date is 2022-03
Select an archive month  
May 2025
April 2025
March 2025
February 2025
January 2025
December 2024
November 2024
October 2024
September 2024
August 2024
July 2024
June 2024
May 2024
April 2024
March 2024
February 2024
January 2024
December 2023
November 2023
October 2023
September 2023
August 2023
July 2023
June 2023
May 2023
April 2023
March 2023
February 2023
January 2023
December 2022
November 2022
October 2022
September 2022
August 2022
July 2022
June 2022
May 2022
April 2022
March 2022
February 2022
January 2022
December 2021
November 2021
October 2021
September 2021
August 2021
July 2021
June 2021
May 2021
April 2021
March 2021
February 2021
January 2021
December 2020
November 2020
October 2020
September 2020
August 2020
July 2020
June 2020
May 2020
April 2020
March 2020
February 2020
January 2020
December 2019
November 2019
October 2019
September 2019
August 2019
July 2019
June 2019
May 2019
April 2019
March 2019
February 2019
January 2019
December 2018
November 2018
October 2018
September 2018
August 2018
July 2018
June 2018
May 2018
April 2018
March 2018
February 2018
January 2018
December 2017
November 2017
October 2017
September 2017
August 2017
July 2017
June 2017
May 2017
April 2017
March 2017
February 2017
January 2017
December 2016
November 2016
October 2016
September 2016
August 2016
July 2016
June 2016
May 2016
April 2016
March 2016
February 2016
January 2016
December 2015
November 2015
October 2015
September 2015
August 2015
July 2015
June 2015
May 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013

Archive, 2022-03

2 Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases
Park, H.; Yu, Q.; Hundley, F. V.; Overmyer, K.; Serrano, L.; Paulo, J. A.; Paoli, J. C.; Swarup, S.; Coon, J.; Gygi, S.; Harper, W.
10.1101/2022.03.31.486371 — cell biology — Posted on 2022-03-31
3 AMPK-p38 axis converts human pluripotent stem cells to naïve state
Zhennan, Y.; Liu, Y.; Xu, H.; Yamane, J.; Hotta, A.; Fujibuchi, W.; Yamashita, J. K.
10.1101/2022.03.31.486536 — cell biology — Posted on 2022-03-31
5 A ROS-dependent mechanism to drive progression through S phase
Kirova, D. G.; Judasova, K.; Vorhauser, J.; Zerjatke, T.; Leung, J. K.; Glauche, I.; Mansfeld, J.
10.1101/2022.03.31.486607 — cell biology — Posted on 2022-03-31
7 Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer
Chaib, M.; Holt, J. R.; Sipe, L. M.; Bohm, M. S.; Joseph, S. C.; Yarbro, J.; Tanveer, U.; Hollingsworth, T. J.; Wei, Q.; Thomas, P.; Hayes, D. N.; Makowski, L.
10.1101/2022.03.31.486620 — immunology — Posted on 2022-03-31
8 Chemotherapy coupled to macrophage inhibition leads to enhanced T and B cell infiltration and durable triple negative breast cancer regression
Singh, S.; Lee, N.; Pedroza, D.; Bado, I.; Hamor, C.; Zhang, L.; Aguirre, S.; Hu, J.; Shen, Y.; Xu, Y.; Gao, Y.; Zhan, N.; Chen, S.-H.; Wan, Y.-W.; Liu, Z.; Chang, J.; Hollern, D.; Perou, C.; Zhang, X.; Rosen, J. M.
10.1101/2021.02.22.432300 — cancer biology — Posted on 2022-03-31
9 Oncogene-induced matrix reorganization controls CD8+ T cell function in the tumor microenvironment
Pruitt, H. C.; Fuller, A. M.; Song, H.; Liu, Y.; DeVine, A.; Katti, R. S.; Devalaraja, S.; Ciotti, G. E.; Gonzalez, M.; Williams, E. F.; Murazzi, I.; Skuli, N.; Hakonarson, H.; Weber, K.; Haldar, M.; Fraietta, J. A.; Gerecht, S.; Eisinger-Mathason, T. S. K.
10.1101/2022.03.31.486627 — cancer biology — Posted on 2022-03-31
15 Plastomes of Hyalomonas oviformis and Hyalogonium fusiforme evolved dissimilar architecture after loss of photosynthesis
DeShaw, A. E.; Figueroa Martinez, F.; Pröschold, T.; Lorenz, M.; Nedelcu, A. M.; Smith, D. R.; Reyes Prieto, A. A.
10.1101/2022.03.29.486296 — genomics — Posted on 2022-03-31
18 Impact of hydrostatic pressure on organic carbon cycling of the deep-sea microbiome
Amano, C.; Zhao, Z.; Sintes, E.; Reinthaler, T.; Stefanschitz, J.; Kisadur, M.; Utsumi, M.; Herndl, G. J.
10.1101/2022.03.31.486587 — ecology — Posted on 2022-03-31
20 Chemokine Receptor 1 and its associated immune pathway are downregulated in SF3B1MT blood and non-blood cancers
Dastpak, M.; Kim, H.; Paraggio, C. L.; Leonard, C. E.; Yin, S.; Chi, B.; Nassar, K. W.; Rowe, R. G.; Hou, Z.; Zhang, J.; Cohn, E. F.; Yang, N.; Marion, W.; Zhang, Y.; Daley, G. Q.; Reed, R.
10.1101/2022.03.31.485699 — molecular biology — Posted on 2022-03-31
21 Chaperone Requirements for De Novo Folding of Saccharomyces cerevisiae Septins
Hassell, D.; Denney, A.; Singer, E.; Benson, A.; Roth, A.; Ceglowski, J.; Steingesser, M.; McMurray, M.
10.1101/2022.03.31.486562 — molecular biology — Posted on 2022-03-31
22 Ultra-deep Sequencing of Hadza Hunter-Gatherers Recovers Vanishing Microbes
Merrill, B. D.; Carter, M. M.; Olm, M. R.; Dahan, D.; Tripathi, S.; Spencer, S. P.; Yu, F. B.; Jain, S.; Neff, N.; Jha, A. R.; Sonnenburg, E. D.; Sonnenburg, J. L.
10.1101/2022.03.30.486478 — microbiology — Posted on 2022-03-31
23 Magnetic Bead-Based Separation (MBS) of Pneumococcal Serotypes
York, A.; Huynh, E. T.; Mbodj, S.; Yolda-Carr, D.; Hislop, M.; Echlin, H.; Rosch, J. W.; Weinberger, D. M.; Wyllie, A. L.
10.1101/2021.06.06.447277 — microbiology — Posted on 2022-03-31
28 SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern
Alfi, O.; Hamdan, M.; Wald, O.; Yakirevitch, A.; Wandel, O.; Oiknine-Djian, E.; Gvili, B.; Knoller, H.; Rozendorn, N.; Golan Berman, H.; Adar, S.; Vorontsov, O.; Mandelboim, M.; Zakay-Rones, Z.; Oberbaum, M.; Panet, A.; Wolf, D.
10.1101/2022.03.31.486531 — microbiology — Posted on 2022-03-31
29 cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling
Ledvina, H. E.; Ye, Q.; Gu, Y.; Quan, Y.; Lau, R. K.; Zhou, H.; Corbett, K. D.; Whiteley, A. T.
10.1101/2022.03.31.486616 — microbiology — Posted on 2022-03-31
30 CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis
zhang, s.; Rautela, J.; Bediaga, N. G.; Kolesnik, T.; You, Y.; Dagley, L.; Bedo, J.; Wang, H.; Sun, L.; Sutherland, R.; Surgenor, E.; Iannarella, N.; Allan, R. S.; Souza-Fonseca-Guimaraes, F.; Xie, Y.; Wang, Q.; Zhang, Y.; Xu, Y.; Nutt, S. L.; Lew, A. M.; Huntington, N.; Nicholson, S. E.; Chopin, M.; Zhan, Y.
10.1101/2022.03.31.486495 — immunology — Posted on 2022-03-31
34 Prediction of infectivity of SARS-CoV2: Mathematical Model with Docking Simulation analysis between Spike Protein and ACE2
Takaoka, Y.; Sugano, A.; Morinaga, Y.; Ohta, M.; Miura, K.; Kataguchi, H.; Kumaoka, M.; Kimura, S.; Maniwa, Y.
10.1101/2022.03.30.486373 — bioinformatics — Posted on 2022-03-31
35 Context-aware deconvolution of cell-cell communication with Tensor-cell2cell
Armingol, E.; Baghdassarian, H.; Martino, C.; Perez-Lopez, A.; Aamodt, C.; Knight, R.; Lewis, N. E.
10.1101/2021.09.20.461129 — bioinformatics — Posted on 2022-03-31
36 Sensitive detection and structural characterisation of UV-induced cross-links in protein-RNA complexes using CLIR-MS
Sarnowski, C. P.; Knörlein, A.; de Vries, T.; Götze, M.; Beusch, I.; Aebersold, R.; Allain, F. H.- T.; Hall, J.; Leitner, A.
10.1101/2022.03.31.486537 — biochemistry — Posted on 2022-03-31
37 Helical remodeling augments 5-lipoxygenase activity
Gallegos, E. M.; Reed, T. D.; Mathes, F. A.; Guevara, N.; Neau, D.; Huang, W.; Newcomer, M. E.; Gilbert, N. C.
10.1101/2022.03.31.486615 — biochemistry — Posted on 2022-03-31
38 Protein Quaternary Structures in Solution are a Mixture of Multiple forms
Marciano, S.; Debabrata, D.; Listov, D.; Fleishman, S. J.; Sonn-Segev, A.; Mertens, H.; Busch, F.; Kim, Y.; Harvey, S. R.; Wysocki, V. H.; Schreiber, G.
10.1101/2022.03.30.486392 — biochemistry — Posted on 2022-03-31
39 Clinical mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2
Shak, C.; Vuolo, L.; Uddin, B.; Katoh, Y.; Brown, T.; Heesom, K.; Stevenson, N.; Nakayama, K.; Stephens, D.
10.1101/2022.03.31.486414 — cell biology — Posted on 2022-03-31
40 An in situ cut-and-paste genome editing platform mediated by CRISPR/Cas9 or Cas12a
Jiang, P.; Kemper, K. M.; Chang, K.-T.; Qian, C.; Li, Y.; Guan, L.; van Hasselt, P.; Caradonna, S.; Strich, R.
10.1101/2022.03.30.486486 — molecular biology — Posted on 2022-03-31
42 Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2Omicron variant BA.1 infection of human airway epithelial explant cultures
Volle, R.; Murer, L.; Petkidis, A.; Andriasyan, V.; Savi, A.; Bircher, C.; Meili, N.; Fisher, L.; Sequeira, D. P.; Mark, D. K.; Gonzalez, A. G.; Greber, U. F.
10.1101/2022.03.30.486461 — microbiology — Posted on 2022-03-31
43 Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19
Demarest, J. F.; Kienle, M.; Boytz, R.; Ayres, M.; Kim, E.; Chung, D.; Gandhi, V.; Davey, R. A.; Sykes, D. B.; Shohdy, N.; Pottage, J. C.; Kumar, V. S.
10.1101/2022.03.30.486499 — microbiology — Posted on 2022-03-31
44 Cross neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
Zou, J.; Kurhade, C.; Xia, H.; Liu, M.; Xie, X.; Ren, P.; Shi, P.-Y.
10.1101/2022.03.30.486409 — microbiology — Posted on 2022-03-31
45 Conformational flexibility, lipid binding, and regulatory domains in CelTOS
Kumar, H.; Jimah, J. R.; Ntumngia, F.; Misal, S. A.; Jones, S.; Fried, M.; Adams, J.; Schlesinger, P.; Tolia, N. H.
10.1101/2022.03.31.486524 — microbiology — Posted on 2022-03-31
46 Screening the Pathogen Box Compounds for Activity Against Plasmodium falciparum Sporozoite Motility
kanatani, S.; Elahi, R.; Kanchanabhogin, S.; Vartek, N.; Tripathi, A.; Prigge, S.; Sinnis, P.
10.1101/2022.03.30.486498 — microbiology — Posted on 2022-03-31
47 Fear extinction is regulated by long noncoding RNA activity at the synapse
Liau, W.-S.; Zhao, Q.; Bademosi, A.; Gormal, R.; Gong, H.; Marshall, P. R.; Periyakaruppiah, A.; Madugalle, S. U.; Zajackowski, E. L.; Leighton, L. J.; Ren, H.; Musgrove, M.; Davies, J.; Rauch, S.; He, C.; Dickinson, B.; Li, X.; Wei, W.; Meunier, F. A.; Fernandez Moya, S. M.; Kiebler, M. A.; Srinivasan, B.; Banerjee, S.; Clark, M.; Spitale, R. C.; Bredy, T. W.
10.1101/2022.03.30.486308 — neuroscience — Posted on 2022-03-31
48 Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila
Yamada, D.; Bushey, D.; Li, F.; Hibbard, K.; Sammons, M.; Funke, J.; Litwin-Kumar, A.; Hige, T.; Aso, Y.
10.1101/2022.03.30.486484 — neuroscience — Posted on 2022-03-31
57 Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus
Lutomska, L.; Miok, V.; Krahmer, N.; Gonzalez Garcia, I.; Gruber, T.; Le Thuc, O.; De Bernardis Murat, C.; Legutko, B.; Sterr, M.; Saher, G.; Lickert, H.; Muller, T. D.; Ussar, S.; Tschoep, M. H.; Lutter, D.; Garcia-Caceres, C.
10.1101/2022.03.30.486358 — neuroscience — Posted on 2022-03-31
62 CUT&Tag recovers up to half of ENCODE ChIP-seq peaks
Hu, D.; Abbasova, L.; Schilder, B. M.; Nott, A.; Skene, N. G.; Marzi, S. J.
10.1101/2022.03.30.486382 — genomics — Posted on 2022-03-31
64 A divide-and-conquer approach for genomic prediction in rubber tree using machine learning
Aono, A. H.; Francisco, F. R.; Souza, L. M.; Goncalves, P. d. S.; Scaloppi, E. J.; Guen, V. L.; Fritsche-Neto, R.; Gorjanc, G.; Quiles, M. G.; de Souza, A. P.
10.1101/2022.03.30.486381 — genetics — Posted on 2022-03-31
68 Identification and characterization of the T cell receptor (TCR) repertoire of the Cynomolgus macaque (Macaca Fascicularis)
Jaiswal, S.; Boyce, S.; Nyquist, S. K.; Jivanjee, T.; Ibrahim, S.; Bromley, J. D.; Gatter, G. J.; Gideon, H.; Patel, K.; Ganchua, S. K.; Berger, B.; Fortune, S. M.; Flynn, J.; Shalek, A. K.; Behar, S. M.
10.1101/2022.03.30.486315 — immunology — Posted on 2022-03-31
69 Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies
Lashuel, H. A.; Mahul-Mellier, A.-L.; Novello, S.; Hegde, R. N.; Jasiqi, Y.; Altay, F. M.; Donzelli, S.; DeGuire Sean, S. M.; Burai, R.; Magalhaes, P.; Chiki, A.; Ricci, J.; Boussouf Manel, M.; Sadek, A.; Stoops, E.; Iseli, C.; Guex, N.
10.1101/2022.03.30.486322 — neuroscience — Posted on 2022-03-31
71 Ageing critically transforms the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
Tejedor, A. R.; Sanchez-Burgos, I.; Estevez-Espinosa, M.; Garaizar, A.; Collepardo-Guevara, R.; Ramirez, J.; Espinosa, J. R.
10.1101/2022.03.30.486367 — biophysics — Posted on 2022-03-31
75 Identification and characterization of the WYL BrxR protein and its gene asseparable regulatory elements of a BREX phage restriction system
Luyten, Y.; Hausman, D.; Young, J. C.; Doyle, L. A.; Higashi, K. M.; Ubilla-Rodriguez, N. C.; Lambert, A. R.; Arroyo, C.; Forsberg, K. J.; Morgan, R. D.; Stoddard, B. L.; Kaiser, B. K.
10.1101/2021.12.19.473356 — molecular biology — Posted on 2022-03-31
76 Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity
Balle, C.; Armistead, B.; Kiravu, A.; Song, X.; Happel, A.-U.; Hoffmann, A.; Kanaan, S. B.; Nelson, J. L.; Gray, C.; Jaspan, H. B.; Harrington, W. E.
10.1101/2021.03.02.432825 — immunology — Posted on 2022-03-31
78 Robust retrieval of data stored in DNA by de Bruijn graph-based de novo strand assembly
Song, L.; Geng, F.; Gong, Z.; Chen, X.; Tang, J.; Gong, C.; Zhou, L.; Xia, R.; Han, M.; Xu, J.; Li, B.; Yuan, Y.
10.1101/2020.12.20.423642 — synthetic biology — Posted on 2022-03-31
84 Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers
Gineste, C.; Youhanna, S.; Vorrink, S. U.; Henriksson, S.; Hernandez, A.; Cheng, A. J.; Chaillou, T.; Buttgereit, A.; Schneidereit, D.; Friedrich, O.; Hultenby, K.; Bruton, J. D.; Ivarsson, N.; Sandblad, L.; Lauschke, V. M.; Westerblad, H.
10.1101/2021.03.29.437546 — cell biology — Posted on 2022-03-31
85 Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer
Ranti, D.; Wang, Y.-S.; Daza, J.; Bieber, C.; Salome, B.; Merritt, E.; Cavallo, J.-A.; Hegewisch-Solloa, E.; Mace, E. M.; Farkas, A. M.; Schroff, S.; Lee, B.; Tran, M.; Strandgaard, T.; Lindskrog, S. V.; Dyrskjot, L.; Qi, J.; Patel, M.; Geanon, D.; Kelly, G.; Dereal, R.; Lee, B.; Kim-Schulze, S.; Thin, T. H.; Garcia-Barros, M.; Beaumont, K. G.; Lee, Y.; LaRoche, D.; Sebra, R.; Brody, R.; Tocheva, A.; Hopkins, B.; Wiklund, P.; Galsky, M. D.; Bhardwaj, N.; Sfakianos, J. P.; Horowitz, A.
10.1101/2022.03.06.483198 — immunology — Posted on 2022-03-31
87 Structure-function conservation between the methyltransferases SETD3 and SETD6
Levy, D.; Elisha, L.; Abayev, E.; Cohn, O.; Shapira, G.; Shomron, N.; Feldman, M.
10.1101/2022.03.31.486554 — cell biology — Posted on 2022-03-31
90 Molecular Signatures and Cellular Diversity During Mouse Habenula Development
van de Haar, L. L.; Riga, D.; Boer, J.; Adolfs, Y.; Sieburgh, T. E.; van Dijk, R. E.; Watanabe, K. L.; van Kronenburg, N.; Broekhoven, M. H.; Posthuma, D.; Meye, F. J.; Basak, O.; Pasterkamp, R. J.
10.1101/2022.02.21.481251 — developmental biology — Posted on 2022-03-31
91 Microtubules self-repair in living cells
Gazzola, M.; Schaeffer, A.; Vianay, B.; Gaillard, J.; Blanchoin, L.; Thery, M.
10.1101/2022.03.31.486545 — cell biology — Posted on 2022-03-31
92 High fat diet initiates rapid adaptation of the intestine
Enriquez, J. R.; McCauley, H. A.; Zhang, K. X.; Sanchez, J. G.; Kalin, G. T.; Lang, R. A.; Wells, J. M.
10.1101/2022.03.31.486473 — cell biology — Posted on 2022-03-31
93 WWP2 osteoarthritis risk allele rs1052429-A confers risk by affecting cartilage matrix deposition via hypoxia associated genes
Tuerlings, M.; Janssen, G. M. C.; Boone, I.; van Hoolwerff, M.; Rodriguez Ruiz, A.; Houtman, E.; Suchiman, E. H. E. D.; van der Wal, R. J. P.; Nelissen, R. G. H. H.; Coutinho de Almeida, R.; van Veelen, P. A.; Ramos, Y. F. M.; Meulenbelt, I.
10.1101/2022.03.31.486523 — cell biology — Posted on 2022-03-31
96 Dynamic and Facilitated Binding of Topoisomerase Accelerates Topological Relaxation
Michieletto, D.; Fosado, Y. A. G.; Melas, E.; Baiesi, M.; Tubiana, L.; Orlandini, E.
10.1101/2021.08.28.458016 — biophysics — Posted on 2022-03-31
97 Contrastive learning on protein embeddings enlightens midnight zone
Heinzinger, M.; Littmann, M.; Sillitoe, I.; Bordin, N.; Orengo, C.; Rost, B.
10.1101/2021.11.14.468528 — bioinformatics — Posted on 2022-03-31
98 Plastomes of Hyalomonas oviformis and Hyalogonium fusiforme evolved dissimilar architecture after loss of photosynthesis
DeShaw, A. E.; Figueroa Martinez, F.; Pröschold, T.; Lorenz, M.; Nedelcu, A. M.; Smith, D. R.; Reyes Prieto, A. A.
10.1101/2022.03.29.486296 — genomics — Posted on 2022-03-31
99 Key roles for kinesin-13 and kinesin-20 in malaria parasite proliferation, polarity, and transmission revealed by genome-wide functional analysis
Zeeshan, M.; Rashpa, R.; Ferguson, D. J. P.; Abel, S.; Chahine, Z.; Brady, D.; vaughan, s.; Moores, C. A.; Le Roch, K. G.; Brochet, M.; Holder, A. A.; Tewari, R.
10.1101/2021.05.26.445751 — cell biology — Posted on 2022-03-31
100 Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes
YI, J.; MOREL, J.; COSTALLAT, M.; LEJAL, N.; DELMAS, B.; MUCHARDT, C.; Batsche, E.
10.1101/2022.03.30.486363 — molecular biology — Posted on 2022-03-31
102 Evaluation of the broth microdilution methodology for susceptibility testing of Mycobacterium tuberculosis in Peru
Puyen, Z. M.; Santos, E. D.; Vigo, A. N.; Coronel, J.; Alarcon, M. J.; Cotrina, V. V.; Moore, D.
10.1101/2022.03.29.486329 — microbiology — Posted on 2022-03-31
105 Ancestral origins are associated with SARS-CoV-2 susceptibility and protection in a Florida patient population
Shen, Y.; Khatri, B.; Rananaware, S.; Li, D.; Ostrov, D.; Jain, P.; Lessard, C.; Nguyen, C.
10.1101/2022.03.30.486345 — genetics — Posted on 2022-03-31
106 Slc9a6 mutation causes Purkinje cell loss and ataxia in the shaker rat
Figueroa, K. P.; Anderson, C. J.; Paul, S.; Dansithong, W.; Gandelman, M. M.; Scoles, D. R.; Pulst, S. M.
10.1101/2022.03.28.486143 — neuroscience — Posted on 2022-03-31
108 Long-range regulatory effects of Neandertal DNA in modern humans
Yermakovich, D.; Pankratov, V.; Vosa, U.; Yunusbayev, B.; Estonian Biobank Research Team, ; Dannemann, M.
10.1101/2021.10.20.464628 — genomics — Posted on 2022-03-31
109 Model selection in occupancy models: inference versus prediction
Stewart, P. S.; Stephens, P. A.; Hill, R.; Whittingham, M. J.; Dawson, W.
10.1101/2022.03.01.482466 — ecology — Posted on 2022-03-31
110 Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers
Gineste, C.; Youhanna, S.; Vorrink, S. U.; Henriksson, S.; Hernandez, A.; Cheng, A. J.; Chaillou, T.; Buttgereit, A.; Schneidereit, D.; Friedrich, O.; Hultenby, K.; Bruton, J. D.; Ivarsson, N.; Sandblad, L.; Lauschke, V. M.; Westerblad, H.
10.1101/2021.03.29.437546 — cell biology — Posted on 2022-03-31
111 The human placenta dictates the phenotype of decidual macrophages.
Vondra, S.; Hoebler, A.-L.; Lackner, A. I.; Raffetseder, J.; Mihalic, Z. N.; Saleh, L.; Kunihs, V.; Haslinger, P.; Wahrmann, M.; Husslein, H.; Oberle, R.; Kargl, J.; Haider, S.; Latos, P.; Knoefler, M.; Ernerudh, J.; Pollheimer, J.
10.1101/2022.03.29.486171 — immunology — Posted on 2022-03-31
112 Connectomic Analysis of the Drosophila Lateral Neuron Clock Cells Reveals the Synaptic Basis of Functional Pacemaker Classes.
Shafer, O. T.; Gutierrez, G. J.; Li, K.; Mildenhall, A.; Spira, D.; Marty, J.; Lazar, A. A.; Fernandez, M. d. l. P.
10.1101/2022.03.02.482743 — neuroscience — Posted on 2022-03-30
119 Behavioral and imaging analysis of Foxg1 heterozygous mice
Erickson, K. R.; Farmer, R.; Merritt, J. K.; Miletic Lanaghan, Z.; Does, M. D.; Ramadass, K.; Landman, B. A.; Cutting, L. E.; Neul, J. L.
10.1101/2022.03.29.486318 — neuroscience — Posted on 2022-03-30
120 Organ- and function-specific anatomical organization and bioelectronic modulation of the vagus nerve
Jayaprakash, N.; Toth, V.; Song, W.; Vardhan, A.; Levy, T.; Tomaio, J.; Qanud, K.; Mughrabi, I.; Saperstein, Y.; Chang, Y.-C.; Rob, M.; Daytz, A.; Abbas, A.; Ashville, J.; Vikatos, A.; Ahmed, U.; Nassrallah, Z.; Volpe, B.; Tracey, K. J.; Al-Abed, Y.; Datta-Chaudhuri, T.; Miller, L.; Barbe, M.; Lee, S.; Zanos, T.; Zanos, S.
10.1101/2022.03.07.483266 — neuroscience — Posted on 2022-03-30
121 Clathrin-mediated Endocytosis Facilitates Internalization of Magnaporthe oryzae Effectors into Rice Cells
Oliveira-Garcia, E.; Tamang, T. M.; Park, J.-E.; Dalby, M.; Martin-Urdiroz, M.; Rodriguez Herrero, C.; Hong Vu, A.; Park, S.; Talbot, N. J.; Valent, B.
10.1101/2021.12.28.474284 — plant biology — Posted on 2022-03-30
126 Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies
Ghose, S.; Ju, Y.; McDonough, E.; Ho, J.; Karunamurthy, A.; Chadwick, C.; Cho, S.; Rose, R.; Corwin, A.; Surrette, C.; Martinez, J. S.; Williams, E.; Sood, A.; Al-Kofahi, Y.; Falo, L. D.; Borner, K.; Ginty, F.
10.1101/2022.03.30.486438 — cell biology — Posted on 2022-03-30
127 Single-cell Transcriptomic Atlas of the Human Substantia Nigra in Parkinson's Disease
Wang, Q.; Wang, M.; Choi, I.; Ho, L.; Farrell, K.; Beaumont, K. G.; Sebra, R.; Crary, J. F.; Davis, D. A.; Sun, X.; Zhang, B.; Yue, Z.
10.1101/2022.03.25.485846 — neuroscience — Posted on 2022-03-30
129 Slc9a6 mutation causes Purkinje cell loss and ataxia in the shaker rat
Figueroa, K. P.; Anderson, C. J.; Paul, S.; Dansithong, W.; Gandelman, M. M.; Scoles, D. R.; Pulst, S. M.
10.1101/2022.03.28.486143 — neuroscience — Posted on 2022-03-30
133 3D Organic Bioelectronics for Monitoring In Vitro Stem Cell Cultures
Savva, A.; Saez, J.; Barberio, C.; Lu, Z.; Moysidou, C. M.; Kallitsis, K.; Withers, A.; Pitsalidis, C.; Owens, R. M.
10.1101/2022.03.30.486455 — bioengineering — Posted on 2022-03-30
134 Jumping out of trouble: Evidence for a cognitive map in guppies (Poecilia reticulata)
de Waele, H.; Vila Pouca, C.; van Boerdonk, D.; Luiten, E.; Leenheer, L. M.; Mitchell, D.; Vega-Trejo, R.; Kotrschal, A.
10.1101/2022.03.30.486400 — animal behavior and cognition — Posted on 2022-03-30
135 Glucocorticoids Mediate Transcriptome-wide Alternative Polyadenylation: Mechanisms and Functional Implications
Nguyen, T. T. L.; Liu, D.; Gao, H.; Ye, Z.; Lee, J.-H.; Wei, L.; Yu, J.; Zhang, L.; Wang, L.; Ordog, T.; Weinshilboum, R. M.
10.1101/2022.03.30.486468 — genomics — Posted on 2022-03-30
140 Longer metaphase and fewer chromosome segregation errors in modern human than Neandertal brain development
Mora-Bermudez, F.; Kanis, P.; Macak, D.; Peters, J.; Naumann, R.; Sarov, M.; Winkler, S.; Oegema, C. E.; Haffner, C.; Xing, L.; Wimberger, P.; Riesenberg, S.; Maricic, T.; Huttner, W. B.; Paabo, S.
10.1101/2022.03.30.486431 — neuroscience — Posted on 2022-03-30
141 Convergent impact of schizophrenia risk genes
Townsley, K. G.; Li, A.; Deans, P. M.; Fullard, J. F.; Yu, A.; Cartwright, S.; Zhang, W.; Wang, M.; Voloudakis, G.; Girdhar, K.; Stahl, E.; Akbarian, S.; Zhang, B.; Roussos, P.; Huckins, L. M.; Brennand, K. J.
10.1101/2022.03.29.486286 — neuroscience — Posted on 2022-03-30
145 Species Distribution Modeling of Aedes aegypti in Maricopa County, Arizona from 2014-2020
Holeva-Eklund, W. M.; Young, S. J.; Will, J.; Busser, N.; Townsend, J.; Hepp, C. M.
10.1101/2022.03.30.486464 — ecology — Posted on 2022-03-30
148 Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex
Passer, A. R.; Clancey, S. A.; Shea, T.; David-Palma, M.; Averette, A. F.; Boekhout, T.; Porcel, B. M.; Nowrousian, M.; Cuomo, C. A.; Sun, S.; Heitman, J.; Coelho, M. A.
10.1101/2022.03.30.486436 — microbiology — Posted on 2022-03-30
150 TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells
Hope, H. C.; Pickersgill, G.; Ginefra, P.; Vannini, N.; Cook, G. P.; Salmond, R. J.
10.1101/2022.03.30.486376 — immunology — Posted on 2022-03-30
152 A mini-TGA protein, lacking a functional DNA-binding domain, modulates gene expression through heterogeneous association with transcription factors
Tomaz, S.; Petek, M.; Lukan, T.; Pogacar, K.; Stare, K.; Teixeira Prates, E.; Jacobson, D. A.; Zrimec, J.; Bajc, G.; Butala, M.; Pompe Novak, M.; Dudley, Q. M.; Patron, N.; Taler-Vercic, A.; Usenik, A.; Turk, D.; Prat, S.; Coll, A.; Gruden, K.
10.1101/2022.03.30.486221 — plant biology — Posted on 2022-03-30
153 HTL/KAI2 signalling substitutes for light to control plant germination
Bunsick, M.; Xu, Z.; Pescetto, G.; Ly, G.; Hountalas, J.; Boyer, F.-D.; McErlean, C. S. P.; Scholes, J. D.; Lumba, S.
10.1101/2022.03.30.486460 — plant biology — Posted on 2022-03-30
155 PRMT5 is a therapeutic target in choroidal neovascularization
Muniyandi, A.; Martin, M.; Sun, M.; Sishtla, K.; Jensen, N. R.; Motolani, A.; Qi, X.; Boulton, M. E.; Prabhu, L.; Lu, T.; Corson, T. W.
10.1101/2022.03.30.486275 — pharmacology and toxicology — Posted on 2022-03-30
156 WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
Yan, Q.; Chen, J. F.-Y.; Cai, W.; Chen, H.; Wingrove, E.; Kurley, S.; Chan, L. H.; Zhang, M.; Arnal-Estape, A.; Zhao, M.; Balabaki, A.; Li, W.; Yu, X.; Dou, Y.; Liu, Y.; Jin, J.; Westbrook, T. F.; Nguyen, D.
10.1101/2022.03.30.486357 — cancer biology — Posted on 2022-03-30
157 Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
Pfeifer, K.; Wolfstetter, G.; Anthonydhason, V.; Masudi, T.; Arefin, B.; Bemark, M.; Mendoza-Garcia, P.; Palmer, R. H.
10.1101/2022.03.30.486387 — cancer biology — Posted on 2022-03-30
158 Intracellular Aβ42 aggregation leads to cellular thermogenesis
Chung, C. W.; Stephens, A. D.; Konno, T.; Ward, E.; Avezov, E.; Kaminski, C. F.; Hassanali, A.; Kaminski Schierle, G. S.
10.1101/2022.03.30.486355 — biophysics — Posted on 2022-03-30
163 Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins
Alonso-Lerma, B.; Jabalera, Y.; Morin, M.; Fernández, A.; Samperio, S.; Quesada, A.; Reifs, A.; Fernández-Peñalver, S.; Benítez, Y.; Soletto, L.; Gavira, J. A.; Diaz, A.; Vranken, W.; Kleinstiver, B. P.; Sanchez-Mejias, A.; Güell, M.; Mojica, F. J.; Moreno-Pelayo, M. A.; Montoliu, L.; Perez-Jimenez, R.
10.1101/2022.03.30.485982 — evolutionary biology — Posted on 2022-03-30
164 A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane
Guillen-Samander, A.; Wu, Y.; Pineda, S. S.; Garcia, F. J.; Eisen, J. N.; Leonzino, M.; Ugur, B.; Kellis, M.; Heiman, M.; De Camilli, P.
10.1101/2022.03.30.486314 — cell biology — Posted on 2022-03-30
166 Structural insights into crista junction formation by the Mic60-Mic19 complex
Bock-Bierbaum, T.; Funck, K.; Wollweber, F.; Lisicki, E.; Laborenz, J.; Noel, J. K.; Hessenberger, M.; von der Malsburg, A.; von der Malsburg, K.; Bernert, C.; Kunz, S.; Riedel, D.; Lilie, H.; Jakobs, S.; van der Laan, M.; Daumke, O.
10.1101/2022.03.30.486340 — cell biology — Posted on 2022-03-30
168 CRISPRi screen for enhancing heterologous α-amylase yield in Bacillus subtilis
Geissler, A. S.; Fehler, A. O.; Poulsen, L. D.; Gonzalez-Tortuero, E.; Kallehauge, T. B.; Alkan, F.; Anthon, C.; Seemann, S. E.; Rasmussen, M. D.; Breüner, A.; Hjort, C.; Vinther, J.; Gorodkin, J.
10.1101/2022.03.30.486407 — microbiology — Posted on 2022-03-30
170 SARS-CoV-2 accessory protein ORF8 decreases antibody-dependent cellular cytotoxicity
Beaudoin-Bussieres, G.; Arduini, A.; Bourassa, C.; Medjahed, H.; Gendron-Lepage, G.; Richard, J.; Pan, Q.; Wang, Z.; Liang, C.; Finzi, A.
10.1101/2022.03.30.486403 — immunology — Posted on 2022-03-30
171 Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-Stimulation
Starr, R.; Yang, X.; Aguilar, B.; Gumber, D.; Huard, S.; Wang, D.; Chang, W.-C.; Brito, A.; Chiu, V.; Ostberg, J. R.; Badie, B.; Forman, S. J.; Alizadeh, D.; Wang, L. D.; Brown, C. E.
10.1101/2022.03.30.486439 — immunology — Posted on 2022-03-30
172 Homozygous CADPS2 mutations cause neurodegenerative disease with Lewy bodies in parrots
Betancor, O. L.; Galosi, L.; Bonfili, L.; Eleuteri, A. M.; Cecarini, V.; Verin, R.; Dini, F.; Attili, A. R.; Biagini, L.; Robino, P.; Stella, M. C.; Yearout, D.; Dorschner, M. O.; Tsuang, D. W.; Rossi, G.; Zabetian, C. P.
10.1101/2022.03.30.483987 — neuroscience — Posted on 2022-03-30
175 The Structural and Biochemical Basis for FER Receptor Kinase Early Signaling Initiation in Arabidopsis
Kong, Y.; Chen, J.; Chen, H.; Shen, Y.; Wang, L.; Yan, Y.; Zhou, H.; Zheng, H.; Yu, F.; Ming, Z.
10.1101/2022.03.30.486374 — biochemistry — Posted on 2022-03-30
176 ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies
Low, J. S.; Jerak, J.; Tortorici, M. A.; McCallum, M.; Pinto, D.; Cassotta, A.; Foglierini, M.; Mele, F.; Abdelnabi, R.; Weynand, B.; Noack, J.; Montiel-Ruiz, M.; Bianchi, S.; Benigni, F.; Sprugasci, N.; Joshi, A.; Bowen, J. E.; Walls, A. C.; Jarrossay, D.; Morone, D.; Paparoditis, P.; Garzoni, C.; Ferrari, P.; Ceschi, A.; Neyts, J.; Purcell, L. A.; Snell, G.; Corti, D.; Lanzavecchia, A.; Veesler, D.; Sallusto, F.
10.1101/2022.03.30.486377 — immunology — Posted on 2022-03-30
181 Bacteriophages antagonize cGAS-like immunity in bacteria
Huiting, E.; Athukoralage, J.; Guan, J.; Silas, S.; Carion, H.; Bondy-Denomy, J.
10.1101/2022.03.30.486325 — microbiology — Posted on 2022-03-30
187 A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
Nardone, A.; Qui, X.; Feiglin, A.; Fu, X.; Spisak, S.; Feit, A.; Cohen Feit, G.; Xie, Y.; Font-Tello, A.; Guarducci, C.; Hermida Prado, F.; Syamala, S.; Lim, K.; Pun, M.; Cornwell, M.; Liu, W.; Ors, A.; Mohammed, H.; Brock, J. E.; Freedman, M. L.; Schiff, R.; Winer, E.; Long, H. W.; Metzger Filho, O.; Jeselsohn, R.
10.1101/2022.03.29.486217 — cancer biology — Posted on 2022-03-30
192 CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
Jalloh, S.; Olejnik, J.; Berrigan, J.; Nisa, A.; Suder, E. L.; Akiyama, H.; Lei, M.; Tyagi, S.; Bushkin, Y.; Muhlberger, E.; Gummuluru, S.
10.1101/2022.03.29.486190 — immunology — Posted on 2022-03-30
193 A comparison of intracranial volume estimation methods and their cross-sectional and longitudinal associations with age
Nerland, S.; Stokkan, T. S.; Jorgensen, K. N.; Wortinger, L. A.; Richard, G.; Beck, D.; van der Meer, D.; Westlye, L. T.; Andreassen, O. A.; Agartz, I.; Barth, C.
10.1101/2022.03.29.486254 — neuroscience — Posted on 2022-03-30
194 Multi-Layered Maps of Neuropil with Segmentation-Guided Contrastive Learning
Dorkenwald, S.; Li, P.; Januszewski, M.; Berger, D. R.; Maitin-Shepard, J.; Bodor, A. L.; Collman, F.; Schneider-Mizell, C. M.; Macarico da Costa, N.; Lichtman, J. W.; Jain, V.
10.1101/2022.03.29.486320 — neuroscience — Posted on 2022-03-30
197 A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage
Li, J.; Beiser, A.; Dey, N. B.; Takeda, S.; Saha, L. K.; Hirota, K.; Parker, L. L.; Carter, M.; Arrieta, M. I.; Sobol, R. W.
10.1101/2022.03.29.486126 — cancer biology — Posted on 2022-03-30
204 Phylogenomics Illuminates the Evolutionary History of Wild Silkmoths in Space and Time (Lepidoptera: Saturniidae)
Rougerie, R.; Cruaud, A.; Arnal, P.; Ballesteros-Mejia, L.; Condamine, F. L.; Decaens, T.; Elias, M.; Gey, D.; Hebert, P. D. N.; Kitching, I. J.; Lavergne, S.; Lopez-Vaamonde, C.; Murienne, J.; Cuenot, Y.; Nidelet, S.; Rasplus, J.-Y.
10.1101/2022.03.29.486224 — evolutionary biology — Posted on 2022-03-30
208 Transcriptomics, Regulatory Syntax, and Enhancer Identification in Heterogenous Populations of Mesoderm-Induced ESCs at Single-Cell Resolution
Khateb, M.; Perovanovic, J.; Ko, K. D.; Jiang, K.; Feng, X.; Acevedo-Luca, N.; Chal, J.; Ciuffoli, V.; Genzor, P.; Simone, J.; Haase, A. D.; Pourquie, O.; Dell'Orso, S.; Sartorelli, V.
10.1101/2022.03.29.486247 — developmental biology — Posted on 2022-03-30
209 Acinetobacter baumannii sampled from cattle and pigs represent novel clones
Mateo-Estrada, V.; Vali, L.; Hamouda, A.; Evans, B.; Castillo-Ramirez, S.
10.1101/2022.03.29.486289 — microbiology — Posted on 2022-03-30
216 Effects of taurine in mice and zebrafish behavioral assays with translational relevance to schizophrenia
Giongo, F. K.; Gallas-Lopes, M.; Benvenutti, R.; Sachett, A.; Bastos, L. M.; Rosa, A. R.; Herrmann, A. P.
10.1101/2022.03.29.486302 — pharmacology and toxicology — Posted on 2022-03-30
219 Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression in silico
Harris, B. T.; Rajasekaran, V.; Blackmur, J. P.; O'Callaghan, A.; Donnelly, K.; Timofeeva, M.; Vaughan-Shaw, P.; Din, F. V. N.; Dunlop, M. G.; Farrington, S. M.
10.1101/2022.03.29.485182 — bioinformatics — Posted on 2022-03-30
225 Sex differences in allometry for phenotypic traits indicate that females are not scaled males
Wilson, L. A. B.; Zajitschek, S. R. K.; Lagisz, M.; Mason, J.; Haselimashhadi, H.; Nakagawa, S.
10.1101/2022.03.29.486193 — evolutionary biology — Posted on 2022-03-30
227 Riparian forest restoration as sources of biodiversity and ecosystem functions in anthropogenic landscapes
Antonini, Y.; Beirao, M. V.; Costa, F. V.; Azevedo, C. S.; Wojakowski, M.; Kozovits, A.; Pires, M. R. S.; Sousa, H. C.; Messias, M. C. T. B.; Fujaco, M. A. G.; Leite, M. G. P.; Martins, J. P. V.; Monteiro, G. F.; Dirzo, R.
10.1101/2021.09.08.459375 — ecology — Posted on 2022-03-30
228 The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan
Meras, I.; Chotard, L.; Liontis, T.; Ratemi, Z.; Wiles, B.; Seo, J. H.; Van Raamsdonk, J. M.; Rocheleau, C. E.
10.1101/2021.06.04.447106 — cell biology — Posted on 2022-03-30
229 The human placenta dictates the phenotype of decidual macrophages.
Pollheimer, J.; Vondra, S.; Hoebler, A.-L.; Lackner, A. I.; Raffetseder, J.; Mihalic, Z. N.; Saleh, L.; Kunihs, V.; Haslinger, P.; Wahrmann, M.; Husslein, H.; Oberle, R.; Kargl, J.; Haider, S.; Latos, P.; Knoefler, M.; Ernerudh, J.
10.1101/2022.03.29.486171 — immunology — Posted on 2022-03-30
230 Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings
Boswell, K. L.; Watkins, T.; Cale, E. M.; Samsel, J.; Andrews, S. F.; Ambrozak, D. R.; Driscoll, J. I.; Messina, M. A.; Narpala, S.; Hopp, C. S.; Cagigi, A.; Casazza, J. P.; Yamamoto, T.; Zhou, T.; Schief, W. R.; Crompton, P. D.; Ledgerwood, J. E.; Connors, M.; Gama, L.; Kwong, P. D.; McDermott, A.; Mascola, J. R.; Koup, R. A.
10.1101/2022.03.29.485179 — immunology — Posted on 2022-03-30
231 Sleep spindles favor emotion regulation over memory consolidation of stressors in PTSD
Natraj, N.; Neylan, T. C.; Yack, L. M.; Metzler, T. J.; Woodward, S. H.; Hubachek, S. Q.; Dukes, C.; Udapa, N. S.; Mathalon, D. H.; Richards, A.
10.1101/2022.03.29.485950 — neuroscience — Posted on 2022-03-30
232 Focal Non-invasive Deep-brain Stimulation with Temporal Interference for the Suppression of Epileptic Biomarkers
Acerbo, E.; Jegou, A.; Luff, C.; Dzialecka, P.; Botzanowski, B.; Missey, F.; Ngom, I.; Lagarde, S.; Bartolomei, F.; Cassara, A.; Neufeld, E.; Jirsa, V.; Carron, R.; Grossman, N.; Williamson, A.
10.1101/2022.03.29.486252 — neuroscience — Posted on 2022-03-30
233 Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1
RAMIREZ-FRANCO, J.; DEBREUX, K.; EXTREMET, J.; MAULET, Y.; BELGHAZY, M.; VILLARD, C.; SANGIARDI, M.; YOUSSOUF, F.; EL FAR, L.; LEVEQUE, C.; DEBARNOT, C.; MARCHOT, P.; PANEVA, S.; DEBANNE, D.; RUSSIER, M.; SEAGAR, M.; IRANI, S. R.; EL FAR, O.
10.1101/2022.03.29.486232 — neuroscience — Posted on 2022-03-30
234 Pain as a Trigger for Epigenetic Modifications in Limbic Circuitry
Bryant, S.; Balouek-Thomert, J.-A.; Geiger, L. T.; Barker, D. J.; Pena, C. J.
10.1101/2022.03.29.486268 — neuroscience — Posted on 2022-03-30
237 The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro
McCloskey, M. C.; Kasap, P.; Ahmad, S. D.; Su, S.-H.; Chen, K.; Mansouri, M.; Ramesh, N.; Nishihara, H.; Belyaev, Y.; Abhyankar, V. V.; Begolo, S.; Singer, B. H.; Webb, K. F.; Kurabayashi, K.; Flax, J.; Waugh, R. E.; Engelhardt, B.; McGrath, J. L.
10.1101/2022.03.28.486095 — bioengineering — Posted on 2022-03-30
238 Structural insights into the regulation of acetylation-dependent genome condensation
Ibrahim, Z.; Wang, T.; Destaing, O.; Salvi, N.; Hoghoughi, N.; Rusu, A. D.; Gao, J.; Feletto, L.; Reynoird, N.; Schalch, T.; Zhao, Y.; Blackledge, M.; Khochbin, S.; Panne, D.
10.1101/2022.03.14.484228 — biochemistry — Posted on 2022-03-30
239 Development of a new 3D tracking system for multiple marmosets under free-moving conditions
Yurimoto, T.; Kumita, W.; Sato, K.; Kikuchi, R.; Shibuki, Y.; Hashimoto, R.; Kamioka, M.; Hayasegawa, Y.; Yamazaki, E.; Kurotaki, Y.; Goda, N.; Kitakami, J.; Fujita, T.; Inoue, T.; Sasaki, E.
10.1101/2022.03.29.486138 — animal behavior and cognition — Posted on 2022-03-30
243 Coupled protein quality control during nonsense mediated mRNA decay
Inglis, A. J.; Guna, A.; Merchan, A. G.; Pal, A.; Esantsi, T. K.; Keys, H. R.; Frenkel, E. M.; Oania, R.; Weissman, J. S.; Voorhees, R. M.
10.1101/2021.12.22.473893 — molecular biology — Posted on 2022-03-30
244 Longitudinal monitoring of individual infection progression in Drosophila melanogaster
Ramirez-Corona, B. A.; Love, A. C.; Chandrasekaran, S.; Prescher, J. A.; Wunderlich, Z.
10.1101/2021.08.17.456698 — immunology — Posted on 2022-03-30
247 Human papillomavirus integration transforms chromatin to drive oncogenesis
Karimzadeh, M.; Arlidge, C.; Rostami, A.; Lupien, M.; Bratman, S. V.; Hoffman, M. M.
10.1101/2020.02.12.942755 — cancer biology — Posted on 2022-03-30
249 Neuroimaging within the Dominantly Inherited Alzheimer's Network (DIAN): PET and MRI
McKay, N. S.; Gordon, B. A.; Hornbeck, R. C.; Jack, C. R.; Koeppe, R.; Flores, S.; Keefe, S.; Hobbs, D. A.; Joseph-Mathurin, N.; Wang, Q.; Rahmani, F.; Chen, C. D.; McCullough, A.; Koudelis, D.; Chua, J.; Ances, B. M.; Millar, P. R.; Nickels, M. L.; Perrin, R. J.; Allegri, R. F.; Berman, S. B.; Brooks, W. S.; Cash, D. M.; Chhatwal, J. P.; Farlow, M. R.; Fox, N. C.; Fulham, M.; Ghetti, B.; Graff-Radford, N.; Ikeuchi, T.; Day, G. S.; Klunk, W.; Levin, J.; Lee, J.-H.; Martins, R.; Masters, C. L.; Mori, H.; McConathy, J.; Noble, J. M.; Rowe, C.; Salloway, S.; Sanchez-Valle, R.; Schofield, P. R.; S
10.1101/2022.03.25.485799 — neuroscience — Posted on 2022-03-30
251 TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana
Stitz, M.; Kuster, D.; Reinert, M.; Schepetilnikov, M.; Berthet, B.; Janocha, D.; Artins, A.; Boix, M.; Henriques, R.; Pfeiffer, A.; Lohmann, J. U.; Gaquerel, E.; Maizel, A.
10.1101/2022.03.29.486207 — plant biology — Posted on 2022-03-30
252 Warmer temperatures result in maladaptive learning of sexual preferences
Holveck, M.-J.; Muller, D.; Visser, B.; Timmermans, A.; Colonval, L.; Jan, F.; Crucifix, M.; Nieberding, C.
10.1101/2020.11.05.369561 — evolutionary biology — Posted on 2022-03-30
253 Staufen blocks autophagy in neurodegeneration
Paul, S.; Dansithong, W.; Gandelman, M.; Figueroa, K. P.; Zu, T.; Ranum, L. P. W.; Scoles, D. R.; Pulst, S. M.
10.1101/659649 — neuroscience — Posted on 2022-03-30
257 Cortical integration of higher-order thalamic inputs is lineage-dependent
Buchan, M. J.; Mahfooz, K.; van Rheede, J. J.; Gothard, G.; Avery, S. V.; Ellender, T. J.; Newey, S. E.; Akerman, C. J.
10.1101/2022.03.28.486015 — neuroscience — Posted on 2022-03-30
260 Glutathione-mediated plant response to high-temperature
Dard, A.; Bariat, L.; Weiss, A.; Picault, N.; Pontvianne, F.; Riondet, C.; Reichheld, J.-P.
10.1101/2022.03.28.485658 — plant biology — Posted on 2022-03-30
261 Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets
Van Moortel, L.; Thommis, J.; Maertens, B.; Staes, A.; Clarisse, D.; De Sutter, D.; Libert, C.; Meijer, O. C.; Eyckerman, S.; Gevaert, K.; De Bosscher, K.
10.1101/2022.03.29.486227 — pharmacology and toxicology — Posted on 2022-03-30
265 Evolution of genome fragility enables microbial division of labor
Colizzi, E. S.; van Dijk, B.; Merks, R. M. H.; Rozen, D. E.; Vroomans, R. M.
10.1101/2021.06.04.447040 — evolutionary biology — Posted on 2022-03-30
270 Mitigating biomass composition uncertainties in flux balance analysis using ensemble representations
Choi, Y.; Choi, D.-H.; Lee, Y. Q.; Koduru, L.; Lewis, N. E.; Lakshmanan, M.; Lee, D.-Y.
10.1101/652040 — systems biology — Posted on 2022-03-30
271 TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana
Stitz, M.; Kuster, D.; Reinert, M.; Schepetilnikov, M.; Berthet, B.; Janocha, D.; Artins, A.; Boix, M.; Henriques, R.; Pfeiffer, A.; Lohmann, J. U.; Gaquerel, E.; Maizel, A.
10.1101/2022.03.29.486207 — plant biology — Posted on 2022-03-30
273 Plasmid stability in fluctuating environments:population genetics of multi-copy plasmids
Miro Pina, V.; Hernandez-Beltran, J. C. R.; Siri-Jegousse, A.; Palau, S.; Pena-Miller, R.; Gonzalez-Casanova, A.
10.1101/2022.03.15.484385 — evolutionary biology — Posted on 2022-03-30
275 Molecular basis of uracil/H+ symport mechanism operated by the FurE/NCS1 transporter
Zantza, I.; Papadaki, G. F.; Raniolo, S.; Pyrris, Y.; Limongelli, V.; Diallinas, G.; Mikros, E.
10.1101/2022.03.28.486045 — molecular biology — Posted on 2022-03-30
276 The Human Motoneuron Expression Signature is Defined by ALS-Related Genes
Yadav, A.; Matson, K. J. E.; Li, L.; Hua, I.; Gaur, P.; Alkaslasi, M. R.; Hasan, S.; Galuta, A.; Dedek, A.; Ameri, S.; Parnell, J.; Alshardan, M. M.; Ququmji, F. A.; Alhamad, S. M.; Wang, A. P.; Poulen, G.; Lonjon, N.; Vachiery-Lahaye, F.; Nalls, M. A.; Nalls, M. A.; Qi, Y. A.; Hildebrand, M. E.; Mery, P.-F.; Bourinet, E.; Bauchet, L.; Tsai, E. C.; Ward, M. E.; Le Pichon, C.; Menon, V.; Levine, A.
10.1101/2022.03.25.485808 — neuroscience — Posted on 2022-03-30
277 Herbivore life histories are altered by drought stress in their hosts plants
Migeon, A.; Auger, P.; Fossati-Gaschigard, O.; Hufbauer, R. A.; Miranda, M.; Zriki, G.; Navajas, M.
10.1101/2021.10.21.465244 — zoology — Posted on 2022-03-30
278 ALLOPURINOL BLOCKS THE AORTIC ANEURYSM IN A MOUSE MODEL OF MARFAN SYNDROME VIA REDUCING AORTIC OXIDATIVE STRESS
Rodriguez-Rovira, I.; Arce, C.; Rycke, K. d.; Perez, B.; Carretereo, A.; Arbones, M.; Teixido-Tura, G.; Gomez-Cabrera, M. C.; Campuzano, V.; Jimenez-Altayo, F.; Egea, G.
10.1101/2021.10.13.464182 — pathology — Posted on 2022-03-30
279 Cryo-EM structure of amyloid fibril formed by α-synuclein familial A53E mutation
Jiang, L.; sun, c.; zhou, k.; DePaola, P.; Shin, W. S.; Hillyer, T.; Sawaya, M. R.; Zhou, H.
10.1101/2022.03.11.483992 — biophysics — Posted on 2022-03-30
282 Evolution of decreased aggression in honey bees targeted brain cell gene regulatory networks
Traniello, I. M.; Bukhari, S. A.; Dibaeinia, P.; Serrano, G.; Avalos, A.; Cash-Ahmed, A. C.; Sankey, A.; Hernaez, M.; Sinha, S.; Zhao, S. D.; Catchen, J. M.; Robinson, G. E.
10.1101/2022.03.29.486106 — genomics — Posted on 2022-03-30
283 THRONCAT: Efficient metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog
Ignacio, B. J.; Dijkstra, J.; MoraGarcia, N.; Slot, E.; van Weijsten, M.; Storkebaum, E.; Vermeulen, M.; Bonger, K. M.
10.1101/2022.03.29.486210 — cell biology — Posted on 2022-03-29
284 The maize gene maternal derepression of r1 (mdr1) encodes a DNA glycosylase that demethylates DNA and reduces siRNA expression in endosperm
Gent, J. I.; Higgins, K. M.; Swentowsky, K. W.; Fu, F.-F.; Zeng, Y.; Kim, D. W.; Dawe, R. K.; Springer, N. M.; Anderson, S. N.
10.1101/2021.10.04.463062 — genetics — Posted on 2022-03-29
285 Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity
Guet-McCreight, A.; Chameh, H. M.; Mahallati, S.; Wishart, M.; Tripathy, S. J.; Valiante, T. A.; Hay, E.
10.1101/2021.11.03.467014 — neuroscience — Posted on 2022-03-29
287 A Budding Yeast Model and Screen to Define the Functional Consequences of Oncogenic Histone Missense Mutations
Lemon, L. D.; Kanna, S.; Mo, K. W.; Adams, M.; Choi, H.; Gulka, A. O. D.; Withers, E. S.; Nurelegne, H. T.; Gomez, V.; Ambrocio, R. E.; Tumminkatti, R.; Lee, R. S.; Fasken, M. B.; Spangle, J. M.; Corbett, A. H.
10.1101/2021.10.02.462853 — genetics — Posted on 2022-03-29
291 ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication
Ganguly, T.; Peterson, A.; Burkholder, M.; Kajfasz, J. K.; Abranches, J.; Lemos, J. A.
10.1101/2022.03.29.486188 — microbiology — Posted on 2022-03-29
292 CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
Gummuluru, S.; Jalloh, S.; Olejnik, J.; Berrigan, J.; Nisa, A.; Suder, E. L.; Akiyama, H.; Lei, M.; Tyagi, S.; Bushkin, Y.; Muhlberger, E.
10.1101/2022.03.29.486190 — immunology — Posted on 2022-03-29
294 The Neurodata Without Borders ecosystem for neurophysiological data science
Ruebel, O.; Tritt, A. J.; Ly, R.; Dichter, B. K.; Ghosh, S. S.; Niu, L.; Soltesz, I.; Svoboda, K.; Frank, L. M.; Bouchard, K.
10.1101/2021.03.13.435173 — neuroscience — Posted on 2022-03-29
295 The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons
Bruckner, J. J.; Stednitz, S. J.; Grice, M. Z.; Zaidan, D.; Massaquoi, M. S.; Larsch, J. J.; Tallafuss, A.; Guillemin, K.; Washbourne, P.; Eisen, J.
10.1101/2020.05.01.071373 — neuroscience — Posted on 2022-03-29
297 Structural basis of actin filament assembly and aging
Oosterheert, W.; Klink, B. U.; Belyy, A.; Pospich, S.; Raunser, S.
10.1101/2022.03.29.486216 — biochemistry — Posted on 2022-03-29
298 Regulation of EBNA1 Protein Stability by PLOD1 Lysine Hydroxylase
Dheekollu, J.; Wiedmer, A.; Soldan, S. S.; Castro Munoz, L. J.; Tang, H.-Y.; Speicher, D. W.; Lieberman, P. M.
10.1101/2022.03.29.486189 — molecular biology — Posted on 2022-03-29
299 DNA methylation in human gastric epithelial cells allows cell type-related plasticity and defines regional identity
Fritsche, K.; Boccellato, F.; Schlaermann, P.; Koeppel, M.; Denecke, C.; Gut, I. G.; Meyer, T. F.; Berger, H.
10.1101/2022.03.29.486203 — molecular biology — Posted on 2022-03-29
300 Tuberculosis treatment failure associated with evolution of antibiotic resilience
Liu, Q.; Zhu, J.; Dulberger, C. L.; Stanley, S.; Wilson, S.; Chung, E. S.; Wang, X.; Culviner, P.; Liu, Y. J.; Hicks, N. D.; Babunovic, G. H.; Giffen, S. R.; Aldridge, B. B.; Garner, E. C.; Rubin, E. J.; Chao, M. C.; Fortune, S. M.
10.1101/2022.03.29.486233 — microbiology — Posted on 2022-03-29
303 Phylogenetic analysis of the origin and spread of plague in Madagascar
Esquivel Gomez, L. R.; Savin, C.; Andrianaivoarimanana, V.; Rahajandraibe, S.; Randriantseheno, L. N.; Zhou, Z.; Kocher, A.; Rajerison, M.; Didelot, X.; Kühnert, D.
10.1101/2022.03.29.486186 — microbiology — Posted on 2022-03-29
304 Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants
Lima, N. S.; Mukhamedova, M.; Johnston, T. S.; Wagner, D. A.; Henry, A. R.; Wang, L.; Yang, E. S.; Zhang, Y.; Birungi, K.; Black, W. P.; O'Dell, S.; Schmidt, S. D.; Moon, D.; Lorang, C. G.; Zhao, B.; Chen, M.; Boswell, K.; Roberts-Torres, J.; Davis, R. L.; Peyton, L.; Narpala, S. R.; O'Connell, S.; Wang, J.; Schrager, A.; Talana, C. A.; Leung, K.; Shi, W.; Khashab, R.; Biber, A.; Zilberman, T.; Rhein, J.; Vetter, S.; Ahmed, A.; Novik, L.; Widge, A.; Gordon, I.; Guech, M.; Teng, I.-T.; Phung, E.; Ruckwardt, T.; Pegu, A.; Misasi, J.; Doria-Rose, N. A.; Gaudinski, M.; Koup, R. A.; Kwong, P. D.; M
10.1101/2022.03.28.486152 — immunology — Posted on 2022-03-29
306 Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila
Scott, H.; Novikov, B.; Ugur, B.; Allen, B.; Mertsalov, I.; Monagas-Valentin, P.; Koff, M.; Baas Robinson, S.; Aoki, K.; Veizaj, R.; Lefeber, D.; Tiemeyer, M.; Bellen, H. J.; Panin, V.
10.1101/2022.03.29.486211 — neuroscience — Posted on 2022-03-29
307 spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape
Boniolo, F.; Hoffmann, M.; Roggendorf, N.; Tercan, B.; Baumbach, J.; Castro, M.; Robertson, A. G.; Saur, D.; List, M.
10.1101/2022.03.29.486212 — systems biology — Posted on 2022-03-29
308 Base editing screens map mutations affecting IFNγ signalling in cancer
Coelho, M. A.; Karakoc, E.; Bhosle, S. G.; Goncalves, E.; Burgold, T.; Cooper, S.; Cattaneo, C. M.; Veninga, V.; Consonni, S.; Dincer, C.; Vieira, S. F.; Gibson, F.; Barthorpe, S.; Hardy, C.; Rein, J.; Thomas, M.; Voest, E.; Bassett, A. R.; Garnett, M. J.
10.1101/2022.03.29.486051 — cancer biology — Posted on 2022-03-29
312 A multidisciplinary analysis of the as-isolated Escherichia coli SufBC2D complex reveals the presence of two new iron-sulfur clusters
Veronesi, G.; Perard, J.; Clemancey, M.; Gerez, C.; Duverger, Y.; Kieffer, I.; Barras, F.; Gambarelli, S.; Blondin, G.; ollagnier de choudens, s.
10.1101/2022.03.29.486248 — biochemistry — Posted on 2022-03-29
313 Subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing
Kaimal, J. M.; Tampere, M.; Le, T. H.; Axelsson, U.; Xu, H.; Axelsson, H.; Backstrom, A.; Marabita, F.; Moussaud-Lamodiere, E.; Njenda, D.; Sepulveda, C. O.; Ouyang, W.; Seashore-Ludlow, B.; Vernersson, C.; Mirazimi, A.; Lundberg, E.; Ostling, P.; Stadler, C.
10.1101/2022.03.29.482838 — cell biology — Posted on 2022-03-29
314 Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation
Solier, S.; Muller, S.; Caneque, T.; Versini, A.; Baron, L.; Gestraud, P.; Servant, N.; Emam, L.; Mansart, A.; Pantos, G. D.; Gandon, V.; Sencio, V.; Robin, C.; Trottein, F.; Begue, A.-L.; Salmon, H.; Durand, S.; Wu, T.-D.; Manel, N.; Puisieux, A.; Dawson, M. A.; Watson, S.; Kroemer, G.; Annane, D.; Rodriguez, R.
10.1101/2022.03.29.486253 — cell biology — Posted on 2022-03-29
316 Superfast Evolution of Multi-drug Antibiotic Resistance
Zhang, L.; Su, Q. P.; Guan, Y.; Cheng, Y. Y.; Cokcetin, N. N.; Bottomley, A.; Robinson, A.; Harry, E.; van Oijen, A. M.; Jin, D.
10.1101/2022.03.29.486198 — microbiology — Posted on 2022-03-29
318 The impact of the rice production system (irrigated vs lowland) on root-associated microbiome from farmer's fields in western Burkina Faso
Barro, M.; Wonni, I.; Simonin, M.; Kassankogno, A.; Klonowska, A.; Moulin, L.; Bena, G.; Somda, I.; Brunel, C.; Tollenaere, C.
10.1101/2022.03.29.486073 — microbiology — Posted on 2022-03-29
320 A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants
Zhang, J.; Han, Z. B.; Liang, Y.; Zhang, X. F.; Jin, Y. Q.; Du, L. F.; Shao, S.; Wang, H.; Hou, J. W.; Xu, K.; Lei, Z. H.; Liu, Z. M.; Zhang, J.; Hou, Y. N.; Liu, N.; Shen, F. J.; Wu, J. J.; Zheng, X.; Li, X. Y.; Li, X.; Huang, W. J.; Wu, G. Z.; Su, J. G.; Li, Q. M.
10.1101/2022.03.29.486173 — immunology — Posted on 2022-03-29
321 3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells
Salotti, J.; Karim, B.; Misra, S.; Hu, L.; Basu, S.; Martin, N.; Luke, B.; Saylor, K.; Andresson, T.; Scheiblin, D. A.; Lockett, S.; Tessarollo, L.; Johnson, P. F.
10.1101/2022.03.29.486281 — cancer biology — Posted on 2022-03-29
322 Spatial transcriptomic analysis of childhood ependymoma implicates unresolved wound healing as a driver of tumor progression
Fu, R.; Norris, G.; Willard, N.; Griesinger, A.; Riemondy, K. A.; Amani, V.; Grimaldo, E.; Harris, F.; Hankinson, T.; Mitra, S.; Ritzmann, t.; Grundy, R.; Foreman, N.; Donson, A.
10.1101/2022.03.29.486280 — cancer biology — Posted on 2022-03-29
326 Reproducible and sensitive micro-tissue RNA-sequencing from formalin-fixed paraffin-embedded tissue for spatial gene expression analysis
Matsunaga, H.; Arikawa, K.; Yamazaki, M.; Wagatsuma, R.; Ide, K.; Zachariah, S. A.; Takamochi, K.; Suzuki, K.; Hayashi, T.; Hosokawa, M.; Kambara, H.; Takeyama, H.
10.1101/2022.03.29.486169 — molecular biology — Posted on 2022-03-29
327 Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling
YANG, C.; Bachu, M.; Du, Y.; Brauner, C.; Yuan, R.; Ah Kioon, M. D.; Chesi, G.; Barrat, F. J.; Ivashkiv, L. B.
10.1101/2022.03.28.486089 — immunology — Posted on 2022-03-29
328 Comprehensive profiling of antibody responses to the human anellome using programmable phage display
Venkataraman, T.; Swaminathan, H.; Arze, C.; Jacobo, S. M.; Bhattacharyya, A.; David, T.; Nawandar, D.; Delagrave, S.; Mani, V.; Yozwiak, N. L.; Larman, H. B.
10.1101/2022.03.28.486145 — immunology — Posted on 2022-03-29
330 Molecular Control of Circuit Plasticity and the Permanence of Imprinted Odor Memory
Wu, Y.; Ma, L.; Qiu, Q.; Xu, W.; Misra, A.; Duyck, K.; Blanck, J.; Scott, A. R.; Chen, S.; Hassan, H.; Corbin, T. J.; Moran, A.; Hall, K.; Li, H.; Perera, A.; Yu, R.
10.1101/2022.03.29.486284 — neuroscience — Posted on 2022-03-29
332 Cell-free prototyping enables implementation of optimized reverse beta-oxidation pathways in heterotrophic and autotrophic bacteria
Vogeli, B.; Schulz, L.; Garg, S.; Tarasava, K.; Clomburg, J. M.; Lee, S. H.; Gonnot, A.; Moully, E. H.; Kimmel, B. R.; Tran, L.; Zeleznik, H.; Brown, S. D.; Simpson, S. D.; Mrksich, M.; Karim, A. S.; Gonzalez, R.; Koepke, M.; Jewett, M.
10.1101/2022.03.28.486064 — synthetic biology — Posted on 2022-03-29
334 Hip osteoarthritis: A novel network analysis of subchondral trabecular bone structures
Dorraki, M.; Muratovic, D.; Fouladzadeh, A.; Verjans, J. W.; Allison, A.; Findlay, D. M.; Abbott, D.
10.1101/2022.03.28.486155 — biophysics — Posted on 2022-03-29
337 Reference-based cell type matching of spatial transcriptomics data
Zhang, Y.; Miller, J. A.; Park, J.; Lelieveldt, B. P.; Aevermann, B. D.; Biancalani, T.; Comiter, C.; Mattsson Langseth, C.; Long, B.; Petukhov, V.; Scalia, G.; Vaishnav, E. D.; Zhao, Y.; Lein, E. S.; Scheuermann, R. H.
10.1101/2022.03.28.486139 — bioinformatics — Posted on 2022-03-29
338 The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro
McCloskey, M. C.; Kasap, P.; Ahmad, S. D.; Su, S.-H.; Chen, K.; Mansouri, M.; Ramesh, N.; Nishihara, H.; Belyaev, Y.; Abhyankar, V. V.; Begolo, S.; Singer, B. H.; Webb, K. F.; Kurabayashi, K.; Flax, J.; Waugh, R. E.; Engelhardt, B.; McGrath, J. L.
10.1101/2022.03.28.486095 — bioengineering — Posted on 2022-03-29
342 Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice.
Himelman, E.; Nouet, J.; Lillo, M.; Chong, A.; Wehrens, X.; Rodney, G.; Xie, L.; Shirokova, N.; Contreras, J. E.; Fraidenraich, D.
10.1101/2022.03.29.486276 — cell biology — Posted on 2022-03-29
345 Slc9a6 mutation causes Purkinje cell loss and ataxia in the spontaneous shaker rat
Figueroa, K. P.; Anderson, C. J.; Paul, S.; Dansithong, W.; Gandelman, M. M.; Scoles, D. R.; Pulst, S. M.
10.1101/2022.03.28.486143 — neuroscience — Posted on 2022-03-29
346 Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution
Woych, J.; Gurrola, A. O.; Deryckere, A.; Jaeger, E. C. B.; Gumnit, E.; Merello, G.; Gu, J.; Araus, A. J.; Leigh, N. D.; Yun, M.; Simon, A.; Tosches, M. A.
10.1101/2022.03.28.485354 — neuroscience — Posted on 2022-03-29
352 The Modular μSiM Reconfigured: Integration of Microfluidic Capabilities to Study in vitro Barrier Tissue Models under Flow
Mansouri, M.; Ahmed, A.; Ahamd, D.; McCloskey, M. C.; Joshi, I. M.; Gaborski, T. R.; Waugh, R. E.; McGrath, J. L.; Day, S. W.; Abhyankar, V. V.
10.1101/2022.03.28.486107 — bioengineering — Posted on 2022-03-29
353 Molecular basis of DNA recognition by the HMG-box-C1 module of Capicua
Webb, J.; Gnann, A. D.; Liew, J. J. M.; Patterson, M.; Paul, S.; Fores, M.; Jimenez, G.; Veraksa, A.; Dowling, D. P.
10.1101/2022.03.28.485992 — biochemistry — Posted on 2022-03-29
356 Post-activation depression produces extensor H-reflex suppression following flexor afferent conditioning
Metz, K. M.; Concha-Matos, I.; Hari, K.; Bseis, O.; Afsharipour, B.; Lin, S.; Li, Y.; Singla, R.; Fenrich, K.; Bennett, D. J.; Gorassini, M.
10.1101/2022.03.28.486118 — neuroscience — Posted on 2022-03-29
358 Profiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors
Polacco, B. J.; Lobingier, B. T.; Blythe, E. E.; Abreu, N.; Xu, J.; Li, Q.; Naing, Z. Z. C.; Shoichet, B. K.; Levitz, J.; Krogan, N. J.; Von Zastrow, M.; Huttenhain, R.
10.1101/2022.03.28.486115 — systems biology — Posted on 2022-03-29
359 Natural variation identifies new effectors of water use efficiency in Arabidopsis.
Badiger, B. G.; Lasky, J. R.; Razzaque, S.; Zhang, L.; Haque, T.; Bonnette, J. E.; Civelek, G. Z.; Verslues, P. E.; Juenger, T. E.
10.1101/2022.03.28.486113 — plant biology — Posted on 2022-03-29
360 Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics
Rodriguez-Meira, A.; Norfo, R.; Wen, W. X.; Chedeville, A. L.; Rahman, H.; OSullivan, J.; Wang, G.; Louka, E.; Kretzschmar, W.; Paterson, A.; Brierley, C.; Martin, J.-E.; Demeule, C.; Bashton, M.; Sousos, N.; Hamblin, A.; Guermouche, H.; Pasquier, F.; Marzac, C.; Girodon, F.; Drummond, M.; Harrison, C.; Plo, I.; Jacobsen, S. E. W.; Psaila, B.; Thongjuea, S.; Antony-Debre, I.; Mead, A. J.
10.1101/2022.03.28.485984 — cancer biology — Posted on 2022-03-29
362 CoCoA: Conditional Correlation Models with Association Size
Tu, D.; Mahony, B.; Moore, T. M.; Bertolero, M. A.; Alexander-Bloch, A. F.; Gur, R.; Bassett, D. S.; Satterthwaite, T. D.; Raznahan, A.; Shinohara, R. T.
10.1101/2022.03.28.486098 — bioinformatics — Posted on 2022-03-29
366 Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability
Brouwer, P. J. M.; Antanasijevic, A.; Ronk, A. J.; Mulller-Krauter, H.; Watanabe, Y.; Claireaux, M.; Lloyd, N. M.; Bijl, T. P. L.; Perrett, H. R.; Steijaert, T. H.; Burger, J. A.; van Haaren, M. M.; Sliepen, K.; van Gils, M.; Crispin, M.; Strecker, T.; Bukreyev, A.; Ward, A.; Sanders, R. W.
10.1101/2022.03.28.486091 — immunology — Posted on 2022-03-29
369 Sparcl1/Hevin drives inflammatory and neuropathic pain through astrocyte and NMDA receptor signaling
Chen, G.; Luo, H.; Luo, X.; Singh, S. K.; Ramirez, J. J.; James, M. L.; Mathew, J. P.; Berger, M.; Eroglu, C.; Ji, R. R.
10.1101/2022.03.28.486142 — neuroscience — Posted on 2022-03-29
371 Local translation provides the asymmetric distribution of CaMKII required for associative memory formation
Chen, N.; Zhang, Y.; Adel, M.; Kuklin, E. A.; Reed, M. L.; Mardovin, J.; Bakthavachalu, B.; Vijayraghavan, K.; Ramaswami, M.; Griffith, L. C.
10.1101/2022.03.28.486096 — neuroscience — Posted on 2022-03-29
372 Transcriptional control of nucleus accumbens neuronal excitability by Retinoid X Receptor Alpha tunes sensitivity to drug rewards
Godino, A.; Salery, M.; Durand-de Cuttoli, R.; Estill, M. S.; Holt, L. M.; Futamura, R.; Browne, C. J.; Mews, P.; Hamilton, P. J.; Neve, R. L.; Shen, L.; Russo, S. J.; Nestler, E. J.
10.1101/2022.03.28.486101 — neuroscience — Posted on 2022-03-29
373 Inflammaging in human photoexposed skin: Early onset of senescence and imbalanced epidermal homeostasis across the decades.
Jarrold, B. B.; Tan, C.; Ho, C. Y.; Soon, A. L.; Lam, T. T.; Yang, X.; Nguyen, C.; Guo, W.; Chew, Y. C.; DeAngelis, Y. M.; Costello, L.; Gomez, P. D. L. S.; Przyborski, S.; Bellanger, S.; Dreesen, O.; Kimball, A.; Oblong, J.
10.1101/2022.03.28.486066 — systems biology — Posted on 2022-03-29
378 A novel cis-element enabled bacterial uptake by plant cells
Cathebras, C.; Gong, X.; Andrade, R. E.; Vondenhoff, K.; Hayashi, M.; Keller, J.; Delaux, P.-M.; Griesmann, M.; Parniske, M.
10.1101/2022.03.28.486070 — plant biology — Posted on 2022-03-29
379 The hidden intricacies of aquaporins: Remarkable details in a common structural scaffold
Gössweiner-Mohr, N.; Siligan, C.; Pluhackova, K.; Umlandt, L. A. S.; Koefler, S.; Trajkovska, N.; Horner, A.
10.1101/2022.03.28.486021 — bioinformatics — Posted on 2022-03-29
380 High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts
Schwartz, U.; Llamazares Prada, M.; Pohl, S. T.; Richter, M.; Tamas, R.; Schuler, M.; Keller, C.; Mijosek, V.; Muley, T.; Schneider, M. A.; Quast, K.; Hey, J.; Heussel, C. P.; Warth, A.; Winter, H.; Sercin, O.; Karmouty-Quintana, H.; Herth, F. J.; Koch, I.; Petrosino, G.; Mardin, B.; Weichenhan, D.; Jurkowski, T. P.; Imbusch, C.; Brors, B.; Benes, V.; Jung, B.; Wyatt, D.; Stahl, H.; Plass, C.; Jurkowska, R.
10.1101/2022.03.28.486023 — cell biology — Posted on 2022-03-29
381 Glial dysregulation in human brain in Fragile X-related disorders
Dias, C. M.; Talukdar, M.; Akula, S.; Walsh, K. G.; Walsh, C. A.
10.1101/2022.03.29.486195 — neuroscience — Posted on 2022-03-29
385 Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP
Manakov, S. A.; Shishkin, A. A.; Yee, B. A.; Shen, K. A.; Cox, D. C.; Park, S. S.; Foster, H. M.; Chapman, K. B.; Yeo, G. W.; Van Nostrand, E. L.
10.1101/2022.02.13.480296 — genomics — Posted on 2022-03-29
386 Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease
D'Antonio, M.; Arthur, T. D.; Nguyen, J. P.; Matsui, H.; D'Antonio-Chronowska, A.; Frazer, K. A.
10.1101/2021.09.01.458619 — genetics — Posted on 2022-03-29
387 Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
Mohammadi, S.; Herrera-Alvarez, S.; Yang, L.; Rodriguez-Ordonez, M. d. P.; Zhang, K.; Storz, J.; Dobler, S.; Crawford, A. J.; Andolfatto, P.
10.1101/2021.11.29.470343 — evolutionary biology — Posted on 2022-03-29
388 Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active against Multi-drug resistant Tuberculosis
Dashti, Y.; Mohammadipanah, F.; Belousoff, M. J.; Vocat, A.; Zabala, D.; Fage, C. D.; Romero-Canelon, I.; Bunk, B.; Sproer, C.; Overmann, J.; Cole, S. T.; Challis, G. L.
10.1101/2021.10.24.465558 — microbiology — Posted on 2022-03-29
391 Glutathione-mediated plant response to high-temperature
Dard, A.; Bariat, L.; Weiss, A.; Picault, N.; Pontvianne, F.; Riondet, C.; Reichheld, J.-P.
10.1101/2022.03.28.485658 — plant biology — Posted on 2022-03-29
393 A single-cell clusters similarity measure for different batches, datasets, and samples
Gonzalez-Velasco, O.; Sanchez-Luis, E.; De La Rosa, E.; Sanchez-Santos, J. M.; De Las Rivas, J.
10.1101/2022.03.14.483731 — bioinformatics — Posted on 2022-03-29
394 Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease
Sommerer, Y.; Dobricic, V.; Schilling, M.; Ohlei, O.; Sabet, S. S.; Wesse, T.; Fuss, J.; Franzenburg, S.; Franke, A.; Parkkinen, L.; Lill, C. M.; Bertram, L.
10.1101/2021.07.02.450878 — genomics — Posted on 2022-03-29
395 Discordant genotype calls across technology platforms elucidate variants with systematic errors in next-generation sequencing
Atkinson, E. G.; Artomov, M.; Karczewski, K. J.; Loboda, A. A.; Rehm, H. L.; MacArthur, D. G.; Neale, B. M.; Daly, M. J.
10.1101/2022.03.24.485707 — genomics — Posted on 2022-03-29
397 Epidermal Growth Factor Receptor Inhibition Prevents Caveolin-1-dependent Calcifying Extracellular Vesicle Biogenesis
Nik, A. B.; Ng, H. H.; Sun, P.; Iacoviello, F.; Shearing, P. R.; Bertazzo, S.; Mero, D.; Khomtchouk, B. B.; Hutcheson, J. D.
10.1101/2021.11.08.467799 — pathology — Posted on 2022-03-29
399 vcferr: Development, Validation, and Application of a SNP Genotyping Error Simulation Framework
Nagraj, V. P.; Scholz, M.; Jessa, S.; Ge, J.; Woerner, A. E.; Huang, M.; Budowle, B.; Turner, S. D.
10.1101/2022.03.28.485853 — bioinformatics — Posted on 2022-03-29
400 Resistance of mitochondrial DNA to chemical-induced germline mutations is independent of mitophagy in C. elegans
Leuthner, T.; Benzing, L. C.; Kohrn, B.; Bergemann, C.; Hipp, M.; Hershberger, K.; Mello, D. F.; Sokolskyi, T.; Merutka, I.; Seay, S.; Kennedy, S. R.; Meyer, J.
10.1101/2022.03.28.486090 — genomics — Posted on 2022-03-29
402 Pangenomics provides insights into the role of synanthropy in barn swallow evolution
Secomandi, S.; Gallo, G. R.; Sozzoni, M.; Iannucci, A.; Galati, E.; Abueg, L.; Balacco, J.; Caprioli, M.; Chow, W.; Ciofi, C.; Collins, J.; Fedrigo, O.; Ferretti, L.; Fungtammasan, A.; Haase, B.; Howe, K.; Kwak, W.; Lombardo, G.; Masterson, P.; Messina, G.; Moller, A. P.; Mountcastle, J.; Mousseau, T. A.; Ferrer-Obiol, J.; Olivieri, A.; Rhie, A.; Rubolini, D.; Saclier, M.; Stanyon, R.; Stucki, D.; Thibaud-Nissen, F.; Torrance, J.; Torroni, A.; Weber, K.; Ambrosini, R.; Bonisoli-Alquati, A.; Jarvis, E. D.; Gianfranceschi, L.; Formenti, G.
10.1101/2022.03.28.486082 — genomics — Posted on 2022-03-29
403 Genome sequence of 12 Vigna species as a knowledge base of stress tolerance and resistance
Naito, K.; Wakatake, T.; Shibata, T. F.; Iseki, K.; Shigenobu, S.; Takahashi, Y.; Ogiso-Tanaka, E.; Muto, C.; Teruya, K.; Shiroma, A.; Shimoji, M.; Satou, K.; Hirano, T.; Nagano, A. J.; Tomooka, N.; Hasebe, M.; Fukushima, K.; Sakai, H.
10.1101/2022.03.28.486085 — genomics — Posted on 2022-03-29
404 High Quality Phasing Using Linked-Read Whole Genome Sequencing of Patient Cohorts Informs Genetic Understanding of Complex Traits
Mastromatteo, S.; Chen, A.; Gong, J.; Lin, F.; Thiruvahindrapuram, B.; Sung, W. W.; Whitney, J.; Wang, Z.; Patel, R. V.; Keenan, K.; Halevy, A.; Panjwani, N.; Avolio, J.; Wang, C.; Cote-Maurais, G.; Begin, S.; Adam, D.; Brochiero, E.; Bjornson, C.; Chilvers, M.; Price, A.; Parkins, M.; van Wylick, R.; Mateos-Corral, D.; Hughes, D.; Smith, M. J.; Morrison, N.; Tullis, E.; Stephenson, A. L.; Wilcox, P.; Quon, B. S.; Leung, W. M.; Solomon, M.; Sun, L.; Ratjen, F.; Strug, L. J.
10.1101/2022.03.28.486092 — genetics — Posted on 2022-03-29
407 Molecular characterization of cell types in the squid Loligo vulgaris
Duruz, J.; Sprecher, M.; Kaldun, J.; Alsoudy, A.; Tschanz-Lischer, H.; van Geest, G.; Nicholson, P.; Bruggmann, R.; Sprecher, S. G.
10.1101/2022.03.28.485983 — developmental biology — Posted on 2022-03-29
408 Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure Closure
Boobalan, E.; Thompson, A. H.; Alur, R. P.; McGaughey, D.; Dong, L.; Shi, G.; Vieta-Ferrer, E.; Onojafe, I. F.; Kalaskar, V.; Arno, G.; Lotery, A. J.; Guan, B.; Bender, C.; Memon, O.; Brinster, L.; Soleilhavoup, C.; Panman, L.; Badea, T. C.; Minella, A.; Lopez, A. J.; Thomasy, S.; Moshiri, A.; Genomics England Research Consortium, ; Blain, D.; Hufnagel, R. B.; Cogliati, T.; Bharti, K.; Brooks, B. P.
10.1101/2022.03.28.486078 — developmental biology — Posted on 2022-03-29
409 Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells
Du, L.; Bouzidi, M. S.; Gala, A.; Deiter, F.; Billaud, J.-N.; Yeung, S.; Dabral, P.; Jin, J.; Simmons, G.; Dossani, Z.; Niki, T.; Ndhlovu, L.; Greenland, J.; Pillai, S. K.
10.1101/2022.03.18.484956 — microbiology — Posted on 2022-03-29
411 NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration
Ultanir, S. K.; Rosianu, F.; Mihaylov, S. R.; Eder, N.; Martiniuc, A.; Claxton, S.; Flynn, H.; Jalal, S.; Domart, M.-C.; Collinson, L. M.; Skehel, M.; Snijders, A. P. P.; Krause, M.; Tooze, S. A.
10.1101/2022.03.28.486054 — neuroscience — Posted on 2022-03-29
412 An integrated resource for functional and structural connectivity of the marmoset brain
Tian, X.; Chen, Y.; Majka, P.; Szczupak, D.; Sanz-Perl, Y.; Yen, C. C.-C.; Tong, C.; Song, K.; Jiang, H.; Glen, D.; Deco, G.; Rosa, M. G. P.; Silva, A. C.; Liang, Z.; Liu, C.
10.1101/2021.11.12.468389 — neuroscience — Posted on 2022-03-29
413 STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale
Chen, W.; Carel, T.; Awile, O.; Cantarutti, N.; Castiglioni, G.; Cattabiani, A.; Del Marmol, B.; Hepburn, I.; King, J. G.; Kotsalos, C.; Kumbhar, P.; Lallouette, J.; Melchior, S.; Schürmann, F.; De Schutter, E.
10.1101/2022.03.28.485880 — neuroscience — Posted on 2022-03-29
416 Deciphering the fibre-orientation independent component of R2* (R2,iso*) in the human brain with a single multi-echo gradient-recalled-echo measurement under varying microstructural conditions
Fritz, F. J.; Mordhorst, L.; Ashtarayeh, M.; Periquito, J.; Pohlmann, A.; Morawski, M.; Jaeger, C.; Niendorf, T.; Pine, K. J.; Callaghan, M. F.; Weiskopf, N.; Mohammadi, S.
10.1101/2022.03.28.486076 — neuroscience — Posted on 2022-03-29
419 Glutathione-mediated plant response to high-temperature
Dard, A.; Bariat, L.; Weiss, A.; Picault, N.; Pontvianne, F.; Riondet, C.; Reichheld, J.-P.
10.1101/2022.03.28.485658 — plant biology — Posted on 2022-03-29
421 The response network of HSP70 defines vulnerabilities in cancer cells with the inhibited proteasome
Oron, M.; Grochowski, M.; Jaiswar, A.; Legierska, J.; Jastrzebski, K.; Nowak-Niezgoda, M.; Kolos, M.; Kazmierczak, W.; Olesinski, T.; Lenarcik, M.; Cybulska, M.; Mikula, M.; Zylicz, A.; Miaczynska, M.; Zettl, K.; Wisniewski, J. R.; Walerych, D.
10.1101/2021.11.16.468807 — cancer biology — Posted on 2022-03-29
422 Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling
Palakurthi, B.; Guldner, I. H.; Liu, X.; Martino, A. K.; Wang, Q.; Fross, S.; Neff, R. A.; Golomb, S. M.; Howe, E.; Zhang, S.
10.1101/2022.03.28.485781 — cancer biology — Posted on 2022-03-29
424 Wochenende - modular and flexible alignment-based shotgun metagenome analysis
Rosenboom, I.; Scheithauer, T.; Friedrich, F. C.; Poertner, S.; Pust, M.-M.; Sifakis, K.; Wehrbein, T.; Rosenhahn, B.; Wiehlmann, L.; Chhatwal, P.; Tuemmler, B.; Davenport, C. F.
10.1101/2022.03.18.484377 — bioinformatics — Posted on 2022-03-29
428 Croatian Genetic Heritage: Renewed Y Chromosome Story a Decade Later
Primorac, D.; Skaro, V.; Projic, P.; Missoni, S.; Horjan Zanki, I.; Merkas, S.; Sarac, J.; Novokmet, N.; Ledic, A.; Makar, A.; Lauc, G.; Andelinovic, S.; Basic, Z.; Kruzic, I.; Neuberg, M.; Smolic, M.; Smolic, R.; Hrstic, I.; Trivanovic, D.; Konjhodzic, R.; Salihefendic, L.; Babic Jordamovic, N.; Marjanovic, D.
10.1101/2022.03.21.485134 — evolutionary biology — Posted on 2022-03-29
431 Transient accumulation and bidirectional movement of KIF13B in primary cilia
Juhl, A. D.; Anvarian, Z.; Kuhns, S.; Berges, J.; Andersen, J. S.; Wustner, D.; Pedersen, L. B.
10.1101/2021.07.09.451768 — cell biology — Posted on 2022-03-29
432 Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjogrens syndrome
Yoon, J.; Lee, M.; Ali, A. A.; Oh, Y. R.; Choi, Y. S.; Kim, S.; Lee, N.; Jang, S. G.; Kwok, S.-K.; Hyon, J. Y.; Cha, S.; Lee, Y. J.; Im, S. G.; Kim, Y.
10.1101/2021.09.13.459934 — molecular biology — Posted on 2022-03-29
434 A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
Heuss, C.; Rothhaar, P.; Burm, R.; Lee, J.-Y.; Haselmann, U.; Ströh, L. J.; Ralfs, P.; Colasanti, O.; Tran, C. S.; Schäfer, N.; Schnitzler, P.; Merle, U.; Bartenschlager, R.; Patel, A. H.; Graw, F.; Krey, T.; Laketa, V.; Meuleman, P.; Lohmann, V.
10.1101/2022.03.28.486019 — microbiology — Posted on 2022-03-29
435 Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus
Rush, S. A.; Brar, G.; Hsieh, C.-L.; Chautard, E.; Rainho-Tomko, J. N.; Slade, C.; Bricault, C. A.; Kume, A.; Kearns, J.; Groppo, R.; Mundle, S.; Zhang, L.; Casimiro, D.; Fu, T.-M.; DiNapoli, J. M.; McLellan, J. S.
10.1101/2022.03.28.486060 — immunology — Posted on 2022-03-29
439 LTD-inducing low frequency stimulation enhances p-Tau181 and p-Tau217 in an age-dependent manner in live rats
Hu, N.-W.; Zhang, Y.; Yang, Y.; Hu, Z.; Zhu, M.; Qin, S.; Yu, P.; Li, B.; Xu, J.; Rowan, M. J.
10.1101/2022.03.28.486022 — neuroscience — Posted on 2022-03-29
441 Increasing plant group productivity through latent genetic variation for cooperation
Wuest, S. E.; Pires, N. D.; Luo, S.; Vasseur, F.; Messier, J.; Grossniklaus, U.; Niklaus, P. A.
10.1101/641449 — plant biology — Posted on 2022-03-29
442 Algal photosystem I dimer and high resolution model of PSI:plastocyanin complex
Naschberger, A.; Mosebach, L.; Tobiasson, V.; Kuhlgert, S.; Scholz, M.; Perez-Boerema, A.; Ho, T. T. H.; Vidal-Meireles, A.; Takahashi, Y.; Hippler, M.; Amunts, A.
10.1101/2021.08.30.458224 — plant biology — Posted on 2022-03-29
443 Identification of a novel chalcone reductase gene for isoliquiritigenin biosynthesis in dahlia (Dahlia variabilis)
Ohno, S.; Yamada, H.; Maruyama, K.; Deguchi, A.; Kato, Y.; Yokota, M.; Tatsuzawa, F.; Hosokawa, M.; Doi, M.
10.1101/2022.03.28.486017 — plant biology — Posted on 2022-03-29
444 Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation
Dufour, D.; Dumontet, T.; Sahut-Barnola, I.; Onzon, M.; Pussard, E.; Wilmouth, J.; Olabe, J.; Lucas, C.; Levasseur, A.; Pointud, J.-C.; Roucher-Boulez, F.; Tauveron, I.; Bossis, G.; Breault, D.; Yeh, E. T.; Val, P.; Lefrancois-Martinez, A. M.; Martinez, A.
10.1101/2022.02.08.479354 — physiology — Posted on 2022-03-29
445 A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia
Marin-Rubio, J. L.; Heap, R. E.; Heunis, T.; Duenas, M. E.; Inns, J.; Scott, J.; Simpson, A. J.; Allan, J. M.; Blair, H.; Heidenreich, O.; Saxty, B.; Trost, M.
10.1101/2021.03.29.437557 — cancer biology — Posted on 2022-03-29
447 Evolution of genome fragility enables microbial division of labor
Colizzi, E. S.; van Dijk, B.; Merks, R. M. H.; Rozen, D. E.; Vroomans, R. M.
10.1101/2021.06.04.447040 — evolutionary biology — Posted on 2022-03-29
451 Improving the Safety of Cultured Meat Using Basal Medium Prepared using Food Ingredients
Kanayama, T.; Tanaka, K.; Shimada, H.; Ichiyama, K.; Higuchi, S.; Kawashima, I.
10.1101/2022.03.28.486069 — cell biology — Posted on 2022-03-29
452 A multiplexed in vivo approach to identify driver genes in small cell lung cancer
Lee, M. C.; Cai, H.; Murray, C. W.; Li, C.; Shue, Y. T.; Andrejka, L.; He, A. L.; Holzem, A.; Drainas, A. P.; Ko, J. H.; Coles, G. L.; Kong, C.; Zhu, S.; Zhu, C.; Wang, J.; van de Rijn, M.; Petrov, D. A.; Winslow, M. M.; Sage, J.
10.1101/2022.03.28.485708 — cancer biology — Posted on 2022-03-29
455 Cortical integration of higher-order thalamic inputs is lineage-dependent
Buchan, M. J.; Mahfooz, K.; van Rheede, J. J.; Gothard, G.; Avery, S. V.; Ellender, T. J.; Newey, S. E.; Akerman, C. J.
10.1101/2022.03.28.486015 — neuroscience — Posted on 2022-03-29
456 Serotonin Modulates an Inhibitory Input to the Central Amygdala from the Ventral Periaqueductal Gray
Hon, O.; Diberto, J.; Mazzone, C.; Sugam, J.; Bloodgood, D. W.; Hardaway, A.; Husain, M.; Kendra, A.; McCall, N.; Lopez, A.; kash, t.; Lowery-Gionta, E.
10.1101/2022.03.28.486055 — neuroscience — Posted on 2022-03-29
459 Safety assessment of insecticidal proteins: A case study utilizing His-tagged protein to determine the safety of Mpp75Aa1.1, a new ETX_MTX2 protein that controls western corn rootworm
Wang, C.; Bean, G. J.; Chen, C. J.; Kessenich, C. R.; Peng, J.; Visconti, N. R.; Milligan, J. S.; Moore, R. G.; Tan, J.; Edrington, T. c.; Li, B.; Giddings, K. S.; Bowen, D.; Luo, J.; Ciche, T.; Moar, W. J.
10.1101/2022.03.28.486136 — pharmacology and toxicology — Posted on 2022-03-28
462 Molecular basis of uracil/H+ symport mechanism operated by the FurE/NCS1 transporter
Zantza, I.; Papadaki, G. F.; Raniolo, S.; Pyrris, Y.; Limongelli, V.; Diallinas, G.; Mikros, E.
10.1101/2022.03.28.486045 — molecular biology — Posted on 2022-03-28
463 Long-term stability of neural activity in the motor system
Jensen, K. T.; Harpaz, N. K.; Dhawale, A. K.; Wolff, S. B. E.; Ölveczky, B.
10.1101/2021.10.27.465945 — neuroscience — Posted on 2022-03-28
464 Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Ceddia, R. P.; Zurawski, Z.; Thompson Gray, A.; Adegboye, F.; Shi, F.; Liu, D.; Maldonado, J.; Ayala, J. E.; McGuinness, O. P.; Collins, S.; Hamm, H. E.
10.1101/2020.04.29.069138 — physiology — Posted on 2022-03-28
465 Mitigating the Bfl-1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs
Yoon, S.-s.; Park, E.; Lee, C.; Park, J.; Liu, J.; Hong, J.; Shin, D.-Y.; Byun, J. M.; Yun, H.; Koh, Y.
10.1101/2022.03.28.486020 — cancer biology — Posted on 2022-03-28
469 Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae
Alfatah, M.; Cui, L.; Goh, C. J. H.; Wong, J. H.; Lewis, J.; Poh, W. J.; Arumugam, P.
10.1101/2022.03.25.485766 — genetics — Posted on 2022-03-28
473 Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models
Cohen, A. A.; van Doremalen, N. A.; Greaney, A. J.; Andersen, H.; Sharma, A.; Starr, T. N.; Keeffe, J. R.; Fan, C.; Schulz, J. E.; Gnanapragasam, P. N. P.; Kakutani, L. M.; West, A. P.; Saturday, G.; Lee, Y. E.; Gao, H.; Jette, C. A.; Lewis, M. G.; Tan, T. K.; Townsend, A. R.; Bloom, J. D.; Munster, V. J.; Bjorkman, P. J.
10.1101/2022.03.25.485875 — microbiology — Posted on 2022-03-28
475 Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients
Hoffmann, A. D.; Weinberg, S.; Swaminathan, S.; Chaudhuri, S.; Mubarak, H.; Schipma, M.; Mao, C.; Wang, X.; El-Shennawy, L.; Dashzeveg, N.; Wei, J.; Mehl, P.; Shihadah, L.; Wai, C. M.; Ostiguin, C.; Jia, Y.; D'Amico, P.; Wang, N.; Luo, Y.; Demonbreun, A.; Ison, M.; Liu, H.; Fang, D.
10.1101/2022.03.26.485922 — immunology — Posted on 2022-03-28
480 Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse models
Chang, S.; Fulmer, D.; Hur, S. K.; Thorvaldsen, J. L.; Li, L.; Lan, Y.; Rhon-Calderon, E.; Chen, X.; Epstein, J. A.; Bartolomei, M. S.
10.1101/2022.03.28.486058 — developmental biology — Posted on 2022-03-28
481 GLOBAL HOST RESPONSES TO THE MICROBIOTA AT SINGLE CELL RESOLUTION IN GNOTOBIOTIC ZEBRAFISH
Massaquoi, M. S.; Kong, G.; Chilin, D.; Hamilton, M. K.; Melancon, E.; Eisen, J.; Guillemin, K.
10.1101/2022.03.28.486083 — developmental biology — Posted on 2022-03-28
484 A Rapid, High Throughput, Viral Infectivity Assay using Automated Brightfield Microscopy with Machine Learning
Dodkins, R. H.; Delaney, J. R.; Overton, T.; Scholle, F.; Frias, A.; Crisci, E.; Huq, N.; Jordan, I.; Kimata, J. T.; Goldberg, I. G.
10.1101/2022.03.23.485512 — microbiology — Posted on 2022-03-28
485 An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2
Zhang, L.; Narayanan, K. K.; Cooper, L.; Chan, K. K.; Devlin, C. A.; Aguhob, A.; Shirley, K.; Rong, L.; Rehman, J.; Malik, A. B.; Procko, E.
10.1101/2022.03.28.486075 — microbiology — Posted on 2022-03-28
486 Distinct Colon Mucosa Microbiomes associated with Tubular Adenomas and Serrated Polyps
Avelar-Barragan, J.; DeDecker, L.; Lu, Z.; Coppedge, B.; Karnes, W.; Whiteson, K.
10.1101/2021.07.20.453135 — microbiology — Posted on 2022-03-28
487 A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model
Johnston, S. C.; Ricks, K. M.; Lakhal-Naouar, I.; Jay, A.; Subra, C.; Raymond, J. L.; King, H. A. D.; Rossi, F.; Clements, T. L.; Fetterer, D.; Tostenson, S.; Cincotta, C. M.; Hack, H. R.; Kuklis, C.; Soman, S.; King, J.; Peachman, K. K.; Kim, D.; Chen, W.-H.; Sankhala, R. S.; Martinez, E. J.; Hajduczki, A.; Chang, W. C.; Choe, M.; Thomas, P. V.; Peterson, C. E.; Anderson, A.; Swafford, I.; Currier, J. R.; Paquin-Proulx, D.; Jagodzinski, L. L.; Matyas, G. R.; Rao, M.; Gromowski, G. D.; Peel, S. A.; White, L.; Smith, J. M.; Hooper, J. W.; Michael, N. L. L.; Modjarrad, K.; Joyce, M. G.; Nalca, A
10.1101/2022.03.25.485832 — microbiology — Posted on 2022-03-28
488 Effects of variability in manually contoured spinal cord masks on fMRI co-registration and interpretation
Hoggarth, M. A.; Wang, M. C.; Hemmerling, K. J.; Vigotsky, A. D.; Smith, Z. A.; Parrish, T. B.; Weber, K. A.; Bright, M. G.
10.1101/2022.03.25.485810 — neuroscience — Posted on 2022-03-28
490 Fast parametric curve matching (FPCM) for automatic spike detection
Kleeva, D.; Soghoyan, G.; Komoltsev, I.; Sinkin, M.; Ossadtchi, A.
10.1101/2021.12.31.474621 — neuroscience — Posted on 2022-03-28
492 Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling
Zhang, S.; Palakurthi, B.; Guldner, I. H.; Liu, X.; Martino, A. K.; Wang, Q.; Fross, S.; Neff, R. A.; Golomb, S. M.; Howe, E.
10.1101/2022.03.28.485781 — cancer biology — Posted on 2022-03-28
493 Membrane phase separation drives organization at B cell receptor clusters
Shelby, S. A.; Castello-Serrano, I.; Wisser, K.; Levental, I.; Veatch, S.
10.1101/2021.05.12.443834 — biophysics — Posted on 2022-03-28
494 Transient Water Wires Mediate Selective Proton Conduction in Designed Channel Proteins
Kratochvil, H. T.; Watkins, L. C.; Mravic, M.; Thomaston, J. L.; Nicoludis, J. M.; Liu, L.; Voth, G. A.; DeGrado, W.
10.1101/2022.03.28.485852 — biophysics — Posted on 2022-03-28
495 Linked machine learning classifiers improve species classification of fungi when using error-prone long-reads on extended metabarcodes
Eenjes, T.; Hu, Y.; Irinyi, L.; Hoang, M. T.; Smith, L.; Linde, C.; Meyer, W.; Stone, E.; Rathjen, J. P.; Mashford, B.; Schwessinger, B.
10.1101/2021.05.01.442223 — bioinformatics — Posted on 2022-03-28
496 The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response.
Enguita, F. J.; Leitao, A. L.; McDonald, J. T.; Zaksas, V.; Das, S.; Galeano, D.; Taylor, D.; Syrkin Wurtele, E.; Saravia-Butler, A.; Baylin, S. B.; Meller, R.; Porterfield, D. M.; Wallace, D. C.; Schisler, J. C.; Mason, C. E.; Beheshti, A.
10.1101/2022.03.26.485903 — bioinformatics — Posted on 2022-03-28
497 Genetically engineered MRI-trackable extracellular vesicles as SARS-CoV-2 mimetics for mapping ACE2 binding in vivo
Galisova, A.; Zahradnik, J.; Allouche-Arnon, H.; Morandi, M. I.; Abou Karam, P.; Avinoam, O.; Regev-Rudzki, N.; Schreiber, G.; Bar-Shir, A.
10.1101/2022.03.27.485958 — bioengineering — Posted on 2022-03-28
499 Sperm mosaicism predicts transmission of de novo mutations to human blastocysts
Yang, X.; Stanley, V.; McEvoy-Venneri, J.; Xu, X.; Morales, A. J.; Gleeson, J. G.; Breuss, M. W.
10.1101/2022.03.28.486034 — genetics — Posted on 2022-03-28
500 MOSAIC: A Unified Trait Database to Complement Structured Population Models
Bernard, C.; Santos, G. S.; Deere, J.; Rodriguez-Caro, R.; Capdevila, P.; Kusch, E.; Gascoigne, S.; Jackson, J.; Salguero-Gomez, R.
10.1101/2022.03.09.483599 — ecology — Posted on 2022-03-28
501 A general deep learning model for bird detection in high resolution airborne imagery
Weinstein, B. G.; Gardner, L.; Saccomanno, V.; Steinkraus, A.; Ortega, A.; Brush, K.; Yenni, G.; McKellar, A. E.; Converse, R.; Lippitt, C.; Wegmann, A.; Holmes, N. D.; Edney, A. J.; Hart, T.; Jessopp, M. J.; Clarke, R.; Marchowksi, D.; Senyondo, H.; Dotson, R.; White, E. P.; Frederick, P.; Ernest, S. K. M.
10.1101/2021.08.05.455311 — ecology — Posted on 2022-03-28
505 A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
Collins, S.; Van Vliet, L.; Gielen, F.; Janecek, M.; Wagner Valladolid, S.; Poudel, C.; Fusco, G.; De Simone, A.; Michel, C.; Kaminski, C. F.; Spring, D. R.; Hollfelder, F.; Kaminski Schierle, G. S.
10.1101/2022.03.28.485913 — molecular biology — Posted on 2022-03-28
506 Exploring a novel genomic safe-haven site in the human pathogenic mould Aspergillus fumigatus.
Furukawa, T.; van Rhijn, N.; Chown, H.; Rhodes, J.; Alfuraji, N.; Fortune-Grant, R.; Bignell, E.; Fisher, M. C.; Bromley, M.
10.1101/2022.03.28.486018 — microbiology — Posted on 2022-03-28
507 Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine
Kurhade, C.; Zou, j.; Xia, H.; Cai, H.; Yang, Q.; Cutler, M. W.; Cooper, D.; Muik, A.; Jansen, K.; Xie, X.; Swanson, K.; Shi, P.-Y.
10.1101/2022.03.24.485633 — microbiology — Posted on 2022-03-28
508 A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
Heuss, C.; Rothhaar, P.; Burm, R.; Lee, J.-Y.; Haselmann, U.; Ströh, L. J.; Ralfs, P.; Colasanti, O.; Tran, C. S.; Schäfer, N.; Schnitzler, P.; Merle, U.; Bartenschlager, R.; Patel, A. H.; Graw, F.; Krey, T.; Laketa, V.; Meuleman, P.; Lohmann, V.
10.1101/2022.03.28.486019 — microbiology — Posted on 2022-03-28
509 Genome-wide identification of the LexA-mediated DNA damage response in Streptomyces venezuelae
Stratton, K. J.; Bush, M. J.; Chandra, G.; Stevenson, C. E. M.; Findlay, K.; Schlimpert, S.
10.1101/2022.03.28.486056 — microbiology — Posted on 2022-03-28
510 Multiplexed measurement of binding- and neutralizing antibodies to SARS-CoV-2 variants in 12.000 post-vaccine sera
Tran, T. T.; Vaage, E. B.; Mehta, A.; Chopra, A.; Kolderup, A.; Anthi, A. K.; Konig, M.; Nygard, G.; Lind, A.; Muller, F.; Nissen-Meyer, L. S. H.; Magnus, P.; Trogstad, L.-I. S.; Mjaaland, S.; Soraas, A.; Midtvedt, K.; Aasberg, A.; Barratt-Due, A.; Medhus, A. W.; Hoivik, M. L.; Lundin, K. E. A.; Karlsen, R. F.; Dahle, R.; Danielsson, K.; Thomassen, K. S.; Birkeland Kro, G.; Cox, R. J.; Zhou, F.; Langeland, N.; Aukrust, P.; Melum, E.; Avitsland, T. L.; Wiencke, K.; Holter, J. C.; Munthe, L. A.; Grodeland, G.; Andersen, J. T.; Vaage, J. T.; Lund-Johansen, F.
10.1101/2022.03.26.484261 — immunology — Posted on 2022-03-28
511 CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80
Kennedy, A.; Robinson, M.; Hinze, C.; Waters, E.; Williams, C.; Halliday, N.; Dovedi, S.; Sansom, D.
10.1101/2022.03.28.486104 — immunology — Posted on 2022-03-28
516 Effectors from a Bacterial Vector-Borne Pathogen Exhibit Diverse Subcellular Localization, Expression Profiles and Manipulation of Plant Defense
Reyes Caldas, P.; Zhu, J.; Breakspear, A.; Thapa, S. P.; Toruno, T.; Perilla-Henao, L.; Casteel, C.; Faulkner, C.; Coaker, G.
10.1101/2021.09.10.459857 — plant biology — Posted on 2022-03-28
517 Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia - plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection
Quintana Alcala, J. F.; Chandrasegaran, P.; Sinton, M.; Briggs, E. M.; Otto, T. D.; Heslop, R.; Bentley-Abbot, C.; Loney, C.; de Lecea, L.; Mabbott, N. A.; MacLeod, A.
10.1101/2022.03.25.485502 — pathology — Posted on 2022-03-28
519 Integrative proteogenomics for differential expression and splicing variation in a DM1 mouse model
Solovyeva, E. M.; Utzinger, S.; Vissieres, A.; Mitchelmore, J.; Ahrne, E.; Hermes, E.; Poetsch, T.; Ronco, M.; Bidinosti, M.; Merkl, C.; Serluca, F.; Fessenden, J.; Naumann, U.; Voshol, H.; Meyer, A.; Hoersch, S.
10.1101/2021.05.15.443842 — genomics — Posted on 2022-03-28
520 A genomic assessment of the marine-speciation paradox within the toothed whale superfamily Delphinoidea
Westbury, M. V.; Cabrera, A. A.; Rey-Iglesia, A.; De Cahsan, B.; Duchene, D. A.; Hartmann, S.; Lorenzen, E. D.
10.1101/2020.10.23.352286 — evolutionary biology — Posted on 2022-03-28
523 Cell-intrinsic differences between human airway epithelial cells from children and adults
Maughan, E. F.; Hynds, R. E.; Pennycuick, A.; Nigro, E.; Gowers, K. H. C.; Denais, C.; Gomez-Lopez, S.; Lazarus, K. A.; Orr, J. C.; Pearce, D. R.; Clarke, S. E.; Lee, D. D. H.; Woodall, M. N. J.; Masonou, T.; Case, K.-M.; Teixeira, V. H.; Hartley, B. E.; Hewitt, R. J.; Al Yaghchi, C.; Sandhu, G. S.; Birchall, M. A.; O'Callaghan, C.; Smith, C. M.; De Coppi, P.; Butler, C. R.; Janes, S. M.
10.1101/2020.04.20.027144 — cell biology — Posted on 2022-03-28
524 Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection
Lawrence, A.-L. E.; Berger, R. P.; Hill, D. R.; Huang, S.; Yadagiri, V. K.; Bons, B.; Fields, C.; Sule, G. J.; Knight, J. S.; Wobus, C. E.; Spence, J.; Young, V.; O'Riordan, M. X.; Abuaita, B.
10.1101/2022.03.25.485742 — microbiology — Posted on 2022-03-28
525 Experience-Driven Rate Modulation is Reinstated During Hippocampal Replay
Tirole, M.; Huelin Gorriz, M.; Takigawa, M.; Kukovska, L.; Bendor, D.
10.1101/2021.07.15.452506 — neuroscience — Posted on 2022-03-28
526 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states
Kokaji, T.; Eto, M.; Hatano, A.; Yugi, K.; Morita, K.; Ohno, S.; Fujii, M.; Hironaka, K.-i.; Ito, Y.; Egami, R.; Uematsu, S. T.; Terakawa, A.; Pan, Y.; Maehara, H.; Li, D.; Bai, Y.; Tsuchiya, T.; Ozaki, H.; Inoue, H.; Kubota, H.; Suzuki, Y.; Hirayama, A.; Soga, T.; Kuroda, S.
10.1101/2022.03.27.486003 — systems biology — Posted on 2022-03-28
528 Planting graphene quantum dots in PEGylated nanoparticles for enhanced and multimodal in vivo imaging of tumor
Yan, H.; Wang, Q.; Wang, J.; Shang, W.; Xiong, Z.; Zhao, L.; Sun, X.; Tian, J.; Feng, S.-S.; Kang, F.
10.1101/2022.03.27.486000 — cancer biology — Posted on 2022-03-28
538 Phase-separated TRB-PRC2 aggregates contribute to Polycomb silencing in plants
Xuan, H.; Liu, Y.; Zhao, J.; Shi, N.; Li, Y.; Zhou, Y.; Pi, L.; Li, S.; Xu, G.; Yang, H.
10.1101/2022.03.27.485997 — plant biology — Posted on 2022-03-28
540 Extracellular vesicle fusion visualized by cryo-EM
Morandi, M. I.; Busko, P.; Ozer-Partuk, E.; Khan, S.; Zarfati, G.; Elbaz-Alon, Y.; Abou Karam, P.; Napso Shogan, T.; Ginini, L.; Gil, Z.; Regev-Rudzki, N.; Avinoam, O.
10.1101/2022.03.28.486013 — biophysics — Posted on 2022-03-28
541 Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR
Xu, J.; Chen, G.; Wang, H.; Cao, S.; Heng, J.; Deupi, X.; Du, Y.; Kobilka, B. K.
10.1101/2022.03.27.485993 — biophysics — Posted on 2022-03-28
543 Factors behind intraspecific competition during post-glacial recolonization: a Norway spruce case study
Tiret, M.; Olsson, L.; Grahn, T.; Karlsson, B.; Milesi, P.; Lascoux, M.; Lundqvist, S.-O.; Garcia-Gil, M. R.
10.1101/2022.01.15.476468 — evolutionary biology — Posted on 2022-03-28
546 Broad neutralization of SARS-CoV-2 variants by circular mRNA producing VFLIP-X spike in mice
Seephetdee, C.; Bhukhai, K.; Buasri, N.; Leelukkanaveera, P.; Lerdwattanasombat, P.; Manopwisedjaroen, S.; Phueakphud, N.; Kuhaudomlarp, S.; Olmedillas, E.; Ollmann Saphire, E.; Thitithanyanont, A.; Hongeng, S.; Wongtrakoongate, P.
10.1101/2022.03.17.484759 — immunology — Posted on 2022-03-28
548 SCExecute: cell barcode-stratified analyses of scRNA-seq data
Edwards, N. J.; Dillard, C.; NM, P.; Liu, H.; Yang, M.; Ulianova, E.; Horvath, A.
10.1101/2022.03.27.485988 — genomics — Posted on 2022-03-28
549 Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Johnson, B. A.; Zhou, Y.; Lokugamage, K. G.; Vu, M. N.; Bopp, N. E.; Crocquet-Valdes, P. A.; Kalveram, B.; Schindewolf, C.; Liu, Y.; Scharton, D.; Plante, J. A.; Xie, X.; Aguilar, P.; Weaver, S.; Shi, P.-Y.; Walker, D. H.; Routh, A. L.; Plante, K.; Menachery, V. D.
10.1101/2021.10.14.464390 — microbiology — Posted on 2022-03-28
551 A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells
Chen, W. C. W.; Gaidukov, L.; Lai, Y.; Wu, M.-R.; Cao, J.; Gutbrod, M. J.; Choi, G. C. G.; Utomo, R. P.; Chen, Y.-C.; Wroblewska, L.; Kellis, M.; Zhang, L.; Weiss, R.; Lu, T. K.
10.1101/2020.12.11.420000 — synthetic biology — Posted on 2022-03-28
553 The costs of global protected-area expansion (Target 3 of the post-2020 Global Biodiversity Framework) may fall more heavily on lower-income countries
Waldron, A.; Besancon, C.; Watson, J. E.; Adams, V. M.; Sumaila, U. R.; Garnett, S.; Balmford, A.; Butchart, S. H. M.
10.1101/2022.03.23.485429 — ecology — Posted on 2022-03-28
557 Quantifying cerebral blood arrival times using hypoxia-mediated arterial BOLD contrast
Bhogal, A. A.; Sayin, E. S.; Poublanc, J.; Duffin, J.; Fisher, J. A.; Mikulis, D. J.; Sobcyzk, O.
10.1101/2022.03.27.485933 — neuroscience — Posted on 2022-03-28
558 The basolateral amygdala to lateral septum circuit is critical for regulating sociability in mice
Rodriguez, L. A.; Kim, S.-H.; Page, S. C.; Nguyen, C. V.; Pattie, E. A.; Hallock, H. L.; Valerino, J.; Maynard, K.; Jaffe, A. E.; Martinowich, K.
10.1101/2021.10.21.464669 — neuroscience — Posted on 2022-03-28
560 4-aminopyridine promotes accelerated skin wound healing via neurogenic-mediator expression
Mashanipalya Guddadarangaiah, J.; Govindappa, P. K.; Nelson, A. M.; Noble, M. D.; Elfar, J.
10.1101/2021.10.31.465317 — neuroscience — Posted on 2022-03-28
561 Horizontal connectivity in V1 : Prediction of coherence in contour and motion integration
Fregnac, Y.; Le Bec, B.; Troncoso, X. G.; Desbois, C.; Passarelli, Y.; Baudot, P.; Monier, C.; Pananceau, M.
10.1101/2021.09.10.459746 — neuroscience — Posted on 2022-03-28
563 Interactions between anthropogenic stressors and recurring perturbations mediate ecosystem resilience or collapse
Keith, D. A.; Benson, D. H.; Baird, I. R. C.; Watts, L.; Simpson, C. C.; Krogh, M.; Gorissen, S.; Ferrer-Paris, J. R.; Mason, T. J.
10.1101/2022.03.27.485937 — ecology — Posted on 2022-03-28
566 Metacells untangle large and complex single-cell transcriptome networks
Bilous, M.; Tran, L.; Cianciaruso, C.; Gabriel, A.; Michel, H.; Carmona, S. J.; Pittet, M. J.; Gfeller, D.
10.1101/2021.06.07.447430 — bioinformatics — Posted on 2022-03-28
567 Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders
Dieudonne, T.; Herrera, S. A.; Laursen, M. J.; Lejeune, M.; Stock, C.; Slimani, K.; Jaxel, C.; Lyons, J. A.; Montigny, C.; Pomorski, T. G.; Nissen, P.; Lenoir, G.
10.1101/2021.11.03.467174 — biochemistry — Posted on 2022-03-28
568 Integrated data-driven reannotation of the Kluyveromyces marxianus genome reveals an expanded protein coding repertoire
Fenton, D. A.; Swirski, M.; O'Connor, P. B.; Kiniry, S. J.; Michel, A. M.; Kufel, J.; Baranov, P. V.; Morrissey, J. P.
10.1101/2022.03.25.485750 — genomics — Posted on 2022-03-28
574 Knockout of TSPO delays and reduces amyloid, Tau, astrocytosis and behavioral dysfunctions in Alzheimer's disease.
Ceyzeriat, K.; Meyer, L.; Bouteldja, F.; Tsartsalis, S.; Amosse, Q.; Middleton, R. J.; Liu, G.-J.; Banati, R. B.; Zilli, T.; Garibotto, V.; Millet, P.; Tournier, B. B.
10.1101/2022.03.26.485919 — pathology — Posted on 2022-03-28
575 Dynamic Flux Balance Analysis Models in SBML
König, M.; Watanabe, L. H.; Grzegorzewski, J.; Myers, C. J.
10.1101/245076 — bioinformatics — Posted on 2022-03-28
578 Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
Stolz, V.; Rica, R.; Zhu, C.; Preglej, T.; Hamminger, P.; Hainberger, D.; Alteneder, M.; Müller, L.; Waltenberger, D.; Hladik, A.; Agerer, B.; Schuster, M.; Frey, T.; Krausgruber, T.; Boucheron, N.; Knapp, S.; Schmetterer, K.; Trauner, M.; Bergthaler, A.; Bock, C.; Ellmeier, W.
10.1101/2022.03.24.485609 — immunology — Posted on 2022-03-28
579 A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors
Wang, H.; Qian, T.; Zhao, Y.; Zhuo, Y.; Wu, C.; Osakada, T.; Chen, P.; Ren, H.; Yan, Y.; Geng, L.; Fu, S.; Mei, L.; Li, G.; Wu, L.; Jiang, Y.; Qian, W.; Peng, W.; Xu, M.; Hu, J.; Chen, L.; Tang, C.; Lin, D.; Zhou, J.-N.; Li, Y.
10.1101/2022.03.26.485911 — neuroscience — Posted on 2022-03-28
580 Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia
George, A.; Farrell, J. S.; Colangeli, R.; Wall, A. K.; Gom, R. C.; Kesler, M. T.; de la Hoz, C. L.; Perera, T.; Rho, J. M.; Kurrasch, D.; Teskey, G. C.
10.1101/2022.03.25.485818 — neuroscience — Posted on 2022-03-28
581 Altered M2 Cortex - Superior Colliculus visual perception circuit in Huntington's Disease
Conde-Berriozabal, S.; Garcia-Gilabert, L.; Garcia-Garcia, E.; Sitja-Roqueta, L.; Lopez-Gil, J.; Munoz-Moreno, E.; Boutagouga Boudjadja, M.; Soria, G.; Rodriguez, M. J.; Alberch, J.; Masana, M.
10.1101/2022.03.24.485610 — neuroscience — Posted on 2022-03-28
583 Tree species and genetic diversity increase productivity via functional diversity and trophic feedbacks
Tang, T.; Zhang, N.; Bongers, F. J.; Staab, M.; Schuldt, A.; Fornoff, F.; Lin, H.; Cavender-Bares, J.; Hipp, A. L.; Li, S.; Liang, Y.; Han, B.; Klein, A.-M.; Bruelheide, H.; Durka, W.; Schmid, B.; Ma, K.; Liu, X.
10.1101/2022.03.25.485785 — ecology — Posted on 2022-03-28
584 The Human Motoneuron Expression Signature is Defined by ALS-Related Genes
Yadav, A.; Matson, K. J. E.; Li, L.; Hua, I.; Gaur, P.; Alkaslasi, M. R.; Hasan, S.; Galuta, A.; Dedek, A.; Ameri, S.; Parnell, J.; Alshardan, M. M.; Ququmji, F. A.; Alhamad, S. M.; Wang, A. P.; Poulen, G.; Lonjon, N.; Vachiery-Lahaye, F.; Nalls, M. A.; Nalls, M. A.; Qi, Y. A.; Hildebrand, M. E.; Mery, P.-F.; Bourinet, E.; Bauchet, L.; Tsai, E. C.; Ward, M. E.; Le Pichon, C.; Menon, V.; Levine, A.
10.1101/2022.03.25.485808 — neuroscience — Posted on 2022-03-28
585 High temperature increases centromere-mediated genome elimination frequency in Arabidopsis deficient in cenH3 or its assembly factor KNL2
Ahmadli, U.; Kalidass, M.; Khaitova, L. C.; Fuchs, J.; Cuacos, M.; Demidov, D.; Zuo, S.; Pecinkova, J.; Ingouff, M.; Mascher, M.; Heckmann, S.; Houben, A.; Riha, K.; Lermontova, I.
10.1101/2022.03.24.485459 — plant biology — Posted on 2022-03-28
586 The dynamics of adaptation to stress from standing genetic variation and de novo mutations
Ament-Velasquez, S. L.; Gilchrist, C.; Rego, A.; Bendixsen, D. P.; Brice, C.; Grosse-Sommer, J. M.; Rafati, N.; Stelkens, R.
10.1101/2022.03.26.485920 — evolutionary biology — Posted on 2022-03-28
587 DNA Methylation Dynamics and Dysregulation Delineated by High-Throughput Profiling in the Mouse
Zhou, W.; Hinoue, T.; Barnes, B.; Mitchell, O.; Iqbal, W.; Lee, S. M.; Foy, K. K.; Lee, K.-H.; Moyer, E. J.; VanderArk, A.; Koeman, J. M.; Ding, W.; Kalkat, M.; Spix, N. J.; Eagleson, B.; Pospisilik, J. A.; Szabo, P. E.; Bartolomei, M. S.; Schaaf, N. A. V.; Kang, L.; Wiseman, A. K.; Jones, P. A.; Krawczyk, C. M.; Adams, M.; Porecha, R.; Chen, B. H.; Shen, H.; Laird, P. W.
10.1101/2022.03.24.485667 — genomics — Posted on 2022-03-27
592 Knockout of TSPO delays and reduces amyloid, Tau, astrocytosis and behavioral dysfunctions in Alzheimer's disease.
Ceyzeriat, K.; Meyer, L.; Bouteldja, F.; Tsartsalis, S.; Amosse, Q.; Middleton, R. J.; Liu, G.-J.; Banati, R. B.; Zilli, T.; Garibotto, V.; Millet, P.; Tournier, B. B.
10.1101/2022.03.26.485919 — pathology — Posted on 2022-03-27
595 Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data
Andreani, T.; Slot, L.; Gabillard, S.; Struebing, C.; Reimertz, C.; Veeranagouda, Y.; Bakker, A.; Olfati-Saber, R.; Toes, R. E. M.; Auge, F.; Simaite, D.
10.1101/2022.03.24.485600 — bioinformatics — Posted on 2022-03-27
597 Ovipin: a chicken eggs antibiotic agent
dos Santos, S. R.; Miranda, A.; Silva Junior, P. I.
10.1101/2021.09.28.462162 — microbiology — Posted on 2022-03-27
602 Multicellular Reservoir Computing
Nikolic, V.; Echlin, M.; Aguilar, B.; Shmulevich, I.
10.1101/2022.03.26.485905 — systems biology — Posted on 2022-03-27
604 The role of repetitive DNA in re-patterning of major rDNA clusters in Lepidoptera
Dalikova, M.; Provaznikova, I.; Provaznik, J.; Grof-Tisza, P.; Pepi, A.; Nguyen, P.
10.1101/2022.03.26.485928 — genomics — Posted on 2022-03-27
608 Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices
Chen, D.; Du, Y.; Llewellyn, J.; Bonna, A.; Zuo, B.; Janmey, P. A.; Farndale, R. W.; Wells, R. G.
10.1101/2022.03.27.485990 — cell biology — Posted on 2022-03-27
610 S51 family peptidases provide resistance to peptidyl-nucleotide antibiotic McC
Yagmurov, E.; Gilep, K.; Serebryakova, M.; Wolf, Y. I.; Dubiley, S.; Severinov, K. V.
10.1101/2022.03.27.485901 — microbiology — Posted on 2022-03-27
611 A Bayesian approach to incorporate structural data into the mapping of genotype to antigenic phenotype of influenza A(H3N2) viruses
Harvey, W. T.; Davies, V.; Daniels, R. S.; Whittaker, L.; Gregory, V.; Hay, A. J.; Husmeier, D.; McCauley, J. W.; Reeve, R.
10.1101/2022.03.26.485931 — microbiology — Posted on 2022-03-27
612 Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism
D'Ignazio, L.; Jacomini, R. S.; Qamar, B.; Benjamin, K. J. M.; Arora, R.; Sawada, T.; Evans, T. A.; Diffenerfer, K. E.; Pankonin, A. R.; Hendriks, W. T.; Hyde, T. M.; Kleinman, J. E.; Weinberger, D.; Bragg, D. C.; Paquola, A. C.; Erwin, J. A.
10.1101/2022.03.26.485862 — neuroscience — Posted on 2022-03-27
613 T cells induce interferon-responsive oligodendrocytes during white matter aging
Kaya, T.; Mattugini, N.; Liu, L.; Ji, H.; Besson-Girard, S.; Kaji, S.; Liesz, A.; Gokce, O.; Simons, M.
10.1101/2022.03.26.485917 — neuroscience — Posted on 2022-03-27
614 CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons
Wu, G.-H.; Smith-Geater, C.; Galaz-Montoya, J. G.; Gu, Y.; Gupte, S. R.; Aviner, R.; Mitchell, P. G.; Hsu, J.; Miramontes, R.; Wang, K. Q.; Geller, N.; Danita, C.; Joubert, L.-M.; Schmid, M. F.; Yeung, S.; Frydman, J.; Mobley, W.; Wu, C.; Thompson, L. M.; Chiu, W.
10.1101/2022.03.26.485912 — neuroscience — Posted on 2022-03-27
618 The aggregation potential of Zika virus proteome
Giri, R.; Bhardwaj, T.; Saumya, K. U.; Gadhave, K.; Kapuganti, S. K.; Sharma, N.
10.1101/2022.03.26.485915 — biophysics — Posted on 2022-03-27
621 Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes
Diebold, O.; Gonzalez, V.; Venditti, L.; Sharp, C.; Blake, R. A.; Stevens, J.; Caddy, S.; Digard, P.; Borodavka, A.; Gaunt, E.
10.1101/2022.03.23.485570 — microbiology — Posted on 2022-03-27
622 Optimized production and fluorescent labelling of SARS-CoV-2 Virus-Like-Particles to study virus assembly and entry.
Muriaux, D.; Gourdelier, M.; Swain, J. M.; Arone, C.; Mouttou, A.; Bracquemond, D.; Merida, P.; Saffarian, S.; Lyonnais, S.; Favard, C.
10.1101/2022.03.23.485575 — microbiology — Posted on 2022-03-27
625 Environmental predictors of electroactive bacterioplankton in small boreal lakes.
Olmsted, C. N.; Ort, R.; Tran, P. Q.; McDaniel, E. A.; Roden, E. E.; Bond, D. R.; He, S.; McMahon, K. D.
10.1101/2022.03.26.485925 — microbiology — Posted on 2022-03-27
626 UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
Black, H. H.; Roberts, J. E.; Leslie, S. N.; Campodonico, W.; Ebmeier, C. C.; Lau, C. I.; Whiteley, A. M.
10.1101/2022.03.25.485837 — cell biology — Posted on 2022-03-27
627 Petascale pipeline for precise alignment of images from serial section electron microscopy
Popovych, S.; Macrina, T.; Kemnitz, N.; Castro, M. A.; Nehoran, B.; Jia, Z.; Bae, J. A.; Mitchell, E.; Mu, S.; Trautman, E. T.; Saalfeld, S.; Li, K.; Seung, H. S.
10.1101/2022.03.25.485816 — neuroscience — Posted on 2022-03-27
630 Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential
Carlessi, R.; Denisenko, E.; Boslem, E.; Koehn-Gaone, J.; Main, N.; Bakar, N. D. B. A.; Shirolkar, G. D.; Jones, M.; Poppe, D.; Dwyer, B. J.; Jackaman, C.; Tjiam, M. C.; Lister, R.; Karin, M.; Fallowfield, J. A.; Kendall, T. J.; Forbes, S. J.; Olynyk, J. K.; Yeoh, G.; Forrest, A. R. R.; Ramm, G. A.; Febbraio, M. A.; Tirnitz-Parker, J. E. E.
10.1101/2022.03.25.485695 — cancer biology — Posted on 2022-03-27
631 BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockade
Olson, B.; Chaudagar, K.; Bao, R.; Sharma-Saha, S.; Hong, C.; Rameshbabu, S.; Chen, R.; Thomas, A.; Patnaik, A.
10.1101/2022.03.24.485685 — cancer biology — Posted on 2022-03-27
633 Multiplexed microfluidic chip for cell co-culture
Watson, C.; Liu, C.; Ansari, A.; Miranda, H. C.; Somoza, R. A.; Senyo, S. E.
10.1101/2022.03.25.485382 — bioengineering — Posted on 2022-03-27
634 Mobile elements in human population-specific genome and phenotype divergence
Kojima, S.; Koyama, S.; Ka, M.; Saito, Y.; Parrish, E. H.; Endo, M.; Takata, S.; Mizukoshi, M.; Hikino, K.; Takeda, A.; Gelinas, A. F.; Heaton, S. M.; Koide, R.; Kamada, A. J.; Noguchi, M.; Hamada, M.; Biobank Japan Project Consortium, ; Kamatani, Y.; Murakawa, Y.; Ishigaki, K.; Nakamura, Y.; Ito, K.; Terao, C.; Momozawa, Y.; Parrish, N. F.
10.1101/2022.03.25.485726 — genetics — Posted on 2022-03-27
635 Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae
Alfatah, M.; Cui, L.; Goh, C. J. H.; Wong, J. H.; Lewis, J.; Poh, W. J.; Arumugam, P.
10.1101/2022.03.25.485766 — genetics — Posted on 2022-03-27
636 Footprints of domestication in dry-cured meat Penicillium fungi: convergent specific phenotypes and horizontal gene transfers
Lo, Y.-C.; Bruxaux, J.; Rodriguez de la Vega, R. C.; Snirc, A.; Coton, M.; Le Piver, M.; Le Prieur, S.; Roueyre, D.; Dupont, J.; Houbraken, J.; Debuchy, R.; Ropars, J.; Giraud, T.; Branca, A.
10.1101/2022.03.25.485132 — evolutionary biology — Posted on 2022-03-27
637 Strategies for sampling pseudo-absences for species distribution models in complex mountainous terrain
Descombes, P.; Chauvier, Y.; Brun, P.; Righetti, D.; Wuest, R. O.; Karger, D. N.; Zurell, D.; Zimmermann, N. E.
10.1101/2022.03.24.485693 — ecology — Posted on 2022-03-27
639 siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos
Masuda-Ozawa, T.; Fujita, S.; Nakamura, R.; Watanabe, H.; Kuranaga, E.; Nakajima, Y.-i.
10.1101/2022.03.24.485716 — developmental biology — Posted on 2022-03-27
641 Effects of variability in manually contoured spinal cord masks on fMRI co-registration and interpretation
Hoggarth, M. A.; Wang, M. C.; Hemmerling, K. J.; Vigotsky, A. D.; Smith, Z. A.; Parrish, T. B.; Weber, K. A.; Bright, M. G.
10.1101/2022.03.25.485810 — neuroscience — Posted on 2022-03-27
644 ALS sensitive spinal motor neurons enter a degenerative downward spiral of impaired splicing and proteostasis
Iannitelli, D.; Tan, A.; Nguyen, E.; Babu, A.; Elorza, S.; Joseph, T.; Zaaijer, S.; Ward, m.; Mazzoni, E. O.
10.1101/2022.03.26.485939 — neuroscience — Posted on 2022-03-27
645 An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics
Shaver, A. O.; Garcia, B. M.; Gouveia, G. J.; Morse, A. M.; Liu, Z.; Borges, R. M.; Asef, C. K.; Leach, F. E.; Andersen, E. C.; Amster, I. J.; Fernandez, F. M.; Edison, A. S.; McIntyre, L. M.
10.1101/2022.03.25.485859 — systems biology — Posted on 2022-03-27
646 Digital twins and hybrid modelling for simulation of physiological variables and stroke risk
Herrgardh, T.; Hunter, E.; Tunedal, K.; Orman, H.; Amann, J.; Navarro, F. A.; Martinez-Costa, C.; Kelleher, J. D.; Cedersund, G.
10.1101/2022.03.25.485803 — systems biology — Posted on 2022-03-27
651 A cancer stem cell population underlies a multi-lineage phenotype and drug resistance in prostate cancer
Beshiri, M. L.; Capaldo, B. J.; Lake, R.; Ku, A. T.; Burner, D.; Tice, C. M.; Tran, C.; Kostas, J.; Alilin, A. N.; Yin, J.; Agarwal, S.; Morris, S. A.; Karzai, F. H.; Lotan, T. L.; Dahut, W. L.; Sowalsky, A. G.; Kelly, K.
10.1101/2022.03.24.484651 — cancer biology — Posted on 2022-03-27
652 CHA1: A New Combinatorial Therapy That Reciprocally Regulates Wnt and JAK/STAT/Interferon Signaling to Re-program Breast Tumors and the Tumor-Resident Landscape.
Alamoudi, M. K.; Chipman, M. E.; Deleso-Frechette, F. H.; Bogis, A. M.; Alqurashi, R. S.; Li, K.; Zhang, R.; Castañer, M.; Triantafillou, G.; Herbosa, C. G.; Carland, C.; Lee, A. J.; Gillani, K. S.; Paulson, K. E.; Yee, A. S.
10.1101/2022.03.25.485706 — cancer biology — Posted on 2022-03-27
653 Adversary of DNA integrity: a long non-coding RNA stimulates driver oncogenic chromosomal rearrangement in human thyroid cells
Demin, D. E.; Murashko, M. M.; Uvarova, A. N.; Stasevich, E. M.; Shyrokova, E. Y.; Gorlachev, G. E.; Korneev, K. V.; Ustiugova, A. S.; Tkachenko, E. A.; Kostenko, V. V.; Tatosyan, K. A.; Sheetikov, S. A.; Spirin, P. V.; Kuprash, D. V.; Schwartz, A. M.
10.1101/2022.03.25.485761 — cancer biology — Posted on 2022-03-27
654 Targeting tumor stemness switch phenotype by activating pathogen induced stem cell niche defense
Das, B.; Bhuyan, S.; Pal, B.; Pathak, L.; Saikia, P. J.; Mitra, S.; Gayan, S.; Mokhtari, R. B.; Li, H.; Ramana, C. V.; Baishya, D.
10.1101/2022.03.25.485829 — cancer biology — Posted on 2022-03-27
661 Structure of the connexin-43 gap junction channel reveals a closed sieve-like molecular gate
Qi, C.; Acosta-Gutierrez, S.; Lavriha, P.; Othman, A.; Lopez-Pigozzi, D.; Bayraktar, E.; Schuster, D.; Picotti, P.; Zamboni, N.; Bortolozzi, M.; Gervasio, F. L.; Korkhov, V. M.
10.1101/2022.03.26.485947 — biochemistry — Posted on 2022-03-27
664 Genome-wide signatures of geographic expansion and breeding process in soybean
Li, Y.-h.; Qin, C.; Wang, L.; Jiao, C.; Hong, H.; Tian, Y.; Li, Y.; Xing, G.; Wang, J.; Gu, Y.; Gao, X.; Li, D.; Li, H.; Liu, Z.; Jing, X.; Feng, B.; Zhao, T.; Guan, R.; Guo, Y.; Liu, J.; Yan, Z.; Zhang, L.; Ge, T.; Li, X.; Wang, X.; Qiu, H.; Zhang, W.; Luan, X.; Han, Y.; Han, D.; Chang, R.; Guo, Y.; Reif, J. C.; Jackson, S. A.; Liu, B.; Tian, S.; Qiu, L.-J.
10.1101/2022.03.24.485586 — genomics — Posted on 2022-03-27
668 Novel Methods for Multi-ancestry Polygenic Prediction and their Evaluations in 3.7 Million Individuals of Diverse Ancestry
Zhang, H.; Zhan, J.; Jin, J.; Ahearn, T. U.; Yu, Z.; O'Connell, J.; Jiang, Y.; Chen, T.; 23andMe Research Team, ; Garcia-Closas, M.; Lin, X.; Koelsch, B. L.; Chatterjee, N.
10.1101/2022.03.24.485519 — genetics — Posted on 2022-03-27
670 Utilisation of Oxford Nanopore sequencing to generate six complete gastropod mitochondrial genomes as part of a biodiversity curriculum
De Vivo, M.; Lee, H.-H.; Huang, Y.-H.; Drever, N.; Fong, C.-l.; de Mattos, F. M. G.; Jain, D.; Wen, Y.-H. V.; Mwihaki, J. K.; Wang, T.-Y.; Machida, R. J.; Wang, J.; Chan, B. K. K.; Tsai, I. J.
10.1101/2022.03.24.485721 — ecology — Posted on 2022-03-27
675 Exosomally targeting microRNA23a ameliorates microvascular endothelial barrier dysfunction following rickettsial infection
Zhou, C.; Bei, J.; Qiu, Y.; Chang, Q.; Nyong, E.; Yang, J.; Krishnan, B.; Khanipov, K.; Jin, Y.; Fang, X.; Gaitas, A.; Gong, B.
10.1101/2022.03.25.485825 — cell biology — Posted on 2022-03-27
676 Phase Separation of a Nodulin Sec14-like protein Maintains Auxin Efflux Carrier Polarity at Arabidopsis Plasma Membranes
Liu, C.; Mentzelopoulou, A.; Deli, A.; Papagavriil, F.; Ramachandran, P.; Perraki, A.; Claus, L.; Barg, S.; Doermann, P.; Jaillais, Y.; Johnen, P.; Russinova, E.; Gizeli, E.; Schaaf, G.; Moschou, P. N.
10.1101/2022.03.26.485938 — cell biology — Posted on 2022-03-27
677 A gut commensal protozoa remotely shapes a lung niche for asthma-promoting eosinophils.
Burrows, K.; Ngai, L.; Chiaranunt, P.; Cao, E.; Streutker, C.; Forde, B.; O'Mahony, L.; Mortha, A.
10.1101/2022.03.25.485893 — immunology — Posted on 2022-03-27
679 Rapid differentiation of regulatory CD4+ T cells in the infarcted myocardium blunts in situ inflammation
Delgobo, M.; Weiss, E.; Ashour, D. E.; Popiolkowski, L.; Arampatzi, P.; Stangl, V.; Arias-Loza, P.; Rainer, P.; Saliba, A.-E.; Ludewig, B.; Hofmann, U.; Frantz, S.; Ramos, G. C.
10.1101/2022.03.25.485791 — immunology — Posted on 2022-03-27
680 TNFR2 costimulation differentially impacts regulatory and conventional CD4+ T-cell metabolism
Mensink, M.; Zaal, E. A.; Tran Ngoc Minh, T.; Schrama, E.; Berkers, C. R.; Borst, J.; de Kivit, S.
10.1101/2022.03.25.485786 — immunology — Posted on 2022-03-27
683 Enhanced short-wavelength sensitivity in the blue-tongued skink,Tiliqua rugosa
Nagloo, N.; Mountford, J.; Gundry, B. J.; Hart, N. S.; Davies, W. I. L.; Collin, S. P.; Hemmi, J. M.
10.1101/2022.03.25.485754 — neuroscience — Posted on 2022-03-27
684 Single-cell Transcriptomic Atlas of the Human Substantia Nigra in Parkinson's Disease
Wang, Q.; Wang, M.; Choi, I.; Ho, L.; Farrell, K.; Beaumont, K. G.; Sebra, R.; Crary, J. F.; Davis, D. A.; Sun, X.; Zhang, B.; Yue, Z.
10.1101/2022.03.25.485846 — neuroscience — Posted on 2022-03-27
687 Microglial TNFα orchestrates brain phosphorylation during the sleep period and controls homeostatic sleep.
Pinto, M. J.; Cottin, L.; Dingli, F.; Laigle, V.; Ribeiro, L. F.; Triller, A.; Henderson, F.; Loew, D.; Fabre, V.; Bessis, A.
10.1101/2022.03.24.485623 — neuroscience — Posted on 2022-03-27
690 A Spinal Circuit That Transmits Innocuous Cool Sensations
Horwitz, L. R.; Lee, H.; Hor, C. C.; Shen, F. Y.; Cai, W.; Li, C.; Pai, E. L.-L.; Fung, T. L. R.; Rovcanin, I.; Pipe, K. P.; Xu, X. Z. S.; Cai, D.; Duan, B.
10.1101/2022.03.23.485555 — neuroscience — Posted on 2022-03-27
691 Synthetic torpor triggers a neuroprotective and regulated mechanism in the rat brain, leading to the reversibility of Tau protein hyperphosphorylation.
Squarcio, F.; Hitrec, T.; Piscitiello, E.; Cerri, M.; Giovannini, C.; Martelli, D.; Occhinegro, A.; Taddei, L.; Tupone, D.; Amici, R.; Luppi, M.
10.1101/2022.03.25.485745 — neuroscience — Posted on 2022-03-27
696 Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction.
Tapella, L.; Dematteis, G.; Moro, M.; Pistolato, B.; Tonelli, E.; Vanella, V. V.; Giustina, D.; La Forgia, A.; Restelli, E.; Barberis, E.; Villani, S.; Del Grosso, E.; Grilli, M.; Manfredi, M.; Corazzari, M.; Grolla, A. A.; Genazzani, A. A.; Lim, D.
10.1101/2022.03.24.485644 — neuroscience — Posted on 2022-03-27
698 Multi-omics Analysis of Dsup Expressing Human Cells Reveals Open Chromatin Architectural Dynamics Underyling Radioprotection
Westover, C.; Najjar, D.; Meydan, C.; Grigorev, K.; Veling, M. T.; Chang, R. L.; Chin, C.; Butler, D.; Afshin, E. E.; Silver, P.; Mason, C.
10.1101/2020.11.10.373571 — synthetic biology — Posted on 2022-03-27
700 Polymer nanoparticles pass the plant interface
Parkinson, S. J.; Tungsirisurp, S.; Sikder, A.; Lynch, I.; O'Reilly, R. K.; Napier, R. M.
10.1101/2022.03.24.485656 — plant biology — Posted on 2022-03-27
702 Establishing a reproducible approach for the controllable deposition and maintenance of plants cells with 3D bioprinting
Van den Broeck, L.; Schwartz, M. F.; Krishnamoorthy, S.; Spurney, R. J.; Abderamane Tahir, M.; Melvin, C.; Gobble, M.; Peters, R.; Muhammad, A.; Li, B.; Stuiver, M.; Horn, T.; Sozzani, R.
10.1101/2022.03.25.485804 — plant biology — Posted on 2022-03-27
703 Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice
Xie, K.; Fuchs, H.; Scifo, E.; Liu, D.; Aziz, A.; Aguilar- Pimentel, J. A.; Amarie, O. V.; Becker, L.; da Silva-Buttkus, P.; Calzada-Wack, J.; Cho, Y.-L.; Deng, Y.; Edwards, A. C.; Garrett, L.; Georgopoulou, C.; Gerlini, R.; Hoelter, S. M.; Klein-Rodewald, T.; Kramer, M.; Leuchtenberger, S.; Lountzi, D.; Mayer-Kuckuk, P.; Nover, L. L.; Oestereicher, M. A.; Overkott, C.; Pearson, B. L.; Rathkolb, B.; Rozman, J.; Russ, J.; Schaaf, K.; Spielmann, N.; Sanz-Moreno, A.; Stoeger, C.; Treise, I.; Bano, D.; Busch, D. H.; Graw, J.; Klingenspor, M.; Klopstock, T.; Mock, B. A.; Salomoni, P.; Schmidt-Weber
10.1101/2022.03.25.485824 — physiology — Posted on 2022-03-27
704 Leaf nitrogen does not explain changes in soybean radiation-use efficiency in vegetative and early reproductive stages
Cafaro La Menza, N.; Arkebauer, T. J.; Lindquist, J. L.; Monzon, J. P.; Knops, J. M. H.; Graef, G.; Scoby, D.; Howard, R.; Rees, J.; Specht, J. E.; Grassini, P.
10.1101/2022.03.24.485711 — physiology — Posted on 2022-03-27
705 Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia - plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection
Quintana Alcala, J. F.; Chandrasegaran, P.; Sinton, M.; Briggs, E. M.; Otto, T. D.; Heslop, R.; Bentley-Abbot, C.; Loney, C.; de Lecea, L.; Mabbott, N. A.; MacLeod, A.
10.1101/2022.03.25.485502 — pathology — Posted on 2022-03-27
706 LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer
Delle Cave, D.; Buonaiuto, S.; Mangini, M.; Sainz, B.; Di Domenico, A.; Teresa Iavazzo, T.; Andolfi, G.; Cortina Duran, C.; Sevillano, M.; Heeschen, C.; Colonna, V.; Corona, M.; Cucciardi, A.; Di Guida, M.; Batlle, E.; De Luca, A.; Lonardo, E.
10.1101/2022.03.24.485651 — cancer biology — Posted on 2022-03-27
707 S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
Amar-Schwartz, A.; Ben Hur, V.; Jbara, A.; Cohen, Y.; Barnabas, G. D.; Siegfried, Z.; Mashahreh, B.; Hassouna, F.; Shilo, A.; Abu-Odeh, M.; Berger, M.; Wiener, R.; Aqeilan, R. I.; Geiger, T.; Karni, R.
10.1101/2022.03.25.485744 — cancer biology — Posted on 2022-03-27
708 CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer
Mou, H.; Yue, J.; Jin, Y.; Wang, Z.; Gao, Y.; Janowitz, T.; Meyer, H. V.; Kucukural, A.; Wilkinson, J. E.; Ozata, D. M.; Beyaz, S.
10.1101/2022.03.27.485965 — cancer biology — Posted on 2022-03-27
709 AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment
Lorenz, N. I.; Sauer, B.; Zeiner, P. S.; Strecker, M. I.; Luger, A.-L.; Schulte, D.; Mittelbronn, M.; Alekseeva, T.; Sevenich, L.; Harter, P. N.; Münch, C.; Steinbach, J. P.; Ronellenfitsch, M. W.
10.1101/2022.03.25.485624 — cancer biology — Posted on 2022-03-27
710 NADK upregulation is an essential metabolic adaptation that enables breast cancer metastatic colonization
Ilter, D.; Schild, T.; Ward, N.; Drapela, S.; Adhikari, E.; Low, V.; Le-Lau, E.; DeNicola, G. M.; McReynolds, M.; Gomes, A. P.
10.1101/2022.03.25.485887 — cancer biology — Posted on 2022-03-27
714 PPML-Omics: a Privacy-Preserving federated Machine Learning system protects patients' privacy from omic data
Zhou, J.; Chen, S.; Wu, Y.; Li, H.; Zhang, B.; Zhou, L.; Hu, Y.; Xiang, Z.; Li, Z.; Chen, N.; Han, W.; Wang, D.; Gao, X.
10.1101/2022.03.23.485485 — bioinformatics — Posted on 2022-03-27
715 SIEVE: joint inference of single-nucleotide variants and cell phylogeny from single-cell DNA sequencing data
Kang, S.; Borgsmüller, N.; Valecha, M.; Kuipers, J.; Alves, J.; Prado-Lopez, S.; Chantada, D.; Beerenwinkel, N.; Posada, D.; Szczurek, E.
10.1101/2022.03.24.485657 — bioinformatics — Posted on 2022-03-27
721 Treatment with an Antigen-Specific Dual Microparticle System Reverses Advanced Multiple Sclerosis in Mice
Kwiatkowski, A. J.; Helm, E. Y.; Stewart, J. M.; Drashansky, T. T.; Cho, J. J.; Avram, D.; Keselowsky, B. G.
10.1101/2022.03.25.485841 — bioengineering — Posted on 2022-03-27
722 Modulation of RNA binding properties of the RNA helicase UPF1 by its activator UPF2
Xue, G.; Maciej, V. D.; Machado de Amorim, A.; Pak, M.; Jayachandran, U.; Chakrabarti, S.
10.1101/2022.03.26.485946 — biochemistry — Posted on 2022-03-27
726 Discordant genotype calls across technology platforms elucidate variants with systematic errors in next-generation sequencing
Atkinson, E. G.; Artomov, M.; Karczewski, K. J.; Loboda, A. A.; Rehm, H. L.; MacArthur, D. G.; Neale, B. M.; Daly, M. J.
10.1101/2022.03.24.485707 — genomics — Posted on 2022-03-27
729 circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner
Josipovic, N.; Ebbessen, K. K.; Zirkel, A.; Mackay-Danieli, A.; Dieterich, C.; Kurian, L.; Hansen, T. B.; Papantonis, A.
10.1101/2022.03.25.485787 — genomics — Posted on 2022-03-27
730 A spatial genome aligner for multiplexed DNA-FISH
Jia, B. B.; Jussila, A. P.; Kern, J. C.; Zhu, Q.; Ren, B.
10.1101/2022.03.25.485845 — genomics — Posted on 2022-03-27
731 Ecological and evolutionary consequences of selective interspecific information use
Hamalainen, R.; Kajanus, M. H.; Forsman, J. T.; Kivela, S. M.; Seppanen, J.-T.; Loukola, O. J.
10.1101/2022.03.25.485764 — evolutionary biology — Posted on 2022-03-27
735 Habitat resource overlap in two broad-ranged sympatric Neotropical forest eagles
Sutton, L. J.; Anderson, D. L.; Franco, M.; Gomes, F. B.; McClure, C. J.; Miranda, E. B.; Vargas, F. H.; Vargas Gonzalez, J. d. J.; Puschendorf, R.
10.1101/2022.03.24.485595 — ecology — Posted on 2022-03-27
737 Long-term temperature trend in Kamchatka supports expansion of harmful algae
Samarkhanov, K.; Mirasbekov, Y.; Meirkhanova, A.; Zhumakhanova, A.; Malashenkov, D.; Kovalji, A.; Barteneva, N. S.
10.1101/2022.03.24.485652 — ecology — Posted on 2022-03-27
741 Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells
Deng, T.; Tristan, C. A.; Weber, C.; Chu, P.-H.; Ryu, S.; Jovanovic, V. M.; Ormanoglu, P.; Twumasi, P.; Shim, J.; Jayakar, S.; Zhang, H.-X. B.; Jo, S.; Voss, T. C.; Simeonov, A.; Bean, B. P.; Woolf, C. J.; Singec, I.
10.1101/2022.03.24.485622 — developmental biology — Posted on 2022-03-27
745 PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.
Poli, A.; Pennacchio, F. A.; Nastaly, P.; Ghisleni, A.; Crestani, M.; Pramotton, F. M.; Iannelli, F.; Beznusenko, G.; Mironov, A. A.; Panzetta, V.; Fusco, S.; Sheth, B.; Paolo, N.; Poulikakos, D.; Ferrari, A.; Gauthier, N.; Divecha, N.; Maiuri, P.
10.1101/2022.03.25.485814 — cell biology — Posted on 2022-03-27
748 Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
Giles, J. R.; Ngiow, S. F.; Manne, S.; Baxter, A. E.; Khan, O.; Wang, P.; Staupe, R.; Abdel-Hakeem, M. S.; Huang, H.; Mathew, D.; Painter, M. M.; Wu, J. E.; Huang, Y. J.; Goel, R.; Wherry, E. J.
10.1101/2022.03.27.485974 — immunology — Posted on 2022-03-27
749 Peripheral blood T-cell deficiency and hyperinflammatory monocyte responses associate with MAC lung disease
Lindestam Arlehamn, C. S.; Benson, B.; Kuan, R.; Dill-McFarland, K. A.; Peterson, G. J.; Paul, S.; Nguyen, F. K.; Gilman, R. H.; Saito, M.; Taplitz, R.; Arentz, M.; Goss, C. H.; Aitken, M. L.; Horne, D. J.; Shah, J. A.; Sette, A.; Hawn, T. R.
10.1101/2022.03.25.485768 — immunology — Posted on 2022-03-27
750 A novel maxillofacial technique to deliver drugs to the visual pathway, the optic nerve and the retina using the glymphatic system.
Arunachalam, J. P.; Rajendran, R.; Chidambaram, S.; Krishnagopal, S.; Bhavani, S.; Subha, V.; Veeravarmal, V.; Prasad, H.; Anoop, U. R.; Verma, K.
10.1101/2022.03.23.485523 — neuroscience — Posted on 2022-03-27
751 Suboptimal foraging decisions and involvement of the ventral tegmental area in human opioid addiction
Raio, C. M.; Biernacki, K.; Kapoor, A.; Wengler, K.; Bonagura, D.; Xue, J.; Constantino, S. M.; Horga, G.; Konova, A. B.
10.1101/2022.03.24.485654 — neuroscience — Posted on 2022-03-27
752 Structural and functional MRI data differentially predict chronological age and behavioral memory performance
Soch, J.; Richter, A.; Kizilirmak, J. M.; Schütze, H.; Feldhoff, H.; Fischer, L.; Knopf, L.; Raschick, M.; Schult, A.; Düzel, E.; Schott, B. H.
10.1101/2022.03.24.485603 — neuroscience — Posted on 2022-03-27
754 HALO: A software tool for real-time head alignment in the MR scanner
Zhao, Z.; Galiana, G.; Zillo, C.; Camarro, T.; Qiu, M.; Papademetris, X.; Hampson, M.
10.1101/2022.03.23.485491 — neuroscience — Posted on 2022-03-27
755 Local 5-HT signal bi-directionally regulates the coincidence time window of associative learning
Zeng, J.; Li, X.; Zhangren, Z.; Lv, M.; Wang, Y.; Tan, K.; Xia, X.; Wan, J.; Jing, M.; Yang, Y.; Li, Y.; Li, Y.
10.1101/2022.03.27.485970 — neuroscience — Posted on 2022-03-27
758 Spatiotemporal patterns of sleep spindle activity in human anterior thalamus and cortex
Bernhard, H.; Schaper, F. L. W. V. J.; Janssen, M. L. F.; Gommer, E. D.; Jansma, B. M.; Van Kranen-Mastenbroek, V.; Rouhl, R. P. W.; Weerd, P. d.; Reithler, J.; Roberts, M. J.; DBS studygroup,
10.1101/2022.03.25.485812 — neuroscience — Posted on 2022-03-27
759 Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Dona, M. S. I.; Hsu, I.; Meuth, A. I.; Brown, S. M.; Bailey, C. A.; Aragonez, C. G.; Chandrasekar, B.; Martinez-Lemus, L. A.; DeMarco, V. G.; Grisanti, L. A.; Jaffe, I. Z.; Pinto, A. R.; Bender, S. B.
10.1101/2022.03.24.485542 — physiology — Posted on 2022-03-27
760 TCGADEPMAP -- Mapping Translational Dependencies and Synthetic Lethalities within The Cancer Genome Atlas
Shi, X.; Verduzco, D.; Petiwala, S.; Jeffries, C.; Lu, C.; Anton, T.; Gekas, C.; Barnes, M.; Roy, S.; Ramathal, C.; Flister, M. J.; Dezso, Z.
10.1101/2022.03.24.485544 — cancer biology — Posted on 2022-03-27
761 Proton-transporting heliorhodopsins from marine giant viruses
Kandori, H.; Hososhima, S.; Beja, O.; Mizutori, R.; Shigemura, S.; Pushkarev, A.; Konno, M.; Katayama, K.; Inoue, K.; Tsunoda, S. P.; Abe-Yoshizumi, R.; Rozenberg, A.
10.1101/2022.03.24.485645 — biophysics — Posted on 2022-03-27
762 L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Liu, Z.; Quinones-Valdez, G.; Fu, T.; Choudhury, M.; Reese, F.; Mortazavi, A.; Xiao, X.
10.1101/2022.03.23.485515 — bioinformatics — Posted on 2022-03-27
764 diemr: Genome polarisation for detecting barriers to geneflow in R
Baird, S. J. E.; Petruzela, J.; Jaron, I.; Skrabanek, P.; Martinkova, N.
10.1101/2022.03.24.485605 — bioinformatics — Posted on 2022-03-27
765 CellSium - Versatile Cell Simulator for Microcolony Ground Truth Generation
Sachs, C. C.; Ruzaeva, K.; Seiffarth, J.; Wiechert, W.; Berkels, B.; Noeh, K.
10.1101/2022.03.24.485611 — bioinformatics — Posted on 2022-03-27
767 Gfastats: conversion, evaluation and manipulation of genome sequences using assembly graphs
Formenti, G.; Abueg, L.; Brajuka, A.; Brajuka, N.; Gallardo, C.; Giani, A.; Fedrigo, O.; Jarvis, E. D.
10.1101/2022.03.24.485682 — bioinformatics — Posted on 2022-03-27
774 Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition
Koyunlar, C.; Gioacchino, E.; Vadgama, D.; de Looper, H.; Zink, J.; Hoogenboezem, R.; Havermans, M.; Bindels, E.; Dzierzak, E.; Touw, I. P.; de Pater, E.
10.1101/2022.03.24.485642 — developmental biology — Posted on 2022-03-27
775 From perception to action: Intracortical recordings reveal cortical gradients of human exogenous attention
Seidel Malkinson, T.; Bayle, D. J.; Kaufmann, B. C.; Liu, J.; Bourgeois, A.; Lehongre, K.; Fernandez-Vidal, S.; Navarro, V.; Adam, C.; Margulies, D. S.; Sitt, J. D.; Bartolomeo, P.
10.1101/2021.01.02.425103 — neuroscience — Posted on 2022-03-27
778 A Conformation-specific Nanobody Targeting the NMN-activated State of SARM1
Hou, Y. N.; Cai, Y.; Li, W. H.; He, W. M.; Zhao, Z. Y.; Zhu, W. J.; Wang, Q.; Liu, J.; Lee, H. C.; Goran, S.; Zhang, H.; Zhao, Y. J.
10.1101/2022.03.25.485784 — molecular biology — Posted on 2022-03-27
780 Drug design and repurposing with a sequence-to-drug paradigm
Chen, L.; Fan, Z.; Chang, J.; Yang, R.; Guo, H.; Zhang, Y.; Yang, T.; Zhou, C.; Chen, Z.; Zheng, C.; Hao, X.; Zhang, K.; Cui, R.; Ding, Y.; Zhang, N.; Luo, X.; Jiang, H.; Zhang, S.; Zheng, M.
10.1101/2022.03.26.485909 — molecular biology — Posted on 2022-03-27
781 Degeneracy in the neurological model of auditory speech repetition
Sajid, N.; Gajardo Vidal, A.; Ekert, J. O.; Lorca, D.; Ploras Team, ; Hope, T. M.; Green, D. W.; Friston, K. J.; Price, C. J.
10.1101/2022.03.25.485823 — neuroscience — Posted on 2022-03-27
784 Nr2f1-dependent shaping of mitochondrial architecture in newborn mouse hippocampal neurons unravels novel insights into the neurodevelopmental disorder BBSOAS
Bonzano, S.; Michelon, F.; Crisci, I.; Molineris, I.; Neri, F.; Oliviero, S.; Beckervordersandforth, R.; Lie, D. C.; Peretto, P.; Bovetti, S.; Studer, M.; De Marchis, S.
10.1101/2022.03.25.485113 — neuroscience — Posted on 2022-03-27
785 Fast-synaptic axo-axonal transmission from striatal cholinergic interneurons onto dopamine fibers.
Kramer, P. F.; Brill-Weil, S.; Cummins, A.; Zhang, R.; Camacho-Hernandez, G. A.; Newman, A. H.; Eldridge, M. A.; Averbeck, B. B.; Khaliq, Z. M.
10.1101/2022.03.25.485828 — neuroscience — Posted on 2022-03-27
787 Kiawah and Seabrook islands are a critical site for the rufa red knot (Calidris canutus rufa)
Pelton, M. M.; Padula, S. R.; Garcia-Walther, J.; Andrews, M.; Mercer, R.; Porter, R.; Sanders, F.; Thibault, J.; Senner, N. R.; Linscott, J. A.
10.1101/2022.03.21.485188 — ecology — Posted on 2022-03-26
789 Dynamics of Gut Microbiome, IgA Response and Plasma Metabolome in Development of Pediatric Celiac Disease
Girdhar, K.; Huang, Q.; Dogru, Y. D.; Yang, Y.; Tolstikov, V.; Chrudinova, M.; Raisingani, A.; Ludvigsson, J. F.; Kiebish, M. A.; Palm, N. W.; Ludvigsson, J.; ALTINDIS, E.
10.1101/2020.02.29.971242 — immunology — Posted on 2022-03-26
790 Improved correspondence of fMRI visual field localizer data after cortex-based macroanatomical alignment
Qubad, M.; Barnes-Scheufler, C. V.; Schaum, M.; Raspor, E.; Roesler, L.; Peters, B.; Schiweck, C.; Goebel, R.; Reif, A.; Bittner, R. A.
10.1101/2021.02.26.433066 — neuroscience — Posted on 2022-03-26
791 Disentangling five dimensions of animacy in human brain and behaviour
Jozwik, K. M.; Najarro, E.; van den Bosch, J. J.; Charest, I.; Cichy, R. M.; Kriegeskorte, N.
10.1101/2021.09.12.459854 — neuroscience — Posted on 2022-03-26
793 A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins
Lazar, N.; Mesarich, C. H.; Petit-Houdenot, Y.; Talbi, N.; Li de la Sierra-Gallay, I.; Zelie, E.; Blondeau, K.; Gracy, J.; Ollivier, B.; Blaise, F.; Rouxel, T.; Balesdent, M.-H.; Idnurm, A.; van Tilbeurgh, H.; Fudal, I.
10.1101/2020.12.17.423041 — plant biology — Posted on 2022-03-26
794 WDR82 mediated H3K4me3 is associated with tumor proliferation and therapeutic efficacy in pediatric high-grade gliomas
Wadhwani, N.; Nayak, S.; Wang, Y.; Hashizume, R.; Jie, C.; Mania-Farnell, B.; James, C. D.; Xi, G.; Tomita, T.
10.1101/2022.03.09.483606 — cancer biology — Posted on 2022-03-26
795 Comparative assessment of quantification methods for tumor tissue phosphoproteomics
Zhang, Y.; Dreyer, B.; Govorukhina, N.; Heberle, A. M.; Koncarevic, S.; Krisp, C.; Opitz, C. A.; Pfander, P.; Bischoff, R.; Schluter, H.; Kwiatkowski, M.; Thedieck, K.; Horvatovich, P.
10.1101/2022.02.07.479414 — biochemistry — Posted on 2022-03-26
797 In silico Investigation of Molecular Networks Linking Gastrointestinal Diseases, Malnutrition, and Sarcopenia
Hoch, M.; Ehlers, L.; Bannert, K.; Stanke, C.; Brauer, D.; Caton, V.; Lamprecht, G.; Wolkenhauer, O.; Jaster, R.; Wolfien, M.
10.1101/2022.03.23.485443 — systems biology — Posted on 2022-03-26
800 Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea
Watanabe, H.; Du, W.; Son, J.; Sui, L.; Asahara, S.-i.; Kurland, I. J.; Kuo, T.; Kitamoto, T.; Miyachi, Y.; de Cabo, R.; Accili, D.
10.1101/2022.03.23.485508 — physiology — Posted on 2022-03-26
802 Spatiotemporal variations in retrovirus-host interactions among Darwin's finches
Hill, J.; Lillie, M.; Pettersson, M. E.; Rubin, C.-J.; Grant, R.; Grant, P.; Andersson, L.; Jern, P.
10.1101/2022.03.25.485756 — evolutionary biology — Posted on 2022-03-26
805 Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
Elbeck, Z.; Hossain, M. B.; Siga, H.; Oskolkov, N.; Karlsson, F.; Lindgren, J.; Walentinsson, A.; Remedios, C. D.; Koppenhöfer, D.; Jarvis, R.; Bürli, R.; Jamier, T.; Franssen, E.; Firth, M.; Degasperi, A.; Bendtsen, C.; Dudek, J.; Kohlhaas, M.; Nickel, A. G.; Lund, L. H.; Maack, C.; Vegvari, A.; Betsholtz, C.
10.1101/2022.03.26.485908 — molecular biology — Posted on 2022-03-26
810 Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs
Chiaranunt, P.; Burrows, K.; Ngai, L.; Cao, E. Y.; Tai, S. L.; Hamidzada, H.; Wong, A.; Kuypers, M.; Despot, T.; Momen, A.; Lim, S. M.; Mallevaey, T.; Conway, T.; Imamura, H.; Epelman, S.; Mortha, A.
10.1101/2022.03.23.485563 — immunology — Posted on 2022-03-26
814 Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies
Goldsteen, P.; Sabogal Guaqueta, A.; Bos, S.; Kistemaker, L.; Van der Koog, L.; Eggens, M.; Halayko, A. J.; Dolga, A.; Gosens, R.
10.1101/2022.03.23.485449 — neuroscience — Posted on 2022-03-26
816 Glioblastoma states are defined by cohabitating cellular populations with progression-, imaging- and sex-distinct patterns
Bond, K. M.; Curtin, L.; Hawkins-Daarud, A.; Urcuyo, J. C.; De Leon, G.; Sereduk, C.; Singleton, K. W.; Langworthy, J. M.; Jackson, P. R.; Krishna, C.; Zimmerman, R. S.; Patra, D. P.; Bendok, B. R.; Smith, K.; Nakaji, P.; Donev, K.; Baxter, L. C.; Mrugala, M. M.; Al-Dalahmah, O.; Hu, L. S.; Tran, N. L.; Rubin, J. B.; Canoll, P.; Swanson, K. R.
10.1101/2022.03.23.485500 — cancer biology — Posted on 2022-03-26
818 Structural visualization of the tubulin folding pathway directed by eukaryotic chaperonin TRiC
Gestaut, D. R.; Zhao, Y.; Park, J.; Ma, B.; Leitner, A.; Collier, M.; Pintilie, G.; Roh, S. H.; Chiu, W.; Frydman, J.
10.1101/2022.03.25.483853 — biochemistry — Posted on 2022-03-26
819 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design
Dam, K.-M. A.; Barnes, C. O.; Gristick, H. B.; Schoofs, T.; Nussenzweig, M. C.; Bjorkman, P. J.
10.1101/2022.03.25.485873 — biochemistry — Posted on 2022-03-26
821 Unearthing the global impact of mining construction minerals on biodiversity
Torres, A.; zu Ermgassen, S. O. S. E.; Ferri-Yanez, F.; Navarro, L. M.; Rosa, I. M. D.; Teixeira, F. Z.; Wittkopp, C.; Liu, J.
10.1101/2022.03.23.485272 — ecology — Posted on 2022-03-26
825 Telomerase-independent maintenance of telomere length in a vertebrate
Yu, Q.; Gates, P.; Rogers, S.; Mikicic, I.; Elewa, A.; Salomon, F.; Lachnit, M.; Caldarelli, A.; Flores-Rodriguez, N.; Cesare, A. J.; Simon, A.; Yun, M.
10.1101/2022.03.25.485759 — molecular biology — Posted on 2022-03-26
826 A Conformation-specific Nanobody Targeting the NMN-activated State of SARM1
Hou, Y. N.; Cai, Y.; Li, W. H.; He, W. M.; Zhao, Z. Y.; Zhu, W. J.; Wang, Q.; Liu, J.; Lee, H. C.; Goran, S.; Zhang, H.; Zhao, Y. J.
10.1101/2022.03.25.485784 — molecular biology — Posted on 2022-03-26
827 Drug design and repurposing with a sequence-to-drug paradigm
Chen, L. C.; Fan, Z.; Chang, J.; Yang, R.; Guo, H.; Zhang, Y.; Yang, T.; Zhou, C.; Chen, Z.; Zheng, C.; Hao, X.; Zhang, K.; Cui, R.; Ding, Y.; Zhang, N.; Luo, X.; Jiang, H.; Zhang, S.; Zheng, M.
10.1101/2022.03.26.485909 — molecular biology — Posted on 2022-03-26
828 Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against C. neoformans
Hoy, M. J.; Park, E.; Lee, H.; Lim, W. Y.; Cole, D. C.; DeBouver, N. D.; Bobay, B. G.; Pierce, P. G.; Fox, D.; Ciofani, M.; Juvvadi, P. R.; Steinbach, W.; Hong, J.; Heitman, J.
10.1101/2022.03.25.485831 — microbiology — Posted on 2022-03-26
830 Transcriptome of epibiont Saccharibacteria Nanosynbacter lyticus strain TM7x during establishment of symbiosis
Hendrickson, E. L.; Batbileg, B.; Kristopher, K. A.; Lamont, E. I.; Cen, L.; Chang, Y.; Liu, J.; Shi, W.; He, X.; McLean, J. S.
10.1101/2022.03.25.485537 — microbiology — Posted on 2022-03-26
833 RNA-targeting CRISPR-Cas13 Provides Broad-spectrum Phage Immunity
Adler, B. A.; Hessler, T.; Cress, B. F.; Mutalik, V. K.; Barrangou, R. K.; Banfield, J.; Doudna, J. A.
10.1101/2022.03.25.485874 — microbiology — Posted on 2022-03-26
834 A new monoclonal antibody enables BAR analysis of subcellular importin β1 interactomes
Song, D.-A.; Alber, S.; Doron-Mandel, E.; Schmid, V.; Albus, C. A.; Leitner, O.; Hamawi, H.; Oses-Prieto, J. A.; Burlingame, A.; Fainzilber, M.; Rishal, I.
10.1101/2022.03.23.485495 — neuroscience — Posted on 2022-03-26
835 Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice
Saito, K.; Dickey, J. E.; Rodeghiero, S. R.; Toth, B. A.; Kelly, M. J.; Deng, Y.; Singh, U.; Deng, G.; Jiang, J.; Cui, H.
10.1101/2022.03.22.485385 — physiology — Posted on 2022-03-26
836 Keratose sponges in ancient carbonates - a problem of interpretation
Neuweiler, F.; Kershaw, S.; Boulvain, F.; Matysik, M.; Sendino, C.; McMenamin, M.; Wood, R.
10.1101/2022.03.23.485445 — paleontology — Posted on 2022-03-26
837 Multifactorial remodeling of the cancer immunopeptidome by interferon gamma
Newey, A.; Yu, L.; Barber, L.; Choudhary, J.; Bassani-Sternberg, M.; Gerlinger, M.
10.1101/2022.03.23.485466 — cancer biology — Posted on 2022-03-26
838 At-home blood collection and stabilization in high temperature climates using homeRNA
Brown, L. G.; Haack, A. J.; Kennedy, D. S.; Adams, K. N.; Stolarczuk, J. E.; Takezawa, M. G.; Berthier, E.; Thongpang, S.; Lim, F. Y.; Chaussabel, D.; Garand, M.; Theberge, A. B.
10.1101/2022.03.23.485526 — bioengineering — Posted on 2022-03-26
841 CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation
Carrasco, K.; Montersino, C.; Derviaux, C.; Saez-Ayala, M.; Hoffer, L.; Restouin, A.; Castellano, R.; Casassa, J.; Roche, P.; Pasquier, E.; Combes, S.; Morelli, X.; Collette, Y.; Betzi, S.
10.1101/2021.12.13.472388 — cancer biology — Posted on 2022-03-26
843 Constitutively active STAT5b feminizes mouse liver gene expression
Lau-Corona, D.; Ma, H.; Vergato, C.; Sarmento-Cabral, A.; del Rio-Moreno, M.; Kineman, R. D.; Waxman, D. J.
10.1101/2022.02.14.480424 — genomics — Posted on 2022-03-26
845 Individual behavioral trajectories shape whole-brain connectivity in mice
Bogado Lopes, J.; Senko, A. N.; Bahnsen, K.; Geisler, D.; Kim, E.; Bernanos, M.; Cash, D.; Ehrlich, S.; Vernon, A. C.; Kempermann, G.
10.1101/2022.03.25.485806 — neuroscience — Posted on 2022-03-26
846 Neural responses to biological motion distinguish autistic and schizotypal traits in the general population
Hudson, M.; Santavirta, S.; Putkinen, V. J.; Seppala, K.; Sun, L.; Karjalainen, T.; Karlsson, H.; Hirvonen, J.; Nummenmaa, L.
10.1101/2022.03.24.485704 — neuroscience — Posted on 2022-03-26
847 Complement facilitates developmental microglial pruning of astrocyte and vascular networks
Gnanaguru, G.; Tabor, S. J.; Bonilla, G. M.; Sadreyev, R.; Yuda, K.; Köhl, J.; Connor, K. M.
10.1101/2022.01.12.476001 — developmental biology — Posted on 2022-03-26
849 DLK-dependent biphasic reactivation of herpes simplex virus latency established in the absence of antivirals
Dochnal, S. A.; Merchant, H.; Schinlever, A.; Babnis, A.; Depledge, D. P.; Wilson, A.; Cliffe, A. R.
10.1101/2022.02.25.482019 — microbiology — Posted on 2022-03-26
850 Flexible neural control of motor units
Marshall, N. J.; Glaser, J. I.; Trautmann, E. M.; Amematsro, E. A.; Perkins, S. M.; Shadlen, M. N.; Abbott, L. F.; Cunningham, J. P.; Churchland, M. M.
10.1101/2021.05.05.442653 — neuroscience — Posted on 2022-03-26
855 Examination of genome-wide ortholog variation in clinical and environmental isolates of the fungal pathogen Aspergillus fumigatus
Horta, M. A. C.; Steenwyk, J. L.; Mead, M. E.; dos Santos, L. H. B.; Zhao, S.; Gibbons, J. G.; Marcet-Houben, M.; Gabaldon, T.; Rokas, A.; Goldman, G.
10.1101/2022.03.23.485522 — bioinformatics — Posted on 2022-03-26
858 Expression and subcellular localization of USH1C/harmonin in the human retina provides insights into pathophysiology and therapy of Usher syndrome
Nagel-Wolfrum, K.; Fadl, B. R.; Becker, M. M.; Wunderlich, K. A.; Schaefer, J.; Sturm, D.; Guer, B.; Kaplan, L.; Andreani, T.; Goldmann, T.; Brooks, M.; Starostik, M. R.; Apel, M.; Fath, K. R.; Stingl, K.; Kohl, S.; DeAngelis, M. M.; Schloetzer-Schrehardt, U.; Kim, I. K.; Owen, L. A.; Vetter, J. M.; Pfeiffer, N.; Andrade-Navarro, M. A.; Grosche, A. A.; Swaroop, A.; Wolfrum, U.
10.1101/2021.08.27.457962 — molecular biology — Posted on 2022-03-25
863 Spinal cord associative plasticity improves forelimb sensorimotor function after cervical injury
Pal, A.; Park, H.; Ramamurthy, A.; Asan, A. S.; Bethea, T.; Johnkutty, M.; Carmel, J. B.
10.1101/2020.12.07.398289 — neuroscience — Posted on 2022-03-25
864 Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability
Schlesinger, L. S.; Sadee, W.; Cheeseman, I. H.; Papp, A.; Pietrzak, M.; Seweryn, M.; Zhou, X.; Lin, S.; Williams, A. M.; Arnett, E.; Azad, A. K.
10.1101/2022.03.14.484235 — systems biology — Posted on 2022-03-25
866 RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine
Wood, E. C.; Glen, A. K.; Kvarfordt, L. G.; Womack, F.; Acevedo, L.; Yoon, T. S.; Ma, C.; Flores, V.; Sinha, M.; Chodpathumwan, Y.; Termehchy, A.; Roach, J. C.; Mendoza, L.; Hoffman, A. S.; Deutsch, E. W.; Koslicki, D.; Ramsey, S. A.
10.1101/2021.10.17.464747 — bioinformatics — Posted on 2022-03-25
868 Metrics of High Cofluctuation and Entropy to Describe Control of Cardiac Function in the Stellate Ganglion
Gurel, N. Z.; Sudarshan, K. B.; Hadaya, J.; Karavos, A.; Temma, T.; Hori, Y.; Armour, A. J.; Kember, G.; Ajijola, O. A.
10.1101/2021.09.28.462183 — bioengineering — Posted on 2022-03-25
869 Mechanism of glycogen synthase inactivation and interaction with glycogenin
Marr, L.; Biswas, D.; Daly, L. A.; Browning, C.; Vial, S.; Maskell, D. P.; Hudson, C.; Pollard, J.; Bertrand, J.; Ranson, N. A.; Khatter, H.; Eyers, C. E.; Sakamoto, K.; Zeqiraj, E.
10.1101/2021.11.14.468517 — biochemistry — Posted on 2022-03-25
872 Tunable Cellular Localization and Extensive Cytoskeleton-Interplay of Reflectins
Song, J.; Chuanyang, L.; Li, B.; Liu, L.; Zeng, L.; Ye, Z.; Wu, W.; Hu, B.
10.1101/2021.08.23.457345 — cell biology — Posted on 2022-03-25
873 Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis
Dunham, C. S.; Mackenzie, M. E.; Nakano, H.; Kim, A. R.; Nakano, A.; Stieg, A. Z.; Gimzewski, J. K.
10.1101/2022.03.25.485780 — cell biology — Posted on 2022-03-25
874 NeoRdRp: A comprehensive dataset for identifying RNA-dependent RNA polymerase of various RNA viruses from metatranscriptomic data
Sakaguchi, S.; Urayama, S.-i.; Takaki, Y.; Hirosuna, K.; Wu, H.; Suzuki, Y.; Nunoura, T.; Nakano, T.; Nakagawa, S.
10.1101/2021.12.31.474423 — microbiology — Posted on 2022-03-25
875 Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells
Mensink, M.; Schrama, E.; Cuadrado, E.; van den Biggelaar, M.; Amsen, D.; Borst, J.; de Kivit, S.
10.1101/2021.10.30.466569 — immunology — Posted on 2022-03-25
876 Differential Hebbian learning with time-continuous signals for active noise reduction
Möller, K.; Kappel, D.; Tamosiunaite, M.; Tetzlaff, C.; Porr, B.; Wörgötter, F.
10.1101/2022.03.25.485849 — neuroscience — Posted on 2022-03-25
877 Evidence for the role of music on the growth and signal response in duckweed
Ye, Z.; Yang, R.; Xue, Y.; Chen, X.; Xu, Z.; Ren, Q.; Sun, J.; Ma, X.; Yang, L.
10.1101/2022.03.25.485777 — plant biology — Posted on 2022-03-25
879 The DNA-based global positioning system--a theoretical framework for large-scale spatial genomics
Greenstreet, L.; Afanassiev, A.; Kijima, Y.; Heitz, M.; Ishiguro, S.; King, S.; Yachie, N.; Schiebinger, G.
10.1101/2022.03.22.485380 — bioinformatics — Posted on 2022-03-25
882 Prevalence Estimates of Putatively Pathogenic Leptin Variants in the gnomAD Database
Rajcsanyi, L. S.; Zheng, Y.; Fischer-Posovszky, P.; Wabitsch, M.; Hebebrand, J.; Hinney, A.
10.1101/2022.03.25.485774 — genetics — Posted on 2022-03-25
883 Population dynamics of free-roaming dogs in Europe and implications for population control
Smith, L. M.; Goold, C.; Quinnell, R.; Munteanu, A.; Hartmann, S.; Dalla Villa, P.; Collins, L.
10.1101/2022.03.25.485772 — ecology — Posted on 2022-03-25
884 Dynamics in vertical transmission of viruses in naturally selected and traditionally managed honey bee colonies across Europe
Claeys Bouuaert, D.; De Smet, L.; Brunain, M.; Dahle, B.; Blacquiere, T.; Dalmon, A.; Dezmirean, D.; Dylan, E.; Filipi, J.; Giurgiu, A.; Gregorc, A.; Kefuss, J.; Locke, B.; de Miranda, J. R.; Oddie, M.; Panziera, D.; Parejo, M.; Pinto, A. M.; de Graaf, D. C.
10.1101/2022.03.25.485775 — ecology — Posted on 2022-03-25
888 CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer
Schorcht, A.; van den Kerkhof, T. L. G. M.; Torres, J.; Schermer, E.; LaBranche, C.; Bontjer, I.; Brinkkemper, M.; Gulzar, N.; Han, A. X.; Burger, J.; Ozorowski, G.; Scott, J.; Schuitemaker, H.; Montefiori, D.; van Gils, M.; Ward, A. B.; Sanders, R. W.
10.1101/2022.03.23.485469 — immunology — Posted on 2022-03-25
889 Marked regional glial heterogeneity in the human white matter of the central nervous system
Seeker, L. A.; Bestard-Cuche, N.; Jäkel, S.; Kazakou, N.-L.; Bøstrand, S. M. K.; Kilpatrick, A. M.; Van Bruggen, D.; Kabbe, M.; Pohl, F. B.; Moslehi, Z.; Henderson, N. C.; Vallejos, C. A.; La Manno, G.; Castelo-Branco, G.; Williams, A.
10.1101/2022.03.22.485367 — neuroscience — Posted on 2022-03-25
891 Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer's disease
Hu, J.; Zhu, H.; Yang, Q.; Shen, H.; Chai, G.; Zhang, B.; Chen, S.; Chen, Q.; Cai, Z.; Li, H.; Hou, L.; Mo, W.
10.1101/2022.03.23.485446 — neuroscience — Posted on 2022-03-25
896 Conserved patterns across ion channels correlate with variant pathogenicity and clinical phenotypes
Bruenger, T.; Perez-Palma, E.; Montanucci, L.; Nothnagel, M.; Moller, R. S.; Schorge, S.; Zuberi, S.; Symonds, J.; Lemke, J. R.; Brunklaus, A.; Traynelis, S. F.; May, P.; Lal, D.
10.1101/2022.03.23.485339 — genetics — Posted on 2022-03-25
897 The genomics and physiology of abiotic stressors associated with global elevation gradients in Arabidopsis thaliana
Gamba, D.; Lorts, C.; Haile, A.; Sahay, S.; Lopez, L.; Xia, T.; Kulesza, E.; Elango, D.; Kerby, J.; Yifru, M.; Bulafu, C. E.; Wondimu, T.; Glowacka, K.; Lasky, J.
10.1101/2022.03.22.485410 — evolutionary biology — Posted on 2022-03-25
905 Particle-Swarm Based Modelling Reveals Two Distinct Classes of CRHPVN Neurons
Lameu, E. L.; Rasiah, N. P.; Baimoukhametova, D. V.; Loewen, S. P.; Bains, J. S.; Nicola, W.
10.1101/2022.03.22.485381 — neuroscience — Posted on 2022-03-25
908 Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists
Wang, H.; Hetzer, F.; Huang, W.; Qu, Q.; Meyerowitz, J.; Kaindl, J.; Huebner, H.; Skiniotis, G.; Kobilka, B.; Gmeiner, P.
10.1101/2022.03.22.485330 — pharmacology and toxicology — Posted on 2022-03-25
909 A model for quorum-sensing mediated stochastic biofilm nucleation
Sinclair, P.; Brackley, C. A.; Carballo Pacheco, M.; Allen, R. J.
10.1101/2022.03.23.485488 — biophysics — Posted on 2022-03-25
912 Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats
Deal, A. W.; Thurman, A.; Seshie, O.; Szalanczy, A.; Beeson, A.; Cockerham, M.; Risemberg, E. L.; Lenzo, A.; Ozimek, N.; Langefeld, C.; Valdar, W.; Solberg Woods, L. C.
10.1101/2022.03.25.485743 — genetics — Posted on 2022-03-25
913 Towards a multi-stressor theory for coral reefs in a changing world
Bieg, C.; Valles, H.; Tewfik, A.; Lapointe, B. E.; McCann, K. S.
10.1101/2022.03.22.485402 — ecology — Posted on 2022-03-25
914 Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection
Lawrence, A.-L. E.; Berger, R. P.; Hill, D. R.; Huang, S.; Yadagiri, V. K.; Bons, B.; Fields, C.; Sule, G. J.; Knight, J. S.; Wobus, C. E.; Spence, J.; Young, V.; O'Riordan, M. X.; Abuaita, B.
10.1101/2022.03.25.485742 — microbiology — Posted on 2022-03-25
916 Neural activity in the anterior cingulate cortex is required for effort-based decision making
Kashay, A. Q.; Cheung, J. Y.; Vaknalli, R. N.; Delaney, M. J.; Navarro, M. B.; Neuwirth, M. E.; Wilke, S. A.
10.1101/2022.03.22.485350 — neuroscience — Posted on 2022-03-25
921 Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-Like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system
De Marco Verissimo, C.; Lopez-Corrales, J.; Dorey, A. L.; Cwiklinski, K.; Lalor, R.; Calvani, N. E. D.; Jewhurst, H. L.; Doyle, S.; Dalton, J. P.
10.1101/2022.03.25.485815 — biochemistry — Posted on 2022-03-25
922 Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain
Lin, Y.-L.; Yang, Z.-S.; Wong, W.-Y.; Lin, S.-C.; Wang, S.-J.; Chen, S.-P.; Cheng, J.-K.; Lu, H.; Lien, C.-C.
10.1101/2022.03.22.485320 — neuroscience — Posted on 2022-03-25
928 MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation
Hui, S. C. N.; Saleh, M.; Zoellner, H. J.; Oeltzschner, G.; Fan, H.; Li, Y.; Song, Y.; Jiang, H.; Near, J.; Lu, H.; Mori, S.; Edden, R.
10.1101/2022.03.22.485310 — bioengineering — Posted on 2022-03-25
929 Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies
Cherry, C.; Andorko, J. I.; Krishnan, K.; Mejias, J. C.; Nguyen, H. H.; Stivers, K. B.; Gray-Gaillard, E. F.; Ruta, A.; Hamada, N.; Hamada, M.; Sturmlechner, I.; Trewartha, S.; Michel, J. H.; Huyer, L. D.; Wolf, M. T.; Tam, A.; Pena, A. N.; Le Saux, C. J.; Fertig, E. J.; Baker, D. J.; Housseau, F.; van Deursen, J. M.; Pardoll, D. M.; Elisseeff, J. H.
10.1101/2022.03.22.485297 — bioengineering — Posted on 2022-03-25
930 High-throughput and high-sensitivity biomarker monitoring in body fluid by FAIMS-enhanced fast LC SureQuant™ IS targeted quantitation
Kalogeropoulos, K.; Savickas, S.; Haack, A. M.; Larsen, C. A.; Mikosinski, J.; Schoof, E. M.; Smola, H.; Bundgaard, L.; auf dem Keller, U.
10.1101/2022.03.22.485266 — biochemistry — Posted on 2022-03-25
932 Fewer non-native insects in freshwater than in terrestrial habitats across continents
Sendek, A.; Baity-Jesi, M.; Altermatt, F.; Bader, M. K. F.; Liebhold, A. M.; Turner, R.; Roques, A.; Seebens, H.; Spaak, P.; Vorburger, C.; Brockerhoff, E. G.
10.1101/2022.03.22.485042 — ecology — Posted on 2022-03-25
934 A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes
Ma, H.; de Zwaan, E.; Guo, Y. E.; Cejas, P.; Thiru, P.; van de Bunt, M.; Jeppesen, J.; Syamala, S.; Dall'Agnese, A.; Abraham, B.; Fu, D.; Garrett-Engele, C.; Lee, T.; Long, H.; Griffith, L.; Young, R.; Jaenisch, R.
10.1101/2022.03.24.485641 — developmental biology — Posted on 2022-03-25
935 Patient-derived parathyroid organoids as tracer and drug-screening application model
Noltes, M. E.; Sondorp, L. H. J.; Kracht, L.; Antunes, I. F.; Wardenaar, R.; Kelder, W.; Kemper, A.; Szymanski, W.; Zandee, W. T.; Jansen, L.; Brouwers, A. H.; Coppes, R. P.; Kruijff, S.
10.1101/2022.03.24.485627 — cell biology — Posted on 2022-03-25
936 Acute manipulation and real-time visualization of membrane trafficking and exocytosis in Drosophila
Glashauser, J.; Camelo, C.; Hollmann, M.; Isasti Sanchez, J.; Jacobs, T.; Backer, W.; Forster, D.; Luschnig, S.
10.1101/2022.03.25.483021 — cell biology — Posted on 2022-03-25
937 A Computational Pipeline to Identify Potential Drug Targets and Interacting Chemotypes in SARS-CoV-2
Sandholtz, S. H.; Drocco, J. A.; Zemla, A. T.; Torres, M. W.; Silva, M. S.; Allen, J. E.
10.1101/2022.03.24.485222 — bioinformatics — Posted on 2022-03-25
940 Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 variants of concern by HMOX-1 upregulation in human cells
Le-Trilling, V. T. K.; Mennerich, D.; Schuler, C.; Sakson, R.; Lill, J. K.; Kopczynski, D.; Loroch, S.; Flores-Martinez, Y.; Katschinski, B.; Wohlgemuth, K.; Gunzer, M.; Meyer, F.; Dittmer, U.; Sickmann, A.; Trilling, M.
10.1101/2020.11.18.388710 — microbiology — Posted on 2022-03-25
942 Gene-rich X chromosomes implicate intragenomic conflict in the evolution of bizarre genetic systems
Anderson, N.; Jaron, K. S.; Hodson, C. N.; Couger, M. B.; Sevcik, J.; Weinstein, B.; Pirro, S.; Ross, L.; Roy, S. W.
10.1101/2020.10.04.325340 — evolutionary biology — Posted on 2022-03-25
944 Pupillometry and electroencephalography in the digit span task
Pavlov, Y. G.; Kasanov, D.; Kosachenko, A. I.; Kotyusov, A.; Busch, N. A.
10.1101/2021.10.21.465288 — neuroscience — Posted on 2022-03-25
945 Algal photosystem I dimer and high resolution model of PSI:plastocyanin complex
Naschberger, A.; Mosebach, L.; Tobiasson, V.; Kuhlgert, S.; Scholz, M.; Perez-Boerema, A.; Takahashi, Y.; Hippler, M.; Amunts, A.
10.1101/2021.08.30.458224 — plant biology — Posted on 2022-03-25
946 High resolution analysis of proteolytic substrate processing
Schillinger, J.; Koci, M.; Bravo Rodriguez, K.; Heilmann, G.; Kaschani, F.; Kaiser, M.; Beuck, C.; Luecke, H.; Huber, R.; Hellerschmied, D.; Burston, S. G.; Ehrmann, M.
10.1101/2022.03.24.485615 — biochemistry — Posted on 2022-03-25
948 Gamete interaction protein evolution evinces Pantherines hybridizing history
Pisciottano, F.; Campos, M. C.; Penna, C.; Bruque, C. D.; Gabaldon, T.; Saragueta, P.
10.1101/2022.03.22.485370 — evolutionary biology — Posted on 2022-03-25
949 Global, regional, and cryptic population structure in a high gene-flow transatlantic fish
Jansson, E.; Faust, E.; Bekkevold, D.; Quintela, M.; Durif, C.; Halvorsen, K. T.; Dahle, G.; Pampoulie, C. S.; Kennedy, J.; Whittaker, B.; Unneland, L.; Andre, C.; Glover, K. A.
10.1101/2022.03.22.485384 — evolutionary biology — Posted on 2022-03-25
952 Lytic phages displayed protective effects against soft rot-causing Pectobacterium sp.
Parena, A. J. S.; Silva, B. B. I.; Mercado, R. M. L.; Sendon, A. A. A.; Signabon, F. B.; Balidion, J. F.; Encabo, J. R.
10.1101/2021.11.15.468558 — microbiology — Posted on 2022-03-25
954 Discovery of a Novel Inhibitor for Chikungunya Virus
Puhl, A. C.; Fernandes, R. S.; Godoy, A. S.; Gil, L. H. V. G.; Oliva, G.; Ekins, S.
10.1101/2022.03.23.485574 — microbiology — Posted on 2022-03-25
955 The lectin LecB induces patches with basolateral characteristics at the apical membrane to promote Pseudomonas aeruginosa host cell invasion
Thuenauer, R.; Kühn, K.; Guo, Y.; Kotsis, F.; Xu, M.; Trefzer, A.; Altmann, S.; Wehrum, S.; Heshmatpour, N.; Faust, B.; Landi, A.; Diedrich, B.; Dengjel, J.; Kuehn, W.; Imberty, A.; Römer, W.
10.1101/2022.03.23.485577 — microbiology — Posted on 2022-03-25
956 Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains
AOUADI, w.; Najburg, V.; Legendre, R.; Varet, H.; Kergoat, L.; Tangy, F.; Larrous, F.; Komarova, A.; Bourhy, H.
10.1101/2022.03.24.485606 — microbiology — Posted on 2022-03-25
957 Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq
Vazquez, S. E.; Mann, S. A.; Bodansky, A.; Kung, A. F.; Quandt, Z.; Ferre, E. M. N.; Landegren, N.; Eriksson, D.; Bastard, P.; Zhang, S.-Y.; Liu, J.; Mitchell, A.; Mandel-Brehm, C.; Miao, B.; Sowa, G.; Zorn, K.; Chan, A. Y.; Shimizu, C.; Tremoulet, A.; Lynch, K.; Wilson, M. R.; Kämpe, O.; Dobbs, K.; Delmonte, O. M.; Notarangelo, L. D.; Burns, J. C.; Casanova, J.-L.; Lionakis, M. S.; Torgerson, T. R.; Anderson, M. S.; DeRisi, J. L.
10.1101/2022.03.23.485509 — immunology — Posted on 2022-03-25
958 Stochastic fluctuations drive non-genetic evolution of proliferation in clonal cancer cell populations
Ortega-Sabater, C.; Fernandez-Calvo, G.; Dinic, J.; Podolski-Renic, A.; Pesic, M.; Perez-Garcia, V. M.
10.1101/2021.06.08.447479 — cancer biology — Posted on 2022-03-25
961 A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection
Bahnan, W.; Happonen, L.; Khakzad, H.; Kumra Ahnlide, V.; de Neergaard, T.; Wrighton, S.; Andre, O.; Bratanis, E.; Tang, D.; Hellmark, T.; Bjorck, L.; Shannon, O.; Malmstrom, L.; Malmstrom, J.; Nordenfelt, P.
10.1101/2021.03.01.433494 — immunology — Posted on 2022-03-25
962 Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model
Voss, L. F.; Howarth, A. J.; Wittenborn, T. R.; Hummelgaard, S.; Juul-Madsen, K.; Kastberg, K. S.; Pedersen, M. K.; Jensen, L.; Papanastasiou, A. D.; Vorup-Jensen, T.; Weyer, K.; Degn, S. E.
10.1101/2022.03.04.482991 — immunology — Posted on 2022-03-25
963 Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
Simola, J.; Siebenhühner, F.; Myrov, V.; Kantojärvi, K.; Paunio, T.; Palva, J. M.; Brattico, E.; Palva, S.
10.1101/2021.11.16.468778 — neuroscience — Posted on 2022-03-25
965 Can single-component protein condensates form multiphase architectures?
Garaizar Suarez, A.; R Espinosa, J.; Joseph, J. A.; Krainer, G.; Shen, Y.; Knowles, T. P. J.; Collepardo-Guevara, R.
10.1101/2021.10.09.463670 — biophysics — Posted on 2022-03-25
967 Genome assembly, structural variants, and genetic differentiation between Lake Whitefish young species pairs (Coregonus sp.) with long and short reads
Mérot, C.; Stenløkk, K. S. R.; Venney, C.; Laporte, M.; Moser, M.; Normandeau, E.; Àrnyasi, M.; Kent, M.; Rougeux, C.; Flynn, J. M.; Lien, S.; Bernatchez, L.
10.1101/2022.01.15.476463 — evolutionary biology — Posted on 2022-03-25
968 Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate
Duan, X.; Norris, D. M.; Humphrey, S. J.; Yang, P.; Cooke, K. C.; Bultitude, W. P.; Parker, B. L.; Conway, O. J.; Burchfield, J. G.; Krycer, J. R.; Brodsky, F. M.; James, D. E.; Fazakerley, D. J.
10.1101/2020.12.07.415257 — cell biology — Posted on 2022-03-25
971 A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate
Xiao, M. J.; Wu, C.-H.; Meek, G.; Kelly, B.; Young, L. E. A.; Martire, S.; Castillo, D. B.; Saha, P.; Dube, A. L.; Gentry, M.; Banaszynski, L. A.; Sun, R. C.; KIKANI, C.
10.1101/2022.03.24.485713 — cell biology — Posted on 2022-03-25
972 LSMMD-MA: Scaling multimodal data integration for single-cell genomics data analysis
Meng-Papaxanthos, L.; Zhang, R.; Li, G.; Cuturi, M.; Noble, W. S.; Vert, J.-P.
10.1101/2022.03.23.485536 — bioinformatics — Posted on 2022-03-25
976 Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic
Issac, D.; Cohen, S.; Hershcovitch, M.; Taraz, M.; Kissig, O.; Waddington, D.; Chin, P.; Friedrich, T.
10.1101/2022.03.24.485618 — bioinformatics — Posted on 2022-03-24
977 Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human Obesity
Crouse, W. L.; Das, S. K.; Le, T.; Keele, G. R.; Holl, K.; Seshi, O.; Craddock, A. L.; Sharma, N.; Comeau, M.; Langefeld, C.; Hawkins, G.; Mott, R.; Valdar, W.; Solberg Woods, L.
10.1101/2022.03.24.485632 — genomics — Posted on 2022-03-24
978 Accelerating Minimap2 for accurate long read alignment on GPUs
Sadasivan, H.; Maric, M.; Dawson, E.; Iyer, V.; Israeli, J.; Narayanasamy, S.
10.1101/2022.03.09.483575 — genomics — Posted on 2022-03-24
979 A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development
Solivan-Rivera, J.; Yang Loureiro, Z.; DeSouza, T.; Desai, A.; Yang, Q.; Rojas-Rodriguez, R.; Skritakis, P.; Joyce, S.; Zhong, D.; Nguyen, T.; Corvera, S.
10.1101/2021.12.29.474474 — developmental biology — Posted on 2022-03-24
980 TFAP2 paralogs facilitate chromatin access for MITF at pigmentation genes but inhibit expression of cell-cell adhesion genes independently of MITF
Kenny, C.; Dilshat, R.; Seberg, H.; Van Otterloo, E.; Bonde, G.; Helverson, A.; Franke, C. M.; Steingrimsson, E.; Cornell, R. A.
10.1101/2021.11.23.469757 — developmental biology — Posted on 2022-03-24
982 Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.
Arbon, D.; Zeniskova, K.; Subrtova, K.; Mach, J.; Stursa, J.; Machado, M.; Zahedifard, F.; Lestinova, T.; Hierro-Yap, C.; Neuzil, J.; Volf, P.; Ganter, M.; Zoltner, M.; Zikova, A.; Werner, L.; Sutak, R.
10.1101/2022.03.24.485593 — microbiology — Posted on 2022-03-24
983 A MademoiseLLE domain binding platform links the key RNA transporter to endosomes
Devan, S.-K.; Schott-Verdugo, S.; Muentjes, K.; Bismar, L.; Reiners, J.; Hachani, E.; Schmitt, L.; Hoeppner, A.; Smits, S. H.; Gohlke, H.; Feldbruegge, M.
10.1101/2021.10.25.465676 — microbiology — Posted on 2022-03-24
985 A somatosensory computation that unifies limbs and tools
Miller, L.; Fabio, C.; de Vignemont, F.; Roy, A.; Medendorp, W. P.; Farne, A.
10.1101/2021.12.09.472009 — neuroscience — Posted on 2022-03-24
987 Astroglial CD38 regulates social memory and synapse formation through SPARCL1 in the medial prefrontal cortex
HATTORI, T.; Cherepanov, S. M.; Sakaga, R.; Roboon, J.; Nguyen, D. T.; Ishii, H.; Takarada-Iemata, M.; Nishiuchi, T.; Kannon, T.; Hosomichi, K.; Tajima, A.; Yamamoto, Y.; Okamoto, H.; Sugawara, A.; Higashida, H.; Hori, O.
10.1101/2021.12.23.474051 — neuroscience — Posted on 2022-03-24
992 Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanism
Liang, X.; Xiao, J.; Li, X.; Wen, Y.; Che, X.; Ma, Y.; Zhang, X.; Zhang, Y.; Jian, D.; Wang, P.; Xuan, C.; Yu, G.; Li, L.; Zhang, H.
10.1101/2022.03.24.485560 — biochemistry — Posted on 2022-03-24
994 N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase
Rosenau, J.; Grothaus, I. L.; Yang, Y.; Dinesh Kumar, N.; Ciacchi, L. C.; Kelm, S.; Waespy, M.
10.1101/2021.12.13.472379 — biochemistry — Posted on 2022-03-24
997 A CpG island-encoded mechanism protects genes from premature transcription termination
Hughes, A. L.; Szczurek, A. T.; Kelley, J. R.; Lastuvkova, A.; Turberfield, A. H.; Dimitrova, E.; Blackledge, N. P.; Klose, R. J.
10.1101/2022.03.24.485638 — molecular biology — Posted on 2022-03-24
998 Loss of transgene expression limits liver gene therapy in primates
Greig, J. A.; Breton, C.; Martins, K. M.; Zhu, Y.; He, Z.; White, J.; Bell, P.; Wang, L.; Wilson, J. M.
10.1101/2022.03.24.485675 — molecular biology — Posted on 2022-03-24
999 Distinct bile salt hydrolase substrate preferences dictate C. difficile pathogenesis
Foley, M. H.; Walker, M. E.; Stewart, A. K.; O'Flaherty, S.; Gentry, E. C.; Allen, G.; Patel, S.; Pan, M.; Beaty, V. V.; Vanhoy, M. E.; Dougherty, M. K.; McGill, S. K.; Gulati, A.; Dorrestein, P.; Baker, E. S.; Redinbo, M. R.; Barrangou, R.; Theriot, C. M.
10.1101/2022.03.24.485529 — microbiology — Posted on 2022-03-24
1000 Changes in m6A RNA methylation of goat lung following PPRV infection
Khan, R. I. N.; Praharaj, M. R.; Malla, W. A.; Hosamani, N.; Saxena, S.; Mishra, B.; Rajak, K. K.; Dhanavelu, M.; Mishra, B. P.; Sajjanar, B.; Gandham, R. K.
10.1101/2022.03.24.485342 — microbiology — Posted on 2022-03-24
1005 Reaction-diffusion patterning of DNA-based artificial cells
Leathers, A.; Walczak, M.; Brady, R. A.; Al Samad, A.; Kotar, J.; Booth, M. J.; Cicuta, P.; Di Michele, L.
10.1101/2022.03.24.485404 — synthetic biology — Posted on 2022-03-24
1008 Genome-wide analysis of the non-coding RNA synthetic genetic network reveals extensive plasticity and unique phenotypes in yeast
Fraczek, M.; Timouma, S.; Balarezo-Cisneros, L. N.; Parker, S.; Duangrattanalert, K.; Feng, M. W.; Griffiths-Jones, S.; O'Keefe, R.; Delneri, D.
10.1101/2022.03.10.483001 — genetics — Posted on 2022-03-24
1009 The role of evolutionary modes for trait-based cascades in mutualistic networks
Bastazini, V. A. G.; Debastiani, V.; Cappelatti, L.; Guimaraes, P.; Pillar, V. D. P.
10.1101/2021.10.05.462726 — ecology — Posted on 2022-03-24
1010 Human Elp3/Kat9 is a mitochondrial tRNA modifying enzyme
Boutoual, R.; Hyunsun, J.; Heckenbach, I.; Tiwari, R.; Kasler, H.; Lerner, C. A.; Shah, S.; Schilling, B.; Calvanese, V.; Rardin, M. J.; Scheibye-Knudsen, M.; Verdin, E.
10.1101/2022.03.24.485634 — molecular biology — Posted on 2022-03-24
1012 A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass
Hill, J. H.; Massaquoi, M. S.; Sweeney, E. G.; Wall, E. S.; Bell, R.; Kallio, K.; Derrick, D.; Murtaugh, L. C.; Parthasarathy, R.; Remington, S. J.; Round, J. L.; Guillemin, K.
10.1101/2022.03.24.485696 — molecular biology — Posted on 2022-03-24
1015 Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA
Aziati, I. D.; McFarland, D.; Antia, A.; Joshi, A.; Aviles Gamboa, A.; Lee, P.; Harastani, H. H.; Wang, D.; Adalsteinsson, S. A.; Boon, A.
10.1101/2022.03.23.485543 — microbiology — Posted on 2022-03-24
1017 Spatial turnover of soil viral populations and genotypes overlain by cohesive responses to moisture in grasslands
Santos-Medellin, C.; Estera-Molina, K.; Yuan, M.; Pett-Ridge, J.; Firestone, M. K.; Emerson, J. B.
10.1101/2022.03.24.485562 — microbiology — Posted on 2022-03-24
1021 A novel oral GyrB/ParE dual binding inhibitor effective against multidrug resistant Neisseria gonorrhoeae and other high-threat pathogens
Park, S.; Russo, R.; Westfall, L.; Shrestha, R.; Zimmerman, M.; Dartois, V. A.; Kurepina, N.; Kreiswith, B.; Singleton, E.; LI, S.-G.; Mittal, N.; Ahn, Y.-M.; Bilotta, j.; Connolly, K. L.; Jerse, A. E.; Freundlich, J. S.; Perlin, D. S.
10.1101/2022.03.23.485573 — microbiology — Posted on 2022-03-24
1022 Antifungal activity of Cinnamomum cassia and Origanum compactum essential oils against Aspergillus oryzae
Leclercq, M.; Commenge, I.; Bouriot, M.; Crusset, F.; Gonzalez, P.; Grimaud, J.; Yates, F.; Sarfati-Bert, J.; Saint-Pol, A.
10.1101/2022.03.24.485625 — microbiology — Posted on 2022-03-24
1023 Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in Mice
Sharpe, M. C.; Pyles, K. D.; Hallcox, T.; Kamm, D. R.; Piechowski, M.; Fisk, B.; Albert, C. J.; Carpenter, D. H.; Ulmasov, B.; Ford, D. A.; Neuschwander-Tetri, B. A.; McCommis, K. S.
10.1101/2022.03.24.485677 — pathology — Posted on 2022-03-24
1024 Virtual screening for small molecule pathway regulators by image profile matching
Rohban, M. H.; Fuller, A. M.; Tan, C.; Goldstein, J. T.; Syangtan, D.; Gutnick, A.; Nijsure, M. P.; Rigby, M.; Sacher, J. R.; Corsello, S. M.; Peppler, G. B.; Bogaczynska, M.; Boghossian, A.; Ciotti, G. E.; DeVine, A.; Doan, M.; Gale, J. P.; Derynck, R.; Turbyville, T.; Boerckel, J. D.; Singh, S.; Kiessling, L. L.; Schwarz, T. L.; Varelas, X.; Wagner, F. F.; Kafri, R.; Eisinger-Mathason, T. S. K.; Carpenter, A. E.
10.1101/2021.07.29.454377 — bioinformatics — Posted on 2022-03-24
1025 Occurrence and quantities of DNA modifications across the tree of life
Varma, S. J.; Calvani, E.; Gruening, N.-M.; Messner, C. B.; Grayson, N.; Capuano, F.; Muelleder, M.; Ralser, M.
10.1101/2022.03.22.485282 — genomics — Posted on 2022-03-24
1028 SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications
Schloer, A.; Hirschberg, S.; Ben Amor, G.; Meister, T. L.; Arora, P.; Pöhlmann, S.; Hoffmann, M.; Pfaender, S.; Kamal Eddin, O.; Kamhieh-Milz, J.; Hanack, K.
10.1101/2022.03.24.485614 — immunology — Posted on 2022-03-24
1029 Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model
Bauer, L.; Rissmann, M.; Benavides, F.; Leijten, L.; Begeman, L.; Veldhuis Kroeze, E.; van Run, P.; Koopmans, M. P. G.; Rockx, B.; van Riel, D.
10.1101/2022.03.24.485596 — microbiology — Posted on 2022-03-24
1031 Temporal coordination between chromosome mobility and homologous recombination
Joseph, F.; Lee, S. J.; Bryant, E. E.; Reid, R. J. D.; Sunjevaric, I.; Rothstein, R.
10.1101/2022.03.24.485580 — cell biology — Posted on 2022-03-24
1032 Vimentin intermediate filaments organize organellar architecture in response to ER stress
Cremer, T.; Voortman, L. M.; van Elsland, D.; Bos, E.; Ter Haar, L. R.; Koning, R. I.; Berlin, I.; Neefjes, J.
10.1101/2022.03.24.485587 — cell biology — Posted on 2022-03-24
1033 The actin assembly requirements of the formin Fus1 to build the fusion focus
Billault-Chaumartin, I.; Michon, L.; Anderson, C. A.; Yde, S. E.; Suarez, C.; Iwaszkiewicz, J.; Zoete, V.; Kovar, D. R.; Martin, S. G.
10.1101/2022.03.24.485616 — cell biology — Posted on 2022-03-24
1034 SPAG6 promotes cell migration and induces epithelial-to-mesenchymal transition in luminal breast cancer cells
Mijnes, J.; Bringezu, S.; Berger, J.; Schalla, C.; Rose, M.; von Serenyi, S.; Knuechel-Clarke, R.; Sechi, A.; Dahl, E.
10.1101/2022.03.24.485597 — cell biology — Posted on 2022-03-24
1035 A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced-neurons
Papadimitriou, E.; Koutsoudaki, P. N.; Thanou, I.; Karamitros, T.; Karagkouni, D.; Chroni-Tzartou, D.; Gaitanou, M.; Gkemisis, C.; Margariti, M.; Xingi, E.; Tzartos, S. J.; Hatzigeorgiou, A. G.; Thomaidou, D.
10.1101/2020.06.01.127126 — neuroscience — Posted on 2022-03-24
1037 Influenza infection in ferrets with SARS-CoV-2 infection history
de Melo, C. V. B.; Peters, F.; van Dijken, H.; Lenz, S.; van de Ven, K.; Wijsman, L.; Gommersbach, A.; Schouten, T.; van Kasteren, P. B.; van den Brand, J. M. A.; de Jonge, J.
10.1101/2022.03.22.485425 — pathology — Posted on 2022-03-24
1039 A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian
Frank, U.; Chrysostomou, E.; Gornik, S.; Salinas-Saavedra, M.; Gahan, J.; Flici, H.; McMahon, E.; Thompson, K.; Hanley, S.; Kincoyne, M.; Schnitzler, C.; Gonzalez, P.; Baxevanis, A.
10.1101/2022.03.22.485278 — developmental biology — Posted on 2022-03-24
1041 Sensory neuron-associated macrophages proliferate in the sensory ganglia after peripheral nerve injury in a CX3CR1 signaling dependent manner
Guimaraes, R. M.; Silva, E. A.; Davoli-Ferreira, M.; Gomes, F. I. F.; Mendes, A.; Fonseca, M.; Damasceno, S.; Andrade, L. P.; Cunha, F. Q.; Alves-Filho, J. C.; Cunha, T. M.
10.1101/2022.03.22.485276 — immunology — Posted on 2022-03-24
1042 LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
Westendorf, K.; Zentelis, S.; Wang, L.; Foster, D.; Vaillancourt, P.; Wiggin, M.; Lovett, E.; van der Lee, R.; Hendle, J.; Pustilnik, A.; Sauder, J. M.; Kraft, L.; Hwang, Y.; Siegel, R. W.; Chen, J.; Heinz, B. A.; Higgs, R. E.; Kallewaard, N.; Jepson, K.; Goya, R.; Smith, M. A.; Collins, D. W.; Pellacani, D.; Xiang, P.; de Puyraimond, V.; Ricicova, M.; Devorkin, L.; Pritchard, C.; O'Neill, A.; Dalal, K.; Panwar, P.; Dhupar, H.; Garces, F. A.; Cohen, C. A.; Dye, J. M.; Huie, K. E.; Badger, C. V.; Kobasa, D.; Audet, J.; Freitas, J. J.; Hassanali, S.; Hughes, I.; Munoz, L.; Palma, H. C.; Ramamurt
10.1101/2021.04.30.442182 — immunology — Posted on 2022-03-24
1045 Global membrane tension is independent of polyacrylamide substrate stiffness
Kreysing, E.; Mc Hugh, J.; Foster, S. K.; Andresen, K.; Greenhalgh, R. D.; Pillai, E. K.; Dimitracopoulos, A.; Keyser, U. F.; Franze, K.
10.1101/2021.11.09.467973 — biophysics — Posted on 2022-03-24
1046 Mitochondrial phosphoproteomes are functionally specialized across tissues
Mann, M.; Hansen, F. M.; Kremer, L. S.; Karayel, O.; Kühl, I.; Bludau, I.; Larsson, N.-G.
10.1101/2022.03.23.485457 — biochemistry — Posted on 2022-03-24
1047 AGES: An auxin-inducible, GAL4-compatible, gene expression system for Drosophila
McClure, C. D.; Hassan, A.; Aughey, G. N.; Butt, K.; Estacio Gomez, A.; Duggal, A.; Ying Sia, C.; Barber, A. F.; Southall, T. D.
10.1101/2021.01.26.428209 — genetics — Posted on 2022-03-24
1048 The push-pull intercrop Desmodium does not repel, but intercepts and kills pests
Erdei, A. L.; David, A. B.; Savvidou, E. C.; Dzemedzionaite, V.; Chakravarthy, A.; Molnar, B. P.; Dekker, T.
10.1101/2022.03.08.482778 — ecology — Posted on 2022-03-24
1049 Reduction of nucleolar NOC1 accumulates pre-rRNAs and induces Xrp1 affecting growth and resulting in cell competition in Drosophila
Destefanis, F.; Manara, V.; Santarelli, S.; Zola, S.; Brambilla, M.; Viola, G.; Maragno, P.; Signoria, I.; Viero, G.; Pasini, M. E.; Penzo, M.; Bellosta, P.
10.1101/2021.07.06.451100 — cell biology — Posted on 2022-03-24
1050 Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG
Berg, M. D.; Zhu, Y.; Loll-Krippleber, R.; San Luis, B.-J.; Genereaux, J.; Boone, C.; Villen, J.; Brown, G. W.; Brandl, C. J.
10.1101/2022.03.22.485345 — molecular biology — Posted on 2022-03-24
1051 Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice
Gonzalez-Dominguez, I.; Martinez, J. L.; Slamanig, S.; Lemus, N.; Liu, Y.; Lai, T. Y.; Carreno, J. M.; Singh, G.; Singh, G.; Schotsaert, M.; Mena, I.; McCroskery, S.; Coughlan, L.; Krammer, F.; Garcia-Sastre, A.; Palese, P.; Sun, W.
10.1101/2022.03.21.485247 — immunology — Posted on 2022-03-24
1055 Semaphorin3F reduces vascular endothelial and smooth muscle cell PI3K activation and decreases neointimal plaque formation
Rattanasopa, C.; Castano Mayan, D.; Su, C.; Farrugia, A. J.; Corliano, M.; Nilcham, P.; Pang, C.; Hota, M.; Koh, S. M.; Lee, W. W.; Cibi, D. M.; Aiba, A.; Singh, M. K.; Wong, S. C.; Rotzschke, O.; Bershadsky, A.; Wei Hou, H.; Liehn, E. A.; Ghosh, S.; Singaraja, R. R.
10.1101/2022.03.22.485288 — physiology — Posted on 2022-03-24
1056 A weakly structured stem for human origins in Africa
Ragsdale, A. P.; Weaver, T. D.; Atkinson, E. G.; Hoal, E.; Moller, M.; Henn, B. M.; Gravel, S.
10.1101/2022.03.23.485528 — genomics — Posted on 2022-03-24
1059 Neural and cognitive correlates of performance in dynamic multi-modal settings
Dziego, C.; Bornkessel-Schlesewsky, I.; Jano, S.; Chatburn, A.; Schlesewsky, M.; Immink, M. A.; Sinha, R.; Irons, J.; Schmitt, M.; Chen, S.; Cross, Z. R.
10.1101/2022.03.23.485424 — neuroscience — Posted on 2022-03-24
1060 Probabilistic modeling of ambient noise in single-cell omics data
Sheng, C.; Lopes, R.; Li, G.; Schuierer, S.; Waldt, A.; Cuttat, R.; Dimitrieva, S.; Kauffmann, A.; Durand, E.; Galli, G. G.; Roma, G.; de Weck, A.
10.1101/2022.01.14.476312 — bioinformatics — Posted on 2022-03-24
1061 In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Imanishi, S.; Huang, L.; Itakura, S.; Ishizaka, M.; Iwasaki, Y.; Yamaguchi, T.; Miyamoto-Sato, E.
10.1101/2021.04.23.441075 — molecular biology — Posted on 2022-03-24
1062 Stem cells partner with matrix remodeling cells during regeneration
Benham-Pyle, B. W.; Mann, F. G.; Brewster, C. E.; Dewars, E. R.; Nowotarski, S. H.; Guerrero-Hernandez, C.; Malloy, S.; Hall, K. E.; Maddera, L. E.; Chen, S.; Morrison, J. A.; Slaughter, B. D.; Perera, A.; Alvarado, A. S.
10.1101/2022.03.20.485025 — developmental biology — Posted on 2022-03-24
1063 Self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induces protective immunity in mice
Liu, X.; Song, H.; Jiang, J.; Gao, X.; Yi, Y.; Shang, Y.; Li, J.; Li, D.; Zeng, Z.; Li, Y.; Zhang, Z.
10.1101/2021.02.05.428685 — microbiology — Posted on 2022-03-24
1064 Electroencephalographic dynamics of rhythmicbreath-based meditation
Tripathi, V.; Bhasker, L.; Kharya, C.; Bhatia, M.; Kochupillai, V.
10.1101/2022.03.09.483685 — neuroscience — Posted on 2022-03-24
1065 Hybrid conferences: opportunities, challenges and ways forward
Puccinelli, E.; Zeppilli, D.; Stefanoudis, P.; Wittische-Helou, A.; Kermorgant, M.; Fuchs, S.; Sarrazin, J.; Easton, E. E.; Weber, A. A.-T.
10.1101/2022.03.18.484941 — scientific communication and education — Posted on 2022-03-24
1069 A quartz crystal microbalance method to quantify the size of hyaluronan and other glycosaminoglycans on surfaces
Srimasorn, S.; Souter, L.; Green, D. E.; Djerbal, L.; Goodenough, A.; Duncan, J. A.; Roberts, A. R.; Zhang, X.; Debarre, D.; DeAngelis, P. L.; Kwok, J. C.; Richter, R. P.
10.1101/2022.02.28.482386 — biophysics — Posted on 2022-03-24
1071 Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Barnada, S. M.; Isopi, A.; Tejada-Martinez, D.; Goubert, C.; Patoori, S.; Pagliaroli, L.; Tracewell, M.; Trizzino, M.
10.1101/2022.01.10.475682 — genomics — Posted on 2022-03-23
1072 Systematic analysis of YFP gene traps reveals common discordance between mRNA and protein across the nervous system
Titlow, J. S.; Kiourlappou, M.; Palanca, A.; Lee, J. Y.; Gala, D. S.; Ennis, D.; Yu, J. J. S.; Young, F. L.; Pinto, D. M. S.; Garforth, S.; Francis, H. S.; Strivens, F.; Mulvey, H.; Dallman-Porter, A.; Thornton, S.; Arman, D.; Järvelin, A. I.; Thompson, M. K.; Kounatidis, I.; Parton, R. M.; Taylor, S.; Davis, I.
10.1101/2022.03.21.485142 — cell biology — Posted on 2022-03-24
1073 Dual Specificity Phosphatase 7 Drives the Formation of Cardiac Mesoderm in Mouse Embryonic Stem Cells
Sladecek, S.; Radaszkiewicz, K. A.; Bohmova, M.; Gybel, T.; Radaszkiewicz, T. W.; Pachernik, J.
10.1101/2022.01.18.476715 — cell biology — Posted on 2022-03-24
1074 The isoforms of pyruvate kinase act as nutrient sensors for the β-cell KATP channel
Foster, H. R.; Ho, T.; Potapenko, E.; Sdao, S. M.; Lewandowski, S. L.; VanDeusen, H. R.; Davidson, S. M.; Cardone, R. L.; Kibbey, R. G.; Merrins, M. J.
10.1101/2022.02.09.478817 — cell biology — Posted on 2022-03-24
1076 Transmit Field Bias Correction of T1w/T2w Myelin Maps
Glasser, M. F.; Coalson, T. S.; Harms, M. P.; Xu, J.; Baum, G. L.; Autio, J. A.; Auerbach, E. A.; Greve, D. N.; Yacoub, E.; Van Essen, D. C.; Bock, N. A.; Hayashi, T.
10.1101/2021.08.08.455570 — neuroscience — Posted on 2022-03-23
1078 Acoustic camera system for measuring ultrasound communication in mice
Matsumoto, J.; Kanno, K.; Kato, M.; Nishimaru, H.; Setogawa, T.; Chinzorig, C.; Shibata, T.; Nishijo, H.
10.1101/2021.12.12.468927 — neuroscience — Posted on 2022-03-23
1080 The Arabidopsis transcription factor NLP2 regulates early nitrate responses and integrates nitrate assimilation with energy and carbon skeleton supply
Durand, M.; Brehaut, V.; Clement, G.; Kelemen, Z.; Mace, J.; Feil, R.; Duville, G.; Launay-Avon, A.; Paysant-Le Roux, C.; Lunn, J. E.; Roudier, F.; Krapp, A.
10.1101/2022.03.21.485211 — plant biology — Posted on 2022-03-23
1082 Inferring a spatial code of cell-cell interactions across a whole animal body
Armingol, E.; Ghaddar, A.; Joshi, C. J.; Baghdassarian, H.; Shamie, I.; Chan, J.; Her, H.-L.; O'Rourke, E. J.; Lewis, N. E.
10.1101/2020.11.22.392217 — bioinformatics — Posted on 2022-03-23
1084 Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus
Harris, R. A.; Raveendran, M.; Lyfoung, D. T.; Sedlazeck, F. J.; Mahmoud, M.; Prall, T.; Karl, J.; Doddapaneni, H.; Meng, Q.; Han, Y.; Muzny, D.; Wiseman, R. W.; O'Connor, D. H.; Rogers, J.
10.1101/2021.07.05.451071 — genomics — Posted on 2022-03-23
1085 A global meta-analysis reveals higher life-history phenotypic variation in urban birds than in their non-urban neighbours
Capilla-Lasheras, P.; Thompson, M. J.; Sanchez-Tojar, A.; Haddou, Y.; Branston, C. J.; Reale, D.; Charmantier, A.; Dominoni, D. M.
10.1101/2021.09.24.461498 — evolutionary biology — Posted on 2022-03-23
1086 The conserved transcriptional program of metazoan male germ cells uncovers ancient origins of human infertility
Brattig Correia, R.; Almeida, J. M.; Wyrwoll, M. J.; Julca, I.; Sobral, D.; Misra, C. S.; Guilgur, L. G.; Schuppe, H.-C.; Silva, N.; Prudêncio, P.; Nóvoa, A.; Leocádio, A. S.; Bom, J.; Mallo, M.; Kliesch, S.; Mutwil, M.; Rocha, L. M.; Tüttelmann, F.; Becker, J. D.; Navarro-Costa, P.
10.1101/2022.03.02.482557 — evolutionary biology — Posted on 2022-03-23
1087 Endometriotic Organoids: A Novel In Vitro Model of Endometriotic Lesion Development.
Song, Y.; Burns, G. W.; Joshi, N. R.; Arora, R.; Kim, J. J.; Fazleabas, A. T.
10.1101/2022.02.15.480583 — cell biology — Posted on 2022-03-23
1092 Increased gene dosage and mRNA expression from chromosomal duplications in C. elegans
Ragipani, B.; Albritton, S. E.; Morao, A. K.; Mesquita, D.; Kramer, M.; Ercan, S.
10.1101/2022.03.22.485368 — genomics — Posted on 2022-03-23
1093 Fusarium solani species complex genomes reveal bases of compartmentalisation and animal pathogenesis
Hoh, D. Z.; Lee, H.-H.; Wada, N.; Liu, W.-A.; Lu, M. R.; Lai, C.-K.; Ke, H.-M.; Sun, P. F.; Tang, S.-L.; Chung, W.-H.; Chen, Y.-L.; Chung, C.-L.; Tsai, I. J.
10.1101/2022.03.22.485422 — genomics — Posted on 2022-03-23
1095 SPACA6 structure reveals a conserved superfamily of gamete fusion-associated proteins
Vance, T. D. R.; Yip, P.; Jimenez, E.; Li, S.; Gawol, D.; Byrnes, J.; Uson, I.; Ziyyat, A.; Lee, J. E.
10.1101/2022.03.23.484325 — developmental biology — Posted on 2022-03-23
1096 True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin
Gelleri, M.; Chen, S.-Y.; Szczurek, A.; Hübner, B.; Sterr, M.; Neumann, J.; Kröger, O.; Sadlo, F.; Imhoff, J.; Markaki, Y.; Hendzel, M. J.; Cremer, M.; Cremer, T.; Strickfaden, H.; Cremer, C.
10.1101/2022.03.23.485308 — cell biology — Posted on 2022-03-23
1101 Proteomic analysis reveals microvesicles containing NAMPT as mediators of radiation resistance in glioma
Panizza, E.; Regalado, B. D.; Wang, F.; Nakano, I.; Vacanti, N. M.; Cerione, R. A.; Antonyak, M. A.
10.1101/2022.03.23.485479 — cancer biology — Posted on 2022-03-23
1102 Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients
Liu, X.; Hogg, G. D.; zuo, c.; Baer, J. M.; Lander, V. E.; Kang, L.; Borcherding, N. C.; Knolhoff, B. L.; Osterhout, R. E.; Galkin, A. V.; Bruey, J. M.; Carter, L. L.; Mpoy, C.; Schwarz, J. K.; Park, H.; Gupta, V.; DeNardo, D.
10.1101/2022.03.22.485233 — cancer biology — Posted on 2022-03-23
1107 XY sex determination in a cnidarian
Chen, R.; Sanders, S. M.; Ma, Z.; Paschall, J.; Chang, E. S.; Riscoe, B. M.; Schnitzler, C. E.; Baxevanis, A. D.; Nicotra, M. L.
10.1101/2022.03.22.485406 — genetics — Posted on 2022-03-23
1111 Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus
Bui, H. B.; Watanabe, S.; Nomura, N.; Liu, K.; Uemura, T.; Inoue, M.; Tsutsumi, A.; Fujita, H.; Kinoshita, K.; Iwata, S.; Kikkawa, M.; Inaba, K.
10.1101/2022.03.23.485435 — molecular biology — Posted on 2022-03-23
1112 Gene editing for accelerated breeding in wheat
Thiyagarajan, K.; Noguera, L. M.; Pacheco, M.; Govindan, V.; Vikram, P.
10.1101/2022.03.23.485492 — molecular biology — Posted on 2022-03-23
1113 Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions
Malki, I.; Liepina, I.; Kogelnik, N.; Lightfoot, A.; Gonchar, O.; Watmuff, H.; Bottrill, A.; Fry, A. M.; Dominguez, C.
10.1101/2022.03.23.485498 — molecular biology — Posted on 2022-03-23
1115 A multiple comorbidities mouse model to assess atherosclerosis progression following lung infection in ApoE deficient mice
Bartlett, B.; Lee, S.; Ludewick, H. P.; Siew, T.; Verma, S.; Waterer, G.; Corrales-Medina, V.; Dwivedi, G.
10.1101/2022.03.23.485412 — molecular biology — Posted on 2022-03-23
1116 Population genetic analysis of Ophidiomyces ophidiicola, the causative agent of snake fungal disease, indicates recent introductions to the USA
Ladner, J. T.; Palmer, J. M.; Ettinger, C. L.; Stajich, J. E.; Farrell, T. M.; Glorioso, B. M.; Lawson, B.; Price, S. J.; Stengle, A. G.; Grear, D. A.; Lorch, J.
10.1101/2022.03.23.485546 — microbiology — Posted on 2022-03-23
1117 Classifying the activity states of small vertebrates using automated VHF telemetry
Gottwald, J.; Royaute, R.; Becker, M.; Geitz, T.; Hoechst, J.; Lampe, P.; Leister, L.; Lindner, K.; Maier, J.; Roesner, S.; Schabo, D. G.; Freisleben, B.; Mueller, T.; Brandl, R.; Farwig, N.; Nauss, T.
10.1101/2022.03.22.485147 — animal behavior and cognition — Posted on 2022-03-23
1118 An uncommon garden experiment: microenvironment has stronger influence on phenotypic variation than epigenetic memory in the clonal Lombardy poplar
Diez Rodriguez, B.; Pena, C.; Perez-Bello, P.; Bette, J.; Lerbs, L.; Mackenbach, T.; Wulle, S.; De Paoli, E.; Verhoeven, K. J. F.; Heer, K.; Opgenoorth, L.
10.1101/2022.03.22.485169 — ecology — Posted on 2022-03-23
1119 Enhancing the Fitness of Embryoid Bodies and Organoids by Chemical Cytoprotection
Ryu, S.; Weber, C.; Chu, P.-H.; Tristan, C. A.; Ernest, B.; Jovanovic, V. M.; Deng, T.; Slamecka, J.; Hong, H.; Braisted, J.; Hirst, M.; Simeonov, A.; Voss, T. C.; Singec, I.
10.1101/2022.03.21.485225 — developmental biology — Posted on 2022-03-23
1122 Human CD4+/CD8α+ regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation
Touch, S.; Godefroy, E.; Rolhion, N.; Danne, C.; Oeuvray, C.; Straube, M.; Galbert, C.; Brot, L.; Alonso Salgueiro, I.; Chadi, S.; Ledent, T.; Chatel, J. M.; Langella, P.; Jotereau, F.; Altare, F.; Sokol, H.
10.1101/2022.03.22.485277 — immunology — Posted on 2022-03-23
1123 Single cell Transcriptome and T cell Repertoire Mapping of the Mechanistic Signatures and T cell Trajectories Contributing to Vascular and Dermal Manifestations of Behcet Disease
Chang, L.; Zheng, Z.; Qinghua, Z.; Zhong, B.; Chen, C.; Cheng, X.; Ni, Q.; Che, T.; Zhao, Z.; Cao, C.; Zhou, Y.; Tang, X.; Zhai, Z.; Zhao, J.; Zhang, J.; Wang, L.; Wan, Y.; Chen, G.; Li, J.; Zou, L.; Wu, Y.
10.1101/2022.03.22.485251 — immunology — Posted on 2022-03-23
1127 An Orobanche cernua x Orobanche cumana segregating population provides insight into the regulation of germination specificity in a parasitic plant
Larose, H.; Plakhine, D.; Wycoff, N.; Zhang, N.; Conn, C.; Nelson, D. C.; Eizenberg, H.; Joel, D. M.; Tadmor, Y.; Westwood, J.
10.1101/2022.03.22.485355 — plant biology — Posted on 2022-03-23
1129 Strain design optimization using reinforcement learning
Sabzevari, M.; Szedmak, S.; Penttila, M.; Jouhten, P.; Rousu, J.
10.1101/2022.03.22.485285 — bioinformatics — Posted on 2022-03-23
1131 Occurrence and quantities of DNA modifications across the tree of life
Varma, S. J.; Calvani, E.; Gruening, N.-M.; Messner, C. B.; Grayson, N.; Capuano, F.; Muelleder, M.; Ralser, M.
10.1101/2022.03.22.485282 — genomics — Posted on 2022-03-23
1132 Structural architecture and brain network efficiency links polygenic scores to intelligence
Genc, E.; Metzen, D.; Fraenz, C.; Schlüter, C.; Völkle, M. C.; Arning, L.; Streit, F.; Nguyen, H. P.; Güntürkün, O.; Ocklenburg, S.; Kumsta, R.
10.1101/2022.03.22.485284 — genetics — Posted on 2022-03-23
1135 Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background
Hugo, L. E.; Rasic, G.; Maynard, A. J.; Ambrose, L.; Liddington, C.; Nath, N. S.; Graham, M.; Winterford, C.; Wimalasiri-Yapa, B. M. C. R.; Xi, Z.; Beebe, N. W.; Devine, G. J. E.
10.1101/2022.03.22.485408 — microbiology — Posted on 2022-03-23
1136 A Single-Cell Molecular Atlas of White Adipose Tissue Shows Differences in Myeloid and Lymphoid Cell Polarization in Type 2 Diabetes and HIV Infection
Bailin, S. S.; Kropski, J. A.; Gangula, R. D.; Hannah, L.; Simmons, J. D.; Mashayekhi, M.; Ye, F.; Fan, R.; Chopra, A.; Ramesh, R.; Mallal, S.; Warren, C. M.; Kalams, S. A.; Gabriel, C. L.; Wanjalla, C. N.; Koethe, J. R.
10.1101/2022.03.21.484794 — immunology — Posted on 2022-03-23
1137 Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
Servello, F. A.; Fernandes, R.; Eder, M.; Harris, N.; Martin, O. M.; Oswal, N.; Lindberg, A.; Derosiers, N.; Sengupta, P.; Stroustrup, N.; Apfeld, J.
10.1101/2022.03.21.485202 — neuroscience — Posted on 2022-03-23
1139 Galanin Analogs Prevent Seizure-Induced Respiratory Arrest
Collard, R.; Aziz, M. C.; Rapp, K.; Cutshall, C.; Duyvesteyn, E.; Metcalf, C. S.
10.1101/2022.03.21.485198 — neuroscience — Posted on 2022-03-23
1144 A wheat resistosome defines common principles of immune receptor channels
Forderer, A.; Li, E.; Lawson, A.; Deng, Y.-n.; Sun, Y.; Logemann, E.; Zhang, X.; Wen, J.; Han, Z.; Chang, J.; Chen, Y.-h.; Schulze-Lefert, P.; Chai, J.
10.1101/2022.03.23.485489 — plant biology — Posted on 2022-03-23
1145 Modulation of the DA1 pathway in maize shows that translatability of information from Arabidopsis to crops is complex
gong, P.; Demuynck, K.; De Block, J.; Aesaert, S.; Coussens, G.; Pauwels, L.; Inze, D.; Nelissen, H.
10.1101/2022.03.22.485335 — plant biology — Posted on 2022-03-23
1149 Identifying targetable metabolic dependencies across colorectal cancer progression
Legge, D. N.; Holt, A. K.; Bull, C. J.; Collard, T. J.; Kollareddy, M.; Bellamy, J.; Groves, S.; Ma, E. H.; Hazelwood, E.; Qualtrough, D.; Amulic, B.; Malik, K. N.; Williams, A. C.; Jones, N.; Vincent, E. E.
10.1101/2022.03.23.485483 — cancer biology — Posted on 2022-03-23
1150 Targeting Reductive Metabolic Shifts by T315I Mutation in BCR-ABL Myeloid Leukemia for Therapy
Huang, C. Y.; Chung, Y.-H.; Wu, S.-Y.; Wang, H.-Y.; Lin, Z.-Y.; Yang, T.-J.; Feng, J.-M.; Hu, C.-M.; Chang, Z.-F.
10.1101/2022.03.22.485260 — cancer biology — Posted on 2022-03-23
1155 Integrative Analysis of Checkpoint Blockade Response in Advanced Non-Small Cell Lung Cancer
Ravi, A.; Gainor, J. F.; Arniella, M. B.; Holton, M.; Freeman, S. S.; Stewart, C.; Leshchiner, I.; Kim, J.; Akiyama, Y.; Griffin, A. T.; Vokes, N. I.; Sakhi, M.; Kamesan, V.; Rizvi, H.; Ricciuti, B.; Forde, P. M.; Anagnostou, V.; Reiss, J. W.; Gibbons, D. L.; Pennell, N. A.; Velcheti, V.; Digumarthy, S. R.; Mino-Kenudson, M.; Califano, A.; Heymach, J. V.; Herbst, R. S.; Brahmer, J. R.; Schalper, K. A.; Velculescu, V. E.; Henick, B. S.; Rizvi, N.; Janne, P. A.; Awad, M. M.; Chow, A.; Greenbaum, B. D.; Luksza, M.; Shaw, A. T.; Wolchok, J.; Hacohen, N.; Getz, G.; Hellmann, M. D.
10.1101/2022.03.21.485199 — genomics — Posted on 2022-03-23
1156 Cross-trait assortative mating is widespread and inflates genetic correlation estimates
Border, R.; Athanasiadis, G.; Buil, A.; Schork, A.; Cai, N.; Young, A.; Werge, T.; Flint, J.; Kendler, K.; Sankararaman, S.; Dahl, A.; Zaitlen, N.
10.1101/2022.03.21.485215 — genetics — Posted on 2022-03-23
1158 Measuring plant diversity in a two-stage sampling design by Bayesian updated relative abundances
Damgaard, C.; Pedersen, M. H.; Bendsen, N. B.; Mikkelsen, D. L.; Ehlers, B. K.; Bataillon, T.
10.1101/2022.03.23.485475 — ecology — Posted on 2022-03-23
1159 Urbanization alters phenology of plant reproduction, foliar infection, and herbivory
Fox, Q. N.; Bugay, M. J.; Grant, E.; Shaw, O. S.; Farah, K. N.; Penczykowski, R. M.
10.1101/2022.03.22.485313 — ecology — Posted on 2022-03-23
1160 Kiawah and Seabrook islands are a critical site for the rufa red knot (Calidris canutus rufa)
Pelton, M. M.; Padula, S. R.; Garcia-Walther, J.; Andrews, M.; Mercer, R.; Porter, R.; Sanders, F.; Thibault, J.; Senner, N. R.; Linscott, J. A.
10.1101/2022.03.21.485188 — ecology — Posted on 2022-03-23
1162 Chromatin-associated lncRNA Malat1 regulates Th17 effector program and promotes intestinal inflammation
Ma, S.; Zhou, B.; Chen, N.; Luo, C.; Li, Y.; Patel, P. R.; Zheng, A.; Patel, S. A.; Hao, Y.; Chang, J. T.; Fu, X.; Huang, W. J. M.
10.1101/2022.03.21.485192 — immunology — Posted on 2022-03-23
1164 A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues
Chen, C.; Boorla, V. S.; Chowdhury, R.; Nissly, R. H.; Gontu, A.; Chothe, S. K.; LaBella, L.; Jakka, P.; Ramasamy, S.; Vandegrift, K. J.; Surendran Nair, M.; Kuchipudi, S. V.; Maranas, C. D.
10.1101/2022.03.22.485413 — biophysics — Posted on 2022-03-23
1166 Topologically engineered antibodies and Fc-fusion proteins: a new class of multifunctional therapeutic candidates for SARS-CoV-2, cancer, and other disease
Capon, D. J.; Troitskaya, L.; Chan, N. L. S.; Fomin, M.; Edman, U.; Frank, B.; Jin, J.; Martinelli, R.; Capon, B. Z.; Ferguson, G. A.; Gefter, M. L.; Simmons, G.
10.1101/2022.03.23.485397 — molecular biology — Posted on 2022-03-23
1168 A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Voigt, E. A.; Gerhardt, A.; Hanson, D.; Battisti, P.; Reed, S.; Singh, J.; Mohamath, R.; Jennewein, M. F.; Bakken, J.; Beaver, S.; Press, C.; Soon-Shiong, P.; Paddon, C. J.; Fox, C. B.; Casper, C.
10.1101/2022.03.22.485230 — immunology — Posted on 2022-03-23
1169 Intranasal Nanoemulsion Adjuvanted S-2P Vaccine Demonstrates Protection in Hamsters and Induces Systemic, Cell-Mediated and Mucosal Immunity in Mice
Ganesan, S.; Acosta, H.; Brigolin, C.; Orange, K.; Trabbic, K.; Chen, C.; Lien, C.-E.; Lin, Y.-J.; Lin, M.-Y.; Chuang, Y.-S.; Fattom, A.; Bitko, V.
10.1101/2022.03.22.485323 — immunology — Posted on 2022-03-23
1171 Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2
Fang, Z.; Peng, L.; Lin, Q.; Zhou, L.; Yang, L.; Feng, Y.; Ren, P.; Renauer, P. A.; Park, J. J.; Zhou, X.; Wilen, C. B.; Chen, S.
10.1101/2022.03.22.485418 — immunology — Posted on 2022-03-23
1173 Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
O'Sullivan, E. D.; Mylonas, K. J.; Bell, R.; Carbalho, C.; Baird, D. P.; Cairns, C.; Gallagher, K. M.; Campbell, R.; Docherty, M.; Laird, A.; Henderson, N.; Chandra, T.; Kirschner, K.; Conway, B.; Dihazi, G.; Zeisberg, M.; Hughes, J.; Denby, L.; Dihazi, H.; Ferenbach, D.
10.1101/2022.03.21.485189 — cell biology — Posted on 2022-03-23
1175 Mechanism of Tethered Agonist-Mediated Signaling by Polycystin-1
Pawnikar, S.; Magenheimer, B. S.; Nevarez-Munoz, E.; Maser, R. L.; Miao, Y.
10.1101/2021.08.05.455255 — biochemistry — Posted on 2022-03-23
1176 Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis
Kuo, A.; Checa, A.; Niaudet, C.; Jung, B.; Fu, Z.; Wheelock, C. E.; Singh, S. A.; Aikawa, M.; Smith, L. E.; Proia, R. L.; Hla, T.
10.1101/2022.03.22.485296 — developmental biology — Posted on 2022-03-23
1179 Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons
Ambrozkiewicz, M. C.; Borisova, E.; Newman, A. G.; Kraushar, M. L.; Schaub, T.; Dannenberg, R.; Brockmann, M.; Rosario, M.; Turko, P.; Jahn, O.; Kaplan, D. R.; Iwawaki, T.; Spahn, C. M. T.; Rosenmund, C.; Tarabykin, V.
10.1101/2021.06.23.449563 — neuroscience — Posted on 2022-03-23
1180 The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity
Ho, P.; Melms, J. C.; Rogava, M.; Frangieh, C. J.; Shah, S. B.; Walsh, Z.; Kyrysyuk, O.; Amin, A. D.; Caprio, L.; Fullerton, B. T.; Soni, R.; Ager, C. R.; Biermann, J.; Wang, Y.; Mu, M.; Fatima, H.; Moore, E. K.; Vasan, N.; Bakhoum, S. F.; Reiner, S. L.; Bernatchez, C.; Mace, E. M.; Wucherpfennig, K. W.; Schadendorf, D.; Schwartz, G. K.; Izar, B.
10.1101/2022.03.21.485049 — cancer biology — Posted on 2022-03-23
1182 Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination
Suberi, A.; Grun, M. K.; Mao, T.; Goldman-Israelow, B.; Reschke, M.; Grundler, J.; Akhtar, L.; Lee, T.; Shin, K.; Piotrowski-Daspit, A. S.; Homer, R.; Iwasaki, A.; Suh, H. W.; Saltzman, W. M.
10.1101/2022.03.22.485401 — bioengineering — Posted on 2022-03-23
1184 Small Molecule Modulation of the Archetypal UbiB protein COQ8
Murray, N. H.; Lewis, A.; Asquith, C. R. M.; Pabon, J. P. R.; Fang, Z.; Ptak, N.; Smith, R. W.; Vasta, J. D.; Zimprich, C. A.; Corona, C. R.; Robers, M. B.; Bingman, C. A.; Gross, M. L.; Henzler-Wildman, K.; Pagliarini, D. J.
10.1101/2022.03.22.485346 — biochemistry — Posted on 2022-03-23
1185 A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification
Edginton-White, B.; Maytum, A.; Kellaway, S. G.; Goode, D. K.; Keane, P.; Pagnuco, I.; Assi, S. A.; Ames, L.; Clarke, M. L.; Cockerill, P. N.; Gottgens, B.; Cazier, J.-B.; Bonifer, C.
10.1101/2022.03.22.485307 — genomics — Posted on 2022-03-23
1187 EukProt: a database of genome-scale predicted proteins across the diversity of eukaryotes
Richter, D. J.; Berney, C.; Strassert, J. F. H.; Poh, Y.-P.; Herman, E. K.; Munoz-Gomez, S. A.; Wideman, J. A.; Burki, F.; de Vargas, C.
10.1101/2020.06.30.180687 — evolutionary biology — Posted on 2022-03-23
1188 Fate and state transitions during human blood vessel organoid development
Nikolova, M. T.; He, Z.; Wimmer, R. A.; Seimiya, M.; Nikoloff, J. M.; Penninger, J. M.; Camp, J. G.; Treutlein, B.
10.1101/2022.03.23.485329 — developmental biology — Posted on 2022-03-23
1189 Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication - transcription conflicts
Scaramuzza, S.; Muste Sadurni, M.; Poovathumkadavil, D.; Natsume, T.; Rojas, P.; Kanemaki, M. T.; Saponaro, M.; Gambus, A.
10.1101/2022.03.23.485338 — cell biology — Posted on 2022-03-23
1190 A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells
Becker, H. J.; Ishida, R.; Wilkinson, A. C.; Kimura, T.; Lee, M. S. J.; Coban, C.; Ota, Y.; Tojo, A.; Kent, D.; Yamazaki, S.
10.1101/2022.03.23.485423 — cell biology — Posted on 2022-03-23
1191 Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution
Chen, A.; Sun, Y.; Lei, Y.; Li, C.; Liao, S.; Liang, Z.; Lin, F.; Yuan, N.; Li, M.; Wang, K.; Yang, M.; Zhang, S.; Zhuang, Z.; Meng, J.; Song, Q.; Zhang, Y.; Xu, Y.; Cui, L.; Han, L.; Yang, H.; Sun, X.; Fei, T.; Chen, B.; Li, W.; Huangfu, B.; Ma, K.; Li, Z.; Lin, Y.; Liu, Z.; Wang, H.; Zhong, Y.; Zhang, H.; Yu, Q.; Wang, Y.; Zhu, Z.; Liu, X.; Peng, J.; Liu, C.; Chen, W.; An, Y.; Xia, S.; Lu, Y.; Wang, M.; Song, X.; Liu, S.; Wang, Z.; Gong, C.; Huang, X.; Yuan, Y.; Zhao, Y.; Luo, Z.; Tan, X.; Liu, J.; Zheng, M.; Li, S.; Huang, Y.; Hong, Y.; Huang, Z.; Li, M.; Zhang, R.; Jin, M.; Li, Y.; Zhang,
10.1101/2022.03.23.485448 — cell biology — Posted on 2022-03-23
1194 An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques
Madden, P. J.; Thomas, Y.; Blair, R. V.; Samer, S.; Doyle, M.; Midkiff, C. C.; Doyle-Meyers, L. A.; Becker, M. E.; Arif, M. S.; McRaven, M. D.; Simons, L. M.; Carias, A. M.; Martinelli, E.; Lorenzo-Redondo, R.; Hultquist, J. F.; Villinger, F. J.; Veazey, R. S.; Hope, T. J.
10.1101/2022.02.25.481974 — immunology — Posted on 2022-03-23
1204 Distribution and molecular evolution of the anti-CRISPR family AcrIF7
Figueroa, W.; Cazares, A.; Cazares, D.; Wu, Y.; De la Cruz, A.; Welch, M.; Kameyama, L.; Nobrega, F.; Guarneros, G.
10.1101/2021.06.27.450086 — microbiology — Posted on 2022-03-23
1205 Network architecture producing swing to stance transitions in an insect walking system
Strohmer, B.; Mantziaris, C.; Kynigopoulos, D.; Manoonpong, P.; Bonde Larsen, L.; Büschges, A.
10.1101/2022.01.20.477058 — neuroscience — Posted on 2022-03-23
1208 AGES: An auxin-inducible, GAL4-compatible, gene expression system for Drosophila
McClure, C. D.; Hassan, A.; Duggal, A.; Ying Sia, C.; Southall, T. D.; Aughey, G. N.; Estacio Gomez, A.; Barber, A. F.; Butt, K.
10.1101/2021.01.26.428209 — genetics — Posted on 2022-03-23
1218 Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Barnada, S. M.; Isopi, A.; Tejada-Martinez, D.; Goubert, C.; Patoori, S.; Pagliaroli, L.; Tracewell, M.; Trizzino, M.
10.1101/2022.01.10.475682 — genomics — Posted on 2022-03-23
1219 Earliest photic zone niches probed by ancestral microbial rhodopsins
Sephus, C.; Fer, E.; Garcia, A. K.; Adam, Z. R.; Schwieterman, E.; Kacar, B.
10.1101/2021.11.18.469010 — evolutionary biology — Posted on 2022-03-23
1220 Dynamic coastal pelagic habitat drives rapid changes in growth and condition of juvenile sockeye salmon (Oncorhynchus nerka) during early marine migration
Garzke, J.; Forster, I.; Godwin, S.; Johnson, B. T.; Krkosek, M.; Mahara, N.; Pakhomov, E. A.; Rogers, L. A.; Hunt, B. P.
10.1101/2022.03.21.484660 — ecology — Posted on 2022-03-23
1221 Nr6a1 controls axially-restricted body elongation, segmentation, patterning and lineage allocation
Chang, Y.-C.; Wong, S. F. L.; Schroeder, J.; Hauswirth, G. M.; Shylo, N. A.; Moore, E. L.; Achilleos, A.; Garside, V.; Polo, J. M.; Manent, J.; Trainor, P.; McGlinn, E.
10.1101/2022.03.21.485239 — developmental biology — Posted on 2022-03-23
1222 Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits
Li, Z.; Bowers, E.; Zhu, J.; Yu, H.; Hardij, J.; Bagchi, D. P.; Mori, H.; Lewis, K. T.; Granger, K.; Schill, R. L.; Romanelli, S. M.; Abrishami, S.; Hankenson, K. D.; Singer, K.; Rosen, C. J.; MacDougald, O.
10.1101/2022.03.21.485120 — cell biology — Posted on 2022-03-23
1225 White matter microstructure shows sex differences in late childhood: Evidence from 6,797 children
Lawrence, K. E.; Abaryan, Z.; Laltoo, E.; Hernandez, L. M.; Gandal, M.; McCracken, J. T.; Thompson, P. M.
10.1101/2021.08.19.456728 — neuroscience — Posted on 2022-03-23
1226 Determinants of multiheme cytochrome extracellular electron transfer uncovered by systematic peptide insertion
Campbell, I. J.; Atkinson, J. T.; Carpenter, M. D.; Myerscough, D.; Su, L.; Ajo-Franklin, C. M.; Silberg, J. J.
10.1101/2022.03.09.483668 — synthetic biology — Posted on 2022-03-23
1227 Impaired iron recycling from erythrocytes is an early iron-dependent hallmark of aging
Slusarczyk, P.; Mandal, P. K.; Zurawska, G.; Niklewicz, M.; Kumari Chouhan, K.; Macias, M.; Szybinska, A.; Cybulska, M.; Krawczyk, O.; Herman, S.; Mikula, M.; Serwa, R.; Lenartowicz, M.; Pokrzywa, W.; Mleczko-Sanecka, K.
10.1101/2022.01.16.476518 — physiology — Posted on 2022-03-23
1228 A Topological Data Analytic Approach for Discovering Biophysical Signatures in Protein Dynamics
Tang, W. S.; da Silva, G. M.; Kirveslahti, H.; Skeens, E.; Feng, B.; Sudijono, T.; Yang, K. K.; Mukherjee, S.; Rubenstein, B.; Crawford, L.
10.1101/2021.07.28.454240 — biophysics — Posted on 2022-03-23
1229 Increasing the throughput of sensitive proteomics by plexDIA
Derks, J.; Leduc, A.; Wallmann, G.; Huffman, R. G.; Willetts, M.; Khan, S.; Specht, H.; Ralser, M.; Demichev, V.; Slavov, N.
10.1101/2021.11.03.467007 — bioengineering — Posted on 2022-03-22
1230 Identification of sex chromosomes using genomic and cytogenetic methods in a range-expanding spider, Argiope bruennichi (Araneae: Araneidae)
Sheffer, M. M.; Cordellier, M. M.; Forman, M.; Grewoldt, M.; Hoffmann, K.; Jensen, C.; Kotz, M.; Kral, J.; Kuss, A. W.; Liznarova, E.; Uhl, G.
10.1101/2021.10.06.463373 — genetics — Posted on 2022-03-22
1231 Whole-genome sequencing analysis of wild-caught house mice Mus musculus from Madagascar
Fujiwara, K.; Ranorosoa, M. C.; Ohdachi, S. D.; Arai, S.; Sakuma, Y.; Suzuki, H.; Osada, N.
10.1101/2021.09.10.459745 — genetics — Posted on 2022-03-23
1233 Single-value scores of memory-related fMRI activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging
Richter, A.; Soch, J.; Kizilirmak, J. M.; Fischer, L.; Schütze, H.; Assmann, A.; Behnisch, G.; Feldhoff, H.; Knopf, L.; Raschick, M.; Schult, A.; Seidenbecher, C. I.; Yakupov, R.; Düzel, E.; Schott, B. H.
10.1101/2022.02.04.479169 — neuroscience — Posted on 2022-03-22
1234 Hand cold pressor test induces thermogenesis in upper thoracic regions as measured by skin surface infrared thermography
Levtova, N.; Benoit, E.-A.; Jhajj, A. K.; Narayana, T.; Purkayastha, D.; Salimi, A.; Kakon, G.; Maurice-Ventouris, M. E. I.; Kaffash Mohamadi, A. A.; Kizhner, T.; Khayargoli, P.; Darlington, P. J.
10.1101/2022.03.22.485388 — physiology — Posted on 2022-03-22
1235 Characterization of methylation profiles in spontaneous preterm birth placental villous tissue
Brockway, H. M.; Wilson, S. L.; Kallapur, S. G.; Buhimschi, C. S.; Muglia, L. J.; Jones, H.
10.1101/2021.04.26.441471 — physiology — Posted on 2022-03-22
1237 Cytosolic peptide accumulation activates the NLRP1 and CARD8 inflammasomes
Orth-He, E. L.; Huang, H.-C.; Rao, S. D.; Wang, Q.; Chen, Q.; O'Mara, C. M.; Chui, A. J.; Saoi, M.; Griswold, A. R.; Bhattacharjee, A.; Ball, D. P.; Cross, J. R.; Bachovchin, D. A.
10.1101/2022.03.22.485298 — immunology — Posted on 2022-03-22
1239 A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome
Hsiao, J. C.; Neugroschl, A. R.; Chui, A. J.; Taabazuing, C. Y.; Griswold, A. R.; Wang, Q.; Huang, H.-C.; Orth-He, E. L.; Ball, D. P.; Hiotis, G.; Bachovchin, D. A.
10.1101/2022.03.22.485305 — immunology — Posted on 2022-03-22
1243 Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?
Fraisse, C.; Le Moan, A.; Roux, C.; Dubois, G.; Daguin-Thiebaut, C.; Gagnaire, P.-A.; Viard, F.; Bierne, N.
10.1101/2022.03.22.485319 — evolutionary biology — Posted on 2022-03-22
1245 An E3 ligase network engages GCN1 to promote elongation factor-1α degradation on stalled ribosomes
Oltion, K.; Carelli, J. D.; Yang, T.; See, S. K.; Wang, H.-Y.; Kampmann, M.; Taunton, J.
10.1101/2022.03.21.485216 — cell biology — Posted on 2022-03-22
1246 Serum profiles of metabolomic and GDF-15 differentiate idiopathic pulmonary fibrosis from other interstital lung diseases: a preliminary study
Li, M.; Ren, H.; Liu, L.; Li, W.; Wang, Z.; Zhang, J.; Wang, X.; Hu, Y.; Zang, K.; An, Y.; Xu, Z.; Guo, Z.; Costabel, U.; Dai, H.; Zhang, X.; Wang, Z.
10.1101/2022.03.22.484740 — molecular biology — Posted on 2022-03-22
1247 Stage-specific gene and transcript dynamics in human male germ cells
Siebert-Kuss, L. M.; Krenz, H.; Tekath, T.; Wöste, M.; Di Persio, S.; Terwort, N.; Wyrwoll, M. J.; Cremers, J.-F.; Wistuba, J.; Dugas, M.; Kliesch, S.; Schlatt, S.; Tüttelmann, F.; Gromoll, J.; Neuhaus, N.; Laurentino, S.
10.1101/2022.03.22.485121 — molecular biology — Posted on 2022-03-22
1249 The NLRP1 and CARD8 inflammasomes detect reductive stress
Wang, Q.; Hsiao, J.; Yardeny, N.; Huang, H.-C.; O'Mara, C. M.; Orth-He, E. L.; Ball, D. P.; Bachovchin, D. A.
10.1101/2022.03.22.485209 — immunology — Posted on 2022-03-22
1250 Distinct gene programs underpinning 'disease tolerance' and 'resistance' in influenza virus infection
Cohn, O.; Yankovitz, G.; Peshes-Yaloz, N.; Steuerman, Y.; Frishberg, A.; Brandes, R.; Mandelboim, M.; R. Hamilton, J.; Hagai, T.; Amit, I.; G. Netea, M.; Hacohen, N.; A. Iraqi, F.; Bacharach, E.; Gat-Viks, I.
10.1101/2022.03.22.485254 — systems biology — Posted on 2022-03-22
1253 The wheat multi-pathogen resistance gene, Lr67res, confers a novel gain-of-function phenotype involving anion fluxes
Milne, R. J.; Dibley, K. E.; Bose, J.; Riaz, A.; Zhang, J.; Schnippenkoetter, W. H.; Ashton, A. R.; Ryan, P. R.; Tyerman, S. D.; Lagudah, E.
10.1101/2022.03.22.485337 — plant biology — Posted on 2022-03-22
1254 The Arabidopsis transcription factor NLP2 regulates early nitrate responses and integrates nitrate assimilation with energy and carbon skeleton supply
Durand, M.; Brehaut, V.; Clement, G.; Kelemen, Z.; Mace, J.; Feil, R.; Duville, G.; Launay-Avon, A.; Paysant-Le Roux, C.; Lunn, J. E.; Roudier, F.; Krapp, A.
10.1101/2022.03.21.485211 — plant biology — Posted on 2022-03-22
1258 Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
Maker, A.; Bolejack, M.; Schecterson, L.; Hammerson, B.; Abendroth, J.; Edwards, T. E.; Staker, B.; Myler, P. J.; Gumbiner, B. M.
10.1101/2022.03.21.484361 — biochemistry — Posted on 2022-03-22
1259 Live-cell RNA imaging with metabolically incorporated fluorescent nucleosides
Wang, D.; Shalamberidze, A.; Arguello, A. E.; Purse, B.; Kleiner, R. E.
10.1101/2022.03.22.485351 — biochemistry — Posted on 2022-03-22
1262 Persistent acetylation of newly synthesized histones inhibits DNA replication origin activity
Tremblay, R.; Merhjoo, Y.; Simoneau, A.; McQuaid, M.; Nislow, C.; Giaever, G.; Wurtele, H.
10.1101/2022.03.22.485257 — molecular biology — Posted on 2022-03-22
1263 Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Dreijerink, K. M. A.; Ozyerli-Goknar, E.; Koidl, S.; van der Lelij, E. J.; van den Heuvel, P.; Kooijman, J. J.; Biniossek, M. L.; Rodenburg, K. W.; Nizamuddin, S.; Timmers, H. T. M.
10.1101/2022.03.22.485279 — molecular biology — Posted on 2022-03-22
1266 A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimer
Sun, L.; Zhan, W.; Tian, X.; Zhang, X.; Xing, S.; Song, W.; Liu, Q.; Hao, A.; Hu, Y.; Zhang, M.; Chen, Z.; Ying, T.; Lan, F.
10.1101/2022.03.21.485243 — microbiology — Posted on 2022-03-22
1267 Humanized mice for sustained Plasmodium vivax blood-stage infection and transmission
Luiza-Batista, C.; Thiberge, S.; Serra-Hassoun, M.; Garcia, S.; Nardella, F.; Claes, A.; Nicolete, V. C.; Commere, P.-H.; Silva-Mancio, L.; Ferreira, M. U.; Scherf, A.; Garcia, S.
10.1101/2022.03.22.485265 — microbiology — Posted on 2022-03-22
1268 A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective immunity against the SARS-CoV-2 delta variant in transgenic K18-hACE2 mice
Brandys, P.; Montagutelli, X.; Merenkova, I.; Barut, G. T.; Thiel, V.; Schork, N. J.; Trüeb, B.; Conquet, L.; Deng, A.; Antanasijevic, A.; Lee, H.-K.; Valiere, M.; Sindhu, A.; Singh, G.; Herold, J.
10.1101/2022.03.21.485224 — immunology — Posted on 2022-03-22
1269 ACE2 is necessary for SARS-CoV-2 infection and sensing by macrophages but not sufficient for productive viral replication
Labzin, L. I.; Chew, K. Y.; Wang, X.; Esposito, T.; Stocks, C. J.; Rae, J.; Yordanov, T.; Holley, C. L.; Emming, S.; Fritzlar, S.; Mordant, F. L.; Steinfort, D. P.; Subbarao, K.; Lagendijk, A. K.; Parton, R.; Short, K. R.; Londrigan, S. L.; Schroder, K.
10.1101/2022.03.22.485248 — immunology — Posted on 2022-03-22
1271 Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation
Gonzalez-Menendez, P.; Phadke, I.; Olive, M. E.; McGraw, K. L.; Platon, J.; Papoin, J.; Yan, H.; Daumur, M.; Paul, F.; Mirmira, R.; Joly, A.; Galtier, J.; Narla, A.; Cartron, G.; Dardalhon, V.; Zimmermann, V. S.; Sitbon, M.; Dever, T. E.; Mohandas, N.; Costa, L. d.; Udeshi, N. D.; Blanc, L.; Kinet, S.; Taylor, N.
10.1101/2022.03.21.485053 — physiology — Posted on 2022-03-22
1273 Maximum likelihood pandemic-scale phylogenetics
De Maio, N.; Kalaghatgi, P.; Turakhia, Y.; Corbett-Detig, R.; Minh, B. Q.; Goldman, N.
10.1101/2022.03.22.485312 — bioinformatics — Posted on 2022-03-22
1274 Rapid genotyping of viral samples using Illumina short-read sequencing data
Varadi, A.; Kaszab, E.; Kardos, G.; Prepost, E.; Szarka, K.; Laczko, L.
10.1101/2022.03.21.485184 — bioinformatics — Posted on 2022-03-22
1276 Taxonomic and functional diversity of aquatic heterotrophs is sustained by dissolved organic matter chemodiversity
Garcia, S. L.; Nuy, J. K.; Mehrshad, M.; Hampel, J. J.; Sedano-Nunez, V. T.; Buck, M.; Divne, A.-M.; Lindström, E. S.; Petras, D.; Hawkes, J.; Bertilsson, S.
10.1101/2022.03.21.485019 — ecology — Posted on 2022-03-22
1277 Decoding trans-saccadic prediction error
Barne, L. C.; Giordano, J.; Collins, T.; Desantis, A.
10.1101/2022.03.21.485172 — neuroscience — Posted on 2022-03-22
1279 Dietary fibre deprivation and bacterial curli exposure shift gut microbiome and exacerbate Parkinson's disease-like pathologies in an alpha-synuclein-overexpressing mouse
Schmit, K. J.; Sciortino, A.; Aho, V. T.; Garcia, P.; Pardo Rodriguez, B.; Thomas, M. H.; Gerardy, J.-J.; Halder, R.; Cialini, C.; Heurtaux, T.; Bastero Acha, I.; Ostahi, I.; Martens, E. C.; Mittelbronn, M.; Buttini, M.; Wilmes, P.
10.1101/2022.03.21.485143 — neuroscience — Posted on 2022-03-22
1283 Three-dimensional multilayer concentric bipolar electrodes enhance the selectivity of optic nerve stimulation
Borda, E.; Gaillet, V.; Airaghi Leccardi, M. J.; Zollinger, E. G.; Moreira, R. C.; Ghezzi, D.
10.1101/2022.03.21.485100 — bioengineering — Posted on 2022-03-22
1285 Croatian Genetic Heritage: Renewed Y Chromosome Story a Decade Later
Primorac, D.; Skaro, V.; Projic, P.; Missoni, S.; Horjan Zanki, I.; Merkas, S.; Sarac, J.; Novokmet, N.; Ledic, A.; Makar, A.; Lauc, G.; Andelinovic, S.; Basic, Z.; Kruzic, I.; Neuberg, M.; Smolic, M.; Smolic, R.; Hrstic, I.; Trivanovic, D.; Konjhodzic, R.; Salihefendic, L.; Babic Jordamovic, N.; Marjanovic, D.
10.1101/2022.03.21.485134 — evolutionary biology — Posted on 2022-03-22
1286 Dynamic coastal pelagic habitat drives rapid changes in growth and condition of juvenile sockeye salmon (Oncorhynchus nerka) during early marine migration
Garzke, J.; Forster, I.; Godwin, S.; Johnson, B. T.; Krkosek, M.; Mahara, N.; Pakhomov, E. A.; Rogers, L. A.; Hunt, B. P.
10.1101/2022.03.21.484660 — ecology — Posted on 2022-03-22
1288 Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation
Küey, C.; Sittewelle, M.; Larocque, G.; Hernandez-Gonzalez, M.; Royle, S. J.
10.1101/2022.03.21.485220 — cell biology — Posted on 2022-03-22
1290 Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus-maze.
Hilton, J. R.; Simpson, S. R.; Sherman, E. R.; Raby-Smith, W.; Azvine, K.; Arribas, M.; Zhou, J.; Deiana, S.; Hengerer, B.; Cahill, E. N.
10.1101/2022.03.21.485161 — neuroscience — Posted on 2022-03-22
1293 The Phytophthora capsici RxLR effector CRISIS2 has roles in suppression of PTI and triggering cell death in host plant
Mang, H.; Seo, Y.-E.; Lee, H.-Y.; Kim, H.; Jeon, H.; Yan, X.; Lee, S.; Park, S. A.; Kim, M.-S.; Segonzac, C.; Choi, D.
10.1101/2022.03.21.485173 — plant biology — Posted on 2022-03-22
1295 Adipose mTORC2 is essential for arborization of sensory neurons in white adipose tissue and whole-body energy homeostasis
Frei, I. C.; Weissenberger, D.; Ritz, D.; Heusermann, W.; Colombi, M.; Shimobayashi, M.; Hall, M. N.
10.1101/2022.03.21.485116 — physiology — Posted on 2022-03-22
1299 Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus
Raasch, L.; Yamamoto, K.; Newman, C. M.; Rosinski, J. R.; Shepherd, P. M.; Razo, E.; Crooks, C. M.; Bliss, M. I.; Breitbach, M. E.; Sneed, E. L.; Weiler, A. M.; Zeng, X.; Noguchi, K. K.; Morgan, T. K.; Fuhler, N. A.; Bohm, E. K.; Alberts, A. J.; Havlicek, S. J.; Kabakov, S.; Mitzey, A. M.; Antony, K. M.; Ausderau, K. K.; Mejia, A.; Basu, P.; Simmons, H. A.; Eickhoff, J. C.; Aliota, M. T.; Mohr, E. L.; Friedrich, T. C.; Golos, T. G.; O'Connor, D. H.; Dudley, D. M.
10.1101/2022.03.21.485088 — pathology — Posted on 2022-03-22
1300 Nanoscale organization of the endogenous ASC speck
Glueck, I. M.; Mathias, G. P.; Strauss, S.; Ebert, T. S.; Stafford, C.; Agam, G.; Manley, S.; Hornung, V.; Jungmann, R.; Sieben, C.; Lamb, D. C.
10.1101/2021.09.17.460822 — immunology — Posted on 2022-03-22
1304 The little skate genome and the evolutionary emergence of wing-like fin appendages
Marletaz, F.; de la Calle-Mustienes, E.; Acemel, R. D.; Nakamura, T.; Paliou, C.; Naranjo, S.; Martinez-Garcia, P. M.; Cases, I.; Sleight, V. A.; Hirschberger, C.; Marcet-Houben, M.; Navon, D.; Andrescavage, A.; Skvortsova, K.; Duckett, P. E.; Gonzalez-Rajal, A.; Bogdanovic, O.; Gibcus, J. H.; Yang, L.; Gallardo-Fuentes, L.; Sospedra, I.; Lopez-Rios, J.; Darbellay, F.; Visel, A.; Dekker, J.; Shubin, N.; Gabaldon, T.; Tena, J. J.; Lupianez, D. G.; Rokhsar, D. S.; Gomez-Skarmeta, J. L.
10.1101/2022.03.21.485123 — evolutionary biology — Posted on 2022-03-22
1305 Automation of tree-ring detection and measurements using deep learning
Polacek, M.; Arizpe, A.; Hüther, P.; Weidlich, L.; Steindl, S.; Swarts, K.
10.1101/2022.01.10.475709 — ecology — Posted on 2022-03-22
1315 Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity and episodic memory
Coenjaerts, M.; Trimborn, I.; Adrovic, B.; Stoffel-Wagner, B.; Cahill, L.; Philipsen, A.; Hurlemann, R.; Scheele, D.
10.1101/2021.11.22.469500 — neuroscience — Posted on 2022-03-22
1317 Spatial Patterns of Microbial Diversity, Composition and Community Structure in Fe-Mn Deposits and Associated Sediments in the Atlantic and Pacific Oceans
Bergo, N. M.; Ballesteros, A. T.; Signori, C. N.; Benites, M.; Jovane, L.; Murton, B. J.; Rocha, U. N. d.; Pellizari, V. H.
10.1101/2022.03.21.485154 — microbiology — Posted on 2022-03-22
1318 Macrophage-derived VEGF-C decreases hematogenous metastatic dissemination by normalizing the tumor vasculature
Ferreira, S. d. S.; Wallmann, T.; Kerzel, T.; Wallerius, M.; Bartish, M.; Landwehr, L. S.; Pan, Y.; Agardy, D. A.; Bergh, J.; Hartman, J.; Squadrito, M. L.; Rolny, C.
10.1101/2022.01.26.468593 — cancer biology — Posted on 2022-03-22
1320 Compendium of secondary metabolite biosynthetic diversity encoded in bacterial genomes
Gavriilidou, A.; Kautsar, S. A.; Zaburannyi, N.; Krug, D.; Mueller, R.; Medema, M. H.; Ziemert, N.
10.1101/2021.08.11.455920 — genomics — Posted on 2022-03-22
1321 Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis
Astre, G.; Atlan, T.; Goshtchevsky, U.; Shapira, K.; Oron-Gottesman, A.; Levy, T.; Velan, A.; Smirnov, M.; Deelen, J.; Levanon, E. Y.; Harel, I.
10.1101/2022.01.10.475524 — genetics — Posted on 2022-03-22
1323 Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern
Pollet, J.; Strych, U.; Chen, W.-H.; Versteeg, L.; Keegan, B.; Zhan, B.; Wei, J.; Liu, Z.; Lee, J.; Kundu, R.; Adhikari, R.; Poveda, C.; Villar, M. J.; Thimmiraju, S. R.; Lopez, B.; Gillespie, P. M.; Ronca, S.; Kimata, J. T.; Reers, M.; Paradkar, V.; Hotez, P.; Bottazzi, M. E.
10.1101/2021.07.06.451353 — molecular biology — Posted on 2022-03-22
1324 N-VEGF, the autoregulatory arm of VEGF-A
Katsman, M.; Azriel, A.; Horev, G.; Reizel, Y.; Levi, B.-Z.
10.1101/2021.07.25.453721 — molecular biology — Posted on 2022-03-22
1326 Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis
Smith, T. M.; Youngblom, M. A.; Kernien, J. F.; Mohamed, M. A.; Fry, S. S.; Bohr, L. L.; Mortimer, T. D.; O'Neill, M. B.; Pepperell, C. S.
10.1101/2021.04.08.439010 — microbiology — Posted on 2022-03-22
1328 Impaired iron recycling from erythrocytes is an early iron-dependent hallmark of aging
Slusarczyk, P.; Mandal, P. K.; Zurawska, G.; Niklewicz, M.; Kumari Chouhan, K.; Cybulska, M.; Krawczyk, O.; Herman, S.; Mikula, M.; Serwa, R.; Lenartowicz, M.; Pokrzywa, W.; Mleczko-Sanecka, K.
10.1101/2022.01.16.476518 — physiology — Posted on 2022-03-22
1332 Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages
Modabbernia, A.; Vidal-Pineiro, D.; Agartz, I.; Andreassen, O. A.; Ayesa-Arriola, R.; Bertolino, A.; Boomsma, D. I.; Bourque, J.; Breier, A.; Brouwer, R. M.; Buitelaar, J. K.; Canales-Rodriguez, E. J.; Caseras, X.; Conrod, P. J.; Crespo-Facorro, B.; Crivello, F.; Crone, E. A.; de Zubicaray, G. I.; Dickie, E. W.; Dima, D.; Frenzel, S.; Fisher, S. E.; Franke, B.; Glahn, D. C.; Grabe, H.-J.; Grotegerd, D.; Gruber, O.; Guerrero-Pedraza, A.; Gur, R. E.; Gur, R. C.; Hartman, C. A.; Hoekstra, P. J.; Hulshoff Pol, H. E.; Jahanshad, N.; Jernigan, T. L.; Jiang, J.; Kalnin, A. J.; Kochan, N. A.; Mazoyer,
10.1101/2022.03.21.484899 — neuroscience — Posted on 2022-03-22
1334 Nr6a1 controls axially-restricted body elongation, segmentation, patterning and lineage allocation
McGlinn, E.; Chang, Y.-C.; Wong, S. F. L.; Schroeder, J.; Hauswirth, G. M.; Shylo, N. A.; Moore, E. L.; Achilleos, A.; Garside, V.; Polo, J. M.; Manent, J.; Trainor, P.
10.1101/2022.03.21.485239 — developmental biology — Posted on 2022-03-22
1336 Dynamic proteomic and phosphoproteomic atlas of corticostriatal axon neurodevelopment
Dumrongprechachan, V.; Salisbury, R.; Butler, L.; MacDonald, M. L.; Kozorovitskiy, Y.
10.1101/2022.03.21.485234 — neuroscience — Posted on 2022-03-22
1342 Single-cell analyses of axolotl forebrain organization, neurogenesis, and regeneration
Lust, K.; Maynard, A.; Gomes, T.; Fleck, J. S.; Camp, J. G.; Tanaka, E. M.; Treutlein, B.
10.1101/2022.03.21.485045 — developmental biology — Posted on 2022-03-22
1344 Proteasomal subunit depletions differentially affect germline integrity in C. elegans
Fernando, L. M.; Quesada-Candela, C.; Murray, M.; Ugoaru, C.; Yanowitz, J. L.; Allen, A. K.
10.1101/2022.03.21.485201 — developmental biology — Posted on 2022-03-22
1347 Genomic insights into the evolutionary relationships and demographic history of kiwi
Westbury, M. V.; De Cahsan, B.; Shepherd, L. D.; Holdaway, R.; Duchene, D.; Lorenzen, E.
10.1101/2022.03.21.485235 — evolutionary biology — Posted on 2022-03-21
1350 Complete chloroplast genomes and phylogeny in three Euterpe palms (E. edulis, E. oleraceae and E. precatoria) from different Brazilian biomes
Francisconi, A. F.; dos Santos, L. A. C.; Morales Marroquin, J. A.; van den Berg, C.; Alves-Pereira, A.; Delmondes de Alencar, L.; Picanco-Rodrigues, D.; Zanello, C. A.; Ferreira Costa, M.; Gomes Lopes, M. T.; Veasey, E. A.; Zucchi, M. I.
10.1101/2022.03.21.485093 — evolutionary biology — Posted on 2022-03-21
1351 HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD
Horndahl, J.; Svärd, R.; Berntsson, P.; Wingren, C.; Li, J.; Abdillahi, S. M.; Ghosh, B.; Capodanno, E.; Chan, J.; Ripa, L.; Astrand, A.; Sidhaye, V. K.; Collins, M.
10.1101/2022.03.21.485098 — cell biology — Posted on 2022-03-21
1355 The addition of FAIMS Increases Targeted Proteomics Sensitivity from FFPE Tumor Biopsies
Sweet, S. M.; Chain, D.; Yu, W.; Martin, P.; Rebelatto, M.; Chambers, A.; Cecchi, F.; Kim, Y. J.
10.1101/2022.02.08.479554 — cancer biology — Posted on 2022-03-21
1358 Three-dimensional structure of the single domain cupredoxin AcoP
Roger, M.; Leone, P.; Blackburn, N.; Horrel, S.; Chicano, T. M.; Giudici-Orticoni, M.-T.; Abriata, L. A.; Hura, G. L.; Hough, M. A.; Sciara, G.; Ilbert, M.
10.1101/2022.03.21.484586 — biophysics — Posted on 2022-03-21
1362 Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector
Ibrahim, S. S.; Muhammad, A.; Hearn, J.; Weedall, G. D.; Nagi, S. C.; Mukhtar, M. M.; Fadel, A. N.; Mugenzi, L. M. J.; Patterson, E. I.; Irving, H.; Wondji, C. S.
10.1101/2022.03.21.485146 — genomics — Posted on 2022-03-21
1365 Systematic analysis of YFP gene traps reveals common discordance between mRNA and protein across the nervous system
Titlow, J. S.; Kiourlappou, M.; Palanca, A.; Lee, J. Y.; Gala, D. S.; Ennis, D.; Yu, J. J. S.; Young, F. L.; Pinto, D. M. S.; Garforth, S.; Francis, H. S.; Strivens, F.; Mulvey, H.; Dallman-Porter, A.; Thornton, S.; Arman, D.; Järvelin, A. I.; Thompson, M. K.; Kounatidis, I.; Parton, R. M.; Taylor, S.; Davis, I.
10.1101/2022.03.21.485142 — cell biology — Posted on 2022-03-21
1367 Unexpected growth of a classic yeast auxotroph
Van Oss, S. B.; Parikh, S. B.; Coelho, N. C.; Wacholder, A.; Belashov, I.; Michaca, M.; Xu, J.; Kang, Y. P.; McCourt, K. M.; McKee, J.; Ideker, T.; VanDemark, A. P.; DeNicola, G. M.; Carvunis, A.-R.
10.1101/2022.01.19.476918 — molecular biology — Posted on 2022-03-21
1372 Environmental and genetic disease modifiers of haploinsufficiency of A20
Zammit, N. N.; Gray, P.; Siggs, O. M.; Yap, J. Y.; Russell, A.; Cultrone, D.; Warren, J.; Walters, S. N.; Brink, R. T.; Zahra, D.; Burnett, D. L.; Gayevskiy, V.; Minoche, A. E.; Ziegler, J. B.; Craig, M. E.; Wong, M.; Benitez-Aguirre, P.; Teo, J.; Cowley, M. J.; Dinger, M. E.; Tangye, S. G.; Burk, C.; Phan, T. G.; Goodnow, C. J.; Grey, S. T.
10.1101/2022.03.19.485004 — immunology — Posted on 2022-03-21
1374 A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4
Gawish, R.; Maier, B.; Obermayer, G.; Watzenboeck, M.; Gorki, A.-D.; Quattrone, F.; Farhat, A.; Lakovits, K.; Hladik, A.; Korosec, A.; Alimohammadi, A.; Mesteri, I.; Oberndorfer, F.; Oakley, F.; Brain, J.; Boon, L.; Lang, I.; Binder, C.; Knapp, S.
10.1101/2022.03.21.485114 — immunology — Posted on 2022-03-21
1375 Polypyrimidine Tract-Binding Protein 1 (PTBP1) regulates CD4 T cell Activation independent of its role in proliferation
Narayanan, B.; Prado De Maio, D.; La Porta, J.; Voskoboynik, Y.; Matus-Nicodemos, R.; Summers, S.; Ganapathi, U.; Valentin-Acevedo, A.; Covey, L. R.
10.1101/2022.03.21.485057 — immunology — Posted on 2022-03-21
1377 24-nt phasiRNAs move from tapetal to meiotic cells in maize anthers
Zhou, X.; Huang, K.; Teng, C.; Abdelgawad, A.; Batish, M.; Meyers, B. C.; Walbot, V.
10.1101/2021.08.24.457464 — plant biology — Posted on 2022-03-21
1378 Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria
Henry, B.; Volle, G.; Akpovi, H.; Gineau, L.; Roussel, C.; Ndour, P. A.; Tossou, F.; Suarez, F.; Palstra, F.; Fricot, A.; Chambrion, C.; Solinc, J.; Nguyen, J.; Gare, M.; Aussenac, F.; Cottart, C. H.; Keyser, C.; Adamou, R.; Tichit, M.; Hardy, D.; Fievet, N.; Clain, J.; Garcia, A.; Courtin, D.; Hermine, O.; Sabbagh, A.; Buffet, P.
10.1101/2022.03.21.485136 — physiology — Posted on 2022-03-21
1379 Multi-modal Imaging of Disease Progression in TH-MYCN Mouse Models of Neuroblastoma
Badachhape, A. A.; Tao, L.; Joshi, S.; Starosolski, Z. A.; Devkota, L.; Sarkar, P.; Bhandari, P.; Annapragada, A. A.; Barbieri, E.; Ghaghada, K.
10.1101/2022.03.21.484628 — cancer biology — Posted on 2022-03-21
1380 The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity
Ho, P.; Melms, J. C.; Rogava, M.; Frangieh, C. J.; Shah, S. B.; Walsh, Z.; Kyrysyuk, O.; Amin, A. D.; Caprio, L.; Fullerton, B. T.; Soni, R.; Ager, C. R.; Biermann, J.; Wang, Y.; Mu, M.; Fatima, H.; Moore, E. K.; Vasan, N.; Bakhoum, S. F.; Reiner, S. L.; Bernatchez, C.; Mace, E. M.; Wucherpfennig, K. W.; Schadendorf, D.; Schwartz, G. K.; Izar, B.
10.1101/2022.03.21.485049 — cancer biology — Posted on 2022-03-21
1383 Compact engineered human transactivation modules enable potent and versatile synthetic transcriptional control
Mahata, B.; Li, J.; Cabrera, A.; Brenner, D. A.; Guerra-Resendez, R. S.; Goell, J.; Wang, K.; Escobar, M.; Guo, Y.; Parthasarathy, A. K.; Hilton, I. B.
10.1101/2022.03.21.485228 — bioengineering — Posted on 2022-03-21
1384 Irc3 of the thermotolerant yeast Ogataea polymorpha is a branched-DNA-specific mitochondrial helicase
Piljukov, V. J.; Sedman, T.; Sillamaa, S.; Garber, N.; Ratsep, M.; Freiberg, A.; Sedman, J.
10.1101/2022.03.21.485104 — biochemistry — Posted on 2022-03-21
1387 Performance evaluation of three DNA sample tracking tools in a whole exome sequencing workflow
Wils, G.; Helmoortel, C.; Volders, P.-J.; Vereecke, I.; Milazzo, M. A.; Vandesompele, J.; Coppieters, F.; De Leeneer, K.; Lefever, S.
10.1101/2022.01.11.475818 — genomics — Posted on 2022-03-21
1388 A framework for evaluating edited cell libraries created by massively parallel genome engineering
Cawley, S.; Abbate, E.; Abraham, C. G.; Alvarez, S.; Barber, M.; Bolte, S.; Bruand, J.; Church, D. M.; Davis, C.; Estes, M.; Federowicz, S.; Fox, R.; Gander, M. W.; Garst, A. D.; Gencer, G.; Halweg-Edwards, A. L.; Hardenbol, P.; Hraha, T.; Jain, S.; Johnson, C.; Juneau, K.; Krishnamurthy, N.; Lambert, S.; Leland, B.; Pearson, F.; Ray, J. C. J.; Sanada, C. D.; Shaver, T. M.; Shepherd, T. R.; Shorenstein, J.; Spindler, E. C.; Struble, C. A.; Swat, M. H.; Tanner, S.; Tian, T.; Wishart, K.; Graige, M. S.
10.1101/2021.09.23.458228 — genomics — Posted on 2022-03-21
1389 Genomic insights into metabolic flux in ruby-throated hummingbirds
Gershman, A.; Hauck, Q.; Dick, M.; Jamison, J. M.; Tassia, M.; Agirrezabala, X.; Muhammad, S.; Ali, R.; Workman, R. E.; Valle, M.; Wong, G. W.; Welch, K. C.; Timp, W.
10.1101/2022.03.21.485221 — genomics — Posted on 2022-03-21
1390 Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals
Du, W.; Wang, J.; Kuo, T.; Wang, L.; McKimpson, W.; Son, J.; Watanabe, H.; Kitamoto, T.; Yunkyoung, L.; Ratner, L.; McCune, K.; Chen, Y.-W.; Grubbs, B.; Thornton, M.; Fan, J.; Sultana, N.; Diaz, B.; Balasubramanian, I.; Gao, N.; Belvedere, S.; Accili, D.
10.1101/2022.03.21.484748 — cell biology — Posted on 2022-03-21
1391 Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.
Yenilmez, B.; Kelly, M.; Zhang, G.-F.; Wetoska, N.; Ilkayeva, O.; Min, K.; Rowland, L.; DiMarzio, C.; He, W.; Raymond, N.; Lifshitz, L.; Pan, M.; Han, X.; Xie, J.; Friedline, R. H.; Kim, J. K.; Gao, G.; Herman, M. A.; Newgard, C.; Czech, M.
10.1101/2022.03.21.485183 — molecular biology — Posted on 2022-03-21
1392 Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in Podospora anserina
Warnsmann, V.; Marschall, L.-M.; Meessen, A. C.; Wolters, M.; Schuermanns, L.; Basoglu, M.; Eimer, S.; Osiewacz, H. D.
10.1101/2022.03.21.485166 — molecular biology — Posted on 2022-03-21
1393 Humoral and cellular immune memory to four COVID-19 vaccines
Zhang, Z.; Mateus, J.; Coelho, C. H.; Dan, J. M.; Moderbacher, C. R.; Galvez, R. I.; Cortes, F. H.; Grifoni, A.; Tarke, A.; Chang, J.; Escarrega, E. A.; Kim, C.; Goodwin, B.; Bloom, N. I.; Frazier, A.; Weiskopf, D.; Sette, A.; Crotty, S.
10.1101/2022.03.18.484953 — immunology — Posted on 2022-03-21
1395 Infant brain regional cerebral blood flow dynamics supporting emergence of vital functional networks
Yu, Q.; Ouyang, M.; Detre, J. A.; Kang, H.; Hu, D.; Hong, B.; Fang, F.; Peng, Y.; Huang, H.
10.1101/2021.02.08.430158 — neuroscience — Posted on 2022-03-21
1397 Optogenetic actuator/ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics
Dessauges, C.; Mikelson, J.; Dobrzynski, M.; Jacques, M.-A.; Frismantiene, A.; Gagliardi, P. A.; Khammash, M.; Pertz, O.
10.1101/2021.07.27.453955 — systems biology — Posted on 2022-03-21
1398 Deep topographic proteomics of a human brain tumour
Davis, S.; Scott, C.; Oetjen, J.; Charles, P. D.; Kessler, B. M.; Ansorge, O.; Fischer, R.
10.1101/2022.03.21.485119 — cancer biology — Posted on 2022-03-21
1399 Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools
Götz, M.; Barth, A.; Bohr, S. S.- R.; Börner, R.; Chen, J.; Cordes, T.; Erie, D. A.; Gebhardt, C.; Hadzic, M. C. A. S.; Hamilton, G. L.; Hatzakis, N. S.; Hugel, T.; Kisley, L.; Lamb, D. C.; de Lannoy, C.; Mahn, C.; Dunukara, D.; de Ridder, D.; Sanabria, H.; Schimpf, J.; Seidel, C. A. M.; Sigel, R. K. O.; Sletfjerding, M. B.; Thomsen, J.; Vollmar, L.; Wanninger, S.; Weninger, K. R.; Xu, P.; Schmid, S.
10.1101/2021.11.23.469671 — biophysics — Posted on 2022-03-21
1402 Identification of a Novel SARS-CoV-2 Delta-Omicron Recombinant Virus in the United States
Lacek, K. A.; Rambo-Martin, B.; Batra, D.; Zheng, X.-y.; Keller, M. W.; Wilson, M.; Sheth, M.; Davis, M.; Burroughs, M.; Gerhart, J.; Hassell, N.; Lee, J.; Shepard, S. S.; Cook, P. W.; Wentworth, D. E.; Barnes, J. R.; Kondor, R.; Paden, C. R.; Peacock, T. P. R.; Sakaguchi, H.
10.1101/2022.03.19.484981 — genomics — Posted on 2022-03-21
1404 Exon7 Targeted CRISPR-Prime Editing Approaches for SMN2 Gene Editing in Spinal Muscular Atrophy (SMA) Disease Can Increase In Vitro SMN Expression
Odabas, S. P.; Bal, E.; Yelgen, G.; Metin, A. S.; Karakaya, E.; Gulden, G.; Sert, B.; Teymur, T.; Ay, Y.; Tiryaki, N. N.; Aras, H.; Cavrar, I.; Tastan, C.
10.1101/2022.03.21.484406 — genetics — Posted on 2022-03-21
1405 Leveraging shared ancestral variation to detect local introgression
Lopez Fang, L.; Ortega-Del Vecchyo, D.; McTavish, E. J.; Huerta-Sanchez, E.
10.1101/2022.03.21.485082 — evolutionary biology — Posted on 2022-03-21
1407 Phase separation of hnRNP A1 upon specific RNA-binding observed by magnetic resonance
Ritsch, I.; Lehmann, E.; Emmanouilidis, L.; Yulikov, M.; Allain, F.; Jeschke, G.
10.1101/2022.03.21.485092 — molecular biology — Posted on 2022-03-21
1408 Toxoplasma gondii ROP1 subverts murine and human innate immune restriction
Butterworth, S.; Torelli, F.; Lockyer, E. J.; Wagener, J.; Song, O.-R.; Broncel, M.; Russell, M.; Young, J. C.; Treeck, M.
10.1101/2022.03.21.485090 — microbiology — Posted on 2022-03-21
1411 Transcriptomic response to ISAV infection in the gills, head kidney and spleen of resistant and susceptible Atlantic salmon
Gervais, O.; Papadopoulou, A.; Gratacap, R.; Hillestad, B.; Tinch, A.; Martin, S. A.; Houston, R. D.; Robledo, D.
10.1101/2022.03.21.485193 — genomics — Posted on 2022-03-21
1413 A conserved mechanism regulates reversible amyloids via pH-sensing regions
Cereghetti, G.; Kissling, V. M.; Koch, L. M.; Arm, A.; Afanasyev, P.; Linsenmeier, M.; Eichmann, C.; Zhou, J.; Cao, Y.; Pfizenmaier, D. M.; Kroschwald, S.; Wiegand, T.; Cadalbert, R.; Boehringer, D.; Mezzenga, R.; Arosio, P.; Riek, R.; Peter, M.
10.1101/2022.03.21.484600 — cell biology — Posted on 2022-03-21
1416 Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity
Victor, M. B.; Leary, N.; Luna, X.; Meharena, H. S.; Bozzelli, P. L.; Samaan, G.; Murdock, M. H.; von Maydell, D.; Effenberger, A. H.; Cerit, O.; Wen, H.-L.; Liu, L.; Welch, G.; Bonner, M.; Tsai, L.-H.
10.1101/2022.03.21.484146 — neuroscience — Posted on 2022-03-21
1418 Identification of BAHD acyltransferases associated with acylinositol biosynthesis in Solanum quitoense (naranjilla)
Leong, B. J.; Hurney, S. M.; Fiesel, P. D.; Anthony, T. M.; Moghe, G. D.; Jones, A. D.; Last, R. L.
10.1101/2022.03.21.485185 — plant biology — Posted on 2022-03-21
1422 The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells
Vipat, S.; Gupta, D.; Jonchhe, S.; Anderspuk, H.; Rothenberg, E.; Moiseeva, T. N.
10.1101/2022.03.21.485102 — cell biology — Posted on 2022-03-21
1424 Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits
MacDougald, O.; Li, Z.; Bowers, E.; Zhu, J.; Yu, H.; Hardij, J.; Bagchi, D. P.; Mori, H.; Lewis, K. T.; Granger, K.; Schill, R. L.; Romanelli, S. M.; Abrishami, S.; Hankenson, K. D.; Singer, K.; Rosen, C. J.
10.1101/2022.03.21.485120 — cell biology — Posted on 2022-03-21
1425 BIN1/Amphiphysin 2 and ezrin drive filopodia-like structures in myoblasts
Picas, L.; Comunale, F.; Andre-Arpin, C.; Bousquet, H.; Tsai, F.-C.; Rico, F.; Maiuri, P.; Pernier, J.; Bodin, S.; Laporte, J.; Bassereau, P.; Goud, B.; Gauthier-Rouviere, C.; Miserey-Lenkei, S.
10.1101/2022.03.21.485158 — cell biology — Posted on 2022-03-21
1427 Genome mining, phylogenetic, and functional analysis of arsenic (As) resistance operons in Bacillus strains, isolated from As-rich hot spring microbial mats
Flores, A.; Valencia-Marin, M. F.; Chavez-Avila, S.; Ramirez-Diaz, M. I.; de los Santos Villalobos, S.; Meza-Carmen, V.; Orozco Mosqueda, M. d. C.; Santoyo, G.
10.1101/2022.03.20.485026 — microbiology — Posted on 2022-03-21
1428 Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
Mahajan, G.; Doherty, E.; To, T.; Sutherland, A.; Grant, J.; Junaid, A.; Gulati, A.; LoGrande, N. T.; Izadifar, Z.; Timilsina, S. S.; Horvath, V.; Plebani, R.; France, M.; Hood-Pishchany, I.; Rakoff-Nahoum, S.; Kwon, D. S.; Goyal, G.; Prantil-Baun, R.; Ravel, J.; Ingber, D. E.
10.1101/2022.03.20.485048 — microbiology — Posted on 2022-03-21
1431 Reversible edema following electric drilling of macaque craniotomy
Boshra, R.; Eradath, M.; Dougherty, K.; Wu, B.; Morea, B. M.; Pinsk, M.; Kastner, S.
10.1101/2022.03.19.484963 — neuroscience — Posted on 2022-03-21
1432 The neural code behind real-world recognition abilities
Faghel-Soubeyrand, S.; Ramon, M.; Bamps, E.; Zoia, M.; Woodhams, J.; Richoz, A.-R.; Caldara, R.; Gosselin, F.; Charest, I.
10.1101/2022.03.19.484245 — neuroscience — Posted on 2022-03-21
1433 Stroke disconnectome decodes reading networks
Forkel, S. J.; Labache, L.; Nachev, P.; Thiebaut de Schotten, M.; Hesling, I.
10.1101/2022.03.20.485029 — neuroscience — Posted on 2022-03-21
1436 Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2
Anglero-Rodriguez, Y. I.; Lempp, F. A.; McIninch, J.; Schlegel, M. K.; Brown, C. R.; Foster, D. J.; Castoreno, A. B.; Nguyen, T.; Subramanian, M.; Montiel-Ruiz, M.; Kaiser, H.; Sahakyan, A.; Spreafico, R.; Morskaya, S. S.; Barry, J. D.; Berman, D.; Lefebvre, S.; Kasper, A.; Racie, T.; Weddle, D.; Mobley, M.; Rogers, A.; Dybowski, J.; Chong, S.; Nair, J.; Simon, A.; Sloan, K.; Hwang, S.; Virgin, H. W.; Fitzgerald, K.; Maier, M. A.; Hinkle, G.; Hebner, C.; Akinc, A.; Jadhav, V.
10.1101/2022.03.20.485044 — pharmacology and toxicology — Posted on 2022-03-21
1437 Short-term and bystander effects of radiation on murine submandibular glands
Uchida, H.; Ingalls, M. H.; Maruyama, E. O.; Johnston, C. J.; Hernady, E.; Faustoferri, R. C.; Ovitt, C. E.
10.1101/2022.03.20.484987 — cancer biology — Posted on 2022-03-21
1440 Syrah, a Slide-seqV2 pipeline augmentation
Brewster, C. E.; Mann, F. G.; Benham-Pyle, B. W.; Sanchez Alvarado, A.
10.1101/2022.03.20.485023 — bioinformatics — Posted on 2022-03-21
1443 Dual spatially resolved transcriptomics for SARS-CoV-2 host-pathogen colocalization studies in humans
Sounart, H.; Lazar, E.; Masarapu, Y.; Wu, J.; Varkonyi, T.; Glasz, T.; Kiss, A.; Borgström, E.; Hill, A.; Jurek, A.; Niesnerova, A.; Druid, H.; Bergmann, O.; Giacomello, S.
10.1101/2022.03.14.484288 — genomics — Posted on 2022-03-21
1444 A genome-wide mutational constraint map quantified from variation in 76,156 human genomes
Chen, S.; Francioli, L.; Goodrich, J.; Collins, R.; Wang, Q.; Alfoldi, J.; Watts, N.; Vittal, C.; Gauthier, L.; Poterba, T.; Wilson, M.; Tarasova, Y.; Phu, W.; Yohannes, M.; Koenig, Z.; Farjoun, Y.; Banks, E.; Donnelly, S.; Gabriel, S.; Gupta, N.; Ferriera, S.; Tolonen, C.; Novod, S.; Bergelson, L.; Roazen, D.; Ruano-Rubio, V.; Covarrubias, M.; Llanwarne, C.; Petrillo, N.; Wade, G.; Jeandet, T.; Munshi, R.; Tibbetts, K.; gnomAD Project Consortium, ; O'Donnell-Luria, A.; Solomonson, M.; Seed, C.; Martin, A.; Talkowski, M.; Rehm, H.; Daly, M.; Tiao, G.; Neale, B.; MacArthur, D.; Karczewski, K.
10.1101/2022.03.20.485034 — genetics — Posted on 2022-03-21
1447 Stem cells partner with matrix remodeling cells during regeneration
Benham-Pyle, B. W.; Mann, F. G.; Brewster, C. E.; Dewars, E. R.; Nowotarski, S. H.; Guerrero-Hernandez, C.; Malloy, S.; Hall, K. E.; Maddera, L. E.; Chen, S.; Morrison, J. A.; Slaughter, B. D.; Perera, A.; Alvarado, A. S.
10.1101/2022.03.20.485025 — developmental biology — Posted on 2022-03-21
1448 CMLD-2 Attenuates Myofibroblast Activation and Bleomycin-Induced Pulmonary Fibrosis in Mice through Antagonizing ELAVL1-Mediated Osteopontin mRNA Stabilization
Guo, Q.; Ren, H.; Li, M.; Liu, L.; Li, W.; Zhang, J.; Wang, X.; Hu, Y.; Zang, K.; An, Y.; Li, L.; Wei, L.; Xu, Z.; Guo, Z.; Costabel, U.; Zhang, X.; Zheng, W.
10.1101/2022.03.20.484975 — molecular biology — Posted on 2022-03-21
1449 High neutralizing antibody levels against SARS-CoV-2 Omicron after UB-612 booster vaccination
Guirakhoo, F.; Wang, S.; Wang, C. Y.; Kuo, H.-K.; Peng, W.-J.; Liu, H.; Wang, L.; Johnson, M.; Hunt, A.; Hu, M. M.; Monath, T. P.; Rumyantsev, A.; Goldblatt, D.
10.1101/2022.03.18.484436 — microbiology — Posted on 2022-03-21
1452 Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19.
Jang, H.; Choudhury, S.; Yu, Y.; Sievers, B. L.; Gelbart, T.; Singh, H.; Rawlings, S. A.; Tan, G. S.; Smith, D.; Freire, M.
10.1101/2022.03.18.484814 — immunology — Posted on 2022-03-21
1455 Discovering dynamical models of human behavior
Jaffe, P. I.; Poldrack, R. A.; Schafer, R. J.; Bissett, P. G.
10.1101/2022.03.20.484666 — neuroscience — Posted on 2022-03-21
1458 Target-agnostic discovery of Rett Syndrome therapeutics by coupling computational network analysis and CRISPR-enabled in vivo disease modeling
Novak, R.; Lin, T.; Kaushal, S.; Sperry, M. M.; Vigneault, F.; Gardner, E.; Loomba, S.; Shcherbina, K.; Keshari, V.; Dinis, A.; Vasan, A.; Chandrasekhar, V.; Takeda, T.; Turner, J. R.; Levin, M.; Ingber, D. E.
10.1101/2022.03.20.485056 — neuroscience — Posted on 2022-03-21
1461 Treatment response prediction: Is model selection unreliable?
Augustin, D.; Walz, A.-C.; Wang, K.; Lambert, B.; Clerx, M.; Robinson, M.; Gavaghan, D.
10.1101/2022.03.19.483454 — systems biology — Posted on 2022-03-21
1462 Hybrid conferences: opportunities, challenges and ways forward
Puccinelli, E.; Zeppilli, D.; Stefanoudis, P.; Wittische-Helou, A.; Kermorgant, M.; Fuchs, S.; Sarrazin, J.; Easton, E. E.; Weber, A. A.-T.
10.1101/2022.03.18.484941 — scientific communication and education — Posted on 2022-03-21
1463 Liguleless narrow and narrow odd dwarf act in overlapping pathways to regulate maize development & physiology
Abraham-Juarez, M. J.; Busche, M.; Anderson, A. A.; Lunde, C.; Winders, J.; Christensen, S. A.; Hunter, C. T.; Hake, S.; Brunkard, J. O.
10.1101/2022.03.20.485070 — plant biology — Posted on 2022-03-21
1466 Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort.
Khamis, A.; Ning, L.; Balkau, B.; Bonnefond, A.; Canouil, M.; Roussel, R.; Froguel, P.
10.1101/2022.03.18.484909 — genomics — Posted on 2022-03-21
1469 Screening of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis
Lai, Y.; Tuvim, M.; Pfuetzner, R.; Esquivies, L.; Zhou, Q.; Czako, B.; Cross, J.; Jones, P.; Dickey, B.; Brunger, A. T.
10.1101/2022.03.21.484632 — pharmacology and toxicology — Posted on 2022-03-21
1474 Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice.
Sanz-Ros, J.; Mas-Bargues, C.; Monleon, D.; Gordevicius, J.; Brooke, R. T.; Dromant, M.; Derevyanko, A.; Guio-Carrion, A.; Roman-Dominguez, A.; Romero-Garcia, N.; Ingles, M.; Blasco, M. A.; Horvath, S.; Vina, J.; Borras, C.
10.1101/2021.07.29.454302 — physiology — Posted on 2022-03-21
1475 Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy
Hsu, S.-N.; Stephen, L. A.; Dillon, S.; Milne, E.; Javaheri, B.; Pitsillides, A. A.; Novak, A.; Millan, J. L.; Macrae, V. E.; Staines, K. A.; Farquharson, C.
10.1101/2021.08.06.455411 — molecular biology — Posted on 2022-03-21
1476 Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA
Shema Mugisha, C.; Dinh, T.; Kumar, A.; Tenneti, K.; Eschbach, J. E.; Davis, K.; Gifford, R.; Kvaratskhelia, M.; Kutluay, S.
10.1101/2021.12.16.472884 — microbiology — Posted on 2022-03-21
1479 Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair
Kim, M.; Kim, H. S.; D'Souza, A.; Gallagher, K.; Jeong, E.; Topolska-Wos, A.; Ogorodnik Le Meur, K.; Tsai, C.-L.; Tsai, M.-S.; Kee, M.; Tainer, J. A.; Yeo, J.-E.; Chazin, W. J.; Scharer, O. D.
10.1101/2022.03.01.482439 — biochemistry — Posted on 2022-03-21
1483 Reorganization of F-actin nanostructures is required for the late phases of SARS-CoV-2 replication in pulmonary cells.
Swain, J.; Merida, P.; Rubio, K.; Bracquemond, D.; Aguilar-Ordonez, I.; Guenther, S.; Barreto, G.; Muriaux, D.
10.1101/2022.03.08.483451 — microbiology — Posted on 2022-03-21
1484 Maternal separation induces autism spectrum disorder in young rhesus monkeys
Ren, X.-F.; Wu, S.-H.; Zhou, H.; Lv, L.-B.; Qiu, Z.-L.; Feng, X.-L.; Hu, X.-T.
10.1101/2022.03.17.484827 — neuroscience — Posted on 2022-03-21
1485 Structural and functional network-level reorganization in the coding of auditory motion directions and sound source locations in the absence of vision
Battal, C.; Gurtubay-Antolin, A.; Rezk, M.; Mattioni, S.; Bertonati, G.; Occelli, V.; Bottini, R.; Targher, S.; Maffei, C.; Jovicich, J.; Collignon, O.
10.1101/2021.07.28.454106 — neuroscience — Posted on 2022-03-21
1486 Configurable Compartmentation Enables In vitro Reconstitution of Sustained Synthetic Biology Systems
Li, L.; Zhang, R.; Tian, X.; Li, T.; Pu, B.; Ma, C.; Ba, F.; Xiong, C.; Shi, Y.; Li, J.; Zhang, J.; Liu, Y.
10.1101/2022.03.19.484972 — synthetic biology — Posted on 2022-03-21
1488 Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2
Jana, I. D.; Bhttacharya, P.; Mayilsamy, K.; Banerjee, S.; Bhattacharje, G.; Das, S.; Aditya, S.; Ghosh, A.; McGill, A. R.; Srikrishnan, S.; Das, A. K.; Basak, A.; Mohapatra, S. S.; Chandran, B.; Bhimsaria, D.; Mohapatra, S.; Roy, A.; Mondal, A.
10.1101/2022.03.16.484554 — biochemistry — Posted on 2022-03-21
1489 What is a supercoiling-sensitive gene? Insights from topoisomerase I inhibition in the Gram-negative bacterium Dickeya dadantii
Pineau, M.; Martis B., S.; Forquet, R.; Baude, J.; Villard, C.; Grand, L.; Popowycz, F.; Soulere, L.; Hommais, F.; Nasser, W.; Reverchon, S.; Meyer, S.
10.1101/2021.04.09.439150 — genomics — Posted on 2022-03-21
1490 Ghat: An R package for identifying adaptive polygenic traits
Mahmoud, M.; Tost, M.; Ha, N.-T.; Simianer, H.; Beissinger, T.
10.1101/2020.07.06.189225 — genomics — Posted on 2022-03-21
1491 Complete chloroplast genomes and phylogeny in three Euterpe palms (E. edulis, E. oleraceae and E. precatoria) from different Brazilian biomes
Francisconi, A. F.; dos Santos, L. A. C.; Morales Marroquin, J. A.; van den Berg, C.; Alves-Pereira, A.; Delmondes de Alencar, L.; Picanco-Rodrigues, D.; Zanello, C. A.; Ferreira Costa, M.; Gomes Lopes, M. T.; Veasey, E. A.; Zucchi, M. I.
10.1101/2022.03.21.485093 — evolutionary biology — Posted on 2022-03-21
1493 Surface interaction patches link non-specific binding and phase separation of antibodies
Ausserwöger, H.; Krainer, G.; Welsh, T. J.; Sneideris, T.; Schneider, M. M.; Invernizzi, G.; Herling, T. W.; Lorenzen, N.; Knowles, T. P. J.
10.1101/2022.03.07.483238 — biophysics — Posted on 2022-03-21
1496 State-selective Modulation of Heterotrimeric Gαs Signaling with Macrocyclic Peptides
Dai, S. A.; Hu, Q.; Gao, R.; Peacock, H.; Blythe, E. E.; Zhang, Z.; von Zastrow, M.; Suga, H.; Shokat, K. M.
10.1101/2020.04.25.054080 — biochemistry — Posted on 2022-03-21
1499 Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico
Duncan, E. M.; Nowotarski, S. H.; Guerrero-Hernandez, C.; Ross, E. J.; D'Orazio, J. A.; Clubes de Ciencia Mexico Workshop for Developmental Biology, ; McKinney, S. A.; Guo, L.; McClain, M.; Sanchez Alvarado, A.
10.1101/2020.07.01.183442 — developmental biology — Posted on 2022-03-20
1500 The Heterochromatin protein 1 is a master regulator in RNA splicing precision deficient in ulcerative colitis
Mata -Garrido, J.; Xiang, Y.; Chang-Marchand, Y.; Reisacher, C.; Ageron-ardila, E.; Guerrera, C.; Casafont, I.; Bruneau, A.; Cherbuy, C.; Treton, X.; Dumay, A.; Ogier-Denis, E.; Batsche, E.; Costallat, M.; Revechon, G.; Eriksson, M.; Muchardt, C.; Arbibe, L.
10.1101/2020.12.30.424798 — cell biology — Posted on 2022-03-20
1503 High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
Gooch, H. M.; Bluett, T.; Perumal, M. B.; Vo, H. D.; Fletcher, L. N.; Papacostas, J.; Jeffree, R. L.; Wood, M.; Colditz, M. J.; McMillen, J.; Tsahtsarlis, T.; Amato, D.; Campbell, R.; Gillinder, L.; Williams, S. R.
10.1101/2022.03.16.484669 — neuroscience — Posted on 2022-03-20
1504 Prophylactic efficacy of riluzole against anxiety- and depressive-like behaviors in two rodent stress models
Bansal, Y.; Fee, C.; Misquitta, K.; Codeluppi, S. A.-M.; Sibille, E.; Berman, R.; Coric, V.; Sanacora, G.; Banasr, M.
10.1101/2020.08.07.242057 — pharmacology and toxicology — Posted on 2022-03-20
1505 Combination of the Systemin peptide with the beneficial fungus Trichoderma afroharzianum T22 improves plant defense responses against pests and diseases
Aprile, A. M.; Coppola, M.; Turra, D.; Vitale, S.; Cascone, P.; Diretto, G.; Fiore, A.; Castaldi, V.; Romanelli, A.; Avitalibe, C.; Guerrieri, E.; Woo, S. L.; Rao, R.
10.1101/2022.03.20.485010 — genetics — Posted on 2022-03-20
1507 RAD52 underlies the synthetic-lethal relationship between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta loss.
Starowicz, K.; Ronson, G. E.; Anthony, E.; Clark, L.; Garvin, A. J.; Beggs, A. D.; Whalley, C.; Edmonds, M.; Beesley, J.; Morris, J. R.
10.1101/2022.03.20.485027 — molecular biology — Posted on 2022-03-20
1509 Structural connectivity gradient associated with a dichotomy reveals the topographic organization of the macaque insular cortex
Cao, L.; Du, Z.; Cui, Y.; Zhang, Y.; Lu, Y.; Zhang, B.; Liu, Y.; Hou, X.; Liu, X.; Cheng, L.; Li, K.; Yang, Z.; Fan, L.; Jiang, T.
10.1101/2022.03.18.484254 — neuroscience — Posted on 2022-03-20
1512 Engineering Antioxidant and Oxygen-Releasing Lignin Composites to Accelerate Wound Healing
Balaji, S.; Short, W. D.; Padon, B. W.; Prajapati, T. J.; Farouk, F.; Belgodere, J. A.; Jimenez, S. E.; Deoli, N. T.; Guidry, A. C.; Green, J. C.; Kaul, A.; Son, D.; Jung, O. S.; Astete, C. E.; Kim, M.; Jung, J. P.
10.1101/2022.03.18.484913 — bioengineering — Posted on 2022-03-20
1513 Near telomere-to-telomere nuclear phased chromosomes of the dikaryotic wheat fungus Rhizoctonia cerealis
Zeng, Q.; Cao, W.; Li, W.; Wu, J.; Figueroa, M.; Liu, H.; Qin, G.; Wang, Q.; Yang, L.; Zhou, Y.; Yu, Y.; Huang, L.; Liu, S.; Luo, Y.; Mu, Z.; Li, X.; Liu, J.; Wang, X.; Wang, C.; Yuan, F.; Chen, H.; Xu, H.; Dodds, P.; Han, D.; Kang, Z.
10.1101/2022.03.18.484966 — genomics — Posted on 2022-03-20
1518 Environmental and genetic disease modifiers of haploinsuffciency of A20
Zammit, N. N.; Gray, P.; Siggs, O. M.; Yap, J. Y.; Russell, A.; Cultrone, D.; Warren, J.; Walters, S. N.; Brink, R. T.; Zahra, D.; Burnett, D. L.; Gayevskiy, V.; Minoche, A. E.; Ziegler, J. B.; Craig, M. E.; Wong, M.; Benitez-Aguirre, P.; Teo, J.; Cowley, M. J.; Dinger, M. E.; Tangye, S. G.; Burk, C.; Phan, T. G.; Goodnow, C. J.; Grey, S. T.
10.1101/2022.03.19.485004 — immunology — Posted on 2022-03-20
1522 In vivo low-intensity magnetic pulses durably alter neocortical neuron excitability and spontaneous activity.
Boyer, M.; Baudin, P.; Stengel, C.; Valero-Cabre, A.; Lohof, A. M.; Charpier, S.; Sherrard, R. M.; Mahon, S.
10.1101/2022.03.18.484911 — neuroscience — Posted on 2022-03-20
1526 TATTOO-seq delineates spatial and cell type-specific regulatory programs during limb patterning
Bastide, S.; Chomsky, E.; Saudemont, B.; Loe-Mie, Y.; Schmutz, S.; Novault, S.; Marlow, H.; Tanay, A.; Spitz, F.
10.1101/2022.03.20.482385 — systems biology — Posted on 2022-03-20
1527 A Tailored Approach To Study Legionella Infection Using Lattice Light Sheet Microscope (LLSM)
Yi, X.; Miao, H.; Lo, J. K.-Y.; Elsheikh, M.; Lee, T.-H.; Jiang, C.; Segelke, B. W.; Overton, K. W.; Bremer, P.-T.; Laurence, T. A.
10.1101/2022.03.20.485032 — bioengineering — Posted on 2022-03-20
1528 LINE-1 retrotransposon activation intrinsic to interneuron development
Bodea, G. O.; Ferreiro, M. E.; Sanchez-Luque, F. J.; Botto, J. M.; Rasmussen, J.; Rahman, M. A.; Fenlon, L. R.; Gubert, C.; Gerdes, P.; Bodea, L.-G.; Ajjikuttira, P.; Kozulin, P.; Billon, V.; Morell, S.; Kempen, M.-J. H.; Love, C. J.; Palmer, L. M.; Ewing, A. D.; Jhaveri, D. J.; Richardson, S. R.; Hannan, A. J.; Faulkner, G. J.
10.1101/2022.03.20.485017 — genomics — Posted on 2022-03-20
1531 Lysosomal vesiculophagy terminates STING signalling
Kuchitsu, Y.; Mukai, K.; Takaada, Y.; Shinojima, A.; Hamano, S.; Uematsu, R.; Ogawa, E.; Suzuki, T.; Dohmae, N.; Uemura, T.; Arai, H.; Waguri, S.; Taguchi, T.
10.1101/2022.03.20.485012 — cell biology — Posted on 2022-03-20
1532 STING controls T cell memory fitness during infection through T cell intrinsic and IDO dependent mechanisms
Teixeiro, E.; Quaney, M. J.; Newth, R. J.; Knudson, K. M.; Saxena, V.; Pritzl, C. J.; Rae, C. S.; Lauer, P.; Daniels, M. A.
10.1101/2022.03.19.484992 — immunology — Posted on 2022-03-20
1533 Cannabinoids regulate an insula circuit controlling water intake
Zhao, Z.; Covelo, A.; Mitra, A.; Varilh, M.; Wu, Y.; Jacky, D.; Cannich, A.; Bellocchio, L.; Marsicano, G.; Beyeler, A.
10.1101/2022.03.18.484736 — neuroscience — Posted on 2022-03-20
1534 A dataset of 5 million city trees: species clustering and climate effects in urban forests
McCoy, D.; Goulet-Scott, B.; Meng, W.; Atahan, B. F.; Kiros, H.; Nishino, M.; Kartesz, J.
10.1101/2022.03.18.484862 — ecology — Posted on 2022-03-20
1535 Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy
Karim, M.; Saul, S.; Ghita, L.; Sahoo, M. K.; Ye, C.; Bhalla, N.; Jin, J.; Park, J.-G.; Martinez-Gualda, B.; Patrick East, M.; L. Johnson, G.; Pinsky, B. A.; Martinez-Sobrido, L.; Asquith, C. R. M.; Narayanan, A.; De Jonghe, S.; Einav, S.
10.1101/2022.03.18.484178 — microbiology — Posted on 2022-03-20
1536 Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells
Du, L.; Bouzidi, M. S.; Gala, A.; Deiter, F.; Billaud, J.-N.; Yeung, S.; Dabral, P.; Jin, J.; Simmons, G.; Dossani, Z.; Niki, T.; Ndhlovu, L.; Greenland, J.; Pillai, S. K.
10.1101/2022.03.18.484956 — microbiology — Posted on 2022-03-20
1538 Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine
Arunachalam, P. S.; Feng, Y.; Ashraf, U.; Hu, M.; Edara, V. V.; Zarnitsyna, V. I.; Aye, P. P.; Golden, N.; Green, K. W. M.; Threeton, B. M.; Maness, N. J.; Beddingfield, B. J.; Bohm, R. P.; Dufour, J.; Russell-Lodrigue, K.; Miranda, M. C.; Walls, A. C.; Rogers, K.; Shirreff, L.; Ferrell, D. E.; Adhikary, N. R. D.; Fontenot, J.; Grifoni, A.; Sette, A.; O Hagan, D. T.; Most, R. V. D.; Rappuoli, R.; Villinger, F. J.; Kleanthous, H.; Rappaport, J.; Suthar, M. S.; Veesler, D.; Wang, T. T.; King, N. P.; Pulendran, B.
10.1101/2022.03.18.484950 — immunology — Posted on 2022-03-20
1541 Enteroendocrine cell lineages that differentially control feeding and gut motility
Hayashi, M.; Kaye, J. A.; Douglas, E. R.; Joshi, N. R.; Gribble, F. M.; Reimann, F.; Liberles, S.
10.1101/2022.03.18.484842 — neuroscience — Posted on 2022-03-20
1544 Altered patterning of interneuron progenitors in Down syndrome
Giffin-Rao, Y.; Sheng, J.; Strand, B.; Xu, K.; Huang, L.; Medo, M.; Risgaard, K. A.; Dantinne, S.; Mohan, S.; Keshan, A.; Daley, R. A.; Levesque, B.; Amundson, L.; Reese, R.; Sousa, A.; Tao, Y.; Wang, D.; Zhang, S.-C.; Bhattacharyya, A.
10.1101/2020.02.18.951756 — developmental biology — Posted on 2022-03-20
1545 Functional characterization of the thrombospondin-related paralogous proteins rhoptry discharge factor 1 and 2 unveils phenotypic plasticity in Toxoplasma gondii rhoptry exocytosis
Possenti, A.; Di Cristina, M.; Nicastro, C.; Lunghi, M.; Messina, V.; Piro, F.; Tramontana, L.; Cherchi, S.; Falchi, M.; Bertuccini, L.; Spano, F.
10.1101/2022.03.02.482699 — microbiology — Posted on 2022-03-20
1546 Accelerated Predictive Healthcare Analytics with Pumas, A High Performance Pharmaceutical Modeling and Simulation Platform
Rackauckas, C. V.; Ma, Y.; Noack, A.; Dixit, V.; Mogensen, P.; Elrod, C.; Tarek, M.; Byrne, S.; Maddhashiya, S.; Calderon, J. B. S.; Hatherly, M.; Nyberg, J.; Gobburu, J.; Ivaturi, V.
10.1101/2020.11.28.402297 — pharmacology and toxicology — Posted on 2022-03-20
1547 KAT5 activity regulates G0-like states in human gliomas
Mihalas, A.; Arora, S.; O'Connor, S.; Feldman, H.; Bassett, J.; Mitchell, K.; Jin, K.; Hoellerbauer, P.; Delegard, J.; Ling, M.; Jenkins, W.; Kufeld, M.; Corrin, P.; Carter, L.; Aronow, B. J.; Plaisier, C. J.; Patel, A.; PADDISON, P.
10.1101/2022.03.17.484768 — cancer biology — Posted on 2022-03-20
1549 The DC1 domain protein BINUCLEATE POLLEN is required for pollen development in Arabidopsis
Arias, L. A.; D'Ippolito, S.; Frik, J.; Amigo, N.; Casalongue, C. A.; Pagnussat, G. C.; Fiol, D. F.
10.1101/2022.03.17.484815 — plant biology — Posted on 2022-03-20
1551 Using a combination of CRISPR/Cas9, behavioural experiments and functional analysis to characterise taste receptors in honeybees
Degirmenci, L.; Roge Ferreira, F. L.; Vukosavljevic, A.; Heindl, C.; Keller, A.; Geiger, D.; Scheiner, R.
10.1101/2022.03.17.484777 — physiology — Posted on 2022-03-20
1552 Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets
Zhao, J.; Wang, G.; Ming, J.; Lin, Z.; Wang, Y.; The Tabula Microcebus Consortium, ; Wu, A. R.; Yang, C.
10.1101/2021.11.16.468892 — bioinformatics — Posted on 2022-03-20
1553 Evidence that conserved essential genes are enriched for pro-longevity factors
Oz, N.; Vayndorf, E.; Tsuchiya, M.; McLean, S.; Turcios-Hernandez, L.; Pitt, J. N.; Blue, B. W.; Muir, M.; Kiflezghi, M. G.; Tyshkovskiy, A.; Mendenhall, A.; Kaeberlein, M.; Kaya, A.
10.1101/2022.03.18.484929 — cell biology — Posted on 2022-03-20
1555 Genetic Analysis Suggests a Surface of PAT-4 (ILK) that Interacts with UNC-112 (kindlin)
Benian, G.; Qadota, H.; McPherson, A.; Corbitt, R.; Dackowski, E. K.; Matsunaga, Y.; Oberhauser, A. F.
10.1101/2022.03.18.484907 — genetics — Posted on 2022-03-20
1556 Persistent postnatal migration of interneurons into the human entorhinal cortex
Nascimento, M. A.; Biagiotti, S.; Herranz-Perez, V.; Bueno, R.; Ye, C. J.; Abel, T.; Moll, J. S. R.; Garcia-Verdugo, J. M.; Huang, E. J.; Alvarez-Buylla, A.; Sorrells, S. F.
10.1101/2022.03.19.484996 — neuroscience — Posted on 2022-03-20
1559 ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis
Jourdon, A.; Wu, F.; Mariani, J.; Capauto, D.; Norton, S.; Tomasini, L.; Amiri, A.; Suvakov, M.; Schreiner, J.; Jang, Y.; Nguyen, C. K.; Cummings, E. M.; Han, G.; Powell, K.; Szekely, A.; McPartland, J. C.; Pelphrey, K.; Chawarska, K.; Ventola, P.; Abyzov, A.; Vaccarino, F. M.
10.1101/2022.03.19.484988 — neuroscience — Posted on 2022-03-20
1560 Multifaceted Atlases of the Human Brain in its Infancy
Ahmad, S.; Wu, Y.; Wu, Z.; Thung, K.-H.; Lin, W.; Li, G.; Wang, L.; Yap, P.-T.
10.1101/2022.03.19.484985 — neuroscience — Posted on 2022-03-20
1561 Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes
Janaszkiewicz, A.; Toth, A.; Faucher, Q.; Martin, M.; Chantemargue, B.; Barin-Le Guellec, C.; Marquet, P.; Di Meo, F.
10.1101/2022.01.10.475390 — pharmacology and toxicology — Posted on 2022-03-20
1563 Sequence-structure-function relationships in the microbial protein universe
Koehler Leman, J.; Szczerbiak, P.; Renfrew, P. D.; Gligorijevic, V.; Berenberg, D.; Vatanen, T.; Taylor, B. C.; Chandler, C.; Janssen, S.; Carriero, N.; Fisk, I.; Xavier, R. J.; Knight, R.; Bonneau, R.; Kosciolek, T.
10.1101/2022.03.18.484903 — bioinformatics — Posted on 2022-03-20
1565 High resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences
Bodde, M.; Makunin, A.; Ayala, D.; Bouafou, L.; Diabate, A.; Ekpo, U. F.; Kientega, M.; Le Goff, G.; Makanga, B. K.; Ngangue, M. F.; Omitola, O. O.; Rahola, N.; Tripet, F.; Durbin, R.; Lawniczak, M. K. N.
10.1101/2022.03.18.484650 — evolutionary biology — Posted on 2022-03-20
1566 Drivers of nematode diversity in forest soils across climatic zones
Shao, Y.; Wang, Z.; Liu, T.; Kardol, P.; Ma, C.; Hu, Y.; Cui, Y.; Zhao, C.; Zhang, W.; Guo, D.; Fu, S.
10.1101/2022.03.18.484848 — ecology — Posted on 2022-03-20
1569 Chloroplast protein import determines plant proteostasis and retrograde signaling
Llamas, E.; Koyuncu, S.; Lee, H. J.; Gutierrez-Garcia, R.; Dunken, N.; Charura, N.; Torres-Montilla, S.; Schlimgen, E.; Pulido, P.; Rodriguez-Concepcion, M.; Zuccaro, A.; Vilchez, D.
10.1101/2022.03.19.484971 — plant biology — Posted on 2022-03-20
1570 Zhx2 is a candidate gene underlying oxymorphone metabolite brain concentration associated with state-dependent oxycodone reward
Beierle, J. A.; Yao, E. J.; Goldstein, S. I.; Lynch, W. B.; Scotellaro, J. L.; Sena, K. D.; Wong, A. L.; Linnertz, C. A.; Averin, O.; Moody, D. E.; Reilly, C. A.; Peltz, G. A.; Emili, A.; Ferris, M. T.; Bryant, C. D.
10.1101/2022.03.18.484877 — pharmacology and toxicology — Posted on 2022-03-20
1575 Structural and functional insight into the plant unique multimodular triphosphosphate tunnel metalloenzymes of Arabidopsis thaliana
Pesquera, M.; Martinez, J.; Wang, K.; Hofmann, M.; Loubery, S.; Steensma, P.; Hothorn, M.; Fitzpatrick, T. B.
10.1101/2022.03.18.484887 — plant biology — Posted on 2022-03-19
1576 Ovule siRNAs methylate protein-coding genes in trans
Burgess, D.; Chow, H. T.; Grover, J. W.; Freeling, M.; Mosher, R. A.
10.1101/2021.06.10.447945 — plant biology — Posted on 2022-03-19
1581 Mitochondrial Matrix Protease ClpP Agonists inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Greer, Y. E.; Hernandez, L.; Fennell, E. M. J.; Voeller, D.; Chari, R.; Gilbert, S. F.; Tang, B.; Hafner, M.; Annunziata, C.; Iwanowicz, E.; Graves, L. M.; Lipkowitz, S.
10.1101/2022.03.18.484947 — cancer biology — Posted on 2022-03-19
1582 Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment
Hirz, T.; Mei, S.; Sarkar, H.; Kfoury, Y.; Wu, S.; Verhoeven, B. M.; Subtelny, A. O.; Zlatev, D. V.; Wszolek, M. W.; Salari, K.; Murray, E.; Chen, F.; Macosko, E. Z.; Wu, C.-L.; Scadden, D. T.; Dahl, D. M.; Baryawno, N.; Saylor, P. J.; Kharchenko, P. V.; Sykes, D. B.
10.1101/2022.03.18.484781 — cancer biology — Posted on 2022-03-19
1584 Development of ONT-cappable-seq to unravel the transcriptional landscape of Pseudomonas phages
Putzeys, L.; Boon, M.; Lammens, E.-M.; Kuznedelov, K.; Severinov, K.; Lavigne, R.
10.1101/2022.03.18.484859 — genomics — Posted on 2022-03-19
1586 Low-Toxin Clostridioides difficile RT027 Strains Exhibit Robust Virulence
Anwar, F.; Roxas, B. A. P.; Shehab, K. W.; Ampel, N.; Viswanathan, V. K.; Vedantam, G.
10.1101/2022.03.18.484943 — microbiology — Posted on 2022-03-19
1587 Microglial amyloid beta clearance is driven by PIEZO1 channels
Konttinen, H.; Sitnikova, V.; Ishchenko, Y.; Shakirzyanova, A.; Giudice, L.; Ugidos, I. F.; Gomez Budia, M.; Korvenlaita, N.; Ohtonen, S.; Belaya, I.; Fazaludeen, F.; Mikhailov, N.; Gotkiewicz, M.; Ketola, K.; Lehtonen, S.; Koistinaho, J.; Kanninen, K.; Hernandez, D.; Pebay, A.; Giugno, R.; Korhonen, P.; Giniatullin, R.; Malm, T.
10.1101/2022.03.18.484831 — neuroscience — Posted on 2022-03-19
1589 Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs
Liu, X.; Moscvin, M.; Oh, S.; Chen, T.; Choi, W.; Evans, B.; Rowell, S. M.; Nadeem, O.; Mo, C. C.; Sperling, A. S.; Anderson, K. C.; Yaqoob, Z.; Bianchi, G.; Sung, Y.
10.1101/2022.03.18.484926 — systems biology — Posted on 2022-03-19
1590 Configurable Compartmentation Enables In vitro Reconstitution of Sustained Synthetic Biology Systems
Li, L.; Zhang, R.; Tian, X.; Li, T.; Pu, B.; Ma, C.; Ba, F.; Xiong, C.; Shi, Y.; Li, J.; Zhang, J.; Liu, Y.
10.1101/2022.03.19.484972 — synthetic biology — Posted on 2022-03-19
1591 Proteomic identification of the interactome of stalled ribosome nascent chain complexes translating the thylakoid membrane protein D1
Stolle, D. S.; Treimer, P.; Lambertz, J.; Osterhoff, L.; Bischoff, A.; Dunschede, B.; Rodiger, A.; Herrmann, C.; Baginsky, S.; Nowaczyk, M. M.; Schunemann, D.
10.1101/2022.03.18.484870 — plant biology — Posted on 2022-03-19
1592 Vimentin intermediate filament assembly is a reversible process
Tran, Q. D.; Sorichetti, V.; Pehau-Arnaudet, G.; Lenz, M.; Leduc, C.
10.1101/2022.03.19.484978 — biophysics — Posted on 2022-03-19
1595 Wochenende - modular and flexible alignment-based shotgun metagenome analysis
Rosenboom, I.; Friedrich, F. C.; Poertner, S.; Pust, M.-M.; Wehrbein, T.; Rosenhahn, B.; Wiehlmann, L.; Chhatwal, P.; Tuemmler, B.; Davenport, C. F.
10.1101/2022.03.18.484377 — bioinformatics — Posted on 2022-03-19
1596 One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant
Buck, K. M.; Roberts, D. S.; Aballo, T. J.; Inman, D. R.; Jin, S.; Ponik, S. M.; Brown, K. A.; Ge, Y.
10.1101/2022.03.18.484933 — biochemistry — Posted on 2022-03-19
1601 Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses
Chang, C.-F.; Gunawan, A. L.; Zushin, P.-J. H.; Timblin, G. A.; Bertholet, A. M.; Wang, B.; Saijo, K.; Kirichok, Y.; Stahl, A.
10.1101/2022.03.18.484957 — cell biology — Posted on 2022-03-19
1609 Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies
Scheepers, C.; Kgagudi, P.; Mzindle, N.; Gray, E. S.; Moyo-Gwete, T.; Lambson, B. E.; Oosthuysen, B.; Mabvakure, B.; Garrett, N. J.; Karim, S. S. A.; Morris, L.; Moore, P. L.
10.1101/2022.03.18.484856 — immunology — Posted on 2022-03-19
1610 Alpha-1 Antitrypsin Limits Neutrophil Extracellular Trap Disruption of Airway Epithelial Barrier Function
Hudock, K. M.; Collins, M. S.; Imbrogno, M. A.; Brewington, J. J.; Ziady, A.; Zhang, N.; Snowball, J. M.; Xu, Y.; Carey, B.; Horio, Y.; O'Grady, S.; Kopras, E.; Meeker, J.; Morgan, H.; Ostmann, A.; Skala, E.; Seifert, M.; Gollomp, K.; Mangalmurti, N.; Trapnell, B.; Clancy, J. P.
10.1101/2022.03.18.484920 — immunology — Posted on 2022-03-19
1611 Strategies to Identify and Edit Improvements in Synthetic Genome Segments Episomally.
Rudolph, A. I.; Nyerges, A.; Chiappino-Pepe, A.; Landon, M.; Baas-Thomas, M.; Church, G.
10.1101/2022.03.18.484905 — synthetic biology — Posted on 2022-03-19
1613 Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography
Hu, S.; Liu, S.; Yu, B.; Poddar, M.; Singh, S.; Cao, C.; McGaughey, J.; Bell, A.; Blazer, L. L.; Adams, J.; Sidhu, S.; Angers, S.; Monga, S. P.
10.1101/2022.03.18.484868 — pathology — Posted on 2022-03-19
1614 Ratiometric Sensing of Redox Environments Inside Individual Carboxysomes Trapped in Solution
Carpenter, W. B.; Lavania, A. A.; Borden, J. S.; Oltrogge, L. M.; Perez, D. D.; Dahlberg, P. D.; Savage, D. F.; Moerner, W. E.
10.1101/2022.03.17.484789 — biophysics — Posted on 2022-03-19
1616 Studies of a siderophore-producing cyclization domain: A refined proposal of substrate binding
Gnann, A. D.; Xia, Y.; Soule, J.; Barthelemy, C.; Mawani, J. S.; Nzikoba Musoke, S.; Castellano, B. M.; Brignole, E. J.; Frueh, D.; Dowling, D. P.
10.1101/2022.03.18.483834 — biochemistry — Posted on 2022-03-19
1619 A role of Lck annular lipids in the steady upkeep of active Lck in T cells
Porciello, N.; Cipria, D.; Masi, G.; Lanz, A.-L.; Milanetti, E.; Grottesi, A.; Howie, D.; Cobbold, S. P.; Schermelleh, L.; D'Abramo, M.; He, H.-T.; Destainville, N.; Acuto, O.; Nika, K.
10.1101/2022.03.18.484902 — cell biology — Posted on 2022-03-19
1620 Transcriptional analysis identifies overlapping and tissue-distinct profiles between Kaposi sarcoma tumors of the skin and gastrointestinal tract
Ramaswami, R.; Tagawa, T.; Mahesh, G.; Serquina, A.; Koparde, V.; Lurain, K.; Dremel, S.; Li, X.; Mungale, A.; Beran, A.; Weaver Ohler, Z.; Bassel, L.; Warner, A.; Mangusan, R.; Widell, A.; Ekwede, I.; Krug, L. T.; Uldrick, T. S.; Yarchoan, R.; Ziegelbauer, J. M.
10.1101/2022.03.18.484923 — microbiology — Posted on 2022-03-19
1622 Antimicrobial peptide secretion protects endosymbionts from bacteriome autoimmunity in insects
Galvao Ferrarini, M.; Dell'Aglio, E.; Vallier, A.; Balmand, S.; Vincent-Monegat, C.; Hughes, S.; Gillet, B.; Parisot, N.; Zaidman-Remy, A.; Vieira, C.; Heddi, A.; Rebollo, R.
10.1101/2022.03.18.484386 — immunology — Posted on 2022-03-19
1624 Maternal separation induces autism spectrum disorder in young rhesus monkeys
Ren, X.-F.; Wu, S.-H.; Zhou, H.; Lv, L.-B.; Qiu, Z.-L.; Feng, X.-L.; Hu, X.-T.
10.1101/2022.03.17.484827 — neuroscience — Posted on 2022-03-19
1625 Behavioral and dopaminergic signatures of resilience
Willmore, L.; Cameron, C.; Yang, J.; Witten, I.; Falkner, A.
10.1101/2022.03.18.484885 — neuroscience — Posted on 2022-03-19
1627 Distribution and frequency of salivary gland tumours: an international multicenter study
Alsanie, I.; Rajab, S.; Cottom, H.; Adegun, O.; Agarwal, R.; Jay, A.; Graham, L.; James, J.; Barrett, A. W.; van Heerden, W.; de Vito, M.; Canesso, A.; Adisa, A. O.; Akinshipo, A.-W. O.; Ajayi, O. F.; Nwoga, M. C.; Okwuosa, C. U.; Omitola, O. G.; Orikpete, E. V.; Soluk-Tekkesin, M.; Bello, I.; Qannam, A.; Gonzalez, W.; de Oliveira, M. E. P.; Vargas, P. A.; Santos-Silva, A. R.; Toh, E.-W.; Khurram, S. A.
10.1101/2022.03.17.484728 — pathology — Posted on 2022-03-19
1629 Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish
Travnickova, J.; Muise, S.; Wojciechowska, S.; Brombin, A.; Zeng, Z.; Wyatt, C.; Patton, E. E.
10.1101/2022.03.17.484741 — cancer biology — Posted on 2022-03-19
1630 Evidence-based calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for clinical use of PP3/BP4 criteria
Pejaver, V.; Byrne, A. B.; Feng, B.-J.; Pagel, K. A.; Mooney, S. D.; Karchin, R.; O'Donnell-Luria, A.; Harrison, S. M.; Tavtigian, S. V.; Greenblatt, M. S.; Biesecker, L. G.; Radivojac, P.; Brenner, S. E.; ClinGen Sequence Variant Interpretation Working Group,
10.1101/2022.03.17.484479 — bioinformatics — Posted on 2022-03-19
1631 Symbolic quantitative cognition in wild zebrafish (Danio rerio)
Abdul Majeed, N.; Singh, D.; Baiju Gopal, A.; Battiwala, T.; Kulshreshtha, N.; Mishra, R.; Sabharwal, S.; Behera, M.; Sahu, M.; Menon, A.; Bungsut, L.; Walia, A.; Saraf, R.; Mathew, S.; Shah, A.; Kochhar, S.; Salar, N.; Thakuri, S.; Sharma, Y.; Rampuria, N.; Bhattacharjee, A.; Wagh, N.; Bulhan, I.; Hegde, S.; Singh, G.; Rajaraman, B. K.
10.1101/2022.03.17.484678 — animal behavior and cognition — Posted on 2022-03-19
1638 Novel diversity panel facilitates genomic dissection of lodging in tef (Eragrostis tef)
Ben-Zeev, S.; Hellwig, T.; Demeile, M.; Barak, V.; Vorobyova, S.; Hubner, S.; Saranga, Y.
10.1101/2022.03.17.484745 — plant biology — Posted on 2022-03-19
1639 Temporal integration of rod signals in luminance and chromatic pathways
Cormenzana Mendez, I.; Martin, A.; O'Donell, B.; Cao, D.; Barrionuevo, P. A.
10.1101/2022.03.17.484829 — physiology — Posted on 2022-03-19
1640 Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy
Yoshioka, N.; Kurose, M.; Yano, M.; Tran, D. M.; Okuda, S.; Mori-Ochiai, Y.; Horie, M.; Nagai, T.; Nishino, I.; Shibata, S.; Takebayashi, H.
10.1101/2022.03.17.484743 — pathology — Posted on 2022-03-19
1641 SPDEF promotes the classical subtype of pancreatic ductal adenocarcinoma.
Tonelli, C.; Yordanov, G. N.; Hao, Y.; Deschenes, A.; Klingbeil, O.; Ting, H.-C.; Brosnan, E.; Doshi, A.; Park, Y.; Vakoc, C. R.; Preall, J.; Tuveson, D.
10.1101/2022.03.18.484951 — cancer biology — Posted on 2022-03-19
1642 Modeling of Aryl Hydrocarbon Receptor Pathway Intrinsic Immunometabolic Role using Glioblastoma Stem Cells and Patient-Derived Organoids
Watanabe, F.; Hollingsworth, E. W.; Banasavadi-Siddegowda, Y.; Bartley, J. M.; Sizemore, S. T.; Yu, L.; Pietrzak, M.; Schiapparelli, P.; Puduvalli, V.; Kaur, B.; Quinones-Hinojosa, A.; Imitola, J.
10.1101/2022.03.17.484756 — cancer biology — Posted on 2022-03-19
1643 Phenotype to genotype mapping using supervised and unsupervised learning
Pastore, V. P.; Oke, A.; Capponi, S.; Elnatan, D.; Fung, J.; Bianco, S.
10.1101/2022.03.17.484826 — bioinformatics — Posted on 2022-03-19
1650 A novel PLS1 c.981+1G>A variant causes autosomal-dominant hereditary hearing loss in a family via up-regulation of the PI3K-Akt signaling pathway
Xu, L.; Wang, X.; Li, J.; Chen, L.; Wang, H.; Xu, S.; Zhang, Y.; Li, W.; Yao, P.; Tan, M.; Zhou, S.; Chen, M.; Pan, Y.; Chen, X.; Chen, X.; Liu, Y.; Lin, N.; Huang, H.; Cao, H.
10.1101/2022.03.17.484618 — genetics — Posted on 2022-03-19
1651 Towards understanding diversity, endemicity and global change vulnerability of soil fungi
Tedersoo, L.; Mikryukov, V.; Zizka, A.; Bahram, M.; Hagh-Doust, N.; Anslan, S.; Prylutskyi, O.; Delgado-Baquerizo, M.; Maestre, F. T.; Parn, J.; opik, M.; Moora, M.; Zobel, M.; Espenberg, M.; Mander, u.; Khalid, A. N.; Corrales, A.; Agan, A.; Vasco-Palacios, A.-M.; Saitta, A.; Rinaldi, A. C.; Verbeken, A.; Sulistyo, B. P.; Tamgnoue, B.; Furneaux, B.; Ritter, C. D.; Nyamukondiwa, C.; Sharp, C.; Marin, C.; Gohar, D.; Klavina, D.; Sharmah, D.; Dai, D.; Nouhra, E.; Biersma, E. M.; Rahn, E.; Cameron, E. K.; De Crop, E.; Otsing, E.; Davydov, E. A.; Albornoz, F. E.; Brearley, F. Q.; Buegger, F.; Zahn
10.1101/2022.03.17.484796 — ecology — Posted on 2022-03-19
1652 Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells
Cecon, E.; Oishi, A.; Luka, M.; Ndiaye-Lobry, D.; Francois, A.; Panayi, F.; Dam, J.; Machado, P.; Jockers, R.
10.1101/2022.03.18.484918 — cell biology — Posted on 2022-03-19
1653 Condensin positioning at telomeres by Taz1 promotes telomere disjunction in anaphase
Colin, L.; Reyes, C.; Berthezene, J.; Maestroni, L.; Modolo, L.; Toselli, E.; Chanard, N.; Schaak, S.; Cuvier, O.; Gachet, Y.; Coulon, S.; Bernard, P.; Tournier, S.
10.1101/2022.03.18.484892 — cell biology — Posted on 2022-03-19
1654 Beneficial effects of prolonged 2-phenylethyl alcohol inhalation on chronic distress-induced anxio-depressive-like phenotype in female mice
RAMADAN, B.; CABEZA, L.; CRAMOISY, S.; HOUDAYER, C.; ANDRIEU, P.; MILLOT (decesased), J.-L.; HAFFEN, E.; RISOLD, P.-Y.; PETERSCHMITT, Y. N.
10.1101/2022.03.17.484716 — neuroscience — Posted on 2022-03-19
1663 Altered PVN-to-CA2 hippocampal oxytocin pathway and reduced number of oxytocin-receptor expressing astrocytes in heart failure rats
Althammer, F.; Roy, R. K.; Lefevre, A.; Najjar, R.; Schoenig, K.; Bartsch, D.; Eliava, M.; Feresin, R.; Hammock, E.; Murphy, A. Z.; Charlet, A.; Grinevich, V.; Stern, J. E.
10.1101/2022.03.17.484603 — neuroscience — Posted on 2022-03-19
1667 Single-nucleotide substitution determines pollen production in Japanese cedar
Kakui, H.; Ujino-Ihara, T.; Hasegawa, Y.; Tsurisaki, E.; Futamura, N.; Iwai, J.; Higuchi, Y.; Fujino, T.; Suzuki, Y.; Kasahara, M.; Yamaguchi, K.; Shigenobu, S.; Otani, M.; Nakano, M.; Ueno, S.; Moriguchi, Y.
10.1101/2022.03.17.484665 — plant biology — Posted on 2022-03-19
1668 Toxicological Analysis of Poly-Lactide Co-Glycolide Microparticles, Chitosan Nanoparticles and Poly(Anhydride) Nanoparticles in Vero Cell
HAZARIKA, D.; BORAH, D. P.; BORUAH, J. S.; TAPADAR, Y. B.; SULTANA, A.; TAMULY, S.; NATH, R.; CHOWDHURY, D.; DUTTA, B.; BORAH, P.; KALITA, D. J.
10.1101/2022.03.17.484425 — pharmacology and toxicology — Posted on 2022-03-19
1670 KAT5 activity regulates G0-like states in human gliomas
Mihalas, A.; Arora, S.; O'Connor, S.; Feldman, H.; Bassett, J.; Mitchell, K.; Jin, K.; Hoellerbauer, P.; Ling, M.; Jenkins, W.; Kufeld, M.; Corrin, P.; Carter, L.; Aronow, B. J.; Plaisier, C. J.; Patel, A.; PADDISON, P.
10.1101/2022.03.17.484768 — cancer biology — Posted on 2022-03-19
1671 Proteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis
Krasny, L.; Wilding, C.; Perkins, E.; Arthur, A.; Guljar, N.; Jenks, A.; Fisher, C.; Judson, I.; Thway, K.; Jones, R.; Huang, P.
10.1101/2022.03.17.484830 — cancer biology — Posted on 2022-03-19
1672 MINSTED nanoscopy enters the Angstrom localization range
Weber, M.; von der Emde, H.; Leutenegger, M.; Gunkel, P.; Cordes, V. C.; Sambandan, S.; Khan, T. A.; Keller-Findeisen, J.; Hell, S. W.
10.1101/2022.03.18.484906 — biophysics — Posted on 2022-03-19
1673 Complementing machine learning-based structure predictions with native mass spectrometry
Allison, T. M.; Degiacomi, M. T.; Marklund, E. G.; Jovine, L.; Elofsson, A.; Benesch, J. L.; Landreh, M.
10.1101/2022.03.17.484776 — biophysics — Posted on 2022-03-19
1675 Towards reliable quantification of cell state velocities
Marot-Lassauzaie, V.; Bouman, B. J.; Donaghy, F. D.; Haghverdi, L.
10.1101/2022.03.17.484754 — bioinformatics — Posted on 2022-03-19
1678 EXONIZATION BY THE EMERGENCE OF A CLEAVAGE-POLYADENYLATION SITE
Mereau, A.; Lerivray, H.; Viet, J.; Hardy, S.; Paillard, L.; Audic, Y.
10.1101/2022.03.17.484714 — evolutionary biology — Posted on 2022-03-19
1682 The rate of information transmission through the MAPK/ERKsignaling pathway stimulated in a pulsatile manner
Nalecz-Jawecki, P.; Gagliardi, P. A.; Kochanczyk, M.; Dessauges, C.; Pertz, O.; Lipniacki, T.
10.1101/2022.03.17.484713 — systems biology — Posted on 2022-03-19
1683 Geology and discovery record of the Trinil Pithecanthropus erectus site, Java
Huffman, O. F.; Berkhout, A. W. J.; Albers, P. C. H.; de Vos, J.; Aziz, F.
10.1101/2022.03.15.484451 — paleontology — Posted on 2022-03-19
1687 A novel, NADH-dependent acrylate reductase in Vibrio harveyi
Bertsova, Y. V.; Serebryakova, M.; Baykov, A. A.; Bogachev, A. V.
10.1101/2022.01.20.477176 — biochemistry — Posted on 2022-03-19
1688 ODGI: understanding pangenome graphs
Guarracino, A.; Heumos, S.; Nahnsen, S.; Prins, P.; Garrison, E.
10.1101/2021.11.10.467921 — genomics — Posted on 2022-03-19
1691 The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton
Alsina, F. C.; Lupan, B. M.; Lin, L. J.; Musso, C. M.; Mosti, F.; Newman, C. R.; Wood, L. M.; Agostino, M.; Moore, J. K.; Silver, D. L.
10.1101/2022.03.18.484888 — neuroscience — Posted on 2022-03-19
1693 Glial control of sphingolipid levels sculpts diurnal remodeling of sleep circuitry
Vaughen, J.; Theisen, E.; Rivas-Serna, I. M.; Berger, A. B.; Anreiter, I.; Mazurak, V.; Reimer, R.; Clandinin, T.; Clandinin, T.
10.1101/2022.03.18.484007 — neuroscience — Posted on 2022-03-19
1694 START domain mediates Arabidopsis GLABRA2 transcription factor dimerization and turnover independently of homeodomain DNA binding
Mukherjee, T.; Subedi, B.; Khosla, A.; Begler, E. M.; Stephens, P. M.; Warner, A. L.; Lerma-Reyes, R.; Thompson, K. A.; Gunewardena, S.; Schrick, K.
10.1101/2021.11.23.469727 — plant biology — Posted on 2022-03-19
1695 Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortex
Uzquiano, A.; Kedaigle, A. J.; Pigoni, M.; Paulsen, B.; Adiconis, X.; Kim, K.; Faits, T.; Nagaraja, S.; Anton-Bolanos, N.; Gerhardinger, C.; Tucewicz, A.; Murray, E.; Buenrostro, J.; Chen, F.; Velasco, S.; Regev, A.; Levin, J. Z.; Arlotta, P.
10.1101/2022.03.17.484798 — neuroscience — Posted on 2022-03-19
1700 COVID-19 patients have increased levels of membrane-associated and soluble CD48
Pahima, H.; Zaffran, I.; Ben-Chetrit, E.; Jarjoui, A.; Gaur, P.; Manca, M. L.; Reichmann, D.; Orenbuch-Harroch, E.; Puxeddu, I.; Zinner, C.; Tzankov, A.; Levi-Schaffer, F.
10.1101/2022.03.18.484843 — immunology — Posted on 2022-03-19
1702 Timely sleep coupling: spindle-slow wave synchrony is linked to early amyloid-β burden and predicts memory decline
Chylinski, D.; Van Egroo, M.; Narbutas, J.; Muto, V.; Bahri, M. A.; Berthomier, C.; Salmon, E.; Bastin, C.; Phillips, C.; Collette, F.; Maquet, P.; Carrier, J.; Lina, J.-M.; Vandewalle, G.
10.1101/2022.03.15.484463 — neuroscience — Posted on 2022-03-19
1703 Transcriptomic analysis of the C3-CAM transition in Cistanthe longiscapa, a drought tolerant plant in the Atacama Desert
Ossa, P.; Moreno, A. A.; Daniela, O. M.; Toro, M.; Carrasco-Valenzuela, T.; Riveros, A.; Meneses, C.; Nilo-Poyanco, R.; Orellana, A.
10.1101/2022.03.16.484649 — plant biology — Posted on 2022-03-19
1706 Alpha-mannosidase-2 modulates arbovirus infection in a pathogen- and Wolbachia-specific manner in Aedes aegypti mosquitoes
Urakova, N.; Joseph, R. E.; Huntsinger, A.; Macias, V. M.; Jones, M. J.; Sigle, L. T.; Li, M.; Akbari, O. S.; Xi, Z.; Lymperopoulos, K.; Sayre, R. T.; McGraw, E. A.; Rasgon, J. L.
10.1101/2022.03.18.484928 — microbiology — Posted on 2022-03-19
1708 Cancer malignancy is correlated with up-regulation of PCYT2-mediated glycerol phosphate modification of α-dystroglycan
Umezawa, F.; Natsume, M.; Fukusada, S.; Nakajima, K.; Yamasaki, F.; Kawashima, H.; Kuo, C.-W.; Khoo, K.-H.; Shimura, T.; Yagi, H.; Kato, K.
10.1101/2021.10.25.465649 — biochemistry — Posted on 2022-03-19
1710 STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
Dinarello, A.; Betto, R. M.; Diamante, L.; Cioccarelli, C.; Meneghetti, G.; Peron, M.; Tesoriere, A.; Laquatra, C.; Tiso, N.; Martello, G.; Argenton, F.
10.1101/2021.11.19.469257 — developmental biology — Posted on 2022-03-18
1714 Transcriptomic similarity in the mouse and human brain
Beauchamp, A.; Yee, Y.; Darwin, B.; Raznahan, A.; Mars, R. B.; Lerch, J. P.
10.1101/2022.03.18.484766 — neuroscience — Posted on 2022-03-18
1715 Biocompatible polymers for scalable production of human neural organoids
Narazaki, G.; Miura, Y. P.; Pavlov, S. D.; Thete, M. V.; Roth, J. G.; Shin, S.; Heilshorn, S.; Pasca, S. P.
10.1101/2022.03.18.484949 — neuroscience — Posted on 2022-03-18
1718 Protein degradation sets the fraction of active ribosomes at vanishing growth
Calabrese, L.; Grilli, J.; Osella, M.; Kempes, C. P.; Cosentino Lagomarsino, M.; Ciandrini, L.
10.1101/2021.03.25.436692 — systems biology — Posted on 2022-03-18
1720 START domain mediates Arabidopsis GLABRA2 transcription factor dimerization and turnover independently of homeodomain DNA binding
Mukherjee, T.; Subedi, B.; Khosla, A.; Begler, E. M.; Stephens, P. M.; Warner, A. L.; Lerma-Reyes, R.; Thompson, K. A.; Gunewardena, S.; Schrick, K.
10.1101/2021.11.23.469727 — plant biology — Posted on 2022-03-18
1721 Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease
Stouffer, K.; Witter, M.; Chen, C.; Xu, E.; Albert, M.; Mori, S.; Troncoso, J.; Tward, D. J.; Miller, M.
10.1101/2022.03.16.484623 — bioengineering — Posted on 2022-03-18
1722 Substantial genetic mixing among sexual and androgenetic lineages within the clam genus Corbicula
Vastrade, M.; Etoundi, E.; Bournonville, T.; Colinet, M.; Debortoli, N.; Hedtke, S. M.; Nicolas, E.; Pigneur, L.-M.; Virgo, J.; Flot, J.-F.; Marescaux, J.; Van Doninck, K.
10.1101/590836 — evolutionary biology — Posted on 2022-03-18
1725 Flexible estimation of biodiversity with short-range multispectral imaging in a temperate grassland
Jackson, J.; Lawson, C. S.; Adelmant, C.; Huhtala, E.; Williamson, L.; Fernandes, P.; Hodgson, R.; King, H.; Maseyk, K.; Hawes, N.; Hector, A.; Salguero-Gomez, R.
10.1101/2022.03.08.483493 — ecology — Posted on 2022-03-18
1726 The isoforms of pyruvate kinase act as nutrient sensors for the β-cell KATP channel
Foster, H. R.; Ho, T.; Potapenko, E.; Sdao, S. M.; Lewandowski, S. L.; VanDeusen, H. R.; Davidson, S. M.; Cardone, R. L.; Kibbey, R. G.; Merrins, M. J.
10.1101/2022.02.09.478817 — cell biology — Posted on 2022-03-18
1730 A novel automated morphological analysis of microglia activation using a deep learning assisted model
Stetzik, L.; Mercado, G.; Smith, L.; George, S.; Quansah, E.; Luda, K.; Schulz, E.; Meyerdirk, L.; Lindquist, A.; Bergsma, A.; Jones, R.; Brundin, L.; Henderson, M.; Pospisilik, J. A.; Brundin, P.
10.1101/2022.03.11.483994 — neuroscience — Posted on 2022-03-18
1735 DNA co-methylation has a stable structure and is related to specific aspects of genome regulation
Watkins, S. H.; Suderman, M.; Hemani, G.; Burrows, K.; Lawlor, D. A.; West, J.; Willan, K.; Timpson, N. J.; Min, J.; Gaunt, T. R.
10.1101/2022.03.16.484648 — bioinformatics — Posted on 2022-03-18
1736 A single-cell clusters similarity measure for different batches, datasets, and samples
Gonzalez-Velasco, O.; Sanchez-Luis, E.; De La Rosa, E.; Sanchez-Santos, J. M.; De Las Rivas, J.
10.1101/2022.03.14.483731 — bioinformatics — Posted on 2022-03-18
1738 Genetic and environmental drivers of large-scale epigenetic variation in Thlaspi arvense
Galanti, D.; Ramos-Cruz, D.; Nunn, A.; Rodriguez-Arevalo, I.; Scheepens, J. F.; Becker, C.; Bossdorf, O.
10.1101/2022.03.16.484610 — evolutionary biology — Posted on 2022-03-18
1739 Synchrony and idiosyncrasy in the gut microbiome of wild baboons
Bjork, J. R.; Dasari, M. R.; Roche, K.; Grieneisen, L.; Gould, T. J.; Grenier, J.-C.; Yotova, V.; Gottel, N.; Jansen, D.; Gesquiere, L. R.; Gordon, J. B.; Learn, N. H.; Wango, T. L.; Mututua, R. S.; Warutere, J. K.; Siodi, L. i.; Mukherjee, S.; Barreiro, L. B.; Alberts, S. C.; Gilbert, J. A.; Tung, J.; Blekhman, R.; Archie, E.
10.1101/2021.11.24.469913 — ecology — Posted on 2022-03-18
1740 DISTINCTIVE FEATURES OF THE RESPIRATORY SYNCYTIAL VIRUS PRIMING LOOP COMPARED TO OTHER NON-SEGMENTED NEGATIVE STRAND RNA VIRUSES
Cressey, T. N.; Shareef, A. M.; Kleiner, V. A.; Noton, S. L.; Byrne, P. O.; McLellan, J. S.; Muhlberger, E.; Fearns, R.
10.1101/2022.03.18.484858 — microbiology — Posted on 2022-03-18
1741 Plasma iron controls neutrophil production and function
Frost, J. N.; Wideman, S. K.; Preston, A. E.; Teh, M. R.; Ai, Z.; Wang, L.; Cross, A.; White, N.; Yazicioglu, Y.; Bonadonna, M.; Clarke, A.; Armitage, A. E.; Galy, B.; Udalova, I. A.; Drakesmith, H.
10.1101/2022.03.17.484503 — immunology — Posted on 2022-03-18
1742 Water influx is required for CD4+ T cell activation and T cell-dependent antibody responses
Biggs O'May, J.; Vanes, L.; Hartweger, H.; de Boer, L.; Hayward, D.; Koechl, R.; Tybulewicz, V.
10.1101/2022.03.16.484637 — immunology — Posted on 2022-03-18
1743 DUF581-9 (At2g44670; FLZ3) negatively regulates SnRK1 activity by interference with T-loop phosphorylation
Bortlik, J.; Luehle, J.; Alseekh, S.; Weiste, C.; Fernie, A.; Droege-Laser, W.; Boernke, F.
10.1101/2022.03.17.484690 — plant biology — Posted on 2022-03-18
1744 Mesembryanthemum crystallinum plasma membrane root aquaporins are regulated via clathrin-coated vesicles in response to salt stress
Gomez Mendez, M. F.; Vera-Estrella, R.; Amezcua Romero, J. C.; Rosas Santiago, P.; Hernandez Dominguez, E. E.; de Luna Valdez, L. A.; Pantoja, O.
10.1101/2022.03.16.484672 — plant biology — Posted on 2022-03-18
1747 Extracellular matrix guidance determines proteolytic and non-proteolytic cancer cell patterning
Beunk, L.; van Helvert, S.; Bekker, B.; Ran, L.; Kang, R.; Paulat, T.; Syga, S.; Deutsch, A.; Friedl, P.; Wolf, K.
10.1101/2022.03.16.484647 — cancer biology — Posted on 2022-03-18
1748 Gene expression signature of castrate resistant prostate cancer
J M, D. J. S.; Hegde, S. S.; Tamboli, N.; Nadig, N.; Ramaiah, K.; Ranganathan, P.
10.1101/2022.03.16.484397 — cancer biology — Posted on 2022-03-18
1749 Topological action potentials in engineered tissues
Ori, H.; Duque Ramirez, M.; Hayward, R. F.; Tian, H.; Ortiz, G.; Cohen, A. E.
10.1101/2022.03.16.484369 — biophysics — Posted on 2022-03-18
1750 Hsp multichaperone complex buffers pathologically modified Tau
Moll, A.; Ramirez, L.-M.; Ninov, M.; Schwarz, J.; Urlaub, H.; Zweckstetter, M.
10.1101/2022.03.18.484853 — biophysics — Posted on 2022-03-18
1754 Engineering Principles and Algorithmic Design Synthesis for Ultracompact Bio-Hybrid Perfusion Chip
Erben, A.; Kellerer, T.; Lissner, J.; Eulenkamp, C.; Hellerer, T.; Clausen-Schaumann, H.; Sudhop, S.; Heymann, M.
10.1101/2022.03.16.484492 — bioengineering — Posted on 2022-03-18
1755 Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages
Huffman, R. G.; Leduc, A.; Wichmann, C.; di Gioia, M.; Borriello, F.; Specht, H.; Derks, J.; Khan, S.; Emmott, E.; Petelski, A. A.; Perlman, D. H.; Cox, J.; Zanoni, I.; Slavov, N.
10.1101/2022.03.16.484655 — bioengineering — Posted on 2022-03-18
1756 Long-term memory in frog-eating bats
Dixon, M. M.; Jones, P. L.; Ryan, M. J.; Carter, G. G.; Page, R. A.
10.1101/2022.03.16.484498 — animal behavior and cognition — Posted on 2022-03-18
1757 Control algorithms underlying the translational optomotor response
Holman, J. G.; Lai, W. W. K.; Pichler, P.; Saska, D.; Lagnado, L.; Buckley, C. L.
10.1101/2022.03.16.484575 — animal behavior and cognition — Posted on 2022-03-18
1758 Novel Murine models of Mania and Depression
Chen, B.; Xia, M.; Ji, M.; Gong, W.; Zhang, D.; Li, X.; Wang, S.; Feng, Y.; Wu, X.; Cui, L.; Verkhratsky, A.; Li, B.
10.1101/2022.03.16.484557 — animal behavior and cognition — Posted on 2022-03-18
1763 Modification of the SUMO activating enzyme subunit SAE2 directs SUMO isoform bias required for mitotic fidelity.
Walker, A.; Lanz, A.; Jamshad, M.; Garvin, A. J.; Wotherspoon, P.; Cooper, B. F.; Knowles, T. J.; Morris, J. R.
10.1101/2022.03.18.484840 — molecular biology — Posted on 2022-03-18
1764 Post-transcriptional regulation by copper with a new upstream Open Reading Frame
Roy, G.; Antoine, R.; Schwartz, A.; Slupek, S.; Rivera-Millot, A.; Boudvillain, M.; Jacob-Dubuisson, F.
10.1101/2022.03.18.484875 — microbiology — Posted on 2022-03-18
1766 Bidirectional regulation between AP-1 and SUMO genes modulates inflammatory signaling during Salmonella Typhimurium infection
Kumar, P.; Soory, A.; Mustfa, S. A.; Sarmah, D. T.; Chatterjee, S.; Bossis, G.; Ratnaparkhi, G. S.; Srikanth, C.
10.1101/2022.03.18.484857 — microbiology — Posted on 2022-03-18
1767 Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells.
Riegel, D.; Romero-Fernandez, E.; Simon, M.; Adenugba, A. R.; Singer, K.; Mayr, R.; Weber, F.; Imbusch, C. D.; Kreutz, M.; Brors, B.; Ugele, I.; Werner, J. M.; Siska, P. J.; Schmidl, C.
10.1101/2022.03.16.484513 — immunology — Posted on 2022-03-18
1768 High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
Gooch, H. M.; Bluett, T.; Perumal, M. B.; Vo, H. D.; Fletcher, L. N.; Papacostas, J.; Jeffree, R. L.; Wood, M.; Colditz, M. J.; McMillen, J.; Tsahtsarlis, T.; Amato, D.; Campbell, R.; Gillinder, L.; Williams, S. R.
10.1101/2022.03.16.484669 — neuroscience — Posted on 2022-03-18
1775 Interface resistance of biomolecular condensates
Zhang, Y.; Pyo, A. G. T.; Jiang, Y.; Brangwynne, C. P.; Stone, H. A.; Wingreen, N. S.
10.1101/2022.03.16.484641 — biophysics — Posted on 2022-03-18
1780 Hiplot: a comprehensive and easy-to-use web service boosting publication-ready biomedical data visualization
Li, J.; Miao, B.; Wang, S.; Dong, W.; Xu, H.; Si, C.; Wang, W.; Duan, S.; Lou, J.; Bao, Z.; Zeng, H.; Yang, Z.; Cheng, W.; Zhao, F.; Zeng, J.; Liu, X.-S.; Wu, R.; Shen, Y.; Chen, Z.; Chen, S.; Wang, M.
10.1101/2022.03.16.484681 — bioinformatics — Posted on 2022-03-18
1781 Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
Zhang, H.; Wang, L.; Cui, J.; Wang, S.; Han, Y.; Shao, H.; Wang, C.; Hu, Y.; Li, X.; Zhou, Q.; Guo, J.; Zhuang, X.; Sheng, S.; Zhang, T.; Zhou, D.; Chen, J.; Wang, F.; Gao, Q.; Jing, Y.; Chen, X.; Su, J.
10.1101/2022.03.17.484053 — biochemistry — Posted on 2022-03-18
1782 Per-Pathogen Virulence of HIV-1 subtypes A, C and D
Bouman, J. A.; Venner, C.; Walker, C.; Arts, E. J.; Regoes, R. R.
10.1101/2022.03.18.484874 — evolutionary biology — Posted on 2022-03-18
1785 A naturally arising broad and potent CD4-binding site antibody with low somatic mutation
Barnes, C. O.; Schoofs, T.; Gnanapragasam, P. N. P.; Golijanin, J.; Huey-Tubman, K. E.; Gruell, H.; Schommers, P.; Suh-Toma, N.; Lee, Y. E.; Lorenzi, J. C. C.; Piechocka-Trocha, A.; Scheid, J. F.; West, A. P.; Walker, B. D.; Seaman, M. S.; Klein, F.; Nussenzweig, M. C.; Bjorkman, P. J.
10.1101/2022.03.16.484662 — immunology — Posted on 2022-03-18
1787 Local actuation of organoids by magnetic nanoparticles
Abdel Fattah, A. R.; Kolaitis, N.; Van Daele, K.; Rustandi, G.; Ranga, A.
10.1101/2022.03.17.484696 — developmental biology — Posted on 2022-03-18
1788 Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function
Balazova, M.; Babelova, L.; Durisova, I.; Vesela, P.; Kanovicova, P.; Zahumensky, J.; Malinsky, J.
10.1101/2022.03.18.484854 — cell biology — Posted on 2022-03-18
1792 Large-scale analysis of SARS-CoV-2 synonymous mutations reveals the adaptation to the human codon usage during the virus evolution
Ramazzotti, D.; Angaroni, F.; Maspero, D.; Mauri, M.; D'Aliberti, D.; Fontana, D.; Antoniotti, M.; Elli, E. M.; Graudenzi, A.; Piazza, R.
10.1101/2021.04.23.441151 — bioinformatics — Posted on 2022-03-18
1794 Rethinking the role of intraspecific variability in species coexistence
Girard-Tercieux, C.; Marechaux, I.; Clark, A. T.; Clark, J. S.; Courbaud, B.; Fortunel, C.; Guillemot, J.; Kunstler, G.; le Maire, G.; Pelissier, R.; Rueger, N.; Vieilledent, G.
10.1101/2022.03.16.484259 — ecology — Posted on 2022-03-18
1795 Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains
Case, J. B.; Mackin, S.; Errico, J.; Chong, Z.; Madden, E. A.; Guarino, B.; Schmid, M. A.; Rosenthal, K.; Ren, K.; Jung, A.; Droit, L.; Handley, S. A.; Halfmann, P. J.; Kawaoka, Y.; Crowe, J. E.; Fremont, D. H.; Virgin, H. W.; Loo, Y.-M.; Esser, M. T.; Purcell, L. A.; Corti, D.; Diamond, M. S.
10.1101/2022.03.17.484787 — microbiology — Posted on 2022-03-18
1796 SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties
Fenwick, C.; Turelli, P.; Ni, D.; Perez, L.; Lau, K.; Lana, E.; Pellaton, C.; Raclot, C.; Esteves-Leuenberger, L.; Campos, J.; Farina, A.; Fiscalini, F.; Herate, C.; Marlin, R.; Abdelnabi, R.; Foo, C. S.-Y.; Neyts, J.; Leyssen, P.; LeGrand, R.; Levy, Y.; Pojer, F.; Stahlberg, H.; Trono, D.; Pantaleo, G.
10.1101/2022.03.18.484873 — immunology — Posted on 2022-03-18
1797 Prime-boost vaccinations with two serologically distinct chimpanzee adenovirus vectors expressing SARS-CoV-2 spike or nucleocapsid tested in a hamster COVID-19 model
Hasanpourghadi, M.; Novikov, M.; Ambrose, R.; Chekaoui, A.; Newman, D.; Ding, J.; Giles-Davis, W.; Xiang, Z.; Zhou, X.; Liu, Q.; Swagata, K.; Ertl, H. C. J.
10.1101/2022.03.17.484786 — immunology — Posted on 2022-03-18
1799 Automated neuron tracking inside moving and deforming animals using deep learning and targeted augmentation
Park, C. F.; Keshteli, M. B.; Korchagina, K.; Delrocq, A.; Susoy, V.; Jones, C. L.; Samuel, A. D. T.; Rahi, S. J.
10.1101/2022.03.15.484536 — neuroscience — Posted on 2022-03-18
1801 Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice
Ren, P.; Peng, L.; Fang, Z.; Suzuki, K.; Renauer, P. A.; Lin, Q.; Bai, M.; Yang, L.; Li, T.; Clark, P.; Klein, D.; Chen, S.
10.1101/2022.03.17.484817 — bioengineering — Posted on 2022-03-18
1803 Gut microbiota composition in colorectal cancer patients is genetically regulated
Colombo, F.; Pomposo, O.; Noci, S.; Minnai, F.; Pintarelli, G.; Pettinicchio, A.; Vannelli, A.; Sorrentino, L.; Battaglia, L.; Cosimelli, M.; Dragani, T. A.; Gariboldi, M.
10.1101/2022.03.16.484560 — genetics — Posted on 2022-03-18
1805 Chimeric mRNA based COVID-19 vaccine induces protective immunity against Omicron and Delta
Hu, Q.; Zhao, Y.; Shaabani, N.; Lyu, X.; Sun, H.; Cruz, V.; Kao, Y.; Xu, J.; Fossier, A.; Stegman, K.; Wang, Z.; Wang, Z.; Hu, Y.; Zheng, Y.; Kyaw, L.; Zuluaga, C.; Wang, H.; Pei, H.; Powers, C.; Allen, R.; Xie, H.; Ji, H.; Chen, R.
10.1101/2022.03.04.483032 — immunology — Posted on 2022-03-18
1806 IRON REGULATORY PROTEIN (IRP)-MEDIATED IRON HOMEOSTASIS IS CRITICAL FOR NEUTROPHIL DEVELOPMENT AND DIFFERENTIATION IN THE BONE MARROW
Bonadonna, M.; Altamura, S.; Tybl, E.; Palais, G.; Qatato, M.; Polycarpou-Schwarz, M.; Schneider, M.; Kalk, C.; Ruediger, W.; Ertl, A.; Anstee, N.; Bogeska, R.; Helm, D.; Milsom, M. D.; Galy, B.
10.1101/2022.03.16.483971 — immunology — Posted on 2022-03-18
1807 Subjectivity of time perception alters choice preference for future rewards through fronto-striatal value signal dynamics
Shintaki, R.; Tanaka, D.; Okayasu, M.; Suzuki, S.; Yoshimoto, T.; Sadato, N.; Chikazoe, J.; Jimura, K.
10.1101/2022.03.16.484555 — neuroscience — Posted on 2022-03-18
1810 Resolving the mesoscopic missing link: Biophysical modeling of EEG from cortical columns in primates
Herrera, B.; Westerberg, J. A.; Schall, M. S.; Maier, A.; Woodman, G. F.; Schall, J. D.; Riera, J. J.
10.1101/2022.03.16.484595 — neuroscience — Posted on 2022-03-18
1814 -Labeled PARP-1 PET Imaging of PSMA Targeted Alpha Particle Radiotherapy Response
Zhang, H.; Abou, D.; Villmer, A.; Benabdallah, N.; Jiang, W.; Ulmert, D.; Carlin, S.; Rogers, B. E.; Turtle, N. F.; McDevitt, M.; Baumann, B.; Simons, B. W.; Zhou, D.; Thorek, D. L.
10.1101/2022.03.16.484613 — cancer biology — Posted on 2022-03-18
1815 Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis: a comparative study.
Reshetnikov, K. O.; Bykova, D. I.; Kuleshov, K. V.; Chukreev, K.; Guguchkin, E. P.; Akimkin, V. G.; Neverov, A. D.; Fedonin, G. G.
10.1101/2022.03.16.484601 — bioinformatics — Posted on 2022-03-18
1818 Case-control analysis of single-cell RNA-seq studies
Petukhov, V.; Igolkina, A. A.; Rydbirk, R.; Mei, S.; Christoffersen, L.; Khodosevich, K.; Kharchenko, P.
10.1101/2022.03.15.484475 — bioinformatics — Posted on 2022-03-18
1820 Optimization of the precursor supply for an enhanced FK-506 production in Streptomyces tsukubaensis
Schulz, S.; Schall, C.; Stehle, T.; Breitmeyer, C.; Krysenko, S.; Bera, A.; Wohlleben, W.
10.1101/2022.03.16.484622 — bioengineering — Posted on 2022-03-18
1822 Integrated protein and transcriptome high-throughput spatial profiling
Ben Chetrit, N.; Niu, X.; Swett, A. D.; Sotelo, J.; Jiao, M. S.; Roelli, P.; Stoeckius, M.; Landau, D. A.
10.1101/2022.03.15.484516 — genomics — Posted on 2022-03-18
1823 DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
Shireby, G.; Dempster, E.; Policicchio, S.; Smith, R.; Pishva, E.; Chioza, B.; Davies, J.; Burrage, J.; Lunnon, K.; Seiler-Vellame, D.; Love, S.; Thomas, A.; Brookes, K.; Morgan, K.; Francis, P.; Hannon, E.; Mill, J.
10.1101/2022.03.15.484508 — genetics — Posted on 2022-03-18
1827 Xanthomonas indica sp. nov., a non-pathogenic bacterium isolated from healthy rice (Oryza sativa) seeds from India
Rana, R.; Madhavan, V. N.; Saroha, T.; Bansal, K.; Kaur, A.; Sonti, R. V.; Patel, H. K.; Patil, P. B.
10.1101/2022.03.16.484583 — evolutionary biology — Posted on 2022-03-18
1828 Beyond inappropriate fire regimes: a synthesis of fire-driven declines of threatened mammals in Australia
Santos, J. L.; Hradsky, B. A.; Keith, D. A.; Rowe, K.; Senior, K. L.; Sitters, H.; Kelly, L. T.
10.1101/2022.03.15.483873 — ecology — Posted on 2022-03-18
1829 Engineering ecologically complementary rhizosphere probiotics using consortia of specialized bacterial mutants
Yang, C.; Li, J.; Jousset, A.; Wang, X.; Xu, Z.; Yang, T.; Mei, X.; Zhong, Z.; Xu, Y.; Shen, Q.; Wei, Z.; Friman, V.-P.
10.1101/2022.03.16.484597 — ecology — Posted on 2022-03-18
1832 T cell migration requires ion and water influx to regulate actin polymerization
de Boer, L.; Melgrati, S.; Vanes, L.; Biggs O'May, J.; Hayward, D.; Koechl, R.; Tybulewicz, V.
10.1101/2022.03.16.484584 — immunology — Posted on 2022-03-18
1836 Saturated reconstruction of living brain tissue
Velicky, P.; Miguel, E.; Michalska, J. M.; Wei, D.; Lin, Z.; Watson, J. F.; Troidl, J.; Beyer, J.; Ben-Simon, Y.; Sommer, C.; Jahr, W.; Cenameri, A.; Broichhagen, J.; Grant, S. G. N.; Jonas, P.; Novarino, G.; Pfister, H.; Bickel, B.; Danzl, J. G.
10.1101/2022.03.16.484431 — neuroscience — Posted on 2022-03-18
1845 GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight in obese mice
Sachs, S.; Goetz, A.; Finan, B.; DiMarchi, R. D.; Doering, Y.; Weber, C.; Tschoep, M.; Mueller, T. D.; Hofmann, S. M.
10.1101/2022.03.15.484530 — pharmacology and toxicology — Posted on 2022-03-18
1846 Dual blockade of misfolded alpha-sarcoglycan degradation by bortezomib and givinostat combination
Hoch, L.; Bourg, N.; Degrugillier, F.; Bruge, C.; Benabides, M.; Pellier, E.; Tournois, J.; Mahe, G.; Maignan, N.; Dawe, J.; Georges, M.; Papazian, D.; Subramanian, N.; Simon, S.; Fanen, P.; Delevoye, C.; Richard, I.; Nissan, X.
10.1101/2022.03.16.484594 — pharmacology and toxicology — Posted on 2022-03-18
1849 Adversarial attacks and adversarial robustness in computational pathology
Ghaffari Laleh, N.; Truhn, D.; Veldhuizen, G. P.; Han, T.; van Treeck, M.; Buelow, R. D.; Langer, R.; Dislich, B.; Boor, P.; Schulz, V.; Kather, J. N.
10.1101/2022.03.15.484515 — bioinformatics — Posted on 2022-03-18
1850 Unsupervised discovery of tissue architecture in multiplexed imaging
Kim, J.; Rustam, S.; Mosquera, J. M.; Randell, S. H.; Shaykhiev, R.; Rendeiro, A. F.; Elemento, O.
10.1101/2022.03.15.484534 — bioinformatics — Posted on 2022-03-18
1852 Cavitation Induced Fracture of Intact Brain Tissue
Dougan, C.; Song, Z.; Fu, H.; Crosby, A. J.; Cai, S.; Peyton, S.
10.1101/2022.03.15.484522 — bioengineering — Posted on 2022-03-18
1855 Identification of touch neurons underlying dopaminergic pleasurable touch and sexual receptivity
Elias, L. J.; Schaffler, M.; Succi, I.; Foster, W.; Gradwell, M.; Bohic, M.; Ejoh, L.; Abraira, V.; Abdus-Saboor, I.
10.1101/2021.09.22.461355 — neuroscience — Posted on 2022-03-18
1856 Differential impact of mutations in cell cycle checkpoint kinases on breast cancer presentation and prognosis.
Punturi, S.; Punturi, N.; Carrel, S. J.; Mazumder, A.; Fusco, N.; Bainbridge, M.; Haricharan, S.
10.1101/2020.10.29.361352 — cancer biology — Posted on 2022-03-18
1858 SARS-CoV-2 Can Infect Human Embryos
Montano, M.; Victor, A. R.; Griffin, D. K.; Duong, T.; Bolduc, N.; Farmer, A.; Garg, V.; Hadjantonakis, A.-K.; Coates, A.; Barnes, F. L.; Zouves, C. G.; Greene, W. C.; Viotti, M.
10.1101/2021.01.21.427501 — developmental biology — Posted on 2022-03-18
1859 NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
Tille, L.; Cropp, D.; Bodley, G.; Andreatta, M.; Charmoy, M.; Crespo-Casajus, I.; Nassiri, S.; Lourenco, J.; Leblond, M. M.; Lopez-Rodriguez, C.; Speiser, D. E.; Carmona, S. J.; Held, W.; Verdeil, G.
10.1101/2022.03.15.484422 — immunology — Posted on 2022-03-18
1867 Flexible estimation of biodiversity with short-range multispectral imaging in a temperate grassland
Jackson, J.; Lawson, C. S.; Adelmant, C.; Huhtala, E.; Williamson, L.; Fernandes, P.; Hodgson, R.; King, H.; Maseyk, K.; Hawes, N.; Hector, A.; Salguero-Gomez, R.
10.1101/2022.03.08.483493 — ecology — Posted on 2022-03-18
1869 Structural insights into the regulation of acetylation-dependent genome condensation
Ibrahim, Z.; Wang, T.; Destaing, O.; Salvi, N.; Hoghoughi, N.; Rusu, A. D.; Gao, J.; Feletto, L.; Reynoird, N.; Schalch, T.; Zhao, Y.; Blackledge, M.; Khochbin, S.; Panne, D.
10.1101/2022.03.14.484228 — biochemistry — Posted on 2022-03-18
1870 Genomics epidemiology analysis reveals hidden signatures of drug resistance in Mycobacterium tuberculosis
Mejia-Ponce, P. M.; Ramos-Gonzalez, E. J.; Ramos-Garcia, A. A.; Lara-Ramirez, E. E.; Soriano-Herrera, A. R.; Medellin-Luna, M. F.; Valdez-Salazar, F.; Castro-Garay, C. Y.; Nunez-Contreras, J. d. J.; De Donato-Capote, M.; Sharma, A.; Castaneda-Delgado, J. E.; ZENTENO-CUEVAS, R.; Enciso-Moreno, J. A.; Licona-Cassani, C.
10.1101/2022.03.15.484552 — genomics — Posted on 2022-03-18
1872 MDA-LDL vaccination induces athero-protective germinal center-derived antibody responses
Martos-Folgado, I.; Lorenzo, C.; Busse, C. E.; Delgado, P.; Mur, S. M.; Cobos, L.; Martin-Ventura, J. L.; Escola-Gil, J. C.; Wardemann, H.; Ramiro, A. R.
10.1101/2021.10.25.465690 — immunology — Posted on 2022-03-18
1873 SPCS: A Spatial and Pattern Combined Smoothing Method of Spatial Transcriptomic Expression
Liu, Y.; Wang, T.; Duggan, B.; Sharpnack, M.; Huang, K.; Zhang, J.; Ye, X.; Johnson, T.
10.1101/2021.11.02.467030 — bioinformatics — Posted on 2022-03-18
1874 Plasmid stability in fluctuating environments:population genetics of multi-copy plasmids
Miro Pina, V.; Hernandez-Beltran, J. C. R.; Siri-Jegousse, A.; Palau, S.; Pena-Miller, R.; Gonzalez-Casanova, A.
10.1101/2022.03.15.484385 — evolutionary biology — Posted on 2022-03-18
1876 Systematic evaluation of cell-type deconvolution pipelines for sequencing-based bulk DNA methylomes
Jeong, Y.; Barros de Andrade e Sousa, L.; Thalmeier, D.; Toth, R.; Ganslmeier, M.; Breuer, K.; Plass, C.; Lutsik, P.
10.1101/2021.11.29.470374 — bioinformatics — Posted on 2022-03-18
1877 Identification of m6A and m5C RNA modifications at single-molecule resolution from Nanopore sequencing
Acera Mateos, P.; Sethi, A. J.; Guarnacci, M.; Ravindran, A.; Srivastava, A.; Xu, J.; Woodward, K.; Hamilton, W.; Gao, J.; Starrs, L. M.; Hayashi, R.; Burgio, G.; Wickramasinghe, V. O.; Dehorter, N.; Preiss, T.; Shirokikh, N. E.; Eyras, E.
10.1101/2022.03.14.484124 — bioinformatics — Posted on 2022-03-18
1878 A brain-wide analysis maps structural evolution to distinct anatomical modules
Kozol, R. A.; Conith, A. J.; Yuiska, A.; Cree-Newman, A.; Tolentino, B.; Banesh, K.; Paz, A.; Lloyd, E.; Kowalko, J. E.; Keene, A. C.; Albertson, R. C.; Duboue, E.
10.1101/2022.03.17.484801 — neuroscience — Posted on 2022-03-18
1879 Visual Attention in The Fovea and The Periphery during Visual Search
Zhang, J.; Zhu, X.; Wang, S.; Ma, Z.; Esteky, H.; Tian, Y.; Desimone, R.; Zhou, H.
10.1101/2021.11.22.469359 — neuroscience — Posted on 2022-03-18
1881 Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule
Maseko, S.; Van Molle, I.; Blibek, K.; Gorgulla, C.; Olivet, J.; Blavier, J.; Vandermeulen, C.; Skupiewski, S.; Saha, D.; Ntombela, T.; Lim, J.; Lembo, F.; Beauvois, A.; Hamaidia, M.; Borg, J.-P.; Zimmermann, P.; Delvigne, F.; Willems, L.; Van Weyenbergh, J.; Kim, D.-K.; Dequiedt, F.; Arthanari, H.; Salehi-Ashtiani, K.; Ballet, S.; Volkov, A.; Twizere, J.-C.
10.1101/2021.08.25.457680 — biochemistry — Posted on 2022-03-18
1885 slimr: An R package for integrating data and tailor-made population genomic simulations over space and time
Dinnage, R.; Sarre, S. D.; Duncan, R. P.; Dickman, C. R.; Edwards, S. V.; Greenville, A.; Wardle, G.; Gruber, B.
10.1101/2021.08.05.455258 — evolutionary biology — Posted on 2022-03-17
1886 Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships
Zbasnik, N.; Dolan, K.; Buczkowski, S. A.; Green, R.; Hallgrimsson, B.; Marcucio, R.; Moon, A. M.; Fish, J. L.
10.1101/2022.03.17.484804 — developmental biology — Posted on 2022-03-18
1887 Linking Parasitism to Network Centrality and the Impact of Sampling Bias in its Interpretation
XU, Z.; MacIntosh, A. J. J.; Castellano-Navarro, A.; Macanas-Martuinez, E.; Suzumura, T.; Duboscq, J.
10.1101/2021.06.07.447302 — animal behavior and cognition — Posted on 2022-03-17
1888 Dissecting the Pyrenophora tritici-repentis (tan spot of wheat) pangenome
Gourlie, R.; McDonald, M.; Hafez, M.; Ortega-Polo, R.; Low, K. E.; Abbott, D. W.; Strelkov, S.; Daayf, F.; Aboukhaddour, R.
10.1101/2022.03.07.483352 — genomics — Posted on 2022-03-17
1891 Many dissimilar protein domains switch between α-helix and β-sheet folds
Porter, L.; Kim, A. K.; Rimal, S.; Looger, L. L.; Majumdar, A.; Mensh, B.; Starich, M. R.
10.1101/2021.06.10.447921 — bioinformatics — Posted on 2022-03-17
1892 De-noising Spatial Transcriptomics Data Based on Position and Image Information
Wang, Y.; Song, B.; Wang, S.; Chen, M.; Xie, Y.; Xiao, G.; Wang, L.; Wang, T.
10.1101/2021.11.03.467103 — bioinformatics — Posted on 2022-03-17
1895 Directing iPSC Differentiation into iTenocytes using Combined Scleraxis Overexpression and Cyclic Loading
Papalamprou, A.; Yu, V.; Chen, A.; Stefanovic, T.; Kaneda, G.; Salehi, K.; Castaneda, C.; Gertych, A.; Glaeser, J. D.; Sheyn, D.
10.1101/2021.11.23.469329 — cell biology — Posted on 2022-03-17
1896 LiveCellMiner: A New Tool to Analyze Mitotic Progression
Moreno-Andres, D.; Bhattacharyya, A.; Scheufen, A.; Stegmaier, J.
10.1101/2021.11.17.469067 — cell biology — Posted on 2022-03-17
1903 Clathrin-mediated Endocytosis Facilitates Internalization of Magnaporthe oryzae Effectors into Rice Cells
Oliveira-Garcia, E.; Tamang, T. M.; Park, J.-E.; Dalby, M.; Martin-Urdiroz, M.; Rodriguez Herrero, C.; Hong Vu, A.; Park, S.; Talbot, N. J.; Valent, B.
10.1101/2021.12.28.474284 — plant biology — Posted on 2022-03-17
1905 UniFuncNet: a flexible network annotation framework
Queiros, P.; Hickl, O.; Martinez Arbas, S.; Wilmes, P.; May, P.
10.1101/2022.03.15.484380 — bioinformatics — Posted on 2022-03-17
1907 clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ
Dardani, I.; Emert, B. L.; Goyal, Y.; Jiang, C. L.; Kaur, A.; Lee, J.; Rouhanifard, S. H.; Alicea, G. M.; Fane, M. E.; Xiao, M.; Herlyn, M.; Weeraratna, A. T.; Raj, A.
10.1101/2022.03.16.484659 — bioengineering — Posted on 2022-03-17
1908 The DeepFaune initiative: a collaborative effort towards the automatic identification of the French fauna in camera-trap images
Rigoudy, N.; Benyoub, A.; Besnard, A.; Birck, C.; Bollet, Y.; Bunz, Y.; De Backer, N.; Caussimont, G.; Delestrade, A.; Dispan, L.; Elder, J.-F.; Fanjul, J.-B.; Fonderflick, J.; Garel, M.; Gaudry, W.; Gerard, A.; Gimenez, O.; Hemery, A.; Hemon, A.; Jullien, J.-M.; Le Barh, M.; Malafosse, I.; Randon, M.; Ribiere, R.; Ruette, S.; Terpereau, G.; Thuiller, W.; Vautrain, V.; Spataro, B.; Miele, V.; Chamaille-Jammes, S.
10.1101/2022.03.15.484324 — ecology — Posted on 2022-03-17
1909 The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference
Pochon, G.; Henry, I. M.; Yang, C.; Lory, N. C.; Fernandez-Jimenez, N.; Böwer, F.; Hu, B.; Carstens, L.; Tsai, H. T.; Pradillo, M.; Comai, L.; Schnittger, A.
10.1101/2022.03.17.484635 — cell biology — Posted on 2022-03-17
1910 Identification of Aspergillus niger aquaporins involved in hydrogen peroxide signaling
Laothanachareon, T.; Asin-Garcia, E.; Volkers, R. J. M.; Tamayo-Ramos, J. A.; Schaap, P. J.
10.1101/2022.03.16.484687 — molecular biology — Posted on 2022-03-17
1912 The faecal microbiome of the wild European badger Meles meles; a comparison against other wild omnivorous mammals from across the globe
Scott-Baumann, J.; Friedersdorff, J.; Villarreal Ramos, B.; King, J.; Hopkins, B.; Pizzey, R.; Rooke, D.; Hewinson, G.; Mur, L.
10.1101/2022.03.17.484750 — microbiology — Posted on 2022-03-17
1916 Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer
Brown, B. P.; Zhang, Y.; Kim, S.; Finneran, P.; Yan, Y.; Du, Z.; Kim, J.; Hartzler, A. L.; LeNoue-Newton, M. L.; Smith, A. W.; Meiler, J.; Lovly, C. M.
10.1101/2022.03.16.484661 — cancer biology — Posted on 2022-03-17
1918 Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain
Henot, F.; Rioual, E.; Favier, A.; Macek, P.; Crublet, E.; Josso, P.; Brutscher, B.; Frech, M.; Gans, P.; Loison, C.; Boisbouvier, J.
10.1101/2022.03.16.484593 — biophysics — Posted on 2022-03-17
1919 Groundwater metabolome responds to recharge in fractured sedimentary strata
Zerfass, C.; Lehmann, R.; Ueberschaar, N.; Sanchez-Arcos, C.; Totsche, K.-U.; Pohnert, G.
10.1101/2022.03.17.484695 — biochemistry — Posted on 2022-03-17
1923 Evaluating the potential benefits and pitfalls of combining protein and expression quantitative trait loci in evidencing drug targets
Robinson, J. W.; Battram, T.; Baird, D. A.; Haycock, P.; Zheng, J.; Hemani, G.; Chen, C.-Y.; Gaunt, T. R.
10.1101/2022.03.15.484248 — genetics — Posted on 2022-03-17
1925 Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract
Grantham, E.; Tiwari, G.; Ponomareva, O.; Warden, A.; DaCosta, A.; Mason, S.; Blednov, Y.; Harris, R. A.; Lopez, M. F.; Becker, H. C.; Mayfield, R. D.
10.1101/2022.03.17.484799 — molecular biology — Posted on 2022-03-17
1926 Acute Cytomegalovirus Infection Modulates the Intestinal Microbiota and Targets Intestinal Epithelial Cells
Le-Trilling, V. T. K.; Ebel, J.-F.; Baier, F.; Wohlgemuth, K.; Pfeifer, K. R.; Mookhoek, A.; Krebs, P.; Determann, M.; Kaschinski, B.; Adamczyk, A.; Lange, E.; Klopfleisch, R.; Lange, C. M.; Sokolova, V.; Trilling, M.; Westendorf, A. M.
10.1101/2022.03.17.484735 — microbiology — Posted on 2022-03-17
1928 A non-invasive method for time-lapse imaging of microbial interactions and biofilm dynamics
Molina-Santiago, C.; Pearson, J. R.; Berlanga-Clavero, M. V.; Perez-Lorente, A. I.; de Vicente, A.; Romero, D.
10.1101/2022.03.17.484708 — microbiology — Posted on 2022-03-17
1935 Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations
Huelsz-Prince, G.; Kok, R. N. U.; Goos, Y. J.; Bruens, L.; Zheng, X.; Ellenbroek, S. I. J.; van Rheenen, J.; Tans, S. J.; van Zon, J. S.
10.1101/2022.03.17.484731 — cell biology — Posted on 2022-03-17
1936 AtEH/Pan1 proteins drive phase separation of the TPLATE complex and clathrin polymerisation during plant endocytosis
Dragwidge, J. M.; Wang, Y.; Brocard, L.; De Meyer, A.; Hudecek, R.; Eeckhout, D.; Chambaud, C.; Pejchar, P.; Potocky, M.; Vandorpe, M.; Bernard, A.; De Jaeger, G.; Pleskot, R.; Fang, X.; Van Damme, D.
10.1101/2022.03.17.484738 — cell biology — Posted on 2022-03-17
1937 Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation
Salaun, C.; Takizawa, H.; Galindo, A.; Munro, K. R.; McLellan, J.; Sugimoto, I.; Okino, T.; Tomkinson, N. C. O.; Chamberlain, L. H.
10.1101/2022.03.17.484726 — cell biology — Posted on 2022-03-17
1939 Broad neutralization of SARS-CoV-2 variants by circular mRNA producing VFLIP-X spike in mice
Seephetdee, C.; Bhukhai, K.; Buasri, N.; Leelukkanaveera, P.; Lerdwattanasombat, P.; Manopwisedjaroen, S.; Phueakphud, N.; Kuhaudomlarp, S.; Ollmann Saphire, E.; Thitithanyanont, A.; Hongeng, S.; Wongtrakoongate, P.
10.1101/2022.03.17.484759 — immunology — Posted on 2022-03-17
1942 Long-term T cell perturbations and waning antibody levels in individuals needing hospitalization for COVID-19
Govender, M.; Hopkins, F. R.; Goransson, R.; Svanberg, C.; Muthu, S. E.; Hjorth, M.; Augustinsson, A. N.; Sjowall, J.; Nystrom, S.; Larsson, M.
10.1101/2022.03.17.484640 — immunology — Posted on 2022-03-17
1944 PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers
Aakula, A.; Isomursu, A.; Rupp, C.; Erickson, A.; Kauko, O.; Shah, P.; Padzik, A.; Pokharel, Y. R.; Kaur, A.; Li, S.-P.; Trottman, L.; Taimen, P.; Rannikko, A.; Lammerding, J.; Paatero, I.; Mirtti, T.; Ivaska, J.; Westermarck, J.
10.1101/581660 — cancer biology — Posted on 2022-03-17
1946 Epithelial-Mesenchymal Plasticity is regulated by inflammatory signalling networks coupled to cell morphology.
Arias-Garcia, M.; Yin, Z.; Roumeliotis, T. I.; Butera, F.; Wang, L.; Rickman, R. H.; Chaudhary, J. S.; Wong, S. T.; Yuan, Y.; Bakal, C.
10.1101/689737 — systems biology — Posted on 2022-03-17
1951 Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models
Dickson, E.; Dwijesha, A. S.; Andersson, N.; Lundh, S.; Bjorkqvist, M.; Petersen, A. S.; Soylu-Kucharz, R. S.
10.1101/2022.03.15.484411 — neuroscience — Posted on 2022-03-17
1952 Glucagon-like peptide-1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis
Steiner, A.; Owen, B. M.; Bauer, J. P.; Seanez, L.; Kwon, S.; Biddinger, J. E.; Huffman, R.; Ayala, J. E.; Nobis, W. P.; Lewis, A. S.
10.1101/2022.03.14.484169 — neuroscience — Posted on 2022-03-17
1953 Model-guided design of the diversity of a synthetic human gut community
Connors, B. M.; Ertmer, S.; Clark, R. L.; Thompson, J.; Pfleger, B. F.; Venturelli, O. S.
10.1101/2022.03.14.484355 — systems biology — Posted on 2022-03-17
1954 Heterogeneous multimeric metabolite ion species observed in LC-MS based metabolomics data sets
El Abiead, Y.; Bueschl, C.; Panzenboeck, L.; Wang, M.; Doppler, M.; Seidl, B.; Zanghellini, J.; Dorrestein, P. C.; Koellensperger, G.
10.1101/2022.03.15.484295 — systems biology — Posted on 2022-03-17
1958 UniFuncNet: a flexible network annotation framework
Queiros, P.; Hickl, O.; Wilmes, P.; May, P.; Martinez Arbas, S.
10.1101/2022.03.15.484380 — bioinformatics — Posted on 2022-03-17
1959 Fluximplied: A novel approach integrates rate limiting steps and differential expression for pathway analysis
Sportiello, M.; Geber, A.; Palli, R.; Embong, A. K.; Laniewski, N.; Reilly, E. C.; Lambert Emo, K.; Topham, D. J.
10.1101/2022.03.15.484417 — bioinformatics — Posted on 2022-03-17
1965 Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid Leukemia
Sanchez Martinez, D.; Tirado, N.; Mensurado, S.; Martinez-Moreno, A.; Romecin, P.; Gutierrez-Aguera, F.; Correia, D. V.; Silva-Santos, B.; Menendez, P.
10.1101/2022.03.15.484289 — immunology — Posted on 2022-03-17
1967 Angiotensin blockade enhances motivational reward learning via enhancing ventral striatal prediction error and frontostriatal communication
Xu, T.; Zhou, X.; Kanen, J. W.; Wang, L.; Chen, Z.; Zhang, R.; Jiao, G.; Feng, Z.; Zhao, W.; Yao, S.; Becker, B.
10.1101/2022.03.14.484364 — neuroscience — Posted on 2022-03-17
1968 Organ- and function-specific anatomical organization and bioelectronic modulation of the vagus nerve
Jayaprakash, N.; Toth, V.; Song, W.; Vardhan, A.; Levy, T.; Tomaio, J.; Qanud, K.; Mughrabi, I.; Saperstein, Y.; Chang, Y.-C.; Rob, M.; Daytz, A.; Abbas, A.; Ashville, J.; Vikatos, A.; Ahmed, U.; Nassrallah, Z.; Volpe, B.; Tracey, K. J.; Al-Abed, Y.; Datta-Chaudhuri, T.; Miller, L.; Barbe, M.; Lee, S.; Zanos, T.; Zanos, S.
10.1101/2022.03.07.483266 — neuroscience — Posted on 2022-03-17
1976 Selective V1-to-V4 communication of attended stimuli mediated by attentional effects in V1
Katsanevaki, C.; Bastos, A. M.; Cagnan, H.; Bosman, C. A.; Friston, K. J.; Fries, P.
10.1101/2022.03.14.484223 — neuroscience — Posted on 2022-03-17
1978 Mixture of Learning Strategies Underlies Rodent Behavior in Dynamic Foraging
Le, N. M.; Yildirim, M.; Wang, Y.; Sugihara, H.; Jazayeri, M.; Sur, M.
10.1101/2022.03.14.484338 — neuroscience — Posted on 2022-03-17
1979 Adenosine A1R/A3R Agonist AST-004 Reduces Brain Infarction in Mouse and Rat Models of Acute Ischemic Stroke
Fisher, E. S.; Chen, Y.; Sifuentes, M. M.; Stubblefield, J. J.; Lozano, D.; Holstein, D. M.; Ren, J.; DeRosa, N.; Chen, T.-P.; Nickel, G.; Liston, T. E.; Lechleiter, J. D.
10.1101/2022.03.14.484307 — neuroscience — Posted on 2022-03-17
1983 MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity
Nibeyro, G.; Girotti, M. R.; Prato, L.; Moron, V. G.; Lujan, H. D.; Fernandez, E. A.
10.1101/2022.03.14.484285 — bioinformatics — Posted on 2022-03-17
1985 Finding coarse and fine scale population structure in a coastal species: population demographics meets genomics
Catarino, D.; Jorde, P. E.; Rogers, L.; Albretsen, J.; Jahnke, M.; Sodeland, M.; Mellerud, I.; Andre, C.; Knutsen, H.
10.1101/2022.02.15.480495 — genomics — Posted on 2022-03-17
1986 Comparative miRNA Transcriptomics of Mouse and Macaque Reveals MYOC is An Inhibitor for C. neoformans Invasion into Brain
Li, H.; Han, X.; Du, W.; Meng, Y.; Li, Y.; Sun, T.; Liang, Q.; Li, C.; Suo, C.; Gao, X.; Qiu, Y.; Tian, W.; An, M.; Zhang, H.; Fu, Y.; Li, X.; Lan, T.; Yang, S.; Zhang, Z.; Geng, W.; Ding, C.; Shang, H.
10.1101/2022.02.14.480319 — microbiology — Posted on 2022-03-17
1987 Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster
Peng, P.; Feng, C.; Hu, J.; He, C.-l.; Deng, H.; Fan, Q.; Xiang, J.; Tang, G.; Jiang, M.; Hu, F.; Li, F.; Wang, K.; Tang, N.; Tang, X.; Huang, A.
10.1101/2022.03.07.483373 — microbiology — Posted on 2022-03-17
1988 Comparison of individualized behavioral predictions across anatomical, diffusion and functional connectivity MRI
Ooi, L. Q. R.; Chen, J.; Zhang, S.; Kong, R.; Tam, A.; Li, J.; Dhamala, E.; Zhou, J. H.; Holmes, A.; Yeo, B. T. T.
10.1101/2022.03.08.483564 — neuroscience — Posted on 2022-03-17
1990 Mechanism of R-loop formation and conformational activation of Cas9
Pacesa, M.; Loeff, L.; Querques, I.; Muckenfuss, L. M.; Sawicka, M.; Jinek, M.
10.1101/2021.09.16.460614 — biochemistry — Posted on 2022-03-17
1995 Optimized cultivar deployment improves the efficiency and stability of sunflower crop production at national scale
Casadebaig, P.; Gauffreteau, A.; Landre, A.; Langlade, N.; Mestries, E.; Sarron, J.; Trepos, R.; Vincourt, P.; Debaeke, P.
10.1101/2020.09.21.306076 — plant biology — Posted on 2022-03-17
1996 Analysis of 8000 proteins and reduced carry over significantly increase the throughput of single-shot proteomics
Stejskal, K.; Op de Beeck, J.; Matzinger, M.; Duernberger, G.; Boychenko, O.; Jacobs, P.; Mechtler, K.
10.1101/2021.11.28.470272 — biochemistry — Posted on 2022-03-17
1997 Evolution of transposable element-derived enhancer activity
Du, A. Y.; Zhuo, X.; Sundaram, V.; Jensen, N. O.; Chaudhari, H. G.; Saccone, N. L.; Cohen, B. A.; Wang, T.
10.1101/2022.03.16.483999 — genetics — Posted on 2022-03-17
2000 Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma
Ou, Z.; Lin, S.; Qiu, J.; Ding, W.; Ren, P.; Chen, D.; Wang, J.; Tong, Y.; Wu, D.; Chen, A.; Deng, Y.; Cheng, M.; Peng, T.; Lu, H.; Yang, H.; Wang, J.; Jin, X.; Ma, D.; Xu, X.; Wang, Y.; Li, J.; Wu, P.
10.1101/2021.12.23.473944 — cancer biology — Posted on 2022-03-17
2005 Invasion genetics of the longhorn crazy ant: the global expansion of a double-clonal reproduction system
Tseng, S.-P.; Darras, H.; Hsu, P.-W.; Yoshimura, T.; Lee, C.-Y.; Wetterer, J.; Keller, L.; Yang, C.-C. S.
10.1101/2022.03.17.484689 — evolutionary biology — Posted on 2022-03-17
2006 Medial septum glutamate neurons are essential for spatial goal-directed memory
Bott, J.-B.; Robinson, J.; Manseau, F.; Gauthier-Lafreniere, E.; Williams, S.
10.1101/2022.03.16.484657 — neuroscience — Posted on 2022-03-17
2007 Chimpanzees organize their social relationships like humans
Escribano, D.; Doldan-Martelli, V.; Cronin, K. A.; Haun, D. B. M.; van Leeuwen, E. J. C.; Cuesta, J. A.; Sanchez, A.
10.1101/2022.03.16.484664 — animal behavior and cognition — Posted on 2022-03-17
2011 Hypothalamic-pituitary-adrenal axis dysfunction worsens epilepsy outcomes and increases SUDEP risk
Basu, T.; Antonoudiou, P.; Weiss, G.; Friedman, D.; Laze, J.; Devinsky, O.; Maguire, J.
10.1101/2022.03.15.484525 — neuroscience — Posted on 2022-03-17
2012 Multimodal spatiotemporal phenotyping of human organoid development
Wahle, P.; Brancati, G.; Harmel, C.; He, Z.; Gut, G.; Santos, A.; Yu, Q.; Noser, P.; Fleck, J. S.; Gjeta, B.; Pavlinic, D.; Picelli, S.; Hess, M.; Schmidt, G.; Lummen, T.; Hou, Y.; Galliker, P.; Renner, M.; Pelkmans, L.; Treutlein, B.; Camp, J. G.
10.1101/2022.03.16.484396 — systems biology — Posted on 2022-03-17
2014 DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
Baldwin, L. A.; Bartonicek, N.; Yang, J.; Wu, S. Z.; Deng, N.; Roden, D. L.; Chan, C.-L.; Al-Eryani, G.; Zanker, D. J.; Parker, B. S.; Swarbrick, A.; Junankar, S.
10.1101/2021.01.11.426174 — cancer biology — Posted on 2022-03-17
2017 A retinal circuit that vetoes optokinetic responses to fast visual motion
Mani, A.; Yang, X.; Zhao, T.; Leyrer, M. L.; Schreck, D.; Berson, D. M.
10.1101/2021.10.31.466688 — neuroscience — Posted on 2022-03-17
2018 The language network supports both lexical access and sentence generation during language production
Hu, J.; Small, H.; Kean, H.; Takahashi, A.; Zekelman, L.; Kleinman, D.; Ryan, E.; Ferreira, V.; Fedorenko, E.
10.1101/2021.09.10.459596 — neuroscience — Posted on 2022-03-17
2019 Rapid Biomarker Screening of Alzheimer's Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy
Wang, Z.; Ye, J.; Zhang, K.; Ding, L.; Granzier-Nakajima, T.; Ranasinghe, J.; Xue, Y.; Sharma, S.; Biase, I.; Terrones, M.; Choi, S. H.; Ran, C.; Tanzi, R. E.; Huang, S. X.; Zhang, C. M.; Huang, S.
10.1101/2021.06.03.446929 — neuroscience — Posted on 2022-03-17
2023 The DNA methylation landscape of the human oxytocin receptor gene (OXTR): Recommendations for future research
Mueller, S.; Sicorello, M.; Moser, D. A.; Frach, L.; Limberg, A.; Gumpp, A. M.; Ramo-Fernandez, L.; Koehler-Dauner, F.; Fegert, J. M.; Waller, C.; Kumsta, R.; Kolassa, I.-T.
10.1101/2022.03.16.484588 — molecular biology — Posted on 2022-03-16
2027 Phase separated ribosome nascent chain complexes paused in translation are capable to continue expression of proteins playing role in genotoxic stress response upon DNA damage
Nemeth-Szatmari, O.; Gyorkei, A.; Varga, D.; H.Kovacs, B. B.; Igaz, N.; Nemet, K.; Bagi, N.; Nagy-Miko, B.; Balogh, D.; Razga, Z.; Erdelyi, M.; Papp, B.; Kiricsi, M.; Blastyak, A.; Collart, M.; M. Boros, I.; Villanyi, Z.
10.1101/2022.03.16.484567 — molecular biology — Posted on 2022-03-16
2028 Chemical and genetic screens identify new regulators of tetracycline-inducible gene expression system in mammalian cells
Colicchia, V.; Haggblad, M.; Sirozh, O.; Porebski, B.; Balan, M.; Lidemalm, L.; Carreras-Puigvert, J.; Huhn, D.; Fernandez-Capetillo, O.
10.1101/2022.03.16.484587 — molecular biology — Posted on 2022-03-16
2031 Strain-specific alterations in gut microbiome and host immune responses elicited by Bifidobacterium pseudolongum
Ma, B.; Gavzy, S. J.; Saxena, V.; Song, Y.; Piao, W.; Lwin, H. W.; Lakhan, R.; Lyyathurai, J.; Li, L.; France, M.; Paluskievicz, C.; WillsonShirkey, M.; Hittle, L.; Munawwar, A.; Mongodin, E. F.; Bromberg, J. S.
10.1101/2022.03.16.484607 — microbiology — Posted on 2022-03-16
2032 PeroxiHUB: a modular cell-free biosensing platform using H2O2 as signal integrator
Soudier, P.; Duigou, T.; Voyvodic, P. L.; Zuniga, A.; Bazi-Kabbaj, K.; Kushwaha, M.; Bonnet, J.; Faulon, J.-L.
10.1101/2022.03.16.484621 — synthetic biology — Posted on 2022-03-16
2033 Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses
Monticone, G.; Csibi, F.; Leit, S.; Ciccone, D.; Champhekar, A.; Austin, J. E.; Ucar, D. A.; Hossain, F.; Huang, Z.; Ibba, S. V.; Boulares, A. H.; Carpino, N.; Majumder, S.; Xu, K.; Osborne, B. A.; Loh, C.; Miele, L.
10.1101/2022.03.15.484378 — cancer biology — Posted on 2022-03-16
2034 Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
Pekkarinen, M.; Nordfors, K.; Uusi-Makela, J.; Kytola, V.; Rauhala, M.; Urhonen, H.; Hayrynen, S.; Afyounian, E.; Yli-Harja, O.; Zhang, W.; Helen, P.; Lohi, O.; Haapasalo, H.; Haapasalo, J.; Nykter, M.; Kesseli, J.; Granberg, K. J.
10.1101/2022.03.14.483566 — cancer biology — Posted on 2022-03-16
2036 A single-cell clusters similarity measure for different batches, datasets, and samples
Gonzalez-Velasco, O.; Sanchez-Luis, E.; De La Rosa, E.; Sanchez-Santos, J. M.; De Las Rivas, J.
10.1101/2022.03.14.483731 — bioinformatics — Posted on 2022-03-16
2037 In depth exploration of the alternative proteome of Drosophila melanogaster
Fabre, B.; Choteau, S. A.; Duboe, C.; Pichereaux, C.; Montigny, A.; Korona, D.; Deery, M. J.; Camus, M.; Brun, C.; Burlet-Schiltz, O.; Russell, S.; Jean-Philippe, C.; Lilley, K. S.; Plaza, S.
10.1101/2022.03.16.484563 — biochemistry — Posted on 2022-03-16
2039 Plasmid stability in fluctuating environments:population genetics of multi-copy plasmids
Miro Pina, V.; Hernandez-Beltran, J. C. R.; Siri-Jegousse, A.; Palau, S.; Pena-Miller, R.; Gonzalez-Casanova, A.
10.1101/2022.03.15.484385 — evolutionary biology — Posted on 2022-03-16
2040 Hibernation shows no apparent effect on germline mutation rates in grizzly bears
Wang, R. J.; Pena-Garcia, Y.; Bibby, M.; Raveendran, M.; Harris, R. A.; Jansen, H. T.; Robbins, C. T.; Rogers, J.; Kelley, J. L.; Hahn, M. W.
10.1101/2022.03.15.481369 — evolutionary biology — Posted on 2022-03-16
2041 ANTARCTIC FUNGI: A BIO-SOURCE ALTERNATIVE TO PRODUCE POLYUNSATURATED FATTY ACIDS (PUFAs)
De Rossi, P.; Ambrico, A.; Del Fiore, A.; Trupo, M.; Blasi, L.; Beccaccioli, M.; Faino, L.; Ceci, A.; Maggi, O.; Persiani, A. M.; Reverberi, M.
10.1101/2022.03.14.484320 — ecology — Posted on 2022-03-16
2042 Zika virus NS4A hijacks host ANKLE2 to promote viral replication
Fishburn, A. T.; Hoang, V.; Lopez, N. J.; Shiu, T. N.; Haggard Arce, S. T.; Khan, S. S.; Shah, P. S.
10.1101/2022.03.15.484510 — molecular biology — Posted on 2022-03-16
2044 Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites
Mejia, A. G.; Arnold, K.; Baer, J.; Sing, K. D.; Scheier, T. C.; Brugger, S. D.; Zinkernagel, A. S.; Sinues, P.
10.1101/2022.03.16.484604 — microbiology — Posted on 2022-03-16
2045 Tales of Two α-Carboxysomes: the Structure and Assembly of Cargo Rubisco
Ni, T.; Sun, Y.; Seaton-Burn, W.; Al-Hazeem, M. M.; Zhu, Y.; Yu, X.; Liu, L.-N.; zhang, p.
10.1101/2022.03.15.484529 — microbiology — Posted on 2022-03-16
2047 Dynamic model of bovine brucellosis to investigate control strategies in endemic settings
Holt, H. R.; Walker, M.; Beavais, W.; Kaur, P.; Bedi, J. S.; Mangtani, P.; Sharma, N. S.; Gill, J. P. S.; Godfroid, J.; McGiven, J. A.; Guitian, J.
10.1101/2022.03.14.483550 — microbiology — Posted on 2022-03-16
2051 Molecular Dynamics simulation of TDP-43 RRM in the presence and absence of RNA
Scott, D.; Mowrey, D.; Nagarajan, K.; Francois-Moutal, L.; Nair, A.; Khanna, M.
10.1101/2022.03.15.484514 — biophysics — Posted on 2022-03-16
2053 MePMe-seq: Antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing
Hartstock, K.; Ovcharenko, A.; Kueck, N. A.; Spacek, P.; Cornelissen, N. V.; Huewel, S.; Dieterich, C.; Rentmeister, A.
10.1101/2022.03.16.484494 — biochemistry — Posted on 2022-03-16
2055 Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines
Bowen, J. E.; Sprouse, K. R.; Walls, A. C.; Mazzitelli, I. G.; Logue, J. K.; Franko, N. M.; Ahmed, K.; Shariq, A.; Cameroni, E.; Gori, A.; Bori, A.; Posavad, C. M.; Dan, J. M.; Zhang, Z.; Weiskopf, D.; Sette, A.; Crotty, S.; Talat Iqbal, N.; Corti, D.; Geffner, J.; Grifantini, R.; Chu, H. Y.; Veesler, D.
10.1101/2022.03.15.484542 — immunology — Posted on 2022-03-16
2058 Nitrogen and phosphorus deficiencies alter primary and secondary metabolites of soybean roots
Nezamivand-Chegini, M.; Metzger, S.; Moghadam, A.; Tahmasebi, A.; Koprivova, A.; Eshghi, S.; Mohammadi-Dehchesmeh, M.; Kopriva, S.; Niazi, A.; Ebrahimie, E.
10.1101/2022.03.14.484309 — plant biology — Posted on 2022-03-16
2059 Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents
Hochuli, J. E.; Jain, S.; Melo-Filho, C.; Sessions, Z. L.; Bobrowski, T.; Choe, J.; Zheng, J.; Eastman, R.; Talley, D. C.; Rai, G.; Simeonov, A.; Tropsha, A.; Muratov, E.; Baljinnyam, B.; Zakharov, A. V.
10.1101/2022.03.15.484484 — bioinformatics — Posted on 2022-03-16
2060 Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2
Jana, I. D.; Bhttacharya, P.; Mayilsamy, K.; Banerjee, S.; Bhattacharje, G.; Das, S.; Aditya, S.; Ghosh, A.; McGill, A. R.; Srikrishnan, S.; Das, A. K.; Basak, A.; Mohapatra, S. S.; Chandran, B.; Bhimsaria, D.; Mohapatra, S.; Roy, A.; Mondal, A.
10.1101/2022.03.16.484554 — biochemistry — Posted on 2022-03-16
2062 A conserved immune trajectory of recovery in hospitalized COVID-19 patients
Okholm, T. L. H.; Burnett, C. E.; Tenvooren, I.; Marquez, D. M.; Tamaki, S.; Sandoval, P. M.; The UCSF COMET Consortium, ; Calfee, C. S.; Hendrickson, C. M.; Kangelaris, K. N.; Langelier, C. R.; Krummel, M. F.; Woodruff, P. G.; Erle, D. J.; Ansel, K. M.; Spitzer, M. H.
10.1101/2022.03.15.484467 — immunology — Posted on 2022-03-16
2063 Dual STDP processes at Purkinje cells contribute to distinct improvements in accuracy and vigor of saccadic eye movements.
Fruzzetti, L.; Kalidindi, H. T.; Antonietti, A.; Alessandro, C.; Geminiani, A.; Casellato, C.; Falotico, E.; D'Angelo, E. U.
10.1101/2022.03.14.483471 — neuroscience — Posted on 2022-03-16
2065 Age-dependent lipid droplet-rich microglia worsen stroke outcome in old mice
Arbaizar-Rovirosa, M.; Gallizioli, M.; Pedragosa, J.; Lozano, J. J.; Casal, C.; Pol, A.; Planas, A. M.
10.1101/2022.03.14.484305 — neuroscience — Posted on 2022-03-16
2066 Predictable and stable epimutations induced during clonal propagation with embryonic transcription factors
Wibowo, A.; Antunez-Sanchez, J.; Dawson, A.; Price, J.; Meehan, C.; Wrightsman, T.; Collenberg, M.; Berzukov, I.; Becker, C.; Benhamed, M.; Weigel, D.; Gutierrez-Marcos, J.
10.1101/2022.03.15.484412 — plant biology — Posted on 2022-03-16
2068 Learning deep representations of enzyme thermal adaptation
Li, G.; Buric, F.; Zrimec, J.; Viknander, S.; Nielsen, J.; Zelezniak, A.; Engqvist, M. K.
10.1101/2022.03.14.484272 — bioinformatics — Posted on 2022-03-16
2070 MiXcan: a Framework for Cell-Type-Specific Transcriptome-Wide Association Studies with an Application to Breast Cancer
Song, X.; Ji, J.; Rothstein, J. H.; Alexeeff, S. E.; Sakoda, L. C.; Sistig, A.; Achacoso, N.; Jorgenson, E.; Whittemore, A. S.; Klein, R. J.; Habel, L. A.; Wang, P.; Sieh, W.
10.1101/2022.03.15.484509 — bioinformatics — Posted on 2022-03-16
2071 Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins
Wojciechowski, J. W.; Tekoglu, E.; Gasior-Glogowska, M.; Coustou, V.; Szulc, N.; Szefczyk, M.; Kopaczynska, M.; Saupe, S. J.; Dyrka, W.
10.1101/2022.03.16.484565 — bioinformatics — Posted on 2022-03-16
2072 MR-DoC2: bidirectional causal modeling with instrumental variables and data from relatives
Araujo, L. F.; Singh, M.; Zhou, Y. D.; Vinh, P.; Verhulst, B.; Dolan, C. V.; Neale, M. C.
10.1101/2022.03.14.484271 — genetics — Posted on 2022-03-16
2075 Plakoglobin is a mechanoresponsive regulator of naïve pluripotency
Kohler, T. N.; De Jonghe, J.; Ellermann, A. L.; Yanagida, A.; Herger, M.; Slatery, E. M.; Fischer, K.; Mulas, C.; Winkel, A.; Ross, C.; Bergmann, S.; Franze, K.; Chalut, K.; Nichols, J.; Boroviak, T. E.; Hollfelder, F.
10.1101/2022.03.13.484158 — developmental biology — Posted on 2022-03-16
2076 Individualized Gaussian Process-based Prediction of Memory Performance and Biomarker Status in Ageing and Alzheimer's disease
Nemali, A.; Vockert, N.; Berron, D.; Maas, A.; Yakupov, R.; Peters, O.; Gref, D.; Cosma, N.; Preis, L.; Priller, J.; Spruth, E. J.; Altenstein, S.; Lohse, A.; Fliessbach, K.; Kimmich, O.; Vogt, I.; Wiltfang, J.; Hansen, N.; Bartels, C.; H. Schott, B.; Maier, F.; Meiberth, D.; Glanz, W.; Incesoy, E.; Butryn, M.; Buerger, K.; Janowitz, D.; Ewers, M.; Perneczky, R.; Rauchmann, B.-S.; Burow, L.; Teipel, S.; Kilimann, I.; Göerss, D.; Dyrba, M.; Laske, C.; Munk, M. H.; Sanzenbacher, C.; Müller, S.; Spottke, A.; Roy, N.; Heneka, M. T.; Brosseron, F.; Röske, S.; Dobisch, L.; Ramirez, A.; Ewers, M.;
10.1101/2022.03.14.484226 — neuroscience — Posted on 2022-03-16
2077 Increases in vein length compensate for leaf area lost to lobing in grapevine
Migicovsky, Z.; Swift, J. F.; Helget, Z.; Klein, L. L.; Ly, A.; Maimaitiyiming, M.; Woodhouse, K.; Fennell, A.; Kwasniewski, M.; Miller, A. J.; Cousins, P.; Chitwood, D. H.
10.1101/2022.03.15.484490 — plant biology — Posted on 2022-03-16
2078 Epistatic Modifiers Influence the Expression of Continual Flowering in Strawberry
Cockerton, H.; Nellist, C.; Hytonen, T.; Litthauer, S.; Hopson, K.; Whitehouse, A.; Sobczyk, M. K.; Harrison, R.
10.1101/2022.03.15.484381 — plant biology — Posted on 2022-03-16
2079 Remorin proteins serve as membrane topology scaffolds in plants
Su, C.; Rodriguez-Franco, M.; Lace, B.; Nebel, N.; Hernandez-Ryes, C.; Liang, P.; Schulze, E.; Popp, C.; Keller, J.; Libourel, C.; Fischer, A.; Gabor, K.; Mymrikov, E.; Gross, N.; Mark, E.; Hunte, C.; Weber, W.; Wendler, P.; Stanislas, T.; Delaux, P.-M.; Einsle, O.; Ott, T.
10.1101/2022.03.15.484384 — plant biology — Posted on 2022-03-16
2084 High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitors
Mazzarella, L.; Falvo, P.; Adinolfi, M.; Tini, G.; Gatti, E.; Piccioni, R.; Bonetti, E.; Dorronzoro, E. G.; Bodini, M.; Gallo, B.; Orecchioni, S.; Duso, B. A.; Ronchini, C.; Sanarico, A. G.; Pallavi, R.; Roerink, S.; Bertolini, F.; Alcalay, M.; Dellino, G. I.; Pelicci, P. G.
10.1101/2022.03.14.483944 — cancer biology — Posted on 2022-03-16
2085 Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies
Khan, A. O.; Colombo, M.; Reyat, J. S.; Wang, G.; Rodriguez-Romera, A.; Wen, W. X.; Murphy, L.; Grygielska, B.; Mahony, C.; Stone, A.; Croft, A.; Bassett, D. C.; Pooligasundarampillai, G.; Roy, A.; Gooding, S.; Rayes, J.; Machlus, K.; Psaila, B.
10.1101/2022.03.14.483815 — cancer biology — Posted on 2022-03-16
2086 Hyperglycemic O-GlcNAc transferase activity drives cancer stem cell induction in TNBC
Ayodeji, S.; Bao, B.; Teslow, E. A.; Polin, L. A.; Dyson, G.; Bollig-Fischer, A.; Fehl, C.
10.1101/2022.03.14.484003 — cancer biology — Posted on 2022-03-16
2088 Identification of m6A and m5C RNA modifications at single-molecule resolution from Nanopore sequencing
Acera Mateos, P.; Sethi, A. J.; Guarnacci, M.; Ravindran, A.; Srivastava, A.; Xu, J.; Woodward, K.; Hamilton, W.; Gao, J.; Starrs, L. M.; Hayashi, R.; Burgio, G.; Wickramasinghe, V. O.; Dehorter, N.; Preiss, T.; Shirokikh, N. E.; Eyras, E.
10.1101/2022.03.14.484124 — bioinformatics — Posted on 2022-03-16
2092 CovRadar: Continuously tracking and filtering SARS-CoV-2 mutations for molecular surveillance
Wittig, A.; Miranda, F.; Hölzer, M.; Altenburg, T.; Bartoszewicz, J. M.; Beyvers, S.; Dieckmann, M. A.; Genske, U.; Giese, S. H.; Nowicka, M.; Richard, H.; Schiebenhoefer, H.; Schmachtenberg, A.-J.; Sieben, P.; Tang, M.; Tembrockhaus, J.; Renard, B. Y.; Fuchs, S.
10.1101/2021.02.03.429146 — bioinformatics — Posted on 2022-03-16
2098 Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution
Ainciburu, M.; Ezponda, T.; Berastegui, N.; Alfonso-Pierola, A.; Vilas-Zornoza, A.; San Martin-Uriz, P.; Alignani, D.; Lamo de Espinosa, J.; San Julian, M.; Jimenez, T.; Lopez, F.; Muntion, S.; Sanchez-Guijo, F.; Molero, A.; Montoro, J.; Serrano, G.; Diaz-Mazkiaran, A.; Lasaga, M.; Gomez-Cabrero, D.; Diez-Campelo, M.; Valcarcel, D.; Hernaez, M.; Romero, J. P.; Prosper, F.
10.1101/2021.07.30.454542 — genomics — Posted on 2022-03-16
2099 Genetic affinities and adaptation of the South West coast populations of India
Kumar, L.; Chowdhari, A.; Sequeira, J.; Mustak, M. S.; Banerjee, M.; Thangaraj, K.
10.1101/2022.03.14.484270 — genetics — Posted on 2022-03-16
2103 Beetles provide directed dispersal of viable spores of a keystone wood decay fungus
Lunde, L.; Boddy, L.; Sverdrup-Thygeson, A.; Jacobsen, R.; Kauserud, H.; Birkemoe, T.
10.1101/2022.03.14.484227 — ecology — Posted on 2022-03-16
2106 Sharp wave ripples in macaque V1 and V4 are modulated by top-down visual attention
Doostmohammadi, J.; Gieselmann, M. A.; van Kempen, J.; Lashgari, R.; Yoonessi, A.; Thiele, A.
10.1101/2022.03.14.484243 — neuroscience — Posted on 2022-03-16
2109 Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia
Arihisa, W.; Kondo, T.; Yamaguchi, K.; Matsumoto, J.; Nakanishi, H.; Kunii, Y.; Akatsu, H.; Hino, M.; Hashizume, Y.; Sato, S.; Sato, S.; Niwa, S.-I.; Yabe, H.; Sasaki, T.; Shigenobu, S.; Setou, M.
10.1101/2022.03.14.483348 — pathology — Posted on 2022-03-16
2110 Uneven terrain treadmill walking in younger and older adults
Downey, R. J.; Richer, N.; Gupta, R.; Liu, C.; Pliner, E. M.; Roy, A.; Hwang, J.; Clark, D. J.; Hass, C. J.; Manini, T. M.; Seidler, R. D.; Ferris, D. P.
10.1101/2022.03.01.482507 — bioengineering — Posted on 2022-03-16
2111 Resurrected Rubisco suggests uniform carbon isotope signatures over geologic time
Kedzior, M.; Garcia, A. K.; Li, M.; Taton, A.; Adam, Z. R.; Young, J. N.; Kacar, B.
10.1101/2021.05.31.446354 — evolutionary biology — Posted on 2022-03-16
2113 Molecular Crowding Facilitates Bundling of IMPDH Polymers and Cytoophidium Formation
Chang, C.-C.; Peng, M.; Zhong, J.; Zhang, Z.; Keppeke, G. D.; Sung, L.-Y.; Liu, J.-L.
10.1101/2022.03.15.484061 — cell biology — Posted on 2022-03-16
2115 Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria
Gibson, A. J.; Stiens, J.; Passmore, I. J.; Faulkner, V.; Miculob, J.; Willcocks, S.; Coad, M.; Berg, S.; Werling, D.; Wren, B.; Nobeli, I.; Villarreal-Ramos, B.; Kendall, S. L.
10.1101/2022.03.15.484275 — microbiology — Posted on 2022-03-16
2116 CDKL5 deficiency slows synaptic vesicle endocytosis
Kontaxi, C.; Davenport, E. C.; Kind, P. C.; Cousin, M. A.
10.1101/2022.03.15.484308 — neuroscience — Posted on 2022-03-16
2117 Cell size and actin architecture determine force generation in optogenetically activated adherent cells
Andersen, T.; Worthmuller, D.; Probst, D.; Wang, I.; Moreau, P.; Fitzpatrick, V.; Boudou, T.; Schwarz, u.; Balland, m.
10.1101/2022.03.15.484408 — biophysics — Posted on 2022-03-16
2121 A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease
Rustam, S.; Hu, Y.; Mahjour, S. B.; Rendeiro, A. F.; Ravichandran, H.; Randell, S. H.; Richmond, B.; Polosukhin, V.; Kropski, J. A.; Blackwell, T. S.; d'Ovidio, F.; Martinez, F. J.; Elemento, O.; Shaykhiev, R.
10.1101/2022.03.16.484543 — cell biology — Posted on 2022-03-16
2124 Cellular redox metabolism is modulated by the distinct localization of cyclic nucleotide phosphodiesterase 5A isoforms
Cardarelli, S.; Miele, A. E.; Campolo, F.; Massimi, M.; Mancini, P.; Biagioni, S.; Naro, F.; Giorgi, M.; Saliola, M.
10.1101/2022.03.14.484257 — cell biology — Posted on 2022-03-16
2125 CyberSco.Py: open-source software for event-based, conditional microscopy
Chiron, L.; Le Bec, M.; Cordier, C.; Pouzet, S.; Milunov, D.; Banderas, A.; Di Meglio, J.-M.; Sorre, B.; Hersen, P.
10.1101/2022.03.16.484589 — cell biology — Posted on 2022-03-16
2126 FGF10 triggers de novo alveologenesis in a BPD model: impact on the resident mesenchymal niche cells
Taghizadeh, S.; Chao, C.-M.; Guenther, S.; Glaser, L.; Gersmann, L.; Michel, G.; Kraut, S.; Goth, K.; Koepke, J.; Herold, S.; Samakovlis, C.; Weissmann, N.; Aquila, g.; Ricci, F.; Boyer, L.; Erhardt, H.; Minoo, P.; Bellusci, S.; Rivetti, S.
10.1101/2022.03.14.484213 — cell biology — Posted on 2022-03-16
2131 Strain stiffening of the Ndc80 complex
Schwietert, F.; Volkov, V. A.; Huis in 't Veld, P. J.; Dogterom, M.; Musacchio, A.; Kierfeld, J.
10.1101/2022.03.15.484438 — biophysics — Posted on 2022-03-16
2134 Genetic Loci and Metabolic States Associated With Murine Epigenetic Aging
Mozhui, K.; Lu, A.; Li, C. Z.; Haghani, A.; Sandoval-Sierra, J. V.; Wu, Y.; Williams, R. W.; Horvath, S.
10.1101/2021.06.23.449634 — genomics — Posted on 2022-03-16
2135 Identification of fetal liver stromal subsets in spectral cytometry using the parameter autofluorescence
Peixoto, M.; Soares-da-Silva, F.; Schmutz, S.; Mailhe, M.-P.; Novault, S.; Cumano, A.; Ait Mansour, C.
10.1101/2021.09.29.462345 — developmental biology — Posted on 2022-03-16
2136 Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins
Cogo, S.; Tomkins, J. E.; Vavouraki, N.; Giusti, V.; Forcellato, F.; Franchin, C.; Tessari, I.; Arrigoni, G.; Cendron, L.; Manzoni, C.; Civiero, L.; Lewis, P. A.; Greggio, E.
10.1101/2020.09.09.289009 — cell biology — Posted on 2022-03-16
2137 Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts
Schiff, L.; Migliori, B.; Chen, Y.; Carter, D.; Bonilla, C.; Hall, J.; Fan, M.; Tam, E.; Ahadi, S.; Fischbacher, B.; Geraschenko, A.; Hunter, C. J.; Venugopalan, S.; DesMarteau, S.; Narayanaswamy, A.; Jacob, S.; Armstrong, Z.; Ferrarotto, P.; Williams, B.; Buckley-Herd, G.; Hazard, J.; Goldberg, J.; Coram, M.; Otto, R.; Baltz, E. A.; Andres-Martin, L.; Pritchard, O.; Duren-Lubanski, A.; Daigavane, A.; Reggio, K.; NYSCF Global Stem Cell Array Team, ; Nelson, P. C.; Frumkin, M.; Solomon, S. S.; Bauer, L.; Aiyar, R. S.; Schwarzbach, E.; Noggle, S. A.; Monsma, F. J.; Paull, D.; Berndl, M.; Yang,
10.1101/2020.11.13.380576 — cell biology — Posted on 2022-03-16
2141 HippUnfold: Automated hippocampal unfolding, morphometry, and subfield segmentation
DeKraker, J.; Haast, R. A.; Yousif, M. D.; Karat, B.; Kohler, S.; Khan, A. R.
10.1101/2021.12.03.471134 — neuroscience — Posted on 2022-03-16
2143 Organization of cortical and thalamic input to inhibitory neurons in mouse motor cortex
Okoro, S. U.; Goz, R. U.; Njeri, B. W.; Harish, M.; Ruff, C. F.; Ross, S. E.; Gerfen, C. R.; Hooks, B. M.
10.1101/2021.07.08.451716 — neuroscience — Posted on 2022-03-16
2144 Evolution of genome fragility enables microbial division of labor
Colizzi, E. S.; van Dijk, B.; Merks, R. M. H.; Rozen, D. E.; Vroomans, R. M.
10.1101/2021.06.04.447040 — evolutionary biology — Posted on 2022-03-16
2145 Nitrogen fixation in mesoscale eddies of the North Pacific Subtropical Gyre: patterns and mechanisms
Dugenne, M.; Gradoville, M. R.; Church, M. J.; Barone, B.; Wilson, S. T.; Sheyn, U.; Harke, M.; Björkman, K. M.; Hawco, N. J.; Hynes, A. M.; Ribalet, F.; White, A. E.; Karl, D. M.; DeLong, E. F.; Dyhrman, S. T.; Armbrust, E. V.; John, S.; Eppley, J. M.; Harding, K.; Stewart, B.; Cabello, A. M.; Turk-Kubo, K. A.; Caffin, M.; Zehr, J.
10.1101/2021.06.03.446955 — ecology — Posted on 2022-03-16
2146 TRIM28-dependent SUMOylation protects the adult ovary from the testicular pathway
Rossitto, M.; Dejardin, S.; Rands, C. M.; Legras, S.; Migale, R.; Rafiee, M.-R.; Neirijnck, Y.; Pruvost, A.; Nguyen, A. L.; Bossis, G.; Cammas, F. M.; Le Gallic, L.; Wilhelm, D.; Boizet-Bonhoure, B.; Lovell-Badge, R.; Nef, S.; Poulat, F.
10.1101/2021.03.24.436749 — developmental biology — Posted on 2022-03-16
2148 The orphan ligand, Activin C, signals through activin receptor-like kinase 7
Goebel, E. J.; Ongaro, L.; Kappes, E. C.; Belcheva, E.; Castonguay, R.; Kumar, R.; Bernard, D. J.; Thompson, T.
10.1101/2022.03.16.484571 — biochemistry — Posted on 2022-03-16
2151 Genomes of Two Flying Squid Species Provide Novel Sights into Adaptations of Cephalopods to Pelagic Life
Li, M.; Wu, B.; Zhang, P.; Li, Y.; Xu, W.; Wang, K.; Qiu, Q.; Zhang, J.; Li, J.; Zhang, C.; Fan, J.; Feng, C.; Chen, Z.
10.1101/2022.03.14.484290 — genomics — Posted on 2022-03-16
2154 miR319-targeted TCP4/LANCEOLATE directly regulates OVATE and auxin responses to modulate tomato gynoecium patterning and fruit morphology
Carvalho, A.; Vicente, M. H.; Ferigolo, L. F.; Silva, E. M.; Levy, M.; Peres, L.; Sablowski, R.; Schommer, C.; Ori, N.; Nogueira, F. T.
10.1101/2022.03.15.484181 — plant biology — Posted on 2022-03-16
2155 Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits
Patel, R. A.; Musharoff, S. A.; Spence, J. P.; Pimentel, H.; Tcheandjieu, C.; Mostafavi, H.; Sinnott-Armstrong, N.; Clarke, S. L.; Smith, C. J.; VA Million Veteran Program, ; Durda, P. P.; Taylor, K. D.; Tracy, R.; Liu, Y.; Johnson, C. W.; Aguet, F.; Ardlie, K. G.; Gabriel, S.; Smith, J.; Nickerson, D. A.; Rich, S. S.; Rotter, J. I.; Tsao, P. S.; Assimes, T. L.; Pritchard, J. K.
10.1101/2021.12.06.471235 — genetics — Posted on 2022-03-16
2158 Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation
Thompson, A. F.; Blackburn, P. R.; Arons, N. S.; Stevens, S. N.; Babovic-Vuksanovic, D.; Lian, J. B.; Klee, E. W.; Stumpff, J.
10.1101/2021.09.29.462402 — cell biology — Posted on 2022-03-16
2163 Neonate personality affects early-life resource acquisition in a large social mammal
Amin, B.; Jennings, D. J.; Norman, A.; Ryan, A.; Ioannidis, V.; Magee, A.; Haughey, H.-A.; Haigh, A.; Ciuti, S.
10.1101/2022.03.15.484465 — ecology — Posted on 2022-03-16
2165 Oxidative phosphorylation pathway disruption is an alternative pathological mechanism leading to Diamond-Blackfan anemia
Xiao, R.; Zhang, L.; Xin, Z.; Zhu, J.; Zhang, Q.; Chu, S.; Wu, J.; Zhang, L.; Wan, Y.; Chen, X.; Yuan, W.; Zhang, Z.; Zhu, X.; Fang, X.
10.1101/2022.03.14.484221 — cell biology — Posted on 2022-03-16
2166 Parsing the role of NSP1 in SARS-CoV-2 infection
Fisher, T.; Gluck, A.; Narayanan, K.; Kuroda, M.; Nachshon, A.; C Hsu, J.; J Halfmann, P.; Yahalom-Ronen, Y.; Finkel, Y.; Schwartz, M.; Weiss, S.; K Tseng, C.-T.; Israely, T.; Paran, N.; Kawaoka, Y.; Makino, S.; Stern-Ginossar, N.
10.1101/2022.03.14.484208 — microbiology — Posted on 2022-03-16
2168 Tripartite extended amygdala - basal ganglia CRH circuit drives arousal and avoidance behaviour
Chang, S.; Fermani, F.; Lao, C. L.; Huang, L.; Jakovcevski, M.; Di Giaimo, R.; Gagliardi, M.; Menegaz, D.; Hennrich, A. A.; Ziller, M.; Eder, M.; Klein, R.; Cai, N.; Deussing, J. M.
10.1101/2022.03.15.484057 — neuroscience — Posted on 2022-03-16
2169 Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference
De Leon Reyes, N. S.; Sierra Diaz, P. A.; Nogueira Manas, R.; Ruiz-Pino, A.; Nomura, Y.; de Solis, C. A.; Schulkin, J.; Asok, A.; Leroy, F.
10.1101/2022.03.15.484224 — neuroscience — Posted on 2022-03-16
2170 The development of efficient communication in the human connectome.
van Blooijs, D.; van der Aar, J. F.; Huiskamp, G. J. M.; Castegnaro, G.; Demuru, M.; Zweiphenning, W. J. E. M.; van Eijsden, P.; Miller, K. J.; Leijten, F. S. S.; Hermes, D.
10.1101/2022.03.14.484297 — neuroscience — Posted on 2022-03-16
2171 Reciprocal representation of encoded features by cortical excitatory and inhibitory neuronal populations.
Duszkiewicz, A. J.; Skromne Carrasco, S.; Orhan, P.; Brown, E.; Owczarek, E.; Rojas Vite, G.; Wood, E. R.; Peyrache, A.
10.1101/2022.03.14.484357 — neuroscience — Posted on 2022-03-16
2172 Functional architecture of cerebral cortex during naturalistic movie-watching
Rajimehr, R.; Xu, H.; Farahani, A.; Kornblith, S.; Duncan, J.; Desimone, R.
10.1101/2022.03.14.483878 — neuroscience — Posted on 2022-03-16
2173 A modality independent proto-organization of human multisensory areas
Setti, F.; Handjaras, G.; Bottari, D.; Leo, A.; Diano, M.; Bruno, V.; Tinti, C.; Cecchetti, L.; Garbarini, F.; Pietrini, P.; Ricciardi, E.
10.1101/2022.03.14.484231 — neuroscience — Posted on 2022-03-16
2174 STOmicsDB: a database of Spatial Transcriptomic data
Xu, Z.; Wang, W.; Yang, T.; Chen, J.; Huang, Y.; Gould, J.; Du, W.; Yang, F.; Li, L.; Lai, T.; Hua, C.; Hu, S.; Cai, J.; Li, H.; You, L.; Zeng, W.; Wang, B.; Liu, L.; Xu, X.; Chen, F.; Wei, X.
10.1101/2022.03.11.481421 — genomics — Posted on 2022-03-16
2176 Arctic evergreening - encroaching allelopathy in a management blind spot
Tuomi, M. W.; Utsi, T. A.; Yoccoz, N.; Armstrong, C. W.; Gonzalez, V.; Hagen, S. B.; Jonsdottir, I. S.; Pugnaire, F. I.; Shea, K.; Wardle, D. A.; Zielosko, S.; Brathen, K. A.
10.1101/2022.02.28.482210 — ecology — Posted on 2022-03-16
2180 A spatiotemporal complexity architecture of human brain activity
Krohn, S.; von Schwanenflug, N.; Waschke, L.; Romanello, A.; Gell, M.; Garrett, D. D.; Finke, C.
10.1101/2021.06.04.446948 — neuroscience — Posted on 2022-03-16
2182 Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability
Schlesinger, L. S.; Sadee, W.; Cheeseman, I. H.; Papp, A.; Pietrzak, M.; Seweryn, M.; Zhou, X.; Lin, S.; Williams, A. M.; Arnett, E.; Azad, A. K.
10.1101/2022.03.14.484235 — systems biology — Posted on 2022-03-16
2184 Claudin5 protects the peripheral endothelial barrier in an organ and vessel type-specific manner
Richards, M.; Nwadozi, E.; Pal, S.; Martinsson, P.; Kaakinen, M.; Gloger, M.; Sjöberg, E.; Koltowska, K.; Betsholtz, C.; Eklund, L.; Nordling, S.; Claesson-Welsh, L.
10.1101/2022.03.14.484246 — cell biology — Posted on 2022-03-16
2185 Deep learning based feature extraction for prediction and interpretation of sharp- wave ripples
Navas-Olive, A.; Amaducci, R.; Jurado-Parras, M.-T.; Sebastian, E. R.; de la Prida, L. M.
10.1101/2022.03.11.483905 — neuroscience — Posted on 2022-03-16
2186 IReNA: integrated regulatory network analysis of single-cell transcriptomes
jiang, j.; Lyu, P.; Li, J.; Huang, S.; Blackshaw, S.; Qian, J.; Wang, J.
10.1101/2021.11.22.469628 — bioinformatics — Posted on 2022-03-15
2188 Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin
Zhang, L.; Li, L.; Wang, X.; Liu, H.; Zhang, Y.; Xie, T.; Zhang, H.; Li, X.; Peng, T.; Sun, X.; Dai, J.; Liu, J.; Wu, W.; Ye, M.; Tan, W.
10.1101/2021.08.05.455211 — biochemistry — Posted on 2022-03-15
2189 Production of novel biosurfactant by a new yeast species isolated from Prunus mume Sieb. et Zucc.
Kim, J.-S.; Lee, M.; Ki, D.-W.; Kwon, S.-W.; Ko, Y.-J.; Kim, J.-S.; Yun, B.-S.; Kim, S.-J.
10.1101/2022.03.15.484497 — microbiology — Posted on 2022-03-15
2190 Reproducibility problem with a proposed standard method to measure disinfection efficacy
Hilgren, J.; Srikanth, M.; Brutofsky, M.; Mainquist, K.; Prew, P.; King, W.; Jones, R.; Hellickson, L.; Luedtke, J.; Restrepo, K.; Brill, F.; Quinn, P.; The Efficacy Working Group,
10.1101/2022.03.15.484496 — microbiology — Posted on 2022-03-15
2191 The Use and Misuse of Composite Environmental Indices
Fischer, S. M.; Joy, M. K.; Abrahamse, W.; Milfont, T. L.; Petherick, L. M.
10.1101/2022.03.15.484501 — scientific communication and education — Posted on 2022-03-15
2192 Motor Cortex Excitability in Chronic Low Back Pain
Corti, E. J.; Marinovic, W.; Nguyen, A. T.; Gasson, N.; Loftus, A. M.
10.1101/2022.03.13.484179 — neuroscience — Posted on 2022-03-15
2193 Orthogonal synthetases for polyketide precursors
Fricke, R.; Swenson, C. V.; Roe, L. T.; Hamlish, N.; Ad, O.; Smaga, S.; Gee, C. L.; Schepartz, A.
10.1101/2022.02.28.482149 — synthetic biology — Posted on 2022-03-15
2194 GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation
Thapa, D.; Bugga, P.; Mushala, B. A. S.; Manning, J. R.; Stoner, M. W.; McMahon, B.; Zeng, X.; Cantrell, P.; Yates, N.; Xie, B.; Edmunds, L. R.; Jurczak, M. J.; Scott, I.
10.1101/2021.09.07.459319 — physiology — Posted on 2022-03-15
2195 Increased frequencies of IgH locus suicide recombination points on Chronic Lymphocytic Leukemia with low rate of AID related somatic mutations, cMYC overexpression and short telomeres
Al Jamal, I.; Parquet, M.; Boutouil, H.; Guiyedi, K.; Rizzo, D.; Dupont, M.; Boulin, M.; El Hamel, C.; Lerat, J.; Aoufouchi, S.; Al Hamaoui, S.; Makdissy, N.; Feuillard, J.; Gachard, N.; Peron, S.
10.1101/2022.03.06.482661 — cancer biology — Posted on 2022-03-15
2196 How synonymous mutations alter enzyme structure andfunction over long time scales
Jiang, Y.; Neti, S. S.; Sitarik, I.; Pradhan, P.; To, P.; Xia, Y.; Fried, S. D.; Booker, S. J.; O'Brien, E. P.
10.1101/2021.08.18.456802 — biophysics — Posted on 2022-03-15
2197 Predictive Maps in Rats and Humans for Spatial Navigation
de Cothi, W.; Nyberg, N.; Griesbauer, E.-M.; Ghaname, C.; Zisch, F.; Fletcher, L.; Newton, C.; Renaudineau, S.; Bendor, D.; Grieves, R.; Duvelle, E.; Barry, C.; Spiers, H. J.
10.1101/2020.09.26.314815 — animal behavior and cognition — Posted on 2022-03-15
2198 Darting across space and time: Parametric modulators of sex-biased conditioned fear responding
Mitchell, J. R.; Trettel, S. G.; Li, A. J.; Wasielewski, S.; Huckleberry, K. A.; Fanikos, M.; Golden, E.; Laine, M. A.; Shansky, R. M.
10.1101/2021.06.30.450556 — animal behavior and cognition — Posted on 2022-03-15
2199 Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution
Resztak, J. A.; Wei, J.; Zilioli, S.; Sendler, E.; Alazizi, A.; Mair-Meijers, H. E.; Wu, P.; Slatcher, R. B.; Zhou, X.; Luca, F.; Pique-Regi, R.
10.1101/2021.09.30.462672 — genomics — Posted on 2022-03-15
2201 Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing
Henn, D.; Zhao, D.; Chen, K.; Trotsyuk, A.; Bonham, C. A.; Fischer, K. S.; Kehl, T.; Fehlmann, T.; Sivaraj, D.; Greco, A. H.; Moortgat Illouz, S. E.; Padmanabhan, J.; Barrera, J. A.; Kneser, U.; Lenhof, H.-P.; Januszyk, M.; Levi, B.; Keller, A.; Longaker, M. T.; Qi, L. S.; Gurtner, G. C.
10.1101/2022.03.14.484360 — cell biology — Posted on 2022-03-15
2202 Novel Apelin-expressing gCap Endothelial Stem-like Cells Orchestrate Lung Microvascular Repair
Godoy, R. S.; Cook, D. P.; Cober, N. D.; McCourt, E.; Deng, Y.; Wang, L.; Schlosser, K.; Rowe, K.; Stewart, D. J.
10.1101/2021.07.12.452061 — cell biology — Posted on 2022-03-15
2203 Endosomes deliver ceramide phosphoethanolamine with unique acyl chain anchors to the cleavage furrow during male meiotic cytokinesis
Kunduri, G.; Le, S.-H.; Baena, V.; Nagampalli, V.; Harned, A.; Nagashima, K.; Blankenberg, D.; Izumi, Y.; Narayan, K.; Bamba, T.; Acharya, U.; Acharya, J. K.
10.1101/2021.04.27.441622 — cell biology — Posted on 2022-03-15
2205 Effect of SSRI discontinuation on anxiety-like behaviours in mice
Collins, H. M.; Pinacho, R.; Ozdemir, D.; Bannerman, D. M.; Sharp, T.
10.1101/2021.05.29.446266 — neuroscience — Posted on 2022-03-15
2206 A model of egocentric to allocentric understanding in mammalian brains
Uria, B.; Ibarz, B.; Banino, A.; Zambaldi, V.; Kumaran, D.; Hassabis, D.; Barry, C.; Blundell, C.
10.1101/2020.11.11.378141 — neuroscience — Posted on 2022-03-15
2216 R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures
Donlic, A.; Swanson, E. G.; Chiu, L.-Y.; Wicks, S. L.; Umuhire Juru, A.; Cai, Z.; Kassam, K. J.; Laudeman, C.; Sanaba, B.; Sugarman, A.; Han, E.; Tolbert, B. S.; Hargrove, A. E.
10.1101/2022.03.14.484334 — biochemistry — Posted on 2022-03-15
2218 Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci
Stundlova, J.; Kreklova, M.; Luksikova, K.; Volenikova, A.; Pavlica, T.; Altmanova, M.; Reichard, M.; Dalikova, M.; Pelikanova, S.; Marta, A.; Simanovsky, S. A.; Hirman, M.; Jankasek, M.; Dvorak, T.; Bohlen, J.; Rab, P.; Nguyen, P.; Sember, A.
10.1101/2022.03.13.484186 — evolutionary biology — Posted on 2022-03-15
2220 Crumbs complex-directed apical membrane dynamics in epithelial cell ingression
Simoes, S.; Lerchbaumer, G.; Pellikka, M.; Giannatou, P.; Lam, T.; Kim, D.; Yu, J.; ter Stal, D.; Al Kakouni, K.; Fernandez-Gonzalez, R.; Tepass, U.
10.1101/2022.03.13.484184 — developmental biology — Posted on 2022-03-15
2221 Endocytosis is required for access of surface-bound cargo to the flagellar pocket of trypanosomes
Schichler, D.; Spath, E.-M.; Konle, A.; Riegler, S.; Klein, A.; Seleznev, A.; Jung, S.; Wuppermann, T.; Wetterich, N.; Borges, A.; Meyer-Natus, E.; Havlicek, K.; Cabrera, S. P.; Niedermueller, K.; Sajko, S.; Dohn, M.; Malzer, X.; Riemer, E.; Tumurbaatar, T.; Djinovic-Carugo, K.; Dong, G.; Janzen, C. J.; Morriswood, B.
10.1101/2022.03.15.484455 — cell biology — Posted on 2022-03-15
2224 Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation
Sporre, E.; Karlsen, J.; Schriever, k.; Asplund-Samuelsson, J.; Janasch, M.; Kotol, D.; Strandberg, L.; Zeckey, L.; Piazza, I.; Syren, P.-O.; Edfors, F.; Hudson, E. P.
10.1101/2022.03.15.483797 — systems biology — Posted on 2022-03-15
2227 Integrated platform for multi-scale molecular imaging andphenotyping of the human brain
Park, J.; Wang, J.; Guan, W.; Kamentsky, L.; Evans, N. B.; Gjesteby, L.; Pollack, D.; Choi, S. W.; Snyder, M.; Chavez, D.; Tian, Y.; Su-Arcaro, C.; Yun, D. H.; Zhao, C.; Brattain, L.; Frosh, M. P.; Chung, K.
10.1101/2022.03.13.484171 — bioengineering — Posted on 2022-03-15
2228 Expressed therapeutic protein yields are predicted by transiently transfected mammalian cell population
Porosk, L.; Nebogatova, J.; Hark, H. H.; Vunk, B.; Arukuusk, P.; Toots, U.; Toots, M.; Langel, U.; Kurrikoff, K.
10.1101/2022.03.15.484372 — biochemistry — Posted on 2022-03-15
2231 A subpopulation of Talin 1 resides in the nucleus and regulates gene expression
Da Silva, A. J.; Hästbacka, H. S. E.; Puustinen, M. C.; Pessa, J. C.; Goult, B. T.; Jacquemet, G.; Henriksson, E.; Sistonen, L.
10.1101/2022.03.15.484419 — molecular biology — Posted on 2022-03-15
2232 Endogenous IL-10 Contributes to Wound Healing and Regulates Tissue Repair
Short, W. D.; Rae, M.; Lu, T.; Padon, B.; Prajapati, T. J.; Faruk, F.; Olutoye, O. O.; Yu, L.; Bollyky, P.; Keswani, S. G.; Balaji, S.
10.1101/2022.03.15.484452 — molecular biology — Posted on 2022-03-15
2233 On-Ramp: a tool for rapid, multiplexed validation of plasmids using nanopore sequencing
Mumm, C.; Drexel, M. L.; McDonald, T. L.; Diehl, A.; Switzenberg, J. A.; Boyle, A. P.
10.1101/2022.03.15.484480 — molecular biology — Posted on 2022-03-15
2234 Growth inhibition of Akkermansia muciniphila by a secreted pathobiont sialidase
van Muijlwijk, G. H.; Bröring, E.; van Mierlo, G.; Jansen, P. W.; Vermeulen, M.; Aerts, P. C.; van Putten, J. P.; Palm, N. W.; de Zoete, M. R.
10.1101/2022.03.15.484512 — microbiology — Posted on 2022-03-15
2235 Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria
Gibson, A. J.; Stiens, J.; Passmore, I. J.; Faulkner, V.; Miculob, J.; Willcocks, S.; Coad, M.; Berg, S.; Werling, D.; Wren, B.; Nobeli, I.; Villarreal-Ramos, B.; Kendall, S. L.
10.1101/2022.03.15.484275 — microbiology — Posted on 2022-03-15
2236 High resolution reconstruction of a Jumbo bacteriophage infecting capsulated bacteria using hyperbranched tail fibers
Ouyang, R.; Costa, A. R.; Cassidy, C. K.; Otwinowska, A.; Williams, V. C. J.; Latka, A.; Stansfeld, P. J.; Drulis-Kawa, Z. J.; Briers, Y.; Pelt, D. M.; Brouns, S. J. J.; Briegel, A.
10.1101/2022.03.15.484430 — microbiology — Posted on 2022-03-15
2237 Broad-spectrum extracellular antiviral properties of Cucurbiturils
Jones, L. M.; Super, E. H.; Batt, L. J.; Gasbarri, M.; Cheesman, B. T.; Howe, A. M.; Coulston, R.; Jones, S. T.
10.1101/2022.03.15.484424 — microbiology — Posted on 2022-03-15
2240 Dual spatially resolved transcriptomics for SARS-CoV-2 host-pathogen colocalization studies in humans
Sounart, H.; Lazar, E.; Masarapu, Y.; Wu, J.; Varkonyi, T.; Glasz, T.; Kiss, A.; Borgström, E.; Hill, A.; Jurek, A.; Niesnerova, A.; Druid, H.; Bergmann, O.; Giacomello, S.
10.1101/2022.03.14.484288 — genomics — Posted on 2022-03-15
2241 Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation
Singh, A. K.; Wang, R.; Lombardo, K. A.; Praharaj, M.; Bullen, C. K.; Um, P.; Davis, S.; Komm, O.; Illei, P. B.; Ordonez, A. A.; Bahr, M.; Huang, J.; Gupta, A.; Psoter, K. J.; Jain, S. K.; Bivalacqua, T. J.; Yegnasubramanian, S.; Bishai, W.
10.1101/2022.03.15.484018 — immunology — Posted on 2022-03-15
2244 Dynamic and selective engrams emerge with memory consolidation
Tome, D. F.; Zhang, Y.; Aida, T.; Sadeh, S.; Roy, D. S.; Clopath, C.
10.1101/2022.03.13.484167 — neuroscience — Posted on 2022-03-15
2245 APOE ϵ2 vs APOE ϵ4 dosage shows sex-specific links to hippocampus-default network subregion co-variation
Savignac, C.; Villeneuve, S.; Badhwar, A.; Saltoun, K.; Shafighi, K.; Zajner, C.; Sharma, V.; Taliun, S. A. G.; Farhan, S.; Poirier, J.; Bzdok, D.
10.1101/2022.03.15.484482 — neuroscience — Posted on 2022-03-15
2246 Motor Cortex Excitability in Chronic Low Back Pain
Corti, E. J.; Marinovic, W.; Nguyen, A. T.; Gasson, N.; Loftus, A. M.
10.1101/2022.03.13.484179 — neuroscience — Posted on 2022-03-15
2248 Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters
Rissmann, M.; Noack, D.; van Riel, D.; Schmitz, K. S.; de Vries, R. D.; van Run, P.; Lamers, M. M.; GeurtsvanKessel, C.; Koopmans, M.; Fouchier, R.; Kuiken, T.; Haagmans, B.; Rockx, B.
10.1101/2022.03.15.484448 — microbiology — Posted on 2022-03-15
2249 Neutrophils initiate the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters
Bourgon, C.; Saint-Albin-Deliot, A.; Ando-Grard, O.; Da-Costa, B.; Domain, R.; Korkmaz, B.; Klonjkowski, B.; Lepoder, S.; Meunier, N.
10.1101/2022.03.15.484439 — immunology — Posted on 2022-03-15
2251 Large-scale comparison of immunoassay- and aptamer-based plasma proteomics through genetics and disease
Hjorleifsson Eldjarn, G.; Ferkingstad, E.; Lund, S. H.; Helgason, H.; Magnusson, O. T.; Halldorsson, B. V.; Olason, P. I.; Zink, F.; Gudjonsson, S. A.; Sveinbjornsson, G.; Magnusson, M. I.; Helgason, A.; Oddsson, A.; Halldorsson, G. H.; Magnusson, M. K.; Saevarsdottir, S.; Eiriksdottir, T.; Masson, G.; Stefansson, H.; Jonsdottir, I.; Holm, H.; Rafnar, T.; Melsted, P.; Saemundsdottir, J.; Norddahl, G. L.; Thorleifsson, G.; Ulfarsson, M.; Gudbjartsson, D. F.; Thorsteinsdottir, U.; Sulem, P.; Stefansson, K.
10.1101/2022.02.18.481034 — genomics — Posted on 2022-03-15
2253 Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.
Wing, P. A.; Prange-Barczynska, M.; Cross, A.; Crotta, S.; Orbegozo Rubio, C.; Cheng, X.; Harris, J. M.; Zhuang, X.; Johnson, R. L.; Ryan, K. A.; Hall, Y.; Carroll, M. W.; Issa, F.; Balfe, P.; Wack, A.; Bishop, T.; Salguero, F. J.; McKeating, J. A.
10.1101/2022.03.15.484379 — microbiology — Posted on 2022-03-15
2256 Flotillin-2 regulates EGFR activation, degradation, and cancer growth
Wisniewski, D. J.; Liyasova, M. S.; Korrapati, S.; Zhang, X.; Gilbert, S. F.; Catalano, A.; Voeller, D.; Guha, U. J.; Porat-Shliom, N.; Annunziata, C.; Lipkowitz, S.
10.1101/2022.03.11.483779 — cancer biology — Posted on 2022-03-15
2258 Mutational footprint of platinum chemotherapy in a secondary thyroid cancer
Schiantarelli, J.; Pappa, T.; Conway, J.; Crowdis, J.; Reardon, B.; Dietlein, F.; Huang, J.; Stanizzi, D.; Carey, E.; Bosma-Moody, A.; Imamovic, A.; Han, S.; Camp, S.; Kofman, E.; Shannon, E.; Barletta, J.; He, M. X.; Liu, D.; Park, J.; Lorch, J.; Van Allen, E.
10.1101/2022.03.14.484002 — genomics — Posted on 2022-03-15
2263 Tau forms dynamic hot spots that are resistant to microtubule perturbations and cholesterol depletion
Padmanabhan, P.; Kneynsberg, A.; Gonzalez, E. C.; Amor, R.; Sibarita, J.-B.; Götz, J.
10.1101/2022.02.04.479198 — neuroscience — Posted on 2022-03-15
2264 SALARECON connects the Atlantic salmon genome to growth and feed efficiency
Zakhartsev, M.; Rotnes, F.; Gulla, M.; Oyas, O.; van Dam, J. C. J.; Suarez-Diez, M.; Grammes, F.; Hafthorsson, R. A.; van Helvoirt, W.; Koehorst, J. J.; Schaap, P. J.; Jin, Y.; Mydland, L. T.; Gjuvsland, A. B.; Sandve, S. R.; Martins dos Santos, V. A. .P.; Vik, J. O.
10.1101/2021.06.03.446971 — systems biology — Posted on 2022-03-15
2266 A Microengineered Brain-Chip to Model Neuroinflammation in Humans
Pediaditakis, I.; Kodella, K. R.; Manatakis, D. V.; Le, C. Y.; Barthakur, S.; Sorets, A.; Gravanis, A.; Ewart, L.; Rubin, L. L.; Manolakos, E. S.; Hinojosa, C. D.; Karalis, K.
10.1101/2022.03.11.484005 — bioengineering — Posted on 2022-03-15
2267 The oxytocin system regulates tearing
Nakamura, S.; Toshihiro, I.; Jin, K.; Shibuya, M.; Sakaguchi, H.; Izumiseki, F.; Tanaka, K. F.; Mimura, M.; Nishimori, K.; Kambara, N.; Hirayama, N.; Kamimura, I.; Nomoto, K.; Mogi, K.; Kikusui, T.; Mukai, Y.; Yamanaka, A.; Tsubota, K.
10.1101/2022.03.08.483433 — animal behavior and cognition — Posted on 2022-03-15
2270 Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies
Leonard, A. S.; Crysnanto, D.; Fang, Z.-h.; Heaton, M. P.; Vander Ley, B. L.; Herrera, C.; Bollwein, H.; Bickhart, D. M.; Kuhn, K. L.; Smith, T. P. L.; Rosen, B. D.; Pausch, H.
10.1101/2021.11.02.466900 — genomics — Posted on 2022-03-15
2273 Individual neurophysiological signatures of spontaneous rhythm processing
Criscuolo, A.; Schwartze, M.; Henry, M. J.; Obermeier, C.; Kotz, S. A.
10.1101/2022.03.14.484286 — neuroscience — Posted on 2022-03-15
2276 CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis
Mohanty, S.; Mohapatra, P.; Shriwas, O.; Priyadarshini, M.; Ansari, S. A.; Priyadarsini, S.; Rath, R.; Sultania, M.; Das Majumdar, S. K.; Dash, R.
10.1101/2021.08.19.456939 — cancer biology — Posted on 2022-03-15
2279 An integrated single-cell atlas of the skeleton from development through adulthood
Herpelinck, T.; Ory, L.; Nasello, G.; Barzegari, M.; Bolander, J.; Luyten, F. P.; Tylzanowski, P.; Geris, L.
10.1101/2022.03.14.484345 — bioinformatics — Posted on 2022-03-15
2280 Whole-genome resequencing reveals the population structure, genomic diversity, and demographic history of American chestnut (Castanea dentata)
Sandercock, A. M.; Westbrook, J. W.; Zhang, Q.; Johnson, H. A.; Saielli, T. M.; Scrivani, J. A.; Fitzsimmons, S. F.; Collins, K.; Schmutz, J.; Grimwood, J.; Holliday, J. A.
10.1101/2022.02.11.480151 — genomics — Posted on 2022-03-15
2281 A Genetic History of Continuity and Mobility in the Iron Age Central Mediterranean
Moots, H. M.; Antonio, M. L.; Sawyer, S.; Spence, J. P.; Oberreiter, V.; Weiss, C. L.; Lucci, M.; Cherifi, Y. M. S.; La Pastina, F.; Genchi, F.; Praxmarer, E.; Zagorc, B.; Cheronet, O.; Özdogan, K. T.; Demetz, L.; Amrani, S.; Candilio, F.; De Angelis, D.; Gasperetti, G.; Fernandes, D.; Gao, Z.; Fantar, M.; Coppa, A.; Pritchard, J. K.; Pinhasi, R.
10.1101/2022.03.13.483276 — genomics — Posted on 2022-03-15
2282 Antisense oligonucleotide strategies to increase progranulin levels for frontotemporal dementia
Aggarwal, G.; Banerjee, S.; Jones, S. A.; Smith, D. M.; Benchaar, Y.; Belanger, J.; Sevigny, M.; Pavlack, M. D.; Niehoff, M. L.; de Vera, I. M. S.; Petkau, T. L.; Leavitt, B. R.; Ling, K.; Jafar-Nejad, P.; Rigo, F. D.; Morley, J. E.; Farr, S. A.; Dutchak, P. A.; Sephton, C. F.; Nguyen, A. D.
10.1101/2022.01.12.476053 — neuroscience — Posted on 2022-03-15
2289 CRISPR-Cas Controls Cryptic Prophages
Song, S.; Semenova, E.; Severinov, K.; Garcia, L. F.; Benedik, M. J.; Wood, T. K.
10.1101/2021.07.28.454074 — molecular biology — Posted on 2022-03-14
2290 In vitro susceptibility to β-lactam antibiotics and viability of Neisseria gonorrhoeae strains producing plasmid-mediated broad- and extended-spectrum β-lactamases
Kandinov, I. D.; Gryadunov, D. A.; Vinokurova, A. S.; Antonova, O. V.; Kubanov, A. A.; Solomka, V. S.; Shagabieva, J. Z.; Deryabin, D. G.; Shaskolskiy, B. L.
10.1101/2022.03.11.483876 — microbiology — Posted on 2022-03-14
2291 Structural basis for ultrapotent neutralization of human metapneumovirus
Banerjee, A.; Huang, J.; Rush, S.; Murray, J.; Gingerich, A. D.; Royer, F.; Hsieh, C.-L.; Tripp, R. A.; McLellan, J. S.; Mousa, J. J.
10.1101/2022.03.14.484292 — immunology — Posted on 2022-03-14
2292 Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
Krus, K. L.; Strickland, A.; Yamada, Y.; Devault, L.; Schmidt, R. E.; Bloom, A. J.; Milbrandt, J.; DiAntonio, A.
10.1101/2022.03.13.484188 — neuroscience — Posted on 2022-03-14
2293 Multi-timescale biological learning algorithms train spiking neuronal network motor control
Hasegan, D.; Deible, M.; Earl, C.; D'Onofrio, D.; Hazan, H.; Anwar, H.; Neymotin, S. A.
10.1101/2021.11.20.469405 — neuroscience — Posted on 2022-03-14
2295 Validation of a small molecule inhibitor of PDE6D-RAS interaction with potent anti-leukemic effects
Nunes, S. C.; De Vita, S.; Anighoro, A.; Autelitano, F.; Beaumont, E.; Klingbeil, P.; McGuinness, M.; Duvert, B.; Harris, C.; Yang, L.; Pokharel, S. P.; Chen, C.-W.; Ermann, M.; Williams, D. A.; Xu, H.
10.1101/2022.03.14.484294 — cancer biology — Posted on 2022-03-14
2297 Mitochondrial Redox Adaptations Enable Aspartate Synthesis in SDH-deficient Cells
Hart, M. L.; Quon, E.; Vigil, A.-L. B. G.; Engstrom, I. A.; Newsom, O. J.; Davidsen, K.; Hoellerbauer, P.; Carlisle, S. M.; Sullivan, L. B.
10.1101/2022.03.14.484352 — biochemistry — Posted on 2022-03-14
2298 Structural insights into the regulation of acetylation-dependent genome condensation
Ibrahim, Z.; Wang, T.; Destaing, O.; Salvi, N.; Hoghoughi, N.; Rusu, A. D.; Gao, J.; Feletto, L.; Reynoird, N.; Schalch, T.; Zhao, Y.; Blackledge, M.; Khochbin, S.; Panne, D.
10.1101/2022.03.14.484228 — biochemistry — Posted on 2022-03-14
2299 Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis
Costeira, R.; Aduse-Opoku, J.; Vernon, J. J.; Rodriguez-Algarra, F.; Joseph, S.; Devine, D. A.; Marsh, P. D.; Rakyan, V.; Curtis, M. A.; Bell, J. T.
10.1101/2022.03.14.484211 — genomics — Posted on 2022-03-14
2301 Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)
Fuandila, N. N.; Gosselin-Grenet, A.-S.; Tilak, M.-K.; Bergmann, S. M.; Escoubas, J.-M.; Klafack, S.; Lusiastuti, A. M.; Yuhana, M.; Fiston-Lavier, A.-S.; Avarre, J.-C.; Cherif, E.
10.1101/2022.03.10.483410 — genomics — Posted on 2022-03-14
2310 Intratumoral Recall of Childhood Vaccine-Specific CD4+ T cells Coordinates Type I and II Antitumor Immunity
Brown, M. C.; McKay, Z. P.; Yang, Y.; Beasley, G. M.; Ashley, D. M.; Bigner, D. D.; Nair, S. K.; Gromeier, M.
10.1101/2022.03.14.484260 — immunology — Posted on 2022-03-14
2311 Peritoneal M2 macrophage-derived extracellular vesicles as natural multi-target nanotherapeutics to attenuate cytokine storm after severe infections
Liu, J.; Wang, Y.; Liu, S.; Li, L.; Li, L.; Zhou, X.; Wan, M.; Lou, P.; Zhao, M.; Lv, K.; Yuan, Y.; Chen, Y.; Lu, Y.; Cheng, J.
10.1101/2022.03.13.484180 — immunology — Posted on 2022-03-14
2312 The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins
Petkau, G.; Mitchell, T. J.; Chakraborty, K.; Bell, S. E.; DAngeli, V.; Matheson, L.; Turner, D. J.; Saveliev, A.; Gizlenci, O.; Salerno, F.; Katsikis, P. D.; Turner, M.
10.1101/2021.06.03.446738 — immunology — Posted on 2022-03-14
2314 FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data
Fan, C. C.; Palmer, C. E.; Iverson, J.; Pecheva, D.; Frei, O.; Holland, D.; Thompson, W. K.; Hagler, D.; Jernigan, T. L.; Andreassen, O.; Dale, A. M.; Nichols, T.
10.1101/2021.10.27.466202 — neuroscience — Posted on 2022-03-14
2315 Hypoxia-inducible factor 1 signaling drives placental aging and can elicit inflammatory changes in uterine myocytes
Ciampa, E. J.; Flahardy, P.; Srinivasan, H.; Jacobs, C.; Tsai, L.; Karumanchi, S. A.; Parikh, S. M.
10.1101/2022.03.14.483784 — physiology — Posted on 2022-03-14
2316 MONTE enables serial immunopeptidome, ubiquitylome, proteome, phosphoproteome, acetylome analyses of sample-limited tissues
Abelin, J. G.; Bergstrom, E. J.; Taylor, H. B.; Rivera, K. D.; Klaeger, S.; Xu, C.; White, C. J.; Olive, M. E.; Maynard, M.; Kane, M. H.; Rachimi, S.; Mani, D. R.; Gillette, M. A.; Clauser, K. R.; Udeshi, N. D.; Carr, S. A.
10.1101/2021.06.22.449417 — cancer biology — Posted on 2022-03-14
2322 Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats
Le, T. H.; Crouse, W.; Keele, G.; Holl, K.; Seshie, O.; Tschannen, M.; Craddock, A.; Das, S. K.; McDonald, B.; Sharma, N. K.; Chuang Key, C.-C.; Hawkins, G.; Valdar, W.; Mott, R.; Solberg Woods, L. C.
10.1101/2022.03.14.484225 — genetics — Posted on 2022-03-14
2323 Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
Mohammadi, S.; Yang, L.; Herrera-Alvarez, S.; Rodriguez-Ordonez, M. d. P.; Zhang, K.; Storz, J.; Dobler, S.; Crawford, A. J.; Andolfatto, P.
10.1101/2021.11.29.470343 — evolutionary biology — Posted on 2022-03-14
2324 Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis
Sidarala, V.; Zhu, J.; Levi-D'Ancona, E.; Pearson, G. L.; Reck, E. C.; Walker, E. M.; Kaufman, B. A.; Soleimanpour, S. A.
10.1101/2021.01.10.426151 — cell biology — Posted on 2022-03-14
2326 Endosomes deliver ceramide phosphoethanolamine with unique acyl chain anchors to the cleavage furrow during male meiotic cytokinesis
KUNDURI, G.; Le, S.-H.; Baena, V.; Vijaykrishna, N.; Harned, A.; Nagashima, K.; Blankenberg, D.; Yoshihiro, I.; Narayan, K.; Bamba, T.; Acharya, U.; Acharya, J.
10.1101/2022.03.14.484204 — cell biology — Posted on 2022-03-14
2328 Oxidative phosphorylation pathway disruption is an alternative pathological mechanism leading to Diamond-Blackfan anemia
Xiao, R.; Zhang, L.; Xin, Z.; Zhu, J.; Zhang, Q.; Chu, S.; Wu, J.; Zhang, L.; Wan, Y.; Chen, X.; Yuan, W.; Zhang, Z.; Zhu, X.; Fang, X.
10.1101/2022.03.14.484221 — cell biology — Posted on 2022-03-14
2329 Diffusional variance-determined stochastic translation efficiency
Horvath, A.; Janapala, Y.; D. Hannan, R.; Eyras, E.; Preiss, T.; E. Shirokikh, N.
10.1101/2022.03.13.483370 — molecular biology — Posted on 2022-03-14
2330 STORM-seq Reveals Differentiation Trajectories of Primary Human Fallopian Tube Epithelium
Johnson, B. K.; Rhodes, M.; Wegener, M.; Himadewi, P.; Foy, K.; Schipper, J. L.; Siwicki, R. A.; Rossell, L. L.; Siegwald, E. J.; Chesla, D. W.; Sheridan, R. T. C.; Adams, M.; Shen, H.; Triche, T. J.
10.1101/2022.03.14.484332 — molecular biology — Posted on 2022-03-14
2331 Parsing the role of NSP1 in SARS-CoV-2 infection
Fisher, T.; Gluck, A.; Narayanan, K.; Kuroda, M.; Nachshon, A.; C Hsu, J.; J Halfmann, P.; Yahalom-Ronen, Y.; Finkel, Y.; Schwartz, M.; Weiss, S.; K Tseng, C.-T.; Israely, T.; Paran, N.; Kawaoka, Y.; Makino, S.; Sternn-Ginnosar, N.
10.1101/2022.03.14.484208 — microbiology — Posted on 2022-03-14
2334 Arctic phytoplankton spring bloom diversity across the marginal ice zone in Baffin Bay
Ribeiro, C. G.; dos Santos, A. L.; Trefault, N.; Marie, D.; Lovejoy, C.; Vaulot, D.
10.1101/2022.03.14.484350 — microbiology — Posted on 2022-03-14
2335 Interferon-induced lysosomal membrane permeabilization causes cDC1-deserts in tumors.
Aerakis, E.; Chatzigeorgiou, A.; Kerdidani, D.; Angelidis, I.; Matthaiakaki-Panagiotaki, M.; Malissen, B.; Henri, S.; Tsoumakidou, M.
10.1101/2022.03.14.484263 — immunology — Posted on 2022-03-14
2338 Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions
Boehnke, N.; Straehla, J. P.; Safford, H. C.; Kocak, M.; Rees, M. G.; Ronan, M.; Rosenberg, D.; Adelmann, C. H.; Chivukula, R. R.; Nabar, N.; Berger, A. G.; Lamson, N. G.; Cheah, J. H.; Li, H.; Roth, J. A.; Koehler, A. N.; Hammond, P. T.
10.1101/2021.04.05.438521 — bioengineering — Posted on 2022-03-14
2339 Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape
Hunter, B.; Benoit, M. P. M. H.; Asenjo, A. B.; Doubleday, C.; Trofimova, D.; Sosa, H.; Allingham, J. S.
10.1101/2022.02.28.480783 — biochemistry — Posted on 2022-03-14
2341 Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia
Christie, I. N.; Theparambil, S. M.; Doronin, M.; Hosford, P. S.; Brazhe, A.; Hobbs, A.; Semyanov, A.; Abramov, A. Y.; Angelova, P.; Gourine, A. V.
10.1101/2022.03.13.484128 — neuroscience — Posted on 2022-03-14
2342 Hippocampal theta and episodic memory
Rudoler, J. H.; Herweg, N. A.; Kahana, M. J.
10.1101/2022.03.13.484014 — neuroscience — Posted on 2022-03-14
2344 Novel tuberculosis combination regimens of two and three-months therapy duration
Gumbo, T.; Chapagain, M.; Magombedze, G.; Srivastava, S.; Deshpande, D.; Pasipanodya, J. G.; Gumbo, R.; Dheda, K.; Diacon, A.; Hermann, D. J.; Hanna, D.
10.1101/2022.03.13.484155 — pharmacology and toxicology — Posted on 2022-03-14
2346 Planemo: a command-line toolkit for developing, deploying, and executing scientific data analyses
Bray, S.; Bernt, M.; Soranzo, N.; van den Beek, M.; Batut, B.; Rasche, H.; Cech, M.; Cock, P.; Nekrutenko, A.; Gruning, B.; Chilton, J.
10.1101/2022.03.13.483965 — bioinformatics — Posted on 2022-03-14
2348 kb_DRAM: Annotating and functional profiling of genomes with DRAM in KBase
Shaffer, M.; Borton, M. A.; Bolduc, B.; Ghadermazi, P.; Edirisinghe, J.; Faria, J. P.; Miller, C. S.; Chan, S. H. J.; Sullivan, M. B.; Henry, C. S.; Wrighton, K. C.
10.1101/2022.03.13.484145 — bioinformatics — Posted on 2022-03-14
2351 In vitro engineering of the lung alveolus
Leiby, K. L.; Yuan, Y.; Ng, R.; Raredon, M. S. B.; Adams, T. S.; Baevova, P.; Hirschi, K. K.; Campbell, S. G.; Kaminski, N.; Herzog, E. L.; Niklason, L. E.
10.1101/2022.03.13.484143 — bioengineering — Posted on 2022-03-14
2354 STOmicsDB: a database of Spatial Transcriptomic data
Xu, Z.; Wang, W.; Yang, T.; Chen, J.; Huang, Y.; Gould, J.; Du, W.; Yang, F.; Li, L.; Lai, T.; Hua, C.; Hu, S.; Cai, J.; Li, H.; You, L.; Zeng, W.; Wang, B.; Liu, L.; Xu, X.; Chen, F.; Wei, X.
10.1101/2022.03.11.481421 — genomics — Posted on 2022-03-14
2356 Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission
Ye, C.; Park, J.-G.; Chiem, K.; Dravid, P.; Allue Guardia, A.; Garcia-Vilanova, A.; kapoor, A.; Walter, M. R.; Kobie, J.; Plemper, R. K.; Torrelles, J. B.; Martinez-Sobrido, L.
10.1101/2022.03.13.484172 — microbiology — Posted on 2022-03-14
2357 Antiviral State of CD1c+ cDC contributes to Increased Maturation and Activation of Cytotoxic Natural Killer cells in Sjogrens Syndrome
Sanchez Cerrillo, I.; Calvet Mirabent, M.; Triguero Martinez, A.; Calzada Fraile, D.; Delgado Alfaro, C.; Valdivia, M.; ramirez-Huesca, M.; Vazquez de Luis, E.; Benguria Filippini, A.; Moreno Vellisca, R.; Adrados, M. M.; de la Fuente, H.; Tsukalov, I.; Roy Vallejo, E.; Ramiro, A.; Sanchez Madrid, F.; Dopazo, A.; Gonzalez Alvaro, I.; Castaneda Sanz, S.; Martin-Gayo, E.
10.1101/2022.03.13.484063 — immunology — Posted on 2022-03-14
2360 Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells
Icho, S.; Rujas, E.; Muthuraman, K.; Tam, J.; Liang, H.; Harms, S.; Liao, M.; Falzarano, D.; Julien, J.-P.; Melnyk, R.
10.1101/2022.03.11.484006 — cell biology — Posted on 2022-03-14
2362 A broad and potent neutralization epitope in SARS-related coronaviruses
Yuan, M.; Zhu, X.; He, W.-t.; Zhou, P.; Kaku, C. I.; Capozzola, T.; Zhu, C. Y.; Yu, X.; Liu, H.; Yu, W.; Hua, Y.; Tien, H.; Peng, L.; Song, G.; Cottrell, C.; Schief, W. R.; Nemazee, D.; Walker, L. M.; Andrabi, R.; Burton, D.; Wilson, I. A.
10.1101/2022.03.13.484037 — microbiology — Posted on 2022-03-14
2363 Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events
Ou, J.; Lan, W.; Wu, X.; Zhao, T.; Duan, B.; Yang, P.; Ren, Y.; Quan, L.; Zhao, W.; Seto, D.; Chodosh, J.; Wu, J.; Zhang, Q.
10.1101/2022.03.13.484129 — microbiology — Posted on 2022-03-14
2364 The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes
Greaney, A. J.; Eguia, R. T.; Starr, T. N.; Khan, K.; Franko, N.; Logue, J. K.; Lord, S. M.; Speake, C.; Chu, H. Y.; Sigal, A.; Bloom, J. D.
10.1101/2022.03.12.484088 — microbiology — Posted on 2022-03-14
2365 Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant
Tai, W.; Chai, B.; Feng, S.; Zhuang, X.; Ma, J.; Pang, M.; Pan, L.; Yang, Z.; Tian, M.; Cheng, G.
10.1101/2022.03.13.484123 — microbiology — Posted on 2022-03-14
2367 Organellar transcripts dominate the cellular mRNA pool across plants of varying ploidy levels
Forsythe, E. S.; Grover, C. E.; Miller, E. R.; Conover, J. L.; Arick, M. A.; Chavarro, M. C. F.; Leal-Bertioli, S. C. M.; Peterson, D. G.; Sharbrough, J.; Wendel, J. F.; Sloan, D. B.
10.1101/2022.03.12.484027 — plant biology — Posted on 2022-03-14
2368 Boosting transformation in wheat by BBM-WUS
Yan, W.; Xu, J.; Zhou, Z.; Yang, Y.; Ai, G.; Zhao, M.; Han, B.; Zhao, C.; Chen, Y.; Zhang, Y.; Pan, H.; Lan, C.; Li, Q.
10.1101/2022.03.13.483388 — plant biology — Posted on 2022-03-14
2370 Asymmetrical lineage introgression and recombination in populations of Aspergillus flavus: implications for biological control
Molo, M. S.; White, J. B.; Cornish, V.; Gell, R. M.; Baars, O.; Singh, R.; Carbone, M. A.; Isakeit, T.; Wise, K. A.; Woloshuk, C. P.; Bluhm, B. H.; Horn, B. W.; Heiniger, R. W.; Carbone, I.
10.1101/2022.03.12.484001 — evolutionary biology — Posted on 2022-03-14
2371 Landing manoeuvres predict roost-site preferences in bats
Chaverri, G.; Araya-Salas, M.; Barrantes, J. P.; Uribe-Etxebarria, T.; Pena-Acuna, M.; Varela, A. L.; Aihartza, J.
10.1101/2022.03.12.484101 — ecology — Posted on 2022-03-14
2373 A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions
Alekseev, A.; Pobegalov, G.; Morozova, N.; Vedyaykin, A.; Cherevatenko, G.; Yakimov, A.; Baitin, D.; Khodorkovskii, M.
10.1101/2022.03.14.484239 — molecular biology — Posted on 2022-03-14
2375 A consensus protocol for the recovery of mercury methylation genes from metagenomes
Capo, E.; Peterson, B. D.; Kim, M.; Jones, D. S.; Acinas, S. G.; Amyot, M.; Bertilsson, S.; Bjorn, E.; Buck, M.; Cosio, C.; Elias, D.; Gilmour, C.; Goni, M.; Gu, B.; Lin, H.; Liu, Y.-R.; McMahon, K.; Moreau, J. W.; Pinhassi, J. W.; Podar, M.; Puente-Sanchez, F.; Sanchez, P.; Storck, V.; Tada, Y.; Vigneron, A.; Walsh, D. A.; Vandewalle-Capo, M.; Bravo, A. G.; Gionfriddo, C. M.
10.1101/2022.03.14.484253 — microbiology — Posted on 2022-03-14
2376 Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions
Pringle, E. S.; Duguay, B. A.; Bui-Marinos, M. P.; Mulloy, R. P.; Landreth, S. L.; Desireddy, K. S.; Dolliver, S. M.; Ying, S.; Caddell, T.; Slaine, P. D.; Bearne, S. L.; Falzarano, D.; Corcoran, J.; Khaperskyy, D. A.; McCormick, C.
10.1101/2022.03.10.483772 — microbiology — Posted on 2022-03-14
2377 N-Terminomic Changes of Neurons During Excitotoxicity Reveals Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection
Ameen, S. S.; Griem-Krey, N.; Dufour, A.; Hossain, M. I.; Hoque, A.; Sturgeon, S.; Nandurkar, H.; Draxler, D. F.; Medcalf, R. L.; Kamaruddin, M. A.; Lucet, I. S.; Leeming, M. G.; Liu, D.; Dhillon, A.; Lim, J. P.; Basheer, F.; Zhu, H.-J.; Bokhari, L.; Roulston, C.; Paradkar, P. N.; Kleifeld, O.; Clarkson, A. N.; Wellendorph, P.; Ciccotosto, G. D.; Williamson, N. A.; Ang, C.-S.; Cheng, H.-C.
10.1101/2022.03.13.484119 — neuroscience — Posted on 2022-03-14
2383 Revisiting Ancient Polyploidy in Leptosporangiate Ferns
Chen, H.; Fang, Y.; Zwaenepoel, A.; Huang, S.; Van de Peer, Y.; Li, Z.
10.1101/2022.03.12.484015 — evolutionary biology — Posted on 2022-03-14
2390 Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit
Li, X.; Li, Y.; Zhou, Y.; Wu, J.; Zhao, Z.; Fan, J.; Deng, F.; Wu, Z.; Xiao, G.; He, J.; Zhang, Y.; Zhang, G.; Hu, X.; Zhang, Y.; Qiao, H.; Xie, H.; Li, Y.; Wang, H.; Fang, L.; Dai, Q.
10.1101/2022.03.14.484230 — biophysics — Posted on 2022-03-14
2394 A Microengineered Brain-Chip to Model Neuroinflammation in Humans
Pediaditakis, I.; Kodella, K. R.; Manatakis, D. V.; Le, C. Y.; Barthakur, S.; Sorets, A.; Gravanis, A.; Ewart, L.; Rubin, L. L.; Manolakos, E. S.; Hinojosa, C. D.; Karalis, K.
10.1101/2022.03.11.484005 — bioengineering — Posted on 2022-03-14
2395 Shared and distinct genetic etiologies for different types of clonal hematopoiesis
Brown, D. W.; Cato, L. D.; Zhao, Y.; Nandakumar, S. K.; Bao, E. L.; Rehling, T.; Song, L.; Yu, K.; Chanock, S. J.; Perry, J. R. B.; Sankaran, V. G.; Machiela, M. J.
10.1101/2022.03.14.483644 — genetics — Posted on 2022-03-14
2396 Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility
Olsen, L.; Levy, M.; Medley, J. K.; Hassan, H.; Alexander, R.; Wilcock, E.; Yi, K.; Florens, L.; McKinney, S.; Peuss, R.; Persons, J.; Kenzior, A.; Maldonado, E.; Gluesenkamp, A.; Mager, E.; Coughlin, D.; Rohner, N.
10.1101/2022.03.12.484091 — evolutionary biology — Posted on 2022-03-14
2397 Higher-order epistasis and phenotypic prediction
Zhou, J.; Wong, M. S.; Chen, W.-C.; Krainer, A. R.; Kinney, J. B.; McCandlish, D. M.
10.1101/2020.10.14.339804 — evolutionary biology — Posted on 2022-03-14
2398 Bacterioplankton taxa compete for iron along the early spring-summer transition in the Arctic Ocean
Puente-Sanchez, F.; Macias, L.; Campbell, K. L.; Royo-Llonch, M.; Balague, V.; Sanchez, P.; Tamames, J.; Mundy, C. J.; Pedros-Alio, C.
10.1101/2022.02.07.479392 — ecology — Posted on 2022-03-14
2399 Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events
Allen, G.; Weiss, B.; Panasenko, O. O.; Huch, S.; Villanyi, Z.; Albert, B.; Dilg, D.; Zagatti, M.; Schaughency, P.; Liao, S.; Corden, J.; Polte, C.; Shore, D.; Ignatova, Z.; Pelechano, V.; Collart, M. A.
10.1101/2022.03.14.484207 — molecular biology — Posted on 2022-03-14
2400 Diffusional variance-determined stochastic translation efficiency
Horvath, A.; Janapala, Y.; D. Hannah, R.; Eyras, E.; Preiss, T.; E. Shirokikh, N.
10.1101/2022.03.13.483370 — molecular biology — Posted on 2022-03-14
2401 Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy
Yu, J. S.; Heineike, B. M.; Hartl, J.; Correia-Melo, C.; Aulakh, S. K.; Lehmann, A.; Lemke, O.; Agostini, F.; Lee, C. T.; Demichev, V.; Messner, C. B.; Mülleder, M.; Ralser, M.
10.1101/2022.03.14.484209 — molecular biology — Posted on 2022-03-14
2402 Gram-negative Antimicrobial spectrum of Ulmus pumila
Schafer, J.; Puga, T. B.; Miller, S. R. T.; Agbedanu, P. N.
10.1101/2022.03.12.484112 — microbiology — Posted on 2022-03-14
2403 Molecular architecture of the TasA biofilm scaffold in Bacillus subtilis
Boehning, J.; Ghrayeb, M.; Pedebos, C.; Abbas, D.; Khalid, S.; Chai, L.; Bharat, T.
10.1101/2022.03.14.484220 — microbiology — Posted on 2022-03-14
2407 Examination of diurnal variation and sex differences in hippocampal neurophysiology and spatial memory
Goode, L. K.; Fusilier, A. R.; Remiszewski, N.; Reeves, J. M.; Abiraman, K.; Defenderfer, M.; Paul, J. R.; McMahon, L.; Gamble, K. L.
10.1101/2022.03.12.484083 — neuroscience — Posted on 2022-03-14
2410 Phyllochron duration and changes through rice development shape the vertical leaf size profile
Pablo, J. P.; Clerget, B.; Bueno, C.; Dionora, J.; Domingo, A. J.; De Guzman, C. C.; Aguilar, E. A.; Cadiz, N. M.; Sta Cuz, P. C.
10.1101/2022.03.12.484079 — plant biology — Posted on 2022-03-14
2412 Automated patch clamp screening of amiloride and 5-N,N-hexamethyleneamiloride (HMA) analogs identifies 6-iodoamiloride as a potent acid-sensing ion channel inhibitor.
Finol-Urdaneta, R. K.; McArthur, J. R.; Aboelela, A.; Bujaroski, R. S.; Majed, H. H.; Rangel, A.; Adams, D. J.; Ranson, M.; Kelso, M. J.; Buckley, B. J.
10.1101/2022.03.12.484055 — pharmacology and toxicology — Posted on 2022-03-14
2413 Generative and interpretable machine learning for aptamer design and analysis of in vitro sequence selection
Di Gioacchino, A.; Procyk, J.; Molari, M.; Schreck, J. S.; Zhou, Y.; Liu, Y.; Monasson, R.; Cocco, S.; Sulc, P.
10.1101/2022.03.12.484094 — biophysics — Posted on 2022-03-14
2414 Tension anisotropy drives phenotypic transitions of cells via two-way cell-ECM feedback
Alisafaei, F.; Shakiba, D.; Iannucci, L.; Davidson, M.; Pryse, K.; Chao, P.-h. G.; Burdick, J.; Lake, S.; Elson, E.; Shenoy, V.; Genin, G.
10.1101/2022.03.13.484154 — biophysics — Posted on 2022-03-14
2415 GRAPE: Genomic Relatedness Detection Pipeline
Medvedev, A.; Lebedev, M.; Ponomarev, A.; Kosaretskiy, M.; Osipenko, D.; Tischenko, A.; Kosaretskiy, E.; Wang, H.; Kolobkov, D.; Chamberlain-Evans, V.; Vakhitov, R.; Nikonorov, P.
10.1101/2022.03.11.483988 — bioinformatics — Posted on 2022-03-14
2422 The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding
Husby, M. L.; Amiar, S.; Prugar, L. I.; David, E. A.; Plescia, C. B.; Huie, K. E.; Brannan, J. M.; Dye, J. M.; Pienaar, E.; Stahelin, R. V.
10.1101/2021.06.08.447555 — microbiology — Posted on 2022-03-14
2425 Dimensionality reduction of calcium-imaged neuronal population activity
Koh, T. H.; Bishop, W. E.; Kawashima, T.; Jeon, B. B.; Srinivasan, R.; Kuhlman, S. J.; Ahrens, M. B.; Chase, S. M.; Yu, B. M.
10.1101/2022.03.11.480682 — neuroscience — Posted on 2022-03-14
2429 A Spatiotemporal Reconstruction of the C. elegans Pharyngeal Cuticle Reveals a Structure Rich in Phase-Separating Proteins
Kamal, M.; Tokmakjian, L.; Knox, J.; Mastrangelo, P.; Ji, J.; Cai, H.; Wojciechowski, J.; Hughes, M. P.; Takacs, K.; Chu, X.; Pei, J.; Grolmusz, V.; Kotulska, M.; Forman-Kay, J. D.; Roy, P. J.
10.1101/2022.03.11.483951 — systems biology — Posted on 2022-03-14
2431 Physiological trait networks enhance understanding of crop growth and water use in contrasting environments
Gleason, S. M.; Barnard, D. M.; Green, T. R.; Mackay, D. S.; Wang, D. R.; Ainsworth, E. A.; Altenhofen, J.; Brodribb, T. J.; Cochard, H.; Comas, L. H.; Cooper, M.; Creek, D.; DeJonge, K. C.; Delzon, S.; Fritschi, F. B.; Hammer, G.; Hunter, C.; Lombardozzi, D.; Messina, C. D.; Ocheltree, T.; Stevens, B. M.; Stewart, J. J.; Vadez, V.; Wenz, J.; Wright, I. J.; Yemoto, K.; Zhang, H.
10.1101/2022.03.11.482897 — plant biology — Posted on 2022-03-14
2432 3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast
Lewis, R.; Baskaran, H.; Green, J.; Tashev, S.; Palaiologou, E.; Lofthouse, E. M.; Cleal, J. K.; Page, A.; Chatelet, D.; Goggin, P.; Sengers, B. G.
10.1101/2022.01.26.477815 — physiology — Posted on 2022-03-14
2433 Comparing flickering and pulsed chromatic pupil light responses
Tripolone, C.; Issolio, L.; Aguero, C.; Lavaque, A.; Cao, D.; Barrionuevo, P. A.
10.1101/2022.03.11.483966 — physiology — Posted on 2022-03-14
2434 A Nematode-Selective Potentiator of Organophosphate and Carbamate Agrochemicals
Harrington, S.; Knox, J. J.; Burns, A. R.; Choo, K.-L.; Au, A.; Kitner, M.; Haeberli, C.; Pyche, J.; D'Amata, C.; Kim, Y.-H.; Volpatti, J.; Guiliani, M.; Snider, J.; Wong, V.; Palmeira, B. M.; Redman, E. M.; Vaidya, A. S.; Gilleard, J. S.; Stagljar, I.; Cutler, S. R.; Kulke, D.; Dowling, J. J.; Yip, C. M.; Keiser, J.; Zasada, I.; Lautens, M.; Roy, P.
10.1101/2022.03.12.484074 — pharmacology and toxicology — Posted on 2022-03-14
2435 Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages
Sheng, J.; Zhang, J.; Zhao, Y.; Song, J.; Tang, J.; Wang, X.; Ji, Y.; Wu, J.; Li, T.; Zhang, H.; Tano, V.; Langley, S. R.; Bai, X.; Liang, T.
10.1101/2022.03.11.483921 — pathology — Posted on 2022-03-14
2436 Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Lu, Y.; Cho, T.; Mukherjee, S.; Malik, A. A.; Gonzlez-Foutel, N.; Oh, R.; Langille, E.; Al-Zahrani, K.; Lin, Z.; Rotter, V.; Ashton-Prolla, P.; Chemes, L. B.; Moffat, J.; Gingras, A.-C.; Oren, M.; Durocher, D.; Schramek, D.
10.1101/2022.03.13.483372 — cancer biology — Posted on 2022-03-14
2441 OncoPubMiner: A platform for oncology publication mining
Xu, Q.; Liu, Y.; Sun, D.; Hu, J.; Duan, X.; Song, N.; Zhou, J.; Su, J.; Liu, S.; Chen, F.; Guo, Z.; Li, H.; Zhou, Q.; Niu, B.
10.1101/2022.03.11.483968 — bioinformatics — Posted on 2022-03-14
2442 A low-power communication scheme for wireless, 1000 channel brain-machine interfaces
Costello, J. T.; Nason, S. R.; An, H.; Lee, J.; Mender, M. J.; Temmar, H.; Wallace, D. M.; Lim, J.; Willsey, M. S.; Patil, P. G.; Jang, T.; Phillips, J. D.; Kim, H.-S.; Blaauw, D.; Chestek, C. A.
10.1101/2022.03.11.483996 — bioengineering — Posted on 2022-03-14
2444 Human myelin proteolipid protein structure and lipid bilayer stacking
Ruskamo, S.; Raasakka, A.; Pedersen, J. S.; Martel, A.; Skubnik, K.; Darwish, T.; Porcar, L.; Kursula, P.
10.1101/2022.03.14.484199 — biochemistry — Posted on 2022-03-14
2455 The AppNL-G-F mouse model of Alzheimer's disease is refractory to regulatory T cell treatment
Yshii, L.; Mascali, L.; Kouser, L.; Lemaitre, P.; Marino, M.; Dooley, J.; Burton, O.; Haughton, J.; Callaerts-Vegh, Z.; de Strooper, B.; Holt, M.; Pasciuto, E.; Liston, A.
10.1101/2022.03.11.483903 — immunology — Posted on 2022-03-14
2456 B cells are addicted to immunoglobulin production in the ER
Caganova, M.; Taskiran, H.; Zong, Y.; Zach, A.; Kabrani, E.; Schmidt, K.; Goffing, P.; Jellusova, J.; Rajewsky, K.
10.1101/2022.03.11.483940 — immunology — Posted on 2022-03-14
2460 A novel automated morphological analysis of microglia activation using a deep learning assisted model
Stetzik, L.; Mercado, G.; Smith, L.; George, S.; Quansah, E.; Schulz, E.; Meyerdirk, L.; Lindquist, A.; Bergsma, A.; Jones, R.; Brundin, L.; Henderson, M.; Pospisilik, A. J.; Brundin, P.
10.1101/2022.03.11.483994 — neuroscience — Posted on 2022-03-14
2462 A fungal endophyte-generated nucleoside signal regulates host cell death and promotes root colonization
Dunken, N.; Widmer, H.; Balcke, G. U.; Straube, H.; Langen, G.; Charura, N. M.; Saake, P.; Leson, L.; Roevenich, H.; Wawra, S.; Djamei, A.; Tissier, A. F.; Witte, C.-P. F.; Zuccaro, A.
10.1101/2022.03.11.483938 — plant biology — Posted on 2022-03-14
2463 Selective Control of Parasitic Nematodes Using Bioactivated Nematicides
Burns, A. R.; Ross, R. J.; Kitner, M.; Volpatti, J.; Vaidya, A. S.; Puumala, E.; Palmeira, B. M.; Redman, E. M.; Snider, J.; Marwah, S.; Chung, S. W.; MacDonald, M. H.; Tiefenbach, J.; Hu, C.; Xiao, Q.; Finney, C. A. M.; Krause, H.; MacParland, S.; Stagljar, I.; Gilleard, J. S.; Cowen, L.; Meyer, S. L. F.; Cutler, S. R.; Dowling, J. J.; Lautens, M.; Zasada, I.; Roy, P.
10.1101/2022.03.11.483960 — pharmacology and toxicology — Posted on 2022-03-14
2464 FPGA Acceleration of GWAS Permutation Testing
Swiel, Y.; Brandenburg, J.-T.; Hayat, M.; Chen, C.; Cox, M.; Hazelhurst, S.
10.1101/2022.03.11.483235 — bioinformatics — Posted on 2022-03-14
2469 Extensive gene duplication in Arabidopsis revealed by pseudo-heterozygosity
Jaegle, B.; Pisupati, R.; Soto-Jimenez, L. M.; Burns, R.; Rabanal, F. A.; Nordborg, M.
10.1101/2021.11.15.468652 — genomics — Posted on 2022-03-14
2470 Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins
Martinez, T. F.; Lyons-Abbott, S.; Bookout, A. L.; Donaldson, C.; Vaughan, J. M.; Lau, C.; Abramov, A.; Baquero, A. F.; Baquero, K.; Friedrich, D.; Huard, J.; Davis, R.; Kim, B.; Koch, T.; Mercer, A. J.; Misquith, A.; Murray, S. A.; Perry, S.; Pino, L. K.; Sanford, C.; Simon, A.; Zhang, Y.; Zipp, G.; Shokhirev, M. N.; Whittle, A. J.; Searle, B. C.; MacCoss, M. J.; Saghatelian, A.; Barnes, C. A.
10.1101/2022.03.12.484025 — systems biology — Posted on 2022-03-14
2473 Assessment of genetic diversity and SNP marker development within peanut germplasm in Taiwan by RAD-seq
Hsu, Y.-M.; Wang, S.-S.; Tseng, Y.-C.; Lee, S.-R.; Fang, H.; Hung, W.-C.; Kuo, H.-I.; Dai, H.-Y.
10.1101/2022.03.12.484056 — genetics — Posted on 2022-03-14
2474 Improved basic cytogenetics challenges holocentricity of butterfly chromosomes
Dutrillaux, B.; Dutrillaux, A.-M.; McClure, M.; Geze, M.; Elias, M.; Bed'Hom, B.
10.1101/2022.03.11.484012 — genetics — Posted on 2022-03-14
2475 The extinction of threatened species by anthropogenic threats endangers the functional diversity of turtles and crocodiles
Rodriguez-Caro, R. C.; Gracia, E.; Blomberg, S. P.; Cayuela, H.; Grace, M.; Carmona, C. P.; Perez-Mendonza, H. A.; Gimenez, A.; Salguero-Gomez, R.
10.1101/2022.03.11.483822 — ecology — Posted on 2022-03-14
2479 Metal Coordinating Inhibitors of Rift Valley Fever virus Replication
Geerling, E.; Murphy, V.; Stone, E. T.; Casals, A. G.; Hassert, M. A.; O'Dea, A. T.; Cao, F.; Donlin, M. J.; Elgendy, B. E.-D. M.; Elagawany, M.; Pardali, V.; Giannakopoulou, E.; Zoidis, G.; Schiavone, D. V.; Berkowitz, A. J.; Agyemang, N. B.; Murelli, R. P.; Tavis, J. E.; Pinto, A. K.; Brien, J. D. D.
10.1101/2022.03.10.483712 — microbiology — Posted on 2022-03-14
2480 Genome-resolved metaproteomics decodes the microbial and viral contributions to coupled carbon and nitrogen cycling in river sediments
Rodriguez-Ramos, J. A.; Borton, M. A.; McGivern, B.; Smith, G. J.; Solden, L.; Shaffer, M.; Daly, R. A.; Purvine, S. O.; Nicora, C. D.; Eder, E.; Lipton, M. S.; Hoyt, D. W.; Stegen, J. C.; Wrighton, K. C.
10.1101/2022.03.11.484050 — microbiology — Posted on 2022-03-14
2482 Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
Kiweler, N.; Delbrouck, C.; Pozdeev, V. I.; Neises, L.; Soriano-Baguet, L.; Eiden, K.; Xian, F.; Benzarti, M.; Haase, L.; Koncina, E.; Schmoetten, M.; Jaeger, C.; Noman, M. Z.; Vazquez, A.; Janji, B.; Dittmar, G.; Brenner, D.; Letellier, E.; Meiser, J.
10.1101/2021.05.27.445928 — cancer biology — Posted on 2022-03-14
2483 Sex-specific effects of an IgE polymorphism on immunity, susceptibility to infection and reproduction in a wild rodent
Wanelik, K. M.; Begon, M.; Bradley, J. E.; Friberg, I. M.; Jackson, J. A.; Taylor, C. H.; Paterson, S.
10.1101/841825 — ecology — Posted on 2022-03-14
2484 Influenza A Virus Compromises anti-Streptococcal Innate Immunity
Volzke, J.; Brendel, M.; Weipert, E.; Müller, M.; Schultz, D.; Karen Methling, Michael Lalk, Ulrike Blohm, Alexander Schäfer, Bernd Kreikemeyer, ; Müller-Hilke, B.
10.1101/2022.03.10.483890 — immunology — Posted on 2022-03-14
2486 Inhibitory interneurons show early dysfunction in a SOD1 mouse model of Amyotrophic Lateral Sclerosis
Cavarsan, C. F.; Steele, P. R.; McCane, L. M.; LaPre, K. J.; Puritz, A. C.; Katenka, N.; Quinlan, K. A.
10.1101/2020.10.21.348359 — neuroscience — Posted on 2022-03-14
2490 In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
Dervovic, D.; Chen, E. L. Y.; Malik, A.; Afiuni, S.; Boucher, J.; Berman, J. M.; Teng, K.; Ayyaz, A.; Lu, Y.; Narimatsu, M.; Mbamalu, G.; Loganathan, S.; Martinez, S.; Tsai, R.; Lee, J.-B.; Zhang, L.; Wrana, J.; Roux, P. P.; Jackson, H. W.; Schramek, D.
10.1101/2022.03.13.484176 — cancer biology — Posted on 2022-03-13
2491 In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
Martinez, S.; Weber, R.; Woo, T.; Malik, A.; Geuenich, M.; Jang, G. H.; Dervovic, D.; Al-Zahrani, K.; Tsai, R.; Fodil, N.; Gros, P.; Sidhu, S. S.; Gallinger, S.; Neely, G.; Campbell, K.; Notta, F.; Sendoel, A.; Schramek, D.
10.1101/2022.03.13.484174 — cancer biology — Posted on 2022-03-13
2500 Empirical study on software and process quality in bioinformatics tools
Ferenc, K.; Otto, K.; de Oliveira Neto, F. G.; Davila Lopez, M.; Horkoff, J.; Schliep, A.
10.1101/2022.03.10.483804 — bioinformatics — Posted on 2022-03-13
2503 Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility
Han, L.; Wu, S.; Peng, W.; Zhao, M.; Yue, C.; Wen, W.; Cai, W.; Zhang, T.; Wallny, H. J.; Avila, D. W.; Mwangi, W.; Nair, V.; Ternette, N.; Guo, Y.; Zhao, Y.; Chai, Y.; Qi, J.; Liang, H.; Gao, G. F.; Kaufman, J.; Liu, W. J.
10.1101/2022.03.11.484051 — immunology — Posted on 2022-03-13
2505 sDarken: Next generation genetically encoded fluorescent sensors for serotonin
Kubitschke, M.; Mueller, M.; Wallhorn, L.; Pulin, M.; Mittag, M.; Pollok, S.; Ziebarth, T.; Bremshey, S.; Gerdey, J.; Claussen, K. C.; Renken, K.; Gross, J.; Meyer, N.; Wiegert, S.; Reiner, A.; Fuhrmann, M.; Masseck, O. A.
10.1101/2022.03.10.483799 — neuroscience — Posted on 2022-03-13
2507 Systematic dissection of phosphorylation-dependent YAP1 complex formation elucidates a key role for PTPN14 in Hippo signal integration
Uliana, F.; Ciuffa, R.; Mishra, R.; Fossati, A.; Frommelt, F.; Mehnert, M.; Salmorin, E. B.; Peter, M.; Tapon, N.; Aebersold, R.; Gstaiger, M.
10.1101/2022.03.13.484137 — systems biology — Posted on 2022-03-13
2508 Beyond energy balance in agrivoltaic food production: Emergent crop traits from color selective solar cells
Charles, M.; Edwards, B.; Ravishankar, E.; Calero, J.; Henry, R.; Rech, J.; Saravitz, C.; You, W.; Ade, H.; O'Connor, B. T.; Sederoff, H.
10.1101/2022.03.10.482833 — plant biology — Posted on 2022-03-13
2513 CATHe: Detection of remote homologues for CATH superfamilies using embeddings from protein language models
Nallapareddy, V.; Bordin, N.; Sillitoe, I.; Heinzinger, M.; Littmann, M.; Waman, V.; Sen, N.; Rost, B.; Orengo, C.
10.1101/2022.03.10.483805 — bioinformatics — Posted on 2022-03-13
2514 Stack Mapping Anchor Points (SMAP): a versatile suite of tools for read-backed haplotyping
Schaumont, D.; Veeckman, E.; Van der Jeugt, F.; Haegeman, A.; van Glabeke, S.; Bawin, Y.; Lukasiewicz, J.; Blugeon, S.; Barre, P.; Leyva-Perez, M. d. l. O.; Byrne, S. L.; Dawyndt, P.; Ruttink, T.
10.1101/2022.03.10.483555 — genomics — Posted on 2022-03-13
2515 Ecology and evolution of chlamydial symbionts of arthropods
Halter, T.; Koestlbacher, S.; Collingro, A.; Sixt, B. S.; Toenshoff, E. R.; Hendrickx, F.; Kostanjsek, R.; Horn, M.
10.1101/2022.03.11.483957 — genomics — Posted on 2022-03-13
2517 Cortical interneuron loss and seizure generation as novel clinically relevant disease phenotypes in Cln2R207X mice
Takahashi, K.; Eultgen, E. M.; Wang, S. H.; Rensing, N. R.; Nelvagal, H. R.; Dearborn, J. T.; Sands, M. S.; Wong, M.; Cooper, J. D.
10.1101/2022.03.11.483984 — neuroscience — Posted on 2022-03-13
2518 Dynamics of brain-fluid circulation are altered in the mature-onset Tet-off APP mouse model of amyloidosis
Ben-Nejma, I. R. H.; Keliris, A. J.; Vanreusel, V.; Ponsaerts, P.; Van der Linden, A.; Keliris, G. A.
10.1101/2022.03.11.483807 — neuroscience — Posted on 2022-03-13
2520 Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site
Khadria, A.; Paavola, C. D.; Maslov, K.; Valenzuela, F. A.; Sperry, A. E.; Cox, A. L.; Cao, R.; Shi, J.; Brown-Augsburger, P. L.; Lozano, E.; Blankenship, R. L.; Majumdar, R.; Bradley, S. A.; Beals, J. M.; Oladipupo, S. S.; Wang, L. V.
10.1101/2022.03.10.483309 — systems biology — Posted on 2022-03-13
2525 High nutrient loads hinder successful restoration of natural habitats in freshwater wetlands
Moeslund, J. E.; Andersen, D. K.; Brunbjerg, A. K.; Floejgaard, C.; Nygaard, B.; Ejrnaes, R.
10.1101/2022.03.10.483603 — ecology — Posted on 2022-03-13
2535 Comprehensive phylogenomics of Methylobacterium reveals four evolutionary distinct groups and underappreciated phyllosphere diversity.
Leducq, J.-B.; Sneddon, D.; Santos, M.; Condrain-Morel, D.; Bourret, G.; Martinez-Gomez, N. C.; Lee, J. A.; Foster, J. A.; Shapiro, B. J.; Kembel, S. W.; Sullivan, J.; Marx, C. J.
10.1101/2022.03.12.484109 — genomics — Posted on 2022-03-13
2542 Maternal diet and gut microbiota influence predisposition to cardiovascular disease in the offspring
Jama, H. A.; Dona, M. I.; Dinakis, E.; Nakai, M.; Paterson, M. R.; Shihata, W.; Krstevski, C.; Cohen, C. D.; Weeks, K.; Farrugia, G. E.; Johnson, C.; Salimova, E.; Donner, D.; Kiriazis, H.; Kaipananickal, H.; Okabe, J.; Anderson, D.; Creek, D.; El-Osta, A.; Pinto, A. R.; Mackay, C. R.; Kaye, D. M.; Marques, F. Z.
10.1101/2022.03.12.480450 — microbiology — Posted on 2022-03-13
2543 Chondroitin Sulfate Proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction
Blake, M. R.; Parrish, D. C.; Staffenson, M. A.; Sueda, S.; Woodward, W. R.; Beth Habecker, B. A.
10.1101/2022.03.10.483746 — neuroscience — Posted on 2022-03-13
2545 Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Obeidat, A. M.; Wood, M. J.; Ishihara, S.; Li, J.; Wang, L.; Ren, D.; Bennett, D. A.; Miller, R. J.; Malfait, A.-M.; Miller, R. E.
10.1101/2022.03.12.484097 — physiology — Posted on 2022-03-13
2547 Helical ultrastructure of the oncogenic metalloprotease meprin α in complex with a small molecule hydroxamate inhibitor
Bayly-Jones, C.; Lupton, C. J.; Fritz, C.; Venugopal, H.; Ramsbeck, D.; Wermann, M.; Jager, C.; de Marco, A.; Schilling, S.; Schlenzig, D.; Whisstock, J. C.
10.1101/2022.03.13.484121 — biochemistry — Posted on 2022-03-13
2548 PP2A forestalls mitophagy by dephosphorylating Parkin and ubiquitin
Ye, S.-X.; Liu, X.-Y.; Nie, Z.-F.; Meng, L.-S.; Dong, X.; Li, F.-F.; Gong, Z.; Yang, W.; Zhang, W.-P.; Tang, C.
10.1101/2022.03.12.484070 — biochemistry — Posted on 2022-03-13
2549 Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM
Hawkes, W.; Marhuenda, E.; Reynolds, P. M.; O'Neill, C.; Pandey, P.; Wilson, D. G. S.; Freeley, M.; Huang, D.; Hu, J.; Gondarenko, S.; Hone, J.; Gadegaard, N.; Palma, M.; Iskratsch, T.
10.1101/2022.03.13.483961 — cell biology — Posted on 2022-03-13
2551 Focal Electrical Stimulation of Human Retinal Ganglion Cells for Vision Restoration
Madugula, S. S.; Gogliettino, A. R.; Zaidi, M.; Aggarwal, G.; Kling, A.; Shah, N. P.; Vilkhu, R.; Hays, M.; Nguyen, H.; Fan, V.; Wu, E. G.; Hottowy, P.; Sher, A.; Litke, A. M.; Silva, R. A.; Chichilnisky, E. J.
10.1101/2020.08.23.263608 — neuroscience — Posted on 2022-03-13
2556 Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice
Traut, J.; Mengual, J. P.; Meijer, E. J.; McKillop, L. E.; Alfonsa, H.; Hoerder-Suabedissen, A.; Song, S. M.; Molnar, Z.; Akerman, C. J.; Vyazovskiy, V. V.; Krone, L. B.
10.1101/2022.02.01.478652 — neuroscience — Posted on 2022-03-13
2557 Integration of multi-omics data reveals interplay between brassinosteroid and TORC signaling in Arabidopsis
Montes, C.; Wang, P.; Liao, C.-Y.; Nolan, T. M.; Song, G.; Clark, N. M.; Elmore, J. M.; Guo, H.; Bassham, D.; Yin, Y.; Walley, J.
10.1101/2022.03.11.484017 — plant biology — Posted on 2022-03-13
2561 Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less-functional
Nissley, D. A.; Jiang, Y.; Trovato, F.; Sitarik, I.; Narayan, K.; To, P.; Xia, Y.; Fried, S. D.; O'Brien, E. P.
10.1101/2021.08.18.456613 — biochemistry — Posted on 2022-03-13
2562 Improving replicability using interaction with laboratories: a multi-lab experimental assessment
Jaljuli, I.; Kafkafi, N.; Giladi, E.; Golani, I.; Gozes, I.; Chesler, E.; Bogue, M. A.; Bemjamini, Y.
10.1101/2021.12.05.471264 — animal behavior and cognition — Posted on 2022-03-13
2565 Actin binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II
Hayakawa, Y.; Takaine, M.; Ngo, K. X.; Imai, T.; Yamada, M.; Behjat, A. B.; Umeda, K.; Hirose, K.; Yurtsever, A.; Kodera, N.; Tokuraku, K.; Numata, O.; Fukuma, T.; Ando, T.; Nakano, K.; Uyeda, T.
10.1101/2020.04.14.041046 — biophysics — Posted on 2022-03-13
2566 Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts
Tomofuji, K.; Fukumitsu, K.; Kondo, J.; Horie, H.; Makino, K.; Wakama, S.; Ito, T.; Oshima, Y.; Ogiso, S.; Ishii, T.; Inoue, M.; Hatano, E.
10.1101/2021.11.14.468338 — bioengineering — Posted on 2022-03-13
2572 A Framework for Brain Atlases: Lessons from seizure Dynamics
Revell, A. Y.; Silva, A. B.; Arnold, T. C.; Stein, J. M.; Das, S. R.; Shinohara, R. T.; Bassett, D. S.; Litt, B.; Davis, K. A.
10.1101/2021.06.11.448063 — neuroscience — Posted on 2022-03-12
2573 DeCalciOn: A hardware system for real-time decoding of in-vivo calcium imaging data
Chen, Z.; Blair, G. J.; Guo, C.; Zhou, J.; Izquierdo, A.; Golshani, P.; Cong, J.; Aharoni, D.; Blair, H. T.
10.1101/2022.01.31.478424 — neuroscience — Posted on 2022-03-12
2574 Candidatus Liberibacter asiaticus reduces callose and reactive oxygen species production in the phloem
Bernardini, C.; Turner, D.; Wang, C.; Welker, S.; Achor, D.; Acanda, Y.; Turgeon, R.; Levy, A.
10.1101/2022.03.10.483847 — plant biology — Posted on 2022-03-12
2575 Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression
St. Pierre, C. L.; Macias-Velasco, J. F.; Wayhart, J. P.; Yin, L.; Semenkovich, C. F.; Lawson, H.
10.1101/2021.09.09.459642 — genomics — Posted on 2022-03-12
2578 The GHB analogue HOCPCA improves sensorimotor function after MCAO via CaMKIIα
Griem-Krey, N.; Klein, A. B.; Clausen, B. H.; Namini, M. R.; Nielsen, P. V.; Chin-Cheng, H.; Orset, C.; Vivien, D.; Clarkson, A. N.; Lambertsen, K. L.; Wellendorph, P.
10.1101/2022.03.10.483849 — pharmacology and toxicology — Posted on 2022-03-12
2579 EZH2 endorses cell plasticity to carcinoma cells facilitating mesenchymal to epithelial transition and tumour colonization
Gallardo, A.; Molina, A.; Asenjo, H. G.; Lopez-Onieva, L.; Alvarez-Perez, J. C.; Martorell-Marugan, J.; Cara, F. E.; Espinosa-Martinez, M.; Carmona-Saez, P.; Granados, S.; Medina, P.; Sanchez-Pozo, A.; Landeira, D.
10.1101/2022.03.11.483977 — cancer biology — Posted on 2022-03-12
2581 Snaq: A Dynamic Snakemake Pipeline for Microbiome data analysis with QIIME2
Mohsen, A.; Chen, Y.-A.; Allendes Osorio, R. S.; Higuchi, C.; Mizuguchi, K.
10.1101/2022.03.10.483866 — bioinformatics — Posted on 2022-03-12
2582 Protein arginine and lysine methylation in Trypanosoma cruzi
de Almeida, R. F.; Lucena, A. C. R.; Batista, M.; Marchini, F. K.; de Godoy, L. M. F.
10.1101/2022.03.12.484072 — genomics — Posted on 2022-03-12
2584 Opiate responses are controlled by interactions of Oprm1 and Fgf12 loci in the murine BXD family: Correspondence to human GWAS finding
Lemen, P. M.; Hatoum, A. S.; Dickson, P. E.; Mittleman, G.; Agrawal, A.; Reiner, B. C.; Berrettini, W.; Ashbrook, D. G.; Gunturkun, H.; Mulligan, M. K.; Williams, R. W.; Chen, H.
10.1101/2022.03.11.483993 — genetics — Posted on 2022-03-12
2585 Variation in cytonuclear expression accommodation among allopolyploid plants
Grover, C. E.; Forsythe, E. S.; Sharbrough, J.; Miller, E. R.; Conover, J. L.; DeTar, R. A.; Chavarro, C.; Arick, M. A.; Peterson, D. G.; Leal-Bertioli, S. C. M.; Sloan, D. B.; Wendel, J. F.
10.1101/2022.03.10.483839 — evolutionary biology — Posted on 2022-03-12
2587 Anatomical, ontogenetic, and genomic homologies guide reconstructions of the teeth-to-baleen transition in mysticete whales
Gatesy, J.; Ekdale, E. G.; Demere, T. A.; Lanzetti, A.; Randall, J.; Berta, A.; El Adli, J. J.; Springer, M. S.; McGowen, M. R.
10.1101/2022.03.10.483660 — evolutionary biology — Posted on 2022-03-12
2590 Interstrand Crosslinks in Donor DNA Boost Gene Editing in Human Cells
Ghasemi, H. I.; Bacal, J. I.; Yoon, A. I.; Cruz, C. I.; Vu, J. I.; Gardner, B. I.; Richardson, C. I.
10.1101/2022.03.11.484022 — molecular biology — Posted on 2022-03-12
2593 The pore-forming protein gasdermin D is a cellular redox sensor
Devant, P.; Borsic, E.; Ngwa, E. M.; Thiagarajah, J. R.; Hafner-Bratkovic, I.; Evavold, C. L.; Kagan, J. C.
10.1101/2022.03.11.484021 — immunology — Posted on 2022-03-12
2594 Purinergic P2X7 Receptor-mediated inflammation precedes PTSD-related Behaviors in Rats
Torres-Rodriguez, O.; Rivera-Escobales, Y.; Velazquez, B.; Colon, M.; Porter, J. T.
10.1101/2022.03.10.483788 — neuroscience — Posted on 2022-03-12
2597 ATR-I774Yfs*5 promotes genomic instability through micronuclei formation
D'Orazio, J.; Holcomb, N.; Pu, H.; Dhar, B.; Bautista, R.; Overmann, A.; Shelton, B.; Corum, L.
10.1101/2022.03.10.483800 — cancer biology — Posted on 2022-03-12
2601 New distribution data and phylogenetic approach reveal bioregionalization of the western Palearctic ants
Wang, R.; Kass, J. M.; Galkowski, C.; Garcia, F.; Hamer, M. T.; Radchenko, A.; Salata, S.; Schifani, E.; Yusupov, Z. M.; Economo, E. P.; Guenard, B.
10.1101/2022.03.10.483749 — zoology — Posted on 2022-03-12
2605 Cold-induced cyt elevations function to support osmoregulation in marine diatoms
Kleiner, F. H.; Helliwell, K. E.; Chrachri, A.; Hopes, A.; Parry-Wilson, H.; Gaikwad, T.; Mieszkowska, N.; Mock, T.; Wheeler, G. L.; Brownlee, C.
10.1101/2022.03.11.483981 — plant biology — Posted on 2022-03-12
2606 The pho1;2a'-m1.1 allele of Phosphate1 conditions mis-regulation of the phosphorus starvation response in maize (Zea mays ssp. mays L.)
Alonso-Nieves, A. L.; Salazar-Vidal, M. N.; Torres-Rodriguez, J. V.; Perez-Vazquez, L. M.; Massange-Sanchez, J. A.; Gillmor, C. S.; Sawers, R. J. H.
10.1101/2022.03.10.483828 — plant biology — Posted on 2022-03-12
2608 Systemic circulating microRNA landscape in Lynch syndrome
Sievänen, T.; Korhonen, T.-M.; Jokela, T.; Ahtiainen, M.; Lahtinen, L.; Kuopio, T.; Lepistö, A.; Sillanpää, E.; Mecklin, J.-P.; Seppälä, T. T.; Laakkonen, E. K.
10.1101/2022.03.10.483718 — cancer biology — Posted on 2022-03-12
2609 Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay
Touma, A. M.; Tang, W.; Rasicci, D. V.; Vang, D.; Rai, A.; Previs, S. B.; Warshaw, D. M.; Yengo, C. M.; Sivaramakrishnan, S.
10.1101/2022.03.11.483820 — biophysics — Posted on 2022-03-12
2610 Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
Mahadevan, J.; Jha, A.; Rudolph, J.; Bowerman, S.; Narducci, D.; Hansen, A. S.; Luger, K.
10.1101/2022.03.12.484081 — biophysics — Posted on 2022-03-12
2614 Combining two Genetic Sexing Strains allows sorting of non-transgenic males for Aedes genetic control
Lutrat, C.; Burckbuchler, M.; Olmo, R. P.; Beugnon, R.; Fontaine, A.; Baldet, T.; Bouyer, J.; Marois, E.
10.1101/2022.03.11.483912 — bioengineering — Posted on 2022-03-12
2617 Interspecies isobaric labeling-based quantitative proteomics reveals protein changes in the ovary of Aedes aegypti co-infected with ZIKV and Wolbachia
Ramos, L. F. C.; Martins, M.; Rodriguez, J. E.; Domont, G. B.; Oliveira, D. M. P. d.; Nogueira, F. C. S.; Maciel-de-Freitas, R.; Junqueira, M.
10.1101/2022.03.11.483997 — biochemistry — Posted on 2022-03-12
2619 Accurate detection of structural variation is hard
Lesack, K.; Mariene, G. M.; Andersen, E. C.; Wasmuth, J. D.
10.1101/2022.03.11.483485 — genomics — Posted on 2022-03-12
2622 The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor
Agrawal, R.; Gillies, J. P.; Zang, J. L.; Zhang, J.; Garrott, S. R.; Shibuya, H.; Nandakumar, J.; DeSantis, M. E.
10.1101/2022.03.11.483947 — cell biology — Posted on 2022-03-12
2623 Loss of tumor suppressor WWOX enhances RAS activity in pancreatic cancer
Husanie, H.; Abu-Remaileh, M.; Abu-Tair, L.; Safadi, H.; Atlan, K.; Golan, T.; Aqeilan, R. I.
10.1101/2022.03.10.483835 — cancer biology — Posted on 2022-03-12
2624 Cryo-EM structure of amyloid fibril formed by α-synuclein familial A53E mutation
Jiang, L.; sun, c.; zhou, k.; DePaola, P.; Shin, W. S.; Hillyer, T.; Sawaya, M. R.; Zhou, H.
10.1101/2022.03.11.483992 — biophysics — Posted on 2022-03-12
2626 Oligomer-to-Monomer Transition Underlies the Chaperone Function of AAGAB in AP1/AP2 Assembly
Tian, Y.; Datta, I.; Yang, R.; Wan, C.; Wang, B.; He, H.; Li, S.; Shen, J.; Yin, Q.
10.1101/2022.03.11.483825 — biochemistry — Posted on 2022-03-12
2628 Lrig3 restricts the size of the colon stem cell compartment
Stevenson, J. M.; Sayegh, R.; Pedicino, N.; Pellitier, N. A.; Wheeler, T. M.; Bechard, M. E.; Huh, W. J.; Coffey, R. J.; Zemper, A. E.
10.1101/2022.03.08.483523 — cell biology — Posted on 2022-03-12
2630 Deep learning in human neurons predicts mechanistic subtypes of Parkinson's
D'Sa, K.; Evans, J. R.; Virdi, G. S.; Vecchi, G.; Adam, A.; Bertolli, O.; Fleming, J.; Chang, H.; Athauda, D.; Choi, M. L.; Gandhi, S.
10.1101/2022.03.10.482156 — cell biology — Posted on 2022-03-12
2633 Resolving clonal substructure from single cell genomic data using CopyKit
Navin, N.; Minussi, D. C.; Sei, E.; Wang, J.; Schalck, A.; Yan, Y.; Davis, A.; Wu, H.-J.; Bai, S.; Peng, C.; Hu, M.; Casasent, A.; Contreras, A.; Chen, H.; Hui, D.; Damodaran, S.; Edgerton, M.; Kopetz, S.; Lim, B.
10.1101/2022.03.09.483497 — genomics — Posted on 2022-03-12
2635 Prokaryotic phospholipid translocation by ubiquitous PplT domain proteins
Hauser, J. N.; Kengmo Tchoupa, A.; Zabel, S.; Nieselt, K.; Ernst, C. M.; Slavetinsky, C. J.; Peschel, A.
10.1101/2022.03.11.483950 — microbiology — Posted on 2022-03-12
2636 Placental inflammation leads to abnormal embryonic heart development
Ward, E. J.; Bert, S.; Fanti, S.; Dufton, N. P.; Malone, K. M.; Maughan, R. T.; Prin, F.; Volpato, L.-K.; Piovesan, A. P.; Perretti, M.; Marelli-Berg, F. M.; Nadkarni, S.
10.1101/2022.03.10.482611 — immunology — Posted on 2022-03-12
2640 Triosephosphate export from chloroplasts regulates flavonoid biosynthesis and permits high light acclimation through the inactivation of SnRK1
Zirngibl, M.-E.; Estopare Araguirang, G.; Kitashova, A.; Jahnke, K.; Rolka, T.; Kühn, C.; Nägele, T.; Richter, A. S.
10.1101/2022.03.09.483619 — plant biology — Posted on 2022-03-12
2641 Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies
Germon, Z. P.; Sillar, J. R.; Mannan, A.; Duchatel, R. J.; Staudt, D.; Murray, H. C.; Findlay, I. J.; Jackson, E. R.; McEwen, H. P.; Douglas, A. M.; Mclachlan, T.; Schjenken, J. E.; Skerrett-Byrne, D. A.; Huang, H.; Melo-Braga, M. N.; Plank, M. W.; Alvaro, F.; Chamberlain, J.; De Iuliis, G.; Aitken, J.; Nixon, B.; Wei, A. H.; Enjeti, A. K.; Lock, R. B.; Larsen, M. R.; Lee, H.; de Bock, C.; Verrills, N. M.; Dun, M. D.
10.1101/2022.03.09.483687 — cancer biology — Posted on 2022-03-12
2642 Reference genome choice and filtering thresholds jointly influence phylogenomic analyses
Rick, J. A.; Brock, C. D.; Lewanski, A. L.; Golcher-Benavides, J.; Wagner, C. E.
10.1101/2022.03.10.483737 — bioinformatics — Posted on 2022-03-12
2645 Observation of a single protein by ultrafast X-ray diffraction
Ekeberg, T.; Assalauova, D.; Bielecki, J.; Boll, R.; Daurer, B. J.; Eichacker, L. A.; Franken, L. E.; Galli, D. E.; Gelisio, L.; Gumprecht, L.; Gunn, L. H.; Hajdu, J.; Hartmann, R.; Hasse, D.; Ignatenko, A.; Koliyadu, J.; Kulyk, O.; Kurta, R.; Kuster, M.; Lugmayr, W.; Lübke, J.; Mancuso, A. P.; Mazza, T.; Nettelblad, C.; Ovcharenko, Y.; Rivas, D. E.; Rose, M.; Samanta, A. K.; Schmidt, P.; Sobolev, E.; Timneanu, N.; Usenko, S.; Westphal, D.; Wollweber, T.; Worbs, L.; Xavier, P. L.; Yousef, H.; Ayyer, K.; Chapman, H. N.; Sellberg, J. A.; Seuring, C.; Vartanyants, I. A.; Küpper, J.; Meyer, M.;
10.1101/2022.03.09.483477 — biophysics — Posted on 2022-03-12
2646 Hypoxia classifier for transcriptome datasets
Puente-Santamaria, L.; Sanchez-Gonzalez, L.; Ramos-Ruiz, R.; del Peso, L.
10.1101/2021.11.15.468572 — bioinformatics — Posted on 2022-03-12
2647 Optimized high-throughput screening of non-coding variants identified from genome-wide association studies
Morova, T.; Ding, Y.; Huang, C.-C. F.; Sar, F.; Schwarz, T.; Giambartolomei, C.; Baca, S. C.; Grishin, D.; Hach, F.; Gusev, A.; Freedman, M. L.; Pasaniuc, B.; Lack, N. A.
10.1101/2022.03.11.483985 — genetics — Posted on 2022-03-12
2650 A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development.
Wilderman, A.; D'haene, E.; Baetens, M.; Yankee, T. N.; Wentworth Winchester, E.; Glidden, N.; Roets, E.; Van Dorpe, J.; Vergult, S.; Cox, T. C.; Cotney, J.
10.1101/2022.03.10.483852 — developmental biology — Posted on 2022-03-12
2653 In vitro susceptibility to beta-lactam antibiotics and viability of Neisseria gonorrhoeae strains producing plasmid-mediated broad- and extended-spectrum beta-lactamases
Kandinov, I. D.; Gryadunov, D. A.; Vinokurova, A. S.; Antonova, O. V.; Kubanov, A. A.; Solomka, V. S.; Shagabieva, J. Z.; Deryabin, D. G.; Shaskolskiy, B. L.
10.1101/2022.03.11.483876 — microbiology — Posted on 2022-03-12
2654 Genetic mapping of APP and amyloid-β biology modulation by trisomy 21
Mumford, P.; Tosh, J.; Anderle, S.; Wikberg, E. G.; Lau, G.; Noy, S.; Cleverley, K.; Saito, T.; Saido, T. C.; Yu, E. Y.; Brinkmalm, G.; Portelius, E.; Blennow, K.; Zetterberg, H.; Tybulewicz, V.; Fisher, E.; Wiseman, F. K.
10.1101/2022.03.10.483782 — neuroscience — Posted on 2022-03-12
2655 A connectomics-based taxonomy of mammals
Suarez, L. E.; Yovel, Y.; van den Heuvel, M. E.; Sporns, O.; Assaf, Y.; Lajoie, G.; Misic, B.
10.1101/2022.03.11.483995 — neuroscience — Posted on 2022-03-12
2656 Web-based Histology Reference Atlas for the Freshwater Crustacean Daphnia magna
Ngu, M. S.; Vanselow, D. X.; Zaino, C. R.; Lin, A. Y.; Copper, J. E.; Beaton, M.; Colbourne, J. K.; Cheng, K. C.; Ang, K. C.
10.1101/2022.03.09.483544 — zoology — Posted on 2022-03-12
2659 Floating EMG Sensors and Stimulators Wirelessly Powered and Operated by Volume Conduction for Networked Neuroprosthetics
Becerra-Fajardo, L.; Krob, M. O.; Minguillon, J.; Rodrigues, C.; Welsch, C.; Tudela-Pi, M.; Comerma, A.; Oliveira Barroso, F.; Schneider, A.; Ivorra, A.
10.1101/2022.03.09.483628 — bioengineering — Posted on 2022-03-12
2660 Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis
Cavalieri, R.; Hazebroek, M. K.; Cotrim, C. A.; Lee, Y.; Kunji, E. R. S.; Jastroch, M.; Keipert, S.; Crichton, P. G.
10.1101/2022.02.03.478984 — biochemistry — Posted on 2022-03-12
2663 PMRT1, a Plasmodium specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development
Wichers, J. S.; Mesen-Ramirez, P.; Yu-Strzelczyk, J.; Fuchs, G.; Stäcker, J.; von Thien, H.; Alder, A.; Henshall, I.; Liffner, B.; Nagel, G.; Löw, C.; Wilson, D. W.; Spielmann, T.; Gao, S.; Gilberger, T.; Bachmann, A.; Strauss, J.
10.1101/2021.12.21.473770 — cell biology — Posted on 2022-03-12
2664 Alveolar regeneration following viral infection is independent of tuft cells
Que, J.; Huang, H.; Jiang, M.; Zhang, Y.; Biermann, J.; Melms, J. C.; Danielsson, J.; Fang, Y.; Yang, Y.; Qiang, L.; Liu, J.; Zhou, Y.; Wang, M.; Hu, Z.; Wang, T.; Saqi, A.; Sun, J.; Matsumoto, I.; Cardoso, W. V.; Emala, C.; Zhu, J.; Izar, B.; Mou, H.
10.1101/2022.03.11.483948 — cell biology — Posted on 2022-03-12
2665 Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls
Clarke, E. J.; Lima, C.; Anderson, J. R.; Castenheira, C.; Beckett, A.; James, V.; Hyett, J.; Goodacre, R.; Peffers, M. J.
10.1101/2022.03.11.483922 — molecular biology — Posted on 2022-03-12
2668 Influenza A Virus Compromises anti-Streptococcal Innate Immunity
Volzke, J.; Brendel, M.; Weipert, E.; Müller, M.; Schultz, D.; Müller-Hilke, B.; Karen Methling, Michael Lalk, Ulrike Blohm, Alexander Schäfer, Bernd Kreikemeyer,
10.1101/2022.03.10.483890 — immunology — Posted on 2022-03-12
2669 The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice
Abdulai-Saiku, S.; Gupta, S.; Wang, D.; Moreno, A.; Huang, Y.; Srivastava, D.; Panning, B.; Dubal, D.
10.1101/2022.03.09.483691 — neuroscience — Posted on 2022-03-12
2671 Pan-phylum In Silico Analyses of Nematode Endocannabinoid Signalling Systems Highlight Novel Opportunities for Parasite Drug Target Discovery
Crooks, B. A.; McKenzie, D.; Cadd, L.; McCoy, C.; McVeigh, P.; Marks, N.; Maule, A.; Mousley, A.; Atkinson, L. E.
10.1101/2022.03.09.483626 — neuroscience — Posted on 2022-03-12
2672 The role of UBE3A in the autism and epilepsy-related Dup15q syndrome using patient-derived, CRISPR-corrected neurons
Elamin, M.; Dumarchey, A.; Stoddard, C.; Robinson, T. M.; Cowie, C.; Gorka, D.; Chamberlain, S. J.; Levine, E. S.
10.1101/2022.03.11.483963 — neuroscience — Posted on 2022-03-12
2673 Characterization of dengue virus 3UTR RNA binding proteins in mosquitoes reveals that AeStaufen reduces subgenomic flaviviral RNA in saliva
Yeh, S.-C.; Diosa-Toro, M.; Tan, W. L.; Hain, A.; Xuan, C. Y. P.; Xiang, B. W. W.; Sannan, G. S.; Manuel, M. C.; Misse, D.; Mok, Y. K.; Pompon, J.
10.1101/2022.03.11.483893 — zoology — Posted on 2022-03-12
2674 Robust high-throughput phenotyping with deep segmentation enabled by a web-based annotator
Yuan, J.; Kaur, D.; Zhou, Z.; Nagle, M.; Doshi, N. A.; Behnoudfar, A.; Peremyslova, E.; Ma, C.; Strauss, S. H.; Li, F.
10.1101/2022.03.11.483823 — plant biology — Posted on 2022-03-12
2677 Mechanical stress driven by rigidity sensing governs epithelial stability
Sonam, S.; Balasubramaniam, L.; Lin, S.-Z.; Yow, I.; Jauma, I. P.; Jebane, C.; Karnat, M.; Toyama, Y.; Marcq, P.; Prost, J.; Mege, R.-M.; Rupprecht, J.-F.; Ladoux, B.
10.1101/2022.03.10.483785 — biophysics — Posted on 2022-03-12
2680 Age-related Immune-Stromal Networks Inhibit Response to Regenerative Immunotherapies
Han, J.; Cherry, C.; Mejias, J. C.; Ruta, A.; Maestas, D. R.; Pena, A.; Nguyen, H. H.; Yang, B.; Gray-Gaillard, E.; Rutkowski, N.; Tam, A. J.; Fertig, E. J.; Housseau, F.; Ganguly, S.; Moore, E.; Pardoll, D. M.; Elisseeff, J. H.
10.1101/2021.08.17.456641 — bioengineering — Posted on 2022-03-12
2683 Oxytocin and Emotional Tear in Dogs
Murata, K.; Nagasawa, M.; Onaka, T.; Kanemaki, N.; Nakamura, S.; Tsubota, K.; Mogi, K.; Kikusui, T.
10.1101/2022.03.09.483532 — animal behavior and cognition — Posted on 2022-03-12
2686 Analysis of synthetic genetic interactions of non-coding RNAs in Saccharomyces cerevisiae
Fraczek, M.; Timouma, S.; Balarezo-Cisneros, L. N.; Parker, S.; Duangrattanalert, K.; Feng, M. W.; Griffiths-Jones, S.; O'Keefe, R.; Delneri, D.
10.1101/2022.03.10.483001 — genetics — Posted on 2022-03-12
2688 Effects of disease emergence on invasive grass impacts
Kendig, A. E.; Adhikari, A. E.; Lane, B. R.; Wojan, C. M.; Kortessis, N.; Simon, M. W.; Barfield, M.; Harmon, P. F.; Holt, R. D.; Clay, K.; Goss, E. M.; Flory, S. L.
10.1101/2022.03.09.483680 — ecology — Posted on 2022-03-12
2692 ID1 and CEBPA Coordinate Epidermal Progenitor Cell Differentiation
Kantzer, C. G.; Yang, W.; Grommisch, D.; Vikhe Patil, K.; Hin-Min Mak, K.; Genander, M.
10.1101/2022.03.09.483653 — developmental biology — Posted on 2022-03-12
2693 Automated classification of estrous stage in rodents using deep learning
Wolcott, N.; Sit, K.; Raimondi, G.; Hodges, T.; Shansky, R.; Galea, L.; Ostroff, L.; Goard, M.
10.1101/2022.03.09.483678 — cell biology — Posted on 2022-03-12
2694 Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
Mirchandani, A. S.; Jenkins, S. J.; Bain, C. C.; Lawson, H.; Coelho, P.; Murphy, F.; Griffith, D.; Zhang, A.; Sanchez-Garcia, M. A.; Reyes, L.; Morrison, T.; Arienti, S.; Sadiku, P.; Watts, E.; Dickinson, R.; Clark, S.; Ly, T.; Lewis, D.; Kelly, V.; Spanos, C.; Musgrave, K.; Delaney, L.; Harper, I.; Scott, J.; Parkinson, N.; Rostron, A.; Baillie, J. K.; Clohisey, S. M. R.; Pridans, C.; Campana, L.; Starkey, P.; Simpson, A. J.; Dockrell, D.; Schwarze, J.; Hirani, N.; Ratcliffe, P.; Pugh, C.; Kranc, K.; Forbes, S.; Whyte, M.; Walmsley, S.
10.1101/2022.03.11.483935 — cell biology — Posted on 2022-03-12
2695 The role of Staphylococcus agnetis and Staphylococcus hyicus in the pathogenesis of buffalo fly skin lesions in cattle
Naseem, M. N.; Turni, C.; Gilbert, R.; Raza, A.; Allavena, R.; McGowan, M.; Constantinoiu, C.; Ong, C. T.; Tabor, A. E.; James, P.
10.1101/2022.03.11.483979 — microbiology — Posted on 2022-03-12
2696 Heteologous saRNA-Prime, DNA Dual-Antigen-Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies
Rice, A.; Verma, M.; Voigt, E.; Battisti, P.; Beaver, S.; Reed, S.; Dinkins, K.; Mody, S.; Zakin, L.; Tanaka, S.; Morimoto, B.; Higashide, W.; Olson, C. A.; Gabitzsch, E. R.; Safrit, J. T.; Spilman, P. R.; Casper, C.; Soon-Shiong, P.
10.1101/2021.11.29.470440 — immunology — Posted on 2022-03-12
2697 Alpha-1-antitrypsin binds to the glucocorticoid receptor with biological significance in macrophages
Bai, X.; Bai, A.; Tomasicchio, M.; Hagman, J.; Buckle, A.; Gupta, A.; Kadiyala, V.; Bevers, S.; Serban, K.; Kim, K.; Feng, Z.; Spiender, K.; Hagen, G.; Fornis, L. B.; Griffith, D. E.; Dzieciatkowska, M.; Sandhaus, R. A.; Gerber, A. N.; Chan, E. D.
10.1101/2022.03.11.483896 — immunology — Posted on 2022-03-12
2698 Electroencephalographic dynamics of rhythmicbreath-based meditation
Tripathi, V.; Bhasker, L.; Kharya, C.; Bhatia, M.; Kochupillai, V.
10.1101/2022.03.09.483685 — neuroscience — Posted on 2022-03-12
2699 Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain
Zhou, Y.-P.; Sun, Y.; Takahashi, K.; Belov, V.; Andrews, N.; Woolf, C. J.; Brugarolas, P.
10.1101/2022.03.09.483673 — neuroscience — Posted on 2022-03-12
2702 Brain signal predictions from multi-scale networks using a linearized framework
Hagen, E.; Magnusson, S. H.; Ness, T. V.; Halnes, G.; Babu, P. N.; Linssen, C.; Morrison, A.; Einevoll, G. T.
10.1101/2022.02.28.482256 — neuroscience — Posted on 2022-03-12
2703 A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
Tran, K. M.; Kawauchi, S.; Rezaie, N.; Liang, H. Y.; Arreola, M.; Cunda, C. D.; Phan, J.; Collins, S.; Walker, A.; Milinkeviciute, G.; Neumann, J.; Gomez-Arboledas, A.; Javonillo, D. I.; Tran, K.; Gantuz, M.; Forner, S.; Swarup, V.; Tenner, A. J.; LeFerla, F.; Wood, M. A.; Mortazavi, A.; MacGregor, G.; Green, K. N.
10.1101/2022.03.09.483490 — neuroscience — Posted on 2022-03-12
2704 Cellular stress in brain organoids is limited to a distinct and bioinformatically removable subpopulation.
Vertesy, A.; Eichmueller, O. L.; Naas, J.; Novatchkova, M.; Esk, C.; Balmana, M.; Ladstaetter, S.; Bock, C.; von Haeseler, A.; Knoblich, J. A.
10.1101/2022.03.11.483643 — neuroscience — Posted on 2022-03-12
2707 Connectomic Analysis of the Drosophila Lateral Neuron Clock Cells Reveals the Synaptic Basis of Functional Pacemaker Classes.
Shafer, O. T.; Gutierrez, G. J.; Li, K.; Mildenhall, A.; Spira, D.; Marty, J.; Lazar, A. A.; Fernandez, M. d. l. P.
10.1101/2022.03.02.482743 — neuroscience — Posted on 2022-03-12
2708 Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.
Bauza-Thorbrugge, M.; Banke, E.; Chanclon, B.; Peris, E.; Wu, Y.; Musovic, S.; Jonsson, C.; Stralfors, P.; Rorsman, P.; Olofsson, C. S.; Asterholm, I. W.
10.1101/2022.03.11.483886 — physiology — Posted on 2022-03-12
2709 Structure and function of diadenylate cyclase DacM from Mycoplasma ovipneumoniae
Fan, S.; Hao, X.; Zhou, X.; Zhang, Y.; Han, Y.; Xu, Z.; Ma, C.; Luo, H.; Qi, K.; Li, M.
10.1101/2022.03.11.483894 — pathology — Posted on 2022-03-12
2710 A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology
Lutnick, B. R.; Manthey, D.; Becker, J. U.; Ginley, B.; Moos, K.; Zuckerman, J. E.; Rodrigues, L.; Gallan, A. J.; Barisoni, L.; Alpers, C. E.; Wang, X.; Myakala, K.; Jones, B. A.; Levi, M.; Kopp, J. B.; Yoshida, T.; Han, S. S.; Jain, S.; Rosenberg, A. Z.; Jen, K. Y.; Sarder, P.; Kidney Precision Medicine Project,
10.1101/2021.08.16.456524 — pathology — Posted on 2022-03-12
2711 Flotillin-2 regulates EGFR activation, degradation, and cancer growth
Wisniewski, D. J.; Liyasova, M. S.; Korrapati, S.; Zhang, X.; Gilbert, S. F.; Catalano, A.; Voeller, D.; Guha, U. J.; Porat-Shliom, N.; Annunziata, C.; Lipkowitz, S.
10.1101/2022.03.11.483779 — cancer biology — Posted on 2022-03-12
2712 ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II.
Braun, T. P.; Estabrook, J.; Darmusey, L.; Coleman, D. J.; Schonrock, Z.; Smith, B. M.; Enright, T.; Taherinasab, A.; Coblentz, C.; Yashar, W.; Callahan, R.; Mohammed, H.; Druker, B. J.; Lusardi, T.; Maxson, J. E.
10.1101/2020.09.14.295295 — cancer biology — Posted on 2022-03-12
2717 Ion channel model reduction using manifold boundaries
Whittaker, D. G.; Wang, J.; Shuttleworth, J.; Venkateshappa, R.; Kemp, J. M.; Claydon, T. W.; Mirams, G. R.
10.1101/2022.03.11.483794 — biophysics — Posted on 2022-03-12
2718 CRISPRcleanR WebApp: an interactive web application for processing genome-wide pooled CRISPR-Cas9 viability screen
Vinceti, A.; De Lucia, R. R.; Cremaschi, P.; Perron, U.; Karakoc, E.; Mauri, L.; Fernandez, C.; Kluczynski, K. H.; Anderson, D. S.; Iorio, F.
10.1101/2022.03.11.483924 — bioinformatics — Posted on 2022-03-11
2720 Fabrication of Conductive Hollow Microfibers for Encapsulation of Astrocyte Cells
Alimoradi, N.; Nasirian, V.; Aykar, S. S.; McNamara, M. C.; Niaraki-Asli, A. E.; Montazami, R.; Makowski, A.; Hashemi, N. N.
10.1101/2022.03.09.483669 — bioengineering — Posted on 2022-03-11
2722 Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma.
Gentien, D.; Saberi-Ansari, E.; Servant, N.; Jolly, A.; De la Grange, P.; Nemati, F.; Liot, G.; Saule, S.; Teissandier, A.; Bourc'his, D.; Girard, E.; Wong, J.; Masliah-Planchon, J.; Rodrigues, M.; Villoing Gaude, L.; Reyes, C.; Henry, E.; Baulande, S.; M'kacher, R.; Jeandidier, E.; Nicolas, A.; Decaudin, D.; Cassoux, N.; Piperno-Neumann, S.; Stern, M.-H.; Gibcus, J. H.; Dekker, J.; Heard, E.; Roman-Roman, S.; Waterfall, J. J.
10.1101/2022.03.11.483767 — genomics — Posted on 2022-03-11
2729 Continuing decline of the eastern quoll in Tasmania
Cunningham, C.; Aandahl, Z.; Jones, M. E.; Hamer, R.; Johnson, C. N.
10.1101/2022.03.10.483855 — ecology — Posted on 2022-03-12
2730 Dopamine pathway characterization during the reproductive mode switch in the pea aphid
LE TRIONNAIRE, G.; HUDAVERDIAN, S.; RICHARD, G.; TANGUY, S.; GLEONNEC, F.; PRUNIER-LETERME, N.; GAUTHIER, J.-P.; TAGU, D.
10.1101/2020.03.10.984989 — developmental biology — Posted on 2022-03-11
2731 Thymus formation in uncharted embryonic territories.
Alcobia, I.; Gama-Carvalho, M.; Magalhaes, L.; Proa, V.; Henrique, D.; Neves, H.
10.1101/2022.03.09.483697 — developmental biology — Posted on 2022-03-11
2732 A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions
Detraux, D.; Caruso, M.; Feller, L.; Meurant, S.; Fransolet, M.; Mathieu, J.; Arnould, T.; Renard, P.
10.1101/2022.03.10.483773 — developmental biology — Posted on 2022-03-11
2734 Lrig3 restricts the size of the colon stem cell compartment
Stevenson, J. M.; Sayegh, R.; Pedicino, N.; Pellitier, N. A.; Wheeler, T. M.; Bechard, M. E.; Huh, W. J.; Coffey, R. J.; Zemper, A. E.
10.1101/2022.03.08.483523 — cell biology — Posted on 2022-03-11
2737 The cortical bone metabolome of C57BL/6J mice is sexually dimorphic
Welhaven, H. D.; Vahidi, G.; Walk, S. T.; Bothner, B.; Martin, S. A.; Heveran, C. M.; June, R. K.
10.1101/2021.08.06.455423 — cell biology — Posted on 2022-03-12
2738 SELF PRUNING 3C is a flowering repressor that modulates seed germination, root architecture and drought responses
Moreira, J. d. R.; Quinones, A.; Lira, B. S.; Robledo, J. M.; Curtin, S. J.; Vicente, M. H.; Ribeiro, D. M.; Ryngajllo, M.; Jimenez-Gomez, J. M.; Peres, L. E. P.; Rossi, M. M.; Zsögön, A.
10.1101/2022.03.10.483842 — molecular biology — Posted on 2022-03-11
2740 Kaposi's sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs
Murphy, J. C.; Schumann, S.; Harrington, E.; Vasconcelos, E.; Mottram, T. J.; Aspden, J.; Whitehouse, A.
10.1101/2022.03.11.483946 — microbiology — Posted on 2022-03-11
2741 Bartonella taylorii: A model organism for studying Bartonella infection in vitro and in vivo
Fromm, K.; Boegli, A.; Ortelli, M.; Wagner, A.; Bohn, E.; Malmsheimer, S.; Wagner, S.; Dehio, C.
10.1101/2022.03.11.483615 — microbiology — Posted on 2022-03-11
2743 Development of a tractable model system to mimic wood-ageing of beer on a lab scale
Bossaert, S.; Kocijan, T.; Winne, V.; Van Opstaele, F.; Schlich, J.; Herrera-Malaver, B.; Verstrepen, K. J.; De Rouck, G.; Lievens, B.; Crauwels, S.
10.1101/2022.03.11.483928 — microbiology — Posted on 2022-03-11
2744 A core transcriptional response for biofilm formation by Y. pseudotuberculosis
Mahmud, A. K. M. F.; Nilsson, K.; Soni, D. K.; Choudhury, R.; Navais, R.; Tuck, S.; Avican, K.; Faellman, M.
10.1101/2022.03.11.483923 — microbiology — Posted on 2022-03-11
2745 Increased receptor affinity and reduced recognition by specific antibodies contribute to immune escape of SARS-CoV-2 variant Omicron
Vogt, A.-C. S.; Augusto, G.; Martina, B.; Chang, X.; Nasrallah, G.; Speiser, D. E.; Vogel, M.; Bachmann, M. F.; Mohsen, M.
10.1101/2022.03.11.483934 — immunology — Posted on 2022-03-11
2746 HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine
Wood, M. J.; Marshall, J. N.; Hartley, V. L.; Liu, T.-C.; Iwai, K.; Stappenbeck, T. S.; MacDuff, D. A.
10.1101/2022.03.09.483650 — immunology — Posted on 2022-03-11
2747 Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver Cancers
Nagalo, B. M.; Zhou, Y.; Loeuillard, E. L.; Dumbauld, C.; Barro, O.; Elliott, N.; Baker, A. T.; Arora, M.; Bogenberger, J. M.; Meurice, N.; Petit, J.; Uson Junior, P. L. S.; Aslam, F.; Chamcheu, J. C.; Simoes, C. C.; Cannon, M.; Basnakian, A. G.; Post, S. R.; Barrett, M. T.; Duda, D. G.; Jacobs, B.; Vile, R.; Barry, M. A.; Roberts, L.; Lyas, S. I.; Borad, M.
10.1101/2022.03.10.483848 — immunology — Posted on 2022-03-11
2748 Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity
Garcia-Villalba, J.; Hurtado-Navarro, L.; Penin-Franch, A.; Molina-Lopez, C.; Martinez-Alarcon, L.; Angosto-Bazarra, D.; Baroja-Mazo, A.; Pelegrin, P.
10.1101/2022.03.04.483019 — immunology — Posted on 2022-03-11
2750 Innate immune response and distinct metabolomic signatures together drive and shape the SARS-CoV-2-specific T cell response during COVID-19
Binayke, A.; Zaheer, A.; Dandotiya, J.; Gupta, S. K.; Mani, S.; Tripathy, M. R.; Madan, U.; Shrivastava, T.; Kumar, Y.; Pandey, A. K.; Rathore, D. K.; Awasthi, A.
10.1101/2022.03.11.483930 — immunology — Posted on 2022-03-12
2757 Distinct neural codes in primate Hippocampus and Lateral Prefrontal Cortex during associative learning in virtual environments
Corrigan, B. W.; Gulli, R. A.; Doucet, G.; Roussy, M.; Luna, R.; Sachs, A. J.; Martinez-Trujillo, J. C.
10.1101/2021.08.20.457136 — neuroscience — Posted on 2022-03-11
2758 Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes
Palmateer, C. M.; Artikis, C.; Brovero, S. G.; Friedman, B.; Gresham, A.; Arbeitman, M. N.
10.1101/2022.03.09.483618 — neuroscience — Posted on 2022-03-11
2760 Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia
Goikolea, J.; Roussarie, J. P.; Gerenu, G.; Loera-Valencia, R.; Latorre-Leal, M.; Cedazo-Minguez, A.; Rodriguez-Rodriguez, P.; Maioli, S.
10.1101/2022.03.09.483648 — neuroscience — Posted on 2022-03-11
2765 Programming bacteria to sense environmental DNA for multiplexed pathogen detection
Cheng, Y.-Y.; Chen, Z.; Cao, X.; Ross, T. D.; Falbel, T. G. S.; Burton, B. M.; Venturelli, O. S.
10.1101/2022.03.10.483875 — synthetic biology — Posted on 2022-03-11
2767 Molecular and functional characterization of the mouse intracardiac nervous system
Lizot, G.; Pasqualin, C.; Tissot, A.; Pages, S.; Faivre, J.-F.; Chatelier, A.
10.1101/2021.10.15.464492 — physiology — Posted on 2022-03-11
2770 Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway
Wei, P.; Bott, A. J.; Cluntun, A. A.; Morgan, J. T.; Cunningham, C. N.; Schell, J. C.; Ouyang, Y.; Ficarro, S. B.; Marto, J. A.; Danial, N. N.; DeBerardinis, R. J.; Rutter, J.
10.1101/2021.08.26.457847 — cancer biology — Posted on 2022-03-11
2774 Tension Gauge Tethers as tension-dependent lifetime sensors
Liu, J.; Le, S.; Yao, M.; Huang, W.; Tio, Z.; Zhou, Y.; Yan, J.
10.1101/2022.03.11.483943 — biophysics — Posted on 2022-03-11
2775 Dynamic Network Curvature Analysis of RNA-Seq Data in Sarcoma
Elkin, R.; Oh, J. H.; Dela Cruz, F.; Deasy, J. O.; Kung, A. L.; Tannenbaum, A. R.
10.1101/2022.03.09.483487 — bioinformatics — Posted on 2022-03-11
2777 Clinical application of tumour in normal contamination assessment from whole genome sequencing
Mitchell, J.; Bartram, J.; Walker, S.; Chalker, J.; Zarowiecki, M.; Milite, S.; Genomics England Research Consortium, ; Sosinsky, A.; Caravagna, G.
10.1101/2022.03.09.483623 — bioinformatics — Posted on 2022-03-11
2779 Whole brain network analysis of neural synchrony and information flow during transition from wakefulness to light non-rapid eye movement sleep
Fan, J. M.; Kudo, K.; Verma, P.; Ranasinghe, K. G.; Morise, H.; Findlay, A. M.; Kirsch, H. E.; Raj, A.; Krystal, A. D.; Nagarajan, S. S.
10.1101/2022.03.09.483562 — bioengineering — Posted on 2022-03-11
2780 A Strategy to Quantify Myofibroblast Activation on a Continuous Spectrum
Hillsley, A.; Santoso, M.; Engels, S. M.; Contreras, L. M.; Rosales, A. M.
10.1101/2022.03.09.483659 — bioengineering — Posted on 2022-03-11
2783 GENESPACE: syntenic pan-genome annotations for eukaryotes
Lovell, J. T.; Sreedasyam, A.; Schranz, M. E.; Wilson, M. A.; Carlson, J. W.; Harkess, A.; Emms, D.; Goodstein, D. M.; Schmutz, J.
10.1101/2022.03.09.483468 — genomics — Posted on 2022-03-11
2784 Multivariate Genomewide Association Analysis by Iterative Hard Thresholding
Chu, B. B.; Ko, S.; Zhou, J. J.; Jensen, A.; Zhou, H.; Sinsheimer, J. S.; Lange, K. L.
10.1101/2021.08.04.455145 — genetics — Posted on 2022-03-11
2785 Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3
Cova, G.; Glaser, J.; Schoepflin, R.; Ali, S.; Prada-Medina, C. A.; Franke, M.; Falcone, R.; Federer, M.; Ponzi, E.; Ficarella, R.; Novara, F.; Wittler, L.; Timmermann, B.; Gentile, M.; Zuffardi, O.; Spielmann, M.; Mundlos, S.
10.1101/2022.02.09.479724 — genetics — Posted on 2022-03-11
2789 Longitudinal dynamics of microvascular recovery after acquired cortical injury
Lin, X.; Chen, L.; Jullienne Wislofsky, A.; Zhang, H.; Salehi, A.; Hamer, M.; Holmes, T. C.; Obenaus, A.; Xu, X.
10.1101/2022.03.09.483613 — neuroscience — Posted on 2022-03-11
2792 Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring
Kiefer, L.; Servito, G. I. F.; Rajkumar, S. M.; Langen, J.; Chiosso, A.; Buckley, A.; Cha, E. S.; Horta, A.; Mui, M. H.; Canzio, D.
10.1101/2022.03.09.483674 — genomics — Posted on 2022-03-11
2793 A distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development.
Wilderman, A.; D'haene, E.; Baetens, M.; Wentworth Winchester, E.; Glidden, N.; Roets, E.; Van Dorpe, J.; Vergult, S.; Cox, T. C.; Cotney, J.
10.1101/2022.03.10.483852 — developmental biology — Posted on 2022-03-11
2794 Epithelial monolayer development and tight junction assembly on nanopillar arrays
Yeste, J.; Illa, X.; Shashikanth, N.; Guimera Brunet, A.; Villa, R.; Turner, J. R.
10.1101/2022.03.09.483692 — cell biology — Posted on 2022-03-11
2795 A chemical molecule promotes Trop2+ biliary duct organoids differentiation into insulin-secreting cells
Liu, M.; Yu, W.; Wang, Y.; Yan, B.; Shang, J.; Zhang, C.; Wu, H.; Tai, S.; Jin, L.; Teng, C.-B.
10.1101/2022.03.10.483710 — cell biology — Posted on 2022-03-11
2796 An integrated cell atlas of the human lung in health and disease
Sikkema, L.; Strobl, D. C.; Zappia, L.; Madissoon, E.; Markov, N. S.; Zaragosi, L.-E.; Ansari, M.; Arguel, M.-J.; Apperloo, L.; Becavin, C.; Berg, M.; Chichelnitskiy, E.; Chung, M.-i.; Collin, A.; Gay, A. C.; Hooshiar Kashani, B.; Jain, M.; Kapellos, T.; Kole, T. M.; Mayr, C. H.; Papen, von, M.; Peter, L.; Ramirez-Suastegui, C.; Schniering, J.; Taylor, C. J.; Walzthoeni, T.; Xu, C.; Bui, L. T.; Donno, de, C.; Dony, L.; Guo, M.; Gutierrez, A. J.; Heumos, L.; Huang, N.; Ibarra, I. L.; Jackson, N. D.; Kadur Lakshminarasimha Murthy, P.; Lotfollahi, M.; Tabib, T.; Talavera-Lopez, C.; Travaglini, K.
10.1101/2022.03.10.483747 — cell biology — Posted on 2022-03-11
2797 Large-Scale Circuit Configuration for Flexible Sensory-Motor Decisions
van den Brink, R. L.; Hagena, K.; Wilming, N.; Murphy, P. R.; Buechel, C.; Donner, T. H.
10.1101/2022.03.10.483758 — neuroscience — Posted on 2022-03-11
2800 Efficacy and safety of a patch containing adipose-derived stem cells for skin wound healing. Results form a comprehensive pre-clinical evaluation program
Brembilla, N.; Modarressi, A.; Andre Levigne, D.; Brioudes, E.; Lanza, F.; Vuagnat, H.; Durual, S.; Marger, L.; Boehncke, W.-H.; Krause, K.-H.; Preynat-Seauve, O.
10.1101/2022.03.09.483580 — bioengineering — Posted on 2022-03-11
2801 {Pi}-{Pi} Interactions Stabilize PeptoMicelle-Based Formulations of Pretomanid Derivatives Leading to Promising Therapy Against Tuberculosis in Zebrafish and Mouse Models
Dal, N.-J. K.; Schafer, G.; Thompson, A. M.; Schmitt, S.; Redinger, N.; Alonso-Rodriguez, N.; Johann, K.; Ojong, J.; Wohlmann, J.; Best, A.; Koynov, K.; Zentel, R.; Shaible, U. E.; Griffiths, G.; Barz, M.; Fenaroli, F.
10.1101/2022.03.10.483770 — bioengineering — Posted on 2022-03-11
2802 Recombinant annexin A6 promotes membrane repair in a stem cell derived-cardiomyocyte model of dystrophic cardiomyopathy
Fullenkamp, D. E.; Willis, A. B.; Curtin, J. L.; Amaral, A. P.; Harris, S. I.; Burridge, P. W.; Demonbreun, A. R.; McNally, E. M.
10.1101/2022.03.09.483528 — bioengineering — Posted on 2022-03-11
2805 Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair
Barr, J.; Gentile, M. E.; Lee, S.; Kotas, M.; Fernanda de Mello Costa, M.; Holcomb, N. P.; Jaquish, A.; Palashikar, G.; Matsumoto, I.; Margolskee, R.; Cohen, N. A.; Sun, X.; Vaughan, A. E.
10.1101/2022.03.10.483754 — cell biology — Posted on 2022-03-11
2806 Type I interferons govern Zika virus resistance of human macrophages and microglia
Hanrath, A. T.; Hatton, C. F.; Gothe, F.; Browne, C.; Vowles, J.; Leary, P.; Cockell, S. J.; Cowley, S. A.; James, W. S.; Hambleton, S.; Duncan, C. J. A.
10.1101/2022.03.09.483671 — cell biology — Posted on 2022-03-11
2808 Lamin A/C mediated invaginations in the nuclear surface allow the nucleus to pass unimpeded through a dense array of fiber-like obstacles
Katiyar, A.; Zhang, J.; Antani, J. D.; Yu, Y.; Lele, P. P.; Reinhart-King, C. A.; Sniadecki, N. J.; Roux, K. J.; Dickinson, R. B.; Lele, T. P.
10.1101/2022.03.10.483838 — cell biology — Posted on 2022-03-11
2809 Actin-dependent recruitment of Ago2 to the zonula adherens
Bridges, M. C.; Nair-Menon, J.; Davis, M. E.; Kourtidis, A.
10.1101/2022.03.10.483874 — cell biology — Posted on 2022-03-11
2811 On optimal temozolomide scheduling for slowly growing gliomas
Segura-Collar, B.; Jimenez-Sanchez, J.; Gargini, R.; Dragoj, M.; Sepulveda, J. M.; Pesic, M.; Sanchez-Gomez, P.; Perez-Garcia, V. M.
10.1101/2022.03.10.482967 — cancer biology — Posted on 2022-03-11
2812 Diet suppresses tumour initiation by maintaining quiescence of mutation-bearing neural stem cells
Amodeo, V.; Davies, T.; Martinez-Segura, A.; Clements, M.; Simpson Ragdale, H.; Bailey, A.; Silva dos Santos, M.; MacRae, J. I.; Mokochinski, J.; Kramer, H.; Garcia-Diaz, C.; Gould, A. P.; Marguerat, S.; Parrinello, S.
10.1101/2022.03.09.483611 — cancer biology — Posted on 2022-03-11
2814 Systematic Characterization of Double Emulsion Droplets for Biological Applications
Calhoun, S. G. K.; Brower, K. K.; Chandran Suja, V.; Kim, G.; Wang, N.; McCully, A. L.; Kusumaatmaja, H.; Fuller, G. G.; Fordyce, P. M.
10.1101/2022.03.04.483054 — bioengineering — Posted on 2022-03-11
2815 Structural basis for APE1 processing DNA damage in the nucleosome
Weaver, T. M.; Hoitsma, N. M.; Spencer, J. J.; Gakhar, L.; Schnicker, N. J.; Freudenthal, B. D.
10.1101/2022.03.09.483662 — biochemistry — Posted on 2022-03-11
2817 CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
Suzuki, T.; Tatsukawa, T.; Sudo, G.; Delandre, C.; Pai, Y. J.; Miyamoto, H.; Raveau, M.; Shimohata, A.; Ohmori, I.; Hamano, S.-i.; Haginoya, K.; Uematsu, M.; Takahashi, Y.; Morimoto, M.; Fujimoto, S.; Osaka, H.; Oguni, H.; Osawa, M.; Ishii, A.; Hirose, S.; Kaneko, S.; Inoue, Y.; Moore, A. W.; Yamakawa, K.
10.1101/2021.09.17.460803 — neuroscience — Posted on 2022-03-11
2821 Comparison of sampling methods for small oxbow wetland fish communities
Osterhaus, D. M.; Leberg, S. S.; Pierce, C. L.; Stewart, T. W.; McCombs, A.
10.1101/2022.03.10.483761 — ecology — Posted on 2022-03-10
2822 Alterations to the broad-spectrum formin inhibitor SMIFH2 improve potency
Orman, M.; Landis, M.; Oza, A.; Nambiar, D.; Gjeci, J.; Song, K.; Huang, V.; Klestzick, A.; Hachicho, C.; Liu, S. Q.; Kamm, J. M.; Bartolini, F.; Vadakkan, J. J.; Rojas, C. M.; Vizcarra, C. L.
10.1101/2022.03.10.483826 — biochemistry — Posted on 2022-03-10
2825 Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis
Peffers, M. J.; Jacobsen, S.; Walters, M.; Bundgaard, L.; Diendorfer, A.; Hackl, M.; Clarke, E. J.; Anderson, J. R.
10.1101/2022.03.10.483752 — molecular biology — Posted on 2022-03-10
2826 Structure and mechanism of a mitochondrial AAA+ disaggregase CLBP
Wu, D.; Liu, Y.; Dai, Y.; Wang, G.; Lu, G.; Chen, Y.; Li, N.; Lin, J.; Gao, N.
10.1101/2022.03.10.483744 — molecular biology — Posted on 2022-03-10
2828 The characterization of multiple novel paramyxovirus species highlights the diverse nature of the subfamily Orthoparamyxovirinae
Vanmechelen, B.; Meurs, S.; Horemans, M.; Loosen, A.; Joly Maes, T.; Laenen, L.; Vergote, V.; Koundouno, F. R.; Magassouba, N.; Konde, M. K.; Conde, I. S.; Carroll, M. W.; Maes, P.
10.1101/2022.03.10.483612 — microbiology — Posted on 2022-03-10
2830 Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat generated by CRISPR/Cas9
Wang, M.; Qi, Y.; Cao, Y.; Zhang, X.; Wang, Y.; Zhang, J.; Liu, Q.; Zhou, Q.; Ai, Y.; Wei, S.; Wang, L.; Liu, G.; Lian, Z.; Han, H.
10.1101/2022.03.10.483745 — immunology — Posted on 2022-03-10
2833 Structural basis for APE1 processing DNA damage in the nucleosome
Weaver, T. M.; Hoitsma, N. M.; Spencer, J. J.; Freudenthal, B. D.; Gakhar, L.; Schnicker, N. J.
10.1101/2022.03.09.483662 — biochemistry — Posted on 2022-03-10
2834 Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)
Fuandila, N. N.; Gosselin-Grenet, A.-S.; Tilak, M.-K.; Bergmann, S. M.; Escoubas, J.-M.; Klafack, S.; Lusiastuti, A. M.; Yuhana, M.; Fiston-Lavier, A.-S.; Avarre, J.-C.; Cherif, E.
10.1101/2022.03.10.483410 — genomics — Posted on 2022-03-10
2835 Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases
Wang, S. K.; Nair, S.; Li, R.; Kraft, K.; Pampari, A.; Patel, A.; Kang, J. B.; Luong, C.; Kundaje, A.; Chang, H. Y.
10.1101/2022.03.09.483684 — genomics — Posted on 2022-03-10
2840 Development of a Novel Bruton's Tyrosine Kinase Inhibitor that exerts Anti-Cancer Activities Potentiates Response of Chemotherapeutic Agents In Multiple Myeloma Stem Cell-Like Cells
Elbezanti, W. O.; Al-Odat, O.; Chitren, R.; Singh, J. K.; Srivastava, S. K.; Gowda, K.; Amin, S.; Robertson, G. P.; Jonnalagadda, S. C.; Budak-Alpdogan, T.; Pandey, M. K.
10.1101/2022.03.10.483708 — molecular biology — Posted on 2022-03-10
2842 Rickettsia typhi peptidoglycan mapping with data-dependent tandem mass spectrometry
Oyler, B. L.; Rennoll-Bankert, K. E.; Verhoeve, V. I.; Rahman, M. S.; Azad, A. F.; Gillespie, J. J.; Goodlett, D. R.
10.1101/2022.03.10.483817 — microbiology — Posted on 2022-03-10
2843 Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease
Ranasinghe, K.; Verma, P.; Cai, C.; Xie, X.; Kudo, K.; Gao, X.; Lerner, H.; Mizuiri, D.; Strom, A.; Iaccarino, L.; La Joie, R.; Miller, B. L.; Gorno-Tempini, M. L.; Rankin, K. P.; Jagust, W. J.; Vossel, K.; Rabinovici, G.; Raj, A.; Nagarajan, S.
10.1101/2022.03.09.483594 — neuroscience — Posted on 2022-03-10
2844 Does deterministic coexistence theory matter in a finite world?
Schreiber, S.; Levine, J. M.; Godoy, O.; Kraft, N.; Hart, S.
10.1101/290882 — ecology — Posted on 2022-03-10
2845 Cohesin is required for meiotic spindle assembly independent of its role in cohesion in C. elegans
McNally, K. P.; Danlasky, B. M.; Barroso, C.; Gong, T.; Li, W.; Martinez-Perez, E.; McNally, F. J.
10.1101/2022.03.10.483728 — cell biology — Posted on 2022-03-10
2846 Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
Boroumand, P.; Prescott, D.; Mukherjee, T.; Bilan, P. J.; Wong, M.; Shen, J.; Tattoli, I.; Zhou, Y.; Li, A.; Sivasubramaniyam, T.; Shi, N.; Zhu, L. Y.; Liu, Z.; Robbins, C.; Philpott, D. J.; Girardin, S. E.; Klip, A.
10.1101/2020.12.07.414862 — immunology — Posted on 2022-03-10
2848 Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion
Ulyanova, A. V.; Cottone, C.; Adam, C. D.; Maheshwari, N.; Grovola, M. R.; Fruchet, O. E.; Alamar, J.; Koch, P. F.; Johnson, V. E.; Cullen, D. K.; Wolf, J. A.
10.1101/2022.03.08.483543 — neuroscience — Posted on 2022-03-10
2850 Remodeled Connexin 43 hemichannels alter cardiac excitability and promote arrhythmias
Lillo, M. A.; Munoz, M. F.; Gaul-Muller, K.; Shirokova, N.; Xie, L.-h.; Fraidenraich, D.; Contreras, J. E.
10.1101/2022.03.08.483464 — physiology — Posted on 2022-03-10
2853 Coevolution of the Tlx homeobox gene with medusa development (Cnidaria: Medusozoa)
Travert, M. K.; Boohar, R.; Sanders, S. M.; Nicotra, M. L.; Leclere, L.; Steele, R. E.; Cartwright, P.
10.1101/2022.03.08.483504 — evolutionary biology — Posted on 2022-03-10
2854 Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis
Li, L.; Freitag, J.; Asbrand, C.; Munteanu, B.; Wang, B.-T.; Zezina, E.; Didier, M.; Thill, G.; Rocher, C.; Herrmann, M.; Biesemann, N.
10.1101/2022.03.09.483621 — cell biology — Posted on 2022-03-10
2855 NAK associated protein 1 is required to activate Tank binding kinase 1 to regulate mitosis
Paul, S.; Sarraf, S.; Zavar, L.; Fritsch, L. E.; DeFoor, N.; Ordureau, A.; Pickrell, A. M.
10.1101/2022.03.09.483647 — cell biology — Posted on 2022-03-10
2856 Voltage-Sensing Phosphatase (VSP) Regulates Endocytosis-Dependent Nutrient Absorption in Chordate Enterocytes
Ratanayotha, A.; Matsuda, M.; Kimura, Y.; Takenaga, F.; Mizuno, T.; Hossain, M. I.; Higashijima, S.-i.; Kawai, T.; Ogasawara, M.; Okamura, Y.
10.1101/2022.03.10.483738 — cell biology — Posted on 2022-03-10
2858 The Vaccinia virus chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion
Pokorny, L.; Burden, J. J.; Albrecht, D.; Bamford, R.; Leigh, K. E.; Sridhar, P.; Knowles, T. J.; Modis, Y.; Mercer, J.
10.1101/2022.03.10.483741 — microbiology — Posted on 2022-03-10
2859 URB597 induces aggression in adult Lister Hooded rats
Warren, W. G.; Hale, E.; Papagianni, E. P.; Cassaday, H. J.; Stevenson, C. W.; Stubbendorff, C.
10.1101/2022.03.09.483601 — neuroscience — Posted on 2022-03-10
2860 Structural and cellular transcriptome foundations of human brain disease
Zeighami, Y.; Bakken, T. E.; Nickl-Jockschat, T.; Peterson, Z.; Jegga, A. G.; Miller, J. A.; Evans, A. C.; Lein, E.; Hawrylycz, M.
10.1101/2021.05.12.443911 — neuroscience — Posted on 2022-03-10
2861 A theory of cortical map formation in the visual brain
Najafian, S.; Koch, E.; Teh, K.-L.; Jin, J.; Rahimi-Nasrabadi, H.; Zaidi, Q.; Kremkow, J.; Alonso, J.-M.
10.1101/2022.01.10.475662 — neuroscience — Posted on 2022-03-10
2863 Single-cell Spatial Proteomic Imaging for Human Neuropathology
Vijayaragavan, K.; Cannon, B. J.; Tebaykin, D.; Bosse, M.; Baranski, A.; Oliveria, J.; Mrdjen, D.; Corces, R.; McCaffrey, E. F.; Greenwald, N.; Sigal, Y.; Khair, Z.; Bruce, T.; Bharadwaj, A.; Bukhari, S.; Montine, K.; Angelo, M.; Montine, T.; Bendall, S. C.
10.1101/2022.03.02.482730 — systems biology — Posted on 2022-03-10
2865 Accelerating Minimap2 for accurate long read alignment on GPUs
Sadasivan, H.; Maric, M.; Dawson, E.; Iyer, V.; Israeli, J.; Narayanasamy, S.
10.1101/2022.03.09.483575 — genomics — Posted on 2022-03-10
2868 MOSAIC: A Unified Trait Database to Complement Structured Population Models
Bernard, C.; Santos, G. S.; Deere, J.; Rodriguez-Caro, R.; Capdevila, P.; Kusch, E.; Gascoigne, S.; Jackson, J.; Salguero-Gomez, R.
10.1101/2022.03.09.483599 — ecology — Posted on 2022-03-10
2872 Phospholipase Cβ2 Promotes Vascular Endothelial Growth Factor Induced Vascular Permeability
Phoenix, K. N.; Yue, Z.; Yue, L.; Cronin, C. G.; Liang, B. T.; Hoeppner, L. H.; Claffey, K. P.
10.1101/2022.03.09.483667 — cell biology — Posted on 2022-03-10
2873 MRG proteins are shared by multiple protein complexes with distinct functions
Devoucoux, M.; Roques, C.; Lachance, C.; Lashgari, A.; Joly-Beauparlant, C.; Jacquet, K.; Alerasool, N.; Prudente, A.; Taipale, M.; Droit, A.; Lambert, J.-P.; Hussein, S. M. I.; Cote, J.
10.1101/2021.08.11.456009 — molecular biology — Posted on 2022-03-10
2874 Methionine uptake via SLC43A2 transporter is essential for regulatory T lymphocyte survival
Naaz, A.; Saini, N.; Padma, S.; Gahlot, P.; Walvekar, A.; Dutta, A.; Davathamizhan, U.; Sarin, A.; Laxman, S.
10.1101/2022.03.09.483598 — immunology — Posted on 2022-03-10
2875 PFTK1 kinase regulates axogenesis during development via RhoA activation.
Rodriguez Gonzalez, Y.; Kamkar, F.; Jafar-nejad, P.; Wang, S.; Qu, D.; Sanchez Alvarez, L.; Hawari, D.; Sonnenfeld, M.; Slack, R. S.; Albert, P.; Park, D. S.; Joselin, A.
10.1101/2022.01.11.475789 — neuroscience — Posted on 2022-03-10
2877 Vocalization categorization behavior explained by a feature-based auditory categorization model
Kar, M.; Pernia, M.; Williams, K.; Parida, S.; Schneider, N. A.; McAndrew, M.; Kumbam, I.; Sadagopan, S.
10.1101/2022.03.09.483596 — neuroscience — Posted on 2022-03-10
2878 Homophilic wiring principles underpin neuronal network topology in vitro
Akarca, D.; Dunn, A. W. E.; Hornauer, P. J.; Ronchi, S.; Fiscella, M.; Wang, C.; Terrigno, M.; Jagasia, R.; Vertes, P. E.; Mierau, S. B.; Paulsen, O.; Eglen, S. J.; Hierlemann, A.; Astle, D. E.; Schröter, M.
10.1101/2022.03.09.483605 — neuroscience — Posted on 2022-03-10
2882 Neuroendocrinology of the lung revealed by single cell RNA sequencing
Kuo, C. S.; Darmanis, S.; Diaz de Arce, A.; Liu, Y.; Almanzar, N.; Wu, T. T. H.; Quake, S. R.; Krasnow, M. A.
10.1101/2022.03.08.483399 — bioinformatics — Posted on 2022-03-10
2884 The conserved zinc-finger protein GTSF1helps PIWI proteins achieve their full catalytic potential
Arif, A.; Bailey, S.; Izumi, N.; Anzelon, T. A.; Ozata, D. M.; Andersson, C.; Gainetdinov, I.; MacRae, I. J.; Tomari, Y.; Zamore, P. D.
10.1101/2021.05.04.442675 — biochemistry — Posted on 2022-03-10
2886 Automated assembly of high-quality diploid human reference genomes
Jarvis, E. D.; Formenti, G.; Rhie, A.; Guarracino, A.; Yang, C.; Wood, J.; Tracey, A.; Thibaud-Nissen, F.; Vollger, M. R.; Porubsky, D.; Cheng, H.; Asri, M.; Logsdon, G. A.; Carnevali, P.; Chaisson, M.; Chin, C.-S.; Cody, S.; Collins, J.; Ebert, P.; Escalona, M.; Fedrigo, O.; Fulton, R. S.; Fulton, L. L.; Garg, S.; Ghurye, J.; Granat, A.; Green, E.; Hall, I. M.; Harvey, W. H.; Hasenfeld, P.; Hastie, A.; Haukness, M.; Jaeger, E. B.; Jain, M.; Kirsche, M.; Kolmogorov, M.; Korbel, J. O.; Koren, S.; Korlach, J.; Lee, J.; Li, D.; Lindsay, T.; Lucas, J.; Luo, F.; Marschall, T.; McDaniel, J.; Nie, F.
10.1101/2022.03.06.483034 — genomics — Posted on 2022-03-10
2887 Immediate perturbation of DNA methylation upon acute prenatal alcohol exposure in the mouse developing brain cortex
DUCHATEAU, A.; AUPERIN, N.; MIOZZO, F.; LE MOUEL, A.; KIRSH, O.; MOHAMED, M.; OTT, S.; SABERAN-DJONEIDI, D.; MEZGER, V.
10.1101/2022.03.09.481186 — genomics — Posted on 2022-03-10
2889 ITS-based assessment of Madagascar's fungal diversity and arrival of EcM fungi to the island
Rivas-Ferreiro, M.; Suz, L. M.; Skarha, S. M.; Rakotonasolo, F.; Dentinger, B.
10.1101/2022.03.09.483579 — ecology — Posted on 2022-03-10
2890 BMAL1 and MEX3A co-regulate intestinal stem cell succession
Chang, F.-P.; Wang, C.-K.; Chou, Y.-C.; Chen, T.-J.; Wu, Y.-W.; Sridharan, S.; Hsu, P.-H.; Hwang-Verslues, W. W.
10.1101/2022.03.08.483537 — cell biology — Posted on 2022-03-10
2895 Hippocampal Interneuronal Dysfunction and Hyperexcitability in Porcine Model of Concussion
Ulyanova, A. V.; Cottone, C.; Adam, C. D.; Maheshwari, N.; Grovola, M. R.; Fruchet, O. E.; Alamar, J.; Koch, P. F.; Johnson, V. E.; Cullen, D. K.; Wolf, J. A.
10.1101/2022.03.08.483543 — neuroscience — Posted on 2022-03-10
2899 Comparison of individualized behavioral predictions across anatomical, diffusion and functional connectivity MRI
Ooi, L. Q. R.; Chen, J.; Zhang, S.; Kong, R.; Tam, A.; Li, J.; Dhamala, E.; Zhou, J. H.; Holmes, A.; Yeo, B. T. T.
10.1101/2022.03.08.483564 — neuroscience — Posted on 2022-03-10
2900 Characterization of red fluorescent reporters for dual-color in vivo three-photon microscopy
Thornton, M. A.; Futia, G. L.; Stockton, M. E.; Ozbay, B. N.; Kilborn, K.; Restrepo, D.; Gibson, E. A.; Hughes, E. G.
10.1101/2021.10.18.464840 — neuroscience — Posted on 2022-03-10
2902 Targeting metabolic adaptations in the breast cancer liver metastatic niche using dietary approaches to improve endocrine therapy efficacy
Zuo, Q.; Mogol, A. N.; Liu, Y.-J.; Casiano, A. S.; Chien, C.; Drnevich, J.; Imir, O. B.; Kulkoyluoglu-Cotul, E.; Park, N. H.; Shapiro, D. J.; Park, B. H.; Ziegler, Y.; Katzenellenbogen, B. S.; Aranda, E.; O'Neill, J. D.; Raghavendra, A. S.; Tripathy, D.; Madak-Erdogan, Z.
10.1101/2021.09.07.458711 — cancer biology — Posted on 2022-03-10
2903 A rich get richer effect governs intracellular condensate size distributions
Lee, D. S. W.; Choi, C.-H.; Sanders, D. W.; Beckers, L.; Riback, J. A.; brangwynne, C. P.; Wingreen, N. S.
10.1101/2022.03.08.483545 — biophysics — Posted on 2022-03-10
2910 Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions
Pringle, E. S.; Duguay, B. A.; Bui-Marinos, M. P.; Mulloy, R. P.; Landreth, S. L.; Desireddy, K. S.; Dolliver, S. M.; Ying, S.; Caddell, T.; Slaine, P. D.; Bearne, S. L.; Falzarano, D.; Corcoran, J.; Khaperskyy, D. A.; McCormick, C.
10.1101/2022.03.10.483772 — microbiology — Posted on 2022-03-10
2913 Temporal continuity shapes visual responses of macaque face patch neurons
Russ, B. E.; Koyano, K. W.; Day-Cooney, J.; Perwez, N.; Leopold, D. A.
10.1101/2022.02.22.481478 — neuroscience — Posted on 2022-03-10
2916 DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection
Hausmann, F.; Ergen, C.; Khatri, R.; Marouf, M.; Hänzelmann, S.; Gagliani, N.; Huber, S.; Machart, P.; Bonn, S.
10.1101/2022.03.09.483600 — bioinformatics — Posted on 2022-03-10
2917 Protein complex prediction with AlphaFold-Multimer
Evans, R.; O'Neill, M.; Pritzel, A.; Antropova, N.; Senior, A. W.; Green, T.; Zidek, A.; Bates, R.; Blackwell, S.; Yim, J.; Ronneberger, O.; Bodenstein, S.; Zielinski, M.; Bridgland, A.; Potapenko, A.; Cowie, A.; Tunyasuvunakool, K.; Jain, R.; Clancy, E.; Kohli, P.; Jumper, J.; Hassabis, D.
10.1101/2021.10.04.463034 — bioinformatics — Posted on 2022-03-10
2918 Reorganization of F-actin nanostructures is required for the late phases of SARS-CoV-2 replication in pulmonary cells.
Swain, J.; Merida, P.; Rubio, K.; Bracquemond, D.; Aguilar-Ordonez, I.; Guenther, S.; Barreto, G.; Muriaux, D.
10.1101/2022.03.08.483451 — microbiology — Posted on 2022-03-10
2919 The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis
Günther, A.; Hose, M.; Schumacher, F.; Kleuser, B.; Matuschewski, K.; Lang, K. S.; Gulbins, E.; Buer, J.; Westendorf, A.; Hansen, W.
10.1101/2022.03.08.483432 — microbiology — Posted on 2022-03-10
2920 MYB12 spatiotemporally represses TMO5/LHW-mediated transcription in the Arabidopsis root meristem
De Rybel, B.; Wybouw, B.; Arents, H. E.; Yang, B.-J.; Nolf, J.; Smet, W.; Vandorpe, M.; Van Damme, D.; Glanc, M.
10.1101/2022.03.08.483486 — plant biology — Posted on 2022-03-10
2924 Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies
Cao, Y.; Yisimayi, A.; Jian, F.; Xiao, T.; Song, W.; Wang, J.; Du, S.; Zhang, Z.; Liu, P.; Hao, X.; Li, Q.; Chen, X.; Wang, L.; Wang, P.; An, R.; Wang, Y.; Wang, J.; Yang, P.; Sun, H.; Zhao, L.; Zhang, W.; Zhao, D.; Zheng, J.; Yu, L.; Li, C.; Zhang, N.; Wang, R.; Niu, X.; Yang, S.; Song, X.; Zheng, L.; Li, Z.; Gu, Q.; Shao, F.; Huang, W.; Wang, Y.; Shen, Z.; Wang, X.; Jin, R.; Xiao, J.; Xie, X. S.
10.1101/2022.02.07.479349 — immunology — Posted on 2022-03-10
2926 Callosal fiber length scales with brain size according to functional lateralization, evolution, and development
Yang, L.; Zhao, C.; Xiong, Y.; Zhong, S.; Wu, D.; Peng, S.; Thiebaut de Schotten, M.; Gong, G.
10.1101/2021.04.01.437788 — neuroscience — Posted on 2022-03-10
2927 Lowland plant arrival in alpine ecosystems facilitates a decrease in soil carbon content under experimental climate warming
Walker, T. W. N.; Gavazov, K.; Guillaume, T.; Lambert, T.; Mariotte, P.; Routh, D.; Signarbieux, C.; Block, S.; Muenkemueller, T.; Nomoto, H.; Crowther, T. W.; Richter, A.; Buttler, A.; Alexander, J. M.
10.1101/2021.07.21.453211 — ecology — Posted on 2022-03-10
2929 Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills
Albertini, G.; D'Andrea, I.; Druart, M.; Bechade, C.; Nieves-Rivera, N.; Etienne, F.; Le Magueresse, C.; Rebsam, A.; Heck, N.; Maroteaux, L.; Roumier, A.
10.1101/2022.03.09.483609 — neuroscience — Posted on 2022-03-10
2931 Organ- and function-specific anatomical organization and bioelectronic modulation of the vagus nerve
Jayaprakash, N.; Toth, V.; Song, W.; Vardhan, A.; Levy, T.; Tomaio, J.; Qanud, K.; Mughrabi, I.; Chang, Y.-C.; Rob, M.; Daytz, A.; Abbas, A.; Ashville, J.; Vikatos, A.; Ahmed, U.; Nassrallah, Z.; Volpe, B.; Tracey, K. J.; Al-Abed, Y.; Datta-Chaudhuri, T.; Miller, L.; Barbe, M.; Lee, S.; Zanos, T.; Zanos, S.
10.1101/2022.03.07.483266 — neuroscience — Posted on 2022-03-10
2932 Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
Goutaudier, R.; Mallet, D.; Bartolomucci, M.; Guicherd, D.; Carcenac, C.; Vossier, F.; Dufourd, T.; Boulet, S.; Deransart, C.; Chovelon, B.; Carnicella, S.
10.1101/2021.12.24.474124 — neuroscience — Posted on 2022-03-10
2933 WDR82 mediated H3K4me3 is associated with tumor proliferation and therapeutic efficacy in pediatric high-grade gliomas
Wadhwani, N.; Nayak, S.; Wang, Y.; Hashizume, R.; Jie, C.; Mania-Farnell, B.; James, C. D.; Xi, G.; Tomita, T.
10.1101/2022.03.09.483606 — cancer biology — Posted on 2022-03-10
2935 Glucose-dependent miR-125b is a negative regulator of β-cell function
Cheung, R. W. S.; Pizza, G.; Chabosseau, P.; Rolando, D.; Tomas, A.; Burgoyne, T.; Wu, Z.; Salowka, A.; Thapa, A.; Macklin, A.; Cao, Y.; Nguyen-Tu, M.-S.; Dickerson, M. T.; Jacobson, D. A.; Marchetti, P.; Shapiro, J.; Piemonti, L.; de Koning, E. J. P.; Leclerc, I.; Bouzakri, K.; Sakamoto, K.; Smith, D. M.; Rutter, G. A.; Martinez-sanchez, A.
10.1101/2021.05.17.444559 — molecular biology — Posted on 2022-03-09
2936 Organ- and function-specific anatomical organization and bioelectronic modulation of the vagus nerve
Jayaprakash, N.; Toth, V.; Song, W.; Vardhan, A.; Levy, T.; Tomaio, J.; Qanud, K.; Mughrabi, I.; Chang, Y.-C.; Rob, M.; Daytz, A.; Abbas, A.; Ashville, J.; Vikatos, A.; Ahmed, U.; Nassrallah, Z.; Volpe, B.; Tracey, K. J.; Al-Abed,, Y.; Datta-Chaudhuri, T.; Miller, L.; Barbe, M.; Lee, S.; Zanos, T.; Zanos, S.
10.1101/2022.03.07.483266 — neuroscience — Posted on 2022-03-09
2941 Enhanced photosynthetic efficiency for increased carbon assimilation and woody biomass production in hybrid poplar INRA 717-1B4
Tao, Y.; Chiu, L.-W.; Hoyle, J. W.; Du, J.; Rasmussen, K.; Mellor, P.; Richey, C.; Kuiper, J.; Fried, M.; Dewhirst, R. A.; Tucker, D.; Crites, A.; Orr, G. A.; Heckert, M. J.; Vidal, D. G.; Orosco-Cardenas, M. L.; Hall, M. E.
10.1101/2022.02.16.480797 — plant biology — Posted on 2022-03-09
2942 Apolipoprotein M attenuates anthracycline cardiotoxicity and lysosomal injury
Guo, Z.; Valenzuela Ripoll, C.; Picataggi, A.; Rawnsley, D. R.; Ozcan, M.; Chirinos, J. A.; Chendamarai, E.; Girardi, A.; Riehl, T.; Evie, H.; Diab, A.; Kovacs, A.; Hyrc, K.; Ma, X.; Asnani, A.; Shewale, S. V.; Scherrer-Crosbie, M.; Cowart, L. A.; Parks, J. S.; Zhao, L.; Gordon, D.; Ramirez-Valle, F.; Margulies, K. B.; Cappola, T. P.; Desai, A. A.; Pederson, L. N.; Bergom, C.; Stitziel, N. O.; Rettig, M. P.; DiPersio, J. F.; Hajny, S.; Christoffersen, C.; Diwan, A.; Javaheri, A.
10.1101/2021.01.12.426397 — pharmacology and toxicology — Posted on 2022-03-09
2944 Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in mice
O'Keefe, R. N.; Carli, A.; Baloyan, D.; Sterle, S.; Eissmann, M. F.; Poh, A. R.; Seillet, C.; Locksley, R. M.; Ernst, M. M.; Buchert, M.
10.1101/2022.02.16.480779 — cancer biology — Posted on 2022-03-09
2945 Excitatory and inhibitory D-serine binding to the NMDA receptor
Yovanno, R. A.; Chou, T. H.; Brantley, S. J.; Furukawa, H.; Lau, A. Y.
10.1101/2022.03.07.483247 — biophysics — Posted on 2022-03-09
2948 Explainable t-SNE for single-cell RNA-seq data analysis
Han, H.; Zhang, T.; Benton, M. L.; Li, C.; Wang, J.; Li, J.
10.1101/2022.01.12.476084 — bioinformatics — Posted on 2022-03-09
2950 Spatial proteomics reveals subcellular reorganization in human keratinocytes exposed to UVA light
Valerio, H. P.; Ravagnani, F. G.; Candela, A. P. Y.; da Costa, B. D. C.; Ronsein, G. E.; Di Mascio, P.
10.1101/2021.09.01.458617 — biochemistry — Posted on 2022-03-09
2952 Acoustic regularities in infant-directed speech and song across cultures
Hilton, C. B.; Moser, C. J.; Bertolo, M.; Lee-Rubin, H.; Amir, D.; Bainbridge, C. M.; Simson, J.; Knox, D.; Glowacki, L.; Galbarczyk, A.; Jasienska, G.; Ross, C.; Neff, M. B.; Martin, A.; Cirelli, L. K.; Trehub, S. E.; Song, J.; Kim, M.; Schachner, A.; Vardy, T. A.; Atkinson, Q. D.; Antfolk, J.; Madhivanan, P.; Siddaiah, A.; Placek, C. D.; Salali, G. D.; Keestra, S.; Singh, M.; Collins, S. A.; Patton, J. Q.; Scaff, C.; Stieglitz, J.; Moya, C.; Sagar, R. R.; Wood, B. M.; Krasnow, M. M.; Mehr, S. A.
10.1101/2020.04.09.032995 — animal behavior and cognition — Posted on 2022-03-09
2954 The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk
Su, C.; Gao, L.; May, C. L.; Pippin, J. A.; Boehm, K.; Lee, M.; Liu, C.; Pahl, M.; Golson, M. L.; Naji, A.; The Human Pancreas Analysis Consortium, ; Grant, S. F. A.; Wells, A. D.; Kaestner, K. H.
10.1101/2021.11.30.470653 — genetics — Posted on 2022-03-09
2955 SATB1 undergoes isoform-specific phase transitions in T cells
Zelenka, T.; Tzerpos, P.; Panagopoulos, G.; Tsolis, K. C.; Papamatheakis, D.-A.; Papadakis, V. M.; Stanek, D.; Spilianakis, C.
10.1101/2021.08.11.455932 — molecular biology — Posted on 2022-03-09
2958 Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants
Zarn, K. E.; Jaramillo, S. A.; Zapata, A. R.; Stone, N. E.; Jones, A. N.; Nunnally, H. E.; Settles, E. W.; Ng, K.; Keim, P. S.; Knudsen, S.; Nuijten, P. M.; Tijsma, A. S.; French, C. T.
10.1101/2021.11.03.467186 — microbiology — Posted on 2022-03-09
2959 Structure of the IL-27 quaternary receptor signaling complex
Caveney, N. A.; Glassman, C. R.; Jude, K. M.; Tsutsumi, N.; Garcia, K. C.
10.1101/2022.03.08.483525 — immunology — Posted on 2022-03-09
2961 PyDesigner: A Pythonic Implementation of the DESIGNER Pipeline for Diffusion Tensor and Diffusional Kurtosis Imaging
Dhiman, S.; Teves, J. B.; Thorn, K. E.; McKinnon, E. T.; Moss, H. G.; Adisetiyo, V.; Ades-Aron, B.; Veraart, J.; Chen, J.; Fieremans, E.; Benitez, A.; Helpern, J. A.; Jensen, J. H.
10.1101/2021.10.20.465189 — neuroscience — Posted on 2022-03-09
2964 NLoed: A Python package for nonlinear optimal experimental design in systems biology
Braniff, N.; Pearce, T.; Lu, Z.; Astwood, M.; Forrest, W. S.; Receno, C.; Ingalls, B. P.
10.1101/2021.06.03.446189 — systems biology — Posted on 2022-03-09
2966 Surface interaction patches link non-specific binding and phase separation of antibodies
Ausserwöger, H.; Krainer, G.; Welsh, T. J.; Sneideris, T.; Schneider, M. M.; Invernizzi, G.; Herling, T. W.; Lorenzen, N.; Knowles, T. P. J.
10.1101/2022.03.07.483238 — biophysics — Posted on 2022-03-09
2968 CD5L constraints acute and systemic inflammation and can be a novel potent therapeutic agent against sepsis
Oliveira, L.; Gomes, A. P.; Santos, R. F.; Cardoso, M. S.; Novoa, A.; Luche, H.; Gärtner, F.; Malissen, B. M.; Mallo, M.; Carmo, A. M.
10.1101/2022.03.08.483540 — immunology — Posted on 2022-03-09
2970 Determinants of multiheme cytochrome extracellular electron transfer uncovered by systematic peptide insertion
Campbell, I. J.; Atkinson, J. T.; Carpenter, M. D.; Myerscough, D.; Su, L.; Ajo-Franklin, C. M.; Silberg, J. J.
10.1101/2022.03.09.483668 — synthetic biology — Posted on 2022-03-09
2971 Molecular profiling of XPO1 inhibitor and gemcitabine-nab-paclitaxel combination in cellular and LSL-Kras G12D/+; Trp53 fl/+; Pdx1-Cre (KPC) pancreatic cancer model
Uddin, M. H.; Aboukameel, A.; Li, Y.; Khan, H. Y.; Sexton, R. E.; Bannoura, S.; Dyson, G.; Al-Hallak, M. N.; Mzannar, Y.; Mohamed, A.; Landesman, Y.; Kim, S.; Beydoun, R.; Mohammad, R. M.; Shields, A. F.; Azmi, A. S.
10.1101/2022.03.08.481108 — cancer biology — Posted on 2022-03-09
2973 Lrig3 restricts the size of the colon stem cell compartment
Stevenson, J. M.; Sayegh, R.; Pedicino, N.; Pellitier, N. A.; Wheeler, T. M.; Bechard, M. E.; Huh, W. J.; Coffey, R. J.; Zemper, A. E.
10.1101/2022.03.08.483523 — cell biology — Posted on 2022-03-09
2974 Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosis
Chua, R. L. C.; Veith, C.; Schneider, M. A.; Jechow, K.; Xu, E. C.; Kreuter, M.; Boots, A. W.; Eils, R.; Kahn, N. C.; Conrad, C.
10.1101/2022.03.09.483638 — molecular biology — Posted on 2022-03-09
2976 Genomic landscape of the DHA1 family in the newly emerged pathogen Candida auris and mapping substrate repertoire of the prominent member CauMdr1
Khatoon, R.; Sharma, S.; Vishwakarma, P.; Saini, A.; Aggarwal, P.; Lynn, A. M.; Prakash, A.; Prasad, R.; Banerjee, A.
10.1101/2022.03.09.483563 — microbiology — Posted on 2022-03-09
2979 The therapeutic potential of D-Serine in reducing expression of the cytopathic genotoxin colibactin
Hallam, J. C.; O'Boyle, N.; Turner, N. C. A.; Tang-Fichaux, M.; Oswald, E.; Roe, A. J.
10.1101/2022.03.08.483572 — microbiology — Posted on 2022-03-09
2980 Unblocking genome editing of major animal mycoplasmas using CRISPR/Cas9 base editor systems
Ipoutcha, T.; Rideau, F.; Gourgues, G.; Arfi, Y.; Lartigue, C.; Blanchard, A.; Sirand-Pugnet, P.
10.1101/2022.03.09.483585 — microbiology — Posted on 2022-03-09
2981 Identification of a new Inovirus in the absence of bacterial infection in the human virome
Popgeorgiev, N.; Krupovic, M.; Hiblot, J.; Fancello, L.; Monteil-Bouchard, S.; Desnues, C.
10.1101/2022.03.09.483013 — microbiology — Posted on 2022-03-09
2986 Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations
Choudhary, G.; Pellagatti, A.; Agianian, B.; Smith, M.; Bhagat, T. D.; Gordon-Mitchell, S.; Pandey, S.; Shah, N.; Aluri, S.; Schwartz, L.; Steeples, V.; Booher, R.; Ramachandra, M.; Samson, M.; Carbajal, M.; Pradhan, K.; Bowman, T.; Pillai, M. M.; Will, B.; Wickrema, A.; Shastri, A.; Bradley, R. K.; Martell, R. E.; Steidl, U.; Gavathiotis, E.; Boultwood, J.; Starczynowski, D. T.; Verma, A.
10.1101/2022.03.09.483595 — cancer biology — Posted on 2022-03-09
2987 Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors
Du, J.; Meile, S.; Baggenstos, J.; Jaeggi, T.; Piffaretti, P.; Hunold, L.; Matter, C. I.; Leitner, L.; Kessler, T. M.; Loessner, M. J.; Kilcher, S.; Dunne, M.
10.1101/2022.03.09.483629 — bioengineering — Posted on 2022-03-09
2988 Temporin B forms hetero-oligomers with Temporin L, modifies its membrane activity and increases the cooperativity of its antibacterial pharmacodynamic profile
Ferguson, P. M.; Clarke, M.; Manzo, G.; Hind, C. K.; Clifford, M.; Sutton, J. M.; Lorenz, C. D.; Phoenix, D. A.; Mason, A. J.
10.1101/2022.03.09.483583 — biochemistry — Posted on 2022-03-09
2989 Tissue-Restricted Inhibition of mTOR Using Chemical Genetics
Wassarman, D. R.; Bankapalli, K.; Pallanck, L. J.; Shokat, K. M.
10.1101/2022.03.08.483534 — biochemistry — Posted on 2022-03-09
2990 Complex regulatory role of DNA methylation in caste- and age-specific expression of a termite.
Harrison, M. C.; Dohmen, E.; George, S.; Sillam-Dusses, D.; Seite, S.; Vassuer-Cognet, M.
10.1101/2022.03.08.483442 — evolutionary biology — Posted on 2022-03-09
2991 Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis
Ahmadvand, N.; Carraro, G.; Jones, M.; Shalashova, I.; Wihelm, J.; Baal, N.; Kosravi, F.; Chen, C.; Zhang, J.; Guenther, A.; Wasnick, R. M.; Bellusci, S.; Ruppert, C.
10.1101/2022.03.09.483616 — cell biology — Posted on 2022-03-09
2992 The ADP-heptose biosynthesis enzyme GmhB is a conserved Gram-negative bacteremia fitness factor
Holmes, C. L.; Smith, S. N.; Gurczynski, S. J.; Severin, G. B.; Unverdorben, L.; Vornhagen, J.; Mobley, H. L.; Bachman, M. A.
10.1101/2022.03.08.483568 — microbiology — Posted on 2022-03-09
2994 Do lanthanide-dependent microbial metabolisms drive the release of REEs from weathered granites?
Voutsinos, M. Y.; West-Roberts, J. A.; Sachdeva, R.; Moreau, J. W.; Banfield, J. F.
10.1101/2022.03.08.483559 — microbiology — Posted on 2022-03-09
2995 Performance of the cobas(R) HBV RNA Automated Investigational Assay for the Detection and Quantification of Circulating HBV RNA in Chronic HBV Patients
SCHOLTES, C.; Hamilton, A. T.; Plissonnier, M.-L.; Charre, C.; Scott, B.; Wang, L.; Berby, F.; French, J.; Testoni, B.; Blair, A.; Subic, M.; Hoppler, M.; Lankenau, A.; Grubenmann, A.; Levrero, M.; Heil, M.; Zoulim, F.
10.1101/2022.03.09.483670 — microbiology — Posted on 2022-03-09
2996 Comparative thermophysiology of marine Synechococcus CRD1 strains isolated from different thermal niches in iron-depleted areas
Ferrieux, M.; Dufour, L.; Dore, H.; Ratin, M.; Gueneugues, A.; Chasselin, L.; Marie, D.; Rigaut-Jalabert, F.; Le Gall, F.; Sciandra, T.; Monier, G.; Hoebeke, M.; Corre, E.; Xia, X.; Liu, H.; Scanlan, D. J.; Partensky, F.; Garczarek, L.
10.1101/2022.03.09.483587 — microbiology — Posted on 2022-03-09
2997 DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection
Hausmann, F.; Ergen, C.; Khatri, R.; Marouf, M.; Hänzelmann, S.; Gagliani, N.; Huber, S.; Machart, P.; Bonn, S.
10.1101/2022.03.09.483600 — bioinformatics — Posted on 2022-03-09
2999 Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants
Zarn, K. E.; Jaramillo, S. A.; Zapata, A. R.; Stone, N. E.; Jones, A. N.; Nunnally, H. E.; Settles, E. W.; Ng, K.; Keim, P. S.; Knudsen, S.; Nuijten, P. M.; Tijsma, A. S.; French, C. T.
10.1101/2021.11.03.467186 — microbiology — Posted on 2022-03-09
3001 Nucleocapsid-specific humoral responses improve the control of SARS-CoV-2
Dangi, T.; Sanchez, S.; Park, M.; Class, J.; Richner, M. C.; Richner, J. M.; Penaloza-MacMaster, P.
10.1101/2022.03.09.483635 — immunology — Posted on 2022-03-09
3004 Co-expression analysis reveals gene cluster associated with methylation of enhancers and chromosomal instability under TP63 and TRIM29 regulation
Sultanov, R. I.; Mulyukina, A.; Zubkova, O.; Fedoseeva, A.; Bogomazova, A.; Klimina, K.; Larin, A.; Zatsepin, T.; Prikazchikova, T.; Sharova, E.; Generozov, E. V.; Lagarkova, M. A.; Govorun, V. M.; Arapidi, G. P.
10.1101/2022.03.08.483320 — systems biology — Posted on 2022-03-09
3007 Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens
Pink, H.; Talbot, A.; Graceson, A.; Graham, J.; Higgins, G.; Taylor, A.; Jackson, A. C.; Truco, M.; Michelmore, R.; Yao, C.; Gawthrop, F.; Pink, D.; Hand, P.; Clarkson, J. P.; Denby, K.
10.1101/2022.03.08.483472 — plant biology — Posted on 2022-03-09
3008 Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules
Osten, J.; Mohebbi, M.; Uta, P.; Matinmehr, F.; Wang, T.; Kraft, T.; Amrute-Nayak, M.; Scholz, T.
10.1101/2022.03.08.483456 — physiology — Posted on 2022-03-09
3009 Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging
Petr, M. A.; Carmona-Marin, L. M.; Tulika, T.; Kristensen, S.; Reves, S.; Bakula, D.; Keijzers, G.; Osborne, B.; Mitchell, S. J.; Hamilton, S.; Kato, J.; Alfaras, I.; Teklu, A. A.; Heckenbach, I.; Madsen, J.; Ben Ezra, M.; Mkrtchyan, G.; Varner, E.; Fink, B.; von Krusenstiern, E.; Snyder, N. W.; Herranz, H.; de Cabo, R.; Scheibye-Knudsen, M.
10.1101/2022.03.08.483430 — physiology — Posted on 2022-03-09
3011 Nanobody-tethered transposition allows for multifactorial chromatin profiling at single-cell resolution
Stuart, T.; Hao, S.; Zhang, B.; Mekerishvili, L.; Landau, D.; Maniatis, S.; Satija, R.; Raimondi, I.
10.1101/2022.03.08.483436 — genomics — Posted on 2022-03-09
3014 A thermal radiator underlies plasticity to extreme temperatures in the world's largest bird
Svensson, E. I.; Schou, M. F.; Melgar, J.; Waller, J. T.; Engelbrecht, A.; Brand, Z.; Schalk, C. C.; Cornwallis, C. K.
10.1101/2022.03.08.483498 — evolutionary biology — Posted on 2022-03-09
3015 Comparative host-pathogen dynamics of Snake Fungal Disease in sympatric species of water snakes (Nerodia)
Harding, S. F.; Becker, C. G.; Yates, J.; Crump, P.; Forstner, M. R. J.; Mullin, S. J.; Rodriguez, D.
10.1101/2022.03.08.483470 — ecology — Posted on 2022-03-09
3016 Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
Wesley, B.; Ross, A.; Muraro, D.; Miao, Z.; Saxton, S.; Tomaz, R.; Morell, C.; Ridley, K.; Zacharis, E.; Petrus-Reurer, S.; Kraiczy, J.; Mahbubani, K.; Brown, S.; Garcia-Bernardo, J.; Alsinet, C.; Gaffney, D.; Tysoe, O.; Botting, R. A.; Stephenson, E.; Popescu, D.-M.; MacParland, S.; Bader, G. A.; Ortmann, D.; Sampaziotis, F.; Saeb-Parsy, K.; Haniffa, M.; Stevens, K.; Zilbauer, M.; Teichmann, S.; Vallier, L.
10.1101/2022.03.08.482299 — developmental biology — Posted on 2022-03-09
3018 The Olfm4-defined human neutrophil subsets differ in proteomic profile in septic shock
Lundquist, H.; Andersson, H.; Chew, M. S.; Das, J.; Turkina, M. V.; Welin, A.
10.1101/2022.03.08.483264 — immunology — Posted on 2022-03-09
3021 Repeat Detector: accurate, efficient, and flexible sizing of expanded CAG/CTG repeats from targeted DNA sequencing
Taylor, A. S.; Barros, D.; Gobet, N.; Schuepbach, T.; McAllister, B.; Aeschbach, L.; Randall, E. L.; Trofimenko, E.; Heuchan, E. R.; Barszcz, P.; Ciosi, M.; Morgan, J.; Hafford-Tear, N. J.; Davidson, A. E.; Massey, T. H.; Monckton, D. G.; Jones, L.; REGISTRY Investigators of the European Huntington's disease network, ; Xenarios, I.; Dion, V.
10.1101/2022.03.08.483398 — neuroscience — Posted on 2022-03-09
3028 A panoramic perspective on human phosphosites
Ramasamy, P.; Vandermarliere, E.; Vranken, W. F.; Martens, L.
10.1101/2022.03.08.483252 — bioinformatics — Posted on 2022-03-09
3030 Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy
Van de Sompele, S.; Small, K. W.; Cicekdal, M. B.; Soriano, V. L.; D'haene, E.; Shaya, F. S.; Agemy, S.; Van der Snickt, T.; Rey, A. D.; Rosseel, T.; Van Heetvelde, M.; Vergult, S.; Balikova, I.; Bergen, A. A.; Boon, C. J. F.; De Zaeytijd, J.; Inglehearn, C. F.; Kousal, B.; Leroy, B. P.; Rivolta, C.; Vaclavik, V.; van den Ende, J.; van Schooneveld, M. J.; Gomez-Skarmeta, J. L.; Tena, J. J.; Martinez-Morales, J. R.; Liskova, P.; Vleminckx, K.; De Baere, E.
10.1101/2022.03.08.481329 — genomics — Posted on 2022-03-09
3033 Alcohol-sourced acetate reduces T cell filamentous actin branching and migration
Azizov, V.; Frech, M.; Hofmann, J.; Kubankova, M.; Lapuente, D.; Tenbusch, M.; Guck, J.; Schett, G.; Zaiss, M. M.
10.1101/2022.03.08.483253 — immunology — Posted on 2022-03-09
3034 Stem cell regulators control a G1 duration gradient in the plant root meristem
Echevarria, C.; Desvoyes, B.; Marconi, M.; Franco-Zorrilla, J. M.; Lee, L.; Umeda, M.; Sablowski, R.; Birnbaum, K. D.; Wabnik, K.; Gutierrez, C.
10.1101/2022.03.09.483577 — plant biology — Posted on 2022-03-09
3038 ImputAccur: fast and user-friendly calculation of genotype-imputation accuracy-measures
Thormann, K. A.; Tozzi, V.; Starke, P.; Bickeboller, H.; Baum, M.; Rosenberger, A.
10.1101/2022.03.07.483268 — genomics — Posted on 2022-03-09
3040 SARS-CoV-2 triggers Golgi fragmentation via down-regulation of GRASP55 to facilitate viral trafficking
Zhang, J.; Kennedy, A.; Xing, L.; Bui, S.; Reid, W.; Joppich, J.; Ahat, E.; Rose, M.; Tang, Q.; Tai, A. W.; Wang, Y.
10.1101/2022.03.04.483074 — cell biology — Posted on 2022-03-09
3041 Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways
Petcherski, A.; Sharma, M.; Daskou, M.; Satta, S.; Vasilopoulos, H.; Hugo, C.; Ritou, E.; Dillon, B. J.; Fung, E.; Garcia, G.; Scafoglio, C.; Purkayastha, A.; Gomperts, B.; Fishbein, G. A.; Arumugaswami, V.; Liesa, M.; Shirihai, O. S.; Kelesidis, T.
10.1101/2022.02.22.481100 — microbiology — Posted on 2022-03-09
3042 Control of NK cell tolerance in MHC class I-deficiency by regulated SHP-1 localization to the activating immune synapse
Schmied, L.; Luu, T. T.; Sondergaard, J. N.; Meinke, S.; Mohammad, D. K.; Singh, S. B.; Mayer, C.; Perinetti Casoni, G.; Chrobok, M.; Schlums, H.; Rota, G.; Truong, H. M.; Westerberg, L. S.; Guarda, G.; Alici, E.; Wagner, A. K.; Kadri, N.; Bryceson, Y. T.; Saeed, M. B.; Hoglund, P.
10.1101/2022.03.08.483415 — immunology — Posted on 2022-03-09
3044 Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus.
Mondoloni, S.; Nguyen, C.; Vicq, E.; Jehl, J.; Durand-de Cuttoli, R.; Torquet, N.; Tolu, S.; Pons, S.; Maskos, U.; Marti, F.; Faure, P.; Mourot, A.
10.1101/2021.12.16.472949 — neuroscience — Posted on 2022-03-09
3046 A happy accident: a novel turfgrass reference genome
Phillips, A. R.; Seetharam, A. S.; AuBuchon-Elder, T.; Buckler, E. S.; Gillespie, L. J.; Hufford, M.; Llaca, V.; Romay, C.; Soreng, R. J.; Kellogg, E.; Ross-Ibarra, J.
10.1101/2022.03.08.483531 — plant biology — Posted on 2022-03-09
3048 Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction
Hindley, G.; Shadrin, A. A.; van der Meer, D.; Parker, N.; Cheng, W.; O'Connell, K. S.; Bahrami, S.; Lin, A.; Karadag, N.; Holen, B.; Bjella, T.; Fan, C. C.; Uelan, T.; Djurovic, S.; Smeland, O. B.; Frei, O.; Dale, A.; Andreassen, O.
10.1101/2022.02.28.481967 — genetics — Posted on 2022-03-09
3049 OPEN leaf: an open-source cloud-based phenotyping system for tracking dynamic changes at leaf-specific resolution in Arabidopsis
Swartz, L. G. A.; Liu, S.; Dahlquist, D.; Walter, E. S.; Kramer, S.; McInturf, S.; Bucksch, A.; Mendoza-Cozatl, D.
10.1101/2021.12.17.472861 — plant biology — Posted on 2022-03-09
3053 Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data
de Souza, V. B. C.; Jordan, B. T.; Tseng, E.; Nelson, E. A.; Hirschi, K. K.; Sheynkman, G. M.; Robinson, M. D.
10.1101/2022.02.08.479579 — bioinformatics — Posted on 2022-03-09
3057 Macrophages regulate gastrointestinal motility through complement component 1q
Pendse, M.; Li, Y.; Salinas, C. N.; Quinn, G.; Vo, N.; Propheter, D. C.; Dende, C.; Crofts, A. A.; Koo, E.; Hassell, B.; Ruhn, K. A.; Raj, P.; Obata, Y.; Hooper, L. V.
10.1101/2022.01.27.478097 — immunology — Posted on 2022-03-09
3058 CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model
Morera, C.; Kim, J.; Paredes-Redondo, A.; Nobles, M.; Rybin, D.; Moccia, R.; Kowala, A.; Meng, J.; Garren, S.; Liu, P.; Morgan, J. E.; Muntoni, F.; Christoforou, N.; Owens, J.; Tinker, A.; Lin, Y.-Y.
10.1101/2022.02.17.480850 — cell biology — Posted on 2022-03-09
3059 Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries
Peuhu, E.; Jacquemet, G.; Scheele, C. L.; Isomursu, A.; Paatero, I.; Thol, K.; Georgiadou, M.; Guzman, C.; Koskinen, S.; Laiho, A.; Elo, L. L.; Boström, P.; Hartiala, P.; van Rheenen, J.; Ivaska, J.
10.1101/2021.10.22.464987 — cell biology — Posted on 2022-03-09
3060 Organ- and function-specific anatomical organization and bioelectronic modulation of the vagus nerve
Jayaprakash, N.; Toth, V.; Song, W.; Vardhan, A.; Levy, T.; Tomaio, J.; Qanud, K.; Mughrabi, I.; Chang, Y.-C.; Rob, M.; Daytz, A.; Abbas, A.; Ashville, J.; Vikatos, A.; Ahmed, U.; Nassrallah, Z.; Volpe, B.; Tracey, K. J.; Al-Abed,, Y.; Datta-Chaudhuri, T.; Miller, L.; Barbe, M.; Lee, S.; Zanos, T.; Zanos, S.
10.1101/2022.03.07.483266 — neuroscience — Posted on 2022-03-09
3061 Hierarchical organization of spontaneous co-fluctuations in densely-sampled individuals using fMRI
Betzel, R.; Cutts, S.; Tanner, J.; Greenwell, S.; Varley, T.; Faskowitz, J.; Sporns, O.
10.1101/2022.03.06.483045 — neuroscience — Posted on 2022-03-09
3063 Ghrelin proteolysis by insulin-degrading enzyme
Bocach, D. D.; Jones, K. L.; Bell, J. M.; Zheng, Q.; Lazo, N. D.; Smith-Carpenter, J. E.; Alper, B. J.
10.1101/2021.06.10.447714 — biochemistry — Posted on 2022-03-09
3066 Phylogenomic analyses of Alismatales shed light into adaptations to aquatic environments
Chen, L.; Lu, B.; Morales-Briones, D. F.; Moody, M. L.; Liu, F.; Hu, G.-W.; Chen, J.-M.; Wang, Q.-F.
10.1101/2021.11.17.467373 — evolutionary biology — Posted on 2022-03-09
3069 Contribution of deep soil layers to the transpiration of a temperate deciduous forest: quantification and implications for the modelling of productivity
Maysonnave, J.; Delpierre, N.; Francois, C.; Jourdan, M.; Cornut, I.; Bazot, S.; Morfin, A.; Vincent, G.; Berveiller, D.
10.1101/2022.02.14.480025 — ecology — Posted on 2022-03-09
3070 No leeway to enhance carbon sequestration and stock capacity via changes to forest management
Dalmonech, D.; Marano, G.; Amthor, J.; Cescatti, A.; Lindner, M.; Trotta, C.; Collalti, A.
10.1101/2022.02.10.479900 — ecology — Posted on 2022-03-09
3071 N-VEGF, the autoregulatory arm of VEGF-A
Katsman, M.; Azriel, A.; Horev, G.; Reizel, Y.; Levi, B.-Z.
10.1101/2021.07.25.453721 — molecular biology — Posted on 2022-03-09
3072 EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin
Ponde, N. O.; Lortal, L.; Tsavou, A.; Hepworth, O. W.; Ho, J.; Richardson, J.; Moyes, D.; Gaffen, S.; Naglik, J. R.
10.1101/2022.03.05.483111 — microbiology — Posted on 2022-03-09
3073 CCL28 modulates neutrophil responses during infection with mucosal pathogens
Perez-Lopez, A.; Silva, S.; Lee, M.; Dillon, N.; Brandt, S.; Gerner, R.; Melchior, K.; Walker, G. T.; Sosa-Hernandez, V.; Cervantes-Diaz, R.; Romero-Ramirez, S.; Maravillas-Montero, J.; Nuccio, S.-P.; Nizet, V.; Raffatellu, M.
10.1101/2021.03.19.436197 — immunology — Posted on 2022-03-09
3074 Role of posterodorsal medial amygdala urocortin-3 in pubertal timing in female mice
Ivanova, D.; Li, X.; Liu, Y.; Mcintyre, C.; Fernandes, C.; Lass, G.; Kong, L.; O'Byrne, K.
10.1101/2022.01.27.477996 — neuroscience — Posted on 2022-03-09
3076 Selective neural coding of object, feature, and geometry spatial cues in humans
Ramanoël, S.; Durteste, M.; Bizeul, A.; Ozier-Lafontaine, A.; Becu, M.; Sahel, J.-A.; Habas, C.; Arleo, A.
10.1101/2021.04.28.441776 — neuroscience — Posted on 2022-03-09
3077 Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium
Reichel, F.; Kraeter, M.; Peikert, K.; Glass, H.; Rosendahl, P.; Herbig, M.; Prieto, A. R.; Kihm, A.; Kaestner, L.; Hermann, A.; Guck, J.
10.1101/2021.12.16.472921 — biophysics — Posted on 2022-03-09
3078 Integrated quality control of allele-specific copy numbers, mutations and tumour purity from cancer whole genome sequencing assays
Househam, J.; Bergamin, R.; Milite, S.; Calonaci, N.; Antonello, A.; Williams, M. J.; Cross, W. C. H.; Caravagna, G.
10.1101/2021.02.13.429885 — bioinformatics — Posted on 2022-03-09
3079 Ontogeny of superorganisms:Social control of queen specialization in ants
Majidifar, V.; Psalti, M. N.; Coulm, M.; Fetzer, E.; Teggers, E.-M.; Rotering, F.; Gruenewald, J.; Mannella, L.; Reuter, M.; Unte, D.; Libbrecht, R.
10.1101/2022.03.08.483434 — evolutionary biology — Posted on 2022-03-09
3081 A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2
Losa, M.; Barozzi, I.; Osterwalder, M.; Zarrineh, P.; Benazet, J.-D.; Chacon, B.; Girdziusaite, A.; Morabito, A.; Zhu, J.; Mackem, S.; Capellini, T. D.; Bobola, N.; Dickel, D.; Zuniga, A.; Visel, A.; Zeller, R.; Selleri, L.
10.1101/2022.03.08.483529 — developmental biology — Posted on 2022-03-09
3084 Multi-omic analysis along the gut-brain axis points to a functional architecture of autism
Morton, J. T.; Jin, D.-m.; Mills, R.; Shao, Y.; Rahman, G.; McDonald, D.; Harold-Berding, K.; Needham, B. D.; Zurita, M. F.; David, M.; Averina, O.; Kovtun, A.; Noto, A.; Mussap, M.; Wang, M.; Frank, D.; Li, E.; Zhou, W.; Fanos, V.; Danilenko, V.; Wall, D. P.; Cardenas, P. A.; Baldeon, M.; xavier, r. j.; Mazmanian, S.; Knight, R.; Gilbert, J.; Donovan, S.; Lawley, T.; Carpenter, B.; Bonneau, R.; Taroncher-Oldenburg, G.
10.1101/2022.02.25.482050 — microbiology — Posted on 2022-03-09
3085 Structure of the IL-1 27 quaternary receptor signaling complex
Caveney, N. A.; Glassman, C. R.; Jude, K. M.; Tsutsumi, N.; Garcia, K. C.
10.1101/2022.03.08.483525 — immunology — Posted on 2022-03-08
3087 Social closeness modulates brain dynamics during distrust anticipation
Jimenez, S.; Mercadillo-Caballero, R.; Angeles-Valdes, D.; Sanchez-Sosa, J. J.; Munoz-Delgado, J.; Garza-Villarreal, E. A.
10.1101/2022.03.08.483524 — neuroscience — Posted on 2022-03-09
3088 The oxytocin system regulates tearing
Nakamura, S.; Toshihiro, I.; Jin, K.; Shibuya, M.; Sakaguchi, H.; Izumiseki, F.; Tanaka, K. F.; Mimura, M.; Nishimori, K.; Kambara, N.; Hirayama, N.; Kamimura, I.; Nomoto, K.; Mogi, K.; Kikusui, T.; Mukai, Y.; Yamanaka, A.; Tsubota, K.
10.1101/2022.03.08.483433 — animal behavior and cognition — Posted on 2022-03-09
3089 A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer
Jiang, C.; Ward, N. P.; Prieto-Farigua, N.; Kang, Y. P.; Thalakola, A.; Teng, M.; DeNicola, G. M.
10.1101/2022.03.08.483452 — cancer biology — Posted on 2022-03-08
3093 Mechanical Ventilation induced P21 in an Acute Aging Model of Lung Injury
Gninzeko, F. J. K.; Tho, C. K.; Valentine, M. S.; Wandling, E. N.; Heise, R. L.
10.1101/2022.03.08.483505 — cell biology — Posted on 2022-03-08
3094 Mitochondrial TFAM in the Regulation of FOXP3+ T cell Mediated Maintenance of CD4+ T Cell Landscapes
Guo, K.; Debnath, T.; Wang, Z.; Jain, S.; Abrham, E.; Even, Z.; Mehta, H.; Lund, A.; Rahman, M.; Wu, M.; Wang, X.; Hur, J.; Ting, A.; Brown-Borg, H.; Jurivich, D. A.; Khan, N.; Mathur, R.
10.1101/2022.03.08.483517 — immunology — Posted on 2022-03-08
3095 Bayesian multi-model-based 13C15N-metabolic flux analysis quantifies carbon-nitrogen metabolism in mycobacteria
Borah, K.; Beyss, M.; Xu, Y.; Barber, J.; Costa, C.; Newcombe, J.; Theorell, A.; Bailey, M.; Beste, D. J.; McFadden, J.; Noh, K.
10.1101/2022.03.08.483448 — systems biology — Posted on 2022-03-08
3097 Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion
Deborde, S.; Gusain, L.; Powers, A.; Marcadis, A.; Yu, Y.; Chen, C.-H.; Frants, A.; Kao, E.; Omelchenko, T.; Tang, L.; Vakiani, E.; Calo, A.; Reva, B.; Jessen, K. R.; Wong, R. J.
10.1101/2022.03.08.481473 — cancer biology — Posted on 2022-03-08
3106 Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster
Peng, P.; Feng, C.; Hu, J.; He, C.-l.; Deng, H.; Fan, Q.; Tang, G.; Jiang, M.; Hu, F.; Li, F.; Wang, K.; Tang, N.; Tang, X.; Huang, A.
10.1101/2022.03.07.483373 — microbiology — Posted on 2022-03-08
3108 Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron
Jin, T.; Ma, H.; Zhang, X.; Zheng, P.; Dube, P. H.; Zeng, W.; Chen, S.; Yang, Y.; Wu, Y.; Zhou, J.; Hu, X.; Xiang, Y.; Zhang, H.; Chiu, S.
10.1101/2022.03.08.483381 — immunology — Posted on 2022-03-08
3109 The influence of learning on robustness of working memory to distractors
Ermolova, M.; Belyaeva, V.; Novikov, N.; Fedele, T.; Moiseeva, V.; Gutkin, B.; Feurra, M.
10.1101/2022.03.08.482959 — neuroscience — Posted on 2022-03-08
3110 Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
Al Khatib, I.; Deng, J.; Symes, S. A.; Zhang, H.; Huang, S.-y. N.; Pommier, Y.; Khan, A.; Gibson, W.; Shutt, T.
10.1101/2022.03.08.483326 — cell biology — Posted on 2022-03-08
3111 The importance of environmental parameters and mixing zone in shaping estuarine microbial communities along a freshwater-marine gradient.
da Silva, R. R. P.; White, C. A.; Bowman, J. P.; Bodrossy, L.; Bissett, A.; Revill, A.; Eriksen, R.; Ross, D. J.
10.1101/2022.03.07.483378 — microbiology — Posted on 2022-03-08
3112 RUNX1 isoform disequilibrium in the development of trisomy 21 associated myeloid leukemia
Gialesaki, S.; Brauer-Hartmann, D.; Bhayadia, R.; Alejo-Valle, O.; Issa, H.; Regenyi, E.; Beyer, C.; Labuhn, M.; Ihling, C.; Sinz, A.; Glass, M.; Huttelmaier, S.; Matzk, S.; Schmid, L.; Struwe, F. J.; Kadel, S.-K.; Reinhardt, D.; Yaspo, M.-L.; Heckl, D.; Klusmann, J.-H.
10.1101/2022.03.07.483334 — cancer biology — Posted on 2022-03-08
3114 Diversity of Learning to Control Complex Rehabilitation Robots Using High-Dimensional Interfaces
Lee, J. M.; Gebrekristos, T.; De Santis, D.; Nejati Javaremi, M.; Gopinath, D.; Parikh, B.; Mussa-Ivaldi, F. A.; Argall, B. D.
10.1101/2022.03.07.483341 — bioengineering — Posted on 2022-03-08
3119 LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways
Kshirsagar, A.; Gorelik, A.; Olender, T.; Sapir, T.; Tsuboi, D.; Rosenhek-Goldian, I.; Malitsky, S.; Itkin, M.; Argoetti, A.; Mandel-Gutfreund, Y.; Cohen, S. R.; Hanna, J. H.; Ulitsky, I.; Kaibuchi, K.; Reiner, O.
10.1101/2022.03.08.483407 — cell biology — Posted on 2022-03-08
3120 In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts
Cai, S.; Wu, Y.; Guillen-Samander, A.; Hancock-Cerutti, W. F.; Liu, J.; De Camilli, P.
10.1101/2022.03.08.482579 — cell biology — Posted on 2022-03-08
3121 New Microviridae isolated from Sulfitobacter reveals two cosmopolitan subfamilies of ssDNA phages infecting marine and terrestrial Alphaproteobacteria
Zucker, F.; Bischoff, V.; Olo Ndela, E.; Heyerhoff, B.; Poehlein, A.; Freese, H.; Roux, S.; Simon, M.; Enault, F.; Moraru, C.
10.1101/2022.03.08.483405 — microbiology — Posted on 2022-03-08
3122 Beer ethanol and iso-α-acid level affect microbial community establishment and beer chemistry throughout wood maturation of beer
Bossaert, S.; Kocijan, T.; Winne, V.; Schlich, J.; Herrera-Malaver, B.; Verstrepen, K. J.; Van Opstaele, F.; De Rouck, G.; Crauwels, S.; Lievens, B.
10.1101/2022.03.07.483260 — microbiology — Posted on 2022-03-08
3124 Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila
Park, A.; Croset, V.; Otto, N.; Agarwal, D.; Treiber, C. D.; Meschi, E.; Sims, D.; Waddell, S.
10.1101/2022.03.07.483255 — neuroscience — Posted on 2022-03-08
3125 Organ- and function-specific organization and bioelectronic modulation of vagus fascicles and fibers
jayaprakash, n.; Toth, V.; Song, W.; Vardhan, A.; Levy, T.; Tomaio, J.; Qanud, K.; Mughrabi, I.; Chang, Y.-C.; Rob, M.; Daytz, A.; Abbas, A.; Ashville, J.; Vikatos, A.; Ahmed, U.; Nassrallah, Z.; Volpe, B.; Tracey, K. J.; Al-Abed,, Y.; Datta-Chaudhuri, T.; Miller, L.; Barbe, M.; Lee, S.; Zanos, T.; Zanos, S.
10.1101/2022.03.07.483266 — neuroscience — Posted on 2022-03-08
3126 Circuit-Specific Targeting of Astrocytes for Genetic Control
Thompson, A.; Arano, R.; Ramos, K.; Kim, Y.; Li, Y.; Xu, W.
10.1101/2022.03.07.483355 — neuroscience — Posted on 2022-03-08
3127 A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila
Oikawa, I.; Kondo, S.; Hashimoto, K.; Kashiwabara, A.; Tanimoto, H.; Furukubo-Tokunaga, K.; Honjo, K.
10.1101/2022.03.08.483420 — neuroscience — Posted on 2022-03-08
3129 Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures
Dearborn, J. T.; Nelvagal, H. R.; Rensing, N. R.; Hughes, S. M.; Wishart, T. M.; Cooper, J. D.; Wong, M.; Sands, M. S.
10.1101/2022.03.07.483344 — neuroscience — Posted on 2022-03-08
3133 Molecular Dynamic Investigation of H5N1 Influenza Virus Dual H274Y-I222K Mutation Resistance to Peramivir
Buthelezi, N. M.; Mtambo, S. E.; Amoako, D. G.; Somboro, A. M.; Yakubu, E.; Khan, R. M.; Mhlongo, N. N.; Kumalo, H. M.
10.1101/2022.03.08.483396 — bioinformatics — Posted on 2022-03-08
3136 Demuxafy: Improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods
Neavin, D.; Senabouth, A.; Lee, J.; Ripoll, A.; Franke, L.; Prabhakar, S.; Ye, C.; McCarthy, D.; Mele, M.; Hemberg, M.; Powell, J.
10.1101/2022.03.07.483367 — genomics — Posted on 2022-03-08
3138 Impacts of recreational angling on fish population recovery after a commercial fishing ban
Dainys, J.; Jakubaviciute, E.; Gorfine, H.; Kirka, M.; Rakleviciute, A.; Morkvenas, A.; Putys, Z.; Lozys, L.; Audzijonyte, A.
10.1101/2022.03.07.483248 — ecology — Posted on 2022-03-08
3139 Flexible estimation of biodiversity with short-range multispectral imaging in a temperate grassland
Jackson, J.; Lawson, C. S.; Adelmant, C.; Huhtala, E.; Williamson, L.; Fernandes, P.; Hodgson, R.; King, H.; Maseyk, K.; Hawes, N.; Hector, A.; Salguero-Gomez, R.
10.1101/2022.03.08.483493 — ecology — Posted on 2022-03-08
3140 Parasite and pathogen prevalence in our closest animal companions is determined by accessibility of sanitation services
Chalkowski, K.; Lepczyk, C. A.; Wilson, A. E.; Valenta, K.; Sipley, B.; Brownlee, J.; Morgan, A. M.; Santos, S. R.; Willoughby, J. R.; Zohdy, S.
10.1101/2022.03.08.483406 — ecology — Posted on 2022-03-08
3141 The push-pull intercrop Desmodium does not repel, but intercepts and kills pests
Erdei, A. L.; David, A. B.; Savvidou, E. C.; Dzemedzionaite, V.; Chakravarthy, A.; Molnar, B. P.; Dekker, T.
10.1101/2022.03.08.482778 — ecology — Posted on 2022-03-08
3142 Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of function in pancreatic islet beta cells
Rodrigues dos Santos, K.; Roy, G.; Binns, D. D.; Grzemska, M. G.; Barella, L. F.; Armoo, F.; McCoy, M. K.; Huynh, A. V.; Yang, J. Z.; Posner, B. A.; Cobb, M. H.; Kalwat, M. A.
10.1101/2022.03.07.482881 — cell biology — Posted on 2022-03-08
3143 Cell Surface-Bound La Protein Regulates The Cell Fusion Stage Of Osteoclastogenesis
Whitlock, J. M.; Leikina, E.; Melikov, K.; Fernandez De Castro, L.; Mattijssen, S.; Maraia, R.; Collins, M.; Chernomordik, L.
10.1101/2022.03.08.479741 — cell biology — Posted on 2022-03-08
3144 A versatile pattern-forming cortical circuit based on Rho, F-actin, Ect2 and RGA-3/4
Michaud, A.; Leda, M.; Swider, Z. T.; Kim, S.; He, J.; Landino, J.; Valley, J. R.; Huisken, J.; Goryachev, A. B.; von Dassow, G.; Bement, W.
10.1101/2022.03.08.483353 — cell biology — Posted on 2022-03-08
3151 Thyroid hormone induces B cells abnormal differentiation via overexpression of B cell-activating factor
Liu, S.; Li, G.-Q.; Gu, Q.-W.; Wang, J.; Cao, X.; Zhong, Y.; Miao, J.-J.; Sun, Q.; Gu, W.-S.; Mao, X.-M.
10.1101/2022.03.07.483380 — immunology — Posted on 2022-03-08
3152 Locus coeruleus neuromelanin predicts ease of attaining and maintaining neural states of arousal
Hussain, S.; Menchaca, I.; Shalchy, M. A.; Yaghoubi, K.; langley, j.; Seitz, A.; Hu, X.; Peters, M. A. K.
10.1101/2022.03.07.483289 — neuroscience — Posted on 2022-03-08
3153 Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization
Trindade, P.; Nascimento, J. M.; Casas, B. S.; Faundez, T. M.; Gasparotto, J.; Ribeiro, C. T.; Devalle, S.; Sauma, D.; Moreira, J. C. F.; Gelain, D. P.; Porciuncula, L. O.; Palma, V.; Martins-de-Souza, D.; Rehen, S. K.
10.1101/2022.03.07.483024 — neuroscience — Posted on 2022-03-08
3156 The ZuCo Benchmark on Cross-Subject Reading Task Classification with EEG and Eye-Tracking Data
Hollenstein, N.; Tröndle, M.; Plomecka, M.; Kiegeland, S.; Özyurt, Y.; Jäger, L. A.; Langer, N.
10.1101/2022.03.08.483414 — neuroscience — Posted on 2022-03-08
3157 Comparative metaproteomics demonstrates different views on the complex granular sludge microbiome
Kleikamp, H. B. C.; Grouzdev, D.; Schaasberg, P.; van Valderen, R.; van der Zwaan, R.; van de Wijgaart, R.; Lin, Y.; Abbas, B.; Pronk, M.; van Loosdrecht, M. C. M.; Pabst, M.
10.1101/2022.03.07.483319 — systems biology — Posted on 2022-03-08
3160 TOR mediates cytokinin-driven development and defense cues
Marash, I.; Gupta, R.; Leibman-Markus, M.; Avni, A.; Bar, M.
10.1101/2022.03.07.483332 — plant biology — Posted on 2022-03-08
3161 Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy - a focus on energy expenditure
Stefanidis, A.; Lee, C. M.; Greaves, E.; Montgomery, M.; Arnold, M.; Newn, S.; Budin, A.; Foldi, C. J.; Burton, P. R.; Brown, W. A.; Lutz, T. A.; Watt, M. J.; Oldfield, B. J.
10.1101/2022.03.07.482714 — physiology — Posted on 2022-03-08
3162 The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma
Alban, T.; Grabowski, M. M.; Otvos, B.; Watson, D. B.; Zalavadia, A.; Makarav, V.; Troike, K. M.; McGraw, M.; Rabljenovic, A.; Lauko, A.; Neumann, C. K. A.; Roversi, G.; Waite, K.; Cioffi, G.; Patil, N.; Tran, T.; McCortney, K.; Steffens, A.; Diaz, M.; Brown, J. M.; Egan, K.; Horbinski, C.; Barnholtz-sloan, J.; Vogelbaum, M.; Bucala, R.; Chan, T.; Ahluwalia, M.; Lathia, J.
10.1101/2022.03.07.483365 — cancer biology — Posted on 2022-03-08
3163 Protease Activity Analysis: A Toolkit for Analyzing Enzyme Activity Data
Soleimany, A. P.; Martin Alonso, C.; Anahtar, M. N.; Wang, C. S.; Bhatia, S. N.
10.1101/2022.03.07.483375 — bioinformatics — Posted on 2022-03-08
3168 A global pangenome for the wheat fungal pathogen Pyrenophora tritici-repentis and prediction of effector protein structural homology
Moolhuijzen, P. M.; See, P. T.; Shi, G.; Powell, H. R.; Cockram, J.; Jorgensen, L. N.; Benslimane, H.; Strelkov, S. E.; Turner, J.; Liu, Z.; Moffat, C. S.
10.1101/2022.03.07.482416 — genomics — Posted on 2022-03-08
3169 Dissecting the Pyrenophora tritici-repentis (tan spot of wheat) pangenome
Gourlie, R.; McDonald, M.; Hafez, M.; Ortega-Polo, R.; Low, K. E.; Abbott, D. W.; Strelkov, S.; Daayf, F.; Aboukhaddour, R.
10.1101/2022.03.07.483352 — genomics — Posted on 2022-03-08
3174 Rapid identification of mosquito species, sex and age by mass spectrometric analysis
Wagner, I.; Grigoraki, L.; Enevoldsen, P.; Clarkson, M.; Jones, S.; Hurst, J. L.; Beynon, R. J.; Ranson, H.
10.1101/2022.03.07.483241 — ecology — Posted on 2022-03-08
3175 Fish microbiomes 101: disentangling the rules governing marine fish mucosal microbiomes across 101 species
Minich, J. J.; Harer, A.; Vechinski, J.; Frable, B. W.; Skelton, Z.; Kunselman, E.; Shane, M.; Perry, D.; Gonzalez, A.; McDonald, D.; Knight, R.; Michael, T. P.; Allen, E. E.
10.1101/2022.03.07.483203 — ecology — Posted on 2022-03-08
3176 Resource use differences of two coexisting chironomid species at localized scales
McCormick, A. R.; Phillips, J. S.; Botsch, J. C.; Olafsson, J. S.; Ives, A. R.
10.1101/2022.03.07.483209 — ecology — Posted on 2022-03-08
3177 Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality
Wattrus, S. J.; Smith, M. L.; Pessoa Rodrigues, C.; Hagedorn, E. J.; Budnik, B.; Zon, L. I.
10.1101/2022.03.07.483327 — developmental biology — Posted on 2022-03-08
3183 Species-specific cutaneous protein signatures upon incision injury and correlation with distinct pain-related phenotypes in humans
Segelcke, D.; van der Burgt, M.; Kappert, C.; Schmidt-Garcia, D.; Sondermann, J. R.; Bigalke, S.; Pradier, B.; Gomez-Varela, D.; Zahn, P. K.; Schmidt, M.; Pogatzki-Zahn, E. M.
10.1101/2022.03.07.482980 — neuroscience — Posted on 2022-03-08
3186 PP2A phosphatase regulates cell-type specific cytoskeletal organization to drive dendritic diversification
Bhattacharjee, S.; Lottes, E. N.; Nanda, S.; Golshir, A.; Patel, A. A.; Ascoli, G. A.; Cox, D. N.
10.1101/2022.03.07.483285 — neuroscience — Posted on 2022-03-08
3188 Belgian endive-derived biostimulants promote shoot and root growth in vitro.
Ogunsanya, H. Y.; Motti, P.; Li, J.; Trinh, H. K.; Xu, L.; Bernaert, N.; Van Droogenbroeck, B.; Murvanidze, N.; Werbrouck, S.; Mangelinckx, S.; Ramirez, A.; Geelen, D.
10.1101/2022.03.07.481290 — plant biology — Posted on 2022-03-08
3189 Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model
Atanasova, V. S.; Cardona, C. d. J.; Hejret, V.; Tiefenbacher, A.; Tran, L.; Binder, C.; Mair, T.; Kabiljo, J.; Clement, J.; Woeran, K.; Neudert, B.; Hengstschlaeger, M.; Mitterhauser, M.; Muellauer, L.; Tichy, B.; Bergmann, M.; Schweikert, G.; Hartl, M.; Dolznig, H.; Egger, G.
10.1101/2022.03.07.483214 — cancer biology — Posted on 2022-03-08
3191 Integrative analysis to identify shared mechanisms between schizophrenia and bipolar disorder and their comorbidities
Bharadhwaj, V.; Mubeen, S.; Sargsyan, A.; Mariya Jose, G.; Geissler, S.; Hofmann-Apitius, M.; Domingo-Fernandez, D.; Tom Kodamullil, A.
10.1101/2022.03.07.483233 — bioinformatics — Posted on 2022-03-08
3200 The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK
Hill, V.; du Plessis, L.; Peacock, T. P. A.; Aggarwal, D.; Carabelli, A.; Colquhoun, R.; Ellaby, N.; Gallagher, E.; Groves, N.; Jackson, B.; McCrone, J.; O'Toole, A. N.; Price, A.; Sanderson, T.; Scher, E.; Southgate, J. A.; Volz, E.; The COVID-19 genomics UK (COG-UK) consortium, ; Barclay, W. S.; Barrett, J.; Chand, M.; Connor, T. R.; Goodfellow, I. G.; Gupta, R. K.; Harrison, E.; Loman, N.; Myers, R.; Robertson, D. L.; Pybus, O.; Rambaut, A.
10.1101/2022.03.08.481609 — evolutionary biology — Posted on 2022-03-08
3202 Biodiversity effects on seedling biomass growth are modulated by light environment across functional groups
Anujan, K.; Shabnam, A.; Ali, I.; Kumar, G. A.; Sankaran, M.; Krishnadas, M.; Naeem, S.
10.1101/2022.03.08.483461 — ecology — Posted on 2022-03-08
3203 Integrated analysis of Wnt signalling system component gene expression
Murphy, P.; Armit, C.; Hill, B.; Venkataraman, S.; Frankel, P.; Baldock, R. A.; Davidson, D. R.
10.1101/2022.03.07.483288 — developmental biology — Posted on 2022-03-08
3205 Excitatory and inhibitory D-serine binding to the NMDA receptor
Yovanno, R. A.; Chou, T. H.; Brantley, S. J.; Furukawa, H.; Lau, A. Y.
10.1101/2022.03.07.483247 — biophysics — Posted on 2022-03-08
3207 Tourmaline: a containerized workflow for rapid and iterable amplicon sequence analysis using QIIME 2 and Snakemake
Thompson, L. R.; Anderson, S. R.; Den Uyl, P. A.; Patin, N. V.; Lim, S. J.; Sanderson, G.; Goodwin, K. D.
10.1101/2021.09.15.460495 — bioinformatics — Posted on 2022-03-08
3209 Transient accumulation and bidirectional movement of KIF13B in primary cilia
Juhl, A. D.; Anvarian, Z.; Kuhns, S.; Berges, J.; Andersen, J. S.; Wustner, D.; Pedersen, L. B.
10.1101/2021.07.09.451768 — cell biology — Posted on 2022-03-08
3210 Human repair-related Schwann cells adopt functions of antigen-presenting cells in vitro
Berner, J.; Weiss, T.; Sorger, H.; Rifatbegovic, F.; Kauer, M.; Windhager, R.; Dohnal, A.; Ambros, P. F.; Ambros, I. M.; Steinberger, P.; Taschner-Mandl, S.
10.1101/2022.03.07.483322 — cell biology — Posted on 2022-03-08
3211 A comparison of six DNA extraction protocols for 16S, ITS, and shotgun metagenomic sequencing of microbial communities
Shaffer, J. P.; Carpenter, C. S.; Martino, C. P.; Salido, R. A.; Bryant, M.; Sanders, K.; Schwartz, T.; Humphrey, G.; Swafford, A. D.; Knight, R.
10.1101/2022.03.07.483343 — microbiology — Posted on 2022-03-08
3212 Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate
McCorvie, T. J.; Loria, P. M.; Tu, M.; Han, S.; Shrestha, L.; Froese, D. S.; Ferreira, I. M.; Berg, A. P.; Yue, W. W.
10.1101/2021.11.12.468446 — biochemistry — Posted on 2022-03-08
3217 CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation
Carrasco, K.; Montersino, C.; Derviaux, C.; Saez-Ayala, M.; Hoffer, L.; Restouin, A.; Castellano, R.; Casassa, J.; Roche, P.; Pasquier, E.; Combes, S.; Morelli, X.; Collette, Y.; Betzi, S.
10.1101/2021.12.13.472388 — cancer biology — Posted on 2022-03-08
3218 Surface interaction patches link non-specific binding and phase separation of antibodies
Ausserwöger, H.; Krainer, G.; Welsh, T. J.; Sneideris, T.; Schneider, M. M.; Invernizzi, G.; Herling, T. W.; Lorenzen, N.; Knowles, T. P. J.
10.1101/2022.03.07.483238 — biophysics — Posted on 2022-03-08
3219 Information-theoretic clustering for single-cell transcriptomics
Casey, M. J.; Fliege, J.; Sanchez-Garcia, R. J.; MacArthur, B. D.
10.1101/2020.10.01.322255 — bioinformatics — Posted on 2022-03-08
3220 A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution
Grau-Bove, X.; Navarrete, C.; Chiva, C.; Pribasnig, T.; Anto, M.; Torruella, G.; Galindo, L. J.; Lang, B. F.; Moreira, D.; Lopez-Garcia, P.; Ruiz-Trillo, I.; Schleper, C.; Sabido, E.; Sebe-Pedros, A.
10.1101/2021.11.30.470311 — evolutionary biology — Posted on 2022-03-08
3221 Low heritability and high phenotypic plasticity of salivary cortisol in response to environmental heterogeneity in a wild pinniped
Nagel, R.; Kaiser, S.; Stainfield, C.; Toscani, C.; Fox-Clarke, C.; Paijmans, A. J.; Costa Castro, C.; Vendrami, D. J.; Forcada, J.; Hoffman, J. I.
10.1101/2021.10.08.463664 — ecology — Posted on 2022-03-08
3222 Intra-membrane client recognition potentiates the chaperone functions of Calnexin
Bloemeke, N.; Meighen-Berger, K.; Hitzenberger, M.; Bach, N. C.; Parr, M.; Coelho, J. P. L.; Frishman, D.; Zacharias, M.; Sieber, S.; Feige, M. J.
10.1101/2022.03.07.483232 — cell biology — Posted on 2022-03-08
3224 Characterization of Cysteine-rich protein families of Giardia lamblia and their role during antigenic variation.
Rodriguez-Walker, M.; Molina, C. R.; Lujan, L. A.; Saura, A.; Baronetto, V. M.; Jerlström-Hultqvist, J.; Svärd, S. G.; Fernandez, E. A.; Lujan, H. D.
10.1101/2022.03.07.483299 — microbiology — Posted on 2022-03-08
3226 Anti-spike antibody response to natural infection with SARS-CoV-2 and its activity against emerging variants
Chen, C.-P.; Huang, K.-Y. A.; Shih, S.-R.; Lin, Y.-C.; Cheng, C.-Y.; Huang, Y.-C.; Lin, T.-Y.; Cheng, S.-H.
10.1101/2022.03.07.481737 — immunology — Posted on 2022-03-08
3230 Erbb4 deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypes
Kiemes, A.; Serrano Navacerrada, M. E.; Kim, E.; Randall, K.; Simmons, C.; Rojo Gonzales, L.; Petrinovic, M.-M.; Lythgoe, D.; Rotaru, D.; Di Censo, D.; Hirschler, L.; Barbier, E.; Vernon, A. C.; Stone, J. M.; Davies, C.; Cash, D.; Modinos, G.
10.1101/2022.03.07.483347 — neuroscience — Posted on 2022-03-08
3231 The transcription factor network of E. coli steers global responses to shifts in RNAP concentration
Lima de Brito Almeida, B.; Bahrudeen, M. N. M.; Chauhan, V.; Dash, S.; Kandavalli, V.; Hakkinen, A.; Lloyd-Price, J.; Palma, C. S. D.; Baptista, I. S. C.; Gupta, A.; Kesseli, J.; Dufour, E.; Smolander, O.-P.; Nykter, M.; Auvinen, P.; Jacobs, H. T.; Oliveira, S. M. D.; Ribeiro, A. S.
10.1101/2022.03.07.483226 — systems biology — Posted on 2022-03-08
3236 Skeletal Muscle Proteostasis Promotes Central Nervous System Rejuvenation and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Matthews, I.; Birnbaum, A.; Gromova, A.; Coutinho, K.; McGraw, M.; Patterson, D.; Banks, M. T.; Nobles, A.; Miranda, H. C.; La Spada, A. R.; Cortes, C. J.
10.1101/2022.03.07.482891 — neuroscience — Posted on 2022-03-08
3237 Automated reconstruction of dendritic and axonal arbors reveals molecular correlates of neuroanatomy
Gliko, O.; Mallory, M.; Dalley, R.; Gala, R.; Gornet, J.; Zeng, H.; Sorensen, S.; Sumbul, U.
10.1101/2022.03.07.482900 — neuroscience — Posted on 2022-03-08
3239 Rec8 cohesin-mediated axis-loop chromatin architecture is required for meiotic recombination
Sakuno, T.; Tashiro, S.; Tanizawa, H.; Iwasaki, O.; Ding, D.-Q.; Haraguchi, T.; Noma, K.-i.; Hiraoka, Y.
10.1101/2021.12.09.472021 — cell biology — Posted on 2022-03-07
3242 Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Herbst, S. A.; Vesterlund, M.; Helmboldt, A. J.; Jafari, R.; Siavelis, I.; Stahl, M.; Schitter, E.; Liebers, N.; Brinkmann, B.; Czernilofsky, F.; Roider, T.; Bruch, P.-M.; Iskar, M.; Kittai, A.; Huang, Y.; Lu, J.; Richter, S.; Mermelekas, G.; Umer, H. M.; Knoll, M.; Kolb, C.; Lenze, A.; Cao, X.; Oesterholm, C.; Wahnschaffe, L.; Herling, C.; Scheinost, S.; Ganzinger, M.; Mansouri, L.; Kriegsmann, K.; Kriegsmann, M.; Anders, S.; Zapatka, M.; Del Poeta, G.; Zucchetto, A.; Bomben, R.; Gattei, V.; Dreger, P.; Woyach, J.; Herling, M.; Mueller-Tidow, C.; Rosenquist, R.; Stilgenbauer, S.; Zenz, T.; Hu
10.1101/2022.03.01.481539 — cancer biology — Posted on 2022-03-07
3243 A Proteome-Wide Map of Chaperone-Assisted Protein Refolding in the Cytosol
To, P.; Lee, S. O.; Xia, Y.; Devlin, T.; Fleming, K. G.; Fried, S. D.
10.1101/2021.11.20.469408 — biophysics — Posted on 2022-03-07
3247 Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A
Zhang, C.; Fang, T.; Wang, X.; Shi, L.; Zhan, B.; Hou, N.; Liu, S.; Bao, M.; Chi, G.
10.1101/2022.03.07.483358 — microbiology — Posted on 2022-03-07
3252 Incomplete bunyavirus particles contribute to within-host spread and between-host transmission
Bermudez-Mendez, E.; Bronsvoort, K. F.; Zwart, M. P.; van de Water, S.; Cardenas-Rey, I.; Vloet, R. P. M.; Koenraadt, C. J. M.; Pijlman, G. P.; Kortekaas, J.; Schreur, P. J. W.
10.1101/2022.03.07.483181 — microbiology — Posted on 2022-03-07
3253 Global phylogeography of marine Synechococcus in coastal areas reveals strikingly different communities than in the open ocean
Dore, H.; Leconte, J.; Guyet, U.; Breton, S.; Farrant, G. K.; Demory, D.; Ratin, M.; Hoebeke, M.; Corre, E.; Pitt, F. D.; Ostrowski, M.; Scanlan, D. J.; Partensky, F.; Six, C.; Garczarek, L.
10.1101/2022.03.07.483242 — microbiology — Posted on 2022-03-07
3256 Dynamic Sex Differences in Reactive and Appetitive Aggression
Aubry, A.; Burnett, C. J.; Goodwin, N.; Li, L.; Navarrete, J.; Zhang, Y.; Tsai, V.; Durand-de Cuttoli, R.; Golden, S.; Russo, S.
10.1101/2022.02.22.481480 — neuroscience — Posted on 2022-03-07
3258 The mechanical regulation of RNA binding protein hnRNPC in the failing heart
Martino, F.; Varadarajan, N. M.; Perestrelo, A. R.; Hejret, V.; Durikova, H.; Horvath, V.; Cavalieri, F.; Caruso, F.; Albihlal, W. S.; Gerber, A. P.; O'Connell, M. A.; Vanacova, S.; Pagliari, S.; Forte, G.
10.1101/2021.08.27.457906 — pathology — Posted on 2022-03-07
3259 The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells in vitro.
Fatima, N.; Shen, Y.; Crassini, K.; Iwanowicz, E.; Lang, H.; Karanewsky, D.; Christopherson, R.; Mulligan, S.; Best, G.
10.1101/2022.03.07.483345 — cancer biology — Posted on 2022-03-07
3260 A comprehensive analysis of immune landscape of Indian triple negative breast cancer
Korlimarla, A.; PS, H.; Prabhu, J.; Ragulan, C.; Patil, Y.; VP, S.; Desai, K.; Mathew, A.; Appachu, S.; Diwakar, R.; BS, S.; Cheang, M.; Sadanandam, A.
10.1101/2022.03.06.483159 — cancer biology — Posted on 2022-03-07
3261 Surface interaction patches link non-specific binding and phase separation of antibodies
Ausserwöger, H.; Krainer, G.; Welsh, T. J.; Sneideris, T.; Schneider, M. M.; Invernizzi, G.; Herling, T. W.; Lorenzen, N.; Knowles, T. P. J.
10.1101/2022.03.07.483238 — biophysics — Posted on 2022-03-07
3262 Nuclear lamina strain states revealed by intermolecular force biosensor
Danielsson, B. E.; Abraham, B. G.; Mantyla, E.; Cabe, J. I.; Mayer, C. R.; Rekonen, A.; Ek, F.; Conway, D. E.; Ihalainen, T. O.
10.1101/2022.03.07.483300 — biophysics — Posted on 2022-03-07
3265 An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling
Gonzalez-Perez, D.; Das, S.; Medina, E.; Antfolk, D.; Egan, E. D.; Blacklow, S. C.; Rodriguez, P. C.; Luca, V. C.
10.1101/2022.03.07.483330 — bioengineering — Posted on 2022-03-07
3266 A short ERAP2 that binds IRAP is expressed in macrophages independently from gene variation
Mattorre, B.; Caristi, S.; Donato, S.; Volpe, E.; Faiella, M.; Paiardini, A.; Sorrentino, R.; Paladini, F.
10.1101/2022.03.07.483178 — biochemistry — Posted on 2022-03-07
3267 Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump
Kowalski, A.; Betzer, C.; Larsen, S. T.; Gregersen, E.; Newcombe, E. A.; Bermejo, M. C.; Langkilde, A. E.; Kragelund, B. B.; Jensen, P. H.; Nissen, P.
10.1101/2022.02.21.481193 — biochemistry — Posted on 2022-03-07
3269 Promising Antimalarials targeting Apicoplast DNA Polymerase from Plasmodium falciparum
Cheda, P.; Nieto, N.; Kaur, S.; Beck, J. M.; Beck, J. R.; Kerns, R.; Honzatko, R. B.; Nelson, S. W.
10.1101/2022.03.07.483284 — biochemistry — Posted on 2022-03-07
3270 Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
Correia-Melo, C.; Kamrad, S.; Messner, C. B.; Tengolics, R.; Herrera-Dominguez, L.; Townsend, S.; Alam, M. T.; Freiwald, A.; Campbell, K.; Aulakh, S.; Szyrwiel, L.; Yu, J. S. L.; Zelezniak, A.; Demichev, V.; Muelleder, M.; Papp, B.; Ralser, M.
10.1101/2022.03.07.483228 — biochemistry — Posted on 2022-03-07
3271 Deficits in seizure threshold and other behaviors in adult mice without gross neuroanatomic injury after late gestation transient prenatal hypoxia
Cristancho, A. G.; Gadra, E. C.; Samba, I. M.; Zhao, C.; Ouyang, M.; Magnitsky, S.; Huang, H.; Viaene, A. N.; Anderson, S. A.; Marsh, E. D.
10.1101/2021.08.04.451528 — animal behavior and cognition — Posted on 2022-03-07
3272 Genetic Dissection of the RNA Polymerase II Transcription Cycle
Chou, S.-P.; Alexander, A. K.; Rice, E. J.; Choate, L. A.; Cohen, P. E.; Danko, C. G.
10.1101/2021.05.23.445279 — genomics — Posted on 2022-03-07
3278 Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal-end
Aydogan, M. G.; Hankins, L. E.; Steinacker, T. L.; Mofatteh, M.; Saurya, S.; Wainman, A.; Wong, S.-S.; Lu, X.; Zhou, F. Y.; Raff, J. W.
10.1101/2021.07.08.451650 — cell biology — Posted on 2022-03-07
3279 Realtime morphological characterization and sorting of unlabeled viable cells using deep learning
Salek, M.; Li, N.; Chou, H.-P.; Saini, K.; Jovic, A.; Jacobs, K. B.; Johnson, C.; Lee, E. J.; Chang, C.; Nguyen, P.; Mei, J.; Pant, K. P.; Wong-Thai, A. Y.; Smith, Q. F.; Huang, S.; Chow, R.; Cruz, J.; Walker, J.; Chan, B.; Musci, T. J.; Ashley, E. A.; Masaeli, M.
10.1101/2022.02.28.482368 — cell biology — Posted on 2022-03-07
3280 Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture
Ergir, E.; Oliver-de la Cruz, J.; Fernandes, S.; Cassani, M.; Niro, F.; Sousa, D.; Vrbsky, J.; Vinarsky, V.; Perestrelo, A. R.; Debellis, D.; Cavalieri, F.; Pagliari, S.; Redl, H.; Ertl, P.; Forte, G.
10.1101/2022.03.07.483273 — cell biology — Posted on 2022-03-07
3281 Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase
huang, h.; Li, Z.; Yang, X.; Ding, Z.; Peng, L.; Song, Q.; Cui, F.; Zhang, D.; Xia, C.; Li, K.; Yin, H.; Li, S.
10.1101/2022.03.07.483351 — cell biology — Posted on 2022-03-07
3282 Structural basis of Ty1 integrase tethering on RNA polymerase III for targeted DNA integration
Nguyen, P. Q.; Huecas, S.; Asif-Laidin, A.; Plaza-Pegueroles, A.; Palmic, N.; Acker, J.; Reguera, J.; Lesage, P.; Fernandez-Tornero, C.
10.1101/2022.03.07.483246 — molecular biology — Posted on 2022-03-07
3283 SUMO conjugation regulates the activity of the Integrator complex
Bragado, L.; Magalnik, M.; Mammi, P.; Romero, A.; Gaioli, N.; Pozzi, B.; Srebrow, A.
10.1101/2022.03.07.483123 — molecular biology — Posted on 2022-03-07
3285 Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities
Afrizal, A.; Jennings, S. A. V.; Hitch, T. C. A.; Riedel, T.; Basic, M.; Panyot, A.; Treichel, N.; Hager, F. T.; Brueck, R.; Wong, E. O.-Y.; von Strempel, A.; Eberl, C.; Buhl, E. M.; Abt, B.; Bleich, A.; Tolba, R.; Navarre, W. W.; Kiessling, F.; Horz, H.-P.; Torow, N.; Cerovic, V.; Stecher, B.; Strowig, T.; Overmann, J.; Clavel, T.
10.1101/2022.03.07.483007 — microbiology — Posted on 2022-03-07
3289 Low memory T cells blood counts and high naive regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosis
Canto-Gomes, J.; S. Silva, C.; Rb-Silva, R.; Boleixa, D.; Silva, A. M. d.; Cheynier, R.; Costa, P.; Gonzalez-Suarez, I.; Correia-Neves, M.; Cerqueira, J.; Nobrega, C.
10.1101/2022.03.07.483243 — immunology — Posted on 2022-03-07
3290 RIM and RIM-binding protein localize synaptic Cav2 channels to differentially regulate transmission in neuronal circuits
Janosi, B.; Liewald, J. F.; Yu, S.-c.; Umbach, S.; Alcantara, I. C.; Bergs, A. C.; Schneider, M. W.; Shao, J.; Gottschalk, A.
10.1101/2021.02.01.429206 — neuroscience — Posted on 2022-03-07
3291 Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms
Chen, X.; Calandrelli, R.; Girardini, J.; Yan, Z.; Tan, Z.; Xu, X.; Hiniker, A.; Zhong, S.
10.1101/2022.02.15.480384 — neuroscience — Posted on 2022-03-07
3296 The glycocalyx affects the mechanotransductive perception of the topographical microenvironment
Chighizola, M.; Dini, T.; Marcotti, S.; D'Urso, M.; Piazzoni, C.; Borghi, F.; Previdi, A.; Ceriani, L.; Folliero, C.; Stramer, B.; Lenardi, C.; Milani, P.; Podestà, A.; Schulte, C.
10.1101/2021.03.02.433591 — biophysics — Posted on 2022-03-07
3297 Angiotensin converting enzyme 2 (ACE2): Virus accomplice or host defender
Wang, J.; Chang, H.; Qiao, Y.; Sun, H.; Li, X.; Yuan, S.; Zhang, S.; Shan, C.
10.1101/2022.03.06.483197 — bioinformatics — Posted on 2022-03-07
3299 SARS-CoV-2 Spike evolution influences GBP and IFITM sensitivity
Mesner, D.; Reuschl, A.-K.; Whelan, M. V. X.; Bronzovich, T.; Haider, T.; Thorne, L. G.; Towers, G. J.; Jolly, C.
10.1101/2022.03.07.481785 — microbiology — Posted on 2022-03-07
3300 Canine saliva is a source of interspecies antimicrobial resistance gene transfer
Toth, A. G.; Toth, I.; Rozsa, B.; Kovacs, E. G.; Dubecz, A.; Patai, A. V.; Nemeth, T.; Kaplan, S.; Makrai, L.; Solymosi, N.
10.1101/2022.03.07.483304 — genomics — Posted on 2022-03-07
3301 Proteomic Profiling of Hypoplastic Lungs Suggests an Underlying Inflammatory Response in the Pathogenesis of Abnormal Lung Development in Congenital Diaphragmatic Hernia
Wagner, R.; Lieckfeldt, P.; Piyadasa, H.; Markel, M.; Riedel, J.; Stefanovici, C.; Peukert, N.; Patel, D.; Derraugh, G.; Min, S. L.; Gosemann, J. H.; Pascoe, C. D.; Tse, A.; Lacher, M.; Mookherjee, N.; Keijzer, R.
10.1101/2022.03.07.483298 — developmental biology — Posted on 2022-03-07
3303 Alterations of the axon initial segment in multiple sclerosis
Senol, A. D.; Pinto, G.; Beau, M.; Guillemot, V.; Dupree, J. L.; Stadelmann, C.; Ranft, J.; Lubetzki, C.; Davenne, M.
10.1101/2022.03.07.483302 — neuroscience — Posted on 2022-03-07
3304 CF-Seq, An Accessible Web Application for Rapid Re-Analysis of Cystic Fibrosis Pathogen RNA Sequencing Studies
Neff, S. L.; Hampton, T. H.; Puerner, C.; Cengher, L.; Doing, G.; Lee, A. J.; Koeppen, K.; Cheung, A. L.; Hogan, D. A.; Cramer, R. A.; Stanton, B. A.
10.1101/2022.03.07.483313 — bioinformatics — Posted on 2022-03-07
3310 Comparing lipid remodeling in mouse adipose and liver tissue with quantitative Raman microscopy
Paul, A.; Chanclon, B.; Brännmark, C.; Wittung-Stafshede, P.; Olofsson, C. S.; Asterholm, I. W.; Parekh, S. H.
10.1101/2022.03.07.483297 — cell biology — Posted on 2022-03-07
3313 Targeting neuronal homeostasis to prevent seizures
Mulroe, F.; Lin, W.-H.; Mackenzie-Gray-Scott, C.; Aourz, N.; Fan, Y. N.; Coutts, G.; Parrish, R. R.; Smolders, I.; Trevelyan, A.; Wykes, R.; Allan, S. M.; Freeman, S.; Baines, R. A.
10.1101/2022.03.07.483229 — neuroscience — Posted on 2022-03-07
3314 Anti-phasic oscillatory development for speech and noise processing in cochlear implanted toddlers
Wu, M.; Wang, Y.; Zhao, X.; Xin, T.; Wu, K.; Liu, H.; Wu, S.; Lin, M.; Chai, X.; Li, J.; Zhu, C.; Wei, C.; Liu, Y.; Zhang, Y.-X.
10.1101/2022.03.07.483211 — neuroscience — Posted on 2022-03-07
3317 Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice.
Morozova, M.; Borisova, M.; Snytnikova, O.; Achasova, K.; Litvinova, E.; Tsentalovich, Y.; Kozhevnikova, E.
10.1101/2022.03.07.483210 — animal behavior and cognition — Posted on 2022-03-07
3318 Genetic heritage of the BaPhuthi highlights an over ethnicised notion of 'Bushman' in the Maloti-Drakensberg, Southern Africa
Daniels, R. J.; D'Amato, M. E.; Lesaoana, M.; Kasu, M.; Ehlers, K.; Chauke, P. A.; Lecheko, P.; Challis, S.; Rockett, K.; Montinaro, F.; Gonzalez-Santos, M.; Capelli, C.
10.1101/2022.03.05.483114 — genomics — Posted on 2022-03-07
3320 Anthroponumbers.org: A Quantitative Database Of Human Impacts on Planet Earth
Chure, G.; Banks, R. A.; Flamholz, A. I.; Sarai, N. S.; Kamb, M.; Lopez-Gomez, I.; Bar-On, Y.; Milo, R.; Phillips, R.
10.1101/2022.03.04.483053 — ecology — Posted on 2022-03-07
3324 Morphofunctional changes at the active zone during synaptic vesicle exocytosis
Radecke, J.; Seeger, R.; Kadkova, A.; Laugks, U.; Khosrozadeh, A.; Goldie, K. N.; Lucic, V.; Sorensen, J. B.; Zuber, B.
10.1101/2022.03.07.483217 — neuroscience — Posted on 2022-03-07
3325 Cetacean "gas-bubble thromboembolic polycystic liver disease": "Budd-Chiari-like syndrome" in dolphins?
Fernandez, A.; Jepson, P. D.; Diaz Delgado, J.; Bernaldo de Quiros, Y.; Sierra, E.; Mompeo, B.; Vela, A. I.; Di Guardo, G.; Suarez-Santana, C.; Espinosa de los Monteros, A.; Herraez, P.; Andrada, M.; Caballero, M. J.; Rivero, M.; Consoli, F.; Castro, A.; Quesada-Canales, O.; Arbelo, M.
10.1101/2022.03.05.483097 — pathology — Posted on 2022-03-07
3326 SARS-CoV-2 triggers Golgi fragmentation via downregulation of GRASP55 to facilitate viral trafficking
Zhang, J.; Kennedy, A.; Xing, L.; Bui, S.; Reid, W.; Joppich, J.; Ahat, E.; Rose, M.; Tang, Q.; Tai, A. W.; Wang, Y.
10.1101/2022.03.04.483074 — cell biology — Posted on 2022-03-07
3329 mRNA-based vaccine candidate COReNAPCIN(R) induces robust humoral and cellular immunity in mice and non-human primates
Alimohammadi, R.; Porgoo, M.; Eftekhary, M.; Kiaie, S. H.; Ansari Dezfouli, E.; Dehghani, M.; Nasrollah, K.; Malekshahab, T.; Heidari, M.; Pouya, S.; Alimohammadi, M.; Sattari Khavas, D.; Modaresi, M. S.; Ghasemi, M. H.; Ramyar, H.; Mohammadipour, F.; Hamzelouei, F.; Mofayezi, A.; Mottaghi, S. S.; Rahmati, A.; Razzaznian, M.; Tirandazi, V.; Borzouee, F.; Sadeghi, H.; Haji Mohammadi, M.; Rastegar, L.; Safar Sajadi, S. M.; Ehsanbakhsh, H.; Bazmbar, H.; Shams Nouraee, M.; Pazooki, P.; Pahlevan Neshan, M.; Alishah, K.; Nasiri, F.; Mokhberian, N.; Mohammadi, S. S.; Akar, S.; Niknam, H.; Azizi, M.;
10.1101/2022.03.05.483092 — immunology — Posted on 2022-03-07
3330 Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease
Zhou, P.; Song, G.; He, W.-t.; Beutler, N.; Tse, L. V.; Martinez, D. R.; Schafer, A.; Anzanello, F.; Yong, P.; Peng, L.; Dueker, K.; Musharrafieh, R.; Callaghan, S.; Capozzola, T.; Yuan, M.; Liu, H.; Limbo, O.; Parren, M.; Garcia, E.; Rawlings, S. A.; Smith, D. M.; Nemazee, D.; Jardine, J. G.; Wilson, I. A.; Safonova, Y.; Rogers, T.; Baric, R. S.; Gralinski, L. E.; Burton, D. R.; Andrabi, R.
10.1101/2022.03.04.479488 — immunology — Posted on 2022-03-07
3331 Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody
Piepenbrink, M. S.; Park, J.-G.; Deshpande, A.; Loos, A.; Ye, C.; Basu, M.; Sarkar, S.; Chauvin, D.; Woo, J.; Lovalenti, P.; Erdmann, N. B.; Goepfert, P. A.; Truong, V. L.; Bowen, R. A.; Walter, M. R.; Martinez-Sobrido, L.; Kobie, J. J.
10.1101/2022.03.05.483133 — immunology — Posted on 2022-03-07
3332 Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors
Moon, P.; Boike, L.; Dovala, D.; Henning, N. J.; Knapp, M.; Spradlin, J. N.; Ward, C. C.; Wolleb, H.; Zammit, C. M.; Fuller, D.; Blake, G.; Murphy, J. P.; Wang, F.; Lu, Y.; Moquin, S. A.; Tandeske, L.; Hesse, M. J.; McKenna, J. M.; Tallarico, J.; Schirle, M.; Toste, F. D.; Nomura, D. K.
10.1101/2022.03.05.483025 — biochemistry — Posted on 2022-03-07
3333 Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication
Moll, T.; Odon, V.; Harvey, C.; Collins, M.; Peden, A.; Franklin, J.; Graves, E.; Marshall, J.; dos Santos Souza, C.; Zhang, S.; Azzouz, M.; Gordon, D.; Krogan, N.; Ferraiuolo, L.; Snyder, M.; Shaw, P.; Rehwinkel, J.; Cooper-Knock, J.
10.1101/2022.03.06.483172 — genetics — Posted on 2022-03-07
3334 Mycobacterial virulence regulator integrates cAMP homeostasis with stress response and virulence
Khan, H.; Paul, P.; Goar, H.; Sevalkar, R. R.; Bamniya, B.; Kachhap, S.; Singh, B.; Sarkar, D.
10.1101/2022.03.07.483216 — microbiology — Posted on 2022-03-07
3336 Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer
Ranti, D.; Wang, Y.-S.; Daza, J.; Beiber, C.; Salome, B.; Merritt, E.; Cavallo, J.-A.; Hegewisch-Solloa, E.; Mace, E. M.; Farkas, A. M.; Schroff, S.; Tran, M.; Qi, J.; Patel, M.; Geanon, D.; Kelly, G.; Dereal, R.; Lee, B.; Kim-Schulze, S.; Thin, T. H.; Garcia-Barros, M.; Beaumont, K. G.; Lee, Y.; LaRoche, D.; Sebra, R.; Brody, R.; Tocheva, A.; Hopkins, B.; Wiklund, P.; Galsky, M. D.; Bhardwaj, N.; Sfakianos, J. P.; Horowitz, A.
10.1101/2022.03.06.483198 — immunology — Posted on 2022-03-07
3337 Chimeric mRNA based COVID-19 vaccine elicits potent neutralizing antibodies and protection against Omicron and Delta
Hu, Q.; Zhao, Y.; Shaabani, N.; Lyu, X.; Sun, H.; Cruz, V.; Kao, Y.; Xu, J.; Fossier, A.; Stegman, K.; Wang, Z.; Wang, Z.; Hu, Y.; Zheng, Y.; Kyaw, L.; Zuluaga, C.; Wang, H.; Pei, H.; Powers, C.; Allen, R.; Xie, H.; Ji, H.; Chen, R.
10.1101/2022.03.04.483032 — immunology — Posted on 2022-03-07
3338 Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity
Garcia-Villalba, J.; Hurtado-Navarro, L.; Penin-Franch, A.; Molina-Lopez, C.; Martinez-Alarcon, L.; Angosto-Bazarra, D.; Baroja-Mazo, A.; Pelegrin, P.
10.1101/2022.03.04.483019 — immunology — Posted on 2022-03-07
3339 Blinding efficacy and adverse events following repeated transcranial alternating current, direct current, and random noise stimulation.
Sheffield, J. G.; Rampersad, S.; Brem, A.-K.; Mansfield, K.; Orhan, U.; Dillard, M.; McKanna, J.; Plessow, F.; Thompson, T.; Santarnecchi, E.; Pascual-Leone, A.; Pavel, M.; Mathan, S.; Cohen Kadosh, R.
10.1101/2022.03.04.482999 — neuroscience — Posted on 2022-03-07
3341 Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer
Kayhanian, H.; Barmpoutis, P.; Lakatos, E.; Cross, W. C. H.; Caravagna, G.; Zapata, L.; Litchfield, K.; Steele, C. D.; Waddingham, W.; Patel, D.; Milite, S.; Jin, C.; Baker, A.-M.; Ross, C.; Alexander, D.; Khan, K.; Hochhauser, D.; Novelli, M.; Werner, B.; Guppy, N.; Linares, J.; Genomics England Research Consortium, ; Ligtenberg, M.; Nagtegaal, I.; Sottoriva, A.; Graham, T. A.; Pillay, N.; Rodriguez-Justo, M.; Shiu, K.-K.; Jansen, M.
10.1101/2022.03.06.482973 — cancer biology — Posted on 2022-03-07
3344 Mycorrhizal fungi stabilize bacterial growth and diversity in water-limited soils
Hestrin, R.; Kan, M.; Lafler, M.; Wollard, J.; Kimbrel, J.; Ray, P.; Blazewicz, S. J.; Stuart, R.; Craven, K. D.; Firestone, M. K.; Nuccio, E. E.; Pett-Ridge, J.
10.1101/2022.03.05.483112 — ecology — Posted on 2022-03-07
3345 Global analysis of human-to-mouse contact-dependent intercellular mRNA and lncRNA transfer in cell culture
Dasgupta, S.; Dyagi, D. Y.; Haimovich, G.; Wyler, E.; Olender, T.; Singer, R. H.; Landthaler, M.; Gerst, J. E.
10.1101/2021.11.28.470233 — cell biology — Posted on 2022-03-07
3346 Goal-specific brain MRI harmonization
An, L.; Chen, J.; Chen, P.; He, T.; Chen, C.; Zhou, J. H.; Yeo, B. T. T.
10.1101/2022.03.05.483077 — neuroscience — Posted on 2022-03-07
3349 ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain of function
Pant, D.; Parameswaran, J.; Rao, L.; Shi, L.; Chilukuri, G.; McEachin, Z.; Glass, J.; Bassell, G. J.; Gennerich, A.; Jiang, J.
10.1101/2022.03.05.483071 — neuroscience — Posted on 2022-03-07
3352 Comparative analysis of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
Liu, J.; Tran, V.; Vemuri, V. N. P.; Byrne, A.; Borja, M.; Agarwal, S.; Wang, R.; Awayan, K.; Murti, A.; Taychameekiatchai, A.; Wang, B.; Emanuel, G.; He, J.; Haliburton, J.; Pisco, A. O.; Neff, N.
10.1101/2022.03.04.483068 — bioinformatics — Posted on 2022-03-07
3354 GenErode: a bioinformatics pipeline to investigate genome erosion in endangered and extinct species
Kutschera, V. E.; Kierczak, M.; van der Valk, T.; von Seth, J.; Dussex, N.; Lord, E.; Dehasque, M.; Stanton, D. W. G.; Khoonsari, P. E.; Nystedt, B.; Dalen, L.; Diez-del-Molino, D.
10.1101/2022.03.04.482637 — bioinformatics — Posted on 2022-03-07
3357 Neuromuscular embodiment of feedback control elements in Drosophila flight
Whitehead, S. C.; Leone, S.; Lindsay, T.; Meiselman, M. R.; Cowan, N.; Dickinson, M. H.; Yapici, N.; Stern, D.; Shirangi, T.; Cohen, I.
10.1101/2022.02.22.481344 — animal behavior and cognition — Posted on 2022-03-07
3360 Identifying the C. elegans vulval transcriptome
Zhang, Q.; Hrach, H.; Mangone, M.; Reiner, D. J.
10.1101/2022.03.06.483199 — genetics — Posted on 2022-03-07
3361 Distal-less and spalt are distal organisers of pierid wing patterns
Wee, J. L. Q.; Banerjee, T. D.; Prakash, A.; Seah, K. S.; Monteiro, A.
10.1101/2021.09.02.458688 — evolutionary biology — Posted on 2022-03-07
3364 Hippo Signaling Cofactor, WWTR1, at the Crossroads of Human Trophoblast Progenitor Self-Renewal and Differentiation.
Ray, S.; Saha, A.; Ghosh, A.; Roy, N.; Kumar, R. P.; Meinhardt, G.; Mukerjee, A.; Gunewardena, S.; Kumar, R.; Knofler, M.; Paul, S.
10.1101/2022.03.06.483207 — developmental biology — Posted on 2022-03-07
3366 Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium
Viacava, K.; Qiao, J.; Janowczyk, A.; Poudel, S.; Jacquemin, N.; Meibom, K. L.; Shrestha, H. K.; Reid, M. C.; Hettich, R. L.; Bernier-Latmani, R.
10.1101/2022.01.25.477449 — microbiology — Posted on 2022-03-07
3368 PTEN is required for human Treg suppression of costimulation
Lam, A. J.; Haque, M.; Ward-Hartstonge, K. A.; Uday, P.; Wardell, C. M.; Gillies, J. K.; Speck, M.; Mojibian, M.; Geltink, R. I. K.; Levings, M. K.
10.1101/2022.03.06.483188 — immunology — Posted on 2022-03-07
3369 Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defineshyperactivated Tregs as a potential therapeutic target
Alvisi, G.; Termanini, A.; Soldani, C.; Portale, F.; Carriero, R.; Pilipow, K.; Polidoro, M.; Franceschini, B.; Malenica, I.; Puccio, S.; Lise, V.; Zanon, V.; Colombo, F. S.; Tufano, M.; Peano, C.; Aghemo, A.; Di Tommaso, L.; Cibella, J.; Iannacone, M.; Roychoudhuri, R.; Donadon, M.; Torzilli, G.; Kunderfranco, P.; Dimitri, D.; Lugli, E.; Lleo, A.
10.1101/2022.03.06.483155 — immunology — Posted on 2022-03-07
3370 Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies
Cao, Y.; Yisimayi, A.; Jian, F.; Xiao, T.; Song, W.; Wang, J.; Du, S.; Zhang, Z.; Liu, P.; Hao, X.; Li, Q.; Chen, X.; Wang, L.; Wang, P.; An, R.; Wang, Y.; Wang, J.; Yang, P.; Sun, H.; Zhao, L.; Zhang, W.; Zhao, D.; Zheng, J.; Yu, L.; Li, C.; Zhang, N.; Wang, R.; Niu, X.; Yang, S.; Song, X.; Zheng, L.; Li, Z.; Gu, Q.; Shao, F.; Huang, W.; Wang, Y.; Shen, Z.; Wang, X.; Jin, R.; Xiao, J.; Xie, X. S.
10.1101/2022.02.07.479349 — immunology — Posted on 2022-03-07
3374 Emergence of hyper insecticide-resistant dengue vectors in Indochina Peninsula: threats of concomitant knockdown resistance mutations
Kasai, S.; Itokawa, K.; Uemura, N.; Takaoka, A.; Furutani, S.; Maekawa, Y.; Kobayashi, D.; Imanishi-Koayashi, N.; Amoa-Bosompem, M.; Murota, K.; Higa, Y.; Kawada, H.; Minakawa, N.; Cuong, T. C.; Yen, N. T.; Phong, T. V.; Keo, S.; Kang, K.; Miura, K.; Ng, L. C.; Teng, H.-J.; Dadzie, S.; Subekti, S.; Mulyatno, K. C.; Sawabe, K.; Tomita, T.; Komagata, O.
10.1101/2022.03.05.483084 — neuroscience — Posted on 2022-03-07
3378 A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies.
Wasielewska, J. M.; Chaves, J. C. S.; Johnston, R. L.; Milton, L. A.; Hernández, D.; Chen, L.; Song, J.; Lee, W.; Leinenga, G.; Nisbet, R. M.; Pébay, A.; Götz, J.; White, A. R.; Oikari, L. E.
10.1101/2022.03.06.483200 — neuroscience — Posted on 2022-03-07
3379 Widespread hybridization between invasive bleak (Alburnus alburnus) and native Iberian chubs (Squalius spp.): a neglected threat
Morgado-Santos, M.; Curto, M.; Alexandre, C. M.; Alves, M. J.; Gante, H. F.; Gkenas, C.; Medeiros, J. P.; Pinheiro, P. J.; Almeida, P. R.; Magalhaes, M. F.; Ribeiro, F.
10.1101/2022.03.04.483063 — zoology — Posted on 2022-03-07
3381 Dietary Lipid Oxidization Products Alter Growth, Adiposity and Gut Microbial Ecology in Prepubertal Porcine Model
Arowolo, F. K.; Willis, K. A.; Karabayir, I.; Akbiligic, O.; Blaser, M.; Booth, J.; Pierre, J. F.; Shanmuganayagam, D.
10.1101/2022.03.06.483183 — physiology — Posted on 2022-03-07
3382 A photoswitchable ligand targeting β1-adrenoceptor enables light-control of the cardiac rhythm
Duran-Corbera, A.; Faria, M.; Ma, Y.; Prats, E.; Dias, A.; Catena, J.; Martinez, K. L.; Raldua, D.; Llebaria, A.; Rovira, X.
10.1101/2022.03.06.483174 — pharmacology and toxicology — Posted on 2022-03-07
3383 Systematic analysis uncovers SYK dependency in NF1LoF melanoma cells
Abecunas, C.; Whitehead, C.; Ziemke, E.; Baumann, D. G.; Frankowski-McGregor, C.; Sebolt-Leopold, J.; Fallahi-Sichani, M.
10.1101/2022.03.06.483170 — cancer biology — Posted on 2022-03-07
3384 Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer
Zhang, H.; Karnoub, E.-R.; Umeda, S.; Chaligne, R.; Masilionis, I.; McIntyre, C. A.; Hayashi, A.; Sashittal, P.; Zucker, A.; Mullen, K.; Makohon-Moore, A.; Iacobuzio-Donahue, C. A.
10.1101/2022.03.06.483206 — cancer biology — Posted on 2022-03-07
3385 A comprehensive analysis of immune landscape of Indian triple negative breast cancer
Korlimarla, A.; PS, H.; Prabhu, J.; Ragulan, C.; Patil, Y.; VP, S.; Desai, K.; Mathew, A.; Cheang, M.; Sadanandam, A.
10.1101/2022.03.06.483159 — cancer biology — Posted on 2022-03-07
3387 An actin-like filament from Clostridium botulinum exhibits a novel mechanism of filament dynamics
Koh, A.; Ali, S.; Popp, D.; Tanaka, K.; Kitaoku, Y.; Miyazaki, N.; Kenji, I.; Mitsuoka, K.; Robinson, R. C.; Narita, A.
10.1101/2022.03.07.483215 — biophysics — Posted on 2022-03-07
3391 vissE: A versatile tool to identify and visualise higher-order molecular phenotypes from functional enrichment analysis
Bhuva, D. D.; Tan, C. W.; Liu, N.; Whitfield, H. J.; Papachristos, N.; Lee, S.; Kharbanda, M.; Mohamed, A.; Davis, M. J.
10.1101/2022.03.06.483195 — bioinformatics — Posted on 2022-03-07
3392 iPheGWAS : an intelligent computational framework to integrate and visualise genome-phenome wide association studies
George, G.; Huang, Y.; Gan, S.; Nar, A. S.; Ha, J.; Venkatesan, R.; Mohan, V.; Wang, H.; Brown, A.; Palmer, C. N. A.; Doney, A.
10.1101/2022.03.05.483121 — bioinformatics — Posted on 2022-03-07
3394 Structural maturation of SYCP1-mediated meiotic chromosome synapsis through conformational remodelling by molecular adapter SYCE3
Crichton, J. H.; Dunce, J. M.; Dunne, O. M.; Salmon, L. J.; Devenney, P. S.; Lawson, J.; Adams, I. R.; Davies, O. R.
10.1101/2022.03.06.483192 — biochemistry — Posted on 2022-03-07
3395 Cell type-specific prediction of 3D chromatin architecture
Tan, J.; Rodriguez-Hernaez, J.; Sakellaropoulos, T.; Boccalatte, F.; Aifantis, I.; Skok, J.; Fenyo, D.; Xia, B.; Tsirigos, A.
10.1101/2022.03.05.483136 — genomics — Posted on 2022-03-07
3398 Timing of neurogenesis through sequential accumulation of miR-9 due to additive expression of multiple alleles
Soto, X.; Burton, J.; Manning, C. S.; Minchington, T.; Lea, R.; Lee, J.; Kursawe, J.; Rattray, M.; Papalopulu, N.
10.1101/2020.08.03.233890 — developmental biology — Posted on 2022-03-07
3399 Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease.
Salvadores, N.; Moreno, I.; Gamez, N.; Quiroz, G.; Vegas, L.; Escandon, M.; Jimenez, S.; Vitorica, J.; Gutierrez, A.; Soto, C.; Court, F.
10.1101/2021.08.27.457960 — cell biology — Posted on 2022-03-07
3401 Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies Against Delta and Omicron in Mice
Jansen van Vuren, P.; McAuley, A. J.; Kuiper, M. J.; Singanallur, N. B.; Bruce, M. P.; Riddell, S.; Goldie, S.; Mangalaganesh, S.; Chahal, S.; Drew, T. W.; Blasdell, K. R.; Tachedjian, M.; Caly, L.; Druce, J. D.; Ahmed, S.; Khan, M. S.; Malladi, S. K.; Singh, R.; Pandey, S.; Varadarajan, R.; Vasan, S. S.
10.1101/2022.03.03.481940 — immunology — Posted on 2022-03-07
3402 Drawing the experience dynamics of meditation.
Jachs, B.; Garcia, M. C.; Canales-Johnson, A.; Bekinschtein, T.
10.1101/2022.03.04.482237 — neuroscience — Posted on 2022-03-07
3403 Cholinergic forebrain activation improves cognition, boosts neurotrophin receptors, and lowers Aβ42 levels in the cerebral cortex of 5xFAD mice.
Kumro, J.; Tripathi, A.; Lei, Y.; Sword, J. J.; Callahan, P.; Terry, A. V.; Lu, X.-Y.; Kirov, S.; Pillai, A. R.; Blake, D. T.
10.1101/2022.03.04.482983 — neuroscience — Posted on 2022-03-07
3406 Seasonal changes in membrane structure and excitability in central neurons of goldfish (Carassius auratus) under constant environmental conditions
Country, M. W.; Haase, K.; Blank, K.; Canez, C. R.; Roberts, J. A.; Campbell, B. F. N.; Smith, J. C.; Pelling, A. E.; Jonz, M. G.
10.1101/2022.03.04.483033 — neuroscience — Posted on 2022-03-07
3408 Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony
Ceanga, M.; Rahmati, V.; Haselmann, H.; Schmidl, L.; Hunter, D.; Kreye, J.; Pruess, H.; Groc, L.; Hallermann, S.; Dalmau, J.; Ori, A.; Heckmann, M.; Geis, C.
10.1101/2022.03.04.482796 — neuroscience — Posted on 2022-03-07
3411 Hierarchical organization of spontaneous co-fluctuations in densely-sampled individuals using fMRI
Betzel, R.; Cutts, S.; Tanner, J.; Greenwell, S.; Varley, T.; Faskowitz, J.; Sporns, O.
10.1101/2022.03.06.483045 — neuroscience — Posted on 2022-03-07
3412 A cadherin mutation in Celsr3 linked to Tourette Disorder affects dendritic patterning and excitability of cholinergic interneurons
Poppi, L. A.; Ho-Nguyen, K.; Wu, J.; Matrongolo, M.; Thackray, J. K.; Nasello, C.; Shi, A.; Ricci, M.; McGinnis, J.; Carayannopoulos, N. L.; Cheedalla, N.; Schaper, S.; Daut, C.; Hernandez, J.; Heiman, G. A.; Tischfield, J. A.; Tischfield, M. A.
10.1101/2022.03.06.483205 — neuroscience — Posted on 2022-03-07
3414 Pliable synaptic fidelity and excitatory inter-synaptic crosstalk in the intact brain
Reynolds, J. P.; Jensen, T. P.; Rama, S.; Zheng, K.; Savtchenko, L.; Rusakov, D. A.
10.1101/2022.03.04.483016 — neuroscience — Posted on 2022-03-07
3417 AI-powered pan-species computational pathology: bridging clinic and wildlife care
AbdulJabbar, K.; Castillo, S. P.; Hughes, K.; Davidson, H.; Boddy, A. M.; Abegglen, L. M.; Murchinson, E. P.; Graham, T. A.; Spiro, S.; Palmieri, C.; Yuan, Y.
10.1101/2022.03.05.482261 — cancer biology — Posted on 2022-03-07
3419 Information-theoretic clustering for single-cell transcriptomics
Casey, M. J.; Fliege, J.; Sanchez-Garcia, R. J.; MacArthur, B. D.
10.1101/2020.10.01.322255 — bioinformatics — Posted on 2022-03-07
3420 Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal
Roushar, F. J.; McKee, A. G.; Kuntz, C. P.; Ortega, J. T.; Penn, W. D.; Woods, H.; Chamness, L. M.; Most, V.; Meiler, J.; Jastrzebska, B.; Schlebach, J. P.
10.1101/2022.03.01.482516 — biochemistry — Posted on 2022-03-07
3422 The 3D structure of lipidic fibrils of α-synuclein
Frieg, B.; Antonschmidt, L.; Dienemann, C.; Geraets, J. A.; Najbauer, E. E.; Matthes, D.; de Groot, B. L.; Andreas, L. B.; Becker, S.; Griesinger, C.; Schroder, G. F.
10.1101/2022.03.02.481946 — molecular biology — Posted on 2022-03-07
3423 Inferring causal connectivity from pairwise recordings and optogenetics
Lepperod, M. E.; Stöber, T. M.; Hafting, T.; Fyhn, M.; Kording, K. P.
10.1101/463760 — neuroscience — Posted on 2022-03-07
3425 Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum
Wang, Y.; Chai, L.; Chu, C.; Li, D.; Gao, C.; Wu, X.; Yang, Z.; Zhang, Y.; Xu, J.; Nyengaard, J. R.; Eickhoff, S. B.; Liu, B.; Madsen, K. H.; Jiang, T.; Fan, L.
10.1101/2021.06.23.448673 — neuroscience — Posted on 2022-03-07
3428 S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signalling.
Hurst, C. H.; Turnbull, D.; Gronnier, J.; Myles, S.; Pflughaupt, R. L.; Kopischke, M.; Davies, P.; Jones, S.; Robatzek, S.; Zipfel, C.; Hemsley, P.
10.1101/2021.08.30.457756 — plant biology — Posted on 2022-03-07
3430 Massively parallel, computationally-guided design of a pro-enzyme
Yachnin, B. J.; Azouz, L. R.; White, R. E.; Minetti, C. A. S. A.; Remeta, D. P.; Tan, V. M.; Drake, J. M.; Khare, S. D.
10.1101/2021.03.25.437042 — biophysics — Posted on 2022-03-07
3431 Automated 3D reconstruction of the fetal thorax in the standard atlas space from motion-corrupted MRI stacks for 21-36 weeks GA range
Uus, A.; Grigorescu, I.; van Poppel, M. P. M.; Steinweg, J. K.; Roberts, T. A.; Rutherford, M. A.; Hajnal, J. V.; Lloyd, D. F. A.; Pushparajah, K.; Deprez, M.
10.1101/2021.09.22.461335 — bioinformatics — Posted on 2022-03-07
3432 Higher phage virulence accelerates the evolution of host resistance
Wendling, C. C.; Lange, J.; Liesegang, H.; Sieber, M.; Poehlein, A.; Bunk, B.; Reikov, J.; Goehlich, H.; Roth, O.; Brockhurst, M.
10.1101/2021.03.26.437141 — evolutionary biology — Posted on 2022-03-07
3434 LanA (Language Atlas): A probabilistic atlas for the language network based on fMRI data from >800 individuals
Lipkin, B.; Tuckute, G.; Affourtit, J.; Small, H.; Mineroff, Z.; Kean, H.; Jouravlev, O.; Rakocevic, L.; Pritchett, B.; Siegelman, M.; Hoeflin, C.; Pongos, A.; Blank, I.; Shruhl, M. K.; Ivanova, A.; Shannon, S.; Sathe, A.; Hoffmann, M.; Nieto-Castanon, A.; Fedorenko, E.
10.1101/2022.03.06.483177 — neuroscience — Posted on 2022-03-07
3435 Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects
Solman, M.; Blokzijl-Franke, S.; Piques, F.; Yan, C.; Yang, Q.; Strullu, M.; Kamel, S. M.; Ak, P.; Bakkers, J.; Langenau, D. M.; Cave, H.; den Hertog, J.
10.1101/2020.09.10.289090 — developmental biology — Posted on 2022-03-07
3438 Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody
Xie, B.; Maker, A.; Priest, A. V.; Dranow, D. M.; Phan, J. N.; Edwards, T. E.; Staker, B.; Myler, P. J.; Gumbiner, B. M.; Sivasankar, S.
10.1101/2022.03.06.483190 — biophysics — Posted on 2022-03-06
3443 SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
Liu, W.; Lu, X.; Zhao, Z.; Li, Q.; Xue, Y.; Gao, Z.; Sun, S.; Lei, W.; Li, L.; An, G.; Liu, H.; Han, Z.; Ouyang, Y.-C.; Hou, Y.; Wang, Z.-B.; Sun, Q.; Liu, J.
10.1101/2022.03.06.483179 — developmental biology — Posted on 2022-03-06
3444 Cilia regulate meiotic recombination in zebrafish
Xie, H.; Wang, X.; Jin, M.; Li, L.; Zhu, J.; Kang, Y.; Chen, Z.; Sun, Y.; Zhao, C.
10.1101/2022.03.05.482955 — developmental biology — Posted on 2022-03-06
3445 ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum
McCoy, C.; Paupelin-Vaucelle, H.; Gorilak, P.; Beneke, T.; Varga, V.; Gluenz, E.
10.1101/2022.03.06.483169 — cell biology — Posted on 2022-03-06
3446 Predicting butyrate- and propionate-forming bacteria of gut microbiota from sequencing data
Kircher, B.; Woltemate, S.; Gutzki, F.; Schlueter, D.; Geffers, R.; Baehre, H.; Vital, M.
10.1101/2022.03.06.483156 — microbiology — Posted on 2022-03-06
3447 Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks
Heyman, O.; Yehezkel, D.; Blumberger, N.; Rosenberg, G.; Ciolli Mattioli, C.; Solomon, A.; Hoffman, D.; Bossel Ben-Moshe, N.; Avraham, R.
10.1101/2022.03.06.483158 — microbiology — Posted on 2022-03-06
3449 A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer
Woo, X. Y.; Srivastava, A.; Mack, P. C.; Graber, J. H.; Sanderson, B. J.; Lloyd, M. W.; Chen, M.; Domanskyi, S.; Gandour-Edwards, R.; Tsai, R. A.; Keck, J.; Cheng, M.; Bundy, M.; Jocoy, E. L.; Riess, J. W.; Holland, W.; Grubb, S. C.; Peterson, J. G.; Stafford, G. A.; Paisie, C.; Neuhauser, S. B.; Karuturi, R. K. M.; George, J.; Simons, A. K.; Chavaree, M.; Tepper, C. G.; Goodwin, N.; Airhart, S. D.; Lara, P. N.; Openshaw, T. H.; Liu, E. T.; Gandara, D. R.; Bult, C. J.
10.1101/2022.03.06.483171 — cancer biology — Posted on 2022-03-06
3450 Increased frequencies of IgH locus suicide recombination points on Chronic Lymphocytic Leukemia with low rate of AID related somatic mutations, cMYC overexpression and short telomeres
Al Jamal, I.; Parquet, M.; Boutouil, H.; Guiyedi, K.; Rizzo, D.; Dupont, M.; Boulin, M.; El Hamel, C.; Lerat, J.; Aoufouchi, S.; Al Hamaoui, S.; Makdissy, N.; Feuillard, J.; Gachard, N.; Peron, S.
10.1101/2022.03.06.482661 — cancer biology — Posted on 2022-03-06
3451 Incorporating the image formation process into deep learning improves network performance in deconvolution applications
Li, Y.; Su, Y.; Guo, M.; Han, X.; Liu, J.; Vishwasrao, H.; Li, X.; Christensen, R.; Sengupta, T.; Moyle, M.; Chen, J.; Usdin, T. B.; Colon-Ramos, D.; Liu, H.; Wu, Y.; Shroff, H.
10.1101/2022.03.05.483139 — biophysics — Posted on 2022-03-06
3454 Ultrasensitive Dopamine Detection with Graphene Aptasensor Multitransistor Arrays
Abrantes, M.; Rodrigues, D.; Domingues, T.; Nemala, S. S.; Monteiro, P.; Borme, J.; Alpuim, P.; Jacinto, L.
10.1101/2022.03.04.483061 — bioengineering — Posted on 2022-03-06
3455 Systematic Characterization of Double Emulsion Droplets for Biological Applications
Calhoun, S. G. K.; Brower, K. K.; Chandran Suja, V.; Kim, G.; Wang, N.; McCully, A. L.; Kusumaatmaja, H.; Fuller, G. G.; Fordyce, P. M.
10.1101/2022.03.04.483054 — bioengineering — Posted on 2022-03-06
3457 Automated assembly of high-quality diploid human reference genomes
Jarvis, E. D.; Formenti, G.; Rhie, A.; Guarracino, A.; Yang, C.; Wood, J.; Tracey, A.; Thibaud-Nissen, F.; Vollger, M. R.; Porubsky, D.; Cheng, H.; Asri, M.; Logsdon, G. A.; Carnevali, P.; Chaisson, M.; Chin, C.-S.; Cody, S.; Collins, J.; Ebert, P.; Escalona, M.; Fedrigo, O.; Fulton, R. S.; Fulton, L. L.; Garg, S.; Ghurye, J.; Green, E.; Hall, I. M.; Harvey, W. H.; Hasenfeld, P.; Hastie, A.; Haukness, M.; Jain, M.; Kirsche, M.; Kolmogorov, M.; Korbel, J. O.; Koren, S.; Korlach, J.; Lee, J.; Li, D.; Lindsay, T.; Lucas, J.; Luo, F.; Marschall, T.; McDaniel, J.; Nie, F.; Olsen, H. E.; Olson, N.;
10.1101/2022.03.06.483034 — genomics — Posted on 2022-03-06
3459 Evidence for adaptive morphological plasticity in the Caribbean coral, Acropora cervicornis.
Million, W. C.; Ruggeri, M.; O'Donnell, S.; Bartels, E.; Krediet, C. J.; Kenkel, C. D.
10.1101/2022.03.04.483038 — ecology — Posted on 2022-03-06
3460 Lack of robust evidence for a Wolbachia infection in Anopheles gambiae from Burkina Faso
Sawadogo, S. P.; Kabore, D. A.; Tibiri, E. B.; Hughes, A.; Gnankine, O.; Quek, S.; Diabate, A.; Ranson, H.; Hughes, G. L.; Dabire, R. K.
10.1101/2022.03.05.483130 — ecology — Posted on 2022-03-06
3463 Revealing cell populations catching the early stages of the human embryo development in naive pluripotent stem cells
Moya-Jodar, M.; Ullate-Agote, A.; Barlabe, P.; Rodriguez-Madoz, J. R.; Abizanda, G.; Barreda, C.; Carvajal-Vergara, X.; Vilas-Zornoza, A.; Romero, J. P.; Garate, L.; Agirre, X.; Coppiello, G.; Prosper, F.; Aranguren, X.
10.1101/2022.03.06.482812 — cell biology — Posted on 2022-03-06
3464 LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression
Jiao, J.-W.; Zhan, X.-H.; Wang, J.-J.; He, L.-X.; Guo, Z.-C.; Xu, X.-E.; Liao, L.-D.; Huang, X.; Wen, B.; Xu, Y.-W.; Hu, H.; Neufeld, G.; Chang, Z.-J.; Zhang, K.; Xu, L.-Y.; Li, E.-M.
10.1101/2022.03.06.483165 — cell biology — Posted on 2022-03-06
3465 Possible Mechanism of Porosome-Mediated Exosome Release
Cho, W. J.; Formosa, B.; Zhvania, M. G.; Taatjes, D. J.; Ghiran, I.; Jena, B. P.
10.1101/2022.03.06.483164 — cell biology — Posted on 2022-03-06
3466 Transcriptional circuitry of NKX2-1 and SOX1 defines an unrecognized lineage subtype of small cell lung cancer
Kong, R.; Patel, A. S.; Sato, T.; Yoo, S.; Bao, L.; Sinha, A.; Jiang, F.; tian, y.; Fridrikh, M.; Liu, S.; Feng, J.; He, X.; Jiang, J.; Ma, Y.; Grullon, K.; Yang, D.; Powell, C. A.; Beasley, M. B.; Zhu, J.; Snyder, E.; Li, S.; Watanabe, H.
10.1101/2022.03.06.483161 — molecular biology — Posted on 2022-03-06
3468 Downregulation of the secreted protein with an altered thrombospondin repeat (SPATR) impacts the infectivity of malaria sporozoites
Costa, D. M.; Sa, M.; Teixeira, A. R.; Perez-Cabezas, B.; Golba, S.; Sefiane-Djemaoune, H.; Formaglio, P.; Franke-Fayard, B.; Janse, C. J.; Amino, R.; Tavares, J.
10.1101/2022.03.06.483110 — microbiology — Posted on 2022-03-06
3469 Putative SET-domain methyltransferases in Cryptosporidium parvum and histone methylation during infection
Sawant, M.; Benamrouz-Vanneste, S.; Meloni, D.; Gantois, N.; Even, G.; Guyot, K.; Creusy, C.; Duval, E.; Wintjens, R.; Weitzman, J.; Chabe, M.; Viscogliosi, E.; Certad, G.
10.1101/2022.03.06.483160 — microbiology — Posted on 2022-03-06
3474 TrmB family transcription factor as a thiol-based regulator of oxidative stress response
Mondragon, P.; Hwang, S.; Kasirajan, L.; Oyetoro, R.; Nasthas, A.; Winters, E.; Couto-Rodriguez, R. L.; Schmid, A.; Maupin-Furlow, J. A.
10.1101/2022.03.05.483106 — microbiology — Posted on 2022-03-06
3476 Mice regulate their attentional intensity and arousal to exploit increases in task utility
de Gee, J. W.; Mridha, Z.; Hudson, M.; Shi, Y.; Ramsaywak, H.; Smith, S.; Karediya, N.; Thompson, M.; Jaspe, K.; Zhang, W.; McGinley, M. J.
10.1101/2022.03.04.482962 — neuroscience — Posted on 2022-03-06
3477 PANDORA: a fast, anchor-restrained modelling protocol for peptide:MHC complexes
Parizi, F. M.; Marzella, D. F.; Van Tilborg, D.; Renaud, N.; Sybrandi, D.; Buzatu, R.; Xue, L. C.
10.1101/2022.03.04.482467 — bioinformatics — Posted on 2022-03-06
3478 Robust differential composition and variability analysis for multisample cell omics
Mangiola, S.; Schulze, A.; Trussart, M.; Zozaya, E.; Ma, M.; Zijie, G.; Rubin, A. F.; Shim, H. S.; Speed, T. P.; Papenfuss, A. T.
10.1101/2022.03.04.482758 — bioinformatics — Posted on 2022-03-06
3479 Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications
Candarlioglu, P. L.; Jadalannagari, S.; Chaff, J.; Velez, J.; Joshipura, S. R.; Kanellias, M.; Simpson, A. P.; Kerns, S. J.; Ewart, L.; Hegde, M.; Ekert, J.
10.1101/2022.03.04.482954 — bioengineering — Posted on 2022-03-06
3480 Modeling of individual neurophysiological brain connectivity
Kulik, S. D.; Douw, L.; van Dellen, E.; Steenwijk, M. D.; Geurts, J. J.; Stam, K. J.; Hillebrand, A.; Schoonheim, M. M.; Tewarie, P.
10.1101/2022.03.02.482608 — neuroscience — Posted on 2022-03-06
3481 ISL1 is necessary for auditory neuron development and tonotopic organization
Filova, I.; Pysanenko, K.; Tavakoli, M.; Vochyanova, S.; Dvorakova, M.; Bohuslavova, R.; Smolik, O.; Fabriciova, V.; Hrabalova, P.; Benesova, S.; Valihrach, L.; Cerny, J.; Yamoah, E. N.; Syka, J.; Fritzsch, B.; Pavlinkova, G.
10.1101/2021.09.03.458707 — neuroscience — Posted on 2022-03-06
3482 Protein Optimization Evolving Tool (POET) based on Genetic Programming
Bricco, A. R.; Miralavy, I.; Bo, S.; Perlman, O.; Farrar, C. T.; McMahon,, M. T.; Banzhaf, W.; Gilad, A.
10.1101/2022.03.05.483103 — synthetic biology — Posted on 2022-03-06
3485 Stress-dependent cell stiffening by tardigrade tolerance proteins through reversible formation of cytoskeleton-like filamentous network and gel-transition
Tanaka, A.; Nakano, T.; Watanabe, K.; Masuda, K.; Honda, G.; Kamata, S.; Yasui, R.; Kozuka-Hata, H.; Watanabe, C.; Chinen, T.; Kitagawa, D.; Sawai, S.; Oyama, M.; Yanagisawa, M.; Kunieda, T.
10.1101/2021.10.02.462891 — biochemistry — Posted on 2022-03-06
3486 EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin
Ponde, N. O.; Lortal, L.; Tsavou, A.; Hepworth, O.; Ho, J.; Richardson, J.; Moyes, D. L.; Gaffen, S.; Naglik, J. R.
10.1101/2022.03.05.483111 — microbiology — Posted on 2022-03-06
3487 Extracellular Matrix Levels Modulate Outgrowths Dynamics in Ovarian Cancer.
Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.
10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-03-05
3491 Mechanistic insights into the enhancement or inhibition of phase separation by polyubiquitin chains of different lengths or linkages
Dao, T. P.; Yang, Y.; Presti, M. F.; Cosgrove, M. S.; Hopkins, J. B.; Ma, W.; Loh, S. N.; Castaneda, C. A.
10.1101/2021.11.12.467822 — biophysics — Posted on 2022-03-05
3492 FAM172A controls the nuclear import and alternative splicing function of AGO2
Sallis, S.; Berube-Simard, F.-A.; Grondin, B.; Leduc, E.; Azouz, F.; Belanger, C.; Pilon, N.
10.1101/2022.03.04.482948 — developmental biology — Posted on 2022-03-05
3494 Regional variation in cholinergic terminal activity determines the non-uniform occurrence of cortical slow-wave activity during REM sleep
Nazari, M.; Abadchi, J. K.; Naghizadeh, M.; Contreras, E. B.; Tatsuno, M.; McNaughton, B. L.; Mohajerani, M. H.
10.1101/2022.03.01.481863 — neuroscience — Posted on 2022-03-05
3495 Infant brain regional cerebral blood flow dynamics supporting emergence of vital functional networks
Yu, Q.; Ouyang, M.; Detre, J. A.; Kang, H.; Hu, D.; Hong, B.; Fang, F.; Peng, Y.; Huang, H.
10.1101/2021.02.08.430158 — neuroscience — Posted on 2022-03-05
3496 Introduction of a condensed, reverse tricarboxylic acid cycle for additional CO2 fixation in plants
Wilson, N. J.; Smith-Moore, C. M.; Xu, Y.; Edwards, B.; La Hovary, C.; Barampuram, S.; Lin, X.; Li, K.; Aslett, D.; Ji, M.; Vintila, S.; Kleiner, M.; Xie, D.; Shachar-Hill, Y.; Grunden, A.; Sederoff, H.
10.1101/2022.03.04.483018 — plant biology — Posted on 2022-03-05
3497 Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation
Granade, M. E.; Hargett, S. R.; Lemke, M. C.; Luse, M. A.; Bochkis, I.; Linden, J.; Harris, T. E.
10.1101/2022.03.04.482364 — physiology — Posted on 2022-03-05
3498 Developing High-Affinity Decoy Receptor Optimized for Multiple Myeloma and Diffuse Large B Cell Lymphoma Treatment
Miao, Y. R.; Thakkar, K.; Cenik, C.; Jiang, D.; Mizuno, K.; Jia, C.; Li, G. C.; Zhao, H.; Diep, A.; Xu, J. Y.; Zhang, X. E.; Yang, T. T. C.; Liedtke, M.; Abidi, P.; Leung, W.-s.; Koong, A. C.; Giaccia, A. J.
10.1101/2021.05.03.442500 — cancer biology — Posted on 2022-03-05
3500 Predicting the pathogenicity of missense variants using features derived from AlphaFold2
Schmidt, A.; Roener, S.; Mai, K.; Klinkhammer, H.; Kircher, M.; Ludwig, K. U.
10.1101/2022.03.05.483091 — genetics — Posted on 2022-03-05
3501 Assembly of functional diversity in an oceanic island flora
Barajas Barbosa, M. P.; Craven, D.; Weigelt, P.; Denelle, P.; Otto, R.; Diaz, S.; Price, J.; Fernandez-Palacios, J. M.; Kreft, H.
10.1101/2022.03.04.482684 — ecology — Posted on 2022-03-05
3502 Genomic and Transcriptomic Profiling of Phoenix Colonies
Sindeldecker, D.; Dunn, M. J.; Zimmer, A.; Anderson, M. Z.; Alfonzo, J.; Stoodley, P.
10.1101/2022.03.05.483082 — microbiology — Posted on 2022-03-05
3503 Circulating mast cell progenitors migrate to atopic dermatitis-like skin then adapt locally
Keith, Y. H.; Honda, T.; Ono, S.; Lee, B.; Hanakawa, S.; Ishida, Y.; Kabashima, K.
10.1101/2022.03.04.483030 — immunology — Posted on 2022-03-05
3505 Design of the mammalian cone photoreceptor to Off bipolar cell synapse
Grabner, C.; Futagi, D.; Shi, J.; Bindokas, V. P.; Kitano, K.; Schwartz, E. A.; DeVries, S. H.
10.1101/2022.03.04.483056 — neuroscience — Posted on 2022-03-05
3508 Towards resolution of the intron retention paradox in breast cancer
Shah, J. S.; Milevskiy, M.; Petrova, V.; Au, A. Y.; Wong, J. J. L.; Visvader, J. E.; Schmitz, U.; Rasko, J. E. J.
10.1101/2022.03.04.482791 — cancer biology — Posted on 2022-03-05
3512 Moving Yeasts: Resolving the Mystery
Puri, G. M.; Chaudhari, S. K.; Inamdar, A.; Kohli, M. B.; Sangawe, V. V.; Jadhav, C. S.; Teja, L.; Adhapure, N. N.
10.1101/2022.03.05.483086 — microbiology — Posted on 2022-03-05
3513 Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis
Zhai, L.; Huang, C.; Ning, Z.; Zhang, Y.; Zhuang, M.; Yang, W.; Wang, X.; Wang, J.; Zhang, E. L.; Xiao, H.; Zhao, L.; Lam, Y. Y.; Chow, C. F. W.; Huang, J.; Yuan, S.; Chan, K. M.; Wong, H. L. X.; Bian, Z.-x.
10.1101/2022.03.05.483096 — microbiology — Posted on 2022-03-05
3514 Gut microbiota-derived tryptamine impairs insulin sensitivity
Zhai, L.; Xiao, H.; Lin, C.; Lam, Y. Y.; Wong, H. L. X.; Gong, M.; Wu, G.; Deng, Y.; Ning, Z.; Huang, C.; Zhang, Y.; Zhuang, M.; Chao, Y.; Zhang, E. L.; Zhao, L.; Zhang, C.; Fang, X.; Jia, W.; Zhao, L.; Bian, Z.-x.
10.1101/2022.03.05.483098 — microbiology — Posted on 2022-03-05
3515 NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer
Salome, B.; Sfakianos, J. P.; Daza, J.; Charap, A.; Hammer, C.; Banchereau, R.; Farkas, A. M.; Geanon, D.; Kelly, G.; de Real, R. M.; Lee, B.; Beaumont, K. G.; Shroff, S.; Wang, Y. S. A.; Wang, Y.-C.; Thin, T. H.; Garcia-Barros, M.; Hegewisch-Solloa, E.; Mace, E. M.; Wang, L.; O'Donnell, T.; Chowell, D.; Fernandez-Rodriguez, R.; Skobe, M.; Taylor, N.; Kim-Schulze, S.; Sebra, R. P.; Palmer, D.; Clancy-Thompson, E.; Hammond, S.; Kamphorst, A. O.; Malmberg, K.-J.; Marcenaro, E.; Romero, P.; Brody, R.; Viard, M.; Yuki, Y.; Martin, M.; Carrington, M.; Mehrazin, R.; Wiklund, P.; Mellman, I.; Mariath
10.1101/2022.03.04.482960 — immunology — Posted on 2022-03-05
3519 Rapid in vivo multiplexed editing (RIME) of the adult mouse liver
Katsuda, T.; Cure, H.; Simeonov, K. P.; Arany, Z.; Grompe, M.; Stanger, B.
10.1101/2022.03.04.483011 — physiology — Posted on 2022-03-05
3522 Visual Perception of 3D Space and Shape in Time - Part I: 2D Space Perception by 2D Linear Translation
Afifa, U.; Carmona, J.; Dinh, A.; Espino, D.; McCarthy, T.; Ta, B.; Wilson, P.; Asdell, B.; Baik, J.; Biju, A.; Chung, S.; Dao, C.; Diamond, M.; Doustmohammadi, S.; East, A.; Fleiszig-Evans, K.; Franco, A.; Garibay-Gutierrez, A.; Guha, A.; Gunturu, R.; Handley, L.; Honore, C.; Kannan, A.; Khoo, J.; Khosla, M.; Kittur, C.; Kwon, A.; Lee, J.; Lwe, N.; Mayer, M.; Mills, E.; Pineda, D.; Pourebrahim, P.; Rajacich, J.; Rizvi, S.; Rosales, L.; Schummer, L.; Sefkow, C.; Stangel, A.; Ta, C.; Ta, I.; Tong, N.; Tsujimoto, K.; Vu, A.; Wang, H.; Yares, A.; Yamaguchi, N.; Yoon, K. W.; Yu, S.; Blaisdell, A.
10.1101/2022.03.01.482161 — neuroscience — Posted on 2022-03-05
3524 FAM172A controls the nuclear import and alternative splicing function of AGO2
Sallis, S.; Berube-Simard, F.-A.; Grondin, B.; Leduc, E.; Azouz, F.; Belanger, C.; Pilon, N.
10.1101/2022.03.04.482948 — developmental biology — Posted on 2022-03-05
3526 Molecular mechanisms of long-term light adaptation of an extremophilic alga Cyanidioschyzon merolae
Abram, M.; Kana, R.; Olofsson, D.; Pniewski, F.; Sediva, B.; Stark, M.; Fossl, D.; Slat, V.; Neumann, A.; Rader, S.; Kargul, J. M.
10.1101/2022.03.02.482653 — plant biology — Posted on 2022-03-05
3527 Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
Mo, X.; Pang, P.; Wang, Y.; Jiang, D.; Zhang, M.; Li, Y.; Wang, P.; Geng, Q.; Xie, C.; Du, H.-N.; Zhong, B.; Li, D.; Yao, J.
10.1101/2022.03.03.482857 — physiology — Posted on 2022-03-05
3528 Nanopore quality score resolution can be reduced with little effect on downstream analysis
Rivara-Espasandin, M.; Balestrazzi, L.; Dufort y Alvarez, G.; Ochoa, I.; Seroussi, G.; Smircich, P.; Sotelo-Silveira, J.; Martin, A.
10.1101/2022.03.03.482048 — bioinformatics — Posted on 2022-03-05
3529 Mouse Genomic Associations with Ex Vivo Sensitivity to Simulated Space Radiation
Cekanaviciute, E.; Tran, D.; Nguyen, H.; Lopez Macha, A.; Pariset, E.; Langley, S.; Babbi, G.; Malkani, S.; Penninckx, S.; Schisler, J. C.; Tin, N.; Karpen, G.; Costes, S. V.
10.1101/2022.03.03.482929 — genomics — Posted on 2022-03-05
3530 Post-weaning parvalbumin expression in left orbitofrontal cortex shapes sociability in female mice
Jeon, Y.-S.; Jeong, D.; Kweon, H.; Kim, J.-H.; Kim, C. Y.; Oh, Y.; Lee, Y.-H.; Kim, C. H.; Kim, S.-G.; Jeong, J.-W.; Kim, E.; Lee, S.-H.
10.1101/2022.03.04.482801 — animal behavior and cognition — Posted on 2022-03-05
3531 Lyophilization induces alterations in cryptococcal exopolysaccharide resulting in reduced antibody binding
Wear, M. P.; Hargett, A. A.; Kelly, J. E.; McConnell, S. A.; Crawford, C.; Freedberg, D. I.; Stark, R. E. E.; Casadevall, A.
10.1101/2022.03.04.483041 — microbiology — Posted on 2022-03-05
3532 Neural representations of vicarious rewards are linked to interoception and prosocial behaviour
Contreras-Huerta, L. S.; Coll, M.-P.; Bird, G.; Yu, H.; Prosser, A.; Lockwood, P. L.; Murphy, J.; Crockett, M. J.; Apps, M. A. J.
10.1101/2022.03.04.482889 — neuroscience — Posted on 2022-03-05
3533 Pinch2 is a novel regulator of myelination in the Central Nervous System
Paes de Faria, J.; Vale-Silva, R. S.; Faessler, R.; Werner, H. B.; Relvas, J.
10.1101/2022.03.04.483000 — neuroscience — Posted on 2022-03-05
3534 High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
Costello, H. M.; Krilis, G.; Grenier, C.; Severs, D.; Ivy, J. R.; Nixon, M.; Holmes, M. C.; Livingstone, D. E. W.; Hoorn, E. J.; Dhaun, N.; Bailey, M. A.
10.1101/2022.03.04.481654 — physiology — Posted on 2022-03-05
3537 The innovation of the symbiosome has enhanced the evolutionary stability of nitrogen fixation in legumes
de Faria, S. M.; Ringelberg, J. J.; Gross, E.; Koenen, E. J.; Cardoso, D.; Ametsitsi, G. K. D.; Akomatey, J.; Maluk, M.; Tak, N.; Gehlot, H. S.; Wright, K. M.; Teaumroong, N.; Songwattana, P.; de Lima, H. C.; Prin, Y.; Zartmann, C.; Sprent, J. I.; Ardley, J.; Hughes, C. E.; James, E. K.
10.1101/2022.03.04.482842 — evolutionary biology — Posted on 2022-03-05
3538 Loss of the adhesion protein Kindlin-1 stimulates tumor clearance via modulation of Tregs
Webb, E.; Dodd, G.; Bullock, E.; Muir, M.; Frame, M. C.; Serrels, A.; Brunton, V.
10.1101/2022.03.04.483014 — cancer biology — Posted on 2022-03-05
3540 Temporal and spatial dynamics mapping reveals follicle development regulated by different stromal cell populations
Xiaoqiang, S.; Zhou, J.; Kang, N.; Liu, W.; Yu, L.; Zhang, Z.; Zhang, Y.; Yue, Q.; Yang, Q.; Zhang, X.; Li, C.; Yan, G.; Sun, H.
10.1101/2022.03.04.480328 — developmental biology — Posted on 2022-03-05
3541 Conserved Pib2 regions have distinct roles in TORC1 regulation at the vacuole
Troutman, K. K.; Varlakhanova, N. V.; Tornabene, B. A.; Ramachandran, R.; Ford, M. G. J.
10.1101/2022.03.04.483060 — cell biology — Posted on 2022-03-04
3542 Connecting the Dots: PHF13 and cohesin promote polymer-polymer phase separation of chromatin into chromosomes
Rossi, F.; Buschow, R.; Glaser, L. V.; Schubert, T.; Staege, H.; Grimme, A.; Will, H.; Mielke, T.; Vingron, M.; Chiariello, A.; Kinkley, S.
10.1101/2022.03.04.482956 — cell biology — Posted on 2022-03-04
3543 Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling
Sugiyama, M. G.; Brown, A. I.; Vega-Lugo, J.; Scott, A. M.; Jaqaman, K.; Fairn, G. D.; Antonescu, C. N.
10.1101/2022.03.04.483015 — cell biology — Posted on 2022-03-04
3545 Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury
Jones, D. L.; Caporarello, N.; Meridew, J. A.; Choi, K. M.; Haak, A. J.; Link, P. A.; Tan, Q.; Ordog, T.; Ligresti, G.; Tschumperlin, D. J.
10.1101/2022.03.04.483065 — cell biology — Posted on 2022-03-04
3546 Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission
Aggarwal, A.; Liu, R.; Chen, Y.; Ralowicz, A. J.; Bergerson, S. J.; Tomaska, F.; Hanson, T. L.; Hasseman, J. P.; Reep, D.; Tsegaye, G.; Yao, P.; Ji, X.; Kloos, M.; Walpita, D.; Patel, R.; Tilberg, P. W.; Mohar, B.; Mohr, M. A.; The GENIE Project Team, ; Looger, L.; Marvin, J.; Hoppa, M.; Konnerth, A.; Kleinfeld, D.; Schreiter, E. R.; Podgorski, K.
10.1101/2022.02.13.480251 — neuroscience — Posted on 2022-03-04
3548 Snrpb, the CCMS gene, is required in neural crest cells for proper splicing of genes essential for craniofacial morphogenesis
Alam, S. S.; Kumar, S.; Beauchamp, M.-C.; Bareke, E.; Boucher, A.; Nzirorera, N.; Padilla, R.; Zhang, S. J.; Majewski, J.; Jerome-Majewska, L. A.
10.1101/2021.08.07.455514 — developmental biology — Posted on 2022-03-04
3549 Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo
Solis, G. P.; Kazemzadeh, A.; Abrami, L.; Valnohova, J.; Alvarez, C.; van der Goot, F. G.; Katanaev, V. L.
10.1101/2020.08.25.266692 — cell biology — Posted on 2022-03-04
3550 RNA G-quadruplex structure contributes to cold adaptation in plants
Yang, X.; Yu, H.; Duncan, S.; Zhang, Y.; Cheema, J.; Miller, J. B.; Zhang, J.; Kwok, C. K.; Zhang, H.; DING, Y.
10.1101/2022.03.04.482910 — molecular biology — Posted on 2022-03-04
3552 Hepatic Deletion of X-box Binding Protein 1 in Farnesoid X Receptor Null Mice Leads to Enhanced Liver Injury
Liu, X.; Khalafalla, M.; Chung, C.; Gindin, Y.; Hubchak, S.; LeCuyer, B.; Kriegermeier, A.; Zhang, D.; Qiu, W.; Ding, X.; Fang, D.; Green, R.
10.1101/2022.03.04.482879 — molecular biology — Posted on 2022-03-04
3555 Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva
Hansen, J.; Kolbe, K.; König, I. R.; Scherliess, R.; Hellfritzsch, M.; Malm, S.; Zallet, J.; Hillemann, D.; Wiesmüller, K.-H.; Herzmann, C.; Brandenburg, J. H.; Reiling, N.
10.1101/2022.03.04.483051 — microbiology — Posted on 2022-03-04
3557 Activated I-BAR IRSp53 clustering controls the formation of VASP-actin-based membrane protrusions
Tsai, F.-C.; Henderson, J. M.; Jarin, Z.; Kremneva, E.; Senju, Y.; Pernier, J.; Mikhajlov, O.; Manzi, J.; Kogan, K.; Le Clainche, C.; Voth, G. A.; Lappalainen, P.; Bassereau, P.
10.1101/2022.03.04.483020 — biophysics — Posted on 2022-03-04
3558 A dual-target herbicidal inhibitor of lysine biosynthesis
Mackie, E. R. R.; Barrow, A. S.; Christoff, R. M.; Abbott, B. M.; Gendall, A. R.; Soares da Costa, T. P.
10.1101/2022.03.04.482975 — biochemistry — Posted on 2022-03-04
3563 Type III interferons induce pyroptosis in gut epithelial cells and delay tissue restitution upon acute intestinal injury.
Sposito, B.; Mambu, J.; Bugda Gwilt, K.; Spinelli, L.; Andreeva, N.; Galland, F.; Naquet, P.; Mitsialis, V.; Thiagarajah, J. R.; Snapper, S.; Broggi, A.; Zanoni, I.
10.1101/2022.03.04.482997 — immunology — Posted on 2022-03-04
3567 Integrative transcriptomics reveals ectopic lipid homeostasis mechanisms in non-endocrine cells of the teleost pituitary
Ager-Wick, E.; Maugars, G.; von Krogh, K.; Nourizadeh-Lillabadi, R.; Siddique, K.; Fontaine, R.; Weltzien, F.-A.; Henkel, C.
10.1101/2021.06.11.448009 — physiology — Posted on 2022-03-04
3568 Hexapeptides from mammalian inhibitory hormone hunt activate and inactivate nematode reproduction
Hart, J. E.; Mohan, S.; Davies, K. G.; Ferneyhough, B.; Clarke, I. J.; Hunt, J. A.; Shnyder, S. D.; Mundy, C. R.; Howlett, D. R.; Newton, R. P.
10.1101/2021.09.28.462091 — physiology — Posted on 2022-03-04
3570 The chromatin regulator HMGA1a undergoes phase separation in the nucleus
Zhu, H.; Narita, M.; Joseph, J. A.; Krainer, G.; Arter, W. E.; Olan, I.; Saar, K. L.; Ermann, N.; Espinosa, J. R.; Shen, Y.; Kuri, M. A.; Qi, R.; Welsh, T. J.; Xu, Y.; Collepardo-Guevara, R.; Narita, M.; Knowles, T.
10.1101/2021.10.14.464384 — biophysics — Posted on 2022-03-04
3572 Optical control of CRISPR-Cas editing with cyclically caged guide RNAs
Sun, Y.-J.; Liu, J.; Li, J.-J.; Zhang, Y.; Chen, W.-D.; Cai, W.-Q.; Tang, X.-J.; Hou, J.; Wang, M.; Cheng, L.
10.1101/2022.03.04.482981 — biochemistry — Posted on 2022-03-04
3573 Hair phenotype diversity across Indriidae lemurs
Tapanes, E.; Jacobs, R. L.; Harryman, I.; Louis, E. E.; Irwin, M. T.; Kamilar, J. M.; Bradley, B. J.
10.1101/2021.10.16.464615 — evolutionary biology — Posted on 2022-03-04
3574 The multi-level regulation of clownfish metamorphosis by thyroid hormones
Roux, N.; Miura, S.; Dussene, M.; Tara, Y.; Lee, S. h.; de Bernard, S.; Reynaud, M.; Salis, P.; Barua, A.; Boulahtouf, A.; Balaguer, P.; Gauthier, K.; Lecchini, D.; Gibert, Y.; Besseau, L.; Laudet, V. C.
10.1101/2022.03.04.482938 — developmental biology — Posted on 2022-03-04
3576 An amphipathic helix in Brl1 is required for membrane fusion during nuclear pore complex biogenesis in S. cerevisiae
Kralt, A.; Wojtynek, M.; Fischer, J. S.; Agote-Aran, A.; Mancini, R.; Dultz, E.; Noor, E.; Uliana, F.; Tatarek-Nossol, M.; Antonin, W.; Onischenko, E.; Medalia, O.; Weis, K.
10.1101/2022.03.04.483005 — cell biology — Posted on 2022-03-04
3577 A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Jatzlau, J.; Burdzinski, W.; Trumpp, M.; Obendorf, L.; Rossmann, K.; Ravn, K.; Hyvoenen, M.; Bottanelli, F.; Broichhagen, J.; Knaus, P.
10.1101/2022.03.04.482944 — cell biology — Posted on 2022-03-04
3579 RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma
Lambing, S.; Holdenrieder, S.; Müller, P.; Tan, Y. P.; Hagen, C.; Garbe, S.; Schlee, M.; van den Boorn, J. G.; Bartok, E.; Hartmann, G.; Renn, M.
10.1101/2021.10.16.464638 — immunology — Posted on 2022-03-04
3581 Information Decay and Enzymatic Information Recovery for DNA Data Storage
Meiser, L. C.; Gimpel, A. L.; Deshpande, T.; Libort, G.; Chen, W. D.; Heckel, R.; Nguyen, B. H.; Strauss, K.; Stark, W. J.; Grass, R. N.
10.1101/2022.03.04.482785 — synthetic biology — Posted on 2022-03-04
3583 Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
Zhang, M. J.; Hou, K.; Dey, K. K.; Sakaue, S.; Jagadeesh, K. A.; Weinand, K.; Taychameekiatchai, A.; Rao, P.; Pisco, A. O.; Zou, J.; Wang, B.; Gandal, M.; Raychaudhuri, S.; Pasaniuc, B.; Price, A. L.
10.1101/2021.09.24.461597 — bioinformatics — Posted on 2022-03-04
3585 Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase
Kaur, S.; Nieto, N.; McDonald, P.; Beck, J. R.; Honzatko, R. B.; Roy, A.; Nelson, S. W.
10.1101/2022.03.04.482688 — biochemistry — Posted on 2022-03-04
3586 Biologically-derived neoproteoglycans for profiling protein-glycosaminoglycan interactions
Porell, R. N.; Follmar, J. L.; Purcell, S. C.; Timm, B.; Laubach, L. K.; Kozirovskiy, D.; Thacker, B. E.; Glass, C. A.; Gordts, P. L. S. M.; Godula, K.
10.1101/2022.03.04.482917 — biochemistry — Posted on 2022-03-04
3589 Elaboration of a MALDI-TOF Mass Spectrometry-based Assay of Parkin Activity and High-Throughput screening platform for Parkin Activators
Traynor, R.; Moran, J.; Stevens, M. U.; Knebel, A.; Behrouz, B.; Merchant, K.; Hastie, C. J.; Davies, P.; Muqit, M.; De Cesare, V.
10.1101/2022.03.04.482851 — biochemistry — Posted on 2022-03-04
3590 Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
Kladnik, J.; Dolinar, A.; Kljun, J.; Perea, D.; Grau-Exposito, J.; Genesca, M.; Novinec, M.; Buzon, M. J.; Turel, I.
10.1101/2022.03.03.482819 — biochemistry — Posted on 2022-03-04
3591 The Hydractinia Allorecognition Complex encodes a novel family of immunoglobulin superfamily proteins
Huene, A. L.; Sanders, S. M.; Ma, Z.; Nguyen, A.-D.; Koren, S.; Michaca, M. H.; Mullikin, J. C.; Phillippy, A. M.; Schnitzler, C.; Baxevanis, A. D.; Nicotra, M. L.
10.1101/2022.03.04.482883 — genomics — Posted on 2022-03-04
3592 Notch signaling in germ line stem cells controls reproductive aging in C. elegans
Kocsisova, Z.; Bagatelas, E. D.; Santiago-Borges, J.; Lei, H. C.; Egan, B. M.; Mosley, M. C.; Schneider, D. L.; Schedl, T.; Kornfeld, K.
10.1101/2022.03.04.482923 — genetics — Posted on 2022-03-04
3595 The interaction of calcium ions with specific residues in the SARS-CoV fusion peptide and the regulation of viral infectivity
Bidon, M. K.; Khelashvili, G.; Straus, M.; Tang, T.; Carten, J.; Weinstein, H.; Whittaker, G.; Daniel, S.
10.1101/2022.03.03.482731 — microbiology — Posted on 2022-03-04
3596 Gut microbe Lactiplantiballus plantarum undergoes different evolutionary trajectories between insects and mammals
Maritan, E.; Gallo, M.; Srutkova, D.; Jelinkova, A.; Benada, O.; Kofronova, O.; da Silva Soares, N. F.; Hudcovic, T.; Gifford, I.; Barrick, J. E.; Schwarzer, M.; Martino, M. E.
10.1101/2022.03.04.482961 — microbiology — Posted on 2022-03-04
3597 Campylobacter jejuni modulates reactive oxygen species production and NADPH oxidase 1 expression in human intestinal epithelial cells
Hong, G.; Davies, C.; Omole, Z.; Liaw, J.; Grabowska, A. D.; Canonico, B.; Corcionivoshi, N.; Wren, B. W.; Dorrell, N.; Elmi, A.; Gundogdu, O.
10.1101/2022.03.04.482506 — microbiology — Posted on 2022-03-04
3598 Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies Against Delta and Omicron in Mice
Jansen van Vuren, P.; McAuley, A. J.; Kuiper, M. J.; Singanallur, N. B.; Bruce, M. P.; Riddell, S.; Goldie, S.; Mangalaganesh, S.; Chahal, S.; Drew, T. W.; Blasdell, K. R.; Tachedjian, M.; Caly, L.; Druce, J. D.; Ahmed, S.; Khan, M. S.; Malladi, S. K.; Singh, R.; Pandey, S.; Varadarajan, R.; Vasan, S. S.
10.1101/2022.03.03.481940 — immunology — Posted on 2022-03-04
3599 Immunogenicity of an Ad26-based SARS-CoV-2 Omicron Vaccine in Naïve Mice and SARS-CoV-2 Spike Pre-immune Hamsters
Swart, M.; de Wilde, A.; Schmit-Tillemans, S.; Verspuij, J.; Daal, C.; Choi, Y.; Perkasa, A.; Kourkouta, E.; Tahiri, I.; Mulders, M.; Gil, A. I.; Muchene, L.; Juraszek, J.; Vellinga, J.; Custers, J.; Bos, R.; Schuitemaker, H.; Wegmann, F.; Roozendaal, R.; Kuipers, H.; Zahn, R.
10.1101/2022.03.04.482636 — immunology — Posted on 2022-03-04
3600 Not digested: algal glycans move carbon dioxide into the deep-sea
Vidal-Melgosa, S.; Lagator, M.; Sichert, A.; Priest, T.; Pätzold, J.; Hehemann, J.-H.
10.1101/2022.03.04.483023 — biochemistry — Posted on 2022-03-04
3601 Parallel Mechanosensory Systems are Required for Negative Gravitaxis in C. elegans
Ackley, C. R.; Ziaei Kajbaf, N.; Washiashi, L.; Krishnamurthy, R.; Joshi, P.; Rothman, J. H.
10.1101/2022.03.03.482913 — neuroscience — Posted on 2022-03-04
3606 Deep learning on reflectance confocal microscopy improves Raman spectral diagnosis of basal cell carcinoma
Chen, M.; Feng, X.; Fox, M. C.; Reichenberg, J. S.; Lopes, F. C. P. S.; Sebastian, K. R.; Markey, M. K.; Tunnell, J. W.
10.1101/2022.03.03.482837 — bioengineering — Posted on 2022-03-04
3607 Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25 by silkworm, Bombyx mori, and its biochemical analysis.
Miyata, T.; Minamihata, K.; Kurihara, K.; Kamizuru, Y.; Gotanda, M.; Obayashi, M.; Kitagawa, T.; Sato, K.; Kimura, M.; Oyama, K.; Ikeda, Y.; Tamaki, Y.; Lee, J. M.; Sakao, K.; Hamanaka, D.; Kusakabe, T.; Tachibana, M.; Ibrahim, H. H.
10.1101/2022.03.03.482736 — biochemistry — Posted on 2022-03-04
3615 Two new Rhizobiales species isolated from root nodules of common sainfoin (Onobrychis viciifolia) show different plant colonization strategies
Ashrafi, S.; Kuzmanovic, N.; Patz, S.; Lohwasser, U.; Bunk, B.; Sproeer, C.; Lorenz, M.; Fruehling, A.; Neumann-Schaal, M.; Verbarg, S.; Becker, M.; Thuenen, T.
10.1101/2022.03.04.482989 — microbiology — Posted on 2022-03-04
3616 Eukaryotic initiation factor 2α kinases regulate virulence functions, stage conversion, and the stress response in Entamoeba invadens
Walters, H. A.; Welter, B. H.; Orobio-Hurtado, R.; Moss, H. C.; Villano, M. A.; Sullivan, W. J.; Temesvari, L. A.
10.1101/2022.03.03.482935 — microbiology — Posted on 2022-03-04
3618 The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease
Movahed, E.; Vance, D. J.; Van Slyke, G.; Ehrbar, D.; Yates, J. L.; Kulas, K. E.; Rudolph, M. J.; Mantis, N. J.
10.1101/2022.03.03.482934 — immunology — Posted on 2022-03-04
3619 Periventricular nodular heterotopia is functionally coupled with the neocortex during resting and task states
Gao, Y.; Chen, G.; Teng, P.; Zhang, X.; Fang, F.; Englot, D. J.; Luan, G.; Wang, X.; Wang, Q.
10.1101/2022.03.03.482573 — neuroscience — Posted on 2022-03-04
3626 Pervasive Under-Dominance in Gene Expression as Unifying Principle of Biomass Heterosis in Arabidopsis
Yuan, W.; Beitel, F.; Srikant, T.; Bezrukov, I.; Schäfer, S.; Kraft, R.; Weigel, D.
10.1101/2022.03.03.482808 — genomics — Posted on 2022-03-04
3627 Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.
Murtha, K. E.; Yang, Y.; Ceriani, F.; Jeng, J.-Y.; Climer, L.; Jones, F.; Charles, J.; Devana, S.; Hornak, A.; Marcotti, W.; Simmons, D. D.
10.1101/2022.03.03.482327 — developmental biology — Posted on 2022-03-04
3628 Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
Wang, C.; Chen, C.; Liu, X.; Li, C.; Wu, Q.; Chen, X.; Yang, L.; Kou, X.; Zhao, Y.; Wang, H.; Gao, Y.; Zhang, Y.; Gao, S.
10.1101/2022.03.03.482916 — developmental biology — Posted on 2022-03-04
3631 The importance of m6A topology in chicken embryo mRNA; a precise mapping of m6A at the conserved chicken β-actin zipcode
Baron, F.; Zhang, M.; Archer, N.; Bellows, E.; Knight, H. M.; Welham, S.; Mongan, N. P.; Hayes, C. J.; Fray, R. G.; Bodi, Z.
10.1101/2022.03.04.483006 — molecular biology — Posted on 2022-03-04
3634 Neonatal Peyer's patch cDC activation as a pacemaker of postnatal immune maturation
Torow, N.; Li, R.; Hitch, T.; Mingels, C.; Al Bounny, S.; van Best, N.; Stange, E.-L.; Benabid, A.; Ruettger, L.; Gadermayr, M.; Runge, S.; Treichel, N.; Merhof, D.; Rosshart, S.; Jehmlich, N.; von Bergen, M.; Heymann, F.; Clavel, T.; Tacke, F.; Lelouard, H.; Costa, I. G.; Hornef, M. W.
10.1101/2022.03.03.482839 — immunology — Posted on 2022-03-04
3635 Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
D'Angeli, V.; Monzon-Casanova, E.; Matheson, L. S.; Gizlenci, O.; Petkau, G.; Gooding, C.; Berrens, R. V.; Smith, C. W. J.; Turner, M.
10.1101/2022.03.03.482829 — immunology — Posted on 2022-03-04
3636 Effects of dopamine D2 and opioid receptor antagonism on the trade-off between model-based and model-free behavior in healthy volunteers
Mikus, N.; Korb, S.; Massaccesi, C.; Gausterer, C.; Graf, I.; Willeit, M.; Eisenegger, C.; Lamm, C.; Silani, G.; Mathys, C.
10.1101/2022.03.03.482871 — neuroscience — Posted on 2022-03-04
3637 Ultrastructural analysis of wildtype and RIM1α knock-out active zones in a large cortical synapse
Lichter, K.; Paul, M.; Pauli, M.; Schoch, S.; Kollmannsberger, P.; Stigloher, C.; Heckmann, M.; Siren, A.-L.
10.1101/2022.03.04.482996 — neuroscience — Posted on 2022-03-04
3640 Control of contextual memory through interneuronal α5-GABAA receptors
Zhu, M.; Abdulzahir, A.; Perkins, M.; Krause, B.; Lennertz, R.; Ruhl, D.; Hentschke, H.; Nagarajan, R.; Chapman, E. R.; Rudolph, U.; Fanselow, M.; Pearce, R.
10.1101/2022.03.03.482912 — neuroscience — Posted on 2022-03-04
3641 Modernizing the NEURON Simulator for Sustainability, Portability, and Performance
Awile, O.; Kumbhar, P.; Cornu, N.; Dura-Bernal, S.; King, J. G.; Lupton, O.; Magkanaris, I.; McDougal, R. A.; Newton, A. J. H.; Pereira, F.; Savulescu, A.; Carnevale, N. T.; Lytton, W. W.; Hines, M. L.; Schürmann, F.
10.1101/2022.03.03.482816 — neuroscience — Posted on 2022-03-04
3642 An environmentally-responsive transcriptional state modulates cell identities during root development
Oliva, M.; Stuart, T.; Tang, D.; Pflueger, J.; Poppe, D.; Jabbari, J. S.; Gigante, S.; Dragwidge, J. M.; Whelan, J.; Lewsey, M. G.; Lister, R.
10.1101/2022.03.04.483008 — plant biology — Posted on 2022-03-04
3644 Zika virus persistence in the male macaque reproductive tract
Ball, E. E.; Pesavento, P. A.; Van Rompay, K. K. A.; Keel, M. K.; Singapuri, A.; Gomez-Vazquez, J. P.; Dudley, D. M.; OConnor, D.; Breitbach, M. E.; Maness, N.; Schouest, B.; Panganiban, A.; Coffey, L. L.
10.1101/2022.03.03.482872 — pathology — Posted on 2022-03-04
3650 Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model
Voss, L. F.; Howarth, A. J.; Wittenborn, T. R.; Hummelgaard, S.; Juul-Madsen, K.; Kastberg, K. S.; Pedersen, M. K.; Jensen, L.; Papanastasiou, A. D.; Vorup-Jensen, T.; Weyer, K.; Degn, S. E.
10.1101/2022.03.04.482991 — immunology — Posted on 2022-03-04
3657 Regional variation in cholinergic terminal activity determines the non-uniform occurrence of cortical slow-wave activity during REM sleep
Nazari, M.; Abadchi, J. K.; Naghizadeh, M.; Contreras, E. B.; Tatsuno, M.; McNaughton, B. L.; Mohajerani, M. H.
10.1101/2022.03.01.481863 — neuroscience — Posted on 2022-03-04
3661 CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen related receptor (ERR)driven oxidative metabolism in skeletal muscle
Barquissau, V.; Zanou, N.; Geller, S.; Castillo-Armengol, J.; Marzetta, F.; Huber, k.; Ziegler, D.; Lopez-Mejia, I.; Blanco Fernandez, J.; Roger, C.; Guex, N.; Preitner, F.; Vanacker, J. M.; Fajas, L.
10.1101/2022.03.03.482783 — physiology — Posted on 2022-03-04
3662 Recent Reconfiguration Of An Ancient Developmental Gene Regulatory Network In Heliocidaris Sea Urchins
Davidson, P. L.; Guo, H.; Swart, J. S.; Massri, A. J.; Edgar, A.; Wang, L.; Berrio, A.; Devens, H. R.; Koop, D.; Cisternas, P.; Zhang, H.; Zhang, Y.; Byrne, M.; Fan, G.; Wray, G. A.
10.1101/2022.03.03.482868 — evolutionary biology — Posted on 2022-03-04
3664 Helminth parasites decrease survival probability in young red deer
Acerini, C.; Morris, S.; Morris, A.; Kenyon, F.; McBean, D.; Pemberton, J.; Albery, G.
10.1101/2022.03.03.482858 — ecology — Posted on 2022-03-04
3666 SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis
Goyon, V.; Besse-Patin, A.; Zunino, R.; Nguyen, M.; Coyaud, E.; Lee, J. M.; Nguyen, B. N.; Raught, B.; McBride, H. M.
10.1101/2022.03.03.482848 — cell biology — Posted on 2022-03-04
3667 Oxidative stress profiles of lymphoblasts from Amyotrophic Lateral Sclerosis patients with or without known SOD1 Mutations
Cunha-Oliveira, T.; Silva, D. F.; Segura, L. G.; Baldeiras, I.; Marques, R.; Rosenstock, T.; Oliveira, P. J.; Silva, F. S. G.
10.1101/2022.03.03.482309 — cell biology — Posted on 2022-03-04
3668 p73 controls cell junction dynamics during sprouting angiogenesis and acts via Angiomotin
Maeso-Alonso, L.; Alonso-Olivares, H.; Martinez-Garcia, N.; Villoch-Fernandez, J.; Puente-Santamaria, L.; Colas-Algora, N.; Fernandez-Corona, A.; Lorenzo-Marcos, M. E.; Jimenez, B.; Holmgren, L.; Wilhelm, M.; Millan, J.; del Peso, L.; Claesson-Welsh, L.; Marques, M. M.; Marin, M. C.
10.1101/2022.03.03.482832 — cell biology — Posted on 2022-03-04
3671 MiR-182-5p regulates Nogo-A expression and promotes neurite outgrowth of hippocampal neurons in vitro
Soto, A.; Nieto-Diaz, M.; Reigada, D.; Munoz-Galdeano, T.; Barreda-Manso, M. A.; M. Maza, R.
10.1101/2022.03.03.482803 — neuroscience — Posted on 2022-03-04
3675 Aeration Strategy at Birth Does Not Impact Carotid Blood Flow and Oxygen Delivery in Preterm Lambs
Dahm, S.; Kenna, K.; Stewart, D.; Pereira-Fantini, P.; McCall, K.; Perkins, E.; Sourial, M.; Tingay, D.
10.1101/2022.03.03.482754 — physiology — Posted on 2022-03-04
3676 Bioluminescent zebrafish transplantation model for drug discovery
Hason, M.; Jovicic, J.; Vonkova, I.; Bojic, M.; Simon-Vermot, T.; White, R. M.; Bartunek, P.
10.1101/2022.03.03.482856 — pharmacology and toxicology — Posted on 2022-03-04
3677 Exploring the Neoantigen burden in Breast Carcinoma Patients
Animesh, S.; Ren, X.; An, O.; Chen, K.; Lee, S. C.; Yang, H.; Fullwood, M.
10.1101/2022.03.03.482669 — cancer biology — Posted on 2022-03-04
3687 A selective bottleneck during host entry drives the evolution of new legume symbionts
Doin De Moura, G. G.; Mouffok, S.; Gaudu, N.; Cazale, A.-C.; Milhes, M.; Bulach, T.; Valiere, S.; Roche, D.; Ferdy, J.-B.; Masson-Boivin, C.; Capela, D.; Remigi, P.
10.1101/2022.03.03.482760 — evolutionary biology — Posted on 2022-03-04
3688 Genomic compatibility excels possible 'good genes' effects of sexual selection in lake char
Garaud, L.; Nusbaumer, D.; de Guttry, C.; Ancay, L.; Jacquet, S.; Lasne, E.; Wedekind, C.
10.1101/2022.03.03.482834 — evolutionary biology — Posted on 2022-03-04
3690 Apical constriction induces tissue rupture in a proliferative epithelium
Osswald, M.; Barros-Carvalho, A.; Carmo, A. M.; Loyer, N.; Gracio, P. C.; Sunkel, C. E.; Homem, C. C.; Januschke, J.; Morais-de-Sa, E.
10.1101/2022.03.02.482459 — developmental biology — Posted on 2022-03-04
3691 A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage
Sarkar, G. C.; Rautela, U.; Goyala, A.; Datta, S.; Anand, N.; Singh, A.; Singh, P.; Chamoli, M.; Mukhopadhyay, A.
10.1101/2022.03.03.482777 — developmental biology — Posted on 2022-03-04
3695 Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer.
Hall, M. J.; Lopes-Ventura, S.; Neto, M. V.; Charneca, J.; Zoio, P.; Seabra, M. C.; Oliva, A.; Barral, D. C.
10.1101/2022.03.03.482849 — cell biology — Posted on 2022-03-04
3696 Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples
Karimi Abadchi, J.; Rezaei, Z.; Knöpfel, T.; McNaughton, B. L.; Mohajerani, M. H.
10.1101/2022.03.02.482726 — neuroscience — Posted on 2022-03-04
3697 An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
Avar, M.; Heinzer, D.; Thackray, A. M.; Liu, Y.; Hruska-Plochan, M.; Sellitto, S.; Schaper, E. W.; Pease, D. P.; Yin, J.-A.; Lakkaraju, A. K.; Emmenegger, M.; Losa, M.; Chincisan, A.; Hornemann, S.; Polymenidou, M.; Bujdoso, R.; Aguzzi, A.
10.1101/2022.03.03.482765 — neuroscience — Posted on 2022-03-04
3698 An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model
Peviani, M.; Das, S.; Patel, J.; Jno-Charles, O.; Kumar, R.; Zguro, A.; Mathews, T. D.; Milazzo, R.; Cavalca, E.; Poletti, V.; Biffi, A.
10.1101/2022.03.03.482460 — neuroscience — Posted on 2022-03-04
3699 EEG Responses to Auditory Figure-Ground Perception
Guo, X.; Dheerendra, P.; Benzaquen, E.; Sedley, W.; Griffiths, T. D.
10.1101/2022.03.03.482346 — neuroscience — Posted on 2022-03-04
3700 Concurrent TMS-fMRI to determine adaptive brain changes to virtual lesions interfering with visual processing
Raffin, E.; Salamanca-Giron, R. F.; Huxlin, K. R.; Reynaud, O.; Mattera, L.; Martuzzi, R.; Hummel, F.
10.1101/2022.03.03.482512 — neuroscience — Posted on 2022-03-04
3702 Alpha rhythm induces attenuation-amplification dynamics in neural activity cascades
Lombardi, F.; Herrmann, H. J.; Parrino, L.; Plenz, D.; Scarpetta, S.; Vaudano, A. E.; de Arcangelis, L.; Shriki, O.
10.1101/2022.03.03.482657 — neuroscience — Posted on 2022-03-04
3703 Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells
Yamoah, E. N.; Zhang, H.; Li, H.; Lu, M.; Wang, S.; Ma, X.; Wang, F.; Liu, J.; Li, X.; Yang, H.; Zhang, F.; Shen, H.; Buckley, N.; Gamper, N.; Lv, P.
10.1101/2022.03.03.482811 — neuroscience — Posted on 2022-03-04
3706 A Genome-Scale Metabolic Model for the Smut-Fungus Ustilago maydis
Liebal, U. W.; Ullmann, L.; Lieven, C.; Kohl, P.; Wibberg, D.; Zambanini, T.; Blank, L. M.
10.1101/2022.03.03.482780 — systems biology — Posted on 2022-03-04
3707 PIF4/HEMERA-mediated daytime thermosensory growth requires the Mediator subunit MED14
Qiu, Y.; Bajracharya, A.; Xi, J.; Grace, K. F.; Bayer, E. E.; Grant, C. A.; Clutton, C. H.; Baerson, S. R.; Agarwal, A.
10.1101/2022.03.02.482654 — plant biology — Posted on 2022-03-04
3708 Engineering bacterial blight-resistant plants through CRISPR/Cas9-targeted editing of the MeSWEET10a promoter in cassava
Wang, Y.; Geng, M.; Pan, R.; Zhang, T.; Zhen, X.; Che, Y.; Li, R.; Liu, J.; Chen, Y.; Guo, J.; Yao, Y.
10.1101/2022.03.02.482644 — plant biology — Posted on 2022-03-04
3709 Gene Expression and Tracer-Based Metabolic Flux Analysis Reveals Tissue-Specific Metabolic Scaling in vitro, ex vivo, and in vivo
Akingbesote, N. D.; Leitner, B. P.; Jovin, D. G.; Desrouleaux, R.; Zhu, W.; Li, Z.; Pollak, M. N.; Perry, R. J.
10.1101/2022.03.02.482685 — physiology — Posted on 2022-03-04
3711 Defining cellular population dynamics at single cell resolution during prostate cancer progression
Germanos, A. A.; Arora, S.; Zheng, Y.; Goddard, E. T.; Coleman, I. M.; Ku, A. T.; Wilkinson, S.; Amezquita, R. A.; Zager, M.; Long, A.; Yang, Y. C.; Bielas, J. H.; Gottardo, R.; Ghajar, C. M.; Nelson, P. S.; Sowalsky, A. G.; Setty, M.; Hsieh, A. C.
10.1101/2022.03.02.482711 — cancer biology — Posted on 2022-03-04
3714 Optimization of dynamic soaring in a flap-gliding seabird and its impacts on large-scale distribution at sea
Kempton, J. A.; Wynn, J.; Bond, S.; Evry, J.; Fayet, A. L.; Gillies, N.; Guilford, T.; Kavelaars, M.; Juarez-Martinez, I.; Padget, O.; Rutz, C.; Shoji, A.; Syposz, M.; Taylor, G. K.
10.1101/2022.03.03.482753 — animal behavior and cognition — Posted on 2022-03-04
3717 Large haploblocks underlie rapid adaptation in an invasive weed
Battlay, P.; Wilson, J.; Bieker, V. C.; Lee, C.; Prapas, D.; Petersen, B.; Craig, S.; van Boheemen, L.; Scalone, R.; de Silva, N. P.; Sharma, A.; Konstantinovic, B.; Nurkowski, K. A.; Rieseberg, L. H.; Connallon, T.; Martin, M. D.; Hodgins, K. A.
10.1101/2022.03.02.482376 — evolutionary biology — Posted on 2022-03-04
3718 Rpadrino: an R package to access and use PADRINO, an open access database of Integral Projection Models
Levin, S. C.; Evers, S.; Potter, T.; Pena-Guerrero, M.; Childs, D. Z.; Compagnoni, A.; Knight, T.; Salguero-Gomez, R.
10.1101/2022.03.02.482673 — ecology — Posted on 2022-03-04
3724 A structural atlas of the developing zebrafish telencephalon based on spatially-restricted transgene expression
Turner, K. J.; Hawkins, T. A.; Henriques, P. M.; Valdivia, L. E.; Bianco, I. H.; Wilson, S. W.; Folgueira, M.
10.1101/2022.03.02.482259 — neuroscience — Posted on 2022-03-04
3725 Connectomic Analysis of the Drosophila Lateral Neuron Clock Cells Reveals the Synaptic Basis of Functional Pacemaker Classes.
Shafer, O. T.; Gutierrez, G. J.; Li, K.; Mildenhall, A.; Spira, D.; Marty, J.; Lazar, A. A.; Fernandez, M. d. l. P.
10.1101/2022.03.02.482743 — neuroscience — Posted on 2022-03-04
3728 A comprehensive single-cell expression atlas of human AML leukemia-initiating cells unravels the contribution of HIF pathway and its therapeutic potential
Velasco-Hernandez, T.; Trincado, J. L.; Vinyoles, M.; Closa, A.; Gutierrez-Aguera, F.; Molina, O.; Rodriguez-Cortez, V. C.; Petazzi, P.; Beneyto-Calabuig, S.; Velten, L.; Romecin, P.; Casquero, R.; Abollo-Jimenez, F.; Diaz de la Guardia, R.; Lorden, P.; Bataller, A.; Lapillonne, H.; Stam, R. W.; Vives, S.; Torrebadell, M.; Fuster, J. L.; Bueno, C.; Eyras, E.; Heyn, H.; Menendez, P.
10.1101/2022.03.02.482638 — cancer biology — Posted on 2022-03-04
3730 Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Herbst, S. A.; Vesterlund, M.; Helmboldt, A. J.; Jafari, R.; Siavelis, I.; Stahl, M.; Schitter, E.; Liebers, N.; Brinkmann, B.; Czernilofsky, F.; Roider, T.; Bruch, P.-M.; Iskar, M.; Kittai, A.; Huang, Y.; Lu, J.; Richter, S.; Mermelekas, G.; Umer, H. M.; Knoll, M.; Kolb, C.; Lenze, A.; Cao, X.; Oesterholm, C.; Wahnschaffe, L.; Herling, C.; Scheinost, S.; Ganzinger, M.; Mansouri, L.; Kriegsmann, K.; Kriegsmann, M.; Anders, S.; Zapatka, M.; Del Poeta, G.; Zucchetto, A.; Bomben, R.; Gattei, V.; Dreger, P.; Woyach, J.; Herling, M.; Mueller-Tidow, C.; Rosenquist, R.; Stilgenbauer, S.; Zenz, T.; Hu
10.1101/2022.03.01.481539 — cancer biology — Posted on 2022-03-04
3733 Uneven terrain treadmill walking in younger and older adults
Downey, R. J.; Richer, N.; Gupta, R.; Liu, C.; Pliner, E. M.; Roy, A.; Hwang, J.; Clark, D. J.; Hass, C. J.; Manini, T. M.; Seidler, R. D.; Ferris, D. P.
10.1101/2022.03.01.482507 — bioengineering — Posted on 2022-03-04
3736 A chromosome-level genome assembly enables the identification of the follicle stimulating hormone receptor as the master sex determining gene in Solea senegalensis
De la Herran, R.; Hermida, M.; Rubiolo, J. A.; Gomez-Garrido, J.; Cruz, F.; Navajas, R.; Blanco, A.; Villamayor, P. R.; Torres, D.; Sanchez-Quinteiro, P.; Ramirez, D.; Rodriguez, M. E.; Arias-Perez, A.; Cross, I.; Duncan, N. J.; Martinez-Pena, T.; Riaza, A.; Millan, A.; Gut, M. J.; Bouza, C.; Robledo, D.; Rebordinos, L.; Alioto, T.; Ruiz-Rejon, C.; Martinez, P.
10.1101/2022.03.02.482245 — genomics — Posted on 2022-03-04
3742 In vivo assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy
Riquelme-Guzman, C.; Beck, T.; Edwards-Jorquera, S.; Schlüssler, R.; Müller, P.; Guck, J.; Möllmert, S.; Sandoval-Guzman, T.
10.1101/2022.03.01.482501 — developmental biology — Posted on 2022-03-04
3744 NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance
Yang, J.-M.; Ren, Y.; Kumar, A.; Xiong, X.; das, j.; Peng, H.-y.; Wang, L.; Ren, X.; Alainz, R. C.; de Figueiredo, P.; Fang, D.; Liu, X.; Wang, J.; Song, J. J.
10.1101/2022.03.01.482525 — immunology — Posted on 2022-03-04
3745 Visual Perception of 3D Space and Shape in Time - Part III: 2D Shape Recognition by Log-Scaling
Ta, B.; Silva, M. E. M. M.; Bartlett, K.; Afifa, U.; Agazaryan, A.; Canela, R.; Carmona, J.; De Leon, E. J. L.; Drost, A.; Espino, D.; Espinoza, G.; Follis, K.; Gan, P.; Ho, L.; Honore, C.; Huang, E.; Ibarra, L.; Jackson, T.; Khosla, M.; Le, C.; Li, V.; McCarthy, T.; Mills, E.; Mohapatra, S.; Morishige, Y.; Nguyen, N.; Peng, Z.; Peyvan, K.; Phipps, M.; Poschl, I.; Rangarajan, J.; Santos, C.; Schummer, L.; Shi, S.; Smale, N.; Smith, A.; Sood, D.; Ta, C.; Tran, A.; Tran, M.; Wang, R.; Wilson, P.; Yang, N. L.; Yu, M.; Yu, S.; Blaisdell, A. P.; Arisaka, K.
10.1101/2022.03.01.482004 — neuroscience — Posted on 2022-03-04
3746 Cross-comparison of state of the art neuromorphological simulators on modern CPUs and GPUs using the Brain Scaffold Builder
De Schepper, R. G.; Abi Akar, N.; Hater, T.; Huisman, B. F.; D'Angelo, E. U.; Morrison, A.; Casellato, C.
10.1101/2022.03.02.482285 — neuroscience — Posted on 2022-03-04
3749 Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays
Flynn, R.; Washer, S.; Jeffries, A. R.; Andrayas, A.; Shireby, G.; Kumari, M.; Schalkwyk, L. C.; Mill, J.; Hannon, E.
10.1101/2022.03.01.482537 — neuroscience — Posted on 2022-03-04
3750 Dopaminergic modulation of dynamic emotion perception
Schuster, B. A.; Sowden, S.; Rybicki, A. J.; Fraser, D. S.; Press, C.; Holland, P.; Cook, J. L.
10.1101/2022.03.02.482469 — neuroscience — Posted on 2022-03-04
3751 Intracranial EEG spectral feature analysis and focal brain stimulation reveal affective specialization within dorsal anterior cingulate cortex
Metzger, B. A.; Kalva, P.; Mocchi, M. M.; Cui, B.; Adkinson, J. A.; Wang, Z.; Mathura, R.; Gavvala, J.; Krishnan, V.; Lin, L.; Maheshwari, A.; Shofty, B.; Sheth, S. A.; Bijanki, K. C. R.
10.1101/2022.03.01.482354 — neuroscience — Posted on 2022-03-04
3752 The influence of movement-related costs when searching to act and acting to search
Moskowitz, J. B.; Berger, S. A.; Castelhano, M. S.; Gallivan, J. P.; Flanagan, J. R.
10.1101/2022.03.01.482521 — neuroscience — Posted on 2022-03-04
3755 Visual Perception of 3D Space and Shape In Time - Part IV: 3D Shape Recognition by 3D Rotation
Le, C. T.; Pedersen, S.; Chan, J.; Chen, N.; Ta, B.; Wilson, P.; McCarthy, T.; Barseghyan, E.; Chauhan, A.; Saif, H.; Tu, J.; Wijaya, D. J.; Zhang, A.; Li, E.; Marangi, C.; Nekarae, S.; Wang, F.; Yanovsky, A.; Afifa, U.; Carmona, J.; Espino, D.; Schummer, L.; Gudijanto, P. A.; Kaur, G.; Lam, A.; Mar, M.; Mills, E.; Nevins, A.; Ortiz, E.; Wheeler, K.; Blaisdell, A.; Arisaka, K.
10.1101/2022.03.01.482164 — neuroscience — Posted on 2022-03-04
3756 Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain
Lemaitre, P.; Tareen, S.; Pasciuto, E.; Mascali, L.; Martirosyan, A.; Callaerts-Vegh, Z.; Dooley, J.; Holt, M.; Yshii, L.; Liston, A.
10.1101/2022.03.01.482519 — neuroscience — Posted on 2022-03-04
3758 A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment
Boutzen, H.; Chan-Seng-Yue, M.; Murison, A.; Mbong, N.; Wagenblast, E.; Arlidge, C.; Madani Tonekaboni, S. A.; Orouji, E.; Arruda, A.; Mitchell, A.; Notta, F.; Lupien, M.; Minden, M.; Kaufmann, K.; Dick, J.
10.1101/2022.03.01.482535 — cancer biology — Posted on 2022-03-04
3760 Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic niches
Sattiraju, A.; Kang, S.; Chen, Z.; Marallano, V.; Brusco, C.; Ramakrishnan, A.; Shen, L.; Hambardzumyan, D.; Friedel, R.; Zou, H.
10.1101/2022.03.01.482530 — cancer biology — Posted on 2022-03-04
3761 Creating a 'Timeline' of ductal carcinoma in situ to identify processes and biomarkers for progression towards invasive ductal carcinoma
Rebbeck, C. A.; Xian, J.; Bornelov, S.; Geradts, J.; Hobeika, A.; Geiger, H.; Alvarez, J. F.; Rozhkova, E.; Nicholls, A.; Robine, N.; Lyerly, H. K.; Hannon, G. J.
10.1101/2022.03.01.482529 — cancer biology — Posted on 2022-03-04
3766 Macro-Chemical Biology: Engineering Biomimetic Trogocytosis with Farnesylated Chemically Self-Assembled Nanorings
Wang, Y.; Rozumalski, L.; Lichtenfels, C.; Petersburg, J.; Kilic, O.; Distefano, M.; Wagner, C. R.
10.1101/2022.03.01.482559 — bioengineering — Posted on 2022-03-04
3767 Deconstructing a visual signal: the role of motion and colour in predator deterrence
Rao, D.; Long, S. M.; Tapia-McClung, H.; Salgado-Espinosa, K.; Narendra, A.; Aguilar-Arguello, S. O.; Robledo-Ospina, L. E.; Rodriguez-Morales, D.; Jakob, E.
10.1101/2022.03.01.482534 — animal behavior and cognition — Posted on 2022-03-04
3769 Comprehensive analysis of cis- and trans-acting factors affecting Break-Induced Replication
Uribe-Calvillo, T.; Maestroni, L.; Marsolier, M.-C.; Khadaroo, B.; Arbiol, C.; Jonathan, S.; Llorente, B.
10.1101/2022.03.02.482614 — genetics — Posted on 2022-03-04
3770 Rapid and transient evolution of local adaptation to seasonal host fruits in an invasive fly
Olazcuaga, L.; Foucaud, J.; Deschamps, C.; Loiseau, A.; Claret, J.-L.; Vedovato, R.; Guilhot, R.; Sevely, C.; Gautier, M.; Hufbauer, R. A.; Rode, N. O.; Estoup, A.
10.1101/2022.03.01.482503 — evolutionary biology — Posted on 2022-03-04
3772 Global ecological and biogeochemical impacts of pelagic tunicates
Luo, J. Y.; Stock, C. A.; Henschke, N.; Dunne, J. P.; O'Brien, T. D.
10.1101/2022.03.01.482560 — ecology — Posted on 2022-03-04
3773 IgG1 responses following SARS-CoV-2 infection are polyclonal and highly personalized, whereby each donor and each clone displays a distinct pattern of cross-reactivity against SARS-CoV-2 variants
van Rijswijck, D. M. H.; Bondt, A.; Hoek, M.; van der Straten, K.; Caniels, T. G.; Poniman, M.; Eggink, D.; Reusken, C. B. E. M.; de Bree, G. J.; Sanders, R. W.; van Gils, M.; Heck, A. J. R.
10.1101/2022.02.24.481778 — immunology — Posted on 2022-03-04
3776 EMC10 reduction in human neurons and adult mouse brain rescues cellular and behavioral deficits linked to 22q11.2 deletion
Thakur, P.; Lackinger, M.; Diamantopoulou, A.; Rao, S.; Chen, Y.; Ferng, A.; Mazur, C.; Kordasiewicz, H.; Shprintzen, R. J.; Markx, S.; Xu, B.; Gogos, J. A.
10.1101/2022.03.01.482495 — neuroscience — Posted on 2022-03-04
3777 Soluble ECM promotes organotypic formation in lung alveolar model
Valdoz, J. C.; Franks, N. A.; Cribbs, C. G.; Jacobs, D. J.; Dodson, E. L.; Knight, C. J.; Poulson, P. D.; Garfield, S. R.; Johnson, B. C.; Hemeyer, B. M.; Sudo, M. T.; Saunooke, J. A.; Kartchner, B. C.; Saxton, A.; Vallecillo-Zuniga, M. L.; Santos, M.; Chamberlain, B.; Christensen, K. A.; Nordin, G. P.; Narayanan, A. S.; Raghu, G.; Van Ry, P. M.
10.1101/2021.09.16.460165 — bioengineering — Posted on 2022-03-04
3782 A gut-derived hormone switches dietary preference after mating in Drosophila
Malita, A.; Kubrak, O.; Koyama, T.; Ahrentloev, N.; Halberg, K. V.; Texada, M. J.; Nagy, S.; Rewitz, K.
10.1101/2022.03.02.482605 — animal behavior and cognition — Posted on 2022-03-04
3784 SlS5H silencing reveals specific pathogen-triggered salicylic acid metabolism in tomato
Paya, C.; Minguillon, S.; Hernandez-Carretero, M.; Miguel, S.; Campos, L.; Rodrigo, I.; Belles, J. M.; Lopez-Gresa, M. P.; Lison, P.
10.1101/2022.03.03.482652 — biochemistry — Posted on 2022-03-04
3786 Stepwise evolution of a butterfly supergene via duplication and inversion
Kim, K.-W.; De-Kayne, R.; Gordon, I. J.; Omufwoko, K. S.; Martins, D. J.; ffrench-Constant, R.; Martin, S. H.
10.1101/2021.12.06.471392 — evolutionary biology — Posted on 2022-03-04
3787 Determining the optimal SARS-CoV-2 mRNA vaccine dosing interval for maximum immunogenicity
Asamoah-Boaheng, M.; Goldfarb, D. M.; Prusinkiewicz, M.; Golding, L.; Karim, M. E.; Barakauskas, V.; Wall, N.; Jassem, A. N.; Marquez, A. C.; MacDonald, C.; O'Brien, S. F.; Lavoie, P.; Grunau, B.
10.1101/2022.03.01.482592 — microbiology — Posted on 2022-03-04
3790 Activation of the type 3 secretion system of enteropathogenic E. coli leads to remodeling of its membrane composition and function
Zacharia, A.; Pal, R. R.; Katsowich, N.; Mannully, C. T.; ibrahim, a.; Alfandary, S.; Serruya, R.; Baidya, A.; Ben-Yehuda, S.; Rosenshine, I.; Moussaieff, A.
10.1101/2020.12.17.423234 — systems biology — Posted on 2022-03-04
3791 Vicia faba TPC1, a genetically encoded variant of the vacuole Two Pore Channel 1, is hyperexcitable
Lu, J.; Dreyer, I.; Dickinson, M. S.; Panzer, S.; Jaslan, D.; Navarro-Retamal, C.; Geiger, D.; Terpitz, U.; Becker, D.; Stroud, R. M.; Marten, I.; Hedrich, R.
10.1101/2021.12.22.473873 — plant biology — Posted on 2022-03-04
3794 What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine
Gnanadesikan, G. E.; Hammock, E. A. D.; Tecot, S. R.; Lewis, R. J.; Hart, R.; Carter, C. S.; MacLean, E. L.
10.1101/2022.03.03.482682 — neuroscience — Posted on 2022-03-04
3796 Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space
Warrington, S.; Thompson, E.; Bastiani, M.; Dubois, J.; Baxter, L.; Slater, R.; Jbabdi, S.; Mars, R. B.; Sotiropoulos, S. N.
10.1101/2022.03.03.482776 — neuroscience — Posted on 2022-03-04
3797 Single-cell Spatial Proteomic Imaging for Human Neuropathology
Vijayaragavan, K.; Cannon, B. J.; Tebaykin, D.; Bosse, M.; Baranski, A.; Oliveria, J.; Mrdjen, D.; Corces, R.; McCaffrey, E. F.; Greenwald, N.; Sigal, Y.; Khair, Z.; Bruce, T.; Bharadwaj, A.; Bukhari, S.; Montine, K.; Angelo, M.; Montine, T.; Bendall, S. C.
10.1101/2022.03.02.482730 — systems biology — Posted on 2022-03-04
3801 Using machine learning to understand microgeographic determinants of the Zika vector, Aedes aegypti
Alexander, J.; Wilke, A. B. B.; Mantero, A.; Vasquez, C.; Petrie, W.; Kumar, N.; Beier, J. C.
10.1101/2022.03.03.482880 — ecology — Posted on 2022-03-03
3803 Functional and effective connectivity between dorsolateral prefrontal and subgenual anterior cingulate cortex depends on the timing of transcranial magnetic stimulation relative to the phase of prefrontal alpha EEG
Pantazatos, S. P.; McIntosh, J. R.; Saber, G. T.; Sun, X.; Doose, J.; Faller, J.; Lin, Y.; Teves, J. B.; Blankenship, A.; Huffman, S.; Goldman, R. I.; George, M. S.; Sajda, P.; Brown, T.
10.1101/2022.02.14.480466 — neuroscience — Posted on 2022-03-03
3804 Cellular and Circuit Organization of the Locus Coeruleus of Adult Mice
McKinney, A.; Hu, M.; Jing, J.; Hoskins, A.; Mohammadyar, A.; Naeem, N.; Patel, S.; Sheth, B. R.; Jiang, X.
10.1101/2022.03.01.481656 — neuroscience — Posted on 2022-03-03
3811 Quantitative analysis of gene expression on the inactive human X chromosome
San Roman, A. K.; Godfrey, A. K.; Skaletsky, H.; Bellott, D. W.; Groff, A. F.; Harris, H. L.; Blanton, L. V.; Hughes, J. F.; Brown, L.; Phou, S.; Buscetta, A.; Kruszka, P.; Banks, N.; Dutra, A.; Pak, E.; Lasutschinkow, P. C.; Keen, C.; Davis, S. M.; Tartaglia, N. R.; Samango-Sprouse, C.; Muenke, M.; Page, D. C.
10.1101/2021.08.09.455676 — genetics — Posted on 2022-03-03
3812 PCYT2 controls muscle health and muscle aging
Cikes, D.; Elsayad, K.; Sezgin, E.; Koitai, E.; Ferenc, T.; Orthofer, M.; Yarwood, R.; Heinz, L.; Sedlyarov, V.; Darwish-Miranda, N.; Taylor, A.; Grapentine, S.; al-Murshedi, F.; Abot, A.; Weidinger, A.; Kutchukian, C.; Sanchez, C.; Cronin, S. J. F.; Novatchkova, M.; Kavirayani, A.; Schuetz, T.; Haubner, B.; Haas, L.; Hagelkrueys, A.; Jackowski, S.; Kozlov, A.; Jacquemond, V.; Knauf, C.; Superti-Furga, G.; Rullman, E.; Gustafsson, T.; McDermott, J. H.; Lowe, M. P.; Radak, Z.; Chamberlain, J. S.; Bakovic, M.; Banka, S.; Penninger, J.
10.1101/2022.03.02.482658 — genetics — Posted on 2022-03-03
3815 Deciphering the potential niche of two novel black yeast fungi from a biological soil crust based on their genomes, phenotypes, and melanin regulation
Carr, E. C.; Barton, Q.; Grambo, S.; Renfro, C.; Sullivan, M. T.; Kuo, A.; Pangilinan, J.; Lipzen, A.; Keymanesh, K.; Savage, E.; Barry, K.; Grigoriev, I. V.; Riekhof, W. R.; Harris, S. D.
10.1101/2021.12.03.471027 — microbiology — Posted on 2022-03-03
3818 Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche
Papalazarou, V.; Drew, J.; Juin, A.; Spence, H. J.; Nixon, C.; Salmeron-Sanchez, M.; Machesky, L. M.
10.1101/2022.03.03.482797 — cancer biology — Posted on 2022-03-03
3819 The chromatin regulator HMGA1a undergoes phase separation in the nucleus
Zhu, H.; Narita, M.; Joseph, J. A.; Krainer, G.; Arter, W. E.; Saar, K. L.; Ermann, N.; Espinosa, J. R.; Shen, Y.; Kuri, M. A.; Qi, R.; Xu, Y.; Collepardo-Guevara, R.; Narita, M.; Knowles, T.
10.1101/2021.10.14.464384 — biophysics — Posted on 2022-03-03
3829 Nutrient-dependent regulation of β-cell KATP channels is controlled by the isoforms of pyruvate kinase and the source of phosphoenolpyruvate
Foster, H. R.; Ho, T.; Potapenko, E.; Sdao, S. M.; Lewandowski, S. L.; VanDeusen, H. R.; Davidson, S. M.; Cardone, R. L.; Kibbey, R. G.; Merrins, M. J.
10.1101/2022.02.09.478817 — cell biology — Posted on 2022-03-03
3831 Rapid single-molecule characterisation of nucleic-acid enzymes
Mueller, S. H.; Fitschen, L. J.; Shirbini, A.; Hamdan, S. M.; Spenkelink, L. M.; van Oijen, A. M.
10.1101/2022.03.03.482895 — biophysics — Posted on 2022-03-03
3832 Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury
Tan, C.; Norden, P. R.; Liu, T.; Ujiie, N.; Yan, X.; Aoto, K.; Ortega, S.; De Plaen, I. G.; Kume, T.
10.1101/2022.03.03.482713 — molecular biology — Posted on 2022-03-03
3833 Stress promotes RNA G-quadruplex folding in human cells
Kharel, P.; Fay, M.; Manasova, E.; Anderson, P.; Kurkin, A.; Guo, J.; Ivanov, P.
10.1101/2022.03.03.482884 — molecular biology — Posted on 2022-03-03
3834 TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance
Yang, A.; Bofill-De Ros, X.; Stanton, R.; Shao, T.-j.; Villanueva, P.; Gu, S.
10.1101/2022.03.03.482894 — molecular biology — Posted on 2022-03-03
3835 Live-cell imaging and physical modeling reveal control of chromosome folding dynamics by cohesin and CTCF
Mach, P.; Kos, P. I.; Zhan, Y.; Cramard, J.; Gaudin, S.; Tuennermann, J.; Marchi, E.; Eglinger, J.; Zuin, J.; Kryzhanovska, M.; Smallwood, S.; Gelman, L.; Roth, G.; Nora, E. P.; Tiana, G.; Giorgetti, L.
10.1101/2022.03.03.482826 — molecular biology — Posted on 2022-03-03
3840 Taxonomic and functional shifts in the perinatal gut microbiome of rhesus macaques
Rhoades, N. S.; Cinco, I. R.; Hendrickson, S. M.; Slifka, M. K.; Messaoudi, I.
10.1101/2022.03.02.482686 — microbiology — Posted on 2022-03-03
3842 Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal
Krill-Burger, J. M.; Dempster, J. M.; Borah, A. A.; Paolella, B. R.; Root, D. E.; Golub, T. R.; Boehm, J. S.; Hahn, W.; McFarland, J. M.; Vazquez, F.; Tsherniak, A.
10.1101/2022.03.02.482624 — cancer biology — Posted on 2022-03-03
3843 Structural basis of flagellar filament asymmetry and supercoil templating by Leptospira spirochete sheath proteins
Brady, M. R.; San Martin, F.; Debs, G. E.; Gibson, K. H.; Rodriguez, A.; Duran, R.; Wunder, E.; Ko, A.; Buschiazzo, A.; Sindelar, C. V.
10.1101/2022.03.03.482903 — biophysics — Posted on 2022-03-03
3844 Roles of the second-shell amino acid R266 in other members of the MLE subgroup of the enolase superfamily
Truong, D. P.; Fults, S.; Davila, C.; Huddleston, J. P.; Brock, D.; Zhu, M.; Pellois, J.-P.; Hull, K. G.; Romo, D.; Raushel, F. M.; Glasner, M. E.
10.1101/2022.03.03.481873 — biochemistry — Posted on 2022-03-03
3845 Development of a Method Combining Peptidiscs and Proteomics to Identify, Stabilize and Purify a Detergent-Sensitive Membrane Protein Assembly
Young, J. W.; Wason, I. S.; Zhao, Z.; Kim, S.; Aoki, H.; Phanse, S.; Rattray, D. G.; Foster, L. J.; Babu, M.; Duong, F.
10.1101/2022.03.03.482899 — biochemistry — Posted on 2022-03-03
3850 Soluble signal inhibitory receptor on leukocytes-1 is released from activated neutrophils by proteinase 3 cleavage
von Richthofen, H. J.; Westerlaken, G. H. A.; Gollnast, D.; Besteman, S.; Delemarre, E. M.; Rodenburg, K.; Moerer, P.; Stapels, D. A. C.; Andiappan, A. K.; Rotzschke, O.; Nierkens, S.; Leavis, H. L.; Bont, L. J.; Rooijakkers, S. H. M.; Meyaard, L.
10.1101/2022.03.03.482795 — immunology — Posted on 2022-03-03
3851 Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.
Box, H. J.; Pennington, S. H.; Kijack, E.; Tatham, L.; Caygill, C. H.; Lopeman, R. C.; Jeffreys, L. N.; Herriott, J.; Sharp, J.; Neary, M.; Valentijn, A.; Pertinez, H.; Curley, P.; Arshad, U.; Rajoli, R. K.; Rannard, S.; Stewart, J. P.; Biagini, G.; Owen, A.
10.1101/2022.03.03.482788 — pharmacology and toxicology — Posted on 2022-03-03
3852 LCK Regulates Homologous Recombination DNA Repair Identifying a New Therapeutic Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer
Dey, G.; Bharti, R.; Braley, C.; Alluri, R.; Esakov, E.; Crean-Tate, K.; McCrae, K.; Joehlin-Price, A.; Rose, P. G.; Lathia, J.; Gong, Z.; Reizes, O.
10.1101/2021.03.03.433791 — cancer biology — Posted on 2022-03-03
3853 Amplification of Olfactory Signals by Anoctamin 9 is Essential for Mammalian Olfaction: a Risk Factor for the Covid-19-associated Anosmia
Kim, H.; Kim, H.; Nguyen, L. T.; Ha, T.; Lim, S.; Kim, K.; Kim, S. H.; Han, K.; Hyeon, S. J.; Ryu, H.; Park, Y. S.; Kim, S. H.; Kim, I.-B.; Hong, G.-S.; Lee, S. E.; Choi, Y.; Cohen, L. B.; Oh, U.
10.1101/2022.03.02.482745 — cell biology — Posted on 2022-03-03
3858 APOEϵ4 and exercise interact to influence systemic and cerebral risk factors for dementia
Foley, K. E.; Diemler, C. A.; Hewes, A. A.; Garceau, D. T.; Sasner, M.; Howell, G. R.
10.1101/2022.03.01.480612 — genetics — Posted on 2022-03-03
3860 Machine learning-aided multidimensional phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons
Vuidel, A.; Cousin, L.; Weykopf, B.; Haupt, S.; Hanifehlou, Z.; Wiest-Daessle, N.; Segschneider, M.; Peitz, M.; Ogier, A.; Brino, L.; Brüstle, O.; Sommer, P.; Wilbertz, J. H.
10.1101/2022.03.01.482490 — neuroscience — Posted on 2022-03-03
3861 Regional variation in cholinergic terminal activity determines the non-uniform occurrence of cortical slow-wave activity during REM sleep
Nazari, M.; Abadchi, J. K.; Naghizadeh, M.; Contreras, E. B.; Tatsuno, M.; McNaughton, B. L.; Mohajerani, M. H.
10.1101/2022.03.01.481863 — neuroscience — Posted on 2022-03-03
3867 Spatiotemporal changes in genetic diversity and structure of a recent fish invasion in eastern North America
Bernos, T.; Avlijas, S.; Hill, J.; Morissette, O.; Ricciardi, A.; Mandrak, N.; Jeffries, K.
10.1101/2022.03.01.482476 — genomics — Posted on 2022-03-03
3868 Symbiosis with rhizobia limits range expansion only in polyploid legumes
Parshuram, Z.; Harrison, T. L.; Simonsen, A.; Stinchcombe, J. R.; Frederickson, M.
10.1101/2022.03.01.482489 — evolutionary biology — Posted on 2022-03-03
3869 Environmental thresholds in the functional mycobiome of global drylands
Egidi, E.; Delgado-Baquerizo, M.; Berdugo, M.; Guirado, E.; Albanese, D.; Singh, B. K.; COLEINE, C.
10.1101/2022.03.01.482255 — ecology — Posted on 2022-03-03
3871 Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry
Stajkovic, N.; Liu, Y.; Arsic, A.; Meng, N.; Lyu, H.; Zhang, N.; Grimm, D.; Lerche, H.; Nikic-Spiegel, I.
10.1101/2022.03.01.480798 — neuroscience — Posted on 2022-03-03
3872 Magnetoencephalography can reveal deep brain network activities linked to memory processes
Lopez-Madrona, V. J.; Medina Villalon, S.; Badier, J.-M.; Trebuchon, A.; Jayabal, V.; Bartolomei, F.; Carron, R.; Barborica, A.; Vulliemoz, S.; Alario, F. X.; Benar, C. G.
10.1101/2022.02.28.482228 — neuroscience — Posted on 2022-03-03
3876 Hidden dynamics of proteasome autoregulation discovered by cryo-EM data-driven deep learning
Wu, Z.; Chen, E.; Zhang, S.; Wang, W. L.; Ma, Y.; Dong, Y.; Liu, C.; Yin, C.-C.; Mao, Y.
10.1101/2020.12.22.423932 — biochemistry — Posted on 2022-03-03
3878 Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3
Ma, H.; Tseng, C.-T. K.; Zong, H.; Liao, Y.; Ke, Y.; Tang, H.; Wang, L.; Wang, Z.; He, Y.; Chang, Y.; Wang, S.; Drelich, A.; Hsu, J.; Tat, V.; Yuan, Y.; Wu, M.; Liu, J.; Yue, Y.; Xu, W.; Zhang, X.; Wang, Z.; Yang, L.; Chen, H.; Bian, Y.; Zhang, B.; Yin, H.; Chen, Y.; Zhang, E.; Zhang, X.; Gilly, J.; Sun, T.; Han, L.; Xie, Y.; Jiang, H.; Zhu, J.
10.1101/2022.02.25.482049 — cell biology — Posted on 2022-03-03
3880 Biofilm matrix proteome of clinical strain of P. aeruginosa
Egorova, D. A.; Solovyev, A. I.; Polyakov, N. B.; Danilova, K. V.; Scherbakova, A. A.; Kravtsov, I. N.; Dmitrieva, M. A.; Rykova, V. S.; Tutykhina, I. L.; Romanova, Y. M.; Gintsburg, A. L.
10.1101/2021.12.21.473640 — microbiology — Posted on 2022-03-03
3885 Earliest evidence for frugivory and seed dispersal by birds
Hu, H.; Wang, Y.; McDonald, P. G.; Wroe, S.; O'Connor, J. K.; Bjarnason, A.; Bevitt, J. J.; Yin, X.; Zheng, X.; Zhou, Z.; Benson, R. B.
10.1101/2022.03.01.482456 — paleontology — Posted on 2022-03-03
3888 Speeded Inference Game: Opening a new chapter in the assessment of error awareness
Niessen, E.; Wickert, J.; Schober, M.; Fink, G. R.; Stahl, J.; Weiss, P. H.
10.1101/2022.03.01.481617 — neuroscience — Posted on 2022-03-03
3891 Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG
Mbah, N.; Myers, A.; Chung, C.; Thompson, J.; Hong, H.; Sajjakulnukit, P.; Nwosu, Z.; Shan, M.; Sweha, S.; Maydan, D.; Chen, B.; Zhang, L.; Magnuson, B.; Zui, Z.; Wahl, D.; Franchi, L.; Agnihotri, S.; Koschmann, C.; Venneti, S.; Lyssiotis, C. A.
10.1101/2022.03.01.482555 — cancer biology — Posted on 2022-03-03
3892 Aging the Brain: Multi-Region Methylation Principal Component Based Clock in the Context of Alzheimer's Disease
Thrush, K. L.; Bennett, D. A.; Gaiteri, C.; Horvath, S.; van Dyck, C. H.; Higgins-Chen, A. T.; Levine, M. E.
10.1101/2022.02.28.481849 — bioinformatics — Posted on 2022-03-03
3894 The GEF-GAP pair Solo and DLC3 balances Rho activity during endocytic transport
Lungu, C.; Meyer, F.; Hörning, M.; Steudle, J.; Braun, A.; Noll, B.; Benz, D.; Frankle, F.; Schmid, S.; Eisler, S. A.; Olayioye, M. A.
10.1101/2022.03.01.482527 — cell biology — Posted on 2022-03-03
3896 PeakBot: Machine learning based chromatographic peak picking
Bueschl, C.; Doppler, M.; Varga, E.; Seidl, B.; Flasch, M.; Warth, B.; Zanghellini, J.
10.1101/2021.10.11.463887 — bioinformatics — Posted on 2022-03-03
3899 Cellular and Circuit Organization of the Locus Coeruleus of Adult Mice
Jiang, X.; Sheth, B. R.; McKinney, A.; Hu, M.; Jing, J.; Hoskins, A.; Mohammadyar, A.; Naeem, N.; Patel, S.
10.1101/2022.03.01.481656 — neuroscience — Posted on 2022-03-03
3903 What drives wolf preference towards wild ungulates? Insights from a multi-prey system in the Slovak Carpathians
Guimaraes, N. F.; Alvares, F.; Durova, J.; Urban, P.; Bucko, J.; Ilko, T.; Brndiar, J.; Stofik, J.; Pataky, T.; Barancekova, M.; Kropil, R.; Smolko, P.
10.1101/2022.03.02.482693 — zoology — Posted on 2022-03-02
3904 The brassinosteroid biosynthesis gene TaD11-2A controls grain size and its elite haplotype improves wheat grain yields
Xu, H.; Sun, H.; Dong, J.; Ma, C.; Li, J.; Li, Z.; Wang, Y.; Ji, J.; Hu, X.; Wu, M.; Zhao, C.; Qin, R.; Wu, J.; Ni, F.; Cui, F.; Wu, Y.
10.1101/2022.02.17.480859 — plant biology — Posted on 2022-03-02
3908 Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency
Munoz, M. A.; Skinner, O. P.; Masle-Farquhar, E.; Jurczyluk, J.; Xiao, Y.; Fletcher, E. K.; Kristianto, E.; Hodson, M. P.; O'Donoghue, S. I.; Kaur, S.; Brink, R.; Zahra, D.; Deenick, E. K.; Perry, K.; Robertson, A. A.; Mehr, S.; Hissaria, P.; Mulders-Manders, C. M.; Simon, A.; Rogers, M. J.
10.1101/2022.02.28.480959 — physiology — Posted on 2022-03-02
3909 Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci
Sudarshan, D.; Avvakumov, N.; Lalonde, M.-E.; Alerasool, N.; Joly-Beauparlant, C.; Jacquet, K.; Mameri, A.; Lambert, J.-P.; Rousseau, J.; Lachance, C.; Paquet, E.; Herrmann, L.; Setty, S. T.; Loehr, J.; Bernardini, M. Q.; Rouzbahman, M.; Gingras, A.-C.; Coulombe, B.; Droit, A.; Taipale, M.; Doyon, Y.; Cote, J.
10.1101/2021.03.26.436670 — molecular biology — Posted on 2022-03-02
3912 A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice
Maksimov, M.; Ashbrook, D. G.; BXD Sequencing Consortium, ; Villani, F.; Colonna, V.; Mousavi, N.; Ma, N.; Palmer, A. A.; Gymrek, M.
10.1101/2022.03.02.482700 — genomics — Posted on 2022-03-02
3917 A dissemination-prone morphotype enhances extrapulmonary organ entry by the fungus Cryptococcus neoformans
Denham, S. T.; Brammer, B.; Chung, K. Y.; Wambaugh, M. A.; Bednarek, J.; Guo, L.; Brown, J. C. S.
10.1101/2020.08.27.270843 — microbiology — Posted on 2022-03-02
3918 Dynamic Sex Differences in Reactive and Appetitive Aggression
Aubry, A.; Burnett, C. J.; Goodwin, N.; Li, L.; Navarrete, J.; Zhang, Y.; Tsai, V.; Durand-de Cuttoli, R.; Golden, S.; Russo, S.
10.1101/2022.02.22.481480 — neuroscience — Posted on 2022-03-02
3919 RT-DeCal: A hardware system for real-time decoding of in-vivo calcium imaging data
Chen, Z.; Blair, G. J.; Guo, C.; Zhou, J.; Izquierdo, A.; Golshani, P.; Cong, J.; Aharoni, D.; Blair, H. T.
10.1101/2022.01.31.478424 — neuroscience — Posted on 2022-03-02
3920 The conserved transcriptional program of metazoan male germ cells uncovers ancient origins of human infertility
Correia, R. B.; Almeida, J. M.; Wyrwoll, M. J.; Julca, I.; Sobral, D.; Misra, C. S.; Guilgur, L. G.; Schuppe, H.-C.; Silva, N.; Prudêncio, P.; Nóvoa, A.; Leocádio, A. S.; Bom, J.; Mallo, M.; Kliesch, S.; Mutwil, M.; Rocha, L. M.; Tüttelmann, F.; Becker, J. D.; Navarro-Costa, P.
10.1101/2022.03.02.482557 — systems biology — Posted on 2022-03-02
3922 Improving Martini 3 for disordered and multidomain proteins
Thomasen, F. E.; Pesce, F.; Roesgaard, M. A.; Tesei, G.; Lindorff-Larsen, K.
10.1101/2021.10.01.462803 — biophysics — Posted on 2022-03-02
3923 Using Biometric Data to Measure and Predict Emotional Engagement of Video Games
Vazquez, J.; Abdelrahman, S.; Wasden, C.; Jardine, S.; Judd, C.; Davis, M.; Facelli, J. C.
10.1101/2022.02.28.482337 — bioinformatics — Posted on 2022-03-02
3925 Cell-specific regulation of gene expression using splicing-dependent frameshifting.
Ling, J.; Bygrave, A.; Santiago, C.; Carmen, R.; Trinh, V.; Yu, M.; Li, Y.; Han, J.; Taneja, K.; Liu, Y.; Dongmo, R.; Babola, T.; Parker, P.; Jiang, L.; Leavey, P.; Smith, J.; Vistein, R.; Gimmen, M.; Dubner, B.; Teodorescu, P.; KARANTANOS, T.; Ghiaur, G.; Kanold, P.; Bergles, D. E.; Langmead, B.; Sun, S.; Nielsen, K.; Peachey, N.; Singh, M.; Dalton, W.; Rajaii, F.; Huganir, R. L.; Blackshaw, S.
10.1101/2022.03.02.481623 — molecular biology — Posted on 2022-03-02
3927 Feeding Growing Mushrooms
Sonnenberg, A.; Baars, J. J. P.; Straatsma, G.; Hendrickx, P.; Blok, C.; Hendrix, E.; F. van Peer, A.
10.1101/2022.03.01.482594 — microbiology — Posted on 2022-03-02
3928 Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period
Dawen, E.; Narowski, T. M.; Wang, E.; Garrigan, E.; Mateus, J.; Frazier, A.; Weiskopf, D.; Grifoni, A.; Premkumar, L.; Sette, A.; da Silva Antunes, R.
10.1101/2022.03.01.482548 — immunology — Posted on 2022-03-02
3929 Intranasal Immunization with a Proteosome-Adjuvanted SARS-CoV2 Spike Protein-Based Vaccine is Immunogenic and Efficacious in Mice & Hamsters
Stark, F. C.; Akache, B.; Deschatelets, L.; Tran, A.; Stuible, M.; Durocher, Y.; McCluskie, M. J.; Agbayani, G.; Dudani, R.; Harrison, B. A.; Renner, T. M.; Makinen, S. R.; Bavananthasivam, J.; Duque, D.; Zarley, C. D.; Cochrane, T. R.; Handfield, M.; Gagne, M.; Zimmermann, J.
10.1101/2022.03.02.482651 — immunology — Posted on 2022-03-02
3930 Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses
Weymar, G. H.; Bar-On, Y.; Oliveira, T. Y.; Gaebler, C.; Ramos, V.; Hartweger, H.; Breton, G.; Caskey, M.; Cohn, L. B.; Jankovic, M.; Nussenzweig, M. C.
10.1101/2022.03.02.482683 — immunology — Posted on 2022-03-02
3932 Single cell atlas of the neonatal small intestine with necrotizing enterocolitis
Egozi, A.; Olaloye, O.; Werner, L.; Silva, T.; McCourt, B.; Pierce, R.; An, X.; Wang, F.; Chen, K.; Pober, J.; Shouval, D.; Itzkovitz, S.; Konnikova, L.
10.1101/2022.03.01.482508 — immunology — Posted on 2022-03-02
3933 Kv7 channel antagonists block glycine receptors
Lu, H.-W.; Romero, G. E.; Apostolides, P. F.; Huang, H.; Trussell, L. O.
10.1101/2022.03.02.482705 — neuroscience — Posted on 2022-03-02
3935 C21orf2 mutations found in ALS disrupt primary cilia function
De Decker, M.; Zelina, P.; Moens, T. G.; Eggermont, K.; Moisse, M.; Veldink, J. H.; Van Den Bosch, L.; Pasterkamp, R. J.; Van Damme, P.
10.1101/2022.02.28.482239 — neuroscience — Posted on 2022-03-02
3938 Development of a dedicated Golden Gate Assembly platform (RtGGA) for Rhodotorula toruloides
Bonturi, N.; Pinheiro, M. J.; Monteiro de Oliveira, P.; Rusadze, E.; Eichinger, T.; Liudziute, G.; Sabedotti De Biaggi, J.; Brauer, A.; Remm, M.; Miranda, E. A.; Ledesma-Amaro, R.; Lahtvee, P.-J.
10.1101/2022.03.02.482697 — synthetic biology — Posted on 2022-03-02
3940 A Standardized Framework for Taxonomy Analysis in Bacterial Kingdom based on Protein Domain
Wang, B.; Zhou, J.; Jin, Y.; Hu, M.; Zhao, Y.; Wang, X.; Liang, L.; Yue, J.; Ren, H.
10.1101/2022.02.28.482430 — bioinformatics — Posted on 2022-03-02
3941 ECD of PepT1 interacts with TM1 to facilitate substrate transport
Shen, J.; Hu, M.; Ren, Z.; Fan, X.; Portioli, C.; Yan, X.; Rong, M.; Zhou, M.
10.1101/2022.03.01.482558 — biochemistry — Posted on 2022-03-02
3942 Genome-Wide DNA Methylation Profiling of the Failing Human Heart with Mechanical Unloading Identifies LINC00881 as an Essential Regulator of Calcium Handling in the Cardiomyocyte
Liao, X.; Kennel, P.; Liu, B.; Nash, T.; Zuang, R.; Godier-Furnemont, A.; Xue, C.; Lu, R.; Colombo, P.; Uriel, N.; Reilly, M.; Marx, S.; Vunjak-Novakovic, G.; Topkara, V. K.
10.1101/2022.03.01.482163 — genomics — Posted on 2022-03-02
3943 Double knockout CRISPR screen in cancer resistance to T cell cytotoxicity
Park, J.; Codina, A.; Ye, L.; Lam, S.; Guo, J.; Clark, P.; Zhou, X.; Peng, L.; Chen, S.
10.1101/2022.03.01.482556 — genomics — Posted on 2022-03-02
3948 The 3D structure of lipidic fibrils of α-synuclein
Frieg, B.; Antonschmidt, L.; Dienemann, C.; Geraets, J. A.; Najbauer, E. E.; Matthes, D.; de Groot, B. L.; Andreas, L. B.; Becker, S.; Griesinger, C.; Schroder, G. F.
10.1101/2022.03.02.481946 — molecular biology — Posted on 2022-03-02
3951 Combining transgenesis with paratransgenesis to fight malaria
Huang, W.; Vega-Rodriguez, J.; Kizito, C.; Cha, S.-J.; Jacobs-Lorena, M.
10.1101/2022.03.02.482642 — microbiology — Posted on 2022-03-02
3953 Longitudinal analysis of the gut microbiome in the 5xfAD mouse model of Alzheimer's disease
Dunham, S. J. B.; McNair, K. A.; Adams, E. D.; Avelar-Barragan, J.; Forner, S.; Mapstone, M.; Whiteson, K.
10.1101/2022.03.02.482725 — microbiology — Posted on 2022-03-02
3954 Functional characterization of the thrombospondin-related paralogous proteins rhoptry discharge factor 1 and 2 unveils phenotypic plasticity in Toxoplasma gondii rhoptry exocytosis
Possenti, A.; Di Cristina, M.; Nicastro, C.; Lunghi, M.; Messina, V.; Piro, F.; Tramontana, L.; Cherchi, S.; Falchi, M.; Bertuccini, L.; Spano, F.
10.1101/2022.03.02.482699 — microbiology — Posted on 2022-03-02
3955 Rapid hypermutation B cell trajectory recruits previously primed B cells upon third SARS-CoV-2 mRNA vaccination
Paschold, L.; Klee, B.; Gottschick, C.; Willscher, E.; Diexer, S.; Schultheiss, C.; Simnica, D.; Sedding, D.; Girndt, M.; Gekle, M.; Mikolajczyk, R.; Binder, M.
10.1101/2022.03.01.482462 — immunology — Posted on 2022-03-02
3956 Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma
Grace, B. E.; Backlund, C. M.; Morgan, D. M.; Kang, B. H.; Singh, N. K.; Huisman, B. D.; Rappazzo, C. G.; Moynihan, K. D.; Maiorino, L.; Dobson, C. S.; Kyung, T.; Gordon, K. S.; Holec, P. V.; Mbah, O. C. T.; Garafola, D.; Wu, S.; Love, J. C.; Wittrup, K. D.; Irvine, D. J.; Birnbaum, M. E.
10.1101/2022.02.28.482028 — immunology — Posted on 2022-03-02
3958 Reconstruction and simulation of thalamoreticular microcircuitry
Iavarone, E.; Simko, J.; Shi, Y.; Bertschy, M.; Amado, M. G.; Litvak, P.; Kaufmann, A.-K.; O'Reilly, C.; Amsalem, O.; Abdellah, M.; Chevtchenko, G.; Coste, B.; Courcol, J.-D.; Ecker, A.; Favreau, C.; Fleury, A. C.; Van Geit, W.; Gevaert, M.; Guerrero, N. R.; Herttuainen, J.; Ivaska, G.; Kerrien, S.; King, J. G.; Kumbhar, P.; Lurie, P.; Magkanaris, I.; Muddapu, V. R.; Nair, J.; Pereira, F. L.; Perin, R.; Petitjean, F.; Ranjan, R.; Reimann, M.; Soltuzu, L.; Sy, M. F.; Ulbrich, A.; Tuncel, M. A.; Wolf, M.; Clasca, F.; Markram, H.; Hill, S. L.
10.1101/2022.02.28.482273 — neuroscience — Posted on 2022-03-02
3959 Neuronal-spiking-based closed-loop stimulationduring cortical ON and OFF states in freely moving mice
Kahn, M. C.; Krone, L. B.; Blanco-Duque, C.; Guillaumin, M. C. C.; Mann, E. O.; Vyazovskiy, V. V.
10.1101/2022.02.28.482319 — neuroscience — Posted on 2022-03-02
3960 Localizing temporal lobe seizure onset zones using deep learning on SEEG cortico-cortical evoked potentials
Johnson, G. W.; Cai, L. Y.; Doss, D. J.; Jiang, J. W.; Negi, A. S.; Narasimhan, S.; Paulo, D. L.; Gonzalez, H. F.; Roberson, S. W.; Bick, S. K.; Chang, C. E.; Morgan, V. L.; Wallace, M. T.; Englot, D. J.
10.1101/2022.02.28.481828 — neuroscience — Posted on 2022-03-02
3962 Fly-casting with ligand-sliding and orientational selection to support the complex formation of a GPCR and a middle-sized flexible molecule
Higo, J.; Kasahara, K.; Bekker, G.-J.; Ma, B.; Sakuraba, S.; Iida, S.; Kamiya, N.; Fukuda, I.; Kono, H.; Fukunishi, Y.; Nakamura, H.
10.1101/2022.02.28.482421 — biophysics — Posted on 2022-03-02
3964 Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease
Frazier, M. N.; Wilson, I. M.; Krahn, J. M.; Butay, K. J.; Dillard, L. B.; Borgnia, M. J. N.; Stanley, R. E.
10.1101/2022.03.02.480688 — biochemistry — Posted on 2022-03-02
3965 Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening
Roy, A.; Alhammad, Y. M.; McDonald, P.; Johnson, D. K.; Zhuo, J.; Wazir, S.; Ferraris, D. V.; Lehtiö, L.; Leung, A.; Fehr, A. R.
10.1101/2022.03.01.482536 — biochemistry — Posted on 2022-03-02
3967 Genetic Variation and Disease Severity of Respiratory Syncytial Viruses
Anderson, C. S.; Zhang, Y.; Corbett, A.; Chu, C.; Grier, A.; Wang, L.; Qiu, X.; Mccall, M.; Topham, D. J.; Walsh, E.; Mariani, T. J.; Scheuermann, R. H.; Caserta, M.
10.1101/2022.02.28.482432 — microbiology — Posted on 2022-03-02
3969 Turning the head while biking makes older people lose cycling direction and balance
Afschrift, M.; Matthijs, A.; De Ryck, T.; De Groote, F.; Orban De Xivry, J.-J.
10.1101/2022.03.01.481993 — neuroscience — Posted on 2022-03-02
3972 In vivo physiology of foveal retinal ganglion cells in Macaca fascicularis
Godat, T.; Cottaris, N. P.; Patterson, S.; Kohout, K.; Parkins, K.; Yang, Q.; Strazzeri, J. M.; McGregor, J. E.; Brainard, D. H.; Merigan, W. H.; Williams, D. R.
10.1101/2022.02.28.482294 — neuroscience — Posted on 2022-03-02
3973 Visual Perception of 3D Space and Shape in Time - Part II: 3D Space Perception with Holographic Depth
Bustanoby, I. F.; Krupien, A.; Afifa, U.; Asdell, B.; Bacani, M.; Boudreau, J.; Carmona, J.; Chandrashekar, P.; Diamond, M.; Espino, D.; Gangal, A.; Kittur, C.; Li, Y.; Mann, T.; Matamoros, C.; McCarthy, T.; Mills, E.; Nazareth, S.; Nguyen, J.; Ochoa, K.; Robbins, S.; Sparakis, D.; Ta, B.; Trengove, K.; Xu, T.; Yamaguchi, N.; Yang, C.; Zafran, E.; Blaisdell, A. P.; Arisaka, K.
10.1101/2022.02.28.482181 — neuroscience — Posted on 2022-03-02
3976 Case Study of Single-cell Protein Activity Based Drug Prediction for Precision Treatment of Cholangiocarcinoma
Obradovic, A.; Tomassoni, L.; Yu, D.; Guillan, K.; Souto, K.; Fraser, E.; Bates, S.; Drake, C. G.; Saenger, Y.; Cruz, F. D.; Kung, A.; Califano, A.
10.1101/2022.02.28.482410 — cancer biology — Posted on 2022-03-02
3977 Triple Negative Breast Cancer-derived Small Extracellular Vesicles as Modulator of Biomechanics in target cells
Senigagliesi, B.; Samperi, G.; Cefarin, N.; Gneo, L.; Petrosino, S.; Apollonio, M.; Caponnetto, F.; Sgarra, R.; Collavin, L.; Cesselli, D.; Casalis, L.; Parisse, P.
10.1101/2022.02.28.481921 — biophysics — Posted on 2022-03-02
3985 Diversity of sex chromosomes in Sulawesian medaka fishes
Ansai, S.; Montenegro, J.; Masengi, K. W. A.; Nagano, A. J.; Yamahira, K.; Kitano, J.
10.1101/2022.02.28.482394 — evolutionary biology — Posted on 2022-03-02
3987 Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows
Jeong, H.; Baran, N. M.; Sun, D.; Chatterjee, P.; Layman, T. S.; Balakrishnan, C. M.; Maney, D. L.; Yi, S. V.
10.1101/2022.02.28.481145 — evolutionary biology — Posted on 2022-03-02
3989 Arctic evergreening - encroaching allelopathy in a management blind spot
Tuomi, M. W.; Utsi, T. A.; Yoccoz, N.; Armstrong, C. W.; Gonzalez, V.; Hagen, S. B.; Jonsdottir, I. S.; Pham, M. N.; Pugnaire, F. I.; Shea, K.; Wardle, D. A.; Zielosko, S.; Brathen, K. A.
10.1101/2022.02.28.482210 — ecology — Posted on 2022-03-02
3991 Keratinocyte-tethering modification for biologics enables location-precise treatment in mouse vitiligo
Hsueh, Y.-C.; Wang, Y.; Riding, R. L.; Catalano, D. E.; Lu, Y.-J.; Richmond, J. M.; Siegel, D. L.; Rusckowski, M.; Stanley, J. R.; Harris, J. E.
10.1101/2022.02.28.482387 — immunology — Posted on 2022-03-02
3993 Psilocybin induces spatially constrained alterations in thalamic functional organization and connectivity
Gaddis, A.; Lidstone, D. E.; Nebel, M. B.; Griffiths, R. R.; Mostofsky, S. H.; Meija, A.; Barrett, F. S.
10.1101/2022.02.28.482395 — neuroscience — Posted on 2022-03-02
3995 A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity
Gera, S.; Kuo, T.-C.; Korkmaz, F.; Sant, D.; DeMambro, V.; Gumerova, A. A.; Sudha, K.; Padilla, A.; Prevot, G.; Munitz, J.; Teunissen, A.; van Leent, M. M. T.; Post, T. G. J. M.; Fernandes, J. C.; Netto, J.; Sultana, F.; Shelly, E.; Kumar, P.; Cullen, L.; Chatterjee, J.; Miyashita, S.; Kannangara, H.; Bhongade, M.; Ievleva, K.; Muradova, V.; Batista, R.; Robinson, C.; Macdonald, A.; Babunovic, S.; Saxena, M.; Meseck, M.; Caminis, J.; Iqbal, J.; New, M. I.; Ryu, V.; Kim, S.-M.; Cao, J.; Zaidi, N.; Fayad, Z. A.; Lizneva, D.; J. Rosen, C.; Yuen, T.; Zaidi, M.
10.1101/2022.02.28.482279 — pharmacology and toxicology — Posted on 2022-03-02
3996 Cytologic Scoring of Equine Exercise-Induced Pulmonary Hemorrhage (EIPH): Performance of Human Experts and a Deep Learning-Based Algorithm
Bertram, C. A.; Marzahl, C.; Bartel, A.; Stayt, J.; Bonsembiante, F.; Beeler-Marfisi, J.; Barton, A. K.; Brocca, G.; Gelain, M. E.; Glaesel, A.; du Preez, K.; Weiler, K.; Weissenbacher-Lang, C.; Breininger, K.; Aubreville, M.; Maier, A.; Klopfleisch, R.; Hill, J.
10.1101/2022.02.28.482322 — pathology — Posted on 2022-03-02
3997 P4HA2: A link between tumor-intrinsic hypoxia, partial EMT and collective migration
Aggarwal, V.; Sahoo, S.; Donnenberg, V. S.; Chakraborty, P.; Jolly, M. K.; Sant, S.
10.1101/2022.02.28.482409 — cancer biology — Posted on 2022-03-02
4000 A microfluidics-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer
Carvalho, A.; Guimaraes-Teixeira, C.; Constancio, V.; Fernandes, M.; Macedo-Silva, C.; Henrique, R.; Monteiro, F. J.; Jeronimo, C.
10.1101/2022.02.28.482380 — bioengineering — Posted on 2022-03-02
4001 Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain
Dewangan, P. S.; Beraki, T.; Paiz, E. A.; Mensah, D. A.; Chen, Z.; Reese, M. L.
10.1101/2022.03.02.482640 — biochemistry — Posted on 2022-03-02
4003 Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction
Hindley, G.; Shadrin, A. A.; van der Meer, D.; Parker, N.; Cheng, W.; O'Connell, K. S.; Bahrami, S.; Lin, A.; Karadag, N.; Holen, B.; Bjella, T.; Fan, C. C.; Uelan, T.; Djurovic, S.; Smeland, O. B.; Frei, O.; Dale, A.; Andreassen, O.
10.1101/2022.02.28.481967 — genetics — Posted on 2022-03-02
4005 Genomic patterns of divergence in the early and late steps of speciation of the deep-sea vent thermophilic worms of the genus Alvinella.
Thomas-Bulle, C.; Bertrand, D.; Nagarajan, N.; Copley, R.; Corre, E.; Hourdez, S.; Bonnivard, E.; Claridge-Chang, A.; Jollivet, D.
10.1101/2022.02.28.482349 — evolutionary biology — Posted on 2022-03-02
4006 Genomic resolution of cryptic species diversity in chipmunks
Herrera, N. D.; Bell, K. C.; Callahan, C. M.; Nordquist, E.; Sarver, B. A. J.; Sullivan, J.; Demboski, J. R.; Good, J. M.
10.1101/2022.02.28.482304 — evolutionary biology — Posted on 2022-03-02
4007 Transcriptome and DNA methylome dynamics reveal differential characteristics of inflorescence development between two ecotypes in Panicum hallii
Weng, X.; Song, H.; Sreedasyam, A.; Haque, T.; Zhang, L.; Chen, C.; Yoshinaga, Y.; Williams, M.; O'Malley, R. C.; Grimwood, J.; Schmutz, J.; Juenger, T. E.
10.1101/2022.02.28.482119 — evolutionary biology — Posted on 2022-03-02
4013 Selective endocytosis controls slit diaphragm maintenance and dynamics.
Lang, K.; Milosavljevic, J.; Heinkele, H.; Chen, M.; Gerstner, L.; Spitz, D.; Kayser, S.; Helmstaedter, M.; Walz, G.; Koettgen, M.; Spracklen, A. J.; Poulton, J. S.; Hermle, T.
10.1101/2022.03.01.482547 — cell biology — Posted on 2022-03-02
4014 Heterogeneity of Inflammation-associated Synovial Fibroblasts in Rheumatoid Arthritis and Its Drivers
Smith, M. H.; Gao, V. R.; Schizas, M.; Kochen, A.; DiCarlo, E.; Goodman, S.; Norman, T. M.; Donlin, L.; Leslie, C. S.; Rudensky, A. Y.
10.1101/2022.02.28.482131 — immunology — Posted on 2022-03-02
4016 Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
Yshii, L.; Pasciuto, E.; Bielefeld, P.; Mascali, L.; Lemaitre, P.; Marino, M.; Dooley, J.; Kouser, L.; Verschoren, S.; Lagou, V.; Kemps, H.; Gervois, P.; de Boer, A.; Burton, O.; Wahis, J.; Tareen, S.; Roca, C.; Singh, K.; Whyte, C.; Kerstens, A.; Callaerts-Vegh, Z.; Poovathingal, S.; Prezzemolo, T.; Wierda, K.; Dashwood, A.; Xie, J.; Van Wonterghem, E.; Creemers, E.; Aloulou, M.; Gsell, W.; Abiega, O.; Munck, S.; Vandenbroucke, R.; Lemmens, R.; De Strooper, B.; Van Den Bosch, L.; Himmelreich, U.; Fitzsimons, C. P.; Holt, M.; Liston, A.
10.1101/2022.02.28.482297 — immunology — Posted on 2022-03-02
4017 Stage dependent differential influence of metabolic and structural networks on memory across Alzheimer's disease continuum
Zhou, J. H.; Alzheimer's Disease Neuroimaging Initiative, ; Ng, K. P.; Qian, X.; Ng, K. K.; Ji, F.; Rosa-Neto, P.; Gauthier, S.; Kandiah, N.
10.1101/2022.02.28.482280 — neuroscience — Posted on 2022-03-02
4018 Brain signal predictions from multi-scale networks using a linearized framework
Hagen, E.; Magnusson, S. H.; Ness, T. V.; Halnes, G.; Babu, P. N.; Linssen, C.; Morrison, A.; Einevoll, G. T.
10.1101/2022.02.28.482256 — neuroscience — Posted on 2022-03-02
4019 Rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought
Venkataraman, K.; Shai, N.; Lakhiani, P.; Zylka, S.; Zhao, J.; Herre, M.; Zeng, J.; Neal, L. A.; Molina, H.; Zhao, L.; Vosshall, L. B.
10.1101/2022.03.01.482582 — neuroscience — Posted on 2022-03-02
4020 Social deficits induced by pervasive environmental stressors are prevented by microbial or dopaminergic modulation
Smith, C. J.; Rendina, D. N.; Kingsbury, M. A.; Malacon, K. E.; Nguyen, D. M.; Tran, J. J.; Devlin, B. A.; Clark, M. J.; Raju, R. M.; Burgett, L.; Zhang, J. H.; Cetinbas, M.; Sadreyev, R. I.; Chen, K.; Iyer, M. S.; Bilbo, S. D.
10.1101/2022.02.28.482288 — neuroscience — Posted on 2022-03-02
4021 Temporal responses of bumblebee gustatory neurons encode sugar identity
Parkinson, R.; Kessler, S.; Scott, J.; Simpson, A.; Bu, J.; Pattrick, J.; Mahdi, A.; Miriyala, A.; Wright, G.
10.1101/2022.02.28.482341 — neuroscience — Posted on 2022-03-02
4024 Regulation strategies for two-output biomolecular networks
Alexis, E.; Schulte, C. C. M.; Cardelli, L.; Papachristodoulou, A.
10.1101/2022.02.28.482258 — synthetic biology — Posted on 2022-03-02
4026 Identification of potential inhibitors of cutaneous Melanoma and Non-Melanoma skin cancer cells through in vitro and in silico screening of a small library of Phenolic compounds
Boateng, S. T.; Roy, T.; Agbo, M. E.; Banang-Mbeumi, S.; Chamcheu, R.-C. N.; Bramwell, M.; Pham, L. K.; Jackson, K. E.; Hill, R. A.; Nagalo, B. M.; Efimova, T.; Fotie, J.; Chamcheu, J. C.
10.1101/2022.02.28.482167 — pharmacology and toxicology — Posted on 2022-03-02
4027 Cholesterol in the cargo membrane reduces kinesin-1 binding to microtubules in the presence of tau
Li, Q.; Ferrare, J. T.; Silver, J.; Wilson, J. O.; Arteaga-Castaneda, L.; Qiu, W.; Vershinin, M.; King, S. J.; Neuman, K. C.; Xu, J.
10.1101/2022.03.01.482581 — biophysics — Posted on 2022-03-02
4028 Using Biometric Data to Measure and Predict Emotional Engagement of Video Games
Vazquez, J.; Abdelrahman, S.; Wasden, C.; Jardine, S.; Judd, C.; Davis, M.; Facelli, J. C.
10.1101/2022.02.28.482337 — bioinformatics — Posted on 2022-03-02
4029 A Duplex Structure of SARM1 Octamers Induced by a New Inhibitor
Khazma, T.; Golan-Vaishenker, Y.; Guez-Haddad, J.; Grossman, A.; Sain, R.; Plotnikov, A.; Zalk, R.; Yaron, A.; Hons, M.; Opatowsky, Y.
10.1101/2022.03.02.482641 — biochemistry — Posted on 2022-03-02
4030 Ligand-mediated structural dynamics of a mammalian pancreatic KATP channel
Sung, M. W.; Driggers, C. M.; Mostofian, B.; Russo, J. D.; Patton, B. L.; Zuckerman, D. M.; Shyng, S.-L.
10.1101/2022.03.02.482692 — biochemistry — Posted on 2022-03-02
4031 Cyclin CLB2 mRNA localization determines efficient protein synthesis to orchestrate bud growth and cell cycle progression
Tutucci, E.; Maekiniemi, A.; Snoep, J. L.; Seiler, M.; van Rossum, K.; van Niekerk, D. D.; Savakis, P.; Zarnack, K.; Singer, R. H.
10.1101/2022.03.01.481833 — cell biology — Posted on 2022-03-02
4032 LITOS - a versatile LED illumination tool for optogenetic stimulation
Hoehener, T. C.; Landolt, A.; Dessauges, C.; Gagliardi, P. A.; Pertz, O.
10.1101/2022.03.02.482623 — cell biology — Posted on 2022-03-02
4033 Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.
Wells, C. D.; Lange, K.; Thompson, A. F.; Xu, W. M.; Clendenon, S. G.; Underwood, J. S.; Harris, P.; Herbert, B.-S.; Glazier, J. A.; Wandinger-Ness, A.; Bacallao, R. L.
10.1101/2022.03.01.482118 — cell biology — Posted on 2022-03-02
4034 TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
Zhou, J.; Rasmussen, N. L.; Olsvik, H. L.; Akimov, V.; Hu, Z.; Evjen, G.; Blagoev, B.; Lamark, T.; Johansen, T.; Dengjel, J.
10.1101/2022.03.02.482646 — cell biology — Posted on 2022-03-02
4035 Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets
Yamamoto, K.; Scavenius, C.; Meschis, M. M.; Mogensen, E. H.; Gremida, A. M. E.; Thogersen, I. B.; Bonelli, S.; Scilabra, S. D.; Santamaria, S.; Ahnström, J.; Bou-Gharios, G.; Enghild, J. J.; Nagase, H.
10.1101/2022.03.02.482546 — cell biology — Posted on 2022-03-02
4037 Capturing the interplay of membrane lipids and structural transitions in human ABCA7
Le, L. T. M.; Thompson, J. R.; Dehghanighahnaviyeh, S.; Pant, S.; Dang, P. X.; Kanekiyo, T.; Tajkhorshid, E.; Alam, A.
10.1101/2021.03.01.433448 — biophysics — Posted on 2022-03-02
4040 Major transcriptomic, epigenetic and metabolic changes underly the pluripotency continuum in rabbit preimplantation embryos
Bouchereau, W.; Jouneau, L.; Archilla, C.; Aksoy, I.; Moulin, A.; Daniel, N.; Peynot, N.; Calderari, S.; Joly, T.; Godet, M.; Jaszczyszyn, Y.; Pratlong, M.; Severac, D.; Savatier, P.; Duranthon, V.; Afanassieff, M.; Beaujean, N.
10.1101/2021.10.06.463389 — developmental biology — Posted on 2022-03-02
4041 Mechanosensitive control of mitotic entry
Dantas, M.; Oliveira, A.; Aguiar, P.; Maiato, H.; Ferreira, J. G.
10.1101/2021.09.23.461473 — cell biology — Posted on 2022-03-02
4042 Deciphering the potential niche of two novel black yeast fungi from a biological soil crust based on their genomes, phenotypes, and melanin regulation
Carr, E. C.; Barton, Q.; Grambo, S.; Renfro, C.; Sullivan, M. T.; Kuo, A.; Pangilinan, J.; Lipzen, A.; Keymanesh, K.; Savage, E.; Barry, K.; Grigoriev, I. V.; Riekhof, W. R.; Harris, S. D.
10.1101/2021.12.03.471027 — microbiology — Posted on 2022-03-02
4045 Neonatal multi-modal cortical profiles predict 18-month developmental outcomes
Fenchel, D.; Dimitrova, R.; Robinson, E. C.; Batalle, D.; Chew, A.; Falconer, S.; Kyriakopoulou, V.; Nosarti, C.; Hutter, J.; Christiaens, D.; Pietsch, M.; Brandon, J.; Hughes, E. J.; Allsop, J.; O'Keeffe, C.; Price, A. N.; Cordero-Grande, L.; Schuh, A.; Makropoulos, A.; Passerat-Palmbach, J.; Bozek, J.; Rueckert, D.; Hajnal, J. V.; McAlonan, G.; Edwards, A. D.; O'Muircheartaigh, J.
10.1101/2021.09.23.461464 — neuroscience — Posted on 2022-03-02
4046 Ketamine and sleep modulate neural complexity dynamics in cats
Pascovich, C.; Castro-Zaballa, S.; Mediano, P. A. M.; Bor, D.; Canales-Johnson, A.; Torterolo, P. D.; Bekinschtein, T. A.
10.1101/2021.06.25.449513 — neuroscience — Posted on 2022-03-02
4047 Social cues of safety can override differences in threat level
Ferreira, C. H.; Heinemans, M.; Farias, M.; Goncalves, R.; Moita, M.
10.1101/2022.02.27.481960 — neuroscience — Posted on 2022-03-02
4050 Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting
Cao, R.; Zhai, L.; Xie, Q.; Wang, Z.; Zheng, Y.; Zhang, W.; Buell, A. K.; Xu, X.; Dong, Y.; Xu, C.; Lyu, W.
10.1101/2022.02.27.482192 — biochemistry — Posted on 2022-03-02
4054 Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.
Venzon, M.; Bernard-Raichon, L.; Klein, J.; Axelrad, J. E.; Zhang, C.; Hussey, G. A.; Sullivan, A. P.; Cassanovas-Massana, A.; Noval, M. G.; Valero-Jimenez, A. M.; Gago, J.; Putzel, G.; Pironti, A.; Wilder, E.; Yale IMPACT Research Team, ; Thorpe, L. E.; Littman, D. R.; Dittmann, M.; Stapleford, K. A.; Shopsin, B.; Torres, V. J.; Ko, A. I.; Iwasaki, A.; Cadwell, K.; Schluter, J.
10.1101/2021.07.15.452246 — microbiology — Posted on 2022-03-02
4055 Modeling of individual neurophysiological brain connectivity
Kulik, S. D.; Douw, L.; van Dellen, E.; Steenwijk, M. D.; Geurts, J. J.; Stam, K. J.; Hillebrand, A.; Schoonheim, M. M.; Tewarie, P.
10.1101/2022.03.02.482608 — neuroscience — Posted on 2022-03-02
4056 Brain embeddings with shared geometry to artificial contextual embeddings, as a code for representing language in the human brain
Goldstein, A.; Dabush, A.; Aubrey, B.; Schain, M.; Nastase, S. A.; Zada, Z.; Ham, E.; Hong, Z.; Feder, A.; Gazula, H.; Buchnik, E.; Doyle, W.; Devore, S.; Dugan, P.; Friedman, D.; Brenner, M. P.; Hassidim, A.; Devinsky, O.; Flinker, A.; Hasson, U.
10.1101/2022.03.01.482586 — neuroscience — Posted on 2022-03-02
4058 HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification
Sapp, N. E.; Burge, N.; Cox, K.; Thapa, S.; Prakash, P.; Balasubramaniam, M.; Christensen, D.; Li, M.; Linderberger, J.; Kvaratskhelia, M.; Sundquist, W. I.; Pandhare, J.; Craigie, R.; Poirier, M. G.; Dash, C.
10.1101/2022.02.16.480507 — biochemistry — Posted on 2022-03-02
4060 The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
Raja, E.; Changarathil, G.; Oinam, L.; Ngo, Y. X.; Tsunezumi, J.; Ishii, R.; Sasaki, T.; Imanaka-Yoshida, K.; Yanagisawa, H.; Sada, A.
10.1101/2022.02.28.482241 — developmental biology — Posted on 2022-03-02
4067 4D Cell-Condensate Bioprinting
Ding, A.; Tang, R.; He, F.; Lee, S. J.; Gasvoda, K.; Alsberg, E.
10.1101/2022.02.28.482216 — bioengineering — Posted on 2022-03-02
4068 Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair
Kim, M.; Kim, H. S.; D'Souza, A.; Gallagher, K.; Jung, E.; Topolska-Wos, A.; Ogorodnik Le Meur, K.; Tsai, C.-L.; Tsai, M.-S.; Kee, M.; Tainer, J. A.; Yeo, J.-E.; Chazin, W. J.; Scharer, O. D.
10.1101/2022.03.01.482439 — biochemistry — Posted on 2022-03-02
4069 The role of floral traits in community assembly process at high elevations in Lesser Himalaya
Ahmad, M.; Rosbakh, S.; Bucher, S. F.; Sharma, P.; Rathee, S.; Uniyal, S. K.; Batish, D. R.; Singh, H. P.
10.1101/2022.02.26.482103 — ecology — Posted on 2022-03-02
4070 Temporal and environmental factors interact with rootstock genotype to shape leaf elemental composition in grafted grapevines
Harris, Z. N.; Pratt, J. E.; Bhakta, N.; Frawley, E.; Klein, L. L.; Kwasniewski, M.; Migicovsky, Z.; Miller, A.
10.1101/2022.02.28.482393 — plant biology — Posted on 2022-03-02
4071 A small-molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II
Liu, Y.; Iqbal, A.; Li, W.; Ni, Z.; Zhao, D. Y.; Abraham, K. J.; Tempel, W.; Guo, X.; Zhou, M.; Brown, P. J.; Qin, S.; Mekhail, K.; Greenblatt, J. F.; Min, J.
10.1101/829689 — biochemistry — Posted on 2022-03-02
4072 Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers
Gaugler, P.; Schneider, R.; Liu, G.; Qiu, D.; Weber, J.; Schmid, J.; Jork, N.; Häner, M.; Ritter, K.; Fernandez Rebollo, N.; Giehl, R. F. H.; Trung, M. N.; Yadav, R.; Fiedler, D.; Gaugler, V.; Jessen, H. J.; Schaaf, G.; Laha, D.
10.1101/2022.03.01.482514 — plant biology — Posted on 2022-03-02
4073 Genetic immune escape landscape in primary and metastatic cancer
Martinez-Jimenez, F.; Priestley, P.; Shale, C.; Baber, J.; Rozemuller, E.; Cuppen, E.
10.1101/2022.02.23.481444 — genomics — Posted on 2022-03-02
4076 Increased gut microbial mucin foraging promotes clearance of a parasitic worm
Wolter, M.; Grant, E. T.; Parrish, A.; De Sciscio, A.; Thompson, S.; Boudaud, M.; Gerardy, J.-J.; Mittelbronn, M.; Thornton, D. J.; Macpherson, A. J.; Grencis, R. K.; Desai, M. S.
10.1101/2022.02.28.482289 — immunology — Posted on 2022-03-02
4079 Advanced Functional Biotextiles for a Circular Materials Economy
Schiros, T. N.; Antrobus, R.; Farias, D.; Chiu, Y.-T.; Joseph, C. T.; Esdaille, S.; Sanchiricco, G. K.; Miquelon, G.; An, D.; Russell, S. T.; Chitu, A.; Goetz, S.; Chasse, A. M. V.; Nuckolls, C.; Kumar, S. K.; Lu, H. H.
10.1101/2021.09.22.461422 — bioengineering — Posted on 2022-03-02
4082 The RNA Virome of Echinoderms
Jackson, E. W.; Wilhelm, R. C.; Buckley, D. H.; Hewson, I.
10.1101/2022.03.01.482561 — microbiology — Posted on 2022-03-02
4083 Arbuscular mycorrhizal fungal composition across US citrus orchards, management strategies, and disease severity spectrum
Xi, M.; Deyett, E.; Ginnan, N.; Ashworth, V. E. T. M.; Dang, T.; Bodaghi, S.; Vidalakis, G.; Roper, M. C.; Glassman, S.; Rolshausen, P.
10.1101/2022.03.01.482593 — microbiology — Posted on 2022-03-02
4085 Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution
Kiefl, E.; Esen, O. C.; Miller, S. E.; Kroll, K. L.; Willis, A. D.; Rappe, M. S.; Pan, T.; Eren, A. M.
10.1101/2022.03.02.482602 — microbiology — Posted on 2022-03-02
4086 Age-Related Differences in Ventral Striatal and Default Mode Network Function During Reciprocated Trust
Fareri, D. S.; Hackett, K.; Tepfer, L. J.; Kelly, V. A.; Henninger, N.; Reeck, C.; Giovannetti, T.; Smith, D. V.
10.1101/2021.07.29.454071 — neuroscience — Posted on 2022-03-02
4090 Structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin at 1.97 A resolution
Li, J.; Hamaoka, N.; Makino, F.; Kawamoto, A.; Lin, Y.; Rögner, M.; Nowaczyk, M. M.; Lee, Y.-H.; Namba, K.; Gerle, C.; Kurisu, G.
10.1101/2022.03.01.482405 — plant biology — Posted on 2022-03-02
4092 Light activation of Orange Carotenoid Protein reveals initial C8'-C7' double bond trans/cis isomerization
Chukhutsina, V.; Baxter, J.; Fadini, A.; Morgan, R. M.; Pope, M.; Maghlaoui, K.; Orr, C.; Wagner, A.; van Thor, J.
10.1101/2022.01.17.475858 — biophysics — Posted on 2022-03-02
4093 Fine-mapping and identification of candidate causal genes for tail length in the Merinolandschaf breed
Lagler, D. K.; Hannemann, E.; Eck, K.; Klawatsch, J.; Seichter, D.; Russ, I.; Mendel, C.; Lühken, G.; Krebs, S.; Blum, H.; Upadhyay, M.; Međugorac, I.
10.1101/2022.02.27.481613 — genomics — Posted on 2022-03-02
4095 Using ultraconserved elements to reconstruct the termite tree of life
Hellemans, S.; Wang, M.; Hasegawa, N.; Sobotnik, J.; Scheffrahn, R. H.; Bourguignon, T.
10.1101/2021.12.09.472027 — evolutionary biology — Posted on 2022-03-02
4096 In Silico Evaluation of Plant Nitrification Suppression Effects on Agroecosystem Nitrogen Loss
Hartman, M. D.; Burnham, M. B.; Parton, W. J.; Finzi, A. C.; DeLucia, E. H.; Yang, W. H.
10.1101/2022.02.28.482267 — ecology — Posted on 2022-03-02
4105 A cooperative switch within the KaiC hexamer revealed by cryo-EM
Han, X.; Zhang, D.; Hong, L.; Yu, D.; Wu, Z.; Yang, T.; Rust, M.; Tu, Y.; Ouyang, Q.
10.1101/2022.02.27.481910 — biophysics — Posted on 2022-03-02
4106 What are the reference strains of Acinetobacter baumannii referring to?
Philippe, C.; Valcek, A.; Whiteway, C.; Robino, E.; Nesporova, K.; Bove, M.; Coenye, T.; De Pooter, T.; De Coster, W.; Strazisar, M.; Kenyon, J. J.; Van der Henst, C.
10.1101/2022.02.27.482139 — microbiology — Posted on 2022-03-02
4108 Widening the landscape of transcriptional regulation of algal photoprotection
Arend, M.; Yuan, Y.; Ruiz-Sola, M. A.; Omranian, N.; Nikoloski, Z.; Petroutsos, D.
10.1101/2022.02.25.482034 — plant biology — Posted on 2022-03-02
4110 Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells
Tidball, A. M.; Niu, W.; Ma, Q.; Takla, T. N.; Walker, J. C.; Margolis, J. L.; Mojica-Perez, S. P.; Sudyk, R.; Moore, S. J.; Chopra, R.; Shakkottai, V. G.; Murphy, G. G.; Li, J. Z.; Parent, J. M.
10.1101/2022.02.28.482350 — neuroscience — Posted on 2022-03-02
4114 Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells
Kikuchi, K.; Sakamoto, Y.; Uezu, A.; Yamamoto, H.; Ishiguro, K.-i.; Shimamura, K.; Saito, T.; Hisanaga, S.-i.; Nakanishi, H.
10.1101/2021.10.27.466197 — cell biology — Posted on 2022-03-02
4115 Spatially distributed computation in cortical circuits
Gepshtein, S.; Pawar, A.; Kwon, S.; Savel'ev, S.; Albright, T. D.
10.1101/2021.12.13.472322 — neuroscience — Posted on 2022-03-01
4119 Widening the landscape of transcriptional regulation of algal photoprotection
Arend, M.; Yuan, Y.; Ruiz-Sola, M. A.; Omranian, N.; Nikoloski, Z.; Petroutsos, D.
10.1101/2022.02.25.482034 — plant biology — Posted on 2022-03-01
4121 What the Phage: A scalable workflow for the identification and analysis of phage sequences
Marquet, M.; Hölzer, M.; Pletz, M. W.; Viehweger, A.; Makarewicz, O.; Ehricht, R.; Brandt, C.
10.1101/2020.07.24.219899 — bioinformatics — Posted on 2022-03-01
4122 One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: relation to chromosomal dosage
Vione, B.; Locatelli, C.; Zavaroni, G.; Piano, A.; La Rocca, G.; Caracausi, M.; Vitale, L.; Piovesan, A.; Gori, C.; Pirazzoli, G.; Strippoli, P.; Cocchi, G.; Ramacieri, G.; Pelleri, M. C.; Antonaros, F.
10.1101/2021.11.30.470411 — genetics — Posted on 2022-03-01
4124 Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart
Siatra, P.; Vatsellas, G.; Chatzianastasiou, A.; Balafas, E.; Manolakou, T.; Papapetropoulos, A.; Agapaki, A.; Mouchtouri, E.-T.; Korovesi, A. G.; Mavroidis, M.; Thanos, D.; Beis, D.; Kokkinopoulos, I.
10.1101/2022.01.28.473428 — cell biology — Posted on 2022-03-01
4126 Diverse innate immune factors protect yeast from lethal viral pathogenesis
Chau, S.; Gao, J.; Diao, A. J.; Cao, S. B.; Davidson, A. R.; Meneghini, M. D.
10.1101/2022.02.14.480455 — microbiology — Posted on 2022-03-01
4129 Cortical network structure mediates response to stimulation: An optogenetic study in non-human primate cortex
Bloch, J.; Greaves-Tunnell, A.; Shea-Brown, E.; Harchaoui, Z.; Shojaie, A.; Yazdan-Shahmorad, A.
10.1101/2021.05.17.444526 — neuroscience — Posted on 2022-03-01
4130 Orthogonal synthetases for polyketide precursors
Fricke, R.; Swenson, C.; Roe, L. T.; Hamlish, N.; Ad, O.; Smaga, S.; Gee, C. L.; Schepartz, A.
10.1101/2022.02.28.482149 — synthetic biology — Posted on 2022-03-01
4131 Optimization of the TeraTox assay for preclinical teratogenicity assessment
Jaklin, M.; Zhang, J. D.; Schaefer, N.; Clemann, N.; Barrow, P.; Kueng, E.; Sach-Peltason, L.; McGinnis, C.; Leist, M.; Kustermann, S.
10.1101/2021.07.06.451364 — pharmacology and toxicology — Posted on 2022-03-01
4132 Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Lyapina, E.; Marin, E.; Gusach, A.; Orekhov, P.; Gerasimov, A.; Luginina, A.; Vakhrameev, D.; Ergasheva, M.; Kovaleva, M.; Khusainov, G.; Khorn, P.; Shevtsov, M.; Kovalev, K.; Okhrimenko, I.; Popov, P.; Hu, H.; Weierstall, U.; Liu, W.; Cho, Y.; Gushchin, I.; Rogachev, A.; Bourenkov, G.; Park, S.; Park, G.; Hyun, H. J.; Park, J.; Gordeliy, V.; Borshchevskiy, V.; Mishin, A.; Cherezov, V.
10.1101/2022.02.25.480536 — biophysics — Posted on 2022-03-01
4133 Non-Newtonian Blood Rheology Impacts Left Atrial Stasis in Patient-Specific Simulations
Gonzalo, A.; Garcia-Villalba, M.; Rossini, L.; Duran, E.; Vigneault, D.; Martinez-Legazpi, P.; Flores, O.; Bermejo, J.; McVeigh, E.; Kahn, A.; del Alamo, J. C.
10.1101/2021.06.24.449801 — bioengineering — Posted on 2022-03-01
4134 Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing
Buhagiar, A. F.; McCool, M. A.; Bryant, C. J.; Abriola, L.; Surovtseva, Y. V.; Baserga, S. J.
10.1101/2022.03.01.482553 — biochemistry — Posted on 2022-03-01
4136 Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sex
Ocanas, S. R.; Ansere, V. A.; Tooley, K. B.; Hadad, N.; Chucair-Elliott, A. J.; Stanford, D. R.; Rice, S.; Wronowski, B.; Pham, K. D.; Hoffman, J. M.; Austad, S. N.; Stout, M. B.; Freeman, W. M.
10.1101/2021.09.01.458115 — genomics — Posted on 2022-03-01
4142 REM sleep promotes bidirectional plasticity in developing visual cortex in vivo
Renouard, L.; Hayworth, C.; Rempe, M.; Clegern, W.; Wisor, J.; Frank, M. G.
10.1101/2022.01.21.477249 — neuroscience — Posted on 2022-03-01
4143 Loss of functional heterogeneity along the CA3 transverse axis in aging
Lee, H.; Wang, Z.; Tilekeratne, A.; Lukish, N.; Zeger, S.; Gallagher, M.; Knierim, J. J.
10.1101/2021.09.14.460329 — neuroscience — Posted on 2022-03-01
4145 Cryo-EM structure of the Rhodobaca bogoriensis RC-LH1-PufX dimeric complex at 2.9 A
Semchonok, D. A.; Siponen, M. I.; Tueting, C.; Charras, Q.; Kyrilis, F. L.; Sadian, Y.; Jungas, C.; Kastritis, P. L.
10.1101/2022.02.25.481955 — biophysics — Posted on 2022-03-01
4146 Can single-component protein condensates form multiphase architectures?
Garaizar Suarez, A.; R Espinosa, J.; Joseph, J. A.; Krainer, G.; Shen, Y.; Knowles, T. P. J.; Collepardo-Guevara, R.
10.1101/2021.10.09.463670 — biophysics — Posted on 2022-03-01
4148 Stable nebulization and muco-trapping properties of Regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19
McSweeney, M. D.; Stewart, I.; Richardson, Z.; Kang, H.; Park, Y.; Kim, C.; Tiruthani, K.; Wolf, W.; Schaefer, A.; Kumar, P.; Aurora, H.; Hutchins, J.; Cho, J. M.; Hickey, A. J.; Lee, S. Y.; Lai, S. K.
10.1101/2022.02.27.482162 — bioengineering — Posted on 2022-03-01
4150 A BALB/c IGHV Reference Set, defined by haplotype analysis of long-read VDJ-C sequences from F1 (BALB/c / C57BL/6) mice
Jackson, K. J.; Kos, J. T.; Lees, W.; Gibson, W. S.; Smith, M. L.; Peres, A.; Yaari, G.; Corcoran, M.; Busse, C. E.; Ohlin, M.; Watson, C. T.; Collins, A. M.
10.1101/2022.02.28.482396 — immunology — Posted on 2022-03-01
4151 The nuclear receptor NR4A1 restrains neutrophil granulocyte mediated brain damage in cerebral ischemia
Strecker, J.-K.; Revenstorff, J.; Beuker, C.; Schmidt-Pogoda, A.; Hucke, S.; Liebmann, M.; Vogl, T.; Roth, J.; Thomas, C.; Kuhlmann, T.; Wiendl, H.; Klotz, L.; Minnerup, J.
10.1101/2022.02.27.482146 — neuroscience — Posted on 2022-03-01
4152 Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A
Joensuu, M.; Lanoue, V.; Syed, P.; Wallis, T. P.; Rae, J.; Blum, A.; Gormal, R.; Small, C.; Sanders, S.; Jiang, A.; Mahrhold, S.; Krez, N.; Cousin, M. A.; Cooper-White, R.; Cooper-White, J. J.; Collins, B. A.; Parton, R. G.; Balistreri, G.; Rummel, A.; Meunier, F. A.
10.1101/2022.02.28.482398 — neuroscience — Posted on 2022-03-01
4153 C21orf2 mutations found in ALS disrupt primary cilia function
De Decker, M.; Zelina, P.; Moens, T. G.; Eggermont, K.; Moisse, M.; Veldink, J. H.; Pasterkamp, R. J.; Van Damme, P.
10.1101/2022.02.28.482239 — neuroscience — Posted on 2022-03-01
4156 Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal
Roushar, F. J.; McKee, A. G.; Kuntz, C. P.; Ortega, J. T.; Penn, W. D.; Woods, H.; Chamness, L. M.; Most, V.; Meiler, J.; Jastrzebska, B.; Schlebach, J. P.
10.1101/2022.03.01.482516 — biochemistry — Posted on 2022-03-01
4157 The periplasmic chaperone Skp prevents misfolding of the secretory lipase A from Pseudomonas aeruginosa
Papadopoulos, A.; Busch, M.; Reiners, J.; Hachani, E.; Baeumers, M.; Schmitt, L.; Jaeger, K.-E.; Kovacic, F.; Smits, S. H.; Kedrov, A.
10.1101/2022.03.01.482502 — biochemistry — Posted on 2022-03-01
4158 Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing
Buhagiar, A. F.; McCool, M. A.; Bryant, C. J.; Abriola, L.; Surovtseva, Y. V.; Baserga, S. J.
10.1101/2022.03.01.482553 — biochemistry — Posted on 2022-03-01
4164 Metabolome and transcriptome analysis reveal components regulating soapberry triterpenoid saponin biosynthesis
Xu, Y.; Zhao, G.; Ji, X.; Liu, J.; Zhao, T.; Gao, Y.; Gao, S.; Hao, Y.; Gao, Y.; Wang, L.; Weng, X.; Chen, Z.; Jia, L.
10.1101/2022.02.28.482332 — molecular biology — Posted on 2022-03-01
4166 RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2
Vesuna, F.; Akhrymuk, I.; Smith, A.; Winnard, P. T.; Lin, S.-C.; Scharpf, R.; Kehn-Hall, K.; Raman, V.
10.1101/2022.02.28.482334 — microbiology — Posted on 2022-03-01
4167 Time-Dependent Increase in Susceptibility and Severity of Secondary Bacterial Infection during SARS-CoV-2 Infection
Smith, A. P.; Williams, E.; Plunkett, T.; Selvaraj, M.; Lane, L.; Zalduondo, L.; Xue, Y.; Vogel, P.; Channappanavar, R.; Jonsson, C.; Smith, A.
10.1101/2022.02.28.482305 — microbiology — Posted on 2022-03-01
4169 Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates
Wu, Y.; Shen, Y.; Wu, N.; Zhang, X.; Chen, S.; Yang, C.; Zhou, J.; Wu, Y.; Chen, D.; Wang, L.; Wang, Y.; Xu, J.; Liu, K.; Wang, C.; Zhang, H.; Xia, N.; Chiu, S.; Wang, Y.
10.1101/2022.03.01.481391 — microbiology — Posted on 2022-03-01
4171 dSeqSb: A systems biology approach to decipher dynamics of 1 host-pathogen interactions using temporal dual RNA-seq data
Dinarvand, M.; Koch, F.; Mouiee, D. A.; Vuong, K.; Vijayan, A.; Tanzim, A. F.; Azad, A.; Penesyan, A.; Castano-Rodriguez, N.; Vafaee, F.
10.1101/2022.02.28.482417 — microbiology — Posted on 2022-03-01
4172 Isolation of a potently neutralizing and protective human monoclonal antibody targeting yellow fever virus
Crowe, J. E.; Doyle, M.; Genualdi, J. R.; Bailey, A.; Kose, N.; Gainza, C.; Rodriguez, J.; Reeder, K. M.; Nelson, C. A.; Jethva, P. N.; Sutton, R. E.; Bombardi, R. G.; Gross, M.; Julander, J. G.; Fremont, D. H.; Diamond, M.
10.1101/2022.02.28.482437 — immunology — Posted on 2022-03-01
4173 A single episode of CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire
Hassan, N.; Eldershaw, S.; Stephens, C.; Kinsella, F.; Craddock, C.; Malladi, R.; Zuo, J.; Moss, P.
10.1101/2022.02.28.482225 — immunology — Posted on 2022-03-01
4174 Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Taylor, L.; von Lendenfeld, F.; Ashton, A.; Sanghani, H.; Tam, E.; Usselmann, L.; Verennetikova, M.; Dallmann, R.; McKeating, J.; Vasudevan, S.; Jagannath, A.
10.1101/2022.02.28.482377 — neuroscience — Posted on 2022-03-01
4175 Orthogonal synthetases for polyketide precursors
Schepartz, A.; Fricke, R.; Swenson, C.; Roe, L. T.; Hamlish, N.; Ad, O.; Smaga, S.; Gee, C. L.
10.1101/2022.02.28.482149 — synthetic biology — Posted on 2022-03-01
4177 STING activation promotes robust immune response and tumor regression in glioblastoma models
Berger, G.; Knelson, E. H.; Nowicki, M. O.; Han, S.; Jimenez-Macias, J. L.; Lizotte, P. H.; Adu-Berchie, K.; Stafford, A.; Dimitrikakis, N.; Chiocca, E. A.; Mooney, D. J.; Barbie, D. A.; Lawler, S. E.
10.1101/2022.02.28.481908 — cancer biology — Posted on 2022-03-01
4180 A quantitative method for sizing hyaluronan and other glycosaminoglycans on surfaces
Srimasorn, S.; Souter, L.; Green, D. E.; Djerbal, L.; Goodenough, A.; Duncan, J. A.; Roberts, A. R. E.; Zhang, X.; Debarre, D.; DeAngelis, P. L.; Kwok, J. C. F.; Richter, R. P.
10.1101/2022.02.28.482386 — biophysics — Posted on 2022-03-01
4188 Increased reliability of visually-evoked activity in area V1 of the MECP2-duplication mouse model of autism
Ash, R. T.; Palagina, G.; Park, J.; Fernandez-Leon, J. A.; Seilheimer, R.; Lee, S.; Froudarakis, E.; Tan, Z. H.; Sabharwal, J.; Wang, J.; Lu, D.; Wu, S.; Smirnakis, S. M.
10.1101/2022.02.27.482189 — neuroscience — Posted on 2022-03-01
4190 Social cues of safety can override differences in threat level
Ferreira, C. H.; Heinemans, M.; Farias, M.; Goncalves, R.; Moita, M.
10.1101/2022.02.27.481960 — neuroscience — Posted on 2022-03-01
4191 Assessment of dynamics of global DNA methylation during the cryopreservation process of Pinus pinaster embryogenic lines
Poudereux, I. M.; Cano, M.; Solis, M. T.; Esteve-Diaz, F.; Testillano, P. S.; Segura, J.; Sales, E.; Arrillaga, I.
10.1101/2022.02.27.481657 — plant biology — Posted on 2022-03-01
4192 A2A Receptor contributes to tumor progression in P2X7 null mice
De Marchi, E.; Pegoraro, A.; Turiello, R.; Di Virgilio, F.; Morello, S.; Adinolfi, E.
10.1101/2022.02.28.482298 — cancer biology — Posted on 2022-03-01
4194 In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia
Stitelman, D.; Ullrich, S.; Yung, N.; Bauer-Pisani, T.; Maassel, N.; Guerra, M. E.; Freedman-Weiss, M.; Ahle, S.; Ricciardi, A.; Sauler, M.; Saltzman, W. M.; Piotrowski-Daspit, A.
10.1101/2022.02.27.482144 — bioengineering — Posted on 2022-03-01
4196 IGF2BP1/IMP1 contributes to autophagy modulation directly via MAP1LC3B
Williams, P. A.; Parham, L. R.; Acheampong, K.; Danan, C. H.; Ma, X.; Simon, L. A.; Naughton, K. E.; Karakasheva, T.; Whelan, K. A.; Brady, D. C.; Shaffer, S. M.; Hamilton, K. E.
10.1101/2022.02.28.482365 — cell biology — Posted on 2022-03-01
4197 Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration
Jiang, F.-Q.; Chen, J.-X.; Chen, W.-Y.; Zhao, W.-L.; Song, G.-H.; Liang, C.-Q.; Zhou, Y.-M.; Huang, H.-L.; Huang, R.-J.; Zhao, H.; Park, K.-S.; Ju, Z.; Cai, D.; Qi, X.-F.
10.1101/2022.02.27.482166 — cell biology — Posted on 2022-03-01
4198 Anatomical structures, cell types, and biomarkers of the healthy human blood vasculature
Boppana, A.; Lee, S.; Malhotra, R.; Halushka, M.; Quardokus, E. M.; Herr, B. W.; Börner, K.; Weber, G. M.
10.1101/2022.02.28.482302 — cell biology — Posted on 2022-03-01
4199 The laminin-keratin link shields the nucleus from mechanical deformation and signalling
Kechagia, Z.; Saez, P.; Gomez-Gonzalez, M.; Zamarbide, M.; Andreu, I.; Koorman, T.; Beedle, A. E. M.; Derksen, P. W. B.; Trepat, X.; Arroyo, M.; Roca-Cusachs, P.
10.1101/2022.03.01.482474 — cell biology — Posted on 2022-03-01
4200 Identification of protein aggregates in the aging vertebrate brain with prion-like andphase separation properties
Harel, I.; Chen, Y. R.; Ziv, I.; Singh, P. P.; Navarro Negredo, P.; Goshtchevsky, U.; Wang, W.; Astre, G.; Moses, E.; McKay, A.; Machado, B. E.; Hebestreit, K.; Yin, S.; Sanchez Alvarado, A.; Jarosz, D. F.; Brunet, A.
10.1101/2022.02.26.482115 — neuroscience — Posted on 2022-03-01
4204 CLE42 Delays Leaf Senescence by Antagonizing Ethylene Pathway in Arabidopsis
Zhang, Y.; Tan, S.; Gao, Y.; Kan, C.; Wang, H.-L.; Yang, Q.; Xia, X.; Ishida, T.; Sawa, S.; Guo, H.; Li, Z.
10.1101/2022.02.27.481379 — plant biology — Posted on 2022-03-01
4206 Single-cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival
Wu, H.; Jin, W.; Zhang, Y.-H.; Liu, Z.; Chen, Z.; Xu, J.; Tian, Y.; Jin, W.; Wong, S. Z. H.; Wu, Q.-F.
10.1101/2022.02.26.482082 — bioinformatics — Posted on 2022-03-01
4208 MemBrain: A Deep Learning-aided Pipeline for Automated Detection of Membrane Proteins in Cryo-electron Tomograms
Lamm, L.; Righetto, R. D.; Wietrzynski, W.; Poege, M.; Martinez-Sanchez, A.; Peng, T.; Engel, B. D.
10.1101/2022.03.01.480844 — bioinformatics — Posted on 2022-03-01
4209 Assessing temporal and geographic contacts across the Adriatic Sea through the analysis of genome-wide data from Southern Italy
Raveane, A.; Molinaro, L.; Aneli, S.; Capodiferro, M. R.; Ongaro, L.; Rambaldi Migliore, N.; Soffiati, S.; Scarano, T.; Torroni, A.; Achilli, A.; Ventura, M.; Pagani, L.; Capelli, C.; Olivieri, A.; Bertolini, F.; Semino, O.; Montinaro, F.
10.1101/2022.02.26.482072 — genomics — Posted on 2022-03-01
4210 A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in histologically healthy tissues.
Luijts, T.; Elliott, K.; Siaw, J. T.; Van de Velde, J.; Beyls, E.; Claeys, A.; Lammens, T.; Larsson, E.; Willaert, W.; Vral, A.; Van den Eynden, J.
10.1101/2022.02.27.482170 — genomics — Posted on 2022-03-01
4211 Environmental DNA reflects common haplotypic variation
Adams, C. I. M.; Hepburn, C.; Jeunen, G.-J.; Cross, H.; Taylor, H. R.; Gemmell, N. J.; Bunce, M.; Knapp, M.
10.1101/2022.02.26.481856 — genetics — Posted on 2022-03-01
4212 Interactions of C. elegans -tubulins with the microtubule inhibitor albendazole
Mains, P. E.; Pallotto, L. M.; Dilks, C. M.; Park, Y.-J.; Smit, R. B.; Lu, B.; Gopalakrishnan, C.; Gilleard, J. S.; Andersen, E. C.
10.1101/2022.02.27.482202 — genetics — Posted on 2022-03-01
4214 A pleiotropic flowering time QTL exhibits gene-by-environmental interaction for fitness in a perennial grass
Weng, X.; Haque, T.; Zhang, L.; Razzaque, S.; Lovell, J. T.; Palacio-Mejia, J. D.; Duberney, P.; Reilley, J. L.; Bonnette, J.; Juenger, T. E.
10.1101/2022.02.26.482116 — evolutionary biology — Posted on 2022-03-01
4217 Nrf2 promotes thyroid development and hormone synthesis.
Gillotay, P.; Romitti, M.; Dassy, B.; Haerlingen, B.; Shankar, M. P.; Da Fonseca, B. D. F.; Ziros, P. G.; Singh, S. P.; Sykiotis, G.; costagliola, s.
10.1101/2022.02.27.482168 — developmental biology — Posted on 2022-03-01
4218 Four novel, immortal cell lines derived from embryos of Xenopus tropicalis
Gorbsky, G. J.; Daum, J. R.; Sapkota, H.; Summala, K.; Yoshida, H.; Georgescu, C.; Wren, J. D.; Peshkin, L.; Horb, M. E.
10.1101/2022.03.01.482505 — cell biology — Posted on 2022-03-01
4219 BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes
Strash, N.; Deluca, S.; Carattini, G. L. J.; Chen, Y.; Scherba, J.; Jain, M.; Naseri, R.; Wu, T.; Bursac, N.
10.1101/2022.02.28.482357 — cell biology — Posted on 2022-03-01
4221 Realtime morphological characterization and sorting of unlabeled viable cells using deep learning
Salek, M.; Li, N.; Chou, H.-P.; Saini, K.; Jovic, A.; Jacobs, K. B.; Johnson, C.; Lee, E. J.; Chang, C.; Nguyen, P.; Mei, J.; Pant, K. P.; Wong-Thai, A. Y.; Smith, Q. F.; Huang, S.; Chow, R.; Cruz, J.; Walker, J.; Chan, B.; Musci, T. J.; Ashley, E. A.; Masaeli, M.
10.1101/2022.02.28.482368 — cell biology — Posted on 2022-03-01
4222 ATM modulates nuclear mechanics by regulating lamin A levels
Shah, P.; McGuigan, C. W.; Cheng, S.; Vanpouille-Box, C. I.; Demaria, S.; Weiss, R. S.; Lammerding, J.
10.1101/2022.02.28.482418 — cell biology — Posted on 2022-03-01
4223 HIF-1α induces glycolytic reprogramming in tissue-resident alveolar macrophagesto promote survival during acute lung injury
Woods, P. S.; Kimmig, L. M.; Sun, K. A.; Meliton, A. Y.; Shamaa, O. R.; Tian, Y.; Cetin-Atalay, R.; Sharp, W. W.; Hamanaka, R. B.; Mutlu, G. M.
10.1101/2022.02.28.482301 — cell biology — Posted on 2022-03-01
4224 Human MAIT cells show clonal diversity but transcriptional and functional homogeneity
Garner, L. C.; Amini, A.; FitzPatrick, M. E. B.; Provine, N. M.; Klenerman, P.
10.1101/2022.02.26.482031 — immunology — Posted on 2022-03-01
4225 A novel lineage of RORγt+Aire+ antigen presenting cells promotes peripheral generation of intestinal regulatory T cells and tolerance during early life
Akagbosu, B.; Tayyebi, Z.; Shibu, G.; Paucar Iza, Y. A.; Deep, D.; Franco Parisotto, Y.; Pasolli, H. A.; Elmentaite, R.; Knott, M.; Hemmers, S.; Jahn, L.; Friedrich, C.; Verter, J.; van den Brink, M.; Gasteiger, G.; Grünewald, T. G. P.; Leslie, C.; Rudensky, A. Y.; Brown, C. C.
10.1101/2022.02.26.481148 — immunology — Posted on 2022-03-01
4226 Macrophage depletion blocks congenital SARM1-dependent neuropathy
Dingwall, C. B.; Strickland, A.; Yum, S. W.; Yim, A. K. Y.; Zhu, J.; Wang, P. L.; Yamada, Y.; Schmidt, R. E.; Sasaki, Y.; Bloom, J.; DiAntonio, A.; Milbrandt, J.
10.1101/2022.02.26.482110 — neuroscience — Posted on 2022-03-01
4227 High cardiomyocyte diversity in human early prenatal heart development
Sylven, C.; Wardell, E.; Mansson, A.; Cingolani, E.; Ampatzis, K.; Larsson, L.; Bjorklund, A.; Giacomello, S.
10.1101/2022.02.26.482029 — systems biology — Posted on 2022-03-01
4228 Pan-cancer proteomic map of 949 human cell lines reveals principles of cancer vulnerabilities
Goncalves, E.; Poulos, R. C.; Cai, Z.; Barthorpe, S.; Manda, S.; Lucas, N.; Beck, A.; Bucio-Noble, D.; Dausmann, M.; Hall, C.; Hecker, M.; Koh, J.; Mahboob, S.; Mali, I.; Morris, J.; Richardson, L.; Seneviratne, A. J.; Sykes, E.; Thomas, F.; Valentini, S.; Williams, S. G.; Wu, Y.; Xavier, D.; MacKenzie, K.; Hains, P. G.; Tully, B.; Robinson, P. J.; Zhong, Q.; Garnett, M. J.; Reddel, R. R.
10.1101/2022.02.26.482008 — systems biology — Posted on 2022-03-01
4229 Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate
Chen, Y. R.; Harel, I.; Singh, P. P.; Ziv, I.; Moses, E.; Goshtchevsky, U.; Machado, B. E.; Brunet, A.; Jarosz, D. F.
10.1101/2022.02.26.482120 — systems biology — Posted on 2022-03-01
4234 Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes
Gouveia, B.; Setru, S. U.; King, M. R.; Stone, H. A.; Shaevitz, J. W.; Petry, S.
10.1101/2022.02.28.482415 — biophysics — Posted on 2022-03-01
4235 Tween-20 induces the structural remodelling of single lipid vesicles
Dresser, L. G.; Graham, S. P.; Miller, L. M.; Schaefer, C.; Conteduca, D.; Johnson, S.; Leake, M. C.; Quinn, S. D.
10.1101/2022.03.01.482482 — biophysics — Posted on 2022-03-01
4237 Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome
Dinstag, G.; Shulman, E. D.; Elis, E.; Ben-Zvi, D. S.; Tirosh, O.; Maimon, E.; Meilijson, I.; Elalouf, E.; Schiff, E.; Hoang, D.-T.; Sinha, S.; Nair, N. U.; Sang Lee, J.; Schaffer, A. A.; Ronai, Z.; Juric, D.; Apolo, A. B.; Dahut, W. L.; Lipkowitz, S.; Berger, R.; Kurzrock, R.; Papanicolau-Sengos, A.; Karzai, F.; Gilbert, M. R.; Aldape, K.; Rajagopal, P. S.; Beker, T.; Ruppin, E.; Aharonov, R.
10.1101/2022.02.27.481627 — bioinformatics — Posted on 2022-03-01
4242 The role of floral traits in community assembly process at high elevations in Lesser Himalaya
Ahmad, M.; Rosbakh, S.; Bucher, S. F.; Sharma, P.; Rathee, S.; Uniyal, S. K.; Batish, D. R.; Singh, H. P.
10.1101/2022.02.26.482103 — ecology — Posted on 2022-03-01
4244 The sequences of 150,119 genomes in the UK biobank
Halldorsson, B. V.; Eggertsson, H. P.; Moore, K. H. S.; Hauswedell, H.; Eiriksson, O.; Ulfarsson, M. O.; Palsson, G.; Hardarson, M. T.; Oddsson, A.; Jensson, B. O.; Kristmundsdottir, S.; Sigurpalsdottir, B. D.; Stefansson, O. A.; Beyter, D.; Holley, G.; Tragante, V.; Gylfason, A.; Olason, P. I.; Zink, F.; Asgeirsdottir, M.; Sverrisson, S. T.; Sigurdsson, B.; Gudjonsson, S. A.; Sigurdsson, G. T.; Halldorsson, G. H.; Sveinbjornsson, G.; Norland, K.; Styrkarsdottir, U.; Magnusdottir, D. N.; Snorradottir, S.; Kristinsson, K.; Sobech, E.; Thorleifsson, G.; Jonsson, F.; Melsted, P.; Jonsdottir, I.;
10.1101/2021.11.16.468246 — genetics — Posted on 2022-03-01
4246 Dexamethasone, a direct modulator of AQP2 in Meniere s disease.
Mom, R.; Robert-Paganin, J.; Mom, T.; Chabbert, C.; Rety, S.; Auguin, D.
10.1101/2022.01.25.477763 — biochemistry — Posted on 2022-03-01
4247 Salient 40 Hz sounds probe affective aversion and neural excitability
Schneefeld, F.; Doelling, K. D.; Marchesotti, S.; Schwartz, S.; Igloi, K.; Giraud, A.-L.; Arnal, L. H.
10.1101/2022.02.26.482077 — neuroscience — Posted on 2022-03-01
4248 Numerical discrimination in Drosophila melanogaster
Bengochea, M.; Sitt, J. D.; Preat, T.; Izard, V.; Cohen, L.; Hassan, B. A.
10.1101/2022.02.26.482107 — neuroscience — Posted on 2022-03-01
4249 A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike
Fu, Y.; da Fonseca Rezende e Mello, J.; Fleming, B. D.; Renn, A.; Chen, C. Z.; Hu, X.; Xu, M.; Gorshkov, K.; Hanson, Q.; Zheng, W.; Lee, E. M.; Perera, L.; Petrovich, R.; Pradhan, M.; Eastman, R. T.; Itkin, Z.; Stanley, T.; Hsu, A.; Dandey, V.; Gillette, W.; Taylor, T.; Ramakrishnan, N.; Perkins, S.; Esposito, D.; Oh, E.; Susumu, K.; Wolak, M.; Ferrer, M.; Hall, M. D.; Borgnia, M. J.; Simeonov, A.
10.1101/2021.10.22.465476 — synthetic biology — Posted on 2022-03-01
4252 Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency
Sun, J.; Duan, Y.; Chen, J.; Meng, X.; Liu, L.; Shang, K.; Wu, X.; Wang, Y.; Huang, Z.; Liu, H.; Huang, Y.; Zhou, C.; Gao, X.; Wang, Y.; Sadelain, M.
10.1101/2022.03.01.482445 — immunology — Posted on 2022-03-01
4253 Quantitative imaging reveals PI3Kδ inhibition reduces rhinovirus-induced damage of small airway epithelia in ex vivo cultured human precision cut lung slices from COPD patients
Dvornikov, D.; Halavatyi, A.; Khan, M. M.; Zimmerman, N.; Cross, A.; Poeckel, D.; Melnikov, E.; Tischer, C. M.; Leyrer, J.; Schneider, M. A.; Muley, T.; Winter, H.; Hessel, E.; Beinke, S.; Pepperkok, R.
10.1101/2022.03.01.482451 — pathology — Posted on 2022-03-01
4254 Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels
Teng, B.; Kaplan, J.; Liang, Z.; Krieger, Z.; Tu, Y.-H.; Burendei, B.; Ward, A. B.; Liman, E.
10.1101/2022.03.01.482452 — biophysics — Posted on 2022-03-01
4255 Dark kinase annotation, mining and visualization using the Protein Kinase Ontology
Soleymani, S.; Gravel, N.; Huang, L.-C.; Yeung, W.; Bozorgi, E.; Bendzunas, N. G.; Kochut, K. J.; Kannan, N.
10.1101/2022.02.25.482021 — bioinformatics — Posted on 2022-03-01
4263 Rapid adaptation and range expansion in response to agriculture over the last two centuries
Kreiner, J. M.; Latorre, S. M.; Burbano, H. A.; Stinchcombe, J. R.; Otto, S. P.; Weigel, D.; Wright, S. I.
10.1101/2022.02.25.482047 — evolutionary biology — Posted on 2022-03-01
4264 Reconstructing the ancestral vertebrate brain using a lamprey neural cell type atlas
Lamanna, F.; Hervas-Sotomayor, F.; Oel, A. P.; Jandzik, D.; Sobrido-Camean, D.; Martik, M. L.; Green, S. A.; Brüning, T.; Mössinger, K.; Schmidt, J.; Schneider, C.; Sepp, M.; Murat, F.; Smith, J. J.; Bronner, M. E.; Rodicio, M. C.; Barreiro-Iglesias, A.; Meulemans Medeiros, D.; Arendt, D.; Kaessmann, H.
10.1101/2022.02.28.482278 — evolutionary biology — Posted on 2022-03-01
4265 Experimental evidence that animal societies vary in size due to sex differences in cooperation
Melgar, J.; Schou, M. F.; Bonato, M.; Brand, Z.; Engelbrecht, A.; Cloete, S. W.; Cornwallis, C. K.
10.1101/2022.03.01.482465 — evolutionary biology — Posted on 2022-03-01
4268 Model selection in occupancy models: inference versus prediction
Stewart, P. S.; Stephens, P. A.; Hill, R.; Whittingham, M. J.; Dawson, W.
10.1101/2022.03.01.482466 — ecology — Posted on 2022-03-01
4270 Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A.; Plewka, J.; Chykunova, Y.; Jones, A. N.; Pachota, M.; Rawski, M.; Mourao, A.; Karim, A.; Kresik, L.; Lis, K.; Minia, I.; Hartman, K.; Sonani, R.; Dubin, G.; Sattler, M.; Suder, P.; Mak, P.; Popowicz, G.; Pyrc, K.; Czarna, A.
10.1101/2022.01.25.477673 — microbiology — Posted on 2022-03-01
4271 Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants
Zarn, K. E.; Jaramillo, S. A.; Zapata, A. R.; Stone, N. E.; Jones, A. N.; Nunnally, H. E.; Settles, E. W.; Ng, K.; Keim, P. S.; Knudsen, S.; Nuijten, P. M.; Tijsma, A. S.; French, C. T.
10.1101/2021.11.03.467186 — microbiology — Posted on 2022-03-01
4274 The ITPRIPL1- CD3ϵ axis: a novel immune checkpoint controlling T cells activation
Deng, S.; Wang, Y.; Brosseau, J.-P.; Wang, Y.; Xu, K.; Chi, H.; Han, X.; Song, T.; Sun, Y.-F.; Wang, H.; Song, J.; Tao, W.; Wang, C.; Ye, R.; Shan, L.; Zhong, J.; Zhao, X.; Xu, Y.; He, F.; Li, H.; Xu, J.
10.1101/2022.02.25.481189 — immunology — Posted on 2022-03-01
4276 Hominoid-specific sulcal variability is related to face perception ability
Parker, B. J.; Voorhies, W. I.; Guo, J.; Miller, J. A.; Willbrand, E.; Hallock, T.; Furl, N.; Garrido, L.; Duchaine, B.; Weiner, K. S.
10.1101/2022.02.28.482330 — neuroscience — Posted on 2022-03-01
4293 Repurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer Immunotherapy
Nagalo, B. M.; Zhang, Y.; Taylor, M. A.; Simoes, C. C.; Dumbauld, C.; Gabere, M. N.; Barro, O.; Chamcheu, J. C.; Post, S. R.; Kelly, T. J.; Borad, M. J.; Cannon, M. J.; Basnakian, A.
10.1101/2022.02.25.481685 — immunology — Posted on 2022-03-01
4294 Mucosal microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients
Tran, H. N. H.; Nguyen Hoang Thu, T.; Nguyen, P. H.; Vo, C. N.; Doan, K. V.; Nguyen Ngoc Minh, C.; Nguyen, N. T.; Ta, V. N. D.; Vu, K. A.; Hua, T. D.; Nguyen, T. N. T.; Pham Duc, T.; Trinh Van, T.; Duong, B. L.; Nguyen, P. M.; Hoang, V. C.; Pham, D. T.; Thwaites, G.; Hall, L. J.; Slade, D. J.; Baker, S.; Tran, V. H.; Chung The, H.
10.1101/2022.02.25.481918 — microbiology — Posted on 2022-03-01
4296 Tie-lines reveal interactions driving heteromolecular condensate formation
Qian, D.; Welsh, T. J.; Erkamp, N. A.; Qamar, S. S.; Nixon-Abell, J.; Krainer, G.; St George-Hyslop, P.; Michaels, T.; Knowles, T.
10.1101/2022.02.22.481401 — biophysics — Posted on 2022-03-01
4300 On the reproductive mechanism of Gram-negative protocells
Kanaparthi, D.; Lampe, M.; Zhu, B.; Klingl, A.; Lueders, T.; Schwille, P.
10.1101/2021.11.25.470037 — biophysics — Posted on 2022-03-01
4305 Label-free three-photon imaging of intact human cerebral organoids: tracking early events in brain development and deficits in Rett Syndrome
Yildirim, M.; Delepine, C.; Feldman, D.; Pham, V.; Chou, S.; Ip, J.; Nott, A.; Tsai, L.-H.; Ming, G.-L.; So, P. T.; Sur, M.
10.1101/2022.02.28.482282 — neuroscience — Posted on 2022-03-01
4309 Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone
Genet, N.; Genet, G.; Fang, J. S.; Chavkin, N. W.; Vasavada, H. H.; Goldberg, J. S.; Acharya, B. R.; Bhatt, N.; Baker, K.; McDonnell, S.; Huba, M. R.; Ma, G.; Eichmann, A.; Thomas, J. L.; ffrench-constant, C.; Hirschi, K. K.
10.1101/2022.02.28.482353 — neuroscience — Posted on 2022-03-01