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Archive, 2025-04

2 Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids
Boyd, A. I.; Kafer, L. A.; F. Escapa, I.; Kambal, A.; Tariq, H.; Hilsenbeck, S. G.; Nguyen-Phuc, H.; Rajan, A.; Lensmire, J. M.; Patras, K. A.; Piedra, P. A.; Blutt, S. E.; Lemon, K. P.
10.1101/2024.09.25.614934 — microbiology — Posted on 2025-04-30
5 How Bacterial Vesicles Trigger Hearing Loss: The Role of Pyroptosis in Cochlear Damage
Xu, T.; Zhang, J.; Zhao, H.; Nong, H.; Yang, Q.; Yuan, Y.; Zhao, J.; Zhang, X.; Li, Y.; Tun, Z. M. M.; Bekale, L.; Cao, Z.
10.1101/2025.04.28.650954 — immunology — Posted on 2025-04-30
7 Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA
Gamas, K. R.; Seamons, T.; Dysart, M.; Fang, L.; Chappell, J.; Stadler, L.; Silberg, J.
10.1101/2025.04.29.651329 — synthetic biology — Posted on 2025-04-30
8 Actin Depolymerization Factors (ADFs) Moonlighting: Nuclear Immune Regulation by Interacting with WRKY Transcription Factors and Shaping the Transcriptome
Li, P.; Kelley, B.; Li, Z.; Procter, B.; Corrion, A.; Xie, X.; Sheick, R.; Lu, Y.-j.; Nomoto, M.; Wei, C.-i.; Tada, Y.; He, S.-Y.; Xiao, S.; Day, B.
10.1101/2025.04.29.651294 — plant biology — Posted on 2025-04-30
10 IsoBayes: a Bayesian approach for single-isoform proteomics inference
BOLLON, J.; SHORTREED, M. R.; JORDAN, B. T.; MILLER, R.; JEFFERY, E.; CAVALLI, A.; SMITH, L. M.; DEWEY, C.; SHEYNKMAN, G. M.; Tiberi, S.
10.1101/2024.06.10.598223 — bioinformatics — Posted on 2025-04-30
11 F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery
Sinha, S.; McLaren, E. G.; Mullick, M.; Penrose, H. M.; Tindle, C.; Singh, S.; Boland, B. S.; Ghosh, P.
10.1101/2024.07.16.602603 — bioinformatics — Posted on 2025-04-30
14 Dynamic convergence of autism disorder risk genes across neurodevelopment
Fernandez Garcia, M.; Retallick-Townsley, K.; Balafkan, N.; Pruitt, A.; Davidson, E.; Dai, Y.; Fitzpatrick, S. E.; Huang, T.-C.; Kibowen, A.; Warrell, J.; Meng, R.; Chu, Z.; Sen, A.; Cohen, S.; Livoti, O.; Khan, S.; Becker, C.; Luiz Teles Silva, A.; Liu, J.; Dossou, G.; Cheung, J.; Ghorbani, S.; Deans, P. J. M.; DeCiucis, M.; Shen, H.; Gerstein, M.; Gao, H.; Wang, Z.; Huckins, L.; Hoffman, E.; Brennand, K.
10.1101/2024.08.23.609190 — genetics — Posted on 2025-04-30
15 Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations
Dickson, P. E.; Datta, U.; Wilcox, T. D.; Auth, A. A.; Ball, R. L.; Dunn, M.; Fisher, H. S.; Klein, A.; Leonardo, M. R.; Roy, T. A.; Saul, M. C.; Bubier, J. A.; Gagnon, L. H.; Philip, V. M.; Tarantino, L. M.; Jentsch, J. D.; Chesler, E. J.
10.1101/2025.04.23.650259 — genetics — Posted on 2025-04-30
23 Close-Up of vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM
Nair, A.; Nair, A.; Stock, P.; Jain, A.; Somerville, E.; Sanyal, A.; Kirchhausen, T.
10.1101/2025.04.23.650353 — cell biology — Posted on 2025-04-30
26 Exploring GPCR-mediated optogenetic modulation of seizure network in a pig model of Temporal Lobe Epilepsy
Chang, S.-y.; Bar-Or, K. L.; Mivalt, F.; Maltais, D.; Kfir, Y.; Kim, J.; Kim, I.; Hershko, M.; Daily, J.; Swissa, E.; Levi, O.; Yizhar, O.; Eldar, Y.; Worrell, G.
10.1101/2025.01.23.634545 — neuroscience — Posted on 2025-04-30
28 Large-scale infra-slow dynamics of extracellular potentials linked to synchronous states revealed by graphene neural probes
Garcia-Cortadella, R.; Cisneros-Fernandez, J.; Schwesig, G.; Shahidi, A.; Umurzakova, A.; Schaefer, N.; Aguilar, J.; Masvidal-Codina, E.; Del Corro, E.; Mohrlok, R.; Kurnoth, M.; Paetzold, J.; Jeschke, C.; Loeffler, H.; Meents, J.; Illa, X.; Serra-Graells, F.; Guimera-Brunet, A.; Garrido, J. A.; Sirota, A.
10.1101/2024.12.20.629545 — neuroscience — Posted on 2025-04-30
29 Partial Correlation as a Tool for Mapping Functional-Structural Correspondence in Human Brain Connectivity
Santucci, F.; Jimenez-Marin, A.; Gabrielli, A.; Bonifazi, P.; Ibanez-Berganza, M.; Gili, T.; Cortes, J. M.
10.1101/2024.10.16.618230 — neuroscience — Posted on 2025-04-30
30 Control of leaflet movement pattern by a novel PP2C phosphatase DLM1 in Medicago truncatula
Zhou, D.; Guo, S.; Yang, W.; Zhao, B.; Zhao, W.; Zhou, S.; Mao, Y.; Zhang, H.; Fang, Y.; He, L.; Yang, L.; Liu, C.; Chen, J.; Bai, Q.
10.1101/2025.04.28.650909 — plant biology — Posted on 2025-04-30
32 The Building Blocks of Early Land Plants: Glycosyltransferases and Cell Wall Architecture in the model liverwort Marchantia polymorpha
Kang, H. S. F.; Tong, X.; Mariette, A.; Leong, M.; Beahan, C.; Flores-Sandoval, E.; Pedersen, G.; Rautengarten, C.; Bowman, J. L.; Ebert, B.; Bacic, A.; Doblin, M.; Persson, S.; Lampugnani, E. R.
10.1101/2025.04.30.651426 — plant biology — Posted on 2025-04-30
33 Molecular dynamics analyses of CLDN15 pore size and charge selectivity
McGuinness, S.; Li, P.; Li, Y.; Fuladi, S.; Konar, S.; Bafghi, S. S.; Sidahmed, M.; Li, Y.; Shen, L.; Khalili-Araghi, F.; Weber, C. R.
10.1101/2023.08.16.553400 — physiology — Posted on 2025-04-30
34 PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
Wang, J.; Shi, Y.; Wang, Y.; Shen, Y.; Liu, H.; Sun, S.; Wang, Y.; Zhou, X.; Zhou, Y.; Zeng, X.; Li, J.; Chen, Q.
10.1101/2024.07.23.604769 — cancer biology — Posted on 2025-04-30
35 Prolonged Crowding Initiates Tumor Invasion with Mechanomemory by Pressure-Sensation of Membrane Domains
Zhao, X.; Tan, M.; Li, L.; Lin, X.; Li, Z.; Wang, X.; Song, B.; Guo, Z.; Chen, T.; Hou, S.; Fan, J.; Wang, S.; Zhang, Y.; Fan, Y.; Du, J.
10.1101/2024.07.28.605413 — cancer biology — Posted on 2025-04-30
36 Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids
Ennis, C. S.; Seen, M.; Chen, A.; Kang, H.; Ilinski, A.; Mahdaviani, K.; Ko, N. Y.; Monti, S.; Denis, G. V.
10.1101/2024.09.13.612950 — cancer biology — Posted on 2025-04-30
37 Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments
Flowers, J.; Echols, N.; Correy, G.; Jaishankar, P.; Togo, T.; Renslo, A. R.; van den Bedem, H.; Fraser, J. S.; Wankowicz, S. A.
10.1101/2024.09.20.613996 — biophysics — Posted on 2025-04-30
40 Tumor-targeted hydroxyapatite nanoparticles for dual-mode diagnostic imaging and near-infrared light-triggered photothermal cancer therapy
Palanikumar, L.; Yasin, F. M.; Munkhjargal, I.; Boitet, M.; Ali, L.; Ali, M. S.; Straubinger, R.; Barrera, F. N.; Magzoub, M.
10.1101/2025.02.20.639217 — bioengineering — Posted on 2025-04-30
41 Genome-wide association study in European beech (Fagus sylvatica L.) for drought stress traits
Tost, M.; Grigoriadou-Zormpa, O.; Wilhelmi, S.; Targem, M. B.; Mueller, M.; Wildhagen, H.; Curtu, A. L.; Beissinger, T.; Gailing, O.
10.1101/2025.04.08.647712 — genetics — Posted on 2025-04-30
42 Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon
Aykanat, T.; Debes, P. V.; Jansouz, S.; Gueguen, L.; House, A. H.; Ruokolainen, A.; Erkinaro, J.; Pritchard, V. L.; Primmer, C. R.; Bolstad, G. H.
10.1101/2024.12.05.627014 — ecology — Posted on 2025-04-30
43 Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS
Zacco, E.; Gilodi, M.; Armaos, A.; Waldron, F.; Rupert, J.; Schneider, N.; Gregory, J.; Tartaglia, G. G.
10.1101/2025.04.30.651570 — biochemistry — Posted on 2025-04-30
45 Piwi and piRNAs repress transcription of aberrant rRNA genes containing retrotransposon fragments
Fefelova, E. A.; Shatskikh, A. S.; Mikhaleva, E. A.; Abramov, Y. A.; Lavrov, S. A.; Pirogov, S. A.; Poltorachenko, V. A.; Ilin, A. A.; Zamore, P. D.; Klenov, M. S.
10.1101/2025.04.30.651568 — molecular biology — Posted on 2025-04-30
46 PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial Biology
Michel, H. A.; McCallum, P.; Wu, W.; Lee, J. L.; Luo, S.; Chan, C. N.; Schaffenrath, J.; Yeo, Y. Y.; Yiu, S. P. T.; Wang, Y.; Parmelee, L.; Wang, H.; Burgess, M.; El Ahmar, N.; Zhang, Z. X.; Keane, C.; Lim, T.; Signoretti, S.; Del Rincon, S. V.; Zhao, B.; McIlwain, D. R.; Bai, Y.; Chen, F.; Jiang, S.
10.1101/2025.04.30.651463 — molecular biology — Posted on 2025-04-30
48 High frequency body site translocation of nosocomial Pseudomonas aeruginosa
Fisher, L. W. S.; Thorpe, H. A.; Sassera, D.; Corander, J.; Bryant, J. M.
10.1101/2025.04.30.651244 — microbiology — Posted on 2025-04-30
49 Competition with Pseudomonas aeruginosa induces Staphylococcus aureus in an antibiotic-tolerant viable but non culturable state
Lapinska, U.; Chandran, G.; Tunstall, t.; Zborowsky, S.; Tolle, G.; Verderosa, A.; Garcia Castillo, M.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; Young, A. R.; Canton, R.; Caboni, P.; Blaskovich, M.; Warris, A.; Tsaneva-Atanasova, K.; Pagliara, S.
10.1101/2025.04.30.651255 — microbiology — Posted on 2025-04-30
50 Gut bacteria gatekeep host-specific colonization of a commensal fungus that boosts type 2 immunity
Han, G.; Yunker, R.; Hasan, M. H.; Bruce, A.; Baldaro, K.; Pacia, J.; Lockwood, O.; Miralles, D. M.; Jarjour, N. N.; Chellappa, K.; Vaishnava, S.; Beura, L. K.
10.1101/2025.04.30.651489 — microbiology — Posted on 2025-04-30
51 High-resolution phenotypic screen in zebrafish identifies novel regulators of CNS axon diameter growth
Eichel-Vogel, M. A.; Soong, D.; Sequeira, M. N.; Marshall-Phelps, K. L.; Bin, J. M.; Lyons, D. A.
10.1101/2025.04.29.651302 — neuroscience — Posted on 2025-04-30
53 Design of an orally bioavailable small molecule that modulates the microtubule-associated protein tau's pre-mRNA splicing
Zhang, P.; Taghavi, A.; Abe, M.; Aikawa, H.; Akahori, Y.; Chen, J. L.; Tong, Y.; Baisden, J. T.; Cameron, M. D.; childs-disney, J. L.; Disney, M. D.
10.1101/2025.04.30.651234 — biochemistry — Posted on 2025-04-30
54 Reduced heparan sulfate levels in cerebrospinal fluid reflect brain neuron correction in Sanfilippo B mice
Le, S. Q.; Sorensen, A.; Sukupolvi, S.; Jewhurst, G.; Austin, G.; Doray, B.; Cooper, J. D.; Dickson, P.
10.1101/2025.04.30.651515 — biochemistry — Posted on 2025-04-30
55 RNase H1 levels dramatically affect mitochondrial genome maintenance with little impact on nuclear R-loops in murine B cells
Sakhuja, K.; Hartono, S. R.; Sanz, L. A.; Ijiri, E.; Darling, C.; Dye, L.; Iben, J. R.; Chon, H.; Cerritelli, S.; Crouch, R.; Chedin, F.
10.1101/2025.04.30.651504 — genomics — Posted on 2025-04-30
56 Dissecting regulatory syntax in human development with scalable multiomics and deep learning
Liu, B. B.; Jessa, S.; Kim, S. H.; Ng, Y. T.; Higashino, S. i.; Marinov, G. K.; Chen, D. C.; Parks, B. E.; Li, L.; Nguyen, T. C.; Wang, S. K.; Wang, A. T.; Tan, S. Y.; Kosicki, M.; Pennacchio, L. A.; Ben-David, E.; Pasca, A. M.; Kundaje, A.; Farh, K. K. H.; Greenleaf, W. J.
10.1101/2025.04.30.651381 — genomics — Posted on 2025-04-30
58 Molecular surface mimicry enables CRBN to target G3BP2 for degradation
Annunziato, S.; Quan, C.; Donckele, E. J.; Lamberto, I.; Bunker, R. D.; Zlotosch, M.; Schwander, L.; Murthy, A.; Wiedmer, L.; Staehly, C.; Matysik, M.; Gilberto, S.; Kapsitidou, D.; Wible, D.; De Donatis, G. M.; Trenh, P.; SriRamaratnam, R.; Strande, V.; Almeida, R.; Dolgikh, L.; DeMarco, B.; Tsai, J.; Sadok, A.; Zarayskiy, V.; Walter, M.; Tiedt, R.; Lumb, K. J.; Bonenfant, D.; Fasching, B.; Castle, J. C.; Townson, S. A.; Gainza, P.; Petzold, G.
10.1101/2025.04.30.651496 — molecular biology — Posted on 2025-04-30
65 Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin
Guo, Z.; Banas, V. S.; He, Y.; Weiland, E.; Xu, J.; Tan, Y.; Xiao, Z.; Brody, S. L.; Boon, A. C. M.; Janetka, J. W.; Vahey, M. D.
10.1101/2025.04.30.651529 — microbiology — Posted on 2025-04-30
67 Imbalance in gut microbial interactions as a marker of health and disease
Lopez, R. C.; Bonachela, J.; Bello, M. G. D.; Manhart, M.; Levin, S.; Blaser, M.; Munoz, M. A.
10.1101/2025.04.30.651474 — microbiology — Posted on 2025-04-30
68 Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Burgener, S.; Milner, M. T.; Dey, S.; Morgan, P.; Blackmore, D. G.; Frampton, E.; Miller, G.; Durate de Oliveira, M.; Kenney, K. M.; Bajracharya, R.; Baumgartner, U.; Collins, T. T. J. C.; Xiong, Z.; Nguyen, Q.; Meikle, P.; Bodea, L.-G.; Clouston, A.; Boucher, D.; Goetz, J.; Murphy, A. J.; Kaye, P. J.; Schroder, K.
10.1101/2025.04.28.651119 — immunology — Posted on 2025-04-30
70 Passive muscle forces in Drosophila are large but insufficient to support a flys weight
Wang, N.; Babski, H.; Perdomo, J. E.; McMahan, S. B.; Ramakrishnan, A.; Biswas, T.; Bhandawat, V.
10.1101/2025.04.29.651225 — neuroscience — Posted on 2025-04-30
72 Kozak sequence libraries for characterizing transgenes across expression levels
Shukla, N.; Kamath, N. D.; Snell, J. C.; Bruchez, A. M.; Matreyek, K. A.
10.1101/2025.04.28.651141 — genetics — Posted on 2025-04-30
74 Anoxia activates CRISPR-Cas immunity in the intestine
Campbell, I. W.; Basta, D. W.; Zingl, F. G.; Sullivan, E. J.; Doranga, S.; Waldor, M. K.
10.1101/2025.04.30.651551 — microbiology — Posted on 2025-04-30
75 MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by Preserving Mitochondrial Integrity
Sah, V.; Potharaju, P. S.; Nair, K. S.; Sahoo, P. P.; Pooja, A. R.; Basu, D.; Tandel, D.; Varadarajan, K. S.; Chauhan, S.; Patel, A. B.; Harshan, K. H.
10.1101/2025.04.28.651145 — immunology — Posted on 2025-04-30
76 Genetic differentiation in Anopheles stephensi from India and Ethiopia: insights from mitochondrial genome analysis
Gupta, B.; Sumitha, M. K.; Kalimuthu, M.; Pandiyan, G. N.; Natarajan, R.; Gopalakrishnan, S.; Paramasivan, R.; Rahi, M.; Kumar, A.
10.1101/2025.04.28.650555 — zoology — Posted on 2025-04-30
77 Whole-genome sequencing reveals the molecular basis of sex determination in the dioecious wild yam Dioscorea tokoro
Kudoh, A.; Natsume, S.; Sugihara, Y.; Kato, H.; Abe, A.; Oikawa, K.; Shimizu, M.; Itoh, K.; Tsujimura, M.; Takano, Y.; Sakai, T.; Adachi, H.; Ohta, A.; Ohtsu, M.; Ishizaki, T.; Terachi, T.; Terauchi, R.
10.1101/2025.04.28.650915 — plant biology — Posted on 2025-04-30
78 SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters.
Nagraj, S. K.; Joy, C. M.; Narayan, R.; Shiraz, R.; Kaur, S.; Khatun, O.; Dubey, S.; Ng, J.; MISHRA, N.; Tripathi, S.
10.1101/2023.06.19.545534 — pathology — Posted on 2025-04-30
80 Small molecule bioactivity benchmarks are often well-predicted by counting cells
Seal, S.; Dee, W.; Shah, A.; Zhang, A.; Titterton, K.; Cabrera, A. A.; Boiko, D.; Beatson, A.; Puigvert, J. C.; Singh, S.; Spjuth, O.; Bender, A.; Carpenter, A. E.
10.1101/2025.04.27.650853 — bioinformatics — Posted on 2025-04-30
81 PepSeek: Universal Functional Peptide Discovery with Cooperation Between Specialized Deep Learning Models and Large Language Model
Gong, H.; Wang, Y.; Kong, Q.; Li, X.; Li, L.; Wan, B.; Zhao, Y.; Chen, G.; Chen, J.; Zhang, J.; Yu, Y.; Yang, X.; Zuo, X.; Li, Y.
10.1101/2025.04.29.641945 — bioinformatics — Posted on 2025-04-30
82 Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation
Miller, S. L.; Green, K. M.; Crone, B.; Switzenberg, J. A.; Tank, E. M.; Krans, A.; Jansen-West, K.; Wieland, C.; Ji, E.; Petrucelli, L.; Barmada, S.; Boyle, A. P.; Todd, P.
10.1101/2025.04.27.650888 — neuroscience — Posted on 2025-04-30
83 Whey Protein Phospholipid Concentrate Supplementation Prevents High-Fat Diet Induced Cognitive Impairment in Wistar Rats by Promoting Brain Neuronal Connectivity and Sphingolipid Clearance
Sylvestre, D. A.; Liang, N.; Galan, J. G.; Safar, A. M.; Souza, F. D.; Bancks, M. C.; Sundaram, V. S.; Scott, B. W.; Schalich, K.; Goodson, M. L.; Rutkowsky, J. M.; Galang, K. G.; Ozturk, G.; Mills, D. A.; Barile, D.; Taha, A. Y.
10.1101/2025.04.29.647813 — neuroscience — Posted on 2025-04-30
84 Normal breast tissue classifiers assess large-scale tissue compartments with high accuracy
Chen, S.; Parreno-Centeno, M.; Booker, G.; Verghese, G.; Mohamed, F. S.; Arslan, S.; Pandya, P.; Oozeer, A.; D'Angelo, M.; Barrow, R.; Nelan, R.; Sobral-Leite, M.; Martino, F. d.; Brisken, C.; Smalley, M. J.; Lips, E.; Gillett, C.; Jones, L. J.; Banerji, C. R. S.; Pinder, S. E.; Grigoriadis, A.
10.1101/2025.04.27.649481 — pathology — Posted on 2025-04-30
85 Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade
Honigsberg, R.; Cruz, T. D.; Yoffe, L.; Tang, M. S.; Ozgenel, D. O.; Markowitz, G.; Micheal, M.; Singh, A.; Altorki, N. K.; Elemento, O.; Villena-Vargas, J.
10.1101/2025.04.27.650862 — cancer biology — Posted on 2025-04-30
86 Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
Liu, X.; Cortes, E.; Ji, Y.; Zhao, K.; Ho, J.; Liu, Y. S.; Davicioni, E.; Feng, F. Y.; Alumkal, J. J.; Spratt, D. E.; Sweeney, C. J.; Yu, H.; Hu, Q.; Cheng, Z.; Zhang, D.; Chatta, G.; Nastiuk, K. L.; Goodrich, D. W.; Rycaj, K.; Jamroze, A.; Kirk, J. S.; Puzanov, I.; Liu, S.; Wang, J.; Tang, D. G.
10.1101/2025.04.27.650697 — cancer biology — Posted on 2025-04-30
87 Surface-immobilized fibronectin conformation drives synovial fluid adsorption and film formation
Ahmed, S. T.; Honey, U.; Vitkova, L.; Pinto, D. R. J.; Flores, W.; Cutter, K. A.; Lunny, K. L.; Wen, Y.; De France, K.; Eguiluz, R. C. A.
10.1101/2025.04.27.650860 — biophysics — Posted on 2025-04-30
94 Early-life Helicobacter pylori infection worsens metabolic state in mice receiving a high-fat diet
Klove, S.; Graversen, K. B.; Agerbo Rasmussen, J.; Assis, J.; Schluter, J.; Blaser, M. J.; Andersen, S. B.
10.1101/2025.04.27.650497 — evolutionary biology — Posted on 2025-04-30
95 Beneficial fungi are major drivers of root fungal microbiome assembly and network robustness
Mosca, S.; Francomano, E.; Aci, M. M.; Mohamed, N. Z.; Schena, L.; Malacrino, A.
10.1101/2025.04.27.650865 — ecology — Posted on 2025-04-30
97 Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway
Jiang, H.; Liu, L.; He, S.; Qu, S.; Yang, Y.; Kang, G.; Wu, M.; Liu, H.; Zhang, Y.; Chen, Y.; Wang, Z.; Wang, L.; Wang, Q.; Tian, W.; Ye, T.; Han, J.; Wang, H.; Huang, Y.
10.1101/2025.04.27.650830 — immunology — Posted on 2025-04-30
98 Sleep patterns predicting stress resilience are dependent on sex
Bush, B. J.; Mohamed, A.; Andrews, E.-J.; Cain, G.; Fawole, A.; Johnson, H.; Arocho, A.; Qiao, Z.; Paul, K. N.; Ehlen, J. C.
10.1101/2024.12.30.630808 — neuroscience — Posted on 2025-04-30
100 Dexamethasone-Induced p57-Mediated Quiescence Drives Chemotherapy Resistance in Sonic Hedgehog Medulloblastoma
Sharma, A.; Ellis, L.; Andrews, K.; Brown, A. S.; Fuller, M. T.; Scott, M. P.; Purzner, T.; Purzner, J.
10.1101/2025.04.27.650711 — cancer biology — Posted on 2025-04-30
103 SCRIPT: predicting single-cell long-range cis-regulation based on pretrained graph attention networks
Zhang, Y.; Jiao, Y.; Liu, Y.; Guo, X.; Wu, Y.; Li, J.; Han, L.; Xu, Y.; Gao, X.; Qi, Y.; Cheng, Y.; He, Y.
10.1101/2025.04.27.650894 — bioinformatics — Posted on 2025-04-30
104 MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers
Ghamei, B.; Rosu, A.; Kuddannaya, S.; Laurent, G.; Bazzi, R.; Roux, S.; Sakeri-Zadeh, A.; Bulte, J.
10.1101/2025.04.27.650870 — bioengineering — Posted on 2025-04-30
107 CISH, a novel intracellular immune checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints
Cano, F.; Bravo Blas, A.; Colombe, M.; Cerrato, C.; Venegalla, R.; Preham, O.; Burns, E.; Mortimer, P.; Slipek, N.; Johnson, M. J.; Webber, B. R.; Moriarity, B. S.; Lou, E.; Choudhry, M.; Klebanoff, C. A.; Henley, T.
10.1101/2025.04.26.650767 — cancer biology — Posted on 2025-04-30
109 Sludge liquefaction and stratification enable ultra-high digestion rate and resource recovery for waste activated sludge treatment
Wang, S.; Lu, Q.; Liang, Z.; Wang, C.; Shi, J.; Jia, B.; Liang, Y.; Jiang, D.; Liang, D.; Zhang, Y.; Dolfing, J.; Wang, P.; Wang, L.; Qiu, R.
10.1101/2025.04.27.650825 — bioengineering — Posted on 2025-04-30
110 A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity
Hennig, S.; Gennermann, K.; Elezkurtaj, S.; Seitz, V.; Hirsch, B.; Droege, A.; Schaper, S.; Bents, D.; Eggeling, S.; Beushausen, C.; Herbst, H.; Genzel, N.; Gloekler, J.; Lennerz, V.; Woelfel, C.; Doppler, C.; Hammer, R.
10.1101/2025.04.26.650660 — immunology — Posted on 2025-04-30
111 Environmental enrichment selectively restores brain metabolic activity during cocaine abstinence
Belujon, P.; Lardeux, V.; Dugast, E.; Serriere, S.; Busson, J.; Bodard, S.; Tauber, C.; Galineau, L.; Solinas, M.
10.1101/2025.04.26.650753 — neuroscience — Posted on 2025-04-30
114 Reducing the CAV1-dependent trafficking of G6PC1 in the liver protects against the development of type 2 diabetes
Da Costa, L.; Saint-Beat, C.; Bron, C.; Lang, A.; Duchampt, A.; Micoud, M.; Evrard, F.; Mithieux, G.; Stein, A. G.
10.1101/2025.04.26.650768 — physiology — Posted on 2025-04-30
115 Immunotherapy for ovarian cancer is improved by tumor targeted delivery of a neoantigen surrogate
Scanlon, L. R.; Gabor, L.; Khouri, O. R.; Ahmad, S.; Levy, E.; Buckley, E.; Ouedraogo, A.; Kuo, D. Y.-S.; Lin, K.; Nevadunsky, N.; Isani, S.; Sun, S.; Gravekamp, C.
10.1101/2023.10.11.561944 — cancer biology — Posted on 2025-04-30
118 Neural dynamics encoding risky choices during deliberation reveal separate choice subspaces
Peters, L.; Roadarmel, A.; Overton, J. A.; Stickle, M.; Lin, J.; Kong, Z.; Saez, I.; Moxon, K. A.
10.1101/2025.04.29.651314 — neuroscience — Posted on 2025-04-30
119 The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis
Durumutla, H. B.; Haller, A.; Noble, G.; Prabakaran, A. D.; McFarland, K.; Latimer, H.; Rajput, A.; Akinborewa, O.; Khales, B. N.; Hui, D. Y.; Quattrocelli, M.
10.1101/2024.11.27.625727 — physiology — Posted on 2025-04-30
120 SNX-2112 inhibits the ERBB3high tumor population in Plexiform Neurofibromas
Khan, S.; Aina, O.; Veneklasen, X.; Bruckert, B.; Njoya, K.; Alson, D.; Sun, L.; Zyaed, H.; Sun, D.
10.1101/2025.04.26.650740 — cancer biology — Posted on 2025-04-30
121 Plasma protein biomarkers for the early detection of gastric preneoplasia and cancer: a prospective study
Gianetto, Q. G.; Michel, V.; Douche, T.; Nozeret, K.; Zaanan, A.; Colussi, O.; Trouilloud, I.; Pernot, S.; Ungeheuer, M.-N.; Julie, C.; Jolly, N.; Taieb, J.; Lamarque, D.; Matondo, M.; Touati, E.
10.1101/2025.04.29.651246 — cancer biology — Posted on 2025-04-30
128 Chromosome-level genome assembly of the lemon sole Microstomus kitt (Pleuronectiformes: Pleuronectidae)
Nebenfuehr, M.; Prochotta, D.; Nilsson, M. A.; de Jong, M. J.; Yasici, T. D.; Langefeld, F.; Wokoeck, H.; Jilg, J.; Bender, S. C.; Zangl, M. M.; Williams, K.; Janke, A.; Sonnewald, M.; Muloongo, M.; Ortega Guatame, J. M.
10.1101/2025.04.29.651060 — evolutionary biology — Posted on 2025-04-30
134 Optimizing canine T cell activation, expansion, and transduction
Davis, T. W.; Holmes, J. C.; He, A.; Hess, P. R.; Mariani, C. L.; Brudno, Y.
10.1101/2025.04.26.650803 — immunology — Posted on 2025-04-30
135 Upper Airway Gene Expression in Hospitalized Children with Rhinovirus-induced Respiratory Illnesses
Kreger, J. E.; Sliwicki, A. L.; Essoh, S. N.; Li, Y.; Jayachandran, C.; Czapla, J. A.; Lewis, T. C.; Kirkham, E. M.; Vergotine, R. J.; Popova, A. P.; Flori, H. R.; Hershenson, M. B.
10.1101/2025.04.29.651288 — immunology — Posted on 2025-04-30
136 Proprioceptive and visual motion detection acuity contribute to children dynamic postural control
Iannotta, A.; Mongold, S. J.; Yldran Carlak, E.; Georgiev, C.; Cabaraux, P.; Van Dyck, D.; Naeije, G.; Van Der Ghinst, M.; Foucart, J.; Deconinck, N.; Bourguignon, M.
10.1101/2025.04.29.651175 — neuroscience — Posted on 2025-04-30
137 Comparative multi-omics profiling of Gossypium hirsutum and Gossypium barbadense fibers at high temporal resolution reveals key differences in polysaccharide composition and associated glycosyltransferases
Swaminathan, S.; Lee, Y.; Grover, C. E.; DeTemple, M. F.; Mugisha, A. S.; Sichterman, L. E.; Yang, P.; Xie, J.; Wendel, J. F.; Szymanski, D. B.; Zabotina, O. A.
10.1101/2025.04.26.650795 — plant biology — Posted on 2025-04-30
151 300 billion years of angiosperm evolution at risk of extinction
Forest, F.; Brown, R.; Buerki, S.; Colville, J. F.; Moat, J.; Lughadha, E. N.; Owen, N. R.; Raimondo, D. C.; Rivers, M.; Rosindell, J.; Walker, B. E.; Bachman, S. P.; Pipins, S.; Gumbs, R.; Brown, M. J. M.
10.1101/2025.04.29.651190 — evolutionary biology — Posted on 2025-04-30
153 Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics
Wang, J.; Montaser, A.; Sivonen, M.; Leinonen, H.; Hepojoki, J.; Ma, L.; Lehto, V.-p.; Xu, W.
10.1101/2025.02.27.640536 — immunology — Posted on 2025-04-30
155 Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice
Flerlage, W. J.; Gouty, S. C.; Thomas, E. H.; Simmons, S. C.; Tsuda, M. C.; Rujan, O.; Iyer, L.; Petrus, E. S.; Cox, B. M.; Wu, T. J.; Nugent, F. S.
10.1101/2025.04.29.651264 — neuroscience — Posted on 2025-04-30
157 Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum
Stanley, A. T.; Choi, S. J.; Frank, A.; Makowicz, E.; Cataldi, S.; Shashaank, N.; Mosharov, E. V.; Lacefield, C.; Miniaci, M.; Sulzer, D.
10.1101/2025.04.29.651089 — neuroscience — Posted on 2025-04-30
158 Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis
NyamErdene, A.; Thao Ngoc Lec, N.; Nebie, O.; Faivre, E.; Delila, L.; Chou, M. L.; Lowe, J.; Bantubungi, K.; BUEE, L.; Walker, T.; Blum, D.; Burnouf, T.
10.1101/2025.04.29.651163 — neuroscience — Posted on 2025-04-30
161 High-coverage, massively parallel sequencing of single-cell genomes with CAP-seq
Li, M.; Zhai, X.; Li, J.; Li, S.; Du, Y.; Zhang, J.; Zhang, R.; Luo, Y.; Wei, W.; Liu, Y.
10.1101/2024.09.10.612220 — genomics — Posted on 2025-04-30
162 Disentangling complex language contact and admixture in the broad Gansu-Qinghai region
Jin, H.; Tao, Y.; Yang, C.; Yang, S.; Sun, W.; Linguistic Silk Road Research Consortium, ; Xu, D.; Zhang, M.
10.1101/2025.04.28.650932 — evolutionary biology — Posted on 2025-04-30
163 Goblet cells mechanically breach the epithelial barrier in gut homeostasis
Creff, J.; He, Y.; Bernat-Fabre, S.; Buscail, E.; Neuvendel, S.; Krishnakumar, V.; Mangeat, T.; Xue, S.-L.; Krndija, D.
10.1101/2025.04.01.646617 — cell biology — Posted on 2025-04-30
164 Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimers Continuum
Chen, C.-L.; Son, S. J.; Schweitzer, N.; Jin, H.; Li, J.; Wang, L.; Yang, S.; Hong, C. H.; Roh, H. W.; Park, B.; Choi, J. W.; An, Y.-S.; Seo, S. W.; Cho, Y. H.; Hong, S.; Nam, Y. J.; Minhas, D. S.; Laymon, C. M.; Stetten, G. D.; Tudorascu, D. L.; Aizenstein, H. J.; Wu, M.; Mayo Clinic Study of Aging,
10.1101/2025.04.28.651021 — neuroscience — Posted on 2025-04-30
165 Predicting clinical phage therapy outcomes in vitro: results using mixed versus single isolates from an MRSA case study
Castledine, M.; Esom, C.; Van Nieuwenhuyse, B.; Djebara, S.; Merabishvili, M.; Pirnay, J.-P.; Buckling, A.
10.1101/2025.04.28.650979 — pathology — Posted on 2025-04-30
167 Transcriptomic analysis reveals immune signatures associated with specific cutaneous manifestations of lupus in systemic lupus erythematosus
Lee, E. Y.; Patterson, S.; Cutts, Z.; Lanata, C. M.; Dall'Era, M.; Yazdany, J.; Criswell, L. A.; Haemel, A.; Katz, P.; Ye, C. J.; Langelier, C.; Sirota, M.
10.1101/2025.04.27.649460 — bioinformatics — Posted on 2025-04-30
169 Diverse Genomic Landscape of Swine Influenza A Virus in England (2014 - 2021)
Mollett, B. C.; Byrne, A. M. P.; Everett, H. E.; Reid, S. M.; Williamson, S.; Anderson, T. K.; James, J.; Banyard, A. C.; Brown, I. H.; Lewis, N. S.
10.1101/2025.04.28.650978 — genomics — Posted on 2025-04-30
172 Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis
Nishi, K.; Sakamaki, T.; Nagasaka, A.; Kao, K. S.; Sadaoka, K.; Asano, M.; Yamamoto, N.; Takaori-Kondo, A.; Miyanishi, M.
10.1101/2024.01.18.576239 — developmental biology — Posted on 2025-04-29
174 Impact of dupilumab and upadacitinib treatment on epigenetic and transcriptomic alterations in skin-homing T cells of atopic dermatitis patients
Elfiky, A. M. I.; Smits, H. M.; van der Wal, M.; Dekkers, C.; Boesjes, C. M.; Drylewicz, J.; de Bruin-Weller, M.; van Wijk, F.
10.1101/2025.04.28.650924 — immunology — Posted on 2025-04-30
175 The reward positivity is insensitive to reinforcer devaluation
Shaffer, L. S.; Crowder, H. D.; Kakalec, P. A.; Duong, L. T.; McDonald, C. G.; Thompson, J. C.
10.1101/2025.03.27.645774 — neuroscience — Posted on 2025-04-29
177 Implantable Bioelectronics for Gut Electrophysiology
Boys, A. J.; Güemes, A. J.; Ma, L.; Gupta, R. A.; Lu, Z.; Lee, C.; El-Hadwe, S.; Carnicer Lombarte, A.; Naegele, T. E.; Uhlig, F. H.; Barone, D. G.; Bulmer, D. C.; Gelinas, J. N.; Hyland, N. P.; Khodagholy, D.; Malliaras, G. G.; Owens, R. M.
10.1101/2024.03.22.586292 — neuroscience — Posted on 2025-04-29
178 Genetic Foundations of Inter-individual Neurophysiological Variability
da Silva Castanheira, J.; Poli, J.; Hansen, J. Y.; Misic, B.; Baillet, S.
10.1101/2024.07.19.604292 — neuroscience — Posted on 2025-04-29
179 Digital Twin Brain Predicts rTMS Effects on Brain State Dynamics in Chronic Tinnitus
Zhang, J.; Han, S.; Shen, Y.; Wu, X.; Zhao, Y.; Wu, Z.; Luo, N.; Yang, Z.; Li, D.; Song, M.; Wu, P.; Tao, D.-d.; Liu, J.; Li, Y.; Jiang, T.
10.1101/2025.04.27.650883 — neuroscience — Posted on 2025-04-30
181 Reservoir Computing with Bacteria
Ahavi, P.; Hoang, A.; Meyer, P.; Berthier, S.; Fiorini, F.; Castelli, F.; Epaulard, O.; Le Gouellec, A.; Faulon, J.-L.
10.1101/2024.09.12.612674 — systems biology — Posted on 2025-04-29
182 Prenatal exposure to dietary levels of glyphosate disrupts metabolic, immune, and behavioral markers across generations in mice.
Barnett, J. A.; Josephson, J. K.; Haskey, N. A.; Hart, M. M.; Soma, K. K.; Verdugo, A.; McComb, C. J.; Bandy, M. L.; Ghosh, S.; Letef, C.; Copp, A.; Ishida, R.; Yuzbashian, E.; Gibon, J.; Ye, J.; Giebelhaus, R. T.; Murch, S. J.; Jung, M. M.; Gibson, D. L.
10.1101/2024.08.27.609990 — pharmacology and toxicology — Posted on 2025-04-29
183 Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer
Sar, F.; Chung, H. C.; Lin, Y.-Y.; Lin, D.; Morova, T.; Haegert, A.; Volik, S.; Bell, R.; LeBihan, S.; Ozturan, D.; Xue, H.; Dong, X.; Wu, R.; Li, J.; Kung, H.-J.; Gleave, M. E.; Lack, N. A.; Wang, Y.; Collins, C. C.
10.1101/2025.04.25.650369 — cancer biology — Posted on 2025-04-29
186 Structure-enabled enzyme function prediction unveils elusive terpenoid biosynthesis in archaea
Samusevich, R.; Hebra, T.; Bushuiev, R.; Engst, M.; Kulhanek, J.; Bushuiev, A.; Smith, J. D.; Calounova, T.; Smrckova, H.; Molineris, M.; Schwartz, R.; Tajovska, A.; Perkovic, M.; Chatpatanasiri, R.; Kampranis, S. C.; Major, D. T.; Sivic, J.; Pluskal, T.
10.1101/2024.01.29.577750 — biochemistry — Posted on 2025-04-29
187 Additive and substitutable prey responses to feral and native predator combinations.
St. Juliana, J. R.; Bleicher, S. S.; Mukherjee, S.; Sundararaj, V.; Brown, J. S.; Kotelr, B. P.
10.1101/2024.09.09.612031 — animal behavior and cognition — Posted on 2025-04-29
188 Detection of sex chromosomes in Tephritid pests using R-CQ and KAMY, two computational methods to enable species specific control.
Rallis, D.; Tsoumani, K. T.; Krsticevic, F.; Papathanos, P. A.; Gouvi, G.; Meccariello, A.; Mathiopoulos, K. D.; Papanicolaou, A.
10.1101/2023.10.27.564325 — genomics — Posted on 2025-04-29
189 Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
Bidard, F.; Grognet, P.; Lelandais, G.; Imbeaud, S.; Mucchielli-Giorgi, M. H.; Debuchy, R.; Berteaux-Lecellier, V.; Malagnac, F.
10.1101/2024.12.09.627484 — genomics — Posted on 2025-04-29
190 Joint profiling of cell morphology and gene expression during in vitro neurodevelopment
Sundaresh, A.; Meistermann, D.; Lampela, R.; Yang, Z.; Woldegebriel, R.; Ganna, A.; Costa, P. P.; Kilpinen, H.
10.1101/2023.12.03.569583 — genomics — Posted on 2025-04-29
191 Platform-dependent effects of genetic variants on plasma APOL1
Wang, Q. S.; Huang, J.; Chan, L.; Haste, N.; Olsson, N.; Gaun, A.; McAllister, F.; Madhireddy, D.; Baruch, A.; Cardone, K. M.; Kumar, R.; Ritchie, M.; Susztak, K.; Melamud, E.; Baryshnikova, A.
10.1101/2025.01.30.635763 — genetics — Posted on 2025-04-29
193 Genomics and reproductive biology of Leptopilina n. sp. Buffington, Lue, Davis & Tracey sp. nov. (Hymenoptera: Figitidae): An asexual parasitoid of Caribbean Drosophila
Lindsey, A. R.; Lue, C.-H.; Davis, J. S.; Borjon, L. J.; Mauthner, S. E.; Fricke, L. C.; Eads, L.; Murphy, M.; Drown, M. K.; Faulk, C.; Buffington, M. L.; Tracey, W. D.
10.1101/2025.03.28.645512 — evolutionary biology — Posted on 2025-04-29
200 CCDC32 stabilizes clathrin-coated pits and drives their invagination
Yang, Z.; Yang, C.; Huang, Z.; Xu, P.; Li, Y.; Han, L.; Peng, L.; Wei, X.; Pak, J.; Svitkina, T.; Schmid, S. L.; Chen, Z.
10.1101/2024.06.26.600785 — cell biology — Posted on 2025-04-29
203 Universal rules govern plasmid copy number
Ramiro-Martinez, P.; de Quinto, I.; Gama, J. A.; Rodriguez-Beltran, J.
10.1101/2024.10.04.616648 — microbiology — Posted on 2025-04-29
205 ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain
von Maydell, D.; Wright, S.; Pao, J.; Staab, C.; King, O.; Spitaleri, A.; Bonner, J. M.; Liu, L.; Yu, C. J.; Chiu, C.-C.; Leible, D.; Scannail, A. N.; Li, M.; Boix, C. A.; Mathys, H.; Leclerc, G.; Menchaca, G. S.; Welch, G.; Graziosi, A.; Leary, N.; Samaan, G.; Kellis, M.; Tsai, L.-H.
10.1101/2023.09.05.556135 — neuroscience — Posted on 2025-04-29
207 Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells
Zhao, T.; He, L.; Wong, L. P.; Mei, S.; Xia, J.; Xu, Y.; Van Vranken, J.; Mazzola, M.; Chen, L.; Rhee, C.; Fang, T.; Fukushima, T.; Sayles, L.; Diaz, M.; Gibbons, J. A. B.; Mostoslavsky, R.; Gygi, S. P.; Dou, Z.; Sykes, D. B.; Sadreyev, R.; Sweet-Cordero, A.; Scadden, D. T.
10.1101/2025.04.25.650293 — cancer biology — Posted on 2025-04-29
210 Deep contrastive learning enables genome-wide virtual screening
Jia, Y.; Gao, B.; Tan, J.; Zheng, J.; Hong, X.; Zhu, W.; Tan, H.; Xiao, Y.; Tan, L.; Cai, H.; Huang, Y.; Deng, Z.; Wu, X.; Jin, Y.; Yuan, Y.; Tian, J.; He, W.; Ma, W.; Zhang, Y.; Zhang, W.; Liu, L.; Yan, C.; Lan, Y.
10.1101/2024.09.02.610777 — bioinformatics — Posted on 2025-04-29
211 Massively parallel characterization of RNA G-quadruplex stability and molecular recognition
Martyr, J. G.; Guzman, B. B.; Hu, Y.; Rothacher, R. L.; Mustoe, A. M.; Aleman, M. M.; Dominguez, D.
10.1101/2025.04.29.651304 — biochemistry — Posted on 2025-04-29
212 Differential effects of chronic restraint stress on two active avoidance tasks in rats
Lopez-Moraga, A.; De Ceuninck, M.; Van der Heyden, Y.; Vercammen, L.; Palme, R.; Vervliet, B.; Beckers, T.; Luyten, L.
10.1101/2025.02.28.640742 — animal behavior and cognition — Posted on 2025-04-29
214 Transposable elements are vectors of recurrent transgenerational epigenetic inheritance in nature
Baduel, P.; De Oliveira, L.; Caillieux, E.; Bohl-Viallefond, G.; Xu, C.; El Messaoudi, M.; Barois, M.; Singh, V.; Sarazin, A.; Teixeira, F. K.; Boccara, M.; Gilbault, E.; de France, A.; Quadrana, L.; Loudet, O.; Colot, V.
10.1101/2024.09.20.614076 — genomics — Posted on 2025-04-29
215 Demographic history explains mitochondrial genome capture and mitonuclear discordance among South American collared Tropidurus lizards
Salles, M. M. A.; Carvalho, A. L. G.; Leache, A. D.; Martinez, N.; Bauer, F.; Motte, M.; Espinola, V.; Rodrigues, M. T.; Piantoni, C.; Pie, M. R.; Olivotto, A.; Colli, G. R.; Choueri, E. L.; Werneck, F. P.; Domingos, F. M. C. B.
10.1101/2025.04.25.650633 — genomics — Posted on 2025-04-29
217 Exogenous dsRNA made accessible to Dicer by two eukaryotic RNA-dependent RNA polymer-ases
Pirritano, M.; Buescher, J.; Staubach, P.; Tacken, T.; Yakovleva, Y.; Sabura, M.; Shehu, K.; Franzenburg, S.; Schneider, M.; Simon, M.
10.1101/2025.04.26.650694 — genetics — Posted on 2025-04-29
219 An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth
Xiao, W.; Yang, L.; Ji, H.; Molina, D.; Chen, H.; Yu, S.; Miao, Y.; Ripper, D.; Deng, S.; Bayer, M.; De Rybel, B.; Ragni, L.
10.1101/2024.06.20.599823 — plant biology — Posted on 2025-04-29
221 Phosphorus fertility regulates microbial carbon use efficiency and SOM decomposition in non-allophanic Andosols
KOIZUMI, W.; CLOUGH, T. J.; KOJIMA, S.; MAKINO, T.; SUGIHARA, S.; TAJIMA, R.; UCHIDA, Y.; HAMAMOTO, T.
10.1101/2025.04.29.651165 — biochemistry — Posted on 2025-04-29
223 Typhoid toxin of Salmonella enterica induces ISG15 response mediating host cell survival and bacterial dissemination
Stark, D. S.; King, M.; Ibler, A. E.; Baseer, N.; Vernon, E. G.; Zhang, Y.; Staples, C.; Radoshevich, L.; Humphreys, D.
10.1101/2025.04.29.649991 — microbiology — Posted on 2025-04-29
225 Effects of Willow and Pine tree growth in bacterial abundance, interactions and metabolic profile in a copper mine tailing
Ortega, J.; Galvez, G.; Serrano, G.; Torres, J.; Aliaga-Tobar, V.; Vilches, E.; Reyes, A.; Maracaja-Coutinho, V.; Parra, V.; Di Genova, A.; Pizarro, L.; Latorre, M.
10.1101/2025.04.28.651128 — microbiology — Posted on 2025-04-29
227 CertPrime: a new oligonucleotide design tool for gene synthesis
Luna-Cerralbo, D.; Serrano, A.; Blasco-Machin, I.; Hamdan, F.; Martinez-Olivan, J.; Broset, E.; Bruscolini, P.
10.1101/2025.04.29.650686 — synthetic biology — Posted on 2025-04-29
228 Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA
Gamas, K. R.; Seamons, T.; Dysart, M.; Fang, L.; Chappell, J.; Stadler, L.; Silberg, J.
10.1101/2025.04.29.651329 — synthetic biology — Posted on 2025-04-29
232 SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
Lehmkuhl, I.; Amin, K.; Hampel, N.; Iram, A.; Hesse, J.; Wiek, C.; Nguyen, J. T. V.; Hanenberg, H.; Scheller, J.; Ahmadian, M. R.; Stork, B.; Floss, D. M.; Piekorz, R. P.
10.1101/2025.04.29.649368 — biochemistry — Posted on 2025-04-29
237 Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs
Arends, D.; Ashbrook, D. G.; Roy, S.; Lu, L.; Sloan, Z. A.; Centeno, A. G.; Lamour, K. H.; de Magalhaes, J. P. W.; Prins, P.; Broman, K. W.; Sen, S.; Mitchell, S. J.; MacArthur, M. R.; Akin, O. A.; Auwerx, J.; Bajwa, A.; Harrison, D. H.; Strong, R.; Nelson, J. F.; Mozhui, K.; Williams, E. G.; Miller, R. A.; Williams, R. W.; Diaz, V.
10.1101/2025.04.27.649857 — genetics — Posted on 2025-04-29
240 mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract
Hazell, N. C.; Reyna, R. A.; Bonam, S. R.; Bei, J.; Kumar, N.; Nguyen, T. N.; Plante, J. A.; Walker, D. H.; Wang, T.; Plante, K. S.; Hu, H.
10.1101/2025.04.28.650951 — microbiology — Posted on 2025-04-29
241 Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5
Galais, M.; HERLEM, G.; HAIDAR AHMAD, S.; Pasquereau, S.; EL BABA, R.; BELLEFROID, M.; PLANT, E.; MOROT-BIZOT, S.; PICAUD, F.; HERBEIN, G.; Van Lint, C. M.
10.1101/2025.04.28.650947 — microbiology — Posted on 2025-04-29
243 Methylene Blue-Photodynamic Therapy Effectively Kills Antibiotic-Resistant Bacteria from Pediatric Patients with Perforated Appendicitis
Wirth, K. T.; Wang, E. Y.; Hawryluk, D. S.; Byrne, M. M.; Arca, M. J.; Wakeman, D. S.; Pegoli, W.; Darcy, D. G.; Pavelka, M. S.; Wilson, N. A.; Baran, T. M.
10.1101/2025.04.29.651230 — microbiology — Posted on 2025-04-29
244 Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs
Merino, F.; Koeck, Z.; Ermel, U. H.; Dahlhaus, P.; Grimm, A.; Seybert, A.; Kubicek, J.; Frangakis, A. S.; Doetsch, V.; Hilger, D.; Bernhard, F.
10.1101/2025.04.29.651181 — biochemistry — Posted on 2025-04-29
245 Nucleosome context regulates chromatin reader preference
Marunde, M. R.; Popova, I. K.; Hall, N. W.; Vaidya, A.; Bone, J. R.; Boone, B. A.; Brown, P. J.; Ezell, R. J.; Firestone, T. M.; Fuchs, H. A.; Gibson, E.; Gillespie, Z. B.; Gloor, S. L.; Hickman, A. R.; Howard, S. A.; Husby, N. L.; Hsiung, V. T.; Johnstone, A. L.; Khan, L. F.; Krajewski, K.; Lee, A. S.; McAnarney, E. T.; Maier, K. E.; Maryanski, D. N.; Noll, K. E.; Novitzky, K.; Patteson, E. F.; Rodriguez, K. L.; Sanchez, J. C.; Schachner, L. F.; Smith, C. E.; Sun, L.; Taylor, H. F.; Watson, R.; Willis, H. E.; Musselman, C. A.; Venters, B. J.; Cheek, M. A.; Meiners, M. J.; Sun, Z.-W.; Kelleher
10.1101/2025.04.29.651129 — biochemistry — Posted on 2025-04-29
247 Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis
Chen, S.; Markett, D.; Karimzadeh, M.; Luo, Y.; Khoroshkin, M. S.; Boyraz, B.; Lee, S.; Carpenter, C.; Nguyen, P.; Garcia, K.; Joshi, T.; Martin, C.; Hanisch, B.; Molina, H.; Tavazoie, S.; Ramani, V.; Navickas, A.; Goodarzi, H.
10.1101/2025.04.26.650725 — genomics — Posted on 2025-04-29
248 Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway
Wang, Y.; Cope, O.; Chen, J.; Mehta, A.; Fleifel, D.; Ford, C.; Benhamie, P.; Haase, S.; Gulec, S.; Elston, T.; Spanheimer, P. M.; Tomblin, C. A.; Rojas, A.; Tate, T.; Purvis, J.; Wang, J. R.; Dahl, J. M.; Wolff, S. C.; Cook, J.; Brunk, E. C.
10.1101/2025.04.26.650733 — genomics — Posted on 2025-04-29
250 Type I interferons enhance human dorsal root ganglion nociceptor excitability and induce TRPV1 sensitization
Franco-Enzastiga, U.; Natarajan, K.; Espinosa, F.; Granja-Vazquez, R.; Mydugolam, H.; Price, T. J.
10.1101/2025.04.22.650068 — neuroscience — Posted on 2025-04-29
252 Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis
Nguyen, C. V.; Martija, A.; Nano, P. R.; Soto, J. A.; Jaklic, D. C.; Mil, J.; White, R.; Martin, J. M.; Rana, D.; Geschwind, D. H.; Bhaduri, A.
10.1101/2025.04.25.650717 — neuroscience — Posted on 2025-04-29
254 Effect of Transcranial Light Stimulation on the Neurovascular Unit in the Human Brain
Zhao, C.; Li, Z.; Ding, Z.; Zhang, K.; Li, Y.; Zhang, L.; Zou, Q.; Gao, Z.; Cui, Z.; Li, X.
10.1101/2025.04.23.649937 — neuroscience — Posted on 2025-04-29
255 Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State
Lee, C. R.; Matthews, G. A.; Lemieux, M. E.; Wasserlein, E. M.; Borio, M.; Miranda, R. L.; Keyes, L. R.; Schneider, G. P.; Jia, C.; Tran, A.; Aloboudi, F.; Chan, M. G.; Peroni, E.; Pereira, G. S.; Lopez-Moraga, A.; Palle, A.; Kimchi, E. Y.; Padilla-Coreano, N.; Wichmann, R.; Tye, K. M.
10.1101/2025.02.03.636224 — neuroscience — Posted on 2025-04-29
257 A Cross-Species Generative Cell Atlas Across 1.5 Billion Years ofEvolution: The TranscriptFormer Single-cell Model
Pearce, J. D.; Simmonds, S. E.; Mahmoudabadi, G.; Krishnan, L.; Palla, G.; Istrate, A.-M.; Tarashansky, A.; Nelson, B.; Valenzuela, O.; Li, D.; Quake, S. R.; Karaletsos, T.
10.1101/2025.04.25.650731 — systems biology — Posted on 2025-04-29
258 Orbitofrontal Cortex Influences Dopamine Dynamics Associated with Alloparental Behavioral Acquisition in Female Mice
Tasaka, G.-i.; Hagihara, M.; Irie, S.; Kobayashi, H.; Inada, K.; Kobayashi, K.; Kato, S.; Kobayashi, K.; Miyamichi, K.
10.1101/2023.02.03.527077 — neuroscience — Posted on 2025-04-29
259 Non-duality in brain and experience of advanced meditators - Key role for Intrinsic Neural Timescales
Malipeddi, S.; Sasidharan, A.; Ventura, B.; Venugopal, R.; Bauer, C. C.; Tewarie, P. K. B.; Ravindra, P. N.; Mehrotra, S.; John, J. P.; Subramaniam, B.; Laureys, S.; Kutty, B. M.; Northoff, G.
10.1101/2025.04.21.649758 — neuroscience — Posted on 2025-04-29
260 Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis
Weaver, R. R.; Gray, A. L.; Mateus-Gomes, S.; Ridley, A. J.; Giblin, S. P.; Birchenough, H. L.; Peterson, F. C.; Mulholland, I. Z.; Lowe, K. O.; Schiessl, I.; Jowitt, T. A.; Pease, J. E.; Banks, W. A.; Rua, R.; Erickson, M. A.; Dyer, D. P.
10.1101/2025.04.23.650173 — neuroscience — Posted on 2025-04-29
261 Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals
Stewart, C.; Liddle, T. A.; Tolla, E.; Lewis, J. E.; Marshall, C.; Evans, N. P.; Morgan, P. J.; Ebling, F. J.; Stevenson, T. J.
10.1101/2025.04.22.650143 — neuroscience — Posted on 2025-04-29
262 Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Dolan, M.-J.; Rakosi-Schmidt, R.; Garcia, E.; Lin, Y.; Nadaf, N. M.; Dixon, J.; Guo, S.; Morshed, N.; Depp, C.; Doman, J.; Xia, J.; Jäntti, H.; Stevens, B.; Macosko, E. Z.
10.1101/2025.04.22.649486 — neuroscience — Posted on 2025-04-29
267 Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice
Yao, M.; Sun, N.; Linville, R.; Wei, Z.; Kakazu, A.; Ouyang, Y.; Li, R.; Du, L.; Wang, H.; Zhou, Y.; Jiang, Y.; Zhang, Z.; Li, A.; Lu, H.; Xu, J.; Kellis, M.; Heiman, M.; Duan, W.
10.1101/2025.04.23.650260 — neuroscience — Posted on 2025-04-29
268 Telmisartan and Lisinopril Show Potential Benefits in Rescuing Cognitive-Behavioral Function Despite Limited Improvements in Neuropathological Outcomes in Tg-SwDI Mice
Motzko Noto, N.; Restrepo, Y. M.; Hernandez, A.; Vogel, C.; Pulido-Correa, V.; Moen, S.; Bonetti, J.; Chiduruppa, V.; Speth, R. C.; Robison, L. S.
10.1101/2025.04.23.650226 — neuroscience — Posted on 2025-04-29
271 Telomerase RNA gene duplications drive telomeric repeatdiversity and evolution in Andrena bees
Klapproth, C.; Israel, E.; Ahmed, A.; Remmel, A.; Kaether, K.-K.; Reinhardt, F.; Chen, J. J. L.; Prohaska, S. J.; Steidle, J.; Lemke, S.; Stadler, P. F.; Findeiss, S.
10.1101/2025.04.29.651168 — bioinformatics — Posted on 2025-04-29
272 Demographic history explains mitochondrial genome capture and mitonuclear discordance among South American collared Tropidurus lizards
Salles, M. M. A.; Carvalho, A. L. G.; Leache, A. D.; Martinez, N.; Bauer, F.; Motte, M.; Espinola, V.; Rodrigues, M. T.; Piantoni, C.; Pie, M. R.; Olivotto, A.; Colli, G. R.; Choueri, E. L.; Werneck, F. P.; Domingos, F. M. C. B.
10.1101/2025.04.25.650633 — genomics — Posted on 2025-04-29
273 LOSS OF ROR2 TYROSINE KINASE RECEPTOR IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PAH VIA INAPPROPRIATE INTEGRIN BETA 1 ACTIVATION
Mitra, A.; Chakraborty, A.; Zhong, B.; Heo, L.; Agarwal, S.; Pacheco, A.; Auer, N.; Dunn, A.; Chelladurai, P.; Jain, A.; Matos, J.; Bankar, A.; Guardado, E.; YI, D.; Zhao, H.; Wai Dede Man, K.; Nair, R. V.; Guenat, O. T.; Dai, Z.; de Jesus Perez, V. A.
10.1101/2025.04.28.651135 — cell biology — Posted on 2025-04-29
275 Estimating fMRI Timescale Maps
Riegner, G.; Davenport, S.; Voytek, B.; Schwartzman, A.
10.1101/2025.04.23.650300 — neuroscience — Posted on 2025-04-29
278 Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity
Pant, T.; Jiang, C.; Yan, Y.; Schultz, B.; Laws, D.; Logan, S.; Bedrat, A.; Juric, M.; Berens, R. J.; Taylor, S. P.; Henry, A. M.; Bosnjak, Z. J.; Bai, X.
10.1101/2025.04.23.650256 — neuroscience — Posted on 2025-04-29
279 Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders
Kurganov, E.; Cui, L.; Budnik, N.; Chen, S.; Olivares, E.; Baez-Nieto, D.; Lusk, L.; Smith, L.; Jo, S.; Mullegama, S. V.; Lindy, A.; George, A. L.; Poduri, A.; Helbig, I.; Daly, M.; Pan, J. Q.
10.1101/2025.04.23.650298 — neuroscience — Posted on 2025-04-29
280 Excitation-Inhibition Balance and Fronto-Limbic Connectivity Drive TMS Treatment Outcomes in Refractory Depression
Momi, D.; Wang, Z.; Oveisi, M. P.; Kadak, K.; Bastiaens, S. P.; Lissemore, J. I.; Noda, Y.; Downar, J.; Vila Rodriguez, F.; Strafella, R.; Daskalakis, Z. J.; Zrenner, C.; Zomorrodi, R.; Rolle, C. E.; Saggar, M.; Williams, N.; Keller, C. J.; Blumberger, D. M.; Voineskos, D.; Griffiths, J. D.
10.1101/2025.04.23.648963 — neuroscience — Posted on 2025-04-29
282 A New Serological Autoantibody Signature Associated with Multiple Sclerosis
Abdesselem, H. B.; Van Benthem, A. D.; Bensmail, I.; Elbashir, I. E.; Tan, T.-M.; Abylova, B.; Koon, L.; Anuar, D.; Blackburn, J. M.; Malik, R. A.; Petropoulos, I. N.
10.1101/2025.04.23.650160 — neuroscience — Posted on 2025-04-29
283 Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent Mechanism
Chandrashekar, A.; Xu, Y.; Ma, X.; Yauch, A. K.; Scholl, E.; Yang, Y.; Gada, K. D.; Kawano, T.; Cui, M.; Plant, L. D.
10.1101/2025.04.25.650734 — physiology — Posted on 2025-04-29
284 Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.
Patton, M. E.; Kelekar, S.; Taylor, L. J.; Dean, A. E.; Zuo, Q.; Thakare, R. N.; Lee, S. H.; Gentry, E.; Panitchpakdi, M.; Dorrestein, P.; Alnouti, Y.; Madak-Erdogan, Z.; Lee, J.-S.; Finegold, M. J.; Anakk, S.
10.1101/2020.06.25.172635 — cancer biology — Posted on 2025-04-29
285 NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck Cancer
Huang, C.; Moorthy, S.; Li, Q.; Ahmed, K. M.; Deng, D.; Wang, J.; Rao, X.; Zhang, J.; Xi, Y.; Wang, J.; Liu, Z.; Tanaka, N.; Wheeler, D. A.; Shibrot, E.; Saade, R.; Pickering, C. R.; Xie, T.-X.; El-Naggar, A. K.; Osman, A. A.; Rai, K.; Zweidler-McKay, P. A.; Heymach, J. V.; Byers, L. A.; Johnson, F. M.; Sandulache, V. C.; Myers, J. N.; Yadollahi, P.; Frederick, M. J.
10.1101/2025.04.25.650710 — cancer biology — Posted on 2025-04-29
288 Microengineered transplantation of human solid tumors for in vitro studies of CAR T immunotherapy
Liu, H.; Noguera-Ortega, E.; Dong, X.; Lee, W. D.; Chang, J.; Aydin, S. A.; Li, Y.; Shin, Y.; Shi, X.; Liousia, M.; Martinez, M.; Brotman, J.; Kim, S.; Chen, Z.; Wang, A.; Ou, Z.; Paek, J.; Park, J. Y.; Liu, A.; Hu, H.; Xiao, Z.; Racca, D. M.; Kim, S.-j.; Worthen, G. S.; Guo, W.; Pure, E.; Kang, T.; Rabinowitz, J.; Wherry, E. J.; Moon, E.; Albelda, S.; Huh, D. D.
10.1101/2025.04.25.650709 — bioengineering — Posted on 2025-04-29
293 Functional Dissection of the Zdhhc5-GOLGA7 Protein Palmitoylation Complex
Kahlson, M. A.; Ritho, J.; Gomez, J. V.; Wang, H.; Butterwick, J.; Dixon, S. J.
10.1101/2025.04.28.651057 — biochemistry — Posted on 2025-04-29
294 A large global soil carbon sink informed by repeated soil samplings
Jia, R.; Fricke, E.; Malhotra, A.; Bar-On, Y. M.; Deng, J.; Pineiro, G.; Bazzoni, B.; Alvarez, R.; Findlay, N.; te Beest, M.; Zhou, Y.; Boutton, T. W.; Dar, J. A.; Kothandaraman, S.; MacDougall, A. S.; Eisenhauer, N.; Peri, P. L.; Zheng, J.; Power, S. A.; Reed, S. C.; Macek, P.; Haider, S.; Sitch, S.; O'Sullivan, M.; Friedlingstein, P.; Bond-Lamberty, B.; Hungate, B.; Jackson, R. B.; Subramanian, M.; Patel, K.; Terrer, C.
10.1101/2025.04.25.650716 — ecology — Posted on 2025-04-29
295 VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment
Calderon, R. I.; Sah, N.; Huang, M.; Kittle, R. H.; Shaik, W.; Chousal, J. N.; Kallol, S.; Bui, T.; Morey, R.; Mitre, A.; Fogarty, N. M. E.; Gerri, C.; Zheng, C.; DeHoff, P. M.; Home, P.; Niakan, K.; Cook-Andersen, H.; Fisch, K. M.; Paul, S.; Soncin, F.
10.1101/2025.04.25.650693 — developmental biology — Posted on 2025-04-29
298 Myo1e/f at the podosome base regulate podosome dynamics and promote macrophage migration
Cervero, P.; Barger, S. R.; Verdys, P.; Herzog, R.; Paul, T.; Palmieri, M.; Poincloux, R.; Linder, S.; Krendel, M.
10.1101/2025.04.28.651090 — cell biology — Posted on 2025-04-29
299 Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition of Laminin in Mammals
Miner, J. H.; Omachi, K.; Yurchenco, P.; McKee, K. K.; Lin, M.-H.; Fujiwara, H.; Puapatanakul, P.
10.1101/2025.04.28.650774 — cell biology — Posted on 2025-04-29
300 ARAP2 regulates responses to interferon-gamma by restricting SOCS1
Keating, N.; Doggett, K.; Bidgood, G.; Guzman, L. G. M.; Dagley, L.; Li, K.; Gabrielyan, A.; Alvarado, C.; Williams, B.; Broomfield, B.; Duckworth, B.; Hockings, C.; Youssef, J.; Leong, E.; Morris, R.; Kueh, A.; Garnham, A.; Casanova, J.-L.; Boisson-Dupuis, S.; Babon, J.; Linossi, E.; Tate, M. D.; Groom, J. R.; Nicholson, S.
10.1101/2025.04.28.650977 — cell biology — Posted on 2025-04-29
301 Condensin I confers Stiffness and Centromeric Cohesion to Mitotic Chromosomes
Nielsen, C. F.; Witt, H.; Ridolfi, A.; Kempers, B.; Chameau, E. M. J.; van der Smagt, S.; Barisic, M.; Peterman, E. J. G.; Wuite, G. J. L.; Hickson, I. D.
10.1101/2025.04.29.651176 — cell biology — Posted on 2025-04-29
302 A genome-scale CRISPR deletion screen in Chinese Hamster Ovary cells reveals essential regions of the coding and non-coding genome
De Marco, F.; Sebastian, I. R.; Napoleone, A.; Molin, A.; Riedl, M.; Bydlinski, N.; Motheramgari, K.; Hussein, M.; Kramer, L.; Kelly, T.; Jostock, T.; Borth, N.
10.1101/2025.04.28.650989 — cell biology — Posted on 2025-04-29
303 Representational dynamics during extinction of fear memories in the human brain
Pacheco-Estefan, D.; Bouyeure, A.; Jacobs, G.; Fellner, M.- C.; Lehongre, K.; Lambrecq, V.; Frazzini, V.; Navarro, V.; Gunturkun, O.; Shen, L.; Yang, J.; Han, B.; Chen, Q.; Axmacher, N.
10.1101/2025.04.26.650560 — neuroscience — Posted on 2025-04-29
304 SnRK1.1 Coordinates Organ-Specific Growth-Defense Programs via Transcriptomic Rewiring in Arabidopsis thaliana
Kalachova, T.; Muller, K.; Lacek, J.; Pree, S.; Antonova, A.; Bondarenko, O.; Burketova, L.; Retzer, K.; Weckwerth, W.
10.1101/2025.04.25.650715 — plant biology — Posted on 2025-04-29
307 Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
Zhang, Y.; Xu, M.; Yuan, J.; Hu, Z.; Jiang, J.; Sun, Y.; Huang, J.; Wang, Y.; Wang, B.; Shen, J.; Long, M.; Fan, Y.; Montone, K. T.; Tanyi, J.; Kim, S. H.; Tavana, O.; Vonderheide, R. H.; Chan, H. M.; Domchek, S. M.; Hu, X.; Zhang, L.
10.1101/2024.05.21.595159 — cancer biology — Posted on 2025-04-29
308 Distinct druggable biological processes in early-onset prostate cancer
Schmidt, S.; Jarai, Z.; Larkeryd, A.; Ozer, B.; Karlsson, Q.; Campbell, J.; Merson, S.; Dennis, N.; Hazell, S.; Mitsopoulos, C.; Cooper, C.; ICGC-UK, T.; Consortium, T.; Russell, K.; Workman, P.; Eeles, R.; Al-Lazikani, B.
10.1101/2025.04.25.650707 — cancer biology — Posted on 2025-04-29
310 Identification of the Best Filter-based Feature Selection Techniques for Microarray Datasets
Islam, A.; Bhadra, T.; Mali, K.; Giri, J.; Aurangzeb, K.; Budhathoki, R. K.; Mallik, S.
10.1101/2025.04.25.650719 — bioinformatics — Posted on 2025-04-29
311 Robotic performance is comparable to human operators for cell therapy manufacturing tasks
Sadhu, S.; Schmittlein, B.; Lares, A.; Nayak, S.; Uboldi, M.; Yu, Y.; Wang, J.; Zhang, W.; Bhanap, P. P.; Ji, Y.; Scheffler, A.; Wilson, J.; Welch, D.; Gkitsas-Long, N.; Retherford, A. J.; Melocchi, A.; Parietti, F.; Feldman, S. A.; Esensten, J. H.
10.1101/2025.04.25.650551 — bioengineering — Posted on 2025-04-29
314 Short-term gonadal cultures are sufficient for germline transmission in a songbird
Biegler, M. T.; Harter, E.; Sidhu, A. V.; Szialta, C.; Durham, G.; Tchernichovski, L.; Collier, P.; Luo, J.-D.; Wang, W.; MacIsaac, R.; Belay, K.; Carroll, T.; Keyte, A. L.; Jarvis, E. D.
10.1101/2025.04.25.650428 — developmental biology — Posted on 2025-04-29
317 Brainstem sensing of multiple body signals during food consumption
Essner, R. A.; Ruda, K.; Choh, H. J.; Kucukdereli, H.; Amsalem, O.; Edelhaus, J.; Grodem, S.; Lensjo, K. K.; Lever, T. E.; Andermann, M. L.
10.1101/2025.04.28.651046 — neuroscience — Posted on 2025-04-29
318 Early visual experience elicits cellular and functional plasticity in the retina and alters behaviour
Reynolds, P.; Marchi, D.; Ling, Y. T.; Slangewal, K.; Capelle, M.; Chalakova, Z.; Bahl, A.; Hindges, R.
10.1101/2025.04.29.651180 — neuroscience — Posted on 2025-04-29
319 Achieving cell-type specific transduction with adeno-associated viral vectors in pigeons
Tuff, J. M.; Haselhuhn, K.; Surdin, T.; Herlitze, S.; Ziegler, M.; Guentuerkuen, O.; Rook, N.
10.1101/2025.04.29.651184 — neuroscience — Posted on 2025-04-29
320 PIBE: Parallel ion beam etching of sections collected on wafer for ultra large-scale connectomics
Ma, H.; Lv, Y.; Wang, M.; Zhao, Z.; Zhang, L.; Chang, S.; Liu, J.; Chen, B.; Dong, X.; Zhang, Y.; Guo, J.; Chen, H.; Zhai, H.; Li, L.; Chen, X.; Han, H.
10.1101/2025.04.25.650569 — neuroscience — Posted on 2025-04-29
321 Cardiac interoception impacts behavior and brain-wide neuronal dynamics
Herrera, K. J.; Zarghani-Shiraz, A.; Ahrens, M. B.; Engert, F.; Fishman, M. C.
10.1101/2025.04.25.650721 — neuroscience — Posted on 2025-04-29
322 Analysing the Role of KIN10 in Directional Root Growth Regulation in Arabidopsis thaliana
Retzer, K.; Garcia-Gonzalez, J.; Muller, K.; Lacek, J.; Pree, S.; Friedl, N.; Weckwerth, W.
10.1101/2025.04.25.650732 — plant biology — Posted on 2025-04-29
324 In-cell discovery and characterization of a non-canonical bacterial protein translocation-folding complex
Jensen, R. K.; Xue, L.; Marotta, F.; Somody, J. C.; Selkrig, J.; Lenz, S.; Rappsilber, J.; Savitski, M. M.; Kosinski, J.; Typas, A.; Zimmermann-Kogadeeva, M.; Bork, P.; Mahamid, J.
10.1101/2025.04.25.650208 — molecular biology — Posted on 2025-04-25
325 Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions
Bakker, R. A.; Nicholson, O. B.; Park, H.; Xiao, Y.-L.; Tang, W.; Subramaniam, A. R.; Lapointe, C. P.
10.1101/2025.04.11.648485 — molecular biology — Posted on 2025-04-25
332 Suppression of nonsense mutations by small, cyclic peptides
Birkmose, N.; Bhat, S. Y.; Bhatthacharya, A.; Hansen, P. R.; Andersen, T. G.; Hunter, S.; Larsen, E. T.; Goldman, Y.; Cooperman, B. S.; Knudsen, C. R.
10.1101/2025.04.25.650553 — molecular biology — Posted on 2025-04-26
335 Cellular and Molecular Resolution of Focal Segmental Glomerulosclerosis Recurrence in Human Allografts
Gallon, L.; Zubair, H.; Rousselle, T. V.; Shetty, A. C.; Azim, S.; Bardhi, E.; Forte, E.; Drachenberg, C. B.; Akalin, E.; Talwar, M.; Bromberg, J. S.; Maluf, D. G.; Mas, V. R.
10.1101/2025.04.24.650454 — molecular biology — Posted on 2025-04-26
336 Phage lysis protein LysM acts as a wedge to block MurJ conformational changes
Kohga, H.; Lertpreedakorn, N.; Miyazaki, R.; Wu, S.; Tanaka, H.; Takahashi, Y. S.; Hosoda, K.; Yoshikaie, K.; Kuruma, Y.; Shigematsu, H.; Mori, T.; Tsukazaki, T.
10.1101/2025.04.26.650401 — molecular biology — Posted on 2025-04-26
337 Identification of HIV Tat and NF-κB binding proteins associated with semen-derived extracellular vesicles
Okeoma, B. C.; Kaddour, H.; Naushad, W.; Paromov, V.; Chaudhary, A.; Noghero, A.; Stapleton, J. T.; Okeoma, C. M.
10.1101/2025.04.25.650599 — molecular biology — Posted on 2025-04-26
338 Single cell mapping of the human endometrium and first trimester decidua identifies distinct epithelial and stromal cell contributions to fertility
Burns, G. W.; Paul, E.; Persaud, M.; Zhao, Q.; Li, R.; Blackledge, K.; Garcia de Paredes, J.; Shukla, P.; Arora, R.; Chemerinski, A.; Douglas, N.
10.1101/2025.04.24.650488 — molecular biology — Posted on 2025-04-26
342 Mouse Bio-behavioral Phenotyping Using a Digital Homecage Framework for Long-timescale, High-resolution, and Multi-factor Data Collection and Analytics
Ognjanovski, N.; Ghimire, A.; Hale, P.; Kim, D.; Cerda, I. H.; Goldiez, E.; Marino, S.; Green, A.; Fitzgerald, P.; Vijayakumar, P.; Kirca, D.; Tong, M.; Muscat, N.; Cook, M.; Knopf, K.; Tang, M.; Chen, Y.; Bueno-Junior, L. S.; Weston, R.; Liu, T.-Y.; Hartner, J.; Dinov, I.; Watson, B. O.
10.1101/2025.04.25.650637 — animal behavior and cognition — Posted on 2025-04-29
343 Endogenous CGRP activates NRF2 signaling via non-electrophilic mechanisms
Powell, K.; Wadolowski, S.; Tambo, W.; Chang, E. H.-Y.; Kim, D.; Varghese, A.; Sciubba, D.; al-Abed, Y.; Wang, P.; Li, C.
10.1101/2025.04.25.650677 — molecular biology — Posted on 2025-04-27
344 Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase
Mulholland, K. E.; Bourguet, M.; Cheng, N.; Rahman, O.; Ezerina, D.; Daly, L. A.; Lai, T.; Casanova, S. A.; Creixell, P.; Eyers, C.; Eyers, P.; Messens, J.; Byrne, D.; Sharpe, H.
10.1101/2025.04.27.650842 — molecular biology — Posted on 2025-04-27
346 Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets
Mardamshina, M.; Dorka, N.; Thielert, M.; Bjoerklund, F.; Navarro, F. B.; Casals, A. M.; Kovacs, F.; Fox, J. E. M.; Horvath, P.; Macdonald, P. E.; Mann, M.; Lundberg, E.
10.1101/2025.04.27.650857 — molecular biology — Posted on 2025-04-27
347 Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer
Seneviratne, J. A.; Crisp, C. L.; Glancy, E.; Choy, N.; Tan, W.; Neve, M.; Stammers, M.; Wang, T.; Johnstone, R.; Kaur, A.; Fennell, K. A.; Burr, M.; Parker, B.; Shakeel, S.; Eckersley-Maslin, M.
10.1101/2025.04.27.650876 — molecular biology — Posted on 2025-04-27
348 Exercise Conditioning Enhances Insulin Sensitivity with Metabolic and Glycemic Control Driven by Hepatic Silencing of HMGB1 in Type 2 Diabetic Mice
Bravo, G. M.; Paramasivam, P.; Jacquez, Q.; Sandoval, G.; Beason, H.; Ramirez, E. B.; Chi, J.; Gu, H.; Magalhaes, F. D. C.; Alvidrez, R. I. M.
10.1101/2025.04.27.650052 — molecular biology — Posted on 2025-04-27
349 PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Gonzalez-Vinceiro, L.; Espejo-Serrano, C.; Soler-Oliva, M. E.; Mateos-Martin, M. L.; Rico, D.; Gonzalez-Aguilera, C.; Gonzalez Prieto, R.
10.1101/2025.04.27.650851 — molecular biology — Posted on 2025-04-27
350 ADAR1 regulates alternative splicing through an RNA editing-independent mechanism.
Sagredo, E. A.; Karlstrom, V.; Blanco, A.; Moraga, P.; Vergara, M.; Jarvelin, A. I.; Visa, N.; Marcelain, K.; Castello, A.; Armisen, R.
10.1101/2025.03.12.642916 — molecular biology — Posted on 2025-04-28
352 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma
Saha, S.; Zhang, Y.; Gibert, M. K.; Dube, C.; Hanif, F.; Mulcahy, E.; Bednarek, S.; Marcinkiewicz, P.; Wang, X.; Kwak, G.; Hudson, K.; Sun, Y.; Dinda, M.; Saha, T.; Guessous, F.; Cruickshanks, N.; Colon, R. R.; Dell'Olio, L. G.; Anbu, R.; Kefas, B.; Kumar, P.; Klibanov, A. L.; Schiff, D.; Suk, J. S.; Hanes, J.; Mata, J.; Hafner, M.; Abounader, R.
10.1101/2025.04.01.646663 — cancer biology — Posted on 2025-04-25
353 Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response
Banuelos, C. P.; Caeiro, L. D.; Cingaram, P. R.; Beckedorff, F.; Morey, L.; Cortes, D. B.; Shiekhattar, R.; Verdun, R. E.
10.1101/2025.04.28.651040 — molecular biology — Posted on 2025-04-28
355 Mapping Architecture of Protein complexes in Arabidopsis using XL-MS
Trinh, C. S.; Shrestha, R.; Conner, W. C.; Reyes, A. V.; Karunadasa, S. S.; Liu, G.; Hu, K.; Xu, S.-L.
10.1101/2025.04.28.651104 — molecular biology — Posted on 2025-04-28
356 PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer.
Perera, R. M.; Rademaker, G.; Hernandez, G.; Dahal, S.; Miller-Phillips, L.; Li, A. L.; Luan, C.; Qiu, L.; Liegeois, M. A.; Wang, B.; Wen, K. W.; Kim, G. E.; Collisson, E. A.; Kruger, S. F.; Boeck, S.; Ormanns, S.; Guenther, M.; Heinemann, V.; Haas, M.; Yeh, J. J.; Zoncu, R.
10.1101/2025.04.22.649912 — cancer biology — Posted on 2025-04-25
358 Variation in Natural Infection Outcomes and Cancer Cell Release from Soft-Shell Clams (Mya arenaria) with Bivalve Transmissible Neoplasia
Giersch, R. M.; Sevigny, J. K.; Weinandt, S. A.; Mayo, C.; Garrett, F. E.; Tindbaek, K.; Yonemitsu, M. A.; Hart, S. F.; Metzger, M. J.
10.1101/2025.04.22.650102 — cancer biology — Posted on 2025-04-26
359 A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope
Wang, X.; Cheng, X.; Li, Z.; Ma, S.; Zhang, H.; Chen, Z.; Yao, Y.; Li, Z.; Zhong, C.; Li, Y.; Zhang, Y.; Menon, V.; Chao, L.; Li, W.; Fei, T.
10.1101/2024.12.17.628899 — molecular biology — Posted on 2025-04-29
360 CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition
Tiwari, P.; Colvin, K. J.; Kim, S. Y.; Kammula, A. V.; Chinai, J. M.; Alfaiate, N.; Revach, O.-Y.; Kistler, E.; Heo, S.; Anderson, S.; Moyer, S. M.; Sun, Z.; Cicerchia, A. M.; Palin, C. A.; Vyas, M.; Chuong, C. L.; Talamas, J. A.; Sade-Feldman, M.; Freeman, S. S.; Boland, G. M.; Yates, K. B.; Hacohen, N.; Demehri, S. W.; Doench, J. G.; Jenkins, R. W.; Hahn, W. W.; Manguso, R. T.
10.1101/2025.04.22.649109 — cancer biology — Posted on 2025-04-26
362 From Transcripts to Cells: Dissecting Sensitivity, Signal Contamination, and Specificity in Xenium Spatial Transcriptomics
Bilous, M.; Buszta, D.; Bac, J.; Kang, S.; Dong, Y. E.; Tissot, S.; Andre, S.; Alexandre-Gaveta, M.; Voize, C.; Peters, S.; Homicsko, K.; Gottardo, R.
10.1101/2025.04.23.649965 — cancer biology — Posted on 2025-04-26
363 The Role of c-Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma
Sensenbach, S.; Ngo, H. G.; Ghosh, S.; Karki, P.; Angardi, V.; Orman, M. A.
10.1101/2025.04.23.650054 — cancer biology — Posted on 2025-04-26
364 Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance
Singh, G.; Singh, S.; Mohapatra, I.; Kim, S.; Sharma, M.; Akers, J.; Nguyen, T.; Wong, E.; Moreno, M. M.; Kokkoli, E.; Vasudevan, S.; Lawler, S. E.; El-Deiry, W. S.; Gokaslan, Z.; Chen, C. C.
10.1101/2025.04.22.650094 — cancer biology — Posted on 2025-04-26
365 Unique epigenomic signatures identify biologically significant subtypes of MDS and predict response to azacitidine
Yang, Q.; Torres-Martin, M.; Taguchi, M.; Brogi, A.; Casalin, I.; Ceneri, E.; Halene, S.; DeZern, A. E.; Griffiths, E. A.; Follo, M. Y.; Finelli, C.; Radich, J. P.; Rauh, M. J.; Bejar, R.; Sekeres, M. A.; Santini, V.; Figueroa, M. E.
10.1101/2025.04.23.650336 — cancer biology — Posted on 2025-04-26
367 Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia
Han, Y.; Sarkar, H.; Xu, Z.; Darwin, S. L.-; Wei, Y.; Hang, X.; Liu, F.; Tran, K.; Wang, W.; Miller, J. M.; DeCoste, C. J.; Blohm, D. S.; Satcher, R. L.; Zhang, X. H.- F.; Kang, Y.
10.1101/2025.04.23.650120 — cancer biology — Posted on 2025-04-26
369 SNHG10 promote tumorigenesis via miR-150/VEGFA/EGFR/AKT/ERK/mTOR axis and gemcitabine resistance in PDAC
Pandya, G.; Singh, A.; Sourav, S.; Raju, S.; Kumari, R.; Sharma, R.; Goyal, V.; Das, B. C.; Sethi, G.; Pandey, A. K.; Pandita, D.; Motiani, R. K.; Garg, M.
10.1101/2025.04.24.650424 — cancer biology — Posted on 2025-04-26
372 Lysine Decarboxylation aids in UPEC intracellular survival in the early stages of urinary tract infection
Reasoner, S. A.; Wiebe, M. A.; Bermudez, T.; Brannon, J. R.; Morales, G. H.; Guice, F.; Jennings, E. Q.; Rathmell, J.; Hadjifrangiskou, M.
10.1101/2025.04.25.650641 — microbiology — Posted on 2025-04-25
375 Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells
Son, J.; Rix, L. L. R.; Fang, B.; Welsh, E. A.; Bremer, N. V.; Foglizzo, V.; Roa, P.; Sigcha-Coello, N.; Haura, E.; Drilon, A.; Koomen, J. M.; Cocco, E.; Rix, U.
10.1101/2025.04.24.650465 — cancer biology — Posted on 2025-04-26
376 Flow cytometry-based isolation combined with ultra-sensitive proteomics of Salmonella-containing phagosomes reveals novel insights into host-pathogen interactions
Chatterjee, R.; Marin-Rubio, J. L.; Cianfanelli, F. R.; Frey, A. M.; Raymond, B. B. A.; Meng, M.; Dannoura, A.; Heunis, T.; Li, M.; Filby, A.; Trost, M.
10.1101/2025.04.25.650444 — microbiology — Posted on 2025-04-25
377 Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment
Savani, M. R.; El Shami, M.; Gattie, L. C.; Smith, B. C.; Hicks, W. H.; Oken, S. S.; Zacharias, L. G.; Martin-Sandoval, M. S.; Montgomery, E. Y.; Xiao, Y.; Shi, D. D.; Rich, J. N.; Richardson, T. E.; Zinn, P. O.; Lega, B. C.; Mathews, T. P.; DeBerardinis, R. J.; McBrayer, S. K.; Abdullah, K. G.
10.1101/2023.05.29.542774 — cancer biology — Posted on 2025-04-26
378 The expanding avian influenza panzootic: skua die-off in Antarctica
Iervolino, M.; Günther, A.; Begeman, L.; Aguado, B.; Bestebroer, T. M.; Bellido-Martin, B.; Coerper, A.; Fornillo, M. V.; Fusaro, B.; Ibanez, A. E.; Leijten, L. M.; Lisovski, S.; Manez, M. B.; Reade, A.; van Run, P.; Soto, F.; Wallis, B.; Dewar, M.; Alcami, A.; Beer, M.; Vanstreels, R. E. T.; Kuiken, T.
10.1101/2025.04.25.650384 — microbiology — Posted on 2025-04-25
379 The landscape of structural variation in pediatric cancer
Greenhalgh, R.; Yang, W.; Brady, S. W.; Flasch, D. A.; Liu, Y.; Szlachta, K. A.; Tian, L.; Kolekar, P.; Wang, J.; Zhou, X.; Gerhard, D. S.; Ma, X.; Zhang, J.
10.1101/2025.04.24.650284 — cancer biology — Posted on 2025-04-26
381 Novel biomarkers in mutation-specific gene profiles highlight the involvement of COL9A3 in cancer cell plasticity in uveal melanoma
Brosens, E.; van den Bosch, Q.; Verdijk, R.; van den Bosch, T.; Owens, S.; Kennedy, S.; Fadlelseed, H.; Kilic, E.
10.1101/2025.04.24.650445 — cancer biology — Posted on 2025-04-27
383 Dual MYC and GSPT1 Protein Degrader for MYC-Driven Cancers
Nishida, Y.; Impedovo, V.; Ayoub, E.; Baran, N.; Scruggs, D. A.; Mizuno, H.; Khazaei, S.; Ostermann, L. B.; SIngh, S.; Bedoy, A.; Mak, P. Y.; Carter, B. Z.; Sugihara, E.; Takimoto, T.; Tong, Y.; Zhou, Q.; Yang, Z.; Yan, H.; Chen, D.; Maiti, A.; Sasaki, K.; Boettcher, S.; Haferlach, T.; Tiziani, S.; Ma, L.; Andreeff, M.
10.1101/2025.04.24.650490 — cancer biology — Posted on 2025-04-27
384 Globally prevalent Kelch13 mutations increase partial artemisinin resistance and fitness in Bangladeshi Plasmodium falciparum parasites
Nima, M. K.; Bhattacharyya, N.; Shoue, D.; Park, J.; Phru, C. S.; Sazed, S. A.; Kumar, S.; Alam, M. S.; Ferdig, M. T.; Mukherjee, A.
10.1101/2025.04.25.650672 — microbiology — Posted on 2025-04-25
387 ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity
Kung, C.-P.; Terzich, N. D.; Ilagan, M. X. G.; Prinsen, M. J.; Kaushal, M.; Kladney, R. D.; Weber, J. H.; Mabry, A. R.; Torres, L. S.; Bramel, E. R.; Freeman, E. C.; Sabloak, T.; Ryu, S.; Weber, W. M.; Cottrell, K. A.; Maggi, L.; Shriver, L. P.; Patti, G. J.; Weber, J. D.
10.1101/2025.01.16.633410 — cancer biology — Posted on 2025-04-27
388 Bacterial diversity turnover estimates in a continental river system
Demeter, K.; Savio, D.; Kirschner, A.; Reischer, G. H.; Kolarevic, S.; Parajka, J.; Derx, J.; Jakwerth, S.; Wurzbacher, C.; Blaschke, A. P.; Mach, R. L.; Bloeschl, G.; Farnleitner, A. H.; Eiler, A.
10.1101/2025.04.25.650558 — microbiology — Posted on 2025-04-25
390 Pfs48/45 nanobodies block Plasmodium falciparum transmission
Lyons, F.; Chmielewski, J.; Gabriela, M.; Chan, L.-J.; Tong, J.; Adair, A.; Zeglinski, K.; Gouil, Q.; Dietrich, M.; Tham, W.-H.
10.1101/2025.04.24.650534 — microbiology — Posted on 2025-04-25
391 APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE-humanized mice
Aries Marchington, M.; Gasvoda, H.; Michelotti, M.; Rodriguez-Caro, F.; Gooman, A.; Perez, A.; Hensley-McBain, T.
10.1101/2025.04.25.650741 — microbiology — Posted on 2025-04-26
392 Inclusion of JNK-independent drugs within multi-agent chemotherapy improves response in relapsed high-risk neuroblastoma
Han, J. Z.; Phimmachanh, M.; Hastings, J. F.; Leong, K. H.; Ng, B. H.; Fontaine-Titley, A.; Cadell, A. L.; O'Donnell, Y. E.; Clearwater, M.; Kamili, A.; Haber, M.; Norris, M.; Timpson, P.; Trahair, T. N.; Fletcher, J. I.; Fey, D.; Kolch, W.; Latham, S. L.; Croucher, D. R.
10.1101/2025.04.26.650760 — cancer biology — Posted on 2025-04-27
395 Fecal Microbial and Metabolic Signatures in VEO-IBD: Implications for Unique Pathophysiology
Kvitne, K. E.; Zuffa, S.; Charron-Lamoureux, V.; Mohanty, I.; Patan, A.; Mannochio-Russo, H.; Zemlin, J.; Burnett, L.; Zhang, L. S.; Cecala, M. C.; Ersoz, C.; Connelly, J. A.; Halasa, N.; Nicholson, M.; Dorrestein, P. C.; Tsunoda, S. M.; Markle, J.
10.1101/2025.04.26.650779 — microbiology — Posted on 2025-04-26
396 Multi-cellular phenotypic dynamics during the progression of breast tumors
Gsell, L.; Watson, S. S.; Sutevski, I.; Massara, M.; Soukup, K.; Eroglu, A.; Mold, J. E.; Joyce, J. A.; Hausser, J.
10.1101/2025.04.16.649085 — cancer biology — Posted on 2025-04-28
397 Antifungal biosynthesis by root-associated Streptomyces and Pseudomonas is elicited upon plant colonization
Tigani, W.; Du, C.; Elsayed, S. S.; Innocenti, P.; Carrion-Bravo, V.; Rimboi, I.; Martin, N. I.; Raaijmakers, J. M.; van Wezel, G. P.
10.1101/2025.04.26.650784 — microbiology — Posted on 2025-04-26
398 Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association
Wizel, A.; Spence, M. D. A.; Mints, M.; Britton, W.; Okolo, O.; Yu, V.; Cioffi, I.; Caruana, S.; Troob, S. H.; Faquin, W. C.; Lin, D. T.; Tirosh, I.; Puram, S. V.; Parikh, A. S.; Drier, Y.
10.1101/2025.04.21.649795 — cancer biology — Posted on 2025-04-28
400 Metabolic and Population Profiles of Active Subseafloor Autotrophs in Young Oceanic Crust at Deep-Sea Hydrothermal Vents
Elkassas, S. M.; Fortunato, C. S.; Grim, S.; Butterfield, D. A.; Holden, J. F.; Vallino, J. J.; Algar, C.; Zeigler Allen, L.; Larson, B.; Proskurowski, G.; Reddington, E.; Stewart, L.; Topcuoglu, B.; Huber, J. A.
10.1101/2025.04.25.650746 — microbiology — Posted on 2025-04-27
401 Metabolic and Population Profiles of Active Subseafloor Autotrophs in Young Oceanic Crust at Deep-Sea Hydrothermal Vents
Elkassas, S. M.; Fortunato, C. S.; Grim, S.; Butterfield, D. A.; Holden, J. F.; Vallino, J. J.; Algar, C.; Zeigler Allen, L.; Larson, B.; Proskurowski, G.; Reddington, E.; Stewart, L.; Topcuoglu, B.; Huber, J. A.
10.1101/2025.04.25.650746 — microbiology — Posted on 2025-04-27
402 Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
Zhang, Y.; Xu, M.; Yuan, J.; Hu, Z.; Jiang, J.; Sun, Y.; Huang, J.; Wang, Y.; Wang, B.; Shen, J.; Long, M.; Fan, Y.; Montone, K. T.; Tanyi, J. L.; Kim, S. H.; Tavana, O.; Vonderheide, R. H.; Chan, H. M.; Domchek, S. M.; Hu, X.; Zhang, L.
10.1101/2024.05.21.595159 — cancer biology — Posted on 2025-04-28
404 Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA
Shirani, M.; Bowie, R. S.; Tomasini, M.; Hook, R.; Ng, D.; Shebl, B.; Lyons, B.; Coffino, P.; Simon, S. M.
10.1101/2025.04.24.650501 — cancer biology — Posted on 2025-04-28
406 A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse Embryos
Spattini, C.; La Rosa, L.; Pereira, R. C.; Giantomasi, L.; Pelizzoli, R.; Tuntevski, K.; Battaglia, G.; Di Fonzo, A.; Armirotti, A.; De Pietri Tonelli, D.
10.1101/2025.04.25.650572 — cancer biology — Posted on 2025-04-28
408 Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer
Sar, F.; Chung, H. C.; Lin, Y.-Y.; Lin, D.; Morova, T.; Haegert, A.; Volik, S.; Bell, R.; LeBihan, S.; Ozturan, D.; Xue, H.; Dong, X.; Wu, R.; Kung, H.-J.; Gleave, M. E.; Lack, N. A.; Wang, Y.; Collins, C. C.
10.1101/2025.04.25.650369 — cancer biology — Posted on 2025-04-28
409 Circular 23S rRNA within archaeal ribosomes
Shi, L.-D.; Penev, P.; Nissley, A. J.; Nayak, D. D.; Sachdeva, R.; Cate, J. H. D.; Banfield, J.
10.1101/2025.04.27.650855 — microbiology — Posted on 2025-04-27
410 Adipocytes in tumour microenvironment promote chemoresistance in TNBC through oxysterols
Websdale, A.; Al-Hilali, Y.; Kim, B.; Williams, B. J.; Wastall, L.; Roberg-Larsen, H.; Hughes, T. A.; Cioccoloni, G.; Thorne, J. L.
10.1101/2025.04.24.650225 — cancer biology — Posted on 2025-04-28
411 Mechanisms of resistance to active state selective tri-complex RAS inhibitors
Sang, B.; Ye, L. F.; Hu, F.; Pourfarjam, Y.; Cuevas-Navarro, A.; Fan, S.; Fu, Z.; Washington, A.; Rodriguez, D. J.; Vides, A.; Kar, S.; Ahler, E.; Lin, K. K.; Hegde, A.; Smith, J. A.; Wolpin, B. M.; Punekar, S. R.; Spira, A. I.; Garrido-Laguna, I.; Hong, D. S.; Dar, A. C.; Yaeger, R.; Arbour, K. C.; Lito, P.
10.1101/2025.04.24.649345 — cancer biology — Posted on 2025-04-28
412 Comparative phenotypic, genomic and transcriptomic characterisation of two Salmonella Typhimurium strains for a first-in-human challenge model
Smith, C.; Bzami, A.; Zhu, X.; White, J. A.; Roa, N.; Suvarnapunya, A. E.; Smith, E.; Rydlova, A.; Varro, R.; Killidar, Z.; Luo, L.; Perez Sepulveda, B.; Gordon, M. A.; Cooke, G. S.; Choy, R. K. M.; Hinton, J. C. D.; Gibani, M. M.
10.1101/2025.04.24.650425 — microbiology — Posted on 2025-04-28
413 The Landscape of Prostate Tumour Methylation
Arbet, J.; Yamaguchi, T. N.; Shiah, Y.-J.; Hugh-White, R.; Wiggins, A.; Oh, J.; Gebo, T.; Foucal, A.; Lesurf, R.; Jung, C.-H.; Dang, R. M. A.; Agrawal, R.; Livingstone, J.; Salcedo, A.; Yao, C. Q.; Espiritu, S. M. G.; Houlahan, K. E.; Yousif, F.; Heisler, L. E.; Papenfuss, A. T.; Fraser, M.; Pope, B.; Kishan, A.; Berlin, A.; Chua, M. L.; Corcoran, N. M.; van der Kwast, T.; Hovens, C. M.; Bristow, R. G.; Boutros, P. C.
10.1101/2025.02.07.637178 — cancer biology — Posted on 2025-04-29
415 Pancreatic cancer patient-derived organoids capture therapy response and tumor evolution
Gout, J.; Perkhofer, L.; Lindenmayer, J.; Resheq, Y. J.; Schwab, J. D.; Kraus, J. M.; Roger, E.; Srinivasan, D.; Zimmer, E.; Mayer, B.; Marienfeld, R.; Gaisa, N. T.; Kühlwein, J. K.; Hänle, M.; Ettrich, T. J.; Danzer, K. M.; Beutel, A. K.; Kong, B.; Michalski, C.; Mihaljevic, A. L.; Rahbari, N. N.; Kornmann, M.; Kestler, H. A.; Seufferlein, T.; Kleger, A.
10.1101/2025.04.24.650216 — cancer biology — Posted on 2025-04-29
416 A horizontally acquired cyclic di-GMP phosphodiesterase regulated by zinc and quorum sensing
Anandhi Rangarajan, A.; Ok, K.; Malleck, M.; Ferrell, M.; O'Halloran, T.; Waters, C. M.
10.1101/2025.04.25.650742 — microbiology — Posted on 2025-04-28
417 A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer
Demetriadou, C.; Noji, M.; Good, A. L.; Mitchell-Velasquez, E.; Venkatesh, S.; Kantner, D. S.; Pennise, J.; Costa-Pinheiro, P.; Pinheiro, L. V.; Harada, T.; Nguyen, P. T. T.; Chatoff, A.; Megill, E.; Crispim, C. V. D. S.; Marcinkiewicz, M. M.; Meier, J. L.; Arany, Z.; Asangani, I.; Furth, E. E.; Stanger, B. Z.; Snyder, N. W.; Wellen, K. E.
10.1101/2025.04.23.650241 — cancer biology — Posted on 2025-04-29
418 Targeted metagenomics using probe capture detect a larger diversity of nitrogen and methane cycling genes in complex microbial communities than traditional metagenomics
Siljanen, H. M. P.; Manoharan, L.; Hilts, A. S.; Bagnoud, A.; Alves, R. J. E.; Jones, C. M.; Kerou, M.; Sousa, F. L.; Hallin, S.; Biasi, C.; Schleper, C.
10.1101/2022.11.04.515048 — microbiology — Posted on 2025-04-28
419 Oncogene SETDB1s Dual Role in Endometrial Cancer: Driving Tumor Progression and Immune Escape
Salari, K.; Hao, J.; Jilek, R.; Wells, M.; Li, T.; Johnson, E.; Meng, W.; Zibble, E.; Allen, A.; Gilbert, J.; McLerran, R.; Schuett, E.; Oliva, C.; Griguer, C. E.; Meyerholz, D. K.; Yates, M.; Keen, H. L.; Meng, X.; Xiong, Y.; Li, B.; Yang, S.
10.1101/2025.04.23.650291 — cancer biology — Posted on 2025-04-29
420 The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host
Schwarzer, S.; Bäcker, L. E.; Nijland, J. G.; Hayani Aji, I.; de Jong, A.; Moraru, C.; Steglich, C.; Quax, T. E.
10.1101/2025.04.24.650469 — microbiology — Posted on 2025-04-28
421 Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress response
Kahya, U.; Lukiyanchuk, V.; Gorodetska, I.; Weigel, M. M.; Köseer, A. S.; Alkan, B.; Savic, D.; Linge, A.; Löck, S.; Peitzsch, M.; Skvortsova, I.-I.; Krause, M.; Dubrovska, A.
10.1101/2025.04.22.650063 — cancer biology — Posted on 2025-04-29
422 The antifungal and other bioactive properties of the volatilome of Streptomyces scabiei
Stulanovic, N.; Bensaada, D.; Belde, L.; Adam, D.; Hanikenne, M.; Focant, J.-F.; Stefanuto, P.-H.; Rigali, S.
10.1101/2025.04.24.650436 — microbiology — Posted on 2025-04-28
423 Interrupting Elmsan1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells
Zhao, T.; He, L.; Wong, L. P.; Mei, S.; Xia, J.; Xu, Y.; Van Vranken, J.; Mazzola, M.; Chen, L.; Rhee, C.; Fang, T.; Fukushima, T.; Sayles, L.; Diaz, M.; Gibbons, J. A. B.; Mostoslavsky, R.; Gygi, S. P.; Dou, Z.; Sykes, D. B.; Sadreyev, R.; Sweet-Cordero, A.; Scadden, D. T.
10.1101/2025.04.25.650293 — cancer biology — Posted on 2025-04-29
426 The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models
Tarantelli, C.; Spriano, F.; Civanelli, E.; Aresu, L.; Risi, G.; Cannas, E.; Kayali, O.; Cascione, L.; Arribas, A. J.; Stathis, A.; Ko, Y. H.; Bertoni, F.
10.1101/2025.04.23.650181 — cancer biology — Posted on 2025-04-29
429 Towards robust machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles
Rotteveel, A.; Lee, W.-Y.; Kountouri, Z.; Stefanou, N.; Kivell, H.; Gluck, C.; Zhang, S.; Mershin, A.
10.1101/2024.11.19.624273 — cancer biology — Posted on 2025-04-29
433 Microbial model communities reveal widespread auxotrophies in abundant bacteria
Pacheco-Valenciana, A.; Tausch, A.; Dharamshi, J. E.; Bergland, F.; Delgado Zambrano, L. F.; Rodriguez-Gijon, A.; Andersson, A. F.; Garcia, S. L.
10.1101/2025.04.28.650956 — microbiology — Posted on 2025-04-28
439 Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating
Hollingworth, D.; Herold, K. F.; Kelly, G.; Mykhaylyk, V. B.; Zhang, D.; Wallace, B. A.; Hemmings, H. C.
10.1101/2024.11.04.621342 — biophysics — Posted on 2025-04-25
440 A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer's Disease
Zuffa, S.; Allaband, C.; Charron-Lamoureux, V.; Caraballo-Rodriguez, A. M.; Patan, A.; Mohanty, I.; Agongo, J.; Bostick, J. W.; Connerly, T.; Thron, T.; Needham, B.; de Castro Fonseca, M.; Salido, R.; Hansen, L.; Tubb, H.; Cao, J.; Kalecky, K.; Bottiglieri, T.; MahmoudianDehkordi, S.; Schimmel, L.; Kueider-Paisley, A.; Graham, S.; Siegel, D.; Wang, M.; Knight, R.; Kaddurah-Daouk, R.; Dorrestein, P. C.; Mazmanian, S.
10.1101/2025.04.28.651123 — microbiology — Posted on 2025-04-28
444 Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics
Teplenin, A. S.; Kudryashova, N. N.; Majumder, R.; de Vries, A. A. F.; Panfilov, A. V.; Pijnappels, D. A.; De Coster, T.
10.1101/2025.04.22.650000 — biophysics — Posted on 2025-04-26
445 A chromosome-scale genome assembly of the flax rust fungus reveals the two unusually large effector proteins, AvrM3 and AvrN
Sperschneider, J.; Chen, J.; Anderson, C.; Morin, E.; Zhang, X.; Lewis, D.; Henningsen, E.; Grigoriev, I. V.; Rathjen, J.; Jones, D.; Duplessis, S.; Dodds, P.
10.1101/2025.04.28.651126 — microbiology — Posted on 2025-04-28
446 Putting a lid on it: The N-terminal helix of Arf1 inhibits switching via stabilization of the overall native state
Peters, E. V. A.; Koduru, T.; Hantman, N. A.; McCallum, S. A.; Huang, Q.; Cherfils, J.; Royer, C. A.
10.1101/2025.04.22.650101 — biophysics — Posted on 2025-04-26
447 Interleukin-27 is antiviral at the maternal-fetal interface.
Merlino, M.; Barksdale, B.; Negatu, S. G.; Clements, R. L.; Miller-Ensminger, T.; Lopez, A. H.; Mani, S.; Mainigi, M.; Hunter, C.; Jurado, K.
10.1101/2025.04.28.651113 — microbiology — Posted on 2025-04-28
454 Deep Learning-Based 3D Leukocyte Differentiation Using Label-Free Higher Harmonic Generation Microscopy
Zhou, M.; Gonzalez, P. J.; Dekker, T.; Zhang, S.; Boers, L. S.; van den Heuvel, H. B.; Dijkhuis, A.; Simons, I. A.; Duitman, J. W. W.; Groot, M. L.
10.1101/2025.04.24.650417 — biophysics — Posted on 2025-04-26
455 Genome sequencing and physiological characterization of three Neoarthrinium moseri strains
Hochenegger, N. J.; Vignolle, G. A.; Schmal, M.; Mach, R. L.; Mach-Aigner, A. R.; Rahimi, M. J.; Chan, C. M.; Cai, F. M.; Druzhinina, I. S.; Zimmermann, C.
10.1101/2025.04.28.650913 — microbiology — Posted on 2025-04-28
458 Boltz-1: Democratizing Biomolecular Interaction Modeling
Wohlwend, J.; Corso, G.; Passaro, S.; Getz, N.; Reveiz, M.; Leidal, K.; Swiderski, W.; Atkinson, L.; Portnoi, T.; Chinn, I.; Silterra, J.; Jaakkola, T.; Barzilay, R.
10.1101/2024.11.19.624167 — biophysics — Posted on 2025-04-26
459 Bactericidal Membrane Attack Complex formation initiates at the new pole of E. coli
van 't Wout, M. F. L.; Hauser, F.; Holzapfel, P. I. P.; Bardoel, B. W.; de Haas, C. J. C.; Jacak, J.; Rooijakkers, S. H. M.; Heesterbeek, D. A. C.
10.1101/2025.04.25.650575 — microbiology — Posted on 2025-04-29
463 Spatial μProBe: a correlative multimodal imaging approach for spatial profiling of biological micro-environments
C. Marques, F.; Mathavan, N.; Ohs, N.; Goenczoel, C.; J. Kendall, J.; Singh, A.; Yilmaz, D.; Kuhn, G. A.; A. Schulte, F.; Wehrle, E.; Müller, R.
10.1101/2025.04.23.650252 — systems biology — Posted on 2025-04-26
464 Recognition of unique cell surface glycopolymers by diversified lectin domains specifies umbrella toxin targeting
Zhao, Q.; Vlach, J.; Park, Y.-J.; Tan, Y.; Bertolli, S. K.; Srinivas, P.; Liao, P.; Fitzpatrick, C. R.; Dangl, J. L.; Azadi, P.; DiMaio, F.; Peterson, S. B.; Zhang, D.; Veesler, D.; Mougous, J. D.
10.1101/2025.04.24.650519 — microbiology — Posted on 2025-04-29
465 Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning
Sakai, Y.; Sen, S.; Sugihara, T.; Kakeyama, Y.; Iwasaki, M.; Schertler, G.; Deupi, X.; Koyanagi, M.; Terakita, A.
10.1101/2024.12.12.628111 — biophysics — Posted on 2025-04-27
467 Plant host identity drives Andropogon gerardii rhizobiome assembly strategies under increasing abiotic stress
Vogt, B.; Kazarina, A.; Sytsma, J.; Adams, B.; Rodela, L.; Clouse, D.; Keller, R.; Thompson, D.; Winters, H.; Wagner, M.; Jumpponen, A.; Johnson, L.; Lee, S. T. M.
10.1101/2025.04.12.648431 — microbiology — Posted on 2025-04-29
470 Chemical propulsion of hemozoin crystal motion in malaria parasites
Hastings, E. M.; Skora, T.; Carney, K. R.; Fu, H. C.; Bidone, T. C.; Sigala, P. A.
10.1101/2025.04.25.650681 — biophysics — Posted on 2025-04-27
473 Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania
Foster, M. W.; McMahon, T. J.; Ngocho, J. S.; Kipengele, A. H.; Violette, M.; Chen, Y.; Madut, D. B.; Plumb, R. S.; Wong, A. I.; Chen, L.; Lee, G. M.; Sakasaka, P. A.; Mmbaga, B. T.; Crump, J. A.; McClain, M. T.; Woods, C. W.; Maro, V. P.; Rubach, M. P.
10.1101/2025.04.22.650109 — systems biology — Posted on 2025-04-26
476 Characterization of the KRas G12D-inhibitor interactions by HDX-MS and molecular dynamics simulations
Petrotchenko, E. V.; Novy, B. C.; Nagy, E.; Popov, K. I.; Cross, J. B.; Thapar, R.; Borchers, C. H.
10.1101/2025.04.22.650091 — biophysics — Posted on 2025-04-28
477 Gut bacteria degrade purines via the 2,8-dioxopurine pathway
Liu, Y.; Zhou, Z.; Bryce Jarman, J.; Chen, H.; Miranda-Velez, M.; Terkeltaub, R.; Dodd, D.
10.1101/2025.04.24.650524 — microbiology — Posted on 2025-04-29
479 A novel shared mechanism for Bacteroidota protein transport and gliding motility
Liu, X.; Avramova, M.; Deme, J. C.; Jones, R. L.; Lundgren, C. A.; Lea, S. M.; Berks, B. C.
10.1101/2025.03.12.642685 — microbiology — Posted on 2025-04-29
481 Delaying Cancer Progression by Integrating Toxicity Constraints in a Model of Adaptive Therapy
Gevertz, J. L.; Jain, H. V.; Kareva, I.; Wilkie, K. P.; Brown, J.; Huang, Y. P.; Sontag, E.; Vinogradov, V.; Davies, M.
10.1101/2025.04.24.650205 — systems biology — Posted on 2025-04-27
484 Evolution of a fuzzy ribonucleoprotein complex in viral assembly
Zhao, H.; Li, T.; Hassan, S. A.; Nguyen, A.; Datta, S. A.; Zhang, G.; Trent, C.; Czaja, A. M.; Wu, D.; Aronova, M. A.; Lai, K. K.; Piszczek, G.; Leapman, R. D.; Yewdell, J. W.; Schuck, P.
10.1101/2025.04.26.650775 — biophysics — Posted on 2025-04-28
485 Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania
Foster, M. W.; McMahon, T. J.; Ngocho, J. S.; Kipengele, A. H.; Violette, M.; Chen, Y.; Madut, D. B.; Plumb, R. S.; Wong, A. I.; Chen, L.; Lee, G. M.; Sakasaka, P. A.; Mmbaga, B. T.; Crump, J. A.; McClain, M. T.; Woods, C. W.; Maro, V. P.; Rubach, M. P.
10.1101/2025.04.22.650109 — systems biology — Posted on 2025-04-28
490 CryoDRGN-AI: Neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets
Levy, A.; Raghu, R.; Feathers, J. R.; Grzadkowski, M.; Poitevin, F.; Vallese, F.; Clarke, O. B.; Wetzstein, G.; Zhong, E. D.
10.1101/2024.05.30.596729 — biophysics — Posted on 2025-04-28
492 Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania
Foster, M. W.; McMahon, T. J.; Ngocho, J. S.; Kipengele, A. H.; Violette, M.; Chen, Y.; Madut, D. B.; Plumb, R. S.; Wong, A. I.; Chen, L.; Lee, G. M.; Sakasaka, P. A.; Mmbaga, B. T.; Crump, J. A.; McClain, M. T.; Woods, C. W.; Maro, V. P.; Rubach, M. P.
10.1101/2025.04.22.650109 — systems biology — Posted on 2025-04-29
494 Preclinical Proof of Concept for a personalized SNAPTM-TIL (Specific Neo-Antigen Peptides -TIL) therapy platform
Halder, T. G.; Kelley, E.; Soria-Bustos, J.; Thode, T.; NG, S.; Bargenquast, T.; Weston, A.; Rodriguez del Villar, R.; Kaadige, M.; Borazanci, E.; Gordon, M.; Moser, J.; Tsai, F.; Priceman, S. J.; Forman, S. J.; Xing, Y.; Altin, J.; Soldi, R.; Sharma, S.
10.1101/2024.12.12.628191 — immunology — Posted on 2025-04-25
496 Understanding the impact of blast-induced traumatic brain injury on brain cellular differentiation and mechanics at nanoscale
Masud, N.; Fonder, C.; McGovern, B.; Hasib, M. H. H.; Jackson, W. J.; Resendiz, D. C.; Rivers, C.; Bentil, S. A.; Sakaguchi, D. S.; Sarkar, A.
10.1101/2025.04.25.650643 — biophysics — Posted on 2025-04-28
497 De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias and Epilepsy
Mahling, R.; Hegyi, B.; Cullen, E. R.; Cho, T.; Rodriques, A. R.; Fossier, L.; Yehya, M.; Yang, L.; Chen, B.-X.; Katchman, A. N.; Chakouri, N.; Ji, R.; Wan, E. Y.; Kushner, J. S.; Marx, S. O.; Ovchinnikov, S.; Makinson, C. D.; Bers, D. M.; Ben-Johny, M.
10.1101/2025.04.25.649609 — biophysics — Posted on 2025-04-28
498 Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ cells response
de-Matos-Guedes, H. L.; Da-Rocha, A. A.; Dos-Santos, J. S.; Bittencourt, I. S.; De-Almeida, D. B.; Manhaes, N. C. S.; Praxedes, H.; Romano, J. V. P.; Silva-Junior, E. B.; Silva-Goncalves, A. J.; Oliveira, M. P. L.; Covre, L. P.; Oliveira-Gomes, D. C.; Da-Cruz, A. M.; da Fonseca-Martins, A. M.
10.1101/2025.04.22.650112 — immunology — Posted on 2025-04-26
499 Acquired tick resistance in Peromyscus leucopus alters Ixodes scapularis infection
Fisk, E. A.; Leonard, C. J.; Rosche, K. L.; Ramirez-Zepp, E.; Abbott, J. R.; Owen, J. P.; Shaw, D. K.
10.1101/2025.04.22.650070 — immunology — Posted on 2025-04-26
500 Complex cooperativity in DNA origami revealed via design dependent defectivity
Majikes, J.; Hasni, A.; Haridas, S.; Robertson, J.; Pintar, A.; Zwolak, M.; Liddle, J. A.
10.1101/2025.04.23.650292 — biophysics — Posted on 2025-04-29
501 GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice
Azizi, G.; Rasouli, J.; Naziri, H.; Gonzalez, M. V.; Garifallou, J.; Zhang, G.-X.; Ciric, B.; Rostami, A.
10.1101/2025.04.23.650273 — immunology — Posted on 2025-04-26
504 Mapping the free energy landscape of K-Ras4B dimerization
Koukos, P. I.; Lesgidou, N.; Dehghani-Ghahnaviyeh, S.; Velez-Vega, C.; Duca, J. S.; Cournia, Z.
10.1101/2025.04.22.650040 — biophysics — Posted on 2025-04-29
505 Large-scale HLA immunopeptidome and interactome profiling in microglia
Klaisner, S.; Hao, Y.; Beilina, A.; Park, J.-H.; Li, Z.; Iba, M.; Tindall, C.; Jin, B.; Epstein, J.; Kowal, I.; Pantazis, C. B.; Carmiol, N.; Jarreau, P.; Washecka, N.; Weller, C.; Nalls, M. A.; Keuren-Jensen, K. V.; Singleton, A. B.; Cookson, M. R.; Qi, Y. A.
10.1101/2025.04.23.650327 — immunology — Posted on 2025-04-26
507 ML-driven design of 3' UTRs for mRNA stability
Morrow, A. K.; Thornal, A.; Flynn, E. D.; Hoelzli, E.; Shan, M.; Garipler, G.; Kirchner, R.; Reddy, A. J.; Tabchouri, S.; Gupta, A.; Michel, J.-B.; Laserson, U.
10.1101/2024.10.07.616676 — synthetic biology — Posted on 2025-04-25
509 Membrane-enhanced repulsive interactions regulate protein diffusion in cell-size space
Sakuta, H.; Kanakubo, Y.; Takada, S.; Yanagisawa, N.; Oda, T.; Mayumi, K.; Sadakane, K.; Fujiwara, K.; Yanagisawa, M.
10.1101/2025.04.22.650139 — biophysics — Posted on 2025-04-29
510 Chronic Inflammation Induced Immature Neutrophils Drive Immunopathology During Subsequent Inflammatory Events
Alakesh, A.; Dorai, V. K.; Guttapadu, R.; Sagar, S. K.; Valakatte, M.; Vijaya Raghavan, J.; Mohandas, M.; S. R., K.; Chandra, N.; Jhunjhunwala, S.
10.1101/2025.04.24.650544 — immunology — Posted on 2025-04-26
512 A toolkit to characterize protein polymerization from cryo-electron tomography data
Lee, F.; Aguilar, V. M. F.; Lawrence, T.; Mancino, P.; Lin, S.; Rochon, K.; Metskas, L. A.
10.1101/2025.04.22.650024 — biophysics — Posted on 2025-04-29
513 Generation of iPSC-derived CD4+ Th1 cells enhancing chimeric antigen receptor-T cell cytotoxicity
Furukawa, Y.; Ishii, M.; Kinoshita, S.; Goto, A.; Izumi, N.; Matsuzaki, K.; Yanashima, K.; Toyota, T.; Tachibana, K.; Ando, J.; Nakauchi, H.; Ando, M.
10.1101/2025.04.24.650471 — immunology — Posted on 2025-04-26
516 Scalable TCR synthesis and screening enables antigen reactivity mapping in vitiligo
Gagliione, S. A.; Mukkamala, R. S.; Krishna, C.; Smith, B. E.; Wadsworth, M. H.; Jelinsky, S. A.; Perez, C. R.; Schmidt-Hong, L.; Katz, E. L.; Gellatly, K. J.; Ali, L. R.; Shen, J.; Holec, P. V.; Zhao, Q. H.; Chan, A. O.; Xu, E. J.; Kravarik, K. M.; Guzova, J. A.; Dobson, C. S.; Singh, H.; Garber, M.; Dougan, M.; Dougan, S. K.; Harris, J. E.; Winkler, A.; Birnbaum, M. E.
10.1101/2025.04.24.649726 — immunology — Posted on 2025-04-26
518 MARQO pipeline resolves multiparametric cellular and spatial organization in cancer tissue lesions
Buckup, M.; Figueiredo, I.; Ioannou, G.; Ozbey, S.; Cabal, R.; Tabachnikova, A.; Troncoso, L.; Le Berichel, J.; Zhao, Z.; Ward, S. C.; Hennequin, C.; Akturk, G.; Hamel, S.; Fiel, M. I.; Brody, R.; Schwartz, M.; Marron, T. U.; Kim-Schulze, S.; Gonzalez-Kozlova, E.; Roudko, V.; Hamon, P.; Merad, M.; Gnjatic, S.
10.1101/2025.04.24.650539 — immunology — Posted on 2025-04-26
520 Homeostatic neuroimmune rhythms are linked to priming of olfactory bulb responses to an intranasal inflammatory challenge
Pearson, G.; Baca, B.; Wang, J.; Gottwals, S.; Santos, N.; Burnside, A.; Denaroso, G.; Akli, S.; Karatsoreos, I.
10.1101/2025.04.24.647555 — immunology — Posted on 2025-04-26
522 Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ cells response
de Matos Guedes, H. L.; Da-Rocha, A. A.; Dos-Santos, J. S.; Bittencourt, I. S.; De-Almeida, D. B.; Manhaes, N. C. S.; Praxedes, H.; Romano, J. V. P.; Silva-Junior, E. B.; Silva-Goncalves, A. J.; Oliveira, M. P. L.; Covre, L. P.; Oliveira-Gomes, D. C.; Da-Cruz, A. M.; da Fonseca-Martins, A. M.
10.1101/2025.04.22.650112 — immunology — Posted on 2025-04-26
523 Immunometabolic Reprogramming of Monocytes in Tuberculosis Infection and Disease
Jameson, G.; Batten, I.; Dyer, A. H.; Geoghegan, C.; Murray, M.; McDonnell, N.; Murphy, D. M.; Connolly, S. A.; McLaughlin, A. M.; O Maoldomhnaigh, C.; Gleeson, L. E.; Keane, J.; Basdeo, S. A.
10.1101/2025.04.24.650431 — immunology — Posted on 2025-04-26
524 Predictive genome-wide CRISPR-mediated gene downregulation for enhanced bioproduction
Yunus, I. S.; Carruthers, D. N.; Chen, Y.; Gin, J. W.; Baidoo, E. E. K.; Petzold, C. J.; Garcia Martin, H.; Adams, P. D.; Mukhopadhyay, A.; Lee, T. S.
10.1101/2025.04.25.650723 — synthetic biology — Posted on 2025-04-29
525 Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis within Tuberculous Granulomas
Viswanathan, G.; Hughes, E. J.; Gan, M.; Xet-Mull, A. M.; Alexander, G.; Swain Lenz, D.; Liu, Q.; Tobin, D. M.
10.1101/2025.04.26.650783 — immunology — Posted on 2025-04-27
527 Antigen avidity drives the durability of the vaccine immune response.
Weidner, N. G.; Padilla, M. V.; Pruitt, L.; Cottrell, C. A.; Gonzales, K.; Kalyuzhniy, O.; Kubitz, M.; Alavi, N.; Phelps, N.; Weglarz, M.; Schief, W. R.; Abbott, R. K.
10.1101/2025.04.18.649567 — immunology — Posted on 2025-04-27
531 Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism
Li, M.; Jin, H.; Liu, Y.; Wang, Z.; Li, L.; Wang, T.; Wang, X.; Zhang, H.; Huo, B.; Yu, T.; Wang, S.; Zhao, W.; Liu, J.; Huang, P.; Cui, J.; Xia, X.
10.1101/2024.11.11.622956 — immunology — Posted on 2025-04-28
534 A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses
Nilsen, K. E.; Stenvik, J.; Skjesol, A.; Mestvedt, I. B.; Bakke, S. S.; Giambelluca, M. S.; Gravastrand, C. S.; Elamurugan, K.; Ryan, L.; Espevik, T.; Yurchenko, M.
10.1101/2025.04.25.650557 — immunology — Posted on 2025-04-28
535 A novel computational framework to identify translational potential of genetic mouse models in rare genetic obesity
Lefebvre, N.; Polosukhina, A.; Barata, A. C.; Leibovici, M.; Le Quere, P.; Paez-Pereda, M.; Saha, S.; Oury, F.
10.1101/2025.04.22.649931 — bioinformatics — Posted on 2025-04-26
536 Sialoglycans Modulate Siglec-5 - TLR4 Interactions in Osteoarthritis
Raberg, L.; Jia, F.; von Mentzer, U.; Venkatakrishnan, V.; Karlsson, N. G.; Stubelius, A.
10.1101/2025.03.18.643878 — immunology — Posted on 2025-04-28
538 makeTCR: a Flexible Platform for Rapid, Scalable, Single-Step T Cell Receptor Synthesis
Hamberger, M.; Neuhoff, M.-T.; Torres, C. M.; Tan, C. L.; Boschert, T.; Errerd, A.; Lindner, J. M.; Platten, M.; Green, E. W.
10.1101/2025.04.27.647198 — immunology — Posted on 2025-04-28
540 Immunogenicity and Structural Features of a Stabilized Clade-C HIV-1 Env Derived from a Pediatric Elite-neutralizer
Singh, S.; Kumar, S.; Chatterjee, A.; Malhotra, L.; Rahman, A.; Andrabi, I.; Mondal, B.; Katpara, S.; Sharma, S.; Bhakri, H.; Gaur, A.; Bansal, T.; Pervez, M.; Iyer, V.; Hussain, A. W.; Ahmed, S.; Kumar, R.; Ethayathulla, A. S.; Lodha, R.; Dutta, S.; Luthra, K.
10.1101/2025.04.26.649701 — immunology — Posted on 2025-04-28
544 Molecular Basis of Ionic Suppression of ZAP-70 Dependent T Cell Receptor Activation
Das, R.; Mallick, A. I.; Roy, S.; SenGupta, S.; Gangopadhyay, K.; Das, J.; Sinha, A.; Majumder, S.; Das, P. K.; Chakraborty, M. P.; Mondal, S.; Sinha, B.
10.1101/2025.04.25.650559 — immunology — Posted on 2025-04-28
551 Estimating the replicability of Brazilian biomedical science
Amaral, O. B.; Carneiro, C. F. D.; Neves, K.; Sampaio, A. P. W.; Gomes, B. V.; Abreu, M. B. d.; Tan, P. B.; Mota, G. P. S.; Goulart, R. N.; Fernandes, N. R. d. S.; Linhares, J. H.; Ibelli, A. M. G.; Sebollela, A.; Andricopulo, A. D.; Carvalho, A. A. V. d.; Silva, A. P. e.; Souza, A. S. O.; Lima, A. C. C. d.; Sousa, A. M. d.; Birbrair, A.; Borbely, A. U.; Machado, A. M.; Costa, A. d. C.; Vasconcelos, A. P. d.; Silva, A. H. B. d. L.; Souza, A. d.; Herrmann, A. P.; Bastos, A. P. A.; Nunes, A. C. C.; Castrucci, A. M. d. L.; Paula, A. B. R.; Waltrick, A. P. F.; Macedo, A. G. F. d.; Mecawi, A. S.; R
10.1101/2025.04.02.645026 — scientific communication and education — Posted on 2025-04-25
553 DYNAMIC CHANGES TO THE INTESTINAL ENVIRONMENT OCCUR THROUGHOUT RECOVERY FROM EXPERIMENTAL ISCHAEMIC STROKE
Martin, R. M. L.; Mouat, I. C.; Whelan, R.; Hegarty, L. M.; Anderson, C. J.; Dockrell, D. H.; Bain, C. C.; Ho, G.-T.; McCulloch, L.
10.1101/2025.04.25.650631 — immunology — Posted on 2025-04-28
555 Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course
The Augsburg BIO474 Consortium, ; Aburaide, S.; Ahmed, S.; Chamberlain, M.; Deleon, Y.; Elewa, A.; Hookom, A.; Juen, E.; Katasi, D.; Lee, B.; Meyer, S.; Millan, L.; Shaw, M.; Smith, D.; Vassallo, A.; Wangmo, T.; Wolfson, D.; Xiong, P.; Yaeger, L.
10.1101/2025.04.23.650323 — scientific communication and education — Posted on 2025-04-26
556 Interleukin-22 in enteroendocrine cells controls early-life gut motility through interactions with the microbiota
Rabahi, S.; Marachlian, E.; Guendel, F.; Mikdache, A.; Quintero-Castillo, K.; Maurin, L.; Di Donato, V.; Janardhana Kurup, A.; Salloum, Y.; Diabangouaya, P.; Gros, G.; Garcia Baudino, C.; Medina-Yanez, I.; Levraud, J.-P.; Lutfalla, G.; Del Bene, F.; Boekhorst, J.; Feijoo, C.; Eberl, G.; Brugman, S.; Sumbre, G.; Hernandez, P. P.
10.1101/2025.04.25.650580 — immunology — Posted on 2025-04-28
561 Microbiota Modulation Induces Elevated Duodenal Eosinophils Upon Gluten Exposure in Mice: Implications for Non-Coeliac Gluten Sensitivity
Pryor, J. C.; Hoedt, E. C.; Soh, W. S.; Fowler, S.; Caban, S.; Minahan, K.; Sherwin, S.; Nieva, C.; McCarthy, H.; Horvat, J.; Hedley, K. E.; Duncanson, K.; Talley, N. J.; Burns, G. L.; Keely, S.
10.1101/2025.04.22.649964 — immunology — Posted on 2025-04-29
564 Controlling False Discovery in CRISPR Screens
Dempster, J.; de Kegel, B.; Kalinka, A.; Vazquez, F.; Campbell, C. D.
10.1101/2025.04.24.650434 — bioinformatics — Posted on 2025-04-26
566 Harnessing systemic glycolysis-TCA cycle axis to boost the host defense against newborn infection
Wu, Z.; Tien, N. T. N.; Klabunde, B.; Aasmul-Olsen, K.; Offersen, S. M.; Yen, N. T. H.; Muk, T.; Thysen, A. H.; Brix, S.; Brustad, N.; Wang, T.; Stokholm, J.; Bonnelykke, K.; Brunse, A.; Long, N. P.; Chawes, B.; Baek, O.; Nguyen, D. N.
10.1101/2025.04.23.650144 — immunology — Posted on 2025-04-29
567 Convergence and constraint in glucosinolate evolution across the Brassicaceae
Agosto Ramos, A.; Bird, K.; Jain, A.; Okegbe, O.; Holland, L.; Kliebenstein, D. J.
10.1101/2025.04.23.650103 — plant biology — Posted on 2025-04-25
572 Enhanced semantic classification of microbiome sample origins using Large Language Models (LLMs)
Gaio, D.; Tackmann, J.; Perez-Molphe-Montoya, E.; Napflin, N.; Patsch, D.; Malfertheiner, L.; von Mering, C.
10.1101/2025.04.24.650461 — bioinformatics — Posted on 2025-04-27
574 Label-Free In-Line Characterization of Immune Cell Culture using Quantitative Phase Imaging
Serafini, C. E.; Gorti, V.; Casteleiro Costa, P.; Silva Trenkle, A. D.; Kanwar, B.; Wang, B.; Wicker, B.; Kippner, L. E.; LeCompte, I.; Chen, R. Q.; Joffe, B.; Li, Y.; Bowles-Welch, A. C.; Li, J.; Brown, C. E.; Kwong, G. A.; Balakirsky, S.; Roy, K.; Robles, F. E.
10.1101/2025.04.22.649403 — immunology — Posted on 2025-04-29
579 High-throughput prediction of peptide structural conformations with AlphaFold2
Ille, A. M.; Markosian, C.; Burley, S. K.; Whitford, P. C.; Onuchic, J. N.; Pasqualini, R.; Arap, W.
10.1101/2024.12.03.626727 — bioinformatics — Posted on 2025-04-28
580 Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines
Gonelli, C. A.; Koutsakos, M.; Esterbauer, R.; Zheng, M. Z. M.; Liu, Y.-C.; Zin, A.; Schwab, L. S. U.; Tilmanis, D.; Aban, M.; Hurt, A.; Kent, S. J.; Juno, J. A.; Wheatley, A. K.
10.1101/2025.04.28.651131 — immunology — Posted on 2025-04-29
581 Root exudation facilitate water infiltration and rewetting of dry soil
Gomez, E.; Mair, A.; Martin, I.; de las Heras Martinez, G.; Ptashnyk, M.; Dupuy, L. X.
10.1101/2025.03.26.645447 — plant biology — Posted on 2025-04-28
583 Comparison of CD4 T cell response in Plasmodium falciparum and vivax malaria
Nalubega, M.; Soon, M. S.; Andrew, D.; Dooley, N.; Loughland, J.; Engwerda, C.; Kenangalem, E.; Price, R. N.; Minigo, G.; Anstey, N. M.; Oyong, D.; Boyle, M. J.
10.1101/2025.04.28.651092 — immunology — Posted on 2025-04-29
584 Root exudation facilitates water infiltration and rewetting of dry soil
Gomez, E.; Mair, A.; Martin, I.; de las Heras Martinez, G.; Ptashnyk, M.; Dupuy, L. X.
10.1101/2025.03.26.645447 — plant biology — Posted on 2025-04-28
585 Optimal sequencing depth for measuring the concentrations of molecular barcodes
Ocari, T.; Zin, E. A.; Tekinsoy, M.; Van Meter, T.; Cammarota, C.; Dalkara, D.; Nemoto, T.; Ferrari, U.
10.1101/2024.06.02.596943 — bioinformatics — Posted on 2025-04-28
588 Breeding for durable resistance in crops: defeated loci may act as Trojan horses compromising the effectiveness of major resistance genes.
Possamai, T.; Wiedemann-Merdinoglu, S.; Lacombe, M.-C.; Dorne, M.-A.; Griem, E.; Fuchs, R.; Bogs, J.; Baltenweck, R.; Avia, K.; Merdinoglu, D.; Hugueney, P.
10.1101/2025.04.25.650562 — plant biology — Posted on 2025-04-28
591 Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection.
Cana-Quijada, P.; Morales-Martinez, P.; Rosas-Diaz, T.; Jimenez-Gongora, T.; Navarro, J. A.; Lozano-Duran, R.; Castillo, A. G.; Pallas, V.; Bejarano, E.
10.1101/2025.04.25.650579 — plant biology — Posted on 2025-04-28
592 Assessment of Reported Error Rates in Crosslinking Mass Spectrometry
Rappsilber, J.; Fischer, L.; Lenz, S.; Kolbowski, L.; bruce, j. e.; Chalkley, R. J.; Hoopmann, M. R.; Keller, A.; Moritz, R. L.; Shteynberg, D.; Trnka, M.; Viner, R.
10.1101/2025.04.27.649519 — bioinformatics — Posted on 2025-04-28
593 A global survey of intramolecular isopeptide bonds
Costa, F.; Riziotis, I.; Andreeva, A.; Kalwan, D.; de Jong, J.; Hinchliffe, P.; Parmeggiani, F.; Race, P. R.; Burston, S. G.; Bateman, A.; Barringer, R.
10.1101/2025.04.25.650565 — bioinformatics — Posted on 2025-04-28
594 Replicated repurposing of an ancestral transcriptional complex in land plants
Kongsted, T. E.; Romani, F.; Airoldi, C. A.; Haseloff, J.; Glover, B. J.
10.1101/2025.04.25.650595 — plant biology — Posted on 2025-04-28
596 Insight into the genetic network governing long-stalked glandular trichome development in Nicotiana tabacum
Berhin, A.; Ramirez, A.; Peeters, M.; Vannieuwenhuyze, M.; Legay, S.; El Amraoui, B.; Hachez, C.
10.1101/2025.04.25.650498 — plant biology — Posted on 2025-04-28
597 Systematic discovery of single-cell protein networks in cancer with Shusi
Zhang, T.; Yu, J.; Lou, S.; Liang, Z.; Liang, Y.; Li, Z.; Wang, H.; Pei, S.; Shen, N.
10.1101/2025.04.27.649905 — bioinformatics — Posted on 2025-04-28
599 Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics
Beasley, J.-M.; Dorjsuren, D.; Jain, S.; Rath, M.; Scheufen Tieghi, R.; Tropsha, A.; Simeonov, A.; Zakharov, A. V.; Muratov, E.
10.1101/2025.01.17.633658 — bioinformatics — Posted on 2025-04-28
600 SCassist: An AI Based Workflow Assistant for Single-Cell Analysis
Nagarajan, V.; Shi, G.; Arunkumar, S.; Liu, C.; Gopalakrishnan, J.; Nath, P. R.; Jang, J.; Caspi, R.
10.1101/2025.04.22.650107 — bioinformatics — Posted on 2025-04-28
601 Learning to Estimate Sample-specific Transcriptional Networks for 7000 Tumors
Ellington, C. N.; Lengerich, B. J.; Watkins, T. B.; Yang, J.; Adduri, A.; Mahbub, S.; Xiao, H.; Kellis, M.; Xing, E. P.
10.1101/2023.12.01.569658 — bioinformatics — Posted on 2025-04-28
605 Nitrogen nutrition impacts grapevine esca leaf symptom incidence, physiology and metabolism
DellAcqua, N.; Gambetta, G. A.; Comont, G.; Ferrer, N.; Rochepeau, A.; Petriacq, P.; Delmas, C. E. L.
10.1101/2024.08.31.610625 — plant biology — Posted on 2025-04-29
607 A citrullination-ubiquitination pathway controls pre-meiotic H1 eviction and is essential for gametogenesis in Arabidopsis
Li, Y.; Fei, D.; Schubert, J.; Rutowicz, K.; Kaczmarska, Z.; Linares, A.; Giraldo-Fonseca, A.; Bischof, S.; Grossniklaus, U.; Baroux, C.
10.1101/2025.04.18.649492 — plant biology — Posted on 2025-04-29
610 Tumor Microenvironment in Ovarian Cancer through Spatial Transcriptomics and Identification of Key Gene Expression Profiles
Kırboga, K. K.; Kücüksille, E. U.; Rudrapal, M.; Aktas, E.; Achar, R. R.; Deshpande, G.; Stupin, V.; Silina, E.
10.1101/2025.04.25.650590 — bioinformatics — Posted on 2025-04-28
611 Gut microbial ecosystems differ across metabolic and obesity phenotypes
Lacruz-Pleguezuelos, B.; Bazan, G. X.; Romero-Tapiador, S.; Freixer, G.; Fernandez-Cabezas, J.; Aguilar-Aguilar, E.; Martin-Segura, A.; Fernandez, L. P.; Espinosa-Salinas, I.; Ramirez de Molina, A.; Morales, A.; Tolosana, R.; Ortega-Garcia, J.; Pancaldi, V.; Marcos-Zambrano, L. J.; Carrillo de Santa Pau, E.
10.1101/2025.04.25.650405 — bioinformatics — Posted on 2025-04-28
613 Software and pipelines for registration and analyses of rodent brain image data in reference atlas space
Puchades, M. A.; Yates, S. C.; Csucs, G.; Carey, H.; Balkir, A.; Leergaard, T. B.; Bjaalie, J. G.
10.1101/2025.04.25.650563 — bioinformatics — Posted on 2025-04-28
616 Integrating population-level and cell-based signatures for drug repositioning
He, C.; Xu, Y.; Zhou, Y.; Fan, J.; Cheng, C.; Meng, R.; Wu, L.; Pan, R.; Shah, R. V.; Gamazon, E. R.; Zhou, D.
10.1101/2023.10.25.564079 — bioinformatics — Posted on 2025-04-29
618 A low protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy
Illiano, J.; Green, C. L.; Chao, A.; Lopez, L.; Schaepkens, O.; Jang, C.; Lamming, D.; Harris, D. A.
10.1101/2025.04.23.650310 — physiology — Posted on 2025-04-26
619 UniScore, a unified and universal measure for peptide identification by multiple search engines
Tabata, T.; Yoshizawa, A. C.; Ogata, K.; Chang, C.-H.; Araki, N.; Sugiyama, N.; Ishihama, Y.
10.1101/2024.10.09.617445 — bioinformatics — Posted on 2025-04-29
620 Metapipeline-DNA: A Comprehensive Germline & Somatic Genomics Nextflow Pipeline
Patel, Y.; Zhu, C.; Yamaguchi, T. N.; Wang, N. K.; Wiltsie, N.; Zeltser, N.; Gonzalez, A. E.; Winata, H. K.; Pan, Y.; Mootor, M. F. E.; Sanders, T.; Fitz-Gibbon, S. T.; Kandoth, C.; Livingstone, J.; Liu, L. Y.; Carlin, B.; Holmes, A.; Oh, J.; Sahrmann, J.; Tao, S.; Eng, S.; Hugh-White, R.; Pashminehazar, K.; Park, A.; Beshlikyan, A.; Jordan, M.; Wu, S.; Tian, M.; Arbet, J.; Neilsen, B.; Haas, R.; Bugh, Y. Z.; Kim, G.; Salmingo, J.; Zhang, W.; Anand, A.; Hwang, E.; Neiman-Golden, A.; Steinberg, P.; Zhao, W.; Anand, P.; Agrawal, R.; Tsai, B. L.; Boutros, P. C.
10.1101/2024.09.04.611267 — bioinformatics — Posted on 2025-04-29
621 Decoupling of plastid and endomembrane homeoviscous response to low temperature and darkness in Phaeodactylum tricornutum
Sérès, Y.; Serbutoviez-Verville, C.; Bonnarde, R.; Schilling, M.; Simon, M.; Salvaing, J.; Jouhet, J.; Marechal, E.; Amato, A.
10.1101/2025.04.24.650388 — physiology — Posted on 2025-04-26
623 Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude
Marti-Mateos, Y.; Midha, A. D.; Huynh, H.; Flanigan, W. R.; Blume, S. Y.; Jain, I. H.
10.1101/2025.04.24.650365 — physiology — Posted on 2025-04-26
624 PNPLA3 I148M Reduces Hepatic Triacylglycerol Secretion and Mitigates Left Ventricular Diastolic Dysfunction in MASH Diet Mice
Butcko, A. J.; Kamali, P.; Tiwari, N.; Rahman, A. A.; Teskey, G.; Adeshina, K. A.; Singh, N. K.; Granneman, J. G.; Mottillo, E. P.
10.1101/2025.04.24.650494 — physiology — Posted on 2025-04-27
627 Accumulation of Dietary and Non-Enzymatic Oxysterols in Preeclamptic Placentas: Insights into Cholesterol Dynamics in Pregnancy Complications
Zou, L.; Maldonado-Pereira, L.; Ticiani, E.; Sethuraman, V.; Olomu, N.; Long, R.; Veiga-Lopez, A.; Medina-Meza, I. G.
10.1101/2024.11.13.623499 — physiology — Posted on 2025-04-28
628 Metagenomic-scale analysis of the predicted protein structure universe
Yeo, J.; Han, Y.; Bordin, N.; Lau, A. M.; Kandathil, S. M.; Kim, H.; Karin, E. L.; Mirdita, M.; Jones, D. T.; Orengo, C.; Steinegger, M.
10.1101/2025.04.23.650224 — bioinformatics — Posted on 2025-04-29
630 Association of ulcerative colitis with atopic dermatitis: identification of shared and unique mechanisms by construction and computational analysis of disease maps
Lopata, O.; Acencio, M. L.; Wang, X.; Hemedan, A. A.; Chao, M. J.; Jelinsky, S. A.; Tran, F.; Rosenstiel, P.; Li Yim, A. Y. F.; Schneider, R.; Satagopam, V.; Ostaszewski, M.
10.1101/2025.04.23.650149 — bioinformatics — Posted on 2025-04-29
631 Humidity as a zeitgeber for circadian entrainment of insect systems
Chen, S.-C.; Goodhart, G.; Eaton, D.; Catlett, N.; Cady, T.; Tran, H.; Lutz, L. E.; Wang, L.; Girard, E.; Savino, J.; Perry, J.; Hall, L.; Bidiwala, A.; Tarter, E.; Tompkin, J.; Greene, N.; Benoit, J.
10.1101/2024.09.04.611265 — physiology — Posted on 2025-04-28
638 EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury
Calder, A. N.; Sakaguchi, T.; Peter, M.; Tobias, J.; Frankel, T.; Razumilava, N.
10.1101/2025.04.22.649788 — physiology — Posted on 2025-04-29
644 Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis
Fumado Navarro, J.; Crilly, S.; Chan, W. K.; Browne, S.; Mason, J.; Giraldo, C. V.; Pandit, A.; Lomora, M.
10.1101/2025.04.23.650161 — bioengineering — Posted on 2025-04-26
646 An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
Ramalingam, M. B.; Oh, H. J.; Sears, J. D.; Chen, C.-H.; Vala, A.; Liu, S.; Talbot, K. M.; Hossain, M. A.; Brown, P. J.; Houliston, S.; Garcia Perez, J.; Li, F.; Amare, M. G.; Halfmann, P.; Smith, J.; Hirsch, A.; Arrowsmith, C. H.; Halabelian, L.; Vargason, A. M.; Counago, R. M.; Arnold, J. J.; Cameron, C. E.; Moorman, N. J.; Heise, M. T.; Willson, T. M.
10.1101/2025.04.24.650479 — pharmacology and toxicology — Posted on 2025-04-28
647 Collagen Nanofiber Reinforced Alginate Hydrogel Tube Microbioreactors for Cell Culture
Wu, X.; Yang, Y.; Pan, Y.; Wang, Y.; Lian, X.; Dong, C.; Wang, S.; Wang, A.; Lei, Y.
10.1101/2025.04.23.650245 — bioengineering — Posted on 2025-04-26
649 Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy
Zamat, A.; Kim, C.; Sridhar, S.; Fabrega, S.; Sen, R.; Campbell, N.; Oliver, S. A.; Zha, Z.; Thiveaud, C.; Kulaksizoglu, E.; Brienen, M.; Woodworth, G.; Arvanitis, C.; Kwong, G. A.
10.1101/2025.04.23.650339 — bioengineering — Posted on 2025-04-26
650 Engineering nanoparticles that target fibroblast activation protein in cardiac fibrosis
Maduka, C. V.; Rodriguez-Rivera, G. J.; Garay-Sarmiento, M.; Perry, A. R.; Boyd, S.; Worthington, K.; Obenreder, M.; Rydahl-Kim, S.; Spinale, F. G.; Burdick, J. A.
10.1101/2025.04.23.650330 — bioengineering — Posted on 2025-04-26
651 Exploring Phage-Staphylococcus aureus Host Dynamics Through Innovative In Vitro Experiment and Pharmacokinetic/pharmacodynamic Modeling
Royet, K.; Blazere, L.; Helluin, E.; Coignet, L.; Plumet, L.; Bonhomme, M.; Kolenda, C.; Garreau, R.; Valour, F.; Medina, M.; Laurent, F.; Goutelle, S.
10.1101/2025.04.25.650594 — pharmacology and toxicology — Posted on 2025-04-29
653 Precision Breathing: Asthma Phenotyping via Machine Learning
Churcher, N. K. M.; Ganguly, A.; Ayisi-Boateng, N. K.; Adankwah, E. K.; Ansah, M. K.; Phillips, R. O.; Prasad, S.
10.1101/2025.04.24.650383 — bioengineering — Posted on 2025-04-26
655 Homology-Based Enzymatic Assembly of Modular T7 Phage Genome
Vu, J.; Chan, Z.; Murphy, N.; Shirali, A.; Han, K.; Averesch, N. J.; Kyriakakis, P.
10.1101/2025.04.24.650493 — bioengineering — Posted on 2025-04-26
656 Human Plasma-Like Medium Promotes Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Zhange, X.; Simmons, A. D.; Huggler, K. S.; Feeney, A. K.; Cantor, J. R.; Skala, M. C.; Palecek, S. P.
10.1101/2025.04.24.650456 — bioengineering — Posted on 2025-04-26
657 Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.
Balasenthilkumaran, N. V.; Bombek, L. K.; Ramirez, D.; Klemen, M. S.; Leitgeb, E. P.; Kercmar, J.; Kopecky, J.; Zhang, Y.; Sethiya, A.; Takaoglu, A.; Prabhu, D.; Fan, A.; Vitalapuram, S.; Dolensek, J.; Gosak, M.; Benninger, R. K.; Stozer, A.; Kravets, V.
10.1101/2025.04.25.650736 — bioengineering — Posted on 2025-04-27
658 Personalized CRISPR Knock-In Cytokine Gene Therapy to Remodel the Tumor Microenvironment and Enhance CAR T Cell Therapy in Solid Tumors
Launspach, M.; Macos, J.; Afzal, S.; Hohmann, J.; Beez, S.; Pilgram, M.; van der Ven, C.; Lachiheb, C.; Andersch, L.; Jens, M.; Appis, M. L.; Zirngibl, F.; Kath, J.; Stecklum, M.; Anders, K.; Wagner, D. L.; Kuehn, R.; Eggert, A.; Kuenkele, A.
10.1101/2025.04.25.650703 — bioengineering — Posted on 2025-04-27
664 Topology Determines DNA Origami Diffusion in Intestinal Mucus
Tollemeto, M.; Paffen, L. J. M. M.; Thamdrup, L. H. E.; Boisen, A.; Van Hest, J.; Patino Padial, T.
10.1101/2025.04.25.650571 — bioengineering — Posted on 2025-04-28
665 AI-driven computational pathology for recurrence risk assessment in early-stage breast cancer
Yan, C.; Li, L.; Qian, X.; Ou, Y.; Huang, Z.; Ruan, Z.; Xiang, W.; Liu, H.; Liu, J.
10.1101/2025.04.26.648504 — pathology — Posted on 2025-04-29
666 Resolving the molecular niche of pulmonary fibrosis using cryopreserved human precision cut lung slices
Sivankutty, I.; Arava, M.; Kim, J. H.; An, Z.; Matsui, E.; Sahu, D.; Cai, C.; Behrsing, H.; Gerlovin, K.; Paul, L. M.; Suki, B.; Krishnan, R.; Choudhury, S.
10.1101/2025.04.22.649643 — genomics — Posted on 2025-04-26
667 Hydrophobic Ion Pairing for Simple, Non-Toxic Transfection
Gray, M. A.; Seeler, M.; Montoya, C.; Park, J.; Mai, L. D.; Whitehead, K. A.; Champion, J. A.
10.1101/2025.04.25.650611 — bioengineering — Posted on 2025-04-28
668 Genome-wide association mapping and predictive modeling of wet bean mass in a diverse cacao collection
Bhatt, J.; Baek, I.; Lim, S.; Lee, D.; Jang, J. H.; Cohen, S. P.; Lovelace, A. H.; Kim, M. S.; Meinhardt, L. W.; Park, S.; Ahn, E.
10.1101/2025.04.23.650203 — genomics — Posted on 2025-04-26
669 Mesoscopic SCAPE Microscope with a Rescanned, Super-oblique Illumination Plane
Cao, Z.; Jiapeng, Z.; Zhang, C.; Wang, Q.; Huang, Y.; Liu, W.; Shen, B.; Chai, Y.; Zhong, Z.; Li, H.; Wen, Q.; Wang, H.; Liang, W.
10.1101/2025.04.25.650616 — bioengineering — Posted on 2025-04-28
670 Extensive modulation of a conserved cis-regulatory code across 589 grass species
Hale, C. O.; Hsu, S.-K. O.; Zhai, J.; Schulz, A. J.; AuBuchon-Elder, T.; Costa-Neto, G. M. F.; Gelfond, A.; El-Walid, M. Z.; Hufford, M.; Kellogg, E. A.; La, T.; Marand, A. P.; Seetharam, A. S.; Stitzer, M. C.; Scheben, A.; Wrightsman, T.; Romay, C.; Buckler, E. S.
10.1101/2025.04.23.650228 — genomics — Posted on 2025-04-26
672 Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites
Li, C.; Ravikrishnan, A.; Wijaya, I.; Naim, A. N. M.; Gounot, J.-S.; Wearne, S.; On, Y. Y.; Ho, E. X. P.; Ang, Q. Y.; Chia, M.; Amanda, N. H. Q.; Ramaswami, S.; Yew, Y. W.; Loh, M.; Ong, R. Y.; Ng, F.; Lee, S. H.; Chan, J.; The HELIOS Study team, ; Regina, V. R.; Dawson, T.; Chambers, J.; Common, J.; Nagarajan, N.
10.1101/2025.04.24.650393 — genomics — Posted on 2025-04-26
673 Nuclear Mitochondrial Sequences in Great Ape Telomere-to-Telomere Genomes
Torres-Gonzalez, E.; Cremona, M. A.; Storer, J. M.; Ventura, M.; O'Neill, R. J.; Makova, K. D.
10.1101/2025.04.24.650511 — genomics — Posted on 2025-04-26
678 IN4MER Bioink: A Phosphorescent Biosensing Bio-ink for Multiple Analytes (Glucose, Lactate, Oxygen) Measurements and Temperature Sensing Applications
Saleem, W.; Chimene, D.; White, B. P.; Deo, K. A.; Thomas, J. L.; Chidambara, N.; Mandrona, C.; Landsgaard, K.; Ko, B.; Kaunas, R.; Gaharwar, A. K.; McShane, M. J.
10.1101/2025.04.22.650078 — bioengineering — Posted on 2025-04-29
679 Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and rare sex
Chung, G.; Stevens, L.; Dai, X.; Hickey, S.; Kiontke, K.; Rughani, P.; Kieninger, M. R.; Collins, J. C.; Juul, S.; Piano, F.; Fitch, D. H. A.; Blaxter, M.; Gunsalus, K. C.
10.1101/2025.04.24.650375 — genomics — Posted on 2025-04-27
680 Plasmonic imaging of living pancreatic beta-cell networks
Abayzeed, S.; Galvis, D.; Medel, K. R.; Gonzalez, O. B.; Setchfield, K.; Somekh, M. G.; Wedgwood, K. C. A.; Smith, P.
10.1101/2025.04.22.649945 — bioengineering — Posted on 2025-04-29
684 Ancient DNA Reveals Hominoid Evolution: Intermediate DNA Sequences and Advances in Molecular Paleontology
Zhao, L.; Zhang, S.; Guo, Z.; Zhong, Q.; Zheng, Y.; Cai, Y.; Jia, C.; Zhang, S.; Mao, R.; Hong, C.; Wu, M.; Wang, Y.; Zheng, Z.; Zhang, Y.; Jin, Y.; Zhao, W.
10.1101/2025.04.27.650833 — paleontology — Posted on 2025-04-29
685 Chromosome-Specific Aneuploidy Engineering via dCas9-Induced Centromeric Chromatin Relaxation
FENG, H.; Deng, D.; Dahiya, R.; Wang, L.; Zeng, J.; Tan, B. J. Y.; Byrne, F.; Shepherd, S. T. C.; Wang, J.; Johnson, S. C.; Harrod, A.; Lane, K. A.; Fendler, A.; Cattin, A.-L.; Tippu, Z.; Nie, M.; Zhao, Y.; Wang, R.; Ai, W.; Bouricha, O.; Barber, T.; Dovga, Y.; Xu, Y.; Xu, Y.; Devito, L. G.; Healy, L.; Sun, Z.; Shen, W.; Wang, H.; Lim, E. S.; OToole, S. M.; Akker, S.; Drake, W. M.; Jin, H.; Downs, J. A.; McClelland, S. E.; Diffley, J. F. C.; Ly, P.; Turajlic, S.
10.1101/2025.04.25.650684 — genomics — Posted on 2025-04-27
686 In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance
Mears, K. S.; Ibrahim, K.; Allen, P. M.; Chinai, J. M.; Avila, O. I.; Muscato, A. J.; Lane-Reticker, S. K.; Rojas, A.; Knudsen, N. H.; Chao, C.-C.; Yates, K. B.; Manguso, R. T.
10.1101/2025.04.23.645810 — bioengineering — Posted on 2025-04-29
687 Genomic in vitro transcription and Nanopore direct RNA sequencing of a human B-Lymphocyte cell line
Tzadikario, T.; Akeson, S.; Esfahani, N. G.; Stein, A.; Choudhary, U.; Amar, K.; Jain, M.
10.1101/2025.04.25.650674 — genomics — Posted on 2025-04-27
690 Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas
Li, H.; Pemov, A.; Allaway, R. J.; Muir, D. F.; Chang, L.-J.; Banerjee, J.; Scott, A. J.; Nagy, J. M.; Liu, J.; Carrio, M.; Mazuelas, H.; Yachnis, A.; Lee, S. Y.; Zhang, X.; Lyu, Y.; Stewart, D. R.; Hirbe, A.; Blakeley, J. O.; Serra, E.; Wallis, D.; Wallace, M. R.
10.1101/2025.03.19.643702 — genomics — Posted on 2025-04-28
691 Septin7 is essential in early hematopoiesis, but redundant at later stages
Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.
10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-04-25
693 Extensive modulation of a conserved cis-regulatory code across 589 grass species
Hale, C. O.; Hsu, S.-K. O.; Zhai, J.; Schulz, A. J.; AuBuchon-Elder, T.; Costa-Neto, G. M. F.; Gelfond, A.; El-Walid, M. Z.; Hufford, M.; Kellogg, E. A.; La, T.; Marand, A. P.; Seetharam, A. S.; Stitzer, M. C.; Scheben, A.; Wrightsman, T.; Romay, C.; Buckler, E. S.
10.1101/2025.04.23.650228 — genomics — Posted on 2025-04-28
695 Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus
Mulvey, B.; Wang, Y.; Divecha, H. R.; Bach, S. V.; Montgomery, K. D.; Cinquemani, S.; Chandra, A.; Du, Y.; Miller, R. A.; Kleinman, J. E.; Page, S. C.; Hyde, T. M.; Martinowich, K.; Hicks, S. C.; Hansen, K. D.; Maynard, K. R.
10.1101/2024.12.07.627362 — genomics — Posted on 2025-04-28
698 Passive and active demethylation in immune diseases with proliferation driving global hypomethylation
Shimada, M.; Omae, Y.; Hitomi, Y.; Honda, Y.; Kodama, T.; Honda, M.; Tokunaga, K.; Miyagawa, T.
10.1101/2025.04.25.650620 — genomics — Posted on 2025-04-29
699 Enhanced Identifications and Quantification through Retention Time Down-Sampling in Fast-Cycling diagonal-PASEF Methods
Below, C. R.; Bernhardt, O. M.; Kaspar-Schoenefeld, S.; Willems, S.; Coronado-Barrientos, E.; Karemaker, I. D.; Streckenbach, B.; Raess, L.; Schaer, S.; Trede, D.; Krieger, J. R.; Gandhi, T.; Bruderer, R. M.; Reiter, L.
10.1101/2025.04.23.650190 — biochemistry — Posted on 2025-04-26
701 Chip (Ldb1) is a new cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation
Galouzis, C. C.; Kherdjemil, Y.; Forneris, M.; Viales, R. R.; Marco-Ferreres, R.; Furlong, E. E. M.
10.1101/2025.04.24.650404 — genomics — Posted on 2025-04-29
702 Visualisation of translating ribosomes reveals the earliest steps of protein misfolding in human disease
Plessa, E.; Chu, L. P.; Hornby, C. R.; Streit, J. O.; Mitropoulou, A. N.; Chan, S. H. S.; Irving, J. A.; Lomas, D. A.; Christodoulou, J.; Cabrita, L. D.
10.1101/2025.04.25.650147 — biochemistry — Posted on 2025-04-26
705 HaploExplore, first software specifically designed for the detection of minor allele (MiA-) Haploblocks
Manetti, M.; Hiet, S.; Rahmouni, M.; Spadoni, J.-L.; Dobiecki, A.; Lamanda, M.; Tison, M.; Labib, T.; Giuliani, C.; Le Clerc, S.; Zagury, J.-F.
10.1101/2025.04.23.650206 — genomics — Posted on 2025-04-29
708 Transposons accelerate chromosomal speciation by centromere expansion and chromosome fission
Tai, J.-H.; Wang, T.-Y.; Ma, G.-C.; Wu, Y.-W.; Yu, T.-H.; Wang, C.-F.; Liao, T.-Y.; Huang, S.-P.; Wang, F.-Y.; Terai, Y.; Wu, T.-H.; Hsu, C.-H.; Yu, H.-T.; Shao, K.-T.; Chaw, S.-M.; Wang, H.-Y.
10.1101/2025.02.13.638213 — genomics — Posted on 2025-04-29
709 Single-molecule multimodal timing of in vivo mRNA synthesis
Sethi, A. J.; Guarnacci, M.; Bilal, M.; Krishnan, K. S.; Hayashi, A.; Kanchi, M.; Nojima, T.; Preiss, T.; Eyras, E.; Hayashi, R.
10.1101/2025.04.27.650906 — genomics — Posted on 2025-04-29
710 Systematic evaluation of blood contamination in nanoparticle-based plasma proteomics
Gao, H.; Zhan, Y.; Liu, Y.; Zhu, Z.; Zheng, Y.; Qian, L.; Xue, Z.; Cheng, H.; Nie, Z.; Ge, W.; Ruan, S.; Liu, J.; Zhang, J.; Sun, Y.; Zhou, L.; Xun, D.; Wang, Y.; Xu, H.; Miao, H.; Zhu, Y. J.; Guo, T.
10.1101/2025.04.26.650757 — biochemistry — Posted on 2025-04-26
711 CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION
Agarwal, S.; Heo, L.; Chakraborty, A.; Mitra, A.; Liu, L.; Auer, N.; Swaminathan, G.; Huang, F.; Chelladurai, P.; Guardado, E.; Matos, J.; Bankar, A.; Le, C.; West, J.; Suresh, K.; Nair, R. V.; Rabinovitch, M.; Hammock, B. D.; Morisseau, C.; Wu, J. C.; Arany, Z.; Nicolls, M. R.; de Jesus Perez, V. A.
10.1101/2025.04.25.650735 — biochemistry — Posted on 2025-04-26
713 Enhanced protein precipitation with ammonia enables rapid, universal extraction of oligonucleotides for bioanalysis
Kamali, A.; Shelke, J. D.; Sanford, E. J.; Hayashi, M. M.; Chaisakhon, N.; Kolakowski, R. V.; Puri, S.; Zhang, G.
10.1101/2025.04.24.650521 — biochemistry — Posted on 2025-04-27
714 Engineering NIR-Sighted Bacteria
Meier, S. S. M.; Hörzing, M.; Böhm, C.; Düthorn, E. L. R.; Takala, H.; Uebe, R.; Moeglich, A.
10.1101/2025.04.25.650650 — biochemistry — Posted on 2025-04-27
720 cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions
Van Buren, E.; Zhang, Y.; Li, X.; Selvaraj, M. S.; Li, Z.; Zhou, H.; Palmer, N. D.; Arnett, D. K.; Blangero, J.; Boerwinkle, E.; Cade, B. E.; Carlson, J. C.; Carson, A. P.; Chen, Y.-D. I.; Curran, J.; Duggirala, R.; Fornage, M.; Franceschini, N.; Graff, M.; Gu, C.; Guo, X.; He, J.; Heard-Cosa, N.; Hou, L.; Hung, Y.-J.; Kalyani, R. R.; Kardia, S. L. R.; Kooperberg, C.; Kral, B. G.; Lange, L.; Li, C.; Liu, S.; Lloyd-Jones, D.; Loos, R. J. F.; Manichaikul, A. W.; Martin, L. W.; Mathias, R.; Minster, R.; Mitchell, B. D.; Mychaleckyj, J. C.; Naseri, T.; North, K.; O'Connell, J.; Perry, J. A.; Peyse
10.1101/2025.04.23.650307 — genetics — Posted on 2025-04-26
721 Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model
Welz, B.; Pierotti, S.; Fitzgerald, T. W.; Thumberger, T.; Suzuki, R.; Watson, P.; Fuss, J.; Cordeiro da Trindade, T.; Defranoux, F.; Ferreira, M.; Naruse, K.; Gierten, J.; Loosli, F.; Wittbrodt, J.; Birney, E.
10.1101/2025.04.24.650462 — genetics — Posted on 2025-04-26
722 TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome
von Känel, C.; Aeschlimann, S.; Husova, M.; Oeljeklaus, S.; Stettler, P.; Schnaufer, A.; Warscheid, B.; Zikova, A.; Schneider, A.
10.1101/2025.04.25.650624 — biochemistry — Posted on 2025-04-27
725 Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations
Dickson, P. E.; Datta, U.; Wilcox, T. D.; Auth, A. A.; Ball, R. L.; Dunn, M.; Fisher, H. S.; Klein, A.; Leonardo, M. R.; Roy, T. A.; Saul, M. C.; Bubier, J. A.; Gagnon, L. H.; Philip, V. M.; Tarantino, L. M.; Jentsch, J. D.; Chesler, E. J.
10.1101/2025.04.23.650259 — genetics — Posted on 2025-04-27
726 The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
Giandomenico, S. L.; Mueller, M.; van Oostrum, M.; Desch, K.; Krause, B.; Tushev, G.; Ciirdaeva, E.; Langer, J. D.; Alvarez-Castelao, B.; Schuman, E. M.
10.1101/2025.04.25.650603 — biochemistry — Posted on 2025-04-27
727 RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria
Behera, A. K.; Kim, J. J.; Kordale, S.; Damodaran, A. P.; Kumari, B.; Vidak, S.; Dickson, E.; Xiao, M.-S.; Duncan, G.; Andersson, T.; Misteli, T.; Gonatopoulos-Pournatzis, T.
10.1101/2025.04.25.648738 — genetics — Posted on 2025-04-27
728 High-throughput chemical proteomics workflow for profiling protein citrullination dynamics
Meelker Gonzalez, R.; Laposchan, S.; Riedel, E.; Fürst, A.; O'Sullivan, N.; Gabriel, W.; Wilhelm, M.; Knolle, P. A.; Medard, G.; Kuster, B.; Lee, C.-Y.
10.1101/2025.04.25.650601 — biochemistry — Posted on 2025-04-27
730 Hierarchical small molecule inhibition of MYST acetyltransferases
Chen, X.; Castroverde, A.; Perez, M.; Holewinksi, R.; Suazo, K. F.; Karki, R.; Andresson, T.; Garcia, B.; Meier, J. L.
10.1101/2025.04.25.650653 — biochemistry — Posted on 2025-04-27
731 Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium
Rozumek, G. M.; Brinkmeier, M. L.; Guan, B.; Wang, S. Q.; Tower, C.; Yang, N. T.; Lim, R.; Dong, L.; Hannum, D. F.; Moroi, S. E.; Richards, J. E.; Hufnagel, R. B.; Prasov, L.
10.1101/2025.04.21.649840 — genetics — Posted on 2025-04-28
732 Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination
Zhang, T.; Zheng, J.; Tong, Z.; Deng, Z.; He, Z.; Wu, X.; Wang, M.; Du, Y.; Xu, Z.; Tao, S.; Tian, X.; Deng, H.; Pan, M.; Ai, H.; Liu, L.
10.1101/2025.04.25.650627 — biochemistry — Posted on 2025-04-27
733 Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence.
Gall-Duncan, T.; Ko, S. Y.; Quick, I. K.; Khan, M.; Feng, K.; Kelley, C. P.; Coleman, A.; Touze, A.; Tang, S.; Mehkary, M.; Yokoi, K.; Herrington, C. R.; You, J.; Lambie, S. C.; Prasolava, T. K.; Panigrahi, G. B.; Park, J.; Nakatani, K.; Byrne, L. M.; Wang, P.; Schneekloth, J. S.; Nakamori, M.; Frankland, P. W.; Pearson, C. E.
10.1101/2025.04.25.650652 — genetics — Posted on 2025-04-28
734 Exploring the C(2)M Cohesin Complex: Structure, Dynamics, and Ability to Facilitate Assembly of the Synaptonemal Complex
Howland, M.; Nguyen, H.; Mitri, D.; Mathew, J.; Patel, N.; Gyuricza, M. R.; Jang, J. K.; McKim, K. S.
10.1101/2025.04.21.649846 — genetics — Posted on 2025-04-28
735 One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration
Stanhope, S. C.; Singhal, K.; Morato, N. M.; Feng, Y.; Meng, G.; Marlin, M. N.; Kotanko, C. C.; Jarrett, M. M.; Mesecar, A. D.; Cooks, R. G.; Weake, V. M.
10.1101/2025.04.25.650714 — biochemistry — Posted on 2025-04-27
736 Structure of active methyl-CoM reductase, Earth's main methane producer
Ohmer, C. J.; Abernathy, M. J.; Marchany-Rivera, D.; Villareal, D. G.; Simon, P. S.; Lyubimov, A.; Bhowmick, A.; Chatterjee, K.; Makita, H.; Tiwari, V.; Dasgupta, M.; Keable, S.; Mittan-Moreau, D.; Paley, D. W.; Moriarty, N. W.; Sanchez, H.; Rosenberg, D. J.; Gee, L. B.; Alonso-Mori, R.; Sauter, N. K.; Brewster, A. S.; Bergmann, U.; Yachandra, V. K.; Cohen, A. E.; Yano, J.; Kern, J.; Sarangi, R.; Ragsdale, S. W.
10.1101/2025.04.26.650772 — biochemistry — Posted on 2025-04-27
739 The temperature dependence of binding entropy is a selective pressure in protein evolution
Georgelin, R.; Bott, H.; Kaczmarski, J.; Frkic, R.; Tan, L. L.; Tokuriki, N.; Spence, M. A.; Jackson, C.
10.1101/2025.03.23.644840 — biochemistry — Posted on 2025-04-28
740 CREPE (CREate Primers and Evaluate): a computational tool for large-scale primer design and specificity analysis
Pitsch, J. W.; Wirth, S. A.; Costantino, N. T.; Mejia, J.; Doss, R. M.; Warren, A. V. A.; Yang, X.; Breuss, M. W.
10.1101/2025.03.28.646040 — genetics — Posted on 2025-04-29
744 Anks3 mediates cilia dependent polycystin signaling and is essential for adult kidney homeostasis
Wei, Z.; Rehman, M.; Gu, J.; Lerner, G.; Dong, K.; Roy, K.; Cordido, A.; Cai, Y.; Tian, X.; Tham, M. S.; Kanyo, J.; Lam, T. T.; Zhao, H.; Somlo, S.
10.1101/2025.04.22.649832 — genetics — Posted on 2025-04-29
745 Identification of uranyl-binding proteins in Arabidopsis thaliana cells exposed to uranium: Insights from a metalloproteomic analysis and characterization of Glycine-Rich RNA-binding Protein 7 (GRP7)
Revel, B. H.; Favier, A.; Martin-Laffon, J.; Vallet, A.; Przybyla-Toscano, J.; Brugiere, S.; Coute, Y.; Diemer, H.; Cianferani, S.; Rabilloud, T.; Bourguignon, J.; Brutscher, B.; Ravanel, S.; Alban, C.
10.1101/2025.04.28.650916 — biochemistry — Posted on 2025-04-28
746 SAM-AMP lyases in CRISPR defence and anti-defence
Chi, H.; McMahon, S.; Daniel-Pedersen, L.; Graham, S.; Gloster, T. M.; White, M. F.
10.1101/2025.04.28.651013 — biochemistry — Posted on 2025-04-28
747 Predicting pose distribution of protein domains connected by flexible linkers is an unsolved problem
McBride, A. C.; Yu, F.; Cheng, E. H.; Mpouli, A.; Soe, A. C.; Hammel, M.; Montelione, G. T.; Oas, T. G.; Tsutakawa, S. E.; Donald, B. R.
10.1101/2025.04.27.650885 — biochemistry — Posted on 2025-04-28
750 DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
Orr, L. M.; Tomlinson, S. J.; Grupe, H. R.; Lim, M.; Ho, E.; Yilmaz, H.; Zhou, G.; Leon, B.; Olzmann, J. A.; Nomura, D. K.
10.1101/2025.04.25.650514 — biochemistry — Posted on 2025-04-29
752 Increased rates of hybridization in swordtail fish are associated with water pollution
Moran, B. M.; Ramirez-Duarte, W. F.; Powell, D. L.; Yang, T. T.; Gunn, T. R.; Jofre-Rodriguez, G. I.; Payne, C. Y.; Iverson, E. N.; Preising, G. E.; Banerjee, S. M.; Donny, A. E.; Sood, R.; Baczenas, J. J.; Vazquez Adame, G. M.; Gutierrez-Rodriguez, C.; Rochman, C. M.; Schumer, M.; Rosenthal, G. G.
10.1101/2025.04.22.649978 — evolutionary biology — Posted on 2025-04-26
757 Gene drive dynamics in plants: the role of seedbanks
Kim, I. K.; Tian, L.; Chaffee, R.; Haller, B. C.; Champer, J.; Messer, P. W.; Kim, J.
10.1101/2025.04.24.649389 — evolutionary biology — Posted on 2025-04-26
758 Fabrication of microcompartments with controlled size and shape for encapsulating active matter
Vianay, B.; Guerin, C.; Gressin, L.; Orhant-Prioux, M.; Blanchoin, L.; Thery, M.; Colin, A.
10.1101/2025.04.23.650156 — biochemistry — Posted on 2025-04-29
760 Stereochemical Insights into Sarpagan and Akuammiline Alkaloid Biosynthesis
Mann, S. G. A.; Paz-Galeano, M.; Shahsavarani, M.; Perley, J. O.; Guo, J.; Garza-Garcia, J. J. O.; Qu, Y.
10.1101/2024.12.19.629490 — biochemistry — Posted on 2025-04-29
765 The kinase domain of RIPK3 tunes its scaffolding functions
Chiou, S.; Patel, K. M.; Preaudet, A.; Rickard, J. A.; Horne, C. R.; Young, S. N.; Garnish, S. E.; Hempel, A.; Hall, C.; Hildebrand, J.; Kueh, A. J.; Putoczki, T. L.; Hawkins, E. D.; Samson, A. L.; Murphy, J. M.
10.1101/2025.04.29.651198 — biochemistry — Posted on 2025-04-29
767 Genealogical analysis of replicate flower colour hybrid zones in Antirrhinum
Pal, A.; Shipilina, D.; Moan, A. L.; McNairn, A. J.; Grenier, J. K.; Kucka, M.; Coop, G.; Chan, Y. F.; Barton, N. H.; Field, D.; Stankowski, S.
10.1101/2025.04.27.649910 — evolutionary biology — Posted on 2025-04-28
771 Speed Matters: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli
Ali, K. M.; Murphy, R.; Zanchi, C.; Zunk-Parras, S. A.; Rodriguez-Rojas, A.; Rolff, J.
10.1101/2025.04.25.650648 — evolutionary biology — Posted on 2025-04-29
774 Proteomic characterisation of Japanese quails unique seminal foam
Mason, C.; Garlovsky, M.; Vedder, O.; Pham, T. K.; George, R.; Tschirren, B.; Hemmings, N.
10.1101/2025.04.23.650219 — evolutionary biology — Posted on 2025-04-29
783 Tissue heterogeneity is associated with phenotypic but not genomic diversity in Wolbachia endosymbionts
Pigeault, R.; Dussert, Y.; Jorge, R.; Ulve, T.; Panza, M.; Raimond, M.; Delaunay, C.; Aucher, W.; Berges, T.; Ogereau, D.; Moumen, B.; Peccoud, J.; Cordaux, R.
10.1101/2024.06.20.599863 — evolutionary biology — Posted on 2025-04-29
789 To Peck or Not To Peck: The influence of early-life social environment on response inhibition and impulsive aggression in Japanese quails
Vernouillet, A.; Willcox, K.; Allaert, R.; Dewulf, A.; Zhang, W.; Troisi, C. A.; Knoch, S.; Martel, A.; Lens, L.; Verbruggen, F.
10.1101/2024.12.20.629368 — animal behavior and cognition — Posted on 2025-04-29
790 Detecting infection-related mortality using dynamical statistical indicators of high-resolution activity time series
Kutzer, M. A. M.; Abdullateef, S.; Cano, A. V.; Soare-Nguyen, I. L.; Montieth, K. M.; Escudero, J.; Dakos, V.; Vale, P. F.
10.1101/2025.04.21.649753 — ecology — Posted on 2025-04-25
792 Host genetics and the Skin Microbiome Independently Predict Parasite Resistance
Kramp, R. D.; Janecka, M.; Tardent, N.; Jokela, J.; Kohl, K. D.; Stephenson, J. F.
10.1101/2024.10.19.619196 — ecology — Posted on 2025-04-25
793 Big Data, Sound Science, Lasting Impact: a framework for passive acoustic monitoring
Wall, C. C.; McKenna, M.; Hatch, L. T.; Van Parijs, S. M.; Bochenek, R.; Dugan, P.; Parcerisas, C.; Ryan, J.; Anderson, C. D.; Becker, K.; Berchok, C.; Biddle, M.; Boebel, O.; Canino, A.; Canonico, G.; Cline, D.; Davis, G. E.; Frasier, K.; Gedamke, J.; Haver, S. M.; Khazmutdinova, K.; Kinneging, N.; Kumar, A.; Marian, A.; Miksis-Olds, J.; Montie, E. W.; Ponirakis, D.; Rice, A. N.; Rowell, T. J.; Rueda, C.; Shumchenia, E.; Shyka, T.; Staaterman, E.; Thomisch, K.
10.1101/2025.04.22.650104 — ecology — Posted on 2025-04-26
796 Environmental heterogeneity plays a bigger role than diet quality in driving divergent California sea lion population trends
Pozas Franco, A. L.; ROSEN, D. A. S.; Trites, A. W.; Hernandez-Camacho, C. J.; Garcia-Rodriguez, F. J.
10.1101/2025.04.23.650199 — ecology — Posted on 2025-04-26
801 Quantifying the net effect of biodiversity on stability
Kunze, C.; Bahlburg, D.; Striebel, M.; Schott, T.; Donohue, I.; Hillebrand, H.
10.1101/2025.04.24.650410 — ecology — Posted on 2025-04-26
802 Hidden Diversity of Threatened Sharks and Rays in the Global Meat Trade
MacNeil, M. A.; Mull, C.; Martins, A.; Babcock, E.; Tyabji, Z.; Andorra, A.; Clarke, S.; Jabado, R.; Sant, G.; Cinner, J.; Gephart, J.; Dulvy, N.; Oakley-Cogan, A.; Kasana, D.; Warwick, L.; Simpfendorfer, C.; Fowler, S.; de Araujo Freire, M.; Bariche, M.; Beaufort, O.; Bizzarro, J.; del Pilar Blanco, M.; Braccini, M.; Barullio de Luna Sales, J.; Bustamante, C.; Carlson, J.; Charvet, P.; Cuevas, J.; Fernandes, C.; Fernando, D.; Finucci, B.; Garcia Rodriguez, E.; Gonzalez-Pestana, A.; Cardoso, L.; Hauser-Davis, R.; Muttaqin, E.; Polo-Silva, C.; Ready, J.; Ruiz-Garcia, D.; Saldana Ruiz, L.; Seidu
10.1101/2025.04.24.650194 — ecology — Posted on 2025-04-26
807 Genome scale metabolic modelling of human gut microbes to inform rational community design
Ortiz, J. P. M.; McClure, D. D.; Holmes, A.; Rice, S. A.; Read, M. N.; Shanahan, E. R.
10.1101/2024.05.28.596116 — ecology — Posted on 2025-04-28
808 On the quest for novelty in ecology
Ottaviani, G.; Martinez, A.; Petit Bon, M.; Mammola, S.
10.1101/2023.02.27.530333 — ecology — Posted on 2025-04-28
810 Trait-environment interactions influence tree planting success in Peruvian tropical dry forests
Goossens, W.; Fremout, T.; Muys, B.; Soto Quispe, J. C.; Van Meerbeek, K.; Maes, S. L.
10.1101/2025.02.21.639418 — ecology — Posted on 2025-04-28
815 Highly Dynamic Population of Owned Dogs and Implications for Zoonosis Control
Diaz, E. W.; Sila, S.; Raynor, B. B.; De la Puente-Leon, M.; Levy, M. Z.; Castillo-Neyra, R.
10.1101/2025.04.23.650047 — ecology — Posted on 2025-04-28
817 Forest biogeochemical monitoring indicates altered microbial communities, macronutrient availability, CO2 emissions and litter chemistry in root zone soil of oak trees with Acute Decline symptoms
Dhandapani, S.; McNeil, T.; Lu, B.; Booth, O.; Corbett, L.; Lunn, J.; Nightingale, A.; Niu, X.; Roose, T.; John, J.; Lin, H.; Adekanmbi, A. A.; Shaw, L. J.
10.1101/2025.04.22.650028 — ecology — Posted on 2025-04-29
818 On the edge of extinction: Delayed plant genetic response to forest edge dynamics
Hostens, L.; Metsu, C.; Van Acker, K.; Peeters, G.; de Beer, S.; Gansemans, Y.; Kupcinskiene, E.; Jociene, L.; Krokaite-Kudakiene, E.; Paulssen, J.; Mazalla, L.; Diekmann, M.; Conradi, T.; Plössner, S.; Deak, B.; Valko, O.; Fekete, R.; Orczewska, A.; Hedwall, P.-O.; Brunet, J.; Huang, S.; Feigs, J. T.; Naaf, T.; Wulf, M.; Plue, J.; Liira, J.; Deforce, D.; Van Nieuwerburgh, F.; De Frenne, P.; Vandelook, F.; Van Meerbeek, K.; Honnay, O.; De Kort, H.
10.1101/2025.04.23.649530 — ecology — Posted on 2025-04-29
820 Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression
Perfetto, M.; Danoff, A.; Ishfaq, M.; Monroe, H.; Mohideen, A.; Chen, M.; Stratman, A. N.; Okawa, S.; Yien, Y. Y.
10.1101/2022.08.22.504833 — developmental biology — Posted on 2025-04-25
821 NSD2 links developmental plasticity to mitochondrial function in muscle and lymphocyte differentiation
Martinez-Cano, J.; Sagrera, A.; Estrada, B. S.; Cogliati, S.; Martinez-Martin, N.; Cobaleda, C.
10.1101/2025.04.26.648922 — developmental biology — Posted on 2025-04-26
823 Embryonic Durotaxis: A Mechanical Framework for Understanding Cesarean Scar Pregnancy
Cao, J.; You, H.; Li, J.; Yue, S.; Song, B.; Li, H.; Wei, J.; Guan, D.; Zu, Y.; Zheng, X.; Wang, Y.; Fan, Y.; Du, J.
10.1101/2025.04.24.650347 — developmental biology — Posted on 2025-04-26
826 Inhibiting SOX18 with propranolol restores vascular integrity in NR2F2-driven malformations
Graus, M. S.; Jha, S. K.; Lou, J.; Holm, A.; Wong, Y. Y.; Davidson, T.; Coleman, P.; Sugo, E.; Luu, W.; Karnezis, T.; Gamble, J.; McCaughan, G.; Nightingale, S.; Bischoff, J.; Maruyama, K.; Hinde, E.; Red-Horse, K.; Francois, M.
10.1101/2025.04.25.650344 — developmental biology — Posted on 2025-04-27
830 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.
Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devarakonda, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J. W.; Skeath, J. B.; Lacin, H.
10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-04-28
831 Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses.
Wilson, P.; Vishwakarma, V.; Norcross, R.; Khaire, K. S.; Pham, V. N.; Jung, H. M.; Weinstein, B. M.; Galperin, E.
10.1101/2025.03.26.645567 — developmental biology — Posted on 2025-04-28
832 TCA cycle rewiring underpins implantation and histone acetylation programming
Kafkia, E.; Pladevall-Morera, D.; Argemi-Muntadas, L.; Wang, G.; Noberini, R.; Bages-Arnal, S.; Anagho-Mattanovich, M.; Silverio-Alves, R.; Bonaldi, T.; Rabelink, T. J. J.; Moritz, T.; Zylicz, J. J.
10.1101/2025.04.25.650409 — developmental biology — Posted on 2025-04-28
838 JNK MAPK Regulates IFN-Stimulated Genes and Cell Adhesion in Chemoresistant, Quiescent Leukemic Cells
Lee, S.; Baradar, A. A.; Buitrago, P. A. S.; Puente, E.; Kilinc, Z.; Cox, O.; Vasudevan, S.
10.1101/689570 — cell biology — Posted on 2025-04-25
840 Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes
Valencia, D. A.; Koeberlein, A. N.; Nakano, H.; Rudas, A.; Patel, A. A.; Harui, A.; Spencer, C.; Nakano, A.; Quinlan, M. E.
10.1101/2024.10.13.618125 — cell biology — Posted on 2025-04-27
841 The biophysical mechanism of mitochondrial pearling
Sturm, G.; Hake, K.; Lefebvre, A. E. Y. T.; Rux, C. J.; Ivanova, D.; Millett-Sikking, A.; Tharp, K. M.; Rao, B.; Closser, M.; Waite, A. J.; Precido-Lopez, M.; Ritter, A. T.; Dumont, S.; Lu, W.; Manley, S.; Landoni, J. C.; Marshall, W. F.
10.1101/2024.12.21.629509 — cell biology — Posted on 2025-04-27
842 Diabetes-associated MYT1 and MYT3 regulate human beta-cell insulin secretion and survival via other diabetes-risk genes
Hu, R.; Yagan, M.; Wang, Y.; Tong, X.; Hamilton, N.; Doss, T.; Liu, J.-H.; Xu, Y.; Simmons, A.; Lau, K.; stein, r.; Kaverina, I.; Coate, K. C.; Liu, Q.; Gu, G.
10.1101/2025.02.24.639737 — cell biology — Posted on 2025-04-27
844 Mitochondrial Dysfunction Induces Hepatic Lipid Accumulation and Inflammatory Responses in mtDNA Mutator Mice
Ross, J. M.; Kim, A.; Berthod, K.; Mamede-Branca, R.; Olin, M.; Pichardo-Casas, I.; Lehtio, J.; Bjorkhem, I.; Sinclair, D. A.; Olson, L.; Coppotelli, G.
10.1101/2025.04.25.650453 — cell biology — Posted on 2025-04-28
845 Mono-Ubiquitylation-Dependent Rap2 Activation Regulates Lamellipodia Dynamics During Cell Migration
Neumann, A. N. J.; Sampath, r.; Mayerhofer, E.; Mikalayeva, V.; Skeberdis, V. A.; Sarapiniene, I.; Prekeris, R.
10.1101/2025.04.25.650668 — cell biology — Posted on 2025-04-28
846 Outer Kinetochore Proteins form Linear Elements to Regulate Vesicle Transport
Kowaleski, S. J.; Bridgewater, A.; Saraceno, C.; Dudek, M.; Pelisch, F.; Bembenek, J.
10.1101/2025.04.25.650656 — cell biology — Posted on 2025-04-28
848 The V-ATPase/ATG16L1 axis drives membrane remodeling during epithelial morphogenesis
Baonza, G.; Alfonso, T.; Herranz, G.; Quintana-Quintana, C.; Gordillo-Vazquez, C.; El Mazjoub, Y.; Escudero, L. M.; Miguez, D. G.; Marti, E.; Martinez-Martin, N.; Martin-Belmonte, F.
10.1101/2025.04.28.650675 — cell biology — Posted on 2025-04-28
849 Deep Learning-coupled Proximity Proteomics to Deconvolve Kinase Signaling In Vivo
Jha, K.; Shonai, D.; Parekh, A.; Uezu, A.; Fugiyama, T.; Yamamoto, H.; Parameswaran, P.; Yanagisawa, M.; Singh, R.; Soderling, S. H.
10.1101/2025.04.27.650849 — cell biology — Posted on 2025-04-28
850 Mitotic phosphorylation of Lamin B1 rod domain by ULK1 and Aurora A/PLK1 promotes spindle function.
Mendiburo, M. J.; Kalus, C.; Berleth, N.; Berning, L.; Sun, Y.; Hu, Z.; Shahba, A.; Naren, P.; Kasof, G.; Dengjel, J.; Stork, B.
10.1101/2025.04.25.650690 — cell biology — Posted on 2025-04-28
851 SSNA1 organizes the distal luminal centriolar network and promotes ciliogenesis without microtubule association
Huang, Y.-C.; Chong, X.-J.; Chang, T.-J. B.; van Grinsven, E.; Chen, W.-J.; Hsu, W.-B.; Beekman, J. M.; Tang, T. K.; Akhmanova, A.; Yang, T. T.; Wei, J.-H.
10.1101/2025.04.28.648957 — cell biology — Posted on 2025-04-28
853 Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair
Zhang, L. J.; Elsallabi, O.; Soto-Palma, C.; Bartz, J.; Salekeen, R.; Nunes, A.; Xu, W.; Lee, K.; Hughes, B.; Zhang, B.; Mohamed, A.; Mcgowan, S.; Angelini, L.; O'Kelly, R.; Biashad, S. A.; Hillpot, E.; Morandini, F.; Seluanov, A.; Gorbunova, V.; Dong, X.; Niedernhofer, L. J.; Robbins, P. D.
10.1101/2025.04.27.650852 — cell biology — Posted on 2025-04-28
854 Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
Nadler, A.; Barahtjan, P.; Cook, K. C.; Bocan, V.; Lennartz, H. M.; Jumel, T.; Schuhmann, K.; Traikov, S.; Bölig, K.; Kuhn, S. M.; Jimenez-Lopez, C.; Alves, T. C.; Shevchenko, A.; Rodenfels, J.
10.1101/2025.04.27.650841 — cell biology — Posted on 2025-04-28
855 The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung
Siller, S. S.; Yang, T.; Nouws, J.; Kim, S.-J.; Kim, S.-H.; Santofimia-Castano, P.; Iovanna, J.; McDonough, J. E.; Sauler, M.
10.1101/2025.04.27.650854 — cell biology — Posted on 2025-04-28
857 The Infraslow Fluctuation of Sigma Power During Sleep in Young Individuals with Schizophrenia
Dimitriades, M. E.; Schumacher, E.; Arudchelvam, J.; Fattinger, S.; Kurth, S.; Pugin, F.; Wehrle, F.; Jaramillo, V.; Volk, C.; Leach, S.; Buckley, A.; Driver, D.; Markovic, A.; Rapoport, J. L.; Tarokh, L.; Huber, R.; Gerstenberg, M.
10.1101/2025.04.23.650209 — neuroscience — Posted on 2025-04-26
858 Neuronal processes contain the essential components for the late steps of ribosome biogenesis
Fusco, C. M.; Staab, A.; Bourke, A. M.; Tushev, G.; Desch, K.; Moreto Lins, E.; Ciirdaeva, E.; tom Dieck, S.; Kaltenschnee, N.; Heckel, A.; Langer, J. D.; Schuman, E. M.
10.1101/2025.04.28.650935 — cell biology — Posted on 2025-04-28
859 Shape-Shifting Conotoxins Reveal Divergent Pore-Targeting Mechanisms in Nicotinic Receptors
Bhattacharjee, B.; Noviello, C. M.; Rahman, M. M.; Mayer, J. P.; Gajewiak, J.; McIntosh, J. M.; Hibbs, R. E.; Stowell, m. H. B.
10.1101/2025.04.23.650119 — neuroscience — Posted on 2025-04-26
860 Increased in vivo transduction of AAV-9 cargo in Alport podocytes
Williams, E.; Fresquet, M.; Bolas, G.; Kaseda, S.; Goncalves, K.; Steinsapir, A.; Adamson, A. D.; Sherwood, D. R.; Lennon, R.
10.1101/2025.04.28.650965 — cell biology — Posted on 2025-04-28
861 Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM
Matsushima, K.; Sumikama, T.; Suzuki, T.; Ito, M.; Nagasawa, Y.; Sumino, A.; Flechsig, H.; Ogoshi, T.; Umeda, K.; Kodera, N.; Murakoshi, H.; Shibata, M.
10.1101/2025.04.24.650392 — neuroscience — Posted on 2025-04-26
862 NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice
Egbase, D.; Sayers, S.; Haq, N.; Varghese, J.; Gesheva, V.; Bhattacharya, S.; Kynaston, J.; Hubber, E.; Smith, L.; Pullen, T.; Gerdes, H.; Lee, V.; Hopkins, D.; Zhao, M.; Cheah, Y.; Greally, J.; Butterworth, S.; Pearson, J. A.; Bewick, G. A.; Persaud, S.; Caton, P.
10.1101/2025.01.14.632985 — cell biology — Posted on 2025-04-28
863 Neural microexons modulate arousal states via cAMP signalling in zebrafish
Mackensen, T.; Iniguez, L. P.; Mullen, T. S.; Rodriguez-Marin, C.; Kroll, F.; Zuccarini, G.; Fernandez-Albert, J.; Sancho-Vila, L.; Permanyer, J.; Bianco, I. H.; Orger, M. B.; Rihel, J.; Irimia, M.
10.1101/2025.04.24.650407 — neuroscience — Posted on 2025-04-26
864 Maturation stage-specific V-ATPase disassembly can explain neutral pH of lysosome-related organelles
Pradhan, A.; Tadasare, N.; Sarkar, D.; Maurya, V.; Bansal, L. K.; Turkewitz, A. P.; Kumar, S.
10.1101/2025.01.13.632790 — cell biology — Posted on 2025-04-28
866 SON-dependent nuclear speckle rejuvenation alleviates proteinopathies
Dion, W.; Tao, Y.; Chambers, M.; Zhao, S.; Arbuckle, R. K.; Sun, M.; Kubra, S.; Schaich, M.; Nie, Y.; Ye, M.; Jamal, I.; Larsen, M. B.; Camarco, D.; Ickes, E.; Wang, H.; DuPont, C.; Wang, B.; Liu, S.; Pi, S.; Van Houten, B.; Chen, B. B.; Chen, Y.; Chen, X.; Zhu, B.
10.1101/2024.04.18.590103 — cell biology — Posted on 2025-04-28
867 Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life development
Lemmik, H.; Kim, E.; MacNicol, E.; Maselli, D.; Bernanos, M.; Li, Z.; Abdullahi, D.; Walters, E.; Serrano Navacerrada, M. E.; Zhou, W.; Ivetic, A.; Cash, D.; Westacott, L.
10.1101/2025.04.24.650541 — neuroscience — Posted on 2025-04-26
868 The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles
Sutcu, H. H.; Thomas-Joyeux, A.; Cardot-Martin, M.; Dugue, D.; Vianna, F.; Perrot, Y.; Benadjaoud, M. A.; Benderitter, M.; Baldeyron, C.
10.1101/2024.06.24.600399 — cell biology — Posted on 2025-04-28
869 Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
Barahtjan, P.; Cook, K. C.; Bocan, V.; Lennartz, H. M.; Jumel, T.; Schuhmann, K.; Traikov, S.; Bölig, K.; Kuhn, S. M.; Jimenez-Lopez, C.; Alves, T. C.; Shevchenko, A.; Rodenfels, J.; Nadler, A.
10.1101/2025.04.27.650841 — cell biology — Posted on 2025-04-28
871 Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation
York, N. S.; Rivera, J. E.; Manesh, M. R.; Lynes-Ford, K. W.; Smith, R.; Wicki-Stordeur, L. E.; Arbour, L. T.; Swayne, L. A.
10.1101/2024.12.10.627787 — cell biology — Posted on 2025-04-29
882 Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management
Moura-Assis, A.; Plucinska, K.; Baleisyte, A.; David, D.; Pellegrino, K.; Parolari, L.; Shaked, P. T.; Page, K. J.; Douglas, D. W.; Carrol, T. S.; Grajales-Reyes, J. G.; Na, D.; Schiffer, H. H.; Chen, Y.; Sun, H.; Cohen, N.; Monenschein, H.; Barker, D. F.; Ortuno, M. J.; Renier, N.; Cohen, P.; Carlton, M.; Heintz, N.; Brice, N. L.; Friedman, J. M.; Schneeberger, M.
10.1101/2025.04.24.650283 — neuroscience — Posted on 2025-04-27
884 Modelling Fragile X-Associated Neuropsychiatric Disorders in Young Inducible 90CGG Premutation Mice
Caliskan, G.; Lacalle, S. E.; Kul, E.; Angel, M. d.; Zambrano, A. L.; Hukema, R.; Santos, M.; Stork, O.
10.1101/2025.04.24.650447 — neuroscience — Posted on 2025-04-27
885 Inferring macroscopic intrinsic neural timescales using optimal control theory
Kim, J. Z.; Betzel, R. F.; Beyh, A.; Howell, A.; Kuceyeski, A.; Larsen, B.; Seguin, C.; Zhang, X.-H.; Holmes, A.; Parkes, L.
10.1101/2025.04.24.650287 — neuroscience — Posted on 2025-04-27
889 Combined CSF1R Inhibition and Sensory Gamma Stimulation Provide Protective Effects in a Mouse Model of Alzheimers Disease
Adaikkan, C.; Islam, M. R.; Bozzelli, P. L.; Sears, M.; Parro, C.; Pao, P.-C.; Sun, N.; Kim, T.; Abdelaal, K.; Sedgwick, M.; Kellis, M.; Tsai, L.-H.
10.1101/2025.04.27.648471 — neuroscience — Posted on 2025-04-28
890 Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals
Stewart, C.; Liddle, A.; Tolla, E.; Lewis, J. E.; Marshall, C. J.; Evans, N.; Morgan, P.; Ebling, F.; Stevenson, T.
10.1101/2025.04.22.650143 — neuroscience — Posted on 2025-04-28
893 No Disconnection Syndrome after Near-Complete Callosotomy
Bekir, S.; Hopf, J. L.; Paul, T.; Wiemer, V. M.; Santander, T.; Skinner, H. E.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.
10.1101/2025.02.16.638524 — neuroscience — Posted on 2025-04-28
897 Circuit-specific selective vulnerability in the DMN persists in the face of widespread amyloid burden.
Brunwasser, S. J.; McGregor, J. N.; Farris, C.; Elmore, H.; Dyer, E. L.; Nair, K. B.; Whitesell, J. D.; Harris, J. A.; Hengen, K. B.
10.1101/2022.11.14.516510 — neuroscience — Posted on 2025-04-28
899 Toward Unified Biomarkers for Focal Epilepsy
Wang, S. H.; Ferrari, P.; Arnulfo, G.; Marzulli, M.; Degras, D.; Myrov, V.; Palva, S.; Nobili, L.; Ciuciu, P.; Palva, M.
10.1101/2025.04.15.647522 — neuroscience — Posted on 2025-04-28
901 Neuroinflammation driven by TLR7 activation in mice results in a global inflammatory response driving circuit-specific changes in neuronal gene expression
Gardner-Steven, K.; Carvajal-Quisilema, R.; Andrianova, L.; McGonigal, R.; Sharma, D.; Barrie, J.; Saathoff, M.; Cole, J. J.; Jamieson, N. B.; Craig, M. T.; Cavanagh, J. T.
10.1101/2025.04.25.650583 — neuroscience — Posted on 2025-04-28
902 An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster
Zung, J. L.; Namiki, S.; Meissner, G. W.; Cheong, H. S. J.; Costa, M.; Eichler, K.; Stürner, T.; Jefferis, G. S. X. E.; Managan, C.; FlyLight Project Team, ; Korff, W.; Card, G. M.
10.1101/2025.02.22.639679 — neuroscience — Posted on 2025-04-28
905 Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex
Kamm, G. B.; Boffi, J. C.; Abd El Hay, M.; Rajot, D.; Cukic, A.; Havenith, M.; Scholvinck, M.; Renier, N.; Asari, H.; Prevedel, R.
10.1101/2025.04.28.651028 — neuroscience — Posted on 2025-04-28
907 Preclinical assay of the effects of lacosamide, pregabalin and tapentadol on the rat N1 spinal somatosensory evoked potential.
Steel, K. A. J.; Dunham, J. P.; Leone, C.; Truini, A.; Treede, R.-D.; Phillips, K. G.; Krajewski, J.; Blockeel, A.; Pickering, A. E.
10.1101/2025.04.25.650582 — neuroscience — Posted on 2025-04-28
910 Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP
Ramos-Torres, K. M.; Takahashi, K.; Radomski, K. L.; Mandeville, E. T.; Zhang, L.; Zhou, Y.-P.; Lo, E. H.; Armstrong, R. C.; Brugarolas, P.
10.1101/2025.04.23.650093 — neuroscience — Posted on 2025-04-28
911 Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP
Ramos-Torres, K. M.; Takahashi, K.; Radomski, K. L.; Mandeville, E. T.; Zhang, L.; Zhou, Y.-P.; Lo, E. H.; Armstrong, R. C.; Brugarolas, P.
10.1101/2025.04.23.650093 — neuroscience — Posted on 2025-04-28
916 Optimizing electrode placement and information capacity for local field potentials in cortex
Willis, J. A.; Wright, C. E.; Zhu, R.; Ruan, Y.; Stallings, J.; Abrego, A. M.; Joshi, A. A.; Leahy, R. M.; Tandon, N.; Seymour, J. P.
10.1101/2025.04.25.650658 — neuroscience — Posted on 2025-04-28
917 Vasoactive Neuropeptide Dysregulation: A Novel Mechanism of Microvascular Dysfunction in Vascular Cognitive Impairment
Tambo, W.; Powell, K.; Wadolowski, S.; Unadkhat, P.; Chang, E. H.-Y.; Ledoux, C.; Sciubba, D.; Wang, P.; Huerta, P.; Li, C.
10.1101/2025.04.25.650644 — neuroscience — Posted on 2025-04-28
918 Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes
Majcher, A.; Bjorklund, P.; Holfeld, A.; Cinakova, A.; Zurcher, A.; Malagola, E.; Yusifov, E.; Kakava, S.; Robert, J.; Hardfeldt, J.; Hadova, K.; Kralova, E.; Levkau, B.; Othman, A.; Belgard, B.; Lauria, G.; Angelin, B.; Hornemann, T.
10.1101/2025.04.25.650588 — neuroscience — Posted on 2025-04-28
919 Mapping the functional differentiation and interactions among the inferior, medial frontal and posterior temporal cortex in semantic control
Liu, J.; Wang, X.; Zhang, H.; Yang, J.; Gao, X.; Li, Z.; Wang, Y.; Hu, Z.; Li, J.; Li, W.; Huang, Y.; Chen, J.; Zeng, L.; Weng, X.; Yuan, B.
10.1101/2025.04.28.650132 — neuroscience — Posted on 2025-04-28
920 Multi-modal screening for synergistic neuroprotection of extremely preterm brain injury
Jin, Z. R.; Corry, K. A.; Brandon, O. C.; Magoon, M. J.; Helmbrecht, H.; Moralejo, D. H.; Bassett, R.; Kolnik, S. E.; Boyle, P. M.; Juul, S. E.; Nance, E.; Wood, T. R.
10.1101/2025.04.25.650638 — neuroscience — Posted on 2025-04-29
922 Multivariate white matter microstructure alterations in older adults with coronary artery disease
Tremblay, S. A.; Potvin-Jutras, Z.; Sabra, D.; Rezaei, A.; Sanami, S.; Gagnon, C.; Intzandt, B.; Mainville-Berthiaume, A.; Wright, L.; Leppert, I. R.; Tardif, C. L.; Steele, C. J.; Iglesies-Grau, J.; Nigam, A.; Bherer, L.; Gauthier, C. J.
10.1101/2025.04.25.650626 — neuroscience — Posted on 2025-04-29
923 PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
Wang, S.; Baumert, R.; Sejourne, G.; Sivadasan Bindu, D.; Dimond, K.; Sakers, K.; Vazquez, L.; Moore, J. L.; Tan, C. X.; Takano, T.; Rodriguez, M. P.; Brose, N.; Bradley, L.; Lessing, R.; Soderling, S. H.; La Spada, A. R.; Eroglu, C.
10.1101/2023.04.09.536178 — neuroscience — Posted on 2025-04-29
926 Sharpened visual memory representations are reflected in inferotemporal cortex
Jannuzi, B. G. L.; Hacker, C. M.; Bohn, S.; Meyer, T.; Hay, M. L.; Rust, N. C.
10.1101/2025.04.28.651105 — neuroscience — Posted on 2025-04-29
927 Resting State Functional Connectivity of the Marmoset Claustrum
Holzscherer, E.; Zanini, A.; Liu, C. Y.; Everling, S.; Seminowicz, D. A.
10.1101/2025.04.25.650655 — neuroscience — Posted on 2025-04-29
929 Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons
Lai, C.-Y.; Arzavala, J.; Duarte, A. P.; Wang, S.; Li, J.; Liu, H.; Osteen, J.; Castanon, R. G.; Nery, J. R.; Powell, S. B.; Ecker, J. R.; Mukamel, E. A.; Behrens, M. M.
10.1101/2025.04.28.651094 — neuroscience — Posted on 2025-04-29
930 Dysregulation of Multiple Solute Carrier genes and Metabolic Deficits in SLC1A4-Mutant Human iPSC-Derived Hippocampal Neurons
Nayak, R.; sharma, O.; Mizrahi, L.; Shemen, A.; Tripathi, U.; Hussein, Y.; Rike, W. A.; Rosh, I.; Radzishevsky, I.; Mandel, H.; Ladewig, J.; Zaccai, T. F.; Wolosker, H.; Stern, S.
10.1101/2025.04.25.650669 — neuroscience — Posted on 2025-04-29
931 Miniaturized and accessible functional ultrasound imaging system for freely moving mice
Yang, J.; Zhou, E.; Zhu, J.; Zhu, T.; Zhao, J.; Lin, X.; Cao, Z.; Chen, Z.; An, Z.; Sun, L.; Wu, W.; Qiu, Z.
10.1101/2025.04.24.650351 — neuroscience — Posted on 2025-04-29
932 Logarithmic coding leads to adaptive stabilization in the presence of sensorimotor delays
Demarchi, L.; Coraggioso, M.; Hubert, A.; Panier, T.; Morvan-Dubois, G.; Bormuth, V.; Debregeas, G.
10.1101/2025.04.28.650940 — neuroscience — Posted on 2025-04-29
934 Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons
Essoh, A.; Gangal, H.; Huang, Z.; Chen, R.; Xie, X.; Wang, X.; Vierkant, V.; Garza, M.; Ugartemendia, L.; Secci, M. E.; Gilpin, N. W.; Justice, N. J.; Messing, R. O.; Wang, J.
10.1101/2025.04.23.650346 — neuroscience — Posted on 2025-04-29
935 Specialized parallel pathways for adaptive control of visual object pursuit
Collie, M. F.; Jin, C.; Kellogg, E.; Vanderbeck, Q. X.; Hartman, A. K.; Holtz, S. L.; Wilson, R. I.
10.1101/2025.04.23.650240 — neuroscience — Posted on 2025-04-29
936 Fetal magnetoencephalography based on optically pumped magnetometers
Corvilain, P.; Capparini, C.; Wens, V.; Fourdin, L.; Ferez, M.; Feys, O.; Delbaere, A.; Lejeune, R.; Goldman, D.; De Coninck, C.; De Tiege, X.; Bertels, J.
10.1101/2025.04.23.650121 — neuroscience — Posted on 2025-04-29
937 Alpha-synuclein phosphorylation is abundant in the non-synucleinopathy human brain
Choi, S.; Duvernay, J.; Bahrami, A.; Tittle, T.; Sani, S.; Kordower, J.; Muller, S.; Killinger, B.
10.1101/2025.04.22.649861 — neuroscience — Posted on 2025-04-29
938 Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.
Weir, K.; Lyu, P.; Kandoi, S.; An, R.; Pannullo, N.; Palaxxo, I.; Tangeman, J.; Shi, J.; DeVries, S.; Merriman, D.; Qian, J.; Blackshaw, S.
10.1101/2025.04.25.650540 — neuroscience — Posted on 2025-04-29
940 Uncovering the Neural Fingerprint of Akinetic States in a Parkinsons Disease Rodent Model
Garulli, E. L.; Merk, T.; El Hasbani, G.; Kabaoglu, B.; De Sa, R.; Behrsing, R.; Doll, D.; Schellenberger, M.; Vogt, A.; Neumann, W.-J.; Peng, Y.; Endres, M.; Harms, C.; Wenger, N.
10.1101/2025.04.22.650006 — neuroscience — Posted on 2025-04-29
942 Repeated Binge-Like Alcohol Drinking Heightens Aggression in Mice
Frier, M. D.; Biggi, N. P.; Babb, J. A.; Newman, E. L.; Covington, H. E.; Weera, M. M.
10.1101/2025.04.22.650080 — neuroscience — Posted on 2025-04-29
943 Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age
Dijsselhof, M. B. J.; Moore, C.; Amiri, S.; Tee, M.; Hilal, S.; Chen, C.; van den Born, B.-J. H.; Nordhoy, W.; Andreassen, O. A.; Westlye, L. T.; Chaturvedi, N.; Hughes, A. D.; Cash, D. M.; Schott, J. M.; Sudre, C. H.; Barkhof, F.; Kuijer, J. P. A.; Biondo, F.; Cole, J. H.; Mutsaerts, H. J. M. M.; Petr, J.
10.1101/2025.04.22.649344 — neuroscience — Posted on 2025-04-29
944 Base exchange inhibitors of SARM1 form mononucleotide adducts and activate SARM1 in vivo
Reardon, H. T.; Guijas, C.; Clapper, J. R.; Callender, J. A.; Kozina, E. M.; Sarabia, F. J.; Hutton, C.; Herbst, D. M.; Andalis, T.; Perehinets, L.; Henry, C. L.; Lebold, T. P.; Kummer, D. A.; Blankman, J. L.; Wiener, J. J. M.; Simonsen, K. B.; Samad, T. A.
10.1101/2025.04.22.649875 — neuroscience — Posted on 2025-04-29
945 The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain
PEDRAZA, M.; GRAMPA, V.; SCOTTO-LOMASSESE, S.; PUECH, J.; MUZERELLE, A.; MOHAMMAD, A.; Lebon, S.; RENIER, N.; METIN, C.; MASSON, J.
10.1101/2024.03.21.586159 — neuroscience — Posted on 2025-04-29
946 Immediately following the onset of active whisking, the input layer of barrel cortex exhibits a transient period of increased excitability that depends on prior experience
Shallow, M. C.; Tian, L.; Higashikubo, B. T.; Lin, H.; Lefton, K. B.; Chen, S.; Dougherty, J. D.; Culver, J. P.; Lambo, M. E.; Hengen, K. B.
10.1101/2024.06.04.597353 — neuroscience — Posted on 2025-04-29
947 UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis
Borisova, E.; Cuthill, K. J.; Dannenberg, R.; Koch, J.; Nowaczyk, J.; Schaub, T.; Schwark, M.; Kastelic, N.; Kupryianchyk-Schultz, I.; Kirchner, M.; Pentimalli, T. M.; Fokkens, T. J.; Stein, F.; Dietrich, C.; Quedenau, C.; Borodina, T.; Schwefel, D.; Conrad, T.; Rybak-Wolf, A.; Rajewsky, N.; Mertins, P.; Haberkant, P.; Lorenz, S.; Brose, N.; Kawabe, H.; Tarabykin, V.; Ambrozkiewicz, M. C.
10.1101/2025.04.09.646620 — neuroscience — Posted on 2025-04-29
948 Anaesthesia disrupts mesoscale signal propagation in spite of enhanced responsivity in frontal but not in parietal cortex
Dwarakanath, A.; Khalili-Ardali, M.; Gay, M.; HV, R.; Roustan, M.; Dehaene, S.; Jarraya, B.; Panagiotaropoulos, T.
10.1101/2025.04.15.648923 — neuroscience — Posted on 2025-04-29
950 Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Juul-Madsen, K.; Rudolph, I.-M.; Gomes, J. P.; Meyer, K.; Ovesen, P. L.; Gorniak-Walas, M. J.; Kokoli, M.; Telugu, N. S.; Sivertsen, M. v. T.; Sutherland, D. S.; Palmfeldt, J.; Diecke, S.; Andersen, O. M.; Selbach, M.; Willnow, T. E.
10.1101/2025.04.22.649924 — neuroscience — Posted on 2025-04-29
953 Towards individualized deep brain stimulation: A stereoencephalography-based workflow for unbiased neurostimulation target identification
Saal, J.; Kadlec, K.; Allawala, A. B.; Johnston, L.; Leriche, R.; Vatsyayan, R.; Han, Y.; Kist, A.; Di Ianni, T.; Dawes, H. E.; Chang, E. F.; Lee, A. M.; Krystal, A. D.; Moussawi, K.; Shirvalkar, P.; Sellers, K. K.
10.1101/2025.04.22.649607 — neuroscience — Posted on 2025-04-29
956 Neuralace: Manufacture, Parylene-C Coating, and Mechanical Properties
Botero Torres, J. P.; Roberts, S. M.; Mackowiak, P.; Witham, N.; Selzer, L.; Srikanthan, B.; Negi, S.; Zoschke, K.; Solzbacher, F.
10.1101/2025.04.24.650335 — neuroscience — Posted on 2025-04-27
961 Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography
Zhang, Y.; Bosch, C.; Ackels, T.; Laugros, A.; Bonnin, A.; Livingstone, J.; Waltenberg, C.; Berning, M.; Tootoonian, S.; Kollo, M.; Nathansen, A.; Rzepka, N.; Cloetens, P.; Pacureanu, A.; Schaefer, A.
10.1101/2025.04.24.650439 — neuroscience — Posted on 2025-04-27
964 Anaesthesia disrupts mesoscale signal propagation in spite of enhanced responsivity in frontal but not in parietal cortex
Dwarakanath, A.; Khalili-Ardali, M.; Gay, M.; HV, R.; Roustan, M.; Dehaene, S.; Jarraya, B.; Panagiotaropoulos, T.
10.1101/2025.04.15.648923 — neuroscience — Posted on 2025-04-27
965 Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease
Xiao, Y.; Spotorno, N.; An, L.; Bazinet, V.; Hansen, J. Y.; Strandberg, O.; Shafiei, G.; Behjat, H. H.; Funck, T.; Salvado, G.; Stomrud, E.; Smith, R.; Palmqvist, S.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Palomero-Gallagher, N.; Dagher, A.; Misic, B.; Hansson, O.; Vogel, J. W.
10.1101/2025.04.17.648358 — neuroscience — Posted on 2025-04-27
967 Patient-derived Brain Organoids Reveal Divergent Neuronal Activity Across Subpopulations of Autism Spectrum Disorder
Perets, N.; Kerem, L.; Waiskopf, N.; Horesh, N.; Goldman, I.; Avichzer, J.; Tobelaim, W.; Barashi, M.; David, L.; Tenenbaum, A.
10.1101/2025.04.27.650821 — neuroscience — Posted on 2025-04-27
970 Neural Alpha Oscillations and Auditory Temporal Coding Reveal Dual Mechanisms of Adaptation to a Cochlear Implant
Woestmann, M.; Meineke, H. M.; Schoenweiler, R.; Hollfelder, D.; Bruchhage, K.-L.; Leichtle, A.; Obleser, J.
10.1101/2025.02.17.638598 — neuroscience — Posted on 2025-04-28
972 Tanycyte Bmal1 sex-specifically regulates weight gain and hypothalamic neurogenesis in female mice
Iascone, D. M.; Pivarshev, P.; Yang, J.; Lopez Valencia, M.; Noya, S. B.; Lin, H.; Anafi, R. C.; Bedont, J. L.; Sehgal, A.
10.1101/2025.04.21.649851 — neuroscience — Posted on 2025-04-28
975 Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes
Rust, R.; Sagare, A. P.; Kisler, K.; Kim, Y.; Zhang, M.; Griffin, C.; Wang, Y.; Clementel, V.; Torres-Sepulveda, C.; TCW, J.; Zlokovic, B.; Coba, M.
10.1101/2023.06.26.546577 — neuroscience — Posted on 2025-04-28
976 Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Authier, F.; Jan, A.; Faress, I.; Skoven, C. S.; Esperon-Abril, I.; Tharmakulasingam Balasubramaniam, S.; Coquelin, K.-S.; Nyengaard, J. R.; Scavenius, C.; Attianese, B.; Sevillano-Quispe, O. G.; Eskildesen, S. F.; Thomsen, J. S.; Hansen, B.; van Aalten, D. M.
10.1101/2025.04.27.650822 — neuroscience — Posted on 2025-04-28
977 Amitraz Toxicity in Resistant Varroa Mites Can Be Increased by Inhibiting ABCB1 Transporters
Fine, J. D.; Truong, T. T.; Lucadello, M. C.; Litsey, E. M.; Lamas, Z.; Rinkevich, F.; Nicklisch, S. C.
10.1101/2025.04.23.650251 — pharmacology and toxicology — Posted on 2025-04-26
980 Biomass-derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C
Mavali Zadeh, A.; Gatto, E.; Lettieri, R.; Bokharaie, H.; Caravella, A.; D'Ottavi, C.; di Bartolomeo, E.; Domenici, F.; Sima, S.; Correia, A.; Rauniyar, K.; Klose, A.; Gounani, Z.; Laaksonen, T.; Künnapuu, J.; Jeltsch, M.
10.1101/2025.04.23.649697 — pharmacology and toxicology — Posted on 2025-04-26
981 An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
Ramalingam, M. B.; Oh, H. J.; Sears, J. D.; Chen, C.-H.; Vala, A.; Liu, S.; Talbot, K. M.; Hossain, M. A.; Brown, P. J.; Houliston, S.; Garcia Perez, J.; Li, F.; Amare, M. G.; Halfmann, P.; Smith, J.; Hirsch, A.; Arrowsmith, C. H.; Halabelian, L.; Vargason, A. M.; Counago, R. M.; Arnold, J. J.; Cameron, C. E.; Moorman, N. J.; Heise, M. T.; Willson, T. M.
10.1101/2025.04.24.650479 — pharmacology and toxicology — Posted on 2025-04-27
982 Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)
Wang, X.; Sun, J.; Ahmad, S.; Yang, D.; Li, F.; Chan, U. H.; Zeng, H.; Simoben, C. V.; Green, S. R.; Silva, M.; Houliston, S.; Dong, A.; Bolotokova, A.; Gibson, E.; Kutera, M.; Ghiabi, P.; Kondratov, I.; Matviyuk, T.; Chuprina, A.; Mavridi, D.; Lenz, C.; Joerger, A. C.; Brown, B. D.; Heath, R. B.; Yue, W. W.; Robbie, L. K.; Beyett, T. S.; Müller, S.; Knapp, S.; Harding, R.; Schapira, M.; Brown, P. J.; Santhakumar, V.; Ackloo, S.; Arrowsmith, C. H.; Edwards, A. M.; Peng, H.; Halabelian, L.
10.1101/2025.01.17.633682 — pharmacology and toxicology — Posted on 2025-04-28
986 Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment
Zhao, W.; Guo, Z.; Tian, Z.; Su, T.; Cao, G.; Qi, Z.; Qin, T.; Zhou, W.; Yang, J.; Chen, M.; Zhang, X.; Zhou, C.; Zhu, C.; Tang, M.; Tang, M.; Wu, D.; Song, M.; Guo, Y.; Qiu, L.; Liang, F.; Li, M.-J.; Geng, J.-H.; Zhao, L.-J.; Zhang, S.-J.
10.1101/2023.06.18.545504 — paleontology — Posted on 2025-04-27
987 Unveiling the Mystery of the Petroleum Genome Archive: Paleofauna Activities, Geological History, and aDNA Identification Methods in Nanyang Oilfield
Zhao, W.-Q.; Guo, Z.-Y.; Guo, Y.-Q.; Li, M.-J.; Cao, G.-Q.; Tian, Z.-Y.; Chai, R.; Qiu, L.-Y.; Zeng, J.-H.; Zhang, X.-G.; Qin, T.-C.; Yang, J.-Y.; Chen, M.-J.; Song, M.-R.; Liang, F.; Geng, J.-H.; Zhou, C.-Y.; Zhang, S.-J.; Zhao, L.-J.
10.1101/2024.12.24.630223 — paleontology — Posted on 2025-04-28
993 Cranial suture integrity is maintained by Fgfr3 in zebrafish
Pereur, R.; Marc, Y.; Lim, Y.; Schmitt, A.; Malbouyres, M.; Chessel, A.; Ruggiero, F.; Schanne-Klein, M.-C.; Legeai-Mallet, L.; Dambroise, E.
10.1101/2025.04.09.647929 — developmental biology — Posted on 2025-04-25
995 Subtle Cellular Phenotypes Inform Pathological and Benign Genetic Mutants in the Iduronidase-2 Sulfatase Gene
Viswanathan, A.; Elia, S. N.; Le, S. Q.; Hurt, S. C.; Doray, B.; Waligorski, J. E.; Kelley, K.; Buchser, W. J.; Dickson, P. I.
10.1101/2025.04.17.649412 — cell biology — Posted on 2025-04-25
996 Cannabidiol Reduces Oxycodone Self-Administration While Preserving Its Analgesic Efficacy in a Rat Model of Neuropathic Pain
Bruijnzeel, A.; Behnood-Rod, A.; Chellian, R.; Malphurs, W.; Caudle, R.; Febo, M.; Setlow, B.; Murphy, N.; Neubert, J.
10.1101/2025.04.21.649778 — pharmacology and toxicology — Posted on 2025-04-25
997 Shiny-Calorie: A context-aware application for indirect calorimetry data analysis and visualization using R
Grein, S.; Elschner, T.; Kardinal, R.; Bruder, J.; Strohmeyer, A.; Gunasekaran, K.; Witt, J.; Hermannsdottir, H.; Behrens, J.; U-Din, M.; Yu, J.; Heldmaier, G.; Schreiber, R.; Rozman, J.; Heine, M.; Scheja, L.; Worthmann, A.; Heeren, J.; Wachten, D.; Wilhelm-Juengling, K.; Pfeifer, A.; Hasenauer, J.; Klingenspor, M.
10.1101/2025.04.24.648116 — bioinformatics — Posted on 2025-04-25
998 Back to Basics: Spectrum and Peptide Sequence are Sufficient for Top-tier Mass Spectrometry Proteomics Identification
Burq, M.; Stepec, D.; Restrepo, J.; Zbontar, J.; Urazbakhtin, S.; Crampton, B.; Chinoy, R.; Tiwary, S.; Miao, M.; Cox, J.; Cimermancic, P.
10.1101/2024.08.19.606805 — bioinformatics — Posted on 2025-04-25
999 Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast co-culture as model of psoriasis
Ringheim-Bakka, T. A.; Saliani, A.; Ostbye, T.-K. K.; Mildenberger, J.; Dooley, M.; Busygina, M.; Pedersen, M. E.; Solberg, N. T.; Dalli, J.; Gammelsaeter, R.
10.1101/2025.02.20.639253 — biochemistry — Posted on 2025-04-25
1000 BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.
Heininger, H.; Feng, X.; Altunkaya, A.; Zheng, F.; Stockinger, F.; Wefers, B.; Müller, S. A.; Giesbertz, P.; Tschirner, S. K.; Shqau, D.; Adelsberger, H.; Ponomarenko, A.; Fenzl, T.; Alzheimer, C.; Lichtenthaler, S. F.; Huth, T.
10.1101/2025.04.17.648898 — animal behavior and cognition — Posted on 2025-04-25
1001 A genome-guided atlas to the composition, activity, and β-bungarotoxin dimerization in many-banded krait venom inferred by functional venomics
Uhrig, L.; Avella, I.; Schulte, L.; Hurka, S.; Dersch, L.; Eichberg, J.; Schiffmann, S.; Henke, M.; Kuch, U.; Cabrera-Orefice, A.; Hardes, K.; Vilcinskas, A.; Damm, M.; Lueddecke, T.
10.1101/2025.04.22.649985 — molecular biology — Posted on 2025-04-25
1005 Large-scale cortical networks are organised in structured cycles
van Es, M. W. J.; Higgins, C.; Gohil, C.; Quinn, A. J.; Vidaurre, D.; Woolrich, M. W.
10.1101/2023.07.25.550338 — neuroscience — Posted on 2025-04-25
1006 Human deep sleep facilitates faster cerebrospinal fluid dynamics linked to brain oscillations for sleep homeostasis and memory
Uji, M.; Li, X.; Saotome, A.; Katsumata, R.; Waggoner, R. A.; Suzuki, C.; Ueno, K.; Aritake, S.; Tamaki, M.
10.1101/2024.08.30.610454 — neuroscience — Posted on 2025-04-25
1007 Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning
Combrisson, E.; Basanisi, R.; Neri, M.; Auzias, G.; Petri, G.; Marinazzo, D.; Panzeri, S.; Brovelli, A.
10.1101/2024.09.23.614484 — neuroscience — Posted on 2025-04-25
1009 PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
Liu, F.; Liu, W.; Tan, Y.; Shang, Y.; Ling, S.; Jiang, X.; Zhang, Z.; Sun, S.; Xie, P.
10.1101/2024.08.06.606911 — cancer biology — Posted on 2025-04-25
1012 Intracortical Microstimulation Induces Rapid Microglia Process Convergence
Williams, N. P.; Kelly, A. M.; Zheng, X. S.; Vazquez, A. L.; Cui, X. T.
10.1101/2025.03.13.643075 — bioengineering — Posted on 2025-04-25
1013 Directing stem cell differentiation by chromatin state approximation
Montano-Gutierrez, L. F.; Mueller, S.; Kutschat, A. P.; Seruggia, D.; Halbritter, F.
10.1101/2025.04.24.650451 — genomics — Posted on 2025-04-25
1014 A Single-Cell Atlas Of Human Pediatric Liver Reveals Age-Related Hepatic Gene Signatures
Edgar, R. D.; Nakib, D.; Camat, D.; Chung, S.; Lumanto, P.; Atif, J.; Perciani, C. T.; Ma, X. Z.; Thoeni, C.; Selvakumaran, N.; Manuel, J.; Sayed, B.; Huysentruyt, K.; Ricciuto, A.; McGilvray, I.; Avitzur, Y.; Bader, G. D.; MacParland, S. A.
10.1101/2025.04.16.649149 — genomics — Posted on 2025-04-25
1016 DNA Methylation Dynamics of Dose-dependent Acute Exercise, Training Adaptation, and Detraining
Hariharan, M.; Patel, S.; Song, H.; Rehman, A.; Barragan, C.; Bartlett, A.; Castanon, R.; Nery, J.; Rothenberg, V.; Chen, H.; Tian, W.; Ding, W.; Wang, W.; McAdam, J.; Graham, Z.; Lavin, K.; Bamman, M.; Broderick, T.; Ecker, J.
10.1101/2025.04.22.650067 — genomics — Posted on 2025-04-25
1017 Ancient co-option of LTR retrotransposons as yeast centromeres
Haase, M. A. B.; Lazar-Stefanita, L.; Baudry, L.; Wudzinska, A.; Zhou, X.; Rokas, A.; Hittinger, C. T.; Musacchio, A.; Boeke, J. D.
10.1101/2025.04.25.647736 — evolutionary biology — Posted on 2025-04-25
1019 Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.
Joseph, J. T.; Wright, C. M.; Peixoto, E.; Khan, A.; Li, Y.; Neidigk, J. S. R.; Decker, O.; Kadali, K. R.; Imtiaz, A.; Jones, B. A.; Zhang, Y.; Shibata, E.; Gradilone, S.; Lewis, Z. A.; Contreras, R.; Sen, A.; Dutta, A.; Czaja, W.
10.1101/2024.12.19.629292 — molecular biology — Posted on 2025-04-25
1021 Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention
Sukhina, A.; Queriault, C.; Roy, S.; Hall, E.; Rome, K.; Aggarwal, M.; Nunn, E.; Weiss, A.; Nguyen, J.; Bennett, F. C.; Bailis, W.
10.1101/2024.08.19.608575 — immunology — Posted on 2025-04-25
1022 Accumbal acetylcholine signals associative salience during learning
Zhang, Z.; Costa, K. M.; Zhuo, Y.; Li, G.; Li, Y.; Schoenbaum, G.
10.1101/2025.01.06.631529 — neuroscience — Posted on 2025-04-25
1023 Neural evidence that humans reuse strategies to solve new tasks
Hall-McMaster, S.; Tomov, M. S.; Gershman, S. J.; Schuck, N. W.
10.1101/2024.06.10.598294 — neuroscience — Posted on 2025-04-25
1024 Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles
Busch, G. T.; Boe, R. H.; Li, J.; Gruener, R. F.; Arnett, M. J.; Ravindran, P. T.; Herlyn, M.; Huang, R. S.; Raj, A.
10.1101/2025.04.25.650475 — systems biology — Posted on 2025-04-25
1025 A microbiome-derived nutrient underlies tyrosine metabolism and predator avoidance in mosquito larvae
Kelley, M.; Rathore, S.; Chandrasegaran, K.; Herbert, C.; Sabile, C. E. G.; Wood, T.; Joves, J.; Palacios, A.; Susanto, E.; Uhran, M.; Ramirez, A. L.; Chen, S.-C.; Tompkin, J.; Singh, K.; Khalid, M. S.; Vinauger, C.; Buschbeck, E.; Limbach, P. A.; Benoit, J. B.
10.1101/2025.04.02.646203 — physiology — Posted on 2025-04-25
1026 Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma
Bolck, H. A.; Migh, E.; Kriston, A.; Zajac, N.; Kreutzer, S.; Totu, T.; Leary, P.; Kovacs, F.; Rutishauser, D.; Pfammatter, S.; Grossmann, J.; Litchfield, C.; Buljan, M.; Rupp, N. J.; Horvath, P.; Moch, H.
10.1101/2025.01.31.635927 — cancer biology — Posted on 2025-04-25
1027 Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning
Sakai, Y.; Sen, S.; Sugihara, T.; Kakeyama, Y.; Iwasaki, M.; Schertler, G.; Deupi, X.; Koyanagi, M.; Terakita, A.
10.1101/2024.12.12.628111 — biophysics — Posted on 2025-04-25
1029 A benchmark for large language models in bioinformatics
Sarwal, V.; Andreoletti, G.; Munteanu, V.; Suhodolschi, A.; Ciorba, D.; Bostan, V.; Dimian, M.; Eskin, E.; Wang, W.; Mangul, S.
10.1101/2023.12.19.572483 — bioinformatics — Posted on 2025-04-25
1030 BindCraft: one-shot design of functional protein binders
Pacesa, M.; Nickel, L.; Schellhaas, C.; Schmidt, J.; Pyatova, E.; Kissling, L.; Barendse, P.; Choudhury, J.; Kapoor, S.; Alcaraz-Serna, A.; Cho, Y.; Ghamary, K. H.; Vinue, L.; Yachnin, B. J.; Wollacott, A. M.; Buckley, S.; Westphal, A. H.; Lindhoud, S.; Georgeon, S.; Goverde, C. A.; Hatzopoulos, G. N.; Gonczy, P.; Muller, Y. D.; Schwank, G.; Swarts, D. C.; Vecchio, A. J.; Schneider, B. L.; Ovchinnikov, S.; Correia, B. E.
10.1101/2024.09.30.615802 — bioinformatics — Posted on 2025-04-25
1031 HybriSeq: Probe-based Device-free Single-cell RNA Profiling
Foyt, D.; Brown, D.; Zhou, S.; Moser, B.; Zhu, Q.; Gartner, Z. J.; Huang, B.
10.1101/2023.09.27.559406 — bioengineering — Posted on 2025-04-25
1032 Subcellular proteomics of Paramecium tetraurelia reveals mosaic localization of glycolysis and gluconeogenesis
Jirsova, D.; Licknack, T.; Poh, Y.-P.; Qiu, Y.; Quan, N.; Karr, T.; Chou, T.-F.; Lynch, M.; Wideman, J. G.
10.1101/2025.04.24.650466 — cell biology — Posted on 2025-04-25
1033 A Dual Homeostatic Regulation of Dry Mass and Volume Defines a Target Density in Proliferating Mammalian Cells
Srivastava, N.; Calabrese, L.; Plancke, C.; Rollin, R.; Venkova, L.; Havas, K.; Cosentino Lagomarsino, M.; Piel, M.
10.1101/2025.04.24.650395 — cell biology — Posted on 2025-04-25
1035 Aging changes the underlying mechanism of JAK2 modulation in neutrophil function
Feldmann, J. W.; Kays, M.; McGinnis, F.; Herron, E.; Sati, N.; Woods, C.; Coulibaly, A.
10.1101/2025.04.21.649782 — immunology — Posted on 2025-04-25
1036 Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy
Kapoor, R.; Kim, H.; Garlick, E.; Lima, M. A. d. R. B. F.; Ruhwedel, T.; Moebius, W.; Wolf, F.; Moser, T.
10.1101/2025.04.22.649963 — neuroscience — Posted on 2025-04-25
1037 Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy
Xie, K.; Sahlas, E.; Ngo, A.; Chen, J.; Arafat, T.; Royer, J.; Zhou, Y.; Rodriguez-Cruces, R.; Dascal, A.; Caldairou, B.; Fadaie, F.; Barnett, A.; Audrain, S.; Lariviere, S.; Caciagli, L.; Pana, R.; Weil, A. G.; Grova, C.; Frauscher, B.; Schrader, D. V.; Zhang, Z.; Concha, L.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B. C.
10.1101/2025.04.24.650457 — neuroscience — Posted on 2025-04-25
1041 Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course
The Augsburg BIO474 Consortium, ; Aburaide, S.; Ahmed, S.; Chamberlain, M.; Deleon, Y.; Elewa, A.; Millan, L.; Hookom, A.; Juen, E.; Katasi, D.; Lee, B.; Meyer, S.; Shaw, M.; Smith, D.; Vassallo, A.; Wangmo, T.; Wolfson, D.; Xiong, P.; Yaeger, L.
10.1101/2025.04.23.650323 — scientific communication and education — Posted on 2025-04-25
1043 TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma
Asad, M.; Inocencio, J.; Mitrasinovic, S.; Aoki, M.; Crisman, C.; Lasala, P.; Eskandar, E.; Guha, C.; Zang, X.; Parney, I. F.; Himes, B. T.
10.1101/2025.04.24.648993 — cancer biology — Posted on 2025-04-25
1045 Fluorescence Characterization of Extracellular Vesicles using Single-Molecule Confocal Microscopy
Zhao, T.; Pelegrina-Hidalgo, N.; Edwards, D. C.; Bak, K. M.; Karmakar, U.; Fernando, A. J.; Vendrell, M.; Rossi, A. G.; Kunath, T.; Cockroft, S. L.; Saleeb, R. S.; Horrocks, M. H.
10.1101/2025.04.21.649767 — biophysics — Posted on 2025-04-25
1048 Tumour-derived Ilp8 and Upd3 control intestinal progenitor cells depletion during cachexia in Drosophila larvae
Falconi, J.; Rodriguez-Vazquez, M.; Strobel, K.; Jahannault-Talignani, C.; Heron-Milhavet, L.; Lassus, P.; Geminard, C.; Djiane, A.
10.1101/2025.04.21.649791 — developmental biology — Posted on 2025-04-25
1049 OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus
Ismail, A. M.; Saha, A.; Morrissey, K. A.; Lundquist, D.; Garcia, E.; Balne, P.; Cannon, J. L.; Chodosh, J.; Rajaiya, J.
10.1101/2025.04.23.650321 — cell biology — Posted on 2025-04-25
1050 Dystrophin Dp71 is essential for the development and function of macrophages
Chira, N.; Swatler, J.; Manousopoulou, A.; Rumney, R. M. H.; Hajto, J.; Oksiejuk, A.; Garay Baquero, D. J.; Rog, J.; White, C. H.; Hinz, S.; Alnassar, N.; Young, C.; Arkle, S.; Korostynski, M.; Kozlowska, E.; Garbis, S. D.; Gorecki, D. C.
10.1101/2025.04.24.650386 — cell biology — Posted on 2025-04-25
1052 Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder
Liu, X.-M.; Pribiag, H.; Misri, D.; Kim, K.; Mandell, K. P.; Song, B. J.; Graykowski, D.; Seidel, O.; Hartley, N. D.; Herrera, M.; Xu, H. J.; Tegtmeyer, M.; Zhang, Y.-L.; Cui, L.; Clark, N.; Huang, W.-C.; Adeleye, J.; Dennis, C.; Dailey, L.; Deik, A.; Inunciaga, L.; Mashin, E.; Simmons, S. K.; Pan, J. Q.; Nehme, R.; Keshishian, H.; Carr, S. A.; Fu, Z.; Levin, J. Z.; Clish, C. B.; Sheng, M.
10.1101/2025.04.25.650548 — cell biology — Posted on 2025-04-25
1054 Targeting ROCK Signaling Mitigates Influenza Virus-Induced Fibrogenesis in Human Airway Organoids
ROTHAN, H.; Mostafa, A.; Bayoumi, M.; Ye, C.; Barre, R.; Allue Guardia, A.; Nogales, A.; Torrelles, J. B.; Martinez-Sobrido, L. B.
10.1101/2025.04.21.649854 — microbiology — Posted on 2025-04-25
1056 Immune Composition of the Mononuclear Cell Fraction of Human Umbilical Cord Blood
Kikuta, K.; Lee, E.; Menezes, T.; Fung, H. F.; Amorin, A.; Agrawal, A.; Roth, T.; Porteus, M.
10.1101/2025.04.21.649733 — immunology — Posted on 2025-04-25
1062 Genomic erosion through the lens of comparative genomics
Wang, X.; Fontsere, C.; Caballero, X. A.; Nielsen, S. D.; Groombridge, J.; Hansson, B.; van Oosterhout, C.; Pacheco, C.; Morales, H. E.
10.1101/2025.03.28.645899 — genomics — Posted on 2025-04-24
1064 Systematic analysis of CDR contacts and sequence constraints between T cell receptor αβ chains.
Milighetti, M.; Nagano, Y.; Henderson, J.; Hershberg, U.; Tiffeau-Mayer, A.; Bitbol, A.-F.; Chain, B.
10.1101/2024.05.24.595718 — immunology — Posted on 2025-04-24
1065 Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies
Wagner-Carena, J. A.; Kate, S.; Riordan, T.; Abbasi-Asl, R.; Aman, J.; Amster, A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Buice, M. A.; Bumbarger, D. J.; Collman, F.; da Costa, N. M.; Denman, D. J.; de Vries, S. E.; Joyce, E.; Kapner, D.; King, C. W.; Larkin, J. D.; Lecoq, J.; Mahalingam, G.; Millman, D.; Molter, J.; Morrison, C.; Reid, R. C.; Schneider-Mizell, C. M.; Daniel, S.; Suckow, S.; Takasaki, K. T.; Torres, R.; Vumbaco, D.; Waters, J.; Wyrick, D. G.; Yin, W.; Zhuang, J.; Takeno, M.; Mihalas, S.; Berteau, S.
10.1101/2025.04.24.649900 — neuroscience — Posted on 2025-04-24
1067 Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype
Bortolozzi, A.; Miquel Rio, L.; Jerico-Escolar, J.; Sarries-Serrano, U.; Yanes-Castilla, C.; Paz, V.; Torres-Lopez, M.; Argibay, U.; Munoz, E.; Lopez-Gil, X.
10.1101/2025.04.24.650442 — neuroscience — Posted on 2025-04-24
1070 Characterization of Human Anterior Neural Organoids as a Model for Investigating Cohen Syndrome
Prasad, R.; Lee, J.-H.; Lee, D.-Y.; Lee, Y.; Lee, J.; Park, S.-H.; Ryu, J. R.; Lee, B.; Choi, S.; Choi, J.; Cho, I.-J.; An, J.-Y.; Vacca, F.; Ansar, M.; Kim, H. J.; Kim, M.; Sun, W.
10.1101/2025.04.23.650357 — neuroscience — Posted on 2025-04-24
1073 PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape
Conley, E. A.; Lisowski, C. M.; Schaefer, K. G.; Davison, H. C.; Baguio, J.; Kosztin, I.; King, G.
10.1101/2024.05.06.592664 — biophysics — Posted on 2025-04-24
1074 Reference-guided genome assembly at scale using ultra-low-coverage high-fidelity long-reads with HiFiCCL
Jiang, Z.; Pan, W.; Gao, R.; Hu, H.; Gao, W.; Zhou, M.; Yin, Y.-H.; Qian, Z.; Jin, S.; Wang, G.
10.1101/2025.04.20.649739 — bioinformatics — Posted on 2025-04-24
1075 K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming
Milanesi, M.; Urbinati, C.; Zimmermann, L.; Oreste, P.; Zani, A.; Caruso, A.; Caccuri, F.; Laketa, V.; Chlanda, P.; Wade, R. C.; Rusnati, M.; Paiardi, G.
10.1101/2025.04.23.650164 — biochemistry — Posted on 2025-04-24
1076 Targeted long-read RNA sequencing reveals the complexity of CLN3 transcription and the consequences of the most common 1-kb deletion in patients with juvenile CLN3 disease
Minnis, C. J.; Zhang, H.-Y.; Gustavsson, E.; Lee, J.; Anderson, C.; Gardner, E.; Schulz, A.; Nickel, M.; Arno, G.; Jurkute, N.; Webster, A. R.; Gammaldi, N.; Santorelli, F. M.; Gissen, P.; Mills, P.; Ryten, M.; Mole, S. E.
10.1101/2025.04.24.650398 — genetics — Posted on 2025-04-24
1077 Parallel evolution of full-length genomes in a long-term evolution experiment with phage ΦX174
Bons, E.; Chabas, H.; MacDonald, H.; Escalera Ledermann, A.; Ochsner, N.; Angst, D. C.; Bonhoeffer, S.; Regoes, R. R.
10.1101/2025.04.22.649699 — evolutionary biology — Posted on 2025-04-24
1079 Group size influences behavioral plasticity in responses to thermoregulation-foraging trade-offs by a socially cohesive bird
Rozen-Rechels, D.; Papageorgiou, D.; Ogino, M.; Nyaguthii, B.; Buschhausen, N.; Hansen Wheat, C.; Klarevas-Irby, J. A.; Njoroge, P.; Farine, D. R.
10.1101/2025.04.24.650232 — ecology — Posted on 2025-04-24
1080 Complementary cortical and striatal encoding of locomotor preparation and performance
Singla, D.; Yang, L.; Weakley, A. S.; Davidoff, D.; Kao, J. C.; Masmanidis, S. C.
10.1101/2025.04.24.650464 — neuroscience — Posted on 2025-04-24
1081 A genome-guided atlas to the composition, activity, and β-bungarotoxin dimerization in many-banded krait venom inferred by functional venomics
Uhrig, L.; Avella, I.; Schulte, L.; Hurka, S.; Dersch, L.; Eichberg, J.; Schiffmann, S.; Henke, M.; Kuch, U.; Cabrera-Orefice, A.; Hardes, K.; Vilcinskas, A.; Damm, M.; Lueddecke, T.
10.1101/2025.04.22.649985 — molecular biology — Posted on 2025-04-24
1082 The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans
Weber, J.; Ponse, N. L. D.; Zhu, X.; Rios Carrasco, M.; Han, A. X.; Funk, M.; Lin, T.-H.; Gabarroca Garcia, A.; Spruit, C. M.; Yu, W.; Zhang, D.; Wilson, I. A.; Richard, M.; Boons, G.-J.; de Vries, R. P.
10.1101/2025.04.24.650378 — microbiology — Posted on 2025-04-24
1083 A refined low-dose murine model of Mycobacterium ulcerans infection to assess integrated immune networks in Buruli ulcer pathogenesis
Muhi, S.; Foo, I. J. H.; Kedzierski, L.; Porter, J. L.; McQuilten, H. A.; Howden, B.; Kedzierska, K.; Buultjens, A. H.; Chua, B. Y.; Stinear, T. P.
10.1101/2025.04.23.650345 — microbiology — Posted on 2025-04-24
1085 Cell cycle-coupled transcriptional network orchestrates human B cell fate bifurcation
Pease, N. A.; Fan, J.; Keshari, S.; Stratton, J.; Gerges, P.; Ann Varghese, B.; Nampoothiri VP, N.; McGinnnis, C. S.; Zhang, W.; Geirlack, S. B.; Swaminathan, T.; Sachan, A.; Manakkat Vijay, G.; Mena Hernandez, L.; Heidari Rarani, Z.; Macedo, C.; Metes, D.; Satpathy, A. T.; Jain, A. K.; Sahni, N.; Stallaert, W.; Das, J.; Singh, H.
10.1101/2025.04.23.649973 — immunology — Posted on 2025-04-24
1086 Large Language Models Reveal the Neural Tracking of Linguistic Context in Attended and Unattended Multi-Talker Speech
Puffay, C.; Mischler, G.; Choudhari, V.; Vanthornhout, J.; Bickel, S.; Mehta, A. D.; Schevon, C. A.; McKhann, G. M.; Van hamme, H.; Francart, T.; Mesgarani, N.
10.1101/2025.04.24.648897 — neuroscience — Posted on 2025-04-24
1087 Engineering microbial consortia for distributed signal processing
Duncker, K. E.; Shende, A. R.; Shyti, I.; Ruan, A.; D'Cunha, R.; Ma, H. R.; Venugopal Lavanya, H.; Liu, S.; Gottel, N.; Anderson, D. J.; Gunsch, C. K.; You, L.
10.1101/2025.04.23.650302 — synthetic biology — Posted on 2025-04-24
1093 Global mapping of thioredoxin interacting proteins in Neurospora crassa
Bidondo, L.; Drula, E.; GAILLARD, j.-c.; Armengaud, J.; Berrin, J.-G.; Rosso, M.-N.; Tarrago, L.
10.1101/2025.04.24.650474 — microbiology — Posted on 2025-04-24
1094 Rapid Assembly and Functional Differentiation of the Soil Surface Microbiome in Temperate Agricultural soil
O'Grady, C. J.; Hilton, S.; Picot, E.; Raguideau, S.; Quince, C.; van der Gast, C.; Bending, G. D.
10.1101/2025.04.24.650463 — microbiology — Posted on 2025-04-24
1096 Harnessing machine learning to predict antibiotic susceptibility in Pseudomonas aeruginosa biofilms
Vergauwe, F.; De Waele, G.; Sass, A.; Highmore, C.; Hanrahan, N.; Cook, Y.; Lichtenberg, M.; Cnockaert, M.; Vandamme, P.; Mahajan, S.; Webb, J.; Van Nieuwerburgh, F.; Bjarnsholt, T.; Waegeman, W.; Coenye, T.
10.1101/2025.04.24.650389 — microbiology — Posted on 2025-04-24
1098 Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates
Turner, A. H.; Jaffrani, S. A.; Kubinski, H. C.; Ajayi, D. P.; Owens, M. B.; McTigue, M. P.; Fanuele, C. D.; Appenzeller, C. L.; Despres, H. W.; Schmidt, M. M.; Crothers, J. W.; Bruce, E. A.
10.1101/2025.04.23.650275 — microbiology — Posted on 2025-04-24
1101 Nickel-NTA lipid-monolayer affinity grids allow for high-resolution structure determination by cryo-EM
Skrajna, A.; Robinson, E.; Cannon, K.; Sarsam, R.; Ouellette, R. G.; Brennwald, P.; McGinty, R. K.; Strauss, J. D.; Baker, R. W.
10.1101/2025.04.24.650495 — biochemistry — Posted on 2025-04-24
1102 Giardia duodenalis: Base excision repair pathway enzyme FEN1 carries out catalytic activities pertaining to NER pathway
Garcia-Lepe, U. O.; Tomas-Morales, S. G.; Izaguirre-Hernandez, M. T.; Bazan-Tejeda, M. L.; Bermudez-Cruz, R. M.
10.1101/2025.04.23.650334 — biochemistry — Posted on 2025-04-24
1105 Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation
Lenz, J.; Schmelzer, L.; Forne, I.; Nist, A.; Imhof, A.; Stiewe, T.; Brehm, A.
10.1101/2025.04.22.649938 — molecular biology — Posted on 2025-04-24
1108 Discovery of a novel antibiotic class targeting the enolase of Acinetobacterbaumannii
Molina Panadero, I.; Moreno Rodriguez, A.; de la Cruz, M.; Sanchez, P.; Tomas Gallardo, L.; Samernate, T.; Sencanski, M.; Glisic, S.; Genilloud, O.; Nonejuie, P.; Perez Pulido, A. J.; Hmadcha, A.; Smani, Y.
10.1101/2025.04.23.650324 — microbiology — Posted on 2025-04-24
1115 In Vitro and Viral Evolution Convergence Reveal the Selective Pressures Driving Omicron Emergence
Shoshany, A.; Tian, R.; Blanco, M. P.; Hruska, A.; Konar, A.; Baxova, K.; Zoler, E.; Mokrejs, M.; Schreiber, G.; Zahradnik, J.
10.1101/2025.04.23.650148 — evolutionary biology — Posted on 2025-04-24
1117 Characterization of betacoronavirus HKU-1 and OC43 internal proteins using a prototypic coronavirus
Gunawardene, C. D.; Pandey, I.; Chatterjee, S.; Penaflor-Tellez, Y.; Odle, A.; Messyasz, A.; Rajsbaum, R.; Sariol, A.; Wong, L.-Y. R.
10.1101/2025.04.23.650176 — microbiology — Posted on 2025-04-24
1120 A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells
Pawar, N. R.; Wade, H. M.; Jackson, Z.; Poungpeth, N.; Mitchell, A. V.; Jewell, C. P.; Chan, D.; Robey, R. W.; Batista, P. J.; Jenkins, L. M.; Gottesman, M. M.
10.1101/2025.04.21.649594 — cancer biology — Posted on 2025-04-24
1121 Tube feet dynamics drive adaptation in sea star locomotion
Deridoux, A.; Heydari, S.; Gorb, S.; Kanso, E.; Flammang, P.; Gabriele, S.
10.1101/2025.04.22.649740 — biophysics — Posted on 2025-04-24
1125 The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle
Engler, S.; Delhommel, F.; Dodt, C.; Lopez, A.; Faust, O.; Napolitano, V.; Popowicz, G. M.; Rosenzweig, R.; Sattler, M.; Buchner, J.
10.1101/2025.04.24.648904 — biochemistry — Posted on 2025-04-24
1127 Amniotic fluid extracellular vesicle properties evolve with gestational age and reflect fetal development
Atukorala, I.; Beard, S.; Ang, C.-S.; Brown, H. G.; Raghavan, S.; de Alwis, N.; Fato, B.; Binder, N.; Hannan, N.; Hui, L.
10.1101/2025.04.23.649052 — developmental biology — Posted on 2025-04-24
1129 Characterization of iGABASnFR2 for in vivo mesoscale imaging of intracortical GABA dynamics
Rezaei, E.; Tohidi, S.; Nazari-Ahangarkolaee, M.; Karimi Abadchi, J.; Michelson, N. J.; Murphy, T. H.
10.1101/2025.04.22.649661 — neuroscience — Posted on 2025-04-24
1131 Inter-Spheroid Proximity and Matrix Remodeling Determine CAF-Mediated Cancer Cell Invasion
Mehta, P. P.; Bordoloi, A. D.; Ravensbergen, C.; David, K.; Liefers, G.-J.; Mesker, W.; ten Dijke, P. P.; Boukany, P.
10.1101/2025.04.24.648914 — cancer biology — Posted on 2025-04-24
1132 Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia
Gravenmier, C.; Marzban, S.; Tang, Y.-H.; Gillis, N.; Shah, B. D.; Moscinski, L.; Zhang, L.; West, J.
10.1101/2025.04.21.649796 — cancer biology — Posted on 2025-04-24
1133 2H MRI-based quantification of leucine uptake in glioblastoma multiforme
McClendon, S.; Ge, X.; Song, K.-H.; Grief, D.; Fortin Ensign, S. P.; Kodibagkar, V. D.; Hu, L. S.; Garbow, J. R.; Beeman, S. C.
10.1101/2025.04.23.648848 — cancer biology — Posted on 2025-04-24
1134 BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature
Yan, J.; Zhu, J.; Yang, Y.; Liu, Q.; Zhang, K.; Zhang, Z.; Liu, X.; Zhang, B.; Gao, K.; Xiao, J.; Chen, E.
10.1101/2025.04.22.648951 — bioinformatics — Posted on 2025-04-24
1136 High-quality metagenome assembly from nanopore reads with nanoMDBG
Benoit, G.; James, R.; Raguideau, S.; Alabone, G.; Goodall, T.; Chikhi, R.; Quince, C.
10.1101/2025.04.22.649928 — bioinformatics — Posted on 2025-04-24
1137 Advancing Pediatric and Longitudinal DNA Methylation Studies with CellsPickMe, an Integrated Blood Cell Deconvolution Method
Fu, M. P.; Edwards, K.; Navarro-Delgado, E. I.; Merrill, S. M.; Kitaba, N. T.; Konwar, C.; Mandhane, P.; Simons, E.; Subbarao, P.; Moraes, T. J.; Holloway, J. W.; Turvey, S. E.; Kobor, M. S.
10.1101/2025.04.22.649907 — bioinformatics — Posted on 2025-04-24
1138 Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis
Rencken, S.; Tushev, G.; Hain, D.; Ciirdaeva, E.; Simakov, O.; Laurent, G.
10.1101/2025.04.22.649952 — genomics — Posted on 2025-04-24
1139 Gene turnover and contingency facilitated the repeated evolution of C4 photosynthesis in grasses
Pereira, L.; Alenazi, A. S.; Mian, S.; Leitch, I. J.; Christin, P.-A.; Osborne, C. P.; Dunning, L. T.
10.1101/2025.04.23.650007 — evolutionary biology — Posted on 2025-04-24
1140 Biased estimates of phylogenetic branch lengths resulting from the discretised Gamma model of site rate heterogeneity
Ferretti, L.; Golubchik, T.; Di Lauro, F.; Ghafari, M.; Villabona-Arenas, J.; Atkins, K. E.; Fraser, C.; Hall, M. D.
10.1101/2024.08.01.606208 — evolutionary biology — Posted on 2025-04-24
1141 A large-scale phylogeny of replication initiation proteins illuminates plasmid macroevolutionary landscape
Nishimura, Y.; Kaneko, K.; Kamijo, T.; Isogai, N.; Tokuda, M.; Xie, H.; Tsuda, Y.; Hirabayashi, A.; Moriuchi, R.; Dohra, H.; Kimbara, K.; Suzuki-Minakuchi, C.; Nojiri, H.; Suzuki, H.; Suzuki, M.; Shintani, M.
10.1101/2024.09.03.610885 — microbiology — Posted on 2025-04-24
1142 Gut-Germline Axis: A Reproductive Endosymbiont's Adaptation is Modulated by the Gut Microbiome
Imchen, M.; Kaur, R.; Luo, D. H. Z.; Bitman, M. W.; Lefoulon, E.; McGarry, A.; Bordenstein, S. R.; Bordenstein, S. R.
10.1101/2024.09.10.611936 — microbiology — Posted on 2025-04-24
1145 Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling
Bellofatto, K.; Lebreton, F.; Hassany, M.; Hanna, R.; Bignard, J.; Marteyn, A.; Mar Fonseca, L.; Campo, F.; Olgasi, C.; Wolf-van Buerck, L.; Honarpisheh, M.; MARTINEZ DE TEJADA WEBER, B.; Follenzi, A.; Citro, A.; Piemonti, L.; THAUNAT, O.; Seissler, J.; COMPAGNON, P.; cohen, m.; BERISHVILI, E.; VANGUARD consortium,
10.1101/2025.04.19.647461 — bioengineering — Posted on 2025-04-24
1147 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)
Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.
10.1101/2024.12.06.627158 — genomics — Posted on 2025-04-24
1149 Dual transcranial electromagnetic stimulation of the precuneus-hippocampus network boosts human long-term memory
Borghi, I.; Mencarelli, L.; Maiella, M.; Casula, E. P.; Ferraresi, M.; Candeo, F.; Savastano, E.; Assogna, M.; Bonni, S.; Koch, G.
10.1101/2024.10.25.620008 — neuroscience — Posted on 2025-04-24
1151 In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance
Mears, K.; Ibrahim, K.; Allen, P. M.; Chinai, J. M.; Avila, O. L.; Muscato, A. J.; Late-Reticker, S. K.; Rojas, A.; Knudson, N. H.; Chao, C.-C.; Yates, K. B.; Manguso, R. T.
10.1101/2025.04.23.645810 — bioengineering — Posted on 2025-04-24
1154 Lymphatic dissemination drives systemic invasion by diverse clinically relevant extracellular bacterial pathogens
Siggins, M. K.; Kwong Li, H.; Huse, K. K.; Pearson, M.; Openshaw, P. J.; Jackson, D. G.; Sriskandan, S.
10.1101/2025.04.21.649860 — immunology — Posted on 2025-04-24
1155 Structural insights into allosteric mechanism of glycine transporter-mediated analgesia
Cantwell Chater, R. P.; Peiser-Oliver, J.; Pati, T. K.; Quinn, A. S.; Lotsaris, I.; Frangos, Z. J.; Tischer, A. E.; Williams-Noonan, B. J.; O'Mara, M. L.; Michaelides, M.; Mohammadi, S. A.; Cioffi, C. L.; Vandenberg, R. J.; Shahsavar, A.
10.1101/2025.04.21.649698 — neuroscience — Posted on 2025-04-24
1156 BRCA2 reversion mutation-independent resistance to PARP inhibition in prostate cancer through loss of function perturbations in the DNA pre-replication complex
Pappas, K. J.; Ferrari, M.; Smith, P.; Nandakumar, S.; Khan, Z.; Young, S. B.; LaClair, J.; Russo, M. V.; Huang-Hobbs, E.; Schultz, N.; Abida, W.; Karthaus, W.; Jasin, M.; Sawyers, C.
10.1101/2025.04.20.649668 — cancer biology — Posted on 2025-04-24
1157 Chromosomal Aneuploidy in Normal, Non-Neuronal Brain Nuclei of Glioblastoma Patients is Not a Cancer Driver
Montagna, C.; Albert, O.; Sun, S.; Lin, J.-R.; Lee, M.; Chan, C.; Maslov, A. Y.; Ellerby, L.; Huttner, A.; Zhang, Z.; Vijg, J. V.
10.1101/2025.04.22.649812 — cancer biology — Posted on 2025-04-24
1159 SCassist: An AI Based Workflow Assistant for Single-Cell Analysis
Nagarajan, V.; Shi, G.; Arunkumar, S.; Liu, C.; Gopalakrishnan, J.; Nath, P. R.; Jang, J.; Caspi, R.
10.1101/2025.04.22.650107 — bioinformatics — Posted on 2025-04-24
1160 Shiny-Calorie: A context-aware application for indirect calorimetry data analysis and visualization using R
Grein, S.; Elschner, T.; Kardinal, R.; Bruder, J.; Strohmeyer, A.; Gunasekaran, K.; Witt, J.; Hermannsdottir, H.; Behrens, J.; U-Din, M.; Yu, J.; Heldmaier, G.; Schreiber, R.; Rozman, J.; Heine, M.; Scheja, L.; Worthmann, A.; Heeren, J.; Wachten, D.; Wilhelm-Juengling, K.; Pfeifer, A.; Hasenauer, J.; Klingenspor, M.
10.1101/2025.04.24.648116 — bioinformatics — Posted on 2025-04-24
1162 Meta-AlignNN: A meta-learning framework for stable brain-computer interface performance across subjects, time, and tasks
Zou, Y.; Liu, K.; Zhang, C.; Ling, Y.; Wang, F.; Li, M.; Chen, Y.; Li, M.; Guan, S.; He, Z.; Li, C. T.
10.1101/2025.04.20.649482 — bioengineering — Posted on 2025-04-24
1163 Mesoscopic whole-brain T2*-weighted and associated quantitative MRI in healthy humans at 10.5 T
Liu, J.; Van Gelderen, P.; de Zwart, J. A.; Duyn, J. H.; Huang, Y.; Grant, A.; Auerbach, E.; Waks, M.; Lagore, R. L.; Delabarre, L.; Tarakameh, A. S.; Eryaman, Y.; Adrian, G.; Ugurbil, K.; Wu, X.
10.1101/2025.04.21.649819 — bioengineering — Posted on 2025-04-24
1167 Large Animal Epilepsy Model Platform: Kainic Acid Porcine Model of Mesial Temporal Lobe Epilepsy
Mivalt, F.; Maltais, D.; Kim, I.; Kim, J.; Began, P.; Duque Lopez, A.; Krakorova, V.; Winter, B.; Gregg, N. M.; Montonye, D.; Gow, C.; Miller, K. J.; Van Gompel, J.; Leyde, K.; Kremen, V.; Worrell, G. A.
10.1101/2025.01.22.634312 — neuroscience — Posted on 2025-04-24
1168 Dissociating stimulus encoding and task demands in ECoG responses from human visual cortex
Qadir, Z.; Huang, H.; Ozker, M.; Yoshor, D.; Beauchamp, M. S.; Kay, K.; Hermes, D.
10.1101/2025.04.23.648016 — neuroscience — Posted on 2025-04-24
1169 Heme-NO dilates arteries via mobilization of NO moieties from a vascular intracellular NO store
Liu, T.; Zhang, M.; Zhu, L.; Ke, H.; Souza, A. d.; Li, Q.; Castella, D.; Lehnert, N.; Zhang, L.; Blood, A. B.
10.1101/2025.04.22.650128 — physiology — Posted on 2025-04-24
1170 DeltaBreed: A BrAPI-centric breeding data information system
Yarnes, S. C.; Palladino, N.; Meidlinger, D. J.; Philips, D. R.; Sweeney, H. M.; Mustafa, S.; Mandych, M. L.; Bouabane, S.; Parsons, T. E.; Slonecki, T. J.; Zhao, D.; Rife, T. W.; Ellerbrock, B. J.; Courtney, C.; Selby, P.; Flores-Gonzalez, M.; Mueller, L. A.; Aparicio, J. S.; Al-Sham'aa, K.; Raubach, S.; Beil, C. T.; Sheehan, M. J.; Meng Lin, Edwin Reidel, Tyr Wiesner-Hanks, Arlyn J Ackerman, Alexandra M Casa, Alexander M Sandercoc,
10.1101/2025.04.23.650200 — bioinformatics — Posted on 2025-04-24
1172 Transcription-based identification of uncharacterized genes in the human immune response
Vorsteveld, E. E.; Kersten, S.; Kaffa, C.; Simons, A.; 't Hoen, P. A. C.; Netea, M. G.; Hoischen, A.
10.1101/2025.04.22.646545 — genomics — Posted on 2025-04-24
1174 Close-Up of vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM
Nair, A.; Nair, A.; Stock, P.; Jain, A.; Somerville, E.; Sanyal, A.; Kirchhausen, T.
10.1101/2025.04.23.650353 — cell biology — Posted on 2025-04-24
1176 Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein
Freuchet, A.; Johansson, E.; Frazier, A.; Litvan, I.; Goldman, J. G.; Alcalay, R. N.; Sulzer, D.; Lindestam Arlehamn, C. S.; Sette, A.
10.1101/2025.04.21.649867 — neuroscience — Posted on 2025-04-24
1177 Behavioral deficits and exacerbated hemodynamics during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEϵ4 and Trem2*R47H
izydorczak, M.; Oumov, M.; Udhwani, M. V.; Fostok, F.; Coronas-Samano, G.; Sanganahalli, B. G.; Herman, P.; Hyder, F.; Verhagen, J. V.
10.1101/2025.04.20.649712 — neuroscience — Posted on 2025-04-24
1178 T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease
Johansson, E.; Freuchet, A.; Williams, G. P.; Michealis, T.; Frazier, A.; Litvan, I.; Goldman, J. G.; Alcalay, R. N.; Standaert, D. G.; Amara, A. W.; Stover, N.; Fon, E. A.; Postuma, R. B.; Sidney, J.; Sulzer, D.; Lindestam Arlehamn, C. S.; Sette, A.
10.1101/2025.04.21.649871 — neuroscience — Posted on 2025-04-24
1179 Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.
Suresh, A.; Kourdougli, N.; Buth, J. E.; Sanchez-Leon, C. A.; Wall, L. T.; Tran, A. T.; Miranda-Rottmann, S.; Araya, R.; Gandal, M. J.; Portera-Cailliau, C.
10.1101/2025.04.21.649817 — neuroscience — Posted on 2025-04-24
1180 Proteomic profiling of bacterial extracellular vesicles for exploring ovarian cancer biomarkers
Asano-Inami, E.; Yokoi, A.; Yoshida, K.; Taki, K.; Kitagawa, M.; Suzuki, K.; Uekusa, R.; Nagao, Y.; Yoshikawa, N.; Niimi, K.; Yamamoto, Y.; Kajiyama, H.
10.1101/2025.04.20.649473 — cancer biology — Posted on 2025-04-24
1181 Spatial control of karyopherin binding avidity within NPC mimics revealed by designer FG-Nucleoporins
de Vries, H. W.; Barth, A.; Fragasso, A.; Otto, T. A.; van der Graaf, A.; van der Sluis, E. O.; van der Giessen, E.; Veenhoff, L. M.; Dekker, C.; Onck, P. R.
10.1101/2025.04.21.649908 — biophysics — Posted on 2025-04-24
1184 Label-free quantification in the Crux toolkit
Acquaye, F. L. N. A.; Wen, B.; Grant, C. E.; Noble, W. S.; Kertesz-Farkas, A.
10.1101/2025.04.21.649897 — bioinformatics — Posted on 2025-04-24
1186 A Continuously Oxygenated Macroencapsulation System Enables High-Density Packing and Delivery of Insulin-Secreting Cells
Pham, T. T.; Tran, P. L.; Tempelman, L. A.; Stone, S. G.; Piccirillo, C.; Li, A.; Flanders, J. A.; Ma, M.
10.1101/2025.04.21.649806 — bioengineering — Posted on 2025-04-24
1187 Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell response
Wei, C.; Zhu, Y.; Lu, X.; Goodier, K. D.; Yu, D.; Liu, X.; Choy, J.; Tellez Calderon, A.; Ma, J.; Su, Y.; Lin, J.; Li, S.; Schneck, J. P.; Murphy, S. C.; Mao, H.-Q.
10.1101/2025.04.21.649878 — bioengineering — Posted on 2025-04-24
1189 Genomic and Immunogenomic Profiling of Extramedullary Acute Myeloid Leukemia Reveals Actionable Clonal Branching and Frequent Immune Editing
Collignon, C.; Hansen, T.; Hercus, C.; Ruzinova, M. B.; Guepin, G. R.; Bonmati, C.; Rubio, M. T.; Feugier, P.; Gaudfrin, M.; Sartelet, H.; Divoux, M.; Muller, M.; Heath, S.; Uy, G.; Spencer, D.; Chen, D.; Pagliuca, S.; Ferraro, F.
10.1101/2025.04.18.649610 — genomics — Posted on 2025-04-24
1190 A novel transgenic reporter to study vertebrate epigenetics
Marvel, M.; Gore, A. V.; Taimatsu, K.; Castranova, D.; Margolin, G.; Goldstein, A.; Swearer, A. A.; Carpinello, O.; Combs, J.; Detels, M.; Greenspan, L. J.; Parker, A.; Kim, Y. A.; Khor, J. M.; Davis, A. E.; Kenton, M. I.; Prevedel, J.; Barnes, K.; Iben, J. R.; Li, T.; Faucz, F. R.; Dale, R.; Weinstein, B. M.
10.1101/2025.04.21.649821 — genomics — Posted on 2025-04-24
1193 Beige fat appearance during lipoatrophy reveals trade-offs between metabolic homeostasis and female fertility
Anaya, E. S.; Dion, W.; Saha, P.; Cox, A. R.; de Groot, E.; Ahmed, A.; Felix, J. B.; Zhu, B.; Pangas, S. A.; Hartig, S. M.
10.1101/2025.04.21.649835 — cell biology — Posted on 2025-04-24
1194 The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance
Koh, A.; Bokman, E.; Gavrikov, A.; Rodriguez, J.; Chen, C.; Zaslaver, A.; Brown, A. E. X.
10.1101/2025.04.20.649642 — neuroscience — Posted on 2025-04-24
1195 FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction
Spann, R. A.; Kim, S. Q.; Khan, M. S. H.; Albarado, D. A.; Fernandez-Kim, S. O.; Berthoud, H.-R.; McDougal, D. H.; Münzberg, H.; He, Y.; Yu, S.; Morrison, C. D.
10.1101/2025.04.19.649640 — neuroscience — Posted on 2025-04-24
1197 TDP-43 toxic gain of function links ALS/FTLD-TDP and Alzheimer's Disease through splicing
Van Zuiden, W.; Meimoun, T. D.; Bar, C.; Siany, A.; Moshe, L.; Yacovzada, N. S.; Weizman, E.; Neumann, M.; Buchman, A. S.; Wang, Y.; Bennett, D. A.; Glass, J. D. G. D.; Trautwig, A. N.; Seyfried, N.; Cooper-Knock, J.; Hornstein, E.
10.1101/2025.04.20.648873 — neuroscience — Posted on 2025-04-24
1200 Lipid Mediated Formation of Antiparallel Aggregates in Cerebral Amyloid Angiopathy
Pacheco de Oliveira, A.; Baghel, D.; Holcombe, B.; Chase, W. E.; Ward, T.; Wang, S.-H. J.; Ghosh, A.
10.1101/2025.04.21.649887 — neuroscience — Posted on 2025-04-24
1202 Evidence of elemental encoding at the olfactory periphery
Raps, D. A.; Pierce, G. M.; Papiani, G.; Wu, L.; Arroyave, R.; Brann, J. H.; Pfister, P.
10.1101/2025.04.21.649882 — neuroscience — Posted on 2025-04-24
1203 Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations
Ambaw, Y. A.; Ljubenkov, P. A.; Singh, S.; Hamed, A.; Boland, S.; Boxer, A. L.; Walther, T. C.; Farese, R.
10.1101/2025.04.20.649464 — systems biology — Posted on 2025-04-24
1205 Convergence and constraint in glucosinolate evolution across the Brassicaceae
Agosto Ramos, A.; Bird, K.; Jain, A.; Okegbe, O.; Holland, L.; Kliebenstein, D. J.
10.1101/2025.04.23.650103 — plant biology — Posted on 2025-04-24
1207 High resolution diel transcriptomes of autotetraploid potato reveal expression and sequence conservation among rhythmic genes
Feke, A.; Vaillancourt, B.; Acheson, K.; Brose, J.; Hamilton, J. P.; Martin, D.; Wang, Y.-W.; Wood, J. C.; Buell, C. R.; Farre, E. M.
10.1101/2025.04.22.650056 — plant biology — Posted on 2025-04-24
1209 An approach to enhance symbiotic nitrogen fixation
Gavrin, A.; Batista, M. B.; Evangelisti, E.; Dixon, R.; Schornack, S.
10.1101/2025.04.23.649995 — plant biology — Posted on 2025-04-24
1210 Prevention and reversal of hypertension-induced coronary microvascular dysfunction by a plant-based diet
Najjar, R. S.; Hekmatyar, K.; Wang, Y.; Ngo, V. L.; Lail, H.; Tejada, J. P.; Danh, J. P.; Wanders, D.; Feresin, R. G.; Mehta, P. K.; Gewirtz, A.
10.1101/2025.04.19.649660 — physiology — Posted on 2025-04-24
1212 Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis
Freundt, J. K.; Hartmann, P.; Loescher, C. M.; Unger, A.; Koser, F.; Klotz, A. J.; Wachsmuth, L.; Hille, S.; Door, M. M.; Helfen, A.; Holtmeier, R.; Faber, C.; Kirk, J. A.; Hoerr, V.; Mueller, O. J.; Linke, W. A.
10.1101/2025.04.21.649485 — physiology — Posted on 2025-04-24
1213 Peptide-functionalized fluorescent polymeric nanoparticles: polysarcosine length defines stealth properties
Gupta, T.; Bui, Q. A.; Manirakiza, H.; El Hajji, L.; Humbert, N.; Mouhamad, A. W.; Reisch, A.; Gautier, A.; Klymchenko, A. S.
10.1101/2025.04.20.649688 — pharmacology and toxicology — Posted on 2025-04-24
1218 Label-Free Live-Cell Imaging improves Mode of Action Classification
Forsgren, E.; Rietdijk, J.; Holmberg, D.; Johansson, M. M.; Carreras-Puigvert, J.; Trygg, J.; Lovell, G.; Spjuth, O.; Jonsson, P.
10.1101/2025.04.22.649936 — bioinformatics — Posted on 2025-04-24
1219 TARRAGON: Therapeutic Target Applicability Ranking and Retrieval-Augmented Generation Over Networks
Beasley, J.-M.; Schatz, K.; Ding, E.; DeLuca, M.; Abu Zaid, N.; Tucker, N.; Chirkova, R.; Crona, D.; Tropsha, A.; Muratov, E.
10.1101/2025.04.19.649662 — bioinformatics — Posted on 2025-04-24
1221 Domoic acid biosynthesis and genome expansion in Nitzschia navis-varingica
Wood-Rocca, S. M.; Allsing, N.; Ashida, Y.; Mochizuki, M.; Moore, M. L.; Füssy, Z.; Kotaki, Y.; Puilingi, C.; Maeno, Y.; Beattie, A. W.; Allen, A. E.; Yotsu-Yamashita, M.; Michael, T. P.; Moore, B. S.
10.1101/2025.04.19.649686 — genomics — Posted on 2025-04-24
1222 High-density genome-wide association study points out major candidate genes for resistance to infectious pancreatic necrosis in rainbow trout
D'Ambrosio, J.; Francois, Y.; Morin, T.; Courant, S.; Desgranges, A.; Haffray, P.; Collet, B.; Boudinot, P.; Phocas, F.
10.1101/2025.04.19.649654 — genetics — Posted on 2025-04-24
1223 Local trade-offs shape flower size evolution across Arabidopsis thaliana distribution.
Sartori, K. F.; Fernandez Mestre, C.; Hossain, M. J.; Estarague, A. F.; Gaignon, E.; Lasky, J. R.; Vile, D.; Vasseur, F.; Violle, C.; Sicard, A.
10.1101/2025.04.19.649637 — evolutionary biology — Posted on 2025-04-24
1225 A pre-loaded and assembled human Ago2-miRISC orchestrates Shigella-induced vacuolar rupture through the targeting of RhoGDIα
Navarro, L.; Schiavolin, L.; Filopon, D.; Bonnet, M.; Perez-Quintero, A. L.; Charvin, M.; Sperandio, B.; Sansonetti, P. J.; TRAN VAN NHIEU, G.
10.1101/2025.04.23.650266 — molecular biology — Posted on 2025-04-24
1226 Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD
Chan, M. M.; Daemen, S.; Beatty, W.; Byrnes, K.; Cho, K.; Ferguson, D.; Park, A. C.; Fu, C. F.; Guo, Z.; Feldstein, N.; Park, C.; Florczak, K. L.; He, L.; Yang, B. Q.; Javaheri, A.; Patti, G.; Finck, B.; Razani, B.; Schilling, J. D.
10.1101/2025.04.19.649650 — immunology — Posted on 2025-04-24
1227 IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastoma
Barragan, G. A.; de la Cerda, D. A.; Landoni, E.; Dholakia, K.; Humeniuk, P.; Caraballo, L. D.; Wang, Y.; Tian, G.; Yang, B.; Guo, L.; Wood, M.; Rios, X.; Xu, X.; Courtney, A. N.; Dotti, G.; Metelitsa, L. S.
10.1101/2025.04.18.649551 — immunology — Posted on 2025-04-24
1230 Sleep firing rate homeostasis is disrupted in mild parkinsonism
Nandakumar, B.; Verma, A. K.; Yu, Y.; Marshall, E.; DeNicola, A.; Wang, J.; MacKinnon, C. D.; Howell, M. J.; Vitek, J. L.; Johnson, L. A.
10.1101/2025.04.18.649592 — neuroscience — Posted on 2025-04-24
1231 Hierarchical whole-brain modeling of critical synchronization dynamics in human brain
Myrov, V.; Suleimanova, A.; Knapic, S.; Liu, W.; Partanen, P.; Vesterinen, M.; Palva, S.; Palva, J. M.
10.1101/2024.05.08.593146 — neuroscience — Posted on 2025-04-24
1232 Designing Novel Solenoid Proteins with In Silico Evolution
Pretorius, D.; Nikov, G. I.; Washio, K.; Florent, S.-W.; Taunt, H.; Ovchinnikov, S.; Murray, J. W.
10.1101/2025.04.23.646631 — synthetic biology — Posted on 2025-04-24
1233 An ERF transcription factor StPTI5, a novel regulator of endophyte community maintenance in potato
Lukan, T.; Kraigher, B.; Pogacar, K.; Stare, K.; Grubar Kovacic, T.; Zagorscak, M.; Petek, M.; Stefanic, P.; Vozelj, A.; Levak, V.; Mahkovec Povalej, T.; Garcia, J. M.; Pozo, M. J.; Mandic-Mulec, I.; Gruden, K.
10.1101/2025.04.24.650297 — plant biology — Posted on 2025-04-24
1235 Pseudomonas syringae pv. tomato and the fall armyworm modulate the morpho-physiology and the metabolome of potato plants
Maluleke, S.; Ogugua, U. V.; Madala, N. E.; Sibisi, P.; Mazibuko, M. P.; Nofemela, S. R.; Udeh, E. L.; Ntushelo, K.
10.1101/2025.04.23.650202 — plant biology — Posted on 2025-04-24
1239 Single cell omics extends metabolic regulon via orthologous transcription factors from a pair of medicinal plant species
Bui, V.-H.; Wood, J. C.; Vaillancourt, B.; Hamilton, J. P.; Jones, S. L.; Carlton, L. H.; Vu, A. H.; Buell, C. R.; Caputi, L.; Dang, T.-T. T.; Li, C.
10.1101/2025.04.22.650021 — plant biology — Posted on 2025-04-24
1241 Deciphering the Sequence Basis and Application of Transcriptional Initiation Regulation in Plant Genomes Through Deep Learning
Gao, P.; Lian, L.; Feng, W.; Ma, Y.; Lin, J.; Qin, L.; Hao, S.; Zhao, H.; Liu, X.; Yuan, J.; Lin, Z.; Li, X.; Guan, Y.; Wang, X.
10.1101/2025.04.22.649999 — plant biology — Posted on 2025-04-24
1243 A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics
Leconte, G.; Gadbois, G. E.; Sepulveda, Y.; Schwarz, A.; Chang, E.; Suhandynata, R. T.; Momper, J. D.; Ferguson, F.
10.1101/2025.04.18.649560 — pharmacology and toxicology — Posted on 2025-04-24
1244 Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking
Wittling, M. C.; Rivera Reyes, A. M.; Wyatt, M. M.; Smith, A. S.; Cole, A. C.; Rangel Rivera, G. O.; Ware, M. B.; Ruffin, A. T.; Kumaresan, S.; Bennett, F. J.; Lesinski, G. B.; Paulos, C. M.; Knochelmann, H. M.
10.1101/2025.04.18.649565 — cancer biology — Posted on 2025-04-24
1245 ZMS-6659, a selective Polθ helicase inhibitor, demonstrates anti-tumor activity as monotherapy and synergy effect with PARP inhibitors and topoisomerase inhibitors
jiang, l.; Li, J.; Liu, L.; Li, M.; Li, W.; Li, Z.; Qian, S.; Shi, M.; Dai, J.; Ao, C.; Qu, Y.; Li, Z.; Zhou, L.; Yang, C.; Wang, X.; Tang, R.; Zhou, F.; Liu, G.; Xue, L.
10.1101/2025.04.19.649634 — cancer biology — Posted on 2025-04-24
1247 One-Hot News: Drug Synergy Models Take a Shortcut
Candir, E. B.; Kuru, H. I.; Rattray, M.; Cicek, A. E.; Tastan, O.
10.1101/2025.04.18.649584 — bioinformatics — Posted on 2025-04-24
1249 Characterization of active kinase signaling pathways in astrocytes and microglia
Ryan, W. G.; Eby, H. M.; Bearss, N. R.; Imami, A. S.; Hamoud, A.-r.; Pulvender, P.; Bollinger, J. L.; Wohleb, E. S.; McCullumsmith, R. E.
10.1101/2025.04.18.649617 — bioinformatics — Posted on 2025-04-24
1251 Neophilia in wolves and dogs
Rivas-Blanco, D.; Gonnet-dit-Revel, L.; Range, F.; Tebbich, S.; Marshall-Pescini, S.
10.1101/2025.04.24.650376 — animal behavior and cognition — Posted on 2025-04-24
1253 Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains captures global and local expression variation
Rebboah, E.; Weber, R.; Abdollahzadeh, E.; Swarna, N. P.; Sullivan, D. K.; Trout, D.; Reese, F.; Liang, H. Y.; Filimban, G.; Mahdipour, P.; Duffield, M.; Mojaverzargar, R.; Taghizadeh, E.; Fattahi, N.; Mojgani, N.; Zhang, H.; Loving, R. K.; Carilli, M.; Booeshaghi, A. S.; Kawauchi, S.; Hallgrimsdottir, I. B.; Williams, B. A.; MacGregor, G.; Pachter, L.; Wold, B.; Mortazavi, A.
10.1101/2025.04.21.649844 — genomics — Posted on 2025-04-24
1254 Identifiability of Phylogenetic Level-2 Networks under the Jukes-Cantor Model
Englander, A. K.; Frohn, M.; Gross, E.; Holtgrefe, N.; van Iersel, L.; Jones, M.; Sullivant, S.
10.1101/2025.04.18.649493 — evolutionary biology — Posted on 2025-04-24
1257 Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity
Deyab, G.; Thomas, R. A.; Ding, X. E.; Li, J.; Sirois, J.; Al Azzawi, Z.; Niu, S.; Durcan, T.; Fon, E. A.
10.1101/2025.04.23.650231 — neuroscience — Posted on 2025-04-24
1259 Iron deposition and functional connectivity alterations in the right substantia nigra of adult males with autism
Itahashi, T.; Tanji, K.; Shikauchi, Y.; Naoe, T.; Okimura, T.; Nakamura, M.; Ohta, H.; Hashimoto, R.-i.
10.1101/2025.04.18.649491 — neuroscience — Posted on 2025-04-24
1260 Neuronal Hyperexcitability: A Key to Unravelling Hippocampal Synaptic Dysfunctions in Lafora Disease
Costa, C.; Bellingacci, L.; Canonichesi, J.; Imperatore, V.; Taddei, A. A.; Zafra-Puerta, L.; Iglesias-Cabeza, N.; Prontera, P.; Mancini, A.; Di Filippo, M.; Tozzi, A.; Barzasi, M.; Gardoni, F.; Sanchez, M. P.; Serratosa, J. M.; Parnetti, L.; Sciaccaluga, M.
10.1101/2025.04.23.650182 — neuroscience — Posted on 2025-04-24
1261 Cognitive Graphs of Latent Structure in Rostral Anterior Cingulate Cortex
Manakov, M.; Proskurin, M.; Wang, H.; Kuleshova, E.; Lustig, A.; Behnam, R.; Druckmann, S.; Tervo, D. G. R.; Karpova, A.
10.1101/2025.04.18.649507 — neuroscience — Posted on 2025-04-24
1262 Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells
Vrynas, A.; Bazban-Shotorbani, S.; Arfan, S.; Satia, K.; Cunningham, B.; Sagindykova, G.; Ashna, M.; Zhang, A.; Visan, D.; Chen, A.; Carter, M.; Matthews-Palmer, T.; Blackhall, F.; Simpson, K.; Dive, C.; Huang, P. H.; Au, S. H.
10.1101/2024.04.17.589880 — cancer biology — Posted on 2025-04-24
1263 Refining sperm quality assessment by high-throughput nuclear morphometric analysis
Mandawala, A. A.; Perry, J. C.; Skinner, B. M.; Walling, G. A.; Harvey, S. C.; Harvey, K. E.
10.1101/314708 — developmental biology — Posted on 2025-04-24
1265 Evolutionary dynamics of FoxQ2 transcription factors across metazoans: A tale of three ancient paralogs
Gattoni, G.; Lin, C.-Y.; York, J. R.; Keitley, D.; LaBonne, C.; Yu, J.-K.; Gillis, A.; Benito-Gutierrez, E.
10.1101/2025.04.23.650082 — evolutionary biology — Posted on 2025-04-24
1267 DAR1: A Flexible Framework for Ecosystem Model Exploration
Duckworth, B.; Dutkiewicz, S.; Jahn, O.; Hill, C. N.; Follett, C. L.
10.1101/2023.11.23.568480 — ecology — Posted on 2025-04-24
1268 Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish
Sengul, E.; Potts, H. G.; Stockdale, W. T.; Carter, R. D.; Bevan, L.; Nozdrina, M.; Alonaizan, R.; Hu, Z.; Goodship, A.; Ying, J.; Lekkos, K.; O Byrne, L.; Lemieux, M. E.; Richardson, R.; Mommersteeg, M. T. M.
10.1101/2025.04.24.650152 — developmental biology — Posted on 2025-04-24
1269 Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal extensive post-translational modifications.
Müller, M.-C.; Wissink, M.; Mukherjee, P.; Von Possel, N.; Laso-Perez, R.; Engilberge, S.; Carpentier, P.; Kahnt, J.; Wegener, G.; Welte, C.; Wagner, T.
10.1101/2025.01.10.632498 — microbiology — Posted on 2025-04-24
1274 Evaluating a Standard Benchmark for Gene Prioritization: The InheriNext(R) Algorithm's Integration of Genomic and Phenotypic Information
Chang, J.-Y.; Li, K.-T.; Kubal, M.; Tsai, Y.-S.; Hamby, A. M.; Thomson, N.; Sheridan, J.; Barfield, S.; Rutz, R.; Ong, F. S.; Feliciano, R.; Kahn, S.; Wu, S.-M.
10.1101/2025.02.25.640147 — genomics — Posted on 2025-04-24
1276 GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research
Ingle, O. K.; Melville, L.; Beechener, S.; Hardy, C.; Howell, A.; Hobbs, N. P.; Mahon, N.; Morgan, E. R.; Bartley, D.; Rose Vineer, H.
10.1101/2025.02.21.639461 — ecology — Posted on 2025-04-24
1278 Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Shayler, D. W. H.; Stachelek, K.; Cambier, L.; Lee, S.; Bai, J.; Bhat, B.; Reid, M. W.; Weisenberger, D. J.; Aparicio, J. G.; Kim, Y.; Singh, M.; Bay, M.; Thornton, M. E.; Doyle, E. K.; Fouladian, Z.; Erberich, S. G.; Grubbs, B. H.; Bonaguidi, M. A.; Craft, C. M.; Singh, H. P.; Cobrinik, D.
10.1101/2023.02.28.530247 — developmental biology — Posted on 2025-04-24
1279 Mesenchymal Stromal Cells regulate human Hematopoietic Stem Cell survival, engraftment and regeneration via PGE2/cAMP signaling pathway
MUDDINENI, S. S. N. A.; Katz-Even, C.; Zipin-Roitman, A.; Rasoulouniriana, D.; Roy, D. S.; Aborgies, R.; Weizman, E.; Beider, K.; Chen, R.; Hershkovitz, G.; Shulman, Y.; Solomon, N.; Raz, Y.; Waskow, C.; Nagler, A.; Milyavsky, M.
10.1101/2023.11.09.566361 — cell biology — Posted on 2025-04-24
1280 Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer
Haas, A.; Wenz, F.; Wesslowski, J.; Davidson, G.; Voloshanenko, O.; Boutros, M.; Perez Acebron, S.; Bastians, H.
10.1101/2025.04.23.650265 — cell biology — Posted on 2025-04-24
1282 Aspergillus dsRNA virus drives fungal fitness and pathogenicity in the mammalian host
Rocha, M.; Lerer, V.; Adeoye, J.; Hayby, H.; Fabre, M. L.; Barber, A. E.; Shlezinger, N.
10.1101/2024.02.16.580674 — microbiology — Posted on 2025-04-24
1286 Establishing synthetic ribbon-type active zones in a heterologous expression system
Kapoor, R.; Do, T. T.; Schwenzer, N.; Petrovic, A.; Dresbach, T.; Lehnart, S.; Fernandez-Busnadiego, R.; Moser, T.
10.1101/2024.03.18.585517 — neuroscience — Posted on 2025-04-24
1287 Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia
Sneha, R. B.; Brundu, F.; Chen, Y.; Sun, Y.; Zhu, H.; Shprintzen, R. J.; Tomer, R.; Rabadan, R.; Leong, K. W.; Markx, S.; Xu, B.; Gogos, J. A.; Kushner, S. A.
10.1101/2023.10.04.557612 — neuroscience — Posted on 2025-04-24
1288 Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease
Xiao, Y.; Spotorno, N.; An, L.; Bazinet, V.; Hansen, J. Y.; Strandberg, O.; Shafiei, G.; Bejhat, H. H.; Funck, T.; Salvado, G.; Stomrud, E.; Smith, R.; Palmqvist, S.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Palomero-Gallagher, N.; Dagher, A.; Misic, B.; Hansson, O.; Vogel, J. W.
10.1101/2025.04.17.648358 — neuroscience — Posted on 2025-04-24
1289 Stimulus-specificity of surround-induced responses in primary visual cortex
Cuevas, N.; Sotomayor-Gomez, B.; Tzanou, A.; Onorato, I.; Rummell, B.; Uran, C.; Broggini, A.; Vinck, M.
10.1101/2024.06.03.597080 — neuroscience — Posted on 2025-04-24
1294 The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress
Huang, Q.; Monzel, A. S.; Rausser, S.; Haahr, R.; Bobba-Alves, N.; Devine, J.; Liu, C. C.; Kelly, C.; Thompson, E.; Kurade, M. S.; Michelson, J.; Li, S.; Engelstad, K.; Tanji, K.; Lauriola, V.; Wang, T.; Wang, S.; Marsland, A. L.; Kaufman, B. A.; St-Onge, M.-P.; Sloan, R.; Juster, R.-P.; Gouspillou, G.; Hirano, M.; Picard, M.; Trumpff, C.
10.1101/2024.04.19.590241 — physiology — Posted on 2025-04-24
1297 Biophysics-based protein language models for protein engineering
Gelman, S.; Johnson, B.; Freschlin, C.; Sharma, A.; D'Costa, S.; Peters, J.; Gitter, A.; Romero, P. A.
10.1101/2024.03.15.585128 — bioinformatics — Posted on 2025-04-24
1299 Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition
Cotet, T.-S.; Krawczuk, I.; Stocco, F.; Ferruz, N.; Gitter, A.; Kurumida, Y.; Machado, L. d. A.; Paesani, F.; Calia, C. N.; Challacombe, C. A.; Haas, N.; Qamar, A.; Correia, B. E.; Pacesa, M.; Nickel, L.; Subr, K.; Castorina, L. V.; Campbell, M. J.; Ferragu, C.; Kidger, P.; Hallee, L.; Wood, C. W.; Stam, M. J.; Kluonis, T.; Unal, S. M.; Belot, E.; Naka, A.; Adaptyv Competition Organizers,
10.1101/2025.04.17.648362 — bioengineering — Posted on 2025-04-24
1301 Detection of bacteria through taste receptors primes the cellular immune response
Mazariegos, A. N.; Maniere, G.; Sillon, L.; Milleville, R.; Berthelot-Grosjean, M.; Aruci, E.; Camp, D.; Alves, G.; Khaul, R.; Duval, C. J.; Chauvel, I.; Royet, J.; Grosjean, Y.; Musso, P.-y.; Tanentzapf, G.
10.1101/2024.09.26.615243 — immunology — Posted on 2025-04-24
1303 Individual differences in sequential decision-making
Abbaszadeh, M.; Ozanick, E.; Magen, N.; Darrow, D. P.; Yan, X.; Grissom, N.; Herman, A.; Ebitz, B.
10.1101/2025.04.04.647306 — neuroscience — Posted on 2025-04-24
1304 Sialoglycoconjugate Profiling of Human Choroid, Retinal Pigment Epithelium, and Macular Degeneration Related Lesions
Navratil, E. M.; Wenzel, P. A.; Flamme-Wiese, M. J.; Miller, J. E. B.; Wiley, L. A.; Stone, E. M.; Tucker, B. A.; Mullins, R. F.
10.1101/2025.04.23.650306 — cell biology — Posted on 2025-04-23
1308 Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Carloni, R.; Devlin, T.; Tong, P.; Auchynnikava, T.; Spanos, C. R.; Rappsilber, J.; Matthews, K. R.; Allshire, R. C.
10.1101/2025.04.22.649942 — cell biology — Posted on 2025-04-23
1309 The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival.
Spangenberg, S. H.; Garaffo, N.; Alcindor, E. M. C.; Lusk, B.; Pandey, V.; Longhurst, A.; Bolech, E.; Fu, B. X. H.; Gilbert, L. A.; Wohlschlegel, J. A.; Toczyski, D. P.
10.1101/2025.04.22.649889 — cell biology — Posted on 2025-04-23
1310 Hierarchical cross-entropy loss improves atlas-scale single-cell annotation models
Cultrera di Montesano, S.; D'Ascenzo, D.; Raghavan, S.; Amini, A. P.; Winter, P.; Crawford, L.
10.1101/2025.04.23.650210 — cell biology — Posted on 2025-04-23
1311 A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets
Fye, M. A.; Sharma, R.; Myat, P. S. M.; Regan, P.; McKinney, H.; Gu, G.; Kaverina, I.
10.1101/2025.04.22.650066 — cell biology — Posted on 2025-04-23
1313 Curvature-dependent morphological reorganization of the endoplasmic reticulum determines the mode of epithelial migration
Rawal, S.; Keshavanarayana, P.; Manoj, D.; Khuntia, P.; Banerjee, S.; Thurakkal, B.; Marwaha, R.; Spill, F.; Das, T.
10.1101/2025.04.22.650137 — cell biology — Posted on 2025-04-23
1317 Oncogenic mutations disrupt lineage differentiation via epigenetic perturbations
Meng, L.; Plevritis, S. K.; Yu, A.; Meng, J.; Yoo, Y.; Janas, J.; Knowles, D. A.; Huang, H.; Schaukowitch, K. M.
10.1101/2025.04.22.649974 — cell biology — Posted on 2025-04-23
1318 Stress tolerance of multiple Salmonella enterica strains associated with foodborne outbreaks
Martin, A.; Patch, C.; Vanarsdall, V. A.; Pham, R.; Whitney, G.; Markus, S.; Lunna, A.; Etter, A. J.
10.1101/2025.04.23.649775 — microbiology — Posted on 2025-04-24
1319 Tsbrowse: an interactive browser for Ancestral Recombination Graphs
Karthikeyan, S.; Jeffery, B.; Mbuli-Robertson, D.; Kelleher, J.
10.1101/2025.04.23.649987 — genomics — Posted on 2025-04-23
1322 Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer
Bastians, H.; Haas, A.; Wenz, F.; Wesslowski, J.; Davidson, G.; Voloshanenko, O.; Boutros, M.; Perez Acebron, S.
10.1101/2025.04.23.650265 — cell biology — Posted on 2025-04-23
1323 An evolutionarily conserved laterally acquired toolkit enables microbiota targeting by Trichomonas
Hart, A. J.; Mpeyako, L.; Bailey, N. P.; Merces, G.; Gray, J.; Biboy, J.; Banzhaf, M.; Vollmer, W.; Hirt, R. P.
10.1101/2025.04.21.649813 — molecular biology — Posted on 2025-04-23
1324 The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection
Desgraupes, S.; Perrin, S.; Gouy, B.; Decorsiere, A.; Wang, Y. E.; Palazzo, A. F.; Munier, S.; Arhel, N. J.
10.1101/2025.03.23.644734 — immunology — Posted on 2025-04-23
1326 Neuroanatomy Reflects Individual Variability In Impulsivity in Youth
Dhamala, E.; Christensen, E.; Hanson, J. L.; Ricard, J. A.; Arcaro, N.; Bhola, S.; Wiersch, L.; Brosch, K.; Yeo, B. T. T.; Holmes, A.; Yip, S.
10.1101/2025.04.23.650222 — neuroscience — Posted on 2025-04-23
1328 PACS1 syndrome variant alters proteomic landscape of developing cortical organoids
Gomez Maqueo Bribiesca, X.; Rylaarsdam, L.; Woo, A.; Schroder, A. L.; Rakotomamonjy, J.; Ruiz, S.; Gilardi, J.; Klei, L.; Devlin, B.; MacDonald, M. L.; Guemez-Gamboa, A.
10.1101/2025.04.23.650290 — neuroscience — Posted on 2025-04-23
1332 Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation
Honkura, Y.; Suzuki, T.; Kujirai, R.; Kanno, S.; Matsumoto, Y.; Tanaka, Y.; Kowit, H.; Nagatoishi, S.; Tyshkovskiy, A.; Kasahara, T.; Tongu, Y.; Bohan, Z.; Kashiwagi, H.; Saegusa, C.; Fujioka, M.; Usami, R.; Chikuma, S.; Tokifuji, Y.; Matsuhashi, T.; Oikawa, Y.; Komatsu, H.; Murayama, K.; Sugasawa, T.; Nanto-Hara, F.; Taguchi, K.; Saigusa, D.; Suzuki, C.; Sato, T.; Suzuki, J.; Owada, Y.; Niizuma, K.; Endo, H.; Hashimoto, K.; Toyohara, T.; Tsumoto, K.; Anderson, P.; Gladyshev, V. N.; Hayashi, K.-i.; Katori, Y.; Tomioka, Y.; Abe, T.
10.1101/2025.04.18.649305 — cell biology — Posted on 2025-04-23
1334 Investigating Factors Driving Shifts in Subtype Dominance within H5Nx Clade 2.3.4.4b High-Pathogenicity Avian Influenza viruses
Billington, E.; Di Genova, C.; Warren, C. J.; Thomas, S. S.; Johnson, S.; Riccio, S.; Temperton, N. J.; da Costa, K.; Byrne, A. M. P.; Airey, M.; Schlachter, A.-L.; Yang, J.; Nunez, A.; Iqbal, M.; Slomka, M. J.; Brown, I. H.; Banyard, A. C.; James, J.
10.1101/2025.04.23.650244 — microbiology — Posted on 2025-04-23
1335 STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity
Girard, M.; Yu, T.; Batista, N. V.; Yeung, K. K.; Lamorte, S.; Gao, W.; Liu, M.; McGaha, T. L.; Watts, T. H.
10.1101/2024.12.08.627385 — immunology — Posted on 2025-04-23
1336 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb
Klimpert, N.; Kollo, M.; Brann, D. H.; Tan, C.; Barry, D.; Ma, Y.; Schaefer, A. T.; Fleischmann, A.
10.1101/2025.02.19.639192 — neuroscience — Posted on 2025-04-23
1337 Cell cycle follows pause and play mechanism in environment stress recovery in diverse plant species
Hazelwood, O. S.; Diehl, K. A.; Hollenbeck, V.; Herb, D.; Gallagher, J. P.; Ashraf, A.
10.1101/2025.04.02.646900 — plant biology — Posted on 2025-04-23
1338 Drosophila SA1 expression prevents brain tumorigenesis and PARP-mediated cell elimination
Totaro, S.; Lettieri, A.; Castiglioni, S.; Lavezzari, F.; Gervasini, C.; Massa, V.; vaccari, t.
10.1101/2025.04.18.649500 — cancer biology — Posted on 2025-04-23
1339 Learning tissue representation by identification of persistent local patterns in spatial omics data
Tanevski, J.; Vulliard, L.; Ibarra-Arrelano, M. A.; Schapiro, D.; Hartmann, F.; Saez-Rodriguez, J.
10.1101/2024.03.06.583691 — bioinformatics — Posted on 2025-04-23
1341 CRISPR/Cas9-mediated mutagenesis of the white-eye gene in the tephritid pest Bactrocera zonata
Nazarov, A.; Partosh, T.; krsticevic, f.; Rallis, D.; arien, y.; Ostrovsky, G.; Kramer, R. M.; Halon, E.; Handler, A.; Baxter, S.; Gazit, Y.; Mathiopoulos, K.; Pines, G.; Papathanos, P. A.
10.1101/2025.04.22.650062 — bioengineering — Posted on 2025-04-23
1342 HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
Ikeda, T.; Hong, S.; Yoshida, S.; Kunamneni, A.; Srivastava, S. P.; Yao, Y.; Basrur, V.; Kuang, H.; Kachman, M.; Baum, H.; Joshi, A.; Swaroop, V.; Thurman, A.; Kopasz-Gemmen, O.; Kandukuri, S.; Khuperkar, O.; Pradeepa, F.; Yonekura, H.; Lin, J. D.; Inoki, K.
10.1101/2025.04.22.650033 — biochemistry — Posted on 2025-04-23
1343 Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish
Ono, Y.; Peterka, M.; Love, M.; Bhandari, A.; Gordon, E.; Ball, J. S.; Tyler, C. R.; Rees, S.; Bohlooly-Y, M.; Maresca, M.; Scholpp, S.
10.1101/2025.04.23.650248 — molecular biology — Posted on 2025-04-23
1344 How does Mycoplasma pneumoniae steal lipids from its host membranes?
Manger, S.; Arghittu, S. M.; Sprankel, L.; Meier-Credo, J.; Wieland, K.; Bublak, D.; Langer, J.; Covino, R.; Frangakis, A. S.
10.1101/2023.10.24.563710 — molecular biology — Posted on 2025-04-23
1345 United States PRRSV 1-4-4 L1C.5 isolate demonstrates similar pathogenicity to a historic Chinese highly pathogenic PRRSV
Wiarda, J. E.; Anderson, S. J.; Kim, H.; Chang, T.; Tidgren Hanson, L.; Zanella, E. L.; Arruda, B.; Wymore Brand, M.; Hau, S. J.; Zhang, J.; Buckley, A. C.
10.1101/2025.04.23.648216 — microbiology — Posted on 2025-04-23
1347 A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals the role of GDV1 in ap2-g activation.
Prajapati, S. K.; Dong, J. X.; Morahan, B. J.; Dotrang, T.; Barbeau, M. C.; Williams, A. E.; Hupalo, D.; Wilkerson, M. D.; Dalgard, C. L.; Kafsack, B. F. C.; Llinas, M.; Williamson, K. C.
10.1101/2025.04.22.648970 — microbiology — Posted on 2025-04-23
1348 Dietary Protein Sources Shape Gut Microbiome: Insights from Meta-analysis and Machine Learning
ADEJUMO, S. A.; Das, P.; Ghimire, S.; Kin Yun Lim, C.; Malas, J.; Allen, J.; Hampton-Marcell, J. A.
10.1101/2025.04.23.650130 — microbiology — Posted on 2025-04-23
1349 Quantitative insights into the efficacy of genome-resolved surveys of microbial communities through ribosomal protein phylogeography and EcoPhylo
Schechter, M. S.; Trigodet, F.; Veseli, I. A.; Miller, S. E.; Klein, M. L.; Sever, M.; Maignien, L.; Delmont, T. O.; Light, S. H.; Eren, A. M.
10.1101/2025.01.15.633187 — microbiology — Posted on 2025-04-23
1350 The effect of different milk pretreatment methods on microbiome community development during Herrgards cheese production and ripening.
Rodriguez, J. A.; Santos-Bay, L.; Narechania, A.; Caroe, C.; Siren, K.; Mak, S. S. T.; Broman Nielsen, I.; Ramsoe, M.; Ponten, T. S.; Lillevang, S.; Tranberg Andersen, L.; Gilbert, M. T. P.
10.1101/2025.04.23.648337 — microbiology — Posted on 2025-04-23
1352 Antigen avidity drives the durability of the vaccine immune response.
Weidner, N. G.; Padilla, M. V.; Pruitt, L.; Cottrell, C. A.; Gonzales, K.; Kalyuzhniy, O.; Kubitz, M.; Alavi, N.; Phelps, N.; Weglarz, M.; Schief, W. R.; Abbott, R. K.
10.1101/2025.04.18.649567 — immunology — Posted on 2025-04-23
1353 A temporally restricted function of the Dopamine receptor Dop1R2 during memory formation
Kaldun, J. C.; Calia, E.; Bangalore Mukunda, G. C.; Fritsch, C.; Komarov, N.; Sprecher, S. G.
10.1101/2024.05.29.594954 — neuroscience — Posted on 2025-04-23
1356 The structure, folding kinetics and dynamics of long poly(UG) RNA
Petersen, R. J.; Vivek, R.; Tonelli, M.; Roschdi, S.; Butcher, S. E.
10.1101/2025.04.22.650042 — biochemistry — Posted on 2025-04-23
1358 Septin7 is essential in early hematopoiesis, but redundant at later stages
Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.
10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-04-23
1359 Ecologically Significant Genetic Loci of P. allii: Contributions to Pathogenesis and Competition
Shin, G. Y.; De Armas, S.; Galvan, G. A.; Siri, M. I.; vinatzer, B. A.; Asselin, J. A. E.; Stodghill, P.; Zhao, M.; Dutta, B.; Tambong, J.; Kvitko, B. H.
10.1101/2025.04.23.650278 — genomics — Posted on 2025-04-23
1360 Aviadenovirus structure: a highly thermostable capsid in the absence of stabilizing proteins
Perez-Illana, M.; Schachner, A.; Hernando-Perez, M.; Condezo, G.; Paradela, A.; Martinez, M.; Marabini, R.; Hess, M.; San Martin, C.
10.1101/2025.04.23.650237 — molecular biology — Posted on 2025-04-23
1361 MotorBench: A Cryo-Electron Tomography Dataset of Bacterial Flagellar Motors for Testing Detection Algorithms
Owens, C. B.; Morse, B. S.; Darley, A. J.; Hart, T. J.; Webb, R.; Maggi, S.; Jensen, G. J.; Ward, M. M.; Reade, W. C.; Kaplan, M.; Hart, G. L. W.
10.1101/2025.04.23.650258 — molecular biology — Posted on 2025-04-23
1362 Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure
Gordillo Altamirano, F. L.; Subedi, D.; Beiers, M.; Bucher, M. J.; Dahlman, S.; Patel, D. M.; Parker, M.; Korneev, D.; Pragastis, K.; Wisniewski, J.; Rees, C.; Ramshaw, H.; Khan, S.; Gardiner, B.; Hammerschlag, Y.; Keating, D.; Kotsimbos, T.; Hawkey, J.; Barr, J. J.; Peleg, A. Y.
10.1101/2025.04.22.650118 — microbiology — Posted on 2025-04-23
1367 Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome Studies
Hitch, T. C. A.; Bosch, J.; Bolsega, S.; Deschamps, C.; Etienne-Mesmin, L.; Treichel, N. S.; Blanquet-Diot, S.; Ocvirk, S.; Basic, M.; Clavel, T.
10.1101/2025.04.23.650235 — microbiology — Posted on 2025-04-23
1371 Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia in vitro models
Marku, M.; Chenel, H.; Bordenave, J.; Hurtado, M.; Domagala, M.; Raynal, F.; Poupot, M.; Ysebaert, L.; Zinovyev, A.; Pancaldi, V.
10.1101/2025.04.20.649300 — systems biology — Posted on 2025-04-23
1373 VasoTracker 2: An Open-source Platform for Quantitative Analysis of Vascular Reactivity and Function
Lee, M. D.; Osborne, C.; Stevenson, R.; MacDonald, A.; Ebner, G.; Jeffrey, D. A.; MacDonald, M. A.; Zhang, X.; Buckley, C.; Dabertrand, F.; Machin, D. R.; Au, J.; Harraz, O. F.; Tykocki, N.; McCarron, J. G.; Wilson, C.
10.1101/2025.04.23.648411 — physiology — Posted on 2025-04-23
1374 Enhanced efficacy of a specific HDAC3 inhibitor in combination with 5-Azacitidine against diffuse large B-cell lymphoma
Calaud, C.; Serrano-Lopez, E.; Cluse, L.; Todorovski, I.; Mardivirin, T.; Teater, M.; Maarad, A.; Tawfic, N.; Rutaquio, S.; Fraser, P. J.; Guiraud, K.; Yoannidis, D.; Kerreneur, E.; Jacquel, A.; Melnick, A. M.; Johnstone, R. W.; Dominguez, P. M.
10.1101/2025.04.21.648509 — cancer biology — Posted on 2025-04-23
1380 Chimeric Reference Panels for Genomic Imputation
Zhou, M.; James, M.; Engelstaedter, J.; Ortiz-Barrientos, D.
10.1101/2025.04.22.648973 — bioinformatics — Posted on 2025-04-23
1381 Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling
Bellofatto, K.; Lebreton, F.; Hassany, M.; Hanna, R.; Bignard, J.; Marteyn, A.; Mar Fonseca, L.; Campo, F.; Olgasi, C.; Wolf-van Buerck, L.; Honarpisheh, M.; MARTINEZ DE TEJADA WEBER, B.; Follenzi, A.; Citro, A.; Piemonti, L.; THAUNAT, O.; Seissler, J.; COMPAGNON, P.; cohen, m.; BERISHVILI, E.; VANGUARD consortium,
10.1101/2025.04.19.647461 — bioengineering — Posted on 2025-04-23
1382 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging
Amaral, M. L.; Mamde, S.; Miller, M.; Hou, X.; Arzavala, J.; Osteen, J.; Walker Smoot, E.; Yang, Q.; Eisner, E.; Zeng, Q.; Baez-Becerra, C. T.; Olness, J.; Kern, J. C.; Rink, J.; Johnson, N.; Barcoma, A.; Cho, S.; Cao, S.; Emerson, N.; Lee, J.; Willier, J.; Loe, T.; Jiao, H.; Zu, S.; Zhu, Q.; Preissl, S.; Wang, A.; Ecker, J.; Behrens, M. M.; Ren, B.
10.1101/2025.04.21.649585 — genomics — Posted on 2025-04-23
1383 Azurify integrates cancer genomics with machine learning to classify the clinical significance of somatic variants
Bigdeli, A.; Chandrashekar, D. S.; Chitturi, A.; Rushton, C.; Mackinnon, A. C.; Segal, J.; Harada, S.; Sacan, A.; Faryabi, R. B.
10.1101/2025.04.18.649588 — genomics — Posted on 2025-04-23
1384 Biodiversity temporal trends are reshaping food web structure and redundancy in riverine ecosystems
Danet, A.; El Madouri, L.; Bonnaffe, W.; Beckerman, A. P.; Mouchet, M.; Fontaine, C.; Thebault, E.
10.1101/2025.04.23.649202 — ecology — Posted on 2025-04-23
1386 Targeting RhoA activity rejuvenates aged hematopoietic stem cells
Mejia-Ramirez, E.; Ianez-Picazo, P.; Walter, B.; Montserrat-Vazquez, S.; Affuso, F.; Wieser, S.; Pezzano, F.; Reymond, L.; Castillo-Robles, J.; Matteini, F.; Mularoni, L.; Macia, D.; Raya, A.; Ruprecht, V.; Zheng, Y.; Petrone, P.; Florian, M. C.
10.1101/2025.04.23.647902 — cell biology — Posted on 2025-04-23
1387 Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins
Harris Snell, P. L.; Naeli, P.; Garzia, A.; Waldron, J. A.; Chatterjee, S.; McGirr, T.; Ladak, R. J.; Choi, J.-H.; Luo, J.; Leino, S.; Jess, N.; Shariati, A.; Soto Rodriguez, X.; Gkogkas, C. G.; Sonenberg, N.; Tuschl, T.; Maguire, S.; Jafarnejad, S. M.
10.1101/2025.04.21.649502 — cell biology — Posted on 2025-04-23
1388 Harnessing the Power of Single-Cell Large Language Models with Parameter Efficient Fine-Tuning using scPEFT
He, F.; Fei, R.; Krull, J. E.; Zhang, X.; Gao, M.; Su, L.; Chen, Y.; Yu, Y.; Li, J.; Jin, B.; Chang, Y.; Ma, A.; Ma, Q.; Xu, D.
10.1101/2025.04.21.649754 — cell biology — Posted on 2025-04-23
1391 A direct RNA-seq-based EBV Latency Transcriptome Offers Insights into the Biogenesis of EBV Gene Products.
Mamane-Logsdon, A.; Zane, I.; Chong, C. S.; Chou, O. H. I.; Rawal, M.; Gillman, A. C. T.; Wongwiwat, W.; Donovan-Banfield, I.; Matthews, D. A.; White, R. E.
10.1101/2025.04.23.648900 — microbiology — Posted on 2025-04-23
1392 Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia
Wu, F.; Moskovjlevic, M.; Dragoni, F.; Jayaraman, S.; Board, N. L.; Camilo-Contreras, A.; Bernal, S.; Hariharan, V.; Zhang, H.; Lai, J.; Singhal, A.; Poulin, S.; Chano, F.; Chamberland, A.; Tremblay, C.; Zoltik, M.; Hoffmann, C. J.; Jones, J. L.; Larman, H. B.; Montaner, L. J.; Siliciano, J. D.; Siliciano, R. F.; Simonetti, F. R.
10.1101/2025.04.19.649587 — immunology — Posted on 2025-04-23
1395 Short Report: A Meta-Analysis of the Effects of Sleep Deprivation on the Cortical Transcriptome in Animal Models
Rhoads, C. A.; Hagenauer, M. H.; Xiong, J.; Hernandez, E.; Nguyen, D. M.; Saffron, A.; Flandreau, E. I.; Watson, S.; Akil, H.
10.1101/2025.04.21.648791 — neuroscience — Posted on 2025-04-23
1399 Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive Disease
Prabhakar, A.; Kumar, R.; Wadhwa, M.; Barpanda, A.; Lyons, J.; Gowda, A.; Gupta, S.; Arvind, A.; Ghatpande, P.; Wiita, A.; Graham, B. B.; Lagna, G.; Hata, A.
10.1101/2025.04.18.649514 — cell biology — Posted on 2025-04-23
1400 Monitoring the poroelastic response of collagen gels with embedded senescent fibroblasts reveals tissue softening associated with collagen network reorganization
Cacheux, J.; Quenan, T.; Alcaide, D.; Ordonez-Miranda, J.; Jalabert, L.; Nakano, S.; Nakanishi, M.; Cordelier, P.; Bancaud, A.; Matsunaga, Y. T.
10.1101/2025.04.18.649513 — biophysics — Posted on 2025-04-23
1401 Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease
D'Addario, S. L.; Massaro Cenere, M.; Cossa, F.; Scaricamazza, S.; Nesci, V.; D'Ottavio, G.; Caprioli, D.; Ferri, A.; Vila, M.; Ledonne, A.; Mercuri, N. B.
10.1101/2025.04.18.649338 — neuroscience — Posted on 2025-04-23
1403 Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic Treatment
Venkatasubramanian, R.; Mahoney, S. A.; Hutton, D. A.; VanDongen, N. S.; Brunt, V. E.; Greenberg, N. T.; Longtine, A. G.; Brandt, L.; Beyer, A. M.; Melov, S.; Campisi, J.; Rossman, M. J.; Seals, D. R.; Clayton, Z. S.
10.1101/2025.04.19.649672 — physiology — Posted on 2025-04-23
1410 TNIP1 and Autophagy Receptors Regulate STING Signaling
Bunker, E. N.; Fischer, T. D.; Zhu, P.-P.; Le Guerroue, F.; Youle, R. J.
10.1101/2025.04.21.649822 — cell biology — Posted on 2025-04-23
1411 Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles
Fan, C.; Keeffe, J. R.; Malecek, K. E.; Cohen, A. A.; West, A. P.; Baharani, V. A.; Rorick, A. V.; Gao, H.; Gnanapragasam, P. N. P.; Rho, S.; Alvarez, J.; Segovia, L. N.; Hatziioannou, T.; Bieniasz, P. D.; Bjorkman, P. J.
10.1101/2025.01.02.631145 — immunology — Posted on 2025-04-23
1412 A neuroprotective tetrapeptide for treatment of acute traumatic brain injury
Mann, A. P.; Hussain, S.; Scodeller, P.; Moore, H. N. B.; Sherazee, E.; Russo, R. M.; Ruoslahti, E.
10.1101/2025.04.17.649010 — neuroscience — Posted on 2025-04-23
1413 Small-world scale-free brain graphs from EEG
Khalili, M. D.; Abootalebi, V.; Saeedi-Sourck, H.; Santoro, A.; Behjat, H. H.
10.1101/2025.04.17.649421 — neuroscience — Posted on 2025-04-23
1415 A Context-Free Model of Savings in Motor Learning
Shahbazi, M.; Codol, O.; Michaels, J. A.; Gribble, P. L.
10.1101/2025.03.26.645562 — neuroscience — Posted on 2025-04-23
1419 Mechanistic Insights into Proteomic Mutation-Phenotype Linkages from Tiling Mutagenesis Screens
He, W.; Huang, J.-W.; Wang, Y.; Hayward, S. B.; Leuzzi, G.; Fu, R.; Wang, S.; Vaitsiankova, A.; Bedford, M. T.; Guerois, R.; Ciccia, A.; Xu, H.
10.1101/2025.04.17.649336 — bioinformatics — Posted on 2025-04-23
1420 Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes
Sawhney, R.; Ferrell, B. D.; Dejean, T.; Schreiber, Z.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.04.17.649224 — bioinformatics — Posted on 2025-04-23
1422 Fibroblasts regulate lymphatic barrier functions in a tissue dependent manner
Ejazi, S. A.; Abdulkarimu, A.; Hsiao, T.; Garcia-Vivas, R. D.; Maisel, K.
10.1101/2025.04.17.649442 — bioengineering — Posted on 2025-04-23
1423 Exploring non-invasive sexing of early chick embryos in intact eggs using Laser Speckle Contrast Imaging (LSCI) and Deep Neural Network (DNN)
Mahler, S.; Arora, A.; Readhead, C.; Yin, S.; Hari, S. N.; Wang, E.; Moxley, C. I.; Adeboye, A. A.; Dong, Z.; Zhou, H.; Chen, X.; Bronner, M.; Yang, C.
10.1101/2025.04.17.649355 — bioengineering — Posted on 2025-04-23
1424 Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential.
Hamadou, M. H.; Alunno, L.; Peroni, D.; Pancher, M.; Venturelli, T.; Belli, R.; Dassi, E.; Romanel, A.; Inga, A.
10.1101/2025.04.17.649328 — genetics — Posted on 2025-04-23
1426 Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells
Zhang, Q.; Wang, Y.; Fu, X.; Wang, Z.; Zhang, Y.; Yan, L.; Wang, Y.; Yang, M.; Song, D.; Zhang, R.; Zhang, H.; Wu, S.; Zhao, S.
10.1101/2025.04.17.649440 — cell biology — Posted on 2025-04-23
1427 Subtle Cellular Phenotypes Inform Pathological and Benign Genetic Mutants in the Iduronidase-2 Sulfatase Gene
Viswanathan, A.; Elia, S. N.; Le, S. Q.; Doray, B.; Waligorski, J. E.; Kelley, K.; Buchser, W. J.; Dickson, P. I.
10.1101/2025.04.17.649412 — cell biology — Posted on 2025-04-23
1428 Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes
Driscoll, B.; Fountain, M. B.; Gates, I. N.; Abdollahi, R.; Langley, A. M.; Owens, M. B.; Christensen, J. R.; Salogiannis, J.
10.1101/2025.04.17.649231 — cell biology — Posted on 2025-04-23
1429 SynGAP forms biocondensates at sub-micromolar concentrations and recruits PSD95 and receptor oligomers, functioning as a key initiator of PSD formation
Acharya, S.; Tsunoyama, T. A.; Hoffmann, C.; Aguilar, P. G.; Meshcheryakova, I.; Nakamura-Norimoto, A.; Mastro, T.; Walkup, W. G.; Fujiwara, T. K.; Kennedy, M. B.; Milovanovic, D.; Kusumi, A.
10.1101/2025.04.22.649955 — neuroscience — Posted on 2025-04-23
1430 Saccades orchestrate intraocular glucose to shape visual responses in birds
Xu, X.; Xiao, T.; Chen, Y.; Song, L.; Wu, C.; Wang, Q.; Zhang, T.; Yang, Y.
10.1101/2025.04.17.649318 — neuroscience — Posted on 2025-04-23
1432 M-ECG: Extracting Heart Signals with a Novel Computational Analysis of Magnetoencephalography Data
Izadysadr, A.; Bagherzadeh, H. S.; Stapleton-Kotloski, J.; Popli, G.; O`Donovan, C.; Godwin, D.
10.1101/2025.04.17.649325 — neuroscience — Posted on 2025-04-23
1435 A single vesicle fluorescence microscopy platform to quantify phospholipid scrambling
Veit, S.; Dearden, G. I.; Menon, K. M.; Noor, F.; Menon, A. K.; Pomorski, T. G.
10.1101/2025.04.17.649308 — biophysics — Posted on 2025-04-23
1440 Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition
Cotet, T.-S.; Krawczuk, I.; Pacesa, M.; Nickel, L.; Correia, B. E.; Haas, N.; Qamar, A.; Challacombe, C. A.; Kidger, P.; Ferragu, C.; Naka, A.; Castorina, L. V.; Subr, K.; Kluonis, T.; Stam, M. J.; Unal, S. M.; Wood, C. W.; Stocco, F.; Ferruz, N.; Kurumida, Y.; Calia, C. N.; Paesani, F.; Machado, L. d. A.; Belot, E.; Gitter, A.; Campbell, M. J.; Hallee, L.; Adaptyv Competition Organizers,
10.1101/2025.04.17.648362 — bioengineering — Posted on 2025-04-23
1443 Trans-ancestry Mendelian Randomization Discovers Novel Causal Genes for Autoimmune Disease Traits
Chen, S.; Wang, C.; Taylor, K.; Rotter, J.; Guo, X.; Rich, S. S.; Manichaikul, A. W.; Liu, D.
10.1101/2025.04.17.649410 — genetics — Posted on 2025-04-23
1446 Neuropilin 2 functions as a co-inhibitory receptor to regulate antigen-induced inflammation and allograft rejection
Wedel, J.; Kochupurakkal, N.; Kong, S. W.; Bose, S.; Lee, J.-W.; Maslyar, M.; Alsairafi, B.; Macleod, K.; Liu, K.; Zhang, H.; Komatsu, M.; Nakayama, H.; Bielenberg, D. R.; Briscoe, D.
10.1101/2025.04.17.648233 — immunology — Posted on 2025-04-23
1447 Respiration shapes the neural dynamics of successful remembering in humans.
Bullon Tarraso, E.; Schwimmbeck, F.; Petzka, M.; Staudigl, T.; Staresina, B. P.; Schreiner, T.
10.1101/2025.04.17.649286 — neuroscience — Posted on 2025-04-23
1448 Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease
Xiao, Y.; Spotorno, N.; An, L.; Bazinet, V.; Hansen, J. Y.; Strandberg, O.; Shafiei, G.; Bejhat, H. H.; Funck, T.; Salvado, G.; Stomrud, E.; Smith, R.; Palmqvist, S.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Palomero-Gallagher, N.; Dagher, A.; Misic, B.; Hansson, O.; Vogel, J. W.
10.1101/2025.04.17.648358 — neuroscience — Posted on 2025-04-23
1450 Single-cell and spatial detection of senescent cells using DeepScence
Qu, Y.; Ji, B.; Dong, R.; Gu, L.; Chan, C.; Xie, J.; Glass, C.; Wang, X.-F.; Nixon, A.; Ji, Z.
10.1101/2023.11.21.568150 — bioinformatics — Posted on 2025-04-23
1452 EasyMultiProfiler: An Efficient Multi-Omics Data Integration and Analysis Workflow for Microbiome Research
Liu, B.; Liu, Y.; Xu, S.; Wu, Q.; Wu, D.; Zhan, L.; Liao, Y.; Mai, Y.; Zheng, M.; Wang, S.; Chen, Y.; Huang, Z.; Luo, X.; Xie, Z.; Pan, X.; Yu, G.; Xie, L.
10.1101/2025.04.17.649266 — bioinformatics — Posted on 2025-04-23
1454 VARS-fUSI: Variable Sampling for Fast and Efficient Functional Ultrasound Imaging using Neural Operators
Tolooshams, B.; Lin, L.; Callier, T.; Wang, J.; Pal, S.; Chandrashekar, A.; Rabut, C.; Li, Z.; Blagden, C.; Norman, S. L.; Azizzadenesheli, K.; Liu, C.; Shapiro, M. G.; Andersen, R. A.; Anandkumar, A.
10.1101/2025.04.16.649237 — bioengineering — Posted on 2025-04-23
1455 Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathy
Stangner, K.; Dervishi, O.; Kuhnert, J.; Wendt, C.; Pathak, S.; Shoykhet, M.; Olivares Florez, S.; Moztarzadeh, S.; Opsteen, J.; Suniasih Wohlfarth, N. L. C.; Biller, R.; Graf, E.; Westphal, D. S.; Williams, T.; Gerull, B.; Saric, T.; Yeruva, S.; Waschke, J.
10.1101/2025.04.17.649297 — cell biology — Posted on 2025-04-23
1456 Optogenetic control of mechanotransduction based on light-induced homodimerization of talin
Nishimura, R.; Barnett, S. F. H.; Jain, K.; Huang, Z.; Goult, B. T.; Kanchanawong, P.
10.1101/2025.04.17.649301 — cell biology — Posted on 2025-04-23
1458 Exogenous Thyroxine Increases Cardiac Nrf2-TRX in Insulin Resistant OLETF Rats
Mendez, D. A.; Hernandez Garcia, J.; Sonanez-Organis, J. G.; Hernandez Garcia, M.; Vazquez-Anaya, G.; Nishiyama, A.; Vazquez-Medina, J. P.; Ortiz, R. M.
10.1101/2025.04.16.649239 — physiology — Posted on 2025-04-23
1463 Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins
Bettin, E. B.; Aghakhanian, F.; Hennelly, C.; Chen, W.; Davenport, T.; Hackl, S. T.; Grassmann, A. A.; Vargas-Cely, F.; Silva, S.; Garcia-Luna, J. A.; Ramirez, L. G.; Jiang, Y.; Yang, L.-G.; Zheng, h.; Yang, B.; Pospisilova, P.; ?majs, D.; Matoga, M. M.; Hoffman, I.; Lopez-Medina, E.; Nieselt, K.; Moody, M. A.; Sena, A. C.; Salazar, J. C.; Parr, J. B.; Caimano, M. J.; Hawley, K. L.; Radolf, J. D.
10.1101/2025.04.21.649848 — microbiology — Posted on 2025-04-23
1466 The Effects of Antidepressants on the Hippocampus: A Meta-Analysis of Public Transcriptional Profiling Data
Geoghegan, E. M.; Hagenauer, M. H.; Hernandez, E.; Espinoza, S.; Flandreau, E. I.; Nguyen, P. T.; Bhuiyan, M. R.; Mensch, S.; Watson, S. J.; Akil, H.
10.1101/2025.04.21.648805 — neuroscience — Posted on 2025-04-23
1468 Cryptovaranoides is not a squamate
Caldwell, M. W.; Brownstein, C. D.; Meyer, D. L.; Scarpetta, S. G.; Lee, M. S. Y.; Simoes, T. R.
10.1101/2025.04.18.649532 — paleontology — Posted on 2025-04-23
1471 Whole-Proteome Screening and Multi-Modal Profiling of Antigen-Specific CD4+ T Cells at Single-Cell Resolution
Zhang, R.; Qi, J.; McKasson, M.; Choi, J.; Gutierrez, V.; Brennan, C.; Hong, S.; Chour, W.; Ng, R. H.; Xie, J.; Yuan, D.; Webster, A.; Sidhu, S. K.; Anderson, A.; Chen, D.; Edmark, R.; Murray, K. M.; Li, S.; McDonald, C.; Rowen, L.; Wang, S.; Rasheed, Y.; Su, Y.; Wagner, J. R.; Chen, J.; Narwaly, K.; Fu, J.; Duven, A.; Forman, S. J.; Song, M.; Priceman, S.; Brown, C. E.; Ribas, A.; Wong, D.; Paulson, K. G.; Drescher, C. W.; Puig-Saus, C.; Goldman, J. D.; Trimble, C. L.; Heath, J. R.
10.1101/2025.04.21.649828 — bioengineering — Posted on 2025-04-23
1477 Ketamine reverses chronic stress-induced behavioral changes via Ca2+-permeable AMPA receptors in mice
Flowers, J. C.; Vetter, P. E.; Wiles, M. J.; Roh, S. H.; Black, E. R.; Bouckova, E.; Wustrau, M. H.; Lee, R.; Lee, S.-H.; Kim, S.
10.1101/2024.10.07.616991 — neuroscience — Posted on 2025-04-23
1480 Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer
Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.
10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-04-23
1481 Radiation-Induced Autophagy Regulates the Fibroblast Mitochondrial Stress Response and Crosstalk with Triple-Negative Breast Cancer Cells
Corn, K. C.; Martello, S. E.; Menon, V. K.; Britto, L. S.; Simmons, K. K.; Mohamed, Y. K.; Ivanova, Y. I.; Ghelmansaraei, A. A.; Weidenbach, S. A.; Zhu, T.; Krystofiak, E.; Young, J. D.; Gama, V.; Rafat, M.
10.1101/2022.05.17.492249 — cancer biology — Posted on 2025-04-23
1487 Social Context Restructures Behavioral Syntax in Mice
Ritter, M.; Shipley, H.; Deiana, S.; Hengerer, B.; Wotjak, C. T.; Brecht, M.; Bogadhi, A. R.
10.1101/2025.04.17.648924 — animal behavior and cognition — Posted on 2025-04-23
1488 Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang, J.; Ubas, A. A.; de Borja, R.; Svensson, V.; Thomas, N.; Thakar, N.; Winters, A.; Khan, U.; Jones, M. G.; Tran, V.; Pangallo, J.; Papalexi, E.; Sapre, A.; Nguyen, H.; Sanderson, O.; Nigos, M.; Kaplan, O.; Schroeder, S.; Hariadi, B.; Marrujo, S.; Salvino, C. C. A.; Gallareta Olivares, G.; Koehler, R.; Geiss, G.; Rosenberg, A.; Roco, C.; Merico, D.; Alidoust, N.; Goodarzi, H.; Yu, J.
10.1101/2025.02.20.639398 — genomics — Posted on 2025-04-23
1489 Gene flow can reveal ghost lineages
Tricou, T.; Marsot, E.; Boussau, B.; Tannier, E.; de Vienne, D. M.
10.1101/2024.12.11.627931 — evolutionary biology — Posted on 2025-04-23
1491 Primary and secondary microplastics do not affect hatching of Japanese flounder eggs
Azmi, S. S.; Seong, T.; Kim, H.-J.; Nakatani, H.; Kyozuka, Y.; Asakura, H.; Shimizu, K.; Yagi, M.
10.1101/2025.04.15.648670 — developmental biology — Posted on 2025-04-23
1495 Origins and evolutionary trajectories of morbilliviruses in Neotropical bats
Jo, W. K.; Moreira-Soto, A.; Campos, A. A.; Goes, L. G. B.; Mares-Guia, M. A.; Rasche, A.; Bispo de Filippis, A.; Hernandez-Mora, G.; Nambulli, S.; Streicker, D.; Duprex, W. P.; Drexler, J. F.; bat morbillivirus consortium,
10.1101/2025.03.18.643905 — microbiology — Posted on 2025-04-23
1496 Enhancement and validation of the antibiotic resistance prediction performance of a cloud-based genetics processing platform for Mycobacteria
Westhead, J.; Baker, C. S.; Brouard, M.; Colpus, M.; Constantinides, B.; Hall, A.; Knaggs, J.; Lopes Alves, M.; Spies, R.; Thai, H.; Surrall, S.; Govender, K.; Peto, T. E.; Crook, D. W.; Omar, S. V.; Turner, R.; Fowler, P. W.
10.1101/2024.11.08.622466 — microbiology — Posted on 2025-04-23
1500 An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality
Whitman, E. T.; Elliott, M. L.; Knodt, A. R.; Abraham, W. C.; Anderson, T. J.; Cutfield, N.; Hogan, S.; Ireland, D.; Melzer, T. R.; Ramrakha, S.; Sugden, K.; Theodore, R.; Williams, B. S.; Caspi, A.; Moffitt, T. E.; Hariri, A. R.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.08.19.608305 — neuroscience — Posted on 2025-04-23
1504 Benchmarking AlphaFold3-like Methods for Protein-Peptide Complex Prediction
Zhou, F.; Guo, S.; Peng, X.; Zhang, S.; Men, C.; Duan, X.; Zhu, G.; Wang, Z.; Li, W.; Mu, Y.; Zheng, L.; Liu, H.; Wang, S.
10.1101/2025.03.09.642277 — bioinformatics — Posted on 2025-04-23
1505 Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot
Zhu, L.; Nguyen, L. T.; Bell, A. G.; Gillmann, K. M.; Oatman, H.; Hariri, J.; Myhrvold, C.; Toettcher, J. E.
10.1101/2025.04.21.649818 — bioengineering — Posted on 2025-04-23
1508 Pollen Diet and Sterol Provisioning Differentially Affected Larval Development in a Generalist Solitary Bee
Martel, C.; Kreidt, J.; Furse, S.; Jennifer Scott, J.; Griffiths-Lee, J.; Wright, G. A.; Stevenson, P. C.
10.1101/2025.04.21.649687 — developmental biology — Posted on 2025-04-23
1510 Decisional reference point pathology: a mechanism and marker for major depressive disorder in humans
Vittala, A.; Wu, L.; Yan, D.; Liebers, D.; Tell, E.; Song, X.; Dashti, D.; Louie, K.; Raio, C.; Iosifescu, D. V.; Glimcher, P.
10.1101/2025.04.18.649538 — neuroscience — Posted on 2025-04-23
1511 WITHDRAWN: SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology
Shen, W.-B.; Elahi, M.; Logue, J.; Yang, P.; Baracco, L.; Reece, E. A.; Wang, B.; Li, L.; Blanchard, T.; Han, Z.; Frieman, M.; Rissman, R. A.; Yang, P.
10.1101/2022.01.31.478476 — neuroscience — Posted on 2025-04-23
1514 TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons
McGuinness, W.; Ryan, B. J.; Guardado, C. L.; Carling, P.; Vallin, B.; Caiazza, M. C.; Heon-Roberts, R.; Kilfeather, P.; Wantling, J.; Hoffmann, J.; Aird, D.; Lofstromm, K.; Zhang, M.; Cowley, S. A.; Hirst, W. D.; Wade-Martins, R.
10.1101/2025.04.22.649949 — cell biology — Posted on 2025-04-23
1515 Auditory Brainstem Development in Autism: From Childhood Hypo-Responsivity to Adult Hyper-Reactivity
Seif, A. A.; Guerville, R.; Rajab, M. S.; Marceau-Linhares, C.; Schaaf, K.; Schmid, S.; Stevenson, R. A.
10.1101/2025.04.22.650041 — neuroscience — Posted on 2025-04-23
1516 Programmatic design and editing of cis-regulatory elements
Schreiber, J.; Lorbeer, F. K.; Heinzl, M.; Lu, Y.; Stark, A.; Noble, W. S.
10.1101/2025.04.22.650035 — bioinformatics — Posted on 2025-04-23
1519 Transcriptomes of higher order thalamic nuclei in obsessive compulsive disorder
Springer, S.; Deshmukh, R.; Klei, L.; Devlin, B.; Glausier, J. R.; Lewis, D. A.; Ahmari, S.
10.1101/2025.04.22.650032 — neuroscience — Posted on 2025-04-23
1526 A General Framework for Predicting the Temperature-Dependence of Microbial Interactions
Duan, Q.; Harcombe, W. R.; Savage, V.; Mustri, M. P.; Smith, T. P.; Pawar, S.
10.1101/2025.04.18.649480 — ecology — Posted on 2025-04-22
1528 At the Southern Limit: The Arenal Central Site and the Guarani Occupation of the Parana Delta (Argentina)
Loponte, D.; Carbonera, M.; Schneider, F.; Galarce Machado, N.; Bertoncello, A.; Telles Szczygel, M.; Acosta, A.; Mazza, B.; Sheila, A.; Capparelli, I.
10.1101/2025.04.21.648367 — zoology — Posted on 2025-04-22
1529 Spatial proteomics with 100+ markers with Highly Multiplexed MALDI-IHC
Zhang, M.; Abbey, J. A.; Bost, P.; Usui, G.; Haefliger, S.; Muenst, S.; Lim, M. J.; Yagnik, G. B.; De Souza, N.; Rothschild, K. J.; Bodenmiller, B.
10.1101/2025.04.18.649415 — systems biology — Posted on 2025-04-22
1530 Single Nuclei-Derived Molecular Subtypes of Gastrointestinal Stromal Tumors Correlate with Clinicopathologic Features and Predict Clinical Outcomes
Sharma, A. K.; Wenzel, A. T.; Jun, J.; Guragain, D.; Tang, C.-M.; Antkowiak, M.; Bhargava, S.; Burgoyne, A. M.; Fanta, P.; Munter, S. E.; Chen, K. Y.; Doherty, T. M.; Murugesan, M.; Sanchez-Fernandez, A.; Malli, S.; Mundi, P. S.; Rothschild, S.; Evans, D.; Kim, W.; Schwartz, G. K.; Califano, A.; Tamayo, P.; Mesirov, J. P.; Sicklick, J. K.
10.1101/2025.04.21.647322 — cancer biology — Posted on 2025-04-22
1534 Timing of independence is explained by movement ability, but depends on how independence is defined for a long-lived raptor
Bronnvik, H.; Scacco, M.; Chimento, M.; Bassi, E.; Hatzl, J. S.; Sumasgutner, P.; Tschumi, M.; Wikelski, M.; Zimmermann, S.; Safi, K.; Nourani, E.
10.1101/2025.04.21.649390 — animal behavior and cognition — Posted on 2025-04-22
1535 eDNA metabarcoding and whole genome sequencing detect European-American Eel hybrids in northeastern Canada
Crowley, S.; Kess, T.; Bentzen, P.; Neville, V.; Bloom, C.; Smith, N.; Fahner, N.; Berghuis, L.; Hobrecker, K.; Hajibabaei, M.; Duffy, S.; Bradbury, I.
10.1101/2025.04.21.649106 — genomics — Posted on 2025-04-22
1536 Stepwise recombination suppression around the mating-type locus associated with a diploid-like life cycle in Schizothecium fungi
De Filippo, E.; Chahine, E.; Legendre--Despas, J.; Snirc, A.; Labat, A.; Michel, P.; Grognet, P.; Gautier, V.; Levert, E.; Lalanne, C.; Silar, P.; Giraud, T.; Hartmann, F. E.
10.1101/2025.04.18.645578 — evolutionary biology — Posted on 2025-04-22
1546 Microbiota-derived secondary bile acids promote STING activation and antitumor activity
Yang, X.; Zhang, X.; Li, W.; Gharpure, A.; Hansel-Harris, A.; Tillack, A. F.; Wu, C.; Hsieh, Y.-Z.; Sulpizio, A.; Dikiy, S.; Zhao, X.; Forli, S.; Lairson, L.; Ward, A.; Parker, C. G.; Hang, H.
10.1101/2025.04.16.649255 — immunology — Posted on 2025-04-22
1547 Bioprospection of culturable soil-borne bacteria with biotechnological potential for use in priming defense
Gonzalez - Arriagada, M.; Ortega, J.; Torres, J.; Sulbaran, Y.; Flores, S.; Bastidas, B.; Montero-Morales, P.; Aceituno-Valenzuela, U.; Alvarez, A.; Contreras-Soto, R.; San Blas, E.; Latorre, M.; Pizarro, L.
10.1101/2025.04.21.649657 — immunology — Posted on 2025-04-22
1548 Wearable, High-Density, Time-Domain Diffuse Optical Tomography Array for Functional Neuroimaging
Renehan, K.; Kim, J.; Yin, H.; Wang, F.; Petridis, P. D.; Grinband, J.; Kim, S. H.; Hielscher, A. H.; Shepard, K.
10.1101/2025.04.22.649003 — neuroscience — Posted on 2025-04-22
1549 YOTO (You Only Think Once): A Human EEG Dataset for Multisensory Perception and Mental Imagery
Chang, Y.-H.; Chen, H.-A.; Tsai, M.-J.; Tseng, C.-L.; Lo, C.-H.; Huang, K.-C.; Wei, C.-S.
10.1101/2025.04.17.645384 — neuroscience — Posted on 2025-04-22
1551 How Acting Jointly Differs from Acting Side-by-Side: A Dual EEG Study
Fanghella, M.; Mussini, E.; Zazio, A.; Genovese, F.; Satta, E.; Barchiesi, G.; Battaglia Mayer, A.; Bortoletto, M.; Sinigaglia, C.
10.1101/2025.04.18.649548 — neuroscience — Posted on 2025-04-22
1552 Rif-seq reveals Caulobacter crescentus mRNA decay is globally coordinated with transcription and translation
Kulathungage, H.; Aretakis, J. R.; Vaidya, K.; Al-Husini, N.; Muthunayake, N. S.; Kim, S.; Schrader, J. M.
10.1101/2025.04.22.648521 — systems biology — Posted on 2025-04-22
1553 Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis
Lopez-Unzu, M. A.; Pricolo, M. R.; Silva-Rojas, R.; Clemente-Manteca, A.; Sanchez-Ortiz, D.; Vicente, N.; Velazquez-Carreras, D.; Morales, C.; Gavilan-Herrera, M.; Sen-Martin, L.; Fernandez-Trasancos, A.; Labrador-Cantarero, V.; Sanchez-Garcia, L.; Relano-Ruperez, C.; Sanchez-Cabo, F.; Lalaguna, L.; Isern, J.; Munoz-Canoves, P.; Sabio, G.; Lara-Pezzi, E.; Herrero-Galan, E.; Alegre-Cebollada, J.
10.1101/2025.04.22.645683 — physiology — Posted on 2025-04-22
1555 Molecular and Epigenetic Pathways Underlying Epithelial Damage and Repair in Necrotizing Enterocolitis via Multi-omics Approach
Xiong, Y.; Zito, A.; Liang, H.; Biouss, G.; Yang, J.; Balsamo, F.; Yeganeh, M.; Lee, C.; Lee, D.; Wang, C.-Y.; Tahmasian, N.; Huang, J.; Minich, A.; Feizi, M.; Wang, S.; Tian, Y.; De Coppi, P.; Kalish, B.; Olguin, P. D.; Zhu, H.; Li, B.; Pierro, A.
10.1101/2025.04.17.647851 — pathology — Posted on 2025-04-22
1558 Molecular Basis of EWS Interdomain Self-Association and Its Role in Condensate Formation
Sohn, E. J.; Sojitra, K. A.; Rodrigues, L.; Xu, X.; Frost, B.; Mittal, J.; Libich, D. S.
10.1101/2025.04.16.649245 — biophysics — Posted on 2025-04-22
1559 Detecting cell-level transcriptomic changes of Perturb-seq using Contrastive Fine-tuning of Single-Cell Foundation Models
Zhao, W.; Solaguren-Beascoa, A.; Neilson, G.; Reynolds, R.; Muhammed, L.; Laaniste, L.; Cakiroglu, S. A.
10.1101/2025.04.17.649395 — bioinformatics — Posted on 2025-04-22
1561 Multi-modal single-cell foundation models via dynamic token adaptation
Zhao, W.; Solaguren-Beascoa, A.; Neilson, G.; Muhammed, L.; Laaniste, L.; Cakiroglu, S. A.
10.1101/2025.04.17.649387 — bioinformatics — Posted on 2025-04-22
1564 Engineering patient-derived organotypic bone models for skeletal disease and osteoanabolic therapy testing
de Leeuw, A.; Steffi, C.; Schädli, G. N.; Singh, A.; Lim, P. J.; Rohrbach, M.; Giunta, C.; Rüger, M.; Müller, R.
10.1101/2025.04.17.649276 — bioengineering — Posted on 2025-04-22
1566 BTRR complex deficiency is a driver for genomic instability in Bloom syndrome
Gönenc, I. I.; Wolff, A.; Busley, A. V.; Wieland, A.; Tijhuis, A.; Müller, C.; Wardenaar, R.; Argyriou, L.; Kaulfuss, S.; Räschle, M.; Spierings, D. C. J.; Foijer, F.; Bastians, H.; Yigit, G.; Zibat, A.; Cyganek, L.; Wollnik, B.
10.1101/2025.04.17.649287 — genetics — Posted on 2025-04-22
1567 The PERPETUAL FLOWERING Locus: Necessary But Insufficient for Genomic Prediction of Runnerless and Other Asexual Reproduction Phenotypes in Strawberry
Brukental, H.; Bjornson, M. L.; Pincot, D. D. A.; Hardigan, M. A.; Sharma, S.; Jimenez, N. P.; Famula, R. A.; Lopez Ramirez, C. M.; Cole, G. S.; Feldmann, M. J.; Knapp, S. J.
10.1101/2025.04.20.646347 — genetics — Posted on 2025-04-22
1568 μSeq: Universal mutation rate quantification via deep sequencing of a single clonal expansion.
Pompei, S.; Geroldi, A.; Rivetti, P.; Grassi, E.; Vurchio, V.; Tallarico, G.; Corti, G.; Tattini, L.; Liti, G.; Bertotti, A.; Cosentino Lagomarsino, M.
10.1101/2025.04.17.649315 — evolutionary biology — Posted on 2025-04-22
1573 Compartmentalization of mRNA and Translation by Desmosomes
D'Alessandro, A.; Badu-Nkansah, K.; Link, S.; Hlavaty, D.; Bjerke, G.; Nicchitta, C. V.; Yi, R.; Lechler, T.
10.1101/2025.04.17.649424 — cell biology — Posted on 2025-04-22
1577 Impact of the RaS-RiPP tryglysin and culturing conditions on ex-vivo oral microbiomes.
Rued, B. E.; Dhariwal, A.; Covington, B. C.; Seyedsayamdost, M. R.; Krivograd, S. A.; Pesavento, R. P.; Federle, M. J.; Petersen, F. C.
10.1101/2025.04.21.649776 — microbiology — Posted on 2025-04-22
1583 Neutrophils respond with pathogen-specific defenses during bacterial pneumonia
Pihl, R.; Martins, K.; Lee, Y.; Patneaude, L.; Quinton, L.; Mizgerd, J.; Belkina, A.; Traber, K.
10.1101/2025.04.17.649365 — immunology — Posted on 2025-04-22
1584 On-Body Measure of Reaction Time Correlates With Intoxication Level
Blackwell, M.; Valk, H.; Eaton, J.; Kovaly, S.; Karnes, S.; Vu, T.; Stevenson, K.; Kowalczyk, M.; Gormley, W. B.
10.1101/2025.04.17.649358 — neuroscience — Posted on 2025-04-22
1586 Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cells
Mariani, J. N.; Schanz, S. J.; Mansky, B.; Wei, X.; Long, C. C.; Chandler-Militello, D.; Huynh, N. P. T.; Goldman, S. A.
10.1101/2025.04.22.649367 — neuroscience — Posted on 2025-04-22
1587 Optically detected and radio wave-controlled spin chemistry in cryptochrome
Meng, K.; Nie, L.; Berger, J.; von Grafenstein, N. R.; Einholz, C.; Rizzato, R.; Schleicher, E.; Bucher, D. B.
10.1101/2025.04.16.649006 — biophysics — Posted on 2025-04-22
1589 AAVs Targeting Human Carbonic Anhydrase IV Enhance Gene Delivery to the Brain
Lin, C.; Chen, X.; Hoang, J. D.; Ristic, F.; Fan, Y.; Jang, S.; Chung, J. H. A.; Sullivan, E. E.; Gawda, T.; Kavvathas, B.; Tran, I.; Li, Y.; Steele, A. D.; Shay, T. F.; Gradinaru, V.
10.1101/2025.04.21.649868 — bioengineering — Posted on 2025-04-22
1590 Real-Time Wide-Field Fluorescence Lifetime Imaging via Single-Snapshot Acquisition for Biomedical Applications
Pandey, V.; Millar, E.; Erbas, I.; Chavez, L. M.; Radford, J.; Crosbourne, I.; Madhusudan, M.; Taylor, G. G.; Yuan, N.; Bruschini, C.; Radev, S. T.; Barroso, M.; Tobin, A. B.; Michalet, X. B.; Charbon, E.; Faccio, D.; Intes, X.
10.1101/2025.04.16.646646 — bioengineering — Posted on 2025-04-22
1591 Development of CRISPR/Cas13-based analytical tools to study RNA-Protein Interactions
Yamamoto, K.; Shikata, S.; Hao, Y.; Tomita, T.; Verhoeyen, E.; Saeki, Y.; Goyama, S.
10.1101/2025.04.22.649962 — bioengineering — Posted on 2025-04-22
1593 Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search
Mäeots, M.-E.; Tupin, S.; Esfahani, N. M. M.; Molina, J. B. R.; Clapperton, J. A.; Amin, A.; Imbert, A.; Enchev, R. I.
10.1101/2025.04.21.649820 — biochemistry — Posted on 2025-04-22
1594 Structural insight into binding of novel PET tracer MODAG-005 to lipidic ????-Synuclein fibrils
Kim, M.; Matthes, D.; Frieg, B.; Leonov, A.; Ryazanov, S.; Bleher, D.; Grotegerd, A.-K.; Dienemann, C.; Giese, A.; Schröder, G. F.; Becker, S.; Herfert, K.; Groot, B. L. d.; Andreas, L. B.; Griesinger, C.
10.1101/2025.04.21.649837 — biochemistry — Posted on 2025-04-22
1595 Sustained MYB activity drives emergent enhancer activation and precise enhancer-promoter interactions
Lau, I.-J.; Harman, J. R.; Smith, A. L.; Denny, N.; Jackson, N. E.; Hamley, J. C.; Vyas, P.; Davies, J. O. J.; Hughes, J. R.; Crump, N. T.; Milne, T. A.
10.1101/2025.04.16.649256 — genomics — Posted on 2025-04-22
1596 Factors Influencing Emerald Ash Borer Ecological Interactions
Borsato, N. D.; McFarlane, E.; Garrett, N.; Biganzoli-Rangel, A.; Marquina, D.; Steinke, D. R.; Floyd, R.; Clare, E.
10.1101/2025.04.16.649187 — ecology — Posted on 2025-04-22
1597 Do epidemiologically impactful vector control interventions disrupt mosquito population structure?
Dennis, T. P. W.; Guelbeogo, W. M.; Ferguson, H. M.; Lindsay, S.; N'Fale, S.; Pignatell, P.; Ranson, H.; Sanou, A.; Tiono, A.; Weetman, D.; Viana, M.
10.1101/2025.04.16.649034 — ecology — Posted on 2025-04-22
1598 Long-read transcriptome-wide RNA structure maps using DMS-FIRST-seq
Begik, O.; Diensthuber, G.; Borovska, I.; Mattick, J. S.; Incarnato, D.; Novoa, E. M.
10.1101/2025.04.22.649934 — molecular biology — Posted on 2025-04-22
1599 Endothelial Prolyl Hydroxylase 3 Mitigates Maladaptive Inflammation to Promote Post-Ischemic Kidney Repair
Sharma, R.; Tiwari, R.; O'Sullivan, J.; Borkowski, G. S.; An, S. Y.; Thorp, E. B.; Chandel, N. S.; Quaggin, S. E.; Kapitsinou, P. P.
10.1101/2025.04.21.649850 — molecular biology — Posted on 2025-04-22
1601 Particle attachment drives seasonal abundance and photoheterotrophy of marine aerobic anoxygenic phototrophs
Villena-Alemany, C.; Vrdoljak Tomas, A.; Mujakic, I.; Kopejtka, K.; Santic, D.; Koblizek, M.
10.1101/2025.04.22.649935 — microbiology — Posted on 2025-04-22
1602 Adeno-Associated Virus 2 (AAV2) - induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression
Summers, M. F.; Haubold, M. K.; Morgenstern, M.; Shepherd, P.; Larsen, C. I.; Bartz, A. E.; Thirumoorthy, G.; Kirchdoerfer, R. N.; Coon, J. J.; Mehta, K. P.; Majumder, K.
10.1101/2025.04.22.649920 — microbiology — Posted on 2025-04-22
1603 RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking.
Gad, S. A.; Hussein, S. A.; Fukano, K.; Kato, T.; Shoji, I.; Chayama, K.; Muramatsu, M.; Isogawa, M.; Wakita, T.; Merk, D.; Aly, H. H.
10.1101/2025.04.21.649881 — microbiology — Posted on 2025-04-22
1604 Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice
Bamunuarachchi, G.; Zhao, F.; Bricker, T. L.; Seehra, K.; Karp, A.; Diamond, M.; Boon, A. C.
10.1101/2025.04.21.649883 — microbiology — Posted on 2025-04-22
1610 Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Snell, L. B.; Pickering, S.; Alcolea-Medina, A.; Winstone, H.; Seow, J.; Graham, C.; O'Connell, L.; Batra, R.; Malim, M. H.; Doores, K. J.; Nebbia, G. D.; Edgeworth, J.; Neil, S.; Galao, R. P.
10.1101/2025.04.17.648944 — microbiology — Posted on 2025-04-22
1611 Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure
Castagna, V. C.; Boero, L. E.; Di Guilmi, M. N.; Fuchs, P. A.; Lauer, A. M.; Elgoyhen, A. B.; Gomez-Casati, M. E.
10.1101/2025.01.03.631257 — neuroscience — Posted on 2025-04-22
1612 Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions
Khan, S. M.; Wang, A. Z.; Desai, R. R.; McCornack, C. R.; Sun, R.; Dahiya, S. M.; Foltz, J. A.; Sherpa, N. D.; Leavitt, L.; West, T. R.; Wang, A. F.; Krbanjevic, A.; Choi, B. D.; Leuthardt, E. C.; Patel, B.; Charest, A.; Kim, A. H.; Dunn, G. P.; Petti, A. A.
10.1101/2025.04.04.647096 — cancer biology — Posted on 2025-04-22
1613 The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus
Huang, Y.-N.; Jaiswal, P. V.; Rajesh, A.; Yadav, A.; Yu, D.; Liu, F.; Scheg, G.; Boldirev, G.; Nakashidze, I.; Mehta, J. H.; Wang, K.; Patel, K. K.; Sarkar, A.; Mirza, M. A. B.; Hu, J.; Peng, Q.; Hapani, K. C.; Ayyala, R.; Guo, R.; Wong, M. Y.; Kapur, S.; Ramesh, T.; Abedalthagafi, M. S.; Mangul, S.
10.1101/2021.11.22.469640 — bioinformatics — Posted on 2025-04-22
1615 Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy
Wang, Q.; Jia, Y.; Smid, H.; Weldegergis, B.; Greenberg, L.; Jongsma, M.; Dicke, M.; Haverkamp, A.
10.1101/2024.12.17.629055 — ecology — Posted on 2025-04-22
1618 Mind the blank: behavioral, experiential, and physiological signatures of absent-mindedness
Musat, E. M.; LeCoz, A.; Corcoran, A. W.; Belloli, L.; Naccache, L.; Andrillon, T.
10.1101/2024.02.11.579845 — neuroscience — Posted on 2025-04-22
1619 Feedback of peripheral saccade targets to early foveal cortex
Kaemmer, L.; Kroell, L. M.; Knapen, T.; Rolfs, M.; Hebart, M. N.
10.1101/2025.02.20.639262 — neuroscience — Posted on 2025-04-22
1621 Increased listening effort and cochlear neural degeneration underlie behavioral deficits in speech perception in noise in normal hearing middle-aged adults.
Zink, M. E.; Zhen, L.; McHaney, J. R.; Klara, J.; Yurasits, K.; Cancel, V.; Flemm, O.; Mitchell, C.; Datta, J.; Chandrasekaran, B.; Parthasarathy, A.
10.1101/2024.08.01.606213 — neuroscience — Posted on 2025-04-22
1623 An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes
Furlanis, E.; Dai, M.; Leyva Garcia, B.; Tran, T.; Vergara, J.; Pereira, A.; Gorissen, B. L.; Wills, S.; Vlacho, A.; Hairston, A.; Dwivedi, D.; Du, S.; McMahon, J.; Huang, S.; Morabito, A.; Vazquez, A.; Kim, S.; Lee, A. T.; Chang, E. F.; Razzaq, T.; Qazi, A.; Vargish, G.; Yuan, X.; Caccavano, A.; Hunt, S.; Chittajallu, R.; McLean, N.; Hewit, L.; Paranzino, E.; Rice, H.; Cummins, A. C.; Plotnikova, A.; Mohanty, A.; Tangen, A. C.; Shin, J. H.; Azadi, R.; Eldridge, M. A. G.; Alvarez, V. A.; Averbeck, B. B.; Alyahyay, M.; Reyes Vallejo, T.; Soheib, M.; Vattino, L. G.; MacGregor, C. P.; Chatain, C.
10.1101/2024.07.17.603924 — neuroscience — Posted on 2025-04-22
1626 Population analysis and immunologic landscape of melanoma in people living with HIV
Barger, L. N.; Wang, D.; Saravia, A.; Mezzano, V.; Ward, G.; Loomis, C.; Feldman, C.; Tuluc, M.; Seedor, R. S.; Gaskill, P. J.; Coghill, A. E.; Suneja, G.; Dehzangi, I.; Hope, J. L.; Jour, G.; Romano, G.
10.1101/2025.04.17.648995 — cancer biology — Posted on 2025-04-22
1627 Expression of a RAS degrader via synthetic nanocarrier-mediated mRNA delivery reduces pancreatic tumors
Escher, T. E.; Yuk, S. A.; Qian, Y.; Qiang, W.; Almunif, S.; Sharma, S.; Scott, E. A.; Satchell, K. J.
10.1101/2024.06.11.598439 — cancer biology — Posted on 2025-04-22
1630 Redefining the timing and circumstances of cat domestication, their dispersal trajectories, and the extirpation of European wildcats
Doherty, S.; Krajcarz, M.; Carmagnini, A.; Dimopoulos, E.; Jamieson, A.; Alves, J. M.; Balasescu, A.; Baker, P.; Baranowski, P.; Beglane, F.; Bitz-Thorsen, J.; Bolton, A.; Bowden, W.; Britton, H.; De Cupere, B.; De Martino, M.; Donnelly-Symes, B.; Evin, A.; Fowler, T.; Fulford, M.; Gotfredsen, A. B.; Han, Y.; Kitchener, A. C.; Knapp, Z.; Luo, S.-J.; Mainland, I.; Maricevic, D.; Moody, S.; Nesnidaloa, T.; O'Connor, T.; Orton, D. C.; Peters, J.; Sadebeck, F.; Siegenthaler, A.; Smallman, R.; Suvova, Z.; Symmons, R.; Sudds, J.; Thomas, G.; Van Neer, W.; Wilczynski, J.; Ottoni, C.; Popovic, D.; Fra
10.1101/2025.03.28.645877 — zoology — Posted on 2025-04-22
1631 Integrating population-level and cell-based signatures for drug repositioning
He, C.; Xu, Y.; Zhou, Y.; Fan, J.; Cheng, C.; Meng, R.; Gamazon, E. R.; Zhou, D.; Pan, R.; Wu, L.; Shah, R. V.
10.1101/2023.10.25.564079 — bioinformatics — Posted on 2025-04-22
1632 Facilitating genome annotation using ANNEXA and long-read RNA sequencing
Hoffmann, N.; Besson, A.; Cadieu, E.; Lorthiois, M.; Le Bars, V.; Houel, A.; Hitte, C.; Andre, C.; Hedan, B.; Derrien, T.
10.1101/2025.04.16.648718 — bioinformatics — Posted on 2025-04-22
1633 MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography
Lamm, L.; Zufferey, S.; Zhang, H.; Righetto, R. D.; Waltz, F.; Wietrzynski, W.; Yamauchi, K. A.; Burt, A.; Liu, Y.; Martinez-Sanchez, A.; Ziegler, S.; Isensee, F.; Schnabel, J. A.; Engel, B. D.; Peng, T.
10.1101/2024.01.05.574336 — bioinformatics — Posted on 2025-04-22
1634 circDesign Algorithm for Designing Synthetic Circular RNA
Xu, C.; Pu, C.; Chen, R.; Wang, W.; Jiang, F.; Deng, C.; Zhai, D.; Chen, Y.; Hu, W.; Zhang, Y.; Tang, Y.; Wang, Q.; An, J.; Wang, H.; Wu, J.; Wang, X.; Liu, M.; Shen, H.; Huang, L.; Zhong, Z.; Tan, W.; Liu, D.; Zhang, L.
10.1101/2023.07.09.548293 — bioengineering — Posted on 2025-04-22
1635 Discovery of a wide variety of α-1,6-cyclized β-1,2-glucan synthases: a new entrance for host-microbe interactions.
Motouchi, S.; Kim, I.; Ishiguro, A.; Niu, K.; Komba, S.; Kashima, T.; Kitano, Y.; Nakai, H.; Nakajima, M.
10.1101/2025.04.21.649730 — biochemistry — Posted on 2025-04-22
1636 Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones
Carrington, J. T.; Wilson, R. H.; de La Vega, E.; Thiyagarajan, S.; Barker, T.; Catchpole, L.; Durrant, A.; Knitlhoffer, V.; Watkins, C.; Gharbi, K.; Nieduszynski, C. A.
10.1101/2024.04.28.591325 — genomics — Posted on 2025-04-22
1637 Connectome-based brain fingerprints predict early cognitive decline in Parkinson's patients with minor hallucinations
Stampacchia, S.; Bernasconi, F.; Van De Ville, D.; Amico, E.; Pagonabarraga, J.; Kulisevsky, J.; Blanke, O.
10.1101/2025.04.17.649310 — neuroscience — Posted on 2025-04-22
1638 Mapping Serotonergic Dynamics using Drug-Modulated Molecular Connectivity
Ionescu, T. M.; Amend, M.; Hafiz, R.; Maurer, A.; Biswal, B. B.; Wehrl, H. F.; Herfert, K.
10.1101/2024.02.08.579462 — neuroscience — Posted on 2025-04-22
1639 Proteomic Remodeling During Tumor Cell-Induced Platelet Aggregation Unveils Metastatic Drivers in Colorectal Cancer
Sauer, T.; Gruner, C.; Kern, K.; Rackisch, A.; Tischner, L.; Schulz, K.; Ostermann, J.; Cohrs, L.; Kohl, M.; Verschoor, A.; Gemoll, T.
10.1101/2025.04.09.647951 — cancer biology — Posted on 2025-04-22
1640 PriMAT: A robust multi-animal tracking model for primates in the wild
Vogg, R.; Nuske, M.; Weis, M. A.; Luddecke, T.; Karakoc, E.; Ahmed, Z.; Pereira, S.; Malaivijitnond, S.; Meesawat, S.; Murphy, D.; Fischer, J.; Worgotter, F.; Kappeler, P. M.; Gail, A.; Ostner, J.; Schulke, O.; Fichtel, C.; Ecker, A. S.
10.1101/2024.08.21.607881 — animal behavior and cognition — Posted on 2025-04-22
1642 Inferring domestic goat demographic history through ancient genome imputation
Erven, J. A. M.; Etourneau, A.; Mashkour, M.; Neupane, M.; Bardou, P.; Stella, A.; Talenti, A.; Masiga, C. W.; Van Tassel, C. P.; Clark, E. L.; Pompanon, F.; Colli, L.; Amallis, M.; Milanesi, M.; Crepaldi, P.; Consortium, T. V.; Servin, B.; Rosen, B.; Tosser-Klopp, G.; Daly, K. G.
10.1101/2025.04.18.649576 — genomics — Posted on 2025-04-22
1644 Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.
Walker, A.; Olaizola, P.; Brennan, E.; Jarman, E. J.; Yao, Y.; Carmichael, E.; Gradinaru, A.; Loftus, A. E. P.; Wilson, D. H.; Martinez Lyons, A.; Charlton, L.; Ober-Vliegen, K.; Mi, W.; Broeders, A.; Davies, K.; Carragher, N.; Unciti-Broceta, A.; Kendall, T. J.; J.W. van der Laan, L.; Verstegen, M.; Frame, M. C.; Waddell, S. H.; Boulter, L.
10.1101/2025.04.21.649531 — cell biology — Posted on 2025-04-22
1645 Evaluation of nanopore sequencing for increasing accessibility of eDNA studies in biodiverse countries
Gygax, D.; Ramirez, S.; Chibesa, M.; Simpamba, T.; Riffel, M.; Riffel, T.; Srivathsan, A.; Nijland, R.; Urban, L.
10.1101/2025.04.21.649756 — molecular biology — Posted on 2025-04-22
1646 Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA
Casu, B.; Sallmen, J. W.; Haas, P. E.; Chandra, G.; Afanasyev, P.; Xu, J.; Pilhofer, M.; Schlimpert, S.
10.1101/2024.06.25.600559 — microbiology — Posted on 2025-04-22
1647 Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression Trajectories
Grimm, S. L.; Jangid, R.; Bartolomei, M. S.; Dolinoy, D. C.; Aylor, D. L.; Mutlu, G. M.; Biswal, S.; Zhang, B.; Wang, T.; TaRGET II Consortium, ; Coarfa, C.; Walker, C. L.
10.1101/2025.04.21.649824 — genomics — Posted on 2025-04-22
1649 BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Bonjoch, J.; Sola, P.; Reina, O.; Mortimer, T.; Miroshnikova, Y. A.; Wickstrom, S.; Stephan-Otto Attolini, C.; Alvarez, L.; Aznar Benitah, S.; Solanas, G.
10.1101/2025.04.22.649967 — molecular biology — Posted on 2025-04-22
1650 Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapse
Senevirathne, S. E.; Kanagy, W. K.; Cattley, R. T.; Swanson, W. L.; Ramos, S. T.; Nunez, M. G.; Hawse, W. F.; Freedman, T. S.
10.1101/2025.04.16.648985 — immunology — Posted on 2025-04-22
1651 Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans
Khan, R.; Guzman, G. U.; Do, T. H.; Devlin, P.; Ahn, J. J.; Tan, C.; Venna, V. R.; Marrelli, S. P.; Koochak, H. P.; DiGesu, C.; Flores, A.; McCullough, L. D.; Ritzel, R. M.
10.1101/2025.04.16.649173 — neuroscience — Posted on 2025-04-22
1652 Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay
Xu, W.; Keith, A. M.; Ye, W.; Hu, X.; Southall, N.; Juan, M. J.; Ferrer, M.; Henderson, M. J.; Sexton, P. M.; Deganutti, G.; Eiden, L. E.
10.1101/2025.04.16.649181 — pharmacology and toxicology — Posted on 2025-04-22
1653 Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor
Amiri, S.; Aghanoori, M.-R.; Smith, D. R.; Waise, T. M. Z.; Lao, Y.; Inoue, A.; Zahedi, R.; Dunn, H. A.; Fernyhough, P.
10.1101/2025.04.16.649213 — pharmacology and toxicology — Posted on 2025-04-22
1656 Ionic liquid-coated lipid nanoparticles promote enhanced red blood cell hitchhiking
Khare, P.; Edgecomb, S. X.; Hamadani, C. M.; Taylor, G. R.; Caprara, R.; Tanner, E. E. L.; Manickam, D. S.
10.1101/2025.04.16.649225 — bioengineering — Posted on 2025-04-22
1658 Single cell resolution of an epigenetic signature of persister tumor cell
Dumbrava, M.; Ismail, W. M.; Sandoval, L.; Mazzone, A.; Aalam, S. M. M.; Ritting, M. L.; Hou, X.; Xie, Y.; Harrington, S.; Kaufmann, S.; Kannan, N.; Weroha, S.; Gaspar-Maia, A.
10.1101/2025.04.16.649175 — genomics — Posted on 2025-04-22
1659 Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation
Pricolo, M. R.; Lopez-Unzu, M. A.; Vicente, N.; Morales-Lopez, C.; Huerta-Lopez, C.; Perez-Franco, W.; Dumitru, A. C.; Espinosa, F. M.; Sanchez, M. I.; Garcia, R.; Silva-Rojas, R.; Herrero-Galan, E.; Alegre-Cebollada, J.
10.1101/2025.04.22.645658 — cell biology — Posted on 2025-04-22
1660 Early epigenetic priming of regeneration studied with a novel transgenic epigenetic reporter
Khor, J. M.; Cisneros, I.; Marvel, M.; Gore, A. V.; Taimatsu, K.; Margolin, G.; Castranova, D.; Goldstein, A.; Dale, R.; Weinstein, B. M.
10.1101/2025.04.21.649771 — genomics — Posted on 2025-04-22
1661 Insulated Outlier Chromosomes Drive Metabolic and Evolutionary Innovation in Minimal Eukaryotic Algae
Valiadi, M.; Harrison, K.; Loe-Mie, Y.; Williams, B. A. P.; Ankrett, D.; Smirnoff, N.; Monier, A.
10.1101/2025.04.21.649811 — evolutionary biology — Posted on 2025-04-22
1662 Populus VariantDB v3.2 facilitates CRISPR and Functional Genomics Research
Zhou, R.; Seth, S. R.; Reeves, J.; Burns, A. H.; Hsieh, C.; Horn, T.; Xue, L.-J.; Tsai, C.-J.
10.1101/2025.04.20.649720 — plant biology — Posted on 2025-04-22
1663 Complex structural variant visualization with SVTopo
Belyeu, J. R.; Rowell, W. J.; Lake, J. A.; Holt, J. M.; Kronenberg, Z.; Saunders, C. T.; Eberle, M. A.
10.1101/2025.04.16.649185 — bioinformatics — Posted on 2025-04-22
1665 Deciphering the role of histone modifications in memory and exhausted CD8 T cells
Huang, H.; Baxter, A. E.; Zhang, Z.; Good, C. R.; Alexander, K. A.; Chen, Z.; Garcia, P. A. A.; Samareh, P.; Collins, S. M.; Glastad, K. M.; Wang, L.; Donahue, G.; Manne, S.; Giles, J. R.; Shi, J.; Berger, S. L.; Wherry, E. J.
10.1101/2025.04.16.649198 — immunology — Posted on 2025-04-22
1666 HIV IMPAIRS AND EXPLOITS PULMONARY TH17 AND TH22 CELL-MEDIATED IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS
Martinez-Martinez, Y. B.; Huante, M. B.; Naqvi, K. F.; Shah, M. N.; Lisinicchia, J. G.; Files, M. A.; Perez, J.; Gelman, B. B.; Endsley, M. A.; Endsley, J. J.
10.1101/2025.04.16.649152 — immunology — Posted on 2025-04-22
1667 Glia phagocytose neuronal sphingolipids to infiltrate developing synapses
Theisen, E. K.; Rivas-Serna, I. M.; Lee, R. J.; Jay, T. R.; Kunduri, G.; Nguyen, T. T.; Mazurak, V.; Clandinin, M. T.; Clandinin, T. R.; Vaughen, J. P.
10.1101/2025.04.14.648777 — neuroscience — Posted on 2025-04-22
1673 Leaf shape modulates climate trait relationships in the wild species Chenopodium hircinum (Amaranthaceae)
Rodriguez, J.; Quipildor, V.; Giamminola, E.; Bramardi, S.; Jarvis, D.; Maughan, J.; Xu, J.; Farooq, H.; Ortega-Baes, P.; Jellen, E.; Tester, M.; Bertero, D.; Curti, R. N.
10.1101/2025.04.21.649804 — plant biology — Posted on 2025-04-22
1674 High throughput screen of NPQ in sorghum shows highly polygenic architecture of photoprotection
Vath, R. L.; Fernandes, S.; Monier, B.; Glowacka, K.; Walter, J.; Lipka, A. E.; Ferguson, J. N.; Bernacchi, C.; Pederson, T.; Kromdijk, J.
10.1101/2025.04.18.649521 — plant biology — Posted on 2025-04-22
1676 Evaluating tree biomass estimation in trans-Atlantic mangrove species: comparing bole diameter measurements for improved accuracy
Price, C.; Schroeder, T. A.; Branoff, B.; Marcano-Vega, H.; Pillot-Torres, N.; Chaudry, M.; Ross, M.; Papes, M.; Van Bloem, S.
10.1101/2025.04.19.649682 — plant biology — Posted on 2025-04-22
1677 Five seasons with DeepRootLab: A unique facility for easier deep root research in the field
Han, E.; Clement, C.; Czaban, W.; Smith, A. G.; Dresboll, D. B.; Thorup-Kristensen, K.
10.1101/2025.04.20.649645 — plant biology — Posted on 2025-04-22
1679 Glucosylation of Endogenous Haustorium-inducing factors Underpins Kin Avoidance in Parasitic Plants
Xiang, L.; Cui, S.; Saucet, S. B.; Takahashi, M.; Inaba, S.; Xie, B.; Schilder, M.; Shimada, S.; Cui, M.; Watanabe, M.; Tobimatsu, Y.; Bouwmeester, H.; Tohge, T.; Shirasu, K.; Yoshida, S.
10.1101/2025.04.17.649457 — plant biology — Posted on 2025-04-22
1681 Loss-of-Function RUP-Variants Influence Ubiquitin-Proteasome System and Enhance Carotenoid and Folate Levels in Tomato
Charakana, C.; Gupta, S. K.; Sunkum, A.; Valluri, S.; Bagri, J.; Tyagi, K.; Kumar, R.; Salava, H.; Kilambi, H. V.; Sivapuram, V.; Sharma, R.; Sreelakshmi, Y.
10.1101/2025.04.17.649262 — plant biology — Posted on 2025-04-22
1684 High-resolution genome and genetic map of tetraploid Allium porrum expose pericentromeric recombination
Nieuwenhuis, R.; Voorrips, R.; Esselink, D.; Hesselink, T.; Schijlen, E.; Arens, P.; Cordewener, J.; Scholten, O.; Peters, S.
10.1101/2025.04.21.649809 — plant biology — Posted on 2025-04-22
1685 ERF transcription factor regulons underpin growth-defence trade-off under acute heat stress in rice seedlings
Nair, A. U.; Vishwakarma, S.; Guha, T.; Kadumuri, R. V.; Fritschi, F. B.; Chavali, S.; Allu, A. D.
10.1101/2025.04.21.649784 — plant biology — Posted on 2025-04-22
1686 A citrullination-ubiquitination pathway controls pre-meiotic H1 eviction and is essential for gametogenesis in Arabidopsis
Li, Y.; Fei, D.; Schubert, J.; Rutowicz, K.; Kaczmarska, Z.; Linares, A.; Giraldo-Fonseca, A.; Bischof, S.; Grossniklaus, U.; Baroux, C.
10.1101/2025.04.18.649492 — plant biology — Posted on 2025-04-22
1687 Population analysis and immunologic landscape of melanoma in people living with HIV
Barger, L. N.; Wang, D.; Saravia, A.; Mezzano, V.; Ward, G.; Loomis, C.; Feldman, C.; Tuluc, M.; Seedor, R. S.; Gaskill, P. J.; Coghill, A. E.; Suneja, G.; Dehzangi, I.; Hope, J. L.; Romano, G.
10.1101/2025.04.17.648995 — cancer biology — Posted on 2025-04-22
1688 Unmapped reads from whole-genome sequencing data reveal pathogen diversity in European and African cattle breeds
Ruvinskiy, D.; Pokharel, K.; Okwasiimire, R.; Gonzales-Prendez, R.; Ginja, C.; Ghanem, N.; Kugonza, D. R.; Makgahlela, M. L.; Lindeberg, H.; Weldenegodguad, M.; Kantanen, J.; Derks, M.; Croojmans, R. P. M. A.
10.1101/2025.04.17.649267 — bioinformatics — Posted on 2025-04-22
1692 Benchmarking long-read genome assemblers for three sequencing protocols and three agricultural species
Birbes, C.; Dreau, A.; Milan, D.; Iampietro, C.; Gaspin, C.; Donnadieu, C.; Zytnicki, M.; Klopp, C.
10.1101/2025.02.14.638238 — bioinformatics — Posted on 2025-04-22
1693 High quality genome assemblies of African cattle breeds using PacBio HiFi sequencing
Houaga, I.; Bhati, M.; Nziku, Z.; Nguluma, A.; Mapholi, N.; Nesengani, L. T.; Ogugo, M.; Sagbo, D. C. Y.; Zorobouragui, L.; Boco, M. B. Y.; Djikeng, A.; Prendergast, J. G. D.; Gorjanc, G.; Becher, H.
10.1101/2025.04.17.649430 — genomics — Posted on 2025-04-22
1694 Angel Wing: a class of alternative splicing regulators in animals
Zhang, T.; Li, K.; Ying, X.; Tan, X.; Tan, X.; Cui, M.; Rong, Y. S.
10.1101/2025.04.20.649734 — genetics — Posted on 2025-04-22
1697 PyReconstruct: A fully opensource, collaborative successor to Reconstruct
Chirillo, M. A.; Falco, J. N.; Musslewhite, M. D.; Lindsey, L. F.; Harris, K. M.
10.1101/2025.04.21.649793 — cell biology — Posted on 2025-04-22
1707 Cognitive Mode Detectable with Task-Based fMRI: Default Mode B (DMB)
Ni, Y. Q. Y.; Redway, S.; Momeni, A.; Momeni, A.; Jian, L.; Yip, L.; Woodward, T. S.
10.1101/2025.04.21.649745 — neuroscience — Posted on 2025-04-22
1708 Single Cell Landscape of Sex-specific Drivers of Alzheimers Disease
Wu, Y.; Travaglini, K. J.; Gabitto, M.; Keene, D.; Dunn, A.; Kaczorowski, C.; Harari, O.; De Jager, P.; Menon, V.; Schneider, J. A.; Bennett, D. A.; Dumitrescu, L.; Hohman, T. J.
10.1101/2025.04.18.647076 — neuroscience — Posted on 2025-04-22
1713 A multicellular actin star network underpins epithelial organization and connectivity
Barai, A.; Soleilhac, M.; Xi, W.; Lin, S.-Z.; Karnat, M.; Bazellieres, E.; Richelme, S.; Lecouffe, B.; Chardes, C.; Berrebi, D.; Ruemmele, F.; Thery, M.; Rupprecht, J.-F.; Delacour, D.
10.1101/2024.07.26.605277 — cell biology — Posted on 2025-04-22
1714 High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Imai, S.; Hario, S.; Suerte, C.; Yamaguchi, I.; Sakoi, K.; Terai, T.; Takahashi-Yamashiro, K.; Campbell, R. E.
10.1101/2025.04.17.649293 — molecular biology — Posted on 2025-04-21
1715 Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria
Zhang, L.; Guan, Y.; Cheng, Y. Y.; Cokcetin, N. N.; Bottomley, A.; Robinson, A.; Harry, E.; van Oijen, A. M.; Su, Q. P.; Jin, D.
10.1101/2022.03.29.486198 — microbiology — Posted on 2025-04-21
1723 Human Papilloma Virus does not fully inactivate p53 cellular activity in HNSCC
Gencel-Augusto, J.; Li, H.; Woerner, L. C.; Borah, A. A.; Myers, J. N.; Ha, P.; Johnson, D. E.; Grandis, J. R.
10.1101/2025.02.11.637252 — cancer biology — Posted on 2025-04-21
1726 Bioprinting of Human Primary and iPSC-derived Islets with Retained and Comparable Functionality
Poklar, M.; K, R.; Wiegand, C.; Mizerak, B.; Wang, R.; Florentino, R. M.; Liu, Z.; Soto-Gutierrez, A.; Kumta, P. N.; Banerjee, I.
10.1101/2024.10.14.617656 — bioengineering — Posted on 2025-04-21
1733 SeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniae
Lorenz, O.; King, A. C.; Hung, H. C. H.; Ganaie, F. A.; Wyllie, A. L.; Manna, S.; Satzke, C.; van der Linden, M.; Ravenscroft, N.; Slotved, H.-C.; McGee, L.; Nahm, M. H.; Bentley, S. D.; Lo, S. W.
10.1101/2025.04.16.648953 — bioinformatics — Posted on 2025-04-21
1740 Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states.
Marin-Arraiza, L.; Roa-Eguiara, A.; Pape, T.; Sofos, N.; Hendriks, I. A.; Lund Nielsen, M.; Steiner-Rebrova, E. M.; Taylor, N. M. I.
10.1101/2025.04.20.649488 — molecular biology — Posted on 2025-04-21
1741 RIP2 inhibits DOCK8-mediated platelet dense granule release and alleviates experimental myocardial infarction
Zhang, J.; Zhang, Z.; Pan, G.; Liu, Y.; Chang, L.; Qi, Z.; Zhang, Y.; Zhang, S.; Qiao, J.; Xi, X.; Dai, K.; Dong, J.; Ding, Z.
10.1101/2025.04.19.649674 — molecular biology — Posted on 2025-04-21
1742 Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections
Lou, Y.; Zhang, B.; Zhang, Z.; Pan, Y.; Yang, J.; Li, L.; Huang, J.; Yuan, Z.; Liegeois, S.; Bulet, P.; Xu, R.; Li, Z.; FERRANDON, D.
10.1101/2025.04.16.649162 — immunology — Posted on 2025-04-21
1743 Aicardi-Goutieres Syndrome Associated ADAR G1007R mutation dominantly induces neuroinflammation in mouse brain
Guo, X.; Liu, J.-J.; Shang, C.; Guerriero, C.; Wiley, C.; Steinman, R.; Sheng, Y.; Brodsky, J.; Billiar, T.; Liu, S.; Wang, Q.
10.1101/2025.04.21.649787 — neuroscience — Posted on 2025-04-21
1746 Automated Bacteriophage Evolution Studies with the Aionostat
Druelle, V.; Molari, M.; Castagnetti, G.; Harms, A.; Neher, R. A.
10.1101/2025.04.16.649189 — evolutionary biology — Posted on 2025-04-21
1747 Greater Expression of DNA Repair Pathways in Sharks vs. Rays/Skates Based on Transcriptomic Analyses
Simmons, C. R.; Grant, S. L.; Llorente Ruiz, L.; Kerstetter, D. W.; Pimpley, M.; Latimer, J. J.
10.1101/2025.04.20.649719 — molecular biology — Posted on 2025-04-21
1748 Evaluation of nanopore sequencing for increasing accessibility of eDNA studies in biodiverse countries
Gygax, D.; Urban, L.; Ramirez, S.; Chibesa, M.; Simpamba, T.; Riffel, M.; Riffel, T.; Srivathsan, A.; Nijland, R.
10.1101/2025.04.21.649756 — molecular biology — Posted on 2025-04-21
1749 Spatial and Temporal Patterns of Public Transit Aerobiomes
Orr, R. J.; Brynildsrud, O.; Boifot, K. O.; Gohli, J.; Skogan, G.; Kelly, F. J.; Hernandez, M. T.; Udekwu, K.; Lee, P. K.; Mason, C.; Dybwad, M.
10.1101/2025.04.21.649744 — microbiology — Posted on 2025-04-21
1750 Nucleoid Compaction Influences Carboxysome Localization and Dynamics in Synechococcus elongatus PCC 7942
Dudley, C. E.; Azaldegui, C. A.; Foust, D.; LaCommare, O.; Biteen, J. S.; Vecchiarelli, A. G.
10.1101/2025.04.21.649805 — microbiology — Posted on 2025-04-21
1753 The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies.
Ferreira, R.; Hannan, K. M.; Panov, K.; Udumanne, T.; George, A. J.; Closa, A.; Yuen, Z.; Eyras, E.; Poh, P.; Maclachlan, K.; Dwyer, M.; Barn, V.; He, J.; Kusnadi, E.; Rebello, R.; Huglo, A.; Hedwards, S.; Lawrence, M.; Risbridger, G.; Taylor, R.; Clark, A.; Farrell, G.; Pok, S.; Teoh, N.; Amarasini, M.; Norcott, P. L.; Banwell, M. G.; Manenkova, Y.; Haddach, M.; Drygin, D.; Furic, L.; Hannan, R. D.; Hein, N.
10.1101/2025.04.19.649466 — cancer biology — Posted on 2025-04-21
1756 ANARCII: A Generalised Language Model for Antigen Receptor Numbering
Greenshields-Watson, A.; Agarwal, P.; Robinson, S. A.; Williams, B. H.; Gordon, G. L.; Capel, H. L.; Li, Y.; Spoendlin, F. C.; Boyles, F.; Deane, C. M.
10.1101/2025.04.16.648720 — bioinformatics — Posted on 2025-04-21
1758 The oral cavity of chronically homeless adults is home for unusual extremophile environmental bacteria
Ruiz-Coronel, A.; Sandoval-Motta, S.; Melendez-Sanchez, D.; Larios-Serrato, V.; Torres, R. C.; Torres, J.
10.1101/2025.04.16.649188 — bioinformatics — Posted on 2025-04-21
1759 Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot
Zhu, L.; Nguyen, L. T.; Bell, A. G.; Gillmann, K. M.; Oatman, H.; Hariri, J.; Myhrvold, C. E.; Toettcher, J. E.
10.1101/2025.04.21.649818 — bioengineering — Posted on 2025-04-21
1760 Discovery of a wide variety of α-1,6-cyclized β-1,2-glucan synthases: a new entrance for host-microbe interactions.
Motouchi, S.; Kim, I.; Ishiguro, A.; Niu, K.; Komba, S.; Kashima, T.; Kitano, Y.; Nakai, H.; Nakajima, M.
10.1101/2025.04.21.649730 — biochemistry — Posted on 2025-04-21
1761 Pollen sterols are highly diverse but phylogenetically conserved
Baker, E.; Lamborn, E.; Quinonez, J.; karlsdottir, s.; Shepard, A.; Moore, E.; Kunin, B.; Wright, G.; Stevenson, P.
10.1101/2025.04.21.649781 — biochemistry — Posted on 2025-04-21
1762 Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brain
Zeng, Q.; Tian, W.; Klein, A.; Bartlett, A.; Liu, H.; Nery, J. R.; Castanon, R. G.; Osteen, J.; Johnson, N.; Wang, W.; Ding, W.; Chen, H.; Altshul, J.; Kenworthy, M.; Valadon, C.; Owens, W.; Wu, Z.; Amaral, M. L.; Song, Y.; Baez-Becerra, C. T.; Cho, S.; Chen, C.; Willier, J.; Cao, S.; Rink, J.; Lee, J.; Barcoma, A.; Arzavala, J.; Emerson, N.; Lu, Y. R.; Ren, B.; Behrens, M. M.; Ecker, J. R.
10.1101/2025.04.21.648266 — genomics — Posted on 2025-04-21
1767 Accelerated evolution of whole gene clusters by an engineered lytic phage system in E. coli
Ong, S.; Ghode, P.; Narenderan, A.; Willenborg, F.; Eden, T. V.; Lao, S.; Marsh, C. O.; Yew, W. S.; Fredens, J.
10.1101/2025.04.21.649713 — synthetic biology — Posted on 2025-04-21
1769 A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity
Jaiswal, A. K.; Scherer, G. M.; Thaxton, M. L.; Sorrentino, J. P.; Yuen, C.; Mehta, M. M.; Sharma, G.; Lin, T. L.; Tran, T. M.; Cohen, A.; Ritter, A. J.; Kotecha, R. S.; Sanford, J. R.; Damoiseaux, R. D.; Garg, N. K.; Rao, D. S.
10.1101/2025.04.14.648780 — cancer biology — Posted on 2025-04-21
1770 Inferring tumour microenvironment ecosystems from scRNA-seq atlases
Yu, C.; Geuenich, M. J.; Ge, S.; Jang, G.-H.; Ju, T. T.; Zhang, A.; O'Kane, G.; Notta, F.; Campbell, K. R.
10.1101/2024.08.21.608956 — bioinformatics — Posted on 2025-04-21
1772 Obesity promotes urinary tract infection by disrupting urothelial immune defenses
Schwartz, L.; Salamon, K.; Simoni, A.; Cotzomi-Ortega, I.; Sanchez-Zomora, Y.; Linn-Peirano, S.; John, P.; Ruiz-Rosado, J. d. D.; Jackson, A. R.; Wang, X.; Spencer, J. D.
10.1101/2025.04.04.647270 — cell biology — Posted on 2025-04-21
1773 Transient SUMOylation Inhibition Induces Stable Epigenetic Beiging Fate In Human White Adipocytes
Nothnagel, P. M.; Briand, N.; Wik, J. A.; Strom, Y. E.; Bjoras, M.; Enserink, J. M.; Skalhegg, B. S.; Mathelier, A.; Chymkowitch, P.
10.1101/2025.03.07.642034 — molecular biology — Posted on 2025-04-21
1774 Mechanisms of AAV neutralization by human alpha-defensins
Porter, J. M.; Hulce, K. R.; Oswald, M. S.; Busuttil, K.; Emmanuel, S. N.; Bennett, A.; McKenna, R.; Smith, J. G.
10.1101/2024.09.25.614754 — microbiology — Posted on 2025-04-21
1775 Oral Administration of Boldine Reduces Spare Nerve Injury-Induced Neuropathic Pain
Pan, J.; Toro, C. A.; Chow, C.; Duarte, Y.; Saez, J. C.; Cardozo, C. P.; Zhao, W.
10.1101/2024.11.05.622128 — neuroscience — Posted on 2025-04-21
1777 The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer
Liu, H.; Yu, L.; Majerciak, V.; Meyer, T.; Yi, M.; Johnson, P. F.; Cam, M.; Lowy, D. R.; Zheng, Z.-M.
10.1101/2024.02.01.578320 — cancer biology — Posted on 2025-04-21
1778 SORBET: Automated cell-neighborhood analysis of spatial transcriptomics or proteomics for interpretable sample classification via GNN
Shimonov, S.; Cunningham, J.; Talmon, R.; Aizenbud, L.; Desai, S.; Rimm, D.; Schalper, K.; Kluger, H.; Kluger, Y.
10.1101/2023.12.30.573739 — bioinformatics — Posted on 2025-04-21
1779 One-step generation of modified cattle and sheep from spermatid-like haploid stem cells
Yang, L.; Di, A.; Song, L.; Liu, X.; Wu, D.; Wang, S.; Hao, Z.; Bu, L.; Bai, C.; Su, G.; Wei, Z.; Zhang, L.; Liu, Z.; Gao, S.; Li, G.
10.1101/2024.09.10.612264 — bioengineering — Posted on 2025-04-21
1781 Effects of urbanization on the microbial fungal communities from water, sediment, and amphibian hosts across a rural-to-urban waterway in Worcester, Massachusetts
Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.
10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-21
1782 Robust coexistence in ecological competitive communities
Lechon-Alonso, P.; Kundu, S.; Lemos-Costa, P.; Capitan, J. A.; Allesina, S.
10.1101/2024.07.10.602979 — ecology — Posted on 2025-04-21
1783 The condensate-forming protein eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage
Bhatia, P.; Tafur, J.; Amin, R.; Familiari, N. E.; Yaguchi, K.; Tran, V. M.; Bond, A.; Bukulmez, O.; Woodruff, J. B.
10.1101/2024.10.29.620718 — developmental biology — Posted on 2025-04-21
1785 Functionally Adaptive Structural Basis Sets of the Brain: A Dynamic Fusion Approach
Duda, M.; Chen, J.; Belger, A.; Ford, J.; Mathalon, D.; Preda, A.; Turner, J. A.; Van Erp, T.; Pearlson, G. D.; Calhoun, V.
10.1101/2024.06.18.599621 — neuroscience — Posted on 2025-04-21
1786 Speech markers of psychedelic-induced psychological change
Kuc, J.; McAlpine, R. G.; Sellers, A.; Blackburne, G.; Lametti, D. R.; Skipper, J. I.
10.1101/2025.04.16.649217 — neuroscience — Posted on 2025-04-21
1787 The Dual Molecular Identity of Vestibular Kinocilia: Bridging Structural and Functional Traits of Primary and Motile Cilia
Xu, Z.; Tavakoli, A.; Kulasooriya, S.; Liu, H.; Tu, S.; Bloom, C.; Li, Y.; Zuo, J.; Tao, L.; Kachar, B.; He, D. Z. Z.
10.1101/2025.04.16.647417 — neuroscience — Posted on 2025-04-21
1788 Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8+ T cell exhaustion
Wang, H.; Wei, H.; Gou, W.; Kim, J.; Subramanian, S.; Yeung, T.; Chakraborty, P.; Mehrotra, S.; Berto, S.; Strange, C.
10.1101/2025.04.19.649667 — cell biology — Posted on 2025-04-21
1790 Constitutive cGAS-STING activation in ALT+ cells
Geelen, D.; Beacom, A.; Vaurs, M.; Mahieu, M.; Boutoual, R.; Derumier, A.; Hoerr, R.; Loriot, A.; Nassour, J.; Decottignies, A.
10.1101/2025.04.18.649516 — cell biology — Posted on 2025-04-21
1792 Cell cycle control of cohesion establishment
Rankin, B. D.; Moore, V.; Flavors, D.; Rankin, S.
10.1101/2025.04.18.649605 — cell biology — Posted on 2025-04-21
1794 FilaBuster: A Strategy for Rapid, Specific, and Spatiotemporally Controlled Intermediate Filament Disassembly
Moore, A. S.; Krug, T.; Hansen, S. B.; Ludlow, A. V.; Grimm, J. B.; Ayala, A. X.; Plutkis, S. E.; Wang, N.; Goldman, R. D.; Medalia, O.; Lavis, L. D.; Weitz, D. A.; Lippincott-Schwartz, J.
10.1101/2025.04.20.649718 — cell biology — Posted on 2025-04-21
1795 Mechanism of USP21 autoinhibition and histone H2AK119 deubiquitination
Rahman, S.; Morgan, M. T.; Hicks, C. W.; Gwizdala, A.; Wolberger, C.
10.1101/2025.04.17.649347 — biophysics — Posted on 2025-04-21
1796 Rare codon translation regulates growth factor-dependent cell proliferation
Ma, Y.; Pronovost, S. M.; Lewis, M. R.; Scherzer, M. T.; Shen, J.; Edgar, B. A.
10.1101/2025.04.17.648825 — cell biology — Posted on 2025-04-21
1798 Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skin.
Wang, D.; Wang, Z.; Yang, Y.; Bai, F.; Li, H.; He, J.; Zhou, F.; Chen, T.; Fang, T.; Wu, Z.; Zhong, J.; Xiang, L.; Man, Y.; Wu, Y.
10.1101/2025.04.17.648896 — cell biology — Posted on 2025-04-21
1802 A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P2 Lipids, Protecting Them from Hydrolysis
Beiter, J.; Sung, C.-J.; Lin, S.-S.; DeVuono, N.; Arumugam, S.; Manzi, J.; Bertin, A.; Bassereau, P.; Liu, Y.-W.; Voth, G. A.; Tsai, F.-C.
10.1101/2025.03.26.645564 — biophysics — Posted on 2025-04-21
1803 Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli
Vystrcilova, M.; Sridhar, S.; Burg, M. F.; Khani, M. H.; Karamanlis, D.; Schreyer, H. M.; Ramakrishna, V.; Krüppel, S.; Zapp, S. J.; Mietsch, M.; Gollisch, T.; Ecker, A. S.
10.1101/2025.04.09.647910 — systems biology — Posted on 2025-04-21
1804 A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights
Cha, J. H.; Kim, N.; Ma, J.; Lee, S.; Koh, G.; Yang, S.; Beck, S.; Byeon, I.; Lee, B.; Lee, I.
10.1101/2025.03.10.642329 — microbiology — Posted on 2025-04-21
1805 Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue.
Nelli, R. K.; Harm, T. A.; Arruda, B.; Siepker, C.; Fasina, O.; Groeltz, J.; Baker, A.; Phillips, R.; Jones, B.; Espina, V.; Seger, H.; Plummer, P.; Bell, T.
10.1101/2025.04.16.649193 — immunology — Posted on 2025-04-21
1807 Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study
Maki-Marttunen, V.; Nerland, S.; Jorgensen, K.; Hogestol, E.; Rokicki, J.; Alnaes, D.; Borgwardt, S.; Boye, B.; Buitelaar, J.; Boen, E.; Cervenka, S.; Conzelmann, A.; Erhardt, S.; Franke, B.; Celius, E.; Harbo, H.; Hilland, E.; Hoekstra, P.; Hartman, C.; Jonassen, R.; Jonsson, E.; Landro, N.; Lesch, K.-P.; Maglanic, L.; Pauli, P.; Sellgren, C.; Nygaard, G.; Oosterlaan, J.; Schmidt, A.; Schwarz, E.; Ziegler, G.; Agartz, I.; Westlye, L.; Andreassen, O.; Kaufmann, T.; Elvsashagen, T.
10.1101/2025.04.21.649628 — neuroscience — Posted on 2025-04-21
1809 NOX4 prevents the recruitment of PAX8 and NKX2.1 to chromatin in BRAF-mutated thyroid cancer cells.
Radom, M.; Buffet, C.; Cazarin, J.; Harinquet, M.; Coelho de Faria, C.; Braye, F.; Nobre, C.; Aglave, M.; Mesloub, Y.; Dayris, T.; DROIN, N.; Godefroy, K.; Bani, M.-A.; Al Ghuzlan, A.; Leboulleux, S.; Lamartina, L.; DUPUY, C.
10.1101/2025.04.14.647724 — cancer biology — Posted on 2025-04-21
1811 Evolution of the cellular landscape in mammalian striatum
Buyukkahraman, G.; Caglayan, E.; Hoerpel, S. G.; Zhang, Y.; van Tussenbroek, I. A.; Orozco, C. G.; Oh, E.; Hopkins, W. D.; Sherwood, C. C.; Roberts, T. F.; Vernes, S. C.; Konopka, G.
10.1101/2025.04.20.649707 — genomics — Posted on 2025-04-21
1812 Multiple human enhancer RNAs contain long translated open reading frames
Vlasov, P. A.; Ogami, K.; Valenzuela, E.; Kawaguchi, R. K.; Jovanovic, M.; Manley, J. L.
10.1101/2025.04.18.649583 — molecular biology — Posted on 2025-04-21
1813 Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus
Yeh, T.-Y.; Tsai, V.; Liao, S. M.; Hong, C.-E.; Kuo, F.-Y.; Wang, Y. C.; Feehley, M. C.; Feehley, P. J.; Lai, Y.-C.; Contreras, G. P.
10.1101/2025.04.17.649446 — microbiology — Posted on 2025-04-21
1816 Kinocilia of Vestibular Hair Cells: Bridging Structural and Functional Traits of Primary and Motile Cilia
Xu, Z.; Tavakoli, A.; Kulasooriya, S.; Liu, H.; Tu, S.; Bloom, C.; Li, Y.; Zuo, J.; Tao, L.; Kachar, B.; He, D. Z. Z.
10.1101/2025.04.16.647417 — neuroscience — Posted on 2025-04-21
1817 Unsupervised feature computation-based feature selection robustly extracted resting-state functional connectivity patterns related to mental disorders
Yamashita, A.; Itahashi, T.; Sakai, Y.; Takamura, M.; Togo, H.; Yoshihara, Y.; Okada, T.; Yamagata, H.; Harada, K.; Takagishi, H.; Hosomi, K.; Okada, N.; Abe, O.; Okada, G.; Okamoto, Y.; Hashimoto, R.; Hanakawa, T.; Murai, T.; Matsuo, K.; Takahashi, H.; Kasai, K.; Hayashi, T.; Koike, S.; Tanaka, S. C.; Kawato, M.; Imamizu, H.; Yamahshita, O.; Brain/MINDS Beyond Human Brain MRI Group,
10.1101/2025.04.14.648842 — neuroscience — Posted on 2025-04-21
1818 HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against hypoxia-induced neuronal injury
Li, Y.; Guo, M.; Tian, Z.; Shao, Q.; Liu, Y.; Gu, Y.; Xu, Z.; Jin, F.; Ji, X.; Liu, J.
10.1101/2025.04.16.649120 — neuroscience — Posted on 2025-04-21
1819 Arcuate Fasciculus: Evolutionary Convergence in Marmosets and Humans
Wang, Y.; Cheng, L.; Li, D.; Lu, Y.; Hopkins, W.; Sherwood, C.; Xu, T.; Liu, C.; Paxinos, G.; Jiang, T.; Chu, C.; Fan, L.
10.1101/2025.04.21.649746 — neuroscience — Posted on 2025-04-21
1820 ER fusogens maintain membrane reservoir to ensure brain function
Miao, H.; Wang, Y.; Huang, Y.; Zhang, H.; Zheng, L.; Zhou, X.; Wang, X.; Xie, Q.; Xue, L.; Hu, J.
10.1101/2025.04.12.648519 — neuroscience — Posted on 2025-04-21
1821 CERIUM OXIDE NANOPARTICLES ATTENUATE THE PRO-ARRHYTHMIC EFFECT OF DIESEL EXHAUST PARTICLES IN ISOLATED RAT HEARTS BY REDUCING OXIDATIVE STRESS.
Ganse, F. G.; Ernst, L. M.; Rodriguez, C.; Ruiz-Meana, M.; Inserte, J.; Martinez-Gonzalez, J.; Briones, A. M.; Garcia-Redondo, A. B.; Consegal, M.; Miro-Casas, E.; Yanez-Bisbe, L.; Pomposo, A.; Prades-Martinez, M.; Ferreira-Gonzalez, I.; Puntes, V.; Benito, B.; Rodriguez-Sinovas, A.
10.1101/2025.04.11.648481 — pharmacology and toxicology — Posted on 2025-04-21
1826 IL-17 sensitises sensory neurons and colonic afferents to noxious stimuli in a PI3K dependent manner
Paine, L. W.; Higham, J. P.; Barker, K. H.; Pavlou, S.; Welsh, F.; Smith, E. S. J.; Bulmer, D.
10.1101/2025.04.16.649143 — neuroscience — Posted on 2025-04-21
1830 Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study
Maki-Marttunen, V.; Nerland, S.; Jorgensen, K.; Hogestol, E.; Rokicki, J.; Alnaes, D.; Borgwardt, S.; Boye, B.; Buitelaar, J.; Boen, E.; Cervenka, S.; Conzelmann, A.; Erhardt, S.; Franke, B.; Celius, E.; Harbo, H.; Hilland, E.; Hoekstra, P.; Hartman, C.; Jonassen, R.; Jonsson, E.; Landro, N.; Lesch, K.-P.; Maglanic, L.; Pauli, P.; Sellgren, C.; Nygaard, G.; Oosterlaan, J.; Schmidt, A.; Schwarz, E.; Ziegler, G.; Agartz, I.; Westlye, L.; Andreassen, O.; Kaufmann, T.; Elvsashagen, T.
10.1101/2025.04.21.649628 — neuroscience — Posted on 2025-04-21
1831 Identification of MARVELlous Protein Markers for Phytophthora infestans Extracellular Vesicles
Breen, S.; McLellan, H.; Wang, W.; Wang, S.; Welsh, L.; Pham, J.; Whisson (SW), s.; Boevink, P.; Birch, P. R.
10.1101/2025.04.11.648357 — plant biology — Posted on 2025-04-21
1832 Omics-driven Identification of Candidate Genes and SNP markers in a Major QTL Controlling Early Heading in Rice
Rao, D.; T, N. S.; CG, G.; Gaur, N.; Jamaloddin, M.; Maganti, S. M.; Raman, M. S.; Patel, H. K.; Tiwari, S.; Sonti, R. V.
10.1101/2025.03.25.645207 — plant biology — Posted on 2025-04-21
1834 GPU-accelerated homology search with MMseqs2
Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.
10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-04-21
1837 Heritability of human lifespan is about 50% when confounding factors are addressed
Shenhar, B.; Pridham, G.; de Oliveira, T. L.; Yang, Y.; Raz, N.; Deelen, J.; Hagg, S.; Alon, U.
10.1101/2025.04.20.649385 — genetics — Posted on 2025-04-21
1840 WITHDRAWN: GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research
Ingle, O. K.; Melville, L.; Beechener, S.; Hardy, C.; Howell, A.; Hobbs, N. P.; Mahon, N.; Morgan, E. R.; Bartley, D.; Rose Vineer, H.
10.1101/2025.02.21.639461 — ecology — Posted on 2025-04-21
1842 Human CCR4 deadenylase homolog Angel1 is a Non-Stop mRNA Decay factor
Nicholson-Shaw, T.; Dowdle, M. E.; Ajaj, Y.; Perelis, M.; Fulzele, A.; Yeo, G. W.; Bennett, E. J.; Lykke-Anderson, J.
10.1101/2022.04.28.489582 — molecular biology — Posted on 2025-04-21
1843 Identification of ambisense kolmioviruses
Kishimoto, M.; Imai, S.; Igarashi, M.; Horie, M.
10.1101/2025.01.08.631871 — microbiology — Posted on 2025-04-21
1844 CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis
Fu, L.; Yin, C.; Zhao, Q.; Guo, S.; Shao, W.; Xia, T.; Sun, Q.; Chen, L.; Li, J.; Wang, M.; Xia, H.
10.1101/2024.02.21.581332 — immunology — Posted on 2025-04-21
1845 JAK inhibitors remove innate immune barriers facilitating viral propagation
Ravlo, E.; Ianevski, A.; Skipperstoen, M.; Lysvand, H.; Schjolberg, J.-O.; Solheim, O. S.; Wang, W.; Kissova, M.; Vestrik, M.; Vapalahti, O.; Smura, T.; Vauhkonen, H.; Oksenych, V.; Weber, F.; Strand, M.; Evander, M.; Malmring, J.; Afset, J. E.; Bjoras, M.; Kainov, D. E.
10.1101/2025.02.17.638720 — immunology — Posted on 2025-04-21
1847 Suite3D: Volumetric cell detection for two-photon microscopy
Haydaroglu, A.; Chang, T.; Landau, A.; Krumin, M.; Dodgson, S.; Baruchin, L. J.; Cozan, M.; Guo, J.; Meyer, D.; Reddy, C. B.; Zhong, J.; Ji, N.; Schröder, S.; Harris, K. D.; Vaziri, A.; Carandini, M.
10.1101/2025.03.26.645628 — neuroscience — Posted on 2025-04-21
1851 The autophagy-related genes AtATG5 and AtATG7 influence reserve mobilisation and responses to ABA during seed germination in Arabidopsis thaliana
Contreras, E.; Sanchez-Vicente, I.; Pastor-Mora, E.; Aylon-Rodriguez, M.; Gonzalez-Ceballos, M.; Delgado-Gutierrez, M. A.; Lorenzo, O.; Vicente-Carbajosa, J.; Iglesias-Fernandez, R.
10.1101/2024.05.15.593177 — plant biology — Posted on 2025-04-21
1852 Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc
He, J.; Huang, S.; Li, Y.; Wang, Y.; Yan, P.; Hu, O.; Lin, P.; Jin, H.; Zhu, J.; Zhang, L.; Liu, Y.; Qin, Q.; Guo, Y.; Zheng, X.; Xie, Y.; Chen, L.; Lan, Y.; Liu, B.; Liu, P.; Gan, Y.
10.1101/2023.07.24.550303 — physiology — Posted on 2025-04-21
1854 CAMP: A modular metagenomics analysis system for integrated multi-step data exploration
Mak, L.; Tierney, B.; Wei, W.; Ronkowski, C.; Brizola Toscan, R.; Turhan, B.; Toomey, M.; Martinez, J. S. A.; Fu, C.; Lucaci, A. G.; Barrios Solano, A. H.; Setubal, J. C.; Henriksen, J. R.; Zimmerman, S.; Kopbayeva, M.; Noyvert, A.; Iwan, Z.; Kar, S.; Nakazawa, N.; Meleshko, D.; Horyslavets, D.; Kantsypa, V.; Frolova, A.; Kahles, A.; Danko, D.; Elhaik, E.; Labaj, P.; Mason, C.; Hajirasouliha, I.
10.1101/2023.04.09.536171 — bioinformatics — Posted on 2025-04-21
1856 miRNA Mimic Optimization: Chemical Structure - Activity - Targetome Relationship to Engineer Selective Anti-Tumor Immunity in T cells
Segarra-Visent, X.; Ryaykenen, T.; Kremer, A.; Sauer, M.; Jackson, S.; Cooper, D. A.; Echeverria, D.; Haraszti, R. A.
10.1101/2025.04.16.649059 — bioengineering — Posted on 2025-04-21
1857 Learning is a fundamental source of behavioral individuality
Manna, R.; Brea, J.; Braga, G. V.; Modirshanechi, A.; Tomic, I.; Jaksic, A. M.
10.1101/2024.08.30.610528 — animal behavior and cognition — Posted on 2025-04-21
1859 Impacts on the microbial fungal communities across water, sediment, and amphibian hosts across an urbanization gradient waterway in Worcester, Massachusetts
Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.
10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-21
1860 Bclaf1 biomolecular condensates protect nuclear PTK2 from ubiquitin-proteasome system promoting cardiomyocyte survival during oxidative stress
Aparecida Moretto, I.; Rodrigues, B. R. I.; Victor-Carvalho, P.; Carvalho, M. d. G. d. S.; Silva, M. C. d.; Valdivieso-Rivera, F. B.; Araujo, G. L. d.; Samogim, A. P.; Novais, L. B.; de Brito, I. R.; Reis-de-Oliveira, G.; Amaral, A. G.; Baratti, M. O.; Basei, F. L.; Geraldo, M. V.; Carvalho, P. C.; Santos, M. D. M.; Duran, R.; Sponton, C.; Kobarg, J.; Gozzo, F. C.; Carvalho, H. F.; Thomaz, A. A. d.; Santos, A. M. d.
10.1101/2025.02.04.636487 — cell biology — Posted on 2025-04-21
1861 Heritability of human lifespan is about 50% when confounding factors are addressed
Shenhar, B.; Pridham, G.; de Oliveira, T. L.; Yang, Y.; Raz, N.; Deelen, J.; Hagg, S.; Alon, U.
10.1101/2025.04.20.649385 — genetics — Posted on 2025-04-21
1864 Evidence for an active handoff between cerebral hemispheres during target tracking
Broschard, M. B.; Roy, J. D.; Brincat, S. L.; Mahnke, M. K.; Miller, E. K.
10.1101/2025.04.18.649553 — neuroscience — Posted on 2025-04-21
1865 Opponent regulation of striatal output pathways by dopamine and serotonin
Pinto, D. F. C.; Guo, M. Y.; Morishita, W.; Pomrenze, M. B.; Eshel, N.; Malenka, R. C.
10.1101/2025.04.17.649431 — neuroscience — Posted on 2025-04-21
1866 How infant brains fold: Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure
Tung, S. S.; Yan, X.; Fascendini, B.; Tyagi, C. G.; Reyes, C. M.; Ducre, K.; Perez, K.; Allen, A.; Horenziak, J.; Wu, H.; Keil, B.; Natu, V. S.; Grill-spector, K.
10.1101/2025.04.18.649604 — neuroscience — Posted on 2025-04-21
1872 Association between Cortical Thickness and Functional Response to Linguistic Processing in the Occipital Cortex of Early Blind Individuals
Czarnecka, M.; Hryniewiecka, K.; Wolna, A.; Baumbach, C.; Beck, J.; Vadlamudi, J.; Collignon, O.; Jednorog, K.; Szwed, M.; Stroh, A.-L.
10.1101/2025.04.17.645592 — neuroscience — Posted on 2025-04-21
1873 Population-level constraints on single neuron tuning changes during behavioral adaptation
Stealey, H. M.; Zhao, Y.; Lu, H.-Y.; Contreras-Hernandez, E.; Chang, Y.-J.; Tobler, P. N.; Lewis-Peacock, J. A.; Santacruz, S. R.
10.1101/2025.04.17.649401 — bioengineering — Posted on 2025-04-21
1874 VN1K: a genome graph-based and function-driven multi-omics and phenomics resource for the Vietnamese population
Tran, T. T. H.; Hoang, T. H.; Tran, M. H.; Nguyen, N. T.; Nguyen, D. T.; Pham, T.; Pham, T. M.; Nguyen, N. N.; Vu, G. M.; Duong, V. C.; Vu, Q. T.; Nguyen, T. K.; Nguyen, T. M.; Vu, H. Q.; Dang, T.; Nguyen, H.; Do, T.; Le, C.; Nguyen, H. T. T.; Le, N. Q.; Le, L. T.; Vu, D. M.; Ngo, T. D.; Le, H. T. T.; Nguyen, L. T.; Ha, T. C.; Hoang, Y.; Dao, D. X.; Giang, P. H.; Luu, H. N.; Dao, M. D.; Le, L.; Le, V. S.; Tran, T.; Nguyen, Q.; Le, D.-H.; Nguyen, D. T.; Vu, V. H.; Vo, N. S.
10.1101/2025.04.15.648991 — genomics — Posted on 2025-04-21
1875 Inferring domestic goat demographic history through ancient genome imputation
Erven, J. A. M.; Etourneau, A.; Mashkour, M.; Neupane, M.; Bardou, P.; Stella, A.; Talenti, A.; Masiga, C. W.; Van Tassel, C. P.; Clark, E. L.; Pompanon, F.; Colli, L.; Amallis, M.; Milanesi, M.; Crepaldi, P.; Consortium, T. V.; Servin, B.; Rosen, B.; Tosser-Klopp, G.; Daly, K. G.
10.1101/2025.04.18.649576 — genomics — Posted on 2025-04-21
1876 alms1 regulates the immune response and brain ageing in zebrafish
Bea-Mascato, B.; Mendez-Martinez, L.; Costas-Prado, C.; Guerrero-Pena, L.; Suarez-Bregua, P.; Rotllant, J.; Valverde, D.
10.1101/2025.04.19.639742 — genomics — Posted on 2025-04-21
1878 Evidence of parental care as a novel reproductive isolating mechanism
Behrens, C.; Maciejewski, M. F.; Sumarli, A.; Lucas, G.; Lagunas-Robles, G.; Samuk, K.; Bell, A. M.
10.1101/2025.04.18.649590 — evolutionary biology — Posted on 2025-04-21
1879 Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regeneration
Westerhoff, M.; Brocke-Ahmadinejad, N.; Schaumkessel, Y.; Köhrer, K.; Dönmez, A.; Ghodrat, R.; Borchardt, A.; Enjuanes-Ruiz, L.; Tigges, J.; Koch, K.; Fritz, G.; Kondadi, A. K.; Reichert, A. S.
10.1101/2025.04.18.649376 — cell biology — Posted on 2025-04-21
1880 Genomic and Phenotypic Characterization of Mupirocin Resistant Staphylococcus aureus Clinical Isolates
Virgillio, A. M.; Felton, E. A.; Jackson, J. K.; Kennedy, S. J.; Becker, D. N.; Lima, A.; Atrubin, K.; Cella, E.; Azarian, T.; Silbert, S.; Shaw, L. N.; Kim, K.
10.1101/2025.04.16.648996 — microbiology — Posted on 2025-04-21
1881 Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue.
Harm, T. A.; Arruda, B.; Siepker, C.; Fasina, O.; Groeltz, J.; Baker, A.; Phillips, R.; Jones, B.; Espina, V.; Seger, H.; Plummer, P.; Bell, T.; Nelli, R. K.
10.1101/2025.04.16.649193 — immunology — Posted on 2025-04-21
1887 Speech markers of psychedelic-induced psychological change
Kuc, J.; McAlpine, R. G.; Sellers, A.; Blackburne, G.; Lametti, D.; Skipper, J. I.
10.1101/2025.04.16.649217 — neuroscience — Posted on 2025-04-21
1888 Breaking the Link: Neural Dissociation of Attention and Working Memory through Inhibitory Control
Liu, Y.; Fu, Y.; Tang, E.; Wu, H.; Han, J.; Xie, M.; Zhang, Y.; Huang, J.; Liu, H.; Chen, H.; Qin, P.
10.1101/2025.04.17.649277 — neuroscience — Posted on 2025-04-21
1890 Feature-dependent decorrelation of sound representations across the auditory pathway
Gosselin, E.; Bagur, S.; Jamali, S.; Puel, J.-L.; Bourien, J.; Bathellier, B.
10.1101/2025.04.17.649364 — neuroscience — Posted on 2025-04-21
1891 Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance
Ozawa, T.; Nakagawa, I.; Uchida, Y.; Abe, M.; Macpherson, T.; Yamashita, Y.; Hikida, T.
10.1101/2025.04.16.649233 — neuroscience — Posted on 2025-04-21
1892 All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex
Frisby, S. L.; Halai, A. D.; Cox, C. R.; Clarke, A.; Shimotake, A.; Kikuchi, T.; Kuneida, T.; Arakawa, Y.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Rogers, T. T.; Lambon Ralph, M. A.
10.1101/2025.04.17.649404 — neuroscience — Posted on 2025-04-21
1896 Single-Cell Pharmacogenomic Landscapes of Epigenetic Therapy in Gastric Cancer
Xu, C.; Ma, H.; Sheng, T.; Lee, M. H.; Abdul Ghani, S. A. B.; Perlaza-Jimenez, L.; Huang, K. K.; Lim, S. K.; Srivastava, S.; Ong, X.; Tay, S. T.; Ho, S. W. T.; Tan, A. L. K.; Zhu, F.; Nasca, V.; Randon, G.; Ashktorab, H.; Cheng, A. S.-L.; Jeyasekharan, A. D.; Li, S.; Teh, M.; Sundar, R.; Powell, D. R.; Rosenbluh, J.; Pietrantonio, F.; Yong, W. P.; So, J. B.-Y.; Tan, P.
10.1101/2025.04.16.649236 — cancer biology — Posted on 2025-04-21
1899 OPTIMIZING AN EXOTENDON AT AN INCREASED RUNNING SPEED
Stingel, J.; Bianco, N. A.; Ong, C.; Hicks, J. L.; Delp, S.
10.1101/2025.04.15.648814 — bioengineering — Posted on 2025-04-21
1900 A novel inducible mtDNA mutator mouse model to study mitochondrial dysfunction with temporal and spatial control
Tobias-Wallingford, H.; Bartman, S.; Gaspar, L.; Gallagher, B.; Bassa, C.; Sotirakis, E.; Dubus, V.; Hemme, C.; Olson, L.; Coppotelli, G.; Ross, J. M.
10.1101/2025.04.17.649454 — genetics — Posted on 2025-04-21
1903 Biotic interactions shape the realised niche of toxic cyanobacteria
Ntetsika, P.; Eyring, S.; Merz, E.; Reyes, M.; Kaech, B.; Munch, S.; Dennis, S.; Baity Jesi, M.; Pomati, F.
10.1101/2025.04.16.649070 — ecology — Posted on 2025-04-20
1907 Widespread discordance between mRNA expression, protein abundance and de novo lipogenesis activity in hepatocytes during the fed-starvation transition
Landgraf, A.; Okada, J.; Horton, M.; Liu, L.; Solomon, S.; Qiu, Y.; Kurland, I. J.; Sidoli, S.; Pessin, J. E.; Shinoda, K.
10.1101/2025.04.15.649020 — bioinformatics — Posted on 2025-04-20
1909 Improving Thermal and Gastric Stability of Phytase via pH Shifting and Coacervation: A Demonstration of Bayesian Optimization for Rapid Process Tuning
Khongkomolsakul, W.; Buathong, P.; Yang, E.; Dadmohammadi, Y.; Zhou, Y.; Li, P.; Yang, L.; Frazier, P.; Abbaspourrad, A.
10.1101/2025.04.18.649602 — biochemistry — Posted on 2025-04-20
1910 Cellularly-Retained Fluorogenic Probes for Sensitive Cell-Resolved Bioactivity Imaging
Mauker, P.; Dessen-Weissenhorn, L.; Zecha, C.; Veprek, N.; Brandmeier, J.; Beckmann, D.; Kitowski, A.; Kernmayr, T.; Thorn-Seshold, J.; Kerschensteiner, M.; Thorn-Seshold, O.
10.1101/2025.04.17.649302 — biochemistry — Posted on 2025-04-20
1912 Sexual division of labour shapes hunter-gatherer spatial ranges
Padilla-Iglesias, C.; Nganga, D.; Amboulou, E.; Ruf, J.; Averti Ifo, S.; Vinicius, L.; Migliano, A. B.
10.1101/2025.04.15.649057 — evolutionary biology — Posted on 2025-04-20
1914 Progesterone Receptor Expressing Basal Cells and Progesterone Receptor-Primed Progenitors Redefine the Mammary Epithelial Hierarchy
Tharmapalan, P.; Waas, M.; McCloskey, C. W.; Defamie, V.; Aliar, K.; Simoes, B. M.; Clarke, R. B.; Howell, S. J.; Kislinger, T.; Berman, H. K.; Waterhouse, P.; Khokha, R.
10.1101/2025.04.16.648786 — cell biology — Posted on 2025-04-20
1915 Aerobic glycolysis and lactate regulate histone H3K18Lactylation occupancy to fine-tune gene expression in developing and mature retina
Gaur, M.; Liang, X.; Brooks, M. J.; Jiang, K.; Kumari, A.; English, M. A.; Cifani, P.; Antonelli, M. C.; Nellissery, J.; Fariss, R. N.; Campello, L.; Marchal, C.; Swaroop, A.
10.1101/2025.04.17.649437 — molecular biology — Posted on 2025-04-20
1917 Precon_all: A species-agnostic automated pipeline for non-human cortical surface reconstruction
Benn, R. A.; Xu, T.; Mars, R. B.; Boch, M.; Roumazeilles, L.; Heuer, K.; Toro, R.; Margulies, D. S.; Manzano-Patron, J. P.; Montesinos, P.; Galan-Arriola, C.; Lopez-Martin, G.; Sanchez-Gonzalez, J.; Duff, E. P.; Ibanez, B.
10.1101/2025.04.16.649072 — neuroscience — Posted on 2025-04-20
1918 In vivo MRI measurement of microstructural constraints for direct delivery of therapeutics within the brain
Castellano, A.; Pieri, V.; Segato, A.; Riva, M.; Pecco, N.; Yuan, T.; Vidotto, M.; Zani, D. D.; Brizzola, S.; Trovatelli, M.; Ravasio, G.; Secoli, R.; Galvan, S.; Dini, D.; Bello, L.; Rodriguez y Baena, F.; De Momi, E.; Falini, A.
10.1101/2025.04.15.648763 — neuroscience — Posted on 2025-04-20
1919 Nanobinders for Synaptotagmin 1 enable the analysis of synapticvesicle dynamics in rodent and human models.
Goel, R.; Jevdokimenko, K.; Rhem, R.; Hentze, J.; Agui-Gonzalez, P.; Ninov, M.; Lange, F.; Witkowska, A.; Bolz, S.; Pennacchietti, F.; Damenti, M.; Kaempf, N.; Khayenko, V.; Calatayud, C.; Malviya, V. N.; Chanaday, N. L.; Scaletti Hutchinson, E.; Liu, H.; Weyand, K.; Ivanova, D.; Wallis, T.; Small, C.; Maric, H. M.; Joensuu, M.; Cousin, M. A.; Meunier, F. A.; Verstreken, P. A.; Testa, I.; Kavalali, E. T.; Haucke, V.; Jakobs, S.; Urlaub, H.; Brose, N.; Cooper, B. H.; Stenmark, P.; Opazo, F.; Jahn, R.; Rizzoli, S. O.; Fornasiero, E. F.
10.1101/2025.04.16.649111 — neuroscience — Posted on 2025-04-20
1920 Neurologically altered brain activity may not look like aged brain activity: Implications for brain-age modeling and biomarker strategies
Gemein, L.; Gaubert, S.; Paquet, C.; Paillard, J.; Holst, S. C.; Tveitstol, T.; Haraldsen, I.; Hawellek, D.; Hipp, J.; Engemann, D.
10.1101/2025.04.15.648903 — neuroscience — Posted on 2025-04-20
1922 Topography Aware Optimal Transport for Alignment of Spatial Omics Data
Ceccarelli, F.; Lio, P.; Saez-Rodriguez, J.; Holden, S. B.; Tanevski, J.
10.1101/2025.04.15.648894 — bioinformatics — Posted on 2025-04-20
1925 Facilitating genome annotation using ANNEXA and long-read RNA sequencing
Hoffmann, N.; Besson, A.; Cadieu, E.; Lorthiois, M.; Le Bars, V.; Houel, A.; Hitte, C.; Andre, C.; Hedan, B.; Derrien, T.
10.1101/2025.04.16.648718 — bioinformatics — Posted on 2025-04-20
1926 Fast and accessible morphology-free functional fluorescence imaging analysis
Estrada Berlanga, A. A.; Kang, G.; Kwok, A.; Broggini, T.; Lawlor, J.; Kuchibhotla, K.; Kleninfeld, D.; Mishne, G.; Charles, A.
10.1101/2025.04.15.648462 — bioinformatics — Posted on 2025-04-20
1932 Tandem Mass Tag-Based High-Resolution LC-MS/MS identifies free D-aspartate-induced expression of proteins linked to schizophrenia and autism spectrum disorder
Errico, F.; Russo, R.; Carrillo, F.; Nuzzo, T.; di Vito, R.; Canonico, E.; Pedone, P. V.; Di Cunto, F.; Esposito, T.; Usiello, A.; Chambery, A.
10.1101/2025.04.18.649487 — biochemistry — Posted on 2025-04-20
1935 Cell type-specific epigenomic variation and its association with genotype in the human breast
Hauduc, A.; Steif, J.; Bilenky, M.; Moksa, M. M.; Cao, Q.; Ding, S.; Eaves, C. J.; Hirst, M.
10.1101/2025.04.16.648998 — genomics — Posted on 2025-04-20
1939 First record of a second invasive soft coral species, Latissimia ningalooensis, in southern Puerto Rico
Toledo-Rodriguez, D. A.; McFadden, C. S.; Jimenez Marrero, N. M.; Munoz-Maravilla, J. D.; Veglia, A. J.; Weil, E. F.; Schizas, N. V.
10.1101/2025.04.16.648000 — ecology — Posted on 2025-04-20
1940 Genome-wide mapping of mesoscale neuronal RNA organization and condensation
Becker, L. A.; Quinodoz, S. A.; Comi, T. J.; Kimchi, O.; Knowles, D. A.; Brangwynne, C. P.
10.1101/2025.04.19.649570 — molecular biology — Posted on 2025-04-20
1941 Aging alters mRNA processing in the mouse ovary
Vo, K.; Pei, G. J.; Thiyagarajan, R.; Fields, P. E.; Rumi, M. A. K.
10.1101/2025.04.16.649248 — molecular biology — Posted on 2025-04-20
1942 Multiomics approach identifies SERPINB1 as candidate progression biomarker for Spinocerebellar Ataxia type 2
Almaguer-Mederos, L. E.; Key, J.; Sen, N.-E.; Canet-Pons, J.; Doering, C.; Meierhofer, D.; Gispert-Sanchez, S.; Cuello-Almarales, D.; Almaguer-Gotay, D.; Osorio-Gonzalez, L. M.; Aguilera-Rodriguez, R.; Medrano-Montero, J.; Auburger, G.
10.1101/2025.04.18.649103 — molecular biology — Posted on 2025-04-20
1943 The 4th GPCR Dock: assessment of blind predictions for GPCR-ligand complexes in the era of AlphaFold
Chitsazi, R.; Wu, Y.; GPCR Dock 2021 participants, ; Stevens, R. C.; Zhao, S.; Kufareva, I.
10.1101/2025.04.18.647407 — molecular biology — Posted on 2025-04-20
1944 Integrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue
Schomakers, B. V.; Passadouro, A. S.; Tretowicz, M. M.; Simpson, P. J.; Jaspers, Y. R. J.; van Weeghel, M.; Hu, I. M.; Lamboo, C. M. E.; Cloutier, D.; Byrne, B. J.; van Klinken, J. B.; Janssens, P. M.; Piersma, S. R.; Jimenez, C. R.; Vaz, F. M.; Salomons, G. S.; van der Velden, J.; Houtkooper, R. H.; Mosegaard, S.
10.1101/2025.04.17.649294 — molecular biology — Posted on 2025-04-20
1945 VEGF-B/NRP1 Signaling Modulates Mitochondrial Homeostasis and Cardiac Function After Myocardial Infarction
Mukhopadhyay, D.; Varanasi, S. M.; Sabharwal, A.; Kar, R.; Magnano, C.; Dorairaj, A.; Wang, E.; Dutta, S. K.; Das, P.; Ekker, S. C.; Wang, Y.; Singh Angom, R.
10.1101/2025.04.18.649613 — molecular biology — Posted on 2025-04-20
1948 Antigen-scaffolds loaded with hyper-stable Neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy
Ormhoej, M.; Munk, K. K.; Tvingsholm, S.; Ramanathan, K.; Bentzen, A. K.; Kladis, G.; Aasbjerg, G. N.; Nos, G.; Tamhane, T.; Halldorsdottir, H. R.; Nybo, S.; Frej, M. S.; Johansen, K. H.; Kadivar, M.; Hadrup, S. R.
10.1101/2025.04.16.649086 — immunology — Posted on 2025-04-20
1949 Metabolic Reprogramming of Pathogenic CD4+ T Helper Cells Attenuates Inflammatory Bowel Disease Pathogenesis
Mishra, S. K.; Abdelrahman, L. M.; Davidson, H. M.; Kim Lee, H. S.; Valenzuela-Perez, L.; Hassan, O. M.; Faubion, W. A.; Hirsova, P.; Bamidele, A. O.
10.1101/2025.04.15.649047 — immunology — Posted on 2025-04-20
1950 Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy
Lemaitre, F.; Mercey, O.; Mean, I.; Paulin, E.; Dutoit, V.; Rath, J.; Migliorini, D.; Arber, C.; Guichard, P.; HAMEL, v.; Wolf, B.
10.1101/2025.04.15.648816 — immunology — Posted on 2025-04-20
1955 Improved Injury Detection Through Harmonizing Multi-Site Neuroimaging Data after Experimental TBI: A Translational Outcomes Project in NeuroTrauma (TOP-NT) Consortium Study
Kislik, G.; Fox, R.; Korotcov, A. V.; Zhou, J.; Febo, M.; Moghadas, B.; Bibic, A.; Zou, Y.; Wan, J.; Koehler, R. C.; Adebayo, T.; Burns, M. P.; McCabe, J. T.; Wang, K. K.; Huie, J. R.; Ferguson, A. R.; Harris, N. G.; The TOP-NT Investigators,
10.1101/2025.04.15.649026 — neuroscience — Posted on 2025-04-20
1956 Cocaine-induced immediate-early gene expression in the nucleus accumbens: roles of separate cAMP sensors
Zhang, H.-Y.; Salman, T.; Bi, G.-H.; Jiang, S. Z.; Gerfen, C. R.; Lutas, A.; Xu, W.; Xi, Z.-X. `; Eiden, L. E.
10.1101/2025.04.15.648980 — neuroscience — Posted on 2025-04-20
1958 Host-specific platelet-activating factor acetylhydrolase selectively remodels diacylglycerophospholipids to control schistosome development
Ertl, J.; Prodjinotho, U. F.; Rao, Z.; Anisuzzaman, A.; Schluckebier, J.; Hamway, Y.; Baar, P.; Haslbeck, M.; Grevelding, C. G.; Haeberlein, S.; Falcone, F. H.; Schulz, S.; Koeberle, A.; Prazeres da Costa, C.
10.1101/2025.04.16.649075 — systems biology — Posted on 2025-04-20
1959 Photosynthesis regulation impacts carbon and nitrogen assimilation in the diazotrophic cyanobacterium Anabaena sp. PCC 7120
Santin, A.; Storti, M.; Mezzavilla, M.; Fortunato, A.; Arcudi, F.; Flores, E.; Morosinotto, T.; Perin, G.
10.1101/2025.04.16.649060 — plant biology — Posted on 2025-04-20
1960 Developmentally-controlled generation of tRNA halves facilitates translational repression during sexual reproduction
Juarez-Gonzalez, V. T.; Marquez-Molins, J.; Cheng, J.; Reig-Valiente, J. L.; Kutashev, K.; Rosa, S.; Martinez, G.
10.1101/2025.04.15.648877 — plant biology — Posted on 2025-04-20
1961 A tRNA-gRNA multiplexing system for CRISPR genome editing in Marchantia polymorpha.
Frangedakis, E.; Yelina, N.; Eeda, S. K.; Romani, F.; Fragkidis, A.; Haseloff, J.; Hibberd, J.
10.1101/2025.04.18.649274 — plant biology — Posted on 2025-04-20
1962 Brain-derived exosome biomarkers of neuroinflammation and neuronal functional iron deficiency in newborns of overweight-obese mothers
Tran, P. V.; Harris, A. C.; Maxim, Z. L.; Munirathinam, M.; Muelken, P.; Javadova, N.; Kruttiventi, S.; Kling, P. J.; Baack, M. L.; Georgieff, M. K.
10.1101/2025.04.15.648967 — physiology — Posted on 2025-04-20
1965 A Single-Cell Atlas Of Human Pediatric Liver Reveals Age-Related Hepatic Gene Signatures
Edgar, R. D.; Nakib, D.; Camat, D.; Chung, S.; Lumanto, P.; Atif, J.; Perciani, C. T.; Ma, X. Z.; Thoeni, C.; Selvakumaran, N.; Manuel, J.; Sayed, B.; Huysentruyt, K.; Ricciuto, A.; McGilvray, I.; Avitzur, Y.; Bader, G. D.; MacParland, S. A.
10.1101/2025.04.16.649149 — genomics — Posted on 2025-04-20
1968 The crosstalk between the anterior hypothalamus and the locus coeruleus during wakefulness is associated with low frequency oscillations power during sleep
Mortazavi, N.; Talwar, P.; Koshmanova, E.; Sharifpour, R.; Beckers, E.; Paparella, I.; Balda, F.; Bastin, C.; Collette, F.; Lamalle, L.; Phillips, C.; Zubkov, M.; Vandewalle, G.
10.1101/2025.04.15.647930 — neuroscience — Posted on 2025-04-20
1971 Development of a 24-Channel 3T Phased-Array Coil for fMRI in Awake Monkeys - Mitigating Spatiotemporal Artifacts in Ferumoxytol-Weighted Functional Connectivity Estimation
Autio, J. A.; Yoshida, A.; Kawabata, Y.; Ohno, M.; Nishigori, K.; Ose, T.; Smith, S. M.; Van Essen, D. C.; Glasser, M. F.; Hayashi, T.
10.1101/2025.04.15.648822 — neuroscience — Posted on 2025-04-20
1973 Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model
Choudhury, A.; Yesiltepe, M.; Lashley, T.; Singh, V.; Yin, T.; Fernandez, A.; D'Adamio, L.; Ahn, H. J.
10.1101/2025.04.15.649002 — neuroscience — Posted on 2025-04-20
1976 Electrochemical Metabolic Profiling Reveals Mitochondrial Hyperactivation and Enhanced Neural Progenitor Proliferation in MLC1-Mutant Human Cortical Organoids
Koo, K.-M.; Choi, J.-S.; Nam, Y.-K.; Kim, H.-J.; Kim, C.-D.; Jeong, S.-H.; Jang, H.-J.; Lim, K.; Lim, B.-C.; Kim, T.-H.; Cho, K.-O.
10.1101/2025.04.16.647364 — neuroscience — Posted on 2025-04-20
1978 Circadian-Related Dynamics of the Endocannabinoid System in Male Mouse Brain
Farfara, D.; Lewitus, G. M.; Korin, B.; Hajjo, H.; Feder, C. L.; Sulimani, L.; Berman, P.; Procaccia, S.; Azulay-Debby, H.; Meiri, D.
10.1101/2025.04.15.648929 — neuroscience — Posted on 2025-04-20
1979 Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson's Disease
Knab, F.; Lee, J.-H.; Nirujogi, R.; Menden, K.; Busra Isik, F.; Rajkumar, A. P.; Czemmel, S.; Fitzgerald, J.; Gasser, T.
10.1101/2025.04.15.648997 — neuroscience — Posted on 2025-04-20
1980 Distinct impacts of sodium channel blockers on the strength-duration properties of human motor cortex neurones
Rocchi, L.; Brown, K.; Di Santo, A.; Smith, H.; Peterchev, A. V.; Rothwell, J. C.; Hannah, R.
10.1101/2025.04.16.648964 — neuroscience — Posted on 2025-04-20
1981 Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty
Ogasawara, T.; Xu, K.; Snyder, A. Z.; Perlmutter, J. S.; Tu, Z.; Minamimoto, T.; Inoue, K.-i.; Takada, M.; Monosov, I. E.
10.1101/2025.04.15.648986 — neuroscience — Posted on 2025-04-20
1985 Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab
Kyyriainen, J.; Della Pietra, A.; Torkamani-Azar, M.; Gomez- Budia, M.; Novosolova, N.; Eronen, H.; Narvaez, O.; Paasonen, E.; Lezhneva, V.; Pelkonen, A.; Saveleva, L.; Huotarinen, A.; Jutila, L.; Rauramaa, T.; Immonen, A.; Leinonen, V.; Tohka, J.; Grohn, O.; Kalviainen, R.; Malm, T.; Sierra, A.
10.1101/2025.04.15.648977 — neuroscience — Posted on 2025-04-20
1986 Toward Unified Biomarkers for Focal Epilepsy
Wang, S. H.; Ferrari, P.; Arnulfo, G.; Marzulli, M.; Degras, D.; Myrov, V.; Palva, S.; Nobili, L.; Ciuciu, P.; Palva, M.
10.1101/2025.04.15.647522 — neuroscience — Posted on 2025-04-20
1987 Large-scale single-neuron recording using the uFINE array in human cortex
Wu, S.; Yan, Z.; Kong, C.; Li, X.; Dong, Q.; Qian, Y.; Chen, G.; Chen, B.; Ren, C.; Lu, J.; Zhao, Z.; Jiang, X.; Li, X.
10.1101/2025.04.14.648657 — bioengineering — Posted on 2025-04-20
1988 Development of Replay-DMN Coordination Predicts Entorhinal Grid Codes
Pang, L.; Qu, Y.; Ou, J.; Wu, S.; Luo, Y.; Gohil, C.; Woolrich, M.; Behrens, T.; Liu, Y.
10.1101/2025.04.02.646732 — neuroscience — Posted on 2025-04-20
1989 In vivo mRNA delivery to the lung vascular endothelium by dicationic Charge-Altering Releasable Transporters
AbdElwakil, M.; Ni, J.; Ramsay-Burrough, S.; Hurst, P. J.; McClellan, R.; Khasnavis, S. R.; Jia, Y.; Masud, S. R.; Blake, T. R.; Sallets, A.; Haabeth, O.; Sagiv-Barfi, I.; Czerwinski, D. K.; Levy, R.; Wender, P. A.; Kumar, M. E.; Waymouth, R. M.
10.1101/2025.04.19.649649 — bioengineering — Posted on 2025-04-19
1991 Theobromine is Associated with Slower Epigenetic Ageing
Saad, R.; Costeira, R.; Matias Garcia, P.; Gieger, C.; Suhre, K.; Peters, A.; Kastenmuller, G.; Rodriguez Mateos, A.; Dias, C.; Menni, C.; Waldenberger, M.; Bell, J. T.
10.1101/2025.04.15.648884 — genetics — Posted on 2025-04-19
1994 Contralateral Prefrontal and Network Engagement during Left DLPFC 10 Hz rTMS: An Interleaved TMS-fMRI Study in Healthy Adults
van Hattem, T.; Chang, K.-Y.; Tik, M.; Taylor, P.; Bjorklund, J.; Bulubas, L.; Padberg, F.; Keeser, D.; Campana, M.
10.1101/2025.04.14.648588 — neuroscience — Posted on 2025-04-19
1995 Ploidy variation modulates outbreeding response and promotes mating system evolution in a selfing plant lineage.
Olmedo-Castellanos, C.; Garcia-Munoz, A.; Ferron, C.; Bakkali, M.; Munoz-Pajares, A. J.; Abdelaziz, M.
10.1101/2025.04.15.648901 — plant biology — Posted on 2025-04-19
1996 Single and Multiple Buds Form characteristics in Amorphophallus muelleri
Liu, Y.; Li, Z.; He, J.; Li, W.; Xie, Y.; Ge, S.; Wang, R.; Wu, X.
10.1101/2025.04.14.648843 — physiology — Posted on 2025-04-19
2001 Large-scale single-neuron recording using the uFINE array in human cortex
Wu, S.; Yan, Z.; Kong, C.; Li, X.; Dong, Q.; Qian, Y.; Chen, G.; Chen, B.; Ren, C.; Lu, J.; Zhao, Z.; Jiang, X.; Li, X.
10.1101/2025.04.14.648657 — bioengineering — Posted on 2025-04-19
2004 Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control
Tanwar, V. S.; Malek, V.; Wang, J.; Luo, Y.; Malhi, N. K.; Zhang, H.; Abdollahi, M.; Lanting, L.; Senapati, P.; Das, S.; Reddy, M. A.; Zang, C.; Miller, C. L.; Chen, Z. B.; Natarajan, R.
10.1101/2025.04.14.648851 — biochemistry — Posted on 2025-04-19
2005 BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.
Heininger, H.; Feng, X.; Altunkaya, A.; Zheng, F.; Stockinger, F.; Wefers, B.; Müller, S. A.; Giesbertz, P.; Tschirner, S. K.; Shqau, D.; Adelsberger, H.; Ponomarenko, A.; Fenzl, T.; Alzheimer, C.; Lichtenthaler, S. F.; Huth, T.
10.1101/2025.04.17.648898 — animal behavior and cognition — Posted on 2025-04-19
2007 RNase H1 counteracts DNA damage and ameliorates SMN-dependent phenotypes in a Drosophila model of Spinal Muscular Atrophy
Scatolini, L.; Graziadio, L.; Guerrini, D.; Maccallini, P.; Marino, C.; di Vito, R.; Hassan, A.; Grimaldi, M.; Fidaleo, M.; Dehghannasiri, R.; Proietti, G.; Piergentili, R.; Salvati, E.; Cacchione, S.; De Pitta, C.; Doksani, Y.; D'Ursi, A. M.; Wakefield, J.; Chen, L.; Gatti, M.; Colantoni, A.; Usiello, A.; Raffa, G. D.
10.1101/2025.04.17.649348 — genetics — Posted on 2025-04-19
2008 L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression
Gu, W.; Wang, X.; Solmonson, A.; Cai, L.; Tasdogan, A.; Franklin, J.; Zhang, Y.; Zhang, H.; Westfall, A. K.; Rowe, A.; Trivedi, H.; Faubert, B.; Wu, Z.; Sudderth, J.; Zacharias, L. G.; Afroze, B.; Bezprozvanny, I.; Sudarshan, S.; Cai, F.; McBrayer, S. K.; Mathews, T. P.; DeBerardinis, R. J.
10.1101/2025.04.16.649033 — genetics — Posted on 2025-04-19
2010 Early warning signals do not predict a warming-induced experimental epidemic
Jarvis-Cross, M.; Kirk, D.; Krichel, L.; Luijckx, P.; Molnar, P.; Krkosek, M.
10.1101/2025.04.14.648789 — ecology — Posted on 2025-04-19
2012 A more-than-human political ecology of Indonesian songbird trade
Fiennes, S. B.; Hardianto, N.; Anaswari, S. D.; Damayani, L.; Haryono, J.; Jackson, T.; Dwiyahreni, A. A.; Birchall, C.; Holmes, G.; Hassall, C.
10.1101/2025.04.15.648493 — ecology — Posted on 2025-04-19
2014 Intraspecific bacterial competition mediated by rapidly diversifying tailocin and prophage loci
Kauffman, S. J.; Awori, R. M.; Allwell, E. C.; Taylor, A.; Bashey, F.; Goodrich-Blair, H.
10.1101/2025.04.19.648921 — microbiology — Posted on 2025-04-19
2016 Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques
Teunis, C. J.; Zijlstra, L. F.; Levels, J. H. M.; Vinten, K. T.; Tretowicz, M. M.; Mol, B. M. M.; Sluimer, J. C.; Mokry, M.; Murphy, A. J.; Kroon, J.; Stroes, E. S.; De Kleijn, D.; Houtkooper, R. H.; Neele, A. E.; Hanssen, N. M.
10.1101/2025.04.14.648852 — immunology — Posted on 2025-04-19
2017 Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype
Boccia, T.; Fattori, V.; Deroco Veloso da Silva, M.; Asquith, N. L.; Pan, W.; Rogers, M. S.; Zanoni, I.; Cuenca, A.
10.1101/2025.04.15.648954 — immunology — Posted on 2025-04-19
2021 Spatially convergent fMRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain aging
Chesebro, A. G.; Rohm, L. R.; Antal, B. B.; Weistuch, C.; Strey, H. H.; Ratai, E.-M.; Jones, D. T.; Mujica-Parodi, L. R.
10.1101/2025.04.14.648801 — neuroscience — Posted on 2025-04-19
2022 The cerebellar components of the human language network
Casto, C.; Small, H.; Poliak, M.; Tuckute, G.; Lipkin, B.; Wolna, A.; D'Mello, A. M.; Fedorenko, E.
10.1101/2025.04.14.645351 — neuroscience — Posted on 2025-04-19
2023 Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution
Pacholko, A. G.; Schaeffer, S. M.; Santisteban, M. M.; Wang, G.; Racchumi, G.; Faraco, G.; Anrather, J.; Iadecola, C.
10.1101/2025.04.14.648770 — neuroscience — Posted on 2025-04-19
2025 Human nasal olfactory stem cell-derived extracellular vesicles improve the repair of rat nerves
Bonnet, M.; Seblani, M.; Witters, M.; Marqueste, T.; Jaloux, C.; Morando, P.; Decherchi, P.; Feron, F.; Guiraudie-Capraz, G.
10.1101/2025.04.14.648811 — neuroscience — Posted on 2025-04-19
2027 Embodied Singing: Dual Role of Interoception in Vocal Expertise and Musical Competence
Zamorano, A. M.; Haumann, N. T.; Ligato, D.; Maublanc, P.; Brattico, E.; Vuust, P.; Kleber, B.
10.1101/2025.04.14.648736 — neuroscience — Posted on 2025-04-19
2029 Mechanical environment afforded by engineered polymer hydrogel critically regulates survival of neural stem cells transplanted in the injured spinal cord via Piezo1-mediated mechanotransduction
Park, H. H.; Kim, Y.; Jang, B. S.; Geniscan, S.; Hwang, D. H.; Seo, Y.; Jee, S.-A.; Seo, H. G.; Kim, H. S.; Einisadr, A.; Kim, H.-J.; Lee, S.; Kwon, S.; Kim, K. S.; Lee, K. I.; Lee, J. Y.; Park, J. M.; Kim, Y.-M.; Song, S.-C.; Kim, B. G.
10.1101/2025.04.15.648586 — neuroscience — Posted on 2025-04-19
2032 Prex1 controls glucose homeostasis by limiting glucose uptake and mitochondrial metabolism in liver through GEF-independent regulation of Gpr21
Chu, J. Y.; Tsonou, E.; Machin, P. A.; MacLellan-Gibson, K.; Roberts, A.; Chetwynd, S. A.; McCormack, A. T.; Stephens, J. C.; Benetti, E.; Kinsella, G. K.; Baker, D.; Hornigold, D. C.; Welch, H. C. E.
10.1101/2025.04.14.648781 — physiology — Posted on 2025-04-19
2036 Plasmodium Repetome: A mysterious space with a wealth of information
Hora, R.; Mishra, P. C.; Kaur, S.; Singh, K.; Kumar, V.; Behl, A.; Manhas, A.
10.1101/2025.04.14.647515 — bioinformatics — Posted on 2025-04-19
2041 Covalent targeting leads to the development of LIMK1 isoform-selective inhibitors
Mandel, S.; Hanke, T.; Prendiville, N.; Baena-Nuevo, M.; Berger, L. M.; Farges, F.; Schwalm, M. P.; Berger, B. T.; Kraemer, A.; Elson, L.; Saraswati, H.; Azeez, K. R. A.; Dederer, V.; Mathea, S.; Corrionero, A.; Alfonso, P.; Keller, S.; Gstaiger, M.; Krause, D. S.; Mueller, S.; Roehm, S.; Knapp, S.
10.1101/2025.04.17.649341 — biochemistry — Posted on 2025-04-19
2044 Prevalent cross-cell type QTL trans-regulatory genetic effects impacting innate lymphoid cells in the small intestine
Xu, M.; Gosik, K.; Zhang, Y.; Ashenberg, O.; Li, C.; Li, H.; Liu, K.; Churchill, G. A.; Gatti, D. M.; Choi, K.; Philip, V.; Graham, D.; Dey, K. K.; Xu, H.; Xavier, R. J.; Regev, A.
10.1101/2025.04.16.649031 — genetics — Posted on 2025-04-19
2045 Prediction in trait-based ecology: global simulations of specific leaf area using a trait-based dynamic vegetation model
Langan, L.; Kattenborn, T.; Roemermann, C.; Scheiter, S.; Anders, T.; Wolf, S.; Dantas de Paula, M.; Hickler, T.
10.1101/2025.04.14.648688 — ecology — Posted on 2025-04-19
2047 The effect of Shifts in Fish Community Structure on PCDD/F temporal variability in common guillemot (Baltic Sea)
Ammar, Y.; olsson, j.; Gorokhova, E.; Skold, M.; Faxneld, S.; Hentati-Sundberg, J.; Soerensen, A. L.
10.1101/2025.04.14.648406 — ecology — Posted on 2025-04-19
2048 Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development
Jevans, B.; Chanpong, A.; Peruzza, L.; Perin, S.; Cairns, B.; Tagdiwala, P.; Vanden Berghe, P.; Hennig, G. W.; McCann, C. J.
10.1101/2025.04.17.649306 — developmental biology — Posted on 2025-04-19
2049 Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations.
Philips, E. A.; Alharithi, Y.; Wilson, T. D.; Broberg, C.; Davis, B. A.; Koch, S.; Carbone, L.; Rubinstein, J.; Gurley, S. B.; Rugonyi, S.; Kumar, S.; Maloyan, A.
10.1101/2025.04.15.648971 — molecular biology — Posted on 2025-04-19
2050 In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds
Wagner, A.; Lautaoja-Kivipelto, J.; Pehkonen, K.; Hassinen, A.; Kuusela, M.; Röttger, L.; Herbers, E.; Ioannidou, A.; Mädler, S.; Rothenaigner, I.; Srinivasan, S.; Laasonen, S.; Rahman, M. T.; Elomaa, P.; Kortetjärvi, S.; Olsson, A.; Ukkola, O.; Hadian, K.; Mann, M.; Peltoniemi, H.; Pietiläinen, K. H.; Klingenspor, M.; Virtanen, K. A.; Hagberg, C. E.; Pirinen, E.
10.1101/2025.04.16.649074 — molecular biology — Posted on 2025-04-19
2052 A Highly Potent Human Antibody Neutralizing All Serotypes of BK Polyomavirus
Esslinger, C.; Hillenbrand, M.; Weber, M.; Schmitt, S.; Eicher, B.; Seidenberg, J.; Rutkauskaite, J.; Stöckli, B.; Townsend, C.; Huynh-Do, U.; Schachtner, T.; Delbue, S.; Maeder, A.
10.1101/2025.04.14.648680 — immunology — Posted on 2025-04-19
2053 Mapping the spatiotemporal dynamics of de novo protein synthesis during long-term memory formation
Evans, H. T.; Adler, D.; Selles, M. C.; Kalavai, S. V.; Yu, A.; Wu, V.; Denil, E.; Golhan, E. N.; Polavarapu, A.; Balamoti, E.; Chao, M. V.; Froemke, R. C.; Klann, E.
10.1101/2025.04.17.649250 — neuroscience — Posted on 2025-04-19
2054 Three cortical streams for somatosensory information processing
Niu, M.; Froudist-Walsh, S.; Hou, Y.; Rapan, L.; Vincon, N.; Kennedy, H.; Xu, T.; Palomero-Gallagher, N.
10.1101/2025.04.14.647517 — neuroscience — Posted on 2025-04-19
2055 Newly trained navigation and verbal memory skills elicit changes in task-related networks but not brain structure
Zheng, L.; Boogaart, Z.; McAvan, A.; Garren, J.; Doner, S.; Wilkes, B. J.; Groves, W.; Yuksel, E.; Cherep, L.; Ekstrom, A.; Weisberg, S. M.
10.1101/2025.04.14.648747 — neuroscience — Posted on 2025-04-19
2057 Cardio-respiratory interactions in interoceptive perception: The role of heartbeat-modulated cortical oscillations
Zaccaro, A.; della Penna, F.; Bubbico, F.; Bayram, B.; Parrotta, E.; Perrucci, M. G.; Costantini, M.; Ferri, F.
10.1101/2025.04.14.648690 — neuroscience — Posted on 2025-04-19
2060 White matter geometry confounds Diffusion Tensor Imaging Along Perivascular Space (DTI-ALPS) measures
Schilling, K.; Newton, A. T.; Tax, C. M.; Nilsson, M.; Chamberland, M.; Anderson, A. W.; Landman, B. A.; Descoteaux, M.
10.1101/2025.04.14.648733 — neuroscience — Posted on 2025-04-19
2062 Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease
Anijarv, T. E.; Ossenkoppele, R.; Smith, R.; Pichet Binette, A.; Collij, L. E.; Behjat, H. H.; Rittmo, J.; Karlsson, L.; Ahmadi, K.; Strandberg, O.; the Alzheimer's Disease Neuroimaging Initiative, ; van Westen, D.; Vogel, J. W.; Stomrud, E.; Palmqvist, S.; Mattsson-Carlgren, N.; Spotorno, N.; Hansson, O.
10.1101/2025.04.15.648728 — neuroscience — Posted on 2025-04-19
2065 Anaesthesia disrupts mesoscale signal propagation in spite of enhanced responsivity in frontal but not in parietal cortex
Dwarakanath, A.; Khalili-Ardali, M.; Gay, M.; HV, R.; Roustan, M.; Dehaene, S.; Jarraya, B.; Panagiotaropoulos, T.
10.1101/2025.04.15.648923 — neuroscience — Posted on 2025-04-19
2067 Targeted degradation of α-synuclein prevents PFF-induced aggregation
Carton, B.; Gelders, G.; Sathe, G.; Kocaturk, N.; Roth, S.; Macartney, T.; Van elsen, J.; De Muynck, L.; Buist, A.; Moechars, D.; Sapkota, G. P.
10.1101/2025.04.15.648905 — neuroscience — Posted on 2025-04-19
2068 An integrated landscape of mRNA and protein isoforms
Kedan, A.; Zauber, H.; Wang, M.-R.; Zhu, Q.; Fang, L.; Chen, W.; Selbach, M.
10.1101/2025.04.16.648713 — systems biology — Posted on 2025-04-19
2069 Age deceleration and reversal gene patterns in dauer diapause
Totska, K.; Barata, J. C. V. V.; Sandt, W.; Meyer, D. H.; Schumacher, B.
10.1101/2025.04.14.648662 — systems biology — Posted on 2025-04-19
2070 Transcriptional competition biases the effects of second messengers in E. coli
Ripamonti, A.; Lacassin, M.; Droghetti, R.; Bokinsky, G.; Cosentino Lagomarsino, M.
10.1101/2025.04.15.648722 — systems biology — Posted on 2025-04-19
2071 A new method to quantify the spatiotemporal localization of SnRK1.1
Brugnara, C. B.; Diaz, M. C.; Bultri, J.; Liebsch, D.; Hita, F.; Aguilar, D.; Fusari, C. M.; Dengjel, J.; Levi, V.; Blanco, N. E.
10.1101/2025.04.14.648863 — plant biology — Posted on 2025-04-19
2072 Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells
De Coster, E.; De Clerck, K.; De Clercq, C.; Li, W.; Punj, D.; Vanmeerhaeghe, B.; De Smedt, S.; Braeckmans, K.; Hadady, H.; Remaut, K.; Johnson, T. V.; Peynshaert, K.
10.1101/2025.04.14.648093 — pharmacology and toxicology — Posted on 2025-04-19
2073 Interleukin-6 is critical in the development of gcn2-mutation associated pulmonary vascular disease in mice
Schwiening, M.; Gao, Q.; Southwood, M.; Crosby, A.; Moore, S.; Valer, J. A.; Veale, N.; Dunmore, B.; Upton, P. D.; Thompson, R.; Morrell, N.; Marciniak, S. J.; Soon, E.
10.1101/2025.04.14.648729 — pathology — Posted on 2025-04-19
2074 THLANet: A Deep Learning Framework for Predicting TCR-pHLA Binding in Immunotherapy Applications
Long, X.; Yang, Q.; Dong, W.; Li, X.; Wang, K.; Dong, S.; Luo, G.; Zhang, X.; Yang, T.; Gao, X.; Wang, G.
10.1101/2025.04.14.648678 — bioinformatics — Posted on 2025-04-19
2076 Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia
Doherty-Boyd, W. S.; Tsimbouri, M. P.; Jayawarna, V.; Walker, M.; Taqi, A. F.; Mahon, N.; Meek, D.; Young, P.; Miller, A.; West, A. G.; Salmeron-Sanchez, M. G.; Dalby, M.; Donnelly, H.
10.1101/2025.04.16.649170 — bioengineering — Posted on 2025-04-19
2077 Focused Ultrasound Crosslinkable Granular Hydrogels
Claxton, N. L.; He, E.; Bukovic, K.; Thim, E. A.; Letteri, R. A.; Caliari, S. R.; Price, R. J.; DeWitt, M. R.; Highley, C. B.
10.1101/2025.04.14.648397 — bioengineering — Posted on 2025-04-19
2079 Huib32: A Potent and Selective USP32 Inhibitor Modulating Endosomal Processes and Advancing Cell-Permeable USP32 Probes
Scherpe, S.; Pol, V.; Kooij, R.; Pinto-Fernandez, A.; Tjokrodirijo, R. T. N.; O'Brien, D. P.; Vendrell, I.; Hameed, D. S.; van Veelen, P. A.; Kessler, B. M.; Geurink, P. P.; Sapmaz, A.
10.1101/2025.04.19.649632 — biochemistry — Posted on 2025-04-19
2081 An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish
Iannucci, L. E.; Velanganni, S. M. T.; Murphy, M. R.; Donahue, C. E. T.; Anderson, W. K.; Rogers, C. E.; Saul, A. J.; Rogers, K. W.
10.1101/2025.04.17.649426 — developmental biology — Posted on 2025-04-19
2089 Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress
Hall, A. G.; Burek, D. J.; Hisey, E. E.; Seabrook, L. T.; Fritsch, E. L.; Beatty, Z. G.; Ressler, K. J.; Kangas, B. D.; Carlezon, W. A.
10.1101/2025.04.18.649529 — animal behavior and cognition — Posted on 2025-04-19
2090 Social Context Restructures Behavioral Syntax in Mice
Ritter, M.; Shipley, H.; Deiana, S.; Hengerer, B.; Wotjak, C. T.; Brecht, M.; Bogadhi, A. R.
10.1101/2025.04.17.648924 — animal behavior and cognition — Posted on 2025-04-19
2096 Neural dynamics in superior colliculus of freely moving mice
Sharp, S. L.; Shin, J.; Martins, D. M.; Jones, K.; Niell, C. M.
10.1101/2025.04.16.648828 — neuroscience — Posted on 2025-04-19
2100 Diversification of large-effect loci in a duplicated genomic region leads to complex phenotypes
Barry, P. D.; Howe, N.; Owens, G. L.; Baetscher, D.; D'Amelio, K.; Vulstek, S.; Russell, J.; Lee, E.; Barclay, A.; Gharrett, A. J.; Tallmon, D. A.; Larson, W.
10.1101/2024.03.30.587279 — genomics — Posted on 2025-04-19
2101 The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk
Liang, Q.; Jiang, Y.; Shieh, A. W.; Zhou, D.; Chen, R.; Wang, F.; Xu, M.; Niu, M.; Wang, X.; Pinto, D.; Wang, Y.; Cheng, L.; Vadukapuram, R.; Zhang, C.; Grennan, K.; Giase, G.; The PsychENCODE Consortium, ; White, K. P.; Peng, J.; Li, B.; Liu, C.; Chen, C.; Wang, S. H.
10.1101/2023.06.04.543603 — genetics — Posted on 2025-04-19
2103 Closest relatives of poxviruses are spread in the gut of humans and animals worldwide: the egoviruses
Gaia, M.; Ruscheweyh, H.-J.; Eren, A. M.; Koonin, E. V.; Sunagawa, S.; Krupovic, M.; Delmont, T. O.
10.1101/2024.03.23.586382 — microbiology — Posted on 2025-04-19
2104 WMH-DualTasker: A weakly-supervised deep learning model for automated white matter hyperintensities segmentation and visual rating prediction
Wu, Y.; Dong, Z.; Li, H. B.; Chong, Y. F.; Ji, F.; Chong, J. S. X.; Tang, N. R. J.; Hilal, S.; Fu, H.; Chen, C. L.-H.; Zhou, J. H.
10.1101/2024.11.12.623137 — neuroscience — Posted on 2025-04-19
2107 A neural mechanism for compositional generalization of structure in humans
Luettgau, L.; Chen, N.; Erdmann, T.; Veselic, S.; Kurth-Nelson, Z.; Moran, R.; Dolan, R. J.
10.1101/2024.09.20.614119 — neuroscience — Posted on 2025-04-19
2110 Reinforcement of Fibrillar Collagen Hydrogels with Bioorthogonal Covalent Crosslinks
Brunel, L. G.; Long, C. M.; Christakopoulos, F.; Cai, B.; de Paiva Narciso, N.; Johansson, P. K.; Singhal, D.; Enejder, A.; Myung, D.; Heilshorn, S. C.
10.1101/2025.04.13.648560 — bioengineering — Posted on 2025-04-19
2113 Fluid forces control structural remodeling of blind-ended lymphatic microvessels
Holter, J. C.; Agarwal, S. S.; Tinapple, J. W.; Barlage, J. M.; Jones, T. H.; Song, J. W.
10.1101/2025.04.14.648799 — bioengineering — Posted on 2025-04-19
2115 Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone
Kawamura, K.; Diederich, A. R.; Gerisch, B.; Ripa, R.; Latza, C.; Steiner, J. D.; Fernandes, S.; Artoni, F.; Meyer, D. H.; Sant, D.; Oehm, S.; Grundmann, F.; Müller, R.-U.; Demetriades, C.; Antebi, A.
10.1101/2025.04.14.648802 — genetics — Posted on 2025-04-19
2116 Assessing plant phenological changes based on drivers of spring phenology
Jiang, Y.; Mayor, S.; Chu, X.; Ye, X.; Man, R.; Tao, J.; Dang, Q.-L.
10.1101/2025.04.13.648654 — ecology — Posted on 2025-04-19
2118 Personalized Brain Morphometric Feature as a Transdiagnostic Predictor of Psychopathology: Insights from Dual Systems Models
Kang, M.; Song, K.-r.; Zhang, J.-l.; Xu, L.; Zhang, Y.; Zhao, Z.; Deng, H.; Fang, X.; Potenza, M. N.; Zhang, J.
10.1101/2025.04.14.644899 — developmental biology — Posted on 2025-04-19
2119 Expanding Targeted Instrumentation for Discovery Applications: Complement Reporter Ion Quantification with a Quadrupole-Ion Trap Instrument
Cruz, E. R.; Johnson, A. N.; Pujari, V.; Nguyen, T.; Stadlmeier, M.; Wang, J.; Jacob, C.; McAlister, G. C.; Remes, P. M.; Wühr, M.
10.1101/2025.04.18.649483 — systems biology — Posted on 2025-04-19
2121 β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosis
Sato, R.; Imamura, K.; Tsukui, T.; Yoshida, T.; Tomita, Y.; Fujino, K.; Ikeda, T.; Onizawa, K.; Sogo, T.; Combs, C. A.; Murgai, M.; Kopp, J. B.; Suzuki, M.; Sakagami, T.; Sheppard, D.; Mukouyama, Y.-s.
10.1101/2025.04.15.648984 — pathology — Posted on 2025-04-19
2124 Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles
Bhalotia, A.; Nittayacharn, P.; Mehta, M.; Iyer, A.; Hutchinson, D. W.; Cheplyansky, A.; Takizawa, K.; Nidhiry, A.; Gopalakrishnan, R.; Kosmides, T.; Exner, A. A.; Karathanasis, E.
10.1101/2025.04.13.648512 — bioengineering — Posted on 2025-04-19
2126 Write and read: Harnessing Synthetic DNA Modifications for Nanopore Sequencing.
Bertocchi, U.; Grunwald, A.; Goldner, G.; Eitan, E.; Avraham, S.; Deek, J.; Michaeli, Y.; Yao, B.; Listgarten, J.; Simpson, J. T.; Timp, W.; Ebenstein, Y.
10.1101/2025.04.14.648727 — bioengineering — Posted on 2025-04-19
2128 Establishing Comprehensive Transthoracic Echocardiography Reference Ranges for Mouse Models: Insights into the Impact of Anesthesia, Sex, and Age
Oestereicher, M.; Ward, C.; Schneltzer, E.; Marschall, S.; Fuchs, H.; Gailus-Durner, V.; Bou About, G.; Selloum, M.; Meziane, H.; Stewart, M.; Teboul, L. E.; Norris, C.; Pimm, D.; Kan, M.; Lopez Gomez, F.; Wilson, R.; Monroy, M.; Pasha, S.; Zabrodska, E.; Prochazka, J.; Pajuelo Reguera, D.; Nichtova, Z.; Herault, Y.; Wells, S.; Parkinson, H.; Heaney, J.; Sedlacek, R.; Gao, X.; Hrabe de Angelis, M.; Spielmann, N.
10.1101/2025.04.14.647528 — genetics — Posted on 2025-04-19
2131 Biologically inspired warning patterns deter birds from wind turbines
Hancock, G. R. A.; Lehtonen, H.; Brown, T.; Ejjite, A.; Nokelainen, O.; Mappes, J.; Winters, S.
10.1101/2025.04.14.648692 — ecology — Posted on 2025-04-19
2132 Impacts of high pathogenicity avian influenza H5N1 2.3.4.4b south of the Antarctic Circle
Gorta, S. B. Z.; Neira, V.; Wille, M.; Gajardo, D.; Yılmaz, A.; Oktar, O.; Özsoy, B.; Sekercioglu, C. H.
10.1101/2025.04.13.648652 — ecology — Posted on 2025-04-19
2133 Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition
Zeng, Y.; Zhang, T.; Cornish, E.; Lee, S.-R.; Yam, M.; Eminhizer, M.; Zeng, J.; Zhang, J.; Zeng, S.; Wei, X.; Yang, J.; Zhu, M.; Chang, A.; Zhang, M.; Du, J.; Zhu, L.; Gillies, M. C.
10.1101/2025.04.13.648057 — neuroscience — Posted on 2025-04-19
2134 Advancing Mobile Neuroscience: A Novel Wearable Backpack for Multi-Sensor Research in Urban Environments
Amaro, J.; Ramusga, R.; Bonifacio, A.; Frazao, J.; Almeida, A.; Lopes, G.; Chokhachian, A.; Santucci, D.; Morgado, P.; Miranda, B.
10.1101/2025.04.13.648607 — neuroscience — Posted on 2025-04-19
2140 Generation of a Three-dimensional Human Neurovascular Unit Model in a Microfluidic Chip
Qiu, B.; Pompe, S.; Xenaki, K.; van Bergen en Henegouwen, P. M. P.; Oliveira, S.; Mastrobattista, E.; Caiazzo, M.
10.1101/2025.04.13.648605 — bioengineering — Posted on 2025-04-19
2143 Bacteriophage-host interactions in microgravity aboard the International Space Station
Huss, P.; Chitboonthavisuk, C.; Meger, A.; Nishikawa, K.; Oates, R. P.; Mills, H.; Holzhaus, O.; Raman, S.
10.1101/2023.10.10.561409 — synthetic biology — Posted on 2025-04-19
2144 Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy
Reever, C. M.; Boscia, A. R.; Deutsch, T. C. J.; Patel, M. P.; Miralles, R. M.; Kittur, S.; Fleischel, E. J.; Buo, A. M. L.; Yorek, M. S.; Meisler, M. H.; Farber, C. R.; Patel, M. K.
10.1101/2025.04.09.647983 — bioengineering — Posted on 2025-04-19
2145 Obesity promotes urinary tract infection by disrupting urothelial immune defenses
Schwartz, L.; Salamon, K.; Simoni, A.; Cotzomi-Ortega, I.; Sanchez-Zomora, Y.; Linn-Peirano, S.; John, P.; Ruiz-Rosado, J. d. D.; Jackson, A. R.; Wang, X.; Spencer, J. D.
10.1101/2025.04.04.647270 — cell biology — Posted on 2025-04-19
2149 Revival of traditional agricultural systems A multidisciplinary on-farm survey of maize-bean intercropping reveals unexpected competition effects on beans.
Vazeux-Blumental, N.; Mathieu, L.; Trabac, T.; Palaffre, C.; Lagardere, B.; Carraretto, M.; Bauland, C.; Le Guilloux, M.; Paysant-Le Roux, C.; Caius, J.; Marmagne, A.; Enjalbert, J.; Flutre, T.; Le Cadre, E.; Parnaudeau, V.; Muller, D.; Moenne-Loccoz, Y.; Manicacci, D.; Tenaillon, M. I.
10.1101/2024.04.24.590929 — plant biology — Posted on 2025-04-19
2151 Mosquito sex under lock and key
Houri-Zeevi, L.; Walker, M. M.; Razzauti, J.; Sharma, A.; Pasolli, H. A.; Vosshall, L. B.
10.1101/2025.04.11.648401 — animal behavior and cognition — Posted on 2025-04-19
2156 Bipartite invariance in mouse primary visual cortex
Ding, Z.; Tran, D. T.; Ponder, K.; Ding, Z.; Froebe, R.; Ntanavara, L.; Fahey, P. G.; Cobos, E.; Baroni, L.; Diamantaki, M.; Wang, E.; Chang, A.; Papadopoulos, S.; Fu, J.; Muhammad, T.; Papadopoulos, C.; Cadena, S. A.; Evangelou, A.; Willeke, K.; Anselmi, F.; Sanborn, S.; Antolik, J.; Froudarakis, E.; Patel, S.; Walker, E. Y.; Reimer, J.; Sinz, F. H.; Ecker, A. S.; Franke, K.; Pitkow, X.; Tolias, A. S.
10.1101/2023.03.15.532836 — neuroscience — Posted on 2025-04-19
2158 Developmental, neuroanatomical and cellular expression of genes causing dystonia
Cameron, D.; Clifton, N. E.; de la Fuente, D. C.; Holmans, P.; Bray, N. J.; Peall, K.
10.1101/2025.04.13.648593 — neuroscience — Posted on 2025-04-18
2160 Warning signals for long-term innovative potential of genetic research under commercial pressure
Chae, J.; Kim, W.; Jung, W.; Jeong, D.; Lim, R.; Chamlagain, M.; Jung, G.; Jang, J.; Lee, J. W.; Kang, N. K.; Baek, K.; Shin, J.; Lee, Y.-G.; Koh, H. G.; Kim, C.; Yook, S.; Cheung, A. K. L.; Jin, Y.-S.; Youn, H.; Kim, P.-J.; Ghim, C.-M.
10.1101/2025.02.17.638429 — scientific communication and education — Posted on 2025-04-18
2165 Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice: The Central Nucleus of the Amygdala
Anderson, J. Q.; Darakjian, P.; Hitzemann, R. J.; Cervera-Juanes, R.; Zimmerman, K. D.; Reed, C.; Ozburn, A. R.; Lockwood, D.; Phillips, T. J.
10.1101/2025.04.15.649004 — genomics — Posted on 2025-04-18
2166 Development and validation of KASP markers for a novel powdery mildew resistance gene in wheat using BSR-Seq analysis
Kaur, R.; Tyagi, V.; Dhariwal, R.; Sheikh, I.; Dhaliwal, H. S.; Sivasamy, M.; Sivakumar, T.; Kumar, S.; Ravat, V. K.; Vasistha, N. K.
10.1101/2025.04.12.648525 — genetics — Posted on 2025-04-18
2172 New Δ246p53 isoform responds to DNA damage to enhance p53 functions in senescence and tumour suppression
Parkar, S. N.; Ramalho, A. C.; Lopez-Iniesta, M. J.; Kimura, K.; Zhao, J.; da Silva Rita, F.; Romao, L.; Candeias, M. M.
10.1101/2023.04.07.536059 — cancer biology — Posted on 2025-04-18
2173 AMOEBA Polarizable Molecular Dynamics Simulations of Guanine Quadruplexes: from the c-Kit Proto-oncogene to HIV-1
El Ahdab, D. S.; Lagardere, L.; Hobaika, Z.; Jaffrelot Inizan, T.; Celerse, F.; Gresh, N.; Maroun, R. G.; Piquemal, J.-P.
10.1101/2024.08.28.610081 — biophysics — Posted on 2025-04-18
2174 Stress anisotropy in 3D active curved structures
Lou, Y.; Theis, S.; Rupprecht, J. F.; Saunders, T. E.; Hiraiwa, T.
10.1101/2025.04.13.648577 — biophysics — Posted on 2025-04-18
2177 One-click image reconstruction in single-molecule localization microscopy via deep learning
Saguy, A.; Xiao, D.; Narayanasamy, K. K.; Nakatani, Y.; Gustavsson, A.-K.; Heilemann, M.; Shechtman, Y.
10.1101/2025.04.13.648574 — bioengineering — Posted on 2025-04-18
2179 High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-specific Protease USP18
Kooij, R.; Pol, V.; Gan, J.; van Doodewaerd, B.; Sapmaz, A.; Fritz, G.; Knobeloch, K.-P.; Geurink, P. P.
10.1101/2025.04.18.649523 — biochemistry — Posted on 2025-04-18
2180 Local Genetic Sex Differences in Quantitative Traits
Uffelmann, E.; de Leeuw, C.; Schipper, M.; Posthuma, D.
10.1101/2023.05.04.539410 — genetics — Posted on 2025-04-18
2183 Translation Accuracy in E. coli
Stikeleather, R.; Ali, F.; Ho, W.-C.; Licknack, T.; Lynch, M.
10.1101/2025.04.18.649569 — evolutionary biology — Posted on 2025-04-18
2185 Modeling control of invasive fire ants by gene drive
Liu, Y.; Champer, S. E.; Haller, B. C.; Champer, J.
10.1101/2025.03.04.641467 — ecology — Posted on 2025-04-18
2186 Recombination alters the furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus
Yeh, T.-Y.; Tsai, V.; Liao, S. M.; Hong, C.-E.; Kuo, F.-Y.; Wang, Y. C.; Feehley, M. C.; Feehley, P. J.; Lai, Y.-C.; Contreras, G. P.
10.1101/2025.04.17.649446 — microbiology — Posted on 2025-04-18
2187 Cooperation Between Genotoxic Bacteria Accelerates Tumorigenesis in a Mouse Model of Colon Carcinogenesis
Plitt, T.; Piessevaux, A.; Rajpal, U.; Fisher, J.; Spindler, M. P.; Li, Z.; Mogno, I.; Yang, Y.; Desch, A. N.; Chu, G.; Jiang, Z.; Wang, J.; Gevers, D.; Pocalyko, D.; Geis, A. L.; Jobin, C.; Bachman, K. E.; Sears, C. L.; Britton, G. J.; San Mateo, L. R.; Faith, J.
10.1101/2025.04.18.649375 — microbiology — Posted on 2025-04-18
2190 Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
Glaser, A.; Chandrashekar, J.; Vasquez, S.; Arshadi, C.; Javeri, R.; Ouellette, N.; Jiang, X.; Baka, J.; Kovacs, G.; Woodard, M.; Seshamani, S.; Cao, K.; Clack, N.; Recknagel, A.; Grim, A.; Balaram, P.; Turschak, E.; Hooper, M.; Liddell, A.; Rohde, J.; Hellevik, A.; Takasaki, K.; Erion Barner, L.; Logsdon, M.; Chronopoulos, C.; de Vries, S.; Ting, J.; Perlmutter, S.; Kalmbach, B.; Dembrow, N.; Tasic, B.; Reid, R. C.; Feng, D.; Svoboda, K.
10.1101/2023.06.08.544277 — neuroscience — Posted on 2025-04-18
2191 Neural and Behavioral Changes in Older Adults from Auditory-Cognitive Training
Fisher, C.; Karunathilake, I. M. D.; Johns, M. A.; Vance, A.; Kuchinsky, S. E.; Anderson, S.; Simon, J. Z.
10.1101/2025.04.01.646593 — neuroscience — Posted on 2025-04-18
2192 Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden
Michael, C. T.; Budak, M.; Maiello, P.; Kracinovsky, K.; Rodgers, M.; Tomko, J.; Lin, P. L.; Flynn, J. L.; Linderman, J. J.; Kirschner, D.
10.1101/2025.04.10.648004 — systems biology — Posted on 2025-04-18
2193 Global Skeletal Muscle Metabolomics Reveals Mechanisms Behind Higher Response to Resistance Training in Older Adults
Lim, C.; Lixandrao, M.; Trivedi, D.; Xu, Y.; Prokopidis, K.; Roschel, H.; Phillips, S. M.; Muhamadali, H.; Isanejad, M.
10.1101/2025.03.13.642876 — systems biology — Posted on 2025-04-18
2195 Metabolite profiling reveals slow and uncoordinated adjustment of C4 photosynthesis to sudden changes in irradiance
Arrivault, S.; Medeiros, D. B.; Sales, C. R. G.; Guenther, M.; Kromdijk, J.; Fernie, A. R.; Stitt, M.
10.1101/2025.04.13.648559 — plant biology — Posted on 2025-04-18
2197 Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers
Kretsch, R. C.; Albrecht, R.; Andersen, E. S.; Chen, H.-A.; Chiu, W.; Das, R.; Gezelle, J. G.; Hartmann, M. D.; Hobartner, C.; Hu, Y.; Jadhav, S.; Johnson, P. E.; Jones, C. P.; Koirala, D.; Kristoffersen, E. L.; Largy, E.; Lewicka, A.; Mackereth, C. D.; Marcia, M.; Nigro, M.; Ojha, M.; Piccirilli, J. A.; Rice, P. A.; Shin, H.; Steckelberg, A.-L.; Su, Z.; Srivastava, Y.; Wang, L.; Wu, Y.; Xie, J.; Zwergius, N. H.; Moult, J.; Kryshtafovych, A.
10.1101/2025.04.15.649049 — biophysics — Posted on 2025-04-18
2200 Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights from 13C and 1H Solid-State NMR
Ankur, A.; Yarava, J. R.; Gautam, I.; Scott, F.; Mentink-Vigier, F.; Chrissian, C.; Xie, L.; Roy, D.; Stark, R. E.; Doering, T.; Wang, P.; Wang, T.
10.1101/2025.04.18.649559 — biochemistry — Posted on 2025-04-18
2203 Application of a French cattle pangenome, from structural variant discovery to association studies on key phenotypes
Sorin, V.; Naji, M.-M.; Birbes, C.; Grohs, C.; Escouflaire, C.; Fritz, S.; Eche, C.; Marcuzzo, C.; Suin, A.; Donnadieu, C.; Gaspin, C.; Iampietro, C.; Milan, D.; Drouilhet, L.; Tosser-Klopp, G.; Boichard, D.; Klopp, C.; Sanchez, M.-P.; Boussaha, M.
10.1101/2025.04.15.648672 — genetics — Posted on 2025-04-18
2204 Transcriptomic bases of within- and trans-generational predator-induced plasticity in the freshwater snail Physa acuta
Dejeux, L.; Saclier, N.; Tariel-Adam, J.; Hoareau, M.; Lefebure, T.; Konecny, L.; Plenet, S.; Luquet, E.
10.1101/2024.10.16.618730 — evolutionary biology — Posted on 2025-04-18
2205 Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer
Mossner, M.; Colson, C.; Guo, Q.; Whiting, F.; Grant, H.; Stafford, A.; Kyle, P.; Donato-Brown, D.; Murphy, J.; Sottoriva, A.; Baker, A.-M.; Graham, T.
10.1101/2025.04.15.648959 — molecular biology — Posted on 2025-04-18
2210 Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones.
Turner, C. T.; Tiffeau-Mayer, A.; Rosenheim, J.; Chandran, A.; Saxena, R.; Zhang, P.; Jiang, J.; Berkeley, M.; Pang, F.; Uddin, I.; Nageswaran, G.; Byrne, S.; Karthikeyan, A.; Smidt, W.; Ogongo, P.; Byng-Maddick, R.; Capocci, S.; Lipman, M.; Kunst, H.; Lozewicz, S.; Rasmussen, V.; Pollara, G.; Knight, J. C.; Leslie, A.; Chain, B. M.; Noursadeghi, M.
10.1101/2025.04.12.648537 — immunology — Posted on 2025-04-18
2212 N1 cassette-lacking NMDA receptors mediate the antidepressant activity of ketamine
He, A. T.; Zhang, W.; Li, H.; Tu, Y.; Lee, D.; Kim, D.; Jia, Z.; Wang, L.-Y.; SALTER, M. W.
10.1101/2025.04.12.648536 — neuroscience — Posted on 2025-04-18
2213 Statistical Molecular Interaction Fields: A Fast andInformative Tool for Characterizing RNA and ProteinBinding Pockets
Barquero Morera, D.; Mattiotti, G.; Kocev, A.; Rousselot, A.; Rouaud, L.; santuz, H.; Baaden, M.; Taly, A.; Pasquali, S.
10.1101/2025.04.16.649117 — biophysics — Posted on 2025-04-18
2214 SM3DD with Segmented PCA: A Comprehensive Method for Interpreting 3D Spatial Transcriptomics
Blick, T.; Kilgallon, A.; Monkman, J.; Cooper, C.; Tan, C. W.; Killingbeck, E.; Pan, L.; Kim, Y.; Liang, Y.; Nam, A.; Leon, M.; Souza-Fonseca-Guimaraes, P.; Seigo Nagashima, S.; Martins, A. P. C.; Machado-Souza, C.; De Noronha, L.; Fraser, J. F.; Belz, G.; Souza-Fonseca-Guimaraes, F.; Kulasinghe, A.
10.1101/2025.04.17.649456 — bioinformatics — Posted on 2025-04-18
2216 Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle
Fan, Y.; De Silva, S.; Tabassum, N. I.; Peng, X.; Lim, V.; Cheng, X.; Datta, K. K.; Lowe, R.; Johns, T. G.; Mattson, M. P.; Mathivanan, S.; Sobey, C. G.; Okun, E.; Liu, Y. U.; Chen, G.; Lai, M. K. P.; Jo, D.-G.; Gunaratne, J.; Arumugam, T. V.
10.1101/2025.04.13.648650 — molecular biology — Posted on 2025-04-18
2217 Sustained cross-species transmission of gammacoronavirus in wild birds reveled by viral characterization in China
Wang, D.-S.; Zou, Y.-Y.; Liu, Q.; Huang, H.; Han, P.-Y.; Zhao, J.-Y.; Zong, L.-D.; Qiu, Y.; Zhang, Y.-Z.; Ge, X.-Y.
10.1101/2025.04.17.648926 — microbiology — Posted on 2025-04-18
2221 High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal Adenocarcinoma
Greene, E.; Horvat, N. K.; Doxie, D. B.; Parihar, V. C.; Kim, J.; Herting, C. J.; Grundy, E. E.; Ruffin, A. T.; Krasinskas, A. M.; Maithel, S. K.; Sarmiento, J. M.; Shah, M. M.; Zaidi, M. Y.; Diab, M.; Alese, O. B.; Dhodapkar, K.; Kissick, H. T.; El-Rayes, B. F.; Paulos, C. M.; Lesinski, G. B.
10.1101/2025.04.18.649381 — cancer biology — Posted on 2025-04-18
2222 Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth
Birge, R. B.; Gadiyar, V.; Pulica, R.; Aquib, A.; Tranos, J. A.; Varsanyi, C.; Almansa, L. F.; Gaspers, L.; De Lorenzo, M.; Kotenko, S. V.; Tripathi, S.; Howell, R. W.; Choudhary, A.; Calianese, D. C.
10.1101/2025.04.17.649445 — cancer biology — Posted on 2025-04-18
2223 Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum
Ng, D.; Kazazian, K.; Lee, K.; Lu, Y. Q.; Ali, A.; Pacholczyk, K.; Brar, S.; Conner, J.; Jurisica, I.; McCulloch, C. A.; Kim, D.-K.; Swallow, C. J.; Magalhaes, M.
10.1101/2025.04.14.648628 — cancer biology — Posted on 2025-04-18
2224 Prediction of Outcome from Spatial Protein Profiling of Triple-Negative Breast Cancers
Foroughi pour, A.; Wu, T.-c.; Martinek, J.; Sivajothi, S.; Robson, P.; Palucka, K.; Chuang, J. H.
10.1101/2025.04.18.649541 — cancer biology — Posted on 2025-04-18
2226 KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma
Meilerman Abuelafia, A.; Santofimia-Castano, P.; Estaras, M.; Grasso, D.; Chuluyan, E.; Lomberk, G.; Urrutia, R.; Dusetti, N.; Fraunhoffer, N.; Iovanna, J.
10.1101/2025.04.13.648164 — cancer biology — Posted on 2025-04-18
2230 A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity
Rao, D. S.; Jaiswal, A. K.; Scherer, G. M.; Thaxton, M.; Sorrentino, J.; Yuen, C.; Mehta, M.; SHARMA, G.; Lin, T. L.; Tran, T.; Cohen, A.; Ritters, A. J.; Kotecha, R.; Sanford, J.; Damoiseaux, R.; Garg, N.
10.1101/2025.04.14.648780 — cancer biology — Posted on 2025-04-18
2232 MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer
Bayley, R.; Munsey, A.; Ahmed, S.; Ward, C.; Stiby, A.; Briantseva, B.-M.; Jawanda, K.; Shaaban, A. M.; Saponaro, M.; Smith, G. C. M.; Clarke, R. B.; Davies, C.; Garcia, P.
10.1101/2025.04.15.648875 — cancer biology — Posted on 2025-04-18
2234 Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy
Ahad, A.; Leng, F.; Ichise, H.; Schrom, E.; Yang, L.; So, J. Y.; Sellner, C.; Gu, Y.; Wang, W.; Kieu, C.; Park, W.; Yang, R.; Wolcott, K.; Livak, F.; Kruhlak, M.; Aprelikova, O.; Gray, J.; Koparde, V.; Moriwaki, Y.; Germain, R.
10.1101/2025.04.16.649000 — cancer biology — Posted on 2025-04-18
2235 Cell-Based Potency Assay for Anti-CD3-Anti-CD19 Diabody
Weiss, T. L.; Paniagua, J.; Johnson, T. M.; Cripe, T. P.; Ralph, P.
10.1101/2025.04.15.648836 — cancer biology — Posted on 2025-04-18
2236 A Computational Framework for Analysis of cfDNA Fragmentation Profiles
Poh, Z. W.; Zhu, G.; Wong, P. M.; Odinokov, D.; Carrie, H.; Lau, Y. T.; Gan, A.; Poon, P.; Tan, P.; Jacobsen Skanderup, A.; Tan, I.
10.1101/2025.04.17.649313 — cancer biology — Posted on 2025-04-18
2237 A microRNA CRISPR screen reveals miR-483-3p as an apoptotic regulator in prostate cancer
Chow, J. T.-S.; Desjardins, A.; Lee, D. K. C.; Grigore, I. A.; Fu, N. J.; Chau, S.; Lee, B. Y.; Gabra, M. M.; Salmena, L.
10.1101/2025.04.16.649147 — cancer biology — Posted on 2025-04-18
2238 Exploring the Anti-Tumor Effects of Brusatol in Aggressive B-Cell Lymphomas
Szmyra-Polomka, M. M.; Haingartner, S.; Jantscher, S.; Bernhart, E. M.; Kovacs-Hajdu, P.; Boskova, V.; Krall, N.; Zupo, A.; Pircher, T.; Pansy, K.; Kloesch, B.; Greinix, H. T.; Beham-Schmid, C.; Vagena, F. R.; Zacharias, M.; Gaksch, L.; Prochazka, K.; Neumeister, P.; Dengler, M. A.; Deutsch, A. J.
10.1101/2025.04.16.649058 — cancer biology — Posted on 2025-04-18
2239 Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in BAP1mut uveal melanoma
Brosens, E.; Nguyen, J.; Konemann, N.; van den Bosch, T.; Verdijk, R.; Kilic, E.; van den Bosch, Q.
10.1101/2025.04.14.648661 — cancer biology — Posted on 2025-04-18
2240 Oncogene Silencing via ecDNA Micronucleation
Brueckner, L.; Xu, R.; Tang, J.; Herrmann, A.; Wong, I. T.-L.; Zhang, S.; Tu, F.; Pilon, M.; Kukalev, A.; Pardon, K.; Sidorova, O.; Atta, J.; Yu, Q.; Pradella, D.; Ilic, M.; Novais-Cruz, M.; Kaltenbach, S.; Treue, D.; Giurgiu, M.; Herzog, S.; Hollinger, A.-S.; Fernandez, M.; Becker, F.; Louma, V.-R.; Schmargon, R.; Doerr, J.; Gamlin, D.; Lehmann, A.; Guergen, D.; Richter, M.; Dubois, F.; Simeoni, F.; Pennycook, B. R.; Hamilton, A.; Lindemann, R. K.; Fischer, M.; Bafna, V.; Wahl, G.; Koche, R. P.; Chang, H. Y.; Papathanasiou, S.; Medema, R.; Spanjaard, B.; Ventura, A.; Pombo, A.; Huang, W.; Wer
10.1101/2025.04.15.648906 — cancer biology — Posted on 2025-04-18
2241 A unified eIF1A+ luminal cells-centered hypoxic and "cold" tumor microenvironment promotes PCa progression among different subtypes
Wan, L.; Huang, E.; Xu, Z.; Zheng, B.; Ding, X.; Chu, C.; Wu, T.; Chen, S.; Zhuang, J.; Chen, M.; Na, R.; Ju, S.; Zhang, D.; Li, W.; Cheng, Y.; Xu, B.
10.1101/2025.04.17.649316 — cancer biology — Posted on 2025-04-18
2242 CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
Watterson, A.; Picco, G.; Veninga, V.; Samarakoon, Y.; Cattaneo, C. M.; Vieira, S. F.; Karakoc, E.; Bhosle, S.; Battaglia, T. W.; Consonni, S.; Halim, T. Y. F.; Voest, E. E.; Garnett, M. J.; Coelho, M. A.
10.1101/2025.04.15.648737 — cancer biology — Posted on 2025-04-18
2243 SKIDA1 transiently sustains MLL::ENL-Expressing hematopoietic progenitors during neonatal stages and promotes B-lineage priming
Mendoza-Castrejon, J.; Yang, W.; Denby, E.; Muthukumar, R.; Casey, E. B.; Patel, R. M.; Tasian, S. K.; Magee, J. A.
10.1101/2025.04.12.648529 — cancer biology — Posted on 2025-04-18
2244 Nucleotide insufficiency induced by p53 deficiency leads to replication stress driving genomic instability
Zaatra, W.; Philippos, G.; Smirnov, P.; Cochavi, S. M.; Otonicar, J.; Chan, M.; Harel, M.; Devens, F.; Eliassaf, A.; Grimes, K.; Irony-Tur Sinai, M.; Sigismondo, G.; Gieiger, T.; Korbel, J.; Krijgsveld, J.; Shalev, O.; Kerem, B.; Ernst, A.
10.1101/2025.04.17.649416 — cancer biology — Posted on 2025-04-18
2245 KDM5B expression is suppressed by MYC in a negative feedback loop to promote cell survival.
Chatterjee, T.; Beffert, E.; Dewson, G. S.; Sullivan, D. K.; Anchang, B.; Sears, R. C.; Liefwalker, D.
10.1101/2025.04.12.648490 — cancer biology — Posted on 2025-04-18
2248 CLM296: a highly selective inhibitor targeting ALDH1A3-driven tumor growth and metastasis in breast cancer
MacLean, M. R.; Bernardoni, B. L.; Fernando, W.; Petrarolo, G.; D Agostino, I.; Dean, C. A.; Venkatesh, J.; Hughes, C. S.; Goralski, K.; Subramanian, G.; Arun, R. P.; Cahill, H. F.; Walker, O.; La Motta, C.; Marcato, P.
10.1101/2025.04.16.649105 — cancer biology — Posted on 2025-04-18
2249 WITHDRAWN: Genomics and reproductive biology of Leptopilina malgretoutensis Buffington, Lue, Davis & Tracey sp. nov. (Hymenoptera: Figitidae): An asexual parasitoid of Caribbean Drosophila
Lindsey, A. R.; Lue, C.-H.; Davis, J. S.; Borjon, L. J.; Mauthner, S. E.; Fricke, L. C.; Eads, L.; Murphy, M.; Drown, M. K.; Faulk, C.; Buffington, M. L.; Tracey, W. D.
10.1101/2025.03.28.645512 — evolutionary biology — Posted on 2025-04-18
2256 Spatial differentiation of proteome in cervical cancer tissues using Imaging Mass Spectrometry
Baliyan, A.; Mohapatra, I.; Paul, S.; Safiriyu, A. A.; Mondal, S. K.; Mishra, D.; Mandal, A. K.
10.1101/2025.04.12.648495 — cancer biology — Posted on 2025-04-18
2257 Microglial Fructose Metabolism Is Essential for Glioblastoma Growth
Billingham, L. K.; Delay, S. L.; Tripathi, S.; Olson, I. E.; Zilinger, K.; Subbiah, J.; Wang, Z.; Sadagopan, N. S.; Chia, T.-Y.; Najem, H.; Cognet, G.; Katz, J. L.; Vazquez-Cervantes, G. I.; Wang, S.; Wan, H.; Murphy, A. R.; Lipshutz, A. B.; Duffy, J. T.; Valyasnikova, I. V.; Zhang, P.; Heiland, D. H.; Ahmed, A. U.; Lee-Chang, C.; Heimberger, A. B.; Perry, J. S.; Muir, A.; Chandel, N. S.; Miska, J.
10.1101/2025.04.12.646414 — cancer biology — Posted on 2025-04-18
2258 Whole-genome prediction of bacterial pathogenic capacity on novel bacteria using protein language models, with PathogenFinder2
Ferrer Florensa, A.; Almagro Armenteros, J. J.; Kaas, R. S.; Clausen, P. T.; Nielsen, H.; Rost, B.; Aarestrup, F. M.
10.1101/2025.04.12.648497 — bioinformatics — Posted on 2025-04-18
2263 Discovery of D2469079A, A novel selective Toll-Like Receptor 7/8 Antagonist with Brain Penetrance
Deng, X.; Zhang, X.; Tian, W.; Xiao, D.; Du, Z.; Wang, Y.; Cao, S.; Li, B.; Zhao, Y.; Chen, H.; Su, Y.; Zhou, Y.
10.1101/2025.04.12.648517 — immunology — Posted on 2025-04-18
2264 Selective decoupling of IgG1 binding to viral Fc receptorsrestores antibody-mediated NK cell activation against HCMV-infected cells
Qerqez, A. N.; Hoffmann, K.; Lee, A. G.; Pareek, S.; Hager, K. M.; Mishra, A. K.; Delidakis, G.; Bentley, K.; Kerr-Jones, L.; Cabrera, M.; Nguyen, T.; Goettler, R. L.; Chowdhury, A.; Kolb, P.; Hengel, H.; Georgiou, G.; McLellan, J. S.; Stanton, R.; Nguyen, A. W.; Maynard, J. A.
10.1101/2025.04.12.647817 — immunology — Posted on 2025-04-18
2265 Task-induced 1/f slope modulation as a paradigm-independent marker of cognitive control in multiple sclerosis
Akbarian, F.; Gyurkovics, M.; Dhooghe, M. B.; Dhaeseleer, M.; Nagels, G.; Van Schependom, J.
10.1101/2025.04.11.648423 — neuroscience — Posted on 2025-04-18
2270 DICAR-JP Regulates Ribosome Migration, a New Theory of Mitochondrial Protein Production
Zhang, J.; Yu, X.; Zheng, S.; Qiao, G.; Zhang, C.; Tang, S.; Gao, X.; Wang, Y.; Yu, Y.; Cheng, J.; Lei, M.; Li, P.; Yang, Y.; Zhang, C.; Yuan, Q.
10.1101/2025.04.11.648480 — pharmacology and toxicology — Posted on 2025-04-18
2271 Generating the head direction signal: Two types of head direction cells in the lateral mammillary and dorsal tegmental nuclei.
Taube, J. S.; Butler, W. M.; Dumont, J. R.; Graham, J. A.; Marcroft, J. L.; Shinder, M. E.; Stackman, R. W.; Yoder, R. M.
10.1101/2025.04.11.648409 — neuroscience — Posted on 2025-04-18
2272 Identifying non-coding variant effects at scale via machine learning models of cis-regulatory reporter assays
Butts, J. C.; Rong, S.; Gosai, S. J.; Castro, R. I.; Noon, M.; Adeniran, K.; Ghosh, R.; Sabeti, P. C.; Tewhey, R.; Reilly, S. K.
10.1101/2025.04.16.648420 — genomics — Posted on 2025-04-18
2275 Parasite virulence in coinfected hosts: the importance of infection order
Sorci, G.; Dusuel, A.; Bourbon, L.; Groetz, E.; Pernet, N.; Rialland, M.; Roche, B.; Faivre, B.
10.1101/2025.03.13.642968 — evolutionary biology — Posted on 2025-04-18
2277 Exploiting functional regions in the viral RNA genome as druggable entities
Luo, D.; Zheng, Y.; Huang, Z.; Wen, Z.; Guo, L.; Deng, Y.; Li, Q.; Bai, Y.; Haider, S.; Wei, D.
10.1101/2024.08.11.607475 — genomics — Posted on 2025-04-18
2278 The evolution of gene expression in seasonal environments
Kudo, S. N.; Ikezaki, Y.; Kusumi, J.; Hirakawa, H.; Isobe, S.; Satake, A.
10.1101/2025.03.25.645377 — evolutionary biology — Posted on 2025-04-18
2279 Investigating the determinants of performance in machine learning for protein fitness prediction
Sandhu, M.; Mater, A. C.; Matthews, D. S.; Spence, M. A.; Lenskiy, A. A.; Jackson, C. J.
10.1101/2020.09.30.319780 — synthetic biology — Posted on 2025-04-18
2280 Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities
Hayes, V. M.; Craddock, J.; Lutsik, P.; Soh, P.; Louw, M.; Hasan, M. M.; Patrick, S.; Mutambirwa, S.; Stricker, P.; Förtsch, H.; Bornman, M. R.; Gerhauser, C.
10.1101/2025.04.16.649098 — genomics — Posted on 2025-04-18
2282 RBMX2: A Pivotal Regulator Linking Mycobacterium bovis Infection to Epithelial-Mesenchymal Transition and Lung Cancer Progression
Wang, C.; Peng, Y.; Yang, H.; Jiang, Y.; Khalid, A. K.; Zhang, K.; Xie, S.; Bermudez, L.; Yang, Y.; Zhang, L.; Chen, H.; Guo, A.; Chen, Y.
10.1101/2025.04.15.648920 — microbiology — Posted on 2025-04-18
2288 Balancing nutrient remobilization and photosynthesis: the dual role of lupin cotyledons after germination
Angermann, C.; Heinemann, B.; Bueno Nogueira, B.; Mai, H.-J.; Bauer, P.; Hildebrandt, T. M.
10.1101/2025.04.15.648908 — plant biology — Posted on 2025-04-18
2290 INDETERMINATE DOMAIN-DELLA protein interactions orchestrate gibberellin-mediated cell elongation in wheat and barley
Sokolowska, P.; Jost, M.; Buss, W.; Ford, B.; Chandler, P.; Spielmeyer, W.; Phillips, A.; Huttly, A.; Tarkowska, D.; Alarcon-Reverte, R.; Clark, S.; Pearce, S.; Hedden, P.; Thomas, S.
10.1101/2025.04.17.649374 — plant biology — Posted on 2025-04-18
2296 Multiple instances of river-lake introgression in the adaptive radiation of sailfin silversides in Wallace's Dreampond
De Keyzer, E. L. R.; Herder, F.; Boehne, A.; Campuzano Jimenez, F.; Burskaia, V.; Kukowka, S.; Tracey, A.; Denton, A. L.; Oatley, G.; Tree of Life programme, ; Scientific Operations: DNA Pipelines collective, ; Core Informatics collective, ; Mokodongan, D. F.; Wowor, D.; Svardal, H.
10.1101/2025.04.16.648611 — evolutionary biology — Posted on 2025-04-18
2299 Innovative airborne DNA approach for monitoring honey bee foraging and health
Pepinelli, M.; Biganzoli-Rangel, A. J.; Lunn, K.; Arteaga, P.; Borges, D.; Zayed, A.; Clare, E.
10.1101/2025.04.17.649222 — ecology — Posted on 2025-04-18
2300 Dating and quantifying past gene flow due to hybridization events in Iberian chubs
Faustino, E.; Mendes, S. L.; Carvalho, J.; Perea, S.; Doadrio, I.; Feulner, P. G. D.; Sousa Santos, C.; Sousa, V. C.
10.1101/2025.04.13.648569 — evolutionary biology — Posted on 2025-04-17
2301 Sub-optimal temperature leads to tighter coupling between photosynthetic electron transport and CO2 assimilation under fluctuating light in maize.
Rodrigues Gabriel Sales, C.; Arrivault, S.; Tonetti, T.; Clapero, V.; Vath, R. L.; Cubas, L. A.; Stitt, M.; Kromdijk, J.
10.1101/2025.04.12.648513 — plant biology — Posted on 2025-04-17
2302 Expression levels of the Band-7 protein FLOTILLIN modulate salt tolerance, growth and development in the moss Physcomitrium patens
Csicsely, E.; Noor, N.; Mühlbauer, S.; Kunz, H.-H.; Schwenkert, S.; Lehmann, M.; Klingl, A.; Top, O.; Frank, W.
10.1101/2025.04.14.648360 — plant biology — Posted on 2025-04-17
2304 Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene, FOXG1
Ramamurthy, A.; Bandouil, M. D.; Aluru, L.; Yoon, E.; Bodkin, N.; Cheng, J. Z.; Biar, C. G.; Calhoun, J. D.; Carvill, G. L.
10.1101/2025.04.11.648472 — genetics — Posted on 2025-04-17
2305 Tracing the evolution of prestin's area-motor activity through ancestral sequence reconstruction and structural modeling
Fuentes-Ugarte, N.; Ruiz-Rojas, T.; Ruiz-Fernandez, A.; Garate, J. A.; Castro-Fernandez, V.; Araya-Secchi, R.
10.1101/2025.04.11.648445 — evolutionary biology — Posted on 2025-04-17
2310 Gastrointestinal colonization as a source of Staphylococcus aureus in atopic dermatitis
Karagounis, T. K.; Putzel, G.; Podkowik, M.; Shenderovich, J.; Tillman, A.; Morales, S. M.; Gaylord, A.; Srivastava, A.; Arguelles, N.; Slater, H.; Ahmed, A. N.; Xing, Y.; Samhadaneh, N. M.; Needle, C. D.; Ulrich, R. J.; Oza, V.; Schluter, J.; Naik, S.; Trasande, L.; Pironti, A.; Torres, V. J.; Shopsin, B.
10.1101/2025.04.17.648849 — microbiology — Posted on 2025-04-17
2311 Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation
Al Maghribi, A.; Rempe, M. J.; Medina, E.; Ford, K. E.; Singletary, K. G.; Ottaway, C.; Peixoto, L.
10.1101/2025.04.16.649209 — neuroscience — Posted on 2025-04-17
2312 Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered afterstroke
Won, S. J.; Uruk, G.; Mai, N.; Tu, C.-L.; Ogut, D.; Asatryan, S.; Mocanu, E.; Shon, R.; Kim, K.; Awakoaiye, K.; Arkelius, K.; Chang, W.; Singhal, N. S.; Swanson, R. A.
10.1101/2025.04.11.648425 — neuroscience — Posted on 2025-04-17
2313 Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering
Hiefinger, C.; Marcon, M.; Pape, V.; Casadevall, G.; Lahmy, R.; Nazet, J.; Bartl, M.; Bruckmann, A.; Osuna, S.; Koenig, B.; Hupfeld, A.
10.1101/2025.04.17.649278 — synthetic biology — Posted on 2025-04-17
2319 DSSP 4: FAIR annotation of protein secondary structure
Hekkelman, M. L.; Alvarez Salmoral, D.; Perrakis, A.; Joosten, R. P.
10.1101/2025.04.11.648460 — bioinformatics — Posted on 2025-04-17
2322 amr.watch - monitoring antimicrobial resistance trends from global genomics data
David, S.; Diaz Caballero, J.; Couto, N.; Abudahab, K.; Fareed-Alikhan, N.; Yeats, C.; Underwood, A.; Molloy, A.; Connor, D.; Shane, H. M.; Ashton, P. M.; Grundmann, H.; Holden, M. T.; Feil, E. J.; Sia, S. B.; Donado-Godoy, P.; Lingegowda, R. K.; Okeke, I. N.; Argimon, S.; Aanensen, D. M.; NIHR Global Health Research Unit on Genomics and enabling data for the Surveillance of AMR,
10.1101/2025.04.17.649298 — genomics — Posted on 2025-04-17
2324 Intercellular communication in the fern endosymbiotic cyanobacterium Nostoc azollae
Sarasa-Buisan, C.; Nieves-Morion, M.; Lindblad, P.; Nierzwicki-Bauer, S.; Schluepmann, H.; Flores, E.
10.1101/2025.04.17.649285 — microbiology — Posted on 2025-04-17
2325 Harmful algal bloom species Microcystis aeruginosa releases thiamin antivitamins to suppress competitors
YAZDANI, M.; Suffridge, C.; Liu, F.; Costello, C. M.; Zhou, Z.; St. John, G.; Bhawal, R.; Zhang, S.; Coates, G.; Wu, M.; Ahner, B.
10.1101/2025.04.17.649140 — microbiology — Posted on 2025-04-17
2330 Protective effects of central leptin on whole-body energy homeostasis upon acute olanzapine exposure
Asgariroozbehani, R.; Singh, R.; Wu, S.; Imami, A. S.; Hamoud, A.-r.; Agarwal, S. M.; Baranowski, B. J.; Jeromson, S.; Bernardo, A.; Prevot, T. D.; Wright, D. C.; Giacca, A.; Mccullumsmith, R. E.; Pereira, S.; Hahn, M. K.
10.1101/2025.04.11.648424 — neuroscience — Posted on 2025-04-17
2331 Targeted gene transfer into developmentally defined cell populations of the primate brain
Ribeiro Gomes, A. R.; Hamel, N.; Mastwal, S.; Wright, N.; Ide, D. C.; Richie, C. T.; Usdin, T. B.; Wang, K. H.; Leopold, D. A.
10.1101/2025.04.11.648413 — neuroscience — Posted on 2025-04-17
2335 A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade
Latham, S. L.; O'Donnell, Y. E.; Girgis-Cook, O.; Clearwater, M. S.; Bryce, N. S.; Mok, E.; Lynn, S. A.; Ni, J.; Alfred, S.; Leong, K. H.; Quek, L.-e.; Murphy, K.; Pantarelli, C.; Dragutinovic, I.; Naeini, M.; Thiel, C.; Cadell, A.; Phimmachanh, M.; Sharma, R.; Millar, E.; Han, J. Z.; Hastings, J. F.; Koehler, M.; Brummer, T.; Young, A.; O'Toole, S.; Oakes, S.; Hardeman, E.; Lock, J.; Kolch, W.; Taft, M. H.; Nobis, M.; Goldstein, L.; Timpson, P.; Parker, B. L.; Holst, J.; Gunning, P. W.; Cox, T. R.; Morris, J. C.; Croucher, D. R.
10.1101/2025.04.16.649243 — cancer biology — Posted on 2025-04-17
2336 Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency
Young, D.; Aguilan, J.; Cutler, R.; Stransky, S.; DeAngelo, J.; Roth, J.; Malachowska, B.; Vercellino, J.; Bell, B.; Shechter, D.; Tofilon, P.; Phillips, R.; Guha, C.; Sidoli, S.
10.1101/2025.04.11.647869 — cancer biology — Posted on 2025-04-17
2339 Efficient near telomere-to-telomere assembly of Nanopore Simplex reads
Cheng, H.; Qu, H.; McKenzie, S.; Lawrence, K. R.; Windsor, R.; Vella, M.; Park, P. J.; Li, H.
10.1101/2025.04.14.648685 — bioinformatics — Posted on 2025-04-17
2345 High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Imai, S.; Hario, S.; Suerte, C.; Yamaguchi, I.; Sakoi, K.; Terai, T.; Takahashi-Yamashiro, K.; Campbell, R. E.
10.1101/2025.04.17.649293 — molecular biology — Posted on 2025-04-17
2346 Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence
Ye, C.; Ezzatpour, S.; Imbiakha, B.; Jackson, N.; Cagatay, T.; Cupic, A.; Miorin, L.; Choi, A.; Buchholz, D. W.; Carter, J.; Sahler, J.; Olarte-Castillo, X. A.; Jager, M. C.; Whittaker, G. R.; August, A.; Fontoura, B.; Garcia-Sastre, A.; Martinez-Sobrido, L.; Aguilar, H. C.
10.1101/2025.04.16.649178 — microbiology — Posted on 2025-04-17
2348 ZFT is the major iron and zinc transporter in Toxoplasma gondii
Aghabi, D.; Gallego Rubio, C.; Cortijo Martinez, M.; Pouzache, A.; Gibson, E. J.; Pagura, L.; Harding, C. R.
10.1101/2025.04.17.649150 — microbiology — Posted on 2025-04-17
2349 Ex vivo recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human Lymphoid Follicle Chip platform
Zhai, Y.; Ku, M. W.; Yang, K.; Patil, A.; Prabhala, P.; He, L.; Man, Y.; Spörri, S. B.; Gharpure, S.; Isaacs, A. R.; Ferdosi, S.; Pitek, A.; Maruggi, G.; Bertholet, S.; Firestone, J.; Mousavi, K.; Miller, E.; Luisi, K.; Hellman, C. A.; Williams, L. D.; Tomaras, G. D.; Yin, P.; Gygi, S.; McAuliffe, J.; Ingber, D. E.; Goyal, G.
10.1101/2025.04.16.649172 — immunology — Posted on 2025-04-17
2350 15-PGDH inhibition promotes hematopoietic recovery and enhances HSC function during aging
Chaudhary, R.; Cordova, B. A.; Hong, M.; Klein, B. R.; Contreras, L. A.; Rashmil, R.; Goshevski, F.; Smith, J. N.; Taylor, D.; Pieper, A. A.; Markowitz, S. D.; Desai, A. B.
10.1101/2025.04.11.648417 — immunology — Posted on 2025-04-17
2352 Engineered protein circuits for cancer therapy
Lu, A. C.; Moeller, L.; Moore, S.; Xia, S.; Ho, K.; Zhang, E.; Budde, M. W.; Larson, H.; Ahmed Diaz, A.; Gu, B.; Linton, J. M.; Klock, L.; Flynn, M. J.; Gao, X. J.; Siegwart, D. J.; Zhu, H.; Elowitz, M. B.
10.1101/2025.04.16.647665 — synthetic biology — Posted on 2025-04-17
2356 Distinct tumor-immune ecologies in NSCLC patients predict progression and define a clinical biomarker of therapy response
Prabhakaran, S.; Gatenbee, C.; Robertson-Tessi, M.; Gray, J.; Antonia, S.; Beg, A. A.; Gatenby, R. A.; Anderson, A. R. A.
10.1101/2022.10.22.513219 — cancer biology — Posted on 2025-04-17
2357 Clinico-genomic features predict distinct metastatic phenotypes in cutaneous melanoma
Aprati, T. J.; Day, C.-P.; Lee, D.; Pan, A.; Jee, J.; Tarantino, G.; Manos, M. P.; Faulkner, H.; Holovatska, M. M.; Khaddour, K.; Feng, C. H.; Burke, K. P.; Glettig, M.; Weaver Ohler, Z.; El Meskini, R.; Boland, G. M.; Hodi, F. S.; Haq, R.; Shoushtari, A. N.; Schultz, N.; Ishizuka, J.; Gusev, A.; Griffin, M.; Kehl, K. L.; Liu, D.
10.1101/2025.01.24.633441 — cancer biology — Posted on 2025-04-17
2360 GESIAP3.0: Sensor-based Image Analysis Program for Transmission Visualization In Vivo
Zhu, R. E.; Diao, X.; Liu, X.; Ru, Q.; Wu, Z.; Zhang, Z.; Looger, L.; Zhu, J.
10.1101/2024.10.28.620522 — bioengineering — Posted on 2025-04-17
2361 Smoothened inhibition of PKA at cilia transduces Hedgehog signals
Nguyen, T. D.; Konjikusic, M. J.; Del Castillo, L. M.; Reiter, J. F.
10.1101/2025.04.01.646243 — biochemistry — Posted on 2025-04-17
2364 Decoding of T cell immunodominance patterns by an integrated mechanistic approach
Alvaro-Benito, M.; Abualrous, E. T.; Lingel, H.; Meltendorf, S.; Holzapfel, J.; de Diego Valera, P.; Sticht, J.; Kuropka, B.; Clementi, C.; Kuppler, F.; Brunner-Weinzierl, M. C.; Freund, C.
10.1101/2024.01.10.574975 — immunology — Posted on 2025-04-17
2365 Large-scale single-cell profiling of stem cells uncovers redundant regulators of shoot development and yield trait variation
Xu, X.; Passalacqua, M.; Rice, B.; Demesa-Arevalo, E.; Kojima, M.; Takebayashi, Y.; Harris, B.; Sakakibara, H.; Gallavotti, A.; Gillis, J.; Jackson, D.
10.1101/2024.03.04.583414 — plant biology — Posted on 2025-04-17
2367 Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics
Galvao, I. C.; Lemoine, M.; Kandratavicius, L.; Yasuda, C. L.; Alvim, M. K. M.; Ghizoni, E.; Blümcke, I.; Cendes, F.; Rogerio, F.; Lopes-Cendes, I.; Veiga, D. T.
10.1101/2024.12.12.628140 — neuroscience — Posted on 2025-04-17
2368 Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing
Park, J.; Sipe, G. O.; Tang, X.; Ojha, P.; Fernandes, G.; Leow, Y. N.; Zhang, C.; Osako, Y.; Natesan, A.; Drummond, G. T.; Jaenisch, R.; Sur, M.
10.1101/2024.11.06.622321 — neuroscience — Posted on 2025-04-17
2369 Mechanistic modeling of cell viability assays with in silico lineage tracing
Mutsuddy, A.; Huggins, J. R.; Amrit, A.; Harley-Gasaway, A. M.; Erdem, C.; Calhoun, J. C.; Birtwistle, M. R.
10.1101/2024.08.23.609433 — systems biology — Posted on 2025-04-17
2371 Universal protocol to separate and compare Extracellular Vesicles from human plasma and skeletal muscle biopsy
Mangolini, V.; Radeghieri, A.; Piva, S.; Cattaneo, S.; Brucale, M.; Valle, F.; Balestri, A.; Montis, C.; Latronico, N.; Bergese, P.; Paolini, L.
10.1101/2024.02.19.580950 — cell biology — Posted on 2025-04-17
2372 ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis
Fuller, D. M.; Wu, Y.; Schueder, F.; Rasool, B.; Nag, S.; Korfhage, J. L.; Garcia-Milian, R.; Melnyk, K. D.; Bewersdorf, J.; De Camilli, P.; Melia, T.
10.1101/2025.03.24.645038 — cell biology — Posted on 2025-04-17
2373 Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming
Reed, X.; Weller, C. A.; Saez-Atienzar, S.; Beilina, A.; Solaiman, S.; Portley, M.; Kaileh, M.; Roy, R.; Ding, J.; Moore, A. Z.; Whitaker, D. T.; Traynor, B. J.; Gibbs, J. R.; Scholz, S. W.; Cookson, M. R.
10.1101/2024.12.13.627515 — molecular biology — Posted on 2025-04-17
2374 Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1 dependent manner and reveal proviral roles of UPF1.
Prochasson, L.; Mghezzi-Habellah, M.; Roisin, A.; Palma, M.; Robin, J.-P.; de Bossoreille, S.; Cluet, D.; Mouehli, M.; Decimo, D.; Desrames, A.; Chaze, T.; Matondo, M.; Dutartre, H.; Thoulouze, M.-I.; Lejeune, F.; Jalinot, P.; Rety, S.; Mocquet, V.
10.1101/2023.06.20.545693 — molecular biology — Posted on 2025-04-17
2377 ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis
Gomez Deza, J.; Nebiyou, M.; El Touny, L. H.; Alkaslasi, M. R.; Zuo, Z.; Wlaschin, J. J.; Nadal-Nicolas, F. M.; Slavutsky, A. L.; Lloyd, E. Y.; Hayashi, P. M.; Ashby, N.; Sohn, M.; Li, W.; Cheng, K.; Rocha, P.; Le Pichon, C. E.
10.1101/2023.09.27.559856 — neuroscience — Posted on 2025-04-17
2378 Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat
Wang, X.; Zhao, P.; Shi, X.; Guo, X.; Liu, Y.; Hou, W.; Cheng, M.; Liu, X.; Lai, X.; Simmonds, J.; Harwood, W.; Wang, J.; Liu, Z.; Huang, L.; Han, D.; Ji, W.; Uauy, C.; Xiao, J.; Kang, Z.; Xu, S.
10.1101/2022.06.02.494553 — plant biology — Posted on 2025-04-17
2379 Expanding the Orchidaceae Virome Through Analysis of Public-Domain Sequencing Data
Perez, A.; Sanchez-Yali, J.; Higuita, M.; Ortiz-Reyes, A.; Gutierrez, P. A.
10.1101/2025.04.09.647952 — bioinformatics — Posted on 2025-04-17
2381 RNA condensates as platforms for prebiotic chemistry
Hauf, S.; Nakamura, R.; Cellini, B.; Yokobayashi, Y.; Dindo, M.
10.1101/2025.04.15.648868 — biochemistry — Posted on 2025-04-17
2386 Modeling neuron-astrocyte interactions in neural networks using distributed simulation
Jiang, H.-J.; Acimovic, J.; Manninen, T.; Ahokainen, I.; Stapmanns, J.; Lehtimäki, M.; Diesmann, M.; van Albada, S. J.; Plesser, H. E.; Linne, M.-L.
10.1101/2024.11.11.622953 — neuroscience — Posted on 2025-04-17
2387 Gut Microbe-Derived N-Acyl Serinol Lipids Shape Host Postprandial Metabolic Homeostasis
Dutta, S.; Mahen, K. K.; Massey, W. J.; Varadharajan, V.; Burrows, A.; Horak, A. J.; Mrdjen, M.; Mouannes, N.; Orabi, D.; Osborn, L.; Grubb, T.; Hohe, R.; Banerjee, R.; Uppin, V.; Laungani, D.; Hamilton, G.; Ye, X.; Sangwan, N.; Dwidar, M.; Hajjar, A.; Willard, B.; Martin, M.; Guetschow, E.; Westcott, P.; Wang, Z.; Hazen, S. L.; Brown, J. M.
10.1101/2025.04.11.648385 — physiology — Posted on 2025-04-17
2389 panomiX: Investigating Mechanisms Of Trait Emergence Through Multi-Omics Data Integration
Sahu, A.; Psaroudakis, D.; Rolletschek, H.; Neumann, K.; Borisjuk, L.; Himmelbach, A.; Pinninti, K.; Töpfer, N.; Szymanski, J. J.
10.1101/2025.04.11.648356 — bioinformatics — Posted on 2025-04-17
2391 Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus
Thomas, W. R.; Lama, T. M.; Moreno-Santillan, D.; Farre, M.; Baldoni, C.; Abueg, L.; Balacco, J.; Fedrigo, O.; Formenti, G.; Jain, N.; Mountcastle, J.; Tilley, T.; Tracey, A.; Ray, D. A.; Dechmann, D. K. N.; von Elverfeldt, D.; Nieland, J.; Corthals, A. P.; Jarvis, E.; Davalos, L. M.
10.1101/2025.04.11.648246 — evolutionary biology — Posted on 2025-04-17
2393 Spatially organized cellular communities shape functional tissue architecture in the pancreas
Torres-Cano, A.; Darrigrand, J.-F.; Herrera-Oropeza, G.; Goss, G.; Willnow, D.; Salowka, A.; Chitnis, D.; Rouault, M.; Vigilante, A.; Spagnoli, F. M.
10.1101/2025.04.16.649169 — developmental biology — Posted on 2025-04-17
2396 Neutrophils matter: New clinical insights on their role in the progression of metastatic breast cancer
Correia, B. F.; Grosa, D.; Salvador, R.; Brites, I.; Martins, T.; Vitorino, M.; Sousa, C. X.; Cristovao-Ferreira, S.; Braga, S.; Jacinto, A.; Cabral, M. G.
10.1101/2025.04.11.648384 — immunology — Posted on 2025-04-17
2398 Weakened prefrontal activation dynamics associated with slowed information processing speed in multiple sclerosis
Burta, O.; Akbarian, F.; Rossi, C.; Vidaurre, D.; d'Hooghe, M. B.; D'Haeseleer, M.; Nagels, G.; Van Schependom, J.
10.1101/2025.04.08.647709 — neuroscience — Posted on 2025-04-17
2400 Alzheimer's disease and its co-pathologies: implications for hippocampal degeneration, cognitive decline, and the role of APOE ϵ4
Gawor, K.; Verrept, S.; Arekatla, G.; Wouters, D.; Ronisz, A.; Hecht, M.; Laureyssen, C.; Ver Donck, H.; Lahaije, B.; Ospitalieri, S.; Vandenbulcke, M.; Otto, M.; von Arnim, C. A. F.; Ghebremedhin, E.; Hanseeuw, B.; Vandenberghe, R.; Blaschko, M.; Sifrim, A.; Sleegers, K.; Thal, D. R.; Tome, S. O.
10.1101/2025.04.11.648343 — neuroscience — Posted on 2025-04-17
2402 A structural basis for chaperone repression of stress signalling from the endoplasmic reticulum
Neidhardt, L.; Tung, J.; Kuchersky, M.; Milczarek, J.; Kargas, V.; Stott, K.; Rosenzweig, R.; Ron, D.; Yan, Y.
10.1101/2025.04.14.648677 — biochemistry — Posted on 2025-04-17
2403 Identification of Multi-landscape and Cell Interactions in the Tumor Microenvironment through High-Coverage Single-Cell Sequencing
Zhong, W.; Wang, L.; Zhang, C.; Guo, T.; zhao, l.; Wu, D.; Xie, F.; Wang, X.; Li, X.; Wang, F.; Li, M.; Gu, W.; Lin, T.; Chen, X.
10.1101/2024.06.18.599463 — genomics — Posted on 2025-04-17
2406 Dissociable dynamic effects of expectation during statistical learning.
McDermott, H. H.; De Martino, F.; Schwiedrzik, C. M.; Auksztulewicz, R.
10.1101/2024.09.05.611380 — neuroscience — Posted on 2025-04-17
2408 Intestinal Tissue Mechanics Regulate Angiogenesis and Stem Cell Proliferation via Vascular Piezo
Phillips, J. A.; Perochon, J.; Johnson, C. T.; Walker, M.; Nixon, C.; Hughes, M.; Barros Carvalho, A.; Yu, Y.; Mitchell, L.; Blyth, K.; Vassalli, M.; Cordero, J. B.
10.1101/2025.04.16.649133 — developmental biology — Posted on 2025-04-17
2410 Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy
Gupta, M.; Choi, H.; Kemp, S.; Furth, E. E.; Pickup, S.; Clendenin, C.; Orlen, M.; Rosen, M.; Liu, F.; Cao, Q.; Stanger, B.; Zhou, R.
10.1101/2024.11.22.624844 — cancer biology — Posted on 2025-04-17
2411 AF2χ: Predicting protein side-chain rotamer distributions with AlphaFold2
Cagiada, M.; Thomasen, F. E.; Ovchinnikov, S.; Deane, C.; Lindorff-Larsen, K.
10.1101/2025.04.16.649219 — biophysics — Posted on 2025-04-17
2415 Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein
Shinkai, Y.; Ding, Y.; Matsui, T.; Devitt, G.; Akiyama, M.; Shen, T.-L.; Nishida, M.; Ida, T.; Akaike, T.; Mahajan, S.; Fukuto, J. M.; Shigeta, Y.; Kumagai, Y.
10.1101/2023.10.19.563042 — biochemistry — Posted on 2025-04-17
2419 Parvovirus infection affects host cell nucleolar organization and ribosome biogenesis
Huttunen, M.; Hakanen, S.; Aho, V.; Leclerc, S.; Soenmez, A.; Kapishnikov, S.; Zannotti, A.; Ruokolainen, V.; Salokas, K.; Varjosalo, M.; Latonen, L.; Parrish, C. R.; Fahy, K.; Mattola, S.; Lafontaine, D. L.; Vihinen-Ranta, M.
10.1101/2022.06.07.495090 — cell biology — Posted on 2025-04-17
2420 Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients
Quan, C.; Wang, L.; Gao, J.; Li, Y.; Xu, X.; Li, H.; Gao, Z.; Ruan, W.; Liu, H.; Li, Q.; Xing, W.; Zhao, L.; Carr, M. J.; Shi, W.; Hou, H.
10.1101/2025.04.11.648365 — immunology — Posted on 2025-04-17
2421 Hippocampus facilitates reinforcement learning under partial observability
Pedamonti, D.; Mohinta, S.; Dimitrov, M.; Malagon-Vina, H.; Ciocchi, S.; Costa, R. P.
10.1101/2023.11.09.565503 — neuroscience — Posted on 2025-04-17
2422 TS2CG as a membrane builder
Schuhmann, F.; Stevens, J. A.; Rahmani, N.; Lindahl, I.; Brown, C. M.; Brasnett, C.; Anastasiou, D.; Bravo Vidal, A.; Geiger, B. J.; Marrink, S.-J.; Pezeshkian, W.
10.1101/2025.04.16.649160 — biophysics — Posted on 2025-04-17
2424 Structural basis of apoptosis induction by the mitochondrial voltage dependent anion channel
Daniilidis, M.; Guensel, U.; Broutzakis, G.; Janowski, R.; Leitl, K.; Fredriksson, K.; Niessing, D.; Gatsogiannis, C.; Hagn, F. X.
10.1101/2025.04.15.648943 — biophysics — Posted on 2025-04-17
2425 Scaling Large Language Models for Next-Generation Single-Cell Analysis
Rizvi, S. A.; Levine, D.; Patel, A.; Zhang, S.; Wang, E.; He, S.; Zhang, D.; Tang, C.; Lyu, Z.; Darji, R.; Li, M.; Sun, E.; Jeong, D.; Zhao, L.; Kwan, J.; Braun, D.; Hafler, B.; Ishizuka, J.; Dhodapkar, R.; Chung, H.; Azizi, S.; Perozzi, B.; van Dijk, D.
10.1101/2025.04.14.648850 — bioinformatics — Posted on 2025-04-17
2426 Genomic studies in Linum shed light on the evolution of the distyly supergene and the molecular basis of convergent floral evolution
Zervakis, P.-I.; Postel, Z.; Losvik, A.; Fracassetti, M.; Soler, L.; Proux-Wera, E.; Bunikis, I.; Churcher, A.; Slotte, T.
10.1101/2025.04.11.648331 — evolutionary biology — Posted on 2025-04-17
2428 Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques
de Weerd, L.; Hummel, S.; Mueller, S. A.; Paris, I.; Sandmann, T.; Eichholtz, M.; Gröger, R.; Englert, A.; Wagner, S.; Ha, C.; Davis, S. S.; Warkins, V.; Xia, D.; Nuscher, B.; Berghofer, A.; Reich, M.; Feiten, A. F.; Schlepckow, K.; Willem, M.; Lichtenthaler, S. F.; Lewcock, J. W.; Monroe, K. M.; Brendel, M.; Haass, C.
10.1101/2025.04.10.645950 — neuroscience — Posted on 2025-04-17
2429 Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings
Meszena, D.; Fadel, W.; Toth, R.; Paulk, A. C.; Cash, S. S.; Williams, Z.; Kiss, T.; Stippinger, M.; Wittner, L.; Fiath, R.; Somogyvari, Z.
10.1101/2025.04.11.648355 — neuroscience — Posted on 2025-04-17
2431 Small things matter: Lack of extra-islet beta cells in Type 1 diabetes
Murrall, K.; Luckett, T.; Lekka, C.; Flaxman, C. S.; Wyatt, R.; Akhbari, P.; Kusmartseva, I.; Hunter, S. L.; Leete, P.; Burn, I.; Osokina, E.; EXE-T1D Consortium, ; Shaw, J. A. M.; Morgan, N. G.; Richardson, S. J.
10.1101/2025.04.11.648319 — pathology — Posted on 2025-04-17
2433 CellFlow enables generative single-cell phenotype modeling with flow matching
Klein, D.; Fleck, J. S.; Bobrovskiy, D.; Zimmermann, L.; Becker, S.; Palma, A.; Dony, L.; Tejada-Lapuerta, A.; Huguet, G.; Lin, H.-C.; Azbukina, N.; Sanchis-Calleja, F.; Uscidda, T.; Szalata, A.; Gander, M.; Regev, A.; Treutlein, B.; Camp, J. G.; Theis, F. J.
10.1101/2025.04.11.648220 — bioinformatics — Posted on 2025-04-17
2436 Chemosensitive brainstem and diencephalic components in breath-hold fMRI
Cauzzo, S.; Callara, A. L.; Morelli, M. S.; Hartwig, V.; Sozzi, S.; Frijia, F.; Esposito, F.; Bianciardi, M.; Montanaro, D.; Passino, C.; Emdin, M.; Giannoni, A.; Vanello, N.
10.1101/2025.04.11.648311 — bioengineering — Posted on 2025-04-17
2439 Genome-wide differentiation and SNP-based identification of northeastern Atlantic Sebastes species
Jansson, E.; Besnier, F.; Christiansen, H.; Saha, A.; Tranang, C. A.; Bruvold, I. M.; Mateos Rivera, A.; Johansen, T.
10.1101/2025.04.11.648347 — genetics — Posted on 2025-04-17
2440 Predicting kinship dynamics during pre- and post reproductive life stages
He, P.; Weiss, M. N.; Ellis, S.; Franks, D. W.; Cant, M. A.; Croft, D. P.; Johnstone, R. A.
10.1101/2025.04.11.648073 — evolutionary biology — Posted on 2025-04-17
2444 A community-consensus reconstruction of Chinese Hamster metabolism enables structural systems biology analyses to decipher metabolic rewiring in lactate-free CHO cells
Di Giusto, P.; Choi, D.-H.; Antonakoudis, A.; Duraikannan, V. G.; Craveur, P.; Cowie, N. L.; Ganapathy, T.; Ramesh, K.; Benavidez-Lopez, S.; Orellana, C. A.; Jimenez, N. E.; Dworkin, L. A.; Morrissey, J.; Marin de Mas, I.; Strain, B.; Valdez-Cruz, N. A.; Trujillo-Roldan, M. A.; Marzluf, J.; Martinez, V. S.; Zehetner, L.; Altamirano, C.; Vega-Letter, A. M.; Priem, B.; Cao, H. C.; Hold, M.; Ma, J.; Hong, Y.; Gopalakrishnan, S.; Enuh, B. M.; Tarzi, C.; Pang, K. T.; Angione, C.; Zanghellini, J.; Kontoravdi, C.; Hefzi, H.; Betenbaugh, M. J.; Nielsen, L. K.; Lakshmanan, M.; Lee, D.-Y.; Richelle, A.;
10.1101/2025.04.10.647063 — systems biology — Posted on 2025-04-17
2445 A longitudinal evaluation of localised chronic Pseudomonas aeruginosa infection in cystic fibrosis rat models
Reyne, N.; Boog, B.; Cmielewski, P.; McCarron, A.; Smith, R.; Rout-Pitt, N.; Eikelis, N.; Nilsen, K.; Finnie, J.; Louise, J.; Parsons, D.; Donnelley, M.
10.1101/2025.04.11.647899 — pathology — Posted on 2025-04-17
2446 NSUN2 drives intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling
Bastem Akan, A.; Billard, C. V.; Chen, S.-Y.; Huang, P.-H.; Cammareri, P.; Hall, A. E.; Preyzner, P.; Din, F. V. N.; Myant, K. B.
10.1101/2025.04.11.648351 — cancer biology — Posted on 2025-04-17
2447 Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities
Kuo, H.-H.; Bhinder, B.; Gokozan, H. N.; Gorski, K.; Chandra, P.; Manohar, J.; Guevara, D.; Otilano, J.; Moyer, J.; Tranquille, M.; Ackermann, S.; Capuano, J.; Cheung, C.; Caiazza, T. A.; Reuben, P. L.; Irizarry, A.; Tsomides, A. M.; Sigouros, M.; Wilkes, D.; King, A.; Kane, T.; Al Assaad, M.; Al Zoughbi, W.; Ohara, K.; Auh, J.; Waltman, P.; Madorsky Rowdo, F. P.; Podaza, E.; Gallegos, V.; Nguyen, J.; Shah, R.; Shah, M.; Ocean, A.; Scherr, D.; Altorki, N.; Frey, M.; Molina, A. M.; Newman, L.; Bea, V.; Chapman-Davis, E.; Goncalves, M. D.; Saxena, A.; Shukla, P. J.; Holcomb, K.; Simmons, R.; Tag
10.1101/2025.04.10.647635 — cancer biology — Posted on 2025-04-17
2452 An integrative taxonomic approach reveals unexplored diversity in Croatian planarians
Vila-Farre, M.; Brand, J. N.; Boothe, T.; Brockmeyer, M.; Ficze-Schmidt, F.; Grohme, M. A.; Weill, U.; Kluiver, K. H.; Gasiorowski, L.; Kauf, L.; Kanana, Y.; Bilandzija, H.; Riutort, M.; Rink, J. C.
10.1101/2025.04.10.648211 — zoology — Posted on 2025-04-16
2453 PMI estimation on aqueous humour: human translation from a metabolomic animal model.
Chighine, A.; Stocchero, M.; De-Giorgio, F.; Nioi, M.; d'Aloja, E.; Locci, E.
10.1101/2025.04.15.648907 — systems biology — Posted on 2025-04-17
2455 Detection of Aggressive Mesenchymal Glioblastoma by Mannose-Weighted CEST MRI
Ghaemi, B.; Lopez-Bertoni, H.; Kuddannaya, S.; Sall, S.; Laterra, J.; Liu, G.; Bulte, J.
10.1101/2025.04.15.648948 — cancer biology — Posted on 2025-04-17
2456 Targeting protein glycosylation and cholesterol metabolism in chemoresistant pancreatic cancer
Li, Y.; Tang, S.; Wang, H.; Zhu, H.; Guo, S.; Zhang, Y.; Lu, Y.; Sun, M.; He, J.; Li, Y.; Zhang, Y.; Shi, X.; Miao, Y.; Zhong, C.; Zhu, Y.; Ju, Y.; Liu, Y.; Wang, Y.; Chen, L.; Zhou, H.; Jin, G.; Gao, D.
10.1101/2025.04.13.648567 — cancer biology — Posted on 2025-04-17
2459 Phase Separation and a Hydrodynamic Instability Localize Proteins at Growing Microtubule Ends
Schaer, J.; Miesch, J.; Catapano, V.; Dumoulin, L.; Tran, J.; Velluz, M.-C.; Aumeier, C.; Kruse, K.
10.1101/2025.04.11.648094 — biophysics — Posted on 2025-04-17
2461 Nanobodies as therapies for loss-of-function misfolding diseases.
Mulas, A. G.; Dindo, M.; Pacheco, J. L.; Grotelli, S.; Cano, M.; Vankova, P.; Loginov, D.; Salido, E.; Man, P.; Conejero-Lara, F.; Cellini, B.; Pey, A. l.
10.1101/2025.04.12.648492 — biophysics — Posted on 2025-04-17
2463 Characterization of PROTACs by Ternary Complex Landscape Exploration using Monte Carlo simulations
Diaz-Rovira, A. M.; Perez-Lopez, C.; Martin-Perez, J.; Pallara, C.; Diaz, L.; Guallar, V.
10.1101/2025.04.11.648328 — biophysics — Posted on 2025-04-17
2465 Measuring the selective packaging of RNA molecules by viral coat proteins in cells
Rastandeh, A.; Makasarashvili, N.; Dhaliwal, H. K.; Subramanian, S.; Villarreal, D. A.; Baker, S.; Gamez, E. I.; Parent, K. N.; Garmann, R. F.
10.1101/2025.04.14.648219 — biophysics — Posted on 2025-04-17
2467 Gliomas organize as liquid crystals: three-dimensional nematic order, disclinations and quasi-long-range order
Argento, A. E.; Varela, M. L.; Singh, G.; Visnuk, D. P.; Jacobovitz, B.; Rutherford, M. E.; Edwards, M. B.; Chaboche, Q.; Orringer, D. A.; Heth, J. A.; Castro, M. G.; Beller, D. A.; Blanch-Mercader, C.; Lowenstein, P.
10.1101/2025.04.14.648711 — biophysics — Posted on 2025-04-17
2469 Glycoengineering of nematode antigens using insect cells: a promising approach for producing bioactive vaccine antigens of the barber's pole worm Haemonchus contortus
Adduci, I.; Sajovitz-Grohmann, F.; Wortha, L. N.; Dutkiewicz, Z.; Weidinger, H.; Rohrer, S. B.; Joachim, A.; Wittek, T.; Werling, D.; Wilson, I. B. H.; Lichtmannsperger, K.; Yan, S.
10.1101/2025.04.11.646772 — bioengineering — Posted on 2025-04-17
2471 Peruvian Population Genomics: Unraveling the Genetic Landscape and Admixture Dynamics of Urban Populations
Borda, V.; Caceres, O.; Sanchez, C.; Padilla, C.; Veliz-Otani, D.; Mendes, M.; Silva-Carvalho, C.; Alvin, I.; Maron, B. A.; Gouveia, M. H.; Peruvian Genome Project Consortium, ; Tarazona-Santos, E.; Guio, H.; O'Connor, T. D.
10.1101/2025.04.10.648256 — genetics — Posted on 2025-04-16
2472 A genomic perspective on the origins, evolution and adaptation of Galapagos iguanas
Lopez-Delgado, J.; Carr, I. M.; Paradiso, C.; Gratton, P.; Colosimo, G.; van den Burg, M. P.; Debrot, A. O.; Sevilla, C. R.; Mat-Isa, M. N.; Bayliss, R.; Gerber, G. P.; Raih, M. F.; O'Connell, M. J.; Gentile, G.; Goodman, S. J.
10.1101/2025.04.13.648612 — evolutionary biology — Posted on 2025-04-17
2475 Habitat use and diel activity of insectivorous bats across land-use types on an Afrotropical oceanic island
Palmeirim, A. F.; Araujo-Fernandes, A. C.; Castro-Fernandes, A. S.; Guedes, P.; Santos, Y. d.; Alves, J. C.; Mata, V. A.; Yoh, N.; Rocha, R.
10.1101/2025.04.10.648189 — ecology — Posted on 2025-04-16
2477 Boosting Cellular Longevity Through Intracellular ATP Modulation
Oz, N.; Su, H.; Patnaik, P.; Prosser, D.; Labunskyy, V.; Hameed, R.; Gladyshev, V. N.; Hao, N.; Kaya, A.
10.1101/2025.04.14.648769 — molecular biology — Posted on 2025-04-16
2478 Polymyxin B lethality requires energy-dependent outer membrane disruption
Borrelli, C.; Douglas, E. J. A.; Riley, S. M. A.; Lemonidi, A. E.; Larrouy-Maumus, G. B.; Lu, W.-J.; Bonev, B. B.; Edwards, A. M.; Hoogenboom, B. W.
10.1101/2025.04.16.649083 — microbiology — Posted on 2025-04-16
2482 Characterization and evolutionary history of novel SARS-CoV-2-related viruses in bats from Cambodia
Ou, T. P.; Guillebaud, J.; Baidaliuk, A.; Tum, S.; Chheang, D.; Delaune, D.; Prot, M.; Rahal Guaragna Machado, R.; Pum, L.; Hul, V.; Hoem, T.; Ly, S.; Auerswald, H.; Smith, G. J.; Dussart, P.; Karlsson, E. A.; Chevalier, V.; Cappelle, J.; Duong, V.; Simon-Loriere, E.
10.1101/2025.04.15.648942 — microbiology — Posted on 2025-04-16
2483 Plant miRNAs and amino acids interact to shape soil bacterial communities.
Dozois, J. A.; Duchesne, M.-A.; Hallaf, K.; Tremblay, J.; Yergeau, E.
10.1101/2025.04.16.649127 — microbiology — Posted on 2025-04-16
2484 The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children
Nicholson, M.; Ma, S.; Stricland, B. A.; Cecala, M.; Zhang, L.; Reasoner, S.; Guiberson, E.; Munneke, M.; Shilts, M. H.; Skaar, E. P.; Das, S. R.
10.1101/2025.04.16.648821 — microbiology — Posted on 2025-04-16
2487 Phylogenetic position and mitochondrial genome evolution of 'orphan' eukaryotic lineages
Zlatogursky, V.; Boscaro, V.; Lax, G.; Wanntorp, M.; Pohl, N.; Burki, F.; Keeling, P. J.
10.1101/2025.04.16.649146 — microbiology — Posted on 2025-04-16
2489 Rhesus macaques model human Mayaro virus disease and transmit to Aedes aegypti mosquitoes
Moore, A. J.; Van Rompay, K. K. A.; Louie, W.; Watanabe, J. K.; An, S.; Leung, R.; Usachenko, J. L.; Chu, P. N.; Olstad, K. J.; McCoy, C. S.; Campos, R. K.; Weaver, S. C.; Rossi, S. L.; Coffey, L. L.
10.1101/2025.04.16.649064 — microbiology — Posted on 2025-04-16
2494 Discovery of a new evolutionarily conserved short linear F-actin binding motif
Paraschiakos, T.; Yuan, B.; Sopelniak, K.; Bucher, M.; Simon, L.; Zonjic, K.; Eggers, D.; Selle, F.; Li, J.; Linder, S.; Marlovits, T. C.; Windhorst, S.
10.1101/2025.04.16.649135 — biochemistry — Posted on 2025-04-16
2496 Genomic and Bioinformatic Insights into Enterococcus faecalis from Retail Meats in Nigeria
Osunla, C. A.; Akinbobola, A.; Elshafea, A.; Asare Yeboah, E. E.; Bakare, O. S.; Fayanju, A.; Fatoba, D.; Boamah, B.; Amoako, D. G.
10.1101/2025.04.15.648955 — genomics — Posted on 2025-04-16
2497 Quantifying virus load and characterising virus diversity in wildlife samples with target enrichment sequencing
Bergner, L.; Catalano, S.; Nichols, J.; Filipe, A. D. S.; Cao, X.; Mair, D.; Nankasi, A.; Arinaitwe, M.; Mubangizi, A.; Pybus, O.; Standley, C.; Faust, C. L.; Raghwani, J.
10.1101/2025.04.16.648874 — genomics — Posted on 2025-04-16
2498 Retroelement expansions underlie genome evolution in stingless bees
Araujo, N. d. S.; Azevedo, P.; Ferrari, R. R.; dos Santos, L. B.; Rodriguez, F.; Nocelli, R. C. F.; Hudson, M.; Batista, T. M.; Hartfelder, K.; Aron, S.
10.1101/2025.04.12.648530 — genomics — Posted on 2025-04-16
2500 Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Shrestha, S.; Maitland, M. E.; Jing, L.; Duan, S.; Nie, D. Y.; St-Germain, J.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Raught, B.
10.1101/2025.04.14.648778 — molecular biology — Posted on 2025-04-16
2502 Disruption of putrescine export in experimentally evolved Ralstonia pseudosolanacearum enhances symbiosis with Mimosa pudica
Cazale, A.-C.; Navarro, M.; Doin de Moura, G. G.; Hoarau, D.; Bellvert, F.; Valiere, S.; Baroukh, C.; Remigi, P.; GUIDOT, A.; CAPELA, D.
10.1101/2025.04.16.649159 — microbiology — Posted on 2025-04-16
2504 Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis Lineage 2
Koleske, B.; Schill, C.; Rajagopalan, S.; Shee, S.; Martinez-Martinez, Y. B.; Gupta, M.; Shen, J.; Jacobs, W. R.; Bishai, W. R.
10.1101/2025.04.16.649112 — microbiology — Posted on 2025-04-16
2507 Use of ANCHOR viruses to validate radiative, physical and chemical decontamination systems in operational conditions.
Gallardo, F.; Poirier, V.; Quentin-Froignant, C.; Figueroa, T.; Volmer, R.; Mousnier, M.; Authier, O.; Lainisalo, D.; Lainisalo, P.; Ingelius, T.; Grandadam, M.; Marcheteau, E.
10.1101/2025.04.15.648913 — microbiology — Posted on 2025-04-16
2509 A Novel Technique for Fluorescence Lifetime Tomography
Nizam, N. I.; Pandey, V.; Erbas, I.; Bracher, N. L.; Smith, J. T.; Intes, X.
10.1101/2024.09.19.613888 — bioengineering — Posted on 2025-04-16
2510 A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial Optimization
Ashraf, F. B.; Paco, K.; Zhang, Z.; Ojeda, C. J. D.; Mendivil, M. P.; Lay, J. A.; Yang, T. Y.; Silva, F. L. B. d.; Sazinsky, M. H.; Ray, A.; Lonardi, S.
10.1101/2024.12.19.629473 — molecular biology — Posted on 2025-04-16
2511 Clostridioides difficile in Equidae necropsied in north-western France, in 2019-2021: common carriage of toxigenic strains and virulence of emerging ribotype 017
Petry, S.; Tapprest, J.; Maillard, K.; Barbut, F.; DUQUESNE, F.; Kozak, S.; FOUCHER, N.; BERNEZ-ROMAND, M.; Bridoux, L.; Poquet, I.
10.1101/2024.09.30.615820 — microbiology — Posted on 2025-04-16
2512 ENTPD3-specific CAR Regulatory T cells for Local Immune Control in T1D
Pieper, T.; Riet, T.; Saetzler, V.; McGovern, J.; Delsing, L.; Atkinson, M.; Lodie, T.; Jermutus, L.; Noyan, F.; Hust, M.; Kusmartseva, I.; Hagedorn, M.; Lieber, M.; Henschel, P.; Glaser, V.; Geffers, R.; Polansky-Biskup, J.; Yang, M.; Eiz-Vesper, B.; Bonifacius, A.; Martinez Llordella, M.; Bergerhoff, K.; Henry, L.; Penston, D.; Gavriil, A.; Grothier, T.; Nikolopoulou, E.; Demertzis, N.; Koullourou, V.; Cox, P.; Zarrouki, B.; Sini, M.; Pfeiff, J.; Matthiesen, I.; Hardtke-Wolenski, M.; Jaeckel, E.
10.1101/2024.11.12.622951 — immunology — Posted on 2025-04-16
2513 The development of aperiodic neural activity in the human brain
Cross, Z. R.; Gray, S. M.; Dede, A. J. O.; Rivera, Y. M.; Yin, Q.; Vahidi, P.; Rau, E. M. B.; Cyr, C.; Holubecki, A. M.; Asano, E.; Lin, J. J.; McManus, O. K.; Sattar, S.; Saez, I.; Girgis, F.; King-Stephens, D.; Weber, P. B.; Laxer, K. D.; Schuele, S. U.; Rosenow, J. M.; Wu, J. Y.; Kam, S. K.; Raskin, J. S.; Chang, E. F.; Shaikhouni, A.; Brunner, P.; Roland, J. L.; Braga, R. M.; Knight, R. T.; Ofen, N.; Johnson, E. L.
10.1101/2024.11.08.622714 — neuroscience — Posted on 2025-04-16
2514 Immunocompetent murine models recapitulate the heterogeneous tumor immune microenvironment of human liposarcoma
Shafer, A. M.; Kenna, E.; Golden, L.-A. F.; Elhossiny, A. M.; Perry, K. D.; Wilkowski, J.; Yan, W.; Kaczkofsky, B.; McGue, J.; Bresler, S. C.; Courtney, A. H.; Dalman, J. M.; Galban, C. J.; Jiang, W.; Espinoza, C. E.; Chugh, R.; Iyer, M. K.; Frankel, T. L.; Pasca di Magliano, M.; Dlugosz, A. A.; Angeles, C. V.
10.1101/2025.01.31.634916 — cancer biology — Posted on 2025-04-16
2515 Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model
Browning, A. P.; Crossley, R. M.; Villa, C.; Maini, P. K.; Jenner, A. L.; Cassidy, T.; Hamis, S.
10.1101/2024.08.19.608540 — cancer biology — Posted on 2025-04-16
2517 PISA: a versatile interpretation tool for visualizing cis-regulatory rules in genomic data
McAnany, C. E.; Weilert, M.; Kamulegeya, F.; Mehta, G.; Gardner, J. M.; Kundaje, A.; Zeitlinger, J.
10.1101/2025.04.07.647613 — genomics — Posted on 2025-04-16
2521 PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses
Parthasarathy, S.; Saenjamsai, P.; Hao, H.; Ferkul, A.; Pfannenstiel, J. J.; Bejan, D. S.; Chen, Y.; Suder, E. L.; Schwarting, N.; Aikawa, M.; Muhlberger, E.; Hume, A. J.; Orozco, R. C.; Sullivan, C. S.; Cohen, M. S.; Davido, D.; Fehr, A.
10.1101/2024.04.26.591186 — microbiology — Posted on 2025-04-16
2522 Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections
Ono, M.; Yamaguchi, M.; Motooka, D.; Hirose, Y.; Higashi, K.; Sumitomo, T.; Miyoshi-Akiyama, T.; Okuno, R.; Yamaguchi, T.; Kawahara, R.; Otsuka, H.; Nakanishi, N.; Kazawa, Y.; Nakagawa, C.; Yamaguchi, R.; Sakai, H.; Matsumoto, Y.; Ikebe, T.; Kawabata, S.
10.1101/2024.07.02.601674 — microbiology — Posted on 2025-04-16
2524 Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum
Treuting, R. L.; Boroujeni, K. B.; Gerrity, C. G.; Neumann, A.; Tiesinga, P.; Womelsdorf, T.
10.1101/2024.06.12.598723 — neuroscience — Posted on 2025-04-16
2526 Integrative spatial transcriptomic analysis pinpoints the role of the ferroxidase, TaMCO3, in wheat root tip iron mobilization
Joon, R.; Singh, G.; Tyagi, D.; Meena, V.; Shukla, V.; Agrwal, K.; Saini, S.; Jot, M.; Banoo, H.; Satbhai, S.; Singh, J.; Long, T.; Ramireddy, E.; PANDEY, A. K.
10.1101/2025.01.22.634289 — plant biology — Posted on 2025-04-16
2527 RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.
Flores Gonzalez, R. E.; Goncalves, C.; Wirasinghe, N.; Gaudeault, V.; Noda Ferro, J. M.; Coutant, K.; Mitchell, A.; Guettler, E.; Gonzalez Moreno, D. R.; Preston, S.; Cai, F.; Gagnon, N.; Jean, S.; Landreville, S.; Miller, W. H.; Del Rincon, S. V.
10.1101/2025.02.23.639782 — cancer biology — Posted on 2025-04-16
2528 NetSyn: genomic context exploration of protein families
Stam, M.; Langlois, j.; Chevalier, C.; Mainguy, J.; Reboul, G.; Bastard, K.; Medigue, C.; Vallenet, D.
10.1101/2023.02.15.528638 — bioinformatics — Posted on 2025-04-16
2530 Impacts on the microbial fungal communities across water, sediment, and amphibian hosts across an urbanization gradient waterway in Worcester, Massachusetts
Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.
10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-16
2531 A cellular basis for the mammalian nocturnal-diurnal switch
Beale, A. D.; Christmas, M. J.; Rzechorzek, N. M.; Mihut, A.; Zeng, A.; Ellis, C.; James, N. R.; Smyllie, N. J.; Pilorz, V.; Richardson, R.; Bertelsen, M. F.; Fazal, S. V.; Voysey, Z.; Moreau, K.; Pelletier, J.; Crosby, P.; Peak-Chew, S. Y.; Edgar, R. S.; Lancaster, M. A.; Hut, R. A.; O'Neill, J. S.
10.1101/2023.06.22.546020 — cell biology — Posted on 2025-04-16
2532 Submitochondrial Protein Translocation in Thermogenic Regulation
Haczeyni, F.; Jordan, J. M.; Stein, B. D.; Steensels, S.; Li, L.; Dartigue, V.; Sarklioglu, S.; Qiao, J.; Zhou, X. K.; Dannenberg, A. J.; Iyengar, N.; Yu, H.; Cantley, L. C.; Ersoy, B. A.
10.1101/2023.05.04.539294 — molecular biology — Posted on 2025-04-16
2533 Humanized mouse models to support therapeutic development for SYNGAP1 and STXBP1 disorders
Felix, A. J.; Brown, B. L.; Marotta, N.; Gessner, M. J.; Wilson, T.; Randell, R.; Dawicki-McKenna, J.; Reinhardt, D.; Uchida, K.; Boland, M. J.; Davidson, B. L.; Prosser, B. L.
10.1101/2024.08.22.609238 — neuroscience — Posted on 2025-04-16
2534 Fiber Microstructure Quantile (FMQ) Regression: A Novel Statistical Approach for Analyzing White Matter Bundles from Periphery to Core
Lan, Z.; Chen, Y.; Rushmore, J.; Zekelman, L.; Makris, N.; Rathi, Y.; Golby, A. J.; Zhang, F.; O'Donnell, L. J.
10.1101/2024.10.19.619237 — neuroscience — Posted on 2025-04-16
2535 Somites are a source of nephron progenitors in zebrafish
Davidson, A. J.; Peng, Z.; Vanichapol, T.; Nguyen, P. D.; Chang, H.-H. G.; Kocha, K. M.; O'Brien, L.; Currie, P.; Huang, P.
10.1101/2025.04.15.649022 — developmental biology — Posted on 2025-04-16
2536 DNA Methylation in Sex Chromosomes and Genes under Selection Underpins the Emergence of Sexual Size Dimorphism
Wang, Q.; Hao, X.; Anastasiadi, D.; Liu, K.; Li, S.; Feng, B.; Wang, R.; Ritchie, M. G.; Liu, Y.; Wang, H.; Tang, L.; Piferrer, F.; Shao, C.
10.1101/2025.04.14.648707 — developmental biology — Posted on 2025-04-16
2540 Primary and secondary microplastics do not affect hatching of Japanese flounder eggs
Azmi, S. S.; SEONG, T.; KIM, H.-J.; NAKATANI, H.; KYOZUKA, Y.; ASAKURA, H.; SHIMIZU, K.; Yagi, M.
10.1101/2025.04.15.648670 — developmental biology — Posted on 2025-04-16
2542 Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity
Bunner, S.; Huang, K.; Shah, A.; Lang, N. D.; Chu, C.; Figueroa, S.; Eskndir, N.; Pho, M.; Manning, G.; Fritz-Laylin, L.; Velle, K. B.; Marcus, J.; Orth, J.; Stephens, A. D.
10.1101/2025.04.16.649171 — cell biology — Posted on 2025-04-16
2544 Intestinal Tissue Mechanics Regulate Angiogenesis and Stem Cell Proliferation via Vascular Piezo
Cordero, J. B.; Phillips, J. A.; Perochon, J.; Johnson, C. T.; Walker, M.; Nixon, C.; Hughes, M.; Barros Carvalho, A.; Yu, Y.; Mitchell, L.; Blyth, K.; Vassalli, M.
10.1101/2025.04.16.649133 — developmental biology — Posted on 2025-04-16
2545 FGF overactivation underlies reduced neurogenesis in cerebellar organoid models of neurodevelopmental ciliopathy
Brunetti, L.; Wiegering, A.; Anselme, I.; Pollara, L.; Catala, M.; Antoniewski, C.; Valente, E. M.; Schneider-Maunoury, S.; Vesque, C.
10.1101/2025.04.14.648790 — developmental biology — Posted on 2025-04-16
2547 Spatial activation of Kinesin-1 by Ensconsin shapes microtubule networks via ncMTOCs recruitment
Berisha, A.-M.; Pascal, A.; Guelle, M.; clement, B.; Chretien, D.; Bataille, L.; GIET, R.
10.1101/2025.04.15.648882 — developmental biology — Posted on 2025-04-16
2550 Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development
Jimenez, S.; Blot, F.; Meunier, A.; Schreiber, V.; Giethlen, C.; Ghimire, S.; Mahe, M.; Molina, N.; De Arcangelis, A.; Gradwohl, G.
10.1101/2025.04.11.648332 — developmental biology — Posted on 2025-04-16
2553 CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis
Lammlin, L.; Redding, S.; Knights, A. J.; Mohan, A.; Newton, M. D.; Bergman, R. F.; Smith, I. J.; Howser, S. C.; Gonzalez-Nolde, S.; Rzeczycki, P. M.; Adamczyk, N. S.; Miller, R. E.; Maerz, T.
10.1101/2025.04.10.647297 — physiology — Posted on 2025-04-16
2557 Item recognition is associated with gut microbiota composition in healthy humans
Oyarzun, J. P.; Kuntz, T. M.; Morgan, X. C.; Davachi, L.; Huttenhower, C.; LeDoux, J. E.; Phelps, E. A.
10.1101/2025.04.10.648258 — animal behavior and cognition — Posted on 2025-04-16
2559 Aberrant formation of long-range projections across different neurodevelopmental disorders converges on molecular and cellular nexuses
Furlanetto, F.; Segura, A.; Kravikass, M.; Dolai, P.; Frank, S.; Turan, S.; Luna, A.; Kaeseberg, S.; Schweiger, S.; Lie, C. D.; Zaburdaev, V.; Karow, M.; Falk, S.
10.1101/2025.04.15.648981 — developmental biology — Posted on 2025-04-16
2560 tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans
Galambos, N. S.; Crocker, O. J.; Schneider, B. K.; Allerton, K. S.; Gross, K. E.; Schneider, A. E.; Lynch, J.; Yukselen, O.; Kucukural, A.; Conine, C. C.
10.1101/2025.04.14.648817 — developmental biology — Posted on 2025-04-16
2561 FGF8 promotes lipid droplet accumulation via the FGFR1/p-p38 axis in chondrocytes
huang, m.; chen, h.; wei, j.; pi, c.; duan, m.; pu, x.; niu, z.; xu, s.; tu, s.; liu, s.; li, j.; zhang, l.; liu, y.; chen, h.; xu, c.; xie, j.
10.1101/2025.04.15.648880 — cell biology — Posted on 2025-04-16
2562 Single cell mapping of the metabolic landscape of skin fibrosis in systemic sclerosis
Devakumar, V.; Li, Y.-N.; Filla, T.; Rigau, A. R.; Gyorfi, A.-H.; Tuemerdem, B. S.; Neelagar, R.; Liang, M.; Bergmann, C.; Schett, G.; Distler, J. H. W.; Matei, A.-E.
10.1101/2025.04.14.648761 — cell biology — Posted on 2025-04-16
2564 High-performance proteomics at any chromatographic flow rate
tsiklauri, g.; Zheng, R.; Kabella, N.; Prokofeva, P.; Pynn, C.; Kuster, B.
10.1101/2025.04.10.648108 — systems biology — Posted on 2025-04-16
2566 THE FUNCTION AND EVOLUTION OF STEGOSAUR OSTEODERMS AND HYPOTHESIZED SEXUAL DIMORPHISM IN HESPEROSAURUS
Saitta, E. T.; Bonhomme, V.; Lukens, M.; Vidal, D.; Longrich, N. R.; Richmond, D. R.; Stockdale, M. T.
10.1101/2025.04.10.648273 — paleontology — Posted on 2025-04-16
2568 Benchmarking single cell transcriptome matching methods for incremental growth of reference atlases
Hu, J.; Peng, B.; Pankajam, A. V.; Xu, B.; Deshpande, V. A.; Bueckle, A. D.; Herr, B. W.; Borner, K.; Dupont, C. L.; Scheuermann, R. H.; Zhang, Y.
10.1101/2025.04.10.648034 — bioinformatics — Posted on 2025-04-16
2570 MRI-free Virtual Neuronavigation for TMS
Valter, Y.; Truong, D. q.; Kawasumi, Y.; Bikson, M.; Datta, A.
10.1101/2025.04.10.648190 — bioengineering — Posted on 2025-04-16
2572 Single-Cell eQTL Mapping Reveals Cell Type-Specific Genetic Regulation in Lung Cancer
Fu, Y.; Wang, Y.; Zhang, C.; Jin, C.; Cai, J.; Gong, L.; Jin, C.; Ji, C.; Mou, Y.; Zhang, C.; Wu, S.; Ge, X.; Dai, Y.; Miao, S.; Ma, H.; Ma, X.; Wang, M.; Bian, L.; Zhang, E.; Dai, J.; Hu, Z.; Jin, G.; Zhu, M.; Shen, H.; Ma, H.
10.1101/2025.04.10.646767 — genetics — Posted on 2025-04-16
2575 Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries
Pauli, J.; Garger, D.; Peymani, F.; Wettich, J.; Sachs, N.; Wirth, J.; Zhang, H.; Tabas, I.; Tall, A.; Li, M.; Reilly, M.; Branzan, D.; Prokisch, H.; Menden, M. P.; Maegdefessel, L.
10.1101/2025.04.16.649077 — cell biology — Posted on 2025-04-16
2577 Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy
Zheng, T.; Ramanathan, K.; Ormhoj, M.; Hansen, M. R.; Halldorsdottir, H. R.; Li, H.; Munk, K. K.; Rodriguez-Pardo, C.; Friis, R. U. W.; Islam, S. F.; Heegaard, P. M. H.; Qvortrup, K.; Abken, H.; Sun, Y.; Hardup, S. R.
10.1101/2025.04.10.648181 — immunology — Posted on 2025-04-16
2578 A Spray Dried Replicon Vaccine Platform for Pandemic Response
McClary, W. D.; Chen, J. Z.; Wang, H.; Lo, E.; Bakken, J.; McCollum, J.; Press, C.; Melief, E.; Brandt, D. S.; Martin, A. R.; Vehring, R.; Kasal, D. N.; Voigt, E. A.; Gerhardt, A.
10.1101/2025.04.10.648241 — immunology — Posted on 2025-04-16
2579 Submicron-Sampling of Living Cells by Macrophages
Fan, A. C.; Thota, R.; Serwas, N.; Marchuk, K.; Ruhland, M.; Edwards, A.; Krummel, M. F.
10.1101/2025.04.10.648051 — immunology — Posted on 2025-04-16
2581 Posterior parietal cortex activity during visually cued gait: a preliminary study
McDonnell, P.; Grimmitt, A. B.; Moreno-Jaramillo, J.; Hoogkamer, W.; Martini, D. N.
10.1101/2025.04.10.648269 — neuroscience — Posted on 2025-04-16
2582 Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma
He, L.; Chen, X.; Deng, H.; Azizad, D.; Hoffman, C.; Azizi, L.; Elezi, G.; Zhuang, Z.; Cardenas, A. M.; Calseron, C.; Mohammadi, M.; Tate, S.; Whitelegge, J. P.; Li, G.; Zuckerman, J.; Damoiseaux, R.; Bhaduri, A.; Liau, L.; Kornblum, H.; Jung, M. E.; Pajonk, F.
10.1101/2025.04.10.648292 — neuroscience — Posted on 2025-04-16
2584 Domain-general neural effects of associative learning and expectations on pain and hedonic taste perception
Zhao, Y.; Lee, I.; Rose-McCandlish, M.; Yu, Q.; Mischkowski, D.; Avery, J. A.; Ingeholm, J. E.; Reynolds, R. C.; Chen, G.; Atlas, L. Y.
10.1101/2025.04.10.648205 — neuroscience — Posted on 2025-04-16
2585 hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cells
Cardozo, P. L.; Lee, C.-Y.; Lacerda, J. P. S.; Fahel, J. S.; Trindade, P.; Vitoria, G.; Chicaybam, L.; Cordeiro, R. C.; de Faria, I. J. S.; Silva, N. C.; Todjro, Y. M. H.; Maciel, J. C. d. P.; Bonamino, M. H.; Vieira, L. B.; Cruz, B. F.; Nicolato, R.; Brennand, K. J.; Rehen, S. K.; Ribeiro, F. M.
10.1101/2024.09.20.614161 — neuroscience — Posted on 2025-04-16
2587 Sexually distinct multi omic responses to progressive endurance exercise training in the rat lung. Findings from MoTrPAC
Many, G.; Sagendorf, T. J.; Mitchell, H. D.; Sanford, J. A.; Cohen, S.; Misra, R.; Estevao, I. L.; Diaz Ludovico, I.; Gaul, D. A.; Lindholm, M. E.; Ushakumary, M. G.; Pino, J.; Musi, N.; Nie, J.; Fernandez, F.; Ortlund, E. A.; Esser, K. A.; Bodine, S. C.; Schenk, S.; Clair, G. C.; Adkins, J. N.
10.1101/2025.04.10.647997 — physiology — Posted on 2025-04-16
2588 Multi-behavioral phenotyping in early-life-stage zebrafish for identifying disruptors of non-associative learning
Leuthold, D.; Herold, N. K.; Nerlich, J.; Bartmann, K.; Scharkin, I.; Hallermann, S. J.; Schweiger, N.; Fritsche, E.; Tal, T.
10.1101/2024.09.25.613874 — pharmacology and toxicology — Posted on 2025-04-16
2589 New insights into the role of oxytocin signaling in preeclampsia
an, S.-M.; jeong, j.; kim, M.; kim, D.; kim, S.; kang, H.-G.; Kim, S.-C.; An, B.-s.
10.1101/2025.04.10.648289 — pathology — Posted on 2025-04-16
2593 Inferring non-coding RNA regulatory network from transcriptomic data and curated databases
MA, T.; Ke, H.; Ye, Z.; Feng, L.; Xu, Z.; Pan, R.; Li, E.; Qi, J.; Chen, S.; Liang, M.
10.1101/2025.04.10.648218 — bioinformatics — Posted on 2025-04-16
2602 Muc6-expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions
Arai, J.; Iwata, Y.; Tsubosaka, A.; Kinoshita, H.; Shinohara, S.; Abe, S.; Shiokawa, T.; Oura, K.; Suzuki, N.; Hata, M.; Kurokawa, K.; Oya, Y.; Tsuboi, M.; Ihara, S.; Murakami, K.; Shiomi, C.; Uekura, C.; Fujiwara, H.; Tateno, H.; Mizuno, S.; Takahashi, S.; Kanai, A.; Suzuki, Y.; Ushiku, T.; Ijichi, H.; Hirata, Y.; Kasuga, M.; O'Brien, V. P.; Salama, N.; Kakiuchi, M.; Ishikawa, S.; WANG, T. C.; Hayakawa, Y.; Fujishiro, M.
10.1101/2025.04.15.648856 — cell biology — Posted on 2025-04-16
2603 Macrophages Mediate Antiviral Immunity and Repair of Type 2 Alveolar Epithelial Cells in a Human Stem Cell Model
Turner, D. L.; Baric, H.; Patatsos, K.; Amoozadeh, S.; See, M.; Strumila, K. A.; Murphy, J. T.; Gubbels, L.; Ng, E.; Elefanty, A.; Neeland, M.; Shanthikumar, S.; Londrigan, S. L.; Ramialison, M.; Rossello, F. J.; Stanley, E.; Werder, R. B.
10.1101/2025.04.15.648867 — cell biology — Posted on 2025-04-16
2604 Mitochondrial fission during mitophagy requires both inner and outer mitofissins
Furukawa, K.; Maruyama, T.; Yamashita, S.-i.; Inoue, K.; Fukuda, T.; Noda, N. N.; Kanki, T.
10.1101/2025.04.13.648642 — cell biology — Posted on 2025-04-16
2605 P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity
Baker, M. J.; Hampson, E.; Islam, P.; Pelaez Moral, R.; Maunders, E. A.; Hornigold, K.; Tsonou, E.; Hornigold, D. C.; Hubbard, R. E.; Massey, A. J.; Welch, H. C. E.
10.1101/2025.04.14.648762 — cell biology — Posted on 2025-04-16
2606 Muscle spatial transcriptomic reveals heterogeneous profiles in untreated juvenile dermatomyositis and the persistence of pathological signature after remission
TRAGIN, M.; Periou, B.; Chaigne, B.; Bader-Meunier, B.; Barnerias, C.; Bodemere-Skandalis, C.; Desguerre, I.; Rodero, M.; AUTHIER, F. J.; GITIAUX, C.
10.1101/2025.04.15.648883 — cell biology — Posted on 2025-04-16
2607 M6A reader protein YTHDF3 regulates cardiomyocyte death and atrophy by modulating the alternative splicing program
Gaur, A.; Chaudhary, S.; Sharma, R. K.; Kundu, S.; E, G.; Kumari, R.; Singh, S.; Prakash, S.; Mitra, K.; Kumar, S.; Gupta, S. K.
10.1101/2025.04.15.648887 — cell biology — Posted on 2025-04-16
2608 Archaeal SegAB forms a bipolar structure that promotes chromosome segregation in spherical cells
Charles-Orszag, A.; Lord, S. J.; Herrera, N.; Strauskulage, L.; Bhowmick, A.; Goddard, T.; Wassmer, B.; van Wolferen, M.; Asper, G.; Flis, A.; Rodriguez, J.; Redding, S.; Rosenberg, O.; Albers, S.-V.; Mullins, D.
10.1101/2025.04.15.649018 — cell biology — Posted on 2025-04-16
2609 A Rosella-PLIN2 Knock-in Mouse Reveals Lipophagy and Immunometabolic Interplay in Atherosclerosis
Laval, T.; Joyce, N.; Boucher, D.; Rochon, V.; Emerton, C.; Dharia, M.; Robichaud, S.; Lorant, V.; Nguyen, M.-A.; Geoffrion, M.; Rayner, K. J.; Gibbings, D.; Nutter, L. M. J.; Russell, R. C.; Ouimet, M.
10.1101/2025.04.15.647781 — cell biology — Posted on 2025-04-16
2610 SND1 Impairs Calcium Homeostasis in Right Ventricular Failure by Binding and Destabilizing SERCA2a in Cardiomyocytes
Guo, L.; Liu, X.; Wang, L.; Li, Y.; Zhu, X.; Cheng, X.; Ye, C.; chen, n.; Li, L.; Qin, G.; Wang, Y.; Wang, D.; Qiu, J.; Wang, E.
10.1101/2025.04.14.648853 — cell biology — Posted on 2025-04-16
2611 Mechanisms of nuclear segregation in a multinucleate multibudding yeast
Petrucco, C. A.; Crocker, A. W.; Wirshing, A. C.; Colarusso, A. V.; Waarts, M.; Gladfelter, A. S.; Lew, D.
10.1101/2025.04.14.648742 — cell biology — Posted on 2025-04-16
2612 Clearance of protein aggregates during cell division
Du, S.; Wang, Y.; Chen, B.; Xie, S.; Chan, K. Y.; Hay, D. C.; Chew, T. G.
10.1101/2024.02.10.579754 — cell biology — Posted on 2025-04-16
2613 Investigating the role of molecular coating in human corneal endothelial cell primary culture using artificial intelligence-driven image analysis
TRAVERS, G.; COULOMB, L.; AOUIMEUR, I.; HE, Z.; BONNET, G.; OLLIER, E.; GAVET, Y.; MOISAN, A.; GAIN, P.; THURET, G.; MAURIN, C.
10.1101/2025.04.15.648927 — cell biology — Posted on 2025-04-16
2614 An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.
Ali, M.; Dura, R.; Guery, M.-A.; Colard-Itte, E.; Cheviet, T.; Robresco, L.; Berry, L.; Lionne, C.; Lavazec, C.; Claessens, A.; Peyrottes, S.; Wengelnik, K.; Wein, S.; Cerdan, R.
10.1101/2025.04.01.645218 — microbiology — Posted on 2025-04-16
2616 Integrative plasma lipidomics and proteomics profiling to decipher potential biomarkers of dilated cardiomyopathy
Saha, S.; Singh, P.; Dutta, A.; Raj, A.; Rathore, M.; Jindal, D.; Vaidya, H.; Kumari, S.; Negi, P. C.; Sengupta, S.; Seth, S.; Basak, T.
10.1101/2025.04.13.648582 — systems biology — Posted on 2025-04-16
2617 Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden
Michael, C. T.; Budak, M.; Maiello, P.; Kracinovsky, K.; Rodgers, M.; Tomko, J.; Lin, P. L.; Flynn, J. L.; Linderman, J. J.; Kirschner, D.
10.1101/2025.04.10.648004 — systems biology — Posted on 2025-04-16
2618 Apolipoprotein interaction induces shape remodeling and lipid phase separation in giant unilamellar vesicles
Carnahan, C. F.; He, W.; Ozturk, T. N.; Wang, Y.; Ngassam, V. N.; Noy, A.; Carpenter, T. S.; Voss, J. C.; Coleman, M. A.; Parikh, A. N.
10.1101/2025.04.10.648283 — biophysics — Posted on 2025-04-16
2623 Warm waters undermine cryptic female choice
Kustra, M. C.; Alissa, L. M.; Rogers, M. M.; Molinari, M. M.; Stiver, K. A.; Marsh-Rollo, S.; Hellmann, J. K.; Alonzo, S. H.
10.1101/2025.04.10.648287 — evolutionary biology — Posted on 2025-04-16
2625 GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers
van de Grift, Y. B.; Aarts, M. T.; Wiese, K. E.; Heijmans, N.; Hooijkaas, I. B.; Pritchard, C. E.; Henneman, L.; Krimpenfort, P. J.; van Boxtel, A. L.; van Amerongen, R.
10.1101/2025.04.11.648333 — developmental biology — Posted on 2025-04-16
2633 Mosquito sex under lock and key
Houri-Zeevi, L.; Walker, M. M.; Razzauti, J.; Sharma, A.; Pasolli, H. A.; Vosshall, L. B.
10.1101/2025.04.11.648401 — animal behavior and cognition — Posted on 2025-04-16
2635 The visual system of the longest-living vertebrate, the Greenland shark
Fogg, L. G.; Tom, E.; Policarpo, M.; Cho, W.; Gao, F.; Grieco, S. F.; Hii, D.; Fawcett, A. E.; Boileau, N.; Bech-Poulsen, A.; Steffensen, K. F.; Ng, C. J.; Bushnell, P. G.; Fleng Steffensen, J.; Brill, R.; Salzburger, W.; Skowronska-Krawczyk, D.
10.1101/2025.04.10.648203 — evolutionary biology — Posted on 2025-04-16
2636 IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster
Maasdorp, M. K.; Valanne, S.; Vesala, L.; Vornanen, P.; Haukkavaara, E.; Tuomela, T.; Malin, A.; Salminen, T. S.; Hultmark, D.; Rämet, M.
10.1101/2025.04.10.648149 — immunology — Posted on 2025-04-16
2638 Engineered protein circuits for cancer therapy
Lu, A. C.; Moeller, L.; Moore, S.; Xia, S.; Ho, K.; Zhang, E.; Budde, M. W.; Larson, H.; Ahmed Diaz, A.; Gu, B.; Linton, J. M.; Klock, L.; Flynn, M. J.; Gao, X. J.; Siegwart, D. J.; Zhu, H.; Elowitz, M. B.
10.1101/2025.04.16.647665 — synthetic biology — Posted on 2025-04-16
2643 InteracTor: Feature Engineering and Explainable AI for Profiling Protein Structure-Interaction-Function Relationships
Silva, J. C. F.; Schuster, L.; Sexson, N.; Erdem, M.; Hulk, R.; Kirst, M.; Resende, M. F. R.; Dias, R.
10.1101/2025.04.10.648139 — bioinformatics — Posted on 2025-04-16
2646 Polygenic Risk Scores Across Genomic Platforms for Reliable Breast Cancer Risk Stratification
Ho, P. J.; Khng, A. J.; Tan, J. H. J.; Goy, P.-A. V.; Kamila, K. A.; Li, Z.; Ho, W. K.; Tan, I. B. H.; Chong, D. Q.; Lo, E.; Goh, L. L.; Wee, H. L.; Hartman, M.; Dorajoo, R.; Bertin, N.; Li, J.
10.1101/2025.04.10.648141 — genetics — Posted on 2025-04-16
2648 Do identification guides hold the key to speciesmisclassification by citizen scientists?
Chadwick, F. J.; Haydon, D. T.; Husmeier, D.; Matthiopoulos, J. J.; Ovaskainen, O.
10.1101/2025.04.10.648156 — ecology — Posted on 2025-04-16
2651 Regulation of input excitability in human and mouse parvalbumin interneurons by Kir potassium channels
Furdan, S.; Douida, A.; Bakos, E.; Tiszlavicz, A.; Molnar, G.; Tamas, G.; Welter, D.; Landry, J.; H. Kovacs, B.; Erdelyi, M.; Bende, B.; Hutoczki, G.; Barzo, P.; Benes, V.; Szegedi, V.; Szucs, A.; Lamsa, K.
10.1101/2025.04.11.648314 — neuroscience — Posted on 2025-04-16
2653 Scaling unlocks broader generation and deeper functional understanding of proteins
Bhatnagar, A.; Jain, S.; Beazer, J.; Curran, S. C.; Hoffnagle, A. M.; Ching, K.; Martyn, M.; Nayfach, S.; Ruffolo, J. A.; Madani, A.
10.1101/2025.04.15.649055 — synthetic biology — Posted on 2025-04-16
2655 Precision RNAi in Tomato Using Synthetic Trans-Acting Small Interfering RNAs Derived From Minimal Precursors
Tomassi, A. H.; Juarez-Molina, M.; Cisneros, A. E.; Alarcia, A.; Toledano, S.; Orlando, F.; Presa, S.; Granell, A.; Carbonell, A.
10.1101/2025.04.10.648111 — plant biology — Posted on 2025-04-16
2657 Structures of Chaetomium thermophilum TOM complexes with bound preproteins
Agip, A.-N. A.; Ornelas, P.; Yang, T.-J.; Uboldi, E.; Haeder, S.; McDowell, M. A.; Kuehlbrandt, W.
10.1101/2025.04.16.649081 — biophysics — Posted on 2025-04-16
2663 Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion
Montagud-Marrahi, E.; Rodriguez-Gonzalo, A.; Lopez-Aladid, R.; Luque, Y.; Rabadan-Ros, R.; Cuadrado-Payan, E.; Banon-Maneus, E.; Rovira, J.; Lazo-Rodriguez, M.; Aguila, O.; Arana, C.; Garcia-Busquets, A.; Hierro, N.; Prudhomme, T.; Musquera, M.; Xia, Y.; Diekmann, F.; Campistol, J. M.; Ramirez-Bajo, M. J.
10.1101/2025.04.10.648123 — bioengineering — Posted on 2025-04-16
2664 Hybrid bioinks for embedded bioprinting of an artery model
Aizarna, U.; Herrero-Ruiz, A.; Caiado-Decarli, M.; Chavarri, K.; Moroni, L.; Henriksen-Lacey, M.; Jimenez de Aberasturi, D.
10.1101/2025.04.10.648100 — bioengineering — Posted on 2025-04-16
2667 Sperm storage reduces sperm and embryo quality in animals
Sanghvi, K.; Dean, R.; Nakagawa, S.; Reinhardt, K.; Sepil, I.; Vega-Trejo, R.
10.1101/2025.04.10.647966 — evolutionary biology — Posted on 2025-04-16
2668 Modelling the effects of adult emergence on the surveillance and age distribution of medically important mosquitoes
Stopard, I. J.; Sherrard-Smith, E.; Ranson, H.; Toe, K. H.; Cook, J.; Biggs, J. R.; Lambert, B.; Churcher, T. S.
10.1101/2025.04.10.648138 — ecology — Posted on 2025-04-16
2670 A glucosinolate-rich beverage lowers blood lactate concentrations during submaximal exercise
Vinge, F.; Tillqvist, E.; Horwath, O.; Apro, W.; Larsen, F. J.; Sundqvist, M. L.
10.1101/2025.04.15.648889 — physiology — Posted on 2025-04-16
2671 Improved detection of pre-symptomatic, non-central nervous system TDP-43 pathology in amyotrophic lateral sclerosis using RNA aptamer
Waldron, F. M.; Langerova, T.; Read, F. L.; Spence, H.; Hanna, K.; Roberts, K.; Pattle, S. B.; Gregory, J. M.
10.1101/2025.04.10.648122 — pathology — Posted on 2025-04-16
2672 Comparative population genomics reveals convergent adaptation across independent origins of avian obligate brood parasitism
Osipova, E.; Balakrishnan, C. N.; Spottiswoode, C. N.; Lund, L.; DaCosta, J. M.; Hauber, M. E.; Warren, W. C.; Sorenson, M. D.; Sackton, T. B.
10.1101/2025.04.08.647876 — evolutionary biology — Posted on 2025-04-16
2673 Anatomical and Molecular Characterization of the Zebrafish Meninges
Venero Galanternik, M.; Castranova, D.; Gober, R. D.; Nguyen, T.; Kenton, M.; Margolin, G.; Kraus, A.; Sur, A.; Dye, L. E.; Pham, V.; Maese, A.; Holmgren, M.; Gore, A. V.; Samasa, B.; Goldstein, A.; Davis, A. E.; Swearer, A. A.; Iben, J. R.; Li, T.; Coon, S. L.; Dale, R. K.; Farrell, J. A.; Weinstein, B. M.
10.1101/2025.04.09.646894 — developmental biology — Posted on 2025-04-16
2674 Comprehensive annotation of olfactory and gustatory receptor genes and transposable elements revealed their evolutionary dynamics in aphids
Olvera-Vazquez, S. G.; Chen, X.; Mesnil, A.; Meslin, C.; Almeida-Silva, F.; Confais, J.; Bourgeois, Y.; Lougmani, C.; Alix, K.; Choisne, N.; Cauet, S.; Simon, J. C.; Buchard, C.; Rodde, N.; Ogereau, D.; Mottet, C.; Degrave, A.; Segura, E.; Barres, B.; Jacquin-Joly, E.; Marande, W.; Lavenier, D.; Legeai, F.; Cornille, A.
10.1101/2025.04.14.648604 — molecular biology — Posted on 2025-04-16
2675 Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response
Ruger-Herreros, C.; Svoboda, L.; Male, G.; Srivastava, A.; Höpfner, M.; Jetzinger, K.; Koubek, J.; Kramer, G.; den Brave, F.; Mogk, A.; Gross, D. S.; Bukau, B.
10.1101/2025.04.14.648540 — molecular biology — Posted on 2025-04-16
2677 LPS/TLR4-Activating Exosomes from M1-Polarized Avian Macrophages Enhances IBV Vaccine-Induced Protective Immunity in Chickens
Zhou, J.; Cai, S.; Huang, H.; Yang, F.; Pan, K.; Sun, Z.; Chen, Y.; Fan, Y.; Wen, F.; QIN, L.; Zhang, Y.
10.1101/2025.04.08.647822 — immunology — Posted on 2025-04-16
2680 Can social interactions rescue "lost" behavioural defences in an allopatric cuckoo host?
Tolman, D.; Rönkä, K.; Kluen, E.; Jolkkonen, J.; Di Bari, P.; Ientile, R.; Campobello, D.; Thorogood, R.
10.1101/2024.01.14.575589 — animal behavior and cognition — Posted on 2025-04-16
2684 Amino acid restriction sensitizes lung cancer cells toferroptosis via GCN2-dependent activation of the integratedstress response
Garrelick, V. J.; Gul, N.; Horrieh, P.; Mustafa, D.; Patel, A. A. H.; Dankis, M.; Alvarez, S. W.; Berndtson, J.; Schwarz, M.; Persson, A.; Zahirovic, F.; Wiel, C.; Sayin, V. I.; Lindahl, P.
10.1101/2025.04.10.648120 — cancer biology — Posted on 2025-04-16
2685 Estimating full-field displacement in biological images using deep learning
Warsop, S. J. E. T.; Caixeiro, S.; Bischoff, M.; Kursawe, J.; Bruce, G. D.; Wijesinghe, P.
10.1101/2024.05.21.595161 — biophysics — Posted on 2025-04-16
2686 IntegrAlign: A comprehensive tool for multiimmunofluorescence panel integration through image alignment
Hermet, L.; Laoubi, L.; Scavino, M.; Doffin, A.-C.; Gazeu, A.; Justine, B.; Pillat, B.; Tissot, S.; Rusakiewicz, S.; Michallet, M.-C.; Bendriss-Vermare, N.; Valladeau-Guilemond, J.; Hausser, J.; Caux, C.; Hubert, M.
10.1101/2025.04.10.648082 — bioinformatics — Posted on 2025-04-16
2689 Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation
Malita, A.; Skakkebaek, A. H.; Kubrak, O.; Chen, X.; Koyama, T.; Connolly, E. C.; Ahrentloev, N.; Andersen, D. S.; Texada, M. J.; Halberg, K.; Rewitz, K.
10.1101/2024.06.25.600726 — animal behavior and cognition — Posted on 2025-04-16
2690 Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution
Foster, C. S. P.; Walker, G. J.; Jean, T.; Wong, M.; Brassil, L.; Isaacs, S.; Lu, Y.; Turville, S. G.; Kelleher, A.; Rawlinson, W. D.
10.1101/2023.11.02.565396 — evolutionary biology — Posted on 2025-04-16
2694 Hippocampus facilitates reinforcement learning in partially observable environments
Pedamonti, D.; Mohinta, S.; Dimitrov, M.; Malagon-Vina, H.; Ciocchi, S.; Costa, R. P.
10.1101/2023.11.09.565503 — neuroscience — Posted on 2025-04-16
2697 A lipidomic exploration of the effects of high-intensity interval exercise in healthy men after metformin intake
Neuhaus, R.; Meikopoulos, T.; Gradillas, A.; Gonzalez-Riano, C.; Theodoridis, G.; Nikolaidis, S.; Mougios, V.; Barbas, C.; Gika, H.; VILLASENOR, A.
10.1101/2025.04.02.646809 — systems biology — Posted on 2025-04-16
2701 A multicellular actin star network underpins epithelial organization and connectivity
Barai, A.; Soleilhac, M.; Xi, W.; Lin, S.-Z.; Karnat, M.; Bazellieres, E.; Richelme, S.; Lecouffe, B.; Chardes, C.; Berrebi, D.; Ruemmele, F.; Thery, M.; Rupprecht, J.-F.; Delacour, D.
10.1101/2024.07.26.605277 — cell biology — Posted on 2025-04-16
2702 Cytosine Methylation is a marker of Viral Gene Transfer across the eukaryotes
Sarre, L. A.; Gastellou Peralta, G. A.; Romero Charria, P.; Ovchinnikov, V.; de Mendoza, A.
10.1101/2025.04.15.648976 — genomics — Posted on 2025-04-16
2703 Short-term coastal forest responses to a hurricane-scale freshwater and saltwater flooding experiment
Myers-Pigg, A.; Hopple, A.; Pennington, S. C.; Regier, P.; Bond-Lamberty, B.; DiCianna, M. J.; Doro, K. O.; McDowell, N.; McElhinny, J.; Stearns, A.; Ward, N. D.; Bailey, V. L.; Megonigal, J. P.
10.1101/2025.04.13.648622 — ecology — Posted on 2025-04-15
2704 The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair.
Joyce, C. M.; Bacal, J.; Chowdhury, S. P.; Brown, A. N.; Wang, A. K.; Cruz, C.; Bains, K.; Rodriguez, Z. N.; McCormick, N. J.; Tzadikario, Y.; Tavasoli, K. U.; Gardner, B. M.; Richardson, C. D.
10.1101/2025.04.15.648866 — cell biology — Posted on 2025-04-16
2705 Metatranscriptomic Insights into Microbial Dynamics Prior to Disease Onset in Atlantic Salmon Aquaculture
Harding, A.; Diblasi, C.; Manousi, D.; Soung Kwak, J.; Hazlerigg, D. G.; Morkore, T.; Snippen, L. G.; de Leon, A. V.-P.; Saitou, M.
10.1101/2025.04.15.648526 — microbiology — Posted on 2025-04-15
2706 New high accuracy diagnostics for avian Aspergillus fumigatus infection using Nanopore methylation sequencing of host cell-free DNA and machine learning prediction
Drag, M. H.; Hvilsom, C.; Poulsen, L. L.; Jensen, H. E.; Tahas, S. A.; Leineweber, C.; Cray, C.; Bertelsen, M. F.; Bojesen, A. M.
10.1101/2025.04.11.648151 — microbiology — Posted on 2025-04-15
2707 Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups
Luquez, T.; Algoo, J.; Chiu, R.; Mares, J. A.; Yadav, A.; Lam, M.; Gaur, P.; Lai, X.; Lee, D. I.; Paryani, F.; Batchelor, R.; Belli, I.; Henry, J.; Mattison, C.; Starr, L.; De Jager, P. L.; Barnes, L. L.; Marquez, D. X.; Zhang, Y.; Bennett, D. A.; Menon, V.
10.1101/2025.04.14.648597 — neuroscience — Posted on 2025-04-15
2708 Molecular insights into early malignant transition of hepatocellular carcinoma
Hui, L.; Zhang, Z.; Li, H.; Chen, L.; Lu, T.; Shentu, X.; Liu, Y.; Ji, S.; Qiu, Z.; Zou, Y.; Wen, H.; Han, J.; Jiang, Z.; Fan, J.; Li, D.; Mesropian, A.; Pinyol, R.; Llovet, J. M.; Dong, H.; Ji, Y.
10.1101/2025.04.14.648739 — cancer biology — Posted on 2025-04-15
2711 Human sand fly challenge elicits saliva-specific innate and TH1-polarized immunity that promotes Leishmania killing
Abdeladhim, M.; Teixeira, C.; Ressner, R.; Hummer, K.; Dey, R.; Gomes, R.; de Castro, W.; de Araujo, F. F.; Turiansky, G. W.; Iniguez, E.; Meneses, C.; Oliveira, F.; Aronson, N.; Lacsina, J. R.; Valenzuela, J. G.; Kamhawi, S.
10.1101/2025.02.25.640210 — immunology — Posted on 2025-04-15
2713 Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases
Finney, J.; Kuraoka, M.; Song, S.; Watanabe, A.; Liang, X.; Liao, D.; Moody, M. A.; Walter, E. B.; Harrison, S.; Kelsoe, G. H.
10.1101/2025.01.01.631020 — immunology — Posted on 2025-04-15
2714 Ethylene and ROS Signaling Are Key Regulators of Lateral Root Development under Salt Stress in Tomato
Rahmati Ishka, M.; Zhao, J.; Sussman, H.; Mohanty, D.; Craft, E.; Yu, L.; Pineros, M.; Tester, M.; Kawa, D.; Mittler, R.; Nelson, A.; Fei, Z.; Julkowska, M. M.
10.1101/2024.06.20.599848 — plant biology — Posted on 2025-04-15
2716 3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions
Harun, A.; Bendele, N.; Khalil, M. I.; Vasquez, I.; Djuanda, J.; Posey, R.; Rashid, H.; Christopher, G.; Bickel, U.; Gruev, V.; Tropp, J.; Egan, P.; Srivastava, I.
10.1101/2025.02.01.636085 — bioengineering — Posted on 2025-04-15
2717 Structural Heterogeneity of Proteoform-Ligand Complexes in AMP-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry
Chan, H.-J.; Krichel, B.; Bandura, L. J.; Chapman, E. A.; Rogers, H. T.; Fischer, M. S.; Roberts, D. S.; Gao, Z.; Wang, M.-D.; Wu, J.; Uetrecht, C.; Jin, S.; Ge, Y.
10.1101/2025.04.15.648965 — biochemistry — Posted on 2025-04-15
2718 ESBL plasmid compatibility with the surrounding microbial community influences ESBL gene survival under CRISPR-antimicrobial targeting
Given, C.; Jonsdottir, I.; Norvasuo, K.; Paananen, P.; Ruotsalainen, P.; Hiltunen, T.; Gunell, M.; Hakanen, A. J.; Jalasvuori, M.; Penttinen, R.
10.1101/2025.04.15.648872 — microbiology — Posted on 2025-04-15
2719 Reducing the impact of HaHV-1 in Australian abalone: the role of age and immune priming
Agius, J. R.; Ackerly, D.; Watson, A. C.; Smith, M. L.; Beddoe, T.; Helbig, K.
10.1101/2025.04.14.648835 — microbiology — Posted on 2025-04-15
2721 Reinforced CRISPR interference enables reliable multiplex gene repression in phylogenetically distant bacteria
Elmore, J. R.; Shrestha, R.; Wilson, A.; Francis, R.; Baldino, H.; Van Fossen, E. M.; Frank, A.; Stephenson, M.; Gupta, B.; Rivera, J.; Egbert, R.
10.1101/2025.04.14.648646 — microbiology — Posted on 2025-04-15
2723 The accessory type III secretion system effectors shape intestinal inflammatory infection outcomes
Biswas, P.; Sanchez-Garrido, J.; Kozik, Z.; Mishra, V.; Ruano-Gallego, D.; Berkachy, R.; Jordan, S.; Wong, J. L. C.; Choudhary, J. S.; Frankel, G.
10.1101/2025.04.15.648969 — microbiology — Posted on 2025-04-15
2726 Novel multi-transmitter calyx-like giant synapse revealed in the extended amygdala
Zhang, L.; Hernandez, V. S.; Giraldo, D. M.; Leon-Contreras, J. C.; Ye, R.; Zhang, S.; Schafer, M. K.-H.; Barrio, R. A.; Hernandez-Pando, R.; Ferraguti, F.; Eiden, L. E.
10.1101/2025.04.03.647119 — neuroscience — Posted on 2025-04-15
2729 EVOFLOW-RNA: GENERATING AND REPRESENTING NON-CODING RNA WITH A LANGUAGE MODEL
Patel, S.; Peng, F. Z.; Fraser, K.; Friedman, A. D.; Chatterjee, P.; Yao, S.
10.1101/2025.02.25.639942 — synthetic biology — Posted on 2025-04-15
2733 Diploid genome assembly of human fibroblast cell lines enables clone specific variant calling, improved read mapping and accurate phasing
Ranallo-Benavidez, T. R.; Hao, Y.; Volpe, E.; Jehangir, M.; Fukushima, N.; Mbegbu, O.; Reiman, R.; Molnar, J.; Murphy, D.; Paredes, D. M.; Wong, S.; Karaniuk, K.; Buchholtz, S.; Keats, J.; Machiela, M. J.; Kolmogorov, M.; Paten, B.; Giunta, S.; Barthel, F. P.
10.1101/2025.04.15.648829 — genomics — Posted on 2025-04-15
2737 Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation
Klein, R.; Onyuru, J.; Centa, J. L.; Viera, E. M.; Putnam, C. D.; Hoffman, H. M.; Hastings, M. L.
10.1101/2024.09.06.611206 — molecular biology — Posted on 2025-04-15
2738 ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei
Chen, Y.; Toufektchan, E.; Luan, X.; Hickling, J.; Norman, R. X.; Cifani, P.; Kentsis, A.; Zhou, W.; Maciejowski, J.
10.1101/2025.04.14.648782 — molecular biology — Posted on 2025-04-15
2744 Deciphering the RNA-based regulation mechanism of the phage-encoded AbiF system in Clostridioides difficile
Saunier, M.; Humbert, A.; Kreis, V.; Peltier, J.; Tisba, A.; Auxilien, S.; Blum, M.; Caldelari, I.; Lucier, J.-F.; Ueda, J.; Gautheret, D.; Toffano-Nioche, C.; Andreani, J.; Fortier, L.-C.; SOUTOURINA, O.
10.1101/2025.04.15.648962 — microbiology — Posted on 2025-04-15
2747 Expanding the chicken gut virome: Uncovering viral diversity, host interactions, and regional variations across the intestinal tract
Zhao, J.-X.; Ni, H.-B.; Nan, F.-L.; Yan, Q.; Li, S.; Su, J.-W.; Cai, Y.; Meng, J.-X.; Yu, H.-L.; Shang, K.-M.; Liu, R.; Hou, X.-W.; Elsheikha, H. M.; Ma, H.; Zhang, X.-X.
10.1101/2025.04.15.647674 — microbiology — Posted on 2025-04-15
2748 Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strains
Gartner, M. J.; Smith, M. J.; Dapat, C.; Liaw, Y. W.; Tran, T.; Suryadinata, R.; Chen, J.; Sun, G.; Shepard, R. A.; Taiaroa, G.; Roche, M.; Lee, W. S.; Robinson, P.; Polo, J. M.; Subbarao, K.; Neil, J. A.
10.1101/2025.04.13.648626 — microbiology — Posted on 2025-04-15
2750 Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors
Ozkan, A.; Padmanabhan, H. K.; Shipman, S.; Azim, E.; Kumar, P.; Sadegh, C.; Basak, N.; Macklis, J. D.
10.1101/2024.04.21.590488 — neuroscience — Posted on 2025-04-15
2754 Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations
Rampy, J.; Torres-Manzo, A. P.; Hoffsmith, K.; Loberg, M. A.; Sheng, Q.; Salas-Lucia, F.; Bianco, A. C.; Arrojo e Drigo, R.; Wang, H.; Weiss, V. L.; Carrasco, N.
10.1101/2025.03.31.645596 — physiology — Posted on 2025-04-15
2755 The ribosome directs nascent chains through two folding-dependent pathways
Mitropoulou, A. N.; Wlodarski, T.; Streit, J. O.; Chan, S. H. S.; Plessa, E.; Woodburn, L. F.; Cabrita, L. D.; Christodoulou, J.
10.1101/2025.04.08.647855 — biophysics — Posted on 2025-04-15
2756 Covering All Bases: A Computational Method to Design Broad-spectrum T-cell-inducing Vaccines Applied to Betacoronaviruses
Palmer, P.; Fedosyuk, S.; Parthasarathy, S.; Holbrook, J.; George, C.; O'Reilly, L.; Wiegand, L.; Carnell, G. W.; Heeney, J. L.; Vishwanath, S.
10.1101/2025.04.14.648815 — bioinformatics — Posted on 2025-04-15
2758 Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1
Luna, S. E.; Feist, W. N.; Ben-Efraim, K.; Amorin, N. A.; Johnston, N. M.; Ghanim, H. Y.; Ekman, F. K.; Dudek, A. M.; Porteus, M. H.
10.1101/2025.04.14.648845 — bioengineering — Posted on 2025-04-15
2760 An integrated and scalable rodent cage system enabling continuous computer vision-based behavioral analysis and AI-enhanced digital biomarker development
Robertson, T. L.; Ellis, M.; Bratcher-Petersen, N. A.; Ruidiaz, M. E.; Harada, K.; Toburen, D.; Oberhauser, J. P.; Grzenda, D.; Peltier, N.; Raza, M.; Benway, J.; Kiros, J.; Kumar, V.
10.1101/2024.12.18.629281 — animal behavior and cognition — Posted on 2025-04-15
2762 Reduced frequency of clonal hematopoiesis in Parkinson's disease
Sun, S.; Sproviero, D.; Payan-Gomez, C.; Huang, Z.; Hoeijmakers, J. H. J.; Maslov, A. Y.; Mastroberardino, P. G.; Vijg, J.
10.1101/2023.05.04.539397 — genetics — Posted on 2025-04-15
2763 Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry
Eggeler, F.; Boulanger-Weill, J.; De Santis, F.; Belleri, L.; Duroure, K.; Auer, T. O.; Albadri, S.; Del Bene, F.
10.1101/2023.11.23.568438 — developmental biology — Posted on 2025-04-15
2764 RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis
Han, A.; Yermalovich, A.; Najia, M. A. T.; Pearson, D. S.; Fujiwara, Y.; Bolgov, M.; Kubaczka, C.; North, T. E.; Lundin, V.; Orkin, S.; Daley, G. Q.
10.1101/2025.04.03.647020 — developmental biology — Posted on 2025-04-15
2771 American black bear (Ursus americanus) as a potential host for Campylobacter jejuni
Parker, C. T.; Kathariou, S.; Miller, W. G.; Huynh, S.; Pascoe, B.; Cooper, K.
10.1101/2025.04.14.648838 — microbiology — Posted on 2025-04-15
2772 Mapping gene expression across the microbiome-gut-brain axis of germ- and specific pathogen-free mice
Dritsa, C.; Hoffmann, S.; Hulme, H.; Lynch, C.; Taylor, V.; Burchmore, R.; Cole, J.; Goodwin, R. J. A.; Wall, D. M.
10.1101/2025.04.15.648950 — microbiology — Posted on 2025-04-15
2777 Earlier snowmelt reduces the strength of carbon sink in montane meadows
Vought, O.; Kivlin, S.; Shulman, H.; Sorensen, P.; Inouye, D.; Ibanez, I.; Falb, P.; Rand, K.; Classen, A.
10.1101/2025.04.09.648035 — ecology — Posted on 2025-04-15
2778 Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates.
Rouzeau, R.; Schmidt, H. R.; Deal, C.; Allen, J. D.; Dudley, D. M.; Burton, I.; Rakasz, E. G.; Plante, O.; Crispin, M.; Carfi, A.; Sok, D.
10.1101/2025.04.09.648023 — immunology — Posted on 2025-04-15
2779 Induction of Resident Memory CD8+T cell Phenotypes to Eliminate the HIV reservoir
Mancebo Perez, C.; Benitez Rodriguez, A.; Tsukalov, I.; Grau Exposito, J.; Castellvi, J.; Manalich Barrachina, L.; Suanzes, P.; Navarro, J.; Burgos, J.; Curran, A.; Centeno Mediavilla, C.; Falco, V.; Martin Gayo, E.; Buzon, M. J.; Genesca, M.
10.1101/2025.04.09.647906 — immunology — Posted on 2025-04-15
2780 Disturbing immune homeostasis by neutrophil loss of Uba1 induces VEXAS-like autoinflammatory disease in mice
Dong, G.; Liu, J.; Zhou, H.; Jin, W.; Wen, Y.; Wang, Z.; Xia, K.; Zhang, J.; Ma, L.; Ma, Y.; Cai, L. C.; Zhou, Q.; Wang, H.; Wei, W.; Fu, Y.; CAI, Z.
10.1101/2025.04.09.648068 — immunology — Posted on 2025-04-15
2787 Lost in a Large EEG Multiverse? Comparing Sampling Approaches for Representative Pipeline Selection
Short, C. A.; Hildebrandt, A.; Bosse, R.; Debener, S.; Oezyagcilar, M.; Paul, K.; Wacker, J.; Kristanto, D.
10.1101/2025.04.08.647779 — neuroscience — Posted on 2025-04-15
2788 A biGWAS strategy reveals the genetic architecture of the interaction between wheat and Blumeria graminis f. sp. tritici
Xie, J.; Luo, Q.; Wang, L.; Qiu, D.; Zhao, C.; Hu, J.; Zhang, J.; Zhao, X.; Chen, Z.; Wang, Y.; Yu, Y.; Luo, M.; Song, H.; Hou, Y.; Zhang, Z.; Yin, M.; Wang, H.; Li, X.; Fu, X.; Xiao, B.; Li, Y.; Wu, J.; Liu, W.; Wang, Y.; Zhu, M.; Zhang, Y.; Fernie, A. R.; Wang, W.; Li, H.; He, F.
10.1101/2025.04.09.647224 — genomics — Posted on 2025-04-15
2791 The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis
Vuille, J. A.; Tanriover, C.; Micalizzi, D. S.; Ebright, R. Y.; Animesh, S.; Morris, R.; Hajizadeh, S.; Nicholson, Z. J.; Russell, H. C.; Zaniewski, E. F.; Wittner, B. S.; Wesley, B. K.; Grunewald, J.; Szalay, R. N.; Antmen, E.; Fox, D. B.; Yang, M.; Joung, J. K.; Gulhan, D. C.; Elia, A. E. H.; Haas, W.; Oh, E.; Maheswaran, S.; Haber, D. A.
10.1101/2025.04.09.647907 — cancer biology — Posted on 2025-04-15
2792 Tumoral CD24 tunes platelets binding and pro-metastatic functions
Mittelheisser, V.; Liboni, C.; Mouriaux, C.; Trivigno, S. M. G.; Bochler, L.; Garcia-Leon, M.; Larnicol, A.; Paulen, L.; Stemmelen, T.; Mangin, P. H.; Lefebvre, O.; GOETZ, J. G.
10.1101/2025.04.09.648049 — cancer biology — Posted on 2025-04-15
2795 Identification of genetic variation associated with high-temperature tolerance in cowpea
Akakpo, R.; Lee, E. J.; Pacheco, J. B.; Rios, E.; Kantar, M. B.; Boukar, O.; Volz, K. M.; Akinmade, H.; Luis, G.; Boote, K. J.; Munoz-Amatriain, M.; Morrell, P. L.
10.1101/2025.04.09.647789 — evolutionary biology — Posted on 2025-04-15
2796 Rapid expansion of synaptic complexity as a key contributor to cognitive growth in early humans
Lepski, G.; Arevalo, A.; Silva de Camargo, P.; Nunes, K.; Barbosa Lemes, R.; Ferraz, T.; Strauss, A.; Miyagawa, S.
10.1101/2025.04.09.648028 — evolutionary biology — Posted on 2025-04-15
2799 Systematic contextual biases in SegmentNT relevant to all nucleotide transformer models
Ebbert, M. T. W.; Ho, A.; Dutch, B.; Page, M. L.; Byer, B. K.; Hankins, K. L.; Sabra, H.; Aguzzoli Heberle, B.; Wadsworth, M. E.; Fox, G. A.; Karki, B.; Hickey, C.; Fardo, D. W.; Bumgardner, C.; Jakubek, Y. A.; Steely, C. J.; Miller, J. B.
10.1101/2025.04.09.647946 — bioinformatics — Posted on 2025-04-15
2800 Deep genomic models of allele-specific measurements
Mostafavi, S.; Tue, X.; Sasse, A.; Chowdhary, K.; Spiro, A.; Wang, L.; Chikina, M.; Benoist, C.
10.1101/2025.04.09.648060 — bioinformatics — Posted on 2025-04-15
2803 Trophic Transfer of Perfluoroalkyl Acids in a Periphyton-Mayfly-Zebrafish Food Chain
Farrell, M. R.; Buchwalter, D. B.; Weed, R. A.; Enders, J. R.; Planchart, A.
10.1101/2025.04.09.647996 — ecology — Posted on 2025-04-15
2808 Superior colliculus coordinates whole-brain dynamics for sudden unconscious visual insight
Murata, T.; Kunishige, K.; Seno, S.; Ohzawa, I.; Kaneko, K.; Yanagida, T.; Haruno, M.; Hosoda, K.
10.1101/2025.04.09.648050 — neuroscience — Posted on 2025-04-15
2809 Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons
Uhelski, M. L.; Schaub, M. K.; Espinosa, F.; Heles, M.; Cortes-Mejia, N. A.; Li, Y.; Tatsui, C. E.; Rhines, L. D.; Alvarez-Breckendridge, C.; Funk, G.; Horton, P.; Cervantes, A.; Lesnak, J. B.; Curatolo, M.; Dussor, G.; Price, T. J.; Dougherty, P. M. M.
10.1101/2025.04.09.648014 — neuroscience — Posted on 2025-04-15
2810 Amyloid fibrils in Alzheimer's disease differently modulate sleep and cortical oscillations in mice depending on the type of amyloid
Sanagi, T.; Okumura, M.; Lin, Y.; Kanemura, S.; Moon, E.; Heo, Y.; Takahara, K.; Tsunematsu, T.; Lee, Y.-H.
10.1101/2025.04.09.647928 — neuroscience — Posted on 2025-04-15
2814 Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli
Vystrcilova, M.; Sridhar, S.; Burg, M. F.; Khani, M. H.; Karamanlis, D.; Schreyer, H. M.; Ramakrishna, V.; Krüppel, S.; Zapp, S. J.; Mietsch, M.; Gollisch, T.; Ecker, A. S.
10.1101/2025.04.09.647910 — systems biology — Posted on 2025-04-15
2816 A knowledge graph and topological data analysis framework to disentangle the tomato-multi pathogens complex gene regulatory network
multari, m.; carriere, m.; Amoros-Gabarron, x.; damy, a.; lobentanzer, s.; saez-rodriguez, J.; Jaubert, S.; Dugourd, A.; BOTTINI, S.
10.1101/2025.04.09.647963 — systems biology — Posted on 2025-04-15
2817 Exercise-Induced Myostimulin Enhances Muscle Function in Health and Disease
Hillger, F.; Keller, H.; Furrer, A.; Melly, S.; Boesch, J.; Seddik, S.; Pierrel, E.; Bello, F.; Scharenberg, M.; Leber, X.; Hug, C.; Vicart, A.; Greiner, G.; Meyer, A.; Cobos-Correa, A.; Kaufmann, M.; Aschenbrenner, D.; Allard, C.; Delucis-Bronn, C.; Killmer, S.; Hils, L.; Rothen, J.; Lemire, S.; Altorfer, M.; Lambert, C.; Doelemeyer, A.; Accart, N.; Bepperling, A.; Weiss, L.; Burget, A.; Couttet, P.; Parker, C. N.; Rooks, D.; Kneissel, M.; Summermatter, S.
10.1101/2025.04.09.647960 — physiology — Posted on 2025-04-15
2818 Accelerated plastic aging in suspension (APAS): A simple, reproducible approach for the generation of model micro- and nanoplastics through simulated environmental forces
Lelliott, P. M.; Lindley, M.; Vidallon, M.; Hobro, A.; Eliason, A. D.; Moreno-Caceres, S.; Samandra, S.; Harrison, T.; Harper, R.; Trepout, S.; Devineau, S.; Clarke, B.; Smith, N. I.; Wang, X.; Marciano, D.; Pinto, A. R.
10.1101/2025.04.09.647903 — pharmacology and toxicology — Posted on 2025-04-15
2823 Proteomic Remodeling During Tumor Cell-Induced Platelet Aggregation Unveils Metastatic Drivers in Colorectal Cancer
Sauer, T.; Gruner, C.; Kern, K.; Rackisch, A.; Tischner, L.; Schulz, K.; Ostermann, J.; Cohrs, L.; Kohl, M.; Verschoor, A.; Gemoll, T.
10.1101/2025.04.09.647951 — cancer biology — Posted on 2025-04-15
2827 Wnt/β-catenin signalling assists cell fate decision making in the early mouse embryo
Lilao-Garzon, J.; Corujo-Simon, E.; Vinyoles, M.; Fischer, S. C.; Guillen, J.; Balayo, T.; Munoz-Descalzo, S.
10.1101/2025.04.09.647220 — developmental biology — Posted on 2025-04-15
2828 Cranial suture integrity is maintained by Fgfr3 in zebrafish
Pereur, R.; Marc, Y.; Lim, Y.; Schmitt, A.; Malbouyres, M.; Chessel, A.; Ruggiero, F.; Schanne-Klein, M.-C.; Legeai-Mallet, L.; Dambroise, E.
10.1101/2025.04.09.647929 — developmental biology — Posted on 2025-04-15
2829 Decoding stimulus-specific regulation of promoter activity of p53 target genes
Vigliotti, F.; Engelmann, N.; Sinzger-DAngelo, M.; Koeppl, H.; Loewer, A.
10.1101/2025.04.09.647556 — systems biology — Posted on 2025-04-15
2830 A simple, fast and cost-efficient protocol for ultra-sensitive ribosome profiling
Koubek, J.; Jetzinger, K.; Dror, S.; Irastortza-Olaziregi, M.; Frank, D.; Kotan, I.; Santos, J.; Tippmann, F.; Lafrenz, P.; Kaessmann, H.; Amster-Choder, O.; Bukau, B.; Kramer, G.
10.1101/2025.04.09.647970 — systems biology — Posted on 2025-04-15
2832 Chemical inhibition of RPA gap protection sensitizes BRCA1-deficient cancers to PARP inhibition
VanderVere-Carozza, P. S.; Jordan, M. R.; Garrett, J. E.; Pollok, K. E.; Hinshaw, H. D.; Sulaiman, X.; Liu, S.; Wan, J.; Pawelczak, K. S.; Turchi, J. J.
10.1101/2025.04.09.647957 — cancer biology — Posted on 2025-04-15
2835 Taming Darwin's conundrum: On the role of phylogenetic and functional differentiation in plant naturalization on oceanic islands
Arjona, Y.; Jay-Garcia, L. S.; Reyes-Betancort, J. A.; Morente-Lopez, J.; Salas-Pascual, M.; Naranjo-Cigala, A.; Sicilia-Pasos, G.; Padron-Mederos, M. A.; Orihuela-Rivero, R.; Gonzalez-Montelongo, R.; Patino, J.
10.1101/2025.04.09.648018 — ecology — Posted on 2025-04-15
2836 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.
Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devarakonda, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J.; Skeath, J.; Lacin, H.
10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-04-15
2837 Immunological characterization of peritoneal exudate cells in liver cirrhosis patients
Kaji, S.; Sasaki, I.; Kunimoto, S.; Wakaki-Nishiyama, N.; Tosuji, E.; Kurara, A.; Kato, T.; Mutsukawa, C.; Okuzaki, D.; Okamoto, C.; Yamano, Y.; Shimizu, R.; Maeshima, S.; Ida, Y.; Yamashita, Y.; Hashimoto, T.; Iwabuchi, S.; Hashimoto, S.; Saitoh, S.-I.; Araki, S.-i.; Kitano, M.; Kaisho, T.
10.1101/2025.02.19.638957 — immunology — Posted on 2025-04-15
2839 FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice
Sonrier, C.; Sar, C.; Melo, I.; Diouloufet, L.; Lucena-Silva, G. V.; Mallie, S.; Bertin, J.; Leyris, J.-P.; Ango, F.; Cunha, T. M.; Moha ou Maati, H.; Valmier, J.; Rivat, C.; Mechaly, I.
10.1101/2025.04.09.648037 — neuroscience — Posted on 2025-04-15
2840 Nucleus raphe magnus serotonin neurons bidirectionally control spinal mechanical pain transmission
Grivet, Z.; Verboven, A.; Aby, F.; Benazzouz, R. B.; Dhellemmes, T.; Perrot, E.; Beyeler, A.; Heisler, L. K.; Balia, M.; Battefeld, A.; martin, h.; Fioramonti, X.; Landry, M.; De Koninck, Y.; Benazzouz, A.; Fossat, P.
10.1101/2025.04.09.647804 — neuroscience — Posted on 2025-04-15
2841 Advection versus diffusion in brain ventricular transport
Herlyng, H.; Ellingsrud, A. J.; Kuchta, M.; Jeong, I.; Rognes, M. E.; Jurisch-Yaksi, N.
10.1101/2025.04.15.648743 — neuroscience — Posted on 2025-04-15
2845 The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis
Gomez-Munoz, M. A.; Karz, A.; Navarro, M.; Osorio-Vasquez, V. M.; Katsara, O.; Walker, A.; Berico, P.; Medellin, A. P.; Eskow, N. M.; Wan, Y.; Ibrahim, M.; Tagore, S.; DSouza, E. K.; Izar, B.; Vega-Saenz de Miera, E.; Osman, I.; Pacold, M.; Kong, X.; Levesque, M.; Possemato, R.; Holmen, S.; Schneider, R.; Vincent, T.; Ruggles, K.; Biancur, D.; Hernando, E.
10.1101/2025.03.18.644053 — cancer biology — Posted on 2025-04-15
2846 An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6
Capraro, F.; Abis, G.; Incocciati, A.; Karimzadeh, M.; Masino, L.; Barley, A.; Bui, T. T. T.; Kelly, G.; Goodarzi, H.; Conte, M. R.; Mardakheh, F. K.
10.1101/2024.09.20.614075 — biochemistry — Posted on 2025-04-15
2847 Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs
Cevrim, C.; Laplace-Builhe, B.; Sugawara, K.; Rusciano, M. L.; Labert, N.; Brocard, J.; Almazan, A.; Averof, M.
10.1101/2024.09.11.612529 — developmental biology — Posted on 2025-04-15
2848 How and when can environmental influences change cerebral cortex? An experimental training study of twins with birth weight differences
Walhovd, K. B.; Brathen, A. C. S.; Overbye, K.; Kransberg, J.; Sorensen, O.; Garrido, P. F.; Amlien, I. K.; Alatrorre-Warren, J.-L.; Mowinckel, A. M.; Falch, E. S.; Slivka, M.; Czajkowski, N. O.; Wang, Y.; Due-Tonnessen, P.; Harris, J. R.; Vidal-Pineiro, D.; Fjell, A.; Sneve, M. H.
10.1101/2025.03.06.641380 — neuroscience — Posted on 2025-04-15
2849 Beyond beta rhythms: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study
Gerster, M.; Waterstraat, G.; Binns, T. S.; Darcy, N.; Wiest, C.; Koehler, R. M.; Vanhoecke, J.; West, T. O.; Sure, M.; Todorov, D.; Radzinski, L.; Habets, J. G.; Busch, J. L.; Feldmann, L.; Krause, P.; Faust, K.; Schneider, G.-H.; Ashkan, K.; Pereira, E.; Akram, H.; Zrinzo, L.; Blankertz, B.; Villringer, A.; Tan, H.; Hirschmann, J.; Kuehn, A. A.; Florin, E.; Schnitzler, A.; Oswal, A.; Litvak, V.; Neumann, W.-J.; Curio, G.; Nikulin, V.
10.1101/2025.03.11.642600 — neuroscience — Posted on 2025-04-15
2852 Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control
Perez, M. J.; Colombo, R. B.; Real, S. M.; Branham, M. T.; Laurito, S. R.; Moraes, C. T.; Mayorga, L.
10.1101/2024.12.30.630791 — genomics — Posted on 2025-04-15
2853 Mixed evidence for species diversity affecting ecological forecasts in constant versus declining light
Limberger, R.; Daugaard, U.; Choffat, Y.; Gupta, A.; Jelic, M.; Jyrkinen, S.; Krug, R. M.; Nohl, S.; Pennekamp, F.; van Moorsel, S. J.; Zheng, X.; Zuppinger-Dingley, D.; Petchey, O. L.
10.1101/2024.04.30.591860 — ecology — Posted on 2025-04-15
2855 Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade
Snyder, A. J.; Shasha, C.; Ho, T.; Garrison, S.; Wilhelm, A. R.; Kluesner, M. G.; Ortiz, S.; Nutt, W. S.; Bingham, E.; Bhise, S. S.; Fan, E.; Zepeda, V.; Sarvothama, M.; Wang, X.; Potluri, S.; Long, A.; Elz, A.; Furlan, S.; Newell, E. W.; Srivastava, S.
10.1101/2025.04.10.648245 — immunology — Posted on 2025-04-15
2856 Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice
Byron, N.; McAlinden, N.; Pisano, F.; Pisanello, M.; Ferreira, J.; Montinaro, C.; Mathieson, K.; De Vittorio, M.; Pisanello, F.; Sakata, S.
10.1101/2025.04.08.647900 — neuroscience — Posted on 2025-04-15
2860 Fractionated radiation alters the extracellular matrix produced by muscle-invasive bladder cancer cells
Guerrero Quiles, C.; Fahy, S.; Bartak, M.; Gonzalez A., J.; Powell, E.; Reed, R.; Reeves, K.; Baker, A.; Hoskin, P.; James, N. D.; Hall, E.; Huddart, R. A.; Porta, N.; West, C.; Biolatti, V.; Choudhury, A.
10.1101/2025.04.08.647735 — cancer biology — Posted on 2025-04-15
2864 Spatial Transcriptomics Using Archived Formalin-Fixed Paraffin-Embedded Core Needle Biopsy Tissues Revealed Unique Transcriptomic Signatures in Kidney Transplant Rejections
Wongworawat, Y. C.; Nepal, C.; Duhon, M.; Chen, W.; Nguyen, M.-T.; Godzik, A.; Qiu, X.; Li, V. W.; Yu, G.; Villicana, R.; Zuppan, C.; De Vera, M.; Haas, M.; Wang, C.
10.1101/2025.04.08.647600 — immunology — Posted on 2025-04-15
2865 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy
Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — systems biology — Posted on 2025-04-15
2866 Hepatic isomiR landscaping reveals new biological insights into metabolic dysfunction in steatotic liver disease
Brion, C.; Hoang, S. A.; Wang, G.; Mirshahi, F.; Ang, J.; Long, M. R.; Zhu, Z.; Sakhamuri, B.; Srour, M. A.; Siddiqui, M. S.; Asgharpour, A.; Hayes, D. J.; Foster, N. C.; Salzman, D. W.; Sanyal, A. J.
10.1101/2025.04.08.647685 — bioinformatics — Posted on 2025-04-15
2869 Circuit Mining in Transcriptomics Data
Peherstorfer, T.; Ulonska, S.; Burger, B.; Lucato, S.; Al-Hamdan, B.; Kleinlehner, M.; Andlauer, T. F. M.; Bühler, K.
10.1101/2025.04.09.647750 — bioinformatics — Posted on 2025-04-15
2870 Complex genetic determinism of male-fertility restoration in the gynodioecious snail Physa acuta
Skarlou, E.; Laugier, F.; Bethune, K.; Chenin, T.; Donnay, J.-M.; Froissard, C.; David, P.
10.1101/2024.08.08.607164 — evolutionary biology — Posted on 2025-04-15
2871 Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
Bicka, M.; Ghanaeian, A.; Black, C.; Joachimiak, E.; Osinka, A.; Majhi, S.; Konopka, A.; Bulska, E.; Bui, K. H.; Wloga, D.
10.1101/2023.08.11.551218 — cell biology — Posted on 2025-04-15
2872 Sulfoquinovose is exclusively metabolized by the gut microbiota and degraded differently in mice and humans
Krasenbrink, J.; Hanson, B. T.; Weiss, A. S.; Borusak, S.; Tanabe, T. S.; Lang, M.; Aichinger, G.; Hausmann, B.; Berry, D.; Richter, A.; Marko, D.; Mussmann, M.; Schleheck, D.; Stecher, B.; Loy, A.
10.1101/2025.01.22.634256 — microbiology — Posted on 2025-04-15
2873 Effects of Combination Therapy of a CDK4/6 and MEK Inhibitor in Diffuse Midline Glioma Preclinical Models
Tomita, Y.; Link, G.; Ge, Y.; Gold, E. R. H.; Cardona, H. J.; Romero, M.; Gadd, S.; Watanabe, J.; Uchida, E.; Hashizume, R.; Takata, N.; Pinero, G.; Hambardzumyan, D.; Spasojevic, I.; Hu, G.; Hennika, T.; Brat, D. J.; Green, A.; Becher, O. J.
10.1101/2025.04.08.647742 — cancer biology — Posted on 2025-04-15
2874 Harnessing AlphaFold to reveal hERG channel conformational state secrets
Ngo, K.; Yang, P.-C.; Yarov-Yarovoy, V.; Clancy, C. E.; Vorobyov, I.
10.1101/2024.01.27.577468 — biophysics — Posted on 2025-04-15
2878 Genome organization by SATB1 binding to base-unpairing regions (BURs) provides scaffold for SATB1-regulated gene expression
Kohwi, Y.; Wong, X.; Grange, M.; Sexton, T.; Richards, H. W.; Kitagawa, Y.; Sakaguchi, S.; Liang, Y.-C.; Chuong, C.-M.; Botchkarev, V.; Taniuchi, I.; Reddy, K. L.; Kohwi-Shigematsu, T.
10.1101/2021.12.19.473323 — genomics — Posted on 2025-04-15
2879 Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink
Li, M.; Li, Y.; Mao, S.; Zhang, Z.; Chen, C.; Nie, X.; Liu, X.; Wang, H.; Liu, X.; Zhang, W.; Lin, Q.; Zhuang, G.-C.; Sun, J.
10.1101/2024.02.25.581922 — microbiology — Posted on 2025-04-15
2880 SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo
Jakhar, K.; Sonar, S.; Singh, G.; Asuru, T. R.; Joshi, G.; Beniwal, N.; Sarkar, T.; Tiwari, M.; Kaur, J.; Rathore, D. K.; Lal, B.; Kumar, S.; Srivastav, P.; Kumar, S.; Phagna, V.; Mithina, S.; Kumar, L.; Gupta, V.; Kshetrapal, P.; Singh, S.; Wadhwa, N.; Thiruvengadam, R.; Raghavan, S.; Gosain, M.; Shrivastava, T.; Bhattacharyya, S.; Asthana, S.; Guchhait, P.; Mani, S.
10.1101/2023.10.09.557914 — immunology — Posted on 2025-04-15
2881 A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration
Goettert, S.; Thiele-Orberg, E.; Fan, K.; Heinrich, P.; Matthe, D.; Khalid, O.; Klostermeier, L.; Suriano, C.; Strieder, N.; Gebhard, C.; Vonbrunn, E.; Mamilos, A.; Hirsch, D.; Meedt, E.; Kleigrewe, K.; Hiergeist, A.; Glaesner, J.; Ghimire, S.; Joachim, L.; Voll, F.; Neuhaus, K.; Perl, M.; Pielmeier, F.; Janssen, K.-P.; Ruland, J.; Kreutz, M.; Weber, D.; Schmidl, C.; Koehler, N.; Tschurtschenthaler, M.; Hoffmann, P.; Edinger, M.; Wolff, D.; Bassermann, F.; Rehli, M.; Haller, D.; Evert, M.; Hildner, K.; Buettner-Herold, M.; Herr, W.; Gessner, A.; Heidegger, S.; Holler, E.; Poeck, H.
10.1101/2025.04.08.647747 — immunology — Posted on 2025-04-15
2883 Accurate and rapid determination of metabolic flux by deep learning of isotope patterns
Law, R. C.; Pande, K.; O'Keeffe, S.; Nurwono, G.; Ki, R.; Lai, P.-K.; Park, J. O.
10.1101/2023.11.06.565907 — systems biology — Posted on 2025-04-15
2884 Exploring use of a protein cage system for producing bioactive peptides in Escherichia coli
Harding, M. D.; Jackson, M. A.; Gilding, E. K.; Yap, K.; Craik, D. J.; Sainsbury, F.; Lawrence, N.
10.1101/2024.12.16.628579 — synthetic biology — Posted on 2025-04-15
2886 Direct high-throughput deconvolution of non-canonical bases via nanopore sequencing and bootstrapped learning
Perez, M.; Kimoto, M.; Rajakumar, P.; Suphavilai, C.; Peres da Silva, R.; Pen Tan, H.; Ting Xun Ong, N.; Nicholas, H.; Hirao, I.; Wei Leong, C.; Nagarajan, N.
10.1101/2024.12.02.625113 — synthetic biology — Posted on 2025-04-15
2889 Longitudinal dynamics of gut plasmidome and antibiotic resistance during antibiotic therapy: a case report
Jonsdottir, I.; Meaden, S.; Salminen, P.; Kallonen, T.; Ravantti, J.; Pajander, A.; Vanhatalo, S.; Jalasvuori, M.; Sundberg, L.-R.; Westra, E.; Van Houte, S.; Hakanen, A. J.; Penttinen, R.
10.1101/2025.04.12.648487 — microbiology — Posted on 2025-04-14
2890 Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry
Zhai, R.; Hu, Y.; Zheng, L.; Xiang, S.; Xie, C.; Peng, L.; Banaschewski, T.; Barker, G. J.; Bokde, A. L. W.; Bruehl, R.; Desrivieres, S.; Flor, H.; Garavan, H.; Gowland, P.; Grigis, A.; Heinz, A.; Lemaitre, H.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; Nees, F.; Orfanos, D. P.; Poustka, L.; Smolka, M. N.; Hohmann, S.; Holz, N.; Vaidya, N.; Whelan, R.; Zhang, Z.; Robinson, L.; Winterer, J.; King, S.; Zhang, Y.; Kebir, H.; Schmidt, U.; Sinclair, J.; Stringaris, A.; Schumann, G.; Bzdok, D.; Walter, H.; Rolls, E. T.; Sahakian, B.; Robbins, T. W.; Feng, J.; Gong, W.; Jia, T.; IMAGEN Consort
10.1101/2025.04.12.648506 — neuroscience — Posted on 2025-04-14
2891 TD2: finding protein coding regions in transcripts
Mao, A.; Ji, H. J.; Haas, B.; Salzberg, S.; Sommer, M. J.
10.1101/2025.04.13.648579 — genomics — Posted on 2025-04-14
2893 Single-Molecule Kinetic Exploration of Functional Substates in an Evolving Phosphotriesterase
Sakuma, M.; Mahato, D. R.; Feixas, F.; Jackson, C. J.; Nakata, E.; Osuna, S.; Tokuriki, N.
10.1101/2025.04.14.648755 — biochemistry — Posted on 2025-04-14
2894 Old age variably impacts chimpanzee engagement and efficiency in stone tool use
Howard-Spink, E.; Matsuzawa, T.; Carvalho, S.; Hobaiter, C.; Almeida-Warren, K.; Gruber, T.; Biro, D.
10.1101/2024.11.25.625128 — animal behavior and cognition — Posted on 2025-04-14
2895 Seasonal transcriptional profiling of malaria parasites using a new single-cell atlas of a Malian Plasmodium falciparum isolate
Votborg-Novel, L.; Kampmann, M.; Carrasquilla, M.; Angeli, G.; Ntalla, C.; Cisse, H.; Sogoba, Y.; Guerra, G. M.; Doumbo, S. N.; Doumtabe, D.; Bandermann, S.; Cuesta-Valero, Y.; Kayentao, K.; Mashreghi, M.-F.; Niangaly, M.; Crompton, P. D.; Otto, T. D.; Traore, B.; Portugal, S.
10.1101/2025.04.14.648697 — molecular biology — Posted on 2025-04-14
2896 Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis
Lin, Z.; Wang, W.; Liu, D.; Liu, Q.; Wang, C.; Xu, Z.; Wu, Z.; Zhou, X.; Zhang, X.; Huang, Y.; Zhao, Q.; Yang, J.
10.1101/2024.04.20.590432 — microbiology — Posted on 2025-04-14
2898 Emerging Resistance to Novel -βLactam β-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants
Hamza, M.; Traglia, G. M. M.; Maccari, L.; Gomez, S.; Sanz, M. B.; Akhtar, U.; Mezcord, V.; Escalante, J.; Corso, A.; Rodriguez, C.; Bethel, C. R.; Rao, G. G.; Tolmasky, M. E.; Paterson, D.; Bonomo, R. A.; Pasteran, F.; Ramirez, M. S.
10.1101/2025.04.14.648765 — microbiology — Posted on 2025-04-14
2899 Phenotypic and omics analyses of the Sordariomycetes Marquandomyces marquandii and Albophoma yamanashiensis isolated from estuarine sediments.
Agirrezabala, Z.; Otamendi, A.; Liebana, R.; Azkargorta, M.; Perez-Cruz, C.; Duenas, M. T.; Ostra, M.; Lopez, R.; Grigoriev, I. V.; Alonso-Saez, L.; Elortza, F.; Lanzen, A.; Haridas, S.; Etxebeste, O.
10.1101/2023.07.26.550687 — microbiology — Posted on 2025-04-14
2900 Peak alpha frequency is not significantly altered by five days of experimental pain and repetitive transcranial stimulation of the left dorsolateral prefrontal cortex
Millard, S. K.; Chiang, A. K.; Chowdhury, N.; Chang, W.-J.; Furman, A. J.; De Martino, E.; Graven-Nielsen, T.; Schabrun, S. M.; Seminowicz, D. A.
10.1101/2024.06.14.599003 — neuroscience — Posted on 2025-04-14
2901 Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision
Rahmati, M.; Moujaes, F.; Suljic, N. P.; Ji, J. L.; Berkovitch, L.; Lee, K.; Fonteneau, C.; Schleifer, C. H.; Adkinson, B. D.; Savic, A.; Santamauro, N.; Tamayo, Z.; Diehl, C.; Kolobaric, A.; Flynn, M.; Camarro, T.; Curtis, C. E.; Repovs, G.; Fineberg, S. K.; Morgan, P. T.; Preller, K. H.; Krystal, J. H.; Murray, J. D.; Cho, Y. T.; Anticevic, A.
10.1101/2025.02.10.637233 — neuroscience — Posted on 2025-04-14
2904 Vowel-like patterns modulate auditory P100m response but not its association with language abilities in children with ASD
Fadeev, K. A.; Romero Reyes, I. V.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Rytikova, A. M.; Novikov, A. Y.; Stroganova, T. A.; Orekhova, E. V.
10.1101/2025.04.10.648101 — neuroscience — Posted on 2025-04-14
2906 The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus
Fang, W.; Zai, X.; Chen, J.; Abubakar, Y. S.; Wu, Q.; Fang, Z.; Huang, X.; Gan, X.; Ebbole, D. J.; Wang, Z.; Zheng, W.
10.1101/2024.07.11.603048 — pathology — Posted on 2025-04-14
2907 IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models
Singh, K.; Hotchkiss, K. M.; Cook, S. L.; Noldner, P.; Zhou, Y.; Moelker, E. M.; Railton, C. O.; Blandford, E. E.; Puviindran, B. J.; Wallace, S. E.; Norberg, P. K.; Archer, G. E.; Shaz, B. H.; Ayasoufi, K.; Sampson, J. H.; Khasraw, M.; Fecci, P. E.
10.1101/2024.04.01.587634 — cancer biology — Posted on 2025-04-14
2908 CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization
Drouillard, D.; Halyko, M.; Cinquegrani, E.; Poimenidou, M.; Emosivbe, M.; McAllister, D.; Peterson, F. C.; Marchese, A.; Dwinell, M. B.
10.1101/2024.08.26.609725 — cancer biology — Posted on 2025-04-14
2911 Quantifying and modeling loss of steroid hormones in PDMS-based devices
Hermann, N. G.; Ficek, R. A.; Markov, D. A.; McCawley, L. J.; Hutson, M. S.
10.1101/2025.04.08.647867 — bioengineering — Posted on 2025-04-14
2912 Identification of the trail-following pheromone receptor in termites
Diallo, S.; Kasparova, K.; Sulc, J.; Johny, J.; Krivanek, J.; Nebesarova, J.; Sillam-Dusses, D.; Kyjakova, P.; Vondrasek, J.; Machara, A.; Luksan, O.; Grosse-Wilde, E.; Hanus, R.
10.1101/2024.07.24.605012 — animal behavior and cognition — Posted on 2025-04-14
2914 A systemically delivered AAV-CFTR gene therapy for cystic fibrosis
Plasschaert, L. W.; Stutz, C.; Otarola, E.; Ruggeri, L.; Misiolek, R. V.; Nuccio, A.; Shang, J.; Choo-Wing, R.; Taddase, B.; Decock, A.; Quigley, C.; Kubek-Luck, K.; Warnant, I.; Aibo, D. I.; Magnifico, M.; Buchs, M.; Tan, G.; Ashley, L.; Wang, H.-K.; Watson, R.; Lin, A.
10.1101/2025.03.20.642115 — genetics — Posted on 2025-04-14
2921 How learning to read visual Braille co-opts the reading brain
Cerpelloni, F.; Van Audenhaege, A.; Matuszewski, J.; Gau, R.; Battal, C.; Falagiarda, F.; Op de Beeck, H.; Collignon, O.
10.1101/2024.05.08.593104 — neuroscience — Posted on 2025-04-14
2922 Application of Whole Proteome Thermal Shift Assays to Define PERK-dependent Changes in Protein Homeostasis during the Unfolded Protein Response
McCracken, N. A.; Justice, S. A. P.; Smith-Kinnaman, W. R.; Wijeratne, H. S.; Runnebohm, A. M.; Pelletier, S.; Doud, E. H.; Wek, R. C.; Mosley, A. L.
10.1101/2025.04.08.647882 — systems biology — Posted on 2025-04-14
2927 Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
Chen, Y.-C.; Takada, M.; Nagornyuk, A.; Yu, M.; Yamada, H.; Nagashima, T.; Ohtsuka, M.; DeLuca, J. G.; Markus, S. M.; Takaku, M.; Suzuki, A.
10.1101/2024.11.04.621816 — cancer biology — Posted on 2025-04-14
2928 Non-equilibrium remodelling of collagen-IV networks in silico
Meadowcroft, B.; Sorichetti, V.; Ratajczyk, E.; Khalilgharibi, N.; Mao, Y.; Palaia, I.; Saric, A.
10.1101/2024.10.10.617412 — biophysics — Posted on 2025-04-14
2933 A structural basis for chaperone repression of stress signalling from the endoplasmic reticulum
Neidhardt, L.; Tung, J.; Kuchersky, M.; Milczarek, J.; Kargas, V.; Stott, K.; Rosenzweig, R. S.; Ron, D.; Yan, Y.
10.1101/2025.04.14.648677 — biochemistry — Posted on 2025-04-14
2934 Designed NGF mimetics with reduced nociceptive signatures in neurons
Schlichthaerle, T.; Yang, A.; Detraux, D.; Johnson, D. E.; Peach, C. J.; Edman, N. I.; Sniezek, C.; Williams, C. A.; Arora, S.; Katiyar, N.; Chen, I.; Etemadi, A.; Favor, A.; Lee, D.; Kubo, C.; Coventry, B.; Huang, B.; Gerben, S.; Ennist, N. M.; Milles, L.; Sankaran, B.; Kang, A.; Nguyen, H.; Bera, A. K.; Negahdari, B.; Hamazaki, N.; Schweppe, D. K.; Stewart, L.; Young, J. E.; Bunnett, N. W.; Ruohola-Baker, H.; Mathieu, J.; Pattwell, S.; Garcia, K. C.; Baker, D.
10.1101/2025.04.14.648806 — biochemistry — Posted on 2025-04-14
2937 A Model of Ethanol Self-Administration in Head-Fixed Mice
Ward, A. L.; Winston, K. T.; Buchmaier, S. A.; Cooper, C. J.; Clarke, R. E.; Martino, M. R.; Vollmer, K. M.; Paniccia, J.; Bell, M. S.; Doncheck, E. M.; Grant, R. I.; Boquiren, J.; Baek, J.; Manusky, L. M.; Westphal, A. M.; Green, L. M.; Pagoota, B. E.; Otis, J. M.; Rinker, J. A.
10.1101/2024.02.17.580838 — animal behavior and cognition — Posted on 2025-04-14
2938 Sex differentiation, divergence, and introgression in the leishmaniasis vector Lutzomyia longipalpis
Stuckert, A. M.; Turissini, D.; DAgostino, E. R.; Peede, D.; Parvathaneni, M.; Rader, J. A.; Muskus, C.; Bejarano, E.; Wang, J. R.; Vivero, R.; Matute, D. R.
10.1101/2025.04.08.647763 — genomics — Posted on 2025-04-14
2939 Precision and Accuracy in Quantitative Measurement of Gene Expression from Single-Cell/Nuclei RNA Sequencing Data
Dai, R.; Zhang, M.; Chu, T.; Kopp, R.; Zhang, C.; Liu, K.; Wang, Y.; Wang, X.; Chen, C.; Liu, C.
10.1101/2024.04.12.589216 — genomics — Posted on 2025-04-14
2940 Research on Crop Phenotype Prediction Methods Based on SNP-context and Whole-genome Features Embedding
Huan, L.; peng, C. Y.; Zhen, C.; Ting, W.; Chao, W.; bo, B. W.; Juan, L.; Mo, W.; Li, C.; ming, W. J.
10.1101/2025.04.08.647762 — genetics — Posted on 2025-04-14
2942 An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites
Blauwkamp, J. A.; Rajaram, K.; Staggers, S. R.; Harrigan, O.; Doud, E. H.; Prigge, S. T.; Sun, S. Y.; Absalon, S.
10.1101/2025.04.12.648511 — cell biology — Posted on 2025-04-14
2943 The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation
Yang, X.; He, F.; Porter, D. F.; Garbett, K.; Meyers, R. M.; Reynolds, D. L.; Duy, L. H. B.; Hong, A.; Ducoli, L.; Siprashvili, Z.; Lopez-Pajares, V.; Mondal, S.; Ko, L.; Jing, Y.; Tao, S.; Singal, B.; Sando, R.; Skiniotis, G.; Khavari, P. A.
10.1101/2025.02.19.639154 — cell biology — Posted on 2025-04-14
2947 Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria..
Larotonda, L. I.; Ojeda, E.; Bordignon, M. B.; Fulgenzi, F. R.; Comerci, D. J.; Val, M.-E.; Llorente, B. E.; Mazel, D.; Soler-Bistue, A.
10.1101/2025.04.14.645983 — microbiology — Posted on 2025-04-14
2948 Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach
Agarwal, N.; Gogoi, H.; Eeba, E.; Augustin, L.; Khan, M. Y.; Kumar, Y.; Bhowmick, S. K.; Dey, B.
10.1101/2025.04.14.648691 — microbiology — Posted on 2025-04-14
2949 Vector Competence of Temperate and Tropical Mosquito Species for Babanki virus
Ban, M.; Geolier, V.; Ferquel, E.; Faye, M.; Diagne, M. M.; Ndiaye, E. H.; Fall, G.; Diallo, M.; Lavillette, D.; Choumet, V.
10.1101/2025.04.14.648682 — microbiology — Posted on 2025-04-14
2952 Echoes of 1816: Microbial Footprints in Heritage Artifacts From Argentina's Museum of Independence
Alonso-Reyes, D. G.; Galvan, F. S.; Alvarado, N.; D'Arpino, C.; Martinez, L. J.; Esquivel, H. J.; Gallardo, C. A.; Silva Manco, M. J.; Albarracin, V. H.
10.1101/2025.03.28.645971 — microbiology — Posted on 2025-04-14
2953 Comparative susceptibility of Old World and New World bat cell lines to Zika virus: Insights into viral replication and inflammatory responses
Brown, A. J.; Fagre, A. C.; Gilson, J.; Horton, J.; Rivero, R.; Karimi, M.; Speranza, E.; Letko, M. C.; Seifert, S. N.
10.1101/2025.03.27.645813 — microbiology — Posted on 2025-04-14
2954 De novo design and structure of a peptide-centric TCR mimic binding module
Householder, K. D.; Xiang, X.; Jude, K. M.; Deng, A.; Obenaus, M.; Wilson, S. C.; Chen, X.; Wang, N.; Garcia, K. C.
10.1101/2024.12.16.628822 — immunology — Posted on 2025-04-14
2956 Efficient genetic code expansion tools enable in vivo study of lysine acetylation in non-model bacteria
Van Fossen, E. M.; Stephenson, M.; Frank, A.; Akella, S.; Wooldridge, R.; Wilson, A.; You, Y.; Nakayasu, E.; Egbert, R.; Elmore, J. R.
10.1101/2025.04.14.648644 — synthetic biology — Posted on 2025-04-14
2957 High radiosensitivity in the conifer Norway spruce (Picea abies) due to lesscomprehensive mobilisation of protection and repair responses compared to the radiotolerant Arabidopsis thaliana
Bhattacharjee, P.; Blagojevic, D.; Lee, Y.; Gillard, G. B.; Gronvold, L.; Hvidsten, T. R.; Sandve, S. R.; Lind, O. C.; Salbu, B.; Brede, D. A.; Olsen, J. E.
10.1101/2023.11.20.562501 — plant biology — Posted on 2025-04-14
2958 Customizable host and viral transcript enrichment using CRISPR-Cas9 long-read sequencing for isoform discovery and validation
Nguyen, A. N. T.; Zhang, J.; Zhang, S.; Pitt, M. E.; Ganesamoorthy, D.; Fritzlar, S.; Chang, J. J. Y.; Londrigan, S.; Coin, L. J. M.
10.1101/2025.04.11.648353 — genomics — Posted on 2025-04-14
2959 Arsenic Toxicity in the Drosophila Brain at Single Cell Resolution
Chaturvedi, A.; Shankar, V.; Simkhada, B.; Lyman, R. A.; Freymuth, P.; Howansky, E.; Collins, K. M.; Mackay, T. F. C.; Anholt, R. R. H. R. H.
10.1101/2025.04.09.647950 — genetics — Posted on 2025-04-14
2960 Repressive S-adenosylmethionine biosynthesis status inhibits transcription of HeT-A retrotransposon in the germline of Drosophila.
Hayashi, Y.; Hino, S.; Sato, T.; Kashio, S.; Saito, K.; Sato, B.; Kawano, N.; Saito, D.; Miura, M.; Suyama, M.; Nakao, M.; Kobayashi, S.
10.1101/2025.04.12.648310 — developmental biology — Posted on 2025-04-14
2961 CO2 sensitive connexin channel synapses in the VTA release 5HT to regulate dopaminergic neurons
Huang, L.; Butler, J.; Lovatt, A.; Bhandare, A.; Pelletier, J.; Hill, E.; Dale, N.; wall, M. J.
10.1101/2025.04.14.648741 — neuroscience — Posted on 2025-04-14
2962 Modeling AP2M1 Developmental and Epileptic Encephalopathy in Drosophila
Karge, R. A.; Fischer, F. P.; Schüth, H.; Wechner, A.; Peter, S.; Kilo, L. A.; Dichter, M.; Voigt, A.; Tavosanis, G.; van Loo, K. M. J.; Koch, H.; Weber, Y.; Wolking, S.
10.1101/2025.04.11.648441 — neuroscience — Posted on 2025-04-14
2963 Glia phagocytose neuronal sphingolipids to infiltrate developing synapses
Theisen, E. K.; Rivas-Serna, I. M.; Lee, R. J.; Jay, T. R.; Kunduri, G.; Nguyen, T. T.; Freeman, M. R.; Mazurak, V.; Clandinin, M. T.; Clandinin, T. R.; Vaughen, J. P.
10.1101/2025.04.14.648777 — neuroscience — Posted on 2025-04-14
2964 Unfolding admixed ancestry and genomic diversity in zoo giraffes
Fraser, M. F.; Heller, R.; Bertola, L. D.; Hvilsom, C.; Balboa, R. F.; Liu, X.; Bruniche-Olsen, A.
10.1101/2025.03.31.645993 — evolutionary biology — Posted on 2025-04-14
2965 Nucleus softens during herpesvirus infection
Tervonen, A.; Leclerc, S.; Ruokolainen, V.; Tieu, K.; Lyonnais, S.; Niskanen, H.; Chen, J.-H.; Gupta, A.; Kaikkonen, M. U.; Larabell, C. A.; Muriaux, D.; Mattola, S.; Conway, D. E.; Ihalainen, T. O.; Aho, V.; Vihinen-Ranta, M.
10.1101/2025.01.03.631188 — cell biology — Posted on 2025-04-14
2966 Enantiomeric Hydrogel-Manipulated Mechanotransduction Triggers Neurogenesis and Immunomodulation for Spinal Cord Repair
Li, Y.; Wang, Y.; Fang, X.; Zhang, H.; Li, R.; Cai, R.; Li, X.; Yang, Z.; Li, X.; Huang, Z.; Yin, G.; Wang, A.; Ao, Q.
10.1101/2025.01.10.632462 — neuroscience — Posted on 2025-04-14
2967 Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response
Cenzano, I.; Cocera, M.; Larrayoz, M.; Campos-Dopazo, L.; Sanz, S.; Bantan, A.; Vilas, A.; San-Martin, P.; Aguirre-Ruiz, P.; Alignani, D.; Lopez, A.; Sancho Gonzalez, I.; Ruiz, J.; Ripalda-Cemborain, P.; Abengozar-Muela, M.; Muinos-Lopez, E.; Lagani, V.; Tegner, J.; Hernaez, M.; Agirre, X.; Ebert, B.; Paiva, B.; Rodriguez-Otero, P.; Tamariz-Amador, L.-E.; San-Miguel, J.; Saez, B.; Martinez-Climent, J. A.; Calvo, I. A.; Gomez-Cabrero, D.; Prosper, F.
10.1101/2024.04.24.589777 — cancer biology — Posted on 2025-04-14
2968 State-specific Peptide Design Targeting G Protein-coupled Receptors
Xue, Y.; Wang, H.; Li, J.; Hu, J.; Chen, Z.; Zheng, Z.; Liu, L.; Zhu, K.; He, J.; Gong, H.; Li, X.; Zhang, X.; Fang, X.
10.1101/2024.11.27.625792 — bioinformatics — Posted on 2025-04-14
2971 The Hitchdock Domain in Kinesin-2 Tail Enables Adaptor Assembly and Cargo Binding
Jiang, X.; Danev, R.; Niu, B.; Ohtsuki, S.; Yanagisawa, H.; Hirokawa, N.; Kikkawa, M.
10.1101/2025.03.21.644525 — cell biology — Posted on 2025-04-14
2972 Degradation of resistant α-1,4-glucan by vaginal Gardnerella species is associated with bacterial vaginosis
Hertzberger, R.; Morselli, S.; Botschuijver, S.; Himschoot, L.; Bruisten, S.; Steenbergen, L.; Lewis, W.; Cools, P.; Kort, R.
10.1101/2023.01.28.526025 — microbiology — Posted on 2025-04-14
2973 Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts
Regimbeau, A.; Tian, F.; Smith, G.; Riddell, J.; Andreani, C.; Bordron, P.; Budinich, M.; Howard-Varona, C.; Larhlimi, A.; Ser-Giacomi, E.; Trottier, C.; Guidi, L.; Hallam, S. J.; Iudicone, D.; Karsenti, E.; Maass, A.; Sullivan, M. B.; Eveillard, D.
10.1101/2025.02.13.638167 — systems biology — Posted on 2025-04-14
2974 The auxin gatekeepers: Evolution and diversification of the YUCCA family
Vijayanathan, M.; Faryad, A.; Abeywickrama, T. D.; Christensen, J. M.; Neilson, E. H.
10.1101/2025.04.11.648386 — plant biology — Posted on 2025-04-14
2975 Identification of MARVELlous Protein Markers for Phytophthora infestans Extracellular Vesicles
Breen, S.; McLellan, H.; Wang, W.; Wang, S.; Welsh, L.; Pham, J.; Whisson (SW), s.; Boevink, P.; Birch, P. R.
10.1101/2025.04.11.648357 — plant biology — Posted on 2025-04-14
2976 Arsenic-sensing domain controls ACR3 transporter trafficking and function in Marchantia polymorpha
Mizio, K.; Bonter, I.; Zbieralski, K.; Dolzblasz, A.; Tomaszewska, P.; Staszewski, J.; Wawrzycka, D.; Reymer, A.; Bialek, W.; Kriechbaumer, V.; Haseloff, J.; Wysocki, R.; Maciaszczyk-Dziubinska, E.
10.1101/2025.04.13.648538 — plant biology — Posted on 2025-04-14
2977 Comparative transcriptomics uncovers plant and fungal genetic determinants of mycorrhizal compatibility
Marques-Galvez, J. E.; de Freitas Pereira, M.; Nehls, U.; Ruytinx, J.; Barry, K.; Peter, M.; Martin, F.; Grigoriev, I. V.; Veneault-Fourrey, C.; Kohler, A.
10.1101/2025.04.11.648352 — plant biology — Posted on 2025-04-14
2978 RNA sequence analysis of somatic mutations in aging and Parkinson's Disease
Sun, S.; Sproviero, D.; Payan-Gomez, C.; Hoeijmakers, J.; Maslov, A. Y.; Mastroberardino, P. G.; Vijg, J.
10.1101/2025.03.26.645360 — genetics — Posted on 2025-04-14
2983 Arabidopsis HYPERSENSITIVE INDUCED REACTION 2 affects plasma membrane receptor pathways and organization
Weber, H.; Ehinger, A.; Kolb, D.; Fallahzadeh-Mamaghani, V.; Halter, T.; Franz-Wachtel, M.; zur Oven-Krockhaus, S.; Gronnier, J.; Zipfel, C.; Harter, K.; Kemmerling, B.
10.1101/2025.04.11.648320 — plant biology — Posted on 2025-04-14
2984 Recognition-dependent activation of the RRS1-R/RPS4 immune receptor complex
Ahn, H.-K.; Guo, G.; Sklenar, J.; Keh, S. P. Y.; Huh, S. U.; Hulin, M. T.; Burdett, H.; Sindalovskaya, M.; Choi, J.; Mukhi, N.; Zhao, H.; Knorr, L.; Banfield, M. J.; Menke, F.; Ma, W.; Jones, J. D.
10.1101/2025.04.11.646618 — plant biology — Posted on 2025-04-14
2986 PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour
Novelli, L.; Stoliker, D.; Barta, T.; Greaves, M. D.; Chopra, S.; Jackson, J.; Kwee, J.; Williams, M.; Razi, A.
10.1101/2025.04.11.643415 — neuroscience — Posted on 2025-04-14
2987 Dopaminergic drugs modulate fear extinction related processes in humans, but effects are mild
Doubliez, A.; Koster, K.; Muntefering, L.; Nio, E.; Diekmann, N.; Thieme, A.; Albayrak, B.; Nicksirat, S. A.; Erdlenbruch, F.; Batsikadze, G.; Ernst, T. M.; Cheng, S.; Merz, C. J.; Timmann, D.
10.1101/2025.04.11.648372 — neuroscience — Posted on 2025-04-14
2990 Microbes regulate glomerular filtration rate in health and chronic kidney disease in mice
Xu, J.; Verma, E.; Sanchez, J.; Gharaie, S.; Jeong, S.; Gooya, M.; Gupta, K.; Rabb, H.; Pluznick, J. L.
10.1101/2025.04.08.647647 — physiology — Posted on 2025-04-14
2991 Genetic control of the transcriptional response to active tuberculosis disease and treatment
O'Grady, J. F.; Leonard, A. S.; Li, H.; Fang, L.; Pausch, H.; Gormley, I. C.; Gordon, S. V.; MacHugh, D. E.
10.1101/2025.04.11.648383 — genetics — Posted on 2025-04-14
2992 ANKRD5: a key component of the axoneme required for spermmotility and male fertility
Yu, S.; Yin, G.; Jin, P.; Zhang, W.; Tian, Y.; Xu, X.; Shao, T.; Li, Y.; Sun, F.; Zhu, Y.; Wang, F.
10.1101/2024.12.03.626701 — developmental biology — Posted on 2025-04-14
2997 CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images
Matos-Romero, V.; Gomez-Becerril, J.; Forjaz, A.; Dequiedt, L.; Newton, T.; Joshi, S.; Shen, Y.; Hanna, E.; Nair, P. R.; Sivasubramanian, A.; Wang, J.; Lasse-Opsahl, E. L.; Bell, A. T. F.; Czum, J.; Steenbergen, C.; Dai, D.-F.; Wood, L. D.; Kagohara, L. T.; Fertig, E. J.; Pasca di Magliano, M.; Shatzel, J.; McCarty, O. J.; Lo, J. O.; Rosenberg, A.; Hruban, R. H.; Munoz-Barrutia, A.; Wirtz, D.; Kiemen, A. L.
10.1101/2025.04.11.648464 — bioinformatics — Posted on 2025-04-14
2998 Cytonuclear analysis of barley spike traits using a cytoplasm-aware population
Fridman, E.; Bodenheimer, S.; Bdolach, E.; Be'ery, A.; Tiwari, L. D.; Prez-Alfaro, R. S.; Yang, S.; Koenig, D.
10.1101/2025.04.08.647843 — genetics — Posted on 2025-04-14
3003 An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites
Blauwkamp, J. A.; Rajaram, K.; Staggers, S. R.; Harrigan, O.; Doud, E. H.; Prigge, S. T.; Sun, S. Y.; Absalon, S.
10.1101/2025.04.12.648511 — cell biology — Posted on 2025-04-14
3004 BRAPH 2: a flexible, open-source, reproducible, community-oriented, easy-to-use framework for network analyses in neurosciences
Chang, Y.-W.; Zufiria-Gerboles, B.; Gomez-Ruiz, P. E.; Canal-Garcia, A.; Zhao, H.; Mijalkov, M.; Braga Pereira, J.; Volpe, G.
10.1101/2025.04.11.648455 — neuroscience — Posted on 2025-04-14
3005 Neuronal networks in the dorsal hippocampus causally regulate rescue behavior in mice
dos Santos Correa, M.; Agafonova, A.; Braun, A.; Omprakash, C.; Tafani, E.; Lowitsch, M.; Marquardt, L.; Bauer, P.; Albrecht, A.; Mikulovic, S.
10.1101/2025.04.08.647754 — neuroscience — Posted on 2025-04-14
3012 A General Method for Detection and Segmentation of Terrestrial Arthropods in Images
Svenning, A.; Mougeot, G.; Alison, J.; Chevalier, D.; Molina, N. L. C.; Ong, S.-Q.; Bjerge, K.; Carrillo, J.; Hoeye, T. T.; Geissmann, Q.
10.1101/2025.04.08.647223 — ecology — Posted on 2025-04-14
3015 Failed Metabolic Adaptation to Stress Underlies Pathogenesis in a Heterozygous Genetic Disorder
Harmon, R.; McCarthy, E.; Krol, A.; Braun, J.; Shetti, A.; Godsel, L.; Ren, Z.; Perez-White, B.; Weinberg, S.; Simpson, C. L.; Dahl, R.; Goyal, Y.; Prakriya, M.; Cohen-Barak, E.; Dodiuk-Gad, R.; Paller, A. S.; Green, K. J.
10.1101/2025.04.13.648535 — cell biology — Posted on 2025-04-14
3021 Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites
Hoang, O. N.; Chan, C. E.; brenner, j. m.; Leza-Rincon, D.; Jaramillo, A. M.; Dolan, B.; Aziz, A. W.; Cardenas, R. A.; Cardenas, G. J.; Galvez, E. D.; Powell, R. T.; Vergara, L.; Karmouty-Quintana, H.; Magnusson, J. M.; Hansson, G. C.; Adachi, R.; Dickinson, J. D.; Evans, C. M.; Courson, J. A.; Burns, A. R.; Tuvim, M. J.; Dickey, B.
10.1101/2025.04.11.648270 — cell biology — Posted on 2025-04-14
3022 Altered laminin signaling destinates melanocyte reprogramming in vitiligo
Yang, F.; Yang, L.; Lai, S.; Yokota, M.; Kuroda, Y.; Yuki, T.; Takahashi, Y.; Sayo, T.; Namiki, T.; Goto, H.; Hiroyasu, S.; Sano, S.; Inoue, S.; Mizukami, Y.; Tsuruta, D.; Katayama, I.
10.1101/2025.04.11.648350 — cell biology — Posted on 2025-04-14
3023 Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study
Banerjee, P.; Kuhn, J.; Pal, D. S.; Deng, Y.; Banerjee, T.; Devreotes, P. N.; Iglesias, P. A.
10.1101/2025.04.12.648264 — cell biology — Posted on 2025-04-14
3025 A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus
Ash, A. M.; Baek, S. R.; Holder, P.; Vyleta, N. P.; Willman, M.; Nash, K. R.; Snyder, J. S.
10.1101/2025.04.08.647737 — neuroscience — Posted on 2025-04-14
3028 Continuous accelerated rock weathering by marine bacteria with enhanced siderophore production
Dalvie, N. C.; Jalihal, A. P.; Böhnke, J.-T.; Justman, Q. A.; Silver, P. A.; Springer, M.
10.1101/2025.04.08.647837 — systems biology — Posted on 2025-04-14
3030 Convergent Evolution of H4K16ac-mediated Dosage Compensation Shapes Sex-dependent Lifespan in a ZW Species
Zimmer, F.; Fox, A. M.; Pan, Q.; Ruehle, F.; Andersen, P.; Huylmans, A.-K.; Schwander, T.; Basilicata, M. F.; Keller Valsecchi, C. I.
10.1101/2025.04.10.648168 — evolutionary biology — Posted on 2025-04-14
3031 PANoptosis, a combination of inflammatory cell death mechanisms, induced 1 by Ophiobolin A in breast cancer cell lines
Ranganathan, S.; Ojo, T.; Subramanian, A.; Tobin, J.; Haberman, K.; Kornienko, A.; Boari, A.; Evidente, A.; Benton, M. L.; Romo, D.; Taube, J.
10.1101/2025.04.08.647841 — cancer biology — Posted on 2025-04-14
3034 The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters
Huang, X.; Kuang, Y.; Li, M.; Hong, M.; Xu, D.; Cheng, J.; Huang, T.; Sun, X.; Wang, W.; Zhou, Y.; Feng, X.; Chen, X.; Zhu, C.; Guang, S.
10.1101/2025.04.11.648483 — genetics — Posted on 2025-04-14
3037 Assessing the potential cardiovascular risk of microdosing the psychedelic LSD in mice
Effinger, D.; Schalk, S. S.; King, J. L.; Strong, J. R.; O'Connell, C. K.; Calderon, J. R.; McCorvy, J.; Thompson, S. M.
10.1101/2025.04.08.647757 — pharmacology and toxicology — Posted on 2025-04-14
3038 Ophiobolin A selectively alters mitochondria, metabolism and redox biology in breast cancer and mammary epithelial cells which have undergone epithelial to mesenchymal transition
Parker, H.; Tao, Y.; Tobin, J.; Haberman, K. L.; Davis, S.; York, E.; Martinez, A.; Matsumoto, N.; Aroujo, J.; Park, J.; Zechmann, B.; Kiapparettu, B. A.; Boari, A.; Sayes, C.; Evidente, A.; Kornienko, A.; Cravatt, B.; Romo, D.; Taube, J.
10.1101/2025.04.08.647828 — cancer biology — Posted on 2025-04-14
3039 Mucin anchoring of SARS-CoV-2 neutralizing nanobinders increases intranasal antiviral efficacy
Rocha Gomes, J.; Jacquelin, J.; Donchet, A.; Lejal, N.; Nevers, Q.; Konjkowski, B.; Le Poder, S.; Delmas, B.; MEUNIER, N.
10.1101/2025.04.10.648177 — microbiology — Posted on 2025-04-14
3040 Pleiotropic role of PAX cyclolipopeptides in the Xenorhabdus bacterium mutualistically associated with entomopathogenic nematodes
Claveyroles, N.; Lanois-Nouri, A.; El Fannassi, I.; Ogier, J.-c.; Pages, S.; Chouchou, A.; Cazals, G.; Valette, G.; Carre-Mlouka, A.; Givaudan, A.
10.1101/2025.04.11.648461 — microbiology — Posted on 2025-04-14
3041 Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection
Wang, A.; wang, j.; zhang, z.; yang, c.; deng, c.; Chen, G.; Li, C.; wang, q.; Dong, L.; Wang, C.
10.1101/2025.04.08.647814 — bioengineering — Posted on 2025-04-14
3045 LimbLab: Pipeline for 3D Analysis and Visualisation of Limb Bud Gene Expression
Avino Esteban, L.; Cardona-Blaya, H.; Musy, M.; Matyjaszkiewicz, A.; Sharpe, J.; Dalmasso, G.
10.1101/2025.04.08.647723 — bioinformatics — Posted on 2025-04-13
3046 SCARF: Single Cell ATAC-seq and RNA-seq Foundation model
Liu, G.; Zhao, Y.; Zhao, Y.; Wang, T.; Cai, Q.; Wang, X.; Wen, Z.; Lin, L.; Yang, G.; Chen, J.
10.1101/2025.04.07.647689 — bioinformatics — Posted on 2025-04-13
3047 Genome-wide association study in European beech (Fagus sylvatica L.) for drought stress traits
Tost, M.; Grigoriadou-Zormpa, O.; Wilhelmi, S.; Mueller, M.; Wildhagen, H.; Curtu, A. L.; Beissinger, T.; Gailing, O.
10.1101/2025.04.08.647712 — genetics — Posted on 2025-04-13
3048 Fitness Landscape Ruggedness Arises from Biophysical Complexity
Spence, M. A.; Sandhu, M.; Matthews, D. S.; Nichols, J.; Jackson, C. J.
10.1101/2025.04.12.648556 — evolutionary biology — Posted on 2025-04-13
3049 Single cell spatial proteomics maps human liver zonation patterns and their vulnerability to fibrosis
Weiss, C. A.; Brown, L. A.; Miranda, L.; Pellizzoni, P.; Ben-Moshe, S.; Steigerwald, S.; Remmert, K.; Hernandez, J.; Bogwardt, K.; Rosenberger, F. A.; Porat-Shliom, N.; Mann, M.
10.1101/2025.04.13.648568 — molecular biology — Posted on 2025-04-13
3051 Modular Engineering of Escherichia coli for Enhanced Nickel Uptake, Survival, Biomineralization, and Hydrogen-Supported Bioremediation
Shi, Y.; Ma, R.; Qi, L.; Tan, X.; Chen, L.; Wang, Y.; Huang, K.; Suo, Z.; Li, Y.; Chen, H.; Chen, Z.; Chen, X.; Li, W.; Zhen, K.
10.1101/2025.04.13.648562 — synthetic biology — Posted on 2025-04-13
3052 Protein Phosphatase 2A Subunit B55 Alpha is Required for Angiotensin Type 2 Receptor Elicited Natriuresis
Keller, S. R.; Gildea, J. J.; LI, J.; Kemp, B. A.; Conaway, M.; Brautigan, D. L.; Carey, R. M.; Howell, N.
10.1101/2025.04.07.647676 — physiology — Posted on 2025-04-13
3054 PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer
Arora, G. K.; Loughran, R. M.; Ly, K.; Galapate, C. M.; Llorente, A.; Anderson, T. R.; Scott, D. A.; Altman, Y.; Murad, R.; Commisso, C.; Emerling, B. M.
10.1101/2025.04.07.647654 — cancer biology — Posted on 2025-04-13
3056 PepPCBench is a Comprehensive Benchmark for Protein-Peptide Complex Structure Prediction with AlphaFold3
Zhai, S.; Zhao, H.; Wang, J.; Lin, S.; Liu, T.; Jiang, D.; Liu, H.; Kang, Y.; Yao, X.; Hou, T.
10.1101/2025.04.08.647699 — bioinformatics — Posted on 2025-04-13
3061 Symbiont virulence is a poor predictor of impacts on host population dynamics
Dziuba, M. K.; McIntire, K. M.; Davenport, E. S.; Corcoran, F. E.; Nelson, T.; McCreadie, P.; Manuel, R. T.; Baird, E.; Dos Santos, N. F.; Robbins, M.; Dismondy, E.; Monell, K. J.; Huerta, C.; Selter, L. C.; Deckelbaum, K.; Cortez, M. H.; Duffy, M. A.
10.1101/2025.04.10.648206 — ecology — Posted on 2025-04-13
3063 Spatial patterning of contractility by a mechanogen gradient underlies Drosophila gastrulation
Mundhe, G.; Dunsing-Eichenauer, V.; Philippe, J.-M.; Da Silva, E.; Collinet, C.; Lecuit, T.
10.1101/2025.04.11.648359 — developmental biology — Posted on 2025-04-13
3064 The PBAF chromatin remodeling complex contributes to metal homeostasis through Mtf1 regulation
Carulli, N.; Johnston, E.; Klein, D. C.; Verdejo-Torres, O.; Parikh, A.; Rivera, A.; Quinteros, M.; Pezacki, A. T.; Chang, C. J.; Hainer, S. J.; PADILLA-BENAVIDES, T.
10.1101/2025.04.12.648552 — molecular biology — Posted on 2025-04-13
3070 Phenotypic Antibiotic Susceptibility Testing at the limit of one bacterial cell
Ahmad, I.; Johansson, L.; Larsson, J.; Zikrin, S.; Knagge, P.; Fange, D.; Elf, J.
10.1101/2025.04.13.648565 — microbiology — Posted on 2025-04-13
3072 Tissue-specific improvements in CD4+ T cell responses after treatment for visceral leishmaniasis.
Engel, J. A.; Rivera, F.; Crawford, B.; Lee, H. J.; Na, J.; Chang, K.; Gartlan, K.; Bukali, L.; Frame, T.; Wang, Y.; Haque, A.; Engwerda, C.; Engwerda, C.
10.1101/2025.04.13.648617 — immunology — Posted on 2025-04-13
3073 Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis
Xiao, W.; Sawyer, A. J.; Mo, S.; Bai, X.; Yang, Q.; Gao, Y.; Fielder, T.; Zhang, Y.; Dai, Y.; Yang, Q.; Cai, Y.; Ding, G.; Deng, G.; Fu, L.; Quek, C.; Wilmott, J.; Palendira, U.; Britton, W.; Barber, D. L.; Ernst, J. D.; Patrick, E.; Feng, C.; Chen, X.
10.1101/2025.04.11.648467 — immunology — Posted on 2025-04-13
3074 Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma
Kraft, A.; Toenz, A.; Schlaepfer, F.; Ronner, M.; Orlowski, V.; Kirschner, M. B.; Felley-Bosco, E.; Bein, J.; Wild, P. J.; Boeva, V.; Opitz, I.; Meerang, M.
10.1101/2025.04.04.647264 — cancer biology — Posted on 2025-04-13
3075 Post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma
Guo, Y.; Finan, J. M.; Bartlett, A. Q.; Sivagnanam, S.; Blise, K. E.; Kirchberger, N.; Betre, K.; McCarthy, G. A.; Hawthorne, K.; Chen, C.; Grossberg, A.; Xia, Z.; Coussens, L. M.; Sears, R. C.; Brody, J. R.; Eil, R.
10.1101/2025.02.07.632847 — cancer biology — Posted on 2025-04-13
3076 Scratching in Style: 3D Printers as Plotters for Automated and Complex Wound Healing Assays
Köppe, H.; Richert, M. G.; Singer, D.; Köppe, J.; Köppe, M.; Tzvetkov, M.; Schroeder, H. W. S.; Bekeschus, S.; Bien-Möller, S.
10.1101/2024.09.19.613824 — bioengineering — Posted on 2025-04-13
3077 Comparison of Activities of Transcription Factor NF-κB from Two Jellyfish Models
Williams, L. M.; Wang, W.; Grigoryeva, A. V.; Navarro-Rosado, A.; Peart, J. A.; Calderon, A.; Gill, C. L.; Black, S.; Alsante, K. M.; Lackstrom, A. T.; Molecular Biology Laboratory, ; Weissbourd, B.; Wang, M.; DiRusso, C. J.; Cohen, L. B.; Wunderlich, Z.; Grone, B. P.; Gilmore, T. D.
10.1101/2025.01.21.634164 — molecular biology — Posted on 2025-04-13
3078 Induction of hemodynamic traveling waves by glial-related vasomotion in a rat model of neuroinflammation: implications for functional neuroimaging
Pereira, M.; Droguerre, M.; Valdebenito, M.; Vidal, L.; Marcy, G.; Benkeder, S.; Marchal, P.; Comte, J.-C.; Pascual, O.; Zimmer, L.; VIDAL, B.
10.1101/2024.12.13.628348 — neuroscience — Posted on 2025-04-13
3081 Relaxin signaling is critical for virgin female reproductive physiology in Drosophila
Volonte, Y.; Heredia, F.; Zanini, R.; Menezes, J.; Perez, M. S.; Gualdino, M.; Lage, L.; Cruz, L. d. S.; Casimiro, A. P.; Garelli, A.; Gontijo, A. M.
10.1101/2025.04.03.647069 — physiology — Posted on 2025-04-13
3083 PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape
Conley, E. A.; Lisowski, C. M.; Schaefer, K. G.; Davison, H. C.; Baguio, J.; Kosztin, I.; King, G.
10.1101/2024.05.06.592664 — biophysics — Posted on 2025-04-13
3090 Attuning to song duels facilitates song-matching in nightingales
Costalunga, G.; Carpena Sanchez, C.; Benichov, J. I.; Cross, C.; Clemens, J.; Vallentin, D.
10.1101/2025.04.12.648496 — neuroscience — Posted on 2025-04-13
3091 Nightingales imitate the duration of whistle syllables
Calderon Garcia, J. S.; Costalunga, G.; Vogels, T. P.; Vallentin, D.
10.1101/2025.04.12.648498 — animal behavior and cognition — Posted on 2025-04-13
3094 Identification of Injury-Response State Determinants in Glioblastoma Stem Cells
Molaei, F.; MacLeod, G.; Haider, S.; Tiffany, A.; Oteng, F. M.; Berman, J. M.; Skirzynska, A.; Shoichet, M. S.; Schramek, D.; Dirks, P. B.; Angers, S.
10.1101/2025.04.07.647626 — cancer biology — Posted on 2025-04-12
3096 HIV-1 Nef uses a conserved pocket to recruit the N-terminal cytoplasmic tail of Serinc3
Karimian Shamsabadi, M.; Stoneham, C.; De-leon, A.; Fares, T.; Guatelli, J.; Jia, X.
10.1101/2025.04.12.648528 — biochemistry — Posted on 2025-04-12
3097 The Response Regulator BqsR/CarR Controls Ferrous Iron (Fe2+) Acquisition in Pseudomonas aeruginosa
Paredes, A.; Singh, H.; Hull, M. T.; Greene, D.; Northrup, A. J.; Brown, J. B.; Chacon, K. N.; Patrauchan, M. A.; Smith, A. T.
10.1101/2025.04.12.648518 — biochemistry — Posted on 2025-04-12
3099 Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models
Zhu, B.; Van, R.; Wang, H.; Kuang, S.; Jia, Y.; Leon, E. C.; Yang, F.; Zhang, J.; Yang, J.; Hong, H.; Fleur Marie, L.; Yu, A.; Wang, J.; Tanzi, R. E.; Zhang, C. M.; Mao, X. M.; Shao, Y.; Ran, C.
10.1101/2025.04.12.648090 — biochemistry — Posted on 2025-04-12
3101 A DNA methylation-based clock for age estimates in the wood mouse (Apodemus sylvaticus)
Wolf, S. E.; Babayan, S. A.; Marioni, R. A.; Chandra, T.; Horvath, S.; Little, T. J.; Pedersen, A. B.
10.1101/2025.04.09.648041 — genomics — Posted on 2025-04-12
3102 First national survey of terrestrial biodiversity using airborne eDNA
Tournayre, O.; Littlefair, J. E.; Garrett, N. R.; Allerton, J. J.; Brown, A. S.; Cristescu, M. E.; Clare, E. L.
10.1101/2025.04.07.647580 — ecology — Posted on 2025-04-12
3103 Continental-scale relationships of fine root and soil carbon stocks hold in grasslands but not forests
Malhotra, A.; Moore, J. A. M.; Weintraub-Leff, S.; Georgiou, K.; Berhe, A. A.; Billings, S. A.; de Graaff, M.-A.; Fraterrigo, J. M.; Grandy, A. S.; Kyker-Snowman, E.; Lu, M.; Meier, C.; Pierson, D.; Tumber-Davila, S. J.; Lajtha, K.; Wieder, W. R.; Jackson, R. B.
10.1101/2025.04.07.647629 — ecology — Posted on 2025-04-12
3107 Plant host identity drives Andropogon gerardii rhizobiome assembly strategies under increasing abiotic stress
Vogt, B. M.; Kazarina, A.; Sytsma, J.; Adams, B.; Rodela, L.; Clouse, D.; Keller, R.; Thompson, D.; Winters, H.; Wagner, M.; Baer, S.; Jumpponen, A. M.; Johnson, L.; Lee, S. T. M.
10.1101/2025.04.12.648431 — microbiology — Posted on 2025-04-12
3110 The conserved SEN1 DNA/RNA helicase has multiple functions during yeast meiosis
Gaglione, R.; Caradonna, J.; MacQueen, A. J.; Luk, E.; Hollingsworth, N. M.
10.1101/2025.04.10.648140 — genetics — Posted on 2025-04-12
3111 TRPV1 Defends the Healthy Murine Cornea against Staphylococcus aureus Adhesion Independently of Sensory Nerve Firing
Flandrin, O.; Yang, Y.; Abboud, S.; Kumar, N. G.; Datta, A.; Bautista, D. M.; Evans, D. J.; Fleiszig, S. M. J.
10.1101/2025.04.12.648450 — microbiology — Posted on 2025-04-12
3113 Sp140L Is a Novel Herpesvirus Restriction Factor
Cable, J. M.; Wongwiwat, W.; Grabowski, J.; White, R. E.; Luftig, M. A.
10.1101/2024.12.13.628399 — microbiology — Posted on 2025-04-12
3117 A ketogenic diet mitigates hippocampal astrogliosis in epileptic brain
Choi, J. H.; Kim, H.; Wang, S.; Cai, Y.; Achanta, A.; Pamujula, S.; Thange, H. M.; Shtrahman, M.; Rho, J. M.
10.1101/2025.04.11.647636 — neuroscience — Posted on 2025-04-12
3121 Aboveground fungal lethal effects of local plants on invasive plant Ageratina adenophora seedlings
Zeng, Z.-Y.; Liu, Z.-Q.; Yang, A.-L.; Li, Y.-X.; Wang, Y.-L.; Siemann, E.; Li, B.; Zhang, H.-B.
10.1101/2025.01.21.634076 — ecology — Posted on 2025-04-12
3122 IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models
Singh, K.; Hotchkiss, K. M.; Cook, S. L.; Noldner, P.; Zhou, Y.; Moelker, E. M.; Railton, C. O.; Blandford, E. E.; Puviindran, B. J.; Wallace, S. E.; Norberg, P. K.; Archer, G. E.; Shaz, B. H.; Ayasoufi, K.; Sampson, J. H.; Khasraw, M.; Fecci, P. E.
10.1101/2024.04.01.587634 — cancer biology — Posted on 2025-04-12
3123 Resilience and vulnerabilities of tumor cells under purine shortage stress
Yu, J.; Jin, C.; Su, C.; Moon, D.; Sun, M.; Zhang, H.; Jiang, X.; Zhang, F.; Tserentsoodol, N.; Bowie, M. L.; Pirozzi, C. J.; George, D. J.; Wild, R.; Gao, X.; Ashley, D. M.; He, Y.; Huang, J.
10.1101/2025.03.19.644180 — cancer biology — Posted on 2025-04-12
3124 A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion
Hotchkiss, K. M.; Zhang, K.; Corcoran, A. M.; Owens, E.; Noldner, P.; Railton, C.; Van Batavia, K.; Zhou, Y.; Jepson, J.; Singh, K.; McLendon, R.; Batich, K.; Patel, A. P.; Ayasoufi, K.; Brown, M. C.; Calabrese, E.; Xie, J.; Conejo-Garcia, J.; Shaz, B. H.; Hickey, J. W.; Khasraw, M.
10.1101/2025.03.26.645566 — cancer biology — Posted on 2025-04-12
3128 Mapping the canine microbiome: Insights from the Dog Aging Project
Bamberger, T.; Muller, E.; Algavi, Y. M.; Greenier, A.; Adjangba, C.; Slikas, E.; Brassington, L.; Mariner, B.; McCoy, B.; Harrison, B. R.; Partida-Aguilar, M.; Marye, A.; Harris, A.; Rout, E.; DAP Consortium, ; Avery, A.; Promislow, D. E. L.; Snyder-Mackler, N.; Borenstein, E.
10.1101/2024.12.02.625632 — microbiology — Posted on 2025-04-12
3129 IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency
Sullivan, O. M.; Nesbitt, D. J.; Schaack, G. A.; Feltman, E.; Nipper, T.; Kongsomros, S.; Reed, S. G.; Nelson, S. L.; King, C. R.; Shishkova, E.; Coon, J. J.; Mehle, A.
10.1101/2025.02.17.638785 — microbiology — Posted on 2025-04-12
3130 Self-Supervised Grid Cells Without Path Integration
Pettersen, M.; Schoyen, V. S.; Ostby, M. D.; Malthe-Sorenssen, A.; Lepperod, M. E.
10.1101/2024.05.30.596577 — neuroscience — Posted on 2025-04-12
3131 Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways
Batista, R. A.; Durand, E.; Mörchen, M.; Azevedo-Favory, J.; Simon, S.; Dubin, M.; Kumar, V.; Lacoste, E.; Cruaud, C.; Blassiau, C.; Barois, M.; Holl, A.-C.; Ponitzki, C.; Faure, N.; Marande, W.; Vautrin, S.; Fobis-Loisy, I.; Aury, J.-M.; Legrand, S.; Krämer, U.; Lagrange, T.; Vekemans, X.; Castric, V.
10.1101/2024.05.01.591913 — plant biology — Posted on 2025-04-12
3133 The differential effect of glutamine supplementation on the orthotopic and subcutaneous growth of two syngeneic murine models of glioma
Maurer, J.; Mukherjee, P.; Ta, N.; Lee, D. C.; Duraj, T.; Henao, J.; Kiebish, M.; Van Cura, D.; Herdocia, M.; Seyfried, T. N.
10.1101/2025.04.07.647607 — cancer biology — Posted on 2025-04-12
3134 Dual Targeting for Enhanced Tumor Immunity: Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid-Driven T-Cell Activation
Thisted, T.; Smith, F. D.; Jiang, Z.-G.; Onumajuru, A.; Biesova, Z.; Kleschenko, Y.; Malhotra, K.; Saxena, V.; Mukherjee, A.; van der Horst, E. H.
10.1101/2025.04.07.647657 — cancer biology — Posted on 2025-04-12
3135 Metabolic buffering suppresses phenotype switching in cancer
Ramirez-Sanchez, A.; Jociles-Ortega, M.; Garcia-Martinez, J. M.; Torrens-Martinez, I.; Martinez-Useros, J.; Fernandez-Acenero, M. J.; Olmos-De Blas, T.; Louphrasitthiphol, P.; Goding, C. R.; Garcia-Jimenez, C.; Chocarro-Calvo, A.
10.1101/2025.04.07.647576 — cancer biology — Posted on 2025-04-12
3137 Mapping brain function underlying naturalistic motor observation and imitation using high-density diffuse optical tomography
Yang, D.; George, T.; Sobolewski, C.; McMorrow, S.; Pacheco, C.; King, K.; Rochowiak, R.; Daniels-Day, E.; Park, S.; Speh, E.; Crocetti, D.; Nebel, M. B.; Tuncgenc, B.; Vidal, R.; Marrus, N. M.; Mostofsky, S. H.; Eggebrecht, A. T.
10.1101/2025.01.21.634109 — neuroscience — Posted on 2025-04-12
3138 Inferring genotype-phenotype maps using attention models
Rijal, K.; Holmes, C. M.; Petti, S.; Reddy, G.; Desai, M. M.; Mehta, P.
10.1101/2025.04.11.648465 — genetics — Posted on 2025-04-11
3141 Vowel-like patterns modulate auditory P100m response but not its association with language abilities in children with ASD
Fadeev, K. A.; Romero Reyes, I. V.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Rytikova, A. M.; Novikov, A. Y.; Stroganova, T. A.; Orekhova, E. V.
10.1101/2025.04.10.648101 — neuroscience — Posted on 2025-04-11
3144 Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex
Leman, D. P.; Cary, B. A.; Bissen, D.; Lane, B. J.; Shanley, M. R.; Wong, N. F.; Bhut, K. B.; Turrigiano, G. G.
10.1101/2025.04.11.648036 — neuroscience — Posted on 2025-04-11
3147 Dissecting the genetic basis of drought escape across multiple traits in colonizing Arabidopsis thaliana lineages
Elfarargi, A. F.; Gilbault, E.; Doring, N.; Dinis, H.; Weber, A. P. M.; Loudet, O.; Hancock, A. M.
10.1101/2025.04.07.647068 — genomics — Posted on 2025-04-11
3148 Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris
Taks, N. W.; van Hulten, M.; van Splunter-Berg, J. A.; Chatterjee, S.; Stevens, F. D.; Paauw, M.; Pfeilmeier, S.; van den Burg, H. A.
10.1101/2024.06.20.599835 — plant biology — Posted on 2025-04-11
3149 Highly Multiplexed 3D Profiling of Cell States and Immune Niches in Human Tumours
Yapp, C.; Nirmal, A. J.; Zhou, F. Y.; Wong, A. Y. H.; Tefft, J.; Lu, Y. D.; Shang, Z.; Maliga, Z.; Montero Llopis, P.; Murphy, G. F.; Lian, C.; Danuser, G.; Santagata, S.; Sorger, P. K.
10.1101/2023.11.10.566670 — cancer biology — Posted on 2025-04-11
3150 Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging
Williamson, D. J.; Zaza, C.; Carlon Andres, I.; Gentili, A.; Daly, J. I.; Holmes, H.; Thrush, J.; Starling, T.; Neil, S.; Owens, R.; Malim, M. M.; Tynan, C.; Simoncelli, S.; Padilla-Parra, S.
10.1101/2025.04.11.648405 — biophysics — Posted on 2025-04-11
3153 A genotype-phenotype transformer to assess and explain polygenic risk
Lee, I.; Wallace, Z.; Wang, Y.; Park, S.; Nam, H.; Majithia, A.; Ideker, T.
10.1101/2024.10.23.619940 — bioinformatics — Posted on 2025-04-11
3155 PERSEUcpp: A machine learning strategy to predictcell-penetrating peptides and their uptake efficiency
Loch, R. M.; Almeida, G. O.; Brasiliano, I.; meira, W.; Montanha, D.; Baracat, C.; Silveira, S.
10.1101/2025.04.07.647598 — bioinformatics — Posted on 2025-04-11
3156 Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries
Zhao, H.; Li, X.; Yao, X.; Zhang, S.; Bao, Y.; Lu, W.; Xing, M.; Wang, X.; Wang, X.; Zhao, Y.; Chu, Q.; Lu, X.
10.1101/2025.04.10.648295 — biochemistry — Posted on 2025-04-11
3157 Computational Design of Metallohydrolases
Kim, D.; Woodbury, S. M.; Ahern, W.; Tischer, D.; Hanikel, N.; Salike, S.; Yim, J.; Pellock, S. J.; Lauko, A.; Kalvet, I.; Hilvert, D.; Baker, D.
10.1101/2024.11.13.623507 — biochemistry — Posted on 2025-04-11
3159 In vitro Activity of Citrus IntegroPectin against Breast Cancer and Colon Cancer
D'Anna, C.; Di Sano, C.; Li Petri, G.; Angellotti, G.; Ciriminna, R.; Pagliaro, M.
10.1101/2025.04.11.648349 — biochemistry — Posted on 2025-04-11
3162 Ancient pangenomic origins of noncanonical NLR genes underlying the recent evolutionary rescue of a staple crop
VanGessel, C. J.; Felderhoff, T. J.; Prigozhin, D. M.; Cui, M.; Pressoir, G.; Healey, A. L.; Lovell, J. T.; Nalam, V. J.; Nishimura, M. T.; Morris, G. P.
10.1101/2025.04.11.648396 — genetics — Posted on 2025-04-11
3164 On the path to reference genomes for all biodiversity: lessons learned and laboratory protocols created in the Sanger Tree of Life core laboratory over the first 2000 species
Howard, C.; Denton, A.; Jackson, B.; Bates, A.; Jay, J.; Yatsenko, H.; Raman, P. S.; Thomas, A.; Oatley, G.; do Amaral, R. V.; Göktan, Z. E.; Gomez, J. P. N.; Clayton Lucey, I.; Sinclair, E.; Quail, M. A.; Blaxter, M.; Howe, K.; Lawniczak, M.
10.1101/2025.04.11.648334 — molecular biology — Posted on 2025-04-11
3165 Reference Point-Dependent Reinforcement Learning in Humans and Rats
Ferguson, L.; Soukopova, M.; Bouret, S.; Palminteri, S.; Parkes, S.
10.1101/2025.04.11.648377 — molecular biology — Posted on 2025-04-11
3167 Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy
Liffner, B.; Alves e Silva, T. L.; Glennon, E.; Primavera, V. I.; Hoffman, E. A.; Kaushansky, A.; Vega-Rodriguez, J.; Absalon, S.
10.1101/2025.04.09.648058 — microbiology — Posted on 2025-04-11
3169 Virulence of Fusarium oxysporum strains causing corneal or plant disease is associated with their accessory chromosomes
Ayhan, D. H.; Abbodante, S.; Martinez Soto, D.; Wu, S.; Rodriguez-Vargas, R.; Milo Cochavi, S.; Rickelton, K.; Kotera, S.; Sohrab, V.; Arie, T.; Marshall, M. E.; Rocha, M. C.; Haridas, S.; Grigoriev, I.; Shlezinger, N.; Pearlman, E. S.; Ma, L.-J.
10.1101/2024.05.23.595639 — microbiology — Posted on 2025-04-11
3171 Amplicon sequencing detects, identifies, and quantifies minority variants in mixed-species infections of Cryptosporidium parasites
Turner, R.; Naguib, D.; Pierce, E.; Li, A.; Valente, M.; Glenn, T.; Rosenthal, B. M.; Kissinger, J. C.; Khan, A.
10.1101/2025.04.10.648298 — microbiology — Posted on 2025-04-11
3172 Exploring Population Differences in the Human Gut Microbiome: from Microbial Abundance to Single Nucleotide Polymorphisms
WANG, J.; Zhang, Z.; Chen, Y.; Zhou, X.; Xiang, J.; Yang, C.; Rodionov, D. A.; Osterman, A. L.; Qiu, Q.; Deng, Y.; Liu, Y.; Wang, C.; Shang, X.; Huang, L.; Sun, C.; Guo, J.; Yang, Z.; Han, L.; Zhai, L.; Bian, Z.; Jia, W.; Fang, X.; Zhang, L.
10.1101/2025.04.10.648293 — microbiology — Posted on 2025-04-11
3173 Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection
Dominguez-Cervan, H.; Barrientos-Moreno, L.; Diaz-Martinez, L.; Murillo, J.; Perez-Dorado, I.; Ramos, C.; Rodriguez-Moreno, L.
10.1101/2025.04.11.648327 — microbiology — Posted on 2025-04-11
3175 Infection dynamics and virulence potential of clinical Pseudomonas aeruginosa isolates in a human airway epithelium model system
Colque, C. A.; Lolle, S.; La Rosa, R.; Pals Bendixen, M.; Simoes, F. B.; Aenaes, K.; Molin, S.; Johansen, H. K.
10.1101/2025.04.11.644308 — microbiology — Posted on 2025-04-11
3179 Prevention of Transgene Silencing During Human PluripotentStem Cell Differentiation
Uenaka, T.; Napole, A. B.; Saha, A. D.; Sun, D.; Singavarapu, A.; Calzada, L.; Chen, J.; Erlebach, L.; McQuade, A.; Ramos, D.; Rigamonti, A.; Salazar, L.; Samelson, A. J.; Sedov, K.; Welsh, N. J.; Wild, K.; Wu, Q.; Arenas, E.; Bassett, A. R.; Kampmann, M.; Kronenberg-Versteeg, D.; Merkle, F. T.; Schule, B.; Thompson, L. M.; Skarnes, W. C.; Ward, M. E.; Wernig, M.
10.1101/2025.04.07.647695 — neuroscience — Posted on 2025-04-11
3180 Conjugated GLP-1 and Estradiol Treatment as a Novel Treatment for Age-related Cognitive Decline in Males and Females
Richard, J.; Mohammed, A.; Go, K.; McGovern, A.; Rechlin, R.; Splinter, T.; Lieblich, S.; Radovic, L.; Feng, L.; Blankers, S.; Yang, B.; Douros, J.; Finan, B.; Galea, L. A.
10.1101/2025.04.07.647672 — neuroscience — Posted on 2025-04-11
3182 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy
Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — systems biology — Posted on 2025-04-11
3184 Fibro-Adipogenic Progenitors require autocrine IGF-I in homeostatic and regenerating skeletal muscle
Luo, Y. E.; Abe-Teh, Z.; Alsaghir, T.; Kuo, L.-Y.; Yu, F.; Stoker, B. E.; Appu, A. B.; Zhou, Y.; Yue, F.; Kopinke, D.; Barton, E.
10.1101/2025.04.11.648330 — molecular biology — Posted on 2025-04-11
3186 Light-Controlled Synthetic Communication Networks via Paired Connexon Nanopores
Sihorwala, A. Z.; Lin, A. J.; Ramirez-Velez, I.; Yang, S.; Chowdhury, S.; Stachowiak, J. C.; Belardi, B.
10.1101/2025.04.11.648033 — synthetic biology — Posted on 2025-04-11
3187 Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion
Koleske, B.; Rajagopalan, S.; Schill, C.; Lun, S.; Vilcheze, C.; Das, L.; Gupta, M.; Martinez-Martinez, Y. B.; Jacobs, W. R.; Bishai, W. R.
10.1101/2025.04.11.648440 — microbiology — Posted on 2025-04-11
3189 Age and maturation stage linked consequences of fibrinogen on human oligodendroglia
Blaszczyk, G. J.; Weng, C.; Mohammadnia, A.; Cui, Q. L.; Giurleo, A.; Groh, A. M. R.; Plouffe, C.; Sirois, J.; Piscopo, V. E. C.; Yaqubi, M.; Taqvi, A.; Cassidy, E.; Hall, J. A.; Dudley, R. W. R.; Srour, M.; Zandee, S. E. J.; Klement, W.; Larouche, S.; Prat, A.; Durcan, T. M.; Stratton, J. A.; Antel, J. P.; Moore, G. R. W.
10.1101/2024.05.27.596068 — neuroscience — Posted on 2025-04-11
3192 A map of integrated cis-regulatory elements enhances gene regulatory analysis in maize
Staut, J.; Manosalva Perez, N.; Matres Ferrando, A.; Dissanayake, I.; Vandepoele, K.
10.1101/2024.08.01.606127 — bioinformatics — Posted on 2025-04-11
3194 Complex genetic determinism of male-fertility restoration in the gynodioecious snail Physa acuta
Skarlou, E.; Laugier, F.; Bethune, K.; Chenin, T.; Donnay, J.-M.; Froissard, C.; David, P.
10.1101/2024.08.08.607164 — evolutionary biology — Posted on 2025-04-11
3195 Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors
Jiao, D.; Chang, K.; Chen, Y.; Jin, J.; Ren, M.; Zhang, Y.; Gao, K.; Xu, Y.; Wang, L.; Wang, C.
10.1101/2024.04.24.590941 — cell biology — Posted on 2025-04-11
3196 The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes
Kong, B.; L'Yi, S.; Ramirez-Hernandez, E. G.; Hong, S.; Weidenspointner, R.; Song, S.; Caserta, C.; Cho, Y. M.; Kory, N.
10.1101/2025.04.09.647991 — cell biology — Posted on 2025-04-11
3198 Characterizing Oligodendrocyte-Lineage Cells and Myelination in the Basolateral Amygdala: Insights from a Novel Methodology in Postmortem Human Brain
Perlman, K.; Curto, E.; Barnett-Burns, S.; Davoli, M.-A.; Yerko, V.; Merza, R.; Papadakis, A. I.; Spatz, A.; Pryce, C. R.; Turecki, G.; Mechawar, N.
10.1101/2025.01.09.631560 — neuroscience — Posted on 2025-04-11
3199 Spheroplasted cells: a game changer for DNA delivery to diatoms
Walker, E. J. L.; Pampuch, M.; Deng, L.; Li, Y.; Tran, G.; Mock, T.; Karas, B. J.
10.1101/2024.10.10.617634 — synthetic biology — Posted on 2025-04-11
3200 Cryopreservation of Human Cortical Organoids Using Vitrification.
Mojica-Perez, S.; Stokes, K.; Jacobs, S.; Huang, J.; Vaid, S.; Yuan, y.; Pearson, C. A.; Montes, D.; Tidball, A.; VanHeyningen, D.; Gaillard, J.; Dang, L. T.; Ross, M. E.; Isom, L. L.; Uhler, M.; Niu, W.; Parent, J. M.
10.1101/2025.04.08.647634 — neuroscience — Posted on 2025-04-11
3204 Immunomodulation by AZD1656 reverses cardiac dysfunction, metabolic remodelling and reduces infarct size in type 2 diabetic cardiomyopathy
Anderson, S.; Karlstaedt, A.; Chen, J.; O'Riordan, C.; Barnes, M.; Staka, Z.; Albee, L.; Garrod-Ketchley, C.; Vithanachchi, S.; Prag, H.; Cvetko, F.; Thiemermann, C.; Lewis, A. J.; Murphy, M. P.; Smith, D. M.; Henson, S.; Tyler, D.; Aksentijevic, D.
10.1101/2025.04.10.648128 — physiology — Posted on 2025-04-11
3205 On the ancestry and evolution of the extinct dire wolf
Gedman, G.; Morrill Pirovich, K.; Oppenheimer, J.; Hyseni, C.; Cassatt-Johnstone, M.; Alexandre, N.; Troy, W.; Chao, C.; Fedrigo, O.; Hoyt, S. J.; Grady, P. G. S.; Sacco, S.; Seligmann, W.; Dash, A.; Chokshi, M.; Knecht, L.; Papizan, J. B.; Miyawaki, T.; Bocklandt, S.; Kelher, J.; Ord, S.; Lin, A. T.; Peecook, B.; Perri, A.; Sinding, M.-H. S.; Larson, G.; Meachen, J.; Dalen, L.; vonHoldt, B.; Gilbert, M. T. P.; Mason, C. E.; O'Neill, R. J.; Karlsson, E.; Cantarel, B. L.; Martin, G. R. R.; Church, G.; Lamm, B.; Shapiro, B.
10.1101/2025.04.09.647074 — evolutionary biology — Posted on 2025-04-11
3206 Invasive Aedes vittatus mosquitoes in Jamaica: A looming public health concern
Noble, S. A. A.; Ali, R. L. M. N.; Wilson-Clarke, C. F.; Khouri, N. K.; Norris, D. E.; Sandiford, S. L.
10.1101/2025.04.10.648144 — ecology — Posted on 2025-04-11
3210 rsofun v5.0: A model-data integration framework for simulating ecosystem processes
Aran Paredes, J.; Hufkens, K.; Marcadella, M.; Bernhard, F.; Stocker, B. D.
10.1101/2023.11.24.568574 — ecology — Posted on 2025-04-11
3212 Extra-cellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: a potential driver of prostate cancer aggressiveness
Esteve, D.; Toulet, A.; Roumiguie, M.; Bu, D.; Lacombe, M.; Pericart, S.; Belles, C.; Manceau, C.; Houel, C.; Ducoux-Petit, M.; Van Acker, N.; Dauvillier, S.; Jia, Y.; Hernandez, M.; Moutahir, M.; Franchet, C.; Doumerc, N.; Thoulouzan, M.; Le Gonidec, S.; Valet, P.; Malavaud, B.; Burlet-Schiltz, O.; Bouloumie, A.; Scherer, P. E.; Milhas, D.; Muller, C.
10.1101/2023.01.05.522843 — cancer biology — Posted on 2025-04-11
3213 Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids.
Willott, T. O.; Nicholson, J. G.; Xiao, Y.; Ogunbiyi, O. K.; Draper, B.; Mistry, T.; Donovan, L.; Zabet, N. R.; Merve, A.; Badodi, S.; Marino, S.
10.1101/2024.08.14.607977 — cancer biology — Posted on 2025-04-11
3214 The nuclear egress complex of MHV-68 is not essential for nuclear egress but mediates C-capsid specificity
Sanders, S.; Schneider, C.; Soh, T. K.; Kotova, E.; Steer, B.; Reimer, R.; Ruzsics, Z.; Adler, H.; Bosse, J.
10.1101/2025.04.10.648238 — microbiology — Posted on 2025-04-11
3215 Myxobacteria isolated from RAS: Ecology and significance as off-flavor producers
Södergren, J.; Noguera, P. M.; Petersen, M. A.; Jorgensen, N. O. G.; Podduturi, R.; Nicolaisen, M. H.
10.1101/2025.04.10.648225 — microbiology — Posted on 2025-04-11
3216 VH-replacement shapes the antibody repertoire by targeting non-pairing heavy-chains
White, H. N.; Chovanec, P.; Biggins, L.; French, E. C.; Bullen, G.; Andrews, S.; Corcoran, A. E.
10.1101/2025.04.07.647564 — immunology — Posted on 2025-04-11
3219 Next-level high-precision spatial omics enabled through spatial similarity networking
Sharma, V. V.; Toth, G.; Martinis, R.; Hansen, C. E.; Kooij, G.; Lanekoff, I.
10.1101/2025.03.07.642022 — neuroscience — Posted on 2025-04-11
3222 Molecular architecture of thylakoid membranes within intact spinach chloroplasts
Wietrzynski, W.; Lamm, L.; Wood, W. H. J.; Loukeri, M.-J.; Malone, L.; Peng, T.; Johnson, M. P.; Engel, B. D.
10.1101/2024.11.24.625035 — plant biology — Posted on 2025-04-11
3225 Conditional deletion of Tmem63b does not impact mouse voiding behavior
Dalghi, M. G.; Ruiz, W. G.; Clayton, D. R.; Parakala-Jain, T.; Carattino, M. D.; Shi, Y. S.; Apodaca, G.
10.1101/2025.04.07.647591 — physiology — Posted on 2025-04-11
3226 The Role of N-acetylcysteine Amide in Acute Graft-versus-host Disease Mouse Model
He, R.; Zheng, W.; Rozing, K.; Moro, C. F.; Li, X.; Yin, Y.; Zhou, W.; Andaloussi, S. E.; Norgren, S.; Zhao, Y.; Hassan, M.
10.1101/2025.04.07.647501 — pharmacology and toxicology — Posted on 2025-04-11
3227 A novel antioxidant N-acetylcysteine Amide Alleviates Cyclophosphamide-induced Endothelial Damage
He, R.; Zheng, W.; Slof, T.; Wardell, E.; Mansson-Broberg, A.; Norgren, S.; Zhao, Y.; Hassan, M.
10.1101/2025.04.07.647539 — pharmacology and toxicology — Posted on 2025-04-11
3228 Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cancer cells evaded by BACH1
Rokugo, M.; Nakamura, K.; Matsumoto, M.; Endo, A.; Nguyen, L. C.; Nishizawa, H.; Shima, R.; Kashiwagi, H.; Okoshi, A.; Nakanome, A.; Funayama, R.; Nakayama, K.; Ogawa, T.; Abe, T.; Katori, Y.; Igarashi, K.
10.1101/2025.04.07.647470 — cancer biology — Posted on 2025-04-11
3229 FLASH radiotherapy spares lymphocytes in tumor-draining lymph nodes and increases infiltration of immune cells in tumors
Saenz, F. R.; Velasquez, B.; Waldrop, T.; Aguilar, E.; Cox, K. R.; Delahoussaye, A.; Laberiano-Fernandez, C.; Campos Clemente, L.; Connell, L.; Mims, N.; Neill, D.; Parra, E. R.; Clise-Dwyer, K.; Schueler, E.; Spiotto, M. T.
10.1101/2025.04.07.647544 — cancer biology — Posted on 2025-04-11
3230 Structures of protein folding intermediates on the ribosome
Chan, S. H. S.; Streit, J. O.; Wlodarski, T.; Mitropoulou, A.; Cabrita, L. D.; Christodoulou, J.
10.1101/2025.04.07.647236 — biophysics — Posted on 2025-04-11
3231 Mechanical control of tissue growth during limb regeneration
Edwards-Jorquera, S.; Ceccarelli, A.; Schlüssler, R.; Murali Shankar, N.; Munoz Ovalle, A.; Gentleman, K.; Freudenberg, U.; Werner, C.; Chara, O.; Taubenberger, A. V.; Sandoval-Guzman, T.
10.1101/2025.04.07.647008 — biophysics — Posted on 2025-04-11
3237 Effects of Soft Encapsulation on the Receive Performance of PMUTs for Implantable Devices
Velea, A. I.; Panskus, R.; Szabo, B.; Oppelt, V. A.-L.; Holzapfel, L.; Karuthedath, C. B.; Sebastian, A. T.; Stieglitz, T.; Savoia, A. S.; Giagka, V.
10.1101/2025.04.07.646993 — bioengineering — Posted on 2025-04-11
3238 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells
Delhaye, L.; Rombaut, D.; de Bony, E. J.; D'haene, E.; Brazao, T. F.; Depestel, L.; Decaesteker, B.; Van Haver, S.; Martinez, R.; Dipalo, L. L.; Roels, J.; Verniers, K.; Yigit, N.; Anckaert, J.; Menten, B.; Vergult, S.; Van Vlierberghe, P.; Roberts, S.; Milazzo, G.; Perini, G.; Sanda, T.; Speleman, F.; Eyckerman, S.; Mestdagh, P.
10.1101/2025.04.07.647560 — genetics — Posted on 2025-04-11
3240 Wuhan sharpbelly bornavirus (genus Cultervirus) can infect a wide range of host cells and establishes persistent infection in diverse cypriniform cells
Eshak, M. I. Y.; Breithaupt, A.; Tews, B. A.; Luttermann, C.; Franzke, K.; Scheibe, M.; Woelke, S.; Rubbenstroth, D.; Beer, M.; Pfaff, F.
10.1101/2025.03.26.645528 — molecular biology — Posted on 2025-04-11
3244 Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain
Nikitina, N.; Wadsworth, J.; Goelzer, M.; Goldfeldt, M.; Bursa, N.; Howard, S.; Crandall, C.; Semodji, A.; Zavala, A. G.; Judex, S.; Rubin, J.; Lujan, T. J.; Fitzpatrick, C. K.; Rubin, C. T.; Satici, A.; Uzer, G.
10.1101/2025.04.07.647583 — bioengineering — Posted on 2025-04-11
3245 An update to the global Critical Habitat layer
Dunnett, S.; Muge, A.; Ross, A.; Turner, J. A.; Burgess, N. D.; Jones, M. I.; Brooks, S.
10.1101/2025.04.01.646588 — ecology — Posted on 2025-04-11
3246 Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium
McCabe, M.; Groves, H. E.; Getty, E.; Campbell, E.; Bamford, C. G. G.; Lopez Campos, G.; Shields, M. D.; Power, U. F.
10.1101/2025.04.08.647778 — microbiology — Posted on 2025-04-11
3252 Spatial artefact detection improves reproducibility of drug screening experiments
Ianevski, A.; Nader, K.; Potdar, S.; Gorbonos, A.; Ianevski, F.; Tanoli, Z.; Saarela, J.; Aittokallio, T.
10.1101/2025.04.07.647506 — bioinformatics — Posted on 2025-04-11
3253 Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1
Kanai, M.; Mok, S.; Yeo, T.; Shears, M. J.; Jeon, J. H.; Narwal, S. K.; Ross, L. S.; Haile, M. T.; Tripathi, A. K.; Mlambo, G.; Kim, J.; Gil-Iturbe, E.; Okombo, J.; Park, H.; Wiradiputri, K.; Ward, K. E.; Rozenberg, F. D.; Fairhurst, K. J.; Bloxham, T. S.; Bridgford, J. L.; Sheth, T. R.; Lee, M. C.; Small-Saunders, J. L.; Mancia, F.; Quick, M.; Uhlemann, A.-C.; Sinnis, P.; Fidock, D. A.
10.1101/2024.09.27.615529 — genetics — Posted on 2025-04-11
3254 Bird population trend analyses for a monitoring scheme with a highly structured sampling design
Rieger, M. R.; Grueneberg, C.; Oberhaus, M.; Trautmann, S.; Parepa, M.; Anthes, N.
10.1101/2024.06.30.601382 — ecology — Posted on 2025-04-11
3255 Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands
Chen, Q.; Blowes, S.; Harpole, S.; Ladouceur, E.; Borer, E.; MacDougall, A.; Bakker, J. D.; Tognetti, P. M.; Seabloom, E. W.; Daleo, P.; Martina, J.; Roscher, C.; Adler, P.; Wheeler, G.; Estrada, C.; Stevens, C.; Veen, C.; Risch, A. C.; Donohue, I.; Hautier, Y.; Wardle, G.; Haider, S.; Hersch-Green, E.; Niu, Y.; Peri, P. L.; Power, S. A.; Eskelinen, A.; Gruner, D.; Olde Venterink, H.; D'Antonio, C.; Cadotte, M.; Eisenhauer, N.; Virtanen, R.; Catford, J.; Morgan, J.; Tedder, M.; Bagchi, S.; Maria, C.; Bugalho, M.; Knops, J.; Dickman, C.; Hagenah, N.; Jentsch, A.; Macek, P.; Osborne, B.; Laanist
10.1101/2024.03.27.586835 — ecology — Posted on 2025-04-11
3257 Effects of biological and environmental factors on orthoebolavirus serology in bats in Guinea
Champagne, M.; Cappelle, J.; Caron, A.; Pouliquen, T.; Samoura, A.; Doumbouya, M. I.; Thaurignac, G.; Soumah, A. K.; Ayouba, A.; Keita, A. K.; Peeters, M.; Bourgarel, M.; De Nys, H. M.
10.1101/2023.08.23.554395 — microbiology — Posted on 2025-04-11
3258 α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
Mukhtar, T.; Siebert, C.-V.; Wang, Y.; Pebworth, M.-P.; White, M. L.; Wu, T.; Huang, T. I.; Zuo, G.; Ross, J.; Baltazar, J.; Upadhyay, V.; Shankar, M.; Zhou, L.; Lombardi-Coronel, I.; Mandala, I.; Adam, M. A.; Wang, S.; Bi, Q.; Hoekman, M. F. M.; Li, J.; Kriegstein, A.
10.1101/2025.04.10.647795 — neuroscience — Posted on 2025-04-11
3263 The Role of Pace of Life in Animal Social Networks
Walker, R. S.; White, A.; O'Neill, X.; Fefferman, N. H.; Silk, M. J.
10.1101/2025.04.10.648003 — ecology — Posted on 2025-04-10
3264 DTX4 regulates neural progenitor transitions during cortical development
Pedersen, E.; Zhang, S.; Dong, X.; Vallone, V. F.; Epifanova, E.; Willecke, P. M.; Lajko, D.; Schaub, T.; Ambrozkiewicz, M. C.; Textoris-Taube, K.; Stachelscheid, H.; Rosario, M.
10.1101/2025.04.10.648213 — neuroscience — Posted on 2025-04-10
3265 Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth and behavioral phenotypes in mice.
Genoud, S.; Porto, R. R.; Stefen, H.; Tomanic, T.; Paric, E.; Sarkar, S.; Yoo, D.; Gao, W.; Hardeman, E. C.; Gunning, P. W.; Karl, T.; Power, J.; Fath, T.
10.1101/2025.04.10.648285 — neuroscience — Posted on 2025-04-10
3266 Glycogen metabolism acts in neurons to support glycolytic plasticity
Singh, M.; Wolfe, A. D.; Vishwanath, A. A.; Tsives, A.; Gonzalez, I. J.; Emerson, S. E.; Goodman, R. H.; Colon-Ramos, D.
10.1101/2025.04.10.648039 — neuroscience — Posted on 2025-04-10
3267 α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
Kriegstein, A.; Mukhtar, T.; Siebert, C.-V.; Wang, Y.; Pebworth, M.-P.; White, M. L.; Wu, T.; Huang, T. I.; Zuo, G.; Ross, J.; Baltazar, J.; Upadhyay, V.; Shankar, M.; Zhou, L.; Lombardi-Coronel, I.; Mandala, I.; Adam, M. A.; Wang, S.; Bi, Q.; Hoekman, M. F. M.; Li, J.
10.1101/2025.04.10.647795 — neuroscience — Posted on 2025-04-10
3269 Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes
Yamauchi, Y.; Zhou, X. D.; Tarfder, R.; Rouillard, P.; Bilgic, M.; Deguchi, S.; Nakamura, T.; Kishi, Y.; Emoto, K.; Suzuki, I. K.
10.1101/2025.04.10.648214 — developmental biology — Posted on 2025-04-10
3272 High-throughput histopathology for complex in vitro models
Harter, M. F.; D'Arcangelo, E.; Aubert, J.; Lavickova, B.; Havnar, C.; Stoll, B.; Cubela, I.; Filip, A. M.; Gaspa-Toneu, L.; Scherer, J.; Karagkiozi, E.; Dupre, J.-S.; Lopez-Sandoval, R.; Hsia, R.; Norona, L.; Brancati, G.; Okuda, R.; Camp, G.; Shamir, E.; Garcia-Cordero, J. L.; Pereiro, I.; Gjorevski, N.
10.1101/2025.04.01.646522 — pathology — Posted on 2025-04-10
3276 Lung microbiomes variable responses to dust exposure
Maltz, M. R.; Topacio, T.; Lo, D. D.; Freund, L.; Zaza, M.; Botthoff, J. K.; Swenson, M.; Cocker, D.; Biddle, T.; Yisrael, K.; Castillo, D. d.; Drover, R.; Aronson, E. L.
10.1101/2025.04.10.648223 — molecular biology — Posted on 2025-04-10
3279 Spatial artefact detection improves reproducibility of drug screening experiments
Ianevski, A.; Nader, K.; Potdar, S.; Gorbonos, A.; Ianevski, F.; Tanoli, Z.; Saarela, J.; Aittokallio, T.
10.1101/2025.04.07.647506 — bioinformatics — Posted on 2025-04-10
3280 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy
Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-04-10
3281 Genetic structure of mesophotic and shallow Acropora aculeus on isolated atolls of Eastern Australia
Hernandez-Agreda, A.; Hoey, J. A.; van Hulten, D.; Hernandez, P.; Peplow, L.; Muir, P.; Hoegh-Guldberg, O.; van Oppen, M.; Bongaerts, P.
10.1101/2025.04.08.647879 — genomics — Posted on 2025-04-10
3282 Evidence of distal regulations orchestrated by RNAs initiating at short tandem repeats
Grapotte, M.; Vroland, C.; Garrido-Martin, D.; Vignoli, A.; Calero, L.; Bouvier, Q.; Robin, M.; Yip, C. W.; Carninci, P.; Chatelain, C.; Brehelin, L.; Notredame, C.; Guigo, R.; Lecellier, C. H.
10.1101/2025.04.10.648102 — genomics — Posted on 2025-04-10
3284 Parallel erosion of a testis-specific Na+/K+ ATPase in three mammalian lineages sheds light into the evolution of spermatozoa energetics
Valente, R.; Machado, A.; Pericuesta, E.; Garca-Parraga, D.; Artilheiro, N. A.; Alves, F.; Sousa-Pinto, I.; Pinto, B.; Cordeiro, M.; Ruivo, R.; Gutierrez-Adan, A.; Castro, F.
10.1101/2025.04.07.647512 — evolutionary biology — Posted on 2025-04-10
3285 229E- and NL63-like coronaviruses in phyllostomid bats, Belize
Ansil, B. R.; Lei, G.-S.; Santos, A. J.; Letko, M. C.; Seifert, S. N.; Fenton, B.; Simmons, N. B.; Relich, R. F.; Becker, D. J.
10.1101/2025.04.08.647854 — ecology — Posted on 2025-04-10
3287 Critical Period Plasticity is Associated withResilience to Short Unpredictable Stress
Williams, R.; van den Oord, C.; Lee, E.; Fedde, S.; Oscherwitz, G.; Ribic, A.
10.1101/2025.02.26.640466 — neuroscience — Posted on 2025-04-10
3290 Identification of Monotonically Classifying Pairs of Genes for Ordinal Disease Outcomes
Fourquet, O.; Afenteva, D.; Zhang, K.; Hautaniemi, S.; Krejca, M.; Doerr, C.; Schwikowski, B.
10.1101/2025.04.10.643941 — systems biology — Posted on 2025-04-10
3292 A method to estimate absolute odorant concentration of olfactory stimuli
CONCHOU, L.; TRELEA, I.-C.; GEVAR, J.; MONSEMPES, C.; PERON, A.-C.; RENOU, M.; SOUCHON, I.; LUCAS, P.
10.1101/2025.04.10.648182 — synthetic biology — Posted on 2025-04-10
3293 De novo chemo-optogenetics through rational small-molecule design and TRAP display
Miyazaki, T.; Fujino, T.; Yoshii, T.; Funane, M.; Murata, N.; Kim, C. N.; Nagatoishi, S.; Tsumoto, K.; Hayashi, G.; Murakami, H.; Tsukiji, S.
10.1101/2025.04.10.648175 — synthetic biology — Posted on 2025-04-10
3295 Andrographolide prevents necroptosis by suppressing generation of reactive oxygen species
Lu, N.; Li, Q.; Duan, L.-h.; Xu, R.; Li, Y.-p.; Shi, F.-l.; Zhou, Z.-y.; Gan, Y.-q.; Hu, B.; Li, J.-h.; He, X.-h.; Ouyang, D.-y.; Zha, Q.-b.
10.1101/2025.04.07.647496 — pharmacology and toxicology — Posted on 2025-04-10
3296 Endometrial cancer progression driven by PTEN-deficiency requires miR-424(322)~503.
Vidal-Sabanes, M.; Bonifaci, N.; Navaridas, R.; Egea, J.; Encinas, M.; Rodriguez-Barrueco, R.; Silva, J. M.; Matias-Guiu, X.; Llobet-Navas, D.; Dolcet, X.
10.1101/2025.04.07.647575 — cancer biology — Posted on 2025-04-10
3299 An mTurquoise2-based glucose biosensor
Botman, D.; Tielman, A.; Goedhart, J.; Teusink, B.
10.1101/2024.11.29.626064 — biochemistry — Posted on 2025-04-10
3300 Minimal Correlation but Complementary Diagnostic Utility for Plasma Cell-free RNA and Proteins
Bliss, A.; Loy, C. J.; Kim, J.; Shimizu, C.; Lenz, J. S.; Belcher, E.; Tremoulet, A. H.; Burns, J. C.; De Vlaminck, I.
10.1101/2025.04.09.647972 — genomics — Posted on 2025-04-10
3303 Long-term evolution of prokaryotic genomes in a chemolithotrophic cave over 5.5 million years of isolation
Saati-Santamaria, Z.; Novakova, A.; Carro, L.; Gonzalez-Candelas, F.; Iranzo, J.; Hillebrand-Voiculescu, A. M.; Morais, D.; Vetrovsky, T.; Baldrian, P.; Kolarik, M.; Garcia-Fraile, P.
10.1101/2025.04.10.648229 — microbiology — Posted on 2025-04-10
3304 Structural Basis of Lipopolysaccharide Assembly by the Outer Membrane Translocon Holo-Complex
Chen, H.; Siroy, A.; Morales, V.; Gurvic, D.; Quentin, Y.; Balor, S.; Abuta'a, Y. A.; Marteau, M.; Froment, C.; Caumont-Sarcos, A.; Marcoux, J.; Stansfeld, P. J.; Fronzes, R.; Ieva, R.
10.1101/2025.04.10.648201 — microbiology — Posted on 2025-04-10
3306 An in vivo CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model
Fumagalli, M.; An, D.; Simula, L.; Combe, C.; Aziez, L.; Simoni, Y.; Alves-Guerra, M.-C.; Valentini, A.; Marchais, M.; Vermare, A.; Moraly, J.; Bercovici, N.; Donnadieu, E.; Pendino, F.
10.1101/2025.03.28.645780 — immunology — Posted on 2025-04-10
3309 Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification
Behzadi, P.; Wendling, A. A.; Cuevas, R. A.; Crane, A.; Chu, C. C.; Moorhead, W. J.; Wong, R.; Brown, M.; Tamakloe, J.; Suresh, S.; Saleh, P.; Jaffe, I. A.; Kuipers, A. L.; Lukashova, L.; Verdelis, K.; St. Hilaire, C.
10.1101/2024.08.01.606196 — physiology — Posted on 2025-04-10
3310 Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes
Wang, H.; Ardila, C.; Jindal, A.; Aggarwal, V.; Wang, W.; Vande Geest, J.; Jiang, Y.; Xing, J.; Sant, S.
10.1101/2024.09.18.613706 — cancer biology — Posted on 2025-04-10
3311 Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine
Wulffraat, G. C.; Mamathasateesh, S.; Hudson, R.; He, B.; Jara-Oseguera, A.; Senning, E. N.
10.1101/2025.02.14.638348 — biophysics — Posted on 2025-04-10
3312 Nanoscale curvature of the plasma membrane regulates mechanoadaptation through nuclear deformation and rupture
Francis, E. A.; Sarikhani, E.; Patel, V.; Meganathan, D. P.; Sadr, L.; Jahed, Z.; Rangamani, P.
10.1101/2024.10.18.619165 — biophysics — Posted on 2025-04-10
3313 Discernibility in explanations: an approach to designing more acceptable and meaningful machine learning models for medicine
Wang, H.; Aligon, J.; May, J.; Doumard, E.; Labroche, N.; Delpierre, C.; Soule-Dupuy, C.; Casteilla, L.; Planat, V.; Monsarrat, P.
10.1101/2025.04.06.647498 — bioinformatics — Posted on 2025-04-10
3314 Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins
May, A. J.; Lella, M.; Lindenberger, J.; Berkman, A.; Kumar, U.; Dutta, M.; Barr, M.; Parks, R.; Lu, X.; Berry, M.; Newman, A.; Huang, X.; Song, K.; Ilevbare, V.; Sammour, S.; Park, C. S.; Adhikari, R. D.; Devkota, P.; Janowska, K.; Liu, Y.; Scapellato, G.; Spence, T. N.; Mansouri, K.; Wiehe, K.; Edwards, R. J.; Saunders, K. O.; Haynes, B. F.; Acharya, P.
10.1101/2024.12.11.627382 — biochemistry — Posted on 2025-04-10
3316 Structural evolution of nitrogenase enzymes over geologic time
Cuevas, B.; Detemple, F.; Amritkar, K.; Garcia, A. K.; Seefeldt, L.; Einsle, O.; Kacar, B.
10.1101/2024.11.18.623660 — evolutionary biology — Posted on 2025-04-10
3317 Insulin-dependent and -independent dynamics of insulin receptor trafficking in muscle cells
Cen, H. H.; Mattison, A. J.; Omidi, A.; Rogalski, J.; Abraham, L.; Gao, G.; Gold, M. R.; Foster, L.; Gsponer, J.; Johnson, J. D.
10.1101/2021.06.29.450241 — cell biology — Posted on 2025-04-10
3319 Diffusion-based size determination of solute particles: a method adapted for postsynaptic proteins
Szabo, A. L.; Nagy-Kanta, E.; Varga, S.; Jager, E. A.; Pongor, C. I.; Laki, M.; Laki, A. J.; Gaspari, Z.
10.1101/2025.02.05.636588 — molecular biology — Posted on 2025-04-10
3322 Autonomic Neuropathy is Associated with an Increase in Type-1 Cytokines in People Living with HIV
Mueller, B. R.; Mehta, M.; Campbell, M.; Neupane, N.; Cedillo, G.; Lee, G.; Coyle, K.; Qi, J.; Chen, Z.; George, M. C.; Robinson-Papp, J.
10.1101/2024.10.15.618447 — immunology — Posted on 2025-04-10
3324 A reaction norm for flowering time plasticity reveals physiological footprints of maize adaptation
Drouault, J.; Palaffre, C.; Millet, E. J.; Rodriguez, J.; Martre, P.; Johnson, K.; Parent, B.; Welcker, C.; Wisser, R. J.
10.1101/2024.07.10.602692 — plant biology — Posted on 2025-04-10
3325 Environment-Dependent Modes of Adaptive Evolution in Neuroblastoma: Plasticity as a Selectable Trait
Roux, C.; Hamer, S.; Shea, A.; Chen, E.; Sadr, A. S.; English, C.; Allo Anido, A.; Che, H.; Geoerger, B.; Chesler, L.; Schleiermacher, G.; Morgan, M. D.; Bruna, A.
10.1101/2023.12.07.570359 — cancer biology — Posted on 2025-04-10
3326 IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites
Miller, J. P.; Kim, K.; Khazan, N.; Snyder, C. W.; Singh, N. A.; Lamere, E.; Strawderman, M.; Sharma, S.; Lakony, R.; Whittum, M.; Anderson, M.; Keenan, R.; Pritchett, E.; Baker, C.; Ashton, J.; Khera, M. K.; Chu, C. C.; Bajaj, J.; Elliott, M. R.; Rowswell-Turner, R.; Calvi, L. M.; Becker, M. W.; Moore, R. G.; Singh, R. K.
10.1101/2025.03.18.643950 — cancer biology — Posted on 2025-04-10
3328 Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W.; Yim, J.; Tischer, D.; Salike, S.; Woodbury, S.; Kim, D.; Kalvet, I.; Kipnis, Y.; Coventry, B.; Altae-Tran, H.; Bauer, M.; Barzilay, R.; Jaakkola, T.; Krishna, R.; Baker, D. A.
10.1101/2025.04.09.648075 — biochemistry — Posted on 2025-04-10
3329 Impacts of taxonomic change on the Amazonian palm flora
Stropp, J.; Pereira, A. S. S.; Emilio, T.; Meyer, L.; Trad, R.; Alves-Martins, F.; Ladle, R. J.; Hortal, J.
10.1101/2024.11.29.625979 — ecology — Posted on 2025-04-10
3331 An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster
Zung, J. L.; Namiki, S.; Meissner, G. W.; Costa, M.; Eichler, K.; Stürner, T.; Jefferis, G. S. X. E.; Managan, C.; FlyLight Project Team, ; Korff, W.; Card, G. M.
10.1101/2025.02.22.639679 — neuroscience — Posted on 2025-04-10
3332 The interaction of growth with mechanical constraints drives puzzle cell formation in plants
Trozzi, N.; Lane, B.; Perruchoud, A.; Clark, F.; Hoermayer, L.; Meraviglia, A.; Reichgelt, T.; Roeder, A. H. K.; Kwiatkowska, D.; Runions, A.; Smith, R. S.; Majda, M.
10.1101/2023.10.01.560343 — plant biology — Posted on 2025-04-10
3334 Genetic and phenotypic diversity of wine-associated Hanseniaspora species
Onetto, C. A.; Ward, C. M.; Varela, C.; Hale, L.; Schmidt, S.; Borneman, A. R.
10.1101/2025.04.09.648064 — microbiology — Posted on 2025-04-10
3337 Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency
Canova, P. N.; Katzenell, S.; Ceron, S.; Charron, A. J.; Pesola, J. M.; Oh, H. S.; Coen, D. M.; Knipe, D. M.; Leib, D. A.
10.1101/2025.04.04.647253 — immunology — Posted on 2025-04-10
3338 Targeting RET in Brain Metastases from Estrogen Receptor Positive Breast Cancer
Liu, S.; Pecar, G.; Cao, Y.; Chen, F.; Wedn, A.; Atkinson, J. M.; Hooda, J.; Oesterreich, S.; Lee, A. V.
10.1101/2025.04.04.647085 — cancer biology — Posted on 2025-04-10
3339 Histone H3 tail charge patterns govern nucleosome condensate formation and dynamics
Hammonds, E. F.; Singh, A.; Suresh, K. K.; Yang, S.; Meidl Zahorodny, S. S.; Gupta, R.; Potoyan, D. A.; Banerjee, P. R.; Morrison, E. A.
10.1101/2025.04.09.647968 — biophysics — Posted on 2025-04-10
3342 Selectivity profiles and substrate recognition of Rab phosphorylating kinases
Chatterjee, D.; Dederer, V.; Nguyen, L. V.; Wendel, M.; Abdul Azeez, K. R.; Mahesula, S.; Stengel, F.; Reck-Peterson, S.; Mathea, S.
10.1101/2025.04.09.647999 — biochemistry — Posted on 2025-04-10
3343 A Morpho-Proteomic Atlas of Mitosis at Sub-Minute Resolution
Migh, E.; Miczan, V.; Post, F.; Koos, K.; Beleon, A.; Kokai, D.; Ivan, Z. Z.; Grexa, I.; Moshkov, N.; Hollandi, R.; Csikos, D.; Hapek, N.; Kaptas, F.; Kovacs, F.; Kriston, A.; Mahdessian, D.; Axelsson, U.; Pal, C.; Lundberg, E.; Manczinger, M.; Mund, A.; Mann, M.; Horvath, P.
10.1101/2025.04.09.647158 — cell biology — Posted on 2025-04-10
3347 High-risk clonal groups of Avian Pathogenic Escherichia coli (APEC) demonstrate heterogeneous phenotypic characteristics in vitro and in vivo
Adams, J. R. G.; Long, H.; Birdsall, C.; Qureshi, K.; King, E.; Perez, S.; Warner, K.; Behboudi, S.; La Ragione, R. M.; Mehat, J. W.
10.1101/2025.04.10.648166 — microbiology — Posted on 2025-04-10
3349 Gene regulatory network determinants of rapid recall in human memory CD4+ T cells
Katko, A.; Korinfskaya, S.; Bejjani, A. T.; Owoeye, S. M.; Yang, Z. F.; Rudrapatna, A.; Wayman, J. A.; Kotliar, M.; Kottyan, L. C.; Barski, A.; Miraldi, E. R.
10.1101/2025.04.06.646912 — systems biology — Posted on 2025-04-10
3352 Molecular architecture of heterochromatin at the nuclear periphery of primary human cells
Kreysing, J. P.; Cruz-Leon, S.; Betz, J.; Penzo, C.; Majtner, T.; Schreiber, M.; Turonova, B.; Lusic, M.; Hummer, G.; Beck, M.
10.1101/2025.04.09.647790 — biophysics — Posted on 2025-04-10
3356 Acyl-CoA Binding Protein is Dispensable for White and Brown Adipose Tissue Function
Noerremark, M. F.; Petersen, R.; Ruppert, P. M. M.; Doktor, T. K.; Nielsen, R.; Kappel, J. F.; Larsen, S.; Kornfeld, J.-W.; Mandrup, S.; Andresen, B. S.; Havelund, J. F.; Neess, D.; Faergeman, N. J.
10.1101/2025.04.10.642978 — biochemistry — Posted on 2025-04-10
3359 The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes
Kong, B.; Kory, N.; L'Yi, S.; Ramirez-Hernandez, E. G.; Hong, S.; Weidenspointner, R.; Song, S.; Caserta, C.; Cho, Y. M.
10.1101/2025.04.09.647991 — cell biology — Posted on 2025-04-10
3362 Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast
Ma, Z.-H.; Pan, Z.-Q.; Jiang, Z.-D.; Shao, G.-C.; Hua, Y.; Suo, F.; Zou, C.-X.; Jiang, Y.-F.; Dong, M.-Q.; Du, L.-L.
10.1101/2025.04.09.648038 — cell biology — Posted on 2025-04-10
3363 Phosphodiesterase 3A modulators sensitize tumor cells to Bcl-xL and Bcl-2/Bcl-xL inhibitors
Toivanen, K.; Murumagi, A.; Wozniak, A.; Wyns, K.; Wang, C.-C.; De Sutter, L.; Arjama, M.; Merikoski, N.; Salmikangas, S.; Youssef, O.; Isola, J.; Kallioniemi, O.; Schoffski, P.; Bohling, T.; Sihto, H.
10.1101/2025.04.10.648087 — molecular biology — Posted on 2025-04-10
3365 Two Spore Types in a Marine Parasite of Dinoflagellates
Szymczak, J.; Pinaud, S.; Romero Rodriguez, I.; Walde, M.; Kayal, E.; Alves-de-Souza, C.; Bigeard, E.; Gallet, B.; Gachenot, M.; Le Panse, S.; Jauzein, C.; Le Gac, M.; Decelle, J.; Pohnert, G.; Vallet, M.; Talman, A. M.; Guillou, L.
10.1101/2025.04.10.648098 — microbiology — Posted on 2025-04-10
3366 Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia
Chen, Y.-T.; Liu, Z.; Fucich, D.; Giulieri, S. G.; Liu, Z.; Wadhwa, R.; Rios, G.; Henschel, H.; Tyagi, N.; Olivier, F. A. B.; Monk, I. R.; Shah, S. S.; Sridhar, S. H.; Drikic, M.; Bianco, C.; Lohia, G. K.; Beg, A. Z.; Planet, P. J.; Lewis, I. A.; Sebra, R.; Traven, A.; Hachani, A.; Stinear, T. P.; Howden, B.; Boyd, J.; Riquelme, S. A.; Wang, C.; Prince, A. S.; Wong, T.
10.1101/2025.04.10.647998 — microbiology — Posted on 2025-04-10
3370 TIR immune signaling is blocked by phosphorylation to maintain plant growth
Li, J.; Chen, S.; Yu, B.; Li, Q.; Liu, R.; Wang, Z.; Wan, L.; Zhao, Y.
10.1101/2025.04.09.647920 — plant biology — Posted on 2025-04-10
3371 Functional MRI Signatures of Autonomic Physiology in Aging
Fan, J.; Juttukonda, M. R.; Goodale, S. E.; Wang, S.; Orban, C.; Varadarajan, D.; Polimeni, J. R.; Chang, C.; Salat, D. H.; Chen, J. E.
10.1101/2025.04.05.647057 — physiology — Posted on 2025-04-10
3372 Active and Probe-Free Intracellular Rheology via Phase-Sensitive Thermoviscous Flows
Stoev, I. D.; Bolger-Munro, M.; Minopoli, A.; Wagner, S.; Krishnaswamy, V. R.; Erben, E.; Weissenbruch, K.; Maghelli, N.; Bastmeyer, M.; Heisenberg, C.-P.; Kreysing, M.
10.1101/2025.04.07.647540 — biophysics — Posted on 2025-04-10
3374 Temperature and Excipient Mediated Modulation of Monoclonal Antibody Interactions Revealed by kD, Rheology, and Raman Spectroscopy
Eskens, O. N.; Virk, S. S.; Virk, A. S.; Venkataramani, D.; Crames, M.; Vaca, M. C.; Matusewicz, M.; Smith, C.; George, J.; Taylor, C.; Marlow, M. S.; Amin, S.
10.1101/2025.04.06.646989 — biophysics — Posted on 2025-04-10
3375 Atomic Conformational Dynamics and Actin-Crosslinking Function of Alpha-Actinin Revealed by SimHS-AFMfit
Ngo, K. X.; Sumikama, T.; Vuillemot, R.; Nguyen, H. G.; Uyeda, T.; Le, N. T. P.; Grudinin, S.
10.1101/2025.04.06.647477 — biophysics — Posted on 2025-04-10
3379 Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase
Violante, S.; Kyaw, A.; Kouatli, L.; Paladugu, K.; Apostolakis, L.; Jenks, M.; Johnson, A.; Sheldon, R.; Schilmiller, A.; Visconti, P.; Cross, J.; Levin, L.; Buck, J.; Balbach, M.
10.1101/2025.04.09.647926 — biochemistry — Posted on 2025-04-10
3380 Gut sulfide metabolism modulates behavior and brain bioenergetics
Kumar, R.; Sykes, D. J.; Band, V. I.; Schaller, M. L.; Patel, R.; Vitvitsky, V.; Sajjakulnukit, P.; Singhal, R.; Wong, H. K. A.; Hourigan, S. K.; Ichinose, F.; Lyssiotis, C. A.; Shah, Y. M.; Banerjee, R.
10.1101/2025.04.09.647962 — biochemistry — Posted on 2025-04-10
3382 Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W.; Yim, J.; Tischer, D.; Salike, S.; Woodbury, S.; Kim, D.; Kalvet, I.; Kipnis, Y.; Coventry, B.; Altae-Tran, H.; Bauer, M.; Barzilay, R.; Jaakkola, T.; Krishna, R.; Baker, D. A.
10.1101/2025.04.09.648075 — biochemistry — Posted on 2025-04-10
3383 Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Chudzik, K.; Sato, Y.; Yan, X.; Ullrich, S.; Trakarnphornsombat, W.; Schermelleh, L.; Fudenberg, G.; Kimura, H.; Robson, M. I.; Solovei, I.
10.1101/2025.04.09.648027 — cell biology — Posted on 2025-04-10
3384 Protein diffusion controls how single cells respond to electric fields
Nwogbaga, I.; Belliveau, N. M.; Singh, A. R.; Sun, D.; Mulenga, N.; Theriot, J. A.; Camley, B. A.
10.1101/2025.04.09.647627 — cell biology — Posted on 2025-04-10
3385 Tunable 3D Alveolosphere Model from Human Alveolar Cells: A Breakthrough Tool to Explore Emphysema Pathophysiology
Guecamburu, M.; Pavot, A.; Jeanniere, c.; belaroussi, y.; Thumerel, M.; sammaniego, e.; begueret, H.; maucort, g.; decoeur, f.; Dupuy, J.-W.; raymond, a.-a.; esteves, P.; Grassion, L.; dournes, G.; berger, p.; maurat, e.; latouille, e.; Studer, V.; Dupin, I.; henrot, P.; zysman, m.
10.1101/2025.04.09.645486 — cell biology — Posted on 2025-04-10
3387 Identification of novel candidate regulators of human naive pluripotency by means of a genetic switch utilizing the chimeric receptor G-CSFR:GP130
Kiani, T.; Santamaria, C.; Kafousi, A.; Doerflinger, N.; Rognard, C.; Bender, A.; Dumas, M.; Weber, M.; Bruneau, A.; David, L.; Savatier, P.; Bourillot, P.-Y.
10.1101/2025.04.09.647577 — cell biology — Posted on 2025-04-10
3388 Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury
Tu, R.; Zheng, H.; Zheng, B.; Zhong, Q.; Qian, J.; Wu, F.; Shiokawa, T.; Ochiai, Y.; Kobayashi, H.; Waterbury, Q. T.; Zamechek, L. B.; Takahashi, S.; Mizuno, S.; Huang, C.; Li, P.; Hayakawa, Y.; Wang, T. C.
10.1101/2025.04.09.647847 — cell biology — Posted on 2025-04-10
3389 A Multimodal Imaging Pipeline for the Discovery of Molecular Markers of Cellular Neighborhoods
Pham, T.; Farrow, M. A.; Migas, L. G.; Dufresne, M.; Colley, M. E.; Allen, J. L.; de Caestecker, M.; Van de Plas, R.; Spraggins, J. M.
10.1101/2025.04.07.647675 — molecular biology — Posted on 2025-04-10
3393 Mechanisms controlling the plasma membrane targeting and the nanodomain organization of the plant SPFH protein HIR2
Danek, M.; Hdedeh, O.; Boutet, J.; Safi, H.; Abuzeineh, A.; Martin Barranco, A.; Fiche, J.-B.; Mercier, C.; Nollmann, M.; BOUTTE, Y.; Santoni, V.; MONGRAND, S.; Martiniere, A.; Zelazny, E.
10.1101/2025.04.10.648198 — plant biology — Posted on 2025-04-10
3394 CEPR2 perceives group II CEPs to regulate cell surface immunity in Arabidopsis
Rzemieniewski, J.; Zecua-Ramirez, P.; Schade, S.; Camgöz, Z.; Haljiti, G.; Kaur, S.; Ludwig, C.; Hückelhoven, R.; Stegmann, M.
10.1101/2025.04.10.648145 — plant biology — Posted on 2025-04-10
3399 SISE, free LabView-based software for ion flux measurements
Ahmad, N.; Tennakoon, K.; Hedrich, R.; Huang, S.; Roelfsema, R.
10.1101/2025.04.09.647937 — biophysics — Posted on 2025-04-10
3400 The ribosome directs nascent chains through two folding-dependent pathways
Mitropoulou, A. N.; Wlodarski, T. N.; Streit, J. O.; Chan, S. H. S.; Plessa, E.; Woodburn, L. F.; Cabrita, L. D.; Christodoulou, J.
10.1101/2025.04.08.647855 — biophysics — Posted on 2025-04-10
3407 Label-free droplet image analysis with Cellprofiler
Kacsor, D.; Saar-Abroi, M.; Olman, T.; Bartkova, S.; Scheler, O.
10.1101/2025.04.04.647160 — bioinformatics — Posted on 2025-04-10
3408 Impact of Long-Term Mercury Contamination on the Rhizosphere Microbiota of Lotus tenuis: A Pathway to Resilience via Interkingdom Facilitation
Tiodar, E. D.; Vacar, C. L.; Grimm, M. C.; Ganea, I. V.; Balazs, Z. R.; Abrudan, A. M.; Timar, C.; Tantau, I.; Banciu, M.; Angel, R.; Podar, D.
10.1101/2025.04.07.647525 — ecology — Posted on 2025-04-10
3411 Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium
McCabe, M.; Groves, H. E.; Getty, E.; Campbell, E.; Bamford, C. G. G.; Lopez Campos, G.; Shields, M. D.; Power, U. F.
10.1101/2025.04.08.647778 — microbiology — Posted on 2025-04-10
3412 Langerhans Cells Regulate Tongue Intraepithelial Innervation in a Microbiota- and Age-Dependent Manner
Netanely, Y.; Saba, Y.; Naamneh, R.; Yacoub, S.; Jaber, Y.; Raviv, A.; Eli-Berchoer, L.; Shapiro, H.; Elinav, E.; Wilensky, A.; Clausen, B. E.; Hovav, A.-H.
10.1101/2025.04.03.647024 — immunology — Posted on 2025-04-10
3418 VP-CLEM-Kit: An accessible pipeline for visual proteomics using super resolution volume correlative light and electron microscopy (SR-vCLEM)
Lumkwana, D.; Lightley, J.; Vesga, A. G.; de Folter, J.; Domart, M.-C.; Maclachlan, C.; Kumar, S.; Evans, J. R.; Peddie, C.; Burrell, A.; Yoshimura, A.; Mangali, A.; Vahrjmeijer, N.; Bhaga, M.; Smit, C.; Titze, B.; Horrocks, M. H.; Cobra Straker, L.; Garcia, E.; Jones, M. L.; Mclean, A.; Roufosse, C.; Loos, B.; Gandhi, S.; Strange, A.; Henriques, R.; French, P. M.; Collinson, L.
10.1101/2025.04.08.647770 — cell biology — Posted on 2025-04-10
3419 Small non-coding RNAs encapsulating mammalian cells fuel innate immunity
hu, l.; Jiang, X.; Xu, C.; Yang, E.; Xu, D.; Peng, Y.; Han, X.; Si, J.; Shao, Q.; Liu, Z.; Chen, Q.; He, W.; He, S.; Xu, Y.; He, C.; Huang, X.
10.1101/2025.04.07.647669 — molecular biology — Posted on 2025-04-10
3420 Characterization of a Novel FKS1 Mutation in Candida lusitaniae Shows a Potential Critical Role for MKC1 in Echinocandin Resistance
Accoceberry, I.; Lefranc, M.; meunier, C.; Quiles, F.; Kordalewska, M.; Biteau, N.; Perlin, D. S.; El Kirat Chatel, S.; Noël, T.
10.1101/2025.04.08.647726 — microbiology — Posted on 2025-04-10
3421 Coumarins disrupt cell-cell communication for control of pathogenesis and virulence in ESKAPEEs and fungal opportunists
Boon, D.; O'Rourke, B.; Carmody, M.; Woods, D. F.; Gloe, A.; Platero-Rochart, D.; Sanchez-Murcia, P. A.; McGlacken, G.; Reen, F. J.
10.1101/2025.04.09.647955 — microbiology — Posted on 2025-04-10
3422 Single-cell SNP-DNA sequencing precisely maps genotoxic events in CRISPR-edited primary cells
Boutin, J.; FAYET, S.; MARIN, V.; BERGES, C.; Riandiere, M.; Toutain, J.; Lamrissi-Garcia, I.; THIBAULT, C.; Cappellen, d.; Dabernat, S.; Poulet, A.; Francilette, M.; DROUIN, N.; MOREAU-GAUDRY, F.; BEDEL, A.
10.1101/2025.04.04.647179 — bioengineering — Posted on 2025-04-10
3424 A national assessment of waterbird hunting in coastal wetlands of Suriname, south America
Mizrahi, D. S.; Spaans, A. L.; Spaans-Scheen, M. J.; Cox, A. R.; Laliberte, B.; Gallo-Cajiao, E.; Roy, C.
10.1101/2025.04.04.646930 — ecology — Posted on 2025-04-10
3425 Contributions of T helper 9 cells in endometriosis-associated inflammation and lesion growth
McCallion, A.; Zutautas, K.; Sisnett, D.; Yolmo, P.; Lingegowda, H.; Ravishanker, A.; Hoang, D. V.; Tayade, C.
10.1101/2025.04.04.647212 — immunology — Posted on 2025-04-10
3426 Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes
Young, M.; Aastrup, M.; Patel, N.; Cullen, F.; Hansen, E. S. S.; Clark, J. E.; Eykyn, T. R.; Vaeggemose, M.; Vujic, A.; Karatzia, L.; Valkovic, L.; Miller, J. J. J. J.; Buus, N. H.; Laustsen, C.; Yaqoob, M. M.; Aksentijevic, D.
10.1101/2024.10.24.620055 — physiology — Posted on 2025-04-10
3427 Cold-activated hepatocyte derived exosomes promote BAT thermogenesis through miR-293-5p
Gao, X.; Xu, J.; Xu, Z. q.; Jiang, M.; Zhu, J.; Geng, Y.; Dong, S.; Zhou, Z.; Li, Y. n.; Xu, Y. J.
10.1101/2025.04.04.647213 — genetics — Posted on 2025-04-10
3431 Dopamine and temporal discounting: revisiting pharmacology and individual differences
Smith, E.; Theis, H.; van Eimeren, T.; Knauth, K.; Tuzsus, D.; Zhang, L.; Mathar, D.; Peters, J.
10.1101/2024.08.28.610170 — neuroscience — Posted on 2025-04-10
3434 Reduced glutathione levels in Enterococcus faecalis trigger metabolic and transcriptional compensatory adjustments during iron exposure.
Aliaga-Tobar, V. M.; Torres, J.; Mendoza, S.; Galvez, G.; Ortega, J.; Gomez, S.; Parra, V.; Arenas, F.; Maass, A. E.; Siegel, A.; Gonzalez, M.; Latorre, M. A.
10.1101/2025.04.04.647250 — systems biology — Posted on 2025-04-10
3435 Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesis
Yang, Y.; Shi, J.; Yang, Y.; Liu, S.; Li, Y.; Feng, L.; Yan, R.; Yao, J.; Chen, L.; Ding, L.; Zhang, Z.; Feng, H.; Chen, H.; Lu, Q.; Yan, T.; Yan, Z.; Chandrakesan, P.; Qu, D.; Du, J.; Cao, Z.; Peng, J.; Weygant, N.
10.1101/2025.04.03.646911 — cancer biology — Posted on 2025-04-10
3436 Exploring Mechanisms of Early Acquired Resistance to Doxorubicin in Melanoma in 3D Model
Negrea, G. G.; Balacescu, L.; Pavel, O.; Rauca, V.; Dume, B.; Licarete, E.; Patras, L.; Banciu, M.; Sesarman, A.
10.1101/2025.04.07.646990 — cancer biology — Posted on 2025-04-10
3438 ReScale4DL: Balancing Pixel and Contextual Information for Enhanced Bioimage Segmentation
Ferreira, M. G.; Saraiva, B. M.; Brito, A. D.; Pinho, M. G.; Henriques, R.; Gomez-de-Mariscal, E.
10.1101/2025.04.09.647871 — biophysics — Posted on 2025-04-10
3439 Mechanical properties of adherent cell sheets analyzed by deflection of supporting membrane
Efremov, Y. M.; Subbot, A. M.; Novikov, I. A.; Avetisov, S. E.; Timashev, P. S.
10.1101/2025.04.03.647015 — biophysics — Posted on 2025-04-10
3445 A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum
Christensen, J. B.; Donovan, A. P. A.; Moradi, M.; Vanacore, G.; Helmy, M.; Reid, A. J.; Lee, J. T. H.; Bayraktar, O. A.; Brand, A. H.; Bayin, N. S.
10.1101/2025.04.10.648162 — developmental biology — Posted on 2025-04-10
3446 Parkinson's Disease-Linked Kir4.2 Mutation R28C Leads to Loss of Ion Channel Function
Chen, X.; Finol-Urdaneta, R. K.; Chen, M.; Sykes, A.; Gao, B.; Adams, D. J.; Mellick, G. D.; Ma, L.
10.1101/2024.05.05.592599 — cell biology — Posted on 2025-04-10
3448 Pro-neurogenic potential of blood cells cultured in autologous plasma
Arora, R.; Bhardwaj, A.; Panda, N. K.; Das, R.; Sinharay, S.; Patkulkar, P.; Gupta, T.; Bakshi, J.; Virk, R.; Nayak, G.; Patro, S. K.; Bhadada, S.; Pal, A.; Pal, R.; Chhabra, S.; Chhabra, S.; Pal, M.; Rashid, S.; SHARMA, M.
10.1101/2025.03.19.643269 — cell biology — Posted on 2025-04-10
3449 Spatial Analysis of Placentae During Congenital Cytomegalovirus Infection Reveals Distinct Cellular Profiles in Immune Cells and Trophoblasts
Sintim-Aboagye, E.; Quach, H. Q.; Sherman, W.; Farnan, S.; Otrubova, K.; Verma, N.; Littlefield, D.; Punia, S.; Johnson, E.; Blackstad, M.; Schleiss, M.; Norgan, A.; Gray, C.; Enninga, E. A. L.; Chakraborty, R.
10.1101/2025.04.04.647170 — immunology — Posted on 2025-04-10
3451 Trends in Self-citation Rates in High-impact Neurology, Neuroscience, and Psychiatry Journals
Rosenblatt, M.; Mehta, S.; Peterson, H.; Dadashkarimi, J.; Rodriguez, R. X.; Foster, M. L.; Adkinson, B. D.; Liang, Q.; Kimble, V. M.; Ye, J.; McCusker, M. C.; Farruggia, M. C.; Rolison, M.; Westwater, M. L.; Jiang, R.; Noble, S.; Scheinost, D.
10.1101/2022.09.27.509533 — neuroscience — Posted on 2025-04-10
3453 Vesicle-mediated oxytocin release drives melanocortin circuit maturation during a neonatal critical period
Barelle, P.-Y.; Schaller, F.; Park, S.; Caron, E.; Klucznik, J.; Ciofi, P.; Muscatelli, F.; Bouret, S. G.
10.1101/2025.04.10.648134 — neuroscience — Posted on 2025-04-10
3454 Transcription factor LHX2 suppresses astrocyte proliferation in the postnatal mammalian cerebral cortex
Iyer, A.; Fronteiro, R.; Bhatia, P.; Kumari, S.; Singh, A.; Zhou, J.; Bocchi, R.; Narayanan, R.; Tole, S.
10.1101/2025.04.10.648067 — neuroscience — Posted on 2025-04-10
3457 Noradrenergic-dependent restoration of visual discrimination in a mouse model of SYNGAP1-related disorder
Katsanevaki, D.; Dupuy, N.; Booker, S. A.; Wright, D.; Kenny, A.; Chen, Z.; Kudryashova, N.; Howitt, P.; Stanfield, A. C.; Kind, P. C.; Rochefort, N. L.
10.1101/2025.04.09.647923 — neuroscience — Posted on 2025-04-10
3459 Lateral Hypothalamic Glutamate and GABA Neurons Cooperatively Shape Striatum-Wide Dopamine Dynamics During Consumption
Gordon-Fennell, A.; Benowitz, B. M.; Barbakh, J. M.; Montequin, I.; Campuzano, A.; Stevenson, H. P.; Lu, E.; Hjort, M. M.; Ancell, E.; Critz, M.; Witten, D.; Stuber, G.
10.1101/2025.04.09.648052 — neuroscience — Posted on 2025-04-10
3460 Divalent siRNA for prion disease
Gentile, J. E.; Corridon, T. L.; Serack, F. E.; Echeverria, D.; Kennedy, Z. E.; Gallant-Behm, C. L.; Hassler, M. R.; Kinberger, G.; Kamath, N. G.; Lian, Y.; Gross, K. Y.; Miller, R.; DeSouza-Lenz, K.; Howard, M.; Guzman, K.; Chan, N.; Laversenne, V.; Curtis, D. T.; Fettes, K.; Lemaitre, M.; Cappon, G.; Jackson, A. L.; Yamada, K.; Alterman, J. F.; Coffey, A. A.; Minikel, E. V.; Khvorova, A.; Vallabh, S. M.
10.1101/2024.12.05.627039 — neuroscience — Posted on 2025-04-10
3462 Exploiting Pseudomonas syringae Type 3 secretion to study effector contribution to disease in spinach
Mendel, M.; Zuijdgeest, X.; Berg, F. v. d.; Meer, L. v. d.; Elberse, J.; Skiadas, P.; Seidl, M.; Ackerveken, G. v. d.; Jonge, R. d.
10.1101/2024.06.14.599008 — plant biology — Posted on 2025-04-10
3463 Immune cells employ intermittent integrin-mediated traction forces for 3D migration
Czerwinski, T.; Bischof, L.; Böhringer, D.; Kara, S.; Strissel, P. L.; Strick, R.; Winterl, A.; Gerum, R.; Wittmann, E.; Schneider, M.; Beckmann, M. W.; Nusser, G.; Wiesinger, M.; Budday, S.; Lux, A.; Voskens, C.; Fabry, B.; Mark, C.
10.1101/2023.04.20.537658 — biophysics — Posted on 2025-04-10
3464 Bridging data gaps: predicting inadequate micronutrient intake with machine learning
Voukelatou, V.; Tang, K.; Lauzana, I.; Jangid, M.; Martini, G.; de Pee, S.; Knight, F.; Piovani, D.
10.1101/2025.04.08.647715 — bioinformatics — Posted on 2025-04-10
3466 Structural analysis of tilvestamab in complex with AXL
Christakou, E.; Lopez, A. J.; Muruganandam, G.; Micklem, D.; Lorens, J. B.; Kursula, P.
10.1101/2024.12.04.626834 — biochemistry — Posted on 2025-04-10
3468 Genomic prediction of stalk lodging resistance and the associated intermediate phenotypes in maize using whole-genome resequence and multi-environmental data
Machado e Silva, C.; Kunduru, B.; Bokros, N.; Tabaracci, K.; Oduntan, Y.; Brar, M. S.; Kumar, R.; Stubbs, C. J.; Nardino, M.; McMahan, C. S.; DeBolt, S.; Robertson, D. J.; Sekhon, R. S.; Morota, G.
10.1101/2025.04.06.647466 — genetics — Posted on 2025-04-10
3469 EnviroAmpDesigner, a tool for designing high specificity multiplex PCR primer panels for detecting and subtyping a target organism in environmental surveillance samples
Spadar, A.; Mahindroo, J.; Troman, C.; Owusu, M.; Abu-Sarkodie, Y.; Owusu-Dabo, E.; Abraham, D.; Benny, B.; Govindan, K.; Mohan, V. R.; Dyson, Z. A.; Grassly, N.; Holt, K. E.
10.1101/2025.04.10.648097 — bioinformatics — Posted on 2025-04-10
3470 OBE-DB: A Computational Tool and Web Server for the Prediction of Antiobesity Drugs
Murcia-Garcia, E.; Martinez-Cortes, C.; Banegas-Luna, A. J.; Hernandez-Morante, J. J.; Perez-Sanchez, H.
10.1101/2025.04.10.648110 — bioinformatics — Posted on 2025-04-10
3471 Two telomere-to-telomere, gap-free genome assemblies and comparisons revealed the conserved key genes associated with sugar accumulation in Rubus genus
Li, X.; Han, X.; Liu, S.; Zhang, Q.; Guan, J.; Tang, Y.; Zhang, M.; Lian, H.; Xu, P.; Zheng, M.; Li, K.; Sun, G.; Sun, Y.; Dong, Y.; Lin, X.; Liang, Y.; Wang, Z.; Qin, G.; Li, B.; Zhou, H.; Yang, G.; Liu, Z.; He, H.; Zhou, J.
10.1101/2025.04.09.646780 — genomics — Posted on 2025-04-10
3473 Aevol-9: A simulation platform to decipher the evolution of genome architecture
Luiselli, J.; Parsons, D.; Galle, R.; Banse, P.; Rouzaud-Cornabas, J.; Beslon, G.
10.1101/2025.04.10.648095 — evolutionary biology — Posted on 2025-04-10
3475 Impact of Single Freeze-Thaw Cycles on Serum Protein Stability: Implications for Clinical Biomarker Validation Using Mass Spectrometry
Sauer, T.; Oberländer, M.; Maushagen, R.; Radloff, H.; Braun, R.; Honselmann, K.; Wellner, U.; Habermann, J.; Benecke, C.; Keck, T.; Gemoll, T.
10.1101/2025.04.09.647925 — molecular biology — Posted on 2025-04-10
3480 The protease interpain A of Prevotella intermedia promotes human oral squamous cell carcinoma cells proliferation and migration
Chang, S.-M.; Huang, I.-H.; Ciou, Y.-J.; Wang, W.-R.; Wu, N.-H.; Chuu, C.-P.; Hsiao, J.-R.; Chang, J. S.; Chang, J.-Y.; Chen, J.-W.
10.1101/2024.10.20.619282 — cancer biology — Posted on 2025-04-10
3481 H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma
Shamekhi, T.; Zeng, B.; Sun, C. X.; Daniel, P.; Lim Kam Sian, T. C. C.; Goncalves, G.; Huang, G.; Fahimi, F.; Selvakumar, N.; Tanuwidjaya, E.; Woodhouse, I.; Kritzer, B.; Schittenhelm, R. B.; Mazzieri, R.; Cain, J. E.; Nazarin, J.; Hansford, J. R.; Firestein, R.; Dolcetti, R.; Faridi, P.
10.1101/2025.04.07.647502 — cancer biology — Posted on 2025-04-10
3485 ST-FFPE-mIF: Integrating Spatial Transcriptomics and Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tissues Using Stereo-seq
Zhang, X.; Zhang, M.; Xu, Y.; Song, Y.; Yang, X.; Wu, Y.; Zhao, X.; Ran, D.; Liu, X.; Huang, H.; Lei, W.; Li, H.; Zhang, Y.; Xi, F.; Li, G.; Liu, X.; Xu, L.; Chen, A.; Liao, S.; Zhang, J. j.
10.1101/2025.01.24.634655 — biochemistry — Posted on 2025-04-10
3489 IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
Plattner, C.; Sturm, G.; Kuehl, A. A.; Atreya, R.; Carollo, S.; Gronauer, R.; Rieder, D.; Guenther, M.; Ormanns, S.; Manzl, C.; Wirtz, S.; Meneghetti, A. R.; Hegazy, A.; Patankar, J. V.; Carrero, Z. I.; TRR241 IBDome Consortium, ; Neurath, M. F.; Kather, J. N.; Becker, C.; Siegmund, B.; Trajanoski, Z.
10.1101/2025.03.26.645544 — molecular biology — Posted on 2025-04-10
3491 Ternary Neurexin-T178-PTPR complexes represent a presynaptic core-module of neuronal synapse organization
Thivaios, S.; Schwenk, J.; Brechet, A.; Boudkkazi, S.; Sethumadhavan, N.; Henneken, P.; Miura, E.; Hayashi, A.; Kocylowski, M. K.; Haupt, A.; Kaminski, D.; Schreiner, D.; van den Broucke, J.-B.; Kulik, A.; Schulte, U.; Sterky, F. H.; Yuzaki, M.; Scheiffele, P.; Fakler, B.
10.1101/2024.07.16.603715 — neuroscience — Posted on 2025-04-10
3494 Deficient Memory, Long-Term Potentiation and Hippocampal Synaptic Plasticity in Galectin-4-Deficient Mice
Brocca, M. E.; Mora-Rubio, A.; Alonso-Calvino, E.; Fernandez-Lopez, E.; Diez-Revuelta, N.; Guirado-Calatrava, J. C.; Alvarez-Velez, R.; Dopazo, A.; Lopez-Merino, E.; Martos-Punal, D.; Esteban, J. A.; Aguilar, J.; Higuero, A. M.; Abad-Rodriguez, J.
10.1101/2024.10.14.617868 — neuroscience — Posted on 2025-04-10
3498 ERK and PKA signaling drive the evolutionary expansion of the cortex
Zhang, Z.; Xu, Z.; Fu, T.; Li, J.; Yang, F.; Yang, C.; Zheng, W.; Sha, Z.; Gao, Y.; Sun, M.; Li, Z.; Ding, J.; LI, X.; Yang, Z.
10.1101/2025.04.09.647935 — developmental biology — Posted on 2025-04-09
3499 Epiproteomic control of the epitranscriptome drives cortical neurogenesis
Borisova, E.; Cuthill, K. J.; Dannenberg, R.; Koch, J.; Nowaczyk, J.; Schaub, T.; Schwark, M.; Kastelic, N.; Kupryianchyk-Schultz, I.; Kirchner, M.; Pentimalli, T. M.; Fokkens, T. J.; Stein, F.; Dietrich, C.; Quedenau, C.; Borodina, T.; Schwefel, D.; Conrad, T.; Rybak-Wolf, A.; Rajewsky, N.; Mertins, P.; Haberkant, P.; Lorenz, S.; Brose, N.; Kawabe, H.; Tarabykin, V.; Ambrozkiewicz, M. C.
10.1101/2025.04.09.646620 — cell biology — Posted on 2025-04-09
3500 Extracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.
Lombino, F. L.; Shafiq, M.; Matamoros-Angles, A.; Schwarz, J. R.; Gromova, K. V.; Stajano, D.; Siebels, B.; Bergmann, L.; Magnus, T.; Schweizer, M.; Ricklefs, F. L.; Schlueter, H.; Hill, A. F.; Kneussel, M.; Glatzel, M.
10.1101/2025.04.09.647922 — neuroscience — Posted on 2025-04-09
3501 Learning and language in the unconscious human hippocampus
Katlowitz, K. A.; Shah, S.; Franch, M. C.; Adkinson, J.; Belanger, J. L.; Mathura, R. K.; meszena, D.; Mickiewicz, E. A.; McGinley, M.; Munoz, W.; Banks, G. P.; Cash, S. S.; Hsu, C.-W.; Paulk, A. C.; Provenza, N. R.; Watrous, A.; Williams, Z.; Heilbronner, S. R.; Kim, R.; Rungratsameetaweemana, N.; Hayden, B. Y.; Sheth, S. A.
10.1101/2025.04.09.648012 — neuroscience — Posted on 2025-04-09
3502 Reward influences movement vigor through multiple motor cortical mechanisms
Smoulder, A. L.; Marino, P. J.; Oby, E. R.; Snyder, S. E.; Batista, A. P.; Chase, S. M.
10.1101/2025.04.09.648001 — neuroscience — Posted on 2025-04-09
3503 Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair
Silver, S. E.; Howells, A. R.; Arhontoulis, D. C.; Randolph, L. N.; Hyams, N. A.; Barrs, R. W.; Li, M.; Kerr, C. M.; Robino, R. A.; Morningstar, J. E.; Bain, J. D.; Floy, M. E.; Norris, R. A.; Bao, X.; Ruddy, J. M.; Palecek, S. P.; Ferreira, L. M. R.; Lian, X. L.; Mei, Y.
10.1101/2025.04.09.648007 — bioengineering — Posted on 2025-04-09
3504 Predictive Ability of Enviromic Modeling in GxE Interactions for Upland Rice Site Recommendations
Bahia, M. A. M.; Marcatti, G. E.; Breseghello, F.; Melo, P. G. S.; Dias, K. O. G.; Xu, Y.; Resende, R. T.
10.1101/2025.04.05.647387 — genetics — Posted on 2025-04-09
3507 Single-cell phylogenomics identifies major groups of marine eugregarine parasites (Apicomplexa)
Park, E.; Na, I.; Closs, A.; Hall, K.; Froese, T.; Currie-Olsen, D.; Pontier, O.; Van Steenkiste, N.; Keeling, P. J.; Leander, B. S.
10.1101/2025.04.08.647885 — microbiology — Posted on 2025-04-09
3509 Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autism
Papendorp, C. M.; Nolan, E.; Higashimori, H.; Jhanji, M.; Goicouria, L.; Pieplow, C.; Whitley, K.; Defreitas, S.; Elacio, J.; Nie, D.; Kavanaugh, B.; Best, C. R.; Lizarraga, S. B.; Liu, J. S.-H.
10.1101/2025.02.21.639570 — neuroscience — Posted on 2025-04-09
3510 Intestinal fructose metabolism/GLP-1/β-cell axis counteracts hyperglycemia after short-term fructose ingestion
Murao, N.; Seino, Y.; Morikawa, R.; Hidaka, S.; Haraguchi, T.; Tomatsu, E.; Habara, M.; Ohno, T.; Yokoi, N.; Harada, N.; Hayashi, Y.; Yamada, Y.; Suzuki, A.
10.1101/2025.04.01.646509 — physiology — Posted on 2025-04-09
3511 An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics
Yu, S.; Michon, M.; Lingappa, A. F.; Paulvannan, K.; Solas, D.; Staats, K. A.; Ichida, J.; Dey, D.; Rosenfeld, J.; Lingappa, V. R.
10.1101/2024.03.28.587289 — physiology — Posted on 2025-04-09
3513 The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data
Zhang, S.; Chen, X.; Jin, E.; Wang, A.; Chen, T.; Zhang, X.; Zhu, J.; Dong, L.; Sun, Y.; Yu, C.; Zhou, Y.; Fan, Z.; Chen, H.; Zhai, S.; Sun, Y.; Chen, Q.; Xiao, J.; Song, S.; Zhang, Z.; Bao, Y.; Wang, Y.; Zhao, W.
10.1101/2025.03.31.646270 — genomics — Posted on 2025-04-09
3514 Capturing Natural Evolution in Function-guided RNA Design via Genomic Foundation Models
Zheng, S.; Huang, Y.; Zhang, B.; Chen, X. J.; Ma, R.; Zhang, Z.; Chen, X.; Yang, Y.
10.1101/2025.04.08.647793 — evolutionary biology — Posted on 2025-04-09
3515 Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition
Johnson, K. A.; Jones, F. K.; Ghadiali, R. S.; Lee, G.; Luke, T.-H. A.; Sweeney, M. D.; Moffitt, R. A.; Mamchaoui, K.; Ricci, E.; Young, I.; Pisconti, A.
10.1101/2025.02.26.640472 — cell biology — Posted on 2025-04-09
3516 Lock, Protect, and Bind: In Vitro Selection of LNA-modified Aptamers Using a Mutant T7 RNA Polymerase
Neis, K.; Civit, L.; Pedersen, K.; Schachtner, M.; Wengel, J.; Wagner, R.; Thiel, S.; Kjems, J.; Valero, J.
10.1101/2025.04.09.647959 — molecular biology — Posted on 2025-04-09
3518 Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium
Hu, L. Z.; Hirschhorn, T.; Douglass, E.; Murray, D.; Trudeau, S. J.; Turunen, M.; Pampou, S.; Grunn, A.; Realubit, R.; Antolin, A. A.; Wang, A. L. E.; Li, H.; Subramaniam, P.; Karan, C.; Alvarez, M.; Honig, B.; Stockwell, B. R.; Califano, A.
10.1101/2023.10.08.561457 — systems biology — Posted on 2025-04-09
3519 Specialized Pro-Resolving Mediator loaded Extracellular Vesicles Mitigate Pulmonary Inflammation
Karpurapu, M.; Yan, J.; Chung, S.; PANNU, S.; Parinandi, N.; Zhang, L.; Berdyshev, E.; Christman, J. W.
10.1101/2025.04.09.648009 — synthetic biology — Posted on 2025-04-09
3521 Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy
Reever, C. M.; Boscia, A. R.; Deutsch, T. C. J.; Patel, M. P.; Miralles, R. M.; Kittur, S.; Fleischel, E. J.; Buo, A. M. L.; Yorek, M. S.; Meisler, M. H.; Farber, C. R.; Patel, M. K.
10.1101/2025.04.09.647983 — bioengineering — Posted on 2025-04-09
3523 Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells
Nemkov, T.; Stauffer, E.; Cendali, F.; Stephenson, D.; Nader, E.; Robert, M.; Skinner, S.; Dzieciatkowska, M.; Hansen, K. C.; Robach, P.; Millet, G.; Connes, P.; D'Alessandro, A.
10.1101/2025.04.09.648006 — biochemistry — Posted on 2025-04-09
3528 The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity
Mouillet, J.-F.; Ouyang, Y.; Sadovsky, E.; Kothandan, V. K.; Sorenson, H. L.; Badeau, L. J.; Sarkar, S. N.; Chu, T.; Sorkin, A.; Sadovsky, Y.
10.1101/2025.04.03.647038 — developmental biology — Posted on 2025-04-09
3529 Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs
Whittaker, M. N.; Brooks, D. L.; Quigley, A.; Jindal, I.; Said, H.; Qu, P.; Wang, J. Z.; Levine, M. A.; Ahrens-Nicklas, R. C.; Musunuru, K.; Alameh, M.-G.; Peranteau, W. H.; Wang, X.
10.1101/2024.04.22.590531 — molecular biology — Posted on 2025-04-09
3534 Segmented filamentous bacteria undergo a structural transition at their adhesive tip during unicellular to filament development
Cruz, A. R.; Wimmer, B. H.; Teo, T.-H.; Pehau-Arnaudet, G.; Winter, J.-M.; Gazi, A.; Lafaye, P.; Brier, S.; Legrand, A.; Dubrovsky-Gaupp, A.; Berard, M.; Ayme, G.; Sartori-Rupp, A.; Medalia, O.; Schnupf, P.
10.1101/2025.04.09.647586 — microbiology — Posted on 2025-04-09
3535 Bactofilins are essential spatial organizers of peptidoglycan insertion in the Lyme disease spirochete Borrelia burgdorferi
Zinck, C. B.; Carracoi, V.; Kloos, Z. A.; Wachter, J.; Schwartz, C.; Stewart, P. E.; Jacobs-Wagner, C.; Rosa, P. A.; Takacs, C. N.
10.1101/2025.04.09.647816 — microbiology — Posted on 2025-04-09
3536 Caffeine induces age-dependent increases in brain complexity and criticality during sleep
Thölke, P.; Arcand-Lavigne, M.; Lajnef, T.; Frenette, S.; Carrier, J.; Jerbi, K.
10.1101/2024.05.27.596056 — neuroscience — Posted on 2025-04-09
3538 TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia
Schurer, A.; Ilyas, H.; Maron, M. I.; Hegde, S.; Leyden, M. R.; Roy, I.; Hyka, R.; Dada, L.; Shabanowitz, J.; Hunt, D.; Angeles, E.; Morell, V.; Lorton, B. M.; Glushakow-Smith, S.; Borger, D. K.; Wang, Y.; Miles, L. A.; Belizaire, R.; Kitamura, S.; Gritsman, K.; Shechter, D.
10.1101/2025.04.07.647605 — cancer biology — Posted on 2025-04-09
3539 Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence
Piyadasa, H.; Oberlton, B.; Ribi, M.; Ranek, J. S.; Averbukh, I.; Leow, K.; Amouzgar, M.; Liu, C. C.; Greenwald, N. F.; McCaffrey, E. F.; Kumar, R.; Ferrian, S.; Tsai, A. G.; Filiz, F.; Fullaway, C. C.; Bosse, M.; Varra, S. R.; Kong, A.; Sowers, C.; Gephart, M. H.; Nunez-Perez, P.; Yang, E.; Travers, M.; Schachter, M. J.; Liang, S.; Santi, M. R.; Bucktrout, S.; Gherardini, P. F.; Connolly, J.; Cole, K.; Barish, M. E.; Brown, C. E.; Oldridge, D. A.; Drake, R. R.; Phillips, J. J.; Okada, H.; Prins, R.; Bendall, S. C.; Angelo, M.
10.1101/2025.03.12.642624 — cancer biology — Posted on 2025-04-09
3542 MonoAlg3D: Enabling Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU Clusters
Berg, L. A.; Oliveira, R. S.; Camps, J.; Wang, Z. J.; Doste, R.; Bueno-Orovio, A.; dos Santos, R. W.; Rodriguez, B.
10.1101/2025.04.09.647733 — bioengineering — Posted on 2025-04-09
3548 Elucidating Chiral Myosin-Induced Actin Dynamics: From Single Filament Behavior to Collective Structures
Haraguchi, T.; Yoshimura, K.; Inoue, Y.; Imi, T.; Hasegawa, K.; Nagai, T.; Mori, T.; Matsuno, K.; Ito, K.
10.1101/2025.03.26.645581 — cell biology — Posted on 2025-04-09
3551 Complementary killing activities of Pbunavirus LS1 and Bruynoghevirus LUZ24 phages on planktonic and sessile Pseudomonas aeruginosa PAO1 derivatives
Billaud, M.; Plantady, C.; Lerouge, B.; Ollivier, E.; Lossouarn, J.; Moncaut, E.; Deschamps, J.; Briandet, R.; Cleret, A.; Fevre, C.; Demarre, G.; Petit, M.-A.
10.1101/2025.04.09.647956 — microbiology — Posted on 2025-04-09
3554 Identification of Novel Mutations Causing Clofazimine Resistance in Mycobacterium intracellulare
Jiang, X.; Cao, D.; Dong, X.; Xu, P.; Li, Y.; Yuan, X.; Xiang, Y.; Xu, K.; Zhang, Y.
10.1101/2025.04.09.647911 — microbiology — Posted on 2025-04-09
3556 GSK-3 regulates CD4-CD8 cooperation needed to generate super-armed CD8+ cytolytic T cells against tumors
Moes, B.; Janna, J.; Kazanova, A.; LIU, C.; Gao, Y.; Ponnoor, N. A.; Castoun-Puckett, L.; Oroya, A.; Nguyen, H. L.; Cabald, A. L.; Tu, T. H.; Rudd, C. E.
10.1101/2025.03.08.642085 — immunology — Posted on 2025-04-09
3559 Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans AND Non-Human Primates
Conwell, C.; McMahon, E.; Jagadeesh, A.; Vinken, K.; Sharma, S.; Prince, J. S.; Alvarez, G.; Konkle, T.; Livignstone, M.; Isik, L.
10.1101/2025.03.05.641284 — neuroscience — Posted on 2025-04-09
3560 Transient, early, female-specific increase in cortical glial fibrillary acidic protein distribution in the Syrian hamster model of mild peripheral COVID-19
Rahmani Manesh, M.; Wicki-Stordeur, L. E.; York, N. S.; Vendramelli, R.; Warner, B.; Vecchiarelli, H. A.; Ranier-Pope, L.; Khakpour, M.; Bennouna, L. R.; Tremblay, M.-E.; Kobasa, D.; Swayne, L. A.
10.1101/2025.04.08.647811 — neuroscience — Posted on 2025-04-09
3562 Auditory Brainstem Responses in Two Closely Related Peromyscus Species (Peromyscus leucopus and Peromyscus maniculatus)
Joseph, L.; New, E. M.; Joseph, D. M.; Woodley, T. C.; Franco, V. Y.; Li, B.-Z.; Wogan, G. O.; McCullagh, E. A.
10.1101/2024.12.09.627419 — neuroscience — Posted on 2025-04-09
3563 The precision of hippocampal representations predicts incremental value-learning across the adult lifespan
vanGeen, C.; Lempert, K. M.; Cohen, M.; MacNear, K. A.; Reckers, F. M.; Zaneski, L.; Wolk, D.; Kable, J. W.
10.1101/2025.04.08.647815 — neuroscience — Posted on 2025-04-09
3569 NEAR: Neural Embeddings for Amino acid Relationships
Olson, D. R.; Colligan, T.; Demekas, D.; Roddy, J. W.; Youens-Clark, K.; Wheeler, T.
10.1101/2024.01.25.577287 — bioinformatics — Posted on 2025-04-09
3572 Chromosome-level phased genome assembly of the Argan tree Sideroxylon spinosum L.
Mateus, I. B.; Essahibi, A.; Nicholson, P.; Hijri, M.; Qaddoury, A.; Falquet, L.; Reinhardt, D.
10.1101/2025.04.06.647421 — genomics — Posted on 2025-04-09
3573 CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity
Ji, L.; Wang, A.; Sonthalia, S.; Seo, S.; Naiman, D. Q.; Younes, L.; Colantuoni, C.; Geman, D.
10.1101/2023.04.06.535943 — genomics — Posted on 2025-04-09
3576 Multiple evolutionary events in host plant adaptation in Lepidoptera
Luo, M.; Li, B.; Ma, L.; Jia, Z.; Shi, Z.; Liu, H.; Wang, Z.; Zhang, B.; Yu, S.; Qi, J.; Xiao, Y.; Zhou, S.; Chung, H.; Wang, G.
10.1101/2025.04.05.647383 — evolutionary biology — Posted on 2025-04-09
3579 Beta Adrenergic Signaling as a Therapeutic Target for Autoimmunity
Lauten, T. H.; Reed, E. C.; Natour, T.; Pitts, L. J.; Jojo, C. N.; Griffin, B. L.; Case, A. J.
10.1101/2025.04.05.647384 — immunology — Posted on 2025-04-09
3580 Regulation of B cell tolerance and autoimmunity by miR-130b
Herrero-Fernandez, B.; Gonzalez-Molina, M. d. P.; Gamez-Reche, L.; Prieto-Munoz, A. M.; Sanz, J.; Gonzalo, T.; Moreno, A.; Lopez-Molina, M.; Manas, L.; Nemazee, D.; Xiao, C.; Otero-Ortega, L.; Gonzalez-Martin, A.
10.1101/2025.01.22.634242 — immunology — Posted on 2025-04-09
3582 INHBA promotes the progression of gastric cancer by activating MAPK signaling pathway via targeting ITGA6
Zhou, G.; Zhang, R.; Nie, L.; Si, Y.; Liu, T.; Jing, W.; Han, S.; Xuan, M.; Yu, W.; Wang, J.
10.1101/2025.04.05.647266 — cancer biology — Posted on 2025-04-09
3585 Domain shifts in infant brain diffusion MRI: Quantification and mitigation for fODF estimation
Lin, R.; Kebiri, H.; Gholipour, A.; Chen, Y.; Thiran, J.-P.; Karimi, D.; Bach Cuadra, M.
10.1101/2025.04.04.647303 — bioinformatics — Posted on 2025-04-09
3588 In Silico Evaluation and Therapeutic Targeting of LVDD9B Protein for WSSV Inhibition: Molecular and Ecological Insights for Aquaculture Solutions
Iftehimul, M.; Hasan, N. A.; Akter, M. F.; Hossain, M. A.; Tima, S. A.; Kabir, A.; Choudhury, P.; Bhowmick, A.; Pranto, S. A.; Hasan, A. M. W.; Ansari, S. A.; Rahman, M. H.
10.1101/2025.04.05.647344 — bioinformatics — Posted on 2025-04-09
3589 A High-Precision Timing Method and Digital Interface for Closed-Loop TMS
Kahilakoski, O.-P.; Sinisalo, H.; Nieminen, J. O.; Alkio, K.; Valen, K.; Kozak, G.; Ilmoniemi, R. J.; Roine, T.
10.1101/2025.04.05.647340 — bioengineering — Posted on 2025-04-09
3590 NeuroSimo: an open-source software for closed-loop EEG- or EMG-guided TMS
Kahilakoski, O.-P.; Alkio, K.; Siljamo, O.; Valen, K.; Laurinoja, J.; Haxel, L.; Makkonen, M.; Mutanen, T. P.; Tommila, T.; Guidotti, R.; Pieramico, G.; Ilmoniemi, R. J.; Roine, T.
10.1101/2025.04.05.647342 — bioengineering — Posted on 2025-04-09
3591 Mucosal tissue NK cells tune their function between optimal anti-pathogen activity and tissue protection
Vick, S. C.; Domenjo-Vila, E.; Frutoso, M.; Glabman, R. A.; Warrier, L. S.; Hughes, S. M.; Kirby, A. C.; Fialkow, M. F.; Hladik, F.; Prlic, M.; Lund, J. M.
10.1101/2025.04.04.647286 — immunology — Posted on 2025-04-09
3592 Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection
Canaday, L. M.; Cox, A.; Feldman, H. A.; Seelamneni, H.; Ali, A.; Tuazon, J.; Calderon, L. B.; Bennett, S.; Yan, A.; Wilson, M.; Velu, V.; Waggoner, S. N.
10.1101/2025.04.05.647391 — immunology — Posted on 2025-04-09
3593 Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche
Guo, W.; Luan, J.; Huang, X.; Leon, D.; Good, J.; Nicholson, B.; Izumchenko, E.; Rosenberg, A. J.; Agrawal, N.; Bertacchi, B.; Bolotin, D.; Gunzer, M.; Ballesteros, I.; Hidalgo, A.; Miao, Y. P.
10.1101/2025.04.04.647324 — cancer biology — Posted on 2025-04-09
3599 Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery
Murad, J. P.; Christian, L.; Rosa, R.; Ren, Y.; Lee, E.; Lopez, L.; Park, A.; Yang, J.; Trac, C.; Adkins, L.; Chang, W.-C.; Martinez, C.; June, C. H.; Forman, S.; Ishihara, J.; Lee, J. K.; Stern, L.; Priceman, S. J.
10.1101/2025.04.04.647304 — bioengineering — Posted on 2025-04-09
3602 Development of circulating cell-free DNA reduced representation bisulfite sequencing for clinical methylomics diagnostics
De Koker, A.; Raman, L.; Van Paemel, R.; Van der Linden, M.; Van de Velde, S.; Van der Leest, P.; Van Gaever, B.; Zaka, A.; Vermaelen, K.; Demedts, I.; Surmont, V.; Himpe, U.; Dedeurwaerdere, F.; Ferdinande, L.; Claes, K.; De Wilde, J.; Timens, W.; De Jager, V.; Hiltermann, J.; De Wilde, B.; Menten, B.; De Preter, K.; Schuuring, E.; Van Dorpe, J.; Callewaert, N.
10.1101/663195 — genomics — Posted on 2025-04-09
3604 A subset of Haematopoietic Stem Cells resists Plasmodium infection-induced stress by uncoupling interferon sensing and metabolic activation
Georgiou, C.; Liu, Q.; Anton, S. G.; Bruno, F.; Birch, F.; Kinston, S.; Chabra, S.; Wilson, N.; Pospori, C.; Blagborough, A. M.; Gottgens, B.; Luis, T.; Lo Celso, C. L.
10.1101/2025.04.09.647965 — cell biology — Posted on 2025-04-09
3605 Comparative study of Anopheles gambiae larval habitats and larval densities in relation to physicochemical parameters in three urban sites in Abidjan district.
Kacou, K. Y. A.; Yokoly, N. F.; Le Bissonnais, S.; Zahouli, B. Z. J.; Jackson IK Kouame, J. K. I.; Tia, B. J.-P.; Koudou, G. B.
10.1101/2025.04.05.647363 — ecology — Posted on 2025-04-09
3606 A multi-institutional investigation of psilocybin's effects on mouse behavior
Lu, O. D.; White, K.; Raymond, K.; Liu, C.; Klein, A. S.; Green, N.; Vaillancourt, S.; Gallagher, A.; Shindy, L.; Li, A.; Li, R.; Zou, M.; Wallquist, K.; Casey, A. B.; Cameron, L. P.; Pomrenze, M. B.; Sohal, V.; Kheirbek, M. A.; Gomez, A. M.; Lammel, S.; Heifets, B. D.; Malenka, R. C.
10.1101/2025.04.08.647810 — neuroscience — Posted on 2025-04-09
3609 Adeno-associated viruses escort nanomaterials to specific cells and tissues
Nagao, K.; Vargas Paniagua, E.; Lei, K.; Beckham, J. L.; Worthington, P.; Manthey, M.; Ye, M.; Koehler, F.; Kim, Y. J.; Malkin, E.; Onoda, M.; Kent, N.; Michida, S.; Crespin Guerra, E.; Macfarlane, R. J.; Anikeeva, P.
10.1101/2025.04.04.647267 — bioengineering — Posted on 2025-04-09
3612 T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.
Bozkus, C. C.; Brown, M.; Velazquez, L.; Thomas, M.; Wilson, E. A.; O'Donnell, T.; Ruchnewitz, D.; Geertz, D.; Bykov, Y.; Kodysh, J.; Oguntuyo, K. Y.; Roudko, V.; Hoyos, D.; Srivastava, K.; Kleiner, G.; Alshammary, H.; Karekar, N.; McClain, C.; Gopal, R.; Nie, K.; Del Valle, D.; Delbeau-Zagelbaum, D.; Rodriguez, D.; Setal, J.; The Mount Sinai COVID-19 Biobank Team, ; Carroll, E.; Wiesendanger, M.; Gulko, P.; Charney, A.; Merad, M.; Kim-Schulze, S.; Lee, B.; Wajnberg, A.; Simon, V.; Greenbaum, B. D.; Chowell, D.; Vabret, N.; Luksza, M.; Bhardwaj, N.
10.1101/2024.10.23.619918 — immunology — Posted on 2025-04-09
3615 Drosophila Modeling Identifies Increased Sleep as a Link Between Insomnia and Cardiovascular Disease
Mandigo, T. R.; Abou Daya, F.; Patel, D.; Math, S. R.; Ober, L.; Maher, M.; Melkani, G. C.; Walker, J. A.; Saxena, R.
10.1101/2025.04.07.647668 — neuroscience — Posted on 2025-04-09
3616 Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies
Sridhar, S.; Vystrcilova, M.; Khani, M. H.; Karamanlis, D.; Schreyer, H. M.; Ramakrishna, V.; Krueppel, S.; Zapp, S. J.; Mietsch, M.; Ecker, A.; Gollisch, T.
10.1101/2024.03.05.583449 — neuroscience — Posted on 2025-04-09
3618 Evolutionary expression patterns in developing biofilms of uropathogenic Escherichia coli reveal embryo-like features
Tusar, A.; Koska, S.; Futo, M.; Kasalo, N.; Svetlicic, E.; Corak, N.; Domazet-Loso, M.; Franjevic, D.; Mijakovic, I.; Domazet-Loso, T.
10.1101/2025.04.04.647276 — evolutionary biology — Posted on 2025-04-09
3620 Implementing N-terminomics and machine learning to probe in vivo Nt-arginylation
Ju, S.; Nawale, L.; Lee, S.; Kim, J. G.; Lee, H.; Park, N.; Kim, D. H.; Cha-Molstad, H.; Lee, C.
10.1101/2025.04.09.646507 — systems biology — Posted on 2025-04-09
3621 On-demand insulin manufacturing using cell-free systems with an "on-column" conversion approach
Borhani, S. G.; Levine, M. Z.; Gurramkonda, C.; Qu, Y.; Tao, D.; LeClair, C. A.; Swartz, J.; Rao, G.
10.1101/2025.04.08.633785 — synthetic biology — Posted on 2025-04-09
3623 AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification
Hold, L. A.; Migotsky, N.; Chen, J.; Steltzer, S. S.; Cordts, P.; Bae, S.-H.; Grossman, S.; Lamia, S.; Phillips, T.; O'Meara, M. J.; Davis, C. S.; Brooks, S. V.; Akbar, M.; Millar, N. L.; Killian, M. L.; Abraham, A. C.
10.1101/2025.01.31.635920 — pathology — Posted on 2025-04-09
3625 IFI16 senses and protects stalled replication forks
Gamble, A.; Ward, T. A.; Wheeler, O. P.; Jones, C. M.; Bennett, L.; Vernon, E. G.; Thandendran, V.; Morris, J. P.; Ceppi, I.; Halder, S.; Borello, D.; Walker, T. D.; Rajan, J.; Dunphy, G.; Cejka, P.; Unterholzner, L.; Staples, C. J.
10.1101/2025.04.07.646548 — cancer biology — Posted on 2025-04-09
3628 A global P-Process map to avoid P-value abuse
Xu, J.; Wei, S.; Tao, J.; Sun, C.; Chen, H.; Duan, L.; Shang, Z.; Lyu, W.; Lyu, H.; Zhang, M.; Jiang, Y.
10.1101/2025.04.06.646254 — bioinformatics — Posted on 2025-04-09
3632 Engineering IspH for Enhanced Terpenoid Yield: Computational and Molecular Dynamics Studies
Runthala, A.; Machrela, S.; Varadharajan, V.; Selvan, S. T.; Sharma, M.; Kaur, N.; Phulara, S. C.; Ahmad, S. N.; Ghneim, H. K.
10.1101/2025.04.07.643449 — bioengineering — Posted on 2025-04-09
3634 Gap-free genomes and transcriptomes uncover race-specific effectors in watermelon wilt pathogen Fusarium oxysporum f. sp. niveum
Ayhan, D. H.; Wang, H.; Zhang, L.; Wang, G.; Yi, S.; Meng, D.; Xue, L.; Geng, X.; Kong, Z.; Wang, X.; Wang, L.; Yang, Q.; Wang, X.; Deng, Y.; Zhang, X.; Guo, L.
10.1101/2025.04.04.647254 — genomics — Posted on 2025-04-09
3640 Multiscale characterization of Caenorhabditis elegans mutants to probe functional mechanisms of human actin pathological variants
Hecquet, T.; Arbogast, N.; Suhner, D.; Goetz, A.; Amann, G.; Yürekli, S.; Marangoni, F.; Greve, J. N.; Di Donato, N.; Reymann, A.-C.
10.1101/2024.07.22.604239 — cell biology — Posted on 2025-04-09
3641 Dynamic phosphorylation of Hcm1 promotes fitness in chronic stress
Conti, M. M.; Bail, J. P.; Reynolds, A. R.; Budge, L. G.; Flynn, M. J.; Li, R.; Zhu, L. J.; Benanti, J. A.
10.1101/2024.09.18.613713 — cell biology — Posted on 2025-04-09
3643 Observation of persister cell histories reveals diverse modes of survival in antibiotic persistence
Umetani, M.; Fujisawa, M.; Okura, R.; Nozoe, T.; Suenaga, S.; Nakaoka, H.; Kussell, E.; Wakamoto, Y.
10.1101/2021.10.28.466227 — microbiology — Posted on 2025-04-09
3646 Unraveling anti-inflammatory metabolic signatures of Glycyrrhiza uralensis and isoliquiritigenin through multiomics
Kiuchi, S.; Chung, M. H.; Nakaya, T.; Ohbuchi, K.; Tsumagari, K.; Imami, K.; Otoguro, Y.; Nitta, T.; Yamamoto, H.; Sasaki, K.; Tsugawa, H.
10.1101/2025.04.08.647718 — systems biology — Posted on 2025-04-09
3650 Mitochondrial Responses to Conventional and Ultra-high Dose Rate (FLASH) Radiation
Caggiano, E.; Lopez-Hernandez, A.; Waldrop, T.; Liu, K.; Gatica-Gutierrez, H.; Vargas-Hernandez, S.; Mims, N.; Acevedo-Diaz, A.; Velasquez, B.; Neil, D.; Aguilar, E.; Meyer, M.; Echeverria, G. V.; Koong, A.; Spiotto, M.; Gustavsson, A.-K.; Schueler, E. V.
10.1101/2025.04.03.647049 — cancer biology — Posted on 2025-04-09
3651 Resolving somatic SVs via full-length sequence model-based local graph-genome optimization
Tu, K.; Zhang, Q.; Li, Y.; Li, Y.; Yuan, L.; Wang, J.; Tang, J.; Xia, L.; Huang, W.; Xie, D.
10.1101/2025.02.11.636543 — bioinformatics — Posted on 2025-04-09
3652 Generalized Biological Foundation Model with Unified Nucleic Acid and Protein Language
He, Y.; Fang, P.; Shan, Y.; Pan, Y.; Wei, Y.; Chen, Y.; Chen, Y.; Liu, Y.; Zeng, Z.; Zhou, Z.; Zhu, F.; Holmes, E. C.; Ye, J.; Li, J.; Shu, Y.; Shi, M.; Li, Z.
10.1101/2024.05.10.592927 — bioinformatics — Posted on 2025-04-09
3653 Bridging data gaps: predicting inadequate micronutrient intake with machine learning
Voukelatou, V.; Tang, K.; Lauzana, I.; Jangid, M.; Martini, G.; de Pee, S.; Knight, F.; Piovani, D.
10.1101/2025.04.08.647715 — bioinformatics — Posted on 2025-04-09
3654 NetSyn: genomic context exploration of protein families
Stam, M.; Langlois, j.; Chevalier, C.; Mainguy, J.; Reboul, G.; Bastard, K.; Medigue, C.; Vallenet, D.
10.1101/2023.02.15.528638 — bioinformatics — Posted on 2025-04-09
3657 Lysine deacetylation inhibition reverses TDP-43 mislocalization and in combination with arimoclomol ameliorates neuromuscular pathology
Scozzari, S.; Columbro, S. F.; Favagrossa, M.; Tortarolo, M.; Cagnotto, A.; Salmona, M.; De Marco, G.; Bendotti, C.; Calvo, A.; Pasetto, L.; Bonetto, V.
10.1101/2024.12.15.628528 — neuroscience — Posted on 2025-04-09
3658 SLC44A1 deficiency impedes myelin development in the central nervous system
Chen, Q.; Chen, X.; Li, Z.-H.; Shao, Q.; Huang, H.; Zhou, W.; Qiu, M.; Su, Z.; Liu, P.; He, C.
10.1101/2025.04.08.647819 — neuroscience — Posted on 2025-04-09
3659 A vectorial code for semantics in human hippocampus
Franch, M.; Mickiewicz, E. A.; Belanger, J.; Chericoni, A.; Chavez, A. G.; Katlowitz, K.; Mathura, R.; Paulo, D.; Bartoli, E.; Kemmer, S.; Piantadosi, S. T.; Provenza, N.; Watrous, A.; Sheth, S.; Hayden, B.
10.1101/2025.02.21.639601 — neuroscience — Posted on 2025-04-09
3664 Gaps and Advances in Long-Term Monitoring of Antarctic Near-Shore and Terrestrial Ecosystems
Borgmeier, A.; Bergstrom, D.; Cary, S. C.; Convey, P.; Cummings, V.; Deregibus, D.; Hong, S. G.; Lee, C. K.; Lee, H.; Libertelli, M.; Robinson, S.; Schiaparelli, S.; Sultan, E.; Tsujimoto, M.; Verleyen, E.; Adams, B. J.
10.1101/2025.04.03.647064 — ecology — Posted on 2025-04-09
3666 Biobanking of Biological Samples at Room Temperature
Vangala, R. K.; Kanukollu, S.; M S, P.; Nair, J.; Vangala, A. B.; Shankar, A.; Upadhyay, B.; Palpandi, S.; Nagendran, J.; Nair, P. N.; Murugaian, E. E.
10.1101/2025.04.08.646969 — molecular biology — Posted on 2025-04-09
3669 AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung Injury
Soetopo, D.; Mayr, C. H.; Fundel-Clemens, K.; Ramirez, F.; Viollet, C.; Dick, A.; Rust, W.; Santacruz, D.; Hoevels, Y.; Applebee, C. J.; Legg, S.; Funk, A.; Schnapp, G.; Padget, J.; Strobel, B.; Thomas, M. J.; Ward, S. G.; Larijani, B.; Geillinger-Kaestle, K.
10.1101/2025.04.07.647567 — molecular biology — Posted on 2025-04-09
3671 Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD
Xie, L.; Zhu, Y.; Hurtle, B. T.; Wright, M.; Robinson, J. L.; Mauna, J. C.; Brown, E. E.; Ngo, M.; Bergmann, C. A.; Xu, J.; Merjane, J.; Gleixner, A. M.; Grigorean, G.; Liu, F.; Rossoll, W.; Lee, E. B.; Kiskinis, E.; Chikina, M.; Donnelly, C. J.
10.1101/2025.04.07.646890 — molecular biology — Posted on 2025-04-09
3675 Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNAArg
Dutt, S.; Lai, L. B.; Mehta, R.; Karawdeniya, B. I.; Bandara, Y. M. N. D. Y.; Clulow, A. J.; Glatt, S.; Gopalan, V.; Kluth, P.
10.1101/2025.04.08.647894 — biophysics — Posted on 2025-04-09
3678 A novel regulator of the fungal phosphate starvation response revealed by transcriptional profiling and DNA affinity purification sequencing
Huberman, L. B.; Wu, V. W.; Kowbel, D. J.; Lee, J.; Daum, C.; Singan, V. R.; Grigoriev, I. V.; O'Malley, R. C.; Glass, L.
10.1101/2025.04.07.647663 — genetics — Posted on 2025-04-09
3679 D-Lactate drives cytotoxicity in Th1 cells by limiting mitochondrial ROS production through enhanced glyoxalase system activity
Madrigal-Aviles, A.; Plajer, V.; Serve, S.; Dzamukova, M.; Soriano-Baget, L.; Brenner, D.; Mashreghi, M.-F.; Loehning, M.
10.1101/2025.04.03.647060 — immunology — Posted on 2025-04-09
3680 Generation of two Betacellulin CRISPR-Cas9 knockout hiPSC lines to study affected EGF system paradigm in Schizophrenia
Cota-Coronado, A.; Manning, M.; Kim, D.-H.; Lee, J.; Gibbons, A.; Rosenbluh, J.; Hill, R.; Sundram, S.
10.1101/2025.04.07.647671 — neuroscience — Posted on 2025-04-09
3681 Antibiotic Use and Resistance in Zambia's Aquaculture Sector: Assessing Knowledge, Attitudes, and Practices Among Fish Farmers
Ndashe, K.; Mainda, G.; Makungu, C.; Caudell, M.; Changula, K.; Mtui-Malamsha, N.; Kimani, T.; Muma, J.; Nyirenda, M.; Sinkala, M.; Hang'ombe, B.
10.1101/2025.04.07.647520 — scientific communication and education — Posted on 2025-04-09
3691 Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model
Lin, Y.-H.; Dharmaraj, T.; Chen, Q.; Echterhof, A.; Manasherob, R.; Zhang, L. J.; Li, Z.; de Leeuw, C.; Peterson, N. A.; Chang, T. H. W.; Stannard, W.; Hajfathalian, M.; Hargil, A.; Martinez, H. A.; Pourtois, J.; Blankenberg, F. G.; Amanatullah, D.; Chaudhuri, O.; Bollyky, P. L.
10.1101/2024.05.07.593005 — bioengineering — Posted on 2025-04-09
3693 Toxoplasma gondii RAD51 recombinase is required to overcome DNA replication stress and its inactivation leads to bradyzoite differentiation
Cartagena, A. M. S.; Arias, A. A.; Cristaldi, C.; Ganuza, A.; Gonzalez, M. M.; Corvi, M. M.; Sullivan, W. J.; Vanagas, L.; Angel, S. O.
10.1101/2025.04.08.647840 — molecular biology — Posted on 2025-04-08
3696 Cell division protein A (CdpA) organises and anchors the division ring at midcell in haloarchaea
Liao, Y.; Shinde, V. D.; Hu, D.; Xu, Z.; Soderstrom, B.; Michie, K. A.; Duggin, I. G.
10.1101/2024.07.17.603854 — microbiology — Posted on 2025-04-09
3698 m6A regulates ADAR1-mediated RNA editing during macrophage activation
Griesche, V.; Di Giorgio, S.; Tellioglu, I.; Kao, C.-Y.; Lorenzo, J. P.; Pezzella, L.; Brettschneider, J.; Stoecklin, G.; Papavasiliou, F. N.
10.1101/2025.01.28.635339 — immunology — Posted on 2025-04-09
3702 A lipidomic exploration of the effects of high-intensity interval exercise in healthy men after metformin intake
Neuhaus, R.; Meikopoulos, T.; Gradillas, A.; Gonzalez-Riano, C.; Theodoridis, G.; Nikolaidis, S.; Mougios, V.; Barbas, C.; Gika, H.; VILLASENOR, A.
10.1101/2025.04.02.646809 — systems biology — Posted on 2025-04-09
3703 Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma
Kraft, A.; Toenz, A.; Schlaepfer, F.; Ronner, M.; Orlowski, V.; Kirschner, M. B.; Bein, J.; Wild, P. J.; Boeva, V.; Opitz, I.; Meerang, M.
10.1101/2025.04.04.647264 — cancer biology — Posted on 2025-04-09
3704 Exploiting macropinocytosis for therapeutic intervention in RAS mutant Multiple Myeloma
Beals, N.; Ramirez, C.; Koide, A.; Hauser, A. D.; Davies, F.; Koide, S.; Morgan, G.; Bar-Sagi, D.
10.1101/2025.04.04.647098 — cancer biology — Posted on 2025-04-09
3705 Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblasts
Dominguez-Garcia, S.; Rodriguez, J.; Julia, M.; Coursier, D.; Perez-Lopez, C.; Carnicero, P.; Villar, A. V.; von Kriegsheim, A.; Calvo, F.
10.1101/2025.04.04.647210 — cancer biology — Posted on 2025-04-09
3708 The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli
Amarasinghe, C. I.; Chang, M.-H.; Männik, J.; Retterer, S. T.; Lavrentovich, M. O.; Männik, J.
10.1101/2025.04.05.647368 — biophysics — Posted on 2025-04-09
3709 Polymorphic tandem repeats influence cell type-specific gene expression across the human immune landscape
Tanudisastro, H. A.; Cuomo, A. S. E.; Weisburd, B.; Welland, M.; Spenceley, E.; Franklin, M.; Xue, A.; Bowen, B.; Wing, K.; Tang, O.; Gray, M.; Reis, A. L. M.; Margoliash, J.; Kurtas, E. N.; Pullin, J.; Lee, A. S.; Brand, H.; Harper, M.; Bobowik, K.; Silk, M.; Marshall, J.; Bakiris, V.; Swapna Madala, B.; Uren, C.; Bartie, C.; Senabouth, A.; Dashnow, H.; Fearnley, L.; Martin Trujillo, A.; Dolzhenko, E.; Qiao, Z.; Grieve, S.; Nguyen, T.; Ben-David, E.; Chen, L.; Farh, K.; Talkowski, M.; Alexander, S. I.; Siggs, O. M.; Gruenschloss, L.; Nicholas, H. R.; Piscionere, J.; Simons, C.; Wallace, C.; G
10.1101/2024.11.02.621562 — genomics — Posted on 2025-04-09
3710 Phenotypic plasticity meets and moulds carry-over effects in sea rock-pool mosquitoes
Cordeschi, G.; Bisconti, R.; Mastrantonio, V.; Canestrelli, D.; Porretta, D.
10.1101/2024.07.24.604954 — ecology — Posted on 2025-04-09
3711 Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture
Tittelmeier, J.; Sandhof, C. A.; Martin, N.; El-Kabarity, D.; Ngonza-Nito, S.-B.; Melki, R.; Nussbaum-Krammer, C.
10.1101/2024.10.24.619578 — cell biology — Posted on 2025-04-09
3712 CetZ1-dependent polar assembly of the archaeal motility machinery
Brown, H. J.; Islam, M. I.; Ruan, J.; Baker, M. A.; Ithurbide, S.; Duggin, I. G.
10.1101/2024.05.02.592137 — microbiology — Posted on 2025-04-09
3713 Functional Role for Cas Cytoplasmic Adaptor Proteins During Cortical Axon Pathfinding
Estep, J. A.; Treptow, A. M.; DePalma, P. A.; Williamson, P.; Wong, W.; Riccomagno, M. M.
10.1101/2025.04.08.647868 — neuroscience — Posted on 2025-04-09
3714 Genetic diversity shapes behavioral outcomes and reveals sex differences in mice exposed to early life stress
Nguyen, J.; Shimizu, K.; Zlotnik, V.; Nguyen, M. N.; Del Toro, S.; Nguyen, M. T.; Ronquillo, J.; Halladay, L. R.
10.1101/2025.04.08.647890 — neuroscience — Posted on 2025-04-09
3715 Insights into early cochlear damage induced by potassium channel deficiency
Rias, E.; Carignano, C.; Castagna, V. C.; Dionisio, L.; Ballestero, J. A.; Paolillo, G.; Ouwerkerk, I.; Gomez-Casati, M. E.; Spitzmaul, G.
10.1101/2025.04.08.647809 — neuroscience — Posted on 2025-04-09
3717 The precision of hippocampal representations predicts incremental value-learning across the adult lifespan
vanGeen, C.; Lempert, K. M.; Cohen, M.; MacNear, K. A.; Reckers, F. M.; Zaneski, L.; Kable, J. W.; Wolk, D.
10.1101/2025.04.08.647815 — neuroscience — Posted on 2025-04-09
3722 HuR-Driven Reversible Mitochondrial Shuttling Buffers Cytosolic miRNA Levels in Hepatic Cells
Banerjee, S.; Hom Choudhury, S.; Chatterjee, S.; Hu, G.; Mukherjee, K.; Bhattacharyya, S. N.
10.1101/2025.04.08.647748 — cell biology — Posted on 2025-04-08
3724 Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making
Wu, H.; Shen, L.; Indajang, J.; Savalia, N. K.; Johnson, T. G.; Qu, J.; Bender, K. J.; Kwan, A. C.
10.1101/2025.04.08.647866 — neuroscience — Posted on 2025-04-09
3727 NAD+ Sensing by PARP7 Regulates the C/EBPβ-Dependent Transcription Program in Adipose Tissue In Vivo
Stokes, M. S.; Kim, Y. J.; Kim, Y.; Koul, S.; Chiu, S.-P.; Dasovich, M.; Zuniga, J.; Nandu, T.; Huang, D.; Mathews, T. P.; Solmonson, A.; Camacho, C. V.; Kraus, W. L.
10.1101/2025.04.07.647692 — cell biology — Posted on 2025-04-08
3728 Actin cytoskeletal remodeling requires the interaction between Solo and LARG in response to substrate stiffness
Kunitomi, A.; Toyofuku, Y.; Chiba, S.; Higashitani, N.; Higashitani, A.; Sato, S.; Mizuno, K.; Ohashi, K.
10.1101/2025.04.08.647765 — cell biology — Posted on 2025-04-08
3729 Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers
Runnebohm, A. M.; Wijeratne, H. S.; Peck Justice, S. A.; Wijeratne, A. B.; Roy, G.; Smith, J. J.; Singh, N.; Hergenrother, P.; Boothman, D. A.; Motea, E. A.; Mosley, A. L.
10.1101/2024.05.15.594427 — cancer biology — Posted on 2025-04-08
3730 Identifying the proximate mechanisms that generate variation in nutritional plasticity for fecundity in Drosophila melanogaster
Nogueira Alves, A.; Chakraborty, A.; Wansbrough, M.; Walter, G. M.; Piper, M. D. W.; Sgro, C. M.; Mirth, C. K.
10.1101/2023.03.07.531575 — evolutionary biology — Posted on 2025-04-08
3732 Adenovirus maturation establishes the transcription competent packaging of its genome
Baumgartl, C.; Holzinger, S.; Schwartz, U.; Franken, L. E.; Gruenewald, K.; Wodrich, H.; Laengst, G.
10.1101/2025.04.08.647783 — molecular biology — Posted on 2025-04-08
3739 Plant pathogenic Ralstonia share two core methyl-accepting chemoreceptors that drive chemotaxis toward distinct amino acid profiles
Avalos, J. K.; Elmgreen, V.; Guerrero, C. R.; Grulla, K. J.; Miqueo, K.; Parales, R. E.; Lowe-Power, T. M.; Schomer, R. A.
10.1101/2025.04.07.647700 — microbiology — Posted on 2025-04-08
3740 Molecular interplay between ComEC domains leads to efficient DNA translocation during natural transformation
Stedman, M. J. M.; Deselaers, S.; Braus, S. A. G.; Wang, D.; Gregori Balaguer, M.; Gossert, A. D.; Hospenthal, M. K.
10.1101/2025.04.08.647572 — microbiology — Posted on 2025-04-08
3744 Visual pathway origins: an electron microscopic volume for connectomic analysis of the human foveal retina
Kim, Y. J.; Packer, O.; Macrina, T.; Pollreisz, A.; Curcio, C. A.; Lee, K.; Kemnitz, N.; Ih, D.; Nguyen, T.; Lu, R.; Popovych, S.; Halageri, A.; Bae, J. A.; Strout, J.; Gerhard, S.; Smith, R. G.; Martin, P. R.; Grünert, U.; Dacey, D.
10.1101/2025.04.05.647403 — neuroscience — Posted on 2025-04-08
3745 Novel Aromatic Polyhydroxyalkanoates from Engineered Cupriavidus necator H16: Expanding Bio-Polyester Synthesis from Renewable Feedstocks
Averesch, N. J. H.; Pane, V. E.; Kracke, F.; Chatterjee, S.; Berliner, A. J.; Ziesack, M.; Nangle, S. N.; Waymouth, R. M.; Criddle, C. S.
10.1101/2021.12.12.472320 — synthetic biology — Posted on 2025-04-08
3746 Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells
Zawieja, S. D.; Pea, G. A.; Broyhill, S. E.; Patro, A.; Bromert, K. H.; Norton, C. E.; Kim, H. J.; Sivasankaran, S. K.; Li, M.; Castorena-Gonzalez, J. A.; Drumm, B. T.; Davis, M. J.
10.1101/2023.08.24.554619 — physiology — Posted on 2025-04-08
3747 Menin-MLL1 complex cooperates with NF-Y to promote HCC survival
Dzama-Karels, M.; Kuhlers, P.; Sokolowski, M.; Brinkman, J. A.; Morris, J. P.; Raab, J. R.
10.1101/2025.04.05.647381 — cancer biology — Posted on 2025-04-08
3748 Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing
Nesic, K.; Geissler, F.; Xu, L.; Kyran, E.; Beard, S.; Vandenberg, C. J.; Liddell, B.; Olechnowicz, S. W. Z.; Topp, M.; McNally, O.; Ratnayake, G.; Traficante, N.; Australian Ovarian Cancer Study, ; DeFazio, A.; Bowtell, D. D. L.; Pappenfuss, T.; Zhang, F.; Dobrovic, A.; Waddell, N.; Scott, C. L.; Kondrashova, O.; Wakefield, M. J.
10.1101/2025.04.07.647418 — cancer biology — Posted on 2025-04-08
3749 Learning the dynamic organization of a replicating bacterial chromosome from time-course Hi-C data
Harju, J.; Messelink, J. J. B.; Troeger, L.; Gradziuk, G.; Rathnayaka, I.; Thanbichler, M.; van Teeseling, M. C. F.; Broedersz, C. P.
10.1101/2025.04.03.647011 — biophysics — Posted on 2025-04-08
3753 Activation of SPARDA defense system by filament assembly reveals beta-relay signaling mechanism widespread in prokaryotic Argonautes
Jurgelaitis, E.; Zagorskaite, E.; Kopustas, A.; Asmontas, S.; Manakova, E.; Dalgediene, I.; Tylenyte, U.; Silanskas, A.; Toliusis, P.; Grybauskas, A.; Tutkus, M.; Venclovas, C.; Zaremba, M.
10.1101/2025.04.08.647717 — biochemistry — Posted on 2025-04-08
3754 Isotope tracing-based metabolite identificationfor mass spectrometry metabolomics
Secilmis, D.; Begzati, A.; Grankvist, N.; Roci, I.; Watrous, J.; Majithia, A. R.; Smith, G. I.; Klein, S.; Jain, M.; Nilsson, R.
10.1101/2025.04.07.647691 — biochemistry — Posted on 2025-04-08
3755 Structural basis for the ubiquitin chain recognition of the human 26S proteasome
Amann, S. J.; Kalis, R.; Fottner, M.; Knaudt, H.; Grishkovskaya, I.; Kotisch, H.; Zuber, J.; Lang, K.; Brown, N. G.; Haselbach, D.
10.1101/2025.04.07.647569 — biochemistry — Posted on 2025-04-08
3757 General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants
Tedman, A.; Olson, J. A.; Kim, M.; Foye, C. C.; Jackson, J.; McDonald, E. F.; McKee, A. G.; Noguera, K.; Kuntz, C. P.; Meiler, J.; Oliver, K. E.; Plate, L.; Schlebach, J. P.
10.1101/2025.04.03.647093 — biochemistry — Posted on 2025-04-08
3761 TUCL-Seq for miRNA single molecule sequencing
Fan, J.; Li, Z.; You, X.; Liu, L.; Jin, H.; Wu, P.; Han, Y.; Sun, L.; Xu, P.; Liu, Y.; Luo, J.; Yan, Q.
10.1101/2025.04.07.646966 — biochemistry — Posted on 2025-04-08
3762 Molecular mechanism for cargo-mediated initiation of kinesin-1 activation
Shukla, S.; Cross, J. A.; Kish, M.; Yadav, S. K.; Weijman, J. F.; O'Regan, L.; Mantell, J.; Borucu, U.; Leng, X.; Schaffitzel, C.; Phillips, J. J.; Woolfson, D. N.; Dodding, M. P.
10.1101/2025.04.08.647705 — biochemistry — Posted on 2025-04-08
3766 Genetic and functional analysis of unproductive splicing using LeafCutter2
Najar, C. F. B. A.; Feng, R.; Dai, C.; Fair, B.; Hauck, Q.; Li, J.; Cao, X.; Dey, K. K.; De Jager, P.; Bennett, D.; The Alzheimer's Disease Sequencing Project Functional Genomics Consortium, ; Liu, X.; Wang, G.; Li, Y.
10.1101/2025.04.06.646893 — genomics — Posted on 2025-04-08
3768 Stochastic Phylogenetic Models of Shape
Stroustrup, S.; Pedersen, M. A.; van der Meulen, F.; Sommer, S.; Nielsen, R.
10.1101/2025.04.03.646616 — evolutionary biology — Posted on 2025-04-08
3770 Flexible Methods for Species Distribution Modeling with Small Samples
Maitner, B. S.; Richards, R. L.; Carlson, B.; Drake, J. M.; Merow, C.
10.1101/2025.04.03.647025 — ecology — Posted on 2025-04-08
3771 Interactions Between Native Soil Microbiome and a Synthetic Microbial Community Reveals Bacteria with Persistent Traits
Velte, J. M.; Mudiyanselage, S. D.; Hofmann, O. F.; Lee, S. T. M.; Huguet-Tapia, J. C.; Miranda, M.; Martins, S. J.
10.1101/2025.04.08.647796 — microbiology — Posted on 2025-04-08
3773 Cationic antimicrobial copolymers reveal immunomodulatory properties in LPS stimulated macrophages in vitro
Laroque, S.; Harris, J.; Rajendrakumar, S.; Vasilyev, V.; Grewal, J.; Dallmann, R.; Locock, K.; Perrier, S.
10.1101/2025.04.08.647761 — microbiology — Posted on 2025-04-08
3774 Native epitranscriptome sequencing reveals Hepatitis B virus RNA stability protected by heavy m6A modification
Su, P.-Y.; Lin, Y.-H.; Foustine, S.; Chang, C.-H.; Gupta, A.; Papas, B. N.; van der Toorn, W.; von Kleist, M.; Smyth, R.; Morgan, M.; Chen, P.-J.; Tsai, K.
10.1101/2025.04.08.647702 — microbiology — Posted on 2025-04-08
3776 Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort
Faye, R.; Mbow, A. A.; Tall, B.; Gaye, A.; Ndoye, A. M.; Gueye, R.; Diallo, D.; Faye, F. N.; Talla, C.; Dia, N.; Mbengue, B.; Pelleau, S.; Niang, M.; Seydi, M.; Sall, A. A.; Taïeb, F.; Loucoubar, C.; White, M.; Poiret, T.; Vigan-Womas, I.
10.1101/2025.04.07.647508 — immunology — Posted on 2025-04-08
3777 High fat diet but not glucocorticoid-induced obesity results in fatty liver
Agas, A.; Sharma, S.; Narciso, A.; Wilson, J.; Kilkenny, E.; Lantier, L.; Uddin, A.; Patel, R.; McGraw, T.; Teruel, M. N.
10.1101/2025.04.03.647107 — physiology — Posted on 2025-04-08
3778 Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma
Suresh, V.; Hafemeister, C.; Konstantinou, A.; Grissenberger, S.; Sturtzel, C.; Cidre-Aranaz, F.; Wenninger-Weinzierl, A.; Zylka, M.; Queiros, K.; Kurek, D.; Sastre, A.; Alonso, J.; Distel, M.; Obenauf, A.; Gruenewald, T. G. P.; Halbritter, F.; Kovar, H.; Fock, V.
10.1101/2025.04.03.647002 — cancer biology — Posted on 2025-04-08
3779 CIT tumor lines: A novel series of immunogenic squamous cell skin carcinoma cell lines derived from chemical carcinogenesis
Tanaka, M.; Letchworth, R.; Barnes, A. A.; Lum, L.; Hughes, S.; Schlauderaff, G.; Chaudhary, P.; Ng, K. M.; Superville, D.; Martinez Luna, C.; Gonzalez, M.; Grossman, A.; Reeves, M.
10.1101/2025.04.03.647071 — cancer biology — Posted on 2025-04-08
3782 REvolutionH-tl: A Fast and Robust Tool for Decoding Evolutionary Gene Histories
Ramirez-Rafael, J. A.; Korchmaros, A.; Avina-Padilla, K.; Lopez-Sanchez, A.; Martinez-Medina, G.; Hernandez-Alvarez, A. J.; Hellmuth, M.; Stadler, P. F.; Hernandez-Rosales, M.
10.1101/2025.04.03.646975 — bioinformatics — Posted on 2025-04-08
3785 Robust Consensus Nuclear and Cell Segmentation
Irfan, M. O.; Gonzalez-Solares, E. A.; Whitmarsh, T.; Molaeinezhad, A.; Al Sa'd, M.; Mulvey, C. M.; Paez Ribes, M.; Bressan, D.; Walton, N. A.
10.1101/2025.04.03.646876 — bioinformatics — Posted on 2025-04-08
3788 Perturbing RNA localization for functional study in neurons
Qi, S.; Han, M.; Fu, M. L.; Zhu, Y.; Choi, A. A.; Li, E.; Bezney, J.; Cai, S.; Miles, L.; Ma, Y.
10.1101/2025.04.05.646707 — bioengineering — Posted on 2025-04-08
3789 Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5
Mahen, K. K.; Massey, W. J.; Orabi, D.; Brown, A. L.; Jaramillo, T. C.; Burrows, A.; Horak, A. J.; Dutta, S.; Mrdjen, M.; Mouannes, N.; Varadharajan, V.; Osborne, L. J.; Ye, X.; Yarbrough, D. M.; Grubb, T.; Zajczenko, N.; Hohe, R.; Banerjee, R.; Linga, P.; Laungani, D.; Hajjar, A.; Sangwan, N.; Dwidar, M.; Buffa, J. A.; Swanson, G. R.; Wang, Z.; Brown, J. M.
10.1101/2025.04.03.647082 — biochemistry — Posted on 2025-04-08
3794 Cell type-specific enhancers regulate IL-22 expression in innate and adaptive lymphoid cells
Saini, A.; Hopkins, L. S.; Serna, V. A.; McCullen, M. V. D.; Selner, N. G.; Bhattarai, B.; Fachi, J. L.; Glynn, R.; Hayer, K. E.; Bassing, C. H.; Colonna, M.; Oltz, E. M.
10.1101/2025.04.02.646834 — immunology — Posted on 2025-04-08
3796 Partial cross-resistance of oats to different Fusarium species and the role of trichomes in susceptibility
Schurack, S.; Rodemann, C.; Oldach, K.; Beuch, S.; Brodfuehrer, S.; von Tiedemann, A.; Herrmann, M. H.
10.1101/2025.04.08.647721 — plant biology — Posted on 2025-04-08
3797 The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation
Myakala, K.; Wang, X. X.; Shults, N. V.; Hughes, E.; Ribeiro, P. d. C.; Penjweini, R.; Link, K.; Barton, K.; Jones, B. A.; Krawczyk, E.; Clarkson-Paredes, C.; Popratiloff, A.; Knutson, J. R.; cowart, l. a.; Levi, M.
10.1101/2025.04.02.646892 — pharmacology and toxicology — Posted on 2025-04-08
3798 Injury-induced electrochemical coupling triggers regenerative cell proliferation
Liu, J.; Nerli, E.; Duclut, C.; Vishen, A. S.; Berbee, N.; Kaufmann, S.; Ponce, C.; Arrenberg, A. B.; Julicher, F.; Mateus, R.
10.1101/2025.04.03.647033 — biophysics — Posted on 2025-04-08
3799 Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver
Tong, C. Y.; Li, C.; Hurni, C.; Jacq, A.; Nie, X. Y.; Guy, C. R.; Suh, J. H.; Wong, R. K. W.; Merlin, C.; Naef, F.; Menet, J. S.; Jiang, Y.
10.1101/2025.04.03.647044 — bioinformatics — Posted on 2025-04-08
3800 Metric Validation for Detection of Delayed and Directed Coupling
Dembny, K.; Farooqi, H.; Herman, A. B.; Netoff, T. I.; Darrow, D. P.
10.1101/2025.04.02.646886 — bioinformatics — Posted on 2025-04-08
3801 Physicochemical and microbiome changes in queso crema de Chiapas during ripening
Ocampo Morales, B. N.; Hernandez Montes, A.; Estrada, K.; Valadez Moctezuma, E.
10.1101/2025.04.02.646936 — bioinformatics — Posted on 2025-04-08
3803 Method for Extracellular Electrochemical Impedance Spectroscopy on Epithelia
Chien, A. J.; Lewallen, C. F.; Khor, H.; Vazquez Cegla, A.; Guo, R.; McCarty, N. A.; Bharti, K.; Forest, C. R.
10.1101/2025.04.02.646694 — bioengineering — Posted on 2025-04-08
3804 Extracellular loops of the β-barrel domain catalyze rapid folding for function of self-associating autotransporters
Yuan, X.; Johnson, M. D.; Long, J.; Zhang, J.; Lo, A. W.; Paxman, J. J.; Phan, D.; Heras, B.; Schembri, M. A.; Huysmans, G. H. M.; Henderson, I. R.; Doyle, M. T.; Leyton, D. L.
10.1101/2025.04.08.647479 — biochemistry — Posted on 2025-04-08
3805 The genome sequence of the hemlock woolly adelgid, Adelges tsugae Annand 1924
Brunet, B. M. T.; Dial, D. T.; Burke, G. R.; von Dohlen, C. D.; Freitas, J. D.; Sanderson, H.; Chida, A. R.; Jones, S. J.; Martin, F. J.; Haggerty, L.; Scherer, S. W.; Ragoussis, I.; Jones, S. J. M.; Foottit, R. G.; Havill, N. P.
10.1101/2025.04.07.644581 — genomics — Posted on 2025-04-08
3806 Genome-wide association study reveals candidate loci for resistance to anthracnose in blueberry
Ghimire, L.; Adunola, P.; Harmon, P. F.; Azevedo, C. F.; Schultz, T. J.; Leme, B.; Enciso-Rodriguez, F. E.; Benevenuto, J.; Ferrao, L. F. V.; Munoz, P. R.
10.1101/2025.04.02.646913 — genomics — Posted on 2025-04-08
3808 The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism
Krawczyk, J.; O'Connor, W.; Vendramini, P.; Schell, M.; Biddinger, K. J.; Pengo, G.; Fougeray, T.; Aragam, K. G.; Haigis, M. C.; Lamers, W. H.; Tsai, L.; Biddinger, S.
10.1101/2025.04.03.647067 — physiology — Posted on 2025-04-08
3809 PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis
Su, H.; Sun, Y.; Guo, H.; Sun, C.-w.; Chen, Q.; Liu, S.; Li, A.; Gao, M.; Zhao, R.; Raffel, G.; Jin, J.; Qu, C.-K.; Yu, M.; Klug, C. A.; Zheng, Y. G.; Ballinger, S.; Kutny, M.; Long Zheng, X.; Chong, Z.; Senevirathne, C.; Gross, S.; Chen, Y.; Luo, M.; Zhao, X.
10.1101/2024.12.12.628174 — cancer biology — Posted on 2025-04-08
3813 Interpreting SNP heritability in admixed populations
Huang, J.; Kleman, N.; Basu, S.; Shriver, M. D.; Zaidi, A. A.
10.1101/2023.08.04.551959 — genetics — Posted on 2025-04-08
3815 Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes
Rust, R.; Bosworth, A.; Sagare, A. P.; Kisler, K.; Kim, Y.; Zhang, M.; Griffin, C.; Wang, Y.; Clementel, V.; Torres-Sepulveda, C.; TCW, J.; Zlokovic, B.; Coba, M.
10.1101/2023.06.26.546577 — neuroscience — Posted on 2025-04-08
3818 The heartbeat-evoked potential in young and older adults during attention orienting
Aprile, F.; Simoes, M.; Henriques, J.; de Carvalho, P.; Castelo-Branco, M.; Sel, A.; Ribeiro, M. J.
10.1101/2024.01.31.578137 — neuroscience — Posted on 2025-04-08
3822 Relaxin signaling is critical for virgin female reproductive physiology in Drosophila
Volonte, Y.; Heredia, F.; Zanini, R.; Menezes, J.; Perez, M. S.; Gualdino, M.; Lage, L.; Cruz, L. d. S.; Casimiro, A. P.; Garelli, A.; Gontijo, A. M.
10.1101/2025.04.03.647069 — physiology — Posted on 2025-04-08
3823 Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal Cancer
Jung, S.; Roy, R.; Zhao, Y. Q.; OConnell, T. M.; Wohlford, R. K.; Kim, D.; Hao, C.; Bellail, A.
10.1101/2025.04.08.647644 — cancer biology — Posted on 2025-04-08
3831 Striated fibre assemblins localise in the feeding groove of the 'typical excavate' Paratrimastix pyriformis
Heiss, A. A.; Fang, Y.-K.; Konupkova, A.; Zitek, J.; Novak, J.; Smida, A.; Zelena, M.; Svagr, E.; Miksatko, J.; Liebl, D.; Pena-Diaz, P.; Hampl, V.
10.1101/2024.03.29.587336 — microbiology — Posted on 2025-04-08
3832 B cell repertoire of children with atopic dermatitis exhibit altered IgE maturationassociated with allergic food sensitization
Gill, K.; Moore, C.; Nwogu, O.; Kroner, J. W.; Chang, W.-C.; Burkle, J.; Virolainen, S. J.; Stevens, M. L.; Baatyrbek kyzy, A.; Miraldi, E.; Biagini, J.; Devonshire, A. L.; Kottyan, L.; Schwartz, J. T.; Assa'ad, A.; Martin, L. J.; Andorf, S.; Hershey, G. K.; Roskin, K. M.
10.1101/2023.02.01.526538 — immunology — Posted on 2025-04-08
3833 Frequency-Specific Resting-State MEG Network Characteristics of Tinnitus Patients Revealed by Graph Learning
Sadeghi Shabestari, P.; Behjat, H. H.; Van De Ville, D.; Cederroth, C. R.; Edvall, N. K.; Naas, A.; Kleinjung, T.; Neff, P.
10.1101/2025.03.10.642147 — neuroscience — Posted on 2025-04-08
3836 Elucidating tissue and sub-cellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote
Sadanandom, A.; Banda, J.; Ghosh, S.; Roy, D.; Bishopp, A.; Jones, A.; Sharma, E.; Sue-Ob, K.; Clark, L.; Band, L. R.; Lilley, K. S.; Bennett, M. J.; Ingole, K.; De Lucas, M.; Bhosale, R.
10.1101/2025.04.08.647708 — plant biology — Posted on 2025-04-08
3838 Leveraging foundation models to dissect the genetic basis of cluster compactness and yield in grapevine
Sharma, S.; Munoz, J.; Torres-Lomas, E.; Lin, J.; Banayad, H.; Lupo, Y.; Nunez, V.; Gaspar, A.; Cantu, D.; Diaz-Garcia, L.
10.1101/2025.04.02.646891 — genetics — Posted on 2025-04-08
3841 Th1 cells express Tfh effector molecules and associate with B cells at the T-B borderfollowing viral infection
Chen, J. S.; Tierney, A. L.; Ojo, O. A.; Chow, R. D.; Song, E.; Mao, T.; Israelow, B.; Weinstein, J. S.; Williams, A.; Wilen, C. B.; Eisenbarth, S. C.
10.1101/2025.04.02.646697 — immunology — Posted on 2025-04-08
3842 Data-driven mathematical modelling explains altered timing of EARLY FLOWERING 3 in the wheat circadian oscillator
Upadhyay, A.; Rowland-Chandler, J.; Stewart-Wood, J.; Pingarron-Cardenas, G.; Tokuda, I. T.; Webb, A. A.; Locke, J. C.
10.1101/2025.04.08.644541 — plant biology — Posted on 2025-04-08
3845 A modular, Galaxy-based immunopeptidogenomic (iPepGen) analysis pipeline for discovery, verification, and prioritization of candidate cancer neoantigen peptides
Mehta, S.; Wagner, R.; Do, K. T.; Johnson, J. E.; Yu, F.; Jubenville, T.; Richards, K.; Coleman, S.; Popescu, F. E.; Nesvizhskii, A. I.; Largaespada, D. A.; Jagtap, P. D.; Griffin, T. J.
10.1101/2025.04.07.647596 — bioinformatics — Posted on 2025-04-08
3846 High-resolution reconstruction of cell-type specific transcriptional regulatory processes from bulk sequencing samples
Yao, L.; Shah, S. R.; Ozer, A.; Zhang, J.; Pan, X.; Xia, T.; Fangal, V.; Leung, A. K.-Y.; Wei, M.; Lis, J.; Yu, H.
10.1101/2025.04.02.646189 — bioinformatics — Posted on 2025-04-08
3853 Non-invasive skin topical delivery of hyaluronan
Feng, W.; Ye, J.; Li, S.; Shao, S.; Xiang, J.; Piao, Y.; Wei, Q.; Tang, J.; Zhou, Z.; Shen, Y.
10.1101/2025.04.03.646962 — bioengineering — Posted on 2025-04-08
3854 Evaluation of adipose-derived stromal cell infused modified-hyaluronic acid scaffolds for post cancer breast reconstruction
Challapalli, R. S.; O'Dwyer, J.; McInerney, N.; Kerin, M. J.; Duffy, G. P.; Dolan, E. B.; Dwyer, R. M.; Lowery, A. J.
10.1101/2025.04.03.646623 — bioengineering — Posted on 2025-04-08
3864 Newly Sequenced Genomes Reveal Patterns of Gene Family Expansion in select Dragonflies (Odonata: Anisoptera)
Tolman, E. R.; Beatty, C. D.; Frandsen, P. B.; Bush, R. J.; Burchim, O. R.; Driever, E. S.; Harding, K. M.; Jordan, D.; Kohli, M. K.; Park, J.; Park, S.; Reyes, K.; Rosario, M.; Ryu, J. L.; Wade, V.; Ware, J. L.; Suvorov, A.
10.1101/2023.12.11.569651 — evolutionary biology — Posted on 2025-04-08
3866 The DNA damage response and RNA Polymerase II regulator Def1 has posttranscriptional functions in the cytoplasm
Akinniyi, O. T.; Sebastian, A.; Kulkarni, S.; Hribal, M. M.; Keller, C. A.; Giardine, B.; Albert, I.; Reese, J. C.
10.1101/2024.09.16.613278 — molecular biology — Posted on 2025-04-08
3868 Mobile genetic elements that shape microbial diversity and functions in thawing permafrost soils
Guo, J.; Aroney, S.; Dominguez-Huerta, G.; Smith, D.; Vik, D.; Ansah, C. O.; Pratama, A. A.; Solonenko, S.; Tian, F.; Howard-Varona, C.; Zhong, Z.; Fofana, A.; Smith, G.; Hodgkins, S. B.; Cronin, D.; EMERGE Field Teams 2010-2019, ; EMERGE Coordinators, ; Woodcroft, B. J.; Tyson, G. W.; Rich, V. I.; Sullivan, M. B.; Roux, S.; Bagby, S. C.
10.1101/2025.02.12.637893 — microbiology — Posted on 2025-04-08
3869 Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis.
Kimura, N.; Wong, M. C.; Hardisty, G.; Higgins, B.; Huang, P.-C.; Besh, M.; Kendall, T. J.; Rossi, A.; Ramachandran, P.; Patten, D.; Shetty, S.; Anderson, G.; Withers, D.; Tsuchiya, A.; Terai, S.; Lu, W.-Y.
10.1101/2025.04.02.646748 — immunology — Posted on 2025-04-08
3870 Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues
Murakami, T. C.; Belenko, N.; Dennis, G.; Wang, C.; Siantoputri, M. E.; Maeda, Y.; Pressl, C.; Heintz, N.
10.1101/2025.02.24.639965 — neuroscience — Posted on 2025-04-08
3871 Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.
Kałamała, P.; Ware, N.; Fabiani, M.; Michie, P. T.; Hunter, M.; Wade, A.; Simpson, F.; Mellow, M. L.; Low, K.; Keage, H.; Gratton, G.; Smith, A. E.; Karayanidis, F.
10.1101/2025.04.06.646611 — neuroscience — Posted on 2025-04-08
3873 Organ-level Gene Regulatory Network models enable the identification of central transcription factors in Solanum lycopersicum
Fernandez, J. D.; Navarro-Paya, D.; Santiago, A.; Cerda, A.; Canan, J.; Contreras-Riquelme, S.; Moyano, T. C.; Melet, L.; Johnson, N. R.; Alvarez, J. M.; Canales, J.; Matus, J. T.; Vidal, E. A.
10.1101/2025.03.26.645553 — systems biology — Posted on 2025-04-08
3874 A leaf phenomics approach to estimating below-ground traits in North American Licorice
Harris, Z. N.; Tran, V.; Piotter, E.; Hanlon, M. T.; Rubin, M. J.; Miller, A. J.
10.1101/2025.04.07.647639 — plant biology — Posted on 2025-04-08
3875 A network of RS splicing regulatory proteins controls light-dependent splicing and seedling development
Saile, J.; Walter, H.; Denecke, M.; Lederer, P.; Schuetz, L.; Hiltbrunner, A.; Lepp, K.; Lobato-Gil, S.; Beli, P.; Wachter, A.
10.1101/2025.04.07.646831 — plant biology — Posted on 2025-04-08
3876 Robust non-invasive detection of hyperglycemia in mouse models of metabolic dysregulation: the novel Urination Index biomarker
Brachs, S.; Dall, M.; Zimbalski, L.-K.; Santin, Y.; Oeing, C.; Mai, K.; Parini, A.; Gaburro, S.; Nielsen, T. S.
10.1101/2025.04.02.646666 — physiology — Posted on 2025-04-08
3877 SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging
Liu, F.; He, R.; Sheeley, T.; Scheiblin, D.; Lockett, S. J.; Ridnour, L. A.; Wink, D. A.; Jensen, M.; Cortner, J.; Zaki, G.
10.1101/2025.04.02.646782 — bioinformatics — Posted on 2025-04-08
3879 Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses
Faria Fonseca, B.; Wong-Ng, J.; Connor, M.; Mary, H.; Kim, M. H.; Yim, R.; BONDET, V.; Michel, V.; Strick Marchand, H.; Di Santo, J. P.; Duffy, D.; Hamon, M. A.; Sauvonnet, N.; Chakrabarti, L. A.; Gobaa, S.
10.1101/2025.03.31.644992 — bioengineering — Posted on 2025-04-08
3880 Beyond the known cuts: trypsin specificity in native proteins
Gaspar, M.; Sokolova, B.; Saei, A.; Marques, J. C.; Zubarev, R. A.
10.1101/2025.04.04.647035 — biochemistry — Posted on 2025-04-08
3881 BromoCatch: a self-labelling tag platform for protein analysis and live cell imaging
Rodriguez-Rios, M.; Craigon, C. G.; Nakasone, M. A.; Bond, A. G.; Dorward, M.; Edmonds, A. K.; Norley, M. C.; Arnold, R. E.; Wood, P. M.; Reynolds, S. J.; Cresser-Brown, J. O.; Marsh, G. P.; Maple, H. J.; Ciulli, A.
10.1101/2025.04.07.647551 — biochemistry — Posted on 2025-04-08
3883 Comparative analysis of mammalian adaptive immune loci revealed spectacular divergence and common genetic patterns
Pospelova, M.; Voss, K.; Zamyatin, A.; Watson, C. T.; Koepfli, K.-P.; Bankevich, A.; Pennell, M.; Safonova, Y.
10.1101/2025.04.01.646651 — genomics — Posted on 2025-04-08
3889 A novel critic signal in identified midbrain dopaminergic neurons of mice training in operant tasks
Matsumoto, J.; Oberto, V.; Pompili, M. N.; Todorova, R.; Papaleo, F.; Nishijo, H.; Venance, L.; Vandecasteele, M.; Wiener, S. I.
10.1101/2024.05.06.592735 — neuroscience — Posted on 2025-04-08
3890 Differential Effects of Short-term and Long-term Deep Brain Stimulation on Striatal Neuronal Excitability in a Dystonia Animal Model
Heerdegen, M.; Franz, D.; Neubert, V.; Kragelund, F.; Sellmann, T.; Werner-Schmolling, C.; Starke, J.; Spiliotis, K.; Richter, F. A.; Richter, A.; Kohling, R.
10.1101/2025.04.07.647541 — neuroscience — Posted on 2025-04-08
3891 Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI
Spencer, A. P. C.; Nguyen-Duc, J.; de Riedmatten, I.; Szczepankiewicz, F.; Jelescu, I. O.
10.1101/2024.10.01.615823 — neuroscience — Posted on 2025-04-08
3893 Estimating the replicability of Brazilian biomedical science
Amaral, O. B.; Carneiro, C. F. D.; Neves, K.; Sampaio, A. P. W.; Gomes, B. V.; Abreu, M. B. d.; Tan, P. B.; Mota, G. P. S.; Goulart, R. N.; Fernandes, N. R. d. S.; Linhares, J. H.; Ibelli, A. M. G.; Sebollela, A.; Andricopulo, A. D.; Carvalho, A. A. V. d.; Silva, A. P. e.; Souza, A. S. O.; Lima, A. C. C. d.; Sousa, A. M. d.; Birbrair, A.; Borbely, A. U.; Machado, A. M.; Costa, A. d. C.; Vasconcelos, A. P. d.; Silva, A. H. B. d. L.; Souza, A. d.; Herrmann, A. P.; Bastos, A. P. A.; Nunes, A. C. C.; Castrucci, A. M. d. L.; Paula, A. B. R.; Waltrick, A. P. F.; Macedo, A. G. F. d.; Mecawi, A. S.; R
10.1101/2025.04.02.645026 — scientific communication and education — Posted on 2025-04-08
3894 Semilichen - an unjustly neglected symbiotic system between green biofilms and true lichens
Vondrak, J.; Svoboda, S.; Riha, P.; Hauser, T.; Kantnerova, V.; Skaloud, P.; Kubasek, J.
10.1101/2024.12.10.626781 — physiology — Posted on 2025-04-08
3895 Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)
Schwarz, P. F.; Perhal, A. F.; Preglej, T.; Breit, L.; Schmetterer, K. G.; Grienke, U.; Janneschütz, J.; Chen, Y.; Rochel, N.; Kirchmair, J.; Schützenmeister, N.; Rollinger, J. M.; Bonelli, M.; Dirsch, V. M.
10.1101/2025.04.01.646598 — pharmacology and toxicology — Posted on 2025-04-08
3901 Isolation and primary culture of Octopus vulgaris cells: Assessment of their proliferative capacity
Galindo, A.; Coello, R.; Banos, I.; Ramos-Trujillo, E.; Morales, A.; Arrieta, J. M.; Rodriguez, C.; Almansa, E.
10.1101/2025.04.07.647602 — cell biology — Posted on 2025-04-08
3902 Using 3D Invasion properties of RCC Cell Lines In Vitro to predict their Metastatic Potential In Vivo
Cesana, B.; Nemoz-Billet, L.; Azemard, V.; Pillet, C.; Bigot, E.; Chaumontel, N.; Descotes, J.-L.; OSMANI, O.; GOETZ, J. G.; Cochet, C.; Filhol, O.
10.1101/2025.04.07.647527 — cell biology — Posted on 2025-04-08
3904 AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes
Srivastava, S. P.; Kopasz-Gemmen, O.; Kunamneni, A.; Thurnman, A.; Ozukan, E.; Swaroop, V.; Yoshida, S.; Hong, S.; Inoki, K.
10.1101/2025.04.07.647592 — cell biology — Posted on 2025-04-08
3906 Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins
Reig-Viader, R.; del Castillo-Berges, D.; Burgas-Pau, A.; Arco-Alonso, D.; Zerpa-Rios, O.; Ramos-Vicente, D.; Picanol, J.; Castellanos, A.; Soto, D.; Roher, N.; Sindreu, C.; Bayes, A.
10.1101/2024.04.04.588090 — neuroscience — Posted on 2025-04-08
3907 A hydrophobic core in the coiled-coil domain is essential for NRC resistosome function
Wang, H.-Y.; Yuen, E. L. H.; Lee, K.-T.; Goh, F.-J.; Bozkurt, T. O.; Wu, C.-H.
10.1101/2025.01.21.634219 — plant biology — Posted on 2025-04-08
3908 DeNoFo: a file format and toolkit for standardised, comparable de novo gene annotation
Dohmen, E.; Aubel, M.; Eicholt, L. A.; Roginski, P.; Luria, V.; Karger, A.; Grandchamp, A.
10.1101/2025.03.31.644673 — bioinformatics — Posted on 2025-04-08
3909 Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22
Yamaguchi, T.; Okatsu, K.; Kubota, M.; Mitsumori, A.; Yamagata, A.; Fukata, Y.; Fukata, M.; Shibata, M.; Fukai, S.
10.1101/2025.01.06.631603 — biochemistry — Posted on 2025-04-08
3915 In-vivo Efficacy of a Phage Cocktail Therapy that Targets ESBL-producing Klebsiella species that cause Urinary Tract Infections
Jariah, R. O. A.; Schofield, J.; West, K.; Michniewski, S.; Jameson, E.; Onions, L.; Saravanan, A.; Yesilkaya, H.; Millard, A. D.; Clokie, M. R. J.; Haines, M. E. K.
10.1101/2025.04.01.646603 — microbiology — Posted on 2025-04-08
3916 Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling
Hartenian, E.; Bernard, E. M.; Ammirati, G.; Leloup, H. B.; Agustoni, M.; Bissegger, L.; Santos, J. C.; Glück, I.; Mari, S.; Sieben, C.; Petrilli, V.; Monnier, S.; Müller, D.; Broz, P.
10.1101/2024.10.29.620849 — immunology — Posted on 2025-04-08
3917 Ternary Neurexin-T178-PTPR complexes represent a presynaptic core-module of neuronal synapse organization
Thivaios, S.; Schwenk, J.; Brechet, A.; Boudkkazi, S.; Sethumadhavan, N.; Henneken, P.; Miura, E.; Hayashi, A.; Kocylowski, M. K.; Haupt, A.; Kaminski, D.; Schreiner, D.; van den Broucke, J.-B.; Kulik, A.; Schulte, U.; Sterky, F. H.; Yuzaki, M.; Scheiffele, P.; Fakler, B.
10.1101/2024.07.16.603715 — neuroscience — Posted on 2025-04-08
3918 The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
Hanif, S. Z.; Au, C. C.; Torregroza, I.; Kutz, C.; Jannath, S.; Fabiha, T.; Bhinder, B.; Washburn, M.; Devost, D.; Liu, S.; Bhardwaj, P.; Evans, T.; Anand, P. K.; Tarran, R.; Palikhe, S.; Elemento, O.; Dow, L. E.; Blenis, J.; Hebert, T.; Brown, K. A.
10.1101/2024.07.22.604482 — cancer biology — Posted on 2025-04-08
3920 Repurposing without Reinventing the Wheel - Ensemble Models for Differential Analysis
Chatterjee, S.; Paul, E.; Liu, Z.; Gao, J.; Basak, P.; Bhattacharyya, A.; Banerjee, C.; Mallick, H.
10.1101/2025.04.07.647549 — bioinformatics — Posted on 2025-04-08
3921 Photocrosslinkable and biodegradable hydrogels for the controlled delivery of exosomes
Ayala-Mar, S.; Jeon, O.; Chacon-Ponce, P.; Gonzalez-Valdez, J.; Alsberg, E. A.
10.1101/2025.04.01.646472 — bioengineering — Posted on 2025-04-08
3922 PISA: a versatile interpretation tool for visualizing cis-regulatory rules in genomic data
Zeitlinger, J.; McAnany, C. E.; Weilert, M.; Kamulegeya, F.; Mehta, G.; Gardner, J. M.; Kundaje, A.
10.1101/2025.04.07.647613 — genomics — Posted on 2025-04-08
3923 A novel, wave-shaped profile of germline selection of pathogenic mtDNA mutations is discovered by bypassing a classical statistical bias.
Franco, M.; Cote-LHeureux, A.; Fleischmann, Z.; Chen, Z.; Khrapko, M.; Vyshedskiy, B.; Braverman, M.; Popadin, K.; Pickett, S.; Woods, D. C.; Tilly, J.; Turnbull, D.; Khrapko, K.
10.1101/2023.11.21.568140 — genomics — Posted on 2025-04-08
3924 Reshaping epistatic network modules enhances wheat yield potential
Yin, M.; Han, H.; Liu, W.; Kong, L.; Li, X.; Ji, W.; Wu, J.; Deng, G.; Dong, H.; Zhang, J.; Zhou, S.; Zhang, Z.; Hou, Y.; Wang, H.; Zhao, C.; Li, X.; Luo, Q.; Guo, X.; Yang, X.; Ling, H.-Q.; He, F.; Li, L.
10.1101/2025.04.01.646715 — genetics — Posted on 2025-04-08
3926 Non-linear Age-related Change in Human Interleukin-11 and the receptor subunit alpha DNA Methylation
Shimura, A.; Dwaraka, V. B.; Yamanishi, K.; Seki, T.; Nishiguchi, T.; Aoyama, B.; Ishii, T.; Phuong, N. J.; Gorantla, N.; Nguyen, H. D.; Santiago, T.; Nishitani, S.; Smith, R.; Shinozaki, G.
10.1101/2025.04.01.646733 — genetics — Posted on 2025-04-08
3928 Scrib organizes cortical actomyosin clusters to maintain adherens junctions and angiogenic sprouting
Mayo, L. N.; Duong, F.; Mompeon, A.; Jacobs, K. A.; Iruela-Arispe, M. L.; Kutys, M. L.
10.1101/2025.04.01.645927 — cell biology — Posted on 2025-04-08
3930 Oral antigen exposure under co-stimulation blockade generates Treg cells to establish immune tolerance despite prior sensitization
Arai, M.; Kawakami, R.; Nakamura, Y.; Naito, Y.; Motooka, D.; Sugimoto, A.; Kimoto, T.; Ohkura, N.; Mikami, N.; Sakaguchi, S.
10.1101/2025.04.02.646742 — immunology — Posted on 2025-04-08
3931 Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing
Somech, E.; Halder, D.; Spitzer, A.; Barbolin, C.; Tyler, M.; Halperin, R.; Biton, M.; Tirosh, A.; Tirosh, I.
10.1101/2024.07.29.605642 — cancer biology — Posted on 2025-04-08
3932 Datavzrd: Rapid programming- and maintenance-free interactive visualization and communication of tabular data
Wiegand, F. C.; Lähnemann, D.; Mölder, F.; Uzuner, H.; Prinz, A.; Schramm, A.; Köster, J.
10.1101/2025.04.03.647146 — bioinformatics — Posted on 2025-04-08
3938 Small-molecule modulation of Beta-arrestins
Kahsai, A. W.; Pakharukova, N.; Kwon, H. Y.; Shah, K. S.; Liang-Lin, J. G.; del Real, C. T.; Shim, P. J.; Lee, M. A.; Ngo, V. A.; Shreiber, B. N.; Liu, S.; Schwalb, A. M.; Espinoza, E. F.; Thomas, B. N.; Kunzle, C. A.; Smith, J. S.; Wang, J.; Kim, J.; Zhang, X.; Rockman, H. A.; Thomsen, A. R. B.; Rein, L. A. M.; Shi, L.; Ahn, S.; Masoudi, A.; Lefkowitz, R. J.
10.1101/2024.12.27.630464 — biochemistry — Posted on 2025-04-08
3940 GUIDE deconstructs genetic architectures using association studies
Lazarev, D.; Chau, G.; Bloemendal, A.; Churchhouse, C.; Neale, B.
10.1101/2024.05.03.592285 — genetics — Posted on 2025-04-08
3949 Le Petit Prince (LPP) Multi-talker: Naturalistic 7T fMRI and EEG Dataset
Li, J.; Wang, Q.; Wang, Y.; Wang, C.; Ma, Z.; Xu, R.; Feng, S.; Jiang, X.; Meng, Z.
10.1101/2025.04.03.646958 — neuroscience — Posted on 2025-04-08
3950 Atypical Alpha Oscillatory EEG Dynamics in Children with Angelman Syndrome
Dickinson, A. H.; Bowen-Kauth, S.; Shide, J. J.; Youngkin, A. E.; Hosamane, N. S.; McNair, C. A.; Ryan, D. P.; Chu, C. J.; Sidorov, M. S.
10.1101/2025.04.03.647110 — neuroscience — Posted on 2025-04-08
3952 The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training
Song, R. W.; Min, J.; Wang, S.; Goodale, S. E.; Rogge-Obando, K.; Yang, R.; Yoo, H. J.; Nashiro, K.; Chen, J. E.; Mather, M.; Chang, C.
10.1101/2025.04.04.647252 — neuroscience — Posted on 2025-04-08
3954 A hydrophobic core in the coiled-coil domain is essential for NRC resistosome function
Wang, H.-Y.; Yuen, E. L. H.; Lee, K.-T.; Goh, F.-J.; Bozkurt, T. O.; Wu, C.-H.
10.1101/2025.01.21.634219 — plant biology — Posted on 2025-04-08
3955 PAC: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures
Anderson, L. L.; Kahlig, K. M.; Barker-Haliski, M. L.; Hannigan, B.; Toop, H.; Matthews, L. G.; French, J.; White, H. S.; Souza, M.; Petrou, S.
10.1101/2025.04.04.647239 — pharmacology and toxicology — Posted on 2025-04-08
3956 COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2
West, G.; Morse, R.; Sievers, B. L.; Abdullahi, A.; Kamelian, K.; Cheng, M.; Bioresource, C. N.; Stewart, D.; David, D.; Robertson, D. L.; Lytras, S.; Wilson, S. J.; Rihn, S. J.; Gupta, R. K.
10.1101/2025.04.04.647203 — microbiology — Posted on 2025-04-07
3957 Intranasal sarbecovirus vaccine booster elicits cross-clade, durable and protective systemic and mucosal immunity
CHEANG, N. Y. Z.; YAP, W. C.; TULLETT, K. M.; Qian, X.; TAN, P. S.; Purushotorman, K.; TAN, W. Y.; MAH, S. Y. Y.; MacAry, P. A.; TAN, C. W.; Lahoud, M. H.; ALONSO, S.
10.1101/2025.04.04.647326 — immunology — Posted on 2025-04-07
3960 Gene Novelties in Amphioxus Illuminate the Early Evolution of Cephalochordates
Xiong, Q.; Yang, K. Y.; Zeng, X.; Wang, M.; Ng, P. K.-S.; Zhou, J.-W.; Ng, J. K.-W.; Law, C. T.-Y.; Du, Q.; Xu, K.; Mao, B.; Tsui, S. K.-W.
10.1101/2022.05.18.492404 — evolutionary biology — Posted on 2025-04-07
3961 Direct visualization and tracing of DNA fold in Drosophila embryo
Fatmaoui, F.; Carrivain, P.; Taiki, F.; Grewe, D.; Hagen, W. J.; Jacob, B.; Victor, J.-M.; Leforestier, A.; Eltsov, M.
10.1101/2022.08.16.502515 — cell biology — Posted on 2025-04-07
3962 Evolution and instability of human centromeres are accelerated by heterochromatin boundary loss and CENP-A overexpression
Mahlke, M. A.; Lumerman, L.; Nath, P.; Chittenden, C.; Hoyt, S.; Koeppel, J.; Xu, Y.; Raphael, R.; Zaffina, K.; Hook, P. W.; Timp, W.; Miga, K. H.; Campbell, P.; O'Neill, R. J.; Altemose, N.; Nechemia-Arbely, Y.
10.1101/2025.02.03.636285 — cell biology — Posted on 2025-04-07
3964 Global Metagenomics Reveals Hidden Protist Diversity
Gutierrez, M. F. R.; Krinos, A. I.; Alcala, X. M.; Burns, J. A.; Stepanauskas, R.; Woyke, T.; Schulz, F.
10.1101/2025.03.26.645542 — microbiology — Posted on 2025-04-07
3965 Measuring the functional complexity of nanoscale connectomes: polarity matters
Wang, Q.; Randel, N.; Yin, Y.; Shand, C.; Strange, A.; Winding, M.; Cardona, A.; Zlatic, M.; Vogelstein, J.; Priebe, C.
10.1101/2024.09.24.614724 — neuroscience — Posted on 2025-04-07
3970 Viral community diversity in the rhizosphere of the foundation salt marsh plant Spartina alterniflora
Du Plessis, I.; Snyder, H.; Calder, R.; Rolando, J.; Kostka, J. E.; Weitz, J. S.; Dominguez-Mirazo, M.
10.1101/2025.04.03.647062 — genomics — Posted on 2025-04-07
3971 Quantifying plasmid movement in drug-resistant Shigella species using phylodynamic inference
Müller, N. F.; Wick, R. R.; Judd, L. M.; Williamson, D. A.; Bedford, T.; Howden, B.; Duchene, S.; Ingle, D. J.
10.1101/2022.10.27.514108 — evolutionary biology — Posted on 2025-04-07
3973 The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions
De, S.; Busch, L. M.; Burchhardt, G.; Gesell Salazar, M.; Schlueter, R.; Steil, L.; Voelker, U.; Hammerschmidt, S.
10.1101/2025.04.07.647550 — microbiology — Posted on 2025-04-07
3976 Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification
Vishwanatha, A.; Zhang, X.; Liu, Y. J.; Leung, A.; Herring, M.; Chan, A.; Calhoun, S.; Deitsch, K. W.; Kirkman, L.
10.1101/2025.04.07.647301 — microbiology — Posted on 2025-04-07
3978 Genomic insights into polysaccharide substrate utilization and novel genera resource mining in macroalgal epiphytic bacteria
Liu, T.; Zhou, H.-Y.; Zhang, H.-Z.; Wang, F.-Q.; Liu, Y.-Z.; Teng, J.-H.; Fan, S.-J.; Lu, D.-C.; Du, Z.
10.1101/2025.04.07.647558 — microbiology — Posted on 2025-04-07
3979 Enterovirus D68 infection of human inducible pluripotent stem cell-derived skeletal muscles resulted in structural destruction, loss of muscle function and hampered muscle regeneration
Laksono, B. M.; Bergsma, A. J.; Iuliano, A.; Veldhoen, D. Y.; van Nieuwkoop, S.; Boter, M.; Leijten, L.; Bauer, L.; Munnink, B. B. O.; Pijnappel, W. W. M. P.; van Riel, D.
10.1101/2025.04.07.647509 — microbiology — Posted on 2025-04-07
3981 Bacteria with antibacterial activities isolated from Magallana gigas microbiota as potential probiotics against Vibrio aestuarianus infections in oyster farming
Dantan, L.; Travers, M.-A.; Degremont, L.; Morga, B.; Carcassonne, P.; Mege, M.; Fleury, Y.; Petton, B.; Maurouard, E.; Allienne, J.-F.; Courtay, G.; Romatif, O.; Lami, R.; Intertaglia, L.; Gueguen, Y.; Vidal-Dupiol, J.; Cosseau, C.; Toulza, E.
10.1101/2025.04.07.647571 — microbiology — Posted on 2025-04-07
3982 The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity
Itani, A.; Motomura, H.; Oda, K.; Yamashita, H.; Sakai, K.; Kusumoto, K.-i.; Shigeto, S.; Ichikawa, T.; Mubarak, H. M.; Fukuma, T.; Katayama, T.; Maruyama, J.-i.; Masuo, S.; Takaya, N.; Takeshita, N.
10.1101/2025.04.06.647446 — microbiology — Posted on 2025-04-07
3987 Knockout of P2Y12 receptor facilitates microglia-neuron body-to-body interactions and accelerates prion disease
Makarava, N.; Safadi, T.; Bocharova, O.; Mychko, O.; Pandit, N. P.; Molesworth, K.; Eyo, U. B.; Baskakov, I. V.
10.1101/2025.04.07.647619 — neuroscience — Posted on 2025-04-07
3988 Projection-TAGs enable multiplex projection tracing and multi-modal profiling of projection neurons
Yang, L.; Liu, F.; Hahm, H.; Okuda, T.; Li, X.; Zhang, Y.; Kalyanaraman, V.; Heitmeier, M. R.; Samineni, V. K.
10.1101/2024.04.24.590975 — neuroscience — Posted on 2025-04-07
3990 Harmonizing Inter-Site Differences in T1-Weighted Images Using CycleGAN
Shimizu, M.; Yamashita, Y.; Yamaguchi, H.; Oishi, N.; Takahashi, H.; Sugihara, G.
10.1101/2025.04.07.646944 — neuroscience — Posted on 2025-04-07
3991 High-throughput measurements of neuronal activity in single human iPSC-derived glutamate neurons
Gameiro-Ros, I. M.; Tengolics, A. J.; Prytkova, I.; Kamarajan, C.; Pang, Z. P.; Goate, A. M.; Hart, R. P.; Slesinger, P. A.
10.1101/2025.04.07.646449 — neuroscience — Posted on 2025-04-07
3993 Differential Effects of Short-term and Long-term Deep Brain Stimulation on Striatal Neuronal Excitability in a Dystonia Animal Model
Heerdegen, M.; Franz, D.; Neubert, V.; Kragelund, F.; Sellmann, T.; Werner-Schmolling, C.; Starke, J.; Spiliotis, K.; Richter, F. A.; Richter, A.; Kohling, R.
10.1101/2025.04.07.647541 — neuroscience — Posted on 2025-04-07
3996 Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild Traumatic Brain Injury
Munoz-Ballester, C.; Leitzel, O. J.; Golf, S. R.; Phillips, C. M.; Zeitz, M. J.; Pandit, R.; Wash, E.; Donohue, J. V.; Smyth, J. W.; Lamouille, S.; Robel, S.
10.1101/2024.11.12.623104 — neuroscience — Posted on 2025-04-07
3997 The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation
Romani, F.; Bonter, I.; Rebmann, M.; Takahashi, G.; Guzman-Chavez, F.; De Batte, F.; Hirakawa, Y.; Haseloff, J.
10.1101/2025.03.12.642684 — plant biology — Posted on 2025-04-07
3998 Acid-Sensing Ion Channel 1a Deficiency Drives Endocrine Hypertension in Male Mice
Garcia, S. M.; Tuineau, M. N.; DeLeon, X. A.; Detweiler, N. D.; Tamang, S.; Kanagy, N. L.; Gonzalez Bosc, L. V.; Resta, T. C.; Naik, J. S.; Jernigan, N. L.
10.1101/2025.03.25.645371 — physiology — Posted on 2025-04-07
3999 Learning the cellular origins of cancer using single-cell chromatin landscapes
Bairakdar, M. D.; Giotti, B.; Lee, W.; Stancl, P.; Wagenblast, E.; Hambardzumyan, D.; Polak, P.; Karlic, R.; Tsankov, A.
10.1101/2025.04.06.646131 — cancer biology — Posted on 2025-04-07
4003 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)
Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.
10.1101/2024.12.06.627158 — genomics — Posted on 2025-04-07
4004 Regulation of epigenetics and chromosome structure by human ORC2
Su, Z.; Tian, M.; Shibata, E.; Shibata, Y.; Yang, T.; Wang, Z.; Jin, F.; Zang, C.; Dutta, A.
10.1101/2024.12.18.629220 — genomics — Posted on 2025-04-07
4008 Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development
Chen, M. y.; Lv, J. j.; Zhang, Q.; Gong, Q.; Zhao, T.; Chen, Z. p.; Xu, H. s.; Zhou, N.; Du, J.; Chen, X. p.; Ke, Y. w.
10.1101/2025.04.05.647413 — developmental biology — Posted on 2025-04-07
4009 Unlocking the Distinct Roles of the Three Mammalian VDAC Isoforms in Mitochondrial Respiration and Cancer Cell Metabolism
Rajendran, M.; Rosencrans, W. M.; Fitzgerald, W.; Huynh, D.; Beyene, B. G.; Quan, B.; Hwang, J.; Bautista, N. A.; Chou, T.-F.; Bezrukov, S. M.; Rostovtseva, T. K.
10.1101/2025.02.20.639106 — cell biology — Posted on 2025-04-07
4010 Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Dietrich, M.; Chmielewski, J.; Chan, L.-J.; Tan, L. L.; Adair, A.; Lyons, F.; Gabriela, M.; Lopaticki, S.; Dite, T.; Dagley, L.; Pazzagli, L.; Gupta, P.; Kamil, M.; Vaughan, A. M.; Rojrung, R.; Abraham, A.; Mazhari, R.; Longley, R. J.; Zeglinski, K.; Gouil, Q.; Mueller, I.; Fabb, S.; Shandre-Mugan, R.; Pouton, C. W.; Glukhova, A.; Shakeel, S.; Tham, W.-H.
10.1101/2025.02.13.638205 — microbiology — Posted on 2025-04-07
4012 Inactivation of the Fusobacterium nucleatum Rnf complex reduces FadA-mediated amyloid formation and tumor development
Britton, T. A.; Lee, J. H.; Chang, C.; Bhat, A.; Chen, Y.-W.; Ali, R. M.; Wu, C.; Das, A.; Ton-That, H.
10.1101/2025.04.03.647037 — microbiology — Posted on 2025-04-07
4013 Enteric Viruses and Free-Living Amoebae: Protozoa as Potential Reservoirs and Transport Vessels for human Norovirus and Adenovirus
Leifels, M.; Dey, R.; Wiedmeyer, A.; Cheng, D.; Kolm, C.; Wu, F.; Sirikanchana, K.; Farnleitner, A. H.; Ashbolt, N. J.
10.1101/2025.04.07.647535 — microbiology — Posted on 2025-04-07
4014 Identifying Modulators of the Post-Antibiotic Effect
Gilberti, A. L.; Tu, M. M.; Rachwalski, K.; Ali, M. I.; Cohen, S. A.; Akoglu, M.; Pollard-Kerning, A. C.; Tolentino Collado, J.; Sabbah, A.; Abou Said, F.; Dela, P.; Walker, S. G.; Haley, J. D.; Brown, E. D.; Tonge, P. J.
10.1101/2025.04.06.647494 — microbiology — Posted on 2025-04-07
4015 Cell-type specific repertoire of responses to natural scenes in primate retinal ganglion cells
Kling, A.; Brackbill, N.; Rhoades, C. E.; Gogliettino, A.; Sher, A.; Litke, A.; Chichilnisky, E. J.
10.1101/2025.04.07.647118 — neuroscience — Posted on 2025-04-07
4016 Learning evoked centrality dynamics in the schizophrenia brain: Entropy, heterogeneity and inflexibility of brain networks
Bhatt, D.; Kopchick, J.; Abel, C. C.; Khatib, D.; Thomas, P.; Rajan, U.; Zajac-Benitez, C.; Haddad, L.; Amirsadri, A.; Stanley, J.; Diwadkar, V.
10.1101/2025.04.05.647398 — neuroscience — Posted on 2025-04-07
4019 Optogenetic disruption of neural dynamics in the prefrontal cortex impaired spatial learning
Negron-Oyarzo, I.; Dib, T.; Chacana-Veliz, L.; Barria, D.; Morales-Weil, K.; Fuenzalida, M.; Espinosa, N.
10.1101/2025.04.07.647582 — neuroscience — Posted on 2025-04-07
4022 Visual pathway origins: an electron microscopic volume for connectomic analysis of the human foveal retina
Kim, Y. J.; Packer, O.; Macrina, T.; Pollreisz, A.; Curcio, C. A.; Lee, K.; Kemnitz, N.; Ih, D.; Nguyen, T.; Lu, R.; Popovych, S.; Halageri, A.; Bae, J. A.; Strout, J.; Gerhard, S.; Smith, R. G.; Martin, P. R.; Grünert, U.; Dacey, D.
10.1101/2025.04.05.647403 — neuroscience — Posted on 2025-04-07
4023 Optimizing Biophysical Large-Scale Brain Circuit Models With Deep Neural Networks
Zeng, T.; Tian, F.; Zhang, S.; Li, X.; Tan, A. P.; Larsen, B.; Gur, R. C.; Gur, R. E.; Moore, T. M.; Satterthwaite, T. D.; Deco, G.; Holmes, A. J.; Yeo, B. T. T.
10.1101/2025.04.07.647497 — neuroscience — Posted on 2025-04-07
4024 Nociceptor clock genes control excitability and pain perception in a sex- and time-dependent manner
Brecier, A.; Bannerman, C. A.; Xie, Y.-F.; Dedek, C.; Zacharias, A. M.; O'Connor, C. D.; Miller, S. D.; Ballantyne, L. L.; Du Bois, J.; Duan, Q.; Prescott, S. A.; Ghasemlou, N.
10.1101/2025.04.07.646998 — neuroscience — Posted on 2025-04-07
4025 Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay
Olsen, A.-K.; Ma, X.; Zheng, C.; Dahl, H.; Dirven, Y.; Boisen, A. M.; Sharma, A.; Eide, D. M.; Brunborg, G.
10.1101/2024.12.22.624648 — pharmacology and toxicology — Posted on 2025-04-07
4027 Autonomous learning of pathologists' cancer grading rules
Nguyen, T. H.; Panwar, V.; Jarmale, V.; Perny, A.; Dusek, C.; Cai, Q.; Kapur, P. H.; Danuser, G.; Rajaram, S.
10.1101/2025.03.18.643999 — bioinformatics — Posted on 2025-04-07
4028 Stoichiometric Insights into SARS-CoV-2 Spike-ACE2 Binding Across Variants
Akinwumi, I. A.; Bheemireddy, S.; CHALOIN, L.; Perez, S.; Khakzad, H.; Maigret, B.; Karami, Y.
10.1101/2025.04.04.647209 — bioinformatics — Posted on 2025-04-07
4029 A mathematical model of metacarpal subchondral bone adaptation, microdamage, and repair in racehorses
Pan, M.; Malekipour, F.; Pivonka, P.; Morrice-West, A. V.; Flegg, J. A.; Whitton, C.; Hitchens, P. L.
10.1101/2025.04.06.646486 — animal behavior and cognition — Posted on 2025-04-07
4032 Green cities and the risk for vector-borne disease transmission for humans and animals: a scoping review
Mercat, M.; Bartholomee, C.; Fournet, F.; Alcover Amengual, M.; Bourquia, M.; Bouhsira, E.; Cornel, A.; Fernandez-Cassi, X.; Fontenille, D.; Ibanez-Justicia, A.; Marti, R.; Moiroux, N.; Niang, E. H.; Smith, W.; Spitzen, J.; Visser, T.; Koenraadt, C. J. M.; Simard, F.
10.1101/2025.04.01.646559 — ecology — Posted on 2025-04-07
4034 Genetic compensation in podocalyxin-like mutants during zebrafish liver development
Ross, A. N.; Miscik, N. M.; Kalasekar, S. M.; Harris, J. D.; Tran, M.; Saxena, A.; Baker, S. A.; Evason, K. J.
10.1101/2025.04.07.647300 — developmental biology — Posted on 2025-04-07
4036 The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the C. elegans intestine
Torzone, S. K.; Carroll, T.; Breen, P. C.; Cohen, N. R.; Simmons, K. N.; VanDerMolen, K. R.; Nehrke, K. W.; Dowen, R. H.
10.1101/2024.05.06.592787 — cell biology — Posted on 2025-04-07
4037 Transitions in dynamical regime and neural mode underlie perceptual decision-making
Luo, T. Z.; Kim, T. D.; Gupta, D.; Bondy, A. G.; Kopec, C. D.; Elliott, V. A.; DePasquale, B.; Brody, C.
10.1101/2023.10.15.562427 — neuroscience — Posted on 2025-04-07
4038 The brain dynamics of congenitally blind people seeing faces and letters via sound
Matusz, P. J. J.; Reich, L.; Stolz, L. A.; Retsa, C.; Tovar, D. A.; Striem-Amit, E. R.; Aggius-Vella, E.; Amedi, A.; Murray, M. M.
10.1101/2025.01.22.634358 — neuroscience — Posted on 2025-04-07
4039 Scalp EEG predicts intracranial brain activity in humans
Subramanian, A. K.; Talbot, A.; Kim, N.; Parmigiani, S.; Cline, C. C.; Solomon, E. A.; Hartford, J. W.; Huang, Y.; Mikulan, E.; Zauli, F. M.; d'Orio, P.; Cardinale, F.; Mannini, F.; Pigorini, A.; Keller, C.
10.1101/2025.04.07.647612 — neuroscience — Posted on 2025-04-07
4041 Sulfotransferase 4A1 (SULT4a1): A Novel Neuroprotective Protein in Stroke
Hossain, M. I.; Khan, J.; Lee, J. H.; Falany, C. N.; King, P. H.; Bolding, M.; Andrabi, S. A.
10.1101/2025.04.07.647574 — neuroscience — Posted on 2025-04-07
4042 Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning
Li, H.; Zhuo, C.; Cui, Z.; Cieslak, M.; Salo, T.; Gur, R. E.; Gur, R. C.; Shinohara, R. T.; Oathes, D. J.; Davatzikos, C.; Satterthwaite, T. D.; Fan, Y.
10.1101/2025.04.07.647618 — neuroscience — Posted on 2025-04-07
4043 Unreal? A Behavioral, Physiological, and Computational Model of the Sense of Reality
Drori, G.; Bar-Tal, P.; Hirsh, O.; Berlinger, A.; Goldberg, N.; Zvilichovsky, Y.; Hertz, U.; Zaidel, A.; Salomon, R.
10.1101/2025.04.07.647542 — neuroscience — Posted on 2025-04-07
4044 Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter loss in concussive head injury
D'Mello, V. d.; Mihailovic, J.; Ali, S.; Sanganahalli, B. G.; Coman, D.; Hyder, F.; Fernando, M.; Mampilly, A.; Kannurpatti, S. S.; Levison, S. W.
10.1101/2025.04.07.647435 — neuroscience — Posted on 2025-04-07
4045 Flower/1 FLWR-1 regulates neuronal activity via the plasma membrane Ca2+-ATPase to promote recycling of synaptic vesicles
Seidenthal, M.; Redzovic, J.; Liewald, J. F.; Rentsch, D.; Shapiguzov, S.; Schuh, N.; Rosenkranz, N.; Eimer, S.; Gottschalk, A.
10.1101/2024.10.07.617020 — neuroscience — Posted on 2025-04-07
4047 High-throughput histopathology for complex in vitro models
Harter, M. F.; D'Arcangelo, E.; Aubert, J.; Lavickova, B.; Havnar, C.; Stoll, B.; Cubela, I.; Filip, A. M.; Gaspa-Toneu, L.; Scherer, J.; Karagkiozi, E.; Dupre, J.-S.; Lopez-Sandoval, R.; Hsia, R.; Norona, L.; Brancati, G.; Okuda, R.; Camp, G.; Shamir, E.; Garcia-Cordero, J. L.; Pereiro, I.; Gjorevski, N.
10.1101/2025.04.01.646522 — pathology — Posted on 2025-04-07
4049 Benchmarking of spatial transcriptomics platforms across six cancer types
Cervilla, S.; Grases, D.; Perez, E.; Musulen, E.; Real, F. X.; Aprea-Perez, J.; Esteller, M.; Porta-Pardo, E.
10.1101/2024.05.21.593407 — genomics — Posted on 2025-04-07
4050 How drought and ploidy level shape gene expression and DNA methylation in Phragmites australis
Kuprina, K.; Haldan, K.; Saenko, S.; Gulam, M. S.; Kreyling, J.; Schnittler, M.; Bog, M.
10.1101/2025.03.31.646440 — ecology — Posted on 2025-04-07
4058 Immune phenotype-guided identification of disease-associated pathobionts in Crohn's disease
Nagao-Kitamoto, H.; Sugihara, K.; Kitamoto, S.; Ebihara, S.; Kim, Y.; Newman, K. L.; Alonso, U.; Suzuki, T.; Kioi, Y.; Yunesi, A.; Inohara, N.; Alteri, C. J.; Minar, P.; Denson, L. A.; Higgins, P.; Kao, J. Y.; Bishu, S.; Xie, Y.; Lei, Y. L.; Kamada, N.
10.1101/2025.04.01.646605 — immunology — Posted on 2025-04-07
4059 Tick-borne coinfections modulate CD8+ T cell response and progressive leishmaniosis
Scorza, B. M.; Pessoa-Pereira, D.; Pabon-Rodriguez, F.; Beasley, E. A.; Mahachi, K.; Cox, A. D.; Kontowicz, E.; Baccam, T.; Wilson, G.; Waugh, M. C.; Vollmer, S.; Toepp, A.; Raju, K.; Chigbo, O.; Elliff, J.; Becker, G.; Cyndari, K. I.; Tang, S.; Brown, G.; Petersen, C. A.
10.1101/2025.04.03.647089 — immunology — Posted on 2025-04-07
4061 Plasmidome-defensome interactions drive adaptation of 'Fervidacidithiobacillus caldus' in natural and industrial extreme acidic environments
Quatrini, R.; Pacheco-Acosta, S.; Castro-Toro, G.; Rojas-Villalobos, C.; Valenzuela, C.; Haristoy, J. J.; Zapata-Araya, A.; Moya-Beltran, A.; Sepulveda-Rebolledo, P.; Perez-Rueda, E.; Ulloa, R.; Giaveno, A.; Issotta, F.; Diez, B.; Beard, S.
10.1101/2025.04.02.646953 — genomics — Posted on 2025-04-07
4063 Using CRISPR barcoding as a molecular clock to capture dynamic processes at single-cell resolution
Andres-Lopez, Y.; Santambrogio, A.; Kafetzopoulos, I.; Todd, C.; Alda-Catalinas, C.; Clark, S. J.; Reik, W.; Hernando-Herraez, I.
10.1101/2024.10.14.618192 — cell biology — Posted on 2025-04-07
4067 Fleming: An AI Agent for Antibiotic Discovery in Mycobacterium Tuberculosis
Wei, Z.; Ektefaie, Y.; Zhou, A.; Negatu, D.; Aldridge, B. B.; Dick, T. B.; Skarlinski, M.; White, A.; Rodriques, S. G.; Hosseiniporgham, S.; Inna, K. V.; Sacchettini, J.; Zitnik, M.; Farhat, M. R.
10.1101/2025.04.01.646719 — bioinformatics — Posted on 2025-04-07
4070 Mother-child dyadic interactions shape children's social brain and theory of mind
Li, L.; Xiao, J.; Zhao, W.; Zheng, Q.; Huang, X.; Shan, X.; Ming, Y.; Wang, P.; Wu, Z.; Chen, H.; Menon, V.; Duan, X.
10.1101/2024.09.23.614623 — neuroscience — Posted on 2025-04-07
4071 Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity
Karagulyan, N.; Überegger, M.; Qi, Y.; Babai, N.; Hofer, F.; Johnson Chacko, L.; Wang, F.; Luque, M.; Glueckert, R.; Schrott-Fischer, A.; Hua, Y.; Moser, T.; Bandtlow, C.
10.1101/2024.09.16.613011 — neuroscience — Posted on 2025-04-07
4076 Visualizing nuclear pore complex plasticity with pan-Expansion Microscopy
Morgan, K. J.; Carley, E.; Coyne, A. N.; Rothstein, J. D.; Lusk, C. P.; King, M. C.
10.1101/2024.09.18.613744 — cell biology — Posted on 2025-04-07
4077 Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease
Fontana, L.; Martinucci, P.; Amistadi, S.; FELIX, T.; MOMBLE, M.; TACHTSIDI, A.; CORRE, G.; Chalumeau, A.; Hardouin, G.; Martin, J.; Romano, O.; amendola, m.; Antoniou, P.; Miccio, A.
10.1101/2024.12.13.628398 — molecular biology — Posted on 2025-04-07
4078 Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity
Kulakova, L.; Li, K. H.; Chiang, A. W. T.; Schwoerer, M. P.; Schoffelen, S.; Elkholy, K.; Chao, K. L.; Shahid, S.; Kumar, B.; Murray, N. B.; Archer-Hartmann, S.; Azadi, P.; Voldborg, B. G.; Marin, A.; Mariuzza, R. A.; Andrianov, A. K.; Ploss, A.; Lewis, N. E.; Toth, E. A.; Fuerst, T. R.
10.1101/2025.04.02.646860 — immunology — Posted on 2025-04-07
4081 Conserved energetic changes drive function in an ancient protein fold
Wells, M. L.; Lu, C.; Sultanov, D.; Weber, K. C.; Gong, Z.; Glasgow, A.
10.1101/2025.04.02.646877 — biophysics — Posted on 2025-04-07
4085 High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy
Guan, H.; Chen, J.; Kaur, K.; Amreen, B.; Lesseur, C.; Dolios, G.; Andra, S.; Narasimhan, S.; Pulivarthi, D.; Midya, V.; De Witte, L. D.; Bergink, V.; Rommel, A. S.; Petrick, L.
10.1101/2024.12.16.628663 — bioinformatics — Posted on 2025-04-07
4088 Global characterization of Dictyostelium discoideum gene expression changes under hypoxic conditions
Hesnard, J.; Gas-Pascual, E.; van der Wel, H.; Cochet-Escartin, O.; Joly, S.; Rieu, J.-P.; West, C. M.; Anjard, C.
10.1101/2025.04.02.646759 — genomics — Posted on 2025-04-07
4089 PERADIGM: Phenotype Embedding Similarity-based Rare Disease Gene Mapping
Zheng, W.; Xie, Y.; Gu, J.; Li, H.; Somlo, S.; Besse, W.; Zhao, H.
10.1101/2025.04.01.646670 — genetics — Posted on 2025-04-07
4090 Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx
Larsen, R.; Kucharz, K.; Aydin, S.; Micael, M. K. B.; Choudhury, B.; Paulchakrabarti, M.; Lonstrup, M.; Lin, D. C.; Abeln, M.; Muenster-Kuhnel, A.; Gomez Toledo, A.; Lauritzen, M.; Esko, J. D.; Daneman, R.
10.1101/2025.04.07.645297 — molecular biology — Posted on 2025-04-07
4091 Reproducible generation of Nipah virus pseudovirions with uniform expression of F and G surface glycoproteins for high-throughput neutralization assays
Varghese, G. R.; Vijay, V.; Sreedevi, S.; Lupitha, S. S.; Prabhakaran, P.; Aswathyraj, S.; Moorkoth, A. P.; Pulloor, N. K.; Sreekumar, E.
10.1101/2025.04.07.647518 — microbiology — Posted on 2025-04-07
4092 Predicting specificity of TCR-pMHC interactions using machine learning and biophysical models
Culka, M.; Lounsbury, N. W.; Thrift, W.; Nerli, S.; Wallace, A.; Nikolenyi, G.; Orlova, D.; Mukhyala, K.; AlQuraishi, M.
10.1101/2025.04.04.647165 — immunology — Posted on 2025-04-07
4093 Volume conductor models for magnetospinography
O'Neill, G. C.; Spedden, M. E.; Schmidt, M.; Mellor, S.; Stenroos, M.; Barnes, G. R.
10.1101/2024.11.04.621905 — neuroscience — Posted on 2025-04-07
4094 Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.
Douros, J. D.; Capozzi, M.; Novikoff, A.; Mokrosinski, J.; DuBois, B.; Stock, J.; Rohlfs, R.; Anderson, M.; Jedrzejcyk, D. J.; Poulsen, S.; Blenke, E. O.; Dago, T.; Huus, K.; Kobberup, S.; Rivir, M.; Sorrell, J.; Mowery, S.; Drucker, D. J.; D'Alessio, D. A.; Campbell, J. E.; Muller, T. D.; Perez-Tilve, D.; Knerr, P. J.; Finan, B.
10.1101/2025.04.01.646483 — zoology — Posted on 2025-04-07
4098 Chemical Compensation to Mechanical Loss in CellMechanosensation
Ni, Q.; Ge, Z.; Sen, A.; Wu, Y.; Fu, J.; Amitrano, A.; Srivastava, N.; Konstantopoulos, K.; Sun, S.
10.1101/2025.04.02.646640 — biophysics — Posted on 2025-04-07
4104 Targeting the ITGA3B1 Complex with A Novel Antibody-Drug Conjugate for Metastatic Bladder Cancer
Jung, H.; Lee, J.; Kim, E. G.; Ahn, J.; Haffner, M.; Nelson, P. S.; Kim, K.; Lee, J. K.; Yi, E. C.; Kim, K. M.
10.1101/2025.04.06.647354 — synthetic biology — Posted on 2025-04-07
4105 A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
Sternisha, A. C.; Li, H.; Traylor, J. I.; Guo, L.; Jun, J. H.; Zhao, X.; Gajendra, K.; Ouyang, Q.; Schmidt, M.; Fleishman, M.; Shi, D. D.; Savani, M. R.; Xiao, Y.; Lee, J. H.; Zacharias, L. G.; Mathews, T. P.; Gordillo, R.; Kim, Y. J.; Xu, L.; Doench, J. G.; Koduri, V.; Abdullah, K. G.; Banaszynski, L. A.; Agathocleous, M.; DeBerardinis, R. J.; Morrow, E. M.; McBrayer, S. K.
10.1101/2025.04.06.647450 — synthetic biology — Posted on 2025-04-07
4106 Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain
Bonnifet, T.; Sinnassamy, S.; Massiani-Beaudoin, O.; Mailly, P.; Monnet, H.; Loew, D.; Lombard, B.; Servant, N.; Joshi, R. L.; Fuchs, J.
10.1101/2023.12.12.571308 — neuroscience — Posted on 2025-04-07
4107 Fast and memory efficient searching of large-scale mass spectrometry data using Tide
Kertesz-Farkas, A.; Acquaye, F. L. N. A.; Ostapenko, V.; Locon, R. H.; Lu, Y.; Grant, C. E.; Noble, W. S.
10.1101/2025.04.01.646675 — bioinformatics — Posted on 2025-04-07
4108 Surface Wetting Is a Key Determinant of α-Synuclein Condensate Maturation
Thrush, R. J.; Vadukul, D. M.; Allerton, S. C.; Storch, M.; Aprile, F. A.
10.1101/2024.06.06.597302 — biochemistry — Posted on 2025-04-07
4110 The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data
Zhang, S.; Chen, X.; Jin, E.; Wang, A.; Chen, T.; Zhang, X.; Zhu, J.; Dong, L.; Sun, Y.; Yu, C.; Zhou, Y.; Fan, Z.; Chen, H.; Zhai, S.; Sun, Y.; Chen, Q.; Xiao, J.; Song, S.; Zhang, Z.; Bao, Y.; Wang, Y.; Zhao, W.
10.1101/2025.03.31.646270 — genomics — Posted on 2025-04-07
4111 ALGR: A multi-purpose agricultural landscape generator in R
Goldstein, E.; Deutscher, A.; O'Keeffe, E.; Wiegand, K.
10.1101/2025.03.31.646291 — ecology — Posted on 2025-04-07
4112 Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
Skamagki, M.; Zhang, C.; Hacisuleyman, E.; Galleti, G.; Wu, C.; Vinagolu, R. K.; Cha, H.; Ata, D.; Kim, J.; Weiskittel, T.; Diop, M.; Aung, T.; Del Latto, M.; Kim, A. S.; Li, Z.; Miele, M.; Zhao, R.; Tang, L. H.; Hendrickson, R. C.; Romesser, P. B.; Smith, J. J.; Giannakakou, P.; Darnell, R. B.; Bott, M. J.; Li, H.; Kim, K.
10.1101/2025.04.04.647279 — cell biology — Posted on 2025-04-07
4113 Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity
Duarte-Ruiz, M.; Moreno-Castillo, A.; El Yousfi, Y.; Moreno-Castro, C.; Martinez-Martinez, N.; Jimenez-Lozano, S.; Kennel, M.; Ruiz-Rodriguez, C.; Rodriguez-Caparros, A.; Lopez-Ros, J.; de la Grange, P.; Hernandez-Munain, C.; Sune, C.
10.1101/2025.04.07.647526 — cell biology — Posted on 2025-04-07
4115 Tn-seq of Thermus thermophilus genome reveals unexpected tolerance to insertions in bacterial common essential genes.
Gomez-Campo, C. L.; Gost, M.; Sousa de Silva, B. F.; Alvarez, L.; Berenguer, J.; Redrejo-Rodriguez, M.; Mencia, M.
10.1101/2025.04.03.647156 — microbiology — Posted on 2025-04-07
4116 HPV16 neutralizing monoclonal antibodies show evidence for common developmental pathways and public epitopes
Carter, J. J.; Hurlburt, N. K.; Scherer, E. M.; Singh, S.; Rodarte, J. V.; Smith, R. A.; Lewis, P.; Kinzelman, R. J.; Kieltyka, J.; Caban, M. E.; Wipf, G. C.; Pancera, M.; Galloway, D. A.
10.1101/2025.03.31.646278 — immunology — Posted on 2025-04-07
4122 Distinct cerebrospinal fluid DNA methylation signatures linked to Alzheimer's disease
Rados, M.; Klotz, S.; Regelsberger, G.; Stögmann, E.; Landegger, L. D.; Fetahu, I. S.
10.1101/2025.04.03.647115 — neuroscience — Posted on 2025-04-07
4123 Hepatic Yap1 activates systemic catabolism and muscle loss during organ repair: evidence for a liver-derived common mechanism with cancer cachexia.
HAMIDI, T.; Yang, Y.; Robinson, T. P.; Kronbergs, A.; Au, E.; Rupert, J. E.; Zhong, X.; Lal, S.; Liang, T.; Robling, A. G.; Hoggatt, A.; Carvalho, R.; Cury, S. S.; Wells, C.; Zimmers, T.; Koniaris, L. G.
10.1101/2025.04.01.646698 — physiology — Posted on 2025-04-07
4124 Real-time imaging of rotation during synthesis by the replisome
Retzer, T. M.; Rajappa, L. T.; Takahashi, M.; Hamdan, S. M.; Duderstadt, K. E.
10.1101/2025.04.01.646591 — biophysics — Posted on 2025-04-07
4126 SAUNA - Simulated Annealing for Unique Nucleosome Arrangements from Cell-Free DNA-Sequencing Data
Lambrinos, M. R.; Rahimi, T.; Mehra, T.; Schmid, M. P.; Miglino, N.; Romanens, A.; Mertz, K. D.; Krauthammer, M.; Nienhold, R.; Wicki, A.; Balazs, Z.
10.1101/2025.04.01.646532 — bioinformatics — Posted on 2025-04-07
4127 Big Bones Mean Big Muscles: AI Quantifies 71 Individual Muscles Across the Whole Body, Revealing Widespread Links Between Muscle, Bone, and Body Size
Riem, L.; Pinette, M.; DuCharme, O.; Pabon, V.; Coggins, A.; Harold, L.; Costanzo, K. E.; Cousins, M.; Hein, R.; Rhodes, M.; Llevens, E.; Feng, X.; Benusa, S.; Breeding, T.; Derave, W.; Blemker, S. S.
10.1101/2025.04.01.646599 — bioengineering — Posted on 2025-04-07
4128 Insulin exerts epigenetic control of joint-specific memory T cells in rheumatoid arthritis
Chandrasekaran, V.; Erlandsson, M. C.; Svensson, D.; Malmhall-Bah, E.; Silfversward, S. T.; Katona, G.; Pullerits, R.; Bokarewa, M. I.
10.1101/2025.04.01.646580 — immunology — Posted on 2025-04-07
4129 Deep Learning-Driven Subtype Classification of Colorectal Cancer Using Histopathology Images for Personalized Medicine
Truong Le, T.; Nguyen-Truong, V.-T.; Trong Le Phan, N.; Duong Van Nhat, Q.; Fortune Mavuso, M.; Nguyen Thien Dao, P.; Ngoc Anh Nguyen, H.; Thuy Mai, T.; Thi Quang, K.
10.1101/2024.12.12.628270 — cancer biology — Posted on 2025-04-07
4131 Stage-specific CAR-mediated signaling generates naive-like, TCR-null CAR T cells from induced pluripotent stem cells
Yoo, S. P.; Yuan, X.; Engstrom, C.; Chang, P. C.; Li, S.; Lathrop, L. E.; Lagosh, J. A.; Saripalli, S.; Azzun, A.; Calvanese, V.; Mikkola, H.; Seet, C. S.; Kohn, D. B.; Crooks, G. M.
10.1101/2024.11.25.624041 — bioengineering — Posted on 2025-04-07
4132 Molecular basis for multidrug efflux by an anaerobic RND transporter
Lawrence, R.; Athar, M.; Uddin, M. R.; Adams, C.; Sousa, J.; Durrant, O.; Lellman, S.; Sutton, L.; Keevil, C. W.; Patel, N.; Prosser, C.; McMillan, D.; Zgurskaya, H. I.; Vargiu, A. V.; Ahdash, Z.; Reading, E.
10.1101/2025.04.04.646765 — biochemistry — Posted on 2025-04-07
4134 Neural and Behavioral Changes in Older Adults from Auditory-Cognitive Training
Fisher, C.; Karunathilake, I. M. D.; Johns, M. A.; Vance, A.; Kuchinsky, S. E.; Anderson, S.; Simon, J. Z.
10.1101/2025.04.01.646593 — neuroscience — Posted on 2025-04-07
4135 Distorting anatomy to test MEG models and metrics
Lopez, J. D.; Balbastre, Y.; Ashburner, J.; Bonaiuto, J.; Barnes, G.
10.1101/2025.04.03.646622 — neuroscience — Posted on 2025-04-07
4137 Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
Iannitelli, A. F.; Hassanein, L.; Tish, M. M.; Mulvey, B.; Blankenship, H.; Korukonda, A.; Liles, L. C.; Sharpe, A. L.; Pare, J.-F.; Villalba, R.; Segal, A.; Sloan, S. A.; Martinowich, K.; Dougherty, J. D.; McCann, K. E.; Smith, Y.; Beckstead, M. J.; Weinshenker, D.
10.1101/2023.03.07.530845 — neuroscience — Posted on 2025-04-07
4138 Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma
Dhall, A.; Taniyama, D.; Elloumi, F.; Luna, A.; Varma, S.; Kumar, S.; Escobedo, L.; Aladjem, M. I.; Redon, C. E.; Roper, N. I.; Reinhold, W. C.; Rivero, J. D.; Pommier, Y.
10.1101/2025.04.03.647086 — cancer biology — Posted on 2025-04-07
4139 Imputation Disparities Driven by Recent Selectionand Their Impact on Disease Risk Estimation in East and Southeast Asian Populations
Li, D.; Tangtanatakul, P.; Lei, Y.; Liu, X.; Huang, H.-Y.; Lin, Y.-C.-D.; Li, C.; Chen, Y.; Cai, L.; Zhao, J.; Pisitkul, P.; Suangtamai, T.; Yu, J.; Zhou, Y.; Kunhapan, P.; Sun, R.; Yu, G.; Sun, H.; Hirankarn, N.; Huang, H.-D.; Yang, W.; Wang, Y.-F.
10.1101/2025.04.03.646928 — genomics — Posted on 2025-04-07
4140 Revisiting the African mtDNA Landscape: A Continental Update from Complete Mitochondrial Genomes
Lankheet, I.; Chowdhury, A.; Tellgren-Roth, C.; Jolly, C.; Soares, A. E. R.; de Navascues, M.; Pacchiarotti, S.; Maselli, L.; Kouarata, G.; Donzo, J.-P.; Coetzee, V.; de Castro, M.; Ebbesen, P.; Priehodova, E.; Podgorna, E.; Cerny, V.; Green, S. T.; Harena, P.; Bakrobena, L.; Fomine, F. L. M.; Tolesa, Z. G.; Mengesh, W. A.; de Jongh, M.; Soodyall, H.; Bostoen, K.; Barbieri, C.; Larena, M.; Malmstrom, H.; Schlebusch, C. M.
10.1101/2025.04.05.647361 — evolutionary biology — Posted on 2025-04-07
4142 Longitudinal multimodal neuroimaging after traumatic brain injury
Radanovic, A.; Jamison, K. W.; Kang, Y.; Shah, S.; Kuceyeski, A.
10.1101/2025.04.04.647315 — neuroscience — Posted on 2025-04-07
4146 Alectinib enhances response to RBM39 degradation via SRPK1 inhibition
Ma, Y.; Poon, E.; Jin, C.; Martins da Costa, B.; Xu, Y.; Quazi, S.; Zourdoumis, N.; Wickremesinghe, C.; Chesler, L.; Keun, H. C.; Nijhuis, A.
10.1101/2025.03.28.644532 — cancer biology — Posted on 2025-04-07
4147 AQuaRef: Machine learning accelerated quantum refinement of protein structures
Zubatyuk, R.; Biczysko, M.; Ranasinghe, K.; Moriarty, N. W.; Gokcan, H.; Kruse, H.; Poon, B. K.; Adams, P. D.; Waller, M. P.; Roitberg, A. E.; Isayev, O.; Afonine, P. V.
10.1101/2024.07.21.604493 — biochemistry — Posted on 2025-04-07
4149 Habitat use differences mediate population threat exposure in white sturgeon
Walter, J. A.; Singer, G. P.; Reuman, D. C.; Colborne, S. F.; Sheppard, L. W.; O'Donnell, D. R.; Coombs, N.; Tracy, E.; Johnston, M.; Miller, E. A.; Steel, A. E.; Kelly, J. T.; Fangue, N. A.; Rypel, A. L.
10.1101/2022.08.31.505999 — ecology — Posted on 2025-04-07
4151 The Drosophila SPECC1L homolog, Split Discs, co-localizes with non-muscle myosin II and regulates focal adhesion dynamics.
Teran, A.; Jung, J.; Plantenkamp, A.; Pardini, A.; Zhao, A.; Chandramouli, S.; Jefferis, A.; Applewhite, D. A.
10.1101/2025.04.06.647460 — cell biology — Posted on 2025-04-06
4153 Learning the cellular origins of cancer using single-cell chromatin landscapes
Bairakdar, M. D.; Giotti, B.; Lee, W.; Stancl, P.; Wagenblast, E.; Hambardzumyan, D.; Polak, P.; Karlic, R.; Tsankov, A.
10.1101/2025.04.06.646131 — cancer biology — Posted on 2025-04-06
4154 Super-Resolution Diffusivity Mapping Reveals Spatial Correlations Between Lateral Mobility and Structural Heterogeneities on Cellular Membranes
Han, C.; Zhao, Z.; Gao, H.; Deng, J.; Wang, Q.; Wang, Y.; Liu, L.; Xu, L.; Jiang, S.; Zhan, X.; Chen, K.; Yan, R.; Li, W.; Huang, W.; Xu, K.; Xiang, L.
10.1101/2025.04.01.646704 — biophysics — Posted on 2025-04-06
4158 The functional organization of chromosome territories in single nuclei during zygotic genome activation
Shankar Ganesh, A.; Orban, T. M.; Raj, R.; Fatzinger, P. I.; Johnson, A.; Riccard, S. M.; Zhanaidarov, A.; Inaba, M.; Erceg, J.
10.1101/2025.04.06.647428 — developmental biology — Posted on 2025-04-06
4159 β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function
Anderson, P.; Xiao, P.; Zhong, Y.; Kaakati, A.; Alfonso-DeSouza, J.; Zhang, T.; Zhang, C.; Qi, L.; Ding, W.; Liu, S.; Pani, B.; Krishnan, A.; Chen, O.; Jassal, C.; Strawn, J.; Sun, J.; Rajagopal, S.
10.1101/2025.04.05.647240 — cell biology — Posted on 2025-04-06
4161 Prevalence of Campylobacter and non-typhoidal Salmonella along broiler chicken production and distribution networks, Vietnam
Xin, C.; Thi, T. H.; Duong, T. Q.; Nhat, T. T.; Pham, H. T. T.; Son, D. T. T.; Huong, L. Q.; Nhung, L. T. H.; Butt, S.; Hang, T. T. T.; Seow, K.; Hennessey, M.; Lehri, B.; Lam, C. T. A.; Gerber, P. F.; Conway, P. L.; Stabler, R. A.; Blake, D.; Tomley, F.; Pfeiffer, D.; Thi, N. P.; Fournie, G.; Conan, A.
10.1101/2025.04.03.647142 — microbiology — Posted on 2025-04-06
4162 Lack of Bcl6 promotes anti-tumor immunity by activating glycolysis to rescue CD8 T cell function
Nemazee, D.; Luan, F.; Li, Y.; Ning, J.; Tran, J. T.; Blane, T.; Bhargava, R.; Huang, Z.; Xiao, C.
10.1101/2025.04.01.646721 — immunology — Posted on 2025-04-06
4164 Environmental dependence of colony morphologies in Labyrinthula species
Knight, J. M.; Gonzalez, P.; Fairhurst, D. J.; Melaugh, G.; Poon, W. C. K.
10.1101/2025.04.01.646626 — biophysics — Posted on 2025-04-06
4165 Bacterial motility patterns vary smoothly with spatial confinement and disorder
Zhang, H.; Wetherington, M. T.; Ko, H.; FitzGerald, C. E.; Luzzatto, L. V.; Kovacs, I. A.; Munro, E. M.; Nirody, J. A.
10.1101/2024.09.29.615714 — biophysics — Posted on 2025-04-06
4169 Optical Phenotyping Using Label-Free Microscopy and Deep Learning
Guan, S.; Knapp, T.; Duan, S.; Alfonso Garcia, A.; Sawyer, T. W.
10.1101/2025.04.01.646480 — bioengineering — Posted on 2025-04-06
4171 Ecology and demographic structure of an extinct ibex population in Upper Palaeolithic Italian Alps
Armaroli, E.; Fontani, F.; Iacovera, R.; Cilli, E.; Latorre, A.; Luiselli, D.; Silvestrini, S.; Terlato, G.; Dalmeri, G.; Fontana, A.; Nannini, N.; Vonhof, H.; Calcagnile, L.; Quarta, G.; Duches, R.; Bortolini, E.; Cipriani, A.; Benazzi, S.; Lugli, F.; Romandini, M.
10.1101/2025.04.01.646553 — ecology — Posted on 2025-04-06
4174 Lysophosphatidic acid controls autotaxin binding to 1-integrin: impact on disease progression in murine collagen-induced arthritis.
Emery, M.; Cuero, C. N.; Bouazza, L.; Internicola, C.; Duboeuf, F.; Cerecero-Aguirre, P.; McCarthy, A. A.; Machuca-Gayet, I.; Leblanc, R.; Peyruchaud, O.
10.1101/2025.04.04.646839 — cell biology — Posted on 2025-04-06
4176 Protein Secondary Structure Patterns In Short-Range Cross-Link Atlas
Vetrano, A.; Di Ianni, A.; Di Fonte, N.; Dell'Orletta, G.; Reale, S.; Daidone, I.; Iacobucci, C.
10.1101/2025.04.03.647081 — molecular biology — Posted on 2025-04-06
4179 Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity
Wassarman, D. R.; Pfaff, P.; Paulo, J. A.; Gygi, S. P.; Shokat, K. M.; Kranzusch, P. J.
10.1101/2025.04.06.647259 — microbiology — Posted on 2025-04-06
4180 REPOP: bacterial population quantification from platecounts
Pessoa, P.; Lu, C.; Tashev, S. A.; Kruithoff, R.; Shepherd, D. P.; Presse, S.
10.1101/2025.04.01.644179 — microbiology — Posted on 2025-04-06
4181 Microbial single-cell omics in situ
Lan, X.; Liang, Q.; He, J.; Wu, J.; Zhang, X.; Li, F.; Zhao, G.-P.; Guo, R.; Li, L.; Jia, H.
10.1101/2024.07.07.602369 — microbiology — Posted on 2025-04-06
4183 Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases
Chakraborty, A.; Mitra, J.; Malojirao, V. H.; Kodavati, M.; Mandal, S. M.; Gill, S. K.; Sreenivasmurthy, S. G.; Vasquez, V.; Mankevich, M.; Krishnan, B.; Ghosh, G.; Hegde, M.; Hazra, T.
10.1101/2024.11.13.623464 — neuroscience — Posted on 2025-04-06
4185 Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka
Nishiike, Y.; Maki, S.; Miyazoe, D.; Nakasone, K.; Kamei, Y.; Todo, T.; Ishikawa-Fujiwara, T.; Ohno, K.; Usami, T.; Nagahama, Y.; Okubo, K.
10.1101/2024.02.13.580203 — neuroscience — Posted on 2025-04-06
4187 In vivo cell-type and brain region classification via multimodal contrastive learning
Yu, H.; Lyu, H.; Xu, E. Y.; Windolf, C.; Lee, E. K.; Yang, F.; Shelton, A. M.; Olsen, S.; Minavi, S.; Winter, O.; The International Brain Laboratory, ; Dyer, E. L.; Chandrasekaran, C.; Steinmetz, N. A.; Paninski, L.; Hurwitz, C.
10.1101/2024.11.05.622159 — neuroscience — Posted on 2025-04-06
4189 Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations
Zeng, Q.; Patel, S.; Wang, X.; Hsieh, M.-H.; Li, Z.; Ren, X.; Wang, J.; Kim, D.; Li, S.; Gu, X.; Mannino, G.; Maggiore, G.; Fang, X.; Li, L.; Zhu, M.; Wang, M.; Li, B.; Bellary, A.; Lim, K.; Qi, Z.; Pushpa, P.; Mandour, M. O.; Saudek, V.; Sharma, T.; Zhang, Y.; Hoxhaj, G.; Mishra, P.; Gopal, P.; Campbell, P.; Hoare, M.; Savage, D.; Zhu, H.
10.1101/2025.04.01.646492 — physiology — Posted on 2025-04-06
4191 Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS)
Simar, S. R.; Tran, T. T.; Rydell, K. B.; Atterstrom, R. L.; Sahasrabhojane, P. V.; Dinh, A. Q.; Schettino, M. G.; Slanis, H. S.; Deyanov, A. E.; DeTranaltes, A. M.; Axell-House, D. B.; Miller, W. R.; Munita, J. M.; Tobys, D.; Seifert, H.; Biehl, L.; Zervos, M.; Suleyman, G.; Kaur, J.; Warzocha, V.; Cifuentes, R. O.; Abbo, L. M.; Shimose, L.; Liu, C.; Nguyen, K.; Miller, A.; Shelburne, S. A.; Arias, C. A.; Hanson, B. M.
10.1101/2025.04.01.645485 — genomics — Posted on 2025-04-06
4194 An update to the global Critical Habitat layer
Dunnett, S.; Muge, A.; Ross, A.; Turner, J. A.; Burgess, N. D.; Jones, M. I.; Brooks, S.
10.1101/2025.04.01.646588 — ecology — Posted on 2025-04-06
4196 DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication
Fernandez, A.; Zhou, T.; Esworthy, S.; Shen, C.; Liu, H.; Hess, J. D.; Yuan, H.; Liu, N.; Shi, G.; Zhou, M.; Kosiyatrakul, S. T.; Gaur, V.; Sommers, J.; Edelman, W.; Li, G.-M.; Brosh, R.; Chai, W.; Lee, M. Y. W. T.; Zhang, D.; Zheng, L.; Shen, B.
10.1101/2025.04.04.647332 — molecular biology — Posted on 2025-04-06
4197 Therapeutic Potential of 20E in Pulmonary Arterial Hypertension: Involvement of Mas Receptor and PI3K/Akt Pathway
Lu, T.; Jia, W.; Wang, Y.; Ma, Y.; Du, F.; Gao, H.; Song, C.; Li, H.; Jin, X.; Liu, C.; Jin, H.; Lin, Y.
10.1101/2025.04.03.647130 — molecular biology — Posted on 2025-04-06
4198 TEAD1 is a novel regulator of NRF2 and oxidative stress response in cardiomyocytes
Jagannathan, R.; Lee, J.; De Vallance, E.; Negi, V.; Mandi, V.; Vyas, H.; Li, F.; Pagano, P. J.; Yechoor, V.; Moulik, M.
10.1101/2025.04.06.647438 — molecular biology — Posted on 2025-04-06
4199 Target-induced Argonaute-HNH filaments confer bacterial immunity
Kanevskaya, A.; Lisitskaya, L.; Moiseenko, A. V.; Sokolova, O. S.; Sluchanko, N. N.; Kulbachiskiy, A.
10.1101/2025.04.06.647449 — molecular biology — Posted on 2025-04-06
4200 The type I and III interferon responses restrict infection with tick-borne orthoflaviviruses through IFI6
Streicher, F.; Kenney, D.; Caval, V.; Chazal, M.; Aicher, S.-M.; Gracias, S.; Roesch, F.; Douam, F.; Jouvenet, N.
10.1101/2025.04.06.647422 — microbiology — Posted on 2025-04-06
4202 Statistical Characterization of Cortical-Thalamic Dynamics Evoked by Cortical Stimulation in Mice
Nigrisoli, D.; Russo, S.; Freddi, R.; Seseri, N.; Corti, S.; Ottoboni, L.; Barbieri, R.
10.1101/2025.04.04.647222 — neuroscience — Posted on 2025-04-06
4206 Comparative analysis of mammalian adaptive immune loci revealed spectacular divergence and common genetic patterns
Pospelova, M.; Voss, K.; Zamyatin, A.; Watson, C. T.; Koepfli, K.-P.; Pennell, M.; Safonova, Y.
10.1101/2025.04.01.646651 — genomics — Posted on 2025-04-06
4208 The effect of G-quadruplexes on TDP43 condensation, distribution, and toxicity
Oldani, E. G.; Reynolds Caicedo, K. M.; Spaeth Herda, M. E.; Sachs, A. H.; Chapman, E. G.; Kumar, S.; Linseman, D. A.; Horowitz, S.
10.1101/2024.04.30.591873 — molecular biology — Posted on 2025-04-06
4209 Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson's disease
Alegre-Abarrategui, J.; Otero-Jimenez, M.; Wojewska, M. J.; Jogaudaite, S.; Miller, D.; Gray-Rodriguez, S.; Geoghegan, G. C.; Abelleira-Hervas, L.; Viney, T. J.; Sarkany, B.; Gveric, D.; Gentleman, S.
10.1101/2025.04.05.647370 — neuroscience — Posted on 2025-04-06
4214 A microbiome-derived transfer RNA modification underlies behavioral optimums and predator avoidance in mosquito larvae
Kelley, M.; Rathore, S.; Chandrasegaran, K.; Herbert, C.; Sabile, C. E. G.; Wood, T.; Joves, J.; Palacios, A.; Susanto, E.; Uhran, M.; Ramirez, A. L.; Chen, S.-C.; Singh, K.; Khalid, M. S.; Vinauger, C.; Buschbeck, E.; Limbach, P. A.; Benoit, J. B.
10.1101/2025.04.02.646203 — physiology — Posted on 2025-04-06
4217 Sex Chromosome Turnover and Structural Interspecific Genome Divergence Shapes Meiotic Outcomes in Hybridizing Cobitis
Schlebusch, S.; Trifonov, V.; Halenkova, Z.; Klianitskaya, M.; Dedukh, D.; Ruiz Herrera, A.; Alvarez Gonzalez, L.; Pujol Infantes, G.; Hribova, E.; Andjel, L.; Bartos, O.; Pajer, P.; Tichopad, T.; Kulik, D.; Kotusz, J.; Dolezalkova-Kastankova, M.; Bohne, A.; Marta, A.; Horna, P.; Reifova, R.; Guiguen, Y.; Paces, J.; Janko, K.
10.1101/2025.04.01.646337 — genomics — Posted on 2025-04-06
4218 Invasion blurs the biphasic mosaic, amplifies the 'wicked problem' through impacts on avian distributions in montane habitats.
Jobin, V.; Harikrishnan, C. P.; Lele, A.; Joshi, V.; Chanda, R.; Lawrence, S.; Aravind, P. S.; Mubeen, M.; Joseph, M. R.; Subash, M.; Nandini, R.; Das, A.; Jathanna, D.; Robin, V.
10.1101/2025.04.03.646526 — ecology — Posted on 2025-04-06
4220 XPC loss-of-function triggers melanomagenesis through CDKN2A downregulation
Chelakkot, V. S.; Thomas, K.; Romigh, T.; Bernat, A.; Samuel, R.; Goli, N.; Rambhia, P.; Ravichandran, S.; Wang, Q.-E.; Cooper, K.; Funchain, P.; Ni, Y.; Arbesman, J.
10.1101/2025.04.03.646637 — cancer biology — Posted on 2025-04-06
4221 Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas
Ruiz, C. F.; Ge, X.; McDonnell, R.; Agabiti, S. S.; McQuaid, D. C.; Tang, A.; Kharwa, M.; Goodell, J.; Saavedra-Pena, R. d. M.; Wing, A.; Li, G.; Pinto Medicine, N.; Robert, M. E.; Varshney, R. R.; Rudolph, M. C.; Gorelick, F. S.; Wysolmerski, J. J.; Canals, D.; Haley, J.; Rodeheffer, M. S.; Muzumdar, M. D.
10.1101/2025.04.04.645324 — cancer biology — Posted on 2025-04-06
4223 Scaling relations of multi-component phase coexistence boundaries
Qian, D.; Acker, J.; Scrutton, R.; Fischer, C. M.; Qamar, S.; Sneideris, T.; Borodavka, A.; Knowles, T.
10.1101/2025.04.02.645070 — biophysics — Posted on 2025-04-06
4224 SnoBIRD: A tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes
Fafard-Couture, E.; Boulanger, C.; Faucher-Giguere, L.; Sinagoga, V.; Berthoumieux, M.; Hedjam, J.; Marcel, V.; Durand, S.; Bayfield, M. A.; Bachand, F.; Elela, S. A.; Jacques, P.-E.; Scott, M. S.
10.1101/2025.04.01.646650 — bioinformatics — Posted on 2025-04-06
4227 Chromosome-level genome assembly of Tamarindus indica
Singh, M.; Bisht, M. S.; G, A. M.; Mahajan, S.; Sharma, V. K.
10.1101/2025.04.01.646601 — genomics — Posted on 2025-04-06
4229 Biological molybdenum usage stems back to 3.4 billion years ago
Klos, A.; Sobol, M.; Boden, J. S.; Stueeken, E. E.; Anderson, R. E.; Kurt O., K.; Kacar, B.
10.1101/2025.04.02.646658 — evolutionary biology — Posted on 2025-04-06
4232 CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2
Chang, C.-Y.; Hernandez-Armengol, R.; Paul, K.; Lee, J. Y.; Nance, K.; Shibata, T.; Yue, P.; Stehlik, C.; Gibb, D. R.
10.1101/2025.04.03.645598 — immunology — Posted on 2025-04-06
4234 SpatialAgent: An Autonomous AI Agent for Spatial Biology
Wang, H.; He, Y.; Coelho, P. P.; Bucci, M.; Nazir, A.; Chen, B.; Trinh, L.; Zhang, S.; Huang, K.; Chandrasekar, V.; Chung, D. C.; Hao, M.; Leote, A. C.; Lee, Y.; Li, B.; Liu, T.; Liu, J.; Lopez, R.; Tawaun, L.; Ma, M.; Makarov, N.; McGinnis, L.; Peng, L.; Ra, S.; Scalia, G.; Singh, A.; Tao, L.; Uehara, M.; Wang, C.; Wei, R.; Copping, R.; Rozenblatt-Rosen, O.; Leskovec, J.; Regev, A.
10.1101/2025.04.03.646459 — bioinformatics — Posted on 2025-04-06
4235 Implementation of an adaptive-optics assisted isoSTED nanoscope
Li, Y.; Lee, D.; Allgeyer, E. S.; Schroeder, L. K.; Tu, S.; Bewersdorf, J.; Hao, X.
10.1101/2025.04.02.645322 — bioengineering — Posted on 2025-04-06
4238 The transcription factor NO TRANSMITTING TRACT / WIP2 regulates cytokinin homeostasis in Arabidopsis
Diaz-Ramirez, D.; Demesa-Arevalo, E.; Duran-Medina, Y.; Becerra-Garcia, R. E.; Cruz-Valderrama, J. E.; Herrera-Ubaldo, H.; Chavez-Montes, R. A.; di Marzo, M.; Colombo, L.; Sagasser, M.; Simon, R.; Novak, O.; de Folter, S.; Marsch-Martinez, N.
10.1101/2025.04.03.645522 — plant biology — Posted on 2025-04-06
4240 Cell cycle follows pause and play mechanism in environment stress recovery in diverse plant species
Hazelwood, O. S.; Diehl, K. A.; Hollenbeck, V.; Herb, D.; Gallagher, J. P.; Ashraf, A.
10.1101/2025.04.02.646900 — plant biology — Posted on 2025-04-06
4241 Outer epidermal edges mediate cell-cell adhesion for tissue integrity in plants
Erguvan, O.; Heymans, A.; Atakhani, A.; Gascon, E.; Smith, R. S.; Ali, O.; Verger, S.
10.1101/2025.04.03.646819 — plant biology — Posted on 2025-04-06
4244 Welcome pathogens: transient heat dampens the responses to acibenzolar-S-methyl beyond defenses in apple plants
Chavonet, E.; Nguyen, B.-h.; Heintz, C.; Cournol, R.; Siroka, J.; Novak, O.; Larbat, R.; Gaucher, M.; Brisset, M.-N.; Pantin, F.; Degrave, A.
10.1101/2025.04.03.647103 — plant biology — Posted on 2025-04-06
4245 Prosystemin-derived signals: bridging leaf microbiome dynamics and defense activation
Castaldi, V.; Wicaksono, W. A.; De Filippis, F.; Berg, G.; Criscuolo, M. C.; Rao, R.
10.1101/2025.04.05.646382 — plant biology — Posted on 2025-04-06
4249 Loss-of-function of the drought-induced genes GASA3 and AFP1 confers enhanced drought tolerance in Arabidopsis thaliana
Bhattacharyya, S.; Turysbek, B.; Lorenz, S. D.; Rosales, D. C.; Shoaib, Y.; Gutbrod, K.; Doermann, P.; Chigri, F.; Vothknecht, U. C.
10.1101/2025.04.03.647048 — plant biology — Posted on 2025-04-06
4251 Temperature signals drive grass secondary cell wall thickening
Gregory, G. A.; Coomey, J. H.; Khahani, B.; Gonze, D.; Omran, S.; McGillivray, K. A.; Stewart, C. E.; Gardner, K. A.; Follette, D.; Hazen, S. P.
10.1101/2025.04.03.647122 — plant biology — Posted on 2025-04-06
4252 High Density Phenotypic Map of Natural Variation for Intermediate Phenotypes Associated with Stalk Lodging Resistance in Maize
Kunduru, B.; Bokros, N. T.; Tabaracci, K.; Kumar, R.; Brar, M. S.; Stubbs, C. J.; Oduntan, Y.; DeKold, J.; Bishop, R. H.; Woomer, J.; Verges, V. L.; McDonald, A.; McMahan, C. S.; DeBolt, S.; Robertson, D. J.; Sekhon, R.
10.1101/2025.04.03.647088 — plant biology — Posted on 2025-04-06
4256 MeCP2 controls dendritic morphogenesis via miR-199a-mediated Qki downregulation
Irie, K.; Nakashima, H.; Yamaguchi, M.; Osakada, F.; Ozaki, N.; Tsujimura, K.; Nakashima, K.
10.1101/2025.04.04.642981 — neuroscience — Posted on 2025-04-06
4261 Giant transposons promote strain heterogeneity in a major fungal pathogen
Gluck-Thaler, E.; Forsythe, A.; Puerner, C.; Gutierrez-Perez, C.; Stajich, J. E.; Croll, D.; Cramer, R. A.; Vogan, A. A.
10.1101/2024.06.28.601215 — microbiology — Posted on 2025-04-06
4262 Device encapsulated MSCs for adaptive secretome therapy to effectively target ischaemic heart injury
Kompa, A.; Greening, D.; Lees, J.; Kong, A. M.; Cross, J.; Nowland, A.; Phang, J.; Naghipour, S.; Deng, Y.; Darby, J. R.; Mariana, L.; Kos, C.; Hall, T.; Newcomb, A.; Chong, J. J.; Ritchie, R.; Morrison, J.; Papas, K.; Kelly, K.; Hausenloy, D.; Loudovaris, T.; Lim, S. Y.
10.1101/2025.04.01.646502 — pathology — Posted on 2025-04-06
4265 Chemical Genomics Language Model toward Reliable and Explainable Compound-Protein Interaction Exploration
Koyama, T.; Tsumura, H.; Okita, R.; Yamazaki, K.; Hasegawa, A.; Imamura, K.; Kato, T.; Iwata, H.; Kojima, R.; Inoue, H.; Matsumoto, S.; Okuno, Y.
10.1101/2024.02.13.580100 — bioinformatics — Posted on 2025-04-06
4266 Forest conversion to cashew orchards delays the diel activity of diurnal mammals in West Africa
Palmeirim, A. F.; Na Mone, D.; Nhasse, I.; Soares, J.; Oliveira, R.; Lopes-Lima, M.; Palma, L.
10.1101/2025.04.01.646119 — ecology — Posted on 2025-04-06
4267 Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in Pseudomonas aeruginosa
Lormand, J. D.; Savelle, C. H.; Teschler, J. K.; Lopez, E.; Little, R. H.; Malone, J.; Yildiz, F. H.; Garcia-Garcia, M. J.; Sondermann, H.
10.1101/2025.03.18.643919 — microbiology — Posted on 2025-04-06
4270 Non-Invasive Quantification of Viability in Spheroids Using Deep Learning
Dubinsky, D.; Harel, S.; Bein, A.; Nyska, A.; Yaari, S.; Koc, B.; Anas, F.; Bentwich, I.; Wolf, L.
10.1101/2025.03.09.642246 — pharmacology and toxicology — Posted on 2025-04-06
4273 Lung architecture amplifies tissue deposition in an agent-based model of fibrotic development
Casey, D. T.; Sosa, A.; Mori, V.; Hall, J.; Suki, B.; Smith, B. J.; Bates, J. H. T.
10.1101/2025.04.01.646600 — systems biology — Posted on 2025-04-06
4275 Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma
Jordana-Urriza, L.; Serrano, G.; Camara-Pena, S.; Calleja-Cervantes, M. E.; San Martin-Uriz, P.; Zabaleta, A.; Oliver-Caldes, A.; Espanol-Rego, M.; Alignani, D.; Lozano, T.; Rodriguez-Diaz, S.; Iglesias, E.; Cabanas, V.; Reguera, J. L.; Gonzalez-Calle, V.; Mateos, M. V.; Sanchez-Guijo, F.; Paiva, B.; Lasarte, J. J.; Inoges, S.; Lopez-Diaz de Cerio, A.; Gonzalez-Navarro, A.; Juan, M.; Fernandez de Larrea, C.; Tamariz, E.; Alfonso-Pierola, A.; Rodriguez-Otero, P.; San-Miguel, J.; Hernaez, M.; Rodriguez-Madoz, J. R.; Prosper, F.
10.1101/2025.04.01.646378 — genomics — Posted on 2025-04-06
4277 GPCR-targeted imaging and manipulation of homeostatic microglia in living systems
Vanaja Chandrasekharan, S.; Chaubey, P.; Khandelwal, S.; Medishetti, R.; Chakraborty, S.; Rajaram, S.; Jayakumar, K.; Latua, P.; Goyal, R.; R, G.; Das, S.; Chatti, K.; Mandal, K.; Tazhe Veetil, A.
10.1101/2025.04.01.646501 — immunology — Posted on 2025-04-06
4278 Intestinal fructose metabolism/GLP-1/β-cell axis counteracts hyperglycemia after short-term fructose ingestion
Murao, N.; Seino, Y.; Morikawa, R.; Hidaka, S.; Haraguchi, T.; Tomatsu, E.; Habara, M.; Ohno, T.; Yokoi, N.; Harada, N.; Hayashi, Y.; Yamada, Y.; Suzuki, A.
10.1101/2025.04.01.646509 — physiology — Posted on 2025-04-06
4279 High-throughput histopathology for complex in vitro models
Harter, M. F.; D'Arcangelo, E.; Aubert, J.; Lavickova, B.; Havnar, C.; Stoll, B.; Cubela, I.; Filip, A. M.; Gaspa-Toneu, L.; Scherer, J.; Karagkiozi, E.; Dupre, J.-S.; Lopez-Sandoval, R.; Hsia, R.; Norona, L.; Brancati, G.; Okuda, R.; Camp, G.; Shamir, E.; Garcia-Cordero, J. L.; Pereiro, I.; Gjorevski, N.
10.1101/2025.04.01.646522 — pathology — Posted on 2025-04-06
4280 Attenuation of mosaic aneuploidy and erroneous first mitotic division of human embryos
Currie, C. E.; Byrska, A.; Taylor, D. M.; Erent, M.; Bakalova, D.; Sun, X.; Koki, C.; Burroughs, N.; Anderson, R.; Marston, A.; Hartshorne, G.; McAinsh, A.
10.1101/2025.04.05.647367 — cell biology — Posted on 2025-04-06
4288 Robust conformational space exploration of cyclic peptides by combining different MD protocols and force fields
Murail, S.; Sawmynaden, J.; Zemirli, A.; Jusot, M.; Pietrucci, F.; Chomilier, J.; Tuffery, P.; Stratmann, D.
10.1101/2025.03.31.646350 — biophysics — Posted on 2025-04-05
4290 Automated Quality Control of Time-Course Imaging from 3D in vitro cultures
Cramer, E.; Lopez-Vidal, T.; Johnson, J.; Wang, V.; Bergman, D.; Weeraratna, A.; Burkhart, R.; Fertig, E. J.; Zimmerman, J. W.; Heiser, L.; Chang, Y. H.
10.1101/2025.03.31.646437 — bioengineering — Posted on 2025-04-05
4295 Using revisitation data for predicting changes in ecosystem functioning across protected and non-protected coastal dunes
La Bella, G.; Acosta, A. T. R.; Jucker, T.; Bazzichetto, M.; Andrello, M.; Sperandii, M. G.; Carboni, M.
10.1101/2025.03.31.646285 — ecology — Posted on 2025-04-05
4297 The effect of MurM and a branched cell wall structure on penicillin resistance in Streptococcus pneumoniae
Gjennestad, R. S.; Heggenhougen, M. V.; Winther, A. R.; Moldstad, J.; Eldholm, V.; Kjos, M.; Haavarstein, L. S.; Straume, D.
10.1101/2025.04.05.647355 — microbiology — Posted on 2025-04-05
4298 Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus
McClary, W. D.; Brandt, D. S.; Jennewein, M. F.; Singh, J.; Beaver, S.; Ykema, M. R.; Press, C.; Melief, E.; Bakken, J.; Fusco, P.; Lo, E.; Battisti, P.; Cross, N.; Kasal, D. N.; Hartwig, A. T.; Casper, C.; Bowen, R. A.; Gerhardt, A.; Voigt, E. A.
10.1101/2025.03.31.646478 — immunology — Posted on 2025-04-05
4300 Endothelial cell Nrf2 controls neuroinflammation following a systemic insult
Zou, H.; Leah, T.; Huang, Z.; He, X.; Mameli, E.; Caporali, A.; Dando, O.; Qiu, J.
10.1101/2024.10.21.619507 — neuroscience — Posted on 2025-04-05
4303 Protocell formation on micrometeorites
Jesorka, A.; Villalmanzo, E. P.; Ciftcioglu, E.; Jedrasik, P.; Larsen, J.; Gozen, I.
10.1101/2025.03.31.646313 — biophysics — Posted on 2025-04-05
4306 Training data composition determines machine learning generalization and biological rule discovery
Ursu, E.; Minnegalieva, A.; Rawat, P.; Chernigovskaya, M.; Tacutu, R.; Sandve, G. K.; Robert, P. A.; Greiff, V.
10.1101/2024.06.17.599333 — bioinformatics — Posted on 2025-04-05
4307 Adjustable Compliance Footwear Technology to Investigate Gait Adaptation
Price, M.; Robbins, C.; Szemethy, S.; Abdikadirova, B.; Olson, G.; Hoogkamer, W.; Huber, M. E.
10.1101/2025.03.31.645746 — bioengineering — Posted on 2025-04-05
4310 Single-cell RNA Sequencing Analysis of Sputum Cell Transcriptomes Reveals Pathways and Communication Networks That Contribute to the Pathogenesis of Asthma
Yan, X.; Liu, Q.; Adams, T. S.; Schupp, J. C.; Li, S.; Huang, S.; Grant, N.; Wilson, G.; Gomez, J. V.; Cohn, L.; Kaminski, N.; Weiss, S.; Tantisira, K.; Chupp, G. L.
10.1101/2025.03.31.646405 — genomics — Posted on 2025-04-05
4314 Somatic mutations in ALS genes in the motor cortex of sporadic ALS patients
Gonzalez-Velasco, O.; Parlato, R.; Yilmaz, R.; Decker, L.; Menge, S.; Freischmidt, A.; Yang, X.; Tulasi, N.; Brenner, D.; Andersen, P. M.; Forsberg, K.; Schlachetzki, J. C. M.; Brors, B.; von Voithenberg, L. V.; Weishaupt, J. H.
10.1101/2025.03.31.646375 — genetics — Posted on 2025-04-05
4316 30S-seq redefines the bacterial Ribosome Binding Site
Jagodnik, J.; Gherdol-Nouvion, V.; Al Sahmarani, M.; Maes, A.; Guillier, M.
10.1101/2025.04.04.647229 — molecular biology — Posted on 2025-04-05
4317 An integrative multi-omics approach points to membrane composition as a key factor in E. coli persistence
Canas-Duarte, S. J.; Sun, L.; Perez-Lopez, M. I.; Herrfurth, C.; Contreras, L. M.; Feussner, I.; Leidy, C.; Paulsson, J.; Riano-Pachon, D. M.; Pedraza, J. M.; Restrepo, S.
10.1101/2020.08.28.271171 — microbiology — Posted on 2025-04-05
4319 Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Dietrich, M.; Chmielewski, J.; Chan, L.-J.; Tan, L. L.; Adair, A.; Lyons, F.; Gabriela, M.; Lopaticki, S.; Dite, T.; Dagley, L.; Pazzagli, L.; Gupta, P.; Kamil, M.; Vaughan, A. M.; Rojrung, R.; Abraham, A.; Mazhari, R.; Longley, R. J.; Zeglinski, K.; Gouil, Q.; Mueller, I.; Fabb, S.; Shandre-Mugan, R.; Pouton, C. W.; Glukhova, A.; Shakeel, S.; Tham, W.-H.
10.1101/2025.02.13.638205 — microbiology — Posted on 2025-04-05
4320 Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis
Kim, S. E.; Abo, H.; Wang, Y.; Winer, S.; Winer, D.; Pellizzon, M.; Ngo, V. L.; Gewirtz, A.
10.1101/2025.03.31.646427 — immunology — Posted on 2025-04-05
4321 Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model
Maiello, P.; Diedrich, C. R.; Rutledge, T.; Rodgers, M.; Kracinovsky, K.; Borish, H. J.; White, A. G.; Hopkins, F.; Chao, M. C.; Klein, E.; Fortune, S. M.; Flynn, J. L.; Lin, P. L.
10.1101/2025.03.31.646419 — immunology — Posted on 2025-04-05
4323 Intradental mechano-nociceptors serve as sentinels that prevent tooth damage
Ronan, E. A.; Gandhi, A. R.; Uchima Koecklin, K. H.; Hu, Y.; Wan, S.; Constantinescu, B. S. C.; Guenther, M. E.; Nagel, M.; Liu, L.-Y.; Jha, A.; Dakhilalla, L.; Blumberg, K. J.; Berthaume, I. T.; Stern, T.; Pipe, K. P.; Ye, B.; Li, P.; Emrick, J. J.
10.1101/2024.05.11.593684 — neuroscience — Posted on 2025-04-05
4325 ANALYSIS OF PHYTOEXTRACTS OF MEDICINAL PLANTS FOR ANTIMICROBIAL ACTIVITY AGAINST PATHOGENIC STRAINS OF MICROORGANISMS
Chokheli, V. A.; Butenko, E. V.; Pokudina, I. O.; Firsova, I. M.; Azarov, A. S.; Belyaev, M. O.; Tsymerskaia, C. A.; Sushkova, S. N.
10.1101/2025.03.31.646455 — pharmacology and toxicology — Posted on 2025-04-05
4326 Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis
Xiao, Y.; Hong, X.; Zhi, L.; Li, Y. N.; Regensburger, M.; Marxreiter, F.; Gorg, B.; Koziel, S.; Gyorfi, A. H.; Filla, T.; Bruch, P. M.; Tripal, P.; Adjaye, J.; Dietrich, S.; Winkler, J.; Distler, J. H. W.; Matei, A. E.
10.1101/2025.03.31.646441 — biophysics — Posted on 2025-04-05
4327 Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals
Saini, M.; Aschenbrenner, J. C.; Ruiz, F. X.; Chopra, A.; Chandran, A. V.; Marples, P. G.; Balcomb, B. H.; Fearon, D.; von Delft, F.; Arnold, E.
10.1101/2025.03.31.646453 — biophysics — Posted on 2025-04-05
4333 Injectable adhesive hydrogel-drug complexes synchronize the release of chemoimmunotherapy to treat brain tumors in mice
Dion, M. Z.; Cryer, A. M.; Dahis, D.; Dosta, P.; Li, A.; Poley, M.; Puigmal, N.; Ling, I.; Carrasco, S.; Hinojosa, A.; Soria, Y.; Tyler, B.; Brem, H.; Artzi, N.
10.1101/2025.03.31.646388 — bioengineering — Posted on 2025-04-05
4334 Identification and Validation of Small Molecules with Mucin-Selective Regiospecific Binding in the Gastrointestinal Tract
Subramanian, D. A.; Kirtane, A. R.; White, G. N.; Freitas, D. E.; Ishida, K.; Jenkins, J.; Pettinari, A.; Morimoto, J.; Fitzgerald, N.; Traverso, G.
10.1101/2025.03.31.646052 — bioengineering — Posted on 2025-04-05
4335 Integrating affinity chromatography in the platform process for Adenovirus purification
Wu, Y.; Barbieri, E.; Smith, W.; Minzoni, A.; Kilgore, R.; Chu, W.; Daniele, M.; Menegatti, S.
10.1101/2025.03.31.646491 — bioengineering — Posted on 2025-04-05
4336 Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by Cryo-EM
Shek, J.; Sun, C.; Wilson, E. M.; Moadab, F.; Hastie, K. M.; Rajamanickam, R. R.; Penalosa, P. J.; Harkins, S. S.; Parakh, D.; Hariharan, C.; Zyla, D. S.; Yu, C.; Shaffer, K. C. L.; Lewis, V. I.; Avalos, R. D.; Mustelin, T.; Ollmann Saphire, E.
10.1101/2025.04.04.647320 — biochemistry — Posted on 2025-04-05
4337 Linoleic acid metabolite, 13-S-hydroxyoctadecadienoic acid, suppresses cancer cell growth by inhibiting mTOR
Park, S. J.; Kwon, H.; Yang, A. Y.; Lee, B.; Lee, H.; Park, S. E.; Lee, S.; Park, B. B.; Kim, Y.; Lee, J.; Oh, B.-C.; Deredge, D.; Wintrode, P. L.; Kim, M.-Y.; Byun, Y.; Kim, S.
10.1101/2025.04.02.646927 — biochemistry — Posted on 2025-04-05
4339 The Mismatch Negativity compared: EEG, SQUID-MEG and novel 4Helium-OPMs
Gutteling, T. P.; Mattout, J.; Daligault, S.; Jung, J.; Labyt, E.; Schwartz, D.; Lecaignard, F.
10.1101/2025.04.04.647154 — neuroscience — Posted on 2025-04-05
4343 Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin
Weiss, E. S.; Hirai, T.; Li, H.; Liu, A.; Baker, S.; Magill, I.; Gillis, J.; Zhang, Y. R.; Ramcke, T.; Kurihara, K.; The ImmGen Consortium OpenSource T cell Project, ; Masopust, D.; Anandasabapathy, N.; Singh, H.; Zemmour, D.; Mackay, L. K.; Kaplan, D. H.
10.1101/2025.03.31.646438 — immunology — Posted on 2025-04-05
4346 A mechanism linking dopamine's roles in reinforcement, movement and motivation
Hamilos, A. E.; Wijsman, I. C.; Ding, Q.; Assawaphadungsit, P.; Ozcan, Z.; Assad, J. A.
10.1101/2025.04.04.647288 — neuroscience — Posted on 2025-04-05
4351 Cumulating MS Signal enables polyclonal antibody analysis
Gueto-Tettay, C. A.; Strobaek, J.; Tang, D.; Gomez Toledo, A.; Karami, Y.; Khakzad, H.; Malmstrom, J.; Malmstrom, L.
10.1101/2025.03.31.645874 — bioinformatics — Posted on 2025-04-05
4357 Neuronal expression of S100B triggered by oligomeric Aβ peptide protects against cytoskeletal damage and synaptic loss
Saavedra, J.; Nascimento, M.; Figueira, A. J.; Oliveira da Silva, M. I.; Giao, T.; Oliveira, J.; Liz, M. A.; Gomes, C. M.; Cardoso, I.
10.1101/2025.04.04.647260 — neuroscience — Posted on 2025-04-05
4361 PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response
Ojeda-Juarez, D.; Funk, G.; Richards, E.; Rajic, A. J.; McClatchy, D. B.; Soldau, K.; Chen, X.; Yates, J. R.; Gonias, S. L.; Sigurdson, C. J.
10.1101/2025.04.01.645054 — neuroscience — Posted on 2025-04-05
4364 A novel rat model for human Meibomian gland dysfunction and ocular rosacea
Zhu, L.; Rodrigues-Braz, D.; Gelize, E.; Crepin, M.; Peltier, C.; Lheure, C.; Morel, X.; Bourges, J.-L.; Berdeaux, O.; Behar-Cohen, f.; ZHAO, M.
10.1101/2025.03.31.646002 — pathology — Posted on 2025-04-05
4365 The Effects of DMSO on DNA Conformations and Mechanics
Storm, K. R.; Korosy, C.; Skoruppa, E.; Pritzl, S. D.; Kolbeck, P. J.; Vanderlinden, W.; Schiessel, H.; Lipfert, J.
10.1101/2025.03.31.646418 — biophysics — Posted on 2025-04-05
4367 Hexapods shift to increasingly stable gaits when climbing on inclined substrates
Riiska, C. A.; Harrison, J. S.; Thompson, R. D.; Nina, J. Q.; Gallice, G. R.; Rieser, J. M.; Bhamla, S.
10.1101/2025.04.04.647231 — animal behavior and cognition — Posted on 2025-04-05
4368 RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis
Han, A.; Yermalovich, A.; Najia, M. A. T.; Pearson, D. S.; Fujiwara, Y.; Bolgov, M.; Kubaczka, C.; North, T. E.; Lundin, V.; Orkin, S.; Daley, G. Q.
10.1101/2025.04.03.647020 — developmental biology — Posted on 2025-04-05
4369 Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain
Li, Y.; Squillace, S.; Schafer, R.; Giancotti, L. A.; Chen, Z.; Egan, T. M.; Hoft, S. G.; DiPaolo, R. J.; Salvemini, D.
10.1101/2025.04.03.642851 — neuroscience — Posted on 2025-04-05
4370 A Tonotopic Regulatory Axis Governing Isoform-Specific MYO7A Expression in Cochlear Hair Cells
Li, S.; Jun, S.; Kim, Y.; Gogineni, A.; Lee, F.; Kim, C. H.; Kim, U.-K.; Peng, A. W.; Shin, J.-B.
10.1101/2025.04.04.647241 — neuroscience — Posted on 2025-04-05
4371 An engine for systematic discovery of cause-effect relationships between brain structure and function
Luppi, A. I.; Milisav, F. I.; Suarez, L. E.; Shafiei, G.; Vohryzek, J.; Sanz Perl, Y.; Ali, H.; Rosas, F. E.; Mediano, P. A. M.; Misic, B.; Deco, G.; Kringelbach, M. L.
10.1101/2025.04.05.647237 — neuroscience — Posted on 2025-04-05
4372 Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord
Tucker, A.; Eisdorfer, J. T.; Thackray, J. K.; Vo, K.; Thomas, H.; Tandon, A.; Moses, J.; Singletary, B.; Gillespie, T.; Smith, A.; Pauken, A.; Nadella, S.; Pitonak, M.; Letchuman, S.; Jang, J.; Totty, M.; Jalufka, F. L.; Aceves, M.; Adler, A. F.; Maren, S.; Blackmon, H.; McCreedy, D. A.; Abraira, V. E. G.; Dulin, J. N.
10.1101/2025.04.05.644402 — neuroscience — Posted on 2025-04-05
4373 Associations between fluid biomarkers and PET imaging (UCB-J) of synaptic pathology in Alzheimer's disease
Nilsson, J.; Mecca, A.; Ashton, N. J.; Salardini, E.; Odell, R.; Carson, R.; Benedet, A.; Blennow, K.; Zetterberg, H.; Van Dyck, C.; Brinkmalm, A.
10.1101/2025.03.31.646290 — neuroscience — Posted on 2025-04-05
4375 A persistent increase in gut permeability correlates with emotional dysregulation following maternal separation in male and female mice.
Castro-Zavala, A.; Nieto-Nieves, A.; Melgar-Locatelli, S.; Medina-Rodriguez, L.; Manas-Padilla, M. C.; Castilla-Ortega, E.
10.1101/2025.04.04.647178 — neuroscience — Posted on 2025-04-05
4380 MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations
Nasim, S.; Baig, M.; Wylie-Sears, J.; Vivero, M.; Smits, P.; Marrs, L.; Cheng, Y. S.; Alves, C.; Pinto, A.; Greene, A. K.; Bischoff, J.
10.1101/2025.03.31.646063 — pathology — Posted on 2025-04-05
4382 Sustained learned immunosuppression could not prevent local allergic ear swelling in a rat model of contact hypersensitivity
Salem, Y.; Leisengang, S.; Jakobs, M.; Dombrowski, K.; Bihorac, J.; Heiss-Lueckemann, L.; Wenzlaff, S.; Trautmann, L.; Hagenacker, T.; Schedlowski, M.; Hadamitzky, M.
10.1101/2025.04.05.647348 — animal behavior and cognition — Posted on 2025-04-05
4383 The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity
Mouillet, J.-F.; Ouyang, Y.; Sadovsky, E.; Kothandan, V. K.; Sorenson, H. L.; Badeau, L. J.; Sarkar, S. N.; Chu, T.; Sorkin, A.; Sadovsky, Y.
10.1101/2025.04.03.647038 — developmental biology — Posted on 2025-04-05
4385 Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration
PATNI, A. P.; Mout, R.; Moore, R.; Alghadeer, A. A.; Daley, G. Q.; Baker, D.; Mathieu, J.; Ruohola-Baker, H.
10.1101/2025.04.03.646929 — developmental biology — Posted on 2025-04-05
4387 G-quadruplex profiling in complex tissues using single-cell CUT&Tag
Lyu, J.; Hetey, S.; Castelo-Branco, G.; Bartosovic, M.; Elsässer, S. J.
10.1101/2025.04.03.647101 — developmental biology — Posted on 2025-04-05
4389 The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapy
Hagen, M. W.; Setiawan, N. J.; Dexter, S. L.; Woodruff, K. A.; Gaerlan, F. K.; Orozco, J. J.; Termini, C. M.
10.1101/2025.04.04.645037 — cell biology — Posted on 2025-04-05
4390 Obesity promotes urinary tract infection by disrupting urothelial immune defenses
Schwartz, L.; Salamon, K.; Simoni, A.; Cotzomi-Ortega, I.; Sanchez-Zomora, Y.; Linn-Peirano, S.; John, P.; Ruiz-Rosado, J. d. D.; Jackson, A. R.; Wang, X.; Spencer, J. D.
10.1101/2025.04.04.647270 — cell biology — Posted on 2025-04-05
4391 Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity
Kline, G. M.; Boinon, L.; Guerrero, A.; Kutseikin, S.; Cruz, G.; Williams, M. P.; Paxman, R. J.; Balch, W. E.; Kelly, J. W.; Mu, T.; Wiseman, L.
10.1101/2025.04.04.646800 — cell biology — Posted on 2025-04-05
4392 Integrin-TGFβ axis induces partial EMT in basal-like cells to lead collective invasion
El-Gammal, A.; Jansen, L.; Verhagen, M. P.; Kremer, H.; Soufi, S.; Masoudnia, M.; Westland, D.; Bult, P.; Fodde, R.; Verstegen, M. M. A.; Gloerich, M.; van Mil, S. W. C.; Khalil, A. A.
10.1101/2025.04.04.647177 — cell biology — Posted on 2025-04-05
4394 β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function
Anderson, P.; Xiao, P.; Zhong, Y.; Kaakati, A.; Alfonso-DeSouza, J.; Zhang, T.; Zhang, C.; Qi, L.; Ding, W.; Liu, S.; Pani, B.; Krishnan, A.; Chen, O.; Jassal, C.; Strawn, J.; Sun, J.; Rajagopal, S.
10.1101/2025.04.05.647240 — cell biology — Posted on 2025-04-05
4396 Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis
Huang, K.; Miao, T.; Dantas, E.; Han, M.; Hu, Y.; Wang, K.; Sanford, J.; Goncalves, M.; Perrimon, N.
10.1101/2025.04.04.647255 — cell biology — Posted on 2025-04-05
4397 Smart hybrid microscopy for cell-friendlydetection of rare events
Stepp, W. L.; Durmus, E. B.; Rodriguez Alvarez, S. N.; Landoni, J. C.; Tortarolo, G.; Douglass, K. M.; Weigert, M.; Manley, S.
10.1101/2025.04.04.647219 — cell biology — Posted on 2025-04-05
4400 Dynamic transcriptional heterogeneity in pituitary corticotrophs
Yuan, Z.; Laiho, L.; Smith, E.; McDougall, C.; Duncan, P. J.; Le Tissier, P.; Shipston, M. J.; Romano, N.
10.1101/2025.04.04.645979 — cell biology — Posted on 2025-04-05
4402 Automated sleep scoring in hibernating and non-hibernating American black bears
Toien, O.; Pittaras, E. C.; Huang, Y.-G.; Brodersen, P. J. N.; Allocca, G.; Barnes, B. M.; Heller, H. C.
10.1101/2025.03.31.646262 — neuroscience — Posted on 2025-04-05
4403 Genetic risk in endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease
Mamde, S.; Rose, S.; Prater, K. E.; Cochoit, A.; Lin, Y. F.; Smith, I.; Johnson, C. S. C.; Reid, A.; Qiu, W.; Strohbehn, S.; Keene, C. D.; Rolf, B.; Lin, K.; Lee, S.-I.; Garden, G.; Blue, E.; Young, J. E.; Jayadev, S.
10.1101/2025.03.16.643481 — neuroscience — Posted on 2025-04-05
4404 DNA Specimen Preservation using DESS and DNA Extraction in Museum Collections: A Case Study Report
Ogiso-Tanaka, E.; Shimada, D.; Ogawa, A.; Ishiyama, G.; Okumura, K.-i.; Hosaka, K.; Ishii, C.; Nam, K.-O.; Hoshino, M.; Nomura, S.; Kakizoe, S.; Nakamura, Y.; Nishiumi, I.; Ito, M. A.; Kitayama, T.; Tanaka, N.; Hosoya, T.; Jinbo, U.
10.1101/2025.03.30.646169 — zoology — Posted on 2025-04-05
4405 Cellular dynamics under time-varying conditions
Joshi, K.; Roy, S.; Biswas, R. R.; Iyer-Biswas, S.
10.1101/2023.03.07.531540 — biophysics — Posted on 2025-04-05
4406 PanSpace: Fast and Scalable Indexing for Massive Bacterial Databases
Avila Cartes, J. E.; Ciccolella, S.; Denti, L.; Dandinasivara, R.; Della Vedova, G.; Bonizzoni, P.; Schonhuth, A.
10.1101/2025.03.19.644115 — genomics — Posted on 2025-04-05
4407 Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus
Card, K. J.; Crozier, D.; Durmaz, A.; Gray, J. M.; Creary, J.; Stocks, A.; Maltas, J. A.; Bonomo, R. A.; Burke, Z. D. C.; Scott, J. G.
10.1101/2023.11.30.569373 — evolutionary biology — Posted on 2025-04-05
4409 The Spc105-Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of the Ipl1/Aurora B kinase
Dudziak, A.; Pleuger, R.; Schmidt, J.; Hamm, F.; Tendulkar, S.; Jaenen, K.; Vetter, I. R.; Singh, S.; Fischboeck, J.; Herzog, F.; Westermann, S.
10.1101/2024.10.01.615642 — cell biology — Posted on 2025-04-05
4410 Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Lee, K. K.; Lapinska, U.; Tolle, G.; Micaletto, M.; Zhang, B.; Phetsang, W.; Verderosa, A.; Invergo, B. M.; Westley, J.; Bebes, A.; Yuecel, R.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; van Houte, S.; Caboni, P.; Blaskovich, M.; Housden, B.; Tsaneva-Atanasova, K.; Pagliara, S.
10.1101/2024.04.22.590445 — microbiology — Posted on 2025-04-05
4411 Drug treatment alters performance in a neural microphysiological system of information processing
Watmuff, B.; Habibollahi, F.; Desouza, C.; Khajehnejad, M.; Loeffler, A.; Baranes, K.; Poulin, N.; Kotter, M.; Kagan, B.
10.1101/2025.01.27.635163 — neuroscience — Posted on 2025-04-05
4412 Mimicking opioid analgesia in cortical pain circuits
Oswell, C. S.; Rogers, S. A.; James, J. G.; McCall, N. M.; Hsu, A. I.; Salimando, G. J.; Mahmood, M.; Wooldridge, L. M.; Wachira, M.; Jo, A.; Sandoval Ortega, R. A.; Wojick, J. A.; Beattie, K.; Farinas, S. A.; Chehimi, S. N.; Rodrigues, A.; Ejoh, L. L.; Kimmey, B. A.; Lo, E.; Azouz, G.; Vasquez, J. J.; Banghart, M. R.; Beier, K. T.; Creasy, K. T.; Ramakrishnan, C.; Crist, R. C.; Reiner, B. C.; Deisseroth, K.; Yttri, E. A.; Corder, G.
10.1101/2024.04.26.591113 — neuroscience — Posted on 2025-04-05
4414 Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young males and females
Graham, Z. A.; Pathak, K. V.; Garcia-Mansfield, K.; Lavin, K.; Torres, A.; McAdam, J.; Broderick, T.; Pirrotte, P.; Bamman, M.
10.1101/2024.08.16.608249 — physiology — Posted on 2025-04-05
4415 Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure
Weiss, R. C.; Pyles, K. D.; Cho, K.; Brennan, M.; Fisher, J. S.; Patti, G. J.; McCommis, K. S.
10.1101/2024.06.06.597841 — physiology — Posted on 2025-04-05
4416 BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment
Rios-Jimenez, E.; Zomer, A.; Collot, R.; Barrera Roman, M.; Ariese, H.; L. van Ineveld, R.; Kleinnijenhuis, M.; Bessler, N.; Johnson, H.; Dawson, C.; Rios, A.; Alieva, M.
10.1101/2024.08.23.609358 — cancer biology — Posted on 2025-04-05
4417 HyDrop v2: Scalable atlas construction for training sequence-to-function models
Dickmänken, H.; Wojno, M.; Theunis, K.; Eksi, E. C.; Mahieu, L.; Christiaens, V.; Kempynck, N.; De Rop, F. V.; Roels, N.; Spanier, K. I.; Vandepoel, R.; Hulselmans, G. J.; Poovathingal, S.; Aerts, S.
10.1101/2025.04.02.646792 — bioinformatics — Posted on 2025-04-05
4423 MeCP2 controls dendritic morphogenesis via miR-199a-mediated Qki downregulation
Irie, K.; Nakashima, H.; Yamaguchi, M.; Osakada, F.; Ozaki, N.; Nakashima, K.; Tsujimura, K.
10.1101/2025.04.04.642981 — neuroscience — Posted on 2025-04-05
4425 Individual differences in sequential decision-making
Abbaszadeh, M.; Ozanick, E.; Magen, N.; Darrow, D. P.; Yan, X.; Herman, A.; Ebitz, B.
10.1101/2025.04.04.647306 — neuroscience — Posted on 2025-04-05
4426 Glucocorticoid receptors mediate reprogramming of astrocytes in depression.
Dalbeyler, S.; Herud, A.; Zglinicki, B.; Ziuzia, P.; Piechota, M.; Hoinkis, D.; Bergauer, L.; Pando, C. M.; Soltys, Z.; Hanus, P.; Groves, P.; Dixon, L.; Ganglberger, F.; Del Prete, D.; Dubovyk, V.; Assfalg, M.; Violet, C.; Lawless, N.; Kielbasa, S. M.; Sigrist, H.; Pryce, C.; Turecki, G.; Schmidt, M. V.; Benes, V.; Kuner, T.; Korostynski, M.; Hengerer, B.; Slezak, M.
10.1101/2025.04.04.646549 — neuroscience — Posted on 2025-04-05
4428 Functional interrogation of neuronal connections by chemoptogenetic presynaptic ablation
Sharma, H.; Robea, M. A.; McGrory, N. H.; Bazan, D. C.; Burton, E. A.; Burgess, H. A.
10.1101/2025.04.04.647277 — neuroscience — Posted on 2025-04-05
4430 A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells
Hamadou, M. H.; Alunno, L.; Venturelli, T.; Valentini, S.; Dalfovo, D.; Lorenzini, F.; Mattivi, A.; Vigorito, V.; Grupelli, G. P.; Matte', A.; Gatto, P.; Pancher, M.; Valentini, C.; De Sanctis, V.; Bertorelli, R.; Marcel, V.; Cusanelli, E.; Freddi, S.; Bertalot, G.; Zaccara, S.; Mione, M.; Fava, L. L.; Romanel, A.; Inga, A.
10.1101/2025.04.02.646512 — molecular biology — Posted on 2025-04-04
4432 Assay for Rapid Quantification of Capped and Tailed Intact mRNA
Gao, R. Y.; Hu, T.; Taylor, A. W.; Lacey, R.; Thomas, K. N.; McCormick, C.; Miller, D. F.; Rowlen, K. L.; Dawson, E. D.
10.1101/2025.04.02.646833 — molecular biology — Posted on 2025-04-04
4435 Enhancing Tissue-Specific Antiviral Immunity to Disrupt Arbovirus Transmission by Mosquitoes
Dong, S.; Ciomperlik-Patton, J.; Zhao, Y.; Dong, Y.; Myles, K. M.; Dimopoulos, G.
10.1101/2025.04.04.647234 — microbiology — Posted on 2025-04-04
4436 Navigating Neurological Re-emergence in Feline Infectious Peritonitis: Challenges and Insights from GS-441524 and Remdesivir Treatment
de Witt Curtius, C. C.; Rodary, M.; Hofmann-Lehmann, R.; Spiri, A. M.; Meli, M. L.; Crespo Bouzon, A.; Wenk, J.; Cerchiaro, I.; Pineroli, B.; Pot, S. A.; Beckmann, K.; Chan, T.; Wieser, M.; Unterer, S.; Felten, S.; Meunier, S. M.
10.1101/2025.04.04.646959 — microbiology — Posted on 2025-04-04
4437 Suppressing selection for antibiotic resistance in the environment: A transparent, ecology-based approach to predicted no-effect concentrations
Kneis, D.; de la Cruz Barron, M.; Konyali, D.; Westphal, V.; Schröder, P.; Westphal-Settele, K.; Schönfeld, J.; Jungmann, D.; Berendonk, T. U.; Klümper, U.
10.1101/2025.04.04.647007 — microbiology — Posted on 2025-04-04
4441 Optimized pipeline for generating highly potent neutralizing Affitins: application to SARS-CoV-2 spike protein
Maurice, T.; Laporte, M.; Barquilla, N.; Fortun, A.; Echasserieau, K.; Guivel-Benhassine, F.; Barbosa, A.; Cossard, P.; Planchais, C.; Anna, F.; Charneau, P.; Mouquet, H.; Roque, C.; Schwartz, O.; Mouratou, B.; Davodeau, F.; Bernardeau, K.; Monel, B.; Pecorari, F.
10.1101/2025.04.03.646589 — biochemistry — Posted on 2025-04-04
4443 Molecular basis for multidrug efflux by an anaerobic RND transporter
Lawrence, R.; Athar, M.; Uddin, M. R.; Adams, C.; Sousa, J.; Durrant, O.; Lellman, S.; Sutton, L.; Keevil, C. W.; Patel, N.; Prosser, C.; McMillan, D.; Zgurskaya, H. I.; Vargiu, A. V.; Ahdash, Z.; Reading, E.
10.1101/2025.04.04.646765 — biochemistry — Posted on 2025-04-04
4444 Complex carbohydrates catabolism capacity of bladder microbiota inhabiting healthy and overactive female bladders
Gourdine, J.-P.; Pacentine, I. V.; Barstad, A.; Dahl, E. M.; Gregory, W. T.; Wolfe, A. J.; Sysoeva, T. A.; Karstens, L.
10.1101/2025.04.02.646827 — biochemistry — Posted on 2025-04-04
4445 Adaptively integrated sequencing and assembly of near-complete genomes
Gamaarachchi, H.; Stevanovski, I.; Hammond, J. M.; Reis, A. L. M.; Rapadas, M.; Jayasooriya, K.; Russell, T.; Yeow, D.; Hort, Y.; Mallett, A. J.; Stackpoole, E.; Roman, L.; Silver, L. W.; Hogg, C. J.; Streeting, L.; Bogdanovic, O.; Rodrigues, R.; Nascimento, L.; Cardoso, A. L.; Georges, A.; Cheng, H.; Patel, H. R.; Kumar, K. R.; Mallawaarachchi, A. C.; Deveson, I. W.
10.1101/2025.03.31.646505 — genomics — Posted on 2025-04-04
4451 Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants
Ahmed, A. Y. M.; Rajai, A.; Fullwood, C.; Rivett, D. W.; McLaughlin, J.; van der Gast, C.; Marsh, R.
10.1101/2025.04.04.647187 — microbiology — Posted on 2025-04-04
4453 Genetic modification of intractable staphylococcal clones by heat-shock facilitated phage transduction
Schulze, L.; Moessner, J.; Krauss, S.; Harbig, T. A.; Nieselt, K.; Krismer, B.; Peschel, A.
10.1101/2025.04.04.647181 — microbiology — Posted on 2025-04-04
4454 GH25 lysozyme mediates tripartite interkingdom interactions and microbial competition on the plant leaf surface
Sorger, Z.; Sengupta, P.; Beier-Heuchert, K.; Bautor, J.; Parker, J. E.; Kemen, E.; Doehlemann, G.
10.1101/2025.04.04.647216 — microbiology — Posted on 2025-04-04
4455 Ebola's Hidden Target: Virus Transmission to and Accumulation within Skin
Richards, P. T.; Fleck, A.; Patel, R.; Fakhimi, M.; Bohan, D.; Geohegan-Barek, K.; Stolte, A. E.; Messingham, C. O.; Connell, S.; Crowe, T.; Gourronc, F. A.; Carrion, R.; Griffiths, A.; Meyerholz, D. K.; Klingelhutz, A. J.; Davey, R. A.; Messingham, K. N.; Maury, W.
10.1101/2025.04.04.647113 — microbiology — Posted on 2025-04-04
4456 Boosting Bug Farms: A Meta-Analysis on Probiotic Effects in Insect Rearing
Haebermann, J.; Antunes, B.; Haase, H.; Rolff, J.; Keil, C.; Rafaluk, C.
10.1101/2025.04.04.647199 — microbiology — Posted on 2025-04-04
4458 Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1
Hariharan, V.; White, J. A.; Dragoni, F.; Fray, E. J.; Pathoulas, N.; Moskovljevic, M.; Zhang, H.; Singhal, A.; Lai, J.; Beg, S. A.; Scully, E. P.; Gilliams, E. A.; Block, D. S.; Keruly, J.; Moore, R. D.; Siliciano, J. D.; Simonetti, F. R.; Siliciano, R. F.
10.1101/2025.04.04.647291 — microbiology — Posted on 2025-04-04
4460 Infant CD4 T-cell response to SARS-CoV-2 mRNA vaccination is restricted in cytokine production and modified by vaccine manufacturer
Peters, M. Q.; Young, A. L.; Stolarczuk, J. E.; Glad, M.; Layton, E.; Logue, J. K.; Minkah, N. K.; Chu, H. Y.; Englund, J. A.; Sather, N.; Seshadri, C.; Kachikis, A.; Harrington, W. E.
10.1101/2025.04.02.646864 — immunology — Posted on 2025-04-04
4464 Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice
Klaile, E.; Müller, M. M.; Sonnberger, J.; Bothe, A.-K.; Brehme, S.; Ehrenpfordt, J.; Klassert, T.; Kuhn, S.; Dietert, K.; Kershaw, O.; Praetorius, J.-P.; Figge, M. T.; Bauer, T.; Gebhardt, A.; Mall, G.; Jacobsen, I. D.; Slevogt, H.
10.1101/2025.03.29.646107 — immunology — Posted on 2025-04-04
4467 BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus
Ning, G.; Lin, Y.; Ma, H.; Zhang, J.; Yang, L.; Liu, Z.; Li, L.; He, X.; Wang, Q.
10.1101/2024.07.17.603892 — developmental biology — Posted on 2025-04-04
4470 A proteogenomic tool uncovers protein markers for human microglial states
Haage, V.; Bautista, A. R.; Tuddenham, J. F.; Marshe, V.; Chiu, R.; Liu, Y.; Lama, T.; Kelly, S. S.; Parghi, N. A.; Park, J.; Buonfiglioli, A.; Furnari, J. L.; Haq, I.; Pearse, R.; Patel, R.; Terzioglu, G.; Touil, H.; Zeng, L.; Noble, J.; Sarkis, R. A.; Shneider, N. A.; de Witte, L.; Schneider, J. A.; Teich, A.; Young-Pearse, T. L.; Riley, C.; Bennett, D. A.; Canoll, P.; Bruce, J. N.; Howden, A. J.; Lloyd, A. F.; De Strooper, B. F.; Sher, F.; Sproul, A. A.; Olah, M.; Taga, M.; Zhang, Y.; Caisheng, L.; Fujita, M.; Petyuk, V. A.; De Jager, P. A.
10.1101/2025.03.31.646212 — neuroscience — Posted on 2025-04-04
4475 Spatial transcriptomics AI agent charts hPSC-pancreas maturation in vivo
Lin, Z.; Wang, W.; Marin-Llobet, A.; Li, Q.; Pollock, S. D.; Sui, X.; Aljovic, A.; Lee, J.; Baek, J.; Liang, N.; Zhang, X.; Wang, C. K.; Huang, J.; Liu, M.; Gao, Z.; Sheng, H.; Du, J.; Lee, S. J.; Wang, B.; He, Y.; Ding, J.; Wang, X.; Alvarez, J. R.; Liu, J.
10.1101/2025.04.01.646731 — genomics — Posted on 2025-04-04
4477 A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
Srivastava, N.; Vomund, A.; Peterson, O.; Yang, Y.; Turicek, D. P.; Zulkifli, A.; Abousaway, O.; Li, T.; Kain, L.; Stone, P.; Ansar, A.; Clement, C.; Sharma, S.; Zhang, B.; Liu, C.; Joglekar, A.; Hu, H.; Hsieh, C.-S.; Campisi, L.; Santambrogio, L.; Teyton, L.; Unanue, E. R.; Arbelaez, A. M.; Lichti, C.; Wan, X.
10.1101/2024.11.07.622538 — immunology — Posted on 2025-04-04
4480 Optical recordings of synaptic vesicle fusion reveal diffusional dispersion
Lehrich, J.; Glyvuk, N.; Duan, J.; Krishnan, S.; Tsytsyura, Y.; Keller, U.; Sunil, L. P.; Nosov, G.; Hueve, J.; Selenschik, P.; Reissner, C.; Missler, M.; Kahms, M.; Klingauf, J.
10.1101/2025.03.31.646326 — neuroscience — Posted on 2025-04-04
4484 Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer
Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.
10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-04-04
4485 Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions
Khan, S. M.; Wang, A. Z.; Desai, R. R.; McCornack, C. R.; Sun, R.; Dahiya, S. M.; Foltz-Stringfellow, J.; Sherpa, N. D.; Leavitt, L.; West, T. R.; Wang, A. F.; Krbanjevic, A.; Choi, B. D.; Leuthardt, E. C.; Patel, B.; Charest, A.; Kim, A. H.; Dunn, G. P.; Petti, A. A.
10.1101/2025.04.04.647096 — cancer biology — Posted on 2025-04-04
4486 Generalizable Neural Models of Emotional Engagement and Disengagement
Nanni Zepeda, M.; Evans, T.; Jagger-Rickels, A.; Raz, G.; Hendler, T.; Fan, Y.; Grimm, S.; Walter, M.; Esterman, M.; Zuberer, A.
10.1101/2024.02.15.579332 — neuroscience — Posted on 2025-04-04
4487 Endocrine modulation of cortical and retinal blood flow across the menstrual cycle
Wright, M. E.; Crofts, C.; Davies, S.; Chandler, H. L.; Driver, I. D.; Germuska, M.; Giarratano, Y.; Rashid, D.; Bernabeu, M. O.; Terry, L.; Steventon, J. J.; Murphy, K.
10.1101/2024.12.19.629235 — neuroscience — Posted on 2025-04-04
4491 UnitRefine: A Community Toolbox for Automated Spike Sorting Curation
Jain, A.; Greene, R.; Halcrow, C.; Swann, J.; Kleinjohann, A.; Spurio, F.; Graff, S.; Kampa, B.; Gall, J.; Gruen, S.; Buccino, A. P.; Hennig, M. H.; Musall, S.
10.1101/2025.03.30.645770 — neuroscience — Posted on 2025-04-04
4495 Presence of an unfamiliar peer reverses escalated cocaine intake in male rats: involvement of the subthalamic nucleus
Vielle, C.; Vignal, L.; Tiran-Cappello, A.; Meffre, J.; Maurice, N.; Degoulet, M.; Brocard, C.; Pelletier, F.; Pelloux, Y.; Baunez, C.
10.1101/2023.02.07.527550 — neuroscience — Posted on 2025-04-04
4496 Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit
Guerrero Quiles, C.; Gonzalez Abalos, J.; Foussat, A. S.; Olympitis, A.; Lodhi, T.; Smith, V.; Reardon, M.; Shabbir, R.; Lunj, S.; Reeves, K.; Baker, A.; Eyres, M.; Marshall, G.; Smith, T.; Hoskin, P.; James, N.; Hall, E.; Huddart, R.; Porta, N.; Biolatti, V.; Humphries, J. D.; Humphries, M.; Choudhury, A.; West, C.
10.1101/2025.04.04.647191 — cancer biology — Posted on 2025-04-04
4497 Lysophosphatidic acid controls autotaxin binding to 1-integrin: impact on disease progression in murine collagen-induced arthritis.
Emery, M.; Cuero, C. N.; Bouazza, L.; Internicola, C.; Duboeuf, F.; Cerecero-Aguirre, P.; McCarthy, A. A.; Machuca-Gayet, I.; Leblanc, R.; Peyruchaud, O.
10.1101/2025.04.04.646839 — cell biology — Posted on 2025-04-04
4498 Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition
Permana, A.; Permana, J. J.; Nellissen, L.; Prayogi, E. S.; Prasetyo, D.; Wich, S. A.; van Schaik, C. P.; Schuppli, C.
10.1101/2025.04.04.646832 — animal behavior and cognition — Posted on 2025-04-04
4499 BRCA1 is a molecular correlate of cell proliferation in human brain development and in Group 3 and 4 medulloblastoma
Cheong, I.; Sun, X.; Lau, L.; Kishore, N.; Senff-Ribeiro, A.; Diaz-Navarro, A.; Hajari, H.; Mak, E.; Ahluwalia, R.; Bianchini, L.; Singh Sandhu, J.; Taylor, M. D.; Kutscher, L.; Stein, L. D.; Pai, S.
10.1101/2025.04.03.646803 — genomics — Posted on 2025-04-04
4500 Brain Network Segregation is Associated with Drug Use Severity in Individuals with Opioid Use Disorder
Hager, N. M.; Wang, X.; Ramos-Ralon, A. P.; Childress, A. R.; Langleben, D. D.; Wiers, C. E.; Shi, Z.
10.1101/2025.04.02.646889 — neuroscience — Posted on 2025-04-04
4501 BABA: Naturalistic fMRI and MEG recordings during viewing of a reality TV show
Li, J.; Wang, Q.; Wang, Y.; Wang, C.; Ma, Z.; Xu, R.; Feng, S.; Jiang, X.; Meng, Z.
10.1101/2025.04.03.646958 — neuroscience — Posted on 2025-04-04
4502 Mice lacking the endocannabinoid-synthesizing enzyme NAPE-PLD exhibit sex-dependent dysregulations in responsiveness to oxycodone and a natural reward
Woodward, T. J.; Sizemore, E. F.; Balaji, A.; Port, A. L.; Hainline, J. J.; Kazi, H.; Luquet, S.; Mackie, K.; Hohmann, A. G.
10.1101/2025.04.03.646908 — neuroscience — Posted on 2025-04-04
4503 Prominent white matter related abnormalities associated with diverse molecular alterations in a mouse model of Col4a1 cerebral small vessel disease.
Brezzo, G.; Pokhilko, A.; Moss, J.; Koudelka, J.; Jansen, M. A.; Lennen, R.; Thompson, G.; Konstantinidou, S. M.; Yau, J.; Boland, E.; Williams, A.; Allan, S. M.; Granata, A.; Sinha, S.; Wang, T.; Markus, H. S.; Fisher, R.; Cader, M. Z.; Van Agtmael, T.; Horsburgh, K.
10.1101/2025.04.04.647207 — neuroscience — Posted on 2025-04-04
4506 Dual-site beta transcranial alternating current stimulation during a bimanual coordination task modulates functional connectivity between motor areas
Gann, M. A.; Paparella, I. A.; Zich, C.; Grigoras, I.; Huertas-Penen, S.; Rieger, S. W.; Thielscher, A.; Sharott, A.; Stagg, C. J.; Schwab, B. C.
10.1101/2025.04.04.647211 — neuroscience — Posted on 2025-04-04
4507 Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)
Schwarz, P. F.; Perhal, A. F.; Preglej, T.; Breit, L.; Schmetterer, K. G.; Grienke, U.; Janneschütz, J.; Chen, Y.; Rochel, N.; Kirchmair, J.; Schützenmeister, N.; Rollinger, J. M.; Bonelli, M.; Dirsch, V. M.
10.1101/2025.04.01.646598 — pharmacology and toxicology — Posted on 2025-04-04
4508 Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases
Mastrogiacomo, D. M.; Price, A.; Fu, Y.; Banerjee, R.; Knauer, L. A.; Li, K.; Yang, Y.; Davis, G. E.; Dellinger, M.; Scallan, J. P.
10.1101/2025.04.02.646922 — pathology — Posted on 2025-04-04
4509 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-04-04
4513 Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.
Fu, Q.; Remes, P. M.; Lee, J.; Jacob, C.; Li, D.; Vegensna, M.; Raedschelders, K.; Haghani, A.; Mengesha, E.; Debbas, P.; Hoedt, E.; Joung, S.; Cheng, S.; Peterman, S.; Fert-Bober, J.; Melmed, G. Y.; McGovern, D. P. B.; Murray, C. I.; Van Eyk, J. E.
10.1101/2025.04.02.646850 — biochemistry — Posted on 2025-04-04
4515 Population structure and domestication history of the Javan banteng (Bos javanicus javanicus)
Wang, X.; Aninta, S. G.; Garcia-Erill, G.; Li, Z.; Khan, A.; Liu, X.; Bertola, L. D.; Dharmayanthi, A. B.; Yulianto, ; Yonathan, ; Rossi, C.; Cauble-Sims, R.; Rosen, B. D.; Hagen, D. E.; Heaton, M. P.; Smith, T. P. L.; Lenstra, J. A.; Martins, N. F. G.; Sinding, M.-H. S.; Agil, M.; Purwantara, B.; Hvilsom, C.; Semiadi, G.; Heller, R.
10.1101/2025.04.01.646613 — evolutionary biology — Posted on 2025-04-04
4516 DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases
Zeng, Y.; Young, O.; Xiong, Q.; Si, L.; Ku, M. W.; Bernier, S.; Dembele, H.; Isinelli, G.; Gilboa, T.; Swank, Z.; Seok, S. H.; Rajwar, A.; Jiang, A.; Zhai, Y.; Williams, L.; Hellman, C.; Wintersinger, C.; Graveline, A.; Vernet, A.; Sanchez, M.; Bardales, S.; Tomara, G.; Ryu, J. H.; Kwon, I. C.; Goyal, G.; Ingber, D.; Shih, W.
10.1101/2023.12.29.573647 — immunology — Posted on 2025-04-04
4522 How drought and ploidy level shape gene expression and DNA methylation in Phragmites australis
Kuprina, K.; Haldan, K.; Saenko, S.; Gulam, M. S.; Kreyling, J.; Schnittler, M.; Bog, M.
10.1101/2025.03.31.646440 — ecology — Posted on 2025-04-04
4523 Topoisomerase IIα orchestrates secretion of IL-6 and IL-8 with human papillomavirus replication
Liu, Y.; Han, Z.; Kaminski, P.; Tao, C.; Li, X.; Liu, M.; Li, Y.; Jia, Y.; Xu, J.; Hong, S.
10.1101/2025.04.03.647014 — microbiology — Posted on 2025-04-04
4524 Rheinheimera palamurensis sp. a novel bacterium isolated from drinking water resources
Paul, T. R.; Shiva Shanker, A.; Kumar, D. K. S.; Srinivasulu, D.; Vootla, P. K.; Pindi, P. K.
10.1101/2025.04.03.647078 — microbiology — Posted on 2025-04-04
4525 Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers
Sadeqi, F.; Dong, D.; Stroh, K.; Vache, M.; Metz, J.; Riedel, D.; Janshoff, A.; Risselada, H. J.; Kolenda, C.; Meinecke, M.
10.1101/2025.04.03.647039 — biochemistry — Posted on 2025-04-04
4526 Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation
Eisner, V. R.; Lagos, D.; de Santiago, P. R.; Perez, N.; Cartes-Saavedra, B.; Vial-Brizzi, J.; Podmanicky, O.; Horvath, R.
10.1101/2025.04.03.647131 — cell biology — Posted on 2025-04-04
4529 Field potential Imaging in human iPSC- derived Cardiomyocytes using UHD-CMOS-MEA
Matsuda, N.; Nagafuku, N.; Matsuda, K.; Ishibashi, Y.; Taniguchi, T.; Matsushita, Y.; Miyamoto, N.; Yoshinaga, T.; Suzuki, I.
10.1101/2025.03.31.646249 — pharmacology and toxicology — Posted on 2025-04-04
4530 Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods
Forjaz, A.; Kramer, D.; Shen, Y.; Bea, H.; Tsapatsis, M.; Ping, J.; Queiroga, V.; Han, K. S.; Joshi, S.; Grubel, C.; Beery, M. L.; Kusmartseva, I.; Atkinson, M. A.; Kiemen, A. L.; Wirtz, D.
10.1101/2025.03.31.646356 — bioinformatics — Posted on 2025-04-04
4531 Embolization-on-a-chip: Novel Vascularized Liver Tumor Model for Evaluation of Cellular and Cytokine Response to Embolic Agents
Nguyen, H. T.; Tirpakova, Z.; Peirsman, A.; Maity, S.; Falcone, N.; Kawakita, S.; Khorsandi, D.; Rashad, A.; Farhadi, N.; Mandal, K.; Ermis, M.; Herculano, R. D.; Najafabadi, A. H.; Dokmeci, M. R.; Barros, N. R. D.; Khademhosseini, A.; Jucaud, V.
10.1101/2025.03.30.646225 — bioengineering — Posted on 2025-04-04
4532 A non-canonical cGAS-STING pathway drives cellular and organismal aging
Cancado de Faria, R.; Silva, L.; Teodoro-Castro, B.; McCommis, K. S.; Shashkova, E. V.; Gonzalo, S.
10.1101/2025.04.03.645994 — cell biology — Posted on 2025-04-04
4534 The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells
Amer, T.; Haimovici, A.; Kirschnek, S.; Vier, J.; Moeed, A.; Ukachukwu, U.; Helmstaedter, M.; Kayser, S.; Oellinger, R.; Rad, R.; Weber, A.; Badr, M. T.; Haecker, G.
10.1101/2025.04.03.646995 — cell biology — Posted on 2025-04-04
4536 Non-canonical HIPPO-MST1/2 promotes hyper-proliferation of pulmonary vascular cells through CDC20
Dey, T.; Zhyvylo, I.; Jiang, L.; Olapoju, S. O.; Pena, A.; Avolio, T.; Lin, D.; Goncharov, D.; Greenland, J. R.; Wolters, P. J.; DeLisser, H.; Pullamsetti, S. S.; Kudryashova, T. V.; Goncharova, E. A.
10.1101/2025.04.03.646845 — cell biology — Posted on 2025-04-04
4538 CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity
de Haan, L.; Dijt, S.; Lopez, A. G.; Ruan, D.; Bakker, F.; Everts, M.; Warner, H.; Mol, F. N.; de Boer, R.; Huis in 't Veld, P.; van de Kooij, B.; Vlijm, R.; van Vugt, M.
10.1101/2025.04.03.647079 — cell biology — Posted on 2025-04-04
4539 Gangliosides Modulate the Secretion of Extracellular Vesicles and Their Misfolded Protein Cargo
Monyror, J.; Kadam, V.; Morales, L. C.; Ordonez, D.; Ibanga, J.; Zaidi, A.; McNamara, E.; Pink, D.; Stenlund, M.; Reyes, K.; Maguire, A. D.; Huang, J.; Cortez, L. M.; Sim, V.; Mok, S.-A.; Posse de Chaves, E.; Sipione, S.
10.1101/2025.04.03.647108 — cell biology — Posted on 2025-04-04
4543 A statistical framework for inferring genetic requirements from embryo-scale single-cell sequencing experiments
Duran, M.; Barkan, E. R.; Tresenrider, A.; Lee, H.; Friedman, R. Z.; Lammers, N.; Colon, M.; Franks, J.; Ewing, B.; Kimelman, D.; Trapnell, C.
10.1101/2025.04.03.646654 — bioinformatics — Posted on 2025-04-04
4544 HyDrop v2: Scalable atlas construction for training sequence-to-function models
Dickmanken, H.; Wojno, M.; Theunis, K.; Eksi, E. C.; Mahieu, L.; Christiaens, V.; Kempynck, N.; De Rop, F. V.; Roels, N.; Spanier, K. I.; Vandepoel, R.; Hulselmans, G. J.; Poovathingal, S.; Aerts, S.
10.1101/2025.04.02.646792 — bioinformatics — Posted on 2025-04-04
4551 Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis
Shapira, Y.; Noack, F.; Vangelisti, S.; Chong, F.; Lifshitz, A.; Tanay, A.; Bonev, B.
10.1101/2025.04.03.647013 — genomics — Posted on 2025-04-04
4553 Genetic structure of sugar kelp in the St. Lawrence Estuary and Gulf (Quebec, Canada)
Treillefort, M.; Le Cam, S.; Valero, M.; Mauger, S.; Ruggieri, P.; Salvo, F.; Gendron-Lemieux, I.; Provencher, T.; Belley, R.; Dufresne, F.
10.1101/2025.04.01.646547 — evolutionary biology — Posted on 2025-04-04
4555 Embryo-scale single-cell chemical transcriptomics reveals dependencies between cell types and signaling pathways
Barkan, E.; Duran, M.; Lammers, N.; Tresenrider, A.; Jackson, D.; Lee, H.; Haagen, B.; Saunders, L.; Abitua, P.; Kimelman, D.; Trapnell, C.
10.1101/2025.04.03.646423 — developmental biology — Posted on 2025-04-03
4556 Novel multi-transmitter calyx-like giant synapse revealed in the extended amygdala
Zhang, L.; Hernandez, V.; Giraldo, D. M.; Leon-Contreras, J. C.; Ye, R.; Zhang, S.; Schafer, M. K.-H.; barrio, r.; Hernandez-Pando, R.; Ferraguti, F.; Eiden, L. E.
10.1101/2025.04.03.647119 — neuroscience — Posted on 2025-04-04
4559 Deciphering complex interactions between LTR retrotransposons and three Papaver species using LTR_Stream
Xu, T.; Bush, S. J.; Che, Y.; Zhao, H.; Wang, T.; Jia, P.; Wang, S.; Sun, P.; Zhang, P.; Gao, S.; Xu, Y.; Wang, C.; Dang, N.; Zhang, Y.; Yang, X.; Ye, K.
10.1101/2025.03.30.646164 — bioinformatics — Posted on 2025-04-03
4562 What are the best practices for curating eDNA custom barcode reference libraries? A case study using Australian subterranean fauna.
Guzik, M.; Stringer, D.; Thornhill, J.; Coates, P. J.; van der Heyde, M.; Hillyer, M.; White, N. E.; Sacco, M.; Beasley-Hall, P. G.; Humphreys, W. F.; Harvey, M. S.; Huey, J. A.; Wilson, N. G.; Alexander, J.; Humphreys, G.; King, R. A.; Cooper, S. J. B.; Pinder, A.; Perina, G.; Hosie, A. M.; Kirkendale, L.; Nevill, P.; Austin, A.
10.1101/2024.09.18.611555 — evolutionary biology — Posted on 2025-04-03
4565 An Experimental and Multiphysics Simulations Study of Clostridium carboxidivorans sp. 624 for Acid and Alcohol Production in CO2/H2
Tiong, Y. W.; Yong, A.; Nalaparaju, A.; Nguyen, H.-H.; Koh, L. Q.; Wong, R. J.; Lim, R. T. Y.; Ow, D. S.-W.; Zhang, J.; Nguyen, V. B.; Wong, F. T.; Lim, Y. H.
10.1101/2025.02.24.639814 — microbiology — Posted on 2025-04-03
4566 Serotonin modulation of metabolism and stress response in Pseudomonas fluorescens
Waclawikova, B.; Schwalbe, M.; Ilyaskina, D.; Toptas, S.; Thome, N. U.; Elsayed, S. S.; de Jong, A.; van Wezel, G. P.; El Aidy, S.
10.1101/2025.04.03.646968 — microbiology — Posted on 2025-04-03
4567 Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding
Wagner, B. C.; Geibel, C.; Stadelmann, A.; Rapp, J.; Link, H.; Nussbaum, E.; Grenzendorfer, H.-P.; Albrecht, R.; Hartmann, M. D.; Forchhammer, K.; Selim, K. A.; Hughes, C. C.; Petras, D.
10.1101/2025.04.03.647050 — microbiology — Posted on 2025-04-03
4570 Nucleus accumbens dopamine encodes the trace period during appetitive Pavlovian conditioning
Wanat, M. J.; Garcia-Castaneda, B. I.; Alducin-Martinez, C.; Cedillo, L. G.; Camacho, E. T.; Phillips, P. E. M.
10.1101/2025.01.07.631806 — neuroscience — Posted on 2025-04-03
4571 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma
Saha, S.; Zhang, Y.; Gibert, M. K.; Dube, C.; Hanif, F.; Mulcahy, E.; Bednarek, S.; Marcinkiewicz, P.; Wang, X.; Kwak, G.; Hudson, K.; Sun, Y.; Dinda, M.; Saha, T.; Guessous, F.; Cruickshanks, N.; Colon, R. R.; Dell'Olio, L. G.; Anbu, R.; Kefas, B.; Kumar, P.; Klibanov, A. L.; Schiff, D.; Suk, J. S.; Hanes, J.; Mata, J.; Hafner, M.; Abounader, R.
10.1101/2025.04.01.646663 — cancer biology — Posted on 2025-04-03
4572 Pathogenicity Patterns in Cytochrome P450 Family
Spackova, A.; Kadasova, N.; Varekova, I. H.; Berka, K.
10.1101/2025.03.30.646180 — bioinformatics — Posted on 2025-04-03
4574 Pooled scanning of protein variants identifies novel RNA-binding mutants
Tasca, J. A.; Doherty, J. F.; Shields, E. J.; Dissanayaka Mudiyanselage, S.; Reich, L. N.; Sarma, K.; Garcia, B.; Bonasio, R.
10.1101/2025.04.02.646914 — biochemistry — Posted on 2025-04-03
4576 Acquired Amphotericin B Resistance Attributed to a Mutated ERG3 in Candidozyma auris
Massic, L. K.; Doorley, L. A.; Jones, S. J.; Richardson, I.; Siao, D. D.; Siao, L.; Dykema, P.; Hua, C. N.; Schneider, E.; Cuomo, C. A.; Rogers, P. D.; Van Hooser, S.; Parker, J.; Kelly, S. L.; Hess, D.; Rybak, J. M.; Pandori, M. W.
10.1101/2025.03.30.646105 — genetics — Posted on 2025-04-03
4578 Structural basis of a phosphotransferase system xylose transporter
Takahashi, Y. S.; Kohga, H.; Chek, M. F.; Yamamoto, K.; Takahashi, J. F.; Shigematsu, H.; Tanaka, Y.; Ichikawa, M.; Miyazaki, R.; Hakoshima, T.; Tsukazaki, T.
10.1101/2025.04.02.646771 — molecular biology — Posted on 2025-04-03
4582 Immune-parenchymal multicellular niches are shared across distinct thyroid autoimmune diseases
Rengarajan, M.; Normand, R.; Tran, H.; Nieman, L. T.; Arnold, B.; Calcaterra, M.; Xu, K. H.; Richieri, P.; Rodriguez, E. E.; Slowikowski, K.; Song, Y.; Tirard, A.; Stephen, A. E.; Sadow, P. M.; Parangi, S.; Daniels, G. H.; Luster, A. D.; Villani, A.-C.
10.1101/2025.03.30.646176 — immunology — Posted on 2025-04-03
4585 Vascular niches are the primary hotspots for aging within the multicellular architecture of cardiac tissue
Rodriguez Morales, D.; Larcher, V.; Ruz Jurado, M.; Tombor, L.; Zanders, L.; Wagner, J. U. G.; Zeiher, A. M.; Kuppe, C.; John, D.; Schulz, M. H.; Dimmeler, S.
10.1101/2025.03.30.646237 — physiology — Posted on 2025-04-03
4586 Deciphering spatiotemporal patterns of rhizodeposition with a functional-structural root model: RhizoDep
Rees, F.; Gerault, T.; Gauthier, M.; Barillot, R.; Richard-Molard, C.; Jullien, A.; Chenu, C.; Pradal, C.; Andrieu, B.
10.1101/2025.03.30.646173 — physiology — Posted on 2025-04-03
4587 WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
Tjeerdsma, R. B.; Ng, T.; Roorda, M.; Bianchi, D.; Yang, S.; Bonnet, C.; VanInsberghe, M.; Everts, M.; Bakker, F.; de Boer, R.; Moatti, N.; Hustedt, N.; Yin, J.; Hoeg, L.; Leibovitch, M.; Sicheri, F.; van Oudenaarden, A.; de Jong, S.; van den Berg, J.; Tanenbaum, M. E.; Brummelkamp, T. R.; Durocher, D.; van Vugt, M.
10.1101/2025.03.12.642754 — cancer biology — Posted on 2025-04-03
4591 Effect of the S2' site cleavage on SARS-CoV-2 spike
Shi, W.; Jonaid, G.; Kibria, M. G.; Allen, J.; Peng, H.; Rits-Volloch, S.; Zhu, H.; Wang, S.; Walsh, R. M.; Lu, J.; Chen, B.
10.1101/2025.04.02.646838 — biochemistry — Posted on 2025-04-03
4593 A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese Quartet
Wang, B.; Jia, P.; Bush, S. J.; Wang, X.; Yang, Y.; Zhang, Y.; Wan, S.; Yang, X.; Zhang, P.; Zheng, Y.; Shi, L.; Dong, L.; Ye, K.
10.1101/2025.03.30.646227 — genomics — Posted on 2025-04-03
4594 Causal inference for multiple risk factors and diseases from genomics data
Machnik, N.; Mahmoudi, M.; Borczyk, M.; Kraetschmer, I.; Bauer, M. J.; Robinson, M. R.
10.1101/2023.12.06.570392 — genetics — Posted on 2025-04-03
4596 BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM
Hanna, M. G.; Rodriguez Cruz, H. O.; Fujise, K.; Wu, Y.; Xu, C. S.; Pang, S.; Zhuoning, L.; Monetti, M.; De Camilli, P.
10.1101/2024.09.28.615015 — cell biology — Posted on 2025-04-03
4600 Genomic epidemiology reveals antibiotic resistance transfer and polyclonal dissemination of Acinetobacter baumannii in a Paraguayan hospital
Bello-Lopez, E.; Kawabata, A.; Cantero, J.; Mendoza, S.; Pertile, E.; Perez-Osegura, A.; Cevallos, M. A.; Peralta, H.; Aguilar-Vera, A.; Castillo-Ramirez, S.
10.1101/2025.04.03.647102 — microbiology — Posted on 2025-04-03
4601 High-content assessment of Pseudomonas aeruginosa bacteriophage efficacy reveals host genetic factors involved in phage specificity
Ellward, G. L.; Bucher, M. J.; Zhai, Y.; Munguia, N. S.; Marini, S.; Marsella, R.; Bisesi, J. H.; Montazeri, N.; Cherabuddi, K.; Jeong, K. C.; Czyz, D. M.
10.1101/2025.04.03.646983 — microbiology — Posted on 2025-04-03
4603 Establishing an ex vivo porcine skin model to investigate the effects of broad spectrum antiseptic on viable skin microbial communities
Townsend, E. C.; Xu, K.; De La Cruz, K.; Huang, L.; Sandstrom, S.; Meudt, J.; Shanmuganayagam, D.; Huttenlocher, A.; Gibson, A. L. F.; Kalan, L.
10.1101/2025.04.03.647100 — microbiology — Posted on 2025-04-03
4604 Minimal impact of ivermectin on immune response and transcriptional profiles in naïve adults with mild COVID-19
Ribes, M.; Torres, C.; Canyelles, M.; Rubio, R.; Vidal, M.; Izquierdo, L.; Blanco-Di Matteo, A.; Pineda, I.; Fernandez-Montero, A.; Jordan-Iborra, C.; Carmona-Torre, F.; Yuste, J. R.; Del Pozo, J. L.; Reina, G.; Sadaba, B.; Fernandez-Alonso, M.; Santamaria, P.; Carolis, C.; Aguilar, R.; Macia, D.; Chaccour, C.; Dobano, C.; Moncunill, G.
10.1101/2025.03.31.646276 — immunology — Posted on 2025-04-03
4607 Insights into the bioluminescence systems of three sea pens (Cnidaria: Anthozoa): from de novo transcriptome analyses to biochemical assays
Duchatelet, L.; Galeazzo, G. A.; Coubris, C.; Bridoux, L.; Rezsohazy, R.; Melo, M. R. S.; Marek, M.; Amaral, D. T.; Dupont, S.; Oliveira, A. G.; Delroisse, J.
10.1101/2024.04.30.591678 — zoology — Posted on 2025-04-03
4610 PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Secreted Proteins by Single Cells
Lussier, F.; Moon, B.-U.; Janta-Polczynski, M.; Morocz, Y.; Svahn, F.; Shen, M. L.; Lukic, L.; Malic, L.; Veres, T.; Ng, A.; Juncker, D.
10.1101/2025.03.26.645608 — bioengineering — Posted on 2025-04-03
4611 Development of pyrazolopyrimidine based macrocyclic kinase inhibitors targeting AAK1
Mensing, T. E.; Kurz, C. G.; Amrhein, J. A.; Ehret, T. A. L.; Preuss, F.; Mathea, S.; Karim, M.; Tran, D. H. N.; Kadlecova, Z.; Tolvanen, T.; Martinez-Molina, D.; Mueller, S.; Einav, S.; Knapp, S.; Hanke, T.
10.1101/2025.04.02.646796 — biochemistry — Posted on 2025-04-03
4612 High-resolution detection of copy number alterations in single cells with HiScanner
Zhao, Y.; Luquette, L. J.; Veit, A. D.; Wang, X.; Xi, R.; Viswanadham, V. V.; Zhang, Y.; Shao, D. D.; Walsh, C. A.; Yang, H. W.; Johnson, M. D.; Park, P. J.
10.1101/2024.04.26.587806 — genomics — Posted on 2025-04-03
4616 Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex
Shao, D. D.; Zhao, Y.; Brew, J.; Ghosh, U.; Luquette, L. J.; Zhao, S.; Kriz, A. J.; Qian, X.; Viswanadham, V. V.; Taketomi, T.; Tsuruta, F.; Park, P. J.; Walsh, C. A.
10.1101/2024.10.08.617159 — neuroscience — Posted on 2025-04-03
4617 ABERRANT NEURAL ADAPTATION TO EXPECTED UNCERTAINTY IN ADULTS WITH AUTISM SPECTRUM DISORDER
Pultsina, K.; Kozunova, G.; Chernyshev, B.; Prokofyev, A.; Tretyakova, V.; Novikov, A.; Rytikova, A.; Stroganova, T.
10.1101/2025.03.30.646160 — neuroscience — Posted on 2025-04-03
4618 Brainwide genetic capture for conscious state transitions
Lazaro, H.; Schneider, K. N.; Jin, M.; Beck, A.; Rijsketic, D. R.; Murry, A. D.; Navarrete, J.; Shin, C. C.; Barrow, A. C.; Campuzano, I.; Nota, M. H.; Ressler, N.; Apley, E.; Zhang, J.; Gutierrez, G.; Szelenyi, E. R.; Nilsson, S. R.; Denny, C. A.; Bruchas, M. R.; Heifets, B. D.; de la Iglesia, H. O.; Golden, S. A.; Heshmati, M.
10.1101/2025.03.28.646066 — neuroscience — Posted on 2025-04-03
4620 DNA Specimen Preservation using DESS and DNA Extraction in Museum Collections: A Case Study Report
Ogiso-Tanaka, E.; Shimada, D.; Ogawa, A.; Ishiyama, G.; Okumura, K.-i.; Hosaka, K.; Ishii, C.; Nam, K. O.; Hoshino, M.; Nomura, S.; Kakizoe, S.; Nakamura, Y.; Nishiumi, I.; Ito, M. A.; Kitayama, T.; Tanaka, N.; Hosoya, T.; Jinbo, U.
10.1101/2025.03.30.646169 — zoology — Posted on 2025-04-03
4622 Cationic amino acid identity and net charge influence condensate properties in E. coli
Kidane, A. K.; Rosenfeld, J. R.; Johnston, J. D.; Dubbeldam, C.; Paraan, M.; Obermeyer, A. C.
10.1101/2025.03.29.646054 — biophysics — Posted on 2025-04-03
4628 Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau
Santambrogio, A.; Lovestam, S.; Metrick, M. A.; Lohr, T. S.; Xu, P.; Caughey, B.; Scheres, S.; Vendruscolo, M.
10.1101/2025.03.29.646137 — neuroscience — Posted on 2025-04-03
4629 Using an ODE model to separate Rest and Task signals in fMRI
Kashyap, A.; Geenjaar, E. P. T.; Bey, P.; Dhindsa, J.; Glomb, K.; Plis, S.; Keilholz, S.; Ritter, P.
10.1101/2023.10.23.563564 — neuroscience — Posted on 2025-04-03
4631 Long-term memory reorganization of navigational episodes
Iggena, D.; Schmelter, T.; Maier, P. M.; Requieg, K.; Finke, C.; Hildebrand, K.; Ploner, C. J.
10.1101/2025.04.01.646566 — neuroscience — Posted on 2025-04-03
4635 TRUHiC: A TRansformer-embedded U-2 Net to enhance Hi-C data for 3D chromatin structure characterization
Li, C.; Mowlaei, M. E.; Human Genome Structural Variation Consortium, ; HGSVC Functional Analysis Working Group, ; Carnevale, V.; Kumar, S.; Shi, X.
10.1101/2025.03.29.646133 — bioinformatics — Posted on 2025-04-03
4636 Advancing EEG Biosensing: Novel Scalable Production of Platinum-Silicon Microneedles
Amir, M.; Ding, R.; Rusli, N. I.; Vercooren, N.; Ceyssens, F.; Kuznetsova, N.; Bertrand, A.; Kraft, M.; Taurino, I.
10.1101/2025.03.29.646121 — bioengineering — Posted on 2025-04-03
4638 SMAdd-seq: Probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing
Bai, G.; Dhillon, N.; Felton, C. A.; Meissner, B.; Saint-John, B.; Shelansky, R.; Meyerson, E.; Hrabeta-Robinson, E.; Hodjat, B.; Boeger, H.; Brooks, A. N.
10.1101/2024.03.20.585815 — genomics — Posted on 2025-04-03
4639 MarpolBase: Genome database for Marchantia polymorpha featuring high quality reference genome sequences
Tanizawa, Y.; Mochizuki, T.; Yagura, M.; Sakamoto, M.; Fujisawa, T.; Kawamura, S.; Shimokawa, E.; Yamaoka, S.; Nishihama, R.; Bowman, J. L.; Berger, F.; Yamato, K.; Kohchi, T.; Nakamura, Y.
10.1101/2025.03.30.646155 — genomics — Posted on 2025-04-03
4641 The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis
Kubra, S.; Sun, M.; Dion, W.; Catak, A.; Luong, H.; Wang, H.; Pan, Y.; Liu, J.-J.; Ponna, A.; Sipula, I.; Jurczak, M. J.; Liu, S.; Zhu, B.
10.1101/2024.09.13.612812 — cell biology — Posted on 2025-04-03
4644 Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo
Schnitzerlein, M.; Greto, E.; Wegner, A.; Möller, A.; Aust, O.; Ben Brahim, O.; Uderhardt, S.; Zaburdaev, V.
10.1101/2024.01.24.577158 — immunology — Posted on 2025-04-03
4646 Derepression of transposable elements in mouse prefrontal cortex disrupts social behavior
Kim, R. K.; Smith, C.; Truby, N. L.; Carwile, N.; Silva, G. M.; Neve, R. L.; Cui, X.; Hamilton, P. J.
10.1101/2025.03.31.646358 — neuroscience — Posted on 2025-04-03
4647 Metabolic Alteration in Oxylipins and Endocannabinoids Point to an Important Role for Soluble Epoxide Hydrolase and Inflammation in Alzheimer's Disease - Finding from Alzheimer's Disease Neuroimaging Initiative.
Borkowski, K.; Yin, C.; Kindt, A.; Liang, N.; de Lange, E. C. M.; Blach, C.; Newman, J.; Kaddurah-Daouk, R.; Hankemeier, T.; Alzheimer's Disease Metabolomics Consortium, ; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2025.04.01.646677 — neuroscience — Posted on 2025-04-03
4649 Novel dopaminergic neurotransmission in the Octopus visual system
Courtney, A.; Styfhals, R.; Van Dijck, M.; Boulanger, J.; Geenen, L.; Lanoizelet, M.; Hardege, I.; Lassnig, M.; Jansson, A. M.; Gehler-Rahman, J.; Almansa, E.; Obenhaus, H.; Seuntjens, E.; Schafer, W. R.
10.1101/2025.04.02.646353 — neuroscience — Posted on 2025-04-03
4650 Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases
Bubeck, M.; Penkert, K. A.; Limberger, H.; Gonzalez Acera, M.; Plattner, C.; Ziegler, S.; Muppirala, A. N.; Forster, P.; Jakob, M.; Gamez-Belmonte, R.; Erkert, L.; Kulkarni, S.; Guenther, C.; Atreya, R.; Kuehl, A. A.; Hegazy, A.; Hildner, K.; Trajanoski, Z.; Siegmund, B.; Neurath, M. F.; IBDome Consortium, ; Rao, M.; Progatzky, F. a.; Lie, D. C.; Becker, C.; Romagnani, C.; Ludwig, L. S.; Klose, C. S. N.; Patankar, J. V.
10.1101/2025.04.03.646820 — neuroscience — Posted on 2025-04-03
4651 Real-time spike sorting with 3D neural probe and triangulation localization
Yang, A.-C.; Zhang, J.-H.; Chen, K.-P.; Kao, K. H.; Lee, W.-J.; McLaughlin, M.; Chen, N.-Y.; Sun, J.-J.
10.1101/2025.03.30.645752 — neuroscience — Posted on 2025-04-03
4655 Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution
Zanders, L.; Glaser, S.-F.; Ruz Jurado, M.; Brandt, M. .; John, D.; Nicin, L.; Rodriguez Morales, D.; Abplanalp, W. T.; Procida-Kowalski, T.; Ganss, F.; Ullrich, E.; Debes, A.; Pennoyer, P.; Bartkuhn, M.; Dettmeyer, R. B.; Zeiher, A. M.; Nagel, E.; Wenzel, P.; Dimmeler, S.
10.1101/2025.04.02.646923 — cell biology — Posted on 2025-04-03
4657 Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice
Klaile, E.; Müller, M. M.; Sonnberger, J.; Bothe, A.-K.; Brehme, S.; Ehrenpfordt, J.; Klassert, T.; Kuhn, S.; Dietert, K.; Kershaw, O.; Praetorius, J.-P.; Figge, M. T.; Bauer, T.; Gebhardt, A.; Mall, G.; Jacobsen, I. D.; Slevogt, H.
10.1101/2025.03.29.646107 — immunology — Posted on 2025-04-03
4658 An in vivo CRISPR screen unveils top target genes to efficiently improve CAR-T cell persistence in a solid tumour model of lung adenocarcinoma
Fumagalli, M.; An, D.; Simula, L.; Combe, C.; Aziez, L.; Simoni, Y.; Alves-Guerra, M.-C.; Valentini, A.; Marchais, M.; Vermare, A.; Bercovici, N.; Donnadieu, E.; Pendino, F.
10.1101/2025.03.28.645780 — immunology — Posted on 2025-04-03
4659 Light Impact on Thalamo-Cortical Connectivity During an Executive Cognitive Task: Effects of Time of Day and Specificities of Teenagers
Sharifpour, R.; Campbell, I.; Paparella, I.; Balda, F.; Beckers, E.; Mortazavi, N.; Koshmanova, E.; Read, J.; Collette, F.; Phillips, C.; Talwar, P.; Lamalle, L.; Zubkov, M.; Vandewalle, G.
10.1101/2025.04.03.647005 — neuroscience — Posted on 2025-04-03
4660 Optical recordings of synaptic vesicle fusion reveal diffusional dispersion
Klingauf, J.; Glyvuk, N.; Duan, J.; Krishnan, S.; Tsytsyura, Y.; Keller, U.; Sunil, L. P.; Nosov, G.; Hueve, J.; Selenschik, P.; Reissner, C.; Missler, M.; Kahms, M.
10.1101/2025.03.31.646326 — neuroscience — Posted on 2025-04-03
4661 Dynamics of thalamic directional coding under vestibular imbalance
El Mahmoudi, N.; Huret, A.; Laurent, C.; Laurens, J.; Jacob, P.-Y.; Sargolini, F.
10.1101/2025.03.31.646416 — neuroscience — Posted on 2025-04-03
4663 Ion Dynamics Underlying the Seizure Delay Effect of Low-Frequency Electrical Stimulation
Girier, G.; Dallmer-Zerbe, I.; Chvojka, J.; Kudlacek, J.; Jiruska, P.; Hlinka, J.; Schmidt, H.
10.1101/2025.04.01.646594 — neuroscience — Posted on 2025-04-03
4667 Object categorization based on abstract concepts by monkeys, humans, and vision models
Zhang, H.; Zheng, Z.; Hu, J.; Wang, Q.; Xu, M.; Zhou, Z.; Li, Z.; Okazawa, G.
10.1101/2025.04.02.646407 — neuroscience — Posted on 2025-04-03
4668 New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer's Disease
Hu, M.; Esmaeeli, S.; Stolzenburg, L.; Jouni, M.; Nyamugenda, E.; Reinhardt, P.; Bahnassawy, L.; Gasparini, L.; Waring, J. F.; Vasanthakumar, A.
10.1101/2025.03.31.646439 — neuroscience — Posted on 2025-04-03
4669 Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke
Desilles, J.-P.; compoCLOT study group, ; Solo Nomenjanahary, M.; Perrot, A.; Di Meglio, L.; Zemali, F.; ZALGHOUT, S.; Loyau, S. S.; Labreuche, J.; Bourrienne, M.-C.; Faille, D.; Delvoye, F.; Ollivier, V.; Dupont, S.; ROGOZARSKI, J.; Brikci-Nigassa, N.; Ajzenberg, N.; Mazighi, M.; Ho-Tin-Noe, B.
10.1101/2025.03.28.646062 — pathology — Posted on 2025-04-03
4670 Zinc stimulation of phytoplankton in a low carbon dioxide, coastal Antarctic environment: evidence for the Zn hypothesis
Kell, R. M.; Subhas, A. V.; Schanke, N. L.; Lees, L. E.; Chmiel, R. J.; Rao, D.; Brisbin, M. M. M.; Moran, D. M.; McIlvin, M. R.; Bolinesi, F.; Mangoni, O.; Casotti, R.; Balestra, C.; Horner, T.; Dunbar, R. B.; Allen, A. E.; DiTullio, G. R.; Saito, M. A.
10.1101/2023.11.05.565706 — biochemistry — Posted on 2025-04-03
4671 Sex-biased computations underlying differential set shift performance in mice
Glewwe, N.; Dastin-van Rijn, E. M.; Chen, C. S.; Giglio, E.; Knep, E.; Ebitz, R. B.; Widge, A. S.; Grissom, N. M.
10.1101/2025.04.01.646712 — animal behavior and cognition — Posted on 2025-04-03
4672 Advancing ecological assessment: The integration of eDNA metabarcoding into an estuarine fish index
Bhendarkar, M.; Canals, O.; Jurado, C.; Mendibil, I.; Uriarte, A.; Borja, A.; Rodriguez-Ezpeleta, N.
10.1101/2025.03.31.645977 — ecology — Posted on 2025-04-03
4674 Immune surveillance and pruning of neuronal stem cells in the medaka retina
Agarwal, R.; Benjaminsen, J.; Lust, K.; Becker, C.; Fuchs, N.; Hasel de Carvalho, E.; Eggeler, F.; El Said Ibrahim, O.; Aghaallaei, N.; Bajoghli, B.; Wittbrodt, J.
10.1101/2025.04.01.646524 — developmental biology — Posted on 2025-04-03
4675 An intercellular metabolic relay for brain sparingin Drosophila
Franchet, A.; Jin, Y.; Newell, C. L.; Girard, V.; Maniere, G.; Grosjean, Y.; Barrington, C.; MacRae, J. I.; Gilmore, I. S.; Gould, A. P.
10.1101/2025.04.02.645514 — developmental biology — Posted on 2025-04-03
4677 Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle
Maya-Miles, D.; Garcia-Martinez, J.; Cases, I.; Pasion, R.; de la Cruz, J.; Perez-Ortin, J. E.; Munoz-Centeno, M. d. l. C.; Chavez, S.
10.1101/2025.01.05.631386 — molecular biology — Posted on 2025-04-03
4680 Tonotopic Specialization of MYO7A Isoforms in Auditory Hair Cells
Li, S.; Park, J.; Phan, T. M.; Egelman, E. H.; Bird, J. E.; Shin, J.-B.
10.1101/2025.04.01.646665 — neuroscience — Posted on 2025-04-03
4681 Anisotropic light propagation in human brain white matter
Pini, E.; Di Meo, D.; Costantini, I.; Sorelli, M.; Bradley, S.; Wiersma, D. S.; Pavone, F. S.; Pattelli, L.
10.1101/2025.04.02.646745 — neuroscience — Posted on 2025-04-03
4683 Pumping Up your Predictive Power for Cognitive State Detection with the Proper GAINS
Rodrigues, V. R.; Prieto, J. R.; Beres, S. L.; Stephens, C. L.; Myers, C.; Napoli, N. J.
10.1101/2025.04.01.646685 — neuroscience — Posted on 2025-04-03
4685 Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
Taylor, C. J. L.; Renstrom, J. G.; Loayza, J.; Gwilt, M.; Williams, S. A.; Grasmeder Allen, R.; Moran, P. M.; Gigg, J.; Neill, J.; Harte, M.; Bast, T.
10.1101/2025.04.01.646403 — neuroscience — Posted on 2025-04-03
4687 Multi-modal Monte Carlo MRI simulator of tissue microstructure
Cottaar, M.; Zheng, Z.; Miller, K.; Tendler, B. C.; Jbabdi, S.
10.1101/2025.04.03.646577 — neuroscience — Posted on 2025-04-03
4689 Localization of AP2α2, TRPV1 and PIEZO2 to the Large Dense Core Vesicles of Human Dorsal Root Ganglion Neurons
Joshi, O.; Cooper, A.; Powell, R.; Martin, M. K.; Rodriguez, R.; Kuechle, J. B.; Bhattacharjee, A.
10.1101/2025.03.31.646357 — neuroscience — Posted on 2025-04-03
4693 Development of Replay-DMN Coordination Predicts Entorhinal Grid Codes
Pang, L.; Qu, Y.; Ou, J.; Wu, S.; Luo, Y.; Gohil, C.; Woolrich, M.; Behrens, T.; Liu, Y.
10.1101/2025.04.02.646732 — neuroscience — Posted on 2025-04-03
4694 Glycolysis-enhancing alpha 1-adrenergic antagonists are neuroprotective in Alzheimers disease
Zhang, Q.; Schultz, J.; Simmering, J.; Kirkpatrick, B. Q.; Weber, M. A.; Skuodas, S.; Hicks, T.; Pierce, G.; Laughlin, M.; Bertolli, A. X.; Larson, T.; Thangavel, R.; Oya, M.; Meyerholz, D.; Aldridge, G.; Fassler, J.; Narayanan, N. S.
10.1101/2025.04.03.647018 — neuroscience — Posted on 2025-04-03
4703 Canonical Wnt/β-catenin signalling regulates inducible aging and regeneration loss in hydra
Tökölyi, J.; Kumagai, Y.; Szilagyi, R. K.; Nagy, N. A.; Szakal, V.; Daryono, R. N. H.
10.1101/2025.04.01.646560 — developmental biology — Posted on 2025-04-03
4704 Optimizing Protocols for MicroRNA Profiling of Infant and Toddler Stool
Armstrong, D. A.; Soucy, S. M.; Muse, M. E.; Kolling, F. W.; Trask, H. W.; Howell, A. L.; Laue, H. E.; Hoen, A.; Gui, J.; Christensen, B.; Madan, J. C.; Karagas, M. R.; Howe, C. G.
10.1101/2025.04.01.646630 — developmental biology — Posted on 2025-04-03
4705 DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm
Preza, S.; Zheng, B.; Liu, M.; Gao, Z.; Alvarez-Dominguez, J. R.; Biju, A.
10.1101/2025.04.03.647023 — developmental biology — Posted on 2025-04-03
4706 Nanosecond pulsed electric field precisely manipulates cytoplasmic Ca2+ oscillations during oocyte activation
Lu, Q.; Sun, Y.; An, T.; Liang, R.; Luo, Y.; Xia, H.; Fu, L.; Han, S.; Zhu, Y.; Song, Z.; Bai, X.; Fu, Y.; Fu, X.; Hou, Y.
10.1101/2025.04.03.646992 — developmental biology — Posted on 2025-04-03
4708 Intestinal control of feeding initiation in Drosophila melanogaster
Reinger, C.; Blackie, L.; Gillet, H.; Gaspar, P.; Medeiros, A. M.; Hadjieconomou, D.; Sickmann, M.; Affolter, M.; Miguel-Aliaga, I.; Kempf, A.; Müller, M.
10.1101/2025.03.31.646269 — developmental biology — Posted on 2025-04-03
4709 Behavioral Efficacy of AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 Syndrome
Torturo, C. L.; Du, A.; Kerker, K.; Gresack, J.; DeGrave, C.; Funk, K.; Agnihotri, P.; Hsieh, F.; Gunn, T. M.; Ramboz, S.; Bettencourt, B.; Reich, S.; Gao, G.; Wang, D.; Sah, D. W. Y.
10.1101/2025.04.02.646887 — neuroscience — Posted on 2025-04-03
4713 Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling
Thomazeau, A.; Rannio, S.; Brock, J. A.; Wong, H. H.-W.; Sjöström, P. J.
10.1101/2025.02.07.637179 — neuroscience — Posted on 2025-04-03
4721 Zebrafish armc9 mutant reveals a link between ARM-Type fold domain loss, inflammation, and spinal curvature
Rubilar-Fajardo, A.; Munoz-Montecinos, C.; Esperguel-Toledo, G.; Carrasco, S.; Castro, A.; Alvarado, P.; Kugath, A.; Araya-Secchi, R.; Allende, M.; Marcellini, S.; Gonzalez-Ortiz, M.; Roman, J.; Boltana, S.; Aguilera, F.; Cooper, T.; Cooper, J.; Cheng, K.; Mullins, M. C.; Caprile, T.; Fuentes, R.
10.1101/2025.04.02.646874 — developmental biology — Posted on 2025-04-03
4723 Goblet cells mechanically breach the epithelial barrier in gut homeostasis
Creff, J.; He, Y.; Bernat-Fabre, S.; Buscail, E.; Neuvendel, S.; Krishnakumar, V.; Mangeat, T.; Xue, S.-L.; Krndija, D.
10.1101/2025.04.01.646617 — cell biology — Posted on 2025-04-03
4724 Linear ubiquitination triggers Amph-mediated T-tubule biogenesis
Kawaguchi, K.; Hama, Y.; Yoshikawa, H.; Nishino, K.; Morimoto, K.; Nakamura, T.; Koizumi, M.; Sakamaki, Y.; Abe, K.; Kakuta, S.; Ichimura, K.; Ikeda, F.; Kosako, H.; Fujita, N.
10.1101/2025.04.03.646909 — cell biology — Posted on 2025-04-03
4725 A novel reporter to visualize and quantify endogenous inflammasomes and caspase-1 recruitment
Gohr, F. N.; Christensen, M. H.; Jenster, L.-M.; Tesfamariam, Y. M.; Lapp, D. J.; Mackenzie, J.; Schmidt, F. I.
10.1101/2025.03.30.646205 — immunology — Posted on 2025-04-03
4729 Neuroimaging Biomarkers of Neuroprotection: Impact of Voluntary versus Enforced Exercise in Alzheimers Disease Models
Badea, A.; Mahzarnia, A.; Reddy, D.; Dong, Z.; Anderson, R. J.; Moon, H. S.; Stout, J. A.; Williams, J.; Hirschler, L.; Barbier, E. L.; Williams, C. L.
10.1101/2025.03.28.646015 — neuroscience — Posted on 2025-04-03
4730 Data-driven classification of tissue water populations by massively multidimensional diffusion-relaxation correlation MRI
Narvaez, O.; Yon, M.; Salo, R. A.; Kyyriäinen, J.; Estela, M.; Paasonen, E.; Topgaard, D.; Sierra, A.
10.1101/2025.03.28.645938 — neuroscience — Posted on 2025-04-03
4732 Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability
Garcia, J. D.; Wang, C.; Alexander, R.; Banks, E.; Fenton, T.; DeKeyser, J.-M.; Abramova, T. V.; George, A. L.; Ben-Shalom, R.; Hackos, D. H.; Bender, K. J.
10.1101/2024.12.17.629038 — neuroscience — Posted on 2025-04-03
4733 Natural language processing of gene descriptions for overrepresentation analysis with GeneTEA
Boyle, I. A.; Aquib, N. A.; Kocak, M.; Creasi, R.; Montgomery, P. G.; Campbell, C. D.; Dempster, J. M.
10.1101/2025.03.28.646026 — bioinformatics — Posted on 2025-04-03
4735 Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature
Unitt, A.; Krisna, M. A.; Parfitt, K. M.; Jolley, K. A.; Maiden, M. C. J.; Harrison, O. B.
10.1101/2025.03.28.646058 — genomics — Posted on 2025-04-03
4737 Sleep rescues age-associated loss of glial engulfment
Zhang, J.; Brown, E. B.; Lloyd, E.; Farhy-Tselnicker, I.; Keene, A. C.
10.1101/2025.04.02.646667 — neuroscience — Posted on 2025-04-03
4739 Glucose levels are associated with mood, but the association is mediated by ratings of metabolic state
Kaduk, K.; Kaeber, M.; Kuehnel, A.; Berjano Torrado, M.; Grahlow, M.; Derntl, B.; Kroemer, N. B.
10.1101/2025.03.28.645871 — neuroscience — Posted on 2025-04-03
4741 T6SS-mediated competition by Stenotrophomonas rhizophila shapes seed-borne bacterial communities and seed-to-seedling transmission dynamics
Garin, T.; Brault, A.; Marais, C.; Briand, M.; Preveaux, A.; Bonneau, S.; Simonin, M.; Barret, M.; Sarniguet, A.
10.1101/2024.07.22.604635 — microbiology — Posted on 2025-04-03
4742 Transmembrane Serine Protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in lung squamous cell carcinoma
Sunil, H. S.; Clemenceau, J.; Barnfather, I.; Nakkireddy, S. R.; Grichuk, A.; Izzo, L. T.; Evers, B. M.; Thomas, L.; Subramaniyan, I.; Li, L.; Putnam, W. T.; Zhu, J.; Updegraff, B.; Minna, J. D.; DeBerardinis, R. J.; Gao, J.; Hwang, T. H.; Oliver, T. G.; O'Donnell, K. A.
10.1101/2025.04.01.646727 — cancer biology — Posted on 2025-04-03
4743 Deep Mutational Scanning Reveals EGFR Mutations Conferring Resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945
Wang, Y.; Hao, Y.; Ranieri, M.; Hollenberg, M.; Lopez, A.; Moore, X. T. R.; Sherman, F.; Deng, J.; Wong, K.-K.; Shum, E.; Poirier, J.
10.1101/2025.03.31.646429 — cancer biology — Posted on 2025-04-03
4744 Epitope Expression Persists in Circulating Tumor Cells as Breast Cancers Acquire Resistance to Antibody Drug Conjugates
Mishra, A.; Abelman, R.; Cunneely, Q.; Putaturo, V.; Deshpande, A. A.; Bell, R.; Seider, E. M.; Xu, K. H.; Shan, M.; Kelly, J.; Huang, S.-B.; Gopinathan, K. A.; Kikkeri, K.; Edd, J. F.; Walsh, J.; Dai, C. S.; Ellisen, L.; Ting, D. T.; Nieman, L.; Toner, M.; Bardia, A.; Haber, D. A.; Maheswaran, S.
10.1101/2025.04.02.646822 — cancer biology — Posted on 2025-04-03
4745 Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer
Turos, D.; Decollogny, M.; Chanfon, A.; Siffert, M.; Romanens, L.; Tille, J.-C.; Tredan, O.; Labidi-Galy, I.; Valdeolivas, A.; Rottenberg, S.
10.1101/2025.04.02.646768 — cancer biology — Posted on 2025-04-03
4748 Pregnancy-Dependent Cardioprotection via GPER Activation in Dahl Salt-Sensitive Rats
Alencar, A. K. N.; Swan, K. F.; Manoharan, M. M.; Natale, C. A.; Lindsey, S. H.; Pridjian, G.; Garrett, M. R.; Bayer, C. L.
10.1101/2025.04.01.646468 — pharmacology and toxicology — Posted on 2025-04-03
4749 Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy
Serra-Mir, G.; Haro-Martiez, E.; Cannata, C.; Palomeque, J. A.; Blasco-Benito, S.; Lopez-Plana, A.; Sanz-Flores, M.; Sabartes, M.; Fornaguera, C.; Celia-Terrassa, T.
10.1101/2025.04.02.646434 — cancer biology — Posted on 2025-04-03
4750 Developing a zebrafish xenograft model of diffuse midline glioma
Wang, K.; Graziano, G.; Ceisel, A.; Xiao, H.; Banerjee, S.; Yu, Y.; Galanternik, M. V.; Weinstein, B. M.; Eberhart, C. G.; Mumm, J. S.; Raabe, E. H.
10.1101/2025.03.31.646163 — cancer biology — Posted on 2025-04-03
4753 EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs
Yi, H.; Zhang, S.; Swinderman, J.; Wang, Y.; Kanakaveti, V.; Hung, K. L.; Wong, I. T.-L.; Srinivasan, S.; Curtis, E. J.; Bhargava-Shah, A.; Li, R.; Jones, M. G.; Luebeck, J.; Zhao, Y.; Belk, J. A.; Kraft, K.; Shi, Q.; Yan, X.; Pritchard, S. K.; Liang, F. M.; Felsher, D. W.; Gilbert, L. A.; Bafna, V.; Mischel, P. S.; Chang, H.
10.1101/2025.04.01.646515 — cancer biology — Posted on 2025-04-03
4754 Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis
Xu, J.; Scoca, V.; Chen, Y.; Zhan, Y. A.; Fisher, A.; Udoh, E.-o.; Fernando, S.; Alija, B.; Pantazi, J.; Sudunagunta, V.; Stewart, E.; Galang, A. M. D.; Williams, M.; Bhagat, G.; Gebhard, C.; Visconte, V.; Ondrejka, S.; Delwel, R.; Hu, M.; Koche, R. P.; Viny, A. D.
10.1101/2025.04.01.646632 — cancer biology — Posted on 2025-04-03
4755 Boosting Antitumour Efficacy and Immunity by Boron Neutron Capture Therapy with Size-Controlled Nanoparticles
Huang, W.; Kang, H. G.; Han, X.; Yu, J.; Chen, X.; Takata, T.; Sakurai, Y.; Suzuki, M.; Komatsu, N.
10.1101/2025.04.02.646946 — cancer biology — Posted on 2025-04-03
4756 Presence of Hepatitis B virus infection in colon cancer
Li, L.; Gong, W.; An, Y.; Tong, H.; Yang, M.; Wang, W.; Ma, L.; Tu, S.; Liu, Y.; duan, y.; Sun, K.
10.1101/2025.03.30.646256 — cancer biology — Posted on 2025-04-03
4757 Cysteine-Engineered CAR-T Cells to Counter Antigen Escape in B Cell Lymphoma
Luehle, J.; Krost, S.; Goerdeler, F.; Seitz, C.; Seeberger, P. H.; Moscovitz, O.
10.1101/2025.04.01.646520 — cancer biology — Posted on 2025-04-03
4758 Vitronectin binding affinity and cell viability effect of novel mechanotherapy drugs for neuroblastoma
Alaribe, S. C.; Granados-Aparici, S.; Oladipupo, A. R.; Vieco-Marti, I.; Titilayo, B. E.; Allen, G.; Noguera, R.
10.1101/2025.03.31.646300 — cancer biology — Posted on 2025-04-03
4759 Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis
Scholten, D.; El-Shennawy, L.; Jia, Y.; Zhang, Y.; Hyun, E.; Reduzzi, C.; Hoffmann, A. D.; Almubarak, H. F.; Tong, F.; Dashzeveg, N. K.; Sun, Y.; Squires, J. R.; Lu, J.; Platanias, L. C.; Wasserfall, C. H.; Gradishar, W. J.; Cristofanilli, M.; Fang, D.; Liu, H.
10.1101/2025.04.01.646421 — cancer biology — Posted on 2025-04-03
4762 Timing and clustering co-occurring genome amplifications incancers
Cocomello, S.; Santacatterina, G.; Bergamin, R.; Antonello, A.; Caravagna, G.
10.1101/2025.03.31.646456 — cancer biology — Posted on 2025-04-03
4763 The molecular chaperone TRAP1 promotes translation of Luc7l3 mRNA to enhance ovarian cancer cell proliferation
De Lella, S.; Pedalino, L.; Almagboul Abdalla Abaker, M.; Mignogna, C.; Cautiero, R.; Esposito, F.; Matassa, D. S.; Avolio, R.
10.1101/2025.04.01.646636 — cancer biology — Posted on 2025-04-03
4764 Single cell spatial transcriptomics identifies coordinated cellular programs that are associated with good prognosis in microsatellite stable colorectal cancer
Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.
10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-04-03
4766 HDL Nanodiscs Loaded with Liver X Receptor Agonist Decreases Tumor Burden and Mediates Long-term Survival in Mouse Glioma Model
Halseth, T. A.; Mujeeb, A. A.; Liu, L.; Banerjee, K.; Lang, N.; Hollon, T.; Yu, M.; Roest, M. V.; Mei, L.; He, H.; Sheth, M.; Castro, M. G.; Schwendeman, A.
10.1101/2025.04.01.646644 — cancer biology — Posted on 2025-04-03
4768 Entry and exit of Fragilariopsis cylindrus diatoms from the polar night: evidence for chromatin-mediated genome control
Joli, N.; Bourbousse, C.; Leduque, B.; Tirichine Delacour, L.; Laude, J.; Maumus, F.; Ait-Mohamed, O.; Klein, L.; Kusendo, B.; Concia, L.; Quadrana, L.; Barneche, F.; Babin, M.; Bowler, C.
10.1101/2025.04.02.646770 — genomics — Posted on 2025-04-03
4769 Mammal responses to habitat degradation induced by cashew expansion in West Africa
Na Mone, D.; Nhasse, I.; Soares, J.; Oliveira, R.; Lopes-Lima, M.; Palma, L.; Palmeirim, A. F.
10.1101/2025.03.29.646115 — ecology — Posted on 2025-04-03
4770 Genetic basis of cuticular hydrocarbon variation in the desert ant
Inbar, S.; Saied, B.; Cohen, P.; Frenkel, Z.; Pellen, Y.; Korol, A. B.; Privman, E.
10.1101/2025.03.30.646157 — ecology — Posted on 2025-04-03
4771 Thymidine kinase-independent click chemistry DNADetect™ probes as an EdU alternative for mammalian cell DNA labelling
Macdonald, J. R.; Fisher, G. M.; Braun, A.-S. C.; Thomas, S.; Skinner-Adams, T. S.; Hilko, D. H. H.; Poulsen, S.-A.; Andrews, K. T.
10.1101/2025.04.02.646904 — cell biology — Posted on 2025-04-03
4772 5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins
Hayes, L. R.; Zaepfel, B.; Duan, L.; Starner, A. C.; Bartels, M. D.; Rothacher, R. L.; Martin, S.; French, R.; Zhang, Z.; Sinha, I. R.; Ling, J. P.; Sun, S.; Ayala, Y. M.; Coller, J.; Van Nostrand, E. L.; Florea, L.; Kalab, P.
10.1101/2025.04.02.646885 — cell biology — Posted on 2025-04-03
4776 Long-term iododeoxyuridine labelling analysis finds no evidence of ovarian germline stem cell activity in adult or ageing mice
Onochie, C. M.; Alamri, A.; Kostanjevec, K.; Brown, A. F.; Burton, S. L.; Koigi, S. S.; Wattie, S. L.; Collinson, J. M.
10.1101/2025.04.01.646696 — cell biology — Posted on 2025-04-03
4777 Identification of Omaveloxolone as An Endoplasmic Reticulum Associated Degradation Inhibitor That Induces Early Apoptotic Signaling in Multiple Myeloma
Kropp, E. M.; Matono, S.; Wang, O. Y.; Bobida, A. M.; Kandarpa, M.; Grant, J. L.; Oleson, B. J.; Alt, A.; Talpaz, M.; Pianko, M.; Li, Q. M.
10.1101/2025.04.02.646787 — cell biology — Posted on 2025-04-03
4779 CtBP1 coordinates synaptic, metabolic and contractile changes induced by denervation in skeletal muscle
Cattaneo, O.; Lopez, G.; Rajendran, J.; Chabry, F.; Prola, A.; Liaudet, N.; Startchik, S.; Castets, P.
10.1101/2025.03.29.646097 — physiology — Posted on 2025-04-03
4781 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma
Abounader, R.; Saha, S.; Zhang, Y.; Gibert, M. K.; Dube, C.; Hanif, F.; Mulcahy, E.; Bednarek, S.; Marcinkiewicz, P.; Wang, X.; Kwak, G.; Hudson, K.; Sun, Y.; Dinda, M.; Saha, T.; Guessous, F.; Cruickshanks, N.; Colon, R. R.; Dell'Olio, L. G.; Anbu, R.; Kefas, B.; Kumar, P.; Klibanov, A. L.; Schiff, D.; Suk, J. S.; Hanes, J.; Mata, J.; Hafner, M.
10.1101/2025.04.01.646663 — cancer biology — Posted on 2025-04-03
4782 Single cell transcriptional evolution of myeloid leukaemia of Down syndrome
Trinh, M. K.; Schuschel, K.; Issa, H.; Thomas, R.; Parks, C.; Oszlanczi, A.; Ogbonnah, T.; Zhou, D.; Mamanova, L.; Prigmore, E.; Robertson, E.; Hodder, A.; Wenger, A.; Anderson, N. D.; Whitfield, H. J.; Treger, T. D.; Goncalves Dias, J.; Straathof, K.; O'Connor, D.; Young, M. D.; Jardine, L.; Adams, S.; Klusmann, J.-H.; Bartram, J.; Behjati, S.
10.1101/2025.04.01.646181 — cancer biology — Posted on 2025-04-03
4791 Apusomonad rhodopsins, a new family of ultraviolet to blue light absorbing rhodopsin channels
Galindo, L. J.; Takaramoto, S.; Nagata, T.; Rozenberg, A.; Takahashi, H.; Beja, O.; Inoue, K.
10.1101/2025.04.02.646541 — biophysics — Posted on 2025-04-03
4795 WITHDRAWN: DNA polymerase {lambda}-driven targeted mutagenesis fordirected evolution in human cells
Aiello, D.; Ciciani, M.; Marelli, F.; Stancampiano, M.; De Sanctis, V.; Bertorelli, R.; Kheir, E. G. A.; Maule, G.; Cereseto, A.; Arosio, D.
10.1101/2024.07.23.604813 — molecular biology — Posted on 2025-04-03
4796 Millisecond-Scale White Matter Dynamics Underlying Visuomotor Integration
Ueda, R.; Uda, H.; Hatano, K.; Sakakura, K.; Kuroda, N.; Kitazawa, Y.; Kanno, A.; Lee, M.-H.; Jeong, J.-W.; Luat, A. F.; ASANO, E.
10.1101/2025.03.28.646029 — neuroscience — Posted on 2025-04-03
4797 A Wildlife Health Outbreak Response Table-top Exercise for Pandemic Preparedness Planning
Ahyong, V.; Ayscue, P.; Gowen, R.; Spottiswoode, N.; Alex, C. E.; Anis, E.; Beiting, D. P.; Gibison, M.; Gordian-Rivera, E. I.; Greening, S.; Keatts, L.; Larsen, R. S.; Miller, E.; Niewinski, B.; Gagne, R. B.; Tato, C. M.; Ellis, J.; Murphy, L.
10.1101/2025.04.01.646690 — scientific communication and education — Posted on 2025-04-03
4798 Estimating the replicability of Brazilian biomedical science
Amaral, O. B.; Carneiro, C. F. D.; Neves, K.; Sampaio, A. P. W.; Gomes, B. V.; Abreu, M. B. d.; Tan, P. B.; Mota, G. P. S.; Goulart, R. N.; Fernandes, N. R. d. S.; Linhares, J. H.; Ibelli, A. M. G.; Sebollela, A.; Andricopulo, A. D.; Carvalho, A. A. V. d.; Silva, A. P. e.; Souza, A. S. O.; Lima, A. C. C. d.; Sousa, A. M. d.; Birbrair, A.; Borbely, A. U.; Machado, A. M.; Costa, A. d. C.; Vasconcelos, A. P. d.; Silva, A. H. B. d. L.; Souza, A. d.; Herrmann, A. P.; Bastos, A. P. A.; Nunes, A. C. C.; Castrucci, A. M. d. L.; Paula, A. B. R.; Waltrick, A. P. F.; Macedo, A. G. F. d.; Mecawi, A. S.; R
10.1101/2025.04.02.645026 — scientific communication and education — Posted on 2025-04-03
4808 Human differentiated adipocytes can serve as surrogate mature adipocytes for adipocyte-derived extracellular vesicle analysis
Hade, M. D.; Butsch, B. L.; Palacio, P. L.; Nguyen, K. T.; Shantaram, D.; Noria, S.; Brethauer, S. A.; Needleman, B. J.; Hsueh, W.; Reategui, E.; Magana, S. M.
10.1101/2025.02.05.636729 — cell biology — Posted on 2025-04-03
4810 Surveillance of Japanese Encephalitis Virus in Piggery Effluent and Environmental Samples: A Complementary Tool for Outbreak Detection
Ahmed, W.; Gebrewold, M.; Williams, D. T.; Wang, J.; Smith, W.; Starick, L. G.; Fogarty, R. M.; Richards, K.; Simpson, S.
10.1101/2025.03.27.645166 — molecular biology — Posted on 2025-04-03
4813 White Matter Hyperintensities Precede other Biomarkers in GRN Frontotemporal Dementia
Soltaninejad, M.; Dadar, M.; Collins, D. L.; Rajabli, R.; Venkatraghavan, V.; Bouzigues, A.; Russell, L. L.; Foster, P. H.; Ferry-Bolder, E.; van Swieten, J. C.; Jiskoot, L. C.; Seelaar, H.; Sanchez-Valle, R.; Laforce, R.; Graff, C.; Galimberti, D.; Vandenberghe, R.; de Mendonca, A.; Tiraboschi, P.; Santana, I.; Gerhard, A.; Levin, J.; Nacmias, B.; Otto, M.; Bertoux, M.; Lebouvier, T.; Butler, C. R.; Le Ber, I.; Finger, E.; Tartaglia, M. C.; Masellis, M.; Rowe, J. B.; Synofzik, M.; Moreno, F.; Borroni, B.; Rohrer, J. D.; Iturria-Medina, Y.; Ducharme, S.
10.1101/2025.03.31.646450 — neuroscience — Posted on 2025-04-03
4814 Neural entrainment to pitch changes of auditory targets in noise
Guo, X.; Mai, G.; Mohammadi, Y.; Benzaquen, E.; Yukhnovich, E.; Sedley, W.; Griffiths, T. D.
10.1101/2025.04.03.646585 — neuroscience — Posted on 2025-04-03
4815 GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction
Raju, K.; Joy, D.; Guldberg, S. M.; Germain, K.; Gould, N.; Ha, C.; Tatarakis, D.; Dugas, J. C.; Davis, S.; Reeves, A.; Andrews, S. V.; Weerakkody, T.; Suh, J.; Lunkes de Melo, G.; Xiong, K.; Lightfoot, Y.; Propson, N.; Sandmann, T.; Di Paolo, G.; Lewcock, J. W.; Ray, W. J.; Monroe, K.
10.1101/2025.03.28.646038 — neuroscience — Posted on 2025-04-03
4817 Cortical motor activity modulates respiration and reduces apnoea in neonates
Zandvoort, C. S.; Usman, F.; Robinson, S.; Fatunla, O.; Adams, E.; Pattinson, K. T. S.; Farmer, S. F.; Hartley, C.
10.1101/2025.04.03.646882 — neuroscience — Posted on 2025-04-03
4818 Male obesity causes adipose mitochondrial dysfunction in F1 progeny via a let-7-DICER axis.
Huang, C.; Park, J.-H.; Altintas, A.; Stanic, N.; de Leon, K. K.; Isacson, S.; Kalogeropoulos, P.; Batarlar, H. T.; Malmros, R. V.; Havelund, J.; Marcher Larsen, B. D.; Chien, Y.-T.; Huang, W.-C.; Szczepanowska, K.; Lackmann, J.-W.; Trifunovic, A.; Hejbol, E. K.; Detlefsen, S.; Jepsen, I. E.; Kolstrup, S. H.; Laguna Barraza, R. A.; Gonzalez, J.-M.; Khodosevich, K.; Faergeman, N. J.; Mori, M. A.; Friedländer, M. R.; Oest, A.; Barres, R.; Kornfeld, J.-W.
10.1101/2024.10.03.615866 — physiology — Posted on 2025-04-03
4819 Caveolin assemblies displace one bilayer leaflet to organize and bend membranes
Doktorova, M.; Daum, S.; Reagle, T. R.; Cannon, H. I.; Ebenhan, J.; Neudorf, S.; Han, B.; Sharma, S.; Kasson, P.; Levental, K.; Bacia, K.; Kenworthy, A. K.; Levental, I.
10.1101/2024.08.28.610209 — biophysics — Posted on 2025-04-03
4822 Expression spectrum of TE-derived transcripts in human adult tissues
Miao, B.; Zhang, B.; WU, T. P.; Luo, X.; Ademovic, A.; Yang, Y.
10.1101/2025.03.29.646092 — genomics — Posted on 2025-04-03
4823 A novel supergene controls queen size and colony social organization in the ant Myrmica ruginodis
Sigeman, H.; Seppä, P.; Downing, P. A.; Webster, M. T.; Helanterä, H.; Viljakainen, L.
10.1101/2025.03.24.644106 — evolutionary biology — Posted on 2025-04-03
4828 Lower Aperiodic EEG Activity is Associated with Reduced Verbal Fluency Performance Across Adulthood
McKeown, D. J.; Roberts, E.; Finley, A. J.; Kelley, N. J.; Keage, H. A. D.; Schinazi, V. R.; Baumann, O.; Moustafa, A. A.; Angus, D. J.
10.1101/2024.08.13.607827 — neuroscience — Posted on 2025-04-03
4829 A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers
Stewart, R. G.; Marquis, M. J.; Jo, S.; Harris, B.; Aberra, A.; Cook, V.; Whiddon, Z.; Yarov-Yarovoy, V.; Ferns, M.; Sack, J. T.
10.1101/2024.01.31.578214 — neuroscience — Posted on 2025-04-03
4832 BioPKS Pipeline: An integrated platform for merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis
Chainani, Y.; Diaz, J.; Guilarte-Silva, M.; Blay, V.; Zhang, Q.; Sprauge, W.; Tyo, K.; Broadbelt, L. J.; Mukhopadhyay, A.; Keasling, J. D.; Martin, H. G.; Backman, T. W. H.
10.1101/2024.11.04.621673 — bioinformatics — Posted on 2025-04-03
4834 Overcoming myeloid-driven resistance to CAR T therapy by targeting SPP1
Gholamin, S.; Natri, H. M.; Zhao, Y.; Xu, S.; Aftabizadeh, M.; Comin-Anduix, B.; Saravanakumar, S.; Masia, C.; Wong, R. A.; Peter, L.; Chung, M.-i.; Mee, E. D.; Aguilar, B.; Starr, R.; Torrejon, D. Y.; Alizadeh, D.; Wu, X.; Kalbasi, A.; Ribas, A.; Forman, S.; Badie, B.; Banovich, N.; Brown, C.
10.1101/2025.04.01.646202 — cancer biology — Posted on 2025-04-03
4836 Green cities and the risk for vector-borne disease transmission for humans and animals: a scoping review
Mercat, M.; Bartholomee, C.; Fournet, F.; Alcover Amengual, M.; Bourquia, M.; Bouhsira, E.; Cornel, A.; Fernandez-Cassi, X.; Fontenille, D.; Ibanez-Justicia, A.; Marti, R.; Moiroux, N.; Niang, E. H.; Smith, W.; Spitzen, J.; Visser, T.; Koenraadt, C. J. M.; Simard, F.
10.1101/2025.04.01.646559 — ecology — Posted on 2025-04-03
4840 Mapping the coupling between tract reachability and cortical geometry of the human brain
Li, D.; Zalesky, A.; Wang, Y.; Wang, H.; Ma, L.; Cheng, L.; Banaschewski, T.; Barker, G. J.; Bokde, A. L.; Brühl, R.; Desrivieres, S.; Flor, H.; Garavan, H.; Gowland, P. A.; Grigis, A. A.; Heinz, A.; LEMAITRE, H.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; Nees, F.; Orfanos, D. P.; Poustka, L.; Smolka, M. N.; Vaidya, N.; Walter, H.; Whelan, R.; Schumann, G.; Jia, T.; Chu, C.; Fan, L.
10.1101/2025.03.31.646498 — neuroscience — Posted on 2025-04-03
4842 CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species
Kempynck, N.; De Winter, S.; Blaauw, C. H.; Konstantakos, V.; Dieltiens, S.; Eksi, E. C.; Bercier, V.; Taskiran, I. I.; Hulselmans, G.; Spanier, K.; Christiaens, V.; Van Den Bosch, L.; Mahieu, L.; Aerts, S.
10.1101/2025.04.02.646812 — genomics — Posted on 2025-04-03
4843 Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5
Strell, P.; Waldron, M. A.; Johnson, S.; Shetty, A. V.; Crane, A.; Steer, C.; Low, W. C.
10.1101/2025.03.31.646380 — developmental biology — Posted on 2025-04-02
4844 CHD7 binds distinct regions in the Sox11 locus to regulate neuronal differentiation
Martinez, E.; Jadali, A.; Qiu, J.; Hinman, A. M.; Ni, J. Z.; Kim, J.; Kwan, K. Y.
10.1101/2025.04.02.646816 — molecular biology — Posted on 2025-04-03
4845 APOE genotype-dependent differences in human astrocytic energy metabolism
Budny, V.; Bodenmann, C.; Zuercher, K. J.; de Leeuw, S. M.; Weber, R. Z.; Ravotto, L.; Ruminot, I.; Barros, L. F.; Weber, B.; Tackenberg, C.
10.1101/2025.03.31.646283 — neuroscience — Posted on 2025-04-02
4846 Non-linear and time-domain sleep qEEG features predict CSF protein damage markers in early Alzheimers disease
Gaeta, A. M.; Vinaras, L. G.; Barbe, F.; Olmos, P. M.; Pamplona, R.; Dakterzada, F.; Munoz-Barrutia, A.; Pinol-Ripoll, G.
10.1101/2025.03.28.645905 — neuroscience — Posted on 2025-04-02
4847 Common and distinct neural mechanisms of aversive and appetitive pain-related learning
Li, J.; Schmidt, K.; Busch, L.; Forkmann, K.; Spisak, T.; Kaur, J.; Schlitt-Nguyen, F.; Wiech, K.; Bingel, U.
10.1101/2025.04.02.646781 — neuroscience — Posted on 2025-04-03
4850 Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles
Nowak, J. A.; Cho, E.; Davis, M. A.; Zheng, S.; Bell, L.; Sha, F.; Magdalenski, J. S.; Farha, O. K.; Teplensky, M. H.
10.1101/2025.03.28.645811 — bioengineering — Posted on 2025-04-02
4852 The photoreaction process of a large-Stokes-shift red fluorescence protein-LSSmCherry1
Li, G.; Meng, J.; Bai, X.; Zhao, S.; Hu, Y.; Dai, J.; Song, Y.; Peng, X.; Zhao, Q.
10.1101/2025.04.01.646287 — biochemistry — Posted on 2025-04-02
4854 Beyond genetic indicators: how reproductive mode and hybridization challenge freshwater mussel conservation
Faust, E.; Conrads, J.; Giulio, M.; Ciofi, C.; Natali, C.; Feulner, P. G.; Weber, A. A.-T.
10.1101/2025.03.28.645956 — genomics — Posted on 2025-04-02
4855 A Bayesian approach to include Indigenous Knowledge in habitat selection functions
Gryba, R.; Von Duyke, A. L.; Huntington, H. P.; Adams, B.; Frantz, B.; Gatten, J.; Harcharek, Q.; Sarren, R.; Henry, G. H.; Auger-Methe, M.
10.1101/2025.03.26.645387 — ecology — Posted on 2025-04-02
4856 An adult clock regulator links circadian rhythms to pancreatic β-cell maturation
Montalvo, A. P.; Gao, Z.; Liu, M.; Gruskin, Z. L.; Leduc, A.; Preza, S.; Xie, Y.; Rozo, A. V.; Ahn, J. H.; Straubhaar, J. R.; Doliba, N.; Stoffers, D.; Slavov, N.; Alvarez-Dominguez, J. R.
10.1101/2023.08.11.552890 — cell biology — Posted on 2025-04-02
4857 Interleukin-13-mediated alterations in esophageal epithelial mitochondria contribute to tissue remodeling in eosinophilic esophagitis
Jackson, J. L.; Saxena, R.; Murray, M. G.; Staub, A. J.; Klochkova, A.; Bordner, T. H.; Worrell, C.; Fuller, A. D.; Crespo, J. M.; Klein-Szanto, A. J.; Elrod, J.; Karakasheva, T. A.; Ruffner, M.; Muir, A. B.; Whelan, K. A.
10.1101/2025.04.02.646853 — molecular biology — Posted on 2025-04-02
4859 The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture
Navarro, P. P.; Vettiger, A.; Hajdu, R.; Ananda, V. Y.; Lopez-Tavares, A.; Schmid, E.; Walter, J.; Loose, M.; Chao, L. H.; Bernhardt, T. G.
10.1101/2025.04.02.646830 — microbiology — Posted on 2025-04-02
4860 Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability
Garcia, J. D.; Wang, C.; Alexander, R.; Banks, E.; Fenton, T.; DeKeyser, J.-M.; Abramova, T. V.; George, A. L.; Ben-Shalom, R.; Hackos, D. H.; Bender, K. J.
10.1101/2024.12.17.629038 — neuroscience — Posted on 2025-04-02
4861 Metabolic task analysis reveals distinct metabotypes in end-stage dilated cardiomyopathy
Nihant, B.; Verdonschot, J.; Balan, S.; Thielecke, E.; Luiken, J.; Nabben, M.; Heymans, S.; Breuer, M.; Adriaens, M.
10.1101/2025.03.28.645901 — systems biology — Posted on 2025-04-02
4862 Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait loci
Soenksen, J.; Chen, J.; Varshney, A.; Martin, S.; MAGIC, ; Parker, S. C. J.; Morris, A. P.; Asimit, J. L.; Barroso, I.
10.1101/2024.11.13.623384 — genetics — Posted on 2025-04-02
4865 Genetic risk in endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease
Mamde, S.; Rose, S.; Prater, K. E.; Cochoit, A.; Lin, Y. F.; Smith, I.; Johnson, C. S. C.; Reid, A.; Qiu, W.; Strohbehn, S.; Keene, C. D.; Rolf, B.; Lin, K.; Lee, S.-I.; Garden, G.; Blue, E.; Young, J. E.; Jayadev, S.
10.1101/2025.03.16.643481 — neuroscience — Posted on 2025-04-02
4867 Intrinsic dynamic shapes responses to external stimulation in the human brain
Nentwich, M.; Leszczynski, M.; Schroeder, C. E.; Bickel, S.; Parra, L. C.
10.1101/2024.08.05.606665 — neuroscience — Posted on 2025-04-02
4868 A systems biology investigation to identify potential bi-omarkers in leprosy-affected host cells.
Chowdhury, S.; Ansari, A.; Verma, P.; Mavlankar, A.; Tripathi, A.; Pena, M.; Sharma, R.; Caskey, J.; Truman, R.; Singh, P.
10.1101/2025.03.28.646010 — systems biology — Posted on 2025-04-02
4873 Relationship between melanoma vemurafenib tolerance thresholds and metabolic pathway choice and Wnt signaling involvement
Nangia-Makker, P.; Ahrens, M.; Purandare, N.; Aras, S.; Li, J.; Gurdziel, K.; Jang, H.; Kim, S.; Shekhar, M. P.
10.1101/2025.03.06.641924 — cancer biology — Posted on 2025-04-02
4878 Efficient Design of Affilin(R) Protein Binders for HER3
Diaz-Rovira, A. M.; Lotze, J.; Hoffmann, G.; Pallara, C.; Molina, A.; Coburger, I.; Gloser-Bräunig, M.; Meysing, M.; Zwarg, M.; Diaz, L.; Guallar, V.; Bosse-Doenecke, E.; Roda, S.
10.1101/2025.04.02.646551 — biochemistry — Posted on 2025-04-02
4881 Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina
Yuan, Y.; Biswas, P.; Zemke, N.; Dang, K.; Wu, Y.; D Antonio, M.; Xie, Y.; Yang, Q.; Dong, K.; Lau, P. K.; Li, D.; Seng, C.; Bartosik, W.; Buchanan, J.; Lin, L.; Lancione, R.; Wang, K.; Lee, S.; Gibbs, Z.; Ecker, J.; Frazer, K.; Wang, T.; Preissl, S.; Wang, A.; Ayyagari, R.; Ren, B.
10.1101/2024.12.28.630634 — genomics — Posted on 2025-04-02
4883 AquIRE reveals multiple mechanisms of clinically induced RNA damage and the conservation and dynamics of glycoRNAs
Zhang, Z.; Kotopanova, Z. V.; Dang, K.; Kong, X.; Simms, N.; Yuen, T. W.; Sonmez, A.; Beadle, L. F.; Hilton, E.; Qureshi, T.; Coppola, M.; Holmes, C. D.; Kan, K. T.; Ashe, M.; Gallois, P.; Ashe, H.; Lafontaine, D. L.; Braun, M.; Saunders, M.; Sutton, P.; Thornton, D.; Knight, J. R.
10.1101/2025.04.01.646554 — molecular biology — Posted on 2025-04-02
4888 Parkinson's Paradox: Alpha-synuclein's Selective Strike on SNc Dopamine Neurons over VTA
Phan, L.; Miller, D.; Gopinath, A.; Gunther, D.; Kiel, K.; Quintin, S.; Borg, D.; Hasanpour-Segherlou, Z.; Newman, A.; Sorrentino, Z.; Miller, E.; Seibold, J.; Hoh, B.; Giasson, B.; Khoshbouei, H.
10.1101/2025.03.24.644952 — neuroscience — Posted on 2025-04-02
4889 A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model
Fitzpatrick, M. K.; Dyson, C.; Beeson, A.; Adrian, L.; Marrs, G.; Grzybowski, M.; Klotz, J.; Geurts, A. M.; Chen, R.; Weiner, J. L.; Woods, L. C. S.
10.1101/2025.03.28.645767 — neuroscience — Posted on 2025-04-02
4893 Rapid optimization of protein function in mammalian cells via microbe-independent deep assembly and screening
Wu, Y.; Wang, P.; Liu, L. X.; Gao, C.; Qin, Q.; Hageman, M.; Kirkland, T. A.; Su, Y.; Lin, M. Z.
10.1101/2025.03.30.646252 — bioengineering — Posted on 2025-04-02
4894 UniversalEPI: a generalized attention-based deep ensemble model to accurately predict enhancer-promoter interactions across diverse cell types and conditions
Grover, A.; Zhang, L.; Muser, T.; Häfliger, S.; Wang, M.; Yates, J.; Van Allen, E.; Theis, F. J.; Ibarra, I. L.; Krymova, E.; Boeva, V.
10.1101/2024.11.22.624813 — genomics — Posted on 2025-04-02
4895 Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy
King, E. S.; Stacy, A. E.; Weaver, D. T.; Maltas, J. A.; Barker-Clarke, R.; Dolson, E.; Scott, J. G.
10.1101/2022.06.10.495696 — evolutionary biology — Posted on 2025-04-02
4897 Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma
Hough, K. P.; Trevor, J. L.; Ahmad, S.; Wang, Y.; Chacko, B. K.; Goliwas, K. F.; Strenkowski, J. G.; Bone, N. B.; Kim, Y.-i.; Holmes, R.; Liu, Y.; Vang, S.; Pritchard, A.; Chin, J.; Bodduluri, S.; Antony, V. B.; Tousif, S.; Athar, M. S.; Chanda, D.; Mitra, K.; Zmijewski, J.; Zhang, J.; Duncan, S. R.; Thannickal, V. J.; Gabrielsson, S.; Darley-Usmar, V. M.; Deshane, J. S.
10.1101/2024.04.30.589227 — immunology — Posted on 2025-04-02
4898 Music-selective cortex is sensitive to structure in both pitch and time
Boebinger, D. L.; McDermott, J. H.; Kanwisher, N. G.; Norman-Haignere, S. V.
10.1101/2021.12.17.473232 — neuroscience — Posted on 2025-04-02
4899 An Open-Source Deep Learning-Based GUI Toolbox For Automated Auditory Brainstem Response Analyses (ABRA)
Erra, A.; Chen, J.; Miller, C.; Chrysostomou, E.; Barret, S.; Kassim, Y. M.; Friedman, R. A.; Lauer, A.; Ceriani, F.; Marcotti, W.; Carroll, C.; Manor, U.
10.1101/2024.06.20.599815 — neuroscience — Posted on 2025-04-02
4901 Mu and delta opioid receptor antagonists increase the expression of social conditioned place preference in early adolescent mice
Harda, Z.; Klimczak, M.; Misiolek, K.; Chroszcz, M.; Rzeszut, A.; Szumiec, L.; Jarosz, M. K.; Rygula, R.; Ziolkowska, B.; Parkitna, J. R.
10.1101/2023.07.19.549691 — neuroscience — Posted on 2025-04-02
4903 Cortical structure in relation to empathy and psychopathy in 800 incarcerated men
Radecki, M. A.; Maurer, J. M.; Harenski, K. A.; Stephenson, D. D.; Sampaolo, E.; Lettieri, G.; Handjaras, G.; Ricciardi, E.; Rodriguez, S. N.; Neumann, C. S.; Harenski, C. L.; Palumbo, S.; Pellegrini, S.; Decety, J.; Pietrini, P.; Kiehl, K. A.; Cecchetti, L.
10.1101/2023.06.14.543399 — neuroscience — Posted on 2025-04-02
4907 Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus formation
Ankenbauer, K. E.; Yang, Y.; Chung, C.-Y.; Andrade, L. R.; Weiser Novak, S.; Jarvis, B.; Ali Hanel, W. H.; Liu, J.; Sarkisian, V.; Dani, N.; Krystofiak, E.; Hu, G.; Ebrahim, S.; Kachar, B.; Gong, Q.; Wahl, G.; Manor, U.; Lau, K.; DelGiorno, K. E.
10.1101/2025.03.18.644042 — cell biology — Posted on 2025-04-02
4909 Common biological features of Mycobacterium tuberculosis MmpL3 inhibitors
Ames, L.; Allen, R.; Boshoff, H. I.; Cleghorn, L.; Engelhart, C. A.; Schnappinger, D.; Parish, T.
10.1101/2025.03.31.646319 — microbiology — Posted on 2025-04-02
4910 Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery
Haudiquet, M.; Chakravarti, A.; Zhang, Z.; Ramirez, J. L.; Herrero del Valle, A.; Olinares, P. D. B.; Lavenir, R.; Aït Ahmed, M.; de la Cruz, M. J.; Chait, B.; Sternberg, S. H.; Bernheim, A.; Patel, D.
10.1101/2025.04.02.646746 — microbiology — Posted on 2025-04-02
4911 Synaptic Gpr85 influences cerebellar granule cells electrical properties and light-induced behavior.
Darche-Gabinaud, R.; Kaafarani, A.; Chazalon, M.; Suain, V.; Hendrickx, E.; Conrard, L.; Lefort, A.; Libert, F.; Demirler, M. C.; Schiffmann, S.; Perez-Morga, D.; Wittamer, V.; Parmentier, M.; Pirson, I.
10.1101/2025.03.10.642364 — neuroscience — Posted on 2025-04-02
4912 RNAi-based screen for pigmentation in Drosophila melanogaster reveals regulators of brain dopamine and sleep
Deal, S. L.; Bei, D.; Gibson, S. B.; Delgado-Seo, H.; Fujita, Y.; Wilwayco, K.; Seto, E. S.; Yamamoto, S.
10.1101/2023.07.20.549932 — neuroscience — Posted on 2025-04-02
4914 Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging
Potenza, D. M.; Cheng, X.; AJALBERT, G.; Brenna, A.; Giraud, M.-N.; FROBERT, A.; Cook, S.; Mertz, K. D.; Yang, Z.; Ming, X.-F.
10.1101/2024.01.17.576017 — physiology — Posted on 2025-04-02
4916 Toward De Novo Protein Design from Natural Language
Dai, F.; You, S.; Wang, C.; Fan, Y.; Su, J.; Han, C.; Zhou, X.; Liu, J.; Qian, H.; Wang, S.; Zeng, A.; Wang, Y.; Lu, H.; Yuan, F.
10.1101/2024.08.01.606258 — bioengineering — Posted on 2025-04-02
4917 In vivo activation of the dia BGC allows consolidation of the biosynthetic pathways of diaporthin, dichlorodiaporthin, diaporthinic acid, and diaporthinol
Burger, I.; Leonhartsberger, S.; Peikert, K.; Fourtis, L.; Atanasova, P.; Kramer, L. T.; Fried, R.; Stanetty, C.; Rudroff, F.; Birner-Gruenberger, R.; Mach, R. L.; Mach-Aigner, A. R.; Schittmayer, M.; Zimmermann, C.
10.1101/2025.03.31.646288 — biochemistry — Posted on 2025-04-02
4923 Lactuchelins: New lipopeptide siderophores from Pseudomonas lactucae inhibit Xanthomonas campestris pv. campestris 8004
Chesneau, G.; Noel, A.; Breard, D.; Boulanger, A.; Briand, M.; Bonneau, S.; Liu, Y.; Hendrickson, A.; Nielsen, T.; Sarniguet, A.; Guilet, D.; Arkin, A.; Lui, L.; BARRET, M.
10.1101/2025.02.28.640635 — microbiology — Posted on 2025-04-02
4926 Neuronal correlates of sleep in honey bees
Moguilner, S.; Tiraboschi, E.; Fantoni, G.; Strelevitz, H.; Soleimani, H.; Del Torre, L.; Hasson, U.; Haase, A.
10.1101/2024.10.11.617548 — neuroscience — Posted on 2025-04-02
4928 CREPE (CREate Primers and Evaluate): a computational tool for large-scale primer design and specificity analysis
Pitsch, J. W.; Wirth, S. A.; Costantino, N. T.; Mejia, J.; Doss, R. M.; Yang, X.; Breuss, M. W.
10.1101/2025.03.28.646040 — genetics — Posted on 2025-04-02
4932 Gene expression cartography of a developing neuronal structure
Tadini, L.; Younsi, L.; Holguera, I.; Simon, F.; Courgeon, M.; Konstantinides, N.
10.1101/2025.03.30.646184 — developmental biology — Posted on 2025-04-02
4934 Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand
Achieng, M. A.; Schnell, J.; Fausto, C. C.; Csipan, R. L.; Thornton, M. E.; Grubbs, B. H.; Lindström, N. O.
10.1101/2025.03.29.646044 — developmental biology — Posted on 2025-04-02
4936 Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy
Duursma, I.; Nollet, E. E.; Jansen, V. J.; Malone, J. A.; Bloem, J. S.; Bedi, K.; Margulies, K. B.; Schoonvelde, S. A. C.; Michels, M.; van der Wel, N. N.; van der Velden, J.; Kirby, T. J.; Kuster, D. W. D.
10.1101/2025.03.28.646061 — physiology — Posted on 2025-04-02
4939 Machine learning-predicted chromatin organization landscape across pediatric tumors
Gjoni, K.; Zhang, S.; Yan, R. E.; Zhang, B.; Miller, D.; Resnick, A.; Dahmane, N.; Pollard, K. S.
10.1101/2025.03.28.645984 — genomics — Posted on 2025-04-02
4940 Robust Phylogenetics
Liu, Q.; Minh, B. Q.; Lanfear, R.; Charleston, M. A.; Richards, S. A.; Holland, B. R.
10.1101/2025.04.01.646540 — evolutionary biology — Posted on 2025-04-02
4941 Cross-species insemination reveals mouse sperm ability to locate and cross the fish micropyle
Garibova, S.; Stickler, E.; AlAli, F.; Abdulla, M. A.; Sathappan, A.; Da'as, S.; Ghanem, L.; Portman, R.; Avella, M.
10.1101/2025.03.29.646094 — developmental biology — Posted on 2025-04-02
4942 Casein kinase 1δ-regulated formation of GVBs induces resilience to tau pathology-mediated protein synthesis impairment
Smits, J. F. M.; Ligthart, T. W.; Jorge-Oliva, M.; Middelhoff, S.; Schipper, F.; Garritsen, R.; Pita-Illobre, D.; Li, K. W.; Scheper, W.
10.1101/2025.03.28.645932 — neuroscience — Posted on 2025-04-02
4943 Mosquito Sex Separation using Complementation of Selectable Traits and Engineered Neo-Sex Chromosomes
Zaada, D. S.; Toren, O.; Krsticevic, F.; Haber, D. A.; Gildman, D.; Galpaz, N.; Haecker, I.; Schetelig, M. F.; Marois, E.; Arien, Y.; Papathanos, P. A.
10.1101/2025.03.30.646185 — synthetic biology — Posted on 2025-04-02
4944 Functional genomics of Campylobacter-host interactions in an intestinal tissue model reveals a small lipoprotein essential for flagellar assembly
Alzheimer, M.; Froschauer, K.; Svensson, S. L.; Koenig, F.; Hopp, E.; Drobnic, T.; Henderson, L. D.; Ribardo, D. A.; Hendrixson, D. R.; Bischler, T.; Beeby, M.; Sharma, C. M.
10.1101/2025.04.02.646747 — microbiology — Posted on 2025-04-02
4949 In vivo efficacy of L-ascorbic acid in restricting cholera pathogenesis
Halder, P.; Sen, H.; Das, S.; Nandy, P.; Mukhopadhyay, A. K.; Withey, J. H.; Raychaudhuri, S.; Koley, H.
10.1101/2025.04.01.646656 — microbiology — Posted on 2025-04-02
4950 Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery
Haudiquet, M.; Chakravarti, A.; Zhiying, Z.; Ramirez, J. L.; Herrero del Valle, A.; Olinares, P. D. B.; Lavenir, R.; Aït Ahmed, M.; de la Cruz, M. J.; Chait, B.; Sternberg, S. H.; Bernheim, A.; Patel, D.
10.1101/2025.04.02.646746 — microbiology — Posted on 2025-04-02
4952 Immune-mediated indirect interaction between gut microbiota and bacterial pathogens
Keshavarz, M.; Franz, M.; Xie, H.; Zanchi, C.; Mbedi, S.; Sparmann, S.; Rolff, J.
10.1101/2025.03.31.646282 — immunology — Posted on 2025-04-02
4955 A computational approach to understanding effort-based decision-making in depression
Valton, V.; Mkrtchian, A.; Moses-Payne, M.; Gray, A.; Kieslich, K.; VanUrk, S.; Samborska, V.; Halahakoon, D. C.; Manohar, S. G.; Dayan, P.; Husain, M.; Roiser, J. P.
10.1101/2024.06.17.599286 — neuroscience — Posted on 2025-04-02
4957 Plant genetic and root-associated microbial diversity modulate Lactuca sativa responsiveness to a soil inoculum under phosphate deficiency
Capparotto, A.; Salvucci, P.; Ciampanelli, A.; Sello, S.; Sudiro, C.; Clauw, P.; Altissimo, A.; Vuolo, F.; Giovannetti, M.
10.1101/2025.04.02.646582 — plant biology — Posted on 2025-04-02
4958 The multiomics landscape of small peptides encoded by long non-coding RNA-derived sORFs in rice
Chen, Z.; Lin, H.; Wei, L.; Wang, S.; Peng, T.; Song, W.; Wang, D.; Wu, Y.; Wu, L.; Wu, J.; Wang, Y.
10.1101/2025.04.01.646714 — plant biology — Posted on 2025-04-02
4962 Resistance variation and bacterial interactions shape the adaptation of a genetically diverse bacterial population to antimicrobial treatment
Batra, A.; Tueffers, L.; Haas, K.; Loeblein, T.; Botelho, J.; Habig, M.; Schuetz, D.; Sakalyte, G.; Buchholz, F.; Berrios-Caro, E.; Uecker, H.; Unterweger, D.; Schulenburg, H.
10.1101/2025.04.01.646401 — evolutionary biology — Posted on 2025-04-02
4964 Social evolution and absence of olfactory function in larval honey bees
Peng, T.; Chen, Z.; Ahmed, A. C.; Feng, Q.; Yeo, S.; Han, H.-S.; Robinson, G. E.
10.1101/2025.03.31.646396 — evolutionary biology — Posted on 2025-04-02
4965 Fighting Through the Heat: How Sexual Selection Influences Demography Under Recurrent Heatwaves
Porwal, N.; Parrett, J. M.; Kruszynska, A. S.; Pandey, N.; Knell, R. J.; Cameron, T. C.; Radwan, J.
10.1101/2025.03.31.646346 — evolutionary biology — Posted on 2025-04-02
4968 Impacts on the microbial fungal communities across water, sediment, and amphibian hosts across an urbanization gradient waterway in Worcester, Massachusetts
Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.
10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-02
4970 Ultrasound-based prediction of spawning time in females of Octopus vulgaris
Marquez, L.; Weterings, P.; Saber, S.; Felipe, B. C.; Maccuro, S.; Serrano, M.; Seuntjens, E.; Acosta-Cifuentes, F.; Gonzalez, M.; Almansa, E.
10.1101/2025.03.28.645890 — zoology — Posted on 2025-04-02
4971 Two opposing redox signals mediated by 2-Cys peroxiredoxin shape the redox proteome during photosynthetic induction
Doron, S.; Lampl, N.; Savidor, A.; Pri-Or, A.; Katina, C.; Cejudo, F. J.; Levin, Y.; Rosenwasser, S.
10.1101/2025.04.02.646757 — plant biology — Posted on 2025-04-02
4973 Attention Guided Mechanism Interpretable Drug-Gene Interaction (MIDI) Modeling for Cancer Drug Response Prediction and Target Effect Explanation
Wanyan, T.; Cai, L.; Nijhawan, D.; Posner, B.; Kim, J.; Yuan, R.; Wang, R.; Huang, J.; Yang, S.; Mallipeddi, P.; Wang, T.; Zhan, X.; Xiao, G.; Xie, Y.
10.1101/2025.03.31.646490 — cancer biology — Posted on 2025-04-02
4974 Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype
Perry, R. N.; Lenert, G.; Benavente, E. D.; Ma, A.; Barbera, N.; Mokry, M.; de Kleijn, D. P.; de Winther, M. P.; Mayr, M.; Bjorkegren, J. H.; den Ruijter, H. H.; Civelek, M.
10.1101/2025.03.28.645955 — genomics — Posted on 2025-04-02
4976 Unfolding admixed ancestry and genomic diversity in zoo giraffes
Fraser, M. F.; Heller, R.; Bertola, L. D.; Hvilsom, C.; Balboa, R. F.; Liu, X.; Bruniche-Olsen, A.
10.1101/2025.03.31.645993 — evolutionary biology — Posted on 2025-04-02
4979 Contrasting amphibian population trend from a protected area in Madagascar reveal severe underestimation of extinction risks
Porcel, X.; Crottini, A.; Freeman, K.; Noel, J.; Velo, J. H.; Lava, H.; Rendrirendry, G.; Andreone, F.; Dubos, N.
10.1101/2025.03.28.645942 — ecology — Posted on 2025-04-02
4980 CRISPR/Cas9-mediated generation of two isogenic CEP290-mutated iPSC lines
Figueiro-Silva, J.; Eschment, M.; Mennel, M.; Abidi, A.; Oneda, B.; Rauch, A.; Bachmann-Gagescu, R.
10.1101/2025.03.31.646311 — developmental biology — Posted on 2025-04-02
4981 Single Nucleus Multiome Analysis Reveals Early Inflammatory Response to High-Fat Diet in Mouse Pancreatic Islets
Ernst, I. V. S.; Lehtonen, L.; Nilsson, S. M.; Nielsen, F. L.; Marcher, A.-B.; Mandrup, S.; Madsen, J. G. S.
10.1101/2025.04.01.646568 — cell biology — Posted on 2025-04-02
4982 KIF20A cooperates with Myosin II to drive endosomal carriers fission and protein trafficking
Selot, J.; Lasbareilles, S.; Colasse, S.; Miserey, S.; Delevoye, C.; Thepot, J. S.; Karaiskou, A.
10.1101/2025.04.01.646333 — cell biology — Posted on 2025-04-02
4988 Homeostatic Activation of 26S Proteasomes by Protein Kinase A Protects against Cardiac and Neurobehavior Malfunction in Alzheimer's Disease Mice
Chakroborty, A.; Ejaz, S.; Sternburg, J. O.; Asadi, Y.; Cai, M.; Dwamena, A. A.; Giri, S.; Adeniji, O.; Ahammed, M. S.; Gilstrap, E. A.; Uddin, M. G.; McDowell, C.; Liu, J.; Wang, H.; Wang, X.
10.1101/2025.03.28.645869 — physiology — Posted on 2025-04-02
4989 DEVELOPMENT OF PROTOCOLS FOR DEPOSITING A RARE PLANT SPECIES OF THE ROSTOV REGION, THYMUS CALCAREUS KLOKOV & DES. SHOST.
Chokheli, V. A.; Tulupov, K. A.; Azarov, A. S.; Belyaev, M. O.; Tsymerskaia, C. A.; Sushkova, S. N.
10.1101/2025.03.31.646457 — physiology — Posted on 2025-04-02
4990 Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer
Jin, N.; Hoyd, R.; Yilmaz, A. S.; Zhu, J.; Liu, Y.; Singh, M. J.; Grencewicz, D.; Mo, X.; Kalady, M.; Rosenberg, D.; Dravillas, C. E.; Singer, E. A.; Carpten, J. D.; Chan, C. H.; Churchman, M. L.; Denko, N. C.; Di Clemente, F.; Dodd, R. D.; Eljilany, I.; Fei, N.; Hardikar, S.; Ikeguchi, A. P.; Ma, A.; Ma, Q.; McCarter, M. D.; Osman, A. E.; Riedlinger, G.; Robinson, L. A.; Schneider, B. P.; Tarhini, A. A.; Tinoco, G.; Figueiredo, J.; Zakharia, Y.; Ulrich, C. M.; Tan, A. C.; Spakowicz, D.
10.1101/2025.03.28.645992 — cancer biology — Posted on 2025-04-02
4992 Protocol for Extracting Circulating Cell-Free DNA from Murine Saliva: Insights into Oral and Systemic Disease Research
Elamin, I.; Rao, M. S.; Figliozzi, R. W.; Maahs, J. C.; Balish, M.; Hsia, S. V.; Fugolin, A. P. P.; Fan, J.
10.1101/2025.03.31.645839 — genomics — Posted on 2025-04-02
4996 Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection
Deruelle, V.; Dupuis, G.; Raoux-Barbot, D.; Lim, E.; Ponce-Lopez, R.; Ladant, D.; Renault, L.; Mechold, U.
10.1101/2025.03.26.645418 — microbiology — Posted on 2025-04-02
4997 Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia
Yohida, T.; Sugino, H.; Yamamoto, H.; Tanno, S.; Tamura, M.; Igarashi, J.; Isomura, Y.; Hira, R.
10.1101/2024.07.12.603330 — neuroscience — Posted on 2025-04-02
4998 On variability in local field potentials
Parto-Dezfouli, M.; Johnson, E. L.; Psarou, E.; Bosman, C. A.; Krishna, B. S.; Fries, P.
10.1101/2025.03.27.645661 — neuroscience — Posted on 2025-04-02
4999 DEVELOPMENT OF PROTOCOLS FOR THE CULTIVATION OF WORMWOOD (ARTEMISIA SALSOLOIDES)
Chokheli, V. A.; Azarov, A. S.; Petrenko, V. S.; Belyaev, M. O.; Tulupov, K. A.; Tsymerskaia, C. A.; Sushkova, S. N.
10.1101/2025.03.31.646446 — physiology — Posted on 2025-04-02
5000 Selective targeting of oncogenic KRAS G12D using peptide nucleic acid oligomers attached to cell-penetrating peptides
Mondal, J.; Lam, D.; Gerritsen, M. E.; Brotz, T. M.; Kennedy, J. G.; Rehlaender, B.; Ross, A. J.; Levy, D. E.; Bonagura, C. A.; Lanzilotta, W. N.; McCormick, F.; Rothman, J. H.; Wolfe, A. L.
10.1101/2025.03.28.645837 — cancer biology — Posted on 2025-04-02
5003 Learning multi-cellular representations of single-cell transcriptomics data enables characterization of patient-level disease states
Liu, T.; De Brouwer, E.; Kuo, T.; Diamant, N.; Missarova, A.; Wang, H.; Hao, M.; Biancalani, T.; Bravo, H. C.; Scalia, G.; Regev, A.; Heimberg, G.
10.1101/2024.11.18.624166 — bioinformatics — Posted on 2025-04-02
5005 Variations in kinase and effector signaling logic in a bacterial two component signaling network
Swingle, D.; Epstein, L.; Aymon, R.; Isiorho, E. A.; Abzalimov, R. R.; Favaro, D. C.; Gardner, K. H.
10.1101/2024.11.04.621962 — biochemistry — Posted on 2025-04-02
5006 Predicting the DNA binding specificity of transcription factor mutants usingfamily-level biophysically interpretable machine learning
Liu, S.; Gomez-Alcala, P.; Leemans, C.; Glassford, W. J.; Melo, L. A. N.; Lu, X.-J.; Mann, R. S.; Bussemaker, H. J.
10.1101/2024.01.24.577115 — genomics — Posted on 2025-04-02
5010 CCDC32 stabilizes clathrin-coated pits and drives their invagination
Yang, Z.; Yang, C.; Huang, Z.; Xu, P.; Li, Y.; Han, L.; Peng, L.; Wei, X.; Pak, J.; Svitkina, T.; Schmid, S. L.; Chen, Z.
10.1101/2024.06.26.600785 — cell biology — Posted on 2025-04-02
5011 Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides
Kabonick, S. G.; Verma, K.; Modesto, J. L.; Pearce, V. H.; Winokur, K. M.; Groisman, E. A.; Townsend, G. E.
10.1101/2024.11.13.623061 — microbiology — Posted on 2025-04-02
5012 A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Sullivan, A. E.; Nabhani, A.; Schinkel, K.; Dinh, D. M.; Duncan, M. L.; Ednacot, E. M. Q.; Hoffman, C. R. K.; Izrailevsky, D. S.; Kibby, E. M.; Nagy, T. A.; Nguyen, C. M.; Tak, U.; Burroughs, A. M.; Aravind, L.; Whiteley, A. T.; Morehouse, B. R.
10.1101/2025.03.28.646047 — microbiology — Posted on 2025-04-02
5013 Bone marrow mesenchymal stromal cells mediate cellular inflammation in HFpEF
Mentkowski, K.; Lee, I.-H.; Rohde, D.; Paccalet, A.; Seung, H.; Kumowski, N.; Schloss, M. J.; Carpenito-Kronenfeld, M.; Kaushal, V.; Jain, R.; Memcaj, X.; Wiebe, J.; Momin, N.; Pabel, S.; Muse, C. G.; Tuy, K.; Ung, S.; Roh, J.; Swirski, F. K.; Scadden, D.; van Galen, P.; Kreso, A.; Naxerova, K. N.; Hulsmans, M.; Nahrendorf, M.
10.1101/2025.03.28.645924 — immunology — Posted on 2025-04-02
5014 Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer
Gleba, J. J.; Siegler, E. L.; Manriquez-Roman, C.; DeFranco, G. E.; Huynh, T. N.; Mai, L. K.; Miller, J. L.; Miller, E. E.; Pawlush, M. L.; Alasonyalilar Demirer, A.; Kimball, B. L.; Tapper, E. E.; Sakemura, R. L.; Stewart, C. M.; Can, I.; Sirpilla, O. L.; Feigin, J. M.; Yun, K.; Gutierrez-Ruiz, O. L.; Xia, H.; Hefazi, M.; Schick, K. J.; Ogbodo, E. J.; Olivier, G.; Qiu, Y.; Tun, H. W.; Smallridge, R. C.; Zubair, A.; Copland, J. A.; Kenderian, S. S.
10.1101/2024.03.15.585286 — immunology — Posted on 2025-04-02
5020 ELF3 controls trait heterogeneity by tuning the rate of maturation in Arabidopsis and barley
McCarthy, K.; Pook, H.; Redmond, E. J.; Ronald, J.; Keir, J.; Zhu, Z.; Quint, M.; Davis, P. A.; Hartley, S. E.; Davis, S.; Ezer, D.
10.1101/2025.03.24.644900 — plant biology — Posted on 2025-04-02
5021 Semaglutide interferes with postnatal development of juvenile mice with compromised growth
Joly, A.; Rebiffe, L.; Dusabyinema, Y.; Dellinger, J.; Leulier, F.; De Vadder, F.
10.1101/2024.05.06.592704 — physiology — Posted on 2025-04-02
5022 Mapping cellular targets of covalent cancer drugs in the entire mammalian body
Pang, Z.; Leung, V. H.; Wang, C. C.; Attarpour, A.; Rinaldi, A.; Shen, H.; Glynn, C.; Sigua, L. H.; Yender, M.; Selke, A.; Xu, S.; Wu, P.; Goubran, M.; Cravatt, B. F.; Ye, L.
10.1101/2025.03.28.645991 — pharmacology and toxicology — Posted on 2025-04-02
5023 Dose- and time-dependent effects of cobalt protoporphyrin IX on granulocyte mobilization and metabolic markers in mice
Bednarz, A.; Kozuch, P.; Kowalski, K.; Skulimowska, I.; Kachamakova-Trojanowska, N.; Filipek-Gorzala, J.; Kwiecinska, P.; Garcia Garcia, R.; Gawlinska, K.; Malezyna, K.; Kubiak, A.; Bryniarska-Kubiak, N.; Jozkowicz, A.; Szade, K.; Szade, A.
10.1101/2024.10.22.619673 — pharmacology and toxicology — Posted on 2025-04-02
5024 Lack of consistent effect of dietary fiber on immune checkpoint blockade efficacy across diverse murine tumor models
Roichman, A.; Reyes-Castellanos, G.; Chen, Z.; Chen, Z.; Mitchell, S. J.; MacArthur, M. R.; Sawant, A.; Levett, L.; Powers, J.; Gomez, M.; Ibrahim, M.; Xu, X.; Tomlinson, B.; Hang, X.; Wei, Y.; Kang, Y.; White, E.; Rabinowitz, J. D.
10.1101/2025.03.28.645975 — cancer biology — Posted on 2025-04-02
5026 Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma
Mossi Albiach, A.; Janusauskas, J.; Kjaer Jacobsen, J.; Kapustova, I.; Karamzadeh, R.; Kvedaraite, E.; Hu, L.; Franck, M. C.; Mannens, C.; Codeluppi, S.; Munting, J. B.; Borm, L. E.; Shamikh, A.; Lonnerberg, P.; Siletti, K. A.; Persson, O.; Linnarsson, S.
10.1101/2023.09.01.555882 — cancer biology — Posted on 2025-04-02
5031 biscot: an Optimal Transport framework for multimodal bacterial single-cell data analysis
Feldl, M.; Abbaszade, G.; Schattenberg, F.; Stuckrath, K.; Mueller, S.; Mueller, C. L.
10.1101/2025.03.28.645895 — bioinformatics — Posted on 2025-04-02
5032 The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state
Balistreri, A.; Kolli, D.; Jayaweera, S. W.; Lundahl, D.; Han, Y.; Kalcec, L.; Goetzler, E.; Alessio, R.; Ruotolo, B.; Olofsson, A.; Chapman, M. R.
10.1101/2025.03.21.644623 — biochemistry — Posted on 2025-04-02
5033 Customizing the Structure of a Minimal TIM Barrel to Craft a De Novo Enzyme
Beck, J.; Smith, B. J.; Zarifi, N.; Freund, E.; Chica, R. A.; Hoecker, B.
10.1101/2025.01.28.635154 — biochemistry — Posted on 2025-04-02
5035 Bayesian analysis and efficient algorithms for single-molecule fluorescence data and step counting
Mattamira, C.; Ward, A.; Krishnan, S. T.; Lamichhane, R.; Barrera, F. N.; Sgouralis, I.
10.1101/2025.03.04.641510 — biochemistry — Posted on 2025-04-02
5036 Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3
Rowland, C. E.; Newman, H.; Martin, T. T.; Dods, R.; Bournakas, N.; Wagstaff, J. M.; Lewis, N.; Stanway, S. J.; Balmforth, M.; Kessler, C.; van Rietschoten, K.; Bellini, D.; Roper, D. I.; Lloyd, A. J.; Dowson, C. G.; Skynner, M. J.; Beswick, P.; Dawson, M. J.
10.1101/2024.03.20.581580 — biochemistry — Posted on 2025-04-02
5040 Adaptive challenges of past and future invasion of Drosophila suzukii: insights from novel genomic resources and statistical methods combining individual and pool sequencing data
Camus, L.; Rode, N. O.; Serga, S.; Loiseau, A.; Chen, X.; Iampietro, C.; Kenis, M.; Marande, W.; Mensch, J.; Parrinello, H.; Savic Veselinovic, M.; Valiere, S.; Zhang, J.; Estoup, A.; Boitard, S.; Gautier, M.
10.1101/2024.10.11.617812 — evolutionary biology — Posted on 2025-04-02
5041 Long-lasting coexistence of multiple asexual lineages alongside their sexual counterparts in a fungal plant pathogen
Abdalrahem, A.; Andrieux, A.; Becheler, R.; Duplessis, S.; Frey, P.; Marcais, B.; Stoeckel, S.; Halkett, F.
10.1101/2025.03.28.645883 — evolutionary biology — Posted on 2025-04-02
5042 Multiple bursts of speciation in Madagascar's endangered lemurs
Everson, K. M.; Pozzi, L.; Barrett, M. A.; Blair, M. E.; Donohue, M. E.; Kappeler, P. M.; Kitchener, A. C.; Lemmon, A. R.; Lemmon, E. M.; Pavon-Vazquez, C. J.; Radespiel, U.; Randrianambinina, B.; Rasoloarison, R. M.; Rasoloharijaona, S.; Roos, C.; Salmona, J.; Yoder, A. D.; Zenil-Ferguson, R.; Zinner, D.; Weisrock, D. W.
10.1101/2023.04.26.537867 — evolutionary biology — Posted on 2025-04-02
5043 Tracking the phenology of riverine insect communities using environmental DNA
Cereghetti, E.; Ajvazi, X.; Keck, F.; Patrignani, A.; Tartini, N.; Altermatt, F.; Carraro, L.
10.1101/2025.01.10.632357 — ecology — Posted on 2025-04-02
5044 Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle
Singh Yadav, A.; Hong, L.; Klees, P. M.; Kiss, A.; Petit, M.; He, X.; Barrios, I. M.; Heeney, M.; Galang, A. M. D.; Smith, R. S.; Boudaoud, A.; Roeder, A. H. K.
10.1101/2023.07.22.549953 — developmental biology — Posted on 2025-04-02
5046 Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport
Jones, E. M.; Camera, E.; Parzymies, P.; Marsh, S. T.; O'Shaughnessy, R. F.; Aumailley, M.; McGrath, J. A.; O'Toole, E. A.; Caley, M. P.
10.1101/2023.09.10.557030 — cell biology — Posted on 2025-04-02
5048 Diversity and varying predation capacities of Amoebozoa against opportunistic vibrios in contrasting Mediterranean coastal environments.
Robino, E.; Perret, A.; Noel, C.; Haffner, P.; Intertaglia, L.; Richard, M.; Descamps, N.; Sellier, A.; Onillon, L.; Lebaron, P.; Destoumieux-Garzon, D.; Charriere, G. M.
10.1101/2025.03.14.643055 — microbiology — Posted on 2025-04-02
5049 Impact of low-calorie sweeteners on gut bacteria is modulated by common xenobiotics
Blasche, S.; Periwal, V.; Covarrubias, N. B.; Lindell, A.; Roux, I.; Kamrad, S.; Bradley, R.; Guan, R.; Ozgur, H.; Ramachandran, B.; Benes, V.; Patil, K. R.
10.1101/2025.03.28.645995 — microbiology — Posted on 2025-04-02
5050 Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate
Li, H.; Ji, S.; Ariefta, N. R.; Galon, E. M. S.; El-Sayed, S. A.; Do, T.; Jia, L.; Sakaguchi, M.; Asada, M.; Nishikawa, Y.; Qin, X.; Liu, M.; Xuan, X.
10.1101/2024.07.15.603500 — microbiology — Posted on 2025-04-02
5051 Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense
Chai, C.; Sultan, E.; Sarkar, S. R.; Zhong, L.; Sarfati, D. N.; Gershoni-Yahalom, O.; Jacobs-Wagner, C.; Rosental, B.; Wang, B.
10.1101/2025.03.28.645876 — immunology — Posted on 2025-04-02
5052 Alternative splicing generates a Ribosomal Protein S24 isoform induced by neuroinflammation and neurodegeneration
Magadi, S. S.; Jonson, M.; Maqdissi, J. A.; Kaczmarczyk, L.; Zijlstra, J. J.; Perkins, M.; Paul, G.; Hallbeck, M.; Ingelsson, M.; Watts, J. C.; Reichenbach, N.; Petzold, G. C.; Lucena, P. B.; Heneka, M. T.; Jackson, W. S.
10.1101/2025.03.28.645676 — neuroscience — Posted on 2025-04-02
5053 A novel critic signal in identified midbrain dopaminergic neurons of mice training in operant tasks
Matsumoto, J.; Oberto, V.; Pompili, M. N.; Todorova, R.; Papaleo, F.; Nishijo, H.; Venance, L.; Vandecasteele, M.; Wiener, S. I.
10.1101/2024.05.06.592735 — neuroscience — Posted on 2025-04-02
5054 Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagy
Chica, N.; Andersen, A. N.; Orellana-Munoz, S.; Garcia, I.; Nguea P, A.; Nakken, S.; Ayuda-Duran, P.; Hakensbakken, L.; Schultz, S. W.; Rodningen, E.; Putnam, C. D.; Zucknick, M.; Rusten, T. E.; Enserink, J. M.
10.1101/2024.04.06.588104 — systems biology — Posted on 2025-04-02
5055 Repeated acoustic stimuli induce decentralized transcriptional memory for robust priming of plant defense.
Hadj-Amor, K.; Leger, O.; Raffaele, S.; Kovacic, M.; Duclos, A.; Carvalho-Silva, P.; Garcia, F.; Barbacci, A.
10.1101/2024.05.03.592392 — plant biology — Posted on 2025-04-02
5057 Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging
Howe, C. L.; Zhao, K. L. Y.; Verinaz-Jadan, H.; Song, P.; Barnes, S. J.; Dragotti, P. L.; Foust, A. J.
10.1101/2025.03.17.643718 — bioengineering — Posted on 2025-04-02
5059 A new genome assembly of the pea cultivar Cameor provides resources for functional genomics and genetics
Kreplak, J.; Novak, P.; Robledillo, L. A.; AUBERT, G.; Imbert, B.; Kaur, P.; Gouil, Q.; Lopez-Roques, C.; Rodde, N.; BOUCHEZ, O.; Tayeh, N.; Macas, J.; Burstin, J.
10.1101/2025.04.01.645976 — genomics — Posted on 2025-04-02
5061 The essential role of connective-tissue cells during axolotl limb regeneration
Garcia-Garcia, D.; Knapp, D.; Kim, M.; Jamwal, K.; Fuqua, H.; Seaman, R. P.; Grindle, R. E.; Nowoshilow, S.; Novatchkova, M.; Kolling, F. W.; Graber, J. H.; Murawala, P.
10.1101/2025.03.30.645595 — developmental biology — Posted on 2025-04-02
5063 REPOP: bacterial population quantification from platecounts
Pessoa, P.; Lu, C.; Tashev, S. A.; Kruithoff, R.; Shepherd, D. P.; Presse, S.
10.1101/2025.04.01.644179 — microbiology — Posted on 2025-04-02
5064 Cytomegalovirus-induced T cell responses accelerate Alzheimer's disease progression in mice
Marsden, M.; McLaren, J. E.; Bevan, R. J.; Penn-Ripley, D.; Somerville, M.; Lauder, S. N.; Gallimore, A.; Price, D. A.; Miners, K. L.; Ladell, K.; Siebzehnrubl, F. A.; Hughes, T. R.; Humphreys, I. R.; Clement, M.
10.1101/2025.03.28.645902 — immunology — Posted on 2025-04-02
5065 Olfactory dysfunction in a novel model of prodromal Parkinson's disease in adult zebrafish
Vorhees, N. W.; Groenwold, S. L.; Williams, M. T.; Putt, L. S.; Sanchez-Gama, N.; Stalions, G. A.; Taylor, G. M.; Van Dort, H. E.; Calvo-Ochoa, E.
10.1101/2025.03.29.645796 — neuroscience — Posted on 2025-04-02
5067 Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations
Rampy, J.; Torres-Manzo, A. P.; Hoffsmith, K.; Loberg, M. A.; Sheng, Q.; Salas-Lucia, F.; Bianco, A. C.; Arrojo e Drigo, R.; Wang, H.; Weiss, V. L.; Carrasco, N.
10.1101/2025.03.31.645596 — physiology — Posted on 2025-04-02
5069 Cell and nuclear size are associated with chromosomal instability and tumorigenicity in cancer cells that undergo whole genome doubling
Bloomfield, M.; Huth, S.; McCausland, D.; Saad, R.; Bano, N.; Chau, T. N.; Sweet, M.; Baudoin, N. C.; McCaffrey, A.; Fluet, K.; Schmelz, E. M.; Ben-David, U.; Cimini, D.
10.1101/2025.03.28.645986 — cancer biology — Posted on 2025-04-02
5070 Loss-of-Function genetic Screen Unveils Synergistic Efficacy of PARG Inhibition with Combined 5-Fluorouracil and Irinotecan Treatment in Colorectal Cancer
Queralt, C.; Moreta-Moraleda, C.; Costa, M.; Grau-Leal, F.; Diesch, J.; Vendrell-Ayats, C.; Musulen, E.; Buges, C.; Manzano, J. L.; Cabrero, S.; Zuber, J.; Buschbeck, M.; Forcales, S.-V.; Martinez-Balibrea, E.
10.1101/2025.03.29.644889 — cancer biology — Posted on 2025-04-02
5071 Generative Landscapes and Dynamics to Design Multidomain Artificial Transmembrane Transporters
Ortega, F. M.; Hossain, F.; Volobouev, V. V.; Meloni, G.; Torabifard, H.; Morcos, F.
10.1101/2025.03.28.645293 — biophysics — Posted on 2025-04-02
5074 Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging
Clark, I. H.; Heinmiller, A.; Zhu, W.; Zhu, X.-H.; Strell, P.; Roushdy, Z.; Vernekar, M.; Johnson, S.; Natera, D.; Sun, K.; Wiesner, H.; Haney, K.; Grande, A. w.; Low, W. C.; Chen, W.
10.1101/2025.03.31.645325 — bioengineering — Posted on 2025-04-02
5076 A canonical cortical electronic circuit for neuromorphic intelligence
Maryada, ; De Luca, C.; Rubino, A.; Wen, C.; Cartiglia, M.; Fodorut, I.-I.; Payvand, M.; Indiveri, G.
10.1101/2025.03.28.646019 — neuroscience — Posted on 2025-04-01
5078 Released mitochondrial DNA and neurofilament light chain as Parkinson's disease phenotypes in patient-specific midbrain assembloids
Sabate-Soler, S.; Rosety, I.; Gomez-Giro, G.; Ghelfi, J.; Hezzaz, S.; Grunewald, A.; Schwamborn, J. C.; Jarazo, J.
10.1101/2025.03.28.645921 — neuroscience — Posted on 2025-04-02
5079 The developing retina undergoes mitochondrial remodeling via PINK1/PRKN-dependent mitophagy
Zapata-Munoz, J.; Jimenez-Loygorri, J. I.; Stumpe, M.; VILLAREJO ZORI, B.; Boya, P.; Alonso-Gil, S.; Teresak, P.; Mathai, B. J.; Ganley, I. G.; Simonsen, A.; Dengjel, J.
10.1101/2025.03.30.646079 — developmental biology — Posted on 2025-04-01
5082 Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder
Meyer, K.; Woodworth, M.; Goncalves, M. C. B.; Yue, M.; AlJandal, H.; Morton, S.; Lewandowski, M.; Liu, N.; Zigon, E.; Fortuna, P.; Garcia-Corral, M.; Budnik, B.; Church, G. M.; Tam, J. M.
10.1101/2025.04.01.646642 — cell biology — Posted on 2025-04-01
5084 Deep learning recognises antibiotic modes of action from brightfield images
Krentzel, D.; Kho, K.; Petit, J.; Mahtal, N.; Shorte, S. L.; Wehenkel, A. M.; Boneca, I. G.; Zimmer, C.
10.1101/2025.03.30.645928 — microbiology — Posted on 2025-04-01
5085 Reduced gravity and muon radiation affect Caenorhabditis elegans life history traits and viral infection
Villena-Gimenez, A.; Castiglioni, V. G.; Legarda, E. G.; Munoz-Sanchez, J. C.; Gonzalez, R.; Elena, S. F.
10.1101/2024.10.03.616447 — microbiology — Posted on 2025-04-01
5086 Interpretable Inflammation Landscape of Circulating Immune cells
Jimenez-Gracia, L.; Maspero, D.; Aguilar-Fernandez, S.; Craighero, F.; Boulougouri, M.; Ruiz, M.; Marchese, D.; Caratu, G.; Linares-Blanco, J.; Berasategi, M.; Ramirez Flores, R. O.; Sanzo-Machuca, A.; M. Corraliza, A.; A. Tran, H.; Normand, R.; Nestor, J.; Hong, Y.; Kole, T.; van der Velde, P.; Alleblas, F.; Pedretti, F.; Aterido, A.; Banchero, M.; Soriano, G.; Roman, E.; van den Berge, M.; Salas, A.; Carrascosa, J. M.; Fernandez Nebro, A.; Domenech, E.; Canete, J.; Tornero, J.; P. Gisbert, J.; Choy, E.; Girolomoni, G.; Siegmund, B.; Julia, A.; Serra, V.; Elosua, R.; Tejpar, S.; Vidal, S.; Na
10.1101/2023.11.28.568839 — immunology — Posted on 2025-04-01
5087 Decoding the Human Brain during Intelligence Testing
Thiele, J. A.; Faskowitz, J.; Sporns, O.; Chuderski, A.; Jung, R.; Hilger, K.
10.1101/2025.04.01.646660 — neuroscience — Posted on 2025-04-01
5094 Cognitive reserve linked to network-specificbrain-ventricle coupling
Campo, F. F.; Brattico, E.; Miguel, V.; Magalhaes, V.; Nigro, S.; Tafuri, B.; the Alzheimer's Disease Neuroimaging Initiative, ; Logroscino, G.; Cabral, J.
10.1101/2025.01.04.631289 — neuroscience — Posted on 2025-04-01
5095 B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2
Li, Q.; Wang, L.; Grubb, L. E.; Talasila, M.; Rodriguez Gallo, M. C.; Mehta, D.; Scandola, S.; Uhrig, R. G.
10.1101/2024.06.12.598286 — plant biology — Posted on 2025-04-01
5096 BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma
Xing, Y. L.; Panovska, D.; Park, J.-W.; Grossauer, S.; Koeck, K.; Bui, B.; Nasajpour, E.; Nirschl, J. J.; Feng, Z.-P.; Cheung, P.; Habib, P.; Wei, R.; Wang, J.; Thomason, W.; Xiu, J.; Beck, A.; Weber, K.; Harter, P. N.; Lim, M.; Mahaney, K.; Prolo, L. M.; Grant, G. A.; Ji, X.; Walsh, K. M.; Mulcahy Levy, J. M.; Hambardzumyan, D.; Petritsch, C. K.
10.1101/2023.02.03.526065 — cancer biology — Posted on 2025-04-01
5097 A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway
Doherty, E. E.; Adler, B. A.; Yoon, P. H.; Hsieh, K.; Loi, K.; Armbruster, E. G.; Lahiri, A.; Bolling, C. S.; Wilcox, X. E.; Akkati, A.; Iavarone, A. T.; Pogliano, J.; Doudna, J. A.
10.1101/2025.03.28.646030 — biochemistry — Posted on 2025-04-01
5102 Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
Marocco, F.; Garbo, S.; Montaldo, C.; Colantoni, A.; Quattrocchi, L.; Gaboardi, G.; Sabarese, G.; Cicchini, C.; Lecce, M.; Carnevale, A.; Paolini, R.; Tartaglia, G. G.; Battistelli, C.; Tripodi, M.
10.1101/2024.11.15.623754 — molecular biology — Posted on 2025-04-01
5103 Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose
Stewart, A.; Li, J.; Lee, M.; Lewis, J. M.; Herisse, M.; Hofferek, V.; McConville, M. J.; Pidot, S. J.; Scott, N. E.; Williams, S. J.
10.1101/2023.08.01.551581 — microbiology — Posted on 2025-04-01
5104 Combining a rhesus cytomegalovirus/SIV vaccine with neutralizing antibody to protect against SIV challenge in rhesus macaques
Coppola, J.; Parren, M.; Bastidas, R.; Saye-Francisco, K.; Malvin, J.; Jardine, J. G.; Gilbride, R. M.; Ojha, S.; Feltham, S.; Morrow, D.; Barber-Axthelm, A.; Bochart, R.; Fast, R.; Oswald, K.; Shoemaker, R.; Lifson, J. D.; Picker, L. J.; Burton, D. R.; Hansen, S. G.
10.1101/2025.03.20.644395 — immunology — Posted on 2025-04-01
5105 Synaptopathy in the TDP43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis
Ayvazian-Hancock, A.; Butler, E.; Meehan, C. F.; Miles, G. B.; Broadhead, M. J.
10.1101/2025.03.25.645173 — neuroscience — Posted on 2025-04-01
5110 Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula
Batzenschlager, M.; Lace, B.; Zhang, N.; Su, C.; Boiger, A.; Egli, S.; Krohn, P.; Salfeld, J.; Ditengou, F. A.; Laux, T.; Ott, T.
10.1101/2023.03.28.534635 — plant biology — Posted on 2025-04-01
5113 Optical sectioning for reflection interference microscopy
Ventalon, C.; Kirichuk, O.; Navon, Y.; Chastagnier, Y.; Heux, L.; Richter, R. P.; Bureau, L.; Debarre, D.
10.1101/2024.06.07.598038 — biophysics — Posted on 2025-04-01
5114 Enhancing CAR-T cell activity prediction via fine-tuning protein language models with generated CAR sequences
Yoshida, K.; Hisada, S.; Takase, R.; Okuma, A.; Ishida, Y.; Kawara, T.; Miura-Yamashita, T.; Ito, D.
10.1101/2025.03.27.645831 — bioinformatics — Posted on 2025-04-01
5117 Crystal structures of forty- and seventy-one-substitution variants of hydroxynitrile lyase from rubber tree
Pierce, C. T.; Tan, P.; Greenberg, L. R.; Walsh, M. E.; Shi, K.; Nguyen, A.; Meixner, E. L.; Sarak, S.; Aihara, H.; Evans, R. L.; Kazlauskas, R. J.
10.1101/2025.03.30.646168 — biochemistry — Posted on 2025-04-01
5119 Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences
Miedlar, E.; Hamilton, G. E.; Witus, S. R.; Gonske, S. J.; Riffle, M.; Zelter, A.; Klevit, R. E.; Asbury, C. L.; Dimitrova, Y. N.; Davis, T. N.
10.1101/2024.11.13.623448 — biochemistry — Posted on 2025-04-01
5120 Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Liu, J.; Shah, A.; Liu, X.; Wort, J. L.; Ma, Y.; Hardman, K.; Johansson, N. G.; De Castro Ribeiro, O. M.; Brookfield, A.; Bowen, A.; Yli-Kauhaluoma, J.; Xhaard, H.; Jeuken, L.; Goldman, A.; Pliotas, C.; Vidilaseris, K.
10.1101/2024.07.26.605302 — biochemistry — Posted on 2025-04-01
5121 Decoding sequence determinants of gene expression in diverse cellular and disease states
Lal, A.; Karollus, A.; Gunsalus, L.; Garfield, D.; Nair, S.; Tseng, A. M.; Gordon, M. G.; Blischak, J. D.; Van de Geijn, B.; Bhangale, T.; Collier, J. L.; Diamant, N.; Biancalani, T.; Corrada Bravo, H.; Scalia, G.; Eraslan, G.
10.1101/2024.10.09.617507 — genomics — Posted on 2025-04-01
5122 A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species
Chrysostomakis, I.; Mozer, A.; Bruno Di-Nizo, C.; Fischer, D.; Sargheini, N.; von der Mark, L.; Huettel, B.; Astrin, J. J.; Toepfer, T.; Boehne, A.
10.1101/2025.01.22.633903 — genomics — Posted on 2025-04-01
5123 Zombie Gene Flow: Asexual Hybrids Mediate Extensive Genomic Introgression from Extinct Species Into Their Sexual Parent
Vukic, J.; Marta, A.; Matura, F.; Kulik, D.; Eisner, J.; Sanda, R.; Tichopad, T.; Choleva, L.; Perdices, A.; Roslein, J.; Koci, J.; Shumka, S.; Ulqini, D.; Kotusz, J.; Dedukh, D.; Janko, K.
10.1101/2025.03.28.645731 — evolutionary biology — Posted on 2025-04-01
5126 Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Hanna, J.; Touahri, Y.; Pak, A.; Belfiore, L.; van Oosten, E.; David, L. A.; Han, S.; Ilnytskyy, Y.; Kovalchuk, I.; Kurrasch, D.; Okawa, S.; del Sol, A.; Screaton, R. A.; Aubert, I.; Schuurmans, C.
10.1101/2024.07.12.603298 — developmental biology — Posted on 2025-04-01
5127 Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona
Hozumi, A.; Totsuka, N. M.; Onodera, A.; Wang, Y.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Hotta, K.; Sasakura, Y.
10.1101/2024.04.09.588679 — developmental biology — Posted on 2025-04-01
5132 In-vivo Efficacy of a Phage Cocktail Therapy that Targets ESBL-producing Klebsiella Urinary Tract Infections Clinical Isolates
Jariah, R. O. A.; Schofield, J.; West, K.; Michniewski, S.; Jameson, E.; Onions, L.; Saravanan, A.; Yesilkaya, H.; Millard, A. D.; Clokie, M. R. J.; Haines, M. E. K.
10.1101/2025.04.01.646603 — microbiology — Posted on 2025-04-01
5133 SNX-BAR proteins 5 and 6 are required for NCOA7-AS antiviral activity against influenza A virus
Arnaud-Arnould, M.; Rebendenne, A.; Tauziet, M.; Urbach, S.; El Koulali, K.; Ricci, E. P.; Wencker, M.; Moncorge, O.; Blaise, M.; Goujon, C.
10.1101/2025.04.01.646557 — microbiology — Posted on 2025-04-01
5135 Odoribacter splanchnicus mitigates Salmonella-induced gut inflammation and its associated pathogenesis via its secreted bacteriocin
Hajra, D.; Mukherjee, D.; Vij, R.; Rajmani, R. S.; Dadireddy, V.; Das, D.; Hussain, T.; Ganji, M.; Tatu, U.; Chakravortty, D.
10.1101/2024.08.23.609322 — microbiology — Posted on 2025-04-01
5137 CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue
Liu, F.; Shi, H.; Turner, J. D.; Anscombe, R.; Sekine, T.; Hammitzsch, A.; Agarwal, D.; Mahony, C.; Chen, J.; Kendrick, B.; Du, D.; Tong, Q.; Duan, L.; Dooley, K.; Fang, H.; Korsunsky, I.; Madhu, R.; Cribbs, A.; consortium, C.; Friedrich, M.; Marsden, B. D.; Chen, Y.-L.; Ogg, G.; Adams, A.; Chen, W.; Leonardo, S.; McCann, F. E.; Buckley, C.; Rooney, T.; Freeman, T.; Uhlig, H. H.; Dendrou, C.; Croft, A.; Filer, A.; Bowness, P.; Chen, L.
10.1101/2024.10.11.617865 — immunology — Posted on 2025-04-01
5139 Adaptive learning via BG-thalamo-cortical circuitry
He, Q.; Scott, D. N.; Frank, M. J.; Calderon, C. B.; Nassar, M. R.
10.1101/2025.03.13.643078 — neuroscience — Posted on 2025-04-01
5141 Exercise Evokes Retained Motor Performance without Neuroprotection in a Mouse Model of Parkinson's Disease
Skelton, H. M.; Hyman, N.; Fernandez, A.; Acerbo, E.; Scott, M.; Berglund, K.; Gutekunst, C.-A.; Gross, R. E.
10.1101/2024.09.20.614034 — neuroscience — Posted on 2025-04-01
5142 Relevance of Nonlinear Dimensionality Reduction for Efficient and Robust Spike Sorting
Suarez-Barrera, D.; Bayones, L.; Parra, S.; Monroy, V.; Pujalte, S.; Andrade-Ortega, B.; Diaz, H.; Alvarez, M.; Zainos, A.; Franci, A.; Rossi-Pool, R.
10.1101/2025.03.27.645844 — neuroscience — Posted on 2025-04-01
5143 Tau-Associated Neuronal Loss in the Intermediate Nucleus of the Human Hypothalamus (VLPO Analog): Unveiling the Basis of NREM Sleep Dysfunction in PSP and Alzheimer's Disease
Rastegar-Pouyani, S.; Lew, C.; Pereira, F.; Satpati, A.; Paes, V.; Leite, R. P.; Suemoto, C.; Spina, S.; Seeley, W. W.; Heinsen, H.; Walsh, C.; Neylan, T.; Grinberg, L. T.
10.1101/2025.03.11.642707 — neuroscience — Posted on 2025-04-01
5144 Working memory readout varies with frontal theta rhythms
Han, H.-B.; Brincat, S. L.; Buschman, T. J.; Miller, E. K.
10.1101/2025.03.27.645781 — neuroscience — Posted on 2025-04-01
5147 The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling
Zhao, Y.; Mi, C.; Wagner, J.; Jiang, W.; Poege, M.; Saha, I.; Xu, P.; Plitzko, J.; Guo, Q.; Beck, F.; Baumeister, W.
10.1101/2025.04.01.646186 — biochemistry — Posted on 2025-04-01
5149 Direct Amide Bond Formation By A Spore Peptidoglycan Biosynthetic Enzyme
Hopkins, M. E.; Yasinov, Z.; Fakler, M. J.; Wilde, G. E.; Wetmore, K. G.; Welsh, M. A.
10.1101/2025.03.28.644612 — biochemistry — Posted on 2025-04-01
5155 Assessing climate change impacts for small-scale fisheries in the Gulf of California using Deep Learning
Cavieses-Nunez, R.; Lu, Q.; Morzaria-Luna, H. N.; Mallick, P.; Kumara, S.; Navarrete-Torices, C. R.; Cruz-Pinon, G.; Buechler, S.; Lopez-Olmedo, K.
10.1101/2025.03.28.645356 — ecology — Posted on 2025-04-01
5156 SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the aging mouse testis
Guitart-Solanes, A.; Romero, M.; Fernanadez-Duran, I.; Niedenberger, B. A.; Madrid-Sandin, C.; Roig, I.; Geyer, C. B.; Vaquero, A.; Schindler, K.; Vazquez, B. N.
10.1101/2025.03.31.645534 — cell biology — Posted on 2025-04-01
5158 A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival
Neophytou, K.; Martinez-Ugalde, I.; Fenton, T.; Robertson, E.; Strachan, L. J.; Harcus, Y.; Naar, C. M.; Wright, D.; Price, D. R. G.; White, R.; Evans, M. J.; Bermudez-Barrientos, J. R.; Li, H.; Maizels, R. M.; Aroian, R. V.; Nisbet, A. J.; Abreu-Goodger, C.; Buck, A. H.
10.1101/2025.04.01.646544 — molecular biology — Posted on 2025-04-01
5160 Active Learning for Protein Structure Prediction
Xue, Z.; Bailey, M.; Gupta, A.; Li, R.; Corrochano-Navarro, A.; Li, S.; Kogler-Anele, L.; Yu, Q.; Bar-Joseph, Z.; Dr. Jager, S.
10.1101/2025.04.01.646404 — molecular biology — Posted on 2025-04-01
5162 Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA
Paul, T.; Lee, I.-R.; Pangeni, S.; Rashid, F.; Yang, O.; Antony, E.; Berger, J. M.; Myong, S.; Ha, T.
10.1101/2025.04.01.643995 — molecular biology — Posted on 2025-04-01
5163 Dairy cattle herds mount a characteristic antibody response to highly pathogenic H5N1 avian influenza viruses
Robinson-McCarthy, L. R.; Simmons, H. C.; Graber, A. L.; Marble, C. N.; Graudin, G. W.; McCarthy, K. R.
10.1101/2025.04.01.646587 — microbiology — Posted on 2025-04-01
5164 Multi-locus phylogenetic network analysis of Ampelomyces mycoparasites isolated from diverse powdery mildews in Australia and the generation of two de novo genome assemblies
Goldspink, L.; Sotiropoulos, A. G.; Idnurm, A.; Ash, G. J.; Dearnaley, J. D. W.; Boddington, M.; Ahmad, A.; Nemeth, M. Z.; Pintye, A.; Gorfer, M.; Shin, H.-D.; Kovacs, G. M.; Vaghefi, N.; Kiss, L.
10.1101/2025.03.31.646484 — microbiology — Posted on 2025-04-01
5166 High-resolution Staphylococcus profiling reveals intra-species diversity in a single skin niche
Herman, R.; West, D. T.; Meaden, S.; Khan, I.; Cornmell, R.; Hunt, J.; Rudden, M.; Wilkinson, H. N.; Hardman, M. J.; Wilkinson, A. J.; Murphy, B.; Thomas, G. H.
10.1101/2025.04.01.646391 — microbiology — Posted on 2025-04-01
5167 Ketamine inhibition of SARS-CoV-2 replication in astrocytes is associated with COVID-19 disease severity in a variant-dependent manner
Furlani, B.; Potokar, M.; Korva, M.; Resman Rus, K.; Pozvek, P.; Zorec, T. M.; Vrsnik, J.; Pirnat, S.; Tavcar Verdev, P.; Smolic, T.; Horvat, A.; Radinovic, K.; Graselli Kmet, N.; Avsic-Zupanc, T.; Vardjan, N.; Stenovec, M.; Jereb, M.; Jorgacevski, J.; Zorec, R.
10.1101/2025.03.29.646083 — neuroscience — Posted on 2025-04-01
5168 MiR-126 Improves the Therapeutic Effect of EPC in Hypertensive Ischemic Stroke
Huang, J.; Zhao, B.; Li, X.; Ding, l.; Fu, M.; Song, Y.; Qu, M.; Chen, D.; Yang, G.-Y.; Gao, P.-J.
10.1101/2025.03.27.645845 — neuroscience — Posted on 2025-04-01
5170 Transient volume stabilization reveals the key role a PM permeability in pyroptotic cell swelling.
Bastien, E.; Duprez, G.; Delanoë-Ayari, H.; Riviere, C.; Petrilli, V.; Recho, P.; Monnier, S.
10.1101/2025.03.27.645729 — biophysics — Posted on 2025-04-01
5171 Structural defects in amyloid-β fibrils drive secondary nucleation
Hu, J.; Scheidt, T. J.; Thacker, D.; Axell, E.; Stemme, E.; Lapinska, U.; Wennmalm, S.; Meisl, G.; Curk, S.; Andreasen, M.; Vendruscolo, M.; Arosio, P.; Saric, A.; Schmit, J.; Knowles, T.; Sparr, E.; Linse, S.; Michaels, T. C. T.; Dear, A. J.
10.1101/2025.03.31.646415 — biophysics — Posted on 2025-04-01
5174 DeNoFo: a file format and toolkit for standardised, comparable de novo gene annotation
Dohmen, E.; Aubel, M.; Eicholt, L. A.; Roginski, P.; Luria, V.; Karger, A.; Grandchamp, A.
10.1101/2025.03.31.644673 — bioinformatics — Posted on 2025-04-01
5175 Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses
Faria Fonseca, B.; Wong-Ng, J.; Connor, M.; Mary, H.; Kim, M. H.; Yim, R.; BONDET, V.; Michel, V.; Strick Marchand, H.; Di Santo, J. P.; Duffy, D.; Hamon, M. A.; Sauvonnet, N.; Chakrabarti, L. A.; Gobaa, S.
10.1101/2025.03.31.644992 — bioengineering — Posted on 2025-04-01
5180 Despotism promotes cooperation through enhanced interdependencies in non-human primate societies
Bhattacharjee, D.; Zijlstra, T. W.; Roth, T. S.; Belli, E.; Calis, S. E.; Chova, P. E.; Cousin, E.; de Jong, J. A.; de Laat, E.; Gudjonsdottir, A. R.; Janmaat, K. R. L.; Jeunink, E. J.; Kluiver, C. E.; Kuijer, P. E. N.; Middelburg, E.; Pfluger, L. S.; Schroderus, V. I.; van Dijk, E. S. J.; Verspeek, J.; Waasdorp, S.; Zeeman, A. N.; Sterck, E. H. M.; van Leeuwen, E. J. C.; Massen, J. J. M.
10.1101/2025.03.27.645840 — animal behavior and cognition — Posted on 2025-04-01
5181 Global Metagenomics Reveals Plastid Diversity and Unexplored Algal Lineages
Shrestha, B.; Romero, M. F.; Villada, J. C.; Plastid MAG Consortium, ; Blaby-Haas, C. E.; Schulz, F.
10.1101/2025.03.28.644651 — evolutionary biology — Posted on 2025-04-01
5184 Zone Matcher: A climate-based web application for deployment and assisted migration of forest trees
Shalev, T. J.; McClure, M. L.; Stevenson-Molnar, N.; O'Neill, G. A.; Wang, T.; Stewart, J. A.; Howe, G. T.
10.1101/2025.03.30.644615 — ecology — Posted on 2025-04-01
5185 A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding
Hess, S.; Campos-Alonso, M.; Brand, M.; Lauw, S.; Lindenmann, U.; Goebel, K.; Geurink, P. P.; Fritz, G.; Riedl, R.; Knobeloch, K.-P.
10.1101/2025.03.30.646166 — molecular biology — Posted on 2025-04-01
5188 Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease
Mebus, V. H.; Busch, L. M.; Boerre, M.; Nielsen, T. K.; Bojer, M. S.; Henriksen, C.; Barbuti, M. D.; Angeles, D. M.; Brejndal, K.; Michalik, S.; Salazar, M. G.; Kjos, M.; Voelker, U.; Kallipolitis, B. H.; Frees, D.
10.1101/2025.04.01.646552 — microbiology — Posted on 2025-04-01
5189 Rapid Detection of Carbapenemase-Producing Organisms Using a Luminescent Biosensor
Jeffs, M. A.; Bhat, S.; Liu, J. L.; Gray, R. A.; Li, X. X.; Sheth, P. M.; Lohans, C. T.
10.1101/2025.04.01.646590 — microbiology — Posted on 2025-04-01
5190 Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter
Mehboob, J.; Herman, R.; Wilkinson, A. J.; Kinniment-Williams, B. E.; Elston, R. C.; Afolabi, H.; Van der Woude, M. W.; Thomas, G. H.
10.1101/2025.04.01.646390 — microbiology — Posted on 2025-04-01
5191 Impact of acetate on CO2 fixation pathways in thermophilic and hydrogenotrophic bacteria
Chiba, Y.; Sumida, T.; Kameya, M.; Fukuyama, Y.; Wakashima, T.; Shimamura, S.; Kamikawa, R.; Chikaraishi, Y.; Nunoura, T.
10.1101/2025.03.31.646503 — microbiology — Posted on 2025-04-01
5193 Persisters are primed for CRISPR-Cas adaptation
Mauritzen, J. J.; Wajn, A. S.; Hitz, I. F.; Hoeyland-Kroghsbo, N. M.
10.1101/2025.04.01.646530 — microbiology — Posted on 2025-04-01
5194 Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology
Ma, Q.-L.; Ebright, B.; Li, B.; Li, J.; Galvan, J.; Sanchez, A.; Renteln, M.; Dikeman, D.; Wang, S.; Kerman, B. E.; Seidler, P. M.; Gutierrez-Grebenkova, B.; Hjelm, B. E.; Hawes, D.; Hiniker, A. E.; Hurth, K. M.; Bennett, D. A.; Louie, S. G.; Chui, H. C.; Limon, A.; Arvanitakis, Z.; Yassine, H. N.
10.1101/2025.03.27.645605 — neuroscience — Posted on 2025-04-01
5195 Ethological profiling of pain and analgesia in a mouse model of complex regional pain syndrome.
Muwanga, G. P. B.; Pang, A.; Ewbank, S. N.; Siliezar-Doyle, J.; Nippert, A. R.; Airan, R. D.; Tawfik, V. L.
10.1101/2025.03.28.644648 — neuroscience — Posted on 2025-04-01
5197 Secretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling
Deshmukh, A.; Chang, K.; Cuala, J.; Campos, M. J. H.; Mahmood, S.; Verma, R.; Georgia, S.; Loconte, V.; White, K. L.
10.1101/2025.03.29.644646 — biophysics — Posted on 2025-04-01
5200 The impact of fungal developmental structures on mechanical properties of mycelial materials.
Gray, K. J.; Edwards, H.; Doan, A. G.; Huso, W.; Lee, J.; Pan, W.; Bolima, N.; Gautam, I.; Wang, T.; Srivastava, R.; Zupan, M.; Harris, S.; Marten, M. R.
10.1101/2025.04.01.644731 — bioengineering — Posted on 2025-04-01
5202 Elevated hydrostatic pressure acts via piezo-1 to destabilise VE-cadherin junctions: an endothelium-on-chip study
Bathrinarayanan, P. V.; Abadie, T.; Esteban, P. P.; Vigolo, D.; Simmons, M. J. H.; Grover, L. M.
10.1101/2025.03.27.645710 — bioengineering — Posted on 2025-04-01
5203 In vivo activation of the dia BGC allows consolidation of the biosynthetic pathways of diaporthin, dichlorodiaporthin, diaporthinic acid, and diaporthinol
Burger, I.; Leonhartsberger, S.; Peikert, K.; Fourtis, L.; Atanasova, P.; Kramer, L. T.; Fried, R.; Stanetty, C.; Rudroff, F.; Birner-Gruenberger, R.; Mach, R. L.; Mach-Aigner, A. R.; Schittmayer, M.; Zimmermann, C.
10.1101/2025.03.31.646288 — biochemistry — Posted on 2025-04-01
5204 Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening
Zhou, H.; Zhou, T.; Yu, W.; Liu, L.; Ko, Y.; Johnson, K. A.; Wilson, I. A.; Schultz, P. G.; Bollong, M. J.
10.1101/2025.03.31.646306 — biochemistry — Posted on 2025-04-01
5205 Cytological and preliminary genomic analysis of two Leptodactylus frog species (Anura, Leptodactylidae) with recently evolved large meiotic rings of multiple X and Y sex chromosomes
Vidal, J. A.; Charlesworth, D.; Ma, W.-J.; Zhou, Q.; Utsunomia, R.; Gomes, A. J.; da Silva, A. B.; Porto-Foresti, F.; Liehr, T.; Cioffi, M. d. B.
10.1101/2025.03.27.645801 — evolutionary biology — Posted on 2025-04-01
5207 Multi-scale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts
Molina-Riquelme, I.; Barrientos, G.; Breitsprecher, L.; Gomez, W.; Diaz-Castro, F.; Morris, S.; del Campo, A.; Garrido-Olivares, L.; Verdejo, H.; Psathaki, O. E.; Busch, K. B.; Eisner, V.
10.1101/2025.04.01.644555 — cell biology — Posted on 2025-04-01
5208 An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.
Ali, M.; Dura, R.; Guery, M.-A.; Colard-Itte, E.; Cheviet, T.; Robresco, L.; Berry, L.; Lionne, C.; Lavazec, C.; Claessens, A.; Peyrottes, S.; Wengelnik, K.; Wein, S.; Cerdan, R.
10.1101/2025.04.01.645218 — microbiology — Posted on 2025-04-01
5210 Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy
De Maeyer, R. P.; Sikora, J.; Bracken, O. V.; Shih, B. B.-J.; Lloyd, A. F.; Peckham, H. F.; Hollett, K.; Abdelhamid, K.; Cai, W.; James, M.; Pfeffer, P. E.; Vukmanovic-Stejic, M.; Akbar, A. N.; Chambers, E. S.
10.1101/2025.03.28.645904 — immunology — Posted on 2025-04-01
5211 Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy
Li, Y.; Sadri, Z.; Blandin, K. J.; Narvaiz, D. A.; Aryal, U. K.; Lugo, J. N.; Poolos, N. P.; Brewster, A. L.
10.1101/2025.03.27.645753 — neuroscience — Posted on 2025-04-01
5213 "Visualize, describe, compare" - nanoinformatics approaches for material-omics
Izquierdo-Lozano, C.; Tholen, M. M. E.; Girola, V.; Swietlikowska, A.; Merkx, M.; Grisoni, F.; Albertazzi, L.
10.1101/2025.03.27.645714 — bioinformatics — Posted on 2025-04-01
5217 Phylogenetics, evolution and biogeography of four Digitaria food crop lineages across West Africa, India, and Europe
Burton, G. P.; Ceci, P.; MacKinnon, L.; Masters, L.; Ryan, P.; Turnbull, C.; Ulian, T.; Vorontsova, M. S.
10.1101/2025.03.27.645812 — genetics — Posted on 2025-04-01
5221 Natural spider silk enhances mechanical performance of collagen scaffold under stretching conditions
Tso, I.-M.; Tsiareshyna, M.; Huang, S. Y. T.; Liao, C.-P.; Tang, M.-J.; Wong, T.-Y.
10.1101/2025.03.27.645864 — zoology — Posted on 2025-04-01
5222 Non-destructive monitoring of tissue-specific, irrigation responsive impedance signals in leaves using microneedles probes
Read, K. J. H.; Hudson, P. J.; Monclova, J.; Monteith, H.; Polsky, R.; Seitz, K.; Hanson, D. T.; Miller, P. R.
10.1101/2025.03.31.646420 — plant biology — Posted on 2025-04-01
5224 The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating
Gonzalez-Sanabria, N.; Contreras, G. F.; Rojas, M.; Duarte, Y.; Gonzalez-Nilo, F. D.; Perozo, E.; Latorre, R.
10.1101/2025.03.27.645783 — biophysics — Posted on 2025-04-01
5225 In-solution Characterization of Biomolecular Interaction Kinetics under Native Conditions
Willmer, P.; Stender, E. G.; Ray, K. S.; Hundahl, A. C.; Marie, R.; Jensen, H.
10.1101/2025.03.27.645748 — biophysics — Posted on 2025-04-01
5227 GeneWhisperer: Enhancing manual genome annotation with large language models
Li, X.; Whan, A. P.; McNeil, M.; Andrew, S. C.; Dai, X.; Fechner, M.; Paris, C.; Suchecki, R.
10.1101/2025.03.30.646211 — bioinformatics — Posted on 2025-04-01
5229 Functional profiling of KCNE1 variants informs population carrier frequency of Jervell and Lange-Nielsen syndrome type 2
Vanoye, C. G.; Desai, R. R.; John, J.; Hoffman, S.; Fink, N.; Zhang, Y.; Venkatesh, O.; Roe, J.; Adusumilli, S.; Jairam, N.; Sanders, C.; Gordon, A.; George, A. L.
10.1101/2025.03.28.646046 — genetics — Posted on 2025-04-01
5230 Surveillance of Japanese Encephalitis Virus in Piggery Effluent and Environmental Samples: A Complementary Tool for Outbreak Detection
Ahmed, W.; Gebrewold, M.; Williams, D. T.; Wang, J.; Smith, W.; Starick, L. G.; Fogarty, R. M.; Richards, K.; Simpson, S.
10.1101/2025.03.27.645166 — molecular biology — Posted on 2025-04-01
5231 Archaeological Bolivian maize genomes suggest Inca cultural expansion augmented maize diversity in South America
Chen, H.; Baetsen-Young, A.; Thompson, A.; Day, B.; Madzima, T.; Wasef, S.; Rivera Casanovas, C.; Lovis, W.; Wrobel, G.
10.1101/2025.03.31.646424 — plant biology — Posted on 2025-04-01
5232 Developing the Grapevine Hydric Stress Atlas: A Meta-Analysis Resource for Exploring transcriptome Responses to Drought
VALENZUELA, A. V.; Navarro-Paya, D.; Santiago, A.; Sonego, P.; Gainza-Cortes, F.; Malnoy, M.; Matus, J. T.
10.1101/2025.03.31.646369 — plant biology — Posted on 2025-04-01
5234 Simulated metabolic profiles reveal biases in pathway analysis methods
Cooke, J.; Wieder, C.; Poupin, N.; Frainay, C.; Ebbels, T.; Jourdan, F.
10.1101/2025.03.27.645696 — bioinformatics — Posted on 2025-04-01
5236 A differentiated and durable allogeneic strategy applicable to cell therapies
Jetley, U.; Balwani, I.; Sharma, P.; Miller, I.; Luther, A.; Dutta, I.; Saravanan, N.; Zhang, Q.; Zhang, B.; Kilic, O.; Liu, B.; Han, B. W.; Liu, D.; Schultes, B.; Prodeus, A.; Zhang, Y.
10.1101/2025.03.27.645807 — bioengineering — Posted on 2025-04-01
5239 BioToken and BioFM - Biologically-Informed Tokenization Enables Accurate and Efficient Genomic Foundation Models
Medvedev, A.; Viswanathan, K.; Kanithi, P.; Vishniakov, K.; Munjal, P.; Christophe, C.; Pimentel, M. A.; Rajan, R.; Khan, S.
10.1101/2025.03.27.645711 — genomics — Posted on 2025-04-01
5240 Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity
Meade, R. K.; Adefisayo, O. O.; Gontijo, M. T. P.; Harris, S. J.; Pyle, C. J.; Wilburn, K. M.; Ecker, A. M. V.; Hughes, E. J.; Garcia, P. D.; Ivie, J.; McHenry, M. L.; Benchek, P. H.; Mayanja-Kizza, H.; Neff, J. L.; Ko, D. C.; Stout, J. E.; Stein, C. M.; Hawn, T. R.; Tobin, D. M.; Smith, C. M.
10.1101/2025.04.01.644622 — genetics — Posted on 2025-04-01
5242 CELF2 suppresses endogenous RNA ligands that activate RIG-I-mediated interferon induction
Smith, J. R.; Kern, O. C.; Mishra, G.; Gokhale, N. S.; Etzyon, N.; Somfleth, K.; Schwerk, J.; Nakamichi, K.; Pugliano, C. M.; Lindbloom-Brown, Z.; Gale, M.; Savan, R.
10.1101/2025.03.27.645787 — immunology — Posted on 2025-04-01
5244 TARP γ-8 is a target of ethanol that regulates self-administration and relapse in mice
Faccidomo, S.; Hoffman, J. L.; Lee, J.; Whindleton, C. M.; Kim, M.; Taylor, S.; Kim, A.; Richter, C.; Seiters, H.; Bryant, J.; Chang, A.; Smith, E.; Agoglia, A. E.; Tomita, S.; Herman, M. A.; Hodge, C. W.
10.1101/2025.03.27.645788 — neuroscience — Posted on 2025-04-01
5246 Faster relaxation of nonphotochemical quenching (NPQ) in C4 than in C3 species
Cubas, L. A.; Nakamura, A.; Vath, R. L.; Rodrigues Gabriel Sales, C.; Bernardo, E. L.; Munekage, Y.; Kromdijk, J.
10.1101/2025.04.01.646649 — plant biology — Posted on 2025-04-01
5247 Xylan modifications in Populus that lead to increased growth
Urbancsok, J.; Donev, E. N.; Derba-Maceluch, M.; Sivan, P.; Barbut, F. R.; Mitra, M.; Yassin, Z.; Cermanova, K.; Simura, J.; Karady, M.; Scheepers, G.; Mellerowicz, E. J.
10.1101/2025.03.31.646328 — plant biology — Posted on 2025-04-01
5249 Genetic architecture of the S-locus supergene revealed in a tetraploid distylous species
Luo, Z.; Barrett, S. C. H.; Tu, T.; Zhao, Z.; Jia, S.; Gu, S.; Duan, T.; Zhang, Y.; Xu, B.; Gu, L.; Jiang, L.; Deng, X.; Shi, M.; Zhang, D.
10.1101/2025.04.01.646584 — plant biology — Posted on 2025-04-01
5251 A multi-modal cell-free RNA language model for liquid biopsy applications
Karimzadeh, M.; Sababi, A. M.; Momen-Roknabadi, A.; Chen, N.-C.; Cavazos, T. B.; Sekhon, S.; Wang, J.; Hanna, R.; Huang, A.; Nguyen, D.; Chen, S.; Lam, T.; Hartwig, A.; Fish, L.; Li, H.; Behsaz, B.; Hormozdiari, F.; Alipanahi, B.; Goodarzi, H.
10.1101/2025.03.26.645557 — bioinformatics — Posted on 2025-04-01
5253 Highly pathogenic avian influenza management in high-density poultry farming areas
Guinat, C.; Valuenzuela Agui, C.; Briand, F.-X.; Chakraborty, D.; Fourtune, L.; Lambert, S.; Jimenez Pellicer, A.; Rautureau, S.; Gerbier, G.; du Plessis, L.; Stadler, T.; Grasland, B.; Paul, M.; Vergne, T.
10.1101/2025.03.25.645233 — evolutionary biology — Posted on 2025-04-01
5255 Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons
Giannoni Guzman, M. A.; Zepeda, J. C.; Kamitakahara, A.; Magalong, V.; Levitt, P.; Grueter, B.; McMahon, D. G.
10.1101/2025.03.29.646123 — neuroscience — Posted on 2025-04-01
5256 Brain structural modules associated to functional high-order interactions in the human brain
Camino-Pontes, B.; Jimenez-Marin, A.; Tellaetxe-Elorriaga, I.; Fernandez-Iriondo, I.; Erramuzpe, A.; Diez, I.; Bonifazi, P.; Gatica, M.; Rosas, F. E.; Marinazzo, D.; Stramaglia, S.; Cortes, J.
10.1101/2025.03.21.644509 — neuroscience — Posted on 2025-04-01
5261 Leafy liverwort genomes shed light on the evolution of ericoid symbiosis
Castanedo, L.; Bianconi, M.; Pellen, T.; Vernie, T.; Lefort, C.; Libourel, C.; Le Ru, A.; Rodde, N.; Cauet, S.; Callot, C.; Forrest, L.; Nishiyama, T.; Wickell, D.; Li, F.-W.; Keller, J.; Delaux, P.-M.
10.1101/2025.04.01.646537 — plant biology — Posted on 2025-04-01
5262 Evolutionary Trade-off Between Stomatal Defense and Gas Exchange in Brassicaceae
Kang, W.; Nakano, M.; Fukumoto, K.; Hirata, R.; Zhai, P.; Du, Y.; Hong, K.; Ziegler, J.; Tsuda, Y.; Becker, D.; Nambara, E.; Nakano, R. T.; Miyashima, S.; Mine, A.; Han, X.; Tsuda, K.
10.1101/2025.03.31.646295 — plant biology — Posted on 2025-04-01
5263 CDK12 condensation in nuclear speckles confers sensitivity to cyclin K molecular glue degraders
Ye, K.; He, Q.; Cheng, Y.; Zhang, M.; Mu, H.; Cai, M.-C.; Zhou, S.; Xiang, H.; Hou, Y.; Li, Y.; Zang, Y.; Lv, J.; Cheng, L.; Xiang, L.; Zhao, D.; Zhang, Y.; Li, Y.; Yin, X.; Di, W.; Shen, P.; Zhuang, G.; Tan, L.
10.1101/2025.03.31.646293 — cancer biology — Posted on 2025-04-01
5264 FMO4 drives lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and hindering ferroptosis
Bracquemond, D.; Mahdizadeh, S. J.; Brunet, L.; Thomas, Q. D.; Bouclier, C.; Colomb, M.; Bourdel, S.; Fabbrizio, E.; Tourriere, H.; Papon, L.; Quantin, X.; Santos, A.; Ferrer, I.; Henry, S.; Grosgeorges, M.; Perna, V.; Lozano, M. D.; Solorzano, J. L.; Bossowski, J. P.; Papagiannakopoulos, T.; Tiseo, M.; Minari, R.; Turtoi, A.; Mange, A.; Montuenga, L. M.; Paz-Ares, L.; Faget, j.; Eriksson, L. A.; Mancini, M.; Maraver, A.
10.1101/2025.03.31.646284 — cancer biology — Posted on 2025-04-01
5267 DNA origami directed nanometer-scale integration of colloidal quantum emitters with silicon photonics
Luo, X.; Ranno, L.; Sverko, T.; Lee, J. Y.; Sbalbi, N.; Jones, A.; Chen, C.; Bawendi, M. G.; Hu, J.; Macfarlane, R. J.; Bathe, M.
10.1101/2025.01.23.634416 — bioengineering — Posted on 2025-04-01
5268 Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions
Keith, A.; Xu, T.; Chernova, T.; Keen, M.; Bogacz, M.; Nedeljkovic, M.; Flowers, M.; Brown, T.; Frank, F.; Ortlund, E. A.; Sundberg, E.
10.1101/2025.03.28.645945 — biochemistry — Posted on 2025-04-01
5269 NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Wu, Z.; Nguyen, P. T.; Sondhi, V.; Yao, R.-W.; Dai, T.; Chiang, J.-C.; Shang, Z.; Cai, F.; Zhang, J.; Moore, M. D.; Alshamleh, I.; Li, X.; Ogu, T.; Zacharias, L. G.; Winston, R.; Patricio, J. S.; Johnson, X.; Chen, W.-M.; Cong, Q.; Mathews, T. P.; Zhang, Y.; DeBerardinis, R. J.
10.1101/2025.03.29.646096 — biochemistry — Posted on 2025-04-01
5270 Smoothened inhibition of PKA at cilia transduces Hedgehog signals
Nguyen, T. D.; Konjikusic, M. J.; Castillo, L. D.; Reiter, J. F.
10.1101/2025.04.01.646243 — biochemistry — Posted on 2025-04-01
5272 Identification of genetic and non-genetic modifiers of genomic imprinting through whole genome screening in humans
Cecere, F.; Relator, R.; Levy, M.; Verma, A.; McConkey, H.; Hay Mele, B.; Pignata, L.; Giaccari, C.; D'Angelo, E.; Saha, S.; Saadat, A.; Sparago, A.; Angelini, C.; Cerrato, F.; Sadikovic, B.; Riccio, A.
10.1101/2025.03.27.645693 — genetics — Posted on 2025-04-01
5273 Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes
YI, J.; MOREL, J.; COSTALLAT, M.; LEJAL, N.; DELMAS, B.; MUCHARDT, C.; Batsche, E.
10.1101/2022.03.30.486363 — molecular biology — Posted on 2025-04-01
5275 Vaccine-induced and hybrid immunity against SARS-CoV-2 variants of concern in two cohorts in Queensland, Australia (2021-2022).
Parry, R. H.; Shang, Y. H.; Sng, J. D. J.; McMillan, C. L. D.; Modhiran, N.; Amarilla, A. A.; Isaacs, A.; Liang, B.; Muller, D. A.; Rawle, D. J.; Suhrbier, A.; Anderson, S.; Kelly, S.; Watterson, D.; Burr, L.; Khromykh, A.
10.1101/2024.11.11.623100 — microbiology — Posted on 2025-04-01
5277 Early-life stress alters chromatin modifications in VTA to prime stress sensitivity
Geiger, L. T.; Balouek, J.-A. R.; Barrett, M. R.; Thompson, J. M.; Fang, L. Z.; Farrelly, L. A.; Chen, A. S.; Tang, M.; Bennett, S. N.; Garcia, B. A.; Maze, I.; Creed, M. C.; Pena, C. J.
10.1101/2024.03.14.584631 — neuroscience — Posted on 2025-04-01
5278 Unraveling the mesoscale functional connectivity of the human primary visual cortex using high-resolution functional MRI.
Schmidt, M. E.; Aganj, I.; Stockmann, J.; Bilgic, B.; Chang, Y.; Hoge, W. S.; Kirilina, E.; Weiskopf, N.; Nasr, S.
10.1101/2025.03.27.645795 — neuroscience — Posted on 2025-04-01
5279 Adapt-A-Maze: An Open Source Adaptable and Automated Rodent Behavior Maze System
Porter, B. S.; Olson, J. M.; Leppla, C. A.; Duvelle, E.; Bladon, J. H.; van der Meer, M. A.; Jadhav, S. P.
10.1101/2021.06.05.447225 — neuroscience — Posted on 2025-04-01
5280 Population responses in V1 encodes stimulus visibility in backward masking
Dennis, I. T.; Edelman-Klapper, H.; Gadi-Raveh, G.; Bar-Shira, O.; Margalit, S. N.; Slovin, H.
10.1101/2025.03.30.642841 — neuroscience — Posted on 2025-04-01
5284 A Versatile and Open Source One- and Two-Photon Light-Sheet Microscope Design
Hubert, A.; Panier, T.; Migault, G.; Trentesaux, H.; Beaudou, B.; Debregeas, G.; Bormuth, V.
10.1101/2023.07.10.548107 — neuroscience — Posted on 2025-04-01
5285 AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling
Jang, H.; Liu, Z.; Li, Y.; Zhong, X.; Qu, Y.; Li, S.; Dai, L.; Zhang, Y.; Wang, M.; Zhang, W.; Liu, W.; He, X.; Dong, W.; Madhusudhan, T.; Li, Z.; Wang, H.; Zeng, H.
10.1101/2025.03.26.645618 — pharmacology and toxicology — Posted on 2025-04-01
5286 Advancing RNAi-Based Strategies Against Downy Mildews: Insights Into dsRNA Uptake and Gene Silencing
Gol, D.; Okechukwu, E. C.; Unal, G.; Webb, A.; Wood, T.; Hong, Y.; Sherif, S.; Wacker, T.; Studholme, D. J.; McDowell, J.; Tor, M.
10.1101/2025.03.31.646348 — plant biology — Posted on 2025-04-01
5289 mcDETECT: Decoding 3D Spatial Synaptic Transcriptomes with Subcellular-Resolution Spatial Transcriptomics
Yuan, C.; Patel, K.; Shi, H.; Wang, H.-L.; Wang, F.; Li, R.; Li, Y.; Corces, V.; Shi, H.; Das, S.; Yu, J.; Jin, P.; Yao, B.; Hu, J.
10.1101/2025.03.27.645744 — bioinformatics — Posted on 2025-04-01
5295 Sirtuin 2 controls global protein synthesis by regulating Rheb-GTPase
Shrama, A.; Zi, Y.; Pandit, A. S.; Jha, K.; Sinha, V. K.; Ravi, V.; Ghosh, S.; Nagesh, D.; Shivanaiah, B.; Khan, D.; Prabhashankar, A. B.; Sumi, T. S.; Raghu, S.; Srivastava, A.; Singh, M.; Lin, H.; Sundaresan, N. R.
10.1101/2025.03.31.646364 — cell biology — Posted on 2025-04-01
5296 Differential cell survival outcomes in response to diverseamino acid stress
Murray, P. J.; Russier, M.; Fiore, A.; Gross, A.; Tanzer, M.; Yeroslaviz, A.; Mann, M.
10.1101/2025.04.01.646536 — cell biology — Posted on 2025-04-01
5297 Impact of Serum Circulating Factors and PDE5 Inhibitor Therapy on Cardiomyocyte Metabolism in Single Ventricle Heart Disease
Garcia, A. M.; Pietra, A. E.; Turner, M. E.; Pires Da Silva, J.; Baybayon-Grandgeorge, A. N.; Sparagna, G. C.; Jeffrey, D. A.; Stauffer, B. L.; Sucharov, C. C.; Miyamoto, S. D.
10.1101/2025.03.31.646497 — cell biology — Posted on 2025-04-01
5300 Single Nucleus Multiome Analysis Reveals Early Inflammatory Response to High-Fat Diet in Mouse Pancreatic Islets
Ernst, I. V. S.; Lehtonen, L.; Nilsson, S. M.; Nielsen, F. L.; Marcher, A.-B.; Mandrup, S.; Madsen, J. G. S.
10.1101/2025.04.01.646568 — cell biology — Posted on 2025-04-01
5302 Cytokine-driven cellular polarization in preeclampsia revealed through the "Dictionary of immune responses"
Wan, S.; Zhou, T.; Ma, Y.; Chen, Y.; Zhou, C. C.; Peng, J.; Lin, L.; Luo, W.; Gu, W.; Liu, Z.; Hua, X.
10.1101/2025.03.26.645616 — bioinformatics — Posted on 2025-04-01
5303 Mapping Histoplasma in Bats and Cave Ecosystems: Evidence from Midwestern Brazil
Bernardes, J. P. R. A.; Tenorio, B. G.; Lucas, J. M.; Paternina, C. E. M.; Silva, R. K. M.; Erazo, F. A. H.; Silva-Pereira, I.; Alves, L. G. d. B.; Arenas, P. H. R.; Bueno-Rocha, I. D.; Magalhaes, E. D.; de Sousa, H. R.; Paes, H.; Zancope-Oliveira, R. M.; Matute, D. R.; Felipe, M. S. S.; Aguiar, L. M. d. S.; Charneau, S. O.; Nicola, A. M.; Teixeira, M. d. M.
10.1101/2025.03.31.641930 — microbiology — Posted on 2025-04-01
5305 Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22
Maru, S. Y.; Wetzel, M.; Mitchell, J. T.; Gross, N. E.; Andaloori, L.; Howe, K.; Kartalia, E.; Mo, G.; Leatherman, J.; Ho, W. J.; Fertig, E. J.; Kagohara, L. T.; Pearce, E. J.; Jaffee, E. M.
10.1101/2025.03.27.645833 — cancer biology — Posted on 2025-04-01
5307 Rapid optimization of protein function in mammalian cells via microbe-independent deep assembly and screening
Wu, Y.; Wang, P.; Liu, L. X.; Gao, C.; Qin, Q.; Hageman, M.; Kirkland, T. A.; Su, Y.; Lin, M. Z.
10.1101/2025.03.30.646252 — bioengineering — Posted on 2025-04-01
5308 Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes
Hazell Pickering, S.; Galigniana, N. M.; Abdelhalim, M.; Sorensen, A. L.; Zucknick, M.; Collas, P.; BRIAND, N.
10.1101/2025.03.28.645896 — genomics — Posted on 2025-04-01
5309 Amino Acid Substitutions in the Na+/K+-ATPase May Contribute to Salinity Tolerance in Insects
Achi, P.; Iglesias, V.; Christensen, P.; Adrianza, R.; Bavier, L.; Pena, R.; McCarthy, C.; Groen, S. C.; Dillman, A. R.
10.1101/2025.03.27.645771 — genetics — Posted on 2025-04-01
5310 New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster
Rai, M.; Okah, P.; Shefali, S. A.; Fitt, A. J.; Shen, M. Z.; Molomjamts, M.; Pepin, R.; Nemkov, T.; D'Alessandro, A.; Tennessen, J.
10.1101/2025.03.27.645621 — genetics — Posted on 2025-04-01
5312 Vascular Biomechanics and Brain Biochemistry in Aged and Alzheimer's Disease Mouse Models
Jones, A.; Jarrahi, A.; Karpowich, K.; Brown, L.; Schulz, K. M.; Prosser, R. A.; Crouch, C.
10.1101/2025.03.27.645832 — neuroscience — Posted on 2025-04-01
5313 Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy
Sorelli, M.; Di Meo, D.; Bradley, S.; Cheli, F.; Ramazzotti, J.; Perego, L.; Destrieux, C.; Hof, P. R.; Pavone, F. S.; Mazzamuto, G.; Costantini, I.
10.1101/2025.03.31.645981 — neuroscience — Posted on 2025-04-01
5314 In situ structure of a gap junction - stomatin complex
Rosenkranz, N.; Wieland, K.; Birtasu, A. N.; Manger, S.; Bhattacharya, A.; Frangakis, A. S.; Gottschalk, A.
10.1101/2025.03.27.645584 — neuroscience — Posted on 2025-04-01
5320 Baclofen, a GABAB receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas
Grigoras, I. F.; Geist, E.; Johnstone, A.; Clarke, W. T.; Emir, U.; Nettekoven, C.; Levenstein, J. M.; Capitao, L.; Stagg, C. J.
10.1101/2025.03.27.645701 — neuroscience — Posted on 2025-04-01
5322 The Reward Positivity Does Not Encode Current Reward Value
Shaffer, L. S.; Crowder, H. D.; Kakalec, P. A.; Duong, L. T.; McDonald, C. G.; Thompson, J. C.
10.1101/2025.03.27.645774 — neuroscience — Posted on 2025-04-01
5323 Trial-Level Representational Similarity Analysis
Huang, S.; Howard, C. M.; Bogdan, P. C.; Morales-Torres, R.; Slayton, M.; Cabeza, R.; Davis, S. W.
10.1101/2025.03.27.645646 — neuroscience — Posted on 2025-04-01
5324 Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets
Rancati, S.; Pereira, R. C.; Schlich, M.; Sgroi, S.; Beatini, S.; La Rosa, L.; Giantomasi, L.; Pelizzoli, R.; Braccia, C.; Spattini, C.; Tuntevski, K.; Lo Van, A.; Espinal, M. P.; Palange, A.; Bajetto, A.; Daga, A.; Armirotti, A.; Florio, T.; Decuzzi, P.; Tonelli, D. D. P.
10.1101/2025.03.27.645741 — cancer biology — Posted on 2025-04-01
5325 Loss of Kmt2c/d promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy
Wang, N.; Li, D.; Zhang, T.; Pachai, M. R.; Cho, W. H.; Khudoynazarova, M. N.; Schoeps, D. M.; Bao, Y.; Liu, M.; Tang, L.; Janjigian, Y.; Chi, P.; Chen, Y.
10.1101/2025.03.27.645747 — cancer biology — Posted on 2025-04-01
5327 The SRG RAT supports human cell xenotransplantation through enhanced tumor microenvironment interactions
O'Connor, C. M.; Zawacki, K. P.; Durrant, J. R.; Barrie, K.; Walton, R. G.; King, D.; Hodges-Onishi, G.; Noto, F. K.; Hinderman, M.; Begemann, D.; Branyan, T.; Panwell, K.; DiFeo, A.; Schlosser, M. J.; Narla, G.
10.1101/2025.03.27.645250 — cancer biology — Posted on 2025-04-01
5328 Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma
van Oost, S.; Meijer, D. M.; Erdem, Z. B.; IJsselsteijn, M. E.; Roelands, J.; Lam, S. W.; Boejharat, M. S.; van den Akker, B. E. W. M.; van der Breggen, R.; Briaire-de Bruijn, I. H.; Hawinkels, L. J. A. C.; Kruiswijk, A. A.; van der Ploeg, M.; Wijers-Koster, P. M.; Haas, R. L.; van de Sande, M. A. J.; de Miranda, N. F. C. C.; Bovee, J. V. M. G.
10.1101/2025.03.27.645727 — cancer biology — Posted on 2025-04-01
5329 Single-cell profiling of CAR-T CD19 cell phenotypes and immune system dynamics in pediatric BCP-ALL
Oszer, A.; Pawlik, B.; Cwilichowska-Puslecka, N.; Marschollek, P.; Richert-Przygonska, M.; Mielcarek-Siedziuk, M.; Crawford, J. C.; Mazurek, M.; Koladiya, A.; Kalwak, K.; Styczynski, J.; Janczar, S.; Poreba, M.; Velasquez, P. M.; Davis, K. L.; Mlynarski, W.
10.1101/2025.03.27.645594 — cancer biology — Posted on 2025-04-01
5334 MouseGPT: A Large-scale Vision-Language Model for Mouse Behavior Analysis
Xu, T.; Zhou, T.; Wang, Y.; Yang, P.; Tang, S.; Shao, K.; Tang, Z.; Liu, Y.; Chen, X.; Wang, H.; Wang, X.; Luo, H.; Wang, J.; Hu, J.; Yu, J.
10.1101/2025.03.27.645630 — animal behavior and cognition — Posted on 2025-04-01
5337 Exonic enhancers are a widespread class of dual-function regulatory elements
Mouren, J.-C.; Torres, M.; van Ouwerkerk, A.; Manosalva, I.; Gallardo, F.; Spicuglia, S.; Ballester, B.
10.1101/2025.03.27.645641 — genomics — Posted on 2025-04-01
5342 Weak effects of local prey density and spatial overlap on predation intensity in a temperate marine ecosystem
Lindmark, M.; Griffiths, C. A.; Bartolino, V.; Thunell, V.; Maioli, F.; Anderson, S. C.; Belgrano, A.; Casini, M.; Nadolna-Ałtyn, K.; Pawlak, J.; Pachur, M.; Rakowski, M.; Wikström, K.; Thompson, M. S. A.; Gogina, M.; Ustups, D.; Jacobsen, N. S.
10.1101/2025.03.27.645454 — ecology — Posted on 2025-04-01
5343 Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development
Wiszniak, S.; Alankarage, D.; Lohraseb, I.; Marchant, C.; Secker, G.; Parker, W.; Toubia, J.; White, M.; Piltz, S.; Tondl, M.; Giannoulatou, E.; Winlaw, D.; Blue, G. M.; Congenital Heart Disease Synergy Group, ; Tam, P. P. L.; Thomas, P.; Harvey, N.; Dunwoodie, S. L.; Schwarz, Q.
10.1101/2025.03.27.645622 — developmental biology — Posted on 2025-04-01
5344 Actin-related protein M1 (ARPM1) required for acrosome biogenesis and sperm function in mice
Kovacevic, A.; Ordziniak, E.; Umer, N.; Arevalo, L.; Hinterlang, L. D.; Ziaeipour, S.; Suvilla, S.; Merges, G. E.; Schorle, H.
10.1101/2025.03.27.645694 — developmental biology — Posted on 2025-04-01
5346 The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors
Oosenbrug, T.; Gravekamp, D.; Pinto-Fernandez, A.; Crotta, S.; Finsterbusch, K.; van der Kooij, S. B.; ter Haar, L. R.; Asschert, Y.; Kleian, G. F. E.; Kessler, B. M.; Wack, A.; van der Veen, A. G.
10.1101/2025.03.27.645708 — immunology — Posted on 2025-04-01
5347 SB 11285, a Novel Canonical Purine-Pyrimidine Cyclic Dinucleotide, is a Systemically Bioavailable STING Agonist for Cancer Immunotherapy
Challa, R.; Zhou, S.; Sheri, A.; Meher, G.; Padmanabhan, S.; Khedkar, S.; Nair, V.; Gimi, R.; Cleary, D.; Iyer, R. P.
10.1101/2025.03.27.645620 — immunology — Posted on 2025-04-01
5351 Genetic surveillance of Plasmodium-Anopheles compatibility markers during Anopheles stephensi associated malaria outbreak
Waymire, E.; Getachew, D.; Gunarathna, I.; Spear, J.; Lloyd, G.; Follis, M.; Kaye, A. A.; Ali, S.; Yared, S.; Carter, T. E.
10.1101/2025.03.26.645571 — evolutionary biology — Posted on 2025-04-01
5352 A Bayesian approach to include Indigenous Knowledge in habitat selection functions
Gryba, R.; Von Duyke, A. L.; Huntington, H. P.; Adams, B.; Frantz, B.; Gatten, J.; Harcharek, Q.; Sarren, R.; Henry, G. H.; Auger-Methe, M.
10.1101/2025.03.26.645387 — ecology — Posted on 2025-04-01
5353 A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilance.
Guillaumin, A.; Dhellemmes, T.; Perrot, E.; Boi, L.; De Castro Medeiros, D.; Glangetas, C.; Dumas, S.; Dovero, S.; Biendon, N.; Ladeveze, E.; Landry, M.; Bezard, E.; Baufreton, J.; Fisone, G.; Georges, F.
10.1101/2025.03.31.646345 — neuroscience — Posted on 2025-04-01
5357 A Context-Free Model of Savings in Motor Learning
Shahbazi, M.; Codol, O.; Michaels, J. A.; Gribble, P. L.
10.1101/2025.03.26.645562 — neuroscience — Posted on 2025-04-01
5358 Suite3D: Volumetric cell detection for two-photon microscopy
Haydaroglu, A.; Dodgson, S.; Krumin, M.; Landau, A.; Baruchin, L. J.; Chang, T.; Guo, J.; Meyer, D.; Reddy, C. B.; Zhong, J.; Ji, N.; Schröder, S.; Harris, K. D.; Vaziri, A.; Carandini, M.
10.1101/2025.03.26.645628 — neuroscience — Posted on 2025-04-01
5359 Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain
Mwirigi, J. M.; Sankaranarayanan, I.; Tavares-Ferreira, D.; Gabriel, K. A.; Palomino, S.; Li, Y.; Uhelski, M. L.; Shiers, S.; Franco-Enzastiga, U.; Wangzhou, A.; Lesnak, J. B.; Bandaru, S.; Shrivastava, A.; Inturi, N.; Albrecht, P. J.; Dockum, M.; Cervantes, A. M.; Horton, P.; Funk, G.; North, R. Y.; Tatsui, C. E.; Corrales, G.; Yousuf, M. S.; Curatolo`, M.; Gereau, R. W.; Patwardhan, A.; Dussor, G.; Dougherty, P. M.; Rice, F. L.; Price, T. J.
10.1101/2025.03.26.645611 — neuroscience — Posted on 2025-04-01
5361 PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Secreted Proteins by Single Cells
Lussier, F.; Moon, B.-U.; Janta-Polczynski, M.; Morocz, Y.; Svahn, F.; Shen, M. L.; Lukic, L.; Malic, L.; Veres, T.; Ng, A.; Juncker, D.
10.1101/2025.03.26.645608 — bioengineering — Posted on 2025-04-01
5362 FOS binding sites are a hub for the evolution of activity-dependent gene regulatory programs in human neurons
Carter, A. C.; Koreman, G. T.; Petrocelli, J. E.; Robb, J. E.; Bushinsky, E. M.; Trowbridge, S. K.; Kingsley, D. M.; Walsh, C. A.; Song, J. H. T.; Greenberg, M. E.
10.1101/2025.03.31.646366 — evolutionary biology — Posted on 2025-04-01
5364 Impact of education and music training on the development of early abstraction abilities
Morfoisse, T.; Becuwe, S.; Palu, M.; Potier-Watkins, C.; Dehaene-Lambertz, G.; Dehaene, S.
10.1101/2025.03.28.645996 — neuroscience — Posted on 2025-04-01
5366 An unsuspected physiological role for mGluRIII glutamate receptors in hippocampal area CA1
Petroccione, M.; Melone, M.; Rathwell, T.; Dwivedi, N.; Grienberger, C.; Conti, F.; Scimemi, A.
10.1101/2025.03.31.646479 — neuroscience — Posted on 2025-04-01
5367 Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice
Dexter, T. D.; Palmer, D.; Schormans, A. L.; Hamidullah, S.; Machado, M. M. F.; Allman, B. L.; Bussey, T. J.; Saksida, L. M.
10.1101/2025.03.31.645999 — neuroscience — Posted on 2025-04-01