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Archive, 2025-03

3 Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation
Song, J. H.; Carter, A. C.; Bushinsky, E. M.; Beck, S. G.; Petrocelli, J. E.; Koreman, G. T.; Babu, J.; Kingsley, D. M.; Greenberg, M. E.; Walsh, C. A.
10.1101/2025.03.31.646367 — evolutionary biology — Posted on 2025-03-31
6 END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes
Yee, W.-X.; Lee, Y.-J.; Klein, T. A.; Wirganowicz, A.; Gabagat, A. E.; Csorgo, B.; Makarova, K. S.; Koonin, E. V.; Weigele, P. R.; Bondy-Denomy, J.
10.1101/2025.03.31.646159 — microbiology — Posted on 2025-03-31
7 Deep learning recognises antibiotic modes of action from brightfield images
Krentzel, D.; Kho, K.; Petit, J.; Mahtal, N.; Shorte, S. L.; Wehenkel, A. M.; Boneca, I. G.; Zimmer, C.
10.1101/2025.03.30.645928 — microbiology — Posted on 2025-03-31
8 Spatial constraints drive amylosome-mediated resistant starch degradation by Ruminococcus bromii in the human colon
Wimmer, B. H.; Morais, S.; Amit, I.; Tovar-Herrera, O.; Tatli, M.; Trautwein-Schult, A.; Tödtli, P.; Simoni, S.; Lisibach, M.; Levin, L.; Becher, D.; Bayer, E. A.; Medalia, O.; Mizrahi, I.
10.1101/2025.03.31.646359 — microbiology — Posted on 2025-03-31
9 Extracellular Vesicles Derived from Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice
Sarkar, S.; Barnaby, R.; Faber, Z.; Taub, L.; Roche, C.; Vietje, B.; Taatjes, D. J.; Wargo, M. J.; Weiss, D. J.; Bonfield, T. L.; Kelley, T. J.; Stanton, B. A.
10.1101/2025.03.30.646208 — microbiology — Posted on 2025-03-31
12 A Novel Sarocladium spinificis Strain Suppresses Coccidioides posadasii Growth: Morphological and Genetic Perspectives
Teixeira, M. M.; Ahmed, S. A.; Mead, H.; de Hoog, S.; Wiederhold, N. P.; Stajich, J. E.; Matute, D. R.; Thompson, G.; Barker, B. M.
10.1101/2025.03.31.646452 — microbiology — Posted on 2025-03-31
13 Discovery of Tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain
Bosetti, C.; Galera-Prat, A.; Sowa, S. T.; Gade, A.; Braga, C.; Brinch, S. A.; Nami, F.; Pääkkönen, J.; Pulju, V.; Waaler, J.; Clausen, M. H.; Lehtiö, L.
10.1101/2025.03.31.646301 — biochemistry — Posted on 2025-03-31
17 Defining neuronal responses to the neurotropic parasite Toxoplasma gondii
Johnson, H. J.; Kochanowsky, J. A.; Sambamurthy, C.; Hunter, C.; Beiting, D. P.; Koshy, A. A.
10.1101/2025.03.31.645603 — microbiology — Posted on 2025-03-31
22 Mosquito Sex Separation using Complementation of Selectable Traits and Engineered Neo-Sex Chromosomes
Zaada, D. S.; Toren, O.; Krsticevic, F.; Haber, D. A.; Gildman, D.; Galpaz, N.; Haecker, I.; Schetelig, M. F.; Marois, E.; Arien, Y.; Papathanos, P. A.
10.1101/2025.03.30.646185 — synthetic biology — Posted on 2025-03-31
24 Integrated Approach to Investigate Magnetite Cycle in Marine Methanic Sediments
Rivlin, A.; Bosco, A.; Boyko, V.; Shaar, R.; Zemach, Y.; Herut, B.; Henkel, S.; Weiss-Sarusi, K.; Sivan, O.
10.1101/2025.03.30.646174 — biochemistry — Posted on 2025-03-31
29 Improving eDNA filtration and purification for qPCR detection of Schistosoma mansoni in lakes Albert and Victoria
Wambui, C. W.; Viaene, M.; Mwangi, H. N.; Andre, B.; Oguttu, D. W.; Tolo, C. U.; Hellemans, B.; Huyse, T.; Gante, H. F.
10.1101/2025.03.30.646195 — molecular biology — Posted on 2025-03-31
30 Common biological features of Mycobacterium tuberculosis MmpL3 inhibitors
Ames, L.; Allen, R.; Boshoff, H. I.; Cleghorn, L.; Engelhart, C. A.; Schnappinger, D.; Parish, T.
10.1101/2025.03.31.646319 — microbiology — Posted on 2025-03-31
31 Dynamic and Heterogeneous Distribution of Trichomonasvirus Species in Trichomonas vaginalis
Luo, H.-W.; Ong, S.-C.; Syu, J.-W.; Tsai, C.-Y.; Huang, P.-J.; Lee, C.-C.; Yeh, Y.-M.; Lin, R.; Chiu, C.-H.; Tang, P.
10.1101/2025.03.31.646274 — microbiology — Posted on 2025-03-31
33 Multiscale Spatial Mapping of Microbial Communities for Biotherapeutic Development
Sehgal, P.; Shaw, A. G.; Cutler, K.; Letson, B.; Booth, G. T.; Scuderi, G. J.; Doshi, A.; Diebold, P.; Bronson, H.; Trisolini, M.; Dharaiya, U.; Keomanee-Dizon, K.; Jung, S.; Bagin, J.; Berleman, J.; Bhalla, A.; Jacoby, K.; Kujawa, S.; Mintz, J.; Murugkar, P.; Prior, M.; Robertson, K.; Burkart, A. L.; Pontin, J.; Swem, L. R.; Vlaminck, I. D.; Cheng, M. P.; Burnham, P.; Shi, H.
10.1101/2025.03.31.646377 — microbiology — Posted on 2025-03-31
34 Functional and structural characterization of a combination of pan-sarbecovirus antibodies with potent antiviral activity
Marden, G. C.; Schmitt, K. P.; Zimmerman, M. I.; Ramos, A. H.; Menzenski, M. Z.; Sharma, G.; Li, H.; Carlin, E.; Jecrois, A.; Morales-Perez, C. L.; Palovcak, E.; Garlick, J. D.; Hannigan, B.; Russell, P.; Federman, R. S.; Leung, A.; Vargas, N. L.; Shaban, N. M.; Vaidya, V.; Towler, H.; Joh, N. H.; Lord, D. M.; Tao, J.; Costello, Z.; Frappier, V.; Hopson, K.; Pegu, A.; Koh, G. C. K. W.; Van Epps, H.; Root, A.; Grigoryan, G.; Hazuda, D.; Borriello, F.
10.1101/2025.03.30.646023 — microbiology — Posted on 2025-03-31
36 The Genetic Basis of Microbiome Recruitment in Grapevine and its Association with Fermentative and Pathogenic Taxa
Floerl, L.; Lin, J.; Griggs, R. G.; Massonnet, M.; Cochetel, N.; Figueroa-Balderas, R.; Cantu, D.; Bokulich, N. A.
10.1101/2025.03.31.646331 — microbiology — Posted on 2025-03-31
37 The CCR2 inflammatory pathway is a target for improving severe disease and pulmonary inflammation in experimental COVID-19
Kazungu, Y.; Hegde, S.; Sharma, P.; Marriott, A.; Steven, A.; Reine, J.; Dagley, J. L.; Mack, M.; Stewart, J. P.; Turner, J. D.
10.1101/2025.03.28.645941 — immunology — Posted on 2025-03-31
38 Gut barrier integrity biomarkers are associated with increased inflammation and predict disease status in hospitalized COVID-19 patients
Basting, C. M.; Schroeder, T.; Ferbas, K.; Shields-Cutler, R.; Tobin, N.; Velez, A.; Swanson, E.; Broedlow, C. A.; Langat, R.; Schifanella, L.; Bramante, C. T.; Aldrovandi, G. M.; Rimoin, A.; Yang, O. O.; Fulcher, J. A.; Klatt, N. R.
10.1101/2025.03.28.645914 — immunology — Posted on 2025-03-31
39 Antibody responses against bacterial glycans affinity mature and diversify in germinal centers.
Fryer, H. A.; Pitt, C.; Frost, H. R.; Kandhari, N.; Byars, S.; Lim, P. S.; Nguyen, T. T.; Chheng, K.; Caltabiano, N.; Whitcombe, A. L.; Hamelink, J.; Andrew, D.; Lloyd, G.; Wilson-Boyd, B.; Slee, N.; Ballantine, J.; Vasani, S.; Girling, K.; Gubbels, L.; Levi, E.; Davies, K.; Tangye, S.; Noonan, J.; Moreland, N. J.; Quast, I.; Robinson, M. J.; Scally, S. W.; Neeland, M. R.; Shanthikumar, S.; Osowicki, J.; Tarlinton, D. M.; Steer, A. C.; Boyle, M. J.; Hill, D. L.
10.1101/2025.03.26.645614 — immunology — Posted on 2025-03-31
40 Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses
Huisman, W.; Azimi, S.; Nguyen, Y. N.; de Kroon, A. C.; de Ruiter, K.; Tahapary, D. L.; Manurung, M. D.; Pothast, C. R.; Kruize, Y. C. M.; Heemskerk, M. H. M.; Supali, T.; Visser, L. G.; Roukens, A. H. E.; Yazdanbakhsh, M.; Jochems, S. P.
10.1101/2025.03.28.645987 — immunology — Posted on 2025-03-31
42 α-Synuclein Activates the PI3K/AKT Pathway to Drive Lipid Droplets Accumulation: Implications for Parkinson's Disease
Abd ElHadi, S.; Congdon-Loeffler, J.; Harrosch, E.; Khatib, D.; Naamneh, L.; Schechter, M.; Eliassaf, A.; Shalev, O.; Sharon, R.
10.1101/2025.03.27.645689 — neuroscience — Posted on 2025-03-31
43 Genomic prediction of agronomic traits in perennial ryegrass (Lolium perenne L.) and genotype x environment interactions at the limit of the species distribution
Johansen, N. H.; Bellucci, A.; Hansen, P. B.; Marum, P.; Amdahl, H.; Gylstrom, K. H.; Rognli, O. A.; Kemesyte, V.; Brazauskas, G.; Greve, M.; Persson, C.; Isolahti, M.; Helgadottir, A.; Aavola, R.; Asp, T.; Ramstein, G.
10.1101/2025.03.18.642199 — genetics — Posted on 2025-03-31
46 3D vascularized microtumors unveil aberrant ccRCC vasculature and differential sensitivity to targeted treatments
Brassard-Jollive, N.; Atlas, Y.; Compere, C. L.; Ardidie-Robouant, C.; Mailly, P.; El Bouchtaoui, M.; Lelarge, V.; Blot, G.; Josseaume, N.; De Oliveira, S.; Helary, C.; Leboeuf, C.; Cremer, I.; Sibony, M.; Bousquet, G.; Germain, S.; Muller, L.; Monnot, C.
10.1101/2025.03.27.645644 — cancer biology — Posted on 2025-03-31
48 HMGB1 B-box domain self-complexes promote protein-polyelectrolyte interactions.
Kagelmacher, M.; Pigaleva, M.; Zarate, R.; Bechtella, L.; Pagel, K.; Koksch, B.; Dernedde, J.; Hermann, A.; Risse, T.
10.1101/2025.03.28.645909 — biochemistry — Posted on 2025-03-31
51 A high-resolution subcellular map of proteins in ciliated cells
Bertilsson, F.; Hikmet, F.; Hansen, J. N.; Uhlen, M.; Mear, L.; Lindskog, C.
10.1101/2025.03.18.643967 — cell biology — Posted on 2025-03-31
52 Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response
Malhi, N. K.; Luo, Y.; Tang, X.; Chadha, R. S.; Tapia, A.; Yuan, D.; Yin, S.; Chen, M.; Liu, X.; Reddy, M.; Qi, M.; Wei, L.; Cooke, J. P.; Lee, E.; Natarajan, R.; Southerland, K. W.; Chen, Z. B.
10.1101/2024.05.14.594235 — cell biology — Posted on 2025-03-31
56 Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field fMRI
Flanagan, L.; Mansur, B. d. M.; Reichert, C.; Richter, A.; Golbabaei, S.; Kizilirmak, J. M.; Sweeney-Reed, C. M.
10.1101/2024.02.14.580346 — neuroscience — Posted on 2025-03-31
57 OXPHOS TARGETING OF MYCN-AMPLIFIED NEUROBLASTOMA
Epp, S. C.; Egan, D.; Poon, E.; Abdul Aziz, A. A.; Wynne, K.; Chesler, L.; Halasz, M.; Kolch, W.
10.1101/2024.08.03.606365 — cancer biology — Posted on 2025-03-31
58 A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion
Hotchkiss, K. M.; Zhang, K.; Corcoran, A. M.; Owens, E.; Noldner, P.; Railton, C.; Van Batavia, K.; Zhou, Y.; Jepson, J.; Singh, K.; McLendon, R.; Batich, K.; Patel, A. P.; Ayasoufi, K.; Brown, M. C.; Calabrese, E.; Xie, J.; Conejo-Garcia, J.; Shaz, B. H.; Hickey, J. W.; Khasraw, M.
10.1101/2025.03.26.645566 — cancer biology — Posted on 2025-03-31
62 Glutamate indicators with increased sensitivity and tailored deactivation rates
Aggarwal, A.; Negrean, A.; Chen, Y.; Iyer, R.; Reep, D.; Liu, A.; Palutla, A.; Xie, M. E.; MacLennan, B.; Hagihara, K. M.; Kinsey, L. W.; Sun, J. L.; Yao, P.; Zheng, J.; Tsang, A.; Tsegaye, G.; Zhang, Y.; Patel, R. H.; Arthur, B. J.; Hiblot, J.; Leippe, P.; Tarnawski, M.; Marvin, J. S.; Vevea, J. D.; Turaga, S. C.; Tebo, A. G.; Carandini, M.; Rossi, L. F.; Kleinfeld, D.; Konnerth, A.; Svoboda, K.; Turner, G. C.; Hasseman, J.; Podgorski, K.
10.1101/2025.03.20.643984 — neuroscience — Posted on 2025-03-31
63 Revisiting the Central Dogma: the distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana
Zhong, Z.; Bailey, M.; Kim, Y.-I.; Pesaran-Afsharyan, N.; Parker, B.; Arathoon, L.; Li, X.; Rundle, C. A.; Behrens, A.; Nedialkova, D. D.; Slavov, G.; Hassani-Pak, K.; Lilley, K. S.; Theodoulou, F. L.; Mott, R.
10.1101/2025.01.08.631880 — plant biology — Posted on 2025-03-31
64 Metagenomic peek into a corn mummy
Solymosi, N.; Pap, B.; Nagy, S. A.; Toth, A. G.; Kevely, F. J.; Maroti, G.; Csabai, I.; Kothay, K.; Magyar, D.
10.1101/2024.07.02.601727 — bioinformatics — Posted on 2025-03-31
66 Toward De Novo Protein Design from Natural Language
Dai, F.; You, S.; Wang, C.; Fan, Y.; Su, J.; Han, C.; Zhou, X.; Liu, J.; Qian, H.; Wang, S.; Zeng, A.; Wang, Y.; Lu, H.; Yuan, F.
10.1101/2024.08.01.606258 — bioengineering — Posted on 2025-03-31
67 Sumatran orangutan mothers differ in the extent and trajectory of their expression of maternal behaviour
Revathe, T.; Mundry, R.; Utami-Atmoko, S. S.; Umaira Aprilla, T.; A. van Noordwijk, M.; Froehlich, M.; Buerkner, P.-C.; Schuppli, C.
10.1101/2024.11.25.625129 — animal behavior and cognition — Posted on 2025-03-31
69 WITHDRAWN: Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis
Lin, Z.; Wang, W.; Liu, D.; Liu, Q.; Wang, C.; Xu, Z.; Wu, Z.; Zhou, X.; Zhang, X.; Huang, Y.; Zhao, Q.; Yang, J.
10.1101/2024.04.20.590432 — microbiology — Posted on 2025-03-31
71 Barrier-Free Microhabitats: Self-Organized Seclusion in Microbial Communities
Slepukhin, V.; Peris-Yague, V.; Westendorf, C.; Koch, B.; Hallatschek, O.
10.1101/2025.03.26.645601 — biophysics — Posted on 2025-03-31
74 Astrocyte and neurogenic mechanisms of protective gene therapy prevent brain disease and death due to non-ketotic hyperglycinemia
Lopez-Ramirez, A.; Bali, A.; Alam, M. S.; Padmanabhan, P.; Calhoun, S.; Bickerton, C.; Flores-Mireles, A. L.; Haldar, K.
10.1101/2025.03.26.645560 — neuroscience — Posted on 2025-03-31
75 Geometry Linked to Untangling Efficiency Reveals Structure and Computation in Neural Populations
Chou, C.-N.; Kim, R.; Arend, L.; Yang, Y.-Y.; Mensh, B. D.; Shim, W. M.; Perich, M. G.; Chung, S.
10.1101/2024.02.26.582157 — neuroscience — Posted on 2025-03-31
77 Sex decreases the pleiotropic costs of local adaptation
Pai, S. V.; Humphrey, P. T.; Simonet, C.; Kosheleva, K.; Limdi, A.; Desai, M. M.
10.1101/2025.03.28.646016 — evolutionary biology — Posted on 2025-03-31
78 Proactive Coral Reef Restoration Using Thermally Tolerant Corals in Hawaii
Hoopai-Sylva, H.; Caruso, C.; Miller, S.; Hancock, J. R.; Parry, M.; Hughes, K.; Drury, C.
10.1101/2025.03.28.646055 — ecology — Posted on 2025-03-31
79 Alpine marmot (Marmota marmota) pups emerge increasingly earlier with the ongoing climate change
Bonenfant, C.; Cohas, A.; Quittet, P.-A.; Cavailhes, J.; Garcia, R.; Blache, N.; Gaillard, J.-M.; Douhard, M.
10.1101/2025.03.28.645887 — ecology — Posted on 2025-03-31
80 Epithelia mediate inflammation with myeloid cells in Crohn's disease patients under treatment
Zhou, R.; Xie, B.; Liu, J.; Zhao, Y.; Koval, J.; Cham, C.; Pekow, J.; Weber, C.; Chang, E.; Basu, A.
10.1101/2025.03.26.645552 — immunology — Posted on 2025-03-31
81 Standardization of postmortem human brainstem along the rostrocaudal axis to accommodate for heterogeneity in samples
Celada, M.; Zaarour, N.; Cheung, J.; Gross, C.; Lim, A.; Buchman, A. S.; Saberi, P.; Varma, G.; VanderHorst, V.
10.1101/2025.03.26.645559 — neuroscience — Posted on 2025-03-31
84 Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer
Zhang, X.; Zhang, G.; Sang, S.; Fei, Y.; Cao, X.; Song, W.; Liu, F.; Che, J.; Tao, H.; Wang, H.; Zhang, L.; Guan, Y.; Rong, S.; Pei, L.; Yao, S.; Wang, Y.; Zhang, M.; Liu, C.
10.1101/2024.05.31.596846 — cancer biology — Posted on 2025-03-31
92 Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines
Solomon, P. A. J.; Budde, M.; Kohshour, M. O.; Adorjan, K.; Heilbronner, M.; Navarro-Flores, A.; Papiol, S.; Reich-Erkelenz, D.; Schulte, E. C.; Senner, F.; Vogl, T.; Kaurani, L.; Krugger, D. M.; Sananbenesi, F.; Pena, T.; Burkhardt, S.; Schutz, A.-L.; Anghelescu, I.-G.; Arolt, V.; Baune, B. T.; Dannlowski, U.; Dietrich, D. E.; Fallgatter, A. J.; Figge, C.; Juckel, G.; Konrad, C.; Lang, F. U.; Reimer, J.; Reininghaus, E. Z.; SchmauB, M.; Spitzer, C.; Wiltfang, J.; Zimmermann, J.; Fischer, A.; Falkai, P.; Schulze, T. G.; Heilbronner, U.; Poschmann, J.
10.1101/2025.03.28.645923 — immunology — Posted on 2025-03-31
95 Modeling Masticatory Myalgia to Headache-like Referred Pain Triggers Local Gene Plasticity at Referred Pain Sites
Hovhannisyan, A. H.; Aldape, J.; Mecklenburg, J. M.; Alfaro, J. J.; Zou, Y.; Lai, Z.; Guo, W.; Yang, J.; Ernberg, M.; Boada, D. M.; Akopian, A.
10.1101/2025.03.26.645551 — neuroscience — Posted on 2025-03-31
97 Organ-level Gene Regulatory Network models enable the identification of central transcription factors in Solanum lycopersicum
Fernandez, J. D.; Navarro-Paya, D.; Santiago, A.; Cerda, A.; Canan, J.; Contreras-Riquelme, S.; Moyano, T. C.; Melet, L.; Johnson, N. R.; Alvarez, J. M.; Canales, J.; Matus, J. T.; Vidal, E. A.
10.1101/2025.03.26.645553 — systems biology — Posted on 2025-03-31
98 Functional genetics of rice PISTILLATA genes unravels new roles and targets in flowering time, female fertility and parthenocarpy
Zamzam, M.; Basak, R.; Singh, S.; Prakash, S.; Peesapati, R.; Khanday, I.; Simonini, S.; Grossniklaus, U.; Vijayraghavan, U.
10.1101/2023.08.05.552136 — plant biology — Posted on 2025-03-31
100 Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype
Hanrahan, B. J.; Chang, J. K.; Milton, A. M.; Lister, N. C.; Dissanayake, D. S. B.; Hammond, J. M.; Reis, A. L. M.; Deveson, I. W.; Ruiz-Herrera, A.; Patel, H. R.; Marshall Graves, J. A.; Georges, A.; Waters, P. D.
10.1101/2023.08.24.554710 — genomics — Posted on 2025-03-31
101 The Mycobacterium tuberculosis complex pangenome is small and shaped by sub-lineage-specific regions of difference
Behruznia, M.; Marin, M.; Whiley, D.; Farhat, M. R.; Thomas, J. C.; Domingo-Sananes, M. R.; Meehan, C. J.
10.1101/2024.03.12.584580 — evolutionary biology — Posted on 2025-03-31
104 A novel allele of Mitogen Activated Protein Kinase 6 is linked to disease resistance and constitutive immunity in rice.
C.G., G.; Mohammed, J.; Rao, D.; Gaur, N.; Supriyo, A. R.; Sao, N.; Niranjan, D.; Tiwari, S.; Laha, G. S.; Barbadikar, K. M.; Sundaram, R. M.; Maganti, S. M.; Patel, H. K.; Sonti, R. V.
10.1101/2025.03.25.645290 — plant biology — Posted on 2025-03-31
107 GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome
Knoch, K.-P.; Kosok, A.; Marinicova, Z.; Lekka, C.; Kalaidzidis, I.; Kalaidzidis, Y.; Barovic, M.; Petzold, A.; Soenmez, A.; Wegbrod, C.; Ganss, K.; Mueller, A.; Carre, A.; Scharfmann, R.; Mallone, R.; Ghosh, M.; Merl-Pham, J.; Hauck, S.; Morgan, N. G.; Richardson, S. J.; Solimena, M. J.
10.1101/2025.03.28.645506 — cell biology — Posted on 2025-03-31
109 Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control
Rodschinka, G.; Forcelloni, S.; Behrens, A.; Riemenschneider, H.; Edbauer, D.; Wani, S.; Nedialkova, D. D.
10.1101/2025.01.07.631643 — molecular biology — Posted on 2025-03-31
112 Extensive photophysiological variation in wild barley is linked to environmental origin
Breil-Aubert, M.; Shaw, K.; Royles, J.; Rodrigues Gabriel Sales, C.; Walter, J.; Taylor, G.; Vath, R.; Bdolach, E.; Dev Tiwari, L.; Mathan, J.; Lawson, T.; Fridman, E.; Kromdijk, J.; Ferguson, J. N.
10.1101/2025.03.28.645825 — plant biology — Posted on 2025-03-31
115 Prioritizing Neglected Food Species in Nutritional Studies Using Expert-Knowledge and Explainable AI
Jacob, M. C. M.; Carvalho, A. M. d.; Batista, A. G.; Santos Junior, A. d. F.; Carioca, A. A. F.; Morais, C. M. M. d.; Cazarin, C. B. B.; Tregidgo, D.; Oliveira, D. V. B. d.; Marchioni, D. M. L.; Giuntini, E. B.; Menezes-Neto, E. J. d.; Pereira, F. d. O.; Moura, G. d. F.; El Bizri, H. R.; Bezerra, I. W. L.; Aquino, J. d. S.; Silva, J. V. M.; Steluti, J.; Silva-Maia, J. K. d.; Teixeira, J. A.; Silva, L. J. G. d.; Campos, L. Z. d. O.; Oliveira, M. A.; Oliveira, M. E. G. d.; Drewinski, M. d. P.; Norde, M. M.; Menolli, N.; Lopes, P. F. M.; Silva, R. R. V. d.; Alves, R. R. N.; Silva, S. C. G. d.; Go
10.1101/2025.03.26.645402 — ecology — Posted on 2025-03-31
117 Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion
Wagner, J.; Feller, K.; Schrenke, N.; Schulze, N.; Paschen, A.; Dehmelt, L.; Nalbant, P.
10.1101/2025.03.28.646036 — cell biology — Posted on 2025-03-31
118 Root hair growth phases are coordinated by cytoskeleton, nucleus dynamics and cell mechanics in Arabidopsis
Dupouy, G.; Spelman, T.; Singh, G.; Herzog, E.; Baudrey, S.; Bovio, S.; Mutterer, J.; Hamant, O.; Berr, A.; Jonsson, H.; Chaboute, M.-E.
10.1101/2025.03.31.646268 — cell biology — Posted on 2025-03-31
122 The molecular and cellular interplay between the osteopetrosis-associated proteins SNX10, OSTM1, and CLC-7 during osteoclastogenesis
Reuven, N.; Winograd-Katz, S. E.; Barnea-Zohar, M.; Pri-Or, A.; Levin, Y.; Vacher, J.; Geiger, B.; Elson, A.
10.1101/2025.03.31.646258 — cell biology — Posted on 2025-03-31
123 Hypertrophic adipocytes increase extracellular vesicle-mediated lipid release and reprogram breast cancer cell metabolism
Beeghly, G. F.; Pincus, M. I.; Varshney, R. R.; Giri, D. D.; Falcone, D. J.; Rudolph, M. C.; Antonyak, M. A.; Iyengar, N. M.; Fischbach, C.
10.1101/2025.03.28.645549 — cell biology — Posted on 2025-03-31
124 Dual regulation of the unfolded protein response by IGF2BP3 during ER stress
Anisimova, A. S.; Hornegger, H.; Fischer, I.; Versteeg, G. A.; Ameres, S. L.; Karagoz, G. E.
10.1101/2025.03.29.646117 — cell biology — Posted on 2025-03-31
131 A reference genome assembly of the alpine forage grass Elymus nutans
Chang, D.; Jia, S.; Sun, M.; Huang, T.; Lu, H. L.; Yan, J.; Zhang, C.; You, M.; Zhang, J.; Yan, L.; Gou, W.; Lei, X.; Ji, X.; Li, Y.; Mao, D.; Wu, Q.; Li, P.; Zheng, H.; Ma, X.; Yan, X.; Liu, Q.; He, X.; Xie, W.; Li, D.; Bai, S.
10.1101/2025.03.29.645954 — plant biology — Posted on 2025-03-31
135 Plant-specific adaptations of the CDC48 unfoldase
Huntington, B.; Sandholu, A.; Wang, J.; Zhang, J.; Zhao, L.; Qureshi, B. M.; Shahul Hameed, U. F.; Arold, S. T.
10.1101/2025.03.28.645892 — plant biology — Posted on 2025-03-31
137 Mass Spectrometry-Based Characterization of Histone Post-Translational Modifications in Sugarcane
Silva, J. P. L.; Almeida-Jesus, F. M.; da Cunha, J. P.; Carneiro, M. S.; Casas-Mollano, J. A.; Hotta, C. T.
10.1101/2025.03.28.646053 — plant biology — Posted on 2025-03-31
139 In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS
Elferich, J.; Kaminek, M.; Kong, L.; Odriozola, A.; Kukulski, W.; Zuber, B.; Grigorieff, N.
10.1101/2025.03.29.646093 — biophysics — Posted on 2025-03-31
140 Oligodendrocyte precursor cells establish regulatory contacts with the soma of active neurons
Pfeiffer, F.; Boshans, L. L.; Jukkola, P.; Beebe, M.; Akinlaja, Y.; Aksoy, E. B.; Sun, Y.; Baez, C. B. R.; Hedrich, U. B. S.; Arbelo, U.; Nishiyama, A.
10.1101/2025.03.28.646001 — neuroscience — Posted on 2025-03-31
144 Novel ciliary protein TRIM8 is a multifunctional workhorse during mitosis
Bhaduri, U.; Di Venere, E.; Squeo, G. M.; Gemma, G.; Tamiro, F.; Avolio, R.; Senatore, E.; Salvemini, L.; Di Paola, R.; Licastro, D.; Iacobucci, I.; Salerno, P.; Feliciello, A.; Monti, M.; Giambra, V.; Merla, G.
10.1101/2025.03.28.646005 — cell biology — Posted on 2025-03-30
149 Layers of immunity: Deconstructing the Drosophila effector response
Ryckebusch, F.; Tian, Y.; Rapin, M.; Schupfer, F.; Hanson, M. A.; Lemaitre, B.
10.1101/2025.03.28.645959 — immunology — Posted on 2025-03-31
150 Nitrogen and oxygen isotope effects during enzymatic nitrate reduction in vitro and by natural lake water consortia
Tischer, J.; Zopfi, J.; Frey, C.; Venetz, J.; Giglio, E.; Burgdorfer, L.; Rehmann, O.; Wankel, S. D.; Lehmann, M. F.
10.1101/2025.03.29.645582 — microbiology — Posted on 2025-03-30
153 Evaluation of Engineering Potential in Undomesticated Microbes with VECTOR
Williamson, R.; Dusek, N.; Lopez-Ecartea, E.; Townsend Ramsett, M. K.; Geddes, B.
10.1101/2025.03.28.645341 — synthetic biology — Posted on 2025-03-30
156 A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway
Doherty, E. E.; Adler, B. A.; Yoon, P. H.; Hsieh, K.; Loi, K.; Armbuster, E. G.; Lahiri, A.; Bolling, C. S.; Wilcox, X. E.; Akkati, A.; Iavarone, A. T.; Pogliano, J.; Doudna, J. A.
10.1101/2025.03.28.646030 — biochemistry — Posted on 2025-03-30
157 A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem
Song, X.; Tiek, D.; Lu, M.; Yu, X.; Wu, R.; Walker, M.; He, Q.; Sisbarro, D.; Hu, B.; Cheng, S.-Y.
10.1101/2025.03.26.645511 — genomics — Posted on 2025-03-30
158 Sec61 translocon inhibitor Flavitransin blocks selectively dengue virus polyprotein insertion into the ER membrane with pan-flavivirus antiviral potency
Verhaegen, M.; Croonenborghs, M.; Sorout, N.; Sartori, A.; Provinciael, B.; Meyen, E.; Stroobants, J.; Hartmann, E.; Helms, V.; Vermeire, K.
10.1101/2025.03.29.646078 — microbiology — Posted on 2025-03-30
160 Experimental Bacterial Co-infection in Nile Tilapia Shows High Pathogenicity from Lake Kariba Isolates
Zulu, F. C.; Ndashe, K.; Changula, K.; Siamujompa, M.; Chitala, C.; Songe, M. M.; Moonga, L.; Reichley, S. R.; Hang'ombe, B. M.
10.1101/2025.03.30.646194 — microbiology — Posted on 2025-03-30
162 Pre-amyloid cognitive intervention preserves brain function in aged TgF344-AD rats, maintaining connectivity and enhancing plasticity in a sex-specific manner
Casanova-Pagola, J.; Varriano, F.; Lopez-Gil, X.; Campoy-Campos, G.; Lopez-Bravo, E.; Garcia-Gonzalez, C.; Abelli-Deulofeu, E.; Tudela, R.; Munoz-Moreno, E.; Aguado, F.; Prats-Galino, A.; Molina-Porcel, L.; Malagelada, C.; Soria, G.
10.1101/2025.03.26.645539 — neuroscience — Posted on 2025-03-30
163 Increased white matter microglial reaction and perivascular macrophages in the aging microcebe primate
Dupuis, L.; Garcia, L.; Petit, F.; Lam, S.; Hirbec, H. E.; Picq, J.-L.; Boche, D.; Dhenain, M.
10.1101/2025.03.26.645519 — neuroscience — Posted on 2025-03-30
165 Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion
Guerin, G.; Nguyen, T. L. A.; Manzi, J.; Le Clainche, C.; Heuvingh, J.; Rodriguez, N.; Cribier, S.; Berro, J.; Tsai, F.-C.
10.1101/2025.03.26.645509 — biophysics — Posted on 2025-03-30
166 Two-photon activation, deactivation, and coherent control of melanopsin in live cells
Renteria, C. A.; Boppart, S. A.; Kahng, J.; Tibble, B.; Iyer, R. R.; Shi, J. A.; Algrain, H.; Chaney, E. J.; Aksamitiene, E.; Liu, Y.-Z.; Robinson, P.; Schmidt, T. M.
10.1101/2025.03.26.645437 — bioengineering — Posted on 2025-03-30
167 Genomics and reproductive biology of Leptopilina malgretoutensis Buffington, Lue, Davis & Tracey sp. nov. (Hymenoptera: Figitidae): An asexual parasitoid of Caribbean Drosophila
Lindsey, A. R.; Lue, C.-H.; Davis, J. S.; Borjon, L. J.; Mauthner, S. E.; Fricke, L. C.; Eads, L.; Murphy, M.; Drown, M. K.; Faulk, C.; Buffington, M. L.; Tracey, W. D.
10.1101/2025.03.28.645512 — evolutionary biology — Posted on 2025-03-30
168 The nutritional value of invertebrate aquatic foods
Zamborain-Mason, J.; Marwaha, N.; Yoo, S.-H.; Hicks, C. C.; Robinson, J. P. W.; Abucay, L. R.; Elsler, L. G.; Eurich, J. G.; Friedman, W. R.; Gephart, J. A.; MacNeil, M. A.; Mason, J. G.; Palomares, M. L. D.; Parducho, V. A.; Seto, K. L.; Kleisner, K. M.; Viana, D. F.; Golden, C. D.
10.1101/2025.03.26.645521 — ecology — Posted on 2025-03-30
170 Structural basis and mechanism of action of NrdR, a bacterial master regulator of ribonucleotide reduction
Pedraz, L.; Szura, A.; Schmitz, C.; Rubio-Canalejas, A.; Santella, A.; Gomila, G.; Calo, A.; Sola, M.; Torrents, E.
10.1101/2025.03.28.645925 — molecular biology — Posted on 2025-03-30
171 The anaerobic gut fungal community in ostriches (Struthio camelus)
Vinzelj, J.; Nash, K.; Jones, A. L.; Young, R. T.; Meili, C. H.; Pratt, C. J.; Wang, Y.; Elshahed, M. S.; Youssef, N. H.
10.1101/2025.03.28.646006 — microbiology — Posted on 2025-03-30
173 A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Sullivan, A. E.; Nabhani, A.; Schinkel, K.; Dinh, D. M.; Duncan, M. L.; Ednacot, E. M. Q.; Hoffman, C. R. K.; Izrailevsky, D. S.; Kibby, E. M.; Nagy, T. A.; Nguyen, C. M.; Tak, U.; Burroughs, A. M.; Aravind, L.; Whiteley, A. T.; Morehouse, B. R.
10.1101/2025.03.28.646047 — microbiology — Posted on 2025-03-30
175 A Live Attenuated Vaccine Candidate against Emerging Highly Pathogenic Cattle-Origin 2.3.4.4b H5N1 Viruses
Mostafa, A.; Ye, C.; Barre, R. S.; Shivanna, V.; Meredith, R.; Platt, R. N.; Escobedo, R. A.; Bayoumi, M.; Castro, E. M.; Jackson, N.; Cupic, A.; Nogales, A.; Anderson, T. J.; Garcia-Sastre, A.; Martinez-Sobrido, L.
10.1101/2025.03.28.646033 — microbiology — Posted on 2025-03-30
176 A Human H5N1 Influenza Virus Expressing Bioluminescence for Evaluating Viral Infection and Identifying Therapeutic Interventions
Barre, R. S.; Escobedo, R. A.; Castro, E. M.; Cupic, A.; Bahyoumi, M.; Jackson, N.; Ye, C.; Nogales, A.; Platt, R. N.; Anderson, T. J.; Garcia-Sastre, A.; Mostafa, A.; Martinez-Sobrido, L.
10.1101/2025.03.28.646035 — microbiology — Posted on 2025-03-30
179 Echoes of 1816: Microbial Footprints in Heritage Artifacts From Argentina's Museum of Independence
Alonso-Reyes, D. G.; Galvan, F. S.; Alvarado, N.; D'Arpino, C.; Martinez, L. J.; Esquivel, H. J.; Gallardo, C. A.; Silva Manco, M. J.; Albarracin, V. H.
10.1101/2025.03.28.645971 — microbiology — Posted on 2025-03-30
180 An extracellular complex between CLE-1/collagen XV/XVIII and Punctin/MADD-4 defines cholinergic synapse identity
Cizeron, M.; Dumas, A.; Le Reun, S.; Granger, L.; Jospin, M.; Romatif, O.; Vachon, C.; Le Guern, D.; Valfort, A.-C.; Bessereau, J.-L.
10.1101/2025.03.26.645569 — neuroscience — Posted on 2025-03-30
181 Whole-brain, all-optical interrogation of neuronal dynamics underlying gut interoception in zebrafish
Chen, W.; James, B.; Ruetten, V. M. S.; Banala, S.; Wei, Z.; Fleishman, G.; Rubinov, M.; Fishman, M. C.; Engert, F.; Lavis, L. D.; Fitzgerald, J. E.; Ahrens, M. B.
10.1101/2025.03.26.645305 — neuroscience — Posted on 2025-03-30
183 Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck pain
Arendt-Tranholm, A.; Sankaranarayanan, I.; Payne, C.; Moreno, M. M.; Mazhar, K.; Yap, N.; Chiu, A. P.; Barry, A.; Patel, P. P.; Inturi, N. N.; Tavares-Ferreira, D.; Amin, A.; Karandikar, M.; Jarvik, J. G.; Turner, J. A.; Hofstetter, C. P.; Curatolo, M.; Price, T. J.
10.1101/2025.03.24.645122 — neuroscience — Posted on 2025-03-30
188 Material Damage to Multielectrode Arrays after Electrolytic Lesioning is in the Noise
Tor, A.; Clarke, S. E.; Bray, I. E.; Nuyujukian, P.; Brain Interfacing Laboratory,
10.1101/2025.03.26.645429 — neuroscience — Posted on 2025-03-30
190 Circadian Variation in Salivary Oxytocin in pre-menopausal women
Teixeira de Almeida, M.; Quattrocchi, L.; Perroud, N.; Aboulafia Brakha, T.
10.1101/2025.03.26.645423 — neuroscience — Posted on 2025-03-30
194 Neural circuit mechanisms for steering control in walking Drosophila
Rayshubskiy, A.; Holtz, S. L.; Bates, A.; Vanderbeck, Q. X.; Capdevila, L. S.; Rockwell, V.; Wilson, R. I.
10.1101/2020.04.04.024703 — neuroscience — Posted on 2025-03-30
195 Learning Binding Affinities via Fine-tuning of Protein and Ligand Language Models
Gorantla, R.; Gema, A. P.; Yang, I. X.; Serrano-Morras, A.; Suutari, B.; Jimenez, J. J.; Mey, A. S. J. S.
10.1101/2024.11.01.621495 — bioinformatics — Posted on 2025-03-30
198 Wuhan sharpbelly bornavirus (genus Cultervirus) can infect a wide range of host cells and establishes persistent infection in diverse cypriniform cells
Eshak, M. I. Y.; Breithaupt, A.; Tews, B.; Luttermann, C.; Franzke, K.; Scheibe, M.; Woelke, S.; Rubbenstroth, D.; Beer, M.; Pfaff, F.
10.1101/2025.03.26.645528 — molecular biology — Posted on 2025-03-30
199 A new class of OLD family ATPases functions in cell cycle progression in thermoacidophilic archaea
Yang, Y.; Liang, S.; Liu, J.; Fu, X.; Wu, P.; Li, H.; Ni, J.; She, Q.; Krupovic, M.; Shen, Y.
10.1101/2025.03.27.645713 — microbiology — Posted on 2025-03-30
200 Rhamnose biosynthesis is not impaired by the deletion of putative rfbC genes, slr0985 and slr1933, in Synechocystis sp. PCC 6803
Pissarra, J.; Santos, M.; B. Pereira, S.; C. Pacheco, C.; Pinto, F.; S. Ferreira, S.; Monteiro, R.; Nunes, C.; Coimbra, M. A.; Cabanes, D.; Mota, R.; Tamagnini, P.
10.1101/2025.03.27.645739 — microbiology — Posted on 2025-03-30
206 Exploring the mycovirome: novel and diverse mycoviruses in Botrytis cinerea
Drury, S. C.; Poursalavati, A.; Lemoyne, P.; Xu, D.; Moffett, P.; Carisse, O.; Van der Heyden, H.; Fall, M. L.
10.1101/2025.03.28.645015 — genomics — Posted on 2025-03-30
207 Genomic erosion through the lens of comparative genomics
Wang, X.; Fontsere, C.; Caballero, X. A.; Nielsen, S. D.; Groombridge, J.; Hansson, B.; van Oosterhout, C.; Pacheco, C.; Morales, H. E.
10.1101/2025.03.28.645899 — genomics — Posted on 2025-03-30
209 A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Iu, E.; Bogatch, A.; Deng, W.; Humphries, J. D.; Yang, C.; Valencia, F. R.; Li, C.; McCulloch, C. A.; Tanentzapf, G. D.; Svitkina, T. M.; Humphries, M. J.; Plotnikov, S. V.
10.1101/2025.03.28.646012 — cell biology — Posted on 2025-03-30
212 Polygenic Associations between Motor Behaviour, Neuromotor Traits, and Active Music Engagement in Four Cohorts
Henechowicz, T. L.; Coleman, P. L.; Gustavson, D. E.; Mekki, Y. N.; Nayak, S.; Nitin, R.; Scartozzi, A. C.; Tio, E. S.; van Klei, R.; Felsky, D.; Thaut, M. H.; Gordon, R. L.
10.1101/2025.03.27.645667 — neuroscience — Posted on 2025-03-30
214 Temporal and Spatial Scales of Resting-state Human Cortical Activity Throughout Lifespan
Bero, J.; Humphries, C.; Li, Y.; Kumar, A.; Lee, H.; Shinn, M.; Murray, J. D.; Vickery, T.; Lee, D.
10.1101/2025.03.28.645952 — neuroscience — Posted on 2025-03-30
216 α-Melanocyte Stimulating Hormone Reduces Blood Glucose Across Species
Swan, P.; Johnson, B.; Simonds, S. E.; Mustafa, T.; Houghton, M. J.; Samarasinghe, S.; Docherty, N. G.; Luli, M.; Pryor, J. T.; Greenough, C.; Gibbon, A.; Thompson, P. E.; Yue, W. K.; de Vito, G.; Williamson, G.; le Roux, C. W.; Miras, A. D.; Cowley, M. A.
10.1101/2025.03.26.645414 — physiology — Posted on 2025-03-29
221 Low extent of sex-based venom variation in Earth's most widespread viper, the common adder (Vipera berus)
Schulte, L.; Engelhardt, M.; Eichberg, J.; Cabrera-Orefice, A.; Wölfel, H.; Damm, M.; Avella, I.; Kreuels, B.; Hardes, K.; Eble, J. A.; Vilcinskas, A.; Lüddecke, T.
10.1101/2025.03.27.645687 — biochemistry — Posted on 2025-03-29
223 Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of TBX4-related Pulmonary Hypertension
Steffes, L. C.; Chiles, K.; Masud, S.; Rahman, A.; Dawson, M.; Galambos, C.; Kumar, M. E.; Arora, R.
10.1101/2025.03.26.645517 — genetics — Posted on 2025-03-29
232 scBiopsy-seq: a platform for temporal single-cell RNA-seq analysis
Cai, L.; Lin, S.; Qiu, M.; Lin, L.; Li, F.; Liu, J.; Zou, Y.; Na, X.; Liang, S.; Xu, X.; Yang, C.; Li, J.
10.1101/2025.03.26.645409 — bioengineering — Posted on 2025-03-29
233 Biocompatible Composite Hydrogel with On-Demand Swelling-Shrinking Properties for 4D Bioprinting
Jensen, P. J.; Graham, J. P.; Busch, T. K.; Fitz, O. R.; Jayanadh, S.; Pashuck, E. T.; Gonzalez-Fernandez, T.
10.1101/2025.03.26.645296 — bioengineering — Posted on 2025-03-29
234 RNA sequence analysis of somatic mutations in aging and Parkinson's Disease
Sun, S.; Sproviero, D.; Payan-Gomez, C.; Hoeijmakers, J.; Maslov, A. Y.; Mastroberardino, P. G.; Vijg, J.
10.1101/2025.03.26.645360 — genetics — Posted on 2025-03-29
235 From Shadows to Data: A Robust Population Assessment of Snow Leopards in the Highland Crossroads
Nawaz, M. A. A.; Hameed, S.; Din, J. U.; Ali, H.; Ahmad, S.; Durbach, I.; Ghaznavi, M.; Farooque, M.; Iftikhar, N.; Hussain Khan, M. S.
10.1101/2025.03.26.645478 — ecology — Posted on 2025-03-29
238 CHD7 binds to insulators during neuronal differentiation
Qiu, J.; Jadali, A.; Martinez, E.; Song, Z.; Ni, J. Z.; Kwan, K. Y.
10.1101/2025.03.28.646031 — molecular biology — Posted on 2025-03-29
240 Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
Hariharan, V. N.; Summers, A.; Caiazzi, J.; Hildebrand, S.; OReilly, D.; Tang, Q.; Kennedy, Z.; Echeverria, D.; McHugh, N.; Cooper, D.; Sousa, J.; Ferguson, C.; Clipperton-Allen, A.; Bogdanik, L.; Coenraads, M.; Khvorova, A.
10.1101/2025.03.26.645328 — neuroscience — Posted on 2025-03-29
250 SAXS reveals the molecular basis underlying pH-driven G3BP1 conformational dynamics: implications for stress granule formation
Han, X.; Sun, R.; Graewert, M. A.; Zhou, Q.; Resink, T.; Blanchet, C.; Ljunggren, H.-G.; Alici, E.; McInerney, G. M.; Farnebo, M.; Svergun, D.; Achour, A.
10.1101/2025.03.27.645651 — molecular biology — Posted on 2025-03-29
253 Discovery and isolation of novel capsaicinoids and their TRPV1-related activity
Smith, J.; Stillerova, V. T.; Dracinsky, M.; Popr, M.; Gaustad, H. L. A.; Lorenzi, Q.; Smrckova, H.; Reinardt, J. K.; Lienard, M. A.; Bednarova, L.; Sacha, P.; Pluskal, T.
10.1101/2024.10.29.620944 — pharmacology and toxicology — Posted on 2025-03-29
254 Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma
Pellinen, T.; Luomala, L.; Mattila, K. E.; Hemmes, A.; Valimaki, K.; Bruck, O.; Paavolainen, L.; Kankkunen, E.; Nisen, H.; Jarvinen, P.; Castillon, L.; Vanharanta, S.; Vainio, P.; Kallioniemi, O.; Jaakkola, P. M.; Mirtti, T.
10.1101/2024.10.27.620479 — cancer biology — Posted on 2025-03-29
257 Suspended Tissue Open Microfluidic Patterning (STOMP)
Haack, A. J.; Brown, L. G.; Goldstein, A. J.; Mulimani, P.; Berthier, J.; Viswanathan, A. R.; Kopyeva, I.; Whitten, J. M.; Lin, A.; Nguyen, S. H.; Leahy, T. P.; Bouker, E. E.; Padgett, R. M.; Mazzawi, N. A.; Tokihiro, J. C.; Bretherton, R. C.; Wu, A.; Tapscott, S. J.; DeForest, C. A.; Popowics, T. E.; Berthier, E.; Sniadecki, N. J.; Theberge, A. B.
10.1101/2024.10.04.616662 — bioengineering — Posted on 2025-03-29
258 Arrestin recognizes GPCRs independently of the receptor state
Petrovic, I.; Tatli, M.; Desai, S.; Grahl, A.; Ni, D.; Stahlberg, H.; Spang, A.; Grzesiek, S.; Abiko, L. A.
10.1101/2024.07.19.604263 — biochemistry — Posted on 2025-03-29
259 Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue
Cheng, Y.; Dang, S.; Zhang, Y.; Chen, Y.; Yu, R.; Liu, M.; Jin, S.; Han, A.; Katz, S.; Wang, S.
10.1101/2025.03.06.641951 — genetics — Posted on 2025-03-29
262 Condensates of synaptic vesicles and synapsin are molecular beacons for actin sequestering and polymerization
Chhabra, A.; Hoffmann, C.; Aguilar Perez, G.; Korobeinikov, A.; Rentsch, J.; Huempfer, N.; Kokwaro, L.; Gnidovec, L.; Petrovic, A.; Wallace, J.; Tromm, J. V.; Cristina, R.-V.; Johnson, E.; Rankovic, B.; Perego, E.; Volpi, T.; Fernandez-Busnadiego, R.; Koester, S.; Rizzoli, S.; Ewers, H.; Morgan, J.; Milovanovic, D.
10.1101/2024.07.19.604346 — cell biology — Posted on 2025-03-29
263 Reactive Oxygen Species Counteract Wound Contraction and Promote Wound Healing
Ding, C.; Li, L.; Wang, Y.; Nguyen, H.-A. A.; Chan, D.; Umulis, D. M.; Tepole, A. B.; Deng, Q.
10.1101/2025.03.27.645726 — cell biology — Posted on 2025-03-29
266 Differing genetics of saline and cocaine self administration in the hybrid mouse diversity panel
Khan, A. H.; Bagley, J. R.; LaPierre, N. R. S.; Gonzalez-Figueroa, C.; Spencer, T. C.; Choudhury, M.; Xiao, X. G.; Eskin, E.; Jentsch, J. D.; Smith, D. J.
10.1101/2024.12.04.626933 — genetics — Posted on 2025-03-29
268 Histone lactylation: a new epigenetic mark in the malaria parasite Plasmodium
Jabre, I.; Andoh, N. E.; Naldoni, J.; Gregory, W. F.; Yoon, C. E.; Cunnington, A. J.; Georgiadou, A.; Blagborough, A. M.; Merrick, C. J.
10.1101/2024.08.19.608576 — microbiology — Posted on 2025-03-29
272 Sheltered load in fungal mating-type chromosomes revealed by fitness experiments
Guyot, L.; Chahine, E.; De Filippo, E.; Lalanne, C.; Brun, S.; Hartmann, F. E.; Giraud, T.
10.1101/2024.09.10.612177 — evolutionary biology — Posted on 2025-03-29
274 IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S.; Viragova, S.; Koga, S.; Liu, M.; O'Leary, C.; Ricardo-Gonzalez, R. R.; Schroeder, A. W.; Kochhar, N.; Klein, O.; Diamond, M.; Liang, H.-E.; Locksley, R. M.
10.1101/2025.03.25.645270 — immunology — Posted on 2025-03-29
275 Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility
Lee, O. V.; Ji, D. X.; Rosa, B. A.; Jaye, D. L.; Suliman, S.; Mitreva, M.; Gabay, C.; Vance, R. E.; Kotov, D. I.
10.1101/2023.10.27.564420 — immunology — Posted on 2025-03-29
277 Sex differences in human IgG1-mediated angiogenesis inhibition depend on Y chromosome-encoded DDX3Y
Argyle, D. A.; Dholkawala, R.; Makin, R. D.; Pereira, F.; Nagasaka, Y.; Huang, P.; Wang, S.-B.; Apicella, I.; Arneja, A.; Luckey, C. J.; Walsh, K. A.; Arnold, A. P.; Ambati, J.; Gelfand, B. D.
10.1101/2025.03.25.645206 — pathology — Posted on 2025-03-29
278 Wnt/Beta-Catenin Signaling Is Active in Neuroendocrine Prostate Cancer
Shi, Y.; Yang, S.; Li, L.; Cheng, S.; Sivalingam, J.; Mahdavian, E.; Yu, X.
10.1101/2025.03.25.645248 — cancer biology — Posted on 2025-03-29
279 Deep Spatial Sequencing Revealing Differential Immune Responses in Human Hepatocellular Carcinoma
Yu, Y.; Liu, S.; Obert, C.; Ren, B.-G.; Krivet, M.; Metcalfe, K.; Liu, J.-J.; Ben-Yehezkel, T.; Luo, J.
10.1101/2025.03.25.645292 — cancer biology — Posted on 2025-03-29
281 The spontaneous neoantigen-specific CD4+ T cell response to a growing tumor is functionally and phenotypically diverse.
Griswold, R.; Brightman, S.; Zavala, K. S.; Ordaz-Arias, M. A.; Djassemi, N.; Thota, R.; Naradikian, M.; Dose, H.; Alarcon, S.; Vijayanand, P.; Peters, B.; Miller, A.; Cohen, E.; Schoenberger, S.
10.1101/2025.03.25.645281 — immunology — Posted on 2025-03-29
282 Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner.
Akbar, I.; Doss, P. M. I. A.; Baillargeon, J.; Fazazi, M. R.; Anderson, A. C.; Lassmann, H.; Rangachari, M.
10.1101/2025.03.25.645315 — immunology — Posted on 2025-03-29
286 The dispersal of domestic cats from Northern Africa and their introduction to Europe over the last two millennia
De Martino, M.; De Cupere, B.; Rovelli, V.; Serventi, P.; Baldoni, M.; Di Corcia, T.; Geiger, S.; Alhaique, F.; Alves, P.; Buitenhuis, H.; Ceccaroni, E.; Cerilli, E.; De Grossi-Mazzorin, J.; Detry, C.; Dowd, M.; Fiore, I.; Gourichon, L.; Grau-Sologestoa, I.; Kuchelmann, H. C.; Kunst, K. G.; McCarthy, M.; Micciche, R.; Minniti, C.; Moreno, M.; Onar, V.; Oueslati, T.; Parrag, M.; Pino Uria, B.; Romagnoli, G.; Rugge, M.; Salari, L.; Saliari, K.; Santos, A.; Schmolcke, U.; Sforzi, A.; Soranna, G.; Spassov, N.; Tagliacozzo, A.; Tine, V.; Trixl, S.; Vukovic, S.; Wierer, U.; Wilkens, B.; Doherty, S.;
10.1101/2025.03.28.645893 — evolutionary biology — Posted on 2025-03-29
291 Neural correlates in basolateral and central amygdala during reward seeking in the face of punishment
Minier-Toribio, A.; Sadacca, B.; Corruble, E.; David, D.; Shaham, Y.; Schoenbaum, G.; Pelloux, Y.
10.1101/2025.03.26.645435 — neuroscience — Posted on 2025-03-29
292 Auditory regulation of hippocampal locomotion circuits by a non-canonical reticular-limbic pathway
LEAO, R. N.; Winne, J.; Leao, K. E.; Kullander, K.; Nascimento, G.; Pedrosa, R.; Simoes, C.; Nogueira, M.
10.1101/2025.03.26.645464 — neuroscience — Posted on 2025-03-29
296 Redefining the timing and circumstances of cat domestication, their dispersal trajectories, and the extirpation of European wildcats
Doherty, S.; Krajcarz, M.; Carmagnini, A.; Dimopoulos, E.; Jamieson, A.; Alves, J. M.; Balasescu, A.; Baker, P.; Baranowski, P.; Beglane, F.; Bitz-Thorsen, J.; Bolton, A.; Bowden, W.; Britton, H.; De Cupere, B.; De Martino, M.; Donnelly-Symes, B.; Evin, A.; Fowler, T.; Fulford, M.; Gotfredsen, A. B.; Han, Y.; Kitchener, A. C.; Knapp, Z.; Luo, S.-J.; Mainland, I.; Maricevic, D.; Moody, S.; Nesnidaloa, T.; O'Connor, T.; Orton, D. C.; Peters, J.; Sadebeck, F.; Siegenthaler, A.; Smallman, R.; Suvova, Z.; Symmons, R.; Sudds, J.; Thomas, G.; Van Neer, W.; Wilczynski, J.; Ottoni, C.; Popovic, D.; Fra
10.1101/2025.03.28.645877 — zoology — Posted on 2025-03-29
298 Helminth infection favors reprogramming and proliferation of lung neutrophils
Chen, F.; Batirbek, S. B.; Espinosa, V.; Jin, L.; Wang, K.; Wu, W.; Johnson, W. E.; Lemenze, A.; Messyasz, A.; Siracusa, M.; Parker, D.; Rivera, A.; Gause, W.
10.1101/2025.03.25.645229 — immunology — Posted on 2025-03-29
299 Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus
Mandell, K. A. P.; Simmons, S. K.; Nadig, A.; Farsi, Z.; Huang, W.-C.; Aryal, S.; Kwon, M. J.; Song, B.; Brenner, K.; Shepard, N.; Nicolella, A. A.; O'Brien, L. D.; Lichtman, A. H.; Levin, J. Z.; Sheng, M.
10.1101/2025.03.26.645496 — neuroscience — Posted on 2025-03-29
300 A dynamic gene regulatory code drives synaptic development of hippocampal granule cells
Lorente-Echeverria, B.; Daaboul, D.; Vandensteen, J.; Marcassa, G.; Naert, W.; Vandenbempt, J.; Leysen, E.; Reverendo, M.; Vlaeminck, I.; Vervloessem, L.; Lamote, J.; Poovathingal, S.; Davie, K.; Wierda, K.; Dascenco, D.; Aerts, S.; de Wit, J.
10.1101/2025.03.27.645686 — neuroscience — Posted on 2025-03-29
302 Non-destructive radiocarbon dating of bone
Higham, T. F.; Luftensteiner, K.; van der Sluis, L.; Gianni, M.; Steier, P.; Belinski, A.; Mensan, R.; Kozlikin, M.; Shunkov, M.; Schulze, J.; Douka, K.; Stafford, T.
10.1101/2025.03.26.645488 — paleontology — Posted on 2025-03-29
303 Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signalling
Tandon, V.; Fistrovich, A. H.; Nogales, J.; Ferro, F.; Rokey, S. N.; Cabel, C. R.; Miller, A. D.; Yagle, M.; Duncan, C.; Atmasidha, A.; Sharma, I.; Wilms, G. F.; Williams, K.; Elliott, R. J. R.; Chavez, T.; Shaw, Y. J.; McMahon, A. P.; Ginn, S. B.; Basantes, L. E.; Bedard, N.; Gokhale, V.; Ellis, N. A.; Prescott, A. R.; Smith, S. J.; Rahman, R.; Becker, W.; Read, K. D.; Chalmers, A. J.; Carragher, N.; Masson, G. R.; Montfort, W. R.; Thorne, C. A.; Hulme, C.; Banerjee, S.
10.1101/2025.03.26.645490 — cancer biology — Posted on 2025-03-29
304 The PXBAR-domain protein SNX9 selectively sequesters PI(3,4)P2 lipid and protects it from hydrolysis at the plasma membrane
Beiter, J.; Sung, C.-J.; Lin, S.-S.; DeVuono, N.; Arumugam, S.; Manzi, J.; Bertin, A.; Bassereau, P.; Liu, Y.-W.; Voth, G. A.; Tsai, F.-C.
10.1101/2025.03.26.645564 — biophysics — Posted on 2025-03-29
306 Chromosome-level genome assemblies for the latent pine pathogen, Diplodia sapinea, reveal two rapidly evolving accessory chromosomes
Duong, T. A.; Shaw, P. L.; Slippers, B.; Wingfield, B. D.; Laurent, B.; Penaud, B.; Wingfield, M. J.; Crous, P. W.; Bihon, W.
10.1101/2025.03.26.645563 — genomics — Posted on 2025-03-29
308 Scaling up tree diversity inventories across Amazonian ecosystems using field spectroscopy
Hadlich, H. L.; Schongart, J.; Wittmann, F.; Vasconcelos, C. C.; Mallmann, C.; Conde, M. L. G.; Amaral de S, P.; Demarchi, L. O.; Mori, G. B.; Piedade, M. T. F.; Durgante, F. M.
10.1101/2025.03.26.645444 — ecology — Posted on 2025-03-29
311 Shoc2 Deficiency Disrupts Lymphangiogenesis through mTOR-Mediated Mitochondrial Dysfunction
Wilson, P.; Vishwakarma, V.; Norcross, R.; Khaire, K. S.; Pham, V. N.; Jung, H. M.; Weinstein, B. M.; Galperin, E.
10.1101/2025.03.26.645567 — developmental biology — Posted on 2025-03-29
312 Multiple Wnt signaling pathways direct epithelial tubule interconnection in the regenerating zebrafish kidney
Kamei, C. N.; Sampson, W. G. B.; Albertz, C.; Aries, O.; Wolf, A.; Upadhyay, R.; Hughes, S.; Schenk, H.; Bonnet, F.; Draper, B. B. W.; McCracken, K.; Marciano, D.; Oxburgh, L.; Drummond, I. A.
10.1101/2025.03.26.645545 — developmental biology — Posted on 2025-03-29
313 Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties
Gupta, A.; Sinha, B.; Sengupta, D.; Chatterjee, S. K.; Kar, S.; Nikte, S.; Dash, T.; Maji, S.; Ghosh, T.
10.1101/2025.03.28.645880 — cell biology — Posted on 2025-03-29
318 Genomic and Transcriptomic Signatures of SETD1A Disruption in Human Excitatory Neuron Development and Psychiatric Disease Risk
Sun, Z.; Zhu, H.; He, X.; Lendemeijer, B.; Wang, Z.; Fan, J.; Sun, Y.; Zhang, Z.; Markx, S.; Kushner, S. A.; Xu, B.; Gogos, J. A.
10.1101/2025.03.26.645419 — neuroscience — Posted on 2025-03-29
319 Sensitivity analysis enlightens effects of connectivity in a Neural Mass Model under Control-Target mode
Vallet, A.; Blanco, S.; Chevallier, C.; Eustache, F.; Gautrais, J.; Grandpeix, J.-Y.; Joly, J.-L.; Segobin, S.; Gagnepain, P.
10.1101/2025.03.26.645487 — neuroscience — Posted on 2025-03-29
320 Long-term, age-associated activity quantification in the DE50-MD dog model of Duchenne muscular dystrophy (DMD)
Karimjee, K.; River, R. C. M.; Olsen, E.; Chang, Y.-M.; Wells, D. J.; Daley, M. A.; Piercy, R. J.
10.1101/2025.03.26.645481 — neuroscience — Posted on 2025-03-29
321 Alectinib enhances response to RBM39 degradation via SRPK1 inhibition
Ma, Y.; Poon, E.; Jin, C.; Martins da Costa, B.; Xu, Y.; Quazi, S.; Zourdoumis, N.; Wickremesinghe, C.; Chesler, L.; Keun, H. C.; Nijhuis, A.
10.1101/2025.03.28.644532 — cancer biology — Posted on 2025-03-28
322 Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR
He, C.; Varghese, N. R.; Keeler, E. G.; Pham, C. L. L.; Williams, B.; Tetter, S.; Semaan, C.; Wilde, K. L.; Brown, S. H. J.; Bouwer, J. C.; Gambin, Y.; Sierecki, E.; Steain, M.; Sunde, M.; McDermott, A. E.
10.1101/2025.03.26.644761 — biophysics — Posted on 2025-03-29
326 Haplotype-resolved reference genomes of the sea turtle clade unveil ultra-syntenic genomes with hotspots of divergence
Arantes, L. S.; Brown, T.; De Panis, D.; Whiting, S. D.; LaCasella, E. L.; Carvajal, G. A.; Kennedy, A.; Edmunds, D.; Bentley, B. P.; Balacco, J.; Whelan, C.; Jain, N.; Tilley, T.; O'Toole, B.; Traore, P.; Jarvis, E. D.; Berry, O.; Dutton, P. H.; Komoroske, L. M.; Mazzoni, C. J.
10.1101/2025.03.26.644878 — genomics — Posted on 2025-03-28
328 Adaptive Increase of Amylase Gene Copy Number in Peruvians Driven by Potato-rich Diets
Scheer, K.; Landau, L. J. B.; Jorgensen, K.; Karageorgiou, C.; Siao, L.; Alkan, C.; Morales-Rivera, A. M.; Osbourne, C.; Garcia, O.; Pearson, L.; Kiyamu, M.; Leon-Velarde, F.; Rivera-Chira, M.; Lee, F.; Brutsaert, T.; Bigham, A.; Gokcumen, O.
10.1101/2025.03.25.644684 — genetics — Posted on 2025-03-29
330 Axial patterning of gastruloids via diverse cell type compositions
Anlas, K.; Nakaki, F.; Gritti, N.; Font-Reverter, J.; Arato, K.; Planasdemunt-Hospital, M.; Oriola, D.; Sharpe, J.; Trivedi, V.
10.1101/2025.03.26.645494 — developmental biology — Posted on 2025-03-29
332 Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1
Zhang, L.; Gottschalk, B.; Dietsche, F.; Bitar, S.; Bueno, D.; Rojas-Charry, L.; Kumari, A.; Garg, V.; Graier, W. F.; Methner, A.
10.1101/2025.03.28.645939 — cell biology — Posted on 2025-03-29
334 Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure
Sobhani, I.; De Oliveira Alves, N.; Sadeghi, M.; Charpy, C.; Bergsten Emma, E.; Amiot, A.; Barau, C.; Brunetti, F.; Vaysse, A.; Tournigand, C.; Chamaillard, M.; Khashayarsha, K.; Mestivier, D.
10.1101/2025.03.25.645177 — immunology — Posted on 2025-03-28
335 Two distinct cytokine response clusters identified in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis despite sustained occupational exposure
Balfour, A.; Masina, N.; Queiroz, A.; Andrade, B.; Fukutani, E.; Bekiswa, A.; Lewinsohn, D.; Lewinsohn, D.; Goliath, R.; Wilkinson, K. A.; Schutz, C.; Meintjes, G.; Shey, M. S.
10.1101/2025.03.27.643001 — immunology — Posted on 2025-03-28
336 Dendritic-cell diversity in equine blood revealed by single-cell transcriptomics
Botos, M.; Baillou, A.; Oberhaensli, S.; Cvitas, I.; Jonsdottir, S.; Ziegler, A.; Brito, F.; Summerfield, A.; Marti, E.; Talker, S. C.
10.1101/2025.03.27.644174 — immunology — Posted on 2025-03-28
338 Dynamic structural connectivity changes in cortical and cortico-striatal strokes in mice
Mahani, F.; Kalantari Sarcheshmeh, A.; Diedenhofen, M.; Green, C.; Wiedermann, D.; Fink, G. R.; Hoehn, M.; Aswendt, M.
10.1101/2025.03.27.644898 — neuroscience — Posted on 2025-03-28
341 Sympathetic nociceptive afferent signaling drives the chronic structural and functional autonomic remodeling after myocardial infarction
Van Weperen, V.; Hoang, J. D.; Jani, N.; Atmani, K.; Chan, C. A.; Cao, K.; Avasthi, S.; Lokhandwala, Z. A.; Emamimeybodi, M.; Vaseghi, M.
10.1101/2025.03.28.645120 — physiology — Posted on 2025-03-28
342 Archaeological Bone Assemblages Trace Changes in Turtle and Tortoise Diversity in Continental Southeast Asia
Bochaton, C.; Wilailuck, N.; Chantasri, S.; Maneechote, M.; Mithong, S.; Sophady, H.; Auetrakulvit, P.; Forestier, H.; Zeitoun, V.; Bowonsachoti, J.; Claude, J.
10.1101/2025.03.27.645446 — paleontology — Posted on 2025-03-28
343 Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
Whiting, F. J. H.; Mossner, M.; Gabbutt, C.; Kimberley, C.; Barnes, C. P.; Baker, A.-M.; Yara, E.; Sottoriva, A.; Nichols, R. A.; Graham, T. A.
10.1101/2025.03.26.645251 — cancer biology — Posted on 2025-03-28
344 Reactive oxygen generation by minimal copper binding peptide motifs
Vayyattil, V.; Sharma, R.; Gielnik, M. B.; Lock, N.; Kjaergaard, M.
10.1101/2025.03.26.645443 — biophysics — Posted on 2025-03-28
345 Counting particles could give wrong probabilities in Cryo-Electron Microscopy
Evans, L.; Dingeldein, L.; Covino, R.; Gilles, M. A. T.; Thiede, E.; Cossio, P.
10.1101/2025.03.27.644168 — biophysics — Posted on 2025-03-28
347 A Novel Human Distal Tubuloid-On-A-Chip Model For Investigating Sodium And Water Transport Mechanisms
Dorileo Leite Bernardi, M. D. L.; Dilmen, E.; Kurek, D.; Lanz, H.; Joore, J.; Hoenderop, J.; Rookmaaker, M. B.; Verhaar, M. C.
10.1101/2025.03.27.644139 — bioengineering — Posted on 2025-03-28
349 Construction of Complete Telomere-to-Telomere Genome Assembly of the Rabbit Using Haploid Embryonic Stem Cells
A, Y.; Mao, J.; Hu, S.; Yu, M.; Yang, Y.; Zhang, Y.; Qiu, T.; Quan, L.; Zhao, H.; Zhang, Q.; Yu, K.; Ye, Y.; Yan, H.; Li, N.; Yang, X.; Yang, X.; Zhang, R.; Zhai, G.; Wang, M.; Lai, L.
10.1101/2025.03.26.645123 — genomics — Posted on 2025-03-28
352 Vulnerability to memory decline in aging. A mega-analysis of structural brain change.
Vidal-Pineiro, D.; Sorensen, O.; Stromstad, M.; Amlien, I. K.; Baare, W. F. C.; Bartres-Faz, D.; Brandmaier, A. M.; Cattaneo, G.; Duzel, S.; Ghisletta, P.; Henson, R. N.; Kuhn, S.; Lindenberger, U.; Mowinckel, A. M.; Nyberg, L.; Pascual-Leone, A.; Roe, J. M.; Solana-Sanchez, J.; Sole-Padulles, C.; Watne, L.-O.; Wolfers, T.; Walhovd, K. B.; Fjell, A. M.
10.1101/2025.03.27.642988 — neuroscience — Posted on 2025-03-28
353 A therapeutic role for a regulatory glucose transporter1 (Glut1)-associated natural antisense transcript
Tang, M.; Teng, S.; Peng, Y.; Kim, A. Y.; Canoll, P.; Bruce, J. N.; Faust, P. L.; Adhikari, K.; De Vivo, D. C.; Monani, U. R.
10.1101/2025.03.26.644647 — neuroscience — Posted on 2025-03-28
354 A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature
Marshe, V. S.; Tuddenham, J. F.; Chen, K.; Chiu, R.; Haage, V. C.; Ma, Y.; Lee, A. J.; Shneider, N. A.; Agin-Liebes, J. P.; Alcalay, R. N.; Teich, A. F.; Canoll, P.; Riley, C. S.; Keene, D.; Schneider, J. A.; Bennett, D. A.; Menon, V.; Taga, M.; Klein, H.-U.; Olah, M.; Fujita, M.; Zhang, Y.; Sims, P. A.; De Jager, P. L.
10.1101/2025.03.27.641500 — neuroscience — Posted on 2025-03-28
355 Identification of BET Inhibitors (BETi) Against Solitary Fibrous Tumor (SFT) Through High-Throughput Screening (HTS)
Mondaza-Hernandez, J. L.; Moura, D. S.; Li, Y.; Lopez-Marti, J.; Gomez-Puertas, P.; Nguyen, J. T.; Wei, S.; Posner, B. A.; Meyer, C. A.; Bleris, L.; Martin-Broto, J.; Hayenga, H.
10.1101/2025.03.25.645256 — cancer biology — Posted on 2025-03-28
358 Structural basis for selective inhibition of human GABA transporter GAT3
Mortensen, J. S.; Bavo, F.; Pedersen, A. P. S.; Storm, J. P.; Pape, T. H.; Frolund, B.; Wellendorph, P.; Shahsavar, A.
10.1101/2025.03.27.645797 — molecular biology — Posted on 2025-03-28
359 N6-methyladenosine primes the malaria parasite for transmission
Mussgnug, S.; Vignolini, T.; Couble, J.; Chen, P.; Farhat, D.; Sinha, A.; Dore, G.; Dupre, D.; Lambault, M.; Hadj Abed, L.; Preiser, P.; Dedon, P.; Bryant, J.; Baumgarten, S.
10.1101/2025.03.28.645929 — molecular biology — Posted on 2025-03-28
360 RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages
Freitas-Filho, E. G.; Zaidan, I.; Fortes-Rocha, M.; Alzamora-Terrel, D. L.; Bifano, C.; Castro, P. A.; Piraine, R. E. A.; Pinzan, C. F.; Rezende, C. P.; Boada-Romero, E.; Almeida, F. B. R.; Goldman, G.; Florey, O.; Cunha, L. D.
10.1101/2025.03.25.645097 — immunology — Posted on 2025-03-28
363 Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
Wilmes, S.; Toenjes, J.; Schaefer, J.-H.; Luerick, A.; Januliene, D.; Apelt, S.; Di Iorio, D.; Wegner, S. V.; Loose, M.; Moeller, A.; Kuemmel, D.
10.1101/2025.03.27.645700 — biochemistry — Posted on 2025-03-28
366 Effects of Exercise and Konjac on Lipid Metabolism and Mechanism in Obese Rats
Ruan, L.; Lv, Z.; Wang, G.; Li, S.; You, K.; Chen, M.; Liu, S.; Pu, L.; Pang, Y.; Liu, X.; Liu, S.
10.1101/2025.03.26.645401 — biochemistry — Posted on 2025-03-28
369 Deviation from Power-Law Distribution when Scaling the Distribution of Marine Plankton Folds from Genomes to Communities
Pavlovic, L.; Vernette, C.; Pigani, E.; Joigneaux, L.; Labesse, A.; Rigonato, J.; Iudicone, D.; Lescot, M.; Timsit, Y.; Jaillon, O.
10.1101/2025.03.25.645231 — genomics — Posted on 2025-03-28
370 Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Karlsson, O.; Pandiloski, N.; Adami, A.; Garza, R.; Horvath, V.; Johansson, P. A.; Johansson, J. G.; Douse, C. H.; Jakobsson, J.
10.1101/2025.03.28.645885 — molecular biology — Posted on 2025-03-28
372 Molecular anatomy of PLK1 master docking motifs
Ren, L.; Gasper, R.; Pesenti, M. E.; Janning, P.; Mueller, F.; Koerner, C.; Geue, P.; Wohlgemuth, S.; Esposito Verza, A.; Vetter, I. R.; Musacchio, A.
10.1101/2025.03.28.645803 — biochemistry — Posted on 2025-03-28
377 Near-chromosome-level genome assembly and transcriptome of the Ural owl, Strix uralensis PALLAS, 1771
Winter, S.; Meissner, R.; Grethlein, M.; Wehrenberg, G.; Kiebler, A.; Silva, A. X.; Reyes Escobar, N.; Quesada Calderon, S. M.; Suescun, A. V.; Guzman Belmar, L.; Prost, S.
10.1101/2025.03.26.645461 — genomics — Posted on 2025-03-28
380 Membrane Proteome of Phytophthora parasitica Zoospores: How Does Sensing Occur?
Lupatelli, C. A.; Seassau, A.; Magliano, M.; Kuhn, M. L.; Rey, A.; Poet, M.; Counillon, L.; Evangelisti, E.; Thomen, P.; ATTARD, A.; Noblin, X.; Galiana, E.
10.1101/2025.03.28.645888 — microbiology — Posted on 2025-03-28
381 Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice
Bishai, W.; Shee, S.; Martinez-Martinez, Y. B.; Koleske, B.; Yabaji, S. M.; Kobzik, L.; Kramnik, I.
10.1101/2025.03.28.645957 — microbiology — Posted on 2025-03-28
382 Exploring Clinical Class 1 Integrons as Valuable Targets for the Re-sensitization of Multidrug Resistant Pathogenic Bacteria Using CRISPR-Cas
Skovmand, A. B.; Paaske, N. J.; Penil-Celis, A.; Schonemann, A. E.; Hansen, L. L.; Kot, W.; Garcillan-Barcia, M. P.; Nielsen, T. K.
10.1101/2025.03.28.645910 — microbiology — Posted on 2025-03-28
383 Collective Microbial Effects Drive Toxin Bioremediation and Enable Rational Design
Yousef, M.; Lee, K. K.; Tang, J.; Charisopoulos, V.; Willett, R.; Kuehn, S.
10.1101/2025.03.28.645802 — microbiology — Posted on 2025-03-28
385 Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes
Venetz-Arenas, N.; Schulte, T.; Müller, S.; Wallden, K.; Fischer, S.; Resink, T.; Kadri, N.; Paladino, M.; Pina, N.; Radom, F.; Villemagne, D.; Bruckmaier, S.; Cornelius, A.; Hospodarsch, T.; Alici, E.; Ljunggren, H.-G.; Chambers, B. J.; Han, X.; Sun, R.; Carroni, M.; Levitsky, V.; Sandalova, T.; Walser, M.; Achour, A.
10.1101/2025.03.28.645643 — synthetic biology — Posted on 2025-03-28
388 Co-occurrence drives horizontal gene transfer among marine prokaryotes
Douglas, G. M.; Tromas, N.; Gaudin, M.; Lypaczewski, P.; Bobay, L.-M.; Shapiro, B. J.; Chaffron, S.
10.1101/2025.03.25.645238 — evolutionary biology — Posted on 2025-03-28
389 Serine Recombinase PinR Inverts Cryptic Prophage DNA to Block Adsorption of Phages
Kirigo, J.; Huelgas Mendez, D.; Benedik, M. J.; Garcia Contreras, R.; Wood, T. K.
10.1101/2025.03.28.646004 — molecular biology — Posted on 2025-03-28
391 Inhibition of interferon signalling improves rabbit calicivirus replication in biliary organoid cultures
Smertina, E.; Pavy, M.; Peng, N.; Fahri, O.; Jenckel, M.; Strive, T.; Frese, M.; Smith, I.
10.1101/2025.03.28.645886 — microbiology — Posted on 2025-03-28
393 High-throughput Activity Reprogramming of Proteases (HARP)
Martinusen, S. G.; Slaton, E. W.; Ajayebi, S.; Pulgar, M. A.; Simas, C. F.; Nelson, S. E.; Dutta, A.; Besu, J.; Bruner, S. D.; Denard, C. A.
10.1101/2025.03.27.640893 — synthetic biology — Posted on 2025-03-28
395 Myeloid FtH Regulates Macrophage Response to Kidney Injury by Modulating Snca and Ferroptosis
Chatterjee, T.; Machado, S.; Cowen, K.; Miller, M.; Zhang, Y.; Volpicelli-Daley, L.; Fielding, L.; Pattanayak, R. P.; Rosenblum, F.; Potor, L.; Balla, G.; Balla, J.; Faul, C.; Zarjou, A.
10.1101/2025.03.25.645219 — pathology — Posted on 2025-03-28
403 The evolution of gene expression in seasonal environments
Kudo, S. N.; Ikezaki, Y.; Kusumi, J.; Hirakawa, H.; Isobe, S.; Satake, A.
10.1101/2025.03.25.645377 — evolutionary biology — Posted on 2025-03-28
405 Working memory readout varies with frontal theta rhythms
Han, H.-B.; Brincat, S. L.; Buschman, T. J.; Miller, E. K.
10.1101/2025.03.27.645781 — neuroscience — Posted on 2025-03-28
406 On variability in local field potentials
Parto-Dezfouli, M.; Johnson, E. L.; Psarou, E.; Bosman, C. A.; Krishna, B. S.; Fries, P.
10.1101/2025.03.27.645661 — neuroscience — Posted on 2025-03-28
407 Acid-Sensing Ion Channel 1a Deficiency Drives Endocrine Hypertension in Male Mice
Garcia, S. M.; Tuineau, M. N.; DeLeon, X. A.; Detweiler, N. D.; Tamang, S.; Kanagy, N. L.; Gonzalez Bosc, L. V.; Resta, T. C.; Naik, J. S.; Jernigan, N. L.
10.1101/2025.03.25.645371 — physiology — Posted on 2025-03-28
408 Shear stress targeted delivery of nitroglycerin to brain collaterals improves ischaemic stroke outcome
Litman, M.; Azarpeykan, S.; Hood, R. J.; Martin, K.; Pepperall, D.; Omileke, D.; Uzun, O.; Bhatta, D.; Yong, Y. K.; Chan, A.; Hough, N.; Johnson, S.; Bermejo, P. G.; Miteff, F.; Esperon, C. G.; Couch, Y.; Buchan, A. M.; Spratt, N. J.; Korin, N.; Ingber, D. E.; Beard, D. J.
10.1101/2025.03.25.644833 — physiology — Posted on 2025-03-28
412 Dissecting the steps in early Simian Immunodeficiency Virus dissemination following mucosal and intravenous infection of rhesus macaques
Docken, S. S.; Macairan, A.; Schlub, T. E.; Fennessey, C. M.; Varco-Merth, B.; Picker, L. J.; Okoye, A. A.; Immonen, T. T.; Cromer, D.; Keele, B. F.; Davenport, M. P.
10.1101/2025.03.24.644849 — bioinformatics — Posted on 2025-03-28
413 Termites became the dominant decomposers of the tropics after two diversification pulses
Hellemans, S.; Wang, M.; Jouault, C.; Rocha, M. M.; Battilana, J.; Carrijo, T. F.; Legendre, F.; Condamine, F. L.; Roisin, Y.; Cancello, E. M.; Scheffrahn, R. H.; Bourguignon, T.
10.1101/2025.03.25.645184 — evolutionary biology — Posted on 2025-03-28
421 Label-free Machine Learning Prediction of Chemotherapy on Tumor Spheroids using a Microfluidics Droplet Platform
Parent, C.; Horari, H.; Tocci, T.; Simon, F.; Zaidi, S.; Jan, A.; Aubert, V.; Delattre, O.; Isambert, H.; Wilhelm, C.; Viovy, J.-L.
10.1101/2025.03.25.645032 — bioengineering — Posted on 2025-03-28
423 A cortical circuit for orchestrating oromanual food manipulation
An, X.; Li, Y.; Matho, K. S.; Mohan, H.; Xu, X. H.; Whishaw, I.; Kepecs, A.; Huang, Z. J.
10.1101/2022.12.03.518964 — neuroscience — Posted on 2025-03-28
424 Deep Integrated Network Analysis: a data-driven tool to discover and characterize disease pathways in the liver
Quin, J. E.; Urrutia Iturritza, M.; Mosquera, K. D.; Hildebrandt, F. F. A.; Barrenas, F.; Ankarklev, J.
10.1101/2025.03.17.643687 — systems biology — Posted on 2025-03-28
425 Mapping regulatory networks underlying Leishmania stage differentiation reveals an essential role for protein degradation in parasite development
Pescher, P.; Douche, T.; Giai Gianetto, Q.; Druart, K.; Kovarova, J.; Li, B.; Proux, C.; Legendre, R.; Varet, H.; Rajan, K. S.; Piel, L.; Besse, C.; Boland, A.; Deleuze, J.-F.; Matondo, M.; Barrett, M. P.; Michaeli, S.; Späth, G. F.
10.1101/2025.03.24.644963 — systems biology — Posted on 2025-03-28
426 Genetically-Encoded Fluorescence Barcodes Allow for Single-Cell Analysis via Spectral Flow Cytometry
Lu, X.; Pritko, D. J.; Abravanel, M. E.; Huggins, J. R.; Ogunleye, F.; Biswas, T.; Ashy, K. C.; Woods, S. K.; Livingston, M. W.; Blenner, M.; Birtwistle, M. R.
10.1101/2024.10.23.619855 — synthetic biology — Posted on 2025-03-28
427 Ribosome biogenesis is a therapeutic vulnerability in paediatric neuroblastoma
Jouines, C.; Lo Monaco, P.; Gaucherot, A.; Monet, M.-A.; Iacono, I. D.; Simioni, V.; Monchiet, D.; Diaz, J.-J.; Combaret, V.; Marcel, V.; CATEZ, F.
10.1101/2025.03.26.645392 — cancer biology — Posted on 2025-03-28
428 SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistance
Daley, J. D.; Mukherjee, E.; Ferraro, D.; Bhaskar, S.; Green, A.; Meyer, E. M.; Tawbi, H.; Burgess, M.; Bruno, T.; Cillo, A. R.; Bailey, K. M.
10.1101/2025.03.26.645492 — cancer biology — Posted on 2025-03-28
431 Sub-second Fluctuation between Top-Down and Bottom-Up Modes Distinguishes Diverse Human Brain States
Park, Y.; Cha, Y.; Kim, H.; Kim, Y.; Woo, J. H.; Cho, H.; Mashour, G. A.; Xu, T.; Lee, U.; Hong, S.-J.; Honey, C.; Moon, J.-Y.
10.1101/2025.03.12.642768 — neuroscience — Posted on 2025-03-28
432 Selective direct motor cortical influence during naturalistic climbing in mice
Koh, N.; Ma, Z.; Sarup, A.; Kristl, A. C.; Agrios, M.; Young, M.; Miri, A.
10.1101/2023.06.18.545509 — neuroscience — Posted on 2025-03-28
433 Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescence
Hu, J.; Zhang, B.; Chen, J.; Huang, G.; Zhou, H.; Yang, F.; Liu, K.; Zheng, S.; Liu, X.; Liu, J.; Hu, H.; Wang, L.; Zhang, J.; Dai, L.; Chen, Q.; Pan, X.; Li, H.; Yu, H.; HONG, X.
10.1101/2025.03.26.645381 — cancer biology — Posted on 2025-03-28
434 ALK Inhibition Prolongs Survival in a Mouse Model of ALK-positive Anaplastic Thyroid Cancer
Machlah, Y. M.; Brandenburg, T.; Hones, G. S.; Theurer, S.; Prinz, A. D.; Hoppe, C.; Cansiz, F.; Siveke, J. T.; Schulte, J. H.; Undeutsch, H.; Kero, J.; Koster, J.; Fuhrer, D.; Moeller, L. C.
10.1101/2025.03.25.642535 — cancer biology — Posted on 2025-03-28
440 Formation of Task Representations and Replay in Mouse Medial Prefrontal Cortex
Shabani, H.; Muysers, H.; Yiu, Y.-H.; Sauer, J.-F.; Bartos, M.; Leibold, C.
10.1101/2025.03.07.642001 — neuroscience — Posted on 2025-03-28
441 Mapping the Psychosis Spectrum -- Imaging Neurosubtypes from Multi-Scale Functional Network Connectivity
Ballem, R.; Camazon, P. A.; Jensen, K. M.; Bajracharya, P.; Diaz-Caneja, C. M.; Bustillo, J. R.; Turner, J. A.; Fu, Z.; Chen, J.; Calhoun, V.; Iraji, A.
10.1101/2025.02.11.637551 — neuroscience — Posted on 2025-03-28
453 Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis
Lin, Z.; Wang, W.; Liu, D.; Liu, Q.; Wang, C.; Xu, Z.; Wu, Z.; Zhou, X.; Zhang, X.; Huang, Y.; Zhao, Q.; Yang, J.
10.1101/2024.04.20.590432 — microbiology — Posted on 2025-03-28
454 A Phenotype-Driven Multi-Omic Atlas of Glioblastoma Invasion
Krona, C.; Sundstrom, A.; Rosen, E.; Kundu, S.; Mangukiya, H. B.; Babacic, H.; Uppman, I.; Skeppas, M.; Larsson, I.; Elfineh, L.; Cao, X.; Ramachandra, R.; Elgendy, R.; Dave, Z.; Doroszko, M.; Olausson, K. H.; Wikstrom, J.; Pernemalm, M.; Nelander, S.
10.1101/2025.03.25.645260 — cancer biology — Posted on 2025-03-28
456 Conserved strategies underpin the replicated evolution of aridity tolerance in trees
Halliwell, B.; Blackman, C. J.; Gallagher, R. V.; Yates, L. A.; Britton, T. G.; Jones, R. C.; Nicolle, D.; Hartill, G. E.; Wright, I. J.; Holland, B. R.; Brodribb, T. J.
10.1101/2025.03.06.641812 — evolutionary biology — Posted on 2025-03-28
457 Single Nucleus Profiling Highlights the All-Brain Echinoderm Nervous System
Paganos, P.; Ullrich-Lüter, J.; Almazan, A.; Voronov, D.; Carl, J.; Zakrzewski, A. C.; Zemann, B.; Rusciano, M. L.; Sancerni, T.; Schauer, M.; Akar, O.; Caccavale, F.; Cocurullo, M.; Benvenuto, G.; Croce, J. C.; Lüter, C.; Arnone, M. I.
10.1101/2025.03.24.644250 — evolutionary biology — Posted on 2025-03-28
459 Changing food conditions and size declines in a North Sea forage fish
Olin, A. B.; Banas, N. S.; Heath, M. R.; Wright, P. J.; MacDonald, A.; Wanless, S.; Daunt, F.; Speakman, J. R.; Nager, R. G.
10.1101/2025.03.25.643521 — ecology — Posted on 2025-03-28
462 Gut microbiome variation in juvenile blue tits in a European urban mosaic.
Fus, L.; Jünemann, S.; Di Lecce, I.; Sudyka, J.; Szulkin, M.; Maraci, O.
10.1101/2025.03.26.643606 — ecology — Posted on 2025-03-28
464 Acoustic indices predict recovery of tropical bird communities for taxonomic and functional composition
Kuemmet, S.; Mueller, J.; Burivalova, Z.; Schaefer, H. M.; Gelis, R.; Freile, J.; Busse, A.; Puels, M.; Kriegel, P.; Seibold, S.; Bluethgen, N.; de la Hoz, M.; Schleuning, M.; Neuschulz, E. L.; Mitesser, O.; Kortmann, M.
10.1101/2025.03.25.645239 — ecology — Posted on 2025-03-28
467 The Golgi Rim is a Precise Tetraplex of Golgin Proteins that Can Self-Assemble into Filamentous Bands
Su, M.; Radhakrishnan, A.; Yan, Y.; Tian, Y.; Zheng, H.; M'Saad, O.; Graham, M.; Coleman, J.; Goder, J. N. D.; Liu, X.; Zhang, Y.; Bewersdorf, J.; Rothman, J. E.
10.1101/2025.03.27.645134 — cell biology — Posted on 2025-03-28
468 Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens
Aguado-Alvaro, L. P.; Garitano, N.; Esser-Skala, W.; Sayers, J.; del Valle, C.; Alameda, D.; Mendieta, J.; Calleja-Cervantes, M. E.; Goni-Salaverria, A.; Zazpe, J.; de Vito, A. R.; Marchese, F.; Alignani, D.; Cudini, J.; Gross, T.; Rabago, G.; Narayan, N.; Martinez, L.; Martinez, S.; Huntly, B.; Ridley, P.; Gonzalez-Miqueo, A.; Taylor-King, J. P.; Fortelny, N.; Pelacho, B.; Lara-Astiaso, D.
10.1101/2025.03.28.645873 — cell biology — Posted on 2025-03-28
469 T-World: A highly general computational model of a human ventricular myocyte
Tomek, J.; Zhou, X.; Martinez-Navarro, H.; Holmes, M.; Bury, T.; Arantes Berg, L.; Tomkova, M.; Jo, E.; Nagy, N.; Bertrand, A.; Bueno-Orovio, A.; Colman, M. A.; Rodriguez, B.; Bers, D. M.; Heijman, J.
10.1101/2025.03.24.645031 — cell biology — Posted on 2025-03-28
471 RNA-Associated Glycoconjugates Highlight Potential Ambiguities in glycoRNA Analysis
Kim, S.; Choi, Y.-g.; Janssen, K.; Langenbach, J.-W. H.; van den Brink, D. J.; Bull, C.; Joshi, B. S.; Pomorski, A.; Raz, V.; Tanenbaum, M. E.; Miesen, P.; Li, Z.; Joo, C.
10.1101/2024.03.12.584655 — molecular biology — Posted on 2025-03-28
472 Statistical end-to-end analysis of large-scale microbial growth data with DGrowthR
Feldl, M.; Olayo-Alarcon, R.; Amstalden, M. K.; Zannoni, A.; Peschel, S.; Sharma, C. M.; Brochado, A. R.; Müller, C. L.
10.1101/2025.03.25.645164 — microbiology — Posted on 2025-03-28
478 Functional landscape of circular RNAs in human cancer cells
Her, P. H.; Li, T.; Huang, Z.; Xu, X.; Yang, W.; Chen, M.; Teng, M.; Chen, S.; Zeng, Y.; Liu, S.; Haibe-Kains, B.; Soares, F.; Ming, J.; He, H.
10.1101/2025.03.24.645016 — cancer biology — Posted on 2025-03-28
481 Accelerated maturation of branched organoids confined in collagen droplets
Ruider, I.; Pastucha, A.; Raich, M. K.; Xu, W.; Liu, Y.; Reichert, M.; Weitz, D.; Bausch, A.
10.1101/2025.03.24.644794 — bioengineering — Posted on 2025-03-28
482 Lipids modulate the organization of VDAC1, the gatekeeper of mitochondria
Lafargue, E.; Duneau, J.-P.; Buzhinsky, N.; Ornelas, P.; Ortega, A.; Ravishankar, V.; Sturgis, J. N.; Casuso, I.; Bergdoll, l.
10.1101/2024.06.26.597124 — biochemistry — Posted on 2025-03-28
483 Food-web coupling by mobile consumers has individual to ecosystem level effects
Peller, T.; Chaouat, L.; Broadbent, H.; Giacomuzzo, E.; Kaeser, S.; Mueller, G.; Altermatt, F.
10.1101/2025.03.25.645357 — ecology — Posted on 2025-03-28
484 A systematic review of climate-change driven range shifts in mosquito vectors
Lyberger, K.; Robinson, A. R.; Couper, L.; Delwel, I.; Glidden, C.; Qian, C.; Burslem, A.; Fernandez, F.; Gao, B.; Garcia, G.; Gomez, J.; Griffin, C.; Jackson, S.; King, A.; Manes, O.; Song, A.; Tran, E.; Mordecai, E. A.
10.1101/2025.03.25.645279 — ecology — Posted on 2025-03-28
485 Perception of Mangrove Ecosystem Conservation: A Case of Silvofishery in East Kalimantan, Indonesia
Anggoro, A. W.; Octifanny, Y.; Norvyani, D. A.; Adharina, N. D.; Ilman, M.; Hidayat, T.; Nirwan, M.; Basir, B.; Adriano, V.; Muis, R.; Al Malik, M. D.; Trisnawati, A.
10.1101/2025.03.25.645347 — ecology — Posted on 2025-03-28
486 Ecological plasticity explains the distribution of sympatric and allopatric mouse lemurs (Microcebus spp.) in northeastern Madagascar
Schuessler, D.; van Elst, T.; Rabemananjara, N. R.; Radriarimanga, T.; Rafamantanantsoa, S. M.; Randimbiharinirina, R. D.; Rasolondraibe, E.; Mantilla-Contreras, J.; Radespiel, U.
10.1101/2025.03.24.645043 — ecology — Posted on 2025-03-28
489 Climate-driven increase in transmission of wildlife malaria parasite over the last quarter century
Theodosopoulos, A. N.; Andreasson, F.; Jönsson, J.; Nilsson, J.; Nord, A.; Raberg, L.; Stjernman, M.; Lara, A. S. T.; Nilsson, J.-A.; Hellgren, O.
10.1101/2025.03.25.644544 — ecology — Posted on 2025-03-28
490 Can the marginal male hypothesis explain spatial density variation in pinnipeds?
van Benthem, K. J.; Nagel, R.; Beckmann, L. M.; Hoffman, J. I.; Wittmann, M. J.
10.1101/2025.03.24.644795 — ecology — Posted on 2025-03-28
491 Infection and host-feeding patterns of West Nile virus vectors varies by urban greenspace composition
Mackay, A. J.; Yan, J.; Kim, C.-H.; Cara, C.; Chesser, L.; Alfaro, E.; Avara, M.; Ward, M.; Magle, S.; Murray, M. H.; Stone, C.
10.1101/2025.03.24.645034 — ecology — Posted on 2025-03-28
492 Revealing the organization of species stability in ecological communities
Lajaaiti, I.; Kefi, S.; Loreau, M.; Ardichvili, A.; Arnoldi, J.-F.
10.1101/2025.03.25.645234 — ecology — Posted on 2025-03-28
495 Reactive Oxygen Species Counteract Wound Contraction and Promote Wound Healing
Ding, C.; Li, L.; Wang, Y.; Nguyen, H.-A. A.; Zhang, W.; Chan, D.; Umulis, D. M.; Staiger, C. J.; Tepole, A. B.; Deng, Q.
10.1101/2025.03.27.645726 — cell biology — Posted on 2025-03-28
496 In vivo self-renewal and expansion of quiescent stem cells from a non-human primate
Kang, J.; Kanugovi, A.; Stella, P.; Frimand, Z.; Farup, J.; Urtasun, A.; Liu, S.; Clausen, A.-S.; Ishak, H.; Bui, S.; Kim, S.; Ezran, C. S.; Botvinnik, O.; Porpiglia, E.; Krasnow, M. A.; de Morree, A.; Rando, T.
10.1101/2025.03.27.645793 — cell biology — Posted on 2025-03-28
497 Quantitative AI-based DNA fiber workflow to study replication stress
Fagherazzi, P.; Diekmann, T.; Ardizzoia, A.; Machacova, Z.; Negi, S.; Yadav, A. K.; Moudry, P.; Costanzo, V.; Polasek-Sedlackova, H.
10.1101/2025.03.27.645743 — cell biology — Posted on 2025-03-28
498 Breaking Through Microbial Defences - Organic Acid-Based Deep Eutectic Solvents as a Neoteric Strategy in Bacterial Biofilm, Persister, and Fungal Control
Swebocki, T.; Cieminska, K.; Bortolus, C.; Muchembled, J.; Mechouche, M. S.; Jacquin, J.; Boukherroub, R.; Haddadi, K.; Siah, A.; Sendid, B.; Kocot, A.; Plotka, M. A.
10.1101/2025.03.25.645211 — microbiology — Posted on 2025-03-28
499 In vitro selection of cyclized, glycosylated peptide antigens that tightly bind HIV high mannose patch antibodies
Bailey, J. K.; Horiya, S.; Neralkar, M.; Horvath, V.; Nakamoto, K.; Temme, J. S.; Turra, R. J.; Krauss, I. J.
10.1101/2025.03.24.645033 — immunology — Posted on 2025-03-28
501 Structure-activity relationships of coumarin and its analogs and mechanistic insights into germination inhibition by coumarin
Fukuda, K.; Hyakutake, S.; Oishi, T.; Yoshida, M.; Koga, M.; Egami, C.; Matsura, H.; Ito, R.; Tsukahara, K.; Noda, M.; Tomonaga, K.; Chifu, K.; Ichimaru, R.; Fujito, E.; Mori, K.; Tokuyama, Y.; Yoshida, T.; Ryuda, N.; Nagano, Y.; Matsutaka, K.
10.1101/2024.05.23.595645 — plant biology — Posted on 2025-03-28
505 Recruitment, rewiring, and deep conservation in flowering plant gene regulation
Baumgart, L. A.; Greenblum, S. I.; Morales-Cruz, A.; Wang, P.; Zhang, Y.; Yang, L.; Chen, C.; Dilworth, D. J.; Garretson, A. C.; Grosjean, N.; He, G.; Savage, E.; Yoshinaga, Y.; Blaby, I. K.; Daum, C. G.; O'Malley, R. C.
10.1101/2024.10.08.617089 — genomics — Posted on 2025-03-28
508 Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits
Koh, M.; Anselmi, F.; Kaushalya, S. K.; Hernandez, D. E.; Bast, W. G.; Villar, P. S.; Chae, H.; Davis, M. B.; Teja, S. S.; Qu, Z.; Gradinaru, V.; Gupta, P.; Banerjee, A.; Albeanu, D. F.
10.1101/2025.02.24.639992 — neuroscience — Posted on 2025-03-28
509 Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling
Tetenborg, S.; Shihabeddin, E.; Kumar, E. O. A. M.; Sigulinsky, C.; Dedek, K.; Lin, Y.-P.; Echeverry, F.; Hoff, H.; Pereda, A.; Jones, B. W.; Ribelayga, C.; Ebnet, K.; Matsuura, K.; O'Brien, J.
10.1101/2024.11.26.625481 — neuroscience — Posted on 2025-03-28
511 A gnotobiotic system reveals multifunctional effector roles in plant-fungal pathogen dynamics
Punt, W.; Park, J.; Rovenich, H.; Kraege, A.; Schmitz, N.; Wieneke, J.; Snelders, N.; Fiorin, G. L.; Lopez-Moral, A.; Chavarro, E.; Petti, G.; Wippel, K.; Thomma, B.
10.1101/2025.03.27.645772 — plant biology — Posted on 2025-03-28
512 Biosynthesis and Physiological Significance of Organ-Specific Flavonol Glycosides in Solanaceae
Shin, D.; Zhao, H.; Tucker, E.; Cho, K. H.; Liu, D.; Wang, Z.; Latimer, S.; Basset, G.; Wang, Y.; Ding, Y.; Kim, J.
10.1101/2025.03.27.645607 — plant biology — Posted on 2025-03-28
514 Microbiome responses to natural Fusarium infection in field-grown soybean plants
van Bentum, S.; O'Banion, B. S.; Gates, A. D.; van Pelt, H. A.; Bakker, P. A. H. M.; Pieterse, C. M. J.; Lebeis, S. L.; Berendsen, R. L.
10.1101/2025.03.27.645697 — plant biology — Posted on 2025-03-28
516 Floral nectar microbiota of Persea americana inhibits pathogens and improves plant fitness
Lopez-Garcia, M.; Rodriguez-Gomez, I. A.; Perez-Bautista, Y.; Villanueva-Espino, L. A.; Molina-Torres, M.; Patino-Conde, V.; Ruiz-Gizar, L. E.; Garcia-Melendez, M.; Hernandez-Cristobal, O.; Llanderal-Mendoza, J.; Quesada-Avendano, M.; Reverchon, F.; Oyama, K.; Mendez-Bravo, A.
10.1101/2025.03.27.645287 — plant biology — Posted on 2025-03-28
517 Molecular mechanisms underlying the determination of axillary bud fate and outgrowth into branch crown in strawberry
Alonso, M.; Prevost, P.; Potier, A.; Martin, P. G.; Caraglio, Y.; Nicolas, M.; Hernould, M.; Rothan, C.; Denoyes, B.; Gaston, A.
10.1101/2025.03.27.645709 — plant biology — Posted on 2025-03-28
519 NF-κB Epigenetic Attractor Landscape Drives Breast Cancer Heterogeneity
Lopes, F. J. P.; Pires, B. R. B.; Lima, A. A. B.; Binato, R.; Abdelhay, E.
10.1101/2024.07.10.602798 — cancer biology — Posted on 2025-03-28
521 Cell Function Graphics: TOGGLE delineates fate and function within individual cell types via single-cell transcriptomics
Chen, J.; Chen, Z.; Sun, T.; Jiang, E.; Liu, K.; Nong, Y.; Yuan, T.; Dai, C. C.; Yan, Y.; Ge, J.; Wu, H.; Yang, T.; Wang, S.; Su, Z.; Song, T.; Abdelbsset-Ismail, A.; Li, Y.; Li, C.; Singhal, R. A.; Yang, K.; Cai, L.; Carll, A. P.
10.1101/2025.01.01.631041 — bioinformatics — Posted on 2025-03-28
523 Secretory leukocyte protease inhibitor influences periarticular joint inflammation in B. burgdorferi-infected mice
Yu, Q.; Tang, X.; Hart, T.; Homer, R.; Belperron, A. A.; Bockenstedt, L.; Ring, A.; Nakamura, A.; Fikrig, E.
10.1101/2024.11.24.625079 — microbiology — Posted on 2025-03-28
525 Comparative performance of novel viral landscape phylogeography approaches
Dellicour, S.; Gambaro, F.; Jacquot, M.; Lequime, S.; Baele, G.; Gilbert, M.; Pybus, O. G.; Suchard, M. A.; Lemey, P.
10.1101/2025.03.24.645003 — evolutionary biology — Posted on 2025-03-27
526 METTL1/WDR4-mediated m7G Hypermethylation of SCLT1 mRNA Promotes Gefitinib Resistance in Non-small Cell Lung Cancer
Zhou, S.; Wang, Y.; Wei, J.; An, K.; Shi, Y.; Zhang, X.; Wang, H.; Feng, L.; He, L.; Zhang, Y.; Ren, T.; Li, O.; Yang, Y.-G.; Kan, Q.; Tian, X.
10.1101/2025.03.26.645570 — molecular biology — Posted on 2025-03-27
531 Comparative susceptibility of Old World and New World bat cell lines to Zika virus: Insights into viral replication and inflammatory responses
Brown, A. J.; Fagre, A. C.; Gilson, J.; Horton, J.; Rivero, R.; Karimi, M.; Speranza, E.; Letko, M. C.; Seifert, S. N.
10.1101/2025.03.27.645813 — microbiology — Posted on 2025-03-27
532 Analysis of human colostrum reveals differential co-occurrence networks of metabolites, microbiota, and cytokines in maternal obesity
Gamez-Valdez, J. S.; Corona-Cervantes, K.; Sanchez-Salguero, E. S.; Alcorta-Garcia, M. R.; Lopez-Villasenor, C. N.; Carballo-Castaneda, R. A.; Moreno-Ulloa, A.; Lara-Diaz, V. J.; Brunck, M. E. G.; Licona-Cassani, C.
10.1101/2025.03.27.645789 — microbiology — Posted on 2025-03-27
535 Protease mimicry: dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins
Yosaatmadja, Y.; Ung, V.; Liu, X.; Zhao, Y.; Wardega, J. K.; Shetty, A.; Schoensee, S.; Leung, I. K. H.; Keown, J. R.; Goldstone, D. C.; Baker, E. N.; Young, P. G.; Mercadante, D.; Squire, C. J.
10.1101/2025.03.26.645365 — biochemistry — Posted on 2025-03-27
536 Comprehensive Evaluation of Diverse Massively Parallel Reporter Assays to Functionally Characterize Human Enhancers Genome-wide
Zhang, J.; Leung, A. K.-Y.; Zhu, Y.; Yao, L.; Willis, A.; Pan, X.; Ozer, A.; Zhou, Z.; Silklenka, K.; Berrera, A.; Liang, J.; Tippens, N. D.; Reddy, T. E.; Lis, J. T.; Yu, H.
10.1101/2025.03.25.645321 — genomics — Posted on 2025-03-27
538 Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites
Garcia-Reyes, S.; Rusniok, C.; Robert-Genthon, M.; Faudry, E.; Gomez-Valero, L.; Chenal-Francisque, V.; Guyon, L.; Caspar, Y.; Chavez, G. S.; Buchrieser, C.; ATTREE, I.
10.1101/2025.03.27.645720 — microbiology — Posted on 2025-03-27
549 Fighting Aspergillus infection using biocontrol bacteria: A proof-of-concept of environmental interference in a translational setting
Palmieri, F.; Trompette, A.; Shanmuganathan, A.; Bouchard, A.; Pernot, J.; Junier, T.; Kelliher, J. M.; Chain, P.; Harris, J. F.; VALLAT-MICHEL, A. J.; Pagni, M.; Von Garnier, C.; Stucki, J.; Hobi, N.; Koutsokera, A.; Neuenschwander, S.; Ubags, N.; Junier, P.
10.1101/2025.03.27.645790 — microbiology — Posted on 2025-03-27
550 Characterization of two non-competing antibodies to influenza H3N2 hemagglutinin stem reveals its evolving antigenicity
Gopal, A. B.; Lv, H.; Pholcharee, T.; Ouyang, W. O.; Teo, Q. W.; Luo, Y.; Tang, Y. S.; Luo, M.; Mok, C. K. P.; Wu, N. C.
10.1101/2025.03.24.644842 — immunology — Posted on 2025-03-27
553 Establishment of an efficient one-step enzymatic synthesis of cyclic-2,3-diphosphoglycerate
Stracke, C.; Meyer, B. H.; DeRose, S. A.; Ferrandi, E. E.; Kublanov, I.; Isupov, M. N.; Harmer, N.; Monti, D.; Littlechild, J.; Mueller, F.; Snoep, J. L.; Braesen, C.; Siebers, B.
10.1101/2025.02.21.639460 — bioengineering — Posted on 2025-03-27
554 Proton-secreting cells modulate mucosal immune surveillance in the male reproductive tract
Da Silva, A.; Barrachina, F.; Avenatti, M. C.; Elizagaray, M. L.; Bastepe, I.; Sasso-Cerri, E.; Battistone, M. A.
10.1101/2025.03.26.645301 — developmental biology — Posted on 2025-03-27
555 Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
Zhang, C.; Diaz-Hernandez, M. E.; Fukunaga, T.; Shenoy, S.; Yoon, S. T.; Haglund, L.; Drissi, H.
10.1101/2024.10.11.617862 — cell biology — Posted on 2025-03-27
556 Non-Homogeneous Distribution of Inhibitory Inputs Among Motor Units in Response to Nociceptive Stimulation
Hug, F.; Dernoncourt, F.; Avrillon, S.; Thorstensen, J.; Besomi, M.; van den Hoorn, W.; Tucker, K.
10.1101/2024.10.05.616762 — neuroscience — Posted on 2025-03-27
561 Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats
Tonnele, H.; Chen, D.; Morillo, F.; Garcia-Calleja, J.; Chitre, A. S.; Johnson, B. B.; Sanches, T. M.; Bonder, M. J.; Gonzalez, A.; Kosciolek, T.; George, A. M.; Han, W.; Holl, K.; Horvath, A.; Ishiwari, K.; King, C. P.; Lamparelli, A. C.; Martin, C. D.; Martinez, A. G.; Netzley, A. H.; Tripi, J. A.; Wang, T.; Bosch, E.; Doris, P. A.; Stegle, O.; Chen, H.; Flagel, S. B.; Meyer, P. J.; Richards, J. B.; Robinson, T. E.; Woods, L. C. S.; Polesskaya, O.; Knight, R.; Palmer, A. A.; Baud, A.
10.1101/2025.03.20.644349 — genetics — Posted on 2025-03-27
562 The spatiotemporal distribution of human pathogens in ancient Eurasia and the emergence of zoonotic diseases
Sikora, M.; Canteri, E.; Fernandez-Guerra, A.; Oskolkov, N.; Agren, R.; Hansson, L.; Irving-Pease, E. K.; Muehlemann, B.; Holtsmark Nielsen, S.; Scorrano, G.; Allentoft, M. E.; Seersholm, F. V.; Schroeder, H.; Gaunitz, C.; Stenderup, J.; Vinner, L.; Jones, T. C.; Nystedt, B.; Sjoegren, K.-G.; Parkhill, J.; Fugger, L.; Racimo, F.; Kristiansen, K.; Iversen, A. K. N.; Willerslev, E.
10.1101/2023.10.06.561165 — evolutionary biology — Posted on 2025-03-27
564 Combined evidence reveals the origin of a rapid range expansion despite retained genetic diversity and a weak founder effect
Bergman, N. M.; Lehikoinen, P.; Kluen, E.; Bensch, S.; Lo Cascio Saetre, C.; Eroukhmanoff, F.; Fossoy, F.; Prochazka, P.; Smith, W. J.; Stokke, B. G.; Primmer, C. R.; Thorogood, R.; Ronka, K.
10.1101/2025.01.06.631438 — evolutionary biology — Posted on 2025-03-27
566 Towards Clinical-Grade Bioengineered Airways: A Study on Stem Cell Renewal and Epithelial Differentiation
Adamo, D.; Genna, V. G.; Galaverni, G.; Chiavelli, C.; Merra, A.; Lepore, F.; Boraldi, F.; Quaglino, D.; Evangelista, J.; Lococo, F.; Pellegrini, G.
10.1101/2023.12.28.573530 — cell biology — Posted on 2025-03-27
567 FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice
Duque-Wilckens, N.; Joseph, D.; Syed, M.; Smith, B.; Maradiaga, N.; Yeh, S.-Y.; Srinivasan, V.; Sotomayor, F.; Durga, K.; Nestler, E. J.; Moeser, A.; Robison, A. J.
10.1101/2024.05.06.592755 — immunology — Posted on 2025-03-27
568 Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep
Meijer, E. J.; Mueller, M.; Krone, L. B.; Yamagata, T.; Hoerder-Suabedissen, A.; Wilcox, S.; Alfonsa, H.; Chakrabarty, A.; Guidi, L.; Oliver, P.; Vyazovskiy, V. V.; Molnar, Z.
10.1101/2024.10.26.620399 — neuroscience — Posted on 2025-03-27
569 Is Britain still Great for Pine Marten? A Habitat Suitability Assessment
Lewis, E.; Swinnerton, K.; Fitzmaurice, A.; Armour-Chelu, N.; Gardner, R.; Ball, L.
10.1101/2025.03.19.643030 — zoology — Posted on 2025-03-27
571 Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression
Foerster, L. C.; Kaya, O.; Wust, V.; Danciu, D.-P.; Bekavac, M.; Ziegler, K. C.; Akcay, V.; Stinchcombe, N.; Tang, A.; Tang, J.; Brunken, J.; Gesteira Perez, N.; Ma, X.; Sadik, A.; Opitz, C.; Liu, H.; Wirtz, C. R.; Marciniak-Czochra, A.; Anders, S.; Goncalves, A.; Martin-Villalba, A.
10.1101/2023.09.15.557713 — cancer biology — Posted on 2025-03-27
572 Defacing biases visual quality assessments of structural MRI
Provins, c.; Savary, E.; Sanchez, T.; Mullier, E.; Barranco, J.; Fischi-Gomez, E.; Aleman-Gomez, Y.; Richiardi, J.; Poldrack, R. A.; Hagmann, P.; Esteban, O.
10.1101/2024.10.11.617777 — bioinformatics — Posted on 2025-03-27
574 Androgen receptor-mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells
Hiltunen, J.; Helminen, L.; Aaltonen, N.; Launonen, K.-M.; Laakso, H.; Malinen, M.; Niskanen, E. A.; Palvimo, J. J.; Paakinaho, V.
10.1101/2024.11.15.623719 — genomics — Posted on 2025-03-27
575 Ayurveda based phenotype annotation integrated with Expectation Maximization algorithm reveal six biological clusters of rare diseases: potential in resolving ciliopathies
Joshi, A.; Jangir, D.; Sharma, A.; Anand, T.; Verma, H.; Yadav, M.; Rangani, N.; Joshi, P.; Singh, R. P.; Kumar, S.; Girdhar, S.; Sharma, R.; Kumar, A.; Dey, L.; Mukerji, M.
10.1101/2024.09.13.612844 — genetics — Posted on 2025-03-27
580 A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses
Sid Ahmed, S.; Zimmermann, L.; Imle, A.; Wuebben, K.; Tibroni, N.; Rauch-Wirth, L.; Muench, J.; Chlanda, P.; Graw, F.; Fackler, O. T.
10.1101/2023.11.22.568261 — immunology — Posted on 2025-03-27
581 The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection
Desgraupes, S.; Perrin, S.; Gouy, B.; Decorsiere, A.; Wang, Y. E.; Palazzo, A. F.; Munier, S.; Arhel, N. J.
10.1101/2025.03.23.644734 — immunology — Posted on 2025-03-27
582 In vivo reconstruction of Duvernoy's postmortem vasculature images
Gulban, O. F.; Stirnberg, R.; Tse, D. H. Y.; Pizzuti, A.; Koiso, K.; Archila-Melendez, M. E.; Huber, R.; Bollmann, S.; Goebel, R.; Kay, K.; Ivanov, D.
10.1101/2025.03.23.644588 — neuroscience — Posted on 2025-03-27
584 Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-beta-sheet formation
Sanchez-Burgos, I.; Tejedor, A. R.; Castro, A.; Feito, A.; Collepardo-Guevara, R.; Rene Espinosa, J.
10.1101/2024.12.16.628676 — biophysics — Posted on 2025-03-27
585 The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis
Ruggiero, N.; Ciuciu, A.; Sedigh, A.; Rajpar, I.; Shelton, D.; Belanger, P.; Gropp, K.; Collins, J. A.; Freeman, T. A.; Tomlinson, R. E.
10.1101/2025.03.24.645018 — bioengineering — Posted on 2025-03-27
586 The Human Metabolome and Machine Learning Improves Predictions of the Post-Mortem Interval
Magnusson, R.; Söderberg, C.; Ward, L. J.; Arpe, J.; Kugelberg, F. C.; Elmsjö, A.; Green, H.; Nyman, E.
10.1101/2025.03.24.644974 — systems biology — Posted on 2025-03-27
589 Odorant representations indicate nonlinear processing across the olfactory system
Olivares, J.; Orio, P.; Sadilek, V.; Schmachtenberg, O.; Canales-Johnson, A.
10.1101/2022.04.15.488302 — neuroscience — Posted on 2025-03-27
590 Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions
Sattin, A.; Nardin, C.; Daste, S.; Moroni, M.; Reddy, I.; Liberale, C.; Panzeri, S.; Fleischmann, A.; Fellin, T.
10.1101/2024.07.24.604890 — neuroscience — Posted on 2025-03-27
593 SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling
Anielska-Mazur, A.; Rachowka, J.; Polkowska-Kowalczyk, L.; Krzyszton, M.; Cieslak, D.; Mazur, R.; Bucholc, M.; Rakowska, J.; Trzmiel, D.; Stachula, P.; Olechowski, M.; Swiezewski, S.; Dobrowolska, G.; Kulik, A.
10.1101/2025.03.25.645185 — plant biology — Posted on 2025-03-27
594 Omics-driven Identification of Candidate Genes and SNP markers in a Major QTL Controlling Early Heading in Rice
Rao, D.; T, N. S.; CG, G.; Gaur, N.; Jamaloddin, M.; Maganti, S. M.; Raman, M. S.; Patel, H. K.; Tiwari, S.; Sonti, R. V.
10.1101/2025.03.25.645207 — plant biology — Posted on 2025-03-27
596 AIPAMPDS: an AI platform for antimicrobial peptide design and screening
Pian, C.; Huang, J.; Yang, Y.; Li, Y.; Gao, L.; Zhao, W.; Wang, Z.; Xu, X.; Ji, J.; Zhang, Y.; Liu, Y.; Zhang, L.
10.1101/2025.03.24.644774 — bioinformatics — Posted on 2025-03-27
602 Root exudation facilitate water infiltration and rewetting of dry soil
Gomez, E.; Mair, A.; Martin, I.; de las Heras, G.; Ptashnyk, M.; Dupuy, L. X.
10.1101/2025.03.26.645447 — plant biology — Posted on 2025-03-27
603 Rpv2 is part of a cluster of NLRs specific to Vitis rotundifolia and confers extreme resistance to grapevine downy mildew.
Marsan, L.; Prado, E.; Wiedemann-Merdinoglu, S.; Schmidlin, L.; Blanc, S.; Delame, M.; Schnee, S.; Arti, B.; Barnabe, G.; Velt, A.; Dumas, V.; Merdinoglu, D.; Rustenholz, C.; Mestre, P.
10.1101/2025.03.25.645223 — plant biology — Posted on 2025-03-27
604 ELIP is preferentially expressed in stomatal guard cells and has a role in stomatal opening upon transition to light
Bednarczyk, D.; Cohen, M.; Kamara, I.; Tiwari, V.; Itafa, E. A.; Regon, P.; Savidor, A.; Yadav, D.; Belausov, E.; Charuvi, D.
10.1101/2025.03.26.645183 — plant biology — Posted on 2025-03-27
605 Multilevel analysis of response to plant growth promoting and pathogenic bacteria in Arabidopsis roots and the role of CYP71A27 in this response
Koprivova, A.; Ristova, D.; Berka, M.; Berkova, V.; Türksoy, G. M.; Andersen, T. G.; Westhoff, P.; Cerny, M.; Kopriva, S.
10.1101/2025.03.26.645393 — plant biology — Posted on 2025-03-27
607 A novel allele of Mitogen Activated Protein Kinase 6 is linked to disease resistance and constitutive immunity in rice.
C.G., G.; Mohammed, J.; Rao, D.; Gaur, N.; Supriyo, A. R.; Sao, N.; Niranjan, D.; Tiwari, S.; Laha, G. S.; Barbadikar, K. M.; Sundaram, R. M.; Maganti, S. M.; Patel, H. K.; Sonti, R. V.
10.1101/2025.03.25.645290 — plant biology — Posted on 2025-03-27
608 Amino acid biostimulant increases pine photosynthetic efficiency and growth through optimised mycobiome and nitrogen assimilation
Chowdhury, J.; Milne, N.; Wade, M.; Sharwood, R.; Thuaux, B.; Green, P.; Last, I. L.; Senior, J.; Carnegie, A.; Elms, S.; Plett, K. L.; Plett, J. M.
10.1101/2025.03.26.645424 — plant biology — Posted on 2025-03-27
612 Elucidating Chiral Myosin-Induced Actin Dynamics: From Single Filament Behavior to Collective Structures
Haraguchi, T.; Yoshimura, K.; Inoue, Y.; Imi, T.; Hasegawa, K.; Nagai, T.; Mori, T.; Matsuno, K.; Ito, K.
10.1101/2025.03.26.645581 — cell biology — Posted on 2025-03-27
613 Mechanosensitive interactions between Jag1 and Myo1c control Jag1 trafficking in endothelial cells
Stassen, O. M. J. A.; Virtanen, N.; Lin, K.-L.; Suarez Rodriguez, F.; Heijmans, M. J. M.; Zhao, F.; Corthals, G. L.; Bouten, C. V. C.; Sahlgren, C. M.
10.1101/2025.03.27.645426 — cell biology — Posted on 2025-03-27
614 Profilin promotes lamellipodium protrusion by tuning the antagonistic activities of CP and VASP
Tang, Y.; Schaks, M.; Mietkowska, M.; Scholz, J.; Benavente-Naranjo, R.; Korber, S.; Li, Z.; Lambert, C.; Stradal, T. E. B.; Karlsson, R.; Bieling, P.; Faix, J.; Falcke, M.; Rottner, K.
10.1101/2025.03.26.645585 — cell biology — Posted on 2025-03-27
615 Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease
Ly, J.; Tao, Y. F.; Di Bernardo, M.; Khalizeva, E.; Giuliano, C. J.; Lourido, S.; Flemming, M. D.; Cheeseman, I. M.
10.1101/2025.03.27.645657 — cell biology — Posted on 2025-03-27
616 Beyond One-Size-Fits-All: Tumor Biology Influences Nanoparticle Behaviour in Cancer Models
Bravo, M.; Solis Fernandez, G.; Krzyzowska, S.; Huysecom, S.; Montero Calle, A.; Van Zundert, I.; Louis, B.; Barderas, R.; Fortuni, B.; Rocha, S.
10.1101/2025.03.26.645442 — cell biology — Posted on 2025-03-27
620 Whats left from the brew? Investigating residual barley proteins in spent grains for downstream valorization opportunities
Gregersen Echers, S.; Mikkelsen, R. K.; Abdul-Khalek, N.; Queiroz, L. S.; Hobley, T. J.; Schulz, B. L.; Overgaard, M. T.; Jacobsen, C.; Yesiltas, B.
10.1101/2025.03.26.645420 — plant biology — Posted on 2025-03-27
621 Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritis.
Costa, D.; Hughes, S.; Jenkins, R.; Cardus Figueras, A.; Protty, M.; Tyrrell, V.; Hajeyah, A.; Jones, G. W.; James, B.; Morgan, B.; Monaco, F.; Hill, D.; Morrin, A.; Guy, C.; Bacon, A.; Giera, M.; Toes, R.; Jenkins, V.; Collins, P.; Choy, E.; Jones, S. A.; O'Donnell, V.
10.1101/2025.03.26.645440 — pharmacology and toxicology — Posted on 2025-03-27
622 12/15-Lipoxygenase orchestrates murine wound healing via PPARg-activating oxylipins acting holistically to dampen inflammation.
Thomas, C.; Tyrrell, V.; Burston, J.; Johnson, S.; Aldrovandi, M.; Alvarez Jarreta, J.; Inglis, R.; Leonard, A.; Fice, L.; Costales, J.; Carobbio, S.; Vidal-Puig, A.; Protty, M.; Guy, C.; Andrews, R.; Szomolay, B.; Cossins, B.; Cardus Figueras, A.; Jones, S. A.; O'Donnell, V.
10.1101/2025.03.26.645456 — pharmacology and toxicology — Posted on 2025-03-27
624 β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice
Tyagi, S. C.; Ito, S.; Hubbuch, J. C.; Franklin, M. K.; Howatt, D. A.; Lu, H. S.; Daugherty, A.; Sawada, H.
10.1101/2025.03.24.645113 — pathology — Posted on 2025-03-27
626 Temporal evolution of hemodynamics in murine arteriovenous fistula: a micro-CT based computational fluid dynamics study
Li, L.; Uriyanghai, U.; Wai, C.; Yuan, H.; Livingston, E. W.; Bahnson, E. M.; Sudarsanam, V.; Haddad, S.; Roy-Chaudhury, P.; Griffith, B. E.; Xi, G.
10.1101/2025.03.24.644912 — bioengineering — Posted on 2025-03-27
629 A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
Zeng, C.; Furlan, G.; Almeida, M. V.; Rueda-Silva, J. C.; Price, J.; Mars, J.; Rebelo-Guiomar, P.; Huang, M.; Guang, S.; Butter, F.; Miska, E. A.
10.1101/2025.03.25.645221 — molecular biology — Posted on 2025-03-27
630 CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION
Hebbar Subramanyam, S.; Hriczko, J.; Schulz, S.; Look, T.; Goodarzi, T.; Clarner, T.; Scheld, M.; Kipp, M.; Verjans, E.; Boell, S.; Neullens, C.; Costa, I.; Li, Z.; Gan, L.; Denecke, B.; Schippers, A.; Floess, S.; Huehn, J.; Schmitt, E.; Bopp, T.; Wasmuth, H.; Winograd, R.; Beyaert, R.; Lambrecht, B.; Zenke, M.; Wagner, N.; Ohl, K.; Tenbrock, K.
10.1101/2024.06.29.601312 — immunology — Posted on 2025-03-27
637 Extracellular Nanobody Screening using Conformationally Stable GPCR
Zhang, X.; Gao, K.; Nie, J.; Meng, H.; Sun, X.; Zhao, J.; Liu, X.
10.1101/2025.03.25.645380 — biochemistry — Posted on 2025-03-27
638 Yeast cluster
Braymer, J. J.; Knauer, L.; Crack, J. C.; Oltmanns, J.; Heghmanns, M.; Soares, J. C.; Le Brun, N. E.; Schünemann, V.; Kasanmascheff, M.
10.1101/2025.03.25.644927 — biochemistry — Posted on 2025-03-27
640 STUDIES ON INTERACTION OF MORIN WITH CURLI TO IDENTIFY AGGREGATION NATURE
Roy, T.; Bhat, N.; Sengupta, S.; Banik, S. P.; Bhattacharyya, M.; Basak, P.
10.1101/2025.03.25.645188 — biochemistry — Posted on 2025-03-27
641 Exhaled breath profiling for non-invasive monitoring of cognitive functioning in children
Meurs, J.; Henderson, B.; van Dun, C.; Lopes Batista, G.; Sakkoula, E.; van Diepen, J. A.; Gross, G.; Aarts, E.; Cristescu, S. M.
10.1101/2025.03.25.645320 — biochemistry — Posted on 2025-03-27
643 A GPCR-G protein-β-arrestin megacomplex induced by an allosteric modulator
He, G.; Sun, Q.; Xu, X.; Kong, F.; Zhang, S.; Ye, K.; Sun, X.; Chen, X.; Yan, C.; Liu, X.
10.1101/2025.03.24.645131 — biochemistry — Posted on 2025-03-27
646 Breaking Through Microbial Defences - Organic Acid-Based Deep Eutectic Solvents as a Neoteric Strategy in Bacterial Biofilm, Persister, and Fungal Control
Swebocki, T.; Cieminska, K.; Bortolus, C.; Muchembled, J.; Mechouche, M. S.; Jacquin, J.; Boukherroub, R.; Haddadi, K.; Siah, A.; Sendid, B.; Plotka, M. A.; Kocot, A.
10.1101/2025.03.25.645211 — microbiology — Posted on 2025-03-27
647 Validated Antimalarial Drug Target Discovery using Genome-Scale Metabolic Modelling
Taweechai, S.; Totanes, F. I. G.; Westhead, D.; Herrera-Arozamena, C.; Foster, R.; McConkey, G. A.
10.1101/2025.03.26.645484 — microbiology — Posted on 2025-03-27
648 Totum-448, a polyphenol-rich plant extract, decreases hepatic steatosis and inflammation in diet-induced MASLD mice
Lambooij, J. M.; Chavanelle, V.; Vallier, M.; van der Zande, H. J.; Otero, Y. F.; Otto, F.; Schuurman, R.; Le Joubioux, F.; Maugard, T.; Giera, M.; Peltier, S. L.; Zaldumbide, A.; Sirvent, P.; Guigas, B.
10.1101/2025.03.24.644956 — physiology — Posted on 2025-03-27
649 TP53 Inactivation Confers Resistance to the Menin Inhibitor Revumenib in Acute Myeloid Leukemia
D'Souza, J.; Leung, C. J.; Ballapuram, A. C.; Lin, A. S.; Batingana, A. R.; Lamble, A. J.; Ries, R. E.; Morales, C. E.; Cottonham, C.; Gona, P.; Fan, L.; Ma, X.; Shannon, K.; Meshinchi, S.; Braun, B. S.; Huang, B. J.
10.1101/2025.03.24.644993 — cancer biology — Posted on 2025-03-27
651 EHE cell cultures: a platform for mechanistic and therapeutic investigation
Scalora, N.; DeWane, G.; Drebot, Y.; Khan, A. A.; Sinha, S.; Ghosh, K.; Robinson, D.; Cogswell, P.; Bellizzi, A. M.; Snow, A. N.; Breheny, P.; Chimenti, M. S.; Tanas, M. R.
10.1101/2025.03.24.644191 — cancer biology — Posted on 2025-03-27
652 Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis
Brothwell, M. J.; Cao, G.; Maschek, J. A.; Poss, A. M.; Peterlin, A. D.; Wang, L.; Baker, T. B.; Shahtout, J. L.; Siripoksup, P.; Pearce, Q. J.; Johnson, J. M.; Finger, F. M.; Prola, A.; Pellizzari, S. A.; Hale, G. L.; Manuel, A. M.; Watanabe, S.; Miranda, E. R.; Affolter, K. E.; Tippetts, T. S.; Nikolova, L. S.; Choi, R. H.; Decker, S. T.; Patil, M.; Catrow, J. L.; Holland, W. L.; Nowinski, S. M.; Lark, D. S.; Fisher-Wellman, K. H.; Mimche, P. N.; Evason, K. J.; Cox, J. E.; Summers, S. A.; Gerhart-Hines, Z.; Funai, K.
10.1101/2024.10.10.617517 — biochemistry — Posted on 2025-03-27
653 SNP panel for non-invasive genotyping of leopard (Panthera pardus)
Spong, G.; Bertola, L.; De Vry, A. M.; Dussex, N.; Shiffthaler, B.; Paijmans, J.; Hofreiter, M.; Forbes, R.; Kerley, G.; Everatt, K.; Chifunte, C.; Becker, M.; Creel, S.; Bourgeois, S.; Drouilly, M.; Mamugy, F.
10.1101/2024.11.01.621452 — genetics — Posted on 2025-03-27
654 Evolutionary responses and genomic consequences of polyploidization in natural populations of Orychophragmus
Lai, Q.; Wang, Z.; Jia, C.; Qumu, X.; Wang, R.; Zhao, Z.; Liu, Y.; Hou, Y.; Liu, J.; Ingvarsson, P. K.; Wang, J.
10.1101/2025.03.24.644964 — evolutionary biology — Posted on 2025-03-27
655 The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
Zhang, F.; Wang, Y.; Zhang, L.; Wang, C.; Chen, D.; Liu, H.; Xu, R.; Haynes, C. M.; Shim, J.-H.; Ge, X.
10.1101/2020.08.03.233874 — cell biology — Posted on 2025-03-27
656 Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish infection
Gifford, H.; Bedekovic, T.; Helmstetter, N.; Gregory, J.; Ma, Q.; Brand, A. C.; Wilson, D.; Rhodes, J.; Ramsdale, M.; Kudoh, T.; Farrer, R. A.
10.1101/2024.10.22.619744 — microbiology — Posted on 2025-03-27
658 The Growing Little Brain: Cerebellar Functional Development from Cradle to School
Lyu, W.; Thung, K.-H.; Huynh, K. M.; Wang, L.; Lin, W.; Ahmad, S.; Yap, P.-T.
10.1101/2024.10.12.617938 — neuroscience — Posted on 2025-03-27
659 The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured Brain.
Kansakar, S. B.; Sterben, S. P.; Anamala, C. C.; Thielen, M. D.; Liaudanskaya, V.
10.1101/2025.03.19.644244 — neuroscience — Posted on 2025-03-27
661 Synaptopathy in the TDP43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis
Avayzian-Hancock, A.; Butler, E.; Meehan, C. F.; Miles, G. B.; Broadhead, M. J.
10.1101/2025.03.25.645173 — neuroscience — Posted on 2025-03-27
666 Behavioral and neural correlates of social hierarchy formation in a sex-changing fish
Quertermous, H. M.; Kamstra, K.; van der Burg, C. A.; Muncaster, S.; Todd, E. V.; Jasoni, C. L.; Brown, C.; Gemmell, N. J.
10.1101/2024.07.04.602141 — animal behavior and cognition — Posted on 2025-03-27
667 MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis
Muncie-Vasic, J. M.; Sinha, T.; Clark, A. P.; Brower, E. F.; Saucerman, J. J.; Black, B. L.; Bruneau, B. G.
10.1101/2024.11.01.621613 — developmental biology — Posted on 2025-03-27
671 A vectorial code for semantics in human hippocampus
Franch, M.; Mickiewicz, E. A.; Belanger, J.; Chericoni, A.; Chavez, A. G.; Katlowitz, K.; Mathura, R.; Bartoli, E.; Kemmer, S.; Piantadosi, S. T.; Provenza, N.; Watrous, A.; Sheth, S.; Hayden, B.
10.1101/2025.02.21.639601 — neuroscience — Posted on 2025-03-27
672 N-Glycans Modulate HIV-1 Env Conformational Plasticity
Shehata, M.; Casalino, L.; Duquette, M.; Chen, S.; Flaherty, A.; Villa, E.; Amaro, R. E.
10.1101/2025.03.26.645577 — biophysics — Posted on 2025-03-26
673 AI-Driven Efficient De Novo design of GLP-1RAs with Extended Half-Life and Enhanced Efficacy
Wei, T.; Cui, X.; Lin, J.; Zheng, Z.; Cui, T.; Cheng, L.; Lin, X.; Zhu, J.; Ran, X.; Hong, X.; Yu, Z.; Chen, H.
10.1101/2025.03.26.645438 — bioengineering — Posted on 2025-03-26
676 IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
Plattner, C.; Sturm, G.; Kuehl, A. A.; Atreya, R.; Carollo, S.; Gronauer, R.; Rieder, D.; Guenther, M.; Ormanns, S.; Manzl, C.; Meneghetti, A. R.; Hegazy, A.; Patankar, J.; Carrero, Z. I.; TRR241 IBDome Consortium, ; Neurath, M. F.; Kather, J. N.; Becker, C.; Siegmund, B.; Trajanoski, Z.
10.1101/2025.03.26.645544 — molecular biology — Posted on 2025-03-26
677 A proteome-wide, MS-based screen identifies SUMOylation of host RNA splicing factors induced by HIV-1 infection
Kelenis, D. P.; Johnson, J. R.; Sidoli, S.; Emery, A.; Swanstrom, R. I.; Hawkins, L. J.; Pawar, T.; Goff, S. P.
10.1101/2025.03.26.645526 — molecular biology — Posted on 2025-03-26
678 Directed evolution expands CRISPR-Cas12a genome editing capacity
Ma, E.; Chen, K.; Shi, H.; Wasko, K. M.; Esain-Garcia, I.; Trinidad, M. I.; Zhou, K.; Ye, J.; Doudna, J. A.
10.1101/2025.03.26.645588 — biochemistry — Posted on 2025-03-26
681 Structural basis of antiphage defense by an ATPase-associated reverse transcriptase
George, J. T.; Burman, N.; Wilkinson, R. A.; de Silva, S.; McKelvey-Pham, Q.; Buyukyoruk, M.; Dale, A.; Landman, H.; Graham, A.; DeLuca, S. Z.; Wiedenheft, B.
10.1101/2025.03.26.645336 — biochemistry — Posted on 2025-03-26
684 Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Agarwal, G.; Antoszewski, M.; Xie, X.; Pershad, Y.; Arora, U. P.; Poon, C.-L.; Lyu, P.; Lee, A. J.; Guo, C.-J.; Ye, T.; Norford, L. B.; Neehus, A.-L.; della Volpe, L.; Wahlster, L.; Ranasinghe, D.; Ho, T.-C.; Barlowe, T. S.; Chow, A.; Schurer, A.; Taggart, J.; Durham, B. H.; Abdel-Wahab, O.; McGraw, K. L.; Allan, J. M.; Soldatov, R.; Bick, A. G.; Kharas, M. G.; Sankaran, V. G.
10.1101/2025.03.24.645017 — genetics — Posted on 2025-03-26
690 Charged mutations in the FUS low-complexity domain modulate condensate ageing kinetics
Pedraza, E.; Hoyos, D.; Feito, A.; Gamez, F.; Sanchez-Burgos, I.; Collepardo-Guevara, R.; R. Tejedor, A.; R. Espinosa, J.
10.1101/2025.03.26.645197 — biophysics — Posted on 2025-03-26
691 De novo design of inducibly assembling multi-component filaments
Shen, H.; Lynch, E. M.; Jameson, N.; Decarreau, J.; Shi, C.; Chen, Z.; Sheffler, W.; Xu, M.; De Yoreo, J. J.; Zalatan, J. G.; Kollman, J. M.; Baker, D.
10.1101/2025.03.26.645066 — bioengineering — Posted on 2025-03-26
693 Structural Basis of CSN-mediated SCF Deneddylation
Enchev, R. I.; Ding, S.; Clapperton, J. A.; Maeots, M.-E.; Kunzelmann, S.; Shaaban, M.
10.1101/2025.03.25.645352 — biochemistry — Posted on 2025-03-26
694 PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB
Readshaw, J.; Doyle, L.; Puiu, M.; Kelly, A.; Nelson, A.; Kaiser, A.; McGuire, S.; Peralata-Acosta, J.; Smith, D.; Stoddard, B. L.; Kaiser, B. K.; Blower, T. R.
10.1101/2025.03.26.645558 — biochemistry — Posted on 2025-03-26
695 COX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
Cunatova, K.; Vrbacky, M.; Knezu, M.; Pecinova, A.; Alan, L.; Houstek, J.; Fernandez-Vizarra, E.; Mracek, T.; Pecina, P.
10.1101/2025.03.25.645161 — biochemistry — Posted on 2025-03-26
696 Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry
Ebberink, E. H. T. M.; Desligniere, E. R. L.; Ruisinger, A.; Nuebel, M.; Thomann, M.; Heck, A. J. R.
10.1101/2025.03.25.645154 — biochemistry — Posted on 2025-03-26
697 Phase separation of Polycomb-like (PCL) proteins drive PRC2 complex condensates to regulate gene expression
Peng, S.; Zhang, B.; Jin, L.; Xu, H.; Stielow, B.; Geller, M.; Wang, C.; Zhang, M.; Luo, X.; Wang, X.; Jiang, M.; Gao, X.; Cai, Q.; Sun, F.; Liefke, R.; Gao, R.; Chen, S.
10.1101/2025.03.26.645482 — biochemistry — Posted on 2025-03-26
698 STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers
Rutledge, B. S.; Wilson, C. J.; Lau, R. M.; Jurado-Coronel, J. C.; del Cid Pellitero, E.; Karttunen, M.; Durcan, T.; Fon, E. A.; Prado, M.; Legleiter, J.; Duennwald, M. L.; Choy, W.-Y.
10.1101/2025.03.26.645247 — biochemistry — Posted on 2025-03-26
699 Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase
Yehorova, D.; Alansson, N.; Shen, R.; Denson, J. M.; Robinson, M.; Risso, V. A.; Molina, N. R.; Loria, J. P.; Gaucher, E.; Sanchez-Ruiz, J. M.; Hengge, A. C.; Johnson, S.; Kamerlin, S. C. L.
10.1101/2025.03.26.645524 — biochemistry — Posted on 2025-03-26
701 The origin, invasion history and resistance architecture of Anopheles stephensi in Africa.
Dennis, T. P. W.; Sulieman, J. E.; Abdin, M.; Ashine, T.; Asmamaw, Y.; Eyasu, A.; Simma, E. A.; Zemene, E.; Negash, N.; Kochora, A.; Assefa, M.; Elzack, H. S.; Dagne, A.; Lukas, B.; Bulto, M. G.; Epstein, A.; Brown, R.; Enayati, A.; Nikpoor, F.; Al-Nazawi, A. M.; Al-Zahrani, M. H.; Khaireh, B. A.; Kayed, S.; Abdi, A.-I. A.; Allan, R.; Ashraf, F.; Pignatelli, P.; Morris, M.; Nagi, S. C.; Lucas, E. R.; Sherrard-Smith, E.; Hernandez-Koutoucheva, A.; Doumbe-Belisse, P.; Reynolds, A. M.; Wilson, A. L.; Yewhalaw, D.; Gadisa, E.; Malik, E.; Kafy, H. T.; Donnelly, M. J.; Weetman, D.
10.1101/2025.03.24.644828 — genomics — Posted on 2025-03-26
704 Cracking the egg: Isolation and discovery of distinct nonvesicular extracellular particles from Schistosoma mansoni eggs
Rogers, M. J.; Androsso, A.; Billakanti, J.; Duke, M. G.; Lu, Y.; Collinson, N.; Tan, J.; Macia, L.; Koifman, N.; Floetenmeyer, M.; Jones, M. K.; Gordon, C.; Navarro, S.
10.1101/2025.03.24.645107 — molecular biology — Posted on 2025-03-26
705 Cumulative TF binding and H3K27 Acetylation drive enhancer activation frequency
Baderna, V.; Barzaghi, G.; Kleinendorst, R.; Chatsirisupachai, K.; Moniot-Perron, L.; Schopp, M.; Hochepied, T.; Libert, C.; Odom, D. T.; Zaugg, J. B.; Krebs, A. R.
10.1101/2025.03.26.645413 — molecular biology — Posted on 2025-03-26
706 Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8+ T-cells reveal strong functional impairment and recognition bias as markers for disease severity
Amaya Hernandez, S. P.; Munk, K. K.; Danilov, K.; Kadivar, M.; Hersby, D. S.; Tamhane, T.; Stegenborg-Grathwohl, S. M.; Gang, A. O.; Hadrup, S. R.; Saini, S. K.
10.1101/2025.03.25.644515 — immunology — Posted on 2025-03-26
707 Substrate recognition by human separase
Yu, J.; Schmidt, S.; Botto, M.; Lee, K.; Ghent, C. M.; Goodfried, J. M.; Howe, A.; O'Reilly, F. J.; Morgan, D. O.; Boland, A.
10.1101/2025.03.24.644901 — biochemistry — Posted on 2025-03-26
709 Global Metagenomics Reveals Hidden Protist Diversity
Gutierrez, M. F. R.; Krinos, A. I.; Alcala, X. M.; Burns, J. A.; Stepanauskas, R.; Woyke, T.; Schulz, F.
10.1101/2025.03.26.645542 — microbiology — Posted on 2025-03-26
710 Defining the host dependencies and the transcriptional landscape of RSV infection and bystander activation
Sunshine, S.; Puschnik, A.; Retallack, H.; Laurie, M. T.; Liu, J.; Peng, D.; Knopp, K.; Zinter, M. S.; Ye, C. J.; DeRisi, J. L.
10.1101/2025.03.26.645108 — microbiology — Posted on 2025-03-26
713 Structures of the honeybee GABAA RDL receptor illuminate allosteric modulation
Laboure, T.; Pandey, M. P.; Zarkadas, E.; Juillan-Binard, C.; Baud, D.; Neyton, J.; Cens, T.; Rousset, M.; Dehez, F.; Charnet, P.; Nury, H.
10.1101/2025.03.24.644576 — biophysics — Posted on 2025-03-26
719 A Phosphopantetheinyl Transferase from Dictyobacter vulcani sp. W12 Expands the Combinatorial Biosynthetic Toolkit
Hsu, K. K.; Ferguson, C. M.; McBride, C. M.; Mostaghim, N. B.; Mabry, K. N.; Fairman, R.; Cho, Y. I.; Charkoudian, L.
10.1101/2025.03.24.645039 — biochemistry — Posted on 2025-03-26
721 A method for the detection and enrichment of endogenous cereblon substrates
Lloyd, H. C.; Li, Y.; Payne, N. C.; Zhao, Z.; Xu, W.; Kroupova, A.; Zollman, D.; Long, T.; Chen, M.; Kabir, F.; Freeman, R.; Feng, E. Y.; Xi, S.; Hsu, Y.-C.; Ciulli, A.; Mazitschek, R.; Woo, C. M.
10.1101/2025.03.24.645063 — biochemistry — Posted on 2025-03-26
722 SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice
Biashad, S. A.; Hillpot, E.; Morandini, F.; Rechsteiner, C.; Paige, V.; Tombline, G.; Lee, M.; Zheng, Z.; Liang, Y.; Martinez, J. C.; Sieczkiewicz, N.; Zhang, Z.; Volobaev, V.; Firsanov, D.; Simon, M.; Zhang, L.; Robbins, P. D.; Seluanov, A.; Gorbunova, V.
10.1101/2025.03.24.645072 — molecular biology — Posted on 2025-03-26
723 Evolutionary responses and genomic consequences of polyploidization in natural populations of Orychophragmus
Lai, Q.; Wang, Z.; Jia, C.; Qumu, X.; Wang, R.; Zhao, Z.; Liu, Y.; Hou, Y.; Liu, J.; Ingvarsson, P. K.; Wang, J.
10.1101/2025.03.24.644964 — molecular biology — Posted on 2025-03-26
724 Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection
Deruelle, V.; Dupuis, G.; Raoux-Barbot, D.; Lim, E.; Ponce-Lopez, R.; Ladant, D.; Renault, L.; Mechold, U.
10.1101/2025.03.26.645418 — microbiology — Posted on 2025-03-26
726 Anaerobic protist survival in microcosms is dependent on microbiome metabolic function.
Aguilera-Campos, K. I.; Boisard, J.; Törnblom, V.; Jerlström-Hultqvist, J.; Behncke-Serra, A.; Cotillas, E. A.; Stairs, C.
10.1101/2025.03.26.644077 — microbiology — Posted on 2025-03-26
728 PacL-organized membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis
Dupuy, P.; Boudehen, Y.-M.; Faucher, M.; Buglino, J. A.; Fay, A.; Cantaloube, S.; Grimoire, Y.; Marcoux, J.; Levet, F.; Bettarel, L.; Voisin, B.; Rech, J.; Bouet, J.-Y.; Saurel, O.; Sibarita, J.-B.; Glickman, M.; Gutierrez, C.; Neyrolles, O.
10.1101/2025.03.25.645379 — microbiology — Posted on 2025-03-26
729 Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection
Hecht, A. L.; Mahmud, N.; Chaudhry, S.; Cao, J. Y.; Branigan, G. P.; Lee, J.; Theiller, E.; Roggiani, M.; Friedman, E. S.; Herman, L.; Gallis, B. E.; Jones, S. M.; Planet, P. J.; Zackular, J. P.; Kaplan, D. E.; Serper, M.; Reddy, K. R.; Moustafa, A. M.; Goulian, M.; Wu, G. D.
10.1101/2025.03.26.645536 — microbiology — Posted on 2025-03-26
731 The skin commensal yeast Malassezia promotes tissue homeostasis via the aryl hydrocarbon receptor.
Ibanez, E. G.; Stockmaier, M.; Barone, G.; Staropoli, A.; Karakaya, T.; Beer, H.-D.; Vinale, F.; Ianiri, G.; LeibundGut-Landmann, S.
10.1101/2025.03.26.645515 — microbiology — Posted on 2025-03-26
732 Visualizing the transcription and replication of influenza A viral RNAs in cells by multiple direct RNA padlock probing and in-situ sequencing (mudRapp-seq)
Ahmad, S.; Li, J.; Schaust, J.; Gribling-Burrer, A.-S.; Geiger, N.; Fischer, S. C.; Ambi, U. B.; Backes, S.; Ankenbrand, M. J.; Smyth, R. P.
10.1101/2025.03.26.645430 — microbiology — Posted on 2025-03-26
733 Pre-assembly of biomolecular condensate seeds drives RSV replication
Ratnayake, D.; Galloux, M.; Boersma, S.; Sizun, C.; Sourimant, J.; Lakerveld, A. J.; Baars, M. J. D.; Banerjee, R.; Noerenberg, M.; Dreier, B.; Furler, S.; Castello, A.; Plückthun, A.; Eleouët, J.-F.; van Kasteren, P. B.; Rameix-Welti, M.-A.; Tanenbaum, M. E.
10.1101/2025.03.26.645422 — microbiology — Posted on 2025-03-26
734 Single-dose VSV-Sudan virus vaccine protects from lethal Sudan virus infection within one week: a challenge study in macaques
Fletcher, P.; O'Donnell, K. L.; Feldmann, F.; Rhoderick, J. F.; Clancy, C. S.; Prator, C. A.; Smith, B. J.; Gunn, B. M.; Feldmann, H.; Marzi, A.
10.1101/2025.03.26.645555 — microbiology — Posted on 2025-03-26
735 Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Kussick, E.; Johansen, N.; Taskin, N.; Chowdhury, A.; Quinlan, M. A.; Fraser, A.; Clark, A. G.; Wynalda, B.; Martinez, R.; Groce, E. L.; Reding, M.; Liang, E.; Shulga, L.; Huang, C.; Casper, T.; Clark, M.; Ho, W.; Gao, Y.; van Velthoven, C. T. J.; Sobieski, C.; Ferrer, R.; Berg, M. R.; Curtis, B. C.; English, C.; Day, J. C.; Fortuna, M. G.; Donadio, N.; Newman, D.; Yao, S.; Chakka, A. B.; Goldy, J.; Torkelson, A.; Guzman, J. B.; Chakrabarty, R.; Nguy, B.; Guilford, N.; Pham, T. H.; Wright, V.; Ronellenfitch, K.; Naidoo, R.; Kenney, J.; Williford, A.; Ramakrishnan, C.; Drinnenberg, A.; Gudsnuk,
10.1101/2024.07.30.605864 — neuroscience — Posted on 2025-03-26
738 Next-Generation Mapping of the ACINUS-Mediated Alternative Splicing Machinery and Its Regulation by O-glycosylation in Arabidopsis
Shrestha, R.; Reyes, A. V.; Carey, S.; Karunadasa, S. S.; Zhai, W.; Byun, D.; Lin, W.-D.; Li, J.; Alerte, K.; Cui, H.; Wang, Z.-Y.; Xu, S.-L.
10.1101/2025.01.04.631329 — plant biology — Posted on 2025-03-26
740 FastGxC: Fast and Powerful Context-Specific eQTL Mapping in Bulk and Single-Cell Data
Krockenberger, L.; Lu, A.; Thompson, M.; Liu, C.; Gordon, M. G.; Ramste, A.; Carcamo-Orive, I.; Knowles, J. W.; Dahl, A.; Ye, C. J.; Zaitlen, N.; Balliu, B.
10.1101/2021.06.17.448889 — genomics — Posted on 2025-03-26
742 Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity
Wu, Y.; Song, Y.; Soto, J.; Hoffman, T.; Lin, X.; Zhang, A.; Chen, S.; Massad, R. N.; Han, X.; Qi, D.; Yeh, K.-W.; Fang, Z.; Eoh, J.; Gu, L.; Rowat, A. C.; Gu, Z.; Li, S.
10.1101/2024.04.14.589442 — cell biology — Posted on 2025-03-26
744 Complete genome sequences of Fusobacterium watanabei sp. isolates
Zepeda-Rivera, M. A.; Ponath, F.; Lewis, K. N.; Gavate, R. P.; Dewhirst, F. E.; Tomida, J.; Kawamura, Y.; Tanaka, K.; Bullman, S.; Johnston, C. D.
10.1101/2025.03.25.645266 — microbiology — Posted on 2025-03-26
745 Epigenetic phase variation in the gut microbiome enhances bacterial adaptation
Ni, M.; Fan, Y.; Liu, Y.; Li, Y.; Qiao, W.; Davey, L. E.; Zhang, X.-S.; Ksiezarek, M.; Mead, E. A.; Tourancheau, A.; Jiang, W.; Blaser, M. J.; Valdivia, R.; Fang, G.
10.1101/2025.01.11.632565 — microbiology — Posted on 2025-03-26
749 PET-derived amyloid patterns in gray and white matter across Alzheimer's disease: A high-model-order ICA
Khasayeva, N.; Jensen, K. M.; Eierud, C.; Petropoulos, H.; Levey, A. I.; Lah, J.; Luo, R.; Premi, E.; Borroni, B.; Chen, J.; Calhoun, V.; Iraji, A.
10.1101/2025.03.21.644614 — neuroscience — Posted on 2025-03-26
753 Mechanisms driving collective escape patterns in starling flocks
Papadopoulou, M.; Hildenbrandt, H.; Storms, R. F.; Carere, C.; Verhulst, S.; Hemelrijk, C. K.
10.1101/2024.10.27.620514 — animal behavior and cognition — Posted on 2025-03-26
756 Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)
Beretta, S.; Tettamanti, M.; Mariani, J.; Diamanti, S.; Valente, A.; Cuomo, O.; Di Santo, C.; Dettori, I.; Venturini, M.; Bulli, I.; Coppi, E.; Montano Castillo, M. A.; Butti, E.; Gullotta, G. S.; Vigano, M.; Santangelo, F.; Pedrazzini, F. A.; Perego, C.; Seminara, S.; Anzilotti, S.; Rzemieniec, J.; Castiglioni, L.; Mercuriali, B.; Muluhie, M.; Zoia, C. P.; Sala, G.; Sironi, L.; Bacigaluppi, M.; Martino, G.; Pedata, F.; Pugliese, A. M.; Amantea, D.; Bagetta, G.; Vinciguerra, A.; Pignataro, G.; Fumagalli, S.; De Simoni, M.-G.; Ferrarese, C.
10.1101/2025.03.25.645373 — neuroscience — Posted on 2025-03-26
757 Chronic dietary ingestion of Bacillus thuringiensis spores promotes intestinal inflammation and aging in non-target adult Drosophila
Joly, A.; Soltys, J.; Finkelstein, J.; Rancurel, C.; Amate, A.; Nawrot-Esposito, M.-P.; Chassaing, B.; Gallet, A.; Rousset, R.
10.1101/2025.03.25.645302 — physiology — Posted on 2025-03-26
760 Inhibition of cytosolic DNA sensing and transposon activity safeguards pluripotency
Garcia-Llagostera, F.; Putman, A. L.; Choromidis, A.; Leeke, B. J.; Stanik, K.; Ramos-Guzman, A.; Moyon, B.; Gil, J.; Barr, A. R.; Percharde, M.
10.1101/2025.03.26.645264 — developmental biology — Posted on 2025-03-26
762 Proton-secreting cells modulate mucosal immune surveillance in the male reproductive tract
Da Silva, A.; Barrachina, F.; Avenatti, M. C.; Elizagaray, M. L.; Bastepe, I.; Sasso-Cerri, E.; Battistone, M. A.
10.1101/2025.03.26.645301 — developmental biology — Posted on 2025-03-26
763 SARS-CoV-2 infection enhancement by Amphotericin B: Implications for disease management
Nguyen, D.; Laidlaw, S. M.; Dong, X.; Wand, M. E.; Horton, A.; Sutton, M.; Tree, J.; Milligan, R.; Erdmann, M.; Matthews, D. A.; Davidson, A. D.; Rahman, K. M.; Hiscox, J. A.; Carroll, M. W.
10.1101/2024.11.07.622419 — microbiology — Posted on 2025-03-26
764 Sleep-Modulated Cross-Frequency Coupling Between δ Phase and β-γ Bistability: A System-Level Modulation of Epileptic Activity
Burlando, G.; Belforte, C.; Siebenhühner, F.; Di Tullio, L.; Chiarella, L.; Myrov, V.; Zubler, F.; Roascio, M.; Cardinale, F.; Palva, S.; Palva, J. M.; Nobili, L.; Arnulfo, G.; Wang, S. H.
10.1101/2025.03.25.642592 — neuroscience — Posted on 2025-03-26
765 TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients
Ghirotto, B.; Goncalves, L. E.; Ruder, V.; James, C.; Gerasimova, E.; Rizo, T.; Wend, H.; Farrell, M.; Gerez, J. A.; Prymaczok, N. C.; Kuijs, M.; Shulman, M.; Hartebrodt, A.; Prots, I.; Gessner, A.; Zunke, F.; Winkler, J.; Blumenthal, D. B.; Theis, F. J.; Riek, R.; Günther, C.; Neurath, M.; Gupta, P.; Winner, B.
10.1101/2025.03.25.644826 — neuroscience — Posted on 2025-03-26
766 The gut microbiome in early age-related macular degeneration
Feigl, B.; Adhikari, P.; Huygens, F.; Jayasundara, N. K.; Zele, A. K.
10.1101/2025.03.25.645132 — neuroscience — Posted on 2025-03-26
767 iGABASnFR2: Improved genetically encoded protein sensors of GABA
Kolb, I.; Hasseman, J. P.; Matsumoto, A.; Arthur, B. J.; Zhang, Y.; Tsang, A.; Reep, D.; Tsegaye, G.; Zheng, J.; Patel, R.; Looger, L. L.; Marvin, J. S.; Korff, W. L.; Yonehara, K.; Turner, G. C.
10.1101/2025.03.25.644953 — neuroscience — Posted on 2025-03-26
768 Personalized mapping of inhibitory spinal circuits via neural decoding of high-density electromyography and in silico modelling
Pascual-Valdunciel, A.; Consul, N.; Brownstone, R. M.; Beato, M.; Farina, D.; Nascimento, F.; Ozyurt, M. G.
10.1101/2025.03.25.645235 — neuroscience — Posted on 2025-03-26
772 Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A
Yi, J.; Yang, L.; Widman, A. J.; Toliver, A.; Bertels, Z.; Del Rosario, J. S.; Slivicki, R. A.; Payne, M.; Dourson, A. J.; Li, J.-N.; Kumar, R.; Gupta, P.; Mwirigi, J. M.; Chamessian, A.; Lemen, J.; Copits, B. A.; Gereau, R. W.
10.1101/2025.03.25.645367 — neuroscience — Posted on 2025-03-26
775 Temporal dynamics of proteome and phosphorproteome during neuronal differentiation in the reference KOLF2.1J iPSC line
Hao, Y.; Li, Z.; Lara, E.; Ramos, D. M.; Santiana, M.; Jin, B.; Epstein, J.; Camacho, J.; Carmiol, N.; Kowal, I.; Jarreau, P.; Weller, C. A.; Klaisner, S.; Screven, L. A.; Pantazis, C. B.; Nalls, M. A.; Narayan, P.; Ferrucci, L.; Singleton, A. B.; Ward, M. E.; Cookson, M. R.; Qi, Y. A.
10.1101/2025.03.25.645331 — neuroscience — Posted on 2025-03-26
776 Lipidomics profiling identifies β-oxidation as a key process in noise-induced hearing loss
Wallace, G.; Ji, L.; Cassinotti, L. R.; Kachman, M.; Lyssiotis, C. A.; Burant, C. F.; Corfas, G.
10.1101/2025.03.25.645361 — neuroscience — Posted on 2025-03-26
778 Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice
van der Zouwen, C. I.; Tello, A. J.; Suresh, J. S.; Duque-Yate, J.; Hsu, T.; Konanur, V.; Boutin, J.; Roitman, M. F.; Ryczko, D.
10.1101/2025.03.25.645329 — neuroscience — Posted on 2025-03-26
779 Long-term editing of brain circuits in mice using an engineered electrical synapse
Ransey, E.; Thomas, G.; Wisdom, E.; Almoril-Porras, A.; Bowman, R.; Adamson, E.; Walder-Christensen, K. K.; White, J. A.; Hughes, D. N.; Schwennesen, H.; Ferguson, C.; Tye, K.; Mague, S. D.; Niu, L.-G.; Wang, Z.-W.; Colon-Ramos, D.; Hultman, R.; Bursac, N.; Dzirasa, K.
10.1101/2025.03.25.645291 — neuroscience — Posted on 2025-03-26
781 Growth charts of infant visual neurodevelopment generalize across global contexts
Margolis, E. T.; Camp, C.; Sobrino, A. C.; Polanczyk, G. V.; Fatori, D.; Khula South Africa Team, ; Germina Team, ; LABS Team, ; GABA Team, ; 1kD EEG Working Group, ; 1kD Machine Learning Working Group, ; Cornelissen, L.; Berde, C. B.; Hensch, T. K.; Nelson, C. A.; Shephard, E.; Donald, K. A.; Scheinost, D.; Gabard-Durnam, L. J.
10.1101/2025.03.25.645314 — neuroscience — Posted on 2025-03-26
782 Cardiac-specific GCN5L1 deficiency promotes MASLD in HFpEF
Bugga, P.; Mushala, B. A.; Stoner, M. W.; Manning, J. R.; Bhattarai, N.; Sharifi-Sanjani, M.; Vandevender, A.; Mooli, R. G.; Ramakrishnan, S. K.; Kaufman, B. A.; Shiva, S. S.; Happe, C. L.; Mullett, S. J.; Gelhaus, S. L.; Jurczak, M. J.; Scott, I.
10.1101/2025.02.05.636634 — physiology — Posted on 2025-03-26
783 Microwave emission from bees
Goryanin, I.; Lair, X.; Vesnin, S.; Goryanin, I.
10.1101/2025.03.24.644736 — biophysics — Posted on 2025-03-26
785 Milking it: repeated post-weaning suckling events in Galapagos Sea Lions Zalophus Wollebaeki
Childs, A.; Feldmann, C.; Stoehr, S.; Demarthon, R.; Piedrahita, P.; Twiss, S. D.; Krüger, O.
10.1101/2025.03.26.645415 — animal behavior and cognition — Posted on 2025-03-26
790 Combination of Cas9 and adeno-associated vectors (AAVs) enables efficient in vivo knockdown of precise miRNAs in the rodent brain
Roura-Martinez, D.; Popa, N.; Jaouen, F.; Rombaut, C.; Lepolard, C.; Borges, A.; Bachar, D.; Cazorla, M.; Villet, M.; Moreno, S.; Marie, H.; GASCON, E.
10.1101/2025.03.26.645225 — neuroscience — Posted on 2025-03-26
791 SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses
Mani, A.; Mendel, M.; Westwood, P.; Bonardi, C.; Saal, W.; Topp, A.; Bilyard, M.; Brigo, A.; Wittwer, M. B.; Benz, J.; Kuhn, B.; Haider, A.; Giroud, M.; Keaney, J.
10.1101/2025.03.25.644293 — neuroscience — Posted on 2025-03-26
792 Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease
Badina, A. M.; Ceyzeriat, K.; Amosse, Q.; Tresh, A.; Abjean, L.; Guenat, L.; Vauthey, E.; Tsartsalis, S.; Millet, P.; Tournier, B. B.
10.1101/2025.03.25.645240 — neuroscience — Posted on 2025-03-26
794 Unexpected mechanisms of sex-specific memory vulnerabilities to acute traumatic stress
Hokenson, R. E.; Rodriguez-Acevedo, K. L.; Chen, Y.; Short, A. K.; Samrari, S. A.; Devireddy, B.; Jensen, B. J.; Winter, J. J.; Gall, C. M.; Soma, K. K.; Heller, E. A.; Baram, T. Z.
10.1101/2025.03.25.645300 — neuroscience — Posted on 2025-03-26
795 Beyond ROIs: Laminar fMRI Mapping with Cylarim
Lohmann, G.; Steiglechner, J.; Mahler, L.; Scheffler, K.
10.1101/2025.03.25.645237 — neuroscience — Posted on 2025-03-26
796 Comparative analysis of nuclei isolation methods for brain single-nucleus RNA sequencing
Kersey, H. N.; Acri, D. J.; Dabin, L. C.; Hartigan, K. A.; Mustaklem, R.; Park, J. H.; Kim, J.
10.1101/2025.03.25.645306 — neuroscience — Posted on 2025-03-26
800 Cold Receptor TRPM8 as a target for Migraine-associated Pain and Affective Comorbidities
Cabanero, D.; Carter, E. P.; Gonzalez-Cano, R.; Cobos, E. J.; Fernandez-Carvajal, A.; Ferrer-Montiel, A.
10.1101/2025.03.25.645275 — neuroscience — Posted on 2025-03-26
801 Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers
Sanchez-Todo, R.; Mercadal, B.; Lopez-Sola, E.; Guasch-Morgades, M.; Deco, G.; Ruffini, G.
10.1101/2025.03.26.645407 — neuroscience — Posted on 2025-03-26
803 Temporal coding enables hyperacuity in event based vision
Assa, E.; Rivkind, A.; Kreiserman, M.; Khan, F. S.; Khan, S.; Ahissar, E.
10.1101/2025.03.25.645190 — neuroscience — Posted on 2025-03-26
805 Synaptopathy in the TDP43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis
Avayzian-Hancock, A.; Butler, E.; Meehan, C. F.; Miles, G. B.; Broadhead, M. J.
10.1101/2025.03.25.645173 — neuroscience — Posted on 2025-03-26
806 ELF3 controls trait heterogeneity by tuning the rate of maturation in Arabidopsis and barley
McCarthy, K.; Pook, H.; Redmond, E. J.; Ronald, J.; Keir, J.; Zhu, Z.; Quint, M.; Davis, P. A.; Hartley, S. E.; Davis, S.; Ezer, D.
10.1101/2025.03.24.644900 — plant biology — Posted on 2025-03-26
807 Loss of tomato geranylgeranyl diphosphate synthase 2 increases monoterpenoid levels and enhances immune responses to bacterial infection
Perez-Perez, J.; Ezquerro, M.; Lim, S.; Ha, S.-H. S. H.; Lopez-Gresa, M. P.; Rodriguez-Concepcion, M.; Lison, P.
10.1101/2025.03.24.644926 — plant biology — Posted on 2025-03-26
809 Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback
Kwakye, A.; Reid, K.; Wund, M. A.; Heins, D. C.; Bell, M. A.; Veeramah, K. R.
10.1101/2025.03.25.642177 — evolutionary biology — Posted on 2025-03-26
810 A novel supergene controls queen size and colony social organization in the ant Myrmica ruginodis
Sigeman, H.; Seppä, P.; Downing, P. A.; Webster, M. T.; Helanterä, H.; Viljakainen, L.
10.1101/2025.03.24.644106 — evolutionary biology — Posted on 2025-03-26
812 The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence
Zhang, F.; Wang, Y.; Zhang, L.; Wang, C.; Chen, D.; Liu, H.; Xu, R.; Haynes, C. M.; Shim, J.-H.; Ge, X.
10.1101/2020.08.03.233874 — cell biology — Posted on 2025-03-26
813 Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells
Ernhofer, B.; Spittler, A.; Ferk, F.; Misik, M.; Zylka, M. M.; Glatt, L.; Boettiger, K.; Solta, A.; Kirchhofer, D.; Timelthaler, G.; Megyesfalvi, Z.; Kopatz, V.; Kovar, H.; Knasmueller, S.; Aigner, C.; Kenner, L.; Dome, B.; Schelch, K.
10.1101/2025.03.24.644975 — molecular biology — Posted on 2025-03-26
814 Complete genome sequences of Fusobacterium watanabei sp. isolates
Zepeda Rivera, M. A.; Ponath, F.; Lewis, K. N.; Gavate, R. P.; Dewhirst, F. E.; Tomida, J.; Kawamura, Y.; Tanaka, K.; Bullman, S.; Johnston, C. D.
10.1101/2025.03.25.645266 — microbiology — Posted on 2025-03-26
815 Strain Matters: The 129S1/SvlmJ Mouse Model Reveals the Genetic and Inflammatory Susceptibility to Hypertensive Complications
Orieux, A.; Boulestreau, R.; Bats, M.-L.; Michot, M.; Boyer, A.; Dinet, V.; Vaurs, J.; Dufourcq, P.; Peghaire, C.; DUPLAA, c.; Couffinhal, T.; Rubin, S.
10.1101/2025.03.24.641145 — pathology — Posted on 2025-03-26
816 Spatial Transcriptomics and Single-Nucleus RNA Sequencing Reveal rAAV2- and rAAV9-Specific Transduction Signatures in the Mouse Liver
Amberg, B.; Koechl, F.; Kumpesa, N.; Prasad, M.; Bochner, F.; Hernandez-Obiols, M.; Otteneder, M. B.; Stalder, L.; Shaffo, F.; Nowrouzi, A.; Markusic, D.; Haegel, H.; Xicluna, R.; Sultan, M.; Jacobsen, B.; Rottenberg, S.; Valdeolivas, A.; Schwalie, P. C.; Hahn, K.
10.1101/2025.03.13.643011 — molecular biology — Posted on 2025-03-26
818 CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance
Buj, R.; Cole, A. R.; Danielson, J.; Xu, J.; Hurd, D.; Kishore, A.; Kedziora, K. M.; Chen, J.; Yang, B.; Barras, D.; Uboveja, A.; Amalric, A.; Apiz, J. J.; Wickramasinghe, J.; Tangudu, N. K.; Levasseur, E.; Wang, H.; Minasyan, A.; Dadey, R. E.; Sharrow, A. C.; Kunning, S.; Vendetti, F. P.; Rivadeneira, D. B.; Bakkenist, C. J.; Bruno, T. C.; Delgoffe, G. M.; Hempel, N.; Snyder, N. W.; Bao, R.; Soloff, A. C.; Kirkwood, J. M.; Dangaj Laniti, D.; Kossenkov, A. V.; Muir, A.; Das, J.; Davar, D.; Mesaros, C.; Aird, K. M.
10.1101/2025.02.08.637227 — cancer biology — Posted on 2025-03-26
819 The Microbiology Galaxy Lab: A community-driven gateway to tools, workflows, and training for reproducible and FAIR analysis of microbial data
Nasr, E.; Amato, P.; Bernt, M.; Bhardwaj, A.; Blankenberg, D.; Brites, D.; Cumbo, F.; Do, K.; Ferrari, E.; Griffin, T. J.; Gruening, B.; Hiltemann, S.; Hyde, C. J.; Jagtap, P.; Mehta, S.; Metris, K. L.; Momin, S.; Oba, A.; Pavloudi, C.; Pechlivanis, N.; Peguilhan, R.; Price, G. R.; Psomopoulos, F.; Rosic, N.; Schatz, M. C.; Schiml, V. C.; Siguret, C.; Soranzo, N.; Stubbs, A.; Van Heusden, P.; Vohra, M.; microGalaxy Community, ; Zierep, P.; Batut, B.
10.1101/2024.12.23.629682 — bioinformatics — Posted on 2025-03-26
820 A new corrector rescues F508del-CFTR folding through stabilization of the TMD1-NBD1 linker
van der Sluijs, P.; Papaioannou, O.; Hagos, A.; Saleh, A. M.; Hodges, T.; Balut, C.; Green, M.; Alani, S.; Fan, Y.; Ebine, K.; Schrimpf, M.; Hardee, D.; Li, H.-Q.; Korman, H.; Tade, L.; van Zadelhoff, G.; Singh, A.; Tse, C.; Braakman, I.
10.1101/2025.03.10.640553 — biochemistry — Posted on 2025-03-26
822 Ventral-to-dorsal electrocyte development in electric organs of electric eel (Electrophorus)
Senarat, S.; Matsumoto, A.; Nagasawa, T.; Sakaki, S.; Tsuzuki, D.; Uchida, K.; Kuwahara, M.; Nikaido, M.; Hondo, E.; Iida, A.
10.1101/2024.08.21.606117 — developmental biology — Posted on 2025-03-26
823 Turning blood to brain cells: a plasma mediated reprograming model
Arora, R.; Bhardwaj, A.; Panda, N. K.; Das, R.; Sinharay, S.; Patkulkar, P.; Gupta, T.; Bakshi, J.; Virk, R.; Nayak, G.; Patro, S. K.; Bhadada, S.; Pal, A.; Pal, R.; Chhabra, S.; Chhabra, S.; Pal, M.; Rashid, S.; SHARMA, M.
10.1101/2025.03.19.643269 — cell biology — Posted on 2025-03-26
824 Jagged1 is a Notch-independent mechanotransducer in endothelial cells
Suarez Rodriguez, F.; Virtanen, N.; Kiviluoto, E.; Driessen, R. C. H.; Zhao, F.; Bouten, C. V. C.; Stassen, O. M. J. A.; Sahlgren, C. M.
10.1101/2024.11.14.623558 — cell biology — Posted on 2025-03-26
825 Comparative wastewater virome analysis with different enrichment methods
Thornton, M.; Eder, G. M.; Amman, F.; Pantielieieva, A.; Vierheilig, J.; Bergthaler, A.
10.1101/2025.03.25.645222 — microbiology — Posted on 2025-03-26
826 Enolase-1 is essential for neutrophil recruitment during acute inflammation
Lu, H.-Y.; Huang, P.-H.; Lee, T.-W.; Chang, H.-W.; Chen, N.-Y.; Zhuang, Y.-J.; Yuan, T.-T.; Chen, C.-J.
10.1101/2024.12.26.630451 — immunology — Posted on 2025-03-26
829 MAIS: an in-vitro sandbox enables adaptive neuromodulation via scalable neural interfaces
Chen, H.; Chen, F.; Chen, X.; Liu, Y.; Xu, J.; Li, J.; Bao, X.; Chen, Y.; Sun, H.; Jiang, J.; Ye, F.; Su, J.; Gen, Y.; Ye, F.; Wang, Z.; Liu, L.; Hexige, S.; Li, X.; Ma, L.; Shuai, J.
10.1101/2025.03.15.641656 — bioengineering — Posted on 2025-03-26
830 Generalist malaria parasites and host imprinting: Unveiling transcriptional memory
Garcia-Longoria Batanete, L.; Palinauskas, V.; Azelyte, J.; Marzal, A.; Ovelleiro, D.; Hellgren, O.
10.1101/2025.03.24.644894 — genomics — Posted on 2025-03-26
831 Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P.; Schifferli, M.; Yang, K.; Burcham, T.; Cronan, P.; Glennon, O.; Jacks, O.; Laning, E.; Marrs, L.; Oba, K.; Yeung, S.; Parker, E.; Omah, I.; Pekar, J. E.; Luebbert, L.; Andersen, K. G.; Park, D. J.; Schaffner, S. F.; MacInnis, B. L.; Happi, C.; Lemieux, J. E.; Ozonoff, A.; Mitzenmacher, M. D.; Fry, B.; Sabeti, P. C.
10.1101/2025.03.25.645253 — genomics — Posted on 2025-03-26
835 Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence
Lu, J.; Rao, S. R.; Knowles, H.; Zhan, H.; Gamez, B.; Platt, E.; Frost, L. R.; Allen, T. J.; Marshall, G.; Huber, K. V. M.; Bauer, L. G.; Vendrell, I.; Kessler, B. M.; Horne, A.; Reid, I. R.; Bountra, C.; Kirkland, J. L.; Khosla, S.; Ebetino, F. H.; Roldan, E.; Russell, R. G. G.; Edwards, J. R.
10.1101/2025.03.25.645228 — cell biology — Posted on 2025-03-26
836 Snapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection
Kotova, I.; Muehlberg, L.; Gilep, K.; Yu, D.; Ziemianowicz, D.; Stanelle-Bertram, S.; Beck, S.; Baeg, K.; Duss, O.; Gabriel, G.; Liu, F.; Bogdanow, B.; Kosinski, J.
10.1101/2025.03.09.642134 — microbiology — Posted on 2025-03-26
839 Towards a species search engine: KISSE offers a rigorous statistical framework for bone collagen tandem mass spectrometry data
Gharibi, H.; Saei, A. A.; Chernobrovkin, A. L.; Lundstrom, S. L.; Lyu, H.; Meng, Z.; Vegvari, A.; Gaetani, M.; Zubarev, R. A.
10.1101/2025.03.24.641820 — zoology — Posted on 2025-03-26
842 Circular RNA profiling and functional screening in breast cancer identify circNSD1 as a suppressor of tumor autophagy
Li, W.; Yang, W.; Her, P. H.; Yang, T.; Li, T.; Huang, Z.; Xu, X.; Teng, M.; Chen, M.; Soares, F.; Liu, S.; Haibe-Kains, B.; He, H. H.; Ming, J.
10.1101/2025.03.24.645059 — cancer biology — Posted on 2025-03-26
843 Diet induced insulin resistance is due to induction of PTEN expression
Mukherjee, R.; Pancholi, P.; Sharma, M.; Solomon, H.; Timaul, M.; Thant, C.; MsGriskin, R.; Hayatt, O.; Markov, V.; D'Allara, J.; Bekker, S.; Candelier, J.; Vanaja, K.; Rosen, N.
10.1101/2025.03.25.645201 — cell biology — Posted on 2025-03-26
844 The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters
Parashara, P.; Gao, L.; Riglos, A.; Sidhu, S. B.; Lartey, D.; Marks, T.; Williams, C.; Siauw, G.; Ostrem, A. I.; Siebold, C.; Kinnebrew, M.; Riffle, M.; Gunn, T. M.; Kong, J. H.
10.1101/2025.03.25.645338 — cell biology — Posted on 2025-03-26
846 PIEZO1 Drives Trophoblast Fusion and Placental Development
Zhang, Y.; Shan, K. Z.; Liang, P.; Lowry, A. J.; Feng, L.; Yang, H.
10.1101/2025.03.25.645313 — cell biology — Posted on 2025-03-26
847 Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses
Omori, K.; Tamura, K.; Ohnishi, H.; Hasebe, K.; Fujimura, S.; Katsuno, T.; Zou, Z.; Oki, S.; Ohkawa, Y.
10.1101/2025.03.25.645195 — cell biology — Posted on 2025-03-26
848 Rejuvenated human amniotic fluid stem cells: a superior source of standardized induced mesenchymal stem cells for enhanced therapeutic applications
Corcelli, M.; Petzendorfer, E.; Vlahova, F.; Hawkins, K.; Caruso, C. A.; Hasan, M. M.; Durrant, K.; David, A.; Dijk, F. S. v.; Guillot, P. V.
10.1101/2025.03.25.645040 — cell biology — Posted on 2025-03-26
849 Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis leading to rotenone-induced G2/M Arrest
Dutta, S.; Chakraborty, S.; Ghosh, A.; Halder, P.; Majumder, S.; Paul, R.; Nath, S.; Mukherjee, P.
10.1101/2025.03.25.645152 — cell biology — Posted on 2025-03-26
851 CFTR function in alveolar type 1 cells drives lung liquid secretion and host defense
Suthakaran, S.; Homami, S.; Chavez, D.; Tang, S.; Moore, S. K. L.; Sussman, C.; Zhang, J.; Britto, C. J.; Prince, A.; May, A. J.; Kathiriya, J. J.; Hook, J. L.
10.1101/2025.03.25.645303 — cell biology — Posted on 2025-03-26
852 The Volume of Mitochondria Inherited Impacts mtDNA Homeostasis in Budding Yeast
Ray, M. W.; Chen, W.; Duan, C.; Bravo, G.; Krueger, K.; Rosario, E. M.; Jacob, A. A.; Lackner, L. L.
10.1101/2025.03.25.645216 — cell biology — Posted on 2025-03-26
854 Valorization of mushroom by-products for sustainability: exploring antioxidant and prebiotic properties
Navarro-Simarro, P.; Gomez-Gomez, L.; Rubio-Moraga, A.; Moreno-Gimenez, E.; Lopez-Jimenez, A. J.; Prieto, A.; Ahrazem, O.
10.1101/2025.03.24.644873 — molecular biology — Posted on 2025-03-26
855 Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects
Gendra, J. C.; Lopez-Sola, E.; Castaldo, F.; Lleal-Custey, E.; Sanchez-Todo, R.; Vohryzek, J.; Salvador, R.; Andrzejak, R.; Ruffini, G.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.12.15.628565 — neuroscience — Posted on 2025-03-26
856 Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage.
Scholz, P.; Dabisch, J.; Clews, A. C.; Niemeyer, P. W.; Vilchez, A. C.; Lim, M. S. S.; Sun, S.; Hembach, L.; Dreier, F.; Blersch, K.; Preuss, L.; Bonin, M.; Lesch, E.; Iwai, Y.; Shimada, T.; Eirich, J.; Finkemeier, I.; Gutbrod, K.; Doermann, P.; Wang, Y.; Mullen, R. T.; Ischebeck, T.
10.1101/2025.03.24.644787 — plant biology — Posted on 2025-03-26
857 Dysproteostasis primes pancreatic epithelial state changes in KRAS-mediated oncogenesis
Salomo-Coll, C.; di Monaco, M.; Holkham, J.; Smith, M. D.; Muir, M.; Gautier, P.; Zheng, X.; Krishnankutty, R.; Kemp, A. J.; Winnington-Ingram, K.; Von Kriegsheim, A.; Morton, J. P.; Jimenez-Moreno, N.; Mole, D. J.; Wilkinson, S.
10.1101/2025.03.24.644918 — cancer biology — Posted on 2025-03-26
858 Sustained epithelial interferon signaling modulates incomplete pathologic response in colorectal cancer
Erkan, E. P.; Hämäläinen, E.; Kolikova, J.; Kuc, K.; Ojala, K.; Kukkonen, M.; Hermelo, I.; Koskensalo, S.; Tarvainen, T.; Leppä, A.; Keränen, I.; Haapamäki, C.; Karjalainen, E.; Carpelan-Holmström, M.; Renkonen-Sinisalo, L.; Koskenvuo, L.; Puolakkainen, P.; Pekka-Mecklin, J.; Viroläinen, E.; iCAN, ; Nykter, M.; Aaltonen, L.; Lepistö, A.; Ristimäki, A.; Seppälä, T. T.
10.1101/2025.03.24.644737 — cancer biology — Posted on 2025-03-26
859 Enhanced Functional Potential of Pseudogene-associated lncRNA Genes in Mammals
Zhang, Z.-H.; Li, B.-H.; Wang, Y.-W.; Qian, S. H.; Chen, L.; Shi, M.-W.; Zuo, H.; Chen, Z.-X.
10.1101/2025.03.21.644463 — genomics — Posted on 2025-03-26
860 Annotating the genome at single-nucleotide resolution with DNA foundation models
de Almeida, B. P.; Dalla-Torre, H.; Richard, G.; Blum, C.; Hexemer, L.; Gelard, M.; Mendoza-Revilla, J.; Tang, Z.; Marin, F. I.; Emms, D. M.; Pandey, P.; Laurent, S.; Lopez, M.; Laterre, A.; Lang, M.; Sahin, U.; Beguir, K.; Pierrot, T.
10.1101/2024.03.14.584712 — genomics — Posted on 2025-03-26
864 Accurate DNA Methylation Predictor for C9orf72 Repeat Expansion Alleles in the Pathogenic Range
Ramesh, N.; Evans, A.; Wojta, K.; Yang, Z.; Boks, M. M.; Kahn, R. S.; de Boer, S. S.; van der Lee, S. J.; Pijnenburg, Y. A. L.; Reus, L. M.; Ophoff, R. A.
10.1101/2025.03.20.643775 — genetics — Posted on 2025-03-26
865 Leveraging Natural Language Processing models to decode the dark proteome across the Animal Tree of Life
Martinez-Redondo, G. I.; Perez Canales, F. M.; Fernandez Gonzalez, J. M.; Barrios-Nunez, I.; Vazquez-Valls, M.; Cases, I.; Rojas, A. M.; Fernandez, R.
10.1101/2024.02.28.582465 — evolutionary biology — Posted on 2025-03-26
866 An episodic burst of massive genomic rearrangements and the origin of non-marine annelids
Vargas-Chavez, C.; Benitez-Alvarez, L.; Martinez-Redondo, G. I.; Alvarez-Gonzalez, L.; Salces-Ortiz, J.; Eleftheriadi, K.; Escudero, N.; Guiglielmoni, N.; Flot, J.-F.; Novo, M.; Ruiz-Herrera, A.; McLysaght, A.; Fernandez, R.
10.1101/2024.05.16.594344 — evolutionary biology — Posted on 2025-03-26
867 A contribution to the anatomy of two rare cetacean species: the hourglass dolphin (Lagenorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica)
Graic, J.-M.; Gerussi, T.; Cozzi, B.; Boys, R. M.; Kot, B. C. W.; Perrott, M.; Fleury, K.; Chung, T. Y. T.; Tsui, H. C. L.; Burns, E.; Webster, T.; Hunter, S.; Betty, E.; Howarth, O.; Loch, C.; White, S.; Dawson, S.; Rayment, W.; Cole, R.; Cox, D.; Waterhouse, T.; Hendriks, H.; van Helden, A.; Johnstone, M.; Stewart, R. O.; Fordyce, R. E.; Stockin, K. A.
10.1101/2024.11.06.622215 — evolutionary biology — Posted on 2025-03-26
872 In vivo reconstruction of Duvernoy's postmortem vasculature images
Gulban, O. F.; Stirnberg, R.; Tse, D. H. Y.; Pizzuti, A.; Koiso, K.; Archila-Melendez, M. E.; Huber, R.; Bollmann, S.; Kay, K.; Ivanov, D.
10.1101/2025.03.23.644588 — neuroscience — Posted on 2025-03-26
873 Temporal fMRI Dynamics Map Dopamine Physiology
Ballard, I.; Pappas, I.; Furman, D. J.; Berry, A. S.; Frederick, B. d.; White, R. L.; Kayser, A. S.; Jagust, W. J.; D'Esposito, M.
10.1101/2025.03.24.645022 — neuroscience — Posted on 2025-03-26
877 Diurnal Regulation of Urinary Behavior and Gene Expression in Aged Mice
Taylor, D. S.; Allotey, A. A.; Fanelli, R. E.; Satyanarayana, S. B.; Bettadapura, S. S.; Wyatt, C. R.; Landen, J.; Nelson, A. C.; Schmitt, E. E.; Bruns, D. R.; Bedford, N. L.
10.1101/2025.03.16.642675 — physiology — Posted on 2025-03-26
878 RRIkinDP: Targeted RNA-RNA interaction kinetics
Waldl, M.; Beckmann, I. K.; Will, S.; Hofacker, I. L.
10.1101/2023.07.28.548983 — bioinformatics — Posted on 2025-03-26
879 Generation of antigen-specific paired chain antibody sequences using large language models
Wasdin, P. T.; Johnson, N. V.; Janke, A. K.; Held, S.; Marinov, T. M.; Jordaan, G.; Vandenabeele, L.; Pantouli, F.; Gillespie, R. A.; Vukovich, M. J.; Holt, C. M.; Kim, J.; Hansman, G.; Logue, J.; Chu, H. Y.; Andrews, S. F.; Kanekiyo, M.; Sautto, G. A.; Ross, T. M.; Sheward, D. J.; McLellan, J. S.; Abu-Shmais, A. A.; Georgiev, I. S.
10.1101/2024.12.20.629482 — bioinformatics — Posted on 2025-03-26
882 MAGNETICALLY STEERED CELL THERAPY FOR REDUCTION OF INTRAOCULAR PRESSURE AS A TREATMENT STRATEGY FOR OPEN-ANGLE GLAUCOMA
Bahrani Fard, M. R.; Chan, J.; Read, A. T.; Li, G.; Cheng, L.; N Safa, B.; Siadat, S. M.; Jhunjhunwala, A.; Grossniklaus, H. E.; Emelianov, S. Y.; Stamer, W. D.; Kuehn, M. H.; Ethier, C. R.
10.1101/2024.05.13.593917 — bioengineering — Posted on 2025-03-26
883 Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1
Rai, R.; Dawodu, O.; Meng, J.; Johnson, S. M.; Vilseck, J. Z.; Kelley, M. R.; Ziarek, J. J.; Georgiadis, M. M.
10.1101/2023.06.29.547112 — biochemistry — Posted on 2025-03-26
884 VUStruct: a compute pipeline for high throughput and personalized structural biology
Moth, C. W.; Sheehan, J. H.; Mamun, A. A.; Sivley, R. M.; Gulsevin, A.; Rinker, D.; Capra, J. A.; Meiler, J.; Undiagnosed Diseases Network,
10.1101/2024.08.06.606224 — biochemistry — Posted on 2025-03-26
886 A single high-zinc activation enhancer can control two genes oriented head-to-head in C. elegans
Liu, H.; Earley, B.; Mendoza, A.; Hunt, P.; Teng, S.; Schneider, D. L.; Kornfeld, K.
10.1101/2024.11.19.624376 — genetics — Posted on 2025-03-26
887 Expression divergence in response to sex-biased selection
Grieshop, K.; Liu, M. J.; Frost, R. S.; Lindsay, M. P.; Bayoumi, M.; Brengdahl, M. I.; Molnar, R. I.; Agrawal, A. F.
10.1101/2024.11.11.622976 — evolutionary biology — Posted on 2025-03-26
890 Generative frame interpolation enhances tracking of biological objects in time-lapse microscopy
Kaondal, S.; Taassob, A.; Jeon, S.; Lee, S. H.; Nunez, H. L.; Akindipe, B. A.; Lee, H.; Joo, S. Y.; Oliveira, S. M. D.; Arguello-Miranda, O.
10.1101/2025.03.23.644838 — cell biology — Posted on 2025-03-26
891 Weberviruses are gut-associated phages that infect Klebsiella spp.
Dawson, S. J.; Shibu, P.; Garnett, S.; Newberry, F.; Brook, T. C.; Tijani, T.; Kujawska, M.; Hall, L. J.; McCartney, A. L.; Negus, D.; Hoyles, L.
10.1101/2024.11.04.620279 — microbiology — Posted on 2025-03-26
897 Structure of the turnip yellows virus particles.
Lai-Kee-Him, J.; Trapani, S.; Boissinot, S.; Reinbold, C.; Fallet, C.; Ancelin, A.; Lecorre, F.; Hoh, F.; Ziegler-Graff, V.; Brault, V.; Bron, P.
10.1101/2024.10.14.617924 — microbiology — Posted on 2025-03-25
898 Magnetized Cellbots to Spatiotemporally Control Differentiation of Human-Induced Pluripotent Stem Cells
Mohanty, R. P.; Mallick, S.; Crowley, P.; Sokolich, M.; Kiwimagi, K.; Razavi, S.; Belta, C.; Das, S.; Weiss, R.
10.1101/2025.03.24.645121 — synthetic biology — Posted on 2025-03-25
899 Imaging throughput of compact handheld microscopes for quantitative single cell studies
BULLOCH, S.; XU, T.; HERRMANN, D.; TIMPSON, P.; PHAN, T. G.; Lim, Y. J.; Lee, W. M.
10.1101/2025.03.24.645046 — biophysics — Posted on 2025-03-25
903 Annotating the genome at single-nucleotide resolution with DNA foundation models
de Almeida, B. P.; Dalla-Torre, H.; Richard, G.; Blum, C.; Hexemer, L.; Gelard, M.; Mendoza-Revilla, J.; Tang, Z.; Marin, F. I.; Emms, D. M.; Pandey, P.; Laurent, S.; Lopez, M.; Laterre, A.; Lang, M.; Sahin, U.; Beguir, K.; Pierrot, T.
10.1101/2024.03.14.584712 — genomics — Posted on 2025-03-25
904 Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury
Upadhyay, V.; Ortega, E. F.; Hernandez, L. A. R.; Alexander, M.; Kaur, G.; Trepka, K.; Rock, R. R.; Shima, R. T.; Cheshire, W. C.; Alipanah-Lechner, N.; Calfee, C. S.; Matthay, M. A.; Lee, J. V.; Goga, A.; Jain, I.; Turnbaugh, P. J.
10.1101/2025.03.24.645052 — molecular biology — Posted on 2025-03-25
905 Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis
Gawish, R.; Varada, R.; Deckert, F.; Hladik, A.; Steinbichl, L.; Cimatti, L.; Milanovic, K.; Jain, M.; Torgasheva, N.; Tanzer, A.; De Paepe, K.; VandWiele, T.; Hausmann, B.; Lang, M.; Pechhacker, M.; Ibrahim, N.; DeVries, I.; Brostjan, C.; Sixt, M.; Gasche, C.; Boon, L.; Berry, D.; Jantsch, M.; Pereira, F. C.; Vesely, C.
10.1101/2025.03.25.643676 — molecular biology — Posted on 2025-03-25
906 Rsc1 DNA-binding bromodomain drives RSC activity at A-rich promoters
Sayou, C.; Viravaux, O.; Lyonnet, J.; Lucas, J.; Dupeyron, R.; Thevenon, E.; Marais, J.; Adrait, A.; Coute, Y.; Parcy, F.; Petosa, C.; Govin, J.
10.1101/2025.03.24.644971 — molecular biology — Posted on 2025-03-25
907 Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase
Tang, S.; Zedaveinyte, R.; Burman, N.; Pandey, S.; Ramirez, J. L.; Kulber, L. M.; Wiegand, T.; Wilkinson, R. A.; Ma, Y.; Zhang, D. J.; Lampe, G. D.; Berisa, M.; Jovanovic, M.; Wiedenheft, B.; Sternberg, S. H.
10.1101/2025.03.24.645077 — molecular biology — Posted on 2025-03-25
908 SIRT2 protects against Japanese encephalitis virus infection in mice
Desingu, P. A.; Dindi, L.; Murugasamy, K.; Tamta, A. K.; Ramasubbu, V.; Raghu, S.; Shrama, A.; Rajmani, R. S.; Sundaresan, N. R.
10.1101/2025.03.24.645101 — microbiology — Posted on 2025-03-25
909 Short-term alterations in dietary amino acids override host genetic susceptibility and reveal mechanisms of Salmonella Typhimurium small intestine colonization
Shealy, N.; Baltagulov, M.; de Brito, C.; McGovern, A.; Castro, P.; Schrimpe-Rutledge, A. C.; Malekshahi, C.; Condreanu, S. G.; Sherrod, S. D.; Jana, S.; Jones, K.; Machado Ribeiro, T. R.; McLean, J.; Beiting, D. P.; Byndloss, M. X.
10.1101/2025.03.25.645332 — microbiology — Posted on 2025-03-25
911 Lognormal distributions capture site-specific variability in enteric virus concentrations in wastewater
Li, C.; Kohn, T.; Torii, S.; Wynn, H. K.; Devaux, A. J.; Gan, C.; Julian, T. R.; Sylvestre, E.
10.1101/2025.03.25.645242 — microbiology — Posted on 2025-03-25
912 In vitro and in vivo synergy of Vancomycin and β-lactams against drug-resistant Mycobacterium tuberculosis and Non-tuberculous mycobacteria
SINGH, A. K.; Pradip, M.; Mukhopadhyay, A.; Imran, M.; Ahmad, M. N.; Ali, J.; Pramanik, S.; Maindolia, R.; Ghosh, A.; Karaulia, P.; Gupta, U. D.; Mitra, K.; Chopra, S.; Dasgupta, A.
10.1101/2025.03.24.644967 — microbiology — Posted on 2025-03-25
913 OCA-B promotes pathogenic maturation 1 of stem-like CD4+ T cells and autoimmune demyelination
Hughes, E. P.; Syage, A. R.; Mehrabad, E. M.; Lane, T. E.; Spike, B. T.; Tantin, D.
10.1101/2023.11.29.569210 — immunology — Posted on 2025-03-25
914 Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics
Muralidharan, C.; Zakar-Polyak, E.; Adami, A.; Abbas, A. A.; Sharma, Y.; Garza, R.; Johansson, J. G.; Atacho, D. A. M.; Renner, E.; Palkovits, M.; Kerepesi, C.; Jakobsson, J.; Pircs, K.
10.1101/2025.02.28.640749 — neuroscience — Posted on 2025-03-25
916 Suspended Tissue Open Microfluidic Patterning (STOMP)
Haack, A. J.; Brown, L. G.; Goldstein, A. J.; Mulimani, P.; Berthier, J.; Viswanathan, A. R.; Kopyeva, I.; Whitten, J. M.; Lin, A.; Nguyen, S. H.; Leahy, T. P.; Bouker, E. E.; Padgett, R. M.; Mazzawi, N. A.; Tokihiro, J. C.; Bretherton, R. C.; Wu, A.; Tapscott, S. J.; DeForest, C. A.; Popowics, T. E.; Berthier, E.; Sniadecki, N. J.; Theberge, A. B.
10.1101/2024.10.04.616662 — bioengineering — Posted on 2025-03-25
917 Evolved microbial diversity enables combinatoric biosensing in complex environments
Chiang, A. J.; Csicsery, N.; O'Laughlin, R.; Baumgart, L.; Stasiowski, E.; Nguyen, P.; Doughty, A.; Ashraf, M.; Mink, R.; Olson, E. C.; Ferry, M.; Feist, A. M.; Hao, N.; Zengler, K.; Hasty, J.
10.1101/2025.03.24.645055 — bioengineering — Posted on 2025-03-25
921 MyoRep: a novel reporter system to detect early muscle atrophy in vitro and in vivo
Re Cecconi, A. D.; Rizzi, N.; Barone, M.; Palo, F.; Lunardi, M.; Forti, M.; Maggi, A.; Ciana, P.; Terribile, G.; Chiappa, M.; Zentilin, L.; Piccirillo, R.
10.1101/2025.02.27.640021 — genetics — Posted on 2025-03-25
923 Cross-subgenus hybridization between Leishmania and Sauroleishmania informs on parasite genomic compatibility and transcriptomic adaptation
Louzada-Flores, V. N.; Pescher, P.; Cokelaer, T.; Rodrigues Ferreira, T.; Latrofa, M. S.; Mendoza-Roldan, J. A.; Otranto, D.; Späth, G. F.; Louradour, I.
10.1101/2025.03.25.645178 — microbiology — Posted on 2025-03-25
925 PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes
Seager, B. A.; LIm, P. S.; Lai, K. H.; Feufack-Donfack, L. B.; Dass, S.; Xiao, X.; Jung, N. C.; Abraham, A.; Grigg, M. J.; Anstey, N. M.; William, T.; Sattabongkot, J.; Leis, A.; Longley, R. J.; Duraisingh, M. J.; Popovici, J.; Wilson, D.; Scally, S. W.; Cowman, A. F.
10.1101/2025.03.25.644866 — microbiology — Posted on 2025-03-25
926 Statistical end-to-end analysis of large-scale microbial growth data with DGrowthR
Feldl, M.; Olayo-Alarcon, R.; Amstalden, M. K.; Zannoni, A.; Peschel, S.; Sharma, C. M.; Brochado, A. R.; Müller, C. L.
10.1101/2025.03.25.645164 — microbiology — Posted on 2025-03-25
927 Limited value of Nanopore adaptive sampling in a long-read metagenomic profiling workflow of clinical sputum samples
Xu, W.; Top, J.; Viveen, M. C.; Slyzkyi, A.; Hermans, N.; van Erp, S.; Eiloz, D.; Anthony, R.; Kremer, K.; Schürch, A. C.
10.1101/2025.03.25.645176 — microbiology — Posted on 2025-03-25
930 Fructose malabsorption induces dysbiosis and increases anxiety in Human and animal models
Coursan, A.; Polve, D.; Leroi, A.-M.; Monnoye, M.; Roussin, L.; Tavolacci, M.-P.; Quillard Muraine, M.; Maccarone, M.; Guerin, O.; Houivet, E.; Guerin, C.; Brunel, V.; Bellenger, J.; De-Barros, J.-P. P.; Gourcerol, G.; Naudon, L.; Laye, S.; Madore, C.; Fioramonti, X.; Melchior, C.; Douard, V.
10.1101/2025.03.25.645339 — microbiology — Posted on 2025-03-25
931 EnvZ signal output correlates with capacity for transmembrane water encapsulation
Yusuf, R.; Yau, J. J. Y.; Baker-Valla, G. W.; Lawrence, R. J.; Draheim, R. R.
10.1101/2025.03.25.645265 — microbiology — Posted on 2025-03-25
932 The cellular and behavioral blueprints of chordate rheotaxis.
Tolstenkov, O.; Ozawa, A.; Allombert-Blaise, C.; Hoyer, J.; Hiraiwa, T.; Chatzigeorgiou, M.
10.1101/2025.03.22.644710 — neuroscience — Posted on 2025-03-25
933 Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases
Jensen, N. M.; Vitic, Z.; Antorini, M. R.; Bruun Viftrup, T.; Parkkinen, L.; Jensen, P. H.
10.1101/2024.12.20.629583 — neuroscience — Posted on 2025-03-25
934 Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC
Zhu, Q.; Balasubramanian, A.; Asirvatham, J. R.; Chatterjee, M.; Piyarathna, D. W. B.; Kaur, J.; Mohamed, N.; Wu, L.; Wang, S.; Pourfarrokh, N.; Binsol, P. D.; Bhargava, M.; Rasaily, U.; Xu, Y.; Zheng, J.; Jebakumar, D.; Rao, A.; Gutierrez, C.; Omilian, A.; Morrison, C.; Das, G. M.; Ambrosone, C.; Seeley, E. H.; Chen, S.-h.; Li, Y.; Chang, E.; Li, X.; Baker, E.; Aneja, R.; Zhang, X. H.- F.; Sreekumar, A.
10.1101/2024.03.17.585428 — cancer biology — Posted on 2025-03-25
935 Towards a Biohybrid Lung? Impacted Endothelial Layer Integrity in Inflammatory Conditions
Cheremkhina, M.; Babendreyer, A.; Neullens, C. T.; Krapp, S.; Pabst, A.; Ohl, K.; Ruetten, S.; Ludwig, A.; Cornelissen, C. G.; Jockenhoevel, S.; Tenbrock, K.; Thiebes, A. L.
10.1101/2023.10.31.564901 — bioengineering — Posted on 2025-03-25
936 Control of physical and biochemical parameters influencing exogeneous cargo protein association to extracellular vesicles using lipid anchors enables high loading and effective intracellular delivery
Marquant, A.; Berthelot, J.; Bich, C.; Ibn Elfekih, Z.; Simon, L.; Robin, B.; Chopineau, J.; Tianpei Wang, D.; Jay Emerson, S.; Wang, A.; Benedetti, C.; Langlois, S.; Guglielmi, L.; Martineau, P.; Aubert-Pouessel, A.; Morille, M.
10.1101/2024.08.28.610030 — bioengineering — Posted on 2025-03-25
938 Repeated evolution of supergenes on an ancient social chromosome
Lajmi, A.; Cohen, P.; Lee, C.-C.; Frenkel, Z.; Pellen, Y.; Privman, E.
10.1101/2024.12.01.626239 — evolutionary biology — Posted on 2025-03-25
941 Bird population trend analyses for a monitoring scheme with a highly structured sampling design
Rieger, M. R.; Grueneberg, C.; Oberhaus, M.; Trautmann, S.; Parepa, M.; Anthes, N.
10.1101/2024.06.30.601382 — ecology — Posted on 2025-03-25
942 Optogenetic control of pheromone gradients and mating behavior in budding yeast
Banderas, A.; Hofmann, M.; Cordier, C.; Le Bec, M.; Elizondo, C.; Chiron, L.; Pouzet, S.; lifschytz, y.; Ji, W.; Amir, A.; Scolari, V.; Hersen, P.
10.1101/2024.02.06.578657 — cell biology — Posted on 2025-03-25
943 Deficiency of mitophagy mediator Parkin in aortic smooth muscle cells exacerbates abdominal aortic aneurysm
Wang, H.; Kazaleh, M.; Gioscia-Ryan, R. A.; Millar, J.; Temprano-Sagrera, G.; Wood, S.; Van Den Burgh, F.; Blin, M. G.; Wragg, K. M.; Luna, A.; Hawkins, R. B.; Soleimanpour, S. A.; Sabater-Lleal, M.; Shu, C.; Beard, D. A.; Ailawadi, G.; Deng, J. C.; Goldstein, D. R.; Salmon, M.
10.1101/2024.10.30.621201 — molecular biology — Posted on 2025-03-25
944 Grapevine holobiome metatranscriptomics provides a glimpse into the wood mycovirome
Debat, H. J.; Paolinelli, M.; Escoriaza, G.; Garcia Lampasona, S.; Gomez Talquenca, S.; Bejerman, N.
10.1101/2025.03.21.644598 — microbiology — Posted on 2025-03-25
945 MAPPING CHANGES OF MIRNA-MRNA NETWORKS IN LEISHMANIA-INFECTED MACROPHAGES PREDICTS REGULATORY MIRNA-TF LOOPS AS NOVEL TARGETS OF PARASITE IMMUNE SUBVERSION
Gharsallah, C.; Lecoeur, H.; Varet, H.; Legendre, R.; Sismeiro, O.; Coppee, J.-Y.; Proux, C.; Scarfiello, E.; Bruckmann, A.; Meister, G.; Prina, E.; Spaeth, G. F.
10.1101/2024.03.24.586456 — microbiology — Posted on 2025-03-25
946 The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke
Li, T.; Yang, L.; Tu, J.; Hao, Y.; Zhu, Z.; Xiong, Y.; Gao, Q.; Zhou, L.; Xie, G.; Zhang, D.; Li, X.; Jin, Y.; Zhang, Y.; Zhao, B.; Li, N.; Wang, X.; Jia, J.-M.
10.1101/2023.12.07.570712 — neuroscience — Posted on 2025-03-25
948 Role of N-glycosylation as a determinant of ATG9A conformations and activity
Lambrughi, M.; Utichi, M.; Borg, C. B.; Marjault, H.-B.; Echeverria, S. E.; Maeda, K.; Taylor, N. M. I.; Fadda, E.; Jaattela, M.; Papaleo, E.
10.1101/2025.01.17.633517 — biophysics — Posted on 2025-03-25
949 Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex
Johansen, N. J.; Kempynck, N.; Zemke, N. R.; Somasundaram, S.; Winter, S. D.; Hooper, M.; Dwivedi, D.; Lohia, R.; Wehbe, F.; Li, B.; Abaffyova, D.; Armand, E. J.; Man, J. D.; Eksi, E. C.; Hecker, N.; Hulselmans, G.; Konstantakos, V.; Mauduit, D.; Mich, J. K.; Partel, G.; Daigle, T. L.; Levi, B. P.; Zhang, K.; Tanaka, Y.; Gillis, J.; Ting, J. T.; Ben-Simon, Y.; Miller, J.; Ecker, J. R.; Ren, B.; Aerts, S.; Lein, E. S.; Tasic, B.; Bakken, T. E.
10.1101/2024.08.21.609075 — genomics — Posted on 2025-03-25
950 Decoding human placental cellular and molecular responses to maternal obesity and fetal growth
Jiang, H.; Derisoud, E.; Parreira, D.; Taebnia, N.; Jannig, P. R.; Shafagh, R. Z.; Zhao, A.; Li, C.; Ortiz, M.; Maliqueo, M. A.; Stener-Victorin, E.; Lauschke, V. M.; Deng, Q.
10.1101/2025.01.27.634981 — developmental biology — Posted on 2025-03-25
951 Frequency-Specific Resting-State MEG Network Characteristics of Tinnitus Patients Revealed by Graph Learning
Sadeghi Shabestari, P.; Behjat, H. H.; Van De Ville, D.; Cederroth, C. R.; Edvall, N. K.; Naas, A.; Kleinjung, T.; Neff, P.
10.1101/2025.03.10.642147 — neuroscience — Posted on 2025-03-25
952 Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field fMRI
Flanagan, L.; Mansur, B. d. M.; Reichert, C.; Richter, A.; Golbabaei, S.; Kizilirmak, J. M.; Sweeney-Reed, C. M.
10.1101/2024.02.14.580346 — neuroscience — Posted on 2025-03-25
953 Leveraging Sparse Annotations for Leukemia Diagnosis on the Large Leukemia Dataset
Rehman, A.; Meraj, T.; Minhas, A. M.; Imran, A.; Ali, M.; Sultani, W.; Shah, M.
10.1101/2024.11.28.625918 — pathology — Posted on 2025-03-25
954 Decreased hippocampal neurite density in middle-aged/aging adults following prenatal exposure to higher levels of maternal inflammation
Mohyee, R. A.; Elliott, B. L.; Pike, M. R.; Smith, E.; Kring, A. M.; Olson, I. R.; Breen, E. C.; Cohn, B. A.; Cirillo, P. M.; Krigbaum, N. Y.; Olino, T. M.; D'Esposito, M.; Cogan, A. B.; Patwardan, B. P.; Ellman, L. M.
10.1101/2024.10.01.616156 — immunology — Posted on 2025-03-25
955 Interfacial vortex recapture enhances thrust in tiny water skaters
Rohilla, P.; O'Neil, J. N.; Singh, P.; Ortega-Jimenez, V. M.; Choi, D.; Bose, C.; Bhamla, M. S.
10.1101/2024.06.17.599397 — biophysics — Posted on 2025-03-25
957 Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins
Pullin, J.; Rodriguez-Celma, J.; Franceschetti, M.; Mundy, J. E.; Svistunenko, D. A.; Bradley, J. M.; le Brun, N. E.; Balk, J.
10.1101/2024.10.23.619806 — biochemistry — Posted on 2025-03-25
958 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.
Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devasri, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J.; Skeath, J.; Lacin, H.
10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-03-25
961 Healing of ischemic injury in the retina
Becker, S.; Allen, J.; L'Ecuyer Morison, Z.; Saeid, S.; Adderley, A.; Koskelainen, A.; Vinberg, F.
10.1101/2024.11.04.621932 — neuroscience — Posted on 2025-03-25
962 Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer's disease
Abuwarda, H.; Trainer, A.; Horien, C.; Shen, X.; Ju, S.; Constable, T.; Fredericks, C.
10.1101/2024.04.02.587791 — neuroscience — Posted on 2025-03-25
969 Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter
Kothlow, K.; Schramm, H. M.; Markuson, K. A.; Russell, J. H.; Sutherland, E.; Veth, T. S.; Zhang, R.; Duboff, A. G.; Tejus, V. R.; McDermott, L. E.; Draeger, L. S.; Riley, N. M.
10.1101/2025.03.24.645139 — bioinformatics — Posted on 2025-03-25
970 PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
Zhao, Z.; Xu, W.; Feng, E. Y.; Cao, S.; Hermoso-Lopez, A.; Pena-Vega, P.; Lloyd, H. C.; Porter, A. K. D.; Guzman, M.; Zheng, N.; Woo, C. M.
10.1101/2025.03.24.645050 — biochemistry — Posted on 2025-03-25
972 A Novel Approach to Combat Pseudomonas aeruginosa: Repurposing Pharmaceuticals for Inhibition of Phospholipase A
Modric, M.; Gentile, R.; Schroder, L.; Moll, R.; Alio, I.; Streit, W. R.; Jaeger, K.-E.; Gohlke, H.; Kovacic, F.
10.1101/2025.03.23.644859 — molecular biology — Posted on 2025-03-25
977 Human Fcγ-receptors selectively respond to C-reactive protein (CRP) isoforms
Henning, A.; Seer, J.; Zeller, J.; Peter, K.; Thome, J.; Kolb, P.; Eisenhardt, S. U.; Hoffmann, K.; Hengel, H.
10.1101/2025.03.23.644781 — immunology — Posted on 2025-03-25
978 Astrocyte Ca2+ activity regulates node of Ranvier length in the white matter
Lezmy, J.; Quintela-Lopez, T.; Woermann, N.; Mao, S.; Thompson, C.; Attwell, D.
10.1101/2025.01.17.633566 — neuroscience — Posted on 2025-03-25
981 Canalization of flower production across thermal environments requires Florigen and CLAVATA signaling.
Smith, E. S.; John, A.; Willoughby, A. C.; Jones, D. S.; Galvao, V. C.; Fankhauser, C.; Nimchuk, Z. L.
10.1101/2025.03.23.644808 — plant biology — Posted on 2025-03-25
983 Pharmacological inhibition of mitochondrial fission mitigates experimental thoracic aortic aneurysm
Jadli, A. S.; Gomes, K. P.; Meechem, M.; Mackay, C.; Ballasy, N. N.; Belke, D. D.; Fedak, P. W.; Patel, V. B.
10.1101/2025.03.23.644843 — physiology — Posted on 2025-03-25
984 Multi-omic Evaluations Nominate an ER-Mitochondrial Axis and Inflammatory Macrophage as Drivers of Right Atrial Dysfunction
Mendelson, J. B.; Sternbach, J. D.; Blake, J. C.; Kim, M.; Moon, R. A.; Raveendran, R. M.; Hartweck, L. M.; Tollison, W.; Lahti, M.; Carney, J.; Markowski, T.; Higgins, L.; Lewandowski, C.; Kazmirczak, F.; Choudhary, G.; Prins, K.
10.1101/2025.03.22.644722 — physiology — Posted on 2025-03-25
987 Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
Lazimi, C. S.; Stis, A. E.; Panzer, J. K.; Hiller, H.; Beery, M. L.; Linnemann, A. K.; Stabler, C. L.; Mathews, C. E.; Phelps, E. A.
10.1101/2025.03.21.644659 — physiology — Posted on 2025-03-25
988 Screening for pro-adhesive compounds and their relevance as therapeutic approach in Arrhythmogenic Cardiomyopathy
Hanns, P.; Colpaert, R. M. W.; Castellanos-Martinez, R.; Weidner, F.; Beensen, S.; Matthias, F.; Xu, L.; Kuster, G. M.; Schinner, C.
10.1101/2025.03.23.643549 — pathology — Posted on 2025-03-25
989 X-Linked Cancer-Associated Polypeptide (XCP) from lncRNA1456 Cooperates with PHF8 to Regulate Gene Expression and Cellular Pathways in Breast Cancer
Gadad, S.; Camacho, C. V.; Gong, X.; Thornton, M.; Malladi, V. S.; Nagari, A.; Sundaresan, A.; Nandu, T.; Koul, S.; Peng, Y.; Kraus, W. L.
10.1101/2025.03.21.644649 — cancer biology — Posted on 2025-03-25
990 Mapping Tumor Microenvironment and Treatment Response of Diffuse Midline Glioma Using Multiplexed Immunofluorescence and AI Models
Laternser, S.; De Micheli, A. J.; Brueningk, S.; McDonough, E.; Petrovic, A.; Rushing, E. J.; Surrette, C.; Bugajska, J.; Eze, A.; Kilburn, L.; Machado, L.; Dettwiler, S.; Prutek, F.; Lagar, N. C.; de la Nava, D.; Morinigo, D.; Ginty, F.; Dun, M. D.; Grotzer, M.; Stuecklin, A. S. G.; Mueller, S.; Packer, R.; Bornhorst, M.; Alonso, M. M.; Nazarian, J.
10.1101/2025.03.23.644698 — cancer biology — Posted on 2025-03-25
991 U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations
Walter, D. M.; Cho, K.; Sivakumar, S.; Lee, I. T.- H.; Dohlman, A. B.; Shurberg, E.; Jiang, K. X.; Gupta, A. A.; Frampton, G. M.; Meyerson, M.
10.1101/2025.03.21.644128 — cancer biology — Posted on 2025-03-25
993 Molecular and cellular features of nerve-invaded cancer cells using a newly characterized experimental model
Joseph, N.; Shrestha, S.; Sassmannshausen, I.; Mizkus, S.; Chumala, P.; Sivakumar, B.; Baiju, V.; Ahmed, S.; Rees, H.; Katselis, G.; Krishnan, A.
10.1101/2025.03.21.644644 — cancer biology — Posted on 2025-03-25
995 Decoding Brain Interstitial Transport In Vivo: A Fully Validated Bottom-Up Mechanistic Prediction Framework
Yuan, T.; Pecco, N.; Zhan, W.; Galvan, S.; Secoli, R.; Riva, M.; Bello, L.; Falini, A.; Rodriguez y Baena, F.; Castellano, A.; Dini, D.
10.1101/2025.03.22.643151 — biophysics — Posted on 2025-03-25
996 Theory of multiscale epithelial mechanics under stretch: from active gels to vertex models
Ouzeri, A.; Kale, S.; Chahare, N.; Torres-Sanchez, A.; Santos, D.; Trepat, X.; Arroyo, M.
10.1101/2025.03.23.644792 — biophysics — Posted on 2025-03-25
997 SuperMetal: A Generative AI Framework for Rapid and Precise Metal Ion Location Prediction in Proteins
Lin, X.; Su, Z.; Liu, Y.; Liu, J.; Kuang, X.; Cummings, P. T.; Spencer-Smith, J.; Meiler, J.
10.1101/2025.03.21.644685 — bioinformatics — Posted on 2025-03-25
999 Explainable machine learning identifies features and thresholds predictive of immunotherapy response
Tran, K. A.; Addala, V.; Koufariotis, L. T.; Zhang, J.; Wood, S.; Leonard, C.; Hoeijmakers, L. L.; Blank, C. U.; Crispin-Ortuzar, M.; Williams, E. D.; Kondrashova, O.; Pearson, J. V.; Waddell, N.
10.1101/2025.03.23.643560 — bioinformatics — Posted on 2025-03-25
1003 Quantifying brain-wide cerebrospinal fluid flow dynamics using slow-flow-sensitized phase-contrast MRI
Dong, Z.; Wang, F.; Strom, A.; Eckstein, K.; Bachrata, B.; Robinson, S. D.; Rosen, B. R.; Wald, L. L.; Lewis, L. D.; Polimeni, J. R.
10.1101/2025.03.22.644745 — bioengineering — Posted on 2025-03-25
1006 Enhanced Functional Potential of Pseudogene-associated lncRNA Genes in Mammals
Zhang, Z.-H.; Li, B.-H.; Wang, Y.-W.; Qian, S. H.; Zuo, H.; Chen, L.; Shi, M.-W.; Chen, Z.-X.
10.1101/2025.03.21.644463 — genomics — Posted on 2025-03-25
1007 The Cistrome Response to Hypoxia in Human Umbilical Vein Endothelial Cells
Singh, A.; Pastukh, V. M.; Roberts, J. T.; Turpin, Z. M.; Glover, Z. S.; Daly, G. T.; Benoit, J. M.; Gillespie, M. N.; Bass, H. W.
10.1101/2025.03.23.644824 — genomics — Posted on 2025-03-25
1010 Selection-free CRISPR-Cas9 editing protocol for distant Dictyostelid species
Garriga-Canut, M.; Cannon, N.; Benton, M.; Zanon, A.; Horsfield, S. T.; Scheurich, J.; Remans, K.; Lees, J.; Paix, A.; van Gestel, J.
10.1101/2025.03.23.644600 — genetics — Posted on 2025-03-25
1012 Exposing the core genetic drivers of chronological aging in yeast cells
Cruz-Bonilla, E.; Campos, S. E.; Funes, S.; Abreu-Goodger, C.; DeLuna, A.
10.1101/2025.03.23.644847 — genetics — Posted on 2025-03-25
1018 Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Alonso, S.; Kaur, H.; Jia, L.; Nguyen, M.-U.; Fong, A.; Skariah, N.; Argüello, R. J.; Verzi, M. P.; Swamy, M.; Lau, K. S.; Edelblum, K. L.
10.1101/2025.03.22.644616 — immunology — Posted on 2025-03-25
1019 Targeting CXCR4-expressing TAMs in muscle-invasive bladder cancer to enhance tumor control after immunotherapy
Despond, E.; El Ahanidi, H.; Alouche, N.; Zdimerova, H.; Favre, S.; Zanette, G.; Nassiri, S.; Benamran, D.; Tsantoulis, P.; Attaleb, M.; Maby El Hajjami, H.; Dagher, J.; Gourhand, V.; Balabanian, k.; Espeli, M.; Luther, S. A.; Jandus, C.; Leblond, M. M.; Verdeil, G.
10.1101/2025.03.21.644543 — immunology — Posted on 2025-03-25
1024 Deletion of Nudt19 Increases Albuminuria in Mice Fed a High Fat Diet
Saporito, D. C.; King, R. D.; Vickers, S. D.; Wyda, E. A.; Balaji, S.; King, J. A.; Leonardi, R.
10.1101/2025.03.22.644727 — physiology — Posted on 2025-03-25
1025 The absence of collagen VI reduces systolic function but paradoxically increases Ca2+ release in the rat heart
Krstic, A.; Hassan, S.; Moammer, H.; Bai, J.; Kallingappa, P.; Hou, Y.; Annandale, M.; Mellor, K. M.; Ward, M.-L.; Barrett, C. J.; Crossman, D. J.
10.1101/2025.03.21.644665 — physiology — Posted on 2025-03-25
1026 Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategies
Russo, E.; Rezayof, A.; Wallace, C. W.; Williams, E. Q.; Beerepoot, P.; Milenkovic, M.; Novalen, M.; Blundell, A.; Lipina, T. V.; Locke, J.; Christian, R.; Finnie, P. S. B.; Edgar, L. J.; Tyndale, R.; Watkins-Chow, D. E.; Ramsey, A. J.; Jones, S. R.; Salahpour, A.
10.1101/2025.03.21.644417 — pharmacology and toxicology — Posted on 2025-03-25
1028 Nocturnal intraocular pressure rise is regulated by norepinephrine via RHOB
Ikegami, K.; Takahashi, T.; Oishi, A.; Yoshimi, A.; Nagase, M.; Miki, A.; Yasuo, S.; Masubuchi, S.
10.1101/2025.03.21.644679 — pathology — Posted on 2025-03-25
1030 Combined inhibition of NAD synthesis and C-terminal binding protein cooperatively induce cell death and inhibit growth of High Grade Serous Ovarian Carcinoma
Chougoni, K. K.; West, J.; Martin, N. S.; Dcona, D.; Kose, I.; Kim, N.; Dcona, M. M.; Drapkin, R.; Carlson, J. W.; Walts, A. E.; Orsulic, S.; Ellis, K. C.; Grossman, S. R.
10.1101/2025.03.22.643181 — cancer biology — Posted on 2025-03-25
1032 Prostate cancer associated fibroblasts have distinct morphomechanical features that are associated with patient outcome
Garside, A.; Berg-Jacobi, A.; Keerthikumar, S.; Mahajan, V.; Richards, M.; Niranjan, B.; Teng, L.; Choo, N.; Risbridger, G. P.; Lawrence, M. G.; Taubenberger, A. V.
10.1101/2025.03.21.644569 — cancer biology — Posted on 2025-03-25
1039 Optoretinography reveals rapid rod photoreceptor movement upon photoisomerization
Li, H.; Weiss, C. E.; Pandiyan, V. P.; Nanni, D.; Liu, T.; Kung, P. W.; Tan, B.; Barathi, V. A.; Schmetterer, L.; Sabesan, R.; Ling, T.
10.1101/2025.03.22.644466 — bioengineering — Posted on 2025-03-25
1040 Population and adaptation history of 739 Thlaspi arvense natural accessions
Wu, X.; Epstein, R.; Esfahanian, M.; Gautam, B.; Griffiths, M.; Perez, J.; Barry, K.; Lipzen, A.; Daum, C.; Yoshinaga, Y.; Abeyratne, C. R.; Akhmetov, Z.; Arana, S. T.; Bayliss, R.; Borphukan, B.; Brusa, A.; Chhetri, H.; Combs-Giroir, R.; Czech, L.; Dyderski, M. K.; Gjesvold, E. S.; Grzejszczak, G.; Hateley, S.; Heller, N.; Hoffmann, D.; Jaikumar, N.; Jarvis, B. A.; Jawahir, V.; Klisz, M.; Kruse, P.; Lane, M.; Lima, A.; Liu, A.; Madrid, G.; Marlino, M.; McGinn, M.; Pavicic, M.; Perry, W.; Shah, M.; Thomas, J.; Townsend, A.; Wanigarathna, T. L.; Wesley, T.; Connolly, B.; Lim, Y. P.; Puchałka, R
10.1101/2025.03.21.644658 — genomics — Posted on 2025-03-25
1041 Shining a light on daytime coral spawning synchrony across oceans
Moritz, C.; Andrefouet, S.; Azam, C.-S.; Berthe, C.; Fourriere, M.; Goyaud, A.; Grouazel, M.; Siu, G.; Taiarui, M.; Trinh, A.-M.; Liao, V.
10.1101/2025.03.23.643993 — ecology — Posted on 2025-03-25
1043 Diverse microbial exposure exacerbates the development of allergic airway inflammation in adult mice
Elmore, J.; Sahler, J.; Solouki, S.; Koylass, N.; Wang, A.; Nelissen, S.; Redko, A.; Huang, W.; August, A.
10.1101/2025.03.21.644556 — immunology — Posted on 2025-03-25
1045 Lysosome positioning affects NLRP3 inflammasome activation
Matchett, B. J.; Green, J. P.; Seoane, P. I.; Owen, A.; Drobkiewicz, T.; Bennett, H.; Adamson, A.; Lopez-Castejon, G.; Hoyle, C.; Lowe, M.; Brough, D.
10.1101/2025.03.21.644552 — immunology — Posted on 2025-03-25
1049 Disentangling the CHAOS of intrinsic disorder in human proteins
de Vries, I.; Bak, J.; Alvarez Salmoral, D.; Xie, R.; Borza, R.; Konijnenberg, M.; Perrakis, A.
10.1101/2024.10.26.620428 — bioinformatics — Posted on 2025-03-25
1052 Genetic underpinnings of chills from art and music
Bignardi, G.; Admiraal, D.; Eising, E.; Fisher, S. E.
10.1101/2025.03.24.644874 — genetics — Posted on 2025-03-25
1053 Ecological indicators predict functional diversity dynamics following glacier retreat
Losapio, G.; Mottet, L.; Khelidj, N.; Tu, B. N.; Cerabolini, B. E.; Grand, S.; de Vere, N.; Guisan, A.
10.1101/2025.03.20.644423 — ecology — Posted on 2025-03-25
1055 ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death
Yang, Z.-H.; Cai, Z.-y.; Wu, P.; Zhang, B.-X.; Yang, C.-R. Y.; Huang, J.; Wu, L.; Guo, S.-H. G.; Zhou, Y.; Mao, Y.; Yin, Y.; Zhou, R.; Shen, H.-m.; Mo, W.
10.1101/2025.03.24.645142 — cell biology — Posted on 2025-03-25
1057 Structural and regulatory determinants of flagellar motility in Rhodobacterales - The archetypal flagellum of Phaeobacter inhibens DSM 17395
Tomasch, J.; Bartling, P.; Vollmers, J.; Wöhlbrand, L.; Jarek, M.; Rhode, M.; Brinkmann, H.; Freese, H. M.; Rabus, R.; Petersen, J.
10.1101/2025.03.24.645028 — microbiology — Posted on 2025-03-25
1058 The ecological success of freshwater microorganisms is mediated by streamlining and biotic interactions
Rodriguez-Gijon, A.; Pacheco-Valenciana, A.; Milke, F.; Dharamshi, J. E.; Hampel, J. J.; Damashek, J.; Wienhausen, G.; Rodriguez-R, L. M.; Garcia, S. L.
10.1101/2025.03.24.644981 — microbiology — Posted on 2025-03-25
1061 Unraveling dendritic-cell diversity in blood of pigs: welcome tDC and DC3
Baillou, A.; Auray, G.; Brito, F.; Botos, M.; Huber, A.; Summerfield, A.; Talker, S. C.
10.1101/2025.03.21.644143 — immunology — Posted on 2025-03-25
1062 Combining a rhesus cytomegalovirus/SIV vaccine with neutralizing antibody to protect against SIV challenge in rhesus macaques
Coppola, J.; Parren, M.; Bastidas, R.; Saye-Francisco, K.; Malvin, J.; Jardine, J. G.; Gilbride, R. M.; Ojha, S.; Feltham, S.; Morrow, D.; Barber-Axthelm, A.; Bochart, R.; Fast, R.; Oswald, K.; Shoemaker, R.; Lifson, J. D.; Picker, L. J.; Burton, D. R.; Hansen, S. G.
10.1101/2025.03.20.644395 — immunology — Posted on 2025-03-25
1063 Coral skeletal cores as windows into past Symbiodiniaceae community dynamics
Grillo, J. F.; Tirpitz, V.; Reichert, J.; Canesi, M.; Reynaud, S.; Douville, E.; Ziegler, M.
10.1101/2025.03.21.644536 — systems biology — Posted on 2025-03-25
1064 Unlocking seagrass germination: divergent roles of strigolactones and karrikins in Zostera marina
Pieraccini, R.; Picatto, L.; Koedam, N.; Vanreusel, A.; Dolch, T.; Van der Stocken, T.
10.1101/2025.03.21.644661 — plant biology — Posted on 2025-03-25
1065 Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption
Lees, J. J.; Bicici, B.; Berglund, S.; Smith, K.; Galli, G.; Altimiras, J.; Guerrero Bosagna, C.
10.1101/2025.03.21.644511 — physiology — Posted on 2025-03-25
1066 High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds
Yang, D.; Wang, X.; Liu, J.; Nair, P.; Sun, J.; Gong, Y.; Qian, X.; Cui, C.; Zeng, H.; Dong, A.; Harding, R. J.; Burgess-Brown, N.; Beyett, T. S.; Song, D.; Krause, H.; Diamond, M. L.; Bolhuis, D. L.; Brown, N. G.; Arrowsmith, C. H.; Edwards, A. M.; Halabelian, L.; Peng, H.
10.1101/2025.03.20.644436 — pharmacology and toxicology — Posted on 2025-03-25
1067 Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility-Mass Spectrometry
Boatman, A. K.; Kudzin, G. P.; Rock, K. D.; Guillette, M. P.; Robb, F.; Belcher, S. M.; Baker, E.
10.1101/2025.03.20.644452 — pharmacology and toxicology — Posted on 2025-03-25
1071 Imputation strategy for population DNA methylation sequencing data
Duplan, A.; Brandt, S.; Garnier, A.; Tost, J.; Sanchez, L.; Duvaux, L.; Maury, S.; Durufle, H.
10.1101/2025.03.21.644107 — bioinformatics — Posted on 2025-03-25
1076 TOWARDS CLIMATE-SMART REWILDING: AN INTEGRATED FRAMEWORK FOR BIODIVERSITY, CLIMATE CHANGE, AND SOCIETY
Stark, G.; Weissgerber, M.; Fernandez, N.; Quintero-Uribe, L.; Giergiczny, M.; Poulsen, N. R.; Villar, N.; Mols, B.; Bakker, E.; Smith, A. M.; Winkel, G.; Alagador, D.; Rey-Benayas, J.; Espelta, J. M.; Selwyn, M.; Brotons, L.; Kluvankova, T.; Brnkalakova, S.; Kloibhofer, J.; Prestele, R.; Smith, H.; Lazaro-Gonzalez, A.; Buitenwerf, R.; Pearce, E.; Svenning, J.-C.; Santana, J.; Beja, P.; Moreira, F.; Wunder, S.; Svoboda, M.; Vancura, V.; Arneth, A.; Hampe, A.; Pereira, H.
10.1101/2025.03.21.644513 — ecology — Posted on 2025-03-25
1077 Mosquito Dispersal in Context
Sanchez Castellanos, H. M.; Wu, S. L.; Henry, J. M.; Guerra, C. A.; Galick, D. S.; Garcia, G.; Marshall, J. M.; Smith, D. L.
10.1101/2025.03.22.642900 — ecology — Posted on 2025-03-25
1078 Exploring the bioherbicide and biofungicide effects of pistachio hulls for their use in sustainable agriculture
Gonzalez-Hernandez, A. I.; Vivar-Quintana, A.; Saludes-Zanfano, M. I.; Gabri, V. M.; Morales-Corts, M. R.
10.1101/2025.03.21.644490 — ecology — Posted on 2025-03-25
1080 FlickerPrint: An Analysis Package for Measuring Interfacial Tension and Bending Rigidity of Biomolecular Condensates and Vesicles at Scale
Williamson, T. A.; Law, J. O.; Stevenson, T.; Wolf, F.; Jones, C. M.; Tonnessen, E.; Grellscheid, S. N.; Kusumaatmaja, H.
10.1101/2025.03.24.645013 — cell biology — Posted on 2025-03-25
1081 Respiratory Airway Secretory Cells act as Immune Sentinels in Human Distal Airways
Sun, J.; Sun, H.; Jiang, S.; Xie, X.; Wang, D.; Yao, H.; Guan, W.; Zhao, J.; Zhang, W. K.; Xu, T.; Liu, H.
10.1101/2025.03.24.644887 — cell biology — Posted on 2025-03-25
1082 Armed with PRICKLE(3)s: Stabilizing WNT/PCP complexes against RNF43-mediated ubiquitination
Radaszkiewicz, K.; Radaszkiewicz, T.; Kolarova, P.; Paclikova, P.; Gomoryova, K.; Barta, T.; Hanakova, K.; Zdrahal, Z.; Harnos, J.
10.1101/2025.03.24.644882 — cell biology — Posted on 2025-03-25
1084 Ser14-phosphorylated Rpn6 Limits Proteostasis Impairment and Pathology in Both Brain and Heart of Tauopathy Mice
Ejaz, S.; Sternburg, J. O.; Rezvani, K.; Ahammed, M. S.; Giri, S.; Liu, J.; Wang, H.; Wang, X.
10.1101/2025.03.24.645024 — cell biology — Posted on 2025-03-25
1086 Different mechanisms link gain and loss of kinesin functions to axonal degeneration
Liew, Y.-T.; Bailey, D. M. D.; Cairns, W.; Day, M.; Dajas-Bailador, F.; Jones, E.; McCann, S.; Landgraf, M.; Lorenzo-Cisneros, L.; Murphy, T.; Owens, M.; Pant, D.; Parkin, J.; Tortoishell, H.; Voelzmann, A.; Prokop, A.
10.1101/2024.12.31.630930 — neuroscience — Posted on 2025-03-25
1088 Soybean RIN4 represents a mechanistic link between plant immune and symbiotic signaling
Toth, K.; Kim, D.; Cho, S.-H.; Nguyen, C. T.; Hartanto, C.; Michno, J.-M.; Stec, A. O.; Stupar, R. M.; Stacey, G.
10.1101/2023.09.12.557450 — plant biology — Posted on 2025-03-25
1089 Hyperspectral Sensing for High-Throughput Screening of Boron Tolerance in Grapevines
Lupo, Y.; Sharma, S.; Munoz, J.; Nunez, V.; Gaspar, P.; McElrone, A. J.; Diaz-Garcia, L.
10.1101/2025.03.21.644478 — plant biology — Posted on 2025-03-25
1090 NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer
Zhao, S.; Lin, J.; Zhu, B.; Jin, Y.; Dong, Q.; Ruan, X.; Jin, D.; Yi, Y.; Bai, B.; Li, H.; Liang, D.; Lu, J.; Meng, L.; Wang, X.; Cui, Y.; Gu, Y.; Shen, X.; Lu, X.; Rao, S.; Sun, W.
10.1101/2024.11.05.622078 — cancer biology — Posted on 2025-03-25
1095 CONSERVED NUCLEAR MORPHOLOGY IDENTIFIES FUNCTIONAL RADIAL GLIA NEURAL PROGENITORS
Soriano-Esque, J. P.; Borau, C.; Sortino, R.; Garma, L. D.; Ortega, J. A.; Asin, J.; Alcantara, S.
10.1101/2025.01.09.632137 — developmental biology — Posted on 2025-03-25
1096 CRISPR-Cas9 Screening Reveals Microproteins Regulating Adipocyte Proliferation and Lipid Metabolism
Pai, V. J.; Shan, H.; Donaldson, C.; Vaughan, J.; O'Connor, C.; Liem, M.; Pinto, A.; Diedrich, J. K.; Saghatelian, A.
10.1101/2025.03.21.644636 — cell biology — Posted on 2025-03-25
1097 In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment
Rose, K.; Herrmann, E.; Kakudji, E. V.; Lizarrondo, J.; Celebi, A. Y.; Wilfling, F.; Lewis, S. C.; Hurley, J. H.
10.1101/2025.03.24.645001 — cell biology — Posted on 2025-03-25
1099 ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis
Fuller, D. M.; Wu, Y.; Schueder, F.; Rasool, B.; Nag, S.; Korfhage, J. L.; Garcia-Milian, R.; Melnyk, K. D.; Bewersdorf, J.; De Camilli, P.; Melia, T.
10.1101/2025.03.24.645038 — cell biology — Posted on 2025-03-25
1100 Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Ali, M. M.; Nookaew, I.; Resende-Coelho, A.; Marques-Carvalho, A.; Aaron Warren, A.; Fu, Q.; Kim, H.-N.; OBrien, C. A.; Almeida, M.
10.1101/2025.03.24.643319 — cell biology — Posted on 2025-03-25
1101 The differential mechanisms of eIF4A1-mediated translational activation instructed by distinct RNA features
Schmidt, T.; Turnbull, A. P.; Gupta, A.; Waldron, J. A.; Pollock, K.; Munro, J.; Nepravishta, R.; Herviou, P.; Dabrowska, A.; Hodge, K.; Voelker, A. M.; Pang, L.; Pasquali, C.; Kanellos, G.; Zanivan, S.; Sansom, O. J.; Beaudoin, J.-D.; Bushell, M.
10.1101/2025.03.24.644895 — cell biology — Posted on 2025-03-25
1102 T-World: A highly general computational model of a human ventricular myocyte
Tomek, J.; Zhou, X.; Martinez-Navarro, H.; Holmes, M.; Bury, T.; Arantes Berg, L.; Tomkova, M.; Jo, E.; Nagy, N.; Bertrand, A.; Bueno-Orovio, A.; Colman, M. A.; Rodriguez, B.; Bers, D. M.; Heijman, J.
10.1101/2025.03.24.645031 — cell biology — Posted on 2025-03-25
1103 An Assessment of the Functional State of Endothelial Colony Forming Cells from Patients with Diabetes Mellitus and Chronic Limb Threatening Ischemia
Lyons, C. J.; Creane, M.; Soomro, N.; Sanz-Nogues, C.; Shafik, L.; Straszewicz, A.; Griffin, T. P.; Stitt, A.; O'Brien, T.
10.1101/2025.03.24.644359 — cell biology — Posted on 2025-03-25
1104 The ganglioside GD3 and its Synthase (ST8SIA1) as novel senescence markers associated with osteoarthritis
Fissoun, C.; Maroun, G.; Silva, R.; Milano, M.; Guibert, B.; Dagneaux, L.; Ferreira-Lopez, R.; Commes, T.; Gilson, E.; Jorgensen, C.; Cherfils-Vicini, J.; Pers, Y.-M.; Brondello, J.-M.
10.1101/2025.03.22.640206 — cell biology — Posted on 2025-03-25
1110 Parkinson's Paradox: Alpha-synuclein's Selective Strike on SNc Dopamine Neurons over VTA
Phan, L.; Miller, D.; Gopinath, A.; Gunther, D.; Kiel, K.; Quintin, S.; Borg, D.; Hasanpour-Segherlou, Z.; Newman, A.; Sorrentino, Z.; Miller, E.; Seibold, J.; Hoh, B.; Giasson, B.; Khoshbouei, H.
10.1101/2025.03.24.644952 — neuroscience — Posted on 2025-03-25
1111 Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
Wells, R. C.; Akkapeddi, P.; Chan, D.; Joy, D.; Chau, R.; Chow, J.; Moshkforoush, A.; Cherf, G. M.; Chien, E. Y. T.; Clemens, A.; Pizzo, M. E.; Qerqez, A. N.; Tran, T.; Becerra, I.; Dugas, J. C.; Duque, J.; Earr, T. K.; Huynh, D.; Kim, D. J.; Leung, A. W.-S.; Liang, E.; Nguyen, H. N.; Robles-Colmenares, Y.; Kane, H.; Roche, E.; Sacayon, P.; Xa, K.; Solanoy, H.; Dennis, M. S.; Lewcock, J. W.; Watts, R. J.; Kariolis, M. S.; Thorne, R. G.; Koth, C. M.; Calvert, M. E. K.; Zuchero, Y. J. Y.; Chew, K. S.
10.1101/2025.03.24.645085 — neuroscience — Posted on 2025-03-25
1117 Evolution of sensory systems underlies the emergence of predatory feeding behaviours in nematodes
Roca, M.; Eren, G. G.; Boeger, L.; Didenko, O.; Lo, W.-s.; Scholz, M.; Lightfoot, J. W.
10.1101/2025.03.24.644997 — neuroscience — Posted on 2025-03-25
1124 Aligned representation of visual and tactile motion directions in hMT+/V5 and fronto- parietal regions
Shahzad, I.; Battal, C.; Cerpelloni, F.; Van Audenhaege, A.; Mouraux, A.; Collignon, O.
10.1101/2025.03.24.645080 — neuroscience — Posted on 2025-03-25
1125 Impacts of competition and phenotypic plasticity on the viability of adaptive therapy
Vibishan, B.; Jain, P.; Sharma, V.; Hari, K.; Kadelka, C.; George, J. T.; Jolly, M. K.
10.1101/2025.03.20.644475 — systems biology — Posted on 2025-03-25
1127 Integrative Gene and Isoform Co-expression Networks Reveal Regulatory Rewiring in Stress-related Psychiatric Disorders
Rehawi, G.; Hagenberg, J.; Brueckl, T. M.; Kopf-Beck, J.; Saemann, P.; Moyon, L.; Binder, E. B.; List, M.; Marsico, A.; Knauer-Arloth, J.
10.1101/2025.03.24.640781 — systems biology — Posted on 2025-03-25
1129 Altered placental morphology and metabolomic profile in as-sociation with uncomplicated metabolically healthy obese pregnancy
Sarr, O.; Rajagopaul, A.; Zhao, S.; Wang, X.; Grynspan, D.; Eastabrook, G.; Li, L.; Regnault, T.; de Vrijer, B.
10.1101/2025.03.20.644371 — physiology — Posted on 2025-03-25
1131 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA
Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.
10.1101/2024.11.25.625221 — paleontology — Posted on 2025-03-25
1132 ProSynTaxDB: A curated protein database and workflow for taxonomic classification of Prochlorococcus and Synechococcus in metagenomes
Coe, A.; Mullet, J. I.; Vo, N. N.; Berube, P. M.; Anjur-Dietrich, M.; Salcedo, E.; Parker, S. M.; VonEmster, K.; Bliem, C.; Arellano, A. A.; Castro, K. G.; Becker, J. W.; Chisholm, S. W.
10.1101/2025.03.20.644373 — bioinformatics — Posted on 2025-03-25
1135 DiNovo: high-coverage, high-confidence de novo peptide sequencing using mirror proteases and deep learning
Cao, Z.; Peng, X.; Zhang, D.; Zhou, P.; Kang, L.; Chi, H.; Wu, R.; Cheng, Z.; Zhang, Y.; Dai, J.; Li, Y.; Yao, L.; Li, X.; Yang, J.; Wang, H.; Xu, P.; Fu, Y.
10.1101/2025.03.20.643920 — bioinformatics — Posted on 2025-03-25
1144 Assessment of the adverse effects of pollution on farmland bird diversity in contemporary agricultural landscapes
Sur, M.; Kleijn, D.; Soons, M.; Foppen, R.; Hallmann, C. A.; Jongejans, E. A.; Posthuma, L.; Sierdsema, H. A.; Slootweg, J.; Turnhout, C. v.; Kroon, H. d.
10.1101/2025.03.23.644816 — ecology — Posted on 2025-03-25
1146 MLL1 complex is a critical regulator of fetal hemoglobin repression
Han, Y.; Gudmundsdottir, B.; Gudmundsson, K. O.; Roy, K. R.; Tisdale, J.; Du, Y.
10.1101/2025.03.24.645036 — developmental biology — Posted on 2025-03-25
1147 Polyploidy promotes transformation of epithelial cells into non-professional phagocytes
Huang, Y.-C.; Caique, A. M. C.; Ruiz, N. V.; Wang, X.-F.; Jevitt, A.; Breneman, C. M.; Han, C.; Deng, W.-M.
10.1101/2025.03.24.645044 — developmental biology — Posted on 2025-03-25
1149 Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-DrivenMonopoiesis
Loureiro, Z. Y.; Samant, A.; Desai, A.; DeSouza, T.; Cirka, H.; Ceesay, M.; Kostyra, D.; Joyce, S.; Khair, L.; Solivan-Rivera, J.; Ziegler, R.; Ketelut Carneiro, N.; Tsai, L. A.; Brehm, M.; Messina, L. M.; Fitzgerald, K. A.; Rosen, E.; Corvera, S.; Nguyen, T. T.
10.1101/2023.08.29.555167 — developmental biology — Posted on 2025-03-25
1151 Circulating extracellular vesicles can transport stress signals to the male germline
Alshanbayeva, A.; Steg, L.; Othman, A.; Manuella, F.; Arzate-Mejia, R. G.; Zamboni, N.; Mansuy, I. M.
10.1101/2025.03.21.644551 — cell biology — Posted on 2025-03-25
1152 The Hitchdock domain in Kinesin-2 Tail Enables Adaptor Assembly and Cargo Binding
Jiang, X.; Danev, R.; Niu, B.; Ohtsuki, S.; Yanagisawa, H.; Hirokawa, N.; Kikkawa, M.
10.1101/2025.03.21.644525 — cell biology — Posted on 2025-03-25
1154 TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase
Bugda Gwilt, K.; Wijayratne, D.; Emberling, G.; Gillette, L.; La, J.; Zheng, H. B.; Wendel, D.; Karam, L. B.; Muise, A. M.; Snapper, S. B.; Lencer, W. I.; Raghunathan, K.; Thiagarajah, J. R.
10.1101/2025.03.22.644724 — cell biology — Posted on 2025-03-25
1155 Patient-derived liver biopsy organoids enable precision alcohol-associated liver disease modeling
Arino, S.; Zannatto, L.; Martinez-Garcia de la Torre, R. A.; Ferrer-Lorente, R.; Cratacos-Gines, J.; Belen Rubio, A.; Perez, M.; Aguilar-Bravo, B.; Serrano, G.; Atkinson, S.; Xu, Z.; Cantallops-Vila, P.; Sererols-Vinas, L.; Ruiz-Blazquez, P.; Rill, A.; Lozano, J. J.; Coll, M.; Ochoa, I.; Affo, S.; Moles, A.; Mereu, E.; Bataller, R.; Pose, E.; Sancho-Bru, P.
10.1101/2025.03.22.644563 — cell biology — Posted on 2025-03-25
1157 Large-scale discovery, analysis, and design of protein energy landscapes
Ramos Ferrari, A. J.; Dixit, S.; Thibeault, J.; Garcia, M.; Houliston, S.; Ludwig, R. W.; Notin, P.; Phoumyvong, C. M.; Martell, C. M.; Jung, M. D.; Tsuboyama, K.; Carter, L.; Arrowsmith, C. H.; Guttman, M.; Rocklin, G. J.
10.1101/2025.03.20.644235 — biophysics — Posted on 2025-03-25
1158 Pervasive ancestry bias in variant effect predictors
Pathak, A. K.; Bora, N.; Badonyi, M.; Livesey, B. J.; SG10K_Health Consortium, ; Ngeow, J.; Marsh, J. A.
10.1101/2024.05.20.594987 — bioinformatics — Posted on 2025-03-25
1159 Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties
Morrison, A. I.; Jäger, J.; de Winde, C. M.; Roest, H. P.; J.W. van der Laan, L.; Gibbs, S.; Koning, J. J.; Mebius, R. E.
10.1101/2025.03.20.644364 — bioengineering — Posted on 2025-03-25
1162 IL-21 selectively augments cytotoxic potential of antigen-activated MAIT cells
Wedlock, L. E.; Lamichhane, R.; Gilmer, S. C. L.; Vernall, A. J.; Ussher, J. E.
10.1101/2025.03.20.644465 — immunology — Posted on 2025-03-25
1166 Substrate viscoelasticity regulates fibroblast adhesion and migration
Paddillaya, N.; Rao, A.; Shrivastava, A.; Jamir, I.; Sengupta, K.; Gundiah, N.
10.1101/2025.03.20.644304 — bioengineering — Posted on 2025-03-25
1168 Sox9-dependent plasticity of esophageal progenitors is fine-tuned by cues from the microenvironment
Descampe, L.; Dassy, B.; Charara, F.; Craciun, L.; Verset, L.; Pirard, S.; Verheye, Q.; Leprovost, M.; Garcia, M.-I.; Vercauteren Drubbel, A.; Beck, B.
10.1101/2025.03.21.644516 — cell biology — Posted on 2025-03-25
1169 CompBioAgent: an LLM-powered agent for single-cell RNA-seq data exploration
Zhang, H.; Sun, Y. H.; Hu, W.; Cui, X.; Ouyang, Z.; Cheng, D.; Zhang, X.; Zhang, B.
10.1101/2025.03.17.643771 — bioinformatics — Posted on 2025-03-25
1170 Vocal ontogeny in Mus musculus
Pranic, N. M.; Singh, R.; Rabinovich, J.; Ferry, D.; Tschida, K. A.
10.1101/2025.03.24.644972 — animal behavior and cognition — Posted on 2025-03-25
1171 Neotenic transcriptomic features in the adult turquoise killifish brain
Burgos-Ruiz, A. M.; Naranjo, S.; Hernandez-Perez, M. d. V.; Ardila-Garcia, L.; Moreno-Onate, M.; Fernandez-Minan, A.; de los Reyes-Benitez, A.; Lopez-Rios, J.; Nusspaumer, G.; Tena, J. J.
10.1101/2025.03.24.645095 — genomics — Posted on 2025-03-25
1172 Long-term hunter-gatherer continuity in the Rhine-Meuse region was disrupted by local formation of expansive Bell Beaker groups
Olalde, I.; Altena, E.; Bourgeois, Q.; Fokkens, H.; Amkreutz, L.; Deguilloux, M.-F.; Fichera, A.; Flas, D.; Gandini, F.; Kegler, J. F.; Kootker, L. M.; Leijnse, K.; Kooijmans, L. L.; Lauwerier, R.; Miller, R.; Molthof, H.; Noiret, P.; Raemaekers, D. C. M.; Rivollat, M.; Smits, L.; Stewart, J. R.; ten Anscher, T.; Toussaint, M.; Callan, K.; Cheronet, O.; Frost, T.; Iliev, L.; Mah, M.; Micco, A.; Oppenheimer, J.; Patterson, I.; Qiu, L.; Soos, G.; Workman, J. N.; Edwards, C. J.; Lazaridis, I.; Mallick, S.; Patterson, N.; Rohland, N.; Richards, M. B.; Pinhasi, R.; Haak, W.; Pala, M.; Reich, D.
10.1101/2025.03.24.644985 — genomics — Posted on 2025-03-25
1177 Antennal RNAseq reveals odorant receptors with sex-biased expression in the common eastern firefly, Photinus pyralis
Lower, S. E.; Pring, S.; Tran, H.; Martinson, K.; Deering, S.; Price, M. A.; Vestal, B.; Pask, G. M.; Collins, D. B.; Mitchell, R. F.
10.1101/2025.03.21.644631 — evolutionary biology — Posted on 2025-03-25
1182 Coincident bursts of high frequency oscillations across the human cortex coordinate large-scale memory processing.
Prathapagiri, S.; Cimbalnik, J.; Salinas, J. G.; Galanina, M.; Jurkovicova, L.; Daniel, P.; Kojan, M.; Roman, R.; Pail, M.; Fortuna, W.; Sluzewska-Niedzwiedz, M.; Tabakow, P.; Czyzewski, A.; Brazdil, M.; Kucewicz, M.
10.1101/2025.03.24.644989 — neuroscience — Posted on 2025-03-25
1185 Prognostic and biological roles of Parkinson's disease genes in cancer
fiume, s.; molinari, f.; vai, b.; Poletti, S.; citterio, g.; Fiumara, F.; papin, s.; paganetti, p.; Callari, M.; colnaghi, l.
10.1101/2025.03.22.644759 — bioinformatics — Posted on 2025-03-24
1187 Genetic association between posterior parietal cortex and intelligence
yang, d.; yang, x.; peng, j.; Lu, J.; Hao, X.; Guo, S.; li, j.; Chen, R.; Xu, C.; Xiang, L.; Xu, T.
10.1101/2025.03.21.644693 — genetics — Posted on 2025-03-24
1188 Chikungunya virus susceptibility increases in the absence of mk2b and mk3 genes in zebrafish model
Keshry, S. S.; Nayak, U.; Mamidi, P.; Mohanty, S.; Ghorai, U.; Swain, R. K.; Chattopadhyay, S.
10.1101/2025.03.24.644917 — molecular biology — Posted on 2025-03-24
1189 Prevalence of Oxalotrophy in the Human Microbiome
Junier, T.; Palmieri, F.; Ubags, N. D.; Trompette, A.; Koutsokera, A.; Junier, P.; Pagni, M.; Neuenschwander, S.
10.1101/2025.03.24.644979 — microbiology — Posted on 2025-03-24
1190 An in vivo fitness gene of Toxoplasma, MIC11, is essential for PLP1-mediated egress from host cells
Tachibana, Y.; Sasai, M.; Kosako, H.; Takashima, E.; Carruthers, V. B.; Soldati-Favre, D.; Yamamoto, M.
10.1101/2025.03.24.644834 — microbiology — Posted on 2025-03-24
1194 Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30
Izumikawa, K.; Shida, T.; Onodera, Y.; Tashima, Y.; Miyao, S.; Suda, T.; Suda, Y.; Sugihara, M.; Noguchi, T.; Nagahama, M.
10.1101/2025.03.04.641417 — molecular biology — Posted on 2025-03-24
1195 Discovering Polyphosphate and Polyhydroxyalkanoate-Accumulating Organisms Across Ecosystems: Phenotype-targeted Genotyping via FACS-sequencing
Yan, Y.; Lee, J.; Baldwin, M.; Li, G.; Han, I.; Wang, Z.; He, P.; Shrinivasan, V.; Wicked-Do, L.; Gore, M.; Gu, A. Z.
10.1101/2025.03.24.644850 — microbiology — Posted on 2025-03-24
1196 Human herpesvirus 1 associated with epizootics in Belo Horizonte, Minas Gerais, Brazil
Oliveira, G. F. G.; Biccas, M. F.; Jacob, D.; de Oliveira Paschoal, A. M.; de Oliveira, M. A.; Alves, P. A.; Barreto, C.; da Rocha Vilela, D. A.; Teixeira, E. P. T.; Stehling, T. L.; Mendes, T. M.; Silva, M. C.; Almeida, M. G.; Sonoda, I. V.; de Mello, E. M.; da Gama, F. E. N.; Hanley, K. A.; Vasilakis, N.; Drumond, B. P.
10.1101/2025.03.24.645062 — microbiology — Posted on 2025-03-24
1197 Prokaryotic mechanosensitive channels mediate copper influx
Ghnamah, Y.; Palmer, C. D.; Livnat-Levanon, N.; Grupper, M.; Rosenzweig, A. C.; Lewinson, O.
10.1101/2025.03.24.644891 — microbiology — Posted on 2025-03-24
1199 Structural determinants of rotavirus proteolytic activation
Asensio-Cob, D.; Mata, C. P.; Gomez-Blanco, J.; Vargas, J.; Rodriguez, J. M.; Luque, D.
10.1101/2025.03.24.644915 — microbiology — Posted on 2025-03-24
1201 Experimental transmission of African swine fever virus by Ornithodoros lahorensis (Acari: Argasidae)
Luo, J.; Jia, H.; Zhao, S.; Ren, Q.; Obaid, M. K.; Yang, J.; Guan, G.; Yin, H.; Liu, G.; Niu, Q.
10.1101/2025.03.24.644965 — microbiology — Posted on 2025-03-24
1202 Flexibility and modulation of translation initiation in enterovirus genomes
O'Connor, R. L.; Cook, G. M.; Hankinson, J.; Fominykh, K.; Cheng, S. H.; Nash, D. A.; Cenier, A.; Nayak, K. M.; Graham, S. C.; Deane, J. E.; Zilbauer, M.; Firth, A. E.; Lulla, V.
10.1101/2025.03.24.645098 — microbiology — Posted on 2025-03-24
1203 Widespread heteroresistance to antibiotics in Lactobacillus species
Rivera-Rodriguez, D. E.; Busby, C.; Cervantes-Barragan, L.; Weiss, D. S.
10.1101/2025.03.24.644958 — microbiology — Posted on 2025-03-24
1204 A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system
Nguyen, E.; Agbavor, C.; Steenhaut, A.; Pratyush, M.; Hiller, N. L. A.; Cahoon, L. A.; Mikheyeva, I.; Ng, W.-L.; Bridges, A. A.
10.1101/2025.03.24.645060 — microbiology — Posted on 2025-03-24
1206 Harnessing Diversity Generating Retroelements for in vivo targeted hyper-mutagenesis
Laurenceau, R.; Rochette, P.; Lopez-Rodriguez, E.; Fan, C.; Maire, A.; Vittot, P.; Cerdas-Mejias, K. M.; Bouvier, A.; Chrysostomou, T.; Bikard, D.
10.1101/2025.03.24.644984 — synthetic biology — Posted on 2025-03-24
1208 Deep learning-based 3D spatial transcriptomics with X-Pression
Turos, D.; Gladiseva, L.; Botos, M.; He, C.; Barut, G. T.; Veiga, I. B.; Ebert, N.; Bonnin, A.; Chanfon, A.; Grau-Roma, L.; Valdeolivas, A.; Rottenberg, S.; Thiel, V.; Moreira, E. A.
10.1101/2025.03.21.644627 — bioinformatics — Posted on 2025-03-24
1209 Evolved microbial diversity enables combinatoric biosensing in complex environments
Hasty, J.; Chiang, A. J.; Csicsery, N.; O'Laughlin, R.; Baumgart, L.; Stasiowski, E.; Nguyen, P.; Doughty, A.; Ashraf, M.; Mink, R.; Olson, E. C.; Ferry, M.; Feist, A. M.; Hao, N.; Zengler, K.
10.1101/2025.03.24.645055 — bioengineering — Posted on 2025-03-24
1210 Enthalpy-entropy trade-offs in the evolution of ligand specificity in a superfamily of transcription factors
Georgelin, R.; Bott, H.; Kaczmarski, J.; Frkic, R.; Tan, L. L.; Tokuriki, N.; Spence, M. A.; Jackson, C.
10.1101/2025.03.23.644840 — biochemistry — Posted on 2025-03-24
1211 Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast Candida albicans
Henry, M.; Khouas, M.; Theberge-Julien, G.; Vincent, A. T.; Villeneuve, L.; Rheaume, E.; Tardif, J.-C.; Sellam, A.
10.1101/2025.03.24.644998 — microbiology — Posted on 2025-03-24
1212 A double-staining automated flow cytometry method for real-time monitoring of bacteria in continuous bioreactors
Lopez Galvez, J.; Schoenfelder, E.; Mayer, H.; Schiessl, K.; Silva, M. O. D.; Harms, H.; Mueller, S.
10.1101/2025.03.24.644962 — microbiology — Posted on 2025-03-24
1213 Molecular basis of sarbecovirus evolution and receptor tropism in natural hosts, potential intermediate hosts, and humans
Kosugi, Y.; Matsumoto, K.; Lytras, S.; Plianchaisuk, A.; Tolentino, J. E.; Fujita, S.; Yo, M. S.; Luo, C.; Kim, Y.; Shihoya, W.; Ito, J.; Nureki, O.; Sato, K.
10.1101/2025.03.22.644775 — microbiology — Posted on 2025-03-24
1214 Quantitative Analysis of Coupled Carbon and Energy Metabolism for Lignin Carbon Utilization in Pseudomonas putida
Zhou, N.; Wilkes, R. A.; Chen, X.; Teitel, K. P.; Belgrave, J. A.; Beckham, G. T.; Werner, A. Z.; Yu, Y.; Aristilde, L.
10.1101/2025.03.24.645021 — microbiology — Posted on 2025-03-24
1215 Studies on Gene Enhancer with KSHV mini-chromatin
Inagaki, T.; Kumar, A.; Wang, K.-H.; Komaki, S.; Espera, J. M.; Bautista, C. S. A.; Nakajima, K.-i.; Izumiya, C.; Izumiya, Y.
10.1101/2025.03.24.644916 — microbiology — Posted on 2025-03-24
1216 Mutualistic interactions between Escherichia coli and Bifidobacterium bifidum enable degradation of human milk oligosaccharides in healthy infants
Seki, D.; Pollak, S.; Kujawska, M.; Kiu, R.; Acuna-Gonzales, A.; Crouch, L.; Bakshani, C.; Chivers, P.; Mommers, M.; van Best, N.; Penders, J.; Hall, L. J.
10.1101/2025.03.24.645027 — microbiology — Posted on 2025-03-24
1218 Quantifying viral pandemic potential from experimental transmission studies
Somsen, E. D.; Septer, K. M.; Field, C. J.; Patel, D. R.; Lowen, A. C.; Sutton, T. C.; Koelle, K.
10.1101/2025.03.24.645081 — microbiology — Posted on 2025-03-24
1219 Adaptive pangenomic remodeling in the Azolla cyanobiont amid a transient microbiome
Armitage, D. W.; Alonso-Sanchez, A. G.; Coy, S. R.; Cheng, Z.; Hagenbeek, A.; Lopez-Martinez, K. P.; Phua, Y. H.; Sears, A. R.
10.1101/2025.03.24.644982 — microbiology — Posted on 2025-03-24
1220 BitBIRCH Clustering Refinement Strategies
Lopez Perez, K.; Huddleston, K.; Jung, V.; Miranda Quintana, R. A.
10.1101/2025.03.20.644337 — bioinformatics — Posted on 2025-03-24
1222 Rewired m6A methylation of promoter antisense RNAs in Alzheimer disease regulates global gene transcription in the 3D nucleome
Hu, B.; Shi, Y.; Xiong, F.; Chen, Y.-T.; Zhu, X.; Carrillo, E.; Wen, X.; Drolet, N. A.; Rajpurohit, C.; Xu, X.; Lee, D.-F.; Soto, C.; Zhong, S.; Jayaraman, V.; Zheng, H.; LI, W.
10.1101/2025.03.22.644756 — molecular biology — Posted on 2025-03-24
1223 Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns
Schneeberger, P. H. H.; Dommann, J.; Rahman, N. O.; Huerlimann, E.; Sayasone, S.; Ali, S. M.; Coulibaly, J. T.; keiser, J.
10.1101/2025.03.21.641387 — microbiology — Posted on 2025-03-24
1224 Functional specialisation of multisensory temporal integration in the mouse superior colliculus
Bianchini, G.; Razafindrahaba, I.; Moglie, M. J.; Konstantinou, G.; Cano-Ferrer, X.; Imbert, A.; Iacaruso, F.
10.1101/2025.02.11.637674 — neuroscience — Posted on 2025-03-24
1225 Multimodal precision MRI of the individual human brain at ultra-high fields
Cabalo, D. G.; Leppert, I. R.; Thevakumaran, R.; Dekraker, J.; Hwang, Y.; Royer, J.; Kebets, V.; Tavakol, S.; Wang, Y.; Zhou, Y.; Benkarim, M. O.; Eichert, N.; Paquola, C.; Tardif, C. L.; Rudko, D.; Smallwood, J.; Cruces, R. R.; Bernhardt, B.
10.1101/2024.06.17.596303 — neuroscience — Posted on 2025-03-24
1226 Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa
Song, H. B.; Campello, L.; Mondal, A.; Chen, H. Y.; English, M. A.; Glen, M.; Vanlandingham, P.; Farjo, R.; Swaroop, A.
10.1101/2024.11.06.622146 — neuroscience — Posted on 2025-03-24
1232 Increased levels of folic acid reduce survival 24 hours after hypoxia in male and female Drosophila melanogaster
Gunnala, S.; Harrison, A.; Juba, A.; Ashcraft, P.; Bottiglieri, T.; Buhlman, L. M.; Jadavji, N. M.
10.1101/2024.10.23.619884 — neuroscience — Posted on 2025-03-24
1233 Neuronal Silencing and Protection in a Mouse Model of Demyelination
Das, A.; Borovicka, J.; Tobin, H.; Bhatia, S.; Icardi, J.; Tahmasebi, G.; Agochiya, P.; Singh, S.; Manworren, J.; Isak, P.; Trapp, B.; Dana, H.
10.1101/2025.02.03.636344 — neuroscience — Posted on 2025-03-24
1234 Species-specific interactions with apex carnivores yield unique benefits and burdens for mesocarnivores
Binder, W.; Rabe, J.; Lowe, Z.; Scott, G.; Lacey, C.; King, E.; Stahler, D. R.; Chakrabarti, S.
10.1101/2024.08.17.608414 — ecology — Posted on 2025-03-24
1235 Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson's Disease
Jaffery, R.; Zhao, Y.; Ahmed, S.; Schumacher, J. G.; Ahn, J.; Shi, L.; Wang, Y.; Tan, Y.; Chen, K.; Tawbi, H.; Wang, J.; Schwarzschild, M. A.; Peng, W.; Chen, X.
10.1101/2025.03.20.644460 — neuroscience — Posted on 2025-03-24
1236 Glutamate indicators with increased sensitivity and tailored deactivation rates
Aggarwal, A.; Negrean, A.; Chen, Y.; Iyer, R.; Reep, D.; Liu, A.; Palutla, A.; Xie, M. E.; MacLennan, B.; Hagihara, K. M.; Kinsey, L. W.; Sun, J. L.; Yao, P.; Zheng, J.; Tsang, A.; Tsegaye, G.; Zhang, Y.; Patel, R. H.; Arthur, B. J.; Hiblot, J.; Leippe, P.; Tarnawski, M.; Marvin, J. S.; Vevea, J. D.; Turaga, S. C.; Tebo, A. G.; Carandini, M.; Rossi, L. F.; Kleinfeld, D.; Konnerth, A.; Svoboda, K.; Turner, G. C.; Hasseman, J.; Podgorski, K.
10.1101/2025.03.20.643984 — neuroscience — Posted on 2025-03-24
1238 Reward Network Activations of Win versus Loss in a Monetary Gambling Task
Kamarajan, C.; Ardekani, B.; Pandey, A.; Pandey, G.; Kinreich, S.; Kuang, W.; Meyers, J. L.; Porjesz, B.
10.1101/2025.03.20.644448 — neuroscience — Posted on 2025-03-24
1241 Feeding-fasting cycle of obesogenic food determines glucocorticoid neuromodulation of cortico-hippocampal activities sustaining long-term memory
Chakraborty, P.; Dromard, Y.; Andre, E. M.; Dedin, M.; Arango-Lievano, M.; Besnard, A.; Santos Silva, T.; Helbling, J. c.; Ferreira, G.; Challet, E.; Moisan, M. P.; jeanneteau, f.
10.1101/2025.03.21.644570 — neuroscience — Posted on 2025-03-24
1242 In vivo reconstruction of Duvernoy's postmortem vasculature images
Gulban, O. F.; Stirnbern, R.; Tse, D. H. Y.; Pizzuti, A.; Koiso, K.; Archila-Melendez, M. E.; Huber, R.; Bollmann, S.; Kay, K.; Ivanov, D.
10.1101/2025.03.23.644588 — neuroscience — Posted on 2025-03-24
1243 Comprehensive profiling of anaesthetised brain dynamics across phylogeny
Luppi, A. I.; Uhrig, L.; Tasserie, J.; Shafiei, G.; Muta, K.; Hata, J.; Okano, H.; Golkowski, D.; Ranft, A.; Ilg, R.; Jordan, D.; Gini, S.; Liu, Z.-Q.; Yee, Y.; Signorelli, C. M.; Cofre, R.; Destexhe, A.; Menon, D.; Stamatakis, E. A.; Connor, C. W.; Gozzi, A.; Fulcher, B. D.; Jarraya, B.; Misic, B.
10.1101/2025.03.22.644729 — neuroscience — Posted on 2025-03-24
1244 American ginseng (Panax quinquefolius L.) extracts (G1899) reverse stress-induced behavioral abnormalities in mice
Lee, R.; Wiles, M. J.; Black, E. R.; Roh, S. H.; Bouckova, E.; Wustrau, M. H.; Flowers, J. C.; Vetter, P. E.; Lee, J.; Han, B.-C.; Kim, S.
10.1101/2025.03.21.644575 — neuroscience — Posted on 2025-03-24
1246 cAMP-related second messenger pathways modulate hearing function in Aedes aegypti mosquitoes
Xu, Y. Y. J.; Loh, Y. M.; Lee, T.-T.; Chen, W.-T.; Loh, W.; Ohashi, T. S.; Eberl, D. F.; Andres, M.; Su, M. P.; Kamikouchi, A.
10.1101/2025.03.23.644695 — neuroscience — Posted on 2025-03-24
1247 Simultaneous zero echo time fMRI of rat brain and spinal cord
Laakso, H.; Wu, L.; Ponticorvo, S.; Salo, R. A.; Paasonen, J.; Paasonen, E.; Kettunen, M.; Lagore, R. L.; DeLabarre, L.; Polcyn, E.; Adriany, G.; Isturiz, J.; Koski, D. M.; Idiyatullin, D.; Gröhn, O.; Mangia, S.; Michaeli, S.
10.1101/2025.03.20.644420 — neuroscience — Posted on 2025-03-24
1249 The cellular and behavioral blueprints of chordate rheotaxis.
Tolstenkov, O.; Ozawa, A.; Allombert-Blaise, C.; Hiraiwa, T.; Chatzigeorgiou, M.
10.1101/2025.03.22.644710 — neuroscience — Posted on 2025-03-24
1250 Intracortical bipolar stimulation allows selective activation of neuronal populations in the cortex
Schelles, M.; Verhaege, A.; Van Rompaey, N.; Goyvaerts, L.; Wierda, K.; Ceyssens, F.; Kraft, M.; Bonin, V.
10.1101/2025.03.21.644593 — neuroscience — Posted on 2025-03-24
1252 A post-mortem investigation of the locus coeruleus- noradrenergic system in resilience to childhood abuse
Slavova, D.; Davoli, M. A.; Keime, C.; Frossi, G.; Vigneault, E.; Nagy, C.; Turecki, G.; Giros, B.; Mechawar, N.; Isingrini, E.
10.1101/2025.03.22.644719 — neuroscience — Posted on 2025-03-24
1253 A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina
Shen, N.; Fitzpatrick, M. J.; Harding, E. G.; Rebba, S.; Ruzycki, P. A.; Kerschensteiner, D.
10.1101/2025.03.22.644712 — neuroscience — Posted on 2025-03-24
1256 High-Definition MEG Source Estimation using the Reciprocal Boundary Element Fast Multipole Method
Nunez Ponasso, G.; Drumm, D. A.; Wang, A.; Noetscher, G. M.; Hamalainen, M.; Knosche, T.; Maess, B.; Haueisen, J.; Makaroff, S. N.; Raij, T.
10.1101/2025.03.21.644601 — neuroscience — Posted on 2025-03-24
1261 Cerebellin-2 positive (Cbln2+) Neurons in the Parafascicular Thalamic Nucleus Regulate Self-Grooming Behavior
Zhang, L.; Song, H.; Li, Y.; Zhang, H.; Geng, D.; Zhao, Z.; Yang, B.; Zheng, R.; Li, Z.; Wang, L.; Zhang, T.; Xie, Z.; Cao, P.; Li, D.; Zhang, F.
10.1101/2025.03.22.644777 — neuroscience — Posted on 2025-03-24
1265 Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans
Iturria-Medina, Y.; Poole, V. N.; Zammit, A. R.; de Paiva Lopes, K.; Vialle, R. A.; Yu, L.; Tasaki, S.; Batalha, C.; Hong, J. H.; Sanchez-Rodriguez, L.; Geddes, M. R.; Abadir, P.; Ortlund, E. A.; De Jager, P.; Menon, V.; Schnaider Beeri, M.; Buchman, A. S.; Levin, Y.; Morgenstern, D.; Schneider, J. A.; Kaddurah-Daouk, R.; Wyss-Coray, T.; Seyfried, N.; Poulakis, K.; Rosa-Neto, P.; Wang, Y.; Bennett, D. A.
10.1101/2025.03.20.644323 — neuroscience — Posted on 2025-03-24
1267 Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring
Nguyen, D. M.; Monroe, S. K.; Rendina, D. N.; Boyd, K. S.; Rispoli, E. D.; Wirfel, O. M.; Campos-Salazar, A. B.; Araujo, A. R.; Vaidyanathan, T. V.; Keziah, V. L.; Devlin, B. A.; Smith, C. J.; Bilbo, S.
10.1101/2025.03.24.644910 — developmental biology — Posted on 2025-03-24
1268 Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines
Pavlinek, A.; Dutan-Polit, L.; Nagy, R.; APEX Consortia, ; Lancaster, M. A.; Vernon, A. C.; Srivastava, D. P.
10.1101/2025.03.24.644896 — neuroscience — Posted on 2025-03-24
1269 Altered Interpersonal Neural Synchronization during Social Interaction After Shared Excluded Experiences in Depressed Adolescents
He, Y.; Chen, J.; Lin, Y.; Chan, N.; Gao, F.; Liu, L.; Yin, X.; Sun, Y.; Li, M.; Zhang, S.; Wei, Z.; Yu, L.; Huang, X.; Su, Z.; Yuan, Z.
10.1101/2025.03.24.644779 — neuroscience — Posted on 2025-03-24
1274 Neural dynamics of induced vocal tract vibrations during vocal emotion recognition
Selosse, G.; Benis, D.; Greilsamer, J.; Meuleman, B.; Grandjean, D.; Ceravolo, L.
10.1101/2025.03.24.644945 — neuroscience — Posted on 2025-03-24
1275 Seizure-like behavior and hyperactivity in napb knockout zebrafish as a model for autism and epilepsy
Shin, K. C.; Hasan, W.; Ali, G.; Abdelrahman, D.; Abuarja, T.; Stanton, L. W.; Da'as, S. I.; Park, Y.
10.1101/2025.03.24.644881 — neuroscience — Posted on 2025-03-24
1276 Understanding the mechanism of facilitation in hoverfly TSDNs
Ghosh, A.; Nicholas, S.; Nordström, K.; Nowotny, T.; Knight, J.
10.1101/2025.03.24.644907 — neuroscience — Posted on 2025-03-24
1277 Light propofol anaesthesia for non-invasive auditory EEG recording in unrestrained non-human primates.
Piette, T.; Lacaux, C.; Scheltienne, M.; Sterpenich, V.; Isnardon, M.; Moulin, V.; Cermolacce, A.; Grandjean, D.; Meguerditchian, A.; Deaux, E.; Giraud, A.-L.
10.1101/2025.03.24.644890 — neuroscience — Posted on 2025-03-24
1281 PET-derived amyloid patterns in gray and white matter across Alzheimer's disease: A high-model-order ICA
Khasayeva, N.; Jensen, K. M.; Eierud, C.; Petropoulos, H.; Luo, R.; Premi, E.; Borroni, B.; Chen, J.; Calhoun, V.; Iraji, A.
10.1101/2025.03.21.644614 — neuroscience — Posted on 2025-03-24
1283 LSD reconfigures the frequency-specific network landscape of the human brain
Shinozuka, K.; Rosso, M.; Coleman, C. R.; Roseman, L.; Kaelen, M.; Muthukumaraswamy, S. D.; Nutt, D. J.; Carhart-Harris, R.; Vuust, P.; Kringelbach, M. L.; Bonetti, L.
10.1101/2025.03.21.644645 — neuroscience — Posted on 2025-03-24
1284 Diurnal dynamics of multilayer brain networks predict cognitive trajectories in aging
Bennis, K.; Canal-Garcia, A.; Pereira, J.; Volpe, G.; Eustache, F.; Phillips, C.; Bastin, C.; Collette, F.; Vandewalle, G.; Hinault, T. T.
10.1101/2025.03.24.644492 — neuroscience — Posted on 2025-03-24
1287 Application of Down-Phase Targeted Auditory Stimulation During Sleep in a Home Setting: A Feasibility Study Across Seven Consecutive Nights
Eicher, C.; Gallego Vazquez, C.; Schmid, C.; Kronenberg, G.; Landolt, H.-P.; Seifritz, E.; Da Poian, G.; Huber, R.
10.1101/2025.03.21.644521 — neuroscience — Posted on 2025-03-24
1290 Scale-dependent brain age with higher-order statisticsfrom structural magnetic resonance imaging
Carnero-Rosell, A.; Janssen, N.; Maselli, A.; Pereda, E.; Huertas-Company, M.; Kitaura, F.-S.
10.1101/2025.03.24.644902 — neuroscience — Posted on 2025-03-24
1291 Vertical Optokinetic Eye Movements in the Larval Zebrafish
Burkhardt, D.-S.; Moeller, G.; Deligand, L.; Fichtner, C.; Hladnik, T. C.; Arrenberg, A. B.
10.1101/2025.03.21.644542 — neuroscience — Posted on 2025-03-24
1298 Accounting for spatial interactions in the upscaling of ecosystem services
Boesing, A. L.; Le Provost, G.; Neyret, M.; Linstädter, A.; Muro, J.; Müller, J.; Jung, K.; Fischer, M.; Lange, M.; Dubovyk, O.; Magdon, P.; Bolliger, R.; Leimer, S.; Boch, S.; Renner, S.; Kleinebecker, T.; Hamer, U.; Klaus, V. H.; Wilcke, W.; Manning, P.
10.1101/2025.03.22.644705 — ecology — Posted on 2025-03-24
1300 Reconstitution of human fetal ovaries reveals niche requirements for primordial germ cell-like cell progression
Chang, Y. W.; Trimp, M.; van der Helm, T.; Blanch-Asensio, A.; Overeem, A. W.; Chuva de Sousa Lopes, S. M.
10.1101/2025.03.21.644608 — developmental biology — Posted on 2025-03-24
1302 Enhancing Embryo Stage Classification with Multi-Focal Plane Imaging and Deep Learning
Bechar, M. E. A.; Benfettoume Souda, A.; Marchadour, W.; Hamza-Cherif, S.; Guyader, J.-M.; Elbouz, M.; Morel, F.; Perrin, A.; Settouti, N.
10.1101/2025.03.21.644547 — developmental biology — Posted on 2025-03-24
1304 LEAFY demonstrates ancestral reproductive functions in the gametophyte and not the sporophyte of the fern Ceratopteris richardii
McConnell, H.; Lanclos, J. R.; Willis, K.; Gjording, N.; Stockmann, G.; Maloof, J. N.; Plackett, A. R. G.; Di Stilio, V. S.
10.1101/2025.03.21.644678 — developmental biology — Posted on 2025-03-24
1305 Automated, high-throughput in-situ hybridization of Lytechinus pictus embryos
Lee, Y.; Jenniches, C.; Metry, R.; Renaudin, G.; Kling, S.; Tjeerdema, E.; Jackson, E. W.; Hamdoun, A.
10.1101/2025.03.23.644641 — developmental biology — Posted on 2025-03-24
1306 Alternative splicing dynamics during human cardiac development in vivo and in vitro
Gomes-Silva, B.; Furtado, M.; Ribeiro, M.; Martins, S.; Carvalho, M. T.; Maatz, H.; Gotthardt, M.; Savisaar, R.; Carmo-Fonseca, M.
10.1101/2025.03.21.642423 — developmental biology — Posted on 2025-03-24
1309 Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns
Schneeberger, P. H. H.; Dommann, J.; Rahman, N. O.; Huerlimann, E.; Sayasone, S.; Ali, S. M.; Coulibaly, J. T.; keiser, J.
10.1101/2025.03.21.641387 — microbiology — Posted on 2025-03-24
1310 PhotoNeuro: A compact photodetector for synchronization of visual stimulus presentation during behavioral experiments in neuroscience.
Cano Ferrer, X.; Moglie, M. J.; Konstantinou, G.; Blot, A.; Bianchini, G.; Imbert, A.; Znamenskiy, P.; Iacaruso, M. F.
10.1101/2025.03.22.644703 — neuroscience — Posted on 2025-03-24
1311 FAIRification of computational models in biology
Balaur, I.; Nickerson, D. P.; Welter, D.; Wodke, J. A. H.; Ancien, F.; Gebhardt, T.; Groues, V.; Hermjakob, H.; Konig, M.; Radde, N.; Rougny, A.; Schneider, R.; Malik Sheriff, R. S.; Shiferaw, K. B.; Stefan, M.; Satagopam, V. P.; Waltemath, D.
10.1101/2025.03.21.644517 — systems biology — Posted on 2025-03-24
1318 Cell-Surface RNA Forms Ternary Complex with RNA-Binding Proteins and Heparan Sulfate to Recruit Immune Receptors
Li, Z.; Joshi, B. S.; Yin, H.; Wijdeven, R. H.; Koc, R. A.; Zijlman, D. W.; Pataskar, A.; Santos-Barriopedro, I.; Mei, H.; Wu, W.; Shademan, M.; Bos, E.; Zawisza, F. M.; Chopra, P.; Tanenbaum, M.; Sharp, T.; Vermeulen, M.; Raz, V.; Joo, C.
10.1101/2024.07.23.604836 — molecular biology — Posted on 2025-03-24
1324 MicroCT-Based Imaging of Microvasculature in Bone and Peri-Implant Tissues
Haberthür, D.; Khoma, O.-Z.; Hoessly, T.; Zoni, E.; Kruithof-de Julio, M.; Ryan, S. D.; Grunewald, M.; Bellon, B.; Sandgren, R.; Pippenger, B. E.; Bosshardt, D.; Djonov, V.; Hlushchuk, R.
10.1101/2023.03.08.531678 — physiology — Posted on 2025-03-24
1325 AP-1 regulates heterogeneous cellular dormancy in TNBC
Dong, Y.; Bai, J.; Fu, R.; Su, H.; Wu, S.; Liu, R. N.; Tang, D. G.; Zhou, J.
10.1101/2023.11.22.566980 — cancer biology — Posted on 2025-03-24
1329 Structural conformations of intrinsically disordered proteins of podocyte slit-diaphragm
Padmanaban, H. K.; Bheemireddy, S.; Mulukala, S. K.; Dunna, N. R.; Pasupulati, A. k.
10.1101/2025.03.04.641475 — bioinformatics — Posted on 2025-03-24
1330 nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome
Dagher, M.; Ongo, G.; Robichaud, N.; Kong, J.; Rho, W.; Teahulos, I.; Tavakoli, A.; Bovaird, S.; Merjaneh, S.; Tan, A.; Edwardson, K.; Scheepers, C.; Ng, A.; Hajjar, A.; Sow, B.; Vrouvides, M.; Lee, A.; DeCorwin-Martin, P.; Rasool, S.; Huang, J.; Han, Y.; Erps, T.; Coffin, S.; Chandrasekaran, S. N.; Miller, L.; Kost-Alimova, M.; Skepner, A.; Singh, S.; Carpenter, A. E.; Munzar, J.; Juncker, D.
10.1101/2023.04.17.535914 — bioengineering — Posted on 2025-03-24
1331 Hydrogen-Induced Calcium Influx via the TRPC4-TRPC4AP Axis
Zhao, P.; Li, H.; Cai, Z.; Zhang, X.; Wen, X.; Liu, Z.; Jiang, S.; Dang, Z.; Jiang, X.; Wang, J.; Liu, M.; Xie, F.; Ma, X.
10.1101/2025.03.19.644243 — biochemistry — Posted on 2025-03-24
1332 Human Body Single-Cell Atlas of 3D Genome Organization and DNA Methylation
Zhou, J.; Wu, Y.; Liu, H.; Tian, W.; Castanon, R. G.; Bartlett, A.; Zhang, Z.; Yao, G.; Shi, D.; Clock, B.; Marcotte, S.; Nery, J. R.; Liem, M.; Claffey, N.; Boggeman, L.; Barragan, C.; eDrigo, R. A.; Weimer, A. K.; Shi, M.; Cooper-Knock, J.; Zhang, S.; Snyder, M. P.; Preissl, S.; Ren, B.; O'Connor, C.; Chen, S.; Luo, C.; Dixon, J. R.; Ecker, J. R.
10.1101/2025.03.23.644697 — genomics — Posted on 2025-03-24
1333 Genetic underpinnings of chills from art and music
Bignardi, G.; Admiraal, D.; Eising, E.; Fisher, S. E.
10.1101/2025.03.24.644874 — genetics — Posted on 2025-03-24
1338 Promising effects of duck vaccination against highly pathogenic avian influenza, France 2023-24
Guinat, C.; Fourtune, L.; Lambert, S.; Martin, E.; Gerbier, G.; Jimenez Pellicer, A.; Guerin, J.-L.; Vergne, T.
10.1101/2024.08.28.609837 — ecology — Posted on 2025-03-24
1340 Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development
Chung, E.; Nosrati, F.; Adam, M.; Potter, A.; Sayed, M.; Ahn, C.; Humphreys, B.; Lim, H.-W.; Hu, Y.-C.; Potter, S. S.; Park, J.-S.
10.1101/2025.01.14.633065 — developmental biology — Posted on 2025-03-24
1341 Glioblastoma stem cell morphotypes convey distinct cell states and clinically relevant functions
Barelli, C.; Bonfanti, M.; Mirabella, F.; Ricca, D.; Alizadehmohajer, N.; Sokolova, V.; Campione, A.; Sicuri, G. M.; Peano, C.; Faletti, S.; Stefini, R.; Kalebic, N.
10.1101/2025.03.24.644884 — cell biology — Posted on 2025-03-24
1342 Fibrillarin shapes oncogenic protein pools and ribosomal composition in triple-negative breast cancer
Groza, P.; Kumari, K.; Schott, J.; Esteva-Socias, M.; Destefanis, E.; Peula, C.; Williams, C.; Marchand, V.; Wikstrom, P.; Wiberg, R.; Bosch, A.; Gilthorpe, J. D.; Pop, B.; Mateus, A.; Motorin, Y.; Dassi, E.; Tuorto, F.; Aguilo, F.
10.1101/2025.03.21.644506 — molecular biology — Posted on 2025-03-24
1344 LILRA5 functions to induce ROS production on innate immune cells
Fu, Z.; Rumpret, M.; Kube-Golovin, I.; Lyndin, M.; Solntceva, V.; Zhao, Y.; Konieva, A.; Liu, N.; Press, A.; Flohe, S.; Bauer, M.; Wennemuth, G.; Singer, B. B.; McCarthy, A. J.
10.1101/2025.03.16.643524 — immunology — Posted on 2025-03-24
1347 Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction
Ibrahim, M. F.; Boyanova, S.; Cheng, Y. C.; Ligneul, C.; Bains, R. S.; Lerch, J. P.; Mann, E. O.; Oliver, P. L.; Becker, E. B. E.
10.1101/2025.03.24.644877 — neuroscience — Posted on 2025-03-24
1352 Calcium-based input timing learning
Kamalabad, S. S.; Schmitt, S.; Tetzlaff, C.
10.1101/2024.11.14.623617 — neuroscience — Posted on 2025-03-24
1353 Polyadenylation landscape of in vivo long-term potentiation in the rat brain
Guminska, N.; Pauzin, F. P.; Kuzniewska, B.; Miłek, J.; Wardaszka, P.; Krawczyk, P. S.; Mroczek, S.; Jelen, S.; Pagenhart, P. U.; Bramham, C. R.; Dziembowska, M.; Dziembowski, A.
10.1101/2024.06.05.597605 — neuroscience — Posted on 2025-03-24
1354 DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids
McNerney, C.; Santiago, C.; Eldred, K. C.; Glass, I.; Reh, T. A.; Hernandez, A.; Blackshaw, S.; Lord, N.; Johnston, R. J.
10.1101/2025.03.20.644422 — developmental biology — Posted on 2025-03-24
1360 Estrous cycle stage gates the effect of stress on reward learning
Johnston, M. P.; Garcia-Castaneda, B. I.; Cedillo, L. G.; Patel, S. K.; Vargas, V. S.; Wanat, M. J.
10.1101/2025.03.23.644830 — neuroscience — Posted on 2025-03-24
1368 Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes
Liu, C.; Liu, D.; Zheng, X.; Guan, J.; Zhou, X.; Zhang, H.; Wang, S.; Li, Q.; Gan, L.; He, J.; Ma, C.
10.1101/2025.03.22.644518 — cell biology — Posted on 2025-03-24
1370 A novel membrane contact site in vestibular hair cells
Brouilly, N.; Pujol, N.; Richard, F.; Cazevieille, C.; Stone, J. S.; Eatock, R. A.; Pujol, R.
10.1101/2025.03.21.644540 — neuroscience — Posted on 2025-03-24
1372 Mapping Along-Tract White Matter Microstructural Differences in Autism
Kim, G. S.; Chandio, B. Q.; Benavidez, S. M.; Feng, Y.; Thompson, P. M.; Lawrence, K. E.
10.1101/2025.03.21.644498 — neuroscience — Posted on 2025-03-24
1373 Decoding the molecular complexity governing corneal wound closure in vivo
Feret, N.; Caballero Megido, A.; Kalha, S.; Kuony, A.; Fichter, L.; Llorens Garcia, S.; Attina, A.; Nhiri, N.; Jacquet, E.; Viaralet, J.; David, A.; Hirtz, C.; Loulier, K.; Michon, F.
10.1101/2025.03.20.642766 — physiology — Posted on 2025-03-23
1374 Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Watts, D.; Eberz, N.; Jaykar, M. T.; Sinha, A.; Ermis, C.; Tiebel, J.; Baschant, U.; Rauner, M.; Grinenko, T.; Chavakis, T.; Mirtschink, P.; El-Armouche, A.; Wielockx, B.
10.1101/2025.03.20.644292 — immunology — Posted on 2025-03-23
1375 Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction
Sharifzadeh, A. S.; Castelli, R.; Porro, A.; Mesirca, P.; Perrier, R.; Gomez, A. M.; Benoit, H.; Meli, A. C.; Palloni, L. M. G.; DiFrancesco, D.; Mangoni, M. E.; Thiel, G.; Saponaro, A.; Moroni, A.
10.1101/2025.03.20.644287 — biophysics — Posted on 2025-03-23
1376 Prior epigenetic status predicts future susceptibility to seizures in mice
Boros, B. D.; Gachechiladze, M. A.; Guo, J.; Galloway, D. A.; Mueller, S. M.; Shabsovich, M.; Yen, A.; Cammack, A. J.; Shen, T.; Mitra, R. D.; Dougherty, J. D.; Miller, T. M.
10.1101/2025.03.20.644199 — genomics — Posted on 2025-03-23
1377 Gene expression analysis of carbohydrate catabolism in Leucoagaricus gongylophorus LEU18496.
Castillo-Alfonso, F.; Cejas-Anon, G.; Valadez-Cano, C.; Sigala Alanis, J. C.; Vigueras-Ramirez, G.; Olivares-Hernandez, R.
10.1101/2025.03.21.644473 — genomics — Posted on 2025-03-23
1379 The rise, decline and fall of clades
Quintero, I.; Andreoletti, J.; Silvestro, D.; Morlon, H.
10.1101/2025.03.20.644316 — evolutionary biology — Posted on 2025-03-23
1380 Higher ploidy coincides with inferior performance and no difference in stress tolerance in reed
Haldan, K.; Kuprina, K.; Duesterhoeft, C.; Eller, F.; Fiehn, A.; Garthen, A.; Krauss, N.; Schnittler, M.; Bog, M.; Kreyling, J.
10.1101/2025.03.20.644296 — ecology — Posted on 2025-03-23
1381 Five years of high-frequency data of phytoplankton zooplankton and limnology from a temperate eutrophic lake
Eyring, S.; Reyes, M.; Ewa, M.; Baity-Jesi, M.; Ntesika, P.; Ebi, C.; Dennis, S.; Pomati, F.
10.1101/2025.03.20.644357 — ecology — Posted on 2025-03-23
1382 ecDNA replication is disorganised and vulnerable to replication stress
Jaworski, J. J.; Pfuderer, P. L.; Czyz, P.; Petris, G.; Boemo, M. A.; Sale, J.
10.1101/2025.03.22.644567 — cancer biology — Posted on 2025-03-23
1387 SMART platform for enzyme engineering: A novel single-molecule display approach for evolution and functional studies of D-amino acid oxidase
Munaweera, K.; Odake, N.; Ikeda, K.; Zhu, B.; Camagna, M.; Ito, T.; Kitaguchi, T.; Nemoto, N.; Nakano, H.; Damnjanovic, J.
10.1101/2025.03.23.644798 — bioengineering — Posted on 2025-03-23
1391 Accessible, realistic genome simulation with selection using stdpopsim
Gower, G.; Pope, N. S.; Rodrigues, M. F.; Tittes, S.; Tran, L. N.; Alam, O.; Cavassim, M. I. A.; Fields, P. D.; Haller, B. C.; Huang, X.; Jeffrey, B.; Korfmann, K.; Kyriazis, C. C.; Min, J.; Rebollo, I.; Rehmann, C. T.; Small, S. T.; Smith, C. C. R.; Tsambos, G.; Wong, Y.; Zhang, Y.; Huber, C. D.; Gorjanc, G.; Ragsdale, A.; Gronau, I.; Gutenkunst, R. N.; Kelleher, J.; Lohmueller, K. E.; Schrider, D. R.; Ralph, P. L.; Kern, A. D.
10.1101/2025.03.23.644823 — evolutionary biology — Posted on 2025-03-23
1394 De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Muratspahic, E.; Feldman, D.; Kim, D. E.; Qu, X.; Bratovianu, A.-M.; Rivera-Sanchez, P.; Dimitri, F.; Cao, J.; Cary, B. P.; Belousoff, M. J.; Keov, P.; Chen, Q.; Ren, Y.; Fine, J.; Sappington, I.; Schlichthaerle, T.; Zhang, J. Z.; Pillai, A.; Mihaljevic, L.; Bauer, M.; Torres, S. V.; Motmaen, A.; Lee, G. R.; Tran, L.; Wang, X.; Goreshnik, I.; Vafeados, D. K.; Svendsen, J. E.; Hosseinzadeh, P.; Lindegaard, N.; Brandt, M.; Waltenspühl, Y.; Deibler, K.; Oostdyk, L.; Cao, W.; Anantharaman, L.; Stewart, L.; Halloran, L.; Spangler, J. B.; Sexton, P. M.; Roth, B. L.; Krumm, B. E.; Wootten, D.; Tate,
10.1101/2025.03.23.644666 — bioengineering — Posted on 2025-03-23
1397 Flagellar pocket collar biogenesis: Cytoskeletal organization and novel structures in a unicellular parasite
Zelena, M.; Casas, E.; Lambert, C.; Landrein, N.; Dacheux, D.; Abesamis, K. I.; Dong, G.; Varga, V.; Robinson, D. R.; BONHIVERS, M.
10.1101/2025.03.23.644790 — microbiology — Posted on 2025-03-23
1398 Hyphal growth determines spatial organization and coexistence in a pathogenic polymicrobial community within alveoli-like geometries
Mancini, L.; Saliekh, L.; Claydon, R.; Kotar, J.; Benyei, E. B.; Munro, C. A.; Shendruk, T. N.; Brown, A.; Welch, M.; Cicuta, P.
10.1101/2025.03.22.644766 — microbiology — Posted on 2025-03-23
1401 Common non-antibiotic drugs enhance selection for antimicrobial resistance in mixture with ciprofloxacin
Hayes, A.; Zhang, L.; Snape, J.; Feil, E.; Kasprzyk-Hordern, B.; Gaze, W. H.; Murray, A. K.
10.1101/2025.03.23.644574 — microbiology — Posted on 2025-03-23
1402 WarpDemuX-tRNA: barcode multiplexing for nanopore tRNA sequencing
van der Toorn, W.; Naarmann-de Vries, I. S.; Liu-Wei, W.; Dieterich, C.; von Kleist, M.
10.1101/2025.03.21.644602 — bioinformatics — Posted on 2025-03-23
1403 NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells
Cook, M.; Smailys, J.; Ji, K.; Phelps, S.; Tutol, J.; Kim, W.; Ong, W.; Peng, W.; Maydew, C.; Zhang, Y.; Dodani, S. C.
10.1101/2025.03.22.644677 — biochemistry — Posted on 2025-03-23
1405 Comparative genomic analysis of a metagenome-assembled genome reveals distinctive symbiotic traits in a Mucoromycotina fine root endophyte arbuscular mycorrhizal fungus
Cole, J.; Raguideau, S.; Abbaszadeh-Dahaji, P.; Hilton, S.; Muscatt, G.; Mushinski, R. M.; Nilsson, R. H.; Ryan, M. H.; Quince, C.; Bending, G. D.
10.1101/2024.11.27.625642 — microbiology — Posted on 2025-03-23
1406 Sequence action representations contextualize during early skill learning
Dash, D.; Iwane, F.; Hayward, W.; Salamanca-Giron, R.; Bonstrup, M.; Buch, E.; Cohen, L.
10.1101/2024.08.15.608189 — neuroscience — Posted on 2025-03-23
1408 Comprehensive profiling of N6-methyladnosine (m6A) readouts reveals novel m6A readers that regulate human embryonic stem cell differentiation
Huang, Z.; Liu, R.; Wubulikasimu, Z.; Zhao, W.; Huang, J.; Wang, J.; Fan, R.; Kong, W.; Cui, Q.; Li, Y.; Zhou, Y.
10.1101/2025.03.09.640963 — genomics — Posted on 2025-03-23
1410 Fibrillarin shapes oncogenic protein pools and ribosomal composition in triple-negative breast cancer
Groza, P.; Kumari, K.; Schott, J.; Esteva-Socias, M.; Destefanis, E.; Peula, C.; Williams, C.; Marchand, V.; Wikstrom, P.; Wiberg, R.; Bosch, A.; Gilthorpe, J. D.; Pop, B.; Mateus, A.; Motorin, Y.; Dassi, E.; Tuorto, F.; Aguilo, F.
10.1101/2025.03.21.644506 — molecular biology — Posted on 2025-03-23
1412 Unveiling the Unique Structure and Singular Function of the Histone Deacetylase 2 (TgHDAC2) of Toxoplasma gondii
de Moraes de Siqueira, C.; Zamith Schwartz, J.; Galvao Ferrarini, M.; Fragoso, M. S. I.; Ronalte Alves, L.; Rodrigues Avila, A.; de Arruda Campos Brasil de Souza, T.; Nardelli, S. C.
10.1101/2025.03.21.644624 — microbiology — Posted on 2025-03-23
1415 Microbial community characteristics and stable relationships centered on anammox bacteria revealed by global-scale analysis
Wang, Y.-C.; Fu, H.-M.; Liu, H.-Y.; Wu, H.; Zeng, Z.-H.; He, J.-H.; Gao, M.-J.; Yan, P.; Zhang, L.; Chen, Y.-P.
10.1101/2025.03.21.644508 — microbiology — Posted on 2025-03-23
1416 The impact of heterogeneous spatial autocorrelation on comparisons of brain maps
Leech, R.; Smallwood, J. S.; Moran, R.; Jones, E. J.; Nicholas, V.; Leech, D.; Viegas, E. M.; Turkheimer, F. E.; Alberti, F.; Margulies, D.; Jefferies, E.; Zhou, Y.; Alexander-Bloch, A.; Bernhardt, B.; Vasa, F.
10.1101/2024.06.14.598987 — neuroscience — Posted on 2025-03-23
1417 Early Detection and Quantification of Fusarium Wilt in Greenhouse-Grown Tomato Plants Using Water-Relation Measurements
Friedman, S.; Dalal, A.; Batat, D.; Burdman, S.; Sela, Y.; Hipsch, M.; Rosenwaser, S.; Marcos Hadad, E.; Covo, S.; Moshelion, M.
10.1101/2024.02.11.579801 — plant biology — Posted on 2025-03-23
1418 Structural conformations of intrinsically disordered proteins of podocyte slit-diaphragm
Padmanaban, H. K.; Bheemireddy, S.; Mulukala, S. K.; Dunna, N. R.; Pasupulati, A. k.
10.1101/2025.03.04.641475 — bioinformatics — Posted on 2025-03-23
1420 Reconstructing the Single-Cell Spatiotemporal Dynamics of Glioblastoma Invasion
Mangukiya, H. B.; Skeppas, M.; Kundu, S.; Berglund, M.; Malik, A. A.; Krona, C.; Nelander, S.
10.1101/2025.03.20.644331 — cancer biology — Posted on 2025-03-22
1423 MAIS: an in-vitro sandbox enables adaptive neuromodulation via scalable neural interfaces
Chen, H.; Chen, F.; Chen, X.; Liu, Y.; Xu, J.; Li, J.; Bao, X.; Chen, Y.; Sun, H.; Jiang, J.; Ye, F.; Su, J.; Gen, Y.; Ye, F.; Wang, Z.; Liu, L.; Hexige, S.; Li, X.; Ma, L.; Shuai, J.
10.1101/2025.03.15.641656 — bioengineering — Posted on 2025-03-22
1424 Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Forrest, I.; Conway, L. P.; Jadhav, A. M.; Gathmann, C.; Chiu, T.-Y.; Chaheine, C. M.; Estrada, M.; Shrestha, A.; Reitsma, J.; Warder, S. E.; Vasudevan, A.; McLoughlin, S. M.; Parker, C. G.
10.1101/2025.03.21.644652 — biochemistry — Posted on 2025-03-22
1425 Local control of cellular proliferation underlies neuromast regeneration in zebrafish
Lavalle, N. G.; Miranda, J.; Cura Costa, E.; Borges, A.; Viader-Llargues, O.; Lopez Schier, H.; Chara, O.
10.1101/2024.10.22.619208 — developmental biology — Posted on 2025-03-22
1427 Development and validation of five native Aotearoa New Zealand genera-specific large brown macroalgal eDNA ddPCR assays
Deinhart, M.; Brooks, A.; Smith, L.; D'Archino, R.; Hickson, R.; Zuccarello, G. c.; Nodder, S.; Bilewitch, J.
10.1101/2025.03.21.644472 — molecular biology — Posted on 2025-03-22
1428 A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite
Baumgarten, S.; Couble, J.; Vignolini, T.; Dore, G.; Lombard, B.; Loew, D.; Richard, M.; Buettner, M.; Poschet, G.; Duenas Sanchez, R.; Bryant, J. M.
10.1101/2025.03.22.644534 — microbiology — Posted on 2025-03-22
1430 Pollinator-relevant floral traits underlie bidirectional hybridisation in the orchid genus Gymnadenia
Neequaye, M.; Kellenberger, R. T.; Collier, R.; Paajanen, P.; Antoniou-Kourounioti, R.; Wenzell, K.; Hill, L.; Schluter, P. M.; Byers, K. J. R. P.
10.1101/2025.03.20.644302 — plant biology — Posted on 2025-03-22
1431 Active learning for improving out-of-distribution lab-in-the-loop experimental design
Balashova, D.; Frank, R.; Kuzyakina, S.; Weltevreden, D.; Robert, P. A.; Sandve, G. K.; Greiff, V.
10.1101/2025.02.26.640110 — bioinformatics — Posted on 2025-03-22
1433 Protocol Optimization Improves the Performance of Multiplexed RNA Imaging
Luce, J. J.; Reardon-Lochbaum, C. A.; Cadinu, P.; Xu, R. J.; Aceves-Salvador, J.; Semizoglou, E.; Wong, B.; Lopez, I.; Cantor, A. B.; Renthal, W.; Moffitt, J. R.
10.1101/2025.03.21.644527 — genomics — Posted on 2025-03-22
1435 A mouse model of Adams-Oliver Syndrome reveals defective Notch1 signaling in endothelial cells as a driver of pathogenesis
Solano, A.; Preusse, K.; Cain, B.; Hotz, R.; Gavini, P.; Yuan, Z.; Bowen, B.; Maco, G.; Neal, H.; Gagliani, E. K.; Southgate, L.; Kovall, R.; Kopan, R.; Gebelein, B.
10.1101/2025.03.20.644338 — developmental biology — Posted on 2025-03-22
1436 Bacterial ubiquitin ligase engineered for small molecule and protein target identification
Ye, J. S.; Majumdar, A.; Park, B. C.; Black, M. H.; Hsieh, T.-S.; Osinski, A.; Servage, K. A.; Kulkarni, K.; Naidoo, J.; Alto, N. M.; Stratton, M. M.; Alfandari, D.; Ready, J. M.; Pawłowski, K.; Tomchick, D. R.; Tagliabracci, V. S.
10.1101/2025.03.20.644192 — molecular biology — Posted on 2025-03-22
1438 Single-cell proteomics workflow for characterizing heterogeneous cell populations in saliva and tear fluid
Miyamoto, J. G.; Amaral-Prado, H. M. d.; Patroni, F. M. d. S.; Telles, G. P.; Moretto Carnielli, C.; Camara, G. A.; de Figueiredo, D.; Cardoso, E. C.; Granato, D. C.; Santos-Silva, A. R.; Lopes, M. A.; Paes Leme, A.
10.1101/2025.03.21.644566 — molecular biology — Posted on 2025-03-22
1442 Inhibition of IL-22-producing cells by Sutterella sp. bacteria
Dupraz, L.; Orianne, G.; Da Costa, G.; Gauthier, R.; Blondeau, A.; Boinet, M.; Creusot, L.; Magniez, A.; Chollet, L.; Rolhion, N.; Danne, C.; Dvorak, Z.; Seksik, P.; Sokol, H.; Michel, M.-L.
10.1101/2025.03.20.644103 — immunology — Posted on 2025-03-22
1443 Detection of Pre-Existing Immunity to Bacterial Cas9 Proteins in People with Cystic Fibrosis
Serpa, G.; Gong, Q.; De, M.; Rana, P. S. J. B.; Montgomery, C. P.; Wozniak, D. J.; Long, M. E.; Hemann, E. A.
10.1101/2025.03.20.644396 — immunology — Posted on 2025-03-22
1444 Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza.
Pingen, M.; Hughes, C.; Medina-Ruiz, L.; Mathie, H.; Barrie, J.; Hansell, C.; Bartolini, R.; MacLeod, M. K.; Graham, G. K.
10.1101/2025.03.20.644330 — immunology — Posted on 2025-03-22
1448 A GENERALIZED PROTEIN DESIGN ML MODEL ENABLESGENERATION OF FUNCTIONAL DE NOVO PROTEINS
Riley, T. P.; Matusovsky, O.; Parsa, M. S.; Kalantari, P.; Naderi, I.; Azimian, K.; Wei, K. Y.
10.1101/2025.03.21.644400 — biochemistry — Posted on 2025-03-22
1450 A non-coding role for trypanosome VSG transcripts in allelic exclusion
Horn, D.; Escrivani, D.; Hutchinson, S.; Tinti, M.; Wright, J.; Marques, C.; Faria, J. R.; Trenaman, A.
10.1101/2025.03.21.644657 — molecular biology — Posted on 2025-03-22
1454 GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer
Kito, Y.; Gonzalez-Robles, T. J.; Kaisari, S.; Pae, J.; Garcia, S. F.; Ortiz-Pacheco, J.; Ueberheide, B.; Lehmann, R.; Marzio, A.; Rona, G.; Pagano, M.
10.1101/2025.03.18.643855 — cell biology — Posted on 2025-03-22
1456 Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation
Das, T.; Zaidi, F.; Farag, M.; Ruff, K. M.; Mahendran, T. S.; Singh, A.; Gui, X.; Messing, J.; Taylor, J. P.; Banerjee, P. R.; Pappu, R. V.; Mittag, T.
10.1101/2024.02.28.582569 — biophysics — Posted on 2025-03-22
1458 Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interaction
Santamaria, C.; Biegas, K. J.; Lim, P. N.; Cabral, J.; Kim, C. Y.; Lee, J. R.; Gaidhane, I. V.; Papson, C.; Gomard-Henshaw, K.; Rothchild, A. C.; Swarts, B. M.; Siegrist, M. S.
10.1101/2024.12.16.627577 — microbiology — Posted on 2025-03-22
1461 Resting-State EEG Aperiodic Exponent Moderates the Association Between Age and Memory Performance in Older Adults
Campbell, A. J.; Anijärv, T. E.; Johansson, M.; Pace, T.; Lagopoulos, J.; Hermens, D. F.; Levenstein, J. M.; Andrews, S. C.
10.1101/2025.03.20.643891 — neuroscience — Posted on 2025-03-22
1462 The importance of small island populations for the long term survival of endangered large-bodied insular mammals
Aninta, S. G.; Drinkwater, R.; Carmagnini, A.; Deere, N. J.; Priyono, D. S.; Andayani, N.; Winarni, N. L.; Supriatna, J.; Fumagalli, M.; Larson, G.; Galbusera, P.; Macdonald, A.; Greer, D.; Mohamad, K.; Prasetyaningtyas, W. E.; Mustari, A. H.; Williams, J.; Barnett, R.; Shaw, D.; Semiadi, G.; Burton, J.; Seaman, D.; Voigt, M.; Struebig, M.; Brace, S.; Rossiter, S.; Frantz, L.
10.1101/2024.05.23.595221 — evolutionary biology — Posted on 2025-03-22
1463 A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon
Chen, X.; Raghunathan, K.; Bao, B.; Ngwa, E.; Kwong, A.; Wu, Z.; Babcock, S.; Baek, C.; Ye, G.; Muppirala, A.; Peng, Q.; Rutlin, M.; Bhaumik, M.; Yang, D.; Kotlarz, D.; Jadhav, U.; Rao, M.; Weerapana, E.; Zhou, X.; Ordovas-Montanes, J.; Snapper, S. B.; Thiagarajah, J. R.
10.1101/2025.01.26.634856 — cell biology — Posted on 2025-03-22
1464 Utility of the Recombinase Driver CX3CR1::Cre Rat Strain to Evaluate Microglial Contributions to Nicotine Addiction
White, A. M.; Craig, A. J.; Richie, D. L.; Corley, C. L.; Bondy, E. O.; Kendrick, P. T.; McManus, H.; Sadek, S. M.; Scofield, M. D.; Gipson, C. D.
10.1101/2025.03.18.643780 — neuroscience — Posted on 2025-03-22
1465 Single VLP lipid-mixing measurements confirm off-pathway state in dengue virus fusion mechanism
Anika, T. K.; Campbell, F.; Linden, B.; Criswell, C. J.; Kimm, M.; Li-ning Yang, P.; Rawle, R. J.
10.1101/2025.03.21.644571 — biophysics — Posted on 2025-03-22
1467 Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules
Bielskute, S.; Mateos, B.; Awawdy, M.; Garcia-Cabau, C.; Niskanen, H.; Sanchez-Zarzalejo, C.; Bracaglia, L.; Pierattelli, R.; Felli, I. C.; Frigole-Vivas, M.; Garcia, J.; Riera, A.; Hnisz, D.; Salvatella, X.
10.1101/2025.03.21.644603 — biophysics — Posted on 2025-03-22
1469 The Legionella pneumophila peptidoglycan recycling kinase, AmgK, is essential for survival and replication inside host alveolar macrophages
Ratna, S.; Pradhan, L.; Vasconcelos, M. P.; Acharya, A.; Carnahan, B.; Wang, A.; Ghosh, A.; Bolt, A.; Ellis, J.; Hyland, S. N.; Hillman, A. S.; Fox, J. M.; Kloxin, A.; Neunuebel, M. R.; Grimes, C. L.
10.1101/2025.03.21.644609 — microbiology — Posted on 2025-03-22
1471 Machine Learning-based Identification and Characterization of High-risk Carriers of HTLV-1-Associated Myelopathy (HAM)
Rashid, M. I.; Sunagawa, J.; Matsuki, A.; Watanabe, T.; Iwanaga, M.; Koh, K.-R.; Yamada, A.; Shichijo, T.; Matsuoka, M.; Yasunaga, J.-i.; Nakaoka, S.
10.1101/2025.03.17.643639 — systems biology — Posted on 2025-03-22
1472 LetA defines a structurally distinct transporter family involved in lipid trafficking
Santarossa, C. C.; Li, Y.; Yousef, S.; Hasdemir, H. S.; Rodriguez, C. C.; Haase, M. B.; Baek, M.; Coudray, N.; Pavek, J. G.; Focke, K. N.; Silverberg, A. L.; Bautista, C.; Yeh, J.; Marty, M.; Baker, D.; Tajkhorshid, E.; Ekiert, D. C.; Bhabha, G.
10.1101/2025.03.21.644421 — biophysics — Posted on 2025-03-22
1473 Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region
Otsuki, T.; Matsumoto, S.; Fujita, J.; Miyata, T.; Namba, K.; Kanada, R.; Okuno, Y.; Kamada, H.; Ohno, H.; Akiba, H.
10.1101/2025.02.11.637430 — biochemistry — Posted on 2025-03-22
1475 A Tale of Two Parasites: A Glimpse into the clinical RNA Methylome of Plasmodium falciparum and Plasmodium vivax isolates
Roy, P.; Gujarati, S.; Gupta, P.; Gupta, I.; Mahapatra, T.; Gupta, D.; Kochar, S. K.; Kochar, D. K.; Das, A.
10.1101/2023.12.26.573234 — genomics — Posted on 2025-03-22
1477 Exosomes Released from Senescent Cells and Circulatory Exosomes Isolated from Human Plasma Reveal Aging-associated Proteomic and Lipid Signatures
Patel, S. K.; Bons, J.; Rose, J. P.; Chappel, J. R.; Beres, R. L.; Watson, M.; Webster, C.; Burton, J. B.; Bruderer, R.; Desprez, P. Y.; Reiter, L.; Campisi, J.; Baker, E.; Schilling, B.
10.1101/2024.06.22.600215 — cell biology — Posted on 2025-03-22
1478 Transcriptomic analysis of whole staged ovarian follicles reveals stage-specific folliculogenesis signatures in mice
VanBenschoten, H.; Chen, Y.-Y.; Kholod, O.; Russo, D. D.; Shalek, A. K.; Duncan, F. E.; Woodruff, T. K.; Goods, B. A.
10.1101/2025.03.20.644278 — bioinformatics — Posted on 2025-03-22
1479 Genomic rearrangements promote diversification of a facultative meiotic parthenogenetic nematode pest (Meloidogyne graminicola)
Phan Thi, N.; Danchin, E. G. J.; Koutsovoulos, G. D.; Rancurel, C.; Vermeire, M.-l.; Besnard, G.; Bellafiore, S.
10.1101/2025.03.20.644268 — genomics — Posted on 2025-03-22
1480 Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming.
Vu, H.; Sun, Y.; Xiong, Z.; Radford-Smith, D. E.; Causer, A.; Nefzger, C.; O'Sullivan, E.; Watt, M. J.; Ramm, G.; Clouston, A.; Irvine, K.; Nguyen, Q.; Powell, E.
10.1101/2025.03.20.644239 — genomics — Posted on 2025-03-22
1481 Protamine sequence determines species-specific nuclear shape and histone retention
Czernik, M.; Palazzese, L.; Winiarczyk, D.; Iuso, D.; Khochbin, S.; Fulka, J.; Fulka, H.; Villafranca, R.; Rielo, J. A.; Sanchez-Rodriguez, A.; Latorre, N.; Agudo-Rios, C.; Roldan, E.; Teves, M. E.; Loi, P.
10.1101/2025.03.20.644273 — developmental biology — Posted on 2025-03-22
1484 Brain structural modules associated to functional high-order interactions in the human brain,
Camino-Pontes, B.; Jimenez-Marin, A.; Tellaetxe-Elorriaga, I.; Fernandez-Iriondo, I.; Erramuzpe, A.; Diez, I.; Bonifazi, P.; Gatica, M.; Rosas, F. E.; Marinazzo, D.; Stramaglia, S.; Cortes, J.
10.1101/2025.03.21.644509 — neuroscience — Posted on 2025-03-21
1485 Auditory Perception Induces Cortical and Thalamic Event-Related Desynchronization in the Mouse
McGill, S. H.; Xin, Q.; Yadav, T.; Zhao, C. W.; Paszkowski, P.; Darby, F.; Guha, M.; Nguyen, T.; Jin, D. S.; Nir, Y.; Liu, J.; Sieu, L.-A.; Blumenfeld, H.
10.1101/2025.03.21.644604 — neuroscience — Posted on 2025-03-22
1486 Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation
Hathazi, D.; Lyons, C.; Lagos, D.; Podmanicky, O.; Zarate-Mendez, M.; Nie, N.; Mueller, J.; Allison, K.; lako, m.; Morava-Kozicz, E.; Kozicz, T.; Chinnery, P. F.; Lakatos, A.; Horvath, R.
10.1101/2025.03.21.644499 — neuroscience — Posted on 2025-03-22
1490 Three-photon population imaging of subcortical brain regions
Frostig, H.; Monasterio, A.; Xia, H.; Mishra, U.; Britton, B.; Giblin, J. T.; Mertz, J.; Scott, B. B.
10.1101/2025.03.21.644611 — neuroscience — Posted on 2025-03-22
1491 The Origin, Diagnosis, and Prognosis of Oligomannose-Type Diffuse Large B Cell Lymphoma
Tatterton, D. J.; Newby, M. L.; Allen, J. D.; Sale, B. J.; Chiodin, G.; Duriez, P. J.; Butler, J.; McCann, K. J.; Scott, D. W.; Morin, R. D.; Dreval, K.; Davies, A. J.; Bryant, D. J.; Crispin, M.; Forconi, F.
10.1101/2025.03.11.642396 — cancer biology — Posted on 2025-03-21
1495 Minus the Error: Testing for Positive Selection in the Presence of Residual Alignment Errors
Selberg, A.; Clark, N.; Sackton, T. B.; Muse, S.; Lucaci, A.; Weaver, S.; Nekrutenko, A.; Chikina, M.; Pond, S. L. K.
10.1101/2024.11.13.620707 — evolutionary biology — Posted on 2025-03-21
1498 Human Satellite 3 DNA encodes megabase-scale transcription factor binding platforms
Franklin, J. M.; Dubocanin, D.; Chittenden, C.; Barillas, A. G.; Lee, R. J.; Ghosh, R. P.; Gerton, J. L.; Guan, K.-L.; Altemose, N.
10.1101/2024.10.22.616524 — cell biology — Posted on 2025-03-21
1499 Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants
van Vlimmeren, A. E.; Tang, L. C.; Jiang, Z.; Iyer, A.; Voleti, R.; Krismer, K.; Gaublomme, J. T.; Jovanovic, M.; Shah, N. H.
10.1101/2025.02.26.640373 — molecular biology — Posted on 2025-03-21
1502 Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity
Buasakdi, C.; Stanton, C. R.; Bora, P.; Chatterjee, P.; Bollong, M. J.; Wiseman, L.
10.1101/2025.03.21.644355 — biochemistry — Posted on 2025-03-21
1503 Structural bases for Nuclear Factor 1-X activation and DNA recognition. Prototypic insight into the NFI transcription factor family
Tiberi, M.; Lapi, M.; Gourlay, L. J.; Chaves-Sanjuan, A.; Polentarutti, M.; Demitri, N.; Cavinato, M.; Bonnet, D. M. V. J.; Taglietti, V.; Righetti, A.; Sala, R.; Cauteruccio, S.; Kumawat, A.; Russo, R.; Barbiroli, A. G.; Gnesutta, N.; Camilloni, C.; Bolognesi, M.; Messina, G.; Nardini, M.
10.1101/2025.03.21.644642 — biochemistry — Posted on 2025-03-21
1505 Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA
Mahajan, S.; Pall, A. E.; Li, Y. E.; Stemmler, T. L.; Rees, D. C.; Clemons, W. M.
10.1101/2025.03.21.644500 — biochemistry — Posted on 2025-03-21
1506 Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex
Zhang, L.; Batters, C.; Aibara, S.; Gordiyenko, Y.; Zumer, K.; Maier, K.; Cramer, P.; Zhang, S.
10.1101/2025.03.21.644610 — molecular biology — Posted on 2025-03-21
1509 Clostridioides difficile Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic Epithelium
Thomas, S. A.; Pike, C. M.; Perkins, C. E.; Brown, S. T.; Espinoza Jaen, X. M.; McMillan, A. S.; Theriot, C. M.
10.1101/2025.03.21.644594 — microbiology — Posted on 2025-03-21
1510 Experimental metal contamination reduces gut microbiota diversity and alters its composition and function in wild-caught fish
PETITJEAN, Q.; JEAN, S.; GRANADA, M.; MANZI, S.; VEYSSIERE, C.; PERRAULT, A.; COUSSEAU, M.; LAFFAILLE, P.; JACQUIN, L.; WHITE, J.
10.1101/2025.03.21.644596 — microbiology — Posted on 2025-03-21
1511 Impact of pH and temperature in dairy processing on the infectivity of H5N1 avian influenza viruses
Lenz-Ajuh, N.; Rau, L.; Butticaz, L.; Zimmer, B.; Beuret, V.; Loosli, F.; Ingenhoff, J.-E.; Wieland, B.; Zimmer, G.
10.1101/2025.03.21.644501 — microbiology — Posted on 2025-03-21
1512 Effect of diesel contamination on bacterial populations in a pristine soil during rhizoremediation
van Dillewijn, P.; Hurtado-Fernandez, I.; Garrido-Pelaez, P.; Molina, L.; Udaondo, Z.; Velando, F.; Segura, A.
10.1101/2025.03.21.644530 — microbiology — Posted on 2025-03-21
1515 The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide.
Mahawar, U.; Davis, D. L.; Kannan, M.; Suemitsu, J.; Oltorik, C. D.; Farooq, F.; Fulani, R.; Weintraub, C.; Allegood, J.; Wattenberg, B.
10.1101/2025.03.20.643044 — biochemistry — Posted on 2025-03-21
1516 The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state
Balistreri, A.; Kolli, D.; Jayaweera, S. W.; Lundahl, D.; Han, Y.; Kalcec, L.; Goetzler, E.; Alessio, R.; Ruotolo, B.; Olofsson, A.; Chapman, M. R.
10.1101/2025.03.21.644623 — biochemistry — Posted on 2025-03-21
1517 Benchmarking of Human ReadRemoval Strategies for Viral andMicrobial Metagenomics
Forbes, M.; Ng, D. Y. K.; Boggan, R. M.; Frick-Kretschmer, A.; Durham, J.; Lorenz, O.; Dave, B.; Lassalle, F.; Scott, C.; Wagner, J.; Lignes, A.; Noaves, F.; Jackson, D. K.; Howe, K.; Harrison, E.
10.1101/2025.03.21.644587 — genomics — Posted on 2025-03-21
1518 Structural basis for human chondroitin sulfate chain polymerization
Dutta, P.; Lorizolla Cordeiro, R.; Friedel-Arboleas, M.; Bourgeais, M.; Vallet, S. D.; Weber, M.; Molinas, M.; Boeri-Erba, E.; Wild, R.
10.1101/2025.03.21.644485 — molecular biology — Posted on 2025-03-21
1519 TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition
Verma, A.; Kumar, G.; Khandelwal, N.; Mayer, B. E.; Rathee, J.; Chander, Y.; Nokhwal, A.; Dhanda, S.; Kumar, R.; Kamboj, H.; Thachamvally, R.; Sharma, S.; Kumar, N.
10.1101/2025.03.20.644376 — microbiology — Posted on 2025-03-21
1521 You Only Look Once (YOLO) Based Machine Learning Algorithm for Real-Time Detection of Loop-Mediated Isothermal Amplification (LAMP) Diagnostics
Mezgebo, B. K.; Chaffee, R.; Castellanos, R.; Ashraf, S.; Burke-Gaffney, J.; Pitout, J.; Iorga, B. I.; MacDonald, E.; Pillai, D. R.
10.1101/2025.03.21.644632 — microbiology — Posted on 2025-03-21
1522 Grapevine holobiome metatranscriptomics provides a glimpse into the wood mycovirome
Debat, H. J.; Paolinelli, M.; Escoriaza, G.; Garcia Lampasona, S.; Gomez Talquenca, S.; Bejerman, N.
10.1101/2025.03.21.644598 — microbiology — Posted on 2025-03-21
1524 The Legionella pneumophila peptidoglycan recycling kinase, AmgK, is essential for survival and replication inside host alveolar macrophages
Sushanta Ratna, S.; Lina Pradhan, L.; Marina P. Vasconcelos, M. P.; Aastha Acharya, A.; Bella Carnahan, B.; Alex Wang, A.; Arit Ghosh, A.; Abigail Bolt, A.; Jacob Ellis, J.; Stephen N. Hyland, S. N. H. N.; Ashlyn S. Hillman, A. S. H. S.; Joseph M. Fox, J. M. F. M.; April Kloxin, A. K.; M. Ramona Neunuebel, M. R. N.; Grimes, C. L.
10.1101/2025.03.21.644609 — microbiology — Posted on 2025-03-21
1525 Cannibalism Shapes Biofilm Structure and Composition in Bacillus subtilis
Friebel, L.; Knepper, J.-P.; Becker, N. S.; Abbaszade, G.; Stueckrath, K.; Mueller, S.; Dreisewerd, K.; Mascher, T.
10.1101/2025.03.21.644447 — microbiology — Posted on 2025-03-21
1528 A Comprehensive Reference Catalog of Human Skin DNA Virome Reveals Novel Viral Diversity and Microenvironmental Influences
Li, Z.; Li, S.; Han, C.; Chen, Y.; Zhen, H.; Sun, Y.; Zhou, X.; Chen, Y.; Zheng, Y.; Han, L.; Krutmann, J.; Nie, C.; Wang, J.; Xia, J.
10.1101/2025.03.20.644480 — microbiology — Posted on 2025-03-21
1531 Immune Antibodies Recognizing the Stem Region of SARS-CoV-2 Spike Protein: Molecular Modelling and In Vitro Study of Synthetic Peptides Presentation to the Antibodies
Aliper, E. T.; Ryzhov, I. M.; Obukhova, P. S.; Tuzikov, A. B.; Galanina, O. E.; Ziganshina, M. M.; Sukhikh, G. T.; Krylov, N. A.; Henry, S. M.; Efremov, R. G.; Bovin, N. V.
10.1101/2025.03.20.644166 — immunology — Posted on 2025-03-21
1532 Noise-guided tuning of synthetic protein waves in living cells
Bolshakov, D. T.; Weix, E. W. Z.; Galateo, T. M.; Rajasekaran, R.; Coyle, S. M.
10.1101/2025.03.21.644572 — synthetic biology — Posted on 2025-03-21
1533 A universal polyphosphate kinase powers in vitro transcription
Matsumoto, R.; Watanabe, T.; Yamazaki, E.; Kagawa, A.; Longo, L. M.; Matsuura, T.
10.1101/2025.03.21.644484 — synthetic biology — Posted on 2025-03-21
1538 Vasopressin-Dependent β-Catenin Phosphorylation at Ser552 and Branching Structure of Mouse Collecting Duct System
Ou, S.-M.; Kikuchi, H.; Park, E.; Yang, C.-R.; Raghuram, V.; Khan, S.; Murillo-de-Ozores, A. R.; Chen, L.; Chou, C.-L.; Knepper, M.
10.1101/2025.03.13.643123 — physiology — Posted on 2025-03-21
1539 In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer
Decker, M.; Huang, B. J.; Ware, T.; Boone, C.; Tang, M.; Ybarra, J.; Ballapuram, A. C.; Taran, K. A.; Chen, P.-Y.; Amendariz, M.; Leung, C. J.; Harris, M.; Tjoa, K.; Hongo, H.; Abelson, S.; Rivera, J.; Ngo, N.; Herbst, D. M.; Suciu, R. M.; Guijas, C.; Sedighi, K.; Andalis, T.; Roche, E.; Xie, B.; Liu, Y.; Smith, C. C.; Stieglitz, E.; Niphakis, M. J.; Cravatt, B.; Shannon, K.
10.1101/2025.03.20.644389 — cancer biology — Posted on 2025-03-21
1540 Combined genomic and molecular analysis defines prognostic markers of relapse in stage IA-IC1 clear cell ovarian carcinoma
Iida, Y.; Churchman, M.; Hollis, R. L.; Taylor, S.; Bartos, C.; Croy, I.; Gentleman, W.; Rye, T.; Nirsimloo, R.; Herrington, C. S.; Gourley, C.; Okamoto, A.; Thomson, J. P.
10.1101/2025.03.20.644313 — cancer biology — Posted on 2025-03-21
1541 Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers in metazoans
Liu, T.; Cao, L.; Mladenov, M.; Romet-Lemonne, G.; Way, M.; Moores, C.
10.1101/2025.01.31.635869 — biophysics — Posted on 2025-03-21
1543 Single neuron contributions to the auditory brainstem EEG
Kuokkanen, P. T.; Kraemer, I.; Koeppl, C.; Carr, C. E.; Kempter, R.
10.1101/2024.05.29.596509 — neuroscience — Posted on 2025-03-21
1544 Flexibility and Neural Correlates of Action-Sound Predictions
Aurich, F.; Widmann, A.; Dercksen, T.; Korka, B.; Richter, A.; Stenner, M.-P.; Wetzel, N.
10.1101/2025.03.19.644065 — neuroscience — Posted on 2025-03-21
1545 Time-resolved neural and experience dynamics of medium- and high-dose DMT
Lewis-Healey, E.; Pallavicini, C.; Cavanna, F.; D'Amelio, T.; De La Fuente, L. A.; Copa, D.; Muller, S.; Bruno, N.; Tagliazucchi, E.; Bekinschtein, T.
10.1101/2024.12.19.629418 — neuroscience — Posted on 2025-03-21
1547 Mapping Dynamic Metabolic Energy Distribution in Brain Networks using fMRI: A Novel Dynamic Time Warping Framework
Wiafe, S.-L.; Kinsey, S.; Soleimani, N.; Nsafoa, R.; Khasayeva, N.; Harikumar, A.; Miller, R.; Calhoun, V.
10.1101/2025.03.20.644399 — neuroscience — Posted on 2025-03-21
1549 RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors
Baars, B.; Orive-Ramos, A.; Kou, Z.; Gaire, B.; Desaunay, M.; Adamopoulos, C.; Aaronson, S. A.; Wang, S.; Gavathiotis, E.; Poulikakos, P. I.
10.1101/2025.02.14.638317 — cancer biology — Posted on 2025-03-21
1551 Inhibition of Renin Release, a Crucial Event in Homeostasis, is Mediated by Coordinated Calcium Oscillations within Juxtaglomerular Cell Clusters.
Yamaguchi, H.; Guagliardo, N. A.; Bell, L. A.; Yamaguchi, M.; Matsuoka, D.; Xu, F.; Smith, J. P.; Diagne, M.; Almeida, L. F.; Medrano, S.; Barrett, P. Q.; Nieh, E. H.; Gomez, A. R.; Sequeira-Lopez, M. L. S.
10.1101/2024.12.23.629519 — cell biology — Posted on 2025-03-21
1554 Motion processing in visual cortex of maculopathy patients
Michaud, C.; Guenot, J.; Faurite, C.; Gallice, M.; Chiquet, C.; Vayssiere, N.; Berry, I.; Trotter, Y.; Soler, V.; Peyrin, C.; Cottereau, B. R.
10.1101/2025.02.07.636620 — neuroscience — Posted on 2025-03-21
1555 Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease
Trushin, S.; Nguyen, O.; Stojakovic, A.; Ostroot, M.; Deason, T.; Chang, S.-y.; Zhang, L.; Macura, S.; Nambara., T.; Kanekiyo, T.; Lu, W.; Trushina, E.
10.1101/2025.02.12.637918 — neuroscience — Posted on 2025-03-21
1557 Virus-inclusive single-nucleus RNA sequencing reveals two distinct endothelial response patterns in infectious salmon anaemia.
Andresen, A. M. S.; Taylor, R. S.; Furniss, J.; Saghafian, M.; Kuiper, R. V.; Macqueen, D. J.; Fosse, J. H.
10.1101/2025.03.20.644265 — immunology — Posted on 2025-03-21
1560 A human-specific microRNA controls the timing of excitatory synaptogenesis
Soutschek, M.; LoBianco, A.; Galkin, S.; Wuest, T.; Colameo, D.; Germade, T.; Gross, F.; von Ziegler, L.; Bohacek, J.; Germain, P.-L.; Winterer, J.; Kleele, T.; Schratt, G.
10.1101/2023.10.04.560889 — neuroscience — Posted on 2025-03-21
1562 Pathway activation model for personalized prediction of drug synergy
Trac, Q. T.; Huang, Y.; Erkers, T.; Östling, P.; Bohlin, A.; Osterroos, A.; Vesterlund, M.; Jafari, R.; Siavelis, I.; Backvall, H.; Kiviluoto, S.; Orre, L.; Rantalainen, M.; Lehtiö, J.; Lehmann, S.; Kallioniemi, O.; Pawitan, Y.; Vu, T. N.
10.1101/2024.06.05.597583 — bioinformatics — Posted on 2025-03-21
1564 Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis
Ho, C. T.; Evans, E. B.; Lukasik, K.; O'Shaughnessy, E. C.; Shah, A.; Hsu, C.-H.; Temple, B.; Bear, J. E.; Gupton, S. L.
10.1101/2025.03.20.644333 — cell biology — Posted on 2025-03-21
1565 Crucial role for iron metabolism in mediating influenza A virus infection and associated disease
Pillar, A. L.; Daly, K.; Gomez, H. M.; Essilfie, A.-T.; Tan, K. S.; Liu, J.; Andiappan, A. K.; Brown, A. C.; Kim, R. Y.; Nichol, K.; Donovan, C.; Anderson, G. J.; Suhrbier, A.; Frazer, D.; Milward, E. A.; Chow, V. T.; Prabakaran, M.; Wang, D. Y.; Reid, D. W.; Hsu, A. C. Y.; Wark, P. A. B.; Horvat, J. C.; Mayall, J. R.
10.1101/2025.03.20.644262 — immunology — Posted on 2025-03-21
1566 LILRA5 functions to induce ROS production on innate immune cells
Fu, Z.; Rumpret, M.; Kube-Golovin, I.; Lyndin, M.; Solntceva, V.; Zhao, Y.; Konieva, A.; Liu, N.; Press, A.; Flohe, S.; Bauer, M.; Wennemuth, G.; Singer, B. B.; McCarthy, A. J.
10.1101/2025.03.16.643524 — immunology — Posted on 2025-03-21
1570 Gyral crowns contribute to the cortical infrastructure of human face processing
Willbrand, E. H.; Kelly, J. P.; Chen, X.; Zhen, Z.; Jiahui, G.; Duchaine, B.; Weiner, K. S.
10.1101/2025.03.20.644439 — neuroscience — Posted on 2025-03-21
1572 Optic Ataxia in Patients with Thalamic Lesions
Wilke, M.; Eisenberg, H.; Schmidt-Samoa, C.; Mahdavi, S.; Kagan, I.; Dechent, P.; Liman, J.; Karnath, H.-O.; Baehr, M.
10.1101/2025.03.20.644311 — neuroscience — Posted on 2025-03-21
1576 A class of secreted retropepsin-like enzymes is required for osmotic stress tolerance, antibiotic resistance and biofilm formation in Pseudomonas aeruginosa
Lormand, J. D.; Savelle, C. H.; Teschler, J. K.; Lopez, E.; Little, R. H.; Malone, J.; Yildiz, F. H.; Garcia-Garcia, M. J.; Sondermann, H.
10.1101/2025.03.18.643919 — microbiology — Posted on 2025-03-21
1578 Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations
Mei, I.; Nichterwitz, S.; Leboeuf, M.; Nijssen, J.; Lenoel, I.; Repsilber, D.; Lobsiger, C. S.; Hedlund, E.
10.1101/2024.03.15.584775 — neuroscience — Posted on 2025-03-21
1579 Loss of control of epithelial basal extrusion leads to tumor resistance in Drosophila
DE JOUSSINEAU, C.; VIALAT, M.; Baabdaty, E.; VACHIAS, C.; DEGOUL, F.; TROUSSON, A.; Pouchin, P.; LOBACCARO, J. M.; BARON, S.; MOREL, L.
10.1101/2025.03.18.643888 — cancer biology — Posted on 2025-03-21
1580 Critical Cell Spacing Drives Phase Transition in Matrix-Mediated Tissue Condensation
Peng, X.; Huang, Y.; Kong, W.; Du, Y.; Elson, E. L.; Feng, X.-Q.; Genin, G. M.
10.1101/2024.11.05.622090 — biophysics — Posted on 2025-03-21
1581 Nerpa 2: linking biosynthetic gene clusters to nonribosomal peptide structures
Olkhovskii, I.; Kushnareva, A.; Popov, P.; Tagirdzhanov, A.; Gurevich, A.
10.1101/2024.11.19.624380 — bioinformatics — Posted on 2025-03-21
1582 Investigating Alzheimers Disease Biomarkers by Applying Machine Learning Models
Khorsand, B.; Salehi, S.; Karimi, S.; Karimipasand, S.; Fariborzi, N.; Houri, H.; Asri, N.
10.1101/2025.03.19.643368 — bioinformatics — Posted on 2025-03-21
1583 Automatic Culture-free Detection of Bacteria from Blood for Rapid Sepsis Diagnostics
Miguelez, M. H. M.; Osaid, M.; Hallstrom, E.; Kaya, K.; Larsson, J.; Kandavalli, V.; Wahlby, C.; Elf, J.; van der Wijngaart, W.
10.1101/2024.05.23.595289 — bioengineering — Posted on 2025-03-21
1584 Patterns of sleeping site use of Guinea baboon parties (Papio papio)
Ohrndorf, L.; Mundry, R.; Beckmann, J.; Fischer, J.; Zinner, D.
10.1101/2025.03.20.644409 — ecology — Posted on 2025-03-21
1585 INFLUENCE OF PREMENSTRUAL SYNDROME ON ATTENTIONAL CAPTURE BY EXPRESSIONS IN THE LUTEAL PHASE
Alvarez, F.; Estrella, V.-Z.; Fernandez-Folgueiras, U.; Pita, M.; Kessel, D.; Carretie, L.
10.1101/2025.03.20.644193 — neuroscience — Posted on 2025-03-21
1586 Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay
Olsen, A.-K.; Ma, X.; Zheng, C.; Dahl, H.; Dirven, Y.; Boisen, A. M.; Sharma, A.; Eide, D. M.; Brunborg, G.
10.1101/2024.12.22.624648 — pharmacology and toxicology — Posted on 2025-03-21
1587 Photolipid-mediated Kv Channel Gating
Yadav, R.; Pfeffermann, J.; Goessweiner-Mohr, N.; Glasnov, T.; Akimov, S. A.; Pohl, P.
10.1101/2025.02.04.636384 — biophysics — Posted on 2025-03-21
1588 Modelling Eurasian lynx populations in Western Europe: What prospects for the next 50 years?
Bauduin, S.; Germain, E.; Zimmermann, F.; Idelberger, S.; Herdtfelder, M.; Heurich, M.; Kramer-Schadt, S.; Duchamp, C.; Drouet-Hoguet, N.; Morand, A.; Blanc, L.; Charbonnel, A.; Gimenez, O.
10.1101/2021.10.22.465393 — ecology — Posted on 2025-03-21
1590 Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics
Wang, J.; Montaser, A.; Sivonen, M.; Leinonen, H.; Hepojoki, J.; Ma, L.; Lehto, V.-p.; Xu, W.
10.1101/2025.02.27.640536 — immunology — Posted on 2025-03-21
1595 A Prelude to Conservation Genomics: First Chromosome-Level Genome Assembly of a Flying Squirrel (Pteromyini: Pteromys volans)
Wehrenberg, G.; Kiebler, A.; Greve, C.; Beltran-Sanz, N.; Ben Hamadou, A.; Meissner, R.; Winter, S.; Prost, S.
10.1101/2025.03.20.644356 — genomics — Posted on 2025-03-21
1597 Multi-omic human neural organoid cell atlas of the posterior brain
Azbukina, N.; He, Z.; Lin, H.-C.; Santel, M.; Kashanian, B.; Maynard, A.; Torok, T.; Okamoto, R.; Nikolova, M.; Kanton, S.; Broesamle, V.; Holtackers, R.; Camp, G.; Treutlein, B.
10.1101/2025.03.20.644368 — developmental biology — Posted on 2025-03-20
1599 SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells
Zhu, W.; Pan, L.; Cui, X.; Russo, A. C.; Ray, R.; Pederson, B.; Wei, X.; Lin, L. L.; Hafner, H.; Gregg, B.; Shrestha, N.; Liu, C.; Naji, A.; Arvan, P.; Sandoval, D.; Lindberg, I.; Qi, L.; Reinert, R. B.
10.1101/2025.03.20.644437 — cell biology — Posted on 2025-03-20
1600 Human airway organoids as a versatile model to study BSL-4 virus replication and pathogenesis
Wälzlein, J.-H.; Reusch, S.; Ospina-Garcia, J.; Olmer, R.; Schneider, M.; Klotz, C.; Kummer, S.
10.1101/2025.03.20.644281 — cell biology — Posted on 2025-03-20
1605 Rapid fluctuations in histamine associated with intake of nutritive and non-nutritive solutions
Volcko, K. L.; Gresch, A.; Benowitz, B.; Taghipourbibalan, H.; Visser, M.; Stuber, G. D.; Gordon-Fennell, A. G.; Patriarchi, T. E.; McCutcheon, J. E.
10.1101/2024.11.07.622425 — neuroscience — Posted on 2025-03-20
1606 Social stress, cortisol awakening response and sex: Impact on hippocampus and amygdala volume
Wang, R.; Noack, H.; Kuhn, L.; Nieratschker, V.; Habel, U.; Derntl, B.; Kogler, L.
10.1101/2025.03.20.644300 — neuroscience — Posted on 2025-03-20
1608 Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction.
Rahmat, M. B.; Hussain, A.; Teh, Y. X.; Dutta, B.; Pundrik, S.; Kappei, D.; Ito, Y.
10.1101/2024.12.10.626710 — cancer biology — Posted on 2025-03-20
1611 Far-Ultraviolet Light Causes Direct DNA Damage in Human Lung Cells and Tissues
Valanciute, A.; Ross, C. A.; Burden, A.; Mohanan, S. M. P. C.; Sabbah, M.; Ghobrial, J. M. W.; Dickson, S.; Loh, H. X.; Williams, E.; Ali, A.; Brahms, C.; Akram, A. R.; Paterson, L.; Jones, N. K.; Mills, B.; Travers, J. C.; Thomson, R. R.; Dhaliwal, K.
10.1101/2025.03.20.644314 — cell biology — Posted on 2025-03-20
1612 Red Blood Cell-derived Extracellular Vesicles enable Cisplatin and Cetuximab Synergistic Therapy against Triple-Negative Breast Cancer
Romano, M.; Musico, A.; Zendrini, A.; Gilberti, E.; Orlandi, F.; Pedrazzi, T.; Alacqua, S.; Segala, A.; Zenatelli, R.; Tassoni, S.; Paolini, L.; Cifola, I.; Mangano, E.; Consolandi, C.; Camboni, T.; Signati, L.; Mazzucchelli, S.; Neva, A.; Ragni, M.; Severgnini, M.; Valerio, A.; Pomarico, G.; Almici, C.; De Palma, G.; Corsi, F.; Bergese, P.; Radeghieri, A.
10.1101/2025.03.20.644320 — cell biology — Posted on 2025-03-20
1613 p62 sorts Lupus La and selected microRNAs into breast cancer-derived exosomes
Ngo, J. M.; Williams, J. K.; Temoche-Diaz, M. M.; Murugupandiyan, A.; Schekman, R.
10.1101/2025.03.20.644464 — cell biology — Posted on 2025-03-20
1614 Kinesin-3 KIF14 Regulates Intraflagellar Transport Dynamics in Primary Cilia
Mikulenkova, E.; Pejskova, P.; Podhajecky, R.; Stepanek, L.; Huranova, M.; Varga, V.; Lansky, Z.; Cajanek, L.
10.1101/2025.03.20.644298 — cell biology — Posted on 2025-03-20
1615 A Critical Role for Neutral Sphingomyelinase-2 in Doxorubicin-induced Cardiotoxicity
Mohammed, S.; Alvarado, V.; Jiang, Y.-P.; Velazquez, F. N.; Alexander, M. E.; Alvarez, F. A.; Chiappone, S. B.; Ostermeyer-Fay, A. G.; Zhang, L.; Shamseddine, A. A.; Canals, D.; Snider, A. J.; Lin, R. Z.; Hannun, Y. A.; Clarke, C. J.
10.1101/2025.03.20.644150 — cell biology — Posted on 2025-03-20
1617 Characterisation of the genomic sequence of an iflavirus, a protoambidensovirus, and of three microviruses detected in mosquitoes (Aedes albopictus and Culex quinquefasciatus)
Francois, S.; Antoine-Lorquin, A.; Mutuel, D.; Makoundou, P.; Perriat-Sanguinet, M.; Unal, S.; Sobry, H.; Gosselin-Grenet, A.-S.; Ogliastro, M.; Sicard, M.; Weill, M.; Atyame, C.; Boëte, C.
10.1101/2024.11.08.622592 — microbiology — Posted on 2025-03-20
1619 A Comprehensive Atlas of Cell Type Density Patterns and Their Role in Brain Organization
Munoz-Castaneda, R.; Palaniswamy, R.; Palmer, J.; Drewes, R.; Elowsky, C.; Hirokawa, K. E.; Cain, N.; Venkataraju, K. U.; Harris, J. A.; Wu, Z.; Osten, P.
10.1101/2024.10.02.615922 — neuroscience — Posted on 2025-03-20
1620 Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits
Hunker, A. C.; Wirthlin, M. E.; Gill, G.; Johansen, N. J.; Hooper, M.; Omstead, V.; Vargas, S.; Lerma, M. N.; Taskin, N.; Weed, N.; Laird, W. D.; Bishaw, Y. M.; Bendrick, J. L.; Gore, B. B.; Ben-Simon, Y.; Opitz-Araya, X.; Martinez, R. A.; Way, S. W.; Thyagarajan, B.; Otto, S.; Sanchez, R. E. A.; Alexander, J. R.; Amaya, A.; Amster, A.; Arbuckle, J.; Ayala, A.; Baker, P. M.; Barcelli, T.; Barta, S.; Bertagnolli, D.; Bielstein, C.; Bishwakarma, P.; Bowlus, J.; Boyer, G.; Brouner, K.; Casian, B.; Casper, T.; Chakka, A. B.; Chakrabarty, R.; Clark, M.; Colbert, K.; Daniel, S.; Dawe, T.; Departee,
10.1101/2024.09.27.615553 — neuroscience — Posted on 2025-03-20
1621 Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia
Yohida, T.; Sugino, H.; Yamamoto, H.; Tanno, S.; Tamura, M.; Igarashi, J.; Isomura, Y.; Hira, R.
10.1101/2024.07.12.603330 — neuroscience — Posted on 2025-03-20
1622 The developing Human Connectome Project fetal functional MRI release: Methods and data structures
Karolis, V. R.; Cordero-Grande, L.; Price, A.; Hughes, E.; Fitzgibbon, S. P.; Kyriakopoulou, V.; Uus, A.; Harper, N.; Prokopenko, D.; Bridglal, D.; Willers Moore, J.; Wilson, S.; Pietsch, M.; Christiaens, D.; Deprez, M.; Williams, L. Z. J.; Robinson, E. C.; Makropoulos, A.; Farahibozorg, S.-R.; O'Muircheartaigh, J.; Rutherford, M.; Rueckert, D.; Edwards, D.; Arichi, T.; Smith, S. M.; Duff, E.; Hajnal, J. V.
10.1101/2024.06.13.598863 — neuroscience — Posted on 2025-03-20
1623 It runs in the family: Discovery of enzymes in the oleuropein pathway in Olive (Olea europaea) by comparative transcriptomics
Calderini, O.; Kamileen, M. O.; Nakamura, Y.; Heinicke, S.; Alam, R. M.; Hong, B.; Jiang, Y.; Gutierrez, A.; Alagna, F.; Paolocci, F.; Valeri, M. C.; Franco, E.; Mousavi, S.; Mariotti, R.; Caputi, L.; O'Connor, S. E.; Rodriguez-Lopez, C. E.
10.1101/2025.03.20.644408 — biochemistry — Posted on 2025-03-20
1624 High Glucose Diet Induces Hepatic Iron Overload Contributing to Metabolic Dysfunction
Caceres, A.; Harder, N. H. O.; Padilla, J. P.; Janisse, S. E.; Cole, A. M.; Roedersheimer, S. E.; Heffern, M. C.
10.1101/2025.03.20.644441 — biochemistry — Posted on 2025-03-20
1625 A Prelude to Conservation Genomics: First Chromosome-Level Genome Assembly of a Flying Squirrel (Pteromyini: Pteromys volans)
Wehrenberg, G.; Kiebler, A.; Greve, C.; Beltran-Sanz, N.; Ben Hamadou, A.; Meissner, R.; Winter, S.; Prost, S.
10.1101/2025.03.20.644356 — genomics — Posted on 2025-03-20
1626 Novel insights into the genetic architecture and mechanisms of host/microbiome interactions from a multi-cohort analysis of outbred laboratory rats
Tonnele, H.; Chen, D.; Morillo, F.; Garcia-Calleja, J.; Chitre, A. S.; Johnson, B. B.; Sanches, T. M.; Bonder, M. J.; Gonzalez, A.; Kosciolek, T.; George, A. M.; Han, W.; Holl, K.; Horvath, A.; Ishiwari, K.; King, C. P.; Lamparelli, A. C.; Martin, C. D.; Martinez, A. G.; Netzley, A. H.; Tripi, J. A.; Wang, T.; Bosch, E.; Doris, P. A.; Stegle, O.; Chen, H.; Flagel, S. B.; Meyer, P. J.; Richards, J. B.; Robinson, T. E.; Woods, L. C. S.; Polesskaya, O.; Knight, R.; Palmer, A. A.; Baud, A.
10.1101/2025.03.20.644349 — genetics — Posted on 2025-03-20
1627 A duo of fungi and complex and dynamic bacterial community networks contribute to shape the Ascophyllum nodosum holobiont
Rousseau, C.; Tanguy, G.; Legeay, E.; Blanquart, S.; Arnaud, B.; Rousvoal, S.; Potin, P.; Leblanc, C.; Dittami, S. M.
10.1101/2025.03.20.643298 — ecology — Posted on 2025-03-20
1628 Enlarging viral mutation estimation: a view from the distribution of mutation rates
Furuyama, T. N.; de Carvalho Mello, I. M. V. G.; Janini, L. M. R.; Antoneli, F. M.
10.1101/2025.03.20.644362 — microbiology — Posted on 2025-03-20
1633 Biophysical characterization of Eag chaperones suggests the mechanism of effector transmembrane domain release
Van Schepdael, M.; Asakereh, I.; Colautti, J.; Gierys, A. J.; Ahmad, S.; Khajehpour, M.; Whitney, J. C.; Prehna, G.
10.1101/2025.03.20.644388 — biochemistry — Posted on 2025-03-20
1634 Artesunate Alleviate Kidney Fibrosis by Restoring Klotho Protein and Suppressing Wnt/β-Catenin Signalling Pathway
MOHAMMAD, G. H.; Kieswich, J.; Kumar, A.; McCafferty, K.; Chakraborty, R.; Thiemermann, C.; Yaqoob, M. M.
10.1101/2025.03.20.644310 — biochemistry — Posted on 2025-03-20
1635 A novel screening assay for insulin receptor
Stanurova, J.; Cermakova, K.; Zakova, L.; Sacha, P.; Jiracek, J.; Konvalinka, J.
10.1101/2025.03.20.644157 — biochemistry — Posted on 2025-03-20
1637 Sorted-Cell Proteomics Reveals an AT1-Associated Epithelial Cornification Phenotype and Suggests Endothelial Redox Imbalance in Human Bronchopulmonary Dysplasia
Ushakumary, M. G.; Chrisler, W. B.; Bandyopadhyay, G.; Huyck, H.; Gorman, B. L.; Beishembieva, N.; Pitonzo, A. K.; Lai, Z. J.; Fillmore, T. L.; Attah, I. K.; Dylag, A. M.; Misra, R. S.; Carson, J. P.; Adkins, J. N.; Pryhuber, G. S.; Clair, G.
10.1101/2025.03.20.644398 — biochemistry — Posted on 2025-03-20
1638 Naturally occurring variation in gene-associated transposable elements impacts gene expression and phenotypic diversity in woodland strawberry
Tossolini, I.; Tolley, R.; Llinares-Gomez, J.; Zlauvinen, C.; Toivainen, T.; Hytonen, T.; Pose-Padilla, D.; Martin-Pizarro, C.; Manavella, P.
10.1101/2025.03.20.644342 — genomics — Posted on 2025-03-20
1639 Immune recognition of transmissible cancers in Tasmanian devils with MHC-I deletion
Batley, K. C.; Pye, R. J.; Farquharson, K. A.; Cheng, Y.; Flies, A. S.; Hogg, C. J.; Belov, K.
10.1101/2025.03.20.644438 — genetics — Posted on 2025-03-20
1640 A systemically delivered AAV-CFTR gene therapy for cystic fibrosis
Plasschaert, L. W.; Stutz, C.; Otarola, E.; Ruggeri, L.; Misiolek, R. V.; Nuccio, A.; Shang, J.; Choo-Wing, R.; Taddase, B.; Decock, A.; Quigley, C.; Kubek-Luck, K.; Warnant, I.; Aibo, D. I.; Magnifico, M.; Buchs, M.; Tan, G.; Ashley, L.; Wang, H.-K.; Watson, R.; Lin, A.
10.1101/2025.03.20.642115 — genetics — Posted on 2025-03-20
1642 A new family of small ArdA proteins reveals an antirestriction activity.
Utkina, A. A.; Kudryavtseva, A. A.; Melkina, O. E.; Vlasov, A.; Rastorguev, S. M.; Manukhov, I. V.
10.1101/2025.03.20.644391 — molecular biology — Posted on 2025-03-20
1644 Influence of Copper Dose on Mycobacterium avium and Legionella pneumophila Growth in Premise Plumbing
Smeltz, R. E.; Roman, F. A.; Bryne, T.; Finkelstein, R.; Song, Y.; Pruden, A.; Edwards, M. A.
10.1101/2025.03.20.644365 — microbiology — Posted on 2025-03-20
1645 Extracellular redox sensors control the protein secretion stress response in Streptomyces
McLean, T. C.; Beaton, A. D. M.; Holmes, N. A.; Saalbach, G.; Martins, C.; Chandra, G.; Batey, S. F. D.; China, J.; Wilkinson, B.; Hutchings, M. I.
10.1101/2025.03.20.644377 — microbiology — Posted on 2025-03-20
1646 Community and functional stability in a working bioreactor degrading 1,4-dioxane at the Lowry Landfill Superfund Site
Romero, J. L.; Ratliff, J.; Carlson, C. J.; Griffiths, D. R.; Miller, C. S.; Mosier, A. C.; Roane, T. M.
10.1101/2025.03.20.644286 — microbiology — Posted on 2025-03-20
1647 Endophytic bacteria Bacillus velezensis NKG50 as a potential biocontrol agent of Ascochyta blight on chickpea
Valetti, L.; Sardo, F.; Fernandez, F. D.; Crociara, C. S.; Pastor, S.; Ruiz, O.; Monteoliva, M.
10.1101/2025.03.20.644328 — microbiology — Posted on 2025-03-20
1648 CD45-mediated apoptosis and IL2R downregulation by serine proteases from diarrheagenic bacteria
Liao, Y.; Ayala-Lujan, J. L.; Liu, L.; Gong, W.; Zhu, G.; Nataro, J.; Santiago, A. E.; Ruiz-Perez, F.
10.1101/2025.03.20.644266 — microbiology — Posted on 2025-03-20
1650 Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation
Zaman, M.; Yang, S.; Huang, Y.; Yarbro, J. M.; Hao, Y.; Wang, Z.; Liu, D.; Harper, K. E.; Soliman, H.; Hemphill, A.; Harvey, S.; Pruett-Miller, S. M.; Stewart, V.; Tanwar, A. S.; Kalathur, R.; grace, c. r.; Turk, M.; Chittori, S.; Jiao, Y.; Wu, Z.; High, A. A.; Wang, X.; Serrano, G. E.; Beach, T.; YU, G.; Yang, Y.; Chen, P.-C.; Peng, J.
10.1101/2025.03.20.644383 — biochemistry — Posted on 2025-03-20
1651 Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
Ketprasit, N.; Tai, C.-W.; Sharma, V. K.; Manickam, Y.; Khandokar, Y.; Ye, X.; Dogovski, C.; Hilko, D. H.; Morton, C.; Braun, A.-S. C.; Leeming, M.; Siddharam, B.; Shami, G. J.; Pradeepkumar, P. I.; Panjikar, S.; Poulsen, S.-A.; Griffin, M. D. W.; Sharma, A.; Tilley, L.; Xie, S. C.
10.1101/2025.03.20.644283 — biochemistry — Posted on 2025-03-20
1652 Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation
Jin, C.; Lundstrom, J.; Cori, C. R.; Guu, S.-Y.; Bennett, A. R.; Dannborg, M.; Bengtsson-Palme, J.; Hevey, R.; Khoo, K.-H.; Bojar, D.
10.1101/2025.03.20.644374 — biochemistry — Posted on 2025-03-20
1657 Early-life gut microbiome and stress-axis perturbations dysregulate systemic, mucosal, and brain immunity
Arrieta, M. C.; Ortega, V. A.; Asbury, M. R.; Mackenzie, C.; Vicentini, F. A.; Hafeez, B.; Duan, H.; Mercer, E. M.; vanTilburg Bernardes, E.; Kalbfleisch, K.; Samara, J.; Pettersen, V. K.; Figeys, D.; Sharkey, K.
10.1101/2025.03.19.644259 — microbiology — Posted on 2025-03-20
1659 Forecast Padding Enhances Accuracy and Robustness of EEG-Phase-Synchronized TMS
Chang, Y.-C.; Chao, P.-H.; Kuan, Y.-M.; Huang, C.-J.; Chen, L.-F.; Mao, W.-C.; Su, T.-P.; Chen, S.-H.; Wei, C.-S.
10.1101/2025.03.19.643976 — bioengineering — Posted on 2025-03-20
1660 Hydrogen-Induced Calcium Influx via the TRPC4-TRPC4AP Axis
Zhao, P.; li, H.; Cai, Z.; Zhang, X.; Wen, X.; Liu, Z.; Jiang, S.; Dang, Z.; Jiang, X.; Wang, J.; Liu, M.; Xie, F.; Ma, X.
10.1101/2025.03.19.644243 — biochemistry — Posted on 2025-03-20
1661 Resilience and vulnerabilities of tumor cells under purine shortage stress
Yu, J.; Jin, C.; Su, C.; Moon, D.; Sun, M.; Zhang, H.; Jiang, X.; Zhang, F.; Tserentsoodol, N.; Bowie, M. L.; Pirozzi, C. J.; George, D. J.; Wild, R.; Gao, X.; Ashley, D. M.; He, Y.; Huang, J.
10.1101/2025.03.19.644180 — cancer biology — Posted on 2025-03-20
1662 Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors
Wang, Y.; Huang, C.; Cai, G.; Andreatta, M.; Kurum, A.; Zhao, Y.; Feng, B.; Gao, M.; Carmona, S. J.; Zhou, Z.; Sun, C.; Guo, Y.; Tang, L.
10.1101/2025.03.19.643961 — cancer biology — Posted on 2025-03-20
1663 Deciphering the Pathogenic Landscape of Amyloid Light-Chain Cardiomyopathy
Ma, Q.; Wang, Z.; Zhu, J.; Yang, D.; Liu, X.; Xu, J.; PAN, X.; Zhang, N.
10.1101/2025.03.19.644248 — bioinformatics — Posted on 2025-03-20
1664 Eliminating steam pops and improving lesion safety in atrial ablation with conductive hydrogels
Post, A. D.; Jaworski, L.; Bernard, D.; Bashe, D.; Goal, S.; Zhang, H. D.; Nkansah, A.; Cosgriff-Hernandez, E.; Razavi, M.
10.1101/2023.10.03.560762 — bioengineering — Posted on 2025-03-20
1665 GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer
KITO, Y.; Gonzalez-Robles, T. J.; Kaisari, S.; Pae, J.; Garcia, S. F.; Ortiz-Pacheco, J.; Ueberheide, B.; Lehmann, R.; Marzio, A.; Rona, G.; Pagano, M.
10.1101/2025.03.18.643855 — cell biology — Posted on 2025-03-20
1666 Uncovering functional deterioration in the rhizosphere microbiome associated with wheat dwarfing
Smith, M. E.; Kavamura, V. N.; Hughes, D.; Mendes, R.; Lund, G. A.; Clark, I.; Mauchline, T.
10.1101/2025.03.16.643510 — microbiology — Posted on 2025-03-20
1667 A class of secreted retropepsin-like enzymes is required for osmotic stress tolerance, antibiotic resistance and biofilm formation in Pseudomonas aeruginosa
Lormand, J. D.; Savelle, C. H.; Teschler, J. K.; Lopez, E.; Little, R. H.; Malone, J.; Yildiz, F. H.; Garcia-Garcia, M. J.; Sondermann, H.
10.1101/2025.03.18.643919 — microbiology — Posted on 2025-03-20
1668 Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden
Camacho, E.; Dong, Y.; Chrissian, C.; Cordero, R. J.; Saraiva, R. G.; Anglero-Rodriguez, Y.; Smith, D. F. Q.; Jacobs, E.; Hartshorn, I.; Patino-Medina, J. A.; DePasquale, M.; Dziedzic, A.; Jedlicka, A.; Smith, B.; Mlambo, G.; Tripathi, A.; Broderick, N. A.; Stark, R. E.; Dimopoulos, G.; Casadevall, A.
10.1101/2024.09.30.615839 — microbiology — Posted on 2025-03-20
1669 Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens.
Kain, D.; Abdelhady, W.; McElfresh, G.; Cansler, M.; Swarbrick, G.; Poa, K.; McNeice, C.; Boggy, G.; Rott, K.; Null, M.; Lewinsohn, D.; Rossjohn, J.; Bimber, B. N.; Lewinsohn, D.
10.1101/2025.03.17.643805 — immunology — Posted on 2025-03-20
1670 Ghosts of symbionts past: The hidden history of the dynamic association between filarial nematodes and their Wolbachia endosymbionts
Vancaester, E.; Oldrieve, G. R.; Reid, A.; Koutsovoulos, G. D.; Laetsch, D. R.; Makepeace, B. L.; Tanya, V.; Poppert, S.; Krücken, J.; Wolstenholme, A.; Blaxter, M. L.
10.1101/2025.03.17.643741 — genomics — Posted on 2025-03-20
1671 Deep learning reveals the complex genetic architecture of a highly polymorphic sexual trait
van der Bijl, W.; Shu, J.; Goberdhan, V. S.; Sherin, L.; Jia, C.; Cortazar-Chinarro, M.; Corral-Lopez, A.; Mank, J. E.
10.1101/2023.09.29.560175 — evolutionary biology — Posted on 2025-03-20
1672 Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus formation
Ankenbauer, K. E.; Yang, Y.; Chung, C.-Y.; Andrade, L. R.; Weiser Novak, S.; Jarvis, B.; Ali Hanel, W. H.; Liu, J.; Sarkisian, V.; Dani, N.; Krystofiak, E.; Hu, G.; Ebrahim, S.; Kachar, B.; Gong, Q.; Wahl, G.; Manor, U.; Lau, K.; DelGiorno, K. E.
10.1101/2025.03.18.644042 — cell biology — Posted on 2025-03-20
1674 The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies
Kenet, A. L.; Achar, S.; Dwivedi, A.; Buckley, J.; Pouzolles, M.; Qin, H.; Chien, C.; Taylor, N.; Altan-Bonnet, G. Y.
10.1101/2025.03.17.643712 — immunology — Posted on 2025-03-20
1676 Impaired Visuospatial Working Memory but Preserved Attentional Control in Bipolar Disorder
Barnes-Scheufler, C. V.; Roesler, L.; Schiweck, C.; Peters, B.; Matura, S.; Mayer, J. S.; Kittel-Schneider, S.; Schaum, M.; Reif, A.; Wibral, M.; Bittner, R. A.
10.1101/2024.01.04.574011 — neuroscience — Posted on 2025-03-20
1677 Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Biswas, K.; Moore, C.; Rogers, H.; Wani, K. A.; Higgins, D. P.; Walker, A. K.; Pukkila-Worley, R.; Mullen, G. P.; Rand, J. B.; Francis, M. M.
10.1101/2025.01.06.628021 — neuroscience — Posted on 2025-03-20
1678 Conformational dynamics in the membrane interactions of bispecific targeted degrader therapeutics
Inganäs, E.; Laven, H.; Caraballo, R.; Klingegard, F.; Eklund, M.; Andersson, L.; Hilgendorf, C.; Matsson, P.
10.1101/2025.03.18.643966 — pharmacology and toxicology — Posted on 2025-03-20
1679 MYC Serine 62 phosphorylation promotes its binding to DNA double strand breaks to facilitate repair and cell survival under genotoxic stress.
Cohn, G. M.; Daniel, C.; Eng, J.; Sun, X.-X.; Pelz, C.; Chin, K.; Smith, A.; Lopez, C. D.; Brody, J. R.; DAI, M.; Sears, R. C.
10.1101/2025.03.19.644227 — cancer biology — Posted on 2025-03-20
1684 Early and widespread engagement of the cerebellum during hippocampal epileptiform activity
Streng, M. L.; Kottke, B. W.; Wasserman, E. M.; Zecker, L.; Luong, L.; kodandaramaiah, S. B.; Ebner, T.; Krook-Magnuson, E.
10.1101/2024.05.14.593969 — neuroscience — Posted on 2025-03-20
1685 The NaV1.5 auxiliary subunit FGF13 modulates channels by regulating membrane cholesterol independent of channel binding
Gade, A.; Malvezzi, M.; Das, L. T.; Matsui, M.; Ma, C.-I. J.; Mazdisnian, K.; Marx, S. O.; Maxfield, F. R.; Pitt, G. S.
10.1101/2025.03.19.644183 — biophysics — Posted on 2025-03-20
1692 Diversity and functional specialization of oyster immune cells uncovered by integrative single cell level investigations
De La Forest Divonne, S.; Pouzadoux, J.; Romatif, O.; Montagnani, C.; Mitta, G.; Destoumieux-Garzon, D.; Gourbal, B.; Charriere, G. M.; Vignal, E.
10.1101/2024.07.19.604245 — immunology — Posted on 2025-03-20
1695 Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis
Zhou, C.; Cen Feng, J. Y. C.; Liu, S.; Ventre, K. S.; Axelrad, J. E.; Jang, K. K.; Cadwell, K.
10.1101/2025.03.19.644201 — cell biology — Posted on 2025-03-20
1696 Benchmarking overlapping community detection methods for applications in human connectomics
Bryant, A. G.; Jha, A.; Agarwal, S.; Cahill, P.; Lam, B.; Oldham, S. G.; Arnatkeviciute, A.; Fornito, A.; Fulcher, B. D.
10.1101/2025.03.19.643839 — neuroscience — Posted on 2025-03-20
1697 The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured Brain.
Kansakar, S. B.; Sterben, S. P.; Anamala, C. C.; Thielen, M. D.; Liaudanskaya, V.
10.1101/2025.03.19.644244 — neuroscience — Posted on 2025-03-20
1698 Two Axes of White Matter Development
Luo, A. C.; Meisler, S. L.; Sydnor, V. J.; Alexander-Bloch, A.; Bagautdinova, J.; Barch, D. M.; Bassett, D. S.; Davatzikos, C.; Franco, A. R.; Goldsmith, J.; Gur, R. E.; Gur, R. C.; Hu, F.; Jaskir, M.; Kiar, G.; Keller, A. S.; Larsen, B.; Mackey, A. P.; Milham, M. P.; Roalf, D. R.; Shafiei, G.; Shinohara, R. T.; Somerville, L. H.; Weinstein, S. M.; Yeatman, J. D.; Cieslak, M.; Rokem, A.; Satterthwaite, T. D.
10.1101/2025.03.19.644049 — neuroscience — Posted on 2025-03-20
1704 Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas
Li, H.; Pemov, A.; Allaway, R. J.; Muir, D. F.; Chang, L.-J.; Banerjee, J.; Scott, A. J.; Nagy, J. M.; Liu, J.; Carrio, M.; Mazuelas, H.; Yachnis, A.; Lee, S. Y.; Zhang, X.; Lyu, Y.; Stewart, D. R.; Hirbe, A.; Blakeley, J. O.; Serra, E.; Wallis, D.; Wallace, M. R.
10.1101/2025.03.19.643702 — genomics — Posted on 2025-03-20
1710 Oxytocin Receptor Expression and Activation in Parasympathetic Brainstem Cardiac Vagal Neurons
Wang, X.; Ribeiro, C.; Nilsson, A.; Escobar, J. B.; Alber, B. R.; Bethea, J. R.; Polotsky, V. Y.; Kay, M. W.; Schunke, K.; Mendelowitz, D.
10.1101/2025.03.19.644204 — neuroscience — Posted on 2025-03-20
1714 GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research
Ingle, O. K.; Melville, L.; Beechener, S.; Hardy, C.; Howell, A.; Hobbs, N. P.; Mahon, N.; Morgan, E. R.; Bartley, D.; Rose Vineer, H.
10.1101/2025.02.21.639461 — ecology — Posted on 2025-03-20
1716 Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes
Shambhavi, S.; Mondal, S.; Chakraborty, A.; Shukla, N.; Panda, B. K.; Kumar, S.; Kinatukara, P.; Pal, B.; Kamat, S. S.; Sankaranarayanan, R.
10.1101/2024.10.15.618531 — cell biology — Posted on 2025-03-20
1717 Structure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development
Rijal, P.; Wei, L.; Paesen, G. C.; Stuart, D. I.; Howarth, M. R.; Huang, K.-Y. A.; Bowden, T. A.; Townsend, A. R.
10.1101/2024.10.11.617814 — immunology — Posted on 2025-03-20
1718 RAG suppresses group 2 innate lymphoid cells
Ver Heul, A.; Mack, M.; Zamidar, L.; Tamari, M.; Yang, T.-L.; Trier, A.; Kim, D.-H.; Janzen-Meza, H.; Van Dyken, S.; Hsieh, C.-S.; Karo, J. M.; Sun, J.; Kim, B. S.
10.1101/2024.04.23.590767 — immunology — Posted on 2025-03-20
1719 Detection of idiosyncratic gaze fingerprint signatures in humans
Crockford, S. K.; Satta, E.; Severino, I.; Fiacchino, D.; Vitale, A.; Bertelsen, N.; Busuoli, E. M.; Mandelli, V.; Lombardo, M. V.
10.1101/2023.09.18.558217 — neuroscience — Posted on 2025-03-20
1722 fMRI signals of pattern separation in the neocortex and hippocampus to non-meaningful objects and their spatial location
Nemecz, Z.; Homolya, I.; Ilyes, A.; Mezö, G.; Kis, H.; Varga, V. A.; Werkle-Bergner, M.; Keresztes, A.
10.1101/2024.10.09.617494 — neuroscience — Posted on 2025-03-20
1723 Design of nanobody targeting SARS-CoV-2 spike glycoprotein using CDR-grafting assisted by molecular simulation and machine learning
Ferraz, M. V. F.; Adan, W. C. S.; Lima, T. E.; Santos, A. J. C.; de Paula, S. O.; Dhalia, R.; Wallau, G. L.; Wade, R. C.; Viana, I. F. T.; Lins, R. D.
10.1101/2024.09.30.615772 — biophysics — Posted on 2025-03-20
1725 CarpeDeam: A De Novo Metagenome Assembler for Heavily Damaged Ancient Datasets
Kraft, L.; Soeding, J.; Steinegger, M.; Jochheim, A.; Fernandez-Guerra, A.; Renaud, G.
10.1101/2024.08.09.607291 — genomics — Posted on 2025-03-20
1726 Ancient tree-topologies and gene-flow processes among human lineages in Africa
Breton, G.; Sjodin, P.; Zervakis, P. I.; Laurent, R.; Froment, A.; Sjostrand, A. E.; Hewlett, B. S.; Barreiro, L. B.; Perry, G. H.; Soodyall, H.; Heyer, E.; Schlebusch, C. M.; Jakobsson, M.; Verdu, P.
10.1101/2024.07.15.603519 — genetics — Posted on 2025-03-20
1727 Normative high-frequency oscillation phase-amplitude coupling and effective connectivity under sevoflurane
Firestone, E.; Uda, H.; Kuroda, N.; Sakakura, K.; Sonoda, M.; Ueda, R.; Kitazawa, Y.; Lee, M.-H.; Jeong, J.-W.; Luat, A. F.; Cools, M. J.; Sood, S.; ASANO, E.
10.1101/2025.03.18.644050 — neuroscience — Posted on 2025-03-20
1728 A study of different pre-treatment methods for cigarettes and their aroma differences
Feng, T.; Li, d.; Gu, Y.; Zhang, C.; Fei, T.; Ma, L.; Wu, R.; Tao, L.; Tian, Z.
10.1101/2025.03.17.643679 — biochemistry — Posted on 2025-03-20
1729 Unveiling novel signaling roles for human KDELR3 and KDELR1KDELRs Control AGR2 Biogenesis
Palazzo, F. C.; Amagai, Y.; Dalla Torre, M.; Han, X.; Tempio, T.; Feige, M. J.; Garcia-Manteiga, J. M.; Matsumoto, M.; Sallese, M.; Inaba, K.; Sitia, R.; Anelli, T.
10.1101/2025.03.17.643648 — cell biology — Posted on 2025-03-20
1731 Expression of Non-Visual Opsins in the Green Anole Lizard (Anolis carolinensis)
Trejo-Reveles, V.; Anderson, G. E.; Jonhston, A. R.; Meddle, S.; Johnson, M.
10.1101/2025.03.20.644269 — zoology — Posted on 2025-03-20
1734 Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia
Wang, K.; Saniei, S.; Poddar, N.; Autar, S.; Carcamo, S.; Sreenath, M.; Peplinski, J. H.; Ries, R. E.; Martinez, I. G.; Chao, C.; Mei, A. H.-C.; Rahman, N.; Mekerishvili, L.; Quijada-Alamo, M.; Freed, G.; Zhang, M.; Lachman, K.; Diaz, Z.; Gonzalez, M. M.; Zhang, J.; Pham, G.; Filipescu, D.; Berisa, M.; Balestra, T.; Reisz, J. A.; D'Alessandro, A.; Puleston, D. J.; Bernstein, E.; Chipuk, J. E.; Wunderlich, M.; Tasian, S. K.; Marcellino, B. K.; Glass, I. A.; BDRL, ; Sturgeon, C. M.; Landau, D. A.; Chen, Z.; Papapetrou, E. P.; Izzo, F.; Meshinchi, S.; Hasson, D.; Wagenblast, E.
10.1101/2025.03.19.643917 — cancer biology — Posted on 2025-03-20
1735 Engineered micropillars to unveil oligodendrocyte responses to physical cues
Carvalho, E. D.; Morais, M. R. G.; Ferreira, H. P.; Athanasopoulou, G.; Hubbe, H.; Rocha, R.; Mattarelli, M.; Custodio, B.; Assis, S.; Gu, S. D.; Dalang, K. A. Y. P.; Rosemore, S. L.; Losert, W.; Lazaro, M. G.; Caponi, S.; Guimaraes, S. C.; Mendes, E.; Pego, A. P.
10.1101/2025.03.16.643578 — bioengineering — Posted on 2025-03-20
1736 Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation
Takei, T.; Sasazawa, Y.; Noshiro, D.; Kitagawa, M.; Kataura, T.; Mogi, H. H.; Kawauchi, E.; Nakano, Y.; Tashiro, E.; Saitoh, T.; Nishiyama, S.; Ogawa, S.; Kakuta, S.; Kazuno, S.; Miura, Y.; Korolchuk, V. I.; Noda, N. N.; Saiki, S.; Imoto, M.; Hattori, N.
10.1101/2025.03.17.643602 — biochemistry — Posted on 2025-03-20
1737 SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling
Uphoff, K.; Hussmann, M.; Schulte-Ostermann, D.; Huisman, Y.; Mörgelin, M.; Metzen, F.; Bazan, F. J.; Koch, M.; Schulte-Merker, S.
10.1101/2025.03.17.643633 — developmental biology — Posted on 2025-03-20
1738 Universal consensus 3D segmentation of cells from 2D segmented stacks
Zhou, F. Y.; Marin, Z.; Yapp, C.; Zou, Q.; Nanes, B. A.; Daetwyler, S.; Jamieson, A.; Islam, M. T.; Jenkins, E.; Gihana, G. M.; Lin, J.; Borges, H. M.; Chang, B.-J.; Weems, A.; Morrison, S. J.; Sorger, P. K.; Fiolka, R. P.; Dean, K. M.; Danuser, G.
10.1101/2024.05.03.592249 — bioinformatics — Posted on 2025-03-20
1740 Screening for links between behaviour and acute hyperthermia and hypoxia resistance in rainbow trout using isogenic lines
Lagarde, H.; LALLIAS, D.; Phocas, F.; Goardon, L.; Bideau, M.; Guyvarc'h, F.; Labbe, L.; Dupont-Nivet, M.; Cousin, X.
10.1101/2023.10.19.563047 — animal behavior and cognition — Posted on 2025-03-20
1741 Integrating Single-Molecule Sequencing and Deep Learning to Predict Haplotype-Specific 3D Chromatin Organization in a Mendelian Condition
Dubocanin, D.; Kalygina, A.; Franklin, J. M.; Chittenden, C.; Vollger, M. R.; Neph, S.; Stergachis, A. B.; Altemose, N.
10.1101/2025.02.26.640261 — genomics — Posted on 2025-03-20
1743 Single-cell resolution functional networks during unconsciousness are segregated into spatially intermixed modules
Kiyooka, D.; Oomoto, I.; Kitazono, J.; Saito, Y.; Kobayashi, M.; Matsubara, C.; Kobayashi, K.; Murayama, M.; Oizumi, M.
10.1101/2023.09.14.557838 — neuroscience — Posted on 2025-03-20
1745 Quantifying state-dependent control properties of brain dynamics from perturbation responses
Shikauchi, Y.; Takemi, M.; Tomasevic, L.; Kitazono, J.; Siebner, H. R.; Oizumi, M.
10.1101/2025.02.18.638784 — neuroscience — Posted on 2025-03-20
1747 Structural Determinants of Signal Speed: A Multimodal Investigation of Face Processing in Autism Spectrum Disorder
Coleman, C. R.; Nance, M. G.; Jacokes, Z.; Druzgal, T. J.; Arutiunian, V.; Kresse, A.; Sullivan, C. A. W.; Santhosh, M.; Neuhaus, E.; Borland, H.; Bernier, R. A.; Bookheimer, S. Y.; Dapretto, M.; Jack, A.; Jeste, S.; McPartland, J. C.; Naples, A.; Geschwind, D.; Gupta, A. R.; Webb, S. J.; Pelphrey, K. A.; Van Horn, J. D.; Newman, B. T.; Puglia, M. H.; on behalf of the ACE GENDAAR Consortium,
10.1101/2025.03.19.644214 — neuroscience — Posted on 2025-03-19
1748 Emergence of specific binding and catalysis from a designed generalist binding protein
Chen, Y.; Bhattacharya, S.; Bergmann, L.; Correy, G. J.; Tan, S.; Hou, K.; Biel, J.; Lu, L.; Bakanas, I.; Polizzi, N. F.; Fraser, J. S.; DeGrado, W. F.
10.1101/2025.01.30.635804 — biophysics — Posted on 2025-03-19
1750 Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast
Tvishamayi, C.; Ali, F.; Chaturvedi, N.; Madhu-Kumar, N.; Rashida, Z.; Ray, A.; Herminghaus, S.; Thutupalli, S.
10.1101/2024.11.26.625389 — evolutionary biology — Posted on 2025-03-19
1753 14-3-3ϵ UFMylation promotes RIG-I-mediated signaling
Gutierrez, I. V.; Park, M.; Sar, L.; Rodriguez, R.; Snider, D. L.; Torres, G.; Scaglione, K. M.; Horner, S. M.
10.1101/2025.03.19.644084 — immunology — Posted on 2025-03-19
1757 Structural Connectivity Correlates of Response to Electroconvulsive Therapy in Treatment-Resistant Depression
Samman, M. E.; Fiorentini, L.; Fazzito, M. L.; Herlyn, D. L.; Tsuchiyagaito, A.; Castro, M. N.; Costanzo, E.; Camprodon, J. A.; Forcato, C.; Guinjoan, S. M.; Villarreal, M. F.
10.1101/2025.03.18.643974 — neuroscience — Posted on 2025-03-19
1758 Endothelial cell Nrf2 controls neuroinflammation following a systemic insult
Zou, H.; Huang, Z.; He, X.; Mameli, E.; Leah, T.; Caporali, A.; Dando, O.; Qiu, J.
10.1101/2024.10.21.619507 — neuroscience — Posted on 2025-03-19
1759 Feminization of the precarious at the UNAM: examining obstacles to gender equality
ciccia, l.; Espinosa Lugo, G.; Garcia Guzman, G.; Gasca-Pineda, J.; Velez, P.; Espinosa Asuar, L.
10.1101/2024.05.13.593992 — scientific communication and education — Posted on 2025-03-19
1760 mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
Stavrides, P.; Goulbourne, C. N.; Peddy, J.; Huo, C.; Rao, M.; Khetarpal, V.; Marchionini, D. M.; Nixon, R. A.; Yang, D.-S.
10.1101/2024.05.29.596471 — pathology — Posted on 2025-03-19
1761 A large European diversity panel reveals complex azole fungicide resistance gains of a major wheat pathogen
Puccetti, G.; Badet, T.; Fluckiger, D.; Edel, D.; Feurtey, A.; Delude, C.; Gluck-Thaler, E.; Torriani, S. F. F.; Scalliet, G.; Croll, D.
10.1101/2025.03.19.644200 — microbiology — Posted on 2025-03-19
1762 Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors
Wang, Y.; Huang, C.; Cai, G.; Andreatta, M.; Kurum, A.; Zhao, Y.; Feng, B.; Gao, M.; Carmona, S. J.; Zhou, Z.; Sun, C.; Guo, Y.; Tang, L.
10.1101/2025.03.19.643961 — cancer biology — Posted on 2025-03-19
1763 Measuring Longitudinal Genome-wide Clonal Evolution of Pediatric Acute Lymphoblastic Leukemia at Single-Cell Resolution
Pang, Y.; Prieto, T.; Gonzalez-Pena, V.; Aragon, A.; Xia, Y.; Kao, S.; Rajagopalan, S.; Zinno, J.; Quentin, J.; Laval, J.; Yuan, D.; Shawn, S.; Omans, N.; Klein, D.; MacKay, M.; De Vlaminck, I.; Easton, J.; Evans, W.; Landau, D. A.; Gawad, C.
10.1101/2025.03.19.644196 — cancer biology — Posted on 2025-03-19
1766 PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinsons disease
Chiang, C. Y.; Pratuseviciute, N.; Lin, Y.-E.; Adhikari, A.; Yeshaw, W. M.; Flitton, C.; Sherpa, P. L.; Tonelli, F.; Rektorova, I.; Lynch, T.; Siuda, J.; Rudzinska-Bar, M.; Pulyk, O.; Bauer, P.; Beetz, C.; Dickson, D. W.; Ross, O. A.; Wszolek, Z.; Klein, C.; Zimprich, A.; Alessi, D. R.; Sammler, E. M.; Pfeffer, S. R.
10.1101/2025.03.19.644182 — cell biology — Posted on 2025-03-19
1767 Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus
Song, W.; Fiala, J.; Skalidis, I.; Albanese, P.; Patinios, C.; Chaillet, M. L.; Kengen, S.; Scheltema, R. A.; Howes, S.; Heck, A. J. R.; Forster, F.
10.1101/2025.03.19.643997 — molecular biology — Posted on 2025-03-19
1770 Pre- and postsynaptic mechanisms of neuronal inhibition assessed through biochemically detailed modelling of GABAB receptor signalling
Mäki-Marttunen, T.; Kismul, J. F.; Pajo, K.; Schulz, J. M.; Manninen, T.; Einevoll, G. T.; Linne, M.-L.; Andreassen, O. A.; Kotaleski, J. H.
10.1101/2025.03.19.644198 — neuroscience — Posted on 2025-03-19
1773 Enhanced PIEZO1 Function Contributes to the Pathogenesis of Sickle Cell Disease
Romero, L. O.; Bade, M.; Elsherif, L.; Williams, J. D.; Kong, X.; Adebiyi, A.; Ataga, K. I.; Ma, S.; Cordero-Morales, J. F.; Vasquez, V.
10.1101/2025.03.19.643952 — physiology — Posted on 2025-03-19
1775 Resilience and vulnerabilities of tumor cells under purine shortage stress
Yu, J.; Jin, C.; Su, C.; Moon, D.; Sun, M.; Zhang, H.; Jiang, X.; Zhang, F.; Tserentsoodol, N.; Bowie, M. L.; Pirozzi, C. J.; George, D. J.; Wild, R.; Gao, X.; Ashley, D. M.; He, Y.; Huang, J.
10.1101/2025.03.19.644180 — cancer biology — Posted on 2025-03-19
1776 Internal phase separation in synthetic DNA condensates
Tanase, D. A.; Osmanovic, D.; Rubio-Sanchez, R. M.; Malouf, L.; Franco, E.; Di Michele, L.
10.1101/2025.03.19.644034 — biophysics — Posted on 2025-03-19
1781 Development of a Pharmacokinetic (PK) Mouse Serum GLP ELISA for an Anti-CD19-AntiCD3 Diabody
Johnson, T.; Ahnoud, A.; DiNello, B.; ralph, p.; Cripe, T. P.; Wang, P.-Y.; Weiss, T. L.
10.1101/2025.03.19.644217 — immunology — Posted on 2025-03-19
1782 Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.
Willis, M. L.; Seim, R.; Herring, L. E.; Mordant, A. L.; Webb, T. S.; Cairns, B. A.; Upchurch, G.; Sharma, A. K.; Efron, P. A.; Wallet, S. M.; Coleman, L. G.; Maile, R.
10.1101/2025.03.19.644202 — immunology — Posted on 2025-03-19
1783 Functional Connectivity Alterations in Spinocerebellar Ataxia Type 10: Insights from Gray Matter Atrophy
Padron-Rivera, G.; Ramirez-Garcia, G.; Chirino-Perez, A.; Romero-Molina, A. O.; Ochoa-Morales, A.; Garcia-Gomar, G.; Ramirez-Garcia, M. A.; Rodriguez-Mendoza, O.; Torres, D. L.; Schule, B.; Pasaye-Alcaraz, E. H.; Hernandez-Castillo, C. R.; Fernandez-Ruiz, J.
10.1101/2025.03.19.644149 — neuroscience — Posted on 2025-03-19
1787 Impaired mitochondrial ketone body oxidation in insulin resistant states
Zweck, E.; Piel, S.; Schmidt, J.; Scheiber, D.; Schoen, M.; Kahl, S.; Burkart, V.; Dewidar, B.; Remus, R.; Chadt, A.; Al-Hasani, H.; Aubin, H.; Boeken, U.; Lichtenberg, A.; Polzin, A.; Kelm, M.; Westenfeld, R.; Wagner, R.; Schrauwen, P.; Szendroedi, J.; Roden, M.; Granata, C.
10.1101/2024.06.27.600966 — cell biology — Posted on 2025-03-19
1789 Predicting Task Activation Maps from Resting-State Functional Connectivity using Deep Learning
Madsen, S. J.; Lee, Y.-E.; Uddin, L. Q.; Mumford, J. A.; Barch, D. M.; Fair, D. A.; Gotlib, I. H.; Poldrack, R. A.; Kuceyeski, A.; Saggar, M.
10.1101/2024.09.10.612309 — neuroscience — Posted on 2025-03-19
1795 Ancient gene clusters initiate monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion
Hwang, J.; Kirshner, J.; Deschenes, D. A. R.; Richardson, M. B.; Fleck, S. J.; Guo, J.; Perley, J. O.; Shahsavarani, M.; Garza-Garcia, J. J. O.; Seveck, A. D.; Doiron, S. S.; Mai, Z.; Silliphant, S. N.; Calhoun, L.; Gao, D.; Lian, J.; Deslongchamps, G.; Albert, V. A.; Qu, Y.
10.1101/2025.01.07.631695 — biochemistry — Posted on 2025-03-19
1796 A simplified hybrid capture approach retains high specificity and enables PCR-free workflow
Mah, A.; Qi, X.; Zhao, J.; Wiseman, K.; Edoli, L.; Metcalfe, K.; Donohoe, K.; Ojeda, M.; Billings, S.; Moreno, J.; McCowin, M.; Krajacich, B.; Green, K.; Adhikary, R.; Boddicker, A.; Chan, J.; Mains, P.; Lajoie, B.; Devitt, S.; Kruglyak, S.; Levy, S.; Previte, M.
10.1101/2025.03.18.644033 — genomics — Posted on 2025-03-19
1797 Disinfecting eukaryotic reference genomes to improve taxonomic inference from ancient environmental metagenomic data
Oskolkov, N.; Jin, C.; Lopez Clinton, S.; Guinet, B.; Wijnands, F.; Johnson, E.; Kutschera, V. E.; Kinsella, C. M.; Heintzman, P. D.; van der Valk, T.
10.1101/2025.03.19.644176 — genomics — Posted on 2025-03-19
1798 PanSpace: Fast and Scalable Indexing for Massive Bacterial Databases
Avila Cartes, J. E.; Ciccolella, S.; Denti, L.; Raghuram Dandinasivara, R.; Della Vedova, G.; Bonizzoni, P.; Schonhuth, A.
10.1101/2025.03.19.644115 — genomics — Posted on 2025-03-19
1800 A pangenomic approach reveals the sources of genetic variation fueling the rapid radiation of Capuchino Seedeaters
Recuerda, M.; Kraemer, S.; Rosoni, J. R. R.; Repenning, M.; Browne, M.; Cataudela, J. F.; Di Giacomo, A. S.; Kopuchian, C.; Campagna, L.
10.1101/2025.03.19.644153 — evolutionary biology — Posted on 2025-03-19
1802 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.
Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devasri, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J.; Skeath, J.; Lacin, H.
10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-03-19
1804 Spatial Transcriptomics Identifies Immune-Stromal Niches Associated with Cancer in Adult Dermatomyositis
Anufrieva, K. S.; Shahriari, N.; Gao, C.; Castillo, R. L.; Liu, J.; Prell, S. A.; Kazerounian, S.; Afshari, K.; Kazakova, A. N.; Theisen, E.; Bowman, T.; LaChance, A.; Hashemi, K.; Korsunsky, I.; Rashighi, M.; Vleugels, R. A.; Wei, K.
10.1101/2025.03.19.644147 — immunology — Posted on 2025-03-19
1805 ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity
Jenkins, B. J.; Jenkins, Y. R.; Ponce-Garcia, F. M.; Moscrop, C.; Perry, I. A.; Hitchings, M. D.; Uribe, A. H.; Bernuzzi, F.; Eastham, S.; Cronin, J. G.; Berisha, A.; Howell, A.; Davies, J.; Blagih, J.; Veale, D. J.; Davies, L. C.; Niphakis, M.; Finlay, D. K.; Sinclair, L. V.; Cravatt, B.; Hogan, A. E.; Nathan, J. A.; Fearon, U.; Sumpton, D.; Vande Voorde, J.; Dias do Vale, G.; McDonald, J. G.; Jones, G. W.; Pearson, J. A.; Vincent, E. E.; Jones, N.
10.1101/2025.03.19.643996 — immunology — Posted on 2025-03-19
1806 14-3-3ϵ UFMylation promotes RIG-I-mediated signaling
Horner, S. M.; Gutierrez, I. V.; Park, M.; Sar, L.; Rodriguez, R.; Snider, D. L.; Torres, G.; Scaglione, K. M.
10.1101/2025.03.19.644084 — immunology — Posted on 2025-03-19
1809 Meditation induces shifts in neural oscillations, braincomplexity and critical dynamics: Novel insights fromMEG
Pascarella, A.; Tholke, P.; Meunier, D.; O'Byrne, J.; Lajnef, T.; Raffone, A.; Guidotti, R.; Pizzella, V.; Marzetti, L.; Jerbi, K.
10.1101/2025.03.18.643795 — neuroscience — Posted on 2025-03-19
1811 Is Britain still Great for Pine Marten? A Habitat Suitability Assessment
Lewis, E.; Ball, L.; Swinnerton, K.; Gardner, R.; Armour-Chelu, N.; Fitzmaurice, A.
10.1101/2025.03.19.643030 — zoology — Posted on 2025-03-19
1813 Ant head shape evolved to compromise bite-induced mechanical demands
Klunk, C. L.; Casadei-Ferreira, A.; Argenta, M. A.; Pie, M. R.
10.1101/2025.03.19.643247 — zoology — Posted on 2025-03-19
1819 Learning millisecond protein dynamics from what is missing in NMR spectra
Wayment-Steele, H. K.; El Nesr, G.; Hettiarachchi, R.; Kariyawasam, H.; Ovchinnikov, S.; Kern, D.
10.1101/2025.03.19.642801 — biophysics — Posted on 2025-03-19
1820 The Na V1.5 auxiliary subunit FGF13 modulates channels by regulating membrane cholesterol independent of channel binding
Gade, A.; Malvezzi, M.; Das, L. T.; Matsui, M.; Ma, C.-I. J.; Mazdisnian, K.; Marx, S. O.; Maxfield, F. R.; Pitt, G. S.
10.1101/2025.03.19.644183 — biophysics — Posted on 2025-03-19
1821 Genome-wide transcriptomic response of whole blood to radiation
Salah, A.; Wollschlaeger, D.; Callari, M.; Schmidberger, H.; Marini, F.; Zahnreich, S.
10.1101/2025.03.19.644086 — biophysics — Posted on 2025-03-19
1823 Predicting the conformational flexibility of antibody and T-cell receptor CDRs
Spoendlin, F. C.; Fernandez-Quintero, M. L.; Raghavan, S. S. R.; Turner, H. L.; Gharpure, A.; Loeffler, J. R.; Wong, W. K.; Georges, G.; Bujotzek, A.; Ward, A. B.; Deane, C. M.
10.1101/2025.03.19.644119 — bioinformatics — Posted on 2025-03-19
1826 On interactive spatial visualisation of pathogenicity predictions
Xu, J.; Kovacs, A. S.; Portelli, S.; Malik, A. J.; Ascher, D. B.
10.1101/2025.03.19.644131 — bioinformatics — Posted on 2025-03-19
1827 Collagen-binding IL-12 expressing STEAP1 CAR-T cells reduce toxicity and eradicate mouse prostate cancer in combination with checkpoint inhibitors
Sasaki, K.; Bhatia, V.; Asano, Y.; Bakhtiari, J.; Kaur, P.; Wang, C.; Matsuo, T.; Nikolaidi, M.; Chiu, P.-C.; Dubois, O.; Chong, T.; Javier, G.; Priceman, S. J.; Chapuis, A. G.; Lee, J. K.; Ishihara, J.
10.1101/2025.03.19.644145 — bioengineering — Posted on 2025-03-19
1829 Host traits impact the outcome of metagenomic library preparation from dental calculus samples across diverse mammals
Moraitou, M.; Richards, J.; Bolyos, C.; Saliari, K.; Gilissen, E.; Timmons, Z.; Kitchener, A. C.; Pauwels, O. S. G.; Sabin, R.; Kokkini, P.; Portela Miguez, R.; Guschanski, K.
10.1101/2025.03.19.643754 — genomics — Posted on 2025-03-19
1833 Chromosome-level genomics and historical museum collections reveal new insights into the population structure and chromosome evolution of waterbuck
Kirkland, C.; Wang, X.; Canedo-Ribeiro, C.; Alvarez-Gonzalez, L.; Weisz, D.; Mena, A.; St Leger, J.; Dudchenko, O.; Aiden, E. L.; Ruiz-Herrera, A.; Heller, R.; King, T.; Farre, M.
10.1101/2025.03.19.644014 — evolutionary biology — Posted on 2025-03-19
1837 RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning
Yoon, J.-B.; Trinh, L. T.; Vu, A. V.; Shin, S.; Lee, C.; Park, S.-H.; Cho, E.-B.; Heo, Y.; Kim, H. J.; Kim, S.
10.1101/2025.03.19.644102 — cell biology — Posted on 2025-03-19
1839 Skin but not gut microbial communities in Antarctic fur seals vary with social density
Botsidou, P.; Schloter, M.; Maraci, O.; Gschwendtner, S.; Nagel, R.; Forcada, J.; Hoffman, J. I.
10.1101/2025.03.19.644101 — microbiology — Posted on 2025-03-19
1841 A tissue-scale strategy for sensing threats in barrier organs
Nguyen, D. H.; Tian, J.; Shanahan, S.-L.; Wang, C.; Jacks, T.; Wang, X.; Li, P.
10.1101/2025.03.19.644134 — immunology — Posted on 2025-03-19
1842 Tracing LYVE1+ peritoneal fluid macrophages unveils two paths to resident macrophage repopulation with differing reliance on monocytes
Gallerand, A.; Han, J. J.; Mintz, R. L.; Chen, J.; Lee, D. D.; Chan, M. M.; Harmon, M. T.; Lin, X.; Huckstep, C. G.; Du, S.; Liu, T.; Kipnis, J.; Lavine, K. J.; Schilling, J.; Morley, S. C.; Zinselmeyer, B. H.; Randolph, G. J.
10.1101/2025.03.19.644175 — immunology — Posted on 2025-03-19
1844 Beyond the Resection: Surgical White Matter Disruption alters Non-Resected Brain Anatomy
Pruckner, P.; Mito, R.; Vaughan, D.; Jackson, G.; Fischmeister, F.; Nenning, K.-H.; Berger, M.; Pataraia, E.; Baumgartner, C.; Dorfer, C.; Roessler, K.; Czech, T.; Kasprian, G.; Bonelli, S.; Smith, R. E.
10.1101/2025.03.19.643850 — neuroscience — Posted on 2025-03-19
1845 Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease
Cavallo, A.; Köhler, R. M.; Busch, J. L.; Habets, J. G. V.; Merk, T.; Zvarova, P.; Vanhoecke, J.; Binns, T. S.; Al-Fatly, B.; de Almeida Marcelino, A. L.; Darcy, N.; Schneider, G.-H.; Krause, P.; Horn, A.; Faust, K.; Herz, D. M.; Yttri, E.; Cagnan, H.; Kühn, A. A.; Neumann, W.-J.
10.1101/2025.03.19.642627 — neuroscience — Posted on 2025-03-19
1846 Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species
De Schutter, J. D.; Zhang, A.; Serneels, P.-J.; Moons, L.; Masin, L.; Bergmans, S.
10.1101/2025.03.19.644129 — neuroscience — Posted on 2025-03-19
1850 Hair cell population integrity necessary to preserve vestibular function
Schenberg, L.; Simon, F.; Palou, A.; Dijan, C.; Tagliabue, M.; Llorens, J.; Beraneck, M.
10.1101/2025.03.19.644154 — neuroscience — Posted on 2025-03-19
1857 Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors
Pardo-Fernandez, L.; Moore, M.; Deshmukh, R.; Powley, I.; Waldron, J.; Kruspig, B.; McGarry, L.; Wood, C. S.; Leslie, H.; Hughes, M.; Jeldes, E.; Munro, J.; Mitchell, L.; Officer-Jones, L. S.; Pennie, R. L.; Jamieson, N.; Sumpton, D.; Strathdee, D.; Murphy, D. J.; Le Quesne, J. J.; Bushell, M.; Norman, J. C.
10.1101/2025.03.19.644135 — cancer biology — Posted on 2025-03-19
1858 Opposite patterns of association of TWIST1 expression with patient survival in SHH and Group 4 medulloblastoma
Coelho, K. M. P. A.; Dalmolin, M.; Pedack, F. R.; Pickler, J. G.; Barbosa, C.; Recalde, J.; Blasius, R.; Silva, B. L.; Fernandes, M. A. C.; Fronza Junior, H.; Franca, P. H. C.; Roesler, R.
10.1101/2025.03.19.644169 — cancer biology — Posted on 2025-03-19
1861 Directed Chemical Evolution via Navigating Molecular Encoding Space
Wang, L.; Wu, Y.; Luo, H.; Liang, M.; Zhou, Y.; Chen, C.; Liu, C.; Zhang, J.; Zhang, Y.
10.1101/2025.03.18.643899 — bioinformatics — Posted on 2025-03-19
1863 Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy
Madan, S.; Chang, T.; Harris, A. R.; Liu, H.; Martinez, A.; Dhruba, S. R.; Wang, B.; Rajagopal, P. S.; Sinha, S.; Srinivasan, A.; Knott, S. R. V.; Sayed, S.; Makokha, F.; Day, C.-P.; Gierach, G. L.; Ambs, S.; Schaffer, A. A.; Ruppin, E.
10.1101/2025.03.19.644074 — bioinformatics — Posted on 2025-03-19
1866 Population-scale analysis of inheritance patterns across 858,635 individuals reveals recent historical migration patterns across the North Sea from the Middle Ages to the Industrial Revolution
Zhang, X.; Holm, P.; Scally, A.; Banasik, K.; Mortensen, L. H.; Fitzgerald, T. W.; Westergaard, D.; Chmura, P. J.; Ostrowski, S. R.; Sorensen, E.; Pedersen, O. B. V.; Schwinn, M.; Erikstrup, C.; Bruun, M. T.; Jensen, B. A.; Ullum, H.; Mikkelsen, C.; Hansen, T. F.; DBDS Genetic Consortium, ; Stefansson, K.; Brunak, S.; Birney, E.
10.1101/2025.03.19.643007 — genetics — Posted on 2025-03-19
1867 Genetic differences in plasticity across environmental scales determine fitness along an ecological gradient
Walter, G. M.; Emma, G.; Terranova, D.; Clark, J.; Cozzolino, S.; Hiscock, S.; Cristaudo, A.; Bridle, J.
10.1101/2025.03.19.644087 — evolutionary biology — Posted on 2025-03-19
1872 CTCF-RNA interactions orchestrate cell-specific chromatin loop organization
Lucero, K.; Han, S.; Huang, P.-Y.; Qiu, X.; Mazzoni, E. O.; Reinberg, D.
10.1101/2025.03.19.643339 — cell biology — Posted on 2025-03-19
1873 Turning blood to brain cells: a plasma mediated reprograming model
Arora, R.; Bhardwaj, A.; Panda, N. K.; Das, R.; Gupta, T.; Bakshi, J.; Virk, R.; Nayak, G.; Patro, S. K.; Bhadada, S.; Pal, A.; Pal, R.; Chhabra, S.; Chhabra, S.; Pal, M.; Rashid, S.; SHARMA, M.
10.1101/2025.03.19.643269 — cell biology — Posted on 2025-03-19
1874 Acute high-dose irradiation of human primary ovarian cells reveals a shift in transcriptomics profile and impairment in cell-cell adhesion
Deligiannis, S. P.; Li, T.; Moussaud-Lamodiere, E.; Vegvari, A.; Damdimopoulos, A.; Lavogina, D.; Papaikonomou, K.; Zubarev, R.; Acharya, G.; Velthut-Meikas, A.; Damdimopoulou, P.; Salumets, A.; Di Nisio, V.
10.1101/2025.03.19.644095 — cell biology — Posted on 2025-03-19
1875 A lipoprotein partner for the Escherichia coli outer membrane protein TolC
Horne, J.; Kaplan, E.; Jin, B. H.; Petsolari, E.; Gradon, J. M.; Ntsogo, Y.; Harris, A.; Hu, D.; Luisi, B. F.
10.1101/2025.03.19.644130 — molecular biology — Posted on 2025-03-19
1876 LINC01503-MP is a Mitochondrial Microprotein That Promotes Cell Proliferation and Oxidative Metabolism.
Dewani, N.; Ruiz-Orera, J.; Popp, O.; Liang, N.; Sugawara, M.; Schulz, J. F.; Witte, F.; Sandmann, C.; Tsuji, T.; Blachut, S.; Katagiri, T.; Kondova, I.; Owada, S.; Yoshii, S.; Kataoka, H.; Kurtz, A.; Nakase, H.; van Heesch, S.; Mertins, P.; Hübner, N.; Kanda, M.
10.1101/2025.03.19.644091 — molecular biology — Posted on 2025-03-19
1879 Neural Synchrony Links Sensorimotor Cortices in a Network for Facial Motor Control
Vazquez, Y.; Ianni, G. R.; Rassi, E.; Rouse, A. G.; Schieber, M. H.; Yazdani, F.; Prut, Y.; Freiwald, W. A.
10.1101/2025.03.04.641458 — neuroscience — Posted on 2025-03-19
1880 Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits.
Antoniazzi, A. M.; Unda, S. R.; Norman, S.; Pomeranz, L. E.; Marongiu, R.; Stanley, S. A.; Friedman, J. M.; Kaplitt, M. G.
10.1101/2025.03.18.644041 — neuroscience — Posted on 2025-03-19
1882 scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy
Al Ojaimi, Y.; Hergesheimer, R.; Chami, A.; Alarcan, H.; Augros, J.; Dangoumau, A.; Haouari, S.; Bourgeais, J.; Lefevre, A.; Osman, S.; Emond, P.; Vourc'h, P.; Andres, C.; Corcia, P.; Herault, O.; Martineau, P.; Lanznaster, D.; Blasco, H.
10.1101/2025.03.19.644089 — neuroscience — Posted on 2025-03-19
1883 A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of Fmr1 KO mice and caused by loss of FMRP in cortical excitatory neurons
Kornfeld-Sylla, S. S.; Gelegen, C.; Norris, J. E.; Chaloner, F. A.; Lee, M.; Khela, M.; Heinrich, M. J.; Finnie, P. S. B.; Ethridge, L.; Erickson, C. A.; Schmitt, L. M.; Cooke, S. F.; Wilkinson, C. L.; Bear, M. F.
10.1101/2025.03.19.644144 — neuroscience — Posted on 2025-03-19
1884 Expression of Tacr1 and Gpr83 by spinal projection neurons
Ma, W.; Dickie, A. C.; Polgar, E.; Yadav, M.; Quillet, R.; Gutierrez-Mecinas, M.; Bell, A. M.; Todd, A.
10.1101/2025.03.19.643956 — neuroscience — Posted on 2025-03-19
1887 An unbiased cell-culture selection yields DNA aptamers as novel senescent cell-specific reagents
Pearson, K. S.; Jachim, S. K.; Doherty, C. D.; Wilbanks, B. A.; Prieto, L. I.; Dugan, M.; Baker, D. J.; LeBrasseur, N. K.; Maher, L. J.
10.1101/2025.03.19.643361 — biochemistry — Posted on 2025-03-19
1889 High-resolution NMR spectroscopy of proteins in intact mitochondria
Zhang, Z.; Zhang, C.; Xu, G.; Du, R.; Yu, J.; Liu, X.; Chai, Z.; Wu, Q.; Jiang, L.; Liu, M.; Li, C.
10.1101/2025.03.19.644076 — biochemistry — Posted on 2025-03-19
1891 Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Bushman, J. W.; Deng, W.; Samarasinghe, K. T. G.; Liu, H.-Y.; Li, S.; Vaish, A.; Golkar, A.; Ou, S.-C.; Ahn, J.; Harijan, R. K.; Han, H.; Duffy, T.; Imler, E.; Wu, J.; Rawson, R.; Liu, L.; Ndungu, J. M.; Hocker, M. D.; Roy, A.; Senese, A. D.; Lin, C.-C.; Tran, D.; Campos, A.; Blanco, G.; Toth, J. I.; Velentza, A.; Burritt, A.; Parker, G. S.; Thompson, P. A.; Bailey, S.; den Besten, W.; Voss, S.; Zhou, B.; Ashton, K. S.; Bedel, O.; Min, J.; Potts, P. R.
10.1101/2025.03.19.644003 — biochemistry — Posted on 2025-03-19
1892 MyoRep: a novel reporter system to detect early muscle atrophy in vitro and in vivo
Re Cecconi, A. D.; Rizzi, N.; Barone, M.; Palo, F.; Lunardi, M.; Forti, M.; Maggi, A.; Ciana, P.; Terribile, G.; Chiappa, M.; Zentilin, L.; Piccirillo, R.
10.1101/2025.02.27.640021 — genetics — Posted on 2025-03-19
1894 Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation
Wang, S.; Baumert, R.; Sejourne, G.; Sivadasan Bindu, D.; Dimond, K.; Sakers, K.; Vazquez, L.; Moore, J. L.; Tan, C. X.; Takano, T.; Rodriguez Salazar, M. P.; Brose, N.; Bradley, L.; Lessing, R.; Soderling, S. H.; La Spada, A. R.; Eroglu, C.
10.1101/2023.04.09.536178 — neuroscience — Posted on 2025-03-19
1896 RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors
Baars, B.; Orive-Ramos, A.; Kou, Z.; Gaire, B.; Desaunay, M.; Adamopoulos, C.; Aaronson, S. A.; Wang, S.; Gavathiotis, E.; Poulikakos, P. I.
10.1101/2025.02.14.638317 — cancer biology — Posted on 2025-03-19
1897 Decoupling Phase Separation and Fibrillization Preserves Activity of Biomolecular Condensates
Mahendran, T. S.; Singh, A.; Srinivasan, S.; Jennings, C. M.; Neureuter, C.; Gindra, B. H.; Parekh, S. H.; Banerjee, P. R.
10.1101/2025.03.18.643977 — biophysics — Posted on 2025-03-19
1900 In-depth 3D Exploration of Autosomal Dominant Polycystic Kidney Disease Through Light Sheet Fluorescence Microscopy
Delgado-Rodriguez, P.; Vitoria, I.; Rios-Munoz, G. R.; Bardia, L.; Lamanna-Rama, N.; Nicolas-Saenz, L.; Sporring, J.; Soto-Montenegro, M. L.; Aldabe, R.; Colombelli, J.; Munoz-Barrutia, A.
10.1101/2025.03.18.644002 — bioengineering — Posted on 2025-03-19
1902 An extensive and unbiased genome-wide scan for parent-of-origin expressed genes in the pig clarifies the conservation landscape of genomic imprinting
Perret, M.; Iannuccelli, N.; Leroux, S.; Feve, K.; Dehais, P.; Jacomet, E.; Hubert, J.-N.; Iampietro, C.; Vandecasteele, C.; Maman, S.; Faraut, T.; Liaubet, L.; Bonnet, A.; Donnadieu, C.; Riquet, J.; Demars, J.
10.1101/2025.03.09.642261 — genomics — Posted on 2025-03-19
1903 Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast
Tvishamayi, C.; Ali, F.; Chaturvedi, N.; Madhu-Kumar, N.; Rashida, Z.; Ray, A.; Thutupalli, S.
10.1101/2024.11.26.625389 — evolutionary biology — Posted on 2025-03-19
1904 Advanced flowering phenology of restored grasslands
Willems, F. M.; Bantin, J.; Hoelzel, N.; Bucharova, A.
10.1101/2025.03.18.643883 — ecology — Posted on 2025-03-19
1906 A high-resolution subcellular map of proteins in ciliated cells
Bertilsson, F.; Hikmet, F.; Hansen, J. N.; Uhlen, M.; Mear, L.; Lindskog, C.
10.1101/2025.03.18.643967 — cell biology — Posted on 2025-03-19
1907 Efficient delivery of mRNA-LNPs in primary and secondary liver cancer
Leighton, L. J.; Gee, Y. J.; Madugalle, S. U.; Victorova, M.; Carrodus, N. L.; Bridle, K. R.; Howell, S. A.; Liang, X.; Miller, G. C.; McMillan, C. L. D.; Wijesundara, D. K.; Muller, D. A.; Crawford, D. H. G.; Mercer, T. R.; Cheetham, S. W.
10.1101/2025.03.18.643845 — molecular biology — Posted on 2025-03-19
1908 Efficient gastrointestinal colonization by Campylobacter jejuni requires components of the ChuABCD heme transport system
Randaisi, V. R.; Bunch, M. L.; Beavers, W. N.; Rogers, T.; Ashurst, T. D.; Donohoe, D.; Monteith, A. J.; Johnson, J.
10.1101/2025.03.18.643992 — microbiology — Posted on 2025-03-19
1909 Tracking Replicating HPV Genomes in Proliferating Keratinocytes
Shin, J. R.; Avilov, I.; Schelhaas, M.; Gallardo, F.; McBride, A. A.
10.1101/2025.03.18.644043 — microbiology — Posted on 2025-03-19
1911 Sialoglycans modulate Siglec-5 - TLR4 Interactions in Osteoarthritis
Raberg, L.; Jia, F.; von Mentzer, U.; Karlsson, N. G.; Stubelius, A.
10.1101/2025.03.18.643878 — immunology — Posted on 2025-03-19
1914 A tactile discrimination task to study neuronal dynamics in freely-moving mice
Heimburg, F.; Mari Saluti, N.; Timm, J.; Adlakha, A.; Bortolozzo-Gleich, M. H.; Martin-Cortecero, J.; Castelanelli, M.; Klumpp, M.; Embray, L.; Both, M.; Kuner, T.; Groh, A.
10.1101/2024.08.24.609326 — neuroscience — Posted on 2025-03-19
1919 Immiscible proteins compete for RNA binding to order condensate layers
Snead, W. T.; Skillicorn, M. K.; Shrinivas, K.; Gladfelter, A. S.
10.1101/2025.03.18.644007 — biophysics — Posted on 2025-03-19
1925 Autonomous learning of pathologists' cancer grading rules
Nguyen, T. H.; Panwar, V.; Jarmale, V.; Perny, A.; Dusek, C.; Cai, Q.; Kapur, P. H.; Danuser, G.; Rajaram, S.
10.1101/2025.03.18.643999 — bioinformatics — Posted on 2025-03-19
1926 LM-GlycoRepo Version 1.0: A novel repository system for mouse tissue glycome mapping data
Nagai-Okatani, C.; Fujita, N.; Boottanun, P.; Tanaka, M.; Shiota, M.; Shinmachi, D.; Angata, K.; Aoki-Kinoshita, K.; Kuno, A.
10.1101/2025.03.18.644044 — bioinformatics — Posted on 2025-03-19
1927 Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues
Ling, Z.; Niego, B.; Li, Q.; Villa, V. S.; Bhattaram, D.; Hu, M.; Gong, Z.; Smith, L. M.; Frey, B. L.; Ren, X.
10.1101/2025.03.18.643336 — bioengineering — Posted on 2025-03-19
1932 Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease PfROM8 and cation channel PfCSC1.
Boulet, C.; Modak, J. K.; Counihan, N. A.; Parkyn Schneider, M.; Nguyen, W.; Dans, M. G.; Barnes, C. B. G.; Razook, Z.; McCann, k.; Barry, A. E.; Crabb, B. S.; de Koning-Ward, T. F.; Gilson, P. R.
10.1101/2025.03.18.644039 — microbiology — Posted on 2025-03-19
1933 Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice
Maeda, Y.; Rabenow, M.; Xiang, W.; Schmid, E.; Amend, L.; Otterbein, N.; Sarfati, I.; Miyagawa, I.; Gimaev, I.; Ehnes, L.; Lesker, T. R.; Danzer, H.; Sarter, K.; Duerholz, K.; Schaelter, F.; Bao, L.; Wirtz, S.; Arnold, P.; Hofmann, J.; Sjoeberg, D.; Svaerd, A.; Kastbom, A.; Schett, G.; Strowig, T.; Zaiss, M. M.
10.1101/2025.03.18.643707 — immunology — Posted on 2025-03-19
1934 Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression
van der Heide, V.; McArdle, S.; Nelson, M. S.; Cerosaletti, K.; Gnjatic, S.; Mikulski, Z.; Posgai, A. L.; Kusmartseva, I.; Atkinson, M. A.; Homann, D.
10.1101/2025.03.18.644000 — immunology — Posted on 2025-03-19
1935 Lymphocyte alterations and elevated complement signalling are key distinguishing features of Refractory Myasthenia Gravis
Dodd, K. C.; Baillie, K.; Holt, J. K.; Leite, M. I.; Miller, J. A.; Spillane, J.; Viegas, S.; Zelek, W.; Sussman, J.; Menon, M.
10.1101/2025.03.15.643341 — immunology — Posted on 2025-03-19
1936 Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells
Alsubaiti, A.; Alamir, H.; Huynh, L.; Grant, T.; Aljohani, A.; Chou, P. H.; Shi, Y.; Alismail, M.; Mason, L. R.; Herman, A.; Bridgeman, J. S.; Holland, C. J.; Wuelfing, C.
10.1101/2025.03.18.643973 — immunology — Posted on 2025-03-19
1938 Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits.
Antoniazzi, A. M.; Unda, S. R.; Norman, S.; Pomeranz, L. E.; Marongiu, R.; Stanley, S. A.; Friedman, J. M.; Kaplitt, M. G.
10.1101/2025.03.18.644041 — neuroscience — Posted on 2025-03-19
1939 DNMT1-Mediated Regulation of Somatostatin-positive Interneuron Migration Impacts Cortical Architecture and Function
Reichard, J.; Wolff, P.; Xie, S.; Zuo, K.; Fullio, C. L.; Du, J.; Graff, S.; Linde, J.; Yildiz, C. B.; Pitschelatow, G.; Nabbefeld, G.; Dorp, L.; Vollmer, J.; Biemans, L.; Kempf, S.; Singh, M.; Mohan, N. K.; Kuo, C.-C.; Vogel, T.; Carloni, P.; Musall, S.; Zimmer-Bensch, G. M.
10.1101/2024.09.04.611268 — neuroscience — Posted on 2025-03-19
1940 Validation of Body Condition Scoring as a Screening Test for Low Body Condition and Obesity in Common Marmosets (Callithrix jacchus)
Arroyo, J. P.; Alvarez, A.; Alvarez, L.; Hickmott, A. J.; Mustoe, A.; Brasky, K.; Reveles, K. R.; Ridenhour, B. J.; Amato, K. R.; Power, M. L.; Ross, C. N.
10.1101/2025.03.18.643796 — physiology — Posted on 2025-03-19
1943 Antidepressants interact with an LPA3 receptor binding site: functional and docking studies
Solis, K. H.; Jardon-Ibanez, A. I.; Romero-Avila, M. T.; Rincon-Heredia, R.; Correa-Basurto, J.; GARCIA-SAINZ, J. A.
10.1101/2025.03.18.644008 — pharmacology and toxicology — Posted on 2025-03-19
1944 Predicting allergy and postpartum depression from incomplete compositional microbiome
Shternshis, A.; Tong, B.; Skalkidou, A.; Wahlby, C.; Zachariah, D.; Hugerth, L. W.; Singh, P.
10.1101/2025.02.28.640766 — bioinformatics — Posted on 2025-03-19
1952 Annual Cultivated Extent and Agricultural Land Use Expansion across the Central Grasslands of North America, 1996-2021
Carter, S.; Morford, S.; Tack, J.; Lark, T.; Uludere Aragon, N.; Allred, B.; Twidwell, D.; Naugle, D.
10.1101/2025.03.18.643874 — ecology — Posted on 2025-03-19
1954 IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer.
Doultsinos, D.; Tomljanovic, I.; Pilalis, E.; Abusamra, S.; Parmentier, R.; Bridges, I. E.; Figiel, S.; Zekri, Y.; Hester, J.; Leach, D.; Bevan, C. L.; Lamb, A. D.; Zwart, W.; Chatziioannou, A.; Le Magnen, C.; Mills, I. G.
10.1101/2025.03.13.643042 — cancer biology — Posted on 2025-03-19
1955 A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis
Petrovic, I.; Desai, S.; Isaikina, P.; Abiko, L. A.; Spang, A.; Grzesiek, S.
10.1101/2024.11.04.621860 — biochemistry — Posted on 2025-03-19
1959 Flexibility and Neural Correlates of Action-Sound Predictions
Aurich, F.; Widmann, A.; Dercksen, T.; Korka, B.; Richter, A.; Stenner, M.-P.; Wetzel, N.
10.1101/2025.03.19.644065 — neuroscience — Posted on 2025-03-19
1962 Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities
van den Broek, T. J. M.; Hoogendijk, R.; Kranendonk, M. E. G.; Lammers, J. A. S.; Krishnamoorthy, A. L.; van Ineveld, R. L.; Molleson, M.; Tsvetkov, V. O.; Ringnalda, F. A. C.; van de Wetering, M.; Su, Y.; Bianco, J. I.; Ruiz Moreno, C.; Ries, M. G.; Hoving, E. W.; van der Lugt, J.; Akkari, L.; Schrijver, D. P.; Stunnenberg, H. G.; Rios, A. C.; van Vuurden, D. G.; Zomer, A.
10.1101/2025.03.18.643953 — cancer biology — Posted on 2025-03-19
1967 A nonsense mutation in the PRKG2 gene in Dalmatian dogs with chondrodysplasia
Mäkeläinen, S.; Ekman, S.; Hytönen, M. K.; Lohi, H.; Kyöstilä, K.; Simon, T.; Andersson, G.; Hedhammar, A.; Hansson, K.; Bergstrom, T. F.
10.1101/2025.03.18.644031 — genetics — Posted on 2025-03-19
1968 From bones to sediments: ancient human DNA from open-air archaeological sites
Sawafuji, R.; Sawaura, R.; Yokoo, M.; Kumaki, T.; Thomasen, N. A.; Tsutaya, T.; Pedersen, M. W.
10.1101/2025.03.19.643861 — molecular biology — Posted on 2025-03-19
1969 A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain.
Villa-Hernandez, S.; Walker, J. V.; Hore, Z.; Fedele, L.; Zebochin, I.; Li, Y.; Davis, H.; Kanda, T.; Shimizu, F.; Taams, L. S.; Denk, F.
10.1101/2024.12.11.627455 — neuroscience — Posted on 2025-03-19
1973 Exploring fern pathosystems and immune receptors to bridge gaps in plant immunity
Castel, B.; Baker, M.; Keller, J.; Martinez, Y.; Bonhomme, M.; Delaux, P.-M.; Jacquet, C.
10.1101/2025.03.18.643875 — plant biology — Posted on 2025-03-19
1974 A tomato line hyposensitive to simulated proximity shade shows altered auxin-related 1 gene expression and improved fruit yield under high-density field conditions
Burbano, E.; Francesca, S.; Palau-Rodriguez, J.; Berdonces, A.; Valverde-Carbajal, L.; Perez-Beser, J. M.; Addonizio, M.; MARTINEZ GARCIA, J.; Rigano, M. M.; Rodriguez-Concepcion, M.
10.1101/2025.03.18.643865 — plant biology — Posted on 2025-03-19
1977 The Global Wheat Full Semantic Organ Segmentation (GWFSS) dataset
Wang, Z.; Zenkl, R.; Greche, L.; De Solan, B.; Bernigaud Samatan, L.; Ouahid, S.; Visioni, A.; Robles-Zazueta, C. A.; Pinto, F.; Perez-Olivera, I.; Reynolds, M. P.; Zhu, C.; Liu, S.; D'argaignon, M.-P.; Lopez-Lozano, R.; Weiss, M.; Marzougui, A.; Roth, L.; Dandrifosse, S.; Carlier, A.; Dumont, B.; Mercatoris, B.; Fernandez, J.; Chapman, S.; Najafian, K.; Stavness, I.; Wang, H.; Guo, W.; Virlet, N.; Hawkesford, M.; Chen, Z.; David, E.; Gillet, J.; Irfan, K.; Comar, A.; Hund, A.
10.1101/2025.03.18.642594 — plant biology — Posted on 2025-03-19
1980 Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone
Shimizu, H.; Wang, L.; Tsuda, M.; Maruyama, R.; Saitoh, Y.; Kumegawa, K.; Takahashi, M.; Horii, R.; Suzuki, H.; Watanabe, K.; Arai, R.; Murakami, M.; Iwasaki, N.; Tanaka, S.
10.1101/2025.03.18.643632 — cancer biology — Posted on 2025-03-19
1981 SOX2 empowers a rapid tumorigenic programme from the tumour resistant population in the skin
Centeno, P. P.; Chester, C.; Ford, C. A.; Ridgway, R. A.; Cammareri, P.; Jamieson, T.; Marais, R.; Campbell, A. D.; Sansom, O. J.
10.1101/2025.01.23.634502 — cancer biology — Posted on 2025-03-19
1983 Transposable Element Expression and Sub-cellular Dynamics During hPSC Differentiation to Endoderm, Mesoderm, and Ectoderm Lineages
Babarinde, I. A.; Fu, X.; Ma, G.; Li, Y.; Oleynikova, K.; Akinwole, M.; Zhou, X.; Ruzov, A.; Hutchins, A. P.
10.1101/2024.07.03.602001 — genomics — Posted on 2025-03-19
1984 Unraveling genetic load dynamics during biological invasion: insights from two invasive insect species
Lombaert, E.; Blin, A.; Porro, B.; Guillemaud, T.; Bernal, J. S.; Chang, G.; Kirichenko, N.; Sappington, T. W.; Toepfer, S.; Deleury, E.
10.1101/2024.09.02.610743 — evolutionary biology — Posted on 2025-03-19
1987 Feature similarity: a sensitive method to capture the functional interaction of brain regions and networks to support flexible behavior
Wang, X.; Lyu, B.; Krieger-Redwood, K.; Souter, N. E.; Shafiei, G.; Lin, N.; Smallwood, J.; Jefferies, E.; Du, Y.
10.1101/2024.11.13.623324 — neuroscience — Posted on 2025-03-19
1988 Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats
Lalanza, J. F.; Oyem, J. C.; Huijgens, P. T.; McCutcheon, J. E.; Heijkoop, R.; Snoeren, E. M. S.
10.1101/2024.10.14.618156 — neuroscience — Posted on 2025-03-19
1995 Cumulative pregnancy and postnatal environmental exposures impact social behaviour in male mice associated with epigenetic, ribosomal, and immune dysregulation
Bucknor, M. C.; Keating, B. A.; Han, V. X.; Gloss, B. S.; Dey, P.; Aryamanesh, N.; Marshall, L. L.; Graham, M. E.; Dissanayake, R.; Lau, X.; Patel, S.; Petkova, S. P.; Gururajan, A.; Dale, R. C.; Hofer, M. J.
10.1101/2025.03.19.644073 — developmental biology — Posted on 2025-03-19
1996 The RRM domain-containing protein Rbp3 interacts with ribosomes and the 3' ends of mRNAs encoding photosynthesis proteins
Hemm, L.; Lichtenberg, E.; Tholen, S.; Reimann, V.; Kakazu, K.; Machida, S.; Mahbub, M.; Schilling, O.; Wilde, A.; Watanabe, S.; Mullineaux, C. W.; Hess, W. R.
10.1101/2024.07.09.602696 — microbiology — Posted on 2025-03-19
1997 The Role of Syllabic Rhythm in Speech Perception Across Languages
de la Cruz-Pavia, I.; Villegas, J.; Nallet, C.; Iwamoto, K.; Guevara, R.; Gervain, J.
10.1101/2025.03.18.643971 — neuroscience — Posted on 2025-03-19
1998 Addressing cultural and knowledge barriers to enable preclinical sex inclusive research
Gaskill, B. N.; Phillips, B.; Ho, J.; Rafferty, H.; Olajide Onada, O.; Rooney, A.; Ahluwalia, A.; Karp, N. A.
10.1101/2025.03.18.643949 — scientific communication and education — Posted on 2025-03-19
1999 Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features
Li, J.; Macchia, J.; Elhossiny, A. M.; Arya, N.; Kadiyala, P.; Branch, G. L.; Peterson, N.; Liu, J.; Kwon, R.; Machicado, J. D.; Wamsteker, E.-J.; Schulman, A.; Philips, G.; Menees, S.; Singhi, A. D.; Sahai, V.; Fang, J. M.; Frankel, T. L.; Bednar, F.; Pasca di Magliano, M.; Shi, J.; Carpenter, E. S.
10.1101/2025.03.18.643943 — cancer biology — Posted on 2025-03-19
2001 Multidimensional characterization of cellular ecosystems in Hodgkin lymphoma
AOKI, T.; Duns, G.; Rai, S.; Jiang, A.; Lytle, A.; Yin, Y.; Kishida, M.; Li, M.; Smorra, D.; Hilton, L.; Alig, S. K.; Esfahani, M. S.; Sarkozy, C.; Hung, S.; Milne, K.; Telenius, A.; O`Brien, L.; Strong, C.; Goodyear, T.; Vito, C. D.; Luksik, C.; Edin, G.; Gonzalez, L.; Rangel, J. P.; Hong, M.; Wu, S.; Lee, E.; Takata, K.; Miyata-Takata, T.; Boyle, M.; Ben-Neriah, S.; Weng, A. P.; Xu, A.; Merchant, A.; Roth, A.; Crump, M.; Kuruvilla, J.; Prica, A.; Kridel, R.; Huntsman, D.; Nelson, B. H.; Farinha, P.; Morin, R. D.; Alizadeh, A.; Savage, K. J.; Scott, D. W.; Steidl, C.
10.1101/2025.03.18.643177 — cancer biology — Posted on 2025-03-19
2003 IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites
Miller, J. P.; Kim, K.; Khazan, N.; Snyder, C. W.; Singh, N. A.; Lamere, E.; Strawderman, M.; Sharma, S.; Lakony, R.; Whittum, M.; Anderson, M.; Keenan, R.; Pichard, E.; Baker, C.; Ashton, J.; Khera, M. K.; Chu, C. C.; Bajaj, J.; Elliott, M. R.; Rowswell-Turner, R.; Calvi, L. M.; Becker, M. W.; Moore, R. G.; Singh, R. K.
10.1101/2025.03.18.643950 — cancer biology — Posted on 2025-03-19
2004 The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis
Gomez-Munoz, M. A.; Karz, A.; Navarro, M.; Osorio-Vasquez, V. M.; Katsara, O.; Walker, A.; Berico, P.; Medellin, A. P.; Eskow, N. M.; Wan, Y.; Ibrahim, M.; Tagore, S.; DSouza, E. K.; Izar, B.; Vega-Saenz de Miera, E.; Osman, I.; Pacold, M.; Kong, X.; Levesque, M.; Possemato, R.; Holmen, S.; Schneider, R.; Vincent, T.; Ruggles, K.; Biancur, D.; Hernando, E.
10.1101/2025.03.18.644053 — cancer biology — Posted on 2025-03-19
2005 Acquired resistance to sotorasib in mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1 regulator of cap-dependent translation
MERAZ, I. M.; Wu, S.; Xu, Y.; Gao, L.; Feng, M.; Ren, C.; Song, R.; Zhang, R.; Wang, Q.; Xi, Y.; Jung, S. Y.; Wang, J.; Fang, B.; Majidi, M.; Roth, J. A.
10.1101/2025.03.18.643954 — cancer biology — Posted on 2025-03-19
2008 Soleus H-reflex size versus stimulation rate in the presence of background muscle activity: A methodological study
Brangaccio, J. A.; Gupta, D.; Mojtabavi, H.; Hardesty, R. L.; Hill, N. J.; Carp, J. S.; Gemoets, D.; Vaughan, T. M.; Norton, J. J. S.; Perez, M.; Wolpaw, J. R.
10.1101/2025.03.17.643784 — neuroscience — Posted on 2025-03-19
2009 A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity
Joly, A.; Popmihaylova, A.-M.; Rancurel, C.; Soltys, J.; Fritsch, L.; Loudhaief, R.; Gallet, A.; Foley, E.; Martinez, A.-M.; Rousset, R.
10.1101/2025.03.18.643963 — cancer biology — Posted on 2025-03-19
2010 Adhesion-driven tissue rigidification triggers epithelial cell polarity
Rustarazo-Calvo, L.; Pallares-Cartes, C.; Aguirre-Tamaral, A.; Floris, E.; Hingerl, M.; Autorino, C.; Khan, A. U. M.; Corominas-Murtra, B.; Petridou, N. I.
10.1101/2025.03.18.644006 — biophysics — Posted on 2025-03-19
2013 Volumetric printed biomimetic scaffolds support in vitro lactation of human milk-derived mammary epithelial cells
Hasenauer, A.; Bevc, K.; McCabe, M. C.; Chansoria, P.; Saviola, A. J.; Hansen, K. C.; Christman, K. L.; Zenobi-Wong, M.
10.1101/2025.03.18.643642 — bioengineering — Posted on 2025-03-19
2014 Restoration of tumor suppressor protein with enhanced activity using engineered tRNAs to induce tumor regression
Kong, B.; Zheng, Z.; Mi, Z.; Dou, Z.; Yang, Y.; Shen, Y.; Dong, L.; Lv, J.; Li, Y.; Liang, Q.; Tian, S.; Wang, J.; Qiao, H.; Xia, Q.
10.1101/2025.03.18.643282 — bioengineering — Posted on 2025-03-19
2015 Genomic prediction of agronomic traits in perennial ryegrass (Lolium perenne L.) and genotype x environment interactions at the limit of the species distribution
Johansen, N. H.; Bellucci, A.; Hansen, P. B.; Marum, P.; Amdahl, H.; Gylstrom, K. H.; Rognli, O. A.; Kemesyte, V.; Brazauskas, G.; Greve, M.; Persson, C.; Isolahti, M.; Helgadottir, A.; Aavola, R.; Asp, T.; Ramstein, G.
10.1101/2025.03.18.642199 — genetics — Posted on 2025-03-19
2017 A novel tool for optogenetic control of Islets of Langerhans: The Optopus Box
Acreman, S.; Arturen, A.; Hagser, A.; Hermasson, A.; Huke, V.; Dou, H.; Tolo, J.; Miranda, C.
10.1101/2025.03.18.643880 — cell biology — Posted on 2025-03-19
2019 The Stmn1-lineage contributes to acinar regeneration but not to neoplasia upon oncogenic Kras expression
Dahiya, S.; Reyes Arbujas, J.; Hajihassani, A.; Amini, S.; Wageley, M.; Gurbuz, K.; Ma, Z.; Copeland, C.; Saleh, M.; Gittes, G. K.; Koo, B.-K.; DelGiorno, K. E.; Esni, F.
10.1101/2025.03.18.643944 — cell biology — Posted on 2025-03-19
2020 MIR192 Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion
Kuang, Y.-L.; Locatelli, C. A. A.; Qin, Y.; Zhang, Y.; Theusch, E.; Munoz-Howell, A.; Sanchez, G.; Lu, M.; Nguyen, M.-A.; Yalamanchili, T.; Wang, X.; Nalula, G.; Mattis, A. N.; Oni-Orisan, A.; Iribarren, C.; Krauss, R. M.; Mulvihill, E. E.; Medina, M. W.
10.1101/2025.03.18.643960 — cell biology — Posted on 2025-03-19
2021 Chlamydomonas γ-tubulin mutations reveal a critical role of γ-TuRC in maintaining the stability of centriolar microtubules
Nakazawa, Y.; Horii, M.; Noga, A.; Koike, Y.; Kawai-Toyooka, H.; Dohra, H.; Yamaguchi, K.; Shigenobu, S.; Wakabayashi, K.-i.; Hirono, M.
10.1101/2025.03.18.643570 — cell biology — Posted on 2025-03-19
2022 Analysis of patient data reveals novel cancer-relevant functions for GCN2/eIF2αK4
Stonyte, V.; Fjeldbo, C. S.; Swaminathan, P.; Humagain, P. S.; Pesquera, L. M. V.; Lindbergsengen, L.; Lyng, H.; Grallert, B.
10.1101/2025.03.18.643965 — cell biology — Posted on 2025-03-19
2023 Extracellular matrix deposition controls early differentiation patterns in human cardiac gastruloids
Marchand, M. F.; Sahni, G.; Arora, A.; Sehrouchni, S.; Dilasser, F.; Monet, A.; Luciani, F.; Rajendiran, H.; Chabot, L.; Mohamad Raffi, S. B.; Grenci, G.; Sibarita, J.-B.; Galland, R.; Zhu, J.; Viasnoff, V.
10.1101/2025.03.18.643854 — cell biology — Posted on 2025-03-19
2025 Defining the role of fibroblasts in skin expansion
Aguilera Stewart, C.; Alar, C.; Bargsted, L.; Kaklamanou, I.; Gozza, G. A.; Polito, M. P.; Enzo, E.; Sifrim, A.; Aragona, M.
10.1101/2025.03.18.643853 — cell biology — Posted on 2025-03-19
2026 Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization
Shajahan, S.; Loe-Mie, Y.; Salmon-Legagneur, M.; Traboulsi, T.; Thierry, A.; Dejean, A.; Cossec, J.-C.
10.1101/2025.03.18.643869 — cell biology — Posted on 2025-03-19
2028 An early functional adaptive NK cell signature drives optimal CD8+ T-cell activation and predicts sustained HIV-1 viral control.
Alrubayyi, A.; Hassan, A.; Hare, J.; Hsieh, A.; Gilmour, J.; Price, M. A.; Kilembe, W.; Karita, E.; Ruzagira, E.; Esbjornsson, J.; Sanders, E. J.; Peppa, D.; Rowland-Jones, S.
10.1101/2025.03.17.643703 — immunology — Posted on 2025-03-19
2029 Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort
Bertran-Cobo, C.; Robertson, F. C.; Kangwa, T. S.; Annandale, J.; Subramoney, S.; Narr, K. L.; Joshi, S. H.; Hoffman, N.; Zar, H. J.; Stein, D. J.; Donald, K. A.; Wedderburn, C. J.; Naude, P. J.
10.1101/2025.03.17.643628 — neuroscience — Posted on 2025-03-19
2033 Hitting the right pitch: Cortical tracking of fundamental frequency changes across speech rates in auditory and sensorimotor regions
Mantilla-Ramos, Y.-J.; Hincapie-Casas, A.-S.; Pascarella, A.; Lajnef, T.; Leahy, R. M.; Coffey, E.; Jerbi, K.; Boulenger, V.
10.1101/2025.03.18.644060 — neuroscience — Posted on 2025-03-18
2034 Second-Scale Neural Dynamics Shape Hormonal Outputs in Hypothalamic CRH Neurons
Igarashi, H.; Mestern, S.; Ichiyama, A.; Vijayraghavan, S.; Martinez-Trujillo, J. C.; Ramachandran, R.; Inoue, W.
10.1101/2025.03.18.641872 — neuroscience — Posted on 2025-03-18
2037 A high-resolution subcellular map of proteins in ciliated cells
Bertilsson, F.; Hikmet, F.; Hansen, J. N.; Uhlen, M.; Mear, L.; Lindskog, C.
10.1101/2025.03.18.643967 — cell biology — Posted on 2025-03-18
2038 Visualization of functional and effective connectivity underlying auditory descriptive naming
Kitazawa, Y.; Sakakura, K.; Uda, H.; Kuroda, N.; Ueda, R.; Firestone, E.; Lee, M.-H.; Jeong, J.-W.; Sonoda, M.; Osawa, S.-i.; Ukishiro, K.; Ishida, M.; Kakinuma, K.; Ota, S.; Takayama, Y.; Iijima, K.; Kambara, T.; Endo, H.; Suzuki, K.; Nakasato, N.; Iwasaki, M.; ASANO, E.
10.1101/2025.03.18.644036 — neuroscience — Posted on 2025-03-18
2039 Sex-specific and age-related progression of auditory neurophysiological deficits in the Cln3 mouse model of Batten disease
Ding, Y.; Feng, J.; Prifti, V.; Rico, G.; Solorzano, A. G.; Chang, H. E.; Freedman, E. G.; Foxe, J. J.; Wang, K. H.
10.1101/2025.03.18.643722 — neuroscience — Posted on 2025-03-18
2042 Origins and evolutionary trajectories of morbilliviruses in Neotropical bats
Jo, W. K.; Moreira-Soto, A.; Campos, A. A.; Goes, L. G. B.; Mares-Guia, M. A.; Rasche, A.; Bispo de Filippis, A.; Hernandez-Mora, G.; Nambulli, S.; Streicker, D.; Duprex, W. P.; Drexler, J. F.; bat morbillivirus consortium,
10.1101/2025.03.18.643905 — microbiology — Posted on 2025-03-18
2043 Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans
Mota, C.; Kim, K.; Son, Y. J.; Thak, E. J.; Lee, S.-B.; Kim, J.-E.; Yoon, J.-K.; Kang, M.-H.; Hwang, H.; Bahn, Y.-S.; Alspaugh, A.; Kang, H. A.
10.1101/2024.09.24.610715 — microbiology — Posted on 2025-03-18
2044 Discovery of neuronal cell types by pairing whole cell reconstructions with RNA expression profiles
Ferreira, T. A.; Eddison, M.; Copeland, M.; Lay, M.; Tenshaw, E.; Weldon, M.; Schauder, D.; Olbris, D. J.; Rokicki, K.; Spruston, N.; Tillberg, P. W.; Chandrashekar, J.; Korff, W.; Dudman, J. T.; The MouseLight Project Team,
10.1101/2024.12.30.630829 — neuroscience — Posted on 2025-03-18
2046 Sympathetic Vasomotion Reflects Catheter-based Radiofrequency Renal Denervation
Pellegrino, P. R.; Zucker, I. H.; Schiller, A. M.; Wang, H.; Chatzizisis, Y. S.
10.1101/2025.03.17.643831 — physiology — Posted on 2025-03-18
2047 Sequence Clustering Enhances AlphaFold2
Wayment-Steele, H. K.; Ovchinnikov, S.; Colwell, L.; Kern, D.
10.1101/2024.07.29.605333 — biophysics — Posted on 2025-03-18
2049 Dissecting a biological electron transport network with electrochemistry
Lawrence, J. M.; Egan, R. M.; Wey, L. T.; Bali, K.; Chen, X.; Kosmützky, D.; Eyres, M.; Nan, L.; Wood, M. H.; Nowaczyk, M. M.; Howe, C. J.; Zhang, J. Z.
10.1101/2025.03.18.643929 — biochemistry — Posted on 2025-03-18
2050 Comprehensive 16S rRNA gene sequencing and meta-transcriptomic analyses in female reproductive tract microbiota: Two molecular profiles with different messages
Sola-Leyva, A.; Perez-Prieto, I.; Canha-Gouveia, A.; Salas-Espejo, E.; Molina, N.; Vargas, E.; Apostolov, A.; Pathare, A. D.; Vela-Moreno, S.; Ruiz-Duran, S.; Romero, B.; Sanchez, R.; Castilla-Alcala, J. A.; Saare, M.; Acharya, G.; Salumets, A.; Altmae, S.
10.1101/2025.03.18.643876 — genomics — Posted on 2025-03-18
2054 Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing
Saini, N.; Vijayraghavan, S.; Ruggiero, A.; Becker, S.; Mieczkowski, P.; Hanna, G. S.; Hamann, M. T.
10.1101/2025.03.18.643935 — genetics — Posted on 2025-03-18
2059 Floating offshore wind farms cause Japanese horse mackerel to congregate
Tsuchida, S.; Kato, R.; Nishitsuji, S.; Anzai, S.; Azmi, S. S. B.; Tanaka, S.; Masumi, S.; Uchida, J.; Aoshima, T.; Hirasaka, K.; Fujimoto, S.; Shimizu, K.; Hirose, M.; Yagi, M.
10.1101/2025.03.17.643605 — ecology — Posted on 2025-03-18
2061 Productivity of Pleurotus ostreatus on lignocellulosic Rice Husk substrate supplemented with Sugar Industry Residual Biomass
Hernandez Garcia, E. M.; Romero Morales, J. J.; Sanchez Purihuaman, M. N.; BARTUREN QUISPE, A. P.; Cordova Rojas, L. M.; Huangal Scheineder, S.; Vasquez Llanos, S. A.; Carreno Farfan, C. R.
10.1101/2025.03.17.643815 — ecology — Posted on 2025-03-18
2065 Regulation of alternative polyadenylation events by PABPC1 affects erythroid progenitor cell expansion
Li, Y.; Yang, Y.; Hu, B.; Wang, Z.; Wang, W.; He, X.; Wu, X.; Lin, S.; Mohandas, N.; Liu, H.; Gong, J.; Liang, L.; Liu, J.
10.1101/2025.03.17.643825 — developmental biology — Posted on 2025-03-18
2066 Wnt signaling restores evolutionary loss of regenerative potential in Hydra
Campos, S. E.; Naziri, S.; Crane, J.; Tsverov, J.; Cox, B. D.; Ciampa, C.; Juliano, C. E.
10.1101/2025.03.18.643955 — developmental biology — Posted on 2025-03-18
2071 Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement
Walker, M. W. G.; Akematsu, T.; Aslan, E.; Villano, D. J.; Fried, H. S.; Lan, H.; Sternberg, S. H.; Landweber, L.
10.1101/2025.03.17.643836 — molecular biology — Posted on 2025-03-18
2074 FRUCTOSE ACTIVATES A STRESS RESPONSE SHARED BY METHYLGLYOXAL AND HYDROGEN PEROXIDE IN STREPTOCOCCUS MUTANS
Walker, A. R.; Pham, D. N.; Noeparvar, P.; Peterson, A. M.; Lipp, M. K.; Lemos, J. A.; Zeng, L.
10.1101/2024.10.26.620100 — microbiology — Posted on 2025-03-18
2075 Pulcherriminic acid biosynthesis and Transport: Insights from a heterologous system in Saccharomyces cerevisiae
Macia Valero, A.; van Wageningen, J. J.; Foster, A. J.; Oliveira, A. R.; Mayer, C.; Billerbeck, S.
10.1101/2025.03.18.643849 — microbiology — Posted on 2025-03-18
2078 Emergence of ST3390: A non-pigmented HA-MRSA clone with enhanced virulence
Felton, E. A.; Jobson, M.-E.; Virgillio, A.; Alvior, J.; Cella, E.; Lima, A.; Becker, D.; Silbert, S.; Azarian, T.; Kim, K.; Shaw, L. N.
10.1101/2025.03.18.643911 — microbiology — Posted on 2025-03-18
2079 Modular automated high-throughput isolation and phylogenetic identification of bacteria from complex microbiomes
Chaboy-Cansado, R.; Talavera-Marcos, S.; Gallego-Simon, R.; Cobeta, P.; Roscales, G.; Rastrojo, A.; Aguirre de Carcer, D.
10.1101/2025.03.18.643884 — microbiology — Posted on 2025-03-18
2082 DNA-utilization loci enable exogenous DNA metabolism in gut Bacteroidales
Sharan, D.; Nurek, A.; Stemczynski, J.; Turan, K.; Coyne, M. J.; McMillin, M.; Sidebottom, A. M.; Comstock, L. E.; Light, S. H.
10.1101/2025.03.18.642099 — microbiology — Posted on 2025-03-18
2084 Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickens
Scheibner, D.; Lang, J.; Luttermann, C.; Palme, D. I.; Franzke, K.; Helke, D.; Kuryshko, M.; Fatola, O. I.; Richard, M.; Veits, J.; Mettenleiter, T. C.; Ulrich, R.; Abdelwhab, E. M.
10.1101/2025.03.18.643940 — microbiology — Posted on 2025-03-18
2087 Redirecting TCR specificity in regulatory T cells toward class I HLA antigens mediates tissue-specific homing
Porret, R.; Lebreton, F.; Stefanidis, E.; Semilietof, A.; Guillaume, P.; Georgakis, S.; Pace, E.; Alfageme-Abello, O.; Alcaraz-Serna, A.; Ermellino, L.; Cecchin, R.; Lana, E.; Giordano-Attianese, G.; Zoete, V.; Petrovas, C.; Irving, M.; Berishvili, E.; Tang, Q.; Muller, Y. D.
10.1101/2025.03.17.643496 — immunology — Posted on 2025-03-18
2088 Development of a thermostable and broadly neutralizing pan-sarbecovirus vaccine candidate
Srivastava, S.; Kumar, S.; Mishra, S.; Rajmani, R. S.; Singh, R.; Dutta, S.; Ringe, R. P.; Varadarajan, R.
10.1101/2025.03.17.643667 — immunology — Posted on 2025-03-18
2089 Flagellin nebulization enhances respiratory immune responses in the porcine model
Baldry, M.; Caballero, I.; Ruuls, L.; Cayet, D.; Zeroual, Y.; Costa, C.; Beury, D.; Hot, D.; Le Vern, Y.; Heuze-Vourch, N.; MacLoughlin, R.; Benecke, A. G.; Stockhofe-Zurwieden, N.; Sirard, J.-C.
10.1101/2025.03.17.643810 — immunology — Posted on 2025-03-18
2090 Commensal-derived Trehalose Monocorynomycolate Triggers γδ T Cell-driven Protective Ocular Barrier Immunity
Xu, X.; Rigas, Y. E.; Mattapallil, M. J.; Guo, J.; Nagarajan, V.; Bohrnsen, E.; Richards, C.; Gupta, A.; Gaud, G.; Love, P. E.; Jiang, T.; Zhang, A.; Xu, B.; Peng, Z.; Jittayasothorn, Y.; Carr, M.; Magone, M. T.; Brandes, N. T.; Shane, J.; Schwarz, B.; St. Leger, A. J.; Caspi, R.
10.1101/2025.03.17.643820 — immunology — Posted on 2025-03-18
2091 Circuit dynamics of approach-avoidance conflict in humans
Staveland, B. R.; Oberschulte, J.; Berger, B.; Minarik, T.; Kim-McManus, O.; Willie, J. T.; Brunner, P.; Dastjerdi, M.; Lin, J. J.; Hsu, M.; Knight, R. T.
10.1101/2024.12.31.630927 — neuroscience — Posted on 2025-03-18
2092 Pathological microcircuits and epileptiform events in patient hippocampal slices
Elliott, M.; Andrews, J. P.; Molen, T. v. d.; Geng, J.; Spaeth, A.; Toledo, A.; Voitiuk, K.; Core, C.; Gillespie, T.; Sinervo, A.; Parks, D. F.; Robbins, A.; Solis, D.; Chang, E. F.; Nowakowski, T. J.; Teodorescu, M.; Haussler, D.; Sharf, T.
10.1101/2024.11.13.623525 — neuroscience — Posted on 2025-03-18
2095 An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes
Furlanis, E.; Dai, M.; Leyva Garcia, B.; Vergara, J.; Tran, T.; Pereira, A.; Gorissen, B. L.; Wills, S.; Vlacho, A.; Hairston, A.; Dwivedi, D.; Du, S.; McMahon, J.; Huang, S.; Morabito, A.; Vazquez, A.; Kim, S.; Lee, A. T.; Chang, E. F.; Razzaq, T.; Qazi, A.; Vargish, G.; Yuan, X.; Caccavano, A.; Hunt, S.; Chittajallu, R.; McLean, N.; Hewit, L.; Paranzino, E.; Rice, H.; Cummins, A. C.; Plotnikova, A.; Mohanty, A.; Tangen, A. C.; Shin, J. H.; Azadi, R.; Eldridge, M. A. G.; Alvarez, V. A.; Averbeck, B. B.; Alyahyay, M.; Reyes Vallejo, T.; Soheib, M.; Vattino, L. G.; MacGregor, C. P.; Chatain, C.
10.1101/2024.07.17.603924 — neuroscience — Posted on 2025-03-18
2097 Atrophin-1 Antisense Oligonucleotide Provides Robust Protection from Pathology in a Fully Humanized DRPLA Model
Smith, V. L.; Gidi, B. Z.; Bragg, R. M.; Cantle, J. P.; Ben-Varon, A.; Nobel, B.; Prades, S.; Compton, A.; Greenfield, J.; Korecka-Roet, J.; Yu, T.; Khurana, V.; Kordasiewicz, H. B.; Zhao, H. T.; Barker-Haliski, M.; Child, D. D.; Carroll, J. B.
10.1101/2025.03.18.643143 — neuroscience — Posted on 2025-03-18
2098 Utility of the Recombinase Driver CX3CR1::Cre Rat Strain to Evaluate Microglial Contributions to Nicotine Addiction
White, A. M.; Craig, A. J.; Richie, D. L.; Corley, C. L.; Bondy, E. O.; Kendrick, P. T.; Scofield, M. M.; Sadek, S. M.; Gipson, C. D.; McManus, H.
10.1101/2025.03.18.643780 — neuroscience — Posted on 2025-03-18
2102 KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease
Samidurai, M.; Chennakesavan, K.; Sarkar, S.; Malovic, E.; Nguyen, H. M.; Singh, L.; Kumar, A.; Ealy, A.; Janarthanam, C.; Palanisamy, B. N.; Kondru, N.; Zenitsky, G.; Jin, H.; Anantharam, V.; Kanthasamy, A.; Zhang, H.; Wulff, H.; Kanthasamy, A.
10.1101/2025.03.18.643982 — neuroscience — Posted on 2025-03-18
2104 Overexpression of alpha synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice
Barcomb, K.; Hsiao, J.-T.; Lemak, J.; Zhuang, X.; Coutant, B.; Yanez, A.; Behal, A.; Fu, Y.; Lerner, T.; Nakamura, K.; Edwards, R.; Khaliq, Z. M.; Halliday, G.; Ford, C. P.; Nelson, A. B.
10.1101/2025.03.17.643840 — neuroscience — Posted on 2025-03-18
2107 Functional and structural profiling of circulation via genetically encoded modular fluorescent probes.
Vittani, M.; Lee, A. B.; Wang, X.; Hiraoka, Y.; Konno, A.; Knak, P. G.; Kusk, P.; Nagao, M.; Asiminas, A.; Courtin, J.; Putranto, M. F.; Nasu, Y.; Tsuno, S.; Ueda, K.; Osuga, Y.; Tsuboi, T.; Bienvenu, T.; Terunuma, M.; Hirai, H.; Nedergaard, M.; Tanaka, K.; Hirase, H.
10.1101/2025.03.18.643859 — neuroscience — Posted on 2025-03-18
2108 Genetic targeting of myelinated primary afferent neurons using a new NefhCreERT2 knock-in mouse
Chen, J. C.; Kaczmarczyk, L.; de Faria, F. M.; Szczot, M.; Jackson, W. S.; Larsson, M.
10.1101/2025.03.18.643951 — neuroscience — Posted on 2025-03-18
2111 Optimal Neuromuscular Performance Requires Motor Neuron Phosphagen Kinases
Justs, K. A.; Latner, D. V.; Oliva, C. D.; Arab, Y.; Bonassi, G. G.; Mahneva, O.; Crill, S.; Sempertegui, S.; Kirchman, P. A.; Fily, Y.; Macleod, G. T.
10.1101/2025.03.18.643998 — neuroscience — Posted on 2025-03-18
2112 Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction
Goniotaki, D.; Wulf, M.; Lynham, S.; Ale, A.; Chennell, G.; Marcotti, S.; Marcus, K.; Noble, W.; Hanger, D. P.; Fraser, G.; Srivastava, D. P.
10.1101/2025.03.18.643906 — neuroscience — Posted on 2025-03-18
2114 Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders
Davakan, A.; Cmarko, L.; Ribeiro, B.; Bernat, C.; Boulali, N.; Montnach, J.; Vallee, S. E.; Burglen, L.; Cantagrel, V.; Weiss, N.; Nicole, S.; Monteil, A.; De Waard, M.; LORY, P.
10.1101/2025.03.18.644009 — neuroscience — Posted on 2025-03-18
2115 Slow scission of single synaptic vesicles by Dynamin at physiological temperature
Klingauf, J.; Krishnan, S.; Lehrich, J.; Tsytsyura, Y.; Glyvuk, N.; Duan, J.
10.1101/2025.03.18.643914 — neuroscience — Posted on 2025-03-18
2118 Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms including sleep
Stoiljkovic, M.; Song, J. E.; Hong, H.-k.; Endle, H.; Varela, L.; Catarino, J.; Gao, X.-B.; Liu, Z.-W.; Diano, S.; Cedernaes, J.; Bass, J. T.; Horvath, T. L.
10.1101/2025.03.18.643991 — neuroscience — Posted on 2025-03-18
2121 Mechanistic Variability in Corneal Nerve Recovery Linked to Injury Type
Meneux, L.; Pernot, S.; Feret, N.; Girard, M.; Nhiri, N.; Miessen, E.; Jacquet, E.; Michon, F.
10.1101/2025.03.18.643516 — neuroscience — Posted on 2025-03-18
2122 WormID-Bench: A Benchmark for Whole-Brain Activity Extraction in C. elegans
Adhinarta, J.; Dong, J.; He, T.; Sprague, D.; Wan, J.; Lee, H. J.; Yu, Z.; Liu, P.; Lu, H.; Yemini, E.; Kato, S.; Varol, E.; Wei, D.
10.1101/2025.01.06.631621 — neuroscience — Posted on 2025-03-18
2123 mTORC1 activation drives astrocyte reactivity in cortical tubers and brain organoid models of TSC
Li, T. L.; Blair, J. D.; Yoo, T.; Grant, G. A.; Hockemeyer, D.; Porter, B. E.; Bateup, H. S.
10.1101/2025.02.28.640914 — neuroscience — Posted on 2025-03-18
2124 Sex differences in GLP-1 signaling across species
Roseberry, T.; Grossrubatscher, I.; Krausz, T.; Wang, Y.; Schwartz, M. W.; Tingley, D.
10.1101/2025.03.17.643822 — systems biology — Posted on 2025-03-18
2125 Deep Integrated Network Analysis: a data-driven tool to discover and characterize disease pathways in the liver
Quin, J. E.; Urrutia Iturritza, M.; Mosquera, K. D.; Hildebrandt, F. F. A.; Barrenas, F.; Ankarklev, J.
10.1101/2025.03.17.643687 — systems biology — Posted on 2025-03-18
2126 Integrated omics analysis reveals human milk oligosaccharide biosynthesis programs in human lactocytes
Nyquist, S. K.; Annepureddy, L. D.; Sejane, K.; Furst, A.; Trahan, G. D.; Rudolph, M. C.; Twigger, A.-J.; Bode, L.; Martin Carli, J.; Goods, B.
10.1101/2025.03.17.643803 — systems biology — Posted on 2025-03-18
2128 Biosensor-Driven Strain Engineering Reveals Key Cellular Processes for Maximizing Isoprenol Production in Pseudomonas putida
Menasalvas, J.; Kulakowski, S.; Chen, Y.; Gin, J. W.; Turumtay, E. A.; Apolonio, M. A.; Baral, N. R.; Rivier, A.; Yunus, I. S.; Garber, M. E.; Scown, C. D.; Adams, P. D.; Lee, T. S.; Blaby, I. K.; Baidoo, E. E. K.; Petzold, C. J.; Eng, T.; Mukhopadhyay, A.
10.1101/2025.03.18.643695 — synthetic biology — Posted on 2025-03-18
2131 Novel cytometry-based characterization of lysosomal storage disease affected patient's cells
LAURENT, M.; COSETTE, J.; PAVANI, G.; BAYOL, S.; JENNY, C.; HARB, R.; OUSTELANDT, J.; BRASSIER, A.; STOCKHOLM, D.; AMENDOLA, M.
10.1101/2025.03.18.643908 — pathology — Posted on 2025-03-18
2132 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA
Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.
10.1101/2024.11.25.625221 — paleontology — Posted on 2025-03-18
2133 Identification of a shared persistence program in triple-negative breast cancer across treatments and patients
Baudre, L.; Jouault, G.; Prompsy, P.; Saichi, M.; Gastineau, S.; Huret, C.; Sourd, L.; Dahmani, A.; Montaudon, E.; Dingli, F.; Loew, D.; Marangoni, E.; Marsolier, J.; Vallot, C.
10.1101/2025.03.17.643634 — cancer biology — Posted on 2025-03-18
2134 Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursors
Moussavi-Baygi, R.; Ryan, M. J.; Sim, W.; Hoelscher, S. B.; Luga, V.; Chandrakumar, A. A.; Hoes, L.; Cha, J.; Lee, Y. S.; Herm, K.; Doron, B.; Ding, C. K. C.; Stohr, B. A.; Jin, P.; Nadkarni, T.; Fang, X.; Haryono, M.; Nguyen, A.; Karthaus, W. R.; Sawyers, C.; Feng, F. Y.; Goodarzi, H.; Bose, R.
10.1101/2025.03.17.643814 — cancer biology — Posted on 2025-03-18
2138 Remodeling of self-assembled microvascular networks under long term flow
Floryan, M.; Cambria, E.; Blazeski, A.; Coughlin, M.; Wan, Z.; Offeddu, G.; Vinayak, V.; Kant, A.; Shenoy, V.; Kamm, R.
10.1101/2025.03.17.643791 — biophysics — Posted on 2025-03-18
2141 GIMMEcpg: Global Imputation of Mean CpG MEthylation in Real-time
Moghul, I.; Chai, N.; Pontikos, N.; Hardcastle, A.; Herrero, J.; Beck, S.
10.1101/2025.03.17.643746 — bioinformatics — Posted on 2025-03-18
2142 Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging
Howe, C. L.; Zhao, K. L. Y.; Verinaz-Jadan, H.; Song, P.; Barnes, S. J.; Dragotti, P. L.; Foust, A. J.
10.1101/2025.03.17.643718 — bioengineering — Posted on 2025-03-18
2148 β-nicotinamide mononucleotide production in Vibrio natriegens: a preliminary study
Tran, L. H.; Tran, P. V. T.; Pham, D. H. T.; Nguyen, G. T.; Nghiem, T. T.; Pham, A. D.; Pham, N. Q.; Le, T. T.; Nguyen, L. N.; Dang, M. T. N.; Tran, T. H.; Tran, K. V.; Le, H. Q.
10.1101/2025.03.17.643733 — bioengineering — Posted on 2025-03-18
2151 LC-MS analysis of RNA through hydrogen bonding of alkylamines
Ross, R. L.; Sutton, M. J.; Murphy, K.; Gamez, R.; Du, M.; Bartlett, M. G.
10.1101/2025.03.18.643832 — biochemistry — Posted on 2025-03-18
2152 New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands and transcriptional coregulators
Tambones, I.; Sagar, A.; Vankova, P.; Loginov, D.; Carivenc, C.; Rochel, N.; Bourguet, W.; Man, P.; Bernado, P.; le Maire, A.
10.1101/2025.03.18.643890 — biochemistry — Posted on 2025-03-18
2153 Visible-Light-Controlled Residue-Selective Cross-Linking for Deciphering Protein Complexes and Dynamic Protein-Protein Interactions in Live Cells
Xu, Y.; Hu, H.; Ran, Y.; Zhao, W.; Guo, A.-D.; Nie, H.-J.; Zhai, L.; Yin, G.-L.; Cheng, J.-T.; Tao, S.; Yang, B.; Tan, M.; Chen, X.-H.
10.1101/2025.03.18.643847 — biochemistry — Posted on 2025-03-18
2154 Identification of novel human topoisomerase III beta inhibitors
Mamun, Y.; Chadni, S. H.; Rayala, R.; Ferdous, S.; Pokhrel, R.; Nefzi, A.; Chapagain, P.; Tse-Dinh, Y.-C.
10.1101/2025.03.18.642440 — biochemistry — Posted on 2025-03-18
2155 Revealing the unexpected interplay between the Proteasome Activator PA200 and the immunoproteasome
Zivkovic, D.; Mourtada, F.; Sanchez Dafun, A.; Seda Yazgili, A.; Jansma, M.; Grygier, P.; Rawski, M.; Czarna, A.; Bohn, S.; Zak, K. M.; Reiling, N.; Zemke, L.; Guo, K.; Behr, J.; Burlet-Schiltz, O.; Popowicz, G. M.; Marcoux, J.; Meiners, S.; Bousquet, M.-P.
10.1101/2025.03.18.643936 — biochemistry — Posted on 2025-03-18
2156 Protein characterization of the soybean malic enzyme family to select metabolic targets for seed oil improvement
Badia, M. B.; Costa, J.; Zucchetti, J. I.; Pavlovic, T.; Calace, P.; Saigo, M.; Wheeler, M. C. G.
10.1101/2025.03.18.644018 — biochemistry — Posted on 2025-03-18
2159 Optimising 7T-fMRI for imaging regions of magnetic susceptibility
Frisby, S. L.; Correia, M. M.; Zhang, M.; Rodgers, C. T.; Rogers, T. T.; Ralph, M. A. L.; Halai, A. D.
10.1101/2025.03.17.643748 — neuroscience — Posted on 2025-03-18
2160 High-Quality Cell Capture Reveals Transcriptomic Changes After Single-Axon Injury of Mauthner Cells
Song, Z.; Zhu, L.; Shen, Y.; Yao, H.; Cai, Y.; Shi, L.; Chen, X.; Han, A.; Zhao, Z.; Qu, K.; Hu, B.
10.1101/2025.03.17.643681 — neuroscience — Posted on 2025-03-18
2161 POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons
Talbi, R.; Stincic, T. L.; Ferrari, K.; Ji Hae, C.; Walec, K.; Medve, E.; Gerutshang, A.; Leon, S.; McCarthy, E. A.; Ronnekleiv, O. K.; Kelly, M. J.; Navarro, V. M.
10.1101/2024.02.18.580873 — neuroscience — Posted on 2025-03-18
2163 An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q
Smits, P.; Marrs, L.; Cheng, Y. S.; Ad, M.; Nasim, S.; Zurakowski, D.; Bischoff, J.; Greene, A. K.
10.1101/2025.03.17.643802 — cell biology — Posted on 2025-03-18
2165 Sex differences in GLP-1 signaling across species
Roseberry, T.; Grossrubatscher, I.; Krausz, T.; Wang, Y.; Schwartz, M. W.; Tingley, D.
10.1101/2025.03.17.643822 — systems biology — Posted on 2025-03-18
2166 Amino acid repeat signatures underlying human-pathogen interactions
Singh, A. K.; Rachote, N.; Agrawal, A.; Sharma, V.; Kappagantula, K. S.; Kadumuri, R. V.; Chavali, S.
10.1101/2025.03.17.643713 — systems biology — Posted on 2025-03-18
2167 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA
Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.
10.1101/2024.11.25.625221 — paleontology — Posted on 2025-03-18
2168 Revealing protein sequence organization via contiguous hydrophobicity with the blobulator toolkit
Pitman, C.; Santiago-McRae, E.; Lohia, R.; Lamb, R.; Bassi, K.; Riggs, L.; Joseph, T. T.; Hansen, M. E. B.; Brannigan, G.
10.1101/2024.01.15.575761 — bioinformatics — Posted on 2025-03-18
2169 Modelling Eurasian lynx populations in Western Europe: What prospects for the next 50 years?
Bauduin, S.; Germain, E.; Zimmermann, F.; Idelberger, S.; Herdtfelder, M.; Heurich, M.; Kramer-Schadt, S.; Duchamp, C.; Drouet-Hoguet, N.; Morand, A.; Blanc, L.; Charbonnel, A.; Gimenez, O.
10.1101/2021.10.22.465393 — ecology — Posted on 2025-03-18
2170 What lurks in the dark? - An innovative framework for studying diverse wild insect microbiota
Nowak, K. H.; Hartop, E.; Prus-Frankowska, M.; Buczek, M.; Kolasa, M.; Roslin, T.; Ovaskainen, O. T.; Łukasik, P.
10.1101/2024.08.26.609658 — ecology — Posted on 2025-03-18
2171 Decoding gene regulatory networks controlling hypothalamic and prethalamic development.
Kim, D. W.; Duncan, L.; Xu, J.; Chang, M.; Sorensen, S. S.; Terrillin, C.; Kanold, P.; Place, E. S.; Blackshaw, S.
10.1101/2025.01.10.632449 — neuroscience — Posted on 2025-03-18
2175 Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
Santambrogio, A.; Horne, R. I.; Metrick, M. A.; Brotzakis, Z. F.; Rinauro, D.; Vourkou, E.; Papanikolopoulou, K.; Skoulakis, E. M.; Linse, S.; Caughey, B.; Vendruscolo, M.
10.1101/2025.03.09.642189 — biophysics — Posted on 2025-03-18
2178 Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions
Cheloha, R. W.; Sachdev, S.; Roy, S.; Saha, S.; Zhao, G.; Kumariya, R.; Creemer, B. A.; Yin, R.; Pierce, B.; Bewley, C. A.
10.1101/2025.03.14.643405 — biochemistry — Posted on 2025-03-18
2179 Diversity and evolution of chromatin regulatory states across eukaryotes
Navarrete, C.; Montgomery, S. A.; Mendieta, J.; Lara-Astiaso, D.; Sebe-Pedros, A.
10.1101/2025.03.17.643675 — evolutionary biology — Posted on 2025-03-18
2180 The Language of Cancer: Decoding Cancer Signatures with Language Models and cfRNA Sequencing
Deng, S.; Sha, L.; Jin, Y.; Zhou, T.; Wang, C.; Liu, Q.; Guo, H.; Xiong, C.; Xue, Y.; Li, X.; Li, Y.; Gao, Y.; Hong, M.; Xu, J.; Chen, S.; Wang, P.
10.1101/2024.06.29.601341 — bioinformatics — Posted on 2025-03-18
2181 Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration
Chen, C.; Gao, T.-Y.; Yi, H.-W.; Zhang, Y.; Wang, T.; Lou, Z.-L.; Wei, T.-F.; Lu, Y.-B.; Li, T.; Tang, C.; Zhang, W.-P.
10.1101/2024.10.18.619025 — biochemistry — Posted on 2025-03-18
2185 Impacts of climate change on fonio millet: seed germination and suitability modelling of an important indigenous West African crop
Burton, G. P.; Mireku Botey, H.; Ceci, P.; Chater, C.; Gutaker, R. M.; Jackson, A. C.; Ryan, P.; Seal, C. E.; Turnbull, C. G. N.; Vorontsova, M. S.; Mattana, E.; Ulian, T.
10.1101/2025.03.14.641845 — plant biology — Posted on 2025-03-18
2186 Controlled and polygynous mating in the black soldier fly: advancing breeding programs utilizing quantitative genetic designs
Jensen, K.; Thormose, S. F.; Noer, N. K.; Schou, T. M.; Kargo, M.; Gligorescu, A.; Noergaard, J. V.; Hansen, L. S.; Zaalberg, R. M.; Nielsen, H. M.; Kristensen, T. N.
10.1101/2024.09.09.611978 — animal behavior and cognition — Posted on 2025-03-18
2187 Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability
Jocher, J.; Janssen, P.; Vieth, B.; Edenhofer, F. C.; Dietl, T.; Spurk, P.; Termeg, A.; Geuder, J.; Enard, W.; Hellmann, I.
10.1101/2024.12.12.628179 — cell biology — Posted on 2025-03-18
2189 Alterations in background ECoG activity and behavioral deficits in a mouse model of CHD2-related developmental delay
Mavashov, A.; Turk, S.; Sarusi, Y.; Brusel, M.; Ben Tov Perry, R.; Quinn, S.; Almog, Y.; Vilian, K.; Ulitsky, I.; Rubinstein, M.
10.1101/2025.03.18.643778 — neuroscience — Posted on 2025-03-18
2190 KinPFN: Bayesian Approximation of RNA Folding Kinetics using Prior-Data Fitted Networks
Scheuer, D.; Runge, F.; Franke, J. K. H.; Wolfinger, M. T.; Flamm, C.; Hutter, F.
10.1101/2024.10.15.618378 — bioinformatics — Posted on 2025-03-18
2191 WITHDRAWN: PROTON TRANSFER FROM BISPHENOL-A IS REQUIRED TO ACTIVATE EXTRANUCLEAR-INITIATED ESTROGEN RECEPTOR SIGNALING
Medina-Gali, R. M.; Martinez-Pinna, J.; Dos Santos, R. S.; Alonso-Magdalena, P.; Serrano-Maci, M.; Sempere-Navarro, R.; Soriano, S.; Fuentes-Paez, G.; Pasquali, L.; Mallavia, R.; Ciordia, S.; Grimaldi, M.; Balaguer, P.; Marroqui, L.; Nadal, A.
10.1101/2023.12.23.573228 — biochemistry — Posted on 2025-03-18
2192 Varicose-projection astrocytes: a reactive phenotype associated with neuropathology
Ciani, C.; Pistorio, G.; Giancola, S.; Mearelli, M.; Mongelli, F. E.; Forouzeh, D.; Mio, L.; Ramos-Gonzalez, P.; Matute, C.; Kuliesiute, U.; Dotterer, S. E.; Luksys, G.; Rocka, S.; Neniskyte, U.; Ayub, M.; Graic, J.-M.; Petrelli, F.; Verkhratsky, A.; Iraci, N.; Cavaliere, F.; Falcone, C.
10.1101/2025.03.17.643488 — neuroscience — Posted on 2025-03-18
2194 The Cortical Output System that Controls a Single Vibrissa Muscle
Maharjan, A.; Guest, J. M.; Rathelot, J.-A.; Gomez Osorio, F. M.; Strick, P. L.; Oberlaender, M.
10.1101/2025.03.18.643882 — neuroscience — Posted on 2025-03-18
2195 Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study
Bayer, J. M. M.; van Velzen, L. S.; Pozzi, E.; Davey, C.; Han, L. K. M.; Bauduin, S. E. E. C.; Bauer, J.; Benedetti, F.; Berger, K.; Bonnekoh, L. M.; Brosch, K.; Buelow, R.; Couvy-Duchesne, B.; Cullen, K. R.; Dannlowski, U.; Dima, D.; Dohm, K.; Evans, J. W.; Fu, C. H. Y.; Fuentes-Claramonte, P.; Godlewska, B. R.; Goltermann, J.; Gonul, A. S.; Gotlib, I. H.; Goya-Maldonado, R.; Grabe, H. J.; Groenewold, N. A.; Grotegerd, D.; Gruber, O.; Hahn, T.; Hall, G. B.; Hamilton, J. P.; Harrison, B. J.; Hatton, S. N.; Hermesdorf, M.; Hickie, I. B.; Ho, T. C.; Jahanshad, N.; Jamieson, A. J.; Jansen, A.; Ka
10.1101/2025.03.17.643677 — neuroscience — Posted on 2025-03-18
2196 Investigating the temporal dynamics and modelling of mid-level feature representations in humans
Karapetian, A.; Lenders, A.; Bawa, V.; Pflaum, M.; Leuner, R.; Roig, G.; Dwivedi, K.; Cichy, R. M.
10.1101/2025.03.18.643889 — neuroscience — Posted on 2025-03-18
2197 FMR1 KH0-KH1 Domains Coordinate m6A Binding and Phase Separation in Fragile X Syndrome
Zhou, X.; Guo, C.-J.; Wang, R.; Li, Y.; Zhang, T.; Qiu, Z.; Gao, S.; Liu, J.-L.; Gao, Y.
10.1101/2025.03.17.643701 — cell biology — Posted on 2025-03-18
2201 High-resolution fecal pharmacokinetic modeling in mice with orally administered antibiotics
Maskawa, R.; Takayasu, L.; Takayasu, H.; Watanabe, K.; Takemine, S.; Kakimoto, T.; Takeshita, K.; Narushima, S.; Suda, W.; Takayasu, M.
10.1101/2023.05.05.539495 — physiology — Posted on 2025-03-18
2203 Draft genome and transcriptomic sequence data of three invasive insect species
Lombaert, E.; Klopp, C.; Blin, A.; Annonay, G.; Iampietro, C.; Lluch, J.; Sallaberry, M.; Valiere, S.; Poloni, R.; Joron, M.; Deleury, E.
10.1101/2024.12.02.626401 — genomics — Posted on 2025-03-18
2206 Non-invasive assessment of integrated cardiorespiratory network dynamics after physiological stress in humans
Morandotti, C.; Rigny, L.; Williams, T. B.; Badariotti, J. I.; Miller-Dicks, M.; Bhogal, A. S.; Han, S.; Corbett, J.; Tipton, M. J.; Costello, J. T.; Mani, A.
10.1101/2025.03.17.643643 — physiology — Posted on 2025-03-18
2210 Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies
Wu, J.; Chu, S.-C. A.; Cho, J. W.; Movahed-Ezazi, M.; Galbraith, K.; Fang, C. S.; Yang, Y.; Schroff, C.; Sikkink, K.; Perez-Arreola, M.; Van Meter, L.; Gemus, S.; Belton, J.-M.; Nardi, V.; Louissant, A.; Shasha, D.; Tsirigos, A.; Brown, N.; Gindin, T.; Cieslik, M. P.; Kim, M.; Schmitt, A. D.; Snuderl, M.; Ryan, R. J. H.
10.1101/2025.03.15.643352 — genomics — Posted on 2025-03-18
2211 Epigenomic subtypes of late-onset Alzheimer's disease reveal distinct microglial signatures
Laroche, V. T.; Cavill, R.; Kouhsar, M.; Reijnders, R. A.; Harvey, J.; Smith, A. R.; Imm, J.; Koetsier, J.; Weymouth, L.; MacBean, L. F.; Pegoraro, G.; Eijssen, L.; Creese, B.; Kenis, G.; Tijms, B. M.; van den Hove, D.; Lunnon, K.; Pishva, E.
10.1101/2025.03.15.643144 — genomics — Posted on 2025-03-18
2212 Whole Genome Sequencing and Assembly of the House Sparrow, Passer domesticus
Kumar, V.; Sharma, G.; Sharma, S.; Prasad, S.; Vaishnani, T.; Vishnudasan, D.; Maheswaran, G.; Desai, S.; Tyagi, K.; Tyagi, I.; PB, K. K.; Chaubey, G.; Suravajhala, P.
10.1101/2023.11.04.565608 — evolutionary biology — Posted on 2025-03-18
2213 Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
Gekko, H.; Nomura, R.; Kuzuhara, D.; Kaneyasu, M.; Koseki, G.; Adhikari, D.; Mio, Y.; Carroll, J.; Kono, T.; Funahashi, H.; Wakai, T.
10.1101/2024.06.13.598818 — developmental biology — Posted on 2025-03-18
2215 A multiplex of connectome trajectories enables several connectivity patterns in parallel
Mostame, P.; Wirsich, J.; Alderson, T. H.; Ridley, B.; Giraud, A.-L.; Carmichael, D.; Vulliemoz, S.; Guye, M.; Lemieux, L.; Sadaghiani, S.
10.1101/2022.06.17.496647 — neuroscience — Posted on 2025-03-18
2220 Miniaturizing, Modifying, and Magnifying Nature's Proteins with Raygun
Devkota, K.; Shonai, D.; Mao, J.; Ko, Y. S.; Wang, W.; Soderling, S. H.; Singh, R.
10.1101/2024.08.13.607858 — bioinformatics — Posted on 2025-03-17
2221 KcatNet: A Geometric Deep Learning Framework for Genome-Wide Prediction of Enzyme Catalytic Efficiency
Pan, T.; Cui, X.; Koh, H. Y.; Bi, Y.; Wang, X.; Zhang, Y.; Hu, S.; Webb, G. I.; Kurgan, L.; Zhang, G.; Song, J.
10.1101/2025.03.09.642294 — bioinformatics — Posted on 2025-03-17
2222 Proteins are a source of glycans found in preparations of glycoRNA
Kegel, N. B.; Demirel, N. Y.; Glatter, T.; Höfer, K.; Kaufmann, A.; Bauer, S.
10.1101/2025.03.17.643711 — molecular biology — Posted on 2025-03-17
2223 Nested PCR to optimize rpoB metabarcoding for low-concentration and host-associated bacterial DNA
Leclerc, L.; Agoutin, G.; Brevault, T.; Champion, A.; Mainguy, J.; Negre, N.; Yainna, S.; Pascal, G.; Gaudriault, S.; OGIER, j. c.
10.1101/2025.03.17.643641 — microbiology — Posted on 2025-03-17
2224 Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular JIA
Wen, X.; Aulin, C.; Sundberg, E.; Qu, H.; Struglics, A.; Merritt, A.-S.; Melen, E.; Altman, M.; Harris, H. E.
10.1101/2025.03.17.643682 — immunology — Posted on 2025-03-17
2226 An OSMR-CLIC1 cross talk drives key oncogenic pathways in glioblastoma
Mansourabadi, A. H.; Randhawa, K.; Snider, J.; Qu, D.; Cianci, F.; Kotlyar, M.; Rey, G.; Raco, L.; Burger, D.; Rak, J.; Soleimani, V.; Jurisica, I.; Mazzanti, M.; Stagljar, I.; Jahani-Asl, A.
10.1101/2025.03.05.641563 — neuroscience — Posted on 2025-03-17
2228 A fast nociceptive subsystem mediating rapid reflexive behavior but not affective pain
Chen, J. C.; do Nascimento, L. F.; de Faria, F. M.; Carballo, G.; Kaczmarczyk, L.; Broman, J.; Nagi, S. S.; Olausson, H.; Jackson, W. S.; Szczot, M.; Larsson, M.
10.1101/2025.03.17.643731 — neuroscience — Posted on 2025-03-17
2229 Characterization and targeting of the endosomal signaling of the gastrin releasing peptide receptor in pruritus.
Retamal Santibanez, J.; Bok, D.; Teng, S.; Bhansali, D.; de Amorim Ferreira, M.; Tonello, R.; Peach, C. J.; Latorre, R.; Thanigai, G. S.; Leong, K. W.; Jensen, D. D.
10.1101/2025.03.17.643743 — neuroscience — Posted on 2025-03-17
2231 Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation
Chung, A.; Alipio, J. B.; Ghosh, M.; Evans, L.; Miller, S.; Goode, T. D.; Mehta, I.; Ahmed, O. J.; Sahay, A.
10.1101/2025.03.17.643806 — neuroscience — Posted on 2025-03-17
2233 Complementary roles for hippocampus and anterior cingulate in composing continuous choice
Fine, J. M.; Chericoni, A.; Delgado, G.; Franch, M.; Mickiewicz, E.; Chavez, A. G.; Bartoli, E.; Paulo, D.; Provenza, N.; Watrous, A.; Yoo, S. B. M.; Sheth, S.; Hayden, B. Y.
10.1101/2025.03.17.643774 — neuroscience — Posted on 2025-03-17
2234 Single-cell Spatial Transcriptomics Reveals Disease-specificMicroenvironmental Niches in Neurodegeneration and COVID-19
Graf, S.; Ludwig, N.; Flotho, M.; Engel, A.; Diks, I. F.; Zimmer, P.; Juergens-Wemheuer, W.; Wrede, A.; Mirzac, D.; Gonzalez-Escamilla, G.; Wagner, V.; Menon, V.; Groppa, S.; De Jager, P.; Yiwei, L.; Esteban, M.; Schulz-Schaeffer, W.; Keller, A.
10.1101/2025.03.15.643484 — neuroscience — Posted on 2025-03-17
2235 Transcranial electrical stimulation for memory enhancement: A systematic review and meta-analysis
Goto, Y.; Onagawa, R.; Takemi, M.; Ishikawa, K.; Narukawa, S.; Amano, K.; Hosomi, K.
10.1101/2025.03.17.643623 — neuroscience — Posted on 2025-03-17
2236 Proteomic Analysis of Endemic Viral Infections in Neuronsoffers Insights into Neurodegenerative Diseases
Li, Z.; Martin, N. P.; Epstein, J.; Chen, S.-H.; Hao, Y.; Ramos, D. M.; Andersh, K. M.; Jarreau, P.; Weller, C.; Nalls, M. A.; Pantazis, C. B.; Ferrucci, L.; Cookson, M. R.; Singleton, A. B.; Qi, Y. A.; Yakel, J. L.
10.1101/2025.03.17.643709 — neuroscience — Posted on 2025-03-17
2239 Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast
Sottnik, J. L.; Shackleford, M. T.; Nesiba, C. S.; Richer, A. L.; Fleischmann, Z.; Swartz, J. M.; Rowland, C. E.; Musick, M.; Fu, R.; Myler, L. R.; Opresko, P. L.; Mehrotra, S.; Sokol, E. S.; Hesselberth, J. R.; Diamond, J. R.; Sikora, M. J.
10.1101/2023.10.29.564555 — cancer biology — Posted on 2025-03-17
2240 Podoplanin-Linked Mesenchymal Shift Synergizes with CCR7 driving Lymphatic Metastasis and Tumor Progression in Breast Cancer
Ingebriktsen, L. M.; Wang, Z.; Bekkhus, T.; Bazioti, A.; Zhi, W.; Lehrstrand, J.; Panagias, M. A.; Vigorelli, M.; Ma, L.; Ring, S.; Hoivik, E.; Wik, E.; Fuxe, J.; Ulvmar, M. H.
10.1101/2025.03.17.643704 — cancer biology — Posted on 2025-03-17
2241 Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma
Alhomoud, M.; Foley, M.; Sugita, M.; Fein, J. A.; Yamshon, S.; Martinez, L.; Rejeski, K.; Astorkia, M.; Betel, D.; Brentjens, R.; van Besien, K.; Galluzzi, L.; Boyer, O.; Martinet, J.; Formenti, S.; Guzman, M. L.
10.1101/2025.03.17.643462 — cancer biology — Posted on 2025-03-17
2242 Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice
Li, H.; Aguilar, L.; Shahi, S.; Zhang, Z.; Wen, W.; Hu, D.; Lin, H.; Mangalam, A.; Luo, J.
10.1101/2025.03.17.643801 — cancer biology — Posted on 2025-03-17
2258 Protein dynamics affect O2-stability of Group B -hydrogenase from Thermosediminibacter oceani
Ghosh, S.; Das, C. K.; Uddin, S.; Stripp, S. T.; Engelbrechta, V.; Winkler, M.; Leimkuehler, S.; Duan, J.; Schaefer, L.; Happe, T.
10.1101/2025.03.17.643706 — biochemistry — Posted on 2025-03-17
2259 The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover
Wu, C. C.; Naarmann-de Vries, I. S.; Hartmann, J.; Nidoieva, Z.; Kopietz, K.; Marchand, V.; Özrendeci, Z.; Lindner, D.; Schelchshorn, S.; Flad, S.; Frye, M.; Papavasiliou, N.; Schirmeister, T.; Stoecklin, G.; Schott, J.; Motorin, Y.; Tuorto, F.; Dieterich, C.; Helm, M.; Ruggieri, A.
10.1101/2025.03.17.643699 — biochemistry — Posted on 2025-03-17
2260 Individual dietary amino acid restrictions induce distinct metabolic and chromatin states
Haws, S.; Liu, Y.; Green, C.; Chaiyakul, K.; Mishra, P.; Babygirija, R.; Armstrong, E.; Mehendale, A.; Ong, I. M.; Lamming, D.; Denu, J. M.
10.1101/2023.12.06.570456 — biochemistry — Posted on 2025-03-17
2261 Temporally Resolved and Interpretable Machine Learning Model of GPCR Conformational Transition
Manookian, B.; Mukhaleva, E.; Gogoshin, G.; Bhattacharya, S.; Sivaramakrishnan, S.; Vaidehi, N.; Rodin, A. S.; Branciamore, S.
10.1101/2025.03.17.643765 — biochemistry — Posted on 2025-03-17
2267 Genetic diversity and regulatory features of human-specific NOTCH2NL duplications
Real, T. D.; Hebbar, P.; Yoo, D.; Antonacci, F.; Pacar, I.; Diekhans, M.; Mikol, G. J.; Popoola, O. G.; Mallory, B.; Vollger, M. R.; Dishuck, P. C.; Guitart, X.; Rozanski, A. N.; Munson, K. M.; Hoekzema, K.; Ranchalis, J. E.; Neph, S. J.; Sedeno-Cortes, A. E.; Paten, B.; Salama, S.; Stergachis, A.; Eichler, E. E.
10.1101/2025.03.14.643395 — genomics — Posted on 2025-03-17
2269 Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression
Melton, R.; Jimenez, S.; Elison, W.; Tucciarone, L.; Howell, A.; Wang, G.; Berti, D.; Beebe, E.; Miller, M.; Zeng, C.; Vanderstel, K.; Korgaonkar, K.; Elgamal, R.; Mummey, H.; Chiou, J.; Griffin, E.; Kusmartseva, I.; Atkinson, M. A.; Preissl, S.; Theis, F.; Sander, M.; Gaulton, K. J.
10.1101/2025.02.13.637721 — genomics — Posted on 2025-03-17
2270 Role of lncRNAs related to NRs in the regulation of gene expression
Pierouli, K.; Papageorgiou, L.; Chrousos, G. P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2025.03.17.643776 — genetics — Posted on 2025-03-17
2272 The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans
Feng, X.; Yin, Q.; Gao, F.; Lu, D.; Fang, Q.; Feng, Y.; Huang, X.; Tan, C.; Zhou, H.; Li, Q.; Zhang, C.; Stringer, C.; Ni, X.
10.1101/2024.05.16.594603 — evolutionary biology — Posted on 2025-03-17
2275 Role of individual and population heterogeneity in shaping dynamics of multi-pathogen shedding in an island endemic bat
Aguillon, S.; Turpin, M.; Le Minter, G.; Lebarbenchon, C.; Hoarau, A. O. G.; Toty, C.; Duchet, A.; Joffrin, L.; Ramanantsalama, R. V.; Tortosa, P.; Mavingui, P.; Dietrich, M.
10.1101/2024.06.25.600581 — evolutionary biology — Posted on 2025-03-17
2283 The SMC Hinge is a Selective Gate for Obstacle Bypass
Liu, H. W.; Roisne-Hamelin, F.; Taschner, M.; Collier, J.; Srinivasan, M.; Gruber, S.
10.1101/2025.03.17.643644 — molecular biology — Posted on 2025-03-17
2284 Eicosapentaenoic Acid (EPA) Alleviates LPS-Induced Oxidative Stress via the PPARa-NF-kB Axis
Alabduljader, H.; alsaeed, H.; Alrabeea, A.; Sulaiman, A.; Haider, M.; Al-Mulla, F.; Ahmad, R.; Al-rashed, F.
10.1101/2025.03.17.643636 — molecular biology — Posted on 2025-03-17
2285 Targeted control of gene expression using CRISPR-associated endoribonucleases
Parikh, S. J.; Terron, H. M.; Burgard, L. A.; Maranan, D. S.; Butler, D. D.; Wiseman, A.; LaFerla, F. M.; Lane, S.; Leissring, M. A.
10.1101/2025.03.17.643761 — molecular biology — Posted on 2025-03-17
2286 The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress
Donaldson, A.; Dong, Q.; Day, M.; Saito, Y.; Parker, E.; Watts, L.; Kanemaki, M.; Oliver, A.; Pearl, L. H.; Hiraga, S.-i. H.
10.1101/2025.03.17.643278 — molecular biology — Posted on 2025-03-17
2289 Microbial signatures define the ecosystem functions of the pelagic microbiome in a basin-scale, Southwest Atlantic Ocean
Bergo, N. M.; Peres, F. V.; Vieira, D. C.; Mondolon, F.; Moreira, J. C. F.; Lizarraga, R. G. M.; Bendia, A. G.; Lemos, L. N.; Emilio, A. d. M.; Amendola, A. M.; Castano, D. C. D.; Chuqui, M. G.; Paula, F. d. S.; Romano, R. G.; Brandao, W. W. S. G.; Fonseca, G.; Moreira, D.; Jonck, C. R.; Brandini, F. P.; Pellizari, V. H.
10.1101/2025.03.17.643744 — microbiology — Posted on 2025-03-17
2290 A multiplexed, target-based phenotypic screening platform using CRISPR interference in Mycobacterium abscessus
Neo, D. M.; Ben-Zion, I.; Bagnall, J.; Solomon, M.; Bond, A. N.; Gath, E.; Zhang, S.; Shoresh, N.; Gomez, J. E.; Hung, D. T.
10.1101/2025.03.17.643728 — microbiology — Posted on 2025-03-17
2292 Ultra long-lived plasma cells in the human small intestine produce microbiota-reactive IgA antibodies
Pati, N. B.; Chung, B. K.; Holm, K.; Saetre, F.; Reims, H. M.; Aasebo, A. T.; Gedde-Dahl, T.; Domanska, D.; Hov, J. R.; Baekkevold, E. S.; Jahnsen, F. L.
10.1101/2025.03.17.643697 — immunology — Posted on 2025-03-17
2293 Flagellin aerosol administration improves the efficacy of antibiotic treatment in Actinobacillus pleuropneumoniae infected pigs
Fleurot, I.; Guillory, V.; Barc, C.; Riou, M.; Deslis, A.; Pleau, A.; Larcher, T.; Baldry, M.; Trapp, S.; Stockhofe, N.; Ruuls, L.; van Solt, C.; Sirard, J.-C.; Caballero, I.
10.1101/2025.03.17.643685 — immunology — Posted on 2025-03-17
2294 Therapeutic CD8+T cell tissue retention and immunomodulation during ART interruption fails to prevent SIV rebound
Pampena, M. B.; Samer, S.; Viox, E. G.; Nguyen, K.; Deleage, C.; Kuri-Cervantes, L.; Regan, J. M.; Wu, V. H.; Docken, S.; Safrit, J. T.; Bar, K. J.; Keele, B. F.; Davenport, M. P.; Paiardini, M.; Betts, M. R.
10.1101/2025.03.17.643755 — immunology — Posted on 2025-03-17
2295 Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19
Lira-Junior, R.; Ambikan, A.; Cederholm, A.; Rezene, S.; Mikaeloff, F.; Akusjarvi, S. S.; Yalcinkaya, A.; Chen, X.; Sperk, M.; Guillen, M. A.; Nordqvist, H.; Treutiger, C. J.; Landegren, N.; Neogi, U.; Gupta, S.
10.1101/2025.03.14.643374 — immunology — Posted on 2025-03-17
2296 LILRA5 functions to induce ROS production on innate immune cells
Fu, Z.; Rumpret, M.; Kube-Golovin, I.; Lyndin, M.; Solntceva, V.; Zhao, Y.; Konieva, A.; Liu, N.; Press, A.; Flohe, S.; Bauer, M.; Wennemuth, G.; Singer, B. B.; McCarthy, A. J.
10.1101/2025.03.16.643524 — immunology — Posted on 2025-03-17
2299 Caffeine induces age-dependent increases in brain complexity and criticality during sleep
Thölke, P.; Arcand-Lavigne, M.; Lajnef, T.; Frenette, S.; Carrier, J.; Jerbi, K.
10.1101/2024.05.27.596056 — neuroscience — Posted on 2025-03-17
2303 SYSTEM XC- AS A MOLECULAR MECHANISM FOR EVOLUTIONARY NEW FORMS OF ADVANCED COGNITION
Simandl, G.; Twining, R. C.; Raddatz, N. J.; Berentson, G.; Peck, S.; Wheeler, R.; Savtchouk, I.; Choi, S.; Baker, D. A.
10.1101/2025.03.17.643792 — neuroscience — Posted on 2025-03-17
2304 Transcriptional Profiles in Nucleus Accumbens of Antidepressant Resistance in Chronically Stressed Mice
Gyles, T.; Parise, E.; Estill, M.; Browne, C. J.; Shen, L.; Nestler, E. J.; Torres-Berrio, A.
10.1101/2025.03.17.643727 — neuroscience — Posted on 2025-03-17
2305 Mapping energy metabolism systems in the human brain
Pourmajidian, M.; Hansen, J. Y.; Shafiei, G.; Misic, B.; Dagher, A.
10.1101/2025.03.17.643763 — neuroscience — Posted on 2025-03-17
2306 Role of CaMKIIa reticular neurons of caudal medulla in control of posture
Zelenin, P.; Lyalka, V. F.; Chang, S.-H.; Lallemend, F.; Deliagina, T. G.; Hsu, L.-J.
10.1101/2025.03.17.643745 — neuroscience — Posted on 2025-03-17
2307 PACAP Signaling Network in the Nucleus Accumbens Core Regulates Reinstatement Behavior in Rat
Bose, S.; Simandl, G.; Hess, E. M.; Kong, L.; Raddatz, N. J.; Maunze, B.; Choi, S.; Baker, D.
10.1101/2025.03.17.643720 — neuroscience — Posted on 2025-03-17
2309 Eye movements anticipate target rebounds in an interception task
Villegas, M. T.; Martin, N. V.; Torres, F. J. H.; Gonzalez, A. G. B.; Noriego, I. M.
10.1101/2025.03.17.643715 — neuroscience — Posted on 2025-03-17
2310 FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes
Adamczyk, N. S.; Ishihara, S.; Obeidat, A. M.; Ren, D.; Miller, R. J.; Malfait, A.-M.; Miller, R. E.
10.1101/2025.03.17.643683 — neuroscience — Posted on 2025-03-17
2311 Chemical targeting of the ATXN1 aa99-163 interaction site suppresses polyQ-expanded protein dimerization
Gkekas, I.; Pliatsika, K.; Mylonas, S.; Katsamakas, S.; Axenopoulos, A.; Kostova, S.; Wanker, E. E.; Hadjipavlou-Litina, D.; Xanthopoulos, K.; Daras, P.; Petrakis, S.
10.1101/2025.03.17.643445 — neuroscience — Posted on 2025-03-17
2312 Intracortical transplantation of human induced pluripotent stem cell-derived progenitors ameliorates delayed thalamic degeneration following cortical stroke
Kartsivadze, S.; Jansson, L.; Galan-Pintado, L.; Kher, K.; Aviles, S.; Martinez-Curiel, R.; Tortosa, S. P.; Lindvall, O.; Kokaia, Z.
10.1101/2025.03.17.643730 — neuroscience — Posted on 2025-03-17
2314 AvianLexiconAtlas: A database of descriptive categories of English-language bird names around the world
Morrison, E. S.; Pandolfi, G. P.; Aguillon, S. M.; Ali, J. R.; Archard, O.; Baldassarre, D. T.; Baquero, I.; Bennett, K. F. P.; Bonney, K. M.; Bryant, R.; Catanach, R. M.; Catanach, T. A.; Chavoshan, I.; Davis, S. N.; Goodman, B. D.; Gulson-Castillo, E. R.; Hack, M.; Hudon, J.; Leighton, G. M.; Long, K. M.; Ma, Z.; McCoy, D. E.; McLaughlin, J. F.; Rueda Moreno, G.; Mota, T. M.; Noguchi, L.; Nwigwe, U.; Pegan, T.; Provost, K.; Rasband, S. A.; Salter, J. F.; Silvernail, L. C.; Simard, J. A.; Skeen, H. R.; Soto-Patino, J.; Suh, Y. H.; Wang, Q.; Warshauer, M. E.; Yan, S.; Zalinski, B.; Zhao, Z.; S
10.1101/2024.09.13.612884 — zoology — Posted on 2025-03-17
2315 Manipulation of in planta ethylene levels modulates the metabolome of Populus tremula x tremuloides in a microbial-dependent manner.
Fracchia, F.; Guinet, F.; Warion, S.; Bednareck, M.; Chervin, C.; Engle, N. L.; Tschaplinski, T. J.; Veneault-Fourrey, C.; Deveau, A.
10.1101/2025.03.17.643694 — plant biology — Posted on 2025-03-17
2317 Loss of PIF7 attenuates shade and elevated temperature responses throughout the lifecycle in Pennycress
Jawahir, V.; Griffiths, M.; Adam, S.; Borphukan, B.; Sanguinet, K. A.; Phippen, W.; Wesley, T.; Heller, N.; Nusinow, D. A.
10.1101/2025.03.17.643809 — plant biology — Posted on 2025-03-17
2319 Quantification of collagen and associated features from H&E-stained whole slide pathology images across cancer types using a physics-based deep learning model
Nguyen, T. H.; Zhang, J.; Hipp, J.; Chhor, G.; Griffin, M.; Le, N.; Kartik, D.; Zhang, Y.; Mirzadeh, M.; Varao, J.; Allay, J.; Sweeney, M.; Rivera, V.; Johnson, B.; Brosnan-Cashman, J. A.; Bronnimann, M.; Pokkalla, H.; Glass, B.; Beck, A. H.; Lee, J.; Egger, R.
10.1101/2025.03.17.643273 — pathology — Posted on 2025-03-17
2320 IL-1R1 Blockade Enhances CD40 Agonist-Mediated Immune Responses but Fails to Increase Efficacy or Mitigate Hepatotoxicity in Pancreatic Cancer
Boda, A.; Bandey, I. N.; CHOWDHURY, S.; Aggarwal, S.; Reddy, M. v.; Fowlkes, N. W.; Roszik, J.; Curran, M. A.; Morris, V. K.; Kopetz, S.; Singh, M.
10.1101/2025.02.23.639774 — cancer biology — Posted on 2025-03-17
2321 Ex vivo massively multidimensional diffusion-relaxation correlation MRI: scan-rescan reproducibility and caveats
Or, P. S. K.; Yon, M.; Narvaez, O.; Manninen, E.; Malm, T.; Sierra, A.; Topgaard, D.; Benjamini, D.
10.1101/2025.03.17.643705 — biophysics — Posted on 2025-03-17
2323 Comet fragment-ion indexing for enhanced peptide sequencing
McGann, C. D.; Bergstrom, E. J.; Sharma, V.; Heil, L. R.; Yu, Q.; Eng, J. K.; Schweppe, D. K.
10.1101/2024.10.11.617953 — bioinformatics — Posted on 2025-03-17
2325 The non-catalytic ϵ DNA polymerase subunit is an NPF motif recognition protein
Keskitalo, S.; Zambo, B.; Tuhkala, A.; Salokas, K.; Turunen, T.; Deutsch, N.; Davey, N.; Dosztanyi, Z.; Varjosalo, M.; Gogl, G.
10.1101/2025.03.17.643635 — biochemistry — Posted on 2025-03-17
2328 Immune-Coagulation Dynamics in Severe COVID-19: Insights from Autoantibody Profiling and Transcriptomics
Ambikan, A.; Cederholm, A.; Rezene, S.; Guillen, M. A.; Nordqvist, H.; Treutiger, C. J.; Lira-Junior, R.; Landegren, N.; Gupta, S.
10.1101/2025.03.14.643398 — immunology — Posted on 2025-03-17
2329 Overcoming sensory-memory interference in working memory circuits
Zahorodnii, A.; Mendoza-Halliday, D.; Martinez-Trujillo, J. C.; Qian, N.; Desimone, R.; Cueva, C. J.
10.1101/2025.03.17.643652 — neuroscience — Posted on 2025-03-17
2330 Galectin-3 deletion modulates microglial phenotype and Aβ response via TREM2 activation while attenuating neuroinflammation
Camprubi-Ferrer, L.; Soldan-Hidalgo, J.; Axell, E.; Garcia-Cruzado, M.; Yang, Y.; Fernandez-Calle, R.; Larlham, L.; Chouhan, B.; Garcia-Revilla, J.; Talaveron, R.; Paulus, A.; Danielson, L.; Gomez-Arboledas, A.; Klementieva, O.; Gutierrez, A.; Vitorica, J.; Boza-Serrano, A.; Frontinan, J.; Venero, J. L.; Deierborg, T.
10.1101/2025.03.17.643790 — neuroscience — Posted on 2025-03-17
2331 Disrupted bone microenvironment and immune recovery following total body irradiation in a murine model
Saghy, T.; Gupta, P.; Horkeby, K.; Hening, P.; Ohlsson, C.; Corciulo, C.; Lagerquist, M. K.; Chagin, A. S.; Engdahl, C.
10.1101/2025.03.17.643638 — molecular biology — Posted on 2025-03-17
2332 Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene by AAV9 obviates lipid phenotypes in brain and plasma of zQ175DN HD mice
Iwanowicz, A.; Boudi, A.; Seeley, C.; Sapp, E.; Miller, R.; Liu, S.; Chase, K.; Shing, K.; Batista, A. R.; Siena-Esteves, M.; Aronin, N.; Difiglia, M.; Kegel-Gleason, K. B.
10.1101/2025.01.06.630918 — neuroscience — Posted on 2025-03-17
2333 Systematic Discovery and Design of Synthetic Immune Receptors in Plants
Ngou, B. P. M.; Wyler, M.; Schmid, M. W.; Suzuki, T.; Dohmae, N.; Kadota, Y.; Shirasu, K.
10.1101/2025.03.17.642524 — plant biology — Posted on 2025-03-17
2334 Chronic obesity does not alter cancer incidence in Tp53R270H/+ mice
Panzeri, I.; Madaj, Z.; Fagnocchi, L.; Apostle, S.; Tompkins, M.; Hostetter, G.; Pospisilik, J. A.
10.1101/2024.10.14.618190 — cancer biology — Posted on 2025-03-17
2336 Density-Dependent Cell Migration in the Absence of Social Interactions: A Case Study of Acanthamoeba castellanii
Ghazi, N.; Demircigil, M.; Cochet-Escartin, O.; Chauviat, A.; Favre-Bonte, S.; Anjard, C.; RIEU, J.-P.
10.1101/2025.03.16.643508 — biophysics — Posted on 2025-03-17
2337 Lumen charge governs memristive ion transport in β-barrel nanopores
Mayer, S. F.; Mitsioni, M.; van den Heuvel, L.; Robin, P.; Ronceray, N.; Marcaida, M. J.; Abriata, L. A.; Krapp, L. F.; Anton, J. S.; Soussou, S.; Jeanneret-Grosjean, J.; Fulciniti, A.; Moller, A.; Vacle, S.; Feletti, L.; Brinkerhoff, H.; Laszlo, A. H.; Gundlach, J. H.; Emmerich, T.; Dal Peraro, M.; Radenovic, A.
10.1101/2024.09.26.615172 — biophysics — Posted on 2025-03-17
2344 Single-cell transcriptomic atlas of human retina from Chinese donors reveals population-specific cellular diversity
LIN, S.; TAO, Y.; Yang, L.; Pan, Q.; CAI, T.; Ye, Y.; Liu, J.; Zhou, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Shao, Y.; Meng, W.
10.1101/2025.03.16.643491 — genomics — Posted on 2025-03-17
2345 Genome-wide ribonucleotide detection in Archaea
Moalic, Y.; Reveil, M.; Kundnani, D. L.; Balachander, S.; Yang, T.; Gombolay, A.; Ranjbarian, F.; Durand, P.; Myllykallio, H.; Jebbar, M.; Storici, F.; Henneke, G.
10.1101/2025.03.17.643674 — genomics — Posted on 2025-03-17
2346 In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component
Valdivia-Francia, F.; Ghoshdastider, U.; Renz, P. F.; Spies, D.; Ormiston, M.; Hyams, K.; Shi, C.; Dure, C.; Yigit, M.; Taborsky, D.; Khandekar, A.; Weber, R.; Yamahachi, H.; Ellis, S. J.; Sendoel, A.
10.1101/2025.03.17.643322 — genetics — Posted on 2025-03-17
2348 A contribution to the anatomy of two rare cetacean species: the hourglass dolphin (Lagenorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica)
Graic, J.-M.; Gerussi, T.; Cozzi, B.; Boys, R. M.; Kot, B. C. W.; Perrott, M.; Fleury, K.; Chung, T. Y. T.; Tsui, H. C. L.; Burns, E.; Webster, T.; Hunter, S.; Betty, E.; Howarth, O.; Loch, C.; White, S.; Dawson, S.; Rayment, W.; Cole, R.; Cox, D.; Waterhouse, T.; Hendriks, H.; van Helden, A.; Johnstone, M.; Stewart, R. O.; Fordyce, R. E.; Stockin, K. A.
10.1101/2024.11.06.622215 — evolutionary biology — Posted on 2025-03-17
2354 Characterisation of the Avascular Mesenchyme during Digit Outgrowth
Batho-Samblas, C. C.; Smith, J.; Keavey, L.; Clancy, N.; McTeir, L.; Davey, M. G.
10.1101/2025.03.17.643637 — developmental biology — Posted on 2025-03-17
2355 Human jejunal enteroids for studies of epithelial drug transport and metabolism
Ceylan, M.; Tzioufa, F.; Di Martino, M. L.; Hammar, R.; Lopes, A.; Eriksson, J.; Vo, D. S.; Sundbom, M.; Skoger, M.; Hellstrom, P.; Webb, D.-L.; Karlgren, M.; Gardner, I.; Lundquist, P.; Hjelmqvist, D.; Sellin, M. E.; Hubert, M.; Artursson, P.
10.1101/2025.03.17.643545 — cell biology — Posted on 2025-03-17
2356 Mechanisms of Activation and Serotonin release from Human Enterochromaffin Cells
Alcaino, C.; Guccio, N.; Miedzybrodzka, E. L.; Quale, J. R.; Davison, A.; Smith, C. A.; Overington, E.; Santos-Hernandez, M.; Tabbada, M.; Lu, T.; Hodge, M.; Bany-Bakar, R.; Kay, R. G.; Shaaban, A.; Imig, C.; Reimann, F.; Gribble, F. M.
10.1101/2025.03.17.643631 — cell biology — Posted on 2025-03-17
2359 Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes
Ramadoss, G. N.; Namaganda, S. J.; Hamilton, J. R.; Sharma, R.; Chow, K. G.; Macklin, B. L.; Sun, M.; Liu, J.-C.; Fellmann, C.; Watry, H. L.; Jin, J.; Perez, B. S.; Sandoval Espinoza, C. R.; Matia, M. P.; Lu, S. H.; Judge, L. M.; Nussenzweig, A.; Adamson, B.; Murthy, N.; Doudna, J. A.; Kampmann, M.; Conklin, B. R.
10.1101/2024.06.25.600517 — molecular biology — Posted on 2025-03-17
2361 High-Throughput Epigenetic Profiling Immunoassays for Accelerated Disease Research and Clinical Development
Van den Ackerveken, P.; Hannart, C.; Pamart, D.; Varsebroucq, R.; Wargnies, M.; Thiry, O.; Lurkin, M.; Vincent, S.; Chapelier, M.; Rommelaere, G.; Herzog, M.
10.1101/2024.12.05.626944 — molecular biology — Posted on 2025-03-17
2362 LongTrack: long read metagenomics-based precise tracking of bacterial strains and their genomic changes after fecal microbiota transplantation
Fan, Y.; Ni, M.; Aggarwala, V.; Mead, E. A.; Ksiezarek, M.; Cao, L.; Kamm, M. A.; Borody, T.; Paramsothy, S.; Kaakoush, N. O.; Grinspan, A.; Faith, J. J.; Fang, G.
10.1101/2024.09.30.615906 — microbiology — Posted on 2025-03-17
2363 Type IV pili-associated secretion of a biofilm matrix protein from Clostridium perfringens that forms intermolecular isopeptide bonds
Kivimaki, S. E.; Dempsey, S.; Tani, J. M.; Camper, C.; Hicklin, I. K.; Blaby-Haas, C. E.; Brown, A. M.; Melville, S.
10.1101/2024.11.04.621531 — microbiology — Posted on 2025-03-17
2364 Comparing Raman and NanoSIMS for heavy water labeling of single cells
Schaible, G.; Cliff, J.; Crandall, J.; Bougoure, J.; Mathuri, M. N.; Sessions, A. L.; Atwood, J.; Hatzenpichler, R.
10.1101/2024.07.05.602271 — microbiology — Posted on 2025-03-17
2374 Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway
Barry, A. M.; Sondermann, J. R.; Lesnak, J. B.; Xian, F.; Franco-Enzastiga, U.; O'Brien, J. A.; Varela, D. G.; Schackmuth, M. K.; Shiers, S.; Price, T. J.; Schmidt, M.
10.1101/2024.12.06.626968 — neuroscience — Posted on 2025-03-17
2376 Machine Learning-based Identification and Characterization of High-risk Carriers of HTLV-1-Associated Myelopathy (HAM)
Rashid, I. M.; Sunagawa, J.; Matsuki, A.; Watanabe, T.; Iwanaga, M.; Koh, K.-R.; Yamada, A.; Shichijo, T.; Matsuoka, M.; Yasunaga, J.-i.; Nakaoka, S.
10.1101/2025.03.17.643639 — systems biology — Posted on 2025-03-17
2377 EVOFLOW-RNA: GENERATING AND REPRESENTING NON-CODING RNA WITH A LANGUAGE MODEL
Patel, S.; Peng, F. Z.; Fraser, K.; Friedman, A. D.; Chatterjee, P.; Yao, S.
10.1101/2025.02.25.639942 — synthetic biology — Posted on 2025-03-17
2379 Non-invasive assessment of integrated cardiorespiratory network dynamics after physiological stress in humans
Morandotti, C.; Rigny, L.; Williams, T. B.; Badariotti, J. I.; Miller-Dicks, M.; Bhogal, A. S.; Han, S.; Corbett, J.; Tipton, M. J.; Costello, J. T.; Mani, A.
10.1101/2025.03.17.643643 — physiology — Posted on 2025-03-17
2380 Manganese suppresses tumor growth through hyper-activating IRE1α
Shi, R.; Wang, M.; Chen, S.; Hu, X.; Zhao, X.; Zhou, S.; Fan, C.; Zhou, Z.; Wang, L.
10.1101/2025.03.16.643497 — cancer biology — Posted on 2025-03-17
2382 High-Throughput Mechanomic Screening Reveals Novel Regulators of Single-Cell Mechanics
Strampe, L.; Plak, K.; Schweitzer, C.; Liebers, C.; Müller, P.; Baum, B.; Kayser, J.; Guck, J.
10.1101/2025.03.16.643502 — biophysics — Posted on 2025-03-17
2383 Transport kinetics across interfaces between coexisting liquid phases
Hubatsch, L.; Bo, S.; Harmon, T. S.; Hyman, A. A.; Weber, C. A.; Julicher, F.
10.1101/2024.12.20.629798 — biophysics — Posted on 2025-03-17
2385 A Novel Algorithm for the Harmonization of Pan-cancer Proteomics
Simchi, N.; Givton, O.; Rinberg, J.; Shtrikman, A.; Geiger, T.; Nesvizhskii, A. I.; Seger, E.; Pevzner, K.
10.1101/2025.03.17.642820 — bioinformatics — Posted on 2025-03-17
2386 High-efficiency likelihood inference of shared proteomic architectures across 50 complex human traits
Sun, X.; Yang, S.; Peng, Q.; Zhang, X.; Qian, Y.; Sun, R.; Zhang, G.; Wang, S.; Jin, L.; Zhang, M.
10.1101/2025.03.16.643065 — bioinformatics — Posted on 2025-03-17
2392 Whole-genome sequence of Potamopyrgus antipodarum: a model system for the maintenance of sexual reproduction reveals a recent whole-genome duplication
Jalinsky, J. R.; McElroy, K. E.; Sharbrough, J.; Bankers, L.; Fields, P.; Higgins, C.; Toll, C.; Boore, J.; Logsdon, J. M.; Neiman, M.
10.1101/2025.03.16.643514 — genomics — Posted on 2025-03-17
2395 Haplotype Bias Detection Using Pedigree-Based Transmission Simulation: Traces of Selection That Occurred in Apple Breeding
Mochizuki, H.; Minamikawa, M. F.; Hamazaki, K.; Kunihisa, M.; Moriya, S.; Noshita, K.; Hayashi, T.; Katayose, Y.; Yamamoto, T.; Iwata, H.
10.1101/2025.03.16.643583 — genetics — Posted on 2025-03-17
2398 Proto-MHC signatures in the lamprey genome
Sutoh, Y.; Ono, K.; Minabe, S.; Senanayake, S.; Ohmomo, H.; Hachiya, T.; Shimizu, A.; Hirano, M.
10.1101/2025.03.16.643586 — evolutionary biology — Posted on 2025-03-17
2402 Climate change favours African malaria vector mosquitoes
van der Deure, T.; Nogues-Bravo, D.; Njotto, L. L.; Stensgaard, A.-S.
10.1101/2025.03.17.643604 — ecology — Posted on 2025-03-17
2405 Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity
Marques, A.-S. M. C.; Bauer, L. G.; Nguyen, T.-A.; Orta, A. G.; Venne, J.-L.; Cheng, C.; Balikci, E.; Tivon, B.; London, N.; Kubicek, S.; Huber, K. V. M.
10.1101/2025.03.16.643557 — cell biology — Posted on 2025-03-17
2409 Uncovering functional deterioration in the rhizosphere microbiome associated with wheat dwarfing
Smith, M. E.; Kavamura, V. N.; Hughes, D.; Mendes, R.; Clark, I.; Mauchline, T.; Lund, G. A.
10.1101/2025.03.16.643510 — microbiology — Posted on 2025-03-17
2410 Joint bacterial traces in the gut and oral cavity of Colitis patients provide evidence for saliva as rich microbial biomarker source
Rehner, J.; Gund, M. P.; Becker, S. L.; Hannig, M.; Rupf, S.; Schattenberg, J. M.; IMAGINE consortium, PharmaScienceHub, Saarbruecken, ; Keller, V.
10.1101/2025.03.17.643500 — microbiology — Posted on 2025-03-17
2412 Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1
Gregg, B.; Guerra, A. J.; Raverty, S. A.; Sardinha-Silva, A.; Kafsack, B. F. C.; Schultz, T. L.; Gurczynski, S. J.; Moore, B. B.; Carruthers, V. B.; Grigg, M. E.
10.1101/2025.03.17.643671 — microbiology — Posted on 2025-03-17
2414 Amyloid beta is released by lysosomal exocytosis from hiPSC-derived neurons
Tsang, A. R.; Medapati, M. R.; Seah, C.; Krupa, J. M.; Pasternak, S. H.
10.1101/2025.03.01.640950 — neuroscience — Posted on 2025-03-17
2415 Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood
Bulgarelli, C.; Blasi, A.; McCann, S.; Milosavljevic, B.; Ghillia, G.; Mbye, E.; Touray, E.; Fadera, T.; Acolatse, L.; Moore, S. E.; Lloyd-Fox, S.; Elwell, C. E.; Eggebrecht, A. T.
10.1101/2024.01.02.573930 — neuroscience — Posted on 2025-03-17
2416 Genetic Foundations of Inter-individual Neurophysiological Variability
da Silva Castanheira, J.; Poli, J.; Hansen, J. Y.; Misic, B.; Baillet, S.
10.1101/2024.07.19.604292 — neuroscience — Posted on 2025-03-17
2417 Fast in vivo deep-tissue 3D imaging with selective-illumination NIR-II light-field microscopy and aberration-corrected implicit neural representation
Fei, P.; Zhong, F.; Li, X.; He, M.; Huang, Y.; Yi, C.; Mao, S.; Huang, X.; Ren, K.; Kang, M.; Wang, D.; Zhang, Z.; Li, D.
10.1101/2025.03.16.643569 — neuroscience — Posted on 2025-03-17
2419 Sensory prediction errors predict motor prediction errors
Tran, D. M. D.; McNair, N. A.; Whitton, A. E.; Whitford, T. J.; Livesey, E. J.
10.1101/2025.03.16.643175 — neuroscience — Posted on 2025-03-17
2420 Mapping Brain Growth and Sex Differences Across Prenatal to Postnatal Development
Khan, Y. T.; Tsompanidis, A.; Radecki, M. A.; Allison, C.; Lai, M.-C.; Bethlehem, R. A. I.; Baron-Cohen, S.
10.1101/2025.03.17.643640 — neuroscience — Posted on 2025-03-17
2421 Non-linear effects of evening light exposure on cognitive performance
Reitmayer, A.; Kobas, B.; Kammermeier, M.; Rivera Luque, C.; Rockcastle, S.; Johnstone, K. R.; Madigan, C.; Cook, M. M.; Auer, T.; Spitschan, M.
10.1101/2025.03.16.643585 — neuroscience — Posted on 2025-03-17
2422 NeoAtlas and NeoBert: A Database and A Predictive Model for Canonical and Noncanonical Tumor Neoantigens
Shi, M.; Yan, Q.; Zhao, W.; Teng, C.; Han, F.; Chen, H.; Li, Y.; Xu, L.; Yang, F.; Jin, G.; Bao, Y.; Zuo, C.; Li, J.
10.1101/2025.03.16.643518 — systems biology — Posted on 2025-03-17
2424 Diurnal Regulation of Urinary Behavior and Gene Expression in Aged Mice
Taylor, D. S.; Allotey, A. A.; Fanelli, R. E.; Satyanarayana, S. B.; Bettadapura, S. S.; Wyatt, C. R.; Nelson, A. C.; Schmitt, E. E.; Bruns, D. R.; Bedford, N. L.
10.1101/2025.03.16.642675 — physiology — Posted on 2025-03-17
2426 LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC
Chakraborty, A. K.; Kroehling, L.; Raut, R.; Choudhury, C.; Kukuruzinska, M.; Gutkind, J. S. V.; Varelas, X.; Sahay, B.; Monti, S.; Bais, M. V.
10.1101/2025.03.17.643710 — cancer biology — Posted on 2025-03-17
2427 Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis
Riggio, A. I.; Sweeney, K.; Shaw, R.; Khan, A.; Lawlor, A.; Ferrari, N.; Gilroy, K.; Bull, C.; Young, A.; Athineos, D.; Hall, H.; Ghaffar, F.; Nixon, C.; Adams, P.; Roberts, E.; Miller, C.; Dunne, P.; Campbell, K.; Cameron, E.; Blyth, K.
10.1101/2025.03.16.643517 — cancer biology — Posted on 2025-03-17
2428 A unifying model for microRNA-guided silencing of messenger RNAs
Chatterjee, T.; Mandal, S.; Ray, S.; Johnson-Buck, A.; Walter, N. G.
10.1101/2025.03.16.643529 — biophysics — Posted on 2025-03-17
2430 Deep contrastive feature compression with classical machine learning enables ligand discovery through efficient triage of large chemical libraries
Rayakar, A. A.; Jaladanki, C. K.; Ong, Q.; Tan, B.; Chen, J.; Tan, A. Q. L.; Lim, L. T. R.; Kohaal, N.; Chen, Y.; Wang, J.; Han, W.; Hu, J.; Lee, H. K.; Fan, H.
10.1101/2025.03.16.643501 — bioinformatics — Posted on 2025-03-17
2432 WITHDRAWN: Genomic and Phenotypic Consequences of Bi-Directional Introgression Between Chinese and European Pig Breeds
Qiu, Y.; Liu, L.; Huang, M.; Ruan, D.; Ding, R.; Zhang, Z.; Zheng, E.; Wang, S.; Deng, S.; Cheng, X.; Shi, J.; Yang, Y.; Zhou, F.; Huang, S.; Yang, H.; Li, Z.; Cai, G.; Yang, J.; Wu, Z.
10.1101/2023.12.21.572727 — genetics — Posted on 2025-03-17
2434 Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci
Rahman, M. M.; Zamakhaeva, S.; Rush, J. S.; Chaton, C. T.; Kenner, C. W.; Hla, Y. M.; Tsui, H.-C. T.; Uversky, V. N.; Winkler, M. E.; Korotkov, K. V.; Korotkova, N.
10.1101/2024.05.05.592596 — microbiology — Posted on 2025-03-17
2435 Genetic risk in endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease
Mamde, S.; Rose, S.; Prater, K. E.; Cochoit, A.; Smith, I.; Johnson, C. S. C.; Strohbehn, S.; Rolf, B.; Lin, K.; Garden, G.; Blue, E.; Young, J. E.; Jayadev, S.
10.1101/2025.03.16.643481 — neuroscience — Posted on 2025-03-17
2436 The Origin, Diagnosis, and Prognosis of Oligomannose-Type Diffuse Large B Cell Lymphoma
Tatterton, D. J.; Newby, M. L.; Allen, J. D.; Sale, B. J.; Chiodin, G.; Duriez, P. J.; Butler, J.; McCann, K. J.; Scott, D. W.; Morin, R. D.; Dreval, K.; Davies, A. J.; Bryant, D. J.; Crispin, M.; Forconi, F.
10.1101/2025.03.11.642396 — cancer biology — Posted on 2025-03-17
2437 Thioredoxin reductase 3 inhibition sensitizes triple-negative breast cancer cells to EGFR inhibitors
Raninga, P. V.; Giner, G.; Sankarasubramanian, S.; Ambalathingal, G.; Kalimutho, M.; Herold, M. J.; Khanna, K. K.
10.1101/2025.03.16.642742 — cancer biology — Posted on 2025-03-17
2439 Hydroxychloroquine-functionalized Ionizable Lipids Mitigate Inflammatory Responses in mRNA Therapeutics
Chen, K.; Li, X.; Feng, S.; Li, Y.; Jiang, T.; Liu, Y.; Guo, N.; Zeng, X.; Yao, H.; Qiu, M.; Lu, J.; Lin, J.
10.1101/2025.03.02.641033 — bioengineering — Posted on 2025-03-17
2445 Synthetic derivatives of vinpocetine as antiproliferative agents
Gutti, M.; Tsui, M.; Yang, S.; Xi, S.; Luo, J.; Desarkar, A.; Xie, Y.; Feng, M.; Avadhani, U.; Raghavan, S.; Brierley-Green, E.; Yu, E.; Njoo, E.
10.1101/2025.03.15.643482 — cancer biology — Posted on 2025-03-17
2447 Designed allosteric biosensors for engineered T cell therapy of cancer
Rath, J. A.; Rudden, L. S.; Nouraee, N.; Que, X.; Von Gunten, C.; Perez, C.; Birch, F.; Bhugowon, Y.; Fueglistaler, A.; Souleiman, A. C.; BARTH, P.; Arber, C.
10.1101/2025.03.14.643388 — bioengineering — Posted on 2025-03-17
2449 Extreme GC3 Codon Bias in a Novel Brown Seaweed Virus Results in Pseudoambigrammatic Characteristics
Dekker, R. J.; de Leeuw, W. C.; Rauwerda, H.; van Olst, M.; Ensink, W. A.; van Leeuwen, S.; Cohen, J.; Timmermans, K. R.; Breit, T. M.; Jonker, M. J.
10.1101/2025.03.14.643323 — genomics — Posted on 2025-03-17
2451 Tracking Coordinated Cellular Dynamics in Time-Lapse Microscopy with ARCOS.px
Grädel, B.; Brönnimann, L.; Gagliardi, P. A.; Hinderling, L.; Pertz, O.; Dobrzynski, M.
10.1101/2025.03.14.643386 — cell biology — Posted on 2025-03-17
2453 Leveraging mRNA platform for the development of vaccines against egg allergy
Shao, X.; Weng, C.; Liu, L.; Guo, K.; Lu, Z.; Huang, L.; Di, Z.; Guo, Y.; Di, G.; Qiao, R.; Wang, J.; Yang, Y.; Sun, S.; Zhuang, S.; Lin, A.
10.1101/2025.03.14.643193 — immunology — Posted on 2025-03-17
2454 CD34 serves as an intrinsic innate immune guardrail protecting stem cells from replicating retroviruses
He, S.; Haikerwal, A.; Tiwari, S.; Dabbagh, D.; Alam, M. Z.; Yoon, J. L.; Hetrick, B.; Han, Y.; Shan, L.; Lockhart, C.; Wu, Y.
10.1101/2025.03.15.643450 — immunology — Posted on 2025-03-17
2455 Imbalance of Tregs/B cells and elevated complement signalling are hallmarks of Refractory Myasthenia Gravis
Dodd, K. C.; Baillie, K.; Holt, J. K.; Leite, M. I.; Miller, J. A.; Spillane, J.; Viegas, S.; Zelek, W.; Sussman, J.; Menon, M.
10.1101/2025.03.15.643341 — immunology — Posted on 2025-03-17
2456 Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver disease
Petrenko, O.; Sorz-Nechay, T.; Bilban, M.; Derdak, S.; Van Melkebeke, L.; Huang, W.; Verbeek, J.; van der Merwe, S.; Hofer, B. S.; Simbrunner, B.; Reiberger, T.; Hendrikx, T.
10.1101/2025.03.15.643421 — systems biology — Posted on 2025-03-17
2457 PWO proteins are associated with PRC2 since their emergence in vascular plants
Khan, A.; Haider, S.; Sharaf, A.; Kusova, A.; Skalak, J.; Jourdain, C.; Rennie, M.; Schrumpfova, P. P.; Hejatko, J.; Schubert, D.; Farrona, S.; Mozgova, I.
10.1101/2025.03.15.643013 — plant biology — Posted on 2025-03-17
2460 A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death
Nix, M. N.; Gourisankar, S.; Sarott, R. C.; Dwyer, B. G.; Nettles, S. A.; Martinez, M. M.; Abuzaid, H.; Yang, H.; Wang, Y.; Simanauskaite, J. M.; Romero, B. A.; Jones, H. M.; Krokhotin, A.; Lowensohn, T. N.; Chen, L.; Low, C.; Davis, M. M.; Fernandez, D.; Zhang, T.; Green, M. R.; Hinshaw, S. M.; Gray, N. S.; Crabtree, G. R.
10.1101/2025.03.14.643404 — cancer biology — Posted on 2025-03-17
2461 Differential Phagocytosis induces Diverse Macrophage Activation States in Malignant Gliomas
Lakshmanachetty, S.; Riemondy, K. A.; Sanford, B.; Donson, A.; Balakrishnan, I.; Prince, E. W.; Dahl, N.; Venkataraman, S.; Vibhakar, R.; Foreman, N.; Mitra, S. S.
10.1101/2025.03.15.642920 — cancer biology — Posted on 2025-03-17
2462 In Vivo Multiplexed Modeling Reveals Diverse Roles of the TBX2 Subfamily and Egr1 in Ras-Driven Lung Adenocarcinoma
Khalil, A.; Dinh, T.; Parks, M.; Obeng, R.; Gryder, B.; Kersak, A.; Wang, Y.; Maltas, J.; Bedrock, M.; Wei, X.; Faber, Z.; Rahm, M.; Scott, J.; LaFramboise, T.; Wang, Z.; McFarland, C. D.
10.1101/2025.03.15.642187 — cancer biology — Posted on 2025-03-17
2463 SRSF3 is oncogenic in breast but tumor-suppressive in liver by differential regulation of gene expression
Yu, L.; Ajiro, M.; Lobanov, A.; Cam, M.; Majerciak, V.; Karim, B.; Gotte, D.; Deng, C.; Lowy, D.; Webster, N. J. G.; Zheng, Z.-M.
10.1101/2025.03.14.643315 — cancer biology — Posted on 2025-03-17
2464 Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss
Kalla, J.; Dillinger, T.; Pavlovicova, Z.; Jacob, R.; Atas, E.; Baskan, A.; Draganic, K.; Tiefenbacher, A.; Limberger, T.; Mair, T.; Wasinger, G.; Villanti, L.; Kubicek, S.; Kenner, L.; Egger, G.
10.1101/2025.03.14.643296 — cancer biology — Posted on 2025-03-17
2470 A scalable framework for current steering at single-neuron resolution
Vasireddy, P. K.; Vilkhu, R. S.; Lotlikar, A.; Brown, J. B.; Gogliettino, A.; Phillips, A. J.; Kato, E.; Hottowy, P.; Sher, A.; Litke, A.; Mitra, S.; Shah, N.; Chichilnisky, E. J.
10.1101/2025.03.14.643392 — bioengineering — Posted on 2025-03-17
2473 Capsule-Based Single-Cell Genome Sequencing
Mullaney, D. B.; Sgrizzi, S. R.; Mai, D.; Campbell, I.; Huang, Y.; Sinkunas, A.; Kerr, D. L.; Browning, V. E.; Eisenach, H. E.; Sims, J. N.; Nichols, E. K.; Lapointe, C. P.; Amimura, Y.; Harris, K.; Zilionis, R.; Srivatsan, S. R.
10.1101/2025.03.14.643253 — genomics — Posted on 2025-03-17
2476 High-throughput single cell -omics using semi-permeable capsules
Baronas, D.; Zvirblyte, J.; Norvaisis, S.; Leonaviciene, G.; Goda, K.; Mikulenaite, V.; Kaseta, V.; Sablauskas, K.; Griskevicius, L.; Juzenas, S.; Mazutis, L.
10.1101/2025.03.14.642805 — genomics — Posted on 2025-03-17
2478 Stable hypermutators revealed by the genomic landscape of DNA repair genes among yeast species
Goncalves, C.; Steenwyk, J. L.; Rinker, D.; Opulente, D. A.; LaBella, A. L.; Harrison, M.-C.; Wolters, J. F.; Zhou, X.; Shen, X.-X.; Covo, S.; Groenewald, M.; Hittinger, C. T.; Rokas, A.
10.1101/2025.03.15.643480 — evolutionary biology — Posted on 2025-03-17
2481 Contribution of mesopelagic fish and cephalopods to the diet of rorquals (Balaenoptera spp) and sperm whales (Physeter macrocephalus) beyond their feeding grounds
Claver, C.; Garcia de Amezaga, L.; Mendibil, I.; Canals, O.; Prieto, R.; Cascao, I.; Oliveira, C.; Silva, M.; Rodriguez-Ezpeleta, N.
10.1101/2025.03.14.643344 — ecology — Posted on 2025-03-17
2482 MoveTraits - A database for integrating animal behaviour into trait-based ecology
Beumer, L. T.; Hertel, A. G.; Royaute, R.; Tucker, M. A.; Albrecht, J.; Beltran, R.; Cagnacci, F.; Davidson, S. C.; Dejid, N.; Kays, R.; Koelzsch, A.; Lohr, A.; Neuschulz, E. L.; Safi, K.; Scharf, A. K.; Schleuning, M.; Wikelski, M.; Mueller, T.
10.1101/2025.03.15.643440 — ecology — Posted on 2025-03-17
2483 'surveyjoin': A Standardized Database of Fisheries Bottom Trawl Surveys in the Northeast Pacific Ocean
Ward, E.; English, P. A.; Rooper, C. N.; Ferriss, B. E.; Whitmire, C. E.; Wetzel, C. R.; Barnett, L. A.; Anderson, S. C.; Thorson, J. T.; Johnson, K. F.; Indivero, J.; Markowitz, E. H.
10.1101/2025.03.14.643022 — ecology — Posted on 2025-03-17
2484 Diverse crop rotations off-set yield-scaled nitrogen losses via denitrification
Saghai, A.; Smith, M. E.; Vico, G.; Banerjee, S.; Edlinger, A.; Garcia-Palacios, P.; Garland, G.; van der Heijden, M. G. A.; Herzog, C.; Maestre, F. T.; Pescador, D. S.; Philippot, L.; Rillig, M. C.; Romdhane, S.; Bommarco, R.; Hallin, S.
10.1101/2025.03.15.643431 — ecology — Posted on 2025-03-17
2486 Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis
Bhamidipati, K.; McIntyre, A. A. B.; Kazerounian, S.; Ce, G.; Tran, M.; Prell, S. A.; Lau, R.; Khedgikar, V.; Altmann, C.; Small, A.; Wong, V.; Madhu, R.; Presti, S.; Anufrieva, K. S.; Blazar, P. E.; Lange, J. K.; Seifert, J.; Accelerating Medicines Partnership: RA/SLE Network, Accelerating Medicines Partnership: AMP-AIM, ; Moreland, L. W.; Croft, A. P.; Lewis, M. J.; Thomas, R.; Jonsson, A. H.; Pitzalis, C.; Gravallese, E. M.; Brenner, M. B.; Korsunsky, I.; Wechalekar, M. D.; Wei, K.
10.1101/2025.03.14.642821 — immunology — Posted on 2025-03-17
2487 Intrinsic OASL expression licenses interferon induction during influenza A virus infection
Rivera-Cardona, J.; Mahajan, T.; Kakuturu, N. R.; Teo, Q. W.; Lederer, J.; Thayer, E. A.; Rowland, E. F.; Heimburger, K.; Sun, J.; McDonald, C. A.; Mickelson, C. K.; Langlois, R. A.; Wu, N. C.; Milenkovic, O.; Maslov, S.; Brooke, C. B.
10.1101/2025.03.14.643375 — immunology — Posted on 2025-03-17
2490 Claudin 1-mediated positioning of DC1 to mTECs is essential for antigen transfer-coupled DC1 maturation and maintenance of central tolerance
Brezina, J.; Brabec, T.; Machac, D.; Voboril, M.; Ballek, O.; Paces, J.; Sykora, V.; Jancovicova, K.; Valter, E.; Kovacova, K.; Manning, J.; Tahtahova, V.; Cepkova, A.; Dobesova, M.; Dobes, J.; Kubovciak, J.; Kolar, M.; Kasparek, P.; Sedlacek, R.; Stepanek, O.; Cerny, J.; Tsukita, S.; Malissen, B.; Anderson, G.; Filipp, D.
10.1101/2025.03.15.643437 — immunology — Posted on 2025-03-17
2491 Improving Statistical Rigor in Animal Aging Research by Addressing Clustering and Nesting Effects: Illustration with the National Institute on Aging's Intervention Testing Program Data
Parker, E. S.; Golzarri-Arroyo, L.; Dickinson, S.; Henschel, B.; Becerra-Garcia, L.-E.; Mokalla, T. R.; Robertson, O. C.; Thapa, D. K.; Vorland, C. J.; Allison, D. B.
10.1101/2025.03.14.642436 — systems biology — Posted on 2025-03-17
2492 MICOMWeb: a website for microbial community metabolic modeling of the human gut
Fresno, C.; Oropeza-Valdez, J. J.; Alvarado-Luis, P. I.; Pena-Gonzalez, P.; Tovar, A. R.; Torres, N.; Diener, C.; Gibbons, S.; Resendis-Antonio, O.
10.1101/2025.03.14.643140 — systems biology — Posted on 2025-03-17
2494 Endocytosis of the damage-associated molecular pattern receptor PEPR1 is BAK1-dependent.
Claus, L. A. N.; Ortiz-Morea, F. A.; Yang, S.-L.; Yekondi, S.; Yeo, I.-C.; Vanhoutte, I.; Vukasinovic, N.; Ma, Q.; De Smet, I.; He, P.; Shan, L.; Russinova, E.
10.1101/2025.03.15.643409 — plant biology — Posted on 2025-03-17
2495 Impacts of climate change on fonio millet: in-vitro seed germination and suitability modelling of an important indigenous West African crop
Burton, G. P.; Mireku Botey, H.; Ceci, P.; Chater, C.; Gutaker, R. M.; Jackson, A. C.; Ryan, P.; Seal, C. E.; Turnbull, C. G. N.; Vorontsova, M. S.; Mattana, E.; Ulian, T.
10.1101/2025.03.14.641845 — plant biology — Posted on 2025-03-17
2496 Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation
Holmes, M.; Wang, Z. J.; Doste, R.; Camps, J.; Martinez-Navarro, H.; Smith, H.; Tomek, J.; Rodriguez, B.
10.1101/2025.03.14.643310 — physiology — Posted on 2025-03-17
2497 The Effect of Ex-vivo Gravid Uterine Support on Umbilical Vessel Flow Velocities and Ductus Arteriosus Patency
Schuh, J. M.; Morelos, A.; Abebrese, E. L.; Jones, D.; Stocke, N.; Starkey, N. W.; Salazar, J. H.
10.1101/2025.03.14.643369 — physiology — Posted on 2025-03-17
2498 Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental Lynch syndrome
Garcia Castillo, L.; Ferrero, G.; Blazevits, O.; Francescato, G.; Thaseen, A. E.; Cortez, N. E.; Beltra, M.; Tarallo, S.; Pardini, B.; Costelli, P.; Naccarati, A.; Longo, V. D.; Penna, F.
10.1101/2025.03.14.643045 — pathology — Posted on 2025-03-17
2499 Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules
Bond, M. J.; Golden, R. P.; DiGiovanni, G.; Howard, B.; Sarott, R. C.; Karim, B. A.; Gourisankar, S. P.; Alexe, G.; Ross, K.; Gray, N. S.; Stegmaier, K.
10.1101/2025.03.14.643353 — cancer biology — Posted on 2025-03-17
2500 Sex Differences in the Cancer Proteome
Zhu, C.; Zeltser, N.; Oh, J.; Li, C. H.; Boutros, P. C.
10.1101/2025.03.14.643396 — cancer biology — Posted on 2025-03-17
2502 Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
O'Neill, A.; Zakaria, N.; Egan, H.; Corry, S. M.; Bull, C.; Leonard, N. A.; O'Meara, C.; Howard, L.; Walsh, A.; Reidy, E.; Che, J.; Peng, L.; Cao, L.; Egan, L. J.; Ritter, T.; Sheehan, M.; Canney, A.; Culligan, K.; Hogan, A. M.; Hynes, S. O.; Dunne, P. D.; O'Dwyer, M.; Treacy, O.; Ryan, A. E.
10.1101/2025.03.14.642985 — cancer biology — Posted on 2025-03-17
2503 Homoharringtonine Promotes FTO Degradation to Suppress LILRB4-Mediated Immune Evasion in Acute Monocytic Leukemia
Huang, F.; Luo, X.; Zhang, M.; Jin, L.; Sun, W.; Chen, P.; Hong, X.; Xu, C.; Jiang, M.; Hu, D.; Zhang, B.; Hu, S.; Yang, C.; Gao, R.; Zeng, J.; Lu, Q.; Luo, Q.; Wu, J.; Chen, S.
10.1101/2025.03.15.643466 — cancer biology — Posted on 2025-03-17
2504 Antigenic cancer persister cells survive direct T cell attack
Wang, M. X.; Mauch, B. E.; Williams, A. F.; Barazande-Pour, T.; Hoffmann, F. A.; Harris, S. H.; Lathrop, C. P.; Turkal, C. E.; Yung, B. S.; Paw, M. H.; Gervasio, D. A. G.; Tran, T.; Stuhlfire, A. E.; Guo, T.; Daniels, G. A.; Park, S. J.; Gutkind, J. S.; Hangauer, M. J.
10.1101/2025.03.14.643359 — cancer biology — Posted on 2025-03-17
2510 BioBatchNet: A Dual-Encoder Framework for Robust Batch Effect Correction in Imaging Mass Cytometry
Liu, H.; Zhang, S.; Mao, S.; Zhao, Q.; Zhou, Y.; Gilmore, A. P.; A. Alvarez, M.; Zhou, H.
10.1101/2025.03.15.643447 — bioinformatics — Posted on 2025-03-17
2514 Genotype-free individual genome reconstruction of Multiparental Population Models by RNA sequencing data
Choi, K.; Lloyd, M. W.; He, H.; Gatti, D. M.; Philip, V. M.; Raghupathy, N.; Vincent, M.; Lek, S.; Gyuricza, I. G.; Munger, S. C.; Attie, A. D.; Keller, M. P.; Chesler, E. J.; Broman, K. W.; SRIVASTAVA, A.; Churchill, G. A.
10.1101/2020.10.11.335323 — bioinformatics — Posted on 2025-03-17
2517 MAIS: an in-vitro sandbox enables adaptive neuromodulation via scalable neural interfaces
Chen, H.; Chen, F.; Chen, X.; Liu, Y.; Xu, J.; Li, J.; Bao, X.; Chen, Y.; Sun, H.; Jiang, J.; Ye, F.; Su, J.; Gen, Y.; Ye, F.; Wang, Z.; Liu, L.; Hexige, S.; Li, X.; Ma, L.; Shuai, J.
10.1101/2025.03.15.641656 — bioengineering — Posted on 2025-03-17
2519 Rapid Automated Isolation and Concentration of Bacteria from Blood Samples
Osaid, M.; Miguelez, M. H. M.; Baryak, B.; Ozmen-Capin, B. B.; Ozenci, V.; Wijngaart, W. v. d.
10.1101/2025.03.14.643371 — bioengineering — Posted on 2025-03-17
2520 A fatigue-resistant myoneural actuator for implantable biohybrid systems
Song, H.; Herrera-Arcos, G.; Friedman, G. N.; Yeon, S. H.; He, C.; Gutierrez-Arango, S.; Sinha, S.; Herr, H. M.
10.1101/2025.03.14.642606 — bioengineering — Posted on 2025-03-17
2521 Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier
Sorets, A.; Schwensen, K.; Francini, N.; Kjar, A.; Lyons, S.; Park, J.; Palmer, D.; Abdulrahman, A.; Cowell, R.; Katdare, K.; Hoogenboezem, E.; Wang, A.; Dani, N.; Duvall, C.; Lippmann, E.
10.1101/2025.03.14.642142 — bioengineering — Posted on 2025-03-17
2523 Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation
Clavell-Revelles, P.; Reese, F.; Carbonell-Sala, S.; Degalez, F.; Oliveros, W.; Arnan, C.; Guigo, R.; Mele, M.
10.1101/2025.03.14.643250 — genomics — Posted on 2025-03-17
2524 Chromosome-level genome assembly and annotation of the chaetognath Flaccisagitta enflata
Guiglielmoni, N.; Eitel, M.; Moreau, P.; Krebs, S.; Vermeij, M.; Koszul, R.; Flot, J.-F.
10.1101/2025.03.14.643333 — genomics — Posted on 2025-03-17
2525 Pangenome analyses of tea plant reveal structural variations driven gene expression alterations and agronomic trait diversification
Tao, L.; Zhu, J.; Hu, J.; Wu, J.; Chen, C.; Li, Y.; Li, F.; Chen, H.; Huang, S.; Zhou, Q.; Zhao, Y.; Hu, Y.; Liu, S.; Dong, K.; Chen, L.; Liu, B.; Wan, X.; Xia, E.; Zhou, Y.; wei, c.
10.1101/2025.03.14.643311 — genomics — Posted on 2025-03-17
2526 Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells
Seo, H.; Cuddleston, W. H.; Fu, T.; Navarro, E.; Parks, M.; Allan, A.; Efthymiou, A. G.; Breen, M. S.; Xiao, X.; Raj, T.; Humphrey, J.
10.1101/2025.03.14.643382 — genomics — Posted on 2025-03-17
2528 Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing
Gautam, B.; Jarvis, B. A.; Esfahanian, M.; McGinn, M.; Williams, D.; Liu, S.; Phippen, M. E.; Heller, N. J.; Wesley, T. L.; Phippen, W. B.; Ulmasov, T.; Marks, M. D.; Chopra, R.; Sedbrook, J. C.
10.1101/2025.03.15.643467 — genetics — Posted on 2025-03-17
2534 Sero-epidemiology of Rift Valley fever virus in ruminant livestock in The Gambia
Jarra, E.; Beyai, Y.; Mendy, A.; Ceesay, O.; Ceesay, A.; Daffeh, K.; Haydon, D. T.; Cleaveland, S.
10.1101/2025.03.14.640388 — ecology — Posted on 2025-03-17
2537 Human dimension of Holocene wildfire dynamics in boreal eastern Siberia
Glückler, R.; Dietze, E.; Andreev, A. A.; Kruse, S.; Zakharov, E. S.; Baisheva, I. A.; Stieg, A.; Tsuyuzaki, S.; Pestryakova, L. A.; Herzschuh, U.
10.1101/2025.03.14.643308 — ecology — Posted on 2025-03-17
2538 Microbial sedimentary DNA from a cultural landscape disentangles the impacts of humans and nature over the past 13.5 thousand years
Wang, Y.; Schleheck, D.; Marinova, E.; Wessels, M.; Schaller, S.; Anselmetti, F. S.; Schwalb, A.; Pedersen, M. W.; Epp, L. S.
10.1101/2025.03.14.642998 — ecology — Posted on 2025-03-17
2540 17q21.31 locus regulates Parkinson's disease relevant pathways through KANSL1 activity
Hicks, A. R.; O'Callaghan, B.; Brenton, J. W.; Grant-Peters, M.; Fairbrother-Browne, A.; Rocamora Perez, G.; Loh, C. A.; Reynolds, R. H.; Gustavsson, E. K.; Montgomery, K.; Tsalenchuk, M.; Real, R.; Morris, H.; Lunnon, K.; Marzi, S. J.; Jaunmuktane, Z.; Hardy, J.; Plun-Favreau, H.; Ryten, M.
10.1101/2025.03.17.641409 — neuroscience — Posted on 2025-03-17
2542 Pioneering New Breeding Pathways with 3PaTec: Unlocking the Power of Polyspermy-Induced Triparentage for Sustainable Crop Development
Joshi, S.; Beer, C.; Mao, Y.; Baum, T.; Tekleyohans, D.; Bubenheim, C.; Palovaara, J.; Czarnecki, O.; Nakel, T.; Gross-Hardt, R.
10.1101/2025.03.14.643266 — plant biology — Posted on 2025-03-17
2543 Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice
Elser, B. A.; Hing, B.; Eliasen, S.; Afrifa, M. A.; Meurice, N.; Rimi, F.; Chimenti, M.; Schulz, L. C.; Dailey, M. E.; Gibson-Corley, K. N.; Stevens, H. E.
10.1101/2025.03.16.643434 — pharmacology and toxicology — Posted on 2025-03-17
2545 Prototaxites was an extinct lineage of multicellular terrestrial eukaryotes
Loron, C. C.; Cooper, L. M.; McMahon, S.; Jordan, S. F.; Gromov, A. V.; Humpage, M.; Pichevin, L.; Vondracek, H.; Alexander, R.; Rodriguez Dzul, E.; Brasier, A. T.; Hetherington, A. J.
10.1101/2025.03.14.643340 — paleontology — Posted on 2025-03-17
2546 Targeting processive transcription for Myc-driven circuitry in medulloblastoma
Martin Sobral, L.; Walker, F. M.; Madhaven, K.; Janko, E.; Donthula, S.; Balakrishnan, I.; Wang, D.; Pierce, A.; Haag, M. M.; Carstens, B. J.; Serkova, N. J.; Foreman, N. K.; Venkataraman, S.; Veo, B.; Vibhakar, R.; Dahl, N. A.
10.1101/2025.03.14.643337 — cancer biology — Posted on 2025-03-17
2550 A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening
Caterer, Z.; Horejsi, R. V.; Weber, C.; Mathisen, B.; Nelson, C. N.; Bagatta, M.; Coughlin, I.; Wettstein, M.; Kulshrestha, A.; Lee, H. S. B.; Nunn, L. R.; Zamanian, M.; Wheeler, N. J.
10.1101/2025.03.14.643077 — bioinformatics — Posted on 2025-03-17
2552 Autologous human iPSC-derived Alveolus-on-Chip reveals early pathological events of M. tuberculosis infection
Luk, C. H.; Conway, G.; Goh, K. J.; Fearns, A.; Rodriguez-Hernandez, I.; D'Antuono, R.; Day, N. J.; Athanasiadi, N.; Pellegrino, E.; Hobi, N.; Stucki, J.; Gutierrez, M. G.
10.1101/2025.03.14.643230 — bioengineering — Posted on 2025-03-17
2553 Benchmarking of variant pathogenicity prediction methods using a population genetics approach
Gudkov, M.; Thibaut, L.; Monger, S.; Das, D.; Congenital Heart Disease Synergy Study group, ; Winlaw, D. S.; Dunwoodie, S. L.; Giannoulatou, E.
10.1101/2025.03.16.643565 — genomics — Posted on 2025-03-17
2557 FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
Li, J. T.-Y.; Amiri, M.; Kailasam, S.; Sun, J.; Sonenberg, N.; Ortega, J.; Sossin, W. S.
10.1101/2025.02.21.639553 — neuroscience — Posted on 2025-03-17
2559 Centella asiatica Tissue Culture-Derived Extracellular Vesicles: A Multifaceted Approach to Skincare Applications
Chang, T.-M.; Wu, C.-C.; Huang, H.-C.; Wang, S.-S.; Chuang, C.-H.; Kao, P.-L.; Tang, W.-H.; Liu, L. T.-C.; Qiu, W.-Y.; Percec, I.; Chen, C.; Kuo, T.-Y.
10.1101/2024.12.03.624435 — pharmacology and toxicology — Posted on 2025-03-17
2560 Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models
Smer-Barreto, V.; Elliott, R. J. R.; Dawson, J. C.; Lorente-Macias, A.; Unciti-Broceta, A.; Oyarzun, D. A.; Carragher, N. O.
10.1101/2025.03.06.641926 — cancer biology — Posted on 2025-03-17
2562 Epigenetic coordination of transcriptional and translational programs in hypoxia
Watt, K.; Dauber, B.; Szkop, K. J.; Lee, L.; Jovanovic, P.; Chen, S.; Palia, R.; Vassalakis, J. A.; Cooper, T. T.; Papadopoli, D.; Masvidal, L.; Jewer, M.; Tandoc, K.; Plummer, H.; Lajoie, G. A.; Topisirovic, I.; Larsson, O.; Postovit, L.-M.
10.1101/2023.09.16.558067 — cancer biology — Posted on 2025-03-17
2563 HazardPyMatch: A Tool for identifying reproductive and other hazards in scientific laboratories
Parker, E. M.; Zavitsanou, A.-M.; Liff, C.; Jeurissen, D.; El Houda MIMOUNI, N.; Succi, I.; Rogers, E.; Liistro, M.
10.1101/2025.03.14.643365 — bioinformatics — Posted on 2025-03-17
2565 An nf-core framework for the systematic comparison of alternative modeling tools: the multiple sequence alignment case study
Santus, L.; Espinosa-Carrasco, J.; Rauschning, L.; Mir-Pedrol, J.; Trujnara, I.; Vignoli, A.; Mansouri, L.; Baltzis, A.; Floden, E. W.; Di Tommaso, P.; Garriga Nogales, E.; Gudys, A.; Deorowicz, S.; Gilchrist, C. L. M.; Steinegger, M.; Notredame, C.
10.1101/2025.03.14.642603 — bioinformatics — Posted on 2025-03-17
2569 Horizontal gene transfers are widespread across termite genomes but do not confer metabolic innovations
Liu, C.; Hellemans, S.; Kinjo, Y.; Mikhailova, A. A.; Aumont, C.; Weng, Y. M.; Bucek, A.; Husnik, F.; Sobotnik, J.; Harrison, M.; mcmahon, D.; bourguignon, t.
10.1101/2025.03.16.643567 — genomics — Posted on 2025-03-17
2570 Genetic basis of the evolution of vertical bars in clownfishes
Fitzgerald, L. M.; Latrille, T.; Marcionetti, A.; Gaboriau, T.; Hartasanchez, D. A.; Salamin, N.
10.1101/2025.03.14.643259 — evolutionary biology — Posted on 2025-03-17
2571 Comparative analysis of convergent jellyfish eyes reveals extensive differences in expression of vision-related genes
Picciani, N.; Berger, C. A.; Nielsen, S.; Musser, J.; Oel, A. P.; Stoilova, M.; Arendt, D.; Garm, A.; Oakley, T. H.
10.1101/2025.03.14.642713 — evolutionary biology — Posted on 2025-03-17
2572 Chromatin organization controls nuclear stiffness
Romero, H.; Amiri, A.; Pabba, M. K.; Zhang, H.; Berg, V.; Arroyo, M.; Prorok, P.; Trautwein, N.; Laube, B.; Dietz, C.; Stark, R. W.; Cardoso, M. C.
10.1101/2025.03.14.643219 — cell biology — Posted on 2025-03-17
2574 Microbial source tracking using metagenomic analysis from Cochin Estuary
A, P.; Vijayan, J.; Catena, M.; Pazhayamadom, D. G.; Phadke, N.; Nair, M.
10.1101/2025.03.14.643239 — microbiology — Posted on 2025-03-17
2575 Lifetime physical activity and network attack tolerance contribute to the preservation of motor function in Parkinson's disease
Asendorf, A. L.; Guerra, E.; Dzialas, V.; Bankwinkler, M.; Theis, H.; Hagemann, N.; Moellenhoff, K.; van Eimeren, T.; Hoenig, M.
10.1101/2025.03.14.643226 — neuroscience — Posted on 2025-03-17
2578 Spatial ploidy inference using quantitative imaging
Russell, N. J.; Belato, P. B.; Oliver, L. S.; Chakraborty, A.; Roeder, A. H. K.; Fox, D. T.; Formosa-Jordan, P.
10.1101/2025.03.11.642217 — developmental biology — Posted on 2025-03-17
2580 The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins
Bayless, A. M.; Song, L.; Sorbello, M.; Ogden, S. C.; Todd, T. S.; Flint, A.; Maruta, N.; Tulu, J.; Drenichev, M.; Ntoukakis, V.; Ve, T.; Mobli, M.; Wan, L.; Liu, Q.; Dangl, J. L.; Kobe, B.; Grant, M.; Nishimura, M. T.
10.1101/2025.03.15.643477 — plant biology — Posted on 2025-03-17
2581 Targeting Monoallelic CREBBP/EP300 Mutations in Germinal Center-Derived B-Cell Lymphoma with a First-in-Class Histone Acetyltransferase Activator
Liu, Y.; Piorczynski, T. B.; Estrella, B.; Ricker, E. C.; Pazos, M.; Gonzalez, Y.; Tolu, S. S.; Ryu Tiger, Y. K.; Karan, C.; Cremers, S.; Nandakumar, R.; Honig, B.; Hwang, H.; Kelleher, N. L.; Camarillo, J. M.; Abshiru, N. A.; Amengual, J. E.
10.1101/2025.03.13.642871 — cancer biology — Posted on 2025-03-17
2582 Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy
Spetz, M. R.; Kim, H.; Chavarria, D.; Conger, D. J.; Shattuck-Brandt, R.; Shekharan, S. R.; Shostak, A.; Ligocki, A. P.; Brien, H. J.; Embalabala, R. J.; Mobley, B. C.; Schrag, M. S.; Lippmann, E. S.; Brunger, J. M.
10.1101/2025.03.12.642808 — bioengineering — Posted on 2025-03-17
2583 Distribution of myogenic stem cell activator, hepatocyte growth factor, in skeletal muscle extracellular matrix and effect of short-term disuse and reloading
Kuwakado, S.; Elgaabari, A.; Zushi, K.; Tanaka, S.; Seki, M.; Kaneko, R.; Matsuyoshi, Y.; Suzuki, T.; Kawaguchi, K.; Nakashima, Y.; Tatsumi, R.
10.1101/2025.03.14.643206 — biochemistry — Posted on 2025-03-17
2584 Methylome and transcriptome analysis reveals the impact of psychological stress on the skin
Li, B.; Zou, Y.; Tian, S.; Gonda, L.; Mahns, A.; Huang, T.; Kolbe, L.; Shi, Y.; Wang, S.
10.1101/2025.03.14.643220 — genetics — Posted on 2025-03-17
2585 Longitudinal analysis of retinal cell state transitions in RB1-deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastoma
Ye, K.; Wang, Y.; Xu, P.; Xie, B.; Wu, S.; Zhang, W.; Gao, G.; Zheng, D.; Song, X.; Zhang, S.; Guo, F.; Li, Y.; Liu, Y.; Wang, J.; Sui, R.; Zhong, X.
10.1101/2025.03.13.642537 — cell biology — Posted on 2025-03-17
2586 Photoperiodic history modulates the response of the saccus vasculosus transcriptome to SW water exposure in Atlantic salmon
West, A. C.; Wood, S. H.; Iversen, M.; van Dalum, M. J.; Jorgensen, E. H.; Sandve, S. R.; Hazlerigg, D. G.
10.1101/2025.03.14.643326 — molecular biology — Posted on 2025-03-17
2587 Registered Report: Replication and Extension of Nozaradan, Peretz, Missal and Mouraux (2011)
Nave, K. M.; Hannon, E. E.; Snyder, J. S.; Replication of Auditory Frequency Tagging Consortium,
10.1101/2025.03.13.643168 — neuroscience — Posted on 2025-03-17
2592 A rapid and efficient red-light-activated Cre recombinase system for genome engineering in mammalian cells and transgenic mice
Zhou, Y.; Wei, Y.; Yin, J.; Kong, D.; Li, W.; Wang, X.; Yao, Y.; Huang, Q.; Li, L.; Liu, M.; Qiao, L.; Li, H.; Zhao, J.; Zhong, T. P.; Li, D.; Duan, L.; Guan, N.; Ye, H.
10.1101/2025.03.16.643490 — synthetic biology — Posted on 2025-03-16
2595 N2B27 media formulations influence gastruloid development
Balayo, T.; Lunn, S.; Pascual-Mas, P.; Fiuza, U.-M.; Vasudevan, A.; Frenster, J. D.; Galloon, H. Y.; Peirats, R. F.; Martinez Arias, A.; Dias, A.; Turner, D. A.
10.1101/2025.03.15.643474 — developmental biology — Posted on 2025-03-16
2596 Systematic comparison of dCas9-based DNA methylation epimodifiers over time indicates efficient on-target and widespread off-target effects
Pahlevan Kakhki, M.; Rangani, F.; Ewing, E.; Starvaggi Cucuzza, C.; Zheleznyakova, G.; Kalomoiri, M.; v, T. V. S.; Covacu, R.; Andreou, I.; Needhamsen, M.; Kular, L.; Jagodic, M.
10.1101/2025.03.15.641804 — molecular biology — Posted on 2025-03-16
2597 Structural Basis of Pseudomonas FapC Biofilm-Forming Functional Amyloid Formation
Hansen, K. H.; Golcuk, M.; Byeon, C. H.; Tunc, A.; Plechinger, E. B.; Conway, J. F.; Andreasen, M.; Gur, M.; Akbey, U.
10.1101/2025.03.15.642095 — microbiology — Posted on 2025-03-16
2598 Serum amyloid A3 deficiency modulates aortic immune composition and attenuates murine atherosclerosis progression
Chou, T.-Y.; Ye, Y.-Z.; Lien, C.-J.; Wang, J.-C.; Yang, C.-H.; Chen, Y.-T.; Chao, P.-A.; Lin, J.-D.
10.1101/2024.07.09.602634 — immunology — Posted on 2025-03-16
2603 Integration of Proxy Intermediate Omics traits into a Nonlinear Two-Step model for accurate phenotypic prediction
Yoshioka, H.; Mary-Huard, T.; Aubert, J.; Toda, Y.; Ohmori, Y.; Yamasaki, Y.; Tsujimoto, H.; Takahashi, H.; Nakazono, M.; Takanashi, H.; Fujiwara, T.; Tsuda, M.; Kaga, A.; Inaba, J.; Fuji, Y.; Hirai, M. Y.; Nose, Y.; Kumaishi, K.; Usui, E.; Kobori, S.; Sato, T.; Narukawa, M.; Ichihashi, Y.; Iwata, H.
10.1101/2025.03.14.643213 — bioinformatics — Posted on 2025-03-16
2605 Blocking IF3N delays bacterial translation initiation
Sanchez-Castro, A.; Penaranda, K.; Dallape, A.; Safdari, H.; Nakamoto, J. A.; Morici, M.; Vinogradova, D.; Paleskava, A.; Wilson, D.; Konevega, A. L.; Milon, P.
10.1101/2025.03.14.643242 — biochemistry — Posted on 2025-03-16
2606 Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Jaen Maisonet, I.; Sharafi, M.; Korchak, E. J.; Salazar-Chaparro, A.; Bratt, A.; Parikh, T.; Varca, A. C.; Shah, B.; Darnowski, M.; Chung, M.; Teh, W. P.; Che, J.; Bezsonova, I.; Buhrlage, S. J.
10.1101/2025.03.14.643379 — biochemistry — Posted on 2025-03-16
2607 PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity
Chhetri, G.; Badugu, S. B.; Petriman, N.-A.; Petersen, M. B.; Pitchai, G. P.; Guller, A. S.; Novotny, J.; Balarasa, B.; Ebbesen, M.; Larsen, F.; Ravnsborg, T.; Yadav, A. K.; Lunding, A.; Polasek-Sedlackova, H.; Jensen, O. N.; Ravnskjaer, K.; Brewer, J.; Madsen, J. G. S.; Andersen, J. S.; Somyajit, K.
10.1101/2025.03.15.641049 — biochemistry — Posted on 2025-03-16
2610 Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila
Sanchez-Cisneros, L. E.; Barrera-Velazquez, M.; Kromm, D.; Bun, P.; Merchant-Larios, H.; Rios-Barrera, L. D.
10.1101/2025.03.15.643376 — developmental biology — Posted on 2025-03-16
2612 Alzheimer's Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain Development
Wang, Y.; Lorentz, J.; Mohammadi, E.; Yilmaz, D. E.; Sgouras, T.; Guo, Y.; Pizzirusso, G.; Demetriou, A.; Nalvarte, I.; Schultzberg, M.; Li, X.
10.1101/2025.03.16.643546 — developmental biology — Posted on 2025-03-16
2613 Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine de novo synthesis
Lin, J.-M. G.; Nguyen, T.-A.; Marques, A.-S. M. C.; Scrofani, L.; Daum, D.; Bauer, L. G.; Cheng, C.; D'Angelo, L.; Sanchez, J.; Bueschl, C.; Buphamalai, P.; Siklos, M.; Genger, J.-W.; Hofstaetter, G.; Runggatscher, K.; Guertl, B.; Liu, Y.; Hansen, J.; Koren, A.; Froese, D. S.; Rosenblatt, D. S.; Klavins, K.; Bergthaler, A.; Menche, J.; Hannich, J. T.; Sdelci, S.; Huber, K. V. M.; Kubicek, S.
10.1101/2025.03.16.643506 — molecular biology — Posted on 2025-03-16
2616 A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase
Engel, A.; Wagner, V.; Hahn, O.; Foltz, A. G.; Atkins, M.; Beganovic, A.; Guldner, I. H.; Lu, N.; Saksena, A.; Fischer, U.; Ludwig, N.; Meese, E.; Wyss-Coray, T.; Keller, A.
10.1101/2025.03.15.643430 — molecular biology — Posted on 2025-03-16
2617 Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Trillo-Muyo, S.; Dolan, B.; Svensson, F.; Vickers, T. J.; Arike, L.; Garcia-Bonete, M.-J.; Gustafsson, J. K.; Wandall, H. H.; Fleckenstein, J. M.; Hansson, G. C.; van der Post, S.
10.1101/2025.03.16.643548 — molecular biology — Posted on 2025-03-16
2619 Development of novel high-affinity nanobodies against EGFR for cancer therapy
Heitrich, M.; Fernandez, M.; Aguilar-Cortes, D. C.; Werbajh, S.; Canziani, G.; Zylberman, V.; Ripari, L. B.; Videla-Richardson, G. A.; Malchiodi, E. L.; Podhajcer, O. L.; Vinzon, S. E.
10.1101/2025.03.16.643542 — molecular biology — Posted on 2025-03-16
2620 Replicative selfish genetic elements are driving rapid pathogenic adaptation of Enterococcus faecium
Grieshop, M. P.; Behr, A. A.; Bowden, S.; Lin, J. D.; Molari, M.; Reynolds, G. Z.; Brooks, E. F.; Doyle, B.; Rodriguez-Nava, G.; Salinas, J. L.; Banaei, N.; Bhatt, A. S.
10.1101/2025.03.16.643550 — microbiology — Posted on 2025-03-16
2621 Taxonomically different symbiotic communities of sympatric Arctic sponge species show functional similarity with specialization at species level
Rusanova, A.; Mamontov, V.; Ri, M.; Meleshko, D.; Trofimova, A.; Fedorchuk, V.; Ezhova, M.; Lyupina, Y.; Finoshin, A.; Isaev, A.; Sutormin, D.
10.1101/2025.03.15.643485 — microbiology — Posted on 2025-03-16
2623 Rapid modulation of choice behavior by ultrasound on the human frontal eye fields
Farboud, S.; Kop, B. R.; Koolschijn, R. S.; Walstra, S. L. Y.; Marques, J. P.; Chetverikov, A.; Medendorp, W. P.; Verhagen, L.; den Ouden, H. E. M.
10.1101/2025.03.16.643494 — neuroscience — Posted on 2025-03-16
2625 Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimers disease
Marongiu, R.; Platholi, J.; Park, L.; Yu, F.; Sommer, G.; Woods, C.; Milner, T. A.; Glass, M. J.
10.1101/2025.03.14.643317 — neuroscience — Posted on 2025-03-16
2626 Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington disease
Wu, Q.; Yao, M.; Liu, H.; Kakazu, A.; Ouyang, Y.; Liu, C.; Li, R.; Yang, F.; Wang, A.; Surasinghe, S.; Gerochi, D.; Baldo, B.; Jahn, S.; Tang, H.; Lu, H.; Wei, Z.; Duan, W.
10.1101/2025.03.16.643551 — neuroscience — Posted on 2025-03-16
2627 Cell-Free production of soybean leghemoglobins and non-symbiotic hemoglobin
Rocha, A. P.; Palmeiras, M. A.; de Oliveira, M. A.; Florentino, L. H.; Cataldi, T. R.; Bittencourt, D. M. C.; Labate, C.; Rosinha, G.; Rech, E.
10.1101/2025.03.16.643390 — synthetic biology — Posted on 2025-03-16
2631 Segger: Fast and accurate cell segmentation of imaging-based spatial transcriptomics data
Heidari, E.; Moorman, A.; Unyi, D.; Pasnuri, N.; Rukhovich, G.; Calafato, D.; Mathioudaki, A.; Chan, J.; Nawy, T.; Gerstung, M.; Pe'er, D.; Stegle, O.
10.1101/2025.03.14.643160 — bioinformatics — Posted on 2025-03-16
2632 Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment
Ramos-Valle, A.; Dominguez, A.; Navarro, N.; Marquez-Lopez, A.; Avino, A.; Eritja, R.; Fabrega, C.; Garcia-Hevia, L.; Fanarraga, M. L.
10.1101/2025.03.14.643079 — bioengineering — Posted on 2025-03-16
2633 Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex
Fan, Y.; Kuybu, F.; Cui, H.; Lammens, K.; Chen, J.-X.; Kugler, M.; Jung, C.; Hopfner, K.-P.
10.1101/2025.03.14.643254 — biochemistry — Posted on 2025-03-16
2634 Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions
Cheloha, R. W.; Sachdev, S.; Roy, S.; Saha, S.; Zhao, G.; Kumariya, R.; Creemer, B. A.; Yin, R.; Pierce, B.; Bewley, C. A.
10.1101/2025.03.14.643405 — biochemistry — Posted on 2025-03-16
2635 Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
Zhang, T.; Zhao, W.; Wirth, C.; Diaz-Gay, M.; Yin, J.; Cecati, M.; Marchegiani, F.; Hoang, P. H.; Leduc, C.; Baine, M. K.; Travis, W. D.; Sholl, L. M.; Joubert, P.; Sang, J.; McElderry, J. P.; Klein, A.; Khandekar, A.; Hartman, C.; Rosenbaum, J.; Colon-Matos, F. J.; Miraftab, M.; Saha, M.; Lee, O. W.; Jones, K. M.; Caporaso, N. E.; Wong, M. P.; Leung, K. C.; Hsiung, C. A.; Chen, C.-Y.; Homer, R.; Yang, S.-R.; Pesatori, A. C.; Consonni, D.; Yang, L.; Zhu, B.; Edell, E. S.; Santamaria, J. M.; Schabath, M. B.; Yendamuri, S. S.; Manczuk, M.; Lissowska, J.; Swiatkowska, B.; Mukeria, A.; Shangina, O
10.1101/2025.03.14.643063 — genomics — Posted on 2025-03-16
2636 Experimental reduction of land use increases invertebrate abundance but not diversity in grasslands
Staab, M.; Keller, A.; Achury, R.; Hilpert, A.; Hoelzel, N.; Prati, D.; Weisser, W. W.; Bluethgen, N.
10.1101/2025.03.14.643238 — ecology — Posted on 2025-03-16
2637 The influence of larval retention on coral recruitment
Gouezo, M.; Harrison, P.; Roff, G.; Chai, A.; Thomson, D.; Guglielmo, M.; Hardiman, L.; Forbes, A.; Gardner, B.; Doropoulos, C.
10.1101/2025.03.14.643210 — ecology — Posted on 2025-03-16
2640 Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA
Savy, V.; Stein, P.; Delker, D.; Estermann, M. A.; Papas, B. N.; Xu, Z.; Radonova, L.; Williams, C. J.
10.1101/2025.03.14.643362 — developmental biology — Posted on 2025-03-16
2641 Non-coding RNA Repertoire in Reef-Building Corals
Ashey, J.; Rodriquez-Casariego, J. A.; Durkin, K. M.; Bengtsson, Z.; Huffmyer, A. S.; White, S. J.; Becker, D. M.; Eirin-Lopez, J. M.; Putnam, H. M.; Roberts, S.
10.1101/2025.03.15.643469 — molecular biology — Posted on 2025-03-16
2644 The Chlamydia trachomatis secreted effector protein CT181 binds to Mcl-1 to prolong neutrophil survival
Faris, R.; Koch, R.; McCaslin, P.; Challagundla, N.; Steiert, B.; Andersen, S.; Smith, P.; Jabeena, C. A.; Yau, P.; Rudel, T.; Weber, M. M.
10.1101/2025.03.16.643443 — microbiology — Posted on 2025-03-16
2645 Degradation of rutin and genistein and the effect on human bacterial fecal populations of obese and non-obese
Jensen-Kroll, J.; Demetrowitsch, T.; Sprotte, S.; Brix, F.; Beckmann, A.; Schlicht, K.; Brinks, E.; Laudes, M.; Waschina, S.; Franz, C. M. A. P.; Schwarz, K.
10.1101/2025.03.16.643526 — microbiology — Posted on 2025-03-16
2646 Determining the core bacterial and fungal genera in table olive fermentations.
Ricciardi, A.; Lopez, F. N. A.; Giavalisco, M.; Pietrafesa, R.; Parente, E.
10.1101/2025.03.16.643505 — microbiology — Posted on 2025-03-16
2648 NOD1 ligand FK565 promotes atherogenesis and accumulation of NOD1high smooth muscle cells in atherosclerotic lesions
Zhang, X.-Y.; Jiang, X.-T.; Gistera, A.; Ding, Y.; Basbous, L.; Olofsson, P.; Religa, P.; Hansson, G. K.; Yan, Z.-Q.; E Johansson, M.
10.1101/2025.03.14.643082 — immunology — Posted on 2025-03-16
2650 Experimental change in personality: Overexpression of GDNF in the rat striatum converts the low exploratory phenotype into highly explorative
Harro, J.; O'Leary, A.; Norden, M.; Liiver, K.; Kanarik, M.; Garcia-Horsman, A.; Sakson, S.; Kupper, P.; Laugus, K.; Korulu, S.; Teino, I.; Org, T.; Parkkinen, I.; Kaart, T.; Lindholm, P.; Imbeault, S.; Poska, H.; Harvey, B. K.; Airavaara, M. T.; Shimmo, R.; Saarma, M.
10.1101/2025.03.16.643460 — neuroscience — Posted on 2025-03-16
2654 Direct cell-to-cell transmission of retrotransposons
Voichek, M.; Bernhard, A.; Novatchkova, M.; Handler, D.; Möseneder, P.; Rafanel, B.; Duchek, P.; Senti, K.-A.; Brennecke, J.
10.1101/2025.03.14.642691 — genetics — Posted on 2025-03-16
2655 Cyclin A2 Induces Human Adult Cardiomyocyte Cytokinesis and Elicits Cardiomyocyte Reprogramming and Dedifferentiation
Bouhamida, E.; Vadakke-Madathil, S.; Mathiyalagan, P.; Ranjan, A.; Khan, A.; Sherman, C.; Miller, P. E.; Ghetti, A.; Abi-Gerges, N.; Chaudhry, H. W.
10.1101/2024.03.01.583057 — cell biology — Posted on 2025-03-16
2657 Decoding gene regulatory networks controlling hypothalamic and prethalamic development.
Kim, D. W.; Duncan, L.; Xu, J.; Chang, M.; Sorensen, S. S.; Terrillin, C.; Kanold, P.; Place, E. S.; Blackshaw, S.
10.1101/2025.01.10.632449 — neuroscience — Posted on 2025-03-16
2658 Deep origins and distinct adaptations indicated for a glacial relict seal
Loytynoja, A.; Pohjoismaki, J.; Valtonen, M.; Laakkonen, J.; Morita, W.; Kunnasranta, M.; Vainola, R.; Olsen, M. T.; Auvinen, P.; Jernvall, J.
10.1101/2025.02.06.636115 — zoology — Posted on 2025-03-16
2660 Neurogenetic evidence that Dilp8 promotes developmental-stability via Lgr3-neuron oscillation
Zanini, R.; Pereirinha, J.; Fernandez-Acosta, M.; Casimiro, A. P.; Pinho, M.; Lage, L.; Garelli, A.; Heredia, F.; Gontijo, A. M.
10.1101/2024.11.26.625404 — neuroscience — Posted on 2025-03-16
2661 Continuous self-repair protects vimentin intermediate filaments from fragmentation
Tran, Q. D.; Lenz, M.; Lamour, G.; Paty, L.; Varela-Salgado, M.; Campillo, C.; Wioland, H.; JEGOU, A.; Romet-Lemonne, G.; Leduc, C.
10.1101/2024.09.02.610785 — biophysics — Posted on 2025-03-16
2662 Path2Omics: Enhanced transcriptomic and methylation prediction accuracy from tumor histopathology
Hoang, D.-T.; Shulman, E. D.; Dhruba, S. R.; Nair, N. U.; Barman, R. K.; Lalchungnunga, H.; Singh, O.; Nasrallah, M. P.; Stone, E. A.; Aldape, K.; Ruppin, E.
10.1101/2025.02.26.640189 — bioinformatics — Posted on 2025-03-16
2663 How Occam's razor guides human decision-making
Piasini, E.; Liu, S.; Chaudhari, P.; Balasubramanian, V.; Gold, J. I.
10.1101/2023.01.10.523479 — neuroscience — Posted on 2025-03-16
2664 Sub-second Fluctuation between Top-Down and Bottom-Up Modes Distinguishes Diverse Human Brain States
Park, Y.; Cha, Y.; Kim, H.; Kim, Y.; Woo, J. H.; Cho, H.; Mashour, G. A.; Xu, T.; Lee, U.; Hong, S.-J.; Honey, C.; Moon, J.-Y.
10.1101/2025.03.12.642768 — neuroscience — Posted on 2025-03-16
2665 AmygdalaGo-BOLT3D: A fast and valid transformer tracing boundaries of amygdala from brain images
Dong, B.; Zhou, Q.; Gao, P.; Jintao, W.; Xiao, J.; Wang, W.; Liang, P.; Lin, D.; He, H.; Zuo, X.-N.
10.1101/2024.08.11.607487 — neuroscience — Posted on 2025-03-16
2667 Trauma Under Psychedelics: How Psychoactive Substances Impact Trauma Processing
Netzer, O.; Magal, N.; Stern, Y.; Polinsky, T.; Gross, R.; Admon, R.; Salomon, R.
10.1101/2024.03.28.587237 — neuroscience — Posted on 2025-03-16
2668 New methods on the block: Taxonomic identification of archaeological bones in resin-embedded sediments through palaeoproteomics
Fagernäs, Z.; Troche, G.; Goldberg, P.; Hublin, J.-J.; McPherron, S. P.; Murphree, W. C.; Olsen, J. V.; Sandgathe, D.; Sirakov, N.; Soressi, M.; Tsanova, T.; Turq, A.; Wierer, M.; Welker, F.; Aldeias, V.
10.1101/2025.03.14.643068 — evolutionary biology — Posted on 2025-03-16
2669 Tree ring segmentation performance in highly disturbed trees using deep learning
Zambrano-Suarez, J. D.; Perez-Martin, J.; Manchado, A. M.-T.; Ballesteros Canovas, J. A.
10.1101/2025.03.14.643209 — ecology — Posted on 2025-03-16
2677 Genetic diversity and regulatory features of human-specific NOTCH2NL duplications
Real, T. D.; Hebbar, P.; Yoo, D.; Antonacci, F.; Pacar, I.; Diekhans, M.; Mikol, G. J.; Popoola, O. G.; Mallory, B.; Vollger, M. R.; Dishuck, P. C.; Guitart, X.; Rozanski, A. N.; Munson, K. M.; Hoekzema, K.; Ranchalis, J. E.; Neph, S. J.; Sedeno-Cortes, A. E.; Paten, B.; Salama, S.; Stergachis, A.; Eichler, E. E.
10.1101/2025.03.14.643395 — genomics — Posted on 2025-03-16
2678 The evolution of gene regulation in mammalian cerebellum development
Sarropoulos, I.; Sepp, M.; Yamada, T.; Schaefer, P. S. L.; Trost, N.; Schmidt, J.; Schneider, C.; Drummer, C.; Missbach, S.; Taskiran, I. I.; Hecker, N.; Bravo Gonzalez-Blas, C.; Kempynck, N.; Froemel, R.; Joshi, P.; Leushkin, E.; Arnskoetter, F.; Leiss, K.; Okonechnikov, K.; Lisgo, S.; Palkovits, M.; Paabo, S.; Cardoso-Moreira, M.; Kutscher, L. M.; Behr, R.; Pfister, S. M.; Aerts, S.; Kaessmann, H.
10.1101/2025.03.14.643248 — evolutionary biology — Posted on 2025-03-16
2679 A hippocampal population code for rapid generalization
Tang, W.; Chang, H.; Liu, C.; Perez-Hernandez, S.; Zheng, W. Y.; Park, J.; Oliva, A.; Fernandez-Ruiz, A.
10.1101/2025.03.15.643456 — neuroscience — Posted on 2025-03-16
2680 Relative strength variability measures for brain structural connectomes and their relationship with cognitive functioning
Yeung, H. W.; Buchanan, C. R.; Moodie, J. E.; Deary, I.; Tucker-Drob, E. M.; Bastin, M. E.; Whalley, H. C.; Smith, K. M.; Cox, S. R.
10.1101/2025.03.15.643458 — neuroscience — Posted on 2025-03-16
2682 TimberTracer: A Comprehensive Framework for the Evaluation of Carbon Sequestration by Forest Management and Substitution of Harvested Wood Products.
Boukhris, I.; Collalti, A.; Lahssini, S.; Dalmonech, D.; Nakhle, F.; Testolin, R.; Chiricao, M. V.; Santini, M.; Valentini, R.
10.1101/2024.01.24.576985 — ecology — Posted on 2025-03-15
2684 Super-omics and PCAS reveal tumor-like molecular landscape of rheumatoid arthritis
Xiao, L.; Aishan, N.; Ju, S.; Zhao, F.; Ouyang, X.; Chen, D.; Chen, W.; Xie, J.; Zhu, D.; Zhang, J.; Sun, L.; Li, Y.; Zhou, D.; Hu, Q.; Wu, J.; Meng, Q.; Zhou, J.; Xu, D.; Yu, J.; Liang, J.; Cai, Y.; Zhang, M.; He, Y.; Sun, Z.; Wang, L.; Lin, J.; Ji, F.
10.1101/2025.01.17.633562 — immunology — Posted on 2025-03-15
2686 Benchmarking AlphaFold3-like Methods for Protein-Peptide Complex Prediction
Zhou, F.; Guo, S.; Peng, X.; Zhang, S.; Men, C.; Duan, X.; Zhu, G.; Wang, Z.; Li, W.; Mu, Y.; Zheng, L.; Liu, H.; Wang, S.
10.1101/2025.03.09.642277 — bioinformatics — Posted on 2025-03-15
2687 MyoBack: A Musculoskeletal Model of the Human Back with Integrated Exoskeleton
Walia, R.; Garzon, K.; Billot, M.; Subramanian, S.; WANG, H.; Refai, M. I.; Durandau, G.
10.1101/2025.03.13.643057 — bioengineering — Posted on 2025-03-15
2688 Macrocyclic phage display for identification of selective protease substrates
Faucher, F. F.; Lovell, S.; Bertolini, M.; Blazkova, K.; Cosco, E. D.; Bogyo, M.; Barniol-Xicota, M.
10.1101/2025.03.13.643185 — biochemistry — Posted on 2025-03-15
2689 Mitochondrial DNA variation of the striped hyena (Hyaena hyaena) in Algeria and further insights into the species' evolutionary history
Derouiche, L.; Rodrigues, M.; Benameur-Hasnaoui, H.; Aissa, R. H.; Hassan-Beigi, Y.; Madjdzadeh, S. M.; Amr, Z.; Cokayne, A.; Vercammen, P.; Fernandes, C.
10.1101/2025.03.13.643148 — evolutionary biology — Posted on 2025-03-15
2693 Pseudogenization of the cntQ permease confers distinct yersinopine-metal uptake selectivity in Yersinia species
Laffont, C.; Pradel, E.; Ouerdane, L.; Brodel, A.; Gomez, N. O.; Hujeux, A.; Tribout, M.; Brutesco, C.; Voulhoux, R.; Lobinski, R.; Sebbane, F.; Arnoux, P.
10.1101/2025.03.14.643292 — microbiology — Posted on 2025-03-15
2694 Steering fatty acid composition of yeast microbial oil via genetic modification and bioprocess adjustment
Duman-Özdamar, Z. E.; Saccenti, E.; Martins dos Santos, V. A. P.; Hugenholtz, J.; Suarez-Diez, M.
10.1101/2025.03.14.643280 — microbiology — Posted on 2025-03-15
2695 C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC- Derived Microglia and Modulates Glial-Neuronal Crosstalk
Mearelli, M.; Hirschberg, I.; Provenzano, F.; Weissleder, C.; Rizzuti, M.; Ottoboni, L.; Corti, S.; Deleidi, M.
10.1101/2025.03.14.643263 — neuroscience — Posted on 2025-03-15
2696 Continuous FACS sorting of double emulsion picoreactors with a 3D printed vertical mixer.
Yang, Z.; Thompson, S.; Zhang, Y.; Rutten, I.; Van Duyse, J.; Van Isterdael, G.; Nichols, L.; Lammertyn, J.; Soh, H. T.; Fordyce, P. M.
10.1101/2025.03.13.643134 — bioengineering — Posted on 2025-03-15
2699 Nuances of floral mimicry in Queen of Sheba orchids
Scaccabarozzi, D.; Flematti, G.; Brundrett, M. C.; Vallejo-Marin, M.; Lunau, K.; Gagliano, M.; Pioltelli, E.; Houston, T.; Aromatisi, A.; Sletvold, N.
10.1101/2025.03.13.642682 — ecology — Posted on 2025-03-15
2701 Hierarchical assembly and functional resilience of the mammalian RNA exosome
Navalayeu, T.; Beer, N.; Bebjakova, M.; Kalis, R.; Stejskal, K.; Krssakova, G.; Fasching, N.; Herzog, V.; Popitsch, N.; Roitinger, E.; Zuber, J.; Ameres, S. L.
10.1101/2025.03.14.643291 — molecular biology — Posted on 2025-03-15
2702 Replication coordination marks the domestication of large extrachromosomal replicons in bacteria
Czarnecki, J.; Lamberioux, M.; Skovgaard, O.; Bignaud, A.; Taib, N.; Niault, T.; Bourhy, P.; Bos, J.; Krakowska, E.; Bartosik, D.; Koszul, R.; Marbouty, M.; Mazel, D.; Val, M.-E.
10.1101/2025.03.15.643453 — microbiology — Posted on 2025-03-15
2703 A SHERLOCK toolbox for the eco-epidemiological surveillance of animal African trypanosomosis reveals a similar parasite diversity in domestic pigs in two ancient sleeping sickness foci in Western Africa.
Eloiflin, R.-J.; Perez-Anton, E.; Camara, A.; Dujeancourt-Henry, A.; Boiro, S.; N Djetchi, M.; Traore, M.; Koffi, M.; Kaba, D.; Le Pennec, Y.; Doukoure, B.; Camara, A. D.; Kagbadouno, M.; Campagne, P.; Camara, M.; Jamonneau, V.; Thevenon, S.; Bart, J.-M.; Glover, L.; Rotureau, B.
10.1101/2025.03.14.643090 — microbiology — Posted on 2025-03-15
2704 Hydrogenase-driven ATP synthesis from air
Soom, S.; Moning, S. U.; Cook, G. M.; Lingford, J. P.; Kropp, A.; Tran, S.; Grinter, R.; Greening, C.; von Ballmoos, C.
10.1101/2025.03.14.643271 — microbiology — Posted on 2025-03-15
2705 The Neovaginal Microbiota, Symptoms, and Local Immune Correlates in Transfeminine Individuals with Penile Inversion Vaginoplasty
Rojas Vargas, J.; Wilcox, H.; Monari, B.; Gajer, P.; Zuanazzi, D.; Shouldice, A. C.; Parmar, R.; Haywood, P.; Tai, V.; Krakowsky, Y.; Potter, E.; Ravel, J.; Prodger, J.
10.1101/2025.03.14.643288 — microbiology — Posted on 2025-03-15
2706 Global Skeletal Muscle Metabolomics Reveals Mechanisms Behind Higher Response to Resistance Training in Older Adults
Lim, C.; Lixandrao, M.; Trivedi, D.; Xu, Y.; Prokopidis, K.; Roschel, H.; Phillips, S. M.; Muhamadali, H.; Isanejad, M.
10.1101/2025.03.13.642876 — systems biology — Posted on 2025-03-15
2711 Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition
Wang, Q.; Kong, X.; Song, H.; Wang, L.; Li, L.; Hou, X.; Renuse, S.; Cheng, R.; Khan, M. K. H.; Fang, L.; Lotan, T. L.; Park, B. H.; Weroha, S. J.; Zhou, H.; Pandey, A.; Wu, X.
10.1101/2025.03.13.643053 — cancer biology — Posted on 2025-03-15
2713 C9orf50 is a Targetable Spliceosome Regulator for Cancer Immunotherapy
Shao, T.; Chuanyang, L.; Kuang, J.; Xie, S.; Qu, Y.; Li, Y.; Liu, F.; Zhang, L.; Li, M.; Hou, T.; Qi, Y.; Wang, J.; Zhang, S.; Liu, Y.; Hu, Y.; Zhang, S.; Zhu, L.; Shao, J.-z.; Lin, A.; Wang, G.; Zhu, L.
10.1101/2025.03.13.642772 — cancer biology — Posted on 2025-03-15
2714 IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer.
Doultsinos, D.; Tomljanovic, I.; Pilalis, E.; Abusamra, S.; Parmentier, R.; Bridges, I. E.; Figiel, S.; Zekri, Y.; Hester, J.; Leach, D.; Bevan, C.; Lamb, A. D.; Zwart, W.; Chatziioannou, A.; Le Magnen, C.; Mills, I. G.
10.1101/2025.03.13.643042 — cancer biology — Posted on 2025-03-15
2715 Inducible estrogen receptor alpha in normal breast epithelial cells demonstrate estrogen receptor-dependent DNA damage
Majhi, P. D.; Black, A. L.; Sharma, A.; Phadkar, J.; Roberts, A. L.; Singh, P.; Kane, J. J.; O'Dare, K.; van Eijk, P.; Reed, S. H.; Schneider, S. S.; Jerry, D. J.
10.1101/2025.03.13.643100 — cancer biology — Posted on 2025-03-15
2716 Hyper-responsiveness of cancer stem cells to microenvironmental cues controls metastasis and therapy response through YAP/TAZ/TEAD
Tang, B.; Minin, J.; Gonzalez, V.; Khan, Z.; Raviv, Y.; Yang, Y.-a.; Carney, C.; Millman, Z.; Grun, D.; Pineda, C. M.; Sharma, A.; Esposito, D.; Yan, H.; Huang, J.; Tran, A. D.; Kruhlak, M.; Yang, H. H.; Lee, M. P.; Wakefield, L. M.
10.1101/2025.03.13.643008 — cancer biology — Posted on 2025-03-15
2717 Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy
Sabatino, V.; Fleisch, S.; Tang, C.; Muller, F. M.; Labao-Almeida, C.; Khaw, W. T.; Hogan, S.; Hicks, D. R.; Fontes, M.; Coelho, A. R.; Yang, W.; Sarkar, I.; Shome, D.; Vidal, A. V.; Cabeza-Cabrerizo, M.; Rohm, T.; Reijmers, R. M.; Kaymak, D.; Gerster, F.; Baker, D.; Fior, R.; Hutter, G.; Bernardes, G. J. L.
10.1101/2025.03.13.642658 — cancer biology — Posted on 2025-03-15
2718 A549 tumorigenic and BEAS-2B non-tumorigenic cell line derived small extracellular vesicles show distinct proteomic, N-glycoproteomic and chondroitin/dermatan sulfate profiles
Balbisi, M.; Lango, T.; Horvath, V. N.; Pal, D.; Schlosser, G.; Kecskemeti, G.; Szabo, Z.; Ilyes, K.; Nagy, N.; Toth, O.; Visnovitz, T.; Varga, Z.; G. Vertessy, B.; Turiak, L.
10.1101/2025.03.13.643059 — cancer biology — Posted on 2025-03-15
2719 Topoisomerase IIIb protects from tumorigenesis and immune dysregulation
Mahmud, M. R. A.; Baechler, S. A.; Dhall, A.; Saha, S.; Zhang, H.; Zhang, S.; Lee, M.-j.; Sato, N.; Rastogi, S.; Kumar, S.; Alam, M. S.; Saha, L. K.; Mock, B. A.; Factor, V. M.; Pommier, Y.
10.1101/2025.03.13.643061 — cancer biology — Posted on 2025-03-15
2722 Ligand-binding pockets in RNA, and where to find them
Veenbaas, S. D.; Koehn, J. T.; Irving, P. S.; Lama, N. N.; Weeks, K. M.
10.1101/2025.03.13.643147 — biophysics — Posted on 2025-03-15
2725 Bioenergetic metabolism restarts alongside germinant sensing and hydration in bacterial spore germination
Gupta, P.; Caldbeck, R.; Walters, R. C.; Wells, E. C.; Hardman, B. L.; Christie, G.; Springett, R. J.; Blaza, J. N.
10.1101/2025.03.13.642030 — biophysics — Posted on 2025-03-15
2734 Integration of polygenic risk with single cell methylation profiles for depression
Li, X.; Hou, K.; Eyring, K. W.; Liu, C.; Luo, C.; Geschwind, D. H.; Pasaniuc, B.
10.1101/2025.03.11.642615 — bioinformatics — Posted on 2025-03-15
2737 Intracortical Microstimulation Induces Rapid Microglia Process Convergence
Williams, N. P.; Kelly, A. M.; Zheng, X. S.; Vazquez, A. L.; Cui, X. T.
10.1101/2025.03.13.643075 — bioengineering — Posted on 2025-03-15
2738 A Microneedle Device for Rapid Dermal Interstitial Fluid Sampling
Hung, A. H.; Rajesh, N. U.; Bermudez, A.; Boczek, S. M.; Garcia-Marques, F. J.; Tan, Y. L.; Hwang, J.; Sinawang, P. D.; Ilyin, D.; Jacobson, G. B.; Demirci, U.; Poplack, S. P.; Pitteri, S. J.; DeSimone, J. M.
10.1101/2025.03.13.641882 — bioengineering — Posted on 2025-03-15
2739 BIOFABRICATION OF AN OVINE INTERVERTEBRAL DISC MODEL BY COMBINING A POLYCAPROLACTONE FRAME WITH A BIOPRINTED ALGINATE HYDROGEL
Carrot, E.; Chaaban, M.; Cano, D.; Schiex, C.; Veziers, J.; Halgand, B.; Loll, F.; Clouet, J.; Monaghan, M.; Fusellier, M.; Guicheux, J.; Delplace, V.; Le Visage, C.
10.1101/2025.03.13.642855 — bioengineering — Posted on 2025-03-15
2740 Airway smooth muscle--on-a-chip: a microfluidic approach to study alveolar smooth muscle remodelling
Suhail, A.; Xavier, J.; PK, H.; Krishnan MJ, A.; Pradeep, A.; KB, M.; S, R.; NS, R.; Bernardino de la Serna, J.
10.1101/2025.03.13.643111 — bioengineering — Posted on 2025-03-15
2741 Electrochemical Paper Fluidic Device for Extended Real-time Cocaine Monitoring in Simulated Sweat
Hoilett, O. S.; Foust, J.; Dave, N.; Balash, B.; Moryl, D.; Kumar, A.; Linnes, J. C.
10.1101/2025.03.13.643163 — biochemistry — Posted on 2025-03-15
2744 National Scale Genomic Engine for Precision Medicine: Singapore PRECISE-SG100K Experience
Bellis, C.; Kolle, G.; Yong, J.; Hebrard, M.; Bertin, N.; Lin, C.; Koh, J.; Cheng, P.; Sunmugam, S.; Heng, K. K.; Xie, Z.; Meah, W. Y.; Chen, X. Y.; Lim, E.; Alberts, R.; Lim, S.; Leong, S. H.; Ow, J. L.; Toro Jimenez, R.; Wong, E.; Tong, T.; Kerk, S. K.; Yao, J.; Chee, M. L.; PRECISE Genomic Engine Consortium, ; Yeo, K. K.; Cheng, C.-Y.; Sim, X.; Zheng, W.; Khor, C. C.; Tai, E. S.; Chambers, J. C.; Tan, P.
10.1101/2025.03.13.642552 — genomics — Posted on 2025-03-15
2745 A chromosome-level genome of the King penguin (Aptenodytes patagonicus): an emerging model-in-the-wild for studying evolution
Paris, J. R.; Fernandes, F. A. N.; Santos, C. A.; Pointon, D.-L. B.; Wood, J. M. D.; Obiol, J. F.; Salces-Oritz, J.; Fernandez, R.; Cristofari, R.; Le Bohec, C.; Trucchi, E.
10.1101/2025.03.13.642884 — genomics — Posted on 2025-03-15
2746 Using semantic search to find publicly available gene-expression datasets
Salmons, G.; Wengler, J.; Fabelico, A. J. S.; Muir, A.; Tubbs, A.; Warren, A.; Millett, A. N.; Yu, X. X.; Pavlidis, P.; Rogic, S.; Piccolo, S. R.
10.1101/2025.03.13.643153 — genomics — Posted on 2025-03-15
2747 Genome-wide analysis reveals the genetic basis of key agronomic traits and modern wheat breeding in Henan Province
Peng, C.; Chen, Y.; Han, X.; Dong, H.; Zheng, A.; Du, X.; Chang, X.; Zhao, M.; Qi, X.; Zhang, Y.; Hu, L.
10.1101/2025.03.13.642997 — genetics — Posted on 2025-03-15
2749 Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells
Hebert-Milette, I.; Levesque, C.; Paquette, J.; Rivard, M.-E.; Villeneuve, L.; Boucher, G.; Goyette, P.; Charron, G.; Rioux, J. D.
10.1101/2025.03.14.643205 — genetics — Posted on 2025-03-15
2750 Direct cell-to-cell transmission of retrotransposons
Voichek, M.; Bernhard, A.; Novatchkova, M.; Handler, D.; Möseneder, P.; Rafanel, B.; Duchek, P.; Senti, K.-A.; Brennecke, J.
10.1101/2025.03.14.642691 — genetics — Posted on 2025-03-15
2751 Trajectories of genetic correlations in populations under selection: from theory to a case-study
Cuyabano, B. C.; Motta, M. R.; Vandenplas, J.; Garcia, N. L.; Shokor, F.; Croiseau, P.; Boichard, D.; Aguerre, S.; Mattalia, S.
10.1101/2025.03.13.643026 — genetics — Posted on 2025-03-15
2753 Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito
Tennessen, J. A.; Brosula, R.; Chabanol, E.; Bickersmith, S.; Early, A. M.; Laws, M.; Kelley, K. A.; Grillet, M. E.; Gamboa, D.; Lucas, E. R.; Duchemin, J.-B.; Quinones, M. L.; Sallum, M. A. M.; Bergo, E. S.; Moreno, J. E.; Nagi, S. C.; Arisco, N. J.; Sooklall, M.; Niles-Robin, R.; Castro, M. C.; Cox, H.; Gendrin, M.; Conn, J. E.; Neafsey, D. E.
10.1101/2025.03.13.643102 — evolutionary biology — Posted on 2025-03-15
2754 Resolving the evolutionary history of bighorn sheep to inform future management
Jahner, J. P.; Parchman, T. L.; Matocq, M. D.; Cox, M.; Crowhurst, R. S.; Galland, L. M.; Burdo, S. M.; Buchalski, M. R.; Hallas, J. M.; Barbosa, S.; Coltman, D. W.; Deakin, S.; Ernest, H. B.; Stowell, S. M. L.; Miyasaki, H.; Monteith, K. L.; Roug, A.; Schwantje, H.; Spaan, R. S.; Stephenson, T. R.; Taylor, J.; Waits, L. P.; Wehausen, J. D.; Epps, C. W.
10.1101/2025.03.13.643091 — evolutionary biology — Posted on 2025-03-15
2758 Estimating rangeland fractional cover and canopy gap size class with Sentinel-2 imagery
Allred, B. W.; McCord, S. E.; Assal, T. J.; Bestelmeyer, B. T.; Boyd, C. S.; Brooks, A. C.; Cady, S. M.; Fuhlendorf, S. D.; Green, S. A.; Harrison, G. R.; Jensen, E. R.; Kachergis, E. J.; Mattilio, C. M.; Mealor, B. A.; Naugle, D. E.; O'Leary, D.; Olsoy, P. J.; Peirce, E. S.; Reinhardt, J. R.; Shriver, R. K.; Smith, J. T.; Tack, J. D.; Tanner, A. M.; Tanner, E. P.; Twidwell, D.; Webb, N. P.; Morford, S. L.
10.1101/2025.03.13.643073 — ecology — Posted on 2025-03-15
2763 PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expression
Sanjeev, M.; Woodward, L. A.; Schiff, M. L.; Patton, R. D.; Myers, S.; Paul, D.; Bundschuh, R.; Singh, G.
10.1101/2025.03.13.643037 — molecular biology — Posted on 2025-03-15
2764 Granzyme-targeting quenched activity-based probes for assessing tumor response to immunotherapy
Kazim, M.; Ganguly, A.; Malespini, S. M.; Thang, L.; Patel, N. L.; Kim, C.; Kalein, J. D.; Difilippantonio, S.; Yoo, E.
10.1101/2025.03.13.643086 — molecular biology — Posted on 2025-03-15
2765 Mesoscale proximity labeling to study macro changes to chromatin occupancy
Douglas, C. J.; Samowitz, P.; Tong, F.; Long, A.; Bradley, C. M.; Radnai, L.; MacMillan, D. W. C.; Miller, C. A.; Rumbaugh, G.; Seath, C. P.
10.1101/2025.03.13.643041 — molecular biology — Posted on 2025-03-15
2766 Spatial Transcriptomics and Single-Nucleus RNA Sequencing Reveal rAAV2- and rAAV9-Specific Transduction Signatures in the Mouse Liver
Amberg, B.; Koechl, F.; Kumpesa, N.; Prasad, M.; Bochner, F.; Hernandez-Obiols, M.; Otteneder, M. B.; Stalder, L.; Shaffo, F.; Nowrouzi, A.; Markusic, D.; Haegel, H.; Xicluna, R.; Sultan, M.; Jacobsen, B.; Rottenberg, S.; Valdeolivas Urbelz, A.; Schwalie, P. C.; Hahn, K.
10.1101/2025.03.13.643011 — molecular biology — Posted on 2025-03-15
2767 Tetraspanin positivity as a function of extracellular vesicle size measured by a modified immuno-TEM protocol
Fagundez, P.; Olivera, A.; Gololobova, O. O.; Li Calzi, M.; Cayota, A.; Witwer, K.; Mendez, E.; Tosar, J. P.
10.1101/2025.03.13.643132 — molecular biology — Posted on 2025-03-15
2770 Dissection of amino acid acquisition pathways in Borrelia burgdorferi uncovers unique physiological responses
Kataria, A.; Bohrnsen, E.; Schwarz, B.; Drecktrah, D.; Samuels, S.; Myers, L.; Carmody, A. B.; Groshong, A.
10.1101/2025.03.14.643351 — microbiology — Posted on 2025-03-15
2772 Enhancing role of nitrogen fixation in biogeochemical cycles of the Pacific Arctic
Shiozaki, T.; Fujiwara, A.; Watanabe, E.; Nishino, S.; Harada, N.; Makabe, A.
10.1101/2025.03.15.643424 — microbiology — Posted on 2025-03-15
2776 Structure and Activation Mechanism of a Lamassu Phage Defence System
Li, Y.; Adams, D. W.; Liu, H. W.; Shaw, S. J.; Uchikawa, E.; Jaskolska, M.; Stutzmann, S.; Righi, L.; Szczelkun, M. D.; Blokesch, M.; Gruber, S.
10.1101/2025.03.14.643221 — microbiology — Posted on 2025-03-15
2777 First-void urine and cervicovaginal brushes as sampling devices for vaginal microbiome studies: a proof-of-concept study
Pinedo-Bardales, M.; Van Caesbroeck, A.; Ahannach, S.; Bell, M.; Van Keer, S.; Teblick, L.; Erreygers, I.; Bakelants, S.; Van den Bosch, S.; Condori-Catachura, S.; Wittouck, S.; Vorsters, A.; Lebeer, S.
10.1101/2025.03.14.643287 — microbiology — Posted on 2025-03-15
2778 The vaginal microbiota, symptoms, and local immune correlates in transmasculine individuals using sustained testosterone therapy
Monari, B.; Wilcox, H.; Haywood, P.; Gajer, P.; Rojas-Vargas, J.; Zuanazzi, D.; Rutt, L.; Shouldice, A. C.; Parmar, R.; Waetjen, L. E.; Krakowsky, Y.; Potter, E.; Prodger, J.; Ravel, J.
10.1101/2025.03.14.643255 — microbiology — Posted on 2025-03-15
2780 Metagenomic analysis and keeping quality determination of stored pepper pastes
Fawole, A. O.; Ogungbemi, K.; Onipede, G. O.; Kolapo, A. L.; Okedara, E. O.
10.1101/2025.03.14.643245 — microbiology — Posted on 2025-03-15
2781 Mapping the loss of flagellar motility across the tree of life
Philip, J. S.; Grewal, S.; Scadden, J.; Puente Lelievre, C.; Matzke, N. J.; McNally, L.; Baker, M. A.
10.1101/2024.12.05.626484 — microbiology — Posted on 2025-03-15
2782 Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation
Matthaiou, E. I.; El-Hafeez, A. A. A.; Sharifi, H.; Chatterjee, P.; Zinter, M. S.; Johansson, P.; Dhillon, E.; Chiu, W.; Qian, J.; Shaller, B.; Chang, J.; Pasupneti, S.; Borges, C. H.; Enejder, A.; Dhillon, G.; Gaudilliere, B. L. J.; Fortwendel, J. M.; Vyas, J. M.; Hsu, J.
10.1101/2025.03.13.643092 — immunology — Posted on 2025-03-15
2783 Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance
Aristin Revilla, S.; Verheem, A.; Frederiks, C. L.; Kim, Y.; Chalkiadakis, T.; Viergever, B.; Gyorffy, B.; Mocholi, E.; Kranenburg, O.; Prekovic, S.; Coffer, P. J.
10.1101/2025.03.13.643028 — immunology — Posted on 2025-03-15
2784 Rational redesign of antigen binding domain improves in vivo efficacy of CD22-CAR T cells
DeGolier, K. R.; Walsh, Z. H.; Leach, L.; Brzezinski, C.; Novak, A.; Dimitrov, D.; Kohler, M. E.; Fry, T. J.
10.1101/2025.03.13.643183 — immunology — Posted on 2025-03-15
2785 Predictive Modeling of acute Graft-versus-Host-Disease using Machine Learning on Immune Cell and Cytokine Profiles at Engraftment
Mendiratta, M.; Pandey, P.; Pandey, S.; Rai, S.; Ganguly, S.; Sasi, A.; Gupta, R.; Malik, P. S.; Pramanik, R.; Kumar, S.; Nayak, B.; Mir, R. A.; Bakhshi, S.; Pushpam, D.; Aggarwal, M.; Gupta, A. K.; Dhawan, R.; Seth, T.; Mahapatra, M.; Sahoo, R. K.
10.1101/2025.03.13.642957 — immunology — Posted on 2025-03-15
2786 Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity
Netrakanti, P. R.; Chopra, Y.; Agarwal, R.; Rajeev, P.; Kedia, S.; Jose, M.; Nadkarni, S.; Nair, D.
10.1101/2025.03.14.641702 — neuroscience — Posted on 2025-03-15
2788 Proteomic Subtyping of Alzheimer's Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers
Bangs, M. C.; Gadhavi, J.; Carter, E. K.; Ping, L.; Duong, D. M.; Dammer, E. B.; Wu, F.; Shantaraman, A.; Fox, E. J.; Johnson, E. C. B.; Lah, J. J.; Levey, A. I.; Seyfried, N. T.
10.1101/2025.03.14.643332 — neuroscience — Posted on 2025-03-15
2790 Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish
Boulanger-Weill, J.; Kaempf, F.; Schalek, R. L.; Petkova, M.; Vohra, S. K.; Savaliya, J. H.; Wu, Y.; Schuhknecht, G. F. P.; Naumann, H.; Eberle, M.; Kirchberger, K. N.; Rencken, S.; Bianco, I. H.; Baum, D.; Bene, F. D.; Engert, F.; Lichtman, J. W.; Bahl, A.
10.1101/2025.03.14.643363 — neuroscience — Posted on 2025-03-15
2791 Vagal afferent activation induces a NREM-sleep-like state with brain-body cooling, but locus coeruleus activation
Cherrad, N.; Foustoukos, G.; Fernandez, L. M.; Osorio-Forero, A.; Emmenegger, Y.; Franken, P.; Luthi, A.
10.1101/2025.03.14.643122 — neuroscience — Posted on 2025-03-15
2796 Schwann cells modified to secrete MANF is a potential cellular therapy for peripheral nerve regeneration
Sivakumar, B.; Hammond, C.; Martinez, V.; Joseph, N.; John, J. V.; Kumar, A.; Krishnan, A.
10.1101/2025.03.14.642904 — neuroscience — Posted on 2025-03-15
2803 HIPPIE: A Multimodal Deep Learning Model for Electrophysiological Classification of Neurons
Gonzalez-Ferrer, J.; Lehrer, J.; Schweiger, H. E.; Geng, J.; Hernandez, S.; Reyes, F.; Sevetson, J. L.; Salama, S.; Teodorescu, M.; Haussler, D.; Mostajo-Radji, M. A.
10.1101/2025.03.14.642461 — neuroscience — Posted on 2025-03-15
2805 Cell-Type-Specific Surfaceome Profiling of 100-500 Isolated Cells using a Droplet-Based Magnetic Affinity Purification System
Lorentzian, A. C.; Bartleson, J. M.; Ho, T.; Yang, Z.; Choi, M.; Cheung, T. K.; Rose, C. M.; Yewdell, W. T.; Zhu, Y.
10.1101/2025.03.13.643164 — systems biology — Posted on 2025-03-15
2806 Aerobicity stimulon in Escherichia coli revealed using multi-scale computational systems biology of adapted respiratory variants
Patel, A.; Banwani, N.; Mink, R.; Prabhakaran, D. M.; Khairnar, S. V.; Feist, A. M.; Palsson, B. O.; Anand, A.
10.1101/2025.03.13.642450 — systems biology — Posted on 2025-03-15
2809 High-resolution transcriptomic profiling of the aortic cellular landscape during hypertension reveals novel drivers of vascular fibrosis
Jelinic, M.; Dona, M. S.; Hughes, T. A. G.; Farrugia, G.; Harper, R.; Hsu, I.; Haslem, A.; Tran, V.; Galvao, H. B. F.; Diep, H.; Dinh, Q. N.; Gaynor, T.; Guzik, T. J.; Lemoli, M.; Sobey, C. G.; Bobik, A.; Lewsey, M. G.; Pinto, A. R.; Vinh, A.; Drummond, G. R.
10.1101/2025.03.13.642936 — physiology — Posted on 2025-03-15
2811 Suspension physics govern the multiscale dynamics of blood flow in sickle cell disease
Szafraniec, H. M.; Bull, F.; Higgins, J. M.; Stone, H. A.; Krueger, T.; Pearce, P.; Wood, D. K.
10.1101/2025.03.13.642599 — physiology — Posted on 2025-03-15
2812 Vasopressin-Dependent β-Catenin Phosphorylation at Ser552 and Branching Structure of Mouse Collecting Duct System
Ou, S.-M.; Kikuchi, H.; Park, E.; Yang, C.-R.; Raghuram, V.; Khan, S.; Murillo-de-Ozores, A. R.; Chen, L.; Chou, C.-L.; Knepper, M.
10.1101/2025.03.13.643123 — physiology — Posted on 2025-03-15
2813 Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy
LAI, H.-T.; Dias-Pedroso, D.; Marques Da Costa, M. E.; Fernandes, R.; Nguyen, T. N. A.; Bawa, O.; Khneisser, P.; Dokudovskaya, S.; Kroemer, G.; Marchais, A.; Gaspar, N.; Geoerger, B.; Diane, O.; Mazzanti, L.; Ha Duong, T.; Lewin, G.; Ferrie, L.; Figadere, B.; Brenner, C.
10.1101/2025.03.13.642976 — pharmacology and toxicology — Posted on 2025-03-15
2814 Role of Long Chain Acyl-CoA Synthetases in MASH-driven Hepatocellular Carcinoma and Ferroptosis
Classon, P.; Wixom, A.; Mancipe, N. C.; Graham, R. P.; Tran, N.; Taner, T.; Povero, D.
10.1101/2025.03.13.642692 — pathology — Posted on 2025-03-15
2816 AI, citizen science, and the 2024 eclipse emphasize the importance of light for bird behavior
Aguilar, L. A.; Miller-Crews, I.; Dobris, J. M.; Tracy, J. A.; Macklin, P.; Dixit, S.; Jacobson, R. A.; Evans, R. L.; McGuire, E. L.; Beverly, D. P.; Reichard, D. G.; Rosvall, K. A.
10.1101/2025.03.14.643188 — animal behavior and cognition — Posted on 2025-03-15
2818 Ontogeny of the spinal cord dorsal horn
Roome, R. B.; Yadav, A.; Flores, L.; Puarr, A.; Nardini, D.; Richardson, A.; Waclaw, R. R.; Arkell, R. M.; Menon, V.; Johnson, J. E.; Levine, A.
10.1101/2025.03.14.643370 — neuroscience — Posted on 2025-03-15
2819 Co-Activation Patterns in Neonates using High-Density Diffuse Optical Tomography: Insights into Early Dynamic Functional Connectivity
Lee, K. E.; Austin, T.; Uchitel, J.; Caballero Gaudes, C.; Collins-Jones, L. H.; Cooper, R.; Edwards, A.; Hebden, J.; Kromm, G.; Pammenter, K.; Blanco, B.
10.1101/2025.03.15.643385 — neuroscience — Posted on 2025-03-15
2820 A FMRF-amide peptide that regulates cell non-autonomous protein homeostasis in C. elegans.
Sheeler, C. A.; Lo, J. Y.; Menendez Escalera, D.; Griffin-Baldwin, E.; Mah, K.; Roszczyk, A.; Roux, A. E.; Kenyon, C.; Garrison, J. L.; Frakes, A. E.
10.1101/2025.03.14.643343 — neuroscience — Posted on 2025-03-15
2823 Membrane-permeable 5-fluorodeoxyuridine triphosphate derivatives inhibit the proliferation of Plasmodium falciparum
Nikolova, V.; Linnemannstoens, K.; Bendel, M.-E.; Machado, M.; Ganter, B.; Budimir, P.; Vogts, M.; Ganter, M.; Meier, C.; Dobbelstein, M.
10.1101/2025.02.25.640175 — microbiology — Posted on 2025-03-15
2824 Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
Yabaji, S. M.; Zhernovkov, V.; Araveti, P. B.; Lata, S.; Rukhlenko, O. S.; Abdullatif, S. A.; Vanvalkenburg, A.; Alekseev, Y.; Ma, Q.; Dayama, G.; Lau, N. C.; Johnson, W. E.; Bishai, W. R.; Crossland, N. A.; Campbell, J. D.; Kholodenko, B. N.; Gimelbrant, A. A.; Kobzik, L.; Kramnik, I.
10.1101/2024.03.05.583602 — immunology — Posted on 2025-03-15
2826 Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome.
Wang, H.-B.; Smale, N. E.; Brown, S. H.; Villanueva, S. A.; Zhou, D.; Mulji, A.; Bhandal, D. S.; Nguyen-Ngo, K.; Harvey, J. R.; Ghiani, C. A.; Colwell, C. S.
10.1101/2024.09.16.613343 — neuroscience — Posted on 2025-03-15
2827 Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas.
Jain, N.; Ogbonna, E. C.; Maliga, Z.; Jacobson, C. A.; Zhang, L.; Shih, A. R.; Rosenberg, J. M.; Kalam, H.; Gagne, A.; Solomon, I. H.; Santagata, S.; Sorger, P. K.; Aldridge, B. B.; Martinot, A. J.
10.1101/2025.03.10.642376 — pathology — Posted on 2025-03-15
2828 Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits
Koh, M.; Anselmi, F.; Kaushalya, S. K.; Hernandez, D. E.; Bast, W. G.; Villar, P. S.; Chae, H.; Davis, M. B.; Teja, S. S.; Qu, Z.; Gradinaru, V.; Gupta, P.; Banerjee, A.; Albeanu, D. F.
10.1101/2025.02.24.639992 — neuroscience — Posted on 2025-03-15
2829 Dopamine and calcium dynamics in the nucleus accumbens core during food seeking
Weber, S. J.; Driscoll, G. S.; Beutler, M. M.; Kuhn, H. M.; Westlake, J. G.; Wolf, M. E.
10.1101/2025.03.11.642710 — neuroscience — Posted on 2025-03-15
2830 Alternatives to Friction Coefficient: Role of Frictional Instabilities on Fine Touch Perception
Derkaloustian, M.; Bhattacharyya, P.; Ngo, T. T.; Cashaback, J.; Medina, J.; Dhong, C. B.
10.1101/2024.10.25.620351 — neuroscience — Posted on 2025-03-15
2836 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-03-15
2838 Uncovering the Emergent Robustness and Treadmilling in a Cell-Mimicking Actin Cortex: Mechanistic insights from basic components
Gat, S.; Amit, Y.; Livne, G.; Sanchez, D. S.; Porat, N.; Yochelis, A.; Gov, N.; Bernheim-Groswasser, A.
10.1101/2024.11.04.621887 — biophysics — Posted on 2025-03-15
2839 Unveiling Tissue Structure and Tumor Microenvironment from Spatial Omics by Hypergraph Learning
Liao, Y.; Zhang, C.; Wang, Z.; Qi, F.; Huang, W.; Cai, S.; Li, J.; Yuan, Z.; Song, J.; Cai, H.
10.1101/2024.05.15.594168 — bioinformatics — Posted on 2025-03-15
2841 Lab-in-the-loop therapeutic antibody design with deep learning
Frey, N. C.; Hotzel, I.; Stanton, S. D.; Kelly, R. L.; Alberstein, R. G.; Makowski, E. K.; Martinkus, K.; Berenberg, D.; Bevers, J.; Bryson, T.; Chan, P.; Czubaty, A.; D'Souza, T. A.; Dwyer, H.; Dziewulska, A.; Fairman, J. W.; Goodman, A.; Hofmann, J. L.; Isaacson, H. H.; Ismail, A. A.; James, S.; Joren, T.; Kelow, S. P.; Kiefer, J. R.; Kirchmeyer, M.; Kleinhenz, J.; Koerber, J. T.; Lafrance-Vanasse, J.; Leaver-Fay, A.; Lee, J. H.; Lee, E.; Lee, D. W.; Liang, W.-C.; Lin, J. Y.-Y.; Lisanza, S.; Loukas, A.; Ludwiczak, J.; Mahajan, S. P.; Mahmood, O.; MohammadiPeyhani, H.; Nerli, S.; Park, J. W.;
10.1101/2025.02.19.639050 — bioengineering — Posted on 2025-03-15
2843 Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology
Kokoris, M.; McRuer, R.; Nabavi, M.; Jacobs, A.; Prindle, M.; Cech, C.; Berg, K.; Lehmann, T.; Machacek, C.; Tabone, J.; Chandrasekar, J.; McGee, L.; Lopez, M.; Reid, T.; Williams, C.; Barrett, S.; Lehmann, A.; Kovarik, M.; Busam, R.; Miller, S.; Banasik, B.; Kesic, B.; Arryman, A.; Rogers-Peckham, M.; Kimura, A.; LeProwse, M.; Wolfin, M.; Kritzer, S.; Leadbetter, J.; Babazedeh, M.; Chase, J.; Thiessen, G.; Lint, W.; Goodman, D.; O'Connell, D.; Lumanpauw, N.; Hoffman, J.; Vellucci, S.; Collins, K.; Vellucci, J.; Taylor, A.; Murphy, M.; Lee, M.; Corning, M.
10.1101/2025.02.19.639056 — genomics — Posted on 2025-03-15
2844 Simultaneous measurement of intrinsic promoter and enhancer potential reveals principles of functional duality and regulatory reciprocity
Paramo, M. I.; Leung, A. K.-Y.; Shah, S. R.; Zhang, J.; Tippens, N. D.; Liang, J.; Yao, L.; Jin, Y.; Pan, X.; Ozer, A.; Lis, J. T.; Yu, H.
10.1101/2025.03.14.643265 — genomics — Posted on 2025-03-15
2845 Secreted exosomes induce filopodia formation
McAtee, C.; Patel, M. R.; Hoshino, D.; Sung, B. H.; von Lersner, A. K.; Shi, M.; Hong, N. H.; Young, A.; Krystofiak, E.; Zijlstra, A.; Weaver, A. M.
10.1101/2024.07.20.604139 — cell biology — Posted on 2025-03-15
2847 A transcriptional atlas of the pubertal human growth plate reveals direct stimulation of cartilage stem cells by growth hormone.
Chu, N. T. L.; Dregval, O.; Zaman, F.; Li, L.; Tian, X.; Liu, X.; Trompet, D.; Zhou, B.; Heinonen, J. O.; Ohlsson, C.; Savendahl, L.; Adameyko, I.; Chagin, A. S.
10.1101/2025.03.14.642964 — cell biology — Posted on 2025-03-15
2848 Vaginal microbiota as a predictor of preterm birth: an observational cohort study in a high-risk population
Lesimple, L.; Rousseau, J.; Plainvert, C.; Landraud, L.; Grall, N.; Goffinet, F.; Ancel, P.-Y.; Pannetier, C.; Poyart, C.; Mandelbrot, L.; Tazi, A.
10.1101/2024.09.11.612423 — microbiology — Posted on 2025-03-15
2849 Two-Stage CD8+ CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma
Cao, G.; Hu, Y.; Pan, T.; Tang, E.; Asby, N.; Althaus, T.; Wan, J.; Riedell, P.; Bishop, M.; Kline, J.; Huang, J.
10.1101/2025.03.05.641715 — immunology — Posted on 2025-03-15
2851 Synthetic torpor in the rat recapitulates key features of natural torpor and is cardioprotective
Elley, M.; Taddei, L.; Khan, M. A.; Wilcox, U. R.; Hitrec, T.; Pickering, A. E.; Ambler, M.
10.1101/2025.03.12.642790 — neuroscience — Posted on 2025-03-15
2852 Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves
Sammons, R. P.; Masserini, S.; Velasquez, L. M.; Metodieva, V. D.; Cano, G.; Sannio, A.; Orlando, M.; Maier, N.; Kempter, R.; Schmitz, D.
10.1101/2024.04.16.589773 — neuroscience — Posted on 2025-03-15
2853 Sequence action representations contextualize during early skill learning
Dash, D.; Iwane, F.; Hayward, W.; Salamanca-Giron, R.; Bonstrup, M.; Buch, E.; Cohen, L.
10.1101/2024.08.15.608189 — neuroscience — Posted on 2025-03-15
2859 A morphology and secretome map of pyroptosis
Lippincott, M. J.; Tomkinson, J.; Bunten, D.; Mohammadi, M.; Kastl, J.; Knop, J.; Schwandner, R.; Huang, J.; Ongo, G.; Robichaud, N.; Dagher, M.; Mansilla-Soto, A.; Saravia-Estrada, C.; Tsuboi, M.; Basualto-Alarcon, C.; Way, G. P.
10.1101/2024.04.26.591386 — systems biology — Posted on 2025-03-15
2861 niiv: Interactive Self-supervised Neural Implicit Isotropic Volume Reconstruction
Troidl, J.; Liang, Y.; Beyer, J.; Tavakoli, M.; Danzl, J. G.; Hadwiger, M.; Pfister, H.; Tompkin, J.
10.1101/2024.09.07.611785 — bioinformatics — Posted on 2025-03-15
2865 Proteomic and structural comparison between cilia from primary ciliary dyskinesia patients with a DNAH5 defect
de Ceuninck van Capelle, C.; Luo, L.; Leitner, A.; Tschanz, S.; Latzin, P.; Ott, s.; herren, t.; Mueller, L.; Ishikawa, T.
10.1101/2025.03.14.643267 — cell biology — Posted on 2025-03-15
2869 Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9
Jeong, H.-K.; Gonzalez-Fernandez, E.; Crawley, I.; Coakley, J. M.; Hwang, J.; Martin, D. D. O.; Bamji, S. X.; KIM, J.-I.; Kang, S.-H.; Thomas, G.
10.1101/2023.09.19.558291 — neuroscience — Posted on 2025-03-15
2871 ZIP editors for efficient and versatile CRISPR-Cas9 precise genome editing
Thibault, C.; Rosier, J.; Riandiere, M.; Marin, V.; Fayet, S.; Berges, C.; Espasa, R.; Lamrissi-Garcia, I.; Trian, T.; Bui, S.; Dabernat, S.; Boutin, J.; Moreau-Gaudry, F.; Bedel, A.
10.1101/2025.03.13.642982 — bioengineering — Posted on 2025-03-15
2872 Nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs
Jian, X.; Zhao, J.; Marschall, E. M.; Roberts, D. M.; Cryle, M. J.; Alkhalaf, L. M.; Challis, G.
10.1101/2025.03.13.642940 — biochemistry — Posted on 2025-03-14
2873 Mechanistic Basis for Inhibition of the Extended Spectrum Class A b-Lactamase GES-1 by Tazobactam and Enmetazobactam
Beer, M.; Hinchliffe, P.; Hanzevacki, M.; Bethel, C. R.; Tooke, C. L.; van der Kamp, M. W.; Papp-Wallace, K. M.; Bonomo, R. A.; Shapiro, S.; Mulholland, A. J.; Spencer, J.
10.1101/2025.03.13.642993 — biochemistry — Posted on 2025-03-15
2874 Cell type-specific intronic RNAs shape genome architecture during neuronal lineage specification
Kang, W.; Yip, W. H.; Verron, Q.; Bouwman, B. A. M.; Li-Wang, X.; Abou Yaghi, A.; Murata, M.; Stout, M.; Salviati, L.; Shu, X.; Yasuzawa, K.; Gaviraghi, M.; Pracana, R.; Lord, J.; Ballarino, R.; Falk, A.; W. Shin, J.; Kasukawa, T.; Yip, C.; Kato, M.; Takahashi, H.; Crosetto, N.; Carninci, P.; Bienko, M.
10.1101/2025.03.13.641826 — genomics — Posted on 2025-03-14
2877 Fecal microbiota transplantation mitigates cardiac remodeling and functional impairment in mice with chronic colitis
Li, Q.; Zhong, X. S.; Lopez, K. M.; Krishnachaitanya, S. S.; Liu, M.; Xiao, Y.; Ou, R.; Nagy, H. I.; Kochkarian, T.; Powell, D. W.; Fujise, K.
10.1101/2025.03.13.643179 — cell biology — Posted on 2025-03-15
2878 Chromatin organization controls nuclear stiffness
Romero, H.; Amiri, A.; Pabba, M. K.; Zhang, H.; Berg, V.; Arroyo, M.; Prorok, P.; Trautwein, N.; Laube, B.; Dietz, C.; Cardoso, M. C.
10.1101/2025.03.14.643219 — cell biology — Posted on 2025-03-15
2880 PHF19 drives PRC2 sub-nuclear compartmentalization to promote motility in TNBC cells
Pelzer, N.; Lukic, T.; Ge, W.; Schnabel, N.; Teufel, P.; Olayioye, M. A.; Najafova, Z.; Lungu, C.
10.1101/2025.03.13.642950 — molecular biology — Posted on 2025-03-14
2882 Tuning antibody stability and function by rational designs of framework mutations
Ng, J. C.; Chenoweth, A.; De Sciscio, M. L.; Grandits, M.; Cheung, A.; Chu, T.; McCraw, A.; Chauhan, J.; Liu, Y.; Guo, D.; Patel, S.; Kosmider, A.; Iancu, D.; Karagiannis, S. K.; Fraternali, F.
10.1101/2025.03.13.642419 — immunology — Posted on 2025-03-15
2885 Design of solubly expressed miniaturized SMART MHCs
White, W. L.; Bai, H.; Kim, C. J.; Jude, K. M.; Sun, R.; Guerrero, L.; Han, X.; Chen, X. T.; Chaudhuri, A.; Bonzanini, J. E.; Sun, Y.; Onwuka, A. E.; Wang, N.; Wang, C.; Li, X.; Goreshnik, I.; Allen, A.; Levine, P. M.; Kueh, H. Y.; Jewett, M. C.; Sgourakis, N.; Achour, A.; Garcia, K. C.; Baker, D.
10.1101/2025.03.14.643101 — biochemistry — Posted on 2025-03-14
2890 Methods for Processing and Analyzing Images of Vascularized Micro-Organ and Tumor Systems
Hachey, S. J.; Hatch, C. J.; Gaebler, D.; Forsythe, A. G.; Ewald, M. L.; Chopra, A. L.; Fang, J. S.; Hughes, C. C. W.
10.1101/2025.03.12.642741 — bioengineering — Posted on 2025-03-14
2891 Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis
Passmore, M.; Jian, X.; de los Santos, E. L. C.; Roberts, D. M.; Lewandowski, J. R.; Jenner, M.; Alkhalaf, L. M.; Challis, G.
10.1101/2025.03.13.642309 — biochemistry — Posted on 2025-03-14
2893 Parasite virulence in coinfected hosts: the importance of infection order
Sorci, G.; Dusuel, A.; Bourbon, L.; Groetz, E.; Pernet, N.; Rialland, M.; Roche, B.; Faivre, B.
10.1101/2025.03.13.642968 — evolutionary biology — Posted on 2025-03-14
2897 Targeting Galectin-3 to modulate inflammation in LAMA2-deficient congenital muscular dystrophy
De Menezes, Y. K. T.; Lee, J.; Cheng-Zhang, J. Q.; Johnson, M. A.; Ranatunga, R. N.; Kemaladewi, D. U.
10.1101/2025.03.12.642905 — immunology — Posted on 2025-03-14
2898 Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-class antibodies
Agrawal, P.; Khechaduri, A.; Salladay, K. R.; MacCamy, A.; Ralph, D. K.; Riker, A.; Stuart, A. B.; Siddaramaiah, L. K.; Shen, X.; Matsen, F. A.; Montefiori, D.; Stamatatos, L.
10.1101/2025.03.13.642975 — immunology — Posted on 2025-03-14
2901 Engineering Conjugative Plasmids for Inducible Horizontal DNA Transfer
Jaafar, T.; Carvalhais, E.; Shrestha, A.; Cochrane, R.; Meaney, J.; Brumwell, S. L.; Hamadache, S.; Nasrollahi, V.; Karas, B. J.
10.1101/2025.03.12.642913 — synthetic biology — Posted on 2025-03-14
2902 Muscle-specific increased expression of JAG1 improves skeletal muscle phenotype in dystrophin-deficient mice.
de Souza Leite, F.; Lambert, M. R.; Zhang, T. Y.; Conner, J. R.; Paulo, J. A.; Oliveira, S. F.; Thakurta, S.; Bowles, J.; Gussoni, E.; Gygi, S. P.; Widrick, J. J.; Kunkel, L. M.
10.1101/2025.03.12.642857 — physiology — Posted on 2025-03-14
2903 Hypericum triquetrifolium Essential Oil: Chemical Composition, Hierarchical Cluster Analysis, and Antibacterial Activity
El-Elimat, T.; El-Qaderi, H. S.; Hudaib, M.; Al Sharie, A. H.; Alekish, M. O.; Al-Gharaibeh, M.; Hananeh, W. M.
10.1101/2025.03.12.642897 — pharmacology and toxicology — Posted on 2025-03-14
2905 Structural, biophysical and biological analysis and characterisation of IRF4 DNA-binding domain mutations associated with multiple myeloma
Tatum, N. J.; Scott, R.; Doody, G.; Hickson, I.; Jennings, C. E.; Martin, M. P.; Tooze, R.; Tucker, J. A.; Wittner, A.; Wang, L.-Z.; Wright, E. K.; Wedge, S. R.; Noble, M. E. M.
10.1101/2025.03.12.642038 — biophysics — Posted on 2025-03-14
2906 A nutrient bottleneck limits antibiotic efficacy in structured bacterial populations
Hancock, A. M.; Dill-Macky, A. S.; Moore, J. A.; Day, C.; Donia, M. S.; Datta, S. S.
10.1101/2025.03.12.642894 — biophysics — Posted on 2025-03-14
2907 SMART: an approach for accurate formula assignment in spatially-resolved metabolomics
Cao, Y.; Li, S.; Liu, Z.; Jia, Z.; Zhuang, W.; Pan, X.; Zhou, J.; Yang, L.; Wang, L.
10.1101/2025.03.12.642824 — bioinformatics — Posted on 2025-03-14
2909 Sensitive Transcriptomics and Genotyping reveals function of genetic variants in immunity
Liu, K.; Rasmussen, A.; Han, W.; Gong, Q.; Bohley, S.; Chen, D.; Kanai, M.; Maronick, R.; Yin, Z.; Hu, C.; Jain, T.; Martin-Rufino, J. D.; Sankaran, V. G.; Ashenberg, O.; Daly, M. J.; Chen, F.; Graham, D. B.; Xavier, R. J.
10.1101/2025.03.12.642879 — genomics — Posted on 2025-03-14
2910 Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR
Mabin, J. W.; Vock, I. W.; Machyna, M.; Haque, N.; Thakran, P.; Zhang, A.; Rai, G.; Leibler, I. N.-M.; Inglese, J.; Simon, M. D.; Hogg, J. R.
10.1101/2025.03.12.642874 — molecular biology — Posted on 2025-03-14
2911 When a chaotropic agent turns into a nutrient: Deciphering the assimilation of guanidine and its utilization to drive synthetic processes in cyanobacteria
Itzenhaeuser, M. A.; Enkerlin, A. M.; Dewald, J. A.; Stauder, R.; Halpick, H.; Schaale, R.; Baumann, L. M.; Selim, K. A.; Weinberg, C. E.; Klaehn, S.
10.1101/2025.03.14.643060 — microbiology — Posted on 2025-03-14
2915 Deletion of RSK2 kinase alleviates age-dependent hypertension
Somlyo, A. V.; Ayon, R. J.; Wang, Y. T.; Kalra, J. K.; Jin, L.; Chen, Y. L.; Polanowska-Grabowska, R.; Sonkusare, S. K.; Christie, C. K.; Small, E. M.; Le, T. H.
10.1101/2025.03.12.642932 — physiology — Posted on 2025-03-14
2917 Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence
Piyadasa, H.; Oberlton, B.; Ribi, M.; Ranek, J. S.; Averbukh, I.; Leow, K.; Amouzgar, M.; Liu, C. C.; Greenwald, N. F.; McCaffrey, E. F.; Kumar, R.; Ferrian, S.; Tsai, A. G.; Filiz, F.; Fullaway, C. C.; Bosse, M.; Varra, S. R.; Kong, A.; Sowers, C.; Gephart, M. H.; Nunez-Perez, P.; Yang, E.; Travers, M.; Schachter, M. J.; Liang, S.; Santi, M. R.; Bucktrout, S.; Gherardini, P. F.; Cole, K.; Barish, M. E.; Brown, C. E.; Oldridge, D. A.; Drake, R. R.; Phillips, J. J.; Okada, H.; Prins, R.; Bendall, S. C.; Angelo, M.
10.1101/2025.03.12.642624 — cancer biology — Posted on 2025-03-14
2918 Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor
Marks, D.; Garcia Castano, E.; Kumar, S.; Tyson, K.; Koch, C.; Ivanov, A.; Edel, J. B.; Mirza, H. B.; Flanagan, W.; Dunsby, C.; French, P. M. W.; McNeish, I. A.
10.1101/2025.03.12.642798 — cancer biology — Posted on 2025-03-14
2919 Dynamic Tracking and Single-Cell Analysis of Starvation-Induced Autophagic Responses in Breast Cancer Cells
Posligua Garcia, J. D.; Banqueri Pegalajar, M. d. C.; Richard Perkins, J.; Rodriguez Caso, C.; Urdiales Ruiz, J. L.; Ranea, J. A. A.; Medina, M. A.; Bernal, M.
10.1101/2025.03.12.642827 — cancer biology — Posted on 2025-03-14
2920 Loss of Gαq reshapes key fibroblast traits and drives matrix remodeling and aggressive progression of oral cancer tumors
Navarro-Lerida, I.; Huertas-Larez, R.; Paredes-Garcia, G.; Garcia-Mateos, D.; Jimenez-Lopez, M. I.; Lopez, J. A.; del Pozo, M. A.; Alvarez-Teijeiro, S.; Prieto-Fernandez, L.; Garcia-Pedrero, J. M.; Mayor, F.; Ribas, C.
10.1101/2025.03.12.642811 — cancer biology — Posted on 2025-03-14
2929 Interstitial fluid transport dynamics predict glioblastoma invasion and progression
Carman-Esparza, C. M.; Stine, C. A.; Atay, N.; Kingsmore, K. M.; Wang, M.; Woodall, R. T.; Rockne, R. C.; Cunningham, J. J.; Munson, J. M.
10.1101/2025.03.12.642840 — bioengineering — Posted on 2025-03-14
2930 High-Density Multi-Distance fNIRS Enhances Detection of Brain Activity during a Word-Color Stroop Task
Anderson, J. E.; Carlton, L.; Kura, S.; O'Brien, W. J.; Rogers, D.; Hajirahimi, P.; Farzam, P.; Zaman, M. H.; Boas, D. A.; Yucel, M. A.
10.1101/2025.03.12.642917 — bioengineering — Posted on 2025-03-14
2932 The Genome of the American Dog Tick (Dermacentor variabilis)
Cassens, J.; Villalta, M.; Aguirre, S.; Ecklund, L.; Stenger, T.; Abdi, I.; Venigalla, S.; Shiffman, E.; Bastug, K.; Thielen, B. K.; Faulk, C.
10.1101/2025.03.12.642860 — genomics — Posted on 2025-03-14
2936 Heat tolerance of tropical herbaceous plants increases with elevation
Hernandez, G. G.; Seemann, J. R.; Godoy, L. d. C.; Slot, M.; Garcia-Robledo, C.
10.1101/2025.03.12.642681 — ecology — Posted on 2025-03-14
2938 Development and Characterization of Chicken Lung Organoids for Future In Vitro Modeling of Avian Influenza Virus-Host Cell Interaction
Nicholson, H.; Zdyrski, C.; Corbett, M. P.; Lowen, A. C.; Catucci, M.; Melvin, B. J.; Stabler, L. J.; Douglass, E.; Mochel, J. P.; Allenspach, K.; Carnaccini, S.
10.1101/2025.03.12.640685 — cell biology — Posted on 2025-03-14
2941 Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation
Schnabel, L.; Osorio-Valeriano, M.; Perez-Borrajero, C.; Steinchen, W.; Mais, C.-N.; Simon, B.; Hanssmann, J.; Thamm, M.; Hennig, J.; Bange, G.; Thanbichler, M.
10.1101/2025.03.14.642875 — microbiology — Posted on 2025-03-14
2942 Low-salinity medium for large-scale biomass production of the marine purple photosynthetic bacterium Rhodovulum sulfidophilum
Morey-Yagi, S. R.; Hanh, D. D.; Suzuki, M.; Kato, S.; Liou, G.; Kuroishikawa, Y.; Yamaguchi, A.; Morishita, H.; Odahara, M.; Numata, K.
10.1101/2025.03.14.643199 — microbiology — Posted on 2025-03-14
2944 Bacteriophage protein Dap2 inhibits bacterial type III secretion system and synergizes with Dap1 to evade anti-phage immunity
Liang, H.; Zhao, J.; Zhu, Y.; Wang, C.; Tian, F.; Deng, J.; Liao, J.; Zhong, Z.; Liu, J.; Guo, N.; Le, S.
10.1101/2025.03.13.642734 — microbiology — Posted on 2025-03-14
2945 Diversity and predation capacities of Amoebozoa against opportunistic vibrios in contrasting Mediterranean coastal environments.
Robino, E.; Perret, A.; Noel, C.; Haffner, P.; Intertaglia, L.; Richard, M.; Descamps, N.; Sellier, A.; Onillon, L.; Lebaron, P.; Destoumieux-Garzon, D.; Charriere, G. M.
10.1101/2025.03.14.643055 — microbiology — Posted on 2025-03-14
2946 Intranasal AAV Vaccination of SARS-CoV-2 Induce Strong and Sustained Neutralizing Antibodies in Mice
Ji, Y.; Di Pasquale, G.; Zheng, C.; Afione, S.; Esperanza, T.; Yin, H.; Burbelo, P. D.; Chiorini, J. A.
10.1101/2025.03.14.640671 — immunology — Posted on 2025-03-14
2949 Targeted delivery of RNA-based therapeutics enables functional analysis of macrophage subpopulations
Rasmussen, R. K.; Gudbergsson, J. M.; Mathiesen, H.; Strauss, L. M.; Moller, I. H.; Thomsen, M. B.; Kristensen, M. W.; Andersen, M. N.; Etzerodt, A.
10.1101/2025.03.12.642907 — immunology — Posted on 2025-03-14
2950 Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow onThe Endothelial Cell Transcriptome
Meecham, A.; McCurdy, S.; Frias-Anaya, E.; Li, W.; Gallego-Gutierrez, H.; Ngyuen, P.; Yi-Shuan Li, J.; Chien, S.; Shyy, J. Y.-J.; Ginsberg, M.; Lopez-Ramirez, M. A.
10.1101/2025.03.12.642862 — pathology — Posted on 2025-03-14
2953 Endothelial Cept1 Promotes Post-Ischemic Angiogenesis in a Pparα-Dependent Fashion
Khan, T. J.; Meade, R.; Benedetto, S. E.; Belaygorod, L.; Saffaf, O.; Rusconi, B.; Hsu, F.-F.; Adak, S.; Arif, B.; Zaghloul, M.; Li, T.; Zhang, B.; Semenkovich, C. F.; Zayed, M. A.
10.1101/2025.03.11.642511 — molecular biology — Posted on 2025-03-14
2959 Mice carrying nonsense mutant p53 develop spontaneous tumors with frequent metastases
Strandgren, C.; Rondahl, V.; Oppelt, A.-S.; Öhlin, S.; Heldin, A.; Wiman, K. G.
10.1101/2025.03.12.642796 — cancer biology — Posted on 2025-03-14
2960 Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
Santambrogio, A.; Horne, R. I.; Metrick, M. A.; Brotzakis, Z. F.; Rinauro, D.; Vourkou, E.; Skoulakis, E. M.; Linse, S.; Caughey, B.; Vendruscolo, M.
10.1101/2025.03.09.642189 — biophysics — Posted on 2025-03-14
2961 Musical Insights into Protein Sequences and Functions via NMR Data
Moosavi-Movahedi, Z.; Lordifard, P.; Akhavijou, R.; Kavousi, K.; Ariaeenejad, S.; Beh-Afarin, R.; Mortazavian, A. M.; Shockravi, A.; Moosavi-Movahedi, A. A.; Zahra Moosavi-Movahedi {dagger}, Parinaz Lordifard {dagger}, Ramin Akhavijou, Kaveh Kavousi, Shohreh,
10.1101/2025.03.09.642256 — bioinformatics — Posted on 2025-03-14
2964 Climate-linked biogeography of mycorrhizal fungal spore traits
Pehim Limbu, S.; Sturmer, S. L.; Zahn, G.; Aguilar-Trigueros, C.; Rogers, N.; Chaudhary, V. B.
10.1101/2025.03.12.641256 — ecology — Posted on 2025-03-14
2965 GPR27 mediates adrenergic ligands-induced transinhibition of EGFR
Anghel, S. A.; Badea, R. A.; Trif, C.; Stratulat, T.; Trita, C.; Navligu, D. G.; Petrescu, S. M.; Babes, A.; Popescu, C. I.; Coman, C.; Hanson, J.; Tunaru, S.
10.1101/2025.03.12.642381 — cell biology — Posted on 2025-03-14
2970 MF-PENS: An Efficient and Versatile Nuclear Extraction Method for Plant Single-Cell Sequencing
Kang, J.; Du, L.; Chen, X.; Liu, Q.; Zhao, M.; Liu, F.; Song, Y.; Zhao, S.; Sun, X.; Tong, C.; Zhang, M.; Liang, Z.; Chen, R.; Yue, Z.
10.1101/2025.03.14.643295 — plant biology — Posted on 2025-03-14
2972 Chromosome-level genome assembly of the doctor fish (Garra rufa)
Kon, T.; Kon-Nanjo, K.; Handayani, K. S.; Zang, L.; Fahrurrozi, ; Simakov, O.; Gultom, V. D. N.; Shimada, Y.
10.1101/2025.03.11.642249 — genomics — Posted on 2025-03-14
2973 EpImAge: An Epigenetic-Immune Clock for Disease-Associated Biological Aging
Kalyakulina, A.; Yusipov, I.; Trukhanov, A.; Franceschi, C.; Moskalev, A.; Ivanchenko, M.
10.1101/2025.03.11.642648 — systems biology — Posted on 2025-03-14
2974 Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3
Mendoza-Castrejon, J.; Yang, W.; Denby, E.; Wang, H.; Casey, E. B.; Muthukumar, R.; Patel, R. M.; Yoon, J.; Li, Y.; White, J. M.; Chen, R.; Batista, L.; Magee, J. A.
10.1101/2025.03.11.642680 — cancer biology — Posted on 2025-03-14
2978 Defending Synthetic DNA Orders Against Splitting-Based Obfuscation
Tayouri, S.; Kogan, V.; Beal, J.; Levy, T.; Farbiash, D.; Flyangolts, K.; Mitchell, T.; Murphy, S. T.; Rotblat, B.; Veksler-Lublinsky, I.; Puzis, R.
10.1101/2025.03.12.642526 — bioinformatics — Posted on 2025-03-14
2979 raxtax: A k-mer-based non-Bayesian Taxonomic Classifier
Wahl, N. A.; Koutsovoulos, G. D.; Bettisworth, B.; Stamatakis, A.
10.1101/2025.03.11.642618 — bioinformatics — Posted on 2025-03-14
2980 CytoPheno: Automated descriptive cell type naming in flow and mass cytometry
Tursi, A. R.; Lages, C. S.; Quayle, K.; Koenig, Z. T.; Loni, R.; Eswar, S.; Cobena-Reyes, J.; Thornton, S.; Tilburgs, T.; Andorf, S.
10.1101/2025.03.11.639902 — bioinformatics — Posted on 2025-03-14
2982 Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency
Saha, K.; Saxena, S.; Kabra, M.; Abdeen, A. A.; Xie, R.; Sinha, D.; Zhu, M.; Hanstad, G. M.; Zepeda, M. A. F.; Pattnaik, B. R.; Gamm, D. M.; Gong, S.
10.1101/2025.03.12.642795 — genomics — Posted on 2025-03-14
2984 Conservation strategy insights for three protected Phengaris butterflies combining genetic and landscape analyses
Gauthier, J.; Sueur, A.; Pitteloud, C.; Clement, R.; Bilat, J.; Alvarez, N.; Gorius, N.; Danancher, D.
10.1101/2025.03.12.642762 — evolutionary biology — Posted on 2025-03-14
2986 Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair
Jiang, Y.; Przybilla, M.; Bakker, L.; Jacobs, F. C.; Mckeon, D.; van der Sluijs, R.; Wezenbeek, J.; van Strien, J.; Willems, J.; Verkennis, A. E. E.; Barnett, J.; Baez Ortega, A.; Abascal, F.; Villalta, P. W.; Knipscheer, P.; Martincorena, I.; Balbo, S.; Garaycoechea, J.
10.1101/2025.03.12.642750 — molecular biology — Posted on 2025-03-14
2988 Synaptic Gpr85 influences cerebellar granule cells electrical properties and light-induced behavior.
Darche-Gabinaud, R.; Kaafarani, A.; Chazalon, M.; Suain, V.; Hendrickx, E.; Conrard, L.; Lefort, A.; Libert, F.; Demirler, M. C.; Schiffmann, S.; Perez-Morga, D.; Wittamer, V.; Parmentier, M.; Pirson, I.
10.1101/2025.03.10.642364 — neuroscience — Posted on 2025-03-14
2990 Remote Cortical Network for Frontal Cognitive Symptoms derived from Tau Accumulation in Progressive Supranuclear Palsy
Hori, Y.; Endo, H.; Tagai, K.; Kataoka, Y.; Goto, R.; Kurose, S.; Momota, Y.; Kokubo, N.; Seki, C.; Moriguchi, S.; Shimada, H.; Shinotoh, H.; Tokuda, T.; Takahata, K.; Minamimoto, T.; Higuchi, M.; Hirabayashi, T.
10.1101/2025.02.05.636578 — neuroscience — Posted on 2025-03-14
2992 Social, cognitive and sensory dimensions of cortical network overconnectivity in young children with autism spectrum disorder
Rodriguez-Herreros, B.; Mheich, A.; Almeida Osorio, J. M.; Richetin, S.; Junod, V.; Arnold, L.; Aeschbach, V.; Adamou, L. N.; Mendes, L.; Gschwend, K.; Romascano, D.; Yu, P.; Maillard, A. M.; Jequier Gygax, M.; Murray, M. M.; HASSAN, M.; Chabane, N.
10.1101/2025.02.12.637813 — neuroscience — Posted on 2025-03-14
2993 Synthetic torpor in the rat recapitulates key features of torpor and is cardioprotective
Elley, M.; Taddei, L.; Khan, M. A.; Wilcox, U. R.; Hitrec, T.; Pickering, A. E.; Ambler, M.
10.1101/2025.03.12.642790 — neuroscience — Posted on 2025-03-14
2996 A standardized, open-source, portable model for noninvasive joint injury in mice
Newton, M. D.; Lammlin, L.; Gonzalez-Nolde, S.; Howser, S.; Smith, I.; Stasikelis, L.; Knights, A. J.; Maerz, T.
10.1101/2025.03.11.642661 — physiology — Posted on 2025-03-14
2997 Targeting SUV4-20H epigenetic enzymes as therapeutic strategy for enhancing topoisomerase II poisoning in prostate cancer
ALHOURANI, f.; TAUZIET, M.; PATOUILLARD, J.; MIOTTO, B.; BALDIN, V.; GENNETIER, A.; GEORGE, S.; Miahle, X.; RIBEYRE, C.; POURQUIER, P.; CAMMAS, F.; TORRO, A.; TOSI, D.; GONGORA, C.; DERGHAM, M.; ABOU MERHI, R.; JULIEN, E.
10.1101/2025.03.11.642623 — cancer biology — Posted on 2025-03-14
2998 WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
Tjeerdsma, R. B.; Ng, T.; Roorda, M.; Bianchi, D.; Yang, S.; Bonnet, C.; VanInsberghe, M.; Everts, M.; Bakker, F.; de Boer, R.; Moatti, N.; Hustedt, N.; Yin, J.; Hoeg, L.; Leibovitch, M.; Sicheri, F.; van Oudenaarden, A.; de Jong, S.; van den Berg, J.; Tanenbaum, M. E.; Brummelkamp, T. R.; Durocher, D.; van Vugt, M.
10.1101/2025.03.12.642754 — cancer biology — Posted on 2025-03-14
2999 IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma
Young, J.; Cho, N. W.; Lucas, C.-H. G.; Najem, H.; Mirchia, K.; Chen, W. C.; Seo, K.; Zakimi, N.; Daggubati, V.; Casey-Clyde, T.; Nguyen, M. P.; Chen, A.; Phillips, J. J.; Ozawa, T.; Aghi, M.; Taylor, J.; DeRisi, J. L.; Bhaduri, A.; Berger, M. S.; Heimberger, A. B.; Butowski, N.; Spitzer, M. H.; Raleigh, D. R.
10.1101/2025.03.12.642800 — cancer biology — Posted on 2025-03-14
3000 Fast and Furious: Metabolic Pathways Fuelling Devil Facial Tumour Disease
Gerard, A.-L.; Pirard, F.; Vanbeek, C.; Dujon, A. M.; Schultz, A.; Hamede, R.; Siddle, H. V.; Thomas, F.; McKenzie, M.; Ziemann, M.; Ujvari, B.
10.1101/2025.03.12.642198 — cancer biology — Posted on 2025-03-14
3001 Molecular insights on the mechanism of α1-antitrypsin condensate formation and maturation
Sanchez-Burgos, I.; Tejedor, A. R.; Collepardo-Guevara, R.; de la Serna, J. B.; Espinosa, J. R.
10.1101/2025.03.11.642656 — biophysics — Posted on 2025-03-14
3006 KcatNet: advancing genome-wide enzyme turnover number prediction through structural enzymatic characterization
Pan, T.; Cui, X.; Koh, H. Y.; Bi, Y.; Wang, X.; Zhang, Y.; Hu, S.; Webb, G. I.; Kurgan, L.; Zhang, G.; Song, J.
10.1101/2025.03.09.642294 — bioinformatics — Posted on 2025-03-14
3007 RNA2seg: a generalist model for cell segmentation in image-based spatial transcriptomics
Defard, T.; Blondel, A.; Bellow, S.; Coleon, A.; Dias de Melo, G.; Walter, T.; Mueller, F.
10.1101/2025.03.03.641259 — bioinformatics — Posted on 2025-03-14
3011 Third-party imitation is not restricted to humans
Haldar, E.; Sanchez, A. H.; Tennie, C.; Ortiz, S. T.; Vos, J.; Valbert, M.; von Bayern, A. M. P.
10.1101/2025.03.14.643244 — animal behavior and cognition — Posted on 2025-03-14
3012 DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis
Gamarra, N.; Chittenden, C.; Sundararajan, K.; Schwartz, J. P.; Lundqvist, S.; Robles, D.; Dixon-Luinenburg, O.; Marcus, J.; Maslan, A.; Franklin, J. M.; Streets, A.; Straight, A. F.; Altemose, N.
10.1101/2025.03.11.642717 — genomics — Posted on 2025-03-14
3014 Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans
Chang, H.-Y.; McMurry, S. E.; Ma, S.; Mansour, C. A.; Schwab, S. M. T.; Danko, C. G.; Lee, S. S.
10.1101/2025.03.11.642714 — genomics — Posted on 2025-03-14
3015 Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome
Semenova, S. A.; Sams, A. M.; Nammi, D.; Menold, M.; Margolin, G.; Sinclair, J. L.; Robertson, K. A.; Larkin, K.; Kelly, S.; Golden, A.; Feldman, B.; Burgess, H. A.
10.1101/2025.03.11.642683 — genetics — Posted on 2025-03-14
3018 Mobile species' responses to surrounding land use generate trade-offs among nature's contributions to people
O'Brien, S. A.; Tylianakis, J. M.; Anderson, D. P.; Boesing, A. L.; Lai, H. R.; Le Provost, G.; Manning, P.; Neyret, M.; Blüthgen, N.; Jung, K.; Magdon, P.; Mueller, S.; Scherer-Lorenzen, M.; Schenk, N.; Lavorel, S.
10.1101/2025.03.11.638535 — ecology — Posted on 2025-03-14
3020 A spatially explicit model of pollinator-plant-pathogen interactions
Rands, S. A.; Botias, C.; Nicholls, E. A.; Hempel de Ibarra, N.
10.1101/2025.03.11.642689 — ecology — Posted on 2025-03-14
3021 Fine-scale spatial patterns in hot springs mat bacterial communities
Arroyo, J. I.; Pedros-Alio, C.; Polz, M. F.; Mackenzie, R.; Marquet, P.; Diez, B.
10.1101/2025.03.11.642739 — ecology — Posted on 2025-03-14
3022 Human growth plates house resting zone sub-populations with features of quiescent stem cells
Avijgan, M.; Perez, A. R. L.; Galicia, L. A.; Sudupe, L.; Marchan-Alvarez, J. G.; Nazaraliyev, A.; Andrusivova, Z.; Larsson, L.; Zhao, Y.; Zaman, F.; Qian, H.; Blomgren, K.; Prosper, F.; Tegner, J. N.; Lundeberg, J.; Savendahl, L.; Mirzazadeh, R.; Gomez-Cabrero, D.; Newton, P. T.
10.1101/2025.03.12.642613 — molecular biology — Posted on 2025-03-14
3023 Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice
Yilmazer, A.; Eugster, A.; Zevla, D. M.; Helbich, S. S.; Boernert, M.; Torun, B.; Marsela, E.; Kirgin, E.; Dahl, A.; Petzold, A.; Kershaw, O.; Alexaki, V. I.; Chatzigeorgiou, A.; Delacher, M.; Schlenner, S.; Kretschmer, K.
10.1101/2025.03.12.642664 — immunology — Posted on 2025-03-14
3024 Long-term neuron tracking reveals balance of stability and plasticity in functional properties
Lu, H.-Y.; Stealey, H. M.; Zhao, Y.; Barnett, C. R.; Contreras-Hernandez, E.; Santacruz, S. R.
10.1101/2025.03.14.643204 — neuroscience — Posted on 2025-03-14
3025 Validating FOXO4 as a therapeutic target for protecting against ischemia-reperfusion-caused neuronal injury
Asadi, Y.; Gorjipour, F.; Chakroborty, A.; Moundounga, R.; Dwamena, A.; Gilstrap, E.; Wang, H.
10.1101/2025.03.13.643180 — neuroscience — Posted on 2025-03-14
3026 An In Vivo Model of Alpha-Synuclein Spread from Gut to Brain
Barnhill, L.; Khuansuwan, S.; El Nachef, W.; Ha, S. M.; Arellano, M.; Hasan, K. M. M.; Kim, A.; Bronstein, J. M.
10.1101/2025.03.13.643189 — neuroscience — Posted on 2025-03-14
3027 The Pesticide Chlorpyrifos Increases the Risk of Parkinson's Disease
Hasan, K. M. M.; Barnhill, L.; Paul, K. C.; Peng, C.; Zeiger, W.; Ritz, B. R.; Arellano, M.; Ajnassian, M.; Zhang, S.; Theint, A. T.; Elezi, G.; Weinberger, H.; Whitelegge, J. P.; Bai, Q.; Li, S.; Burton, E.; Bronstein, J. M.
10.1101/2025.03.13.643184 — neuroscience — Posted on 2025-03-14
3031 Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients
Ishii, T.; Wang, T.; Shibata, K.; Nishitani, S.; Yamanashi, T.; Wahba, N. E.; Seki, T.; Thompson, K. J.; Yamanishi, K.; Nishiguchi, T.; Shimura, A.; Aoyama, B.; Gorantla, N.; Phuong, N. J.; Nguyen, H. D.; Santiago, T. A.; Nishizawa, Y.; Nagao, T.; Howard, M. A.; Kawasaki, H.; Hino, K.; Ikeda, A.; Snyder, M. P.; Shinozaki, G.
10.1101/2025.03.13.643155 — neuroscience — Posted on 2025-03-14
3033 Unraveling Regulatory Feedback Mechanisms in Adult Neurogenesis Through Mathematical Modelling
Danciu, D.-P.; Klawe, F. Z.; Femmer, L.; Kostina, E.; Martin-Villalba, A.; Marciniak-Czochra, A.
10.1101/2025.03.12.642763 — systems biology — Posted on 2025-03-14
3034 The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming
Grimmett, Z. W.; Zhang, R.; Zhou, H.-L.; Chen, Q.; Miller, D.; Qian, Z.; Lin, J.; Kalra, R.; Gross, S.; Koch, W. J.; Premont, R. T.; Stamler, J. S.
10.1101/2025.03.12.642752 — physiology — Posted on 2025-03-14
3035 Harnessing ALDH1A2 vulnerability in T-cell acute lymphoblastic leukemia
Andrieu, G. P.; Courtois, L.; Bonnet, M.; Gillet, C.; Queri, M.; Feroul, M.; Lhermitte, L.; Villarese, P.; Cabannes-Hamy, A.; Rousselot, P.; Perez, M.; Ceylan, I.; Spicuglia, S.; Asnafi, V.
10.1101/2025.03.11.642712 — cancer biology — Posted on 2025-03-14
3036 Characterization of MEK1/2 Degraders Uncovers a Kinase-Independent Role for MEK1/2 in the Stabilization and Maturation of CRAF
Wasserman, J. S.; Kurimchak, A. M.; Herrera-Montavez, C.; Doyle, G. A.; Fox, B. D.; Kodikara, I. K. M.; Hu, X.; Hu, J.; Jin, J.; Duncan, J. S.
10.1101/2025.03.11.642495 — cancer biology — Posted on 2025-03-14
3039 Volumetric 3D Printing and Melt-Electrowriting to Fabricate Implantable Reinforced Cardiac Tissue Patches
Jones, L. S.; Biefer, H. R. C.; Mekkattu, M.; Thijssen, Q.; Amicone, A.; Bock, A.; Weisskopf, M.; Zorndt, D.; Meier, D.; Zheng, L.; Generali, M.; Katzschmann, R.; Dzemali, O.
10.1101/2025.03.11.642643 — bioengineering — Posted on 2025-03-14
3041 Molecular Insights into Cell Wall Architecture and Xylan-Bound Cellulose Fibrils in the Wheat Straw
Hu, Y.; Yu, S.; Ling, Z.; Xiao, P.; Zhu, Y.; Miao, G.; He, Y.; Li, H.; Chen, S.; You, T.; Wang, T.; Xu, F.
10.1101/2025.03.11.642666 — biochemistry — Posted on 2025-03-14
3042 Stress-dependent activation of PQM-1 orchestrates a second-wave proteostasis response for organismal survival
Jones, L.; Uvarova, V.; O'Brien, D.; McIntyre, H.; Cohen, N. R.; Dowen, R. H.; van Oosten-Hawle, P.
10.1101/2025.03.11.642454 — genetics — Posted on 2025-03-14
3043 Stability of influenza A H5N1 virus in raw milk cheese
Nooruzzaman, M.; de Oliveira, P. S. B.; Martin, N. H.; Alcaine, S. D.; Diel, D.
10.1101/2025.03.13.643009 — microbiology — Posted on 2025-03-14
3044 Co-release of opposing signaling molecules from cortical neurons controls the escalation and release of aggression
Gatlin, R. E.; Gagon, J.; Park, S.; Kwak, D.; Walker, H.; Kroheim, L.; Everett, T.; Covington, A.; Fluck, M. M.; Zickmund, T.; Frost, N. A.; Zelikowsky, M.
10.1101/2025.03.13.643119 — neuroscience — Posted on 2025-03-14
3047 Sharks and rays have the oldest vertebrate sex chromosome with unique sex determination mechanisms
Niwa, T.; Uno, Y.; Ohishi, Y.; Kadota, M.; Aburatani, N.; Kiyatake, I.; Katooka, D.; Yorozu, M.; Tsuzuki, N.; Toyoda, A.; Takagi, W.; Nakamura, M.; Kuraku, S.
10.1101/2025.03.13.642935 — evolutionary biology — Posted on 2025-03-14
3049 Chronic lysosome damage boosts interferon responses to Palbociclib through a mitochondrial signalling axis
Bozic, M.; Lim, T. E.; Kemp, A. J.; Winnington-Ingram, K.; Murphy, L.; Dhir, A.; Wheeler, A.; Jimenez-Moreno, N.; Wilkinson, S.
10.1101/2025.03.13.642980 — cell biology — Posted on 2025-03-14
3050 Impaired stem cell migration and divisions in Duchenne Muscular Dystrophy revealed by live imaging
Sarde, L.; Letort, G.; Varet, H.; Laville, V.; Fernandes, J.; Tajbakhsh, S.; Evano, B.
10.1101/2025.03.13.643016 — cell biology — Posted on 2025-03-14
3051 RPGR regulates motile cilia by interfering with actin dynamics
Wu, Y.; Tavares, E.; Liang, B.; Wee, W.; Mennella, V.; Feng, H.; Cao, J.; Zheng, J.; He, M.; Stephenson, K.; Hanan, L.; Li, J. M.; Dell, S. D.; Heon, E.; LIU, Z.
10.1101/2025.03.13.643176 — cell biology — Posted on 2025-03-14
3060 HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions
Rokicki, K.; Schauder, D.; Olbris, D. J.; Goina, C.; Clements, J.; Edson, P.; Kawase, T.; Svirskas, R.; Arshadi, C.; Feng, D.; Chandrashekar, J.; Ferreira, T. A.; MouseLight Project Team,
10.1101/2025.03.13.642887 — neuroscience — Posted on 2025-03-14
3068 Micron-resolution fiber mapping in histology independent of sample preparation
Georgiadis, M.; auf der Heiden, F.; Abbasi, H.; Ettema, L.; Nirschl, J.; Moein Taghavi, H.; Wakatsuki, M.; Liu, A.; Ho, W. H. D.; Carlson, M.; Doukas, M.; Koppes, S. A.; Keereweer, S.; Sobel, R. A.; Setsompop, K.; Liao, C.; Amunts, K.; Axer, M.; Zeineh, M. M.; Menzel, M.
10.1101/2024.03.26.586745 — pathology — Posted on 2025-03-14
3070 Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction
Bresciani, V.; Rinaldi, F.; Franco, P.; Girotto, S.; Cavalli, A.; Langer, J. D.; Masetti, M.; Bernetti, M.
10.1101/2025.03.07.642044 — biophysics — Posted on 2025-03-14
3071 An Integrative Approach to Rational Engineering of Dengue Virus-Like Particles
Palur, V. R.; Chen, F.-C.; Wu, S.-R.; Chen, G.-W.; Bond, P. J.; Chao, D.-Y.; Marzinek, J. K.
10.1101/2025.03.11.642607 — biophysics — Posted on 2025-03-14
3078 C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis
Jiang, R.; Chouchane, M.; Chen, K. S.; Moey, C.; Bunt, J.; Li, J.; Allkuraya, F.; Alobeid, E.; Richards, L.; Ullian, E.; Sherr, E.
10.1101/2025.01.08.632037 — neuroscience — Posted on 2025-03-14
3080 Automated hierarchical block decomposition of biochemical networks
Gasparyan, M.; Tamby, S.; HarshaRani, G. V.; Bhalla, U. S.; Radulescu, O.
10.1101/2025.03.07.642055 — systems biology — Posted on 2025-03-14
3089 KcatNet: advancing genome-wide enzyme turnover number prediction through structural enzymatic characterization
Pan, T.; Cui, X.; Koh, H. Y.; Bi, Y.; Wang, X.; Zhang, Y.; Hu, S.; Webb, G. I.; Gasser, R.; Kurgan, L.; Zhang, G.; Song, J.
10.1101/2025.03.09.642294 — bioinformatics — Posted on 2025-03-13
3090 Using the ancestral recombination graph to study the history of rare variants in founder populations
Mejia-Garcia, A.; Diaz-Papkovich, A.; Sillon, G.; D'Agostino, D.; Chong, A.-L.; Chong, G.; Lo, K. S.; Baret, L.; Hamel, N.; Chapdelaine, V.; Foulkes, W. D.; Taliun, D.; Shapiro, A. J.; Lettre, G.; Gravel, S.
10.1101/2025.03.13.643149 — genetics — Posted on 2025-03-13
3091 Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
Conway, O. J.; Christopher, J. A.; Breckels, L. M.; Li, H.; Menon, D.; Liang, L.; Patel, S.; Gershlick, D. C.; Savage, D. B.; Weekes, M. P.; Lilley, K. S.; Fazakerley, D. J.
10.1101/2025.03.13.642412 — cell biology — Posted on 2025-03-13
3093 Lipid packing frustration in the outer leaflet of the plasma membrane prevents scission of caveolae
Larsson, E.; Kabedev, A.; Pace, H.; Lindwall, J.; Bano, F.; Parton, R. G.; Bergstrom, C. A. S.; Parmryd, I.; Bally, M.; Lundmark, R.
10.1101/2025.03.13.643064 — cell biology — Posted on 2025-03-13
3095 High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease
Cardona, C. L.; Wei, L.; Kim, J.; Angeles, E.; Singh, G.; Chen, S.; Ifediora, N.; Canoll, P.; Teich, A. F.; Hargus, G.; Chavez, A.; Sproul, A. A.
10.1101/2025.03.09.642133 — neuroscience — Posted on 2025-03-13
3096 The Endo-GeneScreen Platform Identifies Drug-Like Probes that Regulate Endogenous Protein Levels within Physiological Contexts
Samowitz, P.; Radnai, L.; Vaissiere, T. D.; Michaelson, S. D.; Rojas, C.; Mitchell, R.; Kilinc, M.; Edwards, A.; Shumate, J.; Hawkins, R.; Fernandez-Vega, V.; Spicer, T. P.; Scampavia, L.; Kamenecka, T.; Miller, C. A.; Rumbaugh, G.
10.1101/2025.03.13.643156 — neuroscience — Posted on 2025-03-13
3100 Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
Cording, K. R.; Tu, E. M.; Wang, H.; Agopyan-Miu, A. H. C. W.; Bateup, H. S.
10.1101/2024.05.09.593387 — neuroscience — Posted on 2025-03-13
3103 Gene combinations driving transformation of tubal epithelial organoids and differential sensitivity to high-grade serous ovarian carcinoma drugs
Phuong, D. J.; Ralston, C. Q.; Ezzat, T. M.; Ashe, C. S.; Armstrong, A. P.; Flesken-Nikitin, A.; Yamulla, R. J.; Nikitin, A. Y.; Schimenti, J. C.
10.1101/2025.03.10.642422 — cancer biology — Posted on 2025-03-13
3105 GlycoGenius: the ultimate high-throughput glycan composition identification tool
Loponte, H. F.; Zheng, J.; Ding, Y.; Oliveira, I. A.; Basse, K.; Todeschini, A. R.; Horvatovich, P.; Lageveen-Kammeijer, G. S. M.
10.1101/2025.03.10.642485 — bioinformatics — Posted on 2025-03-13
3107 Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes
Wang, S.-T.; Anahtar, M.; Kim, D. M.; Samad, T. S.; Zhang, C. M.; Patel, S.; Ko, H.; Ngambenjawong, C.; Wang, C. S.; Kirkpatrick, J. D.; Kumar, V.; Fleming, H. E.; Bhatia, S. N.
10.1101/2024.12.30.630769 — bioengineering — Posted on 2025-03-13
3110 How sleeping minds decide: state-specific reconfigurations of lexical decision-making
Xia, T.; Hu, C.-P.; Turker, B.; Musat, E. M.; Naccache, L.; Arnulf, I.; Oudiette, D.; Hu, X.
10.1101/2025.03.10.642374 — neuroscience — Posted on 2025-03-13
3112 Interferon signaling underlies radiotherapy responses in malignant peripheral nerve sheath tumors (MPNSTs)
Zhu, I.; Chien, J.; Mirchia, K.; Pan, S.; Miller, K.; Pak, J.; Wustrack, R.; Monga, V.; Braunstein, S. E.; Jacques, L.; Pekmezci, M.; Liu, S. J.; Vasudevan, H. N.
10.1101/2025.03.09.642167 — cancer biology — Posted on 2025-03-13
3114 Organoid-based modeling of platinum resistance identifies KRT17 as both a response mediator and biomarker for targeted therapy in ovarian cancer
Reichenbach, J.; Schmid, J.; Hierlmayer, S.; Zhang, T.; Piga, I.; Geweniger, S.; Fischer, J.; Davesar, A.; Vasovic, N.; Chelariu-Raicu, A.; Kraus, F.; Burges, A.; Czogalla, B.; Mayr, D.; Straub, T.; Klein, C.; Olsen, J. V.; Mahner, S.; Trillsch, F.; Kessler, M.
10.1101/2025.03.10.642373 — cancer biology — Posted on 2025-03-13
3118 Modulation of TTR Gene Expression in the Eye using Modified Duplex RNAs
Corey, D. R.; Hu, J.; Mootha, V.; Gong, X.; Egli, M.; Manoharan, M.; Kundu, J.; Corey, D.
10.1101/2025.03.11.642595 — biochemistry — Posted on 2025-03-13
3119 A Latent Activated Olfactory Stem Cell State Revealed by Single Cell Transcriptomic and Epigenomic Profiling
Van den Berge, K.; Bakalar, D.; Chou, H.-J.; Kunda, D.; Risso, D.; Street, K.; Purdom, E.; Dudoit, S.; Ngai, J.; Heavner, W. E.
10.1101/2023.10.26.564041 — genomics — Posted on 2025-03-13
3122 ATRX safeguards cellular identity during C. elegans development
Olver, J.; Shtumpf, M.; Hussain, K.; Methot, S.; Sarkies, P.; Ferreira, H. C.
10.1101/2025.03.11.641662 — molecular biology — Posted on 2025-03-13
3126 Dickkopf1 is a Novel Endogenous Ligand for priming NLRP3 Inflammasome in Macrophages via TLR4
Aung, T.; Song, S.; Kasongo, J.; Harada, H.; Zhang, S.; Henegariu, O.; Chae, W.-J.
10.1101/2025.03.11.642660 — immunology — Posted on 2025-03-13
3128 Pathological tau activates inflammatory nuclear factor-kappa B (NF-κB) and pT181-Qβ vaccine attenuates NF-κB in PS19 tauopathy mice
Tangavelou, K.; Jiang, S.; Dadras, S.; Hulse, J.; Sanchez, K.; Bondu, V.; Villasenor, Z.; Mandell, M. A.; Peabody, J.; Chackerian, B. A.; Bhaskar, K.
10.1101/2025.03.10.642500 — neuroscience — Posted on 2025-03-13
3130 Amino acids activate parallel chemosensory pathways in Drosophila
Guillemin, J.; Davis, G.; Audette, K.; Avonda, T.; Freed, E.; Woods, B.; Wagner, E.; Schwartz, L. T.; Orsmond, I.; Hampp, B.; Burdick, M.; Grause, P.; Taylor, S.; Asaro, B.; Sperber, A.; Zoller, K. A.; Stanley, M.
10.1101/2025.03.10.642418 — neuroscience — Posted on 2025-03-13
3132 Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial Activation
Brito, P. L.; Gushiken, L. F. S.; Gotardo, E. M. F.; Figueiredo, V.; Leonardo, F. C.; Costa, F. F.; Conran, N.
10.1101/2025.03.10.642471 — physiology — Posted on 2025-03-13
3134 Non-Invasive Quantification of Viability in Spheroids Using Deep Learning
Dubinsky, D.; Harel, S.; Bein, A.; Nyska, A.; Yaari, S.; Koc, B.; Anas, F.; Bentwich, I.; Wolf, L.
10.1101/2025.03.09.642246 — pharmacology and toxicology — Posted on 2025-03-13
3136 SLAP controls mTORC2 integrity via UBE3C-mediated mLST8 ubiquitination to mediate its tumour suppressive function in colorectal cancer
Mevizou, R.; Naim, D.; Cauchois, F.; Naudin, C.; Greaves, G.; Espie, K.; Felipe, B.; Simon, V.; Boublik, Y.; Nguyen, J.; Urbach, S.; Roche, S.; Sirvent, A.
10.1101/2025.03.10.642361 — cancer biology — Posted on 2025-03-13
3138 The Origin, Diagnosis, and Prognosis of Oligomannose-Type Diffuse Large B Cell Lymphoma
Tatterton, D. J.; Newby, M. L.; Allen, J. D.; Sale, B. J.; Chiodin, G.; Duriez, P. J.; Butler, J.; McCann, K. J.; Scott, D. W.; Morin, R. D.; Dreval, K.; Davies, A. S.; Bryant, D. J.; Crispin, M.; Forconi, F.
10.1101/2025.03.11.642396 — cancer biology — Posted on 2025-03-13
3139 Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system
Egetemaier, S. M.; Chauvistre, H.; Varaljai, R.; Hua, Y.; Lueong, S. S.; Makhzami, S.; Srinivas, N.; Forster, J.; Ullrich, V.; Stupia, S.; Schroeder, V.; Scharfenberg, S.; Hoewner, A.; Shannan, B.; Siveke, J.; Baietti, M. F.; Leucci, E.; Marine, J.-C.; Paschen, A.; Scheffler, B.; Engel, D. R.; Becker, L. M.; Nensa, F.; Koester, J.; Gruenwald, B. T.; Poepsel, S.; Ninck, S.; Kaschani, F.; Schadendorf, D.; Becker, J. C.; Tasdogan, A.; Rambow, F.; Roesch, A.
10.1101/2025.03.10.641595 — cancer biology — Posted on 2025-03-13
3144 Unifying DNA methylation-based in silico cell-type deconvolution with methyldeconv
Dietrich, A.; Willruth, L.-L.; Puerckhauer, K.; Oltmanns, C.; Witte, M.; Klein, S.; Kraft, A.; Cornberg, M.; List, M.
10.1101/2025.03.10.642382 — bioinformatics — Posted on 2025-03-13
3150 Evidence Aggregator: AI reasoning applied to rare disease diagnostics
Twede, H.; Conard, A. M.; Pais, L.; Bryen, S.; O'Heir, E.; Smith, G.; Paulsen, R.; Austin-Tse, C. A.; Bloemendal, A.; Simons, C.; Saponas, S.; Wander, J. D.; MacArthur, D. G.; Rehm, H. L.
10.1101/2025.03.10.642480 — genomics — Posted on 2025-03-13
3155 Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms
Hansen, S. B.; Bartual, S. G.; Yuan, H.; Raimi, O.; Gorelik, A.; Ferenbach, A. T.; Lytje, K.; Pedersen, J. S.; Drace, T.; Boesen, T.; van Aalten, D. M. F.
10.1101/2025.03.10.642372 — molecular biology — Posted on 2025-03-13
3156 NF-κB signaling directs a program of transient amplifications at innate immune response genes
Ludwig, M. P.; Wilson, J. R.; Galbraith, M. D.; Bhandari, N.; Dunn, L. N.; Black, J. C.; Sullivan, K. D.
10.1101/2025.03.11.641929 — molecular biology — Posted on 2025-03-13
3158 Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Agius, S. C.; Boudes, M.; Healy, E.; Chang, Y.-C.; Murray, M.; Manent, J.; Rientjes, J.; Lai, Z.; Nixon, S.; Levina, V.; McGlinn, E.; Davidovich, C.
10.1101/2025.03.13.642955 — molecular biology — Posted on 2025-03-13
3160 Soluble TREM2 is a biomarker but not a mediator of fibrosing steatohepatitis
Dempsey, J. L.; Savard, C.; Kothari, V.; Tang, J.; Lee, S. P.; Bornfeldt, K. E.; Carr, R. M.; Ioannou, G. N.
10.1101/2025.03.11.642665 — molecular biology — Posted on 2025-03-13
3162 The Staphylococcus aureus prophage-encoded SSBP attenuates virulence and enhances IL-6-mediated macrophage clearance
Ahmad-Mansour, N.; Abi Najem, C. N.; Martin, M.; Plumet, L.; Huc-Brandt, S.; Morsli, M.; Francois, P.; Sotto, A.; Dunyach-Remy, C.; Lavigne, J.-P.; MOLLE, V.
10.1101/2025.03.13.643069 — microbiology — Posted on 2025-03-13
3163 Master control of protein secretion by Mycobacterium tuberculosis
Ravindran Nair, R.; Meikle, V.; Dubey, S.; Pavlenok, M.; Niederweis, M.
10.1101/2025.03.13.643117 — microbiology — Posted on 2025-03-13
3165 The experimentally evolved fluconazole-resistant Clade II isolates of Candidozyma auris exhibit a distinct lipid compositional landscape, highlighting intra-clade sphingolipid heterogeneity
kumar, P.; Ali, B.; Kumar, M.; Carolus, H.; Romero, C. L.; Vergauwen, R.; Chauhan, A.; Narayanan, A.; Banerjee, A.; Gaur, N. A.; Singh, A.; Van Dijck, P.; Chakrabarti, A.; Rudramurthy, S. P. M.; Sanyal, K.; Prasad, R.
10.1101/2025.03.13.642928 — microbiology — Posted on 2025-03-13
3167 Diclofenac stress responses and biotransformation pathways in the marine diatom Phaeodactylum tricornutum
Alezra, L.; Le Floch, E.; Felix, C.; Rosain, D.; Gomez, E.; Courant, F.; Fouilland, E.; Cheloni, G.
10.1101/2025.03.13.643036 — microbiology — Posted on 2025-03-13
3168 Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
Giustarini, G.; Skrabanja, T. L.; van den Berg, A. E.; van Staveren, S.; Vos, T.; Zhou, Z. H.; Klaessens, T.; Mulder, E.; Klazen, J. A.; Smit, J.; Pieters, R.; Koenderman, L.; Vrisekoop, N.
10.1101/2025.03.10.642492 — immunology — Posted on 2025-03-13
3169 Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses
Rood, J. E.; Yoon, S. K.; Heard, M. K.; Carro, S. D.; Hedgepeth, E. J.; O'Mara, M. E.; Hogan, M. J.; Le, N.; Muramatsu, H.; Lam, K.; Schreiner, P.; Kasden, C.; Stedman, H.; Langlois, R. A.; Heyes, J.; Pardi, N.; Eisenlohr, L. C.
10.1101/2025.03.11.642674 — immunology — Posted on 2025-03-13
3170 Subliminal risk influences subjective value in the ventromedial prefrontal cortex
Fernandes, P.; Lee, S.; Kable, J. W.; Seidel, P.; Almeida, J.; Eriksson, J.; de Sousa, B.; Bergstrom, F.
10.1101/2025.03.11.642695 — neuroscience — Posted on 2025-03-13
3171 How sleeping minds decide: state-specific reconfigurations of lexical decision-making
Xia, T.; Hu, C.-P.; Turker, B.; Musat, E. M.; Naccache, L.; Arnulf, I.; Oudiette, D.; Hu, X.
10.1101/2025.03.10.642374 — neuroscience — Posted on 2025-03-13
3172 SORDINO for Silent, Sensitive, Specific, and Artifact-Resisting fMRI in awake behaving mice
Mackinnon, M. J.; Song, S.; Chao, T.-H. H.; Hsu, L.-M.; Albert, S. T.; Ma, Y.; Shnitko, T.; Wang, T.-W. W.; Nonneman, R. J.; Freeman, C. D.; Ozarkar, S. S.; Emir, U. E.; Shen, M. D.; Philpot, B. D.; Hantman, A. W.; Lee, S.-H.; Chang, W.-T.; Shih, Y.-Y. I.
10.1101/2025.03.10.642406 — neuroscience — Posted on 2025-03-13
3180 CREB-family transcription factors and vasopressin-mediated regulation of Aqp2 gene transcription
Murillo-de-Ozores, A. R.; Chen, L.; Ou, S.-M.; Park, E.; Khan, S.; Raghuram, V.; Yang, C.-R.; Chou, C.-L.; Knepper, M. A.
10.1101/2025.03.10.642395 — physiology — Posted on 2025-03-13
3181 Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin
Elliehausen, C. J.; Olszewski, S. S.; Shult, C. G.; Ailiani, A. R.; Trautman, M. E.; Babygirija, R.; Lamming, D. W.; Hornberger, T. A.; Minton, D. M.; Konopka, A. R.
10.1101/2025.03.10.642477 — physiology — Posted on 2025-03-13
3182 Envirotyping Facilitates Understanding of Genotype x Environment Interactions and Highlights the Potential of Stay-green Traits in Wheat
Amin, A.; Christopher, J.; Forknall, C.; Cooper, M.; Macdonald, B.; Collins, B.; Voss-Fels, K.; Hickey, L.; Chenu, K.
10.1101/2025.03.11.642575 — physiology — Posted on 2025-03-13
3184 Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Jonker, P. B.; Sadullozoda, M.; Cognet, G.; Saab, J. J. A.; Sokol, K. H.; Wu, V. X.; Kumari, D.; Sheehan, C.; Ozgurses, M. E.; Agovino, D.; Croley, G.; Patel, S. A.; Bock-Hughes, A.; Macleod, K. F.; Shah, H.; Coloff, J. L.; Lien, E. C.; Muir, A.
10.1101/2025.03.10.642426 — cancer biology — Posted on 2025-03-13
3185 KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
Izzo, L. T.; Reyes, T.; Meesala, S.; Ireland, A. S.; Yang, S.; Sunil, H. S.; Cheng, X. C.; Tserentsoodol, N.; Hawgood, S. B.; Patz, E. F.; Witt, B. L.; Tyson, D. R.; O'Donnell, K. A.; Oliver, T. G.
10.1101/2025.03.10.641898 — cancer biology — Posted on 2025-03-13
3186 Preventing neuropathy and improving anti-cancer chemotherapy with a carbazole-based compound
Bosc, L.; Pero, M. E.; Balayssac, D.; Jacquemot, N.; Allard, J.; Suzanne, P.; Vollaire, J.; Cottet-Rousselle, C.; Michallet, S.; Villaret, J.; Torch, S.; Marais, S.; Elena-Herrmann, B.; Schlattner, U.; Mercier, A.; Josserand, V.; Thibert, C.; Dallemagne, P.; Bartolini, F.; Lafanechere, L.
10.1101/2025.03.10.642317 — cancer biology — Posted on 2025-03-13
3187 Leukemic Cells Manipulate MSCs Bioelectrical Signals to Reshape the Bone Marrow Niche
Borella, G.; Benetton, M.; Da Ros, A.; Longo, G.; Borile, G.; Cani, A.; Lopez-Pigozzi, D.; Bortolozzi, M.; Bresolin, S.; Tregnago, C.; Locatelli, F.; Pigazzi, M.
10.1101/2025.03.10.642319 — cancer biology — Posted on 2025-03-13
3188 Pathogenic Viruses, Genome Integrations, and Viral::Human Chimeric Transcripts Detected by VirusIntegrationFinder Across >30k Human Tumor and Normal Samples
Haas, B. J.; Van Arsdale, A.; Dobin, A.; Brown, M.; Gould, J.; Georgescu, C.; Agosta, E.; Baulande, S.; Jamail, I.; Kamal, M.; Bieche, I.; Lenz, J.; Montagna, C.; Al'Khafaji, A.
10.1101/2025.03.10.642430 — cancer biology — Posted on 2025-03-13
3189 A tumor necrosis factor-α responsive cryptic promoter drives overexpression of the human endogenous retrovirus ERVK-7
LEE, S.; Ho, Y. Y.; Hao, S.; Ouyang, Y.; Liew, U. L.; Goyal, A.; Li, S.; Barbour, J. A.; He, M.; Huang, Y.; Wong, J. W. H.
10.1101/2025.03.09.642286 — cancer biology — Posted on 2025-03-13
3192 Inhibition of ice recrystallization with designed twistless helical repeat proteins
de Haas, R. J.; Pyles, H.; Huddy, T. F.; van Ossenbruggen, J.; Zheng, C.; van den Broek, D.; Carr, A.; Bera, A.; Kang, A.; Brackenbrough, E.; Joyce, E.; Sankaran, B.; Baker, D.; Voets, I.; de Vries, R.
10.1101/2025.03.09.642278 — biophysics — Posted on 2025-03-13
3194 RamEx: An R package for high-throughput microbial ramanome analyses with accurate quality assessment
Zhang, Y.; Jing, G.; Chen, R.; Gong, Y.; Li, Y.; Wang, Y.; Wang, X.; Zhang, J.; Mao, Y.; He, Y.; Zheng, X.; Wang, M.; Yuan, H.; Xu, J.; Sun, L.
10.1101/2025.03.10.642505 — bioinformatics — Posted on 2025-03-13
3195 Detecting aberrant splicing events in short-read RNA-seq with SAMI, an UMI-aware Nextflow pipeline
Mareschal, S.; Wucher, V.; Huet, S.; Leonce, C.; Chabane, K.; Hayette, S.; Bringuier, P.-P.; Pinson, S.; Barritault, M.; Bardel, C.
10.1101/2025.03.10.642333 — bioinformatics — Posted on 2025-03-13
3197 ClairS-TO: A deep-learning method for long-read tumor-only somatic small variant calling
Chen, L.; Zheng, Z.; Su, J.; Yu, X.; Wong, A. O. K.; Zhang, J.; Lee, Y.-L.; Luo, R.
10.1101/2025.03.10.642523 — bioinformatics — Posted on 2025-03-13
3201 A Hyperbolic Discrete Diffusion 3D RNA Inverse Folding Model for functional RNA design
Hou, D.; Zhang, S.; Ma, M.; Lin, H.; Wan, Z.; Zhao, H.; Zhou, R.; He, X.; Wei, X.; Ju, D.; Zeng, X.
10.1101/2025.03.11.642534 — bioinformatics — Posted on 2025-03-13
3202 Benchmarking AlphaFold3-like Methods for Protein-Peptide Complex Prediction
Zhou, F.; Guo, S.; Peng, X.; Zhang, S.; Men, C.; Duan, X.; Zhu, G.; Zheng, L.; Liu, H.; Wang, S.
10.1101/2025.03.09.642277 — bioinformatics — Posted on 2025-03-13
3204 Precise, Specific, and Sensitive De Novo Antibody Design Across Multiple Cases
Bang, Y.; Cho, K.; Gu, J.; Kang, S.; Kwon, S.; Lee, D.; Lee, M. S.; Lee, S.; Lee, S. J.; Lim, J.; Maeng, J. Y.; Noh, J.; Oh, H.; Oh, S.; Park, S.; Park, T.; Sa, D. H.; Seok, C.; Song, M. Y.; Won, J.; Woo, H.; Yang, J.
10.1101/2025.03.09.642274 — bioengineering — Posted on 2025-03-13
3206 AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve Efficacy
Wang, H.; Xia, C.; Zhu, Y.; Wang, Y.; Chu, X.; Pan, X.; Zhou, H.; Lu, Z.; Patrick, D.; Li, Y.; Long, Y.; Yu, Q.
10.1101/2025.03.09.641110 — bioengineering — Posted on 2025-03-13
3210 A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis
de Carvalho, E.; Amin, A.; LiIttle, R.; Silva, K. F.; Gaspar, C.; Badenes, M.; Burbridge, E.; Paixao, T.; Amorim, M. J.; Faisca, P.; Fischer, R.; Vendrell, I.; O'Brien, D. P.; Strisovsky, K.; Christianson, J. C.; Domingos, P.; Adrain, C.
10.1101/2025.03.10.642408 — biochemistry — Posted on 2025-03-13
3214 Above-Filter Digestion Proteomics reveals drug targets and localizes ligand binding site
Sokolova, B.; Gharibi, H.; Jafari, M.; Lyu, H.; Lovera, S.; Gaetani, M.; Saei, A. A.; Zubarev, R.
10.1101/2025.03.11.642584 — biochemistry — Posted on 2025-03-13
3215 Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis
Strefeler, A.; Baker, Z. N.; Chollet, S.; Guerra, R. A.; Ivanisevic, J.; Gallart-Ayala, H.; Pagliarini, D. J.; Jourdain, A. A.
10.1101/2025.03.11.642569 — biochemistry — Posted on 2025-03-13
3216 An optimized SP3 sample processing workflow for in-depth and re-producible phosphoproteomics
Daly, L. A.; Clarke, C. J.; Oswald, S. O.; Jankevics, A.; Brownridge, P.; Scheltema, R. A.; Eyers, C. E.
10.1101/2025.03.13.643088 — biochemistry — Posted on 2025-03-13
3217 An extensive and unbiased genome-wide scan for parent-of-origin expressed genes in the pig clarifies the conservation landscape of genomic imprinting
Perret, M.; Iannuccelli, N.; Leroux, S.; Feve, K.; Dehais, P.; Jacomet, E.; Hubert, J.-N.; Iampetro, C.; Vandecasteele, C.; Maman, S.; Faraut, T.; Liaubet, L.; Bonnet, A.; Donnadieu, C.; Riquet, J.; Demars, J.
10.1101/2025.03.09.642261 — genomics — Posted on 2025-03-13
3218 Multi-millennial genetic resilience of Baltic diatom populations disturbed in the past centuries
Schmidt, A.; Bolius, S.; Chagas, A.; Romahn, J.; Kaiser, J.; Arz, H. W.; Balint, M.; Kremp, A.; Epp, L. S.
10.1101/2025.03.10.642313 — genomics — Posted on 2025-03-13
3219 Comprehensive profiling of N6-methyladnosine (m6A) readouts reveals novel m6A readers that regulate human embryonic stem cell differentiation
Huang, Z.; Liu, R.; Wubulikasimu, Z.; Zhao, W.; Huang, J.; Wang, J.; Fan, R.; Kong, W.; Cui, Q.; Li, Y.; Zhou, Y.
10.1101/2025.03.09.640963 — genomics — Posted on 2025-03-13
3220 Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries
Khan, M. W.; Cruz de Jesus, V.; Mittermuller, B.-A.; Schroth, R. J.; Hu, P.; Chelikani, P.
10.1101/2025.03.10.642456 — genomics — Posted on 2025-03-13
3224 Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos
Parkinson, J. E.; Baldwin, G. E.; Papotto, P. H.; Humphreys, N. E.; Adamson, A. D.; Allen, J. E.; Sutherland, T. E.
10.1101/2025.03.10.642405 — genetics — Posted on 2025-03-13
3227 From smartphones to satellites: Uniting crowdsourced biodiversity monitoring and Earth observation to fill the gaps in global plant trait mapping
Lusk, D.; Wolf, S.; Svidzinska, D.; Dormann, C. F.; Kattge, J.; Bruelheide, H.; Sabatini, F. M.; Damasceno, G.; Moreno Martinez, A.; Violle, C.; Hending, D.; Hähn, G. J. A.; Tabeni, S.; Phartyal, S.; Goncalves, F.; Kreft, H.; Schmidt, M.; Chen, H.; Güler, B.; Dolezal, J.; Pielech, R.; Guido, A.; Dwyer, C.; Napoleone, F.; Willie, J.; Gasper, A. L.; Macia, M. J.; Chytry, M.; Lenoir, J.; Thakur, D.; Dengler, J.; Swierszcz, S.; Altman, J.; Mucina, L.; Nerlekar, A. N.; Kakinuma, K.; Rawat, P.; Stancic, Z.; Testolin, R.; Hatim, M. Z.; Rodrigues, F.; Homeier, J.; Marques, M. C. M.; McCarthy, J. K.;
10.1101/2025.03.10.641660 — ecology — Posted on 2025-03-13
3228 The Agroforestry Species Switchboard, a global resource to explore information for 107,269 plant species
Kindt, R.; Siddique, I.; Dawson, I.; John, I.; Pedercini, F.; Lilleso, J.-P. B.; Graudal, L.
10.1101/2025.03.09.642182 — ecology — Posted on 2025-03-13
3229 Comparison of oviposition and adult trapping to monitor wMel introgression for Wolbachia-based vector control
Nelson, E.; Pereira, T. N.; Ribeiro, E. M. d. C.; Mafra e Silva, B. D.; Camillo, C.; Rodrigues da Costa, T.; Teixeira, M. M.; Ko, A. I.; Cummings, D. A.; Moreira, L. A.
10.1101/2025.03.10.642347 — ecology — Posted on 2025-03-13
3230 Environmental dynamics influence scale cortisol levels in Mexican cavefish
Bauhus, M. B.; Wander, L. C.; Boy, D.; Santacruz, A.; Maldonado, E.; Kurtz, J.; Kaiser, S.; Peuss, R.
10.1101/2025.03.09.642216 — ecology — Posted on 2025-03-13
3231 Delayed recovery of seed-dispersal interactions after deforestation
Landim, A. R.; Albrecht, J.; Brito, J.; Burneo, S.; Erazo, S.; Tinoco, B. A.; Tschapka, M.; Neuschulz, E. L.; Schleuning, M.
10.1101/2025.03.11.641853 — ecology — Posted on 2025-03-13
3232 Charting Postnatal Heart Development Using In Vivo Single-Cell Functional Genomics
WANG, H.; Dong, Y.; Song, Y.; Colon, M.; Yapundich, N.; Rocketts, S.; Liu, X.; Farber, G.; Qian, Y.; Qian, L.; Liu, J.
10.1101/2025.03.10.642473 — developmental biology — Posted on 2025-03-13
3233 LANA-Dependent Transcription-Replication Conflicts and R-Loops at the Terminal Repeats (TR) Correlate with KSHV Episome Maintenance
Asghar, A.; Vladimirova, O.; Sobotka, A.; Hayden, J.; Wickramasinghe, J.; Dheekollu, J.; Minakuchi, M.; Murphy, M. E.; Nishikura, K.; Lieberman, P. M.
10.1101/2025.03.10.642343 — molecular biology — Posted on 2025-03-13
3235 The Arabidopsis deNADding enzyme DXO1 modulates the plant immunity response.
Golisz-Mocydlarz, A.; Zakrzewska-Placzek, M.; Krzyszton, M.; Diachenko, N.; Piotrowska, J.; Kalbarczyk, W.; Marasek-Ciolakowska, A.; Kufel, J.
10.1101/2025.03.11.642587 — molecular biology — Posted on 2025-03-13
3238 RNA Architecture Underlies Discontinuous Transcription and Evolution of Coronavirus
Wen, Z.; Chen, L.; Luo, D.; Sun, J.; Guo, L.; Deng, Y.; Huang, Z.; Wang, Y.; Pan, K.; Wang, F.; Xiao, S.; Li, L.; Wei, D.
10.1101/2025.03.13.642953 — microbiology — Posted on 2025-03-13
3241 UNCONVENTIONAL INTERLEUKIN-1 SIGNALING IN CARDIAC DYSFUNCTION
Toldo, S.; Narayan, P.; Mezzaroma, E.; Ghigo, A.; Damilano, F.; Marchetti, C.; Mauro, A. G.; Hirsch, E.; Van Tassell, B.; Abbate, A.
10.1101/2025.03.09.642166 — immunology — Posted on 2025-03-13
3242 CIRCADIAN MODULATION OF NEUTROPHIL FUNCTION DETERMINES COLLATERAL PERFUSION AND OUTCOME AFTER ISCHEMIC STROKE
Vazquez-Reyes, S.; Garcia-Culebras, A.; Di, G.; Diaz-Benito, B.; de Castro-Millan, F. J.; Ruiz-Sanchez, A.; Merino-Casamayor, E.; Parra-Perez, C.; Nieto-Vaquero, C.; Moraga, A.; Calleja, P.; Dopazo, A.; Alejano, S. C.; Rubio-Ponce, A.; Aroca-Crevillen, A.; Sanchez-Cabo, F.; El Bobakry, S. P.; Torroja, C.; Esposito, E.; Lo, E.; Ballesteros, I.; Hidalgo, A.; Cuartero, M. I.; Lizasoain, I.; Moro, M. A.
10.1101/2025.03.09.639714 — immunology — Posted on 2025-03-13
3243 MARCO is an IFN-restricted immunometabolic decoy LPS receptor
Ramani, S.; Cahill, S.; Finnegan, M.; Stine, L.; Shmuel-Galia, L.; Humphries, F.
10.1101/2025.03.10.642106 — immunology — Posted on 2025-03-13
3244 Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors
Brady, A. E.; Revu, S.; Wu, D.; Fisk, H.; Kone, K.; Lydecker, A.; Purser, E. J.; Smith, N. L.; Hilt, Z. T.; Woodyear, S.; Caddy, S.; Gingras, S.; Rudd, B.; McGeachy, M. J.
10.1101/2025.03.10.642460 — immunology — Posted on 2025-03-13
3245 The absent P3a. Performance monitoring ERPs differentiate trust in humans and autonomous systems.
Rogers, D. A.; Brooks, K. J.; Finn, A.; Schlesewsky, M.; Ullsperger, M.; Bornkessel-Schlesewsky, I.
10.1101/2025.03.12.642947 — neuroscience — Posted on 2025-03-13
3246 Human pulvinar stimulation engages select cortical pathways in epilepsy
Bilderbeek, J. A.; Gregg, N. M.; Yanez-Ramos, M. G.; Huang, H.; Montoya, M. M.; Brunner, P.; Willie, J. T.; Van Gompel, J. J.; Worrell, G. A.; Miller, K. J.; Hermes, D.
10.1101/2025.03.11.642694 — neuroscience — Posted on 2025-03-13
3247 Spontaneous eye movements reveal that premotor cortex is involved in human thinking
Pilacinski, A.; Wagner, L.; Besson, G.; Matos, M. J.; Araujo, E.; Klaes, C.
10.1101/2025.03.11.642662 — neuroscience — Posted on 2025-03-13
3249 Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington's disease
da Silva Padilha, M.; Koyuncu, S.; Chabanis, E.; Ryazanov, S.; Leonov, A.; Vilchez, D.; Klein, R.; Giese, A.; Griesinger, C.; Dudanova, I.
10.1101/2025.03.11.642540 — neuroscience — Posted on 2025-03-13
3252 Human insula neurons respond to simple sounds during passive listening
Berger, J. I.; Kawasaki, H.; Banks, M. I.; Kumar, S.; Howard, M. A.; Nourski, K. V.
10.1101/2025.03.12.642819 — neuroscience — Posted on 2025-03-13
3253 The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2+ neurons
Machen, B.; Miller, S.; Xin, A.; Lampert, C.; Assaf, L.; Tucker, J.; Pereira, F.; Loewinger, G.; Beas, S.
10.1101/2025.03.10.642469 — neuroscience — Posted on 2025-03-13
3254 In-vivo optogenetic manipulation approach for gerbil medial nucleus of trapezoid body
Li, B.-Z.; Ridenour, M.; Poleg, S.; Kuruppath, P.; McCullagh, E. A.; Lei, T.; Klug, A.
10.1101/2025.03.10.642510 — neuroscience — Posted on 2025-03-13
3257 Dopamine and calcium dynamics in the nucleus accumbens core during food seeking
Weber, S. J.; Driscoll, G. S.; Beutler, M. M.; Kuhn, H. M.; Westlake, J. G.; Wolf, M. E.
10.1101/2025.03.11.642710 — neuroscience — Posted on 2025-03-13
3258 Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction
Chennupati, R.; Solga-kamp, I.; Yogathasan, V.; Yau Pang, T.; Goetzmann, L.; Kleimann, P.; Temme, S.; Hofer, L.; Stefanski, A.; Lang, A.; Nickenig, G.; Jung, C.; Gerdes, N.; Hosen, M. R.; Kelm, M.
10.1101/2025.03.10.642191 — physiology — Posted on 2025-03-13
3261 Cellular characterization of the peritumoral brain zone of glioblastomas: heterogenous nature and clinical relevance.
deDios, O.; Romero, J.; Ramirez-Gonzalez, M.; Herranz-Sanchez, B.; Avis, A.; Ramos, A.; Sepulveda-Sanchez, J. M.; Gargini, R.; Melendez, B.; Gonzalez, P.; Jimenez-Roldan, L.; Garcia-Posadas, G.; Hernandez-Lain, A.; Perez-Nunez, A.; Sanchez-Gomez, P.
10.1101/2025.03.09.633849 — cancer biology — Posted on 2025-03-13
3262 The effect of cold ischemia time on hypoxia, EMT, and apoptosis pathways in normal colon mucosa
Duzowska, K.; Filipowicz, N.; Opiełka, M.; Drezek-Chyła, K.; Kostecka, A.; Horbacz, M.; Skokowski, J.; Rostkowska, O.; Kobiela, J.; Kalinowski, L.; Dumanski, J. P.; Piotrowski, A.; Jakalski, M.
10.1101/2025.03.09.642255 — cancer biology — Posted on 2025-03-13
3263 Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas
Ali, H.; Zhou, N.; Chen, L.; Hijfte, L. v.; Karri, V.; Zhou, Y.; Habashy, K.; Arrieta, V. A.; Kim, K.-S.; Duffy, J.; Yeeravalli, R.; Tiek, D.; Song, X.; Mishra, S.; Lee-chang, C.; Ahmed, A. U.; Heiland, D. H.; Sonabend, A. M.; Dmello, C.
10.1101/2025.03.09.642289 — cancer biology — Posted on 2025-03-13
3265 Patterned illumination enables denser deep-learning based single-molecule localization microscopy
Smith, C.; Kapitein, L.; Dekker, N.; Hung, S.-T.; Fan, D.; Passmore, J. B.; Cnossen, J.
10.1101/2025.03.09.642203 — biophysics — Posted on 2025-03-13
3274 Chimeric Collagen-like Proteins with Tunable Structural Heterogeneity for Precise Control and Targeted Doxorubicin Delivery
Xia, Y.; Li, Y.; Huang, J.; Feng, J.; Li, J.; Liu, C.; Jia, S.; Man, S.; Li, S.; Wu, R.; Ren, Z.; Zang, Y.; Wang, L.; Liu, X.; Wang, J.; Sun, Y.; Wang, L.; Li, X.
10.1101/2025.03.09.641987 — bioengineering — Posted on 2025-03-13
3279 The sialome of the retina, alteration in age-related macular degeneration (AMD) pathology and potential impacts on Complement Factor H
Swan, J.; Toomey, C. B.; Bergstrand, M.; Cuello, H. A.; Robie, J.; Yu, H.; Yuan, Y.; Kooner, A. S.; Chen, X.; Shaughnessy, J.; Ram, S.; Varki, A.; Gagneux, P.
10.1101/2025.03.09.642149 — biochemistry — Posted on 2025-03-13
3285 Quantifying the effects of antibiotic resistance and within-host competition on strain fitness in Streptococcus pneumoniae
Krishna, A.; Tonkin-Hill, G.; Morel-Journel, T.; Bentley, S.; Turner, P.; Blanquart, F.; Lehtinen, S.
10.1101/2025.03.09.642042 — ecology — Posted on 2025-03-13
3289 Generation and Characterization of Col6a1 knock-in mice: A Promising Pre-Clinical Model for Collagen VI-Related Dystrophies
Lopez-Marquez, A.; Badosa, C.; Enjuanes, L.; Hernandez-Carabias, P.; Sanchez-MartIn, M. A.; Cadot, B.; Guesmia, Z.; Georvasilis, I.; Balsells, S.; Blanco-Ramos, M.; Puighermanal, E.; Quintana, A.; Roldan, M.; Allamand, V.; Jimenez-Mallebrera, C.
10.1101/2025.03.11.642560 — neuroscience — Posted on 2025-03-13
3291 AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy
Ramachandran, S.; Ardinger, J.; Bu, J.; Ramos, M.; Guo, L.; Ghosh, D.; Hossain, M.; Chou, S.-C.; Chen, Y.; Wischof, E.; Ayloo, S.; Trullo, R.; Luo, Y.; Hogestyn, J.; DuBreuil, D.; Crosier, E.; Adams, J.; Richards, A.; Tsabar, M.; Gaglia, G.; Nass, S.; Nambiar, B.; Woodcock, D.; O'Riordan, C.; Tang, Q.; Elmer, B.; Zhang, B.; Goulet, M.; Mueller, C.
10.1101/2025.03.12.642609 — neuroscience — Posted on 2025-03-13
3292 Androgen receptors expressed in the primary sensory neurons regulate mechanical pain sensitivity
Saika, F.; Uta, D.; Fukazawa, Y.; Hino, Y.; Hatano, Y.; Kishioka, S.; Nawa, H.; Hino, S.; Suzuki, K.; Kiguchi, N.
10.1101/2025.03.13.642983 — neuroscience — Posted on 2025-03-13
3294 Spatial flexibility of distractor suppression in the tactile modality
Ignaco, A. S.; Serino, N.; Trzpis, A.; Lalor, E. C.; Gomez-Ramirez, M.
10.1101/2025.03.10.642407 — neuroscience — Posted on 2025-03-13
3295 PARylation in Parkinson's disease: a bridge between Lewy body formation and neuronal cell death
Novello, C.; Giampietro, F.; Calogero, A. M. E.; Giaccone, G.; Salemi, M.; Bramerio, M.; Bonoldi, E.; Calandrella, D.; Contaldi, E.; Isaias, I. U.; Rolando, C.; Pezzoli, G.; Cappelletti, G.; Mazzetti, S.
10.1101/2025.03.12.642849 — neuroscience — Posted on 2025-03-13
3298 Propofol differentially modulates consolidation of schema-congruent and -incongruent memory
Risse, L.; Iggena, D.; Landerer, L.; Menk, M.; Olze, H.; Salchow, D.; Finke, C.; Shing, Y. L.; Ploner, C. J.
10.1101/2025.03.13.643087 — neuroscience — Posted on 2025-03-13
3299 Distinguish risk genes functioning at presynaptic or postsynaptic regions and key connectomes associated with pathological α-synuclein spreading
Li, Y.; Torok, J.; Ding, J.; Wang, N.; Lau, C.; Kulkarni, S.; Anand, C.; Tran, J.; Cheng, M.; Lo, C.; Lu, B.; Sun, Y.; Yang, X.; Raj, A.; Peng, C.
10.1101/2025.03.11.642462 — neuroscience — Posted on 2025-03-13
3300 A robust and comprehensive quality control of cerebral cortical organoids: methodology and validation
Castiglione, H.; Madrange, L.; Baquerre, C.; Maisonneuve, B.; Deslys, J.-P.; Yates, F.; Honegger, T.; Rontard, J.; Vigneron, P.-A.
10.1101/2025.03.13.642794 — neuroscience — Posted on 2025-03-13
3307 Visual and vestibular reweighting after cyber- and space-sickness
Bonnard, T.; Doat, E.; Cazalets, J.-R.; Guehl, D.; Guillaud, E.
10.1101/2025.03.12.642770 — neuroscience — Posted on 2025-03-13
3309 Sub-second Fluctuation between Top-Down and Bottom-Up Modes Distinguishes Diverse Human Brain States
Park, Y.; Cha, Y.; Kim, H.; Kim, Y.; Woo, J. H.; Cho, H.; Mashour, G. A.; Xu, T.; Lee, U.; Hong, S.-J.; Honey, C.; Moon, J.-Y.
10.1101/2025.03.12.642768 — neuroscience — Posted on 2025-03-13
3317 Beyond beta: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study
Gerster, M.; Waterstraat, G.; Binns, T. S.; Darcy, N.; Wiest, C.; Koehler, R. M.; Vanhoecke, J.; West, T. O.; Sure, M.; Todorov, D.; Radzinski, L.; Krause, P.; Faust, K.; Schneider, G.-H.; Ashkan, K.; Pereira, E.; Akram, H.; Zrinzo, L.; Blankertz, B.; Villringer, A.; Tan, H.; Hirschmann, J.; Kuehn, A. A.; Florin, E.; Schnitzler, A.; Oswal, A.; Litvak, V.; Neumann, W.-J.; Curio, G.; Nikulin, V.
10.1101/2025.03.11.642600 — neuroscience — Posted on 2025-03-13
3320 Adaptive learning via BG-thalamo-cortical circuitry
He, Q.; Scott, D. N.; Frank, M. J.; Calderon, C. B.; Nassar, M. R.
10.1101/2025.03.13.643078 — neuroscience — Posted on 2025-03-13
3328 Spatial ploidy inference using quantitative imaging
Russell, N. J.; Belato, P. B.; Oliver, L. S.; Chakraborty, A.; Roeder, A. H. K.; Fox, D. T.; Formosa-Jordan, P.
10.1101/2025.03.11.642217 — developmental biology — Posted on 2025-03-13
3331 Tuft dendrites in frontal motor cortex enable flexible learning
Maristany de las Casas, E.; Killmann, K.; Drueke, M.; Muenster, L.; Ebner, C.; Sachdev, R.; Jaeger, D.; Larkum, M. E.
10.1101/2025.03.13.642781 — neuroscience — Posted on 2025-03-13
3332 Optimal positioning and size of high-density electrocorticography grids for speech brain-computer interfaces
Offenberg, E. C.; Berezutskaya, J.; Müller, L.; Freudenburg, Z. V.; Ramsey, N. F.; Vansteensel, M. J.
10.1101/2025.03.13.643127 — neuroscience — Posted on 2025-03-13
3334 Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits
Frroku, L.; Jia, S.; Aleshin, S.; Makesh, S.; Boehm, K.; Alo, A.; Fiebig, T.; Gerardy-Schahn, R.; Fendt, M.; Thiesler, H.; Dityatev, A.
10.1101/2025.03.13.643031 — neuroscience — Posted on 2025-03-13
3337 Establishment of a second-generation transgenic marmoset model of polyglutamine disease recapitulating neurological symptoms and pathology
Minakawa, E. N.; Owari, K.; Nogami, N.; Nakatani, T.; Koizumi, M.; Kawanobe, A.; Saga, Y.; Kudo, M.; Noguchi, S.; Hanakawa, T.; Hori, Y.; Numazawa, H.; Takeuchi, T.; Katakai, Y.; Saito, R.; Nagai, Y.; Saito, Y.; Tomioka, I.; Seki, K.
10.1101/2025.03.12.642922 — neuroscience — Posted on 2025-03-13
3338 Astroglial TNFR2 signaling regulates hippocampal synaptic function and plasticity in a sex dependent manner
Carney, B. N.; Illiano, P.; Pohl, T. M.; Desu, H. L.; Mudalegundi, S.; Asencor, A. I.; Jwala, S.; Ascona, M. C.; Singh, P. K.; Titus, D. J.; Pazarlar, B. A.; Wang, L.; Bianchi, L.; Mikkelsen, J. D.; Atkins, C. M.; Lambertsen, K. L.; Brambilla, R.
10.1101/2025.03.13.643110 — neuroscience — Posted on 2025-03-13
3340 Tau-Associated Neuronal Loss in the Intermediate Nucleus of the Human Hypothalamus (VLPO Analog): Unveiling the Basis of NREM Sleep Dysfunction in PSP and Alzheimer's Disease
Rastegar-Pouyani, S.; Lew, C.; Pereira, F.; Satpati, A.; Paes, V.; Leite, R. P.; Suemoto, C.; Spina, S.; Seeley, W. W.; Walsh, C.; Neylan, T.; Grinberg, L. T.
10.1101/2025.03.11.642707 — neuroscience — Posted on 2025-03-13
3343 Overlooked features lead to divergent neurobiological interpretations of brain-based machine learning biomarkers
Adkinson, B. D.; Rosenblatt, M.; Sun, H.; Dadashkarimi, J.; Tejavibulya, L.; Horien, C.; Westwater, M. L.; Noble, S.; Scheinost, D.
10.1101/2025.03.12.642878 — neuroscience — Posted on 2025-03-13
3344 Hyperplastic Growth, Not Hydrostatic Distension, in Endolymphatic Hydrops in Humans Challenges the Classic View of Meniere's Disease
Bryton, C.; Correa, D. M.; Baechinger, D.; Fankhauser, V.; Kamber, N. C.; Zhu, M.; O'Malley, J. T.; Hickman, T. T.; Robles-Bolivar, P.; Rauch, S. D.; Eckhard, A. H.
10.1101/2025.03.11.642574 — neuroscience — Posted on 2025-03-13
3350 Melatonin Enhances Sleep via MT1-Driven Activation of Slo1 in Suprachiasmatic Nucleus Neurons
Wang, Z.-W.; Vedantham, K.; Ahmad, A.; Niu, L.-G.; Shui, Y.; Lemtiri-Chlieh, F.; Kaback, D.; Ma, X.-M.; Yee, S.-P.
10.1101/2025.03.12.642893 — neuroscience — Posted on 2025-03-13
3351 C. elegans food choice exhibits effort discounting-like behavior
Millet, J. R. M.; Faumont, S.; Schatz, A. B.; White, A. M.; Chicas-Cruz, K. D.; Lockery, S.
10.1101/2025.03.10.641934 — animal behavior and cognition — Posted on 2025-03-13
3354 The age-related susceptibility to postoperative delirium quantified by bispectral electroencephalography (BSEEG) correlates with postoperative delirium-like behavior in mice
Nishiguchi, T.; Yamanishi, K.; Shimura, A.; Seki, T.; Ishii, T.; Aoyama, B.; Gorantla, N.; Nguyen, H. D.; Phuong, N. J.; Yamanashi, T.; Iwata, M.; Shinozaki, G.
10.1101/2025.03.10.642417 — animal behavior and cognition — Posted on 2025-03-13
3356 EGFR-Mediated Mechanotransduction in Aortic Valve Cells: A Key Pathway in Response to Wall Shear Stress
Gaste, A.; Marchese, D.; Faucherre, A.; Lopez, L.; Bertrand, E.; THERON, A.; Herbane, M.; Seddik, A.; Jopling, C.; Avierinos, J.-F.; Ait Oufella, H.; Deplano, V.; Zaffran, S.
10.1101/2025.03.10.642402 — developmental biology — Posted on 2025-03-13
3357 A transcriptional clock of the human pluripotency transition
Coussement, L.; Ciarchi, M.; Kolmogorova, A.; De Meyer, T.; Rulands, S.; Reik, W.; Rostovskaya, M.
10.1101/2025.03.13.643129 — developmental biology — Posted on 2025-03-13
3360 A versatile information retrieval framework for evaluating profile strength and similarity
Kalinin, A. A.; Arevalo, J.; Vulliard, L.; Serrano, E.; Tsang, H.; Bornholdt, M.; Munoz, A. F.; Sivagurunathan, S.; Rajwa, B.; Carpenter, A. E.; Way, G. P.; Singh, S.
10.1101/2024.04.01.587631 — bioinformatics — Posted on 2025-03-13
3361 Mechanisms that regulate the C1-C2B mutual inhibition controls functional switch of UNC-13
Liu, H.; Li, L.; Wang, J.; Hu, J.; Xia, J.; Yu, X.; Liu, H.; Yang, X.; Ma, C.; Kang, L.; Hu, Z.
10.1101/2024.08.12.607578 — neuroscience — Posted on 2025-03-13
3362 Longer scans boost prediction and cut costs in brain-wide association studies
Ooi, L. Q. R.; Orban, C.; Zhang, S.; Nichols, T. E.; Tan, T. W. K.; Kong, R.; Marek, S.; Dosenbach, N. U. F.; Laumann, T.; Gordon, E. M.; Yap, K. H.; Ji, F.; Chong, J. S. X.; Chen, C.; An, L.; Franzmeier, N.; Roemer, S. N.; Hu, Q.; Ren, J.; Liu, H.; Chopra, S.; Cocuzza, C. V.; Baker, J. T.; Zhou, J. H.; Bzdok, D.; Eickhoff, S. B.; Holmes, A. J.; Thomas Yeo, B. T.; Alzheimers Disease Neuroimaging Initiative,
10.1101/2024.02.16.580448 — neuroscience — Posted on 2025-03-13
3364 Advancing the global statistical standard for urban ecosystem accounts
Babi Almenar, J.; Cortinovis, C.; Vallecillo, S.; Geneletti, D.; Czucz, B.; Marando, F.; Zulian, G.; Addamo, A. M.; La Notte, A.; Casagrandi, R.
10.1101/2025.03.05.641195 — ecology — Posted on 2025-03-13
3366 Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling
Comstock, W. J.; Navarro, M. V.; Maybee, D. V.; Rho, Y.; Wagner, M.; Wang, Y.; Smolka, M. B.
10.1101/2024.12.16.628391 — molecular biology — Posted on 2025-03-13
3371 The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation
Romani, F.; Bonter, I.; Rebmann, M.; Takahashi, G.; Guzman-Chavez, F.; De Batte, F.; Hirakawa, Y.; Haseloff, J.
10.1101/2025.03.12.642684 — plant biology — Posted on 2025-03-13
3372 SPOROCYTELESS/NOZZLE acts together with MADS-domain transcription factors to regulate an auxin-dependent network controlling the Megaspore Mother Cell development
Cavalleri, A.; Astori, C.; Manrique, S.; Bruzzaniti, G.; Smaczniak, C.; Mizzotti, C.; Ruiu, A.; Spano, M.; Movilli, A.; Gregis, V.; Xu, X.; Kaufmann, K.; Colombo, L.
10.1101/2025.03.11.641985 — plant biology — Posted on 2025-03-13
3373 The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulation
Tithi, T. I.; Mo, J.; Borcherding, N.; Jo, S.; Cho, E.; Cash, K. E.; Honda, M.; Wang, L.; Ahmed, K. K.; Shirlekar, K.; Chen, L.; Weigel, R.; Kates, H.; Gibson-Corley, K.; Spies, M.; kolb, R.; Zhang, W.
10.1101/2023.07.20.549745 — cancer biology — Posted on 2025-03-13
3374 A rapidly prototyped, simple yet versatile dynamic breathing Exposure-on-a-Chip for investigating nanoparticle deposition in the alveoli
Liu, X.; Engur, M.; Yan, C.; Dobree, F.; Najjar, T. M.; Chassat, C.; Chen, M.; Stettler, M. E. J.; Xavier, J.; Bernardino de la Serna, J.
10.1101/2025.03.07.642100 — bioengineering — Posted on 2025-03-13
3375 Structural perspective on the design of selective DYRK1B inhibitors
Grygier, P.; Pustelny, K.; Menezes, F.; Jemiola-Rzeminska, M.; Suder, P.; Dubin, G.; Czarna, A.
10.1101/2022.12.23.521429 — biochemistry — Posted on 2025-03-13
3377 scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution
Hingerl, J. C.; Martens, L. D.; Karollus, A.; Manz, T.; Buenrostro, J. D.; Theis, F. J.; Gagneur, J.
10.1101/2024.09.19.613754 — genomics — Posted on 2025-03-13
3379 KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia
Rezi, C. K.; Frei, A.; Campestre, F.; Boldt, K.; Mary, B.; Fixdahl, A. M.; Petersen, A.-L. W.; Sicot, A.; Berggreen, C. R.; Laplace, J.; Johansen, S. L.; Sorensen, J. K. T.; Chamlali, M.; Berchtold, M. W.; Christensen, S. T.; Anvarian, Z.; May-Simera, H. L.; Pedersen, L. B.
10.1101/2024.03.21.586066 — cell biology — Posted on 2025-03-13
3382 Topographically organized dorsal raphe activity modulates forebrain sensory-motor computations and adaptive behaviors.
Mutlu, A. K.; Serneels, B.; Wiest, C.; Trinh, A.-T.; Bardenhewer, R.; Palumbo, F.; Frisvold, O. B.; Aukrust, I. K. F.; Ostenrath, A. M.; Yaksi, E.
10.1101/2025.03.06.641626 — neuroscience — Posted on 2025-03-13
3383 Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouses hand
Pina Novo, D.; Gao, M.; Fischer, R.; Richevaux, L.; Yu, J.; Barrett, J. M.; Shepherd, G. M. G.
10.1101/2024.12.02.626335 — neuroscience — Posted on 2025-03-13
3384 Covalently linked adenovirus-AAV complexes as a novel platform technology for gene therapy
Collins, L. T.; Beatty, W.; Boucher, P. J.; Moyo, B.; Alves-Bezerra, M.; Hurley, A.; Lagor, W.; Bao, G.; Curiel, D. T.; Lu, Z. H.
10.1101/2024.08.21.609008 — synthetic biology — Posted on 2025-03-13
3387 A pennycress transparent testa 8 knockout mutant has drastic changes in seed coat anatomy and chemical compositions
Ding, X.; Duckworth, S.; Southworth, M.; Gautam, B.; Lipton, A.; Velickovic, D.; Sedbrook, J. C.; Handakumbura, P.
10.1101/2025.03.10.642428 — plant biology — Posted on 2025-03-13
3388 Field-based prediction of sugarcane photosynthesis through environmental inputs
Almeida, R. L.; Martins, T. S.; Magalhaes, J. R.; Pires, R. C. M.; Landell, M. G. A.; Xavier, M. A.; Machado, E. C.; Ribeiro, R.
10.1101/2025.03.11.642581 — plant biology — Posted on 2025-03-13
3389 High-resolution transcriptional atlas of growing maize shoot organs throughout plant development under well-watered and drought conditions
Zhang, J.; Verbraeken, L.; Sprenger, H.; Mertens, S.; Wuyts, N.; Cannoot, B.; De Block, J.; Demuynck, K.; Natran, A.; Maleux, K.; Merchie, J.; Crafts-Brandner, S.; Vogel, J.; Bruce, W.; Inze, D.; Maere, S.; Nelissen, H.
10.1101/2025.03.12.642568 — plant biology — Posted on 2025-03-13
3390 Symptom observation underestimates co-infections: insight from viral and bacterial diseases in rice fields in Burkina Faso
Billard, E.; Bangratz, M.; Kassankogno, A. I.; Saengram, P.; Guigma, A. K.; Cotto, O.; Thebaud, G.; Wonni, I.; Sereme, D.; Poulicard, N.; Cunnac, S.; Hutin, M.; Hebrard, E.; Tollenaere, C.
10.1101/2025.03.11.638810 — plant biology — Posted on 2025-03-13
3391 Priming of retrograde signaling in wheat across multiple natural environments reveal how responses to dynamic stimuli can be integrated to alter yield, yield stability and water productivity
Bowerman, A. F.; Moore, M.; Yadav, A.; Zhang, J.; Mortimer, M. D.; Plskova, Z.; Tee, E. E.; Au, E. K.; Collinge, D. P.; Estavillo, G. M.; Howitt, C. A.; Chan, K. X.; Rebetzke, G. J.; Pogson, B. J.
10.1101/2025.03.10.642515 — plant biology — Posted on 2025-03-13
3401 Maize plant infection by Ustilago maydis is regulated by the Fungal Sulfur Metabolism.
Espinoza-Simon, E.; Torres-Ramirez, N.; Juarez-Montiel, M.; Rios-Castro, E.; Ramirez-Robles, D.; Ortiz-Hernandez, R.; Echeverria-Martinez, O.; Villa-Tanaca, L.; Torres-Quiroz, F.
10.1101/2025.03.13.642974 — biochemistry — Posted on 2025-03-13
3402 Neural Synchrony Links Sensorimotor Cortices in a Network for Facial Motor Control
Vazquez, Y.; Ianni, G. R.; Rassi, E.; Rouse, A. G.; Schieber, M. H.; Yazdani, F.; Prut, Y.; Freiwald, W. A.
10.1101/2025.03.04.641458 — neuroscience — Posted on 2025-03-13
3403 Crocetin and crocin production in plant and bacteria using a CCD4 enzyme from Nyctanthes arbor-tristis.
Morote, L.; Moreno-Gimenez, E.; Lopez-Jimenez, A. J.; Rubio-Moraga, A.; Aragones, V.; Ahrazem, O.; Daros, J. A.; Gomez-Gomez, L.
10.1101/2025.03.13.642995 — plant biology — Posted on 2025-03-13
3406 Targeting dCas9-SunTag to a susceptibility gene promoter is sufficient for CRISPR interference
Lin, Z.-J. D.; Hernandez, G. L.; Stanton, M. K.; Zheng, X.; Gilbert, K. B.; Feng, S.; Ghoshal, B.; Gardiner, J.; Wang, M.; Jacobsen, S. E.; Carrington, J. C.; Bart, R. S.
10.1101/2025.03.11.642632 — plant biology — Posted on 2025-03-13
3408 Cysteine signaling in plant pathogen response
Moormann, J.; Heinemann, B.; Angermann, C.; Koprivova, A.; Armbruster, U.; Kopriva, S.; Hildebrandt, T. M.
10.1101/2025.03.13.642987 — plant biology — Posted on 2025-03-13
3409 Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas.
Jain, N.; Ogbanna, E. C.; Maliga, Z.; Jacobson, C. A.; Zhang, L.; Shih, A. R.; Rosenberg, J. M.; Kalam, H.; Gagne, A.; Solomon, I. H.; Santagata, S.; Sorger, P. K.; Aldridge, B. B.; Martinot, A. J.
10.1101/2025.03.10.642376 — pathology — Posted on 2025-03-13
3420 Functional Impact of Nth-like DNA glycosylase on Mitochondrial Dynamics
Hubers, L.; Skjetne, A. M.; Luna, L.; Lefol, Y.; Lund, S. O.; Wagbo, A. M.; Renaudin, X.; Polster, A.; Berg-Eriksen, A. K.; Naranjo-Galindo, F. J.; Campalans, A.; Visnes, T.; Nilsen, H. L.; Montaldo, N. P.
10.1101/2024.10.10.617535 — cell biology — Posted on 2025-03-13
3421 3,4-hydroxyphenyl lactic acid from Lactiplantibacillus plantarum prevents alcoholic liver injury in mice
Zhang, c. x.; Chen, Y.; huang, s.; Bian, X.; yang, b.; lu, s.; fu, x.; zhao, w.; pan, y.; zhao, s.
10.1101/2025.03.12.642873 — microbiology — Posted on 2025-03-13
3422 Neuroanatomical foundations of social tolerance across macaque species
SILVERE, S.; LAMY, J.; Po, C.; LEGRAND, M.; Sallet, J.; Ballesta, S.
10.1101/2025.03.12.642838 — neuroscience — Posted on 2025-03-13
3423 Foliar gas exchange, morphology, and cannabinoid contents of three hemp varieties in southwest Texas
Sebastian, J. S. V.; Dong, X.; Joshi, M. V.; Jessup, R. W.; Leskovar, D. I.; Baltensperger, D. D.
10.1101/2025.03.09.642247 — plant biology — Posted on 2025-03-13
3424 Impaired methyl recycling induces substantial shifts in sulfur utilization in Arabidopsis
Tremblay, B. J.-M.; Adeel, S. A.; Saechao, M.; Dong, Y.; Andrianasolo, E.; Steele, J. M.; Traa, A.; Yogadasan, N.; Waduwara-Jayabahu, I.; Katzenback, B. A.; Hell, R.; Wirtz, M.; Moffatt, B. A.
10.1101/2025.03.09.642221 — plant biology — Posted on 2025-03-13
3426 Arabidopsis INHIBITOR OF GROWTH 2 (ING2) promotes flowering by regulating NuA4-dependent histone H4 acetylation levels at FT and SOC1 chromatin loci
Barrero-Gil, J.; Mouriz, A.; Piqueras, R.; Tian, Y.; Lopez, J. A.; Vazquez, J.; Crevillen, P.; Jarillo, J. A.; Pineiro, M.
10.1101/2025.03.10.642062 — plant biology — Posted on 2025-03-13
3427 Molecular Cloning, In Silico Analysis and Expression of plasma membrane-associated NAR2 Protein, SaNAR2.2, from Euhalophyte Suaeda altissima
Khramov, D. E.; Konoshenkova, A. O.; Nedelyaeva, O. I.; Rostovtseva, E. I.; Ryabova, A. V.; Volkov, V.; Popova, L. G.
10.1101/2025.03.09.642219 — plant biology — Posted on 2025-03-13
3430 Mapping the magnetoreceptive brain: A 3D digital atlas of the migratory bird Eurasian blackcap (Sylvia atricapilla)
Sirmpilatze, N.; Felder, A.; Abdulazhanova, D.; Schwigon, L.; Haase, K.; Musielak, I.; Margrie, T. W.; Mouritsen, H.; Heyers, D.; Tyson, A. L.; Weiler, S.
10.1101/2025.03.04.641293 — neuroscience — Posted on 2025-03-13
3431 Substrate utilization and cross-feeding synergistically determine microbiome resistance to pathogen invasion
Yang, X.; Yang, T.; Zhang, Z.; Zhang, Y.; Mei, X.; Gao, Y.; Wang, N.; Jiang, G.; Xu, Y.; Shen, Q.; Medema, M. H.; Wei, Z.; Jousset, A.
10.1101/2024.11.04.621791 — ecology — Posted on 2025-03-13
3436 Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay
Olsen, A.-K.; Ma, X.; Zheng, C.; Dahl, H.; Dirven, Y.; Boisen, A. M.; Sharma, A.; Eide, D. M.; Brunborg, G.
10.1101/2024.12.22.624648 — pharmacology and toxicology — Posted on 2025-03-13
3437 ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation
Coleman, O. I.; Sorbie, A.; Riva, A.; von Stern, M.; Kuhls, S.; Selegato, D.; Koehler, N.; Wirbel, J.; Kacprowski, T.; Dunkel, A.; Pauling, J. K.; Plagge, J.; Miedel-Cuadra, D.; Wagner, S.; Chadly, I.; Bierwirth, S.; Peng, T.; Metzler, T.; Schafmayer, C.; Hinz, S.; Roeder, C.; Roecken, C.; Zimmermann, M.; Rosenstiel, P.; Steiger, K.; Jesinghaus, M.; Liebisch, G.; Ecker, J.; Schmidt, C.; Zeller, G.; Janssen, K.-P.; Haller, D.
10.1101/2023.11.03.565267 — cancer biology — Posted on 2025-03-13
3438 CHIEF: An Attention-based Ensemble Learning Framework for Functional Protein Design
Geng, Z.; Wang, Y.; Liu, T.; Tan, A.; Wu, S.; Guo, X.; Li, R.; Hou, X.; Sun, K.; Wu, L.; Cui, Q.; Da, L.; Ma, Z.; Li, H.; Zhang, B.
10.1101/2025.03.07.641005 — bioengineering — Posted on 2025-03-13
3440 Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding
Prakash, M.; Chew, Y.-M.; Ondruskova, D.; Miksatko, J.; Dodokova, A.; Krishnan, A.; Janke, C.; Cross, R. A.; Lansky, Z.; Braun, M.
10.1101/2025.03.12.642813 — cell biology — Posted on 2025-03-13
3441 Synthetic communities of maize root bacteria interact and redirect benzoxazinoid metabolization
Thoenen, L.; Zuest, T.; Pestalozzi, C.; Kreuzer, M.; Mateo, P.; Deslandes, G.; Robert, C.; Bruggmann, R.; Erb, M.; Schlaeppi, K.
10.1101/2025.03.12.642850 — microbiology — Posted on 2025-03-13
3443 Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors
Niederau, P. A.; Weilguny, M. C.; Chamas, S.; Turney, C. E.; Parsons, J.; Rodriguez-Franco, M.; Hoernstein, S. N. W.; Decker, E. L.; Toft Simonsen, H.; Reski, R.
10.1101/2025.02.06.636855 — plant biology — Posted on 2025-03-13
3446 Using Autoregressive-Transformer Model for Protein-Ligand Binding Site Prediction
Pourmirzaei, M.; Alqarghuli, S.; Esmaili, F.; POURMIRZAEIOLIAEI, M.; Rezaei, M.; Xu, D.
10.1101/2025.03.11.642700 — bioinformatics — Posted on 2025-03-13
3447 Fluoxetine Delivery for Wound Treatment Through an Integrated Bioelectronic Device - Pharmacokinetic Parameters and Safety Profile in Swine
Gallegos, A.; Li, H.; Yang, H.-Y.; Villa-Martinez, G.; Bazzi, I.; Sathyanarayanan, S.; Asefifeyzabadi, N.; Baniya, P.; Hee, W. S.; Siadat, M.; Chang, E.; Pasumarthi, S.; Teodorescu, M.; Gomez, M.; Rolandi, M.; Isseroff, R.
10.1101/2025.03.11.642735 — bioengineering — Posted on 2025-03-13
3449 Microbial communities on station and train surfaces in Chennai Metro: Insights into urban transit microbiome
Singh, V. Y.; Gadekar, V. P.; Sasikumar, S.; Lokshanan, R. R. M.; Prithiviraj, B.; Sinha, H.; Raman, K.
10.1101/2025.03.12.642787 — ecology — Posted on 2025-03-13
3450 A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation
Ruiz, A. M. B.; Geng, F.-S.; Pujol, G.; Sanabria, E.; Brethouwer, T.; Castillo, M. A.; Ruiz-Herrera, A.; Tena, J. J.; Bogdanovic, O.
10.1101/2025.03.12.642371 — developmental biology — Posted on 2025-03-13
3451 Anopheles barbirostris in Indonesia: A more complex metapopulation than expected.
Manguin, S.; Tunggul Satoto, T. B.; Ambar Garjito, T.; Shinta, S.; Landi, S.; Frutos, R.
10.1101/2025.03.12.642759 — molecular biology — Posted on 2025-03-13
3453 Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution
Schütze, T. M.; Ditzer, N.; Vangelisti, S.; Kolodziejczyk, A.; Capra, E.; Chiaradia, I.; Peters, J.; Krause, M.; Eugster, C.; Derihaci, R. P.; Birdir, C.; Martin, U.; Wimberger, P.; Long, K. R.; Lancaster, M. A.; Kalebic, N.; Bonev, B.; Albert, M.
10.1101/2025.03.12.642828 — neuroscience — Posted on 2025-03-13
3454 Burnout in nurses and biomarkers of stress, inflammation and neuroplasticity.
Arnetz, B. B.; Iseler, J.; Pena, M.; Evola, N.; vanSchagen, J.; Beck, J. S.; Counts, S. E.; Arble, E.; Arnetz, J. E.
10.1101/2025.03.11.642730 — neuroscience — Posted on 2025-03-13
3455 Dense Longitudinal Precision Neuroimaging of Recovery from Traumatic Brain Injury
Rajesh, A.; Laumann, T. O.; Barch, D.; Kay, B. P.; Meyer, A. C.; Kummer, T. T.; Dosenbach, N. U. F.; Gordon, E. M.
10.1101/2025.03.09.642218 — neuroscience — Posted on 2025-03-13
3456 Prefrontal default-mode network interactions with posterior hippocampus during exploration
Papale, A. E.; Brown, V. M.; Ianni, A.; Hallquist, M. N.; Luna, B.; Dombrovski, A. Y.
10.1101/2025.03.12.642890 — neuroscience — Posted on 2025-03-13
3459 Hair test reveals plasticity of human chronotype
Maier, B.; Pilz, L. K.; Oezcakir, S.; Rahjouei, A.; Abdo, A. N.; de Zeeuw, J.; Kunz, D.; Kramer, A.
10.1101/2025.03.07.641864 — systems biology — Posted on 2025-03-13
3460 p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners
Brdar, A.; Osterburg, C.; Münick, P.; Machel, A. C.; Rathore, R.; Osterburg, S.; Yüksel, B.; Schäfer, B.; Desch, K.; Langer, J. D.; Dikic, I.; Dötsch, V.
10.1101/2024.10.02.616239 — biophysics — Posted on 2025-03-13
3462 Integrating Natural and Engineered Genetic Variation to Decode Regulatory Influence on Blood Traits
Tardaguila, M.; Von Schiller, D.; Colombo, M.; Gori, I.; Coomber, E. L.; Vanderstichele, T.; Benaglio, P.; Chiereghin, C.; Gerety, S. S.; Vuckovic, D.; Landini, A.; Clerici, G.; Albers, P. K.; Ray-Jones, H.; Burnham, K. L.; Tokolyi, A.; Persyn, E.; Spivakov, M.; Sankaran, V. G.; Walter, K.; Kundu, K.; Pirastu, N.; Inouye, M.; Paul, D. S.; Davenport, E.; Sahlen, P.; Watt, S.; Soranzo, N.
10.1101/2024.08.05.606572 — genetics — Posted on 2025-03-13
3464 Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription
Kroeger, B.; Manning, S. A.; Mohan, V.; Deng, Q.; Lou, J.; Sun, G.; Lamont, S.; McCann, A. J.; Francois, M.; Polo, J. M.; Hinde, E.; Harvey, K. F.
10.1101/2025.03.11.642705 — cell biology — Posted on 2025-03-13
3465 Red Light-Activated Reversible Inhibition of Protein Functions by Assembled Trap
Zhou, P.; Jia, Y.; He, X.; Zhang, T.; Liu, C.; Li, W.; Li, Z.; Sun, L.; Guang, S.; Zhou, Z.; Yuan, Z.; Lu, X.; Yu, Y.
10.1101/2025.03.10.642306 — cell biology — Posted on 2025-03-13
3466 Double stranded RNA sensing drives interferon silencing in early development
Witteveldt, J.; Liu, Z.; Ariza-Cosano, A.; Ramirez, C.; Walters, J. L.; Marchante, P. G.; Maas, L.; Ivens, A.; Tebaldi, T.; Heras, S. R.; Marks, H.; Macias, S.
10.1101/2025.03.10.642424 — cell biology — Posted on 2025-03-13
3467 Quantitative profiling of lysosomal accumulation through label-free biomarkers via High-Content Holo-Tomographic Flow Cytometry
Pirone, D.; Schiavo, M.; Giugliano, G.; Montefusco, S.; Miccio, L.; Memmolo, P.; Medina, D. L.; Ferraro, P.
10.1101/2025.03.11.642563 — cell biology — Posted on 2025-03-13
3469 Gut Microbiome-Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal Cells
Powell, C. E.; Dohnalova, L.; Eisert, R. J.; Sun, Z.-Y. J.; Seo, H.-S.; Dhe-Paganon, S.; Thaiss, C. A.; Devlin, A. S.
10.1101/2025.03.10.642513 — cell biology — Posted on 2025-03-13
3470 O-GlcNAc modifications regulate lamin A tail processing
Augspurger, K. R.; Martin, E. A.; Maynard, J.; Welle, K.; Ghaemmaghami, S.; Burlingame, A.; Panning, B.; Buchwalter, A.
10.1101/2025.03.11.642699 — cell biology — Posted on 2025-03-13
3471 AreTomoLive: Automated reconstruction of comprehensively-corrected and denoised cryo-electron tomograms in real-time and at high throughput
Peck, A.; Yu, Y.; Paraan, M.; Kimanius, D.; Ermel, U. H.; Hutchings, J.; Serwas, D.; Siems, H.; Hill, N. S.; Ali, M.; Peukes, J.; Greenan, G. A.; Sheu, S.-H.; Montabana, E. A.; Carragher, B.; Potter, C. S.; Agard, D. A.; Zheng, S.
10.1101/2025.03.11.642690 — cell biology — Posted on 2025-03-13
3472 FOSL2 Directly Regulates FSHR and CYP11A1 Transcription: An Essential Transcription Factor for Gonadotropin-Dependent Folliculogenesis
Shi, H.; Chen, C.; Ran, Z.; Liao, J.; Wu, Z.; Wang, X.; Zhao, Y.; Ke, W.; Tan, B.; Liu, Y.; Ren, W.; Li, X.; He, C.
10.1101/2025.03.11.642212 — cell biology — Posted on 2025-03-13
3473 Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding
Prakash, M.; Chew, Y.-M.; Ondruskova, D.; Miksatko, J.; Dodokova, A.; Krishnan, A.; Janke, C.; Cross, R. A.; Lansky, Z.; Braun, M.
10.1101/2025.03.12.642813 — cell biology — Posted on 2025-03-13
3474 Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells
Chiquetto, L.; Schuetz, M.; Dong, Q.; Warmka, M.; Valin, L.; Jones, A.; Hunt, P.; Petermeier, C.; Wang, J.; Roundy, N.; Greenberg, Z.; Yang, W.; Zhang, C.; Challen, G.; Luke, C.; Signer, R.; Beatty, W.; Sykes, S.; Li, W.; Kast, D.; Schuettpelz, L.
10.1101/2025.03.10.642434 — cell biology — Posted on 2025-03-13
3476 WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
Wilson, J. C. J.; Zhu, J.; Lam, S.; Hart, A.; Goh, C. G.; Bou-Dagher, F.; Razumkov, H.; Kobel, L.; Kontarakis, Z.; Fieldin, J.; Schlapansky, M. F.; Loizou, J. I.; Villunger, A.; Corn, J. E.; Marciniak, S. J.; Bader, A. S.; Jackson, S. P.
10.1101/2025.03.12.642825 — cancer biology — Posted on 2025-03-13
3477 Biological volume EM with focused Ga ion beam depends on formation of radiation-resistant Ga-rich layer at block face
Yang, Z.; Kim, J.; Baenen, C. M.; Fulton, S. J.; Zhang, G.; Chen, X.; Aronova, M. A.; Leapman, R. D.
10.1101/2024.09.16.613321 — biophysics — Posted on 2025-03-13
3478 Benchmarking porcine pancreatic ductal organoids for drug screening applications
Karampelias, C.; Yang, K.; Sterr, M.; Molina van Den Bosch, M.; Renner, S.; Fuss, J.; Franzenburg, S.; Kin, T.; Wolf, E.; Kemter, E.; Lickert, H.
10.1101/2025.03.12.642843 — developmental biology — Posted on 2025-03-13
3479 Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders
Njeim, R.; Awada, B.; Donow, H.; Gye, H.; Foster, C.; Kelly, C.; Molina, J.; Merscher, S.; Giulianotti, M.; Fornoni, A.; Al-Ali, H.
10.1101/2025.03.11.642628 — cell biology — Posted on 2025-03-13
3480 A Chlorinated Diketopiperazine Antibiotic Targets Mycobacterium Tuberculosis DNA Gyrase
Liang, L.; Quigley, J.; Theriault, M.; Iinishi, A.; Bargabos, R.; Morrissette, M.; Ghiglieri, M. L.; Curtis, T.; Corsetti, R.; Son, S.; Sarkar, B.; Lewis, K.
10.1101/2025.03.10.642354 — cell biology — Posted on 2025-03-13
3481 Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device
Jung, T.; Zeng, N.; Fabbri, J. D.; Eichler, G.; Li, Z.; Zabeh, E.; Das, A.; Willeke, K.; Wingel, K. E.; Dubey, A.; Huq, R.; Sharma, M.; Hu, Y.; Ramakrishnan, G.; Tien, K.; Mantovani, P.; Parihar, A.; Yin, H.; Oswalt, D.; Misdorp, A.; Uguz, I.; Shinn, T.; Rodriguez, G. J.; Nealley, C.; Gonzales, I.; Roukes, M.; Knecht, J.; Yoshor, D.; Canoll, P.; Spinazzi, E.; Carloni, L. P.; Pesaran, B.; Patel, S.; Jacobs, J.; Youngerman, B.; Cotton, R. J.; Tolias, A.; Shepard, K. L.
10.1101/2024.05.17.594333 — neuroscience — Posted on 2025-03-12
3483 A cardiac microphysiological system for screening lipid nanoparticle/mRNA complexes predicts in vivo efficacy for heart transfection
Neiman, G.; Costa, M. W.; Han, H.; Zhao, S.; Ng, T.; Siemons, B.; Nishino, T.; Huang, Y.; Lal, S.; Wu, K.; Judge, L.; Conklin, B.; Srivastava, D.; Murthy, N.; Healy, K. E.
10.1101/2025.03.07.642075 — bioengineering — Posted on 2025-03-12
3484 CHIEF: An Attention-based Ensemble Learning Framework for Functional Protein Design
Geng, Z.; Wang, Y.; Liu, T.; Tan, A.; Wu, S.; Guo, X.; Li, R.; Hou, X.; Sun, K.; Wu, L.; Cui, Q.; Da, L.; Ma, Z.; Li, H.; Zhang, B.
10.1101/2025.03.07.641005 — bioengineering — Posted on 2025-03-12
3485 Unveiling Hidden Microbial Diversity in Mars 2020 Mission Assembly Cleanrooms with Molecular Insights into the Persistent and Perseverance of Novel Species Defying Metagenome Sequencing
Muthamilselvi Sivabalan, S. K.; Vijayakumar, V.; Sengupta, P.; Palmal, S.; Krishnamurthi, S.; Kumar Singh, N.; Kyrpides, N. C.; Raman, K.; Venkateswaran, K.
10.1101/2025.01.21.633868 — genomics — Posted on 2025-03-12
3488 The Masc-PSI complex directly induces male-type doublesex splicing in silkworms
Kaneda, T.; Matsuda-Imai, N.; Kosako, H.; Shoji, K.; Suzuki, M. G.; Suzuki, Y.; Kiuchi, T.; Katsuma, S.
10.1101/2025.03.07.642132 — molecular biology — Posted on 2025-03-12
3490 Widespread mono- and oligoadenylation direct small noncoding RNA maturation versus degradation fates
Ocheltree, C.; Skrable, B.; Pimentel, A.; Nicholson-Shaw, T.; Lee, S. R.; Lykke-Anderson, J.
10.1101/2025.01.31.635978 — molecular biology — Posted on 2025-03-12
3491 Vaginal microbiota changes during a natural menstrual cycle in the Women4Health cohort highlights specific features of the Italian population.
Vinerbi, E.; Chillotti, F.; Maschio, A.; Lenarduzzi, S.; Camarda, S.; Crobu, F.; Zhernakova, D. V.; Lo Faro, V.; Beltrame Vriz, G.; Incollu, S.; Spreckels, J. E.; Kuzub, N.; Kadric, A.; Gacesa, R.; Zhernakova, A.; De Seta, F.; Mazza, D.; Busonero, F.; Ferrando, M. L.; Girotto, G.; Sanna, S.
10.1101/2025.03.12.642767 — microbiology — Posted on 2025-03-12
3493 Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors
Bailey, R.; Kahoekapu, K.; To, A.; Mayerlen, L.; Kae, H.; Manninen, G.; Haun, B. K.; Berestecky, J.; Shikuma, C.; Lehrer, A. T.; MacPherson, I. S.
10.1101/2025.03.07.642120 — immunology — Posted on 2025-03-12
3496 The mRNA covalent modification dihydrouridine positively impacts photosynthesis-associated genes in field-grown drought-stressed sorghum
Yu, L.; Melandri, G.; Dittrich, A. C.; Calleja, S.; Rozzi, B.; Palos, K.; Srinivasan, A.; Brewer, E. K.; Fischer, H.; Obata, T.; Elgawad, H. A.; Beemster, G. T. S.; Henderson, R.; Garcia, C. D.; Zhang, X.; Stern, D.; Eveland, A.; Schroeder, S. J.; Skirycz, A.; Lyons, E.; Arnold, E. A.; Gregory, B. D.; Nelson, A. D. L.; Pauli, D.
10.1101/2025.01.17.633510 — plant biology — Posted on 2025-03-12
3498 PRAME Epitopes are T-Cell Immunovulnerabilities in BRD4::NUTM1 Initiated NUT Carcinoma
Jensen, J. L.; Peterson, S. K.; Yu, S.; Kinjo, T.; Price, B. A.; Sambade, M.; Vesko, S.; DeBetta, J. D.; Geyer, J. K.; Nickel, K. P.; Kimple, R. J.; Kotecha, R. S.; Davis, I. J.; Wang, J. R.; French, C. A.; Kuhlman, B.; Rubinsteyn, A.; Weiss, J.; Vincent, B. G.
10.1101/2025.03.07.642090 — cancer biology — Posted on 2025-03-12
3503 Heterobifunctional proteomimetic polymers for targeted protein degradation
Wang, M. M.; Truica, M. I.; Gattis, B.; Oktawiec, J.; Sagar, V.; Basu, A.; Bertin, P.; Zhang, X.; Abdulkadir, S.; Gianneschi, N.
10.1101/2025.03.07.641543 — bioengineering — Posted on 2025-03-12
3505 A rapidly prototyped, simple yet versatile dynamic breathing Exposure-on-a-Chip for investigating nanoparticle deposition in the alveoli
Liu, X.; Engur, M.; Yan, C.; Dobree, F.; Najjar, T. M.; Chassat, C.; Chen, M.; Stettler, M. E. J.; Xavier, J.; Bernardino de la Serna, J.
10.1101/2025.03.07.642100 — bioengineering — Posted on 2025-03-12
3507 ADAR1 regulates alternative splicing through an RNA editing-independent mechanism.
Sagredo, E. A.; Karlstrom, V.; Blanco, A.; Moraga, P.; Vergara, M.; Jarvelin, A. I.; Visa, N.; Marcelain, K.; Castello, A.; Armisen, R.
10.1101/2025.03.12.642916 — molecular biology — Posted on 2025-03-12
3510 Intratumoral Resident Microbes Directly Participate in Resistance to EGFR-TKI Targeted Drug Therapy through Metabolism in NSCLC
Wang, H.; Zhang, J.; Zhang, J.; Hou, W.; Zhou, J.; Li, M.; Liu, X.; Li, Y.; Fu, F.; Tian, P.; Li, W.; Liu, D.; Xie, D.
10.1101/2025.03.12.642829 — microbiology — Posted on 2025-03-12
3511 Persistent viral infections impact key biological traits in Drosophila melanogaster
Castello-Sanjuan, M.; Gonzalez, R.; Romoli, O.; Blanc, H.; Nigg, J.; Saleh, M.-C.
10.1101/2025.03.12.642769 — microbiology — Posted on 2025-03-12
3512 A central, shared role for disulfide bonds in Bacteroidota protein transport and gliding motility
Liu, X.; Avramova, M.; Deme, J. C.; Jones, R. L.; Lundgren, C. A.; Lea, S. M.; Berks, B. C.
10.1101/2025.03.12.642685 — microbiology — Posted on 2025-03-12
3513 A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape
Isaacs, A.; Valenzuela Nieto, G.; Zhang, X.; Modhiran, N.; Barr, J.; Thakur, N.; Low, Y. S.; Parry, R.; Barnes, J. B.; Jara, R.; Himelreichs, J.; Yao, Y.; Deride, C.; Barthou-Gatica, B.; Salinas-Rebolledo, C.; Pamela, E.; Hen, J. J.; Hayes, N.; Paramitha, D.; Morgan, M. S.; McMillan, C. L.; Jones, M. L.; Munro, T.; Khromykh, A.; Reading, P.; Young, P.; Chappell, K.; Shi, Y.; Bailey, D.; Marsh, G. A.; Chiu, S.; Rojas-Fernandez, A.; Watterson, D.
10.1101/2025.03.11.642517 — microbiology — Posted on 2025-03-12
3515 Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer
Liu, M.; Hernandez, M.; Castven, D.; Lee, H.-P.; Wu, W.; Wang, L.; Forgues, M.; Hernandez, J.; Marquardt, J.; Ma, L.
10.1101/2025.03.07.642107 — cancer biology — Posted on 2025-03-12
3518 Influenza virus antagonizes self sensing by RIG-I to enhance viral replication
Ledwith, M. P.; Nipper, T.; Davis, K. A.; Uresin, D.; Komarova, A. V.; Mehle, A.
10.1101/2025.03.12.642847 — microbiology — Posted on 2025-03-12
3519 Synthetic communities of maize root bacteria interact and redirect benzoxazinoid metabolization
Schlaeppi, K.; Thoenen, L.; Zuest, T.; Pestalozzi, C.; Kreuzer, M.; Mateo, P.; Deslandes, G.; Robert, C.; Bruggmann, R.; Erb, M.
10.1101/2025.03.12.642850 — microbiology — Posted on 2025-03-12
3522 Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein Expression
Almey, R.; Mwangi, K.; De Cae, S.; Ramasamy, P.; Van Hulle, M.; Lentacker, I.; Schepens, B.; Deforce, D.; Martens, G.; Ramaut, P.; Vissers, J. P.; Saelens, X.; Verbeke, R.; Dhaenens, M.; Van Puyvelde, B. R.
10.1101/2025.03.11.642564 — immunology — Posted on 2025-03-12
3524 Cholecystokinin modulates age-dependent Thalamocortical Neuroplasticity
Li, X.; Feng, J.; Hu, X.; Zhou, P.; Chen, T.; Zheng, X.; Jendrichovsky, P.; Chen, X.; Wang, X.; Chen, M.; Li, H.; Zeng, D.; Zhang, M.; Xiao, Z.; He, L.; Bello, S. T.; He, J.
10.1101/2024.07.31.605964 — neuroscience — Posted on 2025-03-12
3525 Precise Spatial Tuning of Visually Driven Alpha Oscillations in Human Visual Cortex
Yuasa, K.; Groen, I. I. A.; Piantoni, G.; Montenegro, S.; Flinker, A.; Devore, S.; Devinsky, O.; Doyle, W.; Dugan, P.; Friedman, D.; Ramsey, N.; Petridou, N.; Winawer, J.
10.1101/2023.02.11.528137 — neuroscience — Posted on 2025-03-12
3527 Micron-resolution fiber mapping in histology independent of sample preparation
Georgiadis, M.; auf der Heiden, F.; Abbasi, H.; Ettema, L.; Nirschl, J.; Moein Taghavi, H.; Wakatsuki, M.; Liu, A.; Ho, W. H. D.; Carlson, M.; Doukas, M.; Koppes, S. A.; Keereweer, S.; Sobel, R. A.; Setsompop, K.; Liao, C.; Amunts, K.; Axer, M.; Zeineh, M. M.; Menzel, M.
10.1101/2024.03.26.586745 — pathology — Posted on 2025-03-12
3534 Stability and characterization of infectious monkeypox virus extracellular virions in vitro2and vivo; implications for transmission, pathogenesis and treatment
Spik, K.; Davis, C. I.; Bixler, S.; Garrison, A. R.; Golden, J. W.; Piper, A. E.; Koehler, J. W.; Williams, J. A.; RICKS, K. M.; Mucker, E. M.
10.1101/2025.03.12.642804 — microbiology — Posted on 2025-03-12
3537 Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer
Chang, A. C.; Balic, M.; Bartholow, T.; Bhargava, R.; Brown, D. D.; Brown, L.; Brufsky, A.; Cao, Y.; Carleton, N.; Clark, A. M.; Cody, M.; Ding, K.; Deible, C.; Elangovan, A.; Foldi, J.; Geisler, D.; Hodgdon, C.; Howard, N.; Li, Z.; Liu, J. B.; Lopez-Nunez, O.; Mary, S. J.; McGinn, O.; Miller, L.; Mori, K.; Pecar, G.; Priedigkeit, N.; Puhalla, S.; Rosenzweig, M. Q.; Roy, P.; Savariau, L.; Walker, S.; Waltermire, H.; Wedn, A. M.; Wells, A.; Yates, M. E.; Xavier, J.; Lee, A. V.; Oesterreich, S.
10.1101/2024.11.06.621982 — cancer biology — Posted on 2025-03-12
3538 Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD
Wei, K.; Xue, F.; Xu, Q.; Yuan, Y.; Zhang, Y.; Qin, G.; Wani, A. H.; Aiello, A. E.; Wildman, D. E.; Uddin, M.; Qu, A.
10.1101/2024.02.06.579228 — bioinformatics — Posted on 2025-03-12
3539 Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing
Malinsky, M.; Talbi, M.; Zhou, C.; Maurer, N. W.; Sacco, S.; Shapiro, B.; Peichel, C. L.; Seehausen, O.; Salzburger, W.; Weber, J. N.; Bolnick, D. I.; Green, R. E.; Durbin, R.
10.1101/2025.03.06.641907 — genetics — Posted on 2025-03-12
3540 What lurks in the dark? - An innovative framework for studying diverse wild insect microbiota
Nowak, K. H.; Hartop, E.; Prus-Frankowska, M.; Buczek, M.; Kolasa, M.; Roslin, T.; Ovaskainen, O. T.; Łukasik, P.
10.1101/2024.08.26.609658 — ecology — Posted on 2025-03-12
3546 Pathological α-Synuclein Perturbs Nuclear Integrity
Millett, M.; Comite, A.; Castosa, E. M.; Heuberger, A.; Wagner, P.; Gallardo, I.; Reinhardt, J.; Chambers, N.; Hall, D.; Miller, E.; Nabert, D.; Balsamo, B.; Prokop, S.; Moehle, M.
10.1101/2025.03.04.641384 — neuroscience — Posted on 2025-03-12
3550 Molecular and biological characterization of a distinct species of Lolavirus infecting different accessions of seashore paspalum, a turfgrass, widely grown in the United States
Bera, S.; Schulden, T. F.; Xu, X.; Abrahamian, P.; Yang, Y.; Paulson, A. L.; Harvey-White, A.; Pradhan, S.; Devos, K.; Devorshak, C.; Foster, J. A.; Adhikari, B. N.
10.1101/2025.03.07.642087 — pathology — Posted on 2025-03-12
3553 Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing
Verstraten, R.; Cetraro, P.; Fitzpatrick, A. H.; Alwie, Y.; Frommeyer, Y. N.; Loliashvili, E.; Stein, S. C.; Haeussler, S.; Ouwendijk, W. J.; Depledge, D. P.
10.1101/2025.03.07.641986 — systems biology — Posted on 2025-03-12
3557 Enteroendocrine Cells Regulate Intestinal Barrier Permeability
Nwako, J. G.; Patel, S. D.; Roach, T. J.; Gupte, S. R.; Williams, S. G.; Riedman, A. M.; McCauley, H. A.
10.1101/2025.03.07.642036 — physiology — Posted on 2025-03-12
3558 BMAL2 controls adipose tissue inflammation and metabolic adaptation during obesity
Philippe, M. A.; Fruchet, B.; Cagninacci, L.; Beaudoin, L.; Gadault, A.; Venteclef, N.; Challet, E.; Lehuen, A.; Rogner, U. C.; Toubal, A.
10.1101/2025.03.11.641984 — pathology — Posted on 2025-03-12
3559 Tumbleweed: an artificial motor protein that walks along a DNA track
Nilsson, P.; Robertson, N. O.; Gustafsson, N.; Davies, R.; Liew, C.; Lyons, A.; Eichhorn, R.; Niman, C.; Blab, G.; Bromley, E.; Whitten, A. E.; Duff, A.; Beech, J.; Jönsson, P.; Böcking, T.; Höcker, B.; Woolfson, D.; Forde, N. R.; Linke, h.; Curmi, P.
10.1101/2025.03.07.641123 — biophysics — Posted on 2025-03-12
3562 Mutations of short tandem repeats explain abundant trait heritability in Arabidopsis
Zhang, Z.-Q.; Jiang, J.; Xu, Y.-C.; Dent, C.; Sureshkumar, S.; Balasubramanian, S.; Guo, Y.
10.1101/2025.03.07.641981 — evolutionary biology — Posted on 2025-03-12
3565 Biodiversity modulates the size-abundance relationship in changing environments
Gjoni, V.; Altermatt, F.; Garnier, A.; Palamara, G. M.; Seymour, M.; Pontarp, M.; Pennekamp, F.
10.1101/2025.03.07.642014 — ecology — Posted on 2025-03-12
3567 Bromodomain proteins as new drug target for an inborn lysosomal defect
Parente, M.; Barthelemy, A.; Tonini, C.; Caputo, S.; Sacchi, A.; Leone, S.; Segatto, M.; Pfrieger, F. W.; Pallottini, V.
10.1101/2023.12.19.572384 — cell biology — Posted on 2025-03-12
3570 Single cell transcriptomic analyses of human heart failure with preserved ejection fraction
Hahn, V. S.; Chaffin, M.; Simonson, B.; Jenkin, S.; Mulligan, A. S.; Bedi, K.; Margulies, K. B.; Klattenhoff, C.; Sharma, K.; Kass, D. A.; Ellinor, P. T.
10.1101/2025.03.06.641949 — bioinformatics — Posted on 2025-03-12
3576 NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer
Ticha, P.; Northey, J. J.; Kersten, K.; Velozo, H. G.; Ironside, A. J.; Zidek, M.; Drain, A.; Lakins, J. N.; Chen, Y.-Y.; Tsai, K. K.; Weaver, V. M.
10.1101/2025.03.10.642060 — cancer biology — Posted on 2025-03-12
3578 DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins
Xu, L.; Jin, S.; Urem, M.; Lee, S.-J.; Lamers, M.; Chen, X.; Wolynes, P.; Wuite, G. J. L.
10.1101/2025.03.07.642097 — biophysics — Posted on 2025-03-11
3582 Foam film vitrification for cryo-EM
Zhang, Y.; Nandy, B.; Sader, K.; Russo, C.; Löwe, J.
10.1101/2025.03.10.642366 — biophysics — Posted on 2025-03-11
3584 Bounding phenotype transition probabilities via conditional complexity
Dingle, K.; Hagolani, P.; Zimm, R.; Umar, M.; O'Sullivan, S.; Louis, A.
10.1101/2024.12.18.629197 — biophysics — Posted on 2025-03-12
3586 Hydrodynamic Radius Determination of Tau and AT8 Phosphorylated Tau Mutants: A Combined Simulation and Experimental Study
Lohberger, C.; Marien, J.; Bridot, C.; Prevost, C.; Allegro, D.; Tatoni, M.; Landrieu, I.; Smet-Nocca, C.; Sacquin-Mora, S.; Barbier, P.
10.1101/2025.02.22.639620 — biophysics — Posted on 2025-03-12
3587 SUMOylation Restricts Adaptive Thermogenesis by Suppressing Beiging Gene Networks
Nothnagel, P. M.; Briand, N.; Wik, J. A.; Strom, Y. E.; Bjoras, M.; Enserink, J. M.; Skalhegg, B. S.; Mathelier, A.; Chymkowitch, P.
10.1101/2025.03.07.642034 — molecular biology — Posted on 2025-03-11
3588 Foam film vitrification for cryo-EM
Zhang, Y.; Nandy, B.; Sader, K.; Russo, C.; Löwe, J.
10.1101/2025.03.10.642366 — biophysics — Posted on 2025-03-12
3592 Chromatin retained MUSHER lncRNA integrates ABA and DOG1 signalling pathways to enhance Arabidopsis seeds dormancy.
Sacharowski, S.; Krzyszton, M.; Brzezniak, L.; Rogowski, K. J.; Montez, M.; Rosol, K.; Wrona, M.; Yatusevich, R.; Manjunath, V. H.; Szewc, L.; Jarmolowski, A.; Swiezewski, S.
10.1101/2025.02.19.639109 — molecular biology — Posted on 2025-03-12
3594 Obesity Increases Atherosclerosis Susceptibility via Inter-tissue miR-30e-SLC7A11 Axis
Wang, C.; She, J.; Qian, X.; Wu, H.; Hao, W.; Liang, X.; Guo, N.; Dai, X.; He, F.; He, S.; Zhang, J.; Lei, Y.; Zhuo, X.; Li, H.; Luo, Y.; Deng, K.; Liu, Y.; Gao, S.; Yuan, X.; Liu, H.; Bai, T.; Xiong, Y.; Shyy, J. Y.-J.; Yuan, Z.-Y.
10.1101/2025.03.06.641950 — molecular biology — Posted on 2025-03-12
3595 Nucleosome Engagement Regulates RORγt Structure and Dynamics
Strutzenberg, T. S.; Mann, M. D.; Li, X.; Shin, H.; Kelsey, J.; Aiyer, S.; Yu, J.; Zhang, Z.; Gray, G.; Shan, Z.; Zhou, B.; Zheng, Y.; Griffin, P. R.; Lyumkis, D.
10.1101/2025.03.10.642251 — biophysics — Posted on 2025-03-12
3596 Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression
Elsaid, S. A.; Meesala, P.; Choi, Y.; Yu, L.; Xiao, Y.; Lazar, M.; Perez-Matute, P.; Alaby Pinheiro Faccioli, L.; Sun, Y.; Rodrigo, F.; Soto-Gutierrez, A.; Pichel, J. M.; List, E. O.; Berryman, D.; Kopchick, J.; Mayer, D.; Tee, S. S.
10.1101/2025.01.01.630846 — molecular biology — Posted on 2025-03-12
3597 Bacterial chromatin remodeling associated with transcription-induced domains at pathogenicity islands
Kortebi, M.; Bourge, M.; Le Bars, R.; van Dijk, E.; Dorman, C. J.; Bury-Mone, S. G.; Boccard, F.; Lioy, V. S.
10.1101/2025.03.11.642640 — microbiology — Posted on 2025-03-11
3598 RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera
Simonich, C. A.; McMahon, T. A.; Ju, X.; Yu, T. C.; Brunette, N.; Stevens-Ayers, T.; Boeckh, M. J.; King, N. P.; Greninger, A. L.; Bloom, J. D.
10.1101/2025.03.11.642476 — microbiology — Posted on 2025-03-11
3599 New insights on malaria parasite adaptation yielded by samples archived for more than 50 years
Amambua-Ngwa, A.; Diop, M. F.; Drakeley, C.; d'Alessandro, U.; Kwiatkowski, D. P.; Conway, D.
10.1101/2025.03.11.642566 — microbiology — Posted on 2025-03-11
3604 Bimodality in pan-cancer proteomics reveals new opportunities for biomarker discovery
Jiang, W.; Bikiel, D.; Zaucha, J.; Wang, J.; Jayabalan, S.; Li, Y.; Sung, M.; Harper, J.; Zhao, J.; Bulusu, K. C.; Zhong, W.
10.1101/2025.03.03.641218 — bioinformatics — Posted on 2025-03-12
3605 Metabolic heterogeneity coupled with a resistance gene generates antibiotic heteroresistance
Choby, J. E.; Hufnagel, D. A.; Ma, M.; Ozturk, T.; Band, V. I.; Kim, M.; Weiss, D.
10.1101/2025.03.11.641639 — microbiology — Posted on 2025-03-11
3607 Comparative mortality of dominant Staphylococcus aureus lineages in human bacteremia and animal infection models
Sanchez-Osuna, M.; Bravo, M.; Canas, M.-A.; Gomez, A.-C.; Gomez-Sanchez, I.; Miro, J. M.; Gibert, I.; Gasch, O.; Garcia-de-la-Maria, C.; Yero, D.; Pich, O. Q.
10.1101/2025.03.11.642576 — microbiology — Posted on 2025-03-11
3608 Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial
Wong, M.; Armstrong, E.; Heirali, A.; Schneeberger, P. H.; Chen, H.; Cochrane, K.; Sherriff, K.; Allen-Vercoe, E.; Siu, L. L.; Spreafico, A.; Coburn, B.
10.1101/2025.03.11.642547 — microbiology — Posted on 2025-03-11
3609 BR-Bodies Facilitate Adaptive Responses and Survival During Copper Stress in Caulobacter crescentus
Passos, C. C.; Tomares, D. T.; Yassine, H.; Schnorr, W. E.; Hunter, H.; Wolfe-Feichter, H. K.; Velier, J.; Dzurik, K. G.; Grillo, J.; Gega, A.; Saxena, S. K.; Schrader, J. M.; Childers, W. S.
10.1101/2025.03.11.642215 — microbiology — Posted on 2025-03-11
3610 A novel crustavirus associated with tail fan necrosis in New Zealand red rock lobsters, Jasus edwardsii
Grimwood, R.; Zamora, L.; Darnley, J.; Delisle, L.; Hutson, K.; Hills, J.; Geoghegan, J. L.
10.1101/2025.03.10.642514 — microbiology — Posted on 2025-03-11
3611 Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen
Stocke, K. S.; Pandey, S. D.; Jin, S.; Perpich, J. D.; Yakoumatos, L.; Kosaki, H.; Wilkey, D. W.; Fitzsimonds, Z. R.; Vashishta, A.; Snider, I.; Sriwastva, M. K.; Li, H.; Jin, J.-Z.; Miller, D. P.; Merchant, M. L.; Bagaitkar, J.; Uriarte, S. M.; Potempa, J.; Lamont, R. J.
10.1101/2025.03.11.642667 — microbiology — Posted on 2025-03-11
3612 Cannabinoid receptor deficiencies drive immune response dynamics in Salmonella infection
Barker, H. A.; Bhimani, S.; Tirado, D.; Lemos, L. N.; Roesch, L. F. W.; Ferraro, M. J.
10.1101/2025.03.10.642352 — microbiology — Posted on 2025-03-11
3614 Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection
Nouwen, L. V.; Zaal, E. A.; Buitendijk, I.; Zwaagstra, M.; Aloise, C.; Van Vliet, A. L. W.; Schipper, J. G.; Van Mil, A.; Berkers, C. R.; van Kuppeveld, F. J. M.
10.1101/2025.03.11.642588 — microbiology — Posted on 2025-03-11
3615 Comparative Transcriptomic Analysis of Embryonic Stem Cells (ESCs) across Mammalian Species
Fang, Y.; Su, Y.; Meisel, R.; Walters, J. R.; Gamble, T.; Randolph, E. C.; Yu, X.; Shi, M.; Li, G.; Zhang, J.; Tian, X.; Tang, Y.; Duan, E.
10.1101/2025.03.11.642582 — genomics — Posted on 2025-03-12
3618 Overcoming variability challenges for Clostridioides difficile via data augmentation techniques
Guerrero-Lopez, A.; Bravo-Anton, L.; Blazquez-Sanchez, M.; Schmidt-Santiago, L.; Sevilla-Salcedo, C.; Rodriguez-Temporal, D.; Rodriguez-Sanchez, B.; Gomez-Verdejo, V.
10.1101/2024.10.29.620907 — microbiology — Posted on 2025-03-12
3619 Systematic Determination of the Impact of Structural Edits on Peptide Accumulation into Mycobacteria
Dash, R.; Liu, Z.; Lepori, I.; Chordia, M.; Ocius, K. L.; Holsinger, K.; Zhang, H.; Kenyon, R.; Im, W.; Siegrist, M. S.; Pires, M.
10.1101/2025.01.17.633618 — microbiology — Posted on 2025-03-12
3620 3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
Vangelisti, S.; Chong, F.; Dietl, T.; Zywitza, V.; Diecke, S.; Enard, W.; Bonev, B.
10.1101/2025.03.11.642620 — genomics — Posted on 2025-03-12
3623 Antibody-Free Immunopeptide Nano-Conjugates for Brain-Targeted Drug Delivery in Glioblastoma Multiforme
Sharma, S.; Lee, D.; Maity, S.; Singh, P.; Chadokiya, J.; Mohaghegh, N.; Hassani, A.; Kim, H.; Gangarade, A.; Ljubimova, J. Y.; Kirane, A. R.; Holler, E.
10.1101/2025.03.07.641755 — immunology — Posted on 2025-03-12
3624 Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci
Lee, D.; Gunamalai, L.; Kannan, J.; Vickery, K.; Yaacov, O.; Onuchic-Whitford, A.; Chakravarti, A.; Kapoor, A.
10.1101/2025.03.11.642686 — genetics — Posted on 2025-03-12
3625 GSK-3 regulates CD4-CD8 cooperation needed to generate super-armed CD8+ cytolytic T cells against tumors
Moes, B.; Janna, J.; Kazanova, A.; LIU, C.; Gao, Y.; Ponnoor, N. A.; Castoun-Puckett, L.; Oroya, A.; Nguyen, H. L.; Cabald, A. L.; Tu, T. H.; Rudd, C. E.
10.1101/2025.03.08.642085 — immunology — Posted on 2025-03-12
3626 Regulation of B cell tolerance and autoimmunity by miR-130b
Herrero-Fernandez, B.; Gonzalez-Molina, M. d. P.; Gamez-Reche, L.; Prieto-Munoz, A. M.; Sanz, J.; Gonzalo, T.; Moreno, A.; Lopez-Molina, M.; Manas, L.; Nemazee, D.; Xiao, C.; Otero-Ortega, L.; Gonzalez-Martin, A.
10.1101/2025.01.22.634242 — immunology — Posted on 2025-03-12
3627 Phenotypic analysis of 11,125 trio exomes in neurodevelopmental disorders
Ganesan, S.; Ruggiero, S. M.; Parthasarathy, S.; Galer, P. D.; Lewis-Smith, D.; Mcsalley, I.; Cohen, S. R.; Lusk, L.; Prentice, A. J.; McKee, J. L.; Pendziwiat, M.; Smith, L.; Weber, Y.; Mefford, H. C.; Poduri, A.; Helbig, I.
10.1101/2025.03.11.642649 — genetics — Posted on 2025-03-12
3628 Prenatal DEHP plastic chemical exposure increases the likelihood of child autism and ADHD symptoms through epigenetic programming
Tanner, S.; Eisner, A.; Novakovic, B.; Holland, L.; Mansell, T.; England-Mason, G.; Merrill, S.; Dewey, D.; OHely, M.; Symeonides, C.; Saffery, R.; Mueller, J.; Tang, M. L.; Sly, P. D.; Vuillermin, P.; the BIS Investigator Group, ; Jung, C.-H.; Park, D.; Ponsonby, A.-L.
10.1101/2025.03.03.641339 — neuroscience — Posted on 2025-03-12
3629 Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation
Sarafinovska, S.; Koester, S. K.; Fang, L. Z.; Thorpe, J. W.; Chaturvedi, S. M.; Ji, J.; Jones, E. F.; Selmanovic, D.; Kornbluth, D. J.; Barrett, M. R.; Rurak, G. M.; Maloney, S. E.; Creed, M. C.; Mitra, R. D.; Dougherty, J. D.
10.1101/2025.03.10.642464 — genetics — Posted on 2025-03-12
3632 Visualization of stochastic expression of clustered protocadherin β isoforms in vivo
Kaneko, R.; Takatsuru, Y.; Abe, M.; Inoue, Y. U.; Morita, A.; Horino, S.; Inoue, T.; Watanabe, M.; Sakimura, K.; Yanagawa, Y.; Yagi, T.
10.1101/2025.03.04.641360 — neuroscience — Posted on 2025-03-12
3633 Fiber Microstructure Quantile (FMQ) Regression: A Novel Statistical Approach for Analyzing White Matter Bundles from Periphery to Core
Lan, Z.; Chen, Y.; Rushmore, J.; Zekelman, L.; Makris, N.; Rathi, Y.; Golby, A. J.; Zhang, F.; O'Donnell, L. J.
10.1101/2024.10.19.619237 — neuroscience — Posted on 2025-03-12
3634 High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains
Kikawa, C.; Loes, A. N.; Huddleston, J.; Figgins, M. D.; Steinberg, P.; Griffiths, T.; Drapeau, E. M.; Peck, H.; Barr, I. G.; Englund, J. A.; Hensley, S. E.; Bedford, T.; Bloom, J. D.
10.1101/2025.03.04.641544 — evolutionary biology — Posted on 2025-03-12
3636 Multimodal brain cell atlas across the adult macaque lifespan
Zhang, X.; Lai, G.; Guo, X.; Ma, W.; Yuan, Y.; Zhang, H.; Fan, P.; Liu, X.; Guo, P.; An, J.; Li, J.; Huang, K.; Zuo, J.; Wu, L.; Shangguan, S.; Yu, F.; Xiang, Y.; Hu, Y.; Huang, Y.; Lin, Y.; He, D.; Pan, M.; Chen, L.; Li, B.; Yang, W.; Yin, P.; Li, S.; Zhang, X.; Yang, T.; Chen, J.; Zhong, Q.; Lv, Y.; Qin, B.; Qing, X.; Deng, Q.; Huang, Y.; Liu, C.; Han, L.; Liu, S.; Qin, D.; Liu, Z.; Zhou, Y.; Qiao, L.; Li, C.; Zhang, Y.; Volpe, G.; Graf, S.; Diks, I. F.; Flotho, M.; Krol, R. P.; Mulder, J.; Hutchins, A. P.; Keller, A.; Maxwell, P. H.; Rubinsztein, D. C.; Liu, X.; Tse, H.-F.; Poo, M.; Wang, B
10.1101/2025.03.11.641786 — neuroscience — Posted on 2025-03-12
3637 Alpha and Beta Oscillations Mediate the Effect of Motivation on Neural Coding of Cognitive Flexibility
Delgado, J. M. C.; Ison, M. J.; Muhle-Karbe, P. S.; Stokes, M. G.; Hall-McMaster, S.; Myers, N. E.
10.1101/2025.03.11.642697 — neuroscience — Posted on 2025-03-12
3638 Cell-free Reconstitution Reveals Synergistic Stabilization of Microtubule Doublets by PACRG and FAP20
Khuntsariya, D.; Batman, U.; Krishnan, A.; Rozbesky, D.; Lemaitre, F.; Janke, C.; Hamel, V.; Guichard, P.; Braun, M.; Lansky, Z.
10.1101/2025.03.12.642377 — cell biology — Posted on 2025-03-12
3640 Identification of a neural basis for energy expenditure in the arcuate hypothalamus
Wang, T.; Han, S.; Wang, Y.; Li, Y.; Zhang, S.; Zhu, F.; Chen, Z.-H.; Xing, Z.; Li, Y. Z.; Wang, J.; Xu, M.; Liu, Q.; Jiang, M.; Xu, X.; Li, X.; Cao, P.; Gong, H.; Wu, Q.-F.
10.1101/2025.03.11.642601 — neuroscience — Posted on 2025-03-12
3644 Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans and Non-Human Primates
Conwell, C.; MacMahon, E.; Jagadeesh, A.; Vinken, K.; Sharma, S.; Prince, J. S.; Alvarez, G. A.; Konkle, T.; Livingstone, M.; Isik, L.
10.1101/2025.03.05.641284 — neuroscience — Posted on 2025-03-12
3645 Adherence to Lifes Essential 8 Enhances Gut Microbiota Diversity and Cognitive Performance
Wadop, Y. N.; Muhammad, J.; Bernal, R.; Satizabal, C. L.; Beiser, A.; Vasan, R. S.; Xavier, R.; Kautz, T.; Seshadri, S.; Himali, J. J.; Fongang, B.
10.1101/2025.03.02.641089 — neuroscience — Posted on 2025-03-12
3646 Noradrenergic efferent subsystems that gate traumatic social learning
Seiriki, K.; Maeda, S.; Kojima, L.; Fujimoto, Y.; Baba, T.; Rokujo, H.; Nitta, T.; Nakazawa, T.; Kasai, A.; Hikida, T.; Hashimoto, H.
10.1101/2025.03.07.641347 — neuroscience — Posted on 2025-03-12
3647 Local modulation of sleep slow waves depends on timing between auditory stimuli
Leach, S.; Fattinger, S.; Krugliakova, E.; Skorucak, J.; Sousouri, G.; Snipes, S.; Schühle, S.; Ferster, M. L.; Da Poian, G.; Karlen, W.; Huber, R.
10.1101/2025.03.05.641406 — neuroscience — Posted on 2025-03-12
3648 Transcriptomic Analysis of CAD Cell Differentiation
Cevallos, C. A.; White, A. L.; Fazio, B. A.; Wendt, L. S.; Feng, J. W.; Posfai, D.; Horton, A. L.; Warrick, J. M.; Quintero-Carmona, O. A.
10.1101/2025.03.09.642086 — neuroscience — Posted on 2025-03-12
3652 Designer antisense circRNAGFP reduces GFP protein abundance in Arabidopsis protoplasts in a sequence-specific manner, independent of RNAi pathways
Hossain, M.; Pfafenroth, C.; Nasfi, S.; Sede, A. R.; Imani, J.; Secic, E.; Galli, M.; Schaefer, P.; Bindereif, A.; Heinlein, M.; Ladera, M.; Kogel, K.-H.
10.1101/2023.11.20.567890 — plant biology — Posted on 2025-03-12
3653 MYB93 regulates responses to environmental sulphur in Arabidopsis and tomato.
Cao, X.; Wilkinson, H. B.; Hutton, B.; McMulkin, N.; Graham, N. S.; Etherington, R.; Oliver, A. G.; Clayton, C. M.; Kaur, H.; Coates, J. C.
10.1101/2025.03.04.641362 — plant biology — Posted on 2025-03-12
3654 Delineating inter- and intra-antibody repertoire evolution with AntibodyForests
van Ginneken, D.; Tromp, V.; Stalder, L.; Cotet, T.-S.; Bakker, S.; Samant, A.; Reddy, S. T.; Yermanos, A.
10.1101/2025.03.11.642619 — bioinformatics — Posted on 2025-03-12
3655 A new corrector rescues F508del-CFTR folding through stabilization of the TMD1-NBD1 linker
van der Sluijs, P.; Papaioannou, O.; Hagos, A.; Saleh, A. M.; Hodges, T.; Balut, C.; Green, M.; Alani, S.; Fan, Y.; Ebine, K.; Schrimpf, M.; Hardee, D.; Li, H.-Q.; Korman, H.; Tade, L.; van Zadelhoff, G.; Singh, A.; Tse, C.; Braakman, I.
10.1101/2025.03.10.640553 — biochemistry — Posted on 2025-03-12
3662 Revisiting face-to-hand area remapping in the human primary somatosensory cortex after a cervical spinal cord injury
Howell, P.; Rabe, F.; Meneghin, C.; Schading-Sassenhausen, S.; Sonar, H. A.; Paik, J.; Freund, P.; Wenderoth, N.; Kikkert, S.
10.1101/2025.03.11.642631 — neuroscience — Posted on 2025-03-12
3663 Talk2Biomodels: AI agent-based open-source LLM initiative for kinetic biological models
Wehling, L.; Singh, G.; Mulyadi, A. W.; Sreenath, R. H.; Hermjakob, H.; Nguyen, T. V. N.; Rueckle, T.; Mosa, M. H.; Cordes, H.; Andreani, T.; Klabunde, T.; Malik Sheriff, R. S.; McCloskey, D.
10.1101/2025.03.11.642548 — systems biology — Posted on 2025-03-12
3664 Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells
Mitra, A.; Cutiongco, M. F.; Burla, R.; Zeng, Y.; Qin, N.; Kong, M.; Vinod, B.; Nai, M. H.; Hübner, B.; Ludwig, A.; Lim, C. T.; Shivashankar, G.; Saggio, I.; ZHAO, W.
10.1101/2025.03.06.641794 — bioengineering — Posted on 2025-03-11
3665 Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction
Wang, W.; Han, Z.; Aafreen, S.; Zivko, C.; Gololobova, O.; Wei, Z.; Cotin, G.; Felder-Flesch, D.; Mahairaki, V.; Witwer, K. W.; Bulte, J. W. M.; Weiss, R. G.; Liu, G.
10.1101/2025.03.02.641040 — bioengineering — Posted on 2025-03-11
3666 Chromatin remodeling integrates vertebrate body axis elongation and cell fate determination
Li, S. K.; viet, N. t.; Bu, w.; Fan, H.; Pan, D.; Wang, Z.; Chen, D.; Zhang, D.; Jin, Y.; Fan, Y.; Du, J.
10.1101/2025.03.11.642544 — developmental biology — Posted on 2025-03-12
3667 The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice.
Kageyama, A.; Ogonuki, N.; Wakai, T.; Namiki, T.; Kawata, Y.; Ozawa, M.; Yamada, Y.; Fukada, T.; Ogura, A.; Fissore, R. A.; Kashiwazaki, N.; Ito, J.
10.1101/2024.09.11.612381 — developmental biology — Posted on 2025-03-12
3670 Light-induced reversible assembly and actuation in ultrafast Ca2+-driven chemomechanical protein networks
Lei, X.; Floyd, C.; Ferrer, L. C.; Chakrabortty, T.; Chandrasekharan, N.; Dinner, A.; Coyle, S. M.; Honts, J.; Bhamla, S.
10.1101/2025.03.03.641304 — bioengineering — Posted on 2025-03-12
3673 Low-Background Cancer Imaging With a Bioorthogonal Fluorescence Probe and Engineered Reporter Enzyme Bearing a Targeting Moiety
Wang, Z.; Kojima, R.; Kiji, R.; Fujita, K.; Tachibana, R.; Uchiyama, T.; Minagawa, Y.; Mizuno, T.; Igarashi, K.; Noji, H.; Kamiya, M.; Urano, Y.
10.1101/2025.03.04.641560 — bioengineering — Posted on 2025-03-12
3674 Dual PAX3/7 transcriptional activities spatially encode spinal cell fates through distinct gene networks
Rondon, R.; Hezez, T.; Richard-Albert, J.; Drayton-Libotte, B.; Gonzalez-Curto, G.; Relaix, F.; Dugast, C.; Gilardi-Hebenstreit, P.; Ribes, V.
10.1101/2025.03.11.642668 — developmental biology — Posted on 2025-03-12
3675 Isoform-specific patterns of phosphorylation on axonemal dynein heavy chains
Sakato-Antoku, M.; Patel-King, R. S.; Inaba, K.; Balsbaugh, J. L.; King, S. M. M.
10.1101/2025.03.10.642390 — cell biology — Posted on 2025-03-12
3676 Brain neuromarkers predict self- and other-related mentalizing across adult, clinical, and developmental samples
Acil, D.; Andrews-Hanna, J. R.; Lopez-Sola, M.; van Buuren, M.; Krabbendam, L.; Zhang, L.; van der Meer, L.; Fuentes-Claramonte, P.; Pomarol-Clotet, E.; Salvador, R.; Debbane, M.; Vrticka, P.; Vuilleumier, P.; Sbarra, D. A.; Coppola, A. M.; White, L. O.; Wager, T. D.; Koban, L.
10.1101/2025.03.10.642438 — neuroscience — Posted on 2025-03-12
3677 Redefining the Role of the EryM Acetyltransferase in Natural Product Biosynthetic Pathways
Li, Y.; Liu, X.; Harris, N. R.; Roberts, J. R.; Valdivia, E. M.; Ji, X.; Smith, J. L.
10.1101/2025.03.07.642089 — biochemistry — Posted on 2025-03-11
3678 Deciphering Ibogaines Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses
Hwu, C.; Havel, V.; Westergaard, X.; Mendieta, A. M.; Serrano, I. C.; Hwu, J.; Walther, D.; Lankri, D.; Selinger, T. L.; He, K.; Liu, R.; Shern, T. P.; Sun, S.; Ma, B.; Gonzalez, B.; Goodman, H. J.; Sonders, M. S.; Baumann, M. H.; Carrera, I.; Sulzer, D.; Sames, D.
10.1101/2025.03.04.641351 — neuroscience — Posted on 2025-03-12
3679 A new corrector rescues F508del-CFTR folding through stabilization of the TMD1-NBD1 linker
van der Sluijs, P.; Papaioannou, O.; Hagos, A.; Saleh, A. M.; Hodges, T.; Balut, C.; Green, M.; Alani, S.; Fan, Y.; Ebine, K.; Schrimpf, M.; Hardee, D.; Li, H.-Q.; Korman, H.; Tade, L.; van Zadelhoff, G.; Singh, A.; Tse, C.; Braakman, I.
10.1101/2025.03.10.640553 — biochemistry — Posted on 2025-03-11
3681 A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis
de Carvalho, E.; Amin, A.; LiIttle, R.; Silva, K. F.; Gaspar, C.; Badenes, M.; Burbridge, E.; Paixao, T.; Amorim, M. J.; Faisca, P.; Fischer, R.; Vendrell, I.; O'Brien, D. P.; Strisovsky, K.; Christianson, J. C.; Domingos, P.; Adrain, C.
10.1101/2025.03.10.642408 — biochemistry — Posted on 2025-03-11
3682 Isoform-specific patterns of phosphorylation on axonemal dynein heavy chains
Sakato-Antoku, M.; Patel-King, R. S.; Inaba, K.; Balsbaugh, J. L.; King, S. M. M.
10.1101/2025.03.10.642390 — cell biology — Posted on 2025-03-11
3683 A sensory map of the gastrointestinal tract
Hasnah, R.; Makhlouf, M.; Zambon, M.; Arietti, M.; Altun, Y. G. K.; Scialdone, A.; Saraiva, L. R.; Kaelberer, M. M.
10.1101/2025.03.07.641228 — neuroscience — Posted on 2025-03-11
3684 Transcriptomic Analysis of CAD Cell Differentiation
Cevallos, C. A.; White, A. L.; Fazio, B. A.; Wendt, L. S.; Feng, J. W.; Posfai, D.; Horton, A. L.; Warrick, J. M.; Quintero-Carmona, O. A.
10.1101/2025.03.09.642086 — neuroscience — Posted on 2025-03-11
3688 Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read sequencing
Trinh, A.; Akhtar, N.; Bonsu, K.; Laszik, N.; Mendelevich, A.; Wen, T.; Morival, J. L. P.; Diune, K. E.; Frazeur, M.; Vega, J. E.; Gimelbrant, A.; Read, E. L.; Downing, T. L.
10.1101/2025.03.03.641287 — genomics — Posted on 2025-03-11
3689 Royal Jelly Derived Extracellular Vesicles Modulate Microglial Nanomechanics and Inflammatory Responses
Zavala, G.; Berrios, P.; Sandoval, F.; Bravo, G.; Barrera, N. P.; Alarcon-Moyano, J.; Diaz-Calderon, P.; Aguayo, S.; Schuh, C. M. A. P.
10.1101/2025.03.03.641064 — neuroscience — Posted on 2025-03-11
3690 Regulation of lipid dysmetabolism and neuroinflammation linked with Alzheimer's disease through modulation of Dgat2
Yadav, A.; Ouyang, O.; Barkley, M.; Watson, J.; Madamanchi, K.; Kramer, J.; Zhang, J.; Melkani, G. C.
10.1101/2025.02.18.638929 — physiology — Posted on 2025-03-11
3691 The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune replication processivity and fidelity
O'Neal, L. G.; Drucker, M. N.; Lai, N. K.; Clemente, A. F.; Campbell, A. P.; Way, L. E.; Hong, S.; Holmes, E. E.; Rancic, S. J.; Sawyer, N.; Wang, X.; Thrall, E. S.
10.1101/2025.03.10.642433 — biochemistry — Posted on 2025-03-11
3693 Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome
Xia, L.; Tu, K.; Wang, H.; Liu, X.; Liu, Y.; Zhang, Q.; Feng, Z.; Yu, C.; Li, M.; Huang, Y.; Wang, J.; Wei, R.; Zeng, T.; Pi, X.; Ling, C.; Zhang, Q.; Qiao, Y.; Hou, S.; Zhang, Z.; Wei, A.; Liao, H.; Guo, W.; Liu, J.; Wu, Z.; Wang, Z.; Li, A.; Li, W.; Xie, D.
10.1101/2025.02.19.638966 — genomics — Posted on 2025-03-11
3694 Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinsons disease
Ranxhi, B.; Bangash, Z. R.; Chbihi, Z. M.; Qadri, Z.; Islam, N. N.; Todi, S. V.; LeWitt, P. A.; Tsou, W.-L.
10.1101/2025.03.06.641237 — neuroscience — Posted on 2025-03-11
3695 Predicting and Shaping Human-Machine Interactions in Closed-loop, Co-adaptive Neural Interfaces
Madduri, M. M.; Yamagami, M.; Li, S. J.; Burckhardt, S.; Burden, S. A.; Orsborn, A. L.
10.1101/2024.05.23.595598 — neuroscience — Posted on 2025-03-11
3696 The relationship between cortisol, grid-like representations and path integration
Akan, O.; Chandreswaran, V.; Bierbrauer, A.; Soldan, H.; Axmacher, N.; Wolf, O. T.; Merz, C. J.
10.1101/2025.03.10.642344 — neuroscience — Posted on 2025-03-11
3706 The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2
Morgan, A. L.; Vu, M. N.; Zhou, Y.; Lokugamage, K. G.; Meyers, W.; Alvarado, R. E.; Ahearn, Y. P.; Estes, L. K.; Plante, J. A.; Johnson, B. A.; Suthar, M.; Walker, D. H.; Plante, K. S.; Menachery, V. D.
10.1101/2025.03.10.642264 — microbiology — Posted on 2025-03-11
3707 MUUMI: an R package for statistical and network-based meta-analysis for MUlti-omics data Integration
Inkala, S.; Fratello, M.; del Giudice, G.; Migliaccio, G.; Serra, A.; Greco, D.; Federico, A.
10.1101/2025.03.10.642416 — bioinformatics — Posted on 2025-03-11
3710 Cell-cycle dependent inhibition of BRCA1 signaling by the lysine methyltransferase SET8
PEREZ, Y.; ALHOURANI, F.; PATOUILLARD, J.; Ribeyre, C.; Larroque, M.; BALDIN, V.; Lleres, D.; GRIMAUD, C.; JULIEN, E.
10.1101/2023.11.22.567520 — molecular biology — Posted on 2025-03-11
3711 Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins
Proellochs, N. I.; Andolina, C.; Ramjith, J.; Stoter, R.; van Gemert, G.-J.; Graumans, W.; Campino, S.; Vanheer, L. N.; Okitwi, M.; Tumwebaze, P. K.; Conrad, M. D.; Clark, T. G.; Fidock, D. A.; Menard, D.; Mok, S.; Bousema, T.
10.1101/2024.12.23.630038 — microbiology — Posted on 2025-03-11
3712 Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo
Verwimp, S.; Wagoner, J.; Arenas, E. G.; De Coninck, L.; Abdelnabi, R.; Hyde, J. L.; Schiffer, J.; White, J. M. M.; Matthijnssens, J.; Neyts, J.; Polyak, S. J.; Delang, L.
10.1101/2025.01.24.633564 — microbiology — Posted on 2025-03-11
3715 Molecular exploration of host-pathogen interactions in severe Pseudomonas aeruginosa infection through a multi-level data integration approach
Messina, F.; Rotondo, C.; Ladeira, L.; Crosetti, S.; Properzi, M.; Dimartino, V.; Riccitelli, B.; Staumont, B.; Chillemi, G.; Geris, L.; Bocci, M. G.; Fontana, C.
10.1101/2024.10.17.618881 — systems biology — Posted on 2025-03-11
3717 Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition
Arabanian, L. S.; Adamsson, J.; Unger, A.; Di Lucrezia, R.; Bergbrede, T.; Ashouri, A.; Larsson, E.; Nussbaumer, P.; Klebl, B. M.; Palmqvist, L.; Gustafsson, C. M.
10.1101/2022.09.23.509145 — cancer biology — Posted on 2025-03-11
3719 Comparative analysis of STP6 and STP10 unravels molecular selectivity in Sugar Transport Proteins
Andersen, C. G.; Bavnhoj, L.; Brag, S.; Chrenkov, A.; Driller, J. H.; Pedersen, B. P.; Bohush, A.
10.1101/2024.07.19.604285 — biochemistry — Posted on 2025-03-11
3720 DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation
Yonezawa, T.; Rutter, J.; Ramabadran, R.; Sundaramurthy, V.; Datar, G.; Slabicki, M.; Goodell, M. A.
10.1101/2025.03.05.641683 — biochemistry — Posted on 2025-03-11
3722 A general framework for cycles in ecology
Calleja Solanas, V.; Moura, R. O.; Langa, J. A.; Portillo Fernandez, J. R.; Soler-Toscano, F.; Godoy, O.
10.1101/2025.01.13.632680 — ecology — Posted on 2025-03-11
3723 Decoding human placental cellular and molecular responses to maternal obesity and fetal growth
Jiang, H.; Derisoud, E.; Parreira, D.; Taebnia, N.; Jannig, P. R.; Shafagh, R. Z.; Zhao, A.; Li, C.; Ortiz, M.; Maliqueo, M. A.; Stener-Victorin, E.; Lauschke, V. M.; Deng, Q.
10.1101/2025.01.27.634981 — developmental biology — Posted on 2025-03-11
3724 CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation.
Tajmul, M.; Bhatt, D. N.; Ruje, L.; Price, E.; Ji, Y.; Loukinov, D.; Teif, V. B.; Lobanenkov, V. V.; Pugacheva, E. M.
10.1101/2024.09.25.614770 — cell biology — Posted on 2025-03-11
3728 Facial gestures are enacted via a cortical hierarchy of dynamic and stable codes
Ianni, G. R.; Vazquez, Y.; Rouse, A. G.; Schieber, M.; Prut, Y.; Freiwald, W.
10.1101/2025.03.03.641159 — neuroscience — Posted on 2025-03-11
3730 The FIP 1.0 Data Set: Highly Resolved Annotated Image Time Series of 4,000 Wheat Plots Grown in Six Years
Roth, L.; Boss, M.; Kirchgessner, N.; Aasen, H.; Aguirre-Cuellar, B. P.; Akiina, P. P. A.; Anderegg, J.; Gajardo Castillo, J.; Chen, X.; Corrado, S.; Cybulski, K.; Keller, B.; Kortstee, S. G.; Kronenberg, L.; Liebisch, F.; Nousi, P.; Oppliger, C.; Perich, G.; Pfeifer, J.; Yu, K.; Storni, N.; Tschurr, F.; Volpi, M.; Treier, S.; Zellweger, H.; Zumsteg, O.; Hund, A.; Walter, A.
10.1101/2024.10.04.616624 — plant biology — Posted on 2025-03-11
3732 AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network
Fadini, A.; Li, M.; McCoy, A. J.; Terwilliger, T. C.; Read, R. J.; Hekstra, D. R.; AlQuraishi, M.
10.1101/2025.02.18.638828 — biophysics — Posted on 2025-03-11
3734 Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis
Jaquish, A.; Phung, E.; Gong, X.; Baldominos, P.; Galvan-Pena, S.; Bursulaya, I.; Magill, I.; Marina, E.; ImmgenT consortium, ; Bertrand, K.; Chambers, C.; Munoz-Rojas, A. R.; Agudo, J.; Mathis, D.; Benoist, C.; Ramanan, D.
10.1101/2024.07.09.602739 — immunology — Posted on 2025-03-11
3735 Criterion placement threatens the construct validity of neural measures of consciousness
Fahrenfort, J. J.; Johnson, P. A.; Kloosterman, N. A.; Stein, T.; van Gaal, S.
10.1101/2024.02.22.581517 — neuroscience — Posted on 2025-03-11
3737 The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
Predeina, O.; Atkinson, M.; Wissett, O.; Ali, M.; Visentin, C.; Ricagno, S.; Keeble, A. H.; Howarth, M. R.; Sormanni, P.
10.1101/2025.03.06.641810 — biophysics — Posted on 2025-03-11
3738 Fast volumetric fluorescence lifetime imaging of multicellular systems using single-objective light-sheet microscopy
Dunsing-Eichenauer, V.; Hummert, J.; Chardes, C.; Schönau, T.; Guignard, L.; Galland, R.; Grenci, G.; Tillmann, M.; Koberling, F.; Nock, C.; Sibarita, J.-B.; Viasnoff, V.; Antolovic, I. M.; Erdmann, R.; Lenne, P.-F.
10.1101/2024.03.24.586451 — biophysics — Posted on 2025-03-11
3741 The relationship between cortisol, grid-like representations and path integration
Akan, O.; Chandreswaran, V.; Bierbrauer, A.; Soldan, H.; Axmacher, N.; Wolf, O. T.; Merz, C. J.
10.1101/2025.03.10.642344 — neuroscience — Posted on 2025-03-11
3744 Enhanced Detection of Circular Permutations in Protein Databases
Ding, D. Z.; Li, J. Z.; Zhou, T. Z.; Wang, Y. Z.; Huang, B.; Hu, Y.
10.1101/2024.08.28.610105 — bioinformatics — Posted on 2025-03-11
3745 Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissues
Yarbrough, D.; Chen, R.; Shoemaker, J.; Yu, E.; Ataam, J. A.; Amelung, C.; Karakikes, I.; Gerecht, S.
10.1101/2025.03.06.641764 — bioengineering — Posted on 2025-03-11
3747 Automated Discovery of Therapeutic Biomaterial for Renally Impaired Hyperuricemia Patients by Natural Language Processing and Machine Learning
Zeng, X.; Qiu, J.; Zhao, X.; Liu, K.; Zhao, L.; An, J.; Xiang, L.; Liu, T.; Wang, Z.; Xie, W.; Wang, M.; Luo, J.; Zhang, S.
10.1101/2025.03.05.641578 — biochemistry — Posted on 2025-03-11
3749 Unusual Ecofunctional Traits of Endozoicomonas: A Pan-Genomic Perspective
Lim, S. L.; Chin, C.-H.; Chiou, Y.-J.; Hsu, M.-T.; Chiang, P.-W.; Chen, H.-J.; Tu, Y.-C.; Tang, S.-L.
10.1101/2025.03.06.641946 — ecology — Posted on 2025-03-11
3752 Frequency-Specific Resting-State MEG Network Characteristics of Tinnitus Patients Revealed by Graph Learning
Sadeghi Shabestari, P.; Behjat, H. H.; Van De Ville, D.; Cederroth, C. R.; Edvall, N. K.; Naas, A.; Kleinjung, T.; Neff, P.
10.1101/2025.03.10.642147 — neuroscience — Posted on 2025-03-11
3754 The geometry of the neural state space of decisions
Monsalve-Mercado, M. M.; Stine, G. M.; Shadlen, M. N.; Miller, K. D.
10.1101/2025.01.24.634806 — neuroscience — Posted on 2025-03-11
3756 Biological volume EM with focused Ga ion beam depends on formation of radiation-resistant Ga-rich layer at block face
Yang, Z.; Kim, J.; Baenen, C. M.; Fulton, S. J.; Zhang, G.; Chen, X.; Aronova, M. A.; Leapman, R. D.
10.1101/2024.09.16.613321 — biophysics — Posted on 2025-03-11
3757 Biomimetic hydrogel platform reveals active force transduction from retinal pigment epithelium to photoreceptors
Korpela, S.; Kauppila, M.; Karema-Jokinen, V.; Sukki, L.; Kallio, P.; Skottman, H.; Nymark, S.; Ihalainen, T. O.
10.1101/2025.01.09.632113 — biophysics — Posted on 2025-03-11
3760 A stress-responsive p38 signaling axis in choanoflagellates
Rutaganira, F. U.; Coyle, M. C.; Nguyen, M. H. T.; Hernandez, I.; Scopton, A. P.; Dar, A.; King, N.
10.1101/2022.08.26.505350 — biochemistry — Posted on 2025-03-11
3761 TSHR-targeting nucleic acid aptamer treats Graves' ophthalmopathy via novel allosteric inhibition
Zhang, Y.; Wu, E.; Liu, W.; Zeng, L.; Ling, N.; Wang, H.; Li, Z.; Yao, S.; Pan, T.; Li, X.; Huang, Y.; Li, X.; Tu, Y.; Yan, W.; Wu, J.; Ye, M.; Wu, W.
10.1101/2025.03.07.641992 — biochemistry — Posted on 2025-03-11
3765 Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition
Vasudev, A.; Moore, C. R.; Calindi, A.; Kang, S. W.; Helm, B. R.; Srinivasan, J.; Shah, S.; Zong, R.; Singarapu, N.; Casey, S.; Macintyre, A. N.; Lau, K. S.; Hale, L. P.; Liu, Q.; Manley, N. R.; Ehrlich, L. I. R.; Richie, E. R.
10.1101/2025.03.04.641047 — immunology — Posted on 2025-03-11
3772 Crossover designation recruits condensin to reorganize the meiotic chromosome axis
Leon, V. A.; Markowitz, T. E.; Hong, S.; Raghavan, A. R.; Heldrich, J.; Kim, K. P.; Hochwagen, A.
10.1101/2020.07.16.207068 — genomics — Posted on 2025-03-11
3773 FAIRTraits: an environmentally, methodologically and semantically enriched database of plant traits from Mediterranean populations of 240 species
Garnier, E.; Delalandre, L.; Segrestin, J.; Barkaoui, K.; Kazakou, E.; Navas, M.-L.; Vile, D.; Violle, C.; Bellmann, A.; Bernard-Verdier, M.; Birouste, M.; Blanchard, A.; Bumb, I.; Cruz, P.; Debain, S.; Fayolle, A.; Fortunel, C.; Grigulis, K.; Laurent, G.; Lavorel, S.; Lloret, F.; Perez-Ramos, I.; Prieto, I.; Richarte, J.; Roumet, C.
10.1101/2025.03.06.641916 — ecology — Posted on 2025-03-11
3774 Intraspecies warfare restricts strain coexistence in human skin microbiomes
Mancuso, C. P.; Baker, J.; Qu, E.; Tripp, A. D.; Balogun, I. O.; Lieberman, T.
10.1101/2024.05.07.592803 — microbiology — Posted on 2025-03-11
3776 Tree-based quantification infers proteoform regulation in bottom-up proteomics data
Ammar, C.; Thielert, M.; Weiss, C. A. M.; Rodriguez, E. H.; Strauss, M. T.; Rosenberger, F. A.; Zeng, W.-F.; Mann, M.
10.1101/2025.03.06.641844 — bioinformatics — Posted on 2025-03-11
3777 Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes
Koller, M. S.; Himmelbauer, C.; Fink, S.; Ravichandran, M. C.; Campbell, C.
10.1101/2025.03.05.641640 — genetics — Posted on 2025-03-11
3779 Targeting Enhanced Digestibility: Prioritizing Low Pith Lignification to Complement low p-Coumaric Acid content as environmental stress intensity increase
Main, O.; Lopez-Malvar, A.; Meunier, F.; Guillaume, S.; Jacquemot, M.-P.; Lopez-Marnet, P.-L.; Barotin, C.; Marmagne, A.; Cezard, L.; Fargier, S.; Rey, S.; Larsonneau, P.; Mangel, N.; Uijttewaal, A.; Reymond, M.; Coursol, S.; Mechin, V.
10.1101/2024.04.12.589230 — plant biology — Posted on 2025-03-11
3780 Direct cerebellar control over motor production in a species with extreme cerebellar enlargement
Pedraja, F.; Genecin, M.; Noone, D.; Biderman, D.; Cho, P.; Ehrlich, D. E.; Sawtell, N. B.
10.1101/2025.03.10.642493 — neuroscience — Posted on 2025-03-11
3783 Rho2 regulates granulocyte-triggered stress adaptation and cell wall remodeling in Aspergillus fumigatus
Ruf, D.; Striegler, K.; Brazil, S.; Elsaman, H.; Singh, K.; Lepas, M.; Fernando, L. D.; Brantl, V.; Hess, P.; Dichtl, K.; Aimanianda, V.; Wang, T.; Wagener, J.
10.1101/2025.03.10.642427 — microbiology — Posted on 2025-03-11
3785 The intrinsic cortical geometry of reading
Benn, R. A.; Scholz, R.; Wei, W.; Alberti, F.; Shevchenko, V.; Klatzmann, U.; Holmes, A.; Chiou, R.; Pallavicini, C.; Leech, R.; Smallwood, J.; Jefferies, E.; Bazin, P.-L.; Margulies, D. S.
10.1101/2025.03.10.641861 — neuroscience — Posted on 2025-03-11
3787 Synaptic Gpr85 influences cerebellar granule cells electrical properties and light-induced behavior.
Darche-Gabinaud, R.; Kaafarani, A.; Chazalon, M.; Suain, V.; Hendrickx, E.; Conrard, L.; Lefort, A.; Libert, F.; Demirler, M. C.; Schiffmann, S.; Perez-Morga, D.; Wittamer, V.; Parmentier, M.; PIRSON, I.
10.1101/2025.03.10.642364 — neuroscience — Posted on 2025-03-11
3788 TAC-C uncovers open chromatin interaction in crops and SPL-mediated photosynthesis regulation
Kang, J.; Zhang, Z.; Lin, X.; Liu, F.; Song, Y.; Zhao, P.; Lin, Y.; Luo, X.; Li, X.; Li, Y.; Wang, W.; Liu, C.; Xu, S.; Liu, X.; Xiao, J.
10.1101/2025.02.10.637364 — plant biology — Posted on 2025-03-11
3790 APC loss promotes intestinal transformation through induction of bistable stem cell states
Lengner, C. J.; Li, N.; Myers, R. L.; Zhu, Q.; Tian, Y.; Durning, K. D.; Wang, X.; Leu, N. A.; Rhoades, J. H.; Bankler-Jukes, D. M.; Monaghan, K. E.; Adams-Tzivelekidis, S.; Pomp, O.; Pellon-Cardenas, O.; Blanco, A.; Verzi, M.; Klein, P. S.
10.1101/2025.03.06.641686 — cancer biology — Posted on 2025-03-11
3791 On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC
Madapally, H. V.; Hussein, A. K.; Eriksen, M. W.; Pedersen, B. P.; Khandelia, H.; Stokes, D.
10.1101/2025.03.04.641403 — biophysics — Posted on 2025-03-11
3792 Helical foldamers as selective G-quadruplex ligands
Koenig, A.; Laffile, V.; Thore, S.; Mackereth, C. D.; Yatsunyk, L.; Ferrand, Y.; Largy, E.; Gabelica, V.
10.1101/2025.02.25.640101 — biophysics — Posted on 2025-03-11
3795 Supervised Deep Learning for Efficient Cryo-EM Image Alignment in Drug Discovery with cryoPARES
Sanchez-Garcia, R.; Berndt, A.; Apelbaum, A.; Reeks, J.; Williams, P. A.; Poelking, C.; Deane, C.; Saur, M.
10.1101/2025.03.04.641536 — bioinformatics — Posted on 2025-03-11
3797 A multi-modal whole-slide image processing pipeline for quantitative mapping of tissue architecture, histopathology, and tissue microenvironment
Chen, M.; Ma, H.; Sun, X.; Schwartz, M.; Brand, R. E.; Xu, J.; Gotsis, D. S.; Nguyen, P.; Moore, B. A.; Snyder, L.; Brand, R. M.; Liu, Y.
10.1101/2025.03.05.641761 — bioinformatics — Posted on 2025-03-11
3800 Distinct Membrane Binding Properties of the Two Non-visual Arrestins
Killeen, T. D.; Tepper, K.; Miller, K. W.; Aydin, Y.; Zhuo, Y.; Zhao, S.; Conley, J. M.; Tat, R.; Klug, C.; Marchese, A.; Raicu, V.; Chen, Q.
10.1101/2025.03.06.641943 — biochemistry — Posted on 2025-03-11
3801 Using Aptamers for Protein Scale-up
Callegaro, A.; Peng, X.; Morsch, F.; Code, C.
10.1101/2025.03.04.641353 — biochemistry — Posted on 2025-03-11
3802 DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation
Yonezawa, T.; Rutter, J.; Ramabadran, R.; Sundaramurthy, V.; Datar, G.; Slabicki, M.; Goodell, M. A.
10.1101/2025.03.05.641683 — biochemistry — Posted on 2025-03-11
3805 Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice
Noh, M.; Che, X.; Jin, X.; Lee, D.-K.; Kim, H.-J.; Park, D. R.; Lee, S. Y.; Lee, H.; Gardella, T. J.; Choi, J.-Y.; Lee, S.
10.1101/2024.03.13.584815 — genomics — Posted on 2025-03-11
3807 Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue
Cheng, Y.; Dang, S.; Zhang, Y.; Chen, Y.; Yu, R.; Liu, M.; Jin, S.; Han, A.; Katz, S.; Wang, S.
10.1101/2025.03.06.641951 — genetics — Posted on 2025-03-11
3812 Overflooding Ratios in the Sterile Insect Technique: Toward Sustainable Management of Bagrada hilaris
Mainardi, C. E.; Peccerillo, C.; Paolini, A.; Sforza, R. F. H.; Cemmi, A.; Di Sarcina, I.; Marini, F.; Cristofaro, M.
10.1101/2025.03.05.641589 — ecology — Posted on 2025-03-11
3813 Assisted gene flow yields Acropora palmata corals with robust physiological performance under warmer water temperatures in a land-based nursery
Muller, E. M.; Petrik, C.; Conn, T.; Osborne, C.; Villoch, M.; Clark, A.; Koch, H.; O'Neil, K.; Engelsma, C.; Baums, I.
10.1101/2025.03.03.641242 — ecology — Posted on 2025-03-11
3815 Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis
Bideau, L.; Baduel, L.; Krasovec, G.; Dalle, C.; Lamer, O.; Nicolas, M.; Couetoux, A.; Blugeon, C.; Pare, L.; Vervoort, M.; Kerner, P.; Gazave, E.
10.1101/2025.03.09.642222 — developmental biology — Posted on 2025-03-11
3817 A bioinformatic workflow to facilitate the study of less-understood proteins: the case of SH2D2A
Gilmour, B. C.; Chan, H.; Singh, S.; Nyman, T. A.; Borowicz, P.; Phuyal, S.; Spurkland, A.
10.1101/2025.02.11.637442 — molecular biology — Posted on 2025-03-11
3818 Cap-adjacent 2'-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1
Clemens, E.; Brivio, S.; Al-Khafaji, M.; Eijlers, P.; Kurukulasuriya, M.; MacLeod, D.; Haussmann, I.; Wenzel, M.; Mueller, B.; Soller, M.; Pettitt, J.
10.1101/2025.03.10.638824 — molecular biology — Posted on 2025-03-11
3821 Novel Pan-ALDH Inhibitor KS100 Effectively Targets ALDH+/CD138- Stem-like Cells to Overcome Relapse in Multiple Myeloma
Chitren, R.; Gowda, K.; Robertson, G. P.; Amin, S. G.; Jonnalaagadda, S.; Budak-Alpdogan, T.; Pandey, M. K.
10.1101/2025.03.06.641909 — molecular biology — Posted on 2025-03-11
3822 Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome
Zheng, N.; Wang, D.; Xing, G.; Gao, Y.; Li, S.; Liu, J.; Kang, J.; Sha, S.; Cheng, L.; Fan, S.; Yu, J.; Yan, Q.; Jiang, C.
10.1101/2025.03.10.642414 — microbiology — Posted on 2025-03-11
3824 Preliminary genomic data on five Orientia tsutsugamushi strains isolated in Vellore, India
Kumaraswamy, J.; Kirubananthan, A.; Gunasekaran, K.; Abhilash, K. P. P.; Prakash, J. A. J.
10.1101/2025.03.07.642006 — microbiology — Posted on 2025-03-11
3825 Sulfide is a keystone metabolite for gut homeostasis and immunity
Band, V. I.; Gribonika, I.; Stacy, A.; Bouladoux, N.; Mistry, S.; Burns, A.; Perez-Chaparro, P. J.; Chau, J.; Enamorado, M.; Nagai, M.; Bhushan, V.; Golec, D. P.; Schwartzberg, P. L.; Hourigan, S. K.; Nita-Lazar, A.; Belkaid, Y.
10.1101/2025.03.06.641928 — immunology — Posted on 2025-03-11
3826 Effect of external cues on clock-driven protection from Influenza A infection
Paul, O.; Brook, T. G.; Assi, L.; Shetty, A.; Forrest, K. M.; Cameron, A.; Sehgal, A.; Grant, G.; Sengupta, S.
10.1101/2025.03.03.641279 — immunology — Posted on 2025-03-11
3828 Decoding movie content from neuronal population activity in the human medial temporal lobe
Gerken, F.; Darcher, A.; Goncalves, P. J.; Rapp, R.; Elezi, I.; Niediek, J.; Kehl, M. S.; Reber, T. P.; Liebe, S.; Macke, J. H.; Mormann, F.; Leal-Taixe, L.
10.1101/2024.06.13.598791 — neuroscience — Posted on 2025-03-11
3833 Statistical learning dynamically shapes auditory perception
Luthra, S.; Luor, A.; Tierney, A. T.; Dick, F.; Holt, L. L.
10.1101/2024.09.09.612146 — neuroscience — Posted on 2025-03-11
3834 Brain-wide topographic coordination of traveling spiral waves
Ye, Z.; Ladd, A.; MacKenzie, N.; Kolich, L.; Li, A.; Birman, D.; Bull, M. S.; Daigle, T. L.; Tasic, B.; Zeng, H.; Steinmetz, N. A.
10.1101/2023.12.07.570517 — neuroscience — Posted on 2025-03-11
3835 Sky islands of Southwest China. II: Unraveling hidden species diversity of talpid moles using phylogenomics and skull-based deep learning
He, K.; LI, A.; Martinez, Q.; Wang, X.; Chen, Z.; He, S.; Xie, S.; Zeng, Z.; Wang, K.; Ye, Z.; Ruan, H.; Liu, S.; Lu, Q.; Zheng, X.; Luo, J.; Song, W.; Schwermann, A.; Yu, H.; Yu, W.; Springer, M.; Liu, S.; Li, S.; Tu, F.; Cao, Z.; Campbell, K. L.
10.1101/2025.03.06.641773 — zoology — Posted on 2025-03-11
3836 Context-dependent effects of mutations on complex splicing decisions
Li, C.; Unic, S.; Kuban, M.; Brueggemann, M.; Koenig, J.; Zarnack, K.; Legewie, S.
10.1101/2025.03.06.641829 — systems biology — Posted on 2025-03-11
3837 LGBTQ+ realities in the biological sciences
Cooper, K. M.; Busch, C. A.; Accorsi, A.; Applewhite, D. A.; Bhanderi, P. B.; da Rocha-Azevedo, B.; Roy, A. D.; Campanale, J. P.; Chang, F.; Chipuk, J. E.; Ligon, L. A.; Luxton, G. G.; Graham, A. J.; Hochman-Mendez, C.; Ozugergin, I.; Park, Z. M.; Thomas, C. M.; Valm, A. M.; Zhu, H.; Alvania, R. S.
10.1101/2025.01.24.634486 — scientific communication and education — Posted on 2025-03-11
3838 Bacteria use processing body condensates to attenuate host translation during infection
Gonzalez-Fuente, M.; Schulz, N.; Abdrakhmanov, A.; Izzati, G.; Zhu, S.; Langin, G.; Gouguet, P.; Franz-Wachtel, M.; Macek, B.; Hafren, A.; Dagdas, Y.; Üstün, S.
10.1101/2025.01.09.632196 — plant biology — Posted on 2025-03-11
3843 DEVELOPMENT OF A CONSENSUS MOLECULAR CLASSIFIER FOR PANCREATIC DUCTAL ADENOCARCINOMA
Villoslada-Blanco, P.; Alonso, L.; Sabroso-Lasa, S.; Maquedano, M.; Estudillo, L.; Real, F. X.; Lopez de Maturana, E.; Malats, N.
10.1101/2025.03.06.641837 — bioinformatics — Posted on 2025-03-11
3845 IAN: An Intelligent System for Omics Data Analysis and Discovery
Nagarajan, V.; Shi, G.; Horai, R.; Yu, C.-R.; Gopalakrishnan, J.; Yadav, M.; Liew, M.; Gentilucci, C.; Caspi, R. R.
10.1101/2025.03.06.640921 — bioinformatics — Posted on 2025-03-11
3848 MS/MS Mass Spectrometry Filtering Tree for Bile Acid Isomer Annotation.
Mohanty, I.; Xing, S.; Castillo, V.; Agongo, J.; Patan, A.; El Abiead, Y.; Mannochio-Russo, H.; Zuffa, S.; Zemlin, J.; Tronel, A.; Le Gouellec, A.; Soranzo, T.; Wang, C. X.; Iudicello, J. E.; Andalibi, M. S.; Ellis, R. J.; Moore, D. J.; Franklin, D. R.; Sala-Climent, M.; Guma, M.; Voigt, R. M.; Kaddaruh-Dauok, R.; Siegel, D.; Wang, M.; Hagey, L. R.; Dorrestein, P. C.
10.1101/2025.03.04.641505 — bioinformatics — Posted on 2025-03-11
3850 Whole-miRNome sequencing (WMS) - a panel for targeted sequencing of all human miRNA genes
Galka-Marciniak, P.; Urbanek-Trzeciak, M. O.; Kuznicki, D.; Szostak, N.; Tire, A.; Nawrocka-Muszynska, P. M.; Chojnacka, K.; Suszynska, M.; Klonowska, K.; Czubak, K.; Machowska, M.; Philips, A.; Maksin, K.; Susok, L.; Sand, M.; Rys, J.; Jura, J.; Ratajska, M.; Dams-Kozlowska, H.; Kowalewski, J.; Lewandowska, M. A.; Kozlowski, P.
10.1101/2025.03.09.641621 — genomics — Posted on 2025-03-11
3851 Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy
Amrute, J. M.; Jung, I.-H.; Yamawaki, T.; Bredemeyer, A.; Diekmann, J.; Hayat, S.; Lin, W.-L.; Zhang, X.; Luo, X.; Maryam, S.; Heo, G. S.; Yang, S.; Lee, C. J. M.; Chou, C.; Kuppe, C.; Cook, K. D.; Kovacs, A.; Chintalgattu, V.; Pruitt, D.; Barreda, J.; Stitziel, N. O.; Cheng, P.; Liu, Y.; Kramann, R.; Foo, R. S.-Y.; Rulifson, I. C.; Thomas, M.; Cui, J.; Quertermous, T.; Bengel, F. M.; Jackson, S.; Li, C.-M. K.; Ason, B.; Lavine, K. J.
10.1101/2025.03.03.641211 — genomics — Posted on 2025-03-11
3852 Rapidly evolved genomic regions shape individual language abilities in present-day humans
Casten, L. G.; Koomar, T.; Thomas, T. R.; Koh, J.-Y.; Hofammann, D.; Thenuwara, S.; Momany, A.; O'Brien, M.; Murray, J. C.; Tomblin, J. B.; Michaelson, J. J.
10.1101/2025.03.07.641231 — evolutionary biology — Posted on 2025-03-11
3854 Synchronized Temporal-spatial Analysis via Microscopy and Phoshoproteomics (STAMP) of Quiescence
Aziz-Zanjani, M. O.; Turn, R. E.; Asthana, A.; Linde-Garelli, K. Y.; Xu, L. A.; Labrie, L.; Mobedi, M.; Jackson, P. K.
10.1101/2024.06.24.600542 — cell biology — Posted on 2025-03-11
3856 Blastocoel fluid RNA predicts pregnancy outcome in assisted reproduction
Frisendahl, C.; Gemzell-Danielsson, K.; Nair, K.; Koch, F.; Menezes, J.; Sheiki, M.; Dahlgren, K.; Alnahal, W.; Lindgren, K.; Bohlin, T.; Olofsson, J.; Tohonen, V.; Vafaee, F.; Grace, L. P.; Boggavarapu, N. R.; Faridani, O. R.
10.1101/2025.03.09.641486 — molecular biology — Posted on 2025-03-11
3857 A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
Pons-Grifols, A.; Tarres-Freixas, F.; Perez, M.; Riveira-Munoz, E.; Raich-Regue, D.; Perez-Zsolt, D.; Munoz-Basagoiti, J.; Tondelli, B.; Pradenas, E.; Izquierdo-Useros, N.; Capdevila, S.; Vergara-Alert, J.; Urrea, V.; Carrillo, J.; Ballana, E.; Forrow, S.; Clotet, B.; Segales, J.; Trinite, B.; Blanco, J.
10.1101/2024.06.11.598471 — microbiology — Posted on 2025-03-11
3858 A Conditional Cas9 System for Stage-Specific Gene Editing in P. falciparum
Windle, S. T.; Neal, M. L.; Mast, F. D.; Kappe, S. H. I.; Aitchison, J. D.
10.1101/2025.03.09.642268 — microbiology — Posted on 2025-03-11
3859 Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing
Springe, M. L.; Vaivode, K.; Saksis, R.; Vainselbauma, N. M.; Ansone, L.; Briviba, M.; Niedra, H.; Rovite, V.
10.1101/2025.03.05.641671 — immunology — Posted on 2025-03-11
3860 TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells
Lee, H.; Kim, S.-Y.; Kim, S.-H.; Yu, H.; Jeong, S.; Kim, K. H.; Kim, C. G.; Koh, J.-Y.; Kim, H.-D.; Han, J. W.; Min, S.; Park, S.-H.; Eun, H. S.; Shin, E.-C.
10.1101/2025.01.13.632884 — immunology — Posted on 2025-03-11
3861 Ultrasound Directly Activates Sparse Neurons and Modulates Visual Circuits in Deafened Mice
He, J.; ZHU, J.; Wang, X.; Chen, Z.; Yang, J.; Yuan, Z.; Xu, H.; Sun, L.; Qiu, Z.
10.1101/2025.03.09.642207 — neuroscience — Posted on 2025-03-11
3863 A half-centre oscillator encodes sleep pressure
Hasenhuetl, P. S.; Sarnataro, R.; Vrontou, E.; Rorsman, H. O.; Talbot, C. B.; Brain, R.; Miesenboeck, G.
10.1101/2024.02.23.581780 — neuroscience — Posted on 2025-03-11
3867 SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy.
Ferreira, J. J.; Kent, L. N.; McCarthy, R.; Butler, A.; Ma, X.; Paramsetty, N.; Amazu, C.; Zhang, A.; Whitter, G. C.; Li, E.; England, S. K.; Santi, C. M.
10.1101/2024.05.29.596465 — physiology — Posted on 2025-03-11
3868 Plasma, not extracellular vesicles, disrupts the blood-brain barrier in eclampsia.
Acurio, J.; Troncoso, F.; Escudero-Guevara, E. A.; Sandoval, H.; Vatish, M.; Torres-Vergara, P.; Bergman, L.; Escudero, C.
10.1101/2025.03.03.641338 — physiology — Posted on 2025-03-11
3870 A model for boundary-driven tissue morphogenesis
Alber, D. S.; Zhao, S.; Jacinto, A. O.; Wieschaus, E. F.; Shvartsman, S. Y.; Haas, P. A.
10.1101/2025.03.05.641672 — biophysics — Posted on 2025-03-11
3874 Decoding heart failure subtypes with neural networks via differential explanation analysis
Ruz Jurado, M.; Rodriguez Morales, D.; Genetzakis, E.; Ardakani, F. B.; Zanders, L.; Fischer, A.; Buettner, F.; Schulz, M. H.; Dimmeler, S.; John, D.
10.1101/2025.03.03.641151 — bioinformatics — Posted on 2025-03-11
3877 Enzyme Co-Scientist: Harnessing Large Language Models for Enzyme Kinetic Data Extraction from Literature
Jiang, J.; Hu, J.; Xie, S.; Guo, M.; Dong, Y.; Fu, S.; Jiang, X.; Yue, Z.; Shi, J.; Zhang, X.; Song, M.; Chen, G.; Lu, H.; Wu, X.; Guo, P.; Han, D.; Sun, Z.; Qiu, J.
10.1101/2025.03.03.641178 — biochemistry — Posted on 2025-03-11
3878 BAHD news from Euphorbia peplus: identification of acyltransferase enzymes involved in ingenane diterpenoid biosynthesis
Schotte, C.; Florean, M.; Czechowski, T.; Gilday, A.; Alam, R.; Ploss, K.; Wurlitzer, J.; Li, Y.; Sonawane, P.; Graham, I. A.; O'Connor, S. E.
10.1101/2025.03.03.641262 — biochemistry — Posted on 2025-03-11
3879 Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins
Gustafsen, C.; Vilstrup, J.; Kristensen, M.; Koster, D.; Lende, J.; Larsen, C.; Simonsen, A.; Graversen, A.; Olsen, D.; Pallesen, L. T.; Vaegter, C.; Etzerodt, A.; Qureshi, O.; Harrison, N.; Cowley, J.; Barnes, N.; Mazarakis, S.; Greve, D.; Quattropani, A.; Glossop, P.; Whitlock, G.; Jensen, K.; Nielsen, S. F.; Madsen, P.; Glerup, S.
10.1101/2025.03.03.641244 — biochemistry — Posted on 2025-03-11
3881 Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes
Koller, M. S.; Himmelbauer, C.; Fink, S.; Ravichandran, M. C.; Campbell, C.
10.1101/2025.03.05.641640 — genetics — Posted on 2025-03-11
3882 Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster
Hubert, D. L.; Arnold, K. R.; Greenspan, Z. S.; Pupo, A.; Robinson, R. D.; Chavarin, V. V.; Barter, T. T.; Djukovic, D.; Raftery, D.; Vue, Z.; Hinton, A.; McReynolds, M. R.; Harrison, B. R.; Phillips, M. A.
10.1101/2024.06.28.601037 — evolutionary biology — Posted on 2025-03-11
3885 Coupling of cell proliferation to the segmentation clock ensures robust somite scaling
van Oostrom, M. J.; Li, Y. I.; Meijer, W. H. M.; Noordzij, T. E. J. C.; Fountas, C.; Timmers, E.; Korving, J.; Thomas, W. M.; Simons, B. D.; Sonnen, I.
10.1101/2025.01.10.632257 — developmental biology — Posted on 2025-03-11
3886 The TONSL-MMS22L complex and FANCM form an interdependent complex on chromatin to counter replication stress
Zhou, H.; Yan, J.; Cao, X.; Zhan, J.; Ling, C.; Luo, Y.; Ma, Z.; Sun, Y.; Song, P.; Liu, W.; Wang, L.; Li, J.; Shaik, A.; Bellani, M.; Wang, L.; Xie, Y.; Zhang, J.; Xue, X.; Shen, X.; Seidman, M. M.; Wang, W.; Yan, Z.
10.1101/2025.03.07.642025 — cell biology — Posted on 2025-03-11
3887 An independently tunable dual control system for RNAi complementation in Trypanosoma brucei
Armstrong, R.; Romprey, M. J.; Raughley, H. M.; Delzell, S. B.; Frost, M. P.; Chambers, J.; Garman, G. G.; Anaguano, D.; Klingbeil, M.
10.1101/2025.03.06.641967 — molecular biology — Posted on 2025-03-11
3889 Agriculturally sourced multidrug-resistant Escherichia coli for use as control strains
Wells, J. E.; Durso, L. M.; Ibekwe, A. M.; Frye, J. G.; Sharma, M.; Williams, C. F.; Shamimuzzaman, M.
10.1101/2025.03.07.641915 — microbiology — Posted on 2025-03-11
3890 DZNep-induced single point mutation (M236I) in poxviral 2'-O-methyltransferase enhances mRNA stability and translation efficiency
VERMA, A.; Jangir, R. K.; Kamboj, H.; Kumar, G.; Meena, V. K.; Sharma, V.; Bhattacharaya, T. K.; Tripathi, B. N.; Sharma, S.; Kumar, N.
10.1101/2025.03.10.642379 — microbiology — Posted on 2025-03-11
3891 Solid-State NMR Analysis of Schizosaccharomyces pombe Reveals Role of α-Amylase Family Enzymes in Cell Wall Structure and Function
Jacob, A.; Willet, A. H.; Igarashi, M. G.; El Nokab, M. E. H.; Turner, L. A.; Alsanad, A. K. A.; Wang, T.; Gould, K. L.
10.1101/2025.03.10.642465 — microbiology — Posted on 2025-03-11
3892 The protease inhibitor Nirmatrelvir synergizes with inhibitors of GRP78 to suppress SARS-CoV-2 replication
Al Krad, D.; Stegmann, K. M.; Dickmanns, A.; Blaurock, C.; Mohl, B.-P.; Wille, S. J.; Breithaupt, A.; Britzke, T.; Balkema-Buschmann, A.; Dobbelstein, M.
10.1101/2025.03.09.642200 — microbiology — Posted on 2025-03-11
3894 Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response
Remick, B. C.; Mao, J. Q.; Manford, A. G.; Gutierrez-Jensen, A. D.; Wagner, A.; Rape, M.; McFadden, G.; Rahman, M. M.; Gaidt, M. M.; Vance, R. E.
10.1101/2025.03.04.641538 — immunology — Posted on 2025-03-11
3897 Psychedelics Align Brain Activity with Context
Stoliker, D.; Novelli, L.; Khajehnejad, M.; Biabani, M.; Barta, T.; Greaves, M. D.; Williams, M.; Chopra, S.; Bazin, O.; Simonsson, O.; Chambers, R.; Barrett, F.; Deco, G.; Seth, A.; Preller, K. H.; Carhart-Harris, R.; Sundram, S.; Egan, G. F.; Razi, A.
10.1101/2025.03.09.642197 — neuroscience — Posted on 2025-03-11
3899 Paradoxical ventral tegmental area GABA signaling drives enhanced morphine reward after adolescent nicotine
Wittenberg, R. E.; Yun, S.; Yang, K.; Swanson, O. K.; Wolfman, S. L.; Colon, L. M.; Eisch, A. J.; Dani, J. A.
10.1101/2025.03.09.642288 — neuroscience — Posted on 2025-03-11
3900 Impaired capillary-venous drainage contributes to gliosis and demyelination in white matter during aging
Stamenkovic, S.; Schmid, F.; Gurler, G.; Abolmaali, F.; Weitermann, N.; Takasaki, K. T.; Bonney, S. K.; Sosa, M. J.; Bennett, H. C.; Kim, Y.; Waters, J.; Shih, A.
10.1101/2024.02.11.579849 — neuroscience — Posted on 2025-03-11
3901 Cell-specific inhibitory modulation of sound processing in the auditory thalamus.
Rolon-Martinez, S.; Mendoza, A. J.; Angeloni, C. F.; Chen, R.; Vu, K.; Haas, J. S.; Geffen, M. N.
10.1101/2024.06.29.601250 — neuroscience — Posted on 2025-03-11
3903 A strategy for genome-wide seamless tagging of human protein-coding genes
Karimi, M.; Saber, M. M.; Stifani, N.; Gauthier, L.; Serohijos, A. W.; Michnick, S. W.
10.1101/2025.03.04.641506 — systems biology — Posted on 2025-03-11
3909 Guiding eQTL mapping and genomic prediction of gene expression in three pig breeds with tissue-specific epigenetic annotations from early development
Mollandin, F.; Acloque, H.; Ballester, M.; Bink, M.; Calus, M.; Crespo Piazuelo, D.; Croiseau, P.; Djebali, S.; Foissac, S.; Gilbert, H.; Giuffra, E.; Guyomar, C.; Madsen, O.; Mercat, M.-J.; da Costa Perez, B.; de Vos, J.; Rau, A.
10.1101/2025.03.05.641618 — genomics — Posted on 2025-03-11
3910 Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples
Chaudhary, O.; Steinberg, M.; Duclos, G.; Gathungu, P.; Rao, M.; Aguilar, R.; Shankarappa, V.; Rands, C.; Chen, X.; Halpin, R.; Galery, E.; Boland, J.; Scaltriti, M.; Dougherty, B.; Rotem, A.
10.1101/2025.03.06.641241 — genomics — Posted on 2025-03-11
3911 BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD
Tran, U.; Streets, A. J.; Smith, D.; Decker, E.; Kirschfink, A.; Izem, L.; Hassey, J.; Ruthland, B.; Valluru, M. K.; Bräsen, J. H.; Ott, E.; Epting, D.; Eisenberger, T.; Ong, A. C.; Bergmann, C.; Wessely, O.
10.1101/2024.08.27.608867 — genetics — Posted on 2025-03-11
3913 Soil microbiomes reveal different strategies for nitrogen acquisition in aspen-dominated stands from Mexico and Canada
Fijarczyk, A.; Goessen, R.; Morency, M.-J.; Gagne, P.; Laganiere, J.; Wehenkel, C.; Hernandez-Velasco, J.; Porth, I.; Isabel, N.; Martineau, C.
10.1101/2025.03.05.641730 — evolutionary biology — Posted on 2025-03-11
3914 Prediction of mosquito vector abundance for threespecies in the Anopheles gambiae complex
Hosack, G. R.; El-Hachem, M.; Ickowicz, A.; Beeton, N. J.; Wilkins, A.; Hayes, K. R.; Rund, S. S. C.; Kelly, S. A.; McDowell, M. A.
10.1101/2025.03.04.641552 — ecology — Posted on 2025-03-11
3916 Above- and below-ground trait coordination across 90 angiosperm and gymnosperm tree species
Sanaei, A.; Andraczek, K.; Kretz, L.; Schnabel, F.; Richter, R.; Kahl, A.; Nabel, N.; von_Sivers, L.; Künne, T.; Leonore.van_braak, J.; Felicitas Hofmann, R.; Sophie Hensel, C.; Mora, K.; Feilhauer, H.; Wirth, C.; Weigelt, A.
10.1101/2025.03.05.641585 — ecology — Posted on 2025-03-11
3917 Elusive tropical forest canopy diversity revealed through environmental DNA contained in rainwater
Zinger, L.; Benoiston, A.-S.; Cuenot, Y.; Leroy, C.; Louisanna, E.; Moreau, L.; Petitclerc, F.; Piatscheck, F.; Orivel, J.; Richard-Hansen, C.; Hansen-Chaffard, L.; Troispoux, V.; Boyer, F.; Chave, J.; Decaens, T.; Fouquet, A.; Pansu, J.; Raynaud, J.; Rougerie, R.; Sire, L.; Schimann, H.; Taberlet, P.; Iribar, A.
10.1101/2025.02.26.640397 — ecology — Posted on 2025-03-11
3918 Uncovering synaptic and cellular nanoarchitecture of brain tissue via seamless in situ trimming and milling for cryo-electron tomography
Ning, J.; Glausier, J. R.; Warshamanage, R.; Gunther-Cummins, L.; Burnley, T.; Palmer, C. M.; Gonzalez-Burgos, G.; Miyamae, T.; Wang, J.; Carlisle, D.; Hsieh, C.; Schmelzer, T.; Buck, S. A.; Franks, J.; Hampton, C. M.; Stauffer, W. R.; Lewis, D. A.; Friedlander, R. M.; Macaluso, F. P.; Winn, M.; Freyberg, Z.
10.1101/2025.03.09.642162 — cell biology — Posted on 2025-03-11
3919 The NAT10 acetyltransferase modulates DNA damage-related factors and global 3D-genome architecture
Bartova, E.; Skalnikova, M.; Stixova, L.; Tichy, V.; Opaleny, F.; Byska, J.; Brom, T.; Legartova, S.
10.1101/2025.03.05.641614 — cell biology — Posted on 2025-03-11
3920 Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection
Panthi, A.; Ferretti, M. B.; Howard, O.; Pokharel, S. M.; McCracken, R.; Quesnel-Vallieres, M.; Li, Q.; Cherry, S. R.; Lynch, K. W.
10.1101/2025.03.10.642367 — molecular biology — Posted on 2025-03-11
3923 Lipopolysaccharide lateral mobility in the Gram-negative bacterial outer membrane is confined and governed by interactions within the conserved Lipid A anchor
Nabarro, J.; Leaman, R. M.; Lenton, S.; Mantion, L.; Spears, R. J.; Coles, M. C.; Pushkin, D. O.; Fascione, M. A.; Baumann, C. G.
10.1101/2025.03.10.642448 — microbiology — Posted on 2025-03-11
3924 The pre-mRNA Splicing Modulator Pladienolide B Inhibits Cryptococcus neoformans Germination and Growth
Love, S. L.; McKeon, M. C.; Vollmer, H.; Paulson, J. C.; Oshimura, N.; Valentine, O.; Ortiz, S. C.; Hull, C. M.; Hoskins, A.
10.1101/2025.03.06.641977 — microbiology — Posted on 2025-03-11
3925 Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin
Sia, C. M.; Ambrose, R. L.; Valcanis, M.; Andersson, P.; Ballard, S. A.; Howden, B. P.; Williamson, D. A.; Pearson, J. S.; Ingle, D. J.
10.1101/2024.07.30.605691 — microbiology — Posted on 2025-03-11
3926 Snapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection
Kotova, I.; Muehlberg, L.; Gilep, K.; Yu, D.; Ziemianowicz, D.; Stanelle-Bertram, S.; Beck, S.; Baeg, K.; Duss, O.; Gabriel, G.; Liu, F.; Bogdanow, B.; Kosinski, J.
10.1101/2025.03.09.642134 — microbiology — Posted on 2025-03-11
3927 Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata
Steenbuck, N.; Damond, N.; Engler, S.; Kusmartseva, I.; Posgai, A. L.; Drotar, D. M.; Williams, M. D.; de Souza, N.; Brusko, T. M.; Brusko, M. A.; Wasserfall, C. H.; Atkinson, M. A.; Bodenmiller, B.
10.1101/2025.03.05.641526 — immunology — Posted on 2025-03-11
3928 A Novel Glia-immune humanized mouse model for investigation of HIV CNS infection and neuroinflammation.
Tomer, S.; Pan, L.; Harding, J.; Rezek, V.; Krawczyk, M.; Cook, E.; Kedia, N.; Wang, L.; Le, J.; Martin, H.; Gramajo, E.; Li, X.; Zhang, Y.; Wen, J.; Kitchen, S.; Zhang, Y.; Zhen, A.
10.1101/2025.03.05.641678 — immunology — Posted on 2025-03-11
3929 Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions
Mil, J.; Soto, J. A.; Matulionis, N.; Krall, A.; Day, F.; Stiles, L.; Montales, K. P.; Azizad, D. J.; Gonzalez, C. E.; Nano, P. R.; Martija, A. A.; Perez-Ramirez, C. A.; Nguyen, C. V.; Kan, R. L.; Andrews, M. G.; Christofk, H. A.; Bhaduri, A.
10.1101/2025.03.10.642470 — neuroscience — Posted on 2025-03-11
3931 Local and distributed information coding in the ventral stream
Bogdan, P. C.; Howard, C.; Gillette, K.; Cabeza, R.; Davis, S. W.
10.1101/2025.03.09.642235 — neuroscience — Posted on 2025-03-11
3933 Towards an informed choice of diffusion MRI image contrasts for cerebellar segmentation
Legarreta, J. H.; Lan, Z.; Chen, Y.; Zhang, F.; Yeterian, E.; Makris, N.; Rushmore, R. J.; Rathi, Y.; O'Donnell, L. J.
10.1101/2025.03.10.642452 — neuroscience — Posted on 2025-03-11
3934 High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease
Cardona, C. L.; Wei, L.; Kim, J.; Angeles, E.; Singh, G.; Chen, S.; Ifediora, N.; Canoll, P.; Teich, A. F.; Hargus, G.; Chavez, A.; Sproul, A. A.
10.1101/2025.03.09.642133 — neuroscience — Posted on 2025-03-11
3935 Mitochondrial origins of the pressure to sleep
Sarnataro, R.; Velasco, C. D.; Monaco, N.; Kempf, A.; Miesenboeck, G.
10.1101/2024.02.23.581770 — neuroscience — Posted on 2025-03-11
3936 Global Neuron Shape Reasoning with Point Affinity Transformers
Troidl, J.; Knittel, J.; Li, W.; Zhan, F.; Pfister, H.; Turaga, S. C.
10.1101/2024.11.24.625067 — neuroscience — Posted on 2025-03-11
3937 Alternative polyadenylation regulates human urothelial differentiation
Le, N. B.; Sona, S.; Santo, B.; Schweickart, R. A.; Kochat, V.; Padron, W.; Rai, K.; Lee, S.-H.; Yi, J. M.; Wessely, O.; Lee, B. H.; Ting, A. H.
10.1101/2025.03.03.641311 — systems biology — Posted on 2025-03-11
3938 Multi-Coloured Sequential Resonance Energy Transfer for Simultaneous Ligand Binding at G Protein-Coupled Receptors
Valentini, A.; Dibnah, B.; Ciba, M.; Duncan, E. M.; Manandhar, A.; Strellis, B.; Vita, L.; Lucianno, O.; Massey, C.; Coe, S.; Ulven, T.; Hudson, B. D.; Rexen Ulven, E.
10.1101/2024.08.07.606978 — pharmacology and toxicology — Posted on 2025-03-11
3940 Aquaporin-1 sustains lymphangiogenic responses in inflammatory microenvironments
Roci, I.; Kim, J.; de Korodi, K.; Wyss, T.; Bernier-Latmani, J.; Arroz-Madeira, S.; Bovay, E.; Schoofs, H.; Makinen, T.; Noel, A.; Petrova, T. V.
10.1101/2025.03.05.641652 — pathology — Posted on 2025-03-11
3944 Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin
Zoi, I.; Rajput, M.; Holguin-Horcajo, A.; Haidar, M.; Brusa, D.; Chu, K.; Xie, J.; Shields, M.; Morgadinho Ferreira, S.; Stanger, B.; Attardi, L. D.; Kopp, J.; Stemmler, M. P.; Nicolle, R.; Rovira, M.; Jacquemin, P.
10.1101/2025.03.07.642043 — cancer biology — Posted on 2025-03-11
3945 Novel peptide targeting CXCR4 disrupt tumor-stroma crosstalk to eliminate migrating cancer stem cells
Tiwary, K.; Lahusen, A.; Inaas, S.; Beitzinger, B.; Schmid, R.; Harms, M.; Hauff, S.; Arnold, F.; Walter, K.; Alcala, S.; Hahn, S. A.; Hessmann, E.; Kleger, A.; Azoitei, N.; Seufferlein, T.; Sainz Anding, B.; Muench, J.; Linden, M.; Hermann, P. C.
10.1101/2025.03.03.641126 — cancer biology — Posted on 2025-03-11
3948 D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes
Kearns, F.; Bogetti, A.; Calvo-Tussell, C.; Braza, M. K.; Casalino, L.; Gramm, A. J.; Braet, S. M.; Rosenfeld, M.; Rajapaksha, H.; Barker, B.; Anand, G. S.; Chong, L.; Ahn, S.-H.; Amaro, R. E.
10.1101/2025.03.07.642081 — biophysics — Posted on 2025-03-11
3949 Structural insights into the ubiquitin independent MIDN-proteasome pathway
Peddada, N.; Zhong, X.; Yin, Y.; Lazaro, D. R.; Wang, J.; Lyon, S.; Choi, J. H.; Bai, X.; Moresco, E. M. Y.; Beutler, B.
10.1101/2025.03.04.641557 — biophysics — Posted on 2025-03-11
3950 Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment
Su, Q. P. P.; Sun, Y.; Zhang, M.; Zhao, W.; Xiao, Z.; Chang, L.; Wang, X.; Bai, Y.; Guan, X.; Liu, T.; Li, Y.; Li, Q.; Li, C.; Xu, D.
10.1101/2025.03.06.641818 — biophysics — Posted on 2025-03-11
3953 High-resolution HIV-1 m6A epitranscriptome reveals splicing-dependent methylation clusters and unique 2-LTR transcript modifications
Naquin, D.; Blanchet, S.; van Dijk, E.; Bertrand, L.; Gregoire, S.; Ramirez, C.; Ouazahrou, R.; Jaszczyszyn, Y.; Moris, A.; Thermes, C.; Hernandez, C.; NAMY, O.
10.1101/2025.03.06.641803 — bioinformatics — Posted on 2025-03-11
3954 Cell morphological representations of genes enhance prediction of drug targets
Iyer, N. S.; Michael, D. J.; Chi, S.-Y. G.; Arevalo, J.; Chandrasekaran, S. N.; Carpenter, A. E.; Rajpurkar, P.; Singh, S.
10.1101/2024.06.08.598076 — bioinformatics — Posted on 2025-03-11
3955 Structural conformations of intrinsically disordered proteins of podocyte slit-diaphragm
Padmanaban, H. K.; Bheemireddy, S.; Mulukala, S. K.; Dunna, N. R.; Pasupulati, A. k.
10.1101/2025.03.04.641475 — bioinformatics — Posted on 2025-03-11
3956 Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology
Maiti, S.; Tripathi, S.; Baggett, D. W.; Phillips, A. H.; Park, C.-G.; Wang, J.; Wahiduzzaman, F.; Freyaldenhoven, W. T.; Kinger, S.; Pioso, B.; Bollinger, J.; Somjee, R.; Lang, B.; Babu, M. M.; Kriwacki, R. W.
10.1101/2025.03.03.640993 — bioinformatics — Posted on 2025-03-11
3961 Anticlustering for Sample Allocation To Minimize Batch Effects
Papenberg, M.; Wang, C.; Diop, M.; Bukhari, S. H.; Oskotsky, B.; Davidson, B. R.; Vo, K. C.; Liu, B.; Irwin, J. C.; Combes, A.; Gaudilliere, B.; Li, J.; Stevenson, D. K.; Klau, G. W.; Giudice, L. C.; Sirota, M.; Oskotsky, T. T.
10.1101/2025.03.03.641320 — bioinformatics — Posted on 2025-03-11
3967 Hyaluronic Acid-Coated Melt Electrowritten Scaffolds Promote Myoblast Attachment, Alignment, and Differentiation
Galindo, A. N.; Chi, A. K.; Liashenko, I.; O'Neill, K. L.; Sharma, R.; Khachatourian, J. D.; Hajarizadeh, A.; Dalton, P. D.; Hettiaratchi, M. H.
10.1101/2025.03.06.641880 — bioengineering — Posted on 2025-03-11
3968 A pharmacological modality to sequester homomeric proteins
Livnah, E.; Suss, O.; Rogel, A.; Gilat, A.; Abdan, Y.; Villegas, J. D.; Tivon, B.; Albeck, S.; Unger, T.; Golani, O.; Goliand, I.; Margulies, D.; Levy, E. D.; London, N.
10.1101/2025.03.05.641597 — biochemistry — Posted on 2025-03-11
3969 Thin-diaPASEF: diaPASEF for maximizing proteome coverage in single-shot proteomics
Konno, R.; Ishikawa, M.; Nakajima, D.; Inukai, K.; Ohara, O.; Kawashima, Y.
10.1101/2024.04.26.591246 — biochemistry — Posted on 2025-03-11
3970 Biodegradable Poly(β-amino amide)s Enable Efficient RNA Delivery and Spleen Targeting
Yang, X.; Xiao, J.; Zhai, Y.; Liao, L.; Qiu, H.; Chen, Y.; Staveness, D.; Zang, X.
10.1101/2025.03.03.641302 — biochemistry — Posted on 2025-03-11
3974 Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read sequencing
Trinh, A.; Akhtar, N.; Bonsu, K.; Laszik, N.; Mendelevich, A.; Wen, T.; Morival, J. L. P.; Diune, K. E.; Frazeur, M.; Vega, J. E.; Gimelbrant, A.; Read, E. L.; Downing, T. L.
10.1101/2025.03.03.641287 — genomics — Posted on 2025-03-11
3976 Transgenerational maintenance of H3K27me3 heterochromatin is balanced by chromodomain proteins in Caenorhabditis elegans
Ozdemir, I.; Hoefler, A.; Delaney, K.; Wenda, J. M.; Li, C.; Saltzman, A. L.; Boland, A.; Steiner, F. A.
10.1101/2025.03.07.642071 — genetics — Posted on 2025-03-11
3977 Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing
Malinsky, M.; Talbi, M.; Zhou, C.; Maurer, N. W.; Sacco, S.; Shapiro, B.; Peichel, C. L.; Seehausen, O.; Salzburger, W.; Weber, J. N.; Bolnick, D. I.; Green, R. E.; Durbin, R.
10.1101/2025.03.06.641907 — genetics — Posted on 2025-03-11
3978 A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition
Myers, L. S.; Christian, S. G.; Simpson, S.; Sper, R.; Taylor, C.; Montes, L.; Jepp, T. B. C.; Ramos, D.; Schuller, L.; Konganti, K.; Friedeck, W.; Habib, O.; Hodge, M.; Taylor, A. J.; Coffell, A.; Schlafer, A.; Matt, M.; Revell, B.; Knight, C.; Barrena, C. C.; FAST Integrative Research Environment (FIRE) Initiative, ; Murphy, W. J.; Piedrahita, J.; Dindot, S. V.
10.1101/2025.03.04.641215 — genetics — Posted on 2025-03-11
3979 The epigenetic reader MORC3 is required for T cell development in the thymus
Della Chiara, V.; Vukic, M.; Chouaref, J.; Garcia-Perez, L.; Naber, G.; Vonk, K. K. D.; Leemans, C.; Kovynev, A.; Zhong, Z.; Breukel, C.; Vloemans, S. G.; Cante-Barrett, K.; Pike-Overzet, K.; Jacobsen, S. E.; Staal, F. J. T.; Daxinger, L.
10.1101/2025.03.05.641591 — genetics — Posted on 2025-03-11
3981 Odorant receptors tuned to isothiocyanates in Drosophila melanogaster are co-opted and expanded in herbivorous relatives
Matsunaga, T.; Reisenman, C. E.; Goldman-Huertas, B. M.; Rajshekar, S.; Suzuki, H. C.; Tadres, D.; Wong, J.; Louis, M.; Ramirez, S. R.; Whiteman, N. K.
10.1101/2024.10.08.617316 — evolutionary biology — Posted on 2025-03-11
3987 Refining the resistance-to-damage (RD) score to predict operational Insecticide-Treated Net lifespan and identify paths to innovation
Mechan, F.; Poyer, S.; Tangena, J.-A. A.; Worges, M.; Sternberg, E.; Kilian, A.; Koenker, H.; Wheldrake, A.; Junaid, F.; Russell, S.; Fornadel, C.; Spiers, A.
10.1101/2025.03.02.641027 — ecology — Posted on 2025-03-11
3989 Environmental NaCl affects C. elegans development and aging
Pohl, F.; Egan, B. M.; Schneider, D. L.; Mosley, M. C.; Garcia, M. A.; Hou, S.; Chiu, C.-H.; Kornfeld, K.
10.1101/2025.03.09.641258 — developmental biology — Posted on 2025-03-11
3990 Competition for microtubule lattice spacing between a microtubule expander and compactor.
Paquette, A. L.; Cruz Tetlalmatzi, S.; Haineault, J. A. G.; Hendricks, A. G.; Brouhard, G. J.; Sebastien, M.
10.1101/2025.02.28.640185 — cell biology — Posted on 2025-03-11
3998 Deciphering the role of histo-blood group antigens in bovine rotavirus C infection
Navarro-Lleo, N.; Ramirez-Cardenas, J.; Paredes-Martinez, F.; Serna, S.; Gozalbo-Rovira, R.; Munoz-Garcia, J. C.; Reichardt, N. C.; Casino, P.; Angulo, J.; Rodriguez-Diaz, J.; Buesa, J.
10.1101/2025.03.10.642353 — microbiology — Posted on 2025-03-11
4000 Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody
Rao, V. N.; Sapse, I. A.; Cohn, H.; Yoo, D.-K.; Tong, P.; Clark, J.; Bozarth, B.; Chen, Y.; Srivastava, K.; Singh, G.; Krammer, F.; Simon, V.; Wesemann, D. R.; Bajic, G.; Coelho, C. H.
10.1101/2025.03.07.642041 — immunology — Posted on 2025-03-11
4001 Malignant ascites enhance γδ T cell cytotoxicity towards ovarian cancer via modulating chemokines secretion from the cancer cells that recruits γδ T cells
Zhanqun, Y.; Ying, L.; Mengzhu, Z.; Hui, L.; Ruoyao, C.; Pan, W.; Tianhui, H.; Hongyan, G.; Yinglin, Z.; Jian, L.; Long, C.
10.1101/2025.03.05.641778 — immunology — Posted on 2025-03-11
4002 Olfactory receptor 2 drives abdominal aortic aneurysm by promoting CX3CR1-mediated monocyte recruitment
Schelemei, P.; Picard, f.; Park, Y.; Wollnitzke, P.; Nemade, H.; Mehrkens, D.; Arkenberg, P.; Rappenecker, A.; Wrobel, J.; Martinez Lagunas, K.; Wagner, E.; Guthoff, H.; Roy, J.; Lindquist Liljeqvist, M.; Ibing, W.; Wagenhäuser, M. U.; Schelzig, H.; Levkau, B.; Flögel, U.; Gerdes, N.; Karimpour, M.; Hillmer, A.; Sengle, G.; Megens, R. T.; Weber, C.; Orecchioni, M.; Baldus, S.; Mollenhauer, M.; Winkels, H.
10.1101/2025.02.28.640923 — immunology — Posted on 2025-03-11
4004 Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Emami Naeini, S.; Bhandari, B.; Hill, B.; Perez-Morales, N.; Rogers, H. M.; Khodadadi, H.; Young, N.; Maciel, L. M.; Yu, J. C.; Hess, D. C.; Morgan, J. C.; Lopes Salles, E.; Wang, L. P.; Baban, B.
10.1101/2025.03.06.641791 — immunology — Posted on 2025-03-11
4005 Likely circulation of a coronavirus in roe deer (Capreolus capreolus) populations suggested by SARS-CoV-2 serological investigation in France
Perez, G.; Lalande, L. D.; Legros, V.; Kodjo, A.; Verheyden, H.; Bourret, V.; Cebe, N.; Chaval, Y.; Revelli, P.; Pellerin, M.; Lemaitre, J.-F.; Peroz, C.; Rey, B.; Debias, F.; Garcia, R.; Bourgoin, G.; Gilot-Fromont, E.
10.1101/2025.02.19.639030 — immunology — Posted on 2025-03-11
4012 Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis
Tozlu, C.; Ong, D.; Piccirillo, C.; Schwartz, H.; Jaywant, A.; Nguyen, T.; Jamison, K. W.; Gauthier, S. A.; Kuceyeski, A.
10.1101/2025.03.07.642094 — neuroscience — Posted on 2025-03-11
4015 Brainstem circuit for sickness-induced sleep
Darmohray, D.; Yao, Y.; Sima, J.; Chen, C.-H.; Silverman, D.; Chen, C.; Dan, Y.
10.1101/2025.03.09.642181 — neuroscience — Posted on 2025-03-11
4017 Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice
Wang, D.; Li, H.; Zeng, Y.; Gao, J.; Xu, M.; Bo, B.; Pei, M.; Liang, Z.; Zhou, N.; Thompson, G. J.
10.1101/2025.03.08.641356 — neuroscience — Posted on 2025-03-11
4021 BROAD-NESS uncovers dual-stream mechanisms underlying predictive coding in auditory memory networks
Bonetti, L.; Fernandez-Rubio, G.; Andersen, M. H.; Malvaso, C.; Carlomagno, F.; Testa, C.; Vuust, P.; Kringelbach, M. L.; Rosso, M.
10.1101/2024.10.31.621257 — neuroscience — Posted on 2025-03-11
4022 iSCORE-PD: an isogenic stem cell collection to research Parkinson Disease
Busquets, O.; Li, H.; Syed, K. M.; Jerez, P. A.; Dunnack, J.; Bu, R. L.; Verma, Y.; Pangilinan, G. R.; Martin, A.; Straub, J.; Du, Y.; Simon, V. M.; Poser, S.; Bush, Z.; Diaz, J.; Sahagun, A.; Gao, J.; Hong, S.; Hernandez, D.; Levine, K. S.; Booth, E. O.; Blanchette, M.; Bateup, H.; Rio, D.; Hockemeyer, D.; Blauwendraat, C.; Soldner, F.
10.1101/2024.02.12.579917 — neuroscience — Posted on 2025-03-11
4024 Very long-chain ceramides in muscle associate with insulin resistance independent of obesity
Madsen, S.; Cutler, H. B.; Cooke, K. C.; Potter, M.; Khor, J.; Rau, c. D.; Masson, S. W. C.; Howell, A.; Modrusan, Z.; Don, A. S.; Stöckli, J.; Diaz-Vegas, A.; James, D. E.
10.1101/2025.03.04.641442 — systems biology — Posted on 2025-03-11
4025 Accelerating protein engineering with fitness landscape modeling and reinforcement learning
Sun, H.; He, L.; Deng, P.; Liu, G.; Zhao, Z.; Jiang, Y.; Cao, C.; Ju, F.; Wu, L.; Liu, H.; Qin, T.; Liu, T.-Y.
10.1101/2023.11.16.565910 — synthetic biology — Posted on 2025-03-11
4027 Abscisic acid and GIGANTEA signalling converge to regulate the recruitment of CONSTANS to the FT promoter and activate floral transition
Robustelli Test, A.; Perrella, G.; Landoni, B.; Colanero, S.; Sutti, A.; Korwin Krukowski, P.; Xu, T.; Vellutini, E.; Castorina, G.; Galbiati, M.; Martignago, D.; Kaiserli, E.; Tonelli, C.; Conti, L.
10.1101/2024.05.29.595696 — plant biology — Posted on 2025-03-11
4028 Characterisation of native human pancreatic mesenchymal stromal cells in type 1 diabetes
Dewhurst-Trigg, R. E.; Atkins, J.; Morgan, N. G.; Eichmann, M.; Richardson, S. J.; Rackham, C. L.
10.1101/2025.03.05.641596 — physiology — Posted on 2025-03-11
4029 Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses
Kercmar, J.; Murko, N.; Krizancic Bombek, L.; Paradiz Leitgeb, E.; Pfabe, J.; Postic, S.; Huang, Y.-C.; Stozer, A.; Korosak, D.; Kozisek, X.; Perisic, M.; Muttenthaler, M.; Gruber, C. W.; Slak Rupnik, M.
10.1101/2025.03.03.641205 — physiology — Posted on 2025-03-11
4030 Hypoxia responses in arginase 2 deficient mice enhance cardiovascular health
XU, W.; Asosingh, K.; Janocha, A. J.; Madden, E.; Wanner, N.; Trotter, D.; Novotny, M. V.; Mulya, A.; Farha, S.; Erzurum, S. C.
10.1101/2025.02.20.639297 — physiology — Posted on 2025-03-11
4032 Optimization and evaluation of complementary degrader discovery assays for application in screening
Huchting, J.; Weller, A.; Schweizer, M.; Brandt, M.; Heering, J.; Kuzikov, M.; Wolf, M.; Reinshagen, J.; Queisser, M. A.; Gribbon, P.; Zaliani, A.; Pless, O.; Kannt, A.
10.1101/2025.03.06.641606 — pharmacology and toxicology — Posted on 2025-03-11
4034 Lit-OTAR Framework for Extracting Biological Evidences from Literature
Tirunagari, S.; Saha, S.; Venkatesan, A.; Suveges, D.; Buniello, A.; Ochoa, D.; McEntyre, J.; McDonagh, E.; Harrison, M.
10.1101/2024.03.06.583722 — bioinformatics — Posted on 2025-03-11
4037 Improved nucleoside (2'-deoxy)ribosyltransferases maximize enzyme promiscuity while maintaining catalytic efficiency
Tang, P.; Zickuhr, G. M.; Dickson,, A. L.; Harding, C. J.; Devi, S.; Lebl, T.; Harrison,, D. J.; da Silva, R. G.; Czekster, C. M.
10.1101/2025.03.05.641663 — biochemistry — Posted on 2025-03-11
4038 Bayesian analysis and efficient algorithms for single-molecule fluorescence data and step counting
Mattamira, C.; Ward, A.; Krishnan, S. T.; Lamichhane, R.; Barrera, F. N.; Sgouralis, I.
10.1101/2025.03.04.641510 — biochemistry — Posted on 2025-03-11
4041 Season-specific responses of freshwater ciliate communities to top-down and bottom-up experimental manipulations
Asghar, U.; Mukherjee, I.; Sonntag, B.; Pires de Paula, C. C.; Kasalicky, V.; Bulzu, P.-A.; Singh, A. P.; Shabarova, T.; Piwosz, K.; Simek, K.
10.1101/2025.03.06.641887 — ecology — Posted on 2025-03-11
4042 TET dioxygenases localize at splicing speckles and promote RNA splicing
Hastert, F. D.; Weber, J.; Bauer, C.; Zhadan, A.; Singh, D. N.; Dix, T. C.; Arnold, R.; Bessonov, S.; Soller, M.; Leonhardt, H.; Cardoso, M. C.; Arroyo, M.
10.1101/2025.03.07.641893 — cell biology — Posted on 2025-03-11
4045 The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells
Delgado, M.-G.; Burkhart, A.-K.; Villar, J.; Amadio, R.; Racz, V. S.; Sanseau, D.; De Silva, N.; Lacerda Mariano, L.; Bracchetti, G.; Shmakova, A.; Chipont, A.; San Roman, M.; Calmettes, V.; Alraies, Z.; Maurin, M.; Dauphin, A.; Guerin, C.; Ginhaux, F.; Manel, N.; Fachinetti, D.; Benvenuti, F.; Iden, S.; Lennon-Dumenil, A.-M.
10.1101/2024.12.27.630538 — cell biology — Posted on 2025-03-11
4046 Unpacking bedaquiline hetero-resistance: the importance of intermediate profiles for phenotypic drug-susceptibility testing
Ismail, N.; Sirgel, F.; Omar, S. V.; Omar, S.; de Kock, M.; Spies, C.; Folkerts, M.; Theron, G.; Engelthaler, D. M.; Metcalfe, J. Z.; Warren, R. M.
10.1101/2025.03.09.642295 — microbiology — Posted on 2025-03-11
4048 Pre-clinical studies of Schistosoma mansoni vaccines: a scoping review
Houlder, E. L.; Ferreira da Silva, L.; van Diepen, A.; Amaral, M. S.; Wilson, R. A.; Hokke, C. H.; Roestenberg, M.; Bakker, W. A. M.
10.1101/2025.03.03.641165 — immunology — Posted on 2025-03-11
4049 Two-Stage CD8+ CAR T-Cell Differentiation in Patients with Large B-Cell Lymphoma
Cao, G.; Hu, Y.; Pan, T.; Tang, E.; Asby, N.; Althaus, T.; Wan, J.; Riedell, P.; Bishop, M.; Kline, J.; Huang, J.
10.1101/2025.03.05.641715 — immunology — Posted on 2025-03-11
4051 openretina: Collaborative Retina Modelling Across Datasets and Species
D'Agostino, F.; Zenkel, T.; Gonschorek, D.; Höfling, L.; Euler, T.; Bethge, M.
10.1101/2025.03.07.642012 — neuroscience — Posted on 2025-03-11
4052 A genetic signature of resistance to activity-based anorexia in striatal projecting cortical neurons
Huang, K.; Magateshvaren Saras, M. A.; Conn, K.; Greaves, E.; Reed, F.; Tyagi, S.; Munguba, H.; Foldi, C. J.
10.1101/2025.03.09.642272 — neuroscience — Posted on 2025-03-11
4053 Using a female-specific isoform of doublesex to explore male-specific hearing in mosquitoes
Su, M. P.; Georgiades, M.; Andres, M.; Somers, J.; Bagi, J.; Loh, Y. M.; Xu, Y. Y.; Kyrou, K.; Crisanti, A.; Albert, J. T.
10.1101/2025.03.09.642281 — neuroscience — Posted on 2025-03-11
4055 Development of Potent, Selective cPLA2 Inhibitors for Targeting Neuroinflammation in Alzheimer's Disease and Other Neurodegenerative Disorders
Sadybekov, A. V.; Duro, M. V.; Wang, S.; Ebright, B.; Dikeman, D.; Hugo, C.; Kerman, B. E.; Ma, Q.-L.; Nazarova, A. L.; Sadybekov, A. A.; Asante, I.; Louie, S. G.; Katritch, V.; Yassine, H. N.
10.1101/2025.03.09.641748 — neuroscience — Posted on 2025-03-11
4056 Molecular and cellular signatures differentiate Parkinson's disease from Parkinson's disease with dementia
Fairbrother-Browne, A.; Grant-Peters, M.; Brenton, J. W.; Nelvagal, H.; Reynolds, R. H.; Lim, Y. M.; Gustavsson, E. K.; Macpherson, H.; Montgomery, K.; Evans, J. R.; Hicks, A. R.; Chiraki, N.; Curless, T.; Real, R.; Xenakis, T.; Houlden, H.; Morris, H. R.; Gandhi, S.; Wood, N. W.; Hardy, J.; Jaunmuktane, Z.; Ryten, M.
10.1101/2025.03.04.641379 — neuroscience — Posted on 2025-03-11
4057 Motivational Cognitive Maps for Self-Regulated Autonomous Navigation
Guerrero Rosado, O.; Amil, A. F.; Freire, I. T.; Vinck, M.; Verschure, P. F. M. J.
10.1101/2025.03.10.642337 — neuroscience — Posted on 2025-03-11
4058 Spike sorting biases and information loss in a detailed cortical model
Laquitaine, S.; Imbeni, M.; Tharayil, J.; Isbister, J. B.; Reimann, M. W.
10.1101/2024.12.04.626805 — neuroscience — Posted on 2025-03-11
4062 High-Resolution Time-Lapse Imaging of Droplet-Cell Dynamics via Optimal Transport and Contrastive Learning
Schlotheuber, L. J.; Vollenweider, M.; Gutjahr, S.; Hungerland, T.; Danis, R.; Ormaniec, W.; Linder, A.; Boeva, V.; Lüchtefeld, I.; Eyer, K.
10.1101/2025.03.06.641128 — bioinformatics — Posted on 2025-03-10
4067 Adaptive feedforward speed control in Drosophila
Campbell, B. P.; Supple, J. A.; Fabian, S. T.; Lin, H.-T.; Krapp, H. G.
10.1101/2025.03.03.641162 — bioengineering — Posted on 2025-03-10
4069 Trifluoroacetate reduces plasma lipid levels and the development of atherosclerosis in mice
Tang, W.; Black, A. S.; Moench, R.; Marzban, K.; Raygoza Garay, J. A.; Zheng, J. J.; Conway, L.; Pinto, A. F. M.; Parker, C. G.; Saghatelian, A.; Leman, L. J.; Ghadiri, M. R.
10.1101/2025.03.06.641713 — biochemistry — Posted on 2025-03-10
4070 From Plasmid to Pure Protein: Production and Characterization of SARS-CoV-2 PLpro
De Falco, A.; Greene-Cramer, R.; Shurina, B. A.; Zakian, S.; Acton, T. B.; Ramelot, T. A.; Montelione, G. T.
10.1101/2025.03.09.642282 — biochemistry — Posted on 2025-03-11
4072 Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts
Nishioka, K.; Ikezaki, M.; Iwahashi, N.; Arakawa, M.; Fukushima, M.; Mori, N.; Mizoguchi, M.; Horiuchi-Tanizaki, Y.; Fujino, M.; Tomiyama, T.; Ihara, Y.; Uchimura, K.; Ino, K.; Nishitsuji, K.
10.1101/2025.03.06.641957 — biochemistry — Posted on 2025-03-11
4073 Protein massively parallel binding assay reveals transcription factor binding determinants
Lupo, O.; Brodsky, S.; Jana Lang, T.; Manadre, W.; Valinsky, G.; Navon, Y.; Mindel, V.; Barkai, N.
10.1101/2025.03.05.641616 — genomics — Posted on 2025-03-11
4076 Deciphering the metabolic details of L-lysine toxicity in cyanobacteria
Enkerlin, A. M.; Hoffmann, U. A.; Rapp, J.; Miao, R.; Link, H.; Hudson, E. P.; Selim, K. A.
10.1101/2025.03.10.642250 — microbiology — Posted on 2025-03-10
4077 Microbiome functional gene pathways predict cognitive performance in older adults with Alzheimers disease
Zeamer, A. L.; Lai, Y.; Sanborn, V.; Loew, E.; Tracy, M. S.; Jo, C.; Ward, D.; Bhattarai, S. K.; Drake, J. D.; McCormick, B. A.; Bucci, V.; Haran, J. P.
10.1101/2025.03.06.641911 — microbiology — Posted on 2025-03-11
4078 A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights
Cha, J. H.; Kim, N.; Ma, J.; Lee, S.; Koh, G.; Yang, S.; Beck, S.; Byeon, I.; Lee, B.; Lee, I.
10.1101/2025.03.10.642329 — microbiology — Posted on 2025-03-11
4079 DNA-PKcs governs LAT-dependent signaling in CD4+ and CD8+ T cells
Rainwater, R. R.; Azevedo-Pouly, A.; Waldrip, Z.; Hicks, B. H.; Callais, N. A.; Koss, B.; Storey, A. J.; Burdine, L.; Burdine, M.
10.1101/2025.03.06.641745 — immunology — Posted on 2025-03-10
4083 Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling
Li, H.; Cieslak, M.; Salo, T.; Shinohara, R. T.; Oathes, D. J.; Davatzikos, C.; Satterthwaite, T. D.; Fan, Y.
10.1101/2025.03.09.642155 — neuroscience — Posted on 2025-03-10
4087 Chlamydomonas chloroplast genes tolerate compression of the genetic code to just 51 codons
Mordaka, P. M.; Clouston, K.; Cui, J.; Holzer, A.; Jackson, H. O.; Purton, S.; Smith, A. G.
10.1101/2025.03.09.641718 — synthetic biology — Posted on 2025-03-10
4088 Human Stress Response Specificity through Bioresonance Selectivity
Worcester, M.; Nejad, S.; O'Donnell, D.; Arian, S.; Mishra, P.; Naeini, A. E.; Li, S.; Yang, K.; Anbir, A.; Guevara, M.; Yuan, N. Y.; O'Leary, S.; Kaul, M.; Zandi, R.; Kuhlman, T. E.
10.1101/2025.03.05.641735 — biophysics — Posted on 2025-03-10
4091 zAMP and zAMPExplorer: Reproducible Scalable Amplicon-based Metagenomics Analysis and Visualization
Scherz, V.; Nassirnia, S.; Chaabane, F.; Szekely, V. C.; Greub, G.; Pillonel, T.; Bertelli, C.
10.1101/2025.03.09.633768 — bioinformatics — Posted on 2025-03-10
4097 Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression
Menard, R.; Morin, E.; Morse, D.; Halluin, C.; Pende, M.; Baanannou, A.; Grendler, J.; Fuqua, H.; Li, J.; Lancelot, L.; Drent, J.; Bonnet, F.; Graber, J. H.; Murawala, P.; Dray, C.; Pradere, J.-P.; Coffman, J. A.; Madelaine, R.
10.1101/2025.03.07.642048 — developmental biology — Posted on 2025-03-10
4098 Quantification of H3.1-nucleosomes using a chemiluminescent immunoassay: a reliable method for neutrophil extracellular trap detection
Wargnies, M.; Rommelaere, G.; Candiracci, J.; Pamart, D.; Varsebroucq, R.; Jibassia, F.; Serneo, F.; Laloux, V.; Thiry, O.; Lambert, F.; Lobbens, A.; Van den Ackerveken, P.; Herzog, M.
10.1101/2025.03.05.641629 — molecular biology — Posted on 2025-03-10
4099 PRMT activity promotes global 3' UTR shortening in proliferating cells
Griffith, L.; Capitanchik, C.; Moore, S.; Farcas, A.; Gwynne, M.; Pedna, M.; Jones, D. M.; Chakrabarti, A. M.; Lagos, D.; Urosevic, J.; Lynch, J. T.; Ule, J.
10.1101/2025.03.06.641848 — molecular biology — Posted on 2025-03-10
4100 A genome-wide ATLAS of liver chromatin architecture reveals that sex dictates diet-induced nucleosome dynamics
ZHANG, Z.; Su, V.; Wiese, C. B.; Cheng, L.; Wang, D.; Cui, Y.; Kallapur, A.; Kim, J.; Wu, X.; Tran, P. H.; Zhou, Z.; Casero, D.; Li, W.; Hevener, A. L.; Reue, K.; Sallam, T.
10.1101/2024.11.13.623052 — molecular biology — Posted on 2025-03-10
4101 Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa
Huang, J.; Sun, Y.; Chen, F.; Li, S.; Han, L.; Li, J.; He, Z.; Hua, C.; Yao, C.; Li, T.; Lu, B.; Chang, Y.-F.; Deng, X.
10.1101/2024.10.14.618254 — microbiology — Posted on 2025-03-10
4102 Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum
Richards, D.; Sohn, K.; Basavarajappa, S. C.; Horowitz, D.; Rusbuldt, J.; Tomsho, L.; Paget, K.; Chavez, I.; Van den Berge, K.; McRae, B.; Loughnane, H.; Hussey, S.; Walsh, P.; Ruane, D.
10.1101/2025.03.05.641653 — immunology — Posted on 2025-03-10
4106 Proteomic characterization of the Alzheimer's disease risk factor BIN1 interactome
Mcmillan, J.; Wang, S.; Wohlfahrt, J.; Guergues, J.; Stevens, S.; Thinakaran, G.
10.1101/2025.03.09.642169 — neuroscience — Posted on 2025-03-10
4108 Application of machine learning to discriminate photoreceptor cell species in xenotransplanted chimeric retinas
Li, K. V.; Pan, A.; Liu, Y. V.; Antonio-Aguirre, B.; Wang, J.; Adams, M.; McNerney, C.; Tun, S. B. B.; Jimenez, K.; Lu, Y.; Li, Z.; McNally, M.; Barathi, V. A.; Johnston, R. J.; Singh, M. S.
10.1101/2025.03.09.642229 — neuroscience — Posted on 2025-03-10
4109 Targeting glial PD-1/PD-L1 restores microglial homeostasis and attenuates neuronal hyperactivity in Alzheimer's disease model
Park, T.; Chang, L.; Chung, S. W.; Lee, S.; Bae, S.; Condello, C.; Kim, Y. H.; Lee, J.; Kim, H.-J.; Kwon, H.-K.; Suh, M.
10.1101/2024.09.13.612389 — neuroscience — Posted on 2025-03-10
4112 Transcriptomic Analysis of CAD Cell Differentiation
Cevallos, C. A.; White, A. L.; Fazio, B. A.; Wendt, L. S.; Feng, J. W.; Posfai, D.; Horton, A. L.; Warrick, J. M.; Quintero-Carmona, O. A.
10.1101/2025.03.09.642086 — neuroscience — Posted on 2025-03-10
4114 IL-7-mediated expansion of autologous lymphocytes increases CD8+ T Cell VLA-4 expression and accumulation within glioblastoma
Singh, K.; Hotchkiss, K. M.; Cook, S. L.; Noldner, P.; Zhou, Y.; Moelker, E. M.; Railton, C. O.; Blandford, E. E.; Puviindran, B. J.; Wallace, S. E.; Norberg, P. K.; Archer, G. E.; Shaz, B.; Ayasoufi, K.; Sampson, J. H.; Khasraw, M.; Fecci, P. E.
10.1101/2024.04.01.587634 — cancer biology — Posted on 2025-03-10
4117 VESNA: An Open-Source Tool for Automated 3D Vessel Segmentation and Network Analysis
Schüttler, M.; Dogan, L.; Kirchner, J.; Ergün, S.; Wörsdörfer, P.; Fischer, S.
10.1101/2025.03.05.641600 — bioinformatics — Posted on 2025-03-10
4121 Aortic annuloplasty FSI digital twin of 3D-printed phantoms with 4D-flow MRI comparison
Bontempi, L.; Zattoni, M.; Ramella, A.; Migliavacca, F.; Ringgaard, S.; Kim, W. Y.; Johansen, P.; Colombo, M.
10.1101/2025.03.05.641637 — bioengineering — Posted on 2025-03-10
4123 Targeted suppression of type 1 interferon signaling during RNA delivery enhances vaccine-elicited immunity
Kim, B. J.; Hosn, R. R.; Remba, T. K.; Dye, J.; Mak, H. H.; Jeong, J. Y.; Cornwall-Brady, M.; Abraham, W.; Maiorino, L.; Melo, M. B.; Li, B.; Zhang, Y.; Dong, Y.; Irvine, D. J.
10.1101/2025.03.09.642244 — bioengineering — Posted on 2025-03-10
4124 Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma
Li, K.; Tolman, N.; Segre, A. V.; Stuart, K. V.; Zeleznik, O. A.; Vallabh, N. A.; Hu, K.; Zebardast, N.; Hanyuda, A.; Raita, Y.; Montgomery, C.; Zhang, C.; Hysi, P. G.; Do, R.; Khawaja, A. P.; Wiggs, J. L.; Kang, J. H.; John, S. W.; Pasquale, L. R.
10.1101/2025.01.18.633745 — genomics — Posted on 2025-03-10
4126 Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
Forey, R.; Pulver, C.; Raclot, C.; Rosspopoff, O.; Offner, S.; Duc, J.; Planet, E.; Martins, F.; Turelli, P.
10.1101/2025.03.05.641617 — genetics — Posted on 2025-03-10
4128 An innovative approach in identifying a network of priority wetland sites in the East Asian-Australasian Flyway for a new sustainable management investment programme
Crosby, M.; Wee, S. Q. W.; Yong, D. L.; Allport, G.; Chowdhury, S.; Gan, X.; Hagemeijer, W.; Jensen, A. E.; Lang, D.; Layusa, C.; Lee, Y.; Mundkur, T.; Oh, H.; Shi, J.; Townsend, T.; Watkins, D.; Zeng, Q.; Balint, L.; Barchiesi, S.; Bhargava, R.; Fairburn, W.; Friess, D. A.; Pina-Covarrubias, E.; Ochavo, K. G. C.; Tang, H.; Peh, K. S.- H.
10.1101/2025.03.05.641701 — ecology — Posted on 2025-03-10
4129 Optimizing microbial intake helps to maintain the gut microbiome diversity
Marquioni, V. M.; Hofacker, A.-C.; Villavicencio, J. V.; Bansept, F.
10.1101/2025.03.05.641598 — ecology — Posted on 2025-03-10
4132 Bovine Formative Embryonic Stem Cell Plasticity in Embryonic and Extraembryonic Differentiation
Su, Y.; Zhao, R.; Fang, Y.; Li, G.; Jin, L.; Liu, J.; Yang, Z.; Li, N.; Zhu, J.; Mishra, N.; Kaback, D.; Yee, S.-P.; Lei, C.; Duan, E.; Tian, X.; Tang, Y.
10.1101/2024.12.28.630627 — developmental biology — Posted on 2025-03-10
4135 Structural Insights into Cir-mediated Killing by the Antimicrobial Protein Microcin V
Maurakis, S. A.; O'Donnell, A. C.; Botos, I.; Ghirlando, R.; Davies, B. W.; Buchanan, S. K.
10.1101/2025.03.06.641670 — molecular biology — Posted on 2025-03-10
4136 RNA-triggered fluorescence controlled by RNA switches for real-time RNA expression tracking in living plants
Bai, J.; Chen, Y.; Zhang, J.; Li, J.; Ren, H.; Pan, S.; Tao, Y.; Lei, M.; Dong, M.; Liu, S.; Yi, J.; Chen, F.; Fan, C.; Zhao, Y.
10.1101/2025.03.03.641157 — molecular biology — Posted on 2025-03-10
4137 A cell atlas of human and mouse synovium from early and advanced stages of knee osteoarthritis: BHLHE40 regulates fibroblast activation
Thavaratnam, K.; Gracey, E.; Ratneswaran, A.; Rockel, J. S.; Vohra, S.; Pastrello, C.; Stappers, F.; Planckaert, G.; Hueniken, K.; Garcia, J.; Kaur, P.; Lively, S. S.; Potla, P.; Vlieghe, C.; Rampersaud, Y. R.; Mahomed, N. N.; Victor, J.; Arnout, N.; Jurisica, I.; Gandhi, R.; Elewaut, D.; Kapoor, M.
10.1101/2025.03.05.641539 — molecular biology — Posted on 2025-03-10
4138 Reduced intestinal GLP-1+ cell numbers are associated with an inflammation-related epithelial metabolic signature
Urbauer, E.; Aguanno, D.; Kuellmer, K.; Metwaly, A.; Waldschmitt, N.; Ahmed, M.; Khaloian, S.; Hoermannsperger, G.; Planchais, J.; Fromme, T.; Sartor, R. B.; Sokol, H.; Haller, D.; Rath, E.
10.1101/2025.03.05.641577 — molecular biology — Posted on 2025-03-10
4139 The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in Mycobacterium abscessus
Alam, M. S.; Khatun, M. S.; Yusuf, B.; Li, L.; Belachew, A. M.; Tadesse, H. A.; Zhang, J.; Tian, X.; Fang, C.; Gao, Y.; Liu, Z.; Hameed, H. M. A.; Hu, J.; Chen, X.; Zhong, N.; Wang, S.; Zhang, T.
10.1101/2025.03.04.641476 — molecular biology — Posted on 2025-03-10
4142 CD8+ T cells drive myofibroblast activation and contraction via JAK/STAT3 and TGFβ signaling
Papadimitriou, T. I.; van Essen, A.; Willemse, M.; Dorst, D. N.; Vitters, E.; Walgreen, B.; Koenen, H. J. P. M.; van der Kraan, P.; Koenders, M.; Thurlings, R. M.; van Caam, A.
10.1101/2025.03.05.641635 — immunology — Posted on 2025-03-10
4143 Role of IL10 signaling in the circadian control of host response to Influenza infection
Forrest, K.; Towers, M.; Paul, O.; Cho, H.; Padmini, M. V.; Naik, A.; Lim, h. K.; Issah, Y.; Deshmukh, H.; Abt, M. C.; Hudock, K.; Grant, G. R.; Brooks, T. G.; Sengupta, S.
10.1101/2025.03.03.641134 — immunology — Posted on 2025-03-10
4148 Maternal separation disrupts noradrenergic control of adult coping behaviors
Vazquez, C. R.; Becker, L. J.; Kuo, C.-C.; Cariello, S. A.; Hamdan, A. N.; Al-Hasani, R.; Maloney, S. E.; McCall, J. G.
10.1101/2025.03.09.642152 — neuroscience — Posted on 2025-03-10
4152 Phytoliths to apPROXYmate Maya landscapes over early Anthropocene : case of Naachtun tropical wetland.
TESTE, M.; CASTANET, C.; GARNIER, A.; LIMONDIN-LOZOUET, N.; PURDUE, L.; LEMONNIER, E.; KERDREUX, S.; NONDEDEO, P.
10.1101/2025.03.05.641636 — paleontology — Posted on 2025-03-10
4153 Investigation of the heterogeneity of cancer cells using single cell calcium profiling.
Bura, A.; Caussette, C.; Gueguinou, M.; Bellanger, D.; Robert, A.; Cancel, M.; Lacouette-Rata, M.; Fromont-Hankard, G.; Vandier, C.; Maheo, K.; Brouard, T.; Crottes, D.
10.1101/2024.01.14.575608 — cancer biology — Posted on 2025-03-10
4154 The slit diaphragm in Drosophila features a bi-layered, fishnet-like architecture
Moser, D.; Lang, K.; Birtasu, A. N.; Scheffer, M. P.; Helmstaedter, M.; Hermle, T.; Frangakis, A. S.
10.1101/2025.03.06.641875 — biophysics — Posted on 2025-03-10
4155 SVelfie: A method for discovering cancer drivers based on enrichment of likely functional structural variants
Loinaz, X.; Dagan, J.; Alberge, J.-B.; Kowalewski, A.; Miller, M.; Hess, J. M.; Rheinbay, E.; Stewart, C.; Getz, G.
10.1101/2025.03.09.642284 — bioinformatics — Posted on 2025-03-10
4158 Designer DX-tile DNAns hydrogels
Scarton, D. V.; Coogan, A. B.; Tulun, E. O.; Harrison, K. A.; Touma, P. M.; Buchen, J.; Steiner, R. C.; Fellin, C. R.; Mason, H. G.; Hu, C.-H.; Yuan, X.; Jariwala, S.; Veneziano, R.
10.1101/2025.03.05.641269 — bioengineering — Posted on 2025-03-10
4159 Methionine sulfoxide reductase B3 antioxidant activity is indispensable for mouse inner ear cuticular plate structure and hair bundle integrity
Nayak, G.; Richard, E.; Lee, B. C.; Riordan, G. P.; Belyantseva, I. A.; Manta, B.; Friedman, T. B.; Gladyshev, V. N.; Riazuddin, S.
10.1101/2025.03.04.641487 — genetics — Posted on 2025-03-10
4160 Mapping-based genome size estimation
Natarajan, S.; Gehrke, J.; Pucker, B.
10.1101/607390 — genomics — Posted on 2025-03-10
4161 Who is who in necromass formation and stabilization in soil? Unraveling the role of fungi and bacteria as complementary players of biogeochemical functioning
Lepori, S.; Rohner, N.; Li, X.; Feng, X.; Wagai, R.; Loaiza, V.; Sebag, D.; Verrecchia, E.; Nelson, D. B.; Kahmen, A.; Chenu, C.; Niklaus, P. A.-; Laine, A.-L.; Domeignoz-Horta, L. A.
10.1101/2025.03.06.641408 — ecology — Posted on 2025-03-10
4165 Redox control of antibiotic biosynthesis
Devine, R.; Noble, K.; Stevenson, C.; Martins, C.; Saalbach, G.; McDonald, H. P.; Hems, E. S.; Wilkinson, B.; Hutchings, M. I.
10.1101/2025.03.04.641395 — molecular biology — Posted on 2025-03-10
4167 Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30
Izumikawa, K.; Shida, T.; Onodera, Y.; Tashima, Y.; Miyao, S.; Suda, T.; Suda, Y.; Sugihara, M.; Nogichi, T.; Nagahama, M.
10.1101/2025.03.04.641417 — molecular biology — Posted on 2025-03-10
4169 Targeted BDNF upregulation via upstream open reading frame disruption
Feng, N.; Goedert, T.; Svrzikapa, N.; Yan, D.; Hanson, B.; Ljungdahl, A.; Dafinca, R.; Talbot, K.; Sanders, S. J.; Gupta, D.; Wood, M.; Roberts, T. C.
10.1101/2025.03.04.641482 — molecular biology — Posted on 2025-03-10
4170 Identification of a unique TUBB3+ cell population in the tuberculosis granuloma
Monard, S.; Metais, A.; Pingret, M.; Buscail, C.; Caouaille, M.; Faucher, M.; Mazeres, S.; Poincloux, R.; Rombouts, Y.; Klein, B. S.; Wuethrich, M.; Salguero, F. J.; Clark, S. O.; Montagutelli, X.; Simon-Loriere, E.; Molina, J.-M.; De Castro, N.; Gaudenzio, N.; Vashakidze, S.; Magnon, C.; Vilaplana, C.; Lugo-Villarino, G.; Verollet, C.; Neyrolles, O.
10.1101/2025.03.04.641465 — immunology — Posted on 2025-03-10
4171 Hock immunization: a refined alternative for developing Experimental Autoimmune Myasthenia Gravis (EAMG) in mice.
Mane-Damas, M.; Schöttler, A. K.; Mohile, T.; Arets, B.; Tüzün, E.; Losen, M.; Martinez Martinez, P.
10.1101/2025.03.06.640628 — immunology — Posted on 2025-03-10
4174 Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In vitro
Suklai, P.; Minckley, T. F.; Hagemann, C.; Faber, K.; Norkett, R.; Guetta, L.; OToole, K.; Geary, B.; Devine, M. J.; Serio, A.
10.1101/2025.03.07.642064 — neuroscience — Posted on 2025-03-10
4176 Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency
Kasen, A.; Lovestam, S.; Breton, L.; Meyerdirk, L.; McPhail, J. A.; Piche, K.; Louwrier, A.; Capan, C. D.; Lee, H.; Scheres, S. H. W.; Henderson, M. X.
10.1101/2025.03.07.642026 — neuroscience — Posted on 2025-03-10
4178 Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area
Lei, H. C.; Parker, K. E.; Kuo, C.-C.; Yuede, C. M.; McCall, J. G.; Imai, S.-i.
10.1101/2023.01.19.524624 — neuroscience — Posted on 2025-03-10
4184 Experimental Autoimmune Encephalomyelitis Causes Skeletal Muscle Dysfunction in Mice
Boesch, J.; Ramseier, P.; Tisserand, S.; Pierrel, E.; Locatelli, G.; Summermatter, S.
10.1101/2025.03.04.641397 — physiology — Posted on 2025-03-10
4186 LRP2 is a potential molecular target for pathological myopia
Delaunay, K.; Picard, E.; Lassiaz, P.; Jonet, L.; Cannaya, V.; Ruiz Moreno, J. M.; Kojima, K.; Vorum, H.; Honore, B.; Medrano, J. R.; Cehofski, L. J.; Pussard, E.; Kozyraki, R.; Torriglia, A.; CASES, O.; Behar-Cohen, F.
10.1101/2025.03.04.641381 — pathology — Posted on 2025-03-10
4189 Development of three-color FRET measurement of force-dependent sensing of RIAM-Vinculin interactions in focal adhesions
Treacy, C. A.; Pallett, T. L.; Bui, T. T.; Poland, S. P.; Pfuhl, M. A.; Parsons, M.; Ameer-Beg, s. M.
10.1101/2025.03.04.641466 — biophysics — Posted on 2025-03-10
4191 Searching for influencers among placental immune cells in preeclampsia.
Paik, H.; Ko, T. L.; Sirota, M.; Park, J.-E.; Bunis, D.; Lee, S.-K.; Heo, H.
10.1101/2025.03.04.641363 — bioinformatics — Posted on 2025-03-10
4197 OncoProExp: An Interactive Shiny Web Application for Comprehensive Cancer Proteomics and Phosphoproteomics Analysis
Sharif Rahmani, E.; Lingasamy, P.; Khojand, S.; Lawarde, A.; Vela Moreno, S.; Salumets, A.; Modhukur, V.
10.1101/2025.03.06.641407 — bioinformatics — Posted on 2025-03-10
4198 SOX7: Novel Autistic Gene Identified by Analysis of Multi-Omics Data
Gonzales, S.; Zhao, J. Z.; Choi, N. Y.; Acharya, P.; Jeong, S.; Wang, X.; Lee, M.-Y.
10.1101/2023.05.26.542456 — bioinformatics — Posted on 2025-03-10
4199 Biofabrication of an in situ hypoxia-delivery scaffold for cartilage regeneration
Di Gesu', R.; Palumbo Piccionello, A.; Vitale, G.; Buscemi, S.; Panzavolta, S.; Di Filippo, M. F.; Leonarda, A.; Cuccia, M.; Di Prima, A.; Gottardi, R.
10.1101/2025.03.04.641405 — bioengineering — Posted on 2025-03-10
4200 Nicotinamide-loaded Peptoid Nanotubes for Energy Regeneration in Acute Brain Injury
Du, H.; Trinh, H.; Brandon, O. C.; Zheng, R.; Wang, H.; Corry, K.; Wood, T. R.; Chen, C.-L.; Nance, E.
10.1101/2025.03.06.641448 — bioengineering — Posted on 2025-03-10
4203 Profile of proteins involved in iron homeostasis and energy metabolism in multiple organs of leptin-deficient mice
Ferreira, A. P. O.; Pino, J. M. V.; da Luz, M. H. M.; de Souza, G. O.; Junior, J. D.; Lee, K. S.
10.1101/2025.03.04.641404 — biochemistry — Posted on 2025-03-10
4204 Structural basis for the RC-LH1 supercomplex of Dinoroseobacter shibae for anaerobic anoxygenic photosynthesis
Wang, P.; Liu, Z.-K.; Li, J.-X.; Zhang, Y.-Y.; Lv, J.-L.; Li, K.; Chen, X.-L.; Liu, L.-N.; Zhang, Y.-Z.
10.1101/2025.03.03.641346 — biochemistry — Posted on 2025-03-10
4205 The genomic landscape of spider monkeys and northern muriquis from a conservation perspective
Hermosilla-Albala, N.; Palmada-Flores, M.; Gomez-Garrido, J.; Silva, F. E.; Alentorn-Moron, P.; Faella, A.; Martinez, S.; Fernandez-Bellon, H.; Almagro, V.; Messias, M.; Kaizer, M. C.; Farias, I.; Hrbek, T.; da Silva, M. N. F.; Mendoza, A. P.; Vilchez-Delgado, F.; Shanee, S.; de Souza Silva Junior, J.; Rossi, R.; Valsecchi, J.; Mayor, P.; Hvilsom, C.; Lizano, E.; Alioto, T. S.; Gut, M.; Gut, I. G.; Kuderna, L. F.; Rogers, J.; Farh, K. K.-H.; Marques-Bonet, T.; Boubli, J. P.
10.1101/2025.03.07.641388 — genomics — Posted on 2025-03-10
4206 Early warning signals of emerging infectious diseases
Zhao, Q.; Moniz, N.; Korotasz, A.; Barbera, C.; Rohr, J. R.
10.1101/2025.03.03.641350 — ecology — Posted on 2025-03-10
4207 Aphid colony size is affected by plant chemotype and terpenoid mixture evenness in tansy
Neuhaus-Harr, A.; Ojeda-Prieto, L.; Zhang, X.; Schnitzler, J.-P.; Weisser, W. W.; Heinen, R.
10.1101/2025.03.04.641370 — ecology — Posted on 2025-03-10
4208 A staged approach using ants as test organism in ecotoxicology
Pohl, M.; Otto, M.; Hommen, U.; Eilebrecht, S.; Schaefers, C.; Ringbeck, B.; Goeckener, B.; Gadau, J.
10.1101/2025.03.04.641392 — ecology — Posted on 2025-03-10
4211 Genomic and morphological characterisation of a novel iridovirus, bivalve iridovirus 1 (BiIV1), infecting the common cockle (Cerastoderma edule)
Hooper, C.; Tidy, A. M.; Jessop, R.; Bateman, K. S.; Green, M. J.; Ross, S. H.; Ward, G. M.; Hazelgrove, R.; Hunt, J. E.; Parker, M.; Bass, D.
10.1101/2025.03.05.641634 — molecular biology — Posted on 2025-03-10
4212 Single-cell profiling of blood and cerebrospinal fluid in tuberculous meningitis
Tram, T. T. B.; Garner, L. C.; Thai, L. N. H.; Nhat, L. T. H.; Thu, D. D. A.; Nghia, H. D. T.; Van, L. H.; Thwaites, G. E.; Ha, V. T. N.; Klenerman, P.; Thuong, N. T. T.
10.1101/2025.03.04.641394 — immunology — Posted on 2025-03-10
4213 Dynamic Causal Tractography Analysis of Auditory Descriptive Naming:An Intracranial Study of 106 Patients
Kanno, A.; Kochi, R.; Sakakura, K.; Kitazawa, Y.; Uda, H.; Ueda, R.; Sonoda, M.; Lee, M.-H.; Jeong, J.-W.; Rothermel, R.; Luat, A. F.; Asano, E.
10.1101/2025.03.07.641428 — neuroscience — Posted on 2025-03-10
4214 Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders
Ellegood, J.; Beauchamp, A.; Yee, Y.; Devenyi, G.; Ziolkowski, J.; Qiu, L.; Askalan, R.; Ayub, M.; Suetterlin, P.; Donovan, A.; Basson, M. A.; Quesnel, K. M.; Berube, N. G.; Woo, T.; Beversdorf, D.; Bjornsson, H.; Blakely, R.; Crawley, J.; Crosbie, J.; Orr, B. O.; Davis, G. W.; Genestine, M.; DiCicco-Bloom, E.; Egan, S.; Fink, K. D.; Asbury, S.; Lai, J.; Rilett, K.; Foster, J. A.; Vincent, J. B.; Frankland, P.; Georgiades, S.; Penagarikano, O.; Geschwind, D.; Giger, R. J.; Markx, S.; Gogos, J.; Golzio, C.; Pagani, M.; Gozzi, A.; Pacey, L. K.; Hampson, D.; Huang, T.-N.; Yen, T.-L.; Hsueh, Y.-P.
10.1101/2025.03.04.641443 — neuroscience — Posted on 2025-03-10
4215 Global brain maintenance predicts well-preserved cognitive function: A pooled analysis of three longitudinal population-based Swedish cohorts
Korkki, S.; Narbutas, J.; Salami, A.; Ryden, L.; Kalpouzos, G.; Andersson, M.; Kern, S.; Skoog, J.; Westman, E.; Skoog, I.; Rizzuto, D.; Nyberg, L.
10.1101/2025.03.04.641447 — neuroscience — Posted on 2025-03-10
4216 Transformations of the spatial activity manifold convey aversive information in CA3
Miguel-Lopez, A.; Nikbakht, N.; Wert-Carvajal, C.; Gschossmann, L.; Pofahl, M.; Beck, H.; Tchumatchenko, T.
10.1101/2025.03.04.641439 — neuroscience — Posted on 2025-03-10
4217 Neural Synchrony Links Sensorimotor Cortices in a Network for Facial Motor Control
Vazquez, Y.; Ianni, G. R.; Rassi, E.; Rouse, A. G.; Schieber, M.; Yazdani, F.; Prut, Y.; Freiwald, W.
10.1101/2025.03.04.641458 — neuroscience — Posted on 2025-03-10
4219 Pregnenolone and AEF0117 block cannabinoid-induced hyperlocomotion through GSK3β signaling at striatopallidal neurons
Tomaselli, G.; Bellocchio, L.; Raux, P.-L.; Roullot-Lacarriere, V.; Busquets-Garcia, A.; Lalanne, V.; Mariani, Y.; Cathala, A.; Zanese, M.; Cannich, A.; Grel, A.; Gisquet, D.; Mondesir, M.; Metna-Laurent, M.; Drutel, G.; Marsicano, G.; Piazza, P.-V.; Revest, J.-M.; Vallee, M.
10.1101/2025.03.07.641990 — neuroscience — Posted on 2025-03-10
4222 Formation of Task Representations and Replay in Mouse Medial Prefrontal Cortex
Shabani, H.; Muysers, H.; Yiu, Y.-H.; Sauer, J.-F.; Bartos, M.; Leibold, C.
10.1101/2025.03.07.642001 — neuroscience — Posted on 2025-03-10
4227 PIA SSN: Parallel Image Acquisition and Spatial Similarity Network for Tandem Mass Spectrometry Imaging
Sharma, V. V.; Toth, G.; Lillja, J.; Martinis, R.; Hansen, C. E.; Kooij, G.; Lanekoff, I.
10.1101/2025.03.07.642022 — neuroscience — Posted on 2025-03-10
4231 Independent Continuous Tracking of Multiple Agents in the Human Hippocampus
Chericoni, A.; Fine, J. M.; Chavez, A. G.; Franch, M.; Mickiewicz, E.; Mathura, R.; Adkinson, J.; Bartoli, E.; Jacobs, J.; Provenza, N.; Watrous, A.; Yoo, S. B. M.; Sheth, S.; Hayden, B. Y.
10.1101/2025.03.06.641914 — neuroscience — Posted on 2025-03-10
4232 Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation
Danhash, E. P.; Verbeck, A. C.; Western, D.; Diaz-Pacheco, A.; Galasso, G.; You, S.-F.; Nadarajah, C. J.; Tiemann-Powles, S.; Huang, G.; Musiek, E. S.; Herz, J.; Iyer, A. K.; Cirrito, J.; Cruchaga, C.; Karch, C. M.
10.1101/2025.03.06.641917 — neuroscience — Posted on 2025-03-10
4233 High Incidence of Estrous Cycle Irregularities in Heterogeneous Stock (HS) Rats is Associated with Severe Cocaine Addiction-like Behaviors
Sneddon, E. A.; Chonwattanagul, S.; Bai, K.; Kurup, P. H.; Plasil, S. L.; Doyle, M. R.; Zahedi, S.; Simpson, S.; Sichel, B. C.; Othman, D. N.; Brennan, M.; Palmer, A. A.; Kallupi, M.; Carrette, L. L. G.; de Guglielmo, G.; George, O.
10.1101/2025.03.06.641918 — neuroscience — Posted on 2025-03-10
4234 A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy
Carlini, M. J.; Espinoza-Derout, J.; Van Alstyne, M.; Tisdale, S.; Workman, E.; Triplett, M.; Tattoli, I.; Yadav, S.; Henderson, C.; Watterson, M. D.; Pellizzoni, L.
10.1101/2025.03.06.641938 — neuroscience — Posted on 2025-03-10
4235 Advancing image-based meta-analysis for fMRI: A framework for leveraging NeuroVault data
Peraza, J. A.; Kent, J. D.; Blair, R. W.; Poline, J.-B.; Nichols, T. E.; de la Vega, A.; Laird, A. R.
10.1101/2025.03.06.641922 — neuroscience — Posted on 2025-03-10
4236 Females versus males exhibit greater brain activation in sensorimotor regions during motor imagery after stroke
Klick, S. M.; Magnuson, J. R.; Rubino, C.; Rajendran, A.; Denyer, R.; Jones, C. B.; Brocato, J.; Lamb, C.; Schaurich, C.; Koren, T.; Boyd, L. A.; Kraeutner, S. N.
10.1101/2025.03.06.641936 — neuroscience — Posted on 2025-03-10
4239 FACED 2.0 enables large-scale voltage and calcium imaging in vivo
Zhong, J.; Natan, R. G.; Zhang, Q.; Wong, J. S. J.; Miehl, C.; Bose, K.; Lu, X.; St-Pierre, F.; Guo, S.; Doiron, B.; Tsia, K. K.; Ji, N.
10.1101/2025.03.06.641784 — neuroscience — Posted on 2025-03-10
4240 TLR4+ Dermal fibroblasts induce acute and transitional pain states
Lenert, M. E.; Agalave, N. M.; Debner, E. K.; Tierney, J. A.; Naqvi, S. A.; Chavez, A. M.; Dockum, M.; Albrecht, P.; Rice, F. L.; Price, T. J.; Sanchez, E. L.; Burton, M. D.
10.1101/2025.03.07.641865 — neuroscience — Posted on 2025-03-10
4241 The impact of intrinsic connectome dynamics on perception is context-dependent
Mostame, P.; Hesselmann, G.; Bido-Medina, R.; Kleinschmidt, A.; Sadaghiani, S.
10.1101/2025.03.06.641785 — neuroscience — Posted on 2025-03-10
4243 High-throughput 3D super-resolution imaging in deep tissue
Du, Z.; Chen, J.; Gao, C.; Li, J.; Ru, Q.; Zheng, Y.; Gong, W.; Si, K.
10.1101/2025.03.07.641978 — neuroscience — Posted on 2025-03-10
4249 CABaNe, an automated, high content ImageJ macro for cell and neurite analysis
Thibieroz, N.; Cordelieres, F.; Lopes Cardoso Filho, J.-C.; Machillot, P.; Marchadier, L.; Singh, A.; Picart, C.; Migliorini, E.
10.1101/2025.03.07.641590 — neuroscience — Posted on 2025-03-10
4250 Refining the adjuvant-induced rat model of monoarthritis by optimizing the induction volume and injection site
Berke, M. S.; Hansen, C. P.; Kromann, S.; Colding-Jorgensen, P.; Kalliokoski, O.; Jensen, H. E.; Sorensen, D. B.; Hau, J.; Abelson, K. S. P.; Hestehave, S.
10.1101/2025.03.06.641822 — neuroscience — Posted on 2025-03-10
4252 Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus
Berry, J. E.; Jimenez, J.; Chang, W.-l.; Ogbu, K. M.; Manfred, N.; Tegang, K.; Fusi, S.; Hen, R.; Lacefield, C.
10.1101/2025.03.07.641976 — neuroscience — Posted on 2025-03-10
4254 Altered cortical network in Parkinson's Disease: the central role of PV interneuron and synaptic remodelling
Minetti, A.; Montagni, E.; Meneghetti, N.; Macchi, F.; Coulomb, E.; Martello, A.; Tiberi, A.; Capsoni, S.; Mazzoni, A.; Allegra Mascaro, A. L.; Spalletti, C.
10.1101/2025.03.05.641628 — neuroscience — Posted on 2025-03-10
4255 Protective ApoE variants support neuronal function by extracting peroxidated lipids
Ralhan, I.; Do, A. D.; Bae, J.-Y.; Feringa, F. M.; Cai, W.; Chang, J.; Chik, K.; Lee, N. Y. J.; Gerry, C.; van der Kant, R.; Jackson, J.; Ricq, E. L.; Ioannou, M. S.
10.1101/2025.03.05.641722 — neuroscience — Posted on 2025-03-10
4257 Disrupted white matter microstructure in chronic Zika virus-infected adults
Jun, S.; Bido-Medina, R. O.; Oviedo, J.; Miches, I.; Llano, D.; Tusen, L.; Stoeter, P.; Rodriguez, M.; Sadaghiani, S.
10.1101/2025.03.05.641727 — neuroscience — Posted on 2025-03-10
4258 SpIC3D imaging: Spinal In-situ Contrast 3D imaging
Liang, L.; Fasse, A.; Damiani, A.; Jantz, M.; Agbor, U.; Del Brocco, M.; Monney, R.; Rowland, C.; Newton, T. H.; Gopinath, C.; Schaeffer, D. J.; Kolarcik, C. L.; Fisher, L. E.; Neufeld, E.; Capogrosso, M.; Gaunt, R. A.; Hitchens, T. K.; Pirondini, E.
10.1101/2025.03.05.641747 — neuroscience — Posted on 2025-03-10
4259 Parabrachial bombesin receptor subtype 3 neurons facilitate heat pain in persistent inflammation
Allen, H. N.; Nelson, T. S.; Dufeal, N. A.; Grabus, N. K.; Trevett, K.; Merrett, J.; Khanna, R.
10.1101/2025.03.05.641630 — neuroscience — Posted on 2025-03-10
4261 GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration
Paillard, T.; Allam, A.; Doulazmi, M.; Hautefeuille, M.; Fouquet, C.; Sarde, L.; Stoufflet, J.; Spassky, N.; Nedelec, S.; Dusart, I.; Trembleau, A.; Caille, I.
10.1101/2025.03.05.641658 — neuroscience — Posted on 2025-03-10
4262 Two-timepoint assays of neural responses increase the sensitivity and specificity of single-cell whole-brain activity screens
Ramirez, A.; Rogerson, L.; Kyzar, E. J.; Berland, C.; Rodriguez, E.; Guerrero, J.; Hammond, L.; Ferrante, A. W.; Salzman, C. D.
10.1101/2025.03.07.641687 — neuroscience — Posted on 2025-03-10
4263 Amyloid-beta pathology increases synaptic engulfment by glia in feline cognitive dysfunction syndrome: A naturally occurring model of Alzheimer's disease
McGeachan, R. I.; Ewbank, L.; Watt, M.; Sordo, L.; Malbon, A.; Salamat, M. K. F.; Tzioras, M.; De Frias, J. M.; Tulloch, J.; Houston, F.; Gunn-Moore, D.; Spires-Jones, T. L.
10.1101/2025.03.06.641819 — neuroscience — Posted on 2025-03-10
4264 GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
Sturman, O.; Schmutz, M.; Lorimer, T.; Zhang, R.; Privitera, M.; Roessler, F. K.; Leonardi, J. T.; Waag, R.; Marinescu, A.-M.; Bekemeier, C.; Hohlbaum, K.; Bohacek, J.
10.1101/2025.03.07.642046 — neuroscience — Posted on 2025-03-10
4266 Genetic and Circuit Mechanisms Underlying Natural Variation in Value-Based Decision Making
Motevalli, D.; Alfredson, R.; Fogleman, S.; Medrano, E.; Silander, W. I.; Hige, T.; Dickson, B. J.; Stern, U.; Yang, R. C.-H.
10.1101/2025.03.07.641729 — neuroscience — Posted on 2025-03-10
4270 Morphogenesis and morphometry of brain folding patterns across species
Yin, S.; Liu, C.; Choi, G. P. T.; Jung, Y.; Heuer, K.; Toro, R.; Mahadevan, L.
10.1101/2025.03.05.641692 — neuroscience — Posted on 2025-03-10
4272 Exercise induces anti-inflammatory reprogramming in macrophages via Hsp60
Chatzigeorgiou, A.; Moustogiannis, A.; Christopoulos, P.; Vlachogiannis, N. I.; Michopoulos, F.; Verrou, K.-M.; Papadopoulos, G.; Velliou, R.-I.; Giannousi, E.; Mitroulis, I.; Chmelar, J.; Theodossiou, T. A.; Samiotaki, M.; Philippou, A.; Sfikakis, P. P.; Koutsilieris, M.
10.1101/2025.03.03.640779 — physiology — Posted on 2025-03-10
4273 Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity
Bose, M. R.; Sears, J. D.; Talbot, K. M.; Su, Y.-W. N.; Houliston, S.; Hossain, M. A.; Davis-Gilbert, Z. W.; Zhao, C.; Oh, H. J.; Brown, P. J.; Sanders, M. K.; Moorman, S. R.; Ojha, D.; Burdick, J. E.; Law, I.; Morales, N. L.; Martinez, S. A.; Loppnau, P.; Perez, J. G.; Drobish, A. M.; Morrison, T. E.; Streblow, Z. J.; Streblow, D. N.; Arrowsmith, C. H.; Vargason, A.; Counago, R. M.; Halabelian, L.; Arnold, J. J.; Cameron, C. E.; Moorman, N. J.; Heise, M. T.; Willson, T. M.
10.1101/2025.03.04.641060 — pharmacology and toxicology — Posted on 2025-03-10
4277 Mapping human cerebral blood flow with high-density, multi-channel speckle contrast optical spectroscopy
Kim, B.; Howard, A. C.; Cheng, T. Y.; Anderson, J. E.; Zimmermann, B.; Hazen, E.; Carlton, L.; Robinson, M.; Renna, M.; Yucel, M. A.; Carp, S.; Franceschini, M. A.; Boas, D. A.; Cheng, X.
10.1101/2025.03.03.638332 — bioengineering — Posted on 2025-03-10
4278 Calibration and validation strategy for electromechanical cardiac digital twins
Wang, Z. J.; Holmes, M.; Doste, R.; Camps, J.; Margara, F.; Vazquez, M.; Rodriguez, B.
10.1101/2025.03.06.638897 — bioengineering — Posted on 2025-03-10
4279 In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Harvey, E. P.; Smith, J. S.; Hurley, J. D.; Granados, A.; Schmid, E. W.; Liang-Lin, J. G.; Paul, S.; Meara, E. M.; Ferguson, M. P.; Calvillo-Miranda, V. G.; Marks, D. S.; Walter, J. C.; Kruse, A. C.; Susa, K. J.
10.1101/2025.03.05.640882 — biochemistry — Posted on 2025-03-10
4281 Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders
Zhou, Z.; Luquette, L. J.; Dong, G.; Kim, J.; Ku, J.; Kim, K.; Bae, M.; Shao, D. D.; Sahile, B.; Miller, M. B.; Huang, A. Y.; Nathan, W. J.; Nussenzweig, A.; Park, P. J.; Lagier-Tourenne, C.; Lee, E. A.; Walsh, C. A.
10.1101/2025.03.03.641186 — genomics — Posted on 2025-03-10
4282 Non-canonical DNA in human and other ape telomere-to-telomere genomes
Smeds, L.; Kamali, K.; Kejnovska, I.; Kejnovsky, E.; Chiaromonte, F.; Makova, K. D.
10.1101/2024.09.02.610891 — genomics — Posted on 2025-03-10
4284 Genomes reveal age and demographic consequence of ultrafast adaptive radiation
Marques, D. A.; Meier, J. I.; McGee, M. D.; Haesler, M. P.; Mwaiko, S.; Kishe, M. A.; Taabu-Munyaho, A.; Chapman, L.; Chapman, C. A.; Wandera, S. B.; Wagner, C. E.; Excoffier, L. E.; Seehausen, O.
10.1101/2025.03.07.638630 — evolutionary biology — Posted on 2025-03-10
4286 A glycan atlas of the mammalian intestine through ontogeny and inflammation
Siegel, S. J.; Pomerantz, D.; Heimburg-Molinaro, J.; Mahmood, S. D.; Korzenik, J. R.; Cummings, R. D.; Rakoff-Nahoum, S.
10.1101/2025.03.06.641959 — microbiology — Posted on 2025-03-10
4290 Towards Clinical Phage Microbiology for Biofilm Infections: A Comparative Study and a Suggested Protocol
Rimon, A.; Braunstein, R.; Yerushalmy, O.; Katz, N.; Yosef, L.; Gvili, Y.; Coppenhagen-Glazer, S.; Nir-Paz, R.; Hazan, R.
10.1101/2025.03.07.642007 — microbiology — Posted on 2025-03-10
4292 Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways
Miao, Y.; Yadav, V.; Shadrick, W.; Liu, J.; Jenner, A. R.; Gee, C.; Schäfer, M.; Perfect, J. R.; Lee, R. E.; Brennan, R. G.; Washington, E. J.
10.1101/2025.03.07.642065 — microbiology — Posted on 2025-03-10
4293 Macropinosomes are a site of HIV-1 entry into primary CD4+ T cells
Murakami, T.; de Souza Cardoso, R.; Manivannan, P.; Chang, Y.-T.; Rentchler, E.; Chou, K.-N.; Tang, Y.; Swanson, J. A.; King, P. D.; Ono, A.
10.1101/2025.03.07.642068 — microbiology — Posted on 2025-03-10
4295 Analysis of tracrRNAs reveals subgroup V2 of type V-K CAST systems
Ziemann, M.; Mitrofanov, A.; Stoeckl, R.; Alkhnbashi, O. S.; Backofen, R.; Hess, W. R.
10.1101/2025.03.07.641588 — microbiology — Posted on 2025-03-10
4297 Environmental drivers of the resistome across the Baltic Sea
Serrana, J. M.; Nascimento, F. J. A.; Dessirier, B.; Broman, E.; Posselt, M.
10.1101/2025.03.06.641941 — microbiology — Posted on 2025-03-10
4299 TL1A overexpression in Crohn's Disease and mice alters Paneth cells and microbiota promoting ileal inflammation
Ye, Y.; More, S.; Hamade, H.; Alexeev, E.; Shimodaira, Y.; Blackwood, A.; Stamps, D.; Miller, J.; Abraham, J.; Thomas, L.; Castanon, S.; Estrada, H.; Kumagai, K.; Potdar, A.; Haritunians, T.; Mengesha, E.; Wawrowsky, K.; Bhute, S.; Blumberg, R.; McGovern, D.; Sartor, B.; Shih, D.; Barrett, R.; Jacob, N.; Jacobs, J.; Targan, S.; Michelsen, K.
10.1101/2025.03.02.641061 — immunology — Posted on 2025-03-10
4301 Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses
Howlader, M. J.; Ambler, W. G.; Chalasani, M. L. S.; Rathod, A.; Seltzer, E.; Sim, J.; Shin, J.; Schwartz, N.; Shipman, W. D.; Dasoveanu, D.; Carballo, C.; Sevim, E.; Siddique, S.; Chinenov, Y.; Rodeo, S.; Erkan, D.; Kataru, R. P.; Mehrara, B.; Lu, T. T.
10.1101/2022.06.13.495930 — immunology — Posted on 2025-03-10
4302 Chaotic dynamics for homeostatic hematopoiesis
Jia, D.; Cavazos, E. S.; West, T.; Liang, S.-H.; Costa, R.; Salomon, M. C.; Huang, A.; Trinchieri, G.; Lionakis, M.; Mukherjee, R.; Altan-Bonnet, G.
10.1101/2024.08.16.608266 — immunology — Posted on 2025-03-10
4304 ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation
Sohn, H.; Kolicheski, A.; Laurent, J.; Tran, J.; Wang, Y.; Gan, K.; Tobin, J. M.; Saucier, N.; Fehniger, T. A.; Payton, J.; Cooper, M. A.
10.1101/2025.03.05.639198 — immunology — Posted on 2025-03-10
4305 Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence
Maynard, L. H.; Cavanaugh, E. J.; Zhu, H.; Starke, C. E.; Doherty, S. M.; Einhaus, T.; Perez, A.; Stensland, L.; Hoffman, M.; Nelson, V.; Herrin, S.; Littlewood, C.; Camou, K.; Wilson, E.; Wessel, C.; Jerome, K. R.; Kiem, H.-P.; Peterson, C. W.
10.1101/2025.03.05.640197 — immunology — Posted on 2025-03-10
4310 Intranasal Human NSC-derived EVs Therapy in Late Middle Age Can Restrain the Activation of NLRP3 Inflammasome and cGAS-STING Signaling in the Aged Hippocampus
Madhu, L. N.; Kodali, M.; Rao, S.; Attaluri, S.; Upadhya, R.; Shankar, G.; Shuai, B.; Somayaji, Y.; James, J. E.; Shetty, P.; Rao, X.; Shetty, A. K.
10.1101/2025.03.02.641082 — neuroscience — Posted on 2025-03-10
4312 Gradients of Recognition Molecules Wire Visuomotor Transformation
Dombrovski, M.; Zang, Y.; Frighetto, G.; Vaccari, A.; Jang, H.; Mirshahidi, P. S.; Xie, F.; Sanfilippo, P.; Hina, B. W.; Rehan, A.; Hussein, R. H.; Mirshahidi, P. S.; Lee, C.; Morris, A.; Frye, M. A.; von Reyn, C. R.; Kurmangaliyev, Y. Z.; Card, G. M.; Zipursky, S. L.
10.1101/2024.09.04.610846 — neuroscience — Posted on 2025-03-10
4313 Midbrain somatostatin-expressing cells control pain-suppression during defensive states
Winke, N.; Aby, F.; Jercog, D.; Bienvenu, T.; Riffault, C.; Bouali-Benazzouz, R.; Viellard, J.; Girard, D.; Grivet, Z.; Landry, M.; Castell, L.; Valjent, E.; Valerio, S.; Fossat, P.; Herry, C.
10.1101/2022.01.20.476899 — neuroscience — Posted on 2025-03-10
4314 Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice
Chou, S.-W.; Mortberg, M. A.; Marlen, K.; Ojala, D. S.; Parman, T.; Howard, M.; DeSouza-Lenz, K.; Lian, Y.; Mehrabian, M.; Tiffany, M.; Ledeboer, A.; Dunn, P.; Hu, J.; Guzman, K.; Kamath, N.; Cass, M.; Graffam, S.; Xu, L. M. H.; Laversenne, V.; Corridon, T. L.; Falcon, A.; Lew, G.; Sajuthi, S.; Zhang, L.; Cisbani, G.; Peters, F.; Fieblinger, T.; Melis, C.; Barenberg, J.; Hnatiuk, M.; Yu, Q.; Chung, D.; Jalan, M.; Hinkley, S.; Lu, Y.; Meyer, K.; Coffey, A.; Pooler, A. M.; Vallabh, S. M.; Minikel, E. V.; Zeitler, B.
10.1101/2025.03.05.636713 — neuroscience — Posted on 2025-03-10
4316 The Olfactory Epithelium: A Critical Gateway for Pathological Tau Propagation and a Target for Mitigating Tauopathy in the Central Nervous System
Dourte, M.; Paitre, E.; Bouchoucha, M.; Boyer, E.; Tome, S. O.; Doeraene, E.; Huart, C.; Leroy, K.; Thal, D. R.; Decottignies, A.; Hanseeuw, B.; Suelves, N.; Kienlen-Campard, P.
10.1101/2025.03.03.637437 — neuroscience — Posted on 2025-03-10
4317 Modulation statistics of natural soundscapes
Miller-Viacava, N.; Apoux, F.; Ferriere, R.; Friedman, N. R.; Mullet, T. C.; Sueur, J.; Willie, J.; Lorenzi, C.
10.1101/2025.03.04.638661 — neuroscience — Posted on 2025-03-10
4319 Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells
Bohrer, L. R.; Wiley, L. A.; Wright, A. T.; Hittle, B.; Affatigato, L. M.; Lang, M. J.; Powell, K. A.; Haefeli, L. M.; Han, I. C.; Mullins, R. F.; Stone, E. M.; Tucker, B. A.
10.1101/2025.03.04.640656 — neuroscience — Posted on 2025-03-10
4324 Role of channels in the O2 permeabilityof murine red blood cells. I. Stopped-flow and hematological studies
Zhao, P.; Moss, F. J.; Occhipinti, R.; Geyer, R. R.; Huffmann, D. E.; Meyerson, H. J.; Boron, W. F.
10.1101/2025.03.05.639948 — physiology — Posted on 2025-03-10
4325 Role of channels in the O2 permeability of murine red blood cells II. Morphological and proteomic studies
Moss, F. J.; Zhao, P.; Salameh, A. I.; Taki, S.; Wass, A. B.; Jacobberger, J. W.; Huffman, D. E.; Meyerson, H. J.; Occhipinti, R.; Boron, W. F.
10.1101/2025.03.05.639962 — physiology — Posted on 2025-03-10
4326 Identification of Rapaglutin E as An Isoform-specific Inhibitor of Glucose Transporter 1
Kotlyar, M.; Guo, Z.; Rao, A. V. S.; Peng, H.; Wang, J.; Ma, Z.; Schiene-Fischer, C.; Fischer, G.; Liu, J. O.
10.1101/2025.03.02.641094 — pharmacology and toxicology — Posted on 2025-03-10
4327 Aetokthonotoxin, the causative agent of vacuolar myelinopathy, uncouples oxidative phosphorylation due to protonophore activity
Rebhahn, V. I. C.; Saoud, M.; Winterhalter, M.; Schanbacher, F.; Jobst, M.; Ruiz, R.; Sonntag, A.; Kollatz, J.; Sprengel, R.; Donovan, S. F.; Del Favero, G.; Rennert, R.; Niedermeyer, T. H. J.
10.1101/2025.03.04.637646 — pharmacology and toxicology — Posted on 2025-03-10
4331 Activation of CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in animal models of alcoholic pancreatitis
Srinivasan, S.; Mehra, S.; Jinka, S.; Bianchi, A.; Singh, S.; Dosch, A. R.; Amirian, H.; Krishnamoorthy, V.; Silva, I. D. C.; Patel, M.; Box, E. W.; Garrido, V.; Totiger, T. M.; Zhou, Z.; Ban, Y.; Datta, J.; VanSaun, M.; Merchant, N.; Nagathihalli, N.
10.1101/2024.01.05.574376 — cancer biology — Posted on 2025-03-10
4333 Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy
Perdikari, A.; Woods, V. A.; Ebrahim, A.; Lawler, K.; Bounds, R.; Singh, N. I.; Mehlman, T.; Riley, B. T.; Sharma, S.; Morris, J. W.; Keogh, J. M.; Henning, E.; Smith, M.; Farooqi, I. S.; Keedy, D. A.
10.1101/2024.08.05.603709 — biophysics — Posted on 2025-03-10
4335 Differential effects of immobilized CCL21 and ICAM1 on TILs with distinct expansion properties
Yado, S.; Zoabi, R.; Brezinger-Dayan, K.; Albeck, S.; Unger, T.; Meiron, M.; Nahmad, A. D.; Gilat, A. T.; Besser, M. J.; Geiger, B.
10.1101/2025.03.02.641030 — bioengineering — Posted on 2025-03-10
4336 Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction
Wang, W.; Han, Z.; Aafreen, S.; Zivko, C.; Gololobova, O.; Wei, Z.; Cotin, G.; Felder-Flesch, D.; Mahairaki, V.; Witwer, K. W.; Bulte, J. W. M.; Weiss, R. G.; Liu, G.
10.1101/2025.03.02.641040 — bioengineering — Posted on 2025-03-10
4337 Hydroxychloroquine-functionalized Ionizable Lipids Mitigate Inflammatory Responses in mRNA Therapeutics
Chen, K.; Li, X.; Feng, S.; Li, Y.; Jiang, T.; Liu, Y.; Guo, N.; Zeng, X.; Yao, H.; Qiu, M.; Lu, J.; Lin, J.
10.1101/2025.03.02.641033 — bioengineering — Posted on 2025-03-10
4340 Small Molecule Modulators of TOX protein to Re-invigorate T cell Activity
Wu, B.; Chang, H. J.; Singh, P.; Hostetler, A.; Xiang, Y.; Guo, S.; Wang, F. Y.; Zhong, J. J.; Leifer, B. S.; Schiavoni, R. P.; Choudhary, A.; Westcott, P. M. K.; Koehler, A. N.
10.1101/2025.03.03.641115 — biochemistry — Posted on 2025-03-10
4341 Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins
Zimmermann, J.; Lang, L.; Malo Pueyo, J.; Reidel, M.; Wahni, K.; Stobbe, D.; Lux, C.; Janvier, S.; Vertommen, D.; Lenhard, S.; Hannemann, F.; Castro, H.; Tomas, A. M.; Herrmann, J.; Salvador, A.; Muehlhaus, T.; Riemer, J.; Messens, J.; Deponte, M.; Morgan, B.
10.1101/2025.03.03.641172 — biochemistry — Posted on 2025-03-10
4342 Resolution of collapsed forks is separate from completion of DNA synthesis
Conwell, S. C.; Dahmen, S. N.; Cranford, M. T.; Mulvaney, R. J.; Long, D. T.; Cortez, D.; Dewar, J. M.
10.1101/2025.03.03.641087 — biochemistry — Posted on 2025-03-10
4343 Combined Raman Microscopy and Transmission Electron Microscopy shows the co-existence of whitlockite crystals and carbonated hydroxyapatite-mineralized collagen fibrils in human calcified aortic valves
van der Meijden, R. H. M.; Kuster, C.; van Broekhoven, A.; Allgayer, R.; Rutten, L.; Roverts, R.; Cerruti, M.; Macias-Sanchez, E.; Cornel, J. H.; Sommerdijk, N.; El Messaoudi, S.; Akiva, A.
10.1101/2025.03.03.641198 — biochemistry — Posted on 2025-03-10
4347 Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival
Erdem, A.; Kaye, S.; Caligiore, F.; Johanns, M.; Leguay, F.; Schuringa, J. J.; Ito, K.; Bommer, G.; van Gastel, N.
10.1101/2025.03.03.641255 — cancer biology — Posted on 2025-03-07
4348 The characteristic of epithelial-specific phenotypes and immunosuppressive microenvironment in the context of tumour budding in colorectal cancer
Hatthakarnkul, P.; Fisher, N.; SchubertSantana, L.; Leslie, H.; Legrini, A.; Ammar, A.; Matly, A.; Pennel, K.; Powley, I.; Bull, C.; Alexander, P.; Sztanko, J.; Quinn, J.; Hay, J.; Morgan, H.; KennedyDietrich, C.; Doncheva, Y.; Lynch, G.; Maka, N.; Roxburgh, C.; Wyk, H. V.; Fu, X.; McMillan, D.; Dunne, P.; Jamieson, N.; Thuwajit, C.; Edwards, J.
10.1101/2025.03.05.641608 — cancer biology — Posted on 2025-03-07
4351 Identifying Antisense Oligonucleotides for Targeted Inhibition of Insulin Receptor Isoform A
Galifi, C. A.; Dikdan, R. J.; Kantak, D.; Bulatowicz, J. J.; Maingrette, K.; Gunderson, S. I.; Wood, T. L.
10.1101/2025.03.06.641707 — cancer biology — Posted on 2025-03-07
4352 DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes
Kaya, F.; Bewicke-Copley, F.; Miettinen, J. J.; Casado, P.; Leddy, E.; Deniz, O.; Lavallee, V.-P.; Philippe, C.; Zheng, J.; Grebien, F.; Khan, N.; Krizsan, S.; Saad, J.; Nolin-Lapalme, A.; Lemieux, S.; Audemard, E. O.; Matthews, J.; Grantham, M.; Di Bella, D.; Wennerberg, K.; Parsons, A.; Rio-Machin, A.; Gribben, J.; Cavenagh, J. D.; Freeman, S. D.; Bodor, C.; Sauvageau, G.; Wang, J.; Llamas-Sillero, P.; Cazier, J.-B.; Taussig, D. C.; Bonnet, D.; Cutillas, P. R.; Heckman, C.; Fitzgibbon, J.; Rouault-Pierre, K.
10.1101/2025.03.05.641116 — cancer biology — Posted on 2025-03-07
4353 A patient-derived ovarian cancer organoid platform to study susceptibility to natural killer cells
Mercadante, M.; Scheben, A.; Estrada, J.; Savas-Carstens, J.; Sullivan, W.; Housel, N.; Volpari, T.; Hebner, J.; Sapar, M.; Rusielewicz, T.; Monsma, F. J.; Semrau, S.; Wang, Y.; Martin, L. A.
10.1101/2025.03.06.641285 — cancer biology — Posted on 2025-03-07
4354 Automatic computational classification of bone marrow cells for B cell pediatric leukemia using UMAP
Nino-Lopez, A.; Martinez-Rubio, A.; Picon-Gonzalez, R.; Castillo Robleda, A.; Ramirez Orellana, M.; Chulian, S.; Rosa, M.
10.1101/2025.03.03.641130 — cancer biology — Posted on 2025-03-07
4355 Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer
Domnich, M.; Pylaeva, E.; Siakaeva, E.; Kabankova, N.; Bedzinska, A.; Sojka, D.; Zebrowska, A.; Gawin, M.; Soldierer, M.; Rist, M.; Fochtman, D.; Ozel, I.; Giebel, B.; Helfrich, I.; Thiel, I.; Thakur, B. K.; Kuerten, C. H. L.; Hanenberg, H.; Lang, S.; Ludwig, S.; Pietrowska, M.; Jablonska, J.
10.1101/2025.03.06.641593 — cancer biology — Posted on 2025-03-07
4357 Granulocyte Derived Resistin Inhibits Monocyte Maturation and Induces Immune Suppression in CMML
Hull, N. J.; Cant, R.; Guest, L. A.; Wang, Y.-H.; Gurashi, K.; Paredes, R.; Huerga Encabo, H.; Lin, C.-C.; Tien, H.-F.; Sellers, R.; Sahoo, S.; Bonnet, D.; Selimoglu-Buet, D.; Solary, E.; Wiseman, D. H.; Batta, K.
10.1101/2025.03.03.640303 — cancer biology — Posted on 2025-03-07
4358 Diverse transcriptomic and mutational patterns but limited functional pathway alterations in patient-derived SS cells
Gallardo, F.; Andrades, E.; Iglesias, A.; Maqueda, M.; Lobo, T.; Gonzalez, J.; Bertran, j.; Bellosillo, B.; Pujol, R. M.; Bigas, A.; Espinosa, L.
10.1101/2025.03.07.641995 — cancer biology — Posted on 2025-03-07
4359 Analysis of Head and Neck Cancer scRNA-seq Data Identified PRDM6 Promotes Tumor Progression by Modulating Immune Gene Expression
Wu, Z.; Lepcha, T. T.; Zhou, D.; He, Z.; Fiches, G. N.; Park, Y.; He, J.; Shanaka, K. A. S. N.; Oghumu, S.; Zhao, W.; Ma, A.; Ma, Q.; Zhu, J.; Santoso, N. G.
10.1101/2025.03.04.641548 — cancer biology — Posted on 2025-03-07
4360 A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Zimmerman, J.; Malone, B.; Finkin-Groner, E.; Sun, S.; Liang, R.; Foronda, M.; Schatoff, E.; Granowsky, E.; Goswami, S.; Katti, A.; Leach, B.; Alcorn, H.; Tammela, T.; Fukase, Y.; Khan, T.; Huggins, D.; Ginn, J.; Liverton, N.; Hite, R.; Dow, L.
10.1101/2025.03.04.641305 — cancer biology — Posted on 2025-03-07
4362 Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma
Liu, X.; Liu, Z.; Kobayashi, T.; Lei, P.-J.; Shi, Y.; Yuan, D.; Wang, J.; Li, M.; Matsui, A.; Mafra, K.; Huang, P.; Kuang, M.; Bod, L.; Duda, D. G.
10.1101/2025.03.04.641494 — cancer biology — Posted on 2025-03-07
4363 Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer
Boudhraa, Z.; Tian, X.; Ritch, S.; Gam, R.; Kendall-Dupont, J.; Carmona, E.; Provencher, D.; Wu, J. H.; Mes-Masson, A.-M.
10.1101/2025.03.02.641080 — cancer biology — Posted on 2025-03-07
4364 SPINK1-COL18A1 Crosstalk Shapes Epigenome and Drives Cancer Stemness in Pancreatic Ductal Adenocarcinoma
Tang, H.; Sailo, B.; Shang, X.; Das, P.; Chhoda, A.; Aldo, P.; Robert, M. E.; Kunstman, J.; Pappou, E.; Wood, L.; Iacobuzio-Donahue, C. A.; Hruban, R.; Wolfgang, C. L.; He, L.; Pfaff, M.; Ang-Olson, O.; Garcia-Milian, R.; Mazzetto, M.; Sharma, A.; Levchenko, A.; Ahuja, N.
10.1101/2025.03.03.641251 — cancer biology — Posted on 2025-03-07
4365 Thyroid Hormone Receptor Beta Signaling is a Targetable Driver of Prostate Cancer Growth
Fesiuk, A.; Pölöske, D.; de Araujo, E. D.; Frere, G. A.; Wright, T. B.; Tin, G.; Raouf, Y. S.; Olaoye, O. O.; Sung Park, J.; Schlederer, M.; Högler, S.; Philippe, C.; Neubauer, H.; Aksoy, O.; Varady, A.; Mata, A. M.; Varenicja, M.; Szabo, B.; Weiss, T.; Wasinger, G.; Redmer, T.; Susani, M.; Spielvogel, C.; Ning, J.; Dahlhoff, M.; Schepelman, M.; Kennedy, R.; Brown, G.; Persson, J.; Bystry, V.; Holloczki, O.; Heery, D. M.; Gunning, P. T.; Merkel, O.; Hantusch, B.; Kenner, L.
10.1101/2025.03.05.641137 — cancer biology — Posted on 2025-03-07
4366 Towards an armed oncolytic virus approach to glioblastoma treatment.
Calistri, A.; Reale, A.; Fornaini, M. V.; Donati, V.; De Oliveira Do Rego, A. G.; Panarelli, M.; Di Pietro, C.; Trevisan, M.; Persano, L.; Rampazzo, E.; Marazziti, D.; Mammano, F.
10.1101/2025.03.07.641877 — cancer biology — Posted on 2025-03-07
4368 Drug tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms
Davern, M.; Turner, C. J.; Bencsics, L.; Chan, B. C.; Kung, J. Y.-T.; Olson, M. L.; Williams, C. W.; Soni, S.; Krotee, L.; Yorsz, M.; Antonellis, G.; Lizotte, P. H.; Paweletz, C. P.; Ryan, J.; Birocchi, F.; Almazan, A. J.; Barbie, D.; Bhola, P.; Maus, M. V.; Letai, A.
10.1101/2025.03.04.641492 — cancer biology — Posted on 2025-03-07
4369 Relationship between melanoma vemurafenib tolerance thresholds and metabolic pathway choice and Wnt signaling involvement
Nangia-Makker, P.; Ahrens, M.; Purandare, N.; Aras, S.; Li, J.; Gurdziel, K.; Jang, H.; Kim, S.; Shekhar, M. P.
10.1101/2025.03.06.641924 — cancer biology — Posted on 2025-03-07
4370 The Th1/Th17 axis regulates chimeric antigen receptor (CAR) T cell therapy toxicities
Goala, P.; Zhang, Y.; Sailer, C.; McSain, S.; Tariq, M. J.; Hamid, S.; Gomez, E. C.; Wang, J.; Boucher, J. C.; Frontera, C. S.; Lee, S. B.; Kotani, H.; Jain, M.; Davila, M. L.
10.1101/2025.03.06.641668 — cancer biology — Posted on 2025-03-07
4372 Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22
Villemure, E.; Yauch, R. L.; Rudolph, J.; Januario, T.; Zeng, M.; Budayeva, H. G.; Walters, B. T.; Lictao, A.; Li, S. K.; Ye, X.; Gilchrist, C. L.; Hoag, B.; Endres, N. F.; Hsu, P. L.; Chan, J.; Cheung, T. K.; Costa, M. R.; Fortin, J.-P.; Ishisoko, N.; Babin, B. M.; Liu, J.
10.1101/2025.03.05.641484 — cancer biology — Posted on 2025-03-07
4373 Pan-cancer spatial characterization of key immune biomarkers in the tumor microenvironment
Lindsay, J. R.; Altreuter, J.; Alessi, J. V.; Weirather, J. L.; Giobbie-Hurder, A.; Dryg, I.; Hoebel, K.; Sharma, B.; Felt, K.; Hodi, F. S.; Lindeman, N.; Sholl, L. M.; Cerami, E.; Nowak, J. A.; Awad, M. M.; Rodig, S. J.; Lotter, W.
10.1101/2025.03.05.641733 — cancer biology — Posted on 2025-03-07
4374 Translating Genetics into Tissue: Inflammatory Cytokine-Producing TAMs and PD-L1 Tumor Expression as Poor Prognosis Factors in Cutaneous Melanoma
Barrio-Alonso, C.; Nieto-Valle, A.; Barandalla-Revilla, L.; Aviles-Izquierdo, J. A.; Parra-Blanco, V.; Sanchez-Mateos, P.; Samaniego, R.
10.1101/2025.03.04.640087 — cancer biology — Posted on 2025-03-07
4375 Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells
Woo, Q. Y.; Lau, P. K.; Lee, B. T. K.; Bajalovic, N.; Lee, S. H.; Leong, K. S.; Pow, K. Y.; Hanan, S.; Meng, W.; Lai, S. K.; Lin, V. C. L.
10.1101/2025.03.06.641096 — cancer biology — Posted on 2025-03-07
4377 Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models
Smer-Barreto, V.; Elliott, R. J. R.; Dawson, J. C.; Lorente-Macias, A.; Unciti-Broceta, A.; Oyarzun, D. A.; Carragher, N. O.
10.1101/2025.03.06.641926 — cancer biology — Posted on 2025-03-07
4379 Lysosomal membrane permeabilization enhances the anticancer effects of RNA Polymerase I transcription inhibitors
Ferret, L.; POL, J. G.; Sauvat, A.; Stoll, G.; Alvarez-Valadez, K.; Muller, A.; Le Naour, J.; Peyre, F.; Anagnostopoulos, G.; Martins, I.; Maiuri, M. C.; Wodrich, H.; Guittat, L.; Mergny, J.-L.; Kroemer, G.; Djavaheri-Mergny, M.
10.1101/2025.03.03.641132 — cancer biology — Posted on 2025-03-07
4381 Novel DNA endonuclease activity of human ERK1 protein
Ju, S.; Jeong, J.; Joo, B. C.; Lee, S. J.; Tarassov, S.; Chang, J. H.; Jeon, J. H.; Calderwood, S. K.; Lee, Y. U.; Bunch, H.
10.1101/2025.03.03.641133 — molecular biology — Posted on 2025-03-07
4382 Tumor hypoxia adaptation depends on FLAD1 mediated mitochondrial metabolic reprogramming
Zhao, X.; Wu, T.; Wu, S.; Chen, Y.; Zhang, Y.; Chen, J.; Diao, K.; He, Z.; Yan, J.; Lu, T.; Xu, C.; Liu, L.; Fan, G.; Xu, D.; Li, X.; Xiong, X.; Cheng, J.; Bai, F.; Liu, X.-S.
10.1101/2025.03.05.641576 — cancer biology — Posted on 2025-03-07
4383 Skuas mortalities linked to positives HPAIV A/H5 beyond Polar Antarctic Circle
Leon, f.; Ulloa, C.; Pizarro, E.; Castillo, P.; Diaz, K.; Claudia, A.; Timm, F.; Correa, M.; Kruger, L.; Poulin, E.; Pardo, C.; Vianna, J. A.
10.1101/2025.03.02.640960 — ecology — Posted on 2025-03-07
4385 The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes
Mehnert, A.-K.; Stegmaier, S.; Ramirez, C.; Magalhaes, V. G.; Siebenkotten, C.; Hu, J.; Costa, A. L.; Kirrmaier, D.; Knop, M.; Wu, X.; Tubiana, T.; Herrmann, C.; Binder, M.; Thi, V. L. D.
10.1101/2025.02.03.636239 — microbiology — Posted on 2025-03-07
4386 Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
Li, S.; Song, K.; Sun, H.; Tao, Y.; Huang, A.; Bhatia, V.; Hanratty, B.; Patel, R. A.; Long, H. W.; Morrissey, C.; Haffner, M. C.; Nelson, P. S.; Graeber, T. G.; Lee, J. K.
10.1101/2025.02.12.637904 — cancer biology — Posted on 2025-03-07
4392 Predictable Engineering of Signal-DependentCis-Regulatory Elements
Cornwall-Scoones, J.; Benzinger, D.; Yu, T.; Pezzotta, A.; Sagner, A.; Gerontogianni, L.; Bernadet, S.; Finnie, E.; Boezio, G. L. M.; Stuart, H. T.; Melchionda, M.; Inge, O. C. K.; Dumitrascu, B.; Briscoe, J.; Delas, M. J.
10.1101/2025.03.07.642002 — developmental biology — Posted on 2025-03-07
4394 Mechanical fracturing of the extracellular matrix patterns the vertebrate heart
Jin Ji, C. C.; Santos-Olivan, D.; Ramel, M.-C.; Sanchez-Posada, J.; Paizakis, P.; Andrews, T. G.; Noel, E. S.; Torres-Sanchez, A.; Priya, R.
10.1101/2025.03.07.641942 — developmental biology — Posted on 2025-03-07
4395 Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain
Dad, R.; Wang, Y.; Fang, C.; Chen, Y.; Zhang, Y.; Pan, X.; Zhang, X.; Swanekamp, E.; Patel, K.; Wolf, M. T. F.; Yuchi, Z.; Zhu, X.; Wu, H.-Y.
10.1101/2024.12.30.630763 — cell biology — Posted on 2025-03-07
4399 UHRF1 is critical for tumor-promoting inflammation and tumorigenesis in retinoblastoma
Gu, Y.; Suarez-Pizarro, M.; Chen, C. C.; Wu, J.; Zocchi, L.; Suh, S.; Smith, P. J.; Cruz, S. M.; Tinoco, R.; Benavente, C. A.
10.1101/2025.03.02.641083 — cancer biology — Posted on 2025-03-07
4404 Forward planning in a population-based alcohol use disorder sample
Steffen, J.; Fischbach, P. C.; Goenner, L.; Kiebel, S. J.; Smolka, M. N.
10.1101/2022.11.21.517329 — neuroscience — Posted on 2025-03-07
4405 TBCK-deficiency leads to compartment-specific mRNA and lysosomal trafficking defects in patient-derived neurons
Flores-Mendez, M.; Tintos-Hernandez, J. A.; Ramos-Rodriguez, L.; Miles, L.; Lo, T. Y.; Song, Y.; Ortiz-Gonzalez, X. R.
10.1101/2025.03.02.641041 — neuroscience — Posted on 2025-03-07
4406 Micromechanics of lung capillaries across mouse lifespan and in positive- vs negative-pressure ventilation
Regan, K.; Castle, L.; LeBourdais, R.; Kobayter, A.; Shi, L.; Wangsrikhun, W.; Grifno, G.; Banerji, R.; Batgidis, A.; Suki, B.; Nia, H. T.
10.1101/2025.03.02.641015 — physiology — Posted on 2025-03-07
4407 Aggregating gut: on the link between neurodegeneration and bacterial functional amyloids
Wojciechowska, A. W.; Wojciechowski, J. W.; Zielinska, K.; Soeding, J.; Kosciolek, T.; Kotulska, M.
10.1101/2024.11.26.624671 — bioinformatics — Posted on 2025-03-07
4409 A Rapid and Modular Nanobody Assay for Plug-and-Play Antigen Detection
Kang, N. R.; Biondo, J. R.; Sharpes, C. E.; Rhea, K. A.; Garden, P. M.; Jaramillo Montezco, J. J.; Ringaci, A.; Grinstaff, M. W.; Phillips, D. A.; Miklos, A. E.; Green, A. A.
10.1101/2025.03.01.640988 — bioengineering — Posted on 2025-03-07
4419 Spatial modelling improves genomic evaluation in Tanzanian smallholder admixed dairy cattle
Houaga, I.; Mrode, R.; Ojango, J.; Ekine-Dzivenu, C. C.; Okeyo, M.; Nziku, Z.; Nguluma, A.; Lavrencic, E.; Lindgren, F.; Pocrnic, I.; Djikeng, A.; Gorjanc, G.
10.1101/2025.03.01.640883 — genomics — Posted on 2025-03-07
4422 FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
Li, J. T.-Y.; Amiri, M.; Kailasam, S.; Sun, J.; Sonenberg, N.; Ortega, J.; Sossin, W. S.
10.1101/2025.02.21.639553 — neuroscience — Posted on 2025-03-07
4423 NADPH oxidase inhibitor enhances brain resilience in Alzheimer's disease by reducing tauopathy and neuroinflammation
Bae, Y. S.; Lee, J.; Sim, S.; Jin, Y.; Park, H.; Byeon, E. Y.; Kim, S. J.; Yun, S.; Lee, H. E.; Jeong, D. U.; Suh, J. M.; Lee, I. H.; Lee, H.-Y.; Choi, Y.
10.1101/2025.03.01.640956 — neuroscience — Posted on 2025-03-07
4429 Bacterial Vaginosis Toxins Impair Sperm Capacitation and Fertilization
Bhagwat, S. M.; Asadi, L.; McCarthy, R.; Ferreira, J.; Li, P.; Li, E.; Spivak, S.; Gaydon, A.; Reddy, V.; Armstrong, C.; Morrill, S. R.; Zhou, H.; Lewis, A. L.; Lewis, W. G.; Santi, C. M.
10.1101/2025.03.01.640991 — physiology — Posted on 2025-03-07
4432 Deciphering the molecular mechanisms of FET fusion oncoprotein-DNA hollow co-condensates
Zuo, L.; Guo, Q.; Zhang, K.; Jiang, B.; Chen, Z.; Xia, Y.; Qian, L.; Zhang, L.; Qi, Z.
10.1101/2025.03.01.641013 — biophysics — Posted on 2025-03-07
4433 Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy
Arifova, L.; MacTavish, B. S.; Laughlin, Z.; Karadi Girdhar, M. N.; Shang, J.; Li, M.-H.; Yu, X.; Zhu, D.; Kamenecka, T. M.; Kojetin, D. J.
10.1101/2025.03.04.640448 — biochemistry — Posted on 2025-03-07
4435 Distribution patterns of aquatic birds in a high-Andean wetland in southeastern Peru: an approach based on environmental factors
Lazo, C. A.; Diaz, R. D.; Diaz, A.; Bustinza, V.; Chavez, W.; Machaca, A. D.; Yarasca, Y.; Calderon, E.; Masias, M.
10.1101/2025.03.01.640977 — ecology — Posted on 2025-03-07
4437 Likely circulation of a coronavirus in roe deer (Capreolus capreolus) populations suggested by SARS-CoV-2 serological investigation in France
Perez, G.; Lalande, L. D.; Legros, V.; Kodjo, A.; Verheyden, H.; Bourret, V.; Cebe, N.; Chaval, Y.; Revelli, P.; Pellerin, M.; Lemaitre, J.-F.; Peroz, C.; Rey, B.; Debias, F.; Garcia, R.; Bourgoin, G.; Gilot-Fromont, E.
10.1101/2025.02.19.639030 — immunology — Posted on 2025-03-07
4438 ShenQi Compound improves diabetes by modulating pancreatic mitochondrial energy metabolism in GK rats
yuan, j.; zhang, h.; leng, y.; yuan, m.; liu, h.; Gao, H.; xie, h.; yuan, h.; xie, c.
10.1101/2025.03.01.640974 — zoology — Posted on 2025-03-07
4439 Intergenerational control of ribosomes under dietary restriction
Pradhan, S.; Stojanovski, K.; Tuomaala, J.; Stroustrup, N.; Towbin, B. D.
10.1101/2025.03.01.640961 — physiology — Posted on 2025-03-07
4440 CDK12/13 inhibition disrupts nucleolar morphology and promotes aberrant expression of IGS transcripts
Serafim, R. B.; Volegova, M.; Harlow, M.; Banerjee, U.; Cardoso, C.; Das, S.; Sharma, B.; Zentner, G. E.; Scacheri, P. C.; Zhang, T.; Gray, N. S.; Buratowski, S.; George, R. E.
10.1101/2025.03.01.640972 — cancer biology — Posted on 2025-03-07
4443 Dissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)
KANG, S.-U.; Park, J.; Ha, S.; Kim, D.; Pletnikova, O.; Redding, J.; Troncoso, J.; Peng, Q.; Emburgh, B.; Trivedi, J.; Brahmachari, S.; Nezami, B.; Dawson, V.; Dawson, T.
10.1101/2025.03.01.640894 — genomics — Posted on 2025-03-07
4444 Nuclear Calprotectin mediates Epithelial Wound Healing Defects in Crohns Disease related Fistula
Becker, M. A. J.; Koelink, P. J.; Ouahoud, S.; Meisner, S. M.; van Roest, M.; Muncan, V.; Frei, A. F.; Nabozny, G.; Li, F.; Saris, J.; Lartey, D. A.; Bemelman, W. A.; d'Haens, G. R.; Buskens, C. J.; Wildenberg, M. E.
10.1101/2025.03.06.641817 — cell biology — Posted on 2025-03-07
4447 Spatial transcriptomics elucidates the central role of cerebral vasculatures in the progression of Japanese encephalitis
Ou, Z.; Wang, Z.; Chen, Q.; Ren, P.; He, X.; Liang, Y.; Liang, Y.; Wang, J.; Liao, S.; Wang, D.; Zhao, J.; Zhang, O.; Peng, Z.; Su, J.; Li, W.; Hu, G.; Chen, A.; Deng, Z.; Jin, X.; Xu, X.; Li, J.; Cheng, G.
10.1101/2025.03.06.637776 — immunology — Posted on 2025-03-07
4448 Bodily perception links memory and self: a case study of an amnesic patient
Meyer, N. H.; Babo-Rebelo, M.; Potheegadoo, J.; Thanh, L. D. P.; Boscheron, J.; Herbelin, B.; Vuarnesson, L.; Stampacchia, S.; Toye, I. M.; Esposito, F.; Lacerda, M. M.; Trivier, A.; Beanato, E.; Alvarez, V.; Bassolino, M.; Blanke, O.
10.1101/2025.03.05.640721 — neuroscience — Posted on 2025-03-07
4450 Assessment of Genetic Resources to Major Tomato Diseases: Insights from wild germplasm and public S. lycopersicum collections
Hussain, E.; Cheng, C.-Y.; Huang, I.-M.; Lin, C.-y.; Gul, S.; Noorka, I. R.; Eybishitz, A.; Kanchana-udomkan, C.; van Zonneveld, M.; Lin, Y.-P.
10.1101/2025.03.04.641566 — plant biology — Posted on 2025-03-07
4451 Climate change and the thermal performance of a high protein food source: Wolffia globosa
Cuddington, K.; Kuntze, M.; Andrade-Pereira, D.; Gasmen, Y.; Wu, J.; Ferns, A.; Geng, X.
10.1101/2025.03.04.641473 — plant biology — Posted on 2025-03-07
4452 Powdery mildew exploits host plastoglobuli functions via DGAT3 and FBN2 for proliferation
Xue, H.; Kemmer, C. R.; Choi, E. H.; Iwai, M.; Niyogi, K. K.; Wildermuth, M. C.
10.1101/2025.03.04.641535 — plant biology — Posted on 2025-03-07
4455 MYB93 regulates responses to environmental sulphur in Arabidopsis and tomato.
Cao, X.; Wilkinson, H. B.; Hutton, B.; McMulkin, N.; Graham, N. S.; Etherington, R.; Oliver, A. G.; Clayton, C. M.; Kaur, H.; Coates, J. C.
10.1101/2025.03.04.641362 — plant biology — Posted on 2025-03-07
4457 Developmental regulators enable rapid and efficient soybean transformation and CRISPR-mediated genome editing
Alok, A.; Raman, V.; D Agostino, L.; Kshetry, A. O.; Rai, K. M.; Wang, C.; Gunapati, S.; Stupar, R. M.; Patil, G. B.; Zhang, F.
10.1101/2025.03.03.641322 — plant biology — Posted on 2025-03-07
4458 The hollow truth: ethylene-triggered ROS, PCD, senescence, and autophagy drive hollow stem formation
Yan, M.; Fan, W.; Yang, W.; Zhao, J.; Meng, Y.; Zhou, W.; Zhuang, H.; Xu, Z.; Wang, Y.; Huang, Q.; Yuan, L.; Wang, H.; Yang, J.
10.1101/2025.03.06.641815 — plant biology — Posted on 2025-03-07
4459 Heat stress negatively affects betalain biosynthesis in Amaranthus tricolor through down-regulation of CYP76AD1 and 5GT
Lin, Y.-P.; Ohokubo, T.; Nashiki, A.; Yoshioka, Y.; Zhang, Y.-Y.; Ting, H.-M.; Isobe, S.; Shirasawa, K.; Hoshikawa, K.
10.1101/2025.03.05.641739 — plant biology — Posted on 2025-03-07
4461 The Q-Warg Pipeline: A Robust and Versatile Workflow for Quantitative Analysis of Protoplast Culture Conditions
Bogdziewiez, L.; Froeling, R.; Schöppl, P.; Juquel, J.; Antoniadi, I.; Skalicky, V.; Mathey, A.; Fattaccioli, J.; Sprakel, J.; Verger, S.
10.1101/2025.03.05.641611 — plant biology — Posted on 2025-03-07
4463 Transcriptomic splicing analysis reveals a gene-independent form of TE reactivation in tumors representing unrecognized source of oncogenes and neoantigens
Li, Z.; Bao, Y.; Li, Q.; Yu, H.; Zhang, H.; Wen, Y.; Yang, Y.; Zhao, J.; Lin, P.; Li, Y.; Hu, Z.; Hu, X.; Zhu, X.; Huang, S.
10.1101/2025.03.01.640928 — cancer biology — Posted on 2025-03-07
4465 Peptide generative design with weakly order-dependent autoregressive language model and lifelong learning
Nie, Z.; Li, D.; Liu, Y.; Xu, F.; Zhang, H.; Huang, X.; Liu, X.; Wang, Z.; Ma, Y.; Ye, Y.; Yin, F.; Zhang, W.-B.; Ren, Z.; Liu, Z.; Li, Z.; Chen, J.
10.1101/2023.12.31.573750 — bioinformatics — Posted on 2025-03-07
4466 Protein stability prediction with dual-view ensemble learning from single sequence
Nie, Z.; Ma, Y.; Liu, Y.; Huang, X.; Liu, Z.; Yang, P.; Xu, F.; Yin, F.; Li, Z.; Fu, J.; Ren, Z.; Zhang, W.-B.; Chen, J.
10.1101/2024.04.22.590665 — bioinformatics — Posted on 2025-03-07
4467 DORA AI Scientist: Multi-agent Virtual Research Team for Scientific Exploration Discovery and Automated Report Generation
Naumov, V.; Zagirova, D.; Lin, S.; Xie, Y.; Gou, W.; Urban, A.; Tikhonova, N.; Alawi, K.; Durymanov, M.; Galkin, F.; Chen, S.; Sidorenko, D.; Korzinkin, M.; Scheibye-Knudsen, M.; Aspuru-Guzik, A.; Izumchenko, E.; Gennert, D.; Pun, F. W.; Zhang, M.; Kamya, P.; Aliper, A.; Ren, F.; Zhavoronkov, A.
10.1101/2025.03.06.641840 — bioinformatics — Posted on 2025-03-07
4468 Conserved strategies underpin the replicated evolution of aridity tolerance in trees
Halliwell, B.; Blackman, C. J.; Gallagher, R. V.; Yates, L. A.; Britton, T. G.; Jones, R. C.; Nicolle, D.; Hartill, G. E.; Wright, I. J.; Holland, B. R.; Brodribb, T. J.
10.1101/2025.03.06.641812 — evolutionary biology — Posted on 2025-03-07
4472 Rapid fluctuations in histamine associated with intake of nutritive and non-nutritive solutions
Volcko, K. L.; Gresch, A.; Benowitz, B.; Taghipourbibalan, H.; Visser, M.; Stuber, G. D.; Gordon-Fennell, A. G.; Patriarchi, T. E.; McCutcheon, J. E.
10.1101/2024.11.07.622425 — neuroscience — Posted on 2025-03-07
4473 Emergence of isochorismate-based salicylic acid biosynthesis within Brassicales
Hong, K.; Tang, Y.; Jeanguenin, L.; Kang, W.; Wang, Y.; Zuo, L.; Li, P.; He, J.; Jiang, W.; Huang, R.; Matsui, H.; Wang, Y.; Nakagami, H.; Li, B.; Li, X.; Xie, K.; Fukushima, K.; Guo, L.; Han, X.; Katagiri, F.; Hattori, M.; Tsuda, K.
10.1101/2025.03.03.641121 — plant biology — Posted on 2025-03-07
4475 Iron and zinc biofortification in potato through the introduction of NICOTIANAMINE SYNTHASE and FERRITIN genes
Cortelezzi, J. I.; Zubillaga, M.; Scardino, V. R.; Fumagalli, M.; Muniz Garcia, M. N.; Capiati, D. A.
10.1101/2025.03.01.640813 — plant biology — Posted on 2025-03-07
4476 Enhancing Plant Immune Training and Protection through Damage- and Microbe-Associated Molecular Patterns from Anaerobic Digestate
Greco, M.; Coculo, D.; Conti, A.; Abatematteo, M.; Agresti, S.; Pontiggia, D.; Melida, H.; Favaro, L.; Lionetti, V.
10.1101/2025.03.03.638737 — plant biology — Posted on 2025-03-07
4478 Plant cells tolerate high rates of organellar mistranslation
Brandt, B.; Schwartz, S.; Schwenkert, S.; Kraemer, M.; Om, K.; Engstler, C.; Klingl, A.; Jahns, P.; Eirich, J.; Finkemeier, I.; Cousins, A. B.; Kunz, H.-H.
10.1101/2025.03.07.642005 — plant biology — Posted on 2025-03-07
4479 New Insights into Plastocyanin-Cytochrome b6f Formation: the Role of Plastocyanin Phosphorylation
Milrad, Y.; Wegemann, D.; Kuhlgert, S.; Scholz, M.; Younas, M.; Vidal-Meireles, A.; Hippler, M.
10.1101/2025.03.07.641983 — plant biology — Posted on 2025-03-07
4480 The genome of the vining fern Lygodium microphyllum highlights genomic and functional differences between life phases of an invasive plant
Pelosi, J.; Davenport, R.; Kuo, L.-Y.; Gray, L. N.; Dant, A. J.; Kim, E. H.; Li, F.-W.; Dlugosch, K. M.; Krabbenhoft, T. J.; Barbazuk, W. B.; Sessa, E. B.
10.1101/2025.03.06.640867 — plant biology — Posted on 2025-03-07
4482 FX-Cell: a method for single-cell RNA sequencing on difficult-to-digest and cryopreserved plant samples
Ming, X.; Wan, M.-C.; Zhang, Z.-D.; Xue, H.-C.; Wu, Y.-Q.; Xu, G.-Z.; Mai, Y.-X.; Hu, Y.-X.; Liu, K.; Gao, J.; Shao, Q.-L.; Marchant, D. B.; Nelms, B.; Walbot, V.; Wang, J.-W.
10.1101/2025.03.04.641200 — plant biology — Posted on 2025-03-07
4484 Evolutionarily Conserved Heat-Induced Chromatin Dynamics Drive Heat Stress Responses in Plants
Wu, T.-Y.; Yen, M.-R.; Lin, K.-H.; Thalimaraw, L.; Yang, H.-R.; Boonyaves, K.; Cheng, C.-Y.
10.1101/2025.03.05.641738 — plant biology — Posted on 2025-03-07
4485 Nutritional quality and genetic differences of five amaranth cultivars revealed by metabolome profiling and whole-genome sequencing
Sedeek, K.; Zuccolo, A.; Toor, U. A.; Sanikommu, K.; Kantharajappa, S.; Riveraserna, L.; Wing, R. A.; Mahfouz, M. M.
10.1101/2025.03.03.641344 — plant biology — Posted on 2025-03-07
4488 Spatial instability affects Key Biodiversity Areas scoping for bumblebees across three decades
Nania, D.; Cristiano, A.; Mei, M.; Michez, D.; Di Musciano, M.; Cazzolla Gatti, R.; Merelli, P.; Pacifici, M.; Rondinini, C.; Cerretti, P.
10.1101/2025.03.01.640949 — ecology — Posted on 2025-03-07
4490 Decoding the Cognitive map: Learning place cells and remapping
Pettersen, M. B.; Schoyen, V. S.; Malthe-Sorenssen, A.; Lepperod, M. E.
10.1101/2024.03.14.585049 — neuroscience — Posted on 2025-03-07
4491 The microbiota affects stem cell decision making in Hydra
He, J.; Klimovich, A.; Kock, S.; Dahmke, L.; Franzenburg, S.; Bosch, T. C. G.
10.1101/2024.08.20.608462 — developmental biology — Posted on 2025-03-07
4492 Predicting Personalised Therapeutic Combinations in Non-Small Cell Lung Cancer Using In Silico Modelling
Clarke, M. A.; Barker, C. G.; Nicholls, A.; Handler, M. P.; Pickard, L.; Shah, A.; Walter, D.; De Braekeleer, E.; Banerji, U.; Choudhary, J.; Ahmad, S.; McDermott, U.; Hannon, G. J.; Fisher, J.
10.1101/2025.01.07.631497 — cancer biology — Posted on 2025-03-07
4494 Violated predictions enhance the representational fidelity of visual features in perception
Rideaux, R.; Dang, P.; Jackel-David, L.; Buhmann, Z.; Rangelov, D.; Mattingley, J. B.
10.1101/2024.03.27.587109 — neuroscience — Posted on 2025-03-07
4496 Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas
Kazansky, Y.; Mueller, H. S.; Cameron, D.; Demarest, P.; Zaffaroni, N.; Arrighetti, N.; Zuco, V.; Mundi, P. S.; Kuwahara, Y.; Somwar, R.; Qu, R.; Califano, A.; De Stanchina, E.; Dela Cruz, F. S.; Kung, A. L.; Gounder, M.; Kentsis, A.
10.1101/2024.05.03.592420 — cancer biology — Posted on 2025-03-07
4499 CIA: a Clustering Independent Annotation method to investigate cell identities in scRNA-seq data
Ferrari, I.; Battistella, M.; Vincenti, F.; Gobbini, A.; Marini, F.; Notarbartolo, S.; Costanza, J.; Biffo, S.; Grifantini, R. M.; Abrignani, S.; Galeota, E.
10.1101/2023.11.30.569382 — bioinformatics — Posted on 2025-03-07
4500 Structural annotation of full-scan MS data: A unified solution for LC-MS and MS imaging analyses
Xing, S.; Charron-Lamoureux, V.; Ekelöf, M.; El Abiead, Y.; Yu, H.; Fiehn, O.; Alexandrov, T.; Dorrestein, P. C.
10.1101/2024.10.14.618269 — bioinformatics — Posted on 2025-03-07
4503 Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma
Li, K.; Tolman, N.; V. Segre, A.; Stuart, K.; Zeleznik, O. A.; Vallabh, N. A.; Hu, K.; Zebardast, N.; Hanyuda, A.; Raita, Y.; Montgomery, C.; Zhang, C.; Hysi, P. G.; Do, R.; Khawaja, A.; Wiggs, J.; Kang, J.; John, S.; Pasquale, L.
10.1101/2025.01.18.633745 — genomics — Posted on 2025-03-07
4504 The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo
Shi, M.; Li, J.; Liu, X.; Liu, K.; He, L.; Pu, W.; Weng, W.; Zhang, S.; Zhao, H.; Lui, K.; Zhou, B.
10.1101/2024.04.23.590680 — genetics — Posted on 2025-03-07
4509 Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs
Kwon, T.; Trujillo, J. D.; Carossino, M.; Machkovech, H.; Cool, K.; Lyoo, E.; Singh, G.; Kafle, S.; Elango, S.; Vediyappan, G.; Wei, W.; Minor, N. R.; Matias Ferreyra, F.; Morozov, I.; Gaudreault, N. N.; Balasuriya, U.; Hensley, L.; Diel, D.; Ma, W.; Friedrich, T.; Richt, J. A.
10.1101/2025.03.04.641414 — microbiology — Posted on 2025-03-07
4511 Infection characteristics among Serratia marcescens capsule lineages.
Anderson, M. T.; Himpsl, S. D.; Kingsley, L. G.; Smith, S. N.; Bachman, M. A.; Mobley, H. L. T.
10.1101/2024.08.23.609398 — microbiology — Posted on 2025-03-07
4513 Inner limiting Membrane Peel Extends In vivo Calcium Imaging of Retinal Ganglion Cell Activity Beyond the Fovea in Non-Human Primate
Baez, H. C.; LaPorta, J. M.; Walker, A. D.; Fischer, W. S.; Hollar, R.; Patterson, S. S.; DiLoreto, D. A.; Gullapalli, V.; Mcgregor, J. E.
10.1101/2024.06.02.597041 — neuroscience — Posted on 2025-03-07
4514 Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.
Ishchenko, Y.; Jeng, A. T.; Feng, S.; Nottoli, T.; Manriquez-Rodriguez, C.; Nguyen, K.; Carrizales, M. G.; Vitarelli, M. J.; Corcoran, E. E.; Greer, C. A.; Myers, S. A.; Koleske, A. J.
10.1101/2024.01.05.574442 — neuroscience — Posted on 2025-03-07
4515 Computational neurodevelopment: infant decision-making in changing environments
Adams, R. A.; Billing, A.; Baljer, L.; Smith, E. S.; Cooper, R. J.; Lawson, R. P.
10.1101/2024.10.08.617314 — neuroscience — Posted on 2025-03-07
4516 Hierarchy between forelimb premotor and primary motor cortices and its manifestation in their firing patterns
Saiki-Ishikawa, A.; Agrios, M.; Savya, S.; Forrest, A.; Sroussi, H.; Hsu, S.; Basrai, D.; Xu, F.; Miri, A.
10.1101/2023.09.23.559136 — neuroscience — Posted on 2025-03-07
4517 Humans forage for reward in reinforcement learning tasks
Zid, M.; Laurie, V.-J.; Ramirez-Ruiz, J.; Lavigne-Champagne, A.; Shourkeshti, A.; Harrel, D.; Herman, A.; Ebitz, B.
10.1101/2024.07.08.602539 — neuroscience — Posted on 2025-03-07
4520 RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.
Flores Gonzalez, R. E.; Goncalves, C.; Wirasinghe, N.; Gaudeault, V.; Noda Ferro, J. M.; Coutant, K.; Mitchell, A.; Guettler, E.; Gonzalez Moreno, D. R.; Preston, S.; Cai, F.; Gagnon, N.; Jean, S.; Landreville, S.; Miller, W. H.; Del Rincon, S. V.
10.1101/2025.02.23.639782 — cancer biology — Posted on 2025-03-07
4522 Electrostatics facilitate mid-air host attachment in parasitic jumping nematodes
Ran, R.; Burton, J. C.; Kumar, S.; Bhamla, S.; Dillman, A. R.; Ortega-Jimenez, V. M.
10.1101/2025.02.20.639345 — biophysics — Posted on 2025-03-07
4523 Harnessing A Unified Multi-modal SequenceModeling to unveil Protein-DNA Interdependency
Li, M.; Ren, Y.; Ye, P.; Cheng, J.; Ma, X.; Cai, Y.; Ouyang, W.; Zhong, B.; Wu, B.; Dong, N.; Hong, L.; Tan, P.
10.1101/2025.02.26.640480 — bioinformatics — Posted on 2025-03-07
4524 Convergent evolutionary adaption of spider venom from predation to defense
Lueddecke, T.; Hurka, S.; Dresler, J.; Luebcke, T.; von Wirth, V.; Lochnit, G.; Timm, T.; Herzig, V.; Vilcinskas, A.
10.1101/2025.03.05.641688 — zoology — Posted on 2025-03-07
4526 The modifiers that cause changes in gene essentiality
Batte, A.; Bosch-Guiteras, N.; Pons, C.; Ota, M.; Lopes, M.; Sharma, S.; Tellini, N.; Paltenghi, C.; Conti, M.; Kan, K. T.; Ho, U. L.; Wiederkehr, M.; Barraud, J.; Ashe, M.; Aloy, P.; Liti, G.; Chabes, A.; Parts, L.; Van Leeuwen, J.
10.1101/2025.03.06.641712 — genomics — Posted on 2025-03-06
4530 Conserved strategies underpin the replicated evoluton of aridity tolerance in trees
Halliwell, B.; Blackman, C.; Gallagher, R.; Yates, L. A.; Britton, T.; Jones, R.; Nicolle, D.; Hartill, G.; Wright, I.; Holland, B.; Brodribb, T.
10.1101/2025.03.06.641812 — evolutionary biology — Posted on 2025-03-06
4535 The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration
Gümüsderelioglu, S.; Sahabandu, N.; Elnatan, D.; Gregory, E. F.; Chiba, K.; Niwa, S.; Luxton, G. G.; McKenney, R. J.; Starr, D. A.
10.1101/2025.03.06.641899 — cell biology — Posted on 2025-03-07
4536 An ultrastructural map of a spinal sensorimotor circuit reveals the potential of astroglia modulation
Koh, Z. M.; Arceo, R. A.; Hammer, J.; Chau, K.; Light, S. E. W.; Dolojan, A.; Januszewski, M.; Svara, F.; Smith, C. J.
10.1101/2025.03.05.641432 — neuroscience — Posted on 2025-03-06
4537 GABA mediates experience-dependent regulation of myelination in the mouse visual pathway.
Osanai, Y.; Battulga, B.; Yamazaki, R.; Kobayashi, K.; Kobayashi, K.; Nakamura, Y.; Ueno, M.; Mizukami, H.; Yoshimura, Y.; Ohno, N.
10.1101/2025.03.05.641594 — neuroscience — Posted on 2025-03-06
4538 Topographically organized dorsal raphe activity modulates forebrain sensory-motor computations and adaptive behaviors.
Mutlu, A. K.; Serneels, B.; Wiest, C.; Trinh, A.-T.; Bardenhewer, R.; Palumbo, F.; Frisvold, O. B.; Aukrus, I. K. F.; Ostenrath, A. M.; Yaksi, E.
10.1101/2025.03.06.641626 — neuroscience — Posted on 2025-03-06
4539 The relationship of white matter tract orientation to vascular geometry in the human brain
Schilling, K.; Newton, A.; Tax, C. M. W.; Chamberland, M.; Remedios, S. W.; Gao, Y.; Li, M.; Chang, C.; Rheault, F.; Sepherband, F.; Anderson, A. W.; Gore, J. C.; Landman, B. A.
10.1101/2025.03.06.641646 — neuroscience — Posted on 2025-03-06
4540 Impairment of homeostatic structural plasticity caused by the autism and schizophrenia-associated 16p11.2 duplication
Forrest, M. P.; Piguel, N.; Bagchi, V. A.; Dionisio, L. E.; Yoon, S.; Dos Santos, M.; LeDoux, M. S.; Penzes, P.
10.1101/2025.03.06.641931 — neuroscience — Posted on 2025-03-06
4545 How and when can environmental influences change cerebral cortex? An experimental training study of twins with birth weight differences
Walhovd, K. B.; Brathen, A. C. S.; Overbye, K.; Kransberg, J.; Sorensen, O.; Garrido, P. F.; Amlien, I. K.; Alatrorre-Warren, J.-L.; Mowinckel, A. M.; Falch, E. S.; Slivka, M.; Czajkowski, N. O.; Wang, Y.; Due-Tonnessen, P.; Fjell, A.; Sneve, M. H.
10.1101/2025.03.06.641380 — neuroscience — Posted on 2025-03-06
4549 Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.
Acera-Mateos, M.; Adiconis, X.; Li, J.-K.; Marchese, D.; Caratu, G.; Hon, C.-C.; Tiwari, P.; Kojima, M.; Vieth, B.; Murphy, M. A.; Simmons, S. K.; Lefevre, T.; Claes, I.; O'Connor, C. L.; Menon, R.; Otto, E. A.; Ando, Y.; Vandereyken, K.; Kretzler, M.; Bitzer, M.; Fraenkel, E.; Voet, T.; Enard, W.; Carnici, P.; Heyn, H.; Levin, J. Z.; Mereu, E.
10.1101/2025.03.06.637075 — genomics — Posted on 2025-03-06
4550 βTrCP is involved in the localization of the MRN complex on chromatin to enhance DNA damage repair
Belmonte-Fernandez, A.; Herrero-Ruiz, J.; Saez, C.; Japon, M. A.; Mora-Santos, M.; Romero, F.
10.1101/2025.03.06.640826 — cell biology — Posted on 2025-03-06
4553 Cerebellar involvement in self-timing
Boven, E.; Pickford, J.; Apps, R.; Cerminara, N. L.
10.1101/2025.03.05.641568 — neuroscience — Posted on 2025-03-06
4554 Biophysical basis for brain folding and misfolding patterns in ferrets and humans
Choi, G. P. T.; Yin, S.; Liu, C.; Sejourne, G.; Smith, R.; Walsh, C. A.; Mahadevan, L.
10.1101/2025.03.05.641682 — neuroscience — Posted on 2025-03-06
4557 A Universal Scaling Law for Mitotic Spindles Driven by Chromosome Crowding
Gudlin, L.; Vukusic, K.; Novak, M.; Trupinic, M.; Ljulj, M.; Dundovic, I.; Petelinec, A.; Petrusic, L.; Hertel, A.; van Ravesteyn, T.; Trakala, M.; Kops, G. J. P. L.; Storchova, Z.; Tambaca, J.; Pavin, N.; Tolic, I. M.
10.1101/2025.03.05.641650 — biophysics — Posted on 2025-03-06
4559 Saturation mapping of MUTYH variant effects using DNA repair reporters
Hemker, S. L.; Marsh, A.; Hernandez, F.; Glick, E.; Clark, G.; Bashir, A.; Jiang, K.; Kitzman, J. O.
10.1101/2025.03.01.640912 — genomics — Posted on 2025-03-06
4562 Generation and characterization of an ovine cell line derived from peripheral blood and its potential use to study livestock and zoonotic viral infections
Moreno, S.; Sanjurjo-Rodriguez, C.; Rodriguez-Fernandez, S.; Jimenez-Cabello, L.; Calvo-Pinilla, E.; Nogales, A.; Marin-Lopez, A.; Ortego, J.; Brun, A.; Diaz-Prado, S.; Lorenzo, G.
10.1101/2025.03.06.641825 — cell biology — Posted on 2025-03-06
4563 Constitutively active RAS prolongs Cdc42 signalling while attenuating MAPK signalling during fission yeast mating
Kelsall, E. J.; Kimura, A.; Vertesy, A.; Straatman, K.; Tariq, M.; Gadea, R.; Parmar, C.; Schreiber, G.; Randhawa, S.; Ida, T. Y.; Dominguez, C.; Klipp, E.; Tanaka, K.
10.1101/2025.03.06.641927 — cell biology — Posted on 2025-03-06
4564 Trained Immunity Affecting Dendritic Cell Differentiation and Function in Rheumatoid Arthritis
Tung, L. T.; Jiang, R. R.; Pozzebon, B.; Mancini, M.; Droin, L.; Yousefi, M.; Kim, J. E.; Mousa, M.; Liang, Y.; Krawczyk, C. M.; Colmegna, I.; Malo, D.; Langlais, D.; Vidal, S. M.; Nijnik, A.
10.1101/2025.02.28.640673 — immunology — Posted on 2025-03-06
4565 Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence
Hawes, S.; Liang, B.; Oldham, B.; Sullivan, B. T.; Song, B.; Chang, L.; Wang, L.; Lin, D.-T.; Cai, H.
10.1101/2025.02.28.640838 — neuroscience — Posted on 2025-03-06
4568 Multi-scale structural similarity embedding search across entire proteomes
Segura, J.; Sanchez Garcia, R.; Bittrich, S.; Rose, Y.; Burley, S.; Duarte, J.
10.1101/2025.02.28.640875 — bioinformatics — Posted on 2025-03-06
4570 The Genetic Basis of Chloride Exclusion in Grapevines
Sharma, S.; Cochetel, N.; Munoz, J.; Banayad, H.; Lupo, Y.; Nunez, V.; Gaspar, A.; Chen, C.; Bhattarai, K.; Cantu, D.; Diaz-Garcia, L.
10.1101/2025.02.28.640828 — genetics — Posted on 2025-03-06
4573 Human cytomegalovirus promotes de novo PC synthesis during early virus replication
Kline, I.; Mokry, R. L.; Xi, Y.; Passols Manzano, M.; Layesa, S.; Sohrab Ali, N.; Moy, M. A.; Goodrum, F.; Purdy, J. G.
10.1101/2025.03.06.641752 — microbiology — Posted on 2025-03-06
4574 Convergent evolution of a fungal effector enabling phagosome membrane penetration
Jia, L.-J.; Bernal, F. A.; Soehnlein, J.; Sonnberger, J.; Heineking, I.; Rafiq, M.; Cseresnyes, Z.; Kage, F.; Schmidt, F.; Zaher, R.; Hortschansky, P.; Chaudhary, S.; Gong, X.; Schirawski, J.; Figge, M. T.; Hube, B.; Brakhage, A. A.
10.1101/2025.03.06.641871 — microbiology — Posted on 2025-03-06
4577 Berberrubine Inhibits Helicobacter pylori by Inducing Oxidative Stress
Jiang, M.-Z.; Wang, C.-Y.; Wang, K.; Jiang, Y.; Wang, X.; Feng, X.-C.; Cao, S.-J.; Ding, L.-Q.; Bi, S.; Feng, Q.; Liu, S.; Liu, C.
10.1101/2025.03.06.641886 — microbiology — Posted on 2025-03-06
4578 DMBT1 promotes SARS-CoV-2 infection and its SRCR-derived peptide inhibits SARS-CoV-2 infection
Zhu, C.; Wang, Z.; Pan, Z.; Mai, X.; Chen, Y.; Zhang, W.; Zhao, P.; Tang, H.; Zhang, R.; Zhou, D.
10.1101/2025.03.06.641801 — microbiology — Posted on 2025-03-06
4582 The coronavirus helicase synergizes with the viral RNA polymerase to enable rapid RNA synthesis through duplex RNA
America, P.; BERA, S. C.; Das, A.; Anderson, T. K.; Marecki, J. C.; Papini, F. S.; Arnold, J. J.; Kirchdoerfer, R.; Cameron, C. E.; Raney, K. D.; Depken, M.; Dulin, D.
10.1101/2025.03.05.641625 — biophysics — Posted on 2025-03-06
4585 Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer
Jimenez-Sanchez, A.; Persad, S.; Hayashi, A.; Umeda, S.; Sharma, R.; Xie, Y.; Mehta, A.; Park, W.; Masilionis, I.; Chu, T.; Zhu, F.; Hong, J.; Chaligne, R.; O'Reilly, E. M.; Mazutis, L.; Nawy, T.; Pe'er, I.; Iacobuzio-Donahue, C. A.; Pe'er, D.
10.1101/2025.02.28.640922 — bioinformatics — Posted on 2025-03-06
4591 Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics
Amancherla, K.; Taravella Oill, A. M.; Bledsoe, X.; Williams, A. L.; Chow, N.; Zhao, S.; Sheng, Q.; Bearl, D. W.; Hoffman, R. D.; Menachem, J. N.; Siddiqi, H. K.; Brinkley, D. M.; Mee, E. D.; Hadad, N.; Agrawal, V.; Schmeckpepper, J.; Rali, A. S.; Tsai, S.; Farber-Eger, E. H.; Wells, Q. S.; Freedman, J. E.; Tucker, N. R.; Schlendorf, K. H.; Gamazon, E. R.; Shah, R. V.; Banovich, N.
10.1101/2025.02.28.640852 — genomics — Posted on 2025-03-06
4596 Synergistic interference with SARS-CoV-2 replication by Molnupiravir-derived N4 hydroxycytidine and inhibitors of CTP synthetase
Stegmann, K. M.; Dickmanns, A. M.; Fuchs, H. L.; Scheibner, D.; Mohl, B.-P.; Moeselaken, F.; Reineking, W.; Stoerk, T.; Volz, A.; Beer, P.; Parker, A.; Pilchova, V.; Meyer zu Natrup, C.; von Koeckritz-Blickwede, M.; Baumgaertner, W.; Balkema-Buschmann, A.; Dobbelstein, M.
10.1101/2025.03.06.641790 — microbiology — Posted on 2025-03-06
4597 Plasmodium falciparum PP1 phosphatase is a key regulator of malaria parasite transmission
Royer, L.; Colard-Itte, E.; Tavella, T. A.; Lorthiois, A.; Goussin, S.; N'Dri, M.-E.; Sabra, R.; Deiss, A.; Thiberge, S.; Lamarque, M. H.; Lavazec, C.
10.1101/2025.03.06.641796 — microbiology — Posted on 2025-03-06
4598 Fireworms (Hermodice carunculata) are a reservoir and potential vector for coral-infecting apicomplexans
Bonacolta, A. M.; Weiler, B. A.; Grimes, C. J.; Trznadel, M.; Vermeij, M. J. A.; Keeling, P. J.; del Campo, J.
10.1101/2025.03.06.641876 — microbiology — Posted on 2025-03-06
4599 Murine Leukemia Virus GlycoGag Antagonizes SERINC5 via ER-phagy Receptor RETREG1
Ahmad, I.; Zhang, J.; Li, R.; Su, W.; Liu, W.; Wu, Y.; Khan, I.; Liu, X.; Li, L.-F.; Li, S.; Zheng, Y.-H.
10.1101/2025.03.06.641798 — microbiology — Posted on 2025-03-06
4600 Effect of mosquito saliva from distinct species on human dermal endothelial cell function in vitro and West Nile virus pathogenesis in vivo
Visser, I.; Vaes, V.; van Run, P.; Marshall, E. M.; Vermaat, L.; Linthout, C.; Dekkers, D. H. W.; Demmers, J. A.; Koopmans, M.; Koenraadt, C.; Rissmann, M.; Rockx, B.
10.1101/2025.03.06.641838 — microbiology — Posted on 2025-03-06
4601 Tie2-Dependent Mechanisms Promote Leptomeningeal Collateral Remodeling and Reperfusion Following Stroke
Kaloss, A.; de Jager, C.; Lyles, K.; Groot, N.; Zhu, Y.; Lin, Y.; Xie, H.; Matson, J.; Theus, M.
10.1101/2025.02.28.640890 — neuroscience — Posted on 2025-03-06
4603 Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8
LaFlam, T. N.; Billesbolle, C. B.; Dinh, T.; Wolfreys, F. D.; Lu, E.; Matteson, T.; An, J.; Xu, Y.; Singhal, A.; Brandes, N.; Ntranos, V.; Manglik, A.; Cyster, J. G.; Ye, C. J.
10.1101/2025.02.28.640567 — genomics — Posted on 2025-03-06
4604 Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
Zhang, W.; Bradburn, D.; Heidebrink, G.; Liu, Y.; Jang, H.; Nussinov, R.; Koivomagi, M.
10.1101/2025.02.28.640857 — molecular biology — Posted on 2025-03-06
4605 An Alzheimer's disease-associated common regulatory variant in a PTK2B intron alters microglial function
Bello, E.; Long, K.; Iwama, S.; Steer, J.; Cooper, S. E.; Alasoo, K.; Kumasaka, N.; Schwartzentruber, J.; Panousis, N. I.; Bassett, A. R.
10.1101/2023.11.04.565613 — neuroscience — Posted on 2025-03-06
4606 Loop Catalog: a comprehensive HiChIP database of human and mouse samples
Reyna, J.; Fetter, K.; Ignacio, R.; Ali Marandi, C. C.; Ma, A.; Rao, N.; Jiang, Z.; Figueroa, D. S.; Bhattacharyya, S.; Ay, F.
10.1101/2024.04.26.591349 — bioinformatics — Posted on 2025-03-06
4607 Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions
Tang, R.; Ding, A.; Fu, C.; Umerori, K.; Rivera, M.; Alt, D. S.; Carmean, C. M.; Li, L.; Eppell, S. J.; Wynshaw-Boris, A.; Alsberg, E.
10.1101/2025.02.28.640824 — bioengineering — Posted on 2025-03-06
4608 Genomic surveillance of Methicillin Resistant Staphylococcus aureus in Saudi Arabia.
Alarawi, M. S.; Altammami, M.; H. Abutarboush, M.; Kulmanov, M.; Mawsil Alkuraythi, D.; Kafkas, S.; Radley, R.; Abdelhakim, M.; Aldakhil, H. M.; A. Bawazeer, R.; A. Alolayan, M.; M. Alnafjan, B.; A. Huraysi, A.; Almaabadi, A.; A Suliman, B.; G Aljohani, A.; A. Hemeg, H.; Abujamel, T. S.; Hashem, A. M.; Al-Zahrani, I. A.; S Abdoh, M.; I Hobani, H.; F Felemban, R.; A Alhazmi, W.; Hong, P.; Alghoribi, M. F.; Al Johani, S. M.; BALKHY, H. H.; Alswaji, A. A.; ALZAYER, M.; Alalwan, B.; Kaaki, M.; Hala, S.; Ahmad Fallatah, O.; Ahmad Bahitham, W.; Yahya Zakri, S.; A Alshehri, M.; Kameli, N.; Algaissi,
10.1101/2025.03.03.641358 — genomics — Posted on 2025-03-06
4610 The DNA damage response relies on the characteristics of ionizing particles in myogenic cells
Sutcu, H. H.; Thomas-Joyeux, A.; Cardot-Martin, M.; Dugue, D.; Vianna, F.; Benadjaoud, M. A.; Benderitter, M.; Baldeyron, C.
10.1101/2024.06.24.600399 — cell biology — Posted on 2025-03-06
4611 FabF-FadM Cooperate to Recycle Fatty Acids and Rescue ΔplsX Lethality in Staphylococcus aureus
Gruss, A.; Wongdontree, P.; Palmier, M.; Leguillier, V.; Louche, C.; Gloux, K.; Halpern, D.; Anba-Mondoloni, J.
10.1101/2024.12.18.629266 — microbiology — Posted on 2025-03-06
4612 Auditory training alters the cortical representation of complex sounds
Atilgan, H.; Walker, K. M. M.; King, A. J.; Schnupp, J.; Bizley, J. K.
10.1101/2023.12.29.573645 — neuroscience — Posted on 2025-03-06
4613 Evolution of lateralized gustation in nematodes
Mackie, M.; Le, V. V.; Carstensen, H. R.; Kushnir, N. R.; Castro, D. L.; Dimov, I. M.; Quach, K. T.; Cook, S. J.; Hobert, O.; Chalasani, S. H.; Hong, R. L.
10.1101/2024.08.31.610597 — neuroscience — Posted on 2025-03-06
4619 Engineered human cartilage matrix exhibits potent immunoregulatory properties while promoting full skeletal repair in pre-clinical models
Garcia Garcia, A.; Prithiviraj, S.; Raina, D. B.; Schmidt, T.; Baudet-Quintino, A.; Gonzalez Anton, S.; Rabanal Cajal, L.; Gil, D. H.; Kahn, R.; Tagil, M.; Bourgine, P. E.
10.1101/2025.01.10.632347 — bioengineering — Posted on 2025-03-06
4621 A spatiotemporally resolved GPCR interactome reveals novel mediators of receptor agonism
Shchepinova, M. M.; Richardson, R.; Houghton, J. W.; Walker, A. R.; Safar, M. A.; Conole, D.; Hanyaloglu, A. C.; Tate, E. W.
10.1101/2024.06.14.599010 — biochemistry — Posted on 2025-03-06
4623 Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders
Zhou, Z.; Luquette, L. J.; Dong, G.; Kim, J.; Ku, J.; Kim, K.; Bae, M.; Shao, D. D.; Sahile, B.; Miller, M. B.; Huang, A. Y.; Park, P. J.; Lagier-Tourenne, C.; Lee, E. A.; Walsh, C. A.
10.1101/2025.03.03.641186 — genomics — Posted on 2025-03-06
4624 Convergent evolution during host range expansion and virulence increase in a Salmonella bacteriophage
Maurin, A.; Vasse, M.; Zarate-Chaves, C.; breyton, C.; Bouzidi, S.; hayer, J.; Dainat, J.; Mesleard-Roux, M.; Weill, F.-X.; Bravo, I. G.; Feugier, A.; Froissart, R.
10.1101/2024.03.13.584857 — microbiology — Posted on 2025-03-06
4627 Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
Pradhan, S.; Dhar, D.; Manna, D.; Chakraborty, S.; Bhattacharyya, A.; Chauhan, K.; Mukherjee, R.; Sen, A.; Pandey, K.; Das, S.; Mukherjee, B.
10.1101/2024.10.21.619374 — microbiology — Posted on 2025-03-06
4628 AgRP1 modulates breeding season-dependent feeding behavior in female medaka
Tagui, Y.; Takeda, S.; Waida, H.; Kitahara, S.; Kimura, T.; Kanda, S.; Oka, Y.; Hayashi, Y.; Umatani, C.
10.1101/2024.07.10.602830 — neuroscience — Posted on 2025-03-06
4631 Activated Notch1 Redirects CD4-Fated CD4+ CD8+ Precursors to the CD8 Lineage During Thymocyte Selection Without Causing T Cell Leukemia
El-Maklizi, M.; Kousis, P. C.; Yuan, J. S.; MacDonald, B.; Gams, M. S.; Gower, M.; Boudil, A.; Guidos, C. J.
10.1101/2025.02.28.640858 — immunology — Posted on 2025-03-06
4634 Storage protein biosynthesis is affected by ionome composition in soybean (Glycine max (L.) Merrill) seeds
Montanha, G. S.; Perez, L. C.; Lepri, A.; Longo, C.; Marzi, D.; Santos, E.; Franco, F. S.; Paparotto Lopes, G.; da Cruz da Silva, N. G.; Marques, J. P. R.; De Almeida, E.; Virgilio, A.; Perez, C. A.; Vittorioso, P.; Sabatini, S.; Linhares, F. S.; Pereira De Carvalho, H. W.
10.1101/2025.02.28.640933 — plant biology — Posted on 2025-03-06
4636 Integrating metabolic scaling and coexistence theories
Saavedra, S.; Arroyo, J. I.; Deng, J.; Marquet, P. A.; Kempes, C. P.
10.1101/2023.02.28.530509 — ecology — Posted on 2025-03-06
4639 Host genotype shapes root mycobiota in durum wheat
TRINQUIER, M.; COLOMBO, M.; FREVILLE, H.; JACQUES, D.; ROCHER, A.; LEFEBVRE, B.; ROUX, C.
10.1101/2024.10.27.616629 — plant biology — Posted on 2025-03-06
4640 Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP protein
Stubbe, M.; Stubbe, H. C.; Mai, J.; Plank, V.; Hofmann, S.; Goettig, L.; Guenther, T.; Grundhoff, A.; Krebs, S.; Groitl, P.; Mayerle, J.; Hay, R. T.; Dobner, T.; Schreiner, S.
10.1101/2025.02.07.636424 — cell biology — Posted on 2025-03-06
4643 Real-Time Tracking of Tumor Invasion Dynamics in Organotypic Brain Slices at Subcellular Resolution
Petr, J. B.; Lin, M.-S.; Hochuli, D.; Hierlemann, A.; Baumgartner, M. B.; Modena, M. M.
10.1101/2025.02.28.640791 — bioengineering — Posted on 2025-03-06
4644 The organizer as a cooperative of signaling cells for neural induction
Lu, H.-C.; Trevers, K. E.; Solovieva, T.; Anderson, C.; Perez-Campos, L.; Filipkova, L.; Arimia, V.; Colle, C.; De Oliveira, N. M. M.; Dale, L.; Stern, C. D.
10.1101/2025.03.05.641623 — developmental biology — Posted on 2025-03-06
4645 MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos.
Godden, A. M.; Ward, N.; Sittewelle, M.; Antonaci, M.; Kotov, A.; Monsoro-Burq, A. H.; Wheeler, G. N. N.
10.1101/2025.03.05.641602 — developmental biology — Posted on 2025-03-06
4646 Sp100A isoform promotes HIRA histone chaperone localization to PML nuclear bodies
Della Fera, A. N.; Arman, W.; Powers, M. E.; Warburton, A.; McBride, A. A.
10.1101/2025.03.06.641437 — cell biology — Posted on 2025-03-06
4647 Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis
Park, C.; Baek, K. I.; Jeong, K.; Kim, P.; Hung, R.-C.; Choi, L.; Chou, C.-L.; Kang, D. W.; Song, E. J.; Kim, Y.; van der Laan, S. W.; Pasterkamp, G.; Villa-Roel, N.; Panitch, A.; Jo, H.
10.1101/2025.03.06.641843 — cell biology — Posted on 2025-03-06
4648 A Drosophila model for Dent disease reveals impaired ER export of Cubilin as pathogenic mechanism
Christer, S.; Marelja, Z.; Hauschild, H.; Berquez, M.; Dibra, I.; Shih, Y.-H.; Helmstaedter, M.; Devuyst, O.; Simons, M.
10.1101/2025.03.05.641445 — cell biology — Posted on 2025-03-06
4651 Phase separation drives SNARE complexes formation
Chen, F.; Ke, Q.; Feng, S.; Chen, H.; Haung, Q.; Ma, F.; Cai, Y.; Chen, J.; Li, S.; Wei, W.; Sun, Y.; Peng, X.; Tong, L.; Sun, X.; Deng, L.; Wang, Y.; Cui, L.
10.1101/2025.03.04.641570 — neuroscience — Posted on 2025-03-06
4652 Peripheral Beta-Blockade Differentially Enhances Cardiac and Respiratory Interoception
Tyrer, A.; Fischer Ehmsen, J.; Hoogervorst, K.; Nikolova, N.; Pando-Naude, V.; Holm Steenkjaer, C.; Courtin, A. S.; Fardo, F.; Hauser, T.; Bavato, F.; Allen, M.
10.1101/2025.02.28.640776 — neuroscience — Posted on 2025-03-06
4653 Parabrachial Calca neurons influence aversive and appetitive taste function
Lemon, C. H.; Li, J.; Ali, M. S. S.; Ngum, N. M.; Zumpano, K. T.; Roberts, C. J.
10.1101/2025.02.28.640892 — neuroscience — Posted on 2025-03-06
4654 C9orf72-ALS mutation drives mitophagy impairments in iNeurons
Lee, J. A. K.; Granger, S.; Roome, K.; Allen, S.; Ferraiuolo, L.; Shaw, P.; Mortiboys, H. J.
10.1101/2025.02.28.640849 — neuroscience — Posted on 2025-03-06
4655 Amyloid beta is released by lysosomal exocytosis from hiPSC-derived neurons
Tsang, A. R.; Medapati, M. R.; Seah, C.; Krupa, J. M.; Pasternak, S. H.
10.1101/2025.03.01.640950 — neuroscience — Posted on 2025-03-06
4658 Towards robust machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles
Rotteveel, A.; Lee, W.-Y.; Kountouri, Z.; Stefanou, N.; Kivell, H.; Gluck, C.; Zhang, S.; Mershin, A.
10.1101/2024.11.19.624273 — cancer biology — Posted on 2025-03-06
4663 SaprotHub: Making Protein Modeling Accessible to All Biologists
Su, J.; Li, Z.; Han, C.; Zhou, Y.; He, Y.; Shan, J.; Zhou, X.; Chang, X.; Jiang, S.; Ma, D.; The OPMC, ; Steinegger, M.; Ovchinnikov, S.; Yuan, F.
10.1101/2024.05.24.595648 — bioinformatics — Posted on 2025-03-06
4665 Immune Cells Infiltration of Patient Derived Glioblastoma Cells spheroids in Acoustic Levitation in Bulk Acoustic Wave devices
Mousset, X.; Kuermanbayi, S.; Dupuis, C.; Jeger-Madiot, N.; Delaunay, V.; Ahmed, I.; El-Habr, E. A.; Chneiweiss, H.; Junier, M.-P.; Aider, J.-L.; PEYRIN, J. M.
10.1101/2025.02.28.640539 — bioengineering — Posted on 2025-03-06
4666 Genome-wide CRISPR knockout screen reveals the landscape of essential genes across the porcine genome
Harvey, T. N.; Boyartchuk, V.; van Son, M.; Gjuvsland, A. B.; Grindflek, E.; Kent, M. P.
10.1101/2025.02.28.640817 — genomics — Posted on 2025-03-06
4667 Mutations and structural variants arising during double-strand break repair
Dalin, S.; Webster, S.; Sugawara, N.; Wu, Q.; Zhang, S.; Macias, C.; Sapede, E.; Cui, T.; Liang, V.; Tran, L.; Beroukhim, R.; Haber, J. E.
10.1101/2025.02.28.640809 — genetics — Posted on 2025-03-06
4668 Historic Genomes Uncover Demographic Shifts and Kinship Structures in Post-Roman Central Europe
Blöcher, J.; Vallini, L.; Velte, M.; Eckel, R.; Guyon, L.; Winkelbach, L.; Thomas, M. G.; Gharehbaghi, N.; Mitchell, C. T.; Schümann, J.; Köhler, S.; Seyr, E.; Krichel, K.; Rau, S.; Hirsch, J.; Duras, J.; Klement, K.; Wilkenhöner, M.; Vetterdietz, L.; Gentilin, F.; Müller, M.; Mücke, A.-L.; Zedda, N.; Tawfik, Y.; Saal, E.; McGlynn, G.; Bramanti, B.; Orschiedt, J.; Molitor, R.; Fliss, B.; Spazier, I.; Shankland, D.; Vetterling, C.; Karpf, K.; Planert, V.; Hölzl, S.; Codreanu-Windauer, S.; Quast, D.; Mikic, I.; Päffgen, B.; Brami, M.; Richter, T.; Chaix, R.; Brather-Walter, S.; Steffens,
10.1101/2025.03.01.640862 — genetics — Posted on 2025-03-06
4669 Cell jamming transitions shape regulatory protein gradients and prime evolutionary divergence
Badyaev, A. V.; Lee, C. A.; Gleason, M. J.; Semenov, G. A.; Britton, S. E.; Moreno, C. S.; Duckworth, R. A.
10.1101/2025.03.05.641736 — evolutionary biology — Posted on 2025-03-06
4672 Flexibility in movement strategies of neotropical nectarivorous birds: insights from high-Andean hummingbirds and flowerpiercers
Rueda-Uribe, C.; Camargo-Martinez, P. A.; Espitia, J.; Lozano-Rocha, M.; Rios, J. P.; Echeverry-Galvis, M. A.; Lancaster, L. T.; Capellini, I.; Travis, J. M. J.; Rico-Guevara, A.
10.1101/2025.02.28.640730 — ecology — Posted on 2025-03-06
4674 Common to rare transfer learning (CORAL) enables inference and prediction for a quarter million rare Malagasy arthropods
Ovaskainen, O.; Winter, S.; Tikhonov, G.; Abrego, N.; Anslan, S.; deWaard, J. R.; deWaard, S. L.; Fisher, B. L.; Furneaux, B.; Hardwick, B.; Kerdraon, D.; Pentinsaari, M.; Raharinjanahary, D.; Rajoelison, E. T.; Ratnasingham, S.; Somervuo, P.; Sones, J. E.; Zakharov, E. V.; Hebert, P. D. N.; Roslin, T.; Dunson, D.
10.1101/2024.08.21.608960 — ecology — Posted on 2025-03-06
4675 E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding
Houtekamer, R. M.; van der Net, M. C.; Vliem, M. J.; Noordzij, T. E. J. C.; van Uden, L.; van Es, R. M.; Sim, J. Y.; Deguchi, E.; Terai, K.; Hopcroft, M. A.; Vos, H. R.; Pruitt, B. P.; Matsuda, M.; Pannekoek, W.-J.; Gloerich, M.
10.1101/2025.03.06.641828 — cell biology — Posted on 2025-03-06
4677 Towards a Kingdom of Reproductive Life - the Core Sperm Proteome
Pini, T.; Nixon, B.; Karr, T. L.; Teperino, R.; Sanz-Moreno, A.; da Silva-Buttkus, P.; Tuettelmann, F.; Kliesch, S.; Gailus-Durner, V.; Fuchs, H.; Marschall, S.; Hrabe de Angelis, M.; Skerrett-Byrne, D. A.
10.1101/2025.03.06.641666 — cell biology — Posted on 2025-03-06
4678 Inwardly rectifying potassium channels regulate membrane potential polarization and direction sensing during neutrophil chemotaxis
Wang, T.; Kim, D. H.; Ding, C.; Wang, D.; Zhang, W.; Silic, M.; Cheng, X.; Shao, K.; Ku, T.; Zheng, C.; Xie, J.; Yuan, C.; Chubykin, A.; Staiger, C. J.; Zhang, G.; Deng, Q.
10.1101/2025.03.06.641746 — cell biology — Posted on 2025-03-06
4679 Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
Shimazoe, M. A.; Phillips, C.; Huertas, J.; Ide, S.; Tamura, S.; Farr, S.; Ashwin, S. S.; Sasai, M.; Collepardo-Guevara, R.; Maeshima, K.
10.1101/2025.03.05.641622 — cell biology — Posted on 2025-03-06
4680 Fluorescence Lifetime Unmixing: A New Workflow for FLIM Live-Cell Imaging
Wetzker, C.; Zoccoler, M. L.; Iarovenko, S.; Okafornta, C. W.; Nobst, A.; Hartmann, H.; Mueller-Reichert, T.; Haase, R.; Fabig, G.
10.1101/2025.03.05.641717 — cell biology — Posted on 2025-03-06
4681 Stage-Specific MCM Protein Expression in Trypanosoma cruzi: Insights Into Metacyclogenesis and G1 Arrested epimastigotes.
Santarossa, B. A.; Mariani, E.; Correa, A. d. P.; Costa, F. C.; Taylor, M. C.; Kelly, J. M.; Elias, M. C.; Calderano, S. G.
10.1101/2025.03.05.641675 — cell biology — Posted on 2025-03-06
4682 HSP70 chaperones IL-33 in chronic airway disease
Osorio, O. A.; Kluender, C. E.; Raphael, H. E.; Hassan, G. F.; Cohen, L. S.; Steinberg, D.; Katz-Kiriakos, E.; Payne, M. D.; Luo, E. M.; Hicks, J. L.; Byers, D. E.; Alexander-Brett, J.
10.1101/2025.01.30.635799 — immunology — Posted on 2025-03-06
4684 A left-lateralized dorsolateral prefrontal network for naming
Yu, L.; Dugan, P.; Doyle, W.; Devinsky, O.; Friedman, D.; Flinker, A.
10.1101/2024.05.15.594403 — neuroscience — Posted on 2025-03-06
4686 HP1-enhanced chromatin compaction stabilizes a synthetic metabolic circuit in yeast
Gonzalez, L.; Echauri, S. A. G.; Jeronimo, C.; Poitras, C.; Gencel, M.; Serohijos, A.; Bloom, K. S.; Robert, F.; Avalos, J. L.; Michnick, S. W.
10.1101/2025.03.04.641524 — synthetic biology — Posted on 2025-03-06
4688 Inhibition of mTORC1 by rapamycin results in feedback activation of Akt S473 and aggravates hallmarks of osteoarthritis in female mice and non-human primates
Minton, D. M.; Ailiani, A. R.; Focht, M. D. K.; Kersh, M. E.; Lii, A.; Elliehausen, C. J.; Sonsalla, M. M.; Lamming, D. W.; Marolf, A. J.; Santangelo, K. S.; Salmon, A. B.; Konopka, A. R.
10.1101/2024.05.14.594256 — physiology — Posted on 2025-03-06
4691 T-cell receptor specificity landscape revealed through de novo peptide design
Visani, G. M.; Pun, M. N.; Minervina, A. A.; Bradley, P. H.; Thomas, P.; Nourmohammad, A.
10.1101/2025.02.28.640903 — biophysics — Posted on 2025-03-06
4692 Structural basis of ZP2-targeted immunocontraception
Dioguardi, E.; Stsiapanava, A.; Fahrenkamp, E.; Han, L.; de Sanctis, D.; Inzunza, J.; Jovine, L.
10.1101/2025.03.03.641048 — biophysics — Posted on 2025-03-06
4696 Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions
Tang, R.; Ding, A.; Fu, C.; Umerori, K.; Rivera, M.; Alt, D. S.; Carmean, C. M.; Li, L.; Eppell, S.; Wynshaw-Boris, A.; Alsberg, E.
10.1101/2025.02.28.640824 — bioengineering — Posted on 2025-03-06
4698 Parallel Sensory Compensation following Independent Subterranean Colonization by Groundwater Salamanders (Eurycea )
Tovar, R. U.; Dobbins, B. A.; Hartman, N. R.; Leelani, S. A.; Devitt, T. J.; Garcia, D. M.; Gignac, P. M.; Cannatella, D. C.; Hillis, D. M.
10.1101/2025.03.02.640989 — evolutionary biology — Posted on 2025-03-06
4699 Seeing in the deep: evolution of the opsin gene expression in Bermin crater lake cichlids
Kłodawska, M.; Indermaur, A.; Bitja Nyom, A. R.; Omelchenko, D.; Bartos, O.; Musilova, Z.
10.1101/2025.02.28.640660 — evolutionary biology — Posted on 2025-03-06
4700 Rapid temporal adaptation structures tolerance to toxic cyanobacteria in a natural population of the water flea Daphnia.
Fajgenblat, M.; Gouwy, E.; Coone, M.; Almeida, R.; Boudry, A.; Cuypers, K.; van den Berg, E.; Vanoverberghe, I.; De Meester, L.; Decaestecker, E.
10.1101/2025.02.28.640829 — evolutionary biology — Posted on 2025-03-06
4703 The magnitude of cryptic insect diversity in one tropical rainforest
Basset, Y.; Lamarre, G. P. A.; Donoso, D. A.; Souto-Vilaros, D.; Perez, F.; Bobadilla, R.; Lopez, Y.; Ramirez Silva, J. A.; Barrios, H.
10.1101/2025.02.28.640797 — evolutionary biology — Posted on 2025-03-06
4706 Herbarium specimens reveal a constrained seasonal climate niche despite diverged annual climates across a wildflower clade
Bontrager, M.; Worthy, S. J.; Cacho, N. I.; Leventhal, L.; Maloof, J.; Gremer, J. R.; Schmitt, J.; Strauss, S. Y.
10.1101/2025.02.28.640808 — ecology — Posted on 2025-03-06
4707 Macrogenetic atlas of prokaryotes
Yang, C.; Huang, H.; Wang, N.; Didelot, X.; Yang, R.; Cui, Y.; Falush, D.
10.1101/2025.02.26.640246 — microbiology — Posted on 2025-03-06
4715 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-03-06
4716 Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells
Ichikawa, T.; Kono, Y.; Kudo, M.; Shimi, T.; Miyashita, N.; Maesaka, T.; Ishibashi, K.; Sivashanmugan, K.; Yoshida, T.; Miyazawa, K.; Hanayama, R.; Hirata, E.; Miyata, K.; Kimura, H.; Fukuma, T.
10.1101/2024.12.13.626302 — biophysics — Posted on 2025-03-06
4720 Chemical diversity promotes ecosystem function
Fonvielle, J.; Sandor, S. R.; Dittmar, T.; Tanentzap, A. J.
10.1101/2025.02.16.638531 — ecology — Posted on 2025-03-06
4721 A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate
Brooks, E. R.; Moorman, A. R.; Bhattacharya, B.; Prudhomme, I. S.; Land, M.; Alcorn, H. L.; Sharma, R.; Pe'er, D.; Zallen, J. A.
10.1101/2024.08.25.609458 — developmental biology — Posted on 2025-03-06
4722 Bacterial sirtuin CobB and PRPP synthase crosstalk in the regulation of protein acetylation in Escherichia coli
Walter, B. M.; Morcinek-Orlowska, J.; Szulc, A.; Lovering, A. L.; Haycocks, J. R. J.; Banzhaf, M.; Glinkowska, M. K.
10.1101/2020.12.09.417477 — molecular biology — Posted on 2025-03-06
4724 HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels
Kmiec, D.; Nchioua, R.; Gabel, A.; Vlachou, A.; Ganskih, S.; Erdemci-Evin, S.; Lapp, S. A.; Carnathan, D.; Bosinger, S. E.; Berkhout, B.; Das, A. T.; Munschauer, M.; Kirchhoff, F.
10.1101/2024.10.13.618097 — microbiology — Posted on 2025-03-06
4725 Anti-tumor immunity relies on targeting tissue homeostasis through monocyte-driven responses rather than direct tumor cytotoxicity
Koelsch, N.; Mirshahi, F.; Aqbi, H. F.; Saneshaw, M.; Idowu, M. O.; Olex, A. L.; Sanyal, A. J.; Manjili, M. H.
10.1101/2024.06.12.598563 — immunology — Posted on 2025-03-06
4726 A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
Peres, A.; Upadhyay, A. A.; Klein, V. H.; Saha, S.; Rodriguez, O. L.; Vanwinkle, Z. M.; Karunakaran, K.; Metz, A.; Lauer, W.; Lin, M. C.; Melton, T.; Granholm, L.; Polak, P.; Peterson, S. M.; Peterson, E. J.; Raju, N.; Shields, K.; Schultze, S.; Ton, T.; Ericsen, A.; Lapp, S. A.; Villinger, F. J.; Ohlin, M.; Cottrell, C.; Amara, R. R.; Derdeyn, C. A.; Crotty, S.; Schief, W.; Karlsson Hedestam, G. B.; Smith, M.; Lees, W.; Watson, C. T.; Yaari, G.; Bosinger, S. E.
10.1101/2025.01.07.631319 — immunology — Posted on 2025-03-06
4727 Dopamine and temporal discounting: revisiting pharmacology and individual differences
Smith, E.; Theis, H.; van Eimeren, T.; Knauth, K.; Tuzsus, D.; Zhang, L.; Mathar, D.; Peters, J.
10.1101/2024.08.28.610170 — neuroscience — Posted on 2025-03-06
4728 Mitochondrial dysfunction drives a neuronal exhaustion phenotype in methylmalonic aciduria
Denley, M. C. S.; Straub, M. S.; Marcionelli, G.; Güra, M. A.; Penton, D.; Delvendahl, I.; Poms, M.; Vekeriotaite, B.; Cherkaoui, S.; Conte, F.; von Meyenn, F.; Froese, D. S.; Baumgartner, M. R.
10.1101/2024.03.15.585183 — neuroscience — Posted on 2025-03-06
4729 Efficient elastic tissue motions indicate general motor skill
Namburi, P.; Pallares-Lopez, R.; Folgado, D.; Magana-Salgado, U.; Ryu, E.; Kappacher, A.; Gamboa, H.; Anthony, B. W.; Daniel, L.
10.1101/2025.02.25.636457 — physiology — Posted on 2025-03-06
4730 Elevated Lactate in the AML Bone Marrow Microenvironment Polarizes Leukemia-Associated Macrophages via GPR81 Signaling
Soto, C. A.; Lesch, M. L.; Becker, J. L.; Sharipol, A.; Khan, A.; Shafer, X. L.; Becker, M. W.; Munger, J. C.; Frisch, B. J.
10.1101/2023.11.13.566874 — pathology — Posted on 2025-03-06
4731 The age-related deceleration of clonal haematopoiesis in 420,000 healthy adults
MacGregor, H. A.; Tran, D.; Bolton, K. L.; Easton, D.; Blundell, J. R.
10.1101/2023.12.21.572706 — genomics — Posted on 2025-03-06
4732 High-quality genome assembly for the genetically improved Abbassa Nile tilapia enables the reconstruction of X and Y haplotypes
Etherington, G. J.; Ciezarek, A.; Mehta, T.; Barker, T.; Durant, A.; Fraser, F.; Henderson, S.; Irish, N.; Kaithakottil, G. G.; Knitlhoffer, V.; Ali, S.; Trong, T.; Watkins, C.; Swarbreck, D.; Gharbi, K.; Benzie, J. A.; Haerty, W.
10.1101/2025.02.28.640774 — genomics — Posted on 2025-03-06
4736 Exogenous melatonin mitigates drought stress by promoting the living cortical area of roots in cotton
Zhang, H.; Guo, C.; Sun, H.; Zhu, L.; Zhang, K.; Zhang, Y.; Wang, Z.; Li, C.; Liu, L.
10.1101/2025.02.28.640717 — physiology — Posted on 2025-03-05
4737 SARS CoV-2 spike adopts distinct conformational ensembles in situ
Gramm, A. J.; Braet, S. M.; Srinivasu, B. Y.; Venkatakrishnan, V.; Bass, E. J.; Kearns, F. L.; Calvo-Tusell, C.; Amaro, R. E.; Stahelin, R. V.; Wales, T. E.; Anand, G. S.
10.1101/2025.03.04.641425 — biophysics — Posted on 2025-03-05
4738 Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy
Kerlin, M. A.; Aboulfath-Ladid, I.; Roensch, J.; Jaubert, C.; Battistella, A.; Borgman, K. J. E.; Coulon, A.
10.1101/2025.03.04.641491 — biophysics — Posted on 2025-03-06
4743 The inflammatory skin disease map (ISD map): an interactive computational resource focused on psoriasis and atopic dermatitis molecular mechanisms
Acencio, M.; Lopata, O.; Hemedan, A.; Dand, N.; Weidinger, S.; Paternoster, L.; Brown, S.; Rastrick, J.; Smith, C.; Hubenthal, M.; Ramessur, R.; Ndlovu, M.; Ghosh, S.; Wang, X.; Schneider, R.; Satagopam, V.; Ostaszewski, M.
10.1101/2025.02.28.640747 — bioinformatics — Posted on 2025-03-05
4745 Cell lineage inference from mitochondrial mutations
Hard, J.; Seidel, S.; Ferreira, P.; Berkes, P.; Jahn, K.; Eriksson, C.-J.; Mold, J. E.; Michaelsson, J.; Kuipers, J.; Beerenwinkel, N.
10.1101/2025.02.28.640740 — bioinformatics — Posted on 2025-03-05
4747 Predicting allergy and postpartum depression from incomplete compositional microbiome
Shternshis, A.; Tong, B.; Wahlby, C.; Zachariah, D.; Hugerth, L. W.; Singh, P.
10.1101/2025.02.28.640766 — bioinformatics — Posted on 2025-03-06
4750 Self-supervised learning enables unbiased patient characterization from multiplexed microscopy images
Atarsaikhan, G.; Mogollon, I.; Valimaki, K.; iCAN, ; Mirtti, T.; Pellinen, T.; Paavolainen, L.
10.1101/2025.03.05.640729 — bioinformatics — Posted on 2025-03-06
4755 Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy
Arifova, L.; MacTavish, B. S.; Laughlin, Z.; Karadi Girdhar, M. N.; Shang, J.; Li, M.-H.; Yu, X.; Zhu, D.; Kamenecka, T. M.; Kojetin, D.
10.1101/2025.03.04.640448 — biochemistry — Posted on 2025-03-05
4756 Multiple LPA3 receptor agonist binding sites evidenced under docking and functional studies
Solis, K. H.; Romero-Avila, M. T.; Rincon-Heredia, R.; Correa-Basurto, J.; SAINZ, J. A. G.
10.1101/2024.09.03.611107 — biochemistry — Posted on 2025-03-05
4759 Design and Synthesis of Potent First-in-Class Histones Acetyltransferase Modulators.
Zuccarello, E.; Mori, M.; Calcagno, E.; Purgatorio, R.; Feng, Y.; Acquarone, E.; Francis, Y. I.; Fa', M.; Staniszewski, A.; Argyrousi, E. K.; Barry, C. D.; Zhang, H.; Deng, S.-X.; Landry, D. W.; Arancio, O.; Fiorito, J.
10.1101/2025.03.03.641271 — biochemistry — Posted on 2025-03-05
4760 New insights into the metabolomic signatures of spontaneously hypertensive rats
Rodriguez Perez, C.; Vazquez Aguilar, A.; Rangel, O.; Sanchez Rodriguez, E.; Gil, A.; Diaz, C.; Vargas, F.; Mesa, M. D.
10.1101/2025.02.28.640925 — biochemistry — Posted on 2025-03-06
4761 Caloric restriction reprograms adipose tissues in rhesus monkeys
Clark, J. P.; Rhoads, T. W.; McIlwain, S. J.; Polewski, M. A.; Pavelec, D.; Colman, R. J.; Anderson, R. M.
10.1101/2025.03.03.641286 — genomics — Posted on 2025-03-05
4763 Genomic surveillance of Methicillin Resistant Staphylococcus aureus in Saudi Arabia.
Alarawi, M. S.; Altammami, M.; H. Abutarboush, M.; Kulmanov, M.; Mawsil Alkuraythi, D.; Kafkas, S.; Radley, R.; Abdelhakim, M.; Aldakhil, H. M.; A. Bawazeer, R.; A. Alolayan, M.; M. Alnafjan, B.; A. Huraysi, A.; Almaabadi, A.; A Suliman, B.; G Aljohani, A.; A. Hemeg, H.; Abujamel, T. S.; Hashem, A. M.; Al-Zahrani, I. A.; S Abdoh, M.; I Hobani, H.; F Felemban, R.; A Alhazmi, W.; Hong, P.; Alghoribi, M. F.; Al Johani, S. M.; BALKHY, H. H.; Alswaji, A. A.; ALZAYER, M.; Alalwan, B.; Kaaki, M.; Hala, S.; Ahmad Fallatah, O.; Ahmad Bahitham, W.; Yahya Zakri, S.; A Alshehri, M.; Kameli, N.; Algaissi,
10.1101/2025.03.03.641358 — genomics — Posted on 2025-03-06
4764 Speed-accuracy trade-offs in Roulette betting
Chen, S.; Srinivasa Gopalakrishnan, G. P.; Marantan, A.; Mahadevan, L.
10.1101/2025.03.04.641449 — animal behavior and cognition — Posted on 2025-03-05
4767 Genetic context of transgene insertion can influence neurodevelopment in zebrafish
Moyer, A. J.; Barcus, A.; Capps, M. E.; Chrabasz, J. A.; Lalonde, R. L.; Mosimann, C.; Thyme, S. B.
10.1101/2025.02.28.640904 — genetics — Posted on 2025-03-05
4769 Characterisation of guided entry of tail-anchored proteins in Magnaporthe oryzae
Abah, F.; Zheng, Q.; Chen, X.; Huang, L.; Chen, X.; Biregeya, J.; Aron, O.; Wang, Z.; Tang, W.
10.1101/2025.02.28.640736 — genetics — Posted on 2025-03-05
4770 Transposable element co-option drives transcription factor neofunctionalization
ROSSPOPOFF, O.; Milovanovic, D.; Offner, S.; Lau, K.; Duhoo, Y.; Duc, J.; Planet, E.; Raclot, C.; Damery, C.; Begnis, M.; Pojer, F.; Trono, D.
10.1101/2025.03.01.640934 — genetics — Posted on 2025-03-06
4771 Unravelling genetic differentiation between Glossina brevipalpis populations from two distant National Parks in Mozambique
Brito, D. R. A.; Segard, A.; Mulandane, F. C.; Cossa, N.; Mucache, H. N.; Ravel, S.; De Meeus, T.; Neves, L.
10.1101/2025.02.28.640735 — evolutionary biology — Posted on 2025-03-05
4778 Foraging Ants as Liquid Brains: Movement Heterogeneity Shapes Collective Efficiency
Fernandez-Lopez, P.; Oro, D.; Lloret-Cabot, R.; Genovart, M.; Garriga, J.; Bartumeus, F.
10.1101/2025.02.28.640754 — ecology — Posted on 2025-03-05
4779 A single amino acid variant in the variable region I of AAV capsid confers liver detargeting
Xing, R.; Xu, M.; Reil, D.; Destefano, A.; Cui, M.; Liu, N.; Liang, J.; Xu, G.; Luo, L.; Xu, M.; Zhang, F.; Tai, P. W.; Gruntman, A. M.; Flotte, T. R.; Gao, G.; Wang, D.
10.1101/2025.03.04.641478 — molecular biology — Posted on 2025-03-05
4781 Transcriptomic meta-analysis in plaque psoriasis: an integrative bioinformatic approach to deciphering the genetic landscape and molecular pathways
Torres-Moral, T.; Riera-Monroig, J.; Tell-Marti, G.; Bague, J.; Catala-Senent, J. F.; Roig, F. J.; Potrony, M.; Garcia-Garcia, F.; Puig, S.
10.1101/2025.03.01.640943 — molecular biology — Posted on 2025-03-05
4782 Sources and sinks of influenza A virus genomic diversity in swine from 2009 to 2022 in the United States
Janzen, G. M.; Inderski, B. T.; Chang, J.; Arendsee, Z. W.; Janas-Martindale, A.; Torchetti, M. K.; Baker, A. L.; Anderson, T. K.
10.1101/2025.03.04.641516 — microbiology — Posted on 2025-03-05
4785 Phosphorylation State Dictates Bacterial Stressosome Assembly and Function
Martinez-Bond, E.; Lopez-Ayala, I.; lobanovska, M.; Qiu, L.; Yu, Z.; Garda, V.; Portnoy, D. A.; Mckenzie-Williams, A. H.
10.1101/2025.03.04.640944 — microbiology — Posted on 2025-03-05
4787 ITAF45 is a Pervasive Trans Acting Factor for Picornavirus Type II IRES Elements
Bellucci, M. A.; Amiri, M.; Berryman, S.; Moshari, A.; Owino, C. O.; Luteijn, R.; Tuthill, T. J.; Svitkine, Y.; Belsham, G. J.; van Kuppeveld, F. J. M.; Sonenberg, N.
10.1101/2025.03.05.641721 — microbiology — Posted on 2025-03-05
4788 Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling
Carrillo, N. D.; Chen, M.; Wen, T.; Awasthi, P.; Wolfe, T. J.; Sterling, C.; Cryns, V. L.; Anderson, R. A.
10.1101/2023.05.08.539894 — cell biology — Posted on 2025-03-05
4790 Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis
Valerio, V.; Massaiu, I.; Franchi, M.; Rimbert, A.; Begue-Racape, Z.; Chiesa, M.; Myasoedova, V. A.; Rusconi, V.; Bertolini, F.; De Giorgi, D.; Bonomi, A.; Pirola, S.; Zanobini, M.; Di Pietro, P.; Carrizzo, A.; Ciccarelli, M.; Capoulade, R.; Genovese, S.; Poggio, P.
10.1101/2025.03.03.641336 — cell biology — Posted on 2025-03-06
4791 Mesenteric ischemia and bacterial translocation precipitate the intoxication phase of yellow fever
Thomazella, M. V.; Qiu, X.; Silveira, C. G. T.; Correia, C. A.; Marmorato, M. P.; Sanson, E.; Norton, A.; Sharobim, M.; Ho, Y.-L.; Dolhnikoff, M.; Matkovic, E.; Neto, A. N. D.; Kallas, E.; Bailey, A.
10.1101/2025.03.05.641677 — microbiology — Posted on 2025-03-05
4792 Extracellular vesicles from chylomicron-treated endothelial cells drive macrophage inflammation
Tilp, A.; Nasias, D.; Carley, A. N.; Park, M. Y.; Mooring, A.; Tirumalasetty, M.; Abumrad, N. A.; Wang, Y.; Miao, Q. R.; Lewandowski, E. D.; Aleman, J. O.; Goldberg, I. J.; Cabodevilla, A. G.
10.1101/2025.02.28.640926 — cell biology — Posted on 2025-03-06
4794 Regulation of Female Reproductive Aging by the Spag17 Gene
Ericsson, V.; Elam, M.; Sapao, P.; Nguyen, L. M. T.; Gill, M. E.; Chodavarapu, S.; Cordova-Fletes, C.; Lafrenaye, A.; Hassan, S.; Mahendroo, M.; Chen, L.; Petitjean, M.; Strauss, J. F.; Varga, J.; Duncan, F. E.; Teves, M. E.
10.1101/2025.03.01.640648 — cell biology — Posted on 2025-03-06
4795 Behavioral Manipulation of Ixodes scapularis by Ehrlichia muris eauclairensis: Implications for Tick-Borne Disease Transmission
Aspinwall, J.; Weck, B.; Martins, L. A.; Jarrett, C. O.; Suzuki, M.; Peyton, M. P.; Sonenshine, D. E.; Saito, T. B.
10.1101/2025.03.04.641579 — microbiology — Posted on 2025-03-05
4796 Examining the Survival of A(H5N1) Influenza Virus in Thermised Whole Cow Milk
Nasheri, N.; Alkie, T. N.; cutts, T.; Pama, l.; Romero-Barrios, P.; Catford, A.; Hooper-McGrevy, K.; Berhane, Y.
10.1101/2025.03.05.641644 — microbiology — Posted on 2025-03-06
4798 Comprehensive genomic analysis of Klebsiella pneumoniae and its temperate N-15-like phage: From isolation to functional annotation
Yahya, R.; Albaqami, A.; Alzahrani, A.; Althubiti, S.; Alhariri, M.; Alrashidi, E. T.; Alhazmi, N.; Al-Matary, M. A.; Alharbi, N.
10.1101/2025.03.05.641587 — microbiology — Posted on 2025-03-06
4800 Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution
Cook, S. J.; Kalinski, C. A.; Loer, C. M.; Memar, N.; Majeed, M.; Stephen, S. R.; Bumbarger, D. J.; Riebesell, M.; Conradt, B.; Schnabel, R.; Sommer, R. J.; Hobert, O.
10.1101/2024.06.13.598904 — neuroscience — Posted on 2025-03-05
4801 FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
Li, J. T.-Y.; Amiri, M.; Kailasam, S.; Sun, J.; Sonenberg, N.; Ortega, J.; Sossin, W. S.
10.1101/2025.02.21.639553 — neuroscience — Posted on 2025-03-05
4803 Sensory expectations shape neural population dynamics in motor circuits
Michaels, J. A.; Kashefi, M.; Zheng, J.; Codol, O.; Weiler, J.; Kersten, R.; Lau, J. C.; Gribble, P. L.; Diedrichsen, J.; Pruszynski, J. A.
10.1101/2024.12.22.629295 — neuroscience — Posted on 2025-03-05
4805 Common but different: An ERP study of single- and multi-source interference processing in MSIT
Paluch, K.; Antonova, I.; Nikadon, J.; Dzianok, P.; Jurewicz, K.; Wojciechowski, J.; Kublik, E.
10.1101/2025.03.05.641477 — neuroscience — Posted on 2025-03-06
4807 Identification of a specific set of genes predicting obesity before phenotype appearance
Jousse, C.; Parry, L.; Cueff, G.; Brandolini-Bunlon, M.; Tournayre, J.; Bruhat, A.; Maurin, A.-C.; Vituret, C.; Averous, J.; Muranishi, Y.; Fafournoux, P.
10.1101/2025.02.28.640741 — physiology — Posted on 2025-03-05
4808 Mustard-DB: The Database of Cellular, Molecular, and Phenotypic Data in Sulphur Mustard Exposure
Ahmadi, A.; Rafiei, F.; Alizadeh, M.; Chitsaz, A.; Ghasemi, S.; Bagheri, H.; Ghazvini, A.; Arabfard, M.; Azimzadeh, S.; Ghanei, M.
10.1101/2025.03.02.639327 — bioinformatics — Posted on 2025-03-05
4810 Improving Predictability, Test-Retest Reliability and Generalisability of Brain-Wide Associations for Cognitive Abilities via Multimodal Stacking
Tetereva, A.; Knodt, A.; Melzer, T.; van der Vliet, W.; Gibson, B.; Hariri, A.; Whitman, E. T.; Li, J.; Lal Khakpoor, F.; Deng, J.; Ireland, D.; Ramrakha, S.; Pat, N.
10.1101/2024.05.03.589404 — neuroscience — Posted on 2025-03-05
4811 Multimodal personalization of transcranial direct current stimulation for modulation of sensorimotor integration
Radecke, J.-O.; Kuehn, A.; Erdbruegger, T.; Buschermoehle, Y.; Rashidi, S.; Stoeckler, H.; Sack, B.; Borgwardt, S.; Schneider, T. R.; Gross, J.; Wolters, C. H.; Sprenger, A.; Lencer, R.
10.1101/2024.11.06.622280 — neuroscience — Posted on 2025-03-05
4813 Real-time transcriptomic profiling in distinct experimental conditions
Butto, T.; Pastore, S.; Mueller, M.; Iyer, K. V.; Joerg, M.; Brechtel, J.; Muendnich, S.; Wierczeiko, A.; Friedland, K.; Helm, M.; Winz, M.-L.; Gerber, S.
10.1101/2024.03.26.586831 — bioinformatics — Posted on 2025-03-05
4814 Surface Wetting Is a Key Determinant of α-Synuclein Condensate Maturation
Thrush, R. J.; Vadukul, D. M.; Allerton, S. C.; Storch, M.; Aprile, F. A.
10.1101/2024.06.06.597302 — biochemistry — Posted on 2025-03-05
4819 Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs
Kwon, T.; Trujillo, J. D.; Carossino, M.; Machkovech, H.; Cool, K.; Lyoo, E.; Singh, G.; Kafle, S.; Elango, S.; Vediyappan, G.; Wei, W.; Minor, N. R.; Matias Ferreyra, F.; Morozov, I.; Gaudreault, N. N.; Balasuriya, U.; Hensley, L.; Diel, D.; Ma, W.; Friedrich, T.; Richt, J. A.
10.1101/2025.03.04.641414 — microbiology — Posted on 2025-03-05
4820 SwiftMHC: A High-Speed Attention Network for MHC-Bound Peptide Identification and 3D Modeling
Xue, L. C.; Baakman, C.; Crocioni, G.; Rademaker, D. T.; Aarts, Y. J. M.; Fruehbuss, D.
10.1101/2025.01.20.633893 — immunology — Posted on 2025-03-05
4823 Cortical sensory aging is layer-specific
Liu, P.; Doehler, J.; Henschke, J. U.; Northall, A.; Serian, A.; Loaiza-Carvajal, L. C.; Budinger, E.; Schwarzkopf, D. S.; Speck, O.; Pakan, J. M. P.; Kuehn, E.
10.1101/2023.12.01.567841 — neuroscience — Posted on 2025-03-05
4824 PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database
Greco, B. M.; Zapata, G.; Dandage, R.; Papkov, M.; Pereira, V.; Lefebvre, F.; Bourque, G.; Parts, L.; Kuzmin, E.
10.1101/2025.03.04.641431 — systems biology — Posted on 2025-03-05
4829 On ARGs, pedigrees, and genetic relatedness matrices
Lehmann, B.; Lee, H.; Anderson-Trocme, L.; Kelleher, J.; Gorjanc, G.; Ralph, P. L.
10.1101/2025.03.03.641310 — genomics — Posted on 2025-03-05
4831 RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters
Wiechers, H.; Williams, C. J.; Eltzner, B.; Hoppe, F.; Prisant, M. G.; Chen, V. B.; Miller, E.; Mardia, K. V.; Richardson, J. S.; Huckemann, S. F.
10.1101/2025.02.06.636803 — molecular biology — Posted on 2025-03-05
4832 Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders
Zhou, Z.; Luquette, L. J.; Dong, G.; Kim, J.; Ku, J.; Kim, K.; Bae, M.; Shao, D. D.; Sahile, B.; Miller, M. B.; Huang, A. Y.; Park, P. J.; Lagier-Tourenne, C.; Lee, E. A.; Walsh, C. A.
10.1101/2025.03.03.641186 — genomics — Posted on 2025-03-05
4838 Open EGGbox: an open-source 3D-printed embryonic Gallus gallus toolbox for electroporation and culture/live imaging of avian embryos ex ovo
Antoniou-Kourantonio, M.; Ramirez de Acuna, F.; Schettler, R. C. C.; Udar, S. K.; Hamzic Petite, A.; Sivasubramanian, R. V.; Munsterberg, A. E.; Grocott, T.
10.1101/2025.03.04.641180 — developmental biology — Posted on 2025-03-04
4839 Adaptive Clonal Expansion Shapes Brain Development
Di Muzio, G.; Benedetto, S.; Wang, L.-C.; Weber, L.; van der Hoeven, F.; Armstrong, B.; Lu, H.-J.; Berlanda, J.; Koerber, V.; Claudino, N.; Krogemann, M.; Hoefer, T.; Wei, P.-C.
10.1101/2025.03.04.641452 — developmental biology — Posted on 2025-03-04
4844 Sex-biased Transcriptome in in vitro Produced Bovine Early Embryos
Shi, M.; Li, G.; Araujo, H. M.; Lee, A. S.; Zhang, J.; Lee, Y. L.; IISAGE Consortium, ; Cheong, S. H.; Duan, J. E.
10.1101/2025.03.04.641446 — developmental biology — Posted on 2025-03-04
4847 The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration.
Li, X.-J.; Morgan, C.; Li, L.; Zhang, W.-Y.; Chrysostomou, E.; Doetzlhofer, A.
10.1101/2025.03.02.640998 — developmental biology — Posted on 2025-03-04
4848 Single-Nucleotide m6A Mapping Uncovers Redundant YTHDF Function in Planarian Progenitor Fate Selection
Yesharim, Y.; Shwarzbard, O.; Barboy-Smoliarenko, J.; Shachar, R.; Palavalli, A.; Vu, H. T.-K.; Schwartz, S.; Wurtzel, O.
10.1101/2025.03.03.641144 — developmental biology — Posted on 2025-03-04
4850 Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heart
MacDonald, L.; Hardy, O.; Toitou, M.; Kania, G.; Blyszczuk, P.; Micheroli, R.; Otto, T.; Kurowska-Stolarska, M.; Ospelt, C.
10.1101/2025.03.04.641204 — cell biology — Posted on 2025-03-04
4851 Quantification of lipid sorting during clathrin-mediated endocytosis
Lennartz, H. M.; da Costa Nunes, S.; Böhlig, K.; Kuhn, S. M.; Moneta, L.; Yau, W. Y.; Opalka, L.; Iglesias-Artola, J. M.; Modes, C. D.; Honigmann, A.; Nadler, A.
10.1101/2025.03.04.641423 — cell biology — Posted on 2025-03-04
4854 Functional Impact of CYFIP2 RNA Editing on Actin Regulation, Axon Growth, and Spinogenesis
La Via, L.; Ndoj, E.; Bertoli, M.; Mutti, V.; Carini, G.; Filippini, A.; Bono, F.; Fiorentini, C.; Ribaudo, G.; Gianoncelli, A.; Borsani, G.; Russo, I.; Barbon, A.
10.1101/2025.03.04.641430 — cell biology — Posted on 2025-03-04
4855 Human Milk Oligosaccharides Modulate Inflammatory Responses and Lipid Metabolism in a Human Intestinal Organoid Model
Slater, E.; Park, J.; Dennison, T.; Mak, T.; Bendik, I.; Rehman, A.; Mussler, B.; Wiens, F.; Nayak, K.; Zilbauer, M.
10.1101/2025.03.04.640785 — cell biology — Posted on 2025-03-04
4856 A novel RNP compartment boosts translation in growing mouse oocytes to avoid cytoplasm dilution
Zollo, N.; Zaffagnini, G.; Canette, A.; Letort, G.; Da Silva, C.; Tessandier, N.; Dumont, J.; Blugeon, C.; Lemoine, S.; Wattellier, B.; Boke, E.; Almonacid, M.; Verlhac, M.-H.
10.1101/2025.03.04.641373 — cell biology — Posted on 2025-03-04
4858 Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Kroczek, L.; Nolte, H.; Lasarzewski, Y.; Molinie, T.; Curbelo Pinero, D.; Lemke, K.; Rugarli, E.; Langer, T.
10.1101/2025.03.04.641455 — cell biology — Posted on 2025-03-05
4859 AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes
Ji, Z.; Pandey, T.; Belly, H. d.; Wang, B.; Weiner, O. K.; Tang, Y.; Guang, S.; Yao, J.; Xu, S.; Lou, Z.; Goddard, T.; Ma, D. K.
10.1101/2024.06.19.599784 — cell biology — Posted on 2025-03-05
4860 Human hypothalamic neural stem cells transplantation ameliorates age-associated dysfunction through SNS/eNAMPT axis activation in aged mice
Sulistio, Y. A.; Pieknell, K.; Hong, S.; Lee, Y.; Kim, M. S.; Park, W.-Y.; Han, K. Y.; Hong, T.; Park, K.-S.; Yoon, S. G.; Kim, I. Y.; Seong, J. K.; Lee, T. Y.; Kim, M. S.; Lee, S.-H.
10.1101/2024.05.23.595504 — cell biology — Posted on 2025-03-05
4861 Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease
Cox, D.; Burke, M.; Milani, S.; White, M. A.; Waldron, F. M.; Böken, D.; Lobanova, E.; Sreedharan, J.; Gregory, J. M.; Klenerman, D.
10.1101/2025.03.04.641150 — molecular biology — Posted on 2025-03-05
4862 Emulating Visual Evaluations in the Microscopic Agglutination Test with Deep Learning
Nakano, R.; Oyamada, Y.; Ozuru, R.; Miyahara, S.; Yoshimura, M.; Hiromatsu, K.
10.1101/2024.04.09.588741 — microbiology — Posted on 2025-03-05
4863 The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies.
Krawczyk, M.; Fernandez-Fuentes, N.; Fidyt, K.; Winiarski, T.; Pepek, M.; Graczyk-Jarzynka, A.; Davis, J.; Bousquets-Munoz, P.; Puente, X. S.; Menendez, P.; Benard, E.; Walchli, S.; Thomas-Tikhonenko, A.; Winiarska, M.
10.1101/2025.02.28.640707 — immunology — Posted on 2025-03-05
4864 Ex vivo human brain volumetry: validation of magnetic resonance imaging measurements
Gerin-Lajoie, A.; Adame-Gonzalez, W.; Frigon, E.-M.; Sanches, L. G.; Nayouf, A.; Boire, D.; Dadar, M.; Maranzano, J.
10.1101/2025.02.27.640654 — neuroscience — Posted on 2025-03-04
4866 A modular, adaptable, and accessible implant kit for chronic electrophysiological recordings in rats
Alcala, R. J. I.; Macias, A. Y.; Heaton, C. N.; Jurado, R. S.; Salcido, A. A.; Reyes, N. F.; Batson, S. A.; Davila, L. D.; Beck, D. W.; Rakocevic, L. I.; Giri, A.; Negishi, K.; Drammis, S. M.; Goosens, K. A.; Moschak, T. M.; Friedman, A.
10.1101/2025.02.27.640674 — neuroscience — Posted on 2025-03-04
4868 Sleep Deprivation Alters Hippocampal Dendritic Spines in a Contextual Fear Memory Engram
Tennin, M.; Matkins, H. T.; Rexrode, L.; Bollavarapu, R.; Asplund, S. D.; Pareek, T.; Kroeger, D.; Pantazopoulos, H.; Gisabella, B.
10.1101/2025.03.02.641043 — neuroscience — Posted on 2025-03-05
4870 Motifs of brain cortical folding from birth to adulthood: structural asymmetry and folding-functional links
Guo, Y.; Suliman, M. A.; Williams, L. Z. J.; Besenczi, R.; Liang, K.; Dahan, S.; Kyriakopoulou, V.; McAlonan, G. M.; Hammers, A.; O'Muircheartaigh, J.; Robinson, E. C.
10.1101/2025.03.04.641459 — neuroscience — Posted on 2025-03-05
4871 mTORC1 activation drives astrocyte reactivity in cortical tubers and brain organoid models of TSC
Li, T. L.; Blair, J. D.; Yoo, T.; Grant, G. A.; Hockemeyer, D.; Porter, B. E.; Bateup, H. S.
10.1101/2025.02.28.640914 — neuroscience — Posted on 2025-03-05
4872 Biological subtyping of autism via cross-species fMRI
Pagani, M.; Zerbi, V.; Gini, S.; Alvino, F.; Banerjee, A.; Barberis, A.; Basson, A.; Bozzi, Y.; Galbusera, A.; Ellegood, J.; Fagiolini, M.; Lerch, J.; Matteoli, M.; Montani, C.; Pozzi, D.; Provenzano, G.; Scattoni, M. L.; Wenderoth, N.; Xu, T.; Lombardo, M.; Milham, M.; Di Martino, A.; Gozzi, A.
10.1101/2025.03.04.641400 — neuroscience — Posted on 2025-03-05
4874 Distinct molecular mechanisms of stress habituation in the mouse hippocampus
Waag, R.; von Ziegler, L.; Sturman, O.; Sonder, E.; Leonardi, J.; Frei, S.; Gapp, K.; Germain, P.-L.; Bohacek, J.
10.1101/2025.03.04.641433 — neuroscience — Posted on 2025-03-05
4876 Growing Minds, Integrating Senses: Neural and Computational Insights into Age-related Changes in Audio-Visual and Tactile-Visual Learning in Children
Raduner, N.; Providoli, C.; Di Pietro, S.; Schneebeli, M.; Karipidis, I. I.; Casimiro, E.; Bedi, S.; Von Rhein, M.; Raschle, N. M.; Ruff, C. C.; Brem, S.
10.1101/2025.03.04.639748 — neuroscience — Posted on 2025-03-05
4877 Learning reorganizes dendritic and stabilizes axonal initial segment inhibitory synapses in CA1 pyramidal neurons
Klimmt, H.; Kappel, D.; Ulivi, A. F.; Argunsah, A. O.; Murthy, B.; Somatakis, S.; Huettl, R. E.; Remy, S.; Attardo, A.
10.1101/2025.03.04.641429 — neuroscience — Posted on 2025-03-05
4879 Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency
Zhang, J.; Eaton, M.; Chen, X.; Zhao, Y.; Kant, S.; Deming, B. A.; Harish, K.; Nguyen, H. P.; Shu, Y.; Lai, S.; Wu, J.; Que, Z.; Wettschurack, K. W.; Zhang, Z.; Xiao, T.; Halurkar, M. S.; Olivero-Acosta, M. I.; Yoo, Y.-E.; Lanman, N. A.; Koss, W. A.; Skarnes, W. C.; Yang, Y.
10.1101/2025.03.04.641498 — neuroscience — Posted on 2025-03-05
4882 Multimodal personalization increases the efficacy of transcranial direct current stimulation for modulation of sensorimotor integration
Radecke, J.-O.; Kuehn, A.; Erdbruegger, T.; Buschermoehle, Y.; Rashidi, S.; Stoeckler, H.; Sack, B.; Borgwardt, S.; Schneider, T. R.; Gross, J.; Wolters, C. H.; Sprenger, A.; Lencer, R.
10.1101/2024.11.06.622280 — neuroscience — Posted on 2025-03-05
4884 Inhibitors of oncogenic Kras specifically prime CTLA4 blockade to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer
Mahadevan, K. K.; Maldonado, A. S.; Li, B.; Bickert, A. A.; Perdyan, A.; Kumbhar, S. V.; Piya, S.; Sockwell, A. M.; Morse, S. J.; Arian, K.; Sugimoto, H.; Shalapour, S.; Hong, D. S.; Heffernan, T. P.; MAITRA, A.; Kalluri, R.
10.1101/2025.02.28.640711 — cancer biology — Posted on 2025-03-04
4887 Osteoarthritis leads to more contractile and protrusive chondrocytes when cultured in 3D degradable hydrogels
Vovchenko, M.; Vaes, N.; Barrasa-Fano, J.; Shapeti, A.; Castro Vinuelas, R.; Kimps, L.; Glorieux, C.; Jonkers, I.; Van Oosterwyck, H.
10.1101/2025.02.27.640613 — bioengineering — Posted on 2025-03-04
4891 Energetic failure and oxidative stress underlie the Prpf31 splicing factor-related mouse phenotype
Hamieh, F.; Vanoni, E. M.; Rieu, Q.; Enderlin, J.; Hadjout, N.; Lew, D. S.; Potey, A.; Millet-Puel, G.; Leveillard, T.; Nandrot, E. F.
10.1101/2025.02.28.640751 — pathology — Posted on 2025-03-04
4894 Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production
O'Brien, C. J. O.; Ratti, G.; Veida-Silva, H.; Haberman, E. R.; Sweeney, C. A. P.; Gordon, S.; Domingos, A. I.
10.1101/2023.09.26.559578 — immunology — Posted on 2025-03-05
4896 Effects of ancient anthropogenic clam gardens on the growth, survival, and transcriptome of Pacific littleneck clams (Leukoma staminea)
Raap, M. R.; Gurney-Smith, H. J.; Dudas, S. E.; Pearce, C. M.; Leong, J. S.; Sutherland, B. J. G.; Koop, B. F.
10.1101/2022.09.09.507365 — ecology — Posted on 2025-03-04
4897 Cortico-spinal Mechanisms of TENS-induced Analgesia: A Single-Blind, Three-Arm, fMRI-Based Randomized Controlled Trial
Wei, Z.; Duan, Y.; Zhu, Y.; Lin, X.; Zhang, L.; Zhang, M.; Brooks, J. C. W.; Liu, Y.; Hu, L.; Kong, Y.
10.1101/2024.02.06.579059 — neuroscience — Posted on 2025-03-04
4900 Targeted and random mutagenesis of cassava brown streak disease susceptibility factors reveal molecular determinants of disease severity
Lin, Z.-J. D.; Stanton, M. K.; Hernandez, G. L.; De Meyer, E. J.; von Behren, Z.; Benza, K.; Tiley, H.; Hood, E.; Jensen, G.; Gilbert, K. B.; Carrington, J.; Bart, R.
10.1101/2025.02.27.640518 — plant biology — Posted on 2025-03-04
4901 rRNA depletion for holobiont metatranscriptome profiling across demosponges
Vargas, S.; Rivera-Vicens, R. E.; Eitel, M.; Buettner, G.; Leiva, L.; Woerheide, G.
10.1101/2022.08.12.503726 — genomics — Posted on 2025-03-04
4902 Characterization of Woodsmoke Generated in the Air Pollution Exposure Lab and Comparison to Diesel Exhaust
Xi, Y.; Hardy, K.; Choudhary, V.; Zaks, J.; Schwartz, C.; Rider, C. F.; Bertram, A. K.; Carlsten, C.
10.1101/2025.02.27.640457 — pharmacology and toxicology — Posted on 2025-03-04
4903 Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools
Keele, G. R.; Dzieciatkowska, M.; Hay, A. M.; Vincent, M.; O'Connor, C.; Stephenson, D.; Reisz, J. A.; Nemkov, T.; Hansen, K.; Page, G. P.; Zimring, J. C.; Churchill, G. A.; D'Alessandro, A. A.
10.1101/2025.02.27.640676 — genomics — Posted on 2025-03-04
4907 PERRC: Protease Engineering with Reactant Residence Time Control
Nelson, S.; Gaza, J.; Ajayebi, S.; Masse, R.; Pho, R.; Scutero, C.; Martinusen, S.; Long, L.; Menezes, A.; Perez, A.; Denard, C.
10.1101/2025.03.02.641063 — synthetic biology — Posted on 2025-03-04
4909 Culturomics from field-grown crop plants using dilution-to-extinction, two-step library preparation and amplicon sequencing
Lopez-Echartea, E.; Dusek, N.; Misialek, M.; Mahmud-Un-Nabi, M. A.; Wiliamson, R.; Marathe, K.; Geddes, B. A.
10.1101/2025.03.04.641206 — microbiology — Posted on 2025-03-04
4910 scBaseCamp: An AI agent-curated, uniformly processed, and continually expanding single cell data repository
Youngblut, N. D.; Carpenter, C.; Prashar, J.; Ricci-Tam, C.; Ilango, R.; Teyssier, N.; Konermann, S.; Hsu, P.; Dobin, A.; Burke, D. P.; Goodarzi, H.; Roohani, Y. H.
10.1101/2025.02.27.640494 — bioinformatics — Posted on 2025-03-04
4914 Enzymatic synthesis of diverse oligoamide polymer precursors
Qian, L.; Dishner, I. T.; Carper, D. L.; Kertesz, V.; Zolnierczuk, N. T.; Thiele, N. A.; Cahill, J. F.; Foster, J. C.; Michener, J. K.
10.1101/2025.02.28.640842 — biochemistry — Posted on 2025-03-04
4916 No evidence that human GIGYF2 interacts with growth factor receptor-bound protein 10 (GRB10): implication for human disease
Choi, J.-H.; Shpilman, I.; Mahmood, N.; Farhangmehr, S.; Braunschweig, U.; Luo, J.; Ladak, R. J.; Pistofidis, A.; Schmeing, T. M.; Jafarnejad, S. M.; Blencowe, B. J.; Sonenberg, N.
10.1101/2025.02.28.640929 — molecular biology — Posted on 2025-03-04
4919 Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
Zhang, W.; Bradburn, D.; Heidebrink, G.; Liu, Y.; Jang, H.; Nussinov, R.; Koivomagi, M.
10.1101/2025.02.28.640857 — molecular biology — Posted on 2025-03-04
4920 Transposon-directed insertion-site sequencing (TraDIS) analysis of Enterococcus faecium using nanopore sequencing and a WebAssembly analysis platform
Krause, A. L.; Wirth, W.; Turner, A. M.; Judd, L.; Li, L.; van Schaik, W.; Howden, B. P.; Carter, G. P.; Seemann, T.; Wick, R. R.; Stinear, T. P.; Buultjens, A. H.; Monk, I. R.
10.1101/2025.03.03.641140 — microbiology — Posted on 2025-03-04
4922 VIRGO2: Unveiling the Functional and Ecological Complexity of the Vaginal Microbiome with an Enhanced Non-Redundant Gene Catalog
France, M.; Chaudry, I.; Rutt, L.; Quain, M.; Shirtliff, B.; McComb, E.; Maros, A.; Alizadeh, M.; Hussain, F.; Elovitz, M.; Relman, D.; Rahman, A.; Brotman, R. M.; Price, J. T.; Kassaro, M.; Holm, J. B.; Ma, B.; Ravel, J.
10.1101/2025.03.04.641479 — microbiology — Posted on 2025-03-04
4924 Correlative In Situ Cryo-ET Reveals Cellular and Viral Remodeling Associated with Selective HIV-1 Core Nuclear Import
Hou, Z.; Shen, Y.; Fronik, S.; Shen, J.; Shi, J.; Xu, J.; Chen, L.; Hardenbrook, N.; Thompson, C.; Neumann, S.; Engelman, A. N.; Aiken, C.; zhang, p.
10.1101/2025.03.04.641496 — microbiology — Posted on 2025-03-04
4925 When non-canonical olfaction is optimal
Lienkaemper, C.; Younger, M. A.; Ocker, G. K.
10.1101/2025.02.27.640624 — neuroscience — Posted on 2025-03-04
4928 Global distribution of microbial carrageenan foraging pathways reveals widespread latent traits within the genetic dark matter of ruminant intestinal microbiomes
Tingley, J. P.; Anderson, T. O.; mihalynuk, L. G.; Xing, X.; Low, K. E.; Whiteside, D. P.; Shearer, A. Y.; Altshuler, I.; Jujihara, N.; Serin, S.; Smith, E.; Reintjes, G.; Patel, T. R.; Boraston, A. B.; Hagen, L. H.; Pope, P. B.; Abbott, D. W.
10.1101/2025.03.04.641501 — microbiology — Posted on 2025-03-04
4929 Enantiomer-Specific Malathion Degradation by Gut Microbes of the Colorado Potato Beetle
Blanton, A. G.; Olds, M.; Martinez, J. A.; Putman, J.; Armstrong, D. W.; Ravenscraft, A.
10.1101/2025.03.04.641399 — microbiology — Posted on 2025-03-04
4930 Lipid Phase Behavior of the Curvature Region of Thylakoid Membranes of Spinacia oleracea. Isotropic Phase around the CURT1 Protein
Böde, K.; Trotta, A.; Dlouhy, O.; Javornik, U.; Paakkarinen, V.; Fujii, H.; Domonkos, I.; Zsiros, O.; Plavec, J.; Spunda, V.; Aro, E.-M.; Garab, G.
10.1101/2024.11.12.623231 — plant biology — Posted on 2025-03-04
4931 Environmental microbiomes drive chemotactile sensation in octopus
Sepela, R. J.; Jiang, H.; Shin, Y.-H.; Clardy, J.; Hibbs, R. E.; Bellono, N.
10.1101/2025.03.03.641191 — physiology — Posted on 2025-03-04
4933 Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes
Rosko, J.; Cremin, K.; Locatelli, E.; Poon, R. N.; Coates, M.; Duxbury, S. J. N.; Randall, K.; Croft, K.; Valeriani, C.; Polin, M.; Soyer, O. S.
10.1101/2024.02.06.579126 — biophysics — Posted on 2025-03-04
4934 Metapipeline-DNA: A Comprehensive Germline & Somatic Genomics Nextflow Pipeline
Patel, Y.; Zhu, C.; Yamaguchi, T. N.; Wang, N.; Wiltsie, N.; Zeltser, N.; Gonzalez, A.; Winata, H.; Pan, Y.; Mootor, M. F. E.; Sanders, T.; Fitz-Gibbon, S. T.; Kandoth, C.; Livingstone, J.; Liu, L. Y.; Carlin, B.; Holmes, A.; Oh, J.; Sahrmann, J.; Tao, S.; Eng, S.; Hugh-White, R.; Pashminehazar, K.; Park, A.; Beshlikyan, A.; Jordan, M.; Wu, S.; Tian, M.; Arbet, J.; Neilsen, B.; Haas, R.; Bugh, Y. Z.; Kim, G.; Salmingo, J.; Zhang, W.; Anand, A.; Hwang, E.; Neiman-Golden, A.; Steinberg, P.; Zhao, W.; Anand, P.; Agrawal, R.; Tsai, B. L.; Boutros, P. C.
10.1101/2024.09.04.611267 — bioinformatics — Posted on 2025-03-04
4935 Pathlength-selective, interferometric diffuse correlation spectroscopy
Robinson, M. B.; Renna, M.; Otic, N.; Franceschini, M. A.; Carp, S. A.
10.1101/2024.06.21.600096 — bioengineering — Posted on 2025-03-04
4940 SSR42 is a Novel Regulator of Cytolytic Activity in Staphylococcus aureus
Jobson, M.-E.; Tomlinson, B. R.; Mustor, E. M.; Felton, E. A.; Weiss, A.; Caswell, C. C.; Shaw, L. N.
10.1101/2024.07.11.603084 — microbiology — Posted on 2025-03-04
4941 Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung
Yabaji, S. M.; Lata, S.; Tseng, A. E.; Araveti, P. B.; Lo, M.; Gavrish, I.; O'Connel, A. K.; Gertje, H. P.; Belkina, A.; Thurman, C. E.; Kiyokawa, H.; Kotton, D. N.; Tan, S.; Endsley, J. J.; Bishai, W. R.; Crossland, N.; Kobzik, L.; Kramnik, I.
10.1101/2023.10.17.562695 — immunology — Posted on 2025-03-04
4942 Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet
Ahn, S. J.; Goya, B.; Bertomo, C.; Sciortino, R.; Racchumi, G.; Garcia-Bonilla, L.; Anrather, J.; Iadecola, C.; Faraco, G.
10.1101/2025.02.27.640593 — neuroscience — Posted on 2025-03-04
4946 INTERPRETABLE MACHINE LEARNING UNVEILS KEY PREDICTORS AND DEFAULT VALUES IN AN EXPANDED DATABASE OF HUMAN IN VITRO DERMAL ABSORPTION STUDIES WITH PESTICIDES
Sarti, D. A.; Wagner, J.; Palma, F.; Kalvan, H.; Giachini, M. F.; Lautenschalaeger, D.; Lupianhez, V.; Pires, J. C.; Sales, M.; de Faria, P. M.; Bertomeu, L. C.; Le Bras, M.
10.1101/2023.05.11.540395 — pharmacology and toxicology — Posted on 2025-03-04
4947 PHLOWER - Single cell trajectory analysis using Decomposition of the Hodge Laplacian
Cheng, M.; Jansen, J.; Reimer, K.; Grande, V.; Nagai, J. S.; Li, Z.; Kiessling, P.; Grasshoff, M.; Kuppe, C.; Schaub, M.; Kramann, R.; Gesteira Costa Filho, I.
10.1101/2024.10.01.613179 — bioinformatics — Posted on 2025-03-04
4948 Fluorescent protein tags for human tropomyosin isoform comparison
Scott, W.; Polutranko, V.; Hands-Portman, I.; Balasubramanian, M. K.
10.1101/2025.02.25.640032 — cell biology — Posted on 2025-03-04
4949 Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
Buglino, J.; Ozakman, Y.; Hatch, C. E.; Benjamin, A.; Tan, D. S.; Glickman, M.
10.1101/2024.04.12.589290 — microbiology — Posted on 2025-03-04
4950 Miniaturized Workflow for Transcriptomic Profiling of Urinary Extracellular RNA during Pregnancy
Srinivasan, S.; De Hoff, P.; Morey, A. L.; Vuppala, A.; Mochizuki, M.; Morey, R. E.; Meads, M.; Duggan, E.; Wildman, D. E.; Nolan, J. P.; Pantham, P.
10.1101/2025.03.03.639539 — genetics — Posted on 2025-03-04
4951 Lutzomyia longipalpis salivary proteins elicit human innate and adaptive immune responses detrimental to Leishmania parasites
Abdeladhim, M.; Teixeira, C.; Ressner, R.; Hummer, K.; Dey, R.; Gomes, R.; de Castro, W.; de Araujo, F. F.; Turiansky, G. W.; Iniguez, E.; Meneses, C.; Oliveira, F.; Aronson, N.; Lacsina, J. R.; Valenzuela, J. G.; Kamhawi, S.
10.1101/2025.02.25.640210 — immunology — Posted on 2025-03-04
4952 Spatial Flux Balance Analysis reveals region-specific cancer metabolic rewiring and metastatic mimicking
Maspero, D.; Marteletto, G.; Lapi, F.; Galuzzi, B. G.; Ruano, I.; Vandenbosch, B.; Yin, K.; Tejpar, S.; Graudenzi, A.; Heyn, H.; Pascual-Reguant, A.; Damiani, C.
10.1101/2024.11.28.625842 — systems biology — Posted on 2025-03-04
4953 Neoplastic immune mimicry potentiates breast tumor progression
Berens, E. B.; Khou, S.; Huang, E.; Hoffman, A.; Johnson, B.; Kirchberger, N.; Sivagnanam, S.; Calistri, N. L.; Derrick, D.; Liby, T. A.; McLean, I. C.; Alanizi, A. A.; Ozmen, F.; Ozmen, T. Y.; Mills, G. B.; Hwang, E. S.; Schedin, P. J.; Gonzalez, H.; Werb, Z.; Heiser, L. M.; Coussens, L. M.
10.1101/2025.01.17.633673 — cancer biology — Posted on 2025-03-04
4954 Phospholipid esters from herring roe promotes SPM biosynthesis in human monocyte-derived macrophages and a keratinocyte/fibroblast co-culture with implications for the treatment of psoriasis
Ringheim-Bakka, T. A.; Saliani, A.; Ostbye, T.-K. K.; Mildenberger, J.; Dooley, M.; Busygina, M.; Pedersen, M. E.; Solberg, N. T.; Dalli, J.; Gammelsaeter, R.
10.1101/2025.02.20.639253 — biochemistry — Posted on 2025-03-04
4955 scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type-specific transcriptome-wide association study framework
Zhou, Y.; Adeluwa, T.; Zhu, L.; Salazar, S.; Sumner, S.; Kim, H.; Gona, S.; Nyasimi, F.; Kulkarni, R.; Powell, J.; Madduri, R.; Liu, B.; Chen, M.; Im, H. K.
10.1101/2024.11.11.623049 — genetics — Posted on 2025-03-04
4957 Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain
Gao, Y.; Tillu, V.; Wu, Y.; Rae, J.; Hall, T. E.; Chen, K.-E.; Weeratunga, S.; Guo, Q.; Livingstone, E.; Tham, W.-H.; Parton, R. G.; Collins, B. M.
10.1101/2024.11.26.625551 — cell biology — Posted on 2025-03-04
4958 Diffusion-based size determination of solute particles: a method adapted for PSD proteins
Szabo, A. L.; Nagy-Kanta, E.; Jager, E. A.; Pongor, C. I.; Laki, M.; Laki, A. J.; Gaspari, Z.
10.1101/2025.02.05.636588 — molecular biology — Posted on 2025-03-04
4959 Symbiont loss and gain, rather than co-diversification shapes honeybee gut microbiota diversity and function
Prasad, A.; Pallujam, A. D.; Siddaganga, R.; Suryanarayanan, A.; Mazel, F.; Brockmann, A.; Yek, S. H.; Engel, P.
10.1101/2024.09.11.612390 — microbiology — Posted on 2025-03-04
4960 Alterations in retinal tau phosphorylation in Alzheimer's disease patients identified by mass spectrometry
Santiago, J.; Poceviciute, D.; Vogel, J.; The Netherlands Brain Bank, ; Brinkmalm, G.; Wennstrom, M.
10.1101/2025.02.17.638688 — neuroscience — Posted on 2025-03-04
4961 Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K. L.; Doric, Z.; Haddad, D.; Mamaligas, A.; Liao, S.-C.; Creed, R.; Kano, K.; Chatterton, Z.; Fu, Y.; Garcia, J. H.; Vance, V.; Sei, Y.; Kreitzer, A.; Halliday, G.; Nelson, A.; Margolis, E.; Nakamura, K. L.
10.1101/2024.04.05.588321 — neuroscience — Posted on 2025-03-04
4963 Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction
Krogsaeter, E. K.; McKetney, J.; Valiente-Banuet, L.; Marquez, A.; Willis, A.; Cakir, Z.; Stevenson, E.; Jang, G. M.; Rao, A.; Li, E.; Zhou, A.; Attili, A.; Chang, T. S.; Kampmann, M.; Huang, Y.; Krogan, N. J.; Swaney, D. L.
10.1101/2023.10.02.560519 — neuroscience — Posted on 2025-03-04
4965 Arabidopsis PIEZO integrates magnetic field and blue light signaling to regulate root growth
Peng, Z.; Yang, W.; Dong, M.; Bai, H.; Lei, Y.; Pan, N.; Xie, Y.; Guo, L.; Liu, C.; Du, Y.
10.1101/2025.02.11.637623 — plant biology — Posted on 2025-03-04
4967 Deep Learning-Enhanced 3D Imaging Unveils Semaglutide Impact on Cardiac Fibrosis
Barrado-Ballestero, S.; Yttergren, S. T.; Hahn, M.; Rosenkilde, M. B.; Jensen, D. M.; Christensen, M.; Thisted, L.; Holmberg, H. L.; Teixeira, G.; Biering-Soerensen, T.; Salinas, C. G.; Roostalu, U.
10.1101/2025.02.25.640039 — pathology — Posted on 2025-03-04
4968 Hierarchical Lineage Tracing Reveals Diverse Pathways of AML Treatment Resistance
Saxe, R.; Stuart, H.; Marshall, A.; Abdullahi, F.; Chen, Z.; Emiliani, F.; McKenna, A.
10.1101/2025.02.27.640600 — cancer biology — Posted on 2025-03-04
4971 Accurate plasmid reconstruction from metagenomics data using assembly-alignment graphs and contrastive learning
Piera Lindez, P.; Danielsen, L. S.; Kovacic, I.; Pielies Avelli, M.; Nesme, J.; Jensen, L. J.; Nissen, J. N.; Sorensen, S. J.; Rasmussen, S.
10.1101/2025.02.26.640269 — bioinformatics — Posted on 2025-03-04
4972 A foundation language model to decipher diverse regulation of RNAs
Zhou, H.; Hu, Y.; Zheng, Y.; Li, J.; Peng, J.; Hu, J.; Yang, Y.; Zhang, G.; Wang, Z.
10.1101/2024.10.12.617732 — bioinformatics — Posted on 2025-03-04
4974 iKraph: a comprehensive, high-quality biomedical knowledge graph for AI-powered, data-driven biomedical research
Zhang, Y.; Pan, F.; Sui, X.; Yu, K.; Li, K.; Tian, S.; Erdengasileng, A.; Han, Q.; Wang, W.; Wang, J.; Wang, J.; Sun, D.; Chung, H.; Zhou, J.; Zhou, E.; Lee, B.; Zhang, P.; Qiu, X.; Zhao, T.; Zhang, J.
10.1101/2023.10.13.562216 — bioinformatics — Posted on 2025-03-04
4976 Preventing peritendinous adhesions using lubricious supramolecular hydrogels
Meany, E.; Williams, C. M.; Song, Y. E.; Doulames, V. M.; Bailey, S. J.; Williams, S. C.; Jons, C. K.; Fox, P.; Appel, E.
10.1101/2025.02.22.639655 — bioengineering — Posted on 2025-03-04
4977 A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modelling potential
Sarnowski, C. P.; Knörlein, A.; de Vries, T.; Götze, M.; Beusch, I.; Aebersold, R.; Allain, F. H.- T.; Hall, J.; Leitner, A.
10.1101/2022.03.31.486537 — biochemistry — Posted on 2025-03-04
4978 Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes
Hakala, M.; Moparthi, S. B.; Ganeva, I.; Gul, M.; Espadas, J.; Marcuello, C.; Bernat-Silvestre, C.; Colom, A.; Kudryashev, M.; Kukulski, W.; Vassilopoulos, S.; Kaksonen, M.; Roux, A.
10.1101/2024.10.01.616068 — biochemistry — Posted on 2025-03-04
4980 Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy
Dong, G.; Ma, C. C.; Mao, S.; Naik, S. M.; Brown, K. S.-M.; McDonough, G. A.; Kim, J.; Kirkham, S. L.; Cherry, J.; Uretsky, M.; Spurlock, E.; McKee, A.; Huang, A. Y.; Miller, M. B.; Lee, E. A.; Walsh, C. A.
10.1101/2025.03.03.641217 — genomics — Posted on 2025-03-04
4981 A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction
Vrindavan Manian, K.; Ludwig, C. H.; Zhao, Y.; Abell, N. S.; Yang, X.; Root, D. E.; Albert, M. L.; Comander, J.
10.1101/2025.02.27.640335 — genomics — Posted on 2025-03-04
4984 The physiological costs of leadership in collective movements
Brandl, H. B.; Klarevas-Irby, J. A.; Zuniga, D.; Wheat, C. H.; Christensen, C.; Omengo, F.; Nzomo, C.; Cherono, W.; Nyaguthii, B.; Farine, D. R.
10.1101/2023.11.22.567987 — ecology — Posted on 2025-03-04
4989 Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages
Ma, S.; Yang, B.; Sun, Y.; Wang, X.; Guo, H.; Liu, R.; Ye, T.; Kang, C.; Chen, J.; Jiang, L.
10.1101/2024.10.07.616983 — microbiology — Posted on 2025-03-04
4991 Molecular and cellular signatures differentiate Parkinson's disease from Parkinson's disease with dementia
Fairbrother-Browne, A.; Grant-Peters, M.; Brenton, J. W.; Nelvagal, H.; Reynolds, R. H.; Lim, Y. M.; Gustavsson, E. K.; Macpherson, H.; Montgomery, K.; Evans, J. R.; Hicks, A. R.; Chiraki, N.; Curless, T.; Real, R.; Xenakis, T.; Houlden, H.; Morris, H. R.; Gandhi, S.; Wood, N. W.; Hardy, J.; Jaunmuktane, Z.; Ryten, M.
10.1101/2025.03.04.641379 — neuroscience — Posted on 2025-03-04
4992 Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity
Gupta, H. P.; Azevedo, A.; Chen, Y.-C. D.; Xing, K.; Sims, P. A.; Varol, E.; Mann, R.
10.1101/2025.03.04.640006 — neuroscience — Posted on 2025-03-04
4993 Multimodal optical imaging and modulation through Smart Dura in non-human primates
Hong, N.; Vargo, S. M.; Hatanaka, G.; Gong, Z.; Stanis, N.; Zhou, J.; Belloir, T.; Wang, R. K.; Bair, W.; Chamanzar, M.; Yazdan-Shahmorad, A.
10.1101/2025.02.27.640384 — neuroscience — Posted on 2025-03-04
4995 Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans
Maslarova, A.; Shin, J. N.; Navas-Olive, A.; Voroslakos, M.; Hamer, H.; Doerfler, A.; Henin, S.; Buzsaki, G.; Liu, A.
10.1101/2025.02.06.636758 — neuroscience — Posted on 2025-03-04
4996 MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation
Kline, E. M.; Jernigan, J. E.; Scharer, C. D.; Maurer, J.; Hicks, S. L.; Herrick, M. K.; Wallings, R. L.; Kelly, S. D.; Chang, J.; Menees, K. B.; McFarland, N. R.; Boss, J. M.; Tansey, M. G.; Joers, V.
10.1101/2024.08.31.610581 — neuroscience — Posted on 2025-03-04
5001 Multiplex-edited mice recapitulate woolly mammoth hair phenotypes
Chen, R.; Srirattana, K.; Coquelin, M. L.; Vilar Sampaio, R.; Wilson, R.; Ganji, R.; Weston, J.; Ledesma, A.; Beebe, J.; Sullivan, J.; Qin, Y.; Chao, J. C.; Papizan, J.; Mastracci, A.; Bhide, K.; Mathews, J.; Oglesby, R.; Menon, M.; van der Valk, T.; Bow, A.; Cantarel, B. L.; James, M.; Kehler, J.; Dalen, L.; Lamm, B.; Church, G. M.; Shapiro, B.; Abrams, M. E.
10.1101/2025.03.03.641227 — genetics — Posted on 2025-03-04
5002 Multi-drug tolerance in Leishmania persister-like cells
Aroni-Soto, A. M.; Monsieurs, P.; Goovaerts, O.; Choukri, K.; Khanal, B.; Adriaensen, W.; Dujardin, J.-C.; Barrett, M. P.; Domagalska, M. A.
10.1101/2025.03.03.641139 — microbiology — Posted on 2025-03-04
5003 Responses of neurons in macaque V4 to object and texture images
Lieber, J. D.; Oleskiw, T. D.; Palmieri, L.; Simoncelli, E. P.; Movshon, J. A.
10.1101/2024.02.20.581273 — neuroscience — Posted on 2025-03-04
5004 Infectious Bronchitis: Molecular Detection and Characterization in Live Bird Markets in Jos, Plateau State, Nigeria
Inuwa, B.; Musa, H. I.; Hambali, I. U.; Tijjani, A. O.; Adamu, S. G.; Sadiq, M. A.; Shittu, I.; Meseko, C.
10.1101/2025.03.02.641078 — microbiology — Posted on 2025-03-04
5005 Genome-wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Borrego-Yaniz, G.; Marquez, A.; Estupinan-Moreno, E.; Terron-Camero, L. C.; Gonzalez-Gay, M. A.; Castaneda, S.; Guggino, G.; Saadoun, D.; Lio, P.; Fontana, S.; Bonacini, M.; Rossi, A.; Cavazza, A.; Muratore, F.; Salvarani, C.; Pipitone, N.; Martin, J.; Croci, S.; Ortiz-Fernandez, L.
10.1101/2025.02.27.640503 — immunology — Posted on 2025-03-04
5007 A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer
Kroehling, L.; Chen, A.; Spinella, A.; Reed, E.; Kukuruzinska, M.; Varelas, X.; Monti, S.
10.1101/2025.03.02.640812 — cancer biology — Posted on 2025-03-04
5008 Fractal and Machine Learning analyses of MALDI-TOF Mass Spectrometry data in glioblastoma
Lazari, L. C.; Azemi, G.; Russo, C.; Fernandes, L. R.; Marie, S. K. N.; Di Ieva, A. C.; Palmisano, G.
10.1101/2025.03.03.641183 — bioinformatics — Posted on 2025-03-04
5010 Single-cell copy number alteration signature analysis reveals masked patterns and potential biomarkers for cancer
wu, c.; tao, z.; Chen, W.; Wang, N.; Wang, J.; Wu, T.; Qiu, D.; Diao, K.; Zhao, X.; Lu, T.; Zhang, L.; Wang, W.; Li, X.; Li, X.; Xiong, X.; Liu, X.-S.
10.1101/2025.03.02.641098 — genomics — Posted on 2025-03-04
5013 RHOA Loss of Function Impairs the IFNγ Response and Promotes CD19 Antigen Escape to Drive CAR-T Resistance in Diffuse Large B-cell Lymphoma
Newsam, A. D.; Ziccheddu, B.; Gowda Saralamma, V. V.; Coughlin, C. A.; Goretsky, Y. E.; Youssfi, A. A.; Russo, M. V.; Campos Gallego, N.; Fattakhov, N.; Coffey, D. G.; Tsai, D. E.; Carmona-Berrio, D.; Suissa, D. M.; Manara, P.; Sondhi, A. K.; Roberts, E. R.; Sheffield-Veney, I.; Spiegel, J. Y.; Amador, C.; Alderuccio, J. P.; Bilbao, D.; Jain, M. D.; Maura, F.; Locke, F. L.; Schatz, J. H.
10.1101/2025.02.27.640687 — cancer biology — Posted on 2025-03-04
5014 Granular component sub-phases direct ribosome biogenesis in the nucleolus
Dogra, P.; Ferrolino, M. C.; Khatun, S.; Tolbert, M.; Miao, Q.; Pruett-Miller, S. M.; Pitre, A.; Tripathi, S.; Campbell, G. E.; Bajpai, R.; Freyaldenhoven, T.; Gibbs, E.; Park, C.-G.; Kriwacki, R. W.
10.1101/2025.03.01.640913 — biochemistry — Posted on 2025-03-04
5015 Public perception of dog emotional and motivational states in videos: A cross-sectional analysis
Samet, L. E.; Muschinski, J.; Harvey, N. D.; Giragosian, K.; Upjohn, M.; Murray, J.; Owczarczak-Garstecka, S.
10.1101/2025.02.28.640863 — animal behavior and cognition — Posted on 2025-03-04
5016 Transcriptomic changes across subregions of the primate cerebellum support the evolution of uniquely human behaviors
Rickelton, K.; Ely, J. J.; Hopkins, W. D.; Hof, P. R.; Sherwood, C. C.; Bauernfeind, A. L.; Babbitt, C. C.
10.1101/2025.03.03.641249 — genomics — Posted on 2025-03-04
5018 The Caenorhabditis elegans spe-21 gene that encodes a palmitoyltransferase is necessary for spermiogenesis.
Suryanarayanan, S.; Chen, D. S.; Zuo, Y.; Gleason, E. J.; Zhu, Z.; L'Hernault, S. W.; Krauchunas, A. R.; Singson, A.
10.1101/2025.03.03.641263 — developmental biology — Posted on 2025-03-03
5021 A Single-Cell Woodchuck Liver Atlas Identifies Healthy and Disease-Related Cellular Programs Conserved in Human
Clarke, Z. A.; Atif, J.; Wang, X.; Liu, L. Y.; Wood, L.; Camat, D.; Chung, S.; Ma,, X.-Z.; Manuel, J.; Lok, S.; Lau, T.; Thoeni, C.; Michalak, T. I.; McGilvray, I. D.; Bader, G. D.; MacParland, S. A.
10.1101/2025.03.03.641192 — cell biology — Posted on 2025-03-03
5022 Redefining human pre-rRNA processing at single nucleotide resolution using long read Nanopore sequencing
Pastore, S.; Wacheul, L.; Lehmann, L.; Muendnich, S.; Lutz, B.; Helm, M.; Gerber, S.; Lafontaine, D. L.; Butto, T.
10.1101/2025.03.01.640970 — cell biology — Posted on 2025-03-03
5023 Lysine Potentiates Insulin Secretion via AASS-Dependent Catabolism and Regulation of GABA Content and Signaling
Munoz, F.; Gao, Q.; Mattanovich, M.; Trost, K.; Hodek, O.; Lindqvist, A.; Wierup, N.; Fex, M.; Moritz, T.; Mulder, H.; Cataldo, L. R.
10.1101/2025.03.03.641187 — cell biology — Posted on 2025-03-03
5025 Label-Free Quantification of Apoptosis and Necrosis Using Stimulated Raman Scattering Microscopy
Mahapatra, S.; Shivpuje, S. B.; Campbell, H. C.; Wan, B.; Lomont, J.; Dong, B.; Ma, S.; Mohn, K. J.; Zhang, C.
10.1101/2025.03.01.641010 — cell biology — Posted on 2025-03-03
5026 Laminar Architecture of a Decision Circuit in Orbitofrontal Cortex
Livi, A.; Zhang, M.; Carter, M.; Schoknecht, H.; Burkhalter, A.; Holy, T. E.; Padoa-Schioppa, C.
10.1101/2025.03.03.641234 — neuroscience — Posted on 2025-03-04
5028 Oxytocin and Dopamine Receptor Expression: Cellular Level Implications for Pair Bonding
Loth, M. K.; Schmidt, J. C.; Gonzalez, C. A.; Brusman, L. E.; Sadino, J. M.; Winther, K. E.; Protter, D. S.; Donaldson, Z. R.
10.1101/2025.03.03.640889 — neuroscience — Posted on 2025-03-04
5029 Neural representation of action symbols in primate frontal cortex
Tian, L. Y.; Garzon, K. U.; Rouse, A. G.; Eldridge, M. A.; Schieber, M. H.; Wang, X.-J.; Tenenbaum, J. B.; Freiwald, W. A.
10.1101/2025.03.03.641276 — neuroscience — Posted on 2025-03-04
5031 Effects of altered gravity on adrenergic-mediated cAMP signalling in intact cells
Bathe-Peters, M.; Sohail, I.; Sirbu, A.; Schneider, K.; Patriarchi, T.; De Lanerolle, P.; Annibale, P.
10.1101/2025.03.02.640942 — cell biology — Posted on 2025-03-03
5038 Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2
Schrecker, M.; Son, Y.; Planells-Cases, R.; Kar, S.; Vorobeva, V.; Schulte, U.; Fakler, B.; Jentsch, T. J.; Hite, R. K.
10.1101/2025.02.28.640562 — cell biology — Posted on 2025-03-03
5039 Discovery of a novel flagellar filament system underpinning Leishmania adhesion to surfaces
Owino, B. O.; Yanase, R.; Marron, A. O.; Moreira-Leite, F.; Vaughan, S.; Sunter, J. D.
10.1101/2025.03.03.641248 — cell biology — Posted on 2025-03-03
5040 P4-ATPase control over phosphoinositide membrane asymmetry and neomycin resistance
Jain, B. K.; Duan, H. D.; Valentine, C.; Samiha, A.; Li, H.; Graham, T. R.
10.1101/2025.03.03.641220 — cell biology — Posted on 2025-03-03
5041 Visualizing homology search in living cells
Friskes, A.; Snoek, M.; Oldenkamp, R.; van den Broekb.vd., B.; Nahidiazar, L.; Koob, L.; Dick, A. E.; Mertz, M.; Harkes, R.; Rowland, B. D.; Jalink, K.; Medema, R. H.
10.1101/2025.03.01.640932 — cell biology — Posted on 2025-03-03
5042 Methylation-Based Deconvolution Unveils Glioblastoma Heterogeneity and Cell-Type Composition Linked to Patient Survival
Iluz, A.; Lavi, N.; Charbit, H.; Gutreiman, M.; Idelson, M.; Steiner, D.; Ben-Shushan, E.; Zick, A.; Eden, A.; Mordechai, A.; Moscovici, S.; Fellig, Y.; Lossos, A.; Moss, J.; Reubinoff, B. E.; Lavon, I.
10.1101/2025.02.27.640603 — cancer biology — Posted on 2025-03-03
5043 DeepSeMS: a large language model reveals hidden biosynthetic potential of the global ocean microbiome
Xu, T.; Yang, Y.; Zhu, R.; Lin, W.; Li, J.; Zheng, Y.; Zhang, P.; Zhang, G.; Zhao, G.-P.; Jiao, N.
10.1101/2025.03.02.641084 — synthetic biology — Posted on 2025-03-03
5044 Engineering gene drive docking sites in a haplolethal locus in Anopheles gambiae
Smidler, A. L.; Marrogi, E. A.; Scott, S.; Mameli, E.; Abernathy, D.; Akbari, O. S.; Church, G. M.; Catteruccia, F. L.; Esvelt, K. M.
10.1101/2025.03.03.641265 — synthetic biology — Posted on 2025-03-03
5045 Magnetic resonance control of reaction yields through genetically-encoded protein:flavin spin-correlated radicals in a live animal
Burd, S. C.; Bagheri, N.; Ingaramo, M.; Condon, A. F.; Mondal, S.; Dowlatshahi, D. P.; Summers, J. A.; Mukherjee, S.; York, A. G.; Wakatsuki, S.; Boxer, S. G.; Kasevich, M.
10.1101/2025.02.27.640669 — biophysics — Posted on 2025-03-03
5048 Restoration of ovarian endocrine function with encapsulated immune isolated human ovarian xenograft in ovariectomized mice
Brunette, M.; Wall, M.; Sinko, D.; Machlin, J.; Blevins, G.; Leo, M.; Ta, A.; Ray, B.; Cascalho, M.; Padmanabhan, V.; Shikanov, A.
10.1101/2025.02.27.640622 — bioengineering — Posted on 2025-03-03
5050 Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
Fraguas Bringas, C.; Ahangar, M. S.; Cuenco, J.; Liu, H.; Addinsall, A. B.; Lindahl, M.; Foretz, M.; Göransson, O.; Scott, J. W.; Zeqiraj, E.; Sakamoto, K.
10.1101/2025.02.28.640688 — biochemistry — Posted on 2025-03-03
5051 Temperature influences West Nile virus evolution and adaptation
Fay, R. L.; Cruz-Loya, M.; Maffei, J. G.; Mordecai, E. A.; Ciota, A. T.
10.1101/2025.02.28.640855 — molecular biology — Posted on 2025-03-03
5054 EVOFLOW-RNA: GENERATING AND REPRESENTING NON-CODING RNA WITH A LANGUAGE MODEL
Patel, S.; Peng, F. Z.; Fraser, K.; Friedman, A. D.; Chatterjee, P.; Yao, S.
10.1101/2025.02.25.639942 — synthetic biology — Posted on 2025-03-03
5057 Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotype
Behrendt, A.; Bastianelli, A.; Stindt, J.; Pfister, E.-D.; Sgodda, M.; Cantz, T.; Hook, S.; Grau, K.; Brands, S.; Droege, C.; Stalke, A.; Bonus, M.; Franke, S.; Baumann, U.; Keitel, V.; Gohlke, H.
10.1101/2024.02.08.579530 — physiology — Posted on 2025-03-03
5058 Hierarchical Lineage Tracing Reveals Diverse Pathways of AML Treatment Resistance
Saxe, R.; Stuart, H.; Marshall, A.; Abdullahi, F.; Chen, Z.; Emiliani, F.; McKenna, A.
10.1101/2025.02.27.640600 — cancer biology — Posted on 2025-03-03
5059 Cellular Responses to Photothermal Therapy: Heat-Induced ERK Signaling and Intercellular Communication in Solid Tumors
Taemaitree, F.; Takano, Y.; Yamaguchi, D.; Yamaguchi, K.; Yamashita, Y.; Tsutsumi, M.; Wen, C.; Otomo, K.; Hirai, K.; Hutchison, J. A.; Van Zundert, I.; Krzyzowska, S.; Bravo, M.; Hirano, S.; Kimura, K. D.; Aoki, K.; Rocha, S.; Nemoto, T.; Fortuni, B.; Uji-i, H.
10.1101/2025.02.27.640541 — cancer biology — Posted on 2025-03-03
5065 TRF2 Non-Telomeric Function is Indispensable for Neural stemness
Vinayagamurthy, S.; Bhatt, A. K.; Bagri, S.; Ghosh, S.; Parichha, A.; Maitra, A.; Chowdhury, S.
10.1101/2025.02.28.640739 — molecular biology — Posted on 2025-03-03
5066 ANIDULAFUNGIN AND HUMAN MONOCYTES REDUCE Candida spp. BIOFILM WITH DIFFERENT FUNGAL BIOMASS.
Icely, P. A.; Angiolini, S. C.; Rodriguez, E.; Vigezzi, C.; Paiva, C.; Miro, M. S.; Abiega, C. D.; Caeiro, J. P.; Riera, F.; Sotomayor, C. E.
10.1101/2025.03.03.641158 — microbiology — Posted on 2025-03-03
5067 A reliable in vitro rumen culture system and workflow for screening anti-methanogenic compounds
Laric, P. P.; Mortazavi, A.; Wegrzyn, E.; Simon, K.; Rittel, P. S.; Trefz, F. M.; Sabass, B.
10.1101/2025.03.03.641173 — microbiology — Posted on 2025-03-03
5068 Early pandemic HIV-1 integration site preferences differ across anatomical reservoirs
Kohio, H. P.; Ajoge, H. O.; Barua, E. A.; Vajaria, N. R.; Wu, I. K. F.; Coleman, M. D.; Tom, S. K.; van der Meer, F.; Gill, J.; Church, D.; Beck, P. L.; Power, C.; van Marle, G.; Barr, S. D.
10.1101/2025.03.03.641190 — microbiology — Posted on 2025-03-03
5069 Spatiotemporal Dynamics of the Dihydrolipoyl Dehydrogenase LpdA Determine the Intrinsic Autofluorescence in Filamentous Actinobacteria
Iliasov, D.; Santander Gualdron, R.; Loerzing, P.; Maass, S.; Cinar, B.; Wollenhaupt, B.; Kohlheyer, D.; Becher, D.; Loderer, C.; Tschowri, N.; Schlierf, M.; Zaburdaev, V.; Mascher, T.
10.1101/2025.03.03.640617 — microbiology — Posted on 2025-03-03
5070 Molecular characterization and pathogenicity assessment of bacteria causing infectious diseases in cage-farmed fish in the Lake Victoria
Ndaro, M. E.; Saiperaki, J. L.; Rumisha, c.; Funga, A.; Mwang'onde, B. J.; Mzula, A.; Materu, S. F.; Mwakosya, C. A.
10.1101/2025.03.02.641053 — microbiology — Posted on 2025-03-03
5072 Multi-drug tolerance in Leishmania persister-like cells
Aroni-Soto, A. M.; Monsieurs, P.; Goovaerts, O.; Choukri, K.; Khanal, B.; Adriaensen, W.; Dujardin, J.-C.; Barrett, M. P.; Domagalska, M. A.
10.1101/2025.03.03.641139 — microbiology — Posted on 2025-03-03
5073 Interrogating the genus Yersinia to define the rules of lipopolysaccharide lipid A structure associated with pathogenicity.
Fernandez-Carrasco, M. H.; Dahlstrom, K. M.; Calderon-Gonzalez, R.; Dumigan, A.; Marzinek, J. K.; Lancaster, R.; Bond, P. J.; Salminen, T. A.; Bengoechea, J. A.
10.1101/2025.03.03.641127 — microbiology — Posted on 2025-03-03
5078 Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure
Latorre-Crespo, E.; Robertson, N. A.; Kosebent, G.; Macgillivray, L.; Murphy, L.; Uddin, M.; Honigberg, M.; Whitsel, E. A.; Bick, A. G.; Reiner, A. P.; Orru, V.; Marongiu, M.; Cucca, F.; Fiorillo, E.; Deary, I.; Harris, S.; Cox, S. R.; Marioni, R.; Schumacher, L.; Chandra, T.; Kirschner, K.
10.1101/2025.02.28.640879 — genetics — Posted on 2025-03-03
5080 Dynamic allelic expression in mouse mammary gland across the adult developmental cycle
Hanin, G.; Costello, K. R.; Tavares, H.; Alsulaiti, B.; Patel, S.; Edwards, C. A.; Ferguson-Smith, A. C.
10.1101/2024.09.02.610775 — developmental biology — Posted on 2025-03-03
5081 Jade1 and the HBO1 complex are spatial-selective cofactors of Oct4
Wu, Y.; Manna, A. K.; Li, L.; Handa, H.; Chandrasekharan, M. B.; Tantin, D.
10.1101/2024.11.07.622531 — molecular biology — Posted on 2025-03-03
5082 A modular platform to display multiple hemagglutinin subtypes on a single immunogen
Lamson, D. T.; Mohamed, F. A. N.; Vu, M.; Maurer, D. P.; Ronsard, L.; Lingwood, D.; Schmidt, A. G.
10.1101/2023.11.09.566478 — immunology — Posted on 2025-03-03
5083 Prdm16-dependent antigen-presenting cells induce tolerance to intestinal antigens
Fu, L.; Upadhyay, R.; Pokrovskii, M.; Chen, F. M.; Romero-Meza, G.; Griesemer, A.; Littman, D. R.
10.1101/2024.07.23.604803 — immunology — Posted on 2025-03-03
5087 Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma
Yates, J.; Mathey-Andrews, C.; Park, J.; Garza, A.; Gagne, A.; Hoffman, S. E.; Bi, K.; Titchen, B.; Hennessey, C.; Remland, J.; Shannon, E. E.; Camp, S.; Balamurali, S.; Kiran Cavale, S.; Li, Z.; Kishore Raghawan, A.; Kraft, A.; Boland, G.; Aguirre, A. J.; Sethi, N.; Boeva, V.; Van Allen, E.
10.1101/2024.08.17.608386 — cancer biology — Posted on 2025-03-03
5088 Interplay between cytokine and FGF2 signaling in induction of entosis and vasculogenic mimicry response in glioblastoma
Kang, T.-Y.; Park, J.; Dincer, A.; Baskaran, J.; Ren, C.; Scuderi, S.; Yang, L.; McGuone, D.; Miller-Jensen, K.; Gunel, J. M.; Gunel, M.; Levchenko, A.
10.1101/2025.02.09.637275 — cancer biology — Posted on 2025-03-03
5090 NOTCH1 drives tumor plasticity and metastasis in hepatocellular carcinoma
Lindblad, K. E.; Donne, R.; Liebling, I.; Bresnahan, E.; Barcena-Varela, M.; Lozano, A.; Park, E.; Giotti, B.; Burn, O.; Fiel, M. I.; Alsinet, C.; Monga, S. P.; Xue, R.; Bravo-Cordero, J. J.; Tsankov, A. M.; Lujambio, A.
10.1101/2024.10.23.619856 — cancer biology — Posted on 2025-03-03
5091 Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC
Chang-Gonzalez, A. C.; Akitsu, A.; Mallis, R. J.; Lang, M. J.; Reinherz, E. L.; Hwang, W.
10.1101/2024.10.16.618634 — biophysics — Posted on 2025-03-03
5092 Helical foldamers as selective G-quadruplex ligands
Koenig, A.; Laffile, V.; Thore, S.; Mackereth, C. D.; Yatsunyk, L.; Ferrand, Y.; Largy, E.; Gabelica, V.
10.1101/2025.02.25.640101 — biophysics — Posted on 2025-03-03
5098 Nanopore Long-Read Sequencing Unveils Genomic Disruptions in Alzheimer's Disease
Ramirez, P.; Sun, W.; Kazempour Dehkordi, S.; Zare, H.; Pascarella, G.; Carninci, P.; Fongang, B.; Bieniek, K. F.; Frost, B.
10.1101/2024.02.01.578450 — genomics — Posted on 2025-03-03
5099 A human induced pluripotent stem cell toolbox for studying sex chromosome effects
Meleckyte, R.; Varsally, W.; Zohren, J.; Eriksson, J.; Incitti, T.; Starnes, L.; Pointon, A.; Hicks, R.; Powell, B. E.; Turner, J.
10.1101/2025.02.28.640277 — genetics — Posted on 2025-03-03
5104 Competition for microtubule lattice spacing between a microtubule expander and compactor.
Paquette, A. L.; Cruz Tetlalmatzi, S.; Haineault, J. A. G.; Hendricks, A. G.; Brouhard, G. J.; Sebastien, M.
10.1101/2025.02.28.640185 — cell biology — Posted on 2025-03-03
5105 A prophage-encoded anti-phage defense system that prevents phage DNA packaging by targeting the terminase complex
Azulay, G.; Sigal, N.; Tzohar Rabinovich, K.; Koenigsfeld, D.; Stadnyuk, O.; Das, A.; Lisitzin, P.; Biderman, E.; Borovok, I.; Herskovits, A. A.
10.1101/2025.02.27.640495 — microbiology — Posted on 2025-03-03
5106 Structure of the turnip yellows virus particles: How is the readthrough domain exposed on the capsid surface?
Lai-Kee-Him, J.; Trapani, S.; Boissinot, S.; Reinbold, C.; Fallet, C.; Ancelin, A.; Lecorre, F.; Hoh, F.; Ziegler-Graff, V.; Brault, V.; Bron, P.
10.1101/2024.10.14.617924 — microbiology — Posted on 2025-03-03
5108 Increased Callosal Thickness in Early Trained Opera Singers
Kleber, B.; Dale, C.; Zamorano, A. M.; Lotze, M.; Luders, E.; Kurth, F.
10.1101/2025.02.28.640273 — neuroscience — Posted on 2025-03-03
5109 Expression of Fibroblast Growth Factor Receptor 3 (FGFR3) in the Human Peripheral Nervous System: Implications for the Putative Pathogenic Role of FGFR3 Autoantibodies in Neuropathy
Chamessian, A.; Tavares-Ferreira, D.; Payne, M.; Govindarajan, R.; Pestronk, A.; Bertels, Z.; Slivicki, R. A.; Del Rosario, J. S.; Yi, J.; Copits, B. A.; Ornitz, D.; Price, T. J.; Gereau, R. J.
10.1101/2025.03.03.639509 — neuroscience — Posted on 2025-03-03
5110 Absence seizures and sleep-wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder
Hristova, K.; Fasol, M. C.; McLaughlin, N.; Nawaz, S.; Taskiran, M.; Buller-Peralta, I.; Bassi, A.; Ocampo-Garces, A.; Escudero, J.; Kind, P. C.; Gonzalez-Sulser, A.
10.1101/2024.02.27.582289 — neuroscience — Posted on 2025-03-03
5112 Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
Sharif, A.; Jeffers, M. S.; Fergusson, D. A.; Bapuji, R.; Nicholls, S. G.; Humphrey, J.; Johnston, W.; Mitchell, E.; Speirs, M.-A.; Stronghill, L.; Vuckovic, M.; Wulf, S.; Shorr, R.; Dowlatshahi, D.; Corbett, D.; Lalu, M. M.
10.1101/2024.09.25.614925 — neuroscience — Posted on 2025-03-03
5114 The genetic basis for synchronized time perception in plant populations
Lock, S. C. L.; McCarthy, K.; Ronald, J.; Anwer, M. U.; Davis, A.; Hallstein, M.; Redmond, E. J.; Knight, M.; Davis, S.; Ezer, D.
10.1101/2025.02.25.640030 — plant biology — Posted on 2025-03-03
5116 Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma
Hancock, S. E.; Garthwaite, L.; Harellis, K.; Susetio, M.; Ding, E.; Choong, L.; Contreras, O.; Nguyen, A.; Lising, J.; Hansen, F. K.; Wongsomboon, P.; Menzel, J. P.; Poad, B. L.; Mitchell, T. W.; Blanksby, S. J.; Turner, N.
10.1101/2024.12.18.628624 — cancer biology — Posted on 2025-03-03
5118 Targeting CD38 effectively prevents myelofibrosis in myeloproliferative neoplasms
Yan, Y.; Liu, J.; Zhao, S.; Li, F.; Yang, L.; Xu, Z.; Qin, T.; Zhu, X.; An, W.; Huang, G.; Rampal, R. K.; Xiao, Z.; Li, B.
10.1101/2025.03.02.639410 — cancer biology — Posted on 2025-03-03
5119 An engineered platform to study the influence of extracellular matrix nanotopography on cell ultrastructure
Tcherner Elad, S.; Vilensky, R.; Ben Asher, N.; Logvina, N.; Zalk, R.; Zussman, E.; Engel, L.
10.1101/2025.02.27.640302 — biophysics — Posted on 2025-03-03
5120 Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Cappello, G.; Wodrascka, F.; Marquez-Vivas, G.; Radwan, A. E.; Anoop, P.; Mascheroni, P.; Fouchard, J.; Fabry, B.; Ambrosi, D. C.; Recho, P.; de Beco, S.; Balland, M.; Boudou, T.
10.1101/2025.02.25.640067 — biophysics — Posted on 2025-03-03
5122 Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson's disease: from rodent models to non-human primates
Batts, A. J.; Ji, R.; Bae, S.; Tsitsos, F. N.; Jimenez-Gambin, S.; Kwon, N.; Gorman, S. L.; Tsakri, D.; Noel, R. L.; Bendig, J.; Jimenez, D. A.; DiBenedetto, M.; Del Castillo, S. A.; Keleta, F. B.; Caicedo, J.; Romanov, A.; Curley, C. T.; Dzhashiashvili, Y.; Walton-Gibbs, G. D.; Hollidge, B. S.; Przedborski, S.; Ramsburg, E.; Danos, O.; Ferrera, V. P.; Engel, E. A.; Smith, J. B.; Konofagou, E. E.
10.1101/2025.03.02.639893 — bioengineering — Posted on 2025-03-03
5123 Artificial Intelligence for automatic movement recognition: a network-based approach
Troisi Lopez, E.; Minino, R.; De luca, M.; Tafuri, F.; Sorrentino, G.; Sorrentino, P.; Corsi, M.-C.
10.1101/2025.02.27.640538 — bioengineering — Posted on 2025-03-03
5124 Machine Learning applied to MALDI-TOF data in a clinical setting: a systematic review
Schmidt-Santiago, L.; Guerrero-Lopez, A.; Sevilla-Salcedo, C.; Rodriguez-Temporal, D.; Rodriguez-Sanchez, B.; Gomez-Verdejo, V.
10.1101/2025.01.25.634879 — bioengineering — Posted on 2025-03-03
5125 Development of a Genetically Encoded Live-Cell Iron Mapping System
Akyol, A.; Cimen, S.; Gottschalk, B.; Alston, A. B.; Digigow, R.; Flühmann, B.; Eroglu, E.; Graier, W. F.; Malli, R.
10.1101/2025.02.25.639876 — biochemistry — Posted on 2025-03-03
5127 Single-cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease
Urbanski, G.; Taylor, K. E.; Flynn, E.; Norouzi, A.; Chu, C.; Davidson, B.; Ghosh, A.; Nititham, J.; Patel, R. K.; Poon, A. W.; Fragiadakis, G. K.; Combes, A. K.; Eckalbar, W. L.; Criswell, L. A.; Ye, C. J.; Shiboski, C. H.
10.1101/2025.02.27.640483 — genomics — Posted on 2025-03-03
5130 Subtropical anticyclone impacts life-history traits of a marine top predator
SUN, R.; Rouby, E.; Weimerskirch, H.; Barbraud, C.; Delord, K. C.; Ummenhofer, C.; Jenouvrier, S.
10.1101/2025.02.27.640559 — ecology — Posted on 2025-03-03
5131 Loss of characteristic species across German federal states detected by repeated mapping of protected habitats
Luettgert, L.; Heisterkamp, S.; Jansen, F.; Kaufmann, R.; Kellner, S.; Klenke, R. A.; Luett, S.; Seidler, G.; Wedler, A.; Woermann, R.; Bruelheide, H.
10.1101/2025.02.27.640325 — ecology — Posted on 2025-03-03
5133 A lncRNA-mediated metabolic rewiring of cell senescence
Grossi, E.; Marchese, F. P.; Gonzalez, J.; Goni, E.; Fernandez-Justel, J. M.; Amadoz, A.; Herranz, N.; Puchades-Carrasco, L.; Montes, M.; Huarte, M.
10.1101/2024.01.25.577153 — cell biology — Posted on 2025-03-03
5134 Induction and long-term maintenance of hindbrain-like neural stem cells in xeno- and basic fibroblast growth factor-free conditions
Al-Akashi, Z.; Zujur, D.; Boyd-Gibbins, N.; Wiguna, N. E.; Nakagawa, M.; Kikuchi, T.; Morizane, A.; Takahashi, J.; Ikeya, M.
10.1101/2025.03.03.640169 — cell biology — Posted on 2025-03-03
5137 Longitudinal analysis of antibody titers after primary and booster mRNA COVID-19 vaccination can identify individuals at risk for breakthrough infection
Park, H.; Nakamura, N.; Miyamoto, S.; Sato, Y.; Kim, K. S.; Kitagawa, K.; Kobashi, Y.; Tani, Y.; Shimazu, Y.; Zhao, T.; Nishikawa, Y.; Omata, F.; Kawashima, M.; Abe, T.; Saito, Y.; Nonaka, S.; Takita, M.; Yamamoto, C.; Morioka, H.; Kato, K.; Sagou, K.; Yagi, T.; Kawamura, T.; Sugiyama, A.; Nakayama, A.; Kaneko, Y.; Shibata, R. Y.; Aihara, K.; Kodama, T.; Kamiyama, A.; Tamura, T.; Fukuhara, T.; Shibuya, K.; Suzuki, T.; Iwami, S.; Tsubokura, M.
10.1101/2025.03.01.639360 — immunology — Posted on 2025-03-03
5138 Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage
Mpotje, T.; Rajkumar-Bhugeloo, K.; Moodley, D.; Nargan, K.; Lawrence, T. K.; Fisher, K. L.; Maepa, S. W.; Thambu, K.; Lumamba, K.; Majozi, P.; Rapulana, A. M.; Parihar, S. P.; Naidoo, T.; Madansein, R.; Ndlovu, H.; Leslie, A.; Gordon, S.; Steyn, A.; Marakalala, M. J.
10.1101/2025.02.27.640170 — immunology — Posted on 2025-03-03
5140 A correlative workflow streamlines synaptic imaging by cryo-electron tomography
Do, T. T.; Siegert, A.; Domart, F.; Hahn, F.; Zeising, C.; Muth, S. M.; Pape, C.; Kusch, K.; Dresbach, T.; Rizzoli, S.; Petrovic, A.; Fernandez-Busnadiego, R.
10.1101/2025.03.01.640558 — neuroscience — Posted on 2025-03-03
5143 How many mammal species are there now? Updates and trends in taxonomic, nomenclatural, and geographic knowledge.
Burgin, C. J.; Zijlstra, J. S.; Becker, M. A.; Handika, H.; Alston, J. M.; Widness, J.; Liphardt, S.; Huckaby, D. G.; Upham, N. S.
10.1101/2025.02.27.640393 — zoology — Posted on 2025-03-03
5144 Ethylene modulates cell wall mechanics for root responses to compaction
Zhang, J.; Qu, Z.; Liu, Z.; Li, J.; Farrar, E.; Chara, O.; Ogorek, L. P.; Borges, A.; Sakamoto, S.; Mitsuda, N.; Zhu, X.; Zhu, M.; Shi, J.; Liang, W.; Bennett, M.; Pandey, B.; Zhang, D.; Persson, S.
10.1101/2025.03.02.640043 — plant biology — Posted on 2025-03-03
5146 Intracameral Puncture Lowers Intraocular Pressure and Triggers an Immune Response in the Conventional Outflow Tract
Schuman, D. M.; Suarez, M. F.; Grimsrud, A. O.; Kuhn, M.; Saban, D. R.; Stamer, W. D.; Liu, K. C.
10.1101/2025.03.03.639599 — physiology — Posted on 2025-03-03
5148 ATF4-Mediated Metabolic Stress Response as a Therapeutic Vulnerability in Chordoma
Cottone, L.; Dunford, J. P.; Calcutt, E.; Gamble, V.; Aksu, F. S.; Ligammari, L.; Gaeta, G.; Christianson, J. C.; Flanagan, A. M.; Oppermann, U.; Cribbs, A. P.
10.1101/2025.02.27.640253 — cancer biology — Posted on 2025-03-03
5152 Zinc-finger proteins with a co-opted capsid domain anchor nucleosomes over transposon sequences
Matsushima, W.; Duc, J.; Sheppard, S.; Pulver, C.; Grun, D.; Offner, S.; Raclot, C.; Planet, E.; Trono, D.
10.1101/2025.03.03.638093 — genetics — Posted on 2025-03-03
5154 The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels
Sabbioni, S.; Filippone, M. G.; Amadori, L.; Confalonieri, S.; Bonfanti, R.; Capoano, S.; Colaluca, I. N.; Freddi, S.; Bertalot, G.; Faga, G.; Zagarri, E.; Varasi, M.; Gunby, R. H.; Mercurio, C.; Pece, S.; Di Fiore, P. P.; Tosoni, D.
10.1101/2025.02.27.640530 — cancer biology — Posted on 2025-03-03
5155 Comparative analysis of human and mouse ovaries across age
Gaylord, E. A.; Foecke, M. F.; Samuel, R. M.; Soygur, B.; Detweiler, A. M.; Dorman, L.; Borja, M.; Laird, A. E.; Arjyal, R.; Du, J.; Gardner, J. M.; Neff, N.; Fattahi, F.; Laird, D. J.
10.1101/2025.02.27.640481 — genomics — Posted on 2025-03-03
5156 Sarcomeric Remodelling in Human Heart Failure unraveled by single molecule long read sequencing
Haas, J.; Schudy, S.; Rauscher, B.; Munoz, A.; Rosskopf, S.; Reich, C.; Doenmez Yalcin, G.; Yalcin, A.; Seeger, T.; Taft, M.; Freichel, M.; Grimm, D.; Manstein, D. J.; Backs, J.; Frey, N.; Steinmetz, L. M.; Meder, B.
10.1101/2025.02.28.640805 — genetics — Posted on 2025-03-03
5157 Colorectal Cancer-Associated Streptococcus gallolyticus: A Hidden Diversity Exposed
Perichon, B.; COKELAER, T.; TEH, W. K.; du Merle, L.; Ma, L.; Doloy, A.; Poyart, C.; Givskov, M.; Trieu-Cuot, P.; Dramsi, S.
10.1101/2025.02.28.640884 — microbiology — Posted on 2025-03-03
5160 Potato Late Blight Control with a Botanical Product and Reduced Copper Applications
Musa, T.; Kagi, A.; Gutlin, H.; Schnee, S.; Massana-Codina, J.; Sullam, K. E.
10.1101/2025.01.08.627882 — plant biology — Posted on 2025-03-03
5161 KDM5 demethylases suppress R-loop-mediated viral mimicry and DNA damage in breast cancer cells
Lau, L.; Henderson, K.; Turkoz, A.; Linker, S.; Schlessinger, D.; Townsley, B.; Egan, B.; Ragunathan, S.; Rollins, R.; Bi, X.; Chen, Z. J.; Brodsky, O.; Restaino, C.; Murali, G.; Jensen-Pergakes, K.; Maaarstig, A.; Kermi, C.; Moore, P.; Classon, M.
10.1101/2025.02.26.640279 — cancer biology — Posted on 2025-03-03
5162 Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies
Talucci, I.; Leske, T.; Klafki, H.-W.; Hassan, M. M.; Steiert, A.; Morgado, B.; Bothe, S.; van Werven, L.; Liepold, T.; Walter, J.; Schindelin, H.; Wiltfang, J.; Wirths, O.; Jahn, O.; Maric, H. M.
10.1101/2025.02.26.640323 — biochemistry — Posted on 2025-03-03
5163 Distinct chromatin regulators downmodulate meiotic axis formation and DNA break induction at chromosome ends
Raghavan, A. R.; May, K.; Subramanian, V. V.; Blitzblau, H. G.; Patel, N. J.; Houseley, J.; Hochwagen, A.
10.1101/2025.02.27.640173 — genetics — Posted on 2025-03-03
5164 Using fisheries risk assessment to inform precautionary and collaborative management in a declining coho salmon fishery
Wilson, K. L.; Atlas, W. I.; Whitney, C. K.; Reid, M.; Service, C. N.; Connors, B. M.; Adams, M. S.
10.1101/2025.02.26.640431 — ecology — Posted on 2025-03-03
5166 Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer
Kakati, R. T.; Whitman, A. A.; Haase, S.; Szenasi, A. T.; Thai, C. H.; Brunk, E. C.; Okumu, D. O.; East, M. P.; Perou, C. M.; Johnson, G. L.; Spanheimer, P. M.
10.1101/2024.12.19.629395 — cancer biology — Posted on 2025-03-03
5170 Astrocytic RNA editing regulates the host immune response to alpha-synuclein
D'Sa, K.; Choi, M. L.; Wagen, A. Z.; Seto-Salvia, N.; Kopach, O.; Evans, J. R.; Rodrigues, M.; Lopez-Garcia, P.; Lachica, J.; Singh, J.; Ghareeb, A.; Bayne, J.; Grant-Peters, M.; Garcia-Ruiz, S.; Chen, Z.; Rodriques, S.; Athauda, D.; Gustavsson, E. K.; Gagliano Taliun, S. A.; Toomey, C.; Reynolds, R. H.; Young, G.; Strohbuecker, S.; Warner, T.; Rusakov, D. A.; Patani, R.; Bryant, C.; Klenerman, D. A.; Gandhi, S.; Ryten, M.
10.1101/2024.02.26.582055 — neuroscience — Posted on 2025-03-03
5173 Parallel gene expression changes in ventral midbrain dopamine and GABA neurons during normal aging
Drumond-Bock, A. L.; Blankenship, H. E.; Pham, K. D.; Carter, K. A.; Freeman, W. M.; Beckstead, M. J.
10.1101/2025.02.28.640868 — neuroscience — Posted on 2025-03-03
5177 Hierarchical Patterns of Soil Nematode Biodiversity in the Atacama Desert: Insights Across Biological Scales
Villegas, L.; Pettrich, L.; Acevedo-Trejos, E.; Suwanngam, A.; Wassey, N.; Allende, M. L.; Stoll, A.; Holovachov, O.; Waldvogel, A.-M.; Schiffer, P. H.
10.1101/2024.09.30.615889 — ecology — Posted on 2025-03-02
5179 Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI
Spencer, A. P. C.; Nguyen-Duc, J.; de Riedmatten, I.; Szczepankiewicz, F.; Jelescu, I. O.
10.1101/2024.10.01.615823 — neuroscience — Posted on 2025-03-02
5180 Modeling Organoid Population Electrophysiology Dynamics
Roos, M. J.; Luna, D.; El Din, D.-M. A.; Hartung, T.; Smirnova, L.; Proescher, A.; Johnson, E. C.
10.1101/2025.03.02.641081 — neuroscience — Posted on 2025-03-02
5182 sCentInDB: A database of essential oil chemical profiles of Indian medicinal plants
Baskaran, S. P.; Ranganathan, G.; Sahoo, A. K.; Kumar, K.; Amaresan, J.; Ramesh, K.; Vivek-Ananth, R. P.; Samal, A.
10.1101/2025.02.24.639916 — pharmacology and toxicology — Posted on 2025-03-02
5183 Evaluation of Aggregate Oral Fluid Sampling for Early Detection of African Swine Fever Virus Infection
Faburay, B.; O'Hara, K.; Remmenga, M.; Odoom, T.; Johnson, S.; Tasiame, W.; Ayim-Akonor, M.; Anderson, B.; Amoake, K.; Holder, D.; Ping, W.; Zajac, M.; O'Donnell, V.; Xu, L.; Holland, R.; Levings, R.; Brown, C.; Robbe-Austerman, S.
10.1101/2025.02.19.638111 — microbiology — Posted on 2025-03-02
5184 Protocol for Developing a Mouse Model of Post Primary Pulmonary Tuberculosis after Hematogenous Spread in Native Lungs and Lung Implants
Yabaji, S. M.; Lata, S.; Gavrish, I.; Lo, M.; O Connell, A. K.; Gertje, H. P.; Thurman, C. E.; Crossland, N. A.; Kobzik, L.; Kramnik, I.
10.1101/2025.02.28.640830 — immunology — Posted on 2025-03-02
5185 Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathies
Saunders, C. R.; Rocha-Rangel, P. V.; Desai, R.; Quadri, Z.; Liu, H.; Hunt, J. B.; Huimin, L.; Rogers, C. B.; Nash, K.; Tsoi, P. S.; Abner, E. L.; Ferreon, A. C.; Ferreon, J. C.; Norris, C.; Uversky, V. N.; Nelson, P. T.; Cramer, J.; Chaput, D.; Lee, D. C.; Selenica, M.-L. B.
10.1101/2025.02.28.639952 — neuroscience — Posted on 2025-03-02
5186 Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure
Latorre-Crespo, E.; Robertson, N. A.; Kosebent, G.; Macgillivray, L.; Murphy, L.; Uddin, M.; Honigberg, M.; Whitsel, E. A.; Bick, A. G.; Reiner, A. P.; Orru, V.; Marongiu, M.; Cucca, F.; Fiorillo, E.; Deary, I.; Harris, S.; Cox, S. R.; Marioni, R.; Schumacher, L.; Chandra, T.; Kirschner, K.
10.1101/2025.02.28.640879 — genetics — Posted on 2025-03-02
5191 Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells
Azeroglu, B.; Wu, W.; Pavani, R.; Sandhu, R.; Matsumoto, T.; Nussenzweig, A.; Lazzerini Denchi, E.
10.1101/2025.02.27.640565 — molecular biology — Posted on 2025-03-02
5192 Retinol Binding Protein 4 reactivates latent HIV-1 via the JAK/STAT5 and JNK pathways
Pastorio, C.; Richard, K.; Hayn, M.; Koepke, L.; Preising, A.; Preising, N.; Staendker, L.; Fair, M.; Morris, J.; Papasavvas, E.; Sun, H.; Rodriguez, A.; Mounzer, K. C.; Wiese, S.; Tebas, P.; Du, Y.; Laird, G. M.; Sparrer, K. M.; Montaner, L. J.; Kirchhoff, F.
10.1101/2025.02.26.640366 — immunology — Posted on 2025-03-02
5195 Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium
Emin, M. T.; Dubuisson, A. M.; Sujin Kumar, P.; Knutsen, C.; Alvira, C. M.; Hough, R. F.
10.1101/2025.02.26.640349 — physiology — Posted on 2025-03-02
5199 Harp: Platform Independent Deconvolution Tool
Nozari, Z.; Huettl, P.; Simeth, J.; Schoen, M.; Hutchinson, J. A.; Spang, R.
10.1101/2025.02.26.640330 — bioinformatics — Posted on 2025-03-02
5204 S'Wipe: User-Friendly Stool Collection for High-Throughput Gut Metabolomics
Moradi, D.; Lotfi, A.; Melnik, A. V.; Pobozhev, K.; Monahan, H.; Kopylova, E.; Zhou, Y.; Aksenov, A. A.
10.1101/2025.02.27.640581 — biochemistry — Posted on 2025-03-02
5206 An ancient lysozyme in placozoans participates in acidic extracellular digestion
Berndt, H.; Duarte, I.; Repnik, U.; Struwe, M.; Abukhalaf, M.; Scheidig, A.; Tholey, A.; Gruber-Vodicka, H.; Leippe, M.
10.1101/2024.10.06.616844 — evolutionary biology — Posted on 2025-03-02
5208 Genetic evidence: zebrafish hoxba and hoxbb clusters are essential for the anterior-posterior positioning of pectoral fins
Kikuchi, M.; Fujii, R.; Kobayashi, D.; Kawabe, Y.; Kanno, H.; Toyama, S.; Tawakkal, F.; Yamada, K.; Kawamura, A.
10.1101/2025.02.03.636262 — developmental biology — Posted on 2025-03-02
5210 Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics
Helekal, D.; Mortimer, T. D.; Mukherjee, A.; Gentile, G.; Le Van, A.; Nicholas, R. A.; Jerse, A. E.; Palace, S. G.; Grad, Y. H.
10.1101/2025.02.03.636319 — microbiology — Posted on 2025-03-02
5212 Hallmarks and metabolic regulation of type 2 activated human lung macrophages
Ridley, A. J. L.; Curle, A. J.; Colombo, S. A. P.; Hughes, J. J.; Dyer, D. P.; Simpson, A.; Feeney, M.; Cook, P. C.; MacDonald, A. S.
10.1101/2025.02.26.640352 — immunology — Posted on 2025-03-02
5213 CCR7 Expression Distinguishes Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity
Soon, M. S.; Oyong, D. A.; Dooley, N.; Mukhiya, R.; Pava, Z.; Andrew, D.; Loughland, J. R.; McCarthy, J.; Chan, J.-A.; Beeson, J. G.; Engwerda, C.; Haque, A.; Boyle, M. J.
10.1101/2025.02.27.640479 — immunology — Posted on 2025-03-02
5214 Different isolates of Leishmania aethiopica elicit distinct effector functions in primary human monocytes
Cruz Cervera, E.; Adem, E.; Yizengaw, E.; Takele, Y.; Müller, I.; Cotton, J. A.; Kropf, P.
10.1101/2025.02.26.640320 — immunology — Posted on 2025-03-02
5215 Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction
Sid, H.; von Heyl, T.; Schleibinger, S.; Klinger, R.; Heyemelot Nabel, L.; Vikkula, H. K.; Guabiraba, R.; Guillory, V.; Alhussien, M. M.; Boehm, B.; Schade, B.; Elleder, D.; Sives, S.; Vervelde, L.; Trapp, S.; Schusser, B.
10.1101/2023.11.01.564710 — immunology — Posted on 2025-03-02
5217 Mouse helpers ensure maternal-infant survival
Schuster, L.; Ivan, V.; Suarez, D. M. G.; Henderson, R.; Caslin, A.; Minder, J.; Kaur, G.; Sankar, S.; Ananth, D.; Kirk, M.; Winokur, S.; Khatri, L.; Leone, P.; Adolph, K. E.; Froemke, R. C.; Mar, A.
10.1101/2022.12.26.521927 — neuroscience — Posted on 2025-03-02
5218 Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Castranio, E. L.; Varghese, M.; Argyrousi, E. K.; Tripathi, K.; Soderberg, L.; Bresnahan, E.; Lerner, D.; Garretti, F.; Zhang, H.; van de Loo, J.; Stimpson, C.; Talty, R.; Glabe, C.; Levy, E.; Wang, M.; Ilkov, M.; Zhang, B.; Lannfelt, L.; Guerin, B.; Lubell, W. D.; Rahimipour, S.; Dickstein, D. L.; Gandy, S. E.; Arancio, O.; Ehrlich, M. E.
10.1101/2025.02.25.639746 — neuroscience — Posted on 2025-03-02
5219 Global Distribution of Coronaviruses among Bat Populations detected using Molecular techniques, A Systematic Review
Mulemena, J. A.; Sichamba, P.; Muleya, W.; Mubemba, B.; Chitanga, S.; Simulundu, E.; Changula, K.
10.1101/2025.03.01.640975 — zoology — Posted on 2025-03-02
5222 Changes in motor unit conduction velocity after unilateral lower limb suspension and active recovery correlate with muscle ion channel gene expression
Valli, G.; Sarto, F.; Negro, F.; Monti, E.; Sirago, G.; Paganini, M.; Zampieri, S.; Franchi, M. V.; Casolo, A.; Candia, J.; Ferrucci, L.; Narici, M. V.; De Vito, G.
10.1101/2025.02.26.640329 — physiology — Posted on 2025-03-02
5224 Single-cell profiling of human bone marrow reveals multiple myeloma progression is accompanied by an increase in CD56bright bone marrow resident NK cells.
Rees, E.; Sodi, I.; Foster, K.; Ainley, L.; Lyon, E.; Galas-Filipowicz, D.; Rahman, J.; Allen, R.; Kimber, J.; Prabu, A.; Ward, G.; Jankovic, D.; Laidler, A.; Hudson-Lund, B.; Chavda, S.; Lecat, C.; Hughes, D.; Rashid, A.; Vallance, G.; Bygrave, C.; Smith, D.; Al-Kaisi, F.; Willis, F.; Parrish, C.; Lee, L.; Ramasamy, K.; Colucci, F.; Boyle, E. M.; Yong, K.
10.1101/2025.02.26.640356 — cancer biology — Posted on 2025-03-02
5225 Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity
Yao, H.; Song, Y.; Huang, Q.; Zhu, M.; Liang, J.; Zhang, Z.; Zhang, X.; Dong, D.; Shi, D.; Wu, Z.; Lu, X.; Wu, H.; Chen, Y.; Li, S.
10.1101/2025.02.28.640788 — biophysics — Posted on 2025-03-02
5229 Rapid delivery of RNase H1 enables replication fork progression under stress independently of R-loop resolution
Basille, A.; Lin, Y.-L.; Kirke, C.; Cluet, D.; Bawadi, Y.; Vachez, L.; Dervieux, V.; Guiguettaz, L.; Bernard, P.; Hamperl, S.; Pasero, P.; Ricci, E. P.; Vanoosthuyse, V.
10.1101/2025.02.27.640516 — molecular biology — Posted on 2025-03-02
5232 Salmonella effector kinase SteC is activated by host-mediated phosphorylation
Pillay, T. D.; Lemetais, B.; Huber, J.; Diaz Del Olmo, I.; Li, Y.; Masino, L.; Maslen, S.; Liu, M.; Esposito, D.; Hinton, J. C. D.; Yu, X.-J.; Thurston, T. L. M.; Rittinger, K.
10.1101/2025.03.01.640964 — microbiology — Posted on 2025-03-02
5233 Rational design of next-generation filovirus vaccines with glycoprotein stabilization, nanoparticle display, and glycan modification
Lee, Y.-Z.; Zhang, Y.-N.; Newby, M. L.; Ward, G.; Gomes, K. B.; Auclair, S.; DesRoberts, C.; Allen, J.; Ward, A. D.; Stanfield, R.; He, L.; Crispin, M.; Wilson, I. A.; Zhu, J.
10.1101/2025.03.02.641072 — microbiology — Posted on 2025-03-02
5237 Phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages
Cheng, H. Y.; Chu, J.; Limjunyawong, N.; Chen, J.; Ye, Y.; Chen, K. H.; Koylass, N.; Sun, S.; Dong, X.; Qiu, Z.
10.1101/2025.02.27.640612 — immunology — Posted on 2025-03-02
5241 The VelB intrinsically disordered domain promotes selective heterodimer formation of velvet domain regulatory proteins for fungal development
Koehler, A. M.; Thieme, S.; Gerke, J.; Thieme, K.; Harting, R.; Schmitt, K.; Valerius, O.; Chen, W.; Hoefer, A.; Bastakis, E.; Strohdiek, A.; Heinrich, A.; Bode, H.; Braus, G. H.
10.1101/2025.02.27.640524 — molecular biology — Posted on 2025-03-02
5243 Amphetamine in Adolescence Induces a Sex-Specific Mesolimbic Dopamine Phenotype in the Adult Prefrontal Cortex
Hernandez, G.; Zhao, J.; Niu, Z.; MacGowan, D.; Capolicchio, T.; Song, A.; Gul, S.; Moiz, A.; Herrera, I.; Day, J. J.; Flores, C.
10.1101/2025.02.26.640363 — neuroscience — Posted on 2025-03-02
5245 Chill tolerant Drosophila species maintain electrogenic muscle membrane potential to resist cold-induced depolarization
Overgaard, J.; Bayley, J. S.; Poulsen, J. N.; Jensen, N. J. S.; Pedersen, T. H.; Herskind, J.; Andersen, M. K.
10.1101/2025.02.26.640316 — physiology — Posted on 2025-03-02
5246 Precise metabolic dependencies of cancer through deep learning and validations
Tao, W.; Xiangyu, Z.; Yu, Z.; Die, Q.; Kaixuan, D.; Dongliang, X.; Weiliang, W.; Xiaopeng, X.; Xinxiang, L.; Xue-Song, L.
10.1101/2025.02.26.640327 — cancer biology — Posted on 2025-03-02
5248 SIMPROV : Provenance capturing for simulation studies
Ruscheinski, A.; Wolpers, A.; Henning, P.; Wilsdorf, P.; Uhrmacher, A. M.
10.1101/2025.02.26.640288 — bioinformatics — Posted on 2025-03-02
5249 Deep learning guided design of protease substrates
Martin Alonso, M. C.; Alamdari, S.; Samad, T. S.; Yang, K. K.; Bhatia, S. N.; Amini, A. P.
10.1101/2025.02.27.640681 — biochemistry — Posted on 2025-03-02
5251 Epigenome and interactome profiling uncovers principles of distal regulation in the barley genome
Navratilova, P.; Pavlu, S.; Zhu, Z.; Tulpova, Z.; Kopecky, O.; Novak, P.; Stein, N.; Simkova, H.
10.1101/2025.02.27.640517 — genomics — Posted on 2025-03-02
5252 SyFi: generating and using sequence fingerprints to distinguish SynCom isolates
Selten, G.; Gomez Repolles, A.; Lamouche, F.; Radutoiu, S.; de Jonge, R.
10.1101/2025.02.27.640502 — genomics — Posted on 2025-03-02
5259 Repulsive interactions instruct synaptic partner matching in an olfactory circuit
Li, Z.; Lyu, C.; Xu, C.; Hu, Y.; Luginbuhl, D. J.; Caspi-Lebovic, A. B.; Priest, J. M.; Özkan, E.; Luo, L.
10.1101/2025.03.01.640985 — neuroscience — Posted on 2025-03-02
5261 Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction
Reineke, L. C.; Zhu, P. J.; Dalwadi, U.; Dooling, S. W.; Liu, Y.; Wang, I.-C.; Young-Baird, S.; Okoh, J.; Kuncha, S. K.; Zhou, H.; Kannan, A.; Park, H.; Debeaubien, N. A.; Croll, T.; Lee, D. J.; Arthur, C.; Dever, T. E.; Walter, P.; Chen, J.; Frost, A.; Costa-Mattioli, M.
10.1101/2025.02.28.640897 — neuroscience — Posted on 2025-03-02
5265 Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia
Stewart, A. E.; Zachman, D. K.; Castellano-Escuder, P.; Kelly, L. M.; Zolyomi, B.; Aiduk, M. D. I.; Delaney, C. D.; Lock, I. C.; Bosc, C.; Bradley, J.; Killarney, S. T.; Ilkayeva, O. R.; Newgard, C. B.; Chandel, N. S.; Puissant, A.; Wood, K. C.; Hirschey, M. D.
10.1101/2025.02.26.640463 — cancer biology — Posted on 2025-03-02
5266 Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors
Nelen, I. H.; Leys, S.; Bekaert, S.-L.; De Vloed, F.; Martens, F.; Raj, A. P. E.; Ohmura, S.; Vleminckx, L.; Grunewald, T. G. P.; Van Roy, N.; De Wilde, B.; Speleman, F.; Van Hemelryk, A.; Depestel, L.; Durinck, K.
10.1101/2025.02.26.640375 — cancer biology — Posted on 2025-03-02
5267 SOX21 Suppresses Glioblastoma Growth by Repressing AP-1 Activity
Muhr, J.; Rrapaj, E.; Yuan, J.; Kurtsdotter, I.; Misyurin, V.; Baselli, G.; Persson, O.; Bergsland, M.
10.1101/2024.07.05.601643 — cancer biology — Posted on 2025-03-02
5268 BaGPipe: an automated, reproducible, and flexible pipeline for bacterial genome-wide association studies
Wei, K.; Blane, B.; Toussaint, J.; Reuter, S.; Toleman, M. S.; Torok, E.; Peacock, S. J.; Harrison, E. M.; Aggarwal, D.; Roberts-Sengier, W.
10.1101/2025.02.28.640835 — bioinformatics — Posted on 2025-03-02
5269 Unveiling Protein-DNA Interdependency: Harnessing Unified Multimodal Sequence Modeling, Understanding and Generation
Li, M.; Ren, Y.; Ye, P.; Cheng, J.; Ma, X.; Cai, Y.; Ouyang, W.; Zhong, B.; Wu, B.; Dong, N.; Hong, L.; Tan, P.
10.1101/2025.02.26.640480 — bioinformatics — Posted on 2025-03-02
5271 Woodsmoke and Diesel Exhaust: Distinct Transcriptomic Profiles in the Human Airway Epithelium
Huff, R. D.; Rider, C. F.; Lo, T.; Hardy, K. I.; El-Bittar, N.; Ryu, M. H.; Carlsten, C.; Lim, E. L.
10.1101/2025.02.26.640436 — bioinformatics — Posted on 2025-03-02
5273 Predicting PROTAC-targeted Degradation and Designing Androgen Receptor Degraders with AiPROTAC
Zhang, L.; Sun, R.; Li, X.; Ren, C.; Long, Y.; Tan, W.; Wang, X.; Zou, K.; Yang, X.; Wu, M.; Li, X.; Chen, X.
10.1101/2025.02.26.640266 — bioinformatics — Posted on 2025-03-02
5276 Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies
Williams, E. C.; Franzen, L.; Lindvall, M. O.; Hamm, G.; Oag, S.; Denholm, J.; Hamidinekoo, A.; Majumder, M. M.; Morlanes, J. E.; Vicari, M.; Lundeberg, J.; Setyo, L.; Zakirov, A.; Hornberg, J. J.; Stamou, M.; Stahl, P. L.; Ollerstam, A.; Tan, J.; Mohorianu, I.
10.1101/2025.02.26.640381 — bioinformatics — Posted on 2025-03-02
5282 Integrating Single-Molecule Sequencing and Deep Learning to Predict Haplotype-Specific 3D Chromatin Organization in a Mendelian Condition
Dubocanin, D.; Kalygina, A.; Franklin, J. M.; Chittenden, C.; Vollger, M. R.; Neph, S.; Stergachis, A. B.; Altemose, N.
10.1101/2025.02.26.640261 — genomics — Posted on 2025-03-02
5283 Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice
Bruno, M.; Maisha, S.; Mitra, A.; Costello, K. R.; Watkins-Chow, D. E.; Logsdon, G. A.; Gambogi, C. W.; Dumont, B. L.; Black, B. E.; Keane, T. M.; Ferguson-Smith, A. C.; Dale, R.; Macfarlan, T. S.
10.1101/2025.02.26.640358 — genetics — Posted on 2025-03-02
5284 Ablation of the evolutionarily acquired functions of the Atp1b4 gene in mice protects against obesity and increases metabolic capacity
Modyanov, N. N.; Russo, L.; Ghosh, S. L.; Castaneda, T.; Marathe, H.; Bourey, R. E.; Najjar, S. M.; de la Serna, I. L.
10.1101/2025.02.26.640446 — evolutionary biology — Posted on 2025-03-02
5285 Adaptive fitness in APC-mutant cells requires chromosome rearrangements
Kawasaki, Y.; Hamaji, T.; Owada, K.; Hayashi, A.; Wu, Y.; Nogi, T.; Okada, M.; Sakai, S.; Tokushige, N.; Sasagawa, S.; Nakagawa, H.; Kouyama, Y.; Niida, A.; Mimori, K.; Kuroda, T.; Senda, T.; Ohsugi, M.; Fumoto, K.; Kikuchi, A.; Widlund, P. O.; Kiyosue, K.; Yamashita, N.; Morita, M.; Yokota, H.; Arjunan, S. N. V.; Chew, W.-X.; Takahashi, K.; Legant, W. R.; Chen, B.-C.; Betzig, E.; Smits, R.; Fodde, R.; Oshima, H.; Oshima, M.; Taketo, M. M.; Akiyama, T.; Mimori-Kiyosue, Y.
10.1101/2020.09.18.303016 — cell biology — Posted on 2025-03-02
5287 Unraveling new characteristics of γδT cells using scRNA-seq in TCR KO chicken
von Heyl, T.; Brunner, M.; Schmauser, A.; Wurmser, C.; Frueh, S. P.; Schusser, B.
10.1101/2025.02.26.640441 — immunology — Posted on 2025-03-02
5289 Smart Dura: a functional artificial dura for multimodal neural recording and modulation
Montalvo Vargo, S. I.; Hong, N.; Belloir, T.; Stanis, N.; Zhou, J.; Khateeb, K.; Hatanaka, G.; Ahmed, Z.; Kimukin, I.; Griggs, D. J.; Bair, W.; Yazdan-Shahmorad, A.; Chamanzar, M.
10.1101/2025.02.26.640369 — neuroscience — Posted on 2025-03-02
5292 Examining Alzheimer's Disease Modifiable Risk Factors: Impact of Physical Activity and Diet on Neuroanatomy and Behaviour in Mice
Garcia, C. L.; Anastassiadis, C.; Urosevic, M.; Park, M.; Gallino, D.; Devenyi, G. A.; Yee, Y.; Chakravarty, M. M.
10.1101/2025.02.26.640411 — neuroscience — Posted on 2025-03-02
5293 Reduced harmonic complexity of brain parenchymal cardiovascular pulse waveforms in Alzheimer's disease
Koivula, A.; Perkiömäki, V.; Aho, M.; Rasila, A.; Poltojainen, V.; Korhonen, V.; Jarvela, M.; Huotari, N.; Helakari, H.; Tuunanen, J.; Raitamaa, L.; Väyrynen, T.; Krüger, J.; Kiviniemi, V.; Kananen, J.
10.1101/2025.02.26.640409 — neuroscience — Posted on 2025-03-02
5294 REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness
Mortazavi, N.; Talwar, P.; Koshmanova, E.; Sharifpour, R.; Beckers, E.; Berger, A.; Campbell, I.; Paparella, I.; Balda, F.; Dardour Hamzaoui, I.; Berthomier, C.; Bastin, C.; Phillips, C.; Maquet, P.; Collette, F.; Zubkov, M.; Lamalle, L.; Vandewalle, G.
10.1101/2024.07.12.603275 — neuroscience — Posted on 2025-03-02
5296 Role of NLRP3 activation in salt sensitive blood pressure regulation, effect of ND-13
Garcia, R.; Polzin, J.; Sanchez, C. A.; Guillen, E.; Latham, P.; De Miguel, C.; Ferranil, J.; Armando, I.; Jose, P.; Cuevas, S.
10.1101/2025.02.26.640392 — physiology — Posted on 2025-03-02
5301 QTL combinations associated with field partial resistance to aphanomyces root rot in pea Near-Isogenic Lines
LAVAUD, C.; RIVIERE, J.-P.; VETEL, P.; AUBERT, G.; MARGET, P.; ROULLET, G.; HERBOMMEZ, J.-F.; DECLERCK, P.; Pilet-Nayel, M.-L.
10.1101/2025.02.28.640773 — genetics — Posted on 2025-03-02
5302 Gearing up Golden Braid assembly for plant synthetic genomics with RepTiles
Petrova, V.; Andrejic, D.; Finkenrath, T.; Grewer, J.; Zurbriggen, M. D.; Urquiza-Garcia, U.
10.1101/2025.02.28.640145 — synthetic biology — Posted on 2025-03-02
5304 TMK interacting network of receptor like kinases for auxin canalization and beyond
Monzer, A.; Mazur, E.; Rodriguez, L.; Gallei, M.; Zou, M.; Smejkal, M.; Cervenov, E.; Friml, J.
10.1101/2025.02.28.640727 — plant biology — Posted on 2025-03-02
5305 Sequence-dependent shape and stiffness of DNA and RNA double helices: hexanucleotide scale and beyond
Slavnikova, P.; Cuker, M.; Matouskova, E.; Cmelo, I.; Zgarbova, M.; Jurecka, P.; Lankas, F.
10.1101/2025.02.27.640607 — biophysics — Posted on 2025-03-02
5307 Tubulin transforms Tau and -synuclein condensates from pathological to physiological
Lucas, L.; Tsoi, P. S.; Quan, M. D.; Choi, K.-J.; Ferreon, J. C.; Ferreon, A. C. M.
10.1101/2025.02.27.640500 — biophysics — Posted on 2025-03-02
5308 Coarse-grained chromatin dynamics by trackingmultiple similarly labeled gene loci
Mader, A.; Rodriguez, A. I.; Yuan, T.; Surovtsev, I. V.; King, M. C.; Mochrie, S. G. J.
10.1101/2025.02.27.640402 — biophysics — Posted on 2025-03-02
5312 Lipids Are Involved in Heterochromatin Condensation: A Quantitative Raman and Brillouin Microscopy Study
Machida, M.; Kajimoto, S.; Shibuya, R.; Isono, M.; Watabe, M.; Oma, Y.; Hibino, K.; Fujii, K.; Okumura, M.; Harata, M.; Shibata, A.; Nakabayashi, T.
10.1101/2025.02.26.640449 — biophysics — Posted on 2025-03-02
5315 Parallel mosaic speciation via mutation-order and ecological divergence
James, M. E.; Melo, M. C.; Roda, F.; Bernal-Franco, D. M.; Wilkinson, M. J.; Walter, G. M.; Liu, H.; Engelstaedter, J.; Ortiz-Barrientos, D.
10.1101/692673 — evolutionary biology — Posted on 2025-03-02
5316 Where do the Dmanisi hominins fit on the human evolutionary tree?
Argue, D.; Bermudez de Castro, J. M.; Lee, M. S. Y.; Martinon-Torres, M.
10.1101/2025.03.01.639363 — evolutionary biology — Posted on 2025-03-02
5318 Atypical functional connectome in congenitally blind humans
Koba, C.; Falco-Roget, J.; Collignon, O.; Raczy, K.; Bedny, M.; Tian, M.; Szwed, M.; Stroh, A.-L.
10.1101/2025.02.28.640746 — neuroscience — Posted on 2025-03-02
5319 Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics
Muralidharan, C.; Zakar-Polyak, E.; Adami, A.; Abbas, A. A.; Sharma, Y.; Garza, R.; Johansson, J. G.; Atacho, D. A. M.; Renner, E.; Palkovits, M.; Kerepesi, C.; Jakobsson, J.; Pircs, K.
10.1101/2025.02.28.640749 — neuroscience — Posted on 2025-03-02
5320 Functional Hierarchy of the Human Neocortex from Cradle to Grave
Taylor, H. P.; Huynh, K. M.; Thung, K.-H.; Lin, G.; Lyu, W.; Lin, W.; Ahmad, S.; Yap, P.-T.
10.1101/2024.06.14.599109 — neuroscience — Posted on 2025-03-02
5321 Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping
Kang, J. U.; Mattar, L.; Vergara, J.; Gobo, V.; Rey, H. G.; Heilbronner, S.; Watrous, A.; Hayden, B.; Sheth, S.; Bartoli, E.
10.1101/2025.02.28.640787 — neuroscience — Posted on 2025-03-02
5322 Cerebellar output shapes cortical preparatory activity during motor adaptation
Israely, S.; Ninou, H.; Rajchert, O.; Elmaleh, L.; Harel, R.; Mawase, F.; Kadmon, J.; Prut, Y.
10.1101/2024.07.12.603354 — neuroscience — Posted on 2025-03-02
5324 Broadband synergy versus oscillatory redundancy in the visual cortex
Roberts, L.; Aijala, J.; Burger, F.; Uran, C.; Jensen, M. A.; Miller, K. J.; Ince, R. A. A.; Vinck, M.; Hermes, D.; Canales-Johnson, A.
10.1101/2025.02.27.640666 — neuroscience — Posted on 2025-03-02
5325 MICROGLIAL EXTRACELLULAR VESICLES MEDIATE C1Q DEPOSITION AT THE PRE-SYNAPSE AND PROMOTE SYNAPTIC PRUNING
D'Arrigo, G.; Cutugno, G.; Golia, M. T.; Sironi, F.; Lombardi, M.; Colombo, S. F.; Frigerio, R.; Cretich, M.; Gagni, P.; Battocchio, E.; Barone, C.; Azzoni, E.; Bellini, S.; Saraceno, C.; Ghidoni, R.; Bendotti, C.; Paolicelli, R. C.; Gabrielli, M.; Verderio, C.
10.1101/2025.02.28.640756 — neuroscience — Posted on 2025-03-02
5326 EEG reveals online monitoring mechanisms of speech production
Mendonca Correia, J.; Kries, J.; Hausfeld, L.; Gracco, V.; Bonte, M.
10.1101/2025.03.01.640939 — neuroscience — Posted on 2025-03-02
5327 Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics
Torkenczy, K.; Reineke, L. C.; Dooling, S. W.; Henderson, B. W.; Itzhak, D.; Yang, B.; He, D.; Myers, R. M.; Walter, P.; Tyanova, S.; Costa-Mattioli, M.
10.1101/2025.02.28.640905 — neuroscience — Posted on 2025-03-02
5329 The astrocyte Fabp7 gene regulates diurnal seizure threshold and activity-dependent gene expression in mice
Lefton, M.; Flores, C. C.; Owada, Y.; Davis, C. J.; Ferraro, T. N.; Lee, Y.; Schroeder, W. L.; Gerstner, J. R.
10.1101/2025.03.01.640632 — neuroscience — Posted on 2025-03-02
5330 Spatial and molecular insights into microglial roles in cerebellar aging
Tsai, A. P.; Henze, D. E.; Ramirez Lopez, E.; Haberberger, J.; Dong, C.; Lu, N.; Atkins, M.; Costa, E. K.; Farinas, A.; Oh, H.; Moran-Losada, P.; Le Guen, Y.; Isakova, A.; Quake, S. R.; Wyss-Coray, T.
10.1101/2025.03.01.640978 — neuroscience — Posted on 2025-03-02
5331 Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells
Houl, J. H.; Bagheri-Yarmand, R.; Kunnimalaiyaan, M.; Miranda Mendez, P.; Kidd, J. L.; Dadbin, A.; Jurado Ruiz, A.; Parekh, P. A.; Henderson, Y. C.; Chari, N. S.; Thennavan, A. T.; Powell, R. T.; Stephan, C. C.; Zhao, X.; Maniakas, A.; Nurieva, R.; Busaidy, N. L.; Cabanillas, M. E.; Dadu, R.; Zafereo, M.; Wang, J. R.; Lai, S. Y.; Hofmann, M.-C.
10.1101/2025.02.17.637322 — cancer biology — Posted on 2025-03-02
5332 KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma
Huisman, D. H.; Chatterjee, D.; Svoboda, R. A.; Vieira, H. M.; Ireland, A. S.; Skupa, S.; Askew, J. W.; Frodyma, D. E.; Girard, L.; Fisher, K. W.; Kareta, M.; Minna, J.; Oliver, T. G.; Lewis, R. E.
10.1101/2022.02.11.480157 — cancer biology — Posted on 2025-03-02
5333 Differential effects of chronic restraint stress on two active avoidance tasks in rats
Lopez-Moraga, A.; De Ceuninck, M.; Van der Heyden, Y.; Vercammen, L.; Palme, R.; Vervliet, B.; Beckers, T.; Luyten, L.
10.1101/2025.02.28.640742 — animal behavior and cognition — Posted on 2025-03-02
5334 Enhancing plant broad-spectrum resistance through engineered pattern recognition receptors
Yang, Y.; Steidele, C. E.; Loeffelhardt, B.; Huang, L.; Jones, J. D.; Nuernberger, T.; Ding, P.; Gust, A. A.
10.1101/2025.02.26.640353 — plant biology — Posted on 2025-03-01
5337 Prospective evaluation of structure-based simulations reveal their ability to predict the impact of kinase mutations on inhibitor binding
Singh, S.; Gapsys, V.; Aldeghi, M.; Schaller, D.; Rangwala, A. M.; White, J. B.; Bluck, J. P.; Scheen, J.; Glass, W. G.; Guo, J.; Hayat, S.; de Groot, B. L.; Volkamer, A.; Christ, C. D.; Seeliger, M. A.; Chodera, J. D.
10.1101/2024.11.15.623861 — biophysics — Posted on 2025-03-02
5338 Redesigning the Eterna100 for the Vienna 2 folding engine
Koodli, R. V.; Rudolfs, B.; Romano, J.; Wayment-Steele, H. K.; Dunlap, W. A.; Eterna Structure Designers, ; Das, R.
10.1101/2021.08.26.457839 — bioinformatics — Posted on 2025-03-01
5339 Blood Vessels Bioengineered from Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells and Functional Scaffolds
Larrea Murillo, L.; Chen, Z.; Song, J.; Mitchel, A.; Woods, S.; Kimber, S. J.; Li, J.; Li, Y.; Wang, T.
10.1101/2025.02.03.636368 — bioengineering — Posted on 2025-03-01
5340 Temperature and Pressure Shaped the Evolution of Antifreeze Proteins in Polar and Deep Sea Zoarcoid Fishes
Bogan, S. N.; Surendran, N.; Hotaling, S.; Desvignes, T.; Bista, I.; Lins, L. S. F.; Eilertsen, M. H.; Le Francois, N. R.; Algayer, T.; Hamilton, S. L.; Frandsen, P. B.; Hoffmann, F. G.; Kelley, J. L.
10.1101/2024.08.24.609455 — evolutionary biology — Posted on 2025-03-02
5342 HMG Box-Containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression.
lee, S.-W.; Ekstrom, T.; Manalo, E.; Ye, S.; Berry, M.; Grygoryev, D.; Szczepaniak, M.; Lee, J.; Marmolejo, C. O.; Haverlack, S.; Lee, J.; Shah, V. M.; Keith, D.; Muschler, J. L.; Chin, K.; Sears, R. C.; Weisberg, S. P.; Morgan, T. K.; kim, j.
10.1101/2025.01.24.634817 — cell biology — Posted on 2025-03-01
5343 Tmbim5 loss causes muscle atrophy without exacerbating mcu or slc8b1 knockout phenotypes
Wasilewska, I.; Adamek-Urbanska, D.; Baranykova, S.; Majewski, L.; Macias, M.; Szybinska, A.; Methner, A.
10.1101/2024.12.03.626543 — cell biology — Posted on 2025-03-01
5344 Glucagon dysfunction in the liver induces hyperplasia of PP cells and the production of glucagon and pancreatic polypeptide double-positive cells
Nakagawa, Y.; Horii, T.; Fukunaka, A.; Sato, T.; Kobayashi, M.; Kitamura, T.; Hayashi, Y.; Nishimura, T.; Hatada, I.; Fujitani, Y.
10.1101/2025.02.27.640454 — cell biology — Posted on 2025-03-02
5345 Dysregulated intestinal nutrient absorption in obesity is associated with epigenomic alterations in epithelia
Badurdeen, D. S.; Li, Z.; Lee, J.-H.; Ma, T.; Bhagwate, A. V.; Latanich, R.; Dogiparthi, A.; Ordog, T.; Kovbasnjuk, O.; Kumbhari, V.; Foulke-Abel, J.
10.1101/2024.05.06.591758 — cell biology — Posted on 2025-03-02
5346 Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics
Helekal, D.; Mortimer, T. D.; Mukherjee, A.; Gentile, G.; Le Van, A.; Nicholas, R. A.; Jerse, A. E.; Palace, S. G.; Grad, Y. H.
10.1101/2025.02.03.636319 — microbiology — Posted on 2025-03-01
5347 Targeted Bacteriophage T4 Nanoparticles Reverse HIV-1 Latency in CD4+ Human T Cells
Batra, H.; Zhu, J.; Jain, S.; Ananthaswamy, N.; Mahalingam, M.; Tao, P.; Lange, C.; Hill, S.; Zhong, C.; Kearney, M. F.; Hu, H.; Maldarelli, F.; Rao, V. B.
10.1101/2021.07.20.453091 — immunology — Posted on 2025-03-02
5349 Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Castranio, E. L.; Varghese, M.; Argyrousi, E. K.; Tripathi, K.; Soderberg, L.; Bresnahan, E.; Lerner, D.; Garretti, F.; Zhang, H.; van de Loo, J.; Stimpson, C.; Talty, R.; Glabe, C.; Levy, E.; Wang, M.; Ilkov, M.; Zhang, B.; Lannfelt, L.; Guerin, B.; Lubell, W. D.; Rahimipour, S.; Dickstein, D. L.; Gandy, S. E.; Arancio, O.; Ehrlich, M. E.
10.1101/2025.02.25.639746 — neuroscience — Posted on 2025-03-01
5350 Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with alpha-Synucleinopathy
Zhylkibayev, A.; Starr, C. R.; Hossain, M. I.; Barodia, S. K.; Andrabi, S. A.; Grant, M. B.; Atigadda, V.; Gorbatyuk, M. S.; Gorbatyuk, O. S.
10.1101/2024.06.10.598149 — neuroscience — Posted on 2025-03-02
5351 Hydrodynamic Radius Determination of Tau and AT8 Phosphorylated Tau Mutants: A Combined Simulation and Experimental Study
Lohberger, C.; Marien, J.; Bridot, C.; Prevost, C.; Allegro, D.; Tatoni, M.; Landrieu, I.; Smet-Nocca, C.; Sacquin-Mora, S.; Barbier, P.
10.1101/2025.02.22.639620 — biophysics — Posted on 2025-03-01
5353 Multi-sample, multi-platform isoform quantification using empirical Bayes
Talukder, A.; Thavarekere, S.; Mehlferber, M.; Sheynkman, G. M.; Knowles, D. A.
10.1101/2025.02.08.637184 — bioinformatics — Posted on 2025-03-01
5354 Cheese3D: Sensitive Detection and Analysis of Whole-Face Movement in Mice
Daruwalla, K.; Martin, I. N.; Zhang, L.; Naglic, D.; Frankel, A.; Rasgaitis, C.; Zhang, X.; Ahmad, Z.; Borniger, J. C.; Hou, X. H.
10.1101/2024.05.07.593051 — animal behavior and cognition — Posted on 2025-03-01
5357 Disrupted Calcium Dynamics in Reactive Astrocytes Occur with Endfeet-Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer's Disease
Weiss, B. E.; Gant, J. C.; Lin, R.-L.; Gollihue, J. L.; Kraner, S. D.; Rucker, E. B.; Katsumata, Y.; Jiang, Y.; Nelson, P. T.; Wilcock, D. M.; Sompol, P.; Thibault, O.; norris, c. M.
10.1101/2025.01.24.634584 — neuroscience — Posted on 2025-03-01
5358 Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus
Traunmüller, L.; Duffy, E. E.; Liu, H.; Sanalidou, S.; Assad, E. G.; Sun, S.; Pajarillo, N. S.; Niu, N.; Griffith, E. C.; Greenberg, M. E.
10.1101/2024.10.31.621351 — neuroscience — Posted on 2025-03-01
5359 geneRNIB: a living benchmark for gene regulatory network inference
Nourisa, J.; Passemiers, A.; Stock, M.; Zeller-Plumhoff, B.; Cannoodt, R.; Arnold, C.; Tong, A.; Hartford, J.; Scialdone, A.; Moreau, Y.; Li, Y.; Luecken, M.
10.1101/2025.02.25.640181 — bioinformatics — Posted on 2025-03-01
5360 Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders
Espinoza, D. A.; Zrzavy, T.; Breville, G.; Thebault, S.; Marefi, A.; Mexhitaj, I.; Kan, M.; Bacchus, M.; Legaspi, J.; Fernandez, S.; Melamed, A.; Stubblebine, M.; Kim, Y.; Martinez, Z.; Diorio, C.; Schulte-Mecklenbeck, A.; Wiendl, H.; Rezk, A.; Li, R.; Narula, S.; Waldman, A.; Hopkins, S. E.; Banwell, B.; Bar-Or, A.
10.1101/2025.02.27.637541 — immunology — Posted on 2025-03-01
5361 Reading fluency development is predicted by cortical latency
Wang, F.; Nguyen, Q. T. H.; Kaneshiro, B.; Norcia, A. M.; McCandliss, B.
10.1101/2025.02.27.640126 — neuroscience — Posted on 2025-03-01
5362 Dissecting the sublexical route for reading: Frontal and parietal networks support learned orthography-to-phonology mappings
Dyslin, S. M.; DeMarco, A. T.; Staples, R.; Dickens, J. V.; Snider, S. F.; Friedman, R. B.; Turkeltaub, P. E.
10.1101/2025.02.27.640623 — neuroscience — Posted on 2025-03-01
5363 Tumor B cell infiltration in platinum-treated advanced urothelial carcinoma
Stawiski, K.; Perera-Bel, J.; Rodriguez-Vida, A.; Juanpere Rodero, N.; Lee, J.; Michaud, D. E.; Guerriero, J. L.; Mouw, K. W.; Bamias, A.; De Carvalho, F.; Bellmunt, J. L.
10.1101/2025.02.27.640395 — cancer biology — Posted on 2025-03-01
5364 Quantitative and large-scale investigation of human TCR-HLA Cross-Reactivity
Pan, M.; Tan, Y.; Tracy, W. Y.; Hu, J.; Fleming, J.; Hu, H.; Yang, Z.; Zhan, X.; Li, B.
10.1101/2025.02.20.639349 — bioinformatics — Posted on 2025-03-01
5366 CasGen: A Regularized Generative Model for CRISPR Cas Protein Design with Classification and Margin-Based Optimization
Nammi, B.; Jayasinghe-Arachchige, V. M.; Madugula, S. S.; Artiles, M.; Radler, C. N.; Pham, T.; Liu, J.; Wang, S.
10.1101/2025.02.28.640911 — genomics — Posted on 2025-03-01
5367 President Roosevelt's lions reveal a century of population fragmentation in Africa's largest carnivore
Armstrong, E. E.; Curry, C.; Solari, K. A.; Morgan, S.; Patterson, B. D.; Agwanda, B.; Parker, L. D.; McInerney, N.; Helgen, L. E.; Helgen, K. M.; Packer, C.; Petrov, D.; Hadly, E. A.; Maldonado, J. E.; Fleischer, R. C.; Campana, M. G.
10.1101/2025.02.26.640359 — evolutionary biology — Posted on 2025-03-01
5371 Chemical inhibition of Exon Junction Complex assembly impairs mRNA localization and neural stem cells ciliogenesis
Villa, T.; POURCELOT, O.; DIERKS, D.; FAUCOURT, M.; BUREL, C.; SLIMANI, F.; GUYONNET, L.; Spassky, N.; SCHWARTZ, S.; BERTRAND, E.; BENSAUDE, O.; LE HIR, H.
10.1101/2025.02.25.640098 — molecular biology — Posted on 2025-03-01
5372 The circular RNA landscape of human dorsal root ganglia and its association with opioid exposure
Koch, M. R.; Demeter, J. B.; Shilling, M. W.; Alles, S. R.; Westlund, K. N.; Ehsanian, R.; de la Pena, J. B.
10.1101/2025.02.26.640459 — molecular biology — Posted on 2025-03-01
5374 Mechanisms of maternal antibody interference to rotavirus vaccination
Chandler, T. L.; Woodyear, S.; Chen, V.; Lonergan, T.; Baker, N.; Harcourt, K.; Clare, S.; Ahmed, F.; Caddy, S. L.
10.1101/2025.02.26.640336 — immunology — Posted on 2025-03-01
5375 Programing Immunogenicity of Dengue EDIII Vaccine Antigens Using Engineered Outer Membrane Vesicles (OMVs)
DUVVADA, S.; Ahmed, F.; Khan, R. A.; Rahim, M. S.; Naaz, S.; Philips, A. M.; Putnam, D.; August, A.; Khan, N.
10.1101/2025.02.25.640071 — immunology — Posted on 2025-03-01
5376 Hyperglycemia-Driven Hepatic Immune Dysfunction Facilitates Microbial Dissemination Post-Myocardial Infarction
Tang, T. W. H.; Pasaribu, S. N. N.; Chen, H.-C.; Lin, P.-J.; Ruan, S.-C.; Wissel, E.; Kuo, C.-W.; Chen, P.; Ho, Y.-C.; Chang, Y.-C.; Hsieh, P. C. H.
10.1101/2025.02.26.640249 — immunology — Posted on 2025-03-01
5377 The metabolic program of inflammatory eosinophils accounts for chronic parasite-induced skin-disease
Barinberg, D.; Sebald, H.; Gold, T.; Rai, B.; Radtke, D.; Lerm, D.; Voehringer, D.; Jantsch, J.; Wirtz, S.; Antonova, A. U.; Colonna, M.; Bogdan, C.; Schleicher, U.
10.1101/2025.02.28.640104 — immunology — Posted on 2025-03-01
5382 Single cell-derived spheroids for real-time growth and metabolomic studies in breast cancer
Esteves, M.; Oliveira, F.; Teixeira, A.; Ibanez, A.; Garcia-Lizarribar, A.; Madarieta, I.; Fernandes, J. M.; Rodrigues, C.; Ainla, A.; Dieguez, L.; Olalde, B.; Xavier, M.; Abalde-Cela, S.
10.1101/2025.02.28.638104 — cancer biology — Posted on 2025-03-01
5383 Active learning for improving out-of-distribution lab-in-the-loop experimental design
Balashova, D.; Frank, R.; Kuzyakina, S.; Weltevreden, D.; Robert, P. A.; Sandve, G. K.; Greiff, V.
10.1101/2025.02.26.640110 — bioinformatics — Posted on 2025-03-01
5384 Open-Source DNA-Encoded Library Package for Design, Decoding, and Analysis: DELi
Wellnitz, J.; Novy, B. C.; Maxfield, T.; Zhilinskaya, I.; Lin, J.; Axtman, M.; Leisner, T.; Norris-Drouin, J. L.; Hardy, B. P.; Pearce, K. H.; Popov, K. I.
10.1101/2025.02.25.640184 — bioinformatics — Posted on 2025-03-01
5385 Accurate plasmid reconstruction from metagenomics data using assembly-alignment graphs and contrastive learning
Piera Lindez, P.; Danielsen, L. S.; Kovacic, I.; Pielies Avelli, M.; Nesme, J.; Jensen, L. J.; Nissen, J. N.; Sorensen, S. J.; Rasmussen, S.
10.1101/2025.02.26.640269 — bioinformatics — Posted on 2025-03-01
5387 Parallel multiOMIC analysis reveals glutamine deprivation enhances directed differentiation of renal organoids
Sarami, I.; Hekman, K. E.; Gupta, A. K.; Snider, J. M.; Ivancic, D.; Zec, M.; Kandpal, M.; Ben-Sahra, I.; Menon, R.; Otto, E. A.; Chilton, F. H.; Wertheim, J. A.
10.1101/2025.02.27.640060 — bioengineering — Posted on 2025-03-01
5390 Structure and Activity of the Essential UCH Family Deubiquitinase DUB16 from Leishmania donovani
Brannigan, J. A.; Kamran, M.; Jones, N. G.; Nightingale, E. M.; Dodson, E. J.; Ejazi, S. A.; Mottram, J. C.; Ali, N.; Wilkinson, A. J.
10.1101/2025.02.28.640783 — biochemistry — Posted on 2025-03-01
5391 Succinate dehydrogenase activity supports de novo purine synthesis
Nengroo, M. A.; Klein, A. T.; Carr, H. S.; Vidal-Cruchez, O.; Sahu, U.; McGrail, D. J.; Sahni, N.; Gao, P.; Asara, J. M.; Shah, H.; Mendillo, M. L.; Ben-Sahra, I.
10.1101/2025.02.26.640389 — biochemistry — Posted on 2025-03-01
5393 MyoRep: a novel reporter system to detect early muscle atrophy in vitro and in vivo
Re Cecconi, A. D.; Rizzi, N.; Barone, M.; Palo, F.; Lunardi, M.; Forti, M.; Maggi, A.; Ciana, P.; Terribile, G.; Chiappa, M.; Zentilin, L.; Piccirillo, R.
10.1101/2025.02.27.640021 — genetics — Posted on 2025-03-01
5396 A novel integrated framework to identify and characterize regional-scale pest insect dispersal
Dargent, F.; Reich, M. S.; Miller, M.; Studens, K.; Benvidi, N.; Perrault, K.; Aibueku, J.; Holmes, B.; Bataille, C.; Candau, J.-N.
10.1101/2025.02.26.640127 — ecology — Posted on 2025-03-01
5401 High-Resolution Proteomics Unveils Salivary Gland Disruption and Saliva-Hemolymph Protein Exchange in Plasmodium-Infected Mosquitoes
Alves e Silva, T. L.; Kanatani, S.; Barletta Ferreira, A. B.; Schwartz, C.; Talyuli, O. A. C.; Olivas, J.; Nagata, B. M.; Pala, Z. R.; Pascini, T.; Alves, D. A.; Zhao, M.; Suzuki, M.; Dorner, L. P.; Frischknecht, F.; Coppens, I.; Barillas-Mury, C.; Ribeiro, J. M. C.; Sinnis, P.; Vega-Rodriguez, J.
10.1101/2025.02.28.640873 — microbiology — Posted on 2025-03-01
5403 Metagenomic selections reveal diverse antiphage defenses in human and environmental microbiomes
Rodriguez-Rodriguez, L.; Pfister, J.; Schuck, L.; Martin, A. E.; Mercado-Santiago, L. M.; Tagliabracci, V. S.; Forsberg, K. J.
10.1101/2025.02.28.640651 — microbiology — Posted on 2025-03-01
5404 G-quadruplexes represent promising new targets to overcome multidrug-resistant fungal infections
Middleton, G.; Mahamud, F. O.; Storer, I.; Williams-Gunn, A.; Wostear, F.; Abdolrasouli, A.; Barclay, E.; Bradford, A.; Steward, O.; Schelenz, S.; McColl, J.; Leze, B.; van Rhijn, N.; Da Silva Dantas, A.; Furukawa, T.; Warren, D.; Waller, Z. A. E.; Bidula, S.
10.1101/2025.03.01.640902 — microbiology — Posted on 2025-03-01
5405 Single-cell multiomics reveals the distinct properties of neonatal and adult recent thymic emigrants
Tabilas, C.; Venturi, V.; Kean, C.; Minervina, A.; Thomas, P.; Grimson, A.; Grenier, J. K.; Davenport, M. P.; Smith, N. L.; Rudd, B. D.
10.1101/2025.02.26.640106 — immunology — Posted on 2025-03-01
5406 Dose-Response Immunomodulatory Effects of Mesenchymal Stem Cells-Derived Culture-Conditioned Media in Acute Graft-versus-Host-Disease
Mendiratta, M.; Mendiratta, M.; Mohanty, S.; Rai, S.; Gupta, R.; Dadhwal, V.; Bakhshi, S.; Pushpam, D.; Aggarwal, M.; Gupta, A. K.; Sahoo, R. K.
10.1101/2025.02.25.640019 — immunology — Posted on 2025-03-01
5411 Deep Learning-Enhanced Light Sheet Microscopy Unveils Semaglutide Impact on Cardiac Fibrosis
Barrado-Ballestero, S.; Yttergren, S. T.; Hahn, M.; Rosenkilde, M. B.; Jensen, D. M.; Christensen, M.; Thisted, L.; Holmberg, H. L.; Teixeira, G.; Biering-Soerensen, T.; Salinas, C. G.; Roostalu, U.
10.1101/2025.02.25.640039 — pathology — Posted on 2025-03-01
5412 Unraveling the YAP1-TGFβ1 axis: a key driver of androgen receptor loss in prostate cancer-associated fibroblasts
Brunner, E.; Damisch, E.; Groninger, M. E.; Nommensen, L.; Neumann, L.; Fotakis, G.; Trajanoski, Z.; Schäfer, G.; Ploner, C.; Karkampouna, S.; Bonollo, F.; Kruithof-de Julio, M.; Sampson, N.
10.1101/2025.02.25.640167 — cancer biology — Posted on 2025-03-01
5413 Structure of far-red allophycocyanin: stripped down and tuned up for low energy photosynthesis.
Consoli, G.; Leong, H. F.; Davis, G. A.; Richardson, T. F. A.; McInnes, A. M. C. C.; Murray, J. W.; Fantuzzi, A.; Rutherford, A. W.
10.1101/2025.02.25.640088 — biophysics — Posted on 2025-03-01
5416 Potency and selectivity of a novel pan-RAS inhibitor in 3D bioprinted organoid tumor models
De Nobrega, D. D.; Eiler, L. C.; Ahirwar, P.; Rawal, U. P.; Crawford, C. L.; Buchsbaum, D. J.; Keeton, A. B.; Maxuitenko, Y. Y.; Chen, X.; Piazza, G. A.; Tsung, A.; Budhwani, K. I.
10.1101/2025.02.25.640132 — bioengineering — Posted on 2025-03-01
5418 Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases.
Weinhaeupl, K.; Akopian, T.; Kandror, O.; Semchonok, D.; Arranz, R.; Teresa Bueno, M.; Gragera, M.; Chevreuil, M.; Raynal, B.; Liu, Y.; Lai, J.; Wuf, W.; W Bachovchin, W.; Goldberg, A.; J Rubin, E.; Fraga, H.
10.1101/2025.02.28.640722 — biochemistry — Posted on 2025-03-01
5419 TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability
Moffatt, C.; Arora, A.; Vaeth, K. F.; Guzman, B. B.; Bhardwaj, G.; Hoelscher, A.; Gifford, L. B.; Russ, H. A.; Dominguez, D.; Taliaferro, M.
10.1101/2025.02.25.640092 — molecular biology — Posted on 2025-03-01
5420 TXA11114: Discovery of an in vivo efficacious efflux pump inhibitor in Pseudomonas aeruginosa
Rosado-Lugo, J. D.; Datta, P.; Altiti, A.; Zhang, Y.; Lu, J.; Yuan, Y.; Parhi, A. K.
10.1101/2025.02.28.640909 — microbiology — Posted on 2025-03-01
5421 Consistency in floral volatiles impacts plant-pollinator interactions in the face of environmental change in the Eastern Himalayas
Gharpure, G.; Chanam, J.; Lamsal, D.; Ranganathan, Y.; Potdar, S.; Rai, S.; Saikia, A.; Rai, A.; Lepcha, D.; Subba, D.; Lepcha, D. T.; Talukdar, H.; Vedamurthy, J.; Rai, M.; Bhutia, O.; Rai, S.; Chettri, S.; Sankaran, M.; Olsson, S. B.
10.1101/2025.02.26.640254 — ecology — Posted on 2025-03-01
5422 New Insights into nuclear import and nucleolar localization of yeast RNA exosome subunits
Neto, V. G.; Cepeda, L. P. P.; Queiroz, B. R. S.; Cantaloube, S.; Leger-Silvestre, I.; Mangeat, T.; Albert, B.; Gadal, O.; Oliveira, C. C.
10.1101/2025.02.25.640171 — molecular biology — Posted on 2025-03-01
5423 Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis
Dsilva, A.; Wagner, A.; Itan, M.; Rhone, N.; Avlas, S.; Gordon, Y.; Davidian, N.; Sharma, S.; Razrvarina, E.; Zan-Bar, I.; Parnes, J. R.; Gorski, K. S.; Sherrill, J. D.; Varol, C.; Ziegler, S. F.; Rothenberg, M.; Munitz, A.
10.1101/2025.02.25.640192 — immunology — Posted on 2025-03-01
5424 APOE Genotype Influences on The Brain Metabolome of Aging Mice - Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 Genotype.
Borkowski, K.; Liang, N.; Zhao, N.; Arnold, M.; Huynh, K.; Karu, N.; Mahmoudiandehkordi, S.; Kueider-Paisley, A.; Kanekiyo, T.; Bu, G.; Kaddurah-Daouk, R.; Alzheimer's Disease Metabolomics Consortium,
10.1101/2025.02.25.640178 — systems biology — Posted on 2025-03-01
5425 Highly accurate prophage island detection with PIDE
Gao, H.; Li, B.; Guo, Z.; Zheng, L.; Junnan, C.; Liang, G.
10.1101/2025.02.26.640259 — bioinformatics — Posted on 2025-03-01
5427 Protein Secretion From Liver Ex Vivo Reveals Regulation of Hepatokines by Sex and Circadian Rhythm
Litwin, C.; Zhang, Q.; Li, Z.; Hernandez, S.; Keating, M.; Sato, T.; Sassone-Corsi, P.; Bieniek, K. F.; Koronowski, K. B.
10.1101/2025.02.25.640202 — molecular biology — Posted on 2025-03-01
5428 Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability
Cheng, J.; Cheng, M.; Sinha, S.; Cely, I.; Charugundla, S.; Han, M. T.; Zhang, G.; Zhou, Z.; Gladkikh, S.; Ahn, I. S.; Diamante, G.; Wang, Y.; Wang, Z.; Bennett, B.; Cai, H.; Allayee, H.; Hazen, S.; Lusis, A. J.; Yang, X.; Shih, D. M.
10.1101/2025.02.25.640205 — physiology — Posted on 2025-03-01
5429 Deconvolution to restore cryo-EM maps with anisotropic resolution
Li, J.; chen, Y.; Zheng, S.; McDonald, A.; Sedat, J. W.; Agard, D. A.; Cheng, Y.
10.1101/2025.02.23.639707 — biophysics — Posted on 2025-03-01
5430 Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE
Schroeder, A.; Loth, M.; Yao, S.; Luo, C.; Yan, H.; Zhang, D.; Piya, S.; Plowey, E.; Hu, W.; Clemenceau, J. R.; Jang, I.; Kim, M.; Barnfather, I.; Chan, S. J.; Reynolds, T.; Carlile, T.; Cullen, P.; Sung, J.-Y.; Tsai, H.-H.; Park, J. H.; Hwang, T. H.; Zhang, B.; Li, M.
10.1101/2025.02.25.640190 — genomics — Posted on 2025-03-01
5431 Free-living food intake and repopulation of the gut microbiota after a health-screening colonoscopy
Ghouri, Y. A.; Ericsson, A. C.; Anderson, J. M.; George, J. G.; Parks, E. J.; Anguah, K. O.
10.1101/2025.02.26.640308 — microbiology — Posted on 2025-03-01
5432 Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia
Joudi, A. M.; Gurkan, J. K.; Liu, Q.; Acosta, M. A. T.; Helmin, K. A.; Morales-Nebreda, L.; Mambetsariev, N.; Flores, C. P. R.; Abdala-Valencia, H.; Steinert, E. M.; Weinberg, S. E.; Singer, B. D.
10.1101/2025.02.25.640199 — immunology — Posted on 2025-03-01
5433 Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis
Sakuma, I.; Gaspar, R.; Nasiri, A.; Dufour, S.; Kahn, M.; Zhang, J.; LaMoia, T. E.; Guerra, M. T.; Taki, Y.; Kawashima, Y.; Yimlamai, D.; Perelis, M.; Vatner, D. F.; Petersen, K. F.; Huttasch, M.; Knebel, B.; Kahl, S.; Roden, M.; Samuel, V. T.; Tanaka, T.; Shulman, G. I.
10.1101/2025.02.25.640203 — pathology — Posted on 2025-03-01
5434 Phosphoinositide Depletion and Compensatory β-adrenergic Signaling in Angiotensin II-Induced Heart Disease: Protection Through PTEN Inhibition
Voelker, T.; Westhoff, M.; del Villar, S. G.; Thai, P. N.; Chiamvimonvat, N.; Nieves-Cintron, M.; Dickson, E. J.; Dixon, R. E.
10.1101/2025.02.23.639781 — physiology — Posted on 2025-03-01
5435 Injury Induced Connexin 43 Expression Regulates Endothelial Wound Healing
Sedovy, M. W.; Renton, M. C.; Roberts, K.; Leng, X.; Dennison, C.; Leaf, M.; Lampe, P. D.; Best, A. K.; Isakson, B.; Johnstone, S. R.
10.1101/2025.02.24.639946 — physiology — Posted on 2025-03-01
5437 Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics
Govorunova, E. G.; Sineshchekov, O. A.; Li, H.; Gou, Y.; Chen, H.; Yang, S.; Wang, Y.; Mitchell, S.; Palmateer, A.; S. Brown, L. S.; St-Pierre, F.; Xue, M. G.; Spudich, J. L.
10.1101/2025.02.24.639930 — biochemistry — Posted on 2025-03-01
5439 Mapping giant-tree density in the Amazon
DE LIMA, R. B. d.; Silva da Silva, D. A.; Nunes, M. H.; de Lima Bittencourt, P. R.; Groenendijk, P.; de Oliveira, C. P.; de Souza, D. G.; Caraciolo Ferreira, R. L.; Aleixo da Silva, J. A.; Aguirre-Gutierrez, J.; Jackson, T. D.; de Matos Filho, J. R.; da Silva Aparicio, P.; Gomes da Silva, J. P.; de Toledo, J. J.; Guedes, M. C.; Alves de Almeida, D. R.; Higuchi, N.; Wagner, F. H.; Ometto, J. P.; Gorgens, E. B.
10.1101/2025.02.25.640223 — ecology — Posted on 2025-03-01
5441 Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a multi-target mechanism of competition
BESSE, A.; Menetrey, Q.; JEAN-PIERRE, V.; Huc-Brandt, S.; Aujoulat, F.; Dupont, C.; Chiron, R.; Armengaud, J.; Jumas-Bilak, E.; Molle, V.; Grenga, L.; MARCHANDIN, H.
10.1101/2025.02.26.640371 — microbiology — Posted on 2025-03-01
5443 PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation
Xu, Y.; Chi, C.; Xin, Q.; Yu, J.; Zhang, Y.; Zhang, P.; Zheng, W.; Jiang, S.; Zheng, W.; Chen, N.; Wu, J.; Zhu, J.
10.1101/2025.02.24.639812 — immunology — Posted on 2025-03-01
5444 HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline
van Paassen, P. M.; Pasternak, A. O.; van Dort, K. A.; van Nuenen, A. C.; Maurer, I.; Boeser-Nunnink, B.; Buchholtz, N. V. E. J.; Mahmoud, T.; Lungu, C.; van Crevel, R.; Rokx, C.; Symons, J.; Nijhuis, M.; van der Veen, A. L. I. P.; Vogt, L.; Klouwens, M. J.; Prins, J. M.; Kootstra, N. A.; de Bree, G. J.
10.1101/2025.02.24.639839 — immunology — Posted on 2025-03-01
5446 Targeted and random mutagenesis of cassava brown streak disease susceptibility factors reveal molecular determinants of disease severity
Lin, Z.-J. D.; Stanton, M. K.; Hernandez, G. L.; De Meyer, E. J.; von Behren, Z.; Benza, K.; Tiley, H.; Hood, E.; Jensen, G.; Gilbert, K. B.; Carrington, J.; Bart, R.
10.1101/2025.02.27.640518 — plant biology — Posted on 2025-03-01
5449 Development of an image-guided non-vitrectomy subretinal access approach for trans-scleral cell and gene therapy delivery
Singh, M. S.; Guo, S.; Toomey, C. B.; McNally, M. M.; Harris-Bookman, S.; Li, K. V.; Agakishiev, D.; Wei, S.; Lee, S.; Perrino, K.; Wolfe, K. C.; Kang, J.
10.1101/2025.02.25.640217 — bioengineering — Posted on 2025-03-01
5450 A skeletal muscle-sympathetic nerve-intestine network underlies muscle inflammation and atrophy induced by immobilization
Hirata, Y.; Nomura, K.; Hozumi, K.; Sugawara, K.; Hosokawa, Y.; Uchiyama, K.; Inoue, T.; Nishigaki, T.; Liyuan, A.; Niikura, T.; Fukui, T.; Oe, K.; Kuroda, R.; Hamakita, S.; Kumagai, S.; Hirata, J.; Karsenty, G.; Ohbayashi, K.; Yada, T.; Iwasaki, Y.; Ogawa, W.
10.1101/2025.02.25.640219 — molecular biology — Posted on 2025-03-01
5453 Pain-stimulated ultrasound vocalizations and their impact on pain response in mice
Kasai, S.; Ukai, S.; Kuroda, J.; Yamauchi, T.; Yamada, D.; Saitoh, A.; Iriyama, S.; Suzuki, M.; Arita, K.; Nakano, Y.; Miyazaki, S.; Yoshizawa, K.
10.1101/2025.02.25.640235 — pharmacology and toxicology — Posted on 2025-03-01
5455 A novel in vitro 3D cancer model based on modular tissue engineering approach
Daneshvar Baghbadorani, N.; Bosso, M.; Greene, R.; Dzikowski, T.; Johannson, M.; Gagnon, A.; Chamberlain, M. D.
10.1101/2025.02.25.640239 — cancer biology — Posted on 2025-03-01
5456 Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Cappello, G.; Wodrascka, F.; Marquez-Vivas, G.; Radwan, A. E.; Anoop, P.; Mascheroni, P.; Fouchard, J.; Fabry, B.; Ambrosi, D. C.; de Beco, S.; Balland, M.; Boudou, T.
10.1101/2025.02.25.640067 — biophysics — Posted on 2025-03-01
5458 Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo
Han, X.; Xu, Y.; Ricciardi, A.; Xu, J.; Palanki, R.; Chowdhary, V.; Xue, L.; Gong, N.; Alameh, M.-G.; Pereanteau, W.; Wilson, J. M.; Weissman, D.; MITCHELL, M.
10.1101/2025.02.25.640222 — bioengineering — Posted on 2025-03-01
5459 The Open Pediatric Cancer Project
Geng, Z.; Wafula, E.; Corbett, R. J.; Zhang, Y.; Jin, R.; Gaonkar, K. S.; Shukla, S.; Rathi, K. S.; Hill, D.; Lahiri, A.; Miller, D. P.; Sickler, A.; Keith, K.; Blackden, C.; Chroni, A.; Brown, M. A.; Kraya, A. A.; Rood, B. R.; Resnick, A. C.; Van Kuren, N.; Maris, J. M.; Farrel, A.; Koptyra, M. P.; Trooskin, G. R.; Coleman, N.; Zhu, Y.; Stefankiewicz, S.; Abdullaev, Z.; Chinwalla, A. T.; Santi, M.; Naqvi, A. S.; Mason, J. L.; Koschmann, C. J.; Huang, X.; Diskin, S. J.; Aldape, K.; Farrow, B. K.; Ma, W.; Zhang, B.; Ennis, B. M.; Tasian, S.; Phul, S.; Lueder, M. R.; Zhong, C.; Dybas, J. M.; Wan
10.1101/2024.07.09.599086 — genomics — Posted on 2025-03-01
5460 Blood-based Epigenetic Instability Linked to Human Aging and Disease
Basrai, S.; Nofech-Mozes, I.; Detroja, R.; Scolari, F. L.; Bakhtiari, M.; Arruda, A.; Murphy, T.; Bratman, S. V.; Chan, S. M.; Minden, M. D.; Ahn, J.-S.; Kim, D. D. H.; Kridel, R.; Billia, F.; Abelson, S.
10.1101/2025.02.25.640133 — genetics — Posted on 2025-03-01
5462 Internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells
Aguzzi, E. A.; Yazdi, B. B.; Vardanjani, M. M.; Kimball, E.; Mary, S.; Zhang, K. Y.; Du, J.; Nagalingam, A.; Quillen, S.; Hariharakumar, S.; Quigley, H.; Zack, D. J.; Handa, J. T.; Johnson, T. V.
10.1101/2022.12.13.519327 — neuroscience — Posted on 2025-03-01
5466 Tracing the Spread of Celtic Languages using Ancient Genomics
McColl, H.; Kroonen, G.; Pinotti, T.; Koch, J.; Ling, J.; Demoule, J.-P.; Kristiansen, K.; Sikora, M.; Willerslev, E.
10.1101/2025.02.28.640770 — evolutionary biology — Posted on 2025-03-01
5468 A proper Excitatory/Inhibitory ratio is required to develop synchronized network activity in mouse cortical cultures
Crocco, E.; Iannello, L.; Tonelli, F.; Lagani, G.; Pandolfini, L.; Amato, G.; Di Garbo, A.; Cremisi, F.
10.1101/2025.02.28.640720 — developmental biology — Posted on 2025-03-01
5469 Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants
van Vlimmeren, A. E.; Tang, L. C.; Jiang, Z.; Iyer, A.; Voleti, R.; Krismer, K.; Gaublomme, J. T.; Jovanovic, M.; Shah, N. H.
10.1101/2025.02.26.640373 — molecular biology — Posted on 2025-03-01
5470 Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Castranio, E. L.; Varghese, M.; Argyrousi, E. K.; Tripathi, K.; Soderberg, L.; Bresnahan, E.; Lerner, D.; Garretti, F.; Zhang, H.; van de Loo, J.; Stimpson, C.; Talty, R.; Glabe, C.; Levy, E.; Wang, M.; Ilkov, M.; Zhang, B.; Lannfelt, L.; Guerin, B.; Lubell, W.; Rahimipour, S.; Dickstein, D. L.; Gandy, S. E.; Arancio, O.; Ehrlich, M. E.
10.1101/2025.02.25.639746 — neuroscience — Posted on 2025-03-01
5471 Ketamine reverses chronic stress-induced behavioral changes via the expression of Ca2+-permeable AMPA receptors in mice
Flowers, J. C.; Vetter, P. E.; Wiles, M. J.; Roh, S. H.; Black, E. R.; Bouckova, E.; Wustrau, M. H.; Lee, R.; Lee, S.-H.; Kim, S.
10.1101/2024.10.07.616991 — neuroscience — Posted on 2025-03-01
5474 Broadband synergy versus oscillatory redundancy in the visual cortex
Canales-Johnson, A.; Roberts, L.; Aijala, J.; Burger, F.; Uran, C.; Jensen, M. A.; Miller, K. J.; Ince, R. A. A.; Vinck, M.; Hermes, D.
10.1101/2025.02.27.640666 — neuroscience — Posted on 2025-03-01
5477 Rapid and efficient generation of human oligodendrocytes myelinating adult human cortical neurons
Martinez Curiel, R.; Rincon Cerrada, P.; Al Khani, A.-M.; Tsupykov, O.; Martin Hernandez, D.; Monni, E.; Savchenko, E.; R Rodriguez, L.; Kidnapillai, S.; Bruzelius, A.; Hidalgo, I.; Canals, I.; Bengzon, J.; Skibo, G.; Rylander Ottosson, D.; Falk, A.; Ahlenius, H.; Lindvall, O.; Kokaia, Z.; Palma Tortosa, S.
10.1101/2025.02.28.640804 — neuroscience — Posted on 2025-03-01
5478 Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p
Majnik, J.; Mantez, M.; Zangila, S.; Bugeon, S.; Guignard, L.; Platel, J.-C.; Cossart, R.
10.1101/2025.02.26.640367 — neuroscience — Posted on 2025-03-01
5480 Predicting the Regenerative Potential of Retinal Ganglion Cells Based on Developmental Growth Trajectories
Santos, J. R.; Li, C.; Andries, L.; Masin, L.; Nuttin, B.; Reinhard, K.; Moons, L.; Cuntz, H.; Farrow, K.
10.1101/2025.02.28.640775 — neuroscience — Posted on 2025-03-01
5481 Multi-omic analysis of the ciliogenic transcription factor RFX3 reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons
Lai, J.; Demirbas, D.; Phillips, K.; Zhao, B.; Wallace, H.; Seferian, M.; Nakayama, T.; Harris, H.; Chatzipli, A.; Lee, E. A.; Yu, T. W.
10.1101/2025.02.27.640588 — neuroscience — Posted on 2025-03-01
5487 Arabidopsis thaliana Iron Superoxide Dismutase FeSOD1 Protects ARGONAUTE 1 in a Copper-Dependent Manner
Tomassi, A. H.; Perea-Garcia, A.; Rodrigo, G.; Sanchez-Vicente, J.; Cisneros, A. E.; Olmos, M.; Andres-Borderia, A.; Lopez-Dolz, L.; Daros, J.-A.; Penarrubia, L.; Carbonell, A.
10.1101/2025.02.26.640378 — plant biology — Posted on 2025-03-01
5488 An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics
Yu, S.; Michon, M.; Lingappa, A. F.; Paulvannan, K.; Solas, D.; Staats, K. A.; Ichida, J.; Dey, D.; Rosenfeld, J.; Lingappa, V. R.
10.1101/2024.03.28.587289 — physiology — Posted on 2025-03-01
5490 Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber, M. K.; Widener, A. E.; Cuaycal, A. E.; Smurlick, D.; Butterworth, E. A.; Lenchik, N. I.; Chen, J.; Beery, M.; Hiller, H.; Verney, E.; Kusmartseva, I.; Slak Rupnik, M.; Campbell-Thompson, M.; Gerling, I. C.; Atkinson, M. A.; Mathews, C. E.; Phelps, E. A.
10.1101/2024.12.29.630665 — physiology — Posted on 2025-03-01
5491 Blocking Interleukin-1β transiently limits left ventricular dilation and reduces cardiac lymphangiogenesis during pressure-overload in mice
Heron, C.; Lemarcis, T.; Laguerre, O.; Bundalo, M.; Valentin, C.; Valet, M.; Dumesnil, A.; Michel, J.-B.; Mulder, P.; Zernecke, A.; Tardif San Martin, V.; Brakenhielm, E.
10.1101/2023.04.01.535056 — physiology — Posted on 2025-03-01
5492 Detecting microbial engraftment after FMT: sorting signals from noise using placebo sequencing and culture-enriched metagenomics
Shekarriz, S.; Szamosi, J. C.; Whelan, F. J.; Lau, J. T.; Libertucci, J.; Rossi, L.; Shah, M.; Wolfe, M.; Lee, C. H.; Moayyedi, P.; Surette, M. G.
10.1101/2024.09.11.612315 — microbiology — Posted on 2025-03-01
5495 High-throughput synthesis and specificity characterization of natively paired antibodies using oPool+ display
Ouyang, W. O.; Lv, H.; Liu, W.; Mou, Z.; Lei, R.; Pholcharee, T.; Talmage, L.; Tong, M.; Wang, Y.; Dailey, K. E.; Gopal, A. B.; Choi, D.; Ardagh, M. R.; Rodriguez, L. A.; Dai, X.; Wu, N. C.
10.1101/2024.08.30.610421 — immunology — Posted on 2025-03-01
5496 DNA origami vaccines program antigen-focused germinal centers
Romanov, A.; Knappe, G. A.; Ronsard, L.; Suh, H.; Omer, M.; Chapman, A. P.; Lewis, V.; Spivakovsky, K.; Canales, J.; Reizis, B.; Tingle, R.; Cottrell, C.; Schiffner, T.; Lingwood, D.; Bathe, M.; Irvine, D. J.
10.1101/2025.02.21.639354 — immunology — Posted on 2025-03-01