ru, A. H.; Otte, H. A.; van Veelen, P. A.; Pichler, A.; Goedhart, J.; Vertegaal, A. C. O.; Gonzalez-Prieto, R.
10.1101/2022.06.22.497173 — molecular biology — Posted on 2022-06-23
1012 A novel inovirus reprograms metabolism and motility of marine Alteromonas
Jia, K.; Peng, Y.; Chen, X.; Jian, H.; Jin, M.; Yi, Z.; Su, M.; Dong, X.; Yi, M.
10.1101/2022.06.23.497286 — microbiology — Posted on 2022-06-23
1013 Structural stability of Human serum albumin is modified in rheumatoid arthritis
Lin, H.-J. L.; Parkinson, D. H.; Holman, J. C.; Thompson, W. C.; Anderson, C. N. K.; Hadfield, M.; Ames, S.; Zuniga Pina, N. R.; Bowden, J. N.; Quinn, C.; Hansen, L. D.; Price, J. C.
10.1101/2022.06.23.497357 — biochemistry — Posted on 2022-06-23
1014 Designed high-redox potential laccases exhibit high functional diversity
Barber-Zucker, S.; Mateljak, I.; Goldsmith, M.; Kupervaser, M.; Alcalde, M.; Fleishman, S. J.
10.1101/2022.06.22.497129 — biochemistry — Posted on 2022-06-23
1016 A taste for numbers: Caenorhabditis elegans foraging follows a low-dimensional rule of thumb
Madirolas, G.; Al-Asmar, A.; Gaouar, L.; Marie-Louise, L.; Garza-Enriquez, A.; Khona, M.; Ratzke, C.; Gore, J.; Perez-Escudero, A.
10.1101/2022.06.21.496406 — animal behavior and cognition — Posted on 2022-06-23
1017 HNRNPA2B1 controls an unfolded protein response-related prognostic gene signature in prostate cancer
Foster, J. G.; Gea, E. E. M.; Labiba, M. A.; Anene, C. A.; Stockley, J.; Philippe, C.; Cereda, M.; Rouault-Pierre, K.; Leung, H. Y.; Bessant, C.; Rajan, P.
10.1101/2022.06.21.495112 — cancer biology — Posted on 2022-06-23
1019 Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers
Castrillon, C.; Simoni, L.; van den Broek, T.; van der Poel, C.; Akama-Garren, E. H.; Ma, M.; Carroll, M. C.
10.1101/2022.06.21.496939 — immunology — Posted on 2022-06-23
1022 S373P Mutation of Spike Protein in SARS-CoV-2 Stabilizes Omicron
Zheng, B.; Xiao, Y.; Tong, B.; Mao, Y.; Ge, R.; Tian, F.; Dong, X.; Zheng, P.
10.1101/2022.06.22.497114 — biophysics — Posted on 2022-06-23
1024 DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics
Robertson, G. L.; Riffle, S. N.; Patel, M.; Marshall, A.; Beasley, H.; Garza-Lopez, E.; Shao, J.; Vue, Z.; Stoll, M. S.; de Wet, S.; Theart, R. P.; Loos, B.; Hinton, A.; Mears, J. A.; Gama, V.
10.1101/2021.12.31.474637 — cell biology — Posted on 2022-06-23
1025 Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance
Spielvogel, E.; Lee, S.-K.; Zhou, S.; Lockbaum, G. J.; Henes, M.; Sondgeroth, A.; Kosovrasti, K.; Nalivaika, E.; Ali, A.; Yilmaz, N. K.; Schiffer, C. A.; Swanstrom, R.
10.1101/837120 — microbiology — Posted on 2022-06-23
1026 White Matter Signals Reflect Information Transmission Between Brain Regions During Seizures
Revell, A. Y.; Silva, A. B.; Mahesh, D.; Armstrong, L.; Arnold, T. C.; Bernabei, J. M.; Gleichgerrcht, E.; Bonilha, L.; Stein, J. M.; Das, S. R.; Shinohara, R. T.; Bassett, D. S.; Litt, B.; Davis, K. A.
10.1101/2021.09.15.460549 — neuroscience — Posted on 2022-06-23
1031 Episodic memory formation in naturalistic viewing
Nikolaev, A. R.; Bramao, I.; Johansson, R.; Johansson, M.
10.1101/2022.05.24.485821 — neuroscience — Posted on 2022-06-23
1032 DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection
Hausmann, F.; Ergen, C.; Khatri, R.; Marouf, M.; Hänzelmann, S.; Gagliani, N.; Huber, S.; Machart, P.; Bonn, S.
10.1101/2022.03.09.483600 — bioinformatics — Posted on 2022-06-23
1033 Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models
Petcherski, A.; Sharma, M.; Satta, S.; Daskou, M.; Vasilopoulos, H.; Hugo, C.; Ritou, E.; Dillon, B. J.; Fung, E.; Garcia, G.; Scafoglio, C.; Purkayastha, A.; Gomperts, B.; Fishbein, G. A.; Arumugaswami, V.; Liesa, M.; Shirihai, O. S.; Kelesidis, T.
10.1101/2022.02.22.481100 — microbiology — Posted on 2022-06-23
1034 Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection
Farjo, M.; Koelle, K.; Martin, M. A.; Gibson, L. L.; Walden, K. K.; Rendon, G.; Fields, C. J.; Alnaji, F.; Gallagher, N.; Luo, C. H.; Mostafa, H. H.; Manabe, Y. C.; Pekosz, A.; Smith, R. L.; McManus, D. D.; Brooke, C. B.
10.1101/2022.06.21.497047 — microbiology — Posted on 2022-06-23
1035 Both social environment and chronological age shape the physiology of ant workers.
Quque, M.; Brun, C.; Villette, C.; Sueur, C.; Criscuolo, F.; Heintz, D.; Bertile, F.
10.1101/2022.06.13.495886 — physiology — Posted on 2022-06-23
1038 VPS13A and VPS13C influence lipid droplet abundance
Chen, S.; Roberts, M. A.; Chen, C.-Y.; Markmiller, S.; Wei, H.-G.; Yeo, G. W.; Granneman, J. G.; Olzmann, J. A.; Ferro-Novick, S.
10.1101/2022.06.21.497109 — cell biology — Posted on 2022-06-23
1039 ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia
Kreider-Letterman, G.; Castillo, A.; Mahlandt, E. K.; Goedhart, J.; Rabino, A. F.; Goiocoechea, S. M.; Garcia-Mata, R.
10.1101/2022.06.22.497207 — cell biology — Posted on 2022-06-23
1046 Single-cell dissection of a collective behaviour in honeybees
Traniello, I. M.; Bukhari, S. A.; Dibaeinia, P.; Serrano, G.; Avalos, A.; Cash-Ahmed, A. C.; Sankey, A.; Hernaez, M.; Sinha, S.; Zhao, S. D.; Catchen, J. M.; Robinson, G. E.
10.1101/2022.03.29.486106 — genomics — Posted on 2022-06-23
1047 Genomic signatures of host-specific selection in a parasitic plant
Bellis, E. S.; von Munchow, C. S.; Kronberger, A.; Odero, C. O.; Kelly, E. A.; Xia, T.; Huang, X.; Wicke, S.; Runo, S. M.; dePamphilis, C. W.; Lasky, J. R.
10.1101/2022.02.01.478712 — evolutionary biology — Posted on 2022-06-23
1049 Sensorimotor feedback loops are selectively sensitive to reward
Codol, O.; Kashefi, M.; Forgaard, C. J.; Galea, J. M.; Pruszynski, J. A.; Gribble, P. L.
10.1101/2021.09.16.460659 — neuroscience — Posted on 2022-06-23
1051 Brain aerobic glycolysis and resilience in Alzheimer disease
Goyal, M. S.; Blazey, T.; Metcalf, N.; McAvoy, M. P.; Strain, J.; Rahmani, M.; Durbin, T.; Xiong, C.; Benzinger, T. L. S.; Morris, J. C.; Raichle, M. E.; Vlassenko, A. G.
10.1101/2022.06.21.497006 — neuroscience — Posted on 2022-06-23
1054 Oxidative stress potentiates the therapeutic action of a mitochondrial complex I inhibitor in MYC-driven B-cell lymphoma
Donati, G.; Nicoli, P.; Verrecchia, A.; Vallelonga, V.; Croci, O.; Rodighiero, S.; Audano, M.; Cassina, L.; Ghsein, A.; Binelli, G.; Boletta, A.; Mitro, N.; Amati, B.
10.1101/2022.06.21.497021 — cancer biology — Posted on 2022-06-23
1055 Single molecule tracking the uncoupling of assembly and membrane insertion in Perfringolysin O
Senior, M. J.; Monico, C.; Weatherill, E. E.; Gilbert, R.; Heuck, A.; Wallace, M. I.
10.1101/2021.05.26.445776 — biophysics — Posted on 2022-06-23
1056 Extracting and characterizing protein-free megabasepair DNA for in vitro experiments
Holub, M.; Birnie, A.; Japaridze, A.; van der Torre, J.; den Ridder, M.; de Ram, C.; Pabst, M.; Dekker, C.
10.1101/2022.06.22.497140 — biophysics — Posted on 2022-06-23
1057 Differences in the structure of plant polygalacturonases specify enzymes dynamics and processivities to fine-tune pectins and root development
Safran, J.; Tabi, W.; Ung, V.; Lemaire, A.; Habrylo, O.; Bouckaert, J.; Rouffle, M.; Voxeur, A.; Pongrac, P.; Bassard, S.; Molinie, R.; Fontaine, J.-X.; Pilard, S.; Pau-Roblot, C.; Bonnin, E.; Larsen, D. S.; Morel-Rouhier, M.; Girardet, J.-M.; LEFEBVRE, V.; Senechal, F.; Mercadante, D.; PELLOUX, J.
10.1101/2022.06.22.497136 — biochemistry — Posted on 2022-06-23
1059 The unfolded protein response transcription factor XBP1s ameliorates Alzheimer`s disease by improving synaptic function and proteostasis
Duran Aniotz, C.; Rivera Krstulovic, C.; Poblete, N.; Ardiles, A. O.; Diaz Hung, M. L.; Sabusap, C. M. P.; Gerakis, Y.; Cabral Miranda, F.; Diaz, J.; Fuentealba, M.; Munoz, E.; Espinosa, S.; Matinez, G.; Quiroz, G.; Tamburini, G.; Medinas, D. B.; Contreras, D.; Lourenco, M. V.; Ribeiro, F. C.; Ferreira, S. T.; Rozas, C.; Morales, B.; Plate, L.; Gonzalez Billault, C.; Palacios, A. G.; Hetz, C.
10.1101/2022.06.21.496869 — animal behavior and cognition — Posted on 2022-06-23
1060 Cancer cells survival is dependent on the lincRNA JUNI
Kumar, V.; Sabate-Cadenas, X.; Soni, I.; Stern, E.; Vias, C.; Ginsberg, D.; Dodel, M.; Mardakheh, F. K.; Shkumatava, A.; Shaulian, E.
10.1101/2022.06.21.496924 — cell biology — Posted on 2022-06-22
1064 Vertical and horizontal transmission of cell fusing agent virus in Aedes aegypti
Logan, R. A.; Quek, S.; Muthoni, J. N.; von Eicken, A.; Brettell, L. E.; Anderson, E. R.; Villena, M. E.; Hegde, S.; Patterson, G. T.; Heinz, E.; Hughes, G. L.; Patterson, E. I.
10.1101/2022.05.26.493619 — microbiology — Posted on 2022-06-22
1065 Genetically-linked simultaneous overexpression of multiple herbicide-metabolizing genes for broad-spectrum resistance in an agricultural weed Echinochloa phyllopogon
Suda, H.; Kubo, T.; Yoshimoto, Y.; Tanaka, K.; Tanaka, S.; Uchino, A.; Azuma, S.; Hattori, M.; Yamaguchi, T.; Miyashita, M.; Tominaga, T.; Iwakami, S.
10.1101/2022.01.02.474499 — plant biology — Posted on 2022-06-22
1067 OrganelX Web Server for Sub-Peroxisomal and Sub-Mitochondrial protein localisation
Anteghini, M.; Haja, A.; Martins dos Santos, V. A. P.; Schomaker, L. R. B.; Saccenti, E.
10.1101/2022.06.21.497045 — bioinformatics — Posted on 2022-06-22
1069 Learning to Control Complex Rehabilitation Robot Using High-Dimensional Interfaces
Lee, J. M.; Gebrekristos, T.; De Santis, D.; Nejati Javaremi, M.; Gopinath, D.; Parikh, B.; Mussa-Ivaldi, F. A.; Argall, B. D.
10.1101/2022.03.07.483341 — bioengineering — Posted on 2022-06-22
1072 Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan.
Garcia, G.; Bar-Ziv, R.; Dutta, N.; Moaddeli, D.; Averbukh, M.; Torres, T. C.; Alcala, A.; Tsui, C. K.; Moehle, E. A.; Shalem, O.; Thorwald, M.; Higuchi-Sanabria, R.
10.1101/2022.06.22.497249 — cell biology — Posted on 2022-06-22
1073 Enhancement of mitochondrial function fosters B cell immune memory
Shukla, A.; Tiwari, A.; Saulnier, O.; Hendrikse, L. D.; Hall, B.; Rickert, R.; Taylor, M.; Shukla, V.; Bagchi, A.
10.1101/2022.06.21.497040 — immunology — Posted on 2022-06-22
1078 Germline Transmission of a Circular Human Artificial Chromosome in the Mouse
Wudzinska, A.; Mitchell, L. A.; Brosh, R.; Bosco, N.; Boccalatte, F.; Aifantis, I.; Kim, S. Y.; Davoli, T.; Boeke, J. D.
10.1101/2022.06.22.496420 — synthetic biology — Posted on 2022-06-22
1079 Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia
Errazquin, R.; Page, A.; Sunol, A.; Segrelles, C.; Carrasco, E.; Peral, J.; Garrido-Aranda, A.; Del Marro, S.; Ortiz, J.; Lorz, C.; Minguillon, J.; Surralles, J.; Belendez, C.; Alvarez, M.; Balmana, J.; Bravo, A.; Ramirez, A.; Garcia-Escudero, R.
10.1101/2022.06.05.494848 — cancer biology — Posted on 2022-06-22
1082 Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression
Blayney, J. W.; Francis, H.; Camellato, B. R.; Mitchell, L.; Stolper, R.; Boeke, J.; Higgs, D. R.; Kassouf, M.
10.1101/2022.06.20.496856 — genetics — Posted on 2022-06-22
1083 One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: relation to chromosomal dosage
Vione, B.; Ramacieri, G.; Zavaroni, G.; Piano, A.; La Rocca, G.; Caracausi, M.; Vitale, L.; Piovesan, A.; Gori, C.; Pirazzoli, G.; Strippoli, P.; Cocchi, G.; Corvaglia, L. T.; Locatelli, C.; Pelleri, M. C.; Antonaros, F.
10.1101/2021.11.30.470411 — genetics — Posted on 2022-06-22
1087 Cytoplasmic membrane thinning observed by interfacial dyes is likely a common effect of bactericidal antibiotics
Dubey, A. K.; Verma, T.; Sardana, D.; Khamari, B.; Alam, P.; Eswarappa, P. B.; Sen, S.; Nandi, D.
10.1101/2022.06.22.497132 — microbiology — Posted on 2022-06-22
1088 Brain histone beta-hydroxy-butyrylation couples metabolism with gene expression
Cornuti, S.; Chen, S.; Lupori, L.; Finamore, F.; Samad, M.; Raimondi, F.; Mazziotti, R.; Magnan, C.; Rocchiccioli, S.; Baldi, P.; Tognini, P.
10.1101/2021.06.28.449924 — neuroscience — Posted on 2022-06-22
1090 spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape
Boniolo, F.; Hoffmann, M.; Roggendorf, N.; Tercan, B.; Baumbach, J.; Castro, M.; Robertson, A. G.; Saur, D.; List, M.
10.1101/2022.03.29.486212 — systems biology — Posted on 2022-06-22
1094 Large retrospective WGS study describes three major sequence types of S. aureus in India and reveals two novel multi-drug resistant sub-lineages of S. aureus Clonal Complex 22
Abrudan, M.; Shamanna, V.; Prasanna, A.; Underwood, A.; Argimon, S.; Nagaraj, G.; Gregorio, S. D.; Govindan, V.; Kodlipet, A.; Sravani, D.; Kekre, M.; Aanensen, D.; L, R. K.
10.1101/2022.06.21.496943 — genomics — Posted on 2022-06-22
1096 Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry
Ampartzidis, I.; Efstathiou, C.; Paonessa, F.; Wilson, T.; McCann, C.; Greene, N.; Copp, A.; Livesey, F. J.; Elvassore, N.; Giobbe, G. G.; De Coppi, P.; Maniou, E.; Galea, G. L.
10.1101/2022.06.15.496231 — cell biology — Posted on 2022-06-22
1098 Arginine methylation of Puf4 drives diverse protein functions
Kalem, M. C.; Duffy, S. R.; Shen, S.; Kaur, J. N.; Qu, J.; Panepinto, J. C.
10.1101/2022.06.21.497104 — molecular biology — Posted on 2022-06-22
1099 Regulation of heme utilization and homeostasis in Candida albicans
Andrawes, N.; Weissman, Z.; Pinsky, M.; Moshe, S.; Berman, J.; Kornitzer, D.
10.1101/2022.06.22.497059 — microbiology — Posted on 2022-06-22
1100 Sporulation efficiency and spore quality in a human intestinal isolate of Bacillus cereus
Vittoria, M.; Saggese, A.; Barletta, G. D. G.; Castaldi, S.; Isticato, R.; Baccigalupi, L.; Ricca, E.
10.1101/2022.06.22.497182 — microbiology — Posted on 2022-06-22
1102 A gut commensal protist protects against virus-mediated loss of oral tolerance
Siller, M.; Zeng, Y.; Sanchez, L. M.; Brigleb, P. H.; Sangani, K. A.; Rana, M.; Van Der Kraak, L.; Pandey, S. P.; Bender, M. J.; Fitzgerald, B.; Hedden, L.; Fiske, K.; Taylor, G. M.; Rahman, S. A.; Galipeau, H. J.; Mullet, S. J.; Wendell, S. G.; Watkins, S. C.; Bercik, P.; Das, J.; Meisel, M.; Jabri, B.; Dermody, T. S.; Verdu, E. F.; Hinterleitner, R.
10.1101/2022.06.21.497012 — immunology — Posted on 2022-06-22
1103 Enhanced top-down sensorimotor processing in somatic anxiety
Bouziane, I.; Das, M.; Friston, K.; Caballero Gaudes, C.; Ray, D.
10.1101/2021.12.02.471029 — neuroscience — Posted on 2022-06-22
1108 Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3
Peters, C. E.; Schulze-Gahmen, U.; Eckhardt, M.; Jang, G. M.; Xu, J.; Pulido, E. H.; Ott, M.; Gozani, O.; Verba, K. A.; Hüttenhain, R.; Carette, J.; Krogan, N. J.
10.1101/2022.06.22.497068 — biophysics — Posted on 2022-06-22
1112 Existing caribou habitat and demographic models need improvement for Ring of Fire impact assessment: A roadmap for improving the usefulness, transparency, and availability of models for conservation
Dyson, M. E.; Endicott, S.; Simpkins, C.; Turner, J. W.; Avery-Gomm, S.; Johnson, C. A.; Leblond, M.; Neilson, E.; Rempel, R. S.; Wiebe, P.; Baltzer, J. L.; Stewart, F. E. C.; Hughes, J.
10.1101/2022.06.01.494350 — ecology — Posted on 2022-06-22
1113 Ratchet, swivel, tilt and roll: A complete description of subunit rotation in the ribosome
Hassan, A.; Byju, S.; Freitas, F. C.; Roc, C.; Pender, N.; Nguyen, K.; Kimbrough, E. M.; Mattingly, J.; Gonzalez, R. L.; Oliveira, R. J. d.; Dunham, C. M.; Whitford, P. C.
10.1101/2022.06.22.497108 — molecular biology — Posted on 2022-06-22
1116 Co-option of endogenous retroviruses through genetic escape from TRIM28 repression
Enriquez-Gasca, R.; Gould, P. A.; Tunbak, H.; Conde, L.; Herrero, J.; Chittka, A.; Gifford, R.; Rowe, H. M.
10.1101/2022.06.22.497016 — molecular biology — Posted on 2022-06-22
1118 The Saccharina latissima microbiome: algal tissue matters more than region, season, and physiology
Burgunter-Delamare, B.; Rousvoal, S.; Legeay, E.; Tanguy, G.; Fredriksen, S.; Boyen, C.; Dittami, S. M.
10.1101/2022.06.22.497188 — microbiology — Posted on 2022-06-22
1120 The metabolic influence of the core ciliate Entodinium caudatum within the rumen microbiome
Andersen, T.; Altshuler, I.; de Leon, A. V. P.; Walter, J.; McGovern, E.; Keogh, K.; Martin, C.; Bernard, L.; Fougere, H.; Morgavi, D.; Park, T.; Firkins, J.; Yu, Z.; Hvidsten, T. R.; Waters, S.; Popova, M.; Arntzen, M.; Hagen, L. H.; Pope, P.
10.1101/2022.06.22.497163 — microbiology — Posted on 2022-06-22
1123 Genome-resolved analyses show an extensive diversification in key aerobic hydrocarbon-degrading enzymes across bacteria and archaea
Somee, M. R.; Amoozegar, M. A.; Dastgheib, S. M. M.; Shavandi, M.; Maman, L. G.; Bertilsson, S.; Mehrshad, M.
10.1101/2022.06.22.496985 — microbiology — Posted on 2022-06-22
1124 Bacterial profiles of the human placenta from term and preterm deliveries
Theis, K. R.; Winters, A. D.; Romero, R.; Alhousseini, A.; Greenberg, J. M.; Panzer, J.; Galaz, J.; Pacora, P.; Shaffer, Z. D.; Jung, E.; Gomez-Lopez, N.
10.1101/2022.06.21.497119 — microbiology — Posted on 2022-06-22
1126 Heads in the clouds: marine viruses disperse bidirectionally along the natural water cycle
Rahlff, J.; Esser, S. P.; Plewka, J.; Heinrichs, M. E.; Soares, A.; Scarchilli, C.; Grigioni, P.; Wex, H.; Giebel, H.-A.; Probst, A. J.
10.1101/2022.06.21.497027 — microbiology — Posted on 2022-06-22
1127 The ESX-1 substrate PPE68 has a key function in the ESX-1 mediated secretion in Mycobacterium marinum
Damen, M. P. M.; Meijers, A. S.; Keizer, E. M.; Piersma, S. R.; Jimenez, C.; Kuijl, C. P.; Bitter, W.; Houben, E. N. G.
10.1101/2022.06.21.497121 — microbiology — Posted on 2022-06-22
1128 Trajectories for the evolution of bacterial CO2-concentrating mechanisms
Flamholz, A. I.; Dugan, E. J.; Panich, J.; Desmarais, J. J.; Oltrogge, L. M.; Fischer, W. W.; Singer, S. W.; Savage, D. F.
10.1101/2022.06.21.497102 — microbiology — Posted on 2022-06-22
1129 Metabolic traits and the niche of bulk soil bacteria in a Mediterranean grassland
Zhalnina, K.; White, R. A.; de Raad, M.; Deng, K.; Nicora, C. D.; Karaoz, U.; Pett-Ridge, J.; Firestone, M.; Lipton, M. S.; Northen, T.; Brodie, E. L.
10.1101/2022.06.21.497019 — microbiology — Posted on 2022-06-22
1130 Poor remyelination of large lesions is attributable to failed oligodendrocyte progenitor cell recruitment
Cooper, J. J. M.; Polanco, J. J.; Saraswat, D.; Peirick, J.; Seidl, A.; Li, Y.; Ma, D.; Sim, F.
10.1101/2022.01.21.477229 — neuroscience — Posted on 2022-06-22
1139 ztf-16 is a novel heterochronic modulator that opposes adult cell fate in dauer and continuous life histories in Caenorhabditis elegans
Hansen, M. A.; Dahal, A.; Bernstein, T. A.; Kohtz, C.; Ali, S.; Daul, A. L.; Montoye, E. A.; Panzade, G. P.; Alessi, A. F.; Flibotte, S.; Vargas, M. L.; Bourgeois, J.; Brown, C. J.; Kim, J. K.; Rougvie, A. E.; Zinovyeva, A.; Karp, X.
10.1101/2022.06.20.496913 — genetics — Posted on 2022-06-22
1140 Dopaminergic axons track somatic signaling in behaving mice
Azcorra, M.; Gaertner, Z.; Davidson, C.; Ramakrishnan, C.; Fenno, L.; Kim, Y. S.; Deisseroth, K.; Awatramani, R.; Dombeck, D. A.
10.1101/2022.06.20.496872 — neuroscience — Posted on 2022-06-22
1143 Fear in action: Fear conditioning and alleviation through body movements
Alemany-Gonzalez, M.; Wokke, M. E.; Chiba, T.; Narumi, T.; Watanabe, K.; Nakazawa, K.; Imamizu, H.; Koizumi, A.
10.1101/2022.06.20.496915 — neuroscience — Posted on 2022-06-22
1144 Covariations of cerebral blood volume and single neurons discharge during resting state and behavioral visual cognitive tasks in non-human primates
Claron, J.; Provansal, M.; Salardaine, Q.; Tisssier, P.; Dizeux, A.; Deffieux, T.; Picaud, S.; Tanter, M.; Arcizet, F.; Pouget, P.
10.1101/2022.06.20.496840 — neuroscience — Posted on 2022-06-22
1148 Non-random distribution of mitochondrial m.3243A>G heteroplasmy in human retina and its impact on cellular phenotype
Mullin, N. K.; Voigt, A. P.; Flamme-Wiese, M. J.; Liu, X.; Riker, M. J.; Varzavand, K.; Stone, E. M.; Tucker, B. A.; Mullins, R. F.
10.1101/2022.06.20.496449 — genetics — Posted on 2022-06-22
1149 In vivo base editing rescues photoreceptors in a mouse model of retinitis pigmentosa
Yang, Y.; Su, J.; She, K.; Song, L.; Jin, X.; Li, R.; Zhao, Q.; Xiao, J.; Chen, D.; Cheng, H.; Lu, F.; Wei, Y.
10.1101/2022.06.20.496770 — genetics — Posted on 2022-06-22
1150 A metagenomic view on fungal diversity in freshwater lakes
Sanyal, A.; Kluge, M.; Angel Redondo, M.; Buck, M.; Mehrshad, M. M.; L Garcia, S.; Bertilsson, S.; Peura, S.
10.1101/2022.06.20.496890 — ecology — Posted on 2022-06-22
1152 THE MAJOR ROLE OF JUNCTIONAL DIVERSITY IN THE HORSE ANTIBODY REPERTOIRE
Navas, C.; Manso, T.; Martins, F.; Minto, L.; Moreira, R.; Minozzo, J.; Antunes, B.; McDaniel, J.; Vale, A. M.; Ippolito, G. C.; Felicori, L. F.
10.1101/2022.06.20.496904 — immunology — Posted on 2022-06-22
1155 Spatial Atlas of the Mouse Central Nervous System at Molecular Resolution
Shi, H.; He, Y.; Zhou, Y.; Huang, J.; Wang, B.; Tang, Z.; Tan, P.; Wu, M.; Lin, Z.; Ren, J.; Thapa, Y.; Tang, X.; Liu, A.; Liu, J.; Wang, X.
10.1101/2022.06.20.496914 — neuroscience — Posted on 2022-06-22
1156 "What" and "When" Predictions Modulate Auditory Processing in a Contextually Specific Manner
Cappotto, D.; Luo, D.; Lai, H. W.; Peng, F.; Melloni, L.; Auksztulewicz, R.; Schnupp, J. W. H.
10.1101/2022.06.20.496917 — neuroscience — Posted on 2022-06-22
1158 Semantic novelty modulates neural responses to visual change across the human brain
Nentwich, M.; Leszczynski, M.; Russ, B. E.; Hirsch, L.; Markowitz, N.; Sapru, K.; Schroeder, C. E.; Mehta, A.; Bickel, S.; Parra, L. C.
10.1101/2022.06.20.496467 — neuroscience — Posted on 2022-06-22
1159 Composition of a spatial engram in mouse dentate gyrus
Wilmerding, L. K.; Kondratyev, I.; Ramirez, S.; Hasselmo, M. E.
10.1101/2022.06.20.496824 — neuroscience — Posted on 2022-06-22
1166 The evolution of Monkeypox virus: a genetic and structural analysis reveals mutations in proteins involved in host-pathogen interaction
Benvenuto, D.; Vita, S.; Pascarella, S.; Bianchi, M.; Giovanetti, M.; Cauda, R.; Nicastri, E.; Cassone, A.; Ciccozzi, M.
10.1101/2022.06.22.497195 — bioinformatics — Posted on 2022-06-22
1169 Cochlear implant material effects on inflammatory cell function and foreign body response
Jensen, M. J.; Claussen, A. D.; Higgins, T.; Vielman-Quevado, R.; Mostaert, B.; Xu, L.; Kirk, J.; Hansen, M. R.
10.1101/2022.06.20.496419 — bioengineering — Posted on 2022-06-22
1171 Phylogenomic Analysis of Protein-Coding Genes Resolves Complex Gall Wasp Relationships
Hearn, J.; Gobbo, E.; Nieves-Aldrey, J. L.; Branca, A.; Nicholls, J. A.; Koutsovoulos, G.; Lartillot, N.; Stone, G. N.; Ronquist, F.
10.1101/2022.06.20.496719 — evolutionary biology — Posted on 2022-06-22
1172 Past, present, and future of the Living Planet Index
Ledger, S. E. H.; McRae, L.; Böhm, M.; Almond, R.; Grooten, M.; Clements, C.; Currie, J.; Galewski, T.; Jenkins, M.; Painter, B.; Young, L.; Loh, J.; Deinet, S.; Marconi, V.; Scott-Gatty, K.; Freeman, R.
10.1101/2022.06.20.496803 — ecology — Posted on 2022-06-22
1173 Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection
Farjo, M.; Koelle, K.; Martin, M. A.; Gibson, L. L.; Walden, K. K.; Rendon, G.; Fields, C. J.; Alnaji, F.; Gallagher, N.; Luo, C. H.; Mostafa, H. H.; Manabe, Y. C.; Pekosz, A.; Smith, R. L.; McManus, D. D.; Brooke, C. B.
10.1101/2022.06.21.497047 — microbiology — Posted on 2022-06-22
1175 Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.
Takeshita, M.; Fukuyama, H.; Kamada, K.; Matsumoto, T.; Makino-Okamura, C.; Uchikubo-Kamo, T.; Tomabechi, Y.; Hanada, K.; Moriyama, S.; Takahashi, Y.; Ishigaki, H.; Nakayama, M.; Nguyen, C. T.; Kitagawa, Y.; Itoh, Y.; Imai, M.; Maemura, T.; Furusawa, Y.; Ueki, H.; Iwatsuki-Horimoto, K.; Ito, M.; Yamayoshi, S.; Kawaoka, Y.; Shirouzu, M.; Ishii, M.; Saya, H.; Kondo, Y.; Kaneko, Y.; Suzuki, K.; Fukunaga, K.; Takeuchi, T.
10.1101/2022.06.21.496751 — microbiology — Posted on 2022-06-22
1176 Increased levels of circulating neurotoxic metabolites in patients with mild Covid19
Santiago-Mujika, E.; Heinrich, K.; George, S.; Capan, C. D.; Forton, C.; Madaj, Z.; Burmeister, A. R.; Sims, M.; Pospisilik, A.; Brundin, P.; Graham, S. F.; Brundin, L.
10.1101/2022.06.22.497189 — neuroscience — Posted on 2022-06-22
1177 Optimizing insect metabarcoding using replicated mock communities
Iwaszkiewicz-Eggebrecht, E.; Granqvist, E.; Buczek, M.; Prus, M.; Roslin, T.; Tack, A. J. M.; Andersson, A. F.; Miraldo, A.; Ronquist, F.; Lukasik, P.
10.1101/2022.06.20.496906 — ecology — Posted on 2022-06-22
1182 Episomal editing of synthetic constructs in yeast using CRISPR
Zhao, Y.; Coelho, C.; Lauer, S.; Laurent, J. M.; Brosh, R.; Boeke, J. D.
10.1101/2022.06.21.496881 — synthetic biology — Posted on 2022-06-22
1183 Antibodies to protozoan variable surface antigens induce antigenic variation
Tenaglia, A. H.; Lujan, L. A.; Rios, D. N.; Midlej, V.; Iribarren, P. A.; Molina, C. R.; Berazategui, M. A.; Torri, A.; Saura, A.; Peralta, D. O.; Rodriguez-Walker, M.; Fernandez, E. A.; Petiti, J. P.; Serradell, M. C.; Gargantini, P. R.; Alvarez, V. E.; de Souza, W.; Lujan, H. D.
10.1101/2022.06.21.497077 — microbiology — Posted on 2022-06-22
1184 Designing β-hairpin peptide macrocycles for antibiotic potential
Randall, J. R.; DuPai, C. D.; Cole, T. J.; Davidson, G.; Groover, K. E.; Wilke, C. O.; Davies, B. W.
10.1101/2022.06.21.497034 — biochemistry — Posted on 2022-06-22
1186 The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage
Mansour, F.; Hinze, C.; Telugu, N.; Kresoja, J.; Shaheed, I. B.; Mosimann, C.; Diecke, S.; Schmidt-Ott, K. M.
10.1101/2022.06.20.496810 — developmental biology — Posted on 2022-06-22
1187 Sensorimotor feedback loops are selectively sensitive to reward
Codol, O.; Kashefi, M.; Forgaard, C. J.; Galea, J. M.; Pruszynski, A. J.; Gribble, P. L.
10.1101/2021.09.16.460659 — neuroscience — Posted on 2022-06-22
1188 Non-classical glycosylation determines intracellular trafficking of APP and Aβ production
Kitazume, S.; Tachida, Y.; Iijima, J.; Takahashi, K.; Suzuki, H.; Yamaguchi, Y.; Tanaka, k.; Nakano, M.; Takakura, D.; Kawasaki, N.; Saito, Y.; Manya, H.; Endo, T.
10.1101/2022.06.20.496769 — neuroscience — Posted on 2022-06-22
1191 MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis
Malmierca-Merlo, P.; Sanchez-Garcia, R.; Grillo-Risco, R.; Perez-Diez, I.; Catala-Senent, J. F.; de la Iglesia-Vaya, M.; Hidalgo, M. R.; Garcia-Garcia, F.
10.1101/2021.07.13.451905 — bioinformatics — Posted on 2022-06-22
1192 Assessment of Sex Bias in Housekeeping Gene Expression in Adipose Tissue Through the Massive Analysis of Transcriptomics Data
Guaita-Cespedes, M.; Grillo-Risco, R.; Hidalgo, M. R.; Fernandez-Veledo, S.; Burks, D. J.; de la Iglesia-Vaya, M.; Galan, A.; Garcia-Garcia, F.
10.1101/2021.12.04.471124 — genomics — Posted on 2022-06-22
1194 Motor learning without movement
Kim, O. A.; Forrence, A. D.; McDougle, S. D.
10.1101/2021.08.12.456140 — neuroscience — Posted on 2022-06-21
1195 Synthetic torpor triggers a neuroprotective and regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation.
Squarcio, F.; Hitrec, T.; Piscitiello, E.; Cerri, M.; Giovannini, C.; Martelli, D.; Occhinegro, A.; Taddei, L.; Tupone, D.; Amici, R.; Luppi, M.
10.1101/2022.03.25.485745 — neuroscience — Posted on 2022-06-21
1197 HTSplotter: an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening
Nunes, C.; Anckaert, J.; De Vloed, F.; De Wyn, J.; Durinck, K.; Vandesompele, J.; Speleman, F.; Vermeirssen, V.
10.1101/2021.09.06.459128 — bioinformatics — Posted on 2022-06-21
1199 Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease
Stouffer, K.; Chen, C.; Kulason, S.; Xu, E.; Witter, M.; Ceritoglu, C.; Albert, M.; Mori, S.; Troncoso, J.; Tward, D. J.; Miller, M. I.
10.1101/2022.06.06.494859 — bioengineering — Posted on 2022-06-21
1200 Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination
Lemonidis, K.; Rennie, M. L.; Arkinson, C.; Chaugule, V. K.; Clarke, M.; Streetley, J.; Walden, H.
10.1101/2022.04.07.487446 — biochemistry — Posted on 2022-06-21
1202 The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France
Marin, J.; Clermont, O.; Royer, G.; Mercier-Darty, M.; Decousser, J.-W.; Tenaillon, O.; Denamur, E.; Blanquart, F.
10.1101/2021.06.24.449745 — genomics — Posted on 2022-06-21
1203 The evolution of an RNA-based memory of self in the face of genomic conflict
Pliota, P.; Marvanova, H.; Koreshova, A.; Kaufman, Y.; Tikanova, P.; Krogull, D.; Hagmueller, A.; Widen, S. A.; Handler, D.; Gokcezade, J.; Duchek, P.; Brennecke, J.; Ben-David, E.; Burga, A.
10.1101/2022.06.17.496645 — genetics — Posted on 2022-06-21
1207 The synergistic effects of plants and nitrogen on microbial hitchhiking
Liu, Z.; Wang, Z.; Xia, Q.; Zhou, Q.; Wu, X.; Kong, W.; Lei, W.; Zeng, J.; Liu, C.; Wang, Y.; Chang, W.; Li, Z.; Yang, Y.; Yang, L.; Tan, X.
10.1101/2022.05.09.491057 — microbiology — Posted on 2022-06-21
1208 Assessing Quantitative MRI Techniques using Multimodal Comparisons
Carter, F.; Anwander, A.; Goucha, T.; Adamson, H.; Friederici, A. D.; Lutti, A.; Gauthier, C. J.; Weiskopf, N.; Bazin, P.-L.; Steele, C. J.
10.1101/2022.02.10.479780 — neuroscience — Posted on 2022-06-21
1212 A beary good genome: Haplotype-resolved, chromosome-level assembly of the brown bear (Ursus arctos)
Armstrong, E. E.; Perry, B. W.; Huang, Y.; Garimella, K. V.; Jansen, H. T.; Robbins, C. T.; Tucker, N. R.; Kelley, J. L.
10.1101/2022.06.17.496447 — genomics — Posted on 2022-06-21
1215 Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function
Balazova, M.; Babelova, L.; Durisova, I.; Vesela, P.; Kanovicova, P.; Zahumensky, J.; Malinsky, J.
10.1101/2022.03.18.484854 — cell biology — Posted on 2022-06-21
1217 EGFR inhibition led ROCK activation enhances desmosome assembly and cohesion in cardiomyocytes
Shoykhet, M.; Dervishi, O.; Menauer, P.; Hiermaier, M.; Osterloh, C.; Ludwig, R.; Waschke, J.; Yeruva, S.
10.1101/2022.04.27.489705 — cell biology — Posted on 2022-06-21
1218 Dynactin interaction with AP-2 adaptor complex requires CLIP-170 and autophagy
Tempes, A.; Bogusz, K.; Brzozowska, A.; Weslawski, J.; Macias, M.; Lew, A.; Calka-Kresa, M.; Bernas, T.; Szczepankiewicz, A. A.; Bakun, M.; Rubel, T.; Malik, A. R.; Jaworski, J.
10.1101/2022.06.19.496704 — cell biology — Posted on 2022-06-21
1222 Human thymopoiesis produces polyspecific CD8+ alfa/beta T cells responding to multiple viral antigens
Quiniou, V.; Barennes, P.; Mhanna, V.; Stys, P.; Vantomme, H.; Zhou, Z.; Martina, F.; Coatnoan, N.; Barbie-Sastre, M.; Pham, H. P.; Clemenceau, B.; Vie, H.; Shugay, M.; Six, A.; Brandao, B.; Mallone, R.; Mariotti-Ferrandiz, E.; Klatzmann, D.
10.1101/2020.07.27.223354 — immunology — Posted on 2022-06-21
1223 Transcriptional and cell type profiles of cortical brain regions showing ultradian cortisol rhythm dependent responses to emotional face stimulation
Habets, P. C.; Kalafatakis, K.; Dzyubachyk, O.; van der Werff, S.; Keo, A.; Thakrar, J.; Mahfouz, A.; Pereira, A.; Russell, G.; Lightman, S.; Meijer, O. C.
10.1101/2022.01.05.475032 — neuroscience — Posted on 2022-06-21
1226 MuDoGeR: Multi-Domain Genome Recovery from metagenomes made easy
Nunes da Rocha, U.; Kasmanas, J.; Kallies, R.; Saraiva, J. P.; Brizola Toscan, R.; Stefanic, P.; Bicalho, M. F.; Correa, F. B.; Basturk, M. N.; Fousekis, E.; Barbosa, L. M. V.; Plewka, J.; Probst, A. J.; Baldrian, P.; Stadler, P. F.; CoLlaborative mUlti-domain Exploration of TERRestriAl metagenomes (CLUE-TERRA),
10.1101/2022.06.21.496983 — bioinformatics — Posted on 2022-06-21
1229 M-Risk: A framework for assessing global fisheries management efficacy of sharks, rays, and chimaeras
Sherman, C. S.; Sant, G.; Simpfendorfer, C. A.; Digel, E. D.; Zubick, P.; Johnson, G.; Usher, M.; Dulvy, N. K.
10.1101/2022.05.29.493344 — ecology — Posted on 2022-06-21
1230 Retinoic acid control of pax8 during renal specification of Xenopus pronephros involves hox and meis3
Durant-Vesga, J.; Suzuki, N.; Ochi, H.; Le Bouffant, R.; Eschstruth, A.; Ogino, H.; Umbhauer, M.; Riou, J.-F.
10.1101/2022.06.21.496994 — developmental biology — Posted on 2022-06-21
1232 Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy
Nguyen, B. A.; Afrin, S.; Singh, V.; Ahmed, Y.; Pedretti, R.; Fernandez Ramirez, M. d. C.; Benson, M. D.; Sawaya, M.; Cao, Q.; Boyer, D.; Pope, A.; Wydorski, P. M.; Chhapra, F.; Eisenberg, D. S.; Saelices, L.
10.1101/2022.06.21.496949 — molecular biology — Posted on 2022-06-21
1233 Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET
Dutka, P.; Metskas, L. A.; Hurt, R. C.; Salahshoor, H.; Wang, T.-Y.; Malounda, D.; Lu, G.; Chou, T.-F.; Shapiro, M. G.; Jensen, G. J.
10.1101/2022.06.21.496981 — molecular biology — Posted on 2022-06-21
1235 Microbial community dynamics during a harmful Chrysochromulina leadbeateri bloom
Aalto, N. J.; Schweitzer, H.; Grann-Meyer, E.; Krsmanovic, S.; Svenning, J. B.; Dalheim, L.; Petters, S.; Ingebrigsten, R.; Hulatt, C. J.; Bernstein, H. C.
10.1101/2022.06.21.496960 — microbiology — Posted on 2022-06-21
1236 The coordination of innate and adaptive immunity in bacteria
Fernandez Arias, C.; Acosta, F. J.; Bertocchini, F.; Herrero, M. A.; Fernandez-Arias, C.
10.1101/2022.06.21.496935 — microbiology — Posted on 2022-06-21
1237 Queuine salvaging in the human parasite Entamoeba histolytica
Sarid, L.; Sun, J.; Chittrakanwong, J.; Trebicz-Geffen, M.; Dedon, P.; Ankri, S.
10.1101/2022.06.21.496972 — microbiology — Posted on 2022-06-21
1239 Cortical ripples during NREM sleep and waking in humans
Dickey, C. W.; Verzhbinsky, I. A.; Jiang, X.; Rosen, B. Q.; Kajfez, S.; Eskandar, E. N.; Gonzalez-Martinez, J.; Cash, S. S.; Halgren, E.
10.1101/2021.05.11.443637 — neuroscience — Posted on 2022-06-21
1240 Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity
Sun, S.; Levenstein, D.; Li, B.; Mandelberg, N.; Chenouard, N.; Suutari, B. S.; Sanchez, S.; Tian, G.; Rinzel, J.; Buzsaki, G.; Tsien, R. W.
10.1101/2022.06.18.496642 — neuroscience — Posted on 2022-06-21
1242 "Cheater" particles render the VEGAS platform unsuitable for mammalian directedevolution
Denes, C. E.; Cole, A. J.; Tran, M. T. N.; Khalid, M. K. N. M.; Hewitt, A. W.; Hesselson, D.; Neely, G. G.
10.1101/2022.06.07.495067 — synthetic biology — Posted on 2022-06-21
1246 In silico optimization of RNA-protein interactions for CRISPR-Cas13-based antimicrobials
Park, H.-m.; Park, Y.; Berani, U.; Bang, E.; Vankerschaver, J.; Van Messem, A.; De Neve, W.; Shim, H.
10.1101/2022.06.21.496952 — bioinformatics — Posted on 2022-06-21
1248 Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
Iglesias, F.; Weston, S.; Avila, S. V.; Zhou, H.; Yousef, S.; Fluchel, M.; Morales, E.; Olson, M. L.; Radhakrishnan, S. V.; Atanackovic, D.; Luetkens, T.
10.1101/2022.06.21.496901 — bioengineering — Posted on 2022-06-21
1252 A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
Guay, K. P.; Ibba, R.; Kiappes, J. L.; De Benedictis, M.; Zeni, I.; Le Cornu, J. D.; Hensen, M.; Chandran, A. V.; Kantsadi, A. L.; Caputo, A. T.; Blanco Capurro, J. I.; Bayo, Y.; Hill, J. C.; Hudson, K.; Lia, A.; Vasiljevic, S.; Modenutti, C. P.; Withers, S. G.; Marti, M.; Biasini, E.; Santino, A.; Hebert, D. N.; Zitzmann, N.; Roversi, P.
10.1101/2022.06.21.496940 — biochemistry — Posted on 2022-06-21
1254 Methylation status of VTRNA2-1/nc886 is stable across human populations, monozygotic twin pairs and in majority of somatic tissues
Marttila, S.; Tamminen, H.; Rajic, S.; Mishra, P. P.; Lehtimäki, T.; Raitakari, O.; Kähönen, M.; Kananen, L.; Jylhävä, J.; Hägg, S.; Delerue, T.; Peters, A.; Waldenberger, M.; Kleber, M. E.; März, W.; Luoto, R.; Raitanen, J.; Sillanpää, E.; Laakkonen, E. K.; Heikkinen, A.; Ollikainen, M.; Raitoharju, E.
10.1101/2022.06.21.496995 — molecular biology — Posted on 2022-06-21
1255 The nuclear GAPDH-HMGB cascade in cortical microglia regulates cognitive flexibility
Ramos, A.; Ishizuka, K.; Namkung, H.; Hayes, L. N.; Saito, A.; Sengupta, A.; Srivastava, R.; Calva, C.; Hayashida, A.; Elkins, N.; Palen, T.; Carloni, E.; Tsujimura, T.; Gallego, J. A.; Robinson, D. G.; Malhotra, A. K.; Ikemoto, S.; Rais, R.; Slusher, B. S.; Niwa, M.; Saitoh, T.; Takimoto, E.; Sawa, A.
10.1101/2022.06.21.497065 — molecular biology — Posted on 2022-06-21
1256 Nutrient and moisture limitation reveal keystone metabolites that link switchgrass rhizosphere metabolome and microbiome dynamics
Baker, N. R.; Zhalnina, K.; Yuan, M.; Herman, D.; Ceja-Navarro, J.; Sasse, J.; Jordan, J. S.; Bowen, B. P.; Wu, L.; Fossum, C.; Chew, A.; Fu, Y.; Saha, M.; Zhou, J.; Pett-Ridge, J.; Northen, T.; Firestone, M.
10.1101/2022.06.20.496911 — microbiology — Posted on 2022-06-21
1257 Non-catastrophic collapse of VEEV by lethal mutagenesis
Alejandro, B.; Kim, E. J.; Hwang, J. Y.; Park, J. W.; Smith, M.; Chung, D.
10.1101/2022.06.21.496950 — microbiology — Posted on 2022-06-21
1260 Targeted curation of the gut microbial gene content modulating human cardiovascular disease
Borton, M. A.; Shaffer, M.; Hoyt, D. W.; Jiang, R.; Ellenbogen, J.; Purvine, S. O.; Nicora, C. D.; Eder, E.; Wong, A.; Smulian, A. G.; Lipton, M.; Krzycki, J. A.; Wrighton, K.
10.1101/2022.06.20.496735 — genomics — Posted on 2022-06-21
1262 Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression
Blayney, J. W.; Kassouf, M.; Francis, H.; Camellato, B. R.; Stolper, R.; Higgs, D. R.; Mitchell, L.; Boeke, J.
10.1101/2022.06.20.496856 — genetics — Posted on 2022-06-21
1265 Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection
Bharucha, T.; Gangadharan, B.; Kumar, A.; Myall, A. C.; Ayhan, N.; Pastorino, B.; Chanthongthip, A.; Vongsouvath, M.; Mayxay, M.; Sengvilaipaseuth, O.; Rattanavong, S.; O'Brien, D. P.; Vendrell, I.; Fischer, R.; Kessler, B.; Turtle, L.; de Lamballerie, X.; Dubot-Peres, A.; Newton, P.; Zitzmann, N.; SEAe collaborators,
10.1101/2022.06.19.496758 — microbiology — Posted on 2022-06-21
1267 Cable-free brain imaging with miniature wireless microscopes
Wang, Y.; Ma, Z.; Li, W.; Su, F.; Wang, C.; Xiong, W.; Li, C.; Zhang, C.
10.1101/2022.06.20.496795 — neuroscience — Posted on 2022-06-21
1274 Light-sheet microscopy of network activity in 3D neuronal systems
Wysmolek, P. M.; Kiessler, F. D.; Salbaum, K. A.; Shelton, E. R.; Sonntag, S.; Serwane, F.
10.1101/2022.06.20.496852 — neuroscience — Posted on 2022-06-21
1275 Immediate and Long-Term Effects of Tibial Nerve Stimulation on the Sexual Behavior of Female Rats
Zimmerman, L. L.; Mentzelopoulos, G.; Parrish, H.; Marcu, V. I.; Luma, B. D.; Becker, J. B.; Bruns, T.
10.1101/2022.06.20.496650 — neuroscience — Posted on 2022-06-21
1276 Obesogenic diet induces circuit-specific memory deficits in mice
Bakoyiannis, I.; Ducourneau, E. G.; N'diaye, M.; Fermigier, A.; Ducroix-Crepy, C.; Bosch-Bouju, C.; Coutureau, E.; Trifilieff, P.; Ferreira, G.
10.1101/2022.06.20.496841 — neuroscience — Posted on 2022-06-21
1279 Autophagy degrades myelin proteins and is essential for maintaining CNS myelin homeostasis
Ktena, N.; Kaplanis, S. I.; Kolotuev, I.; Georgilis, A.; Stavroulaki, V.; Kallergi, E.; Nikoletopoulou, V.; Karagogeos, D.; Savvaki, M.
10.1101/2022.06.20.496817 — neuroscience — Posted on 2022-06-21
1290 Dissection of a complex enhancer cluster at the Sox2 locus
Brosh, R.; Coelho, C.; Ribeiro-dos-Santos, A. M.; Hogan, M. S.; Ashe, H. J.; Ellis, G.; Somogyi, N.; Ordonez, R.; Luther, R.; Huang, E.; Boeke, J. D.; Maurano, M. T.
10.1101/2022.06.20.495832 — genomics — Posted on 2022-06-21
1292 Design, development, and preliminary assessment of a novel peripheral intravenous catheter aimed at reducing early failure rates
Doyle, B.; Kelsey, L.; Shelverton, C.; Abbate, G.; Ainola, C.; Carr, P.; Livingstone, S.; Bouquet, M.; Passmore, M.; Wilson, E.; Colombo, S. M.; Sato, K.; Liu, K.; Heinsar, S.; Sato, N.; Wildi, K.; Suen, J.; Fraser, J.; Li Bassi, G.; Keogh, S.
10.1101/2022.06.20.496233 — bioengineering — Posted on 2022-06-21
1294 ct2vl: Converting Ct Values to Viral Loads for SARS-CoV-2 RT-qPCR Test Results
Hill, E.; Yilmaz, F.; Callahan, C. J.; Cheng, A.; Braun, J.; Arnaout, R.
10.1101/2022.06.20.496929 — microbiology — Posted on 2022-06-21
1295 SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D
Lee, M. J.; Leong, M. W.; Rustagi, A.; Beck, A.; Zeng, L.; Holmes, S.; Qi, L. S.; Blish, C. A.
10.1101/2022.06.20.496341 — immunology — Posted on 2022-06-21
1296 Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern
McNamara, R.; Maron, J. S.; Bertera, H. L.; Boucau, J.; Roy, V.; Barczak, A. K.; The Positives Study Staff, ; Franko, N.; Li, J. Z.; McLellan, J. S.; Siedner, M.; Lemieux, J. E.; Chu, H.; Alter, G.
10.1101/2022.06.19.496718 — immunology — Posted on 2022-06-21
1297 Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning
Ouyang, W. O.; Tan, T. J. C.; Lei, R.; Song, G.; Kieffer, C.; Andrabi, R.; Matreyek, K. A.; Wu, N. C.
10.1101/2022.06.20.496903 — biochemistry — Posted on 2022-06-21
1298 The highly expressed ERV1 forms virus-like particles for regulating early embryonic development
Li, W.; Liu, S.; Zhao, J.; Deng, R.; Liu, Y.; Li, H.; Ma, H.; Chen, Y.; Zhang, J.; Wang, Y.; Su, J.; Quan, F.; Liu, X.; Luo, Y.; Zhang, Y.; Liu, J.
10.1101/2022.06.21.496818 — developmental biology — Posted on 2022-06-21
1300 Cancer cells survival is dependent on the lincRNA JUNI
Shaulian, E.; Kumar, V.; Soni, I.; Stern, E.; Ginsberg, D.; Dodel, M.; Mardakheh, F. K.; Vias, C.; Sabate-Cadenas, X.; Shkumatava, A.
10.1101/2022.06.21.496924 — cell biology — Posted on 2022-06-21
1303 A fluorescent perilipin 2 knock-in mouse model visualizes lipid droplets in the developing and adult brain
Madsen, S.; Delgado, A. C.; Cadilhac, C.; Battison, F.; Maillard, V.; Magrinelli, E.; Jabaudon, D.; Telley, L.; Doetsch, F.; Knobloch, M.
10.1101/2022.06.21.496932 — cell biology — Posted on 2022-06-21
1312 Reduced emergent character of neural dynamics in patients with a disrupted connectome
Luppi, A. I.; Mediano, P. I.; Rosas, F. E.; Allanson, J.; Pickard, J.; Williams, G.; Craig, M.; Finoia, P.; Peattie, A. R. D.; Coppola, P.; Menon, D.; Bor, D.; Stamatakis, E. A.
10.1101/2022.06.16.496445 — neuroscience — Posted on 2022-06-21
1315 SEMA: Antigen B-cell conformational epitope prediction using deep transfer learning
Shashkova, T. I.; Umerenkov, D.; Salnikov, M.; Strashnov, P. V.; Konstantinova, A. V.; Lebed, I.; Shcherbinin, D. N.; Asatryan, M. N.; Kardymon, O. L.; Ivanisenko, N. V.
10.1101/2022.06.20.496780 — bioinformatics — Posted on 2022-06-21
1316 An Automated Method for the Assessment of Memory and Learning in Larval Zebrafish
Widder, M. W.; Carbaugh, C. M.; van der Schalie, W. H.; Li, Y.; Pybus, B. S.; Lee, P. J.; Martin, M. L.; Lanteri, C. A.
10.1101/2022.06.16.496439 — animal behavior and cognition — Posted on 2022-06-21
1325 Isolated Grauer's gorilla populations differ in diet and gut microbiome
Michel, A.; Minocher, R.; Niehoff, P.-P.; Li, Y.; Nota, K.; Gadhvi, M. A.; Su, J.; Iyer, N.; Porter, A.; Ngobobo-As-Ibungu, U.; Binyinyi, E.; Pekeyake, R. N.; Parducci, L.; Caillaud, D.; Guschanski, K.
10.1101/2022.01.04.474987 — ecology — Posted on 2022-06-21
1327 The secreted neuronal signal Spock1 regulates the blood-brain barrier
O'Brown, N. M.; Patel, N. B.; Hartmann, U.; Klein, A. M.; Gu, C.; Megason, S. G.
10.1101/2021.10.13.464312 — neuroscience — Posted on 2022-06-21
1328 Can fMRI functional connectivity index dynamic neural communication?
Alonso Martinez, S.; Llera Arenas, A.; Ter Horst, G. T.; Vidaurre, D.
10.1101/2021.07.27.453965 — neuroscience — Posted on 2022-06-21
1330 Adaptative Machine Translation between paired Single Cell Multi Omics Data
Martinez-de-Morentin, X.; Khan, S.; Lehmann, R.; Qu, S.; Maillo, A.; Kiani, N.; Prosper, F.; Tegner, J.; Gomez-Cabrero, D.
10.1101/2021.01.27.428400 — bioinformatics — Posted on 2022-06-21
1331 On the prediction of arginine glycation using artificial neural networks
Que-Salinas, U.; Martinez-Peon, D.; Reyes-Figueroa, A. D.; Ibarra, I.; Scheckhuber, C. Q.
10.1101/2022.06.05.494871 — biochemistry — Posted on 2022-06-21
1333 Modulation of multiple gene clusters expression by a single PAS-LuxR transcriptional regulator
Vicente, C. M.; Payero, T. D.; Rodríguez-García, A.; Barreales, E. G.; de Pedro, A.; Santos-Beneit, F.; Aparicio, J. F.
10.1101/2022.06.10.495441 — microbiology — Posted on 2022-06-21
1335 Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice
Gironda, S. C.; Day, S. M.; Clarke, C. W.; Snipes, J. A.; Nicol, N. I.; Kamran, H.; Vaughan, W.; Macauley, S. L.; Weiner, J. L.
10.1101/2022.02.18.481066 — neuroscience — Posted on 2022-06-21
1337 Engineered gene circuits capable of reinforcement learning allow bacteria to master gameplaying
Racovita, A.; Prakash, S.; Varela, C.; Walsh, M.; Galizi, R.; Isalan, M.; Jaramillo, A.
10.1101/2022.04.22.489191 — synthetic biology — Posted on 2022-06-21
1338 Integrated cytometry with machine learning applied to high-content imaging of human kidney tissue for in-situ cell classification and neighborhood analysis
Winfree, S.; McNutt, A. T.; Khochare, S.; Borgard, T. J.; Barwinska, D.; Sabo, A. R.; Ferkowicz, M. J.; Williams, J. C.; Lingeman, J. E.; Gulbronson, C. J.; Kelly, K. J.; Sutton, T. A.; Dagher, P. C.; Eadon, M. T.; Dunn, K. W.; El-Achkar, T. M.
10.1101/2021.12.27.474025 — physiology — Posted on 2022-06-21
1339 An ex vivo human bone marrow milieu identifies CDH2 as a driver of niche-mediated treatment resistance in leukaemia
Pal, D.; Blair, H.; Boyd, S.; Angel, S.; Nizami, S.; Isa, A.; Beckett, M.; Nelson, R.; Wilson, A.; Singh, M.; Sankar, S.; Tirtakusuma, R.; Nakjang, S.; Knill, C.; Fuller, A.; McNeill, H.; Russell, L.; Schwab, C.; Zhou, P.; Sinclair, P.; Coxhead, J.; Filby, A.; Allan, J.; Halsey, C.; Harrison, C.; Moorman, A.; Heidenreich, O.; Vormoor, J.
10.1101/2021.06.18.448490 — cancer biology — Posted on 2022-06-21
1340 DeNovoCNN: A deep learning approach to de novo variant calling in next generation sequencing data
Khazeeva, G.; Sablauskas, K.; van der Sanden, B.; Steyaert, W.; Kwint, M.; Rots, D.; Hinne, M.; van Gerven, M.; Yntema, H.; Vissers, L.; Gilissen, C.
10.1101/2021.09.20.461072 — bioinformatics — Posted on 2022-06-21
1341 A MICROFLUIDIC DEVICE FOR LONG-TERM MAINTENANCE OF ORGANOTYPIC LIVER CULTURES
de Hoyos-Vega, J. M.; Hong, H.; Loutherback, K.; Stybayeva, G.; Revzin, A.
10.1101/2022.06.18.496606 — bioengineering — Posted on 2022-06-21
1342 One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: relation to chromosomal dosage
Vione, B.; Ramacieri, G.; Zavaroni, G.; Piano, A.; La Rocca, G.; Caracausi, M.; Vitale, L.; Piovesan, A.; Gori, C.; Pirazzoli, G.; Strippoli, P.; Cocchi, G.; Corvaglia, L. T.; Locatelli, C.; Pelleri, M. C.; Antonaros, F.
10.1101/2021.11.30.470411 — genetics — Posted on 2022-06-21
1343 Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide
Demin, K. A.; Kolesnikova, T. O.; Galstyan, D. S.; Krotova, N. A.; Ilyin, N. P.; Derzhavina, K. A.; Seredinskaya, M.; Kositsyn, Y. M.; Sorokin, D. V.; Nerush, M. O.; Khaybaev, A.-A. S.; Pushkareva, S. A.; Strekalova, T.; Masharsky, A.; Kalueff, A. V.
10.1101/2021.12.05.471274 — neuroscience — Posted on 2022-06-21
1344 Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome
Lee, D.; Chen, W.; Kaku, H. N.; Zhuo, X.; Chao, E. S.; Soriano, A.; Kuncheria, A.; Flores, S.; Kim, J. H.; Rigo, F.; Jafar-nejad, P.; Beaudet, A. L.; Caudill, M. S.; Xue, M.
10.1101/2022.06.18.496687 — neuroscience — Posted on 2022-06-21
1345 Optimization of a Translational Murine Model of Closed-head Traumatic Brain Injury
Mace, B. E.; Lassiter, E.; Arulraja, E. K.; Chaparro, E.; Cantillana, V.; Gupta, R.; Faw, T. D.; Laskowitz, D. T.; Kolls, B. J.
10.1101/2022.06.02.494542 — neuroscience — Posted on 2022-06-21
1352 Exercise preserves fitness capacity during aging through AMPK and mitochondrial dynamics
Campos, J. C.; Bozi, L. H. M.; Traa, A.; van der Bliek, A. M.; Van Raamsdonk, J. M.; Blackwell, T. K.; Ferreira, J. C. B.
10.1101/2022.06.20.496837 — cell biology — Posted on 2022-06-20
1353 Comprehensive Analysis of CRISPR Base Editing Outcomes for Multimeric Protein
Kabra, M.; Moosajee, M.; Newby, G.; Molugu, K.; Saha, K.; Liu, D.; Pattnaik, B. R.
10.1101/2022.06.20.496792 — genetics — Posted on 2022-06-20
1354 Two major epidemics of highly pathogenic avian influenza virus H5N8 and H5N1 in domestic poultry in France, 2020-2022
Lambert, S.; Durand, B.; Andraud, M.; Delacoourt, R.; Scoizec, A.; Le Bouquin, S.; Rautureau, S.; Bauzile, B.; Guinat, C.; Fourtune, L.; Guerin, J.-L.; Paul, M. C.; Vergne, T.
10.1101/2022.06.20.496805 — ecology — Posted on 2022-06-20
1355 Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion
Tajeri, S.; Momeux, L.; Saintpierre, B.; Mfarrej, S.; Chapple, A.; Maurier, T.; Shiels, B.; Ariey, F.; Pain, A.; Langsley, G.
10.1101/2022.06.20.496823 — cell biology — Posted on 2022-06-20
1356 Dynamic Compartmentalisation of Intracellular Sodium in collecting duct cells
Assmus, A. M.; Mullins, L.; Sherborne, C.; Peter, A.; Early, J.; Claeyssens, F.; Haycock, J. W.; Hunter, R.; Mullins, J. J.
10.1101/2022.06.20.496806 — cell biology — Posted on 2022-06-20
1357 Cold-passaged isolates and bat-swine influenza A chimeric viruses as modified live-attenuated vaccines against influenza A viruses in pigs
Graaf, A.; Petric, P. P.; Sehl-Ewert, J.; Henritzi, D.; Breithaupt, A.; King, J.; Pohlmann, A.; Deutskens, F.; Beer, M.; Schwemmle, M.; Harder, T.
10.1101/2022.06.20.496807 — microbiology — Posted on 2022-06-20
1358 Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor
Song, Y.; Nguyen, X.-N.; Kumar, A.; da Silva, C.; Picard, L.; Etienne, L.; CIMARELLI, A.
10.1101/2022.06.20.496826 — microbiology — Posted on 2022-06-20
1360 Analysis of pre-symptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration
Garcia-Vaquero, M.; Heim, M.; Flix, B.; Pereira, M.; Palin, L.; Marques, T. M.; Pinto, F. R.; DE LAS RIVAS, J.; Voigt, A.; Besse, F.; Gama-Carvalho, M.
10.1101/2022.06.20.496821 — neuroscience — Posted on 2022-06-20
1361 Fine-tuning of coumaric acid synthesis to increase naringenin production in yeast
Mao, J.; Mohedano, M. T.; Li, X.; Liu, Q.; Nielsen, J.; Siewers, V.; Chen, Y.
10.1101/2022.06.20.496858 — synthetic biology — Posted on 2022-06-20
1368 Polyalanine disease mutations impair UBA6-dependent ubiquitination
Amer-Sarsour, F.; Falik, D.; Berdichevsky, Y.; Kordonsky, A.; Prag, G.; Vatine, G.; Ashkenazi, A.
10.1101/2022.06.20.496786 — cell biology — Posted on 2022-06-20
1369 Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes
Unapanta, A.; Shavarebi, F.; Porath, J.; Balen, C.; Nguyen, A.; Tseng, J.; Shen, Y.; Liu, M.; Lis, P.; Di Pietro, S.; Hiniker, A.
10.1101/2022.06.20.496629 — cell biology — Posted on 2022-06-20
1371 Anaerobic methane oxidizing archaea offset sediment methane concentrations in Arctic thermokarst lagoons
Yang, S.; Anthony, S. E.; Jenrich, M.; In 't Zandt, M. H.; Strauss, J.; Overduin, P. P.; Grosse, G.; Angelopoulos, M.; Biskaborn, B. K.; Grigoriev, M. N.; Wagner, D.; Knoblauch, C.; Jaeschke, A.; Rethemeyer, J.; Kallmeyer, J.; Liebner, S.
10.1101/2022.06.20.496783 — microbiology — Posted on 2022-06-20
1372 Surface productivity gradients govern changes in abundance and physiological status of deep ocean prokaryotes across the tropical and subtropical Atlantic
Gomez-Letona, M.; Aristegui, J.; Hernandez-Hernandez, N.; Perez-Lorenzo, M.; Alvarez-Salgado, X.-A.; Teira, E.; Sebastian, M.
10.1101/2022.06.20.496789 — microbiology — Posted on 2022-06-20
1374 Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection
Mayo-Munoz, D.; Smith, L. M.; Garcia-Doval, C.; Malone, L. M.; Harding, K. R.; Jackson, S. A.; Hampton, H. G.; Fagerlund, R. D.; Gumy, L. F.; Fineran, P. C.
10.1101/2022.06.20.496707 — microbiology — Posted on 2022-06-20
1375 Components of TOR and MAP kinase signaling control chemotropism and pathogenicity in a fungal pathogen
Vangalis, V.; Markakis, E. A.; Knop, M.; Di Pietro, A.; Typas, M. A.; Papaioannou, I. A.
10.1101/2022.06.20.496898 — microbiology — Posted on 2022-06-20
1378 Molecular interactions underlying the phase separation of HP1: Role of phosphorylation, ligand and nucleic acid binding
Her, C.; Phan, T. M.; Jovic, N.; Kapoor, U.; Ackermann, B. E.; Rizuan, A.; Kim, Y.; Mittal, J.; Debelouchina, G. T.
10.1101/2022.06.20.496886 — biophysics — Posted on 2022-06-20
1380 Novel insights on the contribution of plastoglobules and reactive oxygen species to chromoplast differentiation
Morelli, L.; Torres-Montilla, S.; Glauser, G.; Shanmugabalaji, V.; Kessler, F.; Rodriguez-Concepcion, M.
10.1101/2022.06.20.496796 — plant biology — Posted on 2022-06-20
1383 Exchangeable HaloTag Ligands (xHTLs) for multi-modal super-resolution fluorescence microscopy
Kompa, J.; Bruins, J.; Glogger, M.; Wilhelm, J.; Frei, M. S.; Tarnawski, M.; d'Este, E.; Heilemann, M.; Hiblot, J.; Johnsson, K.
10.1101/2022.06.20.496706 — biochemistry — Posted on 2022-06-20
1384 Demographic history and genetic structure in pre-Hispanic Central Mexico
Villa-Islas, V.; Izarraras-Gomez, A.; Larena, M.; Campos, E. M. P.; Sandoval-Velasco, M.; Rodriguez-Rodriguez, J. E.; Bravo-Lopez, M.; Moguel, B.; Fregel, R.; Tretmanis, J. M.; Velazquez-Ramirez, D. A.; Herrera-Munoz, A.; Sandoval, K.; Nieves-Colon, M. A.; Zepeda, G.; Villanea, F. A.; Medina, E. F. V.; Aguayo-Haro, R.; Valdiosera, C.; Ioannidis, A.; Moreno-Estrada, A.; Jay, F.; Huerta-Sanchez, E.; Sanchez-Quinto, F.; Avila-Arcos, M. C.
10.1101/2022.06.19.496730 — genomics — Posted on 2022-06-20
1385 Epigenetic alterations in gut and brain of adult rats after oral administration of miR-320-3p and miR-375-3p at mid-lactation, and preventive potential of miR-320-3p on early weaning stress.
Tavares, G. A.; Torres, A.; Le Drean, G.; Queignec, M.; Castellano, B.; Tesson, L.; Remy, S.; Anegon, I.; de Souza, S. L.; Pitard, B.; Kaeffer, B.
10.1101/2022.06.20.496755 — genetics — Posted on 2022-06-20
1386 The cohesin subunit RAD21.2 functions as a recombination silencer of ribosomal DNA arrays
Kuttig, V.; Sims, J.; Hamamura, Y.; Komaki, S.; Koehler, M.; Stolze, S. C.; De Jaeger-Braet, J.; Tuncay Elbasy, H.; Nakagami, H.; Failla, A. V.; Schloegelhofer, P.; Schnittger, A.
10.1101/2022.06.20.496767 — cell biology — Posted on 2022-06-20
1388 Oxygen inhibits colibactin production by Escherichia coli
Bossuet-Greif, N.; Guyonnet, C.; Chagneau, C.; Tang-Fichaux, M.; Penary, M.; Branchu, P.; Oswald, E.; Nougayrede, J.-P.
10.1101/2022.06.20.496773 — microbiology — Posted on 2022-06-20
1389 Novel strains of Campylobacter cause diarrheal outbreak in Rhesus macaques (Macaca mulatta) of Kathmandu Valley
Napit, R.; Manandhar, P.; Poudel, A.; Rajbhandari, P. G.; Watson, S.; Shakya, S.; Pradhan, S. M.; Sharma, A. N.; Johnson, C. K.; Mazet, J. K.; Karmacharya, D.
10.1101/2022.06.20.496768 — microbiology — Posted on 2022-06-20
1392 Human concurrent intracranial EEG and fMRI reveals multiple temporally independent but spatially similar connectome trajectories across timescales
Mostame, P.; Wirsich, J.; Alderson, T. H.; Ridley, B.; Carmichael, D.; Vulliemoz, S.; Guye, M.; Lemieux, L.; Sadaghiani, S.
10.1101/2022.06.17.496647 — neuroscience — Posted on 2022-06-20
1395 Lignin Composites with Sustained Oxygenation and Reactive Oxygen Species-Scavenging Improve Neovascularization and Healing of Diabetic Wounds
Padon, B. W.; Olutoye, O. O.; Short, W. D.; Kaul, A. A.; Yutzy, L. D.; Faruk, F.; Jung, O. S.; Kogan, P.; Yu, L.; Li, H.; Jung, J. P.; Balaji, S.
10.1101/2022.06.18.496670 — bioengineering — Posted on 2022-06-20
1398 Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Klughammer, J.; Romanovskaia, D.; Nemc, A.; Posautz, A.; Seid, C.; Schuster, L. C.; Keinath, M. C.; Lugo Ramos, J. S.; Kosack, L.; Evankow, A.; Prinz, D.; Kirchberger, S.; Erguner, B.; Datlinger, P.; Fortelny, N.; Schmidl, C.; Farlik, M.; Skjaerven, K.; Bergthaler, A.; Liedvogel, M.; Thaller, D.; Burger, P. A.; Hermann, M.; Distel, M.; Distel, D. L.; Kubber-Heiss, A.; Bock, C.
10.1101/2022.06.18.496602 — genomics — Posted on 2022-06-20
1408 A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs
Nair, S. S.; Muddapu, V. R.; C, V.; Balasubramani, P. P.; Mishra, J.; Ramanathan, D. S.; Chakravarthy, V. S.
10.1101/2022.06.17.496500 — neuroscience — Posted on 2022-06-20
1409 A non-lemniscal thalamic interface connecting alerting sensory cues to internal states in mice
Wang, Y.; You, L.; Tan, K. M.; Li, M.; Zou, J.; Hu, W.; Li, T.; Yuan, R.; Xie, F.; Xin, F.; Liu, M.; Gao, Y.; Shang, C.; You, Z.; Gao, X.; Xiong, W.; Cao, P.; Luo, M.; Chen, F.; Hong, B.; Yuan, K.
10.1101/2022.06.19.496703 — neuroscience — Posted on 2022-06-20
1411 Host genetic variants regulates CCR5 expression on immune cells: a study in people living with HIV and healthy controls
dos Santos, J. C.; Zhang, Z.; van Eekeren, L. E.; Fok, E. T.; Vadaq, N.; van de Wijer, L.; van der Heijden, W.; Koeken, V. A.; Koenen, H. J.; Mhlanga, M.; Netea, M.; van der Ven, A. J.; Li, Y.
10.1101/2022.06.19.496757 — systems biology — Posted on 2022-06-20
1415 Flexible and efficient handling of nanopore sequencing signal data with slow5tools
Samarakoon, H.; Ferguson, J. M.; Jenner, S. P.; Amos, T. G.; Parameswaran, S.; Gamaarachchi, H.; Deveson, I. W.
10.1101/2022.06.19.496732 — bioinformatics — Posted on 2022-06-20
1416 scFLUX: a web server for metabolic flux and variation prediction using transcriptomics data
Zhang, Z.; Chang, W.; Alghamdi, N.; Zhu, H.; Fei, M.; Wan, C.; Lu, A.; Zang, Y.; Xu, Y.; Wu, W.; Cao, S.; Zhang, Y.; Zhang, C.
10.1101/2022.06.18.496660 — bioinformatics — Posted on 2022-06-20
1421 The evolution of an RNA-based memory of self in the face of genomic conflict
Pliota, P.; Marvanova, H.; Koreshova, A.; Kaufman, Y.; Tikanova, P.; Krogull, D.; Hagmueller, A.; Widen, S. A.; Handler, D.; Gokcezade, J.; Duchek, P.; Brennecke, J.; Ben-David, E.; Burga, A.
10.1101/2022.06.17.496645 — genetics — Posted on 2022-06-20
1422 Conservation management strategy impacts inbreeding and genetic load in scimitar-horned oryx
Humble, E.; Stoffel, M. A.; Dicks, K.; Ball, A. D.; Gooley, R. M.; Chuven, J.; Pusey, R.; al Remeithi, M.; Koepfli, K.-P.; Pukazhenthi, B.; Senn, H.; Ogden, R.
10.1101/2022.06.19.496717 — evolutionary biology — Posted on 2022-06-20
1427 Quantum pBac: An effective, high-capacity piggyBac-based gene integration vector system for unlocking gene therapy potential
Hua, W.-K.; Hsu, J. C.; Chen, Y.-C.; Chang, P. S.; Wen, K.-L. K.; Wang, P.-N.; Yu, Y.-S.; Chen, Y.-C.; Cheng, I.-C.; Wu, S. C.-Y.
10.1101/2022.04.29.490002 — cancer biology — Posted on 2022-06-20
1430 Multi-omics analysis demonstrates a critical role for GLP methyltransferase in transcriptional repression during oogenesis
Demond, H.; Hanna, C. W.; Castillo-Fernandez, J.; Santos, F.; Papachristou, E. K.; Segonds-Pichon, A.; Kishore, K.; D'Santos, C. S.; Kelsey, G.
10.1101/2021.12.20.473460 — developmental biology — Posted on 2022-06-20
1431 The RNA-binding landscape of HAX1 protein indicates its involvement in ribosome biogenesis and translation.
Balcarak, A.; Macech-Klicka, E.; Wakula, M.; Tomecki, R.; Goryca, K.; Rydzanicz, M.; Szostakowska-Rodzos, M.; Chmielarczyk, M.; Wisniewska, M.; Lyczek, F.; Helwak, A.; Tollervey, D.; Kudla, G.; Grzybowska, E.
10.1101/2022.01.14.476349 — molecular biology — Posted on 2022-06-20
1432 A GPU-based computational framework that bridges Neuron simulation and Artificial Intelligence
Zhang, Y.; He, G.; Liu, X.; Hjorth, J.; Kozlov, A.; He, Y.; Zhang, S.; Ma, L.; Kotaleski, J.; Tian, Y.; Grillner, S.; Du, K.; Huang, T.
10.1101/2022.06.12.495784 — neuroscience — Posted on 2022-06-20
1434 An innovative approach to using an intensive field course to build scientific and professional skills
Nicotra, A. B.; Geange, S. R.; Abdulbahar, N.; Carle, H.; Catling, A. A.; Garcia, A.; Harris, R. J.; Head, M.; Jin, M.; Whitehead, M. R.; Zurcher, H.; Beckmann, E. A.
10.1101/2021.12.06.471369 — scientific communication and education — Posted on 2022-06-20
1436 Inhibited KdpFABC resides in an E1 off-cycle state
Silberberg, J.; Stock, C.; Hielkema, L.; Corey, R. A.; Rheinberger, J.; Wunnicke, D.; Dubach, V.; Stansfeld, P.; Haenelt, I.; Paulino, C.
10.1101/2022.06.19.496728 — molecular biology — Posted on 2022-06-19
1438 Locus-specific enrichment analysis of 5-hydroxymethylcytosine reveals novel genes associated with breast carcinogenesis
Ramasamy, D.; Rao, A. K. D. M.; Balaiah, M.; Vittal Rangan, A.; Sundersingh, S.; Veluswami, S.; Thangarajan, R.; Mani, S.
10.1101/2022.06.17.496656 — cancer biology — Posted on 2022-06-19
1439 Charting the Spatial Landscape of Cancer Hallmarks
Sibai, M.; Cervilla, S.; Grases, D.; Musulen, E.; Fortian, A.; Romeo, M.; Bernat, A.; Tokheim, C.; Esteller, M.; Barretina, J.; Ding, L.; Bailey, M.; Porta-Pardo, E.
10.1101/2022.06.18.496114 — cancer biology — Posted on 2022-06-19
1444 The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
Zhu, T.; Kala, S.; Guo, J.; Wu, Y.; Chen, H.; Zhu, J.; Wong, K.; Cheung, C.; Huang, X.; Zhao, X.; Lei, T.; Yang, M.; Sun, L.
10.1101/2022.06.17.496581 — neuroscience — Posted on 2022-06-19
1448 Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity.
Vander Mause, E. R.; Baker, J. M.; Dietze, K. A.; Radhakrishnan, S. V.; Olson, M. L.; Iraguha, T.; Davis, P.; Panse, J.; Marvin, J. E.; Steinbach, M.; Ng, D. P.; Lim, C. S.; Atanackovic, D.; Luetkens, T.
10.1101/2021.12.06.471279 — bioengineering — Posted on 2022-06-19
1450 A FRET biosensor, SMART, monitors necroptosis in renal tubular epithelial cells in a cisplatin-induced kidney injury model
Murai, S.; Takakura, K.; Sumiyama, K.; Moriwaki, K.; Terai, K.; Komazawa-Sakon, S.; Yamaguchi, Y.; Mikami, T.; Araki, K.; Ohmuraya, M.; Matsuda, M.; Nakano, H.
10.1101/2022.06.18.496655 — cell biology — Posted on 2022-06-19
1453 Reduction of a heme cofactor initiates N-nitroglycine degradation by NnlA
Strickland, K. A.; Holland, A. A.; Trudeau, A.; Szlamkowicz, I.; Beazley, M. J.; Anagnostopoulos, V. A.; Graham, D. E.; Caranto, J. D.
10.1101/2022.06.19.496723 — biochemistry — Posted on 2022-06-19
1454 A wheat chromosome segment substitution line series supports characterisation and use of progenitor genetic variation
Horsnell, R.; Leigh, F. J.; Wright, T. I.; Burridge, A. J.; Ligeza, A.; Przewieslik-Allen, A. M.; Howell, P.; Uauy, C.; Edwards, K. J.; Bentley, A. R.
10.1101/2022.06.18.496684 — genetics — Posted on 2022-06-19
1455 Novel Rickettsia spp. in two common overwintering North American passerines
Becker, D. J.; Byrd, A.; Smiley, T. M.; Fernandes Marques, M.; Villegas Nunez, J.; Talbott, K. M.; Atwell, J. W.; Volokhov, D. V.; Ketterson, E. D.; Jahn, A. E.; Clark, K. L.
10.1101/2022.06.18.496698 — ecology — Posted on 2022-06-19
1456 Dynactin interaction with AP-2 adaptor complex requires CLIP-170 and autophagy
Tempes, A.; Bogusz, K.; Brzozowska, A.; Weslawski, J.; Macias, M.; Lew, A.; Calka-Kresa, M.; Bernas, T.; Szczepankiewicz, A. A.; Bakun, M.; Rubel, T.; Malik, A. R.; Jaworski, J.
10.1101/2022.06.19.496704 — cell biology — Posted on 2022-06-19
1458 Quantitative whole-tissue 3D imaging reveals bacteria in close association with mouse jejunum mucosa
Poceviciute, R.; Bogatyrev, S. R.; Romano, A. E.; Dilmore, A. H.; Mondragon-Palomino, O.; Takko, H.; Ismagilov, R. F.
10.1101/2022.06.17.496478 — microbiology — Posted on 2022-06-19
1460 Neonatal hepatic myeloid progenitors expand and propagate liver inflammation in mice
Alkhani, A.; Korsholm, C.; Mohamedaly, S.; Levy, C. S.; Duwaerts, C. C.; Pietras, E. M.; Nijagal, A.
10.1101/2022.06.18.496674 — immunology — Posted on 2022-06-19
1461 Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome
Lee, D.; Chen, W.; Kaku, H. N.; Zhuo, X. S.; Chao, E.; Soriano, A.; Kuncheria, A.; Flores, S.; Kim, J. H.; Rigo, F.; Jafar-nejad, P.; Beaudet, A. L.; Caudill, M. S.; Xue, M.
10.1101/2022.06.18.496687 — neuroscience — Posted on 2022-06-19
1462 Binding of a blast fungus Zinc-finger fold effector to a hydrophobic pocket in the host exocyst subunit Exo70 modulates immune recognition in rice
De la Concepcion, J. C.; Fujisaki, K.; Bentham, A. R.; Cruz Mireles, N.; Sanchez de Medina Hernandez, V.; Shimizu, M.; Lawson, D. M.; Kamoun, S.; Terauchi, R.; Banfield, M. J.
10.1101/2022.06.18.496527 — plant biology — Posted on 2022-06-19
1463 Lung endothelium instructs dormancy of susceptible metastatic tumour cells
Jakab, M.; Lee, K. H.; Uvarovskii, A.; Ovchimmikova, S.; Kulkarni, S. R.; Rostalski, T.; Anders, S.; Augustin, H.
10.1101/2022.06.18.496680 — cancer biology — Posted on 2022-06-19
1467 Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
Zhou, Q.; Schirrmann, K.; Doman, E.; Chen, Q.; Singh, N.; Selvaganapathy, P. R.; Bernabeu, M. O.; Jensen, O. E.; Juel, A.; Chernyavsky, I. L.; Krueger, T.
10.1101/2022.06.18.496666 — biophysics — Posted on 2022-06-19
1468 Patterning Fluid Shear Stress Landscapes with Multiphoton Inner Laser Lithography (MILL) for Live Cell Adhesion and Translocation
Lim, Y. J.; Zhang, J.; Lin, H.; Xu, T.; Li, Y.; Zhang, Z.; Hicks, S. M.; Chudinov, I.; Nechipurenko, D. Y.; Gardiner, E. E.; Lee, S.
10.1101/2022.06.17.496569 — bioengineering — Posted on 2022-06-19
1469 A MICROFLUIDIC DEVICE FOR LONG-TERM MAINTENANCE OF ORGANOTYPIC LIVER CULTURES
de Hoyos-Vega, J. M.; Hong, H.; Loutherback, K.; Stybayeva, G.; Revzin, A.
10.1101/2022.06.18.496606 — bioengineering — Posted on 2022-06-19
1471 Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Mihalic, F.; Simonetti, L.; Giudice, G.; Rubin Sander, M.; Lindqvist, R.; Peters, M. B. A.; Benz, C.; Kassa, E.; Badgujar, D.; Inturi, R.; Ali, M.; Krystkowiak, I.; Sayadi, A.; Andersson, E.; Aronsson, H.; Soderberg, O.; Dobritzsch, D.; Petsalaki, E.; Overby, A. K.; Jemth, P.; Davey, N. E.; Ivarsson, Y.
10.1101/2022.06.19.496705 — biochemistry — Posted on 2022-06-19
1472 Deciphering inhibitory mechanism of coronavirus replication through host miRNAs-RNA-dependent RNA polymerase (RdRp) interactome
Morenikeji, O. B.; Adegbaju, M. S.; Okho, O. S.; Babalola, A. E.; Grytsay, A.; Braimah, O. A.; Akinyemi, M. O.; Thomas, B. N.
10.1101/2022.06.18.496304 — genomics — Posted on 2022-06-19
1475 PI3P dependent regulation of cell size by phosphatidylinositol 5-phosphate 4-kinase
Ghosh, A.; Venugopal, A.; Shinde, D.; Sharma, S. M.; Krishnan, M.; Mathre, S.; Krishnan, H.; PADINJAT, R.
10.1101/2022.06.18.496676 — cell biology — Posted on 2022-06-19
1477 Structure of the human heparan sulfate polymerase complex EXT1-EXT2
Leisico, F.; Omeiri, J.; Le Narvor, C.; Beaudouin, J.; Hons, M.; Fenel, D.; Schoehn, G.; Coute, Y.; Bonnaffe, D.; Sadir, R.; Lortat-Jacob, H.; Wild, R.
10.1101/2022.06.19.496623 — molecular biology — Posted on 2022-06-19
1478 Efficient direct and limited environmental transmission of SARS-CoV-2 lineage B.1.22 in domestic cats
Gerhards, N. M.; Gonzales, J. L.; Vreman, S.; Ravesloot, L.; van den Brand, J. M. A.; Doekes, H.; Egberink, H.; Stegeman, A. J.; Oreshkova, N.; van der Poel, W. H. M.; de Jong, M. C. M.
10.1101/2022.06.17.496600 — microbiology — Posted on 2022-06-19
1479 Strong pathogen competition in neonatal gut colonisation
Mäklin, T.; Thorpe, H. A.; Pöntinen, A. K.; Gladstone, R. A.; Shao, Y.; Pesonen, M.; McNally, A.; Johnsen, P. J.; Samuelsen, O.; Lawley, T. D.; Honkela, A.; Corander, J.
10.1101/2022.06.19.496579 — microbiology — Posted on 2022-06-19
1480 Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide is dependent on the resident microbiota
Hoces, D.; Greter, G.; Arnoldini, M.; Moresi, C.; Berent, S.; Kolinko, I.; Bansept, F.; Woller, A.; Häfliger, J.; Martens, E.; Hardt, W.-D.; Loverdo, C.; Slack, E.
10.1101/2022.06.19.496708 — microbiology — Posted on 2022-06-19
1481 An insight into cellulolytic capacity of the Trichoderma harzianum P49P11 revealed by omics approaches
Codima, C. A.; Tomazetto, G.; Persinoti, G. F.; Riano-Pachon, D. M.; Squina, F. M.; da Cruz Pradella, J. G.; da Silva Delabona, P.
10.1101/2022.06.19.496725 — microbiology — Posted on 2022-06-19
1482 Systemic silencing and DNA methylation of a host reporter gene induced by a beneficial fungal root endophyte
Dalakouras, A.; Katsaouni, A.; Avramidou, M.; Dadami, E.; Tsiouri, O.; Vasileiadis, S.; Makris, A.; Georgopoulou, M. E.; Papadopoulou, K. K.
10.1101/2022.06.19.496700 — plant biology — Posted on 2022-06-19
1485 Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1
Moulana, A.; Dupic, T.; Phillips, A. M.; Chang, J.; Nieves, S.; Roffler, A. A.; Greaney, A. J.; Starr, T. N.; Bloom, J. D.; Desai, M. M.
10.1101/2022.06.17.496635 — evolutionary biology — Posted on 2022-06-19
1486 A Multifunctional Anchor for Multimodal Expansion Microscopy
Cui, Y.; Yang, G.; Goodwin, D. R.; O'Flanagan, C. H.; Sinha, A.; Zhang, C.; Kitko, K. E.; Park, D.; Aparicio, S.; IMAXT Consortium, ; Boyden, E. S.
10.1101/2022.06.19.496699 — bioengineering — Posted on 2022-06-19
1488 Shared enhancer gene regulatory networks between wound and oncogenic programs
Floc'hlay, S.; Balaji, R.; Christiaens, V.; Bravo Gonzalez-Blas, C.; De Winter, S.; Hulselmans, G.; De Waegeneer, M.; Quan, X.; Koldere, D.; Atkins, M.; Halder, G.; Classen, A.-K.; Aerts, S.
10.1101/2022.06.17.496596 — cell biology — Posted on 2022-06-19
1489 Molecular origins of genome instability following a single chromosome mis-segregation event
De Feudis, G.; Garribba, L.; Martis, V.; Galli, M.; Dumont, M.; Eliezer, Y.; Wardenaar, R.; Ippolito, M. R.; Iyer, D. R.; Tijhuis, A. E.; Spierings, D. C.; Schubert, M.; Rhind, N.; Foijer, F.; Ben-David, U.; Fachinetti, D.; Doksani, Y.; Santaguida, S.
10.1101/2022.06.19.496702 — cell biology — Posted on 2022-06-19
1490 Arid5a mediates an IL-17-dependent pathway that drives autoimmunity but not antifungal host defense
Taylor, T. C.; Li, Y.; Li, D.-D.; Majumder, S.; McGeachy, M. J.; Biswas, P. S.; Gingras, S.; Gaffen, S.
10.1101/2022.02.14.480386 — immunology — Posted on 2022-06-19
1491 Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity
Sun, S.; Levenstein, D.; Li, B.; Mandelberg, N.; Chenouard, N.; Suutari, B. S.; Sanchez, S.; Tian, G.; Rinzel, J.; Buzsaki, G.; Tsien, R. W.
10.1101/2022.06.18.496642 — neuroscience — Posted on 2022-06-19
1492 A novel fully-automated system for lifelong continuous phenotyping of mouse cognition and behaviour
Ho, H.; Kejzar, N.; Sasaguri, H.; Saito, T.; Saido, T. C.; de Strooper, B.; Bauza, M.; Krupic, J.
10.1101/2022.06.18.496688 — neuroscience — Posted on 2022-06-19
1494 Locus-specific enrichment analysis of 5-hydroxymethylcytosine revealed novel genes associated with breast carcinogenesis
Ramasamy, D.; Rao, A. K. D. M.; Balaiah, M.; Vittal Rangan, A.; Sundersingh, S.; Veluswami, S.; Thangarajan, R.; Mani, S.
10.1101/2022.06.17.496656 — cancer biology — Posted on 2022-06-19
1495 Serial Crystallography with Multi-stage Merging of 1000s of Images
Soares, A.; Yamada, Y.; Jakoncic, J.; McSweeney, S.; Sweet, R. M.; Skinner, J.; Foadi, J.; Fuchs, M. R.; Schneider, D. K.; Shi, W.; Andrews, L. C.; Bernstein, H. J.
10.1101/141770 — bioinformatics — Posted on 2022-06-19
1501 Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance
Simmler, P.; Mengis, T.; Van-Lehmann, K.; Khales, A.; Thomas, T.; Rätsch, G.; Stoffel, M.; Schwank, G.
10.1101/2022.06.16.496393 — cancer biology — Posted on 2022-06-19
1503 The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling
Vormittag, S.; Hüsler, D.; Haneburger, I.; Kroninger, T.; Anand, A.; Prantl, M.; Barisch, C.; Maass, S.; Becher, D.; Letourneur, F.; Hilbi, H.
10.1101/2022.06.17.496549 — microbiology — Posted on 2022-06-19
1504 An open source plant kinase chemogenomics set
Ercoli, M. F.; Zonzini Ramos, P.; Jain, R.; Pilotte, J.; Dong, O. X.; Thompson, T.; Wells, C. I.; Elkins, J. M.; Edwards, A. M.; Counago, R. M.; Drewry, D. H.; Ronald, P. C.
10.1101/2022.06.18.496431 — plant biology — Posted on 2022-06-19
1506 Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation
Schmassmann, P.; Roux, J.; Dettling, S.; Hogan, S.; Shekarian, T.; Martins, T. A.; Ritz, M.-F.; Herter, S.; Bacac, M.; Hutter, G.
10.1101/2022.06.17.496574 — cancer biology — Posted on 2022-06-19
1509 Modular, Cascade-like Transcriptional Program of Regeneration in Stentor
Sood, P.; Lin, A.; Yan, C.; McGillivary, R.; Diaz, U.; makushok, t.; Marshall, W. F.
10.1101/2021.06.23.449623 — cell biology — Posted on 2022-06-19
1510 Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner
Onwubiko, U. N.; Koory, E.; Pokharel, S.; Roberts, H.; Mitoubsi, A.; Das, M. E.
10.1101/2022.06.14.496145 — cell biology — Posted on 2022-06-19
1511 Breathing on Chip: Dynamic flow and stretch tune cellular composition and accelerate mucociliary maturation of airway epithelium in vitro
Nawroth, J. C.; Roth, D.; van Schadewijk, A.; Ravi, A.; Maulana, T. I.; Senger, C. N.; van Riet, S.; Ninaber, D. K.; Kraft, D.; Hiemstra, P. S.; Ryan, A. L.; van der Does, A. M.
10.1101/2021.05.07.443164 — cell biology — Posted on 2022-06-19
1512 Bystander memory-phenotype conventional CD4+ T cells exacerbating autoimmune neuroinflammation
Cho, M.-Z.; Lee, H.-G.; Yoon, J.-W.; Kim, G.-R.; Koo, J.-H.; Taneja, R.; Edelson, B.; Lee, Y. J.; Choi, J.-M.
10.1101/2022.06.17.496529 — immunology — Posted on 2022-06-19
1513 In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis
Godat, T.; Cottaris, N. P.; Patterson, S.; Kohout, K.; Parkins, K.; Yang, Q.; Strazzeri, J. M.; McGregor, J. E.; Brainard, D. H.; Merigan, W. H.; Williams, D. R.
10.1101/2022.02.28.482294 — neuroscience — Posted on 2022-06-19
1514 Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling
LIU, X.; Bae, C.; Liu, B.; Zhang, Y.; Zhou, X.; Zhang, D.; Zhou, C.; DiBua, A.; Schutz, L.; Kaczocha, M.; Puopolo, M.; Yamaguchi, T. P.; Chung, J. M.; Tang, S.-J.
10.1101/2021.06.19.449129 — neuroscience — Posted on 2022-06-19
1515 Starburst amacrine cells amplify optogenetic visual restoration through gap junctions in the murine retina
Katada, Y.; Kunimi, H.; Serizawa, N.; Lee, D.; Kobayashi, K.; Okano, H.; Tanaka, K. F.; Tsubota, K.; Kurihara, T.
10.1101/2020.08.11.246686 — neuroscience — Posted on 2022-06-19
1516 CSF1R inhibitor levels determine sex-specific phenotype of resilient microglia and neurofunctional rescue leading to extended survival in tauopathy mice
Johnson, N. R.; Yuan, P.; Castillo, E.; Lopez, T. P.; Yue, W.; Bond, A.; Rivera, B. M.; Sullivan, M. C.; Hirouchi, M.; Giles, K.; Aoyagi, A.; Condello, C.
10.1101/2021.03.20.436288 — neuroscience — Posted on 2022-06-19
1517 A Distributed Network for Multimodal Experiential Representation of Concepts
Tong, J.-Q.; Binder, J. R.; Humphries, C. J.; Mazurchuk, S.; Conant, L. L.; Fernandino, L.
10.1101/2021.07.05.451188 — neuroscience — Posted on 2022-06-19
1518 Functional network properties derived from widefield calcium imaging differ with wakefulness and across cell type
O'Connor, D.; Mandino, F.; Shen, X.; Horien, C.; Ge, X.; Herman, P.; Crair, M.; Papademetris, X.; Lake, E. M.; Constable, R. T.
10.1101/2022.05.24.493310 — neuroscience — Posted on 2022-06-19
1519 Dietary polyphenols drive alterations in behavior, transcriptional regulation, and commensal microbiota in models of opioid use.
Osman, A.; Hofford, R. S.; Meckel, K. R.; Dave, Y. A.; Zeldin, S. M.; Shipman, A. L.; Lucerne, K. E.; Trageser, K. J.; Oguchi, T.; Pasinetti, G. M.; Kiraly, D. D.
10.1101/2022.06.14.496180 — neuroscience — Posted on 2022-06-19
1522 Dynamical processing of orientation precision in the primary visual cortex
Ladret, H. J.; Cortes, N.; Ikan, L.; Chavane, F.; Casanova, C.; Perrinet, L. U.
10.1101/2021.03.30.437692 — neuroscience — Posted on 2022-06-19
1525 Topological digestion drives time-varying rheology of entangled DNA fluids
Michieletto, D.; Neill, P.; Weir, S.; Evans, D.; Crist, N.; Martinez, V. A.; Anderson, R.
10.1101/2021.06.16.448664 — biophysics — Posted on 2022-06-19
1527 MIDAS2: Metagenomic Intra-species Diversity Analysis System
Zhao, C.; Dimitrov, B.; Goldman, M.; Nayfach, S.; Pollard, K. S.
10.1101/2022.06.16.496510 — bioinformatics — Posted on 2022-06-19
1532 Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules
Hast, K.; Stone, M. R. L.; Jia, Z.; Baci, M.; Aggarwal, T.; Izgu, E. C.
10.1101/2021.10.01.462811 — biochemistry — Posted on 2022-06-19
1533 The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families
Zhong, Y.; Moghaddas Sani, H.; Paudel, B.; Low, J.; Silva, A.; Mueller, S.; Deshpande, C.; Panjikar, S.; Reid, X.; Bedward, M.; van Oijen, A.; Mackay, J.
10.1101/2022.06.13.496015 — biochemistry — Posted on 2022-06-19
1535 Differential requirements for mitochondrial electron transport chain components in the adult murine liver
Lesner, N. P.; Wang, X.; Chen, Z.; Frank, A.; Menezes, C.; House, S.; Shelton, S. D.; McFadden, D. G.; Wansapura, J.; DeBerardinis, R. J.; Mishra, P.
10.1101/2021.07.15.452466 — cell biology — Posted on 2022-06-19
1538 Host genetics maps to behaviour and brain structure in mice
Asbury, S.; Lai, J.; Rilett, K.; Haqqee, Z.; Darwin, B.; Ellegood, J.; Lerch, J.; Foster, J.
10.1101/2022.06.18.495938 — neuroscience — Posted on 2022-06-19
1539 Sparse-spectral microendoscopy for real-time visualization of tumor cell phenotype and microenvironment spatial heterogeneity in vivo
Spring, B. Q.; Palanisami, A.; Saad, M. A.; Kercher, E. M.; Lang, R. T.; Harman, R. C.; Sutin, J.; Mai, Z.; Hasan, T.
10.1101/2022.06.17.496624 — bioengineering — Posted on 2022-06-18
1540 GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Cordova, R.; Misra, J.; Amin, P. H.; Klunk, A. J.; Damayanti, N. P.; Carlson, K. R.; Elmendorf, A. J.; Hyeong-Geug, K.; Mirek, E. T.; Miller, M. J.; Dong, X. C.; Cheng, L.; Anthony, T. G.; Pili, R.; Wek, R. C.; Staschke, K. A.
10.1101/2022.06.17.496598 — cancer biology — Posted on 2022-06-18
1541 Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells
Chew, K.; Lee, B.; Van Haren, S.; Nanishi, E.; O'Meara, T. R.; Splaine, J. B.; De Leon, M.; Soni, D.; Seo, H.-S. R.; Dhe-Paganon, S.; Ozonoff, A.; Smith, J. A.; Levy, O.; Dowling, D. J.
10.1101/2022.06.17.496630 — immunology — Posted on 2022-06-18
1543 The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
ZHU, T.; Kala, S.; Guo, J.; Wu, Y.; Chen, H.; Zhu, J.; Wong, K.; Cheung, C.; Huang, X.; Zhao, X.; Lei, T.; Yang, M.; Sun, L.
10.1101/2022.06.17.496581 — neuroscience — Posted on 2022-06-18
1544 GRINtrode: A neural implant for simultaneous two-photon imaging and extracellular electrophysiology in freely moving animals
McCullough, C. M.; Ramirez-Gordillo, D.; Hall, M.; Futia, G. L.; Moran, A. K.; Gibson, E. A.; Restrepo, D.
10.1101/2022.06.17.496591 — neuroscience — Posted on 2022-06-18
1546 Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5
McComas, S.; Mitrovic, D.; Alleva, C.; Bonaccorsi, M.; Drew, D.; Delemotte, L.
10.1101/2022.06.17.495601 — biophysics — Posted on 2022-06-18
1548 Comparison of missing data handling methods for variant pathogenicity predictors
Särkkä, M. I.; Myöhänen, S.; Marinov, K.; Saarinen, I.; Lahti, L.; Fortino, V.; Paananen, J.
10.1101/2022.06.17.496578 — bioinformatics — Posted on 2022-06-18
1551 Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
Sun, B. B.; Chiou, J.; Traylor, M.; Benner, C.; Hsu, Y.-H.; Richardson, T. G.; Surendran, P.; Mahajan, A.; Robins, C.; Vasquez-Grinnell, S. G.; Hou, L.; Kvikstad, E. M.; Burren, O. S.; Cule, M.; Davitte, J.; Ferber, K. L.; Gillies, C. E.; Hedman, A. K.; Hu, S.; Lin, T.; Mikkilineni, R.; Pendergrass, R. K.; Pickering, C.; Prins, B.; Raj, A.; Robinson, J.; Sethi, A.; Ward, L. D.; Welsh, S.; Willis, C. M.; Alnylam Human Genetics, ; AstraZeneca Genomics Initiative, ; Biogen Biobank Team, ; Bristol Myers Squibb, ; Genentech Human Genetics, ; GlaxoSmithKline Genomic Sciences, ; Pfizer Integrat
10.1101/2022.06.17.496443 — genetics — Posted on 2022-06-18
1557 Preclinical safety evaluation of continuous UV-A lighting in an operative setting
Guenter, R.; Zheng-Pywell, R.; Herring, B.; Murphy, M. S.; Benner, K.; Rose, J. B.
10.1101/2022.06.17.496643 — molecular biology — Posted on 2022-06-18
1562 A beary good genome: Haplotype-resolved, chromosome-level assembly of the brown bear (Ursus arctos)
Armstrong, E. E.; Perry, B. W.; Huang, Y.; Garimella, K. V.; Jansen, H. T.; Robbins, C. T.; Tucker, N. R.; Kelley, J. L.
10.1101/2022.06.17.496447 — genomics — Posted on 2022-06-18
1566 The cIAP ubiquitin ligases sustain type 3 γδ T and innate lymphoid cells during aging to allow normal cutaneous and mucosal responses
Rizk, J.; Morbe, U. M.; Agerholm, R.; Ulmert, I.; Tardos, E. C.; Kadekar, D.; Baglioni, M. V.; Vinals, M. T.; Bekiaris, V.
10.1101/2020.05.14.094334 — immunology — Posted on 2022-06-18
1568 Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments
Higgins, G.; Higgins, F.; Peres, J.; Lang, D. M.; Abdalrahman, T.; Zaman, M.; Prince, S.; Franz, T.
10.1101/2022.06.09.495509 — biophysics — Posted on 2022-06-18
1569 Automated structure-based learning to model co-operativity and protein-DNA interactions in cis-regulatory modules
Fornes, O.; Meseguer, A.; Aguirre-Plans, J.; GOHL, P.; Mireia-Bota, P.; MOLINA-FERNANDEZ, R.; BONET, J.; CHINCHILLA, A.; PEGENAUTE, F.; Gallego, O.; Fernandez-Fuentes, N.; Oliva, B.
10.1101/2022.04.17.488557 — bioinformatics — Posted on 2022-06-18
1570 Macroscale Adipose Tissue from Cellular Aggregates: A Simplified Method of Mass Producing Cell-Cultured Fat for Food Applications
Yuen, J. S.; Saad, M. K.; Xiang, N.; Barrick, B. M.; DiCindio, H.; Li, C.; Zhang, S. W.; Rittenberg, M.; Lew, E. T.; Leung, G.; Pietropinto, J. A.; Kaplan, D. L.
10.1101/2022.06.08.495192 — bioengineering — Posted on 2022-06-18
1571 Deep and fast label-free Dynamic Organellar Mapping
Schessner, J. P.; Albrecht, V.; Davies, A. K.; Sinitcyn, P.; Borner, G. H. H.
10.1101/2021.11.09.467934 — biochemistry — Posted on 2022-06-18
1573 Transcription shapes 3D chromatin organization by interacting with loop extrusion
Banigan, E. J.; Tang, W.; van den Berg, A. A.; Stocsits, R. R.; Wutz, G.; Brandao, H. B.; Busslinger, G. A.; Peters, J.-M.; Mirny, L. A.
10.1101/2022.01.07.475367 — genomics — Posted on 2022-06-18
1576 Genome-wide identification of the LexA-mediated DNA damage response in Streptomyces venezuelae
Stratton, K. J.; Bush, M. J.; Chandra, G.; Stevenson, C. E. M.; Findlay, K.; Schlimpert, S.
10.1101/2022.03.28.486056 — microbiology — Posted on 2022-06-18
1578 In BRAFV600E-mutated colorectal cancer cells, fascin1 restructures adherens junctions to drive Wnt activation
Pham, E.; Esmaeilniakooshkghazi, A.; George, S. P.; Ahrorov, A.; Villagomez, F. R.; Byington, M.; Mukhopadhyay, S.; Patnaik, S.; Conrad, J. C.; Naik, M.; Ravi, S.; Tebbuttt, N.; Mooi, J.; Reehorst, C. M.; Mariadason, J. M.; Khurana, S.
10.1101/2022.06.14.496198 — cancer biology — Posted on 2022-06-18
1582 No reproductive benefits of dear enemy recognition in a territorial songbird
Reichert, M. S.; Crane, J. M. S.; Davidson, G.; Dillane, E.; Kulahci, I.; O'Neill, J.; van Oers, K.; Sexton, C.; Quinn, J.
10.1101/2021.04.28.441816 — animal behavior and cognition — Posted on 2022-06-18
1584 Genomic adaptation in the CAZyome and specialised metabolism of the plant-associated Streptomyces violaceusniger clade
Gayrard, D.; Veyssiere, M.; Nicolle, C.; Adam, K.; Martinez, Y.; Vandecasteele, C.; Vidal, M.; Dumas, B.; Rey, T.
10.1101/2021.10.25.465742 — genomics — Posted on 2022-06-18
1585 Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
Koppes, E. A.; Johnson, M. A.; Moresco, J. J.; Luppi, P.; Lewis, D. W.; Stolz, D. B.; Diedrich, J. K.; Yates, J. R.; Wek, R. C.; Watkins, S. C.; Gollin, S. M.; Park, H. J.; Drain, P.; Nicholls, R. D.
10.1101/2021.12.16.473032 — genetics — Posted on 2022-06-18
1587 TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
Nore, A.; Juarez-Martinez, A. B.; Clement, J. A.; Brun, C.; Diagouraga, B.; Grey, C.; Bourbon, H.-M.; Kadlec, J.; Robert, T.; de Massy, B.
10.1101/2021.11.30.470517 — molecular biology — Posted on 2022-06-17
1591 Alcohol-sourced acetate reduces T cell filamentous actin branching and migration
Azizov, V.; Frech, M.; Hofmann, J.; Kubankova, M.; Lapuente, D.; Tenbusch, M.; Guck, J.; Schett, G.; Zaiss, M. M.
10.1101/2022.03.08.483253 — immunology — Posted on 2022-06-17
1592 Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.
Vigdorovich, V.; Patel, H.; Watson, A.; Raappana, A.; Reynolds, L.; Selman, W.; Beeman, S.; Edlefsen, P. T.; Kappe, S. H. I.; Sather, D. N.
10.1101/2022.06.17.496580 — immunology — Posted on 2022-06-17
1596 The gradient-based parameter optimization to determine membrane ionic current composition of human induced pluripotent stem cell-derived cardiomyocytes
Kohjitani, H.; Koda, S.; Himeno, Y.; Makiyama, T.; Yamamoto, Y.; Yoshinaga, D.; Wuriyanghai, Y.; Kashiwa, A.; Toyoda, F.; Zhang, Y.; Amano, A.; Noma, A.; Kimura, T.
10.1101/2022.05.16.492203 — physiology — Posted on 2022-06-18
1597 Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer
Silberberg, G.; Walling, B.; Wesa, A.; Audia, A.; Sloma, I.; Zeng, Y.; Han, G.; Tabg, J.; Pammer, P.; Bakayoko, A.; Ciznadija, D.; Vishwakarma, B.; Mosesson, Y.; Zipeto, M.; RItchie, M.
10.1101/2022.06.14.495846 — cancer biology — Posted on 2022-06-18
1598 An engineered xCas12i with high activity, high specificity and broad PAM range
Zhang, H.; Kong, X.; Xue, M.; Wang, Z.; Wei, Y.; Wang, H.; Zhou, J.; Zhang, W.; Xu, M.; Shen, X.; Li, J.; Hu, J.; Zhong, N.; Zhou, Y.; Yang, H.
10.1101/2022.06.15.496255 — bioengineering — Posted on 2022-06-17
1599 Genome and transcriptome architecture of allopolyploid okra (Abelmoschus esculentus)
Nieuwenhuis, R.; Hesselinkk, T.; van den Broeck, H. C.; Cordewener, J.; Schijlen, E.; Bakker, L.; Diaz Trivino, S.; Struss, D.; de Hoop, S.-J.; de Jong, H.; Peters, S. A.
10.1101/2021.11.18.469076 — genomics — Posted on 2022-06-17
1600 In vivo seamless genetic engineering via CRISPR-triggered single-strand annealing
Aguilar, G.; Bauer, M.; Vigano, M. A.; Jimenez-Jimenez, C.; Guerrero, I.; Affolter, M.
10.1101/2022.06.17.496589 — genetics — Posted on 2022-06-18
1601 The nucleoporin Nup170 mediates subtelomeric gene silencing through the Ctf18-RFC complex and PCNA
Kumar, S.; Neal, M. L.; Li, S.; Navare, A. T.; Mast, F. D.; Rout, M. P.; Aitchison, J. D.
10.1101/2022.06.17.496627 — cell biology — Posted on 2022-06-17
1602 O-GlcNAc transferase modulates formation of clathrin-coated pits
Rahmani, S.; Ahmed, H.; Ibazebo, O.; Fussner-Dupas, E.; Wakarchuk, W. W.; Antonescu, C. N.
10.1101/2022.06.17.496621 — cell biology — Posted on 2022-06-18
1605 Optimized path planning surpasses human efficiency in cryo-EM imaging
Li, Y.; Fan, Q.; Cohn, J.; Demers, V.; Lee, J. Y.; Yip, L.; Cianfrocco, M. A.; Vos, S. M.
10.1101/2022.06.17.496614 — biophysics — Posted on 2022-06-17
1606 3D single-cell shape analysis of cancer cells using geometric deep learning
De Vries, M.; Dent, L. G.; Curry, N.; Rowe-Brown, L.; Tyson, A. L.; Dunsby, C.; Bakal, C.
10.1101/2022.06.17.496550 — bioinformatics — Posted on 2022-06-17
1613 Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms
Ledsgaard, L.; Wade, J.; Boddum, K.; Oganesyan, I.; Harrison, J.; Jenkins, T. P.; Villar, P.; Leah, R. A.; Zenobi, R.; McCafferty, J.; Lomonte, B.; Gutierrez, J. M.; Laustsen, A. H.; Karatt-Vellatt, A.
10.1101/2022.06.17.496531 — bioengineering — Posted on 2022-06-17
1615 Pan-cancer whole genome comparison of primary and metastatic solid tumors
Martinez-Jimenez, F.; Movasati, A.; Brunner, S.; Nguyen, L.; Priestley, P.; Cuppen, E.; Van Hoeck, A.
10.1101/2022.06.17.496528 — genomics — Posted on 2022-06-17
1620 The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte and ependymal cell-cell coupling
Pelz, L.; Dossou, L.; Kompier, N.; Juttner, R.; Siemonsmeier, G.; Meyer, N.; Lowenstein, E. D.; Lahmann, I.; Kettenmann, H.; Birchmeier, C.; Rathjen, F. G.
10.1101/2022.06.17.496568 — cell biology — Posted on 2022-06-17
1621 Spatacsin regulates directionality of lysosome trafficking
Pierga, A.; Matusiak, R.; Cauhape, M.; Branchu, J.; Boutry, M.; Darios, F.
10.1101/2022.06.17.496577 — cell biology — Posted on 2022-06-17
1622 More than Mycobacterium tuberculosis: specific site-of-disease microbial communities, functional capacities, and their distinct clinical profiles in tuberculous lymphadenitis
Nyawo, G. G.; Naidoo, C. C.; Wu, B.; Sulaiman, I.; Clemente, J. C.; Li, Y.; Minnies, S.; Reeve, B.; Moodley, S.; Rautenbach, C.; Wright, C.; Singh, S.; Whitelaw, A.; Schubert, P.; Warren, R.; Segal, L.; Theron, G.
10.1101/2022.06.16.496073 — molecular biology — Posted on 2022-06-17
1623 Influence of short and long term processes on SAR11 communities in open ocean and coastal systems
Bolanos, L. M.; Tait, K.; Somerfield, P. J.; Parsons, R. J.; Giovannoni, S.; Smyth, T.; Temperton, B.
10.1101/2022.06.17.496560 — microbiology — Posted on 2022-06-17
1624 Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosis
Kendirli, A.; de la Rosa, C.; Laummle, K. F.; Eglseer, K. M.; Bauer, I. J.; Kavaka, V.; Winklmeier, S.; Wichmann, C.; Gerdes, L.-A.; Kuempfel, T.; Dornmair, K.; Beltran, E.; Kerschensteiner, M.; Kawakami, N.
10.1101/2022.06.17.496548 — immunology — Posted on 2022-06-17
1625 A comparison of methods to suppress electrocardiographic artifacts in local field potential recordings
Stam, M. J.; van Wijk, B. C. M.; Sharma, P.; Beudel, M.; Pina-Fuentes, D. A. I.; de Bie, R. M. A.; Schuurman, R. P. R.; Neumann, W.-J.; Buijink, A. W. G.
10.1101/2022.06.17.496567 — neuroscience — Posted on 2022-06-17
1627 Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control
Tousley, A. M.; Rotiroti, M. C.; Labanieh, L.; Rysavy, L. W.; Rietberg, S. P.; de la Serna, E. L.; Dalton, G. N.; Klysz, D.; Weber, E. W.; Kim, W.-J.; Xu, P.; Sotillo, E.; Dunn, A. R.; Mackall, C. L.; Majzner, R. G.
10.1101/2022.06.17.496457 — synthetic biology — Posted on 2022-06-17
1628 Lactose-based surfactants complexable with oligonucleic acids as gene delivery agents
Wilkowska, M.; Makrocka-Rydzyk, M.; Michocka, K.; Zielinski, R.; Sobczak, K.; Kozak, M.
10.1101/2022.06.17.496588 — biophysics — Posted on 2022-06-17
1629 COVFlow: virus phylodynamics analyses from selected SARS-CoV-2 sequences
Danesh, G.; Boennec, C.; Verdurme, L.; Roussel, M.; Trombert, S.; Visseaux, B.; Haim-Boukobza, S.; Alizon, S.
10.1101/2022.06.17.496544 — bioinformatics — Posted on 2022-06-17
1630 Bioinspired Silk Fibroin Mineralization for Advanced In Vitro Bone Remodeling Models
de Wildt, B. W. M.; van der Meijden, R.; Bartels, P. A. A.; Sommerdijk, N. A. J. M.; Akiva, A.; Ito, K.; Hofmann, S.
10.1101/2022.06.17.496534 — bioengineering — Posted on 2022-06-17
1632 Long non-coding RNA as environmental regulator in a non-model fish
Kang, J.; Chung, A.; Suresh, S.; Bonzi, L. C.; Sourisse, J. M.; Ramirez-Calero, S.; Romeo, D.; Petit-Marty, N.; Pegueroles, C.; Schunter, C.
10.1101/2022.06.17.496488 — molecular biology — Posted on 2022-06-17
1635 Group A Streptococcus Induces Lysosomal Dysfunction in THP-1 Macrophages
Nishioka, S. T.; Snipper, J.; Lee, J.; Schapiro, J.; Zhang, R. Z.; Abe, H.; Till, A.; Okumura, C. Y.
10.1101/2022.06.17.496523 — microbiology — Posted on 2022-06-17
1636 Bystander memory-phenotype conventional CD4+ T cells exacerbating autoimmune neuroinflammation
Choi, J.-M.; Cho, M.-Z.; Lee, H.-G.; Yoon, J.-W.; Kim, G.-R.; Koo, J.-H.; Taneja, R.; Edelson, B.; Lee, Y. J.
10.1101/2022.06.17.496529 — immunology — Posted on 2022-06-17
1637 MmCMS: Mouse models' Consensus Molecular Subtypes of colorectal cancer
Amirkhah, R.; Gilroy, K.; Malla, S.; Lannagan, T.; Byrne, R.; Fisher, N. C.; Corry, S.; Naderi-Meshkin, H.; Ahmaderaghi, B.; Murray, R.; Mills, M.; Campbell, A.; ACRCelerate consortium, ; Berenguer Llergo, A.; Sanz-Pamplona, R.; Villanueva, A.; Batlle, E.; Salazar, R.; Lawler, M.; Sansom, O. J.; Dunne, P.
10.1101/2022.06.17.496539 — cancer biology — Posted on 2022-06-17
1638 MIDAS2: Metagenomic Intra-species Diversity Analysis System
Zhao, C.; Dimitrov, B.; Goldman, M.; Nayfach, S.; Pollard, K. S.
10.1101/2022.06.16.496510 — bioinformatics — Posted on 2022-06-17
1639 Structural basis for activation of DNMT1
Onoda, H.; Kikuchi, A.; Yamaguchi, K.; Kori, S.; Matsuzawa, S.; Chiba, Y.; Tanimoto, S.; Yoshimi, S.; Sato, H.; Yamagata, A.; Shirouzu, M.; Adachi, N.; Sharif, J.; Koseki, H.; Nishiyama, A.; Nakanishi, M.; Defossez, P. A.; Arita, K.
10.1101/2022.06.16.496385 — biochemistry — Posted on 2022-06-17
1643 Forest fragmentation drives zoonotic malaria prevalence in non-human primate hosts
Johnson, E.; Sunil Kumar Sharma, R.; Ruiz Cuenca, P.; Byrne, I.; Salgado-Lynn, M.; Suraya Shahar, Z.; Col Lin, L.; Zulkifli, N.; Dilaila Mohd Saidi, N.; Drakeley, C.; Matthiopoulos, J.; Nelli, L.; Fornace, K.
10.1101/2022.06.17.496284 — ecology — Posted on 2022-06-17
1648 Alternative Splicing of Apoptosis Genes Promotes Human T Cell Survival
Blake, D.; Radens, C. M.; Ferretti, M. B.; Gazzara, M. R.; Lynch, K. W.
10.1101/2022.06.17.496561 — molecular biology — Posted on 2022-06-17
1649 Physiology and structure of pathogenic Escherichia coli pOmpT reveal two substrate-binding sites
Liu, J.; Ran, T.; Jiang, L.; Gao, Q.; Huan, C.; Wang, H.; Wang, W.; Gao, S.; Liu, X.
10.1101/2022.06.17.496525 — microbiology — Posted on 2022-06-17
1650 The meningeal transcriptional response to traumatic brain injury and aging
Bolte, A. C.; Shapiro, D. A.; Dutta, A. B.; Feng Ma, W.; Bruch, K. R.; Marco, A. R.; Lukens, J. R.
10.1101/2022.06.16.496485 — neuroscience — Posted on 2022-06-17
1651 Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy
Jafarian, A.; Hughes, L.; Adams, N. E.; Lanskey, J.; Naessens, M.; Rouse, M. A.; Murley, A. G.; Friston, K.; Rowe, J.
10.1101/2022.06.17.493881 — neuroscience — Posted on 2022-06-17
1652 The actin nucleator Spire cooperates with Rab11 to initiate nascent dendrite branches.
Hatton, D.; Marquilly, C.; Hanrahan, C.; Ferreira, T. A.; Ou, Y.; Silkworth, W.; Quinlan, M.; van Meyel, D. J.
10.1101/2022.06.16.496481 — neuroscience — Posted on 2022-06-17
1653 Multimodal single cell analysis of the paediatric lower airway reveals novel immune cell phenotypes in early life health and disease
Maksimovic, J.; Shanthikumar, S.; Howitt, G.; Hickey, P. F.; Ho, W.; Anttila, C.; Brown, D. V.; Senabouth, A.; Kaczorowski, D.; Amann-Zalcenstein, D.; Powell, J. E.; Ranganathan, S.; Oshlack, A.; Neeland, M. R.
10.1101/2022.06.17.496207 — systems biology — Posted on 2022-06-17
1656 Epigenetic reprogramming of melanoma cell state through fatty acid β-oxidation and Toll like receptor 4 signaling
Huang, T.-H.; Ma, Y.; Montal, E.; Suresh, S.; Tagore, M. M.; Corbin, A.; Lumaquin, D.; Campbell, N. R.; Baggiolini, A.; Koche, R. P.; White, R. M.
10.1101/2022.06.16.496450 — cancer biology — Posted on 2022-06-17
1657 Nuclear fascin regulates cancer cell survival
Lawson, C. D.; Peel, S.; Jayo, A.; Corrigan, A.; Iyer, P.; Baxter Dalrymple, M.; Marsh, R. J.; Cox, S.; Van Audenhove, I.; Gettemans, J.; Parsons, M.
10.1101/2022.06.17.496538 — cancer biology — Posted on 2022-06-17
1664 Epsin2, a novel target for multiple system atrophy therapy via regulating α-synuclein propagation associated with FABP7
Cheng, A.; Wang, Y.; Sekimori, T.; Jia, W.; Chen, Y.; Finkelstein, D. I.; Kawahata, I.; Sasaki, T.; Fukunaga, K.
10.1101/2022.06.16.496509 — pathology — Posted on 2022-06-17
1665 Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer
Zhu, Y.; Zhao, Y.; Wen, J.; Liu, S.; Huang, T.; Hatial, I.; Peng, X.; Janabi, H. A.; Huang, G.; Mittlesteadt, J.; Cheng, M.; Bhardwaj, A.; Ashfeld, B.; Kao, K. R.; Maeda, D. Y.; Dai, X.; Wiest, O.; Blagg, B.; Lu, X.; Cheng, L.; Wan, J.; Lu, X.
10.1101/2022.06.16.496505 — cancer biology — Posted on 2022-06-17
1666 The virtualome: a computational framework toevaluate microbiome analyses
Serrano-Anton, B.; Rodriguez-Ventura, F.; Colomer-Vidal, P.; Aiese Cigliano, R.; Arias, C. F.; Bertocchini, F.
10.1101/2022.06.16.496511 — bioinformatics — Posted on 2022-06-17
1667 Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns
Soerensen, S. G.; Shrikhande, A.; Poulsgaard, G. A.; Christensen, M. H.; Bertl, J.; Hoffmann, E. R.; Pedersen, J. S.
10.1101/2022.01.31.478445 — genomics — Posted on 2022-06-17
1669 Use of a citizen science tool for the determination of biological invasions in urban areas
Botan, A. L.; Heringer, G.; Matos, A. C.; Oliveira, D. L.; Ramos de Alvarenga, D.; Wilson de Almeida, J.; Palmieri Tavares, K.; Lopes Bueno, M.; Lopes, V. H.; Zenni, R.
10.1101/2022.06.16.496492 — ecology — Posted on 2022-06-17
1671 Fish environmental DNA in lake sediment overcomes the gap of reconstructing past fauna in lake ecosystems
Sakata, M. K.; Tsugeki, N.; Kuwae, M.; Ochi, N.; Hayami, K.; Osawa, R.; Morimoto, T.; Yasashimoto, T.; Takeshita, D.; Doi, H.; Minamoto, T.
10.1101/2022.06.16.496507 — ecology — Posted on 2022-06-17
1675 Calcineurin associates with centrosomes and regulates cilia length maintenance
Tsekitsidou, E.; Wang, J. T.; Wong, C. J.; Ulengin-Talkish, I.; Stearns, T.; Gingras, A.-C.; Cyert, M. S.
10.1101/2022.06.16.496489 — cell biology — Posted on 2022-06-17
1682 Quantitative mapping of synaptic periactive zone architecture and organization
Del Signore, S. J.; Mitzner, M. G.; Silveira, A. M.; Fai, T. G.; Rodal, A. A.
10.1101/2022.06.16.496425 — neuroscience — Posted on 2022-06-17
1683 Spatial tuning in nociceptive processing is driven by attention
Adamczyk, W. M.; Katra, M.; Szikszay, T.; Peugh, J.; King, C.; Luedtke, K.; Coghill, R. C.
10.1101/2022.06.16.496352 — neuroscience — Posted on 2022-06-17
1684 Depletion of FH, an essential TCA cycle enzyme, drives proliferation in a two-step model
Solaimuthu, B.; Lichtenstein, M.; Hayashi, A.; Khatib, A.; Plaschkes, I.; Nevo, Y.; Tanna, M.; Lavi, S.; Pines, O.; Shaul, Y. D.
10.1101/2022.06.16.496410 — cancer biology — Posted on 2022-06-17
1685 Engineered bacteria recruit and orchestrate anti-tumor immunity
Savage, T. M.; Vincent, R. L.; Rae, S. S.; Huang, L. H.; Ahn, A.; Pu, K.; Li, F.; Coker, C.; Danino, T.; Arpaia, N.
10.1101/2022.06.16.496462 — cancer biology — Posted on 2022-06-17
1686 Hepatocellular carcinoma hosts immature neurons and cholinergic tumors that correlate with adverse molecular features and outcomes
Hernandez, C. A.; Verzeroli, C.; Chicherova, I.; Farca-Luna, A.-J.; Tonon, L.; Bellaud, P.; Turlin, B.; Fautrel, A.; Macek-Jilkova, Z.; Decaens, T.; Rebouissou, S.; Viari, A.; Zoulim, F.; Parent, R.
10.1101/2022.06.14.495889 — cancer biology — Posted on 2022-06-17
1687 NADPH oxidase promotes glioblastoma radiation resistance in a PTEN-dependent manner
Ludwig, K.; Le Belle, J.; Muthukrishnan, S. D. D.; Sperry, J.; Condro, M.; Vlashi, E.; Pajonk, F.; Kornblum, H.
10.1101/2022.06.16.496502 — cancer biology — Posted on 2022-06-17
1688 Vitrocam: A simple low cost Vitrobot camera for assessing grid quality
Chua, E. Y. D.; Serbynovskyi, V.; Gheorghita, R.; Alink, L. M.; Podolsky, D.; Potter, C. S.; Carragher, B.
10.1101/2022.06.16.496351 — biophysics — Posted on 2022-06-17
1690 Generative Adversarial Networks Can Create High Quality Artificial Prostate Cancer Magnetic Resonance Images
Xu, I.; Van Booven, D.; Goberdhan, S.; Breto, A. L.; Alhusseini, M.; Algohary, A.; Stoyanova, R.; Mahne, A.; Punnen, S.; ARORA, H.
10.1101/2022.06.16.496437 — bioinformatics — Posted on 2022-06-17
1691 Revealing invisible cell phenotypes with conditional generative modeling
Lamiable, A.; Champetier, T.; Leonardi, F.; Cohen, E.; Sommer, P.; Hardy, D.; Argy, N.; Massougbodji, A.; Del Nery, E.; Cottrell, G.; Kwon, Y.-J.; Genovesio, A.
10.1101/2022.06.16.496413 — bioinformatics — Posted on 2022-06-17
1694 De novo design of site-specific protein interactions with learned surface fingerprints
Gainza, P.; Wehrle, S.; Van Hall-Beauvais, A.; Marchand, A.; Scheck, A.; Harteveld, Z.; Ni, D.; Tan, S.; Sverrisson, F.; Goverde, C.; Turelli, P.; Raclot, C.; Teslenko, A.; Pacesa, M.; Rosset, S.; Georgeon, S.; Marsden, J.; Petruzzella, A.; Liu, K.; Xu, Z.; Chai, Y.; Han, P.; Gao, G. F.; Oricchio, E.; Fierz, B.; Trono, D.; Stahlberg, H.; Bronstein, M.; Correia, B. E.
10.1101/2022.06.16.496402 — bioengineering — Posted on 2022-06-17
1695 Schedule-dependent production of stereotyped sequences of actions
Follman, E. G.; Chevee, M.; Kim, C. J.; Johnson, A. R.; Tat, J.; Calipari, E. S.
10.1101/2022.06.16.496442 — animal behavior and cognition — Posted on 2022-06-17
1698 Fancm regulates meiotic double-strand break repair pathway choice in mammals
Tsui, V.; Lyu, R.; Novakovic, S.; Stringer, J. M.; Dunleavy, J. E. M.; Granger, E.; Semple, T.; Leitchter, A.; Martelotto, L.; Merriner, D. J.; Liu, R.; McNeill, L.; Zerafa, N.; Hoffmann, E.; O'Bryan, M. K.; Hutt, K.; Deans, A. J.; Heierhorst, J.; McCarthy, D. J.; Crismani, W.
10.1101/2022.06.16.496499 — genetics — Posted on 2022-06-17
1701 cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning
Wang, X.; Zhou, L.; Xu, F.-X.; Wang, D.-J.; Cai, X.-Y.; Wang, Y.; Ji, S.-J.; Schonewille, M.; Zhu, J. J.; De Zeeuw, C. I.; Shen, Y.
10.1101/2022.06.15.496308 — neuroscience — Posted on 2022-06-17
1706 AuCoMe: inferring and comparing metabolisms across heterogeneous sets of annotated genomes
Belcour, A.; Got, J.; Aite, M.; Delage, L.; Collen, J.; Frioux, C.; Leblanc, C.; Dittami, S. M.; Blanquart, S.; Markov, G.; Siegel, A.
10.1101/2022.06.14.496215 — systems biology — Posted on 2022-06-17
1708 Oligomerisation of a plant helper NLR requires cell-surface and intracellular immune receptor activation
Feehan, J. M.; Wang, J.; Sun, X.; Choi, J.; Ahn, H.-K.; Ngou, B. P. M.; Parker, J. E.; Jones, J. D.
10.1101/2022.06.16.496440 — plant biology — Posted on 2022-06-17
1709 17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice
Ali Mondal, S.; Sathiaseelan, R.; Mann, S.; Kamal, M.; Luo, W.; Saccon, T.; Isola, J.; Peeler, R.; Li, T.; Freeman, W. M.; Miller, B.; Stout, M.
10.1101/2022.06.16.496423 — physiology — Posted on 2022-06-17
1710 Blocking mitochondrial alanine and pyruvate metabolism in hepatocytes worsens acetaminophen-induced liver injury in mice
Vazquez, J. H.; Yiew, N. K.; Martino, M. R.; Allard, F. D.; Yee, E. U.; McCullough, S. S.; James, L. P.; Finck, B. N.; McGill, M. R.
10.1101/2022.06.14.495517 — pharmacology and toxicology — Posted on 2022-06-17
1712 Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer
Kandala, S.; Voith von Voithenberg, L.; Chocarro, S.; Ramos, M.; Keding, J.; Brors, B.; Imbusch, C.; Sotillo, R.
10.1101/2022.06.16.496429 — cancer biology — Posted on 2022-06-17
1714 Hybrid Autoencoder with Orthogonal Latent Space for Robust Population Structure Inference
Yuan, M.; Hoskens, H.; Goovaerts, S.; Herrick, N.; Shriver, M. D.; Walsh, S.; Claes, P.
10.1101/2022.06.16.496401 — bioinformatics — Posted on 2022-06-17
1717 Isolation-by-distance and population-size history inferences from the coho salmon (Oncorhynchus kisutch) genome
Rondeau, E. B.; Christensen, K. A.; Minkley, D. R.; Leong, J. S.; Chan, M. T. T.; Despins, C. A.; Mueller, A.; Sakhrani, D.; Biagi, C. A.; Rougemont, Q.; Normandeau, E.; Jones, S. J. M.; Devlin, R. H.; Withler, R. E.; Beacham, T. D.; Naish, K. A.; Yanez, J. M.; Neira, R.; Bernatchez, L.; Davidson, W. S.; Koop, B. F.
10.1101/2022.06.14.496192 — genomics — Posted on 2022-06-17
1719 Draft genome of the lowland anoa (Bubalus depressicornis) and comparison with buffalo genome assemblies (Bovidae, Bubalina)
Porrelli, S.; Gerbault-Seureau, M.; Rozzi, R.; Chikhi, R.; Curaudeau, M.; Ropiquet, A.; Hassanin, A.
10.1101/2022.06.14.496191 — genomics — Posted on 2022-06-17
1726 PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM
Frenster, J. D.; Erdjument-Bromage, H.; Liu, W.; Stephan, G.; Ravn-Boess, N.; Bready, D.; Wilcox, J.; Kieslich, B.; Jankovic, M.; Wilde, C.; Horn, S.; Straeter, N.; Liebscher, I.; Schoneberg, T.; Fenyö, D.; Neubert, T. A.; Placantonakis, D. G.
10.1101/2022.06.15.496232 — cell biology — Posted on 2022-06-17
1727 An S1 subunit vaccine and combination adjuvant (COVAC-1) elicits robust protection against SARS-CoV-2 challenge in African green monkeys
Garnett, L.; Tran, K.; Chan, M.; Tierney, K.; Schiffman, Z.; Audet, J.; Lew, J.; Meilleur, C.; Chan, M.; Manguiat, K.; Tailor, N.; Vendramelli, R.; Deschambault, Y.; Beaudoin-Bussieres, G.; Bourassa, C.; Richard, J.; Finzi, A.; Higgins, R.; van den Hurk, S.; Gerdts, V.; Strong, J.; Falzarano, D.
10.1101/2022.06.16.496375 — microbiology — Posted on 2022-06-17
1728 Phytochemical and antibacterial analyses of Onychium japonicum (Thunb.) Kunze.
Shah, S. A.; Shah, G. M.; Hassan, M. M.; Alsanie, W. F.; Nawazish, S.; Ali, W.; Basit, A.; Shafqath, D. N.; Jabeen, N.; Shah, S. A. M.; Shah, Z.; Ishtiaq, M.; GUL, D. A.; alam, j.; ISLAM, M.; Faheem, A.; Experts from Microbiology and Biichemistry as well participated in the current work,
10.1101/2022.06.14.496165 — microbiology — Posted on 2022-06-17
1729 Segmental flexibility of bispecific T-cell engagers regulates the dynamics of immune synapse formation
Staufer, O.; Leithner, A.; Zhou, S.; Crames, M.; Comeau, S.; Young, D.; Low, S.; Jenkins, E.; Davis, S. J.; Nixon, A.; Pefaur, N.; Kasturirangan, S.; Dustin, M. L.
10.1101/2022.06.15.496334 — immunology — Posted on 2022-06-17
1730 Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity
Grajchen, E.; Loix, M.; Baeten, P.; Cortereal, B.; Hamad, I.; Haidar, M.; Dehairs, J.; Broos, J.; Ntambi, J.; Zimmermann, R.; Breinbauer, R.; Stinissen, P.; Hellings, N.; Kooij, G.; Giera, M.; Swinnen, J. V.; Broux, B.; Kleinewietfeld, M.; Hendriks, J. J. A.; Bogie, J. F. J.
10.1101/2022.06.16.496386 — immunology — Posted on 2022-06-17
1731 Vulnerable Brain Networks Associated with Risk for Alzheimer's Disease
Mahzarnia, A.; Stout, J. A.; Anderson, R. J.; Moon, H. S.; Han, Z. Y.; Beck, K.; Browndyke, J. N.; Dunson, D. B.; Johnson, K. G.; O'Brien, R. J.; Badea, A.
10.1101/2022.06.15.496331 — neuroscience — Posted on 2022-06-17
1733 A multivariate brain signature for reward
Speer, S. P. H.; Keysers, C.; Smidts, A.; Boksem, M. A. S.; Wager, T. D.; Gazzola, V.
10.1101/2022.06.16.496388 — neuroscience — Posted on 2022-06-17
1734 Brain-Controlled Electrical Stimulation Restores Continuous Finger Function
Nason-Tomaszewski, S. R.; Mender, M. J.; Kennedy, E.; Lambrecht, J. M.; Kilgore, K. L.; Chiravuri, S.; Ganesh Kumar, N.; Kung, T. A.; Willsey, M. S.; Chestek, C. A.; Patil, P. G.
10.1101/2022.06.15.496349 — neuroscience — Posted on 2022-06-17
1738 An affinity for brainstem microglia in pediatric high grade gliomas of brainstem origin
Peretz Zats, L.; Ahmad, L.; Casden, N.; Lee, M. J.; Belzer, V.; Adato, O.; Bar-Cohen, S.; Ko, S.-H. B.; Filbin, M. G.; Unger, R.; Lauffenburger, D. A.; Segal, R.; Behar, O.
10.1101/2022.06.15.496357 — cancer biology — Posted on 2022-06-17
1742 Inferring CTCF insulators and anchored loops across human tissues and cell types
Xu, H.; Yi, X.; Wang, W.; Chu, X.; Huang, D.; Zhang, S.; Dong, X.; Wang, Z.; Wang, J.; Zhou, Y.; Zhao, K.; Yao, H.; Wang, J.; Chen, K.; Plewczynski, D.; Sham, P. C.; Li, M. J.
10.1101/2022.06.15.496356 — bioinformatics — Posted on 2022-06-17
1744 Opto-MASS: a high-throughput engineering platform for genetically encoded fluorescentsensors enabling all optical in vivo detection of monoamines and neuropeptides
Rappleye, M.; Gordon-Fennel, A.; Castro, D. C.; Matarasso, A. K.; Zamorano, C. A.; Stine, C.; Wait, S. J.; Lee, J. D.; Siebart, J. D.; Suko, A.; Smith, N. C.; Muster, J.; Matreyek, K. A.; Fowler, D. M.; Stuber, G. D.; Bruchas, M. R.; Berndt, A.
10.1101/2022.06.01.494241 — bioengineering — Posted on 2022-06-17
1745 A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides
Zhang, L.; Wang, Y.; Chen, P.; Wang, D.; Zhang, Z.; Ruimeng, W.; Kang, X.; Fang, Y.; Lu, H.; Cai, J.; Ren, M.; Dong, S.; Zhang, K.
10.1101/2022.06.15.496353 — bioengineering — Posted on 2022-06-17
1755 Phosphoprotein Phosphatase Activity Positively Regulates Oligomeric Pyrin to Trigger Inflammasome Assembly in Phagocytes
Malek, H. S.; Magnotti, F.; Loeven, N. A.; Delgado, J. M.; Kettenbach, A. N.; Henry, T.; Bliska, J. B.
10.1101/2022.03.23.485108 — immunology — Posted on 2022-06-17
1758 Synaptic Location Is a Determinant of the Detrimental Effects of alpha-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Chen, L.; Nagaraja, C.; Daniels, S.; Fisk, Z. A.; Dvorak, R.; Meyerdirk, L.; Steiner, J. A.; Galvis, M. L. E.; Henderson, M.; Rousseaux, M.; Brundin, P.; Chu, H.-y.
10.1101/2022.02.20.481207 — neuroscience — Posted on 2022-06-17
1759 Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat
Wittern, L. M.; Barrero, J. M.; Bovill, W. D.; Verbyla, K. L.; Hughes, T.; Swain, S. M.; Steed, G.; Webb, A. A.; Gardner, K.; Greenland, A.; Jacobs, J.; Frohberg, C.; Schmidt, R.-C.; Cavanagh, C.; Rohde, A.; Davey, M.; Hannah, M. A.
10.1101/2022.04.01.486512 — plant biology — Posted on 2022-06-17
1761 Pharmacological activation of the mitochondrial stress protease OMA1 reveals a therapeutic liability in Diffuse Large B-Cell Lymphoma
Schwarzer, A.; Oliveira, M.; Kleppa, M.-J.; Slattery, S. D.; Anantha, A.; Cooper, A.; Hannink, M.; Schambach, A.; Dorrie, A.; Kotlyarov, A.; Gaestel, M.; Hembrough, T.; Levine, J.; Luther, M.; Stocum, M.; Stiles, L.; Liesa, M.; Kostura, M. J.
10.1101/2022.06.12.495213 — cancer biology — Posted on 2022-06-17
1763 Single-molecule analysis of the entire perfringolysin O poreformation pathway
Mc Guinness, C.; Walsh, J.; Bayly-Jones, C.; Dunstone, M.; Morton, C.; Christie, M.; Parker, M. W.; Boecking, T.
10.1101/2021.10.19.464937 — biophysics — Posted on 2022-06-17
1768 The Interpretation of Computational Model Parameters Depends on the Context
Eckstein, M. K.; Master, S. L.; Xia, L.; Dahl, R. E.; Wilbrecht, L.; Collins, A. G. E.
10.1101/2021.05.28.446162 — neuroscience — Posted on 2022-06-17
1770 Using synthetic MR images for field map-less distortion correction
Montez, D. F.; Van, A. N.; Miller, R. L.; Seider, N. A.; Marek, S.; Zheng, A.; Newbold, D. J.; Scheidter, K.; Feczko, E.; Perrone, A. J.; Miranda Dominguez, O.; Earl, E. A.; Kay, B. P.; Jha, A. K.; Sotiras, A.; Laumann, T. O.; Greene, D. J.; Gordon, E. M.; Tisdall, M. D.; van der Kouwe, A.; Fair, D. A.; Dosenbach, N. U. F.
10.1101/2021.03.13.435270 — neuroscience — Posted on 2022-06-17
1771 First record of monogenean fish parasites in the Upper Lufira basin (Democratic Republic of Congo): dactylogyrids and gyrodactylids infecting Oreochromis mweruensis, Coptodon rendalli and Serranochromis macrocephalus (Teleostei: Cichlidae)
Kasembele, G. K.; Manda, A. C.; Abwe, E.; Pariselle, A.; Bukinga, F. M.; Huyse, T.; Jorissen, M. W. P.; Vreven, E. J.; Luus-Powell, W. J.; Smit, W.; Sara, J. R.; Snoeks, J.; Vanhove, M. P. M.
10.1101/2022.06.15.496317 — zoology — Posted on 2022-06-17
1773 GAMBIT (Genomic Approximation Method for Bacterial Identification and Tracking): A methodology to rapidly leverage whole genome sequencing of bacterial isolates for clinical identification
Lumpe, J.; Gumbleton, L.; Gorzalski, A.; Libuit, K.; Varghese, V.; Lloyd, T.; Tadros, F.; Arsimendi, T.; Wagner, E.; Stephens, C.; Sevinsky, J.; Hess, D.; PANDORI, M.
10.1101/2022.06.14.496173 — bioinformatics — Posted on 2022-06-17
1780 AKT1-FOXO4 AXIS REGULATES HEMOCHORIAL PLACENTATION
Kozai, K.; Moreno Irusta, A.; Iqbal, K.; Winchester, M.-L.; Scott, R. L.; Simon, M. E.; Muto, M.; Parrish, M. R.; Soares, M. J.
10.1101/2022.06.15.496110 — developmental biology — Posted on 2022-06-17
1781 CITED2 Is A Conserved Regulator Of Deep Hemochorial Placentation
Kuna, M.; Dhakal, P.; Iqbal, K.; Dominguez, E. M.; Kent, L. N.; Muto, M.; Moreno-Irusta, A.; Kozai, K.; Varberg, K. M.; Okae, H.; Arima, T.; Sucov, H. M.; Soares, M. J.
10.1101/2022.06.15.496287 — developmental biology — Posted on 2022-06-17
1784 Validation of a new coil array tailored for dog functional magnetic resonance imaging (fMRI) studies
Guran, C.- N. A.; Sladky, R.; Karl, S.; Boch, M.; Laistler, E.; Windischberger, C.; Huber, L.; Lamm, C.
10.1101/2022.06.14.496064 — neuroscience — Posted on 2022-06-17
1786 Integrated Proteomics Identifies Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease
Hurst, C. D.; Pugh, D. A.; Abreha, M. H.; Duong, D. M.; Dammer, E. B.; Bennett, D. A.; Herskowitz, J. H.; Seyfried, N. T.
10.1101/2022.06.15.496285 — neuroscience — Posted on 2022-06-17
1787 Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex
Wilson, M.; Thunemann, M.; Liu, X.; Lu, Y.; Puppo, F.; Adams, J.; Kim, J.-H.; Pizzo, D.; Djurovic, S.; Andreassen, O.; Mansour, A.; Gage, F. H.; Muotri, A. R.; Devor, A.; Kuzum, D.
10.1101/2022.06.16.496469 — neuroscience — Posted on 2022-06-17
1788 Visuo-motor transformations in the intraparietal sulcus mediate the acquisition of endovascular medical skill
Paul, K.; Mueller, K.; Rousseau, P.-N.; Glathe, A.; Taatgen, N. A.; Cnossen, F.; Lanzer, P.; Villringer, A.; Steele, C. J.
10.1101/2022.06.15.496236 — neuroscience — Posted on 2022-06-17
1789 Restoring synapse integrity and memory in Alzheimer's disease by downregulation of the Wnt antagonist Dickkopf-3
Martin-Flores, N.; Podpolny, M.; McLeod, F.; Crawford, K.; Ivanov, D.; Escott-Price, V.; Salinas, P. C.
10.1101/2022.06.16.495307 — neuroscience — Posted on 2022-06-17
1791 Dermal nerve growth factor is increased in prurigo nodularis compared to atopic dermatitis
Deng, J.; Parthasarathy, V.; Bordeaux, Z.; Marani, M.; Lee, K.; Trinh, C.; Sutaria, N.; Cornman, H.; Kambala, A.; Pritchard, T.; Chen, S.; Oladipo, O. O.; Kwatra, M. M.; Alphonse, M. A.; Kwatra, S. G.
10.1101/2022.06.15.496275 — pathology — Posted on 2022-06-17
1792 Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer
Ritchie, M.; Silberberg, G.; Walling, B.; Wesa, A.; Audia, A.; Sloma, I.; Zeng, Y.; Han, G.; Tabg, J.; Pammer, P.; Bakayoko, A.; Ciznadija, D.; Vishwakarma, B.; Mosesson, Y.; Zipeto, M.
10.1101/2022.06.14.495846 — cancer biology — Posted on 2022-06-17
1795 Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients.
Tarullo, S. E.; He, Y.; Daughters, C.; Knutson, T. P.; Henzler, C.; Price, M.; Shanley, R.; Witschen, P.; Tolg, C.; Kaspar, R. E.; Hallstrom, C.; Gittsovich, L.; Sulciner, M. L.; Zhang, X.; Forester, C.; Shats, O.; Desler, M. M.; Cowan, K.; Yee, D.; Schwertfeger, K. L.; Turley, E.; McCarthy, J. B.; Nelson, A. C.
10.1101/2022.06.13.495375 — cancer biology — Posted on 2022-06-17
1796 Inhibition of Fas Receptor Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis
Kural, M.; Djakbarova, U.; Cakir, B.; Tanaka, Y.; Madraki, Y.; Qian, H.; Park, J.; Sewanan, L.; Kural, C.; Niklason, L.
10.1101/2022.06.14.496195 — cancer biology — Posted on 2022-06-17
1798 Analyzing single-cell bisulfite sequencing data with scbs
Kremer, L. P.; Kuechenhoff, L.; Cerrizuela, S.; Martin-Villalba, A.; Anders, S.
10.1101/2022.06.15.496318 — bioinformatics — Posted on 2022-06-17
1799 The Impact of Storage Condition and Duration on Function of Native and Cargo-Loaded Mesenchymal Stromal Cell Extracellular Vesicles
Levy, D.; Jeyaram, A.; Born, L. J.; Chang, K.-H.; Nourmohammadi Abadchi, S.; Ting Wei Hsu, A.; Solomon, T.; Aranda, A.; Stewart, S.; He, X.; Harmon, J. W.; Jay, S. M.
10.1101/2022.06.14.496108 — bioengineering — Posted on 2022-06-17
1801 Evolving copy number gains promote tumor expansion and bolster mutational diversification
Wang, Z.; Xia, Y.; Mills, L. T.; Nikolakopoulos, A. N.; Maeser, N.; Sheltzer, J. M.; Sun, R.
10.1101/2022.06.14.495959 — genomics — Posted on 2022-06-17
1803 A pangenome analysis pipeline (PSVCP) provides insights into rice functional gene identification
Wang, J.; Wu, Y.; Zhang, S.; Hu, H.; Yuan, Y.; Dong, J.; Chen, L.; Ma, Y.; Yang, T.; Zhou, L.; Chen, J.; Liu, B.; Li, C.; Edwards, D.; Zhao, J.
10.1101/2022.06.15.496234 — genetics — Posted on 2022-06-17
1805 The development of intracytoplasmic membranes in alphaproteobacteria involves the conserved mitochondrial crista-developing Mic60 protein
Munoz-Gomez, S. A.; Cadena, L. R.; Gardiner, A. T.; Leger, M. M.; Sheikh, S.; Connell, L.; Bily, T.; Kopejtka, K.; Beatty, J. T.; Koblizek, M.; Roger, A. J.; Slamovits, C. H.; Lukes, J.; Hashimi, H.
10.1101/2022.06.14.496148 — evolutionary biology — Posted on 2022-06-17
1806 Statistical Population Reconstruction of Moose (Alces alces) in Northeastern Minnesota using Integrated Population Models
Severud, W. J.; Berg, S. S.; Ernst, C. A.; DelGiudice, G. D.; Moore, S. A.; Windels, S. K.; Moen, R. A.; Isaac, E. J.; Wolf, T. M.
10.1101/2022.06.15.496269 — ecology — Posted on 2022-06-17
1807 Temperature impacts on dengue incidence are nonlinear and mediated by climatic and socioeconomic factors
Kirk, D.; Straus, S.; Childs, M.; Harris, M.; Couper, L.; Davies, J.; Forbes, C.; Gehman, A.-L.; Groner, M.; Harley, C.; Lafferty, K.; Savage, V.; Skinner, E.; O'Connor, M. I.; Mordecai, E. A.
10.1101/2022.06.15.496305 — ecology — Posted on 2022-06-17
1808 Sampling strategies and pre-pandemic surveillance gaps for bat coronaviruses
Cohen, L. E.; Fagre, A. C.; Chen, B.; Carlson, C. J.; Becker, D. J.
10.1101/2022.06.15.496296 — ecology — Posted on 2022-06-17
1809 Hox11-expressing interstitial cells contribute to adult skeletal muscle at homeostasis
Flynn, C. G. K.; Guo, Q.; Van Ginkel, P. R.; Hrycaj, S. M.; McDermott, A. E.; Madruga, A.; Wellik, D. M.
10.1101/2022.06.14.496124 — developmental biology — Posted on 2022-06-17
1810 Conservation at the uterine-placental interface
Scott, R. L.; Vu, H. T. H.; Jain, A.; Iqbal, K.; Tuteja, G.; Soares, M. J.
10.1101/2022.06.14.496152 — developmental biology — Posted on 2022-06-17
1812 Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
Preger, C.; Notarnicola, A.; Hellstrom, C.; Wigren, E.; Fernandes-Cerqueira, C.; Idborg, H.; Lundberg, I. E.; Persson, H.; Graslund, S.; Jakobsson, P.-J.
10.1101/2022.06.13.495951 — immunology — Posted on 2022-06-17
1814 The AI Neuropsychologist: Automatic scoring of memory deficits with deep learning
Langer, N.; Weber, M.; Hebling Vieira, B.; Strzelczyk, D.; Wolf, L.; Pedroni, A.; Heitz, J.; Schultheis, C.; Troendle, M.; Arango Lasprilla, J. C.; Rivera, D.; Scarpina, F.; Zhao, Q.; Leuthold, R.; Wehrle, F.; Jenni, O. G.; Brugger, P.; Zaehle, T.; Lorenz, R.; Zhang, C.
10.1101/2022.06.15.496291 — neuroscience — Posted on 2022-06-17
1816 Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimers Disease
Henkel, N. D.; Joyce, A.; Shedroff, E.; Imami, A. S.; Alganem, K.; Hamoud, A.-r.; Xu, C.; Siciliano, B.; Ma, T.; Wen, Z.; McCullumsmith, R. E.
10.1101/2022.06.14.496149 — neuroscience — Posted on 2022-06-17
1818 Axo-vascular coupling mediated by oligodendrocytes
Restrepo, A.; Trevisiol, A.; Restrepo-Arango, C.; Depp, C.; Sasmita, A. O.; Keller, A.; Tzvetanova, I. D.; Hirrlinger, J.; Nave, K.-A.
10.1101/2022.06.16.495900 — neuroscience — Posted on 2022-06-17
1819 Candesartan treatment preserves learning and working memory in female TgF344-AD rats
Sinon, C. G.; Carter, K.; Ma, J.; Bagchi, P.; Zhang, X.; Williams, P.-J. C.; Dammer, E. B.; Seyfried, N. T.; Garcia, P. S.; Sutliff, R. L.; Hajjar, I.
10.1101/2022.06.14.496112 — neuroscience — Posted on 2022-06-17
1820 Measuring brain critical dynamics to inform Brain-Computer Interfaces
Corsi, M.-C.; Sorrentino, P.; Schwartz, D.; George, N.; Hugueville, L.; Kahn, A. E.; Dupont, S.; Bassett, D. S.; Jirsa, V.; De Vico Fallani, F.
10.1101/2022.06.14.495887 — neuroscience — Posted on 2022-06-17
1822 A robust intensity distribution alignment for harmonization of T1w intensity values
Sederevicius, D.; Bjornerud, A.; Walhovd, K. B.; Leemput, K. V.; Fischl, B.; Fjell, A. M.
10.1101/2022.06.15.496227 — neuroscience — Posted on 2022-06-17
1829 Dietary polyphenols drive alterations in behavior, transcriptional regulation, and commensal microbiota in models of opioid use.
Osman, A.; Hofford, R. S.; Meckel, K. R.; Dave, Y. A.; Zeldin, S. M.; Shipman, A. L.; Lucerne, K. E.; Trageser, K. J.; Oguchi, T.; Pasinetti, G. M.; Kiraly, D. D.
10.1101/2022.06.14.496180 — neuroscience — Posted on 2022-06-17
1833 Disrupting cellular memory to overcome drug resistance
Harmange, G.; Reyes Hueros, R. A.; Schaff, D. L.; Emert, B. L.; Saint-Antoine, M. M.; Nellore, S.; Fane, M. E.; Alicea, G. M.; Weeraratna, A. T.; Singh, A.; Shaffer, S. M.
10.1101/2022.06.16.496161 — systems biology — Posted on 2022-06-17
1835 SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell
Iida, H.; Kono, T. M.; Lee, C.-C.; Krishnan, P.; Arvin, M. C.; Weaver, S. A.; Jarvela, T. S.; Bone, R. N.; Tong, X.; Arvan, P.; Lindberg, I.; Evans-Molina, C.
10.1101/2022.06.13.495980 — physiology — Posted on 2022-06-17
1836 Increased severity of chronic kidney disease in response to high potassium intake is dependent on mineralocorticoid receptor activation
Olivier, V.; Arnoux, G.; Ramakrishnan, S.; SASSI, A.; Roth, I.; Chassot, A.; Tournier, M.; Dizin, E.; Hummler, E.; Rutkowski, J.; Feraille, E.
10.1101/2022.06.15.496280 — physiology — Posted on 2022-06-17
1837 Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential
Harrington, S.; Pyche, J.; Burns, A. R.; Spalholz, T.; Baker, R. J.; Ching, J.; Lautens, M.; Kulke, D.; Deuther-Conrad, W.; Brust, P.; Roy, P. J.
10.1101/2022.06.14.496146 — pharmacology and toxicology — Posted on 2022-06-17
1840 Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy
Niaudet, C.; Jung, B.; Kuo, A.; Swendeman, S.; Bull, E.; Seno, T.; Crocker, R.; Fu, Z.; Smith, L. E. H.; Hla, T.
10.1101/2022.06.14.496172 — pathology — Posted on 2022-06-17
1841 The differential metabolic signature of breast cancer cellular response to olaparib treatment
Berardi, D.; Hunter, Y.; van den Driest, L.; Farrell, G.; Rattray, N. J.; Rattray, Z.
10.1101/2022.06.14.495928 — cancer biology — Posted on 2022-06-16
1843 Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles
Ragusa, D.; Ciciro, Y.; Federico, C.; Saccone, S.; Bruno, F.; Saeedi, R.; Sisu, C.; Pina, C.; Sala, A.; Tosi, S.
10.1101/2022.06.14.496084 — cancer biology — Posted on 2022-06-17
1844 Targeting H3K4 methylation as a novel therapeutic strategy against tumor infiltration and nuclear changes of acute lymphoblastic leukemia cells.
Gonzalez-Novo, R.; De Lope, A.; Gonzalez-Murillo, A.; Madrazo, E.; Acitores, D.; Garcia de Lacoba, M.; Ramirez, M.; Redondo-Munoz, J.
10.1101/2022.06.16.495903 — cancer biology — Posted on 2022-06-17
1845 The G-protein-coupled estrogen receptor, a gene co-expressed with ERα in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cells.
Pal, U.; Manjegowda, M. C.; Singh, N.; Saikia, S.; Philip, B. S.; Kalita, D. J.; Rai, A. K.; Sarma, A.; Raphael, V.; Modi, D.; Kataki, A. C.; Limaye, A. M.
10.1101/2022.06.14.496079 — cancer biology — Posted on 2022-06-17
1847 In BRAFV600E-mutated colorectal cancer cells, fascin1 restructures adherens junctions to drive Wnt activation
Pham, E.; Esmaeilniakooshkghazi, A.; George, S. P.; Ahrorov, A.; Villagomez, F. R.; Byington, M.; Mukhopadhyay, S.; Patnaik, S.; Conrad, J. C.; Naik, M.; Ravi, S.; Tebbuttt, N.; Mooi, J.; Reehorst, C. M.; Mariadason, J. M.; Khurana, S.
10.1101/2022.06.14.496198 — cancer biology — Posted on 2022-06-17
1853 GADMA2: more efficient and flexible demographic inference from genetic data
Noskova, E.; Abramov, N.; Iliutkin, S.; Sidorin, A.; Dobrynin, P.; Ulyantsev, V.
10.1101/2022.06.14.496083 — bioinformatics — Posted on 2022-06-17
1856 Uncertainty quantification of reference based cellular deconvolution algorithms
Seiler Vellame, D.; Shireby, G.; MacCalman, A.; Dempster, E. L.; Burrage, J.; Gorrie-Stone, T.; Schalkwyk, L. S.; Mill, J.; Hannon, E.
10.1101/2022.06.15.496235 — bioinformatics — Posted on 2022-06-17
1858 Condition-Specific Mapping of Operons (COSMO) using dynamic and static genome data
Calvert-Joshua, T.; Bendou, H.; van Heusden, P.; Grobbelaar, M.; Warren, R.; Christoffels, A.
10.1101/2022.06.14.496048 — bioinformatics — Posted on 2022-06-17
1860 Improving de novo Protein Binder Design with Deep Learning
Bennett, N.; Coventry, B.; Goreshnik, I.; Huang, B.; Allen, A.; Vafeados, D.; Peng, Y. P.; Dauparas, J.; Baek, M.; Stewart, L.; DiMaio, F.; De Munck, S.; Savvides, S.; Baker, D.
10.1101/2022.06.15.495993 — bioengineering — Posted on 2022-06-17
1862 Decoding Imagined Musical Pitch from Human Scalp Electroencephalograms
Chung, M.; Kim, T.; Jeong, E.; Chung, C.-K.; Kim, J.-S.; Kwon, O.-S.; Kim, S.-P.
10.1101/2022.06.13.495849 — bioengineering — Posted on 2022-06-17
1866 Stable twin rDNA loci form a single nucleolus in brewer's yeast
Stefanita, L. L.; Boeke, J.; Luo, J.; Haase, M. A. B.; Zhang, W.
10.1101/2022.06.14.496147 — genomics — Posted on 2022-06-16
1867 PlantCADB: A comprehensive plant chromatin accessibility database
ding, k.; sun, s.; long, c.; luo, y.; zhai, j.; zhai, y.; wang, g.
10.1101/2022.06.15.496248 — genomics — Posted on 2022-06-17
1869 Endothelial TET2 Regulates Cardiac Remodeling by Modifying Endothelial-to-Mesenchymal Transition
Kou, W.; Shi, Y.; Li, B.; Zeng, Y.; Zhai, M.; You, S.; Yu, Q.; Gong, S.-y.; Zhuang, J.; Zhao, Y.; Xia, J.; Xu, Y.-W.; Peng, W.
10.1101/2022.06.15.496224 — genetics — Posted on 2022-06-16
1871 The formation of the Indo-Pacific montane avifauna
Reeve, A. H.; Kennedy, J. D.; Pujolar, J. M.; Petersen, B.; Blom, M. P. K.; Alström, P.; Haryoko, T.; Ericson, P. G. P.; Irestedt, M.; Nylander, J. A. A.; Jonsson, K. A.
10.1101/2022.06.15.495085 — evolutionary biology — Posted on 2022-06-16
1872 Rapid compensatory evolution by secondary perturbation of a primary disrupted transcriptional network
Hsu, P.-C.; Cheng, Y.-H.; Liao, C.-W.; Jhou, Y.-T.; Opoc, F. J. G.; Amine, A. A. A.; Leu, J.-Y.
10.1101/2022.06.15.496250 — evolutionary biology — Posted on 2022-06-16
1874 Poison frog diet and chemical defense are influenced by availability and selectivity for ants
Moskowitz, N. A.; Alvarez-Buylla, A.; Morrison, C. R.; Chamba, A.; Renteria, J.; Tapia, E. E.; Coloma, L. A.; Donoso, D. A.; O'Connell, L. A.
10.1101/2022.06.14.495949 — ecology — Posted on 2022-06-16
1876 Estimating the cumulative impact and zone of influence of anthropogenic infrastructure on biodiversity
Niebuhr, B. B.; van Moorter, B.; Stien, A.; Tveraa, T.; Strand, O.; Langeland, K.; Sandström, P.; Alam, M.; Skarin, A.; Panzacchi, M.
10.1101/2022.06.14.495994 — ecology — Posted on 2022-06-16
1877 The application of neural networks to classify dolphin echolocation clicks
Seydi, V.; Chapuis, L.; Veneruso, G.; Balaguru, S.; Bristow, N.; Mills, D.; Le Vay, L.
10.1101/2022.06.14.496047 — ecology — Posted on 2022-06-16
1878 VALPROIC ACID AFFECTS NEURONAL SPECIFICATION AND DIFFERENTIATION DURING EARLY OPTIC TECTUM DEVELOPMENT OF ZEBRAFISH
Dixon, S. C.; Calder, B. J.; Lilya, S. M.; Davies, B. M.; Martin, A.; Peterson, M.; Hansen, J.; Suli, A.
10.1101/2022.06.15.496299 — developmental biology — Posted on 2022-06-16
1881 Hnf1b renal expression directed by a distal enhancer responsive to Pax8
Goea, L.; Buisson, I.; Bello, V.; Eschstruth, A.; Paces-Fessy, M.; Le Bouffant, R.; Chesneau, A.; Cereghini, S.; Riou, J.-F.; Umbhauer, M.
10.1101/2022.06.14.496053 — developmental biology — Posted on 2022-06-17
1889 Gray matter cortical thickness predicts individual pain sensitivity: a multi-center machine learning approach
Kotikalapudi, R.; Kincses, B.; Zunhammer, M.; Schlitt, F.; Schmidt-Wilcke, T.; Kincses, Z. T.; Asan, L.; Bingel, U.; Spisak, T.
10.1101/2022.06.14.496092 — neuroscience — Posted on 2022-06-16
1893 Subventricular zone cytogenesis provides trophic support for neural repair
Williamson, M. R.; Le, S. P.; Franzen, R. L.; Donlan, N. A.; Rosow, J. L.; Dunn, A. K.; Jones, T.; Drew, M. R.
10.1101/2022.06.14.496078 — neuroscience — Posted on 2022-06-16
1900 Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice
Rigter, P.; Wallaard, I.; Aghadavoud Jolfaei, M.; Kingma, J.; Post, L.; Elgersma, M.; Elgersma, Y.; van Woerden, G.
10.1101/2022.06.14.496142 — neuroscience — Posted on 2022-06-17
1906 Integrative deep learning analysis improves colon adenocarcinoma patient stratification at risk for mortality
Zhou, J.; Foroughi pour, A.; Deirawan, H.; Daaboul, F.; Aung, T.; Beydoun, R.; Ahmed, F. S.; Chuang, J. H.
10.1101/2022.06.13.495227 — pathology — Posted on 2022-06-16
1907 A novel attention-based peptide language model for dipeptidyl peptidase-IV inhibitory peptides mining
Guan, C.; Luo, J.; Li, S.; Tan, Z. L.; Li, J.; Wu, Z.; Wang, Y.; Chen, H.; Yamamoto, N.; Zhang, C.; Chen, J.; Xing, X.-H.
10.1101/2022.06.13.495896 — bioinformatics — Posted on 2022-06-16
1908 Identification of cancer-keeping genes as therapeutic targets by finding network control hubs
Zhang, X.; Pan, C.; Wei, X.; Yu, M.; Liu, S.; An, J.; Yang, J.; Wei, B.; Hao, W.; Yao, Y.; Zhu, Y.; Zhang, W.
10.1101/2022.06.13.495906 — bioinformatics — Posted on 2022-06-16
1913 Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction
Kageyama, T.; Shimizu, A.; Anakama, R.; Nakajima, R.; Suzuki, K.; Okubo, Y.; Fukuda, J.
10.1101/2022.06.13.495917 — bioengineering — Posted on 2022-06-16
1914 Void volume fraction of granular scaffolds
Riley, L.; Wei, G.; Bao, Y.; Cheng, P.; Wilson, K. L.; Liu, Y.; Gong, Y.; Segura, T.
10.1101/2022.06.14.496197 — bioengineering — Posted on 2022-06-16
1917 Transposable element-mediated rearrangements are prevalent in human genomes
Balachandran, P.; Walawalkar, I. A.; Flores, J. I.; Dayton, J. N.; Audano, P. A.; Beck, C. R.
10.1101/2022.06.16.496479 — genomics — Posted on 2022-06-16
1918 Immune gene expression in the mosquito vector Culex quinquefasciatus during an avian malaria infection
Garcia-Longoria Batanete, L.; Ahren, D.; Berthomieu, A.; Kalbskopf, V.; Rivero, A.; Hellgren, O.
10.1101/2022.06.14.496119 — evolutionary biology — Posted on 2022-06-16
1919 COORDINATION BETWEEN EMBRYO GROWTH AND TROPHOBLAST MIGRATION UPON IMPLANTATION DELINEATES MOUSE EMBRYOGENESIS
Bondarenko, V.; Nikolaev, M.; Kromm, D.; Belousov, R.; Wolny, A.; Rezakhani, S.; Hugger, J.; Uhlmann, V.; Hufnagel, L.; Kreshuk, A.; Ellenberg, J.; Erzberger, A.; Lutolf, M. P.; Hiiragi, T.
10.1101/2022.06.13.495767 — developmental biology — Posted on 2022-06-16
1921 Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
Maserumule, C.; Passemar, C.; Oh, O.; Hegyi, K.; Brown, K.; Weimann, A.; Dinan, A.; Davila, S.; Klapholz, C.; Bryant, J.; Verma, D.; Gadwa, J.; Krishnananthasivam, S.; Vongtongsalee, K.; Kendall, E.; Trelles, A.; Hibberd, M.; Prados-Rosales, R.; Andi, K.; Kumar, S.; Ordway, D.; MacAry, P. A.; Floto, R. A.
10.1101/2022.06.14.496072 — immunology — Posted on 2022-06-16
1926 Identification of secreted proteins by comparison of protein abundance in conditioned media and cell lysates.
Abbineni, P. S.; Tang, V. T.; da Veiga Leprevost, F.; Basrur, V.; Xiang, J.; Nesvizhskii, A. I.; Ginsburg, D.
10.1101/2022.06.16.496407 — biochemistry — Posted on 2022-06-16
1929 Human threat learning is associated with gut microbiota composition
Oyarzun, J. P.; Kuntz, T. M.; Stussi, Y.; Karaman, O. T.; Vranos, S.; Callaghan, B. L.; Huttenhower, C.; Phelps, E. A.
10.1101/2022.06.13.495985 — animal behavior and cognition — Posted on 2022-06-16
1930 Altered sequencing success at non-B-DNA motifs
Weissensteiner, M. H.; Cremona, M. A.; Guiblet, W.; Stoler, N.; Harris, R. S.; Cechova, M.; Chiaromonte, F.; Huang, Y.-F.; Makova, K. D.
10.1101/2022.06.13.495922 — genomics — Posted on 2022-06-16
1931 The Chlamydomonas Genome Project, version 6: reference assemblies for mating type plus and minus strains reveal extensive structural mutation in the laboratory
Craig, R. J.; Gallaher, S. D.; Shu, S.; Salomé, P.; Jenkins, J. W.; Blaby-Haas, C. E.; Purvine, S. O.; O'Donnell, S.; Barry, K.; Grimwood, J.; Strenkert, D.; Kropat, J.; Daum, C.; Yoshinaga, Y.; Goodstein, D. M.; Vallon, O.; Schmutz, J.; Merchant, S. S.
10.1101/2022.06.16.496473 — genomics — Posted on 2022-06-16
1933 Optimizing Cryo-FIB Lamellas for sub-5 Angstrom in situ Structural Biology
Khavnekar, S.; Vrbovska, V.; Zaoralova, M.; Kelley, R.; Beck, F.; Klumpe, S.; Kotecha, A.; Plitzko, J. M.; Erdmann, P. S.
10.1101/2022.06.16.496417 — molecular biology — Posted on 2022-06-16
1938 The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis
Pleuger, C.; Ai, D.; Hoppe, M. L.; Winter, L. T.; Bohnert, D.; Karl, D.; Guenther, S.; Epelman, S.; Kantores, C.; Fijak, M.; Ravens, S.; Middendorff, R.; Mayer, J. U.; Loveland, K. L.; Hedger, M. P.; Bhushan, S.; Meinhardt, A.
10.1101/2022.06.13.495924 — immunology — Posted on 2022-06-16
1939 GM-CSF drives immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
Paust, H.-J.; Song, N.; DeFeo, D.; Asada, N.; Tuzlak, S.; Zhao, Y.; Riedel, J.-H.; Hellmig, M.; Sivayoganathan, A.; Peters, A.; Kaffke, A.; Borchers, A.; Wenzel, U. O.; Steinmetz, O. M. S. M.; Tiegs, G.; Meister, E.; Lindenmeyer, M. T.; Hoxha, E.; Stahl, R. A.; Huber, T. B.; Bonn, S.; Meyer-Schwesinger, C.; Wiech, T.; Turner, J.-E.; Becher, B.; Krebs, C. F.; Panzer, U. P.
10.1101/2022.06.13.495915 — immunology — Posted on 2022-06-16
1940 Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation
Smith, J. N. P.; Cordova, B. A.; Richardson, B.; Christo, K. F.; Campanelli, J.; Broncano, A. V.; Chen, J.; Lee, J.; Cameron, S. J.; Lathia, J. D.; Goodman, W. A.; Cameron, M. J.; Desai, A. B.
10.1101/2022.06.13.495897 — immunology — Posted on 2022-06-16
1941 Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses
Ambler, W. G.; Chalasani, M. L. S.; Seltzer, E.; Sim, J.; Shin, J.; Schwartz, N.; Dasoveanu, D.; Carballo, C.; Sevim, E.; Rodeo, S.; Erkan, D.; Kataru, R. P.; Mehrara, B.; Lu, T. T.
10.1101/2022.06.13.495930 — immunology — Posted on 2022-06-16
1942 Caecal dysfunction in the NL3R451C mouse model of autism
Lee, C. Y. Q.; Balasuriya, G. K.; Herath, M.; Franks, A. E.; Hill, E. L.
10.1101/2022.06.15.494637 — neuroscience — Posted on 2022-06-16
1945 A multiomics comparison of weight loss interventions shows the distinct effects of bariatric surgery and intermittent fasting on hepatic metabolism
Haran, A.; Bergel, M.; Kleiman, D.; Hefetz, L.; Israeli, H.; Weksler-Zangen, S.; Agranovic, B.; Abramovich, I.; Ben-Haroush Schyr, R.; Gottlieb, E.; Ben-Zvi, D.
10.1101/2022.06.13.495926 — physiology — Posted on 2022-06-16
1949 Evaluation of targeted oxidative stress induced by oxygen-ozone gas mixtures in vitro after ischemic induction
Orlandin, J. R.; Santos, S. I. P.; Machado, L. C.; Fantinato Neto, P.; Bressan, F. F.; Pieri, N. C. G.; Recchia, K.; Coutinho, M. d. P.; Pinto, P. A. F.; Santucci, A.; Travagli, V.; Ambrosio, C. E.
10.1101/2022.06.16.496274 — molecular biology — Posted on 2022-06-16
1950 Age-associated Differences in the Human Lung Extracellular Matrix
Koloko Ngassie, M. L.; De Vries, M.; Borghuis, T.; Timens, W.; Sin, D. D.; Nickle, D.; Joubert, P.; Horvatovich, P.; Marko-Varga, G.; Teske, J. J.; Vonk, J. M.; Gosens, R.; Prakash, Y. S.; Burgess, J.; Brandsma, C.-A.
10.1101/2022.06.16.496465 — molecular biology — Posted on 2022-06-16
1952 Using Watershed Characteristics for Improving Fecal Source Identification
Hart, J. J.; Jamison, M. N.; McNair, J. N.; Woznicki, S. A.; Jordan, B.; Rediske, R. R.
10.1101/2022.06.16.496426 — microbiology — Posted on 2022-06-16
1953 Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Lizcano-Perret, B.; Lardinois, C.; Wavreil, F.; Hauchamps, P.; Herinckx, G.; Sorgeloos, F.; Vertommen, D.; Gatto, L.; Michiels, T.
10.1101/2022.06.16.496404 — microbiology — Posted on 2022-06-16
1954 The complex roles of genomic DNA modifications of bacteriophage T4 in resistance to nuclease-based defense systems of E. coli
Wang, S.; Sun, E.; Liu, Y.; Yin, B.; Zhang, X.; Li, M.; Huang, Q.; Tan, C.; Qian, P.; Rao, V. B.; Tao, P.
10.1101/2022.06.16.496414 — microbiology — Posted on 2022-06-16
1955 Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via facilitation of dopamine release
Liu, X.; Vickstrom, C. R.; Yu, H.; Liu, S.; Snarrenberg, S. T.; Friedman, V.; Mu, L.; Chen, B.; Kelly, T. J.; Baker, D. A.; Liu, Q.-s.
10.1101/2022.06.13.495971 — neuroscience — Posted on 2022-06-16
1958 Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synuclein
Dhakal, S.; Robang, A. S.; Bhatt, N.; Pungamalai, N.; Fung, L.; Kayed, R.; Paravastu, A. K.; Rangachari, V.
10.1101/2022.06.14.496041 — biophysics — Posted on 2022-06-16
1959 DNA double helix, a tiny electromotor
Maffeo, C.; Quednau, L.; Wilson, J.; Aksimentiev, A.
10.1101/2022.06.13.495958 — biophysics — Posted on 2022-06-16
1960 Early selection of the amino acid alphabet was adaptively shaped by biophysical constraints of foldability
Makarov, M.; Rocha, A. C. S.; Krystufek, R.; Cherepashuk, I.; Dzmitruk, V.; Charnavets, T.; Faustino, A. M.; Lebl, M.; Fujishima, K.; Fried, S. D.; Hlouchova, K.
10.1101/2022.06.14.495995 — biophysics — Posted on 2022-06-16
1963 Automated non-lethal moth traps can be used for robust estimates of moth abundance
Mielke Moeglich, J.; Lampe, P.; Fickus, M.; Gottwald, J.; Nauss, T.; Brandl, R.; Braendle, M.; Friess, N.; Freisleben, B.; Heidrich, L.
10.1101/2022.06.13.495870 — ecology — Posted on 2022-06-16
1965 Characterizing the diversity of L2/3 human neocortical neurons in epilepsy
Kushner, J. K.; Hoffman, P.; Brzezinski, C.; Huntsman, M. M.; Alexander, A. L.
10.1101/2022.06.13.495678 — neuroscience — Posted on 2022-06-16
1968 Biphasic JNK-Erk Signaling Separates Induction and Maintenance of Cell Senescence after DNA Damage
Netterfield, T. S.; Ostheimer, G. J.; Tentner, A. R.; Sorger, P. K.; Janes, K. A.; Lauffenburger, D. A.; Yaffe, M. B.
10.1101/2022.06.15.496288 — systems biology — Posted on 2022-06-16
1971 A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway
Villamar-Cruz, O.; Loza-Mejia, M. A.; Vivar-Sierra, A.; Saldivar-Ceron, H. I.; Patino-Lopez, G.; Olguin, J. E.; Terrazas, L. I.; Armas-Lopez, L.; Avila-Moreno, F.; Saha, S.; Chernoff, J.; Camacho-Arroyo, I.; Arias-Romero, L. E.
10.1101/2022.06.14.496178 — cancer biology — Posted on 2022-06-16
1972 Energy Landscapes from Cryo-EM Snapshots: A Benchmarking Study
Dsouza, R.; Mashayekhi, G.; Etmadpour, R.; Schwander, P.; Ourmazd, A.
10.1101/2022.06.13.495454 — biophysics — Posted on 2022-06-16
1979 Evidence for grid-cell-related activity in the time domain
Peters-Founshtein, G.; Dafni-Merom, A.; Monsa, R.; Arzy, S.
10.1101/2022.06.14.476894 — neuroscience — Posted on 2022-06-16
1982 Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal Organoids
Kim, H. J.; OHara-Wright, M.; Kim, D.; Loi, T. H.; Lim, B. Y.; Jamieson, R. V.; Cordero, A. G.; Yang, P.
10.1101/2022.06.13.495996 — systems biology — Posted on 2022-06-16
1983 AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy
DAS, O.; KUNDU, J.; GHOSH, A.; GAUTAM, A.; GHOSH, S.; CHAKRABORTY, M.; MASID, A.; GAURI, S. S.; MITRA, D.; DUTTA, M.; MUKHERJEE, B.; SINHA, S.; BHAUMIK, M.
10.1101/2022.06.13.496022 — systems biology — Posted on 2022-06-16
1984 Isolation of a novel heterodimeric PSII complex via strep-tagged PsbO
Lambertz, J.; Meier-Credo, J.; Kucher, S.; Bordignon, E.; Langer, J. D.; Nowaczyk, M. M.
10.1101/2022.06.15.496312 — plant biology — Posted on 2022-06-16
1985 Temporal and spatial frameworks supporting plant responses to vegetation proximity
PASTOR-ANDREU, P.; Moreno-Romero, J.; URDIN-BRAVO, M.; PALAU-RODRIGUEZ, J.; PAULISIC, S.; KASTANAKI, E.; VIVES-PERIS, V.; GOMEZ-CADENAS, A.; RODRIGUEZ-VILLALON, A.; MARTINEZ GARCIA, j.
10.1101/2022.06.16.496398 — plant biology — Posted on 2022-06-16
1989 G-quadruplex recognition by DARPIns through epitope/paratope analogy
Miclot, T.; Bignon, E.; Terenzi, A.; Grandemange, S.; Barone, G.; MONARI, A.
10.1101/2022.06.13.495947 — biophysics — Posted on 2022-06-16
1990 Spectroscopic and QM/MM studies of the Cu(I) binding site of the plant ethylene receptor ETR1
Cutsail, G.; Schott-Verdugo, S.; Müller, L.; DeBeer, S.; Groth, G.; Gohlke, H.
10.1101/2022.06.13.495978 — biophysics — Posted on 2022-06-16
1993 The complete cell atlas of an aging multicellular organism
Roux, A. E.; Yuan, H.; Podshivalova, K.; Hendrickson, D.; Kerr, R.; Kenyon, C.; Kelley, D. R.
10.1101/2022.06.15.496201 — genomics — Posted on 2022-06-16
1997 RNA polymerase II pausing contributes to maintain chromatin organization in erythrocytes
Penagos-Puig, A.; Claudio-Galeana, S.; Stephenson-Gussinye, A.; Jacome-Lopez, K.; Aguilar-Lomas, A.; Perez-Molina, R.; Furlan-Magaril, M.
10.1101/2022.06.16.496295 — molecular biology — Posted on 2022-06-16
1999 Temporal dynamics of cholinergic activity in the septo-hippocampal system
Kopsick, J. D.; Hartzell, K.; Lazaro, H.; Nambiar, P.; Hasselmo, M. E.; Dannenberg, H.
10.1101/2022.06.12.495208 — neuroscience — Posted on 2022-06-16
2005 CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms
Bamgboye, M. A.; Herold, K. G.; Vieira, D. C. O.; Traficante, M. K.; Rogers, P. J.; Ben-Johny, M.; Dick, I. E.
10.1101/2022.06.13.495975 — biophysics — Posted on 2022-06-16
2006 An anti-steatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement
Castillo-Quan, J. I.; Steinbaugh, M. J.; Fernandez-Cardenas, L. P.; Pohl, N. K.; Wu, Z.; Zhu, F.; Moroz, N.; Teixeira, V.; Bland, M. S.; Lehrbach, N. J.; Mazzeo, L. E. M.; Teufl, M.; Blackwell, T. K.
10.1101/2022.06.15.496302 — cell biology — Posted on 2022-06-16
2007 Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry
Ampartzidis, I.; Efstathiou, C.; Paonessa, F.; Wilson, T.; McCann, C.; Greene, N.; Copp, A.; Livesey, F. J.; Elvassore, N.; Giobbe, G. G.; De Coppi, P.; Maniou, E.; Galea, G. L.
10.1101/2022.06.15.496231 — cell biology — Posted on 2022-06-16
2010 The Caenorhabditis elegans centrosome is surrounded by a membrane reticulum, the centriculum, that affects centrosome size and function
Maheshwari, R.; Rahman, M. M.; Drey, S.; Onyundo, M.; Fabig, G.; Martinez, M. A. Q.; Matus, D. Q.; MÜller-Reichert, T.; Cohen-Fix, O.
10.1101/2022.06.15.496339 — cell biology — Posted on 2022-06-16
2011 Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
Mason, D. E.; Goeckel, M.; Vega, S. L.; Wu, P.-H.; Johnson, D.; Heo, S.-J.; Wirtz, D.; Burdick, J. A.; Wood, L.; Chow, B. Y.; Stratman, A. N.; Boerckel, J. D.
10.1101/2022.06.15.496293 — cell biology — Posted on 2022-06-16
2012 Skin-resident immune cells engulf axonal debris in adult epidermis
Peterman, E.; Quitevis, E.; Horton, E.; Aelmore, R.; White, E.; Sagasti, A.; Rasmussen, J. P.
10.1101/2022.06.15.496311 — cell biology — Posted on 2022-06-16
2013 Cytoplasmic divisions without nuclei
Bakshi, A.; Echegaray Iturra, F.; Alamban, A.; Rosas-Salvans, M.; Dumont, S.; Aydogan, M. G.
10.1101/2022.06.15.496343 — cell biology — Posted on 2022-06-16
2014 SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodeling
Torices, S.; Motta, C. S.; da Rosa, B. G.; Marcos, A. C.; Alvarez-Rosa, L.; Siqueira, M.; Moreno-Rodriguez, T.; Matos, A.; Caetano, B.; Martins, J.; Loiola, E.; Gladulich, L.; Bagshaw, O. R.; Stuart, J. A.; Siqueira, M. M.; Stipursky, J.; Toborek, M.; Adesse, D.
10.1101/2022.06.16.496324 — cell biology — Posted on 2022-06-16
2015 The Omicron variant BA.1.1 presents a lower pathogenicity than B.1 D614G and Delta variants in a feline model of SARS-CoV-2 infection
Martins, M.; do Nascimento, G. M.; Nooruzzaman, M.; Yuan, F.; Chen, C.; Caserta, L. C.; Miller, A. D.; Whittaker, G. R.; Fang, Y.; Diel, D. G.
10.1101/2022.06.15.496220 — microbiology — Posted on 2022-06-16
2016 Spike independent infection of human coronavirus 229E in bat cells
Mah, M. G.; Linster, M.; Low, D. H.; Yan, Z.; Jayakumar, J.; Samsudin, F.; Wong, F. Y.; Bond, P. J.; Mendenhall, I. H.; Su, Y. C.; Smith, G. J.
10.1101/2021.09.18.460924 — microbiology — Posted on 2022-06-16
2017 Oxysterols drive inflammation via GPR183 during influenza virus and SARS-CoV-2 infection
Foo, C. X.; Bartlett, S.; Chew, K. Y.; Ngo, M. D.; Bielefeldt-Ohmann, H.; Arachchige, B. J.; Matthews, B.; Reed, S.; Wang, R.; Sweet, M. J.; Burr, L.; Sinclair, J. E.; Parry, R.; Khromykh, A.; Short, K. R.; Rosenkilde, M. M.; Ronacher, K.
10.1101/2022.06.14.496214 — immunology — Posted on 2022-06-16
2018 Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c
Severn, C. E.; Oates, T. C.; Moura, P. L.; Cross, S. J.; Roberts, K.; Baum, H. E.; Haydn-Smith, K.; Wilson, M. C.; Heesom, K. J.; Toye, A. M.
10.1101/2022.06.13.495868 — immunology — Posted on 2022-06-16
2022 Molecular Transport of the Zika Virus by the Human Cytoplasmic Dynein-1
Zavala-Vargas, D. I.; Carbajal, G. V.; Cedillo-Barron, L.; Filisola-Villasenor, J. G.; Ramirez, R. R.; Ludert, J. E.; Morales-Rios, E.
10.1101/2022.06.15.496315 — biochemistry — Posted on 2022-06-16
2027 The energy requirements of ion homeostasis determine the lifespan of starving bacteria
Schink, S. J.; Polk, M.; Athaide, E.; Mukherjee, A.; Ammar, C.; Liu, X.; Oh, S.; Chang, Y.-F.; Basan, M.
10.1101/2021.11.22.469587 — microbiology — Posted on 2022-06-16
2031 Evolution of miRNA binding sites and regulatory networks in cichlids
Mehta, T. K.; Penso-Dolfin, L.; Nash, W. K.; Roy, S.; Di Palma, F.; Haerty, W.
10.1101/2021.12.14.472604 — molecular biology — Posted on 2022-06-16
2032 Age-related declines in neural selectivity manifest differentially during encoding and recognition
Pauley, C.; Sommer, V. R.; Kobelt, M.; Keresztes, A.; Werkle-Bergner, M.; Sander, M. C.
10.1101/2021.04.29.441936 — neuroscience — Posted on 2022-06-16
2035 Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals
Charles, S.; Gestin, O.; Bruset, J.; Lamonica, D.; Baudrot, V.; Chaumot, A.; Geffard, O.; LACOUE-LABARTHE, T.; Lopes, C.
10.1101/2022.04.29.490045 — pharmacology and toxicology — Posted on 2022-06-16
2037 Conserved reward-mediated, reinforcement-learning mechanisms in Pavlovian and instrumental tasks
Moin Afshar, N.; Cinotti, F.; Martin, D. A.; Khamassi, M. A.; Calu, D. J.; Taylor, J. R.; Groman, S. M.
10.1101/2022.06.12.495805 — animal behavior and cognition — Posted on 2022-06-16
2038 Ebony underpins Batesian mimicry in an insect melanic polymorphism
Foster, B. J.; McCulloch, G. A.; Foster, Y.; Kroos, G. C.; Waters, J. M.
10.1101/2022.06.13.495778 — evolutionary biology — Posted on 2022-06-16
2039 Kiss and spit metabolomics highlights the role of the host cN-II enzyme on purine metabolism during pathogen infection
Gallego-Lopez, G. M.; Olson, W. J.; Tibabuzo-Perdomo, A. M.; Stevenson, D.; Amador-Noguez, D.; Knoll, L. J.
10.1101/2022.06.15.496273 — microbiology — Posted on 2022-06-16
2041 PICLN modulates alternative splicing and ensures adaptation to light and temperature changes in plants
Mateos, J. L.; Sanchez, S. E.; Legris, M.; Esteve-Bruna, D.; Torchio, J. C.; Petrillo, E.; Goretti, D.; Blanco-Tourinan, N.; Seymour, D. K.; Schmid, M.; Weigel, D.; Alabadi, D.; Yanovsky, M. J.
10.1101/2022.06.14.496170 — plant biology — Posted on 2022-06-16
2044 High overexploitation risk and management shortfall in highly traded requiem sharks
Sherman, C. S.; Digel, E. D.; Zubick, P.; Eged, J.; Haque, A. B.; Matsushiba, J. H.; Simpfendorfer, C. A.; Sant, G.; Dulvy, N. K.
10.1101/2022.06.09.495558 — ecology — Posted on 2022-06-16
2048 F-actin regulates polarized secretion of pollen tube attractants in Arabidopsis synergid cell.
Susaki, D.; Izumi, R.; Oi, T.; Takeuchi, H.; Shin, J. M.; Sugi, N.; Kinoshita, T.; Higashiyama, T.; Kawashima, T.; Maruyama, D.
10.1101/2022.06.14.496136 — plant biology — Posted on 2022-06-16
2050 LipidMS 3.0: an R-package and a web-based tool for LC-MS/MS data processing and lipid annotation
Alcoriza-Balaguer, M. I.; Garcia-Canaveras, J. C.; Ripoll-Esteve, F. J.; Roca, M.; Lahoz, A.
10.1101/2022.02.25.476005 — bioinformatics — Posted on 2022-06-16
2051 Insights for disease modeling from single cell transcriptomics of iPSC-derived neurons and astrocytes across differentiation time and co-culture
Das, D.; Sonthalia, S.; Stein-O'Brien, G. G.; Wahbeh, M.; Feuer, K.; Colantuoni, C.; Machairaki, V.; Avramopoulos, D.
10.1101/2022.06.15.495952 — genetics — Posted on 2022-06-16
2052 The Neural Architecture of Theory-based Reinforcement Learning
Tomov, M. S.; Tsividis, P. A.; Pouncy, T.; Tenenbaum, J. B.; Gershman, S. J.
10.1101/2022.06.14.496001 — neuroscience — Posted on 2022-06-16
2059 Hotspot of de novo telomere addition stabilizes linear amplicons in yeast grown in sulfate-limiting conditions
Hoerr, R. E.; Eng, A.; Payen, C.; DiRienzi, S. C.; Raghuraman, M. K.; Dunham, M. J.; Brewer, B. J.; Friedman, K. L.
10.1101/2022.06.12.495855 — genetics — Posted on 2022-06-15
2060 Discovery and Genomic Characterization of a Novel Henipavirus, Angavokely virus, from fruit bats in Madagascar
Madera, S.; Kistler, A.; Ranaivoson, H. C.; Ahyong, V.; Andrianiaina, A.; Andry, S.; Raharinosy, V.; Randriambolamanantsoa, T. H.; Ravelomanantsoa, N. A. F.; Tato, C. M.; DeRisi, J. L.; Aguilar, H. C.; Lacoste, V.; Dussart, P.; Heraud, J.-M.; Brook, C. E. L.
10.1101/2022.06.12.495793 — evolutionary biology — Posted on 2022-06-15
2062 Genetic exchange in Leishmania is facilitated by IgM natural antibodies
Serafim, T. D.; Iniguez, E.; F. Barletta, A. B.; Doehl, J. S. P.; Short, M.; Lack, J.; Cecilio, P.; Nair, V.; Disotuar, M.; Wilson, T.; Coutinho-Abreu, I. V.; Oliveira, F.; Meneses, C.; Barillas-Mury, C.; Andersen, J.; Ribeiro, J. M. C.; Beverley, S. M.; Kamhawi, S.; Valenzuela, J. G.
10.1101/2022.06.09.495557 — microbiology — Posted on 2022-06-15
2064 Pharmacological activation of the mitochondrial stress protease OMA1 reveals a therapeutic liability in Diffuse Large B-Cell Lymphoma
Kostura, M. J.; Stocum, M.; Hembrough, T.; Cooper, A.; Anantha, A.; Luther, M.; Levine, J.; Schwarzer, A.; Kleppa, M.-J.; Schambach, A.; Doerrie, A.; Kotlyarov, A.; Gaestel, M.; Hannink, M.; Oliveira, M.; Liesa, M.; Stiles, L.; Slattery, S. D.
10.1101/2022.06.12.495213 — cancer biology — Posted on 2022-06-15
2066 Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
Hilander, T.; Monteuuis, G.; Awadhpersad, R.; Broda, K.; Pohjanpelto, M.; Pyman, E.; Singh, S. K.; Nyman, T. A.; Crevel, I.; Balboa, D.; Battersby, B. J.; Jackson, C. B.; Carroll, C. J.
10.1101/2022.06.15.495910 — molecular biology — Posted on 2022-06-15
2071 CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury
McKendrick, J. G.; Jones, G.-R.; Elder, S. S.; Mercer, E.; Magalhaes, M. S.; Rocchi, C.; Hegarty, L. M.; Johnson, A. L.; Schneider, C.; Becher, B.; Pridans, C.; Mabbott, N. A.; Liu, Z.; Ginhoux, F.; Bajenoff, M.; Gentek, R.; Bain, C. C.; Emmerson, E.
10.1101/2022.06.12.495803 — immunology — Posted on 2022-06-15
2073 Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
Jalbert, E.; Liu, C.; Mave, V.; Lang, N.; Kagal, A.; Valvi, C.; Paradkar, M.; Gupte, N.; Lokhande, R.; Bharadwaj, R.; Kulkarni, V.; Gupta, A.; Weinberg, A.
10.1101/2022.06.13.495865 — immunology — Posted on 2022-06-15
2074 Closed-loop control and recalibration of place cells by optic flow
Madhav, M. S.; Jayakumar, R. P.; Li, B. Y.; Savelli, F.; Knierim, J. J.; Cowan, N. J.
10.1101/2022.06.12.495823 — neuroscience — Posted on 2022-06-15
2075 Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid beta aggregates in vivo in a mouse model of Alzheimer's disease
Calvo-Rodriguez, M.; Kharitonova, E.; Snyder, A.; Hou, S.; Sanchez-Mico, M. V.; Das, S.; Fan, Z.; Shirani, H.; Nilsson, P.; Serrano-Pozo, A.; Bacskai, B.
10.1101/2022.06.12.495840 — neuroscience — Posted on 2022-06-15
2077 Pharmacologic inhibition of EPHA2 decreases inflammation and pathological endochondral ossification in osteoarthritis
Blanco, M. N. F.; Lesage, R.; Kops, N.; Fahy, N.; Bekedam, F. T.; Chavli, A.; Bastiaansen-Jenniskens, Y. M.; Geris, L.; Chambers, M. G.; Pitsillides, A. A.; Narcisi, R.; van Osch, G. J. V. M.
10.1101/2022.06.12.495737 — pharmacology and toxicology — Posted on 2022-06-15
2080 STRAINS: A Big Data Method for Classifying Cellular Response to Stimuli at the Tissue Scale
Zheng, J.; Jackson, T. W.; Fortier, L. A.; Bonassar, L. J.; Delco, M.; Cohen, I.
10.1101/2022.06.12.495830 — biophysics — Posted on 2022-06-15
2081 Wide-Field Stokes Polarimetric Microscopy for Second Harmonic Generation Imaging
Castano, L. U.; Mirsanaye, K.; Kontenis, L.; Krouglov, S.; Akens, M.; Barzda, V.
10.1101/2022.06.12.495834 — biophysics — Posted on 2022-06-15
2084 An engineered xCas12i with high activity, high specificity and broad PAM range
Zhang, H.; Kong, X.; Xue, M.; Wang, Z.; Wei, Y.; Wang, H.; Zhou, J.; Zhang, W.; Xu, M.; Shen, X.; Li, J.; Hu, J.; Zhong, N.; Zhou, Y.; Yang, H.
10.1101/2022.06.15.496255 — bioengineering — Posted on 2022-06-15
2086 Constitutive Inhibition of Transient Receptor Potential CanonicalType 6 (TRPC6) by O-GlcNAcylation at Threonine-221
Kass, D. A.; Mishra, S.; Ma, J.; Sasaki, M.; Farinelli, F.; Page, R. C.; Ranek, M. J.; Zachara, N.
10.1101/2022.06.15.496344 — biochemistry — Posted on 2022-06-15
2087 Massively Parallel Dissection of RNA in RNA-protein interactions in vivo
Hass, E. P.; Lee, Y. H.; Campodonico, W.; Lee, Y. K.; Lasda, E.; Shah, J. S.; Rinn, J.; Hwang, T.
10.1101/2022.06.13.495920 — genomics — Posted on 2022-06-15
2088 Genomic prediction with whole-genome sequence data in intensely selected pig lines
Ros-Freixedes, R.; Johnsson, M.; Whalen, A.; Chen, C.-Y.; Valente, B. D.; Herring, W. O.; Gorjanc, G.; Hickey, J. M.
10.1101/2022.02.02.478838 — genomics — Posted on 2022-06-15
2089 Hotspot of de novo telomere addition stabilizes linear amplicons in yeast grown in sulfate-limiting conditions
Hoerr, R. E.; Eng, A.; Payen, C.; DiRienzi, S. C.; Raghuraman, M. K.; Dunham, M. J.; Brewer, B. J.; Friedman, K. L.
10.1101/2022.06.12.495855 — genetics — Posted on 2022-06-15
2090 The columnar structure of human telomeric chromatin suggests mechanisms for telomere maintenance
Soman, A.; Wong, S. Y.; Korolev, N.; Surya, W.; Lattman, S.; Vogirala, V. K.; Chen, Q.; Berezhnoy, N. V.; van Noort, J.; Rhodes, D.; Nordenskiöld, L.
10.1101/2022.06.15.496090 — molecular biology — Posted on 2022-06-15
2092 DHCR7 as a novel regulator of ferroptosis in hepatocytes
Yamada, N.; Karasawa, T.; Komada, T.; Matsumura, T.; Baatarjav, c.; Ito, J.; Nakagawa, K.; Yamamuro, D.; Ishibashi, S.; Miura, K.; Sata, N.; Takahashi, M.
10.1101/2022.06.15.496212 — molecular biology — Posted on 2022-06-15
2094 The membrane activity of the amphibian Temporin B peptide analog TB_KKG6K sheds light on the mechanism that kills Candida albicans
Kakar, A.; Sastré-Velásquez, L. E.; Hess, M. W.; Galgóczy, L.; Papp, C.; Holzknecht, J.; Romanelli, A.; Váradi, G.; Malanovic, N.; Marx, F.
10.1101/2022.06.15.496139 — microbiology — Posted on 2022-06-15
2095 Zoonotic avian influenza viruses evade human BTN3A3 restriction
Pinto, R. M.; Bakshi, S.; Lytras, S.; Zakaria, M. K.; Swingler, S.; Worrell, J. C.; Herder, V.; Varjak, M.; Cameron-Ruiz, N.; Collados-Rodriguez, M.; Varela, M.; Wickenhagen, A.; Loney, C.; Pei, Y.; Hughes, J.; Valette, E.; Turnbull, M. L.; Furnon, W.; Hargrave, K. E.; Gu, Q.; Orr, L.; Taggart, A.; Boutell, C.; Grey, F.; Hutchinson, E.; Digard, P.; Monne, I.; Wootton, S. K.; MacLeod, M. K. L.; Wilson, S. J.; Palmarini, M.
10.1101/2022.06.14.496196 — microbiology — Posted on 2022-06-15
2096 Sphingolipids protect ergosterol in the Leishmania major membrane from sterol-binding toxins
Haram, C.; Moitra, S.; Keane, R.; Kuhlmann, F. M.; Frankfater, C.; Hsu, F.-f.; Beverley, S. M.; Zhang, K.; Keyel, P. A.
10.1101/2022.06.15.496300 — microbiology — Posted on 2022-06-15
2097 A GPU-based computational framework that bridges Neuron simulation and Artificial Intelligence
Zhang, Y.; He, G.; Liu, X.; Hjorth, J.; Kozlov, A.; He, Y.; Zhang, S.; Ma, L.; Kotaleski, J.; Tian, Y.; Grillner, S.; Du, K.; Huang, T.
10.1101/2022.06.12.495784 — neuroscience — Posted on 2022-06-15
2099 Modes of inhibition used by phage anti-CRISPRs to evade type I-C Cascade
O'Brien, R. E.; Bravo, J. P.; Ramos, D.; Hibshman, G. N.; Wright, J. T.; Taylor, D. W.
10.1101/2022.06.15.496202 — biochemistry — Posted on 2022-06-15
2100 Investigating interspecific quorum sensing influence on cocoa fermentation quality through defined microbial cocktails
de Almeida, O. G. G.; Pereira, M. G.; Bighetti-Trevisan, R. L.; Santos, E. S.; De Campos, E. G.; Felis, G. E.; Guimaraes, L. H. S.; Polizeli, M. d. L. T. D. M.; De Martinis, B. S.; De Martinis, E. C. P.
10.1101/2022.06.14.496151 — microbiology — Posted on 2022-06-15
2101 The faecal metabolome and its determinants in inflammatory bowel disease
Vich Vila, A.; Hu, S.; Andreu-Sanchez, S.; Collij, V.; Jansen, B. H.; Augustijn, H. E.; Bolte, L.; Ruigrok, R. A. A. A.; Abu-Ali, G.; Giallourakis, C.; Schneider, J.; Parkinson, J.; Al Garawi, A.; Zhernakova, A.; Gacesa, R.; Fu, J.; Weersma, R. K.
10.1101/2022.06.15.495746 — microbiology — Posted on 2022-06-15
2102 A Novel Bacterial Speciation Process Observed in a Symbiotic Marine Population
Wang, X.; Uematsu, K.; O'Rourke, A.; Akita, T.; Kimura, K.; Tomaru, Y.; Voolstra, C. R.; Innan, H.; Luo, H.
10.1101/2022.06.15.496264 — microbiology — Posted on 2022-06-15
2104 Simultaneous classification of neuroactive compounds in zebrafish
Myers-Turnbull, D.; Taylor, J. C.; Helsell, C.; Tummino, T. A.; Mccarroll, M. N.; Alexander, R.; Ki, C. S.; Gendelev, L.; Kokel, D.
10.1101/2020.01.01.891432 — systems biology — Posted on 2022-06-15
2106 Securing algal endosymbiont communities for reef-building corals
Bouwmeester, J.; Daly, J.; Quinn, M.; Henley, E. M.; Lager, C.; Perry, R.; Page, C. A.; Hagedorn, M.
10.1101/2022.06.14.495714 — zoology — Posted on 2022-06-15
2109 Tunable control of insect pheromone biosynthesis in Nicotiana benthamiana
Kallam, K.; Moreno Gimenez, E.; Mateos Fernandez, R.; Tansley, C.; Gianoglio, S.; Orzaez, D.; Patron, N. J.
10.1101/2022.06.15.496242 — synthetic biology — Posted on 2022-06-15
2110 Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptor
Maidment, J. H.; Shimizu, M.; Vera, S.; Franceschetti, M.; Longya, A.; Stevenson, C. E.; De la Concepcion, J. C.; Bialas, A.; Kamoun, S.; Terauchi, R.; Banfield, M. J.
10.1101/2022.06.14.496076 — plant biology — Posted on 2022-06-15
2111 F-actin regulates polarized secretion of pollen tube attractants in Arabidopsis synergid cell.
Susaki, D.; Izumi, R.; Oi, T.; Takeuchi, H.; Shin, J. M.; Sugi, N.; Kinoshita, T.; Higashiyama, T.; Kawashima, T.; Maruyama, D.
10.1101/2022.06.14.496136 — plant biology — Posted on 2022-06-15
2112 The F-box cofactor UFO redirects the LEAFY floral regulator to novel cis-elements
Rieu, P.; Turchi, L.; Thevenon, E.; Zarkadas, E.; Nanao, M.; Chahtane, H.; Tichtinsky, G.; Lucas, J.; Blanc-Mathieu, R.; Zubieta, C.; Schoehn, G.; PARCY, F.
10.1101/2022.06.14.495942 — plant biology — Posted on 2022-06-15
2113 Genomic, transcriptomic, and metabolomic analysis of Traditional Chinese Medicine plant Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites
Julca, I.; Mutwil-Anderwald, D.; Manoj, V.; Khan, Z.; Lai, S. K.; Yang, L. K.; Beh, I. T.; Dziekan, J.; Lim, Y. P.; Lim, S. K.; Low, Y. W.; Lam, Y. I.; Mu, Y.; Tan, Q. W.; Nuc, P.; Choo, L. M.; Khew, G.; Loo, S.; Kam, A.; Tam, J. P.; Bozdech, Z.; Schmidt, M.; Usadel, B.; Kanagasundaram, Y. S.; Alseekh, S.; Fernie, A. R.; Li, H. Y.; Mutwil, M.
10.1101/2022.06.14.496066 — plant biology — Posted on 2022-06-15
2115 The Mediator complex regulates enhancer-promoter interactions
Ramasamy, S.; Aljahani, A.; Karpinska, M.; Cao, N.; Cruz, N.; Oudelaar, A. M.
10.1101/2022.06.15.496245 — molecular biology — Posted on 2022-06-15
2116 Microbial cysteine degradation is a source of hydrogen sulfide in oxic freshwater lakes
Tran, P. Q.; Bachand, S. C.; Hotvedt, J. C.; Kieft, K.; McDaniel, E. A.; McMahon, K. D.; Anantharaman, K.
10.1101/2021.11.30.467465 — microbiology — Posted on 2022-06-15
2117 The Omicron variant BA.1.1 presents a lower pathogenicity than B.1 D614G and Delta variants in a feline model of SARS-CoV-2 infection
Martins, M.; do Nascimento, G. M.; Nooruzzaman, M.; Yuan, F.; Chen, C.; Caserta, L. C.; Miller, A. D.; Whittaker, G. R.; Fang, Y.; Diel, D. G.
10.1101/2022.06.15.496220 — microbiology — Posted on 2022-06-15
2118 Oxysterols drive inflammation via GPR183 during influenza virus and SARS-CoV-2 infection
Foo, C. X.; Bartlett, S.; Chew, K. Y.; Ngo, M. D.; Bielefeldt-Ohmann, H.; Arachchige, B. J.; Matthews, B.; Reed, S.; Wang, R.; Sweet, M. J.; Burr, L.; Sinclair, J. E.; Parry, R.; Khromykh, A.; Short, K. R.; Rosenkilde, M. M.; Ronacher, K.
10.1101/2022.06.14.496214 — immunology — Posted on 2022-06-15
2119 GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa
Nagle, M. F.; Yuan, J.; Kaur, D.; Ma, C.; Peremyslova, E.; Jiang, Y.; Willig, C. J.; Goralogia, G. S.; Nino de Rivera, A.; McEldowney, M.; Goddard, A.; Magnuson, A.; Muchero, W.; Li, F.; Strauss, S. H.
10.1101/2022.06.14.496209 — plant biology — Posted on 2022-06-15
2120 A single-component luminescent biosensor for the SARS-CoV-2 spike protein
Ravalin, M.; Roh, H.; Suryawanshi, R.; Kumar, G. R.; Pak, J. E.; Ott, M.; Ting, A. Y.
10.1101/2022.06.15.496006 — biochemistry — Posted on 2022-06-15
2121 A wealth of novel cell-specific expressed SNVs from tumor and normal scRNA-seq datasets
Dillard, C.; Ulianova, E.; Prashant, N.; Liu, H.; Edwards, N. J.; Horvath, A.
10.1101/2022.06.12.495797 — genomics — Posted on 2022-06-15
2124 Inhibiting Spinal Cord-Specific Hsp90 Isoforms Reveals a Novel Strategy to Improve the Therapeutic Index of Opioid Treatment
Duron, D. I.; Campbell, C. S.; Chou, K.; Tanguturi, P.; Bejarano, P.; Gabriel, K. A.; Bowden, J. L.; Mishra, S.; Brackett, C.; Barlow, D.; Houseknecht, K. L.; Blagg, B. S.; Streicher, J. M.
10.1101/2021.04.14.439852 — neuroscience — Posted on 2022-06-15
2125 Technical Report on Ancient DNA analysis of 27 African Americans from Catoctin Furnace, Maryland
Harney, E.; Olalde, I.; Bruwelheide, K.; Barca, K. G.; Curry, R.; Comer, E.; Rohland, N.; Owsley, D.; Reich, D. E.
10.1101/2022.06.12.495320 — genomics — Posted on 2022-06-15
2126 Interference of Neuronal TrkB Signaling by the Cannabis-Derived Flavonoids Cannflavins A and B
Holborn, J.; Walczyk Mooradally, A.; Perrin, C.; Alural, B.; Aitchison, C.; Borenstein, A.; Khokhar, J.; Akhtar, T.; Lalonde, J.
10.1101/2022.02.03.478734 — pharmacology and toxicology — Posted on 2022-06-15
2127 Scale-free and oscillatory spectral measures of sleep stages in humans
Schneider, B.; Szalardy, O.; Ujma, P. P.; Simor, P.; Gombos, F.; Kovacs, I.; Dresler, M.; Bodizs, R.
10.1101/2022.06.09.495470 — bioinformatics — Posted on 2022-06-15
2129 High overexploitation risk and management shortfall in highly traded requiem sharks
Sherman, C. S.; Digel, E. D.; Zubick, P.; Eged, J.; Haque, A. B.; Matsushiba, J. H.; Simpfendorfer, C. A.; Sant, G.; Dulvy, N. K.
10.1101/2022.06.09.495558 — ecology — Posted on 2022-06-15
2133 A Diabetic Mice Model For Studying Skin Wound Healing
Poblete Jara, C.; Nogueira, G.; Morari, J.; Paulino do Prado, T.; Medeiros Bezerra, R.; Bombassaro, B.; Velloso, L. A.; Velander, W.; de Araujo, E. P.
10.1101/2022.05.28.493835 — physiology — Posted on 2022-06-15
2134 Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
Leibold, J.; Amor, C.; Tsanov, K. M.; Ho, Y.-J.; Sanchez-Rivera, F. J.; Feucht, J.; Baslan, T.; Chen, H.-A.; Tian, S.; Simon, J.; Wuest, A.; Wilkinson, J. E.; Lowe, S. W.
10.1101/2022.06.15.494941 — cancer biology — Posted on 2022-06-15
2135 Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer
Blanchard, Z.; Arnesen, S.; Vahrenkamp, J. M.; Rodriguez, A. C.; Jarboe, E. A.; Brown, C.; Modzelewska, K.; Lum, D. H.; Gertz, J.
10.1101/2022.06.13.495977 — cancer biology — Posted on 2022-06-15
2136 Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction
Salcedo, A.; Tarabichi, M.; Buchanan, A.; Espiritu, S. M. G.; Zhang, H.; Zhu, K.; Yang, T.-H. O.; Leshchiner, I.; Anastassiou, D.; Guan, Y.; Jang, G. H.; Haase, K.; Deshwar, A. G.; Zou, W.; Umar, I.; Dentro, S.; Wintersinger, J. A.; Chiotti, K.; Demeulemeester, J.; Jolly, C.; Scyza, L.; Ko, M.; PCAWG-11 Working Group, ; SMC-Het Participants, ; Wedge, D. C.; Morris, Q. D.; Ellrot, K.; Van Loo, P.; Boutros, P. C.
10.1101/2022.06.14.495937 — bioinformatics — Posted on 2022-06-15
2137 Aberrant splicing prediction across human tissues
Celik, M. H.; Wagner, N.; Hoelzlwimmer, F.; Yepez, V.; Mertes, C.; Prokisch, H.; Gagneur, J.
10.1101/2022.06.13.495326 — bioinformatics — Posted on 2022-06-15
2138 Imputation and polygenic score performances of human genotyping arrays in diverse populations
Nguyen, D. T.; Tran, T.; Tran, M.; Tran, K.; Pham, D.; Duong, N. T.; Nguyen, Q.; Vo, N. S.
10.1101/2022.06.14.496059 — genomics — Posted on 2022-06-15
2142 Maturational networks of fetal brain activity
Karolis, V. R.; Fitzgibbon, S. P.; Cordero-Grande, L.; Farahibozorg, S.-R.; Price, A. N.; Hughes, E. J.; Fetit, A. E.; Kyriakopoulou, V.; Pietsch, M.; Rutherford, M.; Rueckert, D.; Hajnal, J. V.; Edwards, A. D.; O'Muircheartaigh, J.; Duff, E.; Arichi, T.
10.1101/2022.06.14.495883 — neuroscience — Posted on 2022-06-15
2146 Decoding gene regulation in the mouse embryo using single-cell multi-omics
Argelaguet, R.; Lohoff, T.; Li, J. G.; Nakhuda, A.; Drage, D.; Krueger, F.; Velten, L.; Clark, S. J.; Reik, W.
10.1101/2022.06.15.496239 — developmental biology — Posted on 2022-06-15
2149 Nuclear receptor interaction protein (NRIP) as a novel actin-binding protein involved in invadosome formation for myoblast fusion
Chen, H.-H.; Han, Y.-J.; Wu, T.-C.; Yen, W.-S.; Lai, T.-Y.; Wei, P.-H.; Tsai, L.-K.; Lai, H.-J.; Tsao, Y.-P.; Chen, S.-L.
10.1101/2022.06.14.496213 — cell biology — Posted on 2022-06-15
2152 Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner
Onwubiko, U. N.; Koory, E.; Pokharel, S.; Roberts, H.; Mitoubsi, A.; Das, M. E.
10.1101/2022.06.14.496145 — cell biology — Posted on 2022-06-15
2153 Dual role of Pectin Methyl Esterase activity for plant cell growth regulation.
Gallemi Rovira, M.; Montesinos Lopez, J. C.; Zarevski, N.; Pribyl, J.; Skladal, P.; Hannezo, E.; Benkova, E.
10.1101/2022.06.14.495617 — cell biology — Posted on 2022-06-15
2155 Tracking age differences in neural distinctiveness across representational levels
Kobelt, M.; Sommer, V. R.; Keresztes, A.; Werkle-Bergner, M.; Sander, M. C.
10.1101/2020.07.06.187187 — neuroscience — Posted on 2022-06-15
2156 Long-term stability of single neuron activity in the motor system
Jensen, K. T.; Harpaz, N. K.; Dhawale, A. K.; Wolff, S. B. E.; Ölveczky, B.
10.1101/2021.10.27.465945 — neuroscience — Posted on 2022-06-15
2157 Acute sleep deprivation induces synaptic remodeling at the soleus muscle neuromuscular junction in rats
Sharma, B.; Roy, A.; Sengupta, T.; Vishwakarma, L. C.; Singh, A.; Netam, R.; Nag, T. C.; Akhtar, N.; Mallick, H. N.
10.1101/2022.06.12.495825 — neuroscience — Posted on 2022-06-15
2158 Nr4a1 regulates inhibitory circuit structure and function in the mouse brain.
Huang, M.; Pieraut, S.; Cao, J.; de Souza Polli, F.; Roncace, V.; Shen, G.; Maximov, A.
10.1101/2022.06.14.496205 — neuroscience — Posted on 2022-06-15
2160 Development of Top-Down Cortical Propagations in Youth
Pines, A. R.; Keller, A. S.; Larsen, B.; Bertolero, M.; Ashourvan, A.; Bassett, D. S.; Cieslak, M.; Covitz, S.; Fan, Y.; Feczko, E.; Houghton, A.; Rueter, A. R.; Tapera, T.; Vogel, J.; Weinstein, S. M.; Shinohara, R. T.; Fair, D.; Satterthwaite, T.
10.1101/2022.06.14.496175 — neuroscience — Posted on 2022-06-15
2161 A quantitative gibberellin signalling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem
Shi, B.; Felipo-Benavent, A.; Cerutti, G.; Galvan-Ampudia, C.; Jilli, L.; Brunoud, G.; Mutterer, J.; Vallet, E.; Sakvarelidze-Achard, L.; Daviere, J.-M.; Navarro-Galiano, A.; Walia, A.; Lazary, S.; Legrand, J.; Weinstain, R.; Jones, A. M.; Prat, S.; Achard, P.; VERNOUX, T.
10.1101/2021.06.11.448154 — plant biology — Posted on 2022-06-15
2162 Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics
Zangarelli, C.; Arnaiz, O.; Bourge, M.; Gorrichon, K.; Jaszczyszyn, Y.; Mathy, N.; Escoriza, L.; Betermier, M.; Regnier, V.
10.1101/2022.05.18.492358 — genomics — Posted on 2022-06-15
2164 Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle
Zeeshan, M.; Rashpa, R.; Ferguson, D. J. P.; Abel, S.; Chahine, Z.; Brady, D.; vaughan, s.; Moores, C. A.; Le Roch, K. G.; Brochet, M.; Holder, A. A.; Tewari, R.
10.1101/2021.05.26.445751 — cell biology — Posted on 2022-06-15
2166 Pattern Recognition Receptor for Bacterial Lipopolysaccharide in the Cytosol of Human Macrophages
Rojas-Lopez, M.; Zajac, A. S.; Wood, T. E.; Miller, K. A.; Gil Marques, M. L.; Hachey, A. C.; Kharbanda, V.; Egger, K. T.; Goldberg, M. B.
10.1101/2021.10.22.465470 — microbiology — Posted on 2022-06-15
2167 HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway
Krause, R.; COMMIT-KZN Team, ; Snyman, J.; Hwa, S.-H.; Muema, D.; Karim, F.; Ganga, Y.; Ngoepe, A.; Zungu, Y.; Gazy, I.; Bernstein, M.; Khan, K.; Mazibuko, M.; Mthabela, N.; Ramjit, D.; Limbo, O.; Jardine, J.; Sok, D.; Wilson, I. A.; Hanekom, W.; Sigal, A.; Kloverpris, H.; Ndung'u, T.; Leslie, A.
10.1101/2022.06.14.496062 — immunology — Posted on 2022-06-15
2169 DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection
Hausmann, F.; Ergen, C.; Khatri, R.; Marouf, M.; Hänzelmann, S.; Menon, R.; Kretzler, M.; Gagliani, N.; Huber, S.; Machart, P.; Bonn, S.
10.1101/2022.03.09.483600 — bioinformatics — Posted on 2022-06-15
2171 ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation
Choi, W. H.; Yun, Y.; Byun, I.; Lee, S.; Sim, J.; Levi, S.; Kim, S.; Park, S. H.; Jun, J.; Kim, K. P.; Kwon, Y. T.; Han, D.; Chiba, T.; Seok, C.; Glickman, M. H.; Lee, M. J.
10.1101/2022.06.06.495046 — biochemistry — Posted on 2022-06-15
2172 Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex
Gruszczyk, J.; Grandvuillemin, L.; Lai-Kee-Him, J.; Paloni, M.; Savva, C. G.; Germain, P.; Grimaldi, M.; Boulahtouf, A.; Kwong, H.-S.; Bous, J.; Ancelin, A.; Bechara, C.; Barducci, A.; Balaguer, P.; Bourguet, W.
10.1101/2022.05.17.491947 — biochemistry — Posted on 2022-06-15
2173 Hydrophobicity in clearwing butterflies and moths: impact of scale micro and nanostructure, and trade-off with transparency
Gomez, D.; Pairraire, J.; Pinna, C.; Arias, M.; Houssin, C.; Barbut, J.; Berthier, S.; Andraud, C.; Ondarcuhu, T.; Elias, M.
10.1101/2021.10.11.463886 — evolutionary biology — Posted on 2022-06-15
2174 Helicobacter pylori chronic infection selects for effective colonizers of metaplastic glands
O'Brien, V. P.; Jackson, L. K.; Frick, J.; Rodriguez Martinez, A. E.; Jones, D. S.; Johnston, C. D.; Salama, N. R.
10.1101/2022.06.13.496036 — microbiology — Posted on 2022-06-15
2175 Context- and scale-dependent effects of thymol bioactivity on biological networks: contributions from quail under heat stress
Fernandez, M. E.; Bonansea, R. I.; Mas, A. L.; Baroni, M. V.; Marin, R. H.; Labaque, M. C.; Kembro, J. M.
10.1101/2022.06.10.495659 — physiology — Posted on 2022-06-15
2176 AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models
Selles, M. C.; Fortuna, J. T. S.; Cercato, M. C.; Santos, L. E.; Domett, L.; Bitencourt, A. L. B.; Carraro, M. F.; Souza, A. S.; Janickova, H.; de Souza, J. M.; Alves-Leon, S.; Prado, V. F.; Prado, M. A. M.; Epstein, A. L.; Salvetti, A.; Arancio, O.; Klein, W. L.; Sebollela, A.; De Felice, F. G.; Jerusalinsky, D. A.; Ferreira, S. T.
10.1101/2022.06.10.495369 — neuroscience — Posted on 2022-06-15
2180 Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Ceddia, R. P.; Zurawski, Z.; Thompson Gray, A.; Adegboye, F.; Shi, F.; Liu, D.; Maldonado, J.; Ayala, J. E.; McGuinness, O. P.; Collins, S.; Hamm, H. E.
10.1101/2020.04.29.069138 — physiology — Posted on 2022-06-14
2181 Transformation of Human Mesenchymal Stem Cells into High-Grade Sarcomas by YAP1 and K-RAS Reflects the Undifferentiated Pleomorphic Sarcoma-Myxofibrosarcoma Disease Spectrum
Munoz, M. A.; Freeland, J.; O'Donnell, E.; Langerman, J.; Darrow, M.; Thorpe, S.; Randall, R.; Carraway, K. L.; Witte, O.; Graeber, T.; Carr-Ascher, J.
10.1101/2022.06.13.495815 — cancer biology — Posted on 2022-06-14
2183 Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogs
Donner, J.; Freyer, J.; Davison, S.; Anderson, H.; Blades, M.; Honkanen, L.; Inman, L.; Brookhart-Knox, C. A.; Louviere, A.; Forman, O. P.; Chodroff Foran, R.
10.1101/2022.06.12.495799 — genetics — Posted on 2022-06-14
2185 The cell wall polymer initiates plasma membrane partitioning in mycobacteria
Kado, T.; Akbary, Z.; Motooka, D.; Sparks, I. L.; Melzer, E. S.; Nakamura, S.; Rojas, E. R.; Morita, Y. S.; Siegrist, M. S.
10.1101/2022.06.12.495848 — molecular biology — Posted on 2022-06-14
2190 Generation and Functional Characterization of PLAP CAR-T Cells against Cervical Cancer Cells
Yekehfallah, V.; Pahlavanneshan, S.; Sayadmanesh, A.; Momtahan, Z.; Ma, B.; Basiri, M.
10.1101/2022.06.12.495798 — immunology — Posted on 2022-06-14
2192 Incilius alvarius cell-based synthesis of 5-MeO-DMT
Lerer, L.; Reynolds, E.; Varia, J.; Blakolmer, K.; Lerer, B.
10.1101/2022.05.20.492789 — bioengineering — Posted on 2022-06-14
2193 The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families
Zhong, Y.; Moghaddas Sani, H.; Paudel, B.; Low, J.; Silva, A.; Mueller, S.; Deshpande, C.; Panjikar, S.; van Oijen, A.; Mackay, J.
10.1101/2022.06.13.496015 — biochemistry — Posted on 2022-06-14
2194 Spatial distribution of metabolites in primate retina and its relevance to studies of metabolic human retinal disorders
Bonelli, R.; Ansell, B. R. E.; Woods, S. M.; Lockwood, S.; Bishop, P. N.; Khan, K. N.; Bahlo, M.; Fruttiger, M.
10.1101/2022.06.13.496007 — biochemistry — Posted on 2022-06-14
2195 Structural insights into AT-rich DNA recognition by SALL family proteins
Ru, W.; Koga, T.; Wang, X.; Guo, Q.; Gearhart, M.; Zhao, S.; Murphy, M.; Kawakami, H.; Corcoran, D.; Zhang, J.; Zhu, Z.; Yao, X.; Kawakami, Y.; Xu, C.
10.1101/2022.06.13.496009 — biochemistry — Posted on 2022-06-14
2196 Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex
Schwartz, E. A.; Bravo, J. P.; Macias, L. A.; McCafferty, C. L.; Dangerfield, T. L.; Walker, J. N.; Brodbelt, J. S.; Fineran, P. C.; Fagerlund, R. D.; Taylor, D. W.
10.1101/2022.06.13.496011 — biochemistry — Posted on 2022-06-14
2197 Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger
Hata, K.; Kobayashi, N.; Sugimura, K.; Qin, W.; Haxholli, D.; Chiba, Y.; Hayashi, G.; Onoda, H.; Ikegami, T.; Mulholland, C. B.; Nishiyama, A.; Nakanishi, M.; Leonhardt, H.; Konuma, T.; Arita, K.
10.1101/2022.06.14.496052 — biochemistry — Posted on 2022-06-14
2198 Population genomics provide insights into the global genetic structure of Colletotrichum graminicola, the causal agent of maize anthracnose
Rogerio, F.; Baroncelli, R.; Cuevas-Fernandez, F. B.; Becerra, S.; Crouch, J. A.; Bettiol, W.; Azcarate-Peril, M. A.; Malapi-Wight, M.; Ortega, V.; Betran, J.; Tenuta, A.; Dambolena, J. S.; Esker, P. D.; Revilla, P.; Jackson-Ziems, T.; Hiltbrunner, J.; Munkvold, G.; Buhinicek, I.; Vicente-Villardon, J. L.; Sukno, S. A.; Thon, M. R.
10.1101/2022.05.07.490914 — genomics — Posted on 2022-06-14
2201 Exploring the mosquito-arbovirus network: a survey of vector competence experiments
Chen, B.; Sweeny, A.; Wu, V. Y.; Christofferson, R. C.; Ebel, G.; Fagre, A. C.; Gallichotte, E.; Kading, R.; Ryan, S. J.; Carlson, C. J.
10.1101/2022.05.19.492743 — ecology — Posted on 2022-06-14
2203 Distinct airway progenitor cells drive epithelial heterogeneity in the developing human lung
Conchola, A. S.; Fum, T.; Xiao, Z.; Hsu, P. P.; Hein, R. F. C.; Miller, A. J.; Tsai, Y.-H.; Wu, A.; Kaur, K.; Holloway, E. M.; Anand, A.; Murthy, P. K. L.; Glass, I.; Tata, P. R.; Spence, J. R.
10.1101/2022.06.13.495813 — developmental biology — Posted on 2022-06-14
2205 Basis for antibody- and hormone-mediated activation of TSHR in Graves' disease
Duan, J.; Xu, P.; Luan, X.; Ji, Y.; Yuan, Q.; He, X.; Jin, Y.; Cheng, X.; Jiang, H.; Zhang, S.; Jiang, Y.; Xu, H. E.
10.1101/2022.06.13.496020 — molecular biology — Posted on 2022-06-14
2206 Attachment of the RNA degradosome to the inner cytoplasmic membrane of Escherichia coli prevents wasteful degradation of rRNA intermediates in ribosome assembly.
Hadjeras, L.; Bouvier, M.; Canal, I.; Poljak, L.; Morin-Ogier, Q.; Froment, C.; Burlet-Schlitz, O.; Hamouche, L.; Girbal, L.; Cocaign-Bousquet, M.; Carpousis, A. J.
10.1101/2022.06.14.496040 — molecular biology — Posted on 2022-06-14
2207 Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein
Byrne, P. J.; Fisher, B. E.; Ambrozak, D. R.; Blade, E. G.; Tsybovsky, Y.; Graham, B. S.; McLellan, J. S.; Loomis, R. J.
10.1101/2022.06.13.495706 — molecular biology — Posted on 2022-06-14
2210 A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
Ramaprasad, A.; Burda, P.-C.; Calvani, E.; Sait, A.; Palma-Duran, S. A.; Withers-Martinez, C.; Hackett, F.; MacRae, J. I.; Collinson, L.; Gilberger, T.; Blackman, M.
10.1101/2022.06.14.496138 — microbiology — Posted on 2022-06-14
2212 Nutrient limitation mimics artemisinin tolerance in malaria
Brown, A.; Warthan, M. D.; Aryal, A.; Liu, S.; Guler, J. L.
10.1101/2022.06.14.496121 — microbiology — Posted on 2022-06-14
2213 Investigating interspecific quorum sensing influence on cocoa fermentation quality through defined microbial cocktails
de Almeida, O. G. G.; Pereira, M. G.; Bighetti-Trevisan, R. L.; Santos, E. S.; De Campos, E. G.; Felis, G. E.; Guimaraes, L. H. S.; Polizeli, M. d. L. T. D. M.; De Martinis, B. S.; De Martinis, E. C. P.
10.1101/2022.06.14.496151 — microbiology — Posted on 2022-06-14
2214 Genetic mining of newly isolated Salmophages for phage therapy
Gendre, J.; Ansaldi, M.; Olivenza, D. R.; Denis, Y.; Casadesus, J.; Ginet, N.
10.1101/2022.06.14.493971 — microbiology — Posted on 2022-06-14
2215 Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas
Li, M.; Chen, C.; Wang, X.; Guo, P.; Feng, H.; Zhang, X.; Zhang, W.; Gu, C.; Zhu, J.; Wen, G.; Rao, V. B.; Tao, P.
10.1101/2022.06.13.495850 — immunology — Posted on 2022-06-14
2216 Protective efficacy of COVAXIN(R) against Delta and Omicron variants in hamster model
Yadav, P.; Mohandas, S.; Shete, A.; Sapkal, G.; Deshpande, G.; Kumar, A.; Wakchaure, K.; Dighe, H.; Jain, R.; Ganneru, B.; Yemul, J.; Gawande, P.; Vadrevu, K. M.; Abraham, P.
10.1101/2022.06.14.496021 — immunology — Posted on 2022-06-14
2217 Motor Learning Drives Dynamic Patterns of Intermittent Myelination onLearning-Activated Axons
Bacmeister, C. M.; Huang, R.; Osso, L. A.; Thornton, M. A.; Conant, L.; Chavez, A. R.; Poleg-Polsky, A. G.; Hughes, E. G.
10.1101/2021.10.13.464319 — neuroscience — Posted on 2022-06-14
2220 Functional network properties derived from widefield calcium imaging differ with wakefulness and across cell type
O'Connor, D.; Mandino, F.; Shen, X.; Horien, C.; Ge, X.; Herman, P.; Crair, M.; Papademetris, X.; Lake, E. M.; Constable, R. T.
10.1101/2022.05.24.493310 — neuroscience — Posted on 2022-06-14
2226 Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
Watson, J. A.; Pantier, R.; Jayachandran, U.; Chhatbar, K.; Alexander-Howden, B.; Kruusvee, V.; Prendecki, M.; Bird, A. P.; Cook, A. G.
10.1101/2022.06.14.495968 — biochemistry — Posted on 2022-06-14
2227 Crystal structure and functional peculiarities of a primordial Orange Carotenoid Protein (OCPX)
Slonimskiy, Y. B.; Zupnik, A. O.; Varfolomeeva, L. A.; Boyko, K. M.; Maksimov, E. G.; Sluchanko, N. N.
10.1101/2022.06.14.496144 — biochemistry — Posted on 2022-06-14
2228 Multifactorial chromatin regulatory landscapes at single cell resolution
Meers, M. P.; Llagas, G.; Janssens, D. H.; Codomo, C. A.; Henikoff, S.
10.1101/2021.07.08.451691 — genomics — Posted on 2022-06-14
2229 Illumina But With Nanopore: Sequencing Illumina libraries at high accuracy on the ONT MinION using R2C2
Zee, A.; Deng, D. Z. Q.; Adams, M.; Schimke, K. D.; Corbett-Detig, R.; Russell, S. L.; Zhang, X.; Schmitz, R. J.; Vollmers, C.
10.1101/2021.10.30.466545 — genomics — Posted on 2022-06-14
2230 Codon optimization, not gene content, predicts XYLose metabolism in budding yeasts
Nalabothu, R. L.; Fisher, K. J.; LaBella, A. L.; Meyer, T. A.; Opulente, D. A.; Wolters, J. F.; Rokas, A.; Hittinger, C. T.
10.1101/2022.06.10.495693 — evolutionary biology — Posted on 2022-06-14
2232 Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator
Knabl, P.; Schauer, A.; Pomreinke, A. P.; Zimmermann, B.; Rogers, K. W.; Mueller, P.; Genikhovich, G.
10.1101/2022.06.03.494682 — developmental biology — Posted on 2022-06-14
2234 Uracil/H+ symport by the FurE transporter challenges the rocking-bundle mechanism of transport in APC transporters
Zantza, I.; Papadaki, G. F.; Raniolo, S.; Pyrris, Y.; Lambrinidis, G.; Limongelli, V.; Diallinas, G.; Mikros, E.
10.1101/2022.03.28.486045 — molecular biology — Posted on 2022-06-14
2235 Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior protective humoral immune response to SARS-CoV-2
Taddeo, A.; Berenguer Veiga, I.; Devisme, C.; Boss, R.; Plattet, P.; Weigang, S.; Kochs, G.; Thiel, V.; Benarafa, C.; Zimmer, G.
10.1101/2022.06.14.495413 — immunology — Posted on 2022-06-14
2238 Precise modulation of transcription factor levels reveals drivers of dosage sensitivity
Naqvi, S.; Kim, S.; Hoskens, H.; Matthews, H.; Spritz, R. A.; Klein, O. D.; Hallgrimsson, B.; Swigut, T.; Claes, P.; Pritchard, J. K.; Wysocka, J.
10.1101/2022.06.13.495964 — genetics — Posted on 2022-06-14
2239 SARS-CoV-2 requires acidic pH to infect cells
Kreutzberger, A. J. B.; Sanyal, A.; Saminathan, A.; Bloyet, L.-M.; Stumpf, S.; Liu, Z.; Ojha, R.; Patjas, M. T.; Geneid, A.; Scanavachi, G.; Doyle, C. A.; Somerville, E.; Bango Da Cunha Correira, R.; Di Caprio, G.; Toppila-Salmi, S.; Makitie, A.; Kiessling, V.; Vapalahti, O.; Whelan, S. P. J.; Balistreri, G.; Kirchhausen, T.
10.1101/2022.06.09.495472 — microbiology — Posted on 2022-06-14
2241 Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Cardenas Canales, E. M.; Stockmaier, S.; Cronin, E.; Rocke, T.; Osorio, J. E.; Carter, G. G.
10.1101/2022.06.06.495012 — animal behavior and cognition — Posted on 2022-06-14
2242 A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan
Li, T. Y.; Gao, A. W.; Li, X.; Liu, Y. J.; Arey, R. N.; Morales, K.; Lalou, A.; Wang, Q.; Lima, T.; Auwerx, J.
10.1101/2022.06.13.495962 — cell biology — Posted on 2022-06-14
2245 Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery
Hermiston, T.; Hardy, J.; Bauzon, M.; Blankenberg, F. G.; Kanada, M.; Makela, A.; Chan, C. K. F.; Contag, C. H.
10.1101/2022.06.13.495901 — cell biology — Posted on 2022-06-14
2247 Condensin I folds the C. elegans genome
Das, M.; Semple, J. I.; Volodkina, V.; Haemmerli, A.; Scotton, J.; Gitchev, T.; Annan, A.; Statzer, C.; Ewald, C. Y.; Mozziconacci, J.; Campos, J.; Meister, P.
10.1101/2022.06.14.495661 — molecular biology — Posted on 2022-06-14
2248 BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Cao, Y. R.; Yisimayi, A.; Jian, F.; Song, W.; Xiao, T.; Wang, L.; Du, S.; Wang, J.; Li, Q.; Chen, X.; Yu, Y.; Wang, P.; Zhang, Z.; Liu, P.; An, R.; Hao, X.; Wang, Y.; Wang, J.; Feng, R.; Sun, H.; Zhao, L.; Zhang, W.; Zhao, D.; Zheng, J.; Yu, L.; Li, C.; Zhang, N.; Wang, R.; Niu, X.; Yang, S.; Song, X.; Chai, Y.; Hu, Y.; Shi, Y.; Zheng, L.; Li, Z.; Gu, Q.; Shao, F.; Huang, W.; Jin, R.; Shen, Z.; Wang, Y.; Wang, X.; Xiao, J.; Xie, X. S.
10.1101/2022.04.30.489997 — immunology — Posted on 2022-06-14
2249 Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles
Vettkoetter, D.; Schneider, M.; Liewald, J.; Zeiler, S.; Guldan, J.; Watanabe, S.; Gottschalk, A.
10.1101/2022.06.13.495966 — neuroscience — Posted on 2022-06-14
2251 Running modulates primate and rodent visual cortex via common mechanism but quantitatively distinct implementation
Liska, J. P.; Rowley, D. P.; Nguyen, T. T. K.; Muthmann, J.-O.; Butts, D. A.; Yates, J. L.; Huk, A. C.
10.1101/2022.06.13.495712 — neuroscience — Posted on 2022-06-14
2252 Thinking like a structural biologist: A pocket-based 3D molecule generative model fueled by electron density
Wang, L.; Bai, R.; Shi, X.; Zhang, W.; Cui, Y.; Wang, X.; Wang, C.; Chang, H.; Zhang, Y.; Zhou, J.; Peng, W.; Zhou, W.; Huang, B.
10.1101/2022.06.11.495756 — bioinformatics — Posted on 2022-06-14
2254 A genomic platform for epidemiological surveillance and vaccine antigen discovery using long-read amplicon sequencing
Plaza, D. F.; Zerebinski, J.; Broumou, I.; Lautenbach, M. J.; Ngasala, B.; Sundling, C.; Färnert, A.
10.1101/2022.06.08.495295 — genomics — Posted on 2022-06-14
2256 Spontaneous parthenogenesis in the parasitoid wasp Cotesia typhae: low frequency anomaly or evolving process?
Capdevielle Dulac, C.; Benoist, R.; Paquet, S.; Calatayud, P.-A.; Obonyo, J.; Kaiser, L.; Mougel, F.
10.1101/2021.12.13.472356 — evolutionary biology — Posted on 2022-06-14
2257 Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima
Arai, H.; Anbutsu, H.; Nishikawa, Y.; Kogawa, M.; Ishii, K.; Hosokawa, M.; Lin, S.-R.; Ueda, M.; Nakai, M.; Kunimi, Y.; Harumoto, T.; Kageyama, D.; Takeyama, H.; INOUE, M. N.
10.1101/2022.06.12.495854 — evolutionary biology — Posted on 2022-06-14
2258 Transient RNA structures cause aberrant influenza virus replication and innate immune activation
French, H.; Pitre, E.; Oade, M. S.; Elshina, E.; Bisht, K.; King, A.; Bauer, D. L. V.; te Velthuis, A. J. W.
10.1101/2022.01.25.476955 — microbiology — Posted on 2022-06-14
2259 A new Oprm1-Cre mouse line enables detailed molecular characterization of μ-opioid receptor cell types
Mengaziol, J.; Dunn, A. D.; Crues-Muncunill, J.; Eacret, D.; Chen, C.; Bland, K.; Liu-Chen, L.-Y.; Ehrlich, M. E.; Blendy, J. A.
10.1101/2022.06.09.495430 — neuroscience — Posted on 2022-06-14
2261 Subthalamic neural oscillations reveal no effect of implicit versus explicit facial emotional processing
Duprez, J.; Dondaine, T.; Houvenaghel, J.-F.; Modolo, J.; Haegelen, C.; Robert, G.; Millet, B.; Drapier, D.; Peron, J.; Grandjean, D.; Drapier, S.; Verin, M.; Sauleau, P.
10.1101/2020.10.21.348755 — neuroscience — Posted on 2022-06-14
2262 Neural mechanism of acute stress management by trace aminergic signalling in the lateral habenula
Yang, S. H.; Yang, E.; Lee, J.; Kim, J. Y.; Yoo, H.; Park, H. S.; Jung, J. T.; Lee, D.; Chun, S.; Lee, H. W.; Kim, H.
10.1101/2022.02.02.478114 — neuroscience — Posted on 2022-06-14
2263 Motor unit dysregulation following 15 days of unilateral lower limb immobilisation
Inns, T. B.; Bass, J. J.; Hardy, E. J. O.; Wilkinson, D. J.; Stashuk, D. W.; Atherton, P. J.; Phillips, B. E.; Piasecki, M.
10.1101/2022.06.01.494421 — physiology — Posted on 2022-06-14
2265 Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix
Galperin, E.; Norcross, R. G.; Abdelmoti, L.; Rouchka, E. C.; Andreeva, K.; Tussey, O.; Landestoy, D.
10.1101/2022.06.13.495941 — developmental biology — Posted on 2022-06-14
2267 Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Wagstyl, K.; Adler, S.; Seidlitz, J.; Vandekar, S.; Mallard, T. T.; Dear, R.; DeCasien, A. R.; Satterthwaite, T. T.; Liu, S.; Vertes, P. E.; Shinohara, R. T.; Alexander-Bloch, A.; Geschwind, D. H.; Raznahan, A.
10.1101/2022.06.13.495984 — neuroscience — Posted on 2022-06-14
2268 Juvenile Shank3 KO mice adopt distinct hunting strategies during prey capture learning
Kuhnle, C. G.; Grimes, M.; Casanova, V. M. S.; Turrigiano, G. G.; Van Hooser, S. D.
10.1101/2022.06.13.495982 — neuroscience — Posted on 2022-06-14
2270 Brain and Organoid Manifold Alignment (BOMA), a machine learning framework for comparative gene expression analysis across brains and organoids
He, C.; Kalafut, N. C.; Sandoval, S. O.; Risgaard, R.; Yang, C.; Khullar, S.; Suzuki, M.; Chang, Q.; Zhao, X.; Sousa, A. M. M.; Wang, D.
10.1101/2022.06.13.495946 — bioinformatics — Posted on 2022-06-14
2279 Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection
Mikaeloff, F.; Gelpi, M.; Benfeitas, R.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J.; Benfield, T.; Murray, D.; Giske, C. G.; Mardinoglu, A.; Troseid, M.; Poulsen, S. D.; Neogi, U.
10.1101/2022.06.08.495246 — bioinformatics — Posted on 2022-06-14
2282 Macroscale Adipose Tissue from Cellular Aggregates: A Simplified Method of Mass Producing Cell-Cultured Fat for Food Applications
Yuen, J. S.; Saad, M. K.; Xiang, N.; Barrick, B. M.; DiCindio, H.; Li, C.; Zhang, S. W.; Rittenberg, M.; Lew, E. T.; Leung, G.; Pietropinto, J. A.; Kaplan, D. L.
10.1101/2022.06.08.495192 — bioengineering — Posted on 2022-06-14
2284 Extracellular appendages govern spatial dynamics and growth of Caulobacter crescentus on a prevalent biopolymer
Povolo, V. R.; D'Souza, G. G.; Kaczmarczyk, A.; Stubbusch, A. K. M.; Jenal, U.; Ackermann, M.
10.1101/2022.06.13.495907 — microbiology — Posted on 2022-06-13
2285 Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale metabolic modeling.
Pavao, A.; Girinathan, B.; Peltier, J.; Silva, P. A.; Dupuy, B.; Muti, I.; Malloy, C.; Cheng, L.; Bry, L.
10.1101/2022.06.13.495811 — microbiology — Posted on 2022-06-13
2286 Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry
Priyamvada, L.; Kallemeijn, W. W.; Faronato, M.; Wilkins, K.; Goldsmith, C. S.; Cotter, C. A.; Ojeda, S.; Solari, R.; Moss, B.; Tate, E. W.; Satheshkumar, P. S.
10.1101/2022.06.13.495866 — microbiology — Posted on 2022-06-13
2287 Surface anchoring of the Kingella kingae galactan is dependent on the lipopolysaccharide O-antigen
Montoya, N. R.; Porsch, E. A.; Munoz, V. L.; Muszynski, A.; Vlach, J.; Hahn, D. K.; Azadi, P.; Sherman, M.; Yang, H.; Chandler, C. E.; Ernst, R. K.; St. Geme, J. W.
10.1101/2022.06.13.495970 — microbiology — Posted on 2022-06-13
2288 Computational Prediction of Synthetic Circuit Function Across Growth Conditions
Cummins, B.; Moseley, R. C.; Deckard, A.; Weston, M.; Zheng, G.; Bryce, D.; Nowak, J.; Gameiro, M.; Gedeon, T.; Mischaikow, K.; Beal, J.; Johnson, T.; Vaughn, M.; Gaffney, N. I.; Gopaulakrishnan, S.; Urrutia, J.; Goldman, R. P.; Bartley, B.; Nguyen, T. T.; Roehner, N.; Mitchell, T.; Vrana, J. D.; Clowers, K. J.; Maheshri, N.; Becker, D.; Mikhalev, E.; Biggers, V.; Higa, T.; Mosqueda, L.; Haase, S. B.
10.1101/2022.06.13.495701 — synthetic biology — Posted on 2022-06-13
2292 Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2
Bravo, J. P.; Hallmark, T.; Naegle, B.; Beisel, C. L.; Jackson, R. N.; Taylor, D. W.
10.1101/2022.06.13.495754 — biochemistry — Posted on 2022-06-13
2293 Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation
Jones, J. D.; Franco, M. K.; Smith, T. J.; Snyder, L. R.; Anders, A. G.; Ruotolo, B. T.; Kennedy, R. T.; Koutmou, K. S.
10.1101/2022.06.13.495843 — biochemistry — Posted on 2022-06-13
2294 Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter
Singh, I.; Seth, A.; Billesbolle, C. B.; Braz, J.; Rodriguiz, R. M.; Roy, K.; Bekele, B.; Craik, V.; Huang, X.-P.; Boytsov, D.; Lak, P.; O'Donnell, H. R.; Sandtner, W. R.; Roth, B. L.; Basbaum, A.; Wetsel, W. C.; Manglik, A.; Shoichet, B. K.; Rudnick, G.
10.1101/2022.06.13.495991 — biochemistry — Posted on 2022-06-13
2295 Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima
Arai, H.; Anbutsu, H.; Nishikawa, Y.; Kogawa, M.; Ishii, K.; Hosokawa, M.; Lin, S.-R.; Ueda, M.; Nakai, M.; Kunimi, Y.; Harumoto, T.; Kageyama, D.; Takeyama, H.; INOUE, M. N.
10.1101/2022.06.12.495854 — evolutionary biology — Posted on 2022-06-13
2297 Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA
Dmytrenko, O.; Neumann, G.; Hallmark, T.; Keiser, D. J.; Crowley, V. M.; Vialetto, E.; Mougiakos, I.; Wandera, K. G.; Domgaard, H.; Weber, J.; Metcalf, J.; Begemann, M. B.; Gray, B. N.; Jackson, R. N.; Beisel, C. L.
10.1101/2022.06.13.495973 — microbiology — Posted on 2022-06-13
2298 Dynamic structural adaptations enable the endobiotic predation of bdellovibrio bacteriovorus
Kaplan, M.; Chang, Y.-W.; Oikonomou, C. M.; Nicolas, W. J.; Jewett, A. I.; Kreida, S.; Dutka, P.; Rettberg, L. A.; Maggi, S.; Jensen, G. J.
10.1101/2022.06.13.496000 — microbiology — Posted on 2022-06-13
2300 The soybean rust pathogen Phakopsora pachyrhizi displays transposable element proliferation that correlates with broad host-range adaptation on legumes
Gupta, Y. K.; Marcelino-Guimaraes, F. C.; Lorrain, C.; Farmer, A. D.; Haridas, S.; Ferreira, E. G. C.; Lopes-Caitar, V. S.; Oliveira, L. S.; Morin, E.; Widdison, S.; Cameron, C.; Innoue, Y.; Thor, K.; Robinson, K.; Drula, E.; Henrissat, B.; LaButti, K.; Bini, A. M. R.; Paget, E.; Singan, V.; Daum, C.; Dorme, C.; van Hoek, M.; Janssen, A.; Chandat, L.; Tarriotte, Y.; Richardson, J.; Melo, B. d. V. A.; Wittenberg, A.; Schneiders, H.; Peyrard, S.; Zanardo, L. G.; Holtman, V. C.; Chauvel, F. C.; Link, T. I.; Balmer, D.; Müller, A. N.; Kind, S.; Bohnert, S.; Wirtz, L.; Chen, C.; Yan, M.; Ng, V.; G
10.1101/2022.06.13.495685 — microbiology — Posted on 2022-06-13
2302 Structure of SARS-CoV-2 M protein in lipid nanodiscs
Dolan, K. A.; Dutta, M.; Kern, D. M.; Kotecha, A.; Voth, G. A.; Brohawn, S. G.
10.1101/2022.06.12.495841 — biophysics — Posted on 2022-06-13
2304 SARS2Mutant: SARS-CoV-2 Amino-Acid Mutation Atlas Database
Rahimian, K.; Mahmanzar, M.; Mahdavi, B.; Arefian, E.; Kuehu, D. L.; Deng, Y.
10.1101/2022.06.12.495856 — bioinformatics — Posted on 2022-06-13
2307 An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants
Ishigaki, H.; Yasui, F.; Nakayama, M.; Endo, A.; Yamamoto, N.; Yamaji, K.; Nguyen, C. T.; Kitagawa, Y.; Sanada, T.; Honda, T.; Munakata, T.; Higa, M.; Toyama, S.; Kono, R.; Takagi, A.; Matsumoto, Y.; Hayashi, K.; Shiohara, M.; Ishii, K.; Saeki, Y.; Itoh, Y.; Kohara, M.
10.1101/2022.06.12.495779 — microbiology — Posted on 2022-06-13
2313 A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
PAL, S.; Kaplan, J. P.; Nguyen, H.; Stopka, S. A.; Savani, M. R.; Regan, M. S.; Nguyen, Q.-D.; Jones, K. L.; Moreau, L. A.; Peng, J.; Dipiazza, M. G.; Perciaccante, A.; Zhu, X.; Hunsel, B.; Liu, K. X.; Drissi, R.; Filbin, M. G.; McBrayer, S. K.; Agar, N.; Chowdhury, D.; Haas-Kogan, D.
10.1101/2021.11.30.470644 — cancer biology — Posted on 2022-06-13
2315 Processing UMI Datasets at High Accuracy and Efficiency with the Sentieon ctDNA Analysis Pipeline
Hu, J.; Jiang, C.; Huang, Y. S.; Chen, H.; Feng, H.; Freed, D.; Qu, Y.; Fan, R.; Su, Z.; Chen, W.
10.1101/2022.06.03.494742 — bioinformatics — Posted on 2022-06-13
2317 Comparison of R9.4.1/Kit10 and R10/Kit12 Oxford Nanopore flowcells and chemistries in bacterial genome reconstruction
Sanderson, N. D.; Kapel, N.; Rodger, G.; Webster, H.; Lipworth, S.; Street, T. L.; Peto, T. E.; Crook, D. W.; Stoesser, N.
10.1101/2022.04.29.490057 — genomics — Posted on 2022-06-13
2318 KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome
Yu, Z.; Zhou, X.; Liu, Z.; Pastrana-Gomez, V.; Liu, Y.; Guo, M.; Tian, L.; Nelson, T. J.; Wang, N.; Mital, S.; Chitayat, D.; Wu, J. C.; Rabinovitch, M.; Wu, S. M.; Snyder, M. P.; Miao, Y.; Gu, M.
10.1101/2021.08.30.457716 — developmental biology — Posted on 2022-06-13
2319 Neural plate progenitors give rise to both anterior and posterior pituitary cells
Chen, Q.; Leshkowitz, D.; Li, H.; van Impel, A.; Schulte-Merker, S.; Amit, I.; Levkowitz, G.
10.1101/2022.06.12.495791 — developmental biology — Posted on 2022-06-13
2320 The special and general mechanism of cyanobacterial harmful algal blooms
Cheng, W.; Hwang, S.; Guo, Q.; Qian, L.; Liu, W.; Yu, Y.; Li, Z.; Wang, T.; Tao, Y.; Cao, H.
10.1101/2021.11.22.469516 — microbiology — Posted on 2022-06-13
2321 Transcriptome network analysis of human CD1c+ dendritic cells identifies an inflammatory cytokine-secreting subpopulation within the CD14+ DC3s that accumulates locally in type I IFN-negative autoimmunity to the eye
Hiddingh, S.; Pandit, A.; Verhagen, F.; Rijken, R.; Servaas, N.; Komer-Wichers, R.; Dam-van Loon, N. t.; Imhof, S. S.; Radstake, T.; de Boer, J. H.; Kuiper, J. J. W.
10.1101/2021.11.16.468816 — immunology — Posted on 2022-06-13
2322 Development of neonatal brain functional centrality and alterations associated with preterm birth
Fenn-Moltu, S.; Fitzgibbon, S. P.; Ciarrusta, J.; Eyre, M.; Cordero-Grande, L.; Chew, A.; Falconer, S.; Gale-Grant, O.; Harper, N.; Dimitrova, R.; Vecchiato, K.; Fenchel, D.; Javed, A.; Earl, M.; Price, A.; Hughes, E.; Duff, E.; O'Muircheartaigh, J.; Nosarti, C.; Arichi, T.; Rueckert, D.; Counsell, S.; Hajnal, J. V.; Edwards, A. D.; McAlonan, G.; Batalle, D.
10.1101/2022.06.01.494304 — neuroscience — Posted on 2022-06-13
2329 Microfluidics-free single-cell genomics with templated emulsification
Clark, I. C.; Fontanez, K. M.; Meltzer, R. H.; Xue, Y.; Hayford, C.; May-Zhang, A.; D'Amato, C.; Osman, A.; Zhang, J. Q.; Hettige, P.; Delley, C. L.; Weisgerber, D. W.; Replogle, J. M.; Jost, M.; Phong, K. T.; Kennedy, V. E.; Peretz, C. A. C.; Kim, E. A.; Song, S.; Karlon, W.; Weissman, J. S.; Smith, C. C.; Gartner, Z. J.; Abate, A.
10.1101/2022.06.10.495582 — genomics — Posted on 2022-06-13
2331 The adipose-neural axis is critically involved in cardiac arrhythmias
Fan, Y.; Huang, S.; Li, S.; Wu, B.; Huang, L.; Zhao, Q.; Zheng, Z.; Xie, X.; Liu, J.; Huang, W.; Sun, J.; Zhu, X.; Wang, M.; Zhang, J.; Xiang, A. P.; Li, W. Y.
10.1101/2022.06.12.495845 — cell biology — Posted on 2022-06-13
2335 Death-associated protein kinase 3 (DAPK3) regulates the myogenic reactivity of cerebral arterioles
Turner, S. R.; Carlson, D. A.; Chappellaz, M.; Sutherland, C.; Haystead, T. A.; Cole, W. C.; MacDonald, J. A.
10.1101/2022.06.10.495652 — physiology — Posted on 2022-06-13
2336 Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins
Pesce, F.; Newcombe, E. A.; Seiffert, P.; Tranchant, E. E.; Olsen, J. G.; Kragelund, B. B.; Lindorff-Larsen, K.
10.1101/2022.06.11.495732 — biophysics — Posted on 2022-06-13
2337 Live cell nanodot arrays uncover synergistic co-condensation of Wnt signalodroplets
Philippi, M.; Richter, C. P.; Kappen, M.; Watrinet, I.; Miao, Y.; Runge, M.; Jorde, L.; Korneev, S.; Holtmannspoetter, M.; Kurre, R.; Holthuis, J.; Garcia, K. C.; Plueckthun, A.; Steinhart, M.; Piehler, J.; You, C.
10.1101/2022.06.11.495600 — biophysics — Posted on 2022-06-13
2338 Bento: A toolkit for subcellular analysis of spatial transcriptomics data
Mah, C. K.; Ahmed, N.; Lam, D.; Monell, A.; Kern, C.; Han, Y.; Cesnik, A. J.; Lundberg, E.; Zhu, Q.; Carter, H. W.; Yeo, G. W.
10.1101/2022.06.10.495510 — bioinformatics — Posted on 2022-06-13
2340 Distinguishing discrete and continuous behavioral variability using warped autoregressive HMMs
Costacurta, J. C.; Duncker, L.; Sheffer, B.; Williams, A. H.; Gillis, W.; Weinreb, C.; Markowitz, J. E.; Datta, S. R.; Linderman, S. W.
10.1101/2022.06.10.495690 — animal behavior and cognition — Posted on 2022-06-13
2342 Formal Recognition and Classification of Gene Transfer Agents as Viriforms
Kogay, R.; Koppenhofer, S.; Beatty, J. T.; Lang, A. S.; Kuhn, J. H.; Zhaxybayeva, O.
10.1101/2022.06.10.494566 — evolutionary biology — Posted on 2022-06-13
2343 Water-Quality analysis and Fish diversity of Southern West Part of the West-Bengal
Chini, D. S.; Mondal, N.; Kar, A.; Bunholi, I. V.; Singh, S.; Ghosh, P.; Patra, P.; Patra, S.; Patra, B. C.
10.1101/2022.06.11.495752 — ecology — Posted on 2022-06-13
2344 Hydrodynamics shapes self-recruitment in anemonefishes
Sato, M.; Honda, K.; Nakamura, Y.; Bernardo, L. P. C.; Bolisay, K. O.; Yamamoto, T.; Herrera, E. C.; Nakajima, Y.; Lian, C.; Uy, W. H.; Fortes, M. D.; Nadaoka, K.; Nakaoka, M.
10.1101/2022.06.11.495394 — ecology — Posted on 2022-06-13
2346 Cell Wall Dynamics in a Filamentous Fungus
Chevalier, L.; Pinar, M.; Le Borgne, R.; Durieu, C.; Penalva, M.; Boudaoud, A.; MINC, N.
10.1101/2022.06.12.495826 — cell biology — Posted on 2022-06-13
2347 Nanog organizes transcription bodies
Kuznetsova, K.; Ugolini, M.; Wu, E.; Lalit, M.; Oda, H.; Sato, Y.; Kimura, H.; Jug, F.; Vastenhouw, N.
10.1101/2022.06.13.495463 — cell biology — Posted on 2022-06-13
2351 Mutation of the Drosophila serotonin transporter dSERT disrupts courtship and feeding and increases both daytime and nighttime sleep
Krantz, D. E.; Knapp, E. M.; Kaiser, A.; Arnold, R. C.; Sampson, M. M.; Ruppert, M.; Xu, L.; Anderson, M. I.; Bonanno, S. L.; Scholz, H.; Donlea, J. M.
10.1101/2022.06.10.495593 — neuroscience — Posted on 2022-06-13
2355 Single cell transcriptomics reveals functionally specialized vascular endothelium in brain
Jeong, H.-W.; Dieguez-Hurtado, R.; Arf, H.; Song, J.; Park, H.; Kruse, K.; Sorokin, L.; Adams, R. H.
10.1101/2022.06.10.495613 — physiology — Posted on 2022-06-13
2356 How long can tardigrades survive in anhydrobiotic state? Searching on tardigrade anhydrobiosis patterns
Kaczmarek, Łukasz; Roszkowska, M.; Gołdyn, B.; Wojciechowska, D.; Ksiezkiewicz, Z.; Fiałkowska, E.; Pluskota, M.; Kmita, H.
10.1101/2022.06.10.495611 — physiology — Posted on 2022-06-13
2360 Thinking like a structural biologist: A pocket-based 3D molecule generative model fueled by electron density
Wang, L.; Bai, R.; Shi, X.; Zhang, W.; Cui, Y.; Wang, X.; Wang, C.; Chang, H.; zhang, y.; Zhou, J.; Zhou, W.; Huang, B.
10.1101/2022.06.11.495756 — bioinformatics — Posted on 2022-06-13
2362 MetaboDirect: An Analytical Pipeline for the processing of FTICR-MS-based Metabolomics Data
Ayala-Ortiz, C. O.; Graf-Grachet, N.; Freire-Zapata, V.; Fudyma, J.; Hildebrand, G.; AminiTabrizi, R.; Howard-Varona, C.; Corilo, Y. E.; Hess, N.; Duhaime, M. B. O.; Sullivan, M. B.; Tfaily, M.
10.1101/2022.06.10.495699 — bioinformatics — Posted on 2022-06-13
2363 Increasing the Field-of-View in Oblique Plane Microscopy via optical tiling
Chen, B.; Chang, B.-J.; Zhou, F.; Daetwyler, S.; Sapoznik, E.; Gihana, G. M.; Castro, L. P.; Conacci-Sorrell, M.; Dean, K. M.; Millett-Sikking, A.; York, A.; Fiolka, R. P.
10.1101/2022.06.12.495844 — bioengineering — Posted on 2022-06-13
2365 Pan-genome inversion index reveals evolutionary insights into the subpopulation structure of Asian rice (Oryza sativa)
Zhou, Y.; Yu, Z.; Chebotarov, D.; Chougule, K.; Lu, Z.; Rivera, L.; Kathiresan, N.; Al-Bader, N.; Mohammed, N.; Alsantely, A.; Mussurova, S.; Santos, J.; Thimma, M.; Troukhan, M.; Fornasiero, A.; Green, C.; Copetti, D.; Kudrna, D.; Llaca, V.; Lorieux, M.; Zuccolo, A.; Ware, D.; McNally, K.; Zhang, J.; Wing, R.
10.1101/2022.06.11.495682 — genomics — Posted on 2022-06-13
2366 Codon optimization, not gene content, predicts XYLose metabolism in budding yeasts
Nalabothu, R. L.; Fisher, K. J.; LaBella, A. L.; Meyer, T. A.; Opulente, D. A.; Wolters, J. F.; Rokas, A.; Hittinger, C. T.
10.1101/2022.06.10.495693 — evolutionary biology — Posted on 2022-06-13
2367 Sturgeons: An Evolutionary Insight to The α-globin Protein Speciation and Diversification
Ariaeenejad, S.; Kavousi, K.; Elahi, E.; Banaei-Moghaddam, A. M.; Moosavi-Movahedi, A. A.
10.1101/2022.06.11.495750 — evolutionary biology — Posted on 2022-06-13
2368 Complex multiple introductions drive fall armyworm invasions into Asia and Australia
Rane, R.; Walsh, T.; Lenancker, P.; Gock, A.; Hang, D. T.; Liem, N. V.; Khin, T. N.; Amalin, D.; Chittarath, K.; Faheem, M.; Sivapragasam, A.; Thanarajoo, S. S.; Trisyono, Y. A.; Khay, S.; Kim, J.; Kuniata, L.; Powell, K.; Kalyebi, A.; Otim, M.; Gordon, K.; Tay, W. T.
10.1101/2022.06.11.495773 — evolutionary biology — Posted on 2022-06-13
2371 Reconstruction of visual images from mouse retinal ganglion cell spiking activity using convolutional neural networks
Benster, T.; Babino, D.; Thickstun, J.; Hunt, M.; Liu, X.; Harchaoui, Z.; Oh, S.; Van Gelder, R. N.
10.1101/2022.06.10.482188 — neuroscience — Posted on 2022-06-13
2375 Differential D1 and D2 receptor internalization and recycling induced by amphetamine in vivo
Hansen, H. D.; Schain, M.; Deng, H. P.; Mandeville, J. B.; Rosen, B. R.; Sander, C. Y.
10.1101/2022.06.10.493955 — neuroscience — Posted on 2022-06-13
2376 Cell types and molecular architecture of the octopus visual system
Songco-Casey, J. O.; Coffing, G. C.; Piscopo, D. M.; Pungor, J. R.; Kern, A. D.; Miller, A. C.; Niell, C. M.
10.1101/2022.06.11.495763 — neuroscience — Posted on 2022-06-13
2378 Off-manifold coding in visual cortex revealed by sleep
de Oliveira, E. F.; Kim, S.; Qiu, T. S.; Peyrache, A.; Batista-Brito, R.; Sjulson, L.
10.1101/2022.06.10.495710 — neuroscience — Posted on 2022-06-13
2383 Gli1+ mesenchymal progenitors contribute to multilineage differentiation in a mouse model of post-traumatic joint injury
Magallanes, J.; Liu, N. Q.; Zhang, J.; Ouyang, Y.; Mkaratigwa, T.; Bian, F.; Van Handel, B.; Skorka, T.; Petrigliano, F. A.; Evseenko, D.
10.1101/2022.06.11.495765 — pathology — Posted on 2022-06-13
2390 Whole genome sequencing of a wild yam species Dioscorea tokoro reveals a genomic region associated with sex
Natsume, S.; Yaegashi, H.; Sugihara, Y.; Abe, A.; Shimizu, M.; Oikawa, K.; White, B.; Kudoh, A.; Terauchi, R.
10.1101/2022.06.11.495741 — plant biology — Posted on 2022-06-13
2392 Noise-mediated self-organization in mutually shading sunflowers
Nguyen, C.; Dromi, I.; Kempinski, A.; Gall, G. E. C.; Peleg, O.; Meroz, Y.
10.1101/2022.06.11.495747 — plant biology — Posted on 2022-06-13
2393 The Role of UBE2-Conjugating Enzymes in the Mechanism of MuRF1 Ubiquitylation
Dawson, P. W. J.; Baehr, L. M.; Hughes, D. C.; Knowles, T. J.; Sridhar, P.; Bodine, S. C.; Lai, Y.-C.
10.1101/2022.06.13.495268 — molecular biology — Posted on 2022-06-13
2395 Comparative multi-omic analyses reveal gene regulatory networks controlling physiological and metabolic responses to drought in upland cotton
Yu, L.; Nelson Dittrich, A. C.; Melandri, G.; Skirycz, A.; Thorp, K. R.; Hinze, L. L.; Nelson, A. D. L.; Pauli, D.
10.1101/2022.06.10.495687 — plant biology — Posted on 2022-06-13
2396 Extinction cascades, community collapse, and recovery across a Mesozoic hyperthermal event
Dunhill, A. M.; Zarzyczny, K.; Shaw, J. O.; Atkinson, J. W.; Little, C. T. S.; Beckerman, A. P.
10.1101/2022.06.13.495894 — paleontology — Posted on 2022-06-13
2397 A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development
Ponomarova, O.; Zhang, H.; Li, X.; Nanda, S.; Leland, T. B.; Fox, B. W.; Giese, G. E.; Schroeder, F. C.; Yilmaz, S. L.; Walhout, A. J. M.
10.1101/2022.05.16.492161 — biochemistry — Posted on 2022-06-13
2402 High overexploitation risk and management shortfall in highly traded requiem sharks
Sherman, C. S.; Digel, E. D.; Zubick, P.; Eged, J.; Haque, A. B.; Matsushiba, J. H.; Simpfendorfer, C. A.; Sant, G.; Dulvy, N. K.
10.1101/2022.06.09.495558 — ecology — Posted on 2022-06-13
2403 A Development-Inspired Niche for Homeostatic Human Mini-Intestines
Childs, C. J.; Holloway, E. M.; Sweet, C. W.; Tsai, Y.-H.; Wu, A.; Wu, J. H.; Cardenas, O. P.; Capeling, M. M.; Eiken, M.; Zwick, R.; Palikuqi, B.; Trentesaux, C.; Zhang, C.; Glass, I.; Loebel, C.; Yu, Q.; Camp, G.; Sexton, J. Z.; Klein, O. D.; Verzi, M. P.; Spence, J. R.
10.1101/2022.06.12.495827 — developmental biology — Posted on 2022-06-13
2404 Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Al Jord, A.; Letort, G.; Chanet, S.; Tsai, F.-C.; Antoniewski, C.; Eichmuller, A.; Da Silva, C.; HUYNH, J.-R.; Gov, N.; Voituriez, R.; Terret, M.-E.; Verlhac, M.-H.
10.1101/2021.03.15.434387 — cell biology — Posted on 2022-06-13
2405 Loss of the protein disrupted in schizophrenia 1 (DISC1) impairs cardiac resistance against ischemia.
Gurdeep Marwahra, G.; Pinho, M. J.; Slagsvold, K. H.; Wahba, A.; Rosbjorgen, R. E.; Enguita, F. J.; Yang, K.; Ishizuka, K.; Casas, C. A. A.; Pettersen, K.; Bjorkoy, G.; Sawa, A.; Hoydal, M. A.
10.1101/2022.06.09.494639 — molecular biology — Posted on 2022-06-13
2407 Marker-free coselection for successive rounds of prime editing in human cells
Levesque, S.; Mayorga, D.; Fiset, J.-P.; Goupil, C.; Duringer, A.; Loiselle, A.; Bouchard, E.; Agudelo, D.; Doyon, Y.
10.1101/2021.11.02.464583 — molecular biology — Posted on 2022-06-13
2408 SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells
Nguyen, L. C.; Renner, D. M.; Silva, D.; Yang, D.; Parenti, N.; Medina, K. M.; Nicolaescu, V.; Gula, H.; Drayman, N.; Valdespino, A.; Mohamed, A.; Dann, C.; Wannemo, K.; Robinson-Mailman, L.; Gonzalez, A.; Stock, L.; Cao, M.; Qiao, Z.; Moellering, R. E.; Tay, S.; Randall, G.; Beers, M. F.; Rosner, M. R.; Oakes, S. A.; Weiss, S. R.
10.1101/2021.12.30.474519 — microbiology — Posted on 2022-06-13
2409 Botrytis cinerea identifies host plants via the recognition of antifungal capsidiol to induce expression of a specific detoxification gene
Kuroyanagi, T.; Bulasag, A.; Fukushima, K.; Suzuki, T.; Tanaka, A.; Camagna, M.; Sato, I.; Chiba, S.; Ojika, M.; Takemoto, D.
10.1101/2022.05.11.490027 — microbiology — Posted on 2022-06-13
2412 Intact Drosophila Central Nervous System Cellular Quantitation reveals Sexual Dimorphism
Jiao, W.; Spreemann, G.; Ruchti, E.; Banerjee, S.; Vernon, S.; Shi, Y.; Stowers, R. S.; Hess, K.; McCabe, B. D.
10.1101/2021.11.03.467146 — neuroscience — Posted on 2022-06-13
2414 RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections
Lace, B.; Su, C.; Invernot Perez, D.; Rodriguez-Franco, M.; Vernie, T.; Batzenschlager, M.; Egli, S.; Liu, C.-W.; Ott, T.
10.1101/2022.06.03.494689 — plant biology — Posted on 2022-06-13
2415 In situ architecture and membrane fusion of SARS-CoV-2 Delta variant
Song, Y.; Yao, H.; Wu, N.; Xu, J.; Zhang, Z.; Peng, C.; Li, S.; Kong, W.; Chen, Y.; Zhu, M.; Wang, J.; Shi, D.; Zhao, C.; Lu, X.; Echavarria Galindo, M.; Li, S.
10.1101/2022.05.13.491759 — biophysics — Posted on 2022-06-13
2417 Reducing CRISPR dark matter reveals a strong association between the bacterial membranome and CRISPR-Cas systems
Rubio, A.; Sprang, M.; Garzon, A.; Pachon-Ibanez, M. E.; Pachon, J.; Andrade-Navarro, M. A.; Perez-Pulido, A. J.
10.1101/2022.04.26.489349 — bioinformatics — Posted on 2022-06-13
2422 SARS-CoV-2 type I Interferon modulation by non structural proteins 1 and 2
Flamand, L.; Lacasse, E.; Dubuc, I.; Allaeys, I.; Gudimard, L.; Gravel, A.; Boilard, E.
10.1101/2022.06.09.495586 — microbiology — Posted on 2022-06-13
2424 Human norovirus efficiently replicates in differentiated 3D-human intestinal enteroids
Mirabelli, C.; Santos-Ferreira, N.; Gillilland, M. G.; Cieza, R. J.; Colacino, J.; Sexton, J. Z.; Taube, S.; Rocha-Pereira, J.; Wobus, C. E.
10.1101/2022.06.09.495585 — microbiology — Posted on 2022-06-13
2425 Adjuvants influence the maturation of VRC01-like antibodies during immunization
Kudsen, M. L.; Agrawal, P.; MacCamy, A.; Parks, R. K.; Gray, M. D.; Takushi, B.; Khechaduri, A.; Coler, R.; LaBranche, C.; Montefiori, D.; Stamatatos, L.
10.1101/2022.06.10.495681 — immunology — Posted on 2022-06-13
2426 Microglia shape the embryonic development of mammalian respiratory networks
Cabirol, M.-J.; Cardoit, L.; Courtand, G.; Mayeur, M.-E.; Simmers, J.; Pascual, O.; Thoby-Brisson, M.
10.1101/2022.06.08.495245 — neuroscience — Posted on 2022-06-13
2428 Network-based multi-omics integration reveals metabolic risk profile within treated HIV-infection
Mikaeloff, F.; Gelpi, M.; Benfeitas, R.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J.; Benfield, T.; Murray, D.; Giske, C. G.; Mardinoglu, A.; Troseid, M.; Poulsen, S. D.; Neogi, U.
10.1101/2022.06.08.495246 — bioinformatics — Posted on 2022-06-13
2431 Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility
Velasco, I.; Franssen, D.; Daza-Duenas, S.; Skrapits, K.; Takacs, S.; Torres, E.; Rodriguez-Vazquez, E.; Ruiz-Cruz, M.; Leon, S.; Kukoricza, K.; Zhang, F.-P.; Ruohonen, S.; Luque-Cordoba, D.; Priego-Capote, F.; Gaytan, F.; Ruiz-Pino, F.; Hrabovszky, E.; Poutanen, M.; Vazquez, M. J.; Tena-Sempere, M.
10.1101/2022.06.07.495233 — physiology — Posted on 2022-06-12
2433 Recording and Manipulation of the Maternal Oxytocin Neural Activities in Mice
Yukinaga, H.; Hagihara, M.; Tsujimoto, K.; Chiang, H.-L.; Kato, S.; Kobayashi, K.; Miyamichi, K.
10.1101/2021.07.26.453888 — neuroscience — Posted on 2022-06-12
2434 Structural bases for blockade and activation of BK channels by Ba2+ ions
Srivastava, S.; Miranda Fernandez, P.; de Val, N.; Giraldez, T.; Zhu, J.; Cachau, R. E.; Holmgren, M.
10.1101/2022.06.10.495656 — biophysics — Posted on 2022-06-12
2437 Fungi with history: Unveiling the mycobiota of historic documents of Costa Rica
Escudero-Leyva, E.; Vieto, S.; Avendano, R.; Rojas-Gätjens, D.; Agüero, P.; Pacheco, C.; Montero, M. L.; Chaverri, P.; Chavarria, M.
10.1101/2022.06.12.495835 — microbiology — Posted on 2022-06-12
2438 Enhancing associative learning in rats with a computationally designed training protocol
Zhang, X. O.; Zhang, Y.; Engelke, D. S.; Cho, C. E.; Smolen, P.; Byrne, J. H.; Do Monte, F. H.
10.1101/2022.06.08.495364 — neuroscience — Posted on 2022-06-12
2443 Mnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric t(7;12) Acute Myeloid Leukemia.
Waraky, A.; Ostlund, A.; Nilsson, T.; Weichenhan, D.; Lutsik, P.; Baehr, M.; Hey, J.; Adamsson, J.; Morsy, M. H. A.; Li, S.; Fogelstrand, L.; Plass, C.; Palmqvist, L.
10.1101/2022.06.10.495634 — cancer biology — Posted on 2022-06-12
2444 Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography
Wolff, A. M.; Nango, E.; Young, I. D.; Brewster, A. S.; Kubo, M.; Nomura, T.; Sugahara, M.; Owada, S.; Barad, B. A.; Ito, K.; Bhowmick, A.; Carbajo, S.; Hino, T.; Holton, J. M.; Im, D.; O'Riordan, L. J.; Tanaka, T.; Tanaka, R.; Sierra, R. G.; Yumoto, F.; Tono, K.; Iwata, S.; Sauter, N. K.; Fraser, J. S.; Thompson, M. C.
10.1101/2022.06.10.495662 — biophysics — Posted on 2022-06-12
2446 A Development-Inspired Niche for Homeostatic Human Mini-Intestines
Childs, C. J.; Holloway, E. M.; Sweet, C. W.; Tsai, Y.-H.; Wu, A.; Wu, J.; Cardenas, O. P.; Capeling, M. M.; Eiken, M.; Zwick, R.; Palikuqi, B.; Trentesaux, C.; Zhang, C.; Glass, I.; Loebel, C.; Yu, Q.; Camp, G.; Sexton, J. Z.; Klein, O. D.; Verzi, M. P.; Spence, J. J.
10.1101/2022.06.12.495827 — developmental biology — Posted on 2022-06-12
2447 Hybrid immunity shifts the Fc-effector quality of SARS-CoV-2 mRNA vaccine-induced immunity
Bowman, K. A.; Stein, D.; Shin, S.; Ferbas, K. G.; Tobin, N.; Mann, C.; Fischinger, S.; Ollmann Saphire, E.; Lauffenberger, D.; Rimoin, A.; Aldrovandi, G.; Alter, G.
10.1101/2022.06.10.495727 — immunology — Posted on 2022-06-11
2448 Exogenous Nav1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet
Fadila, S.; Beucher, B.; Dopeso-Reyes, I. G.; Mavashov, A.; Brusel, M.; Anderson, K.; Goldberg, E. M.; Ricobaraza, A.; Hernandez-Alcoceba, R.; Kremer, E. J.; Rubinstein, M.
10.1101/2022.06.10.495591 — neuroscience — Posted on 2022-06-12
2449 MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
Kilian, M.; Sheinin, R.; Tan, C. L.; Kraemer, C.; Friedrich, M.; Kaminitz, A.; Sanghvi, K.; Lindner, K.; Cichon, F.; Jung, S.; Jaehne, K.; Ratliff, M.; Prins, R.; von Deimling, A.; Wick, W.; Madi, A.; Bunse, L.; Platten, M.
10.1101/2022.06.10.495502 — cancer biology — Posted on 2022-06-12
2450 β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression
Suzuki, T.; Kilbey, A.; Ridgway, R. A.; Hayman, H.; Byrne, R.; Casa Rodriguez, N.; Georgakopoulou, A.; Chen, L.; Verzi, M.; Gay, D. M.; Vzquez, E. G.; Belnoue-Davis, H. L.; Gilroy, K.; Kostner, A. H.; Kersten, C.; Thuwajit, C.; Andersen, D.; Wiesheu, R.; Jandke, A.; Roberts, N.; Blyth, K.; Roseweir, A.; Leedham, S. J.; Dunne, P. D.; Edwards, J.; Hayday, A.; Sansom, O. J.; Coffelt, S. B.
10.1101/2022.06.10.495115 — cancer biology — Posted on 2022-06-12
2451 Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance
Carney, S. V.; Banerjee, K.; Mujeeb, A.; Zhu, B.; Haase, S.; Varela, M. L.; Kadiyala, P.; Tronrud, C.; Zhu, Z.; Mukherji, D.; Gorla, P.; Tagett, R.; Nunez, F. J.; Luo, M.; Lou, W.; Ljungman, M.; Liu, Y.; Xia, Z.; Schwendeman, A.; Qin, T.; Sartor, M. A.; Costello, J.; Cahill, D. P.; Lowenstein, P. R.; Castro, M. G.
10.1101/2022.06.10.495694 — cancer biology — Posted on 2022-06-12
2453 Optical Control Of Neuronal Activities With Photoswitchable Nanovesicles
Xiong, H.; Alberto, K. A.; Youn, J.; Taura, J.; Morstein, J.; Li, X.; Wang, Y.; Trauner, D.; Slesinger, P. A.; Nielsen, S. O.; Qin, Z.
10.1101/2022.06.10.495373 — bioengineering — Posted on 2022-06-12
2454 Preclinical assessment of Fibroblast Activation Protein-specific MRI as an alternative to PSMA for image-guided focal therapy of prostate cancer
Dmochowska, N.; Milanova, V.; Mukkamala, R.; Pham, N. T.; Srinivasarao, M.; Ebert, L. M.; Stait-Gardner, T.; Le, H.; Shetty, A.; Low, P. S.; Thierry, B.
10.1101/2022.06.10.495719 — bioengineering — Posted on 2022-06-12
2455 Genome-wide association and genomic prediction of growth traits in the European flat oyster (Ostrea edulis)
Penaloza, C.; Barria, A.; Papadopoulou, A.; Hooper, C.; Preston, J.; Green, M.; Helmer, L.; Hammerson, J. K.; Schulze, J. N.; Minardi, D.; Gundappa, M. K.; Macqueen, D.; Hamilton, J.; Houston, R. D.; Bean, T. P.
10.1101/2022.06.10.495672 — genetics — Posted on 2022-06-12
2457 Pinpointing the distinctive impacts of ten cover crop species on the resident and active fractions of the soil microbiome
Cazzaniga, S. G.; Braat, L.; van den Elsen, S. J. J.; Lombaers-van der Plas, C. H.; Visser, J. H. M.; Macia Vicente, J.; Postma, J.; Mommer, L.; Helder, J.
10.1101/2022.06.10.495641 — ecology — Posted on 2022-06-12
2462 Precision Discovery of Novel Inhibitors of Human Cancer Target HsMetAP1 from Vast Unexplored Metagenomic Diversity
Liu, O. W.; Akers, S.; Alvarez, G.; Brown, S.; Cai, W.; Charlop-Powers, Z.; Crispell, K.; Goh, E.-B.; Hwang, W. W.; Eyles, T. H.; Ganesh, S.; Haverty, P.; Kulp, J. L.; Kulp, J. L.; Kurtz, Z.; Lubbe, A.; Jamison, M.; Milshteyn, A.; Mokthari, P.; Naylor, S. G.; Oteng-Pabi, S.; Overacker, R.; Robertson, A. W.; van Aggelen, H.; Viswanathan, U.; Yang, X.; Yoder, S.; Colletti, S. L.; Scannell, D. R.
10.1101/2022.06.11.495772 — microbiology — Posted on 2022-06-12
2465 Fungi with history: Unveiling the mycobiota of historic documents of Costa Rica
Escudero-Leyva, E.; Vieto, S.; Avendano, R.; Rojas-Gätjens, D.; Agüero, P.; Pacheco, C.; Montero, M. L.; Chaverri, P.; Chavarria, M.
10.1101/2022.06.12.495835 — microbiology — Posted on 2022-06-12
2466 Combinatorial encoding of odors in the mosquito antennal lobe
Singh, P.; Goyal, S.; Gupta, S.; Garg, S.; Tiwari, A.; Rajput, V.; Bates, A. S.; Gupta, A. K.; Gupta, N.
10.1101/2022.06.10.495686 — neuroscience — Posted on 2022-06-12
2467 Microglia and meningeal macrophages depletion delay the onset of experimental autoimmune encephalomyelitis
Montilla, A.; Zabala, A.; Er-Lukowiak, M.; Rissiek, B.; Magnus, T.; Rodriguez-Iglesias, N.; Sierra, A.; Matute, C.; Domercq, M.
10.1101/2022.06.10.495612 — neuroscience — Posted on 2022-06-12
2471 Allosteric feedback inhibition of deoxy-D-xylulose-5-phosphate synthase involves monomerization of the active dimer.
Di, X.; Ortega-Alarcon, D.; Kakumanu, R.; Baidoo, E. E. K.; Velazquez-Campoy, A.; RODRIGUEZ-CONCEPCION, M.; Perez-Gil, J.
10.1101/2022.06.12.495819 — biochemistry — Posted on 2022-06-12
2472 Insights into deuterostome evolution from the biphasic transcriptional programmes of hemichordates
Perez-Posada, A.; Lin, C.-Y.; Lin, C.-Y.; Chen, Y.-C.; Gomez-Skarmeta, J. L.; Yu, J.-K.; Su, Y.-H.; Tena, J. J.
10.1101/2022.06.10.495707 — evolutionary biology — Posted on 2022-06-12
2473 The TRIPLE PHD FINGERS proteins are required for SWI/SNF complex-mediated +1 nucleosome positioning and 5' transcript length determination in Arabidopsis.
Diego-Martin, B.; Perez-Alemany, J.; Candela-Ferre, J.; Corbalan-Acedo, A.; Pereyra, J.; Alabadi, D.; Jami-Alahmadi, Y.; Wohlschlegel, J.; Gallego-Bartolomé, J.
10.1101/2022.06.12.495191 — molecular biology — Posted on 2022-06-12
2474 The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice
Ullah, I.; Beaudoin-Bussieres, G.; Symmes, K.; Cloutier, M.; Ducas, E.; Tauzin, A.; Laumaea, A.; Begin, P.; Mothes, W.; Bazin, R.; Finzi, A.; Uchil, P. D.
10.1101/2022.06.10.495677 — immunology — Posted on 2022-06-12
2475 GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa
Nagle, M. F.; Yuan, J.; Kaur, D.; Ma, C.; Peremyslova, E.; Jiang, Y.; Willig, C. J.; Goralogia, G. S.; Nino de Rivera, A.; McEldowney, M.; Goddard, A.; Magnuson, A.; Muchero, W.; Li, F.; Strauss, S. H.
10.1101/2022.06.08.495082 — plant biology — Posted on 2022-06-12
2476 A low-cost device for cryoanesthesia of neonate rodents
Jamieson, B. B.; Konstantinou, G.; Cano-Ferrer, X.; de Launoit, E.; Renier, N.; Imbert, A.; Kohl, J.
10.1101/2022.06.09.495437 — neuroscience — Posted on 2022-06-12
2478 Along-tract quantification of resting-state BOLD hemodynamic response functions in white matter
Schilling, K.; Li, M.; Rheault, F.; Ding, Z.; Anderson, A. W.; Kang, H.; Landman, B. A.; Gore, J. C.
10.1101/2022.06.09.495555 — neuroscience — Posted on 2022-06-12
2479 From pseudotime to true dynamics: reconstructing a real-time axis for T cells differentiation
Gavish, A.; Chain, B.; Salame, T. M.; Antebi, Y. E.; Katz, S.; Reich-Zeliger, S.; Friedman, N.
10.1101/2022.06.09.495431 — systems biology — Posted on 2022-06-12
2480 Scale-free and oscillatory spectral measures of sleep stages in humans
Schneider, B.; Szalardy, O.; Ujma, P. P.; Simor, P.; Gombos, F.; Kovacs, I.; Dresler, M.; Bodizs, R.
10.1101/2022.06.09.495470 — bioinformatics — Posted on 2022-06-12
2481 Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis
Rizwan, M.; Ling, C.; Guo, C.; Liu, T.; Jiang, J.-X.; Bear, C. E.; Ogawa, S.; Shoichet, M. S.
10.1101/2022.06.09.495476 — bioengineering — Posted on 2022-06-12
2483 Long wavelength light reduces the negative consequences of dim light at night in the Cntnap2 mouse model of autism.
Wang, H.-B.; Zhou, D.; Luk, S. H. C.; Cha, H. I.; Mac, A.; Chae, R.; Matynia, A.; Harrison, B.; Afshari, S.; Block, G. D.; Ghiani, C. A.; Colwell, C. S.
10.1101/2022.06.09.494760 — neuroscience — Posted on 2022-06-12
2488 Prediction of HLA genotypes from single-cell transcriptome data
Solomon, B. D.; Zheng, H.; Dillon, L. W.; Goldman, J. D.; Heath, J. R.; Khatri, P.
10.1101/2022.06.09.495569 — bioinformatics — Posted on 2022-06-12
2491 PHAT: interpretable prediction of peptide secondary structures using hypergraph multi-head attention network and transfer learning
Jiang, Y.; Wang, R.; Feng, J.; Jin, J.; Liang, S.; Li, Z.; Yu, Y.; Ma, A.; Su, R.; Zou, Q.; Ma, Q.; Wei, L.
10.1101/2022.06.09.495580 — bioinformatics — Posted on 2022-06-12
2495 Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms
Wallen, Z. D.; Demirkan, A.; Twa, G.; Cohen, G.; Dean, M. N.; Standaert, D. G.; Sampson, T.; Payami, H.
10.1101/2022.06.08.495316 — genomics — Posted on 2022-06-12
2496 Triangulation fails when neither linguistic, genetic, nor archaeological data support the Transeurasian narrative
Tian, Z.; Tao, Y.; Zhu, K.; Jacques, G.; Ryder, R. J.; Alonso de la Fuente, J. A.; Antonov, A.; Xia, Z.; Zhang, Y.; Ji, X.; Ren, X.; He, G.; Guo, J.; Wang, R.; Yang, X.; Zhao, J.; Xu, D.; Gray, R. D.; Zhang, M.; Wen, S.; Wang, C.-C.; Pellard, T.
10.1101/2022.06.09.495471 — genetics — Posted on 2022-06-12
2499 Invasive genetic rescue: Dispersal following repeated culling reinforces the genetic diversity of an invasive mammal
Synnott, R.; Shuttleworth, C.; Everest, D.; Stevenson-Holt, C.; O'Reilly, C.; McDevitt, A. D.; O'Meara, D. B.
10.1101/2022.06.09.495496 — ecology — Posted on 2022-06-12
2500 High overexploitation risk and management shortfall in highly traded requiem sharks
Sherman, C. S.; Digel, E. D.; Zubick, P.; Eged, J.; Haque, A. B.; Matsushiba, J. H.; Simpfendorfer, C. A.; Sant, G.; Dulvy, N. K.
10.1101/2022.06.09.495558 — ecology — Posted on 2022-06-12
2503 Dual IgA/IgG family autoantibodies from individuals at-risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum
Chriswell, M.; Lefferts, A. R.; Clay, M.; Hsu, A.; Seifert, J.; Feser, M. L.; Maerz, M.; Rims, C.; Bloom, M.; Bemis, E. A.; Demoruelle, M. K.; Deane, K. D.; James, E. A.; Buckner, J. H.; Robinson, W. H.; Holers, V. M.; Kuhn, K. A.
10.1101/2022.06.09.495381 — immunology — Posted on 2022-06-12
2505 Intraoperative Spinal Cord Stimulation Mitigates Pain after Spine Surgery in Mice
Yamamoto, S.; Duong, A.; Kim, A.; Hu, C.; Wiemers, B. M.; Wang, J.; Chung, J. M.; La, J.-H.
10.1101/2022.06.09.495484 — neuroscience — Posted on 2022-06-12
2509 Cognitive exertion affects the appraisal of one's own and other people's pain
Riontino, L.; Fournier, R.; Lapteva, A.; Silvestrini, N.; Schwartz, S.; Corradi-Dell'Acqua, C.
10.1101/2022.06.09.495450 — neuroscience — Posted on 2022-06-12
2513 Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities
Daniliidou, M.; Eroli, F.; Alanko, V.; Goikolea, J.; Latorre-Leal, M.; Rodriguez-Rodriguez, P.; Griffiths, W. J.; Wang, Y.; Pacciarini, M.; Brinkmalm, A.; Zetterberg, H.; Blennow, K.; Rosenberg, A.; Bogdanovic, N.; Winblad, B.; Kivipelto, M.; Ibghi, D.; Cedazo-Minguez, A.; Maioli, S.; Sandebring-Matton, A.
10.1101/2022.06.09.495140 — neuroscience — Posted on 2022-06-12
2514 Whole-brain dynamical modeling for classification of Parkinson's disease
Jung, K.; Florin, E.; Patil, K. R.; Caspers, J.; Rubbert, C.; Eickhoff, S. B.; Popovych, O. V.
10.1101/2022.06.08.495360 — neuroscience — Posted on 2022-06-12
2516 Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey
Jagasia, R.; Bon, C.; Rasmussen, S. V.; Badillo, S.; Tehler, D.; Buchy, D.; Berrera, M.; Prasad, M.; Terrigno, M.; Pandya, N. J.; Costa, V.; Wang, C.; Pedersen, L.; Miller, M. T.; Dumong Erichsen, K.; Joenson, L.; Hipp, J.; Bonni, A.; Mueller, L.; Braendli-Baiocco, A.; Kremer, T.; Koller, E.; Hoener, M.
10.1101/2022.06.09.495066 — neuroscience — Posted on 2022-06-12
2519 Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development
Williamson, D.; Schwalbe, E. C.; Hicks, D.; Aldinger, K. A.; Lindsey, J.; Crosier, S.; Richardson, S.; Goddard, J.; Hill, R.; Castle, J.; Grabovska, Y.; Hacking, J.; Pizer, B.; Wharton, S. B.; Jacques, T. S.; Joshi, A.; Bailey, S.; Clifford, S. C.
10.1101/2022.06.09.495353 — cancer biology — Posted on 2022-06-12
2520 An integrative web-based software tool for multi-dimensional pathology whole-slide image analytics
Shen, A.; Wang, F.; Paul, S.; Bhuvanapalli, D.; Alayof, J.; Farris, A. B.; Teodoro, G.; Brat, D. J.; Kong, J.
10.1101/2022.06.08.495366 — bioinformatics — Posted on 2022-06-12
2526 Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures
Thouta, S.; Waldbrook, M. G.; Lin, S.; Mahadevan, A.; Mezeyova, J.; Soriano, M.; Goodchild, S. J.; Parrish, R. R.
10.1101/2022.06.08.494063 — neuroscience — Posted on 2022-06-12
2527 Electrophysiological Markers of Memory Consolidation in the Human Brain when Memories are Reactivated during Sleep
Creery, J. D.; Brang, D. J.; Arndt, J. D.; Bassard, A. M.; Towle, V. L.; Tao, J. X.; Wu, S.; Rose, S.; Warnke, P. C.; Issa, N.; Paller, K. A.
10.1101/2022.06.08.495049 — neuroscience — Posted on 2022-06-12
2529 Enhancing associative learning in rats with a computationally designed training protocol
Zhang, X. O.; Zhang, Y.; Engelke, D. S.; Cho, C. E.; Smolen, P.; Byrne, J. H.; Do Monte, F. H.
10.1101/2022.06.08.495364 — neuroscience — Posted on 2022-06-12
2531 Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos
Li, J.; Zhang, J.; Hou, W.; Yang, X.; Liu, X.; Zhang, Y.; Gao, M.; Zong, M.; Dong, Z.; Liu, Z.; Shen, J.; Cong, W.; Ding, C.; Gao, S.; Huang, G.; Kong, Q.
10.1101/2022.06.10.495405 — developmental biology — Posted on 2022-06-12
2533 Regulation of Aortic Morphogenesis and VE-Cadherin Dynamics by VEGF
Jadon, J.; Yelin, R.; Arraf, A. A.; Asleh, M. A.; Zaher, M.; Schultheiss, T. M.
10.1101/2022.06.09.495466 — developmental biology — Posted on 2022-06-12
2534 New functional vessels form after spinal cord injury in zebrafish
Ribeiro, A.; Rebocho da Costa, M.; de Sena-Tomas, C.; Charas Rodrigues, E.; Quiteria, R.; Macarico, T.; Constantino Rosa Santos, S.; Saude, L.
10.1101/2022.06.09.495446 — developmental biology — Posted on 2022-06-12
2538 Formation and function of the meninges arachnoid barrier around the developing brain
Derk, J.; Como, C.; Jones, H. E.; Joyce, L. R.; Bonney, S.; O'Rourke, R.; Pawlikowski, B.; Doran, K.; Siegenthaler, J. A.
10.1101/2022.06.10.495709 — developmental biology — Posted on 2022-06-12
2540 An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis
Leite, D. J.; Schoenauer, A.; Blakeley, G.; Harper, A.; Garcia-Castro, H.; Baudouin-Gonzalez, L.; Wang, R.; Sarkis, N.; Nikola, A. G.; Koka, V. S. P.; Kenny, N. J.; Turetzek, N.; Pechmann, M.; Solana, J.; McGregor, A. P.
10.1101/2022.06.09.495456 — developmental biology — Posted on 2022-06-12
2541 Neural plate progenitors give rise to both anterior and posterior pituitary cells
Chen, Q.; Leshkowitz, D.; Li, H.; van Impel, A.; Schulte-Merker, S.; Amit, I.; Levkowitz, G.
10.1101/2022.06.12.495791 — developmental biology — Posted on 2022-06-12
2542 A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.
Subramanian, A.; Wang, L.; Moss, T.; Voorhies, M.; Sangwan, S.; Stevenson, E.; Pulido, E. H.; Kwok, S.; Krogan, N. J.; Swaney, D. L.; Floor, S. N.; Sil, A.; Walter, P.; Mukherjee, S.
10.1101/2022.06.10.495705 — cell biology — Posted on 2022-06-12
2543 Skeletal muscle lineage is dispensable for appendage regeneration in axolotl
Hu, Y.; Pan, X.; Shi, Y.; Qiu, Y.; Wang, L.; Murawala, P.; Liu, Y.; Xing, W.; Tanaka, E.; Fei, J.
10.1101/2022.06.10.495631 — cell biology — Posted on 2022-06-12
2544 Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis
Jing, H.; Ogunmowo, T.; Raychaudhuri, S.; Kusick, G. F.; Imoto, Y.; Li, S.; Itoh, K.; Chapman, E. R.; Ha, T.; Watanabe, S.; Liu, J.
10.1101/2022.06.12.495801 — cell biology — Posted on 2022-06-12
2549 Ovule siRNAs methylate protein-coding genes in trans
Burgess, D.; Chow, H. T.; Grover, J. W.; Freeling, M.; Mosher, R. A.
10.1101/2021.06.10.447945 — plant biology — Posted on 2022-06-12
2552 Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
Greenberg, I.; Sokol, E.; Klein Goldberg, A.; Simkin, D.; Benhamou, M.; Bar-Shira, S.; Raz, M.; Grossman, R.; Yeini, E.; Ofek, P.; Liang, B.; Satchi-Fainaro, R.; Reuveni, H.; Rubinek, T.; Wolf, I.
10.1101/2022.06.10.495658 — cancer biology — Posted on 2022-06-12
2553 Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
Gil Vasquez, E.; Nasreddin, N.; Valbuena, G. N.; Mulholland, E. J.; Belnoue-Davis, H. L.; Eggington, H.; Schenck, R. O.; Wouters, V. M.; Wirapati, P.; Gilroy, K.; Lannagan, T. R. M.; Flanagan, D. J.; Najumudeen, A. K.; Omwenga, S.; McCorry, A. M. B.; Easton, A.; Koelzer, V. H.; East, J. E.; Morton, D.; Trusolino, L.; Maughan, T.; Campbell, A. D.; Loughrey, M. B.; Dunne, P. D.; Tsantoulis, P.; Huels, D. J.; Tejpar, S.; Sansom, O.; Leedham, S. J.
10.1101/2022.06.11.495729 — cancer biology — Posted on 2022-06-12
2554 Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death
Avelar, R.; Armstrong, A.; Carvette, G.; Puleo, N.; Gupta, R.; Colina, J.; Joseph, P.; Sobeck, A.; O'Connor, C.; Gandhi, A.; Dziubinski, M.; Ma, D.; Waggoner, S.; Zanotti, K.; Nagel, C.; Resnick, K.; Singh, S.; Thomas, D.; Skala, S.; Zhang, J.; Narla, G.; DiFeo, A.
10.1101/2022.06.10.495657 — cancer biology — Posted on 2022-06-12
2555 Orphan genes are clustered with allorecognition loci and may be involved in incompatibility and speciation in Neurospora
Wang, Z.; Wang, Y.; Kasuga, T.; Lopez-Giraldez, F.; Zhang, Y.; Zhang, Z.; Diaz, R.; Dong, C.; Sil, A.; Trail, F.; Yarden, O.; Townsend, J. P.
10.1101/2022.06.10.495464 — evolutionary biology — Posted on 2022-06-12
2558 Tau and α-synuclein shape microtubule organization and microtubule-dependent transport in neuronal dendrites
Rierola, M.; Trushina, N. I.; Monteiro-Abreu, N.; Conze, C.; Holtmannspoetter, M.; Kurre, R.; Holzer, M.; Arendt, T.; Heinisch, J. J.; Brandt, R.; Bakota, L.
10.1101/2022.06.09.495530 — neuroscience — Posted on 2022-06-12
2561 A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.
Subramanian, A.; Wang, L.; Moss, T.; Voorhies, M.; Sangwan, S.; Stevenson, E.; Pulido, E. H.; Kwok, S.; Krogan, N. J.; Swaney, D. L.; Floor, S. N.; Sil, A.; Walter, P.; Mukherjee, S.
10.1101/2022.06.10.495705 — cell biology — Posted on 2022-06-11
2562 GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology
Earley, Z. M.; Lisicka, W.; Sifakis, J. J.; Gamboa, R. A.; Kowalczyk, A.; Barlow, J.; Shaw, D. G.; Discepolo, V.; Tan, I. L.; Gona, S.; Ernest, J.; Matzinger, P.; Barreiro, L. B.; Morgun, A.; Bendelac, A.; Ismagilov, R. F.; Shulzhenko, N.; Riesenfeld, S. J.; Jabri, B.
10.1101/2021.10.28.466194 — immunology — Posted on 2022-06-11
2563 Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop
Cummins, B.; Vrana, J.; Moseley, R. C.; Eramian, H.; Deckard, A.; Fontanarrosa, P.; Bryce, D.; Weston, M.; Zheng, G.; Nowak, J.; Motta, F. C.; Eslami, M.; Johnson, K. L.; Goldman, R. P.; Myers, C. J.; Johnson, T.; Vaughn, M. W.; Gaffney, N.; Urrutia, J.; Gopaulakrishnan, S.; Biggers, V.; Higa, T.; Mosqueda, L.; Gameiro, M.; Gedeon, T.; Mischaikow, K.; Beal, J.; Bartley, B.; Mitchell, T.; Nguyen, T. T.; Roehner, N.; Haase, S. B.
10.1101/2022.06.10.495560 — synthetic biology — Posted on 2022-06-11
2564 Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer
Bell, E. S.; Shah, P.; Zuela - Sopilniak, N.; Kim, D.; Varlet, A.-A.; Morival, J. L. P.; McGregor, A. L.; Isermann, P.; Davidson, P.; Elacqua, J. J.; Lakins, J.; Vahdat, L.; Weaver, V.; Smolka, M. B.; Span, P.; Lammerding, J.
10.1101/2021.07.12.451842 — cancer biology — Posted on 2022-06-11
2565 Structural bases for blockade and activation of BK channels by Ba2+ ions
Srivastava, S.; Miranda Fernandez, P.; de Val, N.; Giraldez, T.; Zhu, J.; Cachau, R. E.; Holmgren, M.
10.1101/2022.06.10.495656 — biophysics — Posted on 2022-06-11
2567 MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis
Malmierca-Merlo, P.; Sanchez-Garcia, R.; Grillo-Risco, R.; Perez-Diez, I.; Catala-Senent, J. F.; de la Iglesia-Vaya, M.; Hidalgo, M. R.; Garcia-Garcia, F.
10.1101/2021.07.13.451905 — bioinformatics — Posted on 2022-06-11
2570 Separation of transcriptional repressor and activator functions in HDAC3
Tang, M.; Regadas, I.; Belikov, S.; Shilkova, O.; Xu, L.; Wernersson, E.; Liu, X.; Wu, H.; Bienko, M.; Mannervik, M.
10.1101/2022.06.11.495646 — molecular biology — Posted on 2022-06-11
2572 Low diversity and microdiversity of comammox bacteria in wastewater systems suggests wastewater-specific adaptation within the Ca. Nitrospira nitrosa cluster.
Cotto, I.; Vilardi, K. J.; Huo, L.; Fogarty, E. C.; Khunjar, W.; Wilson, C.; De Clippeleir, H.; Gilmore, K.; Bailey, E.; Lücker, S. J.; Pinto, A. J.
10.1101/2022.06.11.495745 — microbiology — Posted on 2022-06-11
2573 Detecting sources of immune activation and viral rebound in HIV infection
Wietgrefe, S.; Duan, L.; Anderson, J.; Marques, G.; Sanders, M.; Cummins, N. W.; Badley, A. D.; Dobrowolski, C.; Karn, J.; Pagliuzza, A.; Chomont, N.; Sannier, G.; Dube, M.; Kaufmann, D. E.; Zuck, P.; Wu, G.; Howell, B.; Reilly, C.; Herschhorn, A.; Schacker, T.; Haase, A. T.
10.1101/2022.06.08.495415 — immunology — Posted on 2022-06-11
2575 Galantamine Attenuates Autoinflammation in a Mouse Model of Familial Mediterranean Fever
Mughrabi, I. T.; Ochani, M.; Tanovic, M.; Wang, P.; Diamond, B.; Sherry, B.; Pavlov, V.; Ozen, S.; Kastner, D. L.; Chae, J. J.; Al-Abed, Y.
10.1101/2022.06.10.495119 — immunology — Posted on 2022-06-11
2576 Nanobody-mediated Complement Activation to Kill HIV-infected Cells
Pedersen, M. L.; Pedersen, D. V.; Winkler, M. B. L.; Olesen, H. G.; Sogaard, O. S.; Ostergaard, L.; Laursen, N. S.; Andersen, A. H. F.; Tolstrup, M.
10.1101/2022.06.09.495439 — immunology — Posted on 2022-06-11
2577 Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in a Mouse Model of the Human Pathogenic Mutation DRD2I212F
Rodriguez-Contreras, D.; Gong, S.; Lebowitz, J. J.; Fedorov, L. M.; Asad, N.; Dore, T. M.; Ford, C. P.; Williams, J. T.; Neve, K. A.
10.1101/2022.06.09.495548 — neuroscience — Posted on 2022-06-11
2579 AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death
Moral-Sanz, J.; Lewis, S. A.; MacMillan, S.; Meloni, M.; McClafferty, H.; Viollet, B.; Foretz, M.; del-Pozo, J.; Evans, A. M.
10.1101/2022.06.08.495329 — pathology — Posted on 2022-06-11
2581 A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
Vujovic, A.; de Rooij, L. P. M. H.; Keyvani Chahi, A.; Chen, H. T.; Yee, B.; Loganathan, S. K.; Liu, L.; Chan, D. C. H.; Tajik, A.; Tsao, E.; Moreira, S.; Joshi, P.; Xu, J.; Wong, N.; Zandi, S.; Aigner, S.; Dick, J. E.; Minden, M. D.; Schramek, D.; Yeo, G. W.; Hope, K. J.
10.1101/2022.06.11.494613 — cancer biology — Posted on 2022-06-11
2582 Nitric oxide S-nitrosylates CSF1R to augment the action 1 of CSF1R inhibition against castration resistant prostate cancer
Kuchakulla, M.; FIRDAUS, F.; QURESHI, R.; SONI, Y.; Van Booven, D.; SHAH, K.; Dulce, R. A.; Masterson, T.; Rosete, O. J.; Hare, J. M.; RAMASAMY, R.; ARORA, H.
10.1101/2022.06.09.495543 — cancer biology — Posted on 2022-06-11
2583 Pulsed transistor operation enables miniaturization of electrochemical aptamer based sensors
Bidinger, S. L.; Keene, S. T.; Han, S.; Plaxco, K. W.; Malliaras, G. G.; Hasan, T.
10.1101/2022.06.09.495532 — bioengineering — Posted on 2022-06-11
2584 Ion exchange biomaterials to capture daptomycin and prevent resistance evolution in off-target bacterial populations
Yeh, S.-L.; Narasimhalu, N.; vom Steeg, L. G.; Muthami, J.; LeConey, S.; He, Z.; Pitcher, M.; Cassady, H.; Morley, V. J.; Cho, S. H.; Bator, C.; Koshani, R.; Woods, R. J.; Hickner, M.; Read, A. F.; Sheikhi, A.
10.1101/2022.06.10.495716 — bioengineering — Posted on 2022-06-11
2586 Structural basis for tunable affinity and specificity of LxCxEdependentprotein interactions with the retinoblastoma protein family
Putta, S.; Alvarez, L.; Ludtke, S.; Sehr, P.; Muller, G.; Fernandez, S.; Tripathi, S.; Lewis, J.; Gibson, T.; Chemes, L.; Rubin, S.
10.1101/2022.06.10.495386 — biochemistry — Posted on 2022-06-11
2588 Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis
Meier, S.; Seddon, J. A.; Maasdorp, E.; Kleynhans, L.; du Plessis, N.; Loxton, A. G.; Malherbe, S. T.; Zak, D. E.; Thompson, E.; Duffy, F.; Kaufmann, S. H. E.; Ottenhoff, T. H. M.; Scriba, T. J.; Suliman, S.; Sutherland, J. S.; Winter, J.; Kuivaniemi, H.; Walzl, G.; Tromp, G.; GC6-74 Consortium, ; Catalysis TB Biomarkers Consortium,
10.1101/2022.06.10.495597 — genomics — Posted on 2022-06-11
2589 Graph-based pangenomics maximizes genotyping density and reveals structural impacts on fungal resistance
Vaughn, J. N.; Branham, S. E.; Abernathy, B. L.; Hulse-Kemp, A. M.; Rivers, A. R.; Levi, A.; Wechter, W. P.
10.1101/2022.06.10.495676 — genetics — Posted on 2022-06-11
2591 A lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance
Warring, S. L.; Malone, L. M.; Jayaraman, J.; Easingwood, R. A.; Rigano, L. A.; Frampton, R. A.; Visnovsky, S. B.; Addison, S. M.; Hernandez, L.; Pitman, A. R.; Lopez Acedo, E.; Kleffmann, T.; Templeton, M. D.; Bostina, M.; Fineran, P. C.
10.1101/2022.06.10.495718 — microbiology — Posted on 2022-06-11
2596 Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy
Margara, F.; Psaras, Y.; Wang, Z. J.; Schmid, M.; Doste, R.; Garfinkel, A.; Repetti, G. G.; Seidman, J.; Seidman, C.; Rodriguez, B.; Toepfer, C. N.; Bueno-Orovio, A.
10.1101/2022.06.08.495324 — bioengineering — Posted on 2022-06-11
2597 Macroscale Adipose Tissue from Cellular Aggregates: A Simplified Method of Mass Producing Cell-Cultured Fat for Food Applications
Yuen, J. S.; Saad, M. K.; Xiang, N.; Barrick, B. M.; DiCindio, H.; Li, C.; Zhang, S. W.; Rittenberg, M.; Lew, E. T.; Leung, G.; Pietropinto, J. A.; Kaplan, D. L.
10.1101/2022.06.08.495192 — bioengineering — Posted on 2022-06-11
2599 Evolutionary trajectory of the physicochemical mechanism of interaction of SARS-CoV-2 spike protein with ACE2
Planchais, C.; Reyes-Ruiz, A.; Lacombe, R.; Zarantonello, A.; Lecerf, M.; Revel, M.; Roumenina, L. T.; Atanasov, B. P.; Mouquet, H.; Dimitrov, J. D.
10.1101/2022.06.11.495733 — biochemistry — Posted on 2022-06-11
2600 Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences
Miura, F.; Miura, M.; Shibata, Y.; Furuta, Y.; Miyamura, K.; Ino, Y.; Bayoumi, A. M. A.; Oba, U.; Ito, T.
10.1101/2022.06.10.495194 — biochemistry — Posted on 2022-06-11
2601 Multiple lineages of Monkeypox virus detected in the United States, 2021-2022
Gigante, C. M.; Korber, B.; Seabolt, M. H.; Wilkins, K.; Davidson, W.; Rao, A. K.; Zhao, H.; Hughes, C. M.; Minhaj, F.; Waltenburg, M. A.; Theiler, J.; Smole, S.; Gallagher, G. R.; Blythe, D.; Myers, R.; Schulte, J.; Stringer, J.; Lee, P.; Mendoza, R. M.; Griffin-Thomas, L. A.; Crain, J.; Murray, J.; Atkinson, A.; Gonzalez, A. H.; Nash, J.; Batra, D.; Damon, I.; McQuiston, J.; Hutson, C. L.; McCollum, A. M.; Li, Y.
10.1101/2022.06.10.495526 — genomics — Posted on 2022-06-11
2605 Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase
Amstrup, S. K.; Sofos, N.; Karlsen, J. L.; Skjerning, R. B.; Boesen, T.; Enghild, J. J.; Hove-Jensen, B.; Brodersen, D. E.
10.1101/2022.06.09.495270 — biochemistry — Posted on 2022-06-11
2608 Neural basis for anxiety and anxiety-related physiological responses during a driving situation: An fMRI study
Sasaoka, T.; Harada, T.; Sato, D.; Michida, N.; Yonezawa, H.; Takayama, M.; Nouzawa, T.; Yamawaki, S.
10.1101/2021.11.30.470539 — neuroscience — Posted on 2022-06-11
2609 The role of APOBEC3B in lung tumour evolution and targeted therapy resistance
Caswell, D. R.; Mayekar, M. K.; Gui, P.; Law, E. K.; Vokes, N. I.; Ruiz, C. M.; Dietzen, M.; Angelova, M.; Bailey, C.; Pich, O.; Bakker, B.; Wu, W.; Humpton, T. J.; Kerr, D. L.; Hill, W.; Lu, W.-T.; Haderk, F.; Blakely, C. M.; Bakir, M. A.; Nagano, A.; Gimeno-Valiente, F.; Weeden, C.; Rowan, A.; McCoach, C. E.; Almeida, B.; Green, M.; Gomez, C.; Gini, B.; Nanjo, S.; Barbosa, D.; Moore, C.; Przewrocka, J.; Gronroos, E.; Priestnall, S.; Suarez-Bonnet, A.; Zverev, C.; Lighterness, S.; Cormack, J.; Olivas, V.; Cech, L.; Rule, B.; Ashford, P.; Durfee, C.; Temiz, N. A.; Tan, L.; Larson, L. K.; Argyr
10.1101/2020.12.18.423280 — cancer biology — Posted on 2022-06-11
2616 Early adversity changes the economic conditions of structural brain network organisation
Carozza, S.; Holmes, J.; Vertes, P. E.; Bullmore, E.; Arefin, T.; Pugliese, A.; Zhang, J.; Kaffman, A.; Akarca, D.; Astle, D.
10.1101/2022.06.08.495303 — neuroscience — Posted on 2022-06-11
2618 Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I
Kremling, V.; Loll, B.; Pach, S.; Dahmani, I.; Weise, C.; Wolber, G.; Chiantia, S.; Wahl, M. C.; Osterrieder, N.; Azab, W.
10.1101/2022.06.10.495596 — molecular biology — Posted on 2022-06-11
2621 A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging
Wang, Y. X.; Holbrook, C. A.; Hamilton, J. N.; Garoussian, J.; Afshar, M.; Su, S.; Schurch, C. M.; Lee, M. Y.; Goltsev, Y.; Kundaje, A.; Nolan, G. P.; Blau, H. M.
10.1101/2022.06.10.494732 — cell biology — Posted on 2022-06-10
2623 A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.
Subramanian, A.; Wang, L.; Moss, T.; Voorhies, M.; Sangwan, S.; Stevenson, E.; Pulido, E. H.; Kwok, S.; Krogan, N. J.; Swaney, D. L.; Floor, S. N.; Sil, A.; Walter, P.; Mukherjee, S.
10.1101/2022.06.10.495705 — cell biology — Posted on 2022-06-11
2627 Structural bases for blockade and activation of BK channels by Ba2+ ions
Srivastava, S.; Miranda Fernandez, P.; de Val, N.; Giraldez, T.; Zhu, J.; Cachau, R. E.; Holmgren, M.
10.1101/2022.06.10.495656 — biophysics — Posted on 2022-06-10
2628 At-home blood collection and stabilization in high temperature climates using homeRNA
Brown, L. G.; Haack, A. J.; Kennedy, D. S.; Adams, K. N.; Stolarczuk, J. E.; Takezawa, M. G.; Berthier, E.; Thongpang, S.; Lim, F. Y.; Chaussabel, D.; Garand, M.; Theberge, A. B.
10.1101/2022.03.23.485526 — bioengineering — Posted on 2022-06-10
2629 Strand-resolved mutagenicity of DNA damage and repair
Anderson, C. J.; Talmane, L.; Luft, J.; Nicholson, M. D.; Connelly, J.; Pich, O.; Campbell, S. E.; Sundaram, V.; Connor, F.; Ginno, P. A.; Liver Cancer Evolution Consortium, ; Lopez-Bigas, N.; Flicek, P.; Semple, C. A.; Odom, D. T.; Aitken, S. J.; Taylor, M. S.
10.1101/2022.06.10.495644 — genomics — Posted on 2022-06-10
2630 PTPN14, a modifier of HHT, protects SMAD4 from ubiquitination and turnover to potentiate BMP9 signaling in endothelial cells.
MAMAI, O.; Beleford, D.; Taylor, M.; Basu, S.; Cen, X.; Trilok, S.; Zhang, J.; Balmain, A.; Akhurst, R.
10.1101/2021.09.29.462397 — cell biology — Posted on 2022-06-10
2631 Confined migration induces heterochromatin formation and alters chromatin accessibility
Hsia, C.-R.; McAllister, J.; Hasan, O.; Judd, J.; Lee, S.; Agrawal, R.; Chang, C.-Y.; Soloway, P.; Lammerding, J.
10.1101/2021.09.22.461293 — cell biology — Posted on 2022-06-10
2633 Modulation of multiple gene clusters expression by a single PAS-LuxR transcriptional regulator
Vicente, C. M.; Payero, T. D.; Rodriguez-Garcia, A.; Barreales, E. G.; de Pedro, A.; Santos-Beneit, F.; Aparicio, J. F.
10.1101/2022.06.10.495441 — microbiology — Posted on 2022-06-10
2635 Bistability of prefrontal states gates access to consciousness
Dwarakanath, A.; Kapoor, V.; Werner, J.; Safavi, S.; Fedorov, L.; Logothetis, N. K.; Panagiotaropoulos, T. I.
10.1101/2020.01.29.924928 — neuroscience — Posted on 2022-06-10
2636 Motor Learning Drives Dynamic Patterns of Intermittent Myelination onLearning-Activated Axons
Bacmeister, C. M.; Huang, R.; Osso, L. A.; Thornton, M. A.; Conant, L.; Chavez, A. R.; Poleg-Polsky, A. G.; Hughes, E. G.
10.1101/2021.10.13.464319 — neuroscience — Posted on 2022-06-10
2641 Backtracking of influenza polymerase upon consecutive incorporation of nucleoside analogue T1106 directly observed by high resolution cryo-electron microscopy
Kouba, T.; Dubankova, A.; Drncova, P.; Donati, E.; Vidossich, P.; Speranzini, V.; Pflug, A.; Huchting, J.; Meier, C.; De Vivo, M.; Cusack, S.
10.1101/2022.06.10.495428 — molecular biology — Posted on 2022-06-10
2642 Loss of the protein disrupted in schizophrenia 1 (DISC1) impairs cardiac resistance against ischemia.
Gurdeep Marwahra, G.; Pinho, M. J.; Slagsvold, K. H.; Wahba, A.; Rosbjorgen, R. E.; Enguita, F. J.; Yang, K.; Ishizuka, K.; Casas, C. A. A.; Pettersen, K.; Bjorkoy, G.; Sawa, A.; Hoydal, M. A.
10.1101/2022.06.09.494639 — molecular biology — Posted on 2022-06-10
2644 Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans
Gusa, A.; Yadav, V.; Roth, C.; Williams, J. D.; Shouse, E. M.; Magwene, P. M.; Heitman, J.; Jinks-Robertson, S.
10.1101/2022.06.10.495668 — microbiology — Posted on 2022-06-10
2645 Multiple ParA/MinD ATPases coordinate the positioning of disparate cargos in a bacterial cell
Pulianmackal, L. T.; Limcaoco, J. M. I.; Ravi, K.; Yang, S.; Zhang, J.; Tran, M. K.; O'Meara, M. J.; Vecchiarelli, A. G.
10.1101/2022.06.09.495121 — microbiology — Posted on 2022-06-10
2647 Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex
Vargas, R.; Luna, M. J.; Freschi, L.; Murphy, K. C.; Ioerger, T. R.; Sassetti, C. M.; Farhat, M. R.
10.1101/2022.06.10.495637 — microbiology — Posted on 2022-06-10
2648 Fusarium culmorum produces NX-2 toxin simultaneously with deoxynivalenol and 3-acetyl-deoxynivalenol or nivalenol
Schiwek, S.; Alhussein, M.; Rodemann, C.; Budragchaa, T.; Beule, L.; von Tiedemann, A.; Karlovsky, P.
10.1101/2022.06.10.495629 — microbiology — Posted on 2022-06-10
2650 Genetic exchange in Leishmania is facilitated by IgM natural antibodies
Serafim, T. D.; Iniguez, E.; F. Barletta, A. B.; Doehl, J. S. P.; Short, M.; Lack, J.; Cecilio, P.; Nair, V.; Disotuar, M.; Wilson, T.; Coutinho-Abreu, I. V.; Oliveira, F.; Meneses, C.; Barillas-Mury, C.; Andersen, J.; Ribeiro, J. M. C.; Beverley, S. M.; Kamhawi, S.; Valenzuela, J. G.
10.1101/2022.06.09.495557 — microbiology — Posted on 2022-06-10
2651 Reovirus efficiently reassorts genome segments during coinfection and superinfection
Thoner, T. W.; Meloy, M. M.; Long, J. M.; Diller, J. R.; Slaughter, J. C.; Ogden, K. M.
10.1101/2022.06.09.495584 — microbiology — Posted on 2022-06-10
2653 IRF8 regulates efficacy of therapeutic anti-CD20 monoclonal antibodies
Grzelak, L.; Roesch, F.; Vaysse, A.; Biton, A.; Porrot, F.; Commere, P.-H.; Planchais, C.; Mouquet, H.; Vignuzzi, M.; Bruel, T.; Schwartz, O.
10.1101/2022.06.09.495444 — immunology — Posted on 2022-06-10
2654 Regulation of pDC Fate Determination by Histone Deacetylase 3
Zhang, Y.; He, Z.; Lai, W.; Shen, X.; Wu, T.; Lv, J.; Wu, L.
10.1101/2022.06.08.494949 — immunology — Posted on 2022-06-10
2656 G-Trap Assay I: Small GTPases as sensitive immune response biomarkers for active bacteremia
Clark, R.; Bondu, V.; Simons, P. C.; Shevy, L.; Castillo, E. F.; Young, S.; Kanagy, N.; Wandinger-Ness, A.; Howdieshell, T.; Buranda, T.
10.1101/2022.06.09.495550 — immunology — Posted on 2022-06-10
2659 Identification and genetic characterization of MERS-related coronavirus isolated from Nathusius' pipistrelle (Pipistrellus nathusii) near Zvenigorod (Moscow region, Russia)
Speranskaya, A. S.; Artyushin, I. V.; Samoilov, A. E.; Korneenko, E. V.; Khabudaev, K. V.; Ilina, E. N.; Yusefovich, A. P.; Safonova, M. V.; Dolgova, A. S.; Dedkov, V. G.; Daszak, P.; Gladkikh, A. S.
10.1101/2022.06.09.495421 — genomics — Posted on 2022-06-10
2669 Optimized dCas9 Transcription Activators for Plants
Zinselmeier, M.; Casas-Mollano, J. A.; Sychla, A.; Heinsch, S.; Voytas, D.; Smanski, M.
10.1101/2022.06.10.495638 — plant biology — Posted on 2022-06-10
2671 lsaBGC provides a comprehensive framework for evolutionary analysis of biosynthetic gene clusters within focal taxa
Salamzade, R.; Cheong, J. Z. A.; Sandstrom, S.; Swaney, M. H.; Stubbendieck, R. M.; Starr, N. L.; Currie, C. R.; Singh, A. M.; Kalan, L.
10.1101/2022.04.20.488953 — bioinformatics — Posted on 2022-06-10
2673 OTTERS: A powerful TWAS framework leveraging summary-level reference data
Dai, Q.; Zhou, G.; Zhao, H.; Vosa, U.; Franke, L.; Battle, A.; Teumer, A.; Lehtimaki, T.; Raitakari, O.; Esko, T.; eQTLGen Consortium, ; Epstein, M. P.; Yang, J.
10.1101/2022.03.30.486451 — genetics — Posted on 2022-06-10
2680 Salicaceae as potential host plants of Xylella fastidiosa in European temperate regions
Casarin, N.; Hasbroucq, S.; Pesenti, L.; Geradin, A.; Emond, A.; Lopez-Mercadal, J.; Miranda, M. A.; Gregoire, J.-C.; Bragard, C.
10.1101/2022.06.10.495618 — plant biology — Posted on 2022-06-10
2681 A pan-genome approach to decipher variants in the highly complex tandem repeat of LPA
Chin, C.-S.; Behera, S.; Metcalf, G.; Gibbs, R. A.; Boerwinkle, E.; Sedlazeck, F. J.
10.1101/2022.06.08.495395 — bioinformatics — Posted on 2022-06-10
2683 High-throughput and high-sensitivity biomarker monitoring in body fluid by FAIMS-enhanced fast LC SureQuant™ IS targeted quantitation
Kalogeropoulos, K.; Savickas, S.; Haack, A. M.; Larsen, C. A.; Mikosinski, J.; Schoof, E. M.; Smola, H.; Bundgaard, L.; auf dem Keller, U.
10.1101/2022.03.22.485266 — biochemistry — Posted on 2022-06-10
2689 Early adversity changes the economic conditions of structural brain network organisation
Carozza, S.; Holmes, J.; Vertes, P. E.; Bullmore, E.; Arefin, T.; Pugliese, A.; Zhang, J.; Kaffman, A.; Akarca, D.; Astle, D.
10.1101/2022.06.08.495303 — neuroscience — Posted on 2022-06-10
2692 Socio-economic disadvantage is associated with alterations in brain wiring economy
Siugzdaite, R.; Akarca, D.; Johnson, A.; Carozza, S.; Anwyl-Irvine, A. L.; Uh, S.; Smith, T.; Bignardi, G.; Dalmaijer, E.; Astle, D. E.
10.1101/2022.06.08.495247 — neuroscience — Posted on 2022-06-10
2694 Human pericytes degrade alpha-synuclein aggregates in a strain-dependent manner
Dieriks, B. V.; Highet, B.; Alik, A.; Bellande, T.; Stevenson, T. J.; Low, V.; Park, T. I.-H.; Correia, J.; Schweder, P.; Faull, R. L. M.; Melki, R.; Curtis, M. A.; Dragunow, M.
10.1101/2022.06.08.495286 — neuroscience — Posted on 2022-06-10
2695 Conserved reduction of m6A marks during aging and neurodegeneration is linked to altered translation of synaptic transcripts
Castro-Hernandez, R.; Berulava, T.; Metelova, M.; Epple, R.; Pena Centeno, T.; Sakib, M. S.; Burkhart, S.; Ninov, N.; Bohnsack, K. E.; Bohnsack, M. T.; Dellale, I.; Fischer, A.
10.1101/2022.06.08.495100 — neuroscience — Posted on 2022-06-10
2696 Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.
Patel, S.; Haider, A.; Alvarez-Guaita, A.; Bidault, G.; El-Sayed Moustafa, J. S.; Guiu-Jurado, E.; Tadross, J. A.; Warner, J.; Harrison, J.; Virtue, S.; Scurria, F.; Zvetkova, I.; Blüher, M.; Small, K. S.; O'Rahilly, S.; Savage, D. B.
10.1101/2022.06.08.495255 — physiology — Posted on 2022-06-10
2700 Genomic instability in patients with sex determination defects and germ cell cancer
Krivega, M.; Zimmer, J.; Slezko, A.; Frank-Herrmann, P.; Rehnitz, J.; Hohenfellner, M.; Betterndorf, M.; Luzarowski, M.; Strowitzki, T.
10.1101/2022.06.08.495249 — genetics — Posted on 2022-06-10
2703 Neurometabolic timecourse of healthy aging
Gong, T.; Hui, S. C. N.; Zollner, H. J.; Britton, M.; Song, Y.; Chen, Y.; Gudmundson, A. T.; Hupfeld, K. E.; Murali-Manohar, S.; Porges, E.; Oeltzschner, G.; Chen, W.; Wang, G.; Edden, R. A. E.
10.1101/2022.06.08.495050 — neuroscience — Posted on 2022-06-10
2705 Integrating inflammatory biomarker analysis and artificial intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis
Yu, S.; Kalinin, A. A.; Paraskevopoulou, M. D.; Maruggi, M.; Cheng, J.; Tang, J.; Icke, I.; Luo, Y.; Wei, Q.; Scheibe, D.; Hunter, J.; Singh, S.; Nguyen, D.; Carpenter, A. E.; Horman, S. R.
10.1101/2022.06.08.495258 — pharmacology and toxicology — Posted on 2022-06-10
2706 Nanotopography modulates intracellular excitable systems through cytoskeleton actuation
Yang, Q.; Miao, Y.; Banerjee, P.; Hourwitz, M. J.; Hu, M.; Qing, Q.; Iglesias, P. A.; Devreotes, P. N.; Fourkas, J. T.; Losert, W.
10.1101/2022.06.09.495528 — biophysics — Posted on 2022-06-10
2707 Human sperm TMEM95 binds eggs and facilitates membrane fusion
Tang, S.; Lu, Y.; Skinner, W. M.; Sanyal, M.; Lishko, P. V.; Ikawa, M.; Kim, P. S.
10.1101/2022.06.10.495573 — developmental biology — Posted on 2022-06-10
2708 Long-term Transverse Imaging of the Hippocampus with Glass Microperiscopes
Redman, W. T.; Wolcott, N. S.; Montelisciani, L.; Luna, G.; Marks, T. D.; Sit, K. K.; Yu, C.-H.; Smith, S. L.; Goard, M. J.
10.1101/2021.08.10.455885 — neuroscience — Posted on 2022-06-10
2709 A Parsimonious Description of Global Functional Brain Organization in Three Spatiotemporal Patterns
Bolt, T. S.; Nomi, J.; Bzdok, D.; Salas, J. A.; Chang, C.; Yeo, B. T. T.; Uddin, L. Q.; Keilholz, S.
10.1101/2021.06.20.448984 — neuroscience — Posted on 2022-06-10
2711 Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs
Liu, X.; Moscvin, M.; Oh, S.; Chen, T.; Choi, W.; Evans, B.; Rowell, S. M.; Nadeem, O.; Mo, C. C.; Sperling, A. S.; Anderson, K. C.; Yaqoob, Z.; Bianchi, G.; Sung, Y.
10.1101/2022.03.18.484926 — systems biology — Posted on 2022-06-10
2712 STK25 inhibits PKA signaling by phosphorylating PRKAR1A
Zhang, X.; Wang, B. Z.; Kim, M.; Nash, T.; Liu, B.; Rao, J.; Lock, R.; Tamargo, M.; Soni, R.; Belov, J.; Li, E.; Vunjak-Novakovic, G.; Fine, B.
10.1101/2022.01.27.478084 — physiology — Posted on 2022-06-10
2713 Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.
Wild, S. A.; Cannell, I. G.; Kania, K.; Nicholls, A.; Bressan, D.; CRUK IMAXT Grand Challenge Team, ; Hannon, G. J.; Sawicka, K.
10.1101/2021.12.09.471927 — cancer biology — Posted on 2022-06-10
2717 Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers
Kurzawa, N.; Stahl, M.; Leo, I.; Kunold, E.; Becher, I.; Audrey, A.; Mermelekas, G.; Huber, W.; Mateus, A.; Savitski, M.; Jafari, R.
10.1101/2022.06.10.495491 — biochemistry — Posted on 2022-06-10
2718 Inter-Individual Variability in Dorsal Stream Dynamics During Word Production
Liegeois-Chauvel, C.; Dubarry, A.-S.; Wang, I. Z.; Chauvel, P.; Gonzalez-Martinez, J.; Alario, F.- X.
10.1101/2022.04.01.486723 — neuroscience — Posted on 2022-06-10
2721 Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Al-Hilaly, Y. K.; Hurt, C.; Rickard, J. E.; Harrington, C. R.; Storey, J. M. D.; Wischik, C. M.; Serpell, L. C.; Siemer, A. B.
10.1101/2022.06.09.495520 — biophysics — Posted on 2022-06-10
2722 Hydrodynamic dissection of single cells in a microfluidic system
Paul, R.; Zhang, K. S.; Kurosu Jalil, M.; Castano, N.; Kim, S.; Tang, S. K. Y.
10.1101/2022.06.09.495579 — biophysics — Posted on 2022-06-10
2724 Inherent evolutionary unpredictability in cancer model system
Chattopadhyay, S.; Karlsson, J.; Manas, A.; Kanzaki, R.; Fredlund, E.; Murphy, A. J.; Morton, C. L.; Woolard, M. A.; Andersson, N.; Hansson, K.; Radke, K.; Davidoff, A. M.; Mohlin, S.; Pietras, K.; Bexell, D.; Gisselsson, D.
10.1101/2022.06.01.494285 — evolutionary biology — Posted on 2022-06-10
2726 Cis-membrane association of human ATG8 proteins N-terminus mediates autophagy
Tooze, S.; Zhang, W.; Nishimura, T.; Gahlot, D.; Saito, C.; Davis, C.; Jefferies, H. B. J.; Schreiber, A.; Thukral, L.
10.1101/2022.06.10.495627 — cell biology — Posted on 2022-06-10
2728 Distinct patterns of cortical manifold expansion and contraction underlie human sensorimotor adaptation
Gale, D. J.; Areshenkoff, C. N.; Standage, D. P.; Nashed, J. Y.; Markello, R. D.; Flanagan, J. R.; Smallwood, J.; Gallivan, J. P.
10.1101/2022.06.09.495516 — neuroscience — Posted on 2022-06-10
2731 Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family
Chen, Z.; Zakrzewska, S.; Hajare, H. S.; Alvarez-Buylla, A.; Abderemane-Ali, F.; Bogan, M.; Ramirez, D.; O'Connell, L. A.; Du Bois, J.; Minor, D. L.
10.1101/2022.06.09.495489 — biophysics — Posted on 2022-06-10
2733 Keap1-resistant ΔN-Nrf2 isoform does not translocate to the nucleus upon electrophilic stress
Mikac, S.; Dziadosz, A.; Padariya, M.; Kalathiya, U.; Fahraeus, R.; Marek-Trzonkowska, N.; Chrusciel, E.; Urban-Wojciuk, Z.; Papak, I.; Arcimowicz, Łukasz; Marjanski, T.; Rzyman, W.; Sznarkowska, A.
10.1101/2022.06.10.495609 — cell biology — Posted on 2022-06-10
2734 Peroxiredoxin 5 regulates osteogenic differentiation via interaction with hnRNPK during bone regeneration
Cho, E.; Che, X.; Ang, M. J.; Cheon, S.; Lee, J.; Kim, K.; Lee, C. H.; Lee, S.-Y.; Yang, H.-Y.; Moon, C.; Park, C.; Choi, J.-Y.; Lee, T.-H.
10.1101/2022.06.09.495435 — cell biology — Posted on 2022-06-10
2735 Chiral growth of adherent filopodia
Li, W.; Chung, W.-L.; Kozlov, M. M.; Medalia, O.; Geiger, B.; Bershadsky, A.
10.1101/2022.06.09.495577 — cell biology — Posted on 2022-06-10
2736 Anti-COVID-19 Activity of FDA Approved Drugs through RNA G-quadruplex Binding
Roy, S. S.; Sharma, S.; Rizvi, Z. A.; Sinha, D.; Gupta, D.; Rophina, M.; Sehgal, P.; Sadhu, S.; Tripathy, M. R.; Samal, S.; Maiti, S.; Scaria, V.; Sivasubbu, S.; Awasthi, A.; Harshan, K.; Jain, S.; Chowdhury, S.
10.1101/2022.05.31.493843 — molecular biology — Posted on 2022-06-10
2737 Transcriptome network analysis of human CD1c+ dendritic cells identifies an inflammatory cytokine-secreting subpopulation within the CD14+ DC3s that accumulates locally in type I IFN-negative autoimmunity to the eye
Hiddingh, S.; Pandit, A.; Verhagen, F.; Rijken, R.; Servaas, N.; Komer-Wichers, R.; Dam-van Loon, N. t.; Imhof, S. S.; Radstake, T.; de Boer, J. H.; Kuiper, J. J. W.
10.1101/2021.11.16.468816 — immunology — Posted on 2022-06-10
2738 Preclinical efficacy, safety, and immunogenicity of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2
Barreiro, A.; Prenafeta, A.; Bech-Sabat, G.; Roca, M.; Perozo, E.; March, R.; Gonzalez, L.; Madrenas, L.; Corominas, J.; Fernandez, A.; Moros, A.; Molas, M.; Pentinat, T.; Panosa, C.; Moreno, A.; Puigvert, E.; Pol, E.; Palmada, J.; Garriga, C.; Prat, T.; Vergara-Alert, J.; Lorca-Oro, C.; Roca, N.; Fernandez-Bastit, L.; Rodon, J.; Perez, M.; Segales, J.; Pradenas, E.; Marfil, S.; Trinite, B.; Ortiz, R.; Clotet, B.; Blanco, J.; Diaz Pedroza, J.; Ampudia Carrasco, R.; Rosales Salgado, Y.; Loubat Casanovas, J.; Capdevila Larripa, S.; Garcia Prado, J.; Barretina Ginesta, J.; Sistere-Oro, M.; Ceboll
10.1101/2021.11.22.469117 — immunology — Posted on 2022-06-10
2742 SARS-CoV-2 spike protein induces long-term TLR4-mediated synapse and cognitive loss recapitulating Post-COVID syndrome
Fontes-Dantas, F. L.; Fernandes, G. G.; Gutman, E. G.; De Lima, E. V.; Antonio, L. S.; Hammerle, M. B.; Mota-Araujo, H. P.; Colodeti, L. C.; Araujo, S. M. B.; da Silva, T. N.; Duarte, L. A.; Salvio, A. L.; Pires, K. L.; Leon, L. A. A.; Vasconcelos, C. C. F.; Romao, L.; Savio, L. E. B.; Silva, J. L.; da Costa, R.; Clarke, J. R.; Da Poian, A. T.; Alves-Leon, S. V.; Passos, G. F.; Figueiredo, C. P.
10.1101/2022.06.07.495149 — neuroscience — Posted on 2022-06-10
2743 Neural assemblies uncovered by generative modeling explain whole-brain activity statistics and reflect structural connectivity
van der Plas, T. L.; Tubiana, J.; Le Goc, G.; Migault, G.; Kunst, M.; Baier, H.; Bormuth, V.; Englitz, B.; Debregeas, G.
10.1101/2021.11.09.467900 — neuroscience — Posted on 2022-06-10
2744 The trifecta of disease avoidance, silique shattering resistance and flowering period elongation achieved by the BnaIDA editing in Brassica napus
Geng, R.; Shan, Y.; Li, L.; Shi, C.-L.; Wang, J.; Zhang, W.; Sarwar, R.; Xue, Y.-X.; Li, Y.-L.; Zhu, K.-M.; Wang, Z.; Xu, L.-Z.; Aalen, R. B.; Tan, X.-L.
10.1101/2022.06.09.493885 — plant biology — Posted on 2022-06-10
2745 End-to-end multimodal 3D imaging and machine learning workflow for non-destructive diagnosis of vine trunk diseases
Fernandez, R.; Le Cunff, L.; Merigeaud, S.; Verdeil, J.-L.; Perry, J.; Larignon, P.; Spilmont, A.-S.; Chatelet, P.; Cardoso, M.; Goze-Bac, C.; Moisy, C.
10.1101/2022.06.09.495457 — plant biology — Posted on 2022-06-10
2746 Profound geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
Juricic, P.; Lu, Y.-X.; Leech, T.; Drews, L. F.; Paulitz, J.; Lu, J.; Nespital, T.; Azami, S.; Regan, J. C.; Funk, E.; Fröhlich, J.; Grönke, S.; Partridge, L.
10.1101/2022.04.20.488884 — physiology — Posted on 2022-06-10
2751 Input to cortical layer 1 of somatosensory cortex
Ledderose, J.; Zolnik, T. A.; Toumazou, M.; Trimbuch, T.; Rosenmund, C.; Eickholt, B. J.; Jaeger, D.; Larkum, M. E.; Sachdev, R.
10.1101/2021.11.26.469979 — neuroscience — Posted on 2022-06-10
2753 Lysine 27 of histone H3.3 is a fine modulator of developmental gene expression and stands as an epigenetic checkpoint for lignin biosynthesis in Arabidopsis
FAL, K.; TOMKOVA, D.; LE MASSON, M.; FAIGENBOIM, A.; PANO, E.; ISHKHELI, N.; MOYAL, N.-L.; VILLETTE, C.; CHABOUTE, M.-E.; BERR, A.; WILLIAMS, L. E.; CARLES, C. C.
10.1101/2022.06.08.495374 — plant biology — Posted on 2022-06-10
2756 Nature's design of the osteochondral unit: microstructural differences between terrestrial and aquatic mammals
Mancini, I. A. D.; Levato, R.; Castilho, M. D.; Chen, M.; van Rijen, M. H. P.; IJsseldijjk, L. L.; Kik, M.; van Weeren, P. R.; Malda, J.
10.1101/2022.06.09.495440 — evolutionary biology — Posted on 2022-06-10
2758 The trifecta of disease avoidance, silique shattering resistance and flowering period elongation achieved by the BnaIDA editing in Brassica napus
Geng, R.; Shan, Y.; Li, L.; Shi, C.-L.; Wang, J.; Zhang, W.; Sarwar, R.; Li, Y.-L.; Zhu, K.-m.; Wang, Z.; Xu, L.-Z.; Aalen, R. B.; Tan, X.-L.
10.1101/2022.06.09.493885 — plant biology — Posted on 2022-06-10
2764 Phenotypic trait variation in a long-term, multisite common garden of Scots pine in Scotland
Beaton, J. K.; Perry, A.; Cottrell, J. E.; Iason, G. R.; Stockan, J. A.; Cavers, S.
10.1101/2022.06.08.495111 — ecology — Posted on 2022-06-10
2768 Input to cortical layer 1 of somatosensory cortex
Ledderose, J.; Zolnik, T. A.; Toumazou, M.; Trimbuch, T.; Rosenmund, C.; Eickholt, B. J.; Jaeger, D.; Larkum, M. E.; Sachdev, R.
10.1101/2021.11.26.469979 — neuroscience — Posted on 2022-06-10
2770 Proteotype Co-evolution and Diversity in Mammals
Ba, Q.; Hei, Y.; Dighe, A.; Li, W.; Maziarz, J.; Pak, I.; Wang, S.; Wagner, G.; Liu, Y.
10.1101/2022.06.08.495293 — systems biology — Posted on 2022-06-10
2772 Variation in morpho-physiological and metabolic responses to low nitrogen stress across the sorghum association panel
Grzybowski, M. W.; Zwiener, M.; Jin, H.; Wijewardane, N. K.; Atefi, A.; Naldrett, M. J.; Alvarez, S.; Ge, Y.; Schnable, J. C.
10.1101/2022.06.08.495271 — plant biology — Posted on 2022-06-10
2773 Laccaria bicolor pectin methylesterases are involved in ectomycorrhiza development with Populus tremula x Populus tremuloides
Chowdhury, J.; Kemppainen, M.; Delhomme, N.; Shutava, I.; Zhou, J.; Takahashi, J.; Pardo, A. G.; Lundberg-Felten, J.
10.1101/2022.06.08.495362 — plant biology — Posted on 2022-06-10
2774 An end-to-end workflow based on multimodal 3D imaging and machine learning for non-destructive diagnosis of grapevine trunk diseases
Fernandez, R.; le cunff, l.; Merigeaud, S.; Verdeil, J.-L.; Perry, J.; Larignon, P.; Spilmont, A.-S.; Chatelet, P.; Cardoso, M.; Goze-Bac, C.; Moisy, C.
10.1101/2022.06.09.495457 — plant biology — Posted on 2022-06-10
2775 Calibration of crop phenology models: Going beyond recommendations
Wallach, D.; Palosuo, T.; Thorburn, P.; Mielenz, H.; Buis, S.; Hochman, Z.; Gourdain, E.; Garcia, C.; Andrianasolo, F.; Dumont, B.; Ferrise, R.; Gaiser, T.; Gayler, S.; Hiremath, S.; Horan, H.; Hoogenboom, G.; Jansson, P.-E.; Jing, Q.; Qian, B.; Justes, E.; Kersebaum, K.-C.; Launay, M.; Lewan, E.; Mequanint, F.; Moriondo, M.; Nendel, C.; Padovan, G.; Schuetze, N.; Seserman, D.-M.; Souissi, A.; Shelia, V.; Specka, X.; Srivastava, A. K.; Trombi, G.; Weber, T.; Weihermueller, L.; Woehling, T.; Seidel, S.
10.1101/2022.06.08.495355 — plant biology — Posted on 2022-06-10
2776 IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+
Chung, J.; Tilunaite, A.; Ladd, D.; Hunt, H.; Soeller, C.; Crampin, E. J.; Johnston, S.; Roderick, H.; Rajagopal, V.
10.1101/2020.08.13.249144 — biophysics — Posted on 2022-06-10
2778 Genomic analysis unveils the role of genome degradation events and gene flux in the emergence and persistence of S. Paratyphi A lineages
Jacob, J. J.; Pragasam, A. K.; Vasudevan, K.; V, A.; Priya T, M.; Priya T, T.; Ray, P.; Gupta, M.; Kapil, A.; Bai, S. P.; Nagaraj, S.; Saigal, K.; Chandola, T. R.; Thomas, M.; Bavdekar, A.; Ebenezer, S. E.; Shastri, J.; De, A.; Dutta, S.; Alexander, A. P.; Koshy, R. M.; Jinka, D. R.; Singh, A. W.; Srivastava, S. K.; Anandan, S.; Dougan, G.; John, J.; Kang, G.; Veeraraghavan, B.; Mutreja, A.
10.1101/2022.06.09.495420 — genomics — Posted on 2022-06-10
2785 Heritability and host genomic determinants of switchgrass root-associated microbiota in field sites spanning its natural range.
Edwards, J.; Saran, U. B.; Bonnette, J.; MacQueen, A.; Yin, J.; Nguyen, T. u.; Schmutz, J.; Grimwood, J.; Pennacchio, L. A.; Daum, C.; del Rio, T. G.; Fritschi, F. B.; Lowry, D. B.; Juenger, T. E.
10.1101/2022.06.09.495345 — plant biology — Posted on 2022-06-09
2786 Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments
Higgins, G.; Higgins, F.; Peres, J.; Lang, D. M.; Abdalrahman, T.; Zaman, M.; Prince, S.; Franz, T.
10.1101/2022.06.09.495509 — biophysics — Posted on 2022-06-09
2789 Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Kinz-Thompson, C. D.; Lopez Redondo, M.; Mulligan, C.; Sauer, D. B.; Marden, J. J.; Song, J.; Tajkhorshid, E.; Hunt, J. F.; Stokes, D. L.; Mindell, J. A.; Wang, D.-N.; Gonzalez, R. L.
10.1101/2022.05.01.490196 — biophysics — Posted on 2022-06-09
2790 Collagen Pre-strain Discontinuity at the Cartilage - Bone Interface
Badar, W.; Ali, H.; Brooker, O. N.; Newham, E.; Snow, T.; Terrill, N. J.; Tozzi, G.; Fratzl, P.; Knight, M. M.; Gupta, H. S.
10.1101/2021.10.01.462427 — bioengineering — Posted on 2022-06-09
2792 Oct1 recruits the histone lysine demethylase Utx to promote lineage specification
Perovanovic, J.; Wu, Y.; Abewe, H.; Shen, Z.; Hughes, E.; Gertz, J.; Chandrasekharan, M. B.; Tantin, D.
10.1101/2020.12.01.406488 — developmental biology — Posted on 2022-06-09
2795 Rapid Activation of Hematopoietic Stem Cells
Thapa, R.; Elfassy, E.; Olender, L.; Sharabi, O.; Gazit, R.
10.1101/2022.06.01.494258 — immunology — Posted on 2022-06-09
2803 NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma
Song, D.; An, K.; Zhai, W.-L.; Feng, L.-Y.; Xu, Y.-J.; Sun, R.; Wang, Y.-Q.; Yang, Y.; Kan, Q.-C.; Tian, X.
10.1101/2022.06.08.495406 — cancer biology — Posted on 2022-06-09
2807 Direct laser writing of 3D electrodes on flexible substrates
Brown, M. A.; Zappitelli, K. M.; Singh, L.; Yuan, R. C.; Bemrose, M. A.; Brogden, V.; Miller, D. J.; Cogan, S. F.; Gardner, T. J.
10.1101/2022.06.07.495165 — bioengineering — Posted on 2022-06-09
2808 RNase H-based analysis of synthetic mRNA 5-prime cap incorporation
Chan, S.-H.; Whipple, J. M.; Dai, N.; Kelley, T. M.; Withers, K.; Tzertzinis, G.; Correa, I. R.; Robb, G. B.
10.1101/2022.02.02.478748 — biochemistry — Posted on 2022-06-09
2809 Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland
Hou, H.; Chan, C.; Yuki, K. E.; Sokolowski, D.; Roy, A.; Qu, R.; Uuskula-Reimand, L.; Faykoo-Martinez, M.; Hudson, M.; Corre, C.; Goldenberg, A.; Zhang, Z.; Palmert, M. R.; Wilson, M. D.
10.1101/2022.01.05.475069 — genomics — Posted on 2022-06-09
2813 p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin
Maeso-Alonso, L.; Alonso-Olivares, H.; Martinez-Garcia, N.; Villoch-Fernandez, J.; Lopez-Ferreras, L.; Puente-Santamaria, L.; Colas-Algora, N.; Fernandez-Corona, A.; Lorenzo-Marcos, M. E.; Jimenez, B.; Holmgren, L.; Wilhelm, M.; Millan, J.; del Peso, L.; Claesson-Welsh, L.; Marques, M. M.; Marin, M. C.
10.1101/2022.03.03.482832 — cell biology — Posted on 2022-06-09
2818 A multi-omics dataset for the analysis Frontotemporal Dementia genetic subtypes
Menden, K.; Francescatto, M.; Niyma, T.; Blauwendraat, C.; Dhingra, A.; Castillo Lizardo, M.; Fernandes, N.; Kaurani, L.; Kronenberg-Versteeg, D.; Atasu, B.; Sadikoglou, E.; Borroni, B.; Rodriguez Nieto, S.; Simon Sanchez, J.; Fischer, A.; Craig, D. W.; Neumann, M.; Bonn, S.; Rizzu, P.; Heutink, P.
10.1101/2020.12.01.405894 — neuroscience — Posted on 2022-06-09
2820 Enhanced nociceptor sprouting in a rabbit model of cerebral palsy
Reedich, E. J.; Genry, L. T.; Singer, M. A.; Cavarsan, C. F.; Mena Avila, E.; Boudreau, D. M.; Brennan, M. C.; Garrett, A. M.; Dowaliby, L.; Detloff, M. R.; Quinlan, K. A.
10.1101/2021.09.28.462176 — neuroscience — Posted on 2022-06-09
2821 Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania
Cuypers, B.; Meysman, P.; Erb, I.; Bittremieux, W.; Valkenborg, D.; Baggerman, G.; Mertens, I.; Sundar, S.; Khanal, B.; Notredame, C.; Dujardin, J.-C.; Domagalska, M. A.; Laukens, K.
10.1101/2021.09.14.460245 — systems biology — Posted on 2022-06-09
2823 Chromosome-level genome assembly of Rorippa aquatica revealed its allotetraploid origin and mechanisms of heterophylly upon submergence
Sakamoto, T.; Ikematsu, S.; Nakayama, H.; Mandakova, T.; Gohari, G.; Sakamoto, T.; Li, G.; Hou, H.; Matsunaga, S.; Lysak, M. A.; Kimura, S.
10.1101/2022.06.06.494894 — plant biology — Posted on 2022-06-09
2825 SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis
Njouendou, A. J.; Tiofack, A. A. Z.; Kenfack, R. N.; Ananga, S. N.; Bell, E. H. M. D.; Simo, G.; Hoheisel, J. D.; Siveke, J. T.; Lueong, S. S.
10.1101/2022.06.09.495487 — cancer biology — Posted on 2022-06-09
2826 Synthetic lethality-based prediction of cancer treatment response from histopathology images
Hoang, D.-T.; Dinstag, G.; Hermida, L. C.; Ben-Zvi, D. S.; Elis, E.; Caley, K.; Sinha, S.; Sinha, N.; Dampier, C. H.; Beker, T.; Aldape, K.; Aharonov, R.; Stone, E. A.; Ruppin, E.
10.1101/2022.06.07.495219 — cancer biology — Posted on 2022-06-09
2827 Hallucinating protein assemblies
Wicky, B. I. M.; Milles, L. F.; Courbet, A.; Ragotte, R. J.; Dauparas, J.; Kinfu, E.; Tipps, S.; Kibler, R. D.; Baek, M.; DiMaio, F.; Li, X.; Carter, L.; Kang, A.; Nguyen, H.; Bera, A. K.; Baker, D.
10.1101/2022.06.09.493773 — biophysics — Posted on 2022-06-09
2832 Multiplex CRISPR strategy targeting viral genome for agriculture and clinical use
Yang, L.; Zheng, Z.; Xu, L.; Dou, H.; Zhou, Y.; Feng, X.; He, X.; Tian, Z.; Song, L.; Gao, Y.; Mo, G.; Hu, J.; Zhao, H.; Wei, H.; Church, G. M.
10.1101/2022.06.09.495443 — bioengineering — Posted on 2022-06-09
2833 Optical Modulation of Blood-Brain-Tumor Barrier Permeability Enhances Drug Delivery in Diverse Preclinical Glioblastoma Models
Cai, Q.; Li, X.; Xiong, H.; Fan, H.; Gao, X.; Vemireddy, V.; Margolis, R.; Li, J.; Ge, X.; Giannotta, M.; Dejana, E.; Hoyt, K.; Bachoo, R.; Qin, Z.
10.1101/2022.06.07.495027 — bioengineering — Posted on 2022-06-09
2834 Structure of a HIV-1 IN-Allosteric Inhibitor Complex at 2.93 Angstrom Resolution: Routes to Inhibitor Optimization
Eilers, G.; Gupta, K.; Allen, A.; Montermoso, S.; Murali, H.; Sharp, R.; Hwang, Y.; Bushman, F.; Van Duyne, G.
10.1101/2022.06.09.495524 — biochemistry — Posted on 2022-06-09
2837 Glutamine metabolism modulates chondrocyte inflammatory response
Arra, M.; Swarnkar, G.; Adapala, N. S.; Naqvi, S.-K. B.; Cai, L.; Farooq Rai, M.; Mbalaviele, G.; Brophy, R.; Abu-Amer, Y.
10.1101/2022.06.09.495504 — biochemistry — Posted on 2022-06-09
2838 Genomics of cold adaptations in the Antarctic notothenioid fish radiation.
Bista, I.; Wood, J. M. D.; Desvignes, T.; McCarthy, S. A.; Matschiner, M.; Ning, Z.; Tracey, A.; Torrance, J.; Sims, Y.; Chow, W.; Smith, M.; Oliver, K.; Haggerty, L.; Salzburger, W.; Postlethwait, J. H.; Howe, K.; Clark, M. S.; Detrich, W. H.; Cheng, C.- H. C.; Miska, E. A.; Durbin, R.
10.1101/2022.06.08.494096 — genomics — Posted on 2022-06-09
2841 Lake Erie fish safe to eat yet afflicted by algal hepatotoxins
Shahmohamadloo, R. S.; Bhavsar, S. P.; Ortiz Almirall, X.; Marklevitz, S. A. C.; Rudman, S. M.; Sibley, P. K.
10.1101/2022.06.07.495188 — ecology — Posted on 2022-06-09
2843 Gene structure heterogeneity drives transcription noise within human chromosomes
Chiang, M.; Brackley, C. A.; Naughton, C.; Nozawa, R.-S.; Battaglia, C.; Marenduzzo, D.; Gilbert, N.
10.1101/2022.06.09.495447 — molecular biology — Posted on 2022-06-09
2844 Genome-wide subcellular protein localisation in the flagellate parasite Trypanosoma brucei
Billington, K.; Halliday, C.; Madden, R.; Dyer, P.; Carrington, M.; Vaughan, S.; Hertz-Fowler, C.; Dean, S.; Sunter, J. D.; Wheeler, R. J.; Gull, K.
10.1101/2022.06.09.495287 — microbiology — Posted on 2022-06-09
2847 Strengthening of enterococcal biofilms by Esp
Spiegelman, L.; Bahn-Suh, A.; Montano, E.; Zhang, L.; Hura, G.; Patras, K.; Kumar, A.; Tezcan, A.; Nizet, V.; Tsutakawa, S.; Ghosh, P.
10.1101/2022.06.09.495547 — microbiology — Posted on 2022-06-09
2850 Measures of Implicit and Explicit Adaptation Do Not Linearly Add
't Hart, B. M.; Taqvi, U.; Gastrock, R. Q.; Ruttle, J. E.; Modchalingam, S.; Henriques, D. Y. P.
10.1101/2022.06.07.495044 — neuroscience — Posted on 2022-06-09
2853 Discovery of synapse-specific RNA N6-methyladenosine readers associated with the consolidation of fear extinction memory
Madugalle, S. U.; Liau, W.-S.; Zhao, Q.; Li, X.; Gong, H.; Marshall, P. R.; Periyakaruppiah, A.; Zajaczkowski, E. L.; Leighton, L. J.; Ren, H.; Musgrove, M.; Davies, J.; Rauch, S.; He, C.; Dickinson, B.; Fletcher, L.; Fulopova, B.; Williams, S. R.; Spitale, R. C.; Bredy, T. W.
10.1101/2022.06.07.495230 — neuroscience — Posted on 2022-06-09
2857 A cellular assay for spike/ACE2 fusion: quantification of fusion-inhibitory antibodies after COVID-19 and vaccination
Abdul, F.; Ribaux, P.; Caillon, A.; Malezieux, A.; Prendki, V.; Zhukovsky, N.; Delhaes, F.; Krause, K.-H.; Preynat-Seauve, O.
10.1101/2022.06.09.495433 — microbiology — Posted on 2022-06-09
2858 Tracking infectious entry routes of SARS-CoV-2
Kreutzberger, A. J. B.; Sanyal, A.; Saminathan, A.; Bloyet, L.-M.; Stumpf, S.; Liu, Z.; Ojha, R.; Patjas, M. T.; Geneid, A.; Scanavachi, G.; Doyle, C. A.; Somerville, E.; Cunha Correira, R.; Di Caprio, G.; Toppila-Salmi, S.; Makitie, A.; Kiessling, V.; Vapalahti, O.; Whelan, S. P. J.; Balistreri, G.; Kirchhausen, T.
10.1101/2022.06.09.495472 — microbiology — Posted on 2022-06-09
2862 Anopheles albimanus is a potential alphavirus vector in the Americas
Terradas, G.; Novelo, M.; Metz, H. C.; Brustolin, M.; Rasgon, J. L.
10.1101/2022.06.09.495519 — microbiology — Posted on 2022-06-09
2864 Rotavirus spike protein VP4 mediates viroplasm assembly by association to actin filaments
Vetter, J.; Papa, G.; Seyffert, M.; Gunasekera, K.; De Lorenzo, G.; Wiesendanger, M.; Reymond, J.-L.; Fraefel, C.; Burrone, O. R.; Eichwald, C.
10.1101/2022.06.08.495416 — microbiology — Posted on 2022-06-09
2865 SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.
Takamatsu, Y.; Omata, K.; Shimizu, Y.; Kinoshita-Iwamoto, N.; Terada, M.; Suzuki, T.; Morioka, S.; Uemura, Y.; Ohmagari, N.; Maeda, K.; Mitsuya, H.
10.1101/2022.06.09.495422 — microbiology — Posted on 2022-06-09
2866 ARF6 is an important host factor for SARS-CoV-2 infection in vitro
Mirabelli, C.; Sherman, E. J.; Wotring, J. W.; El Saghir, J.; Bragazzi Cunha, J.; Harder, J.; Sexton, J. Z.; Emmer, B. T.; Wobus, C. E.
10.1101/2022.06.09.495482 — microbiology — Posted on 2022-06-09
2867 State-dependent protein-protein interactions mediating 4-1BB CAR Signaling
Ritmeester-Loy, S. A.; Lautz, J. D.; Zhang-Wong, Y.; Gustafson, J. A.; Wilson, A. L.; Lin, C.; Gafken, P. R.; Jensen, M. C.; Orentas, R.; Smith, S. E.
10.1101/2022.06.07.495180 — immunology — Posted on 2022-06-09
2868 Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimers Disease
Liu, Y.; Fong, B. C.; Harris, R. A.; McNicoll, M.-M.; Abdi, A. A.; Cuthbert, J. B.; Cook, D. P.; Figeys, D.; Wang, J.; Vanderhyden, B. C.; Slack, R. S.
10.1101/2022.06.08.495344 — neuroscience — Posted on 2022-06-09
2871 Ribosome display of N-linked glycoproteins in cell-free extracts
Chung, S. S.; Bidstrup, E. J.; Hershewe, J. M.; Warfel, K. F.; Jewett, M. C.; DeLisa, M. P.
10.1101/2022.06.09.495442 — synthetic biology — Posted on 2022-06-09
2872 Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths
Gaiti, F.; Chamely, P.; Hawkins, A. G.; Cortes-Lopez, M.; Swett, A. D.; Ganesan, S.; Mouhieddine, T. H.; Dai, X.; Kluegel, L.; Chen, C.; Batta, K.; Beaulaurier, J.; Drong, A. W.; Hickey, S.; Dusaj, N.; Mullokandov, G.; Su, J.; Chaligne, R.; Juul, S.; Harrington, E.; Knowles, D. A.; Wiseman, D. H.; Ghobrial, I. M.; Taylor, J.; Abdel-Wahab, O.; Landau, D. A.
10.1101/2022.06.08.495292 — cancer biology — Posted on 2022-06-09
2873 Hyaluronic acid biosynthesis promotes an invasive, stem-like cancer cell phenotype by broadly altering metabolism
Shimpi, A. A.; Tan, M. L.; Vilkhovoy, M.; Dai, D.; Roberts, L. M.; Kuo, J. C.-H.; Huang, L.; Varner, J.; Paszek, M. J.; Fischbach, C.
10.1101/2022.06.08.495338 — cancer biology — Posted on 2022-06-09
2874 MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
Soto-Feliciano, Y. M.; Zhu, C.; Morris, J. P.; Huang, C.-h.; Koche, R. P.; Ho, Y.-j.; Banito, A.; Chen, C.-w.; Shroff, A.; Tian, S.; Geulah, L.; Chen, C.-c.; Fennell, M.; Armstrong, S.; Allis, C. D.; Tschaharganeh, D.; Lowe, S. W.
10.1101/2022.06.07.495174 — cancer biology — Posted on 2022-06-09
2876 A pan-genome approach to decipher variants in the highly complex tandem repeat of LPA
Chin, C.-S.; Behera, S.; Metcalf, G.; Gibbs, R. A.; Boerwinkle, E.; Sedlazeck, F. J.
10.1101/2022.06.08.495395 — bioinformatics — Posted on 2022-06-09
2877 Mechanical properties of breast, kidney, and thyroid tumours measured by AFM: relationship with tissue structure
Levillain, A.; Confavreux, C. B.; Decaussin-Petrucci, M.; Durieux, E.; Paparel, P.; Le-Bail Carval, K.; Maillard, L.; Bermond, F.; Mitton, D.; Follet, H.
10.1101/2022.06.09.495321 — bioengineering — Posted on 2022-06-09
2881 Highly accurate isoform identification for the human transcriptome
Sommer, M. J.; Cha, S.; Varabyou, A.; Rincon, N.; Park, S.; Minkin, I.; Pertea, M.; Steinegger, M.; Salzberg, S.
10.1101/2022.06.08.495354 — genomics — Posted on 2022-06-09
2882 Multiplexed transcriptome discovery of RNA binding protein binding sites by antibody-barcode eCLIP
Lorenz, D. A.; Shen, K. A.; Her, H.-L.; Rothamel, K.; Hutt, K. R.; Nojadera, A. C.; Bruns, S. C.; Manakov, S. A.; Chapman, K. B.; Yeo, G. W.
10.1101/2022.06.08.495357 — genomics — Posted on 2022-06-09
2884 Luminal progenitors undergo partial epithelial-to-mesenchymal transition at the onset of basal-like breast tumorigenesis
Landragin, C.; Saichi, M.; Prompsy, P.; Durand, A.; Mesple, J.; Trouchet, A.; Faraldo, M.; Salmon, H.; Vallot, C.
10.1101/2022.06.08.494710 — cancer biology — Posted on 2022-06-09
2885 Subtype-specific single β1 integrin mechanics for activation, mechanotransduction and cytoskeleton remodeling
Jo, M. H.; Li, J.; Jaumouille, V.; Hao, Y.; Coppola, J.; Yan, J.; Waterman, C. M.; Springer, T. A.; Ha, T.
10.1101/2022.06.08.495291 — biophysics — Posted on 2022-06-09
2886 Markov State Modelling Reveals Heterogeneous Drug-Inhibition Mechanism of Calmodulin
Westerlund, A. M.; Sridhar, A.; Dahl, L.; Andersson, A.; Bodnar, A.-Y.; Delemotte, L.
10.1101/2022.06.08.495419 — biophysics — Posted on 2022-06-09
2887 MicroFPGA: an affordable FPGA platform for microscope control
Deschamps, J.; Kieser, C.; Hoess, P.; Deguchi, T.; Ries, J.
10.1101/2022.06.07.495178 — biophysics — Posted on 2022-06-09
2888 Emergent Actin Flows Explain Diverse Parasite Gliding Modes
Hueschen, C. L.; Segev Zarko, L.-a.; Chen, J.-H.; LeGros, M. A.; Larabell, C. A.; Boothroyd, J. C.; Phillips, R.; Dunn, A. R.
10.1101/2022.06.08.495399 — biophysics — Posted on 2022-06-09
2889 Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel
Petroff, J. T.; Dietzen, N. M.; Santiago-McRae, E.; Deng, B.; Washington, M. S.; Chen, L. J.; Moreland, K. T.; Deng, Z.; Rau, M.; Fitzpatrick, J. A.; Yuan, P.; Joseph, T. T.; Henin, J.; Brannigan, G.; Cheng, W. W.
10.1101/2022.06.07.494883 — biophysics — Posted on 2022-06-09
2892 PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, A. U.; Karapetsas, A.; Nirujogi, R. S.; Chatterjee, D.; Phung, T. K.; Wightman, M.; Gourlay, R.; Morrice, N.; Mathea, S.; Knapp, S.; Alessi, D. R.
10.1101/2022.06.09.495448 — biochemistry — Posted on 2022-06-09
2895 EZH2/ hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
Lin, Z.-S.; Chung, C.-C.; Liu, Y.-C.; Chang, C.-H.; Liu, H.-C.; Liang, Y.-Y.; Huang, T.-L.; Chen, T.-M.; Lee, C.-H.; Tang, C.-H.; Chen, Y.-H.; Hung, M.-C.
10.1101/2022.06.07.495151 — cancer biology — Posted on 2022-06-09
2896 Gene signature for predicting homologous recombination deficiency in triple-negative breast cancer
Pan, J.-W.; Ng, P.-S.; Zabidi, M. M. A.; Nur Fatin, P.; Teo, J.-Y.; Hasan, S. N.; Yip, C.-H.; Rajadurai, P.; Looi, L.-M.; Taib, A. M.; Rueda, O. M.; Caldas, C.; Chin, S.-F.; Lim, J. M. C.; Teo, S.-H.
10.1101/2022.06.08.495296 — cancer biology — Posted on 2022-06-09
2897 Uncovering the universality of self-replication in protein aggregation and its link to disease.
Meisl, G.; Xu, C. K.; Taylor, J. D.; Michaels, T. C.; Levin, A.; Otzen, D. E.; Klenerman, D.; Matthews, S.; Linse, S.; Andreasen, M.; Knowles, T.
10.1101/2022.06.08.495339 — biophysics — Posted on 2022-06-09
2902 The efficacy of EphA2 tyrosine phosphorylation increases with EphA2 oligomer size
Zapata-Mercado, E.; Biener, G.; McKenzie, D.; Wimley, W. C.; Pasquale, E. B.; Raicu, V.; Hristova, K.
10.1101/2022.06.07.495003 — biophysics — Posted on 2022-06-09
2904 A novel cuproptosis-related long non-coding RNAs model that effectively predicts prognosis in hepatocellular carcinoma
Huang, E.; Ma, N.; Ma, T.; Zhou, J.; Yang, W.; Liu, C.; Hou, Z.; Chen, S.; Zong, Z.; Zeng, B.; Li, Y.; Zhou, T.
10.1101/2022.06.07.495148 — bioinformatics — Posted on 2022-06-09
2905 Large-scale identification of phospho-modulated motif-based protein-protein interactions
Kliche, J.; Garvanska, D. H.; Simonetti, L.; Badgujar, D.; Dobritzsch, D.; Nilsson, J.; Davey, N. E.; Ivarsson, Y.
10.1101/2022.06.08.495335 — biochemistry — Posted on 2022-06-09
2908 The Gossypium herbaceum L. Wagad genome as a resource for understanding cotton domestication
Ramaraj, T.; Grover, C. E.; Mendoza, A. C.; Arick, M. A.; Jareczek, J. J.; Leach, A. G.; Peterson, D. G.; Wendel, J. F.; Udall, J. A.
10.1101/2022.06.07.494775 — genomics — Posted on 2022-06-09
2910 Circulating plasma IL-13 and periostin are dysregulated type 2 inflammatory biomarkers in prurigo nodularis: a cluster analysis
Parthasarathy, V.; Cravero, K.; Deng, J.; Sun, Z.; Engle, S.; Auxier, A.; Hahn, N.; Sims, J. T.; Okragly, A.; Alphonse, M. P.; Kwatra, S. G.
10.1101/2022.06.07.495051 — immunology — Posted on 2022-06-09
2913 Socioeconomic Resources are Associated with Distributed Alterations of the Brain's Intrinsic Functional Architecture in Youth
Sripada, C.; Gard, A. M. S.; Angstadt, M.; Taxali, A.; Greathouse, T.; McCurry, K.; Hyde, L. W.; Weigard, A.; Walczyk, P.; Heitzeg, M.
10.1101/2022.06.07.495160 — neuroscience — Posted on 2022-06-09
2916 Site-specific C-terminal fluorescent labeling of Tau protein
Bryan, L.; Awasthi, S.; Li, Y.; Nirmalraj, P. N.; Balog, S.; Yang, J.; Mayer, M.
10.1101/2022.06.07.495075 — biophysics — Posted on 2022-06-09
2918 prolfqua: A Comprehensive R-package for Proteomics Differential Expression Analysis
Wolski, W. E.; Nanni, P.; Grossmann, J.; d'Errico, M.; Schlapbach, R.; Panse, C.
10.1101/2022.06.07.494524 — bioinformatics — Posted on 2022-06-09
2922 Quantifying the Human Cost of Global Warming
Lenton, T. M.; Xu, C.; Abrams, J. F.; Ghadiali, A.; Loriani, S.; Sakschewski, B.; Zimm, C.; Ebi, K. L.; Dunn, R. R.; Svenning, J.-C.; Scheffer, M.
10.1101/2022.06.07.495131 — ecology — Posted on 2022-06-09
2924 Monitoring regional astrocyte diversity by cell-type specific proteomic labeling in vivo
Prabhakar, P.; Pielot, R.; Landgraf, P.; Wissing, J.; Bayrhammer, A.; van Ham, M.; Gundelfinger, E. D.; Jänsch, L.; Dieterich, D. C.; Müller, A.
10.1101/2022.06.07.495069 — neuroscience — Posted on 2022-06-09
2929 Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Cardenas Canales, E. M.; Stockmaier, S.; Cronin, E.; Rocke, T.; Osorio, J. E.; Carter, G. G.
10.1101/2022.06.06.495012 — animal behavior and cognition — Posted on 2022-06-09
2931 Long-read RNA Sequencing Improves the Annotation of the Equine Transcriptome
Peng, S.; Dahlgren, A. R.; Hales, E. N.; Barber, A. M.; Kalbefleich, T.; Petersen, J. L.; Bellone, R. R.; Mackowski, M.; Cappelli, K.; Capomaccio, S.; Coleman, S. J.; Distl, O.; Giulotto, E.; Waud, B.; Hamilton, N. A.; Leeb, T.; Lindgren, G.; Lyons, L. A.; McCue, M.; MacLeod, J. N.; Metzger, J.; Mickelson, J. R.; Murphy, B. A.; Orlando, L.; Penedo, C.; Raudsepp, T.; Strand, E.; Tozaki, T.; Trachsel, D. S.; Velie, B. D.; Wade, C. M.; Cieslak, J.; Finno, C. J.
10.1101/2022.06.07.495038 — genomics — Posted on 2022-06-09
2933 Planktonic functional diversity changes in synchrony with lake ecosystem state
O'Brien, D. A.; Gal, G.; Thackeray, S. J.; Matsuzaki, S.-i. S.; Blanchard, J.; Clements, C. F.
10.1101/2022.06.07.495076 — ecology — Posted on 2022-06-09
2934 Regulation of protein translation by TRIM21
Li, H.; Liu, S.; Feng, Q.; Deng, R.; Wang, J.; Wang, X.; Tian, R.; Xu, Y.; Chen, S.; Liu, Q.; Wang, L.; Li, X.; Wang, M.; Peng, Y.; Tang, S.; Xue, B.; Zhu, H.
10.1101/2022.06.07.495079 — immunology — Posted on 2022-06-09
2935 Feedforward attentional selection in sensory cortex
Westerberg, J. A.; Schall, J. D.; Woodman, G. F.; Maier, A.
10.1101/2022.06.06.495037 — neuroscience — Posted on 2022-06-09
2937 Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Choi, M. L.; Chappard, A.; Singh, B. P.; Maclachlan, C.; Rodrigues, M.; Fedotova, E.; Berezhnov, A.; De, S.; Peddie, C.; Athauda, D.; Virdi, G. S.; Zhang, W.; Evans, J. R.; Wernick, A.; Zanjani, Z.; Angelova, P. R.; Esteras, N.; Andrey, A.; Morris, K.; Jeacock, K.; Tosatto, L.; Little, D.; Gissen, P.; Collinson, L.; Clarke, D. J.; Kunath, T.; Klenerman, D.; Abramov, A. Y.; Horrocks, M. H.; Gandhi, S.
10.1101/2022.06.07.494932 — neuroscience — Posted on 2022-06-09
2941 Lymphoma cells are circulating in blood of Enzootic Bovine Leukosis and clonality value of virus-infected cells is a useful information for the diagnostic test
Hossain, B. M.; Kobayashi, T.; Makimoto, S.; Matsuo, M.; Nishikaku, K.; Tan, B. J. Y.; Rahman, A.; Rajib, S. A.; Sugata, K.; Ohnuki, N.; Saito, M.; Inenaga, T.; Imakawa, K.; Satou, Y.
10.1101/2022.06.07.495053 — zoology — Posted on 2022-06-09
2942 Chromosome-level genome assembly of Rorippa aquatica revealed its allotetraploid origin and mechanisms of heterophylly upon submergence
Sakamoto, T.; Ikeamtsu, S.; Nakayama, H.; Mandakova, T.; Gohari, G.; Sakamoto, T.; Li, G.; Hou, H.; Matsunaga, S.; Lysak, M. A.; Kimura, S.
10.1101/2022.06.06.494894 — plant biology — Posted on 2022-06-09
2943 Root architecture plasticity in response to endoparasitic cyst nematodes is mediated by damage signaling
Guarneri, N.; Willig, J.-J.; Sterken, M. G.; Zhou, W.; Hasan, M. S.; Grundler, F. M. W.; Willemsen, V.; Goverse, A.; Smant, G.; Lozano-Torres, J. L.
10.1101/2022.06.07.495098 — plant biology — Posted on 2022-06-09
2947 Promoter sequence and architecture determine expression variability and confer robustness to genetic variants
Einarsson, H.; Salvatore, M.; Vaagenso, C.; Alcaraz, N.; Bornholdt Lange, J.; Rennie, S.; Andersson, R.
10.1101/2021.10.29.466407 — genomics — Posted on 2022-06-09
2949 Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis
Mund, M.; Tschanz, A.; Wu, Y.-L.; Frey, F.; Mehl, J. L.; Kaksonen, M.; Avinoam, O.; Schwarz, U. S.; Ries, J.
10.1101/2021.10.12.463947 — cell biology — Posted on 2022-06-09
2950 IntAct: a non-disruptive internal tagging strategy to study actin isoform organization and function
van Zwam, M. C.; Bosman, W.; van Straaten, W.; Weijers, S.; Seta, E.; Joosten, B.; van den Dries, K.
10.1101/2021.10.25.465733 — cell biology — Posted on 2022-06-09
2951 Nano3P-seq: transcriptome-wide analysis of gene expression and tail dynamics using end-capture nanopore cDNA sequencing
Begik, O.; Diensthuber, G.; Liu, H.; Delgado-Tejedor, A.; Kontur, C.; Niazi, A. M.; Valen, E.; Giraldez, A. J.; Beaudoin, J.-D.; Mattick, J. S.; Novoa, E. M.
10.1101/2021.09.22.461331 — molecular biology — Posted on 2022-06-09
2953 Generating parallel representations of position and identity in the olfactory system
Taisz, I.; Dona, E.; Münch, D.; Bailey, S. N.; Morris, B. J.; Meechan, K. I.; Stevens, K. M.; Varela, I.; Gkantia, M.; Schlegel, P.; Ribeiro, C.; Jefferis, G. S. X. E.; Galili, D. S.
10.1101/2022.05.13.491877 — neuroscience — Posted on 2022-06-09
2954 A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation
Shaw, I. W.; Kirkwood, P. M.; Rebourcet, D.; Cousins, F. L.; Ainslie, R. J.; Livingstone, D. E. W.; Smith, L. B.; Saunders, P. T. K.; Gibson, D. A.
10.1101/2022.05.30.493728 — physiology — Posted on 2022-06-09
2959 Genomic Insights of Bruneian Malays
Azmi, M.; Chen, L.; Idris, A.; Lu, Z. H.
10.1101/2022.06.01.492266 — genomics — Posted on 2022-06-09
2962 Reconstructing the cascade of language processing in the brain using the internal computations of a transformer-based language model
Kumar, S.; Sumers, T. R.; Yamakoshi, T.; Goldstein, A.; Hasson, U.; Norman, K. A.; Griffiths, T. L.; Hawkins, R. D.; Nastase, S. A.
10.1101/2022.06.08.495348 — neuroscience — Posted on 2022-06-09
2963 The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit
Zhuang, Q.; Qiao, L.; Xu, L.; Yao, S.; Chen, S.; Zheng, X.; Li, J.; Fu, M.; Li, K.; Vatansever, D.; Ferraro, S.; Kendrick, K. M.; Becker, B.
10.1101/2022.05.26.493546 — neuroscience — Posted on 2022-06-09
2967 Targeting ATP12A, a non-gastric proton pump alpha subunit, for idiopathic pulmonary fibrosis treatment
Abdelgied, M.; Uhl, K.; Chen, O. G.; Schultz, C.; Tripp, K.; Peraino, A. M.; Paithankar, S.; Chen, B.; Kakazu, M. T.; Bahena, A. C.; Jager, T. E.; Lawson, C.; Chesla, D. W.; Pestov, N.; Modyanov, N. N.; Prokop, J.; Neubig, R. R.; Uhal, B. D.; Girgis, R. E.; Li, X.
10.1101/2022.06.08.495330 — cell biology — Posted on 2022-06-08
2969 Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis
Ma, S.; Dubin, A. E.; Romero, L. O.; Loud, M.; Salazar, A.; Wang, Y.; Chesler, A.; Wilkinson, K. A.; Vasquez, V.; Marshall, K. L.; Patapoutian, A.
10.1101/2022.06.07.495164 — neuroscience — Posted on 2022-06-08
2970 Endocytosis at Extremes: Formation and Internalization of Giant Clathrin-coated Pits Under Elevated Membrane Tension
Akatay, A. A.; Wu, T.; Djakbarova, U.; Thompson, C.; Cocucci, E.; Zandi, R.; Rudnick, J.; Kural, C.
10.1101/2022.06.07.495153 — biophysics — Posted on 2022-06-08
2971 BioImage Model Zoo: A Community-Driven Resource for Accessible Deep Learning in BioImage Analysis
Ouyang, W.; Beuttenmueller, F.; Gomez-de-Mariscal, E.; Pape, C.; Burke, T.; Garcia-Lopez-de-Haro, C.; Russell, C.; Moya-Sans, L.; de-la-Torre-Gutierrez, C.; Schmidt, D.; Kutra, D.; Novikov, M.; Weigert, M.; Schmidt, U.; Bankhead, P.; Jacquemet, G.; Sage, D.; Henriques, R.; Munoz-Barrutia, A.; Lundberg, E.; Jug, F.; Kreshuk, A.
10.1101/2022.06.07.495102 — bioinformatics — Posted on 2022-06-08
2972 The lingering effects of Neanderthal introgression on human complex traits
Wei, X.; Robles, C.; Pazokitoroudi, A.; Ganna, A.; Gusev, A.; Durvasula, A.; Gazal, S.; Loh, P.-R.; Reich, D.; Sankararaman, S.
10.1101/2022.06.07.495223 — genetics — Posted on 2022-06-08
2973 Monitoring rapid evolution of plant populations at scale with Pool-Sequencing
Czech, L.; Peng, Y.; Spence, J. P.; Lang, P. L. M.; Bellagio, T.; Hildebrandt, J.; Fritschi, K.; Schwab, R.; Rowan, B.; GrENE-net consortium, ; Weigel, D.; Scheepens, J. F.; Vasseur, F.; Exposito-Alonso, M.
10.1101/2022.02.02.477408 — evolutionary biology — Posted on 2022-06-08
2974 Existing caribou habitat and demographic models are poorly suited for Ring of Fire impact assessment: A roadmap for improving the usefulness, transparency, and availability of models for conservation
Dyson, M. E.; Endicott, S.; Simpkins, C.; Turner, J. W.; Avery-Gomm, S.; Johnson, C. A.; Leblond, M.; Neilson, E.; Rempel, R. S.; Wiebe, P.; Baltzer, J. L.; Stewart, F. E. C.; Hughes, J.
10.1101/2022.06.01.494350 — ecology — Posted on 2022-06-08
2975 Effect of host-switching on the eco-evolutionary patterns of parasites
D'Bastiani, E.; Princepe, D.; Campiao, K. M.; Darcie Marquitti, F. M.; Boeger, W. A.; Araujo, S. B. L.
10.1101/2021.11.27.470149 — ecology — Posted on 2022-06-08
2976 Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
Doimo, M.; Abrahamsson, S.; L'Hote, V.; Ndi, M.; Das, R. N.; Aasumets, K.; Berner, A.; Goffart, S.; Pohjoismäki, J. L. O.; Davila, M.; Chorell, E.; Wanrooij, S.
10.1101/2022.06.08.495283 — cell biology — Posted on 2022-06-08
2980 Heterogeneity in viral replication dynamics shapes the antiviral response
Bruurs, L. J. M.; Müller, M.; Schipper, J. G.; Rabouw, H. H.; Boersma, S.; van Kuppeveld, F. J. M.; Tanenbaum, M. E.
10.1101/2022.06.08.495262 — immunology — Posted on 2022-06-08
2982 Maternal diet disrupts the placenta-brain axis in a sex-specific manner
Ceasrine, A. M.; Devlin, B. A.; Bolton, J. L.; Green, L. A.; Jo, Y. C.; Huynh, C.; Patrick, B.; Washington, K.; Sanchez, C. L.; Joo, F.; Campos-Salazar, A. B.; Lockshin, E. R.; Kuhn, C.; Murphy, S. K.; Simmons, L. A.; Bilbo, S. D.
10.1101/2021.11.12.468408 — neuroscience — Posted on 2022-06-08
2983 The OPAQUE1/DISCORDIA2 myosin XI is required for phragmoplast guidance during asymmetric cell division in maize
Nan, Q.; Liang, H.; Mendoza, J.; Liu, L.; Fulzele, A.; Wright, A. J.; Bennett, E. J.; Rasmussen, C.; Facette, M. R.
10.1101/2021.08.29.458084 — plant biology — Posted on 2022-06-08
2984 A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8
Tarasov, K. V.; Chakir, K.; Riordon, D. R.; Lyashkov, A. E.; Ahmet, I.; Perino, M. G.; Silvester, A. J.; Zhang, J.; Wang, M.; Lukyanenko, Y. O.; Qu, J.-H.; Barrera, M. C.-R.; Juhaszova, M.; Tarasova, Y. S.; Ziman, B.; Telljohann, R.; Kumar, V.; Ranek, M.; Lammons, J.; Beshkov, R.; deCabo, R.; Jun, S.; Keceli, G.; Gupta, A.; Yang, D.; Aon, M. A.; Adamo, L.; Morrell, C. H.; Otu, W.; Carroll, C.; Chambers, S.; Paolocci, N.; Huynh, T.; Pacak, K.; Weiss, R.; Field, L.; Sollott, S. S.; Lakatta, E. G.
10.1101/2022.05.20.491883 — physiology — Posted on 2022-06-08
2985 Genomic characteristics and clinical significance of CD56+ Circulating Tumor Cells in Small Cell Lung Carcinoma
Ricordel, C.; Chaillot, L.; Vlachavas, E.-I.; Logotheti, M.; Jouannic, A.; Desvallees, T.; Lecuyer, G.; Aubry, M.; Kontogianni, G.; Mastrokalou, C.; Jouan, F.; Jarry, U.; Corre, R.; Le Guen, Y.; Guillaudeux, T.; Lena, H.; Chatziioannou, A.; Pedeux, R.
10.1101/2022.04.30.487775 — cancer biology — Posted on 2022-06-08
2986 Mechanistic insights into global suppressors of protein folding defects
Chattopadhyay, G.; Bhowmick, J.; Manjunath, K.; Ahmed, S.; Goyal, P.; Varadarajan, R.
10.1101/2021.11.18.469098 — biophysics — Posted on 2022-06-08
2991 The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
Strike, L. T.; Hansell, N. K.; Chuang, K.-H.; Miller, J. L.; de Zubicaray, G. I.; Thompson, P. M.; McMahon, K. L.; Wright, M. J.
10.1101/2022.05.19.492753 — neuroscience — Posted on 2022-06-08
2993 The crosstalk between DNA-PK and cGAS drives tumor immunogenicity
Taffoni, C.; Marines, J.; Chamma, H.; Saccas, M.; Bouzid, A.; Guha, S.; Chaves Valadao, A.-L.; Polak, K.; Del Rio, M.; Gongora, C.; Pineau, D.; Hugnot, J.-P.; Kissa, K.; Fontenille, L.; Blanchet, F. P.; Vila, I. K.; Laguette, N.
10.1101/2022.06.08.495278 — cancer biology — Posted on 2022-06-08
2996 Immunomodulatory effect of mycobacterial outer membrane vesicles coated nanoparticles
George, E.; Goswami, A.; Lodhiya, T.; Padwal, P.; Iyer, S.; Gauttam, I.; Sethi, L.; Jeyasankar, S.; Sharma, P. R.; Dravid, A. A.; Mukherjee, R.; Agarwal, R.
10.1101/2022.06.07.495204 — bioengineering — Posted on 2022-06-08
3000 Benzo(a)pyrene regulates chaperone-mediated autophagy via heat shock protein 90
Su, M.; Zhou, S.; Li, J.; Lin, N.; Chi, T.; Zhang, M.; Lv, X.; Hu, Y.; Bai, T.; Chang, F.
10.1101/2022.06.08.495280 — biochemistry — Posted on 2022-06-08
3002 A Modular Chemoenzymatic Approach to C14-Functionalized Steroids
Song, F.; Zheng, M.; Wang, J.; Liu, H.; Lin, Z.; Liu, B.; Deng, Z.; Zhou, Q.; Qu, X.
10.1101/2022.06.08.495276 — biochemistry — Posted on 2022-06-08
3003 A genomic platform for surveillance and antigen discovery in Plasmodium spp. using long-read amplicon sequencing
Plaza, D. F.; Zerebinski, J.; Broumou, I.; Lautenbach, M. J.; Ngasala, B.; Sundling, C.; Farnert, A.
10.1101/2022.06.08.495295 — genomics — Posted on 2022-06-08
3008 Matrin3 regulates cell proliferation and spindle dynamics by regulating CDC14B alternative splicing
Muys, B. R.; Shrestha, R. L.; Anastasakis, D. G.; Pongor, L.; Li, X. L.; Grammatikakis, I.; Polash, A.; Harris, C. C.; Aladjem, M. I.; Basrai, M. A.; Hafner, M.; Lal, A.
10.1101/2022.06.08.495349 — molecular biology — Posted on 2022-06-08
3015 Dynamic Phaeodactylum tricornutum Exometabolites Shape Surrounding Bacterial Communities
Brisson, V.; Swink, C.; Kimbrel, J.; Mayali, X.; Samo, T.; Kosina, S. M.; Thelen, M.; Northen, T. R.; Stuart, R. K.
10.1101/2022.06.08.495228 — microbiology — Posted on 2022-06-08
3017 Optimizing CpG spatial distribution with DNA origami for Th1-polarized therapeutic vaccination
Zeng, Y. C.; Young, O. J.; Wintersinger, C. M.; Anastassacos, F. M.; MacDonald, J. I.; Isinelli, G.; Dellacherie, M. O.; Sobral, M.; Bai, H.; Graveline, A.; Vernet, A.; Sanchez-Ventura, M.; Mulligan, K.; Choi, Y.-J.; Ferrante, T. C.; Keskin, D.; Wu, C.; Mooney, D.; Kwon, I.-C.; Ryu, J.-H.; Shih, W.
10.1101/2022.06.08.495340 — synthetic biology — Posted on 2022-06-08
3019 Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome
Mikhailova, A. A.; Shamanskiy, V.; Ushakova, K.; Mikhailova, A. G.; Oreshkov, S.; Knorre, D.; Tretiakov, E. O.; Overdevest, J. B.; Lukowski, S. W.; Liou, C.-W.; Lin, T.-K.; Kunz, W. S.; Reymond, A.; Mazunin, I.; Bazykin, G. A.; Gunbin, K.; Fellay, J.; Tanaka, M.; Khrapko, K.; Popadin, K.
10.1101/603282 — genetics — Posted on 2022-06-08
3021 Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants
Beavis, A.; Li, Z.; Briggs, K.; Diaz, M.; Wrobel, E.; Najera, M.; An, D.; Orr-Burks, N.; Murray, J.; Pati, P.; Huang, J.; Mousa, J. J.; Hao, L.; Hsiang, T.-Y.; Gale, M. J.; Harvey, S.; Tompkins, S. M.; Hogan, J.; Lafontaine, E.; Jin, H.; He, B.
10.1101/2022.06.07.495215 — microbiology — Posted on 2022-06-08
3022 SARS-CoV-2 spike protein induces long-term TLR4-mediated synapse and cognitive loss recapitulating Post-COVID syndrome
Fontes-Dantas, F. L.; Fernandes, G. G.; Gutman, E. G.; De Lima, E. V.; Antonio, L. S.; Hammerle, M. B.; Mota-Araujo, H. P.; Colodeti, L. C.; Araujo, S. M. B.; da Silva, T. N.; Duarte, L. A.; Salvio, A. L.; Pires, K. L.; Leon, L. A. A.; Vasconcelos, C. C. F.; Romao, L.; Savio, L. E. B.; Silva, J. L.; da Costa, R.; Clarke, J. R.; Da Poian, A. T.; Alves-Leon, S. V.; Passos, G. F.; Figueiredo, C. P.
10.1101/2022.06.07.495149 — neuroscience — Posted on 2022-06-08
3023 High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling
MacMillan, J. B.; Linington, R. G.; Hight, S. K.; Lokey, R. S.; Bray, W.; Kurita, K.; Shaikh, A.; Haeckl, J.; La, S.; Lohith, A.; McMillan, E. A.; White, M. A.; Clark, T. N.; Lee, J.; Carnevale, F.; Vaden, R. M.; Wei, S.
10.1101/748129 — pharmacology and toxicology — Posted on 2022-06-08
3024 Struct2Graph: A graph attention network for structure based predictions of protein-protein interactions
Baranwal, M.; Magner, A.; Saldinger, J.; Turali-Emre, E. S.; Elvati, P.; Kozarekar, S.; VanEpps, J. S.; Kotov, N.; Violi, A.; Hero, A. O.
10.1101/2020.09.17.301200 — bioinformatics — Posted on 2022-06-08
3029 Generating parallel representations of position and identity in the olfactory system
Taisz, I.; Dona, E.; Münch, D.; Bailey, S. N.; Morris, B. J.; Meechan, K. I.; Stevens, K. M.; Varela, I.; Gkantia, M.; Schlegel, P.; Ribeiro, C.; Jefferis, G. S. X. E.; Galili, D. S.
10.1101/2022.05.13.491877 — neuroscience — Posted on 2022-06-08
3030 Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors
Licciardello, M. P.; Zhang, C.; Le, A. T.; Doebele, R. C.; Clarke, P. A.; Workman, P.
10.1101/2022.06.08.495301 — cancer biology — Posted on 2022-06-08
3035 Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease
Stouffer, K.; Chen, C.; Kulason, S.; Xu, E.; Witter, M.; Ceritoglu, C.; Albert, M.; Mori, S.; Troncoso, J.; Tward, D. J.; Miller, M. I.
10.1101/2022.06.06.494859 — bioengineering — Posted on 2022-06-08
3041 Towards the Interpretability of Deep Learning Models for Multi-modal Neuroimaging: Finding Structural Changes of the Ageing Brain
Hofmann, S. M.; Beyer, F.; Lapuschkin, S.; Goltermann, O.; Markus, L.; Mueller, K.-R.; Villringer, A.; Samek, W.; Witte, A. V.
10.1101/2021.06.25.449906 — neuroscience — Posted on 2022-06-08
3044 Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes
Teo, J. D.; Marian, O. C.; Spiteri, A. G.; Nicholson, M.; Song, H.; Khor, J. X.; McEwen, H. P.; Piccio, L.; Fletcher, J.; King, N. J. C.; Murray, S. S.; Brüning, J. C.; Don, A. S.
10.1101/2022.05.29.493337 — neuroscience — Posted on 2022-06-08
3045 Activation of trace amine-associated receptor 1 (TAAR1) reduces alcohol drinking behaviors in mice
Frycz, B. A.; Nowicka, K.; Konopka, A.; Hoener, M. C.; Bulska, E.; Kaczmarek, L.; Stefaniuk, M.
10.1101/2022.06.02.494484 — neuroscience — Posted on 2022-06-08
3046 Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice.
Lee, S. M.; Muratalla, J.; Karimi, S.; Diaz-Ruiz, A.; Frutos, D.; Guzman, G.; Ramos-Molina, B.; Cordoba-Chacon, J.
10.1101/2022.06.06.494901 — physiology — Posted on 2022-06-08
3051 A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode
Zhao, D.; Liu, L.; Liu, X.; Zhang, J.; Yin, Y.; Luan, L.; Jiang, D.; Yang, X.; Li, L.; Xiong, H.; Xing, D.; Zheng, Q.; Xia, N.; Tao, Y.; Li, S.; Huang, H.
10.1101/2022.04.11.487660 — biochemistry — Posted on 2022-06-08
3055 Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection
Kurhade, C.; Zou, j.; Xia, H.; Liu, M.; Yang, Q.; Cutler, M.; Cooper, D.; Muik, A.; Sahin, U.; Jansen, K. U.; Ren, P.; Xie, X.; Swanson, K. A.; Shi, P.-Y.
10.1101/2022.06.05.494889 — microbiology — Posted on 2022-06-08
3056 The Brain/MINDS Marmoset Connectivity Atlas: Exploring bidirectional tracing and tractography in the same stereotaxic space
Skibbe, H.; Rachmadi, M. F.; Nakae, K.; Gutierrez, C. E.; Hata, J.; Tsukada, H.; Poon, C.; Doya, K.; Majka, P.; Rosa, M. G.; Okano, H.; Yamamori, T.; Ishii, S.; Reisert, M.; Watakabe, A.
10.1101/2022.06.06.494999 — neuroscience — Posted on 2022-06-08
3057 High salt induces cognitive impairment via the angiotensin II-AT1 and prostaglandin E2-EP1 systems
Kubota, H.; Kunisawa, K.; Wulaer, B.; Hasegawa, M.; Kurahashi, H.; Sakata, T.; Tezuka, H.; Kugita, M.; Nagao, S.; Nagai, T.; Furuyashiki, T.; Narumiya, S. S.; Saito, K.; Nabeshima, T.; Mouri, A.
10.1101/2022.06.06.495007 — neuroscience — Posted on 2022-06-08
3059 Mitigating the Bfl-1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs
Yoon, S.-S.; Park, E.; Lee, C.; Park, J.; Liu, J.; Hong, J.; Shin, D.-Y.; Byun, J. M.; Yun, H.; Koh, Y.
10.1101/2022.03.28.486020 — cancer biology — Posted on 2022-06-08
3061 Learning about threat from friends and strangers is equally effective: an fMRI study on observational fear conditioning
Kazmierowska, A. M.; Szczepanik, M.; Wypych, M.; Drozdziel, D.; Marchewka, A.; Michalowski, J. M.; Olsson, A.; Knapska, E.
10.1101/2021.09.20.461036 — neuroscience — Posted on 2022-06-08
3062 Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers
Mugarza, E.; van Maldegem, F.; Boumelha, J.; Moore, C.; Rana, S.; Sopena, M. L.; East, P.; Ambler, R.; Anastasiou, P.; Clavijo, P. R.; Valand, K.; Cole, M.; Molina-Arcas, M.; Downward, J.
10.1101/2021.10.18.464819 — cancer biology — Posted on 2022-06-08
3063 Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Ruppel, A.; Woerthmueller, D.; Misiak, V.; Kelkar, M.; Wang, I.; Moreau, P.; Mery, A.; Revilloud, J.; Charras, G.; Cappello, G.; Boudou, T.; Schwarz, U. S.; Balland, M.
10.1101/2022.06.01.494332 — biophysics — Posted on 2022-06-08
3064 Inter-layer and inter-subject variability of circadian gene expression in human skin
del Olmo, M.; Spoerl, F.; Korge, S.; Juerchott, K.; Felten, M.; Grudziecki, A.; de Zeeuw, J.; Nowozin, C.; Reuter, H.; Blatt, T.; Herzel, H.; Kunz, D.; Kramer, A.; Ananthasubramaniam, B.
10.1101/2022.06.03.494693 — bioinformatics — Posted on 2022-06-08
3066 A comprehensive map of human glucokinase variant activity
Gersing, S.; Cagiada, M.; Gebbia, M.; Gjesing, A. P.; Cote, A. G.; Seesankar, G.; Li, R.; Tabet, D.; Stein, A.; Gloyn, A. L.; Hansen, T.; Roth, F.; Lindorff-Larsen, K.; Hartmann-Petersen, R.
10.1101/2022.05.04.490571 — genetics — Posted on 2022-06-08
3067 Moderate ART resistance mutations with low fitness cost in malaria parasites from Africa
Behrens, H. M.; Schmidt, S.; Peigney, D.; May, J.; Maïga-Ascofare, O.; Spielmann, T.
10.1101/2022.05.13.491767 — microbiology — Posted on 2022-06-08
3068 Evolutionary shaping of human brain dynamics
Pang, J. C.; Rilling, J. K.; Roberts, J. A.; van den Heuvel, M. P.; Cocchi, L.
10.1101/2022.06.07.495189 — neuroscience — Posted on 2022-06-08
3069 Reduced resilience of brain state transitions in patients with anti-N-Methyl-D-Aspartate receptor encephalitis
von Schwanenflug, N.; Ramirez-Mahaluf, J. P.; Krohn, S.; Romanello, A.; Heine, J.; Pruess, H.; Crossley, N. K.; Finke, C.
10.1101/2022.01.24.477081 — neuroscience — Posted on 2022-06-08
3071 Epistasis between promoter activity and coding mutations shapes gene evolvability
Caballero, A. F. C.; Gagnon-Arsenault, I.; Dube, A. K.; Despres, P. C.; Kumar, P.; Lafontaine, K.; Pelletier, J. N.; Landry, C. R.
10.1101/2022.06.07.495002 — evolutionary biology — Posted on 2022-06-08
3076 AMPK is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice
Raun, S. H.; Ali, M. S.; Han, X.; Henriquez-Olguin, C.; Pham, T. C. P.; Knudsen, J. R.; Willemsen, A. C. H.; Larsen, S.; Jensen, T. E.; Langen, R.; Sylow, L.
10.1101/2022.06.07.495096 — molecular biology — Posted on 2022-06-07
3077 Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets
Ruberto, A. A.; Maher, S. P.; Vantaux, A.; Joyner, C. J.; Bourke, C.; Balan, B.; Jex, A.; Mueller, I.; Witkowski, B.; Kyle, D. E.
10.1101/2022.02.01.478648 — microbiology — Posted on 2022-06-07
3080 The Genetic Architecture of Morphological Scaling
Wilcox, A. S.; Vea, I. M.; Frankino, W. A.; Shingleton, A.
10.1101/2022.06.07.495193 — genetics — Posted on 2022-06-07
3082 Coordinated multiplexing of information about separate objects in visual cortex
Jun, N. Y.; Ruff, D. A.; Kramer, L. E.; Bowes, B.; Tokdar, S. T.; Cohen, M. R.; Groh, J. M.
10.1101/777912 — neuroscience — Posted on 2022-06-07
3083 Early Detection of Tau Pathology
Parekh, P. A.; Badachhape, A.; Mu, Q.; Bhavane, R.; Srivastava, M.; Bhandari, P.; Devkota, L.; Eriksen, J.; Tanifum, E.; Ghaghada, K.; Annapragada, A.
10.1101/2021.05.14.444233 — neuroscience — Posted on 2022-06-07
3087 vcferr: Development, Validation, and Application of a SNP Genotyping Error Simulation Framework
Nagraj, V. P.; Scholz, M.; Jessa, S.; Ge, J.; Woerner, A. E.; Huang, M.; Budowle, B.; Turner, S. D.
10.1101/2022.03.28.485853 — bioinformatics — Posted on 2022-06-07
3088 An assessment of bioinformatics tools for the detection of human endogenous retroviral insertions in short-read genome sequencing data
Bowles, H.; Kabiljo, R.; Jones, A.; Al Khleifat, A.; Quinn, J. P.; Dobson, R. J.; Swanson, C. M.; Al-Chalabi, A.; Iacoangeli, A.
10.1101/2022.02.18.481042 — bioinformatics — Posted on 2022-06-07
3091 The genomics of linkage drag in sunflower
Huang, K.; Jahani, M.; Gouzy, J.; Legendre, A.; Carrere, S.; Lazaro-Guevara, J. M.; Segovia, E. G. G.; Todesco, M.; Mayjonade, B.; Rodde, N.; Cauet, S.; Dufau, I.; Staton, S. E.; Pouilly, N.; Boniface, M.-C.; Tapy, C.; Mangin, B.; Duhnen, A.; Gautier, V.; Poncet, C.; Donnadieu, C.; Mandel, T.; Hubner, S.; Burke, J. M.; Vautrin, S.; Bellec, A.; Owens, G. L.; Langlade, N.; Munos, S.; Rieseberg, L. H.
10.1101/2022.06.07.495047 — genomics — Posted on 2022-06-07
3094 A pandemic clonal lineage of the wheat blast fungus
Latorre, S. M.; Were, V. M.; Foster, A. J.; Langner, T.; Malmgren, A.; Harant, A.; Asuke, S.; Reyes-Avila, S.; Gupta, D. R.; Jensen, C.; Ma, W.; Mahmud, N. U.; Mehebub, S.; Mulenga, R. M.; Muzahid, A. N. M.; Paul, S.; Rabby, F. S. M.; Raha, A. A. M.; Ryder, L.; Shrestha, R.-K.; Sichilima, S.; Soanes, D. M.; Singh, P. K.; Bentley, A. R.; Saunders, D. G. O.; Tosa, Y.; Croll, D.; Lamour, K. H.; Islam, T.; Tembo, B.; Win, J.; Talbot, N. J.; Burbano, H. A.; Kamoun, S.
10.1101/2022.06.06.494979 — evolutionary biology — Posted on 2022-06-07
3099 Histone malonylation is regulated by SIRT5 and KAT2A
Zhang, R.; Bons, J.; Bielska, O.; Carrico, C.; Rose, J.; Heckenbach, I.; Scheibye-Knudsen, M.; Schilling, B.; Verdin, E.
10.1101/2022.06.07.495150 — molecular biology — Posted on 2022-06-07
3100 Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila
Kerkhofs, K.; Garg, J.; Fafard-Couture, Étienne; Abou Elela, S.; Scott, M. S.; Pearlman, R. E.; Bayfield, M. A.
10.1101/2022.06.07.494954 — molecular biology — Posted on 2022-06-07
3103 Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis
Cowan, M. N.; Kovacs, M. A.; Sethi, I.; Babcock, I. W.; Still, K.; Batista, S. J.; O'Brien, C. A.; Thompson, J. A.; Sibley, L. A.; Labuzan, S. A.; Harris, T. H.
10.1101/2022.06.06.494970 — immunology — Posted on 2022-06-07
3105 Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin-regulating protein VASP
Cakir, Z.; Lord, S. J.; Jimenez-Morales, D.; Jang, G. M.; Polacco, B. J.; Eckhardt, M.; Newton, B. W.; Zhou, Y.; Orr, A. L.; Johnson, J. R.; Mullins, D.; Krogan, N. J.; Mahley, R. W.; Swaney, D. L.
10.1101/2022.06.06.495052 — neuroscience — Posted on 2022-06-07
3108 Programmable Mixed-Signal Biocomputers in Mammalian Cells
Letendre, J. H.; Weinberg, B. H.; Mendes, M.; Marano, J. M.; Benman, W. K. J.; Petherbridge, R.; Drezek, K.; Koplik, S. E.; Pineiro, A.; Wong, W.
10.1101/2022.06.07.495130 — synthetic biology — Posted on 2022-06-07
3109 The VEGAS platform is not suitable for mammalian directed evolution
Denes, C. E.; Cole, A. J.; Tran, M. T. N.; Khalid, M. K. N. M.; Hewitt, A. W.; Hesselson, D.; Neely, G. G.
10.1101/2022.06.07.495067 — synthetic biology — Posted on 2022-06-07
3112 The Arabidopsis D27like1 is a novel Isomerase that Contributes to SL Biosynthesis and Negatively Impacts ABA Level
Yang, Y.; Abuauf, H.; Song, S.; Wang, J. Y.; Alagoz, Y.; Moreno Beltran, J. C.; Mi, J.; Ablazov, A.; Jamil, M.; Ali, S.; Zheng, X.; Balakrishna, A.; Blilou, I.; Al-Babili, S.
10.1101/2022.06.07.495147 — plant biology — Posted on 2022-06-07
3114 Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex
Ramirez-Franco, J.; Azzaz, F.; Sangiardi, M.; Ferracci, G.; Youssouf, F.; Popoff, M. R.; Seagar, M.; Leveque, C.; Fantini, J.; EL FAR, O.
10.1101/2021.10.18.464377 — pharmacology and toxicology — Posted on 2022-06-07
3115 A genetically engineered phage-based nanomaterial for detecting bacteria with magnetic resonance imaging
Borg, R. E.; Ozbakir, H. F.; Xu, B.; Li, E.; Fang, X.; PENG, H.; Chen, I. A.; Mukherjee, A.
10.1101/2022.06.07.495091 — bioengineering — Posted on 2022-06-07
3116 ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation
Choi, W. H.; Yun, Y.; Byun, I.; Lee, S.; Sim, J.; Levi, S.; Kim, S.; Park, S. H.; Jun, J.; Kim, K. P.; Kwon, Y. T.; Han, D.; Chiba, T.; Seok, C.; Glickman, M. H.; Lee, M. J.
10.1101/2022.06.06.495046 — biochemistry — Posted on 2022-06-07
3118 Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system
Sarma, P.; Yoon, H.-J.; Carino, C. M.; S., D.; Banerjee, R.; Yun, Y.; Ji, J.; Min, K.; Pandey, S.; Dwivedi-Agnihotri, H.; Rui, X.; Cao, Y.; Kawakami, K.; Chen, Y.-C.; Kumari, P.; Luker, K. E.; Yadav, M. K.; Ranjan, A.; Chaturvedi, M.; Maharana, J.; Baidya, M.; Yadav, P. N.; Luker, G. D.; Laporte, S. A.; Chen, X.; Inoue, A.; Lee, H. H.; Shukla, A. K.
10.1101/2022.06.06.494935 — biochemistry — Posted on 2022-06-07
3119 A cell-permeant nanobody-based degrader that induces fetal hemoglobin
Shen, F.; Zheng, G.; Setegne, M.; Tenglin, K.; Izada, M.; Xie, H.; Zhai, L.; Orkin, S. H.; Dassama, L. M. K.
10.1101/2022.06.07.495197 — biochemistry — Posted on 2022-06-07
3120 Nirmatrelvir Resistant SARS-CoV-2 Variants with High Fitness in Vitro
Zhou, Y.; Gammeltoft, K. A.; Ryberg, L. A.; Pham, L. V.; Fahnoe, U.; Binderup, A.; Hernandez, C. R. D.; Offersgaard, A.; Fernandez-Antunez, C.; Peters, G. H. J.; Ramirez, S.; Bukh, J.; Gottwein, J. M.
10.1101/2022.06.06.494921 — microbiology — Posted on 2022-06-07
3124 Diagnosis and early prediction of lymphoma using high-throughput clonality analysis of bovine leukemia virus-infected cells
Okagawa, T.; Shimakura, H.; Konnai, S.; Saito, M.; Matsudaira, T.; Nao, N.; Yamada, S.; Murakami, K.; Maekawa, N.; Murata, S.; Ohashi, K.
10.1101/2022.06.06.495041 — microbiology — Posted on 2022-06-07
3126 Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out
Dechering, K. J.; Timmerman, M.; Rensen, K.; Koolen, K. M. J.; Honarnejad, S.; Vos, M.; Huijs, T.; Henderson, R.; Chenu, E.; Laleu, B.; Montefiore, B. C.; Segall, M. D.; Mills, J. E. J.; Guantai, E. M.; Duffy, J.; Duffey, M.
10.1101/2022.06.07.495126 — microbiology — Posted on 2022-06-07
3127 The substitutions L50F, E166A and L167F in SARS-CoV-2 3CLpro are selected by a protease inhibitor in vitro and confer resistance to nirmatrelvir
Jochmans, D.; Liu, C.; Donckers, K.; Stoycheva, A.; Boland, S.; Stevens, S. K.; De Vita, C.; Vanmechelen, B.; Maes, P.; Trüeb, B. S.; Ebert, N.; Thiel, V.; De Jonghe, S.; Vangeel, L.; Bardiot, D.; Jekle, A.; Blatt, L. M.; Beigelman, L.; Symons, J. A.; Raboisson, P.; Chaltin, P.; Marchand, A.; Neyts, J.; Deval, J.; Vandyck, K.
10.1101/2022.06.07.495116 — microbiology — Posted on 2022-06-07
3128 Development of an Escape-resistant SARS CoV-2 Neutralizing Synthetic Nanobody
Dormeshkin, D.; Shapira, M.; Dubovik, S.; Kavaleuski, A.; Katsin, M.; Migas, A.; Meleshko, A.; Semyonov, S.
10.1101/2022.06.07.495065 — synthetic biology — Posted on 2022-06-07
3129 Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks
Ortiz, A. T.; Kendall, M.; Storey, N.; Hatcher, J.; Dunn, H.; Roy, S.; Williams, R.; Williams, C.; Goldstein, R. A.; Didelot, X.; Harris, K.; Breuer, J.; Grandjean, L.
10.1101/2022.06.07.495142 — evolutionary biology — Posted on 2022-06-07
3130 Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents
Sommerfeld, L. C.; Holmes, A. P.; Yu, T. Y.; O'Shea, C.; Kavanagh, D. M.; Pike, J. A.; Wright, T.; Syeda, F.; Aljehani, A.; Kew, T.; Cardoso, V. R.; Kabir, S. N.; Hepburn, C.; Menon, P. M.; Broadway-Stringer, S.; O'Reilly, M.; Witten, A.; Fortmueller, L.; Lutz, S.; Kulle, A.; Gkoutos, G. V.; Pavlovic, D.; Arlt, W.; Lavery, G. G.; Steeds, R.; Gehmlich, K.; Stoll, M.; Kirchhof, P.; Fabritz, L.
10.1101/2022.06.03.494748 — molecular biology — Posted on 2022-06-07
3132 Predicting clinical outcomes of SARS-CoV-2 drug treatments with a high throughput human airway on chip platform
Fisher, C. R.; Medie, F. M.; Luu, R. J.; Quezada, L. L.; Gaibler, R. B.; Mulhern, T. J.; Rubio, L. D.; Marr, E. E.; Gabriel, E. P.; Borenstein, J. T.; Gard, A. L.
10.1101/2022.06.07.495101 — microbiology — Posted on 2022-06-07
3133 Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection
Kurhade, C.; Zou, j.; Xia, H.; Liu, M.; Yang, Q.; Cutler, M.; Cooper, D.; Muik, A.; Sahin, U.; Jansen, K. U.; Ren, P.; Xie, X.; Shi, P.-Y.
10.1101/2022.06.05.494889 — microbiology — Posted on 2022-06-07
3135 Ifit2 regulates murine-coronavirus spread to the spinal cord white matter and its associated myelin pathology
Sharma, M.; Chakravarty, D.; Zalavadia, A.; Burrows, A.; Rayman, P.; Sharma, N.; Kenyon, L. C.; Bergmann, C.; Sen, G. C.; Das Sarma, J.
10.1101/2022.06.06.494972 — neuroscience — Posted on 2022-06-07
3138 Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends
Gonzalez, S. J.; Goldblum, R. R.; Vu, K. T.; Shoemaker, R.; Reid, T. A.; McClellan, M.; Gardner, M. K.
10.1101/2022.06.07.495114 — cell biology — Posted on 2022-06-07
3139 Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis
Pennacchio, F. A.; Poli, A.; Pramotton, F. M.; Lavore, S.; Rancati, I.; Cinquanta, M.; Vorselen, D.; Prina, E.; Romano, O. M.; Ferrari, A.; Piel, M.; Cosentino Lagomarsino, M.; Maiuri, P.
10.1101/2022.06.07.494975 — cell biology — Posted on 2022-06-07
3140 PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
LoMastro, G. M.; Drown, C. G.; Maryniak, A. L.; Jewett, C. E.; Strong, M. A.; Holland, A. J.
10.1101/2022.06.06.494981 — cell biology — Posted on 2022-06-07
3141 Parvovirus infection alters the nucleolar structure
Mattola, S.; Leclerc, S.; Hakanen, S.; Aho, V.; Parrish, C. R.; Vihinen-Ranta, M.
10.1101/2022.06.07.495090 — cell biology — Posted on 2022-06-07
3142 Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin-regulating protein VASP
Cakir, Z.; Lord, S. J.; Jimenez-Morales, D.; Jang, G. M.; Polacco, B. J.; Eckhardt, M.; Newton, B. W.; Zhou, Y.; Orr, A. L.; Johnson, J. R.; Mullins, D.; Krogan, N. J.; Swaney, D. L.; Mahley, R. W.
10.1101/2022.06.06.495052 — neuroscience — Posted on 2022-06-07
3145 E-cadherin mediated Apical Membrane Initiation Site localisation
Liang, X.; Weberling, A.; Hii, C. Y.; Zernicka-Goetz, M.; Buckley, C. E.
10.1101/2021.11.30.470571 — developmental biology — Posted on 2022-06-07
3155 The genomic and bioclimatic characterization of Ethiopian barley (Hordeum vulgare L.) unveils challenges and opportunities to adapt to a changing climate
Lakew, B. F.; Caproni, L.; Kassaw, S. A.; Miculan, M.; Seid Ahmed, J.; Grazioli, S.; Kidane, Y. G.; Fadda, C.; Pe', M. E.; Dell'Acqua, M.
10.1101/2022.05.16.492093 — genetics — Posted on 2022-06-07
3156 PCDH7 Promotes Cell Migration by Regulating Myosin Activity
Qureshi, M. H.; Cinko, M. T.; Bayraktar, H.; Akkaya, C.; Kamacioglu, A.; Uretmen, Z. C.; Bozluolcay, E.; Ozlu, N.
10.1101/2021.09.21.460794 — cell biology — Posted on 2022-06-07
3158 Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: impact of his-tagging and carotenoid type.
Wilson, A.; Andreeva, E. A.; Nizinski, S.; Talbot, L.; Hartmann, E.; Schlichting, I.; Burdzinski, G.; Sliwa, M.; KIRILOVSKY, D.; Colletier, J.-P.
10.1101/2022.01.04.474796 — biophysics — Posted on 2022-06-07
3165 Adaptation to starvation requires a flexible circadian clockwork in Neurospora crassa
Szoke, A.; Sarkany, O.; Schermann, G.; Kapuy, O.; Diernfellner, A. C. R.; Brunner, M.; Gyöngyösi, N.; Kaldi, K.
10.1101/2022.06.06.494928 — cell biology — Posted on 2022-06-07
3169 Community assessment of methods to deconvolve cellular composition from bulk gene expression
White, B. S.; de Reynies, A.; Newman, A. M.; Waterfall, J. J.; Lamb, A.; Petitprez, F.; Yu, T.; Guo, X.; Valdeolivas, A.; Lin, Y.; Li, H.; Xiao, X.; Wang, S.; Zheng, F.; Yang, W.; Yu, R.; Guerrero-Gimenez, M. E.; Catania, C. A.; Lang, B. J.; Domanskyi, S.; Bertus, T. J.; Piermarocchi, C.; Monaco, G.; Caruso, F. P.; Ceccarelli, M.; Coller, J.; Maecker, H.; Duault, C.; Sokoohi, V.; Patel, S.; Liliental, J. E.; Simon, S.; Tumor Deconvolution DREAM Challenge consortium, ; Saez-Rodriguez, J.; Heiser, L. M.; Guinney, J.; Gentles, A. J.
10.1101/2022.06.03.494221 — bioinformatics — Posted on 2022-06-07
3176 A large-scale neural network training framework for generalized estimation of single-trial population dynamics
Keshtkaran, M. R.; Sedler, A. R.; Chowdhury, R. H.; Tandon, R.; Basrai, D.; Nguyen, S. L.; Sohn, H.; Jazayeri, M.; Miller, L. E.; Pandarinath, C.
10.1101/2021.01.13.426570 — neuroscience — Posted on 2022-06-07
3178 Cerebellar contributions to a brainwide network for flexible behavior
Verpeut, J. L.; Bergeler, S.; Kislin, M.; Townes, F. W.; Klibaite, U.; Dhanerawala, Z. M.; Hoag, A.; Jung, C.; Lee, J.; Pisano, T. J.; Seagraves, K. M.; Shaevitz, J. W.; Wang, S. S.- H.
10.1101/2021.12.07.471685 — neuroscience — Posted on 2022-06-07
3179 Towards generalizable prediction of antibody thermostability using machine learning on sequence and structure features
Harmalkar, A.; Rao, R. M.; Honer, J.; Deisting, W.; Anlahr, J.; Hoenig, A.; Czwikla, J.; Sienz-Widmann, E.; Rau, D.; Rice, A.; Riley, T. P.; Li, D.; Catterall, H. B.; Tinberg, C. E.; Gray, J. J.; Wei, K. Y.
10.1101/2022.06.03.494724 — bioinformatics — Posted on 2022-06-07
3180 Spatiotemporal atlas of the fetal brain depicts cortical developmental gradient in Chinese population
Xu, X.; Sun, C.; Sun, J.; Shi, W.; Shen, Y.; Zhao, R.; Luo, W.; Li, M.; Wang, G.; Wu, D.
10.1101/2022.05.09.491258 — bioengineering — Posted on 2022-06-07
3186 Latent functional diversity may accelerate microbial community responses to temperature fluctuations
Smith, T. P.; Mombrikotb, S.; Ransome, E.; Kontopoulos, D. - G.; Pawar, S.; Bell, T.
10.1101/2021.04.14.439774 — ecology — Posted on 2022-06-07
3187 Sexual coercion in a natural mandrill population
Smit, N.; Baniel, A.; Roura-Torres, B.; Amblard-Rambert, P.; Charpentier, M. J. E.; Huchard, E.
10.1101/2022.02.07.479393 — ecology — Posted on 2022-06-07
3190 SARS-CoV-2 S protein antagonizes type I interferon downstream signal pathway through interacting and attenuating phosphorylation of STAT1/STAT2
Ni, W.; Li, W.; Cai, Z.; Guo, W.; Zheng, Y.; Zhao, Y.; Wu, Z.; Liang, S.; Ye, J.; Guo, X.; Zhou, D.; Wu, X.; Zhou, C.; Tang, M.; Chen, Y.; Lan, K.; Zhou, L.; Xu, K.
10.1101/2022.06.06.494494 — microbiology — Posted on 2022-06-06
3191 The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm
Hamdorf, M.; Imhof, T.; Bailey-Elkin, B. A.; Betz, J.; Theobald, S. J.; Simonis, A.; Di Cristanziano, V.; Gieselmann, L.; Dewald, F.; Lehmann, C.; Augustin, M.; Klein, F.; Alcazar, M. A.; Rogisch, R.; Fabri, M.; Rybniker, J.; Goebel, H.; Stetefeld, J.; Brachvogel, B.; Cursiefen, C.; Koch, M.; Bock, F.
10.1101/2022.06.06.494969 — immunology — Posted on 2022-06-06
3193 Genomic Surveillance of SARS CoV2 in COVID-19 vaccinated healthcare workers in Lebanon.
Al Kalamouni, H.; Abou Hassan, F. F.; Bou Hamdan, M.; Page, A. J.; Lott, M.; Ghosn, N.; Rady, A.; Mahfouz, R.; Araj, G. F.; Dbaibo, G.; Zaraket, H.; Melhem, N. M.; Matar, G. M.
10.1101/2022.06.06.494965 — genomics — Posted on 2022-06-06
3194 Is the production of reactive oxygen and nitrogen species by macrophages associated with better infectious control in the experimental disseminated and pulmonary mucormycosis?
Santos, A. R. d.; Fraga-Silva, T. F.; Donanzam, D. d. F. A.; Finatto, A. C.; Marchetti, C.; Andrade, M. I.; Arruda, O. S. d.; Arruda, M. S. P. d.; Venturini, J.
10.1101/2022.06.06.494943 — immunology — Posted on 2022-06-06
3196 Integrating environmental DNA monitoring to inform eel (Anguilla anguilla) status in freshwaters at their easternmost range - A case study in Cyprus
Griffiths, N. P.; Wright, R. M.; Hänfling, B.; Bolland, J. D.; Drakou, K.; Sellers, G. S.; Zogaris, S.; Tziortzis, I.; Dörflinger, G.; Vasquez, M. I.
10.1101/2022.06.06.495005 — ecology — Posted on 2022-06-06
3203 MTaxi : A comparative tool for taxon identification of ultra low coverage ancient genomes
Atag, G.; Vural, K. B.; Kaptan, D.; Özkan, M.; Koptekin, D.; Saglıcan, E.; Dogramacı, S.; Köz, M.; Yılmaz, A.; Söylev, A.; Togan, I.; Somel, M.; Özer, F.
10.1101/2022.06.06.491147 — bioinformatics — Posted on 2022-06-06
3205 RNase E biomolecular condensates stimulate PNPase activity
Collins, M. J.; Tomares, D.; Schrader, J. M.; Childers, W. S.
10.1101/2022.06.06.495039 — biochemistry — Posted on 2022-06-06
3206 Proteome-wide microarray-based screening of PAR-binding proteins
Kang, B. G.; Kang, S.-U.; Kim, J. J.; Kwon, J.-S.; Gagne, J.-P.; Lee, S. Y.; Kim, S.; Sangwon, K. L.; Ha, S.; Jeong, J. S.; Lee, Y.-I.; Zhu, H.; Kim, D.; Poirier, G. G.; Kang, H. C.; Dawson, V. L.; Dawson, T. M.
10.1101/2022.06.06.494829 — biochemistry — Posted on 2022-06-06
3210 YAP/TAZ mediate TGFβ2-induced Schlemm's canal cell dysfunction
Li, H.; Perkumas, K. M.; Stamer, W. D.; Ganapathy, P. S.; Herberg, S.
10.1101/2022.06.06.494681 — cell biology — Posted on 2022-06-06
3211 Extracellular vesicle formation in Cryptococcus deuterogattii impacts fungal virulence and requires the NOP16 gene
Castelli, R.; Pereira, A.; Honorato, L.; Valdez, A.; de Oliveira, H. C.; Bazioli, J. M.; Garcia, A. W. A.; Klimeck, T.; Reis, F.; Staats, C. C.; Nimrichter, L.; Fill, t. P.; Rodrigues, M.
10.1101/2022.06.06.494995 — microbiology — Posted on 2022-06-06
3213 Efficient isolation of rare B cells using next-generation antigen barcoding
Hurtado, J.; Flynn, C.; Lee, J. H.; Salcedo, E.; Cottrell, C.; Skog, P. D.; Nemazee, D.; Schief, W. R.; Landais, E.; Sok, D.; Briney, B.
10.1101/2022.06.06.495029 — immunology — Posted on 2022-06-06
3215 Automated detection of extracellular action potentials from single neurons
Cheng, Z.; Guzman, E.; van der Molen, T.; Sharf, T.; Hansma, P.; Kosik, K. S.; Petzold, L.; Tovar, K. R.
10.1101/2022.06.06.494896 — neuroscience — Posted on 2022-06-06
3217 Improving the efficacy and accessibility of intracranial viral vector delivery in non-human primates
Griggs, D. J.; Garcia, A. D.; Au, W. Y.; Ojemann, W. K. S.; Johnson, A. G.; Ting, J. T.; Buffalo, E. A.; Yazdan-Shahmorad, A. T.
10.1101/2022.06.06.494543 — neuroscience — Posted on 2022-06-06
3218 Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques
Moshiri, A.; Fang, F.; Zhuang, P.; Huang, H.; Feng, X.; Li, L.; Dalal, R.; Hu, Y.
10.1101/2022.06.06.494980 — neuroscience — Posted on 2022-06-06
3219 Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS
Parameswaran, J.; Zhang, N.; Tilahun, K.; Pant, D. C.; Chilukuri, G.; Asress, S.; Banerjee, A.; Davis, E.; Schwartz, S. L.; Conn, G. L.; Bassell, G. J.; Jiang, J.
10.1101/2022.06.06.495030 — neuroscience — Posted on 2022-06-06
3220 Interpretable deep learning of myelin histopathology in age-related cognitive impairment
McKenzie, A. T.; Marx, G.; Koenigsberg, D.; Sawyer, M.; Iida, M. A.; Walker, J. M.; Richardson, T. E.; Campanella, G.; Attems, J.; McKee, A. C.; Stein, T. D.; Fuchs, T. J.; White, C. L.; The PART Working Group, ; Farrell, K.; Crary, J. F.
10.1101/2022.06.06.495016 — pathology — Posted on 2022-06-06
3229 Transposable elements drive intron gain in diverse eukaryotes
Gozashti, L.; Roy, S. W.; Thornlow, B.; Kramer, A.; Ares, M.; Corbett-Detig, R.
10.1101/2022.06.06.494994 — genomics — Posted on 2022-06-06
3231 Matrix fibroblast function during alveolarization is dependent on GATA6
Ushakumary, M. G.; Green, J.; Riccetti, M. R.; Na, C.-L.; Mohanraj, D.; Guo, M.; Perl, A.-K. T.
10.1101/2022.06.06.494950 — developmental biology — Posted on 2022-06-06
3233 Superinfection exclusion creates spatially distinct influenza virus populations
Sims, A.; Tornaletti, L. B.; Jasim, S.; Perillo, C.; Devlin, R.; Hirst, J.; Loney, C.; Wojtus, J.; Sloan, E.; Thorley, L.; Boutell, C.; Roberts, E.; Hutchinson, E.
10.1101/2022.06.06.494939 — microbiology — Posted on 2022-06-06
3234 Serum lipoproteins and lipoarabinomannan suppress the inflammatory response induced by the mycolactone toxin
Jakhar, S.; Lenz, K. D.; Jacobsen, D. E.; Kocheril, P. A.; Klosterman, K. E.; Mukundan, H.; Kubicek-Sutherland, J. Z.
10.1101/2022.06.06.494992 — microbiology — Posted on 2022-06-06
3235 Short superficial white matter and aging: a longitudinal multi-site study of 1,293 subjects and 2,711 sessions
Schilling, K. G.; Archer, D. B.; Yeh, F.-C.; Rheault, F.; Cai, L. Y.; Shafer, A.; Resnick, S. M.; Hohman, T.; Jefferson, A.; Anderson, A. W.; Kang, H.; Landman, B. A.
10.1101/2022.06.06.494720 — neuroscience — Posted on 2022-06-06
3237 Evaluation of Blood-Based Exosomes as Biomarkers for Aging-Related TDP-43 pathology
Winston, C. N.; Sukreet, S.; Lynch, H.; Lee, V. M. Y.; Wilcock, D. M.; Nelson, P. T.; Rissman, R. A.
10.1101/2022.06.03.487443 — neuroscience — Posted on 2022-06-06
3242 Technologically-Assisted Communication Attenuates Inter-Brain Synchrony
Schwartz, L.; Levy, J.; Endevelt-Shapira, Y.; Djalovski, A.; Hayut, O.; Dumas, G.; Feldman, R.
10.1101/2022.06.06.494185 — neuroscience — Posted on 2022-06-06
3248 Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis
Naderi, S.; Chen, P.; Murall, C. L.; Poujol, R.; Kraemer, S. A.; Pickering, B. S.; Sagan, S. M.; Shapiro, B. J.
10.1101/2022.06.02.494559 — genomics — Posted on 2022-06-06
3249 Origins and Evolution of Seasonal Human Coronaviruses
Otieno, J. R.; Cherry, J. L.; Spiro, D. J.; Nelson, M. I.; Trovao, N. S.
10.1101/2022.06.02.494567 — evolutionary biology — Posted on 2022-06-06
3250 Identification of genomic regions implicated in susceptibility to Schistosoma mansoni infection in a murine genetic model (backcross)
Hernandez-Goenaga, J.; Lopez-Aban, J.; Blanco-Gomez, A.; Vicente, B.; Burguillo, F. J.; Perez-Losada, J.; Muro, A.
10.1101/2022.06.06.494967 — pathology — Posted on 2022-06-06
3252 A uniquely stable trimeric model of SARS-CoV-2 spike transmembrane domain
Aliper, E. T.; Krylov, N. A.; Nolde, D. E.; Polyansky, A. A.; Efremov, R. G.
10.1101/2022.06.05.494856 — bioinformatics — Posted on 2022-06-06
3253 Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease
Hirose, Y.; Shindo, N.; Mori, M.; Onitsuka, S.; Isogai, H.; Hamada, R.; Hiramoto, T.; Ochi, J.; Takahashi, D.; Ueda, T.; Caaveiro, J. M. M.; Yoshida, Y.; Ohdo, S.; Matsunaga, N.; Toba, S.; Sasaki, M.; Orba, Y.; Sawa, H.; Sato, A.; Kawanishi, E.; Ojida, A.
10.1101/2022.06.05.494897 — biochemistry — Posted on 2022-06-06
3258 Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates
Guay-Vincent, M.-M.; Matte, C.; Berthiaume, A.-M.; Olivier, M.; Jaramillo, M.; Descoteaux, A.
10.1101/2022.06.06.494968 — microbiology — Posted on 2022-06-06
3260 Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang, X.; Wang, Z.; Niu, J.; Zhai, R.; Xue, X.; Wu, G.; Gong, M.; Zhao, L.; Zhang, C.
10.1101/2022.06.05.494898 — microbiology — Posted on 2022-06-06
3263 Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis
Sun, Y.; Yao, Z.; Chen, H.; Ye, Y.; Lyu, Y.; Broad, W.; Fournier, M.; Chen, G.; Hu, Y.; Mohammed, S.; Ling, Q.; Jarvis, R. P.
10.1101/2022.06.06.494369 — plant biology — Posted on 2022-06-06
3265 Comprehensive function annotation of metagenomes and microbial genomes using a deep learning-based method
Maranga, M.; Szczerbiak, P.; Bezshapkin, V.; Gligorijevic, V.; Bonneau, R.; Kosciolek, T.; Vatanen, T.
10.1101/2022.06.06.494653 — bioinformatics — Posted on 2022-06-06
3271 On the prediction of arginine glycation using artificial neural networks
Que-Salinas, U.; Martinez-Peon, D.; Reyes-Figueroa, A. D.; Ibarra, I.; Scheckhuber, C. Q.
10.1101/2022.06.05.494871 — biochemistry — Posted on 2022-06-06
3274 Ts66Yah, a refined Ts65Dn DS mouse model, unravels genetic interaction between regions homologous to Human chromosome 21 and the Scaf8-Pde10a genetic interval.
Duchon, A.; Muniz Moreno, M. d. M.; Chevalier, C.; Nalesso, V.; Andre, P.; Fructuoso-Castellar, M.; Mondino, M.; Po, C.; Noblet, V.; Birling, M.-C.; Potier, M.-C.; Herault, Y.
10.1101/2022.06.06.494940 — genetics — Posted on 2022-06-06
3276 Projecting the futures of plant traits across habitats in Central Europe
Golivets, M.; Knapp, S.; Essl, F.; Lenzner, B.; Latombe, G.; Leung, B.; Kuehn, I.
10.1101/2022.06.06.494936 — ecology — Posted on 2022-06-06
3277 Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype
Tagoe, H.; Hassan, S.; Youssef, G.; Mills, K.; Harper, J.; O'Shaughnessy, R. F.
10.1101/2022.06.06.494922 — cell biology — Posted on 2022-06-06
3280 Is the production of reactive oxygen and nitrogen species by macrophages associated with better infectious control in the experimental disseminated and pulmonary mucormycosis?
Santos, A. R. d.; Fraga-Silva, T. F.; Donanzam, D. d. F. A.; Finatto, A. C.; Marchetti, C.; Andrade, M. I.; Arruda, O. S. d.; Arruda, M. S. P. d.; Venturini, J.
10.1101/2022.06.06.494943 — immunology — Posted on 2022-06-06
3281 Contrasting autoimmune and treatment effects reveals baseline set points of immune toxicity following checkpoint inhibitor treatment
Zhao, C.; Mule, M. P.; Martins, A. J.; Pinal-Fernandez, I.; Donahue, R. N.; Chen, J.; Schlom, J.; Gulley, J. L.; Mammen, A.; Tsang, J. S.; Rajan, A.
10.1101/2022.06.05.494592 — immunology — Posted on 2022-06-06
3282 Cortical synapses of the world's smallest mammal: an FIB/SEM study in the Etruscan shrew
Alonso-Nanclares, L.; Rodriguez, J. R.; Merchan-Perez, A.; Gonzalez-Soriano, J.; Plaza-Alonso, S.; Cano-Astorga, N.; Naumann, R. K.; Brecht, M.; DeFelipe, J.
10.1101/2022.06.06.494946 — neuroscience — Posted on 2022-06-06
3286 Induction of senescence renders cancer cells highly immunogenic
Marin, I.; Boix, O.; Garcia-Garijo, A.; Sirois, i.; Caballe, A.; Zarzuela, E.; Ruano, I.; Stephan-Otto Attolini, C.; Prats, N.; Lopez-Dominguez, J. A.; Kovatcheva, M.; Garralda, E.; Munoz, J.; Caron, E.; Abad, M.; Gros, A.; Pietrocola, F.; Serrano, M.
10.1101/2022.06.05.494912 — cancer biology — Posted on 2022-06-06
3288 Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
Borsatto, A.; Akkad, O.; Galdadas, I.; Ma, S.; Damfo, S.; Haider, S.; Kozielski, F.; Estarellas, C.; Gervasio, F. L.
10.1101/2022.05.20.492819 — biophysics — Posted on 2022-06-06
3289 ImputeCoVNet: 2D ResNet Autoencoder for Imputation of SARS-CoV-2 Sequences
Pesaranghader, A.; Pelletier, J.; Grenier, J.-C.; Poujol, R.; Hussin, J.
10.1101/2021.08.13.456305 — bioinformatics — Posted on 2022-06-06
3293 Neutrophil-epithelial interactions augment infectivity and pro-inflammatory responses to SARS-CoV-2 infection
Calvert, B. A.; Quiroz, E. J.; Lorenzana, Z.; Doan, N.; Kim, S.; Senger, C. N.; Wallace, W. D.; Salomon, M.; Henley, J.; Ryan, A. L.
10.1101/2021.08.09.455472 — cell biology — Posted on 2022-06-06
3294 Preclinical efficacy, safety, and immunogenicity of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2
Barreiro, A.; Prenafeta, A.; Bech-Sabat, G.; Roca, M.; Perozo, E.; March, R.; Gonzalez, L.; Madrenas, L.; Corominas, J.; Fernandez, A.; Moros, A.; Molas, M.; Pentinat, T.; Panosa, C.; Moreno, A.; Puigvert, E.; Pol, E.; Palmada, J.; Garriga, C.; Prat, T.; Vergara-Alert, J.; Lorca-Oro, C.; Roca, N.; Fernandez-Bastit, L.; Rodon, J.; Perez, M.; Segales, J.; Pradenas, E.; Marfil, S.; Trinite, B.; Ortiz, R.; Clotet, B.; Blanco, J.; Diaz Pedroza, J.; Ampudia Carrasco, R.; Rosales Salgado, Y.; Loubat Casanovas, J.; Capdevila Larripa, S.; Garcia Prado, J.; Barretina Ginesta, J.; Sistere-Oro, M.; Ceboll
10.1101/2021.11.22.469117 — immunology — Posted on 2022-06-06
3298 Developmental cell fate choice employs two distinct cis regulatory strategies
Delas, M. J.; Kalaitzis, C. M.; Fawzi, T.; Demuth, M.; Zhang, I.; Stuart, H. T.; Costantini, E.; Ivanovitch, K.; Tanaka, E.; Briscoe, J.
10.1101/2022.06.06.494792 — developmental biology — Posted on 2022-06-06
3299 GM1 asymmetry in the membrane stabilizes pores
Aleksanyan, M.; Lira, R. B.; Steinkuehler, J.; Dimova, R.
10.1101/2022.01.21.477228 — biophysics — Posted on 2022-06-06
3301 Sex differences in allometry for mouse phenotypic traits indicate that females are not scaled males
Wilson, L. A. B.; Zajitschek, S. R. K.; Lagisz, M.; Mason, J.; Haselimashhadi, H.; Nakagawa, S.
10.1101/2022.03.29.486193 — evolutionary biology — Posted on 2022-06-06
3303 Mathematically and biologically consistent framework for presence-absence pairwise indices
Sizling, A. L.; Keil, P.; Tjorve, E.; Tjorve, K. M. C.; Zarsky, J. D.; Storch, D.
10.1101/2021.07.14.452244 — ecology — Posted on 2022-06-06
3308 Homeostatic control of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from Mycobacterium smegmatis
Gautam, S.; Mahapa, A.; Yeramala, L.; Gandhi, A.; Krishnan, S.; Kutti, V. R.; Chatterji, D.
10.1101/2021.11.20.466133 — biophysics — Posted on 2022-06-06
3313 bHLH heterodimer complex variations shape meristems in Arabidopsis thaliana by affecting target gene specificity
De Rybel, B.; Mor, E.; Pernisova, M.; Minne, M.; Cerutti, G.; Ripper, D.; Nolf, J.; Andres, J.; Ragni, L.; Zurbriggen, M. D.; Vernoux, T.
10.1101/2022.06.02.494582 — developmental biology — Posted on 2022-06-05
3314 Rab11-FIP1C is dispensable for HIV-1 replication in primary CD4+ T cells but its role is cell-type-dependent in immortalized human T-cell lines
Freed, E. O.; de Cespedes, M. V.; Hoffman, H. K.; Carter, H.; Simons, L. M.; Naing, L.; Ablan, S. D.; Hultquist, J. F.; van Engelenburg, S. B.
10.1101/2022.06.03.494784 — microbiology — Posted on 2022-06-05
3316 Protein profiling of breast carcinomas reveals expression of immune-suppressive factors and signatures relevant to patient outcome
Ruoff, F.; Kersten, N.; Anderle, N.; Jerbi, S.; Stahl, A.; Koch, A.; Staebler, A.; Hartkopf, A.; Brucker, S. Y.; Hahn, M.; Schenke-Layland, K.; Schmees, C.; Templin, M.
10.1101/2022.06.03.494654 — cancer biology — Posted on 2022-06-05
3318 DeepTracer ID: De Novo Protein Identification from Cryo-EM Maps
Chang, L.; Wang, F.; Connolly, K.; Meng, H.; Su, Z.; Cvirkaite-Krupovic, V.; Krupovic, M.; Egelman, E. H.; Si, D.
10.1101/2022.06.03.494766 — biophysics — Posted on 2022-06-05
3319 Tubule jamming in the developing kidney creates cyclical mechanical stresses instructive to nephron formation
Viola, J. M.; Liu, J.; Prahl, L. S.; Huang, A.; Chan, T. J.; Hayward-Lara, G.; Porter, C. M.; Hughes, A. J.
10.1101/2022.06.03.494718 — bioengineering — Posted on 2022-06-05
3320 ECM-derived biophysical cues mediate interstitial flow-induced sprouting angiogenesis
Chang, C.-W.; Shih, H.-C.; Cortes-Medina, M.; Beshay, P. E.; Avendano, A.; Seibel, A. J.; Liao, W.-H.; Tung, Y.-C.; Song, J. W.
10.1101/2022.06.04.494804 — bioengineering — Posted on 2022-06-05
3322 PRC2 clock: a universal biomarker of aging and rejuvenation
Moqri, M.; Cipriano, A.; Nachun, D.; Murty, T.; de Sena Brandine, G.; Rasouli, S.; Tarkhov, A.; Aberg, K. A.; van den Oord, E. J.; Zhou, W.; Smith, A. D.; Mackall, C.; Gladyshev, V. N.; Horvath, S.; Snyder, M.; Sebastiano, V.
10.1101/2022.06.03.494609 — genomics — Posted on 2022-06-05
3324 Regulation of Klebsiella pneumoniae mucoidy by the bacterial tyrosine kinase Wzc
Khadka, S.; Ring, B.; Krzeminski, L. R.; Hathaway, M.; Walker, R. S.; Mobley, H.; Mike, L. A.
10.1101/2022.06.05.494587 — microbiology — Posted on 2022-06-05
3326 Role of Calcitonin Gene-Related Peptide (CGRP) in Auditory, Static, and Dynamic Imbalance Behaviors: Implications for Vestibular Migraine
Rahman, S. M.; Hauser, C.; Faucher, S.; Fine, E.; Jonnala, R.; Duzgezen, V.; Strangio, B.; Liang, B.; Luebke, A. E.
10.1101/2022.06.03.494764 — neuroscience — Posted on 2022-06-05
3327 Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex
Cadeddu, R.; Mosher, L. J.; Nordkild, P.; Gaikwad, N. G.; Ratto, G. M.; Scheggi, S.; Bortolato, M.
10.1101/2022.06.05.494755 — neuroscience — Posted on 2022-06-05
3329 A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.
Tuddenham, J. F.; Taga, M.; Haage, V.; Roostaei, T.; White, C.; Lee, A. J.; Fujita, M.; Khairallah, A.; Green, G.; Hyman, B.; Frosch, M.; Hopp, S.; Beach, T. G.; Corboy, J.; Habib, N.; Klein, H.-U.; Soni, R. K.; Teich, A. F.; Hickman, R. A.; Alcalay, R. N.; Shneider, N.; Schneider, J.; Sims, P. A.; Bennet, D. A.; Olah, M.; Menon, V.; De Jager, P. L.
10.1101/2022.06.04.494709 — neuroscience — Posted on 2022-06-05
3331 Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Mattis, K. K.; Krentz, N. A. J.; Metzendorf, C.; Abaitua, F.; Spigelman, A. F.; Sun, H.; Rottner, A. K.; Bautista, A.; Mazzaferro, E.; Perez-Alcantara, M.; Manning Fox, J. E.; Torres, J. M.; Weslowska-Andersen, A.; Yu, G. Z.; Mahajan, A.; Larsson, A.; MacDonald, P. E.; Davies, B.; den Hoed, M.; Gloyn, A. L.
10.1101/2022.06.04.494826 — physiology — Posted on 2022-06-05
3333 Fanca and p53 genes cooperate to suppress oral SCC in transgenic mice
Errazquin, R.; Page, A.; Sunol, A.; Segrelles, C.; Carrasco, E.; Peral, J.; Garrido, A.; Del Marro, S.; Ortiz, J.; Lorz, C.; Minguillon, J.; Surralles, J.; Belendez, C.; Alvarez, M.; Balmana, J.; Bravo, A.; Ramirez, A.; Garcia-Escudero, R.
10.1101/2022.06.05.494848 — cancer biology — Posted on 2022-06-05
3334 Senescence rewires microenvironment sensing to facilitate anti-tumor immunity
Chen, H.-A.; Ho, Y.-J.; Mezzadra, R.; Adrover, J. M.; Smolkin, R. M.; Zhu, C.; Wei, L.; Wuest, A.; Tian, S.; Li, X.; Hendrickson, R. C.; Egeblad, M.; Alonso-Curbelo, D.; Lowe, S. W.
10.1101/2022.06.04.494739 — cancer biology — Posted on 2022-06-05
3336 Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties
Ragaller, F.; Andronico, L.; Sykora, J.; Kulig, W.; Rog, T.; Urem, Y. B.; Amaro, M.; Abhinav, A.; Danylchuk, D. I.; Klymchenko, A. S.; Hof, M.; Vattulainen, I.; Sezgin, E.
10.1101/2022.06.05.494874 — biophysics — Posted on 2022-06-05
3337 Processing UMI Datasets at High Accuracy and Efficiency with the Sentieon ctDNA Analysis Pipeline
Hu, J.; Jiang, C.; Huang, Y. S.; Chen, H.; Feng, H.; Freed, D.; Qu, Y.; Fan, R.; Su, Z.; Chen, W.
10.1101/2022.06.03.494742 — bioinformatics — Posted on 2022-06-05
3338 Bayesian Optimization for Ternary Complex Prediction (BOTCP)
Rao, A.; Tunjic, T. M.; Brunsteiner, M.; Mueller, M.; Fooladi, H.; Weber, N.
10.1101/2022.06.03.494737 — bioinformatics — Posted on 2022-06-05
3340 Development and application of an uncapped mRNA platform
Liu, B.; Ni, P.; Cai, L.; Shi, X.; Ji, S.; Ke, Z.; Zhang, S.; Hu, B.; Yang, B.; Xu, Y.; Long, W.; Fang, Z.; Hu, H.; Wang, Y.; Zhang, W.; Geng, H.; Xu, Y.; Zheng, X.; Wang, Z.; Zhang, B.; Pan, K.; Zhou, K.; Cui, Y.; Wang, H.; Liu, B.
10.1101/2022.06.05.494796 — bioengineering — Posted on 2022-06-05
3343 Ancient DNA evidence for the ecological globalisation of cod fishing in medieval and post-medieval Europe
Garcia, L. M.; Ferrari, G.; Cuevas, A.; Atmore, L. M.; Lopez-Arias, B.; Culling, M.; Llorente-Rodriguez, L.; Morales-Muniz, A.; Rosello-Izquierdo, E.; Quiros, J. A.; Marlasca-Martin, R.; Hanfling, B.; Hutchinson, W. F.; Jakobsen, K. S.; Jentoft, S.; Orton, D.; Star, B.; Barrett, J. H.
10.1101/2022.06.03.494519 — ecology — Posted on 2022-06-05
3348 Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions
Fan, J.; Ren, J.; He, R.; Wei, P.; Li, Y.; Li, W.; Chen, D.; Druzhinina, I.; Li, Z.; Yin, W.
10.1101/2022.06.05.494846 — microbiology — Posted on 2022-06-05
3349 Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers
Barman, S.; Borriello, F.; Brook, B.; Pietrasanta, C.; De Leon, M.; Sweitzer, C.; Menon, M.; D. van Haren, S.; Soni, D.; Saito, Y.; Nanishi, E.; Yi, S.; Bobbala, S.; Levy, O.; Scott, E. A.; Dowling, D. J.
10.1101/2022.06.03.494753 — immunology — Posted on 2022-06-05
3354 Simultaneously cholinergic projection in Ascending and Descending Circuits from Midbrain
Zhao, P.; Jiang, T.; Wang, H.; Jia, X.; Li, A.; Yuan, J.; Luo, Q.; Li, X.; Gong, H.
10.1101/2022.06.05.494860 — neuroscience — Posted on 2022-06-05
3358 Proteomic Dynamics of Breast Cancers Identifies Potential Therapeutic Protein Targets
Sun, R.; Zhu, Y. J.; Savad, A.; Ge, W.; Luna, A.; Liang, S.; Segura, L. T.; Rajapakse, V. N.; Yu, C.; Zhang, H.; Fang, J.; Wu, F.; Xie, H.; Saez-Rodriguez, J.; Ying, H.; Reinhold, W. C.; Sander, C.; Pommier, Y.; Neel, B. G.; Guo, T.; Aebersold, R.
10.1101/2022.06.03.494776 — systems biology — Posted on 2022-06-05
3359 Distributed information encoding and decoding using self-organized spatial patterns
Lu, J.; Tsoi, R.; Luo, N.; Ha, Y.; Wang, S.; Kwak, M.; Baig, Y.; Moiseyev, N.; Tian, S.; Zhang, A.; Gong, N. Z.; You, L.
10.1101/2022.06.04.494770 — systems biology — Posted on 2022-06-05
3360 Arabidopsis MLO4 Functions as a Ca2+ Channel Essential for Mechanosensing in Root Tips
Zhang, Z.; Sun, Y.; Lu, P.; Feng, C.; Niu, Q.; Lin, G.; Kong, D.; Liu, L.; Luan, S.; Li, L.; HOU, C.
10.1101/2022.06.05.494847 — plant biology — Posted on 2022-06-05
3362 A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes
Radtke, A. J.; Postovalova, E.; Varlamova, A.; Bagaev, A.; Sorokina, M.; Kudryashova, O.; Meerson, M.; Polyakova, M.; Galkin, I.; Svekolkin, V.; Isaev, S.; Perelman, G.; Lozinsky, Y.; Yaniv, Z.; Lowekamp, B. C.; Speranza, E.; Yao, L.; Pittaluga, S.; Shaffer, A. L.; Jonigk, D.; Phelan, J.; Davies-Hill, T.; Huang, D. w.; Ovcharov, P.; Nomie, K.; Nuzhdina, E.; Kotlov, N.; Ataullakhanov, R.; Fowler, N.; Kelly, M. C.; Muppidi, J.; Davis, J. L.; Hernandez, J. M.; Wilson, W. H.; Jaffe, E. S.; Staudt, L. M.; Roschewski, M.; Germain, R. N.
10.1101/2022.06.03.494716 — cancer biology — Posted on 2022-06-05
3363 Illumination of a progressive allosteric mechanism mediating the glycine receptor activation
Shi, S.; Lefebvre, S. N.; Peverini, L.; Cerdan, A. H.; Gielen, M.; Changeux, J.-P.; CECCHINI, M.; Corringer, P.-J.
10.1101/2022.06.04.494798 — biophysics — Posted on 2022-06-05
3365 GPU-Accelerated All-atom Particle-Mesh Ewald Continuous Constant pH Molecular Dynamics in Amber
Harris, J. A.; Liu, R.; Martins de Oliveira, V.; Vazquez Montelongo, E.; Henderson, J. A.; Shen, J.
10.1101/2022.06.04.494833 — biophysics — Posted on 2022-06-05
3369 7-UP: generating in silico CODEX from a small set of immunofluorescence markers
Wu, E.; Trevino, A. E.; Wu, Z.; Swanson, K.; Kim, H. J.; D'Angio, H. B.; Preska, R.; Charville, G. W.; Dalerba, P. D.; Duvvuri, U.; Levi, J.; Colevas, A. D.; Bedi, N.; Chang, S.; Sunwoo, J. B.; Mayer, A. T.; Zou, J.
10.1101/2022.06.03.494624 — bioinformatics — Posted on 2022-06-05
3370 Community assessment of methods to deconvolve cellular composition from bulk gene expression
White, B. S.; de Reynies, A.; Newman, A. M.; Waterfall, J. J.; Lamb, A.; Petitprez, F.; Yu, T.; Guo, X.; Valdeolivas, A.; Lin, Y.; Li, H.; Xiao, X.; Wang, S.; Zheng, F.; Yang, W.; Yu, R.; Guerrero-Gimenez, M. E.; Catania, C. A.; Lang, B. J.; Domanskyi, S.; Bertus, T. J.; Piermarocchi, C.; Monaco, G.; Caruso, F. P.; Ceccarelli, M.; Coller, J.; Maecker, H.; Duault, C.; Sokoohi, V.; Patel, S.; Liliental, J. E.; Simon, S.; Tumor Deconvolution DREAM Challenge consortium, ; Saez-Rodriguez, J.; Heiser, L. M.; Guinney, J.; Gentles, A. J.
10.1101/2022.06.03.494221 — bioinformatics — Posted on 2022-06-05
3371 Super-resolution stimulated Raman Scattering microscopy with A-PoD
Jang, H.; Li, Y.; Fung, A.; Bagheri, P.; Hoang, K.; Skowronska-Krawczyk, D.; Chen, X.; Wu, J. Y.; Bintu, B.; Shi, L.
10.1101/2022.06.04.494813 — bioengineering — Posted on 2022-06-05
3372 CryoEM Structures of the Nitrogenase Complex During Catalytic Turnover
Rutledge, H. L.; Cook, B. D.; Nguyen, H. P. M.; Herzik, M. A.; Tezcan, F. A.
10.1101/2022.06.05.494884 — biochemistry — Posted on 2022-06-05
3374 Epigenome-wide association study analysis of calorie restriction in humans, CALERIE™ Trial analysis
Ramaker, M. E.; Corcoran, D. L.; Apsley, A. T.; Kraus, V. B.; Kraus, W. E.; Kobor, M. S.; Lin, D. T.; Orenduff, M. C.; Waziry, R.; Huffman, K. M.; Belsky, D. W.
10.1101/2022.06.03.494722 — genomics — Posted on 2022-06-05
3375 Polygenic Transcriptome Risk Scores Can Translate Genetic Results Between Species
Santhanam, N.; Sanchez-Roige, S.; Liang, Y.; Chitre, A.; Munro, D.; Chen, D.; Cheng, R.; Gao, J.; George, A. M.; Gileta, A.; Holl, K.; Hughson, A.; King, C. P.; Lamparelli, A. C.; Martin, C. D.; Martinez, A. G.; Mi, S.; St. Pierre, C. L.; Tripi, J.; Wang, T.; Chen, H.; Flagel, S.; Ishiwari, K.; Meyer, P.; Saba, L.; Woods, L. S.; Polesskaya, O.; Palmer, A. A.; Im, H. K.
10.1101/2022.06.03.494719 — genomics — Posted on 2022-06-05
3378 Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during Aging
Wu, Y.; Zhu, B.; Zhang, R.; Goplen, N. P.; Gao, X.; Narasimhan, H.; Shi, A.; Chen, Y.; Li, Y.; Dong, H.; Braciale, T. J.; Sun, J.
10.1101/2022.06.04.494822 — immunology — Posted on 2022-06-05
3381 QuNex -- An Integrative Platform forReproducible Neuroimaging Analytics
Ji, J. L.; Demsar, J.; Fonteneau, C.; Tamayo, Z.; Pan, L.; Kraljic, A.; Matkovic, A.; Purg, N.; Helmer, M.; Warrington, S.; Sotiropoulos, S.; Harms, M.; Murray, J. D.; Anticevic, A.; Repovs, G.
10.1101/2022.06.03.494750 — neuroscience — Posted on 2022-06-05
3382 Bumetanide increases microglia-interneuron contact following traumatic brain injury
Tessier, M.; Garcia, M. S.; Goubert, E.; Tian, L.; Molinari, F.; Blasco, E.; Laurin, J.; Guillemot, F.; Hubner, C.; Pellegrino, c. A.; Rivera, C.
10.1101/2022.06.03.494659 — neuroscience — Posted on 2022-06-05
3383 Population geometry enables fast sampling in spiking neural networks
Masset, P.; Zavatone-Veth, J. A.; Connor, J. P.; Murthy, V. N.; Pehlevan, C.
10.1101/2022.06.03.494680 — neuroscience — Posted on 2022-06-05
3385 Increasing information gain in animal research by improving statistical model accuracy
Waterkamp, C.; von Kortzfleisch, V. T.; Neu, C.; Kitanovski, S.; Richter, S. H.; Hoffmann, D.
10.1101/2022.06.03.494726 — bioinformatics — Posted on 2022-06-05
3387 Multi-task learning for single-cell multi-modality biology
Tang, X.; Zhang, J.; He, Y.; Zhang, X.; Lin, Z.; Partarrieu, S.; Bou Hanna, E.; Ren, Z.; Yang, Y.; Wang, X.; Li, N.; Ding, J.; Liu, J.
10.1101/2022.06.03.494730 — genomics — Posted on 2022-06-05
3390 Exceptional fossil preservation and evolution of the ray-finned fish brain
Figueroa, R. T.; Goodvin, D.; Kolmann, M.; Coates, M. I.; Caron, A. M.; Friedman, M.; Giles, S.
10.1101/2022.06.04.492470 — paleontology — Posted on 2022-06-05
3391 HIRA loss transforms FH-deficient cells
Valcarcel-Jimenez, L.; Rogerson, C.; Yong, C.; Schmidt, C.; Yang, M.; Harle, V.; Offord, V.; Wong, K.; Mora, A. N.; Speed, A.; Caraffini, V.; Tran, M. G. B.; Maher, E. R.; Stewart, G. D.; Vanharanta, S.; Adams, D.; Frezza, C.
10.1101/2022.06.04.492123 — cancer biology — Posted on 2022-06-05
3392 Membrane wetting, molding and reticulation by protein condensates
Mangiarotti, A.; Chen, N.; Zhao, Z.; Lipowsky, R.; Dimova, R.
10.1101/2022.06.03.494704 — biophysics — Posted on 2022-06-05
3393 Autoregulation of a trimeric transporter involves the cytoplasmic domains of both adjacent subunits
Leone, V.; Bradshaw, R. T.; Koshy, C.; Lee, P. S.; Fenollar-Ferrer, C.; Heinz, V.; Ziegler, C.; Forrest, L. R.
10.1101/2022.06.05.494857 — biochemistry — Posted on 2022-06-05
3395 EP300 (p300) mediated histone butyrylation is critical for adipogenesis
Kundu, T. K.; Bhattacharya, A.; Chatteerjee, S.; Bhaduri, U.; Singh, A. K.; Vasudevan, M.; Sashidhara, K. V.; Guha, R.; Natesh, N.; Nazir, A.; Rath, S. K.
10.1101/2021.08.01.454641 — molecular biology — Posted on 2022-06-05
3396 Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales
Morgan, A. P.; Hughes, J. J.; Didion, J. P.; Jolley, W. J.; Campbell, K. J.; Threadgill, D. W.; Bonhomme, F.; Searle, J. B.; Pardo Manuel de Villena, F.
10.1101/2022.02.17.478179 — genetics — Posted on 2022-06-05
3397 A giant virus genome is densely packaged by stable nucleosomes within virions
Bryson, T. D.; De Ioannes, P.; Valencia-Sanchez, M. I.; Henikoff, J. G.; Talbert, P. B.; La Scola, B.; Armache, K.-J.; Henikoff, S.
10.1101/2022.01.15.476465 — evolutionary biology — Posted on 2022-06-05
3399 Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents
Sommerfeld, L. C.; Holmes, A. P.; Yu, T. Y.; O'Shea, C.; Kavanagh, D. M.; Pike, J. A.; Wright, T.; Syeda, F.; Aljehani, A.; Kew, T.; Cardoso, V. R.; Kabir, S. N.; Hepburn, C.; Menon, P. M.; Broadway-Stringer, S.; O'Reilly, M.; Witten, A.; Fortmueller, L.; Lutz, S.; Kulle, A.; Gkoutos, G. V.; Pavlovic, D.; Arlt, W.; Lavery, G. G.; Steeds, R.; Gehmlich, K.; Stoll, M.; Kirchhof, P.; Fabritz, L.
10.1101/2022.06.03.494748 — molecular biology — Posted on 2022-06-05
3400 CD39 Identifies Tumor-Reactive CD8 T cells in Patients With Lung Cancer
Chow, A.; Uddin, F. Z.; Mangarin, L.; Rizvi, H.; Dobrin, A.; Tischfield, S. E.; Quintanal-Villalonga, A.; Chan, J. M.; Shah, N. S.; Allaj, V.; Manoj, P.; Mattar, M.; Meneses, M.; Liu, M.; Landau, R.; Ward, M.; Kulick, A.; Kwong, C.; Wierzbicki, M.; Yavner, J.; Chavan, S.; Farillas, A.; Holland, A.; Sridhar, H.; Ciampricotti, M.; Hirschhorn-Cymerman, D.; Richards, A.; Donoghue, M. T. A.; Heller, G.; Klebanoff, C. A.; Hellmann, M. D.; de Stanchina, E.; Sen, T.; Wolchok, J. D.; Merghoub, T.; Rudin, C. M.
10.1101/2022.01.24.477554 — immunology — Posted on 2022-06-05
3407 Clonal inactivation of telomerase promotes accelerated stem cell differentiation
Hasegawa, K.; Zhao, Y.; Garbuzov, A.; Corces, R. M.; Chen, L.; Cheung, P.; Wei, Y.; Chang, H. Y.; Artandi, S. E.
10.1101/2021.04.28.441728 — developmental biology — Posted on 2022-06-05
3408 A small DNA virus initiates replication with no more than three genome copies per cell
Ren, R.; Zheng, L.; Perdoncini Carvalho, C.; Han, J.; Miyashita, S.; Zhang, D.; Qu, F.
10.1101/2022.05.27.493787 — microbiology — Posted on 2022-06-05
3410 Simultaneous classification of neuroactive compounds in zebrafish
Myers-Turnbull, D.; Taylor, J. C.; Helsell, C.; Tummino, T. A.; Mccarroll, M. N.; Alexander, R.; Ki, C. S.; Gendelev, L.; Kokel, D.
10.1101/2020.01.01.891432 — systems biology — Posted on 2022-06-05
3412 Tactile attention modulates occipital alpha oscillations in early blindness
Gurtubay-Antolin, A.; Bruna, R.; Collignon, O.; Rodriguez-Fornells, A.
10.1101/2022.06.03.494660 — neuroscience — Posted on 2022-06-05
3414 Cyclin B3 implements timely vertebrate oocyte arrest for fertilization
Bouftas, N.; Schneider, L.; Halder, M.; Demmig, R.; Baack, M.; Cladiere, D.; Walter, M.; Al Abdallah, H.; Kleinhempel, C.; Mueller, J.; Passarelli, F.; Wehrle, P.; Heim, A.; Wassmann, K.; Mayer, T. U.
10.1101/2022.06.04.494806 — cell biology — Posted on 2022-06-04
3415 AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro
Sieckmann, K.; Winnerling, N.; Huebecker, M.; Leyendecker, P.; Ribeiro, D.; Gnad, T.; Pfeifer, A.; Wachten, D.; Hansen, J. N.
10.1101/2022.06.04.494793 — cell biology — Posted on 2022-06-04
3416 Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss
Larouche, J. A.; Wallace, E. C.; Spence, B. D.; Johnson, S. A.; Kulkarni, M.; Buras, E.; Brown, B. N.; Badylak, S. F.; Aguilar, C. A.
10.1101/2022.06.03.494707 — cell biology — Posted on 2022-06-04
3418 UNC-45 has a crucial role in maintaining muscle sarcomeres during aging in C. elegans
Matheny, C. J.; Qadota, H.; Kimelman, M.; Bailey, A. O.; Oberhauser, A. F.; Benian, G.
10.1101/2022.06.04.494828 — cell biology — Posted on 2022-06-04
3419 All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals
Bergs, A. C.; Liewald, J. F.; Rodriguez-Rozada, S.; Liu, Q.; Wirt, C.; Bessel, A.; Zeitzschel, N.; Durmaz, H.; Nozownik, A.; Vierock, J.; Bargmann, C.; Hegemann, P.; Wiegert, J. S.; Gottschalk, A.
10.1101/2022.06.03.494532 — neuroscience — Posted on 2022-06-04
3420 NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density
Somasundaram, V.; Ridnour, L. A.; Cheng, R. Y. S.; Walke, A. J.; Kedei, N.; Bhattacharyya, D. D.; Wink, A. L.; Edmondson, E. F.; Butcher, D.; Warner, A.; Dorsey, T. H.; Scheiblin, D. A.; Heinz, W.; Bryant, R. J.; Kinders, R.; Lipkowitz, S.; Wong, S. T.; Pore, M.; Hewitt, S. M.; McVicar, D. W.; Anderson, S. K.; Chang, J.; Glynn, S. A.; Ambs, S.; Lockett, S. J.; Wink, D. A.
10.1101/2022.06.03.494733 — cancer biology — Posted on 2022-06-04
3423 Multi-omics analysis identifies drivers of protein phosphorylation
Zhang, T.; Keele, G. R.; Gerdes Gyuricza, I.; Vincent, M.; Brunton, C.; Bell, T. A.; Hock, P.; Shaw, G. D.; Munger, S. C.; Pardo-Manuel de Villena, F.; Ferris, M. T.; Paulo, J. A.; Gygi, S. P.; Churchill, G. A.
10.1101/2022.06.03.494740 — genomics — Posted on 2022-06-04
3424 ASAR RNAs control replication through interactions with dozens of RNA binding proteins
Thayer, M. J.; Heskett, M. B.; Smith, L. G.; Spellman, P. T.; Yates, P. A.
10.1101/2022.06.04.494840 — genetics — Posted on 2022-06-04
3428 Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents
Sommerfeld, L. C.; Holmes, A. P.; Yu, T. Y.; O'Shea, C.; Kavanagh, D. M.; Pike, J. A.; Wright, T.; Syeda, F.; Aljehani, A.; Kew, T.; Cardoso, V. R.; Kabir, S. N.; Hepburn, C.; Menon, P. M.; Broadway-Stringer, S.; O'Reilly, M.; Witten, A.; Fortmueller, L.; Lutz, S.; Kulle, A.; Pavlovic, D.; Arlt, W.; Lavery, G. G.; Steeds, R.; Gehmlich, K.; Stoll, M.; Kirchhof, P.; Fabritz, L.
10.1101/2022.06.03.494748 — molecular biology — Posted on 2022-06-04
3429 Modeling cellular co-infection and reassortment of bluetongue virus in Culicoides midges
Cavany, S. M.; Barbera, C.; Carpenter, M.; Rodgers, C.; Stenglein, M. D. M.; Mayo, C.; Perkins, A.
10.1101/2022.06.03.494504 — microbiology — Posted on 2022-06-04
3430 Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease
Hu, S.; Bourgonje, A. R.; Gacesa, R.; Jansen, B. H.; Björk, J. R.; Bangma, A.; Hidding, I. J.; van Dullemen, H. M.; Visschedijk, M. C.; Faber, K. N.; Dijkstra, G.; Harmsen, H. J. M.; Festen, E. A. M.; Vich Vila, A.; Spekhorst, L. M.; Weersma, R. K.
10.1101/2022.06.04.494807 — microbiology — Posted on 2022-06-04
3431 Molecular epidemiology of carbapenemase-producing Acinetobacter spp. from Israel, 2001-2006: earliest report of blaNDM predating the oldest known blaNDM-positive strains
Grenier, F.; Baby, V.; Allard, S.; Heynemand, F.; Levesque, S.; Sullivan, R.; Landecker, H. L.; Higgins, P. G.; Rodrigue, S.; Haraoui, L.-P.
10.1101/2022.06.03.494778 — microbiology — Posted on 2022-06-04
3433 Single-cell imaging reveals non-cooperative and cooperative infection strategies of Listeria monocytogenes in macrophages
Moran, J.; Feltham, L.; Bagnall, J.; Goldrick, M. C.; Lord, E. A.; Nettleton, C.; Spiller, D. G.; Roberts, I.; Paszek, P.
10.1101/2022.06.04.493993 — microbiology — Posted on 2022-06-04
3435 Role of Calcitonin Gene-Related Peptide (CGRP) in Auditory, Static, and Dynamic Imbalance Behaviors: Implications for Vestibular Migraine
Rahman, S. M.; Hauser, C.; Faucher, S.; Fine, E.; Jonnala, j.; Duzgezen, V.; Stangio, B.; Liang, B.; Luebke, A. E.
10.1101/2022.06.03.494764 — neuroscience — Posted on 2022-06-04
3439 RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections
Lace, B.; Su, C.; Invernot Perez, D.; Rodriguez-Franco, M.; Vernie, T.; Batzenschlager, M.; Egli, S.; Liu, C.-W.; Ott, T.
10.1101/2022.06.03.494689 — plant biology — Posted on 2022-06-04
3441 Robust deep learning based protein sequence design using ProteinMPNN
Dauparas, J.; Anishchenko, I.; Bennett, N.; Bai, H.; Ragotte, R. J.; Milles, L. F.; Wicky, B. I. M.; Courbet, A.; de Haas, R. J.; Bethel, N.; Leung, P. J. Y.; Huddy, T. F.; Pellock, S.; Tischer, D.; Chan, F.; Koepnick, B.; Nguyen, H.; Kang, A.; Sankaran, B.; Bera, A.; King, N. P.; Baker, D.
10.1101/2022.06.03.494563 — biophysics — Posted on 2022-06-04
3445 Protein nanobarcodes enable single-step multiplexed fluorescence imaging
de Jong-Bolm, D.; Sadeghi, M.; Bao, G.; Klaehn, G.; Hoff, M.; Mittelmeier, L.; Basmanav, F. B.; Opazo, F.; Noe, F.; Rizzoli, S. O.
10.1101/2022.06.03.494744 — cell biology — Posted on 2022-06-04
3448 Screening the PRISM library against Staphylococcus aureus reveals a sesquiterpene lactone from Liriodendron tulipifera with inhibitory activity
Kirk, R. D.; Rosario, M. E.; Oblie, N.; Jouaneh, T. M. M.; Carro, M. A.; Wu, C.; Leibovitz, E.; Hunter, E. S.; Literman, R.; Handy, S. M.; Rowley, D. C.; Bertin, M. J.
10.1101/2022.06.03.494747 — microbiology — Posted on 2022-06-04
3450 Topical Delivery of Elastic Liposomal Vesicles for Treatment of Middle and Inner Ear Disease
Sadabad, R. K.; Xia, A.; Benkafadar, N.; Faniku, C.; Piado, D.; Yang, S.; Valdez, T.
10.1101/2022.06.02.494551 — bioengineering — Posted on 2022-06-04
3452 Characterization of non-human primate dura in health and neurodegeneration
Romanova, L.; Janson, C.; Muller, S.; Hauser, K.; Lam, C.; Hansen, E.
10.1101/2022.06.03.477517 — neuroscience — Posted on 2022-06-04
3456 Inter-layer and inter-subject variability of circadian gene expression in human skin
del Olmo, M.; Spoerl, F.; Korge, S.; Juerchott, K.; Felten, M.; Grudziecki, A.; de Zeeuw, J.; Nowozin, C.; Reuter, H.; Blatt, T.; Herzel, H.; Kunz, D.; Kramer, A.; Ananthasubramaniam, B.
10.1101/2022.06.03.494693 — bioinformatics — Posted on 2022-06-04
3459 Laser particle barcoding for multi-pass high-dimensional flow cytometry
Kwok, S. J.; Forward, S.; Fahlberg, M. D.; Cosgriff, S.; Lee, S. H.; Abbott, G.; Zhu, H.; Minasian, N. H.; Vote, A. S.; Martino, N.; Yun, S. H.
10.1101/2022.06.03.494697 — bioengineering — Posted on 2022-06-04
3463 Optimization of a Translational Murine Model of Closed-head Traumatic Brain Injury
Lassiter, E.; Arulraja, E. K.; Chaparro, E.; Cantillana, V.; Gupta, R.; Faw, T. D.; Mace, B. E.; Laskowitz, D. T.; Kolls, B. J.
10.1101/2022.06.02.494542 — neuroscience — Posted on 2022-06-04
3464 Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr682 phosphorylated APP βCTF
Im, E.; Jiang, Y.; Stavrides, P.; Darji, S.; Erdjument-Bromage, H.; Neubert, T.; Bordi, M.; Choi, J. Y.; Lee, J.-H.; Nixon, R.
10.1101/2022.06.02.494546 — neuroscience — Posted on 2022-06-04
3467 Mutations in OsRZF1, encoding a zinc-finger protein, causes reduced magnesium uptake in roots and translocation to shoots in rice
Kobayashi, N. I.; Takagi, H.; Yang, X.; Nishizawa-Yokoi, A.; Hoshina, T.; Oonishi, T.; Suzuki, H.; Iwata, R.; Toki, S.; Nakanishi, T. M.; Tanoi, K.
10.1101/2022.06.02.494605 — plant biology — Posted on 2022-06-04
3474 Mixed origin of juvenile Atlantic cod (Gadus morhua) along the Swedish west coast
Henriksson, S.; Pereyra, R. T.; Sodeland, M.; Ortega-Martinez, O.; Knutsen, H.; Wennhage, H.; Andre, C.
10.1101/2022.06.03.494672 — genomics — Posted on 2022-06-04
3479 Understanding spatiotemporal effects of food supplementation on host-parasite interactions using community-based science
Knutie, S. A.; Bertone, M. A.; Bahouth, R.; Webb, C.; Mehta, M.; Nahom, M.; Barta, R. M.; Ghai, S.; Balenger, S. L.; Butler, M. W.; Kennedy, A. C.; Schultz, E. M.; Taff, C. C.; Albery, G. F.
10.1101/2022.06.02.494595 — ecology — Posted on 2022-06-04
3480 Heat stress does not induce wasting symptoms in the giant California sea cucumber (Apostichopus californicus)
Taylor, D.; Farr, J. J.; Lim, E. G.; Fleet, J. L.; Smith Wuitchik, S. J.; Wuitchik, D. M.
10.1101/2022.06.02.494586 — ecology — Posted on 2022-06-04
3483 Extrinsic control of the early postnatal CA1 hippocampal circuits
Leprince, E.; Dard, R. F.; Mortet, S.; Filippi, C.; Giorgi-Kurz, M.; Lenck-Santini, P.-P.; Picardo, M. A.; Bocchio, M.; Baude, A.; Cossart, R.
10.1101/2022.06.03.494656 — neuroscience — Posted on 2022-06-04
3485 Feasibility of 3T layer-dependent fMRI with GE-BOLD using NORDIC and phase regression
Knudsen, L.; Bailey, C. J.; Blicher, J. U.; Yang, Y.; Zhang, P.; Lund, T. E.
10.1101/2022.06.02.494602 — neuroscience — Posted on 2022-06-04
3487 N-hydroxy pipecolic acid methyl ester is involved in Arabidopsis immunity
Mohnike, L.; Huang, W.; Worbs, B.; Feussner, K.; Zhang, Y.; Feussner, I.
10.1101/2022.06.03.494702 — plant biology — Posted on 2022-06-04
3488 MarpolBase Expression: A Web-based, Comprehensive Platform for Visualization and Analysis of Transcriptomes in the Liverwort Marchantia polymorpha
Kawamura, S.; Romani, F.; Yagura, M.; Mochizuki, T.; Sakamoto, M.; Yamaoka, S.; Nishihama, R.; Nakamura, Y.; Yamato, K. T.; Bowman, J. L.; Kohchi, T.; Tanizawa, Y.
10.1101/2022.06.03.494633 — plant biology — Posted on 2022-06-04
3490 An Accelerometer Based Heart Monitor to Measure Changes of the Autonomic Nervous System
Babenko, V.; Dundon, N. M.; Macy, A.; Stump, A.; Turbow, M.; Cieslak, M.; Grafton, S. T.
10.1101/2022.06.02.494453 — physiology — Posted on 2022-06-04
3491 Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation
West, J.; Rentzeperis, F.; Adam, C.; Bravo, R.; Luddy, K. A.; Robertson-Tessi, M.; Anderson, A. R. A.
10.1101/2022.06.03.493752 — cancer biology — Posted on 2022-06-04
3492 Kinetic error suppression of PCR
Aoyanagi, H.; Pigolotti, S.; Ono, S.; Toyabe, S.
10.1101/2022.06.02.494611 — biophysics — Posted on 2022-06-04
3494 Towards generalizable prediction of antibody thermostability using machine learning on sequence and structure features
Harmalkar, A.; Rao, R. M.; Honer, J.; Deisting, W.; Anlahr, J.; Hoenig, A.; Czwikla, J.; Sienz-Widmann, E.; Rau, D.; Rice, A.; Riley, T. P.; Li, D.; Catterall, H. B.; Tinberg, C. E.; Gray, J. J.; Wei, K. Y.
10.1101/2022.06.03.494724 — bioinformatics — Posted on 2022-06-04
3497 Natural helminth infections reduce relative abundance of inflammation-inducing Prevotella in wild primates
Cizauskas, C. A.; Washburne, A. D.; Knelman, J. E.; Hansen, C. B.; Nderitu, A. M.; Esinyon, P. L.; Dobson, A.; Graham, A. L.
10.1101/2022.06.02.494558 — ecology — Posted on 2022-06-04
3499 Novel insights into the fundamentals of palatal shelf elevation dynamics in normal mouse embryos
Goering, J. P.; Moedritzer, M.; Stetsiv, M.; Isai, D. G.; Hufft-Martinez, B. M.; Umar, Z.; Rickabaugh, M. K.; Keselman, P.; Chauhan, M.; Brooks, W. M.; Fischer, K. J.; Czirok, A.; Saadi, I.
10.1101/2022.06.02.494562 — developmental biology — Posted on 2022-06-04
3500 Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation
Chakrabarti, R.; Fung, T. S.; Kang, T.; Pallijeff, P. W.; Suomalainen, A.; Usherwood, E. J.; Higgs, H.
10.1101/2022.06.03.494723 — cell biology — Posted on 2022-06-04
3503 Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by in vitro Cellular Studies and in vivo PET Imaging
Zhang, H.; Zammit, M.; Kao, C.-M.; Govind, A. P.; Mitchell, S.; Holderman, N.; Bhuiyan, M.; Freifelder, R.; Zhuang, X.; Mukherjee, J.; Chen, C.-T.; Green, W.
10.1101/2021.12.08.471775 — neuroscience — Posted on 2022-06-04
3506 Structure-based discovery of selective histone deacetylase (HDAC) 3 and 4 inhibitors
Agarwal, R.; Pattarawat, P.; Duff, M. R.; Wang, H.-C. R.; Baudry, J.; Smith, J.
10.1101/2022.05.31.494169 — cancer biology — Posted on 2022-06-04
3511 Three-dimensional structure of the kinetochore-fibers in human mitotic spindles
Kiewisz, R.; Fabig, G.; Conway, W.; Baum, D.; Needleman, D.; Muller-Reichert, T.
10.1101/2021.11.13.468347 — cell biology — Posted on 2022-06-04
3512 Accurate Direct PCR with Arabidopsis and rice
Lynagh, P.; Osuna-Kleist, P.; Wang, B.; Malagon, E.; Anleu Gil, M. X.; Comai, L.
10.1101/2021.07.16.452406 — molecular biology — Posted on 2022-06-04
3513 The developmentally-timed decay of an essential microRNA family is seed sequence-dependent
Donnelly, B.; Yang, B.; Grimme, A. L.; Vieux, K.-F.; Liu, C.-Y.; Zhou, L.; McJunkin, K.
10.1101/2021.11.19.469346 — molecular biology — Posted on 2022-06-04
3515 Mitochondrial Transcription Factor A Regulates Foxp3+ T Cell Mediated Maintenance of CD4+ T Cell Landscapes and Immunological Aging
Guo, K.; Wang, Z.; Debnath, T.; Mehta, H.; Abrham, E.; Even, Z.; Rahman, M.; Lund Da Costa, A.; Jain, S.; Wang, X.; Hur, J.; Murugaiyan, G.; Ting, A. T.; Brown-Borg, H.; Jurivich, D. A.; Khan, N.; Mathur, R.
10.1101/2022.03.08.483517 — immunology — Posted on 2022-06-04
3516 Multiscale computer modeling of spreading depolarization in brain slices
Kelley, C.; Newton, A. J. H.; Hrabetova, S.; McDougal, R. A.; Lytton, W. W.
10.1101/2022.01.20.477118 — neuroscience — Posted on 2022-06-04
3517 Identification of novel basil downy mildew resistance genes using de novo comparative transcriptomics
Allen, K. S.; DeIulio, G. A.; Pyne, R.; Maman, J.; Guo, L.; Wick, R. L.; Simon, J.; Gershenson, A.; Ma, L.-J.
10.1101/2022.05.23.491563 — plant biology — Posted on 2022-06-04
3518 Characterization of prohibitins as novel target to block asexual and sexual stage growth of Plasmodium falciparum
Saini, M.; Ngwa, C. J.; Marothia, M.; Kumari, V.; Pandey, K.; Pati, S.; Ranganathan, A.; Pradel, G.; Singh, S.
10.1101/2022.06.02.494630 — molecular biology — Posted on 2022-06-04
3520 Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences
Chen, S.; Huang, C.; Liao, G.; Sun, H.; Xie, Y.; Wang, J.; He, M.; Hu, H.; Dai, Z.; Ren, X.; Zeng, X.; Zeng, Q.; Zhang, G.; Liao, C.; Xie, W.; Shen, S.; Li, S.; Peng, S.; Kuang, D.; Zhao, Q.; Duda, D.; Kuang, M.
10.1101/2022.06.02.494526 — immunology — Posted on 2022-06-04
3521 RBFOX2 deregulation promotes pancreatic cancer metastasis through alternative splicing
Maurin, M.; Ranjouri, M.; Martin, K.; Miner, R.; Newberg, J. Y.; Du, D.; Centeno, B.; Fleming, J. B.; Yu, X. B.; Guccione, E.; Black, M.; Mann, K. M.
10.1101/2022.06.01.494386 — cancer biology — Posted on 2022-06-04
3522 Comparative analysis of the caecal tonsil transcriptome in two hen lines experimentally infected with Salmonella Enteritidis
Cazals, A.; RAU, A.; ESTELLE, J.; BRUNEAU, N.; COVILLE, J.-L.; MENANTEAU, P.; ROSSIGNOL, M.-N.; JARDET, D.; BEVILACQUA, C.; BEDHOM, B.; VELGE, P.; CALENGE, F.
10.1101/2022.06.03.494662 — genetics — Posted on 2022-06-03
3523 FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.
Pifer, P. M.; Yang, L.; Kumar, M.; Xie, T.; Frederick, M.; Hefner, A.; Beadle, B.; Molkentine, D.; Molkentine, J.; Dhawan, A.; Abdelhakiem, M.; Osman, A. A.; Myers, J. N.; Pickering, C. R.; Sandulache, V. C.; Heymach, J.; Skinner, H. D.
10.1101/2022.06.03.494547 — cancer biology — Posted on 2022-06-03
3526 Repetitive elements in the era of biodiversity genomics: insights from 600+ insect genomes
Sproul, J. S.; Hotaling, S.; Heckenhauer, J.; Powell, A.; Larracuente, A. M.; Kelley, J. L.; Pauls, S. U.; Frandsen, P. B.
10.1101/2022.06.02.494618 — genomics — Posted on 2022-06-03
3527 A recurrent de novo splice site variant involving DNM1 alternative exon 10a causes developmental and epileptic encephalopathy through a dominant-negative mechanism
Parthasarathy, S.; Ruggiero, S. M.; Gelot, A.; Soardi, F. C.; Ribeiro, B. F.; Pires, D. E.; Ascher, D. B.; Schmitt, A.; Rambaud, C.; Xie, H. M.; Lusk, L.; Wilmarth, O.; McDonnell, P. P.; Juarez, O. A.; Grace, A. N.; Buratti, J.; Mignot, C.; Gras, D.; Nava, C.; Pierce, S. R.; Keren, B.; Kennedy, B. C.; Pena, S. D.; Helbig, I.; Cuddapah, V. A.
10.1101/2022.06.02.492389 — genetics — Posted on 2022-06-03
3531 Designed allosteric protein logic
Plaper, T.; Merljak, E.; Fink, T.; Lainscek, D.; Satler, T.; Jazbec, V.; Bencina, M.; Jerala, R.
10.1101/2022.06.03.494683 — synthetic biology — Posted on 2022-06-03
3534 Human hematopoietic stem cell vulnerability to ferroptosis
Zhao, J.; Jia, Y.; Mahmut, D.; Deik, A. A.; Jeanfavre, S.; Clish, C. B.; Sankaran, V. G.
10.1101/2022.06.03.494357 — genetics — Posted on 2022-06-03
3535 Genetic architecture of trophic adaptations in cichlid fishes
DeLorenzo, L.; DeBrock, V.; Carmona Baez, A.; Ciccotto, P. J.; Peterson, E. N.; Stull, C.; Roberts, N. B.; Roberts, R. B.; Powder, K. E.
10.1101/2022.06.03.494688 — evolutionary biology — Posted on 2022-06-03
3536 Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator
Knabl, P.; Schauer, A.; Pomreinke, A. P.; Zimmermann, B.; Rogers, K. W.; Mueller, P.; Genikhovich, G.
10.1101/2022.06.03.494682 — developmental biology — Posted on 2022-06-03
3537 MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles
Laguillo-Diego, A.; Kiewisz, R.; Marti-Gomez, C.; Baum, D.; Muller-Reichert, T.; Vernos, I.
10.1101/2022.06.03.494715 — cell biology — Posted on 2022-06-03
3538 Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2.
Ozcelik, E.; Kalayci, A.; Celik, B.; Avci, A.; Akyol, H.; Kilic, I. B.; Guzel, T.; Cetin, M.; Tuzlakoglu Ozturk, M.; Caliskaner, Z. O.; Tombaz, M.; Yoleri, D.; Konu, O.; Kandilci, A.
10.1101/2022.06.03.494677 — cell biology — Posted on 2022-06-03
3540 Condensin pinches a short negatively supercoiledDNA loop during each round of ATP usage
Martinez-Garcia, B.; Dyson, S.; Segura, J.; Gutierrez-Escribano, P.; Aragon, L.; Roca, J.
10.1101/2022.06.03.494647 — molecular biology — Posted on 2022-06-03
3542 Age exacerbates SARS-CoV-2-induced blood-brain barrier leakage and neuropsychiatric dysfunction
Niladhuri, S. B.; Clare, G. O.; Robinson, K. F.; Class, J.; Almousawi, A. A.; Trevino, T. N.; Marottoli, F.; Tai, L. M.; Richner, J. M.; Lutz, S. E.
10.1101/2022.06.02.494552 — neuroscience — Posted on 2022-06-03
3544 Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC
Liu, S.; Li, L.; Zhang, F.; van Sambeek, B.; Appleton, E.; Ng, A. H. M.; Khoshakhlagh, P.; Chen, Y.; Garcia-Corral, M.; Wu, C.-T.; Huang, J. Y.; Tan, Y.; Chao, G.; Aach, J.; Tam, J.; Lim, E. T.; Raychaudhuri, S.; Church, G.
10.1101/2022.06.03.494617 — bioengineering — Posted on 2022-06-03
3554 Quantum biological insights into CRISPR-Cas9 sgRNA efficiency from explainable-AI driven feature engineering
Noshay, J. M.; Walker, T.; Romero, J.; Prates, E.; Eckert, C.; Irle, S.; Kainer, D.; Jacobson, D. A.
10.1101/2022.06.03.494572 — systems biology — Posted on 2022-06-03
3556 Ensemble-specific deficit in neuronal intrinsic excitability in aged mice
Chen, L.; Francisco, T.; Baggetta, A.; Ramirez, S.; Clem, R.; Shuman, T.; Cai, D. J.
10.1101/2022.06.02.494525 — neuroscience — Posted on 2022-06-03
3557 Discovery of host-directed modulators of virus infection by probing the SARSCoV-2-host protein-protein interaction network
Ravindran, V.; Wagoner, J.; Athanasiadis, P.; Den Hartigh, A. B.; Sidorova, J. M.; Ianevski, A.; Fink, S. L.; Frigessi, A.; White, J. M. M.; Polyak, S. J.; Aittokallio, T.
10.1101/2022.06.03.494640 — systems biology — Posted on 2022-06-03
3560 Transcriptional activity is shaped by the chromatin landscapes in Arabidopsis
Jamge, B.; Lorkovic, Z.; Axelsson, E.; Yelagandula, R.; Akimcheva, S.; Berger, F.
10.1101/2022.06.02.494419 — genomics — Posted on 2022-06-03
3561 The histone demethylase KDM3 prevents auto-immune piRNAs production in Drosophila
Casier, K.; Autaa, J.; Guegen, N.; Delmarre, V.; Marie, P. P.; Ronsseray, S.; Carre, C.; Brasset, E.; Teysset, L.; Boivin, A.
10.1101/2022.06.02.494511 — genetics — Posted on 2022-06-03
3563 Distinct antibody responses to endemic coronaviruses pre- and post-SARS-CoV-2 infection in Kenyan infants and mothers
Stoddard, C. I.; Sung, K.; Ojee, E.; Adhiambo, J.; Begnel, E. R.; Slyker, J.; Gantt, S.; Matsen, F. A.; Kinuthia, J.; Wamalwa, D.; Overbaugh, J.; Lehman, D. A.
10.1101/2022.06.02.493651 — microbiology — Posted on 2022-06-03
3564 Population Sequencing Reveals Rht-D1b Contributing the Bigger Seedling Root to Modern Wheat Cultivars
Wang, X.; Zhao, P.; Guo, X.; Liu, Z.; Ma, X.; Zhao, Y.; Lai, X.; Huang, L.; Wang, W.; Han, D.; Kang, Z.; Xu, S.
10.1101/2022.06.02.494553 — plant biology — Posted on 2022-06-03
3565 TSignal: A transformer model for signal peptide prediction
Dumitrescu, A.; Jokinen, E.; Kellosalo, J.; Paavilainen, V.; Lähdesmäki, H.
10.1101/2022.06.02.493958 — bioinformatics — Posted on 2022-06-03
3568 Galaxy Training: A Powerful Framework for Teaching!
Hiltemann, S.; Rasche, H.; Gladman, S.; Hotz, H.-R.; Lariviere, D.; Blankenberg, D.; Jagtap, P. D.; Wollmann, T.; Bretaudeau, A.; Goue, N.; Griffin, T. J.; Royaux, C.; Le Bras, Y.; Mehta, S.; Syme, A. E.; Coppens, F.; Droesbeke, B.; Soranzo, N.; Bacon, W.; Psomopoulos, F. E.; Gallardo-Alba, C.; Davis, J.; Föll, M. C.; Fahrner, M.; Doyle, M. A.; Serrano-Solano, B.; Fouilloux, A. C.; van Heusden, P.; Maier, W.; Clements, D.; Heyl, F.; Grüning, B. A.; Batut, B.; Galaxy Training Network,
10.1101/2022.06.02.494505 — bioinformatics — Posted on 2022-06-03
3572 Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism
McChesney, N.; Barth, J. L.; Rumschlag, J. A.; Tan, J.; Harrington, A.; Noble, K.; McClaskey, C.; Elvis, P.; Vaena, S.; Romeo, M.; Harris, K. C.; Cowan, C. W.; Lang, H.
10.1101/2022.06.02.494499 — neuroscience — Posted on 2022-06-03
3573 Ensemble remodeling supports memory-updating
Mau, W.; Morales-Rodriguez, D.; Dong, Z.; Pennington, Z. T.; Francisco, T.; Baxter, M. G.; Shuman, T.; Cai, D. J.
10.1101/2022.06.02.494530 — neuroscience — Posted on 2022-06-03
3576 Single-shot off-axis full-field optical coherence tomography
Martins Seromenho, E.; Marmin, A.; Facca, S.; Bahlouli, N.; Perrin, S.; Nahas, A.
10.1101/2022.06.02.494183 — biophysics — Posted on 2022-06-03
3577 Osmotic stress response in BetP: How lipids and K+ team up to overcome downregulation
Heinz, V.; Gueler, G.; Leone, V.; Madej, M. G.; Maksimov, S.; Gaertner, R. M.; Rudi, O.; Hamdi, F.; Kastritis, P. L.; Maentele, W.; Kraemer, R.; Forrest, L. R.; Perez, C.; Ziegler, C.
10.1101/2022.06.02.493408 — biophysics — Posted on 2022-06-03
3581 Dynamic DNA methylation reveals novel cis-regulatory elements in murine hematopoiesis
Schönung, M.; Hartmann, M.; Krämer, S.; Stäble, S.; Hakobyan, M.; Kleinert, E.; Aurich, T.; Cobanoglu, D.; Heidel, F. H.; Fröhling, S.; Milsom, M. D.; Schlesner, M.; Lutsik, P.; Lipka, D. B.
10.1101/2022.06.02.493896 — genomics — Posted on 2022-06-03
3584 Plant signals anticipate the induction of the type III secretion system in Pseudomonas syringae pv. actinidiae facilitating efficient temperature-dependent effector translocation
Puttilli, M. R.; Danzi, D.; Correia, C.; Brandi, J.; Cecconi, D.; Manfredi, M.; Marengo, E.; Santos, C.; Spinelli, F.; Polverari, A.; VANDELLE, E.
10.1101/2022.06.01.494460 — microbiology — Posted on 2022-06-03
3590 Pleural macrophages promote recovery from influenza virus infection
Stumpff, J. P.; Kim, S. Y.; Forero, A.; Nishida, A.; Steuerman, Y.; Gat-Viks, I.; Nair, M. G.; Morrison, J.
10.1101/2022.05.25.493482 — microbiology — Posted on 2022-06-03
3591 A multifaceted architectural framework of the mouse claustrum complex
Grimstvedt, J. S.; Shelton, A. M.; Hoerder-Suabedissen, A.; Oliver, D. K.; Berndtsson, C. H.; Blankvoort, S.; Nair, R. R.; Packer, A. M.; Witter, M. P.; Kentros, C. G.
10.1101/2022.06.02.494429 — neuroscience — Posted on 2022-06-03
3593 The reef-building coral Galaxea fascicularis: a new model system for coral symbiosis
Puntin, G.; Craggs, J.; Hayden, R.; Engelhardt, K.; McIlroy, S.; Sweet, M.; Baker, D. M.; Ziegler, M.
10.1101/2022.06.02.494472 — systems biology — Posted on 2022-06-03
3595 Habitat protection and restoration: win-win opportunities for migratory birds in the Northern Andes
Gonzalez, A. M.; Espejo, N.; Armenteras, D.; Hobson, K. A.; Kardynal, K. J.; Mitchell, G.; Mahony, N.; Bishop, C. A.; Negret, P.; Wilson, S.
10.1101/2022.06.01.494397 — ecology — Posted on 2022-06-03
3596 Nanoscopic resolution within a single imaging frame
Torres, E.; Pinto, R.; Linares, A.; Martinez, D.; Abonza, V.; Brito-Alarcon, E.; Calcines-Cruz, C.; Galindo, G.; Torres, D.; Jablonski, M.; Torres-Martinez, H. H.; Martinez, J. L.; Hernandez, H. O.; Ocelotl, J.; Garces, Y.; Barchi, M.; D'Antuono, R.; Boskovic, A.; Dubrovsky, J. G.; Darszon, A.; Buffone, M.; Rodriguez, R.; Rendon-Mancha, J. M.; Wood, C.; Hernandez, A.; Krapf, D.; Crevenna, A. H.; Guerrero, A.
10.1101/2021.10.17.464398 — cell biology — Posted on 2022-06-03
3600 Dynamin forms liquid-like condensates at synapses to support ultrafast endocytosis
Imoto, Y.; Ma, Y.; Itoh, K.; Blumrich, E.-M.; Matsubayashi, H. T.; Liu, J.; Wu, B.; Cousin, M. A.; Ha, T.; Inoue, T.; Watanabe, S.
10.1101/2022.06.01.494432 — neuroscience — Posted on 2022-06-03
3602 Recording large-scale, cellular-resolution neuronal activity from freely-moving mice
Das, A.; Holden, S.; Borovicka, J.; Icardi, J.; Patel, D.; Patel, R.; Raber, J.; Dana, H.
10.1101/2022.06.01.494442 — neuroscience — Posted on 2022-06-03
3604 Comparative phyloproteomics identifies conserved plasmodesmal proteins
Johnston, M. G.; Breakspear, A.; Samwald, S.; Zhang, D.; Papp, D.; Faulkner, C.; de Keijzer, J.
10.1101/2022.06.01.494363 — plant biology — Posted on 2022-06-03
3606 AlphaFold2 reveals commonalities and novelties in protein structure space for 21 model organisms
Bordin, N.; Sillitoe, I.; Nallapareddy, M. V.; Rauer, C.; Lam, S. D.; Waman, V. P.; Sen, N.; Heinzinger, M.; Littmann, M.; Kim, S. S.; Velankar, S.; Steinegger, M.; Rost, B.; Orengo, C.
10.1101/2022.06.02.494367 — bioinformatics — Posted on 2022-06-03
3610 Long-read HiFi Sequencing Correctly Assembles Repetitive heavy fibroin Silk Genes in New Moth and Caddisfly Genomes
Kawahara, A. Y.; Storer, C. G.; Markee, A.; Heckenhauer, J.; Powell, A.; Plotkin, D.; Hotaling, S.; Cleland, T. P.; Dikow, R. B.; Dikow, T.; Kuranishi, R. B.; Messcher, R.; Pauls, S. U.; Stewart, R. J.; Tojo, K.; Frandsen, P. B.
10.1101/2022.06.01.494423 — genomics — Posted on 2022-06-03
3611 Genomic Insights of Bruneian Malays
Azmi, M.; Chen, L.; Idris, A.; Lu, Z. H.
10.1101/2022.06.01.492266 — genomics — Posted on 2022-06-03
3612 Reconsidering the validity of transcriptome-wide association studies
de Leeuw, C.; Werme, J.; Savage, J.; Peyrot, W. J.; Posthuma, D.
10.1101/2021.08.15.456414 — genetics — Posted on 2022-06-03
3615 Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in Drosophila
Fang, H. Y.; Forghani, R.; Clarke, A.; McQueen, P. G.; Chandrasekaran, A.; O'Neill, K. M.; Losert, W.; Papoian, G. A.; Giniger, E.
10.1101/2022.06.01.494414 — neuroscience — Posted on 2022-06-03
3617 NMDAR mediated dynamic changes in m6A inversely correlates with neuronal translation
gowda, N. K. C.; Nawalpuri, B.; Ramakrishna, S.; Jhaveri, V.; Muddashetty, R.
10.1101/2022.06.01.494458 — neuroscience — Posted on 2022-06-03
3618 Motor unit dysregulation following 15 days of unilateral lower limb immobilisation
Inns, T. B.; Bass, J. J.; Hardy, E. J. O.; Stashuk, D. W.; Atherton, P. J.; Phillips, B. E.; Piasecki, M.
10.1101/2022.06.01.494421 — physiology — Posted on 2022-06-03
3619 ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma
Song Green, Y.; Ferreira dos Santos, M. C.; Fuja, D. G.; Reichert, E. C.; Campos, A. R.; Cowman, S.; Kohan, J.; Tripp, S. R.; Leibold, E. A.; Sirohi, D.; Agarwal, N.; Liu, X.; Koh, M. Y.
10.1101/2022.06.01.494206 — cancer biology — Posted on 2022-06-03
3620 Interactions in CSF1-driven Tenosynovial Giant Cell Tumors
van IJzendoorn, D. G. P.; Matusiak, M.; Charville, G. W.; Spierenburg, G.; Varma, S.; Colburg, D. R. C.; van de Sande, M. A. J.; van Langevelde, K.; Mohler, D. G.; Ganjoo, K. N.; Bui, N. Q.; Avedian, R. S.; Bovee, J. V. M. G.; Steffner, R.; West, R. B.; van de Rijn, M.
10.1101/2022.06.01.494428 — cancer biology — Posted on 2022-06-03
3621 The kinetic landscape of human transcription factors
Mamrak, N. E.; Alerasool, N.; Griffith, D.; Holehouse, A. S.; Taipale, M.; Lionnet, T.
10.1101/2022.06.01.494187 — biophysics — Posted on 2022-06-03
3622 Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform
Almogy, G.; Pratt, M.; Oberstrass, F.; Lee, L.; Mazur, D.; Beckett, N.; Barad, O.; Soifer, I.; Perelman, E.; Etzioni, Y.; Sosa, M.; Jung, A.; Clark, T.; Trepagnier, E.; Lithwick-Yanai, G.; Pollock, S.; Hornung, G.; Levy, M.; Coole, M.; Howd, T.; Shand, M.; Farjoun, Y.; Emery, J.; Hall, G.; Lee, S. K.; Sato, T.; Magner, R.; Low, S.; Bernier, A.; Gandi, B.; Stohlman, J.; Nolet, C.; Donovan, S.; Blumenstiel, B.; Cipicchio, M.; Dodge, S.; Banks, E.; Lennon, N.; Gabriel, S.; Lipson, D.
10.1101/2022.05.29.493900 — genomics — Posted on 2022-06-03
3623 A comprehensive single-cell atlas of freshly dissociated human synovium in inflammatory arthritis with an optimized dissociation protocol for prospective fresh synovial biopsy collection
Edalat, S. G.; Gerber, R.; Houtman, M.; Kuret, T.; Izanc, N.; Micheroli, R.; Buerki, K.; Burja, B.; Pauli, C.; Rotar, Z.; Tomsic, M.; Cucnik, S.; Distler, O.; Ospelt, C.; Sodin Semrl, S.; Robinson, M. D.; Frank Bertoncelj, M.
10.1101/2022.06.01.493823 — genomics — Posted on 2022-06-03
3626 Existing caribou habitat and demographic models are poorly suited for Ring of Fire impact assessment: A roadmap for improving the usefulness, transparency, and availability of models for conservation
Dyson, M. E.; Endicott, S.; Simpkins, C.; Turner, J. W.; Avery-Gomm, S.; Johnson, C. A.; Leblond, M.; Neilson, E.; Rempel, R. S.; Wiebe, P.; Baltzer, J. L.; Stewart, F. E. C.; Hughes, J.
10.1101/2022.06.01.494350 — ecology — Posted on 2022-06-03
3627 Delayed recovery and host specialization may spell disaster for coral-fish mutualism
Froehlich, C. Y. M.; Klanten, O. S.; Hing, M. L.; Dowton, M.; Wong, M. Y. L.
10.1101/2022.06.01.494455 — ecology — Posted on 2022-06-03
3629 Deletion of CD226 in Foxp3+ T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function
Thirawatananond, P.; Brown, M.; Sachs, L.; Arnoletti, J.; Yeh, W.-I.; Posgai, A. L.; Shapiro, M.; Chen, Y.-G.; Brusko, T.
10.1101/2022.06.02.494443 — immunology — Posted on 2022-06-03
3630 Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells
Kunzli, M.; O'Flanagan, S.; LaRue, M.; Talukder, P.; Dileepan, T.; Soerens, A.; Quarnstrom, C.; Wijeyesinghe, S.; Ye, Y.; McPartlan, J.; Mitchell, J.; Mandl, C.; Vile, R.; Jenkins, M.; Ahmed, R.; Vezys, V.; Chahal, J.; Masopust, D.
10.1101/2022.06.02.494574 — immunology — Posted on 2022-06-03
3631 Genetic or transcranial magnetic stimulation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration
Boato, F.; Guan, X.; Zhu, Y.; Ryu, Y.; Voutounou, M.; Rynne, C.; Freschlin, C. R.; Zumbo, P.; Betel, D.; Matho, K. S.; Makarov, S. N.; Wu, Z.; Son, Y.-J.; Nummenmaa, A.; Huang, J. Z.; Edwards, D. J.; Zhong, J.
10.1101/2022.06.01.494346 — neuroscience — Posted on 2022-06-03
3632 Inter-regional delays fluctuate in the human cerebral cortex
Moon, J.-Y.; Muesch, K.; Schroeder, C.; Valiante, T.; Honey, C.
10.1101/2022.06.01.494224 — neuroscience — Posted on 2022-06-03
3633 A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry
Keeler, A. B.; Van Deusen, A. L.; Cheng, I.; Williams, C. M.; Goggin, S. M.; Hirt, A. K.; Vradenburgh, S. A.; Fread, K. I.; Puleo, E. A.; Jin, L.; Calhan, O. Y.; Deppmann, C. D.; Zunder, E. R.
10.1101/2022.06.01.494445 — neuroscience — Posted on 2022-06-03
3637 3D (x-y-t) Raman imaging of tomato fruit cuticle: microchemistry during development
Gonzalez Moreno, A.; Dominguez, E.; Mayer, K.; Xiao, N.; Bock, P.; Heredia, A.; Gierlinger, N.
10.1101/2022.06.01.494410 — biophysics — Posted on 2022-06-03
3638 Dkk1 inhibition normalizes limb phenotypes in a mouse model of Fzd2 associated omodysplasia Robinow syndromes
Liegel, R.; Michalski, M. N.; Vaidya, S.; Bittermann, E.; Finnerty, E.; Menke, C.; Diegel, C. R. N.; Zhong, Z. A.; Williams, B. O.; Stottmann, R.
10.1101/2022.06.02.494481 — developmental biology — Posted on 2022-06-03
3639 An epigenetic barrier sets the timing of human neuronal maturation
Ciceri, G.; Cho, H.; Kshirsagar, M.; Baggiolini, A.; Aromolaran, K. A.; Walsh, R. M.; Goldstein, P. A.; Koche, R. P.; Leslie, C. S.; Studer, L.
10.1101/2022.06.02.490114 — developmental biology — Posted on 2022-06-03
3640 Reconstituting human somitogenesis in vitro
Yamanaka, Y.; Yoshioka-Kobayashi, K.; Hamidi, S.; Munira, S.; Sunadome, K.; Zhang, Y.; Kurokawa, Y.; Mieda, A.; Thompson, J. L.; Kerwin, J.; Lisgo, S.; Yamamoto, T.; Moris, N.; Martinez-Arias, A.; Tsujimura, T.; Alev, C.
10.1101/2022.06.03.494621 — developmental biology — Posted on 2022-06-03
3642 Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons
Hergenreder, E.; Zorina, Y.; Zhao, Z.; Munguba, H.; Calder, E. L.; Baggiolini, A.; Minotti, A. P.; Walsh, R. M.; Liston, C.; Levitz, J.; Garippa, R.; Chen, S.; Ciceri, G.; Studer, L.
10.1101/2022.06.02.494616 — neuroscience — Posted on 2022-06-03
3643 Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature
Dharan, R.; Goren, S.; Cheppali, S. K.; Shendrik, P.; Brand, G.; Yu, L.; Kozlov, M. M.; Sorkin, R.
10.1101/2022.06.02.494291 — biophysics — Posted on 2022-06-03
3644 Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Ruppel, A.; Woerthmueller, D.; Misiak, V.; Kelkar, M.; Wang, I.; Moreau, P.; Mery, A.; Revilloud, J.; Charras, G.; Cappello, G.; Boudou, T.; Schwarz, U. S.; Balland, M.
10.1101/2022.06.01.494332 — biophysics — Posted on 2022-06-03
3645 Identification of Bacteriophage Genome Pieceswith Representation Learning
Bai, Z.; Zhang, Y.-z.; Miyano, S.; Yamaguchi, R.; Fujimoto, K.; Uematsu, S.; Imoto, S.
10.1101/2021.09.25.461359 — bioinformatics — Posted on 2022-06-03
3647 Leveraging a natural murine meiotic drive to suppress invasive populations
Gierus, L.; Birand, A.; Bunting, M. D.; Godahewa, G. I.; Piltz, S. G.; Oh, K. P.; Piaggio, A. J.; Threadgill, D. W.; Godwin, J.; Edwards, O.; Cassey, P.; Ross, J. V.; Prowse, T. A. A.; Thomas, P. Q.
10.1101/2022.05.31.494104 — genetics — Posted on 2022-06-03
3648 BIN1/Amphiphysin 2 and ezrin drive filopodia-like structures in myoblasts
Picas, L.; Comunale, F.; Andre-Arpin, C.; Bousquet, H.; Tsai, F.-C.; Rico, F.; Maiuri, P.; Pernier, J.; Bodin, S.; Nicot, A.-S.; Laporte, J.; Bassereau, P.; Goud, B.; Gauthier-Rouviere, C.; Miserey, S.
10.1101/2022.03.21.485158 — cell biology — Posted on 2022-06-03
3649 Inhibition of Tgfβ signaling enables durable ventricular pacing by TBX18 gene transfer
Fan, J.; Kim, N. K.; Fernandez, N.; Kim, T. Y.; Li, J.; Wolfson, D.; Cho, H. C.
10.1101/2022.06.02.493572 — cell biology — Posted on 2022-06-03
3651 PPP2R1A Regulates Migration Persistence through the WAVE Shell Complex
Wang, Y.; Chiappetta, G.; Guerois, R.; Romero, S.; Krause, M.; Dessalles, C.; Babataheri, A.; Barakat, A. I.; Vinh, J.; Polesskaya, A.; Gautreau, A. M.
10.1101/2022.06.02.494622 — cell biology — Posted on 2022-06-03
3652 VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules
Ramirez-Rios, S.; Choi, S. R.; Sanyal, C.; Blum, T.; Bosc, C.; Krichen, F.; Denarier, E.; Soleilhac, J.-M.; Blot, B.; Janke, C.; Stoppin-Mellet, V.; Magiera, M. M.; Arnal, I.; Steinmetz, M. O.; Moutin, M.-J.
10.1101/2022.06.02.494516 — cell biology — Posted on 2022-06-03
3653 A mechanism for the elimination of IgE plasma cells
Wade-Vallance, A. K.; Yang, Z.; Libang, J. B.; Robinson, M. J.; Tarlinton, D. M.; Allen, C. D. C.
10.1101/2022.05.11.491510 — immunology — Posted on 2022-06-03
3654 CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
Leng, K.; Rose, I. V. L.; Kim, H.; Xia, W.; Romero-Fernandez, W.; Rooney, B.; Koontz, M.; Li, E.; Ao, Y.; Wang, S.; Krawczyk, M.; TCW, J.; Goate, A.; Zhang, Y.; Ullian, E. M.; Sofroniew, M. V.; Fancy, S. P. J.; Schrag, M. S.; Lippmann, E. S.; Kampmann, M.
10.1101/2021.08.23.457400 — neuroscience — Posted on 2022-06-03
3655 Enhancer architecture and chromatin accessibility constrain phenotypic space during development
Galupa, R.; Alvarez-Canales, G.; Borst, N. O.; Fuqua, T.; Gandara, L.; Misunou, N.; Richter, K.; Alves, M. R. P.; Karumbi, E.; Perkins, M. L.; Kocijan, T.; Rushlow, C. A.; Crocker, J.
10.1101/2022.06.02.494376 — developmental biology — Posted on 2022-06-02
3656 Route of mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells
Kunzli, M.; O'Flanagan, S.; LaRue, M.; Talukder, P.; Dileepan, T.; Soerens, A.; Quarnstrom, C.; Wijeyesinghe, S.; Ye, Y.; McPartlan, J.; Mitchell, J.; Mandl, C.; Vile, R.; Jenkins, M.; Ahmed, R.; Vezys, V.; Chahal, J.; Masopust, D.
10.1101/2022.06.02.494574 — immunology — Posted on 2022-06-02
3658 Association of Striatal Connectivity Gradients to Functional Domains Across Psychiatric Disorders
Mulders, P. C. R.; van Eijndhoven, P. F. P.; van Oort, J.; Oldehinkel, M.; Duyser, F. A.; Kist, J. D.; Collard, R. M.; Vrijsen, J. N.; Haak, K. V.; Beckmann, C. F.; Tendolkar, I.; Marquand, A. F.
10.1101/2022.06.02.494510 — neuroscience — Posted on 2022-06-02
3659 A unique single nucleotide polymorphism in Agouti Signalling Protein (ASIP) gene changes coat colour of Sri Lankan Leopard (Panthera pardus kotiya) to dark black
Bandaranayake, P. C. G.; Sooriyabandara, M. G. C.; Bandaranayake, A. U.; Jayasundara, S. M.; Hathurusinghe, H. A. B. M.; Marasinghe, M. S. L. R. P.; Prasad, G. A. T.; Abeywardana, V. P. M. K.; Pinidiya, M. A.; Nilanthi, R. M. R.
10.1101/2022.06.02.494537 — genomics — Posted on 2022-06-02
3660 Stable and ancient endocytic structures navigate the complex pellicle of apicomplexan parasites
Koreny, L.; Mercado-Saavedra, B. N.; Klinger, C. M.; Barylyuk, K.; Butterworth, S.; Hirst, J.; Rivera-Cuevas, Y.; Zaccai, N. R.; Holzer, V. J. C.; Klingl, A.; Dacks, J. B.; Carruthers, V. B.; Robinson, M. S.; Gras, S.; Waller, R. F.
10.1101/2022.06.02.494549 — cell biology — Posted on 2022-06-02
3662 The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme induced peroxidase.
Talyuli, O. A. C.; Oliveira, J. H. M.; Bottino-Rojas, V.; Silveira, G. O.; Alvarenga, P. H.; Kantor, A. M.; Paiva-SIlva, G. O.; Barillas-Mury, C.; Oliveira, P. L.
10.1101/2022.06.02.494599 — microbiology — Posted on 2022-06-02
3663 The sulfur cycle connects microbiomes and biogeochemistry in deep-sea hydrothermal plumes
Zhou, Z.; Tran, P. Q.; Adams, A. M.; Kieft, K.; Breier, J. A.; Sinha, R. K.; Krishnan, K. P.; Kurian, P. J.; Fortunato, C. S.; Sheik, C. S.; Huber, J. A.; Li, M.; Dick, G. J.; Anantharaman, K.
10.1101/2022.06.02.494589 — microbiology — Posted on 2022-06-02
3664 Deletion of CD226 in Foxp3+ T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function
Thirawatananond, P.; Brown, M.; Sachs, L.; Arnoletti, J.; Yeh, W.-I.; Posgai, A. L.; Shapiro, M.; Chen, Y.-G.; Brusko, T.
10.1101/2022.06.02.494443 — immunology — Posted on 2022-06-02
3665 Computationally-guided design and selection of ribosomal active site mutants with high activity
Kofman, C.; Watkins, A. M.; Kim, D. S.; Wooldredge, A. C.; Karim, A. S.; Das, R. M.; Jewett, M. C.
10.1101/2022.06.02.493746 — synthetic biology — Posted on 2022-06-02
3667 Wheat pollen uptake of CRISPR/Cas9 RNP-PDMAEMA nanoassemblies results in targeted loss of gene function in progeny
Gogoi, N.; Kanwal, M.; Norman, M.; Downs, J.; Ahmad, N.; Mago, R.; Bariana, H.; Muellner, M.; Bansal, U.; Jones, B. J.
10.1101/2022.06.02.494465 — plant biology — Posted on 2022-06-02
3672 Parallelization with Dual-Trap Single-Column Configuration Maximizes Throughput of Proteomic Analysis
Kreimer, S.; Haghani, A.; Binek, A.; Hauspurg, A.; Seyedmohammad, S.; Rivas, A.; Momenzadeh, A.; Meyer, J.; Raedschelders, K.; Van Eyk, J. E.
10.1101/2022.06.02.494601 — biochemistry — Posted on 2022-06-02
3675 TDP 2 modulates the expression of estrogen-responsive oncogenes
Manguso, N.; Kim, M.; Joshi, N.; Al Mahmud, R.; Cortes-Ledesma, F.; Cui, X.; Yamada, S.; Ito, J.; Takeda, S.; Giuliano, A. E.; You, S.; Tanaka, H.
10.1101/2022.06.01.494417 — molecular biology — Posted on 2022-06-02
3677 Mystery of fatal "Staggering disease" unravelled: Novel rustrela virus causes severe encephalomyelitis in domestic cats
Matiasek, K.; Pfaff, F.; Weissenboeck, H.; Wylezich, C.; Kolodziejek, J.; Tengstrand, S.; Ecke, F.; Nippert, S.; Starcky, P.; Litz, B.; Nessler, J.; Wohlsein, P.; Baumbach, C.; Mundhenk, L.; Aebischer, A.; Reiche, S.; Weidinger, P.; Olofsson, K. M.; Rohdin, C.; Weissenbacher-Lang, C.; Matt, J.; Rosati, M.; Flegel, T.; Hoernfeldt, B.; Hoeper, D.; Ulrich, R. G.; Nowotny, N.; Beer, M.; Ley, C.; Rubbenstroth, D.
10.1101/2022.06.01.494454 — microbiology — Posted on 2022-06-02
3678 Roles of RodZ and Class A PBP1b in the Assembly and Regulation of the Peripheral Peptidoglycan Elongasome in Ovoid-Shaped Cells of Streptococcus pneumoniae D39
Lamanna, M. M.; Manzoor, I.; Joseph, M.; Ye, Z. A.; Benedet, M.; Zanardi, A.; Ren, Z.; Wang, X.; Massidda, O.; Tsui, H.-C. T.; Winkler, M. E.
10.1101/2022.06.01.494439 — microbiology — Posted on 2022-06-02
3679 Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain
Kovacs, M. A.; Cowan, M. N.; Babcock, I. W.; Sibley, L. A.; Still, K.; Batista, S. J.; Labuzan, S. A.; Sethi, I.; Harris, T. H.
10.1101/2022.06.02.494581 — immunology — Posted on 2022-06-02
3683 Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces
Deshpande, A.; Loth, M.; Sidiropoulos, D. N.; Zhang, S.; Yuan, L.; Bell, A.; Zhu, Q.; Ho, W. J.; Santa-Maria, C. A.; Gilkes, D. M.; Williams, S.; Uytingco, C.; Chew, J.; Hartnett, A.; Bent, Z.; Favorov, A. V.; Popel, A. S.; Yarchoan, M.; Zheng, L.; Jaffee, E. M.; Anders, R.; Danilova, L.; Stein-O'Brien, G.; Kagohara, L. T.; Fertig, E. J.
10.1101/2022.06.02.490672 — bioinformatics — Posted on 2022-06-02
3684 Secretoglobin family 1D member 2 (SCGB1D2) protein inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease
Strausz, S.; Blacker, G.; Galloway, S.; Hansen, P.; Jones, S.; Sanders, E.; Sinnott-Armstrong, N.; Gen, F.; Weissman, I. L.; Daly, M. J.; Aivelo, T.; Tal, M.; Ollila, H. M.
10.1101/2022.05.27.493784 — genetics — Posted on 2022-06-02
3687 Sensitive bacterial Vm sensors revealed the excitability of bacterial Vm and its role in antibiotic tolerance
Jin, X.; Zhang, X.; Ding, X.; Tian, T.; Tseng, C.-K.; Luo, X.; Chen, X.; Lo, C.-J.; Leake, M. C.; Bai, F.
10.1101/2022.06.02.494477 — microbiology — Posted on 2022-06-02
3688 Niclosamide loaded Eudragit EPO nanoparticles show enhanced Candida biofilm penetration, trigger biofilm detachment and protect from mucosal candidiasis
Sutar, Y.; Nabeela, S.; Singh, S.; Alqarihi, A.; Solis, N. V.; Gebremariam, T.; Filler, S.; Ibrahim, A.; Date, A.; Uppuluri, P.
10.1101/2022.06.02.494588 — microbiology — Posted on 2022-06-02
3691 A complete allosteric map of a GTPase switch in its native network
Mathy, C. J. P.; Mishra, P.; Flynn, J. M.; Perica, T.; Mavor, D.; Bolon, D. N. A.; Kortemme, T.
10.1101/2022.04.13.488230 — biophysics — Posted on 2022-06-02
3696 The admixture histories of Cabo Verde
Laurent, R.; Szpiech, Z. A.; da Costa, S. S.; Thouzeau, V.; Fortes-Lima, C. A.; Dessarps-Freichey, F.; Lemee, L.; Utge, J.; Rosenberg, N. A.; Baptista, M.; Verdu, P.
10.1101/2022.04.11.487833 — genetics — Posted on 2022-06-02
3697 Impact of crowding on the diversity of expanding populations
Schreck, C. F.; Fusco, D.; Karita, Y.; Martis, S.; Kayser, J.; Duvernoy, M.-C.; Hallatschek, O.
10.1101/743534 — evolutionary biology — Posted on 2022-06-02
3699 Cleavage of histone H2A during embryonic stem cell differentiation destabilizes nucleosomes to counteract gene activation
Coradin, M.; Cesare, J.; Lan, Y.; Zhu, Z.; Lund, P. J.; Sidoli, S.; Kori, Y.; Lu, C.; Porter, E. G.; Roberts, C. W. M.; Garcia, B. A.
10.1101/2021.08.10.455684 — developmental biology — Posted on 2022-06-02
3700 Manganese is a Physiologically Relevant TORC1 Activator in Yeast and Mammals.
Nicastro, R.; Gaillard, H.; Zarzuela, L.; Peli-Gulli, M.-P.; Fernandez-Garcia, E.; Tome, M.; Garcia-Rodriguez, N.; Duran, R. V.; De Virgilio, C.; Wellinger, R. E.
10.1101/2021.12.09.471923 — cell biology — Posted on 2022-06-02
3701 Targeting Apollo-NADP+ to image NADPH generation in pancreatic beta-cell organelles
Chang, H. H.; Bennett, A. M.; Cameron, W. D.; Floro, E.; Au, A.; McFaul, C. M.; Yip, C. M.; Rocheleau, J. V.
10.1101/2022.04.27.489691 — cell biology — Posted on 2022-06-02
3705 Reemergence of the Murine Bacterial Pathogen Chlamydia muridarum in Laboratory Mouse Colonies
Mishkin, N.; Ricart Arbona, R. J.; Carrasco, S. E.; Lawton, S.; Henderson, K. S.; Momtsios, P.; Sigar, I. M.; Ramsey, K. H.; Cheleuitte-Nieves, C.; Monette, S.; Lipman, N. S.
10.1101/2022.05.16.491822 — microbiology — Posted on 2022-06-02
3706 The Nucleocapsid Protein Of SARS-CoV-2, Combined With ODN-39M, Is A Potential Component For An Intranasal Bivalent Pancorona Vaccine
Lobaina, Y.; Chen, R.; Suzarte, E.; Ai, P.; Huerta, V.; Musacchio, A.; Silva, R.; Tan, C.; Martin, A.; Lazo, L.; Guillen, G.; Yang, K.; Perera, Y.; Hermida, L.
10.1101/2022.06.02.494502 — immunology — Posted on 2022-06-02
3708 Association of stress-related neural activity and baseline interleukin-6 plasma levels in healthy adults
Voges, J. F.; Mueller-Pinzler, L.; Neis, M.; Luebber, F.; Lange, T.; Hundt, J. E.; Kasten, M.; Kraemer, U. M.; Krach, S.; Rademacher, L.
10.1101/2021.03.26.437134 — neuroscience — Posted on 2022-06-02
3711 OxoScan-MS: Oxonium ion scanning mass spectrometry facilitates plasma glycoproteomics in large scale
White, M. E. H.; Jones, D. M.; de Folter, J.; Aulakh, S. K.; Flynn, H. R.; Krüger, L.; Demichev, V.; Tober-Lau, P.; Kurth, F.; Mülleder, M.; Blanchard, V.; Messner, C. B.; Ralser, M.
10.1101/2022.06.01.494393 — systems biology — Posted on 2022-06-02
3712 Recording gene expression order in DNA by CRISPR addition of retron barcodes
Bhattarai-Kline, S.; Lear, S. K.; Fishman, C. B.; Lopez, S. C.; Lockshin, E.; Schubert, M. G.; Nivala, J.; Church, G.; Shipman, S. L.
10.1101/2021.08.11.455990 — synthetic biology — Posted on 2022-06-02
3714 Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping combined with genome sequence analysis
N'Guessan, A.; Kailasam, S.; Mostefai, F.; Poujol, R.; Grenier, J.-C.; Contini, P.; De Palma, R.; Haber, C.; Stadler, V.; Bourque, G.; Hussin, J.; Shapiro, B. J.; Fritz, J. H.; Piccirillo, C. A.
10.1101/2022.06.01.494373 — genomics — Posted on 2022-06-02
3715 A Multitrait Locus Regulates Sarbecovirus Pathogenesis
Baric, R. S.; Schaefer, A.; Leist, S. R.; Gralinski, L.; Martinez, D.; Winkler, E. S.; Okuda, K.; Hawkins, P. E.; Gully, K. L.; Graham, R. L.; Scobey, T. D.; Bell, T. A.; Hock, P.; Shaw, G. D.; Loome, J. F.; Madden, E. A.; Anderson, E.; Baxter, V.; Taft-Benz, S.; Zweigart, M. R.; May, S. R.; Dong, S.; Clark, M.; Miller, D. R.; Lynch, R.; Heise, M. T.; Tisch, R.; Boucher, R.; Pardo Manuel de Villena, F.; Montgomery, S. A.; Diamond, M. S.; Ferris, M. T.
10.1101/2022.06.01.494461 — microbiology — Posted on 2022-06-02
3716 Outbreak.info Research Library: A standardized, searchable platform to discover and explore COVID-19 resources
Tsueng, G.; Mullen, J.; Alkuzweny, M.; Cano, M. A.; Rush, B.; Haag, E.; Outbreak Curators, ; Latif, A. A.; Zhou, X.; Qian, Z.; Andersen, K. G.; Wu, C.; Su, A. I.; Gangavarapu, K.; Hughes, L. D.
10.1101/2022.01.20.477133 — bioinformatics — Posted on 2022-06-02
3718 Evaluation of folliculin detection by immunohistochemistry in Birt-Hogg-Dube associated kidney tumors
Glykofridis, I. E.; van de Beek, I.; Vos, W.; Kortman, P.; van der Valk, P.; Freire, R.; Houweling, A. C.; Wolthuis, R. M. F.
10.1101/2022.06.01.494402 — genetics — Posted on 2022-06-02
3720 Scalable graph analysis tools for the connectomics community
Matelsky, J. K.; Johnson, E. C.; Wester, B.; Gray-Roncal, W. R.
10.1101/2022.06.01.494307 — neuroscience — Posted on 2022-06-02
3721 Connectome-based predictive modeling of cognitive reserve using task-based functional connectivity
Boyle, R.; Connaughton, M.; McGlinchey, E.; Knight, S. P.; De Looze, C.; Carey, D.; Stern, Y.; Robertson, I. H.; Kenny, R. A.; Whelan, R.
10.1101/2022.06.01.494342 — neuroscience — Posted on 2022-06-02
3722 Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in mice
Ross, R. A.; Kim, A.; Das, P.; Li, Y.; Choi, Y. K.; Thompson, A. T.; Douglas, E.; Subramanian, S.; Ramos, K.; Callahan, K.; Bolshakov, V. Y.; Ressler, K. J.
10.1101/2022.06.01.494383 — neuroscience — Posted on 2022-06-02
3727 Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes
Peruzzi, J. A.; Steinkuehler, J.; Vu, T. Q.; Gunnels, T. F.; Lu, P.; Baker, D.; Kamat, N. P.
10.1101/2022.06.01.494374 — synthetic biology — Posted on 2022-06-02
3729 Of Problems and Opportunities - How to Treat and How to not Treat Crystallographic Fragment-Screening Data
Weiss, M. S.; Wollenhaupt, J.; Correy, G. J.; Fraser, J. S.; Heine, A.; Klebe, G.; Krojer, T.; Thunnissen, M.; Pearce, N. M.
10.1101/2022.06.01.492756 — scientific communication and education — Posted on 2022-06-02
3731 Variable Number Tandem Repeats (VNTRs) as modifiers of breast cancer risk in carriers of BRCA1 185delAG
Ding, Y. C.; Adamson, A. W.; Bakhtiari, M.; Patrick, C.; Park, J.; Laitman, Y.; Weitzel, J. N.; Bafna, V.; Friedman, E.; Neuhausen, S. L.
10.1101/2022.06.01.494371 — cancer biology — Posted on 2022-06-02
3736 OmicSelector: automatic feature selection and deep learning modeling for omic experiments.
Stawiski, K.; Kaszkowiak, M.; Mikulski, D.; Hogendorf, P.; Durczynski, A.; Strzelczyk, J.; Chowdhury, D.; Fendler, W.
10.1101/2022.06.01.494299 — bioinformatics — Posted on 2022-06-02
3740 Opto-MASS: a high-throughput engineering platform for genetically encoded fluorescentsensors enabling all optical in vivo detection of monoamines and neuropeptides
Rappleye, M.; Gordon-Fennel, A.; Castro, D. C.; Matarasso, A. K.; Zamorano, C. A.; Wait, S. J.; Lee, J. D.; Siebart, J. D.; Suko, A.; Smith, N. C.; Muster, J.; Matreyek, K. A.; Fowler, D. M.; Stuber, G. D.; Bruchas, M. R.; Berndt, A.
10.1101/2022.06.01.494241 — bioengineering — Posted on 2022-06-02
3741 Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Bothe, S.; Haenzelmann, P.; Boehler, S.; Kehrein, J.; Wiedemann, C.; Hellmich, U.; Brenk, R.; Schindelin, H.; Sotriffer, C.
10.1101/2022.06.01.494394 — biochemistry — Posted on 2022-06-02
3742 Inherent evolutionary unpredictability in cancer model system
Chattopadhyay, S.; Karlsson, J.; Manas, A.; Kanzaki, R.; Fredlund, E.; Murphy, A. J.; Morton, C. L.; Andersson, N.; Hansson, K.; Radke, K.; Davidoff, A. M.; Mohlin, S.; Pietras, K.; Bexell, D.; Gisselsson, D.
10.1101/2022.06.01.494285 — evolutionary biology — Posted on 2022-06-02
3747 Crosshair, semi-automated targeting for electron microscopy with a motorised ultramicrotome
Meechan, K.; Guan, W.; Riedinger, A.; Stankova, V.; Yoshimura, A.; Pipitone, R.; Milberger, A.; Schaar, H.; Romero-Brey, I.; Templin, R.; Peddie, C. J.; Schieber, N. L.; Jones, M. L.; Collinson, L.; Schwab, Y.
10.1101/2022.06.02.491151 — cell biology — Posted on 2022-06-02
3749 Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT
Benedyk, T. H.; Connor, V.; Caroe, E. R.; Shamin, M.; Svergun, D. I.; Deane, J. E.; Jeffries, C. M.; Crump, C. M.; Graham, S. C.
10.1101/2022.06.01.494398 — microbiology — Posted on 2022-06-02
3752 Language exposure and brain myelination in early development
Fibla, L.; Forbes, S. H.; McCarthy, J.; Mee, K.; Magnotta, V. A.; Deoni, S.; Cameron, D.; Spencer, J. P.
10.1101/2022.05.31.493945 — neuroscience — Posted on 2022-06-02
3755 Maternal obesity programs hypothalamic miR-505-5p expression in mouse offspring and impacts hypothalamic fatty acid sensing
Furigo, I. C.; Pantaleao, L. C.; de Almeida-Faria, J.; Kentistou, K. A.; Carreira, M. V.; Ong, K. K.; Perry, J. R.; Donato, J.; Dearden, L.; Ozanne, S. E.
10.1101/2022.06.01.494310 — neuroscience — Posted on 2022-06-02
3756 Large-scale brain correlates of sweet versus cocaine reward in rats
Lenoir, M.; Navailles, S.; Vandaele, Y.; Vouillac-Mendoza, C.; Guillem, K.; Ahmed, S. H.
10.1101/2022.06.01.494287 — neuroscience — Posted on 2022-06-02
3758 Biocompatible polymeric microparticles serve as novel and reliable vehicles for exogenous hormone manipulations in passerines
Mahr, K.; Anzengruber, M.; Hellerschmid, A.; Slezaceck, J.; Hoi, H.; Subbiahdoss, G.; Gabor, F.; Lendvai, A. Z.
10.1101/2022.06.01.494300 — physiology — Posted on 2022-06-02
3759 The kinetic landscape of human transcription factors
Mamrak, N. E.; Alerasool, N.; Griffith, D.; Holehouse, A. S.; Taipale, M.; Lionnet, T.
10.1101/2022.06.01.494187 — biophysics — Posted on 2022-06-02
3761 An ensemble method for designing phage-based therapy against bacterial infections
Aggarwal, S.; Dhall, A.; Patiyal, S.; Choudhury, S.; Arora, A.; Raghava, G. P. S.
10.1101/2022.06.01.494305 — bioinformatics — Posted on 2022-06-02
3762 The complexity of keratocyte migration in salmon explant cultures: initial results and future prospects
Opstad, I. S.; Wolfson, D. L.; Ahluwalia, B. S.; Agarwal, K.; Seternes, T.; Dalmo, R. A.
10.1101/2022.06.01.494312 — cell biology — Posted on 2022-06-02
3765 Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Park, Y.-J.; Pinto, D.; Walls, A. C.; Liu, Z.; De Marco, A.; Benigni, F.; Zatta, F.; Silacci-Fregni, C.; Bassi, J.; Sprouse, K. R.; Addetia, A.; Bowen, J. E.; Stewart, C.; Giurdanella, M.; Saliba, C.; Guarino, B.; Schmid, M.; Franko, N.; Logue, J.; Dang, H. V.; di Iulio, J.; Rivera, W.; Schnell, G.; Lempp, F.; Janer, J.; Abdelnabi, R.; Maes, P.; Ferrari, P.; Ceschi, A.; Giannini, O.; de Melo, G.; Kergoat, L.; Bourhy, H.; Neyts, J.; Soriagha, L.; Purcell, L.; Snell, G.; Whelan, S.; Lanzavecchia, A.; Virgin, H.; Piccoli, L.; Chu, H.; Pizzuto, M. S.; Corti, D.; Veesler, D.
10.1101/2022.05.08.491108 — immunology — Posted on 2022-06-02
3768 Melatonin suppression does not automatically alter sleepiness, vigilance, sensory processing, or sleep
Blume, C.; Niedernhuber, M.; Spitschan, M.; Slawik, H. C.; Meyer, M. P.; Bekinschtein, T.; Cajochen, C.
10.1101/2022.04.12.488023 — neuroscience — Posted on 2022-06-02
3771 Reconstructing human Brown Fat developmental trajectory in vitro
Rao, J.; chal, J.; Marchiano, F.; Wang, C.-H.; Al Tanoury, Z.; Gapon, S.; Djeffal, Y.; Mayeuf-Louchart, A.; Glass, I.; Sefton, E.; Habermann, B.; Kardon, G.; Watt, f.; Tseng, Y.-H.; Pourquie, O.
10.1101/2022.06.01.494355 — developmental biology — Posted on 2022-06-02
3772 Genomic and transcriptomic landscape of advanced renal cell cancer to individualize treatment strategy
de Joode, K.; van de Geer, W. S.; van Leenders, G. J. L. H.; Hamberg, P.; Westgeest, H. M.; Beeker, A.; Oosting, S. F.; van Rooijen, J. M.; Beerepoot, L. V.; Labots, M.; Mathijssen, R. H. J.; Lolkema, M. P.; Cuppen, E.; Sleijfer, S.; van de Werken, H. J. G.; van der Veldt, A. A. M.
10.1101/2022.04.22.488773 — cancer biology — Posted on 2022-06-02
3775 Conserved degronome features governing quality control-associated proteolysis
Mashahreh, B.; Armony, S.; Johansson, K. E.; Chappleboim, A.; Friedman, N.; Gardner, R.; Hartmann-Petersen, R.; Lindorff-Larsen, K.; Ravid, T.
10.1101/2022.04.06.487275 — cell biology — Posted on 2022-06-02
3776 Genomic contributions to infant and toddler vocabulary scores: Implications for association with health-, cognition- and behaviour-related outcomes
Verhoef, E.; Allegrini, A. G.; Jansen, P. R.; Lange, K.; Wang, C. A.; Morgan, A. T.; Ahluwalia, T. S.; Symeonides, C.; EAGLE working group, ; Bisgaard, H.; Eising, E.; Franken, M.-C.; Hypponen, E.; Mansell, T.; Olislagers, M.; Omerovic, E.; Rimfeld, K.; Schlag, F.; Selzam, S.; Shapland, C. Y.; Tiemeier, H.; Whitehouse, A. J. O.; Saffery, R.; Bonnelykke, K.; Reilly, S.; Pennell, C. E.; Wake, M.; Cecil, C. A. M.; Plomin, R.; Fisher, S. E.; St. Pourcain, B.
10.1101/2022.06.01.494306 — genomics — Posted on 2022-06-01
3778 Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample
Moses, M.; Tiego, J.; Demontis, D.; Walters, B.; Stefansson, H.; Stefansson, K.; Borglum, A.; Arnatkeviciute, A.; Bellgrove, M. A.
10.1101/2022.05.31.494251 — neuroscience — Posted on 2022-06-02
3779 Development of neonatal brain functional centrality and alterations associated with preterm birth
Fenn-Moltu, S.; Fitzgibbon, S. P.; Ciarrusta, J.; Eyre, M.; Cordero-Grande, L.; Chew, A.; Falconer, S.; Gale-Grant, O.; Harper, N.; Dimitrova, R.; Vecchiato, K.; Fenchel, D.; Javed, A.; Earl, M.; Price, A.; Hughes, E.; Duff, E.; O'Muircheartaigh, J.; Nosarti, C.; Arichi, T.; Rueckert, D.; Counsell, S.; Hajnal, J. V.; Edwards, A. D.; McAlonan, G.; Batalle, D.
10.1101/2022.06.01.494304 — neuroscience — Posted on 2022-06-02
3780 Protein arginine and lysine methylation in Trypanosoma cruzi
de Almeida, R. F.; Lucena, A. C. R.; Batista, M.; Marchini, F. K.; de Godoy, L. M. F.
10.1101/2022.03.12.484072 — genomics — Posted on 2022-06-01
3782 Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
Sessions, D. T.; Kim, K.-B.; Kashatus, J. A.; Churchill, N.; Park, K.-S.; Mayo, M. W.; Sesaki, H.; Kashatus, D. F.
10.1101/2022.06.01.494337 — cell biology — Posted on 2022-06-01
3783 A neural circuit for wind-guided olfactory navigation
Matheson, A. M. M.; Lanz, A. J.; Medina, A. M.; Licata, A. M.; Currier, T. A.; Syed, M. H.; Nagel, K. I.
10.1101/2021.04.21.440842 — neuroscience — Posted on 2022-06-01
3784 Direct linkage detection with multimodal IVA fusion reveals markers of age, sex, cognition, and schizophrenia in large neuroimaging studies
Silva, R. F.; Damaraju, E.; Li, X.; Kochonov, P.; Belger, A.; Ford, J. M.; McEwen, S.; Mathalon, D. H.; Mueller, B. A.; Potkin, S. G.; Preda, A.; Turner, J. A.; van Erp, T. G. M.; Adali, T.; Calhoun, V. D.
10.1101/2021.12.13.472507 — neuroscience — Posted on 2022-06-01
3785 The landscape of metabolic brain alterations in Alzheimer's disease
Batra, R.; Arnold, M.; Woerheide, M.; Allen, M.; Wang, X.; Blach, C.; Levey, A. I.; Seyfried, N.; Ertekin-Taner, N.; Bennett, D. A.; Kastenmüller, G.; Kaddurah-Daouk, R.; Krumsiek, J.
10.1101/2021.11.15.468698 — neuroscience — Posted on 2022-06-01
3786 CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
Leng, K.; Rose, I. V. L.; Kim, H.; Xia, W.; Romero-Fernandez, W.; Rooney, B.; Koontz, M.; Li, E.; Ao, Y.; Krawczyk, M.; TCW, J.; Goate, A.; Zhang, Y.; Ullian, E. M.; Sofroniew, M. V.; Fancy, S. P. J.; Schrag, M. S.; Lippmann, E. S.; Kampmann, M.; Wang, S.
10.1101/2021.08.23.457400 — neuroscience — Posted on 2022-06-01
3789 Early Detection of Tau Pathology
Parekh, P. A.; Badachhape, A.; Mu, Q.; Bhavane, R.; Srivastava, M.; Bhandari, P.; Devkota, L.; Eriksen, J.; Tanifum, E.; Ghaghada, K.; Annapragada, A.
10.1101/2021.05.14.444233 — neuroscience — Posted on 2022-06-01
3790 An active RNA transport mechanism into plant vacuoles
Floyd, B. E.; Kazibwe, Z.; Morriss, S. C.; Mugume, Y.; Liu, A.-Y.; Ridout, V.; Luo, X.; MacIntosh, G. C.; Bassham, D. C.
10.1101/2021.07.28.454214 — plant biology — Posted on 2022-06-01
3791 A remodeled RNA polymerase II complex catalyzing viroid RNA-templated transcription
Dissanayaka Mudiyanselage, S. D.; Ma, J.; Pechan, T.; Pechanove, O.; Liu, B.; Wang, Y.
10.1101/2022.05.31.494195 — plant biology — Posted on 2022-06-01
3794 Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
Koppes, E. A.; Johnson, M. A.; Moresco, J. J.; Luppi, P.; Lewis, D. W.; Stolz, D. B.; Diedrich, J. K.; Yates, J. R.; Wek, R. C.; Watkins, S. C.; Gollin, S. M.; Park, H. J.; Drain, P.; Nicholls, R. D.
10.1101/2021.12.16.473032 — genetics — Posted on 2022-06-01
3797 Glycoproteomics Identifies Plexin-B3 as Targetable Cell Surface Protein Required for Growth and Invasion of Triple Negative Breast Cancer Cells
Kuhlmann, L.; Govindarajan, M.; Mejia-Guerrero, S.; Ignatchenko, V.; Liu, L. Y.; Grunwald, B. T.; Cruickshank, J.; Berman, H.; Khokha, R.; Kislinger, T.
10.1101/2022.06.01.494315 — cancer biology — Posted on 2022-06-01
3802 Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs
Han, S. K.; McNulty, M. T.; Benway, C. J.; Wen, P.; Greenberg, A.; Onuchic-Whitford, A. C.; NEPTUNE, ; Wilson, P. C.; Humphreys, B. D.; Wen, X.; Han, Z.; Lee, D.; Sampson, M. G.
10.1101/2022.06.01.494352 — genomics — Posted on 2022-06-01
3803 Mapping-by-sequencing reveals genomic regions associated with seed quality parameters in Brassica napus
Schilbert, H. M.; Pucker, B.; Ries, D.; Viehöver, P.; Micic, Z.; Dreyer, F.; Beckmann, K.; Wittkop, B.; Weisshaar, B.; Holtgräwe, D.
10.1101/2022.06.01.494149 — genomics — Posted on 2022-06-01
3806 Spatiotemporal dynamics of zygotic genome activation in basal chordates revealed by interspecific hybrids
Wei, J.; Zhang, W.; Leng, L.; Jiang, A.; Li, Y.; Ge, Y.; Zhang, Q.; Zhang, L.; Yu, H.; Chen, K.; Dong, B.
10.1101/2022.06.01.494324 — developmental biology — Posted on 2022-06-01
3807 ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid cells
Mabuchi, A.; Hata, S.; Genova, M.; Tei, C.; Ito, K. K.; Hirota, M.; Komori, T.; Fukuyama, M.; Chinen, T.; Toyoda, A.; Kitagawa, D.
10.1101/2022.06.01.494308 — cell biology — Posted on 2022-06-01
3808 Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma
De Martino, M.; Daviaud, C.; Minns, H. E.; Attarwala, N.; Chen, Q.; Dephoure, N.; Gartrell, R. D.; Laiakis, E. C.; Vanpouille-Box, C.
10.1101/2022.06.01.494338 — cell biology — Posted on 2022-06-01
3812 The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans
Santiago-Tirado, F. H.; Hurtaux, T.; Geddes-McAlister, J.; Nguyen, D.; Helms, V.; Doering, T. L.; Romisch, K.
10.1101/2022.06.01.494298 — microbiology — Posted on 2022-06-01
3814 Genetic determinants of host tropism in Klebsiella phages
Beamud, B.; Garcia-Gonzalez, N.; Gomez-Ortega, M.; Gonzalez-Candelas, F.; Domingo-Calap, P.; Sanjuan, R.
10.1101/2022.06.01.494021 — microbiology — Posted on 2022-06-01
3815 A transcriptome atlas of leg muscles from healthy human volunteers reveals molecular and cellular signatures associated with muscle location
Abbass-Daloii, T.; el Abdellaoui, S.; Voortman, L. M.; Veeger, T.; Cats, D.; Mei, L.; Meuffels, D.; van Arkel, E.; Bram 't Hoen, P.; Kan, H.; Raz, V.
10.1101/2022.06.01.494335 — neuroscience — Posted on 2022-06-01
3816 RPTPγ is a redox-regulated suppressor of promigratory EGFR signaling
Joshi, M. S.; Stanoev, A.; Soetje, B.; Huebinger, J.; Zorina, V.; Rossmannek, L.; Michel, K.; Bastiaens, P. I. H.
10.1101/2022.06.01.494340 — systems biology — Posted on 2022-06-01
3817 A high confidence Physcomitrium patens plasmodesmata proteome by iterative scoring and validation reveals diversification of cell wall proteins during evolution
Gombos, S.; Miras, M. M.; Howe, V.; Xi, L.; Pottier, M.; Jasemi, N. S. K.; Schladt, M.; Ejike, J. O.; Neumann, U.; Hansch, S.; Kutting, F.; Zhang, Z.; Dickmanns, M.; Xu, P.; Stefan, T.; Baumeister, W.; Frommer, W. B.; Simon, R.; Schulze, W.
10.1101/2022.06.01.492581 — plant biology — Posted on 2022-06-01
3818 Claudin-4, a core component of the tight-junctional complex along the collecting system, is induced in nephrotic syndrome
Olivier, V.; SASSI, A.; Arnoux, G.; Chambrey, R.; Monnay, I.; Chassot, A.; Udwan, K.; Dizin, E.; Rutkowski, J. M.; Cheval, L.; Crambert, G.; Wagner, C. A.; Doucet, A.; Eladari, D.; Moll, S.; Feraille, E.; K Ramakrishnan, S.
10.1101/2022.06.01.494142 — physiology — Posted on 2022-06-01
3820 PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link
Lynch, J.; Wang, Y.; Li, Y.; Kavidia, K.; Fukuda, Y.; Ranjit, S.; Robinson, C. G.; Grace, C. R.; Xia, Y.; Peng, J.; Schuetz, J.
10.1101/2022.06.01.494336 — biochemistry — Posted on 2022-06-01
3823 Reconstructing human Brown Fat developmental trajectory in vitro
Pourquie, O.; Rao, J.; chal, J.; Marchiano, F.; Habermann, B.; Djeffal, Y.; Gapon, S.; Mayeuf-Louchart, A.; Watt, f.; Wang, C.-H.; Tseng, Y.-H.; Kardon, G.; Sefton, E.; Glass, I.; Al Tanoury, Z.
10.1101/2022.06.01.494355 — developmental biology — Posted on 2022-06-01
3824 IRES-independent, eIF2A/eIF2D-dependent translation of the enterovirus genome
Kim, H.; Aponte-Diaz, D.; Sotoudegan, M. S.; Arnold, J. J.; Cameron, C. E.
10.1101/2022.06.01.494276 — microbiology — Posted on 2022-06-01
3825 scMuffin: an R package for resolving solid tumor heterogeneity from single-cell expression data
Nale, V.; Di Nanni, N.; Chiodi, A.; Cifola, I.; Moscatelli, M.; Cocola, C.; Gnocchi, M.; Piscitelli, E.; Reinbold, R.; Zucchi, I.; Milanesi, L.; Mezzelani, A.; Pelucchi, P.; Mosca, E.
10.1101/2022.06.01.494129 — bioinformatics — Posted on 2022-06-01
3826 U1 snRNP-dependent suppression of miRNA biogenesis by alternative intronic polyadenylation in melanoma
Vorlova, S.; Blahetek, G.; Barbieri, R.; Kerstan, Y.; Rosa, A.; Bundalo, M.; Egg, M.; Butt, E.; Henke, E.; Doelken, L.; Houben, R.; Schilling, B.; Fischer, U.; Erhard, F.; Zernecke, A.
10.1101/2022.06.01.479622 — molecular biology — Posted on 2022-06-01
3827 Antiviral immune responses, cellular metabolism and adhesion are differentially modulated by SARS-CoV-2 ORF7a or ORF7b
Garcia-Garcia, T.; Fernandez-Rodriguez, R.; Redondo, N.; de Lucas-Rius, A.; Zaldivar-Lopez, S.; Dies Lopez-Ayllon, B.; Suarez-Cardenas, J. M.; Jimenez-Marin, A.; Montoya, M.; Garrido, J. J.
10.1101/2022.06.01.494101 — immunology — Posted on 2022-06-01
3833 Precise modelling and correction of a spectrum of β-thalassemic mutations in human erythroid cells by base editors
Prasad, K.; Devaraju, N.; George, A.; Ravi, N. S.; Mahalingam, G.; Rajendiran, V.; Panigrahi, L.; Venkatesan, V.; Lakhotiya, K.; Moorthy, Y.; Pai, A. A.; Nakamura, Y.; Kurita, R.; Balasubramanian, P.; Thangavel, S.; Velayudhan, S. R.; Marepally, S.; Srivastava, A.; Mohankumar, K. M.
10.1101/2022.06.01.494256 — genomics — Posted on 2022-06-01
3834 Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1
Nicoli, A.; Haag, F.; Marcinek, P.; He, R.; Kreissl, J.; Stein, J.; Marchetto, A.; Dunkel, A.; Hofmann, T.; Krautwurst, D.; Di Pizio, A.
10.1101/2022.06.01.494157 — molecular biology — Posted on 2022-06-01
3835 Anti-COVID-19 Activity of FDA Approved Drugs through RNA G-quadruplex Binding
Roy, S. S.; Sharma, S.; Rizvi, Z. A.; Sinha, D.; Gupta, D.; Rophina, M.; Sehgal, P.; Sadhu, S.; Tripathy, M. R.; Samal, S.; Maiti, S.; Scaria, V.; Sivasubbu, S.; Awasthi, A.; Harshan, K.; Jain, S.; Chowdhury, S.
10.1101/2022.05.31.493843 — molecular biology — Posted on 2022-06-01
3836 Acute expression of human APOBEC3B in mice causes lethality associated with RNA editing
Alonso de la Vega, A.; Temiz, N. A.; Tasakis, R.; Somogyi, K.; Reuveni, E.; Ben-David, U.; Stenzinger, A.; Poth, T.; Papavasiliou, F. N.; Harris, R. S.; Sotillo, R.
10.1101/2022.06.01.494353 — molecular biology — Posted on 2022-06-01
3837 SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis
McGrath, M.; Xue, Y.; Dillen, C.; Oldfield, L.; Assad-Garcia, N.; Zaveri, J.; Singh, N.; Baracco, L.; Taylor, L.; Vashee, S.; Frieman, M.
10.1101/2022.05.31.494211 — microbiology — Posted on 2022-06-01
3838 Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis
Gaertner, F.; Ishikawa-Ankerhold, H.; Stutte, S.; Fu, W.; Guo, C.; Weitz, J.; Dueck, A.; Zhang, Z.; van den Heuvel, D.; Fumagalli, V.; Lorenz, M.; von Baumgarten, L.; Stark, K.; Straub, T.; von Stillfried, S.; Boor, P.; Colonna, M.; Schulz, C.; Brocker, T.; Walzog, B.; Scheiermann, C.; Engelhardt, S.; Aird, W. C.; Petzold, T.; Sixt, M.; Rudelius, M.; Nerlov, C.; Iannacone, M.; Oostendorp, R. A. J.; Massberg, S.
10.1101/2022.05.31.494147 — immunology — Posted on 2022-06-01
3839 Brain Atlas for Glycoprotein Hormone Receptors at Single-Transcript Level
Ryu, V.; Gumerova, A. A.; Korkmaz, F.; Kang, S. S.; Katsel, P.; Miyashita, S.; Kannangara, H.; Cullen, L.; Chan, P.; Kuo, T.-C.; Padilla, A.; Zaidi, S.; Kim, S.-M.; New, M. I.; Rosen, C. J.; Goosens, K.; Frolinger, T.; Haroutunian, V.; Ye, K.; Lizneva, D.; Davies, T. F.; Yuen, T.; Zaidi, M.
10.1101/2022.06.01.494351 — neuroscience — Posted on 2022-06-01
3840 Non-rapid eye movement sleep determines resilience to social stress
Bush, B. J.; Donnay, C.; Andrews, E.-J. A.; Lewis-Sanders, D.; Gray, C.; Qiao, Z.; Brager, A. J.; Johnson, H.; Brewer, H.; Sood, S.; Saafir, T.; Benveniste, M.; Paul, K. N.; Ehlen, J. C.
10.1101/2022.06.01.494280 — neuroscience — Posted on 2022-06-01
3845 Mitochondrial function determines severity but not risk of amyotrophic lateral sclerosis
Harvey, C.; Weinreich, M.; Zhang, S.; Hop, P. J.; Zwamborn, R. A.; van Eijk, K. R.; Julian, T. H.; Moll, T.; Iacoangeli, A. R.; Al-Khleifat, A.; Quinn, J. P.; Pfaff, A. L.; Koks, S.; Poulton, J.; Battle, S. L.; Arking, D.; Snyder, M.; Project MinE ALS Sequencing Consortium, ; Veldink, J.; Kenna, K. P.; Shaw, P. J.; Cooper-Knock, J.
10.1101/2022.05.31.494229 — genetics — Posted on 2022-06-01
3851 Rapid Activation of Hematopoietic Stem Cells
Thapa, R.; Elfassy, E.; Olender, L.; Sharabi, O.; Gazit, R.
10.1101/2022.06.01.494258 — immunology — Posted on 2022-06-01
3852 Diffusion MR imaging in the corticospinal tract of idiopathic scoliosis
Franko, E.; Joly, O.; Coubard, O. A.; Baudrillard, J.-C.; Morin, C.; Rousie, D. L.
10.1101/2022.05.31.494193 — neuroscience — Posted on 2022-06-01
3854 Preparing glycomics data for robust statistical analysis with GlyCompareCT
Zhang, Y.; Sridevi, K.; Bao, B.; Chiang, W.-T.; Sorrentino, J. T.; Schinn, S.-M.; Kellman, B. P.; Lewis, N. E.
10.1101/2022.05.31.494178 — bioinformatics — Posted on 2022-06-01
3858 Incubation of palatable food craving is associated with brain-wide neuronal activation in mice
Madangopal, R.; Szelenyi, E.; Nguyen, J.; Brenner, M.; Drake, O.; Pham, D.; Shekara, A.; Jin, M.; Choong, J. J.; Heins, C.; Komer, L.; Weber, S.; Hope, B. T.; Shaham, Y.; Golden, S. A.
10.1101/2022.05.31.494210 — neuroscience — Posted on 2022-06-01
3859 The Value of Zero-filling in In Vivo MRS
Murali-Manohar, S.; Oeltzschner, G.; Barker, P. B.; Edden, R. A. E.
10.1101/2022.05.31.494144 — neuroscience — Posted on 2022-06-01
3862 Volumetric bioluminescence imaging of cellular dynamics with deep learning based light-field reconstruction
Morales-Curiel, L. F.; Castro--Olvera, G.; Gonzalez, A.; Lin, L.-C.; El-Quessny, M.; Porta-de-la-Riva, M.; Severino, J.; Battle, L.; Ramallo, D.; Ruprecht, V.; Loza-Alvarez, P.; Krieg, M.
10.1101/2022.05.31.494105 — bioengineering — Posted on 2022-06-01
3866 The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension
Gorelova, A.; Berman, M.; Sharifi-Sanjani, M.; Pulgarin Rocha, A.; Alsuraimi, A.; Riva, P.; Negi, V.; Bertero, T.; Goncharov, D.; Kudryashova, T.; Dosunmu-Ogunbi, A.; Rajaratnam, A.; Harvey, L.; Nouraie, M.; Baust, J.; Bachman, T.; Sembrat, J.; Vargas, S. O.; Waxman, A. B.; Saggar, R.; Kumar, R.; Graham, B.; Straub, A. C.; Goncharova, E. A.; Mora, A.; Chan, S. Y.; Al Ghouleh, I.
10.1101/2022.05.31.494181 — cell biology — Posted on 2022-06-01
3868 A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods
Lista, M. J.; Ficarelli, M.; Wilson, H.; Kmiec, D.; Youle, R.; Wanford, J.; Winstone, H.; Odendall, C.; Taylor, I. A.; Neil, S. J.; Swanson, C. M.
10.1101/2022.05.31.494266 — microbiology — Posted on 2022-06-01
3870 Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Park, Y.-J.; Pinto, D.; Walls, A. C.; Liu, Z.; De Marco, A.; Benigni, F.; Zatta, F.; Silacci-Fregni, C.; Bassi, J.; Sprouse, K. R.; Addetia, A.; Bowen, J. E.; Stewart, C.; Giurdanella, M.; Saliba, C.; Guarino, B.; Schmid, M.; Franko, N.; Logue, J.; Dang, H. V.; di Iulio, J.; Rivera, W.; Schnell, G.; Lempp, F.; Janer, J.; Abdelnabi, R.; Maes, P.; Ferrari, P.; Ceschi, A.; Giannini, O.; de Melo, G.; Kergoat, L.; Bourhy, H.; Neyts, J.; Soriagha, L.; Purcell, L.; Snell, G.; Whelan, S.; Lanzavecchia, A.; Virgin, H.; Piccoli, L.; Chu, H.; Pizzuto, M. S.; Corti, D.; Veesler, D.
10.1101/2022.05.08.491108 — immunology — Posted on 2022-06-01
3871 An in vivo biomarker to characterize ototoxic compounds and novel protective therapeutics
Bellairs, J. A.; Redila, V.; Wu, P.; Tong, L.; Webster, A.; Simon, J. A.; Rubel, E. W.; Raible, D. W.
10.1101/2022.05.31.493913 — neuroscience — Posted on 2022-06-01
3872 Assortative mixing in micro-architecturally annotated brain connectomes
Bazinet, V.; Hansen, J. Y.; Vos de Wael, R.; Bernhardt, B. C.; van den Heuvel, M. P.; Misic, B.
10.1101/2022.05.31.494070 — neuroscience — Posted on 2022-06-01
3873 A systems approach reveals species differences in hepatic stress response capacity
Russomanno, G.; Sison-Young, R.; Livoti, L. A.; Coghlan, H.; Jenkins, R. E.; Kunnen, S. J.; Fisher, C. P.; Reddyhoff, D.; Gardner, I.; Rehman, A. H.; Fenwick, S. W.; Jones, A. R.; Vermeil De Conchard, G.; Simonin, G.; Bertheux, H.; Weaver, R.; Liguori, M. J.; Clausznitzer, D.; Stevens, J. L.; Goldring, C. E.; Copple, I. M.
10.1101/2022.04.13.488145 — pharmacology and toxicology — Posted on 2022-06-01
3878 The immunogenomic landscape of cattle
Li, T.; Xia, T.; Wu, J.; Hong, H.; Sun, Z.; Wang, M.; Ding, F.; Wang, J.; Jiang, S.; Li, J.; Pan, J.; Yang, G.; Feng, J.; Dai, Y.; Zhang, X.; Zhou, T.; Li, T.
10.1101/2022.05.31.493931 — genomics — Posted on 2022-06-01
3879 Accelerating Minimap2 for accurate long read alignment on GPUs
Sadasivan, H.; Maric, M.; Dawson, E.; Iyer, V.; Israeli, J.; Narayanasamy, S.
10.1101/2022.03.09.483575 — genomics — Posted on 2022-06-01
3880 Achieving single nucleotide sensitivity in direct hybridization genome imaging
Wang, Y.; Cottle, W. T.; Wang, H.; Gavrilov, M.; Zou, R. S.; Bailey, S.; Ha, T.
10.1101/2022.05.31.494230 — genomics — Posted on 2022-06-01
3884 Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells
Ursin, R. L.; Dhakal, S.; Liu, H.; Jayaraman, S.; Park, H.-S.; Powell, H. R.; Sherer, M. L.; Littlefield, K. E.; Fink, A. L.; Ma, Z.; Mueller, A. L.; Chen, A. P.; Woldetsadik, Y. A.; Gearhart, P. J.; Larman, H. B.; Maul, R. W.; Pekosz, A.; Klein, S. L.
10.1101/2022.05.31.494237 — immunology — Posted on 2022-06-01
3887 Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.
Frias, E. S.; Hoseini, M.; Krukowski, K.; Paladini, M. S.; Grue, K.; Ureta, G.; Rienecker, K. D. A.; Walter, P.; Stryker, M. P.; Rosi, S.
10.1101/2022.05.31.494250 — neuroscience — Posted on 2022-06-01
3889 Highly-Automated, High-Throughput Replication of Yeast-based Logic Circuit Design Assessments
Goldman, R. P.; Moseley, R.; Roehner, N.; Cummins, B.; Vrana, J. D.; Clowers, K. J.; Bryce, D.; Beal, J.; DeHaven, M.; Nowak, J.; Higa, T.; Biggers, V.; Lee, P.; Hunt, J. P.; Haase, S. B.; Weston, M.; Zheng, G.; Deckard, A.; Gopaulakrishnan, S.; Stubbs, J. F.; Gaffney, N. I.; Vaughn, M. W.; Maheshri, N.; Mikhalev, E.; Bartley, B.; Markeloff, R.; Mitchell, T.; Nguyen, T.; Sumorok, D.; Walczak, N.; Myers, C.; Zundel, Z.; Hatch, B.; Scholz, J.; Colonna-Romano, J.
10.1101/2022.05.31.493627 — synthetic biology — Posted on 2022-06-01
3895 Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages
Li, X.; Pan, Y.; Yin, Q.; Wang, Z.; Shan, S.; Zhang, L.; Yu, J.; Qu, Y.; Sun, L.; Gui, F.; Lu, J.; Jing, Z.; Wu, W.; Huang, T.; Shi, X.; Li, J.; Li, X.; Li, D.; Wang, S.; Yang, M.; Zhang, L.; Duan, K.; Liang, M.; Yang, X.; Wang, X.
10.1101/2022.05.27.493682 — biochemistry — Posted on 2022-06-01
3897 Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's Disease related proteins
Oatman, S. R.; Reddy, J. S.; Quicksall, Z.; Carrasquillo, M. M.; Wang, X.; Liu, C.-C.; Yamazaki, Y.; Nguyen, T. T.; Malphrus, K.; Heckman, M.; Biswas, K.; Baker, M.; Martens, Y.; Zhao, N.; Rademakers, R.; DeTure, M.; Murray, M. E.; Kanekiyo, T.; Dickson, D. W.; Bu, G.; Allen, M.; Ertekin-Taner, N.
10.1101/2022.05.31.493731 — genetics — Posted on 2022-06-01
3898 Demes: a standard format for demographic models
Gower, G. R.; Ragsdale, A. P.; Gutenkunst, R. N.; Hartfield, M.; Noskova, E.; Struck, T. J.; Kelleher, J.; Thornton, K.
10.1101/2022.05.31.494112 — genetics — Posted on 2022-06-01
3901 Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites
Nelson, A. D.; Catalfio, A. M.; Gupta, J. M.; Min, L.; Caballero-Floran, R. N.; Dean, K. P.; Elvira, C. C.; Derderian, K. D.; Kyoung, H.; Sahagun, A.; Sanders, S. J.; Bender, K.; Jenkins, P. M.
10.1101/2022.05.31.494205 — neuroscience — Posted on 2022-06-01
3902 Preserved cognition in elderly with intact rhinal cortex
Sepehrband, F.; Lynch, K. M.; Gasperi, A. S.; Bienkowski, M.; Wang, X.; Chui, H. C.; Toga, A. W.
10.1101/2022.05.30.494074 — neuroscience — Posted on 2022-06-01
3905 Behavioral activity increases neuronal activity in the circadian clock of diurnal Arvicanthis ansorgei
Schoonderwoerd, R. A.; Caputo, R.; Ramkisoensing, A.; Janse, J. A. M.; van Diepen, H. C.; Raison, S.; Derks, N. A. V.; Sage-Ciocca, D.; Deboer, T.; Challet, E.; Meijer, J.
10.1101/2022.05.31.493966 — neuroscience — Posted on 2022-06-01
3906 Androgen receptor inhibition induces metabolic reprogramming and increased reliance on oxidative mitochondrial metabolism in prostate cancer
Crowell, P.; Giafaglione, J.; Jones, A.; Nunley, N.; Hashimoto, T.; Delcourt, A.; Petcherski, A.; Bernard, M.; Huang, R. R.; Low, J.-Y.; Matulionis, N.; Guan, X.; Navone, N.; Alumkal, J.; Haffner, M.; Ye, H.; Zoubeidi, A.; Christofk, H.; Shirihai, O. S.; Divakaruni, A. S.; Goldstein, A. S.
10.1101/2022.05.31.494200 — cancer biology — Posted on 2022-06-01
3910 Rewiring the Three-Carbon Metabolism Abrogates Multiple MAPK-Induced Cellular Dysfunctions During Metabolic Disorder
Dube, A. K.; Malenfant, N.; Ladonne, F.; Piano, A.; Mohammad, K.; Belanger, M.; Begin, F.; Lebel-Guay, F.; Titorenko, V. I.; Bourbonnais, Y.
10.1101/2021.06.30.450468 — cell biology — Posted on 2022-06-01
3911 Genome polarisation for detecting barriers to geneflow
Baird, S. J. E.; Petruzela, J.; Jaron, I.; Skrabanek, P.; Martinkova, N.
10.1101/2022.03.24.485605 — bioinformatics — Posted on 2022-06-01
3912 A novel nematode species from the Siberian permafrost shares adaptivemechanisms for cryptobiotic survival with C. elegans dauer larva
Shatilovich, A.; Gade, V. R.; Pippel, M.; Hoffmeyer, T. T.; Tchesunov, A. V.; Stevens, L.; Winkler, S.; Hughes, G. M.; Traikov, S.; Hiller, M.; Rivkina, E.; Schiffer, P. H.; Myers, E. W.; Kurzchalia, T. V.
10.1101/2022.01.28.478251 — genomics — Posted on 2022-06-01
3913 Comparison and critical assessment of single-cell Hi-C protocols
Gridina, M.; Taskina, A.; Lagunov, T.; Nurislamov, A.; Kulikova, T.; Krasikova, A.; Fishman, V.
10.1101/2022.05.08.491066 — genomics — Posted on 2022-06-01
3914 Mesodermal FGF and BMP govern the multi-step thyroid specification
Haerlingen, B.; Opitz, R.; Vandernoot, I.; Molinaro, A.; Shankar, M.; Gillotay, P.; Trubiroha, A.; Costagliola, S.
10.1101/2020.08.13.249540 — developmental biology — Posted on 2022-06-01
3915 The Normative Modeling Framework for Computational Psychiatry
Rutherford, S.; Kia, S. M.; Wolfers, T.; Fraza, C.; Zabihi, M.; Dinga, R.; Berthet, P.; Worker, A.; Verdi, S.; Ruhe, H. G.; Beckmann, C. F.; Marquand, A. F.
10.1101/2021.08.08.455583 — neuroscience — Posted on 2022-06-01
3916 A searchable image resource of Drosophila GAL4-driver expression patterns with single neuron resolution
Meissner, G. W.; Nern, A.; Dorman, Z.; DePasquale, G. M.; Forster, K.; Gibney, T.; Hausenfluck, J. H.; He, Y.; Iyer, N.; Jeter, J.; Johnson, L.; Johnston, R. M.; Lee, K.; Melton, B.; Yarbrough, B.; Zugates, C. T.; Clements, J.; Goina, C.; Otsuna, H.; Rokicki, K.; Svirskas, R. R.; Aso, Y.; Card, G. M.; Dickson, B. J.; Ehrhardt, E.; Goldammer, J.; Ito, M.; Kainmueller, D.; Korff, W.; Mais, L.; Minegishi, R.; Namiki, S.; Rubin, G. M.; Sterne, G. R.; Wolff, T.; Malkesman, O.; FlyLight Project Team,
10.1101/2020.05.29.080473 — neuroscience — Posted on 2022-06-01
3917 The human thalamus orchestrates neocortical oscillations during NREM sleep.
Schreiner, T.; Kaufmann, E.; Noachtar, S.; Mehrkens, J.-H.; Staudigl, T.
10.1101/2021.12.11.471766 — neuroscience — Posted on 2022-06-01
3920 A Parabrachial to Hypothalamic Neurocircuit Mediates Defensive Behavior
Wang, F.; Chen, Y.; Lin, Y.; Wang, X.; Li, K.; Han, Y.; Wu, J.; Shi, X.; Zhu, Z.; Long, C.; Hu, X.; Duan, S.; Gao, Z.
10.1101/2022.06.01.494296 — neuroscience — Posted on 2022-06-01
3921 Connectomic Analysis of Thalamus-driven Disinhibition in Cortical Layer 4
Hua, Y.; Loomba, S.; Pawlak, V.; Laserstein, P.; Boergens, K. M.; Kerr, J. N. D.; Helmstaedter, M.
10.1101/2022.06.01.494290 — neuroscience — Posted on 2022-06-01
3922 Decreasing Wapl dosage partially corrects transcriptome phenotypes in Nipbl-/+ embryonic mouse brain
Kean, C. M.; Tracy, C. J.; Mitra, A.; Van Winkle, M. T.; Gebert, C. M.; Noeker, J.; Calof, A.; Lander, A.; Kassis, J. A.; Pfeifer, K.
10.1101/2022.05.31.493745 — genetics — Posted on 2022-06-01
3923 Intracellular level of S. cerevisiae Rad51 is regulated via proteolysis in a SUMO- and Ubiquitin-dependent manner
Antoniuk-Majchrzak, J.; Długajczyk, A.; Enkhbaatar, T.; Kaminska, J.; Skoneczny, M.; Klionsky, D. J.; Skoneczna, A.
10.1101/2022.05.31.494133 — genetics — Posted on 2022-06-01
3926 Integrated workflow of down-scaled Smart-seq2 and absolute quantitative, single-cell digital PCR validates lack of representability of low-abundant transcripts
Lange, T.; Gross, T.; Jeney, A.; Scherzinger, J.; Sinkala, E.; Niemöller, C.; Zimmermann, S.; Koltay, P.; von Stetten, F.; Zengerle, R.; Jeney, C.
10.1101/2022.05.31.494164 — molecular biology — Posted on 2022-06-01
3927 Eukaryotic genomes from a global metagenomic dataset illuminate trophic modes and biogeography of ocean plankton
Alexander, H.; Hu, S. K.; Krinos, A. I.; Pachiadaki, M.; Tully, B. J.; Neely, C. J.; Reiter, T.
10.1101/2021.07.25.453713 — microbiology — Posted on 2022-06-01
3928 Lipid-mediated dimerization of membrane-anchored c-Src is driven by a cluster of lysine residues in the N-terminal SH4 domain.
Mohammad, I.-L.; Carvajal, J.; Fernandez, A.; Taules, M.; Fourgous, E.; Boublik, Y.; Le Roux, A.-L.; Roche, S.; Pons, M.
10.1101/2022.05.31.494233 — biophysics — Posted on 2022-06-01
3931 Unraveling Amazon tree community assembly using Maximum Information Entropy: a quantitative analysis of tropical forest ecology.
Pos, E.; de Souza Coelho, L.; de Andrade Lima Filho, D.; Salomco, R. P.; Amaral, I. L.; de Almeida Matos, F. D.; Castilho, C. V.; Phillips, O. L.; Guevara, J. E.; Carim, M. d. J. V.; Lopez, D. C.; Magnusson, W. E.; Wittmann, F.; Irume, M. V.; Martins, M. P.; Sabatier, D.; da Silva Guimarces, J. R.; Molino, J.-F.; Banki, O. S.; Fernandez Piedade, M. T.; Pitman, N. C. A.; Mendoza, A. M.; Ramos, J. F.; Hawes, J. E.; Almeida, E. J.; Barbosa, L. F.; Cavalheiro, L.; Vilela dos Santos, M. C.; Luize, B. G.; Moraes de Leco Novo, E. M.; Vargas, P. N.; Freire Silva, T. S.; Venticinque, E. M.; Manzatto, A
10.1101/2021.03.31.437717 — ecology — Posted on 2022-06-01
3934 Task-related, intrinsic oscillatory and aperiodic neural activity predict performance in naturalistic team-based training scenarios
Cross, Z. R.; Chatburn, A.; Melberzs, L.; Temby, P.; Pomeroy, D.; Schlesewsky, M.; Bornkessel-Schlesewsky, I.
10.1101/2021.08.29.456571 — neuroscience — Posted on 2022-06-01
3935 Mathematical Relationships between Spinal Motoneuron Properties
Caillet, A. H. D.; Phillips, A. T. M.; Farina, D.; Modenese, L.
10.1101/2021.08.05.455188 — neuroscience — Posted on 2022-06-01
3938 Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation
Wu, Y.; Qin, K.; Lopez, K. M.; Liu, J.; Nipper, M. H.; Deng, J. J.; Yin, X.; Ramjit, L. R.; Wang, P.; Ye, Z.
10.1101/2022.05.31.494216 — developmental biology — Posted on 2022-06-01
3939 Lipid flipping in the omega-3 fatty-acid transporter
Gonen, T.; Matthies, D.; Nguyen, C.; Lei, H.-T.; Lai, L. T. F.; Gallenito, M. J.
10.1101/2022.05.31.494244 — biophysics — Posted on 2022-06-01
3940 Computational Identification of Ligand-Receptor Pairs that Drive Human Astrocyte Development
Voss, A. J.; Lanjewar, S. N.; Sampson, M. M.; King, A.; Hill, E.; Sing, A.; Sojka, C.; Sloan, S. A.
10.1101/2022.05.31.491513 — neuroscience — Posted on 2022-06-01
3941 Molecular specification of cortico-brainstem versus corticospinal projection neurons in development
Kaiser, J.; Patel, P.; Dundar, F.; Perez-Tetuan, J.; Angira, N.; Sieger, E.; Sahni, V.
10.1101/2022.05.31.494253 — neuroscience — Posted on 2022-06-01