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Archive, 2020-04

2 Zygomorphic flowers have fewer visitors
Yoder, J. B.; Gomez, G.; Carlson, C. J.
10.1101/743872 — ecology — Posted on 2020-04-30
3 Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells
O'Callaghan, P.; Engberg, A.; Fatsis-Kavalopoulos, N.; Sanchez, G.; Idevall-Hagren, O.; Kreuger, J.
10.1101/2020.04.30.068338 — cell biology — Posted on 2020-04-30
6 Critical Residues of Gβγ for the interaction with the SNARE Complex
Mueller, B. K.; Kaya, A. I.; Zurawski, Z.; Yim, Y. Y.; Meiler, J.; Hamm, H. E.
10.1101/2020.04.29.069187 — biochemistry — Posted on 2020-04-30
7 Individual differences in haemoglobin concentration influence BOLD fMRI functional connectivity and its correlation with cognition
Ward, P. G. D.; Orchard, E. R.; Oldham, S.; Arnatkeviciute, A.; Sforazzini, F.; Fornito, A.; Egan, G.; Jamadar, S. D.
10.1101/835660 — neuroscience — Posted on 2020-04-30
9 Functional and genetic markers of niche partitioning among enigmatic members of the human oral microbiome
Shaiber, A.; Willis, A. D.; Delmont, T. O.; Roux, S.; Chen, L.-X.; Schmid, A. C.; Yousef, M.; Watson, A. R.; Lolans, K.; Esen, O. C.; Lee, S. T.; Downey, N.; Morrison, H. G.; Dewhirst, F.; Mark Welch, J. L.; Eren, A. M.
10.1101/2020.04.29.069278 — microbiology — Posted on 2020-04-30
10 Structural basis of Rgg protein binding to their regulatory pheromones and target DNA promoters
Capodagli, G. C.; Tylor, K. M.; Kaelber, J. T.; Petrou, V. I.; Federle, M. J.; Neiditch, M. B.
10.1101/2020.04.30.069369 — microbiology — Posted on 2020-04-30
11 Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection
Grier, A.; Gill, A. L.; Kessler, H. A.; Corbett, A.; Bandyopadhyay, S.; Java, J.; Holden-Wiltse, J.; Falsey, A. R.; Topham, D. J.; Mariani, T. J.; Caserta, M. T.; Walsh, E. E.; Gill, S. R.
10.1101/2020.04.30.071258 — microbiology — Posted on 2020-04-30
13 The knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs
Kurtz, S.; Lucas-Hahn, A.; Schlegelberger, B.; Goehring, G.; Niemann, H.; Mettenleiter, T. C.; Petersen, B.
10.1101/617589 — developmental biology — Posted on 2020-04-30
16 Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate
Allmeroth, K.; Kim, C. S.; Annibal, A.; Pouikli, A.; Chacon-Martinez, C. A.; Latza, C.; Antebi, A.; Tessarz, P.; Wickström, S. A.; Denzel, M. S.
10.1101/2020.04.30.070201 — cell biology — Posted on 2020-04-30
17 Impairment of the Gβγ-SNAP25 brake on exocytosis enhances insulin action, protects against diet-induced obesity, and promotes adipocyte browning
Ceddia, R. P.; Zurawski, Z.; Thompson Gray, A.; Adegboye, F.; Shi, F.; Liu, D.; McGuinness, O. P.; Collins, S.; Hamm, H. E.
10.1101/2020.04.29.069138 — physiology — Posted on 2020-04-30
20 De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function.
Wu, R.; Chen, X.; Kang, S.; Wang, T.; Gnanaprakasam, J. R.; Yao, Y.; Liu, L.; Zheng, S.; Fan, G.; Burns, M.; Wang, R.
10.1101/2020.04.29.068759 — cell biology — Posted on 2020-04-30
26 Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects
Landers, C. C.; Rabeler, C. A.; Ferrari, E. K.; D'Alessandro, L. R.; Kang, D. D.; Malisa, J.; Bashir, S. M.; Carone, D. M.
10.1101/2020.04.30.064329 — cell biology — Posted on 2020-04-30
27 Mechanochemical control of epidermal stem cell divisions by B-plexins
Jiang, C.; Javed, A.; Kaiser, L.; Nava, M. M.; Zhao, D.; Brandt, D. T.; Fernandez-Baldovinos, J.; Zhou, L.; Hoess, C.; Sawmynaden, K.; Oleksy, A.; Matthews, D.; Weinstein, L. S.; Groene, H.-J.; Niessen, C. M.; Offermanns, S.; Wickstrom, S. A.; Worzfeld, T.
10.1101/2020.04.30.070359 — cell biology — Posted on 2020-04-30
29 The mistletoe Struthanthus flexicaulis reduces dominance and increases diversity of plants in campo rupestre
Monteiro, G. F.; Barbosa, M.; Antonini, Y.; de Oliveira Passos, M. F.; Novais, S.; Fernandes, G. W.
10.1101/2020.04.30.070268 — ecology — Posted on 2020-04-30
31 YTHDF2 is essential for spermatogenesis and fertility through mediating a wave of transcript transition during spermatogonial differentiation
Zhao, X.; Lin, Z.; Fan, Y.; Zhang, Y.-J.; Li, F.; Hong, T.; Feng, H.; Tong, M.-H.; Wang, N.-L.; Kuang, Y.-P.; Lyu, Q.-F.
10.1101/2020.04.30.070235 — genetics — Posted on 2020-04-30
32 Identification of variable sites in Sars-CoV-2 and their abundance profiles in time
Comandatore, F.; Chiodi, A.; Gabrieli, P.; Biffignandi, G. B.; Perini, M.; Ramazzotti, M.; Ricagno, S.; Rimoldi, S. G.; Gismondo, M.; Micheli, V.; Bandi, C.; Brilli, M.
10.1101/2020.04.30.071027 — bioinformatics — Posted on 2020-04-30
34 Molecular epidemiology of mumps viruses detected in the Netherlands, 2017-2019
Bodewes, R.; Reijnen, L.; Kerkhof, J.; Cremer, J.; Schmitz, D.; van Binnendijk, R.; Veldhuijzen, I.
10.1101/2020.04.30.070243 — microbiology — Posted on 2020-04-30
35 Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator
Ankri, S.; Nagaraja, S.; Cai, M. W.; Sarid, L.; Shaulov, Y.; Trebicz-Geffen, M.; Mazumdar, M.; Varet, H.; Legendre, R.; Coppee, J.-Y.; Dedon, P. C.; Gourinath, S.; Guillen, N.; Saito-Nakano, Y.; Shimokawa, C.; Hisaeda, H.
10.1101/2020.04.30.070276 — microbiology — Posted on 2020-04-30
36 Origin of imported SARS-CoV-2 strains in The Gambia identified from Whole Genome Sequences.
Kanteh, A.; Manneh, J.; Jabang, S.; Kujabo, M. A.; Sanyang, B.; Oboh, M. A.; Bojang, A.; Jallow, H. S.; Nwakama, D.; Secka, O.; Roca, A.; Amambua-Ngwa, A.; Antonio, M.; Baldeh, I.; Forest, K.; Samateh, A. L.; D'Alessandro, U.; Sesay, A. K.
10.1101/2020.04.30.070771 — genomics — Posted on 2020-04-30
38 Susceptibility of tree shrew to SARS-CoV-2 infection
Zhao, Y.; Wang, J.; Kuang, D.; Xu, J.; Yang, M.; Ma, C.; Zhao, S.; Li, J.; Long, H.; Ding, K.; Gao, J.; Liu, J.; Wang, H.; Li, H.; Yang, Y.; Yu, W.; Yang, J.; Zheng, Y.; Wu, D.; Lu, S.; Liu, H.; Peng, X.
10.1101/2020.04.30.029736 — microbiology — Posted on 2020-04-30
40 Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA
Lee, J. Y.; Best, N.; McAuley, J. L.; Porter, J.; Seemann, T.; Schultz, M. B.; Sait, M.; Orlando, N.; Mercoulia, K.; Ballard, S. A.; Druce, J.; Tran, T.; Catton, M.; Pryor, M. J.; Cui, H. L.; Luttick, A.; McDonald, S.; Greenhalgh, A.; Kwong, J. C.; Sherry, N. L.; Graham, M.; Hoang, T.; Herisse, M.; Pidot, S. J.; Williamson, D. A.; Howden, B. P.; Monk, I. R.; Stinear, T. P.
10.1101/2020.04.28.067363 — microbiology — Posted on 2020-04-30
42 Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
Heer, C. D.; Sanderson, D. J.; Alhammad, Y. M. O.; Schmidt, M. S.; Trammell, S. A. J.; Perlman, S.; Cohen, M. S.; Fehr, A. R.; Brenner, C.
10.1101/2020.04.17.047480 — microbiology — Posted on 2020-04-30
43 Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2
Korber, B.; Fischer, W.; Gnanakaran, S. G.; Yoon, H.; Theiler, J.; Abfalterer, W.; Foley, B.; Giorgi, E. E.; Bhattacharya, T.; Parker, M. D.; Partridge, D. G.; Evans, C. M.; de Silva, T.; LaBranche, C. C.; Montefiori, D. C.; Sheffield COVID-19 Genomics Group,
10.1101/2020.04.29.069054 — evolutionary biology — Posted on 2020-04-30
45 Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s
Joshi, J.; Beaudoin, G. A. W.; Patterson, J. A.; Garcia-Garcia, J. D.; Belisle, C. E.; Chang, L.-Y.; Li, L.; Duncan, O.; Millar, A. H.; Hanson, A. D.
10.1101/2020.04.29.067249 — plant biology — Posted on 2020-04-30
46 A mouse model for spinal muscular atrophy provides insights into non-alcoholic fatty liver disease pathogenesis
Deguise, M.-O.; Pileggi, C.; Beauvais, A.; Tierney, A.; Chehade, L.; De Repentigny, Y.; Michaud, J.; Llavero-Hurtado, M.; Lamont, D.; Atrih, A.; Wishart, T. M.; Gillingwater, T. H.; Schneider, B. L.; Harper, M.-E.; Parson, S. H.; Kothary, R.
10.1101/2020.04.29.051938 — pathology — Posted on 2020-04-30
53 Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog
Roberts, S.; Khera, E.; Choi, C.; Navaratna, T.; Grimm, J.; Thurber, G. M.; Reiner, T.
10.1101/2020.04.29.068619 — bioengineering — Posted on 2020-04-30
57 Plk4 triggers autonomous de novo centriole biogenesis and maturation
Nabais, C.; Pessoa, D.; de-Carvalho, J.; van Zanten, T.; Duarte, P.; Mayor, S.; Carneiro, J.; Telley, I. A.; Bettencourt Dias, M.
10.1101/2020.04.29.068650 — cell biology — Posted on 2020-04-30
58 CNCDatabase: a database of non-coding cancer drivers
Liu, E. M.; Martinez-Fundichely, A.; Bollapragada, R.; Spiwack, M.; Khurana, E.
10.1101/2020.04.29.069047 — cancer biology — Posted on 2020-04-30
61 Modern Machine Learning: Partition & Vote
Priebe, C. E.; Vogelstein, J.; Engert, F.; White, C. M.
10.1101/2020.04.29.068460 — neuroscience — Posted on 2020-04-30
63 Durable memories and efficient neural coding through mnemonic training using the method of loci
Wagner, I. C.; Konrad, B. N.; Schuster, P.; Weisig, S.; Repantis, D.; Ohla, K.; Kühn, S.; Fernandez, G.; Steiger, A.; Lamm, C.; Czisch, M.; Dresler, M.
10.1101/2020.04.29.067561 — neuroscience — Posted on 2020-04-30
64 An Axon-Pathfinding Mechanism Preserves Epithelial Tissue Integrity
Cammarota, C.; Finegan, T. M.; Wilson, T. J.; Yang, S.; Bergstralh, D. T.
10.1101/2020.04.29.068387 — cell biology — Posted on 2020-04-30
65 Single-cell analysis reveals mechanisms of plasticity of leukemia initiating cells
Morris, V.; Marion, W.; Hughes, T.; Sousa, P.; Sensharma, P.; Pikman, Y.; Harris, M.; Shalek, A. K.; North, T.; Daley, G. Q.; Lummertz da Rocha, E.; Rowe, G.
10.1101/2020.04.29.066332 — cancer biology — Posted on 2020-04-30
71 Gene expression profiling reveals subgenome dominance during Brassica napus seed development
Khan, D.; Ziegler, D.; Kalichuk, J. L.; Hoi, V.; Huynh, N.; Hajihasani, A.; Parkin, I. A. P.; Robinson, S.; Belmonte, M. F.
10.1101/2020.04.29.068189 — plant biology — Posted on 2020-04-30
72 Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation reveals multisite regulation of surface expression and gating
Lorenzini, M.; Burel, S.; Lesage, A.; Wagner, E.; Charriere, C.; Chevillard, P.-M.; Evrard, B.; Maloney, D.; Ruff, K. M.; Pappu, R. V.; Wagner, S.; Nerbonne, J. M.; Silva, J. R.; Townsend, R. R.; Maier, L. S.; Marionneau, C.
10.1101/2020.04.29.067835 — physiology — Posted on 2020-04-30
73 The habenula clock regulates response to a stressor
Basnakova, A.; Cheng, R.-K.; Chia, J. S. M.; Jesuthasan, S. J.
10.1101/2020.04.29.067108 — neuroscience — Posted on 2020-04-30
75 Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy
Jackson, J. S.; Johnson, J. D.; Meftah, S.; Murray, T. K.; Ahmed, Z.; Fasiolo, M.; Hutton, M. L.; Isaac, J. T.; O'Neill, M. J.; Ashby, M. C.
10.1101/2020.04.29.067629 — neuroscience — Posted on 2020-04-30
77 Does hippocampal volume explain performance differences on hippocampal-dependent tasks?
Clark, I. A.; Monk, A. M.; Hotchin, V.; Pizzamiglio, G.; Liefgreen, A.; Callaghan, M. F.; Maguire, E. A.
10.1101/2020.04.29.067611 — neuroscience — Posted on 2020-04-30
78 Cortical and subcortical hemodynamic changes during human sleep slow waves
Betta, M.; Handjaras, G.; Leo, A.; Federici, A.; Farinelli, V.; Ricciardi, E.; Siclari, F.; Meletti, S.; Ballotta, D.; Benuzzi, F.; Bernardi, G.
10.1101/2020.04.29.067702 — neuroscience — Posted on 2020-04-30
80 A novel single-domain Na+-selective voltage-gated channel in photosynthetic eukaryotes
Helliwell, K. E.; Chrachri, A.; Koester, J.; Wharam, S.; Taylor, A.; Wheeler, G.; Brownlee, C.
10.1101/2020.04.29.068528 — microbiology — Posted on 2020-04-30
83 Effects of gene by microbiome interactions on behavioral and neurobiological phenotypes in a mouse model for autism spectrum disorder
Osman, A.; Mervosh, N. L.; Strat, A. N.; Meckel, K. R.; Euston, T. J.; Zipursky, G. D.; Drapeau, E.; Buxbaum, J.; Breen, M. S.; Kiraly, D. D.
10.1101/2020.04.29.065821 — neuroscience — Posted on 2020-04-30
84 PCNA has specific functions in regulation of metabolism in haematological cells
Rost, L. M.; Olaisen, C.; Sharma, A.; Nedal, A.; Petrovic, V.; Kvitvang, H. F. N.; Bruheim, P.; Otterlei, M.
10.1101/2020.04.29.067512 — cell biology — Posted on 2020-04-30
87 Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Mills, L. J.; Scott, M.; Shah, P.; Cunanan, A. R.; Deshpande, A.; Auch, B.; Curtin, B.; Beckman, K. B.; Spector, L. G.; Sarver, A. L.; Subramanian, S.; Richmond, T.; Modiano, J. F.
10.1101/2020.04.29.068155 — cancer biology — Posted on 2020-04-30
88 Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease
Zhang, K.; Li, S.; Hsieh, K.-Y.; Su, S.-C.; Pintilie, G. D.; Chiu, W.; Chang, C.-I.
10.1101/2020.04.29.068361 — biophysics — Posted on 2020-04-30
95 Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility
Harvey, S.; Kumari, P.; Lapin, D.; Griebel, T.; Hickman, R.; Guo, W.; Zhang, R.; Parker, J. E.; Beynon, J.; Denby, K.; Steinbrenner, J.
10.1101/2020.04.29.066688 — plant biology — Posted on 2020-04-30
99 Network analysis prioritizes DEWAX and ICE1 as the candidate genes for two major eQTL hotspots in seed germination
Hartanto, M.; Joosen, R. V. L.; Snoek, B. L.; Willems, L. A. J.; Sterken, M. G.; de Ridder, D.; Hilhorst, H. W. M.; Ligterink, W.; Nijveen, H.
10.1101/2020.04.29.050567 — plant biology — Posted on 2020-04-30
100 Connectomes across development reveal principles of brain maturation in C. elegans
Witvliet, D.; Mulcahy, B.; Mitchell, J. K.; Meirovitch, Y.; Berger, D. K.; Wu, Y.; Liu, Y.; Koh, W. X.; Parvathala, R.; Holmyard, D.; Schalek, R. L.; Shavit, N.; Chisholm, A. D.; Lichtman, J. W.; Samuel, A. D. T.; Zhen, M.
10.1101/2020.04.30.066209 — neuroscience — Posted on 2020-04-30
101 DNA Methylation Atlas of the Mouse Brain at Single-Cell Resolution
Liu, H.; Zhou, J.; Tian, W.; Luo, C.; Bartlett, A.; Aldridge, A.; Lucero, J.; Osteen, J. K.; Nery, J. R.; Chen, H.; Rivkin, A.; Castanon, R. G.; Clock, B.; Li, Y. E.; Hou, X.; Poirion, O. B.; Preissl, S.; O'Connor, C.; Boggeman, L.; Fitzpatrick, C.; Nunn, M.; Mukamel, E. A.; Zhang, Z.; Callaway, E. M.; Ren, B.; Dixon, J. R.; Behrens, M. M.; Ecker, J. R.
10.1101/2020.04.30.069377 — genomics — Posted on 2020-04-30
103 Transposable Elements activity and role in Meloidogyne incognita genome dynamic and adaptability
Kozlowski, D. K.; Hassanaly-Goulamhoussen, R.; Da-Rocha, M.; Bailly-Bechet, M.; Danchin, E. G.
10.1101/2020.04.30.069948 — evolutionary biology — Posted on 2020-04-30
108 Invasive freshwater snails form novel microbial symbioses
Bankers, L.; Dahan, D.; Neiman, M.; Adrian-Tucci, C.; Frost, C.; Hurst, G.; King, K.
10.1101/2020.04.29.069013 — evolutionary biology — Posted on 2020-04-30
111 Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA
Lee, J. Y.; Best, N.; McAuley, J. L.; Porter, J.; Seemann, T.; Schultz, M. B.; Sait, M.; Orlando, N.; Mercoulia, K.; Ballard, S. A.; Druce, J.; Tran, T.; Catton, M.; Pryor, M. J.; Cui, H. L.; Luttick, A.; McDonald, S.; Greenhalgh, A.; Kwong, J. C.; Sherry, N. L.; Graham, M.; Hoang, T.; Herisse, M.; Pidot, S. J.; Williamson, D. A.; Howden, B. P.; Monk, I. R.; Stinear, T. P.
10.1101/2020.04.28.067363 — microbiology — Posted on 2020-04-30
113 Investigating DNA methylation as a potential mediator between pigmentation genes, pigmentary traits and skin cancer
Bonilla, C.; Bertoni, B.; Min, J. L.; Hemani, G.; Genetics of DNA Methylation Consortium, ; Elliott, H. R.
10.1101/2020.04.29.060566 — genetics — Posted on 2020-04-30
115 HPC-REDItools: a Novel HPC-aware Tool for Improved Large Scale RNA-editing Analysis
Flati, T.; Gioiosa, S.; Spallanzani, N.; Tagliaferri, I.; Diroma, M. A.; Pesole, G.; Chillemi, G.; Picardi, E.; Castrignano, T.
10.1101/2020.04.30.069732 — bioinformatics — Posted on 2020-04-30
116 Programmatic access to bacterial regulatory networks with regutools
Chavez, J.; Barberena-Jonas, C.; Sotelo-Fonseca, J. E.; Alquicira-Hernandez, J.; Salgado, H.; Collado-Torres, L.; Reyes, A.
10.1101/2020.04.29.068551 — bioinformatics — Posted on 2020-04-30
117 Draft genome of the aquatic moss Fontinalis antipyretica (Fontinalaceae, Bryophyta)
Yu, J.; Li, L.; Wang, S.; Dong, S.; Chen, Z.; Patel, N.; Goffinet, B.; Liu, H.; Liu, Y.
10.1101/2020.04.29.069583 — genomics — Posted on 2020-04-30
124 Oculomotor inhibition precedes temporally expected auditory targets
Abeles, D.; Amit, R.; Tal-Perry, N.; Carrasco, M.; Yuval-Greenberg, S.
10.1101/2020.04.28.065839 — neuroscience — Posted on 2020-04-30
125 Fluorogenic probe for fast 3D whole-cell DNA-PAINT
Chung, K. K. H.; Zhang, Z.; Kidd, P.; Zhang, Y.; Williams, N. D.; Rollins, B.; Yang, Y.; Lin, C.; Baddeley, D.; Bewersdorf, J.
10.1101/2020.04.29.066886 — biophysics — Posted on 2020-04-30
126 Significant and conflicting correlation of IL-9 with Prevotella and Bacteroides in human colorectal cancer
Niccolai, E.; Russo, E.; Baldi, S.; Ricci, F.; Nannini, G.; Pedone, M.; Stingo, F. C.; Taddei, A.; Ringressi, M. N.; Bechi, P.; Mengoni, A.; Fani, R.; Bacci, G.; fagorzi, C.; Chiellini, C.; Prisco, D.; Ramazzotti, M.; Amedei, A.
10.1101/2020.04.28.066001 — immunology — Posted on 2020-04-30
130 Charting extracellular transcriptomes in The Human Biofluid RNA Atlas
Hulstaert, E.; Morlion, A.; Avila Cobos, F.; Verniers, K.; Nuytens, J.; Vanden Eynde, E.; Yigit, N.; Anckaert, J.; Geerts, A.; Hindryckx, P.; Jacques, P.; Brusselle, G.; Bracke, K. R.; Maes, T.; Malfait, T.; Derveaux, T.; Ninclaus, V.; Van Cauwenbergh, C.; Roelens, K.; Roets, E.; Hemelsoet, D.; Tilleman, K.; Brochez, L.; Kuersten, S.; Simon, L.; Karg, S.; Kautzky-Willers, A.; Leutner, M.; Nöhammer, C.; Slaby, O.; Willinge Prins, R.; Koster, J.; Lefever, S.; Schroth, G. P.; Vandesompele, J.; Mestdagh, P.
10.1101/823369 — genomics — Posted on 2020-04-30
131 Integrative transcriptomic analysis of SLE reveals IFN-driven cross-talk between immune cells
Panwar, B.; Schmiedel, B. J.; Liang, S.; White, B.; Rodriquez, E.; Kalunian, K.; McKnight, A. J.; Soloff, R.; Seumois, G.; Vijayanand, P.; Ay, F.
10.1101/2020.04.27.065227 — genomics — Posted on 2020-04-30
132 Proteasome activator PA200 maintains stability of histone marks during transcription and aging
Jiang, T.; Ma, S.; Han, X.; Luo, Z.; Zhu, Q.; Chiba, T.; Xie, W.; Chen, S.; Lin, K.; Qiu, X.
10.1101/2020.04.28.067132 — cell biology — Posted on 2020-04-30
136 Gene duplication drives genome expansion in Thaumarchaeota
Sheridan, P. O.; Raguideau, S.; Quince, C.; Thames Consortium, ; Williams, T. A.; Gubry-Rangin, C.
10.1101/2020.04.28.065540 — evolutionary biology — Posted on 2020-04-30
140 A footptrint of plant eco-geographic adaptation on the composition of the barley rhizosphere bacterial microbiota
Alegria Terrazas, R.; Balbirnie-Cumming, K.; Morris, J.; Hedley, P.; Russell, J.; Paterson, E.; Baggs, E.; Fridman, E.; Bulgarelli, D.
10.1101/2020.02.11.944140 — plant biology — Posted on 2020-04-30
146 Prochlorococcus rely on microbial interactions rather than on chlorotic resting stages to survive long-term nutrient starvation
Roth-Rosenberg, D.; Aharonovich, D.; Luzzatto-Knaan, T.; Vogts, A.; Zoccarato, L.; Eigemann, F.; Nago, N.; Grossart, H.-P.; Voss, M.; Sher, D. J.
10.1101/657627 — microbiology — Posted on 2020-04-30
152 Marine foams represent compressed sea-surface microlayer with distinctive bacterial communities
Rahlff, J.; Stolle, C.; Giebel, H.-A.; Mustaffa, N. I. H.; Wurl, O.; Herlemann, D.
10.1101/820696 — microbiology — Posted on 2020-04-30
153 Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation.
King, H. W.; Orban, N.; Riches, J. C.; Clear, A. J.; Warnes, G.; Teichmann, S. A.; James, L. K.
10.1101/2020.04.28.054775 — immunology — Posted on 2020-04-30
156 Systemic paralogy and function of retinal determination network homologs in arachnids
Gainett, G.; Ballesteros, J. A.; Kanzler, C. R.; Zehms, J. T.; Zern, J. M.; Aharon, S.; Gavish-Regev, E.; Sharma, P. P.
10.1101/2020.04.28.067199 — developmental biology — Posted on 2020-04-30
159 Dragonfly Inspired Smart Soft Robot
Kumar, V.; Ko, U.; Zhou, Y.; Hoque, J.; Arya, G.; Varghese, S.
10.1101/2020.04.28.067033 — bioengineering — Posted on 2020-04-30
161 Meta-reinforcement learning in a thalamo-orbitofrontal circuit
Namboodiri, V.; Hobbs, T.; Trujillo-Pisanty, I.; Simon, R.; Stuber, G.
10.1101/2020.04.28.066878 — neuroscience — Posted on 2020-04-30
162 Inferring the infant pain experience: a translational fMRI-based signature approach
Duff, E. P.; Moultrie, F.; Goksan, S.; van der Vaart, M.; Abos, A.; Baxter, L.; Fitzgibbon, S. P.; Wager, T. D.; Slater, R.
10.1101/2020.04.01.998864 — neuroscience — Posted on 2020-04-30
163 Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons
Kastli, R.; Vighagen, R.; van der Bourg, A.; Argunsah, A. O.; Iqbal, A.; Voigt, F. F.; Kirschenbaum, D.; Aguzzi, A.; Helmchen, F.; Karayannis, T.
10.1101/2020.04.28.065680 — neuroscience — Posted on 2020-04-30
167 Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation
Zhang, Y.; Jiang, C.; Trudeau, S. J.; Narita, Y.; Zhao, B.; Teng, M.; Guo, R.; Gewurz, B.
10.1101/2020.04.28.067371 — microbiology — Posted on 2020-04-30
169 Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection.
Ram-Mohan, N.; Thair, S.; Litzenburger, U.; Cogill, S. B.; Andini, N.; Yang, X.; Chang, H.; Yang, S. S.
10.1101/2020.04.28.066829 — immunology — Posted on 2020-04-30
172 DCP, First Generation PET Radiotracer for Diagnosis of Radiation Resistant Head and Neck Cancer
Chen, X.; Kumar Solingapuram Sai, K.; Li, Z.; Zhu, C.; Shukla, K.; Forshaw, T. E.; Wu, H.; Vance, S.; Madonna, M.; Dewhirst, M. W.; Tsang, A. W.; Poole, L. B.; Ramanujam, N.; King, S. B.; Furdui, C. M.
10.1101/2020.04.28.063537 — cancer biology — Posted on 2020-04-30
173 The TAT Protein Transduction Domain as an Intra-articular Drug-Delivery Technology
Mailhiot, S. E.; Thompson, M. A.; Eguchi, A.; Dinkel, S.; Lotz, M. K.; Dowdy, S. F.; June, R. K.
10.1101/2020.04.28.066902 — bioengineering — Posted on 2020-04-30
174 Biochemically diverse CRISPR-Cas9 orthologs
Gasiunas, G.; Young, J. K.; Karvelis, T.; Kazlauskas, D.; Urbaitis, T.; Jasnauskaite, M.; Grusyte, M.; Paulraj, S.; Wang, P.-H.; Hou, Z.; Dooley, S. K.; Cigan, M.; Alarcon, C.; Chilcoat, N. D.; Bigelyte, G.; Curcuru, J. L.; Mabuchi, M.; Sun, Z.; Fuchs, R. T.; Schildkraut, E.; Weigele, P. R.; Jack, W. E.; Robb, G. B.; Venclovas, C.; Siksnys, V.
10.1101/2020.04.29.066654 — biochemistry — Posted on 2020-04-30
178 Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia
Zhao, X.; Lorent, K.; Escobar-Zarate, D.; Rajagopalan, R.; Loomes, K.; Gillespie, K.; Mesaros, C.; Estrada, M.; Blair, I.; Winkler, J.; Spinner, N.; Devoto, M.; Pack, M.
10.1101/821967 — pathology — Posted on 2020-04-30
179 Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia
Zhao, X.; Lorent, K.; Escobar-Zarate, D.; Rajagopalan, R.; Loomes, K.; Gillespie, K.; Mesaros, C.; Estrada, M.; Blair, I.; Winkler, J.; Spinner, N.; Devoto, M.; Pack, M.
10.1101/821967 — pathology — Posted on 2020-04-30
181 Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
Heaton, G. R.; Landeck, N.; Mamais, A.; Nalls, M. A.; Nixon-Abell, J.; Kumaran, R.; Beilina, A.; Pelligrini, L.; Li, Y.; Harvey, K.; Cookson, M. R.
10.1101/2020.04.28.053660 — molecular biology — Posted on 2020-04-30
182 Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
Ait-Ammar, A.; Bellefroid, M.; Daouad, F.; Martinelli, V.; Van Assche, J.; Wallet, C.; De Rovere, M.; Fahrenkrog, B.; Schwartz, C.; Van Lint, C.; Gautier, V.; ROHR, O.
10.1101/2020.04.28.066274 — molecular biology — Posted on 2020-04-30
183 Infection with CagA+ Helicobacter pylori induces epithelial to mesenchymal transition in human cholangiocytes
Thanaphongdecha, P.; Speigh, S.; Tanno, W. I.; Mann, V. H.; Chamgramol, Y.; Pairojkul, C.; Suttiprapa, S.; Sripa, B.; Brindley, P. J.
10.1101/2020.04.28.066324 — molecular biology — Posted on 2020-04-30
184 Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.
Hannon, E.; Dempster, E.; Mansell, G.; Burrage, J.; Bass, N.; Bohlken, M.; Corvin, A.; Curtis, C.; Dempster, D.; Di Forta, M.; Dinan, T.; Donohoe, G.; Gaughran, F.; Gill, M.; Gillespie, A.; Gunasinghe, C.; Hulshoff, H.; Hultman, C.; Johansson, V.; Kahn, R.; Kaprio, J.; Kenis, G.; Kowalec, K.; MacCabe, J.; McDonald, C.; McQuillin, A.; Morris, D.; Murphy, K.; Mustard, C.; Nenadic, I.; O'Donovan, M.; Quattrone, D.; Richards, A.; Rutten, B.; St. Clair, D.; Therman, S.; Toulopoulou, T.; Van Os, J.; Waddington, J.; Wellcome Trust Case Control Consortium 2, ; CRESTAR Consortium, ; Sullivan, P.; Bre
10.1101/2020.04.05.026211 — genomics — Posted on 2020-04-30
185 Diachronic monitoring of snow leopards at Sarychat-Ertash State Reserve (Kyrgyzstan) through scat genotyping: a pilot study
Rode, J.; Pelletier, A.; Fumey, J.; Rode, S.; Cabanat, A.-L.; Ouvrard, A.; Chaix, B.; White, B.; Harnden, M.; Thi Xuan, N.; Vereshagin, A.; Casane, D.
10.1101/835025 — genetics — Posted on 2020-04-30
187 The network structure and eco-evolutionary dynamics of CRISPR-induced immune diversification
Pilosof, S.; Alcala-Corona, S. A.; Wang, T.; Kim, T.; Maslov, S.; Whitaker, R. J.; Pascual, M.
10.1101/850800 — evolutionary biology — Posted on 2020-04-30
188 The network structure and eco-evolutionary dynamics of CRISPR-induced immune diversification
Pilosof, S.; Alcala-Corona, S. A.; Wang, T.; Kim, T.; Maslov, S.; Whitaker, R. J.; Pascual, M.
10.1101/850800 — evolutionary biology — Posted on 2020-04-30
189 The Past, Present and Future of Elephant Landscapes in Asia
de Silva, S.; Wu, T.; Thieme, A.; Johnson, J.; Nyhus, P.; Wadey, J.; Vu, T.; Mossbrucker, A.; Neang, T.; Chen, B. S.; Songer, M.; Leimgruber, P.
10.1101/2020.04.28.066548 — ecology — Posted on 2020-04-30
191 A Mechanical Model of Early Somite Segmentation
Adhyapok, P.; Piatkowska, A. M.; Norman, M. J.; Clendenon, S. G.; Stern, C. D.; Glazier, J. A.; Belmonte, J. M.
10.1101/804203 — developmental biology — Posted on 2020-04-30
193 Suppressing chemoresistance in lung cancer via dynamic phenotypic switching and intermittent therapy
Nam, A.; Mohanty, A.; Bhattacharya, S.; Kotnala, S.; Achuthan, S.; Hari, K.; Nathan, A.; Rangarajan, G.; Massarelli, E.; Levine, H.; Jolly, M. K.; Kulkarni, P.; Salgia, R.
10.1101/2020.04.06.028472 — cancer biology — Posted on 2020-04-30
194 Suppressing chemoresistance in lung cancer via dynamic phenotypic switching and intermittent therapy
Nam, A.; Mohanty, A.; Bhattacharya, S.; Kotnala, S.; Achuthan, S.; Hari, K.; Nathan, A.; Rangarajan, G.; Massarelli, E.; Levine, H.; Jolly, M. K.; Kulkarni, P.; Salgia, R.
10.1101/2020.04.06.028472 — cancer biology — Posted on 2020-04-30
195 Classic oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer
Patel, A. S.; Yoo, S.; Kong, R.; Sato, T.; Sinha, A.; Bao, L.; Fridrikh, M.; Emoto, K.; Nudelman, G.; Powell, C. A.; Beasley, M. B.; Zhu, J.; Watanabe, H.
10.1101/852939 — cancer biology — Posted on 2020-04-30
196 Classic oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer
Patel, A. S.; Yoo, S.; Kong, R.; Sato, T.; Sinha, A.; Bao, L.; Fridrikh, M.; Emoto, K.; Nudelman, G.; Powell, C. A.; Beasley, M. B.; Zhu, J.; Watanabe, H.
10.1101/852939 — cancer biology — Posted on 2020-04-30
197 Single-cell copy number calling and event history reconstruction
Kuipers, J.; Tuncel, M. A.; Ferreira, P.; Jahn, K.; Beerenwinkel, N.
10.1101/2020.04.28.065755 — cancer biology — Posted on 2020-04-30
200 Establishment of a stable zg6pdM118-144 transgenic zebrafish model of glucose-6-phosphate dehydrogenase deficiency
Zhou, Y.-H.; Ren, P.-P.; Xia, H.-X.; Tuo, Y.-Y.; Song, J.; Shang, L.-J.; Jin, J.; He, Z.-X.; Shu, L.
10.1101/2020.04.28.066779 — zoology — Posted on 2020-04-30
206 Evaluation of the potassium channel tracer 3F4AP in rhesus macaques
Guehl, N.; Ramos-Torres, K.; Linnman, C.; Moon, S.-H.; Dhaynaut, M.; Wilks, M.; Han, P.; Ma, C.; Neelamegam, R.; Zhou, Y.-P.; Popko, B.; Correia, J. A.; Reich, D. S.; El Fakhri, G.; Herscovitch, P.; Normandin, M.; Brugarolas, P.
10.1101/2020.04.28.065094 — neuroscience — Posted on 2020-04-30
207 Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice
Maldonado-Devincci, A. M.; Makdisi, J. G.; Hill, A. M.; Waters, R. C.; Hall, N. I.; Jones, M. C.; Shobande, M.; Kumari, A.
10.1101/2020.04.28.066472 — neuroscience — Posted on 2020-04-30
208 Functional and diffusion MRI reveal the functional and structural basis of infants' noxious-evoked brain activity
Baxter, L.; Moultrie, F.; Fitzgibbon, S.; Aspbury, M.; Mansfield, R.; Bastiani, M.; Rogers, R.; Jbabdi, S.; Duff, E.; Slater, R.
10.1101/2020.04.28.065730 — neuroscience — Posted on 2020-04-30
209 Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency
Davis, B. A.; David, F.; O'Regan, C.; Adam, M.; Harwood, A.; Crunelli, V.; Isles, A.
10.1101/257626 — neuroscience — Posted on 2020-04-30
210 Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesion of midbrain dopaminergic neurons
Radlicka, A.; Kaminska, K.; Borczyk, M.; Piechota, M.; Korostynski, M.; Pera, J.; Lorenc-Koci, E.; Rodriguez Parkitna, J.
10.1101/2020.04.28.063347 — neuroscience — Posted on 2020-04-30
213 High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica
Righetto, R. D.; Anton, L.; Adaixo, R.; Jakob, R. P.; Zivanov, J.; Mahi, M.-A.; Ringler, P.; Schwede, T.; Maier, T.; Stahlberg, H.
10.1101/2020.04.28.065599 — molecular biology — Posted on 2020-04-30
215 Novel structural components generate distinct type VI secretion system anchoring modes
Bernal, P.; Furniss, R. C. D.; Fecht, S.; Leung, R. C. Y.; Spiga, L.; Mavridou, D. A. I.; Filloux, A.
10.1101/2020.04.29.069310 — microbiology — Posted on 2020-04-30
217 Passenger-surface microbiome interactions in the subway of Mexico City
Vargas-Robles, D.; Gonzalez-Cedillo, C.; Hernandez, A. M.; Alcaraz, L. D.; Peimbert, M.
10.1101/2020.04.28.067041 — microbiology — Posted on 2020-04-30
218 Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy
Lyons, N.; Softley, I.; Balfour, A.; Williamson, C.; O'Brien, H.; Shetty, A. C.; Bruno, V. M.; Diezmann, S.
10.1101/693226 — microbiology — Posted on 2020-04-30
219 Dynamics of the Bacillus subtilis Min system
Feddersen, H.; Wuerthner, L.; Frey, E.; Bramkamp, M.
10.1101/2020.04.29.068676 — microbiology — Posted on 2020-04-30
222 A decade of epigenetic change in aging twins: genetic and environmental contributions to longitudinal DNA methylation
Reynolds, C. A.; Tan, Q.; Munoz, E.; Jylhava, J.; Hjelmborg, J.; Christiansen, L.; Hagg, S.; Pedersen, N. L.
10.1101/778555 — genetics — Posted on 2020-04-30
228 Glycocalyx-Mediated Vascular Dissemination of Circulating Tumor Cells
Offeddu, G.; Hajal, C.; Foley, C.; Wan, Z.; Ibrahim, L.; Coughlin, M.; Kamm, R.
10.1101/2020.04.28.066746 — cancer biology — Posted on 2020-04-30
229 Unequivocal mapping of molecular ether lipid species by LC-MS/MS in plasmalogen-deficient mice
Koch, J.; Lackner, K.; Wohlfarter, Y.; Sailer, S.; Zschocke, J.; Werner, E. R.; Watschinger, K.; Keller, M. A.
10.1101/2020.04.29.066530 — biochemistry — Posted on 2020-04-30
230 The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel-Lindau tumor suppressor
Falconieri, A.; Minervini, G.; Bortolotto, R.; Piovesan, D.; Lopreiato, R.; Sartori, G.; Pennuto, M.; Tosatto, S. C. E.
10.1101/2020.04.28.066084 — biochemistry — Posted on 2020-04-30
231 Single-Cell Transcriptomic Analysis of mIHC Images via Antigen Mapping
Govek, K. W.; Troisi, E. C.; Miao, Z.; Woodhouse, S.; Camara, P. G.
10.1101/672501 — bioinformatics — Posted on 2020-04-30
236 Chronostratigraphy of Jerzmanowician.New data from Koziarnia Cave, Poland.
Kot, M. A.; Krajcarz, M. T.; Moskal-del Hoyo, M.; Gryczewska, N.; Wojenka, M.; Pyzewicz, K.; Sinet-Mathiot, V.; Diakowski, M.; Fedorowicz, S.; Gasiorowski, M.; Marciszak, A.; Mackiewicz, P.
10.1101/2020.04.29.067967 — paleontology — Posted on 2020-04-29
239 SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.
Mycroft-West, C.; Su, D.; Li, Y.; Guimond, S.; Rudd, T.; Elli, S.; Miller, G.; Nunes, Q.; Procter, P.; Bisio, A.; Forsyth, N.; Turnbull, J.; Guerrini, M.; Fernig, D.; Yates, E.; Lima, M.; Skidmore, M.
10.1101/2020.04.29.068486 — biochemistry — Posted on 2020-04-29
240 Activity profiling of SARS-CoV-2-PLpro protease provides structural framework for anti-COVID-19 drug design
Rut, W.; Zmudzinski, M.; Lyu, Z.; Nayak, D.; Snipas, S. J.; Bekes, M.; Huang, T. T.; Olsen, S. K.; Drag, M.
10.1101/2020.04.29.068890 — biochemistry — Posted on 2020-04-29
241 Pigmentation loci as markers for genome editing in the Chagas disease vector Rhodnius prolixus
Berni, M.; Bressan, D.; Simao, Y.; Julio, A.; Oliveira, P. L.; Pane, A.; Araujo, H. M.
10.1101/2020.04.29.067934 — genetics — Posted on 2020-04-29
243 Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.
Mycroft-West, C.; Su, D.; Li, Y.; Guimond, S.; Rudd, T.; Elli, S.; Miller, G.; Nunes, Q.; Procter, P.; Bisio, A.; Forsyth, N.; Turnbull, J.; Guerrini, M.; Fernig, D.; Yates, E.; Lima, M.; Skidmore, M.
10.1101/2020.04.29.068767 — biochemistry — Posted on 2020-04-29
247 DNA repair-based classification of melanoma cell lines reveals an effect of mutations in BRAF and NRAS driver genes on DNA repair capacity
Sauvaigo, S.; Benkhiat, M.; Braisaz, F.; Libert, S.; Girard, J.; Mouret, S.; de Fraipont, F.; Aspord, C.; Bouquet, F.; Leccia, M.-T.
10.1101/2020.04.29.067900 — cancer biology — Posted on 2020-04-29
249 Toward the pathogenicity of the SLC26A4 p.C565Y variant using a genetically driven mouse model
Hu, C.-J.; Lu, Y.-C.; Yang, T.-H.; Chan, Y.-H.; Tsai, C.-Y.; Yu, I.-S.; Lin, S.-W.; Liu, T.-C.; Cheng, Y.-F.; Wu, C.-C.; Hsu, C.-J.
10.1101/2020.04.29.067918 — genetics — Posted on 2020-04-29
250 Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation
Bernabeu, M. O.; Kory, J.; Grogan, J. A.; Markelc, B.; Beardo, A.; d'Avezac, M.; Enjalbert, R.; Kaeppler, J.; Daly, N.; Hetherington, J.; Krueger, T.; Maini, P. K.; Pitt-Francis, J. M.; Muschel, R. J.; Alarcon, T.; Byrne, H. M.
10.1101/640060 — cancer biology — Posted on 2020-04-29
254 Population genomic evidence of a Southeast Asian origin of Plasmodium vivax
Daron, J.; Boissiere, A.; Ngoubangoye, B.; Boundenga, L.; Houze, S.; Arnathau, C.; Sidobre, C.; Trape, J.-F.; Durant, P.; Renaud, F.; Fontaine, M.; Prugnolle, F.; Rougeron, V.
10.1101/2020.04.29.067439 — evolutionary biology — Posted on 2020-04-29
255 Structural analysis of SARS-CoV-2 and predictions of the human interactome
Vandelli, A.; Monti, M.; Milanetti, E.; Rupert, J.; Zacco, E.; Bechara, E.; Delli Ponti, R.; Tartaglia, G. G.
10.1101/2020.03.28.013789 — bioinformatics — Posted on 2020-04-29
257 Introductions and early spread of SARS-CoV-2 in France
Gambaro, F.; Baidaliuk, A.; Behillil, S.; Donati, F.; Albert, M.; Alexandru, A.; Vanpeene, M.; Bizard, M.; Brisebarre, A.; Barbet, M.; Derrar, F.; van der Werf, S.; Enouf, V.; Simon-Loriere, E.
10.1101/2020.04.24.059576 — genomics — Posted on 2020-04-29
262 Effect of Testosterone on Antler Growth in Male Sambar Deer (Rusaunicolor unicolor) in Horton Plains National Park, Sri Lanka
Weerasekera, D. S.; Rathnasekera, N. L.; Nanayakkara, D. K. K.; Herath, H. M. S. S.; Perera, S. J.; Ranawana, K. B.
10.1101/740936 — zoology — Posted on 2020-04-29
263 Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a poikilothermic mammal
Oiwa, Y.; Oka, K.; Yasui, H.; Higashikawa, K.; Bono, H.; Kawamura, Y.; Miyawaki, S.; Watarai, A.; Kikusui, T.; Shimizu, A.; Okano, H.; Kuge, Y.; Kimura, K.; Okamatsu-Ogura, Y.; Miura, K.
10.1101/2020.04.28.062737 — zoology — Posted on 2020-04-29
264 Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India
BEGUM, F.; MUKHERJEE, D.; THAKRIKI, D.; DAS, S.; TRIPATHI, P. P.; BANERJEE, A. K.; RAY, U.
10.1101/2020.04.28.066985 — molecular biology — Posted on 2020-04-29
273 Lisen&Curate: A platform to facilitate knowledge tools for curation of regulation of transcription initiation in bacteria
Mendez-Cruz, C.-F.; Diaz-Rodriguez, M.; Guadarrama-Garcia, F.; Lithgow-Serrano, O. W.; Gama-Castro, S.; Solano-Lira, H.; Rinaldi, F.; Collado-Vides, J.
10.1101/2020.04.28.065243 — bioinformatics — Posted on 2020-04-29
274 Predicting Antimicrobial Resistance Using Conserved Genes
Nguyen, M.; Olson, R.; Shukla, M.; VanOeffelen, M.; Davis, J. J.
10.1101/2020.04.29.068254 — bioinformatics — Posted on 2020-04-29
277 Robust gene expression-based classification of cancers without normalization
Jiang, A.; Hilton, L. K.; Tang, J.; Rushton, C. K.; Grande, B. M.; Scott, D. W.; Morin, R. D.
10.1101/2020.04.28.051953 — bioinformatics — Posted on 2020-04-29
281 BCL-XL is essential for the protection from secondary anemia caused by radiation-induced fatal kidney damage
Brinkmann, K.; Waring, P.; Glaser, S.; Wimmer, V.; Nhu, D.; Whitehead, L.; Delbridge, A. R.; Lessene, G.; Herold, M.; Kelly, G. L.; Grabow, S.; Strasser, A.
10.1101/2020.04.28.055665 — pharmacology and toxicology — Posted on 2020-04-29
283 The hepatic compensatory response to elevated systemic sulfide impairs medium chain fat oxidation and promotes diabetes
Carter, R. N.; Gibbins, M. T. G.; Barrios-Llerena, M. E.; Wilkie, S.; Freddolino, P.; Libiad, M.; Vitvitsky, V.; Emerson, B.; LeBihan, T.; Brice, M.; Su, H.; Denham, S.; Homer, N. Z. M.; Mc Fadden, C.; Tailleux, A.; Faresse, N.; Sulpice, T.; Briand, F.; Gillingwater, T.; Ahn, K. H.; Singha, S.; McMaster, C.; Hartley, R. C.; Staels, B.; Gray, G. A.; Finch, A.; Selman, C.; Banerjee, R.; Morton, N. M.
10.1101/2020.04.27.064287 — physiology — Posted on 2020-04-29
284 Safety, pharmacokinetics, and liver-stage Plasmodium cynomolgi effect of high-dose ivermectin and chloroquine in Rhesus Macaques
Vanachayangkul, P.; Im-Erbsin, R.; Tungtaeng, A.; Kodchakorn, C.; Roth, A.; Adams, J. H.; Chaisatit, C.; Saingam, P.; Sciotti, R. J.; Reichard, G. A.; Nolan, C. K.; Pybus, B. S.; Black, C. C.; Lugo, L. A.; Wegner, M. D.; Smith, P. l.; Wojnarski, M.; Vesely, B. A.; Kobylinski, K. C.
10.1101/2020.04.27.065409 — pharmacology and toxicology — Posted on 2020-04-29
285 Criterion Validity and Relationships between Alternative Hierarchical Dimensional Models of General and Specific Psychopathology
Moore, T. M.; Kaczkurkin, A. N.; Durham, E. L.; Jeong, H. J.; McDowell, M. G.; Dupont, R. M.; Applegate, B.; Tackett, J. L.; Cardenas-Iniguez, C.; Kardan, O.; Akcelik, G.; Stier, A. J.; Rosenberg, M. D.; Hedeker, D.; Berman, M. G.; Lahey, B. B.
10.1101/2020.04.27.064303 — neuroscience — Posted on 2020-04-29
286 Induction of Alzheimer's disease pathology by early-life stress
Tanaka, T.; Hirai, S.; Hosokawa, M.; Saito, T.; Sakuma, H.; Saido, T.; Hasegawa, M.; Okado, H.
10.1101/2020.04.27.062729 — neuroscience — Posted on 2020-04-29
289 Testosterone induces a female ornament followed by enhanced territoriality in a tropical songbird
Boersma, J.; Enbody, E. D.; Jones, J. A.; Nason, D.; Lopez-Contreras, E.; Karubian, J.; Schwabl, H.
10.1101/2020.04.27.065011 — animal behavior and cognition — Posted on 2020-04-29
290 Geometrical model explains multiple preferred escape trajectories of fish
Kawabata, Y.; Akada, H.; Shimatani, K.-i.; Nishihara, G. N.; Kimura, H.; Nishiumi, N.; Domenici, P.
10.1101/2020.04.27.049833 — animal behavior and cognition — Posted on 2020-04-29
291 DNA damage independent inhibition of NF-κB transcription by anthracyclines
Chora, A.; Pedroso, D.; Pejanovic, N.; Kyriakou, E.; Colaco, H.; Gozzelino, R.; Barros, A.; Willmann, K.; Velho, T.; Moita, C.; Santos, I.; Carvalho, S.; Martins, F.; Ferreira, J.; Almeida, S.; Benes, V.; Anrather, J.; Soares, M.; Geerlof, A.; Neefjes, J.; Sattler, M.; Messias, A.; Neves-Costa, A.; Moita, L. F.
10.1101/2020.04.27.065003 — immunology — Posted on 2020-04-29
292 Efficient gene-environment interaction tests for large biobank-scale sequencing studies
Wang, X.; Lim, E.; Liu, C.-T.; Sung, Y. J.; Rao, D. C.; Morrison, A. C.; Boerwinkle, E.; Manning, A. K.; Chen, H.
10.1101/2020.04.28.067173 — genetics — Posted on 2020-04-29
296 Genetic determinism of spontaneous masculinisation in XX female rainbow trout: new insights using medium throughput genotyping and whole-genome sequencing
Fraslin, C.; Phocas, F.; Bestin, A.; Charles, M.; Bernard, M.; Krieg, F.; Dechamp, N.; Ciobotaru, C.; Hoze, C.; Petitprez, F.; Milhes, M.; Lluch, J.; Bouchez, O.; Poncet, C.; Hocde, P.; Haffray, P.; Guiguen, Y.; Quillet, E.
10.1101/2020.04.28.057240 — genomics — Posted on 2020-04-29
298 ArchR: An integrative and scalable software package for single-cell chromatin accessibility analysis
Granja, J. M.; Corces, M. R.; Pierce, S. E.; Bagdatli, S. T.; Choudhry, H.; Chang, H.; Greenleaf, W.
10.1101/2020.04.28.066498 — genomics — Posted on 2020-04-29
299 SNP genotyping and population analysis of five indigenous Kazakh sheep breeds
Pozharskiy, A.; Khamzina, A.; Gritsenko, D.; Khamzina, Z.; Kassymbekova, S.; Karimov, N.; Karymsakov, T.; Tlevlesov, N.
10.1101/2020.04.28.065797 — genetics — Posted on 2020-04-29
302 Placental microRNA Expression Associates with Birthweight through Control of Adipokines: Results from Two Independent Cohorts
Kennedy, E. M.; Hermetz, K.; Burt, A.; Everson, T. M.; Deyssenroth, M.; Hao, K.; Chen, J.; Karagas, M. R.; Pei, D.; Koestler, D. C.; Marsit, C. J.
10.1101/2020.04.28.067025 — genetics — Posted on 2020-04-29
303 LDpred2: better, faster, stronger
Prive, F.; Arbel, J.; Vilhjalmsson, B. J.
10.1101/2020.04.28.066720 — genetics — Posted on 2020-04-29
308 Selection and local adaptation in capuchin monkeys revealed through fluorescence-activated cell sorting of feces (fecalFACS)
Orkin, J. D.; Montague, M. J.; Tejada-Martinez, D.; de Manuel, M.; del Campo, J.; Di Fiore, A.; Fontsere, C.; Hodgson, J. A.; Janiak, M. C.; Kuderna, L. F. K.; Lizano, E.; Niimura, Y.; Perry, G. H.; Tang, J.; Warren, W. C.; de Magalhaes, J. P.; Kawamura, S.; Marques-Bonet, T.; Krawetz, R.; Melin, A. D.
10.1101/366112 — genomics — Posted on 2020-04-29
311 Impact of N-terminally substituted glucagon family receptor agonists on signal bias, trafficking and downstream responses
Jones, B.; McGlone, E. R.; Fang, Z.; Pickford, P.; Correa, I. R.; Kumar, S.; Görlitz, F.; Dunsby, C.; French, P. M.; Rutter, G. A.; Tan, T. M.; Tomas, A.; Bloom, S. R.
10.1101/2020.04.26.062372 — pharmacology and toxicology — Posted on 2020-04-29
312 Cell-free DNA Tissues-of-Origin Profiling to Predict Graft versus Host Disease and Detect Infection after Hematopoietic Cell Transplantation
Cheng, A. P.; Cheng, M. P.; Lenz, J. S.; Chen, K.; Burnham, P.; Timblin, K. M.; Orejas, J. L.; Silverman, E.; Marty, F. M.; Ritz, J.; De Vlaminck, I.
10.1101/2020.04.25.061580 — genomics — Posted on 2020-04-29
314 Physical properties and actin organization in embryonic stem cells depend on differentiation stage
Hvid, K. G.; Barooji, Y. F.; Petitjean, I. I.; Brickman, J. M.; Oddershede, L. B.; Bendix, P. M.
10.1101/2020.04.27.063891 — biophysics — Posted on 2020-04-29
315 The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.
Mycroft-West, C. J.; Su, D.; Elli, S.; Li, Y.; Guimond, S. E.; Miller, G. J.; Turnbull, J. E.; Yates, E. A.; Guerrini, M.; Fernig, D. G.; Andrade de Lima, M.; Skidmore, M. A.
10.1101/2020.02.29.971093 — biochemistry — Posted on 2020-04-29
316 Conformational stability and dynamics in crystals recapitulate protein behaviour in solution
Sala, B. M.; Le Marchand, T.; Pintacuda, G.; Camilloni, C.; Natalello, A.; Ricagno, S.
10.1101/2020.04.27.063909 — biochemistry — Posted on 2020-04-29
317 Tetramerisation of the CRISPR ring nuclease Csx3 facilitates cyclic oligoadenylate cleavage
Graham, S.; Grüschow, S.; Gloster, T. M.; McQuarrie, S.; White, M. F.; Athukoralage, J. S.
10.1101/2020.04.28.066118 — biochemistry — Posted on 2020-04-29
318 Volatile allosteric antagonists of mosquito odorant receptors inhibit normal odor-dependent behaviors
Kythreoti, G.; Sdralia, N.; Tsitoura, P.; Papachristos, D. P.; Michaelakis, A.; Karras, V.; Ruel, D. M.; Yakir, E.; Bohbot, J. D.; Schulz, S.; Iatrou, K.
10.1101/2020.04.26.062919 — neuroscience — Posted on 2020-04-29
319 Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response
Pierre, P.; Mendes, A.; Gigan, J. P.; Rodriguez Rodrigues, C.; Choteau, S. A.; Sanseau, D.; Barros, D.; Almeida, C.; Camosseto, V.; Chasson, L.; Paton, A. W.; Paton, J. C.; Argüello, R. J.; Lennon-Dumenil, A.-M.; Gatti, E.
10.1101/2020.04.27.063438 — immunology — Posted on 2020-04-29
325 The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.
Mycroft-West, C. J.; Su, D.; Elli, S.; Li, Y.; Guimond, S. E.; Miller, G. J.; Turnbull, J. E.; Yates, E. A.; Guerrini, M.; Fernig, D. G.; Andrade de Lima, M.; Skidmore, M. A.
10.1101/2020.02.29.971093 — biochemistry — Posted on 2020-04-29
328 Engineering Highly Homogenous Tetravalent IgGs with Enhanced Sperm Agglutination Potency
Shrestha, B.; Schaefer, A.; Chavez, E. C.; Kopp, A. J.; Jacobs, T. M.; Moench, T. R.; Lai, S.
10.1101/2020.04.27.064865 — molecular biology — Posted on 2020-04-29
330 Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent MS risk
Ong, L. T. C.; Schibeci, S. D.; Fewings, N. L.; Booth, D. R.; Parnell, G. P.
10.1101/2020.04.27.062075 — genetics — Posted on 2020-04-29
332 Asynchrony between virus diversity and antibody selection limits influenza virus evolution
Morris, D. H.; Petrova, V. N.; Rossine, F. W.; Parker, E.; Grenfell, B. T.; Neher, R.; Levin, S. A.; Russell, C. A.
10.1101/2020.04.27.064915 — evolutionary biology — Posted on 2020-04-29
334 Taxonomic, temporal, and spatial variation in the dynamics of High-Arctic arthropod populations
Høye, T. T.; Loboda, S.; Koltz, A. M.; Gillespie, M. A. K.; Bowden, J. J.; Schmidt, N. M.
10.1101/2020.04.27.052795 — ecology — Posted on 2020-04-29
335 HRIBO - High-throughput analysis of bacterial ribosome profiling data
Gelhausen, R.; Heyl, F.; Svensson, S. L.; Froschauer, K.; Hadjeras, L.; Sharma, C. M.; Eggenhofer, F.; Backofen, R.
10.1101/2020.04.27.046219 — bioinformatics — Posted on 2020-04-29
338 Conserved Molecular Function and Regulatory Subfunctionalization of the LORELEI Gene Family in Brassicaceae
Noble, J. A.; Liu, M.-C. J.; DeFalco, T. A.; Stegmann, M.; McNamara, K.; Sullivan, B.; Dinh, K. K.; Khuu, N.; Hancock, S.; Shiu, S.-H.; Zipfel, C.; Beilstein, M. A.; Cheung, A. Y.; Palanivelu, R.
10.1101/2020.04.27.062893 — plant biology — Posted on 2020-04-29
341 Dopamine modulates dynamic decision-making during foraging
Le Heron, C.; Kolling, N.; Plant, O.; Kienast, A.; Janska, R.; Ang, Y. S.; Fallon, S.; Husain, M.; Apps, M.
10.1101/709857 — neuroscience — Posted on 2020-04-29
342 Topologically correct synthetic reconstruction of pathogen social behavior found in deep tissue sites
Clark, S. A.; Thibault, D.; Shull, L. M.; Davis, K. M.; Aunins, E.; van Opijnen, T.; Isberg, R. R.
10.1101/2020.04.27.065144 — microbiology — Posted on 2020-04-29
343 Subtelomeric regions and a repeat-rich chromosome harbor multicopy effector gene clusters with variable conservation in multiple plant pathogenic Colletotrichum species
Gan, P.; Hiroyama, R.; Tsushima, A.; Masuda, S.; Shibata, A.; Ueno, A.; Kumakura, N.; Narusaka, M.; Hoat, T. X.; Narusaka, Y.; Takano, Y.; Shirasu, K.
10.1101/2020.04.28.061093 — genomics — Posted on 2020-04-29
344 Integrative transcriptomic analysis of SLE reveals IFN-driven cross-talk between immune cells
Panwar, B.; Schmiedel, B. J.; Liang, S.; White, B.; Rodriquez, E.; Kalunian, K.; McKnight, A. J.; Soloff, R.; Seumois, G.; Vijayanand, P.; Ay, F.
10.1101/2020.04.27.065227 — genomics — Posted on 2020-04-29
348 In silico Structural Characterization of Class II Plant Defensins from Arabidopsis thaliana
Costa, L. M.; Pires, A. S.; Damaceno, N. B.; Rigueiras, P. O.; Maximiano, M. R.; Franco, O. L.; Porto, W. F.
10.1101/2020.04.27.065185 — bioinformatics — Posted on 2020-04-29
353 PtrR (YneJ) is a novel E. coli transcription factor regulating the putrescine stress response and glutamate utilization
Rodionova, I. A.; Gao, Y.; Sastry, A. V.; Monk, J.; wong, n.; Szubin, R.; Lim, H.; Zhang, Z.; Saier, M. H.; Palsson, B. O.
10.1101/2020.04.27.065417 — microbiology — Posted on 2020-04-29
355 A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity
Scopino, K.; Williams, E.; Elsayed, A.; Barr, W. A.; Krizanc, D.; Thayer, K. M.; Weir, M. P.
10.1101/2020.04.28.058271 — biophysics — Posted on 2020-04-29
356 Tumor invasion as non-equilibrium phase separation
Kang, W.; Ferruzzi, J.; Spatarelu, C.-P.; Han, Y. L.; Sharma, Y.; Koehler, S.; Butler, J. P.; Roblyer, D.; Zaman, M. H.; Guo, M.; Chen, Z.; Pegoraro, A. F.; Fredberg, J. J.
10.1101/2020.04.28.066845 — biophysics — Posted on 2020-04-29
357 Rational design of protein-specific folding modifiers
Das, A.; Yadav, A.; Gupta, M.; R, P.; Terse, V. L.; Vishvakarma, V.; Singh, S.; Nandi, T.; Mandal, K.; Gosavi, S.; Das, R.; Ainavarapu, S. R. K.; Maiti, S.
10.1101/2020.04.28.064113 — biophysics — Posted on 2020-04-29
358 The preservation of ancient DNA in archaeological fish bone
Ferrari, G.; Cuevas, A.; Gondek-Wyrozemska, A. T.; Ballantyne, R.; Kersten, O.; Palsdottir, A. H.; van der Jagt, I.; Hufthammer, A.-K.; Ystgaard, I.; Wickler, S.; Bigelow, G. F.; Harland, J.; Nicholson, R.; Orton, D.; Clavel, B.; Boessenkool, S.; Barrett, J. H.; Star, B.
10.1101/2020.04.27.063677 — evolutionary biology — Posted on 2020-04-29
361 Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
Gao, L.; Emperle, M.; Guo, Y.; Grimm, S. A.; Ren, W.; Adam, S.; Uryu, H.; Zhang, Z.-M.; Chen, D.; Yin, J.; Dukatz, M.; Anteneh, H.; Jurkowska, R. Z.; Lu, J.; Wang, Y.; Bashtrykov, P.; Wade, P. A.; Wang, G. G.; Jeltsch, A.; Song, J.
10.1101/2020.04.27.064386 — genetics — Posted on 2020-04-29
365 Titration of in-cellula affinities of protein-protein interactions
Cluet, D.; Vergier, B.; Levy, N.-P.; Dehau, L.; Thurman, A.; Amri, I.; Spichty, M.
10.1101/2020.04.27.063552 — biochemistry — Posted on 2020-04-29
367 Neural correlates of winning and losing fights in poison frog tadpoles
Fischer, E. K.; Alvarez, H.; Lagerstrom, K. M.; McKinney, J. E.; Petrillo, R.; Ellis, G.; O'Connell, L. A.
10.1101/2020.01.27.922286 — neuroscience — Posted on 2020-04-29
368 Dentate gyrus population activity during immobility supports formation of precise memories
Pofahl, M.; Nikbakht, N.; Haubrich, A. N.; Nguyen, T.; Masala, N.; Braganza, O.; Macke, J. H.; Ewell, L. A.; Golcuk, K.; Beck, H.
10.1101/2020.03.05.978320 — neuroscience — Posted on 2020-04-29
371 A meiosis-specific factor MRM/C19orf57 modulates localization of RAD51 and DMC1 recombinases to DSBs in mouse meiotic recombination
Takemoto, K.; Tani, N.; Takada, Y.; Fujimura, S.; Tanno, N.; Yamane, M.; Okamura, K.; Sugimoto, M.; Araki, K.; Ishiguro, K.-i.
10.1101/2020.02.14.950204 — molecular biology — Posted on 2020-04-29
374 Characterising the epidemic spread of Influenza A/H3N2 within a city through phylogenetics
Müller, N. F.; Wüthrich, D.; Goldman, N.; Sailer, N.; Saalfrank, C.; Brunner, M.; Augustin, N.; Seth-Smith, H. M.; Hollenstein, Y.; Syedbasha, M.; Lang, D.; Neher, R. A.; Dubuis, O.; Naegele, M.; Buser, A.; Nickel, C. H.; Ritz, N.; Zeller, A.; Lang, B. M.; Hadfield, J.; Bedford, T.; Battegay, M.; Schneider-Sliwa, R.; Egli, A.; Stadler, T.
10.1101/2020.04.27.052225 — evolutionary biology — Posted on 2020-04-29
375 Actin binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II
Hayakawa, Y.; Takaine, M.; Imai, T.; Yamada, M.; Hirose, K.; Ngo, K. X.; Kodera, N.; Tokuraku, K.; Numata, O.; Nakano, K.; Uyeda, T.
10.1101/2020.04.14.041046 — biophysics — Posted on 2020-04-29
376 Exploring the upper pH limits of nitrite oxidation: diversity, ecophysiology, and adaptive traits of haloalkalitolerant Nitrospira
Daebeler, A.; Kitzinger, K.; Koch, H.; Herbold, C. W.; Steinfeder, M.; Schwarz, J.; Zechmeister, T.; Karst, S. M.; Albertsen, M.; Nielsen, P. H.; Wagner, M.; Daims, H.
10.1101/2020.03.05.977850 — microbiology — Posted on 2020-04-29
378 Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity
Parks, S.; Gao, T.; Jimenez Awuapura, N.; Ayathamattam, J.; Chabosseau, P. L.; Marchetti, P.; Johnson, P.; Bosco, D.; Kalvakolanu, D. V.; Valdivia, H. H.; Rutter, G. A.; Leclerc, I.
10.1101/2020.04.23.053322 — cell biology — Posted on 2020-04-29
380 Fast multi-directional DSLM for confocaldetection without striping artifacts
Ricci, P.; Sancataldo, G.; Gavryusev, V.; Franceschini, A.; Muellenbroich, C.; Silvestri, L.; Pavone, F. S.
10.1101/2020.04.06.027037 — biophysics — Posted on 2020-04-29
381 CReSCENT: CanceR Single Cell ExpressioN Toolkit
Mohanraj, S.; Diaz-Mejia, J. J.; Pham, M.; Elrick, H.; Husic, M.; Rashid, S.; Luo, P.; Bal, P.; Lu, K.; Patel, S.; Mahalanabis, A.; Naidas, A.; Christensen, E.; Croucher, D.; Richards, L.; Shooshtari, P.; Brudno, M.; Ramani, A.; Pugh, T. J.
10.1101/2020.03.27.012740 — bioinformatics — Posted on 2020-04-29
382 Anaerobic microbial degradation of protein and lipid macromolecules in subarctic marine sediment
Pelikan, C.; Wasmund, K.; Glombitza, C.; Hausmann, B.; Herbold, C.; Flieder, M.; Loy, A.
10.1101/2020.04.27.061291 — microbiology — Posted on 2020-04-29
383 Population dynamics analysis of Saccharomyces cerevisiae deletion library during fed-batch cultivation using Bar-seq
Wehrs, M.; Thompson, M.; Banerjee, D.; Prahl, J.-P.; Barcelos, C. A.; Moon, J.; Morella, N. M.; Costello, Z.; Keasling, J. D.; Shih, P. M.; Tanjore, D.; Mukhopadhyay, A.
10.1101/2020.04.27.064675 — microbiology — Posted on 2020-04-29
384 The draft genome sequence of herbaceous diploid bamboo Raddia distichophylla
Li, W.; Shi, C.; Li, K.; Zhang, Q.; Tong, Y.; Zhang, Y.; Wang, J.; Clark, L.; Gao, L.-z.
10.1101/2020.04.27.064089 — genomics — Posted on 2020-04-29
385 Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation
Ren, W.; Fan, H.; Grimm, S. A.; Guo, Y.; Kim, J. J.; Li, L.; Petell, C. J.; Tan, X.-F.; Zhang, Z.-M.; Coan, J. P.; Yin, J.; Gao, L.; Cai, L.; Detrick, B.; Cetin, B.; Patel, D. J.; Wang, Y.; Cui, Q.; Strahl, B. D.; Gozani, O.; Miller, K. M.; O'Leary, S. E.; Wade, P. A.; Wang, G. G.; Song, J.
10.1101/2020.04.27.064493 — genetics — Posted on 2020-04-29
386 Universal NicE-seq for high resolution accessible chromatin profiling for formaldehyde fixed and FFPE tissues
Chin, H. G.; Sun, Z.; Vishnu, U. S.; Hao, C.; Cejas, P.; Spracklin, G.; Esteve, P.-O.; Xu, S.-y.; Long, H. W.; Pradhan, S.
10.1101/2020.04.27.064592 — genetics — Posted on 2020-04-29
387 Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution
Furubayashi, T.; Ueda, K.; Bansho, Y.; Motooka, D.; Nakamura, S.; Ichihashi, N.
10.1101/728659 — evolutionary biology — Posted on 2020-04-29
397 On a reef far, far away: Offshore transport of floodwaters following extreme storms impacts sponge health and associated microbial communities
Shore, A.; Sims, J. A.; Grimes, M.; Howe-Kerr, L. I.; Stadler, L.; Sylvan, J. B.; Shamberger, K. E.; Davies, S. W.; Santiago-Vasquez, L. Z.; Correa, A. M.
10.1101/2020.04.27.064568 — microbiology — Posted on 2020-04-29
400 Biomarkers to distinguish bacterial from viral pediatric clinical pneumonia in a malaria endemic setting
Gillette, M. A.; Mani, D. R.; Uschnig, C.; Pelle, K.; Madrid, L.; Acacio, S.; Lanaspa, M.; Alonso, P.; Valim, C.; Carr, S. A.; Schaffner, S.; MacInnis, B.; Milner, D.; Bassat, Q.; Wirth, D.
10.1101/2020.04.27.036277 — genomics — Posted on 2020-04-29
403 TCGA Pan-Cancer genomic analysis of Alternative Lengthening of Telomeres (ALT) related genes
Armendariz-Castillo, I.; Lopez-Cortes, A.; Garcia-Cardenas, J.; Guevara-Ramirez, P.; Leone, P. E.; Perez-Villa, A.; Yumiceba, V.; Zambrano, A. K.; Guerrero, S.; Paz-y-Mino, C.
10.1101/2020.04.27.063610 — cancer biology — Posted on 2020-04-29
404 Resolving an underrepresented circulating tumor cell population in lung cancer enabled by Hexokinase 2 analysis
Yang, L.; Yan, X.; Chen, J.; Zhan, Q.; Hua, Y.; Xu, S.; Dong, Y.; Li, Z.; Wang, Z.; Zuo, D.; Xue, M.; Tang, Y.; Herschman, H. R.; Lu, S.; Shi, Q.; Wei, W.
10.1101/2020.04.27.064345 — cancer biology — Posted on 2020-04-29
405 Decoding the functional Fes kinase signaling network topology in a lymphocyte model
Helbig, A. O.; Kofler, M.; Gish, G.; Sriraja, L.; Lorenzen, K.; Tucholska, M.; Zhang, C.; Roth, F. P.; Colwill, K.; Pawson, T.; Petsalaki, E.
10.1101/125088 — systems biology — Posted on 2020-04-29
406 Experimentally revealed stochastic preferences for multi-component choice options
Pastor-Bernier, A.; Volkmann, K.; Stasiak, A.; Grabenhorst, F.; Schultz, W.
10.1101/832881 — neuroscience — Posted on 2020-04-29
407 A validation scale to determine the readiness of environmental DNA assays for routine species monitoring
Thalinger, B.; Deiner, K.; Harper, L. R.; Rees, H. C.; Blackman, R. C.; Sint, D.; Traugott, M.; Goldberg, C. S.; Bruce, K.
10.1101/2020.04.27.063990 — molecular biology — Posted on 2020-04-29
408 Postnatal expansion, maturation and functionality of MR1 T cells in humans
Swarbrick, G. M.; Gela, A.; Cansler, M. E.; Null, M. D.; Duncan, R. B.; Nemes, E.; Shey, M.; Nsereko, M.; Mayanja-Kizza, H.; Kiguli, S.; Koh, J.; Hanekom, W.; Hatherill, M.; Lancioni, C.; Lewinsohn, D. M.; Scriba, T.; Lewinsohn, D. A.
10.1101/2019.12.20.882746 — immunology — Posted on 2020-04-29
410 Phenotypic switching and adaptive strategies of cancer cells in response to stress: insights from live cell imaging and mathematical modeling
Nam, A.; Mohanty, A.; Bhattacharya, S.; Kotnala, S.; Achuthan, S.; Hari, K.; Nathan, A.; Rangarajan, G.; Massarelli, E.; Levine, H.; Jolly, M. K.; Kulkarni, P.; Salgia, R.
10.1101/2020.04.06.028472 — cancer biology — Posted on 2020-04-29
412 Repeated parallel losses of inflexed stamens in Moraceae: phylogenomics and generic revision of the tribe Moreae and the reinstatement of the tribe Olmedieae (Moraceae)
Gardner, E. M.; Garner, M.; Cowan, R.; Dodsworth, S.; Epitawalage, N.; Maurin, O.; Arifiani, D.; Sahromi, S.; Baker, W. J.; Forest, F.; Zerega, N. J.; Monro, A. K.; Hipp, A. L.
10.1101/2020.04.08.030452 — plant biology — Posted on 2020-04-29
413 Genome-Enabled Discovery of Anthraquinone Biosynthesis in Senna tora
Kang, S.-H.; Pandey, R. P.; Lee, C.-M.; Sim, J.-S.; Jeong, J.-T.; Choi, B.-S.; Jung, M.; Won, S. Y.; Oh, T.-J.; Yu, Y.; Kim, N.-H.; Lee, O. R.; Lee, T.-H.; Bashyal, P.; Kim, T.-S.; Kim, C.-K.; Kim, J. S.; Ahn, B. O.; Rhee, S. Y.; Sohng, J. K.
10.1101/2020.04.27.063495 — plant biology — Posted on 2020-04-29
414 14-3-3ζ mediates an alternative, non- thermogenic mechanism to reduce heat loss and improve cold tolerance
Diallo, K.; Dussault, S.; Noll, C.; Lopez, A. F.; Rivard, A.; Carpentier, A. C.; Lim, G.
10.1101/853184 — physiology — Posted on 2020-04-29
416 Metabolic exchange and energetic coupling between nutritionally stressed bacterial species, the possible role of QS molecules
RANAVA, D.; Backes, C.; Karthikeyan, G.; Ouari, O.; Soric, A.; Guiral, M.; Cardenas, M. L.; Giudici-Orticoni, M. T.
10.1101/2020.04.27.063917 — microbiology — Posted on 2020-04-29
420 Genomic characterization of a diazotrophic microbiota associated with maize aerial root mucilage
Higdon, S. M.; Pozzo, T.; Kong, N.; Huang, B. C.; Yang, M. L.; Jeannotte, R.; Brown, C. T.; Bennett, A. B.; Weimer, B. C.
10.1101/2020.04.27.064337 — genomics — Posted on 2020-04-29
421 Coding de novo mutations identified by WGS reveal novel orofacial cleft genes
Bishop, M.; Diaz Perez, K. K.; Sun, M.; Ho, S.; Chopra, P.; Mukhopadhyay, N.; Hetmanski, J.; Taub, M.; Moreno-Uribe, L.; Valencia-Ramirez, L. C.; Restrepo Muneton, C.; Wehby, G.; Hecht, J.; Deleyiannis, F.; Weinberg, S.; Wu-Chou, Y. H.; Chen, P.; Brand, H.; Epstein, M.; Ruczinski, I.; Murray, J.; Beaty, T.; Feingold, E.; Lipinski, R.; Cutler, D.; Marazita, M.; Leslie, E.
10.1101/2020.04.01.019927 — genetics — Posted on 2020-04-29
424 A functional screen of translated pancreatic lncRNAs identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation
Gaertner, B.; van Heesch, S.; Schneider-Lunitz, V.; Schulz, J. F.; Witte, F.; Blachut, S.; Nguyen, S.; Wong, R.; Matta, I.; Hubner, N.; Sander, M.
10.1101/2020.04.28.062679 — developmental biology — Posted on 2020-04-29
425 Predicting microbiomes through a deep latent space
Garcia-Jimenez, B.; Munoz, J.; Cabello, S.; Medina, J.; Wilkinson, M. D.
10.1101/2020.04.27.063974 — bioinformatics — Posted on 2020-04-28
428 Detection of Merkel cell polyomavirus using whole exome sequencing data
Garcia-Mulero, S.; Moratalla-Navarro, F.; Curiel-Olmo, S.; Moreno, V.; Pedro Vaque, J.; Sanz-Pamplona, R.; Piulats, J. M.
10.1101/2020.04.27.063214 — bioinformatics — Posted on 2020-04-28
430 EPIP: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles
Hu, W.; Qiu, S.; Li, Y.; Lin, X.; Zhang, L.; Xiang, H.; Han, X.; Chen, L.; Li, S.; Li, W.; Ren, Z.; Hou, G.; Lin, Z.; Lu, J.; Liu, G.; Li, B.; Lee, L.
10.1101/567081 — bioinformatics — Posted on 2020-04-28
432 Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex
Shireby, G.; Davies, J.; Francis, P.; Burrage, J.; Walker, E.; Neilson, G.; Dahir, A.; Thomas, A.; Love, S.; Smith, R.; Lunnon, K.; Kumari, M.; Schalkwyk, L.; Morgan, K.; Brookes, K.; Hannon, E.; Mill, J.
10.1101/2020.04.27.063719 — genomics — Posted on 2020-04-28
433 Does diversity beget diversity in microbiomes?
Madi, N. J.; Vos, M.; Murall, C. L.; Legendre, P.; Shapiro, B. J.
10.1101/612739 — evolutionary biology — Posted on 2020-04-28
434 MicroRNA composition delineates cardiosphere-derived cell and mesenchymal stem cell extracellular vesicles
Walravens, A.-S.; Smolgovsky, S.; Li, L.; Kelly, L.; Antes, T.; Peck, K.; Quon, T.; Marban, L.; Berman, B.; Borlado, L.; de Couto, G.
10.1101/2020.04.28.066290 — cell biology — Posted on 2020-04-28
435 GORASPs link Golgi cisternae laterally to stabilize the rims and prevent vesiculation
Grond, R.; Veenendaal, T.; Duran, J.; Raote, I.; Corstjens, S.; Delfgou, L.; El Haddouti, B.; Malhotra, V.; Rabouille, C.
10.1101/2020.04.28.066381 — cell biology — Posted on 2020-04-28
436 Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast
Zhang, Y.; Kuster, D.; Schmidt, T.; Kirrmaier, D.; Nübel, G.; Ibberson, D.; Benes, V.; Hombauer, H.; Knop, M.; Jäschke, A.
10.1101/2020.04.28.065920 — cell biology — Posted on 2020-04-28
437 Clearance of senescent cells during cardiac ischemia-reperfusion injury improves heart recovery following myocardial infarction
Dookun, E.; Walaszczyk, A.; Redgrave, R.; Palmowski, P.; Tual-Chalot, S.; Suwana, A.; Chapman, J.; Jirkovsky, E.; Donastorg, L.; Gill, E.; Santin, Y.; Yausep, o. E.; Mialet-Perez, J.; Owens, W. A.; Grieve, D. G.; Spyridopoulos, I.; Taggart, M.; Arthur, H.; Passos, J. F.; Richardson, G. D.
10.1101/2020.04.28.065789 — cell biology — Posted on 2020-04-28
440 Electron Event Representation (EER) data enables efficient cryoEM file storage with full preservation of spatial and temporal resolution
Guo, H.; Franken, E.; Deng, Y.; Benlekbir, S.; Singla Lezcano, G.; Janssen, B.; Yu, L.; Ripstein, Z. A.; Tan, Y. Z.; Rubinstein, J. L.
10.1101/2020.04.28.066795 — biophysics — Posted on 2020-04-28
444 Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within mosquito
Liu, K.; Xiao, C.; Xi, S.; Hameed, M.; Wahaab, A.; Shao, D.; Li, Z.; Li, B.; Wei, J.; Qiu, Y.; Miao, D.; Zhu, H.; Ma, Z.
10.1101/2020.04.28.065904 — microbiology — Posted on 2020-04-28
447 A Modular Framework for Multiscale Spatial Modeling of Viral Infection and Immune Response in Epithelial Tissue
Sego, T. J.; Aponte-Serrano, J. O.; Ferrari-Gianlupi, J.; Heaps, S.; Quardokus, E. M.; Glazier, J. A.
10.1101/2020.04.27.064139 — bioengineering — Posted on 2020-04-28
448 Generation and Validation of Versatile Inducible CRISPRi Embryonic Stem Cell and Mouse Models
Wu, X.; Li, R.; Xia, X.; Wang, X.; Sun, X.; Dai, Z.; Huo, D.; Zheng, H.; Xiong, H.; He, A.
10.1101/2020.04.28.065854 — genetics — Posted on 2020-04-28
451 Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.
Mycroft-West, C.; Su, D.; Pagani, I.; Rudd, T.; Elli, S.; Guimond, S.; Miller, G.; Meneghetti, M.; Nader, H.; Li, Y.; Nunes, Q.; Procter, P.; Mancini, N.; Clementi, M.; Bisio, A.; Forsyth, N.; Turnbull, J.; Guerrini, M.; Fernig, D.; Vicenzi, E.; Yates, E.; Lima, M.; Skidmore, M. A.
10.1101/2020.04.28.066761 — biochemistry — Posted on 2020-04-28
453 Magnetoencephalographic Signatures of Hierarchical Rule Learning in Newborns
Moser, J.; Schleger, F.; Weiss, M.; Sippel, K.; Dehaene-Lambertz, G.; Preissl, H.
10.1101/2020.04.28.065482 — neuroscience — Posted on 2020-04-28
454 Self-reported sleep problems are related to cortical thinning in aging but not memory decline and amyloid-β accumulation - results from the Lifebrain consortium
Fjell, A.; Sorensen, O.; Amlien, I. K.; Bartres-Faz, D.; Brandmaier, A.; Macia, D.; Buchmann, N.; Demuth, I.; Drevon, C. A.; Duzel, S.; Ebmeier, K.; Ghisletta, P.; Idland, A.-V.; Kietzmann, T.; Kievit, R. A.; Kuhn, S. A.; Lindenberger, U.; Magnussen, F.; Mowinckel, A. M.; Nyberg, L.; Roe, J. M.; Sexton, C.; Sole-Padulles, C.; Pudas, S.; Vidal-Pineiro, D.; Sederevicius, D.; Suri, S.; Wagner, G.; Watne, L. O.; Westerhausen, R.; Zsoldos, E.; Walhovd, K. B.
10.1101/2020.04.28.065474 — neuroscience — Posted on 2020-04-28
455 Microsaccades during high speed continuous visual search
Martin, J. G.; Davis, C. E.; Riesenhuber, M.; Thorpe, S. J.
10.1101/2020.04.28.062042 — neuroscience — Posted on 2020-04-28
457 Single-cell RNA-seq analysis of human iPSC-derived motor neurons resolves early and predictive ALS signatures
Ho, R.; Workman, M. J.; Mathkar, P.; Wu, K.; Kim, K. J.; ORourke, J. G.; Kellogg, M.; Montel, V.; Banuelos, M. G.; Aladesuyi, O.; Diaz-Garcia, S.; Oheb, D.; Huang, S.; Khrebtukova, I.; Watson, L.; Ravits, J.; Taylor, K.; Baloh, R. H.; Svendsen, C. N.
10.1101/2020.04.27.064584 — neuroscience — Posted on 2020-04-28
458 Nano-positioning and tubuline conformation determine transport of mitochondria along microtubules
Van Steenbergen, V.; Lavoie-Cardinal, F.; Kazwiny, Y.; Decet, M.; Martens, T.; Verstreken, P.; Boesmans, W.; De Koninck, P.; Vanden Berghe, P.
10.1101/2020.04.27.064766 — neuroscience — Posted on 2020-04-28
459 Adaptive synaptic plasticity maintains CRH neuron output during chronic glucocorticoid exposure
Rasiah, N.; Rosenegger, D.; Daviu Abant, N.; Fuzesi, T.; Muir, J.; Sterley, T. L.; Bains, J. S.
10.1101/2020.04.27.064725 — neuroscience — Posted on 2020-04-28
460 Sleep Efficiency Relates to Hippocampal Integrity Decline in β-Amyloid Positive Adults
Grydeland, H.; Sederevicius, D.; Wang, Y.; Bartres-Faz, D.; Bertram, L.; Dobricic, V.; Düzel, S.; Ebmeier, K. P.; Lindenberger, U.; Nyberg, L.; Pudas, S.; Sexton, C. E.; Sole-Padulles, C.; Walhovd, K. B.; Fjell, A. M.
10.1101/2020.04.28.061184 — neuroscience — Posted on 2020-04-28
462 An essential role for MEF2C in the cortical response to loss of sleep
Bjorness, T. E.; Kulkarni, A.; Rybalchenko, V.; Suzuki, A.; Bridges, C.; Harrington, A. J.; Cowan, C. W.; Takahashi, J. S.; Konopka, G.; Greene, R. W.
10.1101/2020.04.27.064535 — neuroscience — Posted on 2020-04-28
465 The Alzheimer's disease protective P522R variant of PLCG2, consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell function.
Maguire, E.; Menzies, G. E.; Phillips, T.; Sasner, M.; Williams, H. M.; Czubala, M. A.; Evans, N.; Cope, E. L.; Sims, R. C.; Howell, G.; Lloyd-Evans, E.; Williams, J.; Allen, N. D.; Taylor, P. R.
10.1101/2020.04.27.059600 — neuroscience — Posted on 2020-04-28
466 Functional characterization of Neurofilament Light b splicing and misbalance in zebrafish
Demy, D. L.; Campanari, M.-L.; Munoz-Ruiz, R.; Durham, H. D.; Gentil, B.; Kabashi, E.
10.1101/2020.04.27.064063 — neuroscience — Posted on 2020-04-28
467 Protein synthesis is suppressed in sporadic and familial Parkinson's Disease by LRRK2
Deshpande, P.; Flinkman, D.; Hong, Y.; Goltseva, E.; Siino, V.; Sun, L.; Peltonen, S.; Elo, L.; Kaasinen, V.; James, P.; Coffey, E. T.
10.1101/2020.04.27.053694 — neuroscience — Posted on 2020-04-28
471 A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
Ramachandran, S.; Banerjee, N.; Bhattacharya, R.; Touroutine, D.; Lambert, C. M.; Schoofs, L.; Beets, I.; Francis, M. M.
10.1101/2020.04.27.064550 — neuroscience — Posted on 2020-04-28
477 Entraining alpha activity using visual stimulation in patients with chronic musculoskeletal pain. A feasibility study.
Arendsen, L. J.; Henshaw, J.; Brown, C. A.; Sivan, M.; Taylor, J. R.; Trujillo-Barreto, N. J.; Casson, A. J.; Jones, A. K. P.
10.1101/2020.04.27.063339 — neuroscience — Posted on 2020-04-28
478 TrkB activation in Parvalbumin interneurons orchestrates cortical plasticity
Winkel, F.; Voigt, M. B.; Didio, G.; Mateo, S.; Jetsonen, E.; Llach Pou, M.; Steinzeig, A.; Ryazantseva, M.; Harkki, J.; Englund, J.; Khirug, S.; Rivera, C.; Palva, S.; Taira, T.; Lauri, S.; Umemori, J.; Castren, E.
10.1101/2020.04.27.063503 — neuroscience — Posted on 2020-04-28
480 Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
McMillan, K. J.; Banks, P. J.; Hellel, F. L. N.; Carmichael, R. E.; Clairfeuille, T.; Evans, A. J.; Heesom, K. J.; Lewis, P.; Collins, B. M.; Bashir, Z. I.; Henley, J. M.; Wilkinson, K. A.; Cullen, P. J.
10.1101/2020.04.27.063248 — molecular biology — Posted on 2020-04-28
481 Forest Saccharomyces paradoxus are robust to seasonal biotic and abiotic changes
Boynton, P. J.; Wloch-Salamon, D.; Landermann, D.; Holtgrewe Stukenbrock, E. J.
10.1101/2020.04.27.063289 — evolutionary biology — Posted on 2020-04-28
483 Genetic differences between extreme and composite constitution types from whole exome sequences reveal actionable variations
Abbas, T.; Kutum, R.; Pandey, R.; Dakle, P.; Narang, A.; Manchanda, V.; Patil, R.; Aggarwal, D.; Bansal, G.; Sharma, P.; Chaturvedi, G.; Girase, B.; Srivastava, A.; Juvekar, S.; Dash, D.; Prasher, B.; Mukerji, M.
10.1101/2020.04.24.059006 — genomics — Posted on 2020-04-28
484 Context-dependent extinction learning emerging from raw sensory inputs: A reinforcement learning approach
Walther, T.; Diekmann, N.; Vijayabaskaran, S.; Donoso, J. R.; Manahan-Vaughan, D.; Wiskott, L.; Cheng, S.
10.1101/2020.04.27.059121 — neuroscience — Posted on 2020-04-28
486 Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers
Bordeira-Carrico, R.; Teixeira, J.; Duque, M.; Galhardo, M.; Ribeiro, D.; Dominguez-Acemel, R.; Firbas, P. N.; Tena, J. J.; Eufrasio, A.; Marques, J.; Ferreira, F.; Freitas, T.; Carneiro, F.; Gomez-Skarmeta, J. L.; Bessa, J.
10.1101/2020.04.27.064220 — genomics — Posted on 2020-04-28
488 Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur
Jin, Z.; Zhao, Y.; Sun, Y.; Zhang, B.; Wang, H.; Wu, Y.; Zhu, Y.; Zhu, C.; Hu, T.; Du, X.; Duan, Y.; Yu, J.; Yang, X.; Yang, X.; Yang, K.; Liu, X.; Guddat, L. W.; Xiao, G.; Zhang, L.; Yang, H.; Rao, Z.
10.1101/2020.04.09.033233 — biochemistry — Posted on 2020-04-28
491 A transient role of primary cilia in controlling direct versus indirect neurogenesis in the developing cerebral cortex
Theil, T.; Hasenpusch-Theil, K.; Laclef, C.; Colligan, M.; Fitzgerald, E.; Howe, K.; Carroll, E.; Abrams, S.; Reiter, J. F.; Schneider-Maunoury, S.
10.1101/2020.04.28.065615 — developmental biology — Posted on 2020-04-28
492 Site-specific effects of neurosteroids on GABAA receptor activation and desensitization
Sugasawa, Y.; Cheng, W. W.; Bracamontes, J.; Chen, Z.-W.; Wang, L.; Germann, A. L.; Pierce, S. R.; Senneff, T. C.; Krishnan, K.; Reichert, D. E.; Covey, D. F.; Akk, G.; Evers, A.
10.1101/2020.04.27.063404 — biophysics — Posted on 2020-04-28
494 Latrophilin 2 controls vascular morphogenesis and function by inhibiting endothelial cell adhesion and YAP/TAZ mechanosignaling
Camillo, C.; Facchinello, N.; Villari, G.; Gays, D.; Gioelli, N.; Sandri, C.; Arese, M.; Tamagnone, L.; Valdembri, D.; Santoro, M. M.; Serini, G. G.
10.1101/2020.04.28.065979 — cell biology — Posted on 2020-04-28
497 Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer's disease model
Abdul Halim, M.; Rosli, I. M.; Muhamad Jaafar, S. S.; Hoi Min, O.; Pui Wei, L.; Shamsuddin, S.; Najimudin, N.; Azzam, G.
10.1101/2020.04.27.063107 — pharmacology and toxicology — Posted on 2020-04-28
498 De novo mutation in ancestral generations evolves haplotypes contributing to disease
Coban Akdemir, Z.; Song, X.; Pehlivan, D.; Karaca, E.; Bayram, Y.; Gambin, T. L.; Jhangiani, S.; muzny, d. m.; Lewis, R.; Baylor Hopkins Center for Mendelian Genomics, ; Liu, P.; Boerwinkle, E.; Hamosh, A.; Gibbs, R. A.; Sutton, R.; Sobreira, N.; Carvalho, C. M. B.; Posey, J.; Shaw, C. A.; Valle, D.; Lupski, J. R.
10.1101/2020.04.27.064824 — genomics — Posted on 2020-04-28
501 Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations
Martin, A. R.; Atkinson, E. G.; Chapman, S. B.; Stevenson, A.; Stroud, R. E.; Abebe, T.; Akena, D.; Alemayehu, M.; Ashaba, F. K.; Atwoli, L.; Bowers, T.; Chibnik, L. B.; Daly, M. J.; DeSmet, T.; Dodge, S.; Fekadu, A.; Ferriera, S.; Gelaye, B.; Gichuru, S.; Injera, W.; James, R.; Kariuki, S. M.; Kigen, G.; Koenen, K. C.; Kwobah, E.; Kyebuzibwa, J.; Majara, L.; Musinguzi, H.; Mwema, R. M.; Neale, B. M.; Newman, C. P.; Newton, C. R. J. C.; Pickrell, J. K.; Ramesar, R.; Shiferaw, W.; Stein, D. J.; Teferra, S.; van der Merwe, C.; Zingela, Z.; NeuroGAP-Psychosis Consortium,
10.1101/2020.04.27.064832 — genomics — Posted on 2020-04-28
502 A versatile system to introduce clusters of genomic double-strand breaks in large cell populations
Kolb, T.; Khalid, U.; Simovic, M.; Ratnaparkhe, M.; Wong, J.; Jauch, A.; Schmezer, P.; Rode, A.; Sebban, S.; Haag, D.; Hergt, M.; Devens, F.; Buganim, Y.; Zapatka, M.; Lichter, P.; Ernst, A.
10.1101/2020.04.27.064105 — genomics — Posted on 2020-04-28
504 ProSolo: Accurate Variant Calling from Single Cell DNA Sequencing Data
Lähnemann, D.; Köster, J.; Fischer, U.; Borkhardt, A.; McHardy, A. C.; Schönhuth, A.
10.1101/2020.04.27.064071 — bioinformatics — Posted on 2020-04-28
505 IPSC-derived midbrain astrocytes from Parkinson's disease patients carrying pathogenic SNCA mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release
Barbuti, P. A.; Antony, P.; Novak, G.; Larsen, S. B.; Berenguer-Escuder, C.; Santos, B. F.; Massart, F.; Grossmann, D.; Shiga, T.; Ishikawa, K.-i.; Akamatsu, W.; Finkbeiner, S.; Hattori, N.; Krueger, R.
10.1101/2020.04.27.053470 — neuroscience — Posted on 2020-04-28
508 Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genes
Barnabei, L.; Lamrini, H.; Castela, M.; Jeremiah, N.; Stolzenberg, M.-C.; Chentout, L.; Mirshavalad, S.; Bouafia, A.; Magerus, A.; Moncan, M.; Jacques, S.; Pelle, O.; Bondet, V.; Duffy, D.; Parisot, M.; Bras, M.; Uggenti, C.; Salomon, R.; Bodemer, C.; Rabant, M.; Cavazzana, M.; Miner, J. J.; Belot, A.; Hie, M.; Picard, C.; Bader-Meunier, B.; Kracker, S.; Rieux-Laucat, F.
10.1101/2020.04.27.046102 — immunology — Posted on 2020-04-28
509 Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)
McCrory, C.; Fiorito, G.; Hernandez, B.; Polidoro, S.; O'Halloran, A. M.; Hever, A.; NiCheallaigh, C.; Lu, A. T.; Horvath, S.; Vineis, P.; Kenny, R. A.
10.1101/2020.04.27.063164 — genomics — Posted on 2020-04-28
511 Long-term mark-recapture and growth data for large-sized migratory brown trout (Salmo trutta) from Lake Mjosa, Norway
Moe, S. J.; Nater, C. R.; Rustadbakken, A.; Vollestad, L. A.; Lund, E.; Qvenild, T.; Hegge, O.; Aass, P.
10.1101/544825 — ecology — Posted on 2020-04-28
514 High-throughput organoid screening enables engineering of intestinal epithelial composition
Mead, B. E.; Hattori, K.; Levy, L.; Vukovic, M.; Sze, D.; Matute, J. D.; Duan, J.; Langer, R.; Blumberg, R. S.; Ordovas-Montanes, J.; Shalek, A. K.; Karp, J. M.
10.1101/2020.04.27.063727 — bioengineering — Posted on 2020-04-28
518 METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes
CHEN, H.; Liu, Q.; Yu, D.; Natchiar, K.; Zhou, C.; Hsu, C.-h.; Hsu, P.-H.; Zhang, X.; Klaholz, B.; Gregory, R.; Cheng, X.; Shi, Y.
10.1101/2020.04.27.064162 — biochemistry — Posted on 2020-04-28
519 Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB
Reading, E.; Ahdash, Z.; Fais, C.; Ricci, V.; Wang-Kan, X.; Grimsey, E.; Stone, J. W.; Malloci, G.; Lau, A. M.; Findlay, H.; Konijnenberg, A.; Booth, P. J.; Ruggerone, P.; Vargiu, A. V.; Piddock, L. J. V.; Politis, A.
10.1101/2020.04.27.063511 — biochemistry — Posted on 2020-04-28
523 Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer
Guillot, J.; Dominici, C.; Lucchesi, A.; Nguyen, T. T. H.; Nigri, J.; Guillaumond, F.; Bigonnet, M.; Dusetti, N.; Etzerodt, A.; Lawrence, T.; Pudlo, P.; Hubert, F.; Scoazec, J.-Y.; van de Pavert, S. A.; Tomasini, R.; Chauvet, S.; Mann, F.
10.1101/2020.04.27.061648 — cancer biology — Posted on 2020-04-28
524 A near-chromosome level genome assembly of Anopheles stephensi
Chida, A. R.; Ravi, S.; Jayaprasad, S.; Paul, K.; Saha, J.; Suresh, C.; Whadgar, S.; Kumar, N.; Rao K, R.; Ghosh, C.; Choudhary, B.; Subramani, S.; Srinivasan, S.
10.1101/2020.04.27.063040 — genomics — Posted on 2020-04-28
525 Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation
Kolich, L. R.; Chang, Y.-T.; Coudray, N.; Giacometti, S. I.; MacRae, M. R.; Isom, G. L.; Teran, E. M.; Bhabha, G.; Ekiert, D. C.
10.1101/2020.04.27.064196 — microbiology — Posted on 2020-04-28
526 The role of the diencephalon in the guidance of thalamocortical axons in mice
Quintana-Urzainqui, I.; Hernandez-Malmierca, P.; Clegg, J.; Li, Z.; Kozic, Z.; Price, D. J.
10.1101/763201 — developmental biology — Posted on 2020-04-28
528 The Enterprise: A massive transposon carrying Spok meiotic drive genes
Vogan, A. A.; Ament-Velasquez, S. L.; Bastiaans, E.; Wallerman, O.; Saupe, S. J.; Suh, A.; Johannesson, H.
10.1101/2020.03.25.007153 — genomics — Posted on 2020-04-28
529 Inhibition of PIKfyve kinase prevents infection by EBOV and SARS-CoV-2
Kang, Y.-L.; Chou, Y.-Y.; Rothlauf, P. W.; Liu, Z.; Soh, T. K.; Cureton, D.; Case, J. B.; Chen, R. E.; Diamond, M. S.; Whelan, S. P. J.; Kirchhausen, T.
10.1101/2020.04.21.053058 — cell biology — Posted on 2020-04-28
530 Continuous lineage recording reveals rapid, multidirectional metastasis in a lung cancer xenograft model in mouse
Quinn, J. J.; Jones, M. G.; Okimoto, R. A.; Chan, M. M.; Yosef, N.; Bivona, T. G.; Weissman, J. S.
10.1101/2020.04.16.045245 — cancer biology — Posted on 2020-04-28
531 Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States
Altman, M. C.; Rinchai, D.; Baldwin, N.; Toufiq, M.; Whalen, E.; Garand, M.; Kabeer, B. A.; Alfaki, M.; Presnell, S.; Khaenam, P.; Benitez, A. A.; Mougin, F.; Thebault, P.; Chiche, L.; Jourde-Chiche, N.; Phillips, T.; Klintmalm, G.; O'Garra, A.; Berry, M.; Bloom, C.; Wilkinson, R. J.; Graham, C. M.; Lipman, M.; Lertmemongkolchai, G.; Bedognetti, D.; Thiebaut, R.; Kheradmand, F.; Mejias, A.; Ramilo, O.; Palucka, K.; Pascual, V.; Banchereau, J.; Chaussabel, D.
10.1101/525709 — immunology — Posted on 2020-04-28
532 Selection and local adaptation in capuchin monkeys revealed through fluorescence-activated cell sorting of feces (fecalFACS)
Orkin, J. D.; Montague, M. J.; Tejada-Martinez, D.; de Manuel, M.; del Campo, J.; Di Fiore, A.; Fontsere, C.; Hodgson, J. A.; Janiak, M. C.; Kuderna, L. F. K.; Lizano, E.; Niimura, Y.; Perry, G. H.; Tang, J.; Warren, W. C.; de Magalhaes, J. P.; Kawamura, S.; Marques-Bonet, T.; Krawetz, R.; Melin, A. D.
10.1101/366112 — genomics — Posted on 2020-04-28
533 Selection and local adaptation in capuchin monkeys revealed through fluorescence-activated cell sorting of feces (fecalFACS)
Orkin, J. D.; Montague, M. J.; Tejada-Martinez, D.; de Manuel, M.; del Campo, J.; Di Fiore, A.; Fontsere, C.; Hodgson, J. A.; Janiak, M. C.; Kuderna, L. F. K.; Lizano, E.; Niimura, Y.; Perry, G. H.; Tang, J.; Warren, W. C.; de Magalhaes, J. P.; Kawamura, S.; Marques-Bonet, T.; Krawetz, R.; Melin, A. D.
10.1101/366112 — genomics — Posted on 2020-04-28
534 Testing Structural Models of Psychopathology at the Genomic Level
Waldman, I. D.; Poore, H. E.; Luningham, J. M.; Yang, J.
10.1101/502039 — genomics — Posted on 2020-04-28
535 Testing Structural Models of Psychopathology at the Genomic Level
Waldman, I. D.; Poore, H. E.; Luningham, J. M.; Yang, J.
10.1101/502039 — genomics — Posted on 2020-04-28
538 NMR microsystem for label-free characterization of 3D nanoliter microtissues
Grisi, M.; Conley, G. M.; Rodriguez, K. J.; Riva, E.; Egli, L.; Moritz, W.; Lichtenberg, J.; Brugger, J.; Boero, G.
10.1101/2020.04.26.062141 — bioengineering — Posted on 2020-04-28
539 Open hardware low-cost system for behavioral experiments simultaneously with electrophysiological recordings.
Aguiar, L. A. A.; Vasconcelos, N. A. P.; Tunes, G. C.; Fontenele, A. J.; Nogueira, R. d. A.; Reyes, M. B.; Carelli, P. V.
10.1101/821843 — animal behavior and cognition — Posted on 2020-04-28
542 A footptrint of plant eco-geographic adaptation on the composition of the barley rhizosphere bacterial microbiota
Alegria Terrazas, R.; Balbirnie-Cumming, K.; Morris, J.; Hedley, P.; Russell, J.; Paterson, E.; Baggs, E.; Fridman, E.; Bulgarelli, D.
10.1101/2020.02.11.944140 — plant biology — Posted on 2020-04-28
543 cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use
Ehinger, Y.; Morisot, N.; Sakhai, S.; Phamluong, K.; Soneja, D.; Adrover, M.; Alvarez, V.; Ron, D.
10.1101/2020.01.07.898023 — neuroscience — Posted on 2020-04-28
546 Novel class of OTU deubiquitinases regulate substrate ubiquitinationupon Legionella infection
Shin, D.; Bhattacharya, A.; Cheng, Y.-L.; Alonso, M. C.; Mehdipour, A. R.; Noort, G. J. v. d. H. v.; Ovaa, H.; Hummer, G.; Dikic, I.
10.1101/2020.04.25.060954 — molecular biology — Posted on 2020-04-28
547 Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly
Reed, J. C.; Solas, D.; Kitaygorodskyy, A.; Freeman, B.; Ressler, D. T. B.; Phuong, D. J.; Swain, J. V.; Matlack, K.; Hurt, C. R.; Lingappa, V. R.; Lingappa, J. R.
10.1101/2020.03.18.998088 — microbiology — Posted on 2020-04-28
549 Structural insight into tanapoxvirus mediated inhibition of apoptosis
Suraweera, C. D.; Anasir, M. I.; Chugh, S.; Javorsky, A.; Impey, R. E.; Hasan Zadeh, M.; Soares da Costa, T. P.; Hinds, M. G.; Kvansakul, M.
10.1101/2020.01.21.914671 — microbiology — Posted on 2020-04-28
550 Expanding magnetic organelle biogenesis in the domain Bacteria
Lin, W.; Zhang, W.; Paterson, G. A.; Zhu, Q.; Zhao, X.; Knight, R.; Bazylinski, D. A.; Roberts, A. P.; Pan, Y.
10.1101/2020.04.27.061960 — microbiology — Posted on 2020-04-28
551 Chromosome-level and haplotype-resolved genome assembly enabled by high-throughput single-cell sequencing of gamete genomes
Campoy, J. A.; Sun, H.; Goel, M.; Jiao, W.-B.; Folz-Donahue, K.; Kukat, C.; Rubio, M.; Ruiz, D.; Huettel, B.; Schneeberger, K.
10.1101/2020.04.24.060046 — genomics — Posted on 2020-04-28
552 Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer
Kar, S.; Considine, D.; Tyrer, J.; Plummer, J.; Chen, S.; Dezem, F.; Barbeira, A.; Rajagopal, P.; Rosenow, W.; Anton, F.; Bodelon, C.; Chang-Claude, J.; Chenevix-Trench, G.; deFazio, A.; Doerk, T.; Ekici, A.; Ewing, A.; Fountzilas, G.; Goode, E.; Hartman, M.; Heitz, F.; Hillemanns, P.; Hogdall, E.; Hogdall, C.; Huzarski, T.; Jensen, A.; Karlan, B.; Khusnutdinova, E.; Kiemeney, L.; Kjaer, S.; Klapdor, R.; Kobel, M.; Li, J.; Liebrich, C.; May, T.; Olsson, H.; Permuth, J.; Peterlongo, P.; Radice, P.; Ramus, S.; Riggan, M.; Saloustros, E.; Simard, J.; Szafron, L.; Thompson, C.; Vierkant, R.; Winha
10.1101/2020.04.23.043653 — genetics — Posted on 2020-04-28
556 Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment
Peter, M. R.; Bilenky, M.; Isserlin, R.; Bader, G. D.; Shen, S. Y.; De Carvalho, D. D.; Hansen, A. R.; Hu, P.; Fleshner, N. E.; Joshua, A. M.; Hirst, M.; Bapat, B.
10.1101/2020.04.08.032565 — cancer biology — Posted on 2020-04-28
557 DeepArk: modeling cis-regulatory codes of model species with deep learning
Cofer, E. M.; Raimundo, J.; Tadych, A.; Yamazaki, Y.; Wong, A. K.; Theesfeld, C. L.; Levine, M. S.; Troyanskaya, O. G.
10.1101/2020.04.23.058040 — bioinformatics — Posted on 2020-04-28
558 Detecting and Quantitating Low Fraction DNA Variants with Low-Depth Sequencing
Song, P.; Chen, S. X.; Yan, Y. H.; Pinto, A.; Cheng, L. Y.; Dai, P.; Patel, A. A.; Zhang, D. Y.
10.1101/2020.04.26.061747 — bioengineering — Posted on 2020-04-28
562 Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality
Kanen, J. W.; Arntz, F. E.; Yellowlees, R.; Cardinal, R. N.; Price, A.; Christmas, D. M.; Apergis-Schoute, A. M.; Sahakian, B. J.; Robbins, T. W.
10.1101/789669 — neuroscience — Posted on 2020-04-28
563 Estimation of the number of synapses in the hippocampus and brain-wide by volume electron microscopy and genetic labeling
Santuy, A.; Tomas-Roca, L.; Rodriguez, J.-R.; Gonzalez-Soriano, J.; Zhu, F.; Qiu, Z.; Grant, S. G.; DeFelipe, J.; Merchan-Perez, A.
10.1101/2020.02.18.953802 — neuroscience — Posted on 2020-04-28
565 First detection of Infectious Spleen and kidney Necrosis Virus (ISKNV) associated with massive mortalities in farmed tilapia in Africa
Ramirez, G.; Paley, R. K.; Hunt, W.; Feist, S. W.; Stone, D. M.; Field, T.; Hayden, D.; Ziddah, P. A.; Nkansa, m.; Pecku, E. K.; Awuni, J. A.; Duodu, S.; Guilder, J.; Gray, J.; Wallis, T.; Verner-Jeffreys, D.
10.1101/680538 — microbiology — Posted on 2020-04-28
566 Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction
Ianiri, G.; Coelho, M. A.; Ruchti, F.; Sparber, F.; McMahon, T. J.; Fu, C.; Bolejack, M.; Donovan, O.; Smutney, H.; Myler, P.; Dietrich, F.; Fox, D.; LeibundGut-Landmann, S.; Heitman, J.
10.1101/2020.01.28.923367 — microbiology — Posted on 2020-04-28
571 Self-assembly of multi-component mitochondrial nucleoids via phase separation
Feric, M.; Demarest, T. G.; Tian, J.; Croteau, D. L.; Bohr, V. A.; Misteli, T.
10.1101/822858 — cell biology — Posted on 2020-04-28
572 Complementary α-arrestin - Rsp5 ubiquitin ligase complexes control selective nutrient transporter endocytosis in response to amino acid availability
Ivashov, V.; Zimmer, J.; Schwabl, S.; Kahlhofer, J.; Weys, S.; Gstir, R.; Jackschitz, T.; Kremser, L.; Bonn, G. K.; Lindner, H.; Huber, L. A.; LEON, S.; Schmidt, O.; Teis, D.
10.1101/2020.04.24.059832 — cell biology — Posted on 2020-04-28
573 Recombinant BCG overexpressing a STING agonist elicits trained immunity and improved antitumor efficacy in non-muscle invasive bladder
Singh, A. K.; Praharaj, M.; Lombardo, K. A.; Yoshida, T.; Matoso, A.; Baras, A. S.; Zhao, L.; Prasad, P.; Powell, J. D.; Kates, M.; McConkey, D.; Bishai, W.; Bivalacqua, T. J.
10.1101/2020.04.25.061531 — cancer biology — Posted on 2020-04-28
579 Remodeling of Chemotaxis is a Cornerstone of Bacterial Swarming
Partridge, J. D.; Nguyen, N. Q.; Dufour, Y. S.; Harshey, R. M.
10.1101/2020.04.27.064519 — microbiology — Posted on 2020-04-28
588 What does your cell really do? Model-based assessment of mammalian cells metabolic functionalities using omics data
Richelle, A.; Kellman, B. P.; Wenzel, A. T.; Chiang, A. W. T.; Reagan, T.; Gutierrez, J. M.; Joshi, C.; Li, S.; Liu, J. K.; Masson, H.; Lee, J.; Li, Z.; Heirendt, L.; Trefois, C.; Juarez, E. F.; Bath, T.; Borland, D.; Mesirov, J. P.; Robasky, K.; Lewis, N. E.
10.1101/2020.04.26.057943 — systems biology — Posted on 2020-04-28
591 Pharmacological Characterisation of Novel Adenosine Receptor A3R Antagonists
Barkan, K.; Lagarias, P.; Stampelou, M.; Stamatis, D.; Hoare, S.; Klotz, K.-N.; Vrontaki, E.; Kolocouris, A.; Ladds, G.
10.1101/693796 — pharmacology and toxicology — Posted on 2020-04-28
598 Deficiency in reverse cholesterol transport in mice augments sepsis
Wang, Q.; Guo, L.; Hao, D.; Ito, M.; Yu, K.-j.; Wang, R.-t.; Shaul, P.; Mineo, C.; Li, X.-a.
10.1101/2020.04.26.051250 — molecular biology — Posted on 2020-04-28
599 Rapid and sensitive direct detection and identification of poliovirus from stool and environmental surveillance samples using nanopore sequencing
Shaw, A. G.; Majumdar, M.; Troman, C.; O'Toole, A.; Benny, B.; Abraham, D.; Praharaj, I.; Kang, G.; Sharif, S.; Alam, M. M.; Shaukat, S.; Angez, M.; Khurshid, A.; Mahmood, N.; Arshad, Y.; Rehman, L.; Mujtaba, G.; Akthar, R.; Salman, M.; Klapsa, D.; Hajarha, Y.; Asghar, H.; Bandyopadhyay, A.; Rambaut, A.; Martin, J.; Grassly, N. C.
10.1101/2020.04.27.053421 — microbiology — Posted on 2020-04-28
601 Modulation of macrophage defense responses by Mycobacterial persistence protein MprA (Rv0981) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactions
Bhattacharyya, K.; Bandopadhyay, U.; Singh, A.; Prakash, A.; Nemaysh, V.; Jain, S.; Varma-Basil, M.; Lynn, A. M.; Bose, M.; Luthra, P. M.; Natarajan, K.; Brahmachari, V.
10.1101/2020.04.27.063602 — microbiology — Posted on 2020-04-28
602 Mycobacterium phage Butters-encoded proteins contribute to host defense against viral attack
Mageeney, C. M.; Mohammed, H. T.; Dies, M.; Anbari, S.; Cudkevich, N.; Chen, Y.; Buceta, J.; Ware, V. C.
10.1101/2020.04.27.053744 — microbiology — Posted on 2020-04-28
603 Systematic Discovery of Salmonella Phage-Host Interactions via High-Throughput Genome-Wide Screens
Adler, B. A.; Zhong, C.; Liu, H.; Kutter, E.; Deutschbauer, A. M.; Mutalik, V. K.; Arkin, A. P.
10.1101/2020.04.27.058388 — microbiology — Posted on 2020-04-28
605 The female urinary microbiota in relation to the reproductive tract microbiota
Chen, C.; Hao, L.; Wei, W.; Li, F.; Song, L.; Zhang, X.; Dai, J.; Jie, Z.; Li, J.; Song, X.; Wang, Z.; Zhang, Z.; Zeng, L.; Du, H.; Tang, H.; Yang, H.; Wang, J.; Kristiansen, K.; Xu, X.; Wu, R.; Jia, H.
10.1101/628974 — microbiology — Posted on 2020-04-28
608 Intraflagellar transport-A deficiency ameliorates ADPKD renal cystogenesis in a renal tubular- and maturation-dependent manner
Wang, W.; Silva, L.; Allard, B.; Pottorf, T.; Wang, H.; Jacobs, D.; Cornelius, J.; Chaturvedi, A.; Pritchard, M.; Sharma, M.; Wallace, D.; Calvet, J.; Tran, P.
10.1101/2020.04.26.061796 — genetics — Posted on 2020-04-28
610 Style transfer with variational autoencoders is a promising approach to RNA-Seq data harmonization and analysis
Russkikh, N. E.; Antonets, D. V.; Shtokalo, D. N.; Makarov, A. V.; Vyatkin, Y.; Zakharov, A. M.; Terentev, E. V.
10.1101/791962 — bioinformatics — Posted on 2020-04-28
612 In vitro Evolution of Antibody Affinity via Insertional Mutagenesis Scanning of an Entire Antibody Variable Region
Skamaki, K.; Emond, S.; Chodorge, M.; Andrews, J.; Rees, D. G.; Cannon, D.; Popovic, B.; Buchanan, A.; Minter, R.; Hollfelder, F.
10.1101/2020.04.26.062786 — biochemistry — Posted on 2020-04-28
615 Quantitative, super-resolution localization of small RNAs with sRNA-PAINT
Huang, K.; Demirci, F.; Batish, M.; Meyers, B. C.; Caplan, J. L.
10.1101/716696 — cell biology — Posted on 2020-04-28
617 A novel single-cell based method for breast cancer prognosis
Li, X.; Liu, L.; Goodall, G.; Schreiber, A. W.; Xu, T.; Li, J.; Le, T.
10.1101/2020.04.26.062794 — bioinformatics — Posted on 2020-04-28
619 Remote control of CAR T cell therapies by thermal targeting
Miller, I. C.; Sun, L.-K.; Harris, A. M.; Gamboa, L.; Zamat, A.; Kwong, G. A.
10.1101/2020.04.26.062703 — bioengineering — Posted on 2020-04-28
620 Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins
Piergentili, C.; Ross, J.; He, D.; Gallagher, K. J.; Stanley, W. A.; Adam, L.; Mackay, C. L.; Waldron, K. J.; Clarke, D. J.; Marles-Wright, J.
10.1101/785121 — biochemistry — Posted on 2020-04-28
622 Anaerobic microbial degradation of protein and lipid macromolecules in subarctic marine sediment
Pelikan, C.; Wasmund, K.; Glombitza, C.; Hausmann, B.; Herbold, C.; Flieder, M.; Loy, A.
10.1101/2020.04.27.061291 — microbiology — Posted on 2020-04-28
623 Lsr2 is a nucleoid-associated protein that exerts pleiotropic effects on mycobacterial cellular processes
Kolodziej, M.; Trojanowski, D.; Bury, K.; Holowka, J.; Pasciak, M.; Matysik, W.; Kakolewska, H.; Feddersen, H.; Giacomelli, G.; Bramkamp, M.; Konieczny, I.; Zakrzewska-Czerwinska, J.
10.1101/2020.04.27.063487 — microbiology — Posted on 2020-04-28
624 The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the Golgi during viral infections
Daussy, C. F.; Monard, S. C.; Guy, C.; Munoz-Gonzalez, S.; Chazal, M.; Anthonsen, M. W.; jouvenet, n.; Henry, T.; DREUX, M. -; Meurs, E. F.; Hansen, M. D.
10.1101/2020.04.27.063644 — microbiology — Posted on 2020-04-28
625 Inhibition of the NLRP3 inflammasome prevents ovarian aging
Navarro-Pando, J. M.; Alcocer-Gomez, E.; Castejon-Vega, B.; Muntane, J.; Wang, C.; Hoffman, H. M.; Sanz, A.; Mbalaviele, G.; Ryffel, B.; Cordero, M. D.
10.1101/2020.04.26.062646 — immunology — Posted on 2020-04-28
626 Generation of kidney ureteric bud and collecting duct organoids that recapitulate kidney branching morphogenesis
Zeng, Z.; Huang, B.; Parvez, R. K.; Li, Y.; Chen, J. H.; Vonk, A.; Thornton, M. E.; Patel, T.; Rutledge, E.; Kim, A. D.; Yu, J.; Pastor-Soler, N.; Hallows, K. R.; Grubbs, B. H.; McMahon, J. A.; McMahon, A. P.; Li, Z.
10.1101/2020.04.27.049031 — developmental biology — Posted on 2020-04-28
629 Spatial Transcriptional Mapping of the Human Nephrogenic Program
Lindstrom, N. O.; Sealfon, R.; Chen, X.; Parvez, R.; Ransick, A.; De Sena Brandine, G.; Guo, J.; Hill, B.; Tran, T.; Kim, A. D.; Zhou, J.; Tadych, A.; Watters, A.; Wong, A.; Lovero, E.; Grubbs, B.; Thornton, M.; Smith, A. D.; Ruffins, S. W.; Armit, C.; Troyanskaya, O. G.; McMahon, A. P.
10.1101/2020.04.27.060749 — cell biology — Posted on 2020-04-28
639 Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
V'kovski, P.; Steiner, S.; Gultom, M.; Kelly, J. N.; Russeil, J.; Mangeat, B.; Cora, E.; Pezoldt, J.; Holwerda, M.; Kratzel, A.; Laloli, L.; Wider, M.; Portmann, J.; Thao, T. T. N.; Ebert, N.; Stalder, H.; Hartmann, R.; Gardeux, V.; Alpern, D.; Deplancke, B.; Thiel, V.; Dijkman, R.
10.1101/2020.04.27.062315 — microbiology — Posted on 2020-04-27
640 Structure of replicating SARS-CoV-2 polymerase
Hillen, H. S.; Kokic, G.; Farnung, L.; Dienemann, C.; Tegunov, D.; Cramer, P.
10.1101/2020.04.27.063180 — biophysics — Posted on 2020-04-27
641 Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.
Pruijssers, A. J.; George, A. S.; Schäfer, A.; Leist, S. R.; Gralinski, L. E.; Dinnon, K. H.; Yount, B. L.; Agostini, M. L.; Stevens, L. J.; Chappell, J. D.; Lu, X.; Hughes, T. M.; Gully, K. L.; Martinez, D. R.; Brown, A. J.; Graham, R. L.; Perry, J. K.; Du Pont, V.; Pitts, J.; Ma, B.; Babusis, D.; Murakami, E.; Feng, J. Y.; Bilello, J. P.; Porter, D. P.; Cihlar, T.; Baric, R. S.; Denison, M. R.; Sheahan, T. P.
10.1101/2020.04.27.064279 — microbiology — Posted on 2020-04-27
642 LncRNA s Landscape in the patients of primary gout by Microarray Analysis
Qing, Y.-F.; Zheng, J.-X.; Tang, Y.-P.; Dong, Z.-R.; Dai, F.; Zhang, Q.-B.
10.1101/2020.04.27.063768 — genetics — Posted on 2020-04-27
643 A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains
Dearlove, B. L.; Lewitus, E.; Bai, H.; Li, Y.; Reeves, D. B.; Joyce, M. G.; Scott, P.; Amare, M.; Vasan, S.; Michael, N. L.; Modjarrad, K.; Rolland, M.
10.1101/2020.04.27.064774 — evolutionary biology — Posted on 2020-04-27
644 Forest canopy cover composition and landscape influence over bryophytes communities in Nothofagus forests of southern Patagonia
Toro Manriquez, M. D.; Ardiles, V.; Promis, A.; Huertas Herrera, A.; Soler, R.; Lencinas, M. V.; Martinez Pastur, G.
10.1101/2020.04.27.063826 — ecology — Posted on 2020-04-27
648 Neuroendocrine mechanisms governing sex-differences in chronic pain involve prolactin receptor sensory neuron signaling
Paige, C.; Barba-Escobedo, P. A.; Mecklenburg, J.; Patil, M.; Goffin, V.; Grattan, D.; Dussor, G.; Akopian, A. N.; Price, T. J.
10.1101/2020.04.25.061663 — neuroscience — Posted on 2020-04-27
649 An automated homecage system for multiwhisker detection and discrimination learning in mice
Bernhard, S. M.; Lee, J.; Zhu, M.; Hsu, A.; Erskine, A.; Hires, S. A.; Barth, A. L.
10.1101/2020.04.27.063750 — neuroscience — Posted on 2020-04-27
655 Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain
El Kodsi, D. N.; Tokarew, J. M.; Sengupta, R.; Lengacher, N. A.; Ng, A. C.; Boston, H.; Jiang, Q.; Palmberg, C.; Pileggi, C.; Shutinoski, B.; Li, J.; Nguyen, A. P.; Fehr, T. K.; Im, D. S.; Callaghan, S.; Park, D. S.; LaVoie, M. J.; Chan, J. A.; Takanashi, M.; Hattori, N.; Ratan, R. R.; Zecca, L.; Puente, L.; Shaw, G. S.; Harper, M.-E.; Holmgren, A.; Tomlinson, J. J.; Schlossmacher, M. G.
10.1101/2020.04.26.062380 — neuroscience — Posted on 2020-04-27
656 Toward Minimally Invasive Therapeutic Ultrasound: Ultrasound-guided Ablation in Neuro-oncology
Belzberg, M.; Mahapatra, S.; Chavez, F.; Morrison, K.; Xiong, K. T.; Gamo, N. J.; Restaino, S.; Iyer, R. R.; Groves, M.; Thakor, N.; Theodore, N.; Luciano, M. G.; Brem, H.; Cohen, A. R.; Manbachi, A.
10.1101/2020.04.25.061788 — bioengineering — Posted on 2020-04-27
658 Sensory and motor electrophysiological mapping of the cerebellum in humans.
Ashida, R.; Walsh, P.; Brooks, J. C. W.; Edwards, R. J.; Cerminara, N. L.; Apps, R.
10.1101/2020.04.25.061044 — neuroscience — Posted on 2020-04-27
659 Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans
Kanen, J. W.; Apergis-Schoute, A. M.; Yellowlees, R.; Arntz, F. E.; van der Flier, F. E.; Price, A.; Cardinal, R. N.; Christmas, D. M.; Clark, L.; Sahakian, B. J.; Crockett, M. J.; Robbins, T. W.
10.1101/2020.04.26.062463 — neuroscience — Posted on 2020-04-27
661 Upper extremity exomuscle for shoulder abduction support
Simpson, C.; Huerta, B.; Sketch, S.; Lansberg, M.; Hawkes, E.; Okamura, A.
10.1101/2020.04.25.061846 — bioengineering — Posted on 2020-04-27
662 NMR microsystem for label-free characterization of 3D nanoliter microtissues
Grisi, M.; Conley, G. M.; Rodriguez, K. J.; Riva, E.; Egli, L.; Moritz, W.; Lichtenberg, J.; Brugger, J.; Boero, G.
10.1101/2020.04.26.062141 — bioengineering — Posted on 2020-04-27
665 Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands
Swovick, K.; Firsanov, D.; Welle, K. A.; Hryhorenko, J. R.; Wise, J. P.; George, C.; Sformo, T.; Seluanov, A.; Gorbunova, V.; Ghaemmaghami, S.
10.1101/2020.04.25.061150 — systems biology — Posted on 2020-04-27
666 Repurposing Pyramax for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate
Lane, T. R.; Dyall, J.; Mercer, L.; Goodin, C.; Foil, D. H.; Zhou, H.; Postnikova, E.; Liang, J. Y.; Holbrook, M.; Madrid, P.; Ekins, S.
10.1101/2020.04.25.061333 — pharmacology and toxicology — Posted on 2020-04-27
671 Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty
Kanen, J. W.; Arntz, F. E.; Yellowlees, R.; Christmas, D. M.; Price, A.; Apergis-Schoute, A. M.; Sahakian, B. J.; Cardinal, R. N.; Robbins, T. W.
10.1101/2020.04.26.062505 — neuroscience — Posted on 2020-04-27
672 An alternative model to prion fragmentation based on the detailed balance between PrPSc and suPrP
Chyba, M.; Kotas, J.; Beringue, V.; Eblen, C.; Igel-Egalon, A.; Kravchenko, Y.; Rezaei, H.
10.1101/2020.04.24.058917 — neuroscience — Posted on 2020-04-27
674 Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage
Amen, A. M.; Fellmann, C.; Soczek, K. M.; Ren, S. M.; Lew, R. J.; Knott, G. J.; Park, J. E.; McKinney, A. M.; Mancini, A.; Doudna, J. A.; Costello, J. F.
10.1101/2020.04.25.061606 — cancer biology — Posted on 2020-04-27
679 DNA Methylation-based Signatures Classify Sporadic Pituitary Tumors According to Clinicopathological Features.
Mosella, M. S.; Sabedot, T. S.; Silva, T. C.; Malta, T. M.; Segato, F. D.; Asmaro, K. P.; Wells, M.; Mukherjee, A.; Poisson, L. M.; Snyder, J.; deCarvalho, A. C.; Walbert, T.; Aho, T.; Kalkanis, S.; Elias, P. C.; Antonini, S. R.; Rock, J.; Noushmehr, H.; Castro, M.; Castro, A. V.
10.1101/2020.04.25.061903 — cancer biology — Posted on 2020-04-27
680 The Injury Response to DNA Damage Promotes Anti-Tumor Immunity
Sriram, G.; Milling, L. E.; Chen, J.-K.; Abraham, W.; Handly, E. D.; Irvine, D. J.; Yaffe, M. B.
10.1101/2020.04.26.062216 — cancer biology — Posted on 2020-04-27
681 Embedded Enzyme Nanoclusters Depolymerize Polyesters via Chain-End Mediated Processive Degradation
DelRe, C.; Kwon, J.; Kang, P.; Ma, L.; Hall, A.; Ruan, Z.; Zolkin, K.; Li, T.; Ritchie, R. O.; Xu, T.
10.1101/2020.04.25.052050 — bioengineering — Posted on 2020-04-27
683 Molecular Characterization of Depression Trait and State
Shukla, R.; Sibille, E.; Newton, D.; Sumitomo, A.; Zare, H.; Mccullumsmith, R.; Lewis, D.; Tomoda, T.
10.1101/2020.04.24.058610 — neuroscience — Posted on 2020-04-27
684 Metagenomic survey unravel diversity of biogas microbiome with potential to enhance its' productivity in Kenya
Muturi, S. M.; Muthui, L. W.; Njogu, P. M.; Onguso, J. M.; Wachira, F. N.; Opiyo, S. O.; Pelle, R.
10.1101/2020.04.23.048504 — biochemistry — Posted on 2020-04-27
686 Detection of epistasis between ACTN3 and SNAP-25 with an insight towards gymnastic aptitude identification
Płociennik, Łukasz A.; Zaucha, J.; Zaucha, J. M.; Łukaszuk, K.; Jozwicki, M.; Płociennik, M.; Cieszczyk, P.
10.1101/2020.04.25.060020 — genetics — Posted on 2020-04-27
687 Gain of gene regulatory network interconnectivity at the origin of vertebrates
Gil-Galvez, A.; Jimenez-Gancedo, S.; Acemel, R. D.; Bertrand, S.; Schubert, M.; Escriva, H.; Tena, J. J.; Gomez-Skarmeta, J. L.
10.1101/2020.04.25.061077 — evolutionary biology — Posted on 2020-04-27
691 In-silico studies of Riparin B in the design of drugs: Physicochemical, pharmacokinetic and pharmacodynamic parameters
Rodrigues, A. M. X.; Oliveira, A. P. d.; Costa, R. K. M.; Machado, R. S.; Gutierrez, S. J. C.; Lima, F. d. C. A.
10.1101/2020.04.24.059626 — bioinformatics — Posted on 2020-04-27
694 In silico Identification and Functional Characterization of Conserved miRNAs in Fibre Biogenesis Crop Corchorus capsularis
Hasan, M.; Ahmed, M.; Ahmed, F.; Ahmed, J.; Akhand, M. R. N.; Azim, K. F.; Imran, M. A. S.; Hoque, S. F.
10.1101/2020.04.22.056176 — genomics — Posted on 2020-04-27
695 Genome-wide association analysis reveals new insights into the genetic architecture of defensive, agro-morphological and quality-related traits in cassava
Rabbi, I. Y.; Kayondo, S. I.; Bauchet, G.; Muyideen, Y.; Aghogho, C. I.; Ogunpaimo, K.; Uwugiaren, R.; Ikpan, A. S.; Peteti, P.; Agbona, A.; Parkes, E.; Ezenwaka, L.; Wolfe, M.; Jannink, J.-L.; Egesi, C.; Kulakow, P.
10.1101/2020.04.25.061440 — genetics — Posted on 2020-04-27
697 Polycationic gold nanorods as multipurpose in vitro microtubule markers
Wedler, V.; Strauss, F.; Sudhakar, S.; Hermsdorf, G. L.; Stierhof, Y.-D.; Schäffer, E.
10.1101/2020.04.25.061127 — biophysics — Posted on 2020-04-27
699 Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp
Montnach, J.; Lorenzini, M.; Lesage, A.; Simon, I.; Nicolas, S.; Moreau, E.; Marionneau, C.; Baro, I.; De Waard, M.; Loussouarn, G.
10.1101/2020.04.27.062182 — biophysics — Posted on 2020-04-27
702 Natural selection imposed by mechanical properties of a biomaterial results in novel cellular phenotypes
Purkayastha, P.; Pendyala, K.; Saxena, A. S.; Hakimjavadi, H.; Chamala, S.; Baer, C. F.; Lele, T. P.
10.1101/2020.04.26.061911 — evolutionary biology — Posted on 2020-04-27
704 Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
Di Giorgio, S.; Martignano, F.; Torcia, M. G.; Mattiuz, G.; Conticello, S. G.
10.1101/2020.03.02.973255 — bioinformatics — Posted on 2020-04-27
705 Automated platform for high-throughput screening of base-modified aptamers for affinity and specificity
Wu, D.; Feagin, T.; Mage, P.; Rangel, A.; Wan, L.; Li, A.; Coller, J.; Eisenstein, M.; Pitteri, S.; Soh, H. T.
10.1101/2020.04.25.060004 — bioengineering — Posted on 2020-04-27
706 bak1-5 mutation uncouples tryptophan-dependent and independent postinvasive immune pathways triggered in Arabidopsis by multiple fungal pathogens
Kosaka, A.; Pastorczyk, M.; Pislewska-Bednarek, M.; Nishiuchi, T.; Suemoto, H.; Ishikawa, A.; Frerigmann, H.; Kaido, M.; Mise, K.; Bednarek, P.; Takano, Y.
10.1101/2020.04.26.052480 — plant biology — Posted on 2020-04-27
708 Genome-wide identification and transcriptional analyses of MATE transporter genes in root tips of wild Cicer spp. under aluminium stress
Zhang, X.; Weir, B.; Wei, H.; Deng, Z.; Zhang, X.-Q.; Zhang, Y.; Xu, X.; Zhao, C.; Berger, J. D.; Vance, W. H.; Bell, R. W.; JIA, Y.; Li, C.
10.1101/2020.04.27.063065 — plant biology — Posted on 2020-04-27
709 Reproductive phasiRNA loci and DICER-LIKE5, but not microRNA loci, diversified in monocotyledonous plants
Patel, P.; Mathioni, S. M.; Hammond, R.; Harkess, A. E.; Kakrana, A.; Arikit, S.; Dusia, A.; Meyers, B. C.
10.1101/2020.04.25.061721 — plant biology — Posted on 2020-04-27
711 Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals Broad Potential Host Range of SARS-CoV-2
Liu, Y.; Hu, G.; Wang, Y.; Zhao, X.; Ji, F.; Ren, W.; Gong, M.; Ju, X.; Li, C.; Hong, J.; Zhu, Y.; Cai, X.; Wu, J.; Lan, X.; Xie, Y.; Wang, X.; Yuan, Z.; Zhang, R.; Ding, Q.
10.1101/2020.04.22.046565 — microbiology — Posted on 2020-04-27
712 A draft genome of grass pea (Lathyrus sativus), a resilient diploid legume
Emmrich, P. M. F.; Sarkar, A.; Njaci, I.; Kaithakottil, G. G.; Ellis, N.; Moore, C.; Edwards, A.; Heavens, D.; Waite, D.; Cheema, J.; Trick, M.; Moore, J.; Webb, A.; Calazzo, R.; Thomas, J.; Higgins, J.; Swarbreck, D.; Kumar, S.; Mundree, S.; Loose, M. W.; Yant, L.; Martin, C.; Wang, T. L.
10.1101/2020.04.24.058164 — genomics — Posted on 2020-04-27
714 An integrated mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons.
Ma, Q.; Srivastav, S. P.; Gamez, S.; Feitosa-Suntheimer, F.; Patterson, E. I.; Johnson, R.; Matson, E.; Gold, A.; Brackney, D.; Connor, J.; Colpitts, T.; Hughes, G.; Rasgon, J.; Nolan, T.; Akbari, O. S.; Lau, N.
10.1101/2020.04.25.061598 — genomics — Posted on 2020-04-27
716 A GTP-state specific cyclic peptide inhibitor of the GTPase Gαs
Dai, S. A.; Hu, Q.; Gao, R.; Lazar, A.; Zhang, Z.; von Zastrow, M.; Suga, H.; Shokat, K. M.
10.1101/2020.04.25.054080 — biochemistry — Posted on 2020-04-27
721 Endocrine signaling mediates asymmetric motor deficits after unilateral brain injury
Lukoyanov, N.; Watanabe, H.; Carvalho, L.; Kononenko, O.; Sarkisyan, D.; Zhang, M.; Andersen, M. S.; Lukoyanova, E. A.; Galatenko, V.; Tonevitsky, A. G.; Bazov, I.; Iakovleva, T.; Schouenborg, J.; Bakalkin, G.
10.1101/2020.04.23.056937 — neuroscience — Posted on 2020-04-27
723 Alpha-synuclein expression supports interferon stimulated gene expression in neurons
Massey, A. R.; Monogue, B.; Chen, Y.; Lesteberg, K.; Johnson, M. E.; Bergkvist, L.; Steiner, J.; Ma, J.; Mahalingam, R.; Kleinschmidt-Demasters, B. K.; Escobar Galvis, M.; Brundin, P.; Kunath, T.; Beckham, J. D.
10.1101/2020.04.25.061762 — neuroscience — Posted on 2020-04-27
725 Novel Immunoassay for Diagnosis of Ongoing Clostridioides difficile Infections Using Serum and Medium Enriched for Newly Synthesized Antibodies (MENSA)
Haddad, N. S.; Nozick, S.; Kim, G.; Ohanian, S.; Kraft, C. S.; Rebolledo, P. A.; Wang, Y. F.; Wu, H.; Bressler, A.; Le, S. N. T.; Kuruvilla, M. E.; Cannon, L. E.; Lee, F. E.-H.; Daiss, J.
10.1101/2020.04.23.058859 — microbiology — Posted on 2020-04-27
727 Phytochrome mediated responses in Agrobacterium fabrum: growth, swimming, plant infection and interbacterial competition
Xue, P.; Bai, Y.; Rottwinkel, G.; Averbukh, E.; Ma, Y.; Roeder, T.; Scheerer, P.; Krauss, N.; Lamparter, T.
10.1101/2020.04.24.060905 — microbiology — Posted on 2020-04-27
728 Conformational Tuning of Amylin by Charged SMA Copolymers
Sahoo, B.; Souders, C.; Ivanova, M.; Deng, Z.; Nakayama, T.; Suladze, S.; Reif, B.; Ando, T.; Martyniuk, C.; Ramamoorthy, A.
10.1101/2020.04.23.057547 — biophysics — Posted on 2020-04-27
733 Dynamics of Brain Structure and its Genetic Architecture over the Lifespan
Brouwer, R. M.; Klein, M.; Grasby, K. L.; Schnack, H. G.; Jahanshad, N.; Teeuw, J.; Thomopoulos, S. I.; Sprooten, E.; Franz, C. E.; Gogtay, N.; Kremen, W.; Panizzon, M. S.; Olde Loohuis, L. M.; Whelan, C. D.; Aghajani, M.; Alloza, C.; Alnaes, D.; Artiges, E.; Ayesa-Arriola, R.; Barker, G. J.; Blok, E.; Boen, E.; Breukelaar, I. A.; Bright, J. K.; Buimer, E. E.; Bülow, R.; Cannon, D. M.; Ciufolini, S.; Crossley, N. A.; Damatac, C. G.; Dazzan, P.; de Mol, C. L.; de Zwarte, S. M.; Desrivieres, S.; Diaz-Caneja, C. M.; Doan, N. T.; Dohm, K.; Fröhner, J. H.; Goltermann, J.; Grigis, A.; Grotegerd, D
10.1101/2020.04.24.031138 — genetics — Posted on 2020-04-27
735 Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood
Skead, K.; Ang Houle, A.; Abelson, S.; Agbessi, M.; Bruat, V.; Lin, B.; Soave, D.; Shlush, L.; Wright, S.; Dick, J.; Morris, Q.; Awadalla, P.
10.1101/2020.04.25.058677 — cancer biology — Posted on 2020-04-27
738 Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19
Zhang, B.-z.; Hu, Y.-f.; Chen, L.-l.; Tong, Y.-g.; Hu, J.-c.; Cai, J.-p.; Chan, K.-H.; Dou, Y.; Deng, J.; Gong, H.-r.; Kuwentrai, C.; Li, W.; Wang, X.-l.; Chu, H.; Su, C.-h.; Hung, I. F.-N.; Yau, T. C. C.; To, K. K.-W.; Yuen, K. Y.; Huang, J.-D.
10.1101/2020.04.23.056853 — microbiology — Posted on 2020-04-27
740 Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients.
Furner-Pardoe, J.; Anonye, B. O.; Cain, R.; Moat, J.; Ortori, C. A.; Lee, C.; Barrett, D. A.; Corre, C.; Harrison, F.
10.1101/2020.04.21.052522 — microbiology — Posted on 2020-04-27
741 Genetic population structure constrains local adaptation and probability of parallel evolution in sticklebacks
Kemppainen, P. M.; Li, Z.; Rastas, P.; Loytynoja, A.; Fang, B.; Guo, B.; Shikano, T.; Yang, J.; Merila, J.
10.1101/2020.01.17.908970 — evolutionary biology — Posted on 2020-04-27
743 Formation of mechanical interfaces by self-organized Toll-8/Cirl GPCR asymmetry
Lavalou, J.; Mao, Q.; Harmansa, S.; Kerridge, S.; Lellouch, A. C.; Philippe, J.-M.; Audebert, S.; Camoin, L.; Lecuit, T.
10.1101/2020.03.16.993758 — developmental biology — Posted on 2020-04-27
748 Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion
Burns, C. H.; Yau, B.; Rodriguez, A.; Triplett, J. D.; Maslar, D.; An, Y. S.; van der Welle, R. E. N.; Kossina, R. G.; Fisher, M. R.; Strout, G. W.; Bayguinov, P. O.; Veenendaal, T.; Chitayat, D.; Fitzpatrick, J. A. J.; Klumperman, J.; Kebede, M. A.; Asensio, C. S.
10.1101/2020.04.25.043729 — physiology — Posted on 2020-04-26
749 The crystal structure of nsp10-nsp16 heterodimer from SARS CoV-2 in complex with S-adenosylmethionine
Rosas Lemus, M.; Minasov, G.; Shuvalova, L.; Inniss, N. L.; Kiryukhina, O.; Wiersum, G.; Kim, Y.; Jedrzejczak, R.; Maltseva, N. I.; Endres, M.; Jaroszewski, L.; Godzik, A.; Joachimiak, A.; Satchell, K. J.
10.1101/2020.04.17.047498 — biochemistry — Posted on 2020-04-26
751 Oxidised phosphatidylcholines induce multiple functional defects in airway epithelial cells
Pascoe, C. D.; Roy, N.; Turner-Brannen, E.; Schultz, A.; Ravandi, A.; Halayko, A. J.; West, A. R.
10.1101/823666 — cell biology — Posted on 2020-04-26
755 Chemical, physical and biological factors triggering Bcl-xL-mediated apoptosis
Ianevski, A.; Kulesskiy, E.; Krpina, K.; Lou, G.; Aman, Y.; Bugai, A.; Aasumets, K.; Akimov, Y.; Bulanova, D.; Gildemann, K.; Arutyunyan, A. F.; Susova, O. Y.; Zhuze, A. L.; Ji, P.; Wang, W.; Zusinaite, E.; Oksenych, V.; Lysvand, H.; Gerhold, J.; Bjoras, M.; Waage, A.; Johansen, P.; Heckman, C.; Fang, E. F.; Kainov, D. E.
10.1101/2020.01.13.904714 — cancer biology — Posted on 2020-04-26
756 Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance
Kovacs, A.; Vermeer, D. W.; Madeo, M.; Reavis, H.; Vermeer, S. J.; Williamson, C. S.; Rickel, A.; Stamp, J.; Lucido, C. T.; Cain, J.; Bell, M.; Morgan, M.; Yoon, J.-Y.; Mitchell, M. A.; Tulina, N.; Stuckelberger, S.; Budina, A.; Orman, D.; Jung, E.; Schwartz, L. E.; Eichwald, T.; Hong, Z.; Weimer, J.; Hooper, J. E.; Godwin, A. K.; Talbot, S.; Drapkin, R.; Vermeer, P. D.
10.1101/2020.04.24.058594 — cancer biology — Posted on 2020-04-26
757 Detecting sample swaps in diverse NGS data types using linkage disequilibrium
Javed, N. M.; Farjoun, Y.; Fennell, T.; Epstein, C. B.; Bernstein, B. E.; Shoresh, N.
10.1101/2020.03.15.992750 — bioinformatics — Posted on 2020-04-26
759 Pangenome analytics reveal two-component systems as conserved targets in ESKAPEE pathogens
Rajput, A.; Seif, Y.; Choudhary, K. S.; Dalldorf, C.; Poudel, S.; Monk, J.; Palsson, B. O.
10.1101/2020.04.25.061994 — microbiology — Posted on 2020-04-26
760 How did SARS-CoV-19 spread in India from Italy, Iran and China? Genetic surveillance of early cases and virus demography
Thakur, M.; Singh, A.; Joshi, B. D.; Ghosh, A.; Singh, S. K.; Singh, N.; Sharma, L. K.; Chandra, K.
10.1101/2020.04.26.062406 — genomics — Posted on 2020-04-26
761 Chromosomal Mcm2-7 distribution is the primary driver of the genome replication program in species from yeast to humans
Foss, E. J.; Sripathy, S.; Gatobonton-Schwager, T.; Kwak, H.; Thiesen, A. H.; Lao, U.; Bedalov, A.
10.1101/737742 — genetics — Posted on 2020-04-26
762 Regulatory control circuits for stabilizing long-term anabolic product formation in yeast
D'Ambrosio, V.; Dore, E.; Di Blasi, R.; Broek, M. v. d.; Sudarsan, S.; Horst, J. t.; Ambri, F.; Sommer, M. O. A.; Rugbjerg, P.; Keasling, J. D.; Mans, R.; Jensen, M. K.
10.1101/2020.04.26.062273 — synthetic biology — Posted on 2020-04-26
766 Heterologous production of 1-tuberculosinyladenosine in Mycobacterium kansasii models pathoevolution towards the transcellular lifestyle of Mycobacterium tuberculosis.
Ghanem, M.; Dube, J.-Y.; Wang, J.; McIntosh, F.; Houle, D.; Domenech, P.; Reed, M. B.; Raman, S.; Buter, J.; Minnaard, A. J.; Moody, B.; Behr, M. A.
10.1101/2020.04.25.060590 — microbiology — Posted on 2020-04-26
768 A putative genomic map for resistance of Bos indicus cattle in Cameroon to bovine tuberculosis
Callaby, R.; Kelly, R. F.; Mazeri, S.; Egbe, F.; Benedictus, L.; Clark, E. L.; Doeschl-Wilson, A.; Bronsvoort, B. M. d. C.; Salavati, M.; Muwonge, A.
10.1101/2020.04.26.057497 — genetics — Posted on 2020-04-26
770 Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect
Green, R.; Sonal, S.; Lu, W.; Wang, L.; Hart, S. F.; Skelding, D.; Burton, J. C.; Capel, A.; Chen, H. A.; Lin, A.; Subramaniam, A. R.; Rabinowitz, J. D.; Shou, W.
10.1101/498543 — evolutionary biology — Posted on 2020-04-26
771 CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways
Li, B.; Zheng, L.-S.; Zhang, C.-M.; Huang, Q.-J.; Guo, Y.-H.; Wang, L.-Q.; Yu, P.; Liu, S.-R.; Lin, Q.; Luo, Y.-X.; Zhou, H.; Yang, J.-H.; Qu, L.-H.
10.1101/2020.04.24.059162 — cell biology — Posted on 2020-04-26
772 Structural Basis of RNA Cap Modification by SARS-CoV-2 Coronavirus
Viswanathan, T.; Arya, S.; Chan, S.-H.; Qi, S.; Dai, N.; Hromas, R. A.; Park, J.-G.; Oladunni, F.; Martinez-Sobrido, L.; Gupta, Y. K.
10.1101/2020.04.26.061705 — biophysics — Posted on 2020-04-26
775 Propagation of THz irradiation energy through aqueous layers: Demolition of actin filaments in living cells
Yamazaki, S.; Harata, M.; Ueno, Y.; Tsubouchi, M.; Konagaya, K.; Ogawa, Y.; Isoyama, G.; Otani, C.; Hoshina, H.
10.1101/846295 — cell biology — Posted on 2020-04-26
779 Increasing the resolution and precision of psychiatric GWAS by re-imputing summary statistics using a large, diverse reference panel
Chatzinakos, C.; Lee, D.; Na, C.; Vladimirov, V.; Webb, B. T.; Riley, B.; Flint, J.; Kendler, K.; Ressler, K. J.; Daskalakis, N. P.; Bacanu, S.-A.
10.1101/496570 — bioinformatics — Posted on 2020-04-26
783 Thermal stratification and fish thermal preference explain vertical eDNA distributions in lakes
Littlefair, J. E.; Hrenchuk, L. E.; Blanchfield, P. J.; Rennie, M. D.; Cristescu, M. E.
10.1101/2020.04.21.042820 — ecology — Posted on 2020-04-26
785 Chromosome-level and haplotype-resolved genome assembly enabled by high-throughput single-cell sequencing of gamete genomes
Campoy, J. A.; Sun, H.; Goel, M.; Jiao, W.-B.; Folz-Donahue, K.; Kukat, C.; Rubio, M.; Ruiz, D.; Huettel, B.; Schneeberger, K.
10.1101/2020.04.24.060046 — genomics — Posted on 2020-04-26
789 Recombinant BCG overexpressing a STING agonist elicits trained immunity and improved antitumor efficacy in non-muscle invasive bladder
Singh, A. K. K.; Praharaj, M.; Lombardo, K. A.; Yoshida, T.; Matoso, A.; Baras, A. S.; Zhao, L.; Prasad, P.; Powell, J. D.; Kates, M.; McConkey, D.; Bivalacqua, T. J.; Bishai, W.
10.1101/2020.04.25.061531 — cancer biology — Posted on 2020-04-25
793 Binding specificities of human RNA binding proteins towards structured and linear RNA sequences
Jolma, A.; Zhang, J.; Mondragon, E.; Morgunova, E.; Kivioja, T.; Laverty, K. U.; Yin, Y.; Zhu, F.; Bourenkov, G.; Morris, Q.; Hughes, T. R.; Maher, L. J.; Taipale, J.
10.1101/317909 — systems biology — Posted on 2020-04-25
794 Imaging cell lineage with a synthetic digital recording system
Chow, K.-H. K.; Budde, M. W.; Granados, A. A.; Cabrera, M.; Yoon, S.; Cho, S.; Huang, T.-h.; Koulena, N.; Frieda, K. L.; Cai, L.; Lois, C.; Elowitz, M. B.
10.1101/2020.02.21.958678 — synthetic biology — Posted on 2020-04-25
799 Validation of a SARS-CoV-2 spike ELISA for use in contact investigations and serosurveillance
Freeman, B.; Lester, S.; Mills, L.; Rasheed, M. A. U.; Moye, S.; Abiona, O.; Hutchinson, G.; Morales-Betoulle, M.; Krapinunaya, I.; Gibbons, A.; Chiang, C.-F.; Cannon, D.; Klena, J.; Johnson, J. A.; Owen, S. M.; Graham, B. S.; Corbett, K. S.; Thornburg, N. J.
10.1101/2020.04.24.057323 — immunology — Posted on 2020-04-25
803 Chromosome-scale de novo diploid assembly of the apple cultivar 'Gala Galaxy'
Broggini, G. A. L.; Schlathölter, I.; Russo, G.; Copetti, D.; Yates, S. A.; Studer, B.; Patocchi, A.
10.1101/2020.04.25.058891 — genomics — Posted on 2020-04-25
804 Comparative Analysis of Gut Microbiome in Individuals of the Old Civilization of Caral-Supe Based on Data from 16S rRNA and ITS region
Vasquez-Dominguez, A.; Jaramillo-Valverde, L.; Levano, K. S.; Novoa-Bellota, P.; Machaguay-Romero, M.; Shady Solis, R.; Guio, H.
10.1101/2020.04.24.060582 — genetics — Posted on 2020-04-25
808 A rapid, low cost, and highly sensitive SARS-CoV-2 diagnostic based on whole genome sequencing
Glenn St Hilaire, B.; Durand, N. C.; Mitra, N.; Godinez Pulido, S.; Mahajan, R.; Blackburn, A.; Colaric, Z. L.; Theisen, J. W. M.; Weisz, D.; Dudchenko, O.; Gnirke, A.; Rao, S.; Kaur, P.; Aiden, E. L.; Aiden, A. P.
10.1101/2020.04.25.061499 — genomics — Posted on 2020-04-25
810 Northstar enables automatic classification of known and novel cell types from tumor samples
Zanini, F.; Berghuis, B. A.; Jones, R. C.; Nicolis di Robilant, B.; Nong, R. Y.; Norton, J.; Clarke, M. F.; Quake, S. R.
10.1101/820928 — bioinformatics — Posted on 2020-04-25
811 SARS-CoV-2 Productively Infects Human Gut Enterocytes
Lamers, M. M.; Beumer, J.; van der Vaart, J.; Knoops, K.; Puschhof, J.; Breugem, T. I.; Ravelli, R. B. G.; van Schayck, J. P.; Mykytyn, A. Z.; Duimel, H. Q.; van Donselaar, E.; Riesebosch, S.; Kuijpers, H. J. H.; Schipper, D.; van de Wetering, W. J.; de Graaf, M.; Koopmans, M.; Cuppen, E.; Peters, P. J.; Haagmans, B. L.; Clevers, H.
10.1101/2020.04.25.060350 — cell biology — Posted on 2020-04-25
814 KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia
Au, Y. Z.; Gu, M.; De Braekeleer, E.; Yu, J. S. L.; Ong, S. H.; Gozdecka, M.; Chen, X.; Tzelepis, K.; Huntly, B. J. P.; Vassiliou, G. S.; Yusa, K.
10.1101/2020.04.25.054049 — cancer biology — Posted on 2020-04-25
815 An adjunctive therapy approach prevents antibiotic resistance emergence in opportunistic pathogens colonizing the gut
Morley, V. J.; Kinnear, C. L.; Sim, D. G.; Olson, S. N.; Jackson, L. M.; Hansen, E.; Usher, G. A.; Showalter, S. A.; Pai, M. P.; Woods, R. J.; Read, A. F.
10.1101/2020.04.24.059444 — evolutionary biology — Posted on 2020-04-25
823 Optimized qRT-PCR approach for the detection of intra- and extracellular SARS-CoV-2 RNAs
Toptan, T.; Hoehl, S.; Westhaus, S.; Bojkova, D.; Berger, A.; Rotter, B.; Hoffmeier, K.; Ciesek, S.; Widera, M.
10.1101/2020.04.20.052258 — microbiology — Posted on 2020-04-25
824 Rapid SARS-CoV-2 whole genome sequencing for informed public health decision making in the Netherlands
Oude Munnink, B. B.; Nieuwenhuijse, D. F.; Stein, M.; O'Toole, A.; Haverkarte, M.; Mollers, M.; Kamga, S. K.; Schapendonk, C.; Lexmond, P.; Pronk, M.; van der Linden, A.; Bestebroer, T.; Chestakova, I.; Overmars, R. J.; van Nieuwkoop, S.; Molenkamp, R.; van der Eijck, A.; GeurtsvanKessel, C.; Vennema, H.; Meijer, A.; Rambaut, A.; van Dissel, J.; Sikkema, R.; Timen, A.; Koopmans, M.
10.1101/2020.04.21.050633 — genomics — Posted on 2020-04-25
825 MINERVA: A facile strategy for SARS-CoV-2 whole genome deep sequencing of clinical samples
Chen, C.; Li, J.; Di, L.; Jing, Q.; Du, P.; Song, C.; Li, J.; Li, Q.; Cao, Y.; Xie, S.; Wu, A. R.; Zeng, H.; Huang, Y.; Wang, J.
10.1101/2020.04.25.060947 — molecular biology — Posted on 2020-04-25
830 Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients
McKay, P. F.; Hu, K.; Blakney, A. K.; Samnuan, K.; Bouton, C. R.; Rogers, P.; Polra, K.; Lin, P. J. C.; Barbosa, C.; Tam, Y.; Shattock, R. J.
10.1101/2020.04.22.055608 — immunology — Posted on 2020-04-25
834 Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine
Golebiewska, A.; Hau, A.-C.; Oudin, A.; Stieber, D.; Yabo, Y. A.; Baus, V.; Barthelemy, V.; Klein, E.; Bougnaud, S.; Keunen, O.; Wantz, M.; Michelucci, A.; Neirinckx, V.; Muller, A.; Kaoma, T.; Nazarov, P. V.; Azuaje, F.; De Falco, A.; Flies, B.; Richart, L.; Poovathingal, S.; Arns, T.; Grzyb, K.; Mock, A.; Herold-Mende, C.; Steino, A.; Brown, D.; May, P.; Miletic, H.; Malta, T. M.; Noushmehr, H.; Kwon, Y.-J.; Jahn, W.; Klink, B.; Tanner, G.; Stead, L. F.; Mittelbronn, M.; Skupin, A.; Hertel, F.; Bjerkvig, R.; Niclou, S. P.
10.1101/2020.04.24.057802 — cancer biology — Posted on 2020-04-25
835 Scaffold pore geometry influences bone-like tissue formation in dynamic cell culture conditions
Rubert, M.; Vetsch, J. R.; Lehtoviita, I.; Sommer, M.; Studart, A. R.; Mueller, R.; Hofmann, S.
10.1101/2020.04.24.060525 — bioengineering — Posted on 2020-04-25
837 Multi-modal characterization and simulation of human epileptic circuitry
Buchin, A.; de Frates, R.; Nandi, A.; Mann, R.; Chong, P.; Ng, L.; Miller, J.; Hodge, R. D.; Kalmbach, B.; Bose, S.; Rutishauser, U.; McConoughey, S.; Lein, E.; Berg, J.; Sorensen, S.; Gwinn, R.; Koch, C.; Ting, J. T.; Anastassiou, C. A.
10.1101/2020.04.24.060178 — neuroscience — Posted on 2020-04-25
839 In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales
Chen, J.; Madireddi, S.; Nagarkar, D.; Migdal, M.; Vander Heiden, J.; Chang, D.; Mukhyala, K.; Selvaraj, S.; Kadel, E. E.; Brauer, M. J.; Mariathasan, S.; Hunkapiller, J.; Jhunjhunwala, S.; Albert, M.; Hammer, C.
10.1101/2020.04.24.060459 — bioinformatics — Posted on 2020-04-25
842 A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
Li, T.; Chiou, B.; Gilman, C. K.; Luo, R.; Koshi, T.; Yu, D.; Oak, H. C.; Giera, S.; Johnson-Venkatesh, E.; Muthukumar, A. K.; Stevens, B.; Umemori, H.; Piao, X.
10.1101/2020.04.24.059840 — neuroscience — Posted on 2020-04-25
843 Repeat DNA-PAINT suppresses background and non-specific signals in optical nanoscopy
Clowsley, A. H.; Kaufhold, W. T.; Lutz, T.; Meletiou, A.; Di Michele, L.; Soeller, C.
10.1101/2020.04.24.059410 — molecular biology — Posted on 2020-04-25
844 Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes
Wolz, C.; Horvatek, P.; Hanna, A. M. F.; Gratani, F. l.; Keinhörster, D.; Korn, N.; Borisova, M.; Mayer, C.; Rejman, D.; M&aumder, U.
10.1101/2020.04.25.059725 — microbiology — Posted on 2020-04-25
845 Identification of stromal genes differentially expressed in lobular breast cancer highlights role for pregnancy-associated-plasma protein-A
Gomez-Cuadrado, L.; Zhao, H.; Souleimanova, M.; Noer, P. R.; Turnbull, A. K.; Oxvig, C.; Bertos, N.; Dixon, J. M.; Park, M.; Sims, A. H.; Brunton, V. G.
10.1101/2020.04.24.059386 — cancer biology — Posted on 2020-04-25
849 Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia
Lillywhite, A.; Woodhams, S. G.; Watson, D. J. G.; Li, L.; Burston, J. J.; Gowler, P. R. W.; Canals, M.; Walsh, D. A.; Hathway, G. J.; Chapman, V.
10.1101/2020.04.24.057570 — neuroscience — Posted on 2020-04-25
851 Chromosome-scale de novo diploid assembly of the apple cultivar 'Gala Galaxy'
Broggini, G. A. L.; Schlathölter, I.; Russo, G.; Copetti, D.; Yates, S. A.; Studer, B.; Patocchi, A.
10.1101/2020.04.25.058891 — genomics — Posted on 2020-04-25
854 Closed loop enhancement and neural decoding of human cognitive control
basu, i.; yousefi, a.; Crocker, B.; Zelmann, R.; Paulk, A. C.; Peled, N.; Ellard, K. K.; Weisholtz, D. S.; Cosgrove, G. R.; Deckersbach, T.; Eden, U.; Eskandar, E. N.; Dougherty, D. D.; Cash, S. S. S.; Widge, A. S.
10.1101/2020.04.24.059964 — bioengineering — Posted on 2020-04-25
857 Mapping the neural circuitry of predator fear in the nonhuman primate
Montardy, Q.; Kwan, W. C.; Mundinano, I. C.; Fox, D. M.; Wang, L.; Gross, C. T.; Bourne, J. A.
10.1101/2020.04.24.057869 — neuroscience — Posted on 2020-04-25
859 Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
Scott-Hewitt, N. J.; Perrucci, F.; Morini, R.; Erreni, M.; Mahoney, M.; Witkowska, A.; Carey, A.; Faggiani, E.; Schutz, L. T.; Mason, S.; Tamborini, M.; Passoni, L.; Filipello, F.; Jahn, R.; Stevens, B.; Matteoli, M.
10.1101/2020.04.24.059584 — neuroscience — Posted on 2020-04-25
860 The genomes of invasive coral Tubastraea spp. (Dendrophylliidae) as tool for the development of biotechnological solutions
Soares Souza, G. B.; Amaral, D.; Batista, D.; Torres, A. Q.; Serra, A. C. S.; Uliano-Silva, M.; Leomil, L.; Reis, A. C.; Matos, E. M.; Calderon, E.; Yu, V.; Dondero, F.; Sousa, S. M.; Baker, D.; Romão-Dumaresq, A. S.; REBELO, M. D. F.
10.1101/2020.04.24.060574 — evolutionary biology — Posted on 2020-04-25
861 Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance
Kovacs, A.; Vermeer, D. W.; Madeo, M.; Vermeer, S. J.; Williamson, C. S.; Rickel, A.; Stamp, J.; Lucido, C. T.; Cain, J.; Bell, M.; Morgan, M.; Yoon, J.-Y.; Mitchell, M. A.; Tulina, N.; Stuckelberger, S.; Budina, A.; Orman, D.; Jung, E.; Schwartz, L. E.; Eichwald, T.; Hong, Z.; Weimer, J.; Hooper, J. E.; Godwin, A. K.; Talbot, S.; Drapkin, R.; Vermeer, P. D.
10.1101/2020.04.24.058594 — cancer biology — Posted on 2020-04-25
864 Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism
Yang, Y.; Chen, S.; Peng, L.; Liu, X.; Kaushal, R.; Yuan, F.; Singh, S. K.; He, D.; Lv, S.; Vilchez, J. I.; Morcillo, R. J. L.; Wang, W.; Huang, W.; Lei, M.; Song, C.-P.; Zhu, J.-K.; Pare, P. W.; Zhang, H.
10.1101/2020.04.24.058990 — plant biology — Posted on 2020-04-25
866 The role of the meningeal lymphatic system in local inflammation and trigeminal nociception implicated in migraine pain
Mikhailov, N.; Koroleva, K.; Abdollahzadeh, A.; Giniatullina, R.; Gafurov, O.; Malm, T.; Sierra Lopez, A.; Tohka, J.; Noe, F. M.; Giniatullin, R.
10.1101/2020.04.25.060939 — neuroscience — Posted on 2020-04-25
867 Altered Expression of Cadherin-8 and Cadherin-11 in Neural Circuit Development: Implications for Autism
Frei, J. A.; Niescier, R. F.; Bridi, M. S.; Durens, M.; Nestor, J. E.; Yuan, X.; Dykxhoorn, D. M.; Nestor, M. W.; Huang, S.; Blatt, G. J.; Lin, Y.-C.
10.1101/2020.04.24.058438 — neuroscience — Posted on 2020-04-25
869 Integrative Omics for Informed Drug Repurposing: Targeting CNS Disorders
Shukla, R.; Henkel, N.; Alganem, K.; Hamoud, A.-r.; Reigle, J.; Alnafisah, R. S.; Eby, H. M.; Imami, A. S.; Creeden, J.; Miruzzi, S. A.; Meller, J.; Mccullumsmith, R. E.
10.1101/2020.04.24.060392 — neuroscience — Posted on 2020-04-25
872 Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women with Alzheimer's Disease
Paranjpe, M. D.; Belonwu, S.; Wang, J. K.; Oskotsky, T.; Gupta, A.; Taubes, A.; Zalocusky, K.; Paranjpe, I.; Glicksberg, B. S.; Huang, Y.; Sirota, M.
10.1101/2020.04.24.060558 — neuroscience — Posted on 2020-04-25
875 Novel class of OTU deubiquitinases regulate substrate ubiquitinationupon Legionella infection
Shin, D.; Bhattacharya, A.; Cheng, Y.-L.; Alonso, M. C.; Medipour, A. R.; Noort, G. J. v. d. H. v.; Ovaa, H.; Hummer, G.; Dikic, I.
10.1101/2020.04.25.060954 — molecular biology — Posted on 2020-04-25
881 Spectral niches reveal taxonomic identity and complementarity in plant communities
Schweiger, A. K.; Cavender-Bares, J.; Townsend, P. A.; Hobbie, S. E.; Madritch, M. D.; Kothari, S.; Grossman, J. J.; Gholizadeh, H.; Wang, R.; Gamon, J. A.
10.1101/2020.04.24.060483 — ecology — Posted on 2020-04-25
887 Geographic and subsequent biotic isolations led to a diversity anomaly of Heterotropa (Aristolochiaceae) in insular versus continental regions of the Sino-Japanese Floristic Region
Takahashi, D.; Feng, Y.; Sakaguchi, S.; Isagi, Y.; Qiu, Y.-X.; Li, P.; Lu, R.-S.; Lu, C.-T.; Chung, S.-W.; Lin, Y.-S.; Chen, Y.-C.; Nagano, A. J.; Kawaguchi, L.; Setoguchi, H.
10.1101/2020.04.25.060632 — plant biology — Posted on 2020-04-25
889 Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain
Aggarwal, S.; DeBerry, J. J.; Ahmad, I.; Prichard, L.; DeWitte, C. R.; Malik, S.; Merlin, J. S.; Goodin, B. R.; Heath, S. L.; Matalon, S.
10.1101/2020.04.24.059790 — pathology — Posted on 2020-04-25
894 Chromosome-level and haplotype-resolved genome assembly enabled by high-throughput single-cell sequencing of gamete genomes
Campoy, J. A.; Sun, H.; Goel, M.; Jiao, W.-B. A.; Folz-Donahue, K.; Kukat, C.; Rubio, M.; Ruiz, D.; Huettel, B.; Schneeberger, K.
10.1101/2020.04.24.060046 — genomics — Posted on 2020-04-25
895 Labile carbon limits late winter microbial activity near Arctic treeline
Sullivan, P. F.; Stokes, M. C.; McMillan, C. K.; Weintraub, M. N.
10.1101/2020.04.24.058198 — ecology — Posted on 2020-04-25
896 Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers
Okazaki, K.; Anzawa, H.; Liu, Z.; Ota, N.; Kitamura, H.; Onodera, Y.; Alam, M. M.; Matsumaru, D.; Suzuki, T.; Katsuoka, F.; Tadaka, S.; Motoike, I.; Watanabe, M.; Sakurada, A.; Okada, Y.; Yamamoto, M.; Suzuki, T.; kinoshita, k.; Sekine, H.; Motohashi, H.
10.1101/2020.04.24.060798 — cancer biology — Posted on 2020-04-25
897 Leveraging a WGS compression and indexing format with dynamic graph references to call structural variants.
English, A. C.; McCarthy, N.; Flickenger, R.; Maheshwari, S.; Meed, L.; Mangubat, A.; Shekar, S. N.
10.1101/2020.04.24.060202 — bioinformatics — Posted on 2020-04-25
900 GlobalFungi: Global database of fungal records from high-throughput-sequencing metabarcoding studies
Vetrovsky, T.; Morais, D.; Kohout, P.; Lepinay, C.; Algora Gallardo, C.; Awokunle Holla, S.; Bahnmann, B. D.; Bilohneda, K.; Brabcova, V.; D'Alo, F.; Human, Z. R.; Jomura, M.; Kolarik, M.; Kvasnickova, J.; Llado, S.; Lopez-Mondejar, R.; Martinovic, T.; Masinova, T.; Meszarosova, L.; Michalcikova, L.; Michalova, T.; Mundra, S.; Navratilova, D.; Odriozola, I.; Piche-Choquette, S.; Stursova, M.; Svec, K.; Tlaskal, V.; Urbanova, M.; Vlk, L.; Voriskova, J.; Zifcakova, L.; Baldrian, P.
10.1101/2020.04.24.060384 — ecology — Posted on 2020-04-25
903 Rescoring ensembles of protein-protein docking poses using consensus approaches
Launay, G.; Ohue, M.; Prieto Santero, J.; Matsuzaki, Y.; Hilpert, C.; Uchikoga, N.; Hayashi, T.; Martin, J.
10.1101/2020.04.24.059469 — bioinformatics — Posted on 2020-04-25
906 HiTaC: Hierarchical Taxonomic Classification of Fungal ITS Sequences
Miranda, F. M.; Azevedo, V. A. C.; Renard, B. Y.; Piro, V. C.; Ramos, R. T. J.
10.1101/2020.04.24.014852 — bioinformatics — Posted on 2020-04-25
907 Control of ribosomal protein synthesis by Microprocessor complex
Jiang, X.; Prabhakar, A.; Van der Voorn, S. M.; Ghatpande, P.; Celona, B.; Venkataramanan, S.; Calviello, L.; Lin, C.; Wang, W.; Black, B. L.; Floor, S. N.; Lagna, G.; Hata, A.
10.1101/2020.04.24.060236 — molecular biology — Posted on 2020-04-25
910 Comparison of the Hi-C, GAM and SPRITE methods by use of polymer models of chromatin
Fiorillo, L.; Musella, F.; Kempfer, R.; Chiariello, A. M.; Bianco, S.; Kukalev, A.; Irastorza-Azcarate, I.; Esposito, A.; Conte, M.; Prisco, A.; Pombo, A.; Nicodemi, M.
10.1101/2020.04.24.059915 — biophysics — Posted on 2020-04-25
911 Modified Bacterial Lipids Which Alter Membrane Surface Charge Reduce Binding of Antimicrobial Peptides
Simcock, P.; Bublitz, M.; Cipcigan, F.; Ryadnov, M.; Crain, J.; Stansfeld, P.; Sansom, M.
10.1101/2020.04.24.057349 — biophysics — Posted on 2020-04-25
912 ITPK1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis thaliana
Laha, N. P.; Dhir, Y. W.; Giehl, R. F. H.; Schaefer, E. M.; Gaugler, P.; Shishavan, Z. H.; Gulabani, H.; Mao, H.; Zheng, N.; von Wiren, N.; Jessen, H. J.; Saiardi, A.; Bhattacharjee, S.; Laha, D.; Schaaf, G.
10.1101/2020.04.23.058487 — plant biology — Posted on 2020-04-25
914 3D SYNAPTIC ORGANIZATION OF THE RAT CA1 AND ALTERATIONS INDUCED BY COCAINE SELF-ADMINISTRATION
Blazquez-Llorca, L.; Miguens, M.; Montero-Crespo, M.; Selvas, A.; Gonzalez-Soriano, J.; Ambrosio, E.; DeFelipe, J.
10.1101/2020.04.23.050575 — neuroscience — Posted on 2020-04-25
915 G protein-regulated endocytic trafficking of adenylyl cyclase type 9
Lazar, A. M.; Irannejad, R.; Baldwin, T. A.; Sundaram, A. B.; Gutkind, J. S.; Inoue, A.; Dessauer, C. W.; Von Zastrow, M.
10.1101/2020.04.23.057026 — cell biology — Posted on 2020-04-25
918 Big trees drive forest structure patterns across a lowland Amazon regrowth gradient
Maylla Fontoura Caron, T.; Rodriguez Chuma, V. J. U.; Arevalo Sandi, A. R.; Norris, D.
10.1101/2020.04.23.058289 — ecology — Posted on 2020-04-25
923 Mosquitoes (Diptera:Culicidae) in an indigenous settlement of the Magdalena State, Colombia
Parra Henao, G.; Perdomo Balaguera, E.; Carrasquilla Baza, D.; Perez Quintero, C. P.; Torres, E.; Molina, J.
10.1101/2020.04.23.056101 — ecology — Posted on 2020-04-25
926 Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses
dugourd, A.; Kuppe, C.; Sciacovelli, M.; Gjerga, E.; Emdal, K. B.; Bekker-Jensen, D. B.; Kranz, J.; Bindels, E. J. M.; Costa, S.; Olsen, J. V.; Frezza, C.; Kramann, R.; Saez-Rodriguez, J.
10.1101/2020.04.23.057893 — bioinformatics — Posted on 2020-04-25
928 DeepArk: modeling cis-regulatory codes of model species with deep learning
Cofer, E. M.; Raimundo, J.; Tadych, A.; Yamazaki, Y.; Wong, A. K.; Theesfeld, C. L.; Levine, M. S.; Troyanskaya, O. G.
10.1101/2020.04.23.058040 — bioinformatics — Posted on 2020-04-25
933 Physiological diversity enhanced by recurrent divergence and secondary gene flow within a grass species
Bianconi, M.; Dunning, L. T.; Curran, E. V.; Hidalgo, O.; Powell, R.; Mian, S.; Leitch, I.; Lundgren, M.; Manzi, S.; Vorontsova, M.; Besnard, G.; Osborne, C. P.; Olofsson, J. K.; Christin, P.-A.
10.1101/2020.04.23.053280 — evolutionary biology — Posted on 2020-04-25
934 Stroma secreted IL6 selects for stem-like population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways
Kesh, K.; Garrido, V. T.; Doesch, A.; Durden, B.; Gupta, V. K.; Sharma, N. S.; Lyle, M.; Nagathihalli, N.; Merchant, N.; Saluja, A.; Banerjee, S.
10.1101/2020.04.23.041509 — cancer biology — Posted on 2020-04-25
935 Succinct dynamic variation graphs
Eizenga, J. M.; Novak, A. M.; Kobayashi, E.; Villani, F.; Cisar, C.; Heumos, S.; Hickey, G.; Colonna, V.; Paten, B.; Garrison, E.
10.1101/2020.04.23.056317 — bioinformatics — Posted on 2020-04-25
938 Low-Bias Amplification for Robust DNA Data Readout
Gao, Y.; Chen, X.; Hao, J.; Zhang, C.; Qiao, H.; Ke, Y.; Qi, H.
10.1101/2020.02.09.940411 — synthetic biology — Posted on 2020-04-25
941 Repurposing a digital kitchen scale for neuroscience research: a complete hardware and software cookbook for PASTA
Virag, D.; Homolak, J.; Kodvanj, I.; Babic Perhoc, A.; Knezovic, A.; Osmanovic Barilar, J.; Salkovic-Petrisic, M.
10.1101/2020.04.10.035766 — neuroscience — Posted on 2020-04-25
944 Tracking crystallophore nucleating properties: setting-up a database for statistical analysis.
Girard, E.; Jiang, T.; Roux, A.; Engilberge, S.; Alsalman, Z.; Di Pietro, S.; Fanzetti, B.; Riobe, F.; Maury, O.
10.1101/2020.04.23.057596 — biochemistry — Posted on 2020-04-25
945 DriverGroup: A novel method for identifying drivergene groups
Pham, V. V. H.; Liu, L.; Bracken, C.; Goodall, G.; Li, J.; Le, T.
10.1101/2020.04.23.058719 — systems biology — Posted on 2020-04-25
948 Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections
Copp, J.; Pletzer, D.; Brown, A.; van der Heijden, J.; Miton, C. M.; Edgar, R. J.; Rich, M.; Little, R.; Williams, E.; Hancock, R. E. W.; Tokuriki, N.; Ackerley, D. F.
10.1101/2020.04.23.058875 — microbiology — Posted on 2020-04-25
949 A polyetic modelling framework for plant disease emergence
Willocquet, L.; Savary, S.; McDonald, B. A.; Mikaberidze, A.
10.1101/2020.04.23.057372 — ecology — Posted on 2020-04-25
950 Regulation of intracellular energy supplies by cell cycle kinetics using a single cell approach.
Galichon, P.; Lannoy, M.; Li, L.; Vandermeersch, S.; Valerius, M. T.; Hadchouel, J.; Bonventre, J. V.
10.1101/2020.04.24.054643 — cell biology — Posted on 2020-04-25
955 Cumulative distribution functions: An alternative approach to examine the triggering of prepared motor actions in the StartReact effect
McInnes, A. N.; Castellote, J. M.; Kofler, M.; Honeycutt, C. F.; Lipp, O. V.; Riek, S.; Tresilian, J. R.; Marinovic, W.
10.1101/2020.04.23.056929 — neuroscience — Posted on 2020-04-25
957 Myelinating Schwann cells use Warburg effect to sustain axonal physiology and function
DECK, M.; Van Hameren, G.; Campbell, G.; Bernard-Marissal, N.; Devaux, J.; Berthelot, J.; Lattard, A.; Medard, J.-J.; Gautier, B.; Quintana, P.; Chao De La Barca, J. M.; Reynier, P.; Lenaers, G.; Chrast, R.; Tricaud, N.
10.1101/2020.04.23.049056 — neuroscience — Posted on 2020-04-25
960 Shifting Baselines: Repeat bleaching drives coral physiotypes through environmental legacy and cellular memory
Wall, C. B.; Ricci, C.; Wen, A.; Ledbetter, B.; Klinger, D.; Mydlarz, L.; Gates, R. D.; Putnam, H.
10.1101/2020.04.23.056457 — ecology — Posted on 2020-04-25
961 Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma
kumar, s.; Buon, L.; Talluri, S.; Roncador, M.; Liao, C.; Zhao, J.; Shi, J.; Chakraborty, C.; Gonzalez, G. B.; Tai, Y.-T.; Prabhala, R.; Samur, M. K.; Munshi, N. C.; Shammas, M. A.
10.1101/2020.04.23.058230 — cancer biology — Posted on 2020-04-25
962 FaDA: A Shiny web application to accelerate common lab data analyses
Feseha, Y.; Moiteaux, Q.; Geffard, E.; Ramstein, G.; Brouard, S.; Danger, R.
10.1101/2020.04.23.055673 — bioinformatics — Posted on 2020-04-25
965 A mathematical investigation of chemotherapy-induced peripheral neuropathy
Verma, P.; Eaton, M.; Kienle, A.; Flockerzi, D.; Yang, Y.; Ramkrishna, D.
10.1101/2020.04.23.057851 — neuroscience — Posted on 2020-04-25
968 Identification of Differentially Expressed Gene Modules in Heterogeneous Diseases
Zolotareva, O.; Khakabimamaghani, S.; Isaeva, O. I.; Chervontseva, Z.; Savchik, A.; Ester, M.
10.1101/2020.04.23.055004 — bioinformatics — Posted on 2020-04-25
973 Cognitive regulation of multimodal food perception in the human brain
Janet, R.; Fournel, A.; Fouillen, M.; Derrington, E.; Bensafi, M.; dreher, j.-c.
10.1101/2020.04.23.057364 — neuroscience — Posted on 2020-04-25
976 Italian Odonates in the Pandora's Box: A Comprehensive DNA Barcoding Inventory Shows Taxonomic Warnings at the Holarctic Scale
Galimberti, A.; Assandri, G.; Maggioni, D.; Ramazzotti, F.; Baroni, D.; Bazzi, G.; Chiandetti, I.; Corso, A.; Ferri, V.; Galuppi, M.; Ilahiane, L.; La Porta, G.; Lorenzo, L.; Landi, F.; Mastropasqua, F.; Ramellini, S.; Santinelli, R.; Soldato, G.; Surdo, S.; Casiraghi, M.
10.1101/2020.04.23.056911 — zoology — Posted on 2020-04-25
980 Apparent Reconsolidation Interference Without Generalized Amnesia
Alfei, J. M.; De Gruy, H.; De Bundel, D.; Luyten, L.; Beckers, T.
10.1101/2020.04.23.056952 — neuroscience — Posted on 2020-04-25
987 The coronavirus proofreading exoribonuclease mediates extensive viral recombination
Gribble, J.; Pruijssers, A. J.; Agostini, M. L.; Anderson-Daniels, J.; Chappell, J. D.; Lu, X.; Stevens, L. J.; Routh, A. L.; Denison, M. R.
10.1101/2020.04.23.057786 — microbiology — Posted on 2020-04-25
989 LSTrAP-Crowd: Prediction of novel components of bacterial ribosomes with crowd-sourced analysis of RNA sequencing data
Hew, B.; Tan, Q. W.; Goh, W.; Ng, J. W. X.; Koh, K.; Rugdee, R. C. F.; Teng, Z. K.; Tan, J. X.; Yei, X.; Tan, Q. R.; Binte Sulaiman, I. S.; Gilia, S. M. L.; Villanueva, E. M. F.; Nguyen, S. T.; Putri, D. A.; Siying, J. T.; Johanan, T. Y. R.; Tan, J. W.; Gladys, K. S. N.; Ong, W. W.; Moo, J. R.; Koh, J.; Lim, P. X.; Teoh, S. W.; Tamilselvam, P.; Hui, H.; Chua, Y. X.; Ow Yeong, Y. K.; Jian Hua, T.; Chong, M. J.; Sho, Y. W.; Tang, B. J. X.; Kwantalalu, C. Y.; Binte Mohammad Rizal, N. A.; Tan, W. H.; Shan Chun, L.; Tan, S. Y. T.; Jia Ying, T.; Luminary, A. M.; Jia Jia, Jolyn, L.; Lunardi, V.; Low,
10.1101/2020.04.20.005249 — bioinformatics — Posted on 2020-04-25
991 Drosophila Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid
Wainwright, M.; Mendes, C. C.; Sekar, A.; Kroeger, B.; Hellberg, J. E. E. U.; Fan, S.-J.; Pavey, A.; Marie, P.; Leiblich, A.; Gandy, C.; Corrigan, L.; Patel, R. S.; Wigby, S.; Morris, J. F.; Goberdhan, D.; Wilson, C.
10.1101/2020.04.24.059238 — cell biology — Posted on 2020-04-25
992 Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation
Debets, M. F.; Tastan, O. Y.; Wisnovsky, S. P.; Malaker, S. A.; Angelis, N.; Moeckl, L. K. R.; Choi, J.; Flynn, H.; Wagner, L. J. S.; Bineva-Todd, G.; Antononopoulos, A.; Cioce, A.; Browne, W. M.; Li, Z.; Briggs, D. C.; Douglas, H. L.; Hess, G. T.; Agbay, A. J.; Roustan, C.; Kjaer, S.; Haslam, S. M.; Snijders, A. P.; Bassik, M. C.; Moerner, W. E.; Li, V. S. W.; Bertozzi, C. R.; Schumann, B.
10.1101/2020.04.23.057208 — synthetic biology — Posted on 2020-04-25
995 Klf4 methylated by Prmt1 is required for lineage segregation of epiblast and primitive endoderm
Zuo, Z.-y.; Yang, G.-h.; Wang, H.-y.; Zhang, Y.-j.; Cai, Y.; Chen, F.; Xiao, Y.; Cheng, M.-b.; Huang, Y.; Zhang, Y.
10.1101/2020.04.24.059055 — molecular biology — Posted on 2020-04-25
997 Auranofin resistance in Toxoplasma gondii decreases the accumulation of reactive oxygen species but does not target parasite thioredoxin reductase
Ma, C. I.; Tirtorahardjo, J. A.; Jan, S.; Schweizer, S. S.; Rosario, S. A. C.; Du, Y.; Zhang, J. J.; Morrissette, N. S.; Andrade, R. M.
10.1101/2020.04.23.058842 — microbiology — Posted on 2020-04-25
999 TAPBPR Promotes Antigen Loading on MHC-I Molecules Using a Peptide Trap
McShan, A. C.; Devlin, C. A.; Morozov, G. I.; Overall, S.; Moschidi, D.; Akella, N.; Procko, E.; Sgourakis, N. G.
10.1101/2020.04.24.059634 — immunology — Posted on 2020-04-25
1001 Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.
Coppin, E.; Sundarasetty, B. S.; Rahmig, S.; Blume, J.; Verheyden, N. A.; Bahlmann, F.; Ravens, S.; Schubert, U.; Schmid, J.; Ludwig, S.; von Kaisenberg, C.; Platz, A.; Naumann, R.; Ludwig, B.; Prinz, I.; Waskow, C.; Krueger, A.
10.1101/2020.04.24.060319 — immunology — Posted on 2020-04-25
1005 TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
Qiao, W.; Wong, K. H. M.; Shen, J.; Wang, W.; Wu, J.; Li, J.; Lin, Z.; Chen, Z.; Matinlinna, J. P.; Zheng, Y.; Wu, S.; Liu, X.; Lai, K. P.; Chen, Z.; Lam, Y. W.; Cheung, K. M. C.; Yeung, K. W. K.
10.1101/2020.04.24.059881 — cell biology — Posted on 2020-04-25
1006 Cell autonomous requirement of Neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis
Wei, X.; Franke, J.; Ost, M.; Wardelmann, K.; Boerno, S.; Timmermann, B.; Meierhofer, D.; Kleinridders, A.; Klaus, S.; Stricker, S.
10.1101/2020.04.24.059931 — developmental biology — Posted on 2020-04-25
1008 Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
Kalkreuter, E.; Bingham, K. S.; Keeler, A. M.; Lowell, A.; Schmidt, J. J.; Sherman, D. H.; Williams, G. J.
10.1101/2020.04.23.058214 — synthetic biology — Posted on 2020-04-25
1009 Repeated gain and loss of a single gene modulates the evolution of vascular pathogen lifestyles
Gluck-Thaler, E.; Cerutti, A.; Perez Quintero, A.; Butchacas, J.; Roman-Reyna, V.; Narayanan Madhaven, V.; Shantharaj, D.; Merfa, M. V.; Pesce, C.; Jauneau, A.; Lang, J. M.; Allen, C.; Verdier, V.; Gagnevin, L.; Szurek, B.; Cunnac, S.; Beckham, G. T.; De La Fuente, L.; Vancheva, T.; Kumar Patel, H.; Sonti, R. V.; Bragard, C.; Leach, J. E.; Noel, L. D.; Slot, J.; Koebnik, R.; Jacobs, J. M.
10.1101/2020.04.24.058529 — microbiology — Posted on 2020-04-25
1010 Human CD8+ T cells exhibit a shared antigen threshold for different effector responses
Abu-Shah, E.; Trendel, N.; Kruger, P.; Nguyen, J.; Pettmann, J.; Kutuzov, M.; Dushek, O.
10.1101/2020.04.24.059766 — immunology — Posted on 2020-04-25
1012 Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals
Adhya, D.; Swarup, V.; Nagy, R.; Dutan Polit, L.; Shum, C.; Valencia-Alarcon, E. P.; Jozwik, K.; Mendez, M. A.; Horder, J.; Loth, E.; Nowosiad, P.; Lee, I.; Skuse, D.; Flinter, F. A.; Murphy, D.; McAlonan, G.; Geschwind, D. H.; Price, J.; Carroll, J.; Srivastava, D. P.; Baron-Cohen, S.
10.1101/349415 — neuroscience — Posted on 2020-04-25
1016 CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways
Li, B.; Zheng, L.-S.; Zhang, C.-M.; Huang, Q.-J.; Guo, Y.-H.; Wang, L.-Q.; Yu, P.; Liu, S.-R.; Lin, Q.; Luo, Y.-X.; Zhou, H.; Yang, J.-H.; Qu, L.-H.
10.1101/2020.04.24.059162 — cell biology — Posted on 2020-04-25
1020 Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare
Le, N.-H.; Peters, K.; Espaillat, A.; Sheldon, J. R.; Gray, J.; Di Venanzio, G.; Lopez, J.; Djahanschiri, B.; Mueller, E. A.; Hennon, S. W.; Levin, P. A.; Ebersberger, I.; Skaar, E. P.; Cava, F.; Vollmer, W.; Feldman, M. F.
10.1101/2020.04.23.058008 — microbiology — Posted on 2020-04-25
1023 Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression
Nathan, A.; Beynor, J. I.; Baglaenko, Y.; Suliman, S.; Ishigaki, K.; Asgari, S.; Huang, C.-C.; Luo, Y.; Zhang, Z.; Lopez Tamara, K.; Jimenez, J.; Calderon, R. I.; Lecca, L.; van Rhijn, I.; Moody, B.; Murray, M. B.; Raychaudhuri, S.
10.1101/2020.04.23.057828 — immunology — Posted on 2020-04-25
1026 Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP-43-C pathology
Borghesani, V.; Battistella, G.; Mandelli, M. L.; Welch, A.; Weis, E.; Younes, K.; Neuhaus, J.; Grinberg, L. T.; Seeley, W. W.; Spina, S.; Miller, B. L.; Miller, Z.; Gorno-Tempini, M. L.
10.1101/847582 — neuroscience — Posted on 2020-04-24
1027 An optogenetic switch for the Set2 methyltransferase provides evidence for rapid transcription-dependent and independent dynamics of H3K36 methylation
Lerner, A. M.; Hepperla, A. J.; Keele, G. R.; Meriesh, H.; Yumerefendi, H.; Restrepo, D.; Zimmerman, S.; Bear, J.; Kuhlman, B.; Davis, I. J.; Strahl, B. D.
10.1101/2020.03.28.013706 — molecular biology — Posted on 2020-04-25
1030 A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors.
Fadason, T.; Gokuladhas, S.; Golovina, E.; Ho, D.; Farrow, S.; Nyaga, D. M.; Pan, H.; Karnani, N.; Wong, C.; Cooper, A.; Schierding, W.; O'Sullivan, J. M.
10.1101/2020.04.14.042002 — genomics — Posted on 2020-04-25
1035 Alterations of specific inhibitory circuits of the prefrontal cortex underlie abnormal network activity in a mouse model of Down syndrome
Zorrilla de San Martin, J.; Donato, C.; Peixoto, J.; Aguirre, A.; Choudhary, V.; De Stasi, A. M.; Lourenco, J.; Potier, M.-C.; Bacci, A.
10.1101/2020.02.24.963041 — neuroscience — Posted on 2020-04-24
1037 Validation of a SARS-CoV-2 spike ELISA for use in contact investigations and serosurveillance
Freeman, B.; Lester, S.; Mills, L.; Rasheed, M. A. U.; Moye, S.; Abiona, O.; Hutchinson, G.; Morales-Betoulle, M.; Krapinunaya, I.; Gibbons, A.; Chiang, C.-F.; Cannon, D.; Klena, J.; Johnson, J. A.; Owen, S. M.; Graham, B. S.; Corbett, K. S.; Thornburg, N. J.
10.1101/2020.04.24.057323 — immunology — Posted on 2020-04-24
1041 Multiple freeze-thaw cycles lead to a loss of consistency in poly(A)-enriched RNA sequencing
Kellman, B. P.; Baghdassarian, H. M.; Pramparo, T.; Shamie, I.; Gazestani, V. H.; Begzati, A.; Li, S.; Nalabolu, S.; Murray, S.; Lopez, L.; Pierce, K.; Courchesne, E.; Lewis, N. E.
10.1101/2020.04.01.020792 — bioinformatics — Posted on 2020-04-24
1045 Fussing about fission: defining variety among mainstream and exotic apicomplexan cell division modes
Gubbels, M.-J.; Keroack, C. D.; Dangoudoubiyam, S.; Worliczek, H. L.; Paul, A. S.; Bauwens, C.; Elsworth, B.; Engelberg, K.; Howe, D. K.; Coppens, I.; Duraisingh, M. T.
10.1101/2020.04.23.056333 — microbiology — Posted on 2020-04-24
1050 Evolution and molecular characteristics of SARS-CoV-2 genome
Bai, Y.; Jiang, D.; Lon, J. R.; Chen, X.; Hu, M.; Lin, S.; Chen, Z.; Meng, Y.; Du, H.
10.1101/2020.04.24.058933 — bioinformatics — Posted on 2020-04-24
1055 Boosting generalized recovery by combined optogenetic stimulation and training after stroke
Conti, E.; ALLEGRA mascaro, A. L.; Scaglione, A.; de Vito, G.; Calugi, F.; Pasquini, M.; Pizzorusso, T.; Micera, S.; Pavone, F. S.
10.1101/2020.03.05.974972 — neuroscience — Posted on 2020-04-24
1056 Repetitive Transcranial Magnetic Stimulation Activates Glial Cells and Inhibits Neurogenesis after Pneumococcal Meningitis
Lukas, M.; Oberhänsli, S.; Buri, M.; Le, N. D.; Grandgirard, D.; Bruggmann, R.; Müri, R. M.; Leib, S. L.
10.1101/2020.04.24.059337 — neuroscience — Posted on 2020-04-24
1059 REVEALING COVID-19 TRANSMISSION BY SARS-CoV-2 GENOME SEQUENCING AND AGENT BASED MODELLING
Rockett, R. J.; Arnott, A.; Lam, C.; Sadsad, R.; Timms, V.; Gray, K.-A.; Eden, J.-S.; Chang, S. L.; Gall, M.; Draper, J.; Sim, E.; Bachmann, N. L.; Carter, I.; Basile, K.; Byun, R.; O Sullivan, M. V.; Chen, S. C.-A.; Maddocks, S.; Sorrell, T. C.; Dwyer, D. E.; Holmes, E. C.; Kok, J.; Prokopenko, M.; Sintchenko, V.
10.1101/2020.04.19.048751 — microbiology — Posted on 2020-04-24
1061 Genomic, geographic and temporal distributions of SARS-CoV-2 mutations
Yang, H.-C.; Chen, C.-h.; Wang, J.-H.; Liao, H.-C.; Yang, C.-T.; Chen, C.-W.; Lin, Y.-C.; Kao, C.-H.; Liao, J. C.
10.1101/2020.04.22.055863 — microbiology — Posted on 2020-04-24
1066 Recellularization of bronchial extracellular matrix with primary bronchial smooth muscle cells
Ben Hamouda, S.; Vargas, A.; Boivin, R.; Miglino, M. A.; da Palma, R. K.; Lavoie, J.-P.
10.1101/2019.12.23.878645 — cell biology — Posted on 2020-04-24
1067 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching
Aspden, J. L.; Fontana, J.; O'Connell, M. J.; McCarthy, C. G.; Norris, K.; Agapiou, M.; Hopes, T. S.
10.1101/2020.01.20.913020 — biochemistry — Posted on 2020-04-24
1073 High diversity and variability of pipolins among a wide range of pathogenic Escherichia coli strains
Flament-Simon, S.-C.; De Toro, M.; Chuprikova, L.; Blanco, M.; Moreno-Gonzalez, J.; Salas, M.; Blanco, J.; Redrejo Rodriguez, M.
10.1101/2020.04.24.059261 — microbiology — Posted on 2020-04-24
1074 Alternative HIV-1 Non-Nucleoside Reverse Transcriptase Inhibition: Drugging the p51 subunit
Chan, K. F.; Su, C. T. T.; Krah, A.; Phua, S. X.; Bond, P. J.; Gan, S. K.
10.1101/699470 — microbiology — Posted on 2020-04-24
1075 Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells
Stanifer, M. L.; Kee, C.; Cortese, M.; triana, S.; Mukenhirn, M.; Kraeusslich, H.-G.; Alexandrov, T.; Bartenschlager, R.; Boulant, S.
10.1101/2020.04.24.059667 — microbiology — Posted on 2020-04-24
1076 Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes
Ding, S.; Pandey, A.; Feng, X.; Yang, J.; da Costa, L. F.; Mouneimne, R. B.; Rice-Ficht, A.; Bell, S. L.; Watson, R. O.; Patrick, K. L.; Qin, Q.-M.; Ficht, T. A.; de Figueiredo, P.
10.1101/2020.04.20.047621 — microbiology — Posted on 2020-04-24
1077 Introductions and early spread of SARS-CoV-2 in France
Gambaro, F.; Baidaliuk, A.; Behillil, S.; Donati, F.; Albert, M.; Alexandru, A.; Vanpeene, M.; Bizard, M.; Brisebarre, A.; Barbet, M.; Derrar, F.; van der Werf, S.; Enouf, V.; Simon-Loriere, E.
10.1101/2020.04.24.059576 — genomics — Posted on 2020-04-24
1078 Bacteria contribute to plant secondary compound degradation in a generalist herbivore system
Francoeur, C. B.; Khadempour, L.; Moreira-Soto, R. D.; Gotting, K.; Book, A. J.; Pinto-Tomas, A. A.; Keefover-Ring, K.; Currie, C. R.
10.1101/865212 — ecology — Posted on 2020-04-24
1079 Increased prostaglandin-D2 in male but not female STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation
Stelling, E.; Ricke-Hoch, M.; Erschow, S.; Hoffman, S.; Bergmann, A. K.; Heimerl, M.; Pietzsch, S.; Battmer, K.; Haase, A.; Stapel, B.; Scherr, M.; Binah, O.; Balligand, J.-L.; Hilfiker-Kleiner, D.
10.1101/2020.04.24.059287 — cell biology — Posted on 2020-04-24
1080 KnetMiner: a comprehensive approach for supporting evidence-based gene discovery and complex trait analysis across species
Hassani-Pak, K.; Singh, A.; Brandizi, M.; Hearnshaw, J.; Amberkar, S.; Phillips, A. L.; Doonan, J. H.; Rawlings, C.
10.1101/2020.04.02.017004 — bioinformatics — Posted on 2020-04-24
1081 Treating Influenza and SARS-CoV-2 via mRNA-encoded Cas13a
Blanchard, E. L.; Vanover, D.; Bawage, S. S.; Tiwari, P. M.; Rotolo, L.; Beyersdorf, J.; Peck, H. E.; Bruno, N. C.; Hincapie, R.; Finn, M. G.; Michel, F.; Lafontaine, E. R.; Hogan, R. J.; Zurla, C.; Santangelo, P. J.
10.1101/2020.04.24.060418 — bioengineering — Posted on 2020-04-24
1082 Search for SARS-CoV-2 inhibitors in currently approved drugs to tackle COVID-19 pandemia
Rodon, J.; Noguera-Julian, M.; Erkizia, I.; Valencia, A.; Guallar, V.; Carrillo, J.; Blanco, J.; Segales, J.; Clotet, B.; Vergara-Alert, J.; Izquierdo-Useros, N.
10.1101/2020.04.23.055756 — microbiology — Posted on 2020-04-24
1083 Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through upregulation of memory T-cells
Crane, A.; Chrostek, M. R.; Krishna, V. D.; Shiao, M.; Toman, N. G.; Pearce, C. M.; Tran, S. K.; Sipe, C. J.; Guo, W.; Voth, J. P.; Vaid, S.; Xie, H.; Lu, W.-C.; Swanson, W.; Grande, A. W.; Schleiss, M. R.; Bierle, C. J.; Cheeran, M. C.-J.; Low, W. C.
10.1101/2020.04.24.059253 — cancer biology — Posted on 2020-04-24
1088 Comparison of commercial RT-PCR diagnostic kits for COVID-19
van Kasteren, P. B.; van der Veer, B.; Brink, S. v. d.; Wijsman, L.; de Jonge, J.; van den Brandt, A.-M.; Molenkamp, R.; Reusken, C. B. E. M.; Meijer, A.
10.1101/2020.04.22.056747 — microbiology — Posted on 2020-04-24
1091 XGMix: Local-Ancestry Inference With Stacked XGBoost
Kumar, A.; Montserrat, D. M.; Bustamante, C.; Ioannidis, A.
10.1101/2020.04.21.053876 — genomics — Posted on 2020-04-24
1094 SARS-CoV-2 Isolation and Propagation from Turkish COVID-19 patients
Tastan, C.; Yurtsever, B.; Sir, G.; Dilek Kancagi, D.; Demir, S.; Abanuz, S.; Seyis, U.; Yildirim, M.; Kuzay, R.; Elibol, O.; Arbak, S.; Acikel Elmas, M.; Birdogan, S.; Sahin, E.; Ozcan, O.; Sezerman, U.; Ovali, E.
10.1101/2020.04.23.056309 — microbiology — Posted on 2020-04-24
1097 Circuits for integrating learnt and innate valences in the fly brain
Eschbach, C.; Fushiki, A.; Winding, M.; Afonso, B.; Andrade, I. V.; Cocanougher, B. T.; Eichler, K.; Gepner, R.; Si, G.; Valdes-Aleman, J.; Fetter, R. D.; Gershow, M.; Jefferis, G. S. X. E.; Samuel, A.; Truman, J. W.; Cardona, A.; Zlatic, M.
10.1101/2020.04.23.058339 — neuroscience — Posted on 2020-04-24
1098 The safety profile of Bald's eyesalve for the treatment of bacterial infections
Anonye, B. O.; Nweke, V.; Furner-Pardoe, J.; Gabrilska, R.; Rafiq, A.; Ukachukwu, F.; Bruce, J.; Lee, C.; Unnikrishnan, M.; Rumbaugh, K. P.; Snyder, L. A.; Harrison, F.
10.1101/2020.04.23.041749 — microbiology — Posted on 2020-04-24
1100 ER-PM contacts regulate apical domain formation in hepatocytes
Chung, G. H.; Burden, J. J.; Lorvellec, M.; Gissen, P.; Stefan, C. J.
10.1101/2020.04.23.057521 — cell biology — Posted on 2020-04-24
1101 SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell
Zhang, B.; Luo, X.; Bai, Y.; He, S.; Jiang, X.; Yang, Z.; Sun, S.; Lu, D.; Wei, P.; Liang, Y.; Peng, C.; Wang, Y.; Sheng, R.; Han, S.; Li, X.
10.1101/2020.04.24.059048 — cell biology — Posted on 2020-04-24
1102 Combining multivariate genomic approaches to elucidate the comorbidity between ASD and ADHD
Peyre, H.; Schoeler, T.; Liu, C.; Williams, C. M.; Hoertel, N.; Havdah, A.; Pingault, J.-B.
10.1101/2020.04.22.054825 — genetics — Posted on 2020-04-24
1104 The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly
Genoyer, E.; Kulej, K.; Hung, C.-t.; Thibault, P. A.; Azarm, K.; Takimoto, T.; Garcia, B. A.; Lee, B.; Lakdawala, S.; Weitzman, M. D.; Lopez, C. B.
10.1101/2020.04.23.058883 — microbiology — Posted on 2020-04-24
1105 Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome
Van Paemel, R.; De Koker, A.; Caggiano, C.; Morlion, A.; Mestdagh, P.; De Wilde, B.; Vandesompele, J.; De Preter, K.
10.1101/2020.04.23.055293 — genomics — Posted on 2020-04-24
1106 Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer
Kar, S.; Considine, D.; Tyrer, J.; Plummer, J.; Chen, S.; Dezem, F.; Barbeira, A.; Rajagopal, P.; Rosenow, W.; Anton, F.; Bodelon, C.; Chang-Claude, J.; Chenevix-Trench, G.; deFazio, A.; Doerk, T.; Ekici, A.; Ewing, A.; Fountzilas, G.; Goode, E.; Hartman, M.; Heitz, F.; Hillemanns, P.; Hogdall, E.; Hogdall, C.; Huzarski, T.; Jensen, A.; Karlan, B.; Khusnutdinova, E.; Kiemeney, L.; Kjaer, S.; Klapdor, R.; Kobel, M.; Li, J.; Liebrich, C.; May, T.; Olsson, H.; Permuth, J.; Peterlongo, P.; Radice, P.; Ramus, S.; Riggan, M.; Saloustros, E.; Simard, J.; Szafron, L.; Thompson, C.; Vierkant, R.; Winha
10.1101/2020.04.23.043653 — genetics — Posted on 2020-04-24
1109 The genetic variation of lactase persistence alleles in northeast Africa
Hollfelder, N.; Babiker, H.; Granehäll, L.; Schlebusch, C. M.; Jakobsson, M.
10.1101/2020.04.23.057356 — genetics — Posted on 2020-04-24
1112 Experimental and computational study on motor control and recovery after stroke: towards a constructive loop betweenexperimental and virtual embodiedneuroscience
Allegra Mascaro, A. L.; Falotico, E.; Petkoski, S.; Pasquini, M.; Vannucci, L.; Tort-Colet, N.; Conti, E.; Resta, F.; Spalletti, C.; Ramalingasetty, S. T.; von Arnim, A.; Formento, E.; Angelidis, E.; Blixhavn, C. H.; Leergaard, T. B.; Caleo, M.; Destexhe, A.; Ijspeert, A.; Micera, S.; Laschi, C.; Jirsa, V.; Gewaltig, M. O.; Pavone, F.
10.1101/2020.04.22.019661 — neuroscience — Posted on 2020-04-24
1113 Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform
Avet, C.; Mancini, A.; Breton, B.; Le Gouill, C.; Hauser, A. S.; Normand, C.; Kobayashi, H.; Gross, F.; Hogue, M.; Lukasheva, V.; Morissette, S.; Fauman, E.; Fortin, J.-P.; Schann, S.; Leroy, X.; Gloriam, D. E.; Bouvier, M.
10.1101/2020.04.20.052027 — pharmacology and toxicology — Posted on 2020-04-24
1114 Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer
Mao, C.; Shen, C.; Li, C.; Shen, D.-D.; Xu, C.-J.; Zhang, S.; Zhou, R.; Shen, Q.; Chen, L.-N.; Jiang, Z.; Liu, J.; Zhang, Y.
10.1101/2020.04.21.053488 — molecular biology — Posted on 2020-04-24
1115 Molecular Basis for the Adaptive Evolution of Environment Sensing by H-NS Proteins
Zhao, X.; Kharchenko, V.; Shahul Hameed, U. F.; Liao, C.; Huser, F.; Remington, J. M.; Radhakrishnan, A.; Jaremko, M.; Jaremko, Łukasz; Arold, S. T.; Li, J.
10.1101/2020.04.21.053520 — biochemistry — Posted on 2020-04-24
1117 Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin
Saudou, F.; Bruyere, J.; Abada, Y.-S.; Vitet, H. M.; Fontaine, G.; Deloulme, J.-C.; Cës, A.; Denarier, E.; Pernet-Gallay, K.; Andrieux, A.; Humbert, S.; Potier, M.-C.; Delatour, B.
10.1101/2020.04.21.052506 — neuroscience — Posted on 2020-04-24
1118 Effect of storage conditions on peripheral leukocytes transcriptome
Xing, Y.; Yang, X.; Chen, X.; Zhu, S.; Xu, J.; Chen, Y.; Zeng, J.; Chen, F.; Johnson, M.; Jiang, H.; Wang, W.-J.
10.1101/2020.04.21.054296 — molecular biology — Posted on 2020-04-24
1119 CeMbio - The C. elegans microbiome resource
Dirksen, P.; Assie, A.; Zimmermann, J.; Zhang, F.; Tietje, A.-M.; Marsh, S. A.; Felix, M.-A.; Shapira, M.; Kaleta, C.; Schulenburg, H.; Samuel, B. S.
10.1101/2020.04.22.055426 — microbiology — Posted on 2020-04-24
1120 Local adaptation of Legionella pneumophila within a hospital hot water system increases tolerance to copper
Bedard, E.; Trigui, H.; Liang, J.; Doberva, M.; Paranjape, K.; Lalancette, C.; Faucher, S. P.; Prevost, M.
10.1101/2020.04.22.054569 — microbiology — Posted on 2020-04-24
1122 Cellular expression and functional roles of all 26 neurotransmitter GPCRs in the C. elegans egg-laying circuit
Fernandez, R. W.; Wei, K.; Wang, E. Y.; Mikalauskaite, D.; Olson, A.; Pepper, J.; Christie, N.; Kim, S.; Koelle, M. R.
10.1101/2020.04.23.037242 — neuroscience — Posted on 2020-04-24
1124 The SSU1 checkup, a rapid tool for detecting chromosomal rearrangements of the Saccharomyces cerevisiae chromosome XVI. An ecological and technological study on wine yeast.
MARULLO, P.; Claisse, O.; Raymond Eder, M. L.; Feghali, N.; Bernard, M.; Legras, J.-L.; Albertin, W.; Rosa, A. L.; Masneuf-Pomarede, I.
10.1101/2020.04.23.055350 — microbiology — Posted on 2020-04-24
1125 C. elegans episodic swimming is driven by multifractal kinetics
Ikeda, Y.; Jurica, P.; Kimura, H.; Takagi, H.; Zbigniew, S.; Kiyono, K.; Arata, Y.; Sako, Y.
10.1101/2020.04.22.056606 — animal behavior and cognition — Posted on 2020-04-24
1129 Sex dependent gene activity in the human body
Hartman, R. J. G.; Mokry, M.; Pasterkamp, G.; den Ruijter, H. M.
10.1101/2020.04.22.055053 — systems biology — Posted on 2020-04-24
1130 Diurnal metabolic regulation of isoflavones and soyasaponins in soybean roots
Matsuda, H.; Nakayasu, M.; Aoki, Y.; Yamazaki, S.; Nagano, A. J.; Yazaki, K.; Sugiyama, A.
10.1101/2020.04.22.056598 — plant biology — Posted on 2020-04-24
1132 Copy Number Variation at 16p11.2 Imparts Transcriptional Alterations in Neural Development in an hiPSC-derived Model of Corticogenesis
Roth, J. G.; Muench, K. L.; Asokan, A.; Mallett, V. M.; Gai, H.; Verma, Y.; Weber, S.; Charlton, C.; Fowler, J. L.; Loh, K. M.; Dolmetsch, R. E.; Palmer, T. D.
10.1101/2020.04.22.055731 — neuroscience — Posted on 2020-04-24
1133 Genetic dissection of glutamatergic neuron subpopulations and developmental trajectories in the cerebral cortex
Matho, K. S. H.; Huilgol, D.; Galbavy, W.; Kim, G.; He, M.; An, X.; Lu, J.; Wu, P.; Di Bella, D. J.; Shetty, A. S.; Palaniswamy, R.; Hatfield, J.; Raudales, R.; Narasimhan, A.; Gamache, E.; Levine, J. M.; Tucciarone, J.; Mitra, P. P.; Osten, P.; Arlotta, P.; Huang, Z. J.
10.1101/2020.04.22.054064 — neuroscience — Posted on 2020-04-24
1134 Common brain networks between major depressive disorder and symptoms of depression that are validated for independent cohorts
Yamashita, A.; Sakai, Y.; Yamada, T.; Yahata, N.; Kunimatsu, A.; Okada, N.; Itahashi, T.; Hashimoto, R.-i.; Mizuta, H.; Ichikawa, N.; Takamura, M.; Okada, G.; Yamagata, H.; Harada, K.; Matsuo, K.; Tanaka, S.; Kawato, M.; Kasai, K.; Kato, N.; Takahashi, H.; Okamoto, Y.; Yamashita, O.; Imamizu, H.
10.1101/2020.04.22.056432 — neuroscience — Posted on 2020-04-24
1137 Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity
Zhou, X.; Zhu, X.; Li, C.; Li, Y.; Ye, Z.; Shapiro, V. M.; Copland, J. A.; Hitosugi, T.; Bernlohr, D. A.; Sun, J.; Zeng, H.
10.1101/2020.04.22.028613 — immunology — Posted on 2020-04-24
1138 Adapting genotyping-by-sequencing and variant calling for heterogeneous stock rats
Gileta, A. F.; Gao, J.; Bimschleger, H. V.; St. Pierre, C. L.; Gopalakrishnan, S.; Palmer, A. A.
10.1101/523043 — genetics — Posted on 2020-04-24
1141 Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seq
Zhao, W.; Dovas, A.; Spinazzi, E. F.; Levitin, H. M.; Upadhyayula, P.; Sudhakar, T.; Marie, T.; Otten, M. L.; Sisti, M.; Bruce, J. N.; Canoll, P.; Sims, P. A.
10.1101/2020.04.22.056341 — cancer biology — Posted on 2020-04-24
1146 Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
Horne, C. R.; Venugoapl, H.; Panjikar, S.; Henrickson, A.; Brookes, E.; North, R. A.; Murphy, J. M.; Friemann, R.; Griffin, M. D. W.; Ramm, G.; Demeler, B.; Dobson, R. C. J.
10.1101/2020.04.22.056440 — molecular biology — Posted on 2020-04-24
1149 Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Duwaerts, C. C.; Siao, K.; Soon, R. K.; Her, C.; Iwawaki, T.; Kohno, K.; Mattis, A. N.; Maher, J. J.
10.1101/2020.04.23.058446 — cell biology — Posted on 2020-04-24
1150 Adaptation and Selection Shape Clonal Evolution During Residual Disease and Recurrence
Walens, A.; Lin, J.; Damrauer, J. S.; Lupo, R.; Newcomb, R.; Fox, D. B.; Mabe, N. W.; Gresham, J.; De Buysscher, T.; Kelkar, H.; Mieczkowski, P.; Owzar, K.; Alvarez, J. V.
10.1101/2020.04.22.055780 — cancer biology — Posted on 2020-04-24
1153 Charge-Driven Phase Separation of RNA and Proteins without Disorder
Dutagaci, B.; Nawrocki, G.; Goodluck, J.; Lapidus, L. J.; Feig, M.
10.1101/2020.04.23.057901 — biophysics — Posted on 2020-04-24
1160 A comprehensive benchmarking of WGS-based structural variant callers
Sarwal, V.; Niehus, S.; Ayyala, R.; Chang, S.; Lu, A.; Darci-Maher, N.; Littman, R.; Wesel, E.; Castellanos, J.; Chikka, R.; Distler, M. G.; Eskin, E.; Flint, J.; Mangul, S.
10.1101/2020.04.16.045120 — bioinformatics — Posted on 2020-04-24
1161 Development of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics: a Proof of Concept Investigation
Asthana, V.; Stern, B. S.; Tang, Y.; Bugga, P.; Li, A.; Ferguson, A.; Asthana, A.; Bao, G.; Drezek, R. A.
10.1101/2020.04.22.055905 — bioengineering — Posted on 2020-04-24
1162 Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study
Rua, C.; Clarke, W. T.; Driver, I. D.; Mougin, O.; Morgan, A. T.; Clare, S.; Francis, S.; Muir, K.; Porter, D.; Wise, R.; Carpenter, A.; Wiliams, G. B.; Rowe, J. T.; Bowtell, R.; Rodgers, C. T.
10.1101/2020.04.22.055624 — neuroscience — Posted on 2020-04-24
1163 Microglia-targeted dendrimer-2PMPA therapy robustly inhibits GCPII and improves cognition in a mouse model of multiple sclerosis
Hollinger, K. R.; Sharma, A.; Tallon, C.; Lovell, L.; Thomas, A. G.; Zhu, X.; Kambhampati, S. P.; Liaw, K.; Sharma, R.; Rojas, C.; Rais, R.; Kannan, S.; Kannan, R. M.; Slusher, B.
10.1101/2020.04.22.055228 — neuroscience — Posted on 2020-04-24
1164 Ontogeny and function of the circadian clock in intestinal organoids
Rosselot, A. E.; Park, M.; Matsu-Ura, T.; Wu, G.; Flores, D. E.; Subramanian, K. R.; Lee, S.; Sundaram, N.; Broda, T. R.; McCauley, H. A.; Hawkins, J. A.; Chetal, K.; Salomonis, N.; Shroyer, N. F.; Helmrath, M. A.; Wells, J. M.; Hogenesch, J.; Moore, S. R.; Hong, C. I.
10.1101/2020.04.22.053223 — molecular biology — Posted on 2020-04-24
1167 Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity
Parks, S.; Gao, T.; Jimenez Awuapura, N.; Ayathamattam, J.; Chabosseau, P. L.; Marchetti, P.; Johnson, P.; Bosco, D.; Kalvakolanu, D. V.; Valdivia, H. H.; Rutter, G. A.; Leclerc, I.
10.1101/2020.04.23.053322 — cell biology — Posted on 2020-04-24
1168 Tension causes structural unfolding of intracellular intermediate filaments
Fleissner, F.; Kumar, S.; Klein, N.; Wirth, D.; Dhiman, R.; Schneider, D.; Bonn, M.; Parekh, S. H.
10.1101/2020.04.22.054379 — biophysics — Posted on 2020-04-24
1169 Label-free single-instance protein detection in vitrified cells
Rickgauer, J. P.; Choi, H.; Lippincott-Schwartz, J.; Denk, W.
10.1101/2020.04.22.053868 — biophysics — Posted on 2020-04-24
1173 Development of mPing-based Activation Tags for Crop Insertional Mutagenesis
Johnson, A.; Mcassey, E.; Diaz, S.; Reagin, J.; Parrilla, D. R.; Nguyen, H.; Stec, A.; McDaniel, L. A. L.; Clemente, T. E.; Stupar, R. M.; Parrott, W. A.; Hancock, C. N.
10.1101/2020.04.22.055970 — plant biology — Posted on 2020-04-24
1174 Female-specific upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity
Millington, J. W.; Chao, C.; Sun, Z.; Basner-Collins, P. J.; Brownrigg, G. P.; Wat, L. W.; Hudry, B.; Miguel-Aliaga, I.; Rideout, E. J.
10.1101/2020.04.22.054239 — physiology — Posted on 2020-04-24
1175 P2X-GCaMPs as versatile tools for imaging extracellular ATP signaling
Ollivier, M.; Beudez, J.; Linck, N.; Grutter, T.; Compan, V.; Rassendren, F.
10.1101/2020.04.23.057513 — neuroscience — Posted on 2020-04-24
1176 Intrinsic, dynamic and effective connectivity among large-scale brain networks modulated by oxytocin
Jiang, X.; Ma, X.; Geng, Y.; Zhao, Z.; Zhou, F.; Zhao, W.; Yao, S.; Yang, S.; Zhao, Z.; Becker, B.; Kendrick, K. M.
10.1101/2020.04.22.055038 — neuroscience — Posted on 2020-04-24
1177 Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia
Cramer, T.; Gill, R.; Thirouin, Z. S.; Vaas, M.; Sampath, S.; Noya, S. B.; Chang, P. K. Y.; Wu, P.; Barker, P.; Paolicelli, R. C.; Klohs, J.; McKinney, A. R.; Tyagarajan, S. K.
10.1101/2020.04.22.055087 — neuroscience — Posted on 2020-04-24
1178 Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity
Chiu, C.; Morse, T.; Nani, F.; Knoflach, F.; Hernandez, M.-C.; Jadi, M.; Higley, M.
10.1101/2020.04.22.055137 — neuroscience — Posted on 2020-04-24
1181 Mask, the Drosophila Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamics
Zhu, M.; Martinez, D. A.; Guidry, J. J.; Majeste, N.; Mao, H.; Yanofsky, S.; Tian, X.; Wu, C.
10.1101/2020.04.22.056051 — neuroscience — Posted on 2020-04-24
1182 Engineering highly multivalent sperm-binding IgG antibodies for potent non-hormonal female contraception
Shrestha, B.; Schaefer, A.; Saada, J.; Yong, Z.; Jacobs, T. M.; Chavez, E. C.; Omsted, S. S.; Vincent, K.; Moench, T. R.; Lai, S. K.
10.1101/2020.04.22.055301 — molecular biology — Posted on 2020-04-24
1183 Comparative proteomics analysis identifies L-FABP as a putative biomarker of graft injury during liver transplantation
Chen, M.; Lin, X.; Zhang, Y.; Zhao, Q.; Mei, P.; Chen, Y.; Guo, Z.; Wu, L.; Ma, Y.; Wang, D.; Ju, W.; He, X.
10.1101/2020.04.22.055442 — molecular biology — Posted on 2020-04-24
1186 Fused in sarcoma regulates DNA replication timing and progression
Jia, W.; Scalf, M.; Tonzi, P.; Milliken, R. J.; Kim, S. H.; Guns, W.; Liu, L.; Mastrocola, A.; Smith, L. M.; Huang, T. T.; Tibbetts, R. S.
10.1101/2020.04.22.055343 — genomics — Posted on 2020-04-24
1187 The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae
Alme, E. B.; Stevenson, E.; Krogan, N. J.; Swaney, D. L.; Toczyski, D. P.
10.1101/2020.04.22.055699 — genetics — Posted on 2020-04-24
1188 Adaptive evolution of hybrid bacteria by horizontal gene transfer
Power, J. J.; Pinheiro, F.; Pompei, S.; Kovacova, V.; Yuksel, M.; Rathmann, I.; Forster, M.; Lassig, M.; Maier, B.
10.1101/2020.04.23.057174 — evolutionary biology — Posted on 2020-04-24
1198 Blood RNA Profiles are Diagnostic for Severity in Human Acute Spinal Cord Injury
Kyritsis, N.; Torres-Espin, A.; Schupp, P. G.; Huie, J. R.; Chou, A.; Duong Fernandez, X.; Thomas, L. H.; Tsolinas, R. E.; Hemmerle, D. D.; Pascual, L. U.; Singh, V.; Pan, J. Z.; Talbott, J. F.; Whetstone, W. D.; Burke, J. F.; DiGiorgio, A. M.; Weinstein, P. R.; Manley, G. T.; Dhall, S. S.; Ferguson, A. R.; Oldham, M. C.; Bresnahan, J. C.; Beattie, M. S.
10.1101/2020.04.15.037325 — neuroscience — Posted on 2020-04-24
1199 Fussing about fission: defining variety among mainstream and exotic apicomplexan cell division modes
Gubbels, M.-J.; Keroack, C. D.; Dangoudoubiyam, S.; Worliczek, H. L.; Paul, A. S.; Bauwens, C.; Elsworth, B.; Engelberg, K.; Howe, D. K.; Coppens, I.; Duraisingh, M. T.
10.1101/2020.04.23.056333 — microbiology — Posted on 2020-04-24
1203 NK cells orchestrate splenic cDC1 migration to potentiate antiviral protective CD8+ T cell responses
Ghilas, S.; Ambrosini, M.; Cancel, J.-C.; Masse, M.; Lelouard, H.; Dalod, M.; Crozat, K.
10.1101/2020.04.23.057463 — immunology — Posted on 2020-04-24
1207 Combining genotype, phenotype, and environmental data to delineate site-adjusted provenance strategies for ecological restoration
Carvalho, C. d. S.; Forester, B. R.; Mitre, S. K.; Alves, R.; Imperatriz-Fonseca, V. L.; Ramos, S. J.; Resende-Moreira, L. C.; Siqueira, J. O.; Trevelin, L. C.; Caldeira, C. F.; Gastauer, M.; Jaffe, R.
10.1101/2019.12.11.872747 — ecology — Posted on 2020-04-24
1208 Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes
Ware, K. E.; Gupta, S.; Eng, J.; Kemeny, G.; Puviindran, B. J.; Foo, W.-C.; Crawford, L. A.; Almquist, R. G.; Runyambo, D.; Thomas, B. C.; Sheth, M. U.; Agarwal, A.; Pierobon, M.; Petricoin, E. F.; Corcoran, D. L.; Freedman, J.; Patierno, S. R.; Zhang, T.; Gregory, S.; Sychev, Z.; Drake, J. M.; Armstrong, A. J.; Somarelli, J.
10.1101/2020.04.22.050385 — cancer biology — Posted on 2020-04-24
1210 Side-Impact Collision: Mechanics of Obstacle Negotiation in Sidewinding Snakes
Astley, H. C.; Rieser, J. M.; Kaba, A.; Paez, V. M.; Tomkinson, I.; Mendelson, J. R.; Goldman, D. I.
10.1101/2020.04.22.055681 — animal behavior and cognition — Posted on 2020-04-24
1212 Analysis of ongoing neuronal activity evoked by continuous speech with computational corpus linguistics methods
Schilling, A.; Tomasello, R.; Henningsen-Schomers, M. R.; Surendra, K.; Haller, M.; Karl, V.; Uhrig, P.; Maier, A.; Krauss, P.
10.1101/2020.04.21.052720 — neuroscience — Posted on 2020-04-24
1214 Cognitive Deficits and Altered Functional Brain Network Organization in Pediatric Brain Tumor Patients
Anandarajah, H.; Seitzman, B. A.; McMichael, A.; Dworetsky, A.; Coalson, R. S.; Jiang, C.; Gu, H.; Barbour, D. L.; Schlaggar, B. L.; Limbrick, D. D.; Rubin, J. B.; Shimony, J. S.; Perkins, S. M.
10.1101/2020.04.22.055459 — neuroscience — Posted on 2020-04-24
1216 Pancreatic beta cell selective deletion of mitofusins 1 and 2 (Mfn1 and Mfn2) disrupts mitochondrial architecture and abrogates glucose-stimulated insulin secretion in vivo
Georgiadou, E.; Muralidharan, C.; Martinez, M.; Chabosseau, P.; Tomas, A.; Wern, F. Y. S.; Stylianides, T.; Rothery, S. M.; Gregorio, A. D.; Leclerc, I.; Ali, Y.; Linnemann, A. K.; Rodriguez, T. A.; Rutter, G. A.
10.1101/2020.04.22.055384 — molecular biology — Posted on 2020-04-24
1218 STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters
Boudewijns, R.; Thibaut, H. J.; Kaptein, S. J. F.; Li, R.; Vergote, V.; Seldeslachts, L.; De Keyzer, C.; Sharma, S.; Jansen, S.; Van Weyenbergh, J.; Ma, J.; Martens, E.; Bervoets, L.; Van Buyten, T.; Jacobs, S.; Liu, Y.; Marti-Carreras, J.; Vanmechelen, B.; Wawina-Bokalanga, T.; Delang, L.; Rocha-Pereira, J.; Coelmont, L.; Chiu, W.; Leyssen, P.; Heylen, E.; Schols, D.; Wang, L.; Close, L.; Matthijnssens, J.; Van Ranst, M.; Schramm, G.; Van Laere, K.; Opdenakker, G.; Maes, P.; Weynand, B.; Cawthorne, C.; Vande Velde, G.; Wang, Z.; Neyts, J.; Dallmeier, K.
10.1101/2020.04.23.056838 — microbiology — Posted on 2020-04-24
1220 Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection
GHIGO, J.-M.; STRESSMANN, F. A.; BERNAL-BAYARD, J.; PEREZ-PASCUAL, D.; AUDRAIN, B.; RENDUELES, O.; BRIOLAT, V.; BRUCHMANN, S.; VOLANT, S.; GHOZLANE, A.; HAUSSLER, S.; DUCHAUD, E.; LEVRAUD, J.-P.
10.1101/2020.04.23.058222 — microbiology — Posted on 2020-04-24
1221 The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteins
McCarthy, K. R.; Timpona, J. L.; Jenni, S.; Brusic, V.; Johnson, W. E.; WHELAN, S. P. J.; Robinson-McCarthy, L. R.
10.1101/2020.04.22.056234 — microbiology — Posted on 2020-04-24
1222 Mosquito densoviruses: the revival of a biological control agent against urban Aedes vectors of arboviruses
PERRIN, A.; Gosselin-Grenet, A.-S.; Rossignol, M.; Ginibre, C.; Scheid, B.; Lagneau, C.; Chandre, F.; Baldet, T.; Ogliastro, M.; Bouyer, J.
10.1101/2020.04.23.055830 — microbiology — Posted on 2020-04-24
1223 Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo
Weston, S.; Coleman, C. M.; Sisk, J. M.; Haupt, R.; Logue, J.; Matthews, K.; Frieman, M.
10.1101/2020.03.25.008482 — microbiology — Posted on 2020-04-24
1224 FOXO1 promotes HIV Latency by suppressing ER stress in T cells
Vallejo-Gracia, A.; Chen, I. P.; Perrone, R.; Besnard, E.; Boehm, D.; Battivelli, E.; Tezil, T.; Krey, K.; Raymond, K. A.; Hull, P. A.; Walter, M.; Habrylo, I.; Cruz, A.; Deeks, S.; Pillai, S. K.; Verdin, E.; Ott, M.
10.1101/2020.04.23.058123 — immunology — Posted on 2020-04-23
1225 Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks
Amimeur, T.; Shaver, J. M.; Ketchem, R. R.; Taylor, J. A.; Clark, R. H.; Smith, J.; Van Citters, D.; Siska, C. C.; Smidt, P.; Sprague, M.; Kerwin, B. A.; Pettit, D.
10.1101/2020.04.12.024844 — immunology — Posted on 2020-04-23
1226 Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis
Tsuchiya, H.; Ota, M.; Sumitomo, S.; Ishigaki, K.; Suzuki, A.; Sakata, T.; Tsuchida, Y.; Inui, H.; Hirose, J.; Kochi, Y.; Kadono, Y.; Shirahige, K.; Tanaka, S.; Yamamoto, K.; Fujio, K.
10.1101/861781 — immunology — Posted on 2020-04-24
1231 Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19
Han, L.; Wei, X.; Liu, C.; Volpe, G.; Wang, Z.; Pan, T.; Yuan, Y.; Lei, Y.; Lai, Y.; Ward, C.; Yu, Y.; Wang, M.; Shi, Q.; Wu, T.; Wu, L.; Liu, Y.; Wang, C.; Zhang, Y.; Sun, H.; Yu, H.; Zhuang, Z.; Tang, T.; Huang, Y.; Lu, H.; Xu, L.; Xu, J.; Cheng, M.; Liu, Y.; Wong, C. W.; Tan, T.; Ji, W.; Maxwell, P. H.; Yang, H.; Wang, J.; Zhu, S.; Liu, S.; Xu, X.; Hou, Y.; Esteban, M. A.; Liu, L.
10.1101/2020.04.10.022103 — cell biology — Posted on 2020-04-24
1234 Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
Ortiz Bezara, M. E.; Thurman, A.; Pezzulo, A.; Leidinger, M. R.; Klesney-Tait, J. A.; Karp, P. H.; Tan, P.; Wohlford-Lenane, C.; McCray, P. B.; Meyerholz, D. K.
10.1101/2020.04.22.056127 — cell biology — Posted on 2020-04-23
1236 Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2
Heiser, K.; McLean, P. F.; Davis, C. T.; Fogelson, B.; Gordon, H. B.; Jacobson, P.; Hurst, B. L.; Miller, B. J.; Alfa, R. W.; Earnshaw, B. A.; Victors, M. L.; Chong, Y. T.; Haque, I. S.; Low, A. S.; Gibson, C. C.
10.1101/2020.04.21.054387 — systems biology — Posted on 2020-04-23
1237 A curated list of genes that control elemental accumulation in plants.
Whitt, L.; Ricachenevsky, F.; Ziegler, G.; Clemens, S.; Walker, E.; Maathuis, F. J. M.; Kear, P.; Baxter, I.
10.1101/456384 — plant biology — Posted on 2020-04-23
1238 Pulmonary acini exhibit complex changes during postnatal rat lung development
Haberthür, D.; Yao, E.; Barre, S. F.; Cremona, T. P.; Tschanz, S. A.; Schittny, J. C.
10.1101/786681 — physiology — Posted on 2020-04-23
1240 Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning
Song, Z.; Zou, S.; Zhou, W.; Huang, Y.; Shao, L.; Yuan, J.; Gou, X.; Jin, W.; Wang, Z.; Chen, X.; Ding, X.; Liu, J.; Yu, C.; Ku, C.; Liu, C.; Sun, Z.; Xu, G.; Wang, Y.; Zhang, X.; Wang, D.; Wang, S.; Xu, W.; Davis, R. C.; Shi, H.
10.1101/2020.01.30.927749 — pathology — Posted on 2020-04-23
1241 Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease
Naganuma, R.; Yabe, I.; Takeuchi, M.; Morishita, K.; Nakane, S.; Takase, R.; Takahashi-Iwata, I.; Matsushima, M.; Otsuki, M.; Shiraishi, H.; Sasaki, H.
10.1101/2020.04.23.057679 — neuroscience — Posted on 2020-04-23
1242 Altered visual population receptive fields in human albinism
Alvarez, I.; Smittenaar, R.; Handley, S. E.; Liasis, A.; Sereno, M. I.; Schwarzkopf, D. S.; Clark, C. A.
10.1101/726141 — neuroscience — Posted on 2020-04-23
1244 Preliminary support for a 'dry swab, extraction free' protocol for SARS-CoV-2 testing via RT-qPCR
Srivatsan, S.; Han, P. D.; van Raay, K.; Wolf, C. R.; McCulloch, D. J.; Kim, A. E.; Brandstetter, E.; Martin, B.; Gehring, J.; Chen, W.; Seattle Flu Study Investigators, ; Kosuri, S.; Konnick, E. Q.; Lockwood, C. M.; Reider, M. J.; Nickerson, D. A.; Chu, H. Y.; Shendure, J.; Starita, L. M.
10.1101/2020.04.22.056283 — molecular biology — Posted on 2020-04-23
1245 Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from COVID-19 virus
Peng, Q.; Peng, R.; Yuan, B.; Zhao, J.; Wang, M.; Wang, X.; Wang, Q.; Sun, Y.; Fan, Z.; Qi, J.; Gao, G. F.; Shi, Y.
10.1101/2020.04.23.057265 — microbiology — Posted on 2020-04-23
1246 Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals Broad Potential Host Range of SARS-CoV-2
Liu, Y.; Hu, G.; Wang, Y.; Zhao, X.; Ji, F.; Ren, W.; Gong, M.; Ju, X.; Li, C.; Hong, J.; Zhu, Y.; Cai, X.; Wu, J.; Lan, X.; Xie, Y.; Wang, X.; Yuan, Z.; Zhang, R.; Ding, Q.
10.1101/2020.04.22.046565 — microbiology — Posted on 2020-04-23
1248 In-host population dynamics of M. tuberculosis during treatment failure
Vargas, R.; Freschi, L.; Marin, M.; Epperson, E.; Smith, M.; Oussenko, I.; Durbin, D.; Strong, M.; Salfinger, M.; Farhat, M. R.
10.1101/726430 — genomics — Posted on 2020-04-23
1249 Genetic Architecture of Maize Rind Strength Revealed by the Analysis of Divergently Selected Populations
Kumar, R.; Gyawali, A.; Morrison, G. D.; Saski, C. A.; Robertson, D. J.; Tharayil, N.; Schafer, R. J.; Beissinger, T. M.; Sekhon, R. S.
10.1101/2020.04.14.041517 — genetics — Posted on 2020-04-23
1250 Population connectivity predicts vulnerability to white-nose syndrome in the Chilean myotis (Myotis chiloensis) - a genomics approach
Lilley, T.; Sävilammi, T. M.; Ossa, G.; Blomberg, A. S.; Vasemägi, A.; Yung, V.; Vendrami, D. L.; Johnson, J. S.
10.1101/2020.04.07.029256 — evolutionary biology — Posted on 2020-04-23
1252 Bidirectional Wnt signaling between endoderm and mesoderm confer tracheal identity in mouse and human.
Kishimoto, K.; Furukawa, K. T.; Luz-Madrigal, A.; Yamaoka, A.; Matsuoka, C.; Habu, M.; Alev, C.; Zorn, A.; Morimoto, M.
10.1101/758235 — developmental biology — Posted on 2020-04-23
1253 A mathematical model of ctDNA shedding predicts tumor detection size
Avanzini, S.; Kurtz, D. M.; Chabon, J. J.; Moding, E. J.; Hori, S. S.; Gambhir, S. S.; Alizadeh, A. A.; Diehn, M.; Reiter, J. G.
10.1101/2020.02.12.946228 — cancer biology — Posted on 2020-04-23
1254 Lymph Node Morphology in Stage II Colorectal Cancer
Greenwood, A.; Keating, J.; Kenwright, D.; Shekouh, A.; Dalzell, A.; Dennett, E.; Danielson, K.
10.1101/2020.04.21.054205 — cancer biology — Posted on 2020-04-23
1257 Programmable low-cost DNA-based platform for viral RNA detection
Zhou, L.; Chandrasekaran, A. R.; Punnoose, J. A.; Bonenfant, G.; Charles, S.; Levchenko, O.; Badu, P.; Cavaliere, C.; Pager, C. T.; Halvorsen, K.
10.1101/2020.01.12.902452 — bioengineering — Posted on 2020-04-23
1258 TARGETED PROTEOMICS FOR THE DETECTION OF SARS-COV-2 PROTEINS.
Bezstarosti, K.; Lamers, M. M.; Haagmans, B. L.; Demmers, J. A.
10.1101/2020.04.23.057810 — biochemistry — Posted on 2020-04-23
1260 Coronavirus surveillance of wildlife in the Lao People's Democratic Republic detects viral RNA in rodents
McIver, D. J.; Silithammavong, S.; Theppangna, W.; Gillis, A.; Douangngeun, B.; Khammavong, K.; Singhalath, S.; Duong, V.; Buchy, P.; Olson, S. H.; Keatts, L.; Fine, A. E.; Greatorex, Z.; Gilbert, M.; LeBreton, M.; Saylors, K.; Joly, D. O.; Rubin, E. M.; Lange, C. E.
10.1101/2020.04.22.056218 — microbiology — Posted on 2020-04-23
1262 TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders
Chatzinakos, C.; Lee, D.; Na, C.; Vladimirov, V.; Docherty, A.; Webb, B.; Riley, B.; Flint, J.; Kendler, K.; Daskalakis, N.; Bacanu, S.-A.
10.1101/373050 — bioinformatics — Posted on 2020-04-23
1263 High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms
Czech-Sioli, M.; Günther, T.; Therre, M.; Spohn, M.; Indenbirken, D.; Theiss, J.; Riethdorf, S.; Qi, M.; Alawi, M.; Wülbeck, C.; Fernandez-Cuesta, I.; Esmek, F.; Becker, J.; Grundhoff, A.; Fischer, N.
10.1101/2020.04.23.057703 — molecular biology — Posted on 2020-04-23
1272 Structural basis for decoding active histone methylation marks by Polycomb Repressive Complex 2
Finogenova, K.; Bonnet, J.; Poepsel, S.; Schäfer, I. B.; Finkl, K.; Schmid, K.; Litz, C.; Strauss, M.; Benda, C.; Müller, J.
10.1101/2020.04.22.054684 — biochemistry — Posted on 2020-04-23
1274 Lipid specificity of the immune effector perforin
Hodel, A. W.; Rudd-Schmidt, J.; Trapani, J. A.; Voskoboinik, I.; Hoogenboom, B.
10.1101/2020.04.22.054890 — biophysics — Posted on 2020-04-23
1275 RADSex: a computational workflow to study sex determination using Restriction Site-Associated DNA Sequencing data
Feron, R.; Pan, Q.; Wen, M.; Imarazene, B.; Jouanno, E.; Anderson, J.; Herpin, A.; Journot, L.; Parrinello, H.; Klopp, C.; Kottler, V. A.; Roco, A. S.; Du, K.; Kneitz, S.; Adolfi, M.; Wilson, C. A.; McCluskey, B.; Amores, A.; Desvignes, T.; Goetz, F. W.; Takanashi, A.; Kawaguchi, M.; Detrich, H. W.; Oliveira, M.; Nobrega, R.; Sakamoto, T.; Nakamoto, M.; Wargelius, A.; Karlsen, O.; Wang, Z.; Stöck, M.; Waterhouse, R. M.; Braasch, I.; Postlethwait, J. H.; Schartl, M.; Guiguen, Y.
10.1101/2020.04.22.054866 — bioinformatics — Posted on 2020-04-23
1276 DNA micro-disk for the management of DNA-based data storage with index and write-once-read-many (WORM) memory features
Choi, Y.; Bae, H. J.; Lee, A. C.; Choi, H.; Lee, D.; Ryu, T.; Hyun, J.; Kim, S.; Kim, H.; Song, S.-H.; Kim, K.; Park, W.; Kwon, S.
10.1101/2020.04.22.054502 — bioengineering — Posted on 2020-04-23
1279 Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates
Ren, W.; Sun, H.; Gao, G. F.; Chen, J.; Sun, S.; Zhao, R.; Gao, G.; Hu, Y.; Zhao, G.; Chen, Y.; Jin, X.; Fang, F.; Chen, J.; Wang, Q.; Gong, S.; Gao, W.; Sun, Y.; Su, J.; He, A.; Cheng, X.; Li, M.; Xia, C.; Li, M.; Sun, L.
10.1101/2020.04.21.052209 — immunology — Posted on 2020-04-23
1280 Egg-surface bacteria deter oviposition by the oriental fruit fly Bactrocera dorsalis
Li, H.; Ren, L.; Xie, M.; Gao, Y.; He, M.; Hassan, B.; Lu, Y.; Cheng, D.
10.1101/2020.04.22.054999 — ecology — Posted on 2020-04-23
1281 SynergyAge: a curated database for synergistic and antagonistic interactions of longevity-associated genes
Bunu, G.; Toren, D.; Ion, C. F.; Barardo, D.; Sarghie, L.; Grigore, L. G.; de Magalhaes, J. P.; Fraifeld, V.; Tacutu, R.
10.1101/2020.04.22.054767 — systems biology — Posted on 2020-04-23
1282 UMI-Gen: a UMI-based reads simulator for variant calling evaluation in paired-end sequencing NGS libraries
Sater, V.; Viailly, P.-J.; Lecroq, T.; Ruminy, P.; Berard, C.; Prieur-Gaston, E.; Jardin, F.
10.1101/2020.04.22.027532 — bioinformatics — Posted on 2020-04-23
1284 High frequency neuronal bursting is essential for circadian and sleep behaviors in Drosophila
Fernandez-Chiappe, F.; Frenkel, L.; Colque, C. C.; Ricciuti, A.; Hahm, B.; Cerredo, K.; Muraro, N. I.; Ceriani, M. F.
10.1101/2020.04.20.051441 — neuroscience — Posted on 2020-04-23
1285 A Substantia Innominata-midbrain Circuit Controls a General Aggressive State
Zhu, Z.; Ma, Q.; Yang, H.; Miao, L.; Pan, L.; Li, K.; Zhang, X.; Wu, J.; Hao, S.; Lin, S.; Ma, X.; Hao, Y.; Yu, Y.-q.; Duan, S.
10.1101/2020.04.22.047670 — neuroscience — Posted on 2020-04-23
1289 German-wide interlaboratory study compares consistency, accuracy and reproducibility of whole-genome short read sequencing
Uelze, L.; Borowiak, M.; Brinks, E.; Deneke, C.; Stingl, K.; Kleta, S.; Tausch, S. H.; Szabo, K.; Wöhlke, A.; Malorny, B.
10.1101/2020.04.22.054759 — genomics — Posted on 2020-04-23
1290 Actin in Dendritic Spines Self-Organizes into a Critical State
Bonilla-Quintana, M.; Woergoetter, F.; D'Este, E.; Tetzlaff, C.; Fauth, M.
10.1101/2020.04.22.054577 — biophysics — Posted on 2020-04-23
1293 Network and pathway expansion of genetic disease associations identifies successful drug targets
MacNamara, A.; Nakic, N.; Hurle, M.; Guo, K.; Sieber, K.; Amin, A.; Gutteridge, A.
10.1101/2020.04.22.051144 — genetics — Posted on 2020-04-23
1295 A subcellular atlas of Toxoplasma reveals the functional context of the proteome
Barylyuk, K.; Koreny, L.; Ke, H.; Butterworth, S.; Crook, O. M.; Lassadi, I.; Gupta, V.; Tromer, E. C.; Mourier, T.; Stevens, T. J.; Breckels, L. M.; Pain, A.; Lilley, K. S.; Waller, R. F.
10.1101/2020.04.23.057125 — cell biology — Posted on 2020-04-23
1297 Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis
Falkowski, K.; Bielecka, E.; Thogersen, I. B.; Bochenska, O.; Płaza, K.; Kalinska, M.; Sasiadek, L.; Magoch, M.; Pecak, A.; Wisniewska, M.; Gruba, N.; Wysocka, M.; Wojtysiak, A.; Brzezinska-Bodal, M.; Sychowska, K.; Pejkovska, A.; Rehders, M.; Butler, G.; Overall, C. M.; Brix, K.; Dubin, G.; Lesner, A.; Kozik, A.; Enghild, J. J.; Potempa, J.; Kantyka, T.
10.1101/2020.04.23.057109 — biochemistry — Posted on 2020-04-23
1299 A midbrain dynorphin circuit promotes threat generalization
Zweifel, L. S.; Fellinger, L.; Jo, Y. S.; Hunker, A. C.; Soden, M. E.
10.1101/2020.04.21.053892 — neuroscience — Posted on 2020-04-23
1302 Microglial Associated Circadian Rhythms of Perineuronal Net Composition
Pantazopoulos, H.; Gisabella, B.; Rexrode, L.; Benefield, D.; Yildiz, E.; Seltzer, P.; Valeri, J.; Chelini, G.; Reich, A.; Ardelt, M.; Berretta, S.
10.1101/2020.04.21.053751 — neuroscience — Posted on 2020-04-23
1303 Cytotoxic lymphocytes use mechanosurveillance to target biophysical vulnerabilities in cancer
Tello-Lafoz, M.; Srpan, K.; Hu, J.; Romin, Y.; Calo, A.; Hsu, K. C.; Massague, J.; Huse, M.; Er, E. E.
10.1101/2020.04.21.054304 — immunology — Posted on 2020-04-23
1304 Multiscale cardiac imaging to capture the whole heart and its internal cellular architecture, with applications to congenital heart disease
Rykiel, G.; Lopez, C. S.; Riesterer, J. L.; Fries, I.; Deosthali, S.; Courchaine, K.; Maloyan, A.; Thornburg, K.; Rugonyi, S.
10.1101/2020.04.22.055418 — developmental biology — Posted on 2020-04-23
1308 Electrical Oscillations of Brain Microtubules
Gutierrez, B. C.; Cantiello, H. F.; Cantero, M. d. R.
10.1101/2020.04.21.054155 — biophysics — Posted on 2020-04-23
1309 Inspecting abundantly expressed genes in male strobili in sugi (Cryptomeria japonica D. Don) via a highly accurate cDNA assembly
Fu-Jin, W.; Ueno, S.; Ujino-Ihara, T.; Saito, M.; Tsumura, Y.; Higuchi, Y.; Hirayama, S.; Iwai, J.; Hakamata, T.; Moriguchi, Y.
10.1101/2020.04.21.054320 — bioinformatics — Posted on 2020-04-23
1311 Aerial High-Throughput Phenotyping Enabling Indirect Selection for Grain Yield at the Early-generation Seed-limited Stages in Breeding Programs
Krause, M. R.; Mondal, S.; Crossa, J.; Singh, R.; Pinto, F.; Haghighattalab, A.; Shresthra, S.; Rutkoski, J.; Gore, M. A.; Sorrells, M. E.; Poland, J.
10.1101/2020.04.21.054163 — genetics — Posted on 2020-04-23
1316 Regulation of blood cell transdifferentiation by oxygen sensing neurons in Drosophila
Corcoran, S.; Mase, A.; Hashmi, Y.; Ouyang, D.; Augsburger, J.; Jacobs, T.; Kukar, K.; Brueckner, K.
10.1101/2020.04.22.056622 — developmental biology — Posted on 2020-04-23
1320 Lymph Node Morphology in Stage II Colorectal Cancer
Greenwood, A.; Keating, J.; Kenwright, D.; Shekouh, A.; Dennett, E.; Dalzell, A.; Danielson, K.
10.1101/2020.04.21.054205 — cancer biology — Posted on 2020-04-23
1321 Term Matrix: A novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns
Wood, V.; Carbon, S.; Harris, M. A.; Lock, A.; Engel, S. R.; Hill, D. P.; Van Auken, K.; Attrill, H.; Feuermann, M.; Gaudet, P.; Lovering, R. C.; Poux, S.; Rutherford, K. M.; Mungall, C. J.
10.1101/2020.04.21.045195 — bioinformatics — Posted on 2020-04-23
1322 PlanktonScope: Affordable modular imaging platform for citizen oceanography
Pollina, T.; Larson, A.; Lombard, F.; Li, H.; Colin, S.; Vargas, C. d.; Prakash, M.
10.1101/2020.04.23.056978 — bioengineering — Posted on 2020-04-23
1324 Redesigned Reporter Gene for Improved Proton Exchange-based Molecular MRI Contrast
Perlman, O.; Ito, H.; Gilad, A. A.; McMahon, M. T.; Chiocca, E. A.; Nakashima, H.; Farrar, C. T.
10.1101/2020.04.21.053157 — bioengineering — Posted on 2020-04-23
1326 Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence
Dahl, H.; Kanchwala, M.; Thomas-Jardin, S.; Sandhu, A.; Kanumuri, P.; Xing, C.; Delk, N.
10.1101/2020.04.21.054452 — cancer biology — Posted on 2020-04-23
1330 Population genetics of sugar kelp in the Northwest Atlantic region using genome-wide markers
Mao, X.; Augyte, S.; Huang, M.; Hare, M.; Bailey, D.; Umanzor, S.; Marty-Rivera, M.; Robbins, K.; Yarish, C.; Lindell, S.; Jannink, J.-L.
10.1101/2020.04.21.050930 — genetics — Posted on 2020-04-23
1335 TGF-beta/Activin ligand Myoglianin couples muscle growth to the initiation of metamorphosis
He, L. L.; Shin, S. H.; Wang, Z.; Yuan, I.; Weschler, R.; Chiou, A.; Koyama, T.; Nijhout, F.; Suzuki, Y.
10.1101/2020.04.21.053835 — developmental biology — Posted on 2020-04-23
1336 Ligand-directed covalent labelling of a GPCR with a fluorescent tag
Stoddart, L. A.; Kindon, N. D.; Otun, O.; Harwood, C. R.; Patera, F.; Veprintsev, D. B.; Woolard, J.; Briddon, S. J.; Franks, H. A.; Hill, S. J.; Kellam, B.
10.1101/2020.04.21.053405 — pharmacology and toxicology — Posted on 2020-04-23
1338 T2 heterogeneity provides a sensitive measure of early tumor response to radiotherapy
Tomaszewski, M. R.; Dominguez Viqueira, W.; Ortiz, A.; Shi, Y.; Costello, J. R.; Enderling, H.; Rosenberg, S. A.; Gillies, R. J.
10.1101/2020.04.21.053736 — biophysics — Posted on 2020-04-23
1339 Determining the Depth Limit of Bioluminescent Sources in Scattering Media
Raghuram, A.; Ye, F.; Adams, J. K.; Shaner, N.; Robinson, J.; Veeraraghavan, A.
10.1101/2020.04.21.044982 — bioengineering — Posted on 2020-04-23
1341 Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
Tabdanov, E. D.; Rodriguez-Merced, N. J.; Cartagena-Rivera, A.; Puram, V.; Callaway, M.; Ensminger, E.; Pomeroy, E.; Yamamoto, K.; Lahr, W. S.; Webber, B. R.; Moriarity, B.; Zhovmer, A.; Provenzano, P.
10.1101/2020.04.21.051615 — cancer biology — Posted on 2020-04-23
1342 Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
Ferguson, I. D.; Lin, Y.-H. T.; Lam, C.; Shao, H.; Hale, M.; Tharp, K. M.; Mariano, M. C.; Steri, V.; Wang, D.; Phojanokong, P.; Tuomivaara, S. T.; Hann, B.; Driessen, C.; Ness, B. V.; Gestwicki, J. E.; Wiita, A. P.
10.1101/2020.04.21.052456 — cancer biology — Posted on 2020-04-23
1343 TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes
Zang, R.; Castro, M. F. G.; McCune, B. T.; Zeng, Q.; Rothlauf, P. W.; Sonnek, N. M.; Liu, Z.; Brulois, K. F.; Wang, X.; Greenberg, H. B.; Diamond, M. S.; Ciorba, M. A.; Whelan, S. P. J.; Ding, S.
10.1101/2020.04.21.054015 — microbiology — Posted on 2020-04-23
1344 Gene co-expression is distance-dependent in breast cancer
Garcia-Cortes, D.; de Anda-Jauregui, G.; Fresno, C.; Hernandez-Lemus, E.; Espinal-Enriquez, J.
10.1101/399253 — systems biology — Posted on 2020-04-23
1351 Methylphenidate boosts choices of mental labor over leisure depending on baseline striatal dopamine
Hofmans, L.; Papadopetraki, D.; van den Bosch, R.; Määttä, J. I.; Froböse, M. I.; Zandbelt, B. B.; Westbrook, A.; Verkes, R.-J.; Cools, R.
10.1101/859637 — neuroscience — Posted on 2020-04-23
1353 Two dynamically distinct circuits driving inhibition in sensory thalamus
Martinez-Garcia, R. I.; Voelcker, B.; Zaltsman, J. B.; Patrick, S. L.; Stevens, T. R.; Connors, B. W.; Cruikshank, S. J.
10.1101/2020.04.16.044487 — neuroscience — Posted on 2020-04-23
1354 Restoring the pattern of perineuronal net sulphation corrects age-related memory loss
Yang, S.; Gigout, S.; Molinari, A.; Naito-Matsui, Y.; Hilton, S.; Foscarin, S.; Nieuwenhuis, B.; Verhaagen, J.; Pizzorusso, T.; Saksida, L.; Bussey, T.; Kitagawa, H.; Kwok, J.; Fawcett, J.
10.1101/2020.01.03.894188 — neuroscience — Posted on 2020-04-23
1355 Rapid 'multi-directed' cholinergic transmission at central synapses
Sethuramanujam, S.; Matsumoto, A.; McIntosh, J. M.; Jing, M.; Li, Y.; Berson, D.; Yonehara, K.; Awatramani, G. B.
10.1101/2020.04.18.048330 — neuroscience — Posted on 2020-04-23
1356 Pharmacological evidence for the implication of noradrenaline in effort
Borderies, N.; Mattioni, J. C. L.; Bornert, P.; Gilardeau, S.; Bouret, S.
10.1101/714923 — neuroscience — Posted on 2020-04-23
1357 Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women
Trakoshis, S.; Martinez-Canada, P.; Rocchi, F.; Canella, C.; You, W.; Chakrabarti, B.; Ruigrok, A. N.; Bullmore, E.; Suckling, J.; Markicevic, M.; Zerbi, V.; MRC AIMS Consortium, ; Baron-Cohen, S.; Gozzi, A.; Lai, M.-C.; Panzeri, S.; Lombardo, M. V.
10.1101/2020.01.16.909531 — neuroscience — Posted on 2020-04-23
1358 Lateral gene transfer of anion-conducting channelrhodopsins between green algae and giant viruses
Rozenberg, A.; Oppermann, J.; Wietek, J.; Fernandez Lahore, R. G.; Sandaa, R.-A.; Bratbak, G.; Hegemann, P.; Beja, O.
10.1101/2020.04.15.042127 — microbiology — Posted on 2020-04-23
1361 Genotypic characterization of the U.S. peanut core collection
Otyama, P. I.; Kulkarni, R.; Chamberlin, K.; Ozias-Akins, P. K.; Chu, J.; Lincoln, L. M.; MacDonald, G. E.; Anglin, N. L.; Dash, S.; Bertioli, D.; Fernandez-Baca, D. F.; Graham, M. A.; Cannon, S. B.; Cannon, E. K.
10.1101/2020.04.17.047019 — genomics — Posted on 2020-04-23
1364 Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC
Sorial, A. K.; Hofer, I. M.; Tselepi, M.; Cheung, K.; Parker, E.; Deehan, D. J.; Rice, S. J.; Loughlin, J.
10.1101/2020.01.28.917401 — genetics — Posted on 2020-04-23
1366 How do invasion syndromes evolve? An experimental evolution approach using the ladybird Harmonia axyridis
Foucaud, J.; Hufbauer, R. A.; Ravigne, V.; Olazcuaga, L.; Loiseau, A.; Ausset, A.; Wang, S.; Zang, L.-S.; Lemenager, N.; Tayeh, A.; Weyna, A.; Gneux, P.; Bonnet, E.; Dreuilhe, V.; Poutout, B.; Estoup, A.; Facon, B.
10.1101/849968 — evolutionary biology — Posted on 2020-04-23
1368 Counteracting Genome Instability by p53-dependent Mintosis
Liang, J.; Niu, Z.; Yu, X.; Zhang, B.; Wang, M.; Ruan, B.; Qin, H.; Zhang, X.; Zheng, Y.; Gu, S.; Sai, X.; Tai, Y.; Gao, L.; Ma, L.; Chen, Z.; Huang, H.; Wang, X.; Sun, Q.
10.1101/2020.01.16.908954 — cell biology — Posted on 2020-04-23
1373 A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma
Nawroth, J. C.; Lucchesi, C.; Cheng, D.; Shukla, A.; Nguyen, J.; Shroff, T.; Karalis, K.; Lee, H.-H.; Alves, S.; Hamilton, G.; Salmon, M.; Villenave, R.
10.1101/2020.02.02.931055 — bioengineering — Posted on 2020-04-23
1376 Ecosystem Entanglement and the Propagation of Nutrient-Driven Instability
McCann, K.; MacDougall, A.; Bieg, C.; Fryxell, J.; Fussmann, G.; Cazelles, K.; Cristescu, M.; Gellner, G.; LaPointe, B.; Gonzalez, A.
10.1101/2020.04.20.050302 — ecology — Posted on 2020-04-23
1380 LSTrAP-Crowd: Prediction of novel components of bacterial ribosomes with crowd-sourced analysis of RNA sequencing data
Koh, K.; Goh, W.; Tan, Q. W.; Rugdee, R. C. F.; Hew, B.; Ng, J. W. X.; Teng, Z. K.; Tan, J. X.; Yei, X.; Tan, Q. R.; Binte Sulaiman, I. S.; Gilia, S. M. L.; Villanueva, E. M. F.; Nguyen, S. T.; Putri, D. A.; Siying, J. T.; Johanan, T. Y. R.; Tan, J. W.; Gladys, K. S. N.; Ong, W. W.; Moo, J. R.; Koh, J.; Lim, P. X.; Teoh, S. W.; Tamilselvam, P.; Hui, H.; Chua, Y. X.; Ow Yeong, Y. K.; Jian Hua, T.; Chong, M. J.; Sho, Y. W.; Tang, B. J. X.; Kwantalalu, C. Y.; Binte Mohammad Rizal, N. A.; Tan, W. H.; Shan Chun, L.; Tan, S. Y. T.; Jia Ying, T.; Luminary, A. M.; Jia Jia, Jolyn, L.; Lunardi, V.; Low,
10.1101/2020.04.20.005249 — bioinformatics — Posted on 2020-04-23
1383 Exploring Chromosomal Structural Heterogeneity AcrossMultiple Cell Lines
Cheng, R. R.; Contessoto, V.; Aiden, E. L.; Wolynes, P. G.; Di Pierro, M.; Onuchic, J. N.
10.1101/2020.03.21.001917 — biophysics — Posted on 2020-04-23
1385 Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model
Kartalou, G.-I.; Pereira, A. R. S.; Endres, T.; Lesnikova, A.; Casarotto, P.; Pousinha, P.; Delanoe, K.; Edelmann, E.; Castren, E.; Gottmann, K.; Marie, H.; Lessmann, V.
10.1101/2019.12.15.868026 — neuroscience — Posted on 2020-04-23
1387 Phenotypic heterogeneity in particle size is a viral mechanism of persistence
Li, T.; Li, Z.; Deans, E. E.; Mittler, E.; Liu, M.; Chandran, K.; Ivanovic, T.
10.1101/843177 — microbiology — Posted on 2020-04-23
1388 Environmentally sensitive hotspots in the methylome of the early human embryo
Silver, M. J.; Saffari, A.; Kessler, N. J.; Chandak, G. R.; Fall, C. H.; Issarapu, P.; Dedaniya, A.; Betts, M.; Moore, S. E.; James, P. T.; Monk, D.; Prentice, A. M.
10.1101/777508 — genomics — Posted on 2020-04-23
1389 Modulation of the tumour promoting functions of cancer associated fibroblasts by phosphodiesterase type 5 inhibition increases the efficacy of chemotherapy in human preclinical models of esophageal adenocarcinoma.
Hayden, A.; Manousopoulou, A.; Cowie, A.; Walker, R.; Sharpe, B. P.; Harrington, J.; Izadi, F.; Kyle, E.; Saunders, J. H.; Parsons, S. L.; Ritchie, A. A.; Clarke, P. A.; Collier, P.; Garbis, S. D.; Rose-Zerilli, M.; Grabowska, A. M.; Underwood, T. J.
10.1101/2020.04.21.052647 — cancer biology — Posted on 2020-04-23
1390 Consistent trade-offs in ecosystem services between land covers with different production intensities
Gómez-Creutzberg, C.; Lagisz, M.; Nakagawa, S.; Brockerhoff, E. G.; Tylianakis, J. M.
10.1101/621706 — ecology — Posted on 2020-04-23
1391 Recellularization of bronchial extracellular matrix with primary bronchial smooth muscle cells
Ben Hamouda, S.; Vargas, A.; Boivin, R.; Miglino, M. A.; da Palma, R. K.; Lavoie, J.-P.
10.1101/2019.12.23.878645 — cell biology — Posted on 2020-04-23
1392 Molecular layer interneurons in the cerebellum encode for valence in associative learning
Ma, M.; Futia, G. L.; SIMOESDESOUZA, F.; Ozbay, B. N.; Llano, I.; Gibson, E. A.; Restrepo, D.
10.1101/2019.12.14.876201 — neuroscience — Posted on 2020-04-23
1393 Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspase-mediateddeath
Fisch, D.; Clough, B.; Domart, M.-C.; Encheva, V.; Bando, H.; Snijders, A. P.; Collinson, L. M.; Yamamoto, M.; Shenoy, A.; Frickel, E.-M.
10.1101/792804 — microbiology — Posted on 2020-04-23
1394 Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells
Dave, V.; Cardozo Ojeda, E. F.; Mair, F.; Erickson, J.; Woodward-Davis, A.; Soerens, A.; Koehne, A.; Czartoski, J.; Teague, C.; Potchen, N.; Oberle, S.; Zehn, D.; Schiffer, J.; Lund, J. M.; Prlic, M.
10.1101/769711 — immunology — Posted on 2020-04-23
1395 Cancer Classification from Blood-Derived DNA
Jain, S.; Mazaheri, B.; Raviv, N.; Bruck, J.
10.1101/517839 — genomics — Posted on 2020-04-23
1397 ESI mutagenesis: A one-step method for introducing point mutations into bacterial artificial chromosome transgenes
Rondelet, A.; Pozniakovsky, A.; Leuschner, M.; Poser, I.; Ssykor, A.; Berlitz, J.; Schmidt, N.; Hyman, A. A.; Bird, A. W.
10.1101/844282 — molecular biology — Posted on 2020-04-23
1398 Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels
McKennan, C.; Naughton, K.; Stanhope, C.; Kattan, M.; O'Connor, G.; Sandel, M.; Visness, C.; Wood, R.; Bacharier, L.; Beigelman, A.; Lovisky-Desir, S.; Togias, A.; Gern, J.; Nicolae, D.; Ober, C.
10.1101/339770 — genomics — Posted on 2020-04-23
1399 Transposable element landscape in Drosophila populations selected for longevity
Fabian, D. K.; Donertas, H. M.; Fuentealba Valenzuela, M.; Partridge, L.; Thornton, J. M.
10.1101/867838 — evolutionary biology — Posted on 2020-04-23
1400 Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle length
Tsuchiya, K.; Hayashi, H.; Nishina, M.; Okumura, M.; Sato, Y.; Kanemaki, M.; Goshima, G.; Kiyomitsu, T.
10.1101/473538 — cell biology — Posted on 2020-04-23
1402 GeTallele: a method for integrative analysis and visualization of DNA and RNA allele frequencies
Słowinski, P. M.; Li, M.; Restrepo, P.; Alomran, N.; Spurr, L.; Miller, C.; Tsaneva-Atanasova, K.; Horvath, A.
10.1101/491209 — bioinformatics — Posted on 2020-04-23
1403 Analysis of ongoing neuronal activity evoked by continuous speech with computational corpus linguistics methods
Schilling, A.; Tomasello, R.; Henningsen-Schomers, M. R.; Surendra, K.; Haller, M.; Karl, V.; Uhrig, P.; Maier, A.; Krauss, P.
10.1101/2020.04.21.052720 — neuroscience — Posted on 2020-04-23
1406 Rapid and cost-effective development of stable clones for the production of anti-Ebola monoclonal antibodies in HEK293T cells
Gonzalez-Gonzalez, E.; Palestino-Diaz, I.; Lopez-Pacheco, F.; Marquez-Ipiña, A. R.; Lara-Mayorga, I. M.; Trujillo-de Santiago, G.; Alvarez, M. M.
10.1101/2020.04.21.054429 — bioengineering — Posted on 2020-04-23
1409 Intrinsic/extrinsic duality of large-scale neural functional integration in the human brain
Sjogard, M.; Bourguignon, M.; Costers, L.; Dumitrescu, A.; Coolen, T.; Roshchupkina, L.; Destoky, F.; Bertels, J.; Niesen, M.; Vander Ghinst, M.; Van Schependom, J.; Nagels, G.; Urbain, C.; Peigneux, P.; Goldman, S.; Woolrich, M. W.; De Tiege, X.; Wens, V.
10.1101/2020.04.21.053579 — neuroscience — Posted on 2020-04-23
1410 Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients.
Furner-Pardoe, J.; Anonye, B. O.; Cain, R.; Moat, J.; Ortori, C. A.; Lee, C.; Barrett, D. A.; Corre, C.; Harrison, F.
10.1101/2020.04.21.052522 — microbiology — Posted on 2020-04-23
1413 Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation
Johnston, I.; Osborn, L. J.; McManus, E. A.; Kadam, A.; Schultz, K. B.; Ahern, P. A.; Brown, J. M.; Claesen, J.
10.1101/2020.04.22.055939 — microbiology — Posted on 2020-04-23
1414 Population genomics insights into the recent evolution of SARS-CoV-2
Vasilarou, M.; Alachiotis, N.; Garefalaki, J.; Beloukas, A.; Pavlidis, P.
10.1101/2020.04.21.054122 — evolutionary biology — Posted on 2020-04-23
1416 Targeted delivery of acid alpha-glucosidase corrects skeletal muscle phenotypes in Pompe disease mice
Baik, A. D.; Calafati, P. T.; Aaron, N. A.; Mehra, A.; Moller-Tank, S.; Miloscio, L.; Wang, L.; Praggastis, M.; Birnbaum, M. S.; Pan, C.; Brydges, S.; Mujica, A. O.; Barbounis, P.; Gale, N. W.; Li, N.; Kyratsous, C. A.; Schoenherr, C. J.; Murphy, A. J.; Economides, A. N.; Cygnar, K. D.
10.1101/2020.04.22.051672 — bioengineering — Posted on 2020-04-23
1419 Membrane estrogen receptor (GPER) and follicle-stimulating hormone receptor heteromeric complexes promote human ovarian follicle survival
Casarini, L.; Lazzaretti, C.; Paradiso, E.; Limoncella, S.; Riccetti, L.; Sperduti, S.; Melli, B.; Marcozzi, S.; Anzivino, C.; Sayers, N. S.; Czapinski, J.; Brigante, G.; Poti, F.; La Marca, A.; De Pascali, F.; Reiter, E.; Falbo, A.; Daolio, J.; Villani, M. T.; Lispi, M.; Orlando, G.; Klinger, F. G.; Fanelli, F.; Rivero-Müller, A.; Hanyaloglu, A. C.; Simoni, M.
10.1101/2020.04.21.053348 — physiology — Posted on 2020-04-23
1421 Changing color and intensity of LED lighting across the day impacts on human circadian physiology, sleep, visual comfort and cognitive performance
Stefani, O.; Freyburger, M.; Veitz, S.; Basishvili, T.; Meyer, M.; Weibel, J.; Kobayashi, K.; Shirakawa, Y.; Cajochen, C.
10.1101/2020.04.21.771832 — physiology — Posted on 2020-04-23
1422 Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport
McCauley, H. A.; Matthis, A. L.; Enriquez, J. R.; Nichol, J.; Sanchez, J. G.; Stone, W. J.; Sundaram, N.; Helmrath, M. A.; Montrose, M. H.; Aihara, E.; Wells, J. M.
10.1101/2020.04.21.053363 — physiology — Posted on 2020-04-23
1425 Weight Sensitivity of Temporal SNR Metrics in multi-echo fMRI
Liu, T.; Li, B.; Chen, C.; Fernandez, B.; Yang, B.; Banerjee, S.
10.1101/2020.04.20.049460 — neuroscience — Posted on 2020-04-23
1428 FAM111A regulates replication origin activation and cell fitness
Rios-Szwed, D. O.; Garcia-Wilson, E.; Sanchez-Pulido, L.; Alvarez, V.; Jiang, H.; Bandau, S.; Lamond, A.; Ponting, C.; Alabert, C.
10.1101/2020.04.22.055574 — molecular biology — Posted on 2020-04-23
1431 Glycomic analysis of host-response reveals high mannose as a key mediator of influenza severity
Heindel, D. W.; Koppolu, S.; Zhang, Y.; Kasper, B.; Meche, L.; Vaiana, C. A.; Bissel, S.; Carter, C. E.; Kelvin, A. A.; Zhang, B.; Zhou, B.; Chu, T.-W.; Lashua, L. P.; Ross, T.; Ghedin, E.; Mahal, L. K.
10.1101/2020.04.21.054098 — microbiology — Posted on 2020-04-23
1437 The anticoagulant nafamostat potently inhibits SARS-CoV-2 infection in vitro: an existing drug with multiple possible therapeutic effects
Yamamoto, M.; Kiso, M.; Sakai-Tagawa, Y.; Iwatsuki-Horimoto, K.; Imai, M.; Takeda, M.; Kinoshita, N.; Ohmagari, N.; Gohda, J.; Semba, K.; Matsuda, Z.; Kawaguchi, Y.; Kawaoka, Y.; Inoue, J.-i.
10.1101/2020.04.22.054981 — microbiology — Posted on 2020-04-23
1438 Insights into the role of C3d dimers in B cell activation and Staphylococcal immune evasion
Wahid, A. A.; Dunphy, R. W.; Macpherson, A.; Gibson, B. G.; Kulik, L.; Whale, K.; Back, C. R.; Hallam, T. M.; Alkhawaja, B.; Martin, R. L.; Meschede, I. P.; Lawson, A. D. G.; Holers, V. M.; Watts, A. G.; Crennell, S. J.; Harris, C. L.; Marchbank, K. J.; van den Elsen, J. M. H.
10.1101/2020.04.22.054700 — immunology — Posted on 2020-04-23
1439 Cancer cell elimination by cytotoxic T cell cooperation and additive damage
Weigelin, B.; den Boer, A. T.; Wagena, E.; Broen, K.; Dolstra, H.; de Boer, R. J.; Figdor, C. G.; Textor, J.; Friedl, P.
10.1101/2020.04.22.054718 — immunology — Posted on 2020-04-23
1442 Half of the world's tree biodiversity is unprotected and is increasingly threatened by human activities
Guo, W.-Y.; Serra-Diaz, J. M.; Schrodt, F.; Eiserhardt, W. L.; Maitner, B. S.; Merow, C.; Violle, C.; Anand, M.; Belluau, M.; Bruun, H. H.; Byun, C.; Catford, J. A.; Cerabolini, B. E. L.; Chacon-Madrigal, E.; Ciccarelli, D.; Cornelissen, J. H. C.; Dang-Le, A. T.; de Frutos, A.; Dias, A. S.; Giroldo, A. B.; Guo, K.; Gutierrez, A. G.; Hattingh, W.; He, T.; Hietz, P.; Hough-Snee, N.; Jansen, S.; Kattge, J.; Klein, T.; Komac, B.; Kraft, N.; Kramer, K.; Lavorel, S.; Lusk, C. H.; Martin, A. R.; Mencuccini, M.; Michaletz, S. T.; Minden, V.; Mori, A. S.; Niinemets, U.; Onoda, Y.; Onstein, R. E.; Penue
10.1101/2020.04.21.052464 — ecology — Posted on 2020-04-23
1443 Iterative inhibition of commissural growth cone exploration, not post-crossing barrier, ensures forward midline navigation through SlitC-PlxnA1 signaling
Ducuing, H.; Gardette, T.; Pignata, A.; Kindbeiter, K.; Bozon, M.; Thoumine, O.; Delloye-Bourgeois, C.; Tauszig-Delamasure, S.; Castellani, V.
10.1101/2020.04.21.051359 — developmental biology — Posted on 2020-04-23
1445 Unveiling cells' local environment during cryopreservation by correlative in situ spatial and thermal analyses
Qin, K.; Eschenbrenner, C.; Ginot, F.; Dedovets, D.; Coradin, T.; Deville, S.; Fernandes, F. M.
10.1101/2020.04.21.052696 — biophysics — Posted on 2020-04-23
1446 Reference-free and de novo Identification of Circular RNAs
Qin, Y.; Xu, T.; Lin, W.; Jia, Q.; He, Q.; Liu, K.; Du, J.; Chen, L.; Yang, X.; Du, F.; Li, M.; Chen, M.; Tao, T.; Ji, Z.-L.
10.1101/2020.04.21.050617 — bioinformatics — Posted on 2020-04-23
1449 Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes
Montemayor, E. J.; Virta, J. M.; Hayes, S. M.; Nomura, Y.; Brow, D. A.; Butcher, S. E.
10.1101/2020.04.22.055376 — biochemistry — Posted on 2020-04-23
1450 Exploration of natural red-shifted rhodopsins using a machine learning-based Bayesian experimental design
Inoue, K.; Karasuyama, M.; Nakamura, R.; Konno, M.; Yamada, D.; Mannen, K.; Nagata, T.; Inatsu, Y.; Yura, K.; Beja, O.; Kandori, H.; Takeuchi, I.
10.1101/2020.04.21.052548 — biochemistry — Posted on 2020-04-23
1452 Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity
Xu, Q.; Zhang, S.-S.; Pei, Y.-F.; Ni, J.-J.; Zhang, L.; Wang, R.-R.; Weng, Y.-J.; Cui, X.; Wei, X.-T.
10.1101/2020.04.20.052407 — genomics — Posted on 2020-04-23
1453 IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation
Pan, L.; Lemieux, M. E.; Thomas, T.; Rogers, J. M.; Lee, W.; Johnson, C.; Sholl, L.; South, A. P.; Marto, J. A.; Adelmant, G. O.; Blacklow, S. C.; Aster, J. C.
10.1101/2020.04.21.051730 — cancer biology — Posted on 2020-04-23
1456 PanGIA: A Metagenomics Analytical Framework for RoutineBiosurveillance and Clinical Pathogen Detection
Li, P.-E.; Russell, J. A.; Yarmosh, D.; Shteyman, A. G.; Parker, K.; Wood, H.; Aspinwall, J. R.; Winegar, R.; Davenport, K. W.; Lo, C.-C.; Bagnoli, J.; Davis, P. E.; Jacobs, J. L.; Chain, P.
10.1101/2020.04.20.051813 — bioinformatics — Posted on 2020-04-23
1461 Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors
Fellner, M.; Lentz, C. S.; Jamieson, S. A.; Brewster, J. L.; Chen, L.; Bogyo, M.; Mace, P. D.
10.1101/2020.04.21.054437 — biochemistry — Posted on 2020-04-23
1462 Structural Basis of CD4 Downregulation by HIV-1 Nef
Kwon, Y.; Kaake, R.; Echeverria, I.; Suarez, M.; Stoneham, C.; Ramirez, P. W.; Kress, J.; Singh, R.; Sali, A.; Krogan, N. J.; Guatelli, J.; Jia, X.
10.1101/2020.04.21.054007 — biochemistry — Posted on 2020-04-23
1470 Social Stress Alters Immune Response and Results in Higher Viral Load During Acute SIV Infection in a Pigtailed Macaque Model of HIV
Guerrero-Martin, S. M.; Rubin, L. H.; Mcgee, K. M.; Shirk, E. N.; Queen, S. E.; Li, M.; Bullock, B.; Carlson, B. W.; Adams, R. J.; Gama, L.; Graham, D.; Zink, C.; Clements, J. E.; Mankowski, J. L.; Metcalf Pate, K. A.
10.1101/2020.04.21.054130 — microbiology — Posted on 2020-04-23
1471 Candida auris phenotypic heterogeneity determines pathogenicity in vitro
Brown, J. L.; Delaney, C.; Short, B.; Butcher, M. C.; McKloud, E.; Williams, C.; Kean, R.; Ramage, G.
10.1101/2020.04.20.052399 — microbiology — Posted on 2020-04-23
1474 Complementation can maintain a quasispecies of drug sensitive and resistant HIV
Jackson, L.; Cele, S.; Lustig, G.; Giandhari, J.; de Oliveira, T.; Neher, R.; Sigal, A.
10.1101/2020.04.20.051854 — evolutionary biology — Posted on 2020-04-23
1477 Spectral DQE of the Volta Phase Plate
Buijsse, B.; Trompenaars, P.; Altin, V.; Danev, R.; Glaeser, R.
10.1101/2020.04.20.046110 — bioengineering — Posted on 2020-04-23
1478 Fruit bromelain derived peptides destabilize growth of amyloidal fibrils
Das, S.; Dutta, S.; Paidi, R. K.; Biswas, S. C.; Halder, U. C.; Bhattacharyya, D.
10.1101/2020.04.20.051193 — biochemistry — Posted on 2020-04-23
1480 Chronic consumption of alcohol increase alveolar bone loss
De Almeida, J. M.; Pazmino, V. F. C.; novaes, v.; Bomfim, S. R. M.; Nagata, M. J. H.; De Oliveira, F. L. P.; Ervolino, E.
10.1101/2020.04.22.055186 — pathology — Posted on 2020-04-22
1482 Seasonal weight changes in laboratory ferrets
Jones, E. J.; Poole, K.; Sollini, J.; Town, S. M.; Bizley, J. K.
10.1101/2020.04.22.055194 — neuroscience — Posted on 2020-04-22
1485 Astrocytes and neurons share brain region-specific transcriptional signatures
Herrero-Navarro, A.; Puche-Aroca, L.; Moreno-Juan, V.; Sempere-Ferrandez, A.; Espinosa, A.; Susin, R.; Torres-Masjoan, L.; Leyva-Diaz, E.; Karow, M.; Figueres-Onate, M.; Lopez-Mascaraque, L.; Lopez-Atalaya, J. P.; Berninger, B.; Lopez-Bendito, G.
10.1101/2020.04.21.038737 — neuroscience — Posted on 2020-04-22
1490 Defining Epidermal Stem Cell Fate Infidelity and Immunogenicity in Hidradenitis Suppurativa at the Single-Cell Resolution
Marohn, M.; Lin, M.-j.; Yu, W.-w.; Mendoza, C. M.; Remark, J.; Khodadadi-Jamayran, A.; Chiu, E. S.; Lu, C. P.-J.
10.1101/2020.04.21.053611 — cell biology — Posted on 2020-04-22
1494 Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition
Bertels, Z.; Grewal, H.; Dripps, I.; Siegersma, K.; Laboy, A.; Witkowski, W.; Sheets, Z.; Shah, P.; Conway, C.; Petukhova, V.; Karumudi, B.; Petukhov, P. A.; Baca, S. M.; Rasenick, M. M.; Pradhan, A. A.
10.1101/2020.04.21.053272 — neuroscience — Posted on 2020-04-22
1500 The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions
Kim, J. B.; Zhao, Q.; Nguyen, T.; Pjanic, M.; Cheng, P.; Wirka, R.; Travisano, S.; Nagao, M.; Kundu, R.; Quertermous, T.
10.1101/2020.04.21.049890 — genomics — Posted on 2020-04-22
1501 Nicotinamide promotes differentiation of pancreatic endocrine progenitors from human pluripotent stem cells through poly (ADP-ribose) polymerase inhibition
Woodford, C.; Yin, T.; Chang, H. H.; Regeenes, R.; Vellanki, R. N.; Mohan, H.; Wouters, B. G.; Rocheleau, J. V.; Wheeler, M. B.; Zandstra, P. W.
10.1101/2020.04.21.052951 — developmental biology — Posted on 2020-04-22
1502 Human iPSC-derived cerebral organoids model features of Leigh Syndrome and reveal abnormal corticogenesis
Romero-Morales, A. I.; Rastogi, A.; Temuri, H.; Rasmussen, M. L.; McElroy, G. S.; Hsu, L.; Almonacid, P. M.; Millis, B. A.; Chandel, N. S.; Cartailler, J.-P.; Gama, V.
10.1101/2020.04.21.054361 — cell biology — Posted on 2020-04-22
1503 Hyperexcitability and loss of feedforward inhibition in the Fmr1KO lateral amygdala.
Guthman, E. M.; Svalina, M. N.; Cea-Del Rio, C. A.; Kushner, J. K.; Baca, S. M.; Restrepo, D.; Huntsman, M. M.
10.1101/2020.04.21.053652 — neuroscience — Posted on 2020-04-22
1505 Multi-parametric analysis of 58 SYNGAP1 variants reveal impacts on GTPase signaling, localization and protein stability
Meili, F.; Wei, W. J.; Sin, W.-C.; Dascalu, I.; Callaghan, D. B.; Rogic, S.; Meyers, W. M.; Pavlidis, P.; Haas, K.
10.1101/2020.04.21.053686 — genetics — Posted on 2020-04-22
1507 Role of c-Met/β1 integrin complex in the metastatic cascade
Lau, D.; Wadhwa, H.; Sudhir, S.; Jain, S.; Chandra, A.; Nguyen, A.; Spatz, J.; Shah, S. S.; Cheng, J.; Safaee, M.; Yagnik, G.; Jahangiri, A.; Aghi, M. K.
10.1101/2020.04.20.051888 — cancer biology — Posted on 2020-04-22
1509 UMI-VarCal: a new UMI-based variant caller that efficiently improves low-frequency variant detection in paired-end sequencing NGS libraries
Sater, V.; Viailly, P.-J.; Lecroq, T.; Prieur-Gaston, E.; Bohers, E.; Viennot, M.; Ruminy, P.; Dauchel, H.; Vera, P.; Jardin, F.
10.1101/775817 — bioinformatics — Posted on 2020-04-22
1510 Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Butler, D. J.; Mozsary, C.; Meydan, C.; Danko, D. C.; Foox, J.; Rosiene, J.; Shaiber, A.; Afshinnekoo, E.; MacKay, M.; Sedlazeck, F. J.; Ivanov, N. A.; Sierra, M. A.; Pohle, D.; Zeitz, M.; Ramlall, V.; Gisladottir, U.; Westover, C. D.; Ryon, K.; Young, B.; Bhattacharya, C.; Ruggiero, P.; Langhorst, B. W.; Tanner, N. A.; Gawrys, J.; Meleshko, D.; Xu, D.; Xiang, J.; Iftner, A.; Bezdan, D.; Sipley, J.; Cong, L.; Craney, A.; Velu, P.; Melnick, A.; Hajirasouliha, I. A.; Iftner, T.; Salvatore, M.; Loda, M.; Westblade, L. F.; Levy, S.; Cushing, M.; Tatonetti, N. P.; Imielinski, M.; Rennert, H.; Mason
10.1101/2020.04.20.048066 — molecular biology — Posted on 2020-04-22
1511 Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Williamson, B.; Feldmann, F.; Schwarz, B.; Meade-White, K.; Porter, D.; Schulz, J.; van Doremalen, N.; Leighton, I.; Yinda, C. K.; Perez-Perez, L.; Okumura, A.; Lovaglio, J.; Hanley, P.; Saturday, G.; Bosio, C.; Anzick, S.; Barbian, K.; Chilar, T.; Martens, C.; Scott, D.; Munster, V.; de Wit, E.
10.1101/2020.04.15.043166 — microbiology — Posted on 2020-04-22
1512 Identifying Novel Drug and Vaccine Molecules of Vibrio parahaemolyticus by Subtractive Proteomics and Vaccinomics Approach
Hasan, M.; Azim, K. F.; Imran, A. S.; Chowdhury, I. M.; Urme, S. R. A.; Parvez, M. S. A.; Uddin, M. B.; Ahmed, S. S. U.
10.1101/2020.04.17.045849 — microbiology — Posted on 2020-04-22
1513 Structural analysis of SARS-CoV-2 and predictions of the human interactome
Vandelli, A.; Monti, M.; Milanetti, E.; Rupert, J.; Zacco, E.; Bechara, E.; Delli Ponti, R.; Tartaglia, G. G.
10.1101/2020.03.28.013789 — bioinformatics — Posted on 2020-04-22
1514 Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of SARS-CoV-2 entry
Mei, Z.; Bingpeng, L.; Hongbin, G.; Xinhong, W.; Chang, L.; Kaibin, W.; Mingxiao, L.; Jianming, C.; Jiang-yong, H.; Learn-han, L.; Cuiling, Q.; Linhu, G.; Lijing, W.
10.1101/2020.04.18.047951 — pathology — Posted on 2020-04-22
1516 The transcription regulatory code of a maize leaf
Tu, X.; Mejia Guerra, M. K.; Franco, J. A. V.; Tzeng, D.; Chu, P.-Y.; Dai, X.; Li, P.; Buckler, E. S.; Zhong, S.
10.1101/2020.01.07.898056 — molecular biology — Posted on 2020-04-22
1517 G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
Prentzell, M. T.; Rehbein, U.; Cadena Sandoval, M.; De Meulemeester, A.-S.; Baumeister, R.; Brohee, L.; Berdel, B.; Bockwoldt, M.; Carroll, B.; von Deimling, A.; Demetriades, C.; Figlia, G.; Heberle, A. M.; Heiland, I.; Holzwarth, B.; Huber, L. A.; Jaworski, J.; Kern, K.; Kopach, A.; Korolchuk, V. I.; van 't Land-Kuper, I.; Macias, M.; Nellist, M.; Pusch, S.; Reil, M.; Reintjes, A.; Reuter, F.; Scheldeman, C.; Stefan, E.; Teleman, A.; Torres-Quesada, O.; Trump, S.; de Witte, P.; Yordanov, T.; Opitz, C. A.; Thedieck, K.
10.1101/2020.04.16.044081 — cell biology — Posted on 2020-04-22
1518 Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
Dentro, S. C.; Leshchiner, I.; Haase, K.; Tarabichi, M.; Wintersinger, J.; Deshwar, A. G.; Yu, K.; Rubanova, Y.; Macintyre, G.; Demeulemeester, J.; Vazquez-Garcia, I.; Kleinheinz, K.; Livitz, D. G.; Malikic, S.; Donmez, N.; Sengupta, S.; Anur, P.; Jolly, C.; Cmero, M.; Rosebrock, D.; Schumacher, S.; Fan, Y.; Fittall, M.; Drews, R. M.; Yao, X.; Lee, J.; Schlesner, M.; Zhu, H.; Adams, D. J.; Getz, G.; Boutros, P. C.; Imielinski, M.; Beroukhim, R.; Sahinalp, S. C.; Ji, Y.; Peifer, M.; Martincorena, I.; Markowetz, F.; Mustonen, V.; Yuan, K.; Gerstung, M.; Spellman, P. T.; Wang, W.; Morris, Q. D.;
10.1101/312041 — cancer biology — Posted on 2020-04-22
1519 Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer
Mao, C.; Shen, C.; Li, C.; Shen, D.-D.; Xu, C.-J.; Zhang, S.; Zhou, R.; Shen, Q.; Chen, L.-N.; Jiang, Z.; Liu, j.; Zhang, Y.
10.1101/2020.04.21.053488 — molecular biology — Posted on 2020-04-22
1520 REVEALING COVID-19 TRANSMISSION BY SARS-CoV-2 GENOME SEQUENCING AND AGENT BASED MODELLING
Rockett, R. J.; Arnott, A.; Lam, C.; Sadsad, R.; Timms, V.; Gray, K.-A.; Eden, J.-S.; Chang, S. L.; Gall, M.; Draper, J.; Sim, E.; Bachmann, N. L.; Carter, I.; Basile, K.; Byun, R.; O Sullivan, M. V.; Chen, S. C.-A.; Maddocks, S.; Sorrell, T. C.; Dwyer, D. E.; Holmes, E. C.; Kok, J.; Prokopenko, M.; Sintchenko, V.
10.1101/2020.04.19.048751 — microbiology — Posted on 2020-04-22
1522 Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease
Youlten, S. E.; Kemp, J. P.; Logan, J. G.; Ghirardello, E. J.; Sergio, C. M.; Dack, M. R. G.; Guilfoyle, S. E.; Leitch, V. D.; Butterfield, N. C.; Komla-Ebri, D.; Chai, R. C.; Corr, A. P.; Smith, J. T.; Morris, J. A.; McDonald, M. M.; Quinn, J. M. W.; McGlade, A. R.; Bartonicek, N.; Jansson, M.; Hatzikotoulas, K.; Irving, M. D.; Beleza-Meireles, A.; Rivadeneira, F.; Duncan, E. L.; Richards, J. B.; Adams, D. J.; Lelliott, C. J.; Brink, R.; Phan, T. G.; Eisman, J. A.; Evans, D. M.; Zeggini, E.; Baldock, P. A.; Bassett, J. H. D.; Williams, G. R.; Croucher, P. I.
10.1101/2020.04.20.051409 — systems biology — Posted on 2020-04-22
1523 Cellbow: a robust customizable cell segmentation program
Ren, H.; Zhao, M.; Liu, B.; Yao, R.; Liu, Q.; Ren, Z.; Wu, Z.; Gao, Z.; Yang, X.; Tang, C.
10.1101/2020.04.21.052597 — systems biology — Posted on 2020-04-22
1524 Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications
Whitbeck, J. C.; Thomas, A.; Kadash-Edmondson, K.; Grinyo i Escuer, A.; Cheng, C.; Liao, G. C.; Holtsberg, F. W.; Aman, M. J.; Simmons, G.; Davidson, E.; Doranz, B. J.
10.1101/2020.04.21.047241 — microbiology — Posted on 2020-04-22
1525 Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes
Sano, T.; Kageyama, T.; Fang, V.; Kedmi, R.; Talbot, J.; Chen, A.; Kurakake, R.; Yang, Y.; Ng, C.; Schwab, S. R.; Littman, D. R.
10.1101/2020.04.21.053934 — immunology — Posted on 2020-04-22
1527 TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome
Zimmerli, D.; Borrelli, C.; Jauregi-Miguel, A.; Söderholm, S.; Brütsch, S.; Doumpas, N.; Reichmuth, J.; Murphy-Seiler, F.; Aguet, M.; Basler, K.; Moor, A. E.; Cantu, C.
10.1101/2020.04.22.053561 — developmental biology — Posted on 2020-04-22
1528 Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.
Hari-Gupta, Y.; Fili, N.; dos Santos, A.; Cook, A. W.; Gough, R. E.; Reed, H. C. W.; Wang, L.; Arron, J.; Venit, T.; Waite, E.; Grosse-Berkenbusch, A.; Gebhardt, J. C. M.; Percipalle, P.; Chew, T. L.; Martin-Fernandez, M. L.; Toseland, C. P.
10.1101/2020.04.21.053124 — cell biology — Posted on 2020-04-22
1529 Prediction of novel components of bacterial ribosomes by crowd-sourced analysis of RNA sequencing data
mtwil, m.; Koh, K.; Goh, W.; Tan, Q. W.; Rugdee, R. C. F.; Hew, B.; Ng, J. W. X.; Teng, Z. K.; Tan, J. X.; Yei, X.; Tan, Q. R.; Binte Sulaiman, I. S.; Gilia, S. M. L.; Villanueva, E. M. F.; Nguyen, S. T.; Putri, D. A.; Siying, J. T.; Johanan, T. Y. R.; Tan, J. W.; Gladys, K. S. N.; Ong, W. W.; Moo, J. R.; Koh, J.; Lim, P. X.; Teoh, S. W.; Tamilselvam, P.; Hui, H.; Chua, Y. X.; Ow Yeong, Y. K.; Jian Hua, T.; Chong, M. J.; Sho, Y. W.; Tang, B. J. X.; Kwantalalu, C. Y.; Binte Mohammad Rizal, N. A.; Tan, W. H.; Shan Chun, L.; Tan, S. Y. T.; Jia Ying, T.; Luminary, A. M.; Jia Jia, Jolyn, L.; Lunard
10.1101/2020.04.20.005249 — bioinformatics — Posted on 2020-04-22
1530 Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemia
Wang, T.; Pine, A. R.; Wesely, J.; Yuan, H.; Zamparo, L.; Kotini, A. G.; Leslie, C. S.; Papapetrou, E. P.
10.1101/2020.04.21.051961 — cancer biology — Posted on 2020-04-22
1533 Sensory-evoked extracellular vesicle release and targeting
Wang, J.; Nikonorova, I. A.; Gu, A.; Sternberg, P. W.; Barr, M. M.
10.1101/2020.04.21.050690 — cell biology — Posted on 2020-04-22
1534 A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules
Karki, M.; Jangid, R. K.; Seervai, R. N. H.; Bertocchio, J.-P.; Hotta, T.; Msaouel, P.; Jung, S. Y.; Grimm, S. L.; Coarfa, C.; Weissman, B. E.; Ohi, R.; Verhey, K. J.; Hodges, C. H.; Dere, R.; Park, I.-Y.; Rathmell, K. W.; Walker, C. L.; Tripathi, D. N.
10.1101/2020.04.21.053942 — cell biology — Posted on 2020-04-22
1537 ILC1-derived TGFβ1 drives intestinal remodelling
Jowett, G. M.; Norman, M. D. A.; Yu, T. T. L.; Rosell Arevalo, P.; Hoogland, D.; Lust, S.; Read, E.; Hamrud, E.; Walters, N. J.; Niazi, U.; Chung, M. W. H.; Marciano, D.; Omer, O. S.; Zabinski, T.; Danovi, D.; Lord, G. M.; Hilborn, J.; Evans, N.; Dreiss, C. A.; Bozec, L.; Oomen, O. P.; Lorenz, C. D.; da Silva, R. M. P.; Neves, J. F.; Gentleman, E.
10.1101/2020.04.20.051805 — immunology — Posted on 2020-04-22
1539 Structural Basis of SARS-CoV-2 Spike Protein Priming by TMPRSS2
Hussain, M.; Jabeen, N.; Amanullah, A.; Baig, A. A.; Aziz, B.; Shabbir, S.; Raza, F.
10.1101/2020.04.21.052639 — bioinformatics — Posted on 2020-04-22
1541 Tendon and Motor Phenotypes in the Crtap-/- Mouse Model of Recessive Osteogenesis Imperfecta
Grol, M. W.; Haelterman, N. A.; Munivez, E. M.; Archer, M.; Hudson, D.; Tufa, S. F.; Keene, D. R.; Eyre, D.; Lee, B. H.
10.1101/2020.04.21.048488 — genetics — Posted on 2020-04-22
1544 Pattern-recognition receptors are required for NLR-mediated plant immunity
Yuan, M.; Jiang, Z.; Bi, G.; Nomura, K.; Liu, M.; He, S. Y.; Zhou, J.-M.; Xin, X.-F.
10.1101/2020.04.10.031294 — plant biology — Posted on 2020-04-22
1550 Dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting
Leon-Sampedro, R.; DelaFuente, J.; Diaz-Agero, C.; Crellen, T.; Musicha, P.; Rodriguez-Beltran, J.; de la Vega, C.; Hernandez-Garcia, M.; Lopez-Fresnena, N.; Ruiz-Garbajosa, P.; Canton, R.; Cooper, B. S.; San Millan, A.
10.1101/2020.04.20.050476 — microbiology — Posted on 2020-04-22
1552 Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitis
Friedrich, V.; Forne, I.; Matzek, D.; Ring, D.; Popper, B.; Jochum, L.; Spriewald, S.; Straub, T.; Imhof, A.; Krug, A.; Stecher, B.; Brocker, T.
10.1101/2020.04.21.053066 — immunology — Posted on 2020-04-22
1555 Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
Pinto-Fernandez, A.; Salio, M.; Partridge, T.; Chen, J.; Vere, G.; Greenwood, H.; Olie, C. S.; Damianou, A.; Scott, H. C.; Pegg, H. J.; Chiarenza, A.; Diaz-Saez, L.; Smith, P.; Gonzalez-Lopez, C.; Patel, B.; Anderton, E.; Jones, N.; Hammonds, T. R.; Huber, K.; Muschel, R.; Borrow, P.; Cerundolo, V.; Kessler, B. M.
10.1101/2020.03.31.005629 — cancer biology — Posted on 2020-04-22
1558 Testosterone signaling through ZIP9 renders melanoma more aggressive in males than in females
Aguirre-Portoles, C.; Payne, R.; Trautz, A.; Foskett, J. K.; Natale, C. A.; Ridky, T. W.
10.1101/2020.03.12.989160 — cancer biology — Posted on 2020-04-21
1561 Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, northern Tanzania
Mziray, S. R.; Kumburu, H. H.; Assey, H. B.; Sonda, T. B.; Mahande, M. J.; Msuya, S. E.; Kiwelu, I. E.
10.1101/2020.04.21.052902 — genomics — Posted on 2020-04-21
1562 Inhibition of PIKfyve kinase prevents infection by EBOV and SARS-CoV-2
Kang, Y.-L.; Chou, Y.-Y.; Rothlauf, P. W.; Liu, Z.; Piccinotti, S.; Soh, T. K.; Cureton, D.; Case, J. B.; Chen, R. E.; Diamond, M. S.; Whelan, S. P. J.; Kirchhausen, T.
10.1101/2020.04.21.053058 — cell biology — Posted on 2020-04-21
1563 Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2: toward universal blueprints for vaccine designs
Malone, B.; Simovski, B.; Moline, C.; Cheng, J.; Gheorghe, M.; Fontenelle, H.; Vardaxis, I.; Tennoe, S.; Malmberg, J.-A.; Stratford, R.; Clancy, T.
10.1101/2020.04.21.052084 — bioinformatics — Posted on 2020-04-21
1565 No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes
Baratchian, M.; McManus, J.; Berk, M.; Nakamura, F.; Erzurum, S.; Mukhopadhyay, S.; Drazba, J.; Peterson, J.; Gaston, B.; Sharifi, N.
10.1101/2020.04.21.051201 — physiology — Posted on 2020-04-21
1566 A Scalable, Easy-to-Deploy, Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material
Rauch, J. N.; Valois, E.; Solley, S. C.; Braig, F.; Lach, R. S.; Baxter, N. J.; Kosik, K. S.; Arias, C.; Acosta-Alvear, D.; Wilson, M. Z.
10.1101/2020.04.20.052159 — molecular biology — Posted on 2020-04-21
1567 Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases
Walker, A.; Fan, H.; Keown, J. R.; Margitich, V.; Grimes, J. M.; Fodor, E.; te Velthuis, A. J.
10.1101/2020.04.21.053017 — microbiology — Posted on 2020-04-21
1570 Subthreshold repertoire and threshold dynamics of midbrain dopamine neuron firing in vivo
Otomo, K.; Perkins, J.; Kulkarni, A.; Stojanovic, S.; Roeper, J.; Paladini, C. A.
10.1101/2020.04.06.028829 — neuroscience — Posted on 2020-04-21
1576 β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes
Hattori, K.; Wakatsuki, H.; Sakauchi, C.; Furutani, S.; Hatta, T.; Natsume, T.; Ichijo, H.
10.1101/2020.04.21.052985 — molecular biology — Posted on 2020-04-21
1577 A facile method of mapping neutralizing HIV-1 epitopes
Datta, R.; Roy Chowdhury, R.; Manjunath, K.; Hanna, L. E.; Varadarajan, R.
10.1101/2020.04.15.041996 — molecular biology — Posted on 2020-04-21
1581 The Hrq1 helicase stimulates Pso2 translesion nuclease activity to promote DNA inter-strand crosslink repair
Rogers, C. M.; Lee, C.-Y.; Parkins, S.; Buehler, N. J.; Wenzel, S.; Martinez-Marquez, F.; Takagi, Y.; Myong, S.; Bochman, M. L.
10.1101/773267 — biochemistry — Posted on 2020-04-21
1584 A thymus tumour impairing hibernation
Markussen, F. A. S.; Melum, V. J.; Bothorel, B.; Hazlerigg, D. G.; Simonneaux, V.; Wood, S. H.
10.1101/2020.04.20.009712 — physiology — Posted on 2020-04-21
1585 The haemodynamics of the human placenta in utero
Dellschaft, N. S.; Hutchinson, G.; Shah, S.; Jones, N. W.; Bradley, C.; Leach, L.; Platt, C.; Bowtell, R.; Gowland, P.
10.1101/2020.02.07.938589 — physiology — Posted on 2020-04-21
1586 Interferon-gamma signalling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes
Warre Cornish, K.; Perfect, L.; Nagy, R.; Duarte, R. R.; Reid, M. J.; Raval, P.; Mueller, A.; Evans, A.; Couch, A.; Ghevaert, C.; McAlonan, G.; Loth, E.; Murphy, D.; Powell, T. R.; Vernon, A. C.; Srivastava, D. P.; Price, J.
10.1101/789321 — neuroscience — Posted on 2020-04-21
1591 Rapid, field-deployable nucleobase detection and identification using FnCas9
Azhar, M.; Phutela, R.; Ansari, A. H.; Sinha, D.; Sharma, N.; Kumar, M.; Aich, M.; Sharma, S.; Singhal, K.; Lad, H.; Patra, P. K.; Makharia, G.; Chandak, G. R.; Chakraborty, D.; Maiti, S.; Rauthan, R.
10.1101/2020.04.07.028167 — molecular biology — Posted on 2020-04-21
1595 How do invasion syndromes evolve? An experimental evolution approach using the ladybird Harmonia axyridis
Foucaud, J.; Hufbauer, R. A.; Ravigne, V.; Olazcuaga, L.; Loiseau, A.; Ausset, A.; Wang, S.; Zang, L.-S.; Lemenager, N.; Tayeh, A.; Weyna, A.; Gneux, P.; Bonnet, E.; Dreuilhe, V.; Poutout, B.; Estoup, A.; Facon, B.
10.1101/849968 — evolutionary biology — Posted on 2020-04-21
1597 BiCoN: Network-constrained biclustering of patients and omics data
Lazareva, O.; Van Do, H.; Canzar, S.; Yuan, K.; Baumbach, J.; Blumenthal, D. B.; Tieri, P.; Kacprowski, T.; List, M.
10.1101/2020.01.31.926345 — bioinformatics — Posted on 2020-04-21
1601 Efficient data management infrastructure for the integration of imaging and omics data in life science research
Kuhn Cuellar, L.; Friedrich, A.; Gabernet, G.; de la Garza, L.; Fillinger, S.; Seyboldt, A.; zur Oven-Krockhaus, S.; Wanke, F.; Richter, S.; Thaiss, W. M.; Horger, M.; Malek, N.; Harter, K.; Bitzer, M.; Nahnsen, S.
10.1101/2019.12.28.889295 — bioinformatics — Posted on 2020-04-21
1603 Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Muus, C.; Luecken, M. D.; Eraslan, G.; Waghray, A.; Heimberg, G.; Sikkema, L.; Kobayashi, Y.; Vaishnav, E. D.; Subramanian, A.; Smillie, C.; Jagadeesh, K.; Duong, E. T.; Fiskin, E.; Torlai Triglia, E.; Becavin, C.; Ansari, M.; Cai, P.; Lin, B.; Buchanan, J.; Chen, S.; Shu, J.; Haber, A. L.; Chung, H.; Montoro, D. T.; Adams, T.; Aliee, H.; Allon, S. J.; Andrusivova, Z.; Angelidis, I.; Ashenberg, O.; Bassler, K.; Becavin, C.; Benhar, I.; Bergenstrahle, J.; Bergenstrahle, L.; Bolt, L.; Braun, E.; Bui, L. T.; Chaffin, M.; Chichelnitskiy, E.; Chiou, J.; Conlon, T. M.; Cuoco, M. S.; Deprez, M.; Fisc
10.1101/2020.04.19.049254 — bioinformatics — Posted on 2020-04-21
1605 Serotonin and childhood maltreatment interact to shape brain architecture and anxious avoidant behavior, a TPH2 imaging genetics approach
Liu, C.; Xu, L.; Li, J.; Zhou, F.; Yang, X.; Zheng, X.; Fu, M.; Li, K.; Sindermann, C.; Montag, C.; Ma, Y.; Scheele, D.; Ebstein, R. P.; Yao, S.; Kendrick, K. M.; Becker, B.
10.1101/685099 — neuroscience — Posted on 2020-04-21
1606 Removal of high frequency contamination from motion estimates in single-band fMRI saves data without biasing functional connectivity
Gratton, C.; Dworetsky, A.; Coalson, R. S.; Adeyemo, B.; Laumann, T. O.; Wig, G. S.; Kong, T. S.; Gratton, G.; Fabiani, M.; Barch, D. M.; Tranel, D.; Miranda-Dominguez, O.; Fair, D. A.; Dosenbach, N. U. F.; Snyder, A. Z.; Perlmutter, J. S.; Petersen, S. E.; Campbell, M. C.
10.1101/837161 — neuroscience — Posted on 2020-04-21
1612 GeTallele: a method for integrative analysis and visualization of DNA and RNA allele frequencies
Słowinski, P. M.; Li, M.; Restrepo, P.; Alomran, N.; Spurr, L.; Miller, C.; Tsaneva-Atanasova, K.; Horvath, A.
10.1101/491209 — bioinformatics — Posted on 2020-04-21
1616 Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons
Lindhout, F. W.; Kooistra, R.; Portegies, S.; Herstel, L. J.; Stucchi, R.; Snoek, B. L.; Altelaar, M.; MacGillavry, H. D.; Wierenga, C. J.; Hoogenraad, C. C.
10.1101/2020.04.21.052498 — neuroscience — Posted on 2020-04-21
1617 A Structure-Based Mechanism for DNA Entry into the Cohesin Ring
Higashi, T. L.; Eickhoff, P.; Simoes, J. S.; Locke, J.; Nans, A.; Flynn, H. R.; Snijders, A. P.; Papageorgiou, G.; O'Reilly, N.; Chen, Z. A.; O'Reilly, F. J.; Rappsilber, J.; Costa, A.; Uhlmann, F.
10.1101/2020.04.21.052944 — molecular biology — Posted on 2020-04-21
1618 In vivo high-content screening in zebrafish for developmental nephrotoxicity of approved drugs
Westhoff, J. H.; Steenbergen, P. J.; Thomas, L. S.; Heigwer, J.; Bruckner, T.; Cooper, L.; Toenshoff, B.; Hoffmann, G. F.; Gehrig, J.
10.1101/2020.04.21.052688 — developmental biology — Posted on 2020-04-21
1619 Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
Lee, C.; Cox, R.; Papoulas, O.; Horani, A.; Drew, K.; Devitt, C.; Brody, S. L.; Marcotte, E.; Wallingford, J. B.
10.1101/2020.04.21.052837 — cell biology — Posted on 2020-04-21
1620 Rab14/MACF2/CAMSAP3 Complex Regulates Endosomal Targeting to the Abscission Site During Cytokinesis
Prekeris, R.; Gibieza, P.; Peterman, E.; Hoffman, H. K.; Van Engeleburg, S.; Skeberdis, A.
10.1101/2020.04.21.052449 — cell biology — Posted on 2020-04-21
1624 Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Butler, D. J.; Mozsary, C.; Meydan, C.; Danko, D. C.; Foox, J.; Rosiene, J.; Shaiber, A.; Afshinnekoo, E.; MacKay, M.; Sedlazeck, F. J.; Ivanov, N. A.; Sierra, M. A.; Pohle, D.; Zeitz, M.; Ramlall, V.; Gisladottir, U.; Westover, C. D.; Ryon, K.; Young, B.; Bhattacharya, C.; Ruggiero, P.; Langhorst, B. W.; Tanner, N. A.; Gawrys, J.; Meleshko, D.; Xu, D.; Xiang, J.; Iftner, A.; Bezdan, D.; Sipley, J.; Cong, L.; Craney, A.; Velu, P.; Melnick, A.; Hajirasouliha, I. A.; Iftner, T.; Salvatore, M.; Loda, M.; Westblade, L. F.; Levy, S.; Cushing, M.; Tatonetti, N. P.; Imielinski, M.; Rennert, H.; Mason
10.1101/2020.04.20.048066 — molecular biology — Posted on 2020-04-21
1626 A thymus tumour impairing hibernation
Markussen, F. A. S.; Melum, V. J.; Bothorel, B.; Hazlerigg, D. G.; Simonneaux, V.; Wood, S. H.
10.1101/2020.04.20.009712 — physiology — Posted on 2020-04-21
1627 Cadherin-6 mediates thrombosis in vivo
Bouck, E. G.; de la Fuente, M.; Zunica, E. R.; Li, W.; Mumaw, M. M.; Nieman, M. T.
10.1101/2020.04.20.051045 — pathology — Posted on 2020-04-21
1628 Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain
Moutal, A.; Cai, S.; Yu, J.; Stratton, H. J.; Chefdeville, A.; Gomez, K.; Ran, D.; Madura, C. L.; Boinon, L.; Soto, M.; Zhou, Y.; Shan, Z.; Chew, L. A.; Rodgers, K. A.; Khanna, R.
10.1101/2020.04.20.049106 — neuroscience — Posted on 2020-04-21
1632 Agonist-induced Functional Analysis and Cell Sorting, a novel tool to select and analyze neurons: Fragile X as a proof of concept.
Castagnola, S.; Cazareth, J.; Lebrigand, K.; Jarjat, M.; Delhaye, S.; Magnone, V.; Brau, F.; Bardoni, B.; Maurin, T.
10.1101/2020.04.20.050997 — genomics — Posted on 2020-04-21
1635 Particle-associated and free-living bacterial communities in an oligotrophic sea are affected by different environmental and anthropogenic factors
Roth Rosenberg, D.; Haber, M.; Goldford, J.; Lalzar, M.; Aharonovich, D.; Al-Ashhab, A.; Lehahn, Y.; Krom, M. D.; Segre', D.; Steindler, L.; Sher, D. J.
10.1101/2020.04.20.051391 — ecology — Posted on 2020-04-21
1636 Time-resolved cryoEM using Spotiton
Dandey, V. P.; Budell, W. C.; Wei, H.; Bobe, D.; Maruthi, K.; Kopylov, M.; Eng, E. T.; Kahn, P. A.; Hinshaw, J. E.; Kundu, N.; Nimigean, C. M.; Fan, C.; Sukomon, N.; Darst, S.; Saecker, R.; Chen, J.; Malone, B.; Potter, C. S.; Carragher, B.
10.1101/2020.04.20.050518 — biophysics — Posted on 2020-04-21
1637 Single particle zeta-potential measurements reveal the role of electrostatics in protein condensate stability
Welsh, T. J.; Krainer, G.; Espinosa, J. R.; Joseph, J. A.; Sridhar, A.; Jahnel, M.; Arter, W. E.; Saar, K. L.; Alberti, S.; Collepardo-Guevara, R.; Knowles, T. P. J.
10.1101/2020.04.20.047910 — biophysics — Posted on 2020-04-21
1638 JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications
Kasinath, V.; Beck, C.; Sauer, P.; Poepsel, S.; Kosmatka, J.; Faini, M.; Toso, D.; Aebersold, R.; Nogales, E.
10.1101/2020.04.20.049213 — biophysics — Posted on 2020-04-21
1639 Predicting Longitudinal Disease Severity for Individuals with Parkinson's Disease using Functional MRI and Machine Learning Prognostic Models
Nguyen, K. P.; Raval, V.; Treacher, A.; Mellema, C.; Yu, F.; Pinho, M. C.; Subramaniam, R. M.; Dewey, R. B.; Montillo, A.
10.1101/2020.04.20.050971 — neuroscience — Posted on 2020-04-21
1640 Ligand Sensing Enhances Bacterial Flagellar Motor Output via Stator Recruitment
Naaz, F.; Agrawal, M.; Chakraborty, s.; Tirumkudulu, M. S.; Venkatesh, K. V.
10.1101/2020.04.20.050906 — biophysics — Posted on 2020-04-21
1641 A CRISPR-Cas9-engineered mouse model for GPI anchor deficiency mirrors human phenotype and shows hippocampal synaptic dysfunctions.
Rodriguez de los Santos, M.; Rivalan, M.; David, F. S.; Knaus, A.; Stumpf, A.; Moreno Velasquez, L.; Voigt, A.; Mattei, D.; Long, M.; Vogt, G.; Wittler, L.; Timmermann, B.; Robinson, P. N.; Horn, D.; Mundlos, S.; Kornak, U.; Schmitz, D.; Winter, Y.; Krawitz, P. M.
10.1101/2020.04.20.050591 — neuroscience — Posted on 2020-04-21
1645 Neural correlates of cognitive motor signals in primary somatosensory cortex.
Jaffari, M.; Aflalo, T.; Chivukula, S.; Kellis, S.; Armenta Salas, M.; Norman, S.; Pejsa, K.; Liu, C.; Andersen, R. A.
10.1101/2020.04.20.041269 — neuroscience — Posted on 2020-04-21
1647 Substrate Recognition by γ-Glutamyltransferase: A Molecular Dynamics Simulations Study
Oliva, F.; Flores-Canales, J. C.; Pieraccini, S.; Morelli, C. F.; Sironi, M.; Schiott, B.
10.1101/2020.04.20.050500 — biophysics — Posted on 2020-04-21
1648 Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species
Hendrix, B.; Zheng, W.; Bauer, M. J.; Havecker, E. R.; Mai, J. T.; Hoffer, P. H.; Sanders, R.; Eads, B. D.; Caruano-Yzermans, A.; Taylor, D. N.; Hresko, C.; Oakes, J.; Iandolino, A. B.; Bennett, M. J.; Deikman, J.
10.1101/2020.04.20.052076 — plant biology — Posted on 2020-04-21
1650 Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner
Granger, A. J.; Wang, W.; Robertson, K.; El-Rifai, M.; Zanello, A. F.; Bistrong, K.; Saunders, A.; Chow, B. W.; Nunez, V.; Turrero Garcia, M.; Harwell, C. C.; Gu, C.; Sabatini, B. L.
10.1101/2020.04.20.051276 — neuroscience — Posted on 2020-04-21
1651 Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
Aguilera, A.; Gomez-Gonzalez, B.; Lafuente-Barquero, J.; Martin-Alonso, M. S.
10.1101/2020.04.20.047134 — molecular biology — Posted on 2020-04-21
1652 Consumption of artificially sweetened beverages during pregnancy impacts infant gut microbiota and body mass index
Laforest-Lapointe, I.; Becker, A. B.; Mandhane, P. J.; Turvey, S.; Moraes, T. J.; Sears, M. R.; Subbarao, P.; Sycuro, L. K.; Azad, M. B.; Arrieta, M.-C.
10.1101/2020.04.20.050195 — microbiology — Posted on 2020-04-21
1653 Structured sampling of olfactory input by the fly mushroom body
Zheng, Z.; Li, F.; Fisher, C.; Ali, I. J.; Sharifi, N.; Calle-Schuler, S.; Hsu, J.; Masoodpanah, N.; Kmecova, L.; Kazimiers, T.; Perlman, E.; Nichols, M.; Li, P. H.; Jain, V.; Bock, D. D.
10.1101/2020.04.17.047167 — neuroscience — Posted on 2020-04-21
1654 Antibiotics may influence gut microbiome signaling to the brain in preterm neonates
Russell, J. T.; Ruoss, J. L.; de la Cruz, D.; Li, N.; Bazacliu, C.; Patton, L.; Lobean McKinley, K.; Garrett, T. J.; Polin, R. A.; Triplett, E. W.; Neu, J.
10.1101/2020.04.20.052142 — microbiology — Posted on 2020-04-21
1658 The effects of temporal continuities of grasslands on the diversity and species composition of plants
Taiki, I.; Yaida, Y. A.; Uehara, Y.; Katsuhara, K. R.; Kawai, J.; Takashima, K.; Ushimaru, A.; Kenta, T.
10.1101/2020.04.21.050013 — ecology — Posted on 2020-04-21
1659 Genome architecture and transcription data reveal allelic bias during the cell cycle
Lindsly, S. M.; Jia, W.; Chen, H.; Ronquist, S.; Chen, C.; Wen, X.; Li, S. C.; Wicha, M.; Rehemtulla, A.; Muir, L.; Rajapakse, I.
10.1101/2020.03.15.992164 — genomics — Posted on 2020-04-21
1661 Omics-Based Interaction Framework - a systems model to reveal molecular drivers of synergy
Pantaleon Garcia, J.; Kulkarni, V. V.; Reese, T. C.; Wali, S.; Wase, S. J.; Zhang, J.; Singh, R.; Caetano, M. S.; Moghaddam, S. J.; Johnson, F. M.; Wang, J.; Wang, Y.; Evans, S. E.
10.1101/2020.04.16.041350 — systems biology — Posted on 2020-04-21
1663 A new set of composite, non-redundant electroencephalogram measures of non-rapid eye movement sleep based on the power law scaling of the Fourier spectrum
Bodizs, R.; Szalardy, O.; Horvath, C.; Peter, U. P.; Gombos, F.; Simor, P.; Potari, A.; Zeising, M.; Steiger, A.; Dresler, M.
10.1101/2020.04.09.035113 — neuroscience — Posted on 2020-04-21
1668 The beginning of the end: a chromosomal assembly of the New World malaria mosquito ends with a novel telomere
Compton, A.; Liang, J.; Chen, C.; Lukyanchikova, V.; Qi, Y.; Potters, M.; Settlage, R.; Miller, D.; Deschamps, S.; Mao, C.; Llaca, V.; Sharakhov, I. V.; Tu, Z.
10.1101/2020.04.17.047084 — genomics — Posted on 2020-04-21
1670 Insect herbivory on urban trees: Complementary effects of tree neighbours and predation
Stemmelen, A.; Paquette, A.; Benot, M.-L.; Kadiri, Y.; Jactel, H.; Castagneyrol, B.
10.1101/2020.04.15.042317 — ecology — Posted on 2020-04-21
1671 Characterization of essential eggshell proteins from Aedes aegypti mosquitoes
Simington, C. J.; Oscherwitz, M. E.; Peterson, A. J.; Rascon, A. A.; Massani, B. B.; Miesfeld, R.; ISOE, J.
10.1101/2020.04.06.027706 — developmental biology — Posted on 2020-04-21
1672 Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endodermal gene regulatory network
Mukherjee, S.; Chaturvedi, P.; Rankin, S. A.; Fish, M. B.; Wizla, M.; Paraiso, K. D.; MacDonald, M.; Chen, X.; Weirauch, M. T.; Blitz, I. L.; Cho, K. W. Y.; Zorn, A.
10.1101/2020.02.19.956565 — developmental biology — Posted on 2020-04-21
1677 Simple Behavioral Analysis (SimBA): an open source toolkit for computer classification of complex social behaviors in experimental animals
Nilsson, S. R. O.; Goodwin, N. L.; Choong, J. J.; Hwang, S.; Wright, H. R.; Norville, Z.; Tong, X.; Lin, D.; Bentzley, B. S.; Eshel, N.; McLaughlin, R. J.; Golden, S. A.
10.1101/2020.04.19.049452 — animal behavior and cognition — Posted on 2020-04-21
1678 Neuronal Hyperexcitability is a DLK-dependent Trigger of HSV-1 Reactivation that can be Induced by IL-1
Cuddy, S.; Schinlever, A. R.; Dochnal, S.; Suzich, J.; Kundu, P.; Downs, T. K.; Farah, M.; Desai, B.; Boutell, C.; Cliffe, A. R.
10.1101/2020.04.16.044875 — microbiology — Posted on 2020-04-21
1682 Generation of cardiac valve endocardial like cells from human pluripotent stem cells
sun, y.; Cheng, L.; Geng, Y.; Song, Y.; Wang, Z.; Wang, L.; Xu, W.; Huang, K.; Dong, N.
10.1101/2020.04.20.050161 — developmental biology — Posted on 2020-04-21
1686 Evaluating features of scientific conferences: A call for improvements
Sarabipour, S.; Schwessinger, B.; Mumoki, F. N.; Mwakilili, A. D.; Khan, A.; Debat, H. J.; Saez, P.; Seah, S.; Mestrovic, T.
10.1101/2020.04.02.022079 — scientific communication and education — Posted on 2020-04-21
1687 Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
Pinto-Fernandez, A.; Salio, M.; Partridge, T.; Chen, J.; Vere, G.; Greenwood, H.; Olie, C. S.; Damianou, A.; Scott, H. C.; Pegg, H. J.; Chiarenza, A.; Diaz-Saez, L.; Smith, P.; Gonzalez-Lopez, C.; Patel, B.; Anderton, E.; Jones, N.; Huber, K.; Muschel, R.; Borrow, P.; Cerundolo, V.; Kessler, B. M.
10.1101/2020.03.31.005629 — cancer biology — Posted on 2020-04-21
1691 Vegetation and Microbes Interact to Preserve Organic Matter in Wooded Peatlands
Wang, H.; Tian, J.; Chen, H.; Ho, M.; Vilgalys, R.; Liu, X.; Richardson, C. J.
10.1101/2020.04.11.034108 — ecology — Posted on 2020-04-21
1692 Machine learning predicts immunoglobulin light chain toxicity through somatic mutations
Garofalo, M.; Piccoli, L.; Ravasio, S.; Foglierini, M.; Matkovic, M.; Sgrignani, J.; Prunotto, M.; Michielin, O.; Lanzavecchia, A.; Cavalli, A.; Romeo, M.; Diomede, L.
10.1101/849901 — bioinformatics — Posted on 2020-04-21
1693 Dissociable mechanisms govern when and how strongly reward attributes affect decisions
Maier, S. U.; Raja Beharelle, A.; Polania, R.; Ruff, C. C.; Hare, T. A.
10.1101/434860 — neuroscience — Posted on 2020-04-21
1695 Comprehensive gene expression analysis detects global reduction of proteasome subunits in schizophrenia
Hertzberg, L.; Maggio, N.; Muler, I.; Yitzhaky, A.; Majer, M.; Haroutunian, V.; Katsel, P.; Domany, E.; Weiser, M.
10.1101/853226 — neuroscience — Posted on 2020-04-21
1697 Grapevine pruning time affects natural wound colonization by wood-invading fungi
Martinez-Diz, M. d. P.; Eichmeier, A.; Spetik, M.; Bujanda, R.; Diaz-Fernandez, A.; Diaz-Losada, E.; Gramaje, D.
10.1101/2020.04.20.050955 — microbiology — Posted on 2020-04-21
1704 Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells
Holthaus, D.; Vasou, A.; Bamford, C. G.; Andrejeva, J.; Paulus, C.; Randall, R. E.; McLauchlan, J.; Hughes, D. J.
10.1101/2019.12.12.873919 — immunology — Posted on 2020-04-21
1705 Paralogs and off-target sequences improve phylogenetic resolution in a densely-sampled study of the breadfruit genus (Artocarpus, Moraceae)
Gardner, E. M.; Johnson, M. G.; Pereira, J. T.; Puad, A. S. A.; Arifiani, D.; Sahromi, S.; Wickett, N. J.; Zerega, N. J. C.
10.1101/854232 — evolutionary biology — Posted on 2020-04-21
1706 Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities
Kelly, M. R.; Kostyrko, K.; Han, K.; Mooney, N.; Jeng, E. E.; Abbott, K. L.; Gwinn, D. M.; Sweet-Cordero, E. A.; Bassik, M. C.; Jackson, P. K.
10.1101/2020.04.20.051623 — cancer biology — Posted on 2020-04-21
1708 Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system
Driscoll, J. R.; Wallace, T. L.; Mansourian, K. A.; Martin, W. J.; Margolis, E. B.
10.1101/776484 — neuroscience — Posted on 2020-04-21
1709 Genome-wide association analyses identify variants in IRF4 associated with acute myeloid leukemia and myelodysplastic syndrome susceptibility
Wang, J.; Clay-Gilmour, A.; Karaesmen, E.; Rizvi, A. A.; Zhu, Q.; Yan, L.; Preus, L. M.; Liu, S.; Wang, Y.; Griffiths, E.; Stram, D. O.; Pooler, L.; Sheng, X.; Haiman, C. A.; Van Den Berg, D.; Webb, A.; Brock, G.; Spellman, S.; Pasquini, M.; McCarthy, P.; Allan, J.; Stölzel, F.; Onel, K.; Hahn, T.; Sucheston-Campbell, L.
10.1101/773952 — genomics — Posted on 2020-04-21
1711 Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm lineage diversification during foregut organogenesis
Han, L.; Chaturvedi, P.; Kishimoto, K.; Koike, H.; Nasr, T.; Iwasawa, K.; Giesbrecht, K.; Witcher, P. C.; Eicher, A.; Haines, L.; Lee, Y.; Shannon, J. M.; Morimoto, M.; Wells, J. M.; Takebe, T.; Zorn, A.
10.1101/756825 — developmental biology — Posted on 2020-04-21
1713 Clearing-induced tissue shrinkage: Novel observation of a thickness size effect.
Vulders, R. C. M.; van Hoogenhuizen, R. C.; van der Giessen, E.; van der Zaag, P. J.
10.1101/2020.04.20.051771 — biophysics — Posted on 2020-04-21
1715 PAN: Personalized Annotation-based Networks for the Prediction of Breast Cancer Relapse
Nguyen, T.; Lee, S. C.; Quinn, T. P.; Truong, B.; Li, X.; Tran, T.; Venkatesh, S.; Le, T. D.
10.1101/534628 — bioinformatics — Posted on 2020-04-21
1717 Flow cytometric analysis and purification of airway epithelial cell subsets
Bonser, L. R.; Koh, K. D.; Johansson, K.; Choksi, S. P.; Cheng, D.; Liu, L.; Sun, D. I.; Zlock, L. T.; Eckalbar, W. L.; Finkbeiner, W. E.; Erle, D. J.
10.1101/2020.04.20.051383 — cell biology — Posted on 2020-04-21
1719 Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
Mich, J. K.; Graybuck, L. T.; Hess, E. E.; Mahoney, J. T.; Kojimo, Y.; Ding, Y.; Somasundaram, S.; Miller, J. A.; Weed, N.; Omstead, V.; Bishaw, Y.; Shapovalova, N. V.; Martinez, R. A.; Fong, O.; Yao, S.; Mortrud, M.; Chong, P.; Loftus, L.; Bertagnolli, D.; Goldy, J.; Casper, T.; Dee, N.; Opitz-Araya, X.; Cetin, A.; Smith, K. A.; Gwinn, R. P.; Cobbs, C.; Ko, A. L.; Ojemann, J. G.; Keene, C. D.; Silbergeld, D. L.; Sunkin, S. M.; Gradinaru, V.; Horwitz, G. D.; Zeng, H.; Tasic, B.; Lein, E. S.; Ting, J. T.; Levi, B. P.
10.1101/555318 — neuroscience — Posted on 2020-04-21
1720 Cellular correlates of cortical thinning throughout the lifespan
Vidal-Pineiro, D.; Parker, N.; Shin, J.; French, L.; Grydeland, H.; Jackowski, A. P.; Mowinckel, A. M.; Patel, Y.; Pausova, Z.; Salum, G.; Sorensen, O.; Walhovd, K. B.; Paus, T.; Fjell, A. M.; the AIBL,
10.1101/585786 — neuroscience — Posted on 2020-04-21
1721 Inflammation and epigenetic age in Alzheimer's disease: do sex and APOE matter?
Duarte-Guterman, P.; Inkster, A. M.; Albert, A. Y.; Barha, C. K.; Robinson, W.; Galea, L.
10.1101/741777 — neuroscience — Posted on 2020-04-21
1722 Rapid cortical plasticity induced by active associative learning of novel words in human adults
Razorenova, A. M.; Chernyshev, B. V.; Nikolaeva, A. Y.; Butorina, A. V.; Prokofyev, A. O.; Tyulenev, N. B.; Stroganova, T. A.
10.1101/716712 — neuroscience — Posted on 2020-04-21
1724 Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling
Graybuck, L. T.; Daigle, T.; Sedeno-Cortes, A.; Walker, M.; Kalmbach, B.; Lenz, G. H.; Nguyen, T. N.; Garren, E.; Kim, T. K.; Sieverts, L.; Bendrick, J. L.; Zhou, T.; Mortrud, M.; Yao, S.; Cetin, A. H.; Larsen, R.; Esposito, L.; Gore, B.; Szelenyi, E. R.; Morin, E.; Mich, J. K.; Dee, N.; Goldy, J.; Smith, K. A.; Yao, Z.; Gradinaru, V.; Sunkin, S. M.; Lein, E.; Levi, B. P.; Ting, J.; Zeng, H.; Tasic, B.
10.1101/525014 — neuroscience — Posted on 2020-04-21
1725 Identifying Novel Drug and Vaccine Molecules of Vibrio parahaemolyticus by Subtractive Proteomics and Vaccinomics Approach
Hasan, M.; Azim, K. F.; Imran, A. S.; Chowdhury, I. M.; Urme, S. R. A.; Parvez, M. S. A.; Khan, M. T.; Uddin, M. B.; Ahmed, S. S. U.
10.1101/2020.04.17.045849 — microbiology — Posted on 2020-04-21
1726 Cross-scale dynamics and the evolutionary emergence of infectious diseases
Schreiber, S. J.; Ke, R.; Loverdo, C.; Park, M.; Ahsan, P.; Lloyd-Smith, J. O.
10.1101/066688 — epidemiology — Posted on 2020-04-21
1728 The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity
Demy, D. L.; Carrere, M.; Noche, R.; Tauzin, M.; Le Bris, M.; Baek, C.; Yousfi, M.; Leshchiner, I.; Goessling, W.; Herbomel, P.
10.1101/2020.04.20.051664 — developmental biology — Posted on 2020-04-21
1730 Structure-guided point mutations on FusionRed produce a brighter red fluorescent protein
Mukherjee, S.; Hung, S.; Douglas, N.; Manna, P.; Thomas, C. D.; Ekrem, A.; Palmer, A. E.; Jimenez, R.
10.1101/2020.04.20.051763 — biophysics — Posted on 2020-04-21
1733 Affinity proteomic dissection of the human nuclear cap-binding-complex interactome
Dou, Y.; Kalmykova, S.; Pashkova, M.; Oghbaie, M.; Jiang, H.; Molloy, K. R.; Chait, B. T.; Rout, M. P.; Fenyo, D.; Jensen, T. H.; Altukhov, I.; LaCava, J.
10.1101/2020.04.20.048470 — biochemistry — Posted on 2020-04-21
1737 Adherens junction serves to generate cryptic lamellipodia required for collective migration of epithelial cells
Ozawa, M.; Hiver, S.; Yamamoto, T.; Shibata, T.; Upadhyayula, S.; Mimori-Kiyosue, Y.; Takeichi, M.
10.1101/2020.04.20.052118 — cell biology — Posted on 2020-04-21
1742 Digestive parameters during gestation of Holstein heifers
Pereira, J. M. V.; Marcondes, M. I.; Filho, S. d. C. V.; Caton, J.; Sguizzato, A. L. L.; Silva, A. L.; Travassos da Silva, J.; Lima Moraes, V. C.; Gomes, L. F.; Rotta, P.
10.1101/2020.04.20.050773 — physiology — Posted on 2020-04-20
1744 Interactions between fungal hyaluronic acid and host CD44 promotes internalization by recruiting host autophagy proteins to forming phagosomes
Ding, S.; Pandey, A.; Feng, X.; Yang, J.; da Costa, L. F.; Mouneimne, R. B.; Rice-Ficht, A.; Bell, S. L.; Watson, R. O.; Patrick, K. L.; Qin, Q.-M.; Ficht, T. A.; de Figueiredo, P.
10.1101/2020.04.20.047621 — microbiology — Posted on 2020-04-20
1746 Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein for neutralization assays
Crawford, K. H. D.; Eguia, R.; Dingens, A. S.; Loes, A. N.; Malone, K. D.; Wolf, C. R.; Chu, H. Y.; Tortorici, M. A.; Veesler, D.; Murphy, M.; Pettie, D.; King, N. P.; Balazs, A. B.; Bloom, J. D.
10.1101/2020.04.20.051219 — microbiology — Posted on 2020-04-20
1747 Platelets exploit fibrillar adhesions to assemble fibronectin matrix revealing new force-regulated thrombus remodeling mechanisms
Lickert, S.; Selcuk, K.; Kenny, M.; Mehl, J.; Fruh, S.; Burkhardt, M. A.; Studt, J.-D.; Schoen, I.; Vogel, V.
10.1101/2020.04.20.050708 — cell biology — Posted on 2020-04-20
1748 Functional Interrogation of HOXA9 Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screen
zhang, h.; zhang, y.; wright, s.; Hyle, J.; Zhao, L.; An, J.; Zhou, X.; zhao, x.; shao, y.; Lee, H.-M.; chen, t.; zhou, y.; Xu, B.; Lu, R.; Li, C.
10.1101/2020.04.20.050583 — cancer biology — Posted on 2020-04-20
1749 Erythropoietin directly affects single hematopoietic stem cell differentiation after transplantation
Eisele, A. S.; Cosgrove, J.; Magniez, A.; Tubeuf, E.; Tenreira Bento, S.; Cayrac, F.; Tak, T.; Lyne, A.-M.; Urbanus, J.; Perie, L.
10.1101/2020.04.20.050146 — immunology — Posted on 2020-04-20
1751 Nsr1, a nitrogen source-regulated microprotein, confers an alternative mechanism of G1/S transcriptional activation in budding yeast
Tollis, S.; Singh, J.; Thattikota, Y.; Tang, X.; Moore, S.; Blake, D.; Coulombe-Huntington, J.; Bonneil, E.; Royer, C. A.; Thibault, P.; Tyers, M.
10.1101/2020.04.20.033787 — cell biology — Posted on 2020-04-20
1752 An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays
Suarez-Arnedo, A.; Torres Figueroa, F.; Clavijo, C.; Arbelaez, P.; Cruz, J. C.; Munoz, C.
10.1101/2020.04.20.050831 — bioengineering — Posted on 2020-04-20
1755 Abortion and various associated risk factors in dairy cow and sheep in Ili, China
Deng, X.; Zhang, H.; Shao, Z.; Zhao, X.; Yang, Q.; Song, S.; Wang, Z.; Wang, Y.; Wang, Y.; Sheng, J.; chen, c.
10.1101/2020.04.20.050872 — zoology — Posted on 2020-04-20
1756 Antibiotic-resistant Salmonella species and Escherichia coli in broiler chickens from farms, abattoirs and open markets in selected districts of Zambia
Phiri, N.; Mainda, G.; Mukuma, M.; Sinyangwe, N. N.; Banda, L. J.; Kwenda, G.; Muonga, E. M.; Flavien, B. N.; Mwansa, M.; Yamba, k.; Munyeme, M.; Muma, J. B.
10.1101/2020.04.20.050914 — scientific communication and education — Posted on 2020-04-20
1758 An immunohistochemical prostate cell identification key indicates that aging shifts procollagen 1A1 production from myofibroblasts to fibroblasts in dogs prone to prostate-related urinary dysfunction
Ruetten, H.; Cole, C.; Wehber, M.; Wegner, K. A.; Girardi, N. M.; Peterson, N. T.; Scharpf, B. R.; Romero, M. F.; Wood, M. W.; Colopy, S. A.; Bjorling, D. E.; Vezina, C. M.
10.1101/2020.04.20.050856 — pathology — Posted on 2020-04-20
1761 Phylodynamics of SARS-CoV-2 transmission in Spain
Diez Fuertes, F.; Iglesias Caballero, M.; Monzon, S.; Jimenez, P.; Varona, S.; Cuesta, I.; Zaballos, A.; Thomson, M. M.; Jimenez, M.; Garcia Perez, J.; Pozo, F.; Perez Olmeda, M.; Alcami, J.; Casas, I.
10.1101/2020.04.20.050039 — microbiology — Posted on 2020-04-20
1763 Limited SARS-CoV-2 diversity within hosts and following passage in cell culture
Moreno, G. K.; Braun, K. M.; Halfmann, P. J.; Prall, T. M.; Riemersma, K. K.; Haj, A. K.; Lalli, J.; Florek, K. R.; Friedrich, T. C.; Kawaoka, Y.; O'Connor, D. H.
10.1101/2020.04.20.051011 — microbiology — Posted on 2020-04-20
1764 Pseudomonas aeruginosa biofilms display carbohydrate ligands for CD206 and CD209 that interfere with their receptor function
Singh, S.; Almuhanna, Y.; Alshahrani, M.; Lowman, D.; Rice, P. J.; Gell, C.; Ma, Z.; Graves, B. M.; Jackson, D.; Lee, K.; Kelkar, R.; Koranteng, J.; Mitchell, D.; da Silva, A.; Hussain, F.; Yilmaz, G.; Mastrotto, F.; Irie, Y.; Williams, P.; Williams, D. L.; Camara, M.; Martinez-Pomares, L.
10.1101/2020.04.20.051292 — microbiology — Posted on 2020-04-20
1766 Schistosoma mansoni infection induces long-lived sex-specific metabolic reprogramming of the myeloid lineage
Cortes-Selva, D.; Gibbs, L.; Maschek, J. A.; Van Ry, T.; Rajwa, B.; Cox, J. E.; Amiel, E.; Fairfax, K.
10.1101/2020.04.20.050898 — immunology — Posted on 2020-04-20
1770 Genotypic and phenotypic characterization of Streptococcus mutans isolated from dental caries
Hossain, M. S.; Hossain, M. S.; Alam, S.; Nibir, Y. M.; Tusty, T. A.; Bulbul, S. M.; Shahidul Islam, S.
10.1101/2020.04.20.050781 — microbiology — Posted on 2020-04-20
1772 Blocking antibodies against SARS-CoV-2 RBD isolated from a phage display antibody library using a competitive biopanning strategy
Zeng, X.; Li, L.; Lin, J.; Li, X.; Liu, B.; Kong, Y.; Zeng, S.; Du, J.; Xiao, H.; Zhang, T.; Zhang, S.; Liu, J.
10.1101/2020.04.19.049643 — microbiology — Posted on 2020-04-20
1773 SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
Ogando, N.; Dalebout, T.; Zevenhoven-Dobbe, J. C.; Limpens, R. W. A. L.; van der Meer, Y.; Caly, L.; Druce, J.; de Vries, J.; Kikkert, M.; Barcena, M.; Sidorov, I.; Snijder, E. J.
10.1101/2020.04.20.049924 — microbiology — Posted on 2020-04-20
1775 Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Muus, C.; Luecken, M. D.; Eraslan, G.; Waghray, A.; Heimberg, G.; Sikkema, L.; Kobayashi, Y.; Vaishnav, E. D.; Subramanian, A.; Smillie, C.; Jagadeesh, K.; Duong, E. T.; Fiskin, E.; Torlai Triglia, E.; Ansari, M.; Cai, P.; Lin, B.; Buchanan, J.; Chen, S.; Shu, J.; Haber, A. L.; Chung, H.; Montoro, D. T.; Adams, T.; Aliee, H.; Allon, S. J.; Andrusivova, Z.; Angelidis, I.; Ashenberg, O.; Bassler, K.; Becavin, C.; Benhar, I.; Bergenstrahle, J.; Bergenstrahle, L.; Bolt, L.; Braun, E.; Bui, L. T.; Chaffin, M.; Chichelnitskiy, E.; Chiou, J.; Conlon, T. M.; Cuoco, M. S.; Deprez, M.; Fischer, D. S.; G
10.1101/2020.04.19.049254 — bioinformatics — Posted on 2020-04-20
1776 ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway
Ito, S. S.; Nakagawa, Y.; Matsubayashi, M.; Sakaguchi, Y. M.; Kobashigawa, S.; Matsui, T. K.; Nanaura, H.; Nakanishi, M.; Kitayoshi, F.; Kikuchi, S.; Kajihara, A.; Tamaki, S.; Sugie, K.; Kashino, G.; Takahashi, A.; Hasegawa, M.; Mori, E.; Kirita, T.
10.1101/2020.04.20.051318 — cancer biology — Posted on 2020-04-20
1782 Time-resolved transcriptome of barley anthers and meiocytes reveals robust and largely stable gene expression changes at meiosis entry
Barakate, A.; Orr, J.; Schreiber, M.; Colas, I.; Lewandowska, D.; McCallum, N.; Macaulay, M.; Morris, J.; Arrieta, M.; Hedley, P. E.; Ramsay, L.; Waugh, R.
10.1101/2020.04.20.051425 — developmental biology — Posted on 2020-04-20
1783 Connectivity establishes spatial readout of visual looming in a glomerulus lacking retinotopy
Morimoto, M. M.; Nern, A.; Zhao, A.; Rogers, E. M.; Wong, A. M.; Isaacson, M. D.; Bock, D. D.; Rubin, G. M.; Reiser, M. B.
10.1101/2020.04.19.036947 — neuroscience — Posted on 2020-04-20
1784 Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Butler, D. J.; Mozsary, C.; Meydan, C.; Danko, D. C.; Foox, J.; Rosiene, J.; Shaiber, A.; Afshinnekoo, E.; MacKay, M.; Sedlazeck, F. J.; Ivanov, N. A.; Sierra, M. A.; Pohle, D.; Zeitz, M.; Gisladottir, U.; Westover, C. D.; Ryon, K.; Young, B.; Bhattacharya, C.; Ruggiero, P.; Langhorst, B. W.; Tanner, N. A.; Gawrys, J.; Meleshko, D.; Xu, D.; Xiang, J.; Iftner, A.; Bezdan, D.; Sipley, J.; Cong, L.; Craney, A.; Velu, P.; Melnick, A.; Hajirasouliha, I. A.; Iftner, T.; Salvatore, M.; Loda, M.; Westblade, L. F.; Levy, S.; Cushing, M.; Tatonetti, N. P.; Imielinski, M.; Rennert, H.; Mason, C.
10.1101/2020.04.20.048066 — molecular biology — Posted on 2020-04-20
1785 Impact of removing a concrete gas platform on benthic communities in the North Sea
Coolen, J. W. P.; Bittner, O.; Driessen, F. M. F.; van Dongen, U.; Siahaya, M. S.; de Groot, W.; van der Weide, B.
10.1101/2020.04.16.044263 — ecology — Posted on 2020-04-20
1786 Ecosystem Entanglement and the Propagation of Nutrient-Driven Instability
McCann, K.; MacDougall, A.; Bieg, C.; Fryxell, J.; Fussmann, G.; Cazelles, K.; Cristescu, M.; Gellner, G.; LaPointe, B.; Gonzalez, A.
10.1101/2020.04.20.050302 — ecology — Posted on 2020-04-20
1787 The nose is mightier than the tooth: larger male proboscis monkeys have smaller canines
Matsuda, I.; Stark, D. J.; Saldivar, D. A. R.; Tuuga, A.; Nathan, S. K. S. S.; Goossens, B.; van Schaik, C. P.; Koda, H.
10.1101/848515 — evolutionary biology — Posted on 2020-04-20
1788 The latitudinal diversity gradient in brush-footed butterflies (Nymphalidae): conserved ancestral tropical niche but different continental histories.
Chazot, N.; Condamine, F.; Dudas, G.; Pena, C.; Matos-Maravi, P.; Freitas, A. V.; Willmott, K. R.; Elias, M.; Warren, A.; Aduse-Poku, K.; Lohman, D. J.; Penz, C. M.; DeVries, P.; Kodandaramaiah, U.; Fric, Z. F.; Nylin, S.; Muller, C.; Wheat, C.; Kawahara, A. Y.; Silva-Brandao, K. L.; Lamas, G.; Zubek, A.; Ortiz-Acevedo, E.; Vila, R.; Vane-Wright, R. I.; Mullen, S. P.; Jiggins, C. D.; Slamova, I.; Wahlberg, N.
10.1101/2020.04.16.045575 — ecology — Posted on 2020-04-20
1789 A scientometric overview of CORD-19
Colavizza, G.; Costas, R.; Traag, V. A.; van Eck, N. J.; van Leeuwen, T.; Waltman, L.
10.1101/2020.04.20.046144 — scientific communication and education — Posted on 2020-04-20
1793 Reprogramming acetogenic bacteria with CRISPR-targeted base editing via deamination
Xia, P.-F.; Casini, I.; Schulz, S.; Klask, C.-M.; Angenent, L. T.; Molitor, B.
10.1101/2020.04.20.047845 — synthetic biology — Posted on 2020-04-20
1795 Multiscale three-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
Li, G.; Fox, S. E.; Summa, B.; Hu, B.; Wenk, C.; Akmatbekov, A.; Harbert, J. L.; Vander Heide, R. S.; Brown, J. Q.
10.1101/2020.04.11.037473 — pathology — Posted on 2020-04-20
1797 Chimpanzee Brain Morphometry Utilizing Standardized MRI Preprocessing and Macroanatomical Annotations
Vickery, S.; Hopkins, W. D.; Sherwood, C. C.; Schapiro, S. J.; Latzman, R. D.; Caspers, S.; Gaser, C.; Eickhoff, S. B.; Dahnke, R.; Hoffstaedter, F.
10.1101/2020.04.20.046680 — neuroscience — Posted on 2020-04-20
1799 Evaluation of heating and chemical protocols for inactivating SARS-CoV-2
Pastorino, B.; Touret, F.; Gilles, M.; de Lamballerie, X.; Charrel, R. N.
10.1101/2020.04.11.036855 — microbiology — Posted on 2020-04-20
1804 The global population of SARS-CoV-2 is composed of six major subtypes
Morais Junior, I. J.; Costa Polveiro, R.; Souza, G. M.; Bortolin, D. I.; Sassaki, F. T.; Lima, A. T. M.
10.1101/2020.04.14.040782 — bioinformatics — Posted on 2020-04-20
1807 Global analysis of protein stability by temperature and chemical denaturation
Hamborg, L.; Horsted, E. W.; Johansson, K. E.; Willemoës, M.; Lindorff-Larsen, K.; Teilum, K.
10.1101/2020.04.20.049429 — biophysics — Posted on 2020-04-20
1808 One-shot analysis of translated mammalian lncRNAs with AHARIBO
Minati, L.; Firrito, C.; Del Piano, A.; Peretti, A.; Sidoli, S.; Peroni, D.; Belli, R.; Gandolfi, F.; Romanel, A.; Bernabo, P.; Zasso, J.; Quattrone, A.; Guella, G.; Lauria, F.; Viero, G.; Clamer, M.
10.1101/2020.04.20.050062 — cell biology — Posted on 2020-04-20
1810 Generation of cardiac valve endocardial like cells from human pluripotent stem cells
sun, y.; Cheng, L.; Geng, Y.; Song, Y.; Wang, Z.; Wang, L.; Xu, W.; Huang, K.; Dong, N.
10.1101/2020.04.20.050161 — developmental biology — Posted on 2020-04-20
1812 Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)
Watanabe, K.; Morishita, K.; Zhou, X.; Shiizaki, S.; Uchiyama, Y.; Koike, M.; Naguro, I.; Ichijo, H.
10.1101/2020.04.20.049759 — cell biology — Posted on 2020-04-20
1814 Hypomethylated poplars show higher tolerance to water deficit and highlight a dual role for DNA methylation in shoot meristem: regulation of stress response and genome integrity
Sow, M. D.; Le Gac, A.-L.; Fichot, R.; Lanciano, S.; Delaunay, A.; Le Jan, I.; Lesage-Descauses, M.-C.; Citerne, S.; Caius, J.; Brunaud, V.; Soubigou-Taconnat, L.; Cochard, H.; Segura, V.; Chaparro, C.; Grunau, C.; Daviaud, C.; Tost, J.; Brignolas, F.; Strauss, S. H.; Mirouze, M.; Maury, S.
10.1101/2020.04.16.045328 — plant biology — Posted on 2020-04-20
1817 A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones, E.; Jardine, J.; Kallinos, A.; Pinto-Fernandez, A.; Guenther, F.; Giurrandino, M.; Barone, F. G.; McCarron, K.; Burke, C. J.; Murad, A.; Martinez, A.; Marcassa, E.; Gersch, M.; Buckmelter, A.; Kayser-Bricker, K.; Lamoliatte, F.; Gajbhiye, A.; Davis, S.; Scott, H. C.; Murphy, E.; England, K.; Mortiboys, H.; Komander, D.; Trost, M.; Kessler, B. M.; Ioannidis, S.; Ahlijanian, M.; Urbe, S.; Clague, M. J.
10.1101/2020.04.16.044206 — cell biology — Posted on 2020-04-20
1818 A calcium-based plasticity model predicts long-term potentiation and depression in the neocortex
Chindemi, G.; Abdellah, M.; Amsalem, O.; Benavides-Piccione, R.; Delattre, V.; Doron, M.; Ecker, A.; King, J. G.; Kumbhar, P.; Monney, C. C.; Perin, R.; Rössert, C.; Van Geit, W.; DeFelipe, J.; Graupner, M.; Segev, I.; Markram, H.; Müller, E. B.
10.1101/2020.04.19.043117 — neuroscience — Posted on 2020-04-20
1823 GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals
Bhandari, P.; Vandael, D.; Fernandez-Fernandez, D.; Fritzius, T.; Kleindienst, D.; Montanaro, J.; Gassmann, M.; Kulik, A.; Jonas, P.; Bettler, B.; Shigemoto, R.; Koppensteiner, P.
10.1101/2020.04.16.045112 — neuroscience — Posted on 2020-04-20
1824 Deregulation of the histone H3K9 dimethylation landscape suppresses Wnt signaling in embryonal rhabdomyosarcoma
Taneja, R.; Pal, A.; Leung, J. Y.; Ang, G. C. K.; Rao, V. K.; Pignata, L.; Lim, H. J.; Hebrard, M.; Chang, K. T.; Lee, V. K.; Guccione, E.
10.1101/2020.04.20.050120 — molecular biology — Posted on 2020-04-20
1825 The ΔF508 CFTR defect: molecular mechanism of suppressor mutation V510D and the contribution of transmembrane helix unraveling
Simon, K. S.; Nagarajan, K.; Mechin, I.; Duffy, C.; Manavalan, P.; Altmann, S.; Majewski, A.; Foley, J.; Kaczmarek, J. S.; Bercury, S.; Maderia, M.; Hilbert, B. J.; Batchelor, J. D.; Ziegler, R.; Bajko, J.; Kothe, M.; Scheule, R. K.; Nair, A.; Hurlbut, G. D.
10.1101/2020.04.19.049338 — biochemistry — Posted on 2020-04-20
1826 Natural variation in autumn FLC levels, rather than epigenetic silencing, aligns vernalization to different climates
Hepworth, J.; Antoniou-Kourounioti, R. L.; Berggren, K.; Selga, C.; Tudor, E.; Yates, B.; Cox, D.; Collier Harris, B. R.; Irwin, J.; Howard, M.; Säll, T.; Holm, S.; Dean, C.
10.1101/2020.04.19.049148 — molecular biology — Posted on 2020-04-20
1828 Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Butler, D. J.; Mozsary, C.; Meydan, C.; Danko, D. C.; Foox, J.; Rosiene, J.; Shaiber, A.; Afshinnekoo, E.; MacKay, M.; Sedlazeck, F. J.; Ivanov, N. A.; Sierra, M. A.; Pohle, D.; Zeitz, M.; Gisladottir, U.; Westover, C. D.; Ryon, K.; Young, B.; Bhattacharya, C.; Ruggiero, P.; Langhorst, B. W.; Tanner, N. A.; Gawrys, J.; Meleshko, D.; Xu, D.; Xiang, J.; Iftner, A.; Bezdan, D.; Sipley, J.; Cong, L.; Craney, A.; Velu, P.; Melnick, A.; Hajirasouliha, I. A.; Iftner, T.; Salvatore, M.; Loda, M.; Westblade, L. F.; Levy, S.; Cushing, M.; Tatonetti, N. P.; Imielinski, M.; Rennert, H.; Mason, C.
10.1101/2020.04.20.048066 — molecular biology — Posted on 2020-04-20
1829 The accumulation of colibactin intermediates does not affect the growth and morphology of pks+Escherichia coli
Morales-Lozada, Y.; Gomez-Moreno, R.; Baez-Bravo, G.; Robledo, I. E.; Suazo-Davila, D.; Cabrera, C. R.; Baerga-Ortiz, A.
10.1101/2020.04.17.047712 — microbiology — Posted on 2020-04-20
1834 The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells
Zhang, J.; Yu, X.; Su, Z.; He, S.; Zhou, Y.; Dai, H.; Hao, X.; Zeng, T.; Wang, W.; Chen, L.
10.1101/2020.04.20.050187 — evolutionary biology — Posted on 2020-04-20
1835 Achromatic body markings as a widespread visual mechanism across group living animals
Negro, J. J.; Dona, J.; Blazquez, C.; Rodriguez, A.; Herbert-Read, J.; Brooke, M. L.
10.1101/2020.04.20.050245 — evolutionary biology — Posted on 2020-04-20
1838 Cell-intrinsic differences between human airway epithelial cells from children and adults
Maughan, E. F.; Nigro, E.; Pennycuick, A.; Gowers, K. H. C.; Denais, C.; Gomez-Lopez, S.; Lazarus, K. A.; Butler, C. R.; Lee, D. D. H.; Orr, J. C.; Teixeira, V. H.; Hartley, B. E.; Hewitt, R. J.; Al Yaghchi, C.; Sandhu, G. S.; Birchall, M. A.; O'Callaghan, C.; Smith, C. M.; De Coppi, P.; Hynds, R. E.; Janes, S. M.
10.1101/2020.04.20.027144 — cell biology — Posted on 2020-04-20
1839 Desert Hedgehog-driven endothelium integrity is enhanced by Gas1 but negatively regulated by Cdon
Chapouly, C.; Hollier, P.-L.; Guimbal, S.; Cornuault, L.; Gadeau, A.-P.; Renault, M.-A.
10.1101/2020.04.20.050542 — cell biology — Posted on 2020-04-20
1840 Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion
Hu, H. T.; Sasakura, N.; Matsubara, D.; Furusawa, N.; Mukai, M.; Kitamura, N.; Obayashi, T.; Nishimura, T.; Oono-Yakura, K.; Funato, Y.; Okamura, Y.; Tarao, K.; Nakano, Y.; Murakami, Y.; Kinoshita, K.; Takahashi, C.; Miki, H.; Gonda, K.; Scita, G.; Hanawa-Suetsugu, K.; Suetsugu, S.
10.1101/2020.04.20.050492 — cell biology — Posted on 2020-04-20
1841 G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
Pribluda, A.; Daemen, A.; Lima, A. N.; Wang, X.; Hafner, M.; Poon, C.; Modrusan, Z.; Katakam, A. K.; Foreman, O.; Eastham, J.; Hung, J.; Haley, B.; Garcia, J. T.; Jackson, E. L.; Junttila, M. R.
10.1101/2020.04.20.050328 — cancer biology — Posted on 2020-04-20
1842 Oncogenes hijack a constitutively active TP53 promoter in osteosarcoma
Saba, K. H.; Cornmark, L.; Kovac, M.; Magnusson, L.; Nilsson, J.; van den Bos, H. H.; Spierings, D. C. J.; Bidgoli, M.; Jonson, T.; Sumathi, V. P.; Brosjo, O.; Staaf, J.; Foijer, F.; Styring, E.; Nathrath, M.; Baumhoer, D.; Nord, K. H.
10.1101/2020.04.20.050252 — cancer biology — Posted on 2020-04-20
1843 Defective membrane repair machinery impairs survival of invasive cancer cells
Bouvet, F.; Ros, M.; Bonedeau, E.; Croissant, C.; Frelin, L.; Saltel, F.; Moreau, V.; Bouter, A.
10.1101/2020.04.20.050211 — cancer biology — Posted on 2020-04-20
1844 ZBTB18 interacts with CTBP2 and represses SREBP genes to inhibit fatty acid synthesis in glioblastoma
Ferrarese, R.; Izzo, A.; Andrieux, G.; Lagies, S.; Masilamani, A. P.; Schulzki, R.; Yuan, S.; Kling, E.; Ribecco, V.; Wasilenko, A.; Heiland, H. D.; Prinz, M.; Kammerer, B.; Börries, M.; Carro, M. S.
10.1101/2020.04.17.046268 — cancer biology — Posted on 2020-04-20
1845 Structural model of the proline-rich domain of huntingtin exon-1 fibrils
Falk, A. S.; Bravo-Arredondo, J. M.; Varkey, J.; Pacheco, S.; Ralf, L.; Siemer, A. B.
10.1101/2020.04.17.046714 — biophysics — Posted on 2020-04-20
1846 The crystal structure of nsp10-nsp16 heterodimer from SARS CoV-2in complex with S-adenosylmethionine
Rosas Lemus, M.; Minasov, G.; Shuvalova, L.; Inniss, N. L.; Kiryukhina, O.; Wiersum, G.; Kim, Y.; Jedrzejczak, R.; Enders, M.; Jaroszewski, L.; Godzik, A.; Joachimiak, A.; Satchell, K. J.
10.1101/2020.04.17.047498 — biochemistry — Posted on 2020-04-20
1852 Thermal Control of T-cell Immunotherapy
Abedi, M. H.; Lee, J.; Piraner, D. I.; Shapiro, M. G.
10.1101/2020.04.16.045146 — bioengineering — Posted on 2020-04-20
1856 OTX2 non-cell autonomous activity regulates inner retinal function
Torero Ibad, R.; Mazhar, B.; Vincent, C.; Bernard, C.; Degardin, J.; Simonutti, M.; Lamonerie, T.; Di Nardo, A.; Prochiantz, A. L.; Moya, K. L.
10.1101/2020.02.12.945584 — neuroscience — Posted on 2020-04-20
1857 Broad and differential animal ACE2 receptor usage by SARS-CoV-2
Zhao, X.; Chen, D.; Szabla, R.; Zheng, M.; Li, G.; Du, P.; Zheng, S.; Li, X.; Song, C.; Li, R.; Guo, J.-T.; Junop, M.; Zeng, H.; Lin, H.
10.1101/2020.04.19.048710 — microbiology — Posted on 2020-04-20
1858 Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspasemediateddeath
Fisch, D.; Clough, B.; Domart, M.-C.; Encheva, V.; Bando, H.; Snijders, A. P.; Collinson, L. M.; Yamamoto, M.; Shenoy, A.; Frickel, E.-M.
10.1101/792804 — microbiology — Posted on 2020-04-20
1859 Spectral graph theory efficiently characterises ventilation heterogeneity in lung airway networks.
Whitfield, C. A.; Latimer, P.; Horsley, A.; Wild, J. M.; Collier, G. J.; Jensen, O. E.
10.1101/2020.04.15.042416 — biophysics — Posted on 2020-04-20
1860 The Structural Basis of the Genetic Code: Amino Acid Recognition by Aminoacyl-tRNA Synthetases
Kaiser, F.; Krautwurst, S.; Salentin, S.; Haupt, V. J.; Leberecht, C.; Bittrich, S.; Labudde, D.; Schroeder, M.
10.1101/606459 — bioinformatics — Posted on 2020-04-20
1862 Efficient assessment of nocturnal flying insect communities by combining automatic light traps and DNA metabarcoding
Mata, V. A.; Ferreira, S.; Campos, R. M.; da Silva, L. P.; Verissimo, J.; Corley, M. F. V.; Beja, P.
10.1101/2020.04.19.048918 — molecular biology — Posted on 2020-04-20
1867 Simple Behavioral Analysis (SimBA): an open source toolkit for computer classification of complex social behaviors in experimental animals
Nilsson, S. R. O.; Goodwin, N. L.; Choong, J. J.; Hwang, S.; Wright, H. R.; Norville, Z.; Tong, X.; Lin, D.; Bentzley, B. S.; Eshel, N.; McLaughlin, R. J.; Golden, S. A.
10.1101/2020.04.19.049452 — animal behavior and cognition — Posted on 2020-04-20
1868 Anthropogenic food enhancement alters the timing of maturational landmarks among wild savanna monkeys (Chlorocebus pygerythrus)
Schmitt, C. A.; Rich, A. M.; Parke, S.-A. R.; Blaszczyk, M. B.; Cramer, J. D.; Freimer, N. B.; Grobler, J. P.; Turner, T. R.
10.1101/2020.04.18.048314 — zoology — Posted on 2020-04-20
1871 Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration
Tejwani, L.; Kokubu, H.; Lee, P. J.; Xiang, Y.; Luttik, K.; Soriano, A.; Yoon, J.; Park, J.; Ro, H.; Ju, H.; Liao, C.; Tieze, S.; Rigo, F.; Jafar-Nejad, P.; Lim, J.
10.1101/2020.04.19.049395 — neuroscience — Posted on 2020-04-20
1873 A novel framework for characterizing genomic haplotype diversity in the human immunoglobulin heavy chain locus
Rodriguez, O. L.; Gibson, W. S.; Parks, T. T.; Emery, M.; Powell, J.; Strahl, M.; Deikus, G.; Auckland, K.; Eichler, E. E.; Marasco, W. A.; Sebra, R.; Sharp, A. J.; Smith, M. L.; Bashir, A.; Watson, C. T.
10.1101/2020.04.19.049270 — genomics — Posted on 2020-04-20
1880 Parallel RNA and DNA analysis after Deep-sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain
Huang, A. Y.; Li, P.; Rodin, R. E.; Kim, S. N.; Dou, Y.; Kenny, C. J.; Akula, S. K.; Hodge, R. D.; Bakken, T. E.; Miller, J. A.; Lein, E. S.; Park, P. J.; Lee, E. A.; Walsh, C. A.
10.1101/2020.04.19.046904 — neuroscience — Posted on 2020-04-20
1884 TRIP6 is required for tension at adherens junctions
Venkatramanan, S.; Ibar Valenzuela, M. C.; Irvine, K.
10.1101/2020.04.19.049569 — cell biology — Posted on 2020-04-20
1885 ProtTox: Toxin identification from Protein Sequences
Datta, D.; Muthiah, S.; Butler, P.; Islam, M. R.; Warren, A.; Ramakrishnan, N.
10.1101/2020.04.18.048439 — bioinformatics — Posted on 2020-04-20
1888 Production of a tributyltin-binding protein 2 knockout mutant strain of Japanese medaka, Oryzias latipes
Kato-Unoki, Y.; Takai, Y.; Nagano, Y.; Matsunaga, S.; Enoki, S.; Takamura, T.; Kim, S.; Kinoshita, M.; Kitano, T.; Shimasaki, Y.; Oshima, Y.
10.1101/2020.04.19.048728 — pharmacology and toxicology — Posted on 2020-04-20
1889 Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice
Sawada, H.; Franklin, M. K.; Moorleghen, J. J.; Howatt, D. A.; Kukida, M.; Lu, H. S.; Daugherty, A.
10.1101/2020.04.18.048298 — pathology — Posted on 2020-04-20
1893 Combining In Vivo Corneal Confocal Microscopy with Deep Learning-based Analysis Reveals Sensory Nerve Fiber Loss in Acute SIV Infection
McCarron, M. E.; Weinberg, R. L.; Izzi, J. M.; Queen, S. E.; Misra, S. L.; Russakoff, D. B.; Oakley, J.; Mankowski, J.
10.1101/2020.04.19.048926 — neuroscience — Posted on 2020-04-20
1895 Rapid 'multi-directed' cholinergic transmission at central synapses
Sethuramanujam, S.; Matsumoto, A.; McIntosh, J. M.; Jing, M.; Li, Y.; Berson, D.; Yonehara, K.; Awatramani, G. B.
10.1101/2020.04.18.048330 — neuroscience — Posted on 2020-04-20
1901 NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis
Kharel, P.; Singhal, N. K.; West, N.; Rana, J.; Smith, L.; Freeman, E.; Chattopadhyay, A.; McDonough, J.; Basu, S.
10.1101/2020.04.19.049494 — molecular biology — Posted on 2020-04-20
1913 Tmed2 regulates Smoothened trafficking and Hedgehog signalling
Di Minin, G.; Dumeau, C.-E.; Grison, A.; Chan, W.; Monfort, A.; Jerome-Majewska, L. A.; Wutz, A.
10.1101/2020.04.20.049957 — cell biology — Posted on 2020-04-20
1914 PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma
Gizaw, N. Y.; Kallio, P.; Punger, T.; Kinnunen, M.; Gucciardo, E.; Lehti, K.; Haglund, C.; Bohling, T.; Varjosalo, M.; Sampo, M.; Alitalo, K.; Kivela, R.
10.1101/2020.04.19.045989 — cancer biology — Posted on 2020-04-20
1918 PAWER: Protein Array Web ExploreR
Fishman, D.; Kuzmin, I.; Adler, P.; Vilo, J.; Peterson, H.
10.1101/692905 — bioinformatics — Posted on 2020-04-20
1921 Comprehensive Chromosome End Remodeling During Programmed DNA Elimination
Wang, J.; Veronezi, G. M. B.; Kang, Y.; Zagoskin, M.; O'Toole, E. T.; Davis, R. E.
10.1101/2020.04.18.047035 — genomics — Posted on 2020-04-19
1923 An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity
Luna, L. A.; Lesecq, Z.; White, K. A.; Hoang, A.; Scott, D. A.; Zagnitko, O.; Bobkov, A. A.; Barber, D. L.; Schiffer, J. M.; Isom, D. G.; Sohl, C. D.
10.1101/2020.04.19.049387 — biochemistry — Posted on 2020-04-20
1924 PRP4K is a haploinsufficient tumour suppressor negatively regulated during epithelial-to-mesenchymal transition
Clarke, L. E.; Van Iderstine, C.; Mathavarajah, S.; Bera, A.; Bydoun, M.; Cook, A.; Lewis, S. M.; Dellaire, G.
10.1101/2020.04.19.043851 — cancer biology — Posted on 2020-04-19
1927 Gabra2 is a genetic modifier of Dravet syndrome in mice
Hawkins, N. A.; Nomura, T.; Duarte, S. E.; Williams, R. W.; Homanics, G. E.; Mulligan, M. K.; Contractor, A.; Kearney, J. A.
10.1101/2020.04.19.048546 — genetics — Posted on 2020-04-19
1928 Neuronal adaptation during the prolonged cognitive task improves visual stimulus processing
Maksimenko, V. A.; Frolov, N. S.; Kuc, A.; Hramov, A. E.; Pisarchik, A. N.; Lebedev, M.
10.1101/2020.04.07.029959 — neuroscience — Posted on 2020-04-19
1929 Aβ oligomers induce sex-selective pathophysiological mGluR5 signaling in Alzheimer mice
Abd-Elrahman, K. S.; Albaker, A.; de Souza, J. M.; Ribeiro, F. M.; Schlossmacher, M. G.; Tiberi, M.; Hamilton, A.; Ferguson, S. S. G.
10.1101/803262 — neuroscience — Posted on 2020-04-19
1931 Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins
Zhang, Y.; Zhao, W.; Mao, Y.; Wang, S.; Zhong, Y.; Su, T.; Gong, M.; Du, D.; Lu, X.; Cheng, J.; Yang, H.
10.1101/2020.03.28.013276 — biochemistry — Posted on 2020-04-19
1933 The Na+/K+ ATPase Regulates Glycolysis and Defines Immunometabolism in Tumors
Sanderson, S. M.; Xiao, Z.; Wisdom, A. J.; Bose, S.; Liberti, M. V.; Reid, M. A.; Hocke, E.; Gregory, S. G.; Kirsch, D. G.; Locasale, J. W.
10.1101/2020.03.31.018739 — cancer biology — Posted on 2020-04-19
1935 Synaptic vesicles transiently dock to refill release sites
Kusick, G. F.; Chin, M.; Raychaudhuri, S.; Lippmann, K.; Adula, K. P.; Hujber, E. J.; Vu, T.; Davis, M. W.; Jorgensen, E. M.; Watanabe, S.
10.1101/509216 — neuroscience — Posted on 2020-04-19
1937 Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
Heer, C. D.; Sanderson, D. J.; Alhammad, Y. M. O.; Schmidt, M. S.; Trammell, S. A. J.; Perlman, S.; Cohen, M. S.; Fehr, A. R.; Brenner, C.
10.1101/2020.04.17.047480 — microbiology — Posted on 2020-04-19
1938 Comparative ACE2 variation and primate COVID-19 risk
Melin, A. D.; Janiak, M. C.; Marrone, F.; Arora, P. S.; Higham, J. P.
10.1101/2020.04.09.034967 — genetics — Posted on 2020-04-19
1939 Divergence in hormone signaling drives local adaptation and intrinsic reproductive isolation
Wilkinson, M. J.; Roda, F.; Walter, G. M.; James, M. E.; Nipper, R.; Walsh, J.; Allen, S. L.; Bernal, D. M.; North, H. L.; Beveridge, C. A.; Ortiz-Barrientos, D.
10.1101/845354 — evolutionary biology — Posted on 2020-04-19
1940 CovProfile: profiling the viral genome and gene expressions of SARS-COV-2
Yu, Y.; Li, Z.; Li, Y.; Yu, L.; Jia, W.; Jiang, Y.; Ye, F.; Li, S. C.
10.1101/2020.04.05.026146 — bioinformatics — Posted on 2020-04-19
1941 Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially-infected epithelial cells
Bastounis, E. E.; Alcade, F. S.; Radhakrishnan, P.; Engstrom, P.; Gomez Benito, M. J.; Oswald, M. S.; Smith, J. G.; Welch, M.; Garcia-Aznar, J. M.; Theriot, J. A.
10.1101/2020.01.22.915140 — microbiology — Posted on 2020-04-19
1943 Generating Digital Twins with Multiple Sclerosis Using Probabilistic Neural Networks
Walsh, J. R.; Smith, A. M.; Pouliot, Y.; Li-Bland, D.; Loukianov, A.; Fisher, C. K.; Multiple Sclerosis Outcome Assessments Consortium,
10.1101/2020.02.04.934679 — bioinformatics — Posted on 2020-04-19
1944 Differences in directed functional brain connectivity related to age, sex and mental health
Lund, M. J.; Alnaes, D.; Schwab, S.; van der Meer, D.; Andreassen, O. A.; Westlye, L. T.; Kaufmann, T.
10.1101/799593 — neuroscience — Posted on 2020-04-19
1946 Rapid development of an inactivated vaccine for SARS-CoV-2
Gao, Q.; Bao, L.; Mao, H.; Wang, L.; Xu, K.; Yang, m.; Li, Y.; Zhu, L.; Wang, N.; Lv, Z.; Gao, H.; Ge, X.; Kan, B.; Hu, Y.; Liu, J.; Cai, F.; Jiang, D.; Yin, Y.; Qin, C.; Li, J.; Gong, X.; Lou, X.; Shi, W.; Wu, D.; Zhang, H.; Zhu, L.; Deng, W.; Li, Y.; Lu, J.; Li, C.; Wang, X.; Yin, W.; Zhang, Y.; Qin, C.
10.1101/2020.04.17.046375 — microbiology — Posted on 2020-04-19
1948 A dynamic nomenclature proposal for SARS-CoV-2 to assist genomic epidemiology
Rambaut, A.; Holmes, E. C.; Hill, V.; OToole, A.; McCrone, J.; Ruis, C.; du Plessis, L.; Pybus, O.
10.1101/2020.04.17.046086 — microbiology — Posted on 2020-04-19
1949 Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes
Brown, J. R.; O'Sullivan, D.; Pereira, R. P.; Whale, A. S.; Busby, E.; Huggett, J.; Harris, K.
10.1101/2020.04.17.047118 — microbiology — Posted on 2020-04-19
1950 Broad and differential animal ACE2 receptor usage by SARS-CoV-2
Zhao, X.; Chen, D.; Szabla, R.; Zheng, M.; Li, G.; Du, P.; Zheng, S.; Li, X.; Song, C.; Li, R.; Guo, J.-T.; Junop, M.; Zeng, H.; Lin, H.
10.1101/2020.04.19.048710 — microbiology — Posted on 2020-04-19
1952 Abnormal AMPAR-mediated synaptic plasticity, cognitive and autistic-like behaviors in a missense Fmr1 mutant mouse model of Fragile X syndrome
Prieto, M.; Folci, A.; Poupon, G.; Schiavi, S.; Buzzelli, V.; Francois, U.; Pousinha, P.; Lattuada, N.; Abelanet, S.; Pronot, M.; Castagnola, S.; Chafai, M.; Khayachi, A.; Brau, F.; Deval, E.; Francolini, M.; Bardoni, B.; Humeau, Y.; Trezza, V.; Martin, S.
10.1101/2020.04.19.048819 — neuroscience — Posted on 2020-04-19
1953 Endosomal spatio-temporal modulation of the cortical RhoA zone conditions epithelial cell organization
Gaston, C.; De Beco, S.; Doss, B.; Meng, P.; Gauquelin, E.; D'Alessandro, J.; Lim, C. T.; Ladoux, B.; Delacour, D.
10.1101/2020.04.19.044891 — cell biology — Posted on 2020-04-19
1954 Raman mapping glucose metabolites during human mesenchymal stem cell adipogenesis
Hobley, J. D.; Subramanian, G. S.; Nurcombe, V.; Gorelik, S.; In Yee, P.; Stylianou, C.; Cool, S.; Fernig, D. G.; Lear, M. J.
10.1101/2020.04.19.048827 — cell biology — Posted on 2020-04-19
1956 An in vivo inflammatory loop potentiates KRAS blockade
Arendt, K. A.; Ntaliarda, G.; Armenis, V.; Kati, D.; Henning, C.; Giotopoulou, G.; Pepe, M. A.; Klotz, L. V.; Lamort, A. S.; Hatz, R. A.; Kobold, S.; Stathopoulos, G. T.
10.1101/629139 — cancer biology — Posted on 2020-04-19
1957 Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants
Popp, B.; Erber, R.; Kraus, C.; Vasileiou, G.; Hoyer, J.; Burghaus, S.; Hartmann, A.; Beckmann, M. W.; Reis, A.; Agaimy, A.
10.1101/663609 — pathology — Posted on 2020-04-19
1958 Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study
Toennesen, S.; Kaufmann, T.; de Lange, A.-M.; Richard, G.; Doan, N. T.; Alnaes, D.; van der Meer, D.; Rokicki, J.; Moberget, T.; Maximov, I. I.; Agartz, I.; Aminoff, S. R.; Beck, D.; Barch, D.; Beresniewicz, J.; Fatouros Bergman, H.; Cervenka, S.; Craven, A.; Flyckt, L.; Gurholt, T. P.; Haukvik, U. K.; Hugdahl, K.; Johnsen, E.; Jonsson, E. G.; Kolskaar, K. K.; Kompus, K.; Kroken, R. A.; Lagerberg, T. V.; Loeberg, E.-M.; Nordvik, J. E.; Sanders, A.-M.; Ulrichsen, K. M.; Andreassen, O. A.; Westlye, L. T.
10.1101/607754 — neuroscience — Posted on 2020-04-19
1959 Sequencing, de novo assembly and annotation of the genome of the scleractinian coral, Pocillopora acuta
Vidal-Dupiol, J.; Chaparro, C.; Pratlong, M.; Pontarotti, P.; Grunau, C.; Mitta, G.
10.1101/698688 — genomics — Posted on 2020-04-19
1960 Systematic analysis of aberrances of ferroptosis reveals its potential functional roles in cancer
Liu, Z.; Zhao, Q.; Zuo, Z.; Yuan, S.-Q.; Yu, K.; Zhang, Q.; Zhang, X.; Sheng, H.; Ju, H.-Q.; Cheng, H.; Wang, F.; Xu, R.-H.; Liu, Z.-X.
10.1101/765826 — cancer biology — Posted on 2020-04-19
1961 ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damage
Bailey, P. S.; Ortmann, B. M.; Houghton, J. W.; Costa, A. S. H.; Antrobus, R.; Frezza, C.; Nathan, J. A.
10.1101/2020.04.18.048082 — cell biology — Posted on 2020-04-18
1962 Towards an individualised neural assessment of receptive language in children
Petit, S.; Badcock, N. A.; Grootswagers, T.; Rich, A. N.; Brock, J.; Nickels, L.; Moerel, D.; Dermody, N.; Yau, S.; Schmidt, E.; Woolgar, A.
10.1101/566752 — animal behavior and cognition — Posted on 2020-04-19
1963 Expanding the diversity of bacterioplankton isolates and modeling isolation efficacy with large scale dilution-to-extinction cultivation
Henson, M. W.; Lanclos, V. C.; Pitre, D. M.; Weckhorst, J. L.; Lucchesi, A. M.; Cheng, C.; Temperton, B.; Thrash, C.
10.1101/2020.04.17.046896 — microbiology — Posted on 2020-04-18
1967 Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling
Mak, K. H.; Zhao, Q.; Hu, P.-W.; Au-Yeung, C.-L.; Yang, J.; Duraine, L.; Yu, Y.; Abu-Remaileh, M.; Sabatini, D.; Wang, J.; Wang, M. C.
10.1101/2020.04.18.048561 — cell biology — Posted on 2020-04-18
1971 Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of 2019-nCov entry
Mei, Z.; Bingpeng, L.; Hongbin, G.; Xinhong, W.; Kaibin, W.; Mingxiao, L.; Chang, L.; Jianming, C.; Learn-han, L.; Cuiling, Q.; Linhu, G.; Lijing, W.
10.1101/2020.04.18.047951 — pathology — Posted on 2020-04-18
1974 Functional MRI of large scale activity in behaving mice
Fonseca, M. S.; Bergomi, M. G.; Mainen, Z. F.; Shemesh, N.
10.1101/2020.04.16.044941 — neuroscience — Posted on 2020-04-18
1975 Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
Bakhurin, K. I.; Li, X.; Friedman, A. D.; Lusk, N. A.; Watson, G. D.; Kim, N.; Yin, H. H.
10.1101/2019.12.26.889030 — neuroscience — Posted on 2020-04-18
1977 Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
Heer, C. D.; Sanderson, D. J.; Alhammad, Y. M. O.; Schmidt, M. S.; Trammell, S. A. J.; Perlman, S.; Cohen, M. S.; Fehr, A. R.; Brenner, C.
10.1101/2020.04.17.047480 — microbiology — Posted on 2020-04-18
1978 Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder
Lacerda Mariano, L.; Rousseau, M.; Varet, H.; Legendre, R.; Gentek, R.; Saenz Coronilla, J.; Bajenoff, M.; Gomez-Perdiguero, E.; Ingersoll, M. A.
10.1101/2020.04.18.048074 — immunology — Posted on 2020-04-18
1980 Regional genomic heritability mapping for agronomic traits in sugarcane
Vidigal, P. M. P.; Momen, M.; Costa, P. M. A.; Barbosa, M. H. P.; Morota, G.; Peternelli, L. A.
10.1101/2020.04.16.045310 — genomics — Posted on 2020-04-18
1981 Ancestry-Specific Predisposing Germline Variants in Cancer
Oak, N.; Cherniak, A. D.; Mashl, R. J.; TCGA Analysis Network, ; Hirsch, F. R.; Ding, L.; Beroukhim, R.; Gumus, Z.; Plon, S. E.; Huang, K.-l.
10.1101/2020.04.14.032557 — genomics — Posted on 2020-04-18
1982 Genome architecture and transcription data reveal allelic bias during the cell cycle
Lindsly, S. M.; Jia, W.; Chen, H.; Ronquist, S.; Chen, C.; Wen, X.; Li, S. C.; Wicha, M.; Rehemtulla, A.; Muir, L.; Rajapakse, I.
10.1101/2020.03.15.992164 — genomics — Posted on 2020-04-18
1984 Convergent evolution of conserved mitochondrial pathways underlies repeated adaptation to extreme environments
Greenway, R.; Barts, N.; Henpita, C.; Brown, A. P.; Arias-Rodriguez, L.; Rodriguez Pena, C. M.; Arndt, S.; Lau, G. Y.; Murphy, M. P.; Wu, L.; Lin, D.; Shaw, J. H.; Kelley, J. L.; Tobler, M.
10.1101/2020.02.24.959916 — evolutionary biology — Posted on 2020-04-18
1989 Exploring the niche concept in a simple metaorganism
Deines, P.; Hammerschmidt, K.; Bosch, T. C. G.
10.1101/814798 — ecology — Posted on 2020-04-18
1992 Macrophage Function is Regulated by NPM1-Mediated 2'-O-Methylation
Sportoletti, P.; Nachmani, D.; Riccardi, L.; Khanna-Gupta, A.; Chen, J.; Marra, A.; Berliner, N.; Clohessy, J. G.; Pandolfi, P. P.
10.1101/2020.04.18.048223 — cell biology — Posted on 2020-04-18
1993 Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex
Bhargava, H. K.; Tabata, K.; Byck, J. K.; Hamasaki, M.; Farrell, D. P.; Anishchenko, I.; DiMaio, F.; Im, Y.-J.; Yoshimori, T.; Hurley, J. H.
10.1101/2020.04.18.048462 — cell biology — Posted on 2020-04-18
1995 Epigenetic regulator BMI1 promotes fusion-positive rhabdomyosarcoma proliferation and constitutes a novel therapeutic target
Shields, C. E.; Potlapalli, S.; Cuya-Smith, S. M.; Chappell, S. K.; Chen, D.; Martinez, D.; Pogoriler, J.; Rathi, K. S.; Patel, S. A.; Maris, J. M.; Schnepp, R. W.
10.1101/2020.04.18.048355 — cancer biology — Posted on 2020-04-18
1999 Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice
Bobe, A. M.; Miyoshi, J.; Moore, P.; Devkota, S.; Leone, V.; Martinez, K.; Theriault, B. R.; Musch, M. W.; Wasserfall, C.; Atkinson, M.; Rhodes, C. J.; Chang, E. B.
10.1101/2020.04.18.048272 — physiology — Posted on 2020-04-18
2002 Regulation of angiotensin converting enzyme 2 (ACE2) in obesity: implications for COVID-19
Al Heialy, S.; Hachim, M. Y.; Senok, A.; Abou Tayoun, A.; Hamoudi, R.; Alsheikh-Ali, A.; Alheialy, Q.
10.1101/2020.04.17.046938 — immunology — Posted on 2020-04-18
2003 Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
Heer, C. D.; Sanderson, D. J.; Alhammad, Y. M. O.; Schmidt, M. S.; Trammell, S. A. J.; Perlman, S.; Cohen, M. S.; Fehr, A. R.; Brenner, C.
10.1101/2020.04.17.047480 — microbiology — Posted on 2020-04-18
2007 An in silico map of the SARS-CoV-2 RNA Structurome
Andrews, R. J.; Peterson, J. M.; Haniff, H. F.; Chen, J.; Williams, C.; Greffe, M.; Disney, M. D.; Moss, W. N.
10.1101/2020.04.17.045161 — bioinformatics — Posted on 2020-04-18
2009 Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma
Kong, Y.; Xu, C.; Cui, C.; Yang, W.; Yang, S.; Chi, Z.; Sheng, X.; Si, L.; Xie, Y.; Yu, J.; Chen, X.; Wang, S.; Hu, J.; Zheng, F.; Zhou, W.; Yu, R.; Guo, J.
10.1101/2020.04.18.047852 — immunology — Posted on 2020-04-18
2010 NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotype
Subbalakshmi, A. R.; Kundnani, D.; Biswas, K.; Ghosh, A.; Hanash, S.; Tripathi, S. C.; Jolly, M. K.
10.1101/2020.04.18.047803 — cancer biology — Posted on 2020-04-18
2012 Transient disruption of the inferior parietal lobule impairs the ability to attribute intention to action
Patri, J.-F.; Cavallo, A.; Pullar, K.; Soriano, M.; Valente, M.; Koul, A.; Avenanti, A.; Panzeri, S.; Becchio, C.
10.1101/2020.04.18.047787 — neuroscience — Posted on 2020-04-18
2014 Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia
Wang, B.; Kong, L.; BABU, D.; Choudhary, R.; Fam, W.; Tng, J. Q.; Goh, Y.; Liu, X.; Song, F. F.; Chia, P.; Chan, M. C.; An, O.; Tham, C. Y.; Benoukraf, T.; Yang, H.; Wang, W.; Chng, W. J.; Tenen, D.; Fullwood, M. J.
10.1101/2020.04.18.047738 — cancer biology — Posted on 2020-04-18
2015 Structured sampling of olfactory input by the fly mushroom body
Zheng, Z.; Li, F.; Fisher, C.; Ali, I. J.; Sharifi, N.; Calle-Schuler, S.; Hsu, J.; Masoodpanah, N.; Kmecova, L.; Kazimiers, T.; Perlman, E.; Nichols, M.; Li, P. H.; Jain, V.; Bock, D. D.
10.1101/2020.04.17.047167 — neuroscience — Posted on 2020-04-18
2016 Responses to Visual Speech in Human Posterior Superior Temporal Gyrus Examined with iEEG Deconvolution
Metzger, B. A.; Magnotti, J. S.; Wang, Z.; Nesbitt, E.; Karas, P. J.; Yoshor, D.; Beauchamp, M. S.
10.1101/2020.04.16.045716 — neuroscience — Posted on 2020-04-18
2019 The high-energy transition state of a membrane transporter
Huysmans, G. H. M.; Ciftci, D.; Wang, X.; Blanchard, S. C.; Boudker, O.
10.1101/2020.04.17.047373 — biophysics — Posted on 2020-04-18
2020 Fitness and community feedbacks: the two axes that drive long-term invasion impacts
Arnoldi, J.-F.; Barbier, M.; Kelly, R.; Barabas, G.; Jackson, A. L.
10.1101/705756 — ecology — Posted on 2020-04-18
2022 Dense encoding of developmental regulatory information may constrain evolvability
Fuqua, T.; Jordan, J.; van Breugel, M. E.; Halavatyi, A.; Tischer, C.; Polidoro, P.; Abe, N.; Tsai, A.; Mann, R. S.; Stern, D. L.; Crocker, J.
10.1101/2020.04.17.046052 — evolutionary biology — Posted on 2020-04-18
2025 Complex dynamics of choice during operant extinction and a simple associative learning account
Donoso, J. R.; Packheiser, J.; Pusch, R.; Lederer, Z.; Walther, T.; Güntürkün, O.; Cheng, S.
10.1101/2020.04.17.046136 — animal behavior and cognition — Posted on 2020-04-18
2026 Role of TRPV1 in colonic mucin production and gut microbiota profile
Kumar, V.; Mahajan, N.; Khare, P.; Kondepudi, K. K.; Bishnoi, M.
10.1101/2020.04.17.046011 — physiology — Posted on 2020-04-18
2027 Human-lineage-specific genomic elements: relevance to neurodegenerative disease and APOE transcript usage
Chen, Z.; Zhang, D.; Reynolds, R. H.; Gustavsson, E. K.; Garcia Ruiz, S.; D'Sa, K.; Fairbrother-Browne, A.; Vandrovcova, J.; Genomics Consortium (IPDGC), I. P. D.; Hardy, J.; Houlden, H.; Gagliano Taliun, S. A.; Botia, J. A.; Ryten, M.
10.1101/2020.04.17.046441 — neuroscience — Posted on 2020-04-18
2029 Disrupted copper availability in sporadic ALS: Implications for CuII(atsm) as a treatment option
Hilton, J. B.; Kysenius, K.; Liddell, J. R.; Rautengarten, C.; Mercer, S. W.; Paul, B.; Beckman, J. S.; McLean, C. A.; White, A. R.; Donnelly, P. S.; Bush, A. I.; Hare, D. J.; Roberts, B. R.; Crouch, P.
10.1101/2020.04.17.047704 — neuroscience — Posted on 2020-04-18
2033 Selective amplification of ipRGC signals accounts for interictal photophobia in migraine
McAdams, H. M.; Kaiser, E. A.; Igdalova, A.; Haggerty, E. B.; Cucchiara, B.; Brainard, D. H.; Aguirre, G. K.
10.1101/2020.04.17.047290 — neuroscience — Posted on 2020-04-18
2035 Expanding the diversity of bacterioplankton isolates and modeling isolation efficacy with large scale dilution-to-extinction cultivation
Henson, M. W.; Lanclos, V. C.; Pitre, D. M.; Weckhorst, J. L.; Lucchesi, A. M.; Cheng, C.; Temperton, B.; Thrash, C.
10.1101/2020.04.17.046896 — microbiology — Posted on 2020-04-18
2037 RNA-seq of Human T-Cells After Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Novel Regulator of T-Cell Alloimmunity
Peltier, D.; Radosevich, M.; Hou, G.; Zajac, C.; Oravecz-Wilson, K.; Sokol, D.; Henig, I.; Wu, J.; Kim, S.; Taylor, A.; Fujiwara, H.; Sun, Y.; Reddy, P.
10.1101/2020.04.16.045567 — immunology — Posted on 2020-04-18
2038 Genotypic characterization of the U.S. peanut core collection
Otyama, P. I.; Kulkarni, R.; Chamberlin, K.; Ozias-Akins, P. K.; Chu, J.; Lincoln, L. M.; MacDonald, G. E.; Anglin, N. L.; Dash, S.; Bertioli, D.; Fernandez-Baca, D. F.; Graham, M. A.; Cannon, S. B.; Cannon, E. K.
10.1101/2020.04.17.047019 — genomics — Posted on 2020-04-18
2039 Extensive hybridization between pig and human Ascaris identifies a highly interbred species complex infecting humans
Easton, A. V.; Gao, S.; Lawton, S. P.; Bennuru, S.; Khan, A.; Dahlstrom, E.; Oliveira, R. G.; Kepha, S.; Porcella, S. F.; Webster, J. P.; Anderson, R. M.; Grigg, M. E.; Davis, R. E.; Wang, J.; Nutman, T. B.
10.1101/2020.04.17.047407 — genomics — Posted on 2020-04-18
2040 A flexible repertoire of transcription factor binding sites and diversity threshold determines enhancer activity in embryonic stem cells
Singh, G.; Mullany, S.; Moorthy, S. D.; Zhang, R.; Mehdi, T. F.; Shchuka, V. M.; Tian, R.; Moses, A.; Mitchell, J. A.
10.1101/2020.04.17.046664 — genomics — Posted on 2020-04-18
2043 Detecting turnover among complex communities using null models: A case study with sky-island haemosporidian parasites
Barrow, L. N.; Bauernfeind, S. M.; Cruz, P. A.; Williamson, J. L.; Wiley, D. L.; Ford, J. E.; Baumann, M. J.; Brady, S. S.; Chavez, A. N.; Gadek, C. R.; Galen, S. C.; Johnson, A. B.; Mapel, X. M.; Marroquin-Flores, R. A.; Martinez, T. E.; McCullough, J. M.; McLaughlin, J. E.; Witt, C. C.
10.1101/2020.04.17.046631 — ecology — Posted on 2020-04-18
2045 Classes for the masses: Systematic classification of unknowns using fragmentation spectra
Dührkop, K.; Nothias, L.-F.; Fleischauer, M.; Ludwig, M.; Hoffmann, M. A.; Rousu, J.; Dorrestein, P. C.; Böcker, S.
10.1101/2020.04.17.046672 — bioinformatics — Posted on 2020-04-18
2048 TMEM16K is an interorganelle regulator of endosomal sorting
Petkovic, M.; Oses-Prieto, J. A.; Burlingame, A.; Jan, L.; Jan, Y. N.
10.1101/2020.04.17.046961 — cell biology — Posted on 2020-04-18
2052 Immune-challenged vampire bats produce fewer contact calls
Stockmaier, S.; Bolnick, D. I.; Page, R. A.; Josic, D.; Carter, G. G.
10.1101/2020.04.17.046730 — animal behavior and cognition — Posted on 2020-04-18
2053 What makes Hemidactylus invasions successful? A case study on the island of Curacao.
Lamb, A. D.; Lippi, C. A.; Watkins-Colwell, G. J.; Jones, A.; Warren, D.; Iglesias, T. L.; Brandley, M.; Neagle, C.; Dornburg, A.
10.1101/2020.04.17.047209 — zoology — Posted on 2020-04-18
2055 α-Synuclein perturbs in vivo neural activity following seeding in the olfactory bulb
Kulkarni, A. S.; Cortijo, M. d. M.; Roberts, E. R.; Suggs, T. L.; Stover, H. B.; Pena-Bravo, J. I.; Steiner, J. A.; Luk, K. C.; Brundin, P.; Wesson, D. W.
10.1101/2020.04.17.045013 — neuroscience — Posted on 2020-04-18
2057 Behavioral and neural variability of naturalistic arm movements
Peterson, S. M.; Singh, S. H.; Wang, N. X. R.; Rao, R. P. N.; Brunton, B. W.
10.1101/2020.04.17.047357 — neuroscience — Posted on 2020-04-18
2059 Light effects on circadian and homeostatic regulation: alertness increases independent of time awake.
Lok, R.; Woelders, T.; van Koningsveld, M. J.; Oberman, K.; Fuhler, S. G.; Beersma, D. G. M.; Hut, R. A.
10.1101/2020.04.17.047423 — neuroscience — Posted on 2020-04-18
2061 Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation
Borgman, K. J. E.; Florez-Grau, G.; Ricci, M. A.; Manzo, C.; Lakadamyali, M.; Cambi, A.; Benitez-Ribas, D.; Campelo, F.; Garcia-Parajo, M. F.
10.1101/2020.04.16.044974 — immunology — Posted on 2020-04-18
2062 Comparative genome and transcriptome analyses revealing interspecies variations in the expression of fungal biosynthetic gene clusters
Takahashi, H.; Umemura, M.; Shimizu, M.; Ninomiya, A.; Kusuya, Y.; Urayama, S.-i.; Watanabe, A.; Kamei, K.; Yaguchi, T.; Hagiwara, D.
10.1101/2020.04.17.047639 — genomics — Posted on 2020-04-18
2065 Topsentinol L Trisulfate, a new Marine Natural Product, that Targets Basal-like and Claudin-low Breast Cancers
El-Chaar, N. N.; Smith, T. E.; Shreshtha, G.; Piccolo, S. R.; Harper, M. K.; Van Wagoner, R. M.; Lu, Z.; Venancio, A. R.; Ireland, C. M.; Bild, A. H.; Moos, P. J.
10.1101/2020.04.17.047555 — cancer biology — Posted on 2020-04-18
2068 Potentiating TMEM16A channel function has no effect on airway goblet cells or bronchial and pulmonary vascular smooth muscle function
Danahay, H.; Fox, R.; Lilley, S.; Charlton, H.; Adley, K.; Christie, L.; Ansari, E.; Ehre, C.; Flen, A.; Tuvim, M. J.; Dickey, B. F.; Williams, C.; Beaudoin, S.; Collingwood, S. P.; Gosling, M.
10.1101/2020.04.17.046177 — physiology — Posted on 2020-04-18
2069 In situ impedance measurements on postmortem porcine brain
Possner, L.; Laukner, M.; Wilhelmy, F.; Lindner, D.; Pliquett, U.; Petkovic, B.; Ziolkowski, M.; Knoesche, T.; Weise, K.
10.1101/2020.04.17.029728 — neuroscience — Posted on 2020-04-18
2071 Locus coeruleus patterns differentially modulate learning and valence in rat via the ventral tegmental area and basolateral amygdala respectively
Ghosh, A.; Massaeli, F.; Power, K. D.; Omoluabi, T.; Torraville, S. E.; Pritchett, J. B.; Sepahvand, T.; Strong, V. M.; Reinhardt, C.; Chen, X.; Martin, G. M.; Harley, C. W.; Yuan, Q.
10.1101/2020.04.17.047126 — neuroscience — Posted on 2020-04-18
2072 Lisdexamfetamine alters BOLD-fMRI activations induced by odor cues in impulsive children
HidalgoTobon, S. S.; Dies Suarez, P.; Barragan Perez, E.; Hernandez Lopez, J. M.; Garcia, J.; de Celis Alonso, B.
10.1101/2020.04.17.046888 — neuroscience — Posted on 2020-04-18
2074 Disordered Proteins Enable Histone Chaperoning on the Nucleosome
Heidarsson, P. O.; Mercadante, D.; Sottini, A.; Nettels, D.; Borgia, M. B.; Borgia, A.; Kilic, S.; Fierz, B.; Best, R. B.; Schuler, B.
10.1101/2020.04.17.046243 — biophysics — Posted on 2020-04-18
2076 ReactomeGSA - Efficient Multi-Omics Comparative Pathway Analysis
Griss, J.; Viteri, G.; Sidiropoulos, K.; Nguyen, V.; Fabregat, A.; Hermjakob, H.
10.1101/2020.04.16.044958 — bioinformatics — Posted on 2020-04-18
2077 A comprehensive benchmarking of WGS-based structural variant callers
Sarwal, V.; Niehus, S.; Ayyala, R.; Chang, S.; Lu, A.; Darci-Maher, N.; Littman, R.; Wesel, E.; Castellanos, J.; Chikka, R.; Distler, M. G.; Eskin, E.; Flint, J.; Mangul, S.
10.1101/2020.04.16.045120 — bioinformatics — Posted on 2020-04-18
2080 Organ-on-a-chip model of vascularized human bone marrow niches
Glaser, D. E.; Curtis, M. B.; Sariano, P. A.; Rollins, Z. A.; Shergill, B. S.; Anand, A.; Deely, A. M.; Shirure, V. S.; Anderson, L.; Lowen, J. M.; Ng, N. R.; Weilbaecher, K.; Link, D. C.; George, S. C.
10.1101/2020.04.17.039339 — bioengineering — Posted on 2020-04-18
2081 Elucidation and refinement of synthetic receptor mechanisms
Edelstein, H. I.; Donahue, P. S.; Muldoon, J. J.; Kang, A. K.; Dolberg, T. B.; Battaglia, L. M.; Allchin, E. R.; Hong, M.; Leonard, J. N.
10.1101/2020.04.16.045039 — synthetic biology — Posted on 2020-04-18
2087 Powered flight potential approached by wide range of close avian relatives but achieved selectively
Pei, R.; Pittman, M.; Goloboff, P. A.; Dececchi, T. A.; Habib, M. B.; Kaye, T. G.; Larsson, H. C.; Norell, M. A.; Brusatte, S. L.; Xu, X.
10.1101/2020.04.17.046169 — paleontology — Posted on 2020-04-18
2088 Comprehension of computer code relies primarily on domain-general executive resources
Ivanova, A. A.; Srikant, S.; Sueoka, Y.; Kean, H. H.; Dhamala, R.; O'Reilly, U.-M.; Bers, M. U.; Fedorenko, E.
10.1101/2020.04.16.045732 — neuroscience — Posted on 2020-04-18
2090 Taxonomy of neural oscillation events in primate auditory cortex
Neymotin, S. A.; Barczak, A.; O'Connell, M. N.; McGinnis, T.; Markowitz, N.; Espinal, E.; Griffith, E.; Anwar, H.; Dura-Bernal, S.; Lytton, W. W.; Jones, S. R.; Bickel, S.; Lakatos, P.
10.1101/2020.04.16.045021 — neuroscience — Posted on 2020-04-18
2091 A role for the cortex in sleep-wake regulation
Krone, L. B.; Yamagata, T.; Blanco-Duque, C.; Guillaumin, M. C. C.; Kahn, M. C.; Akerman, C. J.; Hoerder-Suabedissen, A.; Molnar, Z.; Vyazovskiy, V. V.
10.1101/2020.03.17.996090 — neuroscience — Posted on 2020-04-18
2093 JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with positron emission tomography derived neurotransmitter maps
Dukart, J.; Holiga, S.; Rullmann, M.; Lanzenberger, R.; Hawkins, P. C. T.; Mehta, M. A.; Hesse, S.; Barthel, H.; Sabri, O.; Jech, R.; Eickhoff, S. B.
10.1101/2020.04.17.046300 — neuroscience — Posted on 2020-04-18
2097 Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene
Saeed, M.; Ibanez-Costa, A.; Patino Trives, A. M.; Collantes Estevez, E.; Aguirre-Zamorano, M. A.; Lopez-Pedrera, C.
10.1101/2020.04.17.047332 — genomics — Posted on 2020-04-18
2104 Horseshoe crab genomes reveal the evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication
Nong, W.; Qu, Z.; Li, Y.; Owen, T. B.; Wong, A. Y.; Yip, H. Y.; Lee, H. T.; Narayana, S.; Baril, T.; Swale, T.; Cao, J.; Chan, T. F.; Kwan, H. S.; Ngai, S. M.; Panagiotou, G.; Qian, P.-Y.; Qiu, J.-w.; Yip, K. Y.; Ismail, N.; Pati, S.; John, A.; Tobe, S. S.; Bendena, W. G.; Cheung, S. G.; Hayward, A.; Hui, J. H. L.
10.1101/2020.04.16.045815 — evolutionary biology — Posted on 2020-04-18
2106 Predicting missing links in global host-parasite networks
Farrell, M. J.; Elmasri, M.; Stephens, D. A.; Davies, T. J.
10.1101/2020.02.25.965046 — ecology — Posted on 2020-04-18
2108 Simple attributes predict the importance of plants as hosts to the richness of fungi and arthropods
Bruun, H. H.; Brunbjerg, A. K.; Dalby, L.; Flojgaard, C.; Froeslev, T. G.; Haarder, S.; Heilmann-Clausen, J.; Hoye, T. T.; Laessoe, T.; Ejrnaes, R.
10.1101/2020.04.17.046292 — ecology — Posted on 2020-04-18
2110 Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis
Uzunparmak, B.; Gao, M.; Lindemann, A.; Erikson, K.; Wang, L.; Lin, E.; Frank, S.; Gleber-Netto, F. O.; Zhao, M.; Skinner, H. D.; Newton, J.; Sikora, A. G.; Myers, J. N.; Pickering, C. R.
10.1101/2020.04.17.039040 — cancer biology — Posted on 2020-04-18
2114 Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc
Gao, S.; Valinsky, W. C.; On, N. C.; Houlihan, P. R.; Qu, Q.; Liu, L.; Xiaojing, P.; Clapham, D. E.; Yan, N.
10.1101/2020.04.16.045674 — biophysics — Posted on 2020-04-18
2115 Thermal Control of T-cell Immunotherapy
Abedi, M. H.; Lee, J.; Piraner, D. I.; Shapiro, M. G.
10.1101/2020.04.16.045146 — bioengineering — Posted on 2020-04-18
2116 Temperatures that sterilise males better predict global distributions of species than lethal temperatures
Parratt, S. R.; Walsh, B.; Metelmann, S.; White, N.; Manser, A.; Bretman, A.; Hoffmann, A. A.; Snook, R.; Price, T.
10.1101/2020.04.16.043265 — ecology — Posted on 2020-04-18
2120 First evidence of virus-like particles in the bacterial symbionts of Bryozoa
Vishnyakov, A. E.; Karagodina, N. P.; Lim-Fong, G. E.; Ivanov, P. A.; Schwaha, T. F.; Letarov, A. V.; Octrovsky, A. N.
10.1101/2020.04.16.045880 — microbiology — Posted on 2020-04-18
2122 Immune modulation to improve survival of respiratory virus infections in mice
Wali, S.; Flores, J. R.; Jaramillo, A. M.; Goldblatt, D. L.; Pantaleon Garcia, J.; Tuvim, M. J.; Dickey, B. F.; Evans, S. E.
10.1101/2020.04.16.045054 — immunology — Posted on 2020-04-18
2123 Regional genomic heritability mapping for agronomic traits in sugarcane
Vidigal, P. M. P.; Momen, M.; Costa, P. M. A.; Barbosa, M. H. P.; Morota, G.; Peternelli, L. A.
10.1101/2020.04.16.045310 — genomics — Posted on 2020-04-18
2124 CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary cells
Kluesner, M. G.; Lahr, W. S.; Lonetree, C.-L.; Smeester, B. A.; Claudio-Vazquez, P. N.; Pitzen, S. P.; Vignes, M. J.; Lee, S. C.; Bingea, S. P.; Andrew, A. A.; Webber, B. R.; Moriarity, B. S.
10.1101/2020.04.16.045336 — bioengineering — Posted on 2020-04-18
2125 Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a
Tang, D.; Xu, L.; Sheng, J.; Zhan, X.; Liu, J.; Jiang, H.; Shu, X.; Liu, X.; Zhang, T.; Jiang, L.; Zhou, C.; Li, W.; Cheng, W.; Li, Z.; Wang, K.; Lu, K.; Yan, C.; Qi, S.
10.1101/2020.04.16.045708 — biochemistry — Posted on 2020-04-18
2128 Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody
Rissanen, I.; Stass, R.; Krumm, S. A.; Seow, J.; Hulswit, R. J. G.; Paesen, G. C.; Hepojoki, J.; Vapalahti, O.; Lundkvist, A.; Reynard, O.; Volchkov, V.; Doores, K. J.; Huiskonen, J. T.; Bowden, T. A.
10.1101/2020.04.17.029876 — microbiology — Posted on 2020-04-18
2129 Mortality of native and invasive ladybirds co-infected by ectoparasitic and entomopathogenic fungi
Haelewaters, D.; Hiller, T.; Kemp, E. A.; van Wielink, P. S.; Shapiro-Ilan, D. I.; Aime, M. C.; Nedved, O.; Pfister, D. H.; Cottrell, T. E.
10.1101/2020.04.17.045930 — microbiology — Posted on 2020-04-18
2131 Transplantation of muscle stem cell mitochondria rejuvenates the bioenergetic function of dystrophic muscle
Mohiuddin, M.; Choi, J. J.; Lee, N. H.; Jeong, H. H.; Anderson, S. E.; Han, W. M.; Aliya, B.; Peykova, T. Z.; Verma, S.; Garcia, A. J.; Aguilar, C. A.; Jang, Y. C.
10.1101/2020.04.17.017822 — cell biology — Posted on 2020-04-18
2134 Structure of the TFIIIC subcomplex {tau} A provides insights into RNA polymerase III pre-initiation complex formation
Vorländer, M. K.; Jungblut, A.; Karius, K.; Baudin, F.; Grötsch, H.; Kosinski, J.; Müller, C. W.
10.1101/2020.04.17.046805 — biochemistry — Posted on 2020-04-18
2136 RootPainter: Deep Learning Segmentation of Biological Images with Corrective Annotation
Smith, A. G.; Han, E.; Petersen, J.; Olsen, N. A. F.; Giese, C.; Athmann, M.; Dresboll, D. B.; Thorup-Kristensen, K.
10.1101/2020.04.16.044461 — plant biology — Posted on 2020-04-18
2140 c-Fos-MMP-9 pathway in central amygdala mediates approach motivation but not reward consumption
Lebitko, T.; Dzik, J.; Jedrzejewska-Szmek, J.; Chaturvedi, M.; Jaworski, T.; Nikolaev, T.; Meyza, K.; Kaczmarek, L.; Knapska, E.
10.1101/2020.04.17.044792 — neuroscience — Posted on 2020-04-18
2142 The beginning of the end: a chromosomal assembly of the New World malaria mosquito ends with a novel telomere
Compton, A.; Liang, J.; Chen, C.; Lukyanchikova, V.; Qi, Y.; Potters, M.; Settlage, R.; Miller, D.; Deschamps, S.; Mao, C.; Llaca, V.; Sharakhov, I. V.; Tu, Z.
10.1101/2020.04.17.047084 — genomics — Posted on 2020-04-18
2145 Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment
Myerson, J. W.; Patel, P. N.; Habibi, N.; Walsh, L. R.; Lee, Y.-W.; Luther, D. C.; Ferguson, L. T.; Zaleski, M. H.; Zamora, M. E.; Marcos-Contreras, O. A.; Glassman, P. M.; Johnston, I.; Hood, E. D.; Shuvaeva, T.; Gregory, J. V.; Kiseleva, R. Y.; Nong, J.; Rubey, K. M.; Greineder, C. F.; Mitragotri, S.; Worthen, G. S.; Rotello, V. M.; Lahann, J.; Muzykantov, V. R.; Brenner, J. S.
10.1101/2020.04.15.037564 — bioengineering — Posted on 2020-04-18
2146 NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells
Nakano, T.; Inoue, I.; Takenaka, Y.; Ito, R.; Kotani, N.; Sato, S.; Nakano, Y.; Hirasaki, M.; Shimada, A.; Murakoshi, T.
10.1101/2020.04.17.036814 — biochemistry — Posted on 2020-04-18
2147 Cultivar-specific transcriptome and pan-transcriptome reconstruction of tetraploid potato
Petek, M.; Zagorscak, M.; Ramsak, Z.; Sanders, S.; Tomaz, S.; Tseng, E.; Zouine, M.; Coll, A.; Gruden, K.
10.1101/845818 — plant biology — Posted on 2020-04-18
2148 Three-dimensional regulation of HOXA cluster genes by a cis-element in hematopoietic stem cell and leukemia.
Wang, X. Q. D.; Gore, H.; Himadewei, P.; Feng, F.; Yang, L.; Zhou, W.; Wang, X.; Chen, C.-w.; Su, J.; Liu, J.; Pfeifer, G.; Zhang, X.
10.1101/2020.04.16.017533 — genomics — Posted on 2020-04-18
2149 Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
Yurtman, E.; Özer, O.; Yüncü, E.; Dagtas, N. D.; Koptekin, D.; Cakan, Y. G.; Özkan, M.; Akbaba, A.; Kaptan, D.; Atag, G.; Vural, K. B.; Gündem, C. Y.; Martin, L.; Kılınc, G. M.; Ghalichi, A.; Acan, S. C.; Yaka, R.; Saglıcan, E.; Lagerholm, V. K.; Krzewinska, M.; Piskin, E.; Sevketoglu, M.; Bilgin, C. C.; Atakuman, C.; Erdal, Y. S.; Sürer, E.; Lenstra, J. A.; Yorulmaz, S.; Abazari, F.; Sadati, J. H.; Baird, D.; Bıcakcı, E.; Cevik, O.; Gerritsen, F.; Özbal, R.; Götherström, A.; Somel, M.; Togan, I.; Özer, F.
10.1101/2020.04.17.033415 — evolutionary biology — Posted on 2020-04-18
2152 RefKA: A fast and efficient long-read genome assembly approach for large and complex genomes
Yuan, Y.; Bayer, P. E.; Anderson, R.; Lee, H.; Chan, C.-K. K.; Zhao, R.; Batley, J.; Edwards, D.
10.1101/2020.04.17.035287 — bioinformatics — Posted on 2020-04-18
2154 Synthetic nanobodies targeting the SARS-CoV-2 receptor-binding domain
Walter, J. D.; Hutter, C. A. J.; Zimmermann, I.; Earp, J.; Egloff, P.; Sorgenfrei, M.; Hürlimann, L. M.; Gonda, I.; Meier, G.; Remm, S.; Thavarasah, S.; Plattet, P.; Seeger, M. A.
10.1101/2020.04.16.045419 — biochemistry — Posted on 2020-04-18
2155 Omics-Based Interaction Framework - a systems model to reveal molecular drivers of synergy
Pantaleon Garcia, J.; Kulkarni, V. V.; Reese, T. C.; Wali, S.; Wase, S. J.; Zhang, J.; Singh, R.; Caetano, M. S.; Moghaddam, S. J.; Johnson, F. M.; Wang, J.; Wang, Y.; Evans, S. E.
10.1101/2020.04.16.041350 — systems biology — Posted on 2020-04-18
2156 Citrus vascular proteomics highlights the role of peroxidases and serine proteases during Huanglongbing disease progression
Franco, J.; Thapa, S. P.; Pang, Z.; Gurung, F. B.; Liebrand, T. W.; Stevens, D. M.; Ancona, V.; Wang, N.; Coaker, G.
10.1101/2020.04.05.025718 — plant biology — Posted on 2020-04-18
2158 Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load
Marks, D.; Heinen, N.; Bachmann, L.; Meermeyer, S.; Werner, M.; Gallego Vilarejo, L.; Nolte, S.; Hemmerich, P.; Bader, V.; Winklhofer, K.; Schroeder, E.; Knauer, S.; Mueller, T.
10.1101/2020.04.16.001255 — neuroscience — Posted on 2020-04-18
2160 Two dynamically distinct circuits driving inhibition in sensory thalamus
Cruikshank, S. J.; Martinez-Garcia, R. I.; Voelcker, B.; Zaltsman, J. B.; Patrick, S. L.; Stevens, T.; Connors, B. W.
10.1101/2020.04.16.044487 — neuroscience — Posted on 2020-04-18
2163 Quantification of the pace of biological aging in humans through a blood test: The DunedinPoAm DNA methylation algorithm
Belsky, D. W.; Caspi, A.; Arseneault, L.; Baccarelli, A.; Corcoran, D. L.; Gao, X.; Hannon, E.; Harrington, H. L.; Hartmann-Rasmussen, L. J.; Houts, R.; Huffman, K.; Kraus, W. E.; Kwon, D.; Mill, J.; Pieper, C.; Prinz, J.; Poulton, R.; Schwartz, J.; Sugden, K.; Vokonas, P.; Williams, B.; Moffitt, T. E.
10.1101/2020.02.05.927434 — genomics — Posted on 2020-04-18
2164 A Solanum lycopersicoides reference genome facilitates biological discovery in tomato
Powell, A. F.; Courtney, L. E.; Schmidt, M. H.- W.; Feder, A.; Vogel, A.; Xu, Y.; Lyon, D. A.; Dumschott, K. E.; McHale, M.; Suplice, R.; Bao, K.; Duhan, A.; Hallab, A.; Denton, A. K.; Mueller, L. A.; Alseekh, S.; Lie, J.; Martin, C.; Fernie, A. R.; Hind, S. R.; Martin, G. B.; Fei, Z.; Giovannoni, J. J.; Strickler, S. R.; Usadel, B.
10.1101/2020.04.16.039636 — genomics — Posted on 2020-04-18
2166 Global trends in biodiversity and ecosystem services from 1900 to 2050
Pereira, H. M.; Rosa, I. M.; Santos Martins, I.; Kim, H.; Leadley, P.; Popp, A.; van Vuuren, D.; Hurtt, G.; Anthoni, P.; Arneth, A.; Baisero, D.; Chaplin-Kramer, R.; Chini, L.; Di Fulvio, F.; Di Marco, M.; Ferrier, S.; Fujimori, S.; Guerra, C. A.; Harfoot, M. B. J.; Harwood, T.; Hasegawa, T.; Haverd, V.; Havlik, P.; Hellweg, S.; Hilbers, J.; Hill, S.; Hirata, A.; Hoskins, A. J.; Humpenoeder, F.; Janse, J.; Jetz, W.; Johnson, J. A.; Krause, A. J.; Leclere, D.; Matsui, T.; Meijer, J.; Merow, C.; Obersteiner, M.; Ohashi, H.; Poulter, B.; Purvis, A.; Quesada, B.; Rondinini, C.; Schipper, A.; Sette
10.1101/2020.04.14.031716 — ecology — Posted on 2020-04-18
2167 Microbial communities in an ultra-oligotrophic sea are more affected by season than by distancefrom shore
Haber, M.; Roth-Rosenberg, D.; Lalzar, M.; Burgsdorf, I.; Saurav, K.; Lionheart, R.; Lehahn, Y.; Aharonovich, D.; Sher, D.; Krom, M. D.; Steindler, L.
10.1101/2020.04.17.044305 — ecology — Posted on 2020-04-18
2170 The folding and unfolding behavior of ribonuclease H on the ribosome
Jensen, M. K.; Samelson, A. J.; Steward, A.; Clarke, J.; Marqusee, S.
10.1101/2020.04.16.044867 — biophysics — Posted on 2020-04-18
2181 The role of motor and environmental visual rhythms in structuring auditory cortical excitability
O'Connell, M. N.; Barczak, A.; McGinnis, T.; Mackin, K.; Mowery, T.; Schroeder, C. E.; Lakatos, P.
10.1101/2020.04.16.044917 — neuroscience — Posted on 2020-04-18
2182 Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
Li, J.; Pan, L.; Godoy, M. I.; Pembroke, W. G.; Rexach, J. E.; Condro, M. C.; Alvarado, A. G.; Harteni, M.; Chen, Y.-W.; Stiles, L.; Chen, A. Y.; Wanner, I. B.; Yang, X.; Goldman, S. A.; Geschwind, D. H.; Kornblum, H. I.; Zhang, Y.
10.1101/2020.04.17.044222 — neuroscience — Posted on 2020-04-18
2184 Neuronal Hyperexcitability is a DLK-dependent Trigger of HSV-1 Reactivation that can be Induced by IL-1
Cuddy, S.; Schinlever, A. R.; Dochnal, S.; Suzich, J.; Kundu, P.; Downs, T. K.; Farah, M.; Desai, B.; Boutell, C.; Cliffe, A. R.
10.1101/2020.04.16.044875 — microbiology — Posted on 2020-04-18
2185 IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection
Ajendra, J.; Chenery, A. L.; Parkinson, J. E.; Chan, B. H.; Pearson, S.; Colombo, S. A.; Boon, L.; Grencis, R. K.; Sutherland, T. E.; Allen, J. E.
10.1101/827899 — immunology — Posted on 2020-04-18
2186 Candida albicans exhibits distinct cytoprotective responses to anti-fungal drugs that facilitate the evolution of drug resistance
Bettauer, V.; Massahi, S.; Khurdia, S.; Costa, A.; Omran, R.; Khosravi, N.; Simpson, S.; Harb, M.; Dumeaux, V.; Whiteway, M.; Hallett, M.
10.1101/2020.01.21.914549 — genomics — Posted on 2020-04-18
2187 Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
Damas, J.; Hughes, G. M.; Keough, K. C.; Painter, C. A.; Persky, N. S.; Corbo, M.; Hiller, M.; Koepfli, K.-P.; Pfenning, A. R.; Zhao, H.; Genereux, D. P.; Swofford, R.; Pollard, K. S.; Ryder, O. A.; Nweeia, M. T.; Lindblad-Toh, K.; Teeling, E. C.; Karlsson, E. K.; Lewin, H. A.
10.1101/2020.04.16.045302 — genomics — Posted on 2020-04-18
2188 A chromosome-scale Lotus japonicus Gifu genome assembly indicates that symbiotic islands are not general features of legume genomes
Kamal, N.; Mun, T.; Reid, D.; Lin, J.-s.; Akyol, T. Y.; Sandal, N.; Asp, T.; Hirakawa, H.; Stougaard, J.; Mayer, K. F. X.; Sato, S.; Andersen, S. U.
10.1101/2020.04.17.042473 — genomics — Posted on 2020-04-18
2191 G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
Prentzell, M. T.; Rehbein, U.; Cadena Sandoval, M.; De Meulemeester, A.-S.; Baumeister, R.; Brohee, L.; Berdel, B.; Bockwoldt, M.; Carroll, B.; von Deimling, A.; Demetriades, C.; Figlia, G.; Heberle, A. M.; Heiland, I.; Holzwarth, B.; Huber, L. A.; Jaworski, J.; Kern, K.; Kopach, A.; Korolchuk, V. I.; van 't Land-Kuper, I.; Macias, M.; Nellist, M.; Pusch, S.; Reil, M.; Reintjes, A.; Reuter, F.; Scheldeman, C.; Stefan, E.; Teleman, A.; Torres-Quesada, O.; Trump, S.; de Witte, P.; Yordanov, T.; Opitz, C. A.; Thedieck, K.
10.1101/2020.04.16.044081 — cell biology — Posted on 2020-04-18
2195 Benefits of Collisional Cross Section Assisted Precursor Selection (caps-PASEF) for Cross-linking Mass Spectrometry
Steigenberger, B.; van den Toorn, H. W. P.; Bijl, E.; Greisch, J.-F.; Raether, O.; Lubeck, M.; Pieters, R. J.; Heck, A. J. R.; Scheltema, R. A.
10.1101/2020.04.16.044859 — biochemistry — Posted on 2020-04-18
2197 Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display
Bacon, K.; Blain, A.; Burroughs, M.; McArthur, N.; Rao, B. M.; Menegatti, S.
10.1101/2020.04.16.044438 — synthetic biology — Posted on 2020-04-18
2198 Informing epidemic (research) responses in a timely fashion by knowledge management - a Zika virus use case
Bauch, A.; Pellet, J.; Schleicher, T.; Yu, X.; Gelemanovic, A.; Cristella, C.; Fraaij, P. L.; Polasek, O.; Auffray, C.; Maier, D.; Koopmans, M.; de Jong, M. D.
10.1101/2020.04.17.044743 — pathology — Posted on 2020-04-18
2201 RNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization
Alqassim, E. Y.; Sharma, S.; Khan, A. N. H.; Emmons, T.; Cortes-Gomez, E.; Singel, K.; Mark, J.; Davidson, B. A.; McGray, A. R.; Liu, Q.; Litchy, B. D.; Moysich, K.; Wang, J.; Odunsi, K.; Segal, B. H.; Baysal, B. E.
10.1101/2020.03.20.988980 — immunology — Posted on 2020-04-18
2204 Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism
Gaubitz, C.; Liu, X.; Magrino, J.; Stone, N. P.; Landeck, J.; Hedglin, M.; Kelch, B. A.
10.1101/2020.02.18.953257 — biochemistry — Posted on 2020-04-18
2205 SlKIX8 and SlKIX9 are conserved repressors of organ size in the asterid species tomato
Swinnen, G.; Baekelandt, A.; De Clercq, R.; Van Doorsselaere, J.; Gonzalez, N.; Inze, D.; Goossens, A.; Pauwels, L.
10.1101/2020.02.07.938977 — plant biology — Posted on 2020-04-18
2207 Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex
Delmotte, Q.; Medina, I.; Hamze, M.; Buhler, E.; Zhang, J.; Belgacem, Y. H.; Porcher, C.
10.1101/799015 — neuroscience — Posted on 2020-04-18
2209 Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation
Nishana, M.; Ha, C.; Rodriguez-Hernaez, J.; Ranjbaran, A.; Chio, E.; Nora, E. P.; Badri, S. B.; Kloetgen, A.; Bruneau, B.; Tsirigos, A.; Skok, J. A.
10.1101/2019.12.14.874560 — genomics — Posted on 2020-04-18
2213 IDseq - An Open Source Cloud-based Pipeline and Analysis Service for Metagenomic Pathogen Detection and Monitoring
Kalantar, K. L.; Carvalho, T.; de Bourcy, C. F. A.; Dimitrov, B.; Dingle, G.; Egger, R.; Han, J.; Holmes, O. B.; Juan, Y.-F.; King, R.; Kislyuk, A.; Mariano, M.; Reynoso, L. V.; Rissato Cruz, D.; Sheu, J.; Tang, J.; Wang, J.; Zhang, M. A.; Zhong, E.; Ahyong, V.; Lay, S.; Chea, S.; Bohl, J. A.; Manning, J. E.; Tato, C. M.; DeRisi, J. L.
10.1101/2020.04.07.030551 — bioinformatics — Posted on 2020-04-18
2217 Salience network atrophy links neuron type-specific degeneration to loss of empathy in frontotemporal dementia
Pasquini, L.; Nana, A.; Toller, G.; Brown, J.; Deng, J.; Staffaroni, A.; Kim, E.-J.; Hwang, J.-H.; Li, L.; Park, Y.; Gaus, S.; Allen, I.; Sturm, V.; Spina, S.; Grinberg, L.; Rankin, K.; Kramer, J.; Rosen, H.; Miller, B.; Seeley, W.
10.1101/691212 — neuroscience — Posted on 2020-04-18
2218 Three-Compartment Model of CAR T-cell Immunotherapy
Rodrigues, B. J.; Barros, L. R. C.; Almeida, R. C.
10.1101/779793 — immunology — Posted on 2020-04-18
2223 Development and validation of a real-time RT-PCR test for screening pepper and tomato seed lots for the presence of pospiviroids
Botermans, M.; Roenhorst, J. W.; Westenberg, M.; Hooftman, M.; Jodlowska, A.; Koenraadt, H.; Verhoeven, J. T. J.; Metz, E.; van Veen, E. J.; Geraats, B. P. J.; Kemper, M.; Beugelsdijk, D. C. M.
10.1101/2020.04.17.046508 — pathology — Posted on 2020-04-17
2224 Higher vascularity at infiltrated peripheral edema differentiates proneural glioblastoma subtype
Chelebian, E.; Fuster-Garcia, E.; Alvarez-Torres, M. d. M.; Juan-Albarracin, J.; Garcia-Gomez, J. M.
10.1101/2020.04.17.046466 — neuroscience — Posted on 2020-04-17
2226 Lipopolysaccharide administration alters extracellular vesicles in human lung-cancer cells and mice
Jones, L. B.; Kumar, S.; Bell, C. R.; Crenshaw, B. J.; Coats, M. T.; Sims, B.; matthews, q. l.
10.1101/2020.04.17.046367 — microbiology — Posted on 2020-04-17
2228 Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication
Puhach, O.; Ostermann, E.; Krisp, C.; Frascaroli, G.; Schlüter, H.; Brinkmann, M. M.; Brune, W.
10.1101/2020.04.17.046516 — microbiology — Posted on 2020-04-17
2229 A Zinc-dependent metalloproteinase in the intracellular adaptation of Brucella abortus in macrophages
Gomez, L. A.; Alvarez, F. I.; Molina, R.; Soto, R.; Daza-Castro, C.; Flores, M.; Leon, Y.; Onate, A.
10.1101/2020.04.17.046490 — microbiology — Posted on 2020-04-17
2230 Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines
Grenga, L.; Gallais, F.; Pible, O.; Gaillard, J.-C.; Gouveia, D.; Batina, H.; Bazaline, N.; Ruat, S.; Culotta, K.; Miotello, G.; Debroas, S.; Roncato, M.-A.; Steinmetz, G.; Foissard, C.; Desplan, A.; Alpha-Bazin, B.; Almunia, C.; Gas, F.; Bellanger, L.; Armengaud, J.
10.1101/2020.04.17.046193 — microbiology — Posted on 2020-04-17
2231 A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals
Riva, L.; Yuan, S.; Yin, X.; Martin-Sancho, L.; Matsunaga, N.; Burgstaller, S.; Pache, L.; De Jesus, P.; Hull, M. V.; Chang, M.; Chan, J. F. W.; Cao, J.; Kwok-Man Poon, V.; Herbert, K.; Nguyen, T.-T.; Pu, Y.; Nguyen, C.; Rubanov, A.; Martinez-Sobrido, L.; Lui, W.-C.; Miorin, L.; White, K.; Johnson, J. R.; Benner, C.; Sun, R.; Schultz, P.; Su, A. I.; Garcia-Sastre, A.; Chatterjee, A.; Yuen, K.-Y.; Chanda, S.
10.1101/2020.04.16.044016 — microbiology — Posted on 2020-04-17
2232 SARS-CoV-2 is transmitted via contact and via the air between ferrets.
Richard, M.; Kok, A.; de Meulder, D.; Bestebroer, T. M.; Lamers, M. M.; Okba, N. M. A.; Fentener van Vlissingen, M.; Rockx, B.; Haagmans, B. L.; Koopmans, M. P. G.; Fouchier, R. A. M.; Herfst, S.
10.1101/2020.04.16.044503 — microbiology — Posted on 2020-04-17
2233 Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cells
Han, G.; Sinjab, A.; Treekitkarnmongkol, W.; Brennan, P.; Hara, K.; Chang, K.; Bogatenkova, E.; Sanchez-Espiridion, B.; Behrens, C.; Gao, B.; Girard, L.; Zhang, J.; Sepesi, B.; Cascone, T.; Byers, L.; Gibbons, D. L.; Chen, J.; Moghaddam, S. J.; Ostrin, E. J.; Fujimoto, J.; Shay, J.; Heymach, J. V.; Minna, J. D.; Dubinett, S.; Scheet, P. A.; Wistuba, I. I.; Hill, E.; Telesco, S.; Stevenson, C.; Spira, A. E.; Wang, L.; Kadara, H.
10.1101/2020.04.16.045617 — genomics — Posted on 2020-04-17
2241 SRF is a non-histone methylation target of KDM2B and SET7 in the regulation of myogenesis
Kook, H.; Joung, H.; Kang, J.-Y.; Kim, J.-Y.; Kwon, D.-H.; Jeong, A.; Min, H.; Shin, S.; Lee, Y.-G.; Kim, Y.-K.; Seo, S.-B.
10.1101/2020.04.17.046342 — developmental biology — Posted on 2020-04-17
2242 IGF-1 facilitates extinction of conditioned fear
Noriega-Prieto, J. A.; Maglio, L. E.; Maroto, I. B.; Martin-Cortecero, J.; Munoz-Callejas, A.; Callejo-Mostoles, M.; Fernandez de Sevilla, D.
10.1101/2020.04.15.042788 — neuroscience — Posted on 2020-04-17
2243 BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes
Padmanabhan, A.; Alexanian, M.; Linares-Saldana, R.; Gonzalez-Teran, B.; Andreoletti, G.; Huang, Y.; Connolly, A. J.; Kim, W.; Hsu, A.; Duan, Q.; Winchester, S.; Haldar, S. M.; Jain, R.; Srivastava, D.
10.1101/2020.04.16.041806 — molecular biology — Posted on 2020-04-17
2245 Toward a single dose cure for Buruli ulcer
Thomas, S.; Kalia, N. P.; Ruf, M.-T.; Pluschke, G.; Pethe, K.
10.1101/2020.04.15.044115 — microbiology — Posted on 2020-04-17
2246 Spt5 phosphorylation and the Rtf1 Plus3 domain promote Rtf1 function through distinct mechanisms
Chen, J. J.; Mbogning, J.; Hancock, M.; Majdpour, D.; Madhok, M.; Nassour, H.; Dallagnol, J. C.; Page, V.; Chatenet, D.; Tanny, J. C.
10.1101/2020.04.15.044131 — molecular biology — Posted on 2020-04-17
2247 Genetic Architecture of Maize Rind Strength Revealed by the Analysis of Divergently Selected Populations
Kumar, R.; Gyawali, A.; Morrison, G. D.; Saski, C. A.; Robertson, D. J.; Tharayil, N.; Schafer, R. J.; Beissinger, T. M.; Sekhon, R. S.
10.1101/2020.04.14.041517 — genetics — Posted on 2020-04-17
2248 Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms
Macedonia, M. C.; Drewes, J. L.; Markham, N. O.; Simmons, A. J.; Roland, J. T.; Vega, P. N.; Scurrah, C. R.; Coffey, R. J.; Shrubsole, M. J.; Sears, C. L.; Lau, K. S.
10.1101/2020.04.15.030874 — cell biology — Posted on 2020-04-17
2249 Stability of the vaginal microbiota during pregnancy and its importance for early infant colonization
Mortensen, M. S.; Rasmussen, M. A.; Stokholm, J.; Brejnrod, A. D.; Balle, C.; Thorsen, J.; Krogfelt, K. A.; Bisgaard, H.; Sorensen, S. J.
10.1101/2020.04.16.044255 — bioinformatics — Posted on 2020-04-17
2251 Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
Haupt, L.; Maus, A.; Tiburcy, M.; Koehne, S.; Maurer, W.; Tappu, R.; Haas, J.; Li, Y.; Sasse, A.; Santos, C.; Dressel, R.; Wojnowski, L.; Bunt, G.; Shah, A. M.; Meder, B.; Sossalla, S.; Wollnik, B.; Hasenfuss, G.; Streckfuss-Bömeke, K.
10.1101/2020.04.15.042424 — cell biology — Posted on 2020-04-17
2252 Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy
Hinman, M. N.; Richardson, J. I.; Sockol, R. A.; Aronson, E. D.; Stednitz, S. J.; Murray, K. N.; Berglund, J. A.; Guillemin, K.
10.1101/665380 — molecular biology — Posted on 2020-04-17
2255 Evolution of regulatory networks associated with traits under selection in cichlids
Mehta, T. K.; Koch, C.; Nash, W.; Knaack, S. A.; Sudhakar, P.; Olbei, M.; Bastkowski, S.; Penso-Dolfin, L.; Korcsmaros, T.; Haerty, W.; Roy, S.; Di-Palma, F.
10.1101/496034 — evolutionary biology — Posted on 2020-04-17
2256 Forest production efficiency increases with growth temperature
Collalti, A.; Ibrom, A.; Stockmarr, A.; Cescatti, A.; Alkama, R.; Fernandez-Martinez, M.; Matteucci, G.; Sitch, S.; Friedlingstein, P.; Ciais, P.; Goll, D. S.; Nabel, J. E. M. S.; Pongratz, J.; Arneth, A.; Haverd, V.; Prentice, I. C.
10.1101/2020.04.15.042275 — plant biology — Posted on 2020-04-17
2257 Stability of β-lactam antibiotics in bacterial growth media
Brouwers, R.; Vass, H.; Dawson, A.; Squires, T.; Tavaddod, S.; Allen, R. J.
10.1101/2020.04.15.044123 — pharmacology and toxicology — Posted on 2020-04-17
2259 Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults
Cao, Y.; Guo, Z.; Vangala, P.; Donnard, E.; Liu, P.; McDonel, P.; Ordovas-Montanes, J.; Shalek, A. K.; Finberg, R. W.; Wang, J. P.; Garber, M.
10.1101/2020.04.15.042978 — genomics — Posted on 2020-04-17
2260 Prostacyclin promotes degenerative pathology in a model of Alzheimer's disease
Womack, T.; Vollert, C.; Nwoko, O.; Schmitt, M.; Montazari, S.; Beckett, T.; Mayerich, D.; Murphy, M. P.; Eriksen, J. L.
10.1101/2020.04.15.039842 — neuroscience — Posted on 2020-04-17
2264 A facile method of mapping neutralizing HIV-1 epitopes
Datta, R.; Roy Chowdhury, R.; Manjunath, K.; Hanna, L. E.; Varadarajan, R.
10.1101/2020.04.15.041996 — molecular biology — Posted on 2020-04-17
2265 Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease
Pagoni, P.; Dardani, C.; Leppert, B.; Korologou-Linden, R.; Davey Smith, G.; Howe, L. D.; Anderson, E. L.; Stergiakouli, E.
10.1101/2020.04.15.043380 — genetics — Posted on 2020-04-17
2267 Mixing and matching methylotrophic enzymes to design a novel methanol utilization pathway in E. coli
De Simone, A.; Vicente, C. M.; Peiro, C.; Gales, L.; Bellvert, F.; Enjalbert, B.; HEUX, S.
10.1101/2020.04.15.042333 — synthetic biology — Posted on 2020-04-17
2270 Uneven distribution of Purkinje cell injury in the cerebellar vermis of term neonates with hypoxic-ischemic encephalopathy
Annink, K. V.; van Leeuwen, I. C. E.; van der Aa, N. E.; Alderliesten, T.; Groenendaal, F.; Jellema, R. K.; Nijboer, C. H. A.; Nikkels, P. G. J.; Lammens, M.; Benders, M. J. N. L.; Hoebeek, F. E.; Dudink, J.
10.1101/2020.04.15.043018 — neuroscience — Posted on 2020-04-17
2271 TOWARD A CONNECTIVITY GRADIENT-BASED FRAMEWORK FOR REPRODUCIBLE BIOMARKER DISCOVERY
Hong, S.-J.; Xu, T.; Nikolaidis, A.; Smallwood, J.; Margulies, D. S.; Bernhardt, B.; Vogelstein, J.; Milham, M.
10.1101/2020.04.15.043315 — neuroscience — Posted on 2020-04-17
2272 Deciphering cellular transcriptional alterations in Alzheimer's disease brains
Wang, X.; Mariet, A.; Li, S.; Quicksall, Z. S.; Patel, T. A.; Carnwath, T. P.; Reddy, J. S.; Carrasquillo, M. M.; Lincoln, S. J.; Nguyen, T. T.; Malphrus, K. G.; Dickson, D. W.; Crook, J. E.; Asmann, Y. W.; Ertekin-Taner, N.
10.1101/2020.04.15.041376 — neuroscience — Posted on 2020-04-17
2273 Computational synthesis of cortical dendritic morphologies
Kanari, L.; Dictus, H. T.; Chalimourda, A.; Van Geit, W.; Coste, B.; Shillcock, J. C.; Hess, K.; Markram, H.
10.1101/2020.04.15.040410 — neuroscience — Posted on 2020-04-17
2274 Iceberg or cut off - how adults who stutter articulate fluent-sounding utterances
Leha, A.; Dickhut, S.; Primassin, A.; Korzeczek, A.; Joseph, A. A.; Paulus, W.; Frahm, J.; Sommer, M.
10.1101/2020.04.15.042432 — neuroscience — Posted on 2020-04-17
2275 Blood RNA Profiles are Diagnostic for Severity in Human Acute Spinal Cord Injury
Kyritsis, N.; Torres-Espin, A.; Schupp, P. G.; Huie, J. R.; Chou, A.; Duong Fernandez, X.; Thomas, L. H.; Tsolinas, R. E.; Hemmerle, D.; Pascual, L. U.; Singh, V.; Pan, J. Z.; Talbott, J. F.; Whetstone, W. D.; Burke, J. F.; DiGiorgio, A. M.; Weinstein, P. R.; Manley, G. T.; Dhall, S. S.; Ferguson, A. R.; Oldham, M. C.; Bresnahan, J. C.; Beattie, M. S.
10.1101/2020.04.15.037325 — neuroscience — Posted on 2020-04-17
2276 Recycling old drugs: cardiac glycosides as therapeutics to target barrier inflammation of the vasculature, meninges and choroid plexus
Jansson, D.; Dieriks, V.; Rustenhoven, J.; Smyth, L.; Scotter, E.; Aalderink, M.; Feng, S.; Johnson, R.; Schweder, P.; Mee, E.; Heppner, P.; Turner, C.; Curtis, M.; Faull, R.; Dragunow, M.
10.1101/2020.04.15.043588 — neuroscience — Posted on 2020-04-17
2277 Incremental language comprehension difficulty predicts activity in the language network but not the multiple demand network
Wehbe, L.; Blank, I. A.; Shain, C.; Futrell, R.; Levy, R.; von der Malsburg, T.; Smith, N.; Gibson, E.; Fedorenko, E.
10.1101/2020.04.15.043844 — neuroscience — Posted on 2020-04-17
2280 High content live profiling reveals concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis.
Pal, A.; Kretner, B.; Abo-Rady, M.; Glass, H.; Naumann, M.; Japtok, J.; Kreiter, N.; Boeckers, T. M.; Sterneckert, J.; Hermann, A.
10.1101/2020.04.15.040394 — neuroscience — Posted on 2020-04-17
2283 scSTATseq: Diminishing Technical Dropout Enables Core Transcriptome Recovery and Comprehensive Single-cell Trajectory Mapping
Zheng, Z.; Tang, X.; Qiu, X.; Xu, H.; Wu, H.; Yu, H.; Wen, X.; Peng, Z.; Xu, F.; Zhou, Y.; Ni, Q.; Zhou, J.; Zou, L.; Chen, G.; Wan, Y.
10.1101/2020.04.15.042408 — genomics — Posted on 2020-04-17
2285 Cancer SIGVAR: A semi-automated interpretation tool for germline variants of hereditary cancer-related genes
Li, H.; Liu, S.; Wang, S.; Zeng, Q.; Chen, Y.; Fang, T.; Zhang, Y.; Zhou, Y.; Zhang, Y.; Wang, K.; Yan, Z.; Qiang, C.; Xu, M.; Chai, X.; Yuan, Y.; Huang, M.; Zhang, H.; Xiong, Y.
10.1101/2020.04.15.042283 — genetics — Posted on 2020-04-17
2287 The role of gene expression on human sexual dimorphism: too early to call
Porcu, E.; Claringbould, A.; Lepik, K.; BIOS Consortium, ; Richardson, T. G.; Santoni, F. A.; Franke, L.; Reymond, A.; Kutalik, Z.
10.1101/2020.04.15.042986 — genetics — Posted on 2020-04-17
2289 Volatiles defenses of Amazon Azteca ants (repellent ants)
Jardine, K. J.; Piva, L. R. d. O.; Rodrigues, T. B.; Spanner, G. C.; Rodrigues, J. R.; Menezes, V. S.; Sampaio, I.; Oliveira, D. C.; Gimenez, B. O.; Higuchi, N.; Chambers, J. Q.
10.1101/2020.04.15.043547 — plant biology — Posted on 2020-04-17
2293 Auditory features modelling demonstrates sound envelope representation in striate cortex
Martinelli, A.; Handjaras, G.; Betta, M.; Leo, A.; Cecchetti, L.; Pietrini, P.; Ricciardi, E.; Bottari, D.
10.1101/2020.04.15.043174 — neuroscience — Posted on 2020-04-17
2302 Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization
Pierce, B.; Keck, Z.-y.; Wang, R.; Lau, P.; Garagusi, K. J.; Elkholy, K.; Toth, E. A.; Urbanowicz, R. A.; Guest, J. D.; Agnihotri, P.; Kerzic, M. C.; Marin, A.; Andrianov, A. K.; Ball, J. K.; Mariuzza, R.; Fuerst, T. R.; Foung, S.
10.1101/2020.04.15.044073 — microbiology — Posted on 2020-04-17
2304 Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci
Hong, T.; Donmez, O.; Miller, D.; Forney, C.; Lape, M.; Parameswaran, S.; Saint Just Ribeiro, M.; Liang, J.; Magnusen, A.; Miller, W.; Chepelev, I.; Harley, J. B.; Zhao, B.; Kottyan, L. C.; Weirauch, M. T.
10.1101/2020.04.15.043612 — genomics — Posted on 2020-04-17
2305 Analysis of SARS-CoV-2 Antibodies in COVID-19 Convalescent Plasma using a Coronavirus Antigen Microarray
de Assis, R. R.; Jain, A.; Nakajima, R.; Jasinskas, A.; Felgner, J.; Obiero, J. M.; Adenaiye, O. O.; Tai, S.; Hong, F. H.; Norris, P.; Stone, M.; Simmons, G.; Bagri, A.; Schreiber, M.; Buser, A.; Holbro, A.; Battegay, M.; Milton, D. K.; Prometheus Study Group, ; Davies, H.; Corash, L. M.; Busch, M. P.; Felgner, P. L.; Khan, S.
10.1101/2020.04.15.043364 — immunology — Posted on 2020-04-17
2309 Multiscale three-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
Li, G.; Fox, S. E.; Summa, B.; Hu, B.; Wenk, C.; Akmatbekov, A.; Harbert, J. L.; Vander Heide, R. S.; Brown, J. Q.
10.1101/2020.04.11.037473 — pathology — Posted on 2020-04-17
2310 Mapping the human praxis network: an investigation of white matter disconnection in limb apraxia
Rosenzopf, H.; Wiesen, D.; Basilakos, A.; Yourganov, G.; Bonilha, L.; Rorden, C.; Fridriksson, J.; Karnath, H.-O.; Sperber, C.
10.1101/2020.04.14.041442 — neuroscience — Posted on 2020-04-17
2312 A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities
Sridhar, S.; Forrest, S.; Kean, I.; Young, J.; Bartholdson Scott, J.; Maes, M.; Pereira-Dias, J.; Parmar, S.; Routledge, M.; Rivett, L.; Dougan, G.; Weekes, M.; Curran, M.; Goodfellow, I. G.; Baker, S.
10.1101/2020.04.14.041319 — molecular biology — Posted on 2020-04-17
2313 Uncovering the core microbiome and distributions of palmerolide in Synoicum adareanum across the Anvers Island archipelago, Antarctica
Murray, A. E.; Avalon, N. E.; Bishop, L.; Davenport, K. W.; Delage, E.; Dichosa, A. E. K.; Eveillard, D.; Higham, M. L.; Kokkaliari, S.; Lo, C.-C.; Riesenfeld, C. S.; Young, R. M.; Chain, P. S. G.; Baker, B. J.
10.1101/2020.02.20.958975 — microbiology — Posted on 2020-04-17
2314 Virulence potential of a multidrug-resistant Escherichia coli strain belonging to the emerging clonal group ST101-B1 isolated from bloodstream infection
Gheller, A. C. d. M. S.; Silva, R. M.; Valiatti, T. B.; Santos, F. F.; Santos-Neto, J. F.; Cayo, R.; Streling, A. P.; Nodari, C. S.; Gales, A. C.; Nishiyama-Junior, M. Y.; Carvalho, E.; Gomes, T. A. T.
10.1101/797928 — microbiology — Posted on 2020-04-17
2315 Gut Mycobiome Dysbiosis Is Linked to Hypertriglyceridemia among Home Dwelling Elderly Danes
AHMAD, H. F.; Castro Mejia, J. L.; Krych, L.; Khakimov, B.; Kot, W.; Bechshoft, R. L.; Reitelseder, S.; Hojfeldt, G. W.; Engelsen, S. B.; Holm, L.; Faust, K.; Nielsen, D. S.
10.1101/2020.04.16.044693 — microbiology — Posted on 2020-04-17
2316 Genetic Association Study of Childhood Aggression across raters, instruments and age
Ip, H. F.; van der Laan, C. M.; Krapohl, E. M. L.; Brikell, I.; Sanchez-Mora, C.; Nolte, I. M.; St Pourcain, B.; Bolhuis, K.; Palviainen, T.; Zafarmand, H.; Colodro-Conde, L.; Gordon, S.; Zayats, T.; Aliev, F.; Jiang, C.; Wang, C. A.; Saunders, G.; Karhunen, V.; Hammerschlag, A. R.; Adkins, D. E.; Border, R.; Peterson, R. E.; Prinz, J. A.; Thiering, E.; Seppälä, I.; Vilor-Tejedor, N.; Ahluwalia, T. S.; Day, F. R.; Hottenga, J.-J.; Allegrini, A. G.; Rimfeld, K.; Chen, Q.; Lu, Y.; Martin, J.; Soler Artigas, M.; Rovira, P.; Bosch, R.; Espanol, G.; Ramos Quiroga, J. A.; Neumann, A.; Ensink, J.;
10.1101/854927 — genomics — Posted on 2020-04-16
2317 Candida albicans exhibits distinct cytoprotective responses to anti-fungal drugs that facilitate the evolution of drug resistance
Bettauer, V.; Massahi, S.; Khurdia, S.; Costa, A.; Omran, R.; Khosravi, N.; Simpson, S.; Harb, M.; Dumeaux, V.; Whiteway, M.; Hallett, M.
10.1101/2020.01.21.914549 — genomics — Posted on 2020-04-17
2319 Evaluating the informativeness of deep learning annotations for human complex diseases
Dey, K. K.; van de Geijn, B. K.; Kim, S. S.; Hormozdiari, F.; Kelley, D. R.; Price, A.
10.1101/784439 — genetics — Posted on 2020-04-17
2320 The deubiquitylase USP9X controls ribosomal stalling
Clancy, A.; Heride, C.; Pinto-Fernandez, A.; Kallinos, A.; Kayser-Bricker, K.; Wang, W.; Smith, V.; Elcocks, H.; Davis, S.; Fessler, S.; McKinnon, C.; Katz, M.; Hammonds, T.; Jones, N. P.; O'Connell, J.; Follows, B.; Mischke, S.; Caravella, J. A.; Ioannidis, S.; Dinsmore, C.; Kim, S.; Behrens, A.; Komander, D.; Kessler, B. M.; Urbe, S.; Clague, M. J.
10.1101/2020.04.15.042291 — cell biology — Posted on 2020-04-17
2321 Network-based instantaneous recording and video-rate reconstruction of 4D biological dynamics
Wang, Z.; Zhang, H.; Zhu, L.; Li, G.; Li, Y.; Yang, Y.; Ding, Y.; Gao, S.; Hsiai, T. K.; Fei, P.
10.1101/432807 — biophysics — Posted on 2020-04-17
2323 MYB5a/NEGAN activates petal anthocyanin pigmentation and shapes the MBW regulatory network in Mimulus luteusvar. variegatus
Zheng, X.; Om, K.; Stanton, K. A.; Thomas, D.; Cheng, P. A.; Eggert, A.; Yuan, Y.-W.; Puzey, J. R.; Cooley, A. M.
10.1101/2020.04.09.030536 — genetics — Posted on 2020-04-16
2326 Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis
Wu, J.; Song, D.; Li, Z.; Guo, B.; Xiao, Y.; Liu, W.; Liang, L.; Feng, C.; Gao, T.; Wang, Z.; Wen, J.; Yang, S.; Liu, P.; Wang, L.; Wang, Y.; Peng, L.; Feng, G.; Huang, S.; Stacey, G. N.; Li, W.; Huo, Y.; Jin, R.; Zhou, Q.; Wang, L.; Hu, B.; Dai, H.; Hao, J.
10.1101/2020.04.15.042119 — cell biology — Posted on 2020-04-17
2328 Three-dimensional total-internal reflection fluorescence nanoscopy with nanometric axial resolution by photometric localization of single molecules
Szalai, A. M.; Siarry, B.; Lukin, J.; Williamson, D. J.; Unsain, N.; Refojo, D.; Caceres, A.; Pilo-Pais, M.; Acuna, G.; Owen, D. M.; Simoncelli, S.; Stefani, F. D.
10.1101/693994 — biophysics — Posted on 2020-04-17
2331 Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues
Kastan, N.; Gnedeva, K.; Alisch, T.; Petelski, A.; Huggins, D.; Chiaravalli, J.; Aharanov, A.; Shakked, A.; Tzahor, E.; Nagiel, A.; Segil, N.; Hudspeth, A. J.
10.1101/2020.02.11.944157 — developmental biology — Posted on 2020-04-16
2332 Persistence as an optimal hedging strategy for bacteria in volatile environments
Browning, A. P.; Sharp, J. A.; Mapder, T.; Baker, C. M.; Burrage, K.; Simpson, M. J.
10.1101/2019.12.19.883645 — systems biology — Posted on 2020-04-16
2333 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity
Ruan, Q. T.; Yazdani, N.; Reed, E. R.; Beierle, J. A.; Peterson, L. P.; Luttik, K. P.; Szumlinski, K. K.; Johnson, W. E.; Ash, P. E. A.; Wolozin, B.; Bryant, C. D.
10.1101/2020.01.11.902908 — neuroscience — Posted on 2020-04-16
2337 Calcium Sensors ALG-2 And Peflin Bind ER Exit Sites In Alternate States To Modulate Secretion In Response To Calcium Signaling
Sargeant, J.; Costain, T.; Madreiter-Sokolowski, C. T.; Gordon, D. E.; Peden, A. A.; Malli, R.; Graier, W. F.; Hay, J. C.
10.1101/2020.02.22.944264 — cell biology — Posted on 2020-04-16
2338 LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling
Tang, R.; Wang, Y.-C.; Mei, X.; Shi, N.; Sun, C.; Ran, R.; Zhang, G.; Li, W.; Staveley-O'Carroll, K.; Li, G.; Chen, S.-Y.
10.1101/2020.02.01.930412 — molecular biology — Posted on 2020-04-16
2343 Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression
Di Domenico, A.; Pipinikas, C. P.; Maire, R. S.; Bräutigam, K.; Simillion, C.; Dettmer, M. S.; Vassella, E.; Thirlwell, C.; Perren, A.; Marinoni, I.
10.1101/2020.04.08.029785 — cancer biology — Posted on 2020-04-16
2344 Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
Weiss, T.; Taschner-Mandl, S.; Bileck, A.; Rifatbegovic, F.; Sorger, H.; Kauer, M.; Frech, C.; Windhager, R.; Gerner, C.; Ambros, P. F.; Ambros, I. M.
10.1101/2020.04.01.019422 — cancer biology — Posted on 2020-04-16
2347 Phase-amplitude markers of synchrony and noise: A resting-state and TMS-EEG study of schizophrenia
Freche, D.; Naim-Feil, J.; Hess, S.; Peled, A.; Grinshpoon, A.; Moses, E.; Levit-Binnun, N.
10.1101/740621 — neuroscience — Posted on 2020-04-16
2351 The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa
Poh, W.-H.; Lin, J.; Colley, B.; Müller, N.; Goh, B. C.; Schleheck, D.; El Sahili, A.; Marquardt, A.; Liang, Y.; Kjelleberg, S.; Lescar, J.; Rice, S. A.; Klebensberger, J.
10.1101/674879 — microbiology — Posted on 2020-04-16
2352 Y-chromosome haplotypes are associated with variation in size and age at maturity in male Chinook salmon
McKinney, G. J.; Seeb, J. E.; Pascal, C. E.; Schindler, D. E.; Gilk-Baumer, S. E.; Seeb, L. W.
10.1101/691063 — evolutionary biology — Posted on 2020-04-16
2353 Cross-scale dynamics and the evolutionary emergence of infectious diseases
Schreiber, S. J.; Ke, R.; Loverdo, C.; Park, M.; Ahsan, P.; Lloyd-Smith, J. O.
10.1101/066688 — epidemiology — Posted on 2020-04-16
2355 Pitching single focus confocal data analysis one photon at a time with Bayesian nonparametrics
Tavakoli, M.; Jazani, S.; Sgouralis, I.; Shafraz, O. M.; Donaphon, B.; Sivasankar, S.; Levitus, M.; Presse, S.
10.1101/749739 — biophysics — Posted on 2020-04-16
2356 Variant calling for cpn60 barcode sequence-based microbiome profiling
Vancuren, S. J.; Dos Santos, S. J.; Hill, J. E.; Maternal Microbiome Legacy Project Team,
10.1101/749267 — bioinformatics — Posted on 2020-04-16
2357 A solution to the learning dilemma for recurrent networks of spiking neurons
Bellec, G.; Scherr, F.; Subramoney, A.; Hajek, E.; Salaj, D.; Legenstein, R.; Maass, W.
10.1101/738385 — neuroscience — Posted on 2020-04-16
2358 In-field bioreactors demonstrate dynamic shifts in microbial communities in response to geochemical perturbations.
Wilpiszeski, R. L.; Gionfriddo, C. M.; Wymore, A. M.; Moon, J.-W.; Lowe, K. A.; Podar, M. L.; Rafie, S.; Fields, M. W.; Hazen, T. C.; Ge, X.; Poole, F.; Adams, M. W. W.; Chakraborty, R.; Fan, Y.; Van Nostrand, J. D.; Arkin, A. P.; Zhou, J.; Elias, D. A.
10.1101/2020.04.16.044594 — microbiology — Posted on 2020-04-16
2362 Stability of extemporaneously compounded amiloride nasal spray
Yellepeddi, V. K.; Sayre, C.; Burrows, A.; Watt, K. K.; Strauss, J.; Davies, S.; Battaglia, M.
10.1101/2020.04.16.044586 — pharmacology and toxicology — Posted on 2020-04-16
2365 Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock
Raymond, B.; Yengo, L.; Costilla, R.; Schrooten, C.; Bouwman, A. C.; Hayes, B. J.; Veerkamp, R. F.; Visscher, P. M.
10.1101/2020.04.16.044685 — genetics — Posted on 2020-04-16
2366 The relic ecosystem of Gymnosporia senegalensis (Lam.) Loes. in an agricultural plastic sea: past, present and future scenarios
Mendoza-Fernandez, A. J.; Martinez-Hernandez, F.; Salmeron-Sanchez, E.; Perez-Garcia, F. J.; Teruel, B.; Merlo, E.; Mota, J.
10.1101/2020.04.16.044651 — ecology — Posted on 2020-04-16
2367 A Mathematical Model of Exploration and Exploitation in Natural Scene Viewing
Malem-Shinitski, N.; Opper, M.; Reich, S.; Schwetlick, L.; Seelig, S. A.; Engbert, R.
10.1101/2020.04.16.044677 — neuroscience — Posted on 2020-04-16
2372 Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution
Kumar, R.; Verma, H.; Singhvi, N.; Sood, U.; Gupta, V.; Singh, M.; Sharma, R.; Hira, P.; Nagar, S.; Talwar, C.; Nayyar, N.; Anand, S.; Rawat, C. D.; Verma, M.; Negi, R. K.; Singh, Y.; Lal, R.
10.1101/2020.03.25.006213 — microbiology — Posted on 2020-04-16
2378 Exploring systematic biases, rooting methods and morphological evidence to unravel the evolutionary history of the genus Ficus (Moraceae)
Rasplus, J.-Y.; Rodriguez, L. J.; Saune, L.; Peng, Y.-Q.; Bain, A.; Kjellberg, F.; Harrison, R. D.; Pereira, R. A. S.; Ubaidillah, R.; Tollon-Cordet, C.; Gautier, M.; Rossi, J.-P.; cruaud, a.
10.1101/2020.04.15.042259 — evolutionary biology — Posted on 2020-04-16
2380 Genetic variation reveals individual-level climate tracking across the full annual cycle of a migratory bird
Bay, R. A.; Karp, D. S.; Saracco, J. F.; Anderegg, W. R.; Frishkoff, L.; Wiedenfeld, D.; Smith, T. B.; Ruegg, K.
10.1101/2020.04.15.043331 — evolutionary biology — Posted on 2020-04-16
2384 Varietas delectat: groups with diverse personalities mitigate physiological stress in a songbird
Vagasi, C. I.; Fulop, A.; Osvath, G.; Pap, P. L.; Penzes, J.; Benko, Z.; Lendvai, A. Z.; Barta, Z.
10.1101/2020.04.15.043471 — ecology — Posted on 2020-04-16
2385 Areas of global importance for terrestrial biodiversity, carbon, and water
Jung, M.; Arnell, A.; De Lamo, X.; Garcia-Rangel, S.; Lewis, M.; Mark, J.; Merow, C.; Miles, L.; Ondo, I.; Pironon, S.; Ravilious, C.; Rivers, M.; Schepashenko, D.; Tallowin, O.; van Soesbergen, A.; Govaerts, R.; Boyle, B. L.; Enquist, B. J.; Feng, X.; Gallagher, R. V.; Maitner, B.; Meiri, S.; Mulligan, M.; Ofer, G.; Hanson, J. O.; Jetz, W.; Di Marco, M.; McGowan, J.; Rinnan, D. S.; Sachs, J. D.; Lesiv, M.; Adams, V. M.; Andrew, S. C.; Burger, J. R.; Hannah, L.; Marquet, P.; McCarthy, J. K.; Morueta-Holme, N.; Newman, E. A.; Park, D. S.; Roehrdanz, P. R.; Svenning, J.-C.; Violle, C.; Wieringa,
10.1101/2020.04.16.021444 — ecology — Posted on 2020-04-16
2387 Predicting the Viability of Beta-Lactamase: How Folding and Binding Free Energies Correlate with Beta-Lactamase Fitness
Yang, J.; Naik, N.; Patel, J. S.; Wylie, C. S.; Gu, W.; Huang, J.; Ytreberg, F. M.; Naik, M. T.; Weinreich, D. M.; Rubenstein, B. M.
10.1101/2020.04.15.043661 — biophysics — Posted on 2020-04-16
2390 Comprehensive database of secondary metabolites from cyanobacteria
Jones, M. R.; Pinto, E.; Torres, M. A.; Doerr, F.; Mazur-Marzec, H.; Szubert, K.; Tartaglione, L.; Dell'Aversano, C.; Miles, C. O.; Beach, D. G.; McCarron, P.; Sivonen, K.; Fewer, D. P.; Jokela, J.; Janssen, E. M.- L.
10.1101/2020.04.16.038703 — bioinformatics — Posted on 2020-04-16
2392 Astrocyte- and neuron-derived extracellular vesicles from Alzheimer's disease patients effect complement-mediated neurotoxicity
Nogueras-Ortiz, C. J.; Mahairaki, V.; Delgado-Peraza, F. M.; Das, D.; Avgerinos, K.; Hentschel, M.; Goetzl, E. J.; Mattson, M. P.; Kapogiannis, D.
10.1101/2020.04.14.041863 — neuroscience — Posted on 2020-04-16
2397 Primate phylogenomics uncovers multiple rapid radiations and ancient interspecific introgression
Vanderpool, D.; Minh, B. Q.; Lanfear, R.; Hughes, D.; Murali, S.; Harris, R. A.; Raveendran, M.; Muzny, D. M.; Gibbs, R. A.; Worley, K. C.; Rogers, J.; Hahn, M. W.
10.1101/2020.04.15.043786 — evolutionary biology — Posted on 2020-04-16
2398 Asian wild apples threatened by gene flow from domesticated apples and by their pestified pathogen
Feurtey, A.; Guitton, E.; De Gracia Coquerel, M.; Duvaux, L.; Shiller, J.; Bellanger, M.-N.; Expert, P.; Sannier, M.; Caffier, V.; GIRAUD, T.; Le Cam, B.; Lemaire, C.
10.1101/2020.04.15.042242 — evolutionary biology — Posted on 2020-04-16
2399 Consequences of population structure for sex allocation and sexual conflict
Rodrigues, L.; Torralba Saez, M.; Alpedrinha, J.; Lefevre, S.; Brengues, M.; Magalhaes, S.; Duncan, A.
10.1101/2020.04.16.042994 — evolutionary biology — Posted on 2020-04-16
2401 Insect herbivory on urban trees: Complementary effects of tree neighbours and predation
Stemmelen, A.; Paquette, A.; Benot, M.-L.; Kadiri, Y.; Jactel, H.; Castagneyrol, B.
10.1101/2020.04.15.042317 — ecology — Posted on 2020-04-16
2404 Spectral graph theory efficiently characterises ventilation heterogeneity in lung airway networks.
Whitfield, C. A.; Latimer, P.; Horsley, A.; Wild, J. M.; Collier, G. J.; Jensen, O. E.
10.1101/2020.04.15.042416 — biophysics — Posted on 2020-04-16
2407 Complement receptor 3 forms a compact high affinity complex with iC3b
Jensen, R. K.; Bajic, G.; Sen, M.; Springer, T.; Vorup-Jensen, T.; Andersen, G. R.
10.1101/2020.04.15.043133 — biochemistry — Posted on 2020-04-16
2408 Carbon Sequestration Potential of Oil Palm Plantations in Southern Philippines
Borbon, S. M. C.; Medina, M. A. P.; Patricio, J. H. P.; Bruno, A. G. T.
10.1101/2020.04.14.041822 — ecology — Posted on 2020-04-16
2410 Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer
Bala, P.; Singh, A. K.; Kavadipula, P.; Kotapalli, V.; Sabarinathan, R.; Bashyam, M. D.
10.1101/2020.04.15.040741 — cancer biology — Posted on 2020-04-16
2413 multicrispr: fast gRNA designer enables prime editing and parallel targeting of thousands of targets
Bhagwat, A. M.; Graumann, J.; Wiegandt, R.; Bentsen, M.; Kuenne, C.; Preussner, J.; Braun, T.; Looso, M.
10.1101/2020.04.15.042861 — bioinformatics — Posted on 2020-04-16
2415 Identifying Neural Signatures Mediating Behavioral Symptoms and Psychosis Onset: High-Dimensional Whole Brain Functional Mediation Analysis
Chén, O. Y.; Cao, H.; Phan, H.; Nagels, G.; Reinen, J. M.; Gou, J.; Qian, T.; Di, J.; Prince, J.; Cannon, T. D.; de Vos, M.
10.1101/2020.04.15.043034 — bioinformatics — Posted on 2020-04-16
2418 In situ reprogramming of gut bacteria by oral delivery
Hsu, B. B.; Plant, I. N.; Lyon, L.; Anastassacos, F. M.; Way, J. C.; Silver, P. A.
10.1101/2020.04.15.043232 — bioengineering — Posted on 2020-04-16
2419 Deep Learning Improves Macromolecules Localization and Identification in 3D Cellular Cryo-Electron Tomograms
Moebel, E.; Martinez-Sanchez, A.; Lariviere, D.; Fourmentin, E.; Ortiz, J.; Baumeister, W.; Kervrann, C.
10.1101/2020.04.15.042747 — bioinformatics — Posted on 2020-04-16
2424 Breakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase
Karandur, D.; Bhattacharyya, M.; Xia, Z.; Lee, Y. K.; Muratcioglu, S.; McAffee, D.; McSpadden, E.; Qiu, B.; Groves, J. T.; Williams, E. R.; Kuriyan, J.
10.1101/2020.04.15.043067 — bioinformatics — Posted on 2020-04-16
2425 Uncovering of Cytochrome P450 Anatomy by SecStrAnnotator
Midlik, A.; Navratilova, V.; Moturu, T. R.; Koca, J.; Svobodova, R.; Berka, K.
10.1101/2020.04.15.042531 — bioinformatics — Posted on 2020-04-16
2426 Evaluating rehabilitation progress using motion features identified by machine learning
Lu, L.; Tan, Y.; Klaic, M.; Galea, M. P.; Khan, F.; Oliver, A.; Mareels, I.; Oetomo, D.; Zhao, E.
10.1101/2020.04.15.043919 — bioengineering — Posted on 2020-04-16
2427 Tuning Hsp104 specificity to selectively detoxify alpha-synuclein
Mack, K. L.; Kim, H.; Jackrel, M. E.; Lin, J.; DeNizio, J. E.; Yan, X.; Chuang, E.; Tariq, A.; Cupo, R. R.; Castellano, L. M.; Caldwell, K. A.; Caldwell, G. A.; Shorter, J.
10.1101/2020.04.15.043935 — bioengineering — Posted on 2020-04-16
2428 Neonicotinoids Disrupt Circadian Rhythms and Sleep in Honey Bees
Tackenberg, M. C.; Giannoni-Guzman, M. A.; Doll, C. A.; Agosto-Rivera, J. L.; Broadie, K.; Moore, D.; McMahon, D. G.
10.1101/2020.04.15.042960 — animal behavior and cognition — Posted on 2020-04-16
2429 GABA AND GLUTAMATE CHANGES IN PEDIATRIC MIGRAINE
Bell, T. K.; Stokoe, M.; Khaira, A.; Webb, M.; Noel, M.; Amoozegar, F.; Harris, A.
10.1101/2020.04.14.041616 — neuroscience — Posted on 2020-04-16
2430 White matter hyperintensity-associated structural disconnection, resting state functional connectivity, and cognitive control in older adults
Jaywant, A.; Dunlop, K.; Victoria, L. W.; Oberlin, L.; Lynch, C.; Respino, M.; Kuceyeski, A.; Scult, M.; Hoptman, M.; Liston, C.; O'Dell, M. W.; Alexopoulos, G. S.; Gunning, F. M.
10.1101/2020.04.14.039065 — neuroscience — Posted on 2020-04-16
2431 A Shift from Value- to Saliency- Neural Encoding of Subjective Value in Combat Veterans with PTSD during Decision Making under Uncertainty
Jia, R.; Ruderman, L.; Gordon, C.; Ehrlich, D.; Horvath, M.; Mirchandani, S.; DeFontes, C.; Krystal, J.; Harpaz-Rotem, I.; Levy, I.
10.1101/2020.04.14.041467 — neuroscience — Posted on 2020-04-16
2437 A pharmacological interactome platform for discovery of pain mechanisms and targets
Wangzhou, A.; Paige, C.; Neerukonda, S. V.; Dussor, G.; Ray, P. R.; Price, T. J.
10.1101/2020.04.14.041715 — neuroscience — Posted on 2020-04-16
2438 Endothelial basement membrane laminins as an environmental cue in monocyte differentiation to macrophages.
Li, L.; Song, J.; Chuquisana, O.; Hannocks, M.-J.; Loismann, S.; Vogl, T.; Roth, J.; Hallmann, R.; Sorokin, L.
10.1101/2020.04.15.043190 — immunology — Posted on 2020-04-16
2439 Revisiting the interaction of heme with hemopexin: Recommendations for the responsible use of an emerging drug
Detzel, M. S.; Syllwasschy, B. F.; Steinbock, F.; Ramoji, A.; Hopp, M.-T.; Paul George, A. A.; Neugebauer, U.; Imhof, D.
10.1101/2020.04.16.044321 — biochemistry — Posted on 2020-04-16
2440 RubyACRs, non-algal anion channelrhodopsins with highly red-shifted absorption
Govorunova, E. G.; Sineshchekov, O. A.; Li, H.; Wang, Y.; Brown, L. S.; Spudich, J. L.
10.1101/2020.04.15.043158 — biochemistry — Posted on 2020-04-16
2441 On identifying the eukaryotic N-glycosylation scramblase by activity correlation profiling
Verchere, A.; Cowton, A.; Jenni, A.; Rauch, M.; Häner, R.; Graumann, J.; Bütikofer, P.; Menon, A. K.
10.1101/2020.04.15.043679 — biochemistry — Posted on 2020-04-16
2442 Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism
Norman, B. P.; Davison, A. S.; Hughes, J. H.; Sutherland, H.; Wilson, P. J.; Berry, N. G.; Hughes, A. T.; Milan, A. M.; Jarvis, J. C.; Roberts, N. B.; Ranganath, L. R.; Bou-Gharios, G.; Gallagher, J. A.
10.1101/2020.04.16.044347 — biochemistry — Posted on 2020-04-16
2444 Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Acevedo-Rocha, C. G.; Li, A.; D'Amore, L.; Hoebenreich, S.; Sanchis Martinez, J.; Lubrano, P.; Ferla, M.; Garcia Borras, M.; Osuna, S.; Reetz, M. T.
10.1101/2020.04.14.041590 — evolutionary biology — Posted on 2020-04-16
2446 Flexible open-source automation for robotic bioengineering
Chory, E. J.; Gretton, D. W.; Debenedictis, E. A.; Esvelt, K. M.
10.1101/2020.04.14.041368 — bioengineering — Posted on 2020-04-16
2448 Mapping the human praxis network: an investigation of white matter disconnection in limb apraxia
Rosenzopf, H.; Wiesen, D.; Basilakos, A.; Yourganov, G.; Bonilha, L.; Rorden, C.; Fridriksson, J.; Karnath, H.-O.; Sperber, C.
10.1101/2020.04.14.041442 — neuroscience — Posted on 2020-04-16
2451 The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa
Poh, W.-H.; Lin, J.; Colley, B.; Müller, N.; Goh, B. C.; Schleheck, D.; El Sahili, A.; Marquardt, A.; Liang, Y.; Kjelleberg, S.; Lescar, J.; Rice, S. A.; Klebensberger, J.
10.1101/674879 — microbiology — Posted on 2020-04-16
2453 Proteomics of protein trafficking by in vivo tissue-specific labeling
Droujinine, I. A.; Wang, D.; Hu, Y.; Udeshi, N. D.; Mu, L.; Svinkina, T.; Zeng, R.; Branon, T.; Tabatabai, A.; Bosch, J. A.; Asara, J. M.; Ting, A. Y.; Carr, S. A.; Perrimon, N.
10.1101/2020.04.15.039933 — physiology — Posted on 2020-04-16
2459 Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis
Wu, J.; Song, D.; Li, Z.; Guo, B.; Xiao, Y.; Liu, W.; Liang, L.; Feng, C.; Gao, T.; Wang, Z.; Wen, J.; Yang, S.; Liu, P.; Wang, L.; Wang, Y.; Peng, L.; Feng, G.; Huang, S.; Stacey, G. N.; Li, W.; Huo, Y.; Jin, R.; Zhou, Q.; Wang, L.; Hu, B.; Dai, H.; Hao, J.
10.1101/2020.04.15.042119 — cell biology — Posted on 2020-04-16
2461 Structures of metabotropic GABAB receptor
Papasergi-Scott, M. M.; Robertson, M. J.; Seven, A. B.; Panova, O.; Mathiesen, J. M.; Skiniotis, G.
10.1101/2020.04.15.004267 — neuroscience — Posted on 2020-04-16
2462 The deubiquitylase USP9X controls ribosomal stalling
Clancy, A.; Heride, C.; Pinto-Fernandez, A.; Kallinos, A.; Kayser-Bricker, K.; Wang, W.; Smith, V.; Elcocks, H.; Davis, S.; Fessler, S.; McKinnon, C.; Katz, M.; Hammonds, T.; Jones, N. P.; O'Connell, J.; Follows, B.; Mischke, S.; Caravella, J. A.; Ioannidis, S.; Dinsmore, C.; Kim, S.; Behrens, A.; Komander, D.; Kessler, B. M.; Urbe, S.; Clague, M. J.
10.1101/2020.04.15.042291 — cell biology — Posted on 2020-04-16
2464 A multivalent fuzzy interface drives reversible COPII coat assembly.
Miller, E. A.; Stancheva, V.; Hutchings, J.; Li, X.-H.; Santhanam, B.; Zanetti, G.; Babu, M. M.
10.1101/2020.04.15.043356 — cell biology — Posted on 2020-04-16
2466 TANGO1 membrane helices create a lipid diffusion barrier at curved membranes
Raote, I.; Ernst, A. M.; Campelo, F.; Rothman, J. E.; Pincet, F.; Malhotra, V.
10.1101/2020.04.15.043307 — cell biology — Posted on 2020-04-16
2467 Screening for inborn errors of metabolism using untargeted metabolomics and out-of-batch controls
Bongaerts, M.; Bonte, R.; Demirdas, S.; Jacobs, E.; Oussoren, E.; van der Ploeg, A.; Wagenmakers, M.; Hofstra, R.; Blom, H.; Reinders, M.; Ruijter, G.
10.1101/2020.04.14.040469 — bioinformatics — Posted on 2020-04-16
2468 Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex
Delmotte, Q.; Medina, I.; Hamze, M.; Buhler, E.; Zhang, J.; Belgacem, Y. H.; Porcher, C.
10.1101/799015 — neuroscience — Posted on 2020-04-16
2469 HD-tDCS over mIPS causally modulates online reach correction
Goettker, A.; Caie, B.; Jeyachandra, J.; Xu, S.; Gallivan, J.; Dmochowski, J.; Fiehler, K.; Blohm, G.
10.1101/708693 — neuroscience — Posted on 2020-04-16
2472 Evolutionary variation in MADS-box dimerization affects floral development and protein degradation dynamics in maize
Abraham-Juarez, M. J.; Schrager-Lavelle, A.; Man, J.; Whipple, C. J.; Handakumbura, P.; Babbitt, C. C.; Bartlett, M.
10.1101/2020.03.09.984260 — plant biology — Posted on 2020-04-16
2474 Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice
Muniappan, L.; Okuyama, M.; Javidan, A.; Thiagarajan, D.; Jiang, W.; Moorleghen, J. J.; Yang, L.; Balakrishnan, A.; Howatt, D.; Uchida, H. A.; Saido, T. C.; Subramanian, V.
10.1101/2020.04.15.043687 — pathology — Posted on 2020-04-15
2475 Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice.
McKendrick, G.; Garrett, H.; Jones, H.; McDevitt, D. S.; Sharma, S.; Silberman, Y.; Graziane, N. M.
10.1101/2020.01.22.915728 — neuroscience — Posted on 2020-04-15
2478 Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics
Si, L.; Bai, H.; Rodas, M.; Cao, W.; Oh, C. Y.; Jiang, A.; Nurani, A.; Zhu, D. Y.; Goyal, G.; Gilpin, S.; Prantil-Baun, R.; Ingber, D. E.
10.1101/2020.04.13.039917 — microbiology — Posted on 2020-04-15
2481 Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019
Hirose, Y.; Yamaguchi, M.; Takemoto, N.; Miyoshi-Akiyama, T.; Sumitomo, T.; Nakata, M.; Ikebe, T.; Hanada, T.; Yamaguchi, T.; Kawahara, R.; Okuno, R.; Otsuka, H.; Matsumoto, Y.; Terashima, Y.; Kazawa, Y.; Nakanishi, N.; Uchida, K.; Akiyama, Y.; Iwabuchi, K.; Nakagawa, C.; Yamamoto, K.; Kawabata, S.
10.1101/2020.04.14.042051 — microbiology — Posted on 2020-04-16
2482 VIBRIO CHOLERAE ADAPTS TO SESSILE AND MOTILE LIFESTYLES BY CYCLIC DI-GMP REGULATION OF CELL SHAPE
Fernandez, N. L.; Nhu, N. T.; Hsueh, B. Y.; Franklin, J. L.; Dufour, Y. S.; Waters, C. M.
10.1101/2020.04.15.043257 — microbiology — Posted on 2020-04-16
2483 Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula
Bechon, N.; Jimenez-Fernandez, A.; Witwinowski, J.; Bierque, E.; Taib, N.; Cokelaer, T.; Ma, L.; Ghigo, J.-M.; Gribaldo, S.; Beloin, C.
10.1101/2020.04.15.042101 — microbiology — Posted on 2020-04-16
2484 Lateral gene transfer of anion-conducting channelrhodopsins between green algae and giant viruses
Rozenberg, A.; Oppermann, J.; Wietek, J.; Fernandez Lahore, R. G.; Sandaa, R.-A.; Bratbak, G.; Hegemann, P.; Beja, O.
10.1101/2020.04.15.042127 — microbiology — Posted on 2020-04-16
2485 Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells
Augusto, L.; Martynowicz, J.; Amin, P. H.; Alakhras, N. S.; Kaplan, M.; Wek, R. C.; Sullivan, W. J.
10.1101/2020.04.14.042069 — microbiology — Posted on 2020-04-16
2486 Comprehensive genome analyses of Sellimonas intestinalis, a potential biomarker of homeostasis gut recovery
Munoz, M.; Guerrero-Araya, E.; Cortes-Tapia, C.; Plaza-Garrido, A.; Lawley, T. D.; Paredes-Sabja, D.
10.1101/2020.04.14.041921 — microbiology — Posted on 2020-04-16
2487 A DNA vaccine strategy to activate natural killer cells for therapeutic targeting of XPO1-positive tumors
Rettman, P.; Blunt, M. D.; Mbiribindi, B.; Fulton, R.; Schittenhelm, R.; Vallejo, A. F.; Bastidas-Legarda, L.; Polak, M. E.; Ayala, R.; Purcell, A. W. E.; Al-Shamkhani, A.; Retiere, C.; Khakoo, S. I.
10.1101/2020.04.15.042077 — immunology — Posted on 2020-04-15
2490 Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres
Chen, W.; Smajs, D.; Hu, Y.; Ke, W.; Pospisilova, P.; Hawley, K. L.; Caimano, M. J.; Radolf, J. D.; Sena, A. C.; Tucker, J. D.; Yang, B.; Juliano, J. J.; Zheng, H.; Parr, J. B.
10.1101/2020.04.15.043992 — genomics — Posted on 2020-04-15
2492 Non-Canonical Targets of HIF1a Drive Cell-Type-Specific Dysfunction
Allan, K. C.; Hu, L. R.; Morton, A. R.; Scavuzzo, M. A.; Gevorgyan, A. S.; Clayton, B. L. L.; Bederman, I.; Hung, S.; Bartels, C. F.; Madhavan, M.; Tesar, P. J.
10.1101/2020.04.03.003632 — developmental biology — Posted on 2020-04-16
2493 MicroRNA 1253 regulation of WAVE2 and its relevance to health disparities in hypertension
Arkorful, M. A.; Noren Hooten, N.; Zhang, Y.; Hewitt, A. N.; Barrientos Sanchez, L.; Evans, M. K.; Dluzen, D. F.
10.1101/833673 — cell biology — Posted on 2020-04-15
2494 Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster
Vigano, M. A.; Ell, C.-M.; Kustermann, M. M.; Aguilar, G.; Matsuda, S.; Zhao, N.; Stasevich, T. J.; Pyrowolakis, G.; Affolter, M.
10.1101/2020.04.06.027599 — cell biology — Posted on 2020-04-15
2495 An Endocytic Capture Model for Skeletal Muscle T-tubule Formation
Hall, T. E.; Martel, N.; Ariotti, N.; Xiong, Z.; Lo, H. P.; Ferguson, C. E.; Rae, J.; Lim, Y.-W.; Parton, R. G.
10.1101/2020.03.05.979666 — cell biology — Posted on 2020-04-15
2496 Procentriole microtubules as drivers of centriole reduplication
Vasquez-Limeta, A.; Sullenberger, C.; Kong, D.; Lukasik, K.; Shukla, A.; Loncarek, J.
10.1101/2020.04.12.038307 — cell biology — Posted on 2020-04-16
2497 Dense cellular segmentation for EM using 2D-3D neural network ensembles
Guay, M. D.; Emam, Z. A. S.; Anderson, A. B.; Aronova, M. A.; Storrie, B.; Pokrovskaya, I. D.; Leapman, R. D.
10.1101/2020.01.05.895003 — cell biology — Posted on 2020-04-16
2498 The capacity of the ovarian cancer tumor microenvironment to integrate inflammation signaling conveys a shorter disease-free interval
Jordan, K. R.; Sikora, M. J.; Slansky, J. E.; Minic, A.; Richer, J. K.; Moroney, M. R.; Costello, J. C.; Clauset, A.; Behbakht, K.; Kumar, T. R.; Bitler, B. G.
10.1101/2020.04.14.041145 — cancer biology — Posted on 2020-04-15
2500 The coordination of spindle-positioning forces during the asymmetric division of the C. elegans zygote is revealed by distinct microtubule dynamics at the cortex.
Bouvrais, H.; Chesneau, L.; Le Cunff, Y.; Fairbrass, D.; Soler, N.; Pastezeur, S.; Pecot, T.; Kervrann, C.; Pecreaux, J.
10.1101/638593 — biophysics — Posted on 2020-04-15
2504 MYB5a/NEGAN activates petal anthocyanin pigmentation and shapes the MBW regulatory network in Mimulus luteusvar. variegatus
Zheng, X.; Om, K.; Stanton, K. A.; Thomas, D.; Cheng, P. A.; Eggert, A.; Yuan, Y.-W.; Puzey, J. R.; Cooley, A. M.
10.1101/2020.04.09.030536 — genetics — Posted on 2020-04-15
2505 Immune factor of bacterial origin protects ticks against host microbial commensals
Hayes, B. M.; Radkov, A. D.; Yarza, F.; Flores, S.; Kim, J. R.; Zhao, Z.; Lexa, K. W.; Marnin, L.; Biboy, J.; Bowcutt, V.; Vollmer, W.; Pedra, J. H.; Chou, S.
10.1101/2020.04.10.036376 — evolutionary biology — Posted on 2020-04-15
2506 Rqc1 and other yeast proteins containing highly positively charged domains are not targets of the RQC complex
Barros, G. C.; Requiao, R. D.; Carneiro, R. L.; Masuda, C. A.; Moreira, M. H.; Rossetto, S.; Domitrovic, T.; Palhano, F.
10.1101/849851 — biochemistry — Posted on 2020-04-15
2509 Relevance of enriched expression of SARS-CoV-2 binding receptor ACE2 in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients
Etiologically Elusive Disorders Research Network (EEDRN), ; Kumar, A.; Faiq, M. A.; Pareek, V.; Raza, K.; Narayan, R. K.; Prasoon, P.; Kumar, P.; Kulandhasamy, M.; Kumari, C.; Kant, K.; Singh, H. N.; Qadri, R.; Pandey, S. N.; Kumar, S.
10.1101/2020.04.14.040204 — pathology — Posted on 2020-04-15
2511 Shape coding in occipito-temporal cortex relies on object silhouette, curvature and medial-axis
Papale, P.; Leo, A.; Handjaras, G.; Cecchetti, L.; Pietrini, P.; Ricciardi, E.
10.1101/814251 — neuroscience — Posted on 2020-04-15
2515 Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric Vaccine
Akhand, M. R. N.; Azim, K. F.; Hoque, S. F.; Moli, M. A.; Joy, B. D.; Akter, H.; Afif, I. K.; Ahmed, N.; Hasan, M.
10.1101/2020.04.15.036285 — immunology — Posted on 2020-04-15
2516 A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors.
Fadason, T.; Gokuladhas, S.; Golovina, E.; Ho, D.; Farrow, S.; Nyaga, D. M.; Pan, H.; Karnani, N.; Wong, C.; Cooper, A.; Schierding, W.; O'Sullivan, J. M.
10.1101/2020.04.14.042002 — genomics — Posted on 2020-04-15
2517 Opposing modulation of Cx26 gap junctions and hemichannels by CO2
Nijjar, S.; Maddison, D.; Meigh, L.; de Wolf, E.; Rodgers, T.; Cann, M. J.; Dale, N.
10.1101/584722 — cell biology — Posted on 2020-04-15
2518 Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry
Kim, S. Y.; Jin, W.; Sood, A.; Montgomery, D. W.; Grant, O. C.; Fuster, M. M.; Fu, L.; Dordick, J. S.; Woods, R. J.; Zhang, F.; Linhardt, R. J.
10.1101/2020.04.14.041459 — biochemistry — Posted on 2020-04-15
2519 The isolation of proteins on nascent DNA (iPOND) reveals a role for RIF1 in the organization of replication factories
Ribeyre, C.; Lebdy, R.; Patouillard, J.; Larroque, M.; Abou-Merhi, R.; Larroque, C.; Constantinou, A.
10.1101/669234 — cell biology — Posted on 2020-04-15
2520 Allosteric priming of E. coli CheY by the flagellar motor protein FliM
Wheatley, P.; Pandini, A.; Gupta, S.; Chen, Y.; Petzold, C. J.; Ralston, C. Y.; Blair, D. F.; Khan, S. M.
10.1101/781468 — biophysics — Posted on 2020-04-15
2522 Socio-Ecological Network Structures from Process Graphs
Lao, A.; Cabezas, H.; Orosz, A.; Friedler, F.; Tan, R.
10.1101/2020.04.15.042697 — ecology — Posted on 2020-04-15
2530 Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Williamson, B.; Feldmann, F.; Schwarz, B.; Meade-White, K.; Porter, D.; Schulz, J.; van Doremalen, N.; Leighton, I.; Yinda, C. K.; Perez-Perez, L.; Okumura, A.; Lovaglio, J.; Hanley, P.; Saturday, G.; Bosio, C.; Anzick, S.; Barbian, K.; Chilar, T.; Martens, C.; Scott, D.; Munster, V.; de Wit, E.
10.1101/2020.04.15.043166 — microbiology — Posted on 2020-04-15
2531 Multidrug treatment with nelfinavir and cepharanthine against COVID-19
Ohashi, H.; Watashi, K.; Saso, W.; Shionoya, K.; Iwanami, S.; Hirokawa, T.; Shirai, T.; Kanaya, S.; Ito, Y.; Kim, K. S.; Nishioka, K.; Ando, S.; Ejima, K.; Koizumi, Y.; Tanaka, T.; Aoki, S.; Kuramochi, K.; Suzuki, T.; Maenaka, K.; Matano, T.; Muramatsu, M.; Saijo, M.; Aihara, K.; Iwami, S.; Takeda, M.; McKeating, J.; Wakita, T.
10.1101/2020.04.14.039925 — microbiology — Posted on 2020-04-15
2532 TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
Bestle, D.; Heindl, M. R.; Limburg, H.; Van Lam van, T.; Pilgram, O.; Moulton, H.; Stein, D. A.; Hardes, K.; Eickmann, M.; Dolnik, O.; Rohde, C.; Becker, S.; Klenk, H.-D.; Garten, W.; Steinmetzer, T.; Bottcher-Friebertshauser, E.
10.1101/2020.04.15.042085 — microbiology — Posted on 2020-04-15
2533 Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Gassen, N. C.; Papies, J.; Bajaj, T.; Dethloff, F.; Emanuel, J.; Weckmann, K.; Heinz, D. E.; Heinemann, N.; Lennarz, M.; Richter, A.; Niemeyer, D.; Corman, V. M.; Giavalisco, P.; Drosten, C.; Muller, M. A.
10.1101/2020.04.15.997254 — microbiology — Posted on 2020-04-15
2534 Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability
Mestre-Fos, S.; Ito, C.; Moore, C. M.; Reddi, A. R.; Williams, L. D.
10.1101/2020.04.15.042721 — biochemistry — Posted on 2020-04-15
2542 Subtypes of functional connectivity associate robustly with ASD diagnosis
Urchs, S. G.; Tam, A.; Orban, P.; Moreau, C.; Benhajali, Y.; Nguyen, H. D.; Evans, A. C.; Bellec, P.
10.1101/2020.04.14.040576 — neuroscience — Posted on 2020-04-15
2543 Small molecule cognitive enhancer reverses age-related memory decline in mice.
Krukowski, K.; Nolan, A.; Frias, E. S.; Boone, M.; Ureta, G.; Grue, K.; Paladini, M.-S.; Elizarraras, E.; Delgado, L.; Bernales, S.; Walter, P.; Rosi, S.
10.1101/2020.04.13.039677 — neuroscience — Posted on 2020-04-15
2544 Polyphosphate Functions In Vivo as Iron Chelator and Fenton Inhibitor
Jakob, U.; Beaufay, F.; Quarles, E. K.; Franz, A.; Katamanin, O.; Wholey, W. Y.
10.1101/2020.04.14.040345 — microbiology — Posted on 2020-04-15
2545 Filovirus infection induces an anti-inflammatory state in Rousettus bats
Jayaprakash, A. D.; Ronk, A. J.; Prasad, A. N.; Covington, M. F.; Stein, K. R.; Schwarz, T. M.; Hekmaty, S.; Fenton, K. A.; Geisbert, T. W.; Basler, C. F.; Bukreyev, A.; Sachidanandam, R.
10.1101/2020.04.13.039503 — microbiology — Posted on 2020-04-15
2546 Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
Karabegovic, I.; Portilla-Fernandez, E.; Li, Y.; Ma, J.; Maas, S. C. E.; Sun, D.; Hu, E. A.; Kuhnel, B.; Zhang, Y.; Ambatipudi, S.; Fiorito, G.; Huang, J.; Castillo-Fernandez, J. E.; Wiggins, K. L.; de Klein, N.; Grioni, S.; Swenson, B. R.; Polidoro, S.; Treur, J. L.; Cuenin, C.; Tsai, P.-C.; Costeira, R.; Chajes, V.; Braun, K.; Verweij, N.; Kretschmer, A.; Franke, L.; van Meurs, J. B. J.; Uitterlinden, A. G.; de Knegt, R. J.; Ikram, M. A.; Dehghan, A.; Peters, A.; Schottker, B.; Gharib, S. A.; Sotoodehnia, N.; Bell, J. T.; Elliott, P.; Vineis, P.; Relton, C.; Herceg, Z.; Brenner, H.; Waldenbe
10.1101/2020.04.15.042267 — genomics — Posted on 2020-04-15
2548 Parasitoid community responds indiscriminately to fluctuating spruce budworm and other caterpillars on balsam fir
Greyson-Gaito, C. J.; McCann, K. S.; Fründ, J.; Lucarotti, C. J.; Smith, M. A.; Eveleigh, E. S.
10.1101/615799 — ecology — Posted on 2020-04-15
2549 Global trends in biodiversity and ecosystem services from 1900 to 2050
Pereira, H. M.; Schipper, A.; Arneth, A.; Hoskins, A. J.; Krause, A. J.; Purvis, A.; Strassburg, B.; Chaplin-Kramer, R.; Poulter, B.; Quesada, B.; Rondinini, C.; Guerra, C. A.; Ware, C.; Merow, C.; Baisero, D.; van Vuuren, D.; Di Fulvio, F.; Stehfest, E.; Wolf, F.; Hurtt, G.; Havlik, P.; Hirata, A.; Humpenoeder, F.; Kim, H.; Rosa, I. M.; Santos Martins, I.; Hilbers, J.; Janse, J.; Johnson, J. A.; Meijer, J.; Settele, J.; Takahashi, K.; Chini, L.; Leclere, D.; Obersteiner, M.; Harfoot, M. B. J.; Di Marco, M.; Talluto, M.; Titeux, N.; Ohashi, H.; Leadley, P.; Anthoni, P.; Visconti, P.; Popp, A.;
10.1101/2020.04.14.031716 — ecology — Posted on 2020-04-15
2551 Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
Hansen, J. N.; Kaiser, F.; Klausen, C.; Stueven, B.; Chong, R.; Boenigk, W.; Mick, D. U.; Moeglich, A.; Jurisch-Yaksi, N.; Schmidt, F. I.; Wachten, D.
10.1101/2020.02.04.933440 — cell biology — Posted on 2020-04-15
2552 Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis
Shyu, P.; Yap, W. S.; Gaspar, M. L.; Jesch, S. A.; Marvalim, C.; Prinz, W. A.; Henry, S. A.; Thibault, G.
10.1101/2020.04.06.027847 — cell biology — Posted on 2020-04-15
2554 Butyrate producing Clostridiales utilize distinct human milk oligosaccharides correlating to early colonization and prevalence in the human gut
Pichler, M. J.; Yamada, C.; Shuoker, B.; Alvarez-Silva, C.; Gotoh, A.; Leth, M. L.; Schoof, E.; Katoh, T.; Sakanaka, M.; Katayama, T.; Jin, C.; Karlsson, N. G.; Arumugam, M.; Fushinobu, S.; Abou Hachem, M.
10.1101/2020.04.15.038927 — microbiology — Posted on 2020-04-15
2555 Prevention and Treatment of SHIVAD8 Infection in Rhesus Macaques by a Potent D-peptide HIV Entry Inhibitor
Nishimura, Y.; Francis, J. N.; Donau, O.; Jesteadt, E.; Sadjadpour, R.; Smith, A. R.; Seaman, M. S.; Welch, B. D.; Martin, M. A.; Kay, M. S.
10.1101/2020.04.14.041764 — microbiology — Posted on 2020-04-15
2556 Expanding the space of protein geometries by computational design of de novo fold families
Pan, X.; Thompson, M.; Zhang, Y.; Lin, L.; Fraser, J. S.; Kelly, M. J. S.; Kortemme, T.
10.1101/2020.04.14.041772 — bioengineering — Posted on 2020-04-15
2559 Actin binding domain of Rng2 strongly inhibits actin movement on myosin II HMM through structural changes of actin filaments
Hayakawa, Y.; Takaine, M.; Imai, T.; Yamada, M.; Hirose, K.; Tokuraku, K.; Ngo, K. X.; Kodera, N.; Numata, O.; Nakano, K.; Uyeda, T.
10.1101/2020.04.14.041046 — biophysics — Posted on 2020-04-15
2562 α-catenin regulates cell junction fluidity by cooperative mechanosensing
Arbore, C.; Sergides, M.; Gardini, L.; Pavone, F. S.; Capitanio, M.
10.1101/2020.04.15.035527 — biophysics — Posted on 2020-04-15
2563 Improved control of Septoria tritici blotch in durum wheat using cultivar mixtures
Ben M'Barek, S.; Karisto, P.; Abdedayem, W.; Laribi, M.; Fakhfakh, M.; Kouki, H.; Mikaberidze, A.; Yahyaoui, A.
10.1101/664078 — plant biology — Posted on 2020-04-15
2564 Characterizing the portability of RecT-mediated oligonucleotide recombination
Filsinger, G.; Wannier, T.; Pedersen, F. B.; Zhang, J.; Lutz, I.; Stork, D.; Debnath, A.; Gozzi, K.; Kuchwara, H.; Volf, V.; Wang, S.; Rios, X.; Gregg, C.; Lajoie, M.; Shipman, S.; Aach, J.; Laub, M.; Church, G.
10.1101/2020.04.14.041095 — synthetic biology — Posted on 2020-04-15
2565 Large-scale nuclear remodeling and transcriptional deregulation occur on both derivative chromosomes after Mantle cell lymphoma chromosomal translocation
Sall, F. B.; Pichugin, A.; Iarovaia, O.; Barat, A.; Tsfasman, T.; Brossas, C.; Prioleau, M.-N.; Sheval, E. V.; Zharikova, A. A.; Lazarovici, J.; Camara-Clayette, V.; Ribrag, V.; Lipinski, M.; Vassetzky, Y.; Germini, D.
10.1101/2019.12.30.882407 — cancer biology — Posted on 2020-04-15
2566 Charting the metabolic landscape of the facultative methylotroph Bacillus methanolicus
Delepine, B.; Gil Lopez, M.; Carnicer, M.; Vicente, C. M.; Wendisch, V. F.; Heux, S.
10.1101/858514 — systems biology — Posted on 2020-04-15
2567 A multi-layered and dynamic apical extracellular matrix shapes the vulva lumen in Caenorhabditis elegans
Cohen, J. D.; Sparacio, A. P.; Belfi, A. C.; Forman-Rubinsky, R.; Hall, D. H.; Maul-Newby, H.; Frand, A. R.; Sundaram, M. V.
10.1101/2020.04.14.041483 — developmental biology — Posted on 2020-04-15
2568 Cotranslational folding cooperativity of contiguous domains of α-spectrin
Kemp, G.; Nilsson, O. B.; Tian, P.; Best, R. B.; Von Heijne, G.
10.1101/653360 — biochemistry — Posted on 2020-04-15
2570 Ecological and anthropogenic drivers of large carnivore depredation on sheep in Europe
Gervasi, V.; Linnell, J.; Berce, T.; Boitani, L.; Cerne, R.; Cretois, B.; Ciucci, P.; Duchamp, C.; Gastineau, A.; Grente, O.; Hilfiker, D.; Huber, D.; Iliopoulos, Y.; Karamanlidis, A.; Marucco, F.; Mertzanis, Y.; Mannil, P.; Norberg, H.; Pagon, N.; Pedrotti, L.; Quenette, P.-Y.; Reljic, S.; Salvatori, V.; Talvi, T.; von Arx, M.; Gimenez, O.
10.1101/2020.04.14.041160 — ecology — Posted on 2020-04-15
2571 Deep Active Inference and Scene Construction
Heins, R. C.; Mirza, M. B.; Parr, T.; Friston, K.; Kagan, I.; Pooresmaeili, A.
10.1101/2020.04.14.041129 — neuroscience — Posted on 2020-04-15
2572 Inhibition of Wnt signalling by Notch via two distinct mechanisms
Acar, A.; Hidalgo-Sastre, A.; Leverentz, M. K.; Mills, C.; Woodcock, S.; Baron, M.; Collu, G.; Brennan, K.
10.1101/2020.04.14.037788 — cell biology — Posted on 2020-04-15
2573 A Deep Learning Pipeline for Nucleus Segmentation
Zaki, G.; Gudla, P. R.; Lee, K.; Ozbun, L.; Kim, J.; Shachar, S.; Gadkari, M.; Jing, S.; Fraser, I. D.; Franco, L. M.; Misteli, T.; Pegoraro, G.
10.1101/2020.04.14.041020 — cell biology — Posted on 2020-04-15
2574 Oleic acid Induces Tissue Resident FoxP3 Regulatory T cell Lineage Stability and Suppressive Functions
Pompura, S. L.; Wagner, A.; Kitz, A.; LaPerche, J.; Yosef, N.; Dominguez-Villar, M.; Hafler, D. A.
10.1101/2020.04.14.041525 — immunology — Posted on 2020-04-15
2575 Multivariate Analysis Of Potato Genotypes For Genetic Diversity
Khan, A.; Erum, S.; Riaz, N.; Shinwari, M. I.; Ibrar Shinwari, M.
10.1101/2020.04.14.041236 — genetics — Posted on 2020-04-15
2584 A spatiotemporal translatome of mouse tissue development
Wang, H.; Wang, Y.; Yang, J.; Tang, N.; Li, H.; Xie, M.; Xie, Z.
10.1101/2020.04.14.041079 — bioinformatics — Posted on 2020-04-15
2587 Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency
Crouse, R. B.; Kim, K.; Batchelor, H.; Kamaletdinova, R.; Chan, J.; Rajebhosale, P.; Pittenger, S.; Role, L.; Talmage, D.; Jing, M.; Li, Y.; Gao, X.-B.; Mineur, Y.; Picciotto, M.
10.1101/2020.04.14.041152 — neuroscience — Posted on 2020-04-15
2588 Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex
Halff, E. F.; Cotel, M. C.; Natesan, S.; McQuade, R.; Ottley, C. J.; Srivastiva, D. P.; Howes, O. D.; Vernon, A. C.
10.1101/2020.04.14.033944 — neuroscience — Posted on 2020-04-15
2589 Sleep Induction by Mechanosensory Stimulation in Drosophila
Ozturk-Colak, A.; McClanahan, P. D.; Buchler, J. R.; Inami, S.; Cruz, A.; Fang-Yen, C.; Koh, K.
10.1101/2020.04.14.041061 — neuroscience — Posted on 2020-04-15
2590 Streptococcus pyogenes M1T1 variants activate caspase-1 and induce an inflammatory neutrophil phenotype
Williams, J. G.; Ly, D.; Geraghty, N. J.; McArthur, J. D.; Vyas, H.; Gorman, J.; Tsatsaronis, J. A.; Sluyter, R.; Sanderson-Smith, M. L.
10.1101/2020.03.02.972240 — microbiology — Posted on 2020-04-15
2593 A pan-cancer landscape of somatic substitutions in non-unique regions of the human genome
Tarabichi, M.; Demeulemeester, J.; Verfaillie, A.; Flanagan, A. M.; Van Loo, P.; Konopka, T.
10.1101/2020.04.14.040634 — genomics — Posted on 2020-04-15
2594 Mating-type locus rearrangement leads to shift from homothallism to heterothallism in Citrus-associated Phyllosticta species
Petters-Vandresen, D. A.; Rossi, B. J.; Groenewald, J. Z.; Crous, P. W.; Machado, M. A.; Stukenbrock, E. H.; Glienke, C.
10.1101/2020.04.14.040725 — evolutionary biology — Posted on 2020-04-15
2596 Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
Petrany, M.; Swoboda, C.; Sun, C.; Chetal, K.; Chen, X.; Weirauch, M.; Salomonis, N.; Millay, D.
10.1101/2020.04.14.041400 — cell biology — Posted on 2020-04-15
2597 The capacity of the ovarian cancer tumor microenvironment to integrate inflammation signaling conveys a shorter disease-free interval
Jordan, K. R.; Sikora, M. J.; Slansky, J. E.; Minic, A.; Richer, J. K.; Moroney, M. R.; Costello, J. C.; Clauset, A. G.; Behbakht, K.; Kumar, T. R.; Bitler, B. G.
10.1101/2020.04.14.041145 — cancer biology — Posted on 2020-04-15
2599 Structural insights into the mechanism of rhodopsin phosphodiesterase
Ikuta, T.; Shihoya, W.; Sugiura, M.; Yoshida, K.; Watari, M.; Tokano, T.; Yamashita, K.; Katayama, K.; Tsunoda, S. P.; Uchihashi, T.; Kandori, H.; Nureki, O.
10.1101/2020.04.14.040642 — biophysics — Posted on 2020-04-15
2601 The global population of SARS-CoV-2 is composed of six major subtypes
Morais Junior, I. J.; Costa Polveiro, R.; Souza, G. M.; Bortolin, D. I.; Sassaki, F. T.; Lima, A. T. M.
10.1101/2020.04.14.040782 — bioinformatics — Posted on 2020-04-15
2602 COVID-19 Knowledge Graph: a computable, multi-modal, cause-and-effect knowledge model of COVID-19 pathophysiology
Domingo-Fernandez, D.; Baksi, S.; Schultz, B. T.; Gadiya, Y.; Karki, R.; Raschka, T.; Ebeling, C.; Hofmann-Apitius, M.; Kodamullil, A. T.
10.1101/2020.04.14.040667 — bioinformatics — Posted on 2020-04-15
2603 Screening for inborn errors of metabolism using untargeted metabolomics and out-of-batch controls
Bongaerts, M.; Bonte, R.; Demirdas, S.; Jacobs, E.; Oussoren, E.; van der Ploeg, A.; Wagenmakers, M.; Hofstra, R.; Reinders, M.; Blom, H.; Ruijter, G.
10.1101/2020.04.14.040469 — bioinformatics — Posted on 2020-04-15
2607 Tissue tropisms of avian influenza A viruses affect their spillovers from wild birds to pigs
Zhang, X.; Cummingham, F.; Li, L.; Hanson-Dorr, K.; Liu, L.; Waters, K.; Guan, M.; Olivier, A.; Schmit, B.; Nolting, J.; Bowman, A.; Torchetti, M.; DeLiberto, T.; Wan, X.-F.
10.1101/2020.04.14.040964 — microbiology — Posted on 2020-04-14
2611 Ancestry-Specific Predisposing Germline Variants in Cancer
Oak, N.; Cherniak, A. D.; Mashl, R. J.; TCGA Analysis Network, ; Hirsch, F. R.; Ding, L.; Beroukhim, R.; Gumus, Z.; Plon, S. E.; Huang, K.-l.
10.1101/2020.04.14.032557 — genomics — Posted on 2020-04-14
2615 Novel BRAF gene fusions in pediatric histiocytic neoplasms define distinct therapeutic responsiveness to RAF paradox breakers
Jain, P.; Surrey, L. F.; Straka, J.; Russo, P.; Womer, R.; Li, M.; Storm, P. B.; Waanders, A. J.; Hogarty, M. D.; Resnick, A. C.; Picarsic, J.
10.1101/2020.04.13.039032 — cancer biology — Posted on 2020-04-14
2616 Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 A
Flores, J. A.; Haddad, B. G.; Dolan, K. A.; Myers, J. B.; Yoshioka, C. C.; Copperman, J.; Zuckerman, D. M.; Reichow, S. L.
10.1101/2020.04.14.036384 — biophysics — Posted on 2020-04-15
2617 Molecular recognition and dynamics of linear poly-ubiquitins: integrating coarse-grain simulations and experiments
Jussupow, A.; Messias, A. C.; Stehle, R.; Geerlof, A.; Solbak, S. M. O.; Bach, A.; Sattler, M.; Camilloni, C.
10.1101/2020.04.14.041327 — biophysics — Posted on 2020-04-14
2618 Suitability of resampled multispectral datasets for mapping flowering plants in the Kenyan savannah
Makori, D. M.; Abdel-Rahman, E. M.; Landmann, T. M.; Mutanga, O.; Odindi, J.; Nguku, E. M.; Tonnang, H. E.; Raina, S. M.
10.1101/2020.04.14.040956 — ecology — Posted on 2020-04-14
2619 A new automated chilled adult release system for the aerial distribution of sterile male tsetse flies
Mirieri, C.; Mutika, G. N.; Bruno, J.; Seck, M. T.; Sall, B.; Parker, A. G.; van Oers, M. M.; Vreysen, M. J. B.; Bouyer, B.; Abd-Alla, A. M. M.
10.1101/2020.04.14.040915 — pathology — Posted on 2020-04-14
2623 Dietary supplementation with products of Citrus reticulata "Chachi" for improving the fecal microbiome of weaned piglets
Lin, H.; Li, G.; Wang, H.; Li, L.; Chen, X.; Shi, L.; Tang, Y.; Chang, Y.; Yang, J.; Liu, Y.; Gong, H.
10.1101/2020.04.14.040881 — microbiology — Posted on 2020-04-14
2625 Assessing the effect of insecticide-treated cattle on tsetse abundance and trypanosome transmission at the wildlife-livestock interface in Serengeti, Tanzania
Lord, J. S.; Lea, R. S.; Allan, F.; Byamungu, M.; Hall, D.; Lingley, J.; Mramba, F.; Paxton, E.; Vale, G.; Hargrove, J.; Morrison, L.; Torr, S.; Auty, H.
10.1101/2020.04.14.040873 — ecology — Posted on 2020-04-14
2627 Genetic control of Campylobacter colonisation in broiler chickens: genomic and transcriptomic characterisation
Psifidi, A.; Kranis, A.; Rothwell, L.; Bremmer, A.; Russell, K.; Robledo, D.; Bush, S.; Fife, M.; Hocking, P.; Banos, G.; Hume, D.; Kaufman, J.; Bailey, R. A.; Avendano, S.; Watson, K.; Kaiser, P.; Stevens, M.
10.1101/2020.04.14.040832 — genomics — Posted on 2020-04-14
2628 Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion
Li, Z. d.; Zhang, W.; Luo, f.; Li, j.; Yang, W. b.; Zhu, B. k.; Wu, Q. f.; Wang, X. l.; Sun, C. s.; Xie, Y. x.; Xu, B.; Wang, Z. j.; Qian, F.; Wan, Y. m.; Li, Q.
10.1101/2020.04.14.040998 — immunology — Posted on 2020-04-14
2629 DeepRC: Immune repertoire classification with attention-based deep massive multiple instance learning
Widrich, M.; Schäfl, B.; Pavlovic, M.; Sandve, G. K.; Hochreiter, S.; Greiff, V.; Klambauer, G.
10.1101/2020.04.12.038158 — bioinformatics — Posted on 2020-04-14
2632 Simulating flow induced migration in vascular remodelling
Tabibian, A.; Ghaffari, S.; Vargas, D.; Van Oosterwyck, H.; Jones, E. A.
10.1101/2020.04.14.040840 — developmental biology — Posted on 2020-04-14
2634 Does the Antisecretory Peptide AF-16 modulate fluid balance and inflammation in experimental peritonitis induced sepsis?
Barrueta Tenhunen, A.; Tenhunen, J.; van der Heijden, J.; Blokhin, I.; Massaro, F.; Larsson, A.; Hansson, H. A.; Feinstein, R.
10.1101/2020.04.14.040857 — pathology — Posted on 2020-04-14
2636 Synaptotagmin-7 is a calcium sensor for facilitation at the splanchnic-chromaffin cell synapse
Caballero-Floran, R. N.; Bendahmane, M.; Philippe, J. M.; Mohan, R.; Schenk, N. A.; Zhang, S.; Valenta, A.; Sorensen, M. J.; Kennedy, R. T.; Heuser, J. E.; Anantharam, A.; Jenkins, P. M.
10.1101/2020.04.13.039768 — neuroscience — Posted on 2020-04-14
2639 The prevalence and genomic context of Shiga toxin 2a genes in E. coli found in cattle
Jinnerot, T.; Tomaselli, A. T. P.; Johannessen, G. S.; Söderlund, R.; Urdahl, A. M.; Aspan, A.; Sekse, C.
10.1101/2020.04.14.040899 — microbiology — Posted on 2020-04-14
2642 Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing
Atwell, S.; Lieu, R.; Antonysamy, S.; Druzina, Z.; Ho, C.; Kang, R. N.; Pustilnik, A.; Wang, J.
10.1101/2020.04.14.040949 — immunology — Posted on 2020-04-14
2643 One is not enough: on the effects of reference genome for the mapping and subsequent analyses of short-reads
Valiente-Mullor, C.; Beamud Aranguren, B.; Ansari, I.; Frances-Cuesta, C.; Garcia-Gonzalez, N.; Mejia, L.; Ruiz-Hueso, P.; Gonzalez-Candelas, F.
10.1101/2020.04.14.041004 — genomics — Posted on 2020-04-14
2644 FUS gene is dual-coding with both proteins united in FUS-mediated toxicity
Brunet, M. A.; Jacques, J.-F.; Nassari, S.; Tyzack, G. E.; McGoldrick, P.; Zinman, L.; Jean, S.; Robertson, J.; Patani, R.; Roucou, X.
10.1101/848580 — genetics — Posted on 2020-04-14
2645 Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits
Mao, T.-R.; Liu, Y.-W.; Meegaskumbura, M.; Yang, J.; Ellepola, G.; Senevirathne, G.; Fu, C.-H.; Gross, J. B.; Pie, M. R.
10.1101/2020.04.12.038034 — evolutionary biology — Posted on 2020-04-14
2647 The conservation status and population decline of the African penguin deconstructed in space and time
Sherley, R. B.; Crawford, R. J. M.; de Blocq, A. D.; Dyer, B. M.; Geldenhuys, D.; Hagen, C.; Kemper, J.; Makhado, A. B.; Pichegru, L.; Tom, D. B.; Upfold, L.; Visagie, J.; Waller, L. J.; Winker, H.
10.1101/2020.01.15.907485 — ecology — Posted on 2020-04-14
2649 DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming
Wu, B.; Li, Y.; Li, B.; Zhang, B.; Wang, Y.; Li, L.; Peng, G.; Fu, Y.; Li, S.; Chen, C.; Surani, A.; Tang, F.; Li, X.; Bao, S.
10.1101/2020.03.17.994939 — cell biology — Posted on 2020-04-14
2650 CRISPR-based screens uncover determinants of immunotherapy response in Multiple Myeloma
Ramkumar, P.; Abarientos, A. B.; Tian, R.; Seyler, M.; Leong, J. T.; Chen, M.; Choudhry, P.; Hechler, T.; Shah, N.; Wong, S. W.; Martin, T. G.; Wolf, J. L.; Roybal, K. T.; Pahl, A.; Taunton, J.; Wiita, A. P.; Kampmann, M.
10.1101/833707 — cancer biology — Posted on 2020-04-14
2651 Increased nuclear factor I/B expression in prostate cancer correlates with AR expression
Nanda, J. S.; Awadallah, W. N.; Kohrt, S. E.; Popovics, P.; Cates, J. M. M.; Mirosevich, J.; Clark, P. E.; Giannico, G. A.; Grabowska, M. M.
10.1101/684472 — cancer biology — Posted on 2020-04-14
2652 Large-scale nuclear remodeling and transcriptional deregulation occur on both derivative chromosomes after Mantle cell lymphoma chromosomal translocation
Sall, F. B.; Pichugin, A.; Iarovaia, O.; Barat, A.; Tsfasman, T.; Brossas, C.; Prioleau, M.-N.; Sheval, E. V.; Zharikova, A. A.; Lazarovici, J.; Camara-Clayette, V.; Ribrag, V.; Lipinski, M.; Vassetzky, Y.; Germini, D.
10.1101/2019.12.30.882407 — cancer biology — Posted on 2020-04-14
2654 Gait analysis of healthy rhesus monkeys using a pressure-sensing walkway system
Won, J.; Kim, K.; Yeo, H.-G.; Park, J.; Seo, J.; Kim, Y. G.; Park, S.-H.; Choi, W. S.; Jeon, C.-Y.; Lim, K. S.; Huh, J.-W.; Kim, Y.-H.; Jeong, J.; Choi, J.-W.; Lee, Y.
10.1101/2020.04.14.040907 — animal behavior and cognition — Posted on 2020-04-14
2658 Circuit-specific dendritic development in the piriform cortex
Moreno-Velasquez, L.; Kaehne, M.; Lo, H.; Lenzi, S.; Breustedt, J.; Schmitz, D.; Rüdiger, S.; Johenning, F.
10.1101/868075 — neuroscience — Posted on 2020-04-14
2660 Tissue-specific expression of young small-scale duplications in human central nervous systemregions
Brohard-Julien, S.; Frouin, V.; Meyer, V.; Chalabi, S.; Deleuze, J.-F.; Le Floch, E.; Battail, C.
10.1101/821256 — genomics — Posted on 2020-04-14
2661 Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitment
Mournetas, V.; Massourides, E.; Dupont, J.-B.; Kornobis, E.; Polveche, H.; Jarrige, M.; Gosselin, M. R. F.; Manousopoulou, A.; Garbis, S. D.; Gorecki, D. C.; Pinset, C.
10.1101/720920 — developmental biology — Posted on 2020-04-14
2663 Polygenic Score of Intelligence is More Predictive of Crystallized than Fluid Performance Among Children
Loughnan, R.; Palmer, C. E.; Thompson, W. K.; Dale, A. M.; Jernigan, T. L.; Fan, C. C.
10.1101/637512 — neuroscience — Posted on 2020-04-14
2666 CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic
Akther, S.; Bezrucenkovas, E.; Sulkow, B.; Panlasigui, C.; Li, L.; Qiu, W.; Di, L.
10.1101/2020.04.10.036343 — evolutionary biology — Posted on 2020-04-14
2668 Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics
Si, L.; Bai, H.; Rodas, M.; Cao, W.; Oh, C. Y.; Jiang, A.; Nurani, A.; Zhu, D. Y.; Goyal, G.; Gilpin, S.; Prantil-Baun, R.; Ingber, D. E.
10.1101/2020.04.13.039917 — microbiology — Posted on 2020-04-14
2669 Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection
Wang, A.; Chiou, J. A.; Poirion, O. B.; Buchanan, J.; Valdez, M. J.; Verheyden, J. M.; Hou, X.; Guo, M.; Newsome, J. M.; Kudtarkar, P.; Faddah, D. A.; Zhang, K.; Young, R. E.; Barr, J.; Misra, R.; Huyck, H.; Rogers, L.; Poole, C.; Whitsett, J. A.; Pryhuber, G.; Xu, Y.; Gaulton, K. J.; Preissl, S.; Sun, X.; NHLBI LungMap Consortium,
10.1101/2020.04.12.037580 — genomics — Posted on 2020-04-14
2670 The origin and underlying driving forces of the SARS-CoV-2 outbreak
Chaw, S.-M.; Tai, J.-H.; Chen, S.-L.; Hsieh, C.-H.; Chang, S.-Y.; Yeh, S.-H.; Yang, W.-S.; Chen, P.-J.; Wang, H.-Y.
10.1101/2020.04.12.038554 — evolutionary biology — Posted on 2020-04-14
2671 Improving COVID-19 Testing Efficiency using Guided Agglomerative Sampling
Minhas, F.; Grammatopoulos, D.; Young, L.; Amin, I.; Snead, D.; Anderson, N.; Ben-Hur, A.; Rajpoot, N.
10.1101/2020.04.13.039792 — bioinformatics — Posted on 2020-04-14
2674 Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro
Su, H.; Yao, S.; Zhao, W.; Li, M.; Liu, J.; Shang, W.; Xie, H.; Ke, C.; Gao, M.; Yu, K.; Liu, H.; Shen, J.; Tang, W.; Zhang, L.; Zuo, J.; Jiang, H.; Bai, F.; Wu, Y.; Ye, Y.; Xu, Y.
10.1101/2020.04.13.038687 — molecular biology — Posted on 2020-04-14
2679 Mechanics Of Flight Feathers: Effects Of Captivity?
Portugal, S.; Nudds, R.; Green, J.; Alexander, R.; Butler, P.; Ker, R.
10.1101/2020.04.14.038877 — zoology — Posted on 2020-04-14
2682 Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity.
Kozlova, E. V.; Hegde, S.; Roundy, C. M.; Golovko, G.; Saldana, M. A.; Hart, C. E.; Anderson, E. R.; Hornett, E. A.; Khanipov, K.; Popov, V. L.; Pimenova, M.; Zhou, Y.; Fovanov, Y.; Weaver, S. C.; Routh, A. L.; Heinz, E.; Hughes, G. L.
10.1101/2020.04.14.039701 — microbiology — Posted on 2020-04-14
2685 A widely distributed hydrogenase oxidises atmospheric H2 during bacterial growth
Islam, Z. F.; Welsh, C.; Bayly, K.; Grinter, R.; Southam, G.; Gagen, E. J.; Greening, C.
10.1101/2020.04.14.040717 — microbiology — Posted on 2020-04-14
2687 Cat fleas in flux: Rampant gene duplication, genome size plasticity, and paradoxical Wolbachia infection
Driscoll, T.; Verhoeve, V. I.; Gillespie, J. J.; Johnston, S.; Guillotte, M.; Bankert, K. E.; Rahman, M. S.; Hagen, D.; Elsik, C. G.; Macaluso, K. R.; Azad, A. F.
10.1101/2020.04.14.038018 — genomics — Posted on 2020-04-14
2690 Temporal ordering of omics and multiomic events inferred from time series data
Kaur, S.; Peters, T. J.; Yang, P.; Luu, L. D. W.; Vuong, J.; Krycer, J. R.; O'Donoghue, S. I.
10.1101/2020.04.14.040527 — bioinformatics — Posted on 2020-04-14
2691 Resolving the species pool dependence of beta-diversity using coverage-based rarefaction
Engel, T.; Blowes, S. A.; McGlinn, D. J.; May, F.; Gotelli, N. J.; McGill, B. J.; Chase, J. M.
10.1101/2020.04.14.040402 — ecology — Posted on 2020-04-14
2693 Triplet-based similarity score for fully multi-labeled trees with poly-occurring labels
Ciccolella, S.; Bernardini, G.; Denti, L.; Bonizzoni, P.; Previtali, M.; Della Vedova, G.
10.1101/2020.04.14.040550 — bioinformatics — Posted on 2020-04-14
2696 In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning
Kranich, J.; Chlis, N.-K.; Rausch, L.; Latha, A.; Schifferer, M.; Kurz, T.; Foltyn, A.; Simons, M.; Theis, F. J.; Brocker, T.
10.1101/2020.04.14.040691 — cell biology — Posted on 2020-04-14
2698 Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family
Tugaeva, K. V.; Titterington, J.; Sotnikov, D. V.; Maksimov, E. G.; Antson, A. A.; Sluchanko, N. N.
10.1101/2020.04.14.040436 — biochemistry — Posted on 2020-04-14
2699 Visual attention modulates the integration of goal-relevant evidence and not value
Sepulveda, P.; Usher, M.; Davies, N.; Benson, A.; Ortoleva, P.; De Martino, B.
10.1101/2020.04.14.031971 — neuroscience — Posted on 2020-04-14
2700 Single-cell transcriptomic profiling maps monocyte/macrophage transitions after myocardial infarction in mice
Rizzo, G.; Vafadarnejad, E.; Arampatzi, P.; Silvestre, J.-S.; Zernecke, A.; Saliba, A.-E.; Cochain, C.
10.1101/2020.04.14.040451 — immunology — Posted on 2020-04-14
2701 Induction of long-lived potential aestivation states in laboratory An. gambiae mosquitoes
Krajacich, B. J.; Sullivan, M.; Faiman, R.; Veru, L.; Graber, L.; Lehmann, T.
10.1101/2020.04.14.031799 — ecology — Posted on 2020-04-14
2702 Longitudinal alterations in fronto-striatal glutamate are associated with functioning during inhibitory control in autism spectrum disorder and obsessive compulsive disorder
Hollestein, V.; Buitelaar, J. K.; Brandeis, D.; Banaschewski, T.; Kaiser, A.; Hohmann, S.; Oranje, B.; Gooskens, B.; Durston, S.; Lythgoe, D. J.; Naaijen, J.
10.1101/2020.04.14.031740 — neuroscience — Posted on 2020-04-14
2703 Mapping the genetic and environmental aetiology of autistic traits in Sweden and the UK
Reed, Z. E.; Larsson, H.; Haworth, C. M. A.; Rai, D.; Lundstrom, S.; Ronald, A.; Reichenberg, A.; Lichtenstein, P.; Davis, O. S. P.
10.1101/2020.04.14.031518 — genetics — Posted on 2020-04-14
2705 Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation
Esteva-Font, C.; Su, T.; Peaslee, C.; Duwaerts, C.; Liu, K.; Medina, M.; Maher, J. J.; Mattis, A. N.
10.1101/2020.04.13.034595 — developmental biology — Posted on 2020-04-14
2706 Cabozantinib unlocks efficient in vivo targeted delivery of neutrophil-loaded nanoparticles into murine prostate tumors
Chaudagar, K.; Landon-Brace, N.; Solanki, A.; Hieromnimon, H. M.; Hegermiller, E.; Li, W.; Shao, Y.; Wilkins, D.; Bynoe, K.; Li, X.-L.; Clohessy, J.; Ullas, S.; Karp, J.; Patnaik, A.
10.1101/2020.04.13.037531 — cancer biology — Posted on 2020-04-14
2707 Analysis of ISCB honorees and keynotes reveals disparities
Le, T. T.; Himmelstein, D. S.; Hippen Anderson, A. A.; Gazzara, M. R.; Greene, C. S.
10.1101/2020.04.14.927251 — bioinformatics — Posted on 2020-04-14
2711 Proteomic fingerprint identification of Neotropical hard tick species (Acari: Ixodidae) using a self-curated mass spectra reference library
Gittens, R. A.; Almanza, A.; Alvarez, E.; Bennett, K.; Mejia, L. C.; Sanchez-Galan, J. E.; Merchan, F.; Kern, J.; Miller, M. J.; Esser, H. J.; Hwang, R.; Dong, M.; De Leon, L. F.; Loaiza, J. R.
10.1101/2020.04.13.040089 — zoology — Posted on 2020-04-14
2712 Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies
Mackie, B. D.; Chen, D.; Dong, G.; Dong, C.; Parker, H.; Noinaj, N.; Schaner Tooley, C. E.; Min, J.; Huang, R.
10.1101/2020.04.13.040139 — biochemistry — Posted on 2020-04-14
2713 Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens
Kumar, S.; Li, J.; Park, J.; Hart, S. K.; Bean, N. L.; Song, N. J.; Coler-Reilly, A.; Jacobs, N. C.; Burrow, D. T.; Onyshchenko Pendergrass, A.; Pierre, T. H.; Bradley, I. C.; Varadarajan, M.; Carette, J. E.; Brummelkamp, T. R.; Dolle, R. E.; Peterson, T. R.
10.1101/2020.04.10.035683 — genomics — Posted on 2020-04-14
2714 rcs5-mediated spot blotch resistance in barley is conferred by wall-associated kinases that resist pathogen manipulation
Ameen, G.; Solanki, S.; Drader, T.; Sager-Bittara, L.; Steffenson, B.; Kleinhofs, A.; Vogiatzis, C.; Brueggeman, R. S.
10.1101/2020.04.13.040238 — plant biology — Posted on 2020-04-14
2717 An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats
Luo, T. Z.; Bondy, A. G.; Gupta, D.; Elliott, V. A.; Kopec, C. D.; Brody, C. D.
10.1101/2020.04.13.039305 — neuroscience — Posted on 2020-04-14
2720 Comprehensive transcriptome data of normal and Ascosphaera apis-infected western honeybee larval guts
Du, Y.; Wang, J.; Zhu, Z.; Jiang, H.; Fan, X.; Fan, Y.; Zheng, Y.; Xiong, C.; Chen, D.; Guo, R.
10.1101/2020.04.11.037598 — molecular biology — Posted on 2020-04-14
2721 Rapid, precise quantification of large DNA excisions and inversions by ddPCR
Watry, H. L.; Feliciano, C. M.; Gjoni, K.; Takahashi, G.; Miyaoka, Y.; Conklin, B. R.; Judge, L. M.
10.1101/2020.04.13.039297 — molecular biology — Posted on 2020-04-14
2722 A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection
Karuna, R.; Yokokawa, F.; Wang, K.; Zhang, J.; Xu, H.; Wang, G.; Ding, M.; Chan, W. L.; Abdul Ghafar, N.; Leonardi, A.; Seh, C. C.; Seah, P. G.; Liu, W.; Rao, S. P. S.; Lim, S. P.; Lakshminarayana, S. B.; Growcott, E. J.; Babu, S.; Fenaux, M.; Zhong, W.; Gu, F.; Shi, P.-Y.; Blasco, F.; Chen, Y.-L.
10.1101/2020.04.13.040287 — microbiology — Posted on 2020-04-14
2723 Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses
Brar, G.; Farhat, N. A.; Sukhina, A.; Lam, A. K.; Kim, Y. H.; Hsu, T.; Tong, L.; Lin, W. W.; Ware, C. F.; Blackman, M. A.; Sun, R.; Wu, T.-T.
10.1101/2020.04.13.034082 — microbiology — Posted on 2020-04-14
2724 A novel dual antibody staining assay to measure estrogen receptor transcriptional activity
van Hemert, F.; Dam-de Veen, C.; Konings, S.; van der Ven, J.; van de Stolpe, A.
10.1101/2020.04.14.021782 — cell biology — Posted on 2020-04-14
2726 Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM
Zhao, K.; Lim, Y.-J.; Liu, Z.; Long, H.; Sun, Y.; Hu, J.-J.; Zhao, C.; Tao, Y.; Zhang, X.; Li, D.; Li, Y.-M.; Liu, C.
10.1101/2020.04.13.040261 — biophysics — Posted on 2020-04-14
2736 Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.
Brumfield, A.; Chaudhary, N.; Molle, D.; Wen, J.; Graumann, J.; McGraw, T. E.
10.1101/2020.04.14.040683 — cell biology — Posted on 2020-04-14
2740 The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryo
Placentino, M.; Domingues, A. M. d. J.; Schreier, J.; Dietz, S.; Hellmann, S.; de Albuquerque, B.; Butter, F.; Ketting, R. F.
10.1101/2020.04.14.040584 — molecular biology — Posted on 2020-04-14
2741 CBL mutations promote activation of PI3K/AKT signaling via LYN kinase
Belizaire, R.; Koochaki, S. H. J.; Udeshi, N.; Vedder, A.; Sun, L.; Svinkina, T.; Hartigan, C.; Stanclift, C.; Schenone, M.; Carr, S. A.; Padron, E.; Ebert, B. L.
10.1101/2020.04.13.038448 — cancer biology — Posted on 2020-04-14
2742 RNA matchmaking remodels lncRNA structure and promotes PRC2 activity
Balas, M. M.; Hartwick, E. W.; Barrington, C.; Roberts, J. T.; Wu, S. K.; Bettcher, R.; Griffin, A. M.; Kieft, J. S.; Johnson, A. M.
10.1101/2020.04.13.040071 — biochemistry — Posted on 2020-04-14
2744 A spatially explicit and mechanistic model for exploring coral reef dynamics
Carturan, B. S.; Marechal, J.-P.; Bradshaw, C. J. A.; Pither, J.; Parrott, L.
10.1101/2020.04.11.036913 — bioinformatics — Posted on 2020-04-14
2746 Ahr-bacterial diet interaction modulates aging and associated pathologies in C. elegans
Brinkmann, V.; Schiavi, A.; Shaik, A.; Puchta, D. R.; Menzel, R.; Ventura, N.
10.1101/2020.04.13.021246 — physiology — Posted on 2020-04-14
2747 Proteome analysis of human visceral and subcutaneous adipocytes identifies depot-specific heterogeneity at metabolic control points
Raajendiran, A.; Krisp, C.; De Souza, D. P.; Ooi, G.; Burton, P. R.; Taylor, R. A.; Molloy, M.; Watt, M. J.
10.1101/2020.04.13.039057 — physiology — Posted on 2020-04-14
2749 The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations.
Kim, J.; Cai, F.; Ko, B.; Yang, C.; Lee, H. M.; Muhammad, N.; Li, K.; Haloul, M.; Gu, W.; Faubert, B.; Kaushik, A. K.; Cai, L.; Kasiri, S.; Marriam, U.; Nham, K.; Girard, L.; Wang, H.; Sun, X.; Kim, J.; Minna, J.; Unsal-Kacmaz, K.; DeBerardinis, R. J.
10.1101/2020.04.13.039669 — cancer biology — Posted on 2020-04-14
2751 Distinct CD8+ T Cell Programming in the Tumor Microenvironment Contributes to Sex Bias in Bladder Cancer Outcome
Kwon, H.; Chung, D.; Kaneko, S.; Li, A.; Zhou, L.; Riesenberg, B.; Song, N.-J.; Sundi, D.; Li, X.; Li, Z.
10.1101/2020.04.13.039735 — immunology — Posted on 2020-04-14
2753 sureLDA: A Multi-Disease Automated Phenotyping Method for the Electronic Health Record
Ahuja, Y.; Zhou, D.; He, Z.; Sun, J.; Castro, V. M.; Gainer, V.; Murphy, S. N.; Hong, C.; Cai, T.
10.1101/2020.04.13.038968 — bioinformatics — Posted on 2020-04-14
2754 Caspases from Scleractinian Coral Show Unique Regulatory Features
Shrestha, S.; Tung, J.; Grinshpon, R. D.; Swartz, P. D.; Hamilton, P. T.; Mydlarz, L.; Clark, C.
10.1101/2020.04.13.039685 — biochemistry — Posted on 2020-04-14
2755 Control of mammalian brain aging by the unfolded protein response (UPR)
Cabral Miranda, F.; Tamburini, G.; Martinez, G.; Medinas, D.; Gerakis, Y.; Miedema, T.; Duran-Aniotz, C.; Ardilles, A.; Ibaceta, C.; Sabusap, C.; Bermedo-Garcia, F.; Adamson, S.; Vitangcol, K.; Huerta, H.; Zhang, X.; Nakamura, T.; Sardi, P.; Lipton, S.; Kennedy, B.; Cardenas, J. C.; Palacios, A.; Plate, L.; Henriquez, J. P.; Hetz, C.
10.1101/2020.04.13.039172 — neuroscience — Posted on 2020-04-14
2756 Origin, Conservation, and Loss of Alternative Splicing Events that Diversify the Proteome in Saccharomycotina Budding Yeasts
Hurtig, J.; Kim, M.; Orlando-Coronel, L.; Ewan, J.; Foreman, M.; Notice, L.-A.; Steiger, M.; van Hoof, A.
10.1101/2020.04.13.039594 — genetics — Posted on 2020-04-14
2757 PLK1- and PLK4-mediated asymmetric mitotic centrosome size and positioning in the early zebrafish embryo.
Rathbun, L.; Aljiboury, A. A.; Bai, X.; Manikas, J. E.; Amack, J. D.; Bembenek, J. N.; Hehnly, H.
10.1101/2020.04.13.039362 — cell biology — Posted on 2020-04-14
2763 Modeling disease-correlated TUBA1A mutation in budding yeast reveals a molecular basis for tubulin dysfunction
Denarier, E.; Ecklund, K. H.; Berthier, G.; Favier, A.; Gory, S.; De Macedo, L.; Delphin, C.; Andrieux, A.; Markus, S. M.; Boscheron, C.
10.1101/2020.04.13.039982 — cell biology — Posted on 2020-04-14
2764 SETD2 is an actin lysine methyltransferase
Seervai, R. N. H.; Jangid, R. K.; Karki, M.; Tripathi, D. N.; Jung, S. Y.; Kearns, S. E.; Verhey, K. J.; Cianfrocco, M. A.; Millis, B. A.; Tyska, M. J.; Mason, F. M.; Rathmell, W. K.; Park, I. Y.; Dere, R.; Walker, C. L.
10.1101/2020.04.13.034629 — cell biology — Posted on 2020-04-14
2765 Cryo-EM structures reveal transcription initiation steps by yeast mitochondrial RNA polymerase
De Wijngaert, B.; Sultana, S.; Dharia, C.; Vanbuel, H.; Shen, J.; vasilchuk, D.; Martinez, S. E.; Kandiah, E.; Patel, S. S.; Das, K.
10.1101/2020.04.13.038620 — biophysics — Posted on 2020-04-14
2766 Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling
Nyman, E.; Lindh, M.; Lovfors, W.; Simonsson, C.; Persson, A.; Eklund, D.; Backstrom, E.; Friden, M.; Cedersund, G.
10.1101/2020.04.13.031245 — systems biology — Posted on 2020-04-14
2767 Synaptotagmin-7 is a calcium sensor for facilitation at the splanchnic-chromaffin cell synapse
Caballero-Floran, R. N.; Bendahmane, M.; Philippe, J. M.; Mohan, R.; Schenk, N. A.; Zhang, S.; Valenta, A.; Sorensen, M. J.; Kennedy, R. T.; Heuser, J. E.; Anantharam, A.; Jenkins, P. M.
10.1101/2020.04.13.039768 — neuroscience — Posted on 2020-04-14
2768 Neurophysiological signatures in the retrieval of individual autobiographical memories of real-life episodic events
Nicolas, B.; Wu, X.; Dimiccolli, M.; Sierpowska, J.; Saiz-Masvidal, C.; Soriano-Mas, C.; Radeva, P.; Fuentemilla, L.
10.1101/2020.04.13.039024 — neuroscience — Posted on 2020-04-14
2769 A Drosophila natural variation screen identifies NKCC1 as a substrate of NGLY1 deglycosylation and a modifier of NGLY1 deficiency
Talsness, D. M.; Owings, K. G.; Coelho, E.; Mercenne, G.; Pleinis, J. M.; Zuberi, A. R.; Partha, R.; Clark, N. L.; Lutz, C. M.; Rodan, A. R.; Chow, C. Y.
10.1101/2020.04.13.039651 — genomics — Posted on 2020-04-14
2770 Histone variants in archaea and the evolution of combinatorial chromatin complexity
Stevens, K. M.; Swadling, J. B.; Hocher, A.; Bang, C.; Gribaldo, S.; Schmitz, R. A.; Warnecke, T.
10.1101/2020.04.13.037952 — evolutionary biology — Posted on 2020-04-14
2772 The covariance shift (C-SHIFT) algorithm for normalizing biological data
Chunikhina, E.; Logan, P.; Kovchegov, Y.; Yambartsev, A.; Mondal, D.; Morgun, A.
10.1101/2020.04.13.038463 — bioinformatics — Posted on 2020-04-14
2779 A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species of Leptospira spp.
Wunder, E.; Adhikarla, H.; Hamond, C.; Owers, K.; Liang, L.; Rodrigues, C.; Bisht, V.; Nally, J.; Alt, D.; Reis, M.; Diggle, P.; Felgner, P.; Ko, A.
10.1101/2020.04.13.039438 — microbiology — Posted on 2020-04-14
2780 ISG15 drives immune pathology and respiratory failure during viral infection
Shaabani, N.; Zak, J.; Johnson, J. L.; Huang, Z.; Nguyen, N.; Lazar, D. C.; Vartabedian, V. F.; Honke, N.; Prinz, M.; Knobeloch, K.-P.; Arimoto, K.-i.; Zhang, D.-E.; Catz, S. D.; Teijaro, J. R.
10.1101/2020.04.13.039321 — immunology — Posted on 2020-04-14
2781 PathoLive - Real-time pathogen identification from metagenomic Illumina datasets
Tausch, S. H.; Loka, T. P.; Schulze, J. M.; Andrusch, A.; Klenner, J.; Dabrowski, P. W.; Lindner, M. S.; Nitsche, A.; Renard, B. Y.
10.1101/402370 — bioinformatics — Posted on 2020-04-14
2782 MS-CleanR: A feature-filtering approach to improve annotation rate in untargeted LC-MS based metabolomics
Fraisier-Vannier, O.; Chervin, J.; Cabanac, G.; Puech-Pages, V.; Fournier, S.; Durand, V.; Amiel, A.; Andre, O.; Benamar, O. A.; Dumas, B.; Tsugawa, H.; Marti, G.
10.1101/2020.04.09.033308 — bioinformatics — Posted on 2020-04-14
2785 Promoter scanning during transcription initiation in Saccharomyces cerevisiae: Pol II in the "shooting gallery"
Qiu, C.; Jin, H.; Vvedenskaya, I.; Llenas, J. A.; Zhao, T.; Malik, I.; Visbisky, A. M.; Schwartz, S. L.; Cui, P.; Cabart, P.; Han, K. H.; Lai, W. K. M.; Metz, R. P.; Johnson, C. D.; Sze, S.-H.; Pugh, B. F.; Nickels, B. E.; Kaplan, C. D.
10.1101/810127 — molecular biology — Posted on 2020-04-14
2786 Signatures of selection in the coral holobiont reveal complex adaptations to inshore environments driven by Holocene climate change
Cooke, I. R.; Ying, H.; Foret, S.; Bongaerts, P.; Strugnell, J. M.; Simakov, O.; Zhang, J.; Field, M. A.; Rodriguez-Lanetty, M.; Bell, S.; Bourne, D. G.; van Oppen, M.; Ragan, M. A.; Miller, D. J.
10.1101/2020.02.25.951905 — genomics — Posted on 2020-04-14
2790 Noradrenergic circuits in the forebrain control affective responses to novelty
Lustberg, D.; Tillage, R. P.; Bai, Y.; Pruitt, M.; Liles, L. C.; Weinshenker, D.
10.1101/2020.04.11.037200 — neuroscience — Posted on 2020-04-14
2800 PEDF-Rpsa-Itga6 signaling regulates cortical neuronal morphogenesis
Blazejewski, S. M.; Bennison, S. A.; Ha, N.; Liu, X.; Smith, T. H.; Dougherty, K. J.; Toyooka, K.
10.1101/2020.01.06.895672 — neuroscience — Posted on 2020-04-13
2802 Brain Angiopathy and Impaired Glucose Metabolism in Model Mice with Psychiatric-Related Phenotypes
Hirai, S.; Miwa, H.; Tanaka, T.; Toriumi, K.; Kunii, Y.; Hino, M.; Izumi, R.; Nagaoka, A.; Yabe, H.; Nakamachi, T.; Shioda, S.; Dan, T.; Miyata, T.; Nishito, Y.; Suzuki, K.; Miyashita, M.; Itokawa, M.; Arai, M.; Okado, H.
10.1101/2020.02.14.939546 — neuroscience — Posted on 2020-04-13
2803 Novel methodology for assessing total recovery time in response to unexpected perturbations while walking
Rosenblum, U.; Kribus-Shmiel, L.; Zeilig, G.; Bahat, Y.; Kimel-Naor, S.; Melzer, I.; Plotnik, M.
10.1101/846923 — neuroscience — Posted on 2020-04-13
2807 A Drosophila Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in Neurons
Morton, D. J.; Jalloh, B.; Kim, L.; Nair, R. J.; Kremsky, I.; Nguyen, K. B.; Rounds, J. C.; Sterrett, M. C.; Brown, B.; Le, T.; Karkare, M. C.; McGaughey, K. D.; Sheng, S.; Leung, S. W.; Fasken, M. B.; Moberg, K. H.; Corbett, A. H.
10.1101/727693 — genetics — Posted on 2020-04-13
2809 Novel insights into the taxonomic diversity and molecular mechanisms of bacterial Mn(III) reduction
Szeinbaum, N.; Nunn, B. L.; Cavazos, A. R.; Crowe, S. A.; Stewart, F. J.; DiChristina, T. J.; Reinhard, C. T.; Glass, J. B.
10.1101/695007 — microbiology — Posted on 2020-04-13
2811 BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
Edwards, D.; Maganti, R.; Tanksley, J. P.; Luo, J.; Park, J. J. H.; Balkanska-Sinclair, E.; Ling, J.; Floyd, S. R.
10.1101/854737 — cancer biology — Posted on 2020-04-13
2813 Aberrant Visual Population Receptive Fields in Human Albinism
Duwell, E. J.; Woertz, E. N.; Mathis, J.; Carroll, J.; DeYoe, E. A.
10.1101/572289 — neuroscience — Posted on 2020-04-13
2814 Analysis of the testicles transcriptome of the Chagas disease vector Rhodnius prolixus.
Cardoso, J. C.; Ribeiro, J. M. C.; dos Santos, D. V.; Pereira, M. H.; Araujo, R. N.; Gontijo, N. F.; Pessoa, G. C. D.; Sant'Anna, M. R. V.; Sorgine, M. H. F.; Majerowicz, D.; Medeiros, M.; Braz, G. R. C.; Mesquita, R. D.; Oliveira, P. L.; Koerich, L. B.
10.1101/616193 — genomics — Posted on 2020-04-13
2816 Phase resetting in human auditory cortex to visual speech
Megevand, P.; Mercier, M. R.; Groppe, D. M.; Zion Golumbic, E.; Mesgarani, N.; Beauchamp, M. S.; Schroeder, C. E.; Mehta, A. D.
10.1101/405597 — neuroscience — Posted on 2020-04-13
2819 Dicistronic tRNA-mRNA transcripts in grapevine (Vitis vinifera) display distinct, regional expression patterns that correlate with tRNA expression
Fabres, P. J.; Sai, N.; Pederson, S. M.; Zheng, F.; Breen, J.; Gilliham, M.; Tricker, P. J.; Rodriguez Lopez, C.; David, R.
10.1101/2020.04.13.039131 — plant biology — Posted on 2020-04-13
2825 A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains
van Doremalen, N.; Haddock, E.; Feldmann, F.; Meade-White, K.; Bushmaker, T.; Fischer, R.; Okumura, A.; Hanley, P.; Saturday, G.; Edwards, N.; Clark, M.; Lambe, T.; Gilbert, S.; Munster, V.
10.1101/2020.04.13.036293 — microbiology — Posted on 2020-04-13
2826 An indispensable role for dynamin-related protein 1 (DRP1) in adipogenesis
Mooli, R. G. R.; Mukhi, D.; Chen, Z.; Buckner, N.; Ramakrishnan, S. K.
10.1101/2020.04.13.039149 — cell biology — Posted on 2020-04-13
2833 SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution
Wang, H.; Hou, X.; Wu, X.; Liang, T.; Zhang, X.; Wang, D.; Teng, F.; Dai, J.; Duan, H.; Guo, S.; Li, Y.; Yu, X.
10.1101/2020.03.26.994756 — biochemistry — Posted on 2020-04-13
2835 Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells
Xiong, H.; Wu, Y.; Cao, J.; Yang, R.; Ma, J.; Qiao, X.; Yao, X.; Zhang, B.; Zhang, Y.; Hou, W.; Shi, Y.; Xu, J.; Zhang, L.; Wang, S.; Fu, B.; Yang, T.; Ge, S.; Zhang, J.; Yuan, Q.; Huang, B.; Li, Z.; Zhang, T.; Xia, N.
10.1101/2020.04.08.026948 — microbiology — Posted on 2020-04-13
2836 A phenotype-specific framework for identifying the eye abnormalities causative nonsynonymous-variants
Liu, H.; Dang, X.; Guan, L.; Tian, C.; Zhang, S.; Ye, C.; M. Tellier, L. C. A.; Chen, F.; Yang, H.; Sun, H.; Wu, J.; Zhang, J.
10.1101/2020.04.13.038059 — bioinformatics — Posted on 2020-04-13
2837 Genetic determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo
Foggetti, G.; Li, C.; Cai, H.; Hellyer, J.; Lin, W.-Y.; Ayeni, D.; Hastings, K.; Choi, J.; Wurtz, A.; Andrejka, L.; Maghini, D.; Rashleigh, N.; Levy, S.; Homer, R.; Gettinger, S.; Diehn, M.; Wakelee, H.; Petrov, D.; Winslow, M. M.; Politi, K.
10.1101/2020.04.13.036921 — cancer biology — Posted on 2020-04-13
2839 Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors
Sicari, D.; Pineau, R.; Le Reste, P.-J.; Negroni, L.; Chat, S.; Mohtar, A.; Thomas, D.; Gillet, R.; Hupp, T.; Chevet, E.; Igbaria, A.
10.1101/2020.04.13.038935 — cell biology — Posted on 2020-04-13
2842 Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis
Kwon, O.-S.; Kong, H.-J.; Choi, J.-Y.; Kwon, E.-J.; Kim, Y.-J.; Lee, E.-W.; Kim, W.; Lee, H.; Cha, H.-J.
10.1101/2020.04.13.038430 — systems biology — Posted on 2020-04-13
2844 Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and mice
Zhu, F.; Wang, W.; Ma, Q.; Yang, Z.; Ju, Y.; Fan, Y.; Guo, R.; Wang, Q.; Mu, X.; Zhao, B.; Gao, Y.; He, X.; Gao, F.; Qian, L.; Chen, C.; Chen, Y.; Gao, C.; Ma, X.-c.
10.1101/2020.04.11.021915 — neuroscience — Posted on 2020-04-13
2845 Environment-dependent behavioral traits and experiential factors shape addiction vulnerability
Fouyssac, M.; Puaud, M.; Ducret, E.; Marti-Prats, L.; Vanhille, N.; Ansquer, S.; Zhang, X.; Belin-Rauscent, A.; Giuliano, C.; Houeto, J.-L.; Everitt, B.; Belin, D.
10.1101/2020.04.12.038141 — neuroscience — Posted on 2020-04-13
2848 A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine.
Chauche, C.; Vacca, F.; Chia, S. L.; Richards, J.; Gregory, W. F.; Ogunkanbi, A.; Wear, M.; McSorley, H. J.
10.1101/2020.04.13.035477 — immunology — Posted on 2020-04-13
2850 A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human Relevance
Dudgeon, C.; Harris, C. R.; Chen, Y.; Ghaddar, B.; Sharma, A.; Shah, M. M.; Roberts, A.; Casabianca, A.; Collisson, E.; Balachandran, V.; Vertino, P.; De, S.; Carpizo, D. R.
10.1101/2020.04.13.037374 — cancer biology — Posted on 2020-04-13
2851 Keeping the kids at home can limit the persistence of contagious pathogens in social animals
Marescot, L.; Franz, M.; Benhaiem, S.; Hofer, H.; East, M.; Kramer-Schadt, S.
10.1101/2020.04.11.036806 — ecology — Posted on 2020-04-13
2852 Zirconium(IV)-IMAC for phosphopeptide enrichment in phosphoproteomics
Arribas Diez, I.; Govender, I.; Naicker, P.; Stoychev, S.; Jordaan, J.; Jensen, O. N.
10.1101/2020.04.13.038810 — biochemistry — Posted on 2020-04-13
2853 Cyclopamine sensitizes Glioblastoma cells to Temozolomide treatment through Sonic Hedgehog pathway
Basile Carballo, G.; Matias, D.; Honorato, J.; Santos Pessoa, L.; Neto, A. M. A.; Spohr, T. C. L. d. S. e.
10.1101/2020.04.13.034645 — cancer biology — Posted on 2020-04-13
2854 Scirpy: A Scanpy extension for analyzing single-cell T-cell receptor sequencing data
Sturm, G.; Szabo, T. G.; Fotakis, G.; Haider, M.; Rieder, D.; Trajanoski, Z.; Finotello, F.
10.1101/2020.04.10.035865 — bioinformatics — Posted on 2020-04-13
2856 Histology-Based Average Template of the Marmoset Cortex With Probabilistic Localization of Cytoarchitectural Areas
Majka, P.; Bednarek, S.; Chan, J. M. M.; Jermakow, N.; Liu, C.; Saworska, G.; Worthy, K. H.; Silva, A. C.; Wojcik, D. K.; Rosa, M. G. P.
10.1101/2020.04.10.036632 — neuroscience — Posted on 2020-04-13
2859 Single nucleus sequencing fails to detect microglial activation
Thrupp, N.; Sala Frigerio, C.; Wolfs, L.; Skene, N. G.; Poovathingal, S.; Fourne, Y.; Matthews, P. M.; Theys, T.; Mancuso, R.; de Strooper, B.; Fiers, M.
10.1101/2020.04.13.035386 — neuroscience — Posted on 2020-04-13
2861 Activation of cytoplasmic dynein through microtubule crossbridging
Chakraborty, M.; Toleikis, A.; Siddiqui, N.; Cross, R. A.; Straube, A.
10.1101/2020.04.13.038950 — biophysics — Posted on 2020-04-13
2862 Python nidoviruses, more than respiratory pathogens
Dervas, E.; Hepojoki, J.; Smura, T.; Prähauser, B.; Windbichler, K.; Blumich, S.; Ramis, A.; Hetzel, U.; Kipar, A.
10.1101/2020.04.10.036640 — pathology — Posted on 2020-04-13
2864 A Variable Clock Underlies Internally Generated Hippocampal Sequences
Deng, X.; Chen, S.; Sosa, M.; Karlsson, M. P.; Wei, X.-X.; Frank, L. M.
10.1101/2020.04.10.035980 — neuroscience — Posted on 2020-04-13
2865 Validating the use of bovine buccal sampling as a proxy for the rumen microbiota using a time course and random forest classification approach
Young, J.; Skarlupka, J. H.; Resende, R. T.; Fischer, A.; Kalscheur, K. F.; McClure, J. C.; Cole, J. B.; Suen, G.; Bickhart, D. M.
10.1101/2020.04.10.036665 — microbiology — Posted on 2020-04-13
2868 A platform for brain-wide functional ultrasound imaging and analysis of circuit dynamics in behaving mice
BRUNNER, C.; GRILLET, M.; SANS-DUBLANC, A.; FARROW, K.; LAMBERT, T.; MACE, E.; MONTALDO, G.; URBAN, A.
10.1101/2020.04.10.035436 — neuroscience — Posted on 2020-04-13
2871 Coping with Pleistocene climatic fluctuations: demographic responses in remote endemic reef fishes
Delrieu-Trottin, E.; Hubert, N.; Giles, E. C.; Chifflet-Belle, P.; Suwalski, A.; Neglia, V.; Rapu-Edmunds, C.; Mona, S.; Saenz-Agudelo, P.
10.1101/672774 — genomics — Posted on 2020-04-13
2873 Premature termination codons signal nonsense-mediated gene repair in E. coli
Wang, X.; Wang, X.; Peng, H.; Li, C.; Wang, Y.; Chen, G.; Zhang, J.
10.1101/069971 — genetics — Posted on 2020-04-13
2874 Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits
Mao, T.-R.; Liu, Y.-W.; Meegaskumbura, M.; Yang, J.; Ellepola, G.; Senevirathne, G.; Fu, C.-H.; Gross, J. B.; Pie, M. R.
10.1101/2020.04.12.038034 — evolutionary biology — Posted on 2020-04-13
2879 Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo- derived strain and reveals exceptional intra-specific genetic diversity
Palmateer, N. C.; Tretina, K.; Orvis, J.; Ifeonu, O. O.; Crabtree, J.; Drabek, E.; Pelle, R.; Awino, E.; Gotia, H. T.; Munro, J. B.; Tallon, L.; Morrison, W. I.; Daubenberger, C. A.; Nene, V.; Knowles, D. P.; Bishop, R. P.; Silva, J. C.
10.1101/2020.04.11.037309 — genomics — Posted on 2020-04-13
2881 Single-cell copy number lineage tracing enabling gene discovery
Wang, F.; Wang, Q.; Mohanty, V.; Liang, S.; Dou, J.; Han, J.; Conterno Minussi, D.; Gao, R.; Ding, L.; Navin, N.; Chen, K.
10.1101/2020.04.12.038281 — bioinformatics — Posted on 2020-04-13
2883 DeepRC: Immune repertoire classification with attention-based deep massive multiple instance learning
Widrich, M.; Schäfl, B.; Pavlovic, M.; Sandve, G. K.; Hochreiter, S.; Greiff, V.; Klambauer, G.
10.1101/2020.04.12.038158 — bioinformatics — Posted on 2020-04-13
2885 Microvascular Injury in Mild Traumatic Brain Injury Accelerates Alzheimer-like Pathogenesis in Mice
Wu, Y.; Zeng, J.; Pluimer, B.; Dong, S.; Xie, X.; Guo, X.; Liang, X.; Feng, S.; Wu, H.; Yan, Y.; Chen, J.-F.; Maria, N. S.; Ma, Q.; Gomez-Pinilla, F.; Zhao, Z.
10.1101/2020.04.12.036392 — neuroscience — Posted on 2020-04-13
2887 Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque
Bollimunta, A.; Santacruz, S. R.; Eaton, R. W.; Xu, P. S.; Morrison, J. H.; Moxon, K. A.; Carmena, J. M.; Nassi, J. J.
10.1101/2020.04.10.996116 — neuroscience — Posted on 2020-04-13
2890 PBAP chromatin remodeler mediates enhancer-driven transcription inDrosophila
Shidlovskii, Y. V.; Shaposhnikov, A. V.; Bylino O, O. V.; Amendola, D.; De Simone, G.; Afeltra, N.; Digilio, A. F.; Schedl, P.; Giordano, E.
10.1101/2020.04.11.036772 — genetics — Posted on 2020-04-13
2892 Turning old foes into new allies - harnessing drainage canals for biodiversity conservation in desiccated novel ecosystems
Tolgyesi, C.; Torma, A.; Batori, Z.; Seat, J.; Popovic, M.; Galle, R.; Galle-Szpisjak, N.; Erdos, L.; Vinko, T.; Kelemen, A.; Torok, P.
10.1101/2020.04.11.036897 — ecology — Posted on 2020-04-13
2897 Integrating XMALab and DeepLabCut for high-throughput XROMM
Laurence-Chasen, J. D.; Manafzadeh, A. R.; Hatsopoulos, N.; Ross, C.; Arce-McShane, F.
10.1101/2020.04.10.035949 — animal behavior and cognition — Posted on 2020-04-13
2899 Resistance, resilience, and functional redundancy of freshwater microbial communities facing multiple agricultural stressors in a mesocosm experiment
Barbosa da Costa, N.; Fugere, V.; Hebert, M.-P.; Xu, C. C. Y.; Barrett, R. D. H.; Beisner, B.; Bell, G.; Yargeau, V.; Fussmann, G. F.; Gonzalez, A.; Shapiro, B. J.
10.1101/2020.04.12.038372 — ecology — Posted on 2020-04-13
2906 Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus
Tian, F.; Zhou, F.; Li, X.; Ma, W.; Wu, H.; Yang, M.; Chapman, A. R.; Lee, D. F.; Tan, L.; Xing, D.; Yin, G.; Semayel, A.; Wang, J.; Wang, J.; Sun, W.; He, R.; Zhang, S.; Cao, Z.; Wei, L.; Lu, S.; Yang, D.; Mao, Y.; Gao, Y.; Chen, K.; Zhang, Y.; Liu, X.; Yong, J.; Yan, L.; Huang, Y.; Qiao, J.; Tang, F.; Gao, G.; Xie, X. S.
10.1101/2020.04.12.038000 — genomics — Posted on 2020-04-13
2908 Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits
Mao, T.-R.; Liu, Y.-W.; Meegaskumbura, M.; Yang, J.; Ellepola, G.; Senevirathne, G.; Fu, C.-H.; Gross, J. B.; Pie, M. R.
10.1101/2020.04.12.038034 — evolutionary biology — Posted on 2020-04-13
2909 Interpretable Deep Learning for De Novo Design of Cell-Penetrating Abiotic Polymers
Schissel, C. K.; Mohapatra, S.; Wolfe, J. M.; Fadzen, C. M.; Bellovoda, K.; Wu, C.-L.; Wood, J. A.; Malmberg, A. B.; Loas, A.; Gomez-Bombarelli, R.; Pentelute, B. L.
10.1101/2020.04.10.036566 — bioinformatics — Posted on 2020-04-13
2910 Establishment of a Human Induced Pluripotent Stem Cell-Derived Neuromuscular Co-Culture Under Optogenetic Control
Swartz, E. W.; Shintani, G.; Wan, J.; Maffei, J. S.; Wang, S. H.; Miller, B. L.; Havton, L. A.; Coppola, G.
10.1101/2020.04.10.036400 — neuroscience — Posted on 2020-04-13
2912 Noradrenergic circuits in the forebrain control affective responses to novelty
Lustberg, D.; Tillage, R. P.; Bai, Y.; Pruitt, M.; Liles, L. C.; Weinshenker, D.
10.1101/2020.04.11.037200 — neuroscience — Posted on 2020-04-13
2921 Structural analysis of the PTEN:P-Rex2 signalling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1
D'Andrea, L.; Lucato, C. M.; Marquez, E. A.; Chang, Y.-G.; Civciristov, S.; Huang, C.; Elmlund, H.; Schittenhelm, R. B.; Mitchell, C. A.; Whisstock, J. C.; Halls, M. L.; Ellisdon, A. M.
10.1101/2020.04.11.036434 — biochemistry — Posted on 2020-04-13
2922 Potentials of Aqueous Extract of Bambusa vulgaris to Reactivate β-Cells of Pancreas in Alloxan-Induced Diabetic Wistar Rats
Akiibinu, M.; Ogunleye, S.; Oyekan, I.; Ibikunle, I.; Kolawole, T.; Adesiyan, A.; Anetor, J.; Tayo, F.; Akiibinu, S.
10.1101/2020.04.11.037499 — physiology — Posted on 2020-04-13
2925 Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages
Rensen, E.; Mueller, F.; Scoca, V.; Parmar, J.; Souque, P.; Zimmer, C.; Di Nunzio, F.
10.1101/2020.04.12.038067 — microbiology — Posted on 2020-04-13
2928 Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks
Amimeur, T.; Shaver, J. M.; Ketchem, R. R.; Taylor, J. A.; Clark, R. H.; Smith, J.; Van Citters, D.; Siska, C. C.; Smidt, P.; Sprague, M.; Kerwin, B. A.; Pettit, D.
10.1101/2020.04.12.024844 — immunology — Posted on 2020-04-13
2929 Complete Coding Genome Sequence for a Novel Multicomponent Kindia Tick Virus Detected from Ticks Collected in Guinea
Ternovoi, V. A.; Protopopova, E. V.; Shvalov, A. N.; Kartashov, M. Y.; Bayandin, R. B.; Tregubchak, T. V.; Yakovlev, S. A.; Nikiforov, K. A.; Konovalova, S. N.; Loktev, V.; Agafonov, A. P.; Maksyutov, R. A.; Popova, A. Y.
10.1101/2020.04.11.036723 — genomics — Posted on 2020-04-13
2930 A general model to explain repeated turnovers of sex determination in the Salicaceae
Yang, W.; Zhang, Z.; Wang, D.; Li, Y.; Tong, S.; Li, M.; Zhang, X.; Zhang, L.; Ren, L.; Ma, X.; Zhou, R.; Sanderson, B. J.; Keefover-Ring, K.; Yin, T.; Smart, L. B.; Liu, J.; DiFazio, S. P.; Olson, M.; Ma, T.
10.1101/2020.04.11.037556 — genomics — Posted on 2020-04-13
2932 Vegetation and Microbes Interact to Preserve Organic Matter in Wooded Peatlands
Wang, H.; Tian, J.; Chen, H.; Ho, M.; Vilgalys, R.; Liu, X.; Richardson, C. J.
10.1101/2020.04.11.034108 — ecology — Posted on 2020-04-13
2934 Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability
Barbosa, R.; Xu, A. Q.; D'Andrea, D.; Copley, F.; Patel, H.; Chakravarty, P.; Clear, A.; Calaminici, M.; Janz, M.; Zhang, B.; Schmidt-Supprian, M.; Wang, J.; Gribben, J.; Tooze, R.; Fitzgibbon, J.; Franzoso, G.; Rajewsky, K.; Calado, D. P.
10.1101/2020.04.12.038414 — cancer biology — Posted on 2020-04-13
2935 Crosstalk between microRNA expression and DNA methylation drive the hormone-dependent phenotype of breast cancer
Aure, M. R.; Fleischer, T.; Bjorklund, S.; Ankill, J.; Castro-Mondragon, J. A.; Oslo Breast Cancer Research Consortium (OSBREAC), ; Borresen-Dale, A.-L.; Sahlberg, K. K.; Mathelier, A.; Tekpli, X.; Kristensen, V. N.
10.1101/2020.04.12.038182 — cancer biology — Posted on 2020-04-13
2937 Proteogenomics analysis of non-coding region encoded peptides in normal tissues and five cancer types
Xiang, R.; Ma, L.; Yang, M.; Zheng, Z.; Chen, X.; Jia, F.; Xie, F.; Li, F.; Wu, K.; Zhu, Y.
10.1101/2020.04.10.029306 — bioinformatics — Posted on 2020-04-13
2939 Fonio millet genome unlocks African orphan crop diversity for agriculture in a changing climate
Abrouk, M.; Ahmed, H. I.; CUBRY, P.; Simonikova, D.; Cauet, S.; Bettgenhaeuser, J.; Gapa, L.; Pailles, Y.; Scarcelli, N.; Couderc, M.; Zekraoui, L.; Kathiresan, N.; Cizkova, J.; Hribova, E.; Dolezel, J.; Arribat, S.; Berges, H.; Wieringa, J. J.; Gueye, M.; Kane, N. A.; Leclerc, C.; Causse, S.; Vancoppenolle, S.; Billot, C.; Wicker, T.; Vigouroux, Y.; Barnaud, A.; Krattinger, S. G.
10.1101/2020.04.11.037671 — plant biology — Posted on 2020-04-13
2945 Procentriole microtubules as drivers of centriole reduplication
Vasquez-Limeta, A.; Sullenberger, C.; Kong, D.; Lukasik, K.; Shukla, A.; Loncarek, J.
10.1101/2020.04.12.038307 — cell biology — Posted on 2020-04-13
2950 Adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers
El Alam, M. B.; Sims, T. T.; Kouzy, R.; Biegert, G.; Abi Jaoude, J.; Karpinets, T.; Court, K. Y.; Wu, X.; Medrano, A. D.; Mezzari, M.; Ajami, N.; Solley, T.; Ahmed-Kaddar, M.; Lin, L.; Ramondetta, L.; Jazaeria, A.; Jhingran, A.; Eifel, P.; Schmeler, K.; Wargo, J.; Klopp, A.; Colbert, L.
10.1101/2020.04.10.036426 — cancer biology — Posted on 2020-04-12
2952 Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
Smith, K. H.; Budhraja, A.; Lynch, J.; Roberts, K.; Panetta, J. C.; Connelly, J. P.; Turnis, M. E.; Pruett-Miller, S. M.; Schuetz, J. D.; Mullighan, C.; Opferman, J. T.
10.1101/2020.04.10.036319 — cancer biology — Posted on 2020-04-12
2953 A platform for brain-wide functional ultrasound imaging and analysis of circuit dynamics in behaving mice
BRUNNER, C.; GRILLET, M.; SANS-DUBLANC, A.; FARROW, K.; LAMBERT, T.; MACE, E.; MONTALDO, G.; URBAN, A.
10.1101/2020.04.10.035436 — neuroscience — Posted on 2020-04-12
2954 Isolation, sequence, infectivity and replication kinetics of SARS-CoV-2
Banerjee, A.; Nasir, J. A.; Budylowski, P.; Yip, L.; Aftanas, P.; Christie, N.; Ghalami, A.; Baid, K.; Raphenya, A. R.; Hirota, J. A.; Miller, M. S.; McGeer, A. J.; Ostrowski, M. A.; Kozak, R. A.; McArthur, A. G.; Mossman, K.; Mubareka, S.
10.1101/2020.04.11.037382 — microbiology — Posted on 2020-04-12
2956 MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes
Chelakkot, V. S.; Liu, K.; Yoshioka, E.; Saha, S.; Xu, D.; Licursi, M.; Dorward, A.; Hirasawa, K.
10.1101/2020.04.10.036103 — cancer biology — Posted on 2020-04-12
2958 A New Form of Decellularized Extracellular Matrix Hydrogel for Treating Ischemic Tissue via Intravascular Infusion
Spang, M. T.; Lazerson, T. S.; Bhatia, S.; Corbitt, J.; Sandoval, G.; Luo, C.; Osborn, K. G.; Cabrales, P.; Kwon, E.; Contijoch, F.; Reeves, R. R.; DeMaria, A. N.; Christman, K. L.
10.1101/2020.04.10.028076 — bioengineering — Posted on 2020-04-12
2961 Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins
Peters, C. H.; Myers, M. E.; Juchno, J.; Haimbaugh, C.; Bichraoui, H.; Du, Y.; Bankston, J. R.; Walker, L. A.; Proenza, C.
10.1101/2020.04.10.022483 — physiology — Posted on 2020-04-12
2962 BAG3-dependent autophagy maintains sarcomere function in cardiomyocytes
Martin, T. G.; Myers, V. D.; Dubey, P.; Perez, E.; Morevac, C. S.; Willis, M. S.; Feldman, A. M.; Kirk, J. A.
10.1101/2020.04.10.022319 — physiology — Posted on 2020-04-12
2963 Repurposing a digital kitchen scale for neuroscience research: a complete hardware and software cookbook for PASTA
Virag, D.; Homolak, J.; Kodvanj, I.; Babic Perhoc, A.; Knezovic, A.; Osmanovic Barilar, J.; Salkovic-Petrisic, M.
10.1101/2020.04.10.035766 — neuroscience — Posted on 2020-04-12
2965 Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM
Hopp, C.; Diouf, A.; Miura, K.; Boswell, K.; Sekar, P.; Skinner, J.; Tipton, C. M.; Chambers, M.; Andrews, S.; Tan, J.; Li, S.; Doumbo, S.; Kayentao, K.; Ongoiba, A.; Traore, B.; Portugal, S.; Long, C.; Koup, R. A.; McDermott, A. B.; Crompton, P. D.
10.1101/2020.04.12.030049 — immunology — Posted on 2020-04-12
2966 STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity
Cox, A. R.; Chernis, N.; Bader, D. A.; Saha, P.; Masschelin, P. M.; Felix, J. B.; Lian, Z.; Putluri, V.; Rajapakshe, K.; Kim, K. H.; Villareal, D. T.; Armamento-Villareal, R.; Wu, H.; Coarfa, C.; Putluri, N.; Hartig, S. M.
10.1101/2020.04.10.036053 — immunology — Posted on 2020-04-12
2967 Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease
Wang, Y.-F.; Zhang, Y.; Lin, Z.; Zhang, H.; Wang, T.-Y.; Cao, Y.; Morris, D. L.; Sheng, Y.; Yin, X.; Zhong, S.-L.; Gu, X.; Yao, L.; He, J.; Wu, Q.; Shen, J. J.; Yang, J.; Lam, T.-H.; Lin, J.-H.; Mai, Z.-M.; Guo, M.; Tang, Y.; Chen, Y.; Song, Q.; Ban, B.; Mok, C. C.; Cui, Y.; Lu, L.; Shen, N.; Sham, P. C.; Lau, C. S.; Smith, D. K.; Vyse, T. J.; Zhang, X.; Lau, Y. L.; Yang, W.
10.1101/2020.04.12.037622 — genetics — Posted on 2020-04-12
2969 Visualizing Rev1 Catalyze Protein-template DNA Synthesis
Weaver, T. M.; Cortez, L. M.; Khoang, T. H.; Washington, M. T.; Agarwal, P.; Freudenthal, B. D.
10.1101/2020.04.10.036236 — biochemistry — Posted on 2020-04-12
2970 Mechanistic modeling of the SARS-CoV-2 disease map
Rian, K.; Esteban-Medina, M.; Hidalgo, M. R.; Cubuk, C.; Falco, M. M.; Loucera, C.; Gunyel, D.; Ostaszewski, M.; Pena-Chilet, M.; Dopazo, J.
10.1101/2020.04.12.025577 — systems biology — Posted on 2020-04-12
2971 Sequence, infectivity and replication kinetics of SARS-CoV-2 isolated from COVID-19 patients in Canada
Banerjee, A.; Nasir, J. A.; Budylowski, P.; Yip, L.; Aftanas, P.; Christie, N.; Ghalami, A.; Baid, K.; Raphenya, A. R.; Hirota, J. A.; Miller, M. S.; Ostrowski, M. A.; Kozak, R. A.; McArthur, A. G.; Mossman, K.; Mubareka, S.
10.1101/2020.04.11.037382 — microbiology — Posted on 2020-04-12
2973 Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering
Orapiriyakul, W.; Tsimbouri, M.; Childs, P.; Campsie, P.; Wells, J.; Fernandez, M. M.; Burgess, K.; Tanner, E.; Tassieri, M.; Meek, D.; Vassalli, M.; Biggs, M.; Salmeron-Sanchez, M.; Oreffo, R.; Reid, S.; Dalby, M.
10.1101/2020.04.10.035568 — bioengineering — Posted on 2020-04-12
2976 Enhancer locus in ch14q23.1 modulates brain asymmetric temporal regions involved in language processing
Le Guen, Y.; Leroy, F.; Philippe, C.; IMAGEN Consortium, ; Mangin, J.-F.; Dehaene-Lambertz, G.; Frouin, V.
10.1101/539189 — neuroscience — Posted on 2020-04-12
2979 Changes in the intracranial volume from early adulthood to the sixth decade of life: A longitudinal study
Caspi, Y.; Brouwer, R. M.; Schnack, H. G.; van de Nieuwenhuijzen, M. E.; Cahn, W.; Kahn, R. S.; Niessen, W. J.; van der Lugt, A.; Hulshoff Pol, H.
10.1101/677898 — neuroscience — Posted on 2020-04-12
2980 Abundantly expressed class of non-coding RNAs conserved through the multicellular evolution of dictyostelid social amoebae
Kjellin, J.; Avesson, L.; Reimegard, J.; Liao, Z.; Eichinger, L.; Noegel, A.; Glöckner, G.; Schaap, P.; Söderbom, F.
10.1101/2020.04.05.026054 — evolutionary biology — Posted on 2020-04-12
2981 Mouse Classical and Non-Classical Monocytes Express Comparable Levels of Chemokine Receptor CX3CR1
Cassetta, L.; Heideveld, E.; Matilionyte, G.; Fragkogianni, S.; Van den akker, E.; Kippen, N.; Kitamura, T.; Pollard, J. W.
10.1101/2020.04.10.035550 — immunology — Posted on 2020-04-12
2983 Proteomic analysis of necroptotic extracellular vesicles
Shlomovitz, I.; Yanovich-Arad, G.; Erlich, Z.; Edry-Botzer, L.; Zargarian, S.; Cohen, H.; Ofir-Birin, Y.; Regev-Rudzki, N.; Gerlic, M.
10.1101/2020.04.11.037192 — cell biology — Posted on 2020-04-12
2986 Functional Immune Deficiency Syndrome via Intestinal Infection in COVID-19
Prates, E. T.; Garvin, M. R.; Pavicic, M.; Jones, P.; Shah, M.; Alvarez, C.; Kainer, D.; Demerdash, O.; Amos, B. K.; Geiger, A.; Pestian, J.; Jin, K.; Mitelpunkt, A.; Bardes, E.; Aronow, B.; Jacobson, D.
10.1101/2020.04.06.028712 — systems biology — Posted on 2020-04-12
2988 Optimization of multiplexed CRISPR/Cas9 system for highly efficient genome editing in Setaria viridis
Weiss, T.; Wang, C.; Kang, X.; Zhao, H.; Gamo, M. E.; Starker, C.; Crisp, P. A.; Zhou, P.; Springer, N. M.; Voytas, D.; Zhang, F.
10.1101/2020.04.11.037572 — plant biology — Posted on 2020-04-12
2990 A 21-year survey of from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics, influence local BSI rates, the trends of the B2 phylogroup and the STc131 pandemic clone
Rodriguez, I.; Figueiredo, A. S.; Sousa, M.; Lanza, V. F.; Rodriguez, C.; Mingo, P.; Zamora, J.; Loza, E.; Brooks, C. J.; Canton, R.; Baquero, F.; Coque, T. M.
10.1101/2020.04.10.034777 — microbiology — Posted on 2020-04-12
2991 Short-chain fatty acid production by gut microbiota from children with obesity is linked to bacterial community composition and prebiotic choice
Holmes, Z. C.; Silverman, J. D.; Dressman, H. K.; Wei, Z.; Dallow, E. P.; Armstrong, S. C.; Seed, P. C.; Rawls, J. F.; David, L. A.
10.1101/2020.04.10.035808 — microbiology — Posted on 2020-04-12
2993 Proliferation control of kidney interstitial cells
McCarthy, S. S.; Gower, L.; Karolak, M. J.; Fessler, A.; Carroll, T. J.; Oxburgh, L.
10.1101/2020.04.11.037259 — developmental biology — Posted on 2020-04-12
2994 Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis
Ferreira, A. P. A.; Casamento, A.; Carrillo Roas, S.; Panambalana, J.; Subramaniam, S.; Schuetzenhofer, K.; Halff, E. F.; Cha Wah Hak, L.; McGourty, K.; Kittler, J.; Thalassinos, K.; Martinvalet, D.; Boucrot, E.
10.1101/2020.04.11.036863 — cell biology — Posted on 2020-04-12
2997 Precise, high-throughput production of multicellular spheroids with a bespoke 3D bioprinter
Utama, R. H.; Atapattu, L.; O'Mahony, A. P.; Fife, C. M.; Baek, J.; Allard, T.; O'Mahony, K. J.; Ribeiro, J.; Gaus, K.; Kavallaris, M.; Gooding, J.
10.1101/2020.04.06.028548 — bioengineering — Posted on 2020-04-12
3000 Characterization of essential eggshell proteins from Aedes aegypti mosquitoes
Simington, C. J.; Oscherwitz, M. E.; Peterson, A. J.; Rascon, A. A.; Massani, B. B.; Miesfeld, R.; ISOE, J.
10.1101/2020.04.06.027706 — developmental biology — Posted on 2020-04-12
3005 SEQUIN multiscale imaging of mammalian central synapses reveals loss of synaptic microconnectivity resulting from diffuse traumatic brain injury
Sauerbeck, A. D.; Gangolli, M.; Reitz, S. J.; Salyards, M. H.; Kim, S. H.; Hemingway, C.; Makkapati, T.; Kerschensteiner, M.; Brody, D. L.; Kummer, T. T.
10.1101/704916 — neuroscience — Posted on 2020-04-11
3006 Comparison of SARS-CoV-2 infections among 3 species of non-human primates
Lu, S.; Zhao, Y.; Yu, W.; Yang, Y.; Gao, J.; Wang, J.; Kuang, D.; Yang, M.; Yang, J.; Ma, C.; Xu, J.; Li, H.; Zhao, S.; Li, J.; Wang, H.; Long, H.; Zhou, J.; Luo, F.; Ding, K.; Wu, D.; Zhang, Y.; Dong, Y.; Liu, Y.; Zheng, Y.; Lin, X.; Jiao, L.; Zheng, H.; Dai, Q.; Sun, Q.; Hu, Y.; Ke, C.; Liu, H.; Peng, X.
10.1101/2020.04.08.031807 — microbiology — Posted on 2020-04-12
3007 The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement
Quinlan, B. D.; Mou, H.; Zhang, L.; Gao, Y.; He, W.; Ojha, A.; Parcells, M. S.; Luo, G.; Li, W.; Zhong, G.; Choe, H.; Farzan, M.
10.1101/2020.04.10.036418 — microbiology — Posted on 2020-04-12
3008 Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
Aguiar, J. A.; Tremblay, B. J.-M.; Mansfield, M. J.; Woody, O.; Lobb, B.; Banerjee, A.; Chandiramohan, A.; Tiessen, N.; Dvorkin-Gheva, A.; Revill, S.; Miller, M. S.; Carlsten, C.; Organ, L.; Joseph, C.; John, A.; Hanson, P. J.; McManus, B. M.; Jenkins, G.; Mossman, K.; Ask, K.; Doxey, A. C.; Hirota, J. A.
10.1101/2020.04.07.030742 — immunology — Posted on 2020-04-12
3009 IFN-{lambda}4 is associated with increased risk and earlier occurrence of gastrointestinal, respiratory and malarial infections in Malian children
Prokunina-Olsson, L.; Morrison, R. L.; Obajemu, A.; Mahamar, A.; Kim, S.; Attaher, O.; Florez-Vargas, O.; Sidibe, Y.; Onabajo, O. O.; Hutchinson, A. A.; Manning, M.; Kwan, J.; Brand, N.; Dicko, A.; Fried, M.; Albert, P. S.; Mbulaiteye, S. M.; Duffy, P. E.
10.1101/2020.02.24.962688 — genetics — Posted on 2020-04-12
3010 Eukaryotic-like ribosomal RNA in Asgard archaea
Penev, P. I.; Fakhretaha-Aval, S.; Patel, V. J.; Cannone, J. J.; Gutell, R. R.; Petrov, A. S.; Williams, L. D.; Glass, J. B.
10.1101/2019.12.25.888164 — evolutionary biology — Posted on 2020-04-12
3011 Analysis of Ten Microsecond simulation data of SARS-CoV-2 dimeric main protease
Parves, R.; Riza, Y.; Mahmud, S.; Islam, R.; Ahmed, S.; Evy, B. A.; Hasan, H.; Halim, M. A.
10.1101/2020.04.10.036020 — bioinformatics — Posted on 2020-04-12
3018 The missing role of gray matter in studying brain controllability
Jamalabadi, H.; Zuberer, A.; Kumar, V. J.; Li, M.; Alizadeh, S.; Moradi, A. A.; Gaser, C.; Esterman, M.; Walter, M.
10.1101/2020.04.07.030015 — neuroscience — Posted on 2020-04-11
3020 SARS-CoV-2 detection with CRISPR diagnostics
Guo, L.; Sun, X.; Wang, X.; Liang, C.; Jiang, H.; Gao, Q.; Dai, M.; Qu, B.; Fang, S.; Mao, Y.; Chen, Y.; Feng, G.; Gu, Q.; Wang, L.; Wang, R. R.; Zhou, Q.; Li, W.
10.1101/2020.04.10.023358 — molecular biology — Posted on 2020-04-11
3021 Evaluation of heating and chemical protocols for inactivating SARS-CoV-2
Pastorino, B.; Touret, F.; Gilles, M.; de Lamballerie, X.; Charrel, R. N.
10.1101/2020.04.11.036855 — microbiology — Posted on 2020-04-11
3025 Mouse Classical and Non-Classical Monocytes Express Comparable Levels of Chemokine Receptor CX3CR1
Cassetta, L.; Heideveld, E.; Matilionyte, G.; Fragkogianni, S.; Van den akker, E.; Kippen, N.; Kitamura, T.; Pollard, J. W.
10.1101/2020.04.10.035550 — immunology — Posted on 2020-04-11
3026 Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling
Lo, A.; Holmes, K.; Mundt, F.; Moorthi, S.; Fung, I.; Fereshetian, S.; Watson, J.; Carr, S. A.; Mertins, P.; Berger, A.
10.1101/2020.04.10.030460 — cancer biology — Posted on 2020-04-11
3027 CREBBP/EP300 mutation is associated with poor outcome in HNSCC and targetable with synthetic cytotoxicity.
Kumar, M.; Molkentine, D.; Molkentine, J.; Bridges, K.; Xie, T.; Yang, L.; Gao, M.; Frederick, M. J.; Seth, S.; Abdelhakiem, M.; Johnson, F. M.; Wang, J.; Shen, L.; Heffernan, T.; Sheth, A.; Ferris, R.; Myers, J. N.; Pickering, C. R.; Skinner, H. D.
10.1101/2020.04.10.028217 — cancer biology — Posted on 2020-04-11
3028 Morphology and Blood Metabolites Reflect Recent Spatial Differences Among Lake Winnipeg Walleye, Sander vitreus
Thorstensen, M. J.; Wiens, L. M.; Jeffrey, J. D.; Klein, G. M.; Jeffries, K. M.; Treberg, J. R.
10.1101/2020.04.10.035832 — physiology — Posted on 2020-04-11
3029 Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis
Fournier, A. P.; Baudron, E.; Wagnon, I.; Aubert, P.; Vivien, D.; Neunlist, M.; Bardou, I.; Docagne, F.
10.1101/2020.04.10.033662 — neuroscience — Posted on 2020-04-11
3031 Omics integration analyses reveal the early evolution of malignancy in breast cancer
Sarhadi, S.; Salehzadeh-Yazdi, A.; Damaghi, M.; Zarghami, N.; Wolkenhauer, O.; Hosseini, H.
10.1101/2020.04.09.033845 — evolutionary biology — Posted on 2020-04-11
3033 Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering
Oripiriyakul, W.; Tsimbouri, M.; Childs, P.; Campsie, P.; Wells, J.; Fernandez, M. M.; Burgess, K.; Tanner, E.; Tassieri, M.; Meek, D.; Vassalli, M.; Biggs, M.; Salmeron-Sanchez, M.; Oreffo, R.; Reid, S.; Dalby, M.
10.1101/2020.04.10.035568 — bioengineering — Posted on 2020-04-11
3035 Acoustic regularities in infant-directed vocalizations across cultures
Moser, C. J.; Lee-Rubin, H.; Bainbridge, C. M.; Atwood, S.; Simson, J.; Knox, D.; Glowacki, L.; Galbarczyk, A.; Jasienska, G.; Ross, C.; Neff, M. B.; Martin, A.; Cirelli, L. K.; Trehub, S. E.; Song, J.; Kim, M.; Schachner, A.; Vardy, T. A.; Atkinson, Q. D.; Antfolk, J.; Madhivanan, P.; Siddaiah, A.; Placek, C. D.; Salali, G. D.; Keestra, S.; Singh, M.; Collins, S. A.; Patton, J. Q.; Scaff, C.; Stieglitz, J.; Moya, C.; Sagar, R. R.; Wood, B. M.; Krasnow, M. M.; Mehr, S. A.
10.1101/2020.04.09.032995 — animal behavior and cognition — Posted on 2020-04-11
3049 Isolated Nuclei Stiffen in Response to Low Intensity Vibration
Newberg, J. K.; Schimpf, J.; Woods, K.; Davis, P. H.; Uzer, G.
10.1101/2020.04.09.034546 — bioengineering — Posted on 2020-04-11
3056 The Development of Cognitive Control in Children with Autism Spectrum Disorders or Obsessive-Compulsive Disorder: A Longitudinal fMRI study
Gooskens, B.; Bos, D. J.; Naaijen, J.; Akkermans, S. E. A.; Kaiser, A.; Hohmann, S.; Bruchhage, M. M. K.; Banaschewski, T.; Brandeis, D.; Williams, S. C. R.; Lythgoe, D. J.; Buitelaar, J. K.; Oranje, B.; Durston, S.; the TACTICS consortium,
10.1101/2020.04.09.033696 — neuroscience — Posted on 2020-04-11
3057 Discovery and characterisation of novel circular bacteriocin plantacyclin B21AG from Lactobacillus plantarum B21
Golneshin, A.; Gor, M. C.; Vezina, B.; Williamson, N.; Van, T. T. H.; May, B. K.; Smith, A. T.
10.1101/2020.04.10.035774 — biochemistry — Posted on 2020-04-11
3058 A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity
Ganley, J. G.; Pandey, A.; Sylvester, K.; Lu, K.-Y.; Toro Moreno, M.; Rutschlin, S.; Bradford, J. M.; Champion, C. J.; Bottcher, T.; Xu, J.; Derbyshire, E. R.
10.1101/2020.04.09.034280 — microbiology — Posted on 2020-04-11
3061 HSPs, Ubiquitins and Antioxidants aid in Heat Tolerance in Tharparkar Indicine cattle
Khan, R. I. N.; Sahu, A. R.; Malla, W. A.; Praharaj, M. R.; Hosamani, N.; Kumar, S.; Gupta, S.; Sharma, S.; Saxena, A.; Varshney, A.; Singh, P.; Verma, V.; Kumar, P.; Singh, G.; Pandey, A.; Saxena, S.; Gandham, R. K.; Tiwari, A. K.
10.1101/2020.04.09.031153 — physiology — Posted on 2020-04-11
3063 Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis.
Hurlstone, A. F.; Bottiglione, F.; Dee, C. T.; Lea, R.; Zeef, L.; Badrock, A. P.; Wane, M.; Bugeon, L.; Dallman, M. J.; Allen, J. E.
10.1101/2020.04.09.033837 — immunology — Posted on 2020-04-11
3064 Selection and gene flow define polygenic barriers between incipient butterfly species
Van Belleghem, S. M.; Cole, J. M.; Montejo Kovacevich, G.; Bacquet, C. N.; McMillan, W. O.; Papa, R.; Counterman, B. A.
10.1101/2020.04.09.034470 — evolutionary biology — Posted on 2020-04-11
3065 LADON, a natural antisense transcript of NODAL, promotes metastasis in melanoma by repressing NDRG1
Dutriaux, A.; Diazzi, S.; Caburet, S.; Bresesti, C.; Hardouin, S.; Deshayes, F.; Collignon, J.; Flagiello, D.
10.1101/2020.04.09.032375 — cancer biology — Posted on 2020-04-11
3066 Substrate binding modulates the conformational kinetics of the secondary multidrug transporter LmrP
Roth, A.; Martens, C.; van Oene, T.; Barth, A.; Wanninger, S.; Lamb, D. C.; Hendrix, J.; Govaerts, C.
10.1101/2020.04.09.034439 — biophysics — Posted on 2020-04-11
3067 Kill and cure: genomic phylogeny and bioactivity of a diverse collection of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles
Jones, C.; Webster, G.; Mullins, A. J.; Jenner, M.; Bull, M. J.; Dashti, Y.; Spilker, T.; Parkhill, J.; Connor, T. R.; LiPuma, J. J.; Challis, G. L.; Mahenthiralingam, E.
10.1101/2020.04.09.033878 — microbiology — Posted on 2020-04-11
3069 Impaired HSF1 transactivation drives proteostasis collapse and senescent phenotype of IPF lung fibroblast.
Cuevas-Mora, K.; Roque, W.; Sales, D.; Ritzenthaler, J. D.; Torres-Gonzales, E.; Halayko, A. J.; Rosas, I. O.; Roman, J.; Romero, F.
10.1101/2020.04.10.036327 — cell biology — Posted on 2020-04-11
3071 Identification of a Micropeptide on Lipid Droplet That Mediates Lipid Storage and Insulin Sensitivity
Huang, T.; Bamigbade, A. T.; Xu, S.; Deng, Y.; Xie, K.; Ogunsade, O. O.; Mirza, A. H.; Wang, J.; Liu, P.; Zhang, S.
10.1101/2020.04.10.036160 — cell biology — Posted on 2020-04-11
3075 Daily mitochondrial dynamics in cone photoreceptors
Giarmarco, M. M.; Brock, D. C.; Robbings, B. M.; Cleghorn, W. M.; Tsantilas, K. A.; Kuch, K. C.; Ge, W.; Rutter, K. M.; Parker, E. D.; Brockerhoff, S. E.
10.1101/2020.04.10.030262 — cell biology — Posted on 2020-04-11
3076 Quantify the requirements to achieve grain Zn biofortification of high-yield wheat on calcareous soils
Wang, S.; Wang, Z.; Li, S.; Diao, C.; Liu, L.; Huang, N.; Huang, M.; Hui, X.; Luo, L.; He, G.; Cao, H.
10.1101/2020.04.09.033639 — plant biology — Posted on 2020-04-11
3077 XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition
Sharma, A. B.; Erasimus, H.; Pinto, L.; Caron, M.-C.; Neumann, K.; Nazarov, P. V.; Klink, B.; Fritah, S.; Herold-Mende, C. C.; Niclou, S. P.; Calsou, P.; Masson, J.-Y.; Britton, S.; Van Dyck, E.
10.1101/2020.04.10.035410 — molecular biology — Posted on 2020-04-11
3079 The development of a novel diagnostic PCR for Madurella mycetomatis using a comparative genome approach
Lim, W.; Eadie, K.; Siddig, E. E.; Nyuykonge, B.; Ahmed, S.; Fahal, A.; Verbon, A.; Smit, S.; van de Sande, W. W. J.
10.1101/2020.04.10.036681 — microbiology — Posted on 2020-04-11
3080 A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasis
Zhou, C.; Monin, L.; Gordon, R.; Aggor, F. E.; Bechara, R.; Edwards, T.; Kaplan, D. H.; Gingras, S.; gaffen, s.
10.1101/2020.04.09.028027 — immunology — Posted on 2020-04-11
3081 Immune factor of bacterial origin protects ticks against host microbial commensals
Hayes, B. M.; Radkov, A. D.; Yarza, F.; Flores, S.; Kim, J. R.; Zhao, Z.; Lexa, K. W.; Marnin, L.; Biboy, J.; Bowcutt, V.; Vollmer, W.; Pedra, J. H.; Chou, S.
10.1101/2020.04.10.036376 — evolutionary biology — Posted on 2020-04-11
3084 In-depth Bioinformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles
Bartas, M.; Brazda, V.; Bohalova, N.; Cantara, A.; Volna, A.; Stachurova, T.; Malachova, K.; Jagelska, E. B.; Porubiakova, O.; Cerven, J.; Pecinka, P.
10.1101/2020.04.09.031252 — bioinformatics — Posted on 2020-04-11
3085 Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: a computational biology approach
Lokman, S. M.; Rasheduzzaman, M.; Salauddin, A.; Barua, R.; Tanzina, A. Y.; Rumi, M. H.; Hossain, M. I.; Siddiki, A. Z.; Mannan, A.; Hasan, M. M.
10.1101/2020.04.07.030924 — bioinformatics — Posted on 2020-04-11
3091 Comparative ACE2 variation and primate COVID-19 risk
Melin, A. D.; Janiak, M. C.; Marrone, F.; Arora, P. S.; Higham, J. P.
10.1101/2020.04.09.034967 — genetics — Posted on 2020-04-11
3092 Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses
Hognon, C.; Miclot, T.; Garcia Iriepa, C.; France-Monerris, A.; Grandemange, S.; Terenzi, A.; Marazzi, M.; Barone, G.; Monari, A.
10.1101/2020.04.07.029447 — biophysics — Posted on 2020-04-10
3094 Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging
Qian, Y.; Cosio, D. M. O.; Piatkevich, K. D.; Aufmkolk, S.; Su, W.-C.; Celiker, O. T.; Schohl, A.; Murdock, M. H.; Aggarwal, A.; Chang, Y.-F.; Wiseman, P. W.; Ruthazer, E. S.; Boyden, E. S.; Campbell, R. E.
10.1101/2020.04.08.032433 — molecular biology — Posted on 2020-04-10
3096 Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium
Sajuthi, S. P.; DeFord, P.; Jackson, N. D.; Montgomery, M. T.; Everman, J. L.; Rios, C. L.; Pruesse, E.; Nolin, J. D.; Plender, E. G.; Wechsler, M. E.; Mak, A. C.; Eng, C.; Salazar, S.; Medina, V.; Wohlford, E. M.; Huntsman, S.; Nickerson, D. A.; Germer, S.; Zody, M. C.; Abecasis, G.; Kang, H. M.; Rice, K. M.; Kumar, R.; Oh, S.; Rodriguez-Santana, J.; Burchard, E. G.; Seibold, M. A.
10.1101/2020.04.09.034454 — genomics — Posted on 2020-04-10
3097 Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation
Wang, C.; Duan, Y.; Duan, G.; Ma, Z.; Zhang, K.; Deng, X.; Qian, B.; Gu, J.; Wang, Q.; Zhang, S.; Guo, L.; Liu, C.; Fang, Y.
10.1101/802058 — neuroscience — Posted on 2020-04-10
3098 Alzheimer's disease brain-derived tau-containing extracellular vesicles: Pathobiology and GABAergic neuronal transmission
Ruan, Z.; Pathak, D.; Kalavai, S. V.; Yoshii-Kitahara, A.; Muraoka, S.; Takamatsu-Yukawa, K.; Hu, J.; Wang, Y.; Hersh, S.; Gorantla, S.; Kayed, R.; Gendelman, H.; Ikezu, S.; Luebke, J. I.; Ikezu, T.
10.1101/2020.03.15.992719 — neuroscience — Posted on 2020-04-10
3101 Structural and functional analysis of a potent sarbecovirus neutralizing antibody
Pinto, D.; Park, Y.-J.; Beltramello, M.; Walls, A. C.; Tortorici, M. A.; Bianchi, S.; Jaconi, S.; Culap, K.; Zatta, F.; De Marco, A.; Peter, A.; Guarino, B.; Spreafico, R.; Cameroni, E.; Case, J. B.; Chen, R. E.; Havenar-Daughton, C.; Snell, G.; Telenti, A.; Virgin, H. W.; Lanzavecchia, A.; Diamond, M. S.; Fink, K.; Veesler, D.; Corti, D.
10.1101/2020.04.07.023903 — immunology — Posted on 2020-04-10
3102 The evolution of red colour vision is linked to coordinated rhodopsin tuning in lycaenid butterflies
Lienard, M. A.; Bernard, G. D.; Allen, A. A.; Lassance, J.-M.; Song, S.; Rabideau Childers, R. A.; Yu, N.; Ye, D.; Stephenson, A.; Valencia Montoya, W. A.; Salzman, S.; Whitaker, M. R.; Calonje, M.; Zhang, F.; Pierce, N. E.
10.1101/2020.04.06.027102 — evolutionary biology — Posted on 2020-04-10
3103 Confronting the COVID-19 Pandemic with Systems Biology
Prates, E. T.; Garvin, M. R.; Pavicic, M.; Jones, P.; Shah, M.; Alvarez, C.; Kainer, D.; Demerdash, O.; Amos, B. K.; Geiger, A.; Pestian, J.; Jin, K.; Mitelpunkt, A.; Bardes, E.; Aronow, B.; Jacobson, D.
10.1101/2020.04.06.028712 — systems biology — Posted on 2020-04-10
3104 Modelling and rescue of RP2 Retinitis Pigmentosa using iPSC Derived Retinal Organoids
Lane, A.; Jovanovic, K.; Shortall, C.; Ottaviani, D.; Brugulat-Panes, A.; Schwarz, N.; Guarascio, R.; Hayes, M. J.; Palfi, A.; Chadderton, N.; Farrar, G. J.; Hardcastle, A. J.; Cheetham, M. E.
10.1101/2020.01.28.923227 — neuroscience — Posted on 2020-04-10
3107 ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.
Surface, L. E.; Burrow, D. T.; Li, J.; Kumar, S.; Park, J.; Lyu, C.; Song, N.; Yu, Z.; Rajagopal, A.; Bae, Y.; Lee, B. H.; Mumm, S.; Gu, C. C.; Wan, F.; Baker, J. C.; Mohseni, M.; Sum, M.; Huskey, M.; Duan, S.; Bijanki, V. N.; Civitelli, R.; Gardner, M. J.; McAndrew, C. M.; Ricci, W. M.; Gurnett, C. A.; Diemer, K.; Shannon, K. M.; Raje, N.; Dodson, T. B.; Costantino, C. L.; Haber, D. A.; Carette, J. E.; Varadarajan, M.; Brummelkamp, T. R.; Birsoy, K.; Sabatini, D. M.; Haller, G.; Peterson, T. R.
10.1101/338350 — genomics — Posted on 2020-04-10
3108 Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19
Han, L.; Wei, X.; Liu, C.; Volpe, G.; Wang, Z.; Pan, T.; Yuan, Y.; Lei, Y.; Lai, Y.; Ward, C.; Yu, Y.; Wang, M.; Shi, Q.; Wu, T.; Wu, L.; Liu, Y.; Wang, C.; Zhang, Y.; Sun, H.; Yu, H.; Zhuang, Z.; Tang, T.; Huang, Y.; Lu, H.; Xu, L.; Xu, J.; Cheng, M.; Liu, Y.; Wong, C. W.; Tan, T.; Ji, W.; Maxwell, P. H.; Yang, H.; Wang, J.; Zhu, S.; Liu, S.; Xu, X.; Hou, Y.; Esteban, M. A.; Liu, L.
10.1101/2020.04.10.022103 — cell biology — Posted on 2020-04-10
3109 Evaluating the transcriptional fidelity of cancer models
Peng, D.; Gleyzer, R.; Tai, W.-H.; Kumar, P.; Bian, Q.; Issacs, B.; Lummertz da Rocha, E.; Cai, S.; DiNapoli, K.; Huang, F.; Cahan, P.
10.1101/2020.03.27.012757 — cancer biology — Posted on 2020-04-10
3114 Cells and gene expression programs in the adult human heart
Litvinukova, M.; Talavera-Lopez, C.; Maatz, H.; Reichart, D.; Worth, C. L.; Lindberg, E. L.; Kanda, M.; Polanski, K.; Fasouli, E. S.; Samari, S.; Roberts, K.; Tuck, E.; Heinig, M.; DeLaughter, D.; McDonough, B.; Wakimoto, H.; Gorham, J. M.; Nadelmann, E.; Mahbubani, K. T.; Saeb-Parsy, K.; Patone, G.; Boyle, J. J.; Zhang, H.; Zhang, H.; Viveiros, A.; Oudit, G.; Bayraktar, O.; Seidman, J. G.; Seidman, C.; Noseda, M.; Hubner, N.; Teichmann, S. A.
10.1101/2020.04.03.024075 — genomics — Posted on 2020-04-10
3115 Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility
Stawiski, E. W.; Diwanji, D.; Suryamohan, K.; Gupta, R.; Fellouse, F. A.; Sathirapongsasuti, F.; Liu, J.; Jiang, Y.-P.; Ratan, A.; Mis, M.; Santhosh, D.; Somasekar, S.; Mohan, S.; Phalke, S.; Kuriakose, B.; Antony, A.; Junutula, J. R.; Schuster, S. C.; Jura, N.; Seshagiri, S.
10.1101/2020.04.07.024752 — genetics — Posted on 2020-04-10
3122 Monolingual and bilingual infants rely on the same brain networks: Evidence from resting-state functional connectivity
Blanco, B.; Molnar, M.; Carreiras, M.; Collins-Jones, L. H.; Vidal, E.; Cooper, R. J.; Caballero-Gaudes, C.
10.1101/2020.04.10.035469 — neuroscience — Posted on 2020-04-10
3124 A High-Resolution In Vivo Atlas of the Human Brain's Benzodiazepine Binding Site of GABAA Receptors
Norgaard, M.; Beliveau, V.; Ganz, M.; Svarer, C.; Pinborg, L. H.; Keller, S. H.; Jensen, P. S.; Greve, D. N.; Knudsen, G. M.
10.1101/2020.04.10.035352 — neuroscience — Posted on 2020-04-10
3126 Adaptive evolution of olfactory degeneration in recently flightless insects
Neupert, S.; McCulloch, G. A.; Foster, B. J.; Waters, J. M.; Szyszka, P.
10.1101/2020.04.10.035311 — neuroscience — Posted on 2020-04-10
3127 Single-neuron models linking electrophysiology, morphology and transcriptomics across cortical cell types
Nandi, A.; Chartrand, T.; Van Geit, W.; Buchin, A.; Yao, Z.; Lee, S. Y.; Wei, Y.; Kalmbach, B.; Lee, B.; Lein, E.; Berg, J.; Sumbul, U.; Koch, C.; Tasic, B.; Anastassiou, C. A.
10.1101/2020.04.09.030239 — neuroscience — Posted on 2020-04-10
3128 PKD promotes activity-dependent AMPA receptorendocytosis in hippocampal neurons
Oueslati Morales, C. O.; Ignacz, A.; Bencsik, N.; Ratkai, A. E.; Lieb, W. S.; Eisler, S. A.; Schlett, K.; Hausser, A.
10.1101/2020.04.09.033514 — neuroscience — Posted on 2020-04-10
3132 FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing
Hennion, M.; Arbona, J.-M.; Lacroix, L.; Cruaud, C.; Theulot, B.; Le Tallec, B.; Proux, F.; Wu, X.; Novikova, E.; Engelen, S.; Lemainque, A.; Audit, B.; Hyrien, O.
10.1101/2020.04.09.033720 — genomics — Posted on 2020-04-10
3140 MYB5a/NEGAN activates petal anthocyanin pigmentation and shapes the MBW regulatory network in Mimulus luteusvar. variegatus
Zheng, X.; Om, K.; Stanton, K. A.; Thomas, D.; Cheng, P. A.; Eggert, A.; Yuan, Y.-W.; Puzey, J. R.; Cooley, A. M.
10.1101/2020.04.09.030536 — genetics — Posted on 2020-04-10
3141 Deaf intermarriage does not increase the prevalence of deafness alleles
Braun, D. C.; Greenwald, B. H.; Jain, S.; Epstein, E.; Herold, B.; Gray, M.
10.1101/2020.04.09.034728 — genetics — Posted on 2020-04-10
3143 Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis
Ola, M.; O'Brien, C. E.; Coughlan, A. Y.; Ma, Q.; Donovan, P. D.; Wolfe, K. H.; Butler, G.
10.1101/2020.04.09.034512 — genomics — Posted on 2020-04-10
3147 Calcitriol increases frataxin levels and restores altered markers in cell models of Friedreich Ataxia
Britti, E.; Delaspre, F.; Medina-Carbonero, M.; Sanz, A.; Llovera, M.; Purroy, R.; Mincheva-Tasheva, S.; Tamarit, J.; ROS, J.
10.1101/2020.04.09.034017 — biochemistry — Posted on 2020-04-10
3148 Furin controls β cell function via mTORC1 signaling
Brouwers, B.; Coppola, I.; Vints, K.; Dislich, B.; Jouvet, N.; Van Lommel, L.; Gounko, N. V.; Thorrez, L.; Schuit, F.; Lichtenthaler, S. F.; Estall, J. L.; Declercq, J.; Ramos-Molina, B.; Creemers, J. W. M.
10.1101/2020.04.09.027839 — physiology — Posted on 2020-04-10
3151 High glucose attenuates Ca2+ influx in cytotoxic T lymphocytes upon target recognition
Zou, H.; Schwaer, G.; Zhao, R.; Alansary, D.; Yin, D.; Schwarz, E. C.; Niemeyer, B.; Qu, B.
10.1101/2020.04.09.028019 — immunology — Posted on 2020-04-10
3152 DIVA: natural navigation inside 3D images usingvirtual reality
El Beheiry, M.; Godard, C.; Caporal, C.; Marcon, V.; Ostertag, C.; Sliti, O.; Doutreligne, S.; Fournier, S.; Hajj, B.; Dahan, M.; Masson, J.-B.
10.1101/2020.04.09.019935 — bioinformatics — Posted on 2020-04-10
3153 A new set of composite, non-redundant electroencephalogram measures of non-rapid eye movement sleep based on the power law scaling of the Fourier spectrum
Bodizs, R.; Szalardy, O.; Horvath, C.; Peter, U. P.; Gombos, F.; Simor, P.; Potari, A.; Zeising, M.; Steiger, A.; Dresler, M.
10.1101/2020.04.09.035113 — neuroscience — Posted on 2020-04-10
3154 MARCH8 inhibits viral infection by two different mechanisms
Zhang, Y.; Tada, T.; Ozono, S.; Kishigami, S.; Fujita, H.; Tokunaga, K.
10.1101/2020.04.09.035204 — microbiology — Posted on 2020-04-10
3155 Dynamics of viral index infections in novel hosts
Mollentze, N.; Streicker, D. G.; Murcia, P. R.; Hampson, K.; Biek, R.
10.1101/2020.04.09.033928 — ecology — Posted on 2020-04-10
3158 The impact of di-2-ethylhexyl phthalate on sperm fertility
Gabelev Khasin, L.; Dell Rosa, J.; Petersen, N.; Moeller, J.; Kriegsfeld, L. J.; Lishko, P. V.
10.1101/2020.04.09.034835 — pharmacology and toxicology — Posted on 2020-04-10
3168 Biosynthetic gene clusters, secondary metabolite profiles, and cards of virulence in the closest nonpathogenic relatives of Aspergillus fumigatus
Steenwyk, J. L.; Mead, M. E.; Knowles, S. L.; Raja, H. A.; Roberts, C. D.; Bader, O.; Houbraken, J.; Goldman, G. H.; Oberlies, N. H.; Rokas, A.
10.1101/2020.04.09.033902 — evolutionary biology — Posted on 2020-04-10
3170 The Molecular Landscape of Asian Breast Cancers Reveals Clinically Relevant Population-Specific Differences
Pan, J.-W.; Ahmad Zabidi, M. M.; Ng, P.-S.; Meng, M.-Y.; Hasan, S. N.; Sandey, B.; Sammut, S. J.; Yip, C.-H.; Rajadurai, P.; Rueda, O. M.; Caldas, C.; Chin, S.-F.; Teo, S.-H.
10.1101/2020.04.09.035055 — cancer biology — Posted on 2020-04-10
3171 High-throughput AFM analysis reveals unwrapping pathways of H3 and CENP-A nucleosomes
Konrad, S. F.; Vanderlinden, W.; Frederickx, W.; Brouns, T.; Menze, B.; De Feyter, S.; Lipfert, J.
10.1101/2020.04.09.034090 — biophysics — Posted on 2020-04-10
3174 The effect of device configuration and patient body composition on image artifact and RF heating of deep brain stimulation devices during MRI at 1.5T and 3T
Bhusal, B.; Nguyen, B. T.; Vu, J.; Elahi, B.; Rosenow, J.; Nolt, M. J.; Lopez-Rosado, R.; Pilitsis, J.; DiMarzio, M.; Golestani Rad, L.
10.1101/2020.04.09.035030 — bioengineering — Posted on 2020-04-10
3178 Differential protein phosphorylation affects the localisation of two secreted Toxoplasma proteins and is widespread during stage conversion
Young, J.; Broncel, M.; Teague, H.; Russell, M. R.; McGovern, O.; Renshaw, M.; Frith, D.; Snijders, A. P.; Collinson, L. M.; Carruthers, V. B.; Ewald, S. E.; Treeck, M.
10.1101/2020.04.09.035279 — microbiology — Posted on 2020-04-10
3180 Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia
Bachireddy, P.; Ennis, C.; Nguyen, V.; Clement, K.; Gohil, S. H.; Shukla, S. A.; Forman, J.; Barkas, N.; Freeman, S.; Bavli, N.; Elagina, L.; Leshchiner, I.; Mohammad, A. W.; Rassenti, L. Z.; Kipps, T. J.; Brown, J. R.; Getz, G. A.; Ho, V. T.; Gnirke, A.; Neuberg, D.; Soiffer, R. J.; Ritz, J.; Alyea, E. P.; Kharchenko, P. V.; Wu, C. J.
10.1101/2020.04.09.033555 — cancer biology — Posted on 2020-04-10
3188 Altered hypothalamic DNA methylation and stress-induced hyperactivity in a novel model of early life stress
Fitzgerald, E.; Sinton, M. C.; Wernig-Zorc, S.; Morton, N. M.; Holmes, M. C.; Boardman, J. P.; Drake, A. J.
10.1101/2020.04.09.033951 — developmental biology — Posted on 2020-04-10
3190 The regulation of a pigmentation gene in the formation of complex color patterns in Drosophila abdomens
Raja, K. K. B.; Shittu, M. O.; Nouhan, P. M. E.; Steenwinkel, T. E.; Bachman, E. A.; Kokate, P. P.; McQueeney, A. H.; Mundell, E. A.; Armentrout, A. A.; Peabody, A. M.; Werner, T.
10.1101/2020.04.09.034900 — developmental biology — Posted on 2020-04-10
3191 In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1
Kernan, J.; Martinez-Chacin, R. C.; Wang, X.; Tiedemann, R. L.; Bonacci, T.; Choudhury, R.; Bolhuis, D.; Damrauer, J. S.; Yan, F.; Harrison, J. S.; Major, M. B.; Hoadley, K.; Suzuki, A.; Rothbart, S. B.; Brown, N. G.; Emanuele, M. J.
10.1101/2020.04.09.033621 — cell biology — Posted on 2020-04-10
3193 Structural Insight into Mitochondrial Beta-Barrel Outer Membrane Protein Biogenesis
Diederichs, K. A.; Ni, X.; Rollauer, S. E.; Botos, I.; Tan, X.; King, M. S.; Kunji, E. R.; Jiang, J.; Buchanan, S. K.
10.1101/2020.04.09.034678 — biochemistry — Posted on 2020-04-10
3197 Transcriptome analysis of the zebrafish atoh7-/- mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases
Covello, G.; Rossello, F. J.; Filosi, M.; Gajardo, F.; Duchemin, A.-L.; Tremonti, B. F.; Eichenlaub, M.; Polo, J. M.; Powell, D.; Ngai, J.; Allende, M. L.; Domenici, E.; Ramialison, M.; Poggi, L.
10.1101/2020.04.09.033704 — developmental biology — Posted on 2020-04-10
3198 A role for the autophagic receptor, SQSTM1/p62, in trafficking NF-kB/RelA to nucleolar aggresomes
Lobb, I. T.; Morin, P.; Martin, K. J.; Lleshi, X.; Olsen, K.; Duncan, R. R.; Stark, L. A.
10.1101/2020.04.09.034975 — cell biology — Posted on 2020-04-10
3199 The Ephrin receptor A2 and Roundabout Guidance Receptor 1 heterodimer: A potential theranostic for squamous cell carcinomas
Pang, K. M.; Srivastava, S.; Iida, M.; Nelson, M.; Liu, J.; Nam, A.; Wang, J.; Mambetsariev, I.; Mohanty, A.; McDaniel, N.; Behal, A.; Kulkarni, P.; Wheeler, D. L.; Salgia, R.
10.1101/2020.04.09.034405 — cancer biology — Posted on 2020-04-10
3202 The 3.2A resolution structure of human mTORC2
Scaiola, A.; Mangia, F.; Imseng, S.; Boehringer, D.; Berneiser, K.; Shimobayashi, M.; Stuttfeld, E.; Hall, M. N.; Ban, N.; Maier, T.
10.1101/2020.04.10.029835 — biochemistry — Posted on 2020-04-10
3203 Differential regulation of the immune system in a brain-liver-fats organ network during short term fasting
Huang, S. S.; Makhlouf, M.; AbouMoussa, E. H.; Ruiz Tejada Segura, M. L.; Mathew, L. S.; Wang, K.; Leung, M. C.; Chaussabel, D.; Logan, D. W.; Scialdone, A.; Garand, M.; Saraiva, L. R.
10.1101/2020.04.05.026351 — systems biology — Posted on 2020-04-10
3204 Post-translational polymodification of β1 tubulin regulates motor protein localisation in platelet production and function
Khan, A. O.; Slater, A.; Maclachlan, A.; Nicolson, P. L.; Pike, J. A.; Reyat, J. S. S.; Yule, J.; Stapley, R.; Thomas, S. G.; Morgan, N. V.
10.1101/595868 — cell biology — Posted on 2020-04-10
3208 Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors
Valle-Casuso, j.-c.; Gaudaire, D.; Martin-Faivre, L.; madeline, a.; Dallemagne, P.; Pronost, S.; Munier-Lehmann, H.; Zientara, S.; Vidalain, P.-O.; Hans, A.
10.1101/2020.04.10.035402 — microbiology — Posted on 2020-04-10
3210 Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures
Smith, E. H.; Merricks, E. M.; Liou, J.-y.; Casadei, C.; Melloni, L.; Thesen, T.; Friedman, D.; Doyle, W.; Emerson, R. G.; Goodman, R.; McKhann, G. M.; Sheth, S.; Rolston, J. D.; Schevon, C.
10.1101/2020.04.07.030205 — physiology — Posted on 2020-04-10
3211 M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's Disease
Fernandez-Garcia, S.; Conde-Berriozabal, S.; Garcia-Garcia, E.; Gort-Paniello, C.; Bernal-Casas, D.; Garcia-Diaz Barriga, G.; Lopez-Gil, J.; Munoz-Moreno, E.; Soria, G.; Campa, L.; Artigas, F.; Rodriguez, M. J.; Alberch, J.; Masana, M.
10.1101/2020.04.08.032359 — neuroscience — Posted on 2020-04-10
3212 Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
Yin, W.; Mao, C.; Luan, X.; Shen, D.-D.; Shen, Q.; Su, H.; Wang, X.; Zhou, F.; Zhao, W.; Gao, M.; Chang, S.; Xie, Y.-C.; Tian, G.; Jiang, H.-W.; Tao, S.-C.; Shen, J.; Jiang, Y.; Jiang, H.; Xu, Y.; Zhang, S.; Zhang, Y.; Xu, H. E.
10.1101/2020.04.08.032763 — molecular biology — Posted on 2020-04-10
3214 A new model for vertebrate mineralization via stabilized amorphous calcium carbonate for avian eggshell formation
Stapane, L.; Le Roy, N.; Ezagal, J.; Rodriguez-Navarro, A. B.; Labas, V.; Combes-Soia, L.; Hincke, M. T.; Gautron, J.
10.1101/2020.04.08.031989 — biochemistry — Posted on 2020-04-10
3215 MgrA regulates interaction of Staphylococcus aureus with mucin
Parker, C. P.; Akil, N.; Shanrock, C. R.; Allen, P. D.; Chaly, A. L.; Crosby, H.; Kwiecinski, J.; Horswill, A. R.; Fischer, A. J.
10.1101/2020.04.09.035261 — microbiology — Posted on 2020-04-10
3218 20-Hydroxyecdysone activates the protective arm of the renin angiotensin system via Mas receptor
Lafont, R.; Raynal, S.; Serova, M.; Didry-Barca, B.; Guibout, L.; Latil, M.; Dilda, P. J.; Dioh, W.; Veillet, S.
10.1101/2020.04.08.032607 — cell biology — Posted on 2020-04-10
3219 Analysis of new nosological models from disease similarities using clustering
Prieto Santamaria, L.; Garcia del Valle, E. P.; Lagunes Garcia, G.; Zanin, M.; Rodriguez Gonzalez, A.; Menasalvas Ruiz, E.; Perez Gallardo, Y.; Hernandez Chan, G. S.
10.1101/2020.04.10.035394 — bioinformatics — Posted on 2020-04-10
3224 Quantify the requirements to achieve grain Zn biofortification of high-yield wheat on calcareous soils
Wang, S.; Wang, Z.; Li, S.; Diao, C.; Liu, L.; Huang, N.; Huang, M.; Hui, X.; Luo, L.; He, G.; Cao, H.
10.1101/2020.04.09.033639 — plant biology — Posted on 2020-04-10
3226 Pattern-recognition receptors are required for NLR-mediated plant immunity
Yuan, M.; Jiang, Z.; Bi, G.; Nomura, K.; Liu, M.; He, S. Y.; Zhou, J.-M.; Xin, X.-F.
10.1101/2020.04.10.031294 — plant biology — Posted on 2020-04-10
3228 Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1
Morgernstern, J.; Katz, S.; Krebs-Haupenthal, J.; Chen, J.; Saadatmand, A.; Garcia Cortizo, F.; Moraru, A.; Zemva, J.; Campos, M. C.; Teleman, A. A.; Backs, J.; Nawroth, P. P.; Fleming, T.
10.1101/2020.04.09.033159 — molecular biology — Posted on 2020-04-10
3229 Optimization of SARS-CoV-2 detection by RT-QPCR without RNA extraction
Merindol, N.; Pepin, G.; Marchand, C.; Rheault, M.; Peterson, C.; Poirier, A.; Germain, H.; Danylo, A.
10.1101/2020.04.06.028902 — molecular biology — Posted on 2020-04-10
3230 Bacterial DNAemia is associated with serum zonulin levels in older subjects
Gargari, G.; Taverniti, V.; Del Bo, C.; Berardi, S.; Andres-Lacueva, C.; Gonzalez-Dominguez, R.; Kroon, P. A.; Winterbone, M. S.; Cherubini, A.; Riso, P.; Guglielmetti, S.
10.1101/2020.04.10.035519 — microbiology — Posted on 2020-04-10
3232 Characterization of the oral microbiome of medically controlled type-2 diabetes patients
Santos, A.; Martins-Mendes, D.; Gaya-Vidal, M.; Perez-Pardal, L.; Beja-Pereira, A.
10.1101/2020.04.07.031070 — microbiology — Posted on 2020-04-10
3233 The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation
Minns, D.; Smith, K. J.; Alessandrini, V.; Hardisty, G.; Melrose, L.; Jackson-Jones, L. H.; MacDonald, A. S.; Davidson, D. J.; Gwyer Findlay, E.
10.1101/2020.04.10.035543 — immunology — Posted on 2020-04-10
3234 Innovation, conservation and repurposing of gene function in plant root cell type development
Kajala, K.; Shaar-Moshe, L.; Mason, G. A.; Gouran, M.; Rodriguez-Medina, J.; Kawa, D.; Pauluzzi, G.; Reynoso, M.; Canto-Pastor, A.; Lau, V.; Artur, M. A. S.; West, D. A.; Manzano, C.; Gray, S. B.; Yao, A. I.; Bajic, M.; Formentin, E.; Nirmal, N.; Rodriguez, A.; Pasha, A.; Borowsky, A. T.; Deal, R.; Kliebenstein, D. J.; Hvidsten, T. R.; Provart, N. J.; Sinha, N. R.; Runcie, D. E.; Bailey-Serres, J.; Brady, S.
10.1101/2020.04.09.017285 — genomics — Posted on 2020-04-10
3241 BioLaboro: A bioinformatics system for detecting molecular assay signature erosion and designing new assays in response to emerging and reemerging pathogens
Holland, M.; Negron, D.; Mitchell, S.; Dellinger, N.; Ivancich, M.; Barrus, T.; Thomas, S.; Jennings, K. W.; Goodwin, B. G.; Sozhamannan, S.
10.1101/2020.04.08.031963 — bioinformatics — Posted on 2020-04-10
3242 Comparative secretome of Magnaporthe oryzae identified proteins involved in virulence and cell wall integrity
Liu, N.; Qi, L.; Huang, M.; Chen, D.; Yin, C.; Zhang, Y.; Wang, X.; Yuan, G.; Wang, R.-J.; Yang, J.; Peng, Y.-L.; Lu, X.
10.1101/2020.04.10.035139 — plant biology — Posted on 2020-04-10
3245 Using real-time fluorescence and deformability cytometry and deep learning to transfer molecular specificity to label-free sorting
Nawaz, A. A.; Urbanska, M.; Herbig, M.; Nötzel, M.; Kräter, M.; Rosendahl, P.; Herold, C.; Toepfner, N.; Kubankova, M.; Goswami, R.; Abuhattum, S.; Reichel, F.; Müller, P.; Taubenberger, A. V.; Girardo, S.; Jacobi, A.; Guck, J.
10.1101/862227 — biophysics — Posted on 2020-04-10
3247 Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy
Xin, J.; Li, Y.; Liu, H.-X.; Li, J.; Yang, G.; Zhang, H.; Wang, J.; Tong, R.; Wei, D.; Yao, Y.-F.
10.1101/2020.04.05.026252 — biophysics — Posted on 2020-04-10
3248 β-arrestin-dependent ERK signaling positively correlates with reduced anxiety-like and conditioned fear-related behavior in mice
Ko, M. J.; Chiang, T.; Mukadam, A. A.; Mulia, G. E.; Gutridge, A. M.; Lin, A.; Chester, j. A.; van Rijn, R. M.
10.1101/790568 — neuroscience — Posted on 2020-04-10
3251 ID4 represses myoepithelial differentiation of mammary stem cells through its interaction with HEB
Holliday, H.; Roden, D. L.; Junankar, S.; Wu, S. Z.; Baker, L. A.; Krisp, C.; Chan, C.-L.; McFarland, A.; Skhinas, J. N.; Cox, T. R.; Pal, B.; Huntington, N.; Ormandy, C. J.; Carroll, J.; Visvader, J.; Molloy, M. P.; Swarbrick, A.
10.1101/2020.04.06.026963 — developmental biology — Posted on 2020-04-10
3252 Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria
Decio, P.; Ustaoglu, P.; Derecka, K.; Scocchia, D.; Hardy, I.; Roat, T.; Malaspina, O.; Mongan, N.; Stoger, R.; Soller, M.
10.1101/853291 — pharmacology and toxicology — Posted on 2020-04-09
3256 Bitbow: a digital format of Brainbow enables highly efficient neuronal lineage tracing and morphology reconstruction in single brains
Li, Y.; Walker, L. A.; Zhao, Y.; Edwards, E. M.; Michki, N. S.; Cheng, H. P. J.; Ghazzi, M.; Chen, T. Y.; Chen, M.; Roossien, D. H.; Cai, D.
10.1101/2020.04.07.030593 — neuroscience — Posted on 2020-04-09
3258 From iron to antibiotics: Identification of conserved bacterial-fungal interactions across diverse partners
Pierce, E. C.; Morin, M.; Little, J. C.; Liu, R. B.; Tannous, J.; Keller, N. P.; Wolfe, B. E.; Pogliano, K.; Sanchez, L. M.; Dutton, R. J.
10.1101/2020.03.19.999193 — microbiology — Posted on 2020-04-09
3267 Active Vision in Immersive, 360° Real-World Environments
Haskins, A. J.; Mentch, J.; Botch, T. L.; Robertson, C. E.
10.1101/2020.03.05.976712 — neuroscience — Posted on 2020-04-09
3270 IDseq - An Open Source Cloud-based Pipeline and Analysis Service for Metagenomic Pathogen Detection and Monitoring
Kalantar, K. L.; Carvalho, T.; de Bourcy, C. F. A.; Dimitrov, B.; Dingle, G.; Egger, R.; Han, J.; Holmes, O. B.; Juan, Y.-F.; King, R.; Kislyuk, A.; Mariano, M.; Reynoso, L. V.; Rissato Cruz, D.; Sheu, J.; Tang, J.; Wang, J.; Zhang, M. A.; Zhong, E.; Ahyong, V.; Lay, S.; Chea, S.; Bohl, J. A.; Manning, J. E.; Tato, C. M.; DeRisi, J. L.
10.1101/2020.04.07.030551 — bioinformatics — Posted on 2020-04-09
3272 Regulation of light harvesting in Chlamydomonas: two protein phosphatases are involved in state transitions
Cariti, F.; Chazaux, M.; Legendre-Lefebvre, L.; Longoni, P.; Ghysels, B.; Johnson, X.; Goldschmidt-Clermont, M.
10.1101/2020.03.31.018721 — plant biology — Posted on 2020-04-09
3274 A randomized, double blind study of computerized cognitive training in combination with transcranial direct current stimulation in stroke patients - utility of fMRI as marker for training outcome
Kolskaar, K. K.; Richard, G.; Alnaes, D.; Dorum, E. S.; Sanders, A.-M.; Ulrichsen, K. M.; Monereo Sanchez, J.; Ihle-Hansen, H.; Nordvik, J. E.; Westlye, L. T.
10.1101/603985 — neuroscience — Posted on 2020-04-09
3276 Reliability of single-subject neural activation patterns across speech production tasks
Frankford, S. A.; Nieto-Castanon, A.; Tourville, J. A.; Guenther, F. H.
10.1101/807925 — neuroscience — Posted on 2020-04-09
3277 The physiological level of rNMPs present in mtDNA does not compromise its stability
Wanrooij, P. H.; Tran, P.; Thompson, L. J.; Sharma, S.; Kreisel, K.; Navarrete, C.; Feldberg, A.-L.; Watt, D.; Nilsson, A. K.; Engqvist, M. K.; Clausen, A. R.; Chabes, A.
10.1101/746719 — molecular biology — Posted on 2020-04-09
3278 Trait-based approach to bacterial growth efficiency
Muscarella, M. E.; Howey, X. M.; Lennon, J. T.
10.1101/427161 — microbiology — Posted on 2020-04-09
3280 Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells
Xiong, H.; Wu, Y.; Cao, J.; Yang, R.; Ma, J.; Qiao, X.; Yao, X.; Zhang, B.; Zhang, Y.; Hou, W.; Shi, Y.; Xu, J.; Zhang, L.; Wang, S.; Fu, B.; Yang, T.; Ge, S.; Zhang, J.; Yuan, Q.; Huang, B.; Li, Z.; Zhang, T.; Xia, N.
10.1101/2020.04.08.026948 — microbiology — Posted on 2020-04-09
3281 Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses
Auslander, N.; Gussow, A. B.; Faure, G.; Wolf, Y. I.; Zhang, F.; Koonin, E. V.
10.1101/2020.04.05.026450 — microbiology — Posted on 2020-04-09
3285 FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue and PPARγ specific regulation: a transcriptome analysis
Toth, B. B.; Arianti, R.; Shaw, A.; Vamos, A.; Vereb, Z.; Poliska, S.; Gyory, F.; Bacso, Z.; Fesus, L.; Kristof, E.
10.1101/2020.02.21.959593 — cell biology — Posted on 2020-04-09
3286 Knowledge Beacons: Web Service Workflow for FAIR Data Harvesting of Distributed Biomedical Knowledge
Hannestad, L. M.; Dancik, V.; Suen, I. W.; Godden, M.; Huellas-Bruskiewicz, K. C.; Good, B. M.; Mungall, C. J.; Bruskiewich, R. M.
10.1101/2020.04.06.027425 — bioinformatics — Posted on 2020-04-09
3288 CytoPy: an autonomous cytometry analysis framework
Burton, R. J.; Ahmed, R.; Cuff, S.; Artemiou, A.; Eberl, M.
10.1101/2020.04.08.031898 — bioinformatics — Posted on 2020-04-09
3299 Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
Yin, W.; Mao, C.; Luan, X.; Shen, D.-D.; Shen, Q.; Su, H.; Wang, X.; Zhou, F.; Zhao, W.; Gao, M.; Chang, S.; Xie, y.; Tian, G.; Jiang, J.; Tao, S.-c.; shen, j.; Jiang, Y.; Jiang, h.; Xu, Y.; Zhang, S.; Zhang, Y.; Xu, H. E.
10.1101/2020.04.08.032763 — molecular biology — Posted on 2020-04-09
3301 Structural basis for the inhibition of COVID-19 virus main protease by carmofur, an antineoplastic drug
Jin, Z.; Zhao, Y.; Sun, Y.; Zhang, B.; Wang, H.; Wu, Y.; Zhu, Y.; Zhu, C.; Hu, T.; Du, X.; Duan, Y.; Yu, J.; Yang, X.; Yang, X.; Liu, X.; Guddat, L. W.; Xiao, G.; Zhang, L.; Yang, H.; Rao, Z.
10.1101/2020.04.09.033233 — biochemistry — Posted on 2020-04-09
3302 Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
Brann, D.; Tsukahara, T.; Weinreb, C.; Lipovsek, M.; Van den Berge, K.; Gong, B.; Chance, R.; Macaulay, I. C.; Chou, H.-j.; Fletcher, R.; Das, D.; Street, K.; Roux de Bezieux, H.; Choi, Y.-G.; Risso, D.; Dudoit, S.; Purdom, E.; Mill, J. C.; Hachem, R. A.; Matsunami, H.; Logan, D. W.; Goldstein, B.; Grubb, M. S.; Ngai, J.; Datta, S. R.
10.1101/2020.03.25.009084 — neuroscience — Posted on 2020-04-09
3304 Structural analysis of SARS-CoV-2 and predictions of the human interactome
Vandelli, A.; Monti, M.; Milanetti, E.; Delli Ponti, R.; Tartaglia, G. G.
10.1101/2020.03.28.013789 — bioinformatics — Posted on 2020-04-09
3305 SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution
Wang, H.; Hou, X.; Wu, X.; Liang, T.; Zhang, X.; Wang, D.; Teng, F.; Dai, J.; Duan, H.; Guo, S.; Li, Y.; Yu, X.
10.1101/2020.03.26.994756 — biochemistry — Posted on 2020-04-09
3307 SARS-CoV-2 sensitive to type I interferon pretreatment.
Lokugamage, K. G.; Hage, A.; Schindewolf, C.; Rajsbaum, R.; Menachery, V. D.
10.1101/2020.03.07.982264 — microbiology — Posted on 2020-04-09
3308 Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
Gao, Y.; Yan, L.; Huang, Y.; Liu, F.; Zhao, Y.; Cao, L.; Wang, T.; Sun, Q.; Ming, Z.; Zhang, L.; Ge, J.; Zheng, L.; Zhang, Y.; Wang, H.; Zhu, Y.; Zhu, C.; Hu, T.; Hua, T.; Zhang, B.; Yang, X.; Li, J.; Yang, H.; Liu, Z.; Xu, W.; Guddat, L. W.; Wang, Q.; Lou, Z.; Rao, Z.
10.1101/2020.03.16.993386 — biochemistry — Posted on 2020-04-09
3315 Room-temperature-storable PCR Mixes for SARS-CoV-2 Detection
Xu, J.; Wang, J.; Zhong, Z.; Su, X.; Yang, K.; Chen, Z.; Zhang, D.; Li, T.; Wang, Y.; Zhang, S.; Ge, S.; Zhang, J.; Xia, N.
10.1101/2020.04.07.029934 — microbiology — Posted on 2020-04-09
3318 Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
Aguiar, J. A.; Tremblay, B. J.-M.; Mansfield, M. J.; Woody, O.; Lobb, B.; Banerjee, A.; Chandiramohan, A.; Tiessen, N.; Dvorkin-Gheva, A.; Revill, S.; Miller, M. S.; Carlsten, C.; Organ, L.; Joseph, C.; John, A.; Jenkins, G.; Mossman, K.; Ask, K.; Doxey, A. C.; Hirota, J. A.
10.1101/2020.04.07.030742 — immunology — Posted on 2020-04-09
3319 Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis
Guo, C.; Li, B.; Ma, H.; Wang, X.; Cai, P.; Yu, Q.; Zhu, L.; Jin, L.; Jiang, C.; Fang, J.; Liu, Q.; Zong, D.; Zhang, W.; Lu, Y.; Li, K.; Gao, X.; Fu, B.; Liu, L.; Ma, X.; Weng, J.; Wei, H.; Jin, T.; Lin, J.; Qu, K.
10.1101/2020.04.08.029769 — genomics — Posted on 2020-04-09
3322 Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19
Xing, J.; Shankar, R.; Drelich, A.; Paithankar, S.; Chekalin, E.; Dexheimer, T.; Rajasekaran, S.; Tseng, C.-T. K.; Chen, B.
10.1101/2020.04.07.030734 — genomics — Posted on 2020-04-09
3323 Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro
Pan, X.; Zhou, P.; Fan, T.; Wu, Y.; Zhang, J.; Shi, X.; Shang, W.; Fang, L.; Jiang, X.; Shi, J.; Sun, Y.; Zhao, S.; Gong, R.; Chen, Z.; Xiao, G.
10.1101/2020.04.07.029884 — pharmacology and toxicology — Posted on 2020-04-09
3324 Mate discrimination among subspecies through a conserved olfactory pathway
Khallaf, M. A.; Auer, T. O.; Grabe, V.; Depetris-Chauvin, A.; Ammagarahalli, B.; Zhang, D.-D.; Lavista-Llanos, S.; Kaftan, F.; Weissflog, J.; Matzkin, L. M.; Rollmann, S.; Loefstedt, C.; Svatos, A.; Dweck, H. K.; Sachse, S.; Benton, R.; Hansson, B. S.; Knaden, M.
10.1101/854364 — neuroscience — Posted on 2020-04-09
3330 Activity-dependent translation in astrocytes
Sapkota, D.; Sakers, K.; Liu, Y.; Lake, A. M.; Khazanchi, R.; Khankan, R. R.; Zhang, Y.; Dougherty, J. D.
10.1101/2020.04.08.033027 — neuroscience — Posted on 2020-04-09
3331 Genetically targeted reporter imaging of deep neuronal network in the mammalian brain
Shimojo, M.; Ono, M.; Takuwa, H.; Mimura, K.; Nagai, Y.; Fujinaga, M.; Kikuchi, T.; Okada, M.; Seki, C.; Tokunaga, M.; Maeda, J.; Takado, Y.; Takahashi, M.; Minamihisamatsu, T.; Zhang, M.-R.; Tomita, Y.; Suzuki, N.; Maximov, A.; Suhara, T.; Minamimoto, T.; Sahara, N.; Higuchi, M.
10.1101/2020.04.08.032870 — neuroscience — Posted on 2020-04-09
3333 Cortical Hierarchy and The Dual Counterstream Architecture.
Vezoli, J.; Magrou, L.; Wang, X.-J.; Knoblauch, K.; Vinck, M.; Kennedy, H.
10.1101/2020.04.08.032706 — neuroscience — Posted on 2020-04-09
3335 Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging
Qian, Y.; Cosio, D. M. O.; Piatkevich, K. D.; Aufmkolk, S.; Su, W.-C.; Celike, O. T.; Schohl, A.; Murdock, M. H.; Aggarwal, A.; Chang, Y.-F.; Wiseman, P. W.; Ruthazer, E. S.; Boyden, E. S.; Campbell, R. E.
10.1101/2020.04.08.032433 — molecular biology — Posted on 2020-04-09
3337 ArlCDE form the archaeal switch complex
Li, Z.; Rodriguez-Franco, M.; Albers, S.-V.; Quax, T. E. F.
10.1101/2020.04.09.033365 — microbiology — Posted on 2020-04-09
3338 JAK1 inhibition blocks lethal sterile immune responses:implications for COVID-19 therapy
Tuttle, K.; Minter, R.; Waugh, K.; Araya, P.; Ludwig, M.; Sempeck, C.; Smith, K.; Andrysik, Z.; Burchill, M.; Tamburini, B.; Orlicky, D.; Sullivan, K. D.; Espinosa, J.
10.1101/2020.04.07.024455 — immunology — Posted on 2020-04-09
3343 Structural features of an infectious recombinant PrPSc prion using solid state NMR
Martin-Pastor, M.; Codeseira, Y. B.; Spagnolli, G.; Erana, H.; Fernandez, L. C.; Bravo, S.; Iglesias, A.; Lopez-Moreno, R.; Veiga, S.; Biasini, E.; Sanchez-Pedregal, V. M.; Castilla, J.; Requena, J. R.
10.1101/2020.04.08.032839 — biochemistry — Posted on 2020-04-09
3348 Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis
Redl, E.; Sheibani-Tezerji, R.; Hamminger, P.; Timelthaler, G.; Hassler, M. R.; Lagger, S.; Dillinger, T.; Hofbauer, L.; Zrimsek, M.; Tiefenbacher, A.; Kothmayer, M.; Dietz, C. H.; Ramsahoye, B. H.; Kenner, L.; Bock, C.; Seiser, C.; Ellmeier, W.; Schweikert, G.; Egger, G.
10.1101/2020.04.09.033373 — cancer biology — Posted on 2020-04-09
3349 User-friendly, scalable tools and workflows for single-cell analysis
Moreno, P.; Huang, N.; Manning, J. R.; Mohammed, S.; Solovyev, A.; Polanski, K.; Chazarra, R.; Talavera-Lopez, C. A.; Doyle, M.; Marnier, G.; Gruening, B. A.; Rasche, H.; Bacon, W.; Perez-Riverol, Y.; Haeussler, M.; Meyer, K. B.; Teichmann, S.; Papatheodorou, I.
10.1101/2020.04.08.032698 — bioinformatics — Posted on 2020-04-09
3351 Complete and validated genomes from a metagenome
Giguere, D. J.; Bahcheli, A. T.; Joris, B. R.; Paulssen, J. M.; Gieg, L. M.; Flatley, M. W.; Gloor, G. B.
10.1101/2020.04.08.032540 — bioinformatics — Posted on 2020-04-09
3354 Microrheology reveals microscale viscosity gradients in planktonic systems
Guadayol, O.; Mendonca, T.; Segura-Noguera, M.; Wright, A. J.; Tassieri, M.; Humphries, S.
10.1101/2020.04.09.033464 — ecology — Posted on 2020-04-09
3356 MS-CleanR: A feature-filtering approach to improve annotation rate in untargeted LC-MS based metabolomics
Fraisier-Vannier, O.; Chervin, J.; Cabanac, G.; Puech-Pages, V.; Fournier, S.; Durand, V.; Amiel, A.; Andre, O.; Benamar, O. A.; Dumas, B.; Tsugawa, H.; Marti, G.
10.1101/2020.04.09.033308 — bioinformatics — Posted on 2020-04-09
3357 Assessments of hepatitis B virus-like particles and Crm197 as carrier proteins in melioidosis glycoconjugate vaccines
Bayliss, M.; Pergolizzi, G.; Donaldson, M. I.; Scott, A. E.; Nepogodiev, S. A.; Beales, L.; Whelan, M.; Rosenberg, W.; Peyret, H.; Lomonossoff, G. P.; Harmer, N. J.; Atkins, T.; Field, R. A.; Prior, J. L.
10.1101/2020.04.08.031658 — immunology — Posted on 2020-04-09
3359 Accurate imputation of histone modifications using transcription
Wang, Z.; Chivu, A. G.; Choate, L. A.; Rice, E. J.; Miller, D. C.; Chu, T.; Chou, S.-P.; Kingsley, N. B.; Peterson, J. L.; Finno, C. J.; Bellone, R. R.; Antczak, D. F.; Danko, C. G.
10.1101/2020.04.08.032730 — genomics — Posted on 2020-04-09
3360 Whole-genome analysis of noncoding genetic variations identifies multigranular regulatory element perturbations associated with Hirschsprung disease
Fu, A. X.; Lui, K. N.-C.; Tang, C. S.-M.; Ng, R. K.; Lai, F. P.-L.; Lau, S.-T.; Li, Z.; Gracia-Barcelo, M.-M.; Sham, P.; Tam, P. K.-H.; Ngan, E. S.-W.; Yip, K. Y.
10.1101/2020.04.08.032045 — genetics — Posted on 2020-04-09
3363 5' modifications to CRISPR Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage
Mullally, G.; van Aelst, K.; Naqvi, M. M.; Diffin, F. M.; Karvelis, T.; Gasiunas, G.; Siksnys, V.; Szczelkun, M. D.
10.1101/2020.04.09.033399 — biochemistry — Posted on 2020-04-09
3364 A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
Martinelli, P.; Kloesch, B.; Hruschka, N.; Ionasz, V.; Oellinger, R.; Mueller, S.; Martinez de Villareal, J.; Dienes, H. P.; Schindl, M.; Gruber, E.; Stift, J.; Lomberk, G. A.; Seidler, B.; Saur, D.; Rad, R.; Urrutia, R. A.; Real, F. X.
10.1101/2020.04.09.033456 — cancer biology — Posted on 2020-04-09
3365 The effect of recombination on the evolution of a population of Neisseria meningitidis
MacAlasdair, N.; Pesonen, M.; Brynildsrud, O.; Eldholm, V.; Kristiansen, P. A.; Corander, J.; Caugant, D. A.; Bentley, S. D.
10.1101/2020.04.08.031906 — evolutionary biology — Posted on 2020-04-09
3368 Repeated parallel losses of inflexed stamens in Moraceae: phylogenomics and generic revision of the tribe Moreae and the reinstatement of the tribe Olmedieae (Moraceae)
Gardner, E. M.; Garner, M.; Cowan, R.; Dodsworth, S.; Epitawalage, N.; Maurin, O.; Arifiani, D.; Sahromi, S.; Baker, W. J.; Forest, F.; Zerega, N. J.; Monro, A. K.; Hipp, A. L.
10.1101/2020.04.08.030452 — plant biology — Posted on 2020-04-09
3374 Poly(ADP-ribose) induces α-synuclein aggregation in neuronal-like cells andinteracts with phosphorylated α-synuclein in post mortem PD samples
Puentes, L. N.; Lengyel-Zhand, Z.; Lee, J. Y.; Hsieh, C.-J.; Schneider, M. E.; Edwards, K. J.; Luk, K. C.; Lee, V. M.- Y.; Trojanowski, J. Q.; Mach, R. H.
10.1101/2020.04.08.032250 — neuroscience — Posted on 2020-04-09
3375 Metabolic differences between symbiont subpopulations in the deep-sea tubeworm Riftia pachyptila
Hinzke, T.; Kleiner, M.; Meister, M.; Schlueter, R.; Hentschker, C.; Pane-Farre, J.; Hildebrandt, P.; Felbeck, H.; Sievert, S. M.; Bonn, F.; Voelker, U.; Becher, D.; Schweder, T.; Markert, S.
10.1101/2020.04.08.032177 — microbiology — Posted on 2020-04-09
3376 Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication
Borrmann, H.; Davies, R.; Dickinson, M.; Pedroza-Pacheco, I.; Schilling, M.; Vaughan-Jackson, A.; James, W.; Balfe, P.; Borrow, P.; McKeating, J. A.; Zhuang, X.
10.1101/2020.04.09.031492 — microbiology — Posted on 2020-04-09
3380 An approach for normalization and quality control for NanoString RNA expression data
Bhattacharya, A.; Hamilton, A. M.; Furberg, H.; Pietzak, E.; Purdue, M. P.; Troester, M. A.; Hoadley, K. A.; Love, M. I.
10.1101/2020.04.08.032490 — genomics — Posted on 2020-04-09
3381 Functional characterization of germline variants in the TMEM127 tumor suppressor reveals novel insights into its membrane topology and trafficking
Flores, S. K.; Deng, Y.; Cheng, Z.-M.; Zhang, X.; Tao, S.; Saliba, A.; Chu, I.; Wang, E.; Aguiar, R. C. T.; Dahia, P. L. M.
10.1101/2020.04.08.031039 — genetics — Posted on 2020-04-09
3382 Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin
Hayward, J. A.; Tachedjian, M.; Johnson, A.; Gordon, T. B.; Cui, J.; Marsh, G. A.; Baker, M. L.; Wang, L.-F.; Tachedjian, G.
10.1101/2020.04.08.031203 — evolutionary biology — Posted on 2020-04-09
3384 Subepidermal blisters are healed by wedge-shaped keratinocytes of hair follicle origin
Fujimura, Y.; Watanabe, M.; Ohno, K.; Kobayashi, Y.; Takashima, S.; Nakamura, H.; Kosumi, H.; Wang, Y.; Mai, Y.; Lauria, A.; Proserpio, V.; Ujiie, H.; Iwata, H.; Nishie, W.; Nagayama, M.; Oliviero, S.; Donati, G.; Shimizu, H.; Natsuga, K.
10.1101/2020.04.08.032326 — cell biology — Posted on 2020-04-09
3388 Addressable Nanoantennas with Cleared Hotspots for Single-Molecule Detection on a Portable Smartphone Microscope
Trofymchuk, K.; Glembockyte, V.; Grabenhorst, L.; Steiner, F.; Vietz, C.; Close, C.; Pfeiffer, M.; Richter, L.; Schütte, M. L.; Selbach, F.; Yaadav, R.; Zähringer, J.; Wei, Q.; Ozcan, A.; Lalkens, B.; Acuna, G. P.; Tinnefeld, P.
10.1101/2020.04.09.032037 — biophysics — Posted on 2020-04-09
3391 D4: Deep Drug-drug interaction Discovery and Demystification
Noor, A.; Wang, L.; Barnawi, A.; Noor, R.; Assiri, A. A.; Bukhari, S. A. C.; Hoehndorf, R.
10.1101/2020.04.08.032011 — bioinformatics — Posted on 2020-04-09
3395 Phage and bacteria diversification through a prophage acquisition ratchet
Anthenelli, M.; Jasien, E.; Edwards, R. V.; Bailey, B.; Felts, B.; Katira, P.; Nulton, J.; Rohwer, F.; Silveira, C. B.; Luque, A.
10.1101/2020.04.08.028340 — ecology — Posted on 2020-04-09
3396 Driving Integrative Structural Modeling with Serial Capture Affinity Purification
Liu, X.; Zhang, Y.; Wen, Z.; Hao, Y.; Banks, C.; Lange, J. J.; Slaughter, B.; Unruh, J.; Florens, L.; Abmayr, S.; Workman, J.; Washburn, M.
10.1101/2020.04.08.032151 — systems biology — Posted on 2020-04-09
3397 Modulation of adenine phosphoribosyltransferase-mediated salvage to promote diabetic wound healing
Young, G.-H.; Lin, J.-T.; Cheng, Y.-F.; Ho, C.-F.; Kuok, Q.-Y.; Hsu, R.-C.; Liao, W.-R.; Chen, C.-C.; Chen, H.-M.
10.1101/2020.04.08.032128 — pathology — Posted on 2020-04-09
3399 Geographic mosaic of selection by avian predators on hindwing warning colour in a polymorphic aposematic moth
Ronka, K.; Valkonen, J.; Nokelainen, O.; Rojas, B.; Gordon, S.; Burdfield-Steel, E.; Mappes, J.
10.1101/2020.04.08.032078 — ecology — Posted on 2020-04-09
3401 SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis
Bajczyk, M.; Lange, H.; Bielewicz, D.; Szewc, L.; Bhat, S. S.; Dolata, J.; Kuhn, L.; Szweykowska-Kulinska, Z.; Gagliardi, D.; Jarmolowski, A.
10.1101/2020.04.08.032003 — plant biology — Posted on 2020-04-09
3402 Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection
Olson, P. D.; Tracey, A.; Baillie, A.; James, K.; Doyle, S. R.; Buddenborg, S. K.; Rodgers, F. H.; Holroyd, N.; Berriman, M.
10.1101/2020.04.08.031872 — genomics — Posted on 2020-04-09
3405 CytoPy: an autonomous cytometry analysis framework
Burton, R. J.; Ahmed, R.; Cuff, S.; Artemiou, A.; Eberl, M.
10.1101/2020.04.08.031898 — bioinformatics — Posted on 2020-04-09
3408 The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes beneficial microglial functions
Takalo, M.; Wittrahm, R.; Wefers, B.; Parhizkar, S.; Jokivarsi, K.; Kuulasmaa, T.; Mäkinen, P.; Martiskainen, H.; Wurst, W.; Xiang, X.; Marttinen, M.; Poutiainen, P.; Haapasalo, A.; Hiltunen, M.; Haass, C.
10.1101/2020.04.08.031567 — neuroscience — Posted on 2020-04-09
3409 Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus
Temmam, S.; Barbarino, A.; Maso, D.; Behillil, S.; Enouf, V.; Huon, C.; Jaraud, A.; Chevallier, L.; Backovic, M.; Perot, P.; Verwaerde, P.; Tiret, L.; van der Werf, S.; Eloit, M.
10.1101/2020.04.07.029090 — microbiology — Posted on 2020-04-09
3411 Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila
Logeay, R.; Geminard, C.; Lassus, P.; Kantar, D.; Heron-Milhavet, L.; Fischer, B.; Bray, S. J.; Colinge, J.; Djiane, A.
10.1101/2020.02.07.938621 — developmental biology — Posted on 2020-04-09
3412 Big Data Reproducibility: Applications in Brain Imaging and Genomics
Bridgeford, E. W.; Wang, S.; Yang, Z.; Wang, Z.; Xu, T.; Craddock, C.; Dey, J.; Kiar, G.; Gray-Roncal, W.; Coulantoni, C.; Douville, C.; Priebe, C. E.; Caffo, B.; Milham, M.; Zuo, X.-N.; Consortium for Reliability and Reproducibility, ; Vogelstein, J. T.
10.1101/802629 — neuroscience — Posted on 2020-04-09
3414 Structural and functional analysis of a potent sarbecovirus neutralizing antibody
Pinto, D.; Park, Y.-J.; Beltramello, M.; Walls, A. C.; Tortorici, M. A.; Bianchi, S.; Jaconi, S.; Culap, K.; Zatta, F.; De Marco, A.; Peter, A.; Guarino, B.; Spreafico, R.; Cameroni, E.; Case, J. B.; Chen, R. E.; Havenar-Daughton, C.; Snell, G.; Telenti, A.; Virgin, H. W.; Lanzavecchia, A.; Diamond, M. S.; Fink, K.; Veesler, D.; Corti, D.
10.1101/2020.04.07.023903 — immunology — Posted on 2020-04-09
3415 The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2
Berg, T. J.; Marques, C.; Pantazopoulou, V.; Johansson, E.; von Stedingk, K.; Lindgren, D.; Pietras, E. J.; Bergström, T.; Swartling, F. J.; Governa, V.; Bengzon, J.; Belting, M.; Axelson, H.; Squatrito, M.; Pietras, A.
10.1101/2020.02.12.945329 — cancer biology — Posted on 2020-04-09
3416 Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility
Hiltpold, M.; Niu, G.; Kadri, N. K.; Crysnanto, D.; Fang, Z.-H.; Spengeler, M.; Schmitz-Hsu, F.; Fuerst, C.; Schwarzenbacher, H.; Seefried, F. R.; Seehusen, F.; Witschi, U.; Schnieke, A.; Fries, R.; Bollwein, H.; Flisikowski, K.; Pausch, H.
10.1101/2020.01.16.907865 — genomics — Posted on 2020-04-09
3420 Recycling of energy dissipated as heat accounts for high activity of Photosystem II
Zubik, M.; Luchowski, R.; Kluczyk, D.; Grudzinski, W. H.; Maksim, M.; Nosalewicz, A.; Gruszecki, W. I.
10.1101/842591 — plant biology — Posted on 2020-04-09
3421 Epithelial colonies in vitro elongate through collective effects
Comelles, J.; Soumya, S. S.; Anvitha, S.; Salbreux, G.; Jülicher, F.; Inamdar, M. M.; Riveline, D.
10.1101/755181 — biophysics — Posted on 2020-04-09
3423 Risperidone-induced changes in DNA methylation from peripheral blood in first-episode schizophrenia parallel neuroimaging and cognitive phenotype
Hu, M.; Xia, Y.; Zong, X.; Sweeney, J. A.; Bishop, J. R.; Giase, G.; Li, B.; Rubin, L. H.; Chen, X.; Wang, Y.; Li, Z.; He, Y.; Liu, C.; Chen, C.; Chen, X.; Tang, J.
10.1101/2020.03.31.018283 — pharmacology and toxicology — Posted on 2020-04-09
3425 Dynamics of the cell-free DNA methylome of metastatic castration resistant prostate cancer during androgen-targeting treatment
Peter, M. R.; Bilenky, M.; Isserlin, R.; Bader, G. D.; Shen, S. Y.; De Carvalho, D. D.; Hansen, A. R.; Hu, P.; Fleshner, N. E.; Joshua, A. M.; Hirst, M.; Bapat, B.
10.1101/2020.04.08.032565 — cancer biology — Posted on 2020-04-09
3427 Targeted Eicosanoid Profiling Reveals MicroRNA-155 Shifts PGE2/PGD2 Balance Towards Oncogenic State
Kim, S.; Lee, E. S.; Lee, E. J.; Jung, J. Y.; Lee, S. B.; Lee, H. J.; Kim, J.; Kim, H. J.; Lee, J. W.; Son, B. H.; Gong, G.-Y.; Ahn, S.-H.; Chang, S.
10.1101/2020.04.08.032136 — cancer biology — Posted on 2020-04-09
3429 De novo protein synthesis in distinct centrolateral amygdala interneurons is required for associative emotional memories
Shrestha, P.; Shan, Z.; Marmarcz, M.; San Agustin Ruiz, K.; Zerihoun, A. T.; Juan, C.-Y.; Herrero-Vidal, P. M.; Pelletier, J.; Heintz, N.; Klann, E.
10.1101/2020.04.08.028233 — neuroscience — Posted on 2020-04-09
3431 The IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro.
Bukreyeva, N.; Mantlo, E. K.; Sattler, R. A.; Huang, C.; Paessler, S.; Zeldis, J.
10.1101/2020.04.07.028589 — microbiology — Posted on 2020-04-09
3433 Deciphering the scopolamine challenge rat model by preclinical functional MRI
Somogyi, G.; Hlatky, D.; Spisak, T.; Spisak, Z.; Nyitrai, G.; Czurko, A.
10.1101/2020.04.08.031534 — neuroscience — Posted on 2020-04-09
3435 Structural and functional analysis of a potent sarbecovirus neutralizing antibody
Corti, D.; Pinto, D.; Park, Y.-J.; Beltramello, M.; Walls, A. C.; Tortorici, M. A.; Bianchi, S.; Jaconi, S.; Culap, K.; Zatta, F.; De Marco, A.; Peter, A.; Guarino, B.; Spreafico, R.; Cameroni, E.; Case, J. B.; Chen, R. E.; Havenar-Daughton, C.; Snell, G.; Telenti, A.; Virgin, H. W.; Lanzavecchia, A.; Diamond, M. S.; Fink, K.; Veesler, D.
10.1101/2020.04.07.023903 — immunology — Posted on 2020-04-09
3437 Runs of homozygosity in killer whale genomes provide a global record of demographic histories
Hooper, R.; Excoffier, L.; Forney, K.; Gilbert, M. T. P.; Martin, M. D.; Morin, P. A.; Wolf, J. B. W.; Foote, A.
10.1101/2020.04.08.031344 — evolutionary biology — Posted on 2020-04-09
3438 A Single-Objective Light-Sheet Microscope with 200 nm-Scale Resolution.
Sapoznik, E.; Chang, B.-J.; Ju, R. J.; Welf, E. S.; Broadbent, D.; Carisey, A. F.; Stehbens, S. J.; Lee, K.-m.; Marin, A.; Hanker, A. B.; Schmidt, J. C.; Arteaga, C. L.; Yang, B.; Kruithoff, R.; Shepherd, D. P.; Millett-Sikking, A.; York, A. G.; Dean, K. M.; Fiolka, R. P.
10.1101/2020.04.07.030569 — biophysics — Posted on 2020-04-09
3440 Automated Edge-Aware Refinement of Anatomical Atlases in 3D and Its Application to the Developing Mouse Brain
Young, D. M.; Fazel Darbandi, S.; Schwartz, G.; Bonzell, Z.; Yuruk, D.; Nojima, M.; Gole, L.; Rubenstein, J. L.; Yu, W.; Sanders, S. J.
10.1101/2020.04.01.017665 — bioinformatics — Posted on 2020-04-09
3442 More than just front or back: Parietal-striatal-thalamic circuits predict consciousness level
Afrasiabi, M.; Redinbaugh, M. J.; Phillips, J. M.; Kambi, N. A.; Mohanta, S.; Raz, A.; Haun, A. M.; Saalmann, Y. B.
10.1101/2020.04.07.030429 — neuroscience — Posted on 2020-04-09
3445 Deep evolutionary origin of gamete-directed zygote activation by KNOX/BELL transcription factors in green plants
Hisanaga, T.; Fujimoto, S.; Cui, Y.; Sato, K.; Sano, R.; Yamaoka, S.; Kohchi, T.; Berger, F.; Nakajima, K.
10.1101/2020.04.08.031930 — developmental biology — Posted on 2020-04-09
3447 HAPPI GWAS: Holistic Analysis with Pre and Post Integration GWAS
Slaten, M.; Chan, Y. O.; Shrestha, V.; Lipka, A. E.; Angelovici, R.
10.1101/2020.04.07.998690 — bioinformatics — Posted on 2020-04-09
3449 A chemical strategy to control protein networks in vivo
Ziegler, M. J.; Yserentant, K.; Middel, V.; Dunsing, V.; Gralak, A. J.; Pakari, K.; Bargstedt, J.; Kern, C.; Chiantia, S.; Straehle, U.; Herten, D.-P.; Wombacher, R.
10.1101/2020.04.08.031427 — synthetic biology — Posted on 2020-04-09
3454 Recurrent plasticity mechanisms for perceptual decisions in the human brain
Jia, K.; Zamboni, E.; Kemper, V.; Rua, C.; Goncalves, N. R.; Ng, A.; Rodgers, C.; Williams, G.; Goebel, R.; Kourtzi, Z.
10.1101/2020.04.07.030510 — neuroscience — Posted on 2020-04-09
3459 Rapid, field-deployable nucleobase detection and identification using FnCas9
Azhar, M.; Phutela, R.; Ansari, A. H.; Sinha, D.; Sharma, N.; Kumar, M.; Aich, M.; Sharma, S.; Singhal, K.; Lad, H.; Patra, P. K.; Makharia, G.; Chandak, G. R.; Chakraborty, D.; Maiti, S.
10.1101/2020.04.07.028167 — molecular biology — Posted on 2020-04-09
3461 Mosquito cellular immunity at single-cell resolution
Raddi, G.; Ferreira, A. B.; Efremova, M.; Ramirez, J. L.; Cantera, R.; Teichmann, S.; Barillas-Mury, C.; Billker, O.
10.1101/2020.04.08.032508 — immunology — Posted on 2020-04-09
3464 Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High Resolution Imaging Mass Spectrometry
Anderson, D. M.; Messinger, J. D.; Patterson, N. H.; Rivera, E. S.; Kotnala, A.; Spraggins, J. M.; Caprioli, R. M.; Curcio, C. A.; Schey, K. L.
10.1101/2020.04.08.029538 — biochemistry — Posted on 2020-04-09
3465 Physical activity and risk of lung cancer: a two-sample Mendelian randomiza-tion study
Baumeister, S.-E.; Leitzmann, M.; Amos, C.; Hung, R.; Teumer, A.; Baurecht, H.
10.1101/806083 — genetics — Posted on 2020-04-09
3468 Mycobacteria tolerate carbon monoxide by remodelling their respiratory chain
Bayly, K.; Cordero, P. R. F.; Huang, C.; Schittenhelm, R. B.; Grinter, R.; Greening, C.
10.1101/2020.04.08.032912 — microbiology — Posted on 2020-04-09
3470 Unravelling the effect of a potentiating anti-Factor H antibody on atypical hemolytic uremic syndrome associated factor H variants
Dekkers, G.; Brouwer, M.; Jeremiasse, J.; Kamp, A.; Biggs, R. M.; van Mierlo, G.; Lauder, S.; Katti, S.; Kuijpers, T. W.; Rispens, T.; Jongerius, I.
10.1101/2020.04.08.026906 — immunology — Posted on 2020-04-09
3471 Inhibition of 15-PGDH Protects Mice from Immune-mediated Bone Marrow Failure
Smith, J. N. P.; Otegbeye, F.; Jogasuria, A.; Christo, K. F.; Gerson, S. L.; Markowitz, S. D.; Desai, A. B.
10.1101/2020.04.07.030312 — immunology — Posted on 2020-04-09
3472 CNSA: a data repository for archiving omics data
Guo, X.; Chen, F.; Gao, F.; Li, L.; Liu, K.; You, L.; Hua, C.; Yang, F.; Liu, W.; Peng, C.; Wang, L.; Yang, X.; Zhou, F.; Tong, J.; Cai, J.; Li, Z.; Wan, B.; Zhang, L.; Yang, T.; Zhang, M.; Yang, L.; Yang, Y.; Zeng, W.; Wang, B.; Wei, X.; Xu, X.
10.1101/2020.04.07.030833 — genomics — Posted on 2020-04-09
3474 Development of a simple and accurate molecular tool for Spodoptera frugiperda species identification using LAMP
Kim, J.; Nam, H. Y.; Kwon, M.; Kim, H. J.; Yi, H.-J.; Haenniger, S.; Unbehend, M.; Heckel, D.
10.1101/2020.04.07.029678 — ecology — Posted on 2020-04-09
3476 Clonal thermal preferences affect the strength of the temperature-size rule
Stuczynska, A.; Sobczyk, M.; Fialkowska, E.; Kocerba-Soroka, W.; Pajdak-Stos, A.; Starzycka, J.; Walczynska, A.
10.1101/2020.04.08.031286 — ecology — Posted on 2020-04-09
3480 Cystoliths in Ficus leaves: increasing carbon fixation in saturating light by light scattering off a mineral substrate
Pierantoni, M.; Paudel, I.; Raphael, B.; Tenne, R.; Brumfeld, V.; Slomka, S.; Oron, D.; Addadi, L.; Weiner, S.; Klein, T.
10.1101/2020.04.08.030999 — plant biology — Posted on 2020-04-09
3482 SYNAPTIC RTP801 CONTRIBUTES TO MOTOR LEARNING DYSFUNCTION IN HUNTINGTON DISEASE
Martin-Flores, N.; Perez-Sisques, L.; Creus-Muncunill, J.; Masana, M.; Gines, S.; Alberch, J.; Perez-Navarro, E.; Malagelada, C.
10.1101/2020.04.07.030080 — neuroscience — Posted on 2020-04-09
3484 Neural responses to happy, fearful and angry faces of varying identities in 5- and 7-month-old infants
Bayet, L.; Perdue, K. L.; Behrendt, H. F.; Richards, J. E.; Westerlund, A.; Cataldo, J. K.; Nelson, C. A.
10.1101/2020.04.07.030395 — neuroscience — Posted on 2020-04-09
3485 Bitbow: a digital format of Brainbow enables highly efficient neuronal lineage tracing and morphology reconstruction in single brains
Li, Y.; Walker, L. A.; Zhao, Y.; Edwards, E. M.; Michki, N. S.; Cheng, H. P. J.; Ghazzi, M.; Chen, T. Y.; Chen, M.; Roossien, D. H.; Cai, D.
10.1101/2020.04.07.030593 — neuroscience — Posted on 2020-04-09
3486 Proof of concept of a novel ex vivo, in situ method for MRI and histological brain assessment
Maranzano, J.; Dadar, M.; Bertrand-Grenier, A.; Frigon, E.-M.; Pellerin, J.; Plante, S.; Duchesne, S.; Tardif, C. L.; Boire, D.; Bronchti, G.
10.1101/2020.04.08.031682 — neuroscience — Posted on 2020-04-09
3489 Hybrid origin of Populus tomentosa Carr. identified through genome sequencing and phylogenomic analysis
An, X.; Gao, K.; Chen, Z.; Li, J.; Yang, X.; Zhou, J.; Guo, T.; Zhao, T.; Huang, S.; Miao, D.; Khan, W. U.; Rao, P.; Ye, M.; Lei, B.; Liao, W.; Wang, J.; Ji, L.; Li, Y.; Guo, B.; Mustafa, N. S.; Li, S.; Yun, Q.; Keller, S. R.; Mao, J.; Zhang, R.; Strauss, S. H.
10.1101/2020.04.07.030692 — genomics — Posted on 2020-04-09
3490 Endemic island songbirds as windows into evolution in small effective population sizes
Leroy, T.; Rousselle, M.; Tilak, M.-K.; Caizergues, A.; Scornavacca, C.; Recuerda Carrasco, M.; Fuchs, J.; Illera, J. C.; De Swardt, D. H.; Thebaud, C.; Mila, B.; Nabholz, B.
10.1101/2020.04.07.030155 — evolutionary biology — Posted on 2020-04-09
3491 Microbial community composition is affected by press, but not pulse, seawater intrusion
Mobilian, C.; Wisnoski, N. I.; Lennon, J. T.; Alber, M.; Widney, S.; Craft, C. B.
10.1101/2020.04.07.030791 — ecology — Posted on 2020-04-09
3492 A Connectome and Analysis of the Adult Drosophila Central Brain
Scheffer, L. K.; Xu, C. S.; Januszewski, M.; Lu, Z.; Takemura, S.-y.; Hayworth, K. J.; Huang, G.; Shinomiya, K.; Maitlin-Shepard, J.; Berg, S.; Clements, J.; Hubbard, P. M.; Katz, W. T.; Umayam, L.; Zhao, T.; Ackerman, D.; Blakely, T.; Bogovic, J.; Dolafi, T.; Kainmueller, D.; Kawase, T.; Khairy, K.; Leavitt, L.; Li, P. H.; Lindsey, L.; Neubarth, N.; Olbris, D. J.; Otsuna, H.; Trautman, E. T.; Ito, M.; Goldammer, J.; Wolff, T.; Svirskas, R.; Schlegel, P.; Neace, E.; Knecht, C.; Alvarado, C. X.; Bailey, D. A.; Ballinger, S.; Borycz, J. A.; Canino, B. S.; Cheatham, N.; Cook, M.; Dreher, M.; Ducl
10.1101/2020.04.07.030213 — bioinformatics — Posted on 2020-04-09
3493 IDseq - An Open Source Cloud-based Pipeline and Analysis Service for Metagenomic Pathogen Detection and Monitoring
Kalantar, K. L.; Carvalho, T.; de Bourcy, C. F. A.; Dimitrov, B.; Dingle, G.; Egger, R.; Han, J.; Holmes, O. B.; Juan, Y.; King, R.; Kislyuk, A.; Mariano, M.; Reyenoso, L. V.; Rissato Cruz, D.; Sheu, J.; Tang, J.; Wang, J.; Zhang, M. A.; Zhong, E.; Ahyong, V.; Lay, S.; Chea, S.; Bohl, J. A.; Manning, J. E.; Tato, C. M.; DeRisi, J. L.
10.1101/2020.04.07.030551 — bioinformatics — Posted on 2020-04-09
3496 The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype
Damaghi, M.; West, J.; Robertson-Tessi, M.; Xu, L.; Ferrall-Fairbanks, M. C.; Stewart, P. A.; Persi, E. A.; Fridley, B. L.; Altrock, P. M.; Gatenby, R.; Sims, p. A.; Anderson, A. R.; Gillies, R. J.
10.1101/2020.04.07.029975 — cancer biology — Posted on 2020-04-09
3498 Parallel social information processing circuits are differentially impacted in autism
Lewis, E. M.; Stein-O'Brien, G.; Patino, A.; Nardou, R.; Grossman, C. D.; Brown, M.; Bangamwabo, B.; Ndiaye, N.; Giovinazzo, D.; Dardani, I.; Jiang, C.; Goff, L.; Dolen, G.
10.1101/2020.03.13.990549 — neuroscience — Posted on 2020-04-09
3500 A novel factor essential for unconventional secretion of chitinase Cts1
Reindl, M.; Stock, J.; Hussnaetter, K. P.; Genc, A.; Brachmann, A.; Schipper, K.
10.1101/2020.02.07.938613 — microbiology — Posted on 2020-04-09
3501 Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome
Lilley, T.; Wilson, I.; Field, K. A.; Reeder, D. M.; Vodzak, M. E.; Turner, G. G.; Kurta, A.; Blomberg, A. S.; Hoff, S.; Herzog, C.; Sewall, B. J.; Paterson, S.
10.1101/764647 — evolutionary biology — Posted on 2020-04-08
3504 Ecology of domestic dogs Canis familiaris as an emerging reservoir of Guinea worm Dracunculus medinensis infection
McDonald, R. A.; Wilson-Aggarwal, J. K.; Swan, G. J. F.; Goodwin, C. E. D.; Moundai, T.; Sankara, D.; Biswas, G.; Zingeser, J. A.
10.1101/2020.02.19.939827 — ecology — Posted on 2020-04-09
3505 Integrin Affinity Modulation Critically Regulates Atherogenic Endothelial Activation in vitro and in vivo
Al Yafeai, Z.; Peretik, J. M.; Pearson, B. H.; Bhattarai, U.; Wang, D.; Petrich, B. G.; Orr, A. W.
10.1101/2020.02.14.949941 — cell biology — Posted on 2020-04-09
3506 Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
Tulpule, A.; Guan, J.; Neel, D. S.; Lin, Y. P.; Heslin, A.; Allegakoan, H. R.; Perati, S.; Ramirez, A. D.; Shi, X.; Yang, B.; Feng, S.; Makhija, S.; Brown, D.; Huang, B.; Bivona, T. G.
10.1101/704312 — cancer biology — Posted on 2020-04-09
3507 Human-derived NLS enhance the gene transfer efficiency of chitosan
Bitoque, D. B.; Morais, J.; Oliveira, A. V.; Sequeira, R. L.; Calado, S. M.; Fortunato, T. M.; Simao, S.; Rosa da Costa, A. M.; Silva, G. A.
10.1101/2020.03.13.990390 — bioengineering — Posted on 2020-04-09
3508 Structure of human ferroportin bound to hepcidin reveals mechanisms of iron homeostasis
Billesboelle, C.; Azumaya, C.; Kretsch, R. C.; Powers, A. S.; Gonen, S.; Schneider, S.; Arvedson, T.; Dror, R.; Cheng, Y.; Manglik, A.
10.1101/2020.03.16.993006 — biochemistry — Posted on 2020-04-09
3512 Parameter-dependent shift from rational to irrational decisions in mice
Schneider, N. A.; Ballintyn, B. N.; Katz, D. B.; Lisman, J.; Pi, H.-J.
10.1101/701722 — neuroscience — Posted on 2020-04-08
3514 The mutational constraint spectrum quantified from variation in 141,456 humans
Karczewski, K. J.; Francioli, L. C.; Tiao, G.; Cummings, B. B.; Alföldi, J.; Wang, Q.; Collins, R. L.; Laricchia, K. M.; Ganna, A.; Birnbaum, D. P.; Gauthier, L. D.; Brand, H.; Solomonson, M.; Watts, N. A.; Rhodes, D.; Singer-Berk, M.; England, E. M.; Seaby, E. G.; Kosmicki, J. A.; Walters, R. K.; Tashman, K.; Farjoun, Y.; Banks, E.; Poterba, T.; Wang, A.; Seed, C.; Whiffin, N.; Chong, J. X.; Samocha, K. E.; Pierce-Hoffman, E.; Zappala, Z.; O'Donnell-Luria, A. H.; Vallabh Minikel, E.; Weisburd, B.; Lek, M.; Ware, J. S.; Vittal, C.; Armean, I. M.; Bergelson, L.; Cibulskis, K.; Connolly, K. M.;
10.1101/531210 — genomics — Posted on 2020-04-08
3515 Estimating the effect-size of gene dosage on cognitive ability across the coding genome
Huguet, G.; Schramm, C.; Douard, E. A.; Tamer, P.; Main, A.; Monin, P.; England, J.; Jizi, K.; Renne, T.; Poirier, M.; Nowak, S.; Martin, C.-O.; Younis, N.; Knoth, I. S.; Jean Louis, M.; Saci, Z.; Auger, M.; Tihy, F.; Mathonnet, G.; Maftei, C.; Leveille, F.; Porteous, D.; Davies, G.; Redmond, P.; Harris, S. E.; Lemyre, E.; Schumann, G.; Bourgeron, T.; Pausova, Z.; Paus, T.; Karama, S.; Lippe, S.; Deary, I.; Almasy, L.; Labbe, A.; Glahn, D.; Greenwood, C. M.; Jacquemont, S.
10.1101/2020.04.03.024554 — genetics — Posted on 2020-04-08
3516 Horizontal transmission and recombination maintain forever young bacterial symbiont genomes
Russell, S. L.; Pepper-Tunick, E.; Svedberg, J.; Byrne, A.; Ruelas Castillo, J.; Vollmers, C.; Beinart, R.; Corbett-Detig, R.
10.1101/754028 — evolutionary biology — Posted on 2020-04-08
3522 Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
Ronda, O. A. H. O.; van de Heijning, B. J. M.; de Bruin, A.; Thomas, R. E.; Martini, I.; Koehorst, M.; Gerding, A.; Koster, M. H.; Bloks, V. W.; Jurdzinski, A.; Mulder, N. L.; Havinga, R.; van der Beek, E. M.; Reijngoud, D.-J.; Kuipers, F.; Verkade, H. J.
10.1101/2020.04.08.031617 — pathology — Posted on 2020-04-08
3523 Neural harmonics reflect grammaticality
Tavano, A.; Blohm, S.; Knoop, C.; Muralikrishnan, R.; Scharinger, M.; Wagner, V.; Thiele, D.; Ghitza, O.; Ding, N.; Menninghaus, W.; Poeppel, D.
10.1101/2020.04.08.031575 — neuroscience — Posted on 2020-04-08
3525 Molecular investigations on a chimeric strain of Staphylococcus aureus sequence type 80
Gawlik, D.; Ruppelt-Lorz, A.; Müller, E.; Reissig, A.; Hotzel, H.; Braun, S. D.; Söderquist, B.; Ziegler-Cordts, A.; Ehricht, R.; Monecke, S.
10.1101/2020.04.08.031591 — microbiology — Posted on 2020-04-08
3533 Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet
Kellard, J. A.; Rorsman, N. J. G.; Hill, T. G.; Armour, S. L.; van der Bunt, M.; Rorsman, P.; Knudsen, J. G.; Briant, L.
10.1101/2020.04.07.028258 — cell biology — Posted on 2020-04-08
3536 Visual function restoration in genetically blind mice via endogenous cellular reprogramming
Fu, X.; Zhu, J.; Duan, Y.; Li, G.; Cai, H.; Zheng, L.; Zhang, C.; Jin, Z.; Fu, X.-D.; Zhang, K.
10.1101/2020.04.08.030981 — cell biology — Posted on 2020-04-08
3543 Separable influences of reward value on visual processing and choice
Soltani, A.; Rakhshan, M.; Schafer, R. J.; Burrows, B.; Moore, T.
10.1101/2020.04.07.029942 — neuroscience — Posted on 2020-04-08
3544 Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression
Di Domenico, A.; Pipinikas, C. P.; Maire, R. S.; Bräutigam, K.; Simillion, C.; Dettmer, M. S.; Vassella, E.; Thirlwell, C.; Perren, A.; Marinoni, I.
10.1101/2020.04.08.029785 — cancer biology — Posted on 2020-04-08
3545 Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations
Morris, B.; Curtin, L.; Hawkins-Daarud, A.; Hubbard, M. E.; Rahman, R.; Smith, S. J.; Auer, D.; Tran, N. L.; Hu, L. S.; Eschbacher, J. M.; Smith, K. A.; Stokes, A.; Swanson, K. R.; Owen, M. R.
10.1101/2020.04.08.024091 — cancer biology — Posted on 2020-04-08
3552 The missing role of gray matter in studying brain controllability
Jamalabadi, H.; Zuberer, A.; Kumar, V. J.; Li, M.; Alizadeh, S.; Moradi, A. A.; Gaser, C.; Esterman, M.; Walter, M.
10.1101/2020.04.07.030015 — neuroscience — Posted on 2020-04-08
3554 Neuronal adaptation during the prolonged cognitive task improves visual stimulus processing
Maksimenko, V. A.; Frolov, N. S.; Kuc, A.; Hramov, A. E.; Pisarchik, A. N.; Lebedev, M.
10.1101/2020.04.07.029959 — neuroscience — Posted on 2020-04-08
3555 DIFFUSION MRI OF THE UNFOLDED HIPPOCAMPUS
Hussain, U.; DeKraker, J.; Rajakumar, N.; Baron, C. A.; Khan, A. R.
10.1101/2020.04.07.029850 — neuroscience — Posted on 2020-04-08
3556 LAMP-Seq: Population-Scale COVID-19 Diagnostics Using a Compressed Barcode Space
Schmid-Burgk, J. L.; Li, D.; Feldman, D.; Slabicki, M.; Borrajo, J.; Strecker, J.; Cleary, B.; Regev, A.; Zhang, F.
10.1101/2020.04.06.025635 — molecular biology — Posted on 2020-04-08
3559 Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival
Denner, J.; Laengin, M.; Reichart, B.; Krueger, L.; Fiebig, U.; Mokelke, M.; Radan, J.; Mayr, T.; Milusev, A.; Luther, F.; Sorvillo, N.; Rieben, R.; Brenner, P.; Walz, C.; Wolf, E.; Roshani, B.; Stahl-Hennig, C.; Abicht, J.-M.
10.1101/2020.04.07.029702 — microbiology — Posted on 2020-04-08
3561 Comparison of the in vitro activity of novel and established nitrification inhibitorsapplied in agriculture: challenging the effectiveness of the currently availablecompounds
Papadopoulou, E. S.; Bachtsevani, E.; Lampronikou, E.; Adamou, E.; Katsaouni, A.; Thion, C.; Vasileiadis, S.; Menkissoglu- Spiroudi, U.; Nicol, G. W.; Karpouzas, D. G.
10.1101/2020.04.07.023168 — microbiology — Posted on 2020-04-08
3562 Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.
Lavaert, M.; Liang, K. L.; Vandamme, N.; Park, J.-E.; Roels, J.; Kowalczyk, M. S.; Li, B.; Ashenberg, O.; Tabaka, M.; Dionne, D.; Tickle, T. L.; Slyper, M.; Rozenblatt-Rosen, O.; Vandekerckhove, B.; Leclercq, G.; Regev, A.; Van Vlierberghe, P.; Guilliams, M.; Teichmann, S. A.; Saeys, Y.; Taghon, T.
10.1101/2020.04.07.007237 — immunology — Posted on 2020-04-08
3565 The relationship between microbial population size and disease in the Arabidopsis thaliana phyllosphere
Karasov, T. L.; Neumann, M.; Duque-Jaramillo, A.; Kersten, S.; Bezrukov, I.; Schroeppel, B.; Symeonidi, E.; Lundberg, D. S.; Regalado, J.; Shirsekar, G.; Bergelson, J.; Weigel, D.
10.1101/828814 — plant biology — Posted on 2020-04-08
3566 How community adaptation affects biodiversity-ecosystem functioning relationships
Aubree, F.; David, P.; Jarne, P.; Loreau, M.; Mouquet, N.; Calcagno, V.
10.1101/867820 — evolutionary biology — Posted on 2020-04-08
3567 UMI-VarCal: a new UMI-based variant caller that efficiently improves low-frequency variant detection in paired-end sequencing NGS libraries
Sater, V.; Viailly, P.-J.; Lecroq, T.; Prieur-Gaston, E.; Bohers, E.; Viennot, M.; Ruminy, P.; Dauchel, H.; Vera, P.; Jardin, F.
10.1101/775817 — bioinformatics — Posted on 2020-04-08
3570 Women diagnosed with gestational diabetes according to the newest WHO criteria have a raised genetic risk for type 2 diabetes
Hughes, A. E.; Hayes, M. G.; Egan, A. M.; Patel, K. A.; Scholtens, D. M.; Lowe, L. P.; Lowe, W. L.; Dunne, F. P.; Hattersley, A. T.; Freathy, R. M.
10.1101/671057 — genetics — Posted on 2020-04-08
3571 Epigenetic transgenerational effects on RNAi in Arabidopsis
Hu, Q.; Ailhas, J.; Blevins, T.; Klahre, U.; Vazquez, F.; Mette, M. F.; Meins, F.
10.1101/2020.04.05.026641 — plant biology — Posted on 2020-04-08
3573 Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity
Cruvinel, E.; Ogusuku, I.; Cerioni, R.; Goncalves, J.; Goes, M. E.; Silva, A. C.; Alvim, J.; Pereira, A.; Dariolli, R.; Valadares, M.; Biagi, D. G.
10.1101/663047 — cell biology — Posted on 2020-04-08
3574 Anti-apoptotic clone 11 derived peptides induce in vitro death of CD4+ T cells susceptible to HIV-1 infection
Mikhailova, A.; Valle-Casuso, J. C.; David, A.; Monceaux, V.; Volant, S.; Pereira-Bittencourt Passaes, C.; Elfidha, A.; Muller-Trutwin, M.; Poyet, J. L.; Saez-Cirion, A.
10.1101/2020.04.06.028860 — microbiology — Posted on 2020-04-08
3575 Chromatin dynamics during hematopoiesis reveal discrete regulatory modules instructing differentiation
Georgolopoulos, G.; Iwata, M.; Psatha, N.; Nishida, A.; Som, T.; Yiangou, M.; Stamatoyannopoulos, J. A.; Vierstra, J.
10.1101/2020.04.02.022566 — developmental biology — Posted on 2020-04-08
3576 The structure of bacterial toxin CNFY reveals requirements for secretion, host cell recognition and endosomal release
Chaoprasid, P.; Lukat, P.; Mühlen, S.; Schweer, J. N. G.; Heidler, T. V.; Gazdag, E. M.; Stradal, T.; Dersch, P.; Blankenfeldt, W.
10.1101/2020.04.07.029181 — biochemistry — Posted on 2020-04-08
3577 A Single-Objective Light-Sheet Microscope with 200 nm-Scale Resolution.
Sapoznik, E.; Chang, B.-J.; Ju, R. J.; Welf, E. S.; Broadbent, D.; Carisey, A. F.; Stehbens, S. J.; Lee, K.-m.; Marin, A.; Hanker, A. B.; Schmidt, J. C.; Arteaga, C. L.; Yang, B.; Kruithoff, R.; Millett-Sikking, A.; York, A. G.; Dean, K. M.; Fiolka, R. P.
10.1101/2020.04.07.030569 — biophysics — Posted on 2020-04-08
3578 A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling
Filipcik, P.; Latham, S. L.; Cadell, A. L.; Day, C. L.; Croucher, D. R.; Mace, P. D.
10.1101/2020.04.07.030676 — biochemistry — Posted on 2020-04-08
3579 A collection of genetic mouse lines and related tools for inducible and reversible intersectional misexpression
Ahmadzadeh, E.; Bayin, N. S.; Qu, X.; Singh, A.; Madisen, L.; Stephen, D.; Zeng, H.; Joyner, A. L.; Rosello-Diez, A.
10.1101/754192 — molecular biology — Posted on 2020-04-08
3582 Abrogation of RAB27A expression transiently affects melanoma cell proliferation
Guo, D.; Beaumont, K. A.; Sharp, D. M.; Lui, G. Y. L.; Weninger, W.; Haass, N. K.; Tikoo, S.
10.1101/2019.12.27.889329 — cancer biology — Posted on 2020-04-08
3587 Estimates of cortical column orientation improveMEG source inversion
Bonaiuto, J. J.; Afdideh, F.; Ferez, M.; Wagstyl, K.; Mattout, J.; Bonnefond, M.; Barnes, G. R.; Bestmann, S.
10.1101/810267 — neuroscience — Posted on 2020-04-08
3596 Lipidated poly(amino acid) nanostructures as versatile therapeutic delivery vehicles
Smith, J. D.; Cardwell, L. N.; Porciani, D.; Greenwald, A. J.; Ellis, A. C.; Schulte, M. C.; Wang, X.; Schoenherr, E. T.; Seim, G. F.; Anderson, J. E.; Nguyen, J. A.; Tata, R. R.; Lange, M. J.; Burke, D. H.; Daniels, M. A.; Ulery, B. D.
10.1101/2020.04.07.004333 — bioengineering — Posted on 2020-04-08
3602 Inflammation promotes adipocyte lipolysis via IRE1 kinase
Foley, K. P.; Chen, Y.; Barra, N. G.; Heal, M.; Kwok, K.; Tamrakar, A. K.; Chi, W.; Duggan, B. M.; Henriksbo, B. D.; Liu, Y.; Schertzer, J. D.
10.1101/2020.04.07.030148 — physiology — Posted on 2020-04-08
3603 Genetic reduction of PERK-eIF2α signaling in dopaminergic neurons drives cognitive and age-dependent motor dysfunction
Longo, F.; Mancini, M.; Ibraheem, P. L.; Aryal, S.; Mesini, C.; Patel, J. C.; Penhous, E.; Rahman, N.; Donohue, M.; Santini, E.; Rice, M. E.; Klann, E.
10.1101/2020.04.07.028241 — neuroscience — Posted on 2020-04-08
3606 The Harsh Microenvironment in Early Breast Cancer Select for a Warburg Phenotype
Damaghi, M.; West, J.; Robertson-Tessi, M.; Xu, L.; Ferrall-Fairbanks, M. C.; Stewart, P. A.; Persi, E. A.; Fridley, B. L.; Altrock, P. M.; Gatenby, R.; Sims, p. A.; Anderson, A. R.; Gillies, R. J.
10.1101/2020.04.07.029975 — cancer biology — Posted on 2020-04-08
3607 Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques
Natunen, T.; Martiskainen, H.; Marttinen, M.; Gabbouj, S.; Koivisto, H.; Kemppainen, S.; Kaipainen, S.; Takalo, M.; Svobodova, H.; Leppänen, L.; Kemiläinen, B.; Ryhänen, S.; Kuulasmaa, T.; Rahunen, E.; Juutinen, S.; Mäkinen, P.; Miettinen, P.; Rauramaa, T.; Pihlajamäki, J.; Haapasalo, A.; Leinonen, V.; Tanila, H.; Hiltunen, M.
10.1101/2020.04.07.027292 — neuroscience — Posted on 2020-04-08
3610 The mRNA-binding protein HuR is a kinetically-privileged electrophile sensor
Poganik, J. R.; Van Hall-Beauvais, A.; Long, M. J. C.; Disare, M. T.; Zhao, Y.; Aye, Y.
10.1101/2020.04.07.029330 — biochemistry — Posted on 2020-04-08
3611 Diminished adherence of snail hemocytes to schistosome sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factor of Biomphalaria glabrata
Coelho, F. S.; Rodpai, R.; Miller, A.; Karinshak, S. E.; Mann, V. H.; dos Santos Carvalho, O.; Caldeira, R. L.; de Moraes Mourao, M.; Brindley, P. J.; Tanno, W. I.
10.1101/2020.04.07.029629 — molecular biology — Posted on 2020-04-08
3612 Population connectivity predicts vulnerability to white-nose syndrome in the Chilean myotis (Myotis chiloensis) - a genomics approach
Lilley, T.; Sävilammi, T. M.; Ossa, G.; Blomberg, A. S.; Vasemägi, A.; Yung, V.; Vendrami, D. L.; Johnson, J. S.
10.1101/2020.04.07.029256 — evolutionary biology — Posted on 2020-04-08
3613 Ancestral absence of electron transport chains in Patescibacteria and DPANN
Beam, J. P.; Becraft, E. D.; Brown, J. M.; Schulz, F. P.; Jarett, J. K.; Bezuidt, O.; Poulton, N. J.; Clark, K.; Dunfield, P. F.; Ravin, N. V.; Spear, J. R.; Hedlund, B. P.; Kormas, K. A.; Sievert, S. M.; Elshahed, M. S.; Barton, H. A.; Stott, M. B.; Eisen, J. A.; Moser, D. P.; Onstott, T. C.; Woyke, T.; Stepanauskas, R.
10.1101/2020.04.07.029462 — evolutionary biology — Posted on 2020-04-08
3614 Lamin B2 follows lamin A/C- mediated nuclear mechanics and cancer cell invasion efficacy
Vortmeyer-Krause, M.; te Lindert, M.; te Riet, J.; te Boekhorst, V. t.; Marke, R.; Perera, R.; Isermann, P.; van Oorschot, T.; Zwerger, M.; Yang, F.; Svoren, M.; Matzvamuse, A.; Lammerding, J.; Friedl, P.; Wolf, K.
10.1101/2020.04.07.028969 — cell biology — Posted on 2020-04-08
3615 Disseminating cells in human tumours acquire an EMT stem cell state that is predictive of metastasis
Youssef, G.; Gammon, L.; Ambler, L.; Wicker, B.; Patel, S.; Cottom, H.; Piper, K.; Mackenzie, I. C.; Philpott, M. P.; Biddle, A.
10.1101/2020.04.07.029009 — cancer biology — Posted on 2020-04-08
3618 Peer review and preprint policies are unclear at most major journals
Klebel, T.; Reichmann, S.; Polka, J.; McDowell, G.; Penfold, N.; Hindle, S.; Ross-Hellauer, T.
10.1101/2020.01.24.918995 — scientific communication and education — Posted on 2020-04-08
3620 Functional Role of Second Heart Field-derived Cells in Thoracic Aortopathies
Sawada, H.; Higashi, H.; Rateri, D. L.; Chen, J. Z.; Moorleghen, J. J.; Howatt, D. A.; Lu, H. S.; Morgan, S.; Lee, L. H.; Singh, S. A.; Aikawa, M.; Majesky, M. W.; Daugherty, A.
10.1101/2020.02.02.930917 — pathology — Posted on 2020-04-07
3621 The Dementias Platform UK (DPUK) Data Portal
Bauermeister, S.; Orton, C.; Thompson, S.; Barker, R.; Bauermeister, J.; Ben-Shlomo, Y.; Brayne, C.; Burn, D.; Campbell, A.; Calvin, C.; Chandran, S.; Chaturvedi, N.; Chene, G.; Chessell, I.; Corbett, A.; Davis, D.; Denis, M.; DuFouil, C.; Elliott, P.; Fox, N.; Hill, D.; Hofer, S.; Hu, M.; Jindra, C.; Kee, F.; Kim, C.-H.; Kim, C.; Kivimaki, M.; Koychev, I.; Lawson, R.; Linden, G.; Lyons, R.; MacKay, C.; Matthews, P.; McGuiness, B.; Middleton, L.; Moody, C.; Moore, K.; Na, D. L.; O'Brien, J.; Ourselin, S.; Paranjothy, S.; Park, K. S.; Porteous, D.; Richards, M.; Ritchie, C.; Rohrer, J.; Rossor,
10.1101/582155 — neuroscience — Posted on 2020-04-07
3622 Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up
Kim, S.; Greene, D. J.; Badke D'Andrea, C.; Bihun, E. C.; Koller, J. M.; O'Reilly, B.; Schlaggar, B. L.; Black, K. J.
10.1101/2020.02.05.935908 — neuroscience — Posted on 2020-04-07
3623 When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma
Tribble, J. R.; Kokkali, E.; Otmani, A.; Plastino, F.; Lardner, E.; Vohra, R.; Kolko, M.; Andre, H.; Morgan, J. E.; Williams, P. A.
10.1101/853275 — neuroscience — Posted on 2020-04-07
3626 The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues
Haight, J. L.; Campus, P.; Maria-Rios, C. E.; Johnson, A. M.; Klumpner, M. S.; Kuhn, B. N.; Covelo, I. R.; Morrow, J. D.; Flagel, S.
10.1101/2020.03.01.972174 — neuroscience — Posted on 2020-04-08
3629 Similar gut bacterial microbiota in two fruit-feeding moth pests collected from different host species and locations
Gong, Q.; Cao, L.-J.; Chen, J.-C.; Gong, Y.-J.; Pu, D.-Q.; Huang, Q.; Hoffmann, A. A.; Wei, S.-J.
10.1101/2020.04.06.028886 — microbiology — Posted on 2020-04-07
3631 Freshwater monitoring by nanopore sequencing
Urban, L.; Holzer, A.; Baronas, J. J.; Hall, M.; Braeuninger-Weimer, P.; Scherm, M. J.; Kunz, D. J.; Perera, S. N.; Martin-Herranz, D. E.; Tipper, E. T.; Salter, S. J.; Stammnitz, M. R.
10.1101/2020.02.06.936302 — microbiology — Posted on 2020-04-07
3632 Protein QTL analysis of IGF-I and its binding proteins provides insights into growth biology
Bartell, E. R.; Fujimoto, M.; Khoury, J. C.; Khoury, P. R.; Vedantam, S.; Hirschhorn, J.; Dauber, A.
10.1101/2020.03.25.007724 — genetics — Posted on 2020-04-08
3633 Adaptive mitochondrial regulation of the proteasome
Meul, T.; Berschneider, K.; Schmitt, S.; Mayr, C. H.; Mattner, L. F.; Schiller, H. B.; Yazgili, A.; Wang, X.; Lukas, C.; Prehn, C.; Adamski, J.; Graf, E.; Schwarzmayr, T.; Perocchi, F.; Kukat, A.; Trifunovic, A.; Kremer, L.; Prokisch, H.; Popper, B.; von Toerne, C.; Hauck, S. M.; Zischka, H.; Meiners, S.
10.1101/2020.04.07.026161 — cell biology — Posted on 2020-04-08
3634 Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells
Wang, Z.; Li, X.; Yang, J.; Gong, Y.; Zhang, H.; Qiu, X.; Liu, Y.; Zhou, C.; Chen, Y.; Greenbaum, J.; Cheng, L.; Hu, Y.; Xie, J.; Yang, X.; Li, Y.; Schiller, M. R.; Tan, L.-J.; Tang, S.-Y.; Shen, H.; Xiao, H.-M.; deng, H.-W.
10.1101/2020.04.06.027904 — cell biology — Posted on 2020-04-08
3639 SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signatures
Tlemsani, C.; Pongor, L.; Girard, L.; Roper, N.; Elloumi, F.; Varma, S.; Luna, A.; Rajapakse, V. N.; Sebastian, R.; Kohn, K. W.; Krushkal, J.; Aladjem, M.; Teicher, B.; Meltzer, P. S.; Reinhold, W. C.; Minna, J. D.; Thomas, A.; Pommier, Y.
10.1101/2020.03.09.980623 — cancer biology — Posted on 2020-04-07
3640 Proposed pathway for kinesin backstepping
Toleikis, A.; Carter, N. J.; Cross, R. A.
10.1101/838433 — biophysics — Posted on 2020-04-07
3642 Physical basis of lumen shape and stability in a simple epithelium
Vasquez, C. G.; Vachharajani, V. T.; Garzon-Coral, C.; Dunn, A. R.
10.1101/746792 — cell biology — Posted on 2020-04-07
3643 Multi-fluorescence high-resolution episcopic microscopy (MF-HREM) for three dimensional imaging of adult murine organs
Walsh, C.; Holroyd, N.; Finnerty, E.; Ryan, S. G.; Sweeney, P. W.; Shipley, R. J.; Walker-Samuel, S.
10.1101/2020.04.03.023978 — biophysics — Posted on 2020-04-07
3644 Genetic Distance Calculation Based on Locality Sensitive Hashing
Pathirana, T.; Bandara, S.; Gamage, G.; Silva, G.; Wickramaarachchi, A.; Perera, I.
10.1101/2020.04.06.027250 — bioinformatics — Posted on 2020-04-07
3646 Dynamic relocalization of the cytosolic type III secretion system components prevents premature protein secretion at low external pH
Wimmi, S.; Balinovic, A.; Jeckel, H.; Selinger, L.; Lampaki, D.; Eisemann, E.; Meuskens, I.; Linke, D.; Drescher, K.; Endesfelder, U.; Diepold, A.
10.1101/869214 — microbiology — Posted on 2020-04-07
3650 Bradycardic mice undergo effective heart rate improvement after specific homing to the sino-atrial node and differentiation of adult muscle derived stem cells.
Mesirca, P.; Mamaeva, D.; Bidaud, I.; Baudot, M.; Davaze, R.; DiFrancesco, M. L.; Mitutsova, V.; Torrente, A. G.; Arsic, N.; Nargeot, J.; Striessnig, J.; Lee, A.; Lamb, N.; Mangoni, M.; Fernandez, A.
10.1101/393512 — cell biology — Posted on 2020-04-07
3651 Adipose-tissue derived signals control bone remodelling.
Fu, H.; Madel, M.-B.; Pierroz, D.; Schiffrin, M.; Winkler, C.; Wilson, A.; Pochon, C.; Toffoli, B.; Jouzeau, J.-Y.; Gilardi, F.; Ferrari, S.; Bonnet, N.; BLIN-WAKKACH, C.; Desvergne, B.; MOULIN, D.
10.1101/2020.03.02.972711 — cell biology — Posted on 2020-04-07
3657 MicroRNA arm switching regulated by uridylation
Kim, H.; Kim, J.; Yu, S.; Lee, Y.-Y.; Park, J.; Choi, R. J.; Yoon, S.-J.; Kang, S.-G.; Kim, V. N.
10.1101/2020.04.06.027813 — molecular biology — Posted on 2020-04-07
3659 Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction
Gnan, S.; Flyamer, I. M.; Klein, K. N.; Castelli, E.; Rapp, A.; Maiser, A.; Chen, N.; Weber, P.; Enervald, E.; Cardoso, C. M.; Bickmore, W. A.; Gilbert, D. M.; Buonomo, S.
10.1101/812156 — genomics — Posted on 2020-04-07
3664 Diversified regulation of circadian clock gene expression following whole genome duplication
West, A. C.; Iversen, M.; Jorgensen, E. H.; Sandve, S. R.; Hazlerigg, D. G.; Wood, S. H.
10.1101/2020.03.22.002162 — physiology — Posted on 2020-04-07
3666 Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs
Do, C.; Dumont, E. L. P.; Salas, M.; Castano, A.; Mujahed, H.; Maldonado, L.; Singh, A.; Bhagat, G.; Lehman, S.; Christiano, A. M.; Madhavan, S.; Nagy, P. L.; Green, P. H. R.; Feinman, R.; Trimble, C.; Marder, K.; Honig, L.; Monk, C.; Goy, A.; Chow, K.; Goldlust, S.; Kaptain, G.; Siegel, D.; Tycko, B.
10.1101/815605 — genomics — Posted on 2020-04-07
3668 Impact of Tiny Targets on Glossina fuscipes quanzensis, the primary vector of Human African Trypanosomiasis in the Democratic Republic of Congo.
Tirados, I.; Hope, A.; Selby, R.; Mpembele, F.; Miaka, E. M.; Boelaert, M.; Lehane, M. J.; Torr, S. J.; Stanton, M. C.
10.1101/2020.04.07.029587 — ecology — Posted on 2020-04-07
3671 An in vitro ovarian explant culture system to examine sex change in a hermaphroditic fish
Goikoetxea, A.; Damsteegt, E. L.; Todd, E. V.; McNaughton, A.; Gemmell, N. J.; Lokman, P. M.
10.1101/2020.04.06.026880 — zoology — Posted on 2020-04-07
3677 High admixture between forest and cultivated chestnut (Castanea sativa Mill.) in France
Bouffartigue, C.; Debille, S.; Fabreguettes, O.; Ramos Cabrer, A.; Pereira-Lorenzo, S.; Flutre, T.; Harvengt, L.
10.1101/792259 — genetics — Posted on 2020-04-07
3679 A signaling axis involving CNOT3, Aurora B and ERK promotes mesendodermal differentiation of ES cells in response to FGF2 and BMP4
Sarkar, M.; Martufi, M.; Roman-Trufero, M.; Wang, Y.-F.; Whilding, C.; Dormann, D.; Sabbattini, P.; Dillon, N.
10.1101/756932 — developmental biology — Posted on 2020-04-07
3680 Applying machine learning in motor activity time series of depressed bipolar and unipolar patients.
Jakobsen, P.; Garcia-Ceja, E.; Riegler, M.; Stabel, L. A.; Nordgreen, T.; Torresen, J.; Fasmer, O. B.; Oedegaard, K. J.
10.1101/2020.04.07.029561 — bioinformatics — Posted on 2020-04-07
3683 Assessing metacommunity processes through signatures in spatiotemporal turnover of community composition
Jabot, F.; Laroche, F.; Massol, F.; Arthaud, F.; Crabot, J.; Dubart, M.; Blanchet, S.; Munoz, F.; David, P.; Datry, T.
10.1101/480335 — ecology — Posted on 2020-04-07
3688 The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program
Mondal, B.; Jin, H.; Kallappagoudar, S.; Sedkov, Y.; Martinez, T.; Sentmanat, M. F.; Poet, G. J.; Li, C.; Fan, Y.; Pruett-Miller, S. M.; Herz, H.-M.
10.1101/2020.04.07.029751 — molecular biology — Posted on 2020-04-07
3692 Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice.
Gheware, A. P.; Panda, L.; Khanna, K.; Jain, V.; Bhatraju, N. K.; Sagar, S.; Kumar, M.; Singh, V. P.; Mukerji, M.; Agrawal, A.; Prasher, B.
10.1101/2020.04.01.019430 — immunology — Posted on 2020-04-07
3695 Subthreshold repertoire and threshold dynamics of midbrain dopamine neuron firing in vivo.
Otomo, K.; Perkins, J.; Kulkarni, A.; Stojanovic, S.; Roeper, J.; Paladini, C. A.
10.1101/2020.04.06.028829 — neuroscience — Posted on 2020-04-07
3698 ObLiGaRe doxycycline Inducible (ODIn) Cas9 system driving pre-clinical drug discovery, from design to cancer treatment
Lundin, A.; Porritt, M. J.; Jaiswal, H.; Seeliger, F.; Johansson, C.; Wahad Bidar, A.; Badertscher, L.; Davies, E. J.; Hardaker, E.; Martins, C. P.; Admyre, T.; Taheri-Ghahfarokhi, A.; Bradley, J.; Schantz, A.; Alaeimahabadi, B.; Clausen, M.; Xiufeng, X.; Mayr, L.; Nitsch, R.; Bohlooly-Y, M.; Barry, S. T.; Maresca, M.
10.1101/2020.04.06.028803 — genomics — Posted on 2020-04-07
3702 Insulin/IGF signaling and TOR promote vitellogenesis via inducing juvenile hormone biosynthesis
Zhu, S.; Liu, F.; Zeng, H.; Li, N.; Ren, C.; Su, Y.; Zhou, S.; Wang, G.; Palli, S. R.; Wang, J.; Qin, Y.; Li, S.
10.1101/2020.04.06.028639 — developmental biology — Posted on 2020-04-07
3707 Impact of Advanced Maternal Age on Physiologic Adaptations to Pregnancy in Vervet Monkeys
Plant, M.; Armstrong, C.; Ruggiero, A.; Sherrill, C.; Uberseder, B.; Jeffries, R.; Nevarez, J.; Jorgensen, M. J.; Kavanagh, K.; Quinn, M. A.
10.1101/2020.04.06.027771 — physiology — Posted on 2020-04-07
3709 Scalar human brain responses to vectorial economic choice options: a concept-driven approach
Chi U Seak, L.; Volkmann, K.; Pastor-Bernier, A.; Stasiak, A.; Grabenhorst, F.; Schultz, W.
10.1101/2020.04.06.028001 — neuroscience — Posted on 2020-04-07
3711 Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses
Wybo, W. A. M.; Jordan, J.; Ellenberger, B.; Mengual, U. M.; Nevian, T.; Senn, W.
10.1101/2020.04.06.028183 — neuroscience — Posted on 2020-04-07
3713 Similar gut bacterial microbiota in two fruit-feeding moth pests collected from different host species and locations
Gong, Q.; Cao, L.-J.; Chen, J.-C.; Gong, Y.-J.; Pu, D.-Q.; Huang, Q.; Hoffmann, A. A.; Wei, S.-J.
10.1101/2020.04.06.028886 — microbiology — Posted on 2020-04-07
3714 Signatures of mito-nuclear climate adaptation in a warbler species complex
Wang, S.; Ore, M.; Mikkelsen, E. K.; Lee-Yaw, J.; Rohwer, S.; Irwin, D. E.
10.1101/2020.04.06.028506 — evolutionary biology — Posted on 2020-04-07
3716 Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1
Travis, S. M.; DAmico, K.; Yu, I.-M.; Hamid, S.; Ramirez-Arellano, G.; Jeffrey, P. D.; Hughson, F. M.
10.1101/2020.04.07.029496 — cell biology — Posted on 2020-04-07
3718 Generating functional protein variants with variational autoencoders
Hawkins-Hooker, A.; Depardieu, F.; Baur, S.; Couairon, G.; Chen, A.; Bikard, D.
10.1101/2020.04.07.029264 — bioinformatics — Posted on 2020-04-07
3722 Transmembrane Stem Cell Factor Protein Therapeutics EnhanceRevascularization in Ischemia without Mast Cell Activation
Takematsu, E.; Auster, J.; Chen, P.-C.; Srinath, S.; Canga, S.; Singh, A.; Majid, M.; Sherman, M.; Dunn, A.; Graham, A.; Martin, P.; Baker, A.
10.1101/2020.04.06.028563 — bioengineering — Posted on 2020-04-07
3724 Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire
Lin, X.; George, J. T.; Schafer, N. P.; Clementi, C.; Onuchic, J. N.; Levine, H.
10.1101/2020.04.06.028415 — biophysics — Posted on 2020-04-07
3730 POMK Regulates Dystroglycan Function via LARGE-mediated Elongation of Matriglycan
Walimbe, A. S.; Yang, T.; Yonekawa, T.; Venzke, D.; Anderson, M. E.; Torelli, S.; Manzur, A.; Yu, L.; Devereaux, M.; Cuellar, M.; Prouty, S.; O'Campo Landa, S.; Muntoni, F.; Campbell, K. P.
10.1101/2020.04.06.007948 — biochemistry — Posted on 2020-04-07
3731 Congenital Zika Syndrome is associated with maternal genetic background
Azamor, T.; Cunha, D. P.; da Silva, A. M. V.; Bezerra, O. C. d. L.; Ribeiro-Alves, M.; Calvo, T. L.; Kehdy, F. d. S. G.; Manta, F. S. d. N.; Pinto, T. G.; Ferreira, L. P.; Portari, E. A.; Guida, L. d. C.; Gomes, L.; Moreira, M. E. L.; de Carvalho, E. F.; Cardoso, C. C.; Muller, M.; Neves, P. C. d. C.; Vasconcelos, Z.; Moraes, M. O.
10.1101/715862 — genetics — Posted on 2020-04-07
3733 Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers
Gudikote, J. P.; Cascone, T.; Poteete, A.; Sitthideatphaiboon, P.; Wu, Q.; Morikawa, N.; Zhang, F.; Peng, S.; Tong, P.; Li, L.; Shen, L.; Nilsson, M.; Jones, P.; Sulman, E. P.; Wang, J.; Bourdon, J.-C.; Johnson, F. M.; Heymach, J.
10.1101/2020.04.06.026955 — cancer biology — Posted on 2020-04-07
3734 Neural basis of common-pool resources exploitation
Martinez-Saito, M.; Andraszewicz, S.; Klucharev, V.; Rieskamp, J.
10.1101/2020.04.05.026419 — neuroscience — Posted on 2020-04-07
3735 Invasion and maintenance of spore killing in ascomycete fungi
martinossi, i.; Veller, C.; Ament-Velasquez, S. L.; Vogan, A.; Rueffler, C.; Johannesson, H.
10.1101/2020.04.06.026989 — evolutionary biology — Posted on 2020-04-07
3736 Store Independent Ca2+ Entry Regulates the DNA Damage Response in Breast Cancer Cells
Makena, M. R.; Ko, M.; Mekile, A. X.; Dang, D. K.; Warrington, J. M.; Buckhaults, P. J.; Talbot, C.; Rao, R.
10.1101/2020.04.06.027946 — cancer biology — Posted on 2020-04-07
3738 Characterization of essential eggshell proteins from Aedes aegypti mosquitoes
Simington, C. J.; Oscherwitz, M. E.; Peterson, A. J.; Rascon, A. A.; Massani, B. B.; Miesfeld, R.; ISOE, J.
10.1101/2020.04.06.027706 — developmental biology — Posted on 2020-04-07
3739 The spatial distributions of pre-mRNAs suggest post-transcriptional splicing of specific introns within endogenous genes
Cote, A. J.; Cote, C. J.; Bayatpour, S.; Drexler, H. L.; Alexander, K. A.; Chen, F.; Wassie, A. T.; Boyden, E. S.; Berger, S.; Churchman, L. S.; Raj, A.
10.1101/2020.04.06.028092 — cell biology — Posted on 2020-04-07
3740 Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster
Vigano, M. A.; Ell, C.-M.; Kustermann, M. M.; Aguilar, G.; Matsuda, S.; Zhao, N.; Stasevich, T. J.; Pyrowolakis, G.; Affolter, M.
10.1101/2020.04.06.027599 — cell biology — Posted on 2020-04-07
3742 Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2
Bertolin, G.; Alves-Guerra, M.-C.; Burel, A.; Prigent, C.; Le Borgne, R.; Tramier, M.
10.1101/2020.04.06.027896 — cell biology — Posted on 2020-04-07
3743 Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells
Wang, Z.; Li, X.; Yang, J.; Gong, Y.; Zhang, H.; Qiu, X.; Liu, Y.; Zhou, C.; Chen, Y.; Greenbaum, J.; Cheng, L.; Hu, Y.; Xie, J.; Yang, X.; Li, Y.; Schiller, M. R.; Tan, L.-J.; Tang, S.-Y.; Shen, H.; Xiao, H.; deng, H.-W.
10.1101/2020.04.06.027904 — cell biology — Posted on 2020-04-07
3744 Multimodal Nonlinear Optical and Thermal Imaging Platform for Label-Free Characterization of Biological Tissue
Adams, W. R.; Mehl, B.; Leiser, E.; Wang, M.; Patton, S.; Throckmorton, G. A.; Jenkins, J. L.; Ford, J. B.; Gautam, R.; Brooker, J.; Jansen, E. D.; Mahadevan-Jansen, A.
10.1101/2020.04.06.023820 — biophysics — Posted on 2020-04-07
3745 The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes
Landsberger, N.; Bedogni, F.; Scaramuzza, L.; Clementina, C. G.; Genni, D.; Mirabella, F.; Pozzi, D.; Chiacchiaretta, M.; De Simone, M.; Conforti, P.; Pagani, M.; Benfenati, F.; Cesca, F.; De Rocco, G.
10.1101/2020.04.06.027995 — neuroscience — Posted on 2020-04-07
3746 MicroRNA arm switching regulated by uridylation
Kim, H.; Kim, J.; Yu, S.; Lee, Y.-Y.; Park, J.; Choi, R. J.; Yoon, S.-J.; Kang, S.-G.; Kim, V. N.
10.1101/2020.04.06.027813 — molecular biology — Posted on 2020-04-07
3748 ATM inhibition drives metabolic adaptation via induction of macropinocytosis
Chen, C.-W.; Buj, R.; Dahl, E. S.; Leon, K. E.; Varner, E. L.; von Krusenstiern, E.; Snyder, N. W.; Aird, K. M.
10.1101/2020.04.06.027565 — cancer biology — Posted on 2020-04-07
3751 Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair
Nakamura, M.; Dominguez, A. N. M.; Verboon, J. M.; Abreu-Blanco, M. T.; Liu, R.; Delrow, J. J.; Parkhurst, S. M.
10.1101/2020.04.06.028662 — developmental biology — Posted on 2020-04-07
3752 Concerted action of kinesin-1 KIF5B and kinesin-3 KIF13B promotes efficient transport of exocytotic vesicles to microtubule plus ends
Serra-Marques, A.; Martin, M.; Katrukha, E. A.; Grigoriev, I.; Peeters, C. A. E.; Liu, Q.; Hooikaas, P. J.; Yao, Y.; Smal, I.; Pedersen, L. B.; Meijering, E. A.; Kapitein, L. C.; Akhmanova, A.
10.1101/2020.04.06.027862 — cell biology — Posted on 2020-04-07
3753 Deep learning models for lipid-nanoparticle-based drug delivery
Harrison, P. J.; Wieslander, H.; Sabirsh, A.; Karlsson, J.; Malmsjö, V.; Hellander, A.; Wählby, C.; Spjuth, O.
10.1101/2020.04.06.027672 — cell biology — Posted on 2020-04-07
3756 Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity
Jones, B.; Evans, R. L.; Mylrea, N.; Chaudhury, D.; Luo, C.; Pierce, C.; Guan, B.; Gordon, W.; Wilmot, C.; Kazlauskas, R.
10.1101/2020.04.06.027797 — biochemistry — Posted on 2020-04-07
3760 Phenotypic switching and adaptive strategies of cancer cells in response to stress: insights from live cell imaging and mathematical modeling
Nam, A.; Mohanty, A.; Bhattacharya, S.; Kotnala, S.; Achuthan, S.; Hari, K.; Nathan, A.; Rangarajan, G.; Massarelli, E.; Levine, H.; Jolly, M. K.; Kulkarni, P.; Salgia, R.
10.1101/2020.04.06.028472 — cancer biology — Posted on 2020-04-07
3762 Precise, high-throughput production of multicellular spheroids with a bespoke 3D bioprinter
Utama, R. H.; Atapattu, L.; O'Mahony, A. P.; Fife, C. M.; Baek, J.; Allard, T.; O'Mahony, K. J.; Ribeiro, J.; Gaus, K.; Kavallaris, M.; Gooding, J.
10.1101/2020.04.06.028548 — bioengineering — Posted on 2020-04-07
3764 CryoEM Structure of CtBP2 Confirms Tetrameric Architecture
Jecrois, A. M.; Dcona, M. M.; Deng, X.; Bandyopadhyay, D.; Grossman, S. R.; Schiffer, C. A.; Royer, W. E.
10.1101/2020.04.06.027573 — biochemistry — Posted on 2020-04-07
3766 Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances
Matsuda, Y.; Ozawa, N.; Shinozaki, T.; Wakabayashi, K.-i.; Suzuki, K.; Kawano, Y.; Ohtsu, I.; Tatebayashi, Y.
10.1101/2020.03.26.009423 — neuroscience — Posted on 2020-04-07
3767 Analysis of stress responses in Astyanax larvae reveals heterogeneity among different populations
Chin, J. S. R.; Loomis, C.; Albert, L. T.; Medina-Trenche, S.; Kowalko, J. E.; Keene, A. C.; Duboue, E. R.
10.1101/2020.04.06.027649 — neuroscience — Posted on 2020-04-07
3768 Insights into calcium signaling and gene expression in astrocytes uncovered with 129S4 Slc1a3-2A-CreERT2 knock-in mice
Kaczmarczyk, L.; Reichenbach, N.; Blank, N.; Jonson, M.; Dittrich, L.; Petzold, G.; Jackson, W. S.
10.1101/2020.04.06.027714 — neuroscience — Posted on 2020-04-07
3773 A protocol for adding knowledge to Wikidata, a case report
Waagmeester, A.; Willighagen, E. L.; Su, A. I.; Kutmon, M.; Gayo, J. E. L.; Fernandez-Alvarez, D.; Schaap, P. J.; Verhagen, L. M.; Koehorst, J. J.
10.1101/2020.04.05.026336 — bioinformatics — Posted on 2020-04-07
3775 Whole genome sequencing analysis of the cardiometabolic proteome
Gilly, A. L.; Park, Y.-C.; Png, G.; Barysenka, A.; Fischer, I.; Bjornland, T.; Southam, L.; Suveges, D.; Neumeyer, S.; Rayner, N. W.; Tsafantakis, E.; Karaleftheri, M.; Dedoussis, G.; Zeggini, E.
10.1101/854752 — genetics — Posted on 2020-04-07
3777 Ectodomain shedding of L-selectin by ADAM17 in canine neutrophils
Snyder, K. M.; McAloney, C.; Montel, J. S.; Modiano, J. F.; Walcheck, B.
10.1101/2020.04.06.027433 — immunology — Posted on 2020-04-07
3780 Primate phageomes are structured by superhost phylogeny and environment
Gogarten, J. F.; Rühlemann, M.; Archie, E.; Tung, J.; Akoua-Koffi, C.; Bang, C.; Deschner, T.; Muyembe-Tamfum, J.-J.; Robbins, M. M.; Schubert, G.; Surbeck, M.; Wittig, R. M.; Zuberbühler, K.; Baines, J. F.; Franke, A.; Leendertz, F. H.; Calvignac-Spencer, S.
10.1101/2020.04.06.011684 — microbiology — Posted on 2020-04-06
3785 Tracking the outbreak. An optimized delimiting survey strategy for Xylella fastidiosa.
Lazaro, E.; Sese, M.; Lopez-Quilez, A.; Conesa, D.; Dalmau, V.; Ferrer-Matoses, A.; Vicent, A.
10.1101/2020.03.05.978668 — pathology — Posted on 2020-04-06
3787 Dense cellular segmentation for EM using 2D-3D neural network ensembles
Guay, M. D.; Emam, Z. A. S.; Anderson, A. B.; Aronova, M. A.; Leapman, R. D.
10.1101/2020.01.05.895003 — cell biology — Posted on 2020-04-06
3791 Detecting fine and elaborate movements with piezo sensors, from heartbeat to the temporal organization of behavior
Carreno-Munoz, M. I.; Medrano, M. C.; Leinekugel, T.; Bompart, M.; Martins, F.; Subashi, E.; Miguelez, C.; Aby, F.; Frick, A.; Landry, M.; Grana, M.; Leinekugel, X.
10.1101/2020.04.03.024711 — animal behavior and cognition — Posted on 2020-04-06
3792 Grapevine rootstocks affect growth-related phenotypes
Migicovsky, Z.; Cousins, P.; Jordan, L. M.; Myles, S.; Striegler, R. K.; Verdegaal, P.; Chitwood, D. H.
10.1101/864850 — plant biology — Posted on 2020-04-06
3795 Reward impacts visual statistical learning
Park, S. H.; Rogers, L. L.; Johnson, M. R.; Vickery, T. J.
10.1101/2020.04.04.025668 — neuroscience — Posted on 2020-04-06
3797 In vivo imaging of the kinetics of microglial self-renewal and maturation in the adult visual cortex
Mendes, M. S.; Atlas, J.; Brehm, Z.; Ladron de Guevara Ruiz, A.; McCall, M.; Majewska, A.
10.1101/2020.03.05.977553 — neuroscience — Posted on 2020-04-06
3799 dSNE: a visualization approach for use with decentralized data
Saha, D. K.; Calhoun, V. D.; DU, Y.; FU, Z.; Panta, S. R.; Plis, S. M.
10.1101/826974 — neuroscience — Posted on 2020-04-06
3800 Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease
Xu, J.; Bankov, G.; Kim, M.; Wretlind, A.; Lord, J.; Green, R.; Hodges, A.; Hye, A.; Aarsland, D.; Velayudhan, L.; Dobson, R.; Proitsi, P.; Legido-Quigley, C.; AddNeuroMed Consortium,
10.1101/2020.03.18.995464 — neuroscience — Posted on 2020-04-06
3804 DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP
Bruce, E. A.; Huang, M.-L.; Perchetti, G. A.; Tighe, S.; Hoffman, J. J.; Laaguiby, P.; Gerrard, D. L.; Nalla, A.; Wei, Y.; Greninger, A. L.; Diehl, S. A.; Shirley, D. J.; Leonard, D. G. B.; Huston, C. D.; Kirkpatrick, B. D.; Dragon, J.; Crothers, J. W.; Jerome, K. R.; Botten, J. W.
10.1101/2020.03.20.001008 — microbiology — Posted on 2020-04-06
3806 Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production
Fintelman-Rodrigues, N.; Sacramento, C. Q.; Ribeiro Lima, C.; Souza da Silva, F.; Ferreira, A.; Mattos, M.; de Freitas, C. S.; Cardoso Soares, V.; da Silva Gomes Dias, S.; Temerozo, J. R.; Miranda, M.; Matos, A. R.; Bozza, F. A.; Carels, N.; Roberto Alves, C.; Siqueira, M. M.; Bozza, P. T.; Souza, T. M. L.
10.1101/2020.04.04.020925 — microbiology — Posted on 2020-04-06
3808 Random access DNA memory in a scalable, archival file storage system
Banal, J. L.; Shepherd, T. R.; Berleant, J. D.; Huang, H.; Reyes, M.; Ackerman, C. M.; Blainey, P.; Bathe, M.
10.1101/2020.02.05.936369 — bioengineering — Posted on 2020-04-06
3809 An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors' CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design
Herst, C. V.; Burkholz, S.; Sidney, J.; Sette, A.; Harris, P. E.; Massey, S.; Brasel, T.; Cunha-Neto, E.; Rosa, D. S.; Chao, W. C. H.; Carback, R. T.; Hodge, T.; Wang, L.; Ciotlos, S.; Lloyd, P.; Rubsamen, R. M.
10.1101/2020.02.25.963546 — immunology — Posted on 2020-04-06
3811 Knowledge Beacons: Web Service Workflow for FAIR Data Harvesting of Distributed Biomedical Knowledge
Hannestad, L. M.; Dancik, V.; Suen, W. T. I.; Godden, M.; Huellas-Bruskiewicz, K. C.; Good, B. M.; Mungall, C. J.; Bruskiewich, R. M.
10.1101/2020.04.06.027425 — bioinformatics — Posted on 2020-04-06
3813 Idiosyncratic liver alterations of five frog species to land use changes in the Brazilian Cerrado
Franco-Belussi, L.; Provete, D. B.; Borges, R. E.; de Oliveira, C.; Santos, L. R. d. S.
10.1101/837534 — zoology — Posted on 2020-04-06
3814 Non-food crop Rosa caninaL leaf and twig extracts as a source of nutrients and bioactive compounds
Kubczak, M.; Khassenova, A. B.; Skalski, B.; Michlewska, S.; Wielanek, M.; Aralbayeva, A. N.; Murzakhmetova, M. K.; Zamaraeva, M.; Skłodowska, M.; Bryszewska, M.; Ionov, M.
10.1101/2020.04.06.027383 — plant biology — Posted on 2020-04-06
3815 Situation of antibiotic resistance in Bangladesh and its association with resistance genes for horizontal transfer
Safain, K. S.; Bhuyan, G. S.; Tasnim, S.; Hasib, S. H.; Sultana, R.; Islam, M. S.; Mahmud-Un-Nabi, M. A.; Sarker, S. K.; Noor, F. A.; Rahat, A.; Bhuiyan, M. A. M.; Islam, M. T.; Manzoor, F.; Anwar, S.; Leung, D.; Qadri, S. S.; Qadri, F.; Mannoor, K.
10.1101/2020.04.06.027391 — microbiology — Posted on 2020-04-06
3816 COVID-19 Vaccine Candidates: Prediction and Validation of 174 SARS-CoV-2 Epitopes
Prachar, M.; Justesen, S.; Steen-Jensen, D. B.; Thorgrimsen, S. P.; Jurgons, E.; Winther, O.; Bagger, F. O.
10.1101/2020.03.20.000794 — immunology — Posted on 2020-04-06
3817 Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth
Sakabe, N.; Aneas, I.; Knoblauch, N.; Sobreira, D. R.; Clark, N.; Paz, C.; Horth, C.; Ziffra, R.; Kaur, H.; Liu, X.; Anderson, R.; Morrison, J.; Cheung, V. C.; Grotegut, C.; Reddy, T. E.; Jacobsson, B.; Hallman, M.; Teramo, K.; Murtha, A.; Kessler, J.; Grobman, W.; Zhang, G.; Muglia, L. J.; Rana, S.; Lynch, V. J.; Crawford, G. E.; Ober, C.; He, X.; Nobrega, M. A.
10.1101/2020.04.06.017079 — genomics — Posted on 2020-04-06
3824 Selective role of Nck1 in atherogenic inflammation and plaque formation
Alfaidi, M.; Acosta, C. H.; Wang, D.; Traylor, J. G.; Orr, A. W.
10.1101/668129 — pathology — Posted on 2020-04-06
3826 Secondary metabolism in the gill microbiota of shipworms (Teredinidae) as revealed by comparison of metagenomes and nearly complete symbiont genomes
Altamia, M. A.; Lin, Z.; Trindade-Silva, A. E.; Uy, I. D.; Shipway, J. R.; Veras Wilke, D.; Concepcion, G. P.; Distel, D. L.; Schmidt, E. W.; Haygood, M. G.
10.1101/826933 — microbiology — Posted on 2020-04-06
3828 PARTITIONING AMONG NICHE AND NEUTRAL EXPLANATIONS FOR METACOMMUNITY PATTERNS IN CERRADO STREAM FISH COMMUNITIES
Vieira, T. B.; Da Silva, L. C. N.; Casatti, L.; Romero, R.; Garro, F. L. T.; de Aquino, P. D. P. U.; dos Santos Pompeu, P.; De Marco, P.
10.1101/2020.04.06.027417 — ecology — Posted on 2020-04-06
3832 Optical Aberration Correction via Phase Diversity and Deep Learning
Krishnan, A. P.; Belthangady, C.; Nyby, C.; Lange, M.; Yang, B.; Royer, L. A.
10.1101/2020.04.05.026567 — developmental biology — Posted on 2020-04-06
3834 Using single-plant -omics in the field to link maize genes to functions and phenotypes
Cruz, D. F.; De Meyer, S.; Ampe, J.; Sprenger, H.; Herman, D.; Van Hautegem, T.; De Block, J.; Inze, D.; Nelissen, H.; Maere, S.
10.1101/2020.04.06.027300 — systems biology — Posted on 2020-04-06
3836 A rare variant in Anp32B impairs influenza virus replication in human cells
Staller, E.; Baillon, L.; Frise, R.; Peacock, T. P.; Sheppard, C. M.; Sancho-Shimizu, V.; Barclay, W. S.
10.1101/2020.04.06.027482 — microbiology — Posted on 2020-04-06
3838 Adaptive actin organization counteracts elevated membrane tension to ensure robust endocytosis
Kaplan, C.; Kenny, S. J.; Chen, S.; Schoeneberg, J.; Sitarska, E.; Diz-Munoz, A.; Xu, K.; Drubin, D. G.
10.1101/2020.04.05.026559 — cell biology — Posted on 2020-04-06
3840 Tissue-specific multiOMICs analysis of atrial fibrillation
Assum, I.; Krause, J.; Scheinhardt, M. O.; Hammer, E.; Mueller, C.; Boerschel, C. S.; Voelker, U.; Conradi, L.; Geelhoed, B.; Zeller, T.; Schnabel, R.; Heinig, M.
10.1101/2020.04.06.021527 — genetics — Posted on 2020-04-06
3841 Single cell plasticity and population coding stability in auditory thalamus upon associative learning
Taylor, J. A.; Hasegawa, M.; Benoit, C. M.; Freire, J. A.; Theodore, M.; Ganea, D. A.; Lu, T.; Gründemann, J.
10.1101/2020.04.06.026401 — neuroscience — Posted on 2020-04-06
3842 Pseudomonas aeruginosa is capable of natural transformation in biofilms
Nolan, L. M.; Turnbull, L.; Katrib, M.; Osvath, S. R.; Losa, D.; Lazenby, J. J.; Whitchurch, C. B.
10.1101/859553 — microbiology — Posted on 2020-04-06
3843 Sex determination through X-Y heterogamety in Salix nigra
Sanderson, B. J.; Feng, G.; Hu, N.; Carlson, C. H.; Smart, L. B.; Keefover-Ring, K.; Yin, T.; Ma, T.; Liu, J.; DiFazio, S.; Olson, M. S.
10.1101/2020.03.23.000919 — genomics — Posted on 2020-04-06
3844 Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth
Sakabe, N.; Aneas, I.; Knoblauch, N.; Sobreira, D. R.; Clark, N.; Paz, C.; Horth, C.; Ziffra, R.; Kaur, H.; Liu, X.; Anderson, R.; Morrison, J.; Cheung, V. C.; Grotegut, C.; Reddy, T. E.; Jacobsson, B.; Hallman, M.; Teramo, K.; Murtha, A.; Kessler, J.; Grobman, W.; Zhang, G.; Muglia, L. J.; Rana, S.; Lynch, V. J.; Crawford, G. E.; Ober, C.; He, X.; Nobrega, M. A.
10.1101/2020.04.06.017079 — genomics — Posted on 2020-04-06
3845 Causal relationships between substance use and insomnia
Pasman, J. A.; Smit, D. J. A.; Kingma, L.; Vink, J. M.; Treur, J. L.; Verweij, K. J. H.
10.1101/2020.04.06.027003 — genetics — Posted on 2020-04-06
3849 Causally Linking Neural Dominance to Perceptual Dominance in a Multisensory Conflict
Yun, K.; Bhattacharya, J.; Sandkuhler, S.; Lin, Y.-J.; Iwaki, S.; Shimojo, S.
10.1101/2020.04.06.027227 — neuroscience — Posted on 2020-04-06
3851 The evolution of red colour vision is linked to coordinated rhodopsin tuning in lycaenid butterflies
Lienard, M. A.; Bernard, G. D.; Allen, A. A.; Lassance, J.-M.; Song, S.; Rabideau Childers, R. A.; Yu, N.; Ye, D.; Stephenson, A.; Valencia Montoya, W. A.; Salzman, S.; Whitaker, M. R.; Calonje, M.; Pierce, N. E.
10.1101/2020.04.06.027102 — evolutionary biology — Posted on 2020-04-06
3853 An in vitro ovarian explant culture system to examine sex change in a hermaphroditic fish
Goikoetxea, A.; Damsteegt, E. L.; Todd, E. V.; McNaughton, A.; Gemmell, N. J.; Lokman, P. M.
10.1101/2020.04.06.026880 — zoology — Posted on 2020-04-06
3854 Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome
Okhovat, M.; Nevonen, K. A.; Davis, B.; Michener, P.; Ward, S.; Milhaven, M.; Harshman, L.; Sohota, A.; Fernandes, J. D.; Salama, S. R.; O'Neill, R. J.; Ahituv, N.; Veeramah, K. R.; Carbone, L.
10.1101/765230 — evolutionary biology — Posted on 2020-04-06
3856 Accurate Identification of SARS-CoV-2 from Viral Genome Sequences using Deep Learning
Lopez-Rincon, A.; Tonda, A.; Mendoza-Maldonado, L.; Claassen, E.; Garssen, J.; Kraneveld, A. D.
10.1101/2020.03.13.990242 — bioinformatics — Posted on 2020-04-06
3859 Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion
Wanuske, M.-T.; Brantschen, D.; Schinner, C.; Stüdle, C.; Walter, E.; Hiermaier, M.; Vielmuth, F.; Waschke, J.; Spindler, V.
10.1101/2020.04.06.027185 — cell biology — Posted on 2020-04-06
3860 In-Silico evidence for two receptors based strategy of SARS-CoV-2
Milanetti, E.; Miotto, M.; Di Rienzo, L.; Monti, M.; Gosti, G.; Ruocco, G.
10.1101/2020.03.24.006197 — biophysics — Posted on 2020-04-06
3862 Redistribution of cholesterol from vesicle to plasmalemma controls fusion pore geometry
Rituper, B.; Gucek, A.; Lisjak, M.; Gorska, U.; Sakanovic, A.; Trkov Bobnar, S.; Lasic, E.; Bozic, M.; Abbineni, P. S.; Jorgacevski, J.; Kreft, M.; Verkhratsky, A.; Platt, F. M.; Anderluh, G.; Stenovec, M.; Bozic, B.; Coorssen, J. R.; Zorec, R.
10.1101/2020.04.06.027169 — cell biology — Posted on 2020-04-06
3863 Inhibition of cell membrane ingression at the division site by cell wall in fission yeast
Chew, T. G.; Lim, T. C.; Oaski, Y.; Huang, J.; Kamnev, A.; Osumi, M.; Balasubramanian, M.
10.1101/2020.04.06.027193 — cell biology — Posted on 2020-04-06
3866 Genomic evaluation of circulating proteins for drug target characterisation and precision medicine
Folkersen, L.; Gustafsson, S.; Wang, Q.; Hvidberg Hansen, D.; Hedman, A. K.; Schork, A.; Page, K.; Zhernakova, D. V.; Wu, Y.; Peters, J.; Ericsson, N.; Bergen, S. E.; Boutin, T.; Bretherick, A. D.; Enroth, S.; Kalnapenkis, A.; Gadin, J. R.; Suur, B.; Chen, Y.; Matic, L.; Gale, J. D.; Lee, J.; Zhang, W.; Quazi, A.; Ala-Korpela, M.; Choi, S. H.; Claringbould, A.; Danesh, J.; Davey-Smith, G.; de Masi, F.; Elmstahl, S.; Engstrom, G.; Fauman, E.; Fernandez, C.; Franke, L.; Franks, P.; Giedraitis, V.; Haley, C.; Hamsten, A.; Ingason, A.; Johansson, A.; Joshi, P. K.; Lind, L.; Lindgren, C. M.; Lubitz
10.1101/2020.04.03.023804 — genetics — Posted on 2020-04-06
3868 Biological characterization of Euscelidius variegatus iflavirus 1
Ottati, S.; Persico, A.; Rossi, M.; Bosco, D.; Vallino, M.; Abba, S.; Molinatto, G.; Palmano, S.; Balestrini, R.; Galetto, L.; Marzachi, C.
10.1101/2020.03.31.018010 — microbiology — Posted on 2020-04-06
3869 Antibiotics shift the temperature response curve of Escherichia coli growth
Cruz-Loya, M.; Tekin, E.; Kang, T. M.; Rodriguez-Verdugo, A.; Savage, V. M.; Yeh, P.
10.1101/2020.04.04.025874 — ecology — Posted on 2020-04-06
3870 CD19-targeting CAR T cells potently redirected to kill solid tumor cells
Ambrose, C.; Su, L.; Wu, L.; Dufort, F. J.; Stanford, T.; Birt, A.; Hackel, B. J.; Hombach, A. A.; Abken, H.; Lobb, R. R.; Rennert, P. D.
10.1101/2020.03.25.007658 — cancer biology — Posted on 2020-04-06
3871 Dietary vs non-dietary fatty acid profiles of lake trout ecotypes from Lake Superior and Great Bear Lake: Are fish really what they eat?
Chavarie, L.; Hoffmann, J.; Muir, A.; Krueger, C.; Bronte, C.; Howland, K.; Gallagher, C.; Sitar, S.; Hansen, M.; Vinson, M.; Loseto, L.; Tonn, W.; Swanson, H.
10.1101/714352 — ecology — Posted on 2020-04-06
3873 Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics
Araki, M.; Matsumoto, S.; Bekker, G.-J.; Isaka, Y.; Sagae, Y.; Kamiya, N.; Okuno, Y.
10.1101/2020.04.06.026930 — biophysics — Posted on 2020-04-06
3878 The circadian hippocampus and its reprogramming in epilepsy: impact for chronotherapeutics
Debski, K.; Ceglia, N.; Ghestem, A.; Ivanov, A.; Brancati, G. E.; Broer, S.; Bot, A.; Muller, A.; Schoch, S.; Becker, A.; Loscher, W.; Guye, M.; Sassone-Corsi, P.; Lukasiuk, K.; Baldi, P.; Bernard, C.
10.1101/199372 — neuroscience — Posted on 2020-04-06
3880 Jekyll or Hyde? The genome (and more) of Nesidiocoris tenuis, a zoophytophagous predatory bug that is both a biological control agent and a pest
Ferguson, K. B.; Visser, S.; Dalikova, M.; Provaznikova, I.; Urbaneja, A.; Perez-Hedo, M.; Marec, F.; Werren, J.; Zwaan, B. J.; Pannebakker, B. A.; Verhulst, E. C.
10.1101/2020.02.27.967943 — genomics — Posted on 2020-04-06
3881 A molecular approach to studying Hymenoptera diets using polistine wasps
Lefort, M.-C.; Beggs, J. R.; Glare, T. R.; Saunders, T. E.; Doyle, E. J.; Stephane, B.
10.1101/2020.04.06.024422 — ecology — Posted on 2020-04-06
3883 ID4 represses myoepithelial differentiation of mammary stem cells through its interaction with HEB
Holliday, H.; Roden, D. L.; Junankar, S.; Wu, S. Z.; Baker, L. A.; Krisp, C.; Chan, C.-L.; McFarland, A.; Skhinas, J. N.; Cox, T. R.; Pal, B.; Huntington, N.; Ormandy, C. J.; Carroll, J.; Visvader, J.; Molloy, M. P.; Swarbrick, A.
10.1101/2020.04.06.026963 — developmental biology — Posted on 2020-04-06
3884 Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts
Berdiel, M.; Maia, A.; Hristova, Z.; Borgoni, S.; Vetter, M.; Burmester, S.; Becki, C.; Abnaof, K.; Binenbaum, I.; Bethmann, D.; Chatziioannou, A.; Hasmann, M.; Thomssen, C.; Espinet, E.; Wiemann, S.
10.1101/2020.04.06.026971 — cancer biology — Posted on 2020-04-06
3885 Fast multi-directional DSLM for confocaldetection without striping artifacts
Ricci, P.; Sancataldo, G.; Gavryusev, V.; Franceschini, A.; Muellenbroich, C.; Silvestri, L.; Pavone, F. S.
10.1101/2020.04.06.027037 — biophysics — Posted on 2020-04-06
3887 DNA Thermo-Protection Facilitates Whole Genome Sequencing of Mycobacteria Direct from Clinical Samples by the Nanopore Platform
George, S.; Xu, Y.; Rodger, G.; Morgan, M.; Sanderson, N. D.; Hoosdally, S.; Thulborn, S.; Robinson, E.; Rathod, P.; Walker, A. S.; Peto, T. E.; Crook, D. W.; Dingle, K. E.
10.1101/2020.04.05.026864 — microbiology — Posted on 2020-04-06
3893 Microbial dark matter driven degradation of carbon fiber polymer composites
Breister, A. M.; Imam, M. A.; Zhou, Z.; Anantharaman, K.; Prabhakar, P.
10.1101/2020.04.05.024463 — microbiology — Posted on 2020-04-06
3896 Pacific Biosciences long reads-based genome sequencing data from a widespread bee fungal parasite, Nosema ceranae
chen, H.; Zhang, W.; Du, Y.; Fan, X.; Wang, J.; Jiang, H.; Fan, Y.; Zhu, Z.; Xiong, C.; Zheng, Y.; Chen, D.; Guo, R.
10.1101/2020.04.05.026849 — bioinformatics — Posted on 2020-04-06
3897 Sexual dimorphism and sex ratio bias in the dioecious willow Salix purpurea L.
Gouker, F. E.; Carlson, C. H.; Zou, J.; Evans, L. M.; Crowell, C. R.; Smart, C. D.; DiFazio, S. P.; Smart, L. B.
10.1101/2020.04.05.026427 — plant biology — Posted on 2020-04-06
3902 Mutational profiling of micro-dissected pre-malignant lesions from archived specimens
Nachmanson, D.; Steward, J.; Yao, H.; Jeong, E.; O'Keefe, T. J.; Hasteh, F.; Jepsen, K.; Hirst, G. L.; Esserman, L. J.; Borowsky, A. D.; Harismendy, O.
10.1101/2020.04.05.026708 — genomics — Posted on 2020-04-06
3905 Za2 domain of ZBP1 is a molecular switch regulating Influenza-induced PANoptosis and perinatal lethality during development
Kesavardhana, S.; Malireddi, R. K. S.; Burton, A.; Porter, S. N.; Vogel, P.; Pruett-Miller, S. M.; Kanneganti, T.-D.
10.1101/2020.04.05.026542 — immunology — Posted on 2020-04-06
3907 Systematically gap-filling the genome-scale model of CHO cells
Fouladiha, H.; Marashi, S.-A.; Li, S.; Li, Z.; Masson, H. O.; Vaziri, B.; Lewis, N. E.
10.1101/2020.01.27.921296 — systems biology — Posted on 2020-04-05
3909 RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese mice
Duggan, B. M.; Cavallari, J. F.; Foley, K. P.; Barra, N. G.; Schertzer, J. D.
10.1101/2020.04.03.024620 — physiology — Posted on 2020-04-05
3910 Molecular characterization of selectively vulnerable neurons in Alzheimer's Disease
Leng, K.; Li, E.; Eser, R.; Piergies, A.; Sit, R.; Tan, M.; Neff, N.; Li, S. H.; Diehl Rodriguez, R.; Suemoto, C. K.; Paraizo Leite, R. E.; Pasqualucci, C. A.; Seeley, W. W.; Spina, S.; Heinsen, H.; Grinberg, L. T.; Kampmann, M.
10.1101/2020.04.04.025825 — neuroscience — Posted on 2020-04-05
3911 Dopamine modulates prediction error forwarding in the nonlemniscal inferior colliculus
Valdes-Baizabal, C.; Carbajal, G. V.; Perez-Gonzalez, D.; Malmierca, M. S.
10.1101/824656 — neuroscience — Posted on 2020-04-06
3912 Structure of intact human MCU supercomplex with the auxiliary MICU subunits
Zhuo, W.; Zhou, H.; Guo, R.; Yi, J.; Yu, L.; Sui, Y.; Zhang, L.; Zeng, W.; Wang, P.; Yang, M.
10.1101/2020.04.04.025205 — molecular biology — Posted on 2020-04-06
3914 Chromatin dynamics during hematopoiesis reveal discrete regulatory modules instructing differentiation
Georgolopoulos, G.; Iwata, M.; Psatha, N.; Nishida, A.; Som, T.; Yiangou, M.; Stamatoyannopoulos, J. A.; Vierstra, J.
10.1101/2020.04.02.022566 — developmental biology — Posted on 2020-04-06
3918 The Mechanism of MICU-Dependent Gating of theMitochondrial Ca2+ Uniporter
Garg, V.; Paranjpe, I.; Unsulangi, T.; Suzuki, J.; Milescu, L. S.; Kirichok, Y.
10.1101/2020.04.04.025833 — biophysics — Posted on 2020-04-06
3919 H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
Cai, Y.; Zhang, Y.; Loh, Y. P.; Tng, J. Q.; Lim, M. C.; Cao, Z.; Raju, A.; Li, S.; Manikandan, L.; Tergaonkar, V.; Tucker-Kellogg, G.; Fullwood, M. J.
10.1101/684712 — genomics — Posted on 2020-04-05
3920 Concerted localization resets precede YAP-dependent transcription
Ghosh, R. P.; Franklin, J. M.; Shi, Q.; Reddick, M. P.; Liphardt, J. T.
10.1101/539049 — biophysics — Posted on 2020-04-05
3921 OptiFlex: video-based animal pose estimation using deep learning enhanced by optical flow
Liu, X.; Yu, S.-y.; Flierman, N.; Loyola, S.; Kamermans, M.; Hoogland, T. M.; De Zeeuw, C. I.
10.1101/2020.04.04.025494 — animal behavior and cognition — Posted on 2020-04-05
3922 HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence
Sofiadis, K.; Nikolic, M.; Kargapolova, Y.; Josipovic, N.; Zirkel, A.; Papadakis, A.; Papadionysiou, I.; Loughran, G.; Keane, J.; Michel, A.; Gusmao, E.; Mizi, A.; Georgomanolis, T.; Altmueller, J.; Nuernberg, P.; Beyer, A.; Papantonis, A.
10.1101/540146 — genomics — Posted on 2020-04-05
3924 Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy
Xin, J.; Li, Y.; Liu, H.-X.; Li, J.; Yang, G.; Zhang, H.; Wang, J.; Tong, R.; Wei, D.; Yao, Y.-F.
10.1101/2020.04.05.026252 — biophysics — Posted on 2020-04-05
3928 Multi-organ transcriptomic profiling reveals differential regulation of the immune system among the brain-liver-fats organ network of short-term fasted mice
Huang, S. S.; Makhlouf, M.; AbouMoussa, E. H.; Ruiz Tejada Segura, M. L.; Mathew, L. S.; Wang, K.; Leung, M. C.; Chaussabel, D.; Logan, D. W.; Scialdone, A.; Garand, M.; Saraiva, L. R.
10.1101/2020.04.05.026351 — systems biology — Posted on 2020-04-05
3930 LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2
Zhao, X.; Zheng, S.; Chen, D.; Zheng, M.; Li, X.; Li, G.; Lin, H.; Chang, J.; Zeng, H.; Guo, J.-T.
10.1101/2020.04.02.021469 — microbiology — Posted on 2020-04-05
3931 Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production
Fintelman-Rodrigues, N.; Sacramento, C. Q.; Ribeiro Lima, C.; Souza da Silva, F.; Ferreira, A.; Mattos, M.; de Freitas, C. S.; Cardoso Soares, V.; da Silva Gomes Dias, S.; Temerozo, J. R.; Miranda, M.; Matos, A. R.; Bozza, F. A.; Carels, N.; Roberto Alves, C.; Siqueira, M. M.; Bozza, P. T.; Souza, T. M. L.
10.1101/2020.04.04.020925 — microbiology — Posted on 2020-04-05
3936 Genetic diversity of Anopheles coustani in high malaria transmission foci in southern and central Africa
Ciubotariu, I. I.; Jones, C. M.; Kobayashi, T.; Bobanga, T.; Muleba, M.; Pringle, J. C.; Stevenson, J. C.; Carpi, G.; Norris, D. E.
10.1101/2020.04.04.020537 — evolutionary biology — Posted on 2020-04-05
3937 Community assembly as a basis for tropical forest restoration in a global change scenario
Meira-Neto, J.; Oliveira-Junior, N.; Silva, N.; Oliveira-filho, A. t.; bueno, m.; Pontara, V.; Gastauer, M.
10.1101/2020.04.04.022400 — ecology — Posted on 2020-04-05
3938 Exploration of target spaces in the human genome for protein and peptide drugs
Liu, Z.; Li, H.; Jin, Z.; Li, Y.; Guo, F.; He, Y.; Liu, X.; Li, D.; He, F.
10.1101/2020.04.05.026112 — bioinformatics — Posted on 2020-04-05
3939 Deep whole genome sequencing of multiple proband tissues and parental blood reveals the complex genetic etiology of congenital diaphragmatic hernias
Bogenschutz, E. L.; Fox, Z. D.; Farrell, A.; Wynn, J.; Moore, B.; Yu, L.; Aspelund, G.; Yandell, M. Y.; Shen, Y.; Chung, W. K.; Kardon, G.
10.1101/2020.04.03.024398 — genetics — Posted on 2020-04-05
3941 Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptor
York, H.; Patil, A.; Moorthi, U. K.; Kaur, A.; Bhowmik, A.; Hyde, G. J.; Gandhi, H.; Gaus, K.; Arumugam, S.
10.1101/481796 — cell biology — Posted on 2020-04-05
3942 Rapid community-driven development of a SARS-CoV-2 tissue simulator
Wang, Y.; Heiland, R.; Craig, M.; Davis, C. L.; Ford Versypt, A. N.; Jenner, A.; Ozik, J.; Collier, N.; Cockrell, C.; Becker, A.; An, G.; Glazier, J. A.; Narayanan, A.; Smith, A. M.; Macklin, P.
10.1101/2020.04.02.019075 — systems biology — Posted on 2020-04-05
3945 SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles
Bojkova, D.; McGreig, J. E.; McLaughlin, K.-M.; Masterson, S. G.; Widera, M.; Kraehling, V.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J. N.
10.1101/2020.04.03.024257 — microbiology — Posted on 2020-04-05
3952 Triphosphates of the Two Components in DESCOVY and TRUVADA are Inhibitors of the SARS-CoV-2 Polymerase
Jockusch, S.; Tao, C.; Li, X.; Anderson, T. K.; Chien, M.; Kumar, S.; Russo, J. J.; Kirchdoerfer, R.; Ju, J.
10.1101/2020.04.03.022939 — pharmacology and toxicology — Posted on 2020-04-05
3955 Interpretable machine learning framework reveals novel gut microbiome features in predicting type 2 diabetes
Gou, W.; Ling, C.-w.; Jiang, Z.; He, Y.; Fu, Y.; XU, F.; Miao, Z.; Sun, T.-y.; Lin, J.-s.; Zhu, H.-l.; Zhou, H.; Chen, Y.-m.; Zheng, J.-S.
10.1101/2020.04.05.024984 — microbiology — Posted on 2020-04-05
3958 Can biomass distribution across trophic levels predict trophic cascades?
Galiana, N.; Arnoldi, J.-F.; Barbier, M.; Acloque, A.; de Manzancourt, C.; Loreau, M.
10.1101/2020.04.04.025460 — ecology — Posted on 2020-04-05
3960 A Lysate Proteome Engineering Strategy for Enhancing Cell-Free Metabolite Production
Garcia, D. C.; Dinglasan, J. L. N.; Shresta, H. K.; Abraham, P.; Hettich, R. L.; Doktycz, M. J.
10.1101/2020.04.05.026393 — synthetic biology — Posted on 2020-04-05
3965 A Penicillium rubens platform strain for secondary metabolite production
Pohl, C.; Polli, F.; Schuetze, T.; Viggiano, A.; Mozsik, L.; Jung, S.; de Vries, M.; Meyer, V.; Bovenberg, R. A. L.; Driessen, A. J. M.
10.1101/2020.04.05.026286 — synthetic biology — Posted on 2020-04-05
3967 Maternal Continuous Oral Oxycodone Self-Administration Alters Pup Affective/Social Communication but not Spatial Learning or Sensory-Motor Function
Zanni, G.; Robinson-Drummer, P. A.; Dougher, D. A.; Deutsch, H. M.; DeSalle, M. J.; Teplitsky, D.; Vemulapalli, A.; Sullivan, R. M.; Eisch, A. J.; Barr, G. A.
10.1101/2020.04.04.022533 — pharmacology and toxicology — Posted on 2020-04-05
3969 Pyridoxal Kinase Inhibition by Artemisinins Downregulates Inhibitory Neurotransmission
Kasaragod, V. B.; Pacios-Michelena, A.; Schaefer, N.; Zheng, F.; Bader, N.; Alzheimer, C.; Villmann, C.; Schindelin, H.
10.1101/2020.04.05.026310 — neuroscience — Posted on 2020-04-05
3970 Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity
Lang, Y.; Li, W.; Li, Z.; Koerhuis, D.; van den Burg, A. C. S.; Rozemuller, E.; Bosch, B.-J.; van Kuppeveld, F. J. M.; Boons, G.-J. P. H.; Huizinga, E. G.; van der Schaar, H. M.; de Groot, R. J.
10.1101/2020.04.03.003699 — microbiology — Posted on 2020-04-05
3971 In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication
Touret, F.; Gilles, M.; Barral, K.; Nougairede, A.; Decroly, E.; de Lamballerie, X.; Coutard, B.
10.1101/2020.04.03.023846 — microbiology — Posted on 2020-04-05
3973 Elucidating the signatures of proteasome-catalysed peptide splicing
Paes, W.; Leonov, G.; Partridge, T.; Nicastri, A.; Ternette, N.; Borrow, P.
10.1101/2020.04.05.025908 — immunology — Posted on 2020-04-05
3974 Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.
Hannon, E.; Dempster, E.; Mansell, G.; Burrage, J.; Bass, N.; Bohlken, M.; Corvin, A.; Curtis, C.; Dempster, D.; Di Forta, M.; Dinan, T.; Donohoe, G.; Gaughran, F.; Gill, M.; Gillespie, A.; Gunasinghe, C.; Hulshoff, H.; Hultman, C.; Johansson, V.; Kahn, R.; Kaprio, J.; Kenis, G.; Kowalec, K.; MacCabe, J.; McDonald, C.; McQuillin, A.; Morris, D.; Murphy, K.; Mustard, C.; Nenadic, I.; O'Donovan, M.; Quattrone, D.; Richards, A.; Rutten, B.; St. Clair, D.; Therman, S.; Toulopoulou, T.; Van Os, J.; Waddington, J.; Wellcome Trust Case Control Consortium 2, ; CRESTAR Consortium, ; Sullivan, P.; Bre
10.1101/2020.04.05.026211 — genomics — Posted on 2020-04-05
3975 Thermal adaptation rather than demographic history drives genetic structure inferred by copy number variants in a marine fish
Cayuela, H.; Dorant, Y.; Merot, C.; Laporte, M.; Normandeau, E.; Gagnon-Harvey, S.; Sirois, P.; Bernatchez, L.
10.1101/2020.04.05.026443 — genomics — Posted on 2020-04-05
3979 Signaling mechanism of phytochromes in solution
Gustavsson, E.; Isaksson, L.; Persson, C.; Brath, U.; Karlsson, G.; Orekhov, V.; Westenhoff, S.
10.1101/2020.04.05.025882 — biochemistry — Posted on 2020-04-05
3980 Citrus vascular proteomics highlights the role of peroxidases and serine proteases during Huanglongbing disease progression
Franco, J.; Thapa, S. P.; Pang, Z.; Gurung, F. B.; Liebrand, T. W.; Stevens, D. M.; Ancona, V.; Wang, N.; Coaker, G.
10.1101/2020.04.05.025718 — plant biology — Posted on 2020-04-05
3981 A molecular filter for the cnidarian stinging response
Weir, K.; Dupre, C.; van Giesen, L.; Lee, A. S.; Bellono, N. W.
10.1101/2020.04.04.025338 — physiology — Posted on 2020-04-05
3983 On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias
Tian, X.; Moreira Leite, D.; Scarpa, E.; Nyberg, S.; Fullstone, G.; Forth, J.; Lourenco Matias, D.; Apriceno, A.; Poma, A.; Duro Castano, A.; Vuyyuru, M.; Harker-Kirschneck, L.; Saric, A.; Zhang, Z.; Xiang, P.; Fang, B.; Tian, Y.; Luo, L.; Rizzello, L.; Battaglia, G.
10.1101/2020.04.04.025866 — neuroscience — Posted on 2020-04-05
3984 Reward impacts visual statistical learning
Park, S. H.; Rogers, L. L.; Johnson, M. R.; Vickery, T. J.
10.1101/2020.04.04.025668 — neuroscience — Posted on 2020-04-05
3985 Molecular characterization of selectively vulnerable neurons in Alzheimer's Disease
Leng, K.; Li, E.; Eser, R.; Piergies, A.; Sit, R.; Tan, M.; Neff, N.; Li, S. H.; Diehl Rodriguez, R.; Suemoto, C. K.; Paraizo Leite, R. E.; Pasqualucci, C. A.; Seeley, W. W.; Spina, S.; Heinsen, H.; Grinberg, L. T.; Kampmann, M. T.
10.1101/2020.04.04.025825 — neuroscience — Posted on 2020-04-05
3987 Synchronized infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
Chakraborty, A.; Ko, C.; Henning, C.; Lucko, A.; Zhuang, X.; Wettengel, J. M.; Protzer, U.; McKeating, J. A.
10.1101/2020.04.05.026237 — microbiology — Posted on 2020-04-05
3989 OptiFlex: video-based animal pose estimation using deep learning enhanced by optical flow
Liu, X.; Yu, S.-y.; Flierman, N.; Loyola, S.; Kamermans, M.; Hoogland, T. M.; De Zeeuw, C. I.
10.1101/2020.04.04.025494 — animal behavior and cognition — Posted on 2020-04-05
3990 ANTITUMOR SULFATED POLYSACCHARIDES FROM BROWN ALGAE Dictyota caribaea
Assef, A. N. B.; Costa, B. B.; Moreira, T. A.; Carmo, L. D.; Souza, T. d. F. G.; Alencar, N. M. N.; Alves, A. P. N. N.; Cinelli, L. P.; Wilke, D. V.
10.1101/2020.04.04.025320 — pharmacology and toxicology — Posted on 2020-04-05
3992 Action-based organization and function of cerebellar cortical microcircuits
Cerminara, N. L.; Garwicz, M.; Darch, H.; Houghton, C. J.; Marple-Horvat, D. E.; Apps, R.
10.1101/2020.04.04.025387 — neuroscience — Posted on 2020-04-05
3995 Automatic subtyping of individuals with Primary Progressive Aphasia
Themistocleous, C.; Ficek, B.; Webster, K.; den Ouden, D.-B.; Hillis, A. E.; Tsapkini, K.
10.1101/2020.04.04.025593 — neuroscience — Posted on 2020-04-05
3997 Abundantly expressed class of non-coding RNAs conserved through the multicellular evolution of dictyostelid social amoebae
Kjellin, J.; Avesson, L.; Reimegard, J.; Liao, Z.; Eichinger, L.; Noegel, A.; Glöckner, G.; Schaap, P.; Söderbom, F.
10.1101/2020.04.05.026054 — evolutionary biology — Posted on 2020-04-05
3998 Cell-free synthesis of natural compounds from genomic DNA of biosynthetic gene clusters
Siebels, I.; Nowak, S.; Heil, C. S.; Tufar, P.; Cortina, N. S.; Bode, H. B.; Grininger, M.
10.1101/2020.04.04.025353 — bioengineering — Posted on 2020-04-05
3999 Detecting fine and elaborate movements with piezo sensors, from heartbeat to the temporal organization of behavior
Carreno-Munoz, M. I.; Medrano, M. C.; Leinekugel, T.; Bompart, M.; Martins, F.; Subashi, E.; Miguelez, C.; Aby, F.; Frick, A.; Landry, M.; Grana, M.; Leinekugel, X.
10.1101/2020.04.03.024711 — animal behavior and cognition — Posted on 2020-04-05
4002 Common Fronto-temporal Effective Connectivity in Humans and Monkeys
Rocchi, F.; Oya, H.; Balezeau, F.; Billig, A. J.; Kocsis, Z.; Jenison, R.; Nourski, K. V.; Kovach, C. K.; Steinschneider, M.; Kikuchi, Y.; Rhone, A. E.; Dlouhy, B. J.; Kawasaki, H.; Adolphs, R.; Greenlee, J. D. W.; Griffiths, T. D.; Howard, M. A.; Petkov, C. I.
10.1101/2020.04.03.024042 — neuroscience — Posted on 2020-04-05
4003 Functional and Pharmacological Evaluation of a Novel SCN2A Variant Linked to Early-onset Epilepsy
Adney, S. K.; Millichap, J. J.; DeKeyser, J.-M. L.; Abramova, T.; Thompson, C. H.; George, A. L.
10.1101/2020.04.03.024489 — neuroscience — Posted on 2020-04-05
4004 A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease
Hendrickx, D. M.; Garcia, P.; Ashrafi, A.; Sciortino, A.; Schmit, K. J.; Kollmus, H.; Nicot, N.; Kaoma, T.; Vallar, L.; Buttini, M.; Glaab, E.
10.1101/2020.04.04.016642 — neuroscience — Posted on 2020-04-05
4005 Face selective patches in marmoset frontal cortex
Schaeffer, D. J.; Selvanayagam, J.; Johnston, K. D.; Menon, R. S.; Freiwald, W. A.; Everling, S.
10.1101/2020.04.03.023960 — neuroscience — Posted on 2020-04-05
4009 Dopaminergic modulation of reward discounting: a systematic review and meta-analysis
Castrellon, J. J.; Meade, J.; Greenwald, L.; Hurst, K.; Samanez-Larkin, G. R.
10.1101/2020.04.03.024364 — neuroscience — Posted on 2020-04-05
4011 Neuronal kinase SGK1.1 protects against brain damage after status epilepticus
Martin-Batista, E.; Maglio, L. E.; Armas-Capote, N.; Hernandez, G.; Alvarez de la Rosa, D.; Giraldez, T.
10.1101/2020.04.03.024067 — neuroscience — Posted on 2020-04-05
4012 Analytical Validation of a COVID-19 qRT-PCR Detection Assay Using a 384-well Format and Three Extraction Methods
Nelson, A. C.; Auch, B.; Schomaker, M.; Gohl, D. M.; Grady, P.; Johnson, D.; Kincaid, R.; Karnuth, K. E.; Daniel, J.; Fiege, J. K.; Fay, E. J.; Bold, T.; Langlois, R. A.; Beckman, K. B.; Yohe, S.
10.1101/2020.04.02.022186 — pathology — Posted on 2020-04-05
4013 Neural control of steering in walking Drosophila
Rayshubskiy, A.; Holtz, S. L.; D'Alessandro, I.; Li, A. A.; Vanderbeck, Q. X.; Haber, I. S.; Gibb, P. W.; Wilson, R. I.
10.1101/2020.04.04.024703 — neuroscience — Posted on 2020-04-05
4014 A far-red fluorescent chemogenetic reporter for in vivo molecular imaging
Li, C.; Tebo, A. G.; Thauvin, M.; Plamont, M.-A.; Volovitch, M.; Morin, X.; Vriz, S.; Gautier, A.
10.1101/2020.04.04.022145 — molecular biology — Posted on 2020-04-05
4015 Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes
Kuil, L. E.; Oosterhof, N.; Ferrero, G.; mikulasova, T.; Hason, M.; Dekker, J.; Rovira, M.; van der Linde, H.; van Strien, P.; de Pater, E.; Schaaf, G.; Bindels, E.; Wittamer, V.; van Ham, T. J.
10.1101/2020.04.04.025585 — developmental biology — Posted on 2020-04-05
4017 Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo
Zeng, C.; Hou, X.; Yan, J.; Zhang, C.; Li, W.; Zhao, W.; Du, S.; Dong, Y.
10.1101/2020.04.01.019877 — bioengineering — Posted on 2020-04-05
4019 The Mechanism of MICU-Dependent Gating of theMitochondrial Ca2+ Uniporter
Garg, V.; Paranjpe, I.; Unsulangi, T.; Suzuki, J.; Milescu, L. S.; Kirichok, Y.
10.1101/2020.04.04.025833 — biophysics — Posted on 2020-04-05
4025 Multi-fluorescence high-resolution episcopic microscopy (MF-HREM) for three dimensional imaging of adult murine organs
Walsh, C.; Holroyd, N.; Finnerty, E.; Ryan, S. G.; Sweeney, P. W.; Shipley, R. J.; Walker-Samuel, S.
10.1101/2020.04.03.023978 — biophysics — Posted on 2020-04-05
4027 TMEM70 promotes ATP synthase assembly within cristae via transient interactions with subunit c
Bahri, H.; Buratto, J.; Rojo, M.; Dompierre, J. P.; Salin, B.; Blancard, C.; Cuvellier, S.; Rose, M.; Ben Ammar Elgaaied, A.; Tetaud, E.; di Rago, J.-P.; Devin, A.; Duvezin-Caubet, S.
10.1101/2020.04.03.023861 — cell biology — Posted on 2020-04-05
4028 ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming
Li, F.; Yuan, Q.; Di, W.; Xia, X.; Liu, Z.; Mao, N.; Li, L.; Li, C.; He, J.; Li, Y.; Guo, W.; Zhang, X.; Zhu, Y.; Aji, R.; Wang, S.; Chi, P.; Carver, B.; Wang, Y.; Chen, Y.; Gao, D.
10.1101/2020.04.03.024349 — cancer biology — Posted on 2020-04-05
4029 Machine Classification of Methylomes in Cancer
Newsham, I.; Sendera, M.; Jammula, S.; Fitzgerald, R.; Massie, C.; Samarajiwa, S. A.
10.1101/2020.04.04.025155 — bioinformatics — Posted on 2020-04-05
4030 Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation
Grieve, A. G.; Yeh, Y.-C.; Zarcone, L.; Breuning, J.; Johnson, N.; Strisovsky, K.; Brown, M. H.; Parekh, A. B.; Freeman, M.
10.1101/2020.04.04.025262 — biochemistry — Posted on 2020-04-05
4031 Engineering multiple species-like genetic incompatibilities in insects
Maselko, M.; Feltman, N.; Upadhyay, A.; Hayward, A.; Das, S.; Myslicki, N.; Peterson, A. J.; O'Connor, M. B.; Smanski, M.
10.1101/2020.04.03.024588 — synthetic biology — Posted on 2020-04-05
4033 Activation of SnRK2 by the Raf-like kinase ARK represents a common mechanism of ABA response in embryophytes
Takezawa, D.; Islam, M.; Inoue, T.; Hiraide, M.; Khatun, N.; Jahan, A.; Kuwata, K.; Umezawa, T.; Yotsui, I.; Sakata, Y.
10.1101/2020.04.03.024448 — plant biology — Posted on 2020-04-05
4034 Non-opioid analgesia based on Gα signalling bias
Wall, M.; Hill, E.; Huckstepp, R.; Deganutti, G.; Leuenberger, M.; Preti, B.; Barkan, K.; Winfield, I.; Wei, H.; Imlach, W.; Dean, E.; Hume, C.; Hayward, S.; Oliver, J.; Zhao, F.-Y.; Spanswick, D.; Reynolds, C. A.; Lochner, M.; Ladds, G.; Frenguelli, B.
10.1101/2020.04.04.023945 — physiology — Posted on 2020-04-05
4035 RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese mice
Duggan, B. M.; Cavallari, J. F.; Foley, K. P.; Barra, N. G.; Schertzer, J. D.
10.1101/2020.04.03.024620 — physiology — Posted on 2020-04-05
4036 The spectral sensitivity of Drosophila photoreceptors
Sharkey, C. R.; Blanco, J.; Leibowitz, M. M.; Pinto-Benito, D.; Wardill, T. J.
10.1101/2020.04.03.024638 — neuroscience — Posted on 2020-04-05
4037 Structure of intact human MCU supercomplex with the auxiliary MICU subunits
Zhuo, W.; Zhou, H.; Guo, R.; Yi, J.; Yu, L.; Sui, Y.; Zhang, L.; Zeng, W.; Wang, P.; Yang, M.
10.1101/2020.04.04.025205 — molecular biology — Posted on 2020-04-05
4038 Orthogonal fluorescent chemogenetic reporters for multicolor imaging
Tebo, A. G.; Moeyaert, B.; Thauvin, M.; Carlon-Andres, I.; Bokën, D.; Volovitch, M.; Padilla-Parra, S.; Dedecker, P.; Vriz, S.; Gautier, A.
10.1101/2020.04.04.022111 — molecular biology — Posted on 2020-04-05
4041 The importance of the immunodominant CD8+ T cell epitope of Plasmodium berghei circumsporozoite protein in parasite- and vaccine-induced protection
Gibbins, M. P.; Mueller, K.; Liu, J.; Glover, M.; Putrianti, E.; Bauza, K.; Reyes-Sandoval, A.; Matuschewski, K.; Silvie, O.; Hafalla, J. C.
10.1101/2020.04.03.024539 — immunology — Posted on 2020-04-05
4043 Cells and gene expression programs in the adult human heart
Litvinukova, M.; Talavera-Lopez, C.; Maatz, H.; Reichart, D.; Worth, C. L.; Lindberg, E. L.; Kanda, M.; Polanski, K.; Fasouli, E. S.; Samari, S.; Roberts, K.; Tuck, E.; Heinig, M.; DeLaughter, D.; McDonough, B.; Wakimoto, H.; Gorham, J. M.; Nadelmann, E.; Mahbubani, K. T.; Saeb-Parsy, K.; Patone, G.; Boyle, J. J.; Zhang, H.; Zhang, H.; Viveiros, A.; Oudit, G.; Bayraktar, O.; Seidman, J. G.; Seidman, C.; Noseda, M.; Hubner, N.; Teichmann, S. A.
10.1101/2020.04.03.024075 — genomics — Posted on 2020-04-05
4046 Genetic architecture of a mutation's expressivity and penetrance
Schell, R.; Mullis, M. N.; Matsui, T.; Foree, R.; Ehrenreich, I. M.
10.1101/2020.04.03.024547 — genetics — Posted on 2020-04-05
4047 Estimating the effect-size of gene dosage on cognitive ability across the coding genome
Huguet, G.; Schramm, C.; Douard, E. A.; Tamer, P.; Main, A.; Monin, P.; England, J.; Jizi, K.; Renne, T.; Poirier, M.; Nowak, S.; Martin, C.-O.; Younis, N.; Knoth, I. S.; Jean Louis, M.; Saci, Z.; Auger, M.; Tihy, F.; Mathonnet, G.; Maftei, C.; Leveille, F.; Porteous, D.; Davies, G.; Redmond, P.; Harris, S. E.; Lemyre, E.; Schumann, G.; Bourgeron, T.; Pausova, Z.; Paus, T.; Karama, S.; Lippe, S.; Deary, I.; Almasy, L.; Labbe, A.; Glahn, D.; Greenwood, C. M.; Jacquemont, S.
10.1101/2020.04.03.024554 — genetics — Posted on 2020-04-05
4048 The evolution of red blood cell shape in a continental radiation of fishes
Martins, B. O.; Franco-Belussi, L.; Siqueira, M. S.; Fernandes, C. E.; Provete, D. B.
10.1101/2020.04.03.023994 — evolutionary biology — Posted on 2020-04-05
4049 Oncogene Regulated Release of Extracellular Vesicles
Kilinc, S.; Paisner, R.; Camarda, R.; Momcilovic, O.; Kohnz, R. A.; L'Etoile, N. D.; Perera, R. M.; Nomura, D. M.; Goga, A.
10.1101/2020.04.04.025726 — cell biology — Posted on 2020-04-05
4051 Characterization Of Yellow Root Cassava And Food Products: Investigation Of Cyanogenic Glycosides And Pro-Vitamin A
Odoemelam, C.; Percival, B.; Ahmad, Z.; Chang, M.-W.; Scholey, D.; Burton, E.; Okafor, P. N.; Wilson, P. B.
10.1101/2020.04.03.024224 — biochemistry — Posted on 2020-04-05
4052 Nectar-dwelling microbes of common tansy are attractive to its mosquito pollinator, Culex pipiens L.
Peach, D.; Carroll, C.; Meraj, S.; Galloway, E.; Balcita, A.; Coatsworth, H.; Young, N.; Uriel, Y.; Gries, R.; Lowenberger, C.; Moore, M.; Gries, G. J.
10.1101/2020.04.03.024380 — ecology — Posted on 2020-04-05
4053 Modular genetic control of social status in a cichlid fish
Alward, B. A.; Laud, V.; Skalnik, C. J.; York, R. A.; Juntti, S. A.; Fernald, R. D.
10.1101/2020.04.03.024190 — animal behavior and cognition — Posted on 2020-04-05
4064 Epigenomic Diversity of Cortical Projection Neurons in the Mouse Brain
Zhang, Z.; Zhou, J.; Tan, P.; Pang, Y.; Rivkin, A.; Kirchgessner, M. A.; Williams, E.; Lee, C.-T.; Liu, H.; Franklin, A. D.; Miyazaki, P. A.; Bartlett, A.; Aldridge, A.; Vu, M.; Boggeman, L.; Fitzpatrick, C.; Nery, J.; Castanon, R. G.; Rashid, M.; Jacobs, M.; Ito, T.; Dominguez, B.; Niu, S.-Y.; Smith, J. B.; O'Connor, C.; Lee, K.-F.; Jin, X.; Mukamel, E. A.; Behrens, M. M.; Ecker, J. R.; Callaway, E. M.
10.1101/2020.04.01.019612 — neuroscience — Posted on 2020-04-04
4067 Quantifying the dynamics of pig movements improves targeted disease surveillance and control plans
Machado, G.; Galvis, J. A.; Lopes, F. P. N.; Voges, J.; Medeiros, A. A. R.; Cardenas, N.
10.1101/2019.12.29.886408 — ecology — Posted on 2020-04-04
4069 SCAPP: An algorithm for improved plasmid assembly in metagenomes
Pellow, D.; Probst, M.; Furman, O.; Zorea, A.; Segal, A.; Mizrahi, I.; Shamir, R.
10.1101/2020.01.12.903252 — bioinformatics — Posted on 2020-04-04
4077 Phenotypic screening using synthetic CRISPR gRNAs reveals pro-regenerative genes in spinal cord injury
Keatinge, M.; Tsarouchas, T.; Munir, T.; Larraz, J.; Gianni, D.; Tsai, H.-H.; Becker, C. G.; Lyons, D.; Becker, T.
10.1101/2020.04.03.023119 — neuroscience — Posted on 2020-04-04
4078 Local and global dichotomic dysfunction in resting and evoked functional connectivity precedes tauopathy
Mandino, F.; Yeow, L. Y.; Bi, R.; Lee, S.; Bae, H. G.; Baek, S. H.; Lee, C. Y.; Mohammad, H.; Teoh, C. L.; Lee, J.; Lai, M. K. P.; Jung, S.; Yu, F.; Olivo, M.; Gigg, J.; Grandjean, J.
10.1101/2020.04.03.022590 — neuroscience — Posted on 2020-04-04
4079 Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter
Jia, R.; Martens, C.; Shekhar, M.; Pant, S.; Pellowe, G. A.; Lau, A. M.; Findlay, H. E.; Harris, N. J.; Tajkhorshid, E.; Booth, P. J.; Politis, A.
10.1101/2020.04.03.023564 — biochemistry — Posted on 2020-04-04
4081 Detecting genetic variation and base modifications together in the same single molecules of DNA and RNA at base pair resolution using a magnetic tweezer platform.
Wang, Z.; Maluenda, J.; Giraut, L.; Vieille, T.; Lefevre, A.; Salthouse, D.; Radou, G.; Moulinas, R.; Astete-Morales, S.; dAvezac, P.; Smith, G.; Andre, C.; Allemand, J.-F.; Bensimon, D.; Croquette, V.; Ouellet, J.; Hamilton, G.
10.1101/2020.04.03.002501 — genomics — Posted on 2020-04-04
4082 Genomic Epidemiology with Mixed Samples
Mäklin, T.; Kallonen, T.; Alanko, J.; Mäkinen, V.; Corander, J.; Honkela, A.
10.1101/2020.04.03.021501 — bioinformatics — Posted on 2020-04-04
4083 High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism
Dumitru, A.; Deepak, K. R. N. V.; Liu, H.; Koehler, M.; Zhang, C.; Fan, H.; Alsteens, D.
10.1101/2020.04.03.024018 — biochemistry — Posted on 2020-04-04
4084 High-resolution influenza mapping of a city reveals socioeconomic determinants of transmission within and between urban quarters
Egli, A.; Goldman, N.; Müller, N. F.; Brunner, M.; Wuethrich, D.; Tschudin-Sutter, S.; Hodcroft, E.; Neher, R.; Saalfrank, C.; Hadfield, J.; Bedfors, T.; Syedbasha, M.; Vogel, T.; Augustin, N.; Bauer, J.; Sailer, N.; Amar-Sliwad, N.; Lang, D.; Seth-Smith, H. M.; Blaich, A.; Hollenstein, Y.; Dubuis, O.; Naegele, M.; Buser, A.; Nickel, C.; Ritz, N.; Zeller, A.; Stadler, T.; Battegay, M.; Schneider-Sliwa, R.
10.1101/2020.04.03.023135 — microbiology — Posted on 2020-04-04
4085 TINC - a method to dissect transcriptional complexes at single locus resolution - reveals novel Nanog regulators in mouse embryonic stem cells
Knaupp, A. S.; Mohenska, M.; Larcombe, M. R.; Ford, E.; Lim, S. M.; Wong, K.; Chen, J.; Firas, J.; Huang, C.; Nguyen, T.; Sun, B.; Holmes, M. L.; Tripathi, P.; Rossello, F. J.; Schroeder, J.; Nefzger, C. M.; Das, P. P.; Haigh, J. J.; Lister, R.; Schittenhelm, R. B.; Polo, J. M.
10.1101/2020.04.03.023200 — genomics — Posted on 2020-04-04
4089 Functional maturation of the gut microbiota at weaning is influenced by maternal environment in piglets
Beaumont, M.; Cauquil, L.; Bertide, A.; Ahn, I.; Barilly, C.; Gill, L.; Canlet, C.; Zemb, O.; Pascal, G.; Samsom, A.; Combes, S.
10.1101/2020.04.02.022913 — microbiology — Posted on 2020-04-04
4090 The adaptive transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress
Zavala-Alvarado, C.; Sismeiro, O.; Legendre, R.; Varet, H.; Bussotti, G.; Bayram, J.; Garcia Huete, S.; Rey, G.; Coppee, J. Y.; Picardeau, M.; Benaroudj, N.
10.1101/2020.04.03.015982 — microbiology — Posted on 2020-04-04
4092 A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma
Curtin, L.; Hawkins-Daarud, A.; Porter, A. B.; van der Zee, K. G.; Owen, M. R.; Swanson, K. R.
10.1101/2020.04.03.022202 — cancer biology — Posted on 2020-04-04
4093 Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures
Karkampouna, S.; De Filippo, M. R.; Ng, C. Y.; Klima, I.; Zoni, E.; Spahn, M.; Stein, F.; Haberkant, P.; Thalmann, G. N.; Kruithof-de Julio, M.
10.1101/2020.04.03.018143 — cancer biology — Posted on 2020-04-04
4094 Obtusaquinone is a cysteine modifying compound that targets Keap1 for degradation
badr, c. E.; da Hora, C. C.; Kirov, A.; Amante, R.; Fitzsimons, E.; Chen, J. W.; Nibbs, A. E.; Nakano, I.; Tabet, E.; Chiu, N.; Haas, W.; Mazitschek, R.; Tannous, B. A.
10.1101/2020.04.03.023432 — cancer biology — Posted on 2020-04-04
4095 The primary donor of far-red Photosystem II: ChlD1 or PD2?
Judd, M.; Morton, J.; Nuernberg, D.; Fantuzzi, A.; Rutherford, A. W.; Purchase, R.; Cox, N.; Krausz, E.
10.1101/2020.04.03.021097 — biophysics — Posted on 2020-04-04
4096 Ratchetaxis in channels: cells move directionally by pushing walls asymmetrically.
Le Maout, E.; LO VECCHIO, S.; Kumar Korla, P.; Sheu, J. J.-C.; Riveline, D.
10.1101/2020.04.03.023051 — biophysics — Posted on 2020-04-04
4098 Real-time biomedical knowledge synthesis of the exponentially growing world wide web using unsupervised neural networks
Wagner, T.; Awasthi, S.; Wittenberg, G.; Venkatakrishnan, A.; Tarjan, D.; Anyanwu-Ofili, A.; Badley, A.; Halamka, J.; Flores, C.; Khan, N.; Barve, R.; Soundararajan, V.
10.1101/2020.04.03.020602 — bioinformatics — Posted on 2020-04-04
4099 Direct Electrical Detection of sub-aM DNA Concentrations
Guo, M.; Madaboosi, N.; Neumann, F.; Nilsson, M.; van der Wihngaart, W.
10.1101/2020.04.03.023176 — bioengineering — Posted on 2020-04-04
4100 Programmable RNA Targeting using CasRx in Flies
Buchman, A.; Brogan, D. J.; Sun, R.; Yang, T.; Hsu, P.; Akbari, O.
10.1101/2020.04.03.023606 — bioengineering — Posted on 2020-04-04
4103 Sleep spindles facilitate selective memory consolidation
Denis, D.; Mylonas, D.; Poskanzer, C.; Bursal, V.; Payne, J. D.; Stickgold, R.
10.1101/2020.04.03.022434 — neuroscience — Posted on 2020-04-04
4104 Addition of Multiple Introns to a Cas9 Gene Results in Dramatic Improvement in Efficiency for Generation of Gene Knockouts in Plants
Grützner, R.; Martin, P.; Horn, C.; Mortensen, S.; Cram, E. J.; Lee-Parsons, C. W. T.; Stuttmann, J.; Marillonnet, S.
10.1101/2020.04.03.023036 — molecular biology — Posted on 2020-04-04
4107 SimiC: A Single Cell Gene Regulatory Network Inference method with Similarity Constraints
Peng, J.; Chembazhi, U. V.; Bangru, S.; Traniello, I. M.; Kalsotra, A.; Ochoa, I.; Hernaez, M.
10.1101/2020.04.03.023002 — bioinformatics — Posted on 2020-04-04
4108 Maternal phylogenetic relationships and genetic variation among rare similar phenotype donkey breeds
MAZZATENTA, A.; Caputo, M.; De Sanctis, F.; Miro Roig, J.; Robbe, D.; Carluccio, A.
10.1101/2020.04.03.022921 — zoology — Posted on 2020-04-04
4109 The effect of noise trauma and high-frequency stimulation on thalamic sensory gating in rodents
Zare, A.; van Zwieten, G.; Kotz, S.; Temel, Y.; Schultz, B.; Schwartze, M.; Janssen, M.
10.1101/2020.04.03.023143 — neuroscience — Posted on 2020-04-04
4113 Non-Canonical Targets of HIF1a Drive Cell-Type-Specific Dysfunction
Allan, K. C.; Hu, L. R.; Morton, A. R.; Scavuzzo, M. A.; Gevorgyan, A. S.; Clayton, B. L. L.; Bederman, I.; Hung, S.; Bartels, C. F.; Madhavan, M.; Tesar, P. J.
10.1101/2020.04.03.003632 — developmental biology — Posted on 2020-04-04
4116 Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of Differentiation
Canu, G.; Athanasiadis, E.; Grandy, R. A.; Garcia-Bernardo, J.; Strzelecka, P. M.; Vallier, L.; Ortmann, D.; Cvejic, A.
10.1101/2020.04.03.023762 — developmental biology — Posted on 2020-04-04
4117 A Region of UNC-89 (obscurin) Lying Between Two Protein Kinase Domains is a Highly Elastic Spring Required for Proper Sarcomere Assembly
Qadota, H.; Moody, J. C.; Lesanpezeshki, L.; Moncrief, T.; Kitzler, D.; Bhat, P. D.; Vanapalli, S. A.; Oberhauser, A. F.; Benian, G. M.
10.1101/2020.04.03.023374 — cell biology — Posted on 2020-04-04
4118 Membrane Elastic Properties During Neural Progenitor/Neural Stem Cell Differentiation
Soares, J.; Araujo, G. R. d. S.; Santana, C.; Matias, D.; Moura-Neto, V.; Farina, M.; Frases, S.; Viana, N. B.; Romao, L.; Nussenzveig, H. M.; Pontes, B.
10.1101/2020.04.03.019950 — biophysics — Posted on 2020-04-04
4120 A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells
van de Moosdijk, A. A. A.; van de Grift, Y. B. C.; de Man, S. M. A.; Zeeman, A. L.; van Amerongen, R.
10.1101/2020.04.03.024182 — developmental biology — Posted on 2020-04-04
4123 Myosin VI moves on nuclear actin filaments and supports long-range chromatin rearrangements
Grosse-Berkenbusch, A.; Hettich, J.; Kuhn, T.; Fili, N.; Cook, A. W.; Hari-Gupta, Y.; Palmer, A.; Streit, L.; Ellis, P. J. I.; Toseland, C.; Gebhardt, J. C. M.
10.1101/2020.04.03.023614 — cell biology — Posted on 2020-04-04
4124 Focused ultrasound stimulates ER localized mechanosensitive PANNEXIN-1 to mediate intracellular calcium release in invasive cancer cells
Lee, N. S.; Yoon, C. W.; Wang, Q.; Moon, S.; Koo, K. M.; Jung, H. J.; Chen, R.; Jiang, L.; Lu, G.; Fernandez, A.; Chow, R. H.; Weitz, A. C.; Salvaterra, P. M. S. M.; Pinaud, F.; Shung, K. K.
10.1101/2020.04.03.024372 — cell biology — Posted on 2020-04-04
4126 Temporal Analysis of T-Cell Receptor-Imposed Forces via Quantitative Single Molecule FRET Measurements
Göhring, J.; Kellner, F.; Schrangl, L.; Platzer, R.; Klotzsch, E.; Stockinger, H.; Huppa, J. B.; Schuetz, G.
10.1101/2020.04.03.024299 — biophysics — Posted on 2020-04-04
4127 Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice
Rajeshkumar, N. V.; Yabuuchi, S.; Pai, S. G.; Maitra, A.; Hidalgo, M.; Dang, C. V.
10.1101/2020.03.31.018556 — pharmacology and toxicology — Posted on 2020-04-04
4129 Lack of Adipocyte Purinergic P2Y6 Receptor Greatly Improves Whole Body Glucose Homeostasis
Jain, S.; Pydi, S. P.; Toti, K. S.; Robaye, B.; Idzko, M.; Gavrilova, O.; Wess, J.; Jacobson, K. A.
10.1101/2020.04.03.023234 — physiology — Posted on 2020-04-04
4130 Nucleosome assembly and disassembly pathways.
Akiko, H.; Retureau, R.; Pasi, M.; Hartmann, B.; Claude, N.; Buckle, M.
10.1101/2020.04.01.020263 — molecular biology — Posted on 2020-04-04
4131 A bacterial tragedy of the commons that masks the actual frequency of mutants
Neves, H. I.; Trombini, G.; Ramos, T.; Yang, H. M.; Yagil, E.; Spira, B.
10.1101/2020.04.02.022889 — genetics — Posted on 2020-04-04
4132 Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptors
Neto, E.; Leitao, L.; Mateus, J.; Sousa, D.; Conceicao, F.; Alves, C. J.; Oreffo, R. O. C.; West, J.; Aguiar, P.; Lamghari, M.
10.1101/259218 — cell biology — Posted on 2020-04-04
4133 Hypoxia-related radiomics predict immunotherapy response: A multi-cohort study of NSCLC
Tunali, I.; Tan, Y.; Gray, J. E.; Katsoulakis, E.; Eschrich, S. A.; Saller, J.; Boyle, T.; Qi, J.; Guvenis, A.; Gillies, R. J.; Schabath, M. B.
10.1101/2020.04.02.020859 — bioinformatics — Posted on 2020-04-04
4134 Gene Deletion Studies Reveal A Critical Role For Prostamide/Prostaglandin F2α Synthase In Prostamide F2α Formation
Bertrand, J. A.; Woodward, D. F.; Sherwood, J. M.; Spenlehauer, A.; Silvestri, C.; Piscitelli, F.; Di Marzo, V.; Yamazaki, M.; Sakimura, K.; Watanabe, K.; Overby, D.
10.1101/2020.04.01.020768 — pharmacology and toxicology — Posted on 2020-04-04
4135 The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo
Bressan, C.; Pecora, A.; Gagnon, D.; Snapyan, M.; Labrecque, S.; De Koninck, P.; Parent, M.; Saghatelyan, A.
10.1101/2020.04.02.022228 — neuroscience — Posted on 2020-04-04
4136 Pod indehiscence in common bean is associated to the fine regulation of PvMYB26 and a non-functional abscission layer
Di Vittori, V.; Bitocchi, E.; Rodriguez, M.; Alseekh, S.; Bellucci, E.; Nanni, L.; Gioia, T.; Marzario, S.; Logozzo, G.; Rossato, M.; De Quattro, C.; Murgia, M. L.; Ferreira, J. J.; Campa, A.; Xu, C.; Fiorani, F.; Sampathkumar, A.; Fröhlich, A.; Attene, G.; Delledonne, M.; Usadel, B.; Fernie, A. R.; Rau, D.; Papa, R.
10.1101/2020.04.02.021972 — genetics — Posted on 2020-04-04
4137 Role of transmembrane helix 6 in substrate recognition of the amino acid transporter MhsT
Nissen, P.; Quick, M.; Blunck, R.; Lyons, J.; Neumann, C. M. T.; Focht, D.; Javitch, J. A.; Eguskiza, A.; Malinauskaite, L.; Schwarz, I. O.
10.1101/2020.04.03.022970 — biochemistry — Posted on 2020-04-04
4138 Mediator complex subunit Med19 binds directly GATA DNA-binding zinc finger and functions with Med1 in GATA-driven gene regulation in vivo
Immarigeon, C.; Bernat-Fabre, S.; Guillou, E.; Verger, A.; Prince, E.; Benmedjahed, M. A.; Payet, A.; Couralet, M.; Monte, D.; Villeret, V.; Bourbon, H.-M.; Boube, M.
10.1101/2020.04.03.023895 — developmental biology — Posted on 2020-04-04
4139 Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene
Forero, L. S.; Raymond, W.; Handa, T.; Saxton, M.; Morisaki, T.; Kimura, H.; Bertrand, E.; Munsky, B.; Stasevich, T. J.
10.1101/2020.04.03.024414 — molecular biology — Posted on 2020-04-04
4140 An oscillating MinD protein determines the cellular positioning of the motility machinery in archaea
Nussbaum, P.; Ithurbide, S.; Walsh, J. C.; Patro, M.; Delpech, F.; Rodriguez-Franco, M.; Curmi, P. M. G.; Duggin, I. G.; Quax, T. E. F.; Albers, S.-V.
10.1101/2020.04.03.021790 — microbiology — Posted on 2020-04-04
4141 3-Dimensional Organization and Dynamics of the Microsporidian Polar Tube Invasion Machinery
Jaroenlak, P.; Cammer, M.; Davydov, A.; Sall, J.; Usmani, M.; Liang, F.-X.; Ekiert, D. C.; Bhabha, G.
10.1101/2020.04.03.024240 — microbiology — Posted on 2020-04-04
4143 Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
Basu, S.; Shukron, O.; Ponjavic, A.; Parruto, P.; Boucher, W.; Zhang, W.; Reynolds, N.; Lando, D.; Shah, D.; Sober, L. H.; Jartseva, A.; Ragheb, R.; Cramard, J.; Floyd, R.; Brown, G.; Gor, K.; Balmer, J.; Drury, T. A.; Carr, A.; Needham, L.-M.; Aubert, A.; Communie, G.; Morey, L.; Blanco, E.; Barber, M. A.; Mohorianu, I.; Bartke, T.; Di Croce, L.; Berger, I.; Schaffitzel, C.; Lee, S.; Stevens, T. J.; Klenerman, D.; Hendrich, B.; Holcman, D.; Laue, E. D.
10.1101/2020.04.03.003178 — cell biology — Posted on 2020-04-04
4145 Regulation of gene drive expression increases invasive potential and mitigates resistance
Hammond, A. M.; Karlsson, X.; Morianou, I.; Kyrou, K.; Beaghton, A.; Gribble, M.; Kranjc, N.; Galizi, R.; Burt, A.; Crisanti, A.; Nolan, T.
10.1101/360339 — genetics — Posted on 2020-04-04
4146 Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)
Sojitra, M.; Sarkar, S.; Maghera, J.; Rodrigues, E.; Carpenter, E. J.; Seth, S.; Vinals, D. F.; Bennett, N. J.; Reddy, R.; Khalil, A.; Xue, X.; Bell, M.; Zheng, R. B.; Zhang, P.; Nycholat, C.; Ling, C. C.; Lowary, T. L.; Paulson, J. C.; Macauley, M. S.; Derda, R.
10.1101/2020.03.24.997536 — biochemistry — Posted on 2020-04-04
4147 Single cell RNA-Seq analysis identifies molecular mechanisms controlling hypothalamic patterning and differentiation.
Kim, D. W.; Washington, P. W.; Wang, Z. Q.; Lin, S.; Sun, C.; Ismali, B. T.; Wang, H.; Jiang, L.; Blackshaw, S.
10.1101/657148 — neuroscience — Posted on 2020-04-04
4150 Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
Bakken, T. E.; Jorstad, N. L.; Hu, Q.; Lake, B. B.; Tian, W.; Kalmbach, B. E.; Crow, M.; Hodge, R. D.; Krienen, F. M.; Sorensen, S. A.; Eggermont, J.; Yao, Z.; Aevermann, B. D.; Aldridge, A. I.; Bartlett, A.; Bertagnolli, D.; Casper, T.; Castanon, R. G.; Crichton, K.; Daigle, T. L.; Dalley, R.; Dee, N.; Dembrow, N.; Diep, D.; Ding, S.-L.; Dong, W.; Fang, R.; Fischer, S.; Goldman, M.; Goldy, J.; Graybuck, L. T.; Herb, B. R.; Hou, X.; Kancherla, J.; Kroll, M.; Lathia, K.; Lew, B. v.; Li, Y. E.; Liu, C. S.; Liu, H.; Lucero, J. D.; Mahurkar, A.; McMillen, D.; Miller, J. A.; Moussa, M.; Nery, J. R.
10.1101/2020.03.31.016972 — neuroscience — Posted on 2020-04-04
4151 Surveying Brain Tumor Heterogeneity by Single-Cell RNA Sequencing of Multi-sector Biopsies
Yu, K.; Hu, Y.; Wu, F.; Guo, Q.; Qian, Z.; Hu, W.; Chen, J.; Wang, K.; Fan, X.; Wu, X.; Rasko, J. E.; Fan, X.; Iavarone, A.; Jiang, T.; Tang, F.; Su, X.-D.
10.1101/2020.01.19.911701 — genomics — Posted on 2020-04-04
4152 Powerful detection of polygenic selection and environmental adaptation in US beef cattle populations
Rowan, T. N.; Durbin, H. J.; Nilson, S. M.; Seabury, C. M.; Schnabel, R. D.; Decker, J. E.
10.1101/2020.03.11.988121 — genomics — Posted on 2020-04-04
4154 Genomic diversity of Escherichia coli isolates from non-human primates in the Gambia
Foster-Nyarko, E.; Alikhan, N.-F.; Ravi, A.; Thilliez, G.; Thomson, N.; Cramer, J. D.; Baker, D.; Kay, G.; O'Grady, J.; Antonio, M.; PALLEN, M. J.
10.1101/2020.02.29.971309 — genomics — Posted on 2020-04-04
4155 Widefield light sheet microscopy using an Airy beam combined with deep-learning super-resolution
Corsetti, S.; Wijesinghe, P.; Poulton, P. B.; Sakata, S.; Vyas, K.; Herrington, C. S.; Nylk, J.; Gasparoli, F.; Dholakia, K.
10.1101/2020.02.27.967547 — biophysics — Posted on 2020-04-04
4156 In Silico Investigations on Curcuminoids from Curcuma longa as Positive Regulators of Wnt/β-catenin Signaling Pathway in Wound Healing
Reshad, R. A. I.; Alam, S.; Raihan, H. B.; Meem, K. N.; Rahman, F.; Zahid, F.; Rafid, M. I.; Rahman, S. M. O.; Omit, S.; Ali, M. H.
10.1101/2020.03.19.998286 — bioinformatics — Posted on 2020-04-04
4161 Fine-scale computations for adaptive processing in the human brain
Zamboni, E.; Kemper, V. G.; Goncalves, N. R.; Jia, K.; Karlaftis, V. M.; Bell, S. J.; Giorgio, J. J.; Rideaux, R.; Goebel, R.; Kourtzi, Z.
10.1101/2020.02.14.947895 — neuroscience — Posted on 2020-04-04
4162 Enhanced nutrient uptake is sufficient to drive emergent cross-feeding between bacteria
Fritts, R. K.; Bird, J. T.; Behringer, M. G.; Lipzen, A.; Martin, J.; Lynch, M.; McKinlay, J. B.
10.1101/770727 — microbiology — Posted on 2020-04-04
4163 CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries
Becker, M.; Noll-Puchta, H.; Amend, D.; Nolte, F.; Fuchs, C.; Jeremias, I. J.; Braun, C. J.
10.1101/2020.04.02.021279 — genomics — Posted on 2020-04-04
4164 Nuclear Lamins A/C and B1 Provide a Structural Framework That Organizes and Anchors Nuclear Pore Complexes
Kittisopikul, M.; Shimi, T.; Tatli, M.; Tran, J. R.; Zheng, Y.; Medalia, O.; Jaqaman, K.; Adam, S. A.; Goldman, R. D.
10.1101/2020.04.03.022798 — cell biology — Posted on 2020-04-04
4167 The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa
Vo, C.-D.-T.; Michaud, J.; Elsen, S.; Faivre, B.; Bouveret, E.; Barras, F.; Fontecave, M.; Pierrel, F.; Lombard, M.; Pelosi, L.
10.1101/2020.03.22.002311 — biochemistry — Posted on 2020-04-04
4169 Evaluation of DNA extraction protocols from liquid-based cytology specimens for studying cervical microbiota
Shibata, T.; Nakagawa, M.; Coleman, H. N.; Owens, S. M.; Greenfield, W. W.; Sasagawa, T.; Robeson, M. S.
10.1101/2020.01.27.921619 — microbiology — Posted on 2020-04-04
4170 Summer drought decreases the predictability of local extinctions in a butterfly metapopulation
van Bergen, E.; Dallas, T.; DiLeo, M. F.; Kahilainen, A.; Mattila, A. L. K.; Luoto, M.; Saastamoinen, M.
10.1101/863795 — ecology — Posted on 2020-04-04
4171 Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells
Kumar, R. J.; Chao, H. X.; Roberts, V. R.; Sullivan, A. R.; Shah, S. J.; Simpson, D. A.; Feng, W.; Wozny, A.-S.; Kumar, S.; Purvis, J. E.; Gupta, G. P.
10.1101/2020.04.01.021253 — cell biology — Posted on 2020-04-04
4172 Antimicrobial peptide induced-stress renders Staphylococcus aureus susceptible to toxic nucleoside analogues
Rodriguez-Rojas, A.; Nath, A.; El Shazely, B.; Santi, G.; Kim, J. J.; Weise, C.; Kuropka, B.; Rolff, J.
10.1101/2020.03.30.015206 — microbiology — Posted on 2020-04-04
4173 Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs
Do, C.; Dumont, E. L. P.; Salas, M.; Castano, A.; Mujahed, H.; Maldonado, L.; Singh, A.; Bhagat, G.; Lehman, S.; Christiano, A. M.; Madhavan, S.; Nagy, P. L.; Green, P. H. R.; Feinman, R.; Trimble, C.; Marder, K.; Honig, L.; Monk, C.; Goy, A.; Chow, K.; Goldlust, S.; Kaptain, G.; Siegel, D.; Tycko, B.
10.1101/815605 — genomics — Posted on 2020-04-04
4174 Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukemia
Deniz, O.; Ahmed, M.; Todd, C. D.; Rio-Machin, A.; Dawson, M. A.; Branco, M. R.
10.1101/772954 — genetics — Posted on 2020-04-04
4175 rapidPop: Rapid population assessments of wildlife using camera trap data in R Shiny Applications
Tabak, M. A.; Lewis, J. S.; Schlichting, P. E.; Snow, N. P.; VerCauteren, K. C.; Miller, R. S.
10.1101/2020.03.30.017103 — ecology — Posted on 2020-04-04
4176 Phase Transition of RNA-protein Complexes into Ordered Hollow Condensates
Alshareedah, I.; Moosa, M. M.; Raju, M.; Potoyan, D. A.; Banerjee, P. R.
10.1101/2020.01.10.902353 — biophysics — Posted on 2020-04-04
4177 On the discovery of population-specific state transitions from multi-sample multi-condition single-cell RNA sequencing data
Crowell, H. L.; Soneson, C.; Germain, P.-L.; Calini, D.; Collin, L.; Raposo, C.; Malhotra, D.; Robinson, M.
10.1101/713412 — bioinformatics — Posted on 2020-04-04
4178 Ibrutinib blocks YAP1 activation and reverses BRAFi resistance in melanoma cells
Misek, S. A.; Newbury, P. A.; Chekalin, E.; Paithankar, S.; Doseff, A. I.; Chen, B.; Gallo, K. A.; Neubig, R. R.
10.1101/2020.03.25.006916 — cancer biology — Posted on 2020-04-04
4179 Digitally Deconstructing Leaves in 3D Using X-ray Microcomputed Tomography and Machine Learning
Theroux-Rancourt, G.; Jenkins, M. R.; Brodersen, C. R.; McElrone, A.; Forrestel, E. J.; Earles, J. M.
10.1101/814954 — plant biology — Posted on 2020-04-04
4180 Bidirectional crosstalk between HIF and Glucocorticoid signalling in zebrafish larvae
Marchi, D.; Santhakumar, K.; Markham, E.; Li, N.; Storbeck, K.-H.; Krone, N.; Cunliffe, V. T.; van Eeden, F. J. M.
10.1101/748566 — physiology — Posted on 2020-04-04
4181 Modeling the short-term dynamics of in vivo excitatory spike transmission
Ghanbari, A.; Ren, N.; Keine, C.; Stoelzel, C.; Englitz, B.; Swadlow, H.; Stevenson, I.
10.1101/475178 — neuroscience — Posted on 2020-04-04
4183 Traces of transposable element in genome dark matter co-opted by flowering gene regulation networks.
Baud, A.; Wan, M.; Nouaud, D.; Francillonne, N.; Anxolabehere, D.; Quesneville, H.
10.1101/547877 — genomics — Posted on 2020-04-04
4184 Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes
Takahashi, H.; Miyaki, S.; Onouchi, H.; Motomura, T.; Idesako, N.; Takahashi, A.; Murase, M.; Fukuyoshi, S.; Endo, T.; Satou, K.; Naito, S.; Itoh, M.
10.1101/672840 — bioinformatics — Posted on 2020-04-04
4187 Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals
Mulholland, C. B.; Nishiyama, A.; Ryan, J.; Nakamura, R.; Yigit, M.; Glueck, I. M.; Trummer, C.; Qin, W.; Bartoschek, M. D.; Traube, F. R.; Parsa, E.; Ugur, E.; Modic, M.; Acharya, A.; Stolz, P.; Ziegenhain, C.; Wierer, M.; Enard, W.; Carell, T.; Lamb, D. C.; Takeda, H.; Nakanashi, M.; Bultmann, S.; Leonhardt, H.
10.1101/321604 — developmental biology — Posted on 2020-04-04
4190 Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue
Bayram, J.; Malcova, I.; Sinkovec, L.; Holubova, J.; Streparola, G.; Jurnecka, D.; Kucera, J.; Sedlacek, R.; Sebo, P.; Kamanova, J.
10.1101/2020.04.03.023549 — microbiology — Posted on 2020-04-03
4194 PhANNs, a fast and accurate tool and web server to classify phage structural proteins
Cantu Alessio Robles, V. A.; Salamon, P.; Seguritan, V.; Redfield, J.; Salamon, D.; Edwards, R.; Segall, A.
10.1101/2020.04.03.023523 — bioinformatics — Posted on 2020-04-03
4199 Phenological shifts drive biodiversity loss in plant--pollinator networks
Franco-Cisterna, M.; Ramos-Jiliberto, R.; Moisset de Espanes, P.; Vazquez, D. P.
10.1101/2020.04.03.023457 — ecology — Posted on 2020-04-03
4202 Direct RNA sequencing and early evolution of SARS-CoV-2
Taiaroa, G.; Rawlinson, D.; Featherstone, L.; Pitt, M.; Caly, L.; Druce, J.; Purcell, D.; Harty, L.; Tran, T.; Roberts, J.; Scott, N.; Catton, M.; Williamson, D.; Coin, L.; Duchene, S.
10.1101/2020.03.05.976167 — microbiology — Posted on 2020-04-03
4205 Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome
Wang, W.; Hu, D.; Feng, Y.; Wu, C.; Song, Y.; Li, A.; Liu, W.; Wang, Y.; Chen, K.; Tian, M.; Xiao, F.; Zhang, Q.; Chen, W.; Pan, P.; Wan, P.; Liu, Y.; Wu, K.; Wu, J.
10.1101/2020.04.03.023721 — immunology — Posted on 2020-04-03
4208 Core-periphery structure in mutualistic networks: an epitaph for nestedness?
Martin Gonzalez, A. M.; Vazquez, D. P.; Ramos-Jiliberto, R.; Lee, S. H.; Miele, V.
10.1101/2020.04.02.021691 — ecology — Posted on 2020-04-03
4209 Proteins and Ions Compete for Membrane Interaction: the case of Lactadherin
De Lio, A. M.; Paul, D.; Jain, R.; Morrissey, J. H.; Pogorelov, T. V.
10.1101/2020.04.03.023838 — biophysics — Posted on 2020-04-03
4211 Evaluating features of scientific conferences: A call for improvements
Sarabipour, S.; Schwessinger, B.; Mumoki, F. N.; Mwakilili, A. D.; Khan, A.; Debat, H. J.; Saez, P.; Seah, S.; Mestrovic, T.
10.1101/2020.04.02.022079 — scientific communication and education — Posted on 2020-04-03
4216 The Neuroanatomy of Speech Processing: A Large-Scale Lesion Study
Rogalsky, C.; Basilakos, A.; Rorden, C.; Pillay, S.; LaCroix, A. N.; Keator, L.; Mickelsen, S.; Anderson, S. W.; Love, T.; Fridriksson, J.; Binder, J.; Hickok, G.
10.1101/2020.04.02.022822 — neuroscience — Posted on 2020-04-03
4224 Metabolomic markers of colorectal tumor with different clinicopathological features
Long, Z.; Zhou, J.; Xie, K.; Wu, Z.; Yin, H.; Daria, V.; Tian, J.; Zhang, N.; Li, L.; Zhao, Y.; Wang, F.; wang, m.; Cui, Y.
10.1101/2020.04.02.021899 — cancer biology — Posted on 2020-04-03
4229 Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity
Ray, P.; Raghunathan, K.; Ahsan, A.; Allam, U. S.; Shukla, S.; Basrur, V.; Veatch, S.; Lawrence, T. S.; Nyati, M. K.; Ray, D.
10.1101/2020.04.02.022012 — cancer biology — Posted on 2020-04-03
4230 Alternative splicing is a developmental switch for hTERT expression
Penev, A.; Bazley, A.; Shen, M.; Boeke, J. D.; Savage, S. A.; Sfeir, A.
10.1101/2020.04.02.022087 — molecular biology — Posted on 2020-04-03
4234 An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.
Yao, Y.; Kadam, R. U.; Lee, C.-C. D.; Woehl, J. L.; Wu, N. C.; Zhu, X.; Kitamura, S.; Wilson, I. A.; Wolan, D. W.
10.1101/2020.04.02.022160 — biophysics — Posted on 2020-04-03
4237 Mechanical characteristics of ultrafast zebrafish larval swimming muscles
Mead, A. F.; Kennedy, G. G.; Palmer, B. M.; Ebert, A. M.; Warshaw, D. M.
10.1101/2020.04.02.010298 — physiology — Posted on 2020-04-03
4238 People can learn new walking patterns without walking
Song, C. N.; Stenum, J.; Leech, K. A.; Keller, C.; Roemmich, R. T.
10.1101/2020.04.02.021949 — neuroscience — Posted on 2020-04-03
4239 Inhibition of Pten activity promotes IB4 positive sensory neuronal axon growth
Zhou, L.-Y.; Han, F.; Qi, S.-B.; Ma, J.-J.; Ma, Y.-X.; Zhang, H.-C.; Xie, J.-L.; Fu, X.-Y.; Chen, J.-Q.; Li, B.; Yang, H.-L.; Zhou, F.; Saijilafu,
10.1101/2020.04.02.019042 — neuroscience — Posted on 2020-04-03
4240 Diffusion Basis Spectrum Imaging with Deep Neural Network Differentiates Distinct Histology in Pediatric Brain Tumors
Ye, Z.; Srinivasa, K.; Lin, J.; Viox, J.; Song, C.; Wu, A.; Sun, P.; Song, S.-K.; Dahiya, S.; Rubin, J. B.
10.1101/2020.04.02.020875 — neuroscience — Posted on 2020-04-03
4241 Three-dimensional mapping identifies distinct vascular niches for myelopoiesis
Zhang, J.; Wu, Q.; Johnson, C. B.; Olsson, A.; Slaughter, A.; May, M.; Weinhaus, B.; Dalessandro, A.; Engel, J. D.; Jiang, J. X.; Kofron, M.; Huang, L. F.; Salomonis, N.; Grimes, H. L.; Lucas, D.
10.1101/2020.04.02.014548 — immunology — Posted on 2020-04-03
4246 Prey choice of the common vampire bat on introduced species in an Atlantic forest land-bridge island
Goncalves, F.; Magioli, M.; Bovendorp, R. S.; Ferraz, K. M. P. M. d. B.; Bulascoschi, L. C.; Moreira, M. Z.; Galetti, M.
10.1101/2020.04.02.022236 — ecology — Posted on 2020-04-03
4247 Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum
Das, J.; Gomis, S.; Chen, J.; Yousefi, H.; Ahmed, S.; Mahmud, A.; Zhou, W.; Sargent, E.; Kelley, S.
10.1101/2020.04.02.020453 — bioengineering — Posted on 2020-04-03
4248 Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS)
Steyn, F. J.; Kirk, S. E.; Tefera, T. W.; Xie, T. Y.; Tracey, T. J.; Kelk, D.; Wimberger, E.; Garton, F. C.; Roberts, L.; Chapman, S. E.; Coombes, J. S.; Leevy, W. M.; Ferri, A.; Valle, C.; Rene, F.; Loeffler, J.-P.; McCombe, P. A.; Henderson, R. D.; Ngo, S. T.
10.1101/2020.04.02.021238 — neuroscience — Posted on 2020-04-03
4249 Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction
Cendon, C. c.; Du, W.; Durek, P.; Alexander, T.; Serene, L.; Lai, T.; Schulz, A. R.; Rao, A.; Heinz, G. A.; Stefanski, A.- L.; Bruns, A.; Siewert, K.; Doerner, T.; Chang, H.-D.; Volk, H. D.; Romagnani, C.; Mashreghi,, M.-F.; Thurley, K.; Radbruch, A.; Dong, J.
10.1101/2020.04.02.021709 — immunology — Posted on 2020-04-03
4250 Estrogen exacerbates mammary involution through neutrophil dependent and independent mechanism
Lin, V. C. L.; Lim, C. L.; Or, Y. Z.; Ong, Z.; Chung, H. H.; Shrestha, S.; Hayashi, H.; Chiba, S.; Lin, F.
10.1101/2020.04.03.023341 — developmental biology — Posted on 2020-04-03
4251 KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity
Lu, S.; Kim, H. S.; Cao, Y.; Bedi, K.; Chain, K.; Zhao, L.; Narayanan, I. V.; Yi, Z.; Yang, J.; Gu, Y.; Paulsen, M. T.; Ljungman, M.; Jeyarajan, S.; Thomas, D.; Dou, Y.; Crawford, H.; Pasca di Magliano, M.; Shi, J.
10.1101/2020.04.02.012138 — cancer biology — Posted on 2020-04-03
4253 In vivo selection for formate dehydrogenases with high efficiency and specificity towards NADP+
Calzadiaz Ramirez, L.; Calvo-Tusell, C.; Stoffel, G. M. M.; Lindner, S.; Osuna, S.; Erb, T. J.; Garcia-Borras, M.; Bar-Even, A.; Acevedo-Rocha, C. G.
10.1101/2020.04.02.022350 — biochemistry — Posted on 2020-04-03
4254 Dopaminergic signalling modulates reward-driven music memory consolidation
Ferreri, L.; Mas-Herrero, E.; Cardona, G.; Zatorre, R.; Antonijoan, R. M.; Valle, M.; Riba, J.; Ripolles, P.; Rodriguez-Fornells, A.
10.1101/2020.04.01.020305 — neuroscience — Posted on 2020-04-03
4255 Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy
O'Brien, E. S.; Fuglestad, B.; Lessen, H. J.; Stetz, M. A.; Lin, D. W.; Marques, B. S.; Gupta, K.; Fleming, K. G.; Wand, A. J.
10.1101/2020.04.02.022368 — biophysics — Posted on 2020-04-03
4258 Immunity to infections in arboviral vectors by integrated viral sequences: an evolutionary perspective
Crava, C.; Varghese, F. S.; Pischedda, E.; Halbach, R.; Palatini, U.; Marconcini, M.; Mattia, A.; Redmond, S. N.; Afrane, Y.; Ayala, D.; Paupy, C.; Carballar-Lejarazu, R.; Miesen, P.; van Rij, R. P.; Bonizzoni, M.
10.1101/2020.04.02.022509 — evolutionary biology — Posted on 2020-04-03
4259 Subcellular localization of the J-protein Sis1 regulates the heat shock response
Feder, Z. A.; Ali, A.; Singh, A.; Krakowiak, J.; Zheng, X.; Bindokas, V. P.; Wolfgeher, D.; Kron, S. J.; Pincus, D.
10.1101/2020.04.02.022491 — cell biology — Posted on 2020-04-03
4261 Identifying therapeutic drug targets for rare and common forms of short stature
Estrada, K.; Froelich, S.; Wuster, A.; Bauer, C. R.; Sterling, T.; Clark, W. T.; Ru, Y.; Trinidad, M.; Nguyen, H. P.; Luu, A. T.; Wendt, D.; Yogalingam, G.; Yu, G. K.; LeBowitz, J. L.; Cardon, L. R.
10.1101/2020.04.02.022624 — genetics — Posted on 2020-04-03
4264 Distributed coding of stimulus magnitude across the rodent prefrontal cortex
Henke, J.; Bunk, D.; von Werder, D.; Haeusler, S.; Flanagin, V. L.; Thurley, K.
10.1101/2020.04.02.021287 — neuroscience — Posted on 2020-04-03
4265 Auditory beat perception is related to speech output fluency in post-stroke aphasia
Stefaniak, J. D.; Lambon Ralph, M. A.; De Dios Perez, B.; Griffiths, T. D.; Grube, M.
10.1101/2020.04.02.022475 — neuroscience — Posted on 2020-04-03
4266 Disinhibition of the orbitofrontal cortex biases goal-directed behaviour in obesity
Naef, L.; Seabrook, L. T.; Baimel, C.; Judge, A. K.; Kenney, T.; Ellis, M.; Qiao, M.; Floresco, S. B.; Borgland, S. L.
10.1101/2020.04.02.022681 — neuroscience — Posted on 2020-04-03
4269 Epigenomic Diversity of Cortical Projection Neurons in the Mouse Brain
Zhang, Z.; Zhou, J.; Tan, P.; Pang, Y.; Rivkin, A.; Kirchgessner, M. A.; Williams, E.; Lee, C.-T.; Liu, H.; Franklin, A. D.; Miyazaki, P. A.; Bartlett, A.; Aldridge, A.; Vu, M.; Boggeman, L.; Fitzpatrick, C.; Nery, J.; Castanon, R. G.; Rashid, M.; Jacobs, M.; Ito, T.; Dominguez, B.; Niu, S.-Y.; Smith, J. B.; O'Connor, C.; Lee, K.-F.; Jin, X.; Mukamel, E. A.; Behrens, M. M.; Ecker, J. R.; Callaway, E. M.
10.1101/2020.04.01.019612 — neuroscience — Posted on 2020-04-03
4272 A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity
Geisler, C. E.; Ghimire, S.; Bruggink, S. M.; Miller, K. E.; Weninger, S. N.; Kronenfeld, J. M.; Yoshino, J.; Klein, S.; Duca, F. A.; Renquist, B. J.
10.1101/2020.04.02.022699 — physiology — Posted on 2020-04-03
4275 Chromatin dynamics during hematopoiesis reveal discrete regulatory modules instructing differentiation
Georgolopoulos, G.; Iwata, M.; Psatha, N.; Nishida, A.; Som, T.; Yiangou, M.; Stamatoyannopoulos, J. A.; Vierstra, J.
10.1101/2020.04.02.022566 — developmental biology — Posted on 2020-04-03
4276 The scar constituent Collagen I triggers coordinated collective migration and invasion in a 3D spheroid model of early endometriotic lesions
Stejskalova, A.; Fincke, V.; Nowak, M.; Schmidt, Y.; von Wahlde, M.-K.; Schäfer, S. D.; Kiesel, L.; Greve, B.; Götte, M.
10.1101/2020.04.02.005322 — bioengineering — Posted on 2020-04-03
4277 A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL
Tong, B.; Spradlin, J. N.; Novaes, L. F. T.; Zhang, E.; Hu, X.; Moeller, M.; Brittain, S. M.; McGregor, L. M.; McKenna, J. M.; Tallarico, J. A.; Schirle, M.; Maimone, T. J.; Nomura, D. K.
10.1101/2020.04.02.022541 — biochemistry — Posted on 2020-04-03
4279 The Arabidopsis NOT4A E3 ligase coordinates PGR3 expression to regulate chloroplast protein translation
Bailey, M.; Ivanauskaite, A.; Grimmer, J.; Akintewe, O.; Payne, A. C.; Etherington, R. D.; Labandera, A.-M.; Osborne, R.; Rantala, M.; Baginsky, S.; Mulo, P.; Gibbs, D. J.
10.1101/2020.04.02.021998 — plant biology — Posted on 2020-04-03
4285 Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing
Chambers, E. S.; Vukmanovic-Stejic, M.; Shih, B. B.; Trahir, H.; Subramanian, P.; Devine, O. P.; Glanville, J.; Gilroy, D.; Rustin, M.; Freeman, T. C.; Mabbott, N. A.; Akbar, A. N.
10.1101/2020.04.02.020081 — immunology — Posted on 2020-04-03
4287 CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries
Braun, C. J.; Jeremias, I. J.; Becker, M.; Noll-Puchta, H.; Amend, D.; Nolte, F.; Fuchs, C.
10.1101/2020.04.02.021279 — genomics — Posted on 2020-04-03
4291 KnetMiner - Intelligent search and visualisation of connected data to explain complex traits and diseases
Hassani-Pak, K.; Singh, A.; Brandizi, M.; Hearnshaw, J.; Phillips, A. L.; Doonan, J. H.; Rawlings, C.
10.1101/2020.04.02.017004 — bioinformatics — Posted on 2020-04-03
4294 Expansion of frozen hybrids in guppy ectoparasite, Gyrodactylus turnbulli
Konczal, M.; Przesmycka, K.; Mohammed, R. S.; Hahn, C.; Cable, J.; Radwan, J.
10.1101/2020.04.02.021329 — evolutionary biology — Posted on 2020-04-03
4296 Nuclear Lamins A/C and B1 Provide a Structural Framework That Organizes and Anchors Nuclear Pore Complexes
Kittisopikul, M.; Shimi, T.; Tatli, M.; Tran, J. R.; Zheng, Y.; Medalia, O.; Jaqaman, K.; Adam, S. A.; Goldman, R. D.
10.1101/2020.04.03.022798 — cell biology — Posted on 2020-04-03
4297 Recursive Convolutional Neural Networks for Epigenomics
Symeonidi, A.; Nikolaou, A.; Johannes, F.; Christlein, V.
10.1101/2020.04.02.021519 — bioinformatics — Posted on 2020-04-03
4298 AutoOmics: An AutoML Tool for Multi-Omics Research
Xu, C.; Liu, D.; Zhang, L.; Xu, Z.; He, W.; Zheng, M.; Qiao, N.
10.1101/2020.04.02.021345 — bioinformatics — Posted on 2020-04-03
4300 Multiple freeze-thaw cycles lead to a loss of consistency in poly(A)-enriched RNA sequencing
Kellman, B. P.; Baghdassarian, H. M.; Pramparo, T.; Shamie, I.; Gazestani, V. H.; Begzati, A.; Li, S.; Nalabolu, S.; Murray, S.; Lopez, L.; Pierce, K.; Courchesne, E.; Lewis, N. E.
10.1101/2020.04.01.020792 — bioinformatics — Posted on 2020-04-03
4302 Recovery of cryo-injured rabbit urethras by biofabricated C-shaped adipose-derived mesenchymal cell structures
Gautam Silwal, S.; Imamura, T.; Shimamura, M.; Minagawa, T.; Nakazawa, M.; Ogawa, T.; Ishizuka, O.
10.1101/2020.04.02.022715 — bioengineering — Posted on 2020-04-03
4303 Mercury methylation trait dispersed across diverse anaerobic microbial guilds in a eutrophic sulfate-enriched lake
Peterson, B. D.; McDaniel, E. A.; Schmidt, A. G.; Lepak, R. F.; Tran, P. Q.; Marick, R. A.; Ogorek, J. M.; DeWild, J. F.; Krabbenhoft, D. P.; McMahon, K. D.
10.1101/2020.04.01.018762 — genomics — Posted on 2020-04-03
4304 Lessons from the analysis of TAD boundary deletions in normal population
Smol, T.; Sige, J.; Thuillier, C.; Frenois, F.; Brunelle, P.; Rama, M.; ROCHE, C.; Manouvrier, S.; Petit, F.; GHOUMID, J.
10.1101/2020.04.01.021188 — genomics — Posted on 2020-04-03
4305 Ancient human genomes reveal a hidden history of strong selection in Eurasia
Souilmi, Y.; Tobler, R.; Johar, A.; Williams, M.; Grey, S. T.; Schmidt, J.; Teixeira, J. C.; Rohrlach, A.; Tuke, J.; Johnson, O. L.; Gower, G. R.; Turney, C.; Cox, M.; Huber, C. D.; Cooper, A.
10.1101/2020.04.01.021006 — genomics — Posted on 2020-04-03
4308 Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells
Kumar, R. J.; Chao, H. X.; Roberts, V. R.; Sullivan, A. R.; Shah, S. J.; Simpson, D. A.; Feng, W.; Wozny, A.-S.; Kumar, S.; Purvis, J. E.; Gupta, G. P.
10.1101/2020.04.01.021253 — cell biology — Posted on 2020-04-03
4310 Pro-metastatic gene expression, immune evasion and an altered HPV spectrum characterize an aggressive subtype of cervical cancer
Chakravarthy, A.; Henderson, S.; Dong, C.; Kirkwood, N.; Jeyakumar, M.; McDermott, J.; Su, X.; Egawa, N.; Fjeldbo, C. S.; Halle, M. K.; Krakstad, C.; Soleiman, A.; Sprung, S.; Lyng, H.; Fiegl, H.; Salvesen, H.; Doorbar, J.; Chester, K.; Feber, A.; Fenton, T. R.
10.1101/2020.04.02.019711 — cancer biology — Posted on 2020-04-03
4311 Succinct Dynamic de Bruijn Graphs
Alipanahi, B.; Kuhnle, A.; Puglisi, S.; Salmela, L.; Boucher, C.
10.1101/2020.04.01.018481 — bioinformatics — Posted on 2020-04-03
4314 New Viral Biogeochemical Roles Revealed Through Metagenomic Analysis of Lake Baikal
Hernandes Coutinho, F.; Cabello-Yeves, P. J.; Gonzalez-Serrano, R.; Rosselli, R.; Lopez-Perez, M.; Zemskaya, T.; Zakharenko, A.; Ivanov, V.; Rodriguez-Valera, F.
10.1101/2020.04.02.019802 — microbiology — Posted on 2020-04-03
4315 Capsicumine: a new peptide from red peppers turns out to be a powerful antibiofilm agent and displays a new mechanism of action, matrix anti-assembly
GOMES VON BOROWSKI, R.; CHAT, S.; SCHNEIDER, R.; GIUDICE, E.; RIGON ZIMMER, A.; Baggio Gnoatto, S. C.; MACEDO, A. J.; GILLET, R.
10.1101/2020.04.03.022020 — microbiology — Posted on 2020-04-03
4317 The Parkinson's Disease GWAS Locus Browser
Grenn, F. P.; Kim, J. J.; Makarious, M. B.; Iwaki, H.; Illarionova, A.; Brolin, K.; Kluss, J. H.; Schumacher-Schuh, A. F.; Leonard, H.; Faghri, F.; Billingsley, K. J.; Krohn, L. M.; Hall, A.; Diez-Fairen, M.; Perinan, M. T.; Sandor, C.; Webber, C.; Gibbs, J. R.; Nalls, M. A.; Singleton, A. B.; Bandres-Ciga, S.; Reed, X.; Blauwendraat, C.; International Parkinson's Disease Genomics Consortium,
10.1101/2020.04.01.020404 — genetics — Posted on 2020-04-03
4320 modleR: a modular workflow to perform ecological niche modeling in R
Sanchez-Tapia, A.; Mortara, S. R.; Rocha, D. S. B.; Barros, F. S. M.; Gall, G. M.; Siqueira, M. F. d.
10.1101/2020.04.01.021105 — ecology — Posted on 2020-04-03
4321 Computational target fishing by mining transcriptional data using a novel Siamese spectral-based graph convolutional network
Zhong, F.; Wu, X.; Li, X.; Wan, D.; Fu, Z.; Liu, X.; Wan, X.; Yang, T.; Luo, X.; Chen, K.; Jiang, H.; Zheng, M.
10.1101/2020.04.01.019166 — bioinformatics — Posted on 2020-04-03
4323 Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung.
Llamazares Prada, M.; Espinet, E.; Mijosek, V.; Schwartz, U.; Waszak, S. M.; Lutsik, P.; Tamas, R.; Richter, M.; Behrendt, A.; Pohl, S.; Benz, N.; Muley, T.; Warth, A.; Heussel, C. P.; Winter, H.; Herth, F.; Mertens, T.; Karmouty-Quintana, H.; Koch, I.; Benes, V.; Korbel, J. O.; Trumpp, A.; Wyatt, D.; Stahl, H.; Plass, C.; Jurkowska, R. Z.
10.1101/2020.04.01.018861 — cell biology — Posted on 2020-04-03
4324 Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6
Gao, Y.; Eskici, G.; Ramachandran, S.; Poitevin, F.; Seven, A. B.; Panova, O.; Skiniotis, G.; Cerione, R. A.
10.1101/2020.04.01.020651 — biophysics — Posted on 2020-04-03
4325 Integrative Network Fusion: a multi-omics approach in molecular profiling
Chierici, M.; Bussola, N.; Marcolini, A.; Francescatto, M.; Zandona, A.; Trastulla, L.; Agostinelli, C.; Jurman, G.; Furlanello, C.
10.1101/2020.04.01.020685 — bioinformatics — Posted on 2020-04-03
4328 SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation
Zhang, Q.; Zhang, H.; Huang, K.; Yang, Y.; Hui, X.; Gao, J.; He, X.; Li, C.; Gong, W.; Zhang, Y.; Peng, C.; Gao, X.; Chen, H.; Zou, Z.; Shi, Z.; Jin, M.
10.1101/2020.04.01.021196 — microbiology — Posted on 2020-04-03
4329 Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing
Pouikli, A.; Parekh, S.; Maleszewska, M.; Baghdadi, M.; Tripodi, I.; Nikopoulou, C.; Folz-Donahue, K.; Hinze, Y.; Mesaros, A.; Giavalisco, P.; Dowell, R.; Partridge, L.; Tessarz, P.
10.1101/2020.04.02.022293 — cell biology — Posted on 2020-04-03
4331 Conserved and Divergent Modulation of Calcification in Atherosclerosis and Aortic Valve Disease by Tissue Extracellular Vesicles
Blaser, M. C.; Buffolo, F.; Halu, A.; Schlotter, F.; Higashi, H.; Pantano, L.; Saddic, L. A.; Atkins, S. K.; Rogers, M. A.; Pham, T.; Shvartz, E.; Sukhova, G. K.; Monticone, S.; Camussi, G.; Body, S. C.; Muehlschlegel, J. D.; Singh, S. A.; Aikawa, M.; Aikawa, E.
10.1101/2020.04.02.022525 — systems biology — Posted on 2020-04-03
4332 RANDOMIZE: A Web Server for Data Randomization
Wani, A. H.; Armstrong, D.; Dahrendorff, J.; Uddin, M.
10.1101/2020.04.02.013656 — bioinformatics — Posted on 2020-04-03
4336 Single-cell Transcriptomics Identify Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons
De Micheli, A. J.; Swanson, J. B.; Disser, N. P.; Martinez, L. M.; Walker, N. R.; Oliver, D. J.; Cosgrove, B. D.; Mendias, C. L.
10.1101/801266 — cell biology — Posted on 2020-04-02
4337 Dense cellular segmentation for EM using 2D-3D neural network ensembles
Guay, M. D.; Emam, Z. A. S.; Anderson, A. B.; Aronova, M. A.; Leapman, R. D.
10.1101/2020.01.05.895003 — cell biology — Posted on 2020-04-02
4345 Effectiveness of active learning for ecology teaching: the perspective of students vs their grades
Sperber, C. F.; Szinwelski, N.; Ferreira, F. F.; Paiva, L. F.; Prasniewski, V. M.; Teixeira, A. F. d. P.; Costa, B. C.; Campos, R. B. F.; Vaz de Mello, R. M. A.; Wiggins, B.
10.1101/2020.04.02.021584 — ecology — Posted on 2020-04-02
4349 Exploring the understudied human kinome for research and therapeutic opportunities
The NIH Understudied Kinome Consortium, ; Moret, N.; Liu, C.; Gyori, B. M.; Bachman, J. A.; Steppi, A.; Taujale, R.; Huang, L.-C.; Hug, C.; Berginski, M.; Gomez, S. M.; Kannan, N.; Sorger, P.
10.1101/2020.04.02.022277 — systems biology — Posted on 2020-04-02
4350 Visual mate preference evolution during butterfly speciation is linked to neural processing genes
Rossi, M.; Hausmann, A. E.; Thurman, T. J.; Montgomery, S. H.; Papa, R.; Jiggins, C. D.; Mcmillan, W. O.; Merrill, R. M.
10.1101/2020.03.22.002121 — evolutionary biology — Posted on 2020-04-02
4351 rapidPop: Rapid population assessments of wildlife using camera trap data in R Shiny Applications
Tabak, M. A.; Lewis, J. S.; Schlichting, P. E.; Snow, N. P.; VerCauteren, K. C.; Miller, R. S.
10.1101/2020.03.30.017103 — ecology — Posted on 2020-04-02
4352 Osh6 requires Ist2 for localization to the ER-PM contacts and efficient phosphatidylserine transport
D'Ambrosio, J. M.; Albanese, V.; Lipp, N.-F.; FLEURIOT, L.; Debayle, D.; Drin, G.; Copic, A.
10.1101/2020.01.31.928440 — cell biology — Posted on 2020-04-02
4353 Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes
Takahashi, H.; Miyaki, S.; Onouchi, H.; Motomura, T.; Idesako, N.; Takahashi, A.; Murase, M.; Fukuyoshi, S.; Endo, T.; Satou, K.; Naito, S.; Itoh, M.
10.1101/672840 — bioinformatics — Posted on 2020-04-02
4354 Structural analysis of SARS-CoV-2 and prediction of the human interactome
Vandelli, A.; Monti, M.; Milanetti, E.; Delli Ponti, R.; Tartaglia, G. G.
10.1101/2020.03.28.013789 — bioinformatics — Posted on 2020-04-02
4356 In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia
Farrell, J. S.; Colangeli, R.; Dudok, B.; Wolff, M. D.; Nguyen, S. L.; Dickson, C. T.; Soltesz, I.; Teskey, G. C.
10.1101/2020.01.30.926717 — neuroscience — Posted on 2020-04-02
4357 Anticipatory responses along motion trajectories in awake monkey area V1
Benvenuti, G.; Chemla, S.; Boonman, A.; Perrinet, L.; Masson, G. S.; Chavane, F.
10.1101/2020.03.26.010017 — neuroscience — Posted on 2020-04-02
4358 Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia
Ramanan, S.; Roquet, D.; Goldberg, Z.-l.; Hodges, J. R.; Piguet, O.; Irish, M.; Lambon Ralph, M. A.
10.1101/767269 — neuroscience — Posted on 2020-04-02
4362 Genome-wide dysregulation of histone acetylation in the Parkinsons disease brain
Toker, L.; Tran, G. T.; Sundaresan, J.; Tysnes, O.-B.; Alves, G.; Haugarvoll, K.; Nido, G. S.; Dolle, C.; Tzoulis, C.
10.1101/785550 — genomics — Posted on 2020-04-02
4363 Splicing conservation signals in plant long non-coding RNAs
Corona-Gomez, J. A.; Garcia-Lopez, I. J.; Stadler, P. F.; Fernandez-Valverde, S. L.
10.1101/588954 — genomics — Posted on 2020-04-02
4364 Functionally-informed fine-mapping and polygenic localization of complex trait heritability
Weissbrod, O.; Hormozdiari, F.; Benner, C.; Cui, R.; Ulirsch, J.; Gazal, S.; Schoech, A. P.; van de Geijn, B.; Reshef, Y.; Marquez-Luna, C.; O'Connor, L. J.; Pirinen, M.; Finucane, H. K.; Price, A. L.
10.1101/807792 — genetics — Posted on 2020-04-02
4367 Global Landscape of Native Protein Complexes in Synechocystis sp. PCC 6803
Xu, C.; Wang, B.; Yang, L.; Hu, L. Z.; Yi, L.; Wang, Y.; Chen, S.; Emili, A.; Wan, C.
10.1101/2020.03.07.980128 — biochemistry — Posted on 2020-04-02
4369 Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
Pinto-Fernandez, A.; Salio, M.; Partridge, T.; Chen, J.; Vere, G.; Greenwood, H.; Olie, C. S.; Damianou, A.; Scott, H. C.; Diaz-Saez, L.; Smith, P.; Gonzalez-Lopez, C.; Huber, K.; Muschel, R.; Borrow, P.; Cerundolo, V.; Kessler, B. M.
10.1101/2020.03.31.005629 — cancer biology — Posted on 2020-04-02
4370 Chromosome organization by one-sided and two-sided loop extrusion
Banigan, E. J.; van den Berg, A. A.; Brandao, H. B.; Marko, J. F.; Mirny, L. A.
10.1101/815340 — biophysics — Posted on 2020-04-02
4372 Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release
Geisler, C. E.; Ghimire, S.; Hepler, C.; Miller, K. E.; Higgins, M. R.; Yoshino, J.; Klein, S.; Renquist, B. J.
10.1101/475608 — physiology — Posted on 2020-04-02
4373 Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice
Botezelli, J. D.; Overby, P.; Lindo, L.; Wang, S. D.; Haida, O.; Lim, G. E.; Templeman, N. M.; Pauli, J. R.; Johnson, J. D.
10.1101/2020.03.31.018432 — physiology — Posted on 2020-04-02
4376 Distinctive airway microbial ecology of smokers and asthmatics
Turek, E. M.; Cox, M. J.; Hunter, M.; Hui, J.; James, P.; Willis-Owen, S. A.; Cuthbertson, L.; James, A.; Musk, A. W.; Moffatt, M. F.; Cookson, W. O.
10.1101/583559 — microbiology — Posted on 2020-04-02
4378 HUMAN PANCREATIC CANCER CELLS UNDERGO PROFOUND METABOLIC REPROGRAMMING TOWARDS CELLULAR STEMNESS AS ADAPTATION TO INHIBITION OF THE AKT PATHWAY
Arasanz, H.; Hernandez, C.; Bocanegra, A.; Chocarro, L.; Zuazo, M.; Gato, M.; Ausin, K.; Santamaria, E.; Fernandez, J.; Fernandez, G.; Monasterio, E.; Rodriguez, C.; Blanco, I.; Vera, R.; Escors, D.; Kochan, G.
10.1101/2020.04.01.020446 — cancer biology — Posted on 2020-04-02
4382 VISTA: Virtual ImmunoSTAining for pancreatic disease quantification in murine cohorts
Ternes, L.; Huang, G.; Lanciault, C.; Thibault, G.; Riggers, R.; Gray, J. W.; Muschler, J.; Chang, Y. H.
10.1101/2020.04.01.020842 — bioinformatics — Posted on 2020-04-02
4388 The role of thickness inhomogeneities in hierarchical cortical folding
da Costa Campos, L.; Hornung, R.; Gompper, G.; Elgeti, J.; Caspers, S.
10.1101/2020.04.01.020172 — neuroscience — Posted on 2020-04-02
4389 Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons
Berg, J.; Sorensen, S. A.; Ting, J. T.; Miller, J. A.; Chartrand, T.; Buchin, A.; Bakken, T. E.; Budzillo, A.; Dee, N.; Ding, S.-L.; Gouwens, N. W.; Hodge, R. D.; Kalmbach, B.; Lee, C.; Lee, B. R.; Alfiler, L.; Baker, K.; Barkan, E.; Beller, A.; Berry, K.; Bertagnolli, D.; Bickley, K.; Bomben, J.; Braun, T.; Brouner, K.; Casper, T.; Chong, P.; Crichton, K.; Dalley, R.; de Frates, R.; Desta, T.; Dingman Lee, S.; D'Orazi, F.; Dotson, N.; Egdorf, T.; Enstrom, R.; Farrell, C.; Feng, D.; Fong, O.; Furdan, S.; Galakhova, A. A.; Gamlin, C.; Gary, A.; Glandon, A.; Goldy, J.; Gorham, M.; Goriounova, N.
10.1101/2020.03.31.018820 — neuroscience — Posted on 2020-04-02
4394 Adolescent rats show estrous cycle-mediated sex differences in extinction of conditioned fear
Perry, C. J.; Ganella, D. E.; Nguyen, L. D.; Du, X.; Drummond, K. D.; Whittle, S.; Pang, T. Y.; Kim, J. H.
10.1101/2020.03.31.019273 — animal behavior and cognition — Posted on 2020-04-02
4395 Ventral arkypallidal neurons modulate accumbal firing to promote reward consumption.
Vachez, Y. M.; Tooley, J. R.; Casey, E.; Earnest, T.; Abiraman, K.; Silberberg, H.; Godynyuk, E.; Uddin, O.; Marconi, L. J.; Le Pichon, C.; Creed, M. C.
10.1101/2020.04.01.020099 — neuroscience — Posted on 2020-04-02
4397 Inferring the infant pain experience: a translational fMRI-based signature approach
Duff, E. P.; Moultrie, F.; Goksan, S.; van der Vaart, M.; Abos, A.; Baxter, L.; Fitzgibbon, S. P.; Wager, T. D.; Slater, R.
10.1101/2020.04.01.998864 — neuroscience — Posted on 2020-04-02
4399 Risperidone-induced changes in DNA methylation from peripheral blood in first-episode schizophrenia parallel neuroimaging and cognitive phenotype
Hu, M.; Xia, Y.; Zong, X.; Sweeney, J. A.; Bishop, J. R.; Giase, G.; Li, B.; Rubin, L. H.; Chen, X.; Wang, Y.; Kunney, L.; Li, Z.; He, Y.; Liu, C.; Chen, C.; Chen, X.; Tang, J.
10.1101/2020.03.31.018283 — pharmacology and toxicology — Posted on 2020-04-02
4405 Flotillin mediated membrane fluidity controls peptidoglycan synthesis and MreB movement.
Zielinska, A.; Savietto, A.; de Sousa Borges, A.; Martinez, D.; Berbon, M.; Roelofsen, J. R.; Hartman, A. M.; de Boer, R.; van der Klei, I. J.; Hirsch, A. K. H.; Habenstein, B.; Bramkamp, M.; Scheffers, D.-J.
10.1101/736819 — microbiology — Posted on 2020-04-02
4408 GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor
Guida, C.; Miranda, C.; Wernstedt Asterholm, I.; Basco, D.; Benrick, A.; Chanclon, B.; Chibalina, M.; Harris, M.; Kellard, J.; McCulloch, L.; Real, J.; Rorsman, N.; Yeung, H. Y.; Reimann, F.; Shigeto, M.; Clark, A.; Thorens, B.; Rorsman, P.; Ladds, G.; Ramracheya, R.
10.1101/785667 — molecular biology — Posted on 2020-04-02
4409 An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossing.
Benmimoun, B.; Papastefanaki, F.; Perichon, B.; Segklia, K.; Roby, N.; Miriagou, V.; Schmitt, C.; Matsas, R.; Dramsi, S.; Speder, P.
10.1101/2020.02.28.970376 — microbiology — Posted on 2020-04-02
4411 Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Liang, Q.; Li, J.; Guo, M.; Tian, X.; Liu, C.; Wang, X.; Yang, X.; Wu, P.; Xiao, Z.; Qu, Y.; Yin, Y.; Fu, J.; Zhu, Z.; Liu, Z.; Peng, C.; Zhu, T.
10.1101/2020.03.31.019216 — microbiology — Posted on 2020-04-02
4412 Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia
Pizzorno, A.; Padey, B.; Julien, T.; Trouillet-Assant, S.; Traversier, A.; Errazuriz-Cerda, E.; Fouret, J.; Dubois, J.; Gaymard, A.; Lescure, X.; Duliere, V.; Brun, P.; Constant, S.; Poissy, J.; Lina, B.; Yazdanpanah, Y.; Terrier, O.; Rosa-Calatrava, M.
10.1101/2020.03.31.017889 — microbiology — Posted on 2020-04-02
4413 Identification of a common deletion in the spike protein of SARS-CoV-2
Liu, Z.; Zheng, H.; Yuan, R.; Li, M.; Lin, H.; Peng, J.; Xiong, Q.; Sun, J.; Li, B.; Wu, J.; Ke, C.; Hulswit, R. J. G.; Bowden, T. A.; Rambaut, A.; Pybus, O. G.; Loman, N.; Lu, J.
10.1101/2020.03.31.015941 — genetics — Posted on 2020-04-02
4420 Genome-wide bisulfite sequencing data of normal and Ascosphaera apis-infected larval guts of eastern honeybee
Du, Y.; Zhu, Z.; Chen, H.; Fan, Y.; Wang, J.; Fan, X.; Jiang, H.; Xiong, C.; Zheng, Y.; Chen, D.; Guo, R.
10.1101/2020.04.01.020040 — molecular biology — Posted on 2020-04-02
4421 Cellular senescence and quiescence are associated with altered ribosomal RNA methylation and processing
Yang, G.; Heisenberger, C.; Kos-Braun, I. C.; Polacek, N.; Grillari, J.; Schosserer, M.; Kos, M.
10.1101/2020.04.01.019653 — molecular biology — Posted on 2020-04-02
4422 Cell-type specialization in the brain is encoded by specific long-range chromatin topologies
Winick-Ng, W.; Kukalev, A.; Harabula, I.; Zea Redondo, L.; Meijer, M.; Serebreni, L.; Bianco, S.; Szabo, D.; Chiariello, A. M.; Irastorza Azcarate, I.; Fiorillo, L.; Musella, F.; Thieme, C.; Irani, E.; Torlai Triglia, E.; Kolodziejczyk, A. A.; Abentung, A.; Apostolova, G.; Paul, E. J.; Franke, V.; Kempfer, R.; Akalin, A.; Teichmann, S.; Dechant, G.; Ungless, M. A.; Nicodemi, M.; Castelo-Branco, G.; Pombo, A.
10.1101/2020.04.02.020990 — molecular biology — Posted on 2020-04-02
4423 Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus
Cross, R. W.; Bornholdt, Z. A.; Prasad, A. N.; Geisbert, J. B.; Borisevich, V.; Agans, K. N.; Deer, D. J.; Melody, K.; Fenton, K. A.; Feldmann, H.; Sprecher, A.; Geisbert, T. W.
10.1101/2020.04.01.018275 — microbiology — Posted on 2020-04-02
4426 Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes
Niu, L.; Shen, W.; Shi, Z.; He, N.; Wan, J.; Sun, J.; Zhang, Y.; Huang, Y.; Wang, W.; Fang, C.; Li, J.; Zheng, P.; Cheung, E.; Chen, Y.; Li, L.; Hou, C.
10.1101/2020.04.02.021378 — genetics — Posted on 2020-04-02
4428 A high-throughput platform for feedback-controlled directed evolution.
DeBenedictis, E. A.; Chory, E. J.; Gretton, D.; Wang, B.; Esvelt, K.
10.1101/2020.04.01.021022 — bioengineering — Posted on 2020-04-02
4429 Glycan analysis of human neutrophil granules implicates a maturation-dependent glycosylation machinery
Venkatakrishnan, V.; Dieckmann, R.; Loke, I.; Tjondro, H.; Chatterjee, S.; Bylund, J.; Thaysen-Andersen, M.; Karlsson, N. G.; Karlsson-Bengtsson, A.
10.1101/2020.04.02.021394 — biochemistry — Posted on 2020-04-02
4431 Automatic identification of small molecules that promote cell conversion and reprogramming
Napolitano, F.; Rapakoulia, T.; Annunziata, P.; Hasegawa, A.; Cardon, M.; Napolitano, S.; Vaccaro, L.; Iuliano, A.; Wanderlingh, L. G.; Kasukawa, T.; Medina, D. L.; Cacchiarelli, D.; Gao, X.; di Bernardo, D.; Arner, E.
10.1101/2020.04.01.021089 — bioinformatics — Posted on 2020-04-02
4432 Geometric differences between nuclear envelopes of Wild-type and Chlamydia trachomatis-infected HeLa cells
Karabag, C.; Jones, M. L.; Peddie, C. J.; Weston, A. E.; Collinson, L. M.; Reyes-Aldasoro, C. C.
10.1101/2020.04.02.021733 — cell biology — Posted on 2020-04-02
4433 Fast protein database as a service with kAAmer
Deraspe, M.; Boisvert, S.; Laviolette, F.; Roy, P. H.; Corbeil, J.
10.1101/2020.04.01.019984 — bioinformatics — Posted on 2020-04-02
4435 Coding de novo mutations identified by WGS reveal novel orofacial cleft genes
Bishop, M.; Diaz Perez, K.; Sun, M.; Ho, S.; Chopra, P.; Mukhopadhyay, N.; Hetmanski, J.; Taub, M.; Moreno-Uribe, L.; Valencia-Ramirez, L. C.; Restrepo Muneton, C.; Wehby, G.; Hecht, J.; Deleyiannis, F.; Weinberg, S.; Wu-Chou, Y. H.; Chen, P.; Brand, H.; Epstein, M.; Ruczinski, I.; Murray, J.; Beaty, T.; Feingold, E.; Lipinski, R.; Cutler, D.; Marazita, M.; Leslie, E.
10.1101/2020.04.01.019927 — genetics — Posted on 2020-04-02
4436 NOGEA: Network-Oriented Gene Entropy Approach for Dissecting Disease Comorbidity and Drug Repositioning
Guo, Z.; Fu, Y.; Huang, C.; Zheng, C.; Wu, Z.; Chen, X.; Gao, S.; Ma, Y.; Shahen, M.; Tu, P.; Zhu, J.; Wang, Z.; Xiao, W.; Wang, Y.
10.1101/2020.04.01.019901 — systems biology — Posted on 2020-04-02
4440 Functional diversification of Ser-Arg rich protein kinases to control ubiquitin-dependent neurodevelopmental signalling
Bustos, F.; Segarra-Fas, A.; Nardocci, G.; Cassidy, A.; Antico, O.; Brandenburg, L.; Macartney, T.; Toth, R.; Hastie, C. J.; Gourlay, R.; Vargese, J.; Soares, R.; Montecino, M.; Findlay, G. M.
10.1101/2020.04.02.005041 — developmental biology — Posted on 2020-04-02
4441 Intergenerational pathogen-induced diapause in C. elegans is modulated by mir-243.
Gabaldon, C.; Legüe, M.; Palominos, M. F.; Verdugo, L.; Gutzwiller, F.; Calixto, A.
10.1101/2020.03.31.019349 — microbiology — Posted on 2020-04-02
4445 Resources for genome editing in livestock: Cas9-expressing chickens and pigs
Bartsch, D.; Sid, H.; Rieblinger, B.; Hellmich, R.; Schlickenrieder, A.; Lengyel, K.; Flisikowski, K.; Flisikowska, T.; Simm, N.; Grodziecki, A.; Perleberg, C.; Kuppat, C.; Wolf, E.; Kessler, B.; Kettler, L.; Luksch, H.; Hagag, I. T.; Wise, D.; Kaufman, J.; Kaufer, B. B.; Schnieke, A.; Schusser, B.
10.1101/2020.04.01.019679 — molecular biology — Posted on 2020-04-02
4446 Ecology and molecular targets of hypermutation in the global microbiome.
Roux, S.; Paul, B. G.; Bagby, S. C.; Allen, M. A.; Attwood, G.; Cavicchioli, R.; Chistoserdova, L.; Hallam, S.; Hernandez, M. E.; Hess, M.; Liu, W.-T.; O'Malley, M. A.; Peng, X.; Rich, V. I.; Saleska, S.; Eloe-Fadrosh, E. A.
10.1101/2020.04.01.020958 — microbiology — Posted on 2020-04-02
4447 Common maternal and fetal genetic variants show expected polygenic effects on the probability of being born small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies
Beaumont, R. N.; Kotecha, S. J.; Wood, A. R.; Knight, B. A.; Sebert, S.; McCarthy, M. I.; Hattersley, A. T.; Jarvelin, M.-R.; Timpson, N. J.; Freathy, R. M.; Kotecha, S.
10.1101/2020.03.25.005660 — genetics — Posted on 2020-04-02
4448 Risk of somatic mitochondrial deletions is affected by the secondary structure of the mitochondrial genome
Mikhailova, A. A.; Shamansky, V.; Ushakova, K.; Mikhaylova, A. G.; Oreshkov, S.; Knorre, D.; Tretiakov, E. O.; Zazhytska, M.; Kunz, W.; Reymond, A.; Mazunin, I.; Bazykin, G. A.; Gunbin, K.; Fellay, J.; Tanaka, M.; Khrapko, K.; Popadin, K.
10.1101/603282 — genetics — Posted on 2020-04-02
4449 Episignatures stratifying ADNP syndrome show modest correlation with phenotype
Breen, M. S.; Garg, P.; Tang, L.; Mendonca, D.; Levy, T.; Barbosa, M.; Arnett, A. B.; Kurtz-Nelson, E.; Agolini, E.; Battaglia, A.; Chiocchetti, A. G.; Freitag, C. M.; Garcia-Alcon, A.; Grammatico, P.; Hertz-Picciotto, I.; Ludena-Rodriguez, Y.; Moreno, C.; Novelli, A.; Parellada, M.; Pascolini, G.; Tassone, F.; Grice, D. E.; Bernier, R. A.; Kolevzon, A.; Sharp, A.; Buxbaum, J. D.; Siper, P. M.; De Rubeis, S.
10.1101/2020.04.01.014902 — developmental biology — Posted on 2020-04-02
4450 A high-density human mitochondrial proximity interaction network.
Antonicka, H.; Lin, Z.-Y.; Janer, A.; Weraarpachai, W.; Gingras, A.-C.; Shoubridge, E. A.
10.1101/2020.04.01.020479 — cell biology — Posted on 2020-04-02
4451 Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer
Eichelberger, L.; Saini, M.; Moreno, H. D.; Klein, C.; Bartsch, J. M.; Falcone, M.; Reitberger, M.; Espinet, E.; Vogel, V.; Graf, E.; Schwarzmayr, T.; Strom, T.-M.; Lehmann, M.; Koenigshoff, M.; Pfarr, N.; Wuerth, R.; Donato, E.; Haas, S.; Spaich, S.; Suetterlin, M.; Schneeweiss, A.; Weichert, W.; Schotta, G.; Trumpp, A.; Sprick, M. R.; Scheel, C. H.
10.1101/2020.03.19.998823 — cancer biology — Posted on 2020-04-02
4453 Design and power analysis for multi-sample single cell genomics experiments
Schmid, K. T.; Cruceanu, C.; Boettcher, A.; Lickert, H.; Binder, E. B.; Theis, F. J.; Heinig, M.
10.1101/2020.04.01.019851 — bioinformatics — Posted on 2020-04-02
4455 Evolution-based design of chorismate mutase enzymes
Russ, W. P.; Figliuzzi, M.; Stocker, C.; Barrat-Charlaix, P.; Socolich, M.; Kast, P.; Hilvert, D.; Monasson, R.; Cocco, S.; Weigt, M.; Ranganathan, R.
10.1101/2020.04.01.020487 — biochemistry — Posted on 2020-04-02
4456 Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
Kan, W.; Enos, M.; Korkmazhan, E.; Muennich, S.; Chen, D.-H.; Gammons, M. V.; Vasishtha, M.; Bienz, M.; Dunn, A. R.; Skiniotis, G.; Weis, W. I.
10.1101/2020.04.01.020057 — biochemistry — Posted on 2020-04-02
4458 SnoRNA signatures in cartilage ageing and osteoarthritis
Peffers, M. J.; Chabronova, A.; Balaskas, P.; Fang, Y.; Dyer, P.; Cremers, A.; Emans, P. J.; Feczko, P. Z.; Caron, M.; Welting, T. W. J.
10.1101/2020.04.01.019505 — genomics — Posted on 2020-04-02
4464 Automated Edge-Aware Refinement of Anatomical Atlases in 3D and Its Application to the Developing Mouse Brain
Young, D. M.; Fazel Darbandi, S.; Schwartz, G.; Bonzell, Z.; Yuruk, D.; Nojima, M.; Gole, L.; Rubenstein, J. L.; Yu, W.; Sanders, S. J.
10.1101/2020.04.01.017665 — bioinformatics — Posted on 2020-04-02
4467 miR-183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids
Peskova, L.; Jurcikova, D.; Vanova, T.; Krivanek, J.; Capandova, M.; Sramkova, Z.; Kolouskova, M.; Kotasova, H.; Streit, L.; Barta, T.
10.1101/2020.04.01.019539 — molecular biology — Posted on 2020-04-02
4469 Characterizing sensitivity and coverage of clinical WGS as a diagnostic test for genetic disorders
Sun, Y.; Liu, F.; Fan, C.; Wang, Y.; Song, L.; Fang, Z.; Han, R.; Wang, Z.; Wang, X.; Yang, Z.; Xu, Z.; Peng, J.; Shi, C.; Zhang, H.; Dong, W.; Huang, H.; Li, Y.; Le, Y.; Sun, J.; Peng, Z.
10.1101/2020.04.01.019570 — genomics — Posted on 2020-04-02
4470 Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness
Slavotinek, A.; Misceo, D.; Htun, S.; Mathisen, L.; Frengen, E.; Foreman, M.; Hurtig, J. E.; Enyenihi, L.; Sterrett, M. C.; Leung, S. W.; Schneidman-Duhovny, D.; Estrada-Veras, J. I.; Duncan, J. L.; Xia, V.; Beleford, D.; Si, Y.; Douglas, G.; Treidene, H. E.; van Hoof, A.; Fasken, M. B.; Corbett, A. H.
10.1101/2020.04.01.839274 — genetics — Posted on 2020-04-02
4471 A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling
Qian, J.; Olbrecht, S.; Boeckx, B.; Vos, H.; Laoui, D.; Etlioglu, E.; Wauters, E.; Pomella, V.; Verbandt, S.; Busschaert, P.; Bassez, A.; Franken, A.; Vanden Bempt, M.; Xiong, J.; Weynand, B.; van Herck, Y.; Antoranz, A.; Bosisio, F. M.; Thienpont, B.; Floris, G.; Vergote, I.; Smeets, A.; Tejpar, S.; Lambrechts, D.
10.1101/2020.04.01.019646 — cancer biology — Posted on 2020-04-02
4475 Post-transcriptional regulation of human endogenous retroviruses by RNA-Binding Motif Protein 4, RBM4
Foroushani, A. K.; Chim, B.; Wong, M.; Rastegar, A.; Barbian, K. D.; Martens, C.; Hafner, M.; Muljo, S. A.
10.1101/2020.03.30.017111 — systems biology — Posted on 2020-04-02
4476 A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, speciation, and drug-resistance genotyping
Cunningham, C. H.; Hennelly, C. M.; Lin, J. T.; Ubalee, R.; Boyce, R. M.; Mulogo, E.; Hathaway, N.; Thwai, K. L.; Phanzu, F.; Kalonji, A.; Kashamuka, M.; Tshefu, A.; Meshnick, S. R.; Juliano, J. J.; Parr, J. B.
10.1101/2020.04.01.017962 — molecular biology — Posted on 2020-04-02
4477 Precursor intensity-based label-free quantification software tools for proteomic and multi-omic analysis within the Galaxy Platform.
Mehta, S.; Easterly, C. W.; Sajulga, R.; Millikin, R. J.; Argentini, A.; Eguinoa, I.; Martens, L.; Shortreed, M.; Smith, L. M.; McGowan, T.; Kumar, P.; Johnson, J. E.; Griffin, T.; Jagtap, P.
10.1101/2020.04.01.003988 — bioinformatics — Posted on 2020-04-02
4480 Polygenic adaptation of rosette growth variation in Arabidopsis thaliana populations
Wieters, B.; Steige, K.; He, F.; Koch, E.; Ramos-Onsins, S.; Gu, H. Y.; Guo, Y.; Sunyaev, S.; de Meaux, J.
10.1101/2020.03.31.018341 — evolutionary biology — Posted on 2020-04-02
4484 Effect of Erufosine on Membrane Lipid Order in Breast Cancer Cell Models
Tzoneva, R.; Stoyanova, T.; Petrich, A.; Popova, D.; Uzunova, V.; Momchilova, A.; Chiantia, S.
10.1101/2020.03.09.983874 — biophysics — Posted on 2020-04-02
4487 Impact of rare and common genetic variation in theInterleukin-1 pathway for human cytokine responses
van Deuren, R. C.; Arts, P.; Cavalli, G.; Jaeger, M.; Steehouwer, M.; van de Vorst, M.; Gilissen, C.; Joosten, L. A.; Dinarello, C. A.; Mhlanga, M. M.; Kumar, V.; Netea, M. G.; van de Veerdonk, F. L.; Hoischen, A.
10.1101/2020.02.14.949602 — systems biology — Posted on 2020-04-01
4488 Effects of prefrontal tDCS on dopamine-mediated behavior and psychophysiology
Imburgio, M. J.; Ballard, H. K.; Cornwall, A. C.; Worthy, D. A.; Bernard, J. A.; Orr, J. M.
10.1101/697466 — neuroscience — Posted on 2020-04-01
4491 p53 plays a central role in lymphatic anomalies
Mylavarapu, R.; Kulikauskas, M.; Dierkes, C.; Sobhani, N.; Finlon, J.; Mangette, M.; Stevens, W.; Arbab, F.; Box, N. F.; Lovell, M.; Muley, A.; Shawber, C. J.; Tamburini, B.; Kiefer, F.; Terzian, T.
10.1101/2020.03.18.992784 — developmental biology — Posted on 2020-04-01
4493 Genome architecture and transcription data reveal allelic bias during the cell cycle
Lindsly, S. M.; Jia, W.; Chen, H.; Ronquist, S.; Chen, C.; Wen, X.; Li, S. C.; Wicha, M.; Rehemtulla, A.; Muir, L.; Rajapakse, I.
10.1101/2020.03.15.992164 — genomics — Posted on 2020-04-01
4494 Identification of Conserved Evolutionary Trajectories in Tumors
Hodzic, E.; Shrestha, R.; Malikic, S.; Collins, C. C.; Litchfield, K.; Turajlic, S.; Sahinalp, C.
10.1101/2020.03.09.967257 — bioinformatics — Posted on 2020-04-01
4495 BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Bittner, Z. A.; Liu, X.; Shankar, S.; Tapia Abellan, A.; Kalbacher, H.; Andreeva, L.; Mangan, M.; Duewell, P.; Lovotti, M.; Bosch, K.; Dickhoefer, S.; Marcu, A.; Stevanovic, S.; Herster, F.; Loeffler, M. W.; Wolz, O. O.; Shilling, N. A.; Kuemmerle-Deschner, J.; Wagner, S.; Delor, A.; Grimbacher, B.; Wu, H.; Latz, E.; Weber, A. N.
10.1101/864702 — immunology — Posted on 2020-04-01
4496 Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network
Ewe, C. K.; Torres Cleuren, Y. N.; Flowers, S. E.; Alok, G.; Snell, R. G.; Rothman, J. H.
10.1101/831099 — genetics — Posted on 2020-04-01
4498 The transcription regulatory code of a maize leaf
Tu, X.; Mejia Guerra, M. K.; Franco, J. A. V.; Tzeng, D.; Chu, P.-Y.; Dai, X.; Li, P.; Buckler, E. S.; Zhong, S.
10.1101/2020.01.07.898056 — molecular biology — Posted on 2020-04-01
4500 Optoregulated force application to cellular receptors using molecular motors
Zheng, Y.; Han, M. K. L.; Zhao, R.; Blass, J.; Zhang, J.; Zhou, D. W.; Colard-Itte, J.-R.; Dattler, D.; Hoth, M.; Garcia, A. J.; Qu, B.; Bennewitz, R.; Giuseppone, N.; del Campo, A.
10.1101/2020.03.31.015198 — cell biology — Posted on 2020-04-01
4502 Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment
Chng, K. R.; Li, C.; Bertrand, D.; Ng, H. Q. A.; Kwah, J. S.; Low, H. M.; Tong, C.; Natrajan, M.; Zhang, M. H.; Xu, L.; Ko, K. K. K.; Ho, E. X. P.; Av-Shalom, T. V.; Teo, J. W. P.; Khor, C. C.; MetaSUB Consortium, ; Chen, S. L.; Mason, C. E.; Ng, O. T.; Marimuthu, K.; Ang, B.; Nagarajan, N.
10.1101/644740 — microbiology — Posted on 2020-04-01
4506 Widespread genetic effects and sex differences play a crucial role in addiction.
Saul, M. C.; Bagley, J. R.; Bailey, L. S.; Datta, U.; Dickson, P. E.; Dodd, R.; Gagnon, L. H.; Kimble, V. M.; Leonardo, M.; Kim, S.-M.; Olson, A.; Roy, T.; Schoenrock, S. E.; Wilcox, T.; Jentsch, J. D.; Logan, R. W.; McClung, C. A.; Philip, V. M.; Reinholdt, L. G.; Rizzo, S. J. S.; Tarantino, L. M.; Chesler, E. J.
10.1101/2020.02.14.949784 — neuroscience — Posted on 2020-04-01
4508 Whole-chromosome fusions in the karyotype evolution of Sceloporus (Iguania, Reptilia) are more intense in sex chromosomes than autosomes
Lisachov, A.; Tishakova, K.; Romanenko, S.; Molodtseva, A.; Prokopov, D.; Pereira, J.; Ferguson-Smith, M.; Borodin, P.; Trifonov, V.
10.1101/2020.03.31.011619 — genomics — Posted on 2020-04-01
4509 Integrating healthcare and research genetic data empowers the discovery of 28 novel developmental disorders
Kaplanis, J.; Samocha, K. E.; Wiel, L.; Zhang, Z.; Arvai, K.; Eberhardt, R.; Gallone, G.; Lelieveld, S. H.; Martin, H.; McRae, J.; Short, P.; Torene, R.; de Boer, E.; Danecek, P.; Gardner, E. J.; Huang, N.; Lord, J.; Martincorena, I.; Pfundt, R.; Reijnders, M.; Yeung, A.; Yntema, H.; DDD study, ; Vissers, L.; Juusola, J.; Wright, C.; Brunner, H.; Firth, H. V.; Fitzpatrick, D. R.; Barrett, J. C.; Hurles, M. E.; Gilissen, C.; Retterer, K.
10.1101/797787 — genomics — Posted on 2020-04-01
4510 locStra: Fast analysis of regional/global stratification in whole genome sequencing (WGS) studies
Hahn, G.; Lutz, S. M.; Hecker, J.; Prokopenko, D.; Cho, M.; Silverman, E. K.; Weiss, S.; Lange, C.
10.1101/2020.03.06.981050 — genetics — Posted on 2020-04-01
4516 Estrogen controls mTOR signaling and mitochondrial function via WNT4 in lobular carcinoma cells
Shackleford, M. T.; Rao, D. M.; Bordeaux, E. K.; Hicks, H. M.; Oesterreich, S.; Sikora, M. J.
10.1101/684530 — cancer biology — Posted on 2020-04-01
4520 Large domains of heterochromatin direct the formation of short mitotic chromosome loops
Fitz-James, M. H.; Tong, P.; Pidoux, A. L.; Ozadam, H.; Yang, L.; White, S. A.; Dekker, J.; Allshire, R. C.
10.1101/2020.04.01.019869 — cell biology — Posted on 2020-04-01
4525 Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line
Avar, M.; Heinzer, D.; Steinke, N.; Dogancay, B.; Moos, R.; Lugan, S.; Cosenza, C.; Hornemann, S.; Andreoletti, O.; Aguzzi, A.
10.1101/2020.04.01.019786 — neuroscience — Posted on 2020-04-01
4526 Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development
Ellegood, J.; Petkova, S. P.; Kinman, A.; Qiu, L. R.; Wade, A. A.; Fernandes, D. J.; Lindenmaier, Z.; Creighton, A.; Nutter, L.; Nord, A. S.; Silverman, J. L.; Lerch, J. P.
10.1101/2020.03.31.017905 — neuroscience — Posted on 2020-04-01
4527 Alterations in retrotransposition, synaptic connectivity, and myelination implicated by transcriptomic changes following maternal immune activation in non-human primates
Page, N. F.; Gandal, M.; Estes, M.; Cameron, S.; Buth, J.; Parhami, S.; Ramaswami, G.; Murray, K.; Amaral, D.; Van de Water, J.; Schumann, C. M.; Carter, C. S.; Bauman, M. D.; McAllister, A. K.; Geschwind, D. H.
10.1101/2020.03.31.019190 — neuroscience — Posted on 2020-04-01
4528 Discovery of a hidden transient state in all bromodomain families
Raich, L.; Meier, K.; Günther, J.; Christ, C. D.; Noe, F.; Olsson, S.
10.1101/2020.04.01.019547 — biophysics — Posted on 2020-04-01
4529 Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy
Summers, P. A.; Lewis, B.; Gonzalez-Garcia, J.; Lim, A. H. M.; Cadinu, P.; Porreca, R. M.; Martin-Pintado, N.; Mann, D.; Edel, J. B.; Vannier, J.-B.; Kuimova, M.; Vilar, R.
10.1101/2020.04.01.019794 — biophysics — Posted on 2020-04-01
4531 Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles
Campbell, K. M.; Steiner, G.; Wells, D. K.; Ribas, A.; Kalbasi, A.
10.1101/2020.03.30.016931 — immunology — Posted on 2020-04-01
4534 Iron is a ligand of SecA-like metal-binding domains in vivo
Cranford Smith, T.; Jamshad, M.; Jeeves, M.; Chandler, R. A.; Yule, J.; Robinson, A.; Alam, F.; Dunne, K. A.; Aponte Angarita, E. H.; Alanazi, M.; Carter, C.; Henderson, I. R.; Lovett, J. E.; Winn, P.; Knowles, T.; Huber, D.
10.1101/613315 — biochemistry — Posted on 2020-04-01
4535 Spatial Patterns for Discriminative Estimation (SPADE)
Llera Arenas, A.; Chauvin, R.; Mulders, P. C.; Naaijen, J.; Mennes, M.; Beckmann, C. F.
10.1101/746891 — neuroscience — Posted on 2020-04-01
4537 A2E induces the transactivation of RARs, PPARs and RXRs and its effects are counteracted by norbixin in retinal pigment epithelium cells in vitro
Fontaine, V.; Fournie, M.; Monteiro, E.; Boumedine, T.; Balducci, C.; Guibout, L.; Latil, M.; Dilda, P. J.; Sahel, J. A.; Veillet, S.; Lafont, R.; Camelo, S.
10.1101/2020.03.30.016071 — cell biology — Posted on 2020-04-01
4538 CeTF: an R package to Coexpression forTranscription Factors using Regulatory ImpactFactors (RIF) and Partial Correlation andInformation (PCIT) analysis
Oliveira de Biagi Junior, C. A.; Perecin Nociti, R.; Osvaldo Funicheli, B.; de Cassia Ruy, P.; Bianchi Ximenez, J. P.; Silva, W. A.
10.1101/2020.03.30.015784 — bioinformatics — Posted on 2020-04-01
4540 Impact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition
Wei, Q.; Harget, A. A.; Knoppova, B.; Duverger, A.; Ravi, R.; Shen, C.-H.; Farney, S. K.; Hall, S.; Brown, R.; Keele, B. F.; Heath, S. L.; Saag, M. S.; Kutsch, O.; Chuang, G.-Y.; Kwong, P. D.; Moldoveanu, Z.; Raska, M.; Renfrow, M. B.; Novak, J.
10.1101/2020.03.31.019091 — microbiology — Posted on 2020-04-01
4542 Analysis of biosynthesis and composition of cuticular wax in wild type bilberry (Vaccinium myrtillus L.) and its glossy mutant
Trivedi, P.; Nguyen, N.; Klavins, L.; Kviesis, J.; Heinonen, E.; Remes, J.; Jokipii-Lukkari, S.; Klavins, M.; Karppinen, K.; Jaakola, L.; Haggman, H.
10.1101/2020.04.01.019893 — plant biology — Posted on 2020-04-01
4543 Principles of mRNA control by human PUM proteins elucidated from multi-modal experiments and integrative data analysis
Wolfe, M. B.; Schagat, T. L.; Paulsen, M. T.; Magnuson, B.; Ljungman, M.; Park, D.; Zhang, C.; Campbell, Z. T.; Goldstrohm, A. C.; Freddolino, P. L.
10.1101/2020.04.01.019836 — molecular biology — Posted on 2020-04-01
4549 The Janus-faced role of KDM5B heterogeneity in melanoma: differentiation as a situational driver of both growth arrest and drug-resistance
Chauvistre, H.; Daignault, S. M.; Shannan, B.; Ju, R. J.; Picard, D.; Vogel, F. C. E.; Egetemaier, S.; Krepler, C.; Rebecca, V. W.; Sechi, A.; Kaschani, F.; Keminer, O.; Stehbens, S. J.; Varaljai, R.; Ninck, S.; Liu, Q.; Yin, X.; Jeyakumar, K.; Xiao, M.; Löffek, S.; Kubat, L.; Spassova, I.; Gul, S.; Rahmann, S.; Horn, S.; Ehrmann, M.; Paschen, A.; Becker, J. C.; Helfrich, I.; Rauh, D.; Kaiser, M.; Remke, M.; Herlyn, M.; Haass, N. K.; Dirk Schadendorf, D.; Roesch, A.
10.1101/2020.04.01.999847 — cancer biology — Posted on 2020-04-01
4551 Genetic program activity delineates risk, relapse, and therapy responsiveness in Multiple Myeloma
Wall, M. A.; Turkarslan, S.; Wu, W.-J.; Danziger, S. A.; Reiss, D. J.; Mason, M.; Dervan, A. P.; Trotter, M. W. B.; Bassett, D.; Hershberg, R. M.; Lopez Garcia de Lomana, A.; Ratushny, A.; Baliga, N. S.
10.1101/2020.04.01.012351 — systems biology — Posted on 2020-04-01
4553 Migration strategy and site fidelity of the globally threatened Sociable Lapwing Vanellus gregarius
Donald, P. F.; Kamp, J.; Green, R. E.; Urazaliyev, R.; Koshkin, M.; Sheldon, R. D.
10.1101/2020.03.31.017848 — ecology — Posted on 2020-04-01
4554 iCellR: Combined Coverage Correction and Principal Component Alignment for Batch Alignment in Single-Cell Sequencing Analysis
Khodadadi-Jamayran, A.; Pucella, J.; Zhou, H.; Doudican, N.; Carucci, J.; Heguy, A.; Reizis, B.; Tsirigos, A.
10.1101/2020.03.31.019109 — bioinformatics — Posted on 2020-04-01
4555 Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
Bakken, T. E.; Jorstad, N. L.; Hu, Q.; Lake, B. B.; Tian, W.; Kalmbach, B. E.; Crow, M.; Hodge, R. D.; Krienen, F. M.; Sorensen, S. A.; Eggermont, J.; Yao, Z.; Aevermann, B. D.; Aldridge, A. I.; Bartlett, A.; Bertagnolli, D.; Casper, T.; Castanon, R. G.; Crichton, K.; Daigle, T. L.; Dalley, R.; Dee, N.; Dembrow, N.; Diep, D.; Ding, S.-L.; Dong, W.; Fang, R.; Fischer, S.; Goldman, M.; Goldy, J.; Graybuck, L. T.; Herb, B. R.; Hou, X.; Kancherla, J.; Kroll, M.; Lathia, K.; Lew, B. v.; Li, Y. E.; Liu, C. S.; Liu, H.; Mahurkar, A.; McMillen, D.; Miller, J. A.; Moussa, M.; Nery, J. R.; Orvis, J.; Ow
10.1101/2020.03.31.016972 — neuroscience — Posted on 2020-04-01
4560 Mucin glycans signal through the sensor kinase RetS to inhibit virulence-associated traits in Pseudomonas aeruginosa
Wang, B. X.; Wheeler, K. M.; Cady, K. C.; Lehoux, S. D.; Cummings, R. D.; Laub, M. T.; Ribbeck, K.
10.1101/2020.03.31.018614 — microbiology — Posted on 2020-04-01
4561 Old drugs with new tricks: Efficacy of fluoroquinolones to suppress replication of flaviviruses
Scroggs, S. L. P.; Andrade, C. C.; Chinnasamy, R.; Azar, S. R.; Schirtzinger, E. E.; Garcia, E. I.; Arterburn, J. B.; Hanley, K. A.; Rossi, S. L.
10.1101/2020.03.30.016022 — microbiology — Posted on 2020-04-01
4565 Collapse of the hepatic gene regulatory network in the absence of FoxA factors
Reizel, Y.; Morgan, A.; Gao, L.; Lan, Y.; Manduchi, E.; Waite, E. L.; Wang, A. W.; Wells, A.; Kaestner, K. H.
10.1101/2020.03.31.016006 — genetics — Posted on 2020-04-01
4568 Staufen1 localizes to the mitotic spindle and controls the transport of RNA populations to the spindle
Hassine, S.; Bonnet-Magnaval, F.; Benoit-Bouvrette, L.-P.; Doran, B.; Ghram, M.; Bouthillette, M.; Lecuyer, E.; DesGroseillers, L.
10.1101/2020.03.31.019026 — molecular biology — Posted on 2020-04-01
4569 Schwann cell plasticity regulates neuroblastic tumor cell differentiation
Weiss, T.; Taschner-Mandl, S.; Bileck, A.; Rifatbegovic, F.; Sorger, H.; Kauer, M.; Frech, C.; Windhager, R.; Gerner, C.; Ambros, P. F.; Ambros, I. M.
10.1101/2020.04.01.019422 — cancer biology — Posted on 2020-04-01
4571 Selective Cell Propagation via Micropatterning of Thermal-activated Hydrogel
Chiu, J. C.; Teodoro, J. A.; Lee, J. H.; Matthews, K.; Duffy, S. P.; Ma, H.
10.1101/2020.04.01.019208 — bioengineering — Posted on 2020-04-01
4574 One-shot generation of duodecuple (12x) mutant Arabidopsis: Highly efficient routine editing in model species
Barthel, K.; Martin, P.; Ordon, J.; Erickson, J. L.; Gantner, J.; Herr, R.; Kretschmer, C.; Berner, T.; Keilwagen, J.; Marillonnet, S.; Stuttmann, J.
10.1101/2020.03.31.018671 — plant biology — Posted on 2020-04-01
4576 Brain-wide structural and functional disruption in mice with oligodendrocyte specific Nf1 deletion is rescued by inhibition of NOS
Asleh, J.; Shofty, B.; Cohen, N.; Kavushansky, A.; Lopez-Juarez, A.; Constantini, S.; Ratner, N.; Kahn, I.
10.1101/2020.03.31.016089 — neuroscience — Posted on 2020-04-01
4577 Greater male than female variability in regional brain structure across the lifespan
Wierenga, L. M.; Doucet, G. E.; Dima, D.; Agartz, I.; Aghajani, M.; Akudjedu, T. N.; Albajes-Eizagirre, A.; Alnaes, D.; Alpert, K. I.; Andreassen, O. A.; Anticevic, A.; Asherson, P.; Banaschewski, T.; Bargallo, N.; Baumeister, S.; Baur-Streubel, R.; Bertolino, A.; Bonvino, A.; Boomsma, D. I.; Borgwardt, S.; Bourque, J.; den Braber, A.; Brandeis, D.; Breier, A.; Brodaty, H.; Brouwer, R. M.; Buitelaar, J. K.; Busatto, G. F.; Calhoun, V. D.; Canales-Rodriguez, E. J.; Cannon, D.; Caseras, X.; Chaim-Avancini, T.; Castellanos, F. X.; Chaim-Avancini, T. M.; Ching, C. R.; Clark, V. P.; Conrod, P. J.;
10.1101/2020.02.17.952010 — neuroscience — Posted on 2020-04-01
4579 Variation at the common polysaccharide antigen locus drives lipopolysaccharide diversity within the P. syringae species complex
Jayaraman, J.; Jones, W. T.; Harvey, D.; Hemara, L. M.; McCann, H. C.; Yoon, M.; Warring, S. L.; Fineran, P. C.; Mesarich, C. H.; Templeton, M. D.
10.1101/2020.03.31.019141 — microbiology — Posted on 2020-04-01
4580 Biological characterization of Euscelidius variegatus iflavirus 1
Ottati, S.; Persico, A.; Rossi, M.; Bosco, D.; Vallino, M.; Abba', S.; Molinatto, G.; Palmano, S.; Balestrini, R.; Galetto, L.; Marzachi', C.
10.1101/2020.03.31.018010 — microbiology — Posted on 2020-04-01
4583 Convergence and novelty in adaptation to whole genome duplication in three independent polyploids
Bray, S. M.; Wolf, E. M.; Zhou, M.; Busoms, S.; Bohutinska, M.; Paajanen, P.; Monnahan, P.; Koch, J.; Fischer, S.; Koch, M. A.; Yant, L.
10.1101/2020.03.31.017939 — evolutionary biology — Posted on 2020-04-01
4584 A common analgesic enhances the anti-tumour activity of 5-aza-2'-deoxycytidine through induction of oxidative stress
Gleneadie, H. J.; Baker, A. H.; Batis, N.; Bryant, J.; Jiang, Y.; Clokie, S. J.; Mehanna, H.; Garcia, P.; Gendoo, D. M.; Roberts, S.; Molinolo, A.; Gutkind, S.; Scheven, B. A.; Cooper, P. R.; Khanim, F.; Wiench, M.
10.1101/2020.03.31.017947 — cancer biology — Posted on 2020-04-01
4586 Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity
Pinto-Fernandez, A.; Salio, M.; Partridge, T.; Chen, J.; Vere, G.; Greenwood, H.; Olie, C. S.; Damianou, A.; Scott, H. C.; Diaz-Saez, L.; Smith, P.; Gonzalez-Lopez, C.; Huber, K.; Muschel, R.; Borrow, P.; Cerundolo, V.; Kessler, B. M.
10.1101/2020.03.31.005629 — cancer biology — Posted on 2020-04-01
4588 New Soluble Angiopoietin Analog of C4BP-ANG1 Prevents Pathological Vascular Leakage
Liu, P.; Ryczko, M.; Xie, X.; Taiyab, A.; Sheardown, H.; Quaggin, S. E.; Jin, J.
10.1101/2020.03.30.016147 — biochemistry — Posted on 2020-04-01
4594 Bedscales: A non-contact adherence-independent multi-person sensor for longitudinal physiologic monitoring in the home bed
Harrington, N.; Wei, Z.; Hernandez-Pacheco, B.; Biu, Q.; DeYoung, P. N.; Duwaik, B.; Desai, A. S.; Bhatt, D. L.; Owens, R. L.; Coleman, T. P.; King, K. R.
10.1101/2020.03.31.018523 — bioengineering — Posted on 2020-04-01
4595 PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES
Spagnolli, G.; Massignan, T.; Astolfi, A.; Biggi, S.; Brunelli, P.; Libergoli, M.; Ianeselli, A.; Orioli, S.; Boldrini, A.; Terruzzi, L.; Maietta, G.; Rigoli, M.; Lopez Lorenzo, N.; Fernandez, L. C.; Tosatto, L.; Linsenmeier, L.; Vignoli, B.; Petris, G.; Gasparotto, D.; Pennuto, M.; Guella, G.; Canossa, M.; Altmeppen, H. C.; Lolli, G.; Biressi, S.; Martin Pastor, M.; Requena, J. R.; Mancini, I.; Barreca, M. L.; Faccioli, P.; Biasini, E.
10.1101/2020.03.31.018069 — biochemistry — Posted on 2020-04-01
4596 Genome and time-of-day transcriptome of Wolffia australiana link morphological extreme minimization with un-gated plant growth
Michael, T. P.; Ernst, E.; Hartwick, N.; Chu, P.; Bryant, D.; Gilbert, S.; Ortleb, S.; Baggs, E. L.; Sree, K. S.; Appenroth, K. J.; Fuchs, J.; Jupe, F.; Sandoval, J. P.; Krasileva, K. V.; Borisjuk, L.; Mockler, T. C.; Ecker, J. R.; Martienssen, R. A.; Lam, E.
10.1101/2020.03.31.018291 — plant biology — Posted on 2020-04-01
4597 Lipid droplets disrupt mechanosensing in human hepatocytes
Chin, L.; Theise, N. D.; Loneker, A. E.; Janmey, P. A.; Wells, R. G.
10.1101/2020.03.31.017319 — physiology — Posted on 2020-04-01
4600 Exogenous and endogenous HDAC inhibitor effects in Rubinstein-Taybi syndrome models
Di Fede, E.; Ottaviano, E.; Grazioli, P.; Ceccarani, C.; Parodi, C.; Colombo, E. A.; Bassanini, G.; Severgnini, M.; Milani, D.; Verduci, E.; Vaccari, T.; Massa, V.; Borghi, E.; Gervasini, C.
10.1101/2020.03.31.015800 — genetics — Posted on 2020-04-01
4603 rapidPop: Rapid population assessments of wildlife using camera trap data in R Shiny Applications
Tabak, M. A.; Lewis, J. S.; Schlichting, P. E.; Snow, N. P.; VerCauteren, K. C.; Miller, R. S.
10.1101/2020.03.30.017103 — ecology — Posted on 2020-04-01
4605 Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion
Hu, M.; Cebola, I.; Carrat, G.; Jiang, S.; Nawaz, S.; Khamis, A.; Canouil, M.; Froguel, P.; Schulte, A.; Solimena, M.; Ibberson, M.; Marchetti, P.; Cardenas-Diaz, F. L.; Gadue, P.; HASTOY, B.; Almeida-Souza, L.; McMahon, H.; Rutter, G. A.
10.1101/2020.03.31.017707 — cell biology — Posted on 2020-04-01
4607 Multiscale Co-expression in the Brain
Harris, B. D.; Crow, M.; Fisher, S.; Gillis, J.
10.1101/2020.03.31.018630 — bioinformatics — Posted on 2020-04-01
4608 SMN1 copy-number and sequence variant analysis from next generation sequencing data
Lopez-Lopez, D.; Loucera, C.; Carmona, R.; Aquino, V.; Salgado, J.; Pasalodos, S.; Miranda, M.; Alonso, A.; Dopazo, J.
10.1101/2020.03.31.014589 — bioinformatics — Posted on 2020-04-01
4609 Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis
Ribeiro, J. A.; Hammer, A.; Zuniga, G. A. L.; Chavez-Pacheco, S. M.; Tyrakis, P.; de Oliveira, G. S.; Kirkman, T.; El Bakali, J.; Rocco, S. A.; Sforca, M. L.; Parise-Filho, R.; Coyne, A. G.; Blundell, T. L.; Abell, C.; Dias, M. V. B.
10.1101/2020.03.30.016204 — biochemistry — Posted on 2020-04-01
4610 Chandelier cell anatomy and function reveal a variably distributed but common signal
Schneider-Mizell, C. M.; Bodor, A. L.; Collman, F.; Brittain, D.; Bleckert, A. A.; Dorkenwald, S.; Turner, N. L.; Macrina, T.; Lee, K.; Lu, R.; Wu, J.; Zhuang, J.; Nandi, A.; Hu, B.; Buchanan, J.; Takeno, M. M.; Torres, R.; Mahalingam, G.; Bumbarger, D. J.; Li, Y.; Chartrand, T.; Kemnitz, N.; Silversmith, W.; Ih, D.; Zung, J.; Zlateski, A.; Tartavull, I.; Popovych, S.; Wong, W.; Castro, M. A.; Jordan, C.; Froudarakis, E.; Becker, L.; Suckow, S.; Reimer, J.; Tolias, A. S.; Anastassiou, C.; Seung, H. S.; Reid, R. C.; Macarico da Costa, N.
10.1101/2020.03.31.018952 — neuroscience — Posted on 2020-04-01
4614 A bidirectional Mendelian randomization study of glycemic and anthropometric traits and Parkinsons disease
Grover, S.; Graf, R.; Noyce, A.; International Parkinsons Disease Genomics Consortium (IPDGC), ; Sharma, M.
10.1101/2020.03.31.017566 — genetics — Posted on 2020-04-01
4616 Detecting tropical selective logging with SAR data requires a time series approach
Hethcoat, M. G.; Carreiras, J. M.; Edwards, D. P.; Bryant, R. G.; Quegan, S.
10.1101/2020.03.31.018606 — ecology — Posted on 2020-04-01
4618 Parasites as niche modifiers for the microbiome: A field test with multiple parasites
O'Keeffe, K. R.; Halliday, F. W.; Jones, C. D.; Carbone, I.; Mitchell, C. E.
10.1101/2020.03.31.018713 — ecology — Posted on 2020-04-01
4619 Using spatial genetics to quantify mosquito dispersal for control programs
Filipovic, I.; Hapuarachchi, C. H.; Tien, W. P.; Muhammed, A. A. R.; Lee, C.; Tan, C. H.; Devine, G. J.; Rasic, G.
10.1101/2020.03.30.017301 — ecology — Posted on 2020-04-01
4620 Deubiquitylase UCHL3 drives error correction at kinetochores and chromosome segregation independent of spindle assembly checkpoint
Jerabkova, K.; Liao, Y.; Kleiss, C.; Fournane, S.; Durik, M.; Agote-Aran, A.; Brino, L.; Sedlacek, R.; Sumara, I.
10.1101/2020.03.31.018077 — cell biology — Posted on 2020-04-01
4622 Systematic Chemogenetic Library Assembly
Canham, S. M.; Wang, Y.; Cornett, A.; Auld, D. S.; Baeschlin, D. K.; Patoor, M.; Skaanderup, P. R.; Honda, A.; Llamas, L.; Wendel, G.; Mapa, F. A.; Aspesi, P.; Labbe-Giguere, N.; Gamber, G. G.; Palacios, D. S.; Schuffenhauer, A.; Deng, Z.; Nigsch, F.; Frederiksen, M.; Bushell, S. M.; Rothman, D.; Jain, R. K.; Hemmerle, H.; Briner, K.; Porter, J. A.; Tallarico, J. A.; Jenkins, J. L.
10.1101/2020.03.30.017244 — bioinformatics — Posted on 2020-04-01
4625 The ModelSEED Database for the integration of metabolic annotations and the reconstruction, comparison, and analysis of metabolic models for plants, fungi, and microbes
Seaver, S. M. D.; Liu, F.; Zhang, Q.; Jeffryes, J.; Faria, J. P.; Edirisinghe, J.; Mundy, M.; Chia, N.; Noor, E.; Beber, M. E.; Best, A. A.; DeJongh, M.; Kimbrel, J. A.; D'haeseleer, P.; Wood-Charlson, E. M.; Cottingham, R. W.; Arkin, A. P.; Henry, C. S.
10.1101/2020.03.31.018663 — systems biology — Posted on 2020-04-01
4628 Oxygen-glucose deprivation and reoxygenation on human cerebral organoids alters expression related to lipid metabolism
Iwasa, N.; Matsui, T. K.; Morikawa, N.; Sakaguchi, Y. M.; Shiota, T.; Iguchi, N.; Nishimura, Y.; Mori, E.; Sugie, K.
10.1101/2020.03.31.017335 — neuroscience — Posted on 2020-04-01
4631 Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
Selyutina, A.; Persaud, M.; Lee, K.; KewalRamani, V.; Diaz-Griffero, F.
10.1101/2020.03.31.018747 — microbiology — Posted on 2020-04-01
4633 AutoRELACS: Automated Generation And Analysis Of Ultra-parallel ChIP-seq
Arrigoni, L.; Ferrari, F.; Weller, J.; Bella, C.; Boenisch, U.; Manke, T.
10.1101/2020.03.30.016287 — genomics — Posted on 2020-04-01
4636 Comparative study of contact repulsion in control and mutant macrophages using a novel interaction detection
Solis-Lemus, J. A.; Sanchez-Sanchez, B. J.; Burki, M.; Marcotti, S.; stramer, b.; Reyes-Aldasoro, C. C.
10.1101/2020.03.31.018267 — cell biology — Posted on 2020-04-01
4638 Molecular Docking Analysis Of Some Phytochemicals On Two SARS-CoV-2 Targets
Ubani, A.; Agwom, F.; Shehu, N. Y.; Luka, P.; Umera, E. A.; Umar, U.; Omale, S.; Nnadi, E.; Aguiyi, J. C.
10.1101/2020.03.31.017657 — bioinformatics — Posted on 2020-04-01
4641 The MPS1 kinase NTE region has helical propensity and preferred conformations towards the TPR domain
Hiruma, Y.; Matsoukas, M.-T.; Touw, W.; Spyroulias, G.; Kops, G.; Ubbink, M.; Perrakis, A.
10.1101/2020.03.31.018036 — biochemistry — Posted on 2020-04-01
4644 An engineered Abcb4 expressing model reveals the central role of NF-κB in the regulation of drug resistance in zebrafish
Sun, C.-J.; Hu, R.-Y.; Li, Z.-C.; Jin, L.; Ye, C.; Lu, H.; Zhou, Y.-H.; Zhou, T.; He, Z.-X.; Shu, L.
10.1101/2020.03.30.016824 — zoology — Posted on 2020-04-01
4647 Regulation of light harvesting in Chlamydomonas: two protein phosphatases are involved in state transitions
Cariti, F.; Chazaux, M.; Legendre-Lefebvre, L.; Longoni, P.; Ghysels, B.; Johnson, X.; Goldschmidt-Clermont, M.
10.1101/2020.03.31.018721 — plant biology — Posted on 2020-04-01
4648 The influence of training-induced sarcomerogenesis on the history dependence of force
Chen, J.; Mashouri, P.; Fontyn, S.; Valvano, M.; Elliott-Mohamed, S.; Noonan, A. M.; Brown, S. H. M.; Power, G. A.
10.1101/2020.03.31.018895 — physiology — Posted on 2020-04-01
4649 Canonical and noncanonical features of the mouse visual cortical hierarchy
D'Souza, R.; Wang, Q.; Ji, W.; Meier, A.; Kennedy, H.; Knoblauch, K.; Burkhalter, A.
10.1101/2020.03.30.016303 — neuroscience — Posted on 2020-04-01
4651 Borrelia afzelii does not suppress the development of anti-tick immunity in bank voles
Gomez-Chamorro, A.; Li, Y.; Herrera, A.; Rais, O.; Dautel, H.; Voordouw, M. J.
10.1101/2020.03.31.018754 — microbiology — Posted on 2020-04-01
4652 A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two
Tan, C.; Hiwa, R.; Mueller, J. L.; Vykunta, V.; Hibiya, K.; Noviski, M.; Huizar, J.; Brooks, J. F.; Garcia, J.; Heyn, C.; Li, Z.; Marson, A.; Zikherman, J.
10.1101/2020.03.31.017434 — immunology — Posted on 2020-04-01
4656 Measuring ontogenetic shifts in central-place foraging insects: a case study with honey bees
Requier, F.; Henry, M.; Decourtye, A.; Brun, F.; Aupinel, P.; Rebaudo, F.; Bretagnolle, V.
10.1101/2020.03.31.017582 — ecology — Posted on 2020-04-01
4660 Digoxin Targets Central Carbon Metabolism and Remodels the Tumor Microenvironment
Sanderson, S. M.; Xiao, Z.; Wisdom, A. J.; Bose, S.; Liberti, M. V.; Reid, M. A.; Hocke, E.; Gregory, S. G.; Kirsch, D. G.; Locasale, J. W.
10.1101/2020.03.31.018739 — cancer biology — Posted on 2020-04-01