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Archive, 2021-05

2 Testing covariance models for MEG source reconstruction of hippocampal activity
ONeill, G. C.; Barry, D. N.; Tierney, T. M.; Mellor, S.; Maguire, E. A.; Barnes, G. R.
10.1101/2021.04.29.441929 — neuroscience — Posted on 2021-05-02
3 Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model
Hammer, M.; Huisman, M.; Rigano, A.; Boehm, U.; Chambers, J. J.; Gaudreault, N.; North, A. J.; Pimentel, J. A.; Sudar, D.; Bajcsy, P.; Brown, C. M.; Corbett, A. D.; Faklaris, O.; Lacoste, J.; Laude, A.; Nelson, G.; Nitschke, R.; Farzam, F.; Smith, C.; Grunwald, D.; Strambio-De-Castillia, C.
10.1101/2021.04.25.441198 — bioinformatics — Posted on 2021-05-31
5 Micro-Meta App: an interactive software tool to facilitate the collection of microscopy metadata based on community-driven specifications
Rigano, A.; Ehmsen, S.; Ozturk, S. U.; Ryan, J.; Balashov, A.; Hammer, M.; Kirli, K.; Bellve, K.; Boehm, U.; Brown, C. M.; Chambers, J. J.; Coleman, R. A.; Cosolo, A.; Faklaris, O.; Fogarty, K.; Guilbert, T.; Hamacher, A. B.; Itano, M. S.; Keeley, D. P.; Kunis, S.; Lacoste, J.; Laude, A.; Ma, W.; Marcello, M.; Montero-Llopis, P.; Nelson, G.; Nitschke, R.; Pimentel, J. A.; Weidtkamp-Peters, S.; Park, P. J.; Alver, B.; Grunwald, D.; Strambio-De-Castillia, C.
10.1101/2021.05.31.446382 — bioinformatics — Posted on 2021-05-31
7 The post-translational modification landscape of commercial beers
Kerr, E. D.; Caboche, C. H.; Pegg, C. L.; Phung, T. K.; Gonzalez Viejo, C.; Fuentes, S.; Howes, M. T.; Howell, K.; Schulz, B. L.
10.1101/2021.01.27.427706 — biochemistry — Posted on 2021-05-31
10 Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants
Liu, J.; Bodnar, B. H.; Wang, X.; Wang, P.; Meng, F.; Khan, A. I.; Saribas, A. S.; Padhiar, N. H.; McCluskey, E.; Shah, S.; Luo, J. J.; Hu, W.; Ho, W.-Z.
10.1101/2021.05.31.445871 — microbiology — Posted on 2021-05-31
11 Species-specific molecular barriers to SARS-CoV-2 replication in bat cells
Aicher, S.-M.; Streicher, F.; Chazal, M.; Planas, D.; Luo, D.; Buchrieser, J.; Nemcova, M.; Seidlova, V.; Zukal, J.; Serra-Cobo, J.; Pontier, D.; Schwartz, O.; Pikula, J.; Dacheux, L.; Jouvenet, N.
10.1101/2021.05.31.446374 — microbiology — Posted on 2021-05-31
12 Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2
Zech, F.; Schniertshauer, D.; Jung, C.; Herrmann, A.; Xie, Q.; Nchioua, R.; Prelli Bozzo, C.; Volcic, M.; Koepke, L.; Krueger, J.; Heller, S.; Kleger, A.; Jacob, T.; Conzelmann, K.-K.; Ensser, A.; Sparrer, K. M. J.; Kirchhoff, F.
10.1101/2021.05.31.446386 — microbiology — Posted on 2021-05-31
13 Accelerated Antibody Discovery Targeting the SARS-CoV-2 Spike Protein for COVID-19 Therapeutic Potential
Mullen, T. E.; Abdullah, R.; Boucher, J.; Brousseau, A. S.; Dasuri, N. K.; Ditto, N. T.; Doucette, A. M.; Emery, C.; Gabriel, J.; Greamo, B.; Patil, K. S.; Rothenberger, K.; Stolte, J.; Souders, C. A.
10.1101/2021.05.31.446421 — immunology — Posted on 2021-05-31
15 Single-Cell Profiling Resolved Transcriptional Alterations and Lineage Dynamics of Subventricular Zone after Mild Traumatic Brain Injury
Chen, X.; Cao, S.; Wang, Y.; Li, M.; Guo, Y.; Ye, Y.; Wang, Z.; Dai, H.; Yang, W.; Sun, Y.; Ou, X.; He, M.; Xie, X.; Liang, W.
10.1101/2021.05.31.446381 — neuroscience — Posted on 2021-05-31
18 A low repeated dose of Δ9-tetrahydrocannabinol affects memory performance through serotonergic signalling in mice
Galera-Lopez, L.; Salgado-Mendialdua, V.; Moreno, E.; Bergada-Martinez, A.; Hoffman, A.; Manzanares-Sierra, I.; Busquets-Garcia, A.; Casado, V.; Lupica, C.; Maldonado, R.; Ozaita, A.
10.1101/2021.05.31.446448 — neuroscience — Posted on 2021-05-31
20 3D atlas of the pituitary gland of the model fish medaka
Royan, M. R.; Siddique, K.; Csucs, G.; Puchades, M. A.; Nourizadeh-Lillabadi, R.; Bjaalie, J. G.; Henkel, C.; Weltzien, F.-A.; FONTAINE, R.
10.1101/2021.05.31.446412 — neuroscience — Posted on 2021-05-31
22 Tracking the Ancestry of Known and 'Ghost' Homeologous Subgenomes in Model Grass Brachypodium Polyploids
Sancho, R.; Inda, L. A.; Diaz-Perez, A. J.; Des Marais, D. L.; Gordon, S.; Vogel, J.; Lusinska, J.; Hasterok, R.; Contreras-Moreira, B.; Catalan, P.
10.1101/2021.05.31.446465 — plant biology — Posted on 2021-05-31
24 SLP2/prohibitins aggregates and instability of the PHB complex are key elements in CHCHD10S59L-related disease
GENIN, E. C.; Bannwarth, S.; Ropert, B.; Mauri-Crouzet, A.; Lespinasse, F.; Auge, G.; Fragaki, K.; Cochaud, C.; Lacas-Gervais, S.; Paquis-Flucklinger, V.
10.1101/2021.05.31.446377 — pathology — Posted on 2021-05-31
25 A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia
Reisman, B. J.; Guo, H.; Ramsey, H. E.; Wright, M. T.; Reinfeld, B. I.; Ferrell, P. B.; Sulikowski, G. A.; Rathmell, W. K.; Savona, M. R.; Plate, L.; Rubinstein, J. L.; Bachmann, B. O.
10.1101/2021.05.31.445492 — biochemistry — Posted on 2021-05-31
26 Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model
D'Alessandro, A.; Howie, H. L.; Hay, A. M.; Dziewulska, K. H.; Brown, B.; Wither, M. J.; Karafin, M.; Stone, E. F.; Spitalnik, S. L.; Hod, E. A.; Francis, R. O.; Fu, X.; Thomas, T.; Zimring, J. C.
10.1101/2021.05.31.446353 — biochemistry — Posted on 2021-05-31
28 Molecular foundations of Precambrian uniformitarianism
Kedzior, M.; Garcia, A. K.; Li, M.; Taton, A.; Adam, Z. R.; Young, J. N.; Kacar, B.
10.1101/2021.05.31.446354 — evolutionary biology — Posted on 2021-05-31
31 Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites
Warren, W. C.; Akopyants, N.; Dobson, D. E.; Hertz-Fowler, C.; Lye, L.-F.; Myler, P. J.; Ramasamy, G.; Shanmugasundram, A.; Silva-Franco, F.; Steinbiss, S.; Tomlinson, C.; Wilson, R. K.; Beverley, S. M.
10.1101/2021.05.29.446295 — microbiology — Posted on 2021-05-31
32 U-RISC: An Ultra-high Resolution EM Dataset Challenging Existing Deep Learning Algorithms
Shi, R.; Wang, W.; Li, Z.; He, L.; Sheng, K.; Ma, L.; Du, K.; Jiang, T.; Huang, T.
10.1101/2021.05.30.446334 — neuroscience — Posted on 2021-05-31
33 Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
Haeusl, A. S.; Brix, L. M.; Bajaj, T.; Poehlmann, M. L.; Hafner, K.; De Angelis, M.; Nagler, J.; Balsevich, G.; Schramm, K.-W.; Giavalisco, P.; Chen, A.; Schmidt, M. V.; Gassen, N. C.
10.1101/2021.05.31.445775 — neuroscience — Posted on 2021-05-31
37 Center-surround interactions underlie bipolar cell motion sensing in the mouse retina
Strauss, S.; Korympidou, M. M.; Ran, Y.; Franke, K.; Schubert, T.; Baden, T.; Berens, P.; Euler, T.; Vlasits, A. L.
10.1101/2021.05.31.446404 — neuroscience — Posted on 2021-05-31
39 Fear in the mind's eye: Mental imagery can generate and regulate acquired differential fear conditioned reactivity
Greening, S. G.; Lee, T.-H.; Burleigh, L.; Gregoire, L.; Robinson, T.; Jiang, X.; Mather, M.; Kaplan, J.
10.1101/2021.02.04.429795 — neuroscience — Posted on 2021-05-31
44 A molecular toolbox for ADP-ribosyl binding proteins
Sowa, S. T.; Galera-Prat, A.; Maksimainen, M. M.; Alanen, H. I.; Wazir, S.; Lehtio, L.
10.1101/2021.05.31.445082 — biochemistry — Posted on 2021-05-31
47 Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons
Anderson, J.; Lea, A. J.; Voyles, T.; Akinyi, M.; Nyakundi, R.; Ochola, L.; Omondi, M.; Nyundo, F.; Zhang, Y.; Campos, F. A.; Alberts, S. C.; Archie, E. A.; Tung, J.
10.1101/2021.05.31.446340 — genomics — Posted on 2021-05-31
48 The genetic impact of an Ebola outbreak on a wild gorilla population
Fontsere, C.; Frandsen, P.; Hernandez-Rodriguez, J.; Niemann, J.; Scharff-Olsen, C. H.; Vallet, D.; Le Gouar, P.; Menard, N.; Navarro, A.; Siegismund, H. R.; Hvilsom, C.; Gilbert, M. T. P.; Kuhlwilm, M.; Hughes, D. A.; Marques-Bonet, T.
10.1101/2021.05.31.446409 — genomics — Posted on 2021-05-31
49 Extensive aquatic subsidies lead to territorial breakdown and high density of an apex predator
Eriksson, C. E.; Kantek, D. L. Z.; Miyazaki, S. S.; Morato, R. G.; dos Santos-Filho, M.; Ruprecht, J. S.; Peres, C. A.; Levi, T.
10.1101/2021.03.29.437596 — ecology — Posted on 2021-05-31
50 Integrating ecological monitoring and local ecological knowledge to evaluate conservation outcomes
Early-Capistran, M.-M.; Solana-Arellano, E.; Abreu-Grobois, F. A.; Garibay-Melo, G.; Seminoff, J. A.; Saenz-Arroyo, A.; Narchi, N. E.
10.1101/2021.05.31.446466 — ecology — Posted on 2021-05-31
52 Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes
Soto, I. C.; Couvillion, M.; McShane, E.; Hansen, K. G.; Moran, J. C.; Barrientos, A.; Churchman, L. S.
10.1101/2021.05.31.446345 — cell biology — Posted on 2021-05-31
53 Role of the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway in Human β CellProliferation
Iorio, C.; Rourke, J. L.; Wells, L.; Sakamaki, J.-I.; Moon, E.; Hu, Q.; Kin, T.; Screaton, R.
10.1101/2021.05.31.446443 — cell biology — Posted on 2021-05-31
55 GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors
Moroy, T.; Helness, A.; Fraszczak, J.; Joly-Beauparlant, C.; Bagci, H.; Trahan, C.; Arman, K.; Shooshtarizadeh, P.; Ayoub, M.; Chen, R.; Cote, J.-F.; Oeffinger, M.; Droit, A.
10.1101/2021.05.31.446398 — molecular biology — Posted on 2021-05-31
56 Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP
Carbone, C. E.; Loveland, A. B.; Gamper, H.; Hou, Y.-M.; Demo, G.; Korostelev, A. A.
10.1101/2021.05.31.446434 — molecular biology — Posted on 2021-05-31
57 Single seed microbiota: assembly and transmission from parent plant to seedling
Chesneau, G.; Laroche, B.; Preveaux, A.; Marais, C.; Briand, M.; Marolleau, B.; Simonin, M.; Barret, M.
10.1101/2021.05.31.446402 — microbiology — Posted on 2021-05-31
58 The giant Staphylococcus epidermidis surface protein Embp binds selectively to fibrillated fibronectin through a Velcro-like mechanism
Khan, N.; Aslan, H.; Buttner, H.; Rohde, H.; Golbek, T. W.; Roeters, S. J.; Woutersen, S.; Weidner, T.; Meyer, R. L.
10.1101/2021.05.31.446437 — microbiology — Posted on 2021-05-31
59 Viruses roam the wheat phyllosphere
Forero-Junco, L. M.; Alanin, K. W. S.; Djurhuus, A. M.; Kot, W.; Gobbi, A.; Hansen, L. H.
10.1101/2021.05.31.446456 — microbiology — Posted on 2021-05-31
60 Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice
Bohrer, A. C.; Castro, E.; Hu, Z.; Queiroz, A. T. L.; Tocheny, C. E.; Assmann, M.; Sakai, S.; Nelson, C.; Baker, P. J.; Ma, H.; Wang, L.; Zilu, W.; du Bruyn, E.; Riou, C.; Kauffman, K. D.; Tuberculosis Imaging Program, ; Moore, I. N.; Del Nonno, F.; Petrone, L.; Goletti, D.; Martineau, A. R. R.; Lowe, D. M.; Cronan, M. R.; Wilkinson, R. J.; Barry, C. E.; Via, L. E.; Barber, D. L.; Klion, A. D.; Andrade, B. B.; Song, Y.; Wong, K.-W.; Mayer-Barber, K. D.
10.1101/2021.05.29.446277 — immunology — Posted on 2021-05-31
61 Pre-therapeutic Microglia Activation and Sex Determine Therapy Effects of Chronic Immunomodulation
Biechele, G.; Blume, T.; Deussing, M.; Zott, B.; Shi, Y.; Xiang, X.; Franzmeier, N.; Kleinberger, G.; Peters, F.; Ochs, K.; Focke, C.; Sacher, C.; Wind, K.; Schmidt, C.; Lindner, S.; Gildehaus, F.-J.; Eckenweber, F.; Beyer, L.; von Ungern-Sternberg, B.; Bartenstein, P.; Baumann, K.; Dorostkar, M. M.; Rominger, A.; Cumming, P.; Willem, M.; Adelsberger, H.; Herms, J.; Brendel, M.
10.1101/2021.05.30.445761 — neuroscience — Posted on 2021-05-31
63 Differential microRNA expression analyses across two brain regions in Alzheimer's disease
Dobricic, V.; Schilling, M.; Schulz, J.; Zhu, L.-S.; Zhou, C.-W.; Fuss, J.; Franzenburg, S.; Zhu, L.-Q.; Parkkinen, L.; Lill, C. M.; Bertram, L.
10.1101/2021.05.31.446406 — neuroscience — Posted on 2021-05-31
64 Scaling principles of white matter brain connectivity
Ardesch, D. J.; Scholtens, L. H.; de Lange, S. C.; Roumazeilles, L.; Khrapitchev, A. A.; Preuss, T. M.; Rilling, J. K.; Mars, R. B.; van den Heuvel, M. P.
10.1101/2021.05.31.445808 — neuroscience — Posted on 2021-05-31
68 Microfabricated disk technology: rapid scale up in midbrain organoid generation
Mohamed, N.-V.; Lepine, P.; Lacalle-Aurioles, M.; Sirois, J.; Mathur, M.; Reintsch, W.; Beitel, L. K.; Fon, E. A.; Durcan, T. M.
10.1101/2021.05.31.446446 — neuroscience — Posted on 2021-05-31
73 Identification of Pex34p as a component of the peroxisomal de novo biogenesis machinery in yeast
Radke, J.; Nagotu, S.; Girzalsky, W.; Chakraborty, A.; Deckers, M.; Schuldiner, M.; Zalckvar, E.; Erdmann, R.
10.1101/2021.05.31.446392 — cell biology — Posted on 2021-05-31
75 Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine
McMillan, C. L. D.; Choo, J. J. Y.; Idris, A.; Supramaniam, A.; Modhiran, N.; Amarilla, A. A.; Isaacs, A.; Cheung, S. T. M.; Liang, B.; Bielefeldt-Ohmann, H.; Azuar, A.; Acharya, D.; Kelly, G.; Fernando, G. J. P.; Landsberg, M. J.; Khromykh, A. A.; Watterson, D.; Young, P. R.; McMillan, N. A. J.; Muller, D. A.
10.1101/2021.05.30.446357 — microbiology — Posted on 2021-05-31
76 Functional characterization of SARS-CoV-2 vaccine elicited antibodies in immunologically naive and pre-immune humans
Forgacs, D.; Jang, H.; Abreu, R. B.; Hanley, H. B.; Gattiker, J. L.; Jefferson, A. M.; Ross, T. M.
10.1101/2021.05.29.445137 — immunology — Posted on 2021-05-31
77 SARS-CoV-2-specific memory B cells can persist in the elderly despite loss of neutralising antibodies
Jeffery-Smith, A.; Burton, A. R.; Lens, S.; Rees-Spear, C.; Patel, M.; Gopal, R.; Muir, L.; Aiano, F.; Doores, K. J.; Chow, J. Y.; Ladhani, S. N.; Zambon, M.; McCoy, L. E.; Maini, M. K.
10.1101/2021.05.30.446322 — immunology — Posted on 2021-05-31
78 Homemade Bread: Repurposing an Ancient Technology for in vitro Tissue Engineering
Holmes, J. T.; Jaberansari, Z.; Collins, W.; Leblanc Latour, M.; Modulevsky, D. J.; Pelling, A.
10.1101/2020.11.13.353698 — bioengineering — Posted on 2021-05-31
81 Tetracycline exposure alters key gut microbiota in Africanized honey bees (Apis mellifera scutellata x spp.)
Soares, K. O.; Oliveira, C. J.; Rodrigues, A. E.; Vasconcelos, P. C.; Silva, N. M.; Filho, O. G.; Madden, C.; Hale, V. L.
10.1101/2021.05.31.446413 — ecology — Posted on 2021-05-31
84 Escitalopram Administration, Neuroplastic Effects and Relearning: A Diffusion Tensor Imaging Study in Healthy Individuals
Vanicek, T.; Reed, M.; Unterholzner, J.; Kloebl, M.; Godbersen, G. M.; Handschuh, P.; Spurny, B.; Ritter, V.; Gryglewski, G.; Kraus, C.; Winkler, D.; Lanzenberger, R.; Seiger, R.
10.1101/2021.04.25.441324 — neuroscience — Posted on 2021-05-31
85 A model of exercise-induced changes in metabolism, signaling, and gene expression in skeletal muscle
Akberdin, I. R.; Kiselev, I. N.; Pintus, S. S.; Sharipov, R. N.; Vertyshev, A. Y.; Vinogradova, O. L.; Popov, D. V.; Kolpakov, F. A.
10.1101/2021.05.31.446385 — systems biology — Posted on 2021-05-31
92 gcaPDA: A Haplotype-resolved Diploid Assembler
Min, X.; Yang, L.; Jiang, C.; Wu, S.; Luo, C.; Yang, X.; He, L.; Chen, S.; Deng, T.; Ye, M.; Yan, J.; Yang, N.
10.1101/2021.05.31.446328 — genomics — Posted on 2021-05-31
96 An ancient divide in outer membrane tethering systems in Bacteria
Witwinowski, J.; Sartori-Rupp, A.; Taib, N.; Pende, N.; Tham, T. N.; Poppleton, D.; Ghigo, J.-M.; Beloin, C.; Gribaldo, S.
10.1101/2021.05.31.446380 — microbiology — Posted on 2021-05-31
98 Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease
Kenkhuis, B.; Somarakis, A.; Kleindouwel, L. R.; van Roon-Mom, W. M.; Hollt, T.; van der Weerd, L.
10.1101/2021.05.31.446375 — neuroscience — Posted on 2021-05-31
99 Single-Cell Profiling Resolved Transcriptional Alterations and Lineage Dynamics of Subventricular Zone after Mild Traumatic Brain Injury
Chen, X.; Cao, S.; Wang, Y.; Li, M.; Guo, Y.; Ye, Y.; Wang, Z.; Dai, H.; Yang, W.; Sun, Y.; Ou, X.; He, M.; Xie, X.; Liang, W.
10.1101/2021.05.31.446381 — neuroscience — Posted on 2021-05-31
102 Pharmacokinetics of Orally Administered GS-441524 in Dogs
Yan, V. C.; Pham, C.-D.; Yan, M. J.; Yan, A. J.; Khadka, S.; Arthur, K.; Ackroyd, J. J.; Georgiou, D. K.; Roon, L. E.; Bushman, L. R.; Anderson, P. L.; Li, C.; Muller, F. L.
10.1101/2021.02.04.429674 — pharmacology and toxicology — Posted on 2021-05-31
107 Micro-Meta App: an interactive software tool to facilitate the collection of microscopy metadata based on community-driven specifications
Rigano, A.; Ehmsen, S.; Ozturk, S. U.; Ryan, J.; Balashov, A.; Hammer, M.; Kirli, K.; Bellve, K.; Boehm, U.; Brown, C. M.; Chambers, J. J.; Coleman, R. A.; Cosolo, A.; Faklaris, O.; Fogarty, K.; Guilbert, T.; Hamacher, A. B.; Itano, M. S.; Keeley, D. P.; Kunis, S.; Lacoste, J.; Laude, A.; Ma, W.; Marcello, M.; Montero-Llopis, P.; Nelson, G.; Nitschke, R.; Pimentel, J. A.; Weidtkamp-Peters, S.; Park, P. J.; Alver, B.; Grunwald, D.; Strambio-De-Castillia, C.
10.1101/2021.05.31.446382 — bioinformatics — Posted on 2021-05-31
109 The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
Kakihara, K.; Asamizu, K.; Moritsugu, K.; Kubo, M.; Kitaguchi, T.; Endo, A.; Kidera, A.; Ikeguchi, M.; Kato, A.; Komada, M.; Fukushima, T.
10.1101/2021.05.31.446389 — biochemistry — Posted on 2021-05-31
110 Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum
Tani, K.; Kanno, R.; Ji, X.- C.; Hall, M.; Yu, L.- J.; Kimura, Y.; Madigan, M. T.; Mizoguchi, A.; Humbel, B. M.; Wang-Otomo, Z.- Y.
10.1101/2021.05.30.446358 — biochemistry — Posted on 2021-05-31
111 Early Disruption of Photoreceptor Cell Architecture and Loss of Vision in a Humanized Pig Model of Usher Syndrome
Grotz, S.; Schafer, J.; Wunderlich, K. A.; Ellederova, Z.; Auch, H.; Baehr, A.; Runa-Vochozkova, P.; Fadl, J.; Arnold, V.; Ardan, T.; Veith, M.; Santamaria, G.; Dhom, G.; Hitzl, W.; Kessler, B.; Kurome, M.; Zakharchenko, V.; Linnert, J.; Fischer, A.; Blutke, A.; Doering, A.; Suchankova, S.; Popelar, J.; May-Simera, H.; Laugwitz, K.-L.; Vandenberghe, L. H.; Wolf, E.; Nagel-Wolfrum, K.; Motlik, J.; Fischer, M. D.; Wolfrum, U.; Klymiuk, N.
10.1101/2021.05.31.446123 — genetics — Posted on 2021-05-31
115 Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi
Bernatchez, J. A.; Kil, Y.-S.; Barbosa da Silva, E.; Thomas, D.; McCall, L.-I.; Wendt, K. L.; Souza, J. M.; Ackermann, J.; McKerrow, J. H.; Cichewicz, R. H.; Siqueira-Neto, J. L.
10.1101/2021.05.30.446362 — microbiology — Posted on 2021-05-31
116 Epigenetic regulation of innate immune memory in microglia
Zhang, X.; Kracht, L.; Lerario, A. M.; Dubbelaar, M. L.; Brouwer, N.; Wesseling, E. M.; Boddeke, E.; Eggen, B. J. L.; Kooistra, S. M.
10.1101/2021.05.30.446351 — neuroscience — Posted on 2021-05-31
119 Non-coding mutations reveal cancer driver cistromes in luminal breast cancer
El Ghamrasni, S.; Quevedo, R.; Hawley, J. R.; Mazrooei, P.; Hanna, Y.; Cirlan, I.; Zhu, H.; Bruce, J. P.; Oldfield, L. E.; Yang, S. Y. C.; Guilhamon, P.; Reimand, J.; Cescon, D.; Done, S. J.; Lupien, M.; Pugh, T.
10.1101/2021.05.29.446210 — cancer biology — Posted on 2021-05-31
123 An integrative approach leads to the discovery of a novel anti-leukemic peptide from human milk
Chiangjong, W.; Panachan, J.; Vanichapol, T.; Pongsakul, N.; Pongphitcha, P.; Siriboonpiputtana, T.; Lerksuthirat, T.; Nuntnarumit, P.; Supapannachart, S.; Srisomsap, C.; Svasti, J.; Hongeng, S.; Chutipongtanate, S.
10.1101/2021.03.07.434306 — pharmacology and toxicology — Posted on 2021-05-31
124 The genetic and epigenetic landscape of the Arabidopsis centromeres
Naish, M.; Alonge, M.; Wlodzimierz, P.; Tock, A. J.; Abramson, B. W.; Lambing, C. A.; Kuo, P.; Yelina, N.; Hartwick, N.; Colt, K.; Kakutani, T.; Martienssen, R. A.; Bousios, A.; Michael, T. P.; Schatz, M. C.; Henderson, I. R.
10.1101/2021.05.30.446350 — genomics — Posted on 2021-05-31
125 Global analysis of the zinc homeostasis network in Pseudomonas aeruginosa and its gene expression dynamics
Ducret, V.; Abdou, M.; Goncalves Milho, C.; Leoni, S.; Martin--Pelaud, O.; Sandoz, A.; Segovia Campos, I.; Tercier Waeber, M.; Valentini, M.; Perron, K.
10.1101/2021.05.28.446167 — microbiology — Posted on 2021-05-31
127 Quantifying nanotherapeutics penetration using hydrogel based microsystem as a new 3D in-vitro platform
Goodarzi, S.; Prunet, A.; Rossetti, F.; Bort, G.; Tillement, O.; Porcel, E.; Lacombe, S.; Wu, T.-D.; Guerquin-Kern, J.-L.; Delanoë-Ayari, H.; Lux, F.; Riviere, C.
10.1101/2021.01.17.427020 — bioengineering — Posted on 2021-05-31
131 Global analysis of the zinc homeostasis network in Pseudomonas aeruginosa and its gene expression dynamics
Ducret, V.; Abdou, M.; Goncalves Milho, C.; Leoni, S.; Martin--Pelaud, O.; Sandoz, A.; Segovia Campos, I.; Tercier Waeber, M.; Valentini, M.; Perron, K.
10.1101/2021.05.28.446167 — microbiology — Posted on 2021-05-31
132 Influence of age on functional memory T cell diversity
Fang, F.; Cao, W.; Zhu, W.; Lam, N.; Li, L.; Gaddam, S.; Wang, Y.; Kim, C.; Lambert, S.; Zhang, H.; Hu, B.; Farber, D. L.; Weyand, C. M.; Goronzy, J. J.
10.1101/2021.05.29.446296 — immunology — Posted on 2021-05-30
133 Brain virtual histology with X-ray phase-contrast tomography Part II: 3D morphologies of amyloid-β plaques in Alzheimer's disease models
Chourrout, M.; Roux, M.; Boisvert, C.; Gislard, C.; Legland, D.; Arganda-Carreras, I.; Olivier, C.; Peyrin, F.; Boutin, H.; Rama, N.; Baron, T.; Meyronet, D.; Brun, E.; Rositi, H.; Wiart, M.; Chauveau, F.
10.1101/2021.03.25.436908 — neuroscience — Posted on 2021-05-31
134 A genomic link in China roses: and they all lived prickly but water deficient ever after?
Zhong, M.-C.; Jiang, X.-D.; Yang, G.-Q.; Cui, W.-H.; Suo, Z.-Q.; Wang, W.-J.; Sun, Y.-B.; Wang, D.; Cheng, X.-C.; Li, X.-m.; Dong, X.; Tang, K.-X.; Li, D.-Z.; Hu, J.-Y.
10.1101/2020.07.16.207795 — plant biology — Posted on 2021-05-31
135 Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer's disease pathology
Zhang, Z.; Na, H.; Gan, Q.; Tao, Q.; Alekseyev, Y.; Hu, J.; Yan, Z.; Yang, J.; Tian, H.; Zhu, S.; Li, Q.; Rajab, I.; Blusztajn, J.; Wolozin, B.; Emili, A.; Zhang, X.; Stein, T.; Potempa, L.; Qiu, W. Q.
10.1101/2021.05.30.446344 — neuroscience — Posted on 2021-05-30
136 Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models
Bayer, J. M. M.; Dinga, R.; Kia, S. M.; Kottaram, A. R.; Wolfers, T.; Lv, J.; Zalesky, A.; Schmaal, L.; Marquand, A.
10.1101/2021.02.09.430363 — bioinformatics — Posted on 2021-05-30
139 The Evolutionary History of Small RNAs in the Solanaceae
Baldrich, P.; Belanger, S.; Kong, S.; Pokhrel, S.; Tamim, S.; Teng, C.; Schiebout, C.; Gurazada, S. G. R.; Gupta, P.; Patel, P.; Nakano, M.; Dusia, A.; Meyers, B. C.; Frank, M.
10.1101/2021.05.26.445884 — plant biology — Posted on 2021-05-30
140 Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma
Hosein, A. N.; Dangol, G.; Okumura, T.; Roszik, J.; Rajapakshe, K.; Siemann, M.; Ghosh, B.; Monberg, M. E.; Guerrero, P. A.; Zaid, M.; Singhi, A. A.; Haymaker, C. L.; Clevers, H.; Woermann, S. M.; Abou-Elkacem, L.; Maitra, A.
10.1101/2021.05.29.446305 — cancer biology — Posted on 2021-05-30
141 Ankyrin repeats in context with human population variation
Utges, J. S.; Tsenkov, M. I.; Dietrich, N. J.; MacGowan, S. A.; Barton, G. J.
10.1101/2021.05.28.445974 — bioinformatics — Posted on 2021-05-30
145 Obesity-instructed TREM2high macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution
Subramanian, A.; Vernon, K.; Zhou, Y.; Marshall, J.; Alimova, M.; Zhang, F.; Slyper, M.; Waldman, J.; Montesinos, M.; Dionne, D.; Nguyen, L.; Cuoco, M. S.; Dubinsky, D.; Purnell, J.; Keller, K.; Turner, S. H.; Grinkevich, E.; Ghoshal, A.; Weins, A.; Villani, A.-C.; Chang, S.; Rosenblatt-Rosen, O.; Shaw, J. L.; Regev, A.; Greka, A.
10.1101/2021.05.30.446342 — genomics — Posted on 2021-05-30
146 The genetic and epigenetic landscape of the Arabidopsis centromeres
Naish, M. R.; Alonge, M.; Wlodzimierz, P.; Tock, A. J.; Abramson, B. W.; Lambing, C. A.; Kuo, P.; Yelina, N.; Hartwick, N.; Colt, K.; Kakutani, T.; Martienssen, R. A.; Bousios, A.; Michael, T. P.; Schatz, M. C.; Henderson, I. R.
10.1101/2021.05.30.446350 — genomics — Posted on 2021-05-30
148 Cell-autonomous generation of the wave pattern within the vertebrate segmentation clock
Rohde, L. A.; Bercowsky-Rama, A.; Negrete, J.; Valentin, G.; Naganathan, S. R.; Desai, R. A.; Strnad, P.; Soroldoni, D.; Julicher, F.; Oates, A. C.
10.1101/2021.05.29.446196 — developmental biology — Posted on 2021-05-30
155 High Dimensionality Reduction by Matrix Factorization for Systems Pharmacology
Mehrpooya, A.; Saberi-Movahed, F.; Azizizadeh, N.; Rezaei-Ravari, M.; Eftekhari, M.; Tavassoly, I.
10.1101/2021.05.30.446301 — systems biology — Posted on 2021-05-30
156 A global dataset for the projected impacts of climate change on four major crops
Hasegawa, T.; Wakatsuki, H.; Ju, H.; Vyas, S.; Nelson, G. C.; Farrell, A.; Deryng, D.; Meza, F.; Makowski, D.
10.1101/2021.05.27.444762 — plant biology — Posted on 2021-05-30
157 Pseudo-mutant p53 as a targetable phenotype of DNMT3A-mutated pre-leukemia
Tuval, A.; Brilon, Y.; Ezogy, H.; Moskovitz, Y.; Biezuner, T.; Leshkowitz, D.; Salame, T. M.; Minden, M. D.; Tal, P.; Rotter, V.; Oren, M.; Kaushansky, N.; Shlush, L. I.
10.1101/2021.05.30.446347 — cancer biology — Posted on 2021-05-30
160 Landscape of microenvironment in Randall's plaque by single-cell sequencing
Liu, Z.; Duan, X.; Sun, X.; Zhong, J.; Zhong, W.; Yu, B.; Zhao, Z.; Mai, Z.; Liu, H.; Li, S.; Wu, W.; Zeng, G.
10.1101/2021.05.30.444880 — bioinformatics — Posted on 2021-05-30
165 Human genome integration of SARS-CoV-2 contradicted by long-read sequencing
Smits, N.; Rasmussen, J.; Bodea, G. O.; Amarilla, A. A.; Gerdes, P.; Sanchez-Luque, F. J.; Ajjikuttira, P.; Modhiran, N.; Liang, B.; Faivre, J.; Deveson, I. W.; Khromykh, A. A.; Watterson, D.; Ewing, A. D.; Faulkner, G. J.
10.1101/2021.05.28.446065 — genomics — Posted on 2021-05-30
167 Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
Mouri, K.; Guo, M. H.; de Boer, C. G.; Newby, G. A.; Gentili, M.; Liu, D.; Hacohen, N.; Tewhey, R.; Ray, J. P.
10.1101/2021.05.30.445673 — genetics — Posted on 2021-05-30
168 Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR
Scherer, M.; Gasparoni, G.; Rahmouni, S.; Shashkova, T.; Arnoux, M.; Louis, E.; Nostaeva, A.; Avalos, D.; Dermitzakis, E. T.; Aulchenko, Y. S.; Lengauer, T.; Lyons, P. A.; Georges, M.; Walter, J.
10.1101/2021.05.30.445237 — genetics — Posted on 2021-05-30
171 The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
Martin Caballero, L.; Capella, M.; Barrales, R. R.; Dobrev, N.; van Emden, T. S.; Fischer-Burkart, S.; Kinugasa, Y.; Hirano, Y.; Sinning, I.; Fisher, T.; Hiraoka, Y.; Braun, S. J.
10.1101/2021.05.30.446327 — molecular biology — Posted on 2021-05-30
172 Arthropods and the evolution of RNA viruses
Chang, T.; Hirai, J.; Hunt, B. P. V.; Suttle, C. A.
10.1101/2021.05.30.446314 — microbiology — Posted on 2021-05-30
174 The Dual Mechanisms of Cognitive Control dataset: A theoretically-guided within-subject task fMRI battery
Etzel, J. A.; Brough, R.; Freund, M. C.; Kizhner, A.; Lin, Y.; Singh, M. F.; Tang, R.; Tay, A.; Wang, A.; Braver, T. S.
10.1101/2021.05.28.446178 — neuroscience — Posted on 2021-05-30
175 Magnetic Resonance Spectroscopy Frequency and Phase Correction Using Convolutional Neural Networks
Ma, D. J.; Le, H. A.-M.; Ye, Y.; Laine, A. F.; Lieberman, J. A.; Rothman, D. L.; Small, S. A.; Guo, J.
10.1101/2021.05.29.446254 — neuroscience — Posted on 2021-05-30
176 Subcortical brain segmentation in 5-year-old children: validation of FSL-FIRST and FreeSurfer against manual segmentation
Lidauer, K.; Pulli, E. P.; Copeland, A.; Silver, E.; Kumpulainen, V.; Merisaari, H.; Saunavaara, J.; Parkkola, R.; Lahdesmaki, T.; Saukko, E.; Nolvi, S.; Kataja, E.-L.; Karlsson, L.; Karlsson, H.; Tuulari, J. J.
10.1101/2021.05.28.445926 — neuroscience — Posted on 2021-05-30
177 Effect of SSRI discontinuation on anxiety-like behaviours in mice
Collins, H. M.; Pinacho, R.; Ozdemir, D.; Bannerman, D. M.; Sharp, T.
10.1101/2021.05.29.446266 — neuroscience — Posted on 2021-05-30
178 Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition
Blume, T.; Deussing, M.; Biechele, G.; Peters, F.; Zott, B.; Schmidt, C.; Franzmeier, N.; Wind, K.; Eckenweber, F.; Sacher, C.; Shi, Y.; Ochs, K.; Kleinberger, G.; Xiang, X.; Focke, C.; Lindner, S.; Gildehaus, F.-J.; Beyer, L.; von Ungern-Sternberg, B.; Bartenstein, P.; Baumann, K.; Adelsberger, H.; Rominger, A.; Cumming, P.; Willem, M.; Dorostkar, M. M.; Herms, J.; Brendel, M.
10.1101/2021.05.30.446348 — neuroscience — Posted on 2021-05-30
181 FGF21 Response Varies by Sugar Type and is Associated with Body Weight, Dietary Added Sugar, and Neural Signaling in Humans
Yunker, A. G.; Alves, J. M.; Luo, S.; Angelo, B.; DeFendis, A.; Pickering, T. A.; Jann, K.; Monterosso, J. R.; Page, K. A.
10.1101/2021.05.29.446318 — physiology — Posted on 2021-05-30
183 Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
Bhardwaj, T.; Gadhave, K.; Kapuganti, S. K.; Kumar, P.; Brotzakis, Z. F.; Saumya, K. U.; Nayak, N.; Kumar, A.; Garg, N.; Vendruscolo, M.; Giri, R.
10.1101/2021.05.29.446267 — biophysics — Posted on 2021-05-30
188 Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution
Zhao, F.; Yuan, M.; Keating, C.; Shabaani, N.; Limbo, O.; Joyce, C.; Woehl, J.; Barman, S.; Burns, A.; Zhu, X.; Ricciardi, M.; Peng, L.; Smith, J.; Huang, D.; Briney, B.; Sok, D.; Nemazee, D.; Teiijaro, J.; Wilson, I. A.; Burton, D.; Jardine, J. G.
10.1101/2021.05.29.443900 — bioengineering — Posted on 2021-05-30
192 The haplotype-based analysis of Aegilops tauschii introgression into hard red winter wheat and its impact on productivity traits
Nyine, M.; Adhikari, E.; Clinesmith, M.; Aiken, R.; Betzen, B.; wang, w.; Davidson, D.; Yu, Z.; Guo, Y.; He, F.; Akhunov, A.; Jordan, K. W.; Fritz, A. K.; Akhunov, E.
10.1101/2021.05.29.446303 — genetics — Posted on 2021-05-30
193 Dissecting the loci underlying maturation timing in Atlantic salmon using haplotype and multi-SNP based association methods
Sinclair-Waters, M.; Nome, T.; Wang, J.; Lien, S.; Kent, M. P.; Saegrov, H.; Floro-Larsen, B.; Bolstad, G. H.; Primmer, C. R.; Barson, N. J.
10.1101/2021.05.28.446127 — evolutionary biology — Posted on 2021-05-30
195 Ocellar spatial vision in Myrmecia ants
Penmetcha, B.; Ogawa, Y.; Ryan, L. A.; Hart, N. S.; Narendra, A.
10.1101/2021.05.28.446117 — evolutionary biology — Posted on 2021-05-30
197 ILORA: A database of alien vascular flora of India
Pant, V.; Patwardhan, C.; Patil, K.; Bhowmick, A. R.; Mukherjee, A.; Banerjee, A. K.
10.1101/2021.05.28.446252 — ecology — Posted on 2021-05-30
199 Influence of age on functional memory T cell diversity
Fang, F.; Cao, W.; Zhu, W.; Lam, N.; Li, L.; Gaddam, S.; Wang, Y.; Kim, C.; Lambert, S.; Zhang, H.; Hu, B.; Farber, D. L.; Weyand, C. M.; Goronzy, J. J.
10.1101/2021.05.29.446296 — immunology — Posted on 2021-05-30
205 Denoising-based Image Compression for Connectomics
Minnen, D.; Januszewski, M.; Shapson-Coe, A.; Schalek, R. L.; Balle, J.; Lichtman, J. W.; Jain, V.
10.1101/2021.05.29.445828 — neuroscience — Posted on 2021-05-30
206 Effect sizes and test-retest reliability of the fMRI-based Neurologic Pain Signature
Han, X.; Ashar, Y. K.; Kragel, P.; Petre, B.; Schelkun, V.; Atlas, L.; Chang, L. J.; Jepma, M.; Koban, L.; Losin, E. R.; Roy, M.; Woo, C.-W.; Wager, T. D.
10.1101/2021.05.29.445964 — neuroscience — Posted on 2021-05-30
208 Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
Arunachalam Chandran, V.; Pliatsikas, C.; Neufeld, J.; O'Connell, G.; Haffey, A.; DeLuca, V.; Chakrabarti, B.
10.1101/2021.05.29.446259 — neuroscience — Posted on 2021-05-30
210 Apical Actin-myosin Network Regulates the Tight Junction of Polarized Madin-Darby Canine Kidney Cells
Lu, C.-h.; Wen, F.-l.; Hsueh, S. C.-C.; Wu, W.-h.; Lin, Y.-F.; Prouveur, M.; Boudier, T.; Lin, K.-h.
10.1101/2021.05.30.446323 — biophysics — Posted on 2021-05-30
212 Federated Multi-Site Normative Modeling using Hierarchical Bayesian Regression
Kia, S. M.; Huijsdens, H.; Rutherford, S.; Dinga, R.; Wolfers, T.; Mennes, M.; Andreassen, O.; Westlye, L. T.; Beckmann, C. F.; Marquand, A. F.
10.1101/2021.05.28.446120 — bioinformatics — Posted on 2021-05-30
214 Variomes: a high recall search engine to support the curation of genomic variants
Pasche, E.; Mottaz, A.; Caucheteur, D.; Gobeill, J.; Michel, P.-A.; Ruch, P.
10.1101/2021.05.29.446224 — bioinformatics — Posted on 2021-05-30
215 Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry
Rubinoff, I.; Kuranov, R. V.; Ghassabi, Z.; Wang, Y.; Beckmann, L.; Miller, D. A.; Tayebi, B.; Wollstein, G.; Ishikawa, H.; Schuman, J. S.; Zhang, H. F.
10.1101/2021.05.28.446197 — bioengineering — Posted on 2021-05-30
216 Decentralizing cell-free RNA sensing with the use of low-cost cell extracts
Arce, A.; Guzman, F.; Gandini, C.; Puig, J.; Matute, T.; Haseloff, J.; Dalchau, N.; Molloy, J.; Pardee, K.; Federici, F.
10.1101/2021.05.29.446205 — bioengineering — Posted on 2021-05-30
220 Genetic Dissection of the RNA Polymerase II Transcription Cycle
Chou, S.-P.; Alexander, A. K.; Rice, E. J.; Choate, L. A.; Cohen, P. E.; Danko, C. G.
10.1101/2021.05.23.445279 — genomics — Posted on 2021-05-30
221 Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25
Haubrich, K.; Augsten, S.; Alvarez, L.; Huppertz, I.; Simon, B.; Perez, K.; Masiewicz, P.; Lethier, M.; Rittinger, K.; Gabel, F.; Hentze, M. W.; Cusack, S.; Hennig, J.
10.1101/2020.05.04.070177 — molecular biology — Posted on 2021-05-30
222 Fluorescence-Activated Droplet Sorting of Polyethylene terephthalate-degrading Enzymes
Qiao, Y.; Hu, R.; Chen, D.; Wang, L.; Fu, Y.; Li, C.; Dong, Z.; Weng, Y.; Du, W.
10.1101/2021.05.12.443719 — microbiology — Posted on 2021-05-30
223 Resolving the molecular architecture of the photoreceptor active zone by MINFLUX nanoscopy
Grabner, C.; Jansen, I.; Neef, J.; Weiss, T.; Schmidt, R.; Riedel, D.; Wurm, C. A.; Moser, T.
10.1101/2021.05.28.446138 — neuroscience — Posted on 2021-05-30
224 A connectomic study of a petascale fragment of human cerebral cortex
Shapson-Coe, A.; Januszewski, M.; Berger, D. R.; Pope, A.; Wu, Y.; Blakely, T.; Schalek, R. L.; Li, P.; Wang, S.; Maitlin-Shepard, J.; Karlupia, N.; Dorkenwald, S.; Sjostedt, E.; Leavitt, L.; Lee, D.; Bailey, L.; Fitzmaurice, A.; Kar, R.; Field, B.; Wu, H.; Wagner-Carena, J.; Aley, D.; Lau, J.; Lin, Z.; Wei, D.; Pfister, H.; Peleg, A.; Jain, V.; Lichtman, J. W.
10.1101/2021.05.29.446289 — neuroscience — Posted on 2021-05-30
227 Revision of the genus Dichaetophora Duda (Diptera: Drosophilidae), part I: DNA bar-coding and molecular phylogenetic reconstruction
Katoh, T. K.; Chen, J.-M.; Yang, J.-H.; Zhang, G.; Wang, L.; Suwito, A.; Toda, M. J.; Zhang, Y.-P.; Gao, J.-J.
10.1101/2021.05.28.446102 — zoology — Posted on 2021-05-30
231 Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
Ham, D. J.; Boersch, A.; Chojnowska, K.; Lin, S.; Leuchtmann, A. B.; Ham, A. S.; Thuerkauf, M.; Delezie, J.; Furrer, R.; Burri, D.; Sinnreich, M.; Handschin, C.; Tintignac, L. A.; Zavolan, M.; Mittal, N.; Ruegg, M. A.
10.1101/2021.05.28.446097 — physiology — Posted on 2021-05-30
233 Colicin E1 opens its hinge to plug TolC
Budiardjo, S. J.; Stevens, J. J.; Calkins, A. L.; Ikujuni, A. P.; Wimalasena, V. K.; Firlar, E.; Case, D.; Biteen, J. S.; Kaelber, J.; Slusky, J. S. G.
10.1101/692251 — biophysics — Posted on 2021-05-29
236 Unbiased screen of human transcriptome reveals an unexpected role of 3'UTRs in translation initiation
Wang, Z.; Yang, Y.; Fan, X.; Ye, Y.; Chen, C.; Ludwig, S. E. J.; Zhang, S.; Lu, Q.; Will, C. L.; Urlaub, H.; Sun, J.; Lu?hrmann, R.
10.1101/2021.05.28.446092 — molecular biology — Posted on 2021-05-29
237 Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
Chipman, P. H.; Pazo Fernandez, A.; Fung, C. C. A.; Tedoldi, A.; Kawai, A.; Ghimire Gautam, S.; Kurosawa, M.; Abe, M.; Sakimura, K.; Fukai, T.; Goda, Y.
10.1101/2021.05.28.446253 — neuroscience — Posted on 2021-05-29
240 Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo
Graf, J.; Rahmati, V.; Majoros, M.; Witte, O. W.; Geis, C.; Kiebel, S. J.; Holthoff, K.; Kirmse, K.
10.1101/2021.05.28.446133 — neuroscience — Posted on 2021-05-29
241 Dissecting Functional, Structural, and Molecular Requirements for Serotonin Release from Mouse Enterochromaffin Cells
Shaaban, A.; Maass, F.; Schwarze, V.; Lund, M. L.; Beuermann, S.; Chan, M.; Harenberg, C.; Bewick, G. A.; Keating, D. J.; Benseler, F.; Cooper, B. H.; Imig, C.
10.1101/2021.05.28.446100 — neuroscience — Posted on 2021-05-29
242 Oligodendrocyte precursor cells prune axons in the mouse neocortex
Buchanan, J.; Elabaddy, L.; Collman, F.; Jorstad, N. L.; Bakken, T. E.; Ott, C.; Glatzer, J.; Bleckert, A. A.; Bodor, A. L.; Brittan, D.; Bumbarger, D. J.; Mahalingam, G.; Seshamani, S.; Schneider-Mizell, C. M.; Takeno, M. M.; Torres, R.; Yin, W.; Hodge, R. D.; Castro, M.; Dorkenwald, S.; Ih, D.; Jordan, C. S.; Kemnitz, N.; Lee, K.; Lu, R.; Macrina, T.; Mu, S.; Popovych, S.; Silversmith, W. M.; Tartavull, I.; Turner, N. L.; Wilson, A. M.; Wong, W.; Wu, J.; Zlateski, A.; Zung, J.; Lippincott-Schwartz, J.; Lein, E. S.; Seung, H. S.; Bergles, D. E.; Reid, R. C.; Macarico da Costa, N.
10.1101/2021.05.29.446047 — neuroscience — Posted on 2021-05-29
244 Profiling tumor immune microenvironment of non-small cell lung cancer using multiplex immunofluorescence
Peng, H.; Wu, X.; Zhong, R.; Yu, T.; Cai, X.; Liu, J.; Wen, Y.; Ao, Y.; Chen, J.; Li, Y.; Zheng, H.; Chen, Y.; Pan, Z.; He, J.; Liang, W.
10.1101/2021.05.28.446005 — cancer biology — Posted on 2021-05-29
246 Multi-Omics Analysis of Fibroblasts from the Invasive Tumor Edge Reveals that Tumor-Stroma Crosstalk Induces O-glycosylation of the CDK4-pRB Axis
Bouchard, G.; Marques, F. J. G.; Karacosta, L. G.; Zhang, W.; Bermudez, A.; Riley, N. M.; Mehl, L. C.; Benson, J. A.; Shrager, J. B.; Bertozzi, C. R.; Pitteri, S.; Giaccia, A. J.; Plevritis, S. K.
10.1101/2021.05.28.446229 — cancer biology — Posted on 2021-05-29
247 Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3
Masgras, I.; Cannino, G.; Ciscato, F.; Sanchez-Martin, C.; Pizzi, M.; Menga, A.; Castegna, A.; Rasola, A.
10.1101/2021.05.29.446262 — cancer biology — Posted on 2021-05-29
249 Strategy for detecting off-target sites in genome-edited rice
Narushima, J.; Kimata, S.; Shiwa, Y.; Gondo, T.; Akimoto, S.; Soga, K.; Yoshiba, S.; Nakamura, K.; Shibata, N.; Kondo, K.
10.1101/2021.05.28.446070 — bioinformatics — Posted on 2021-05-29
251 A robust approach to estimate relative phytoplankton cell abundance from metagenomic data
Pierella Karlusich, J. J.; Pelletier, E.; Zinger, L.; Lombard, F.; Zingone, A.; Colin, S.; Gasol, J. M.; Dorrell, R.; Scalco, E.; Acinas, S. G.; Wincker, P.; de Vargas, C.; Bowler, C.
10.1101/2021.05.28.446125 — ecology — Posted on 2021-05-29
253 Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites
Warren, W. C.; Akopyants, N.; Dobson, D. E.; Hertz-Fowler, C.; Lye, L.-F.; Myler, P. J.; Ramasamy, G.; Shanmugasundram, A.; Silva-Franco, F.; Tomlinson, C.; Wilson, R. K.; Beverley, S. M.
10.1101/2021.05.29.446295 — microbiology — Posted on 2021-05-29
254 Strain-level variation influences Methanothermococcus fitness in marine hydrothermal systems
Hoffert, M.; Anderson, R. E.; Reveillaud, J.; Murphy, L.; Stepanauskas, R.; Huber, J. A.
10.1101/2021.05.29.446292 — microbiology — Posted on 2021-05-29
255 Synthetic Antigen Presenting cells reveal the diversity and functional specialization of extracellular vesicles composing the fourth signal of T cell immunological synapses.
Cespedes, P. F.; Jainarayanan, A. K.; Fernandez-Messina, L.; Valvo, S.; Saliba, D. G.; Kvalvaag, A.; Kurz, E.; Colin-York, H.; Fritzsche, M.; Yanchun, P.; Dong, T.; Siller-Farfan, J. A.; Dushek, O.; Maj, M.; Sezgin, E.; Peacock, B.; Law, A.; Aubert, D.; Engledow, S.; Attar, M.; Sanchez-Madrid, F.; Hester, S.; Fisher, R.; Dustin, M. L.
10.1101/2021.05.29.445691 — immunology — Posted on 2021-05-29
256 A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation
Jackson, C. M.; Demmert, M.; Mukherjee, S.; Isaacs, T.; Gray, J.; Senthamaraikannan, P.; Presicce, P.; Chetal, K.; Salomonis, N.; Miller, L. A.; Jobe, A. H.; Kallapur, S. G.; Zacharias, W. J.; Lewkowich, I. P.; Deshmukh, H.; Chougnet, C. A.
10.1101/2021.05.28.444219 — immunology — Posted on 2021-05-29
257 Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures
Dhanwani, R.; Rodrigues Lima-Junior, J.; Sethi, A.; Pham, J.; Williams, G.; Frazier, A.; Xu, Y.; Amara, A. W.; Standaert, D. G.; Goldman, J. G.; Litvan, I.; Alcalay, R. N.; Peters, B.; Sulzer, D.; Lindestam Arlehamn, C. S.; Sette, A.
10.1101/2021.05.28.446215 — immunology — Posted on 2021-05-29
261 A suitable murine model for studying respiratory coronavirus infection and therapeutic countermeasures in BSL-2 laboratories
Andrade, A. C. d. S. P.; Campolina-Silva, G. H.; Queiroz-Junior, C. M.; de Oliveira, L. C.; Lacerda, L. d. S. B.; Pimenta, J. C.; de Souza, F. R. O.; Chaves, I. d. M.; Passos, I. B.; Teixeira, D. C.; Bittencourt-Silva, P. G.; Valadao, P. A. C.; Rossi-Oliveira, L.; Antunes, M. M.; Figueiredo, A. F. A.; Wnuk, N. T.; Temerozo, J. R.; Ferreira, A. C.; Cramer, A.; Oliveira, C. A.; Duraes-Carvalho, R.; Arns, C. W.; Guimaraes, P. P. G.; Costa, G. M. J.; Menezes, G. B. d.; Guatimosim, C.; Silva, G. S. F. d.; Souza, T. M. L.; Barrioni, B. R.; Pereira, M. d. M.; Sousa, L. P. d.; Teixeira, M. M.; Costa,
10.1101/2021.05.28.446200 — microbiology — Posted on 2021-05-29
263 Genome of the giant panda roundworm illuminates its host shift and parasitic adaptation
Xie, Y.; Wang, S.; Wu, S.; Gao, S.; Meng, Q.; Wang, C.; Lai, J.; Luo, L.; Zhou, X.; Xu, J.; Gu, X.; He, R.; Yang, Z.; Peng, X.; Hu, S.; Yang, G.
10.1101/2021.05.29.446263 — genomics — Posted on 2021-05-29
269 Label-free imaging of membrane potentials by intramembrane field modulation, assessed by Second Harmonic Generation Microscopy
de Coene, Y.; Jooken, S.; Deschaume, O.; Van Steenbergen, V.; Vanden Berghe, P.; Van den Haute, C.; Baekelandt, V.; Callewaert, G.; Van Cleuvenbergen, S.; Verbiest, T.; Bartic, C.; Clays, K.
10.1101/2021.05.28.446105 — biophysics — Posted on 2021-05-29
270 StrainGE: A toolkit to track and characterize low-abundance strains in complex microbial communities
van Dijk, L. R.; Walker, B. J.; Straub, T. J.; Worby, C.; Grote, A.; Schreiber, H. L.; Anyansi, C.; Pickering, A.; Hultgren, S. J.; Manson, A. L.; Abeel, T.; Earl, A. M.
10.1101/2021.02.14.431013 — bioinformatics — Posted on 2021-05-29
271 Triangulation of microbial fingerprinting in anaerobic digestion reveals consistent fingerprinting profiles
De Vrieze, J.; Heyer, R.; Props, R.; Van Meulenbroek, L.; Gille, K.; Vanhaecke, L.; Benndorf, D.; Boon, N.
10.1101/2021.05.28.446109 — bioengineering — Posted on 2021-05-29
273 Genomic characterization of world's longest selection experiment in mouse reveals the complexity of polygenic traits.
Palma-Vera, S. E.; Reyer, H.; Langhammer, M.; Reinsch, N.; Derezanin, L.; Fickel, J.; Qanbari, S.; Weitzel, J.; Franzenburg, S.; Hemmrich-Stanisak, G.; Schoen, J.
10.1101/2021.05.28.446207 — genomics — Posted on 2021-05-29
276 A Role for Synaptonemal Complex in Meiotic Mismatch Repair
Voelkel-Meiman, K.; Oke, A.; Feil, A.; Shames, A.; Fung, J.; MacQueen, A. J.
10.1101/2021.05.28.446251 — genetics — Posted on 2021-05-29
277 Sialoglycan microarray encoding reveals differential sialoglycan binding of phylogenetically-related bacterial AB5 toxin B subunits
Sasmal, A.; Khan, N.; Khedri, Z.; Kellman, B. P.; Srivastava, S.; Verhagen, A.; Yu, H.; Bruntse, A. B.; Diaz, S.; Varki, N.; Beddoe, T.; Paton, A. W.; Paton, J. C.; Chen, X.; Lewis, N. E.; Varki, A.
10.1101/2021.05.28.446191 — molecular biology — Posted on 2021-05-29
279 Multi-dimensional analyses identify genes of high priority for pancreatic cancer research
Nwosu, Z. C.; Giza, H.; Nassif, M.; Charlestin, V.; Menjivar, R. E.; Kim, D.; Kemp, S.; Steele, N.; Hu, J.; Hu, B.; Wang, S.; Pasca di Magliano, M.; Lyssiotis, C. A.
10.1101/2021.05.28.446056 — cancer biology — Posted on 2021-05-29
280 Raabin-WBC: a large free access dataset of white blood cells from normal peripheral blood
Mousavi Kouzehkanan, Z.; Saghari, S.; Tavakoli, E.; Rostami, P.; AbbasZadeh, M.; Mirzadeh, F.; Shahabi Satlsar, E.; Gheidishahran, M.; Gorgi, F.; Mohammadi, S.; Hosseini, R.
10.1101/2021.05.02.442287 — bioengineering — Posted on 2021-05-29
284 In-field genetic stock identification of overwintering coho salmon in the Gulf of Alaska: Evaluation of Nanopore sequencing for remote real-time deployment
Deeg, C. M.; Sutherland, B. J. G.; Ming, T. J.; Wallace, C.; Jonsen, K.; Flynn, K. L.; Rondeau, E. B.; Beacham, T. D.; Miller, K. M.
10.1101/2021.05.27.445905 — genetics — Posted on 2021-05-29
286 Tightly constrained genome reduction and relaxation of purifying selection during secondary plastid endosymbiosis
uthanumallian, k.; Iha, C.; Repetti, S. I.; Chan, C. X.; Bhattacharya, D.; Duchene, S.; Verbruggen, H.
10.1101/2021.05.27.446077 — evolutionary biology — Posted on 2021-05-29
293 Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor
Cong, Z.; Chen, L.-N.; Ma, H.; Zhou, Q.; Zou, X.; Ye, C.; Dai, A.; Liu, Q.; Huang, W.; Sun, X.; Wang, X.; Xu, P.; Zhao, L.; Xia, T.; Zhong, W.; Yang, D.; Xu, H. E.; Zhang, Y.; Wang, M.-W.
10.1101/2021.05.29.446269 — molecular biology — Posted on 2021-05-29
296 Revealing conserved mechanisms of neurodegeneration in a colonial chordate
Anselmi, C.; Kowarsky, M.; Gasparini, F.; Caicci, F.; Ishizuka, K. J.; Palmeri, K. J.; Sinha, R. A.; Neff, N.; Quake, S. R.; Weissman, I. L.; Voskoboynik, A.; Manni, L.
10.1101/2021.05.27.446068 — neuroscience — Posted on 2021-05-29
297 Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury
Fiore, N. T.; Yin, Z.; Guneykaya, D.; Gauthier, C. D.; Hayes, J.; DHary, A.; Butovsky, O.; Moalem-Taylor, G.
10.1101/2021.05.27.446082 — neuroscience — Posted on 2021-05-29
298 A global dataset for the projected impacts of climate change on four major crops
Hasegawa, T.; Wakatsuki, H.; Ju, H.; Vyas, S.; Nelson, G. C.; Farrell, A.; Deryng, D.; Meza, F.; Makowski, D.
10.1101/2021.05.27.444762 — plant biology — Posted on 2021-05-29
299 Subcutaneous infusion of neurosecretory protein GL promotes fat accumulation in mice
Narimatsu, Y.; Fukumura, K.; Iwakoshi-Ukena, E.; Mimura, A.; Furumitsu, M.; Ukena, K.
10.1101/2021.05.27.446062 — physiology — Posted on 2021-05-29
300 A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ
Lam, J.; Biete, M.; Mungai, M.; AshShareef, S.; Neikirk, K.; Garza Lopez, E.; Christensen, T. A.; Salisbury, J. L.; Katti, P.; Glancy, B.; Pereira, R. O.; Abel, E. D.; Hinton, A.
10.1101/2021.05.27.446036 — biophysics — Posted on 2021-05-29
301 Molecular basis for kinin selectivity and activation of the human bradykinin receptors
Yin, Y.-L.; Ye, C.; Zhou, F.; Wang, J.; Yang, D.; Yin, W.; Wang, M.-W.; Xu, H. E.; Jiang, Y.
10.1101/2021.05.27.446069 — biophysics — Posted on 2021-05-29
302 Systematic evaluation of NIPT aneuploidy detection software tools with clinically validated NIPT samples
Paluoja, P.; Teder, H.; Ardeshirdavani, A.; Bayindir, B.; Vermeesch, J. R.; Salumets, A.; Krjutskov, K.; Palta, P.
10.1101/2021.05.27.445941 — bioinformatics — Posted on 2021-05-29
303 Widespread occurrence of hybrid internal-terminal exons in human transcriptomes
Fiszbein, A.; McGurk, M.; Calvo-Roitberg, E.; Kim, G.; Burge, C.; Pai, A. A.
10.1101/2021.05.27.446076 — bioinformatics — Posted on 2021-05-29
304 RNA folding using quantum computers
Fox, D. M.; MacDermaid, C. M.; Schreij, A. M. A.; Zwierzyna, M. A.; Walker, R. C.
10.1101/2021.05.27.446060 — bioinformatics — Posted on 2021-05-29
305 Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
Petrigliano, F. A.; Liu, N. Q.; Lee, S.; Tassey, J.; Sarkar, A.; Lin, Y.; Li, L.; Yu, Y.; Geng, D.; Zhang, J.; Shkhyan, R.; Bogdanov, J.; Van Handel, B.; Ferguson, G. B.; Lee, Y.; Hinderer, S.; Tseng, K.-C.; Kavanaugh, A.; Crump, J. G.; Pyle, A. D.; Schenke-Layland, K.; Billi, F.; Wang, L.; Lieberman, J.; Hurtig, M.; Evseenko, D.
10.1101/2021.05.27.446024 — bioengineering — Posted on 2021-05-29
309 Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
Fernandez-Rhodes, L.; Graff, M.; Buchanan, V. L.; Justice, A. E.; Highland, H. M.; Guo, X.; Young, K. L.; Adhikari, K.; Allred, N. P.; Below, J. E.; Bradfield, J.; Pereira, A. C.; Glover, L.; Kim, D.; Lilly, A. G.; Shrestha, P.; Thomas, A. G.; Zhang, X.; Chen, M.; Chiang, C.; Pulit, S.; Horimoto, A.; Krieger, J. E.; Guindo-Martinez, M.; Preuss, M.; Schumann, C.; Smit, R. A. J.; Torres-Mejia, G.; Acuna-Alonzo, V.; Bedoya, G.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo, C.; Gonzalez-Jose, R.; Poletti, G.; Rothhammer, F.; Hakonarson, H.; Adler, S. G.; Igo, R.; Iyengar, S.; Nicholas, S. B.;
10.1101/2021.05.27.445969 — genetics — Posted on 2021-05-29
310 Diverse mating phenotypes impact the spread of wtf meiotic drivers in S. pombe
Zanders, S. E.; Lopez Hernandez, J. F.; Helston, R. M.; Lange, J. J.; Billmyre, R. B.; Schaffner, S. H.; Eickbush, M. T.; McCroskey, S.
10.1101/2021.05.28.446231 — evolutionary biology — Posted on 2021-05-29
311 RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells.
DURAND, S.; BRUELLE, M.; BOURDELAIS, F.; BENNYCHEN, B.; BLIN-GONTHIER, J.; ISAAC, C.; HUYGHE, A.; SEYVE, A.; VANBELLE, C.; MEYRONET, D.; CATEZ, F.; DIAZ, J. J.; Lavial, F.; Ricci, E. P.; DUCRAY, F.; GABUT, M.
10.1101/2021.05.27.443845 — developmental biology — Posted on 2021-05-29
312 BRD9-containing non-canonical BAF complexes safeguard cell identity and prevent reprogramming
Sevinc, K.; Gürhan Sevinc, G.; Cavga, A. D.; Philpott, M.; Kelekci, S.; Can, H.; Cribbs, A. P.; Ayar, E. S.; Arabacı, D. H.; Dunford, J. P.; Demir, A. B.; Sigua, L.; Qi, J.; Oppermann, U.; Önder, T. T.
10.1101/2021.05.27.445940 — developmental biology — Posted on 2021-05-29
313 TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and human
Burns, A. J.; Delalande, J. M.; Nagy, N.; McCann, C. J.; Natarajan, D.; Cooper, J. E.; Carreno, G.; Dora, D.; Campbell, A.; Laurent, N.; Kemos, P.; Thomas, S.; Alby, C.; Attie-Bitach, T.; Lyonnet, S.; Logan, M. P. O.; Goldstein, A. M.; Davey, M. G.; Hofstra, R. M. W.; Thapar, N.
10.1101/2021.05.28.446103 — developmental biology — Posted on 2021-05-29
314 Subepithelial Myofibroblasts Are Critical Regulators of Intestinal Epithelial Restoration
Fernandez-Majada, V.; Comelles, J.; Acevedo, V.; Abad-Lazaro, A.; Hernando-Momblona, X.; Batlle, E.; Elena Martinez, E.
10.1101/2021.05.28.446131 — cell biology — Posted on 2021-05-29
315 L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation
Castejon-Vega, B.; Rubio, A.; Perez-Pulido, A. J.; Quiles, J. L.; Lane, J. D.; Fernandez Dominguez, B.; Cachon-Gonzalez, M. B.; Martin.Ruiz, C.; Sanz, A.; Cox, T. M.; Alcocer-Gomez, E.; Cordero, M. D.
10.1101/2021.05.28.446132 — cell biology — Posted on 2021-05-29
316 A novel bacteriophage with broad host-range against Clostridioides difficile ribotype 078 elucidates the phage receptor.
Whittle, M. J.; Bilverstone, T. W.; van Esveld, R. J.; Lücke, A. C.; Lister, M. M.; Kuehne, S.; Minton, N. P.
10.1101/2021.05.26.445907 — microbiology — Posted on 2021-05-29
317 Host factors drive the within-host competition between highly and low pathogenic H5N8 avian influenza viruses
Bessiere, P.; Figueroa, T.; Coggon, A.; Foret-Lucas, C.; Houffschmitt, A.; Fusade-Boyer, M.; Dupre, G.; Guerin, J.-L.; Delverdier, M.; Volmer, R.
10.1101/2021.04.06.438580 — microbiology — Posted on 2021-05-29
318 A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging
Soch, J.; Richter, A.; Schütze, H.; Kizilirmak, J. M.; Assmann, A.; Behnisch, G.; Feldhoff, H.; Fischer, L.; Heil, J.; Knopf, L.; Merkel, C.; Raschick, M.; Schietke, C. J.; Schult, A.; Seidenbecher, C. I.; Yakupov, R.; Ziegler, G.; Wiltfang, J.; Düzel, E.; Schott, B. H.
10.1101/2021.01.16.426666 — neuroscience — Posted on 2021-05-29
319 Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease
Raval, N. R.; Gudmundsen, F.; Juhl, M.; Videbaek, A.; Petersen, I. N.; Mikkelsen, J. D.; Fisher, P. M.; Plaven-Sigray, P.; Knudsen, G. M.; Palner, M.
10.1101/2021.05.27.444950 — neuroscience — Posted on 2021-05-29
320 GIGANTEA gene expression influence leaf senescence in Populus in two different ways
Fataftah, N.; Bag, P.; Andre, D.; Lihavainen, J.; Zhang, B.; Ingvarsson, P. K.; Nilsson, O.; Jansson, S.
10.1101/2021.05.28.446188 — plant biology — Posted on 2021-05-29
321 The Evolutionary History of Small RNAs in the Solanaceae
Baldrich, P.; Belanger, S.; Kong, S.; Pokhrel, S.; Tamin, S.; Teng, C.; Schiebout, C.; Gurazada, S. G. R.; Gupta, P.; Patel, P.; Nakano, M.; Dusia, A.; Meyers, B. C.; Frank, M.
10.1101/2021.05.26.445884 — plant biology — Posted on 2021-05-29
322 New fossils of Australopithecus sediba reveal a nearly complete lower back
Williams, S. A.; Prang, T. C.; Meyer, M. R.; Nalley, T. K.; Van Der Merwe, R.; Yelverton, C.; Garcia-Martinez, D.; Russo, G. A.; Ostrofsky, K. R.; Eyre, J.; Grabowski, M.; Nalla, S.; Bastir, M.; Schmid, P.; Churchill, S. E.; Berger, L. R.
10.1101/2021.05.27.445933 — paleontology — Posted on 2021-05-29
324 Neural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence
Rossi, A.; Coum, A.; Madelenat, M.; Harris, L.; Miedzik, A.; Strohbuecker, S.; Chai, A.; Fiaz, H.; Chaouni, R.; Faull, P.; Grey, W.; Bonnet, D.; Hamid, F.; Makeyev, E. V.; Snijders, A. P.; Kelly, G.; Guillemot, F.; Sousa-Nunes, R.
10.1101/2021.01.06.425462 — developmental biology — Posted on 2021-05-29
325 Metabolic design in a model of extreme mammalian metabolism, the North American least shrew (Cryptotis parva)
Chung, D. J.; Madison, G. P.; Aponte, A. M.; Singh, K.; Li, Y.; Pirooznia, M.; Bleck, C. K. E.; Darmani, N. A.; Balaban, R. S.
10.1101/2021.05.28.446190 — zoology — Posted on 2021-05-29
328 An early signaling transcription factor regulates differentiation in Giardia
Shih, H.-W.; Alas, G. C. M.; Rydell, D. S.; Zhang, B.; Hamilton, G. A.; Paredez, A. R.
10.1101/2021.05.27.446072 — developmental biology — Posted on 2021-05-28
330 Short- and long-term effects of amoxicillin/clavulanic acid or doxycycline on the gastrointestinal microbiome of growing cats
Stavroulaki, E.; Suchodolski, J. S.; Pilla, R.; Fosgate, G. T.; Sung, C.-H.; Lidbury, J. A.; Steiner, J. M.; Xenoulis, P. G.
10.1101/2021.05.28.446115 — microbiology — Posted on 2021-05-28
331 Global analysis of the zinc homeostasis network in Pseudomonas aeruginosa and its gene expression dynamics
Ducret, V.; Abdou, M.; Goncalves Milho, C.; Leoni, S.; Martin--Pelaud, O.; Sandoz, A.; Segovia Campos, I.; Tercier Waeber, M.; Valentini, M.; Perron, K.
10.1101/2021.05.28.446167 — microbiology — Posted on 2021-05-28
333 Reconstruction of metagenome-assembled genomes from aquaria
Ettinger, C. L.; Bryan, J.; Tokajian, S. T.; Jospin, G.; Coil, D. A.; Eisen, J. A.
10.1101/2021.05.28.446213 — microbiology — Posted on 2021-05-28
334 Distinct cellular immune signatures in acute Zika virus infection are associated withhigh or low persisting neutralizing antibody titers
McCarthy, E. E.; Odorizzi, P. M.; Lutz, E.; Smullin, C. P.; Tenvooren, I.; Stone, M.; Simmons, G.; Hunt, P. W.; Feeney, M. E.; Norris, P. J.; Busch, M. P.; Spitzer, M. H.; Rutishauser, R. L.
10.1101/2021.05.27.446054 — immunology — Posted on 2021-05-28
337 A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk
Grotz, A. K.; Navarro-Guerrero, E.; Bevacqua, R. J.; Baronio, R.; Thomsen, S. K.; Nawaaz, S.; Rajesh, V.; Wesolowska-Andersen, A.; Kem, S. K.; Ebner, D.; Gloyn, A. L.
10.1101/2021.05.28.445984 — genomics — Posted on 2021-05-28
338 Zones of Cellular Damage Around Pulsed-Laser Wounds
O'Connor, J.; Akbar, F. B.; Hutson, M. S.; Page-McCaw, A.
10.1101/2021.05.28.446116 — cell biology — Posted on 2021-05-28
342 The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate
Gee, S.; Chandiramani, M.; Seow, J.; Modestini, C.; Das, A.; Doores, K. J.; Tribe, R. M.; Gibbons, D. L.
10.1101/2021.05.27.446014 — immunology — Posted on 2021-05-28
343 Differences in social brain function in autism spectrum disorder are linked to the serotonin transporter
Wong, N. M. L.; Dipasquale, O.; Turkheimer, F. E.; Findon, J. L.; Wichers, R. H.; Dimitrov, M.; Murphy, C. M.; Stoencheva, V.; Robertson, D. M.; Murphy, D. G.; Daly, E.; McAlonan, G. M.
10.1101/2021.05.28.446151 — neuroscience — Posted on 2021-05-28
349 DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks
Venugopal, K.; Nowialis, P.; Feng, Y.; Shabashvili, D. E.; Berntsen, C. M.; Krajcik, K. I.; Taragjini, C.; Zaroogian, Z.; Casellas-Roman, H. L.; Posada, L. M.; Gunaratne, C.; Li, J.; Dupere-Richer, D.; Bennett, R. L.; Pondugula, S.; Riva, A.; Cogle, C. R.; Opavsky, R.; Law, B. K.; Kubicek, S.; Staber, P. B.; Licht, J. D.; Bird, J. E.; Guryanova, O. A.
10.1101/2021.05.28.445639 — cancer biology — Posted on 2021-05-28
350 Novel antibodies for the simple and efficient enrichment of native O-GlcNAc modified peptides
Burt, R. A.; Dejanovic, B.; Peckham, H. J.; Lee, K. A.; Li, X.; Ounadjela, J. R.; Rao, A.; Malaker, S. A.; Carr, S. A.; Myers, S. A.
10.1101/2021.05.28.446228 — biochemistry — Posted on 2021-05-28
355 Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion
Lohia, R.; Le Guet, J.; Berry, L.; Guizouarn, H.; Bernal, R.; Cerdan, R.; Abkarian, M.; Douguet, D.; Honore, E.; Wengelnik, K.
10.1101/2021.05.28.446171 — microbiology — Posted on 2021-05-28
356 Differential transcriptomic response of Anopheles arabiensis to Plasmodium vivax and Plasmodium falciparum infection
Tchioffo Tsapi, M.; Kornobis, E.; Puchot, N.; English, S.; Proux, C.; Goupeyou-Youmsi, J.; Sakuntabhai, A.; Dillies, M.-A.; Randrianarivelojosia, M.; Girod, R.; Ndiath, M. o.; Bourgouin, C.
10.1101/2021.05.28.446219 — microbiology — Posted on 2021-05-28
357 Diverse Genetic Determinants of Nitrofurantoin Resistance in UK Escherichia coli
Wan, Y.; Mills, E.; Leung, R. C. Y.; Vieira, A.; Jauneikaite, E.; Zhi, X.; Croucher, N. J.; Woodford, N.; Ellington, M. J.; Sriskandan, S.
10.1101/2021.05.27.446087 — microbiology — Posted on 2021-05-28
358 Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus
Downey, J.; Randolph, H. E.; Pernet, E.; Tran, K. A.; Khader, S. A.; King, I. L.; Barriero, L. B.; Divangahi, M.
10.1101/2021.05.28.445832 — immunology — Posted on 2021-05-28
359 Multi-omics analysis of xylem sap uncovers dynamic modulation of poplar defenses by ammonium and nitrate
Kasper, K. H.; Abreu, I. N.; Feussner, K.; Zienkiewicz, K.; Herrfurth, C.; Ischebeck, T.; Janz, D.; Majcherczyk, A.; Schmitt, K.; Valerius, O.; Braus, G. H.; Feussner, I.; Polle, A.
10.1101/2021.05.28.446139 — plant biology — Posted on 2021-05-28
362 Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation of long non-coding RNAs
Lelong, E. I. J.; Adjibade, P.; Joncas, F.-H.; Khelifi, G.; Grenier St-Sauveur, V.; Zoubeidi, A.; Lambert, J.-P.; Toren, P.; Mazroui, R.; Hussein, S. M. I.
10.1101/2021.01.05.425492 — cancer biology — Posted on 2021-05-28
366 Deconvolving clinically relevant cellular immune crosstalk from bulk gene expression using CODEFACS and LIRICS
Wang, K.; Patkar, S.; Lee, J. S.; Gertz, E. M.; Robinson, W.; Schischlik, F.; Crawford, D.; Schaffer, A. A.; Ruppin, E.
10.1101/2021.01.20.427515 — bioinformatics — Posted on 2021-05-28
367 Multiview super-resolution microscopy
Wu, Y.; Han, X.; Su, Y.; Glidewell, M.; Daniels, J. S.; Liu, J.; Sengupta, T.; Rey-Suarez, I.; Fischer, R.; Patel, A.; Combs, C.; Sun, J.; Wu, X.; Christensen, R.; Smith, C.; Bao, L.; Sun, Y.; Duncan, L. H.; Chen, J.; Pommier, Y.; Shi, Y.-B.; Murphy, E.; Roy, S.; Upadhyaya, A.; Colon-Ramos, D.; La Riviere, P.; Shroff, H.
10.1101/2021.05.21.445200 — bioengineering — Posted on 2021-05-28
368 Modular biosynthesis of plant hemicellulose and its impact on yeast cells
Robert, M.; Waldhauer, J.; Stritt, F.; Yang, B.; Pauly, M.; Voiniciuc, C.
10.1101/2021.04.20.440611 — bioengineering — Posted on 2021-05-28
371 Chimeric RNA:DNA Donorguide Improves HDR in vitro and in vivo
Simone, B. W.; Lee, H. B.; Daby, C. L.; Restrepo-Castillo, S.; Ata, H.; Martinez-Galvez, G.; Gendron, W. A.; Clark, K.; Ekker, S. C.
10.1101/2021.05.28.446234 — genetics — Posted on 2021-05-28
375 The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin
Peacock, T. P.; Sheppard, C. M.; Brown, J. C.; Goonawardane, N.; Zhou, J.; Whiteley, M.; PHE Virology Consortium, ; de Silva, T. I.; Barclay, W. S.
10.1101/2021.05.28.446163 — microbiology — Posted on 2021-05-28
376 Digital PCR to quantify ChAdOx1 nCoV-19 copies in blood and tissues
Badbaran, A.; Mailer, R.; Dahlke, C.; Woens, J.; Fathi, A.; Mellinghoff, S. C.; Renne, T.; Addo, M. M.; Riecken, K.; Fehse, B.
10.1101/2021.05.28.446155 — microbiology — Posted on 2021-05-28
379 Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression
Masuda, I.; Hwang, J.-Y.; Christian, T.; Maharjan, S.; Mohammad, F.; Gamper, H.; Buskirk, A.; Hou, Y.-M.
10.1101/2021.05.27.446073 — microbiology — Posted on 2021-05-28
380 Nfkbid is required for immunity and antibody responses to Toxoplasma gondii
Souza, S. P.; Splitt, S. D.; Alvarez, J. A.; Sanchez-Arcila, J. C.; Wilson, J.; Wizzard, S.; Luo, Z.; Baumgarth, N.; Jensen, K.
10.1101/2020.06.26.174151 — immunology — Posted on 2021-05-28
382 Dynamical processing of orientation precision in the primary visual cortex
Ladret, H. J.; Cortes, N.; Ikan, L.; Chavane, F.; Casanova, C.; Perrinet, L. U.
10.1101/2021.03.30.437692 — neuroscience — Posted on 2021-05-28
385 Biophysical characterization of the SARS-CoV-2 E protein
Mehregan, A.; Perez-Conesa, S.; Zhuang, Y.; Elbahnsi, A.; Pasini, D.; Lindahl, E.; Howard, R. J.; Ulens, C.; Delemotte, L.
10.1101/2021.05.28.446179 — biophysics — Posted on 2021-05-28
387 SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia
Beucher, G.; Blondot, M.-L.; Celle, A.; Pied, N.; Recordon-Pinson, P.; Esteves, P.; Faure, M.; Metifiot, M.; Lacomme, S.; Dacheaux, D.; Robinson, D. R.; Laengst, G.; Beaufils, F.; Lafon, M.-E.; Berger, P.; Landry, M.; Malvy, J.-M. D.; Trian, T.; Andreola, M.-L.; Wodrich, H.
10.1101/2021.05.28.446159 — microbiology — Posted on 2021-05-28
391 Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.
Neary, M.; Arshad, U.; Tatham, L.; Pertinez, H.; Box, H.; Rajoli, R. K.; Valentijn, A.; Sharp, J.; Rannard, S. P.; Biagini, G. A.; Curley, P.; Owen, A.
10.1101/2021.05.27.445500 — pharmacology and toxicology — Posted on 2021-05-28
393 Cellular-resolution monitoring of ischemic stroke pathologies in the rat cortex
Chornyy, S.; Das, A.; Borovicka, J. A.; Patel, D.; Chan, H. H.; Hermann, J. K.; Jaramillo, T. C.; Machado, A. G.; Baker, K. B.; Dana, H.
10.1101/2021.05.27.446026 — neuroscience — Posted on 2021-05-28
398 Sustained ability of a natural microbial community to remove nitrate from groundwater
Paradis, C. J.; Miller, J. I.; Moon, J.-W.; Spencer, S. J.; Lui, L. M.; Van Nostrand, J. D.; Ning, D.; Steen, A. D.; McKay, L. D.; Arkin, A. P.; Zhou, J.; Alm, E. J.; Hazen, T. C.
10.1101/2021.05.27.446013 — ecology — Posted on 2021-05-28
399 Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome
Srivastava, S.; Verhagen, A.; Sasmal, A.; Wasik, B. R.; Diaz, S.; Yu, H.; Bensing, B. A.; Khan, N.; Khedri, Z.; Secrest, P.; Sullam, P.; Varki, N.; Chen, X.; Parrish, C. R.; Varki, A.
10.1101/2021.05.28.446202 — molecular biology — Posted on 2021-05-28
400 Rapid evolution of bacterial AB5 toxin B subunits independent of A subunits: sialic acid binding preferences correlate with host range and toxicity
Khan, N.; Sasmal, A.; Khedri, Z.; Secrest, P.; Verhagen, A.; Srivastava, S.; Varki, N.; Chen, X.; Yu, H.; Beddoe, T.; Paton, A. W.; Paton, J. C.; Varki, A.
10.1101/2021.05.28.446168 — molecular biology — Posted on 2021-05-28
403 Structure-based Classification of Tauopathies
Shi, Y.; Zhang, W.; Yang, Y.; Murzin, A. G.; Falcon, B.; Kotecha, A.; van Beers, M.; Tarutani, A.; Kametani, F.; Garringer, H. J.; Vidal, R.; Hallinan, G. I.; Lashley, T.; Saito, Y.; Murayama, S.; Yoshida, M.; Tanaka, H.; Kakita, A.; Ikeuchi, T.; Robinson, A. C.; Mann, D. M. A.; Kovacs, G. G.; Revesz, T.; Ghetti, B.; Hasegawa, M.; Goedert, M.; Scheres, S.
10.1101/2021.05.28.446130 — neuroscience — Posted on 2021-05-28
406 Late-in-life treadmill-training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.
Cho, J. M.; Ly, K.; Ramous, C.; Thompson, L.; Hansen, M.; Mattera, M. S. d. L. C.; Pires, K. M.; Ferhat, M.; Whitehead, K. J.; Carter, K.; Buffolo, M.; Ghosh, R.; Park, S.-K.; Boudina, S.; Symons, J. D.
10.1101/2021.05.27.446031 — physiology — Posted on 2021-05-28
407 Activating P2Y1 receptors improves function in arteries with repressed autophagy
Cho, J. M.; Park, S.-K.; Kwon, O. S.; La Salle, D. T.; Cerbie, J.; Fermoyle, C. C.; Morgan, D.; Nelson, A.; Bledsoe, A.; Bharath, L. P.; Tandar, M.; Kunapuli, S. P.; Richardson, R. S.; Pon Velayutham, A. B.; Mookherjee, S.; Kishore, B. K.; Wang, F.; Yang, T.; Boudina, S.; Trinity, J. D.; Symons, J. D.
10.1101/2021.05.27.445652 — physiology — Posted on 2021-05-28
408 Multi-dimensional analyses identify genes of high priority for pancreatic cancer research
Nwosu, Z. C.; Giza, H.; Nassif, M.; Charlestin, V.; Menjivar, R. E.; Kim, D.; Kemp, S.; Steele, N.; Hu, J.; Hu, B.; Wang, S.; Pasca di Magliano, M.; Lyssiotis, C. A.
10.1101/2021.05.28.446056 — cancer biology — Posted on 2021-05-28
409 Robust Segmentation of Cellular Ultrastructure on Sparsely Labeled 3D Electron Microscopy Images using Deep Learning
Machireddy, A.; Thibault, G.; Loftis, K. G.; Stoltz, K.; Bueno, C. E.; Smith, H. R.; Riesterer, J. L.; Gray, J. W.; Song, X.
10.1101/2021.05.27.446019 — cancer biology — Posted on 2021-05-28
410 An Efficient Method to Quantify Structural Distributions in Heterogeneous cryo-EM Datasets
Gu, H.; Wang, W.; UNARTA, I. C.; Zeng, W.; Sheong, F. K.; Cheung, P.; Liu, S.; Yao, Y.; Huang, X.
10.1101/2021.05.27.446075 — biophysics — Posted on 2021-05-28
415 Noise Reconstruction & Removal Network: A New Architecture to Denoise FIB-SEM Images
Giannios, K.; Chaurasia, A.; Thibault, G.; Riesterer, J. L.; Stempinski, E.; Lo, T.; DeLaRosa, B.; Gray, J. W.
10.1101/2021.05.27.446051 — bioengineering — Posted on 2021-05-28
416 Pro-regenerative Extracellular Matrix Hydrogel Prevents and Mitigates Pathological Alterations of Pelvic Muscles Following Birth Injury
Duran, P.; Sesillo, F. B.; Burnett, L.; Menefee, S. A.; Cook, M.; Zazueta-Damian, G.; Dzieciatkowska, M.; Do, E.; French, S.; Shah, M. M.; Sanvictores, C.; Hansen, K.; Shtrahman, M.; Christman, K. L.; Alperin, M.
10.1101/2021.05.28.446170 — bioengineering — Posted on 2021-05-28
422 Individual expression of hepatitis A virus 3C protease induces ferroptosis in human cells in vitro
Komissarov, A. A.; Karaseva, M. A.; Roschina, M. P.; Shubin, A. V.; Lunina, N. A.; Kostrov, S. V.; Demidyuk, I. V.
10.1101/2021.05.28.446108 — cell biology — Posted on 2021-05-28
424 A comprehensive mass spectral library for human thyroid tissues
Sun, Y.; Li, L.; Ge, W.; Dong, Z.; Liu, W.; Chen, H.; Xiao, Q.; Cai, X.; Zhang, F.; Xiao, J.; Wang, G.; He, Y.; Kon, O. L.; Iyer, N. G.; Zhao, Y.; Guo, T.
10.1101/2021.05.27.445992 — systems biology — Posted on 2021-05-28
425 The skeletal muscle circadian clock regulates sarcomere length homeostasis through titin splicing
Riley, L.; Zhang, X.; Mijares, J.; Hammers, D.; Olafson, H.; Du, P.; Douglas, C.; Labeit, S.; T. Wang, E.; Esser, K. A.
10.1101/2021.05.27.445953 — physiology — Posted on 2021-05-28
426 Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest
Adams, A. C.; Macy, A. M.; Kang, P.; Castro-Ochoa, K. F.; Wijeratne, E. M. K.; Xu, Y.-M.; Liu, M. X.; Charos, A.; Bosenberg, M. W.; Gunatilaka, A. A. L.; Sertil, A. R.; Hastings, K. T.
10.1101/2021.05.27.445710 — cancer biology — Posted on 2021-05-28
427 Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus
Herms, A.; Colom, B.; Piedrafita, G.; Murai, K.; Ong, S. H.; Fernandez-Antoran, D.; Bryant, C.; Frezza, C.; Vanhaesebroeck, B.; Jones, P. H.
10.1101/2021.05.28.446104 — cancer biology — Posted on 2021-05-28
428 Spontaneous polarization and cell guidance on asymmetric nanotopography
Herr, C.; Winkler, B.; Ziebert, F.; Aranson, I. S.; Fourkas, J. T.; Losert, W.
10.1101/2021.05.27.445842 — biophysics — Posted on 2021-05-28
431 Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
Robertson, N. A.; Latorre-Crespo, E.; Terrada-Terradas, M.; Purcell, A. C.; Livesey, B. J.; Marsh, J. A.; Murphy, L.; Fawkes, A.; MacGillvray, L.; Copland, M.; Marioni, R. E.; Harris, S. E.; Cox, S. R.; Deary, I. J.; Schumacher, L. J.; Kirschner, K.; Chandra, T.
10.1101/2021.05.27.446006 — cell biology — Posted on 2021-05-28
432 A deep-learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders
Aljovic, A.; Zhao, S.; Chahin, M.; de la Rosa del Val, C.; Van Steenbergen, V.; Kerschensteiner, M.; Bareyre, F. M.
10.1101/2021.05.27.445999 — neuroscience — Posted on 2021-05-28
433 Estradiol Influences Adenosinergic Signaling and NREM Sleep Need in Adult Female Rats
Smith, P. C.; Phillips, D. J.; Pocivavsek, A.; Byrd, C. A.; Viechweg, S. S.; Hampton, B.; Mong, J. A.
10.1101/2021.05.27.445868 — neuroscience — Posted on 2021-05-28
434 Elevated colonic microbiota-associated paucimannosidic and truncated N-glycans in pediatric ulcerative colitis
Li, H.; Zhang, X.; Chen, R.; Cheng, K.; Ning, Z.; Li, J.; Twine, S.; Stintzi, A.; Mack, D.; Figeys, D.
10.1101/2021.05.27.446002 — systems biology — Posted on 2021-05-28
435 ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer
Fang, W.; Liao, C.; Shi, R.; Simon, J.; Ptacek, T.; Zurlo, G.; Ye, Y.; Han, L.; Fan, C.; Ortiz, C. L.; Lin, H.-R.; Manocha, U.; Luo, W.; Kim, W. Y.; Yang, L.-W.; Zhang, Q.
10.1101/2021.05.27.445959 — cancer biology — Posted on 2021-05-28
436 Surveillance of in situ tumor arrays reveals early environmental control of cancer immunity
Ortiz-Munoz, G.; Brown, M.; Carbone, C. B.; Pechuan Jorge, J.; Ritter, A.; Orlova, D.; Mantri, S. R.; Yang, A.; Doerr, J.; Mariathasan, S.; Wang, Y.; Turley, S.; Gomez-Roca, C.; Eduardo de Andrea, C.; Spigel, D.; Wu, T. D.; Modrusan, Z.; Price, R.; Mellman, I.; Moussion, C.
10.1101/2021.05.27.445482 — cancer biology — Posted on 2021-05-28
437 FAIRSCAPE: A Framework for FAIR and Reproducible Biomedical Analytics
Levinson, M. A.; Niestroy, J.; Al Manir, S.; Fairchild, K. D.; Lake, D. E.; Moorman, J. R.; Clark, T.
10.1101/2020.08.10.244947 — bioinformatics — Posted on 2021-05-28
438 Identifying and Classifying Goals For Scientific Knowledge
Boguslav, M. R.; Salem, N. M.; White, E. K.; Leach, S. M.; Hunter, L. E.
10.1101/2021.05.27.445866 — bioinformatics — Posted on 2021-05-28
439 Predictive Modeling of Pseudomonas syringae Virulence on Bean using Gradient Boosted Decision Trees
Almeida, R. N. D.; Greenberg, M.; Bundalovic-Torma, C.; Martel, A.; Wang, P. W.; Middleton, M.; Chatterton, S.; Desveaux, D.; Guttman, D. S.
10.1101/2021.05.27.445966 — genomics — Posted on 2021-05-28
441 hei-tag: a highly efficient tag to boost targeted genome editing
Thumberger, T.; Tavhelidse, T.; Gutierrez-Triana, J. A.; Medert, R.; Cornean, A.; Welz, B.; Freichel, M.; Wittbrodt, J.
10.1101/2021.05.27.445956 — genetics — Posted on 2021-05-28
447 Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease
Raval, N. R.; Gudmundsen, F.; Juhl, M.; Petersen, I. N.; Videbaek, A.; Mikkelsen, J. D.; Fisher, P. M.; Plaven-Sigray, P.; Knudsen, G. M.; Palner, M.
10.1101/2021.05.27.444950 — neuroscience — Posted on 2021-05-28
448 Functional connectome reorganization relates to post-stroke motor recovery and structural disconnection
Olafson, E.; Jamison, K.; Sweeney, E.; Liu, H.; Wang, D.; Bruss, J.; Boes, A.; Kuceyeski, A.
10.1101/2021.05.27.445834 — neuroscience — Posted on 2021-05-28
451 IN VIVO ANALYSIS OF THE ROLE OF GASDERMIN-B (GSDMB) IN CANCER USING NOVEL KNOCK-IN MOUSE MODELS
SARRIO, D.; ROJO-SEBASTIAN, A.; TEIJO, A.; PEREZ-LOPEZ, M.; DIAZ-MARTIN, E.; MARTINEZ, L.; MORALES, S.; GARCIA-SANZ, P.; PALACIOS, J.; MORENO-BUENO, G.
10.1101/2021.05.27.445936 — cancer biology — Posted on 2021-05-28
452 Jasmine: Population-scale structural variant comparison and analysis
Kirsche, M.; Prabhu, G.; Sherman, R.; Ni, B.; Aganezov, S.; Schatz, M. C.
10.1101/2021.05.27.445886 — genomics — Posted on 2021-05-28
459 Unbiased screen of human transcriptome reveals an unexpected role of 3'UTRs in translation initiation
Wang, Z.; Yang, Y.; Fan, X.; Ye, Y.; Chen, C.; Ludwig, S. E. J.; Zhang, S.; Lu, Q.; Will, C. L.; Urlaub, H.; Sun, J.; Lu?hrmann, R.
10.1101/2021.05.28.446092 — molecular biology — Posted on 2021-05-28
460 Cooperativity of catalytic and lectin-like domain of T. congolense trans-sialidase modulates its catalytic activity
Waespy, M.; Gbem, T. T.; Dinesh Kumar, N.; Solaiyappan Mani, S.; Rosenau, J.; Dietz, F.; Kelm, S.
10.1101/2021.05.28.446113 — biochemistry — Posted on 2021-05-28
461 Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elements
Ibarra, I. L.; Ratnu, V. S.; Gordillo, L.; Hwang, I.-Y.; Mariani, L.; Weinand, K.; Hammaren, H. M.; Bulyk, M. L.; Savitski, M. M.; Zaugg, J. B.; Noh, K.-M.
10.1101/2021.05.28.446128 — genomics — Posted on 2021-05-28
462 Modulation of the host cell transcriptome and epigenome by Fusobacterium nucleatum
Despins, C. A.; Brown, S. D.; Robinson, A. V.; Mungall, A. J.; Allen-Vercoe, E.; Holt, R. A.
10.1101/2021.05.28.445195 — genomics — Posted on 2021-05-28
464 Density-based binning of gene clusters to infer function or evolutionary history using GeneGrouper
McFarland, A. G.; Kennedy, N. W.; Mills, C. E.; Tullman-Ercek, D.; Huttenhower, C.; Hartmann, E. M.
10.1101/2021.05.27.446007 — bioinformatics — Posted on 2021-05-28
465 Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics
Dindo, M.; Pascarelli, S.; Chiasserini, D.; Grottelli, S.; Costantini, C.; Uechi, G.-I.; Giardina, G.; Laurino, P.; Cellini, B.
10.1101/2021.05.24.445519 — biochemistry — Posted on 2021-05-28
469 Reprogrammed tracrRNAs enable repurposing RNAs as crRNAs and detecting RNAs
Liu, Y.; Pinto, F.; Wan, X.; Peng, S.; Li, M.; Xie, Z.; French, C. E.; Wang, B.
10.1101/2021.05.24.445356 — synthetic biology — Posted on 2021-05-28
470 The temperature-regulated DEAD-box RNA helicase CrhR interactome: Autoregulation and photosynthesis-related transcripts
Migur, A.; Heyl, F.; Fuss, J.; Srikumar, A.; Huettel, B.; Steglich, C.; Prakash, J. S. S.; Reinhardt, R.; Backofen, R.; Owttrim, G. W.; Hess, W. R.
10.1101/2021.03.26.437152 — plant biology — Posted on 2021-05-28
474 PTEN regulates adipocyte progenitor growth, differentiation and replicative aging
Kirstein, A. S.; Kehr, S.; Nebe, M.; Hanschkow, M.; Lorenz, J.; Penke, M.; Breitfeld, J.; Le Duc, D.; Landgraf, K.; Koerner, A.; Kovacs, P.; Stadler, P. F.; Kiess, W.; Garten, A.
10.1101/2021.01.05.425433 — cell biology — Posted on 2021-05-28
475 Eye movements during text reading align with the rate of speech production
Gagl, B.; Gregorova, K.; Golch, J.; Hawelka, S.; Sassenhagen, J.; Tavano, A.; Poeppel, D.; Fiebach, C. J.
10.1101/391896 — neuroscience — Posted on 2021-05-28
477 Upregulated-flotillins and sphingosine kinase 2 derail vesicular trafic to stabilize AXL and promote epithelial-mesenchymal transition
Genest, M.; Comunale, F.; Planchon, D.; Govindin, P.; Vacher, S.; Bieche, I.; Robert, B.; Malhotra, H.; Schoenit, A.; Tashireva, L.; Gauthier-Rouviere, C.; Bodin, S.
10.1101/2020.05.12.090571 — cell biology — Posted on 2021-05-28
479 The LOTUS Initiative for Open Natural Products Research: Knowledge Management through Wikidata
Rutz, A.; Sorokina, M.; Galgonek, J.; Mietchen, D.; Willighagen, E.; Gaudry, A.; Graham, J. G.; Stephan, R.; Page, R.; Vondrasek, J.; Steinbeck, C.; Pauli, G.; Wolfender, J.-L.; Bisson, J.; Allard, P.-M.
10.1101/2021.02.28.433265 — bioinformatics — Posted on 2021-05-28
480 The geometry of decision-making
Sridhar, V. H.; Li, L.; Gorbonos, D.; Nagy, M.; Schell, B. R.; Sorochkin, T.; Gov, N. S.; Couzin, I. D.
10.1101/2021.05.26.445795 — animal behavior and cognition — Posted on 2021-05-28
482 Hackflex: low cost Illumina Nextera Flex sequencing library construction
Gaio, D.; Anantanawat, K.; To, J.; Liu, M.; Monahan, L.; Darling, A. E.
10.1101/779215 — genomics — Posted on 2021-05-28
483 Rapid genotyping of tilapia lake virus (TiLV) using Nanopore sequencing
Delamare-Deboutteville, J.; Taengphu, S.; Gan, H. M.; Kayansamruaj, P.; Pratim Debnath, P.; Barnes, A. C.; Wilkinson, S.; Kawasaki, M.; Vishnumurthy, M. C.; Saengchan, S.; Dong, H. T.
10.1101/2021.03.29.437503 — molecular biology — Posted on 2021-05-28
485 Additive Effects of Cognitive Load, Motor Demand, and Environmental Complexity on Attention: A Real-World EEG-study
Liebherr, M.; Corcoran, A. W.; Alday, P. M.; Coussens, S.; Bellan, V.; Howlett, C. A.; Immink, M. A.; Kohler, M.; Schlesewsky, M.; Bornkessel-Schlesewsky, I.
10.1101/2021.05.27.445993 — neuroscience — Posted on 2021-05-27
490 Estrogen Drives Melanocortin Neurons To Increase Spontaneous Activity and Reduce Sedentary Behavior
Krause, W. C.; Rodriguez, R.; Gegenhuber, J. B.; Matharu, N.; Rodriguez, A. N.; Padilla-Roger, A.; Toma, K.; Herber, C. B.; Correa, S. M.; Duan, X.; Ahituv, N. M.; Tollkuhn, J.; Ingraham, H. A.
10.1101/794792 — neuroscience — Posted on 2021-05-27
495 Counterfactual Hypothesis Testing of Tumor Microenvironment Scenarios Through Semantic Image Synthesis
Li, D.; Chen, J. L.; Ma, Q.; Xie, Y.; Liu, A.; Cheung, J.; Gudjonson, H.; Nawy, T.; Pe'er, D.; Pe'er, I.
10.1101/2020.10.27.358101 — cancer biology — Posted on 2021-05-27
496 Axes of inter-sample variability among transcriptional neighborhoods reveal disease associated cell states in single-cell data
Reshef, Y. A.; Rumker, L.; Kang, J. B.; Nathan, A.; Korsunsky, I.; Asgari, S.; Murray, M. B.; Moody, D. B.; Raychaudhuri, S.
10.1101/2021.04.19.440534 — bioinformatics — Posted on 2021-05-27
500 Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
Ji, D. X.; Witt, K. C.; Kotov, D. I.; Margolis, S. R.; Louie, A.; Chevee, V.; Chen, K. J.; Gaidt, M.; Dhaliwal, H. S.; Lee, A. Y.; Nishimura, S.; Zamboni, D. S.; Kramnik, I.; Portnoy, D. A.; Darwin, K. H.; Vance, R. E.
10.1101/2020.01.07.897553 — immunology — Posted on 2021-05-27
501 Successful IL-12 cancer immunotherapy requires NK cell-derived CCL5 for anti-tumor DC-T cell crosstalk
Kirchhammer, N.; Trefny, M. P.; Natoli, M.; Bruecher, D.; Smith, S. N.; Werner, F.; Koch, V.; Schreiner, D.; Bartoszek, E.; Buchi, M.; Schmid, M.; Breu, D.; Hartmann, K. P.; Zaytseva, P.; Thommen, D. S.; Laubli, H.; Stanczak, M. A.; Kashyap, A.; Plueckthun, A.; Zippelius, A.
10.1101/2021.05.27.445981 — immunology — Posted on 2021-05-27
502 An interpretable connectivity-based decoding model for classification of chronic marijuana use
Kulkarni, K. R.; Schafer, M.; Berner, L.; Fiore, V. G.; Heflin, M.; Hutchison, K.; Calhoun, V.; Filbey, F.; Pandey, G.; Schiller, D.; Gu, X.
10.1101/2021.05.04.442433 — neuroscience — Posted on 2021-05-27
503 Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
Fernandez-Leon, J. A.; Engelke, D. S.; Aquino-Miranda, G.; Goodson, A.; Do Monte, F. H.
10.1101/2021.05.27.445881 — neuroscience — Posted on 2021-05-27
504 Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria
Balakrishnan, R.; Mori, M.; Segota, I.; Zhang, Z.; Aebersold, R.; Ludwig, C.; Hwa, T.
10.1101/2021.05.24.445329 — systems biology — Posted on 2021-05-27
507 Predicting phenotypes from genetic, environment, management, and historical data using CNNs
Washburn, J. D.; Cimen, E.; Ramstein, G.; Reeves, T.; O'Briant, P.; McLean, G.; Cooper, M.; Hammer, G.; Buckler, E. S.
10.1101/2021.05.27.446033 — plant biology — Posted on 2021-05-27
508 Personalized chordoma organoids for drug discovery studies
Al Shihabi, A.; Davarifar, A.; Nguyen, H. T. L.; Tavanaie, N.; Nelson, S. D.; Yanagawa, J.; Federman, N.; Bernthal, N.; Hornicek, F.; Soragni, A.
10.1101/2021.05.27.446040 — cancer biology — Posted on 2021-05-27
510 The stiffness-sensitive transcriptome of human tendon stromal cells
Hussien, A. A.; Niederoest, B.; Bollhalder, M.; Goedecke, N.; Snedeker, J. G.
10.1101/2021.05.27.445865 — bioengineering — Posted on 2021-05-27
513 TnCentral: A Prokaryotic Transposable Element Database and Web Portal for Transposon Analysis
Ross, K.; Varani, A. M.; Snesrud, E.; Huang, H.; Alvarenga, D. O.; Zhang, J.; Wu, C.; McGann, P.; Chandler, M. G.
10.1101/2021.05.26.445724 — genomics — Posted on 2021-05-27
514 de novo variant calling identifies cancer mutation profiles in the 1000 Genomes Project
Ng, J. K.; Vats, P.; Fritz-Waters, E.; Padhi, E. M.; Payne, Z. L.; Leonard, S.; Sarkar, S.; West, M.; Prince, C.; Trani, L.; Jansen, M.; Vacek, G.; Samadi, M.; Harkins, T. T.; Pohl, C.; Turner, T. N.
10.1101/2021.05.27.445979 — genomics — Posted on 2021-05-27
515 Machine learning approaches to identify sleep genes
Lee, Y. Y.; Endale, M.; Wu, G.; Ruben, M. D.; Francey, L. J.; Morris, A. R.; Choo, N. Y.; Anafi, R. C.; Smith, D. F.; Liu, A. C.; Hogenesch, J. B.
10.1101/2021.04.10.439249 — genomics — Posted on 2021-05-27
516 Inferring Mycobacterium bovis transmission between cattle and badgers using isolates from the Randomised Badger Culling Trial
van Tonder, A. J.; Thornton, M.; Conlan, A. J.; Jolley, K. A.; Goolding, L.; Mitchell, A. P.; Dale, J.; Palkopoulou, E.; Hogarth, P. J.; Hewinson, R. G.; Wood, J. L.; Parkhill, J.
10.1101/2021.05.27.445931 — genomics — Posted on 2021-05-27
517 The role of behavioural flexibility in primate diversification
Creighton, M. J. A.; Greenberg, D. A.; Reader, S. M.; Mooers, A. O.
10.1101/2020.10.15.341859 — evolutionary biology — Posted on 2021-05-27
518 Unleashing a Novel Function of Endonuclease G in Mitochondrial Genome Instability
Dahal, S.; Siddiqua, H.; Sharma, S.; Babu, R. K.; Manjunath, M.; Sharma, S.; Choudhary, B.; Raghavan, S.
10.1101/2021.05.27.445952 — molecular biology — Posted on 2021-05-27
520 Deciphering microbiome impacts on fungal-microalgal interaction in a marine environment using metabolomics
Berry, O.; Briand, E.; Bagot, A.; Chaigne, M.; Meslet-Cladiere, L.; Wang, J.; Grovel, O.; Jansen, J. J.; Ruiz, N.; Robiou du Pont, T.; Pouchus, Y. F.; Hess, P.; Bertrand, S.
10.1101/2021.05.27.445989 — microbiology — Posted on 2021-05-27
521 Electrolysis of Bacterial Biofilm
Azimi, A.; Bazargani, A.; Farhadi, P.; Naghibi Irvani, S. S.; Moatari, P.
10.1101/2021.05.27.445919 — microbiology — Posted on 2021-05-27
524 Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei
Carbajo, C. G.; Cornell, L. J.; Madbouly, Y.; Lai, Z.; Yates, P. A.; Tinti, M.; Tiengwe, C.
10.1101/2021.05.27.445749 — microbiology — Posted on 2021-05-27
527 The AP-1 factors FOSL1 and FOSL2 co-regulate human Th17 responses
Shetty, A.; Tripathi, S. K.; Junttila, S.; Buchacher, T.; Biradar, R.; Bhosale, S. D.; Envall, T.; Laiho, A.; Moulder, R.; Rasool, O.; Galande, S.; Elo, L. L.; Lahesmaa, R.
10.1101/2021.04.26.441472 — immunology — Posted on 2021-05-27
529 Cell type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons
Forget, B.; Martin Garcia, E.; Godino, A.; Domingo Rodriguez, L.; Kappes, V.; Poirier, P.; Andrianarivelo, A.; Senabre Marchan, E.; Allichon, M. C.; Marias, M.; Vanhoutte, P.; Girault, J.-A.; Maldonado, R.; Caboche, J.
10.1101/2021.05.27.445939 — neuroscience — Posted on 2021-05-27
530 Skeletal maturity predicts cognitive abilitiesin human adolescents
Kovacs, I.; Kovacs, K.; Gervan, P.; Utczas, K.; Olah, G.; Troznai, Z.; Berencsi, A.; Szakacs, H.; Gombos, F.
10.1101/2021.05.02.442351 — neuroscience — Posted on 2021-05-27
531 The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice
Wearing, O. H.; Ivy, C. M.; Guttierrez-Pinto, N.; Velotta, J. P.; Campbell-Staton, S. C.; Natarajan, C.; Cheviron, Z. A.; Storz, J. F.; Scott, G. R.
10.1101/2020.10.29.357665 — physiology — Posted on 2021-05-27
532 Effect of Suppression of Rotational Joint Instability on Cartilage and Meniscus Degeneration in Mouse Osteoarthritis Model
Arakawa, K.; Takahata, K.; Oka, Y.; Ozone, K.; Morosawa, K.; Enomoto, S.; Murata, K.; Kanemura, N.; Kokubun, T.
10.1101/2021.05.27.445937 — pathology — Posted on 2021-05-27
533 Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA
Bergstrom, E. N.; Luebeck, J.-C.; Petljak, M.; Bafna, V.; Mischel, P. S.; Harris, R.; Alexandrov, L. B.
10.1101/2021.05.27.445689 — cancer biology — Posted on 2021-05-27
536 DeepNull: Modeling non-linear covariate effects improves phenotype prediction and association power
Hormozdiari, F.; Mccaw, Z. R.; Colthurst, T.; Yun, T.; Furlotte, N.; Carroll, A.; Alipanahi, B.; McLean, C.
10.1101/2021.05.26.445783 — genetics — Posted on 2021-05-27
537 AURKB/Ipl1 restarts replication forks to recover from replication stress.
Moran, E.; Pfister, K. E.; Sathyan, K. M.; Vignero, B.; Burke, D. J.; Stukenberg, T.
10.1101/2021.05.27.446025 — cell biology — Posted on 2021-05-27
538 Dimerization of SARS-CoV-2 nucleocapsid protein affects sensitivity of ELISA based diagnostics of COVID-19
Khan, W. H.; Khan, N.; Mishra, A.; Gupta, S.; Bansode, V.; Mehta, D.; Bhambure, R.; Rathore, A. S.
10.1101/2021.05.23.445305 — molecular biology — Posted on 2021-05-27
539 Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages
Meeske, A. J.; Johnson, M. C.; Hille, L. T.; Kleinstiver, B. P.; Bondy-Denomy, J.
10.1101/2021.05.27.445852 — molecular biology — Posted on 2021-05-27
540 Human HELB is a processive motor protein which catalyses RPA clearance from single-stranded DNA
Hormeno, S.; Wilkinson, O. J.; Aicart-Ramos, C.; Kuppa, S.; Antony, E.; Dillingham, M. S.; Moreno-Herrero, F.
10.1101/2021.05.27.445972 — molecular biology — Posted on 2021-05-27
541 Genetic tools for the stable overexpression of circular RNAs
Mecozzi, N.; Nenci, A.; Vera, O.; Falzone, A.; DeNicola, G. M.; Karreth, F. A.
10.1101/2021.05.27.446018 — molecular biology — Posted on 2021-05-27
547 Dynamics of repair and regeneration of adult zebrafish respiratory gill tissue after cryoinjury.
Ramel, M.-C.; Progatzky, F.; Rydlova, A.; Wane, M.; Schymeinsky, J.; Williams, C.; Jung, B.; Lamb, J.; Thomas, M. J.; Bugeon, L.; Dallman, M. J.
10.1101/2021.05.27.445469 — immunology — Posted on 2021-05-27
549 Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer Metastasis
Kiweler, N.; Delbrouck, C.; Neises, L.; Pozdeev, V. I.; Soriano-Baguet, L.; Xian, F.; Benzarti, M.; Haase, L.; Schmoetten, M.; Jaeger, C.; Noman, M. Z.; Vazquez, A.; Janji, B.; Dittmar, G.; Brenner, D.; Letellier, E.; Meiser, J.
10.1101/2021.05.27.445928 — cancer biology — Posted on 2021-05-27
551 Feasibility of an Inhalable Ultrasound Contrast Agent to Enhance Airway Imaging
Clapp, P. W.; Durham, P. G.; Antinori, J. C.; Walmer, R. W.; Chlebowski, J. G.; Velasco, B.; Snow, S. J.; Dayton, P. A.; Caughey, M. C.
10.1101/2021.05.27.446053 — bioengineering — Posted on 2021-05-27
552 Portable real-time colorimetric LAMP-device for rapidquantitative detection of nucleic acids in crude samples
Papadakis, G.; Pantazis, A. K.; Fikas, N.; Chatziioannidou, S.; Tsiakalou, V.; Michaelidou, K.; Pogka, V.; Megariti, M.; Vardaki, M.; Giarentis, K.; Heaney, J.; Nastouli, E.; Karamitros, T.; Mentis, A.; Zafiropoulos, A.; Sourvinos, G.; Agelaki, S.; Gizeli, E.
10.1101/2020.07.22.215251 — bioengineering — Posted on 2021-05-27
554 Exploring the natural origins of SARS-CoV-2 in the light of recombination
Lytras, S.; Hughes, J.; Martin, D.; de Klerk, A.; Lourens, R.; Kosakovsky Pond, S. L.; Xia, W.; Jiang, X.; Robertson, D. L.
10.1101/2021.01.22.427830 — evolutionary biology — Posted on 2021-05-27
559 Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy
Mirsanaye, K.; Uribe Castano, L.; Kamaliddin, Y.; Golaraei, A.; Augulis, R.; Kontenis, L.; Done, S. J.; Zurauskas, E.; Wilson, B. C.; Barzda, V.
10.1101/2021.05.26.445874 — pathology — Posted on 2021-05-27
560 Somatic reversion impacts MDS/AML evolution in the short telomere syndromes
Schratz, K. E.; Gayasinskaya, V.; Cosner, Z. L.; DeBoy, E. A.; Xiang, Z.; Kasch-Semenza, L.; Florea, L. D.; Shah, P. D.; Armanios, M.
10.1101/2021.05.26.445858 — cancer biology — Posted on 2021-05-27
561 Rapid propagation of membrane tension at a presynaptic terminal
Gomis Perez, C.; Dudzinski, N. R.; Rouches, M.; Machta, B.; Zenisek, D.; Karatekin, E.
10.1101/2021.05.26.445801 — biophysics — Posted on 2021-05-27
563 Mechanical Forces during Lymph Node Expansion Govern Fibroblastic Reticular Network Remodeling
Horsnell, H. L.; Tetley, R. J.; de Belly, H.; Makris, S.; Benjamin, A. C.; Paluch, E.; Mao, Y.; Acton, S. E.
10.1101/2021.05.27.446027 — biophysics — Posted on 2021-05-27
565 Coral: a web-based visual analysis tool for creating and characterizing cohorts
Adelberger, P.; Eckelt, K.; Bauer, M. J.; Streit, M.; Haslinger, C.; Zichner, T.
10.1101/2021.05.26.445802 — bioinformatics — Posted on 2021-05-27
568 Rational inattention in mice
Grujic, N.; Brus, J.; Burdakov, D.; Polania, R.
10.1101/2021.05.26.445807 — neuroscience — Posted on 2021-05-27
570 Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder
Gelegen, C.; Cash, D.; Ilic, K.; Sander, M.; Kim, E.; Simmons, C.; Bernanos, M.; Lamma, J.; Randall, K.; Brown, J.; Kalanj Bognar, S.; Cooke, S.; Chaudhury, K. R.; Ballard, C.; Francis, P.; Rosenzweig, I.
10.1101/2021.05.26.445845 — neuroscience — Posted on 2021-05-27
571 Cingulate-motor circuits update rule representations for sequential choice decisions
Takeuchi, D.; Roy, D.; Muralidhar, S.; Kawai, T.; Lovett, C.; Sullivan, H. A.; Wickersham, I. R.; Tonegawa, S.
10.1101/2021.05.26.445888 — neuroscience — Posted on 2021-05-27
572 Female mice exhibit a more sensitive automated squint response to pain induced by CGRP and amylin
Rea, B. J.; Sowers, L. P.; Davison, A. L.; Fairbanks, A. M.; Wattiez, A.-S.; Poolman, P.; Kardon, R. H.; Russo, A. F.
10.1101/2021.05.26.445893 — neuroscience — Posted on 2021-05-27
577 Microarrayed human bone marrow organoids for modeling blood stem cell dynamics
Giger, S.; Hofer, M.; Miljkovic-Licina, M.; Hoehnel, S.; Brandenberg, N.; Guiet, R.; Ehrbar, M.; Kleiner, E.; Gegenschatz, K.; Matthes, T.; Lutolf, M. P.
10.1101/2021.05.26.445803 — bioengineering — Posted on 2021-05-27
578 The geometry of decision-making
Sridhar, V. H.; Li, L.; Gorbonos, D.; Nagy, M.; Schell, B. R.; Sorochkin, T.; Gov, N. S.; Couzin, I. D.
10.1101/2021.05.26.445795 — animal behavior and cognition — Posted on 2021-05-27
581 Loose ends in cancer genome structure
Behr, J. M.; Yao, X.; Hadi, K.; Tian, H.; Deshpande, A.; Rosiene, J.; de Lange, T.; Imielinski, M.
10.1101/2021.05.26.445837 — genomics — Posted on 2021-05-27
584 Predicting Bird Distributions Under Global Change
MacPherson, M.; Burgio, K. R.; DeSaix, M.; Freeman, B.; Herbert, J.; Herman, R.; Jirinec, V.; Shonfield, J.; Slager, D.; van Rees, C.; Jankowski, J.
10.1101/2021.05.26.445867 — ecology — Posted on 2021-05-27
586 An altered metabolism in leukocytes showing in vitro igG memory from SARS-CoV-2-infected patients
Fanelli, G.; Gevi, F.; Zarletti, G.; Tiberi, M.; De Molfetta, V.; Scapigliati, G.; Timperio, A.
10.1101/2021.05.27.445918 — cell biology — Posted on 2021-05-27
588 The P5-ATPase ATP13A1 modulates MR1-mediated antigen presentation
Kulicke, C. A.; De Zan, E.; Hein, Z.; Gonzalez-Lopez, C.; Ghanwat, S.; Veerapen, N.; Besra, G.; Klenerman, P.; Christianson, J. C.; Springer, S.; Nijman, S.; Cerundolo, V.; Salio, M.
10.1101/2021.05.26.445708 — immunology — Posted on 2021-05-27
589 Plasmodium falciparum and helminth coinfections increase IgE and parasite-specific IgG responses
Santano, R.; Rubio, R.; Grau-Pujol, B.; Escola, V.; Muchisse, O.; Cuamba, I.; Vidal, M.; Cistero, P.; Ruiz-Olalla, G.; Aguilar, R.; Demontis, M.; Jamine, J. C.; Cossa, A.; Sacoor, C.; Cano, J.; Izquierdo, L.; Chitnis, C. E.; Coppel, R. L.; Chauhan, V.; Cavanagh, D.; Dutta, S.; Angov, E.; Gaur, D.; van Lieshout, L.; Zhan, B.; Munoz, J.; Moncunill, G.; Dobano, C.
10.1101/2021.05.26.445753 — immunology — Posted on 2021-05-27
592 Using OPMs to measure neural activity in standing, mobile participants
Seymour, R. A.; Alexander, N.; Mellor, S. J.; O'Neill, G. C.; Tierney, T. M.; Barnes, G. R.; Maguire, E. A.
10.1101/2021.05.26.445793 — neuroscience — Posted on 2021-05-27
597 Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
Hunter, J. E.; Campbell, A. E.; Hannaway, N. L.; Kerridge, S.; Luli, S.; Butterworth, J. A.; Sellier, H.; Mukherjee, R.; Thomas, H. D.; Brownridge, P. J.; Coxhead, J.; Taylor, L.; Leary, P.; Hasoon, M. S. R.; Collins, I.; Garrett, M. D.; Eyers, C. E.; Perkins, N. D.
10.1101/2021.05.26.445425 — cancer biology — Posted on 2021-05-27
598 Learned deconvolution using physics priors for structured light-sheet microscopy
Wijesinghe, P.; Corsetti, S.; Chow, D. J. X.; Sakata, S.; Dunning, K.; Dholakia, K.
10.1101/2021.05.26.445797 — biophysics — Posted on 2021-05-27
599 TIGER: The gene expression regulatory variation landscape of human pancreatic islets
Alonso, L.; Piron, A.; Moran, I.; Guindo-Martinez, M.; Bonas-Guarch, S.; Atla, G.; Miguel-Escalada, I.; Royo, R.; Puiggros, M.; Garcia-Hurtado, X.; Suleiman, M.; Marselli, L.; Esguerra, J. L. S.; Turatsinze, J.-V.; Torres, J. M.; Nylander, V.; Chen, J.; Eliasson, L.; Defrance, M.; Amela, R.; MAGIC, ; Mulder, H.; Gloyn, A. L.; Groop, L.; Marchetti, P.; Eizirik, D. L.; Ferrer, J.; Mercader, J. M.; Cnop, M.; Torrents, D.
10.1101/2021.05.26.445616 — bioinformatics — Posted on 2021-05-27
600 Rigorous estimation of post-translational proteasomal splicing in the immunopeptidome
Cygan, K. J.; Khaledian, E.; Blumenberg, L.; Salzler, R. R.; Shah, D.; Olson, W.; Macdonald, L. E.; Murphy, A. J.; Dhanik, A.
10.1101/2021.05.26.445792 — bioinformatics — Posted on 2021-05-27
601 Population genomics of wall lizards reflects the dynamic history of the Mediterranean Basin
Yang, W.; Feiner, N.; Salvi, D.; Laakkonen, H.; Jablonski, D.; Pinho, C.; Carretero, M. A.; Sacchi, R.; Zuffi, M. A. L.; Scali, S.; Plavos, K.; Pafilis, P.; Poulakakis, N.; Lymberakis, P.; Jandzik, D.; Schulte, U.; Aubret, F.; Badiane, A.; Lanuza, G. P. i. d.; Abalos, J.; While, G. M.; Uller, T.
10.1101/2021.05.26.445763 — evolutionary biology — Posted on 2021-05-27
602 Genetic diversity of the pathogenic banana Fusarium wilt in northern Viet Nam
Thi, L. L.; Mertens, A.; Vu, T. D.; Vu, T. D.; Minh, P. L. A.; Duc, H. N.; de Backer, S.; Swennen, R.; Vandelook, F.; Panis, B.; Amalfi, M.; Decock, C.; Gomes, S.; Merckx, V.; Janssens, S.
10.1101/2021.05.26.445774 — evolutionary biology — Posted on 2021-05-27
603 Genome-wide evolutionary response of European oakssince the Little Ice Age
Saleh, D.; Chen, J.; Leple, J.-C.; Leroy, T.; Truffaut, L.; Dencausse, B.; Lalanne, C.; Labadie, K.; Lesur, I.; Bert, D.; Lagane, F.; Morneau, F.; Aury, J.-M.; Plomion, C.; Lascoux, M.; KREMER, A.
10.1101/2021.05.25.445558 — evolutionary biology — Posted on 2021-05-27
606 Measuring the exposure of primate reservoir hosts to mosquito vectors in Malaysian Borneo
Brown, R.; Ferguson, H.; Salgado-Lynn, M.; Tock-hing, C.; Vythilingam, I.; Jumail, A.; Jalius, C.
10.1101/2021.05.25.445315 — ecology — Posted on 2021-05-27
611 Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals
Planas, D.; Veyer, D.; Baidaliuk, A.; Staropoli, I.; Guivel-Benhassine, F.; Rajah, M.; Planchais, C.; Porrot, F.; Robillard, N.; Puech, J.; Prot, M.; Gallais, F.; Gantner, P.; Velay, A.; Le Guen, J.; Kassis-Chikhani, N.; Edriss, D.; Belec, L.; Seve, A.; Pere, H.; Courtellemenont, L.; Hocqueloux, L.; Fafi-Kremer, S.; Prazuck, T.; Mouquet, H.; Bruel, T.; Simon-Loriere, E.; Rey, F.; Schwartz, O.
10.1101/2021.05.26.445838 — microbiology — Posted on 2021-05-27
612 SARS-CoV-2 inactivation by human defensin HNP1 and retrocyclin RC-101
Kudryashova, E.; Zani, A.; Vilmen, G.; Sharma, A.; Lu, W.; Yount, J. S.; Kudryashov, D. S.
10.1101/2021.05.27.445985 — immunology — Posted on 2021-05-27
614 Effective interferon (IFN)-lambda treatment regimen to control lethal MERS-CoV infection in mice
Dijkman, R.; Selvaraj, M.; Gad, H. H.; More, S.; Hartmann, R.; Perlman, S.; Thiel, V.; Channappanavar, R.
10.1101/2021.05.26.445685 — immunology — Posted on 2021-05-27
620 How many replicates to accurately estimate fish biodiversity using environmental DNA on coral reefs?
Stauffer, S.; Jucker, M.; Keggin, T.; Marques, V.; Andrello, M.; Bessudo, S.; Cheutin, M.-C.; Borrero-Perez, G. H.; Richards, E.; Dejean, T.; Hocde, R.; Juhel, J.-B.; Ladino, F.; Loiseau, N.; Maire, E.; Mutis Martinezguerra, M.; Manel, S.; Polanco Fernandez, A.; Valentini, A.; Mouillot, D.; Velez, L.; Letessier, T. B.; Albouy, C.; Pellissier, L.; Waldock, C.
10.1101/2021.05.26.445742 — ecology — Posted on 2021-05-27
622 ERK1/2 is an ancestral organising signal in spiral cleavage
Seudre, O.; Carrillo-Baltodano, A. M.; Liang, Y.; Martin-Duran, J. M.
10.1101/2021.05.26.445819 — developmental biology — Posted on 2021-05-27
623 In vitro hepatotoxicity assessment of Lippia javanica (Burm.f.) Spreng. aqueous leaf extract
Swanepoel, B.; Koekemoer, T. C.; Venables, L.; Cloete, E.; Khumalo, N. P.; van de Venter, M.
10.1101/2021.05.26.445727 — cell biology — Posted on 2021-05-27
624 Induction of an immortalized songbird cell line allows for gene characterization and knockout by CRISPR-Cas9
Biegler, M. T.; Fedrigo, O.; Collier, P.; Mountcastle, J.; Haase, B.; Tilgner, H. U.; Jarvis, E. D.
10.1101/2021.05.27.445896 — cell biology — Posted on 2021-05-27
625 Differences in nanoscale organization of DNase I hypersensitive and insensitive chromatin in single human cells
Brandstetter, K.; Zuelske, T.; Ragoczy, T.; Hoerl, D.; Haugen, E.; Rynes, E.; Stamatoyannopoulos, J. A.; Leonhardt, H.; Wedemann, G.; Harz, H.
10.1101/2021.05.27.445943 — cell biology — Posted on 2021-05-27
630 Biological Constraints Can Improve Prediction inPrecision Oncology
Omar, M.; Mulder, L.; Coady, T.; Zanettini, C.; Imada, E. L.; Dinalankara, W.; Younes, L.; Geman, D.; Marchionni, L.
10.1101/2021.05.25.445604 — bioinformatics — Posted on 2021-05-27
631 Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes
Rawsthorne-Manning, H.; Calahorro, F.; G. Izquierdo, P.; Holden-Dye, L.; O'Connor, V.; Dillon, J.
10.1101/2021.05.26.445785 — genetics — Posted on 2021-05-27
632 Maximally predictive ensemble dynamics from data
Costa, A. C.; Ahamed, T.; Jordan, D.; Stephens, G. J.
10.1101/2021.05.26.445816 — biophysics — Posted on 2021-05-27
635 Actin dynamics as a multiscale integrator of cellular guidance cues
Bull, A. L.; Campanello, L.; Hourwitz, M. J.; Yang, Q.; Zhao, M.; Fourkas, J. T.; Losert, W.
10.1101/2021.05.26.445782 — biophysics — Posted on 2021-05-27
639 Genomic signatures of recent adaptation in a wild bumblebee
Colgan, T. J.; Arce, A. N.; Gill, R. J.; Ramos Rodrigues, A.; Kanteh, A.; Duncan, E. J.; Li, L.; Chittka, L.; Wurm, Y.
10.1101/2021.05.27.445509 — evolutionary biology — Posted on 2021-05-27
641 TCAB1 is necessary for telomerase assembly
Al-Masraf, B. S.; Perez, G. I.; Adams-Boone, K.; Cohen, S. B.; Han, L.; Yu, K.; Schmidt, J. C.
10.1101/2021.05.27.445986 — cell biology — Posted on 2021-05-27
642 Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii
Chen, X.; Liu, M.; Zhang, P.; Xu, M.; Yuan, W.; Bian, L.; Liu, Y.; Xia, J.; Leung, S. S. Y.
10.1101/2021.05.26.445908 — microbiology — Posted on 2021-05-27
644 Histone acetyltransferase activity of CREB-binding protein is essential for synaptic plasticity in Lymnaea
Hatakeyama, D.; Sunada, H.; Totani, Y.; Watanabe, T.; Felletar, I.; Fitchett, A.; Eravci, M.; Anagnostopoulou, A.; Miki, R.; Kuzuhara, T.; Kemenes, I.; Ito, E.; Kemenes, G.
10.1101/2021.05.26.445902 — neuroscience — Posted on 2021-05-27
645 Protein shape sampled by ion mobility mass spectrometry consistently improves protein structure prediction
Turzo, S. B. A.; Seffernick, J. T.; Rolland, A. D.; Donor, M. T.; Heinze, S.; Prell, J. S.; Wysocki, V. H.; Lindert, S.
10.1101/2021.05.27.445812 — biophysics — Posted on 2021-05-27
646 Single-molecule imaging of cholesterol-dependent cytolysin assembly
Senior, M. J.; Monico, C.; Weatherill, E. E.; Gilbert, R.; Heuck, A.; Wallace, M. I.
10.1101/2021.05.26.445776 — biophysics — Posted on 2021-05-27
648 A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
Chen, J.; Lambo, M. E.; Xia, G.; Dearborn, J. T.; Liu, Y.; McCullough, K. B.; Swift, R. G.; Tabachnick, D. R.; Tian, L.; Noguchi, K.; Garbow, J. R.; Gabel, H. W.; Hengen, K. B.; Maloney, S. E.; Dougherty, J. D.
10.1101/2020.12.17.423095 — neuroscience — Posted on 2021-05-27
649 Rhizobiales commensal bacteria promote Arabidopsis thaliana root growth via host sulfated peptide pathway
Hucklenbroich, J.; Gigolashvili, T.; Koprivova, A.; Spohr, P.; Nezamivand Chegini, M.; Klau, G. W.; Kopriva, S.; Nakano, R. T.
10.1101/2021.05.25.444716 — plant biology — Posted on 2021-05-27
650 GenomicSuperSignature: interpretation of RNA-seq experiments through robust, efficient comparison to public databases
Oh, S.; Geistlinger, L.; Ramos, M.; Taroni, J. N.; Carey, V. J.; Greene, C. S.; Waldron, L.; Davis, S. R.
10.1101/2021.05.26.445900 — bioinformatics — Posted on 2021-05-27
653 Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation
Noby, N.; Sabah Auhim, H.; Worthy, H.; Winter, S.; Embady, A.; Saeed, H.; Hussein, A.; Pudney, C.; Rizkallah, P.; Wells, S. A.; Jones, D.; Pudney, C. R.
10.1101/2021.02.23.432564 — biochemistry — Posted on 2021-05-27
654 Dopamine modulates adaptive forgetting in medial prefrontal cortex
Gallo, F. T.; Zanoni-Saad, M. B.; Morici, J. F.; Miranda, M.; Anderson, M. C.; Weisstaub, N. V.; Bekinschtein, P.
10.1101/2021.04.08.438979 — animal behavior and cognition — Posted on 2021-05-27
655 Transcriptional milestones in Dictyostelium development
Katoh-Kurasawa, M.; Hrovatin, K.; Hirose, S.; Webb, A.; Ho, H.-I.; Zupan, B.; Shaulsky, G.
10.1101/2021.05.27.445976 — genomics — Posted on 2021-05-27
656 Quantifying bacterial evolution in the wild: a birthday problem for Campylobacter lineages
Calland, J. K.; Pascoe, B.; Bayliss, S. C.; Mourkas, E.; Berthenet, E.; Thorpe, H. A.; Hitchings, M. D.; Feil, E. J.; Blaser, M. J.; Falush, D.; Sheppard, S. K.
10.1101/2020.12.02.407999 — genomics — Posted on 2021-05-27
657 An in vivo approach to characterize novel variants associated with musculoskeletal disorders
Johnson, A. N.; McAdow, J.; Yang, S.; Ou, T.; Huang, G.; Dobbs, M. B.; Gurnett, C.
10.1101/2021.05.27.445925 — genetics — Posted on 2021-05-27
658 Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes
Monti, R.; Rautenstrauch, P.; Ghanbari, M. L.; James, A. R.; Ohler, U.; Konigorski, S.; Lippert, C.
10.1101/2021.05.27.444972 — genetics — Posted on 2021-05-27
659 Notch controls the cell cycle to define leader versus follower identities during collective cell migration.
Alhashem, Z.; Feldner-Busztin, D.; Revell, C.; Alvarez-Garcillan Portillo, M.; Richardson, J.; Rocha, M.; Gauert, A.; Corbeaux, T.; Prince, V. E.; Bentley, K.; Linker, C.
10.1101/2021.05.27.445572 — developmental biology — Posted on 2021-05-27
660 Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
Garcia Morato, J.; Hans, F.; von Zweydorf, F.; Feederle, R.; Elsaesser, S. J.; Skodras, A. A.; Gloeckner, C. J.; Buratti, E.; Neumann, M.; Kahle, P. J.
10.1101/2020.05.26.104356 — cell biology — Posted on 2021-05-27
662 The evolution of the phenylpropanoid pathway entailed pronounced radiations and divergences of enzyme families
de Vries, S.; Fuerst-Jansen, J. M.; Irisarri, I.; Dhabalia Ashok, A.; Ischebeck, T.; Feussner, K.; Abreu, I. N.; Petersen, M.; Feussner, I.; de Vries, J.
10.1101/2021.05.27.445924 — plant biology — Posted on 2021-05-27
664 Evolutionary systems biology reveals patterns of rice adaptation to drought-prone agro-ecosystems
Groen, S. C.; Joly-Lopez, Z.; Platts, A. E.; Natividad, M.; Fresquez, Z.; Mauck, W. M.; Quintana, M. R.; Cabral, C. L.; Torres, R. O.; Satija, R.; Purugganan, M. D.; Henry, A.
10.1101/2021.05.26.445872 — plant biology — Posted on 2021-05-27
665 Adaptive divergence generates distinct plastic responses in two closely related Senecio species
Walter, G. M.; Clark, J.; Cristaudo, A.; Nevado, B.; Terranova, D.; Catara, S.; Paunov, M.; Velikova, V.; Filatov, D.; Cozzolino, S.; Hiscock, S.; Bridle, J. R.
10.1101/2020.01.24.918201 — evolutionary biology — Posted on 2021-05-27
670 Sylites: Multipurpose markers for the visualization of inhibitory synapses
Khayenko, V.; Schulte, C.; Reis, S. L.; Avraham, O.; Schietroma, C.; Worschech, R.; Nordblom, N. F.; Kachler, S.; Villmann, C.; Heinze, K.; Schlosser, A.; Furman-Schueler, O.; Tovote, P.; Specht, C. G.; Maric, H. M.
10.1101/2021.05.20.444651 — neuroscience — Posted on 2021-05-27
672 Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells.
Li, Q.; Feng, Y.; Xue, Y.; Zhan, X.; Fu, Y.; Gui, G.; Zhou, W.; Richard, J.-P.; Taga, A.; Li, P.; Mao, X.; Maragakis, N. J.; Ying, M.
10.1101/2021.05.09.443325 — neuroscience — Posted on 2021-05-27
675 Sir3 Heterochromatin Protein Promotes NHEJ by Direct Inhibition of Sae2
Bordelet, H.; Costa, R.; Brocas, C.; DEPAGNE, J.; Veaute, X.; BUSSO, D.; Batte, A.; Guerois, R.; Marcand, S.; Dubrana, K.
10.1101/2021.05.26.445723 — genetics — Posted on 2021-05-27
676 PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1
Kant, S.; Tran, K.-V.; Kvandova, M.; Caliz, A. D.; Yoo, H.-J.; Learnard, H.; Craige, S. M.; Hall, J. D.; Jimenez, J. M.; St. Hilaire, C.; Schulz, E.; Kroller-Schon, S.; Keaney, J. F.
10.1101/2021.05.26.445830 — cell biology — Posted on 2021-05-27
678 The 3D construction of leaves is coordinated with water use efficiency in conifers
Trueba, S.; Theroux-Rancourt, G.; Earles, J. M.; Buckley, T. N.; Love, D.; Johnson, D. M.; Brodersen, C.
10.1101/2021.04.23.441113 — plant biology — Posted on 2021-05-27
681 DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells
Tam, A. S.; Tsai, S.; Chang, E. Y.-C.; Mathew, V.; Shanks, A.; Docking, T. R.; Kumar, A.; Bernard, D. G.; Karsan, A.; Stirling, P. C.
10.1101/2021.05.26.445839 — cell biology — Posted on 2021-05-27
682 Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis
Ungricht, R.; Guibbal, L.; Lasbennes, M.-C.; Orsini, V.; Beibel, M.; Waldt, A.; Cuttat, R.; Carbone, W.; Basler, A.; Roma, G.; Nigsch, F.; Tchorz, J.; Hoepfner, D.; Hoppe, P. S.
10.1101/2021.05.26.445745 — cell biology — Posted on 2021-05-27
683 Location and function of all Plasmodium kinesins: key roles in parasite proliferation, polarity, and transmission
Zeeshan, M.; Rashpa, R.; Ferguson, D. J. P.; Abel, S.; Chahine, Z.; Brady, D.; Moores, C. A.; Le Roch, K. G.; Brochet, M.; Holder, A. A.; Tewari, R.
10.1101/2021.05.26.445751 — cell biology — Posted on 2021-05-27
685 A hierarchy of linguistic predictions during natural language comprehension
Heilbron, M.; Armeni, K.; Schoffelen, J.-M.; Hagoort, P.; de Lange, F. P.
10.1101/2020.12.03.410399 — neuroscience — Posted on 2021-05-27
687 Epigenetic Patterns in a Complete Human Genome
Gershman, A.; Sauria, M. E. G.; Hook, P. W.; Hoyt, S.; Razaghi, R.; Koren, S.; Altemose, N.; Caldas, G. V.; Vollger, M. R.; Logsdon, G.; Rhie, A.; Eichler, E.; Schatz, M.; O'Neill, R. J.; Phillippy, A. M.; Miga, K. H.; Timp, W.
10.1101/2021.05.26.443420 — genomics — Posted on 2021-05-27
688 EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in developing neurons
Parker, S. S.; Ly, K. T.; Grant, A. D.; Wang, A. M.; Parker, J. D.; Roman, M. R.; Padi, M.; Wolgemuth, C. W.; Langlais, P. R.; Mouneimne, G.
10.1101/2021.05.26.444586 — cell biology — Posted on 2021-05-27
689 Regional Differences in Brain Plasticity and Behaviour as a Function of Sex and Enrichment Type: Oxytocin Matters
Faraji, J.; Lotfi, H.; Moharrerie, A.; Jafari, Y.; Soltanpour, N.; Tamannaiee, R.; Marjani, K.; Roudaki, S.; Naseri, F.; Moeeini, R.; Metz, G. A. S.
10.1101/2021.05.26.445890 — neuroscience — Posted on 2021-05-27
690 LMO2 is critical for early metastatic events in breast cancer
Sikandar, S. S.; Antony, J.; Gulati, G. S.; Kuo, A.; Ho, W. H. D.; Das, S.; Steen, C. B.; Pereira, T. A.; Qian, D.; Beachy, P. A.; Dirbas, F.; Red-Horse, K.; Rabbitts, T. H.; Thiery, J. P.; Newman, A. M.; Clarke, M.
10.1101/2021.05.26.443198 — cancer biology — Posted on 2021-05-26
691 The complete sequence of a human genome
Nurk, S.; Koren, S.; Rhie, A.; Rautiainen, M.; Bzikadze, A. V.; Mikheenko, A.; Vollger, M. R.; Altemose, N.; Uralsky, L.; Gershman, A.; Aganezov, S.; Hoyt, S. J.; Diekhans, M.; Logsdon, G. A.; Alonge, M.; Antonarakis, S. E.; Borchers, M.; Bouffard, G. G.; Brooks, S. Y.; Caldas, G. V.; Cheng, H.; Chin, C.-S.; Chow, W.; de Lima, L. G.; Dishuck, P. C.; Durbin, R.; Dvorkina, T.; Fiddes, I. T.; Formenti, G.; Fulton, R. S.; Fungtammasan, A.; Garrison, E.; Grady, P. G. S.; Graves-Lindsay, T. A.; Hall, I. M.; Hansen, N. F.; Hartley, G. A.; Haukness, M.; Howe, K.; Hunkapiller, M. W.; Jain, C.; Jain, M.
10.1101/2021.05.26.445798 — genomics — Posted on 2021-05-27
694 Purification of immunostimulatory glucose homopolymer from broccoli (Brassica oleracea var. italica)
Miyashita, A.; Kataoka, K.; Tsuchida, T.; Ogasawara, A. A.; Hamamoto, H.; Takahashi, M.; Sekimizu, K.
10.1101/2021.05.26.445781 — biochemistry — Posted on 2021-05-26
695 Profiling Germline Adaptive Immune Receptor Repertoire with gAIRR Suite
Lin, M.-J.; Lin, Y.-C.; Chen, N.-C.; Luo, A. C.; Lai, S.-K.; Hsu, C.-L.; Hsu, J. S.; Chen, C.-Y.; Yang, W.-S.; Chen, P.-L.
10.1101/2020.11.27.399857 — genomics — Posted on 2021-05-26
696 TnCentral: A Prokaryotic Transposable Element Database and Web Portal for Transposon Analysis
Ross, K.; Varani, A. M.; Snesrud, E.; Huang, H.; Alvarenga, D. O.; Zhang, J.; Wu, C.; McGann, P.; Chandler, M. G.
10.1101/2021.05.26.445724 — genomics — Posted on 2021-05-26
698 Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni
Pagliazzo, L.; Caby, S.; Lancelot, J.; Salome-Desnoulez, S.; Saliou, J.-M.; Chassat, T.; Caillau, K.; Vicogne, J.; Pierce, R. J.
10.1101/2021.05.26.445767 — molecular biology — Posted on 2021-05-26
700 MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway
Chattopadhyay, S.; Mamidi, P.; Nayak, T. K.; Kumar, A.; Kumar, S.; Chatterjee, S.; De, S.; Datey, A.; Laha, E.; Ray, A.; Chattopadhyay, S.
10.1101/2021.05.26.445768 — microbiology — Posted on 2021-05-26
701 Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques
Nomura, T.; Yamamoto, H.; Nishizawa, M.; Hau, T.; Harada, S.; Ishii, H.; Seki, S.; Nakamura-Hoshi, M.; Okazaki, M.; Daigen, S.; Kawana-Tachikawa, A.; Nagata, N.; Iwata-Yoshikawa, N.; Shiwa, N.; Iida, S.; Katano, H.; Suzuki, T.; Park, E.-S.; Maeda, K.; Suzaki, Y.; Ami, Y.; Matano, T.
10.1101/2021.05.26.445769 — microbiology — Posted on 2021-05-26
702 Decomposing age effects in EEG alpha power
Tröndle, M.; Popov, T.; Pedroni, A.; Pfeiffer, C.; Baranczuk-Turska, Z.; Langer, N.
10.1101/2021.05.26.445765 — neuroscience — Posted on 2021-05-26
703 Comparison of linear combination modeling strategies for GABA-edited MRS at 3T
Zöllner, H. J.; Tapper, S.; Hui, S. C. N.; Barker, P. B.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2021.05.26.445817 — biochemistry — Posted on 2021-05-26
704 A robust method for performing 1H-NMR lipidomics in embryonic zebrafish
Morgan, R. S.; Walmsley, G. L.; Peffers, M. J.; Barrett-Jolley, R.; Phelan, M. M.
10.1101/2021.05.26.445770 — biochemistry — Posted on 2021-05-26
708 Age and infectious dose significantly affect disease progression after RHDV2 infection in naive domestic rabbits
Hall, R. N.; King, T.; O'Connor, T.; Read, A. J.; Arrow, J.; Trought, K.; Duckworth, J.; Piper, M.; Strive, T.
10.1101/2021.05.26.445897 — microbiology — Posted on 2021-05-26
710 The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection
Phan, Q. T.; Lin, J.; Solis, N. V.; Eng, M.; Swidergall, M.; Wang, F.; LI, S.; Gaffen, S. L.; Chou, T.-F.; Filler, S. G.
10.1101/2021.05.25.445718 — microbiology — Posted on 2021-05-26
714 TatA and TatB generate a hydrophobic mismatch that is important for function and assembly of the Tat translocon in Escherichia coli
Mehner-Breitfeld, D.; Ringel, M. T.; Tichy, D. A.; Endter, L. J.; Stroh, K. S.; Luensdorf, H.; Risselada, H. J.; Brueser, T.
10.1101/2021.05.26.445790 — biochemistry — Posted on 2021-05-26
717 Diversity, taxonomy and evolution of archaeal viruses of the class Caudoviricetes
Liu, Y.; Demina, T. A.; Roux, S.; Aiewsakun, P.; Kazlauskas, D.; Simmonds, P.; Prangishvili, D.; Oksanen, H. M.; Krupovic, M.
10.1101/2021.05.26.445827 — microbiology — Posted on 2021-05-26
719 The fate of Hepatitis E virus capsid protein is regulated by an Arginine-Rich Motif
Hervouet, K.; Ferrie, M.; Ankavay, M.; Montpellier, C.; Camuzet, C.; Alexandre, V.; Dembele, A.; Lecoeur, C.; Foe, A. T.; Bouquet, P.; Hot, D.; Vausselin, T.; Saliou, J.-M.; Salome-Desnoulez, S.; Marsollier, L.; Brodin, P.; Dreux, M.; Rouille, Y.; Dubuisson, J.; Aliouat-Denis, C.-M.; Cocquerel, L.
10.1101/2021.05.26.445820 — microbiology — Posted on 2021-05-26
727 Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism
Tejedor-Sanz, S.; Stevens, E. T.; Finnegan, P.; Nelson, J. J.; Knoessen, A.; Light, S. H.; Ajo-Franklin, C. M.; Marco, M. L.
10.1101/2021.05.26.445846 — microbiology — Posted on 2021-05-26
728 Systemic infection with highly pathogenic H5N8 of avian origin produces encephalitis and mortality in wild mammals at a UK rehabilitation centre
Floyd, T.; Banyard, A. C.; Lean, F. Z.; Byrne, A. M.; Fullick, E.; Whittard, E.; Mollet, B. C.; Bexton, S.; Swinson, V.; Macrelli, M.; Lewis, N. S.; Reid, S. M.; Nunez, A.; Duff, J. P.; Hansen, R.; Brown, I. H.
10.1101/2021.05.26.445666 — microbiology — Posted on 2021-05-26
730 Complex structure of the Bacillus subtilis CdaA c-di-AMP cyclase domain and the phosphoglucomutase GlmM
Pathania, M.; Tosi, T.; Millership, C.; Hoshiga, F.; Morgan, R. M. L.; Freemont, P. S.; Grundling, A.
10.1101/2021.05.26.445777 — microbiology — Posted on 2021-05-26
731 SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation
Li, T.-W.; Kenney, A. D.; Liu, H.; Fiches, G. N.; Zhou, D.; Biswas, A.; Que, J.; Santoso, N.; Yount, J. S.; Zhu, J.
10.1101/2021.05.26.445787 — microbiology — Posted on 2021-05-26
732 Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima, Peru
Jara, L. M.; Ferradas, C.; Schiaffino, F.; Sanchez-Carrion, C.; Martinez, A.; Ulloa, A.; Isasi-Rivas, G.; Montalvan, A.; Sarmiento, L. G.; Fernandez Diaz, M. C.; Zimic, M.
10.1101/2021.05.26.445880 — immunology — Posted on 2021-05-26
733 Attentional brain rhythms during prolonged cognitive activity
Gaillard, C.; De Sousa, C.; Amengual, J.; Loriette, C.; Ziane, C.; Ben Hadj Hassen, S.; Di Bello, F.; Ben Hamed, S.
10.1101/2021.05.26.445730 — neuroscience — Posted on 2021-05-26
734 Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration
Liu, X. l.; Zu, E.; Chang, X. Y.; Wang, Z. Q.; Li, X. R.; Yu, Q.; Kamei, K.-i.; Hayashi, T.; Mizuno, K.; Hattori, S.; Fujisaki, H.; Ikejima, T.; Wang, D. O.
10.1101/2021.05.26.445744 — physiology — Posted on 2021-05-26
735 Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner
Savva, C.; Helguero, L. A.; Gonzalez-Granillo, M.; Melo, T.; Couto, D.; Angelin, B.; Domingues, M. R.; Li, X.; Kutter, C.; Korach-Andre, M.
10.1101/2021.05.26.445738 — physiology — Posted on 2021-05-26
736 Demuxalot: scaled up genetic demultiplexing for single-cell sequencing
Rogozhnikov, A.; Ramkumar, P.; Shah, K.; Bedi, R.; Kato, S.; Escola, S.
10.1101/2021.05.22.443646 — bioinformatics — Posted on 2021-05-26
737 Effective prophylaxis of COVID-19 in rhesus macaques using a combination of two parentally-administered SARS-CoV-2 neutralizing antibodies
Beddingfield, B. J.; Maness, N. J.; Fears, A. C.; Rappaport, J.; Aye, P. P.; Russell-Lodrigue, K. E.; Doyle-Meyers, L. A.; Blair, R. V.; Carias, A. M.; Redondo, R. L.; Madden, P. J.; Gao, H.; Montefiori, D.; Hope, T. J.; ROY, C. J.
10.1101/2021.05.26.445878 — microbiology — Posted on 2021-05-26
738 Identifying dysregulated immune cell subsets following critical volumetric muscle loss with pseudo-time trajectories
Hymel, L. A.; Anderson, S. E.; Turner, T. C.; York, W. Y.; Lim, H. S.; Qiu, P.; Jang, Y. C.; Willett, N. J.; Botchwey, E. A.
10.1101/2021.05.25.445480 — immunology — Posted on 2021-05-26
739 Impaired function and delayed regeneration of dendritic cells in COVID-19
Winheim, E.; Rinke, L.; Lutz, K.; Reischer, A.; Leutbecher, A.; Wolfram, L.; Rausch, L.; Kranich, J.; Wratil, P. R.; Huber, J.; Baumjohann, D.; Rothenfusser, S.; Hellmuth, J.; Scherer, C.; Muenchhoff, M.; von Bergwelt-Baildon, M.; Stark, K.; Straub, T.; Brocker, T.; Keppler, O. T.; Subklewe, M.; Krug, A. B.
10.1101/2021.05.26.445809 — immunology — Posted on 2021-05-26
740 Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence
Talla, A.; Vasaikar, S. V.; Lemos, M. P.; Moodie, Z.; Pebworth, M.-P. L.; Henderson, K. E.; Cohen, K. W.; Czartoski, J. L.; Lai, L.; Suthar, M. S.; Heubeck, A. T.; Genge, P. C.; Roll, C. M.; Weiss, M.; Reading, J.; Kondza, N.; MacMillan, H.; Fong, O. C.; Thomson, Z. J.; Graybuck, L. T.; Newell, E. W.; Coffey, E. M.; Meijer, P.; Becker, L. A.; De Rosa, S. C.; Torgerson, T. R.; Skene, P. J.; Li, X.; Szeto, G. L.; McElrath, M. J.; Bumol, T. F.
10.1101/2021.05.26.442666 — immunology — Posted on 2021-05-26
741 Sex Differences in Functional Topography of Association Networks
Shanmugan, S.; Seidlitz, J.; Cui, Z.; Adebimpe, A.; Bassett, D. S.; Bertolero, M. A.; Davatzikos, C.; Fair, D. A.; Gur, R. E.; Gur, R. C.; Larsen, B.; Li, H.; Pines, A. R.; Raznahan, A.; Roalf, D. R.; Shinohara, R. T.; Vogel, J.; Wolf, D. H.; Fan, Y.; Alexander-Bloch, A.; Satterthwaite, T. D.
10.1101/2021.05.25.445671 — neuroscience — Posted on 2021-05-26
743 Brain capillary obstruction as a novel mechanism of anti-CD19 CAR T cell neurotoxicity
Faulhaber, L. D.; Hartsuyker, K. J.; Phuong, A. Q.; Cho, Y.; Mand, K. K.; Harper, S. D.; Olson, A. K.; Garden, G. A.; Shih, A.; Gust, J.
10.1101/2021.05.25.445614 — neuroscience — Posted on 2021-05-26
746 Fibronectin meshwork controls epithelial stem cell fate
Estrach, S.; Tosello, L.; Tissot, F. S.; Cailleteau, L.; Cervera, L.; Jensen, K. B.; Feral, C. C.
10.1101/2021.05.26.445735 — physiology — Posted on 2021-05-26
748 Mechanical counterbalance of kinesin and dynein motors in microtubular network regulates cell mechanics, 3D architecture, and mechanosensing
Zhovmer, A. S.; Manning, A.; Smith, C.; Hayes, J. B.; Burnette, D. T.; Cartagena-Rivera, A. X.; Singh, R. K.; Tabdanov, E. D.
10.1101/2021.05.25.445700 — biophysics — Posted on 2021-05-26
749 Comparative transcriptome analysis of noble crayfish and marbled crayfish immune response to Aphanomyces astaci challenges
Bostjancic, L. L.; Francesconi, C.; Rutz, C.; Hoffbeck, L.; Poidevin, L.; Kress, A.; Jussila, J.; Makkonen, J.; Feldmeyer, B.; Balint, M.; Lecompte, O.; Theissinger, K.
10.1101/2021.05.25.445163 — bioinformatics — Posted on 2021-05-26
755 Single-cell RNA-sequencing reveals thoracolumbar vertebra heterogeneity and rib-genesis in pigs
Li, J.; Wang, L.; Yu, D.; Hao, J.; Zhang, L.; Adeola, A. C.; Mao, B.; Gao, Y.; Wu, S.; Zhu, C.; Zhang, Y.; Ren, J.; Mu, C.; Irwin, D. M.; Wang, L.; Hai, T.; Xie, H.; Zhang, Y.-p.
10.1101/2021.05.25.445704 — developmental biology — Posted on 2021-05-26
758 Towards increased shading potential: a combined phenotypic and genetic analysis of rice shoot architecture
Huber, M.; Julkowska, M. M.; Snoek, B. L.; van Veen, H.; Toulotte, J.; Kumar, V.; Kajala, K.; Sasidharan, R.; Pierik, R.
10.1101/2021.05.25.445664 — plant biology — Posted on 2021-05-26
760 An Issue of Concern: Unique Truncated ORF8 Protein Variants of SARS-CoV-2
Hassan, S. S.; Kodakandla, V.; Redwan, E. M.; Lundstrom, K.; Pal Choudhury, P.; Abd El-Aziz, T. M.; Takayama, K.; Kandimalla, R.; Lal, A.; Serrano-Aroca, A.; Azad, G. K.; Aljabali, A. A. A.; Palu, G.; Chauhan, G.; Adadi, P.; Tambuwala, M.; Brufsky, A.; Baetas-da-Cruz, W.; Barh, D.; Bazan, N. G.; Uversky, V. N.
10.1101/2021.05.25.445557 — bioinformatics — Posted on 2021-05-26
761 CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes
Djekidel, M. N.; Rosikiewicz, W.; Peng, J. C.; Kanneganti, T.-D.; Hui, Y.; Jin, H.; Hedges, D.; Schreiner, P.; Fan, Y.; Wu, G.; Xu, B.
10.1101/2021.05.14.444026 — bioinformatics — Posted on 2021-05-26
765 Localization and RNAi-driven inhibition of a Brugia malayi encoded Interleukin-5 Receptor Binding protein
Mejia, R.; Bennuru, S.; Oksov, Y.; Lustigman, S.; Munirathinam, G.; Kalyanasundaram, R.; Nutman, T. B.
10.1101/2021.05.13.443627 — molecular biology — Posted on 2021-05-26
766 REGEN-COV protects against viral escape in preclinical and human studies
Copin, R.; Baum, A.; Wloga, E.; Pascal, K. E.; Giordano, S.; Fulton, B. O.; Zhou, A.; Negron, N.; Lanza, K.; Chan, N.; Coppola, A.; Chiu, J.; Ni, M.; Atwal, G. S.; Romero Hernandez, A.; Saotome, K.; Zhou, Y.; Franklin, M. C.; Hooper, A. T.; McCarthy, S.; Hamon, S.; Hamilton, J. D.; Staples, H. M.; Alfson, K.; Carrion, R.; Ali, S.; Norton, T.; Somersan-Karakaya, S.; Sivapalasingam, S.; Herman, G. A.; Weinreich, D. M.; Lipsich, L.; Stahl, N.; Murphy, A. J.; Yancopoulos, G. D.; Kyratsous, C. A.
10.1101/2021.03.10.434834 — microbiology — Posted on 2021-05-26
767 Multispecific DARPin(R) therapeutics demonstrate very high potency against SARS-CoV-2 variants in vitro
Rothenberger, S.; Walser, M.; Malvezzi, F.; Mayor, J.; Ryter, S.; Moreno, H.; Liechti, N.; Halg, S.; Bosshart, A.; Iss, C.; Calabro, V.; Cornelius, A.; Hospodarsch, T.; Neculcea, A.; Looser, T.; Herrup, R.; Lusvarghi, S.; Nath Neerukonda, S.; Vassell, R.; Wang, W.; Reichen, C.; Radom, F.; Dawson, K. M.; Lewis, S.; Steiner, D.; Amstutz, P.; Weiss, C. D.; Engler, O.; Stumpp, M. T.
10.1101/2021.02.03.429164 — immunology — Posted on 2021-05-26
769 An interpretable connectivity-based decoding model for classification of chronic marijuana use
Kulkarni, K. R.; Schafer, M.; Berner, L.; Fiore, V. G.; Heflin, M.; Hutchison, K.; Calhoun, V.; Filbey, F.; Pandey, G.; Schiller, D.; Gu, X.
10.1101/2021.05.04.442433 — neuroscience — Posted on 2021-05-26
770 CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates inflammation and transcriptional dysregulation in Huntington's disease
Yu, D.; Zarate, N.; Cuccu, F.; Yue, J. S.; Brown, T. G.; Tsai, W.; Mansky, R.; Jiang, K.; Kim, H.; White, A.; Nanclares, C.; Nichols-Meade, T.; Larson, S. N.; Gundry, K.; Zhang, Y.; Tomas-Zapico, C.; Lucas, J. J.; Benneyworth, M.; Öz, G.; Cvetanovic, M.; Araque, A.; Gomez-Pastor, R.
10.1101/2020.10.29.359380 — neuroscience — Posted on 2021-05-26
771 Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples
Wilson, E. R.; Helton, N.; Heath, S. E.; Fulton, R. S.; Miller, C.; Payton, J. E.; Welch, J. S.; Walter, M.; Westervelt, P.; DiPersio, J. F.; Link, D. C.; Ley, T. J.; Spencer, D. H.
10.1101/2021.03.03.433799 — cancer biology — Posted on 2021-05-26
775 Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types
Sinha, N.; Sinha, S.; Mayor, C. V.; Schaffer, A. A.; Aldape, K.; Litchfield, K.; Chan, T.; Morris, L. G. T.; Ruppin, E.
10.1101/2021.05.25.445197 — cancer biology — Posted on 2021-05-26
776 Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5
Galiani, S.; Reglinski, K.; Carravilla, P.; Barbotin, A.; Urbancic, I.; Ott, J.; Sehr, J.; Sezgin, E.; Schneider, F.; Waithe, D.; Hublitz, P.; Schliebs, W.; Erdmann, R.; Eggeling, C.
10.1101/2021.05.25.445571 — biophysics — Posted on 2021-05-26
777 Computational Design Map for Heterogeneous Experimental Studies
Kulkarni, C.; Maisha, N.; Schaub, L. J.; Glaser, J.; Lavik, E.; Janeja, V.
10.1101/2021.05.25.445627 — bioengineering — Posted on 2021-05-26
779 Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat.
Chandran, V.; Bermudez, M.-L.; Koka, M.; Chandran, B.; Pawale, D.; Vishnubhotla, R.; Alankar, S.; Maturi, R.; Subramaniam, B.; Sadhasivam, S.
10.1101/2021.05.18.444668 — genomics — Posted on 2021-05-26
781 Segmental duplications and their variation in a complete human genome
Vollger, M. R.; Guitart, X.; Dishuck, P. C.; Mercuri, L.; Harvey, W. T.; Gershman, A.; Diekhans, M.; Sulovari, A.; Munson, K. M.; Lewis, A. M.; Hoekzema, K.; Porubsky, D.; Li, R.; Nurk, S.; Koren, S.; Miga, K. H.; Phillippy, A. M.; Timp, W.; Ventura, M.; Eichler, E. E.
10.1101/2021.05.26.445678 — genomics — Posted on 2021-05-26
789 Genomic sequence characteristics and the empiric accuracy of short-read sequencing
Marin, M. G.; Vargas, R.; Harris, M.; Jeffrey, B.; Epperson, L. E.; Durbin, D.; Strong, M.; Salfinger, M.; Iqbal, Z.; Akhundova, I.; Vashakidze, S.; Crudu, V.; Rosenthal, A.; Farhat, M. R.
10.1101/2021.04.08.438862 — bioinformatics — Posted on 2021-05-26
791 Bioluminescent Synthetic Cells Communicate with Natural Cells and Self-Activate Light-Responsive Proteins
Adir, O.; Abel, R.; Albalak, M. R.; Weiss, L. E.; Chen, G.; Gruber, A.; Staufer, O.; Shklover, J.; Shainsky-Roitman, J.; Platzman, I.; Gepstein, L.; Shechtman, Y.; Horwitz, B. A.; Schroeder, A.
10.1101/2021.05.20.444896 — bioengineering — Posted on 2021-05-26
792 Framework for Rapid Comparison of Extracellular Vesicle Isolation Methods
Ter-Ovanesyan, D.; Norman, M.; Lazarovits, R.; Trieu, W.; Lee, J.; Church, G.; Walt, D. R.
10.1101/2020.10.13.337881 — biochemistry — Posted on 2021-05-26
796 Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression
Tu, J.; Li, W.; Yang, S.; Yang, P.; Yan, Q.; Wang, S.; Lai, K.; Bai, X.; Wu, C.; Ding, W.; Cooper-White, J.; Diwan, A.; Yang, C.; Yang, H.; Zou, J.
10.1101/2021.05.25.445620 — cell biology — Posted on 2021-05-26
799 Magnetic Field Mapping and Correction for Moving OP-MEG
Mellor, S. J.; Tierney, T. M.; O'Neill, G. C.; Alexander, N.; Seymour, R. A.; Holmes, N.; Lopez, J. D.; Hill, R. M.; Boto, E.; Rea, M.; Roberts, G.; Leggett, J.; Bowtell, R.; Brookes, M. J.; Maguire, E. A.; Walker, M. C.; Barnes, G. R.
10.1101/2021.05.25.444975 — neuroscience — Posted on 2021-05-26
800 Hematopoietic differentiation is characterized by a transient peak of cell-to-cell gene expression variability in normal and pathological conditions.
Dussiau, C.; Boussaroque, A.; Gaillard, M.; Bravetti, C.; Zaroili, L.; Knosp, C.; Friedrich, C.; Asquier, P.; Willems, L.; Quint, L.; Bouscary, D.; Fontenay, M.; Espinasse, T.; Plesa, A.; Sujobert, P.; Gandrillon, O.; Kosmider, O.
10.1101/2021.04.30.442092 — systems biology — Posted on 2021-05-26
802 MASiVar: Multisite, Multiscanner, and Multisubject Acquisitions for Studying Variability in Diffusion Weighted Magnetic Resonance Imaging
Cai, L. Y.; Yang, Q.; Kanakaraj, P.; Nath, V.; Newton, A. T.; Edmonson, H. A.; Luci, J.; Conrad, B. N.; Price, G. R.; Hansen, C. B.; Kerley, C. I.; Ramadass, K.; Yeh, F.-C.; Kang, H.; Garyfallidis, E.; Descoteaux, M.; Rheault, F.; Schilling, K. G.; Landman, B. A.
10.1101/2020.12.03.408567 — bioengineering — Posted on 2021-05-26
804 Characterizing the spatial signal of environmental DNA in river systems using a community ecology approach
Cantera, I.; Decotte, J.-B.; Dejean, T.; Murienne, J.; Vigouroux, R.; Valentini, A.; Brosse, S.
10.1101/2020.10.11.333047 — ecology — Posted on 2021-05-26
807 Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
Krieger, T. G.; LeBlanc-Soto, S.; Jabs, J.; Ten, F. W.; Ishaque, N.; Jechow, K.; Debnath, O.; Leonhardt, C.-S.; Giri, A.; Eils, R.; Strobel, O.; Conrad, C.
10.1101/2020.08.23.263160 — cancer biology — Posted on 2021-05-26
814 A quantitative review of abundance-based species distribution models
Waldock, C.; Stuart-Smith, R. D.; Albouy, C.; Cheung, W. W. L.; Edgar, G. J.; Mouillot, D.; Tjiputra, J.; Pellissier, L.
10.1101/2021.05.25.445591 — ecology — Posted on 2021-05-26
817 Feasibility of FreeSurfer processing for T1-weighted brain images of 5-year-olds: semiautomated protocol of FinnBrain Neuroimaging Lab
Pulli, E. P.; Silver, E.; Kumpulainen, V.; Copeland, A.; Merisaari, H.; Saunavaara, J.; Parkkola, R.; Lahdesmaki, T.; Saukko, E.; Nolvi, S.; Kataja, E.-L.; Korja, R.; Karlsson, L.; Karlsson, H.; Tuulari, J. J.
10.1101/2021.05.25.445419 — neuroscience — Posted on 2021-05-26
820 Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.
Strutzenberg, T. S.; Novick, S. J.; Garcia-Ordonez, R. D.; Doebelin, C.; He, Y.; Chang, M. R.; Kamenecka, T. M.; Griffin, P. R.
10.1101/2021.05.25.445650 — biophysics — Posted on 2021-05-26
825 PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEB-induced Autophagy-Lysosomal Pathway
Chung, H. T.; Do, M.; Park, J.; Chen, Y.; Rah, S.-Y.; Nghiem, T.-H. T.; Gong, J. H.; Kim, B.-S.; Park, J. W.; Ryter, S. W.; Surh, Y.-J.; Kim, U.-H.; Joe, Y.
10.1101/2021.05.25.445568 — neuroscience — Posted on 2021-05-26
827 Tapping into non-English-language science for the conservation of global biodiversity
Amano, T.; Berdejo Espinola, V.; Christie, A. P.; Willott, K.; Akasaka, M.; Baldi, A.; Berthinussen, A.; Bertolino, S.; Bladon, A. J.; Chen, M.; Choi, C.-Y.; Bou Dagher Kharrat, M.; de Oliveira, L. G.; Farhat, P.; Golivets, M.; Hidalgo Aranzamendi, N.; Jantke, K.; Kajzer-Bonk, J.; Kemahli Aytekin, M. C.; Khorozyan, I.; Kito, K.; Konno, K.; Lin, D.-L.; Littlewood, N.; Liu, Y.; Liu, Y.; Loretto, M.-C.; Marconi, V.; Martin, P.; Morgan, W. H.; Narvaez-Gomez, J. P.; Negret, P.; Nourani, E.; Ochoa Quintero, J. M.; Ockendon, N.; Oh, R.; Petrovan, S.; Piovezan-Borges, A. C.; Pollet, I. L.; Ramos, D. L
10.1101/2021.05.24.445520 — scientific communication and education — Posted on 2021-05-26
828 Peripheral Coupling Sites Formed by STIM1 Govern the Contractility of Vascular Smooth Muscle Cells
Krishnan, V.; Ali, S.; Gonzales, A. L.; Thakore, P.; Griffin, C. S.; Yamasaki, E.; Alvarado, M. G.; Johnson, M. T.; Trebak, M.; Earley, S.
10.1101/2021.05.25.445565 — physiology — Posted on 2021-05-26
831 Comprehensive assessment of Indian variations in the druggable kinome landscape highlights distinct insights at the sequence, structure and pharmacogenomic stratum
Panda, G.; Mishra, N.; Sharma, D.; Bhoyar, R. C.; Jain, A.; Imran, M.; Senthilvel, V.; Divakar, M. K.; Mishra, A.; Garg, P.; Banerjee, P.; Sivasubbu, S.; Scaria, V.; Ray, A.
10.1101/2021.05.23.445314 — genomics — Posted on 2021-05-26
832 Maximizing genetic representation in seed collections from populations of self and cross-pollinated banana wild relatives
Kallow, S.; Panis, B.; Vu Dang, T.; Vu Dang, T.; Paofa, J.; Mertens, A.; Swennen, R.; Janssens, S.
10.1101/2021.05.25.445549 — genetics — Posted on 2021-05-26
836 Gaining or cutting SLAC: the evolution of plant guard cell signalling pathways
Sussmilch, F. C.; Maierhofer, T.; Herrmann, J.; Voss, L. J.; Lind, C.; Messerer, M.; Mueller, H. M.; Buenner, M. S.; Ache, P.; Mayer, K. F. X.; Becker, D.; Roelfsema, M. R. G.; Geiger, D.; Schultz, J.; Hedrich, R.
10.1101/2021.05.26.445736 — plant biology — Posted on 2021-05-26
837 GmSALT3 expression improves reactive oxygen species detoxification in salt-stressed soybean roots
Qu, Y.; Yu, L.; Guan, R.; Berkowitz, O.; david, r.; Whelan, J.; ford, m.; Wege, S.; Qiu, L.; Gilliham, M.
10.1101/2021.05.26.445725 — plant biology — Posted on 2021-05-26
838 Neurotrophin signaling is modulated by specific transmembrane domain interactions
Franco, M. L.; Nadezhdin, K. D.; Light, T. P.; Goncharuk, S. A.; Soler-Lopez, A.; Ahmed, F.; Mineev, K. S.; Hristova, K.; Arseniev, A. S.; Vilar, M.
10.1101/2021.05.24.445441 — biochemistry — Posted on 2021-05-26
839 Exploring the evolution and adaptive role of mosaic aneuploidy in a clonal Leishmania donovani population using high throughput single-cell genome sequencing
Negreira, G. H.; Monsieurs, P.; Imamura, H.; Maes, I.; Kuk, N.; Yagoubat, A.; Van den Broeck, F.; Sterkers, Y.; Dujardin, J.-C.; Domagalska, M. A.
10.1101/2020.03.05.976233 — genomics — Posted on 2021-05-26
841 Ambient light and mimicry as drivers of wing transparency in Lepidoptera
Arias, M.; Barbut, J.; Rougerie, R.; Dutry, M.; Kohler, M.; Laulan, B.; Paillard, C.; Berthier, S.; Andraud, C.; Elias, M.; Gomez, D.
10.1101/2020.06.26.172932 — evolutionary biology — Posted on 2021-05-26
842 Phenotypic plasticity triggers rapid morphological convergence
Gomez, J.-M.; Gonzalez-Megias, A.; Narbona, E.; Navarro, L.; Perfectti, F.; Armas, C.
10.1101/2021.05.25.445642 — evolutionary biology — Posted on 2021-05-26
843 A potential prokaryotic and microsporidian pathobiome that may cause shrimp white feces syndrome (WFS)
Prachumwat, A.; Munkongwongsiri, N.; Eamsaard, W.; lertsiri, K.; Flegel, T. W.; Stentiford, G. D.; Sritunyalucksana, K.
10.1101/2021.05.23.445355 — molecular biology — Posted on 2021-05-26
846 Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans
Bermejo-Jambrina, M.; Eder, J.; Kaptein, T. M.; van Hamme, J. L.; Helgers, L. C.; Vlaming, K. E.; Brouwer, P. J.; Vlaar, A. P.; van Baarle, F. E. H. P.; Spaargaren, M.; de Bree, G. J.; Nijmeijer, B. M.; Kootstra, N. A.; van Gils, M. J.; Sanders, R. W.; Geijtenbeek, T. B. H.
10.1101/2020.08.18.255810 — immunology — Posted on 2021-05-26
847 Binocular Mirror-Symmetric Microsaccadic Sampling of Hyperacute 3D-Vision
Kemppainen, J.; Scales, B.; Razban Haghighi, K.; Takalo, J.; Mansour, N.; McManus, J.; Leko, G.; Saari, P.; Hurcomb, J.; Antohi, A.; Suuronen, J.-P.; Blanchard, F.; Hardie, R. C.; Song, Z.; Hampton, M.; Eckermann, M.; Westermeier, F.; Frohn, J.; Hoekstra, H.; Lee, C.-H.; Huttula, M.; Mokso, R.; Juusola, M.
10.1101/2021.05.03.442473 — neuroscience — Posted on 2021-05-26
848 Dynamics of Functional Network Organization Through Graph Mixture Learning
Ricchi, I.; Tarun, A.; Petric Maretic, H.; Frossard, P.; Van De Ville, D.
10.1101/2021.05.25.445303 — neuroscience — Posted on 2021-05-26
850 Proteome dynamics during antibiotic persistence and resuscitation
Semanjski, M.; Gratani, F.; Englert, T.; Nashier, P.; Beke, V.; Nalpas, N.; Germain, E.; George, S. E.; Wolz, C.; Gerdes, K.; Macek, B.
10.1101/2020.09.04.282723 — microbiology — Posted on 2021-05-26
852 Transcript- and annotation-guided genome assembly of the European starling
Stuart, K. C.; Edwards, R. J.; Cheng, Y.; Warren, W. C.; Burt, D. W.; Sherwin, W. B.; Hofmeister, N. R.; Werner, S. J.; Ball, G. F.; Bateson, M.; Brandley, M. C.; Buchanan, K. L.; Cassey, P.; Clayton, D. F.; De Meyer, T.; Meddle, S. L.; Rollins, L. A.
10.1101/2021.04.07.438753 — genomics — Posted on 2021-05-26
854 Motor usage imprints microtubule stability in the shaft
Andreu-Carbo, M.; Fernandes, S.; Celluz, M.-C.; Kruse, K.; Aumeier, C.
10.1101/2021.04.09.439170 — cell biology — Posted on 2021-05-26
855 Loneliness and the social brain: how perceived social isolation impairs human interactions
Lieberz, J.; Shamay-Tsoory, S. G.; Saporta, N.; Esser, T.; Kuskova, E.; Stoffel-Wagner, B.; Hurlemann, R.; Scheele, D.
10.1101/2021.03.03.433569 — neuroscience — Posted on 2021-05-26
859 Expansion of the prime editing modality with Cas9 from Francisella novicida
Oh, Y.; Lee, W.-j.; Kim, H.; Gwon, L. W.; Kim, Y.-H.; Park, Y.-H.; Kim, C. H.; Lim, K.-S.; Song, B.-S.; Huh, J.-W.; Kim, S.-U.; Jun, B.-H.; Jung, C.; Lee, S.
10.1101/2021.05.25.445577 — bioengineering — Posted on 2021-05-25
861 Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate Retriever-mediated recycling on endosomes
Giridharan, S. S. P.; Luo, G. S.; Rivero-Rios, P. S.; Steinfeld, N. S.; Tronchere, H.; Singla, A.; Burstein, E.; Billadeau, D.; Sutton, M. A.; Weisman, L. S.
10.1101/2021.05.25.445615 — cell biology — Posted on 2021-05-25
862 Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells
Lopez, A. J.; Kim, S.; Qian, X.; Rogers, J.; Stout, J. T.; Thomasy, S. M.; La Torre, A.; Chen, R.; Moshiri, A.
10.1101/2021.05.25.445693 — cell biology — Posted on 2021-05-25
864 Virus-Dependent Immune Conditioning of Tissue Microenvironments
Jiang, S.; Chan, C. N.; Rovira-Clave, X.; Chen, H.; Bai, Y.; Zhu, B.; McCaffrey, E.; Greenwald, N. F.; Liu, C.; Barlow, G. L.; Weirather, J. L.; Busman-Sahay, K.; Nekorchuk, M.; Terry, M.; Younger, S.; Oliveria, J. P.; Bosse, M.; Demeter, J.; Philips, D.; Mukherjee, N.; Golstev, Y.; McIlwain, D. R.; Angelo, M.; Estes, J. D.; Nolan, G. P.
10.1101/2021.05.21.444548 — immunology — Posted on 2021-05-25
867 Detection of Small Fiber Neuronal Activity with Optically Pumped Magnetometers
Bu, Y.; Borna, A.; Schwindt, P.; Zeng, X.; Huang, M.; Baum, E.; Rao, R.; Kimball, D.; Shah, V.; Lerman, I.
10.1101/2021.05.18.444539 — neuroscience — Posted on 2021-05-25
869 Impact of Type II LRRK2 inhibitors on signalling and mitophagy
Tasegian, A.; Singh, F.; Ganley, I.; Reith, A. D.; Alessi, D. R.
10.1101/2021.05.21.445132 — neuroscience — Posted on 2021-05-25
870 Functional characterization of RELN missense mutations involved in recessive and dominant forms of Neuronal Migration Disorders
Riva, M.; Ferreira, S.; Medvedeva, V. P.; Causeret, F.; Henry, O. J.; Roux, C.-J.; Bellesme, C.; Freri, E.; Parrini, E.; Josifova, D.; Guerrini, R.; Bahi-Buisson, N.; Pierani, A.
10.1101/2021.05.25.445586 — neuroscience — Posted on 2021-05-25
871 Survey and Molecular Detection of Sri Lankan Cassava Mosaic Virus in Thailand
Siriwan, W.; Saokham, K.; Hemniam, N.; Roekwan, S.; Hunsawattanakul, S.; Thawinampan, J.
10.1101/2021.05.25.445583 — pathology — Posted on 2021-05-25
875 recount3: summaries and queries for large-scale RNA-seq expression and splicing
Wilks, C.; Zheng, S. C.; Chen, F. Y.; Charles, R.; Solomon, B.; Ling, J. P.; Imada, E. L.; Zhang, D.; Joseph, L.; Leek, J. T.; Jaffe, A. E.; Nellore, A.; Collado-Torres, L.; Hansen, K. D.; Langmead, B.
10.1101/2021.05.21.445138 — genomics — Posted on 2021-05-25
876 Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment
Lazure, F.; Farouni, R.; Sahinyan, K.; Blackburn, D. M.; Hernandez-Corchado, A.; Perron, G.; Ragoussis, J.; Crist, C.; Perkins, T. J.; Jahani-Asl, A.; Najafabadi, H. S.; Soleimani, V. D.
10.1101/2021.05.25.445621 — genetics — Posted on 2021-05-25
877 Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P2 by a phosphotransferase
Walpole, G.; Pacheco, J.; Chauhan, N.; Abbas, Y.; Montano-Rendon, F.; Liu, Z.; Zhu, H.; Brumell, J. H.; Deiters, A.; Hammond, G. R.; Grinstein, S.; Fairn, G. D.
10.1101/2021.05.25.445663 — cell biology — Posted on 2021-05-25
879 Locus-associated R-loop repression in cis
Khosraviani, N.; Abraham, K. J.; Chan, J. N. Y.; Mekhail, K.
10.1101/2021.05.25.445644 — molecular biology — Posted on 2021-05-25
880 DNA extraction and host depletion methods significantly impact and potentially bias bacterial detection in a biological fluid
Ganda, E.; Beck, K. L.; Haiminen, N.; Silverman, J. D.; Kawas, B.; Cronk, B.; Anderson, R. R.; Goodman, L. B.; Wiedmann, M.
10.1101/2020.08.21.262337 — molecular biology — Posted on 2021-05-25
882 A metabolomics pipeline enables mechanistic interrogation of the gut microbiome
Han, S.; Van Treuren, W.; Fischer, C. R.; Merrill, B. D.; DeFelice, B. C.; Sanchez, J. M.; Higginbottom, S. K.; Guthrie, L.; Fall, L. A.; Dodd, D.; Fischbach, M. A.; Sonnenburg, J. L.
10.1101/2021.05.25.445684 — microbiology — Posted on 2021-05-25
883 Diversity of satellite glia in sympathetic and sensory ganglia
Mapps, A.; Thomsen, M.; Boehm, E.; Zhao, H.; Hattar, S.; Kuruvilla, R.
10.1101/2021.05.25.445647 — neuroscience — Posted on 2021-05-25
885 Positive Selection and Heat-Response Transcriptomes Reveal Adaptive Features of the Arabidopsis Desert Relative, Anastatica hierochuntica
Eshel, G.; Duppen, N.; Wang, G.; Oh, D.-H.; Kazachkova, Y.; Herzyk, P.; Amtmann, A.; Gordon, M.; Chalifa-Caspi, V.; Oscar, M. A.; Bar-David, S.; Marshall-Colon, A.; Dassanayake, M.; Barak, S.
10.1101/2021.05.23.445339 — plant biology — Posted on 2021-05-25
889 Variation in upstream open reading frames contributes to allelic diversity in protein abundance
Gage, J. L.; Mali, S.; McLoughlin, F.; Khaipho-Burch, M.; Monier, B.; Bailey-Serres, J.; Vierstra, R. D.; Buckler, E. S.
10.1101/2021.05.25.445499 — genomics — Posted on 2021-05-25
894 Evaluation of podocyte Rac-1 induced kidney disease by modulation of TRPC5
Reiser, J.; Polat, O. K.; Isaeva, E.; Zhu, K.; Noben, M.; Sudhini, Y.; Samelko, B.; Kumar, V. S.; Wei, C.; Altintas, M. M.; Dryer, S. E.; Sever, S.; Staruschenko, A.
10.1101/2021.05.25.445694 — cell biology — Posted on 2021-05-25
896 Redundant and specific roles of EGFR ligands in the ERK activation waves during collective cell migration of MDCK cells
Lin, S.; Hirayama, D.; Maryu, G.; Matsuda, K.; Hino, N.; Deguchi, E.; Aoki, K.; Iwamoto, R.; Terai, K.; Matsuda, M.
10.1101/2021.05.25.445569 — cell biology — Posted on 2021-05-25
897 Structural basis for target-site selection in RNA-guided DNA transposition systems
Park, J.-U.; Tsai, A.; Mehrotra, E.; Petassi, M. T.; Hsieh, S.-C.; Ke, A.; Peters, J. E.; Kellogg, E. H.
10.1101/2021.05.25.445634 — molecular biology — Posted on 2021-05-25
898 Salmonella Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance
Shelton, C. D.; Yoo, W.; Shealy, N. G.; Torres, T. P.; Zieba, J. K.; Calcutt, M. W.; Foegeding, N. J.; Kim, D.; Kim, J.; Ryu, S.; Byndloss, M. X.
10.1101/2021.05.25.445690 — microbiology — Posted on 2021-05-25
899 Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States
White, B.; Sterrett, J.; Grigoryan, Z.; Lally, L.; Heinze, J.; Alikhan, H.; Lowry, C.; Perez, L. J.; DeSipio, J.; Phadtare, S.
10.1101/2021.05.23.445270 — microbiology — Posted on 2021-05-25
901 An infection-activated redox switch promotes tumor growth
Kovalyova, Y.; Bak, D. W.; Gordon, E. M.; Fung, C.; Shuman, J. H. B.; Cover, T. L.; Amieva, M. R.; Weerapana, E.; Hatzios, S. K.
10.1101/2021.05.25.445662 — microbiology — Posted on 2021-05-25
902 Divergent early antibody responses define COVID-19 disease trajectories
Chakraborty, S.; Gonzalez, J. C.; Sievers, B. L.; Mallajosyula, V.; Dubey, M.; Cheng, Y.-L. B.; Tran, K. Q. T.; Chakraborty, S.; Cassidy, A.; Chen, S. T.; Sinnott, A.; Gelbart, T.; Golan, Y.; Prahl, M.; Singh, U.; Kim-Schulze, S.; Sherwood, R.; Zhang, S.; Marron, T. U.; Gnjatic, S.; Gaw, S. L.; Nadeau, K. C.; Merad, M.; Jagannathan, P.; Tan, G. S.; Wang, T. T.
10.1101/2021.05.25.445649 — immunology — Posted on 2021-05-25
903 The extracellular ATP receptor P2RX7 imprints a pro-memory transcriptional signature in effector CD8+ T cells
Vardam-Kaur, T.; van Dijk, S.; Peng, C.; Wanhainen, K. M.; Jameson, S. C.; Borges da Silva, H.
10.1101/2021.05.25.445679 — immunology — Posted on 2021-05-25
905 Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway
Wang, S.; van Rhijn, J.-R.; Akkouh, I. A.; Kogo, N.; Maas, N.; bleeck, A.; Lewerissa, E.; Wu, K. M.; Schoenmaker, C.; Djurovic, S.; van Bokhoven, H.; Kleefstra, T.; Kasri, N. N.; Schubert, D.
10.1101/2021.05.25.445613 — neuroscience — Posted on 2021-05-25
907 A photo-switchable yeast isocitrate dehydrogenase to control metabolic flux through the citric acid cycle
Chen, H.; Mulder, L.; Wijma, H. J.; Wabeke, R.; Vila Cha Losa, J. P.; Rovetta, M.; de Leeuw, T. C.; Milias-Argeitis, A.; Heinemann, M.
10.1101/2021.05.25.445643 — synthetic biology — Posted on 2021-05-25
908 Infection of brain pericytes underlying neuropathology of COVID-19 patients
Bocci, M.; Oudenaarden, C.; Saenz-Sarda, X.; Simren, J.; Eden, A.; Sjölund, J.; Möller, C.; Gisslen, M.; Zetterberg, H.; Englund, E.; Pietras, K.
10.1101/2021.05.24.445532 — pathology — Posted on 2021-05-25
911 Genomic Surveillance of COVID-19 Variants with Language Models and Machine Learning
Nagpal, S.; Pal, R.; Ashima, ; Tyagi, A.; Tripathi, S.; Nagori, A.; Ahmad, S.; Mishra, H. P.; Kutum, R.; Sethi, T.
10.1101/2021.05.25.445601 — bioinformatics — Posted on 2021-05-25
914 Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1
Huang, F.; Nguyen, T. N. N.; Echeverria, I.; Ramachandran, R.; Cary, D. C.; Paculova, H.; Sali, A.; Weiss, A.; Peterlin, B. M.; Fujinaga, K.
10.1101/2021.05.25.445695 — biochemistry — Posted on 2021-05-25
915 Identification of site-specific evolutionary trajectories shared across human betacoronaviruses
Escalera-Zamudio, M.; Kosakovsky Pond, S. L.; Martinez de la Vina, N.; Gutierrez, B.; Theze, J.; Bowden, T. A.; Pybus, O. G.; Hulswit, R. J. G.
10.1101/2021.05.24.445313 — evolutionary biology — Posted on 2021-05-25
917 Impact of Glycosylation on SARS-CoV-2 Infection and Broadly Protective Vaccine Design
Liao, H.-Y.; Huang, H.-Y.; Chen, X.; Cheng, C.-W.; Wang, S.-W.; Shahed-Al-Mahmud, M.; Chen, T.-H.; Lo, J. M.; Liu, Y.-M.; Ma, H.-H.; Chang, Y.-H.; Tsai, C.-Y.; Huang, P.-Y.; Chang, S.-Y.; Chao, T.-L.; Kao, H.-C.; Tsai, Y.-M.; Chen, Y.-H.; Chen, C.-Y.; Lee, K.-C.; Wu, C.-Y.; Jan, J.-T.; Lin, K.-I.; Cheng, T.-J. R.; Ma, C.; Wong, C.-H.
10.1101/2021.05.25.445523 — microbiology — Posted on 2021-05-25
919 An Issue of Concern: Unique Truncated ORF8 Protein Variants of SARS-CoV-2
Hassan, S. S.; Kodakandla, V.; Redwan, E. M.; Lundstrom, K.; Pal Choudhury, P.; Abd El-Aziz, T. M.; Takayama, K.; Kandimalla, R.; Lal, A.; Serrano-Aroca, A.; Azad, G. K.; Aljabali, A. A. A.; Palu, G.; Chauhan, G.; Adadi, P.; Tambuwala, M.; Brufsky, A.; Baetas-da-Cruz, W.; Barh, D.; Bazan, N. G.; Uversky, V. N.
10.1101/2021.05.25.445557 — bioinformatics — Posted on 2021-05-25
920 A simple permutation-based test of intermodal correspondence
Weinstein, S. M.; Vandekar, S. N.; Adebimpe, A.; Tapera, T. M.; Robert-Fitzgerald, T.; Gur, R. C.; Gur, R. E.; Raznahan, A.; Satterthwaite, T. D.; Alexander-Bloch, A. F.; Shinohara, R. T.
10.1101/2020.09.10.285049 — neuroscience — Posted on 2021-05-25
921 NMDARs expressed in Granule Cells are involved in cerebellar plasticity and motor learning
Schonewille, M.; Girasole, A. E.; Rostaing, P.; Mailhes-Hamon, C.; Ayon, A.; Nelson, A. B.; Triller, A.; Casado, M.; De Zeeuw, C. I.; Bouvier, G.
10.1101/2021.01.12.426386 — neuroscience — Posted on 2021-05-25
922 Sparse Epistatic Regularization of Deep Neural Networks for Inferring Fitness Functions
Aghazadeh, A.; Nisonoff, H.; Ocal, O.; Brookes, D. H.; Huang, Y.; Koyluoglu, O. O.; Listgarten, J.; Ramchandran, K.
10.1101/2020.11.24.396994 — bioinformatics — Posted on 2021-05-25
924 Contributions of h- and Na+/K+ pump currents to the generation of episodic and continuous rhythmic activities
Sharples, S. A.; Parker, J.; Vargas, A.; Lognon, A. P.; Cheng, N.; Young, L.; Shonak, A.; Cymbalyuk, G. S.; Whelan, P. J.
10.1101/2020.09.08.288266 — neuroscience — Posted on 2021-05-25
926 Sorghum Root Epigenetic Landscape During Limiting Phosphorus Conditions
Gladman, N. P.; Hufnagel, B.; Regulski, M.; Liu, Z.; Wang, X.; Chougule, K.; Kochian, L. V.; Magalhaes, J.; Ware, D.
10.1101/2021.05.25.445633 — plant biology — Posted on 2021-05-25
927 Proliferation impairs cell viability via energy depletion
Galichon, P.; Lannoy, M.; Li, L.; Vandermeersch, S.; Legouis, D.; Valerius, M. T.; Hadchouel, J.; Bonventre, J. V.
10.1101/2020.04.24.054643 — physiology — Posted on 2021-05-25
928 Rhizobiales commensal bacteria promote Arabidopsis thaliana root growth via host sulfated peptide pathway
Hucklenbroich, J.; Gigolashvili, T.; Koprivova, A.; Spohr, P.; Nezamivand Chegini, M.; Klau, G. W.; Kopriva, S.; Nakano, R. T.
10.1101/2021.05.25.444716 — plant biology — Posted on 2021-05-25
929 Phototropin-mediated perception of light direction in Arabidopsis leaves regulates blade flattening
Fankhauser, C.; Legris, M.; Szarzynska-Erden, B. M.; Trevisan, M.; Allenbach Petrolati, L.
10.1101/2021.05.25.445665 — plant biology — Posted on 2021-05-25
930 Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors
Carter, A. M.; Kumar, N.; Herring, B.; Tan, C.; Guenter, R.; Telange, R.; Howse, W.; Viol, F.; Graham, C.; McCaw, T. R.; Bickerton, h.; Gillardon, F.; Woltering, E. A.; Totenhagen, J.; Banerjee, R.; Kurian, E.; Reddy, S.; Chen, H.; Schrader, J.; Rose, J. B.; Mukhtar, M. S.; Bibb, J.
10.1101/2021.05.25.445594 — cancer biology — Posted on 2021-05-25
933 An mRNA SARS-CoV-2 vaccine employing Charge-Altering Releasable Transporters with a TLR-9 agonist induces neutralizing antibodies and T cell memory
Haabeth, O.; Lohmeyer, J.; Sallets, A.; Blake, T.; Sagiv-Barfi, I.; Czerwinski, D.; McCarthy, B.; Powell, A. E.; Wender, P. A.; Waymouth, R. M.; Levy, R.
10.1101/2021.04.14.439891 — immunology — Posted on 2021-05-25
935 Targeting the nociceptive somatosensory system with AAV9 and AAV2retro viral vectors
Skorput, A. G.-J.; Gore, R.; Schorn, R.; Riedl, M. S.; de Velasco, E. M. F.; Hadlich, B.; Kitto, K. F.; Fairbanks, C. A.; Vulchanova, L.
10.1101/2021.05.25.445559 — neuroscience — Posted on 2021-05-25
938 CellMap: Characterizing the types and composition of iPSC-derived cells from RNA-seq data
Ouyang, Z.; Bourgeois, N.; Lyashenko, E.; Cundiff, P.; Cullen, P. F.; Challa, R.; Li, K.; Zhang, X.; Casey, F.; Engle, S.; Zhang, B.; Zavodszky, M. I.
10.1101/2021.05.24.445360 — bioinformatics — Posted on 2021-05-25
939 Self-Supervised Pretraining for Transferable Quantitative Phase Image Cell Segmentation
Vicar, T.; Chmelik, J.; Jakubicek, R.; Chmelikova, L.; Gumulec, J.; Balvan, J.; Provaznik, I.; Kolar, R.
10.1101/2021.05.24.445397 — bioinformatics — Posted on 2021-05-25
943 Language barriers in global bird conservation
Negret, P. J.; Atkinson, S. C.; Woodworth, B.; Corella Tor, M.; Allan, J.; Fuller, R.; Amano, T.
10.1101/2021.05.24.445290 — ecology — Posted on 2021-05-25
944 A method for single molecule localization microscopy of tissues reveals nonrandom distribution of nuclear pores in Drosophila
Cheng, J.; Allgeyer, E. S.; Richens, J. H.; Dzafic, E.; Palandri, A.; Lewkow, B.; Sirinakis, G.; St Johnston, D.
10.1101/2021.05.24.445468 — cell biology — Posted on 2021-05-25
945 Interactions between TULP3 tubby domain cargo site and ARL13B amphipathic helix promote lipidated protein transport to cilia
Palicharla, V. R.; Hwang, S.-h.; Somatilaka, B. N.; Badgandi, H. B.; Legue, E.; Tran, V. M.; Woodruff, J. B.; Liem, K. F.; Mukhopadhyay, S.
10.1101/2021.05.25.445488 — cell biology — Posted on 2021-05-25
951 Seizures initiate in zones of relative hyperexcitation in a zebrafish epilepsy model
Niemeyer, J. E.; Gadamsetty, P.; Chun, C.; Sylvester, S.; Lucas, J. P.; Ma, H.; Schwartz, T. H.; Aksay, E.
10.1101/2021.03.30.437750 — neuroscience — Posted on 2021-05-25
953 Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice
Mason, W. J.; Jafree, D. J.; Pomeranz, G.; Kolatsi-Joannou, M.; Pacheco, S.; Moulding, D. A.; Wolf, A.; Kupatt, C.; Peppiatt-Wildman, C.; Papakrivopoulou, E.; Riley, P. R.; Long, D. A.; Vasilopoulou, E.
10.1101/2021.05.24.445384 — physiology — Posted on 2021-05-25
957 The molecular mechanism of load adaptation by branched actin networks
Li, T.-D.; Bieling, P.; Weichsel, J.; Mullins, R. D.; Fletcher, D. A.
10.1101/2021.05.24.445507 — biophysics — Posted on 2021-05-25
958 Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes
Huber, S. T.; Sarajlic, E.; Huijink, R.; Weis, F.; Evers, W. H.; Jakobi, A. J.
10.1101/2021.05.25.444805 — biophysics — Posted on 2021-05-25
963 Linguistic Analysis of the bioRxiv Preprint Landscape
Nicholson, D. N.; Rubinetti, V.; Hu, D.; Thielk, M.; Hunter, L. E.; Greene, C. S.
10.1101/2021.03.04.433874 — bioinformatics — Posted on 2021-05-25
964 Optimized liquid and gas phase fractionation increase HLA-peptidome coverage for primary cell and tissue samples
Klaeger, S.; Apffel, A.; Clauser, K. R.; Sarkizova, S.; Oliveira, G.; Rachimi, S.; Le, P. M.; Tarren, A.; Chea, V.; Abelin, J. G.; Braun, D. A.; Ott, P. A.; Keshishian, H.; Hacohen, N.; Keskin, D.; Wu, C. J.; Carr, S. A.
10.1101/2021.05.25.445487 — biochemistry — Posted on 2021-05-25
965 Dissection of multiple sclerosis genetics identifies B and CD4 T cells as driver cell subsets
Guo, M.; Sama, P.; LaBarre, B.; Lokhande, H.; Balibalos, J.; Chu, C.; Du, X.; Kheradpour, P.; Kim, C.; Oniskey, T.; Snyder, T.; Soghoian, D.; Weiner, H.; Chitnis, T.; Patsopoulos, N.
10.1101/2021.05.24.445445 — genetics — Posted on 2021-05-25
968 Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
Phillips, A. M.; Lawrence, K. R.; Moulana, A.; Dupic, T.; Chang, J.; Johnson, M. S.; Cvijovic, I.; Mora, T.; Walczak, A. M.; Desai, M. M.
10.1101/2021.05.25.445596 — evolutionary biology — Posted on 2021-05-25
970 Soft limbal niche maintains stem cell compartmentalization and function through YAP
Bhattacharya, S.; Mukherjee, A.; Pisano, S.; Altshuler, A.; Nasser, W.; Dey, S.; Kaganovsky, A.; Amitai-Lange, A.; Mimouni, M.; Socea, S.; Hasson, P.; Feral, C.; Wolfenson, H.; Shalom-Feuerstein, R.
10.1101/2021.05.25.445490 — cell biology — Posted on 2021-05-25
971 Interactions between TULP3 tubby domain cargo site and ARL13B amphipathic helix promote lipidated protein transport to cilia
Palicharla, V. R.; Hwang, S.-h.; Somatilaka, B. N.; Badgandi, H. B.; Legue, E.; Tran, V. M.; Woodruff, J. B.; Liem, K. F.; Mukhopadhyay, S.
10.1101/2021.05.25.445488 — cell biology — Posted on 2021-05-25
977 The formation of microbial exoskeletons is driven by a controlled calcium-concentrating subcellular niche
Keren-Paz, A.; Cohen-Cymberknoh, M.; Kolodkin-Gal, D.; Peretz, S.; Karunker, I.; Wolf, S. G.; Olender, T.; Kapishnikov, S.; Brumfeld, V.; Dersch, S.; Kartvelishvily, E.; Green-Zelinger, P.; Isola-Adeyanju, D.; Suissa, R.; Shteinberg, M.; Mcleod, D.; Patrauchan, M.; Zamir, G.; Gal, A.; Graumann, P.; Kerem, E.; Kolodkin-Gal, I.
10.1101/2020.01.08.898569 — microbiology — Posted on 2021-05-25
978 SARS-like coronaviruses in horseshoe bats (Rhinolophus spp.) in Russia, 2020.
Alkhovsky, S. V.; Lenshin, S. V.; Romashin, A. V.; Vishnevskaya, T. V.; Vyshemirsky, O. I.; Bulycheva, Y. I.; Lvov, D. K.; Gitelman, A. K.
10.1101/2021.05.17.444362 — microbiology — Posted on 2021-05-25
980 A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects
Pryce, K. D.; Kang, H. J.; Sakloth, F.; Liu, Y.; Khan, S.; Toth, K.; Kapoor, A.; Nicolais, A.; Che, T.; Qin, L.; Bertherat, F.; Kaniskan, H. U.; Jin, J.; Cameron, M.; Roth, B. L.; Zachariou, V.; Filizola, M.
10.1101/2021.05.24.445057 — neuroscience — Posted on 2021-05-25
981 INTEROCEPTIVE INFORMATION OF PHYSICAL VIGOR: OREXIN NEURONS GAUGE CIRCULATING IGF-I FOR MOTIVATIONAL MOTOR OUTPUT
Zegarraa Valdivia, J. A.; Fernandes, J.; Esparza, J.; Suda, K.; Fernandez de Sevilla, M. E.; Diaz-Pacheco, S.; Aleman, I. T.
10.1101/2021.05.25.445442 — neuroscience — Posted on 2021-05-25
982 Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea
Garrido-Charles, A.; Huet, A. T.; Matera, C.; Thirumalai, A.; Llebaria, A.; Moser, T.; Gorostiza, P.
10.1101/2021.05.25.445123 — neuroscience — Posted on 2021-05-25
983 Estimating anisotropy directly via neural timeseries
Fagerholm, E. D.; Foulkes, W. M. C.; Gallero-Salas, Y.; Helmchen, F.; Moran, R. J.; Friston, K. J.; Leech, R.
10.1101/2021.05.25.445605 — neuroscience — Posted on 2021-05-25
984 The Phtheirospermum japonicum isopentenyltransferase PjIPT1a regulates host cytokinin responses in Arabidopsis
Greifenhagen, A.; Braunstein, I.; Pfannstiel, J.; Yoshida, S.; Shirasu, K.; Schaller, A.; Spallek, T.
10.1101/2021.05.24.445531 — plant biology — Posted on 2021-05-25
985 miRNA-34c suppresses osteosarcoma progression in vivo by targeting Notch and E2F
Bae, Y.; Zeng, H.-C.; Chen, Y.-T.; Ketkar, S.; Munivez, E.; Yu, Z.; Gannon, F. H.; Lee, B. H.
10.1101/2021.05.24.445452 — cancer biology — Posted on 2021-05-25
986 Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer
Wu, R.; Guo, W.; Qiu, X.; Wang, S.; Sui, C.; Lian, Q.; Wu, J.; Shan, Y.; Yang, Z.; Yang, S.; Wu, T.; Wang, K.; Zhu, Y.; Wang, S.; Liu, C.; Zhang, Y.; Zheng, B.; Li, Z.; Zhang, Y.; Shen, S.; Zhao, Y.; Wang, W.; Bao, J.; Hu, J.; Wu, X.; Jiang, X.; Wang, H.; Gu, J.; Chen, L.
10.1101/2021.05.24.445446 — cancer biology — Posted on 2021-05-25
987 CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women
Abou-Fadel, J.; Grajeda, B.; Jiang, X.; Cailing-De La O, A.-M.; Flores, E.; Padarti, A.; Bhalli, M.; Le, A.; Zhang, J.
10.1101/2021.05.24.445510 — cancer biology — Posted on 2021-05-25
990 Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases
Xiang, X.; Arakhamia, T.; Carlomagno, Y.; Dhingra, S.; Thierry, M.; DeTure, M.; Cook, C. N.; Dickson, D. W.; Petrucelli, L.; Fitzpatrick, A.
10.1101/2021.05.24.445353 — biophysics — Posted on 2021-05-25
991 Structural basis for DNA targeting by the Tn7 transposon
Shen, Y.; Gomez-Blanco, J.; Petassi, M. T.; Peters, J. E.; Ortega, J.; Guarne, A.
10.1101/2021.05.24.445525 — biophysics — Posted on 2021-05-25
993 Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics
Dindo, M.; Pascarelli, S.; Chiasserini, D.; Grottelli, S.; Costantini, C.; Uechi, G.-I.; Giardina, G.; Laurino, P.; Cellini, B.
10.1101/2021.05.24.445519 — biochemistry — Posted on 2021-05-25
994 Vimentin binds to G-quadruplex repeats found at telomeres and gene promoters
Ceschi, S.; Berselli, M.; Giantin, M.; Toppo, S.; Spolaore, B.; Sissi, C.
10.1101/2021.05.25.444966 — biochemistry — Posted on 2021-05-25
998 Strong attraction of male mosquitoes (Aedes aegypti) to humans
Amos, B. A.; Hoffmann, A. A.; Staunton, K. M.; Lau, M.-J.; Burkot, T. R.; Ross, P. A.
10.1101/2021.05.24.445527 — animal behavior and cognition — Posted on 2021-05-25
999 The Telomere Length Landscape of Localized Prostate Cancer
Livingstone, J.; Shiah, Y.-J.; Yamaguchi, T. N.; Heisler, L. E.; Huang, V.; Lesurf, R.; Drysdale, E.; Green, J.; van der Kwast, T.; Bristow, R. G.; Fraser, M.; Boutros, P. C.
10.1101/2021.05.22.445239 — genomics — Posted on 2021-05-25
1001 Chromatin forms nanoscale three-dimensional packing domains with fractal-like scaling behavior in vitro
Li, Y.; Agrawal, V.; Virk, R. K. A.; Roth, E. W.; Eshein, A.; Frederick, J.; Huang, K.; Almassalha, L.; Bleher, R.; Carignano, M. A.; Szleifer, I. G.; Dravid, V. P.; Backman, V.
10.1101/2021.05.24.445538 — genomics — Posted on 2021-05-25
1003 Distinct mechanoreceptor pezo-1 isoforms modulate food intake in the nematode Caenorhabditis elegans
Hughes, K. J.; Shah, A.; Bai, X.; Adams, J.; Bauer, R.; Jackson, J.; Bainbridge, C.; Harris, E.; Ficca, A.; Freebairn, P.; Mohammed, S.; Fernandez, E. M.; Brocco, M.; Stein, W.; Vidal-Gadea, A. G.
10.1101/2021.05.24.445504 — genetics — Posted on 2021-05-25
1012 Undivided attention: The temporal effects of attention dissociated from decision, memory, and expectation
Moerel, D.; Grootswagers, T.; Robinson, A. K.; Shatek, S. M.; Woolgar, A.; Carlson, T. A.; Rich, A. N.
10.1101/2021.05.24.445376 — neuroscience — Posted on 2021-05-25
1014 GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging
Charles, A. S.; Cermak, N.; Affan, R.; Scott, B.; Schiller, J.; Mishne, G.
10.1101/2021.05.24.445514 — neuroscience — Posted on 2021-05-25
1016 Integrative functional analysis uncovers metabolic differences between Candida species
Begum, N.; Lee, S.; Pellon, A.; Sadeghi Nasab, S.; Nielsen, J.; Uhlen, M.; Moyes, D.; Shoaie, S.
10.1101/2021.05.24.445215 — systems biology — Posted on 2021-05-25
1019 Extremely potent human monoclonal antibodies for the prophylaxis and therapy of Tetanus
Pirazzini, M.; Grinzato, A.; Corti, D.; Barbieri, S.; Leka, O.; Vallese, F.; Tonellato, M.; Silacci Fregni, C.; Piccoli, L.; Kandiah, E.; Schiavo, G.; Zanotti, G.; Lanzavecchia, A.; Montecucco, C.
10.1101/2021.05.24.445390 — pathology — Posted on 2021-05-25
1020 Cancer Prognosis According to Parthanatos Features
Messikommer, A.; Maru, B.; Seipel, K.; Valk, P. J. M.; Theocharides, A.; Pabst, T.; McKeague, M.; Luedtke, N. W.
10.1101/2021.05.24.445484 — cancer biology — Posted on 2021-05-25
1023 CuAAC stabilization of an NMR mixed labeled dimer
Sapienza, P. J.; Currie, M. M.; Li, K.; Aubè, J.; Lee, A. L.
10.1101/2021.05.24.445505 — biophysics — Posted on 2021-05-25
1024 Visualizing the Role of Lipid Dynamics during Infrared Neural Stimulation with Hyperspectral Stimulated Raman Scattering Microscopy
Adams, W. R.; Gautam, R.; Locke, A. K.; Borrachero-Conejo, A. I.; Dollinger, B. R.; Throckmorton, G. A.; Duvall, C.; Jansen, E. D.; Mahadevan-Jansen, A.
10.1101/2021.05.24.444984 — biophysics — Posted on 2021-05-25
1026 Maximum Parsimony Reconciliation in the DTLOR Model
Liu, J.; Mawhorter, R.; Liu, I.; Santichaivekin, S.; Bush, E.; Libeskind-Hadas, R.
10.1101/2021.05.23.445352 — bioinformatics — Posted on 2021-05-25
1037 Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Rausser, S.; Trumpff, C.; McGill, M. A.; Junker, A.; Wang, W.; Ho, S.-H.; Mitchell, A.; Karan, K. R.; Monk, C.; Segerstrom, S. C.; Reed, R. G.; Picard, M.
10.1101/2020.10.16.342923 — cell biology — Posted on 2021-05-25
1038 ABO blood group is involved in the quality of the specific immune response
Gil-Manso, S.; Miguens Blanco, I.; Motyka, B.; Halpin, A.; Lopez-Estaban, R.; Perez-Fernandez, V. A.; Carbonell-Munoz, D.; Lopez-Fernandez, L. A.; west, L. J.; Correa-Rocha, R.; Pion, M.
10.1101/2021.05.23.445114 — immunology — Posted on 2021-05-25
1039 On the intersection between data quality and dynamical modelling of large-scale fMRI signals
Aquino, K. M.; Fulcher, B. D.; Oldham, S.; Parkes, L. M.; Gollo, L.; Deco, G.; Fornito, A.
10.1101/2021.05.23.445373 — neuroscience — Posted on 2021-05-25
1040 Multiple Causal Variants Underlie Genetic Associations in Humans
Abell, N. S.; DeGorter, M. K.; Gloudemans, M.; Greenwald, E.; Smith, K. S.; He, Z. S.; Montgomery, S. B.
10.1101/2021.05.24.445471 — genetics — Posted on 2021-05-25
1041 The Molecular Logic Organizing the Functional Compartmentalization of Reciprocal Synapses
Wang, C. Y.; Trotter, J. H.; Liakath-Ali, K.; Lee, S.-j.; Liu, X.; Südhof, T. C.
10.1101/2021.05.24.445461 — neuroscience — Posted on 2021-05-25
1043 High throughput single-cell genome sequencing gives insights into the generation andevolution of mosaic aneuploidy in Leishmania donovani
Negreira, G. H.; Monsieurs, P.; Imamura, H.; Maes, I.; Kuk, N.; Yagoubat, A.; Van den Broeck, F.; Sterkers, Y.; Dujardin, J.-C.; Domagalska, M. A.
10.1101/2021.05.11.443577 — genomics — Posted on 2021-05-25
1045 Processing of Pain by the Developing Brain: Evidence of Differences Between Adolescent and Adult Females
Tong, H.; Maloney, T. C.; Payne, M. F.; King, C. D.; Ting, T. V.; Kashikar-Zuck, S.; Coghill, R. C.; Lopez-Sola, M.
10.1101/2021.05.14.444209 — neuroscience — Posted on 2021-05-25
1052 A panel of single nucleotide polymorphism (SNP) markers identifies potential duplicates in cassava (Manihot esculenta Crantz) varieties from Cote dIvoire
Mutuku, J. M.; YEO, E.; AMOAKON, W.; PITA, J.; NZUE, B.; KOUASSI, M.; YAO, N.; OTRON, D.; SHAH, T.; VANIE-LEABO, L.; KPAHE, K.; SIE, R.; SORHO, F.; KONE, D.; NGUETTA, S.-P.; FERGUSON, M.
10.1101/2021.05.24.445412 — plant biology — Posted on 2021-05-24
1054 Membrane phase separation drives organization at B cell receptor clusters
Shelby, S. A.; Castello-Serrano, I.; Wisser, K.; Levental, I.; Veatch, S.
10.1101/2021.05.12.443834 — biophysics — Posted on 2021-05-24
1057 Standardized genome-wide function prediction enables comparative functional genomics: a new application area for Gene Ontologies in plants
Fattel, L.; Psaroudakis, D.; Yanarella, C.; Chiteri, K.; Dostalik, H. A.; Joshi, P.; Starr, D. C.; Vu, H.; Wimalanathan, K.; Lawrence-Dill, C. J.
10.1101/2021.04.25.441366 — bioinformatics — Posted on 2021-05-24
1060 Quantifying the Inhibitory Impact of Soluble Phenolics on Carbon Mineralization from Sphagnum-rich Peatlands
Cory, A.; Chanton, J.; Spencer, R.; Rich, V.; McCalley, C.; Wilson, R.; Scott R. Saleska, Patrick M. Crill, Gene W. Tyson, Ruth K. Varner, Matthew B. Sullivan, Steven Frolk,
10.1101/2021.05.24.445415 — ecology — Posted on 2021-05-24
1061 Knockdown of a novel ATPase domain of capsid protein inhibits genome packaging in potato leaf roll virus
Kumar, J.; Kumar, R. R.; Das, D. K.; Mohanty, A.; Rajani, K.; Kumari, N.; Kumar, V.; Kumar, S.; Ranjan, T.
10.1101/2021.05.24.445413 — molecular biology — Posted on 2021-05-24
1062 The Structure of ChAdOx1/AZD-1222 Reveals Interactions with CAR and PF4 with Implications for Vaccine-induced Immune Thrombotic Thrombocytopenia
Baker, A. T.; Boyd, R. J.; Sarkar, D.; Vant, J. W.; Teijeira-Crespo, A.; Waraich, K.; Truong, C. D.; Bates, E. A.; Wilson, E. A.; Chan, C. K.; Lipka-Lloyd, M.; Fromme, P.; Nagalo, M. B.; Heurich, M.; Williams, D.; Chiu, P.-L.; Rizkallah, P. J.; Parker, A. L.; Singharoy, A.; Borad, M. J.
10.1101/2021.05.19.444882 — molecular biology — Posted on 2021-05-24
1063 Genomic Mining and Physiological Characterization of new Halophilic Plant Growth Promoting Bacilli
Petrillo, C.; Castaldi, S.; Lanzilli, M.; Selci, M.; Cordone, A.; Giovannelli, D.; Isticato, R.
10.1101/2021.05.17.444429 — microbiology — Posted on 2021-05-24
1065 Mapping Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells
Shetty, A.; Bhosale, S. D.; Tripathi, S. K.; Buchacher, T.; Biradar, R.; Rasool, O.; Moulder, R.; Galande, S.; Lahesmaa, R.
10.1101/2021.05.12.443731 — immunology — Posted on 2021-05-24
1066 Spoken language comprehension activates the primary visual cortex
Seydell-Greenwald, A.; Wang, X.; Newport, E.; Bi, Y.; Striem-Amit, E.
10.1101/2020.12.02.408765 — neuroscience — Posted on 2021-05-24
1067 Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism
Frei, J. A.; Niescier, R. F.; Bridi, M. S.; Durens, M.; Nestor, J. E.; Kilander, M. B.; Yuan, X.; Dykxhoorn, D. M.; Nestor, M. W.; Huang, S.; Blatt, G. J.; Lin, Y.-C.
10.1101/2020.04.24.058438 — neuroscience — Posted on 2021-05-24
1068 Contributions of h- and Na+/K+ pump currents to the generation of episodic and continuous rhythmic activities
Sharples, S. A.; Vargas, A.; Lognon, A. P.; Young, L.; Cheng, N.; Shonak, A.; Cymbalyuk, G. S.; Whelan, P. J.
10.1101/2020.09.08.288266 — neuroscience — Posted on 2021-05-24
1070 Genetically engineered coral: A mixed-methods analysis of initial public opinion
Hobman, E.; Mankad, A.; Carter, L.; Ruttley, C.; Aditi Mankad, Lucy Carter, Chantale Ruttley,
10.1101/2021.05.24.445411 — synthetic biology — Posted on 2021-05-24
1073 Insights into substrate recognition and specificity for IgG by Endoglycosidase S2
Aytenfisu, A. H.; Deredge, D.; Klontz, E. H.; Du, J.; Sundberg, E.; MacKerell, A.
10.1101/2021.05.24.445403 — biophysics — Posted on 2021-05-24
1074 DeepLIIF: Deep Learning-Inferred Multiplex ImmunoFluorescence for IHC Quantification
Ghahremani, P.; Li, Y.; Kaufman, A.; Vanguri, R.; Greenwald, N.; Angelo, M.; Hollmann, T. J.; Nadeem, S.
10.1101/2021.05.01.442219 — bioinformatics — Posted on 2021-05-24
1076 Pathway analysis in metabolomics: pitfalls and best practice for the use of over-representation analysis
Wieder, C.; Frainay, C.; Poupin, N.; Rodriguez-Mier, P.; Vinson, F.; Cooke, J.; Lai, R. P.; Bundy, J. G.; Jourdan, F.; Ebbels, T.
10.1101/2021.05.24.445406 — bioinformatics — Posted on 2021-05-24
1077 ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair
Patil, P.; Russo, K. A.; McCune, J. T.; Pollins, A. C.; Cottom, M. A.; Dollinger, B. R.; Colazo, J. M.; Yu, F.; Martin, J. R.; Gupta, M. K.; Cardwell, N. L.; Davidson, J. M.; Thompson, C. M.; Barbul, A.; Hasty, A. M.; Guelcher, S. A.; Duvall, C. L.
10.1101/2021.05.21.445175 — bioengineering — Posted on 2021-05-24
1082 Mapping Brain-Behavior Space Relationships Along the Psychosis Spectrum
Ji, J. L.; Helmer, M.; Fonteneau, C.; Burt, J. B.; Tamayo, Z.; Demsar, J.; Adkinson, B.; Savic, A.; Preller, K.; Moujaes, F.; Vollenweider, F. X.; Martin, W.; Repovs, G.; Murray, J. D.; Anticevic, A.
10.1101/2020.09.15.267310 — neuroscience — Posted on 2021-05-24
1085 Natural variation in a short region of the Acidovorax citrulli type III-secreted effector AopW1 is associated with differences in cytotoxicity
JIMENEZ-GUERRERO, I.; SONAWANE, M.; ECKSHTAIN-LEVI, N.; DA SILVA, G. M.; PEREZ-MONTANO, F.; LEIBMAN-MARKUS, M.; NODA-GARCIA, L.; BAR, M.; Burdman, S.
10.1101/2021.05.24.445476 — plant biology — Posted on 2021-05-24
1088 Dimerization of SARS-CoV-2 nucleocapsid protein affects sensitivity of ELISA based diagnostics of COVID-19
Khan, W. H.; Khan, N.; Mishra, A.; Gupta, S.; Bansode, V.; Mehta, D.; Bhambure, R.; Rathore, A. S.
10.1101/2021.05.23.445305 — bioengineering — Posted on 2021-05-24
1090 Island-specific evolution of a sex-primed autosome in the planarian Schmidtea mediterranea
Guo, L.; Bloom, J. S.; Serrate, D. D.; David, E. B.; Schubert, O. T.; Kazuma, K.; Ho, K.; Wei, Y.; Leighton, D.; Boocock, J.; Vergara, T. L.; Riutort, M.; Alvarado, A. S.; Kruglyak, L.
10.1101/2021.05.24.445457 — genetics — Posted on 2021-05-24
1091 The RNA chaperone protein CspA stimulates translation during cold acclimation by promoting the progression of the ribosomes
Giuliodori, A. M.; Belardinelli, R.; Duval, M.; Garofalo, R.; Schenckbecher, E.; Hauryliuk, V.; Ennifar, E.; Marzi, S.
10.1101/2021.05.24.445485 — molecular biology — Posted on 2021-05-24
1092 Rab3a regulates melanin exocytosis induced by keratinocyte-conditioned medium
Cabaco, L. C.; Bento-Lopes, L.; Neto, M. V.; Ramalho, J. S.; Seabra, M. C.; Barral, D. C.
10.1101/2021.05.24.445450 — molecular biology — Posted on 2021-05-24
1096 HIV-1 Nef and CycK:CDK13 antagonize SERINC5 for optimal viral infectivity
Chai, Q.; Li, S.; Collins, M. K.; Li, R.; Ahmad, I.; Johnson, S. F.; Frabutt, D. A.; Yang, Z.; Shen, X.; Sun, L.; Hu, J.; Hultquist, J. F.; Peterlin, B. M.; Zheng, Y.-H.
10.1101/2021.05.24.445478 — microbiology — Posted on 2021-05-24
1097 Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
Hioe, C. E.; Li, G.; Liu, X.; Tsahouridis, O.; He, X.; Funaki, M.; Klingler, J.; Tang, A. F.; Feyznezhad, R.; Heindel, D. W.; Wang, X.-H.; Spencer, D. A.; Hu, G.; Satija, N.; Prevost, J.; Finzi, A.; Hessell, A.; Wang, S.; Lu, S.; Chen, B. K.; Zolla-Pazner, S.; Upadhyay, C.; Alvarez, R. A.; Su, L.
10.1101/2021.05.24.445493 — immunology — Posted on 2021-05-24
1098 Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
Chen, C.-W.; Guan, B.-J.; Alzahrani, M. R.; Gao, Z.; Gao, L.; Bracey, S.; Haataja, L.; Schaffer, A. E.; Lee, H.; Laframboise, T.; Bederman, I.; Arvan, P.; Mathews, C. E.; Gerling, I.; Kaestner, K. H.; Tirosh, B.; Engin, F.; Hatzoglou, M.
10.1101/2021.05.24.445193 — systems biology — Posted on 2021-05-24
1099 Reprogrammed tracrRNAs enable repurposing RNAs as crRNAs and detecting RNAs
Liu, Y.; Pinto, F.; Wan, X.; Peng, S.; Li, M.; Xie, Z.; French, C. E.; Wang, B.
10.1101/2021.05.24.445356 — synthetic biology — Posted on 2021-05-24
1104 Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.
Hossain, M. S.; Pathan, A. Q. M. S. U.; Islam, M. N.; Tonmoy, M. I. Q.; Rakib, M. I.; Munim, M. A.; Saha, O.; Fariha, A.; Al Reza, H.; Roy, M.; Bahadur, N. M.; Rahaman, M. M.
10.1101/2021.05.23.445341 — bioinformatics — Posted on 2021-05-24
1108 Severe Acute Respiratory Syndrome Coronavirus-2 genome sequence variations relate to morbidity and mortality in Coronavirus Disease-19
Mehta, P.; Sarkar, S.; Ghoshal, U.; Pandey, A.; Singh, R.; Singh, D.; Vishvkarma, R.; Ghoshal, U. C.; Maurya, R.; Pandey, R.; Ramachandran, R.; Bhadury, P.; Kundu, T. K.; Singh, R.
10.1101/2021.05.24.445374 — genomics — Posted on 2021-05-24
1109 Nucleocapsid mutation R203K/G204R increases the infectivity, fitness and virulence of SARS-CoV-2
Wu, H.; Xing, N.; Meng, K.; Fu, B.; Xue, W.; Dong, P.; Xiao, Y.; Liu, G.; Luo, H.; Zhu, W.; Lin, X.; Meng, G.; Zhu, Z.
10.1101/2021.05.24.445386 — evolutionary biology — Posted on 2021-05-24
1110 De novo mutation rates at the single-mutation resolution in a human HBB gene-region associated with adaptation and genetic disease
Melamed, D.; Nov, Y.; Malik, A.; Yakass, M. B.; Bolotin, E.; Shemer, R.; Hiadzi, E. K.; Skorecki, K. L.; Livnat, A.
10.1101/2021.05.24.443729 — evolutionary biology — Posted on 2021-05-24
1112 Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing
Crochemore, C.; Chica, C.; Garagnani, P.; Lattanzi, G.; Horvath, S.; Sarasin, A.; Franceschi, C.; Bacalini, M. G.; Ricchetti, M.
10.1101/2021.05.23.445308 — molecular biology — Posted on 2021-05-24
1113 Isolation of SARS-CoV-2 B.1.1.28.2 P2 variant and pathogenicity comparison with D614G variant in hamster model
Yadav, P.; Mohandas, S.; Sarkale, P.; Nyayanit, D.; Shete, A.; Sahay, R.; Potdar, V.; Baradkar, S.; Gupta, N.; Sapkal, G.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.05.24.445424 — microbiology — Posted on 2021-05-24
1114 A defined medium based on R2A for cultivation and exometabolite profiling of soil bacteria
de Raad, M.; Li, Y.; Andeer, P.; Kosina, S. M.; Saichek, N. R.; Golini, A.; Han, L. Z.; Wang, Y.; Bowen, B. P.; Chakraborty, R.; Northen, T. R.
10.1101/2021.05.23.445362 — microbiology — Posted on 2021-05-24
1116 Selection for cell yield does not reduce overflow metabolism in E. coli
Rabbers, I.; Gottstein, W.; Feist, A.; Teusink, B.; Bruggeman, F.; Bachmann, H.
10.1101/2021.05.24.445453 — microbiology — Posted on 2021-05-24
1120 Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative
Malladi, S. K.; Patel, U. R.; Rajmani, R. S.; Singh, R.; Pandey, S.; Kumar, S.; Khaleeq, S.; Gayathri, S.; Chakraborty, D.; Kalita, P.; Pramanick, I.; Agarwal, N.; Reddy, P.; Girish, N.; Upadhyaya, A.; Khan, M. S.; Kanjo, K.; Bhat, M.; Mani, S.; Bhattacharyya, S.; Siddiqui, S.; Tyagi, A.; Jha, S.; Pandey, R.; Tripathi, S.; Dutta, S.; Ringe, R. P.; Varadarajan, R.
10.1101/2021.01.13.426626 — microbiology — Posted on 2021-05-24
1121 Nfkbid is required for immunity and antibody responses to Toxoplasma gondii
Souza, S. P.; Splitt, S. D.; Alvarez, J. A.; Sanchez-Arcila, J. C.; Wilson, J.; Wizzard, S.; Luo, Z.; Baumgarth, N.; Jensen, K.
10.1101/2020.06.26.174151 — immunology — Posted on 2021-05-24
1124 Tau in the brain interstitial fluid is fragmented and seeding-competent
Barini, E.; Plotzky, G.; Mordashova, Y.; Hoppe, J.; Rodriguez-Correa, E.; Julier, S.; LePrieult, F.; Mairhofer, I.; Mezler, M.; Biesinger, S.; Cik, M.; Meinhardt, M. W.; Ercan-Herbst, E.; Ehrnhoefer, D.; Striebinger, A.; Bodie, K.; Klein, C.; Gasparini, L.; Schlegel, K.
10.1101/2020.07.15.205724 — neuroscience — Posted on 2021-05-24
1126 Evidence for Deleterious Original Antigenic Sin in SARS-CoV-2 Immune Response
Sen, S. R.; Sanders, E. C.; Santos, A. M.; Bhuvan, K.; Tang, D. Y.; Gelston, A. A.; Miller, B. M.; Ricks-Oddie, J. L.; Weiss, G. A.
10.1101/2021.05.21.445201 — immunology — Posted on 2021-05-24
1127 Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Salzer, R.; Clark, J. J.; Vaysburd, M.; Chang, V. T.; Albecka, A.; Kiss, L.; Sharma, P.; Gonzalez Llamazares, A.; Kipar, A.; Hiscox, J. A.; Owen, A.; Aricescu, A. R.; Stewart, J. P.; James, L. C.; Lowe, J.
10.1101/2021.05.18.444622 — immunology — Posted on 2021-05-24
1128 Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates
Corbett, K. S.; Werner, A.; O'Connell, S.; Gagne, M.; Lai, L.; Moliva, J.; Flynn, B.; Choi, A.; Koch, M.; Foulds, K. E.; Andrew, S.; Flebbe, D.; Lamb, E.; Nurmukhambetova, S. T.; Provost, S.; Bock, K. W.; Minai, M.; Nagata, B. M.; Van Ry, A.; Flinchbaugh, Z.; Johnston, T. S.; Bayat Mokhtari, E.; Mudvari, P.; Henry, A. R.; Laboune, F.; Chang, B.; Porto, M.; Wear, J.; Alvarado, G. S.; Boyoglu-Barnum, S.; Todd, J.-P.; Bart, B.; Cook, A.; Dodson, A.; Pessaint, L.; Steingrebe, K.; Elbashir, S.; Andersen, H.; Wu, K.; Edwards, D. K.; Kar, S.; Lewis, M. G.; Boritz, E.; Moore, I.; Carfi, A.; Suthar, M.
10.1101/2021.05.21.445189 — immunology — Posted on 2021-05-24
1133 Cryo-ET reveals two major tubulin-based cytoskeleton structures in Toxoplasma gondii
Sun, S. Y.; Segev-Zarko, L.-a.; Chen, M.; Pintilie, G. D.; Schmid, M. F.; Ludtke, S. J.; Boothroyd, J. C.; Chiu, W.
10.1101/2021.05.23.445366 — molecular biology — Posted on 2021-05-24
1137 P53 is a direct regulator of the immune co-stimulatory molecule CD80
Alibo, E.; Mollaoglu, G.; Dhainaut, M.; Zhao, R.; Rose, S.; Baccarini, A.; Parsons, R.; Brown, B. D.
10.1101/2021.05.24.445214 — immunology — Posted on 2021-05-24
1141 Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria
Balakrishnan, R.; Mori, M.; Segota, I.; Zhang, Z.; Aebersold, R.; Ludwig, C.; Hwa, T.
10.1101/2021.05.24.445329 — systems biology — Posted on 2021-05-24
1143 Generative neural networks separate common and specific transcriptional responses
Lee, A. J.; Mould, D. L.; Crawford, J.; Hu, D.; Powers, R. K.; Doing, G.; Costello, J. C.; Hogan, D. A.; Greene, C. S.
10.1101/2021.05.24.445440 — bioinformatics — Posted on 2021-05-24
1145 Automatic instance segmentation of mitochondria in electron microscopy data
Nightingale, L.; de Folter, J.; Spiers, H.; Strange, A.; Collinson, L. M.; Jones, M. L.
10.1101/2021.05.24.444785 — bioinformatics — Posted on 2021-05-24
1146 Kinetic Monitoring Of Neuronal Stress Response To Proteostasis Dysfunction
Santiago-Lopez, A. J.; Berglund, K.; Gross, R. E.; Gutekunst, C.-A. N.
10.1101/2021.05.24.445437 — cell biology — Posted on 2021-05-24
1148 Protein detection in blood with single-molecule imaging
Mao, C.-P.; Wang, S.-C.; Su, Y.-P.; Tseng, S.-H.; He, L.; Wu, A.; Roden, R.; Xiao, J.; Hung, C.-F.
10.1101/2021.05.19.444873 — biophysics — Posted on 2021-05-24
1149 Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation
Ball, S. R.; Adamson, J. S.; Sullivan, M. A.; Zimmermann, M. R.; Lo, V.; Sanz-Hernandez, M.; Jiang, F.; Kwan, A. H.; Werry, E. L.; Knowles, T. P.; Kassiou, M.; Meisl, G.; Todd, M. H.; Rutledge, P. R.; Sunde, M.
10.1101/2020.11.16.384248 — biophysics — Posted on 2021-05-24
1151 Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8+ T cell responses in HLA-A transgenic mice
Jin, X.; Ding, Y.; Sun, S.; Wang, X.; Zhou, Z.; Liu, X.; Li, M.; Chen, X.; Shen, A.; Wu, Y.; Liu, B.; Zhang, J.; Li, J.; Yang, Y.; Qiu, H.; Shen, C.; He, Y.; Zhao, G.
10.1101/2021.04.01.438020 — immunology — Posted on 2021-05-24
1153 Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2
Fischhoff, I. R.; Castellanos, A. A.; Rodrigues, J. P. G. L. M.; Varsani, A.; Han, B. A.
10.1101/2021.02.18.431844 — ecology — Posted on 2021-05-24
1155 RNase E endonuclease activity and its inhibition by pseudoridine
Islam, M. S.; Bandyra, K. J.; Chao, Y.; Vogel, J.; Luisi, B. F.
10.1101/2021.05.23.445298 — biochemistry — Posted on 2021-05-24
1156 TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction
Galao, R. P.; Wilson, H.; Schierhorn, K. L.; Debeljak, F.; Bodmer, B. S.; Goldhill, D.; Hoenen, T.; Wilson, S. J.; Swanson, C. M.; Neil, S.
10.1101/2021.05.23.445113 — microbiology — Posted on 2021-05-24
1161 A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration
Castelli, L. M.; Sanchez-Martinez, A.; Lin, Y.-H.; Kumar Upadhyay, S.; Higginbottom, A.; Cooper-Knock, J.; Gul, A.; Walton, A.; Montmasson, C.; Cohen, R.; Bauer, C. S.; De Vos, K. J.; Azzouz, M.; Shaw, P. J.; Dominguez, C.; Ferraiuolo, L.; Whitworth, A. J.; Hautbergue, G. M.
10.1101/2021.05.23.445325 — molecular biology — Posted on 2021-05-24
1162 A multi-scale in silico mouse model for insulin resistance and humanoid type 2 diabetes
Simonsson, C.; Lövfors, W.; Bergqvist, N.; Nyman, E.; Gennemark, P.; Stenkula, K. G.; Cedersund, G.
10.1101/2021.05.19.443124 — systems biology — Posted on 2021-05-24
1163 N-glycosylation of CD24 mediates cell motility but inhibits cell proliferation in colorectal cancer
Hakami, Z.; Raposo, T. P.; Alsulaiman, A.; Dalleywater, W.; Otifi, H.; Horobin, C.; Garrie, K.; Ilyas, M.
10.1101/2021.05.02.442315 — cancer biology — Posted on 2021-05-24
1164 Bioptim, a Python framework for Musculoskeletal Optimal Control in Biomechanics
Michaud, B.; Bailly, F.; Charbonneau, E.; Ceglia, A.; Sanchez, L.; Begon, M.
10.1101/2021.02.27.432868 — bioengineering — Posted on 2021-05-24
1165 Multi-omics approach to identify bacterial polyynes and unveil their antifungal mechanism against Candida albicans
Lin, C.-C.; Hoo, S. Y.; Lin, C.; Huang, K.-F.; Ho, Y.-N.; Sun, C.-H.; Lee, H.-J.; Chen, P.-Y.; Shu, L.-J.; Wang, B.-W.; Hsu, W.-C.; Yang, Y.-L.
10.1101/2021.03.30.437786 — microbiology — Posted on 2021-05-24
1167 A genetic switch for male UV-iridescence in an incipient species pair of sulphur butterflies
Ficarrotta, V.; Hanly, J. J.; Loh, L. S.; Francescutti, C. M.; Ren, A.; Tunström, K.; Wheat, C. W.; Porter, A. H.; Counterman, B. A.; Martin, A.
10.1101/2021.05.21.445125 — evolutionary biology — Posted on 2021-05-23
1171 Plant trait heterosis is quantitatively associated with expression heterosis of plastid ribosomal proteins
Birdseye, D.; De Boer, L.; Shen, Z.; Bai, H.; Zhou, P.; Schmelz, E. A.; Springer, N. M.; Briggs, S.
10.1101/2021.02.16.431485 — plant biology — Posted on 2021-05-23
1172 Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait
Ferreira, I.; de Oliveira, R. M.; Carvalho, A. S.; Teshima, A.; Beck, H. C.; Matthiesen, R.; Silva, B. C.; Macedo, M. P.
10.1101/2021.02.19.431856 — pathology — Posted on 2021-05-23
1173 Profiles of expressed mutations in single cells reveal subclonal expansion patterns and therapeutic impact of intratumor heterogeneity
Rashidi Mehrabadi, F.; Marie, K. L.; Perez-Guijarro, E.; Malikic, S.; Sadeqi Azer, E.; Yang, H. H.; Kizilkale, C.; Gruen, C.; Robinson, W.; Liu, H.; Kelly, M. C.; Marcelus, C.; Burkett, S.; Buluc, A.; Ergun, F.; Lee, M. P.; Merlino, G.; Day, C.-P.; Sahinalp, S. C.
10.1101/2021.03.26.437185 — bioinformatics — Posted on 2021-05-23
1179 In vivo direct imaging of neuronal activity at high temporo-spatial resolution
Toi, P. T.; Jang, H. J.; Min, K.; Kim, S.-P.; Lee, S.-K.; Lee, J.; Kwag, J.; Park, J.-Y.
10.1101/2021.05.21.444581 — neuroscience — Posted on 2021-05-23
1180 Medial prefrontal activity at encoding determines enhanced recognition of threatening faces after 1.5 years
Liu, X.; Zhou, X.; Zeng, Y.; Li, J.; Zhao, W.; Xu, L.; Zheng, X.; Fu, M.; Yao, S.; Cannistraci, C. V.; Kendrick, K. M.; Becker, B.
10.1101/2020.08.25.266353 — neuroscience — Posted on 2021-05-23
1181 Partial reprogramming restores youthful gene expression through transient suppression of cell identity
Roux, A.; Zhang, C.; Paw, J.; Zavala-Solorio, J.; Vijay, T.; Kolumam, G.; Kenyon, C.; Kimmel, J. C.
10.1101/2021.05.21.444556 — systems biology — Posted on 2021-05-23
1184 The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival
Shaw, R. J.; Brun, S. N.; Lumibao, J.; Limpert, A.; Ren, H.; Ianniciello, A.; Cosford, N.; Tiriac, H.; Downes, M.; Evans, R.; Engle, D. D.
10.1101/2021.05.15.444304 — cancer biology — Posted on 2021-05-23
1187 Positive Selection and Heat-Response Transcriptomes Reveal Adaptive Features of the Arabidopsis Desert Relative, Anastatica hierochuntica
Eshel, G.; Duppen, N.; Wang, G.; Oh, D.-H.; Kazachkova, Y.; Herzyk, P.; Amtmann, A.; Gordon, M.; Chalifa-Caspi, V.; Oscar, M. A.; Bar-David, S.; Marshall-Colon, A.; Dassanayake, M.; Barak, S.
10.1101/2021.05.23.445339 — plant biology — Posted on 2021-05-23
1189 Anchored and labile pools of Calcineurin are enabled by a disordered AKAP scaffold
Watson, M.; Almeida, T.; Ray, A.; Hanack, C.; Elston, R.; Btesh, J.; McNaughton, P.; Stott, K.
10.1101/2021.05.23.445342 — biophysics — Posted on 2021-05-23
1193 Serine catabolism generates NADPH to support hepatic lipogenesis
Zhang, Z.; TeSlaa, T.; Xu, X.; Zeng, X.; Yang, L.; Xing, G.; Tesz, G.; Clasquin, M.; Rabinowitz, J.
10.1101/2021.05.22.445276 — biochemistry — Posted on 2021-05-23
1194 Genetic Dissection of the RNA Polymerase II Transcription Cycle
Chou, S.-P.; Alexander, A. K.; Rice, E. J.; Choate, L. A.; Cohen, P. E.; Danko, C. G.
10.1101/2021.05.23.445279 — genomics — Posted on 2021-05-23
1199 Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Reint, G.; Li, Z.; Labun, K.; Keskitalo, S.; Soppa, I.; Mamia, K.; Tolo, E.; Szymanska, M.; Meza-Zepeda, L. A.; Lorenz, S.; Cieslar-Pobuda, A.; Hu, X.; Bordin, D. L.; Staerk, J.; Valen, E.; Schmierer, B.; Varjosalo, M.; Taipale, J.; Haapaniemi, E.
10.1101/2021.05.23.445089 — molecular biology — Posted on 2021-05-23
1201 A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration
Castelli, L. M.; Sanchez-Martinez, A.; Lin, Y.-H.; Kumar Upadhyay, S.; Higginbottom, A.; Cooper-Knock, J.; Gul, A.; Walton, A.; Montmasson, C.; Cohen, R.; Bauer, C. S.; De Vos, K. J.; Azzouz, M.; Shaw, P. J.; Dominguez, C.; Ferraiuolo, L.; Whitworth, A. J.; Hautbergue, G. M.
10.1101/2021.05.23.445325 — molecular biology — Posted on 2021-05-23
1202 Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse
Nomura, H.; Wada, N.; Takahashi, H.; Kase, Y.; Yamagami, J.; Egami, S.; Iriki, H.; Mukai, M.; Kamata, A.; Ito, H.; Fujii, H.; Ishikura, T.; Koseki, H.; Watanabe, T.; Yamada, T.; Ohara, O.; Koyasu, S.; Amagai, M.
10.1101/2021.05.23.445300 — immunology — Posted on 2021-05-23
1203 DNA Methyltransferase 1 and 3a Expression in the Frontal Cortex Regulates Palatable Food Consumption
Manjegowda, M. C.; Joy-Gaba, J.; Wengert, E. R.; Saga, A. U.; Warthen, D. M.; Nemc, A.; Gaykema, R. P.; Patel, M. K.; Sheffield, N. C.; Scott, M. M.
10.1101/2021.05.23.445176 — neuroscience — Posted on 2021-05-23
1205 Alpha oscillatory activity causally linked to working memory retention: insights from online phase-locking closed-loop transcranial alternating current stimulation (tACS)
Chen, X.; Ma, R.; Zhang, W.; Wu, Q.; Yimiti, A.; Xia, X.; Cui, J.; Zeng, G. Q.; Bu, J.; Chen, Q.; Yu, N. X.; Wang, S.; Deng, Z.-D.; Sack, A. T.; Laughlin, M. M.; Zhang, X.
10.1101/2021.05.23.445322 — neuroscience — Posted on 2021-05-23
1206 A Spatiotemporal Map of Reading Aloud
Woolnough, O.; Donos, C.; Curtis, A.; Rollo, P. S.; Roccaforte, Z. J.; Dehaene, S.; Fischer-Baum, S.; Tandon, N.
10.1101/2021.05.23.445307 — neuroscience — Posted on 2021-05-23
1207 3D-MASNet: 3D Mixed-scale Asymmetric Convolutional Segmentation Network for 6-month-old Infant Brain MR Images
Zeng, Z.; Zhao, T.; Sun, L.; Zhang, Y.; Xia, M.; Liao, X.; Zhang, J.; Shen, D.; Wang, L.; He, Y.
10.1101/2021.05.23.445294 — neuroscience — Posted on 2021-05-23
1210 Hippocampal TRPV1 channels in the modulation of contextual fear conditioning
Iglesias, L. P.; Fernandes, H. d. B.; de Miranda, A. S.; Sorgi, C. A.; Moreira, F. d. A.
10.1101/2021.05.23.445340 — pharmacology and toxicology — Posted on 2021-05-23
1212 MLC Seq: De novo sequencing of full-length tRNA isoforms by mass ladder complementation
Yuan, X.; Su, Y.; Zhang, X.; Turkel, S. J.; Shi, S.; Wang, X.; Choi, E.-J.; Wu, W.; Liu, H.; Viner, R.; Russo, J. J.; Li, W.; Bao, X.; Chen, Q.; Zhang, S.
10.1101/2021.05.22.445286 — biochemistry — Posted on 2021-05-23
1213 Label-free three-dimensional analyses of live cells with deep-learning-based segmentation exploiting refractive index distributions
Choi, J.; Kim, H.-J.; Sim, G.; Lee, S.; Park, W. S.; Park, J. H.; Kang, H.-Y.; Lee, M.; Heo, W. D.; Choo, J.; Min, H.; Park, Y.
10.1101/2021.05.23.445351 — cell biology — Posted on 2021-05-23
1217 Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle
Tsan, Y.-C.; Zhao, Y.-T.; DePalma, S. J.; Capilnasiu, A.; Wu, Y.-W.; Elder, B.; Panse, I.; Friedline, S.; O'Leary, T. S.; Wubshet, N.; Ho, K. K. Y.; Previs, M. J.; Nordsletten, D.; Baker, B. M.; Isom, L. L.; Liu, A. P.; Helms, A. S.
10.1101/2021.05.23.445330 — cell biology — Posted on 2021-05-23
1219 The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Nirmal, A. J.; Maliga, Z.; Vallius, T.; Quattrochi, B.; Chen, A. A.; Jacobson, C. A.; Pelletier, R. J.; Yapp, C.; Arias-Camison, R.; Chen, Y.-A.; Lian, C. G.; Murphy, G. F.; Santagata, S.; Sorger, P. K.
10.1101/2021.05.23.445310 — cancer biology — Posted on 2021-05-23
1222 Dynamic FRET-FLIM based screens of signal transduction pathways: a feasibility study
Harkes, R.; Kukk, O.; Mukherjee, S.; Klarenbeek, J.; van den Broek, B.; Jalink, K.
10.1101/2021.05.23.445328 — cell biology — Posted on 2021-05-23
1226 delilah, prospero and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors
Avetisyan, A.; Glatt, Y.; Cohen, M.; Timerman, Y.; Aspis, N.; Nachman, A.; Halachmi, N.; Preger-Ben Noon, E.; Salzberg, A.
10.1101/2021.04.07.438778 — developmental biology — Posted on 2021-05-23
1228 Mouse frontal cortex mediates additive multisensory decisions
Coen, P.; Sit, T. P.; Wells, M. J.; Carandini, M.; Harris, K. D.
10.1101/2021.04.26.441250 — neuroscience — Posted on 2021-05-23
1230 AxonDeep: Automated Optic Nerve Axon Segmentation in Mice with Deep Learning.
Deng, W.; Hedberg-Buenz, A.; Soukup, D. A.; Taghizadeh, S.; Anderson, M. G.; Garvin, M. K.
10.1101/2021.05.21.445196 — bioengineering — Posted on 2021-05-23
1231 Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
Bhattacharya, S.; Wang, S.; Reddy, D.; Shen, S.; Zhang, Y.; Zhang, N.; Li, H.; Washburn, M.; Florens, L.; Shi, Y.; Li, F.; Workman, J.
10.1101/2021.05.22.445248 — biochemistry — Posted on 2021-05-23
1232 Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa
Atkinson, E. G.; Dalvie, S.; Pichkar, Y.; Kalungi, A.; Majara, L.; Stevenson, A.; Abebe, T.; Akena, D.; Alemayehu, M.; Ashaba, F. K.; Atwoli, L.; Baker, M.; Chibnik, L. B.; Creanza, N.; Daly, M. J.; Fekadu, A.; Gelaye, B.; Gichuru, S.; Injera, W. E.; James, R.; Kariuki, S. M.; Kigen, G.; Koen, N.; Koenen, K. C.; Koenig, Z.; Kwobah, E.; Kyebuzibwa, J.; Musinguzi, H.; Mwema, R. M.; Neale, B. M.; Newman, C. P.; Newton, C. R. J. C.; Ongeri, L.; Ramachandran, S.; Ramesar, R.; Shiferaw, W.; Stein, D. J.; Stroud, R. E.; Teferra, S.; Zingela, Z.; Martin, A. R.; NeuroGAP-Psychosis Study Team,
10.1101/2021.05.19.444732 — genomics — Posted on 2021-05-23
1237 A single motor neuron determines the rhythm of early motor behaviour in Ciona
Akahoshi, T.; Oonuma, K.; Murakami, M.; Horie, T.; Kusakabe, T. G.; Oka, K.; Hotta, K.
10.1101/2021.03.10.434256 — neuroscience — Posted on 2021-05-23
1238 AMP-Kinase mediates regulation of glomerular volume and podocyte survival
Banu, K.; Lin, Q.; Basgen, J. M.; Planoutene, M.; Wei, C.; Reghuvaran, A. C.; Garzon, F.; Garcia, A.; Chun, N.; Cumpelik, A.; Shi, H.; Santaneusio, A.; Zhang, W.; Das, B.; Salem, F.; Li, L.; Cantley, L. G.; Ishibe, S.; Kaufman, L.; Lemley, K. V.; Ni, Z.; He, J. C.; Murphy, B.; Menon, M. C.
10.1101/2021.05.21.445180 — systems biology — Posted on 2021-05-23
1239 Partial reprogramming restores youthful gene expression through transient suppression of cell identity
Roux, A.; Zhang, C.; Paw, J.; Solorio, J.-Z.; Vijay, T.; Kolumam, G.; Kenyon, C.; Kimmel, J. C.
10.1101/2021.05.21.444556 — systems biology — Posted on 2021-05-23
1240 Non-coding NFKBIZ 3' UTR mutations promote cell growth and resistance to targeted therapies in diffuse large B-cell lymphoma
Arthur, S. E.; Gao, J.; Healy, S.; Rushton, C. K.; Thomas, N.; Hilton, L. K.; Dreval, K.; Tang, J.; Alcaide, M.; Cojocaru, R.; Mottok, A.; Telenius, A.; Unrau, P.; Wilson, W. H.; Staudt, L. M.; Scott, D. W.; Hodson, D. J.; Steidl, C.; Morin, R. D.
10.1101/2021.05.22.445261 — cancer biology — Posted on 2021-05-23
1241 Vcflib and tools for processing the VCF variant call format
Garrison, E.; Kronenberg, Z. N.; Dawson, E. T.; Pedersen, B. S.; Prins, P.
10.1101/2021.05.21.445151 — bioinformatics — Posted on 2021-05-23
1242 Comparison of Resources and Methods to infer Cell-Cell Communication from Single-cell RNA Data
Dimitrov, D.; Türei, D.; Boys, C.; Nagai, J. S.; Ramirez Flores, R. O.; Kim, H.; Szalai, B.; Costa, I. G.; Dugourd, A.; Valdeolivas, A.; Saez-Rodriguez, J.
10.1101/2021.05.21.445160 — bioinformatics — Posted on 2021-05-23
1243 DecoPath: A web application for decoding pathway enrichment analysis
Mubeen, S.; Bharadhwaj, V. S.; Gadiya, Y.; Hofmann-Apitius, M.; Kodamullil, A. T.; Domingo-Fernandez, D.
10.1101/2021.05.22.445243 — bioinformatics — Posted on 2021-05-23
1246 recount3: summaries and queries for large-scale RNA-seq expression and splicing
Wilks, C.; Zheng, S. C.; Chen, F. Y.; Charles, R.; Solomon, B.; Ling, J. P.; Imada, E. L.; Zhang, D.; Joseph, L.; Leek, J. T.; Jaffe, A. E.; Nellore, A.; Collado-Torres, L.; Hansen, K. D.; Langmead, B.
10.1101/2021.05.21.445138 — genomics — Posted on 2021-05-23
1252 Virus-Dependent Immune Conditioning of Tissue Microenvironments
Jiang, S.; Chan, C. N.; Rovira-Clave, X.; Chen, H.; Bai, Y.; Zhu, B.; McCaffrey, E.; Greenwald, N. F.; Liu, C.; Barlow, G. L.; Weirather, J. L.; Busman-Sahay, K.; Nekorchuk, M.; Terry, M.; Younger, S.; Oliveria, J. P.; Bosse, M.; Demeter, J.; Philips, D.; Mukherjee, N.; Golstev, Y.; McIlwain, D. R.; Angelo, M.; Estes, J. D.; Nolan, G. P.
10.1101/2021.05.21.444548 — immunology — Posted on 2021-05-23
1257 Molecular architecture determines brain delivery of a transferrin-receptor targeted lysosomal enzyme
Arguello, A.; Mahon, C. S.; Calvert, M. E. K.; Chan, D.; Dugas, J. C.; Pizzo, M. E.; Thomsen, E. R.; Chau, R.; Damo, L. A.; Duque, J.; Earr, T.; Fang, M.; Giese, T.; Kim, D. J.; Liang, N.; Lopez, I. A.; Nguyen, H. N.; Solanoy, H.; Tsogtbaatar, B.; Ullman, J. C.; Wang, J.; Dennis, M. S.; Diaz, D.; Gunasekaran, K.; Henne, K. R.; Lewcock, J. W.; Sanchez, P. E.; Troyer, M. D.; Harris, J. M.; Scearce-Levie, K.; Shan, L.; Watts, R. J.; Thorne, R. G.; Henry, A. G.; Kariolis, M. S.
10.1101/2021.05.21.445035 — neuroscience — Posted on 2021-05-23
1260 Tools for accurate post hoc determination of marker location within whole-brain microscopy images
Tyson, A. L.; Velez-Fort, M.; Rousseau, C. V.; Cossell, L.; Tsitoura, C.; Obenhaus, H. A.; Claudi, F.; Lenzi, S. C.; Branco, T.; Margrie, T. W.
10.1101/2021.05.21.445133 — neuroscience — Posted on 2021-05-23
1265 Rapamycin induced hyperglycemia is associated with exacerbated age-related osteoarthritis
Minton, D. M.; Elliehausen, C. J.; Javors, M. A. M.; Santangelo, K. S.; Konopka, A. R.
10.1101/2021.05.21.445179 — physiology — Posted on 2021-05-23
1266 Transcriptional and Functional Activity of Canine Hemangiosarcoma to Support Hematopoiesis Demonstrate Bone Marrow Nurse Cell Ontogeny
Kim, J. H.; Schulte, A. J.; Sarver, A. L.; Angelos, M. G.; Frantz, A. M.; Foster, C. L.; O'Brien, T. D.; Cornax, I.; O'Sullivan, M. G.; Cheng, N.; Lewellen, M.; Oseth, L.; Kumar, S.; Bullman, S.; Pedamallu, C. S.; Goyal, S. M.; Meyerson, M.; Lund, T. C.; Alfoldi, J.; Lindblad-Toh, K.; Breen, M.; Dickerson, E. B.; Kaufman, D. S.; Modiano, J. F.
10.1101/2021.05.21.445198 — cancer biology — Posted on 2021-05-23
1267 Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment
Huang, Y.; Garcia Garcia, C. J.; Lin, D.; Nguyen, N. D.; Fujimoto, T. N.; Zhao, J.; Lee, J. J.; Bernard, V.; Yu, M.; Delahoussaye, A. M.; Phan, J. L.; Deorukhkar, A.; Molkentine, J. M.; Fuentes, N. R.; Turner, M. C.; Saur, D.; Maitra, A.; Taniguchi, C. M.
10.1101/2021.05.21.445190 — cancer biology — Posted on 2021-05-23
1268 A proteomics sample metadata representation for multiomics integration, and big data analysis.
Dai, C.; Fullgrabe, A.; Pfeuffer, J.; Solovyeva, E.; Deng, J.; Moreno, P.; Kamatchinathan, S.; Jaiswal Kundu, D.; George, N.; Fexova, S.; Gruning, B.; Foll, M. C.; Griss, J.; Vaudel, M.; Audain, E.; Locard-Paulet, M.; Turewicz, M.; Eisenacher, M.; Uszkoreit, J.; Van Den Bossche, T.; Schwammle, V.; Webel, H.; Schulze, S.; Bouyssie, D.; Jayaram, S.; Kumar Duggineni, V.; Samaras, P.; Wilhelm, M.; Choi, M.; Wang, M.; Kohlbacher, O.; Brazma, A.; Papatheodorou, I.; Bandeira, N.; W. Deutsch, E.; Vizcaino, J. A.; Bai, M.; Levitsky, L.; Sachsenberg, T.; Perez-Riverol, Y.
10.1101/2021.05.21.445143 — bioinformatics — Posted on 2021-05-23
1272 Fast processing of environmental DNA metabarcoding sequence data using convolutional neural networks
Flück, B.; Mathon, L.; Manel, S.; Valentini, A.; Dejean, T.; Albouy, C.; Mouillot, D.; Thuiller, W.; Murienne, J.; Brosse, S.; Pellissier, L.
10.1101/2021.05.22.445213 — bioinformatics — Posted on 2021-05-23
1277 ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair
Patil, P.; Russo, K. A.; McCune, J. T.; Pollins, A. C.; Cottom, M. A.; Dollinger, B. R.; Colazo, J. M.; Yu, F.; Martin, J. R.; Gupta, M. K.; Cardwell, N. L.; Davidson, J. M.; Thompson, C. M.; Barbul, A.; Hasty, A. M.; Guelcher, S. A.; Duvall, C. L.
10.1101/2021.05.21.445175 — bioengineering — Posted on 2021-05-23
1278 Duplex-Repair enables highly accurate sequencing, despite DNA damage
Xiong, K.; Shea, D.; Rhoades, J.; Blewett, T.; Liu, R.; Bae, J.; Nguyen, E.; Makrigiorgos, M.; Golub, T.; Adalsteinsson, V.
10.1101/2021.05.21.445162 — genomics — Posted on 2021-05-23
1279 Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sexchromosome encoded genes
Köferle, A.; Schlattl, A.; Hörmann, A.; Spreitzer, F.; Popa, A. M.; Thatikonda, V.; Puchner, T.; Oberndorfer, S.; Wieshofer, C.; Corcokovic, M.; Reiser, C.; Wöhrle, S.; Popow, J.; Pearson, M.; Mair, B.; Neumüller, R. A.
10.1101/2021.05.21.445116 — genomics — Posted on 2021-05-23
1282 Leveraging a founder population to identify novel rare-population genetic determinants of lipidome
Montasser, M. E.; Aslibekyan, S.; Srinivasasainagendra, V.; Tiwari, H. K.; Patki, A.; Bagheri, M.; Perry, J. A.; Ryan, K. A.; Arnett, D. K.; Beitelshees, A. L.; Irvin, M. R.; O'Connell, J. R.
10.1101/2021.05.21.445208 — genetics — Posted on 2021-05-23
1287 Intrapopulation adaptive variance supports selective breeding in a reef-building coral
Drury, C.; Bean, N.; Harris, C.; Hancock, J.; Huckeba, J.; H, C. M.; Roach, T.; Quinn, R.; Gates, R. D.
10.1101/2021.05.21.445206 — ecology — Posted on 2021-05-23
1290 Gains of 12p13.31 delay WNT-mediated initiation of hPSC differentiation and promote residual pluripotency in a cell cycle dependent manner
Keller, A.; Lei, Y.; Krivec, N.; Couvreu De Deckersberg, E.; Dziedzicka, D.; Markouli, C.; Sermon, K. D.; Geens, M.; Spits, C.
10.1101/2021.05.22.445238 — cell biology — Posted on 2021-05-23
1291 APC/CFZR-1 Controls ZYG-1 Levels to Regulate Centrosome Assembly
Medley, J. C.; DiPanni, J. R.; Schira, L.; Shaffou, B.; Sebou, B.; SONG, M. H.
10.1101/2020.08.12.248658 — cell biology — Posted on 2021-05-23
1296 Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation
Joyner, C. J.; Ley, A.; Nguyen, D.; Ali, M.; Corrado, A.; Tipton, C.; Scharer, C.; Mi, T.; Woodruff, M. C.; Hom, J.; Boss, J. M.; Duan, M.; Gibson, G.; Roberts, D.; Andrews, J.; Lonial, S.; Sanz, I.; Lee, F. E.-H.
10.1101/2021.05.22.445269 — immunology — Posted on 2021-05-23
1298 Coordinated regulation of CB1 cannabinoid receptors and anandamide metabolism stabilize network activity during homeostatic scaling down
Ye, M.; Monroe, S. K.; Gay, S. M.; Armstrong, M. L.; Youngstrom, D. E.; Urbina, F. L.; Gupton, S. L.; Reisdorph, N.; Diering, G. H.
10.1101/2021.05.21.445170 — neuroscience — Posted on 2021-05-23
1299 Met is required for oligodendrocyte progenitor cell migration in Danio rerio
Ali, M. F.; Latimer, A. J.; Wang, Y.; Hogenmiller, L.; Fontenas, L.; Isabella, A. J.; Moens, C. B.; Yu, G.; Kucenas, S.
10.1101/2021.05.21.445204 — neuroscience — Posted on 2021-05-23
1301 In vivo direct imaging of neuronal activity at high temporo-spatial resolution
Toi, P. T.; Jang, H. J.; Min, K.; Kim, S.-P.; Lee, S.-K.; Lee, J.; Kwag, J.; Park, J.-Y.
10.1101/2021.05.21.444581 — neuroscience — Posted on 2021-05-23
1303 Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human
Escobar Sanabria, D.; Aman, J. E.; Zapata Amaya, V.; Johnson, L. A.; Farooqi, H.; Wang, J.; Hill, M.; Patriat, R.; Sovell-Brown, K.; Molnar, G. F.; Darrow, D.; McGovern, R.; Cooper, S. E.; Harel, N.; MacKinnon, C. D.; Park, M. C.; Vitek, J. L.
10.1101/2021.05.22.445251 — neuroscience — Posted on 2021-05-23
1306 Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells
Zhu, I.; Liu, R.; Hyrenius-Wittsten, A.; Piraner, D. I.; Alavi, J.; Israni, D. V.; Khalil, A. S.; Roybal, K. T.
10.1101/2021.05.21.445218 — synthetic biology — Posted on 2021-05-23
1307 A barley gene cluster for the biosynthesis of diterpenoid phytoalexins
Liu, Y.; Balcke, G. U.; Porzel, A.; Mahdi, L.; Scherr-Henning, A.; Bathe, U.; Zuccaro, A.; Tissier, A. F.
10.1101/2021.05.21.445084 — plant biology — Posted on 2021-05-22
1317 Application of transposon-insertion sequencing to determine gene essentiality in the acetogen Clostridium autoethanogenum
Woods, C.; Humphreys, C. M.; Tomi-Andrino, C.; Henstra, A. M.; Köpke, M.; Simpson, S. D.; Winzer, K.; Minton, N. P.
10.1101/2021.05.19.444907 — molecular biology — Posted on 2021-05-22
1318 Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals the potential mechanism of action of miltefosine
dos Reis, T. F.; Horta, M. A. C.; Colabardini, A. C.; Fernandes, C. M.; Silva, L. P.; Bastos, R.; Fonseca, M. V. L.; Wang, F.; Martins, C.; Rodrigues, M.; Silva Pereira, C.; Del Poeta, M.; Wong, K. H.; Goldman, G. H.
10.1101/2021.05.19.444908 — microbiology — Posted on 2021-05-22
1321 DJ-1 depletion slows down immunoaging in T-cell compartments
Zeng, N.; Capelle, C.; Baron, A.; Cire, S.; Leonard, C.; Coowar, D.; Koseki, H.; Westendorf, A. M.; Buer, J.; Brenner, D.; Krüger, R.; Balling, R.; Ollert, M.; Hefeng, F. Q.
10.1101/2021.05.21.445139 — immunology — Posted on 2021-05-22
1322 Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
Tripodo, C.; Bassani, B.; Jachetti, E.; Cancila, V.; Chiodoni, C.; Portararo, P.; Botti, L.; Vaenti, C.; Perrone, M.; Ponzoni, M.; Comoli, P.; Curti, A.; Colombo, M. P.; Sangaletti, S.
10.1101/2021.05.19.444838 — immunology — Posted on 2021-05-22
1323 Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion
Martinez-Marmol, R.; Muhaisen, A.; Cotrufo, T.; Rosello-Busquets, C.; Hernaiz-Llorens, M.; Perez-Branguli, F.; Andres, R. M.; Ros, O.; Pascual, M.; Ulloa, F.; Soriano, E.
10.1101/2021.05.20.444954 — neuroscience — Posted on 2021-05-22
1324 Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer
Thomas, C. E.; Dahl, L.; Byström, S.; Chen, Y.; Uhlen, M.; Mälarstig, A.; Czene, K.; Hall, P.; Schwenk, J. M.; Gabrielson, M.
10.1101/2021.05.20.444934 — systems biology — Posted on 2021-05-22
1325 Tumor-secreted versican co-opts myeloid IKKβ during metastasis
Spella, M.; Lamort, A. S.; Vreka, M.; Marazioti, A.; Lilis, I.; Ntaliarda, G.; Skiadas, G.; Bouloukou, E.; Giotopoulou, G. A.; Pepe, M. A.; Weiss, S. A.; Petrera, A.; Hauck, S. M.; Koch, I.; Lindner, M.; Hatz, R. A.; Behr, J.; Arendt, K. A.; Giopanou, I.; Brunn, D.; Savai, R.; Jenne, D. E.; Yull, F. E.; Blackwell, T.; Stathopoulos, G. T.
10.1101/2021.05.20.444963 — cancer biology — Posted on 2021-05-22
1326 Multi-modal adaptor-clathrin contacts drive coated vesicleassembly
Smith, S. M.; Larocque, G.; Wood, K. M.; Morris, K. L.; Roseman, A. M.; Sessions, R. B.; Royle, S. J.; Smith, C. J.
10.1101/2021.05.22.445240 — biochemistry — Posted on 2021-05-22
1329 A convolutional neural network for estimating synaptic connectivity from spike trains
Endo, D.; Kobayashi, R.; Bartolo, R.; Averbeck, B. B.; Sugase-Miyamoto, Y.; Hayashi, K.; Kenji, K.; Richmond, B. J.; Shinomoto, S.
10.1101/2020.05.05.078089 — neuroscience — Posted on 2021-05-22
1330 The effectiveness of glass beads for plating cell cultures
Prusokas, A.; Hawkins, M.; Nieduszynski, C.; Retkute, R.
10.1101/241752 — biophysics — Posted on 2021-05-22
1331 Multiview super-resolution microscopy
Wu, Y.; Han, X.; Su, Y.; Glidewell, M.; Daniels, J. S.; Liu, J.; Sengupta, T.; Rey-Suarez, I.; Fischer, R.; Patel, A.; Combs, C.; Su, J.; Wu, X.; Christensen, R.; Smith, C.; Bao, L.; Sun, Y.; Duncan, L. H.; Chen, J.; Pommier, Y.; Shi, Y.-B.; Murphy, E.; Roy, S.; Upadhyaya, A.; Colón-Ramos, D.; La Riviere, P.; Shroff, H.
10.1101/2021.05.21.445200 — bioengineering — Posted on 2021-05-22
1333 Impact of Type II LRRK2 inhibitors on signalling and mitophagy
Tasegian, A.; Singh, F.; Ganley, I.; Reith, A. D.; Alessi, D. R.
10.1101/2021.05.21.445132 — neuroscience — Posted on 2021-05-22
1336 Generation of human chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases
Ho, B. X.; Pang, J.; Phua, Q. H.; Liew, L. C.; Poh, B. M.; Chen, Y.; Loh, Y.-H.; An, O.; Yang, H. H.; Seshachalam, V. P.; Koh, J. L.; Chan, W.-K.; Ng, S.-Y.; Soh, B.-S.
10.1101/2021.05.21.445153 — cell biology — Posted on 2021-05-22
1337 Cap-dependent translation initiation monitored in living cells
Gandin, V.; English, B. P.; Freeman, M.; Leroux, L.-P.; Preibisch, S.; Walpita, D.; Jaramillo, M.; Singer, R. H.
10.1101/2021.05.21.445166 — cell biology — Posted on 2021-05-22
1340 Molecular basis for PICS-mediated piRNA biogenesis and cell division
Wang, X.; Zeng, C.; Liao, S.; Zhu, Z.; Zhang, J.; Tu, X.; Feng, X.; Guang, S.; Xu, C.
10.1101/2021.05.21.445148 — molecular biology — Posted on 2021-05-22
1341 Cryptic diversity within the Poecilochirus carabi mite species complex phoretic on Nicrophorus burying beetles: phylogeny, biogeography, and host specificity
Canitz, J.; Sikes, D. S.; Knee, W.; Baumann, J.; Haftaro, P.; Steinmetz, N.; Nave, M.; Eggert, A.-K.; Hwang, W.; Nehring, V.
10.1101/2021.05.20.443311 — zoology — Posted on 2021-05-22
1344 ASLPrep: A Generalizable Platform for Processing of Arterial Spin Labeled MRI and Quantification of Regional Brain Perfusion
Adebimpe, A.; Bertolero, M.; Dolui, S.; Cieslak, M.; Murtha, K.; Baller, E. B.; Boeve, B.; Boxer, A.; Butler, E. R.; Cook, P.; Colcombe, S.; Covitz, S.; Davatzikos, C.; Davila, D. G.; Elliott, M. A.; Flounders, M. W.; Franco, A. R.; Gur, R. E.; Gur, R. C.; Jaber, B.; McMillian, C.; the ALLFTD Consortium, ; Milham, M.; Oathe, D. J.; Olm, C. A.; Phillips, J. S.; Tackett, W.; Roalf, D. R.; Rosen, H.; Tapera, T. M.; Tisdall, M. D.; Esteban, O.; Poldrack, R. A.; Detre, J. A.; Satterthwaite, T. D.
10.1101/2021.05.20.444998 — bioengineering — Posted on 2021-05-22
1345 Golden pompano genome resource enables discovery of valuable gene determining growth traits
Luo, H.; Zhang, Y.; Ji, C.; Zhao, Y.; Peng, J.; Xu, Y.; Chen, X.; Huang, Y.; Liu, Q.; He, P.; Feng, P.; Yang, C.; Wei, P.; Yu, H.; Zheng, H.; Lin, Y.; Chen, X.
10.1101/2021.05.20.445047 — genomics — Posted on 2021-05-22
1347 The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
DIMITROVA, D. G.; BRAZANE, M.; PIGEON, J.; PAOLANTONI, C.; TAO, Y.; MARCHAND, V.; DA SILVA, B.; SCHAEFER, E.; ANGELOVA, M. T.; STARK, Z.; DELATYCKI, M.; DUDDING, T.; GECZ, J.; PLACAIS, P.-Y.; TEYSSET, L.; PREAT, T.; PITON, A.; HASSAN, B. A.; ROIGNANT, J.-Y.; MOTORIN, Y.; CARRE, C.
10.1101/2021.02.06.430044 — genetics — Posted on 2021-05-22
1352 Urinary Metabolomics from a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury
Locci, E.; Liu, J.; Pais, G.; Chighine, A.; Kahnamoei, D. A.; Xanthos, T.; Chalkias, A.; Lee, A.; Hauser, A.; Chang, J.; Rhodes, N.; d'Aloja, E.; Scheetz, M. H.
10.1101/2021.05.21.444980 — pharmacology and toxicology — Posted on 2021-05-22
1353 The Urtica Dioica Agglutinin Prevents Rabies Virus Infection in a Muscle Explant Model
Wang, X.; Terrie, L.; Wu, G.; Damme, E. V.; Thorrez, L.; Fooks, A.; Banyard, A. C.; Neyts, J.; Jochmans, D.
10.1101/2021.05.21.441744 — pathology — Posted on 2021-05-22
1355 Validated machine learning algorithm with sub-clonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity
Pyke, R. M.; Mellacheruvu, D.; Dea, S.; Abbott, C. W.; Zhang, S. V.; McDaniel, L.; Levy, E.; Bartha, G.; West, J.; Snyder, M. M.; Chen, R.; Boyle, S. M.
10.1101/2021.05.20.445052 — bioinformatics — Posted on 2021-05-22
1360 Kmerator Suite: design of specific k-mer signatures andautomatic metadata discovery in large RNA-Seq datasets.
Riquier, S.; Bessiere, C.; Guibert, B.; Bouge, A.-L.; Boureux, A.; Ruffle, F.; Audoux, J.; Gilbert, N.; Xue, H.; Gautheret, D.; Commes, T.
10.1101/2021.05.20.444982 — bioinformatics — Posted on 2021-05-22
1363 Taxon-specific or universal? Using target capture to study the evolutionary history of a rapid radiation
Yardeni, G.; Viruel, J.; Paris, M.; Hess, J.; Groot Crego, C.; de La Harpe, M.; Rivera, N.; Barfuss, M. H. J.; Till, W.; Guzman-Jacob, V.; Kroemer, T.; Lexer, C.; Paun, O.; Leroy, T.
10.1101/2021.05.20.444989 — evolutionary biology — Posted on 2021-05-22
1364 The evolution of size-dependent competitive interactions promotes species coexistence
Anaya-Rojas, J. M.; Bassar, R. D.; Potter, T.; Blanchette, A.; Callahan, S.; Framstead, N.; Reznick, D. M.; Travis, J.
10.1101/2021.05.20.445031 — ecology — Posted on 2021-05-22
1365 Universal allometry from empirical parameters
McKerral, J. C.; Kleshnina, M.; Bartle, L.; Mitchell, J. G.; Filar, J. A.
10.1101/2021.05.20.444891 — ecology — Posted on 2021-05-22
1369 Superscan: Supervised Single-Cell Annotation
Shasha, C.; Tian, Y.; Mair, F.; Miller, H. E. R.; Gottardo, R.
10.1101/2021.05.20.445014 — bioinformatics — Posted on 2021-05-22
1371 Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response
Esmaeili, V.; Tamura, K.; Muscinelli, S. P.; Modirshanechi, A.; Boscaglia, M.; Lee, A. B.; Oryshchuk, A.; Foustoukos, G.; Liu, Y.; Crochet, S.; Gerstner, W.; Petersen, C. C. H.
10.1101/2020.10.06.326678 — neuroscience — Posted on 2021-05-22
1372 homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA
Haack, A. J.; Lim, F. Y.; Kennedy, D. S.; Day, J. H.; Adams, K. N.; Lee, J. J.; Berthier, E.; Theberge, A. B.
10.1101/2021.02.08.430337 — bioengineering — Posted on 2021-05-21
1377 Larval dispersal of Brachyura in the largest estuarine / marine system in the world
de Lima, F. A.; Butturi-Gomes, D.; das Neves Pantoja, M. H.; Martinelli-Lemos, J. M.
10.1101/2021.05.21.445107 — ecology — Posted on 2021-05-21
1379 Vegetation characteristics control sediment and nutrient retention on but not underneath vegetation in floodplain meadows
Kretz, L.; Bondar-Kunze, E.; Hein, T.; Richter, R.; Schulz-Zunkel, C.; Seele-Dilbat, C.; van der Plas, F.; Vieweg, M.; Wirth, C.
10.1101/2021.05.21.445106 — ecology — Posted on 2021-05-21
1384 Colicin-mediated transport of DNA through the iron transporter FepA
Cohen-Khait, R.; Harmalkar, A.; Pham, P.; Webby, M. N.; Housden, N. G.; Elliston, E.; Hopper, J. T.; Mohammed, S.; Robinson, C. V.; Gray, J. J.; Kleanthous, C.
10.1101/2021.05.11.443673 — microbiology — Posted on 2021-05-21
1385 Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex
Campagnola, L.; Seeman, S. C.; Chartrand, T. C.; Kim, L.; Hoggarth, A.; Gamlin, C.; Ito, S.; Trinh, J.; Davoudian, P. A.; Radaelli, C.; Kim, M.-H.; Hage, T. A.; Braun, T.; Alfiler, L.; Dalley, R.; Williams, G.; Henry, A.; Mukora, A.; Kebede, S.; Sandman, D.; Bohn, P.; Andrade, J.; Larsen, R.; Teeter, C.; Daigle, T. L.; Berry, K.; Dotson, N.; Enstrom, R.; Gorham, M.; Hupp, M.; Lee, S. D.; Ngo, K.; Nicovich, P. R.; Potekhina, L.; Ransford, S.; Goldy, J.; McMillen, D.; Pham, T.; Tieu, M.; Siverts, L.; Walker, M.; Farrell, C.; Schroedter, M.; Slaughterbeck, C.; Cobbs, C.; Ellenbogen, R. G.; Gwinn,
10.1101/2021.03.31.437553 — neuroscience — Posted on 2021-05-21
1386 Deconstructing the Cortical Sources of Frequency Following Responses to Speech: A Cross-species Approach
Gnanateja, G. N.; Rupp, K.; Llanos, F.; Remick, M.; Pernia, M.; Sadagopan, S.; Teichert, T.; Abel, T.; Chandrasekaran, B.
10.1101/2021.05.17.444462 — neuroscience — Posted on 2021-05-21
1390 Decoding activity in Broca's area predicts the occurrence of auditory hallucinations across subjects
Fovet, T.; Yger, P.; Lopes, R.; de Pierrefeu, A.; Duchesnay, E.; Houenou, J.; Thomas, P.; Szaffarczyk, S.; Domenech, P.; Jardri, R.
10.1101/2021.05.21.445102 — neuroscience — Posted on 2021-05-21
1391 Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein
Elfarrash, S.; Jensen, N. M.; Ferreira, N.; Schmidt, S. I.; Gregersen, E.; Vestergaard, M. V.; Nabavi, S.; Meyer, M.; Jensen, P. H.
10.1101/2021.05.21.445104 — neuroscience — Posted on 2021-05-21
1392 Epitranscriptome changes triggered by ammonium nutrition regulate the proteome response of maritime pine roots
Ortigosa, F.; Lobato-Fernandez, C.; Perez-Claros, J. A.; Canton, F. R.; Avila, C.; Canovas, F. M.; Canas, R. A.
10.1101/2021.04.20.440618 — plant biology — Posted on 2021-05-21
1396 Identifying drivers of spatio-temporal variation in survival in four blue tit populations
Bastianelli, O.; Robert, A.; Doutrelant, C.; de Franceschi, C.; Giovannini, P.; Charmantier, A.
10.1101/2021.01.28.428563 — ecology — Posted on 2021-05-21
1400 Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy
Grünewald, B.; Wickel, J.; Hahn, N.; Hörhold, F.; Rupp, H.; Chung, H.-Y.; Haselmann, H.; Strauss, A. S.; Schmidl, L.; Hempel, N.; Grünewald, L.; Urbach, A.; Blaess, M.; Claus, R. A.; König, R.; Geis, C.
10.1101/2021.03.04.433352 — neuroscience — Posted on 2021-05-21
1403 Cell patterning by secretion-induced plasma membrane flows
Gerganova, V.; Lamas, I.; Rutkowski, D. M.; Vjestica, A.; Gallo Castro, D.; Vincenzetti, V.; Vavylonis, D.; Martin, S. G.
10.1101/2020.12.18.423457 — cell biology — Posted on 2021-05-21
1404 Comparison of CPU and GPU Bayesian Estimates of Fibre Orientations from Diffusion MRI
Kim, D. H. C.; Williams, L. J.; Hernandez-Fernandez, M.; Bjornson, B. H.
10.1101/703835 — neuroscience — Posted on 2021-05-21
1406 Prenatal Stress Dysregulates Resting-State Functional Connectivity and Sensory Motifs
Rezaei, Z.; Jafari, Z.; Afrashteh, N.; Torabi, R.; Singh, S.; Kolb, B. E.; Davidsen, J.; Mohajerani, M. H.
10.1101/2020.08.26.268359 — neuroscience — Posted on 2021-05-21
1408 Leveraging single-cell ATAC-seq to identify disease-critical fetal and adult brain cell types
Kim, S. S.; Jagadeesh, K.; Dey, K. K.; Shen, A. Z.; Raychaudhuri, S.; Kellis, M.; Price, A. L.
10.1101/2021.05.20.445067 — genetics — Posted on 2021-05-21
1410 Challenges of γ9δ2TCR affinity maturation when using phage display
Kramer, L.; Demuysere, M.; van Diest, E.; Beringer, D.; Kuball, J.
10.1101/2021.05.20.445024 — immunology — Posted on 2021-05-21
1412 KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury.
Al-bataineh, M. M.; Kinlough, C. L.; Mi, Z.; Jackson, E. K.; Mutchler, S.; Emlet, D. R.; Kellum, J. A.; Hughey, R. P.
10.1101/2021.05.20.445053 — pathology — Posted on 2021-05-21
1413 Wnt/β-catenin inhibition disrupts drug-tolerance in isogenic carboplatin-resistant models of Triple-Negative Breast Cancer.
Abreu de Oliveira, W. A.; Moens, S.; El Laithy, Y.; van der Veer, B. K.; Athanasouli, P.; Cortesi, E. E.; Baietti, M. F.; Koh, K. P.; Ventura, J.-J.; Amant, F.; Annibali, D.; Lluis, F.
10.1101/2021.05.21.443409 — cancer biology — Posted on 2021-05-21
1414 Analysis of Normal Levels of Urine and Plasma Free Glycosaminoglycans in Adults
Bratulic, S.; Limeta, A.; Maccari, F.; Galeotti, F.; Volpi, N.; Nielsen, J.; Gatto, F.
10.1101/2021.05.21.445098 — biochemistry — Posted on 2021-05-21
1415 An optimized protocol for dual RNA-Seq of human macrophages infected with Mycobacterium avium
Schildkraut, J. A.; Koeken, V. A. C. M.; Coolen, J. P. M.; van Crevel, R.; van Ingen, J.
10.1101/2021.05.20.443437 — genomics — Posted on 2021-05-21
1416 A cellular and molecular portrait of endometriosis subtypes
Fonseca, M. A. S.; Wright, K. N.; Lin, X.; Abbasi, F.; Haro, M.; Sun, J.; Hernandez, L.; Orr, N. L.; Hong, J.; Choi-Kuaea, Y.; Maluf, H. M.; Balzer, B. L.; Cass, I.; Truong, M.; Wang, Y.; Pisarska, M. D.; Dinh, H.; EL-Naggar, A.; Huntsman, D.; Anglesio, M. S.; Goodman, M. T.; Medeiros, F.; Siedhoff, M.; Lawrenson, K.
10.1101/2021.05.20.445037 — genomics — Posted on 2021-05-21
1419 Human genetic diversity modifies therapeutic gene editing off-target potential
Cancellieri, S.; Zeng, J.; Lin, L. Y.; Masillo, F.; Nguyen, A.; Bombieri, N.; Ciuculescu, F.; Katta, V.; Tsai, S.; Armant, M.; Giugno, R.; Bauer, D. E.; Pinello, L.
10.1101/2021.05.20.445054 — genetics — Posted on 2021-05-21
1421 Host stress hormones affect host, but not vector, infectiousness for West Nile virus
Martin, L. B.; Kernbach, M. E.; Koller, K.; Burkett-Cadena, N. D.; Unnasch, T.
10.1101/2021.05.20.444978 — ecology — Posted on 2021-05-21
1422 Understanding the complexity of Epimorphic Regeneration in zebrafish: A Transcriptomic and Proteomic approach.
Banu, S.; Gaur, N.; Nair, S.; Ravikrishnan, T.; Khan, S.; Mani, S.; Bharathi, S.; Mandal, K.; Kuram, N. A.; Vuppaladadium, S.; Murthy, C. L. N.; Quoseena, M.; Sarath Babu, N.; Idris, M. M.
10.1101/2021.05.20.445069 — developmental biology — Posted on 2021-05-21
1423 The Chlamydomonas mitochondrial ribosome: how to build a ribosome from RNA fragments
WALTZ, F.; Salinas-Giege, T.; Englmeier, R.; Meichel, H.; Soufari, H.; Kuhn, L.; Pfeffer, S.; Foerster, F.; Engel, B. D.; Giege, P.; Drouard, L.; Hashem, Y.
10.1101/2021.05.21.445086 — molecular biology — Posted on 2021-05-21
1427 SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model
Zhuang, A.; Yang, C.; Liu, Y.; Tan, Y.; Bond, S. T.; Walker, S.; Sikora, T.; Sharma, A.; de Haan, J. B.; Meikle, P. J.; Coughlan, M. T.; Calkin, A. C.; Drew, B. G.
10.1101/2021.05.20.443346 — physiology — Posted on 2021-05-21
1428 Genetic Inhibition of Serum Glucocorticoid Kinase 1 Prevents Obesity-related Atrial Fibrillation
Bapat, A.; Li, G.; Xiao, L.; Hulsmans, M.; Schloss, M. J.; Iwamoto, Y.; Tedeschi, J.; Yang, X.; Nahrendorf, M.; Rosenzweig, A.; Ellinor, P.; Das, S.; Milan, D.
10.1101/2021.05.20.444790 — physiology — Posted on 2021-05-21
1429 MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling
Furnish, M.; Boulton, D. P.; Genther, V.; Ellinwood, M. L.; Romero, L.; Lucia, M. S.; Cramer, S. D.; Caino, M. C.
10.1101/2021.05.20.444992 — cancer biology — Posted on 2021-05-21
1432 Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike
MacGowan, S. A.; Barton, M. I.; Kutuzov, M.; Dushek, O.; van der Merwe, P. A.; Barton, G. J.
10.1101/2021.05.21.445118 — genetics — Posted on 2021-05-21
1433 A genetic switch for male UV-iridescence in an incipient species pair of sulphur butterflies
Ficarrotta, V.; Hanly, J. J.; Loh, L. S.; Francescutti, C. M.; Ren, A.; tunstrom, k.; Wheat, C. W.; Porter, A. H.; Counterman, B. A.; Martin, A.
10.1101/2021.05.21.445125 — evolutionary biology — Posted on 2021-05-21
1434 Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis
Majee, S.; Roy Chowdhury, A.; Chattopadhyay, A.; Pinto, R.; Agharkar, A.; Chakravortty, D.; Basu, S.
10.1101/2021.05.20.445070 — microbiology — Posted on 2021-05-21
1435 Development and Application of Cas13a-based Diagnostic Assay for Neisseria Gonorrhoeae Detection and Identification of Azithromycin Resistance
Luo, H.; Chen, W.; Mai, Z.-D.; Lin, X.; Yang, J.; Zeng, L.; Pan, Y.; Xie, Q.; Xu, Q.; Li, X.; Liao, Y.; Feng, Z.; Ou, J.; Qin, X.; Zheng, h.
10.1101/2021.05.20.445076 — microbiology — Posted on 2021-05-21
1439 ESCA pipeline: Easy-to-use SARS-CoV-2 genome Assembler
Rueca, M.; Giombini, E.; Messina, F.; Bartolini, B.; Di Caro, A.; Capobianchi, M. R.; Gruber, C. E. M.
10.1101/2021.05.21.445156 — bioinformatics — Posted on 2021-05-21
1440 Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant
Gray, L. T.; Raczy, M. M.; Briquez, P. S.; Marchell, T. M.; Alpar, A. T.; Wallace, R. P.; Volpatti, L. R.; Sasso, M. S.; Cao, S.; Nguyen, M.; Mansurov, A.; Budina, E.; Watkins, E. A.; Solanki, A.; Mitrousis, N.; Reda, J. W.; Yu, S. S.; Tremain, A. C.; Wang, R.; Nicolaescu, V.; Furlong, K.; Dvorkin, S.; Manicassamy, B.; Randall, G.; Wilson, D. S.; Kwissa, M.; Swartz, M. A.; Hubbell, J. A.
10.1101/2021.05.20.445060 — bioengineering — Posted on 2021-05-21
1441 Deamidation drives molecular aging of the SARS-CoV-2 spike receptor-binding motif
Lorenzo, R.; Defelipe, L. A.; Aliperti, L.; Niebling, S.; Custodio, T. F.; Löw, C.; Schwarz, J. J.; Remans, K.; Craig, P. O.; Otero, L. H.; Klinke, S.; Garcia-Alai, M.; Sanchez, I. E.; Alonso, L. G.
10.1101/2021.05.20.445042 — biochemistry — Posted on 2021-05-21
1442 Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses
Rebendenne, A.; Roy, P.; Bonaventure, B.; Chaves Valadao, A. L.; Desmarets, L.; Rouille, Y.; Tauziet, M.; Arnaud-Arnould, M.; Giovannini, D.; Lee, Y.; DeWeirdt, P.; Hegde, M.; Garcia de Gracia, F.; McKellar, J.; Wencker, M.; Dubuisson, J.; Belouzard, S.; Moncorge, O.; Doench, J. G.; Goujon, C.
10.1101/2021.05.19.444823 — microbiology — Posted on 2021-05-21
1443 6',6'-Difluoro-aristeromycin is a potent inhibitor of MERS-coronavirus replication
S. Ogando, N. S.; Zevenhoven-Dobbe, J.; Jarhad, D.; Tripathi, S. K.; Lee, H. W.; Jeong, L. S.; Snijder, E. J.; Posthuma, C. C.
10.1101/2021.05.20.445077 — microbiology — Posted on 2021-05-21
1444 Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
Guo, H.; Hu, B.; Si, H.-r.; Zhu, Y.; Zhang, W.; Li, B.; Li, A.; Geng, R.; Lin, H.-F.; Yang, X.-L.; Zhou, P.; Shi, Z.
10.1101/2021.05.21.445091 — microbiology — Posted on 2021-05-21
1445 Probenecid Inhibits SARS-CoV-2 Replication In Vivo and In Vitro
Murray, J.; Hogan, R. J.; Martin, D. E.; Blahunka, K.; Sancillo, F.; Balyan, R.; Lovern, M.; Still, R.; Tripp, R. A.
10.1101/2021.05.21.445119 — microbiology — Posted on 2021-05-21
1446 Engineered acetoacetate-inducible whole-cell biosensors based on the AtoSC two-component system
Rutter, J. W.; Dekker, L.; Fedorec, A. J. H.; Gonzales, D. T.; Wen, K. Y.; Tanner, L. E.; Donovan, E.; Ozdemir, T.; Thomas, G. M.; Barnes, C. P.
10.1101/035972 — synthetic biology — Posted on 2021-05-21
1447 A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations
Bertoglio, F.; Fühner, V.; Ruschig, M.; Heine, P. A.; Abasi, L.; Klünemann, T.; Rand, U.; Meier, D.; Langreder, N.; Steinke, S.; Ballmann, R.; Schneider, K.-T.; Roth, K. D. R.; Kuhn, P.; Riese, P.; Schäckermann, D.; Korn, J.; Koch, A.; Chaudhry, M. Z.; Eschke, K.; Kim, Y.; Zock-Emmenthal, S.; Becker, M.; Scholz, M.; Moreira, G. M. S. G.; Wenzel, E. V.; Russo, G.; Garritsen, H. S. P.; Casu, S.; Gerstner, A.; Roth, G.; Adler, J.; Trimpert, J.; Hermann, A.; Schirrmann, T.; Dübel, S.; Frenzel, A.; Van den Heuvel, J.; Cicin-Sain, L.; Schubert, M.; Hust, M.
10.1101/2020.12.03.409318 — bioengineering — Posted on 2021-05-21
1449 The proportional recovery rule redux: Arguments for its biological and predictive relevance
Goldsmith, J.; Kitago, T.; Garcia de la Garza, A.; Kundert, R.; Luft, A.; Stinear, C. M.; Byblow, W. D.; Kwakkel, G.; Krakauer, J. W.
10.1101/2021.05.20.445022 — neuroscience — Posted on 2021-05-21
1451 The Neural Determinants of Beauty
Yang, T.; Formuli, A.; Paolini, M.; Zeki, S.
10.1101/2021.05.21.444999 — neuroscience — Posted on 2021-05-21
1452 Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer's Disease
Calafate, S.; Ozturan, G.; Thrupp, N.; Vanderlinden, J.; Chen, W.-T.; Fiers, M.; Lu, A.; Creemers, E.; Craessaerts, K.; Vandenbempt, J.; van Boekhold, L.; Poovathingal, S.; Davie, K.; Thal, D. R.; Wierda, K.; de Strooper, B.; de Wit, J.
10.1101/2021.05.21.445007 — neuroscience — Posted on 2021-05-21
1453 GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer
Brun, S.; Pascussi, J.-M.; Gifu, E. P.; Bestion, E.; Macek-Jilkova, Z.; Wang, G.; Bassissi, F.; Mezouar, S.; Courcamberck, J.; Merle, P.; Decaens, T.; Pannequin, J.; Halfon, P.; Caron de Fromentel, C.
10.1101/2020.12.21.423741 — cancer biology — Posted on 2021-05-21
1455 FIND-IT: Ultrafast mining of genome diversity
Knudsen, S.; Wendt, T.; Dockter, C.; Thomsen, H. C.; Rasmussen, M.; Joergensen, M. E.; Lu, Q.; Voss, C.; Murozuka, E.; Oesterberg, J. T.; Harholt, J.; Braumann, I.; Cuesta-Seijo, J. A.; Bodevin, S.; Petersen, L. T.; Carciofi, M.; Pedas, P. R.; Husum, J. O.; Nielsen, M. T. S.; Nielsen, K.; Jensen, M. K.; Moeller, L. A.; Gojkovic, Z.; Striebeck, A.; Lengeler, K.; Fennessy, R. T.; Katz, M.; Sanchez, R. G.; Solodovnikova, N.; Forster, J.; Olsen, O.; Moeller, B. L.; Fincher, G. B.; Skadhauge, B.
10.1101/2021.05.20.444969 — genetics — Posted on 2021-05-21
1456 Anaerobic derivates of mitochondria and peroxisomes in the free-living amoeba Pelomyxa schiedti revealed by single-cell genomics
Zahonova, K.; Treitli, S. C.; Le, T.; Skodova-Sverakova, I.; Hanouskova, P.; Cepicka, I.; Tachezy, J.; Hampl, V.
10.1101/2021.05.20.444135 — evolutionary biology — Posted on 2021-05-21
1457 Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity
Nanishi, E.; Borriello, F.; O'Meara, T. R.; McGrath, M. E.; Saito, Y.; Haupt, R. E.; Seo, H.-S.; van Haren, S. D.; Brook, B.; Chen, J.; Diray-Arce, J.; Doss-Gollin, S.; De Leon, M.; Chew, K.; Menon, M.; Song, K.; Xu, A. Z.; Caradonna, T. M.; Feldman, J.; Hauser, B. M.; Schmidt, A. G.; Sherman, A. C.; Baden, L. R.; Ernst, R. K.; Dillen, C.; Weston, S. M.; Johnson, R. M.; Hammond, H. L.; Mayer, R.; Burke, A.; Bottazzi, M. E.; Hotez, P. J.; Strych, U.; Chang, A.; Yu, J.; Barouch, D. H.; Dhe-Paganon, S.; Zanoni, I.; Ozonoff, A.; Frieman, M.; Levy, O.; Dowling, D. J.
10.1101/2021.05.20.444848 — immunology — Posted on 2021-05-21
1458 Altered hippocampal transcriptome dynamics following sleep deprivation
Gaine, M. E.; Bahl, E.; Chatterjee, S.; Michaelson, J. J.; Abel, T.; Lyons, L. C.
10.1101/2021.05.20.445021 — neuroscience — Posted on 2021-05-21
1460 The immune Rysto receptor recognizes a broadly conserved feature of potyviral coat proteins
Grech-Baran, M.; Witek, K.; Poznanski, J.; Grupa-Urbanska, A.; Malinowski, T.; Lichocka, M.; Jones, J. D.; Hennig, J.
10.1101/2021.05.20.444601 — plant biology — Posted on 2021-05-21
1461 The role of AUX1 during lateral root development in the domestication of the model C4 grass Setaria italica
Tang, S.; Shahriari, M.; Xiang, J.; Pasternak, T.; Igolkina, A. A.; Aminizade, S.; Zhi, H.; Gao, Y.; Roodbarkelari, F.; Sui, Y.; Jia, G.; Wu, C.; Li, X.; Meshcheryakov, G.; Samsonova, M. G.; Diao, X.; Palme, K.; Teale, W.
10.1101/2021.05.20.444970 — plant biology — Posted on 2021-05-21
1462 Identifying cancer pathway dysregulations using differential causal effects
Jablonski, K. P.; Pirkl, M. F.-X.; Cevid, D.; Buehlmann, P.; Beerenwinkel, N.
10.1101/2021.05.20.444965 — bioinformatics — Posted on 2021-05-21
1464 Bioluminescent Synthetic Cells Communicate with Natural Cells and Self-Activate Light-Responsive Proteins
Adir, O.; Abel, R.; Albalak, M. R.; Weiss, L. E.; Chen, G.; Gruber, A.; Staufer, O.; Shklover, J.; Shainsky-Roitman, J.; Platzman, I.; Gepstein, L.; Shechtman, Y.; Horwitz, B. A.; Schroeder, A.
10.1101/2021.05.20.444896 — bioengineering — Posted on 2021-05-21
1466 Species boundaries in the Agrobacterium tumefaciens complex and multi-level modular evolution of their antibacterial type VI secretion system and tumor-inducing plasmids
Chou, L.; Lin, Y.-C.; Haryono, M.; Santos, M. N. M.; Cho, S.-T.; Weisberg, A. J.; Wu, C.-F.; Chang, J. H.; Lai, E.-M.; Kuo, C.-H.
10.1101/2021.05.20.444927 — genomics — Posted on 2021-05-21
1468 Differentially methylated regions and methylation QTLs for teen depression and early puberty in the Fragile Families Child Wellbeing Study
De Vito, R.; Grabski, I. N.; Aguiar, D.; Schneper, L. M.; Verma, A. N.; Castillo-Fernandez, J. E.; Mitchell, C.; Bell, J. T.; McLanahan, S.; Notterman, D. A.; Engelhardt, B. E.
10.1101/2021.05.20.444959 — genomics — Posted on 2021-05-21
1469 Rare copy number variants (CNVs) and breast cancer risk
Dennis, J.; Tyrer, J. P.; Walker, L. C.; Michailidou, K.; Dorling, L.; Bolla, M. K.; Wang, Q.; Ahearn, T. U.; Andrulis, I. L.; Anton-Culver, H.; Antonenkova, N. N.; Arndt, V.; Aronson, K. J.; Beane Freeman, L. E.; Beckmann, M. W.; Behrens, S.; Benitez, J.; Bermisheva, M.; Bogdanova, N. V.; Bojesen, S. E.; Brenner, H.; Castelao, J. E.; Chang-Claude, J.; Chenevix-Trench, G.; Clarke, C. L.; Collaborators, N.; Collee, J. M.; Consortium, C.; Couch, F. J.; Cox, A.; Cross, S. S.; Czene, K.; Devilee, P.; Dork, T.; Dossus, L.; Eliassen, A. H.; Eriksson, M.; Evans, D. G.; Fasching, P. A.; Figueroa, J.;
10.1101/2021.05.20.444828 — genetics — Posted on 2021-05-21
1471 The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization
Edmunds, G. L.; Wong, C. W. L.; Ambler, R.; Milodowski, E.; Alamir, H.; Cross, S. J.; Galea, G.; Wuelfing, C.; Morgan, D. J.
10.1101/2021.05.20.444944 — immunology — Posted on 2021-05-21
1472 TLR2 on CD4+ and CD8+ T cells promotes late control of Mycobacterium tuberculosis infection
Reba, S.; Li, Q.; Onwuzulike, S.; Nagy, N.; Parker, K.; Umphred-Wilson, K.; Shukla, S.; Harding, C. V.; Boom, W. H.; E. Rojas, R.
10.1101/2021.05.19.444905 — immunology — Posted on 2021-05-21
1473 Establishment of pan-Influenza A (H1-H18) and pan-Influenza B (pre-split, Vic/Yam) Pseudotype Libraries for efficient vaccine antigen selection
Del Rosario, J. M.; da Costa, K.; Asbach, B.; Ferrara, F.; Ferrari, M.; Wells, D.; Mann, G. S.; Ameh, V. O.; Sabeta, C. T.; Banyard, A. C.; Kinsley, R.; Scott, S. D.; Wagner, R.; Heeney, J. L.; Carnell, G. W.; Temperton, N. J.
10.1101/2021.05.20.444964 — immunology — Posted on 2021-05-21
1476 Sylites: Multipurpose markers for the visualization of inhibitory synapses
Khayenko, V.; Schulte, C.; Reis, S. L.; Avraham, O.; Schietroma, C.; Worschech, R.; Nordblom, N. F.; Kachler, S.; Villmann, C.; Heinze, K.; Schlosser, A.; Furman-Schueler, O.; Tovote, P.; Specht, C. G.; Maric, H. M.
10.1101/2021.05.20.444651 — neuroscience — Posted on 2021-05-21
1481 GPI anchor remodeling by the plant PGAP1 ortholog HLD1 is essential for Papaver self-incompatibility
Lin, Z.; Xie, F.; Trivino, M.; Zhao, T.; Coppens, F.; Sterck, L.; Bosch, M.; Franklin-Tong, V. E.; Nowack, M. K.
10.1101/2021.05.20.444919 — plant biology — Posted on 2021-05-21
1482 Cross-species identification of cancer-resistance associated genes uncovers their relevance to human cancer risk
Nair, N. U.; Cheng, K.; Naddaf, L.; Sharon, E.; Pal, L. R.; Rajagopal, P. S.; Unterman, I.; Aldape, K.; Hannenhalli, S.; Day, C.-P.; Tabach, Y.; Ruppin, E.
10.1101/2021.05.19.444895 — cancer biology — Posted on 2021-05-21
1483 Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease
Kratz, J. R.; Li, J. Z.; Tsui, J.; Lee, J. C.; Ding, V. W.; Rao, A. A.; Mann, M. J.; Chan, V.; Combes, A. R.; Krummel, M. F.; Jablons, D. M.
10.1101/2021.05.20.444915 — cancer biology — Posted on 2021-05-21
1488 NMR chemical shift assignments of RNA oligonucleotides to expand the RNA chemical shift database
Liu, Y.; Kotar, A.; Hodges, T. L.; Abdallah, K.; Taleb, M. H.; Bitterman, B. A.; Jaime, S.; Schaubroeck, K. J.; Mathew, E.; Morgenstern, N. W.; Lohmeier, A.; Page, J. L.; Ratanapanichkich, M.; Arhin, G.; Johnson, B. L.; Cherepanov, S.; Moss, S. C.; Zuniga, G.; Tilson, N. J.; Yeoh, Z. C.; Johnson, B. A.; Keane, S. C.
10.1101/2021.05.20.444957 — biophysics — Posted on 2021-05-21
1490 Structures of the human cholecystokinin receptors in complex with agonists and antagonists
Zhang, X.; He, C.; Wang, M.; zhou, Q.; Yang, D.; Zhu, Y.; Feng, W.; Zhang, H.; Dai, A.; Chu, X.; Wang, J.; Yang, Z.; Jiang, Y.; Sensfuss, U.; Tan, Q.; Han, S.; Reedtz-Runge, S.; Xu, H. E.; Zhao, S.; Wang, M.-W.; Wu, B.; Zhao, Q.
10.1101/2021.05.19.444887 — biophysics — Posted on 2021-05-21
1492 Protein detection in blood with single-molecule imaging
Mao, C.-P.; Wang, S.-C.; Su, Y.-P.; Tseng, S.-H.; He, L.; Wu, A.; Xiao, J.; Roden, R.; Hung, C.-F.
10.1101/2021.05.19.444873 — biophysics — Posted on 2021-05-21
1493 Diel light cycles affect phytoplankton competition in the global ocean
Tsakalakis, I.; Follows, M. J.; Dutkiewicz, S.; Follett, C. L.; Vallino, J. J.
10.1101/2021.05.19.444874 — ecology — Posted on 2021-05-21
1495 Sub-lethal radiation-induced senescence impairs resolution programs and drives cardiovascular inflammation
Sadhu, S.; Decker, C.; Sansbury, B. E.; Marinello, M.; Seyfried, A.; Howard, J.; Mori, M.; Hosseini, Z.; Arunachalam, T.; Finn, A. V.; Lamar, J. M.; Jourd'heuil, D.; Guo, L.; MacNamara, K. C.; Spite, M.; Fredman, G.
10.1101/2021.05.19.444879 — immunology — Posted on 2021-05-21
1498 Maternal separation affects fronto-cortical activity in rat pups during dam-pup interactions and behavioral transitions
Ranger, M.; Behring, T.; Kaidbey, J. H.; Anwar, M.; Lipshutz, A. B.; Mollicone, I.; Hassan, G.; Fasano, K.; Hinz, N. K.; Ludwig, R. J.; Myers, M. M.; Welch, M. G.; Dumitriu, D.
10.1101/2021.05.19.444831 — neuroscience — Posted on 2021-05-21
1499 The cellular architecture of microvessels, pericytes and neuronal cell types in organizing regional brain energy homeostasis in mice
Wu, Y.-t.; Bennett, H. C.; Chon, U.; Vanselow, D. J.; Zhang, Q.; Munoz-Castaneda, R.; Cheng, K. C.; Osten, P.; Drew, P. J.; Kim, Y.
10.1101/2021.05.19.444854 — neuroscience — Posted on 2021-05-21
1500 A multi-scale in silico mouse model for insulin resistance and humanoid type 2 diabetes
Simonsson, C.; Lövfors, W.; Bergqvist, N.; Gennemark, P.; Stenkula, K. G.; Cedersund, G.
10.1101/2021.05.19.443124 — systems biology — Posted on 2021-05-21
1502 Predicting Moisture Content During Maize Nixtamalization Using Machine Learning with NIR Spectroscopy
Burns, M.; Renk, J.; Eickholt, D.; Gilbert, A.; Hattery, T.; Holmes, M.; Anderson, N.; Waters, A.; Kalambur, S.; Flint-Garcia, S.; Yandeau-Nelson, M.; Annor, G.; Hirsch, C.
10.1101/2021.05.19.444884 — plant biology — Posted on 2021-05-21
1504 Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
Song, Y.; Soto, J.; Chen, B.; Zhao, W.; Hoffman, T.; Zhu, N.; Peng, Q.; Ly, C.; Wong, P. K.; Wang, Y.; Rowat, A. C.; Kurdistani, S. K.; Li, S.
10.1101/2021.05.19.444886 — biophysics — Posted on 2021-05-21
1512 Implementation of a TMS-fMRI system: A primer
Alamian, G.; Ge, R.; MacMillan, E. L.; Barlow, L.; Humaira, A.; Gregory, E.; Vila-Rodriguez, F.
10.1101/2021.05.19.444738 — neuroscience — Posted on 2021-05-21
1518 Impact of trimethoprim on the river microbiome and antimicrobial resistance.
Delaney, J.; Raguideau, S.; Holden, J.; Zhang, L.; Tipper, H.; Hill, G.; Klumper, U.; Zhang, T.; James, R. S.; Travis, E. R.; Bowes, M. J.; Hawkey, P. M.; Lindstrom, H. S.; Tang, C.; Gaze, W. H.; Mead, A.; Quince, C. R.; Singer, A. C.; Wellington, E. M.
10.1101/2020.06.05.133348 — microbiology — Posted on 2021-05-21
1522 Clumpy coexistence in phytoplankton: The role of functional similarity in community assembly
Graco-Roza, C.; Segura, A. M.; Kruk, C.; Domingos, P.; Soininen, J.; Marinho, M. M.
10.1101/869966 — ecology — Posted on 2021-05-21
1523 The Medaka Inbred Kiyosu-Karlsruhe (MIKK) Panel
Fitzgerald, T. W.; Brettell, I.; Leger, A.; Wolf, N.; Kusminski, N.; Monahan, J.; Barton, C.; Herder, C.; Aadepu, N.; Gierten, J.; Becker, C.; Hammouda, O.; Hasel, E.; Lischik, C.; Lust, K.; Tsingos, E.; Tavhelidse, T.; Thumberger, T.; Welz, B.; Khouja, N.; Naruse, K.; Birney, E.; Wittbrodt, J.; Loosli, F.
10.1101/2021.05.17.444412 — genomics — Posted on 2021-05-21
1524 Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
Leger, A.; Brettell, I.; Monahan, J.; Barton, C.; Wolf, N.; Kusminski, N.; Herder, C.; Aadepu, N.; Becker, C.; Gierten, J.; Hammouda, O.; Hasel, E.; Lischik, C.; Lust, K.; Suzuki, R.; Tavhelidse, T.; Thumberger, T.; Tsingos, E.; Watson, P.; Welz, B.; Naruse, K.; Loosli, F.; Wittbrodt, J.; Birney, E.; Fitzgerald, T. W.
10.1101/2021.05.17.444424 — genomics — Posted on 2021-05-21
1525 Scaling of cellular proteome with ploidy
Yahya, G.; Menges, P.; Ngandiri, D. A.; Schulz, D.; Wallek, A.; Kulak, N. A.; Mann, M.; Cramer, P.; Savage, V.; Raeschle, M.; Storchova, Z.
10.1101/2021.05.06.442919 — cell biology — Posted on 2021-05-21
1526 Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness
Giraud, E.; Varet, H.; Legendre, R.; Sismeiro, O.; Aubry, F.; Dabo, S.; Dickson, L. B.; Valiente Moro, C.; Lambrechts, L.
10.1101/2021.05.20.444942 — microbiology — Posted on 2021-05-21
1531 Chained structure of dimeric F1-like ATPase in Mycoplasma mobile gliding machinery
Toyonaga, T.; Kato, T.; Kawamoto, A.; Kodera, N.; Hamaguchi, T.; Tahara, Y. O.; Ando, T.; Namba, K.; Miyata, M.
10.1101/2021.04.06.438750 — microbiology — Posted on 2021-05-20
1534 Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath
Ren, X.; Wang, M.; Li, B.; Jamieson, K.; Zheng, L.; Jones, I. R.; Li, B.; Takagi, M. A.; Lee, J.; Maliskova, L.; Tam, T. W.; Yu, M.; Hu, R.; Lee, L.; Abnousi, A.; Li, G.; Li, Y.; Hu, M.; Ren, B.; Wang, W.; Shen, Y.
10.1101/2021.02.19.431931 — genomics — Posted on 2021-05-20
1535 A complex interplay between balancing selection and introgression maintains a genus-wide alternative life-history strategy.
tunström, k.; Woronik, A.; Hanly, J. J.; Rastas, P.; Chichvarkhin, A.; Warren, A. D.; Kawahara, A.; Schoville, S. D.; Ficarrotta, V.; Porter, A. H.; Watt, W. B.; Martin, A.; Wheat, C. W.
10.1101/2021.05.20.445023 — evolutionary biology — Posted on 2021-05-20
1538 The gatekeeper of Yersinia type III secretion is under RNA thermometer control
Pienkoss, S.; Javadi, S.; Chaoprasid, P.; Nolte, T.; Twittenhoff, C.; Dersch, P.; Narberhaus, F.
10.1101/2021.05.20.444929 — microbiology — Posted on 2021-05-20
1539 Biphasic effects of IL-27 during Staphylococcus aureus implant-associated osteomyelitis in mice
Morita, Y.; Franchini, A. M.; Owen, J. R.; Martinez, J. C.; Daiss, J. L.; de Mesy Bentley, K. L.; Kates, S. L.; Schwarz, E. M.; Muthukrishnan, G.
10.1101/2021.05.20.444931 — immunology — Posted on 2021-05-20
1544 Development of a Low-Cost System for Simultaneous Longitudinal Biological Imaging
Ly, V. T.; Baudin, P. V.; Pansodtee, P.; Jung, E. A.; Voitiuk, K.; Rosen, Y.; Willsey, H. R.; Mantalas, G. L.; Seiler, S. T.; Selberg, J. A.; Cordero, S. A.; Ross, J. M.; Rolandi, M.; Pollen, A. A.; Nowakowski, T. J.; Haussler, D.; Mostajo-Radji, M. A.; Salama, S.; Teodorescu, M.
10.1101/2021.05.17.443454 — bioengineering — Posted on 2021-05-20
1545 Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels
Baseggio, M.; Murray, M.; Wu, D.; Ziegler, G.; Kaczmar, N.; Chamness, J.; Hamilton, J. P.; Buell, C. R.; Vatamaniuk, O. K.; Buckler, E. S.; Smith, M. E.; Baxter, I.; Tracy, W. F.; Gore, M. A.
10.1101/2021.02.19.432009 — genetics — Posted on 2021-05-20
1549 Light-weight Electrophysiology Hardware and Software Platform for Cloud-Based Neural Recording Experiments
Voitiuk, K.; Geng, J.; Keefe, M. G.; Parks, D. F.; Sanso, S. E.; Hawthorne, N.; Freeman, D. B.; Mostajo-Radji, M. A.; Nowakowski, T. J.; Salama, S. R.; Teodorescu, M.; Haussler, D.
10.1101/2021.05.18.444685 — neuroscience — Posted on 2021-05-20
1550 Divergent sex differences in functional brain connectivity networks in excessively drinking C57BL/6J mice
Bloch, S.; Rinker, J. A.; Smith, A. C.; Shiromani, P. J.; Wheeler, D.; Azevedo, R.; Gandhi, S.; Hoffman, M.; Mulholland, P. J.
10.1101/2021.05.19.444869 — neuroscience — Posted on 2021-05-20
1552 Atypical genomic cortical patterning in autism with poor early language outcome
Lombardo, M. V.; Eyler, L.; Pramparo, T.; Gazestani, V. H.; Hagler, D. J.; Chen, C.-H.; Dale, A. M.; Seidlitz, J.; Bethlehem, R. A. I.; Bertelsen, N.; Carter Barnes, C.; Lopez, L.; Campbell, K.; Lewis, N. E.; Pierce, K.; Courchesne, E.
10.1101/2020.08.18.253443 — neuroscience — Posted on 2021-05-20
1553 DiversityScanner: Robotic discovery of small invertebrates with machine learning methods
Wuehrl, L.; Pylatiuk, C.; Giersch, M.; Lapp, F.; von Rintelen, T.; Balke, M.; Schmidt, S.; Cerretti, P.; Meier, R.
10.1101/2021.05.17.444523 — zoology — Posted on 2021-05-20
1555 MicroMator: Open and Flexible Software for Reactive Microscopy
Fox, Z. R.; Fletcher, S.; Fraisse, A.; Aditya, C.; Sosa-Carrillo, S.; Gilles, S.; Bertaux, F.; Ruess, J.; Batt, G.
10.1101/2021.03.12.435206 — systems biology — Posted on 2021-05-20
1556 The Visual Dictionary of Antimicrobial Stewardship, Infection Control, and Institutional Surveillance
Keizer, J.; Luz, C. F.; Sinha, B.; van Gemert-Pijnen, L.; Albers, C. J.; Beerlage-de Jong, N.; Glasner, C.
10.1101/2021.05.19.444819 — scientific communication and education — Posted on 2021-05-20
1558 BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB.
McNeal, A. S.; Belote, R. L.; Zeng, H.; Barker, K.; Torres, R.; Curtin, M.; Shain, A. H.; Andtbacka, R. H.; Holmen, S. L.; Lum, D. H.; McCalmont, T.; VanBrocklin, M. W.; Grossman, D.; Wei, M. L.; Lang, U. E.; Judson-Torres, R. L.
10.1101/2020.05.21.109397 — cancer biology — Posted on 2021-05-20
1559 Targeting of Protein Kinase CK2 in Acute Myeloid Leukemia Cells Using the Clinical-Grade Synthetic-Peptide CIGB-300
Rosales, M.; Perez, G. V.; Ramon, A. C.; Cruz, Y.; Rodriguez-Ulloa, A.; Besada, V.; Ramos, Y.; Vazquez-Blomquist, D.; Caballero, E.; Aguilar, D.; Gonzalez, L. J.; Zettl, K.; Wisniewski, J. R.; Ke, Y.; Perera, Y.; Perea, S. E.
10.1101/2021.05.19.444866 — cancer biology — Posted on 2021-05-20
1561 Systematic tissue annotations of -omics samples by modeling unstructured metadata
Hawkins, N. T.; Maldaver, M.; Yannakopoulos, A.; Guare, L. A.; Krishnan, A.
10.1101/2021.05.10.443525 — bioinformatics — Posted on 2021-05-20
1562 Single-component optogenetic tools for inducible RhoA GTPase signaling
Berlew, E. E.; Kuznetsov, I. A.; Yamada, K. K.; Bugaj, L. J.; Boerckel, J. D.; Chow, B. Y.
10.1101/2021.02.01.429147 — bioengineering — Posted on 2021-05-20
1564 Transcriptomics of improved fruit retention by hexanal in 'Honeycrisp' reveals hormonal crosstalk and reduced cell-wall remodelling in the fruit-abscission zone
Sriskantharajah, K.; El Kayal, W.; Torkamaneh, D.; Ayyanath, M. M.; Saxena, P. K.; Sullivan, J. A.; Paliyath, G.; Subramanian, J.
10.1101/2021.05.19.444856 — genomics — Posted on 2021-05-20
1571 SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication
Connolly, C.; Takahashi, S.; Miura, H.; Hiratani, I.; Gilbert, N.; Donaldson, A. D.; Hiraga, S.-i.
10.1101/2021.03.22.436394 — cell biology — Posted on 2021-05-20
1573 A single N6-methyladenosine site in lncRNA HOTAIR regulates its function in breast cancer cells
Porman, A. M.; Roberts, J. T.; Duncan, E. D.; Chrupcala, M. L.; Levine, A. A.; Kennedy, M. A.; Williams, M. M.; Richer, J. K.; Johnson, A. M.
10.1101/2020.06.08.140954 — molecular biology — Posted on 2021-05-20
1574 The Structure of ChAdOx1/AZD-1222 Reveals Interactions with CAR and PF4 with Implications for Vaccine-induced Immune Thrombotic Thrombocytopenia
Baker, A. T.; Boyd, R. J.; Sarkar, D.; Vant, J. W.; Teijeira-Crespo, A.; Truong, C. D.; Bates, E. A.; Wilson, E. A.; Chan, C. K.; Lipka-Lloyd, M.; Fromme, P.; Nagalo, M. B.; Heurich, M.; Williams, D.; Chiu, P.-L.; Rizkallah, P. J.; Parker, A. L.; Singharoy, A.; Borad, M. J.
10.1101/2021.05.19.444882 — molecular biology — Posted on 2021-05-20
1576 Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness
Giraud, E.; Varet, H.; Legendre, R.; Sismeiro, O.; Aubry, F.; Dabo, S.; Dickson, L. B.; Valiente Moro, C.; LAMBRECHTS, L.
10.1101/2021.05.20.444942 — microbiology — Posted on 2021-05-20
1578 Highly diverse flavobacterial phages isolated from North Sea spring blooms
Bartlau, N.; Wichels, A.; Krohne, G.; Adriaenssens, E. M.; Heins, A.; Fuchs, B. M.; Amann, R.; Moraru, C.
10.1101/2021.05.20.444936 — microbiology — Posted on 2021-05-20
1580 High resolution analysis of proteome dynamics during Bacillus subtilis sporulation
Tu, Z.; Dekker, H.; Roseboom, W.; Swarge, B.; Setlow, P.; Brul, S.; Kramer, G.
10.1101/2021.05.20.445030 — microbiology — Posted on 2021-05-20
1583 The Filter Detection Task for measurement of breathing-related interoception and metacognition
Harrison, O. K.; Garfinkel, S. N.; Marlow, L.; Finnegan, S.; Marino, S.; Nanz, L.; Allen, M.; Finnemann, J.; Keur-Huizinga, L.; Harrison, S. J.; Stephan, K. E.; Pattinson, K. T.; Fleming, S. M.
10.1101/2020.06.29.176941 — neuroscience — Posted on 2021-05-20
1584 A Developmental Reduction of the Excitation:Inhibition Ratio in Association Cortex during Adolescence.
Larsen, B.; Cui, Z.; Adebimpe, A.; Pines, A. R.; Alexander-Bloch, A.; Bertolero, M.; Calkins, M. E.; Gur, R. E.; Gur, R. C.; Mahadevan, A. S.; Moore, T. M.; Roalf, D. R.; Seidlitz, J.; Sydnor, V. J.; Wolf, D. H.; Satterthwaite, T. D.
10.1101/2021.05.19.444703 — neuroscience — Posted on 2021-05-20
1589 Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy
Vincent, M. P.; Stack, T.; Vahabikashi, A.; Li, G.; Perkumas, K. M.; Ren, R.; Gong, H.; Stamer, W. D.; Johnson, M.; Scott, E. A.
10.1101/2021.05.19.444878 — bioengineering — Posted on 2021-05-20
1590 Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans
Perez-Borrajero, C.; Podvalnaya, N.; Holleis, K.; Raffael, L.; Basquin, J.; Hennig, J.; Ketting, R. F.; Falk, S.
10.1101/2021.05.20.444926 — biochemistry — Posted on 2021-05-20
1595 Analysis of viromes and microbiomes from pig fecal samples reveals that phages and prophages are not vectors of antibiotic resistance genes
Billaud, M.; Lamy-Besnier, Q.; Lossouarn, J.; Moncaut, E.; Dion, M. B.; Moineau, S.; Traore, F.; Le Chatelier, E.; Denis, C.; Estelle, J.; Achard, C.; Zemb, O.; Petit, M.-A.
10.1101/2021.05.20.444921 — microbiology — Posted on 2021-05-20
1596 Identification of Actin Filament Interactors in Giardia lamblia
Steele-Ogus, M. C.; Johnson, R.; MacCoss, M. J.; Paredez, A. R.
10.1101/2021.05.19.444898 — microbiology — Posted on 2021-05-20
1597 Measuring nonapoptotic caspase activity with a transgenic reporter in mice
Nicholls, P.; Pack, T.; Urs, N.; Kumar, S.; Zhou, Y.; Ichim, G.; Turu, G.; Calabrese, E.; Roberts, W.; Fan, P.; Ostapchenko, V.; Guzman, M.; Beraldo, F.; Prado, V.; Prado, M.; Spasojevic, I.; Snyder, J.; Dzirasa, K.; Johnson, G. A.; Caron, M.
10.1101/196105 — neuroscience — Posted on 2021-05-20
1598 Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection
Schuhenn, J.; Meister, T. L.; Todt, D.; Bracht, T.; Schork, K.; Billaud, J.-N.; Elsner, C.; Heinen, N.; Karakoese, Z.; Haid, S.; Kumar, S.; Brunotte, L.; Eisenacher, M.; Chen, J.; Yuan, Z.; Pietschmann, T.; Wiegmann, B.; Beckert, H.; Taube, C.; Le-Trilling, V. T. K.; Trilling, M.; Krawczyk, A.; Ludwig, S.; Sitek, B.; Steinmann, E.; Dittmer, U.; Sutter, K.; Pfaender, S.
10.1101/2021.05.20.444757 — cell biology — Posted on 2021-05-20
1599 A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
Beumer, J.; Geurts, M. H.; Lamers, M. M.; Puschhof, J.; Zhang, J.; van der Vaart, J.; Mykytyn, A. Z.; Breugem, T. I.; Riesebosch, S.; Schipper, D.; van den Doel, P. B.; de Lau, W.; Pleguezuelos-Manzano, C.; Busslinger, G.; Haagmans, B. L.; Clevers, H.
10.1101/2021.05.20.444952 — molecular biology — Posted on 2021-05-20
1600 4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication
Sourimant, J.; Lieber, C.; Aggarwal, M.; Cox, R.; Wolf, J.; Yoon, J.-J.; Toots, M.; Ye, C.; Sticher, Z.; Kolykhalov, A. A.; Martinez-Sobrido, L.; Bluemling, G. R.; Natchus, M. G.; Painter, G. R.; Plemper, R. K.
10.1101/2021.05.19.444875 — microbiology — Posted on 2021-05-20
1601 Acute SARS-CoV-2 infection is associated with an expansion of bacteria pathogens in the nose including Pseudomonas aeruginosa
Rhoades, N. S.; Pinski, A.; Monsibais, A. N.; Jankeel, A.; Doratt, B. M.; Cinco, I. R.; Ibraim, I.; Messaoudi, I.
10.1101/2021.05.20.445008 — microbiology — Posted on 2021-05-20
1603 Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity
Nanishi, E.; Borriello, F.; O'Meara, T. R.; McGrath, M. E.; Saito, Y.; Haupt, R. E.; Seo, H.-S.; van Haren, S. D.; Brook, B.; Chen, J.; Diray-Arce, J.; Doss-Gollin, S.; De Leon, M.; Chew, K.; Menon, M.; Song, K.; Xu, A. Z.; Caradonna, T. M.; Feldman, J.; Hauser, B. M.; Schmidt, A. G.; Sherman, A. C.; Baden, L. R.; Ernst, R. K.; Dillen, C.; Weston, S. M.; Johnson, R. M.; Hammond, H. L.; Mayer, R.; Burke, A.; Bottazzi, M. E.; Hotez, P. J.; Strych, U.; Chang, A.; Yu, J.; Barouch, D. H.; Dhe-Paganon, S.; Zanoni, I.; Ozonoff, A.; Frieman, M.; Levy, O.; Dowling, D. J.
10.1101/2021.05.20.444848 — immunology — Posted on 2021-05-20
1604 Single-dose AAV-based vaccine induces a high level of neutralizing antibodies and provides long-term protection against SARS-CoV-2 in rhesus macaques
Tong, D.; Zhang, M.; Yang, Y.; Xia, H.; Tong, H.; Zeng, W.; Liu, M.; Ma, H.; Hu, X.; Liu, W.; Cai, Y.; Yao, Y.; Yao, Y.; Liu, K.; Shan, S.; Li, Y.; Gao, G.; Guo, W.; Peng, Y.; Chen, S.; Rao, J.; Zhao, J.; Min, J.; Zhu, Q.; Zheng, Y.; Liu, L.; Shan, C.; Zhong, K.; Qiu, Z.; Jin, T.; Yuan, Z.; Xue, T.
10.1101/2021.05.19.444881 — immunology — Posted on 2021-05-20
1605 RNA silencing by CRISPR in plants does not require Cas13
Sharma, V.; Marla, S. R.; Zheng, W.; Mishra, D.; Huang, J.; ZHANG, W.; Morris, G. P.; Cook, D.
10.1101/2021.05.20.445036 — plant biology — Posted on 2021-05-20
1606 Automatic Landmark Detection of Human Back Surface from Depth Images via Deep Learning
Delgarmi, M.; Heravi, H.; Rahimpour Jounghani, A.; Shahrezie, A.; Ebrahimi, A.; Shamsi, M.
10.1101/2021.02.04.429842 — bioengineering — Posted on 2021-05-20
1609 ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling
Asaro, A.; Sinha, R.; Bakun, M.; Kalnytska, O.; Carlo-Spiewok, A.-S.; Rubel, T.; Rozeboom, A.; Dadlez, M.; Kaminska, B.; Aronica, E.; Malik, A. R.; Willnow, T.
10.1101/2021.05.20.444938 — cell biology — Posted on 2021-05-20
1611 Development of a multi-primer metabarcoding approach to understand trophic interactions in agroecosystems
Batuecas, I.; Alomar, O.; Castañe, C.; Piñol, J.; Boyer, S.; Gallardo-Montoya, L.; Agusti, N.
10.1101/2021.05.19.444782 — ecology — Posted on 2021-05-20
1615 V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy
Hooper, K. M.; Jacquin, E.; Li, T.; Goodwin, J. M.; Brumell, J. H.; Durgan, J.; Florey, O.
10.1101/2021.05.20.444917 — cell biology — Posted on 2021-05-20
1617 Systematic Tuning of Rhodamine Spirocyclization for Super-Resolution Microscopy
Lardon, N.; Wang, L.; Tschanz, A.; Hoess, P.; Tran, M.; D'Este, E.; Ries, J.; Johnsson, K.
10.1101/2021.05.20.444797 — cell biology — Posted on 2021-05-20
1618 In vitro models of the human esophagus reveal ancestrally diverse response to injury
Ferrer-Torres, D.; Wu, J. H.; Zhang, C. J.; Hammer, M. A.; Dame, M. K.; Wu, A.; Holloway, E. M.; Karpoff, K.; McCarthy, C. L.; Bohm, M. S.; Huang, S.; Tsai, Y.-H.; Hogan, S. P.; Turgeon, D. K.; Lin, J.; Higgins, P. D.; Sexton, J.; Spence, J. R.
10.1101/2021.05.20.444920 — cell biology — Posted on 2021-05-20
1621 Neuronal mitochondria transport Pink1 mRNA via Synaptojanin 2 to support local mitophagy
Harbauer, A. B.; Wanderoy, S.; Hees, J. T.; Gibbs, W.; Ordonez, M.; Cai, Z.; Cartoni, R.; Ashrafi, G.; Wang, C.; He, Z.; Schwarz, T. L.
10.1101/2021.05.19.444778 — neuroscience — Posted on 2021-05-20
1623 Detection of Small Fiber Neuronal Activity with Optically Pumped Magnetometers
Bu, Y.; Borna, A.; Schwindt, P.; Zeng, X.; Huang, M.; Baum, E.; Rao, R.; Kimball, D.; Shah, V.; Lerman, I.
10.1101/2021.05.18.444539 — neuroscience — Posted on 2021-05-20
1625 A concurrent canonical and modified miRNAome pan-cancer study on TCGA and TARGET cohorts leads to an enhanced resolution in cancer
Distefano, R.; Tomasello, L.; Vinciguerra, G. L. R.; Gasparini, P.; Xiang, Y.; Bagnoli, M.; Marceca, G. P.; Fadda, P.; Lagana, A.; Acunzo, M.; Ma, Q.; Nigita, G.; Croce, C. M.
10.1101/2021.05.18.444694 — cancer biology — Posted on 2021-05-20
1632 Haplotype-aware inference of human chromosome abnormalities
Ariad, D.; Yan, S. M.; Victor, A. R.; Barnes, F. L.; Zouves, C. G.; Viotti, M.; McCoy, R. C.
10.1101/2021.05.18.444721 — genomics — Posted on 2021-05-20
1634 Gene flow influences the genomic architecture of local adaptation in six riverine fish species
Shi, Y.; Bouska, K. L.; McKinney, G. J.; Dokai, W.; Bartels, A.; McPhee, M. V.; Larson, W. A.
10.1101/2021.05.18.444736 — evolutionary biology — Posted on 2021-05-20
1637 CARDIOVASCULAR AUTONOMIC NEUROPATHY IN TYPE 1 DIABETES IS ASSOCIATED WITH SEVERAL METABOLIC PATHWAYS: New Risk Markers on the horizon
Hansen, C. S.; Suvitaival, T. S.; Theilade, S.; Mattila, I.; Lajer, M.; Trost, K.; Ahonen, L.; Hansen, T. W.; Legido-Quigley, C.; Rossing, P.; Ahluwalia, T. S.
10.1101/2021.05.18.444673 — neuroscience — Posted on 2021-05-20
1641 A Model for Self-Organization of Sensorimotor Function: The Spinal Monosynaptic Loop
Enander, J. M. D.; Loeb, G. E.; Jorntell, H.; Jones, A. M.; Kirkland, M.; Hurless, J.
10.1101/2021.05.18.444712 — neuroscience — Posted on 2021-05-20
1643 Deceleration of cell cycle underpins a switch from proliferative- to terminal division in plant stomatal lineage
Han, S.-K.; Yang, J.; Arakawa, M.; Iwasaki, R.; Sakamoto, T.; Kimura, S.; Kim, E.-D.; Torii, K. U.
10.1101/2021.05.17.442671 — plant biology — Posted on 2021-05-20
1644 Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift
Gay, L.; Dhinaut, J.; Jullien, M.; Vitalis, R.; Navascues, M.; Ranwez, V.; Ronfort, J.
10.1101/2020.08.21.261230 — evolutionary biology — Posted on 2021-05-20
1646 β-RA targets mitochondrial metabolism and adipogenesis, leading to therapeutic benefits against CoQ deficiency and age-related overweight
Hidalgo-Gutierrez, A.; Barriocanal-Casado, E.; Diaz-Casado, M. E.; Gonzalez-Garcia, P.; Zenezini Chiozzi, R.; Acuna-Castroviejo, D.; Lopez, L. C.
10.1101/2021.04.13.438670 — physiology — Posted on 2021-05-20
1648 A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)
Brown, A. R.; Comai, K.; Mannino, D.; McCullough, H.; Meyers, H. C.; Donekal, Y.; The BIO306 Consortium, ; Graves, C. W.; Seidel, H. S.
10.1101/2021.05.19.444867 — genetics — Posted on 2021-05-20
1650 NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylation
Dominguez, F.; Shiliaev, N.; Lukash, T.; Agback, P.; Palchevska, O.; Gould, J. R.; Meshram, C. D.; Prevelige, P. E.; Green, T. J.; Agback, T.; Frolova, E. I.; Frolov, I.
10.1101/2021.05.19.444900 — microbiology — Posted on 2021-05-20
1652 Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
Formiga, R. O.; Amaral, F. C.; Souza, C. F.; Mendes, D. A. G. B.; Wanderley, C. W. S.; Lorenzini, C. B.; Santos, A. A.; Antonia, J.; Faria, L. F.; Natale, C. C.; Paula, N. M.; Silva, P. C. S.; Fonseca, F. R.; Aires, L.; Heck, N.; Starick, M. R.; Barroso, S. P. C.; Morrot, A.; Van Weyenbergh, J.; Sordi, R.; Alisson-Silva, F.; Mansur, D. S.; Cunha, F. Q.; Lummertz da Rocha, E.; Witko-Sarsat, V.; Burgel, P.-R.; Martin, C.; Maurici, R.; Bafica, A.; Macauley, M. S.; Spiller, F.
10.1101/2020.11.12.379115 — immunology — Posted on 2021-05-20
1653 Cooperation of two opposite flagella allows high-speed swimming and active turning in zoospores
Tran, Q. D.; Galiana, E.; Thomen, P.; Cohen, C.; Orange, F.; Peruani, F.; Noblin, X.
10.1101/2021.04.23.441092 — biophysics — Posted on 2021-05-20
1654 Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication
Malla, T. N.; Pandey, S.; Aldama, L.; Feliz, D.; Noda, M.; Poudyal, I.; Phillips, G. N.; Stojkovic, E. A.; Schmidt, M.
10.1101/2021.05.02.442358 — biophysics — Posted on 2021-05-20
1658 A coarse-grained approach to model the dynamics of the actomyosin cortex
Hernandez-del-valle, M.; Valencia-Exposito, A.; Lopez-Izquierdo, A.; casanova ferrer, p.; Tarazona, P.; Martin-Bermudo, M. D.; Miguez, d. G.
10.1101/2021.05.20.444937 — biophysics — Posted on 2021-05-20
1659 Protein detection in blood with single-molecule imaging
Mao, C.-P.; Wang, S.-C.; Su, Y.-P.; Tseng, S.-H.; He, L.; Wu, A.; Xiao, J.; Roden, R.; Hung, C.-F.
10.1101/2021.05.19.444873 — biophysics — Posted on 2021-05-20
1660 UMGAP: the Unipept MetaGenomics Analysis Pipeline
Van der Jeugt, F.; Maertens, R.; Steyaert, A.; Verschaffelt, P.; De Tender, C.; Dawyndt, P.; Mesuere, B.
10.1101/2021.05.18.444604 — bioinformatics — Posted on 2021-05-20
1664 Cell-specific imputation of drug connectivity mapping with incomplete data
Sapashnik, D.; Newman, R.; Pietras, C. M.; Qu, F.; Kofman, L.; Boudreau, S.; Fried, I.; Slonim, D.
10.1101/2020.08.10.231720 — bioinformatics — Posted on 2021-05-20
1668 Light-weight Electrophysiology Hardware and Software Platform for Cloud-Based Neural Recording Experiments
Voituik, K.; Geng, J.; Keefe, M. G.; Parks, D. F.; Sanso, S. E.; Hawthorne, N.; Freeman, D. B.; Nowakowski, T. J.; Salama, S. R.; Teodorescu, M.; Haussler, D.
10.1101/2021.05.18.444685 — bioengineering — Posted on 2021-05-20
1671 Decoding silence in free recall
Fumarola, F.; He, Z.; Kusmierz, Łukasz; Toyoizumi, T.
10.1101/2021.01.26.428351 — animal behavior and cognition — Posted on 2021-05-20
1675 The Psychometrics of Automatic Speech Recognition
Weerts, L.; Rosen, S.; Clopath, C.; Goodman, D. F. M.
10.1101/2021.04.19.440438 — neuroscience — Posted on 2021-05-20
1677 Trait-based responses to land use and canopy dynamics modify long-term diversity changes in forest understories
Happonen, K.; Muurinen, L.; Virtanen, R.; Kaakinen, E.; Grytnes, J.-A.; Kaarlejärvi, E.; Parisot, P.; Wolff, M.; Maliniemi, T.
10.1101/2020.04.30.069708 — ecology — Posted on 2021-05-20
1679 Dendritic spines are lost in clusters in Alzheimers disease
Mijalkov, M.; Volpe, G.; Fernaud-Espinosa, I.; DeFelipe, J.; B. Pereira, J.; Merino-Serrais, P.
10.1101/2020.10.20.346718 — neuroscience — Posted on 2021-05-20
1680 The FusX TALE Base Editor (FusXTBE) for rapid mitochondrial DNA programming of human cells in vitro and zebrafish disease models in vivo
Sabharwal, A.; Kar, B.; Castillo, S. R.; Holmberg, S. R.; Kendall, B. L.; Cotter, R. P.; WareJoncas, Z.; Clark, K. J.; Ekker, S. C.
10.1101/2021.05.18.444740 — genetics — Posted on 2021-05-20
1681 A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug response
Gambardella, G.; Viscido, G.; Tumaini, B.; Isacchi, A.; Bosotti, R.; di Bernardo, D.
10.1101/2021.03.02.433590 — bioinformatics — Posted on 2021-05-20
1682 Normalization benchmark of ATAC-seq datasets shows the importance of accounting for GC-content effects
Van den Berge, K.; Chou, H.-J.; Roux de Bezieux, H.; Street, K.; Risso, D.; Ngai, J.; Dudoit, S.
10.1101/2021.01.26.428252 — bioinformatics — Posted on 2021-05-20
1685 Multi-Tissue Multi-Compartment models of diffusion MRI
Frigo, M.; Fick, R. H. J.; Zucchelli, M.; Deslauriers-Gauthier, S.; Deriche, R.
10.1101/2021.01.29.428843 — neuroscience — Posted on 2021-05-20
1686 SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues
Bühler, M. M.; Lu, J.; Scheinost, S.; Nadeu, F.; Roos-Weil, D.; Hensel, M.; Thavayogarajah, T.; Moch, H.; Manz, M. G.; Haralambieva, E.; Marques Maggio, E.; Bea, S.; Gine, E.; Campo, E.; Bernard, O. A.; Huber, W.; Zenz, T.
10.1101/2020.06.09.140376 — cancer biology — Posted on 2021-05-20
1688 Colonial choanoflagellate isolated from Mono Lake harbors a microbiome
Hake, K.; West, P. T.; McDonald, K. L.; Laundon, D.; Garcia De Las Bayonas, A.; Feng, C.; Burkhardt, P.; Richter, D. J.; Banfield, J.; King, N.
10.1101/2021.03.30.437421 — microbiology — Posted on 2021-05-20
1689 Soils and sediments host novel archaea with divergent monooxygenases implicated in ammonia oxidation
Diamond, S.; Lavy, A.; Crits-Christoph, A.; Matheus Carnevali, P. B.; Sharrar, A.; Williams, K. H.; Banfield, J. F.
10.1101/2021.05.03.442362 — microbiology — Posted on 2021-05-20
1690 A GenoChemetic strategy for derivatization of the violacein natural product scaffold
Lai, H.-E.; Obled, A. M.; Chee, S. M.; Morgan, R. M.; Lynch, R.; Sharma, S. V.; Moore, S. J.; Polizzi, K. M.; Goss, R. J.; Freemont, P. S.
10.1101/202523 — synthetic biology — Posted on 2021-05-20
1691 Enhancement of CRISPR-mediated homologous recombination-based gene knock-in efficiency by simultaneous HDR overexpression and NHEJ suppression in poplar
Movahedi, A.; Wei, H.; Zhou, X.; C. Fountain, J.; Chen, Z.-H.; Mu, Z.; Sun, W.; Zhang, J.; Li, D.; Guo, B.; K. Varshney, R.; Yang, L.; Zhuge, Q.
10.1101/2020.07.04.188219 — plant biology — Posted on 2021-05-20
1693 Intracellular Ca2+ channels initiate physiological glucose signaling in beta cells examined in situ
Postic, S.; Sarikas, S.; Pfabe, J.; Pohorec, V.; Krizancic Bombek, L.; Sluga, N.; Skelin Klemen, M.; Dolensek, J.; Korosak, D.; Stozer, A.; Evans-Molina, C.; Johnson, J. D.; Slak Rupnik, M.
10.1101/2021.04.14.439796 — physiology — Posted on 2021-05-20
1695 Progressive Increases in Mesenchymal Cell Diversity Modulate Lung Development and are Attenuated by Hyperoxia
Zanini, F.; Che, X.; Suresh, N.; Knutsen, C.; Klavina, P.; Xie, Y.; Domingo-Gonzales, R.; Jones, R. C.; Quake, S. R.; Alvira, C. M.; Cornfield, D. N.
10.1101/2021.05.19.444776 — developmental biology — Posted on 2021-05-20
1697 Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
Garcia, I.; Munoz, S.; Chymkowitch, P.; Papamichos-Chronakis, M.; Andersen, A. N.; Zimmermann, C.; Eriksson, J.; Enserink, J.
10.1101/2021.05.19.443414 — cell biology — Posted on 2021-05-20
1698 Anomalous propulsion regime in axonemal-propelled cargoes
Ahmad, R.; Bae, A. J.; Su, Y.-J.; Pozveh, S. G.; Pumir, A.; Bodenschatz, E.; Gholami, A.
10.1101/2021.05.19.444861 — biophysics — Posted on 2021-05-20
1701 A Modular Platform for Streamlining Automated Cryo-FIB Workflows
Klumpe, S.; Fung, H. K. H.; Goetz, S. K.; Zagoriy, I.; Hampoelz, B.; Zhang, X.; Erdmann, P. S.; Baumbach, J.; Mueller, C. W.; Beck, M.; Plitzko, J. M.; Mahamid, J.
10.1101/2021.05.19.444745 — biophysics — Posted on 2021-05-20
1706 A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
Li, S.; Yan, R.; Xu, J.; Zhao, S.; Ma, X.; Sun, Q.; Zhang, M.; Li, Y.; Liu, J.-J. G.; Chen, L.; Li, S.; Xu, K.; Ge, L.
10.1101/2021.05.19.444771 — cell biology — Posted on 2021-05-19
1707 The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering non-imported proteins
Knoeringer, K.; Groh, C.; Kraemer, L.; Stein, K. C.; Hansen, K. G.; Herrmann, J. M.; Frydman, J.; Boos, F.
10.1101/2021.05.19.444788 — cell biology — Posted on 2021-05-20
1708 Mitochondria serve as axonal shuttle for Cox7c mRNA through mechanism that involves its mitochondrial targeting signal
Cohen, B.; Golani-Armon, A.; Altman, T.; Savulescu, A. F.; Mhlanga, M. M.; Perlson, E.; Arava, Y. S.
10.1101/2021.05.19.444640 — cell biology — Posted on 2021-05-20
1710 Linguistic laws are not the law in chimpanzee sexual solicitation gestures.
Safryghin, A.; Cross, C. P.; Fallon, B.; Heesen, R.; Ferrer-i-Cancho, R.; Hobaiter, C.
10.1101/2021.05.19.444810 — animal behavior and cognition — Posted on 2021-05-19
1711 Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa
Atkinson, E. G.; Dalvie, S.; Pichkar, Y.; Kalungi, A.; Majara, L.; Stevenson, A.; Abebe, T.; Akena, D.; Alemayehu, M.; Ashaba, F. K.; Atwoli, L.; Baker, M.; Chibnik, L. B.; Creanza, N.; Daly, M. J.; Fekadu, A.; Gelaye, B.; Gichuru, S.; Injera, W. E.; James, R.; Kariuki, S. M.; Kigen, G.; Koen, N.; Koenen, K. C.; Koenig, Z.; Kwobah, E.; Kyebuzibwa, J.; Musinguzi, H.; Mwema, R. M.; Neale, B. M.; Newman, C. P.; Newton, C. R. J. C.; Ongeri, L.; Ramachandran, S.; Ramesar, R.; Shiferaw, W.; Stein, D. J.; Stroud, R. E.; Teferra, S.; Zingela, Z.; Martin, A. R.; NeuroGAP-Psychosis Study Team,
10.1101/2021.05.19.444732 — genomics — Posted on 2021-05-19
1713 Concurrent invasions by European starlings (Sturnus vulgaris) suggest selection on shared genomic regions even after genetic bottlenecks
Hofmeister, N. R.; Stuart, K.; Warren, W. C.; Werner, S. J.; Bateson, M.; Ball, G. F.; Buchanan, K. L.; Burt, D. W.; Cardilini, A. P.; Cassey, P.; De Meyer, T.; George, J.; Meddle, S. L.; Rowland, H. M.; Sherman, C. D. H.; Sherwin, W. B.; Van Den Berghe, W.; Rollins, L. A.; Clayton, D. F.
10.1101/2021.05.19.442026 — evolutionary biology — Posted on 2021-05-19
1714 A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain
Pornnoppadol, G.; Zhang, B.; Desai, A. A.; Berardi, A.; Remmer, H. A.; Tessier, P. M.; Greineder, C. F.
10.1101/2021.05.19.444780 — molecular biology — Posted on 2021-05-19
1715 The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
Ajouaou, Y.; Azouz, A.; Taquin, A.; Hussein, H.; Andris, F.; Moser, M.; Goriely, S.; Leo, O.
10.1101/2021.03.23.436597 — immunology — Posted on 2021-05-19
1716 Perineuronal nets in HVC and plasticity in male canary song
Cornez, G.; Valle, S.; dos Santos, E. B.; Chiver, I.; Müller, W.; Ball, G. F.; Cornil, C. A.; Balthazart, J.
10.1101/2021.05.19.444779 — neuroscience — Posted on 2021-05-19
1718 Corticotropin-Releasing Factor Induces Functional And Structural Synaptic Remodelling In Acute Stress
Vandael, D.; Wierda, K.; Vints, K.; Baatsen, P.; De Groef, L.; Moons, L.; Rybakin, V.; Gounko, N. V.
10.1101/2021.05.19.443320 — neuroscience — Posted on 2021-05-19
1724 RBPMS2 is a conserved regulator of alternative splicing that promotes myofibrillar organization and optimal calcium handling in cardiomyocytes
Akerberg, A. A.; Trembley, M.; Butty, V.; Schwertner, A.; Zhao, L.; Beerens, M.; Liu, X.; Mahamdeh, M.; Yuan, S.; Boyer, L.; MacRae, C.; Nguyen, C.; Pu, W. T.; Burns, C. E.; Burns, C. G.
10.1101/2021.03.08.434502 — developmental biology — Posted on 2021-05-19
1725 The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice lightsheet microscopy
Quinn, S. E.; Huang, L.; Kerkvliet, J. G.; Swanson, J. A.; Smith, S.; Hoppe, A. D.; Anderson, R. B.; Thiex, N. W.; Scott, B. L.
10.1101/2020.12.01.390195 — cell biology — Posted on 2021-05-19
1726 Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts
Suryawanshi, H.; Yang, H.; Lubetzky, M.; Morozov, P.; Lagman, M.; Alonso, A.; Li, C.; Snopkowski, C.; Mueller, F.; Lee, J.; Dadhania, D.; Salvatore, S.; Seshan, S.; Sharma, V.; Suthanthiran, M.; Tuschl, T.; Muthukumar, T.
10.1101/2020.09.03.281733 — molecular biology — Posted on 2021-05-19
1727 Tafazzin regulates the function of lipopolysaccharide activated B lymphocytes in mice
Zegallai, H. M.; Abu-El-Rub, E.; Cole, L. K.; Field, J.; Mejia, E. M.; Gordon, J. W.; Marshall, A. J.; Hatch, G. M.
10.1101/2021.05.17.444507 — immunology — Posted on 2021-05-19
1728 The AP-1 factors FOSL1 and FOSL2 co-regulate human Th17 responses
Shetty, A.; Tripathi, S. K.; Junttila, S.; Buchacher, T.; Biradar, R.; Bhosale, S. D.; Envall, T.; Laiho, A.; Moulder, R.; Rasool, O.; Galande, S.; Elo, L. L.; Lahesmaa, R.
10.1101/2021.04.26.441472 — immunology — Posted on 2021-05-19
1729 Less is more: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain
Martins, D.; Brodmann, K.; Veronese, M.; Dipasquale, O.; Mazibuko, N.; Schuschnig, U.; Zelaya, F.; Fotopoulou, K.; Paloyelis, Y.
10.1101/2021.01.18.427062 — neuroscience — Posted on 2021-05-19
1732 RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.
Naszai, M.; Bellec, K.; Yu, Y.; Roman Fernandez, A.; Sandilands, E.; Johansson, J.; Campbell, A. D.; Norman, J. C.; Sansom, O. J.; Bryant, D.; Cordero, J. B.
10.1101/2020.10.07.329607 — cancer biology — Posted on 2021-05-19
1733 DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation
Liu, Y.; Rosikiewicz, W.; Pan, Z.; Jillette, N.; Wang, P.; Taghbalout, A.; Foox, J.; Mason, C.; Carroll, M.; Cheng, A.; Li, S.
10.1101/2021.05.05.442849 — bioinformatics — Posted on 2021-05-19
1735 Effect of reduced graphene oxide (rGO) compaction degree and concentration on rGO-polymer composites printability and cell interactions
Camara Torres, M.; Sinha, R.; Eqtesadi, S.; Wendelbo, R.; Scatto, M.; Scopece, P.; Sanchez, A.; Villanueva, S.; Egizabal, A.; Alvarez, N.; Patelli, A.; Mota, C.; Moroni, L.
10.1101/2021.05.18.444680 — bioengineering — Posted on 2021-05-19
1737 Genetic basis of growth, phenology and susceptibility to biotic stressors in maritime pine
Hurel, A.; de Miguel, M.; Dutech, C.; Desprez-Loustau, M.-L.; Plomion, C.; Rodriguez-Quilon, I.; Cyrille, A.; Guzman, T.; Alia, R.; Gonzalez-Martinez, S. C.; Budde, K. B.
10.1101/699389 — genetics — Posted on 2021-05-19
1740 Adaptive actin organization buffers endocytosis against changes in membrane tension
Kaplan, C.; Kenny, S. J.; Chen, S.; Schoeneberg, J.; Sitarska, E.; Diz-Munoz, A.; Akamatsu, M.; Xu, K.; Drubin, D. G.
10.1101/2020.04.05.026559 — cell biology — Posted on 2021-05-19
1742 The microbiome of Lotus nodules varies with plant health in a species-specific manner
Crosbie, D. B.; Mahmmoudi, M.; Radl, V.; Brachmann, A.; Schloter, M.; Kemen, E.; Marin, M.
10.1101/2021.05.19.441130 — microbiology — Posted on 2021-05-19
1748 Modulation of fracture healing by the transient accumulation of senescent cells
Khosla, S.; Saul, D.; Monroe, D.; Rowsey, J. L.; Kosinsky, R. L.; Vos, S. J.; Doolittle, M. L.; Farr, J. N.
10.1101/2021.05.18.444618 — physiology — Posted on 2021-05-19
1749 Loss of intestinal ChREBP impairs absorption of dietary sugars and prevents glycemic excursion curves
Charifi, W.; Fauveau, V.; Francese, L.; Grosfeld, A.; Le Gall, M.; Ourabah, S.; Ellero-Simantos, S.; Viel, T.; Cauzac, M.; Gueddouri, D.; Benhamed, F.; Tavitian, B.; Dentin, R.; Burnol, A.-F.; Postic, C.; Guilmeau, S.
10.1101/2021.05.18.444615 — physiology — Posted on 2021-05-19
1750 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity
Mobbs, J.; Belousoff, M. J.; Harikumar, K. G.; Piper, S. J.; Xu, X.; Furness, S. G. B.; Venugopal, H.; Christopoulos, A.; Danev, R.; Wootten, D.; Thal, D. M.; Miller, L. J.; Sexton, P. M.
10.1101/2021.05.06.442871 — pharmacology and toxicology — Posted on 2021-05-19
1751 PodoCount: A robust, fully automated whole-slide podocyte quantification tool
Santo, B. A.; Govind, D.; Daneshpajouhnejad, P.; Yang, X.; Wang, X. X.; Myakala, K.; Jones, B. A.; Levi, M.; Kopp, J. B.; Niedernhofer, L. J.; Manthey, D.; Moon, K. C.; Han, S. S.; Rosenberg, A. Z.; Sarder, P.
10.1101/2021.04.27.441689 — pathology — Posted on 2021-05-19
1755 Fuscimiditide: a RiPP with {Omega}-Ester and Aspartimide Post-translational Modifications
Elashal, H. E.; Koos, J. D.; Cheung-Lee, W. L.; Choi, B.; Cao, L.; Richardson, M. A.; White, H. L.; Link, A. J.
10.1101/2021.05.19.444834 — biochemistry — Posted on 2021-05-19
1759 RNA interference mediates RNA toxicity with parent-of-origin effects in C. elegans expressing CTG repeats
Braun, M.; Shoshani, S.; Teixeira, J.; Mellul-Shtern, A.; Miller, M.; Granot, Z.; Fischer, S.; Garcia, S. M. D. A.; Tabach, Y.
10.1101/2021.05.19.444826 — molecular biology — Posted on 2021-05-19
1760 PiggyBac Transposable Element-derived 1 controls Neuronal Progenitor Identity, Stress Sensing and mammal-specific paraspeckles
Rasko, T.; Pande, A.; Radscheit, K.; Zink, A.; Singh, M.; Sommer, C.; Szvetnik, A.; Bunse, M.; Selbach, M.; Wachtl, G.; Kolacsek, O.; Inak, G.; Petrakis, S.; Bansal, V.; Orban, T.; Prigione, A.; Hurst, L. D.; Izsvak, Z.
10.1101/2021.05.19.444448 — molecular biology — Posted on 2021-05-19
1763 Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis
Slonchak, A.; Wang, X.; Chaggar, H.; Aguado, J.; Freney, M.; Yan, K.; Torres, F. J.; Amarilla, A. A.; Balea, R.; Sng, J. D. J.; Setoh, Y. X.; Peng, N.; Watterson, D.; Wolvetang, E.; Suhrbier, A.; Khromykh, A. A.
10.1101/2021.05.18.444753 — microbiology — Posted on 2021-05-19
1765 Global Patterns in Culturable Soil Yeast Diversity
Samarasinghe, H.; Lu, Y.; Aljohani, R.; Al-Amad, A.; Yoell, H.; Xu, J.
10.1101/2021.05.19.444851 — microbiology — Posted on 2021-05-19
1767 c-di-AMP is essential for the virulence of Enterococcus faecalis
Kundra, S.; Lam, L. N.; Kajfasz, J. K.; Casella, L.; Andersen, M. J.; Abranches, J.; Flores-Mireles, A.; Lemos, J. A.
10.1101/2021.05.19.444760 — microbiology — Posted on 2021-05-19
1768 Microbial phylogenetic relatedness links to distinct successional patterns of bacterial and fungal communities
Lin, Q.; Dini-Andreote, F.; Meador, T. B.; Angel, R.; Meszarosov, L.; Hedenec, P.; Li, L.; Baldrian, P.; Frouz, J.
10.1101/2021.05.19.444715 — microbiology — Posted on 2021-05-19
1770 Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
Palomer, E.; Martin-Flores, N.; Jolly, S.; Pascual-Vargas, P.; Benvegnu, S.; Podpolny, M.; Vaher, K.; Saito, T.; Sado, T. C.; Whiting, P.; Salinas, P. C.
10.1101/2021.05.19.444683 — neuroscience — Posted on 2021-05-19
1771 Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat
Magnuson, D. S.; Shepard, C. T.; Pocratsky, A. M.; Brown, B. L.; Van Rijswijck, M. A.; Zalla, R. M.; Burke, D. A.; Morehouse, J. R.; Reigler, A. S.; Whittemore, S. R.
10.1101/2021.05.18.444653 — neuroscience — Posted on 2021-05-19
1774 Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification
Cao, L.; Beiser, M.; Koos, J. D.; Orlova, M.; Elashal, H. E.; Schroeder, H. V.; Link, A. J.
10.1101/2021.05.19.444711 — biochemistry — Posted on 2021-05-19
1776 Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution
Borges, V.; Alves, M. J.; Amicone, M.; Isidro, J.; Ze-Ze, L.; Duarte, S.; Vieira, L.; Guiomar, R.; Gomes, J. P.; Gordo, I.
10.1101/2021.05.19.444774 — evolutionary biology — Posted on 2021-05-19
1777 Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses
Rebendenne, A.; Roy, P.; Bonaventure, B.; Chaves Valadao, A. L.; Desmarets, L.; Rouille, Y.; Tauziet, M.; Arnaud-Arnould, M.; Giovanni, D.; Lee, Y.; DeWeirdt, P.; Hegde, M.; Garcia de Gracia, F.; McKellar, J.; Wencker, M.; Dubuisson, J.; Belouzard, S.; Moncorge, O.; Doench, J. G.; Goujon, C.
10.1101/2021.05.19.444823 — microbiology — Posted on 2021-05-19
1778 Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2
Israelow, B.; Mao, T.; Klein, J.; Song, E.; Menasche, B.; Omer, S. B.; Iwasaki, A.
10.1101/2021.05.19.444825 — immunology — Posted on 2021-05-19
1779 Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection
Moses, M. E.; Hofmeyr, S.; Cannon, J. L.; Andrews, A.; Gridley, R.; Hinga, M.; Leyba, K.; Pribisova, A.; Surdidijaja, V.; Tasnim, H.; Forrest, S.
10.1101/2021.05.19.444569 — immunology — Posted on 2021-05-19
1780 Peptide Ancestry Informative Markers in Uterine Neoplasms from Women of European, African and Asian Ancestry
Bateman, N. W.; Tarney, C. M.; Abulez, T. S.; Hood, B. L.; Conrads, K. A.; Zhou, M.; Soltis, A. R.; Teng, P.-i.; Jackson, A.; Tian, C.; Dalgard, C. L.; Wilkerson, M. D.; Kessler, M. D.; Goecker, Z. C.; Loffredo, J.; Shriver, C. D.; Hu, H.; Cote, M.; Parker, G. J.; Segars, J.; Al-Hendy, A.; Risinger, J. R.; Darcy, K. M.; Casablanca, Y.; Maxwell, G. L.; Conrads, T. P.; O'Connor, T. D.
10.1101/2020.11.23.380337 — cancer biology — Posted on 2021-05-19
1782 A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain "Silveira"
de M. Teixeira, M. M.; Stajich, J. E.; Sahl, J. W.; Thompson, G. R.; Mead, H. L.; Blackmon, A. V.; Keim, P.; Barker, B. M.
10.1101/2021.05.19.444813 — genomics — Posted on 2021-05-19
1784 Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA Vaccination
Ramiro de Assis, R.; Jain, A.; Nakajima, R.; Jasinskas, A.; Khan, S.; Palma, A.; Parker, D. M.; Chau, A.; Leung, A.; Grabar, C.; Muqolli, F.; Khalil, G.; Colin Escobar, J.; Ventura, J.; Davies, H.; Albala, B.; Boden-Albala, B.; Schubl, S.; Felgner, P. L.
10.1101/2021.04.15.440089 — immunology — Posted on 2021-05-19
1786 RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.
Naszai, M.; Bellec, K.; Yu, Y.; Roman Fernandez, A.; Sandilands, E.; Johansson, J.; Norman, J. C.; Campbell, A. D.; Sansom, O. J.; Bryant, D.; Cordero, J. B.
10.1101/2020.10.07.329607 — cancer biology — Posted on 2021-05-19
1787 TWIST1 expression is associated with high-risk Neuroblastoma and promotes Primary and Metastatic Tumor Growth
Sepporta, M.-V.; Praz, V.; Balmas Bourloud, K.; Joseph, J.-M.; Jauquier, N.; Riggi, N.; Nardou-Auderset, K.; Petit, A.; Scoazec, J.-Y.; Sartelet, H.; Renella, R.; Muhlethaler-Mottet, A.
10.1101/2021.03.22.435811 — cancer biology — Posted on 2021-05-19
1789 Fast holographic scattering compensation for deep tissue biologicalimaging
May, M. A.; Barre;, N.; Kummer, K.; Kress, M.; Ritsch-Marte, M.; Jesacher, A.
10.1101/2021.03.16.435380 — biophysics — Posted on 2021-05-19
1791 Protein homeostasis imprinting across evolution
Koutsandreas, T.; Felden, B.; Chevet, E.; Chatziioannou, A.
10.1101/2020.07.19.210591 — bioinformatics — Posted on 2021-05-19
1794 DreamAI: algorithm for the imputation of proteomics data
ma, w.; Kim, S.; Chowdhury, S.; li, z.; YANG, M.; Yoo, S.; Petralia, F.; Jacobsen, J.; Li, J. J.; Ge, X.; Li, K.; Yu, T.; Calinawan, A. P.; Edwards, N. J.; Payne, S. H.; Boutros, P. C.; Rodriguez, H.; Stolovitzky, G. A.; Kang, J.; Fenyo, D.; Saez, J.; Wang, P.
10.1101/2020.07.21.214205 — bioinformatics — Posted on 2021-05-19
1795 Genetics of phosphorus use efficiency in a MAGIC wheat population grown in the field
Wasson, A. P.; Zwart, A. B.; Verbyla, A. P.; Permalloo, G.; Weligama, C.; Ryan, P. R.; Delhaize, E.
10.1101/2020.08.27.271205 — plant biology — Posted on 2021-05-19
1797 Humanized substitutions of Vmat1 in mice induce changes in amygdala-dependent behaviors associated with the evolution of anxiety in humans
Sato, D. X.; Inoue, Y. U.; Morimoto, Y.; Inoue, T.; Kuga, N.; Sasaki, T.; Ikegaya, Y.; Nomoto, K.; Kikusui, T.; Hattori, S.; Sala, G.; Hagihara, H.; Miyakawa, T.; Kawata, M.
10.1101/2021.05.18.444749 — evolutionary biology — Posted on 2021-05-19
1803 Deletion of Rap-Phr systems in Bacillus subtilis influences in vitro biofilm formation and plant root colonization
Nordgaard Christensen, M.; Mortensen, R. M. R.; Kirk, N. K.; Gallegos-Monterrosa, R.; Kovacs, A. T.
10.1101/2021.03.15.435437 — microbiology — Posted on 2021-05-19
1808 N2O-respiring bacteria in biogas digestates for reduced agricultural emissions
Jonassen, K. R.; Hagen, L. H.; Vick, S.; Arntzen, M.; Eijsink, V. G. H.; Frostegard, A.; Lycus, P.; Molstad, L.; Pope, P.; Bakken, L. R.
10.1101/2020.11.16.384990 — microbiology — Posted on 2021-05-19
1810 Deconstructing the Cortical Sources of Frequency Following Responses to Speech: A Cross-species Approach
Gnanateja, G. N.; Llanos, F.; Rupp, K.; Remick, M.; Pernia, M.; Sadagopan, S.; Teichert, T.; Abel, T.; Chandrasekaran, B.
10.1101/2021.05.17.444462 — neuroscience — Posted on 2021-05-18
1812 Dependable Algorithm for Visualizing Snoring Duration through Acoustic Analysis
Kao, H.-H.; Lin, Y.-C.; Kao, Y.-H.; Ho, M.; Yu, H.-C.; Wang, C.-L.; Chiang, J.-K.
10.1101/2021.05.18.444630 — physiology — Posted on 2021-05-18
1816 Quantitative reverse transcription PCR assay to detect pyrethroid resistance in Culex mosquitoes
Hager, K.; Gaona, E.; Kistler, A.; Ratnasiri, K.; Retallack, H.; Barretto, M.; Wheeler, S.; Hoover, C. M.; Haas-Stapleton, E. J.
10.1101/2021.05.18.444631 — ecology — Posted on 2021-05-18
1817 Highly basic clusters in the HSV-1 nuclear egress complex drive membrane budding by inducing lipid ordering
Thorsen, M. K.; Lai, A.; Lee, M. W.; Hoogerheide, D. P.; Wong, G. C. L.; Freed, J. H.; Heldwein, E. E.
10.1101/2021.05.18.444627 — microbiology — Posted on 2021-05-18
1819 Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases
Kaduri, M.; Sela, M.; Kagan, S.; Poley, M.; Abumanhal-Masarweh, H.; Mora-Raimundo, P.; Ouro, A.; Dahan, N.; Shklover, J.; Shainsky-Roitman, J.; Buganim, Y.; Schroeder, A.
10.1101/2021.05.18.444598 — cancer biology — Posted on 2021-05-18
1820 An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite
van Groningen, T.; Niklasson, C. U.; Chan, A.; Akogul, N.; Westerhout, E. M.; von Stedingk, K.; Hamdi, M.; Valentijn, L. J.; Mohlin, S.; Stroeken, P.; Hasselt, N. E.; Haneveld, F.; Lakeman, A.; Zwijnenburg, D. A.; van Sluis, P.; Bexell, D.; Adameyko, I.; Jansky, S.; Westermann, F.; Wigerup, C.; Pahlman, S.; Koster, J.; Versteeg, R.; van Nes, J.
10.1101/2021.05.18.444639 — cancer biology — Posted on 2021-05-18
1821 Inhibiting BCKDK in triple-negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity
Biswas, D.; Slade, L.; Duffley, L.; Mueller, N.; Dao, K. T.; Mercer, A.; Pakkiriswami, S.; El-Hiani, Y.; Kieneseberger, P.; Pulinilkunnil, T.
10.1101/2021.05.18.444634 — cancer biology — Posted on 2021-05-18
1822 Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC
Silberberg, J. M.; Corey, R. A.; Hielkema, L.; Stock, C.; Stansfeld, P. J.; Paulino, C.; Haenelt, I.
10.1101/2021.05.18.444724 — biophysics — Posted on 2021-05-18
1823 Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III
Di Trani, J.; Liu, Z.; Whitesell, L.; Brzezinski, P.; Cowen, L.; Rubinstein, J. L.
10.1101/2021.05.18.444650 — biochemistry — Posted on 2021-05-18
1824 3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
Himadewi, P.; Wang, X. Q. D.; Feng, F.; Gore, H.; Liu, Y.; Yu, L.; Liu, J.; Kurita, R.; Nakamura, Y.; Pfeifer, G. P.; Zhang, X.
10.1101/2021.05.18.444713 — genomics — Posted on 2021-05-18
1826 Set4 coordinates the activity of histone deacetylases and regulates stress-responsive gene expression within subtelomeric regions in yeast
Jethmalani, Y.; Tran, K.; Jaiswal, D.; Jezek, M.; Ramos, M.; Amos, S.; Garcia, E. J.; Negesse, M. Y.; Sun, W.; Park, D.; Green, E. M.
10.1101/2021.05.11.443697 — genetics — Posted on 2021-05-18
1827 Genetic signatures of divergent selection in European beech (Fagus sylvatica L.) are associated with the variation in temperature and precipitation across its distribution range
Postolache, D.; ODDOU-MURATORIO, S.; Vajana, E.; Bagnoli, F.; Guichoux, E.; Hampe, A.; Le Provost, G.; Lesur, I.; Popescu, F.; Scotti, I.; Piotti, A.; Vendramin, G. G.
10.1101/2021.05.18.444720 — evolutionary biology — Posted on 2021-05-18
1828 Hybridization and range expansion in tamarisk beetles (Diorhabda spp.) introduced to North America for classical biological control
Stahlke, A. R.; Bitume, E. V.; Ozsoy, A. Z.; Bean, D. W.; Veillet, A.; Clark, M. I.; Clark, E. I.; Moran, P.; Hufbauer, R. A.; Hohenlohe, P. A.
10.1101/2021.05.18.444725 — evolutionary biology — Posted on 2021-05-18
1829 Hypertrophic Chondrocytes Serve as a Reservoir for Unique Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development
Long, J. T.; Leinroth, A.; Liao, Y.; Ren, Y.; Mirando, A. J.; Nguyen, T.; Guo, W.; Sharma, D.; Wu, C.; Cheah, K.; Karner, C. M.; Hilton, M. J.
10.1101/2021.05.18.444731 — developmental biology — Posted on 2021-05-18
1830 Mechanosensitive calcium signaling promotes epithelial tight junction remodeling by activating RhoA
Varadarajan, S.; Stephenson, R. E.; Misterovich, E. R.; Wu, J. L.; Erofeev, I. S.; Goryachev, A. B.; Miller, A. L.
10.1101/2021.05.18.444663 — cell biology — Posted on 2021-05-18
1831 Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived
Kukida, M.; Cai, L.; Ye, D.; Sawada, H.; Katsumata, Y.; Franklin, M. K.; Hecker, P. I.; Campbell, K. S.; Danser, A. H. J.; Mullick, A. E.; Daugherty, A.; Temel, R. E.; Lu, H. S.
10.1101/2021.05.18.444555 — molecular biology — Posted on 2021-05-18
1834 Phenotypic and Kinetic Changes of Myeloid Lineage Cells in Innate Response to Chikungunya Infection in Cynomolgus Macaques
Beddingfield, B. J.; Sugimoto, C.; Kuroda, M. J.; Wang, E.; Weaver, S. C.; Russell-Lodrigue, K. E.; Killeen, S. Z.; ROY, C. J.
10.1101/2021.05.18.444706 — immunology — Posted on 2021-05-18
1835 Functional and structural modifications of influenza antibodies during pregnancy
Jennewein, M. F.; Kosikova, M.; Noelette, F. J.; Radvak, P.; Boudreau, C. M.; Campbell, J. D.; Chen, W. H.; Xie, H.; Alter, G.; Pasetti, M. F.
10.1101/2021.05.18.444722 — immunology — Posted on 2021-05-18
1836 Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly
Trotter, J. H.; Dargaei, Z.; Sclip, A.; Essayan-Perez, S.; Liakath-Ali, K.; Raju, K.; Nabet, A.; Liu, X.; Sudhof, T.
10.1101/2020.08.21.262097 — neuroscience — Posted on 2021-05-18
1837 Compensatory functional connectome changes in a rat model of traumatic brain injury
Yang, Z.; Zhu, T.; Pompilus, M.; Fu, Y.; Zhu, J.; Arjona, K.; Arja, R. D.; Grudny, M. M.; Plant, H. D.; Bose, P.; Wang, K. K.; Febo, M.
10.1101/2021.05.17.444382 — neuroscience — Posted on 2021-05-18
1841 Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons
Woldegebriel, R.; Kvist, J.; White, M.; Sinkko, M.; Hanninen, S.; Sainio, M. T.; Torregrosa Munumer, R.; Harjuhaahto, S.; Huber, N.; Herukka, S.-K.; Haapasalo, A.; Carpen, O.; Bassett, A.; Ylikallio, E.; Sreedharan, J.; Tyynismaa, H.
10.1101/2021.05.18.444636 — neuroscience — Posted on 2021-05-18
1842 A transcriptomics-guided drug target discovery strategy identifies novel receptor ligands for lung regeneration
Wu, X.; Bos, S.; Conlon, T. M.; Ansari, M.; Verschut, V.; Verkleij, L. A.; DAmbrosi, A.; Matveyenko, A.; Schiller, H. B.; Königshoff, M.; Schimdt, M.; Kistemaker, L. E. M.; Yildirim, Önder A.; Gosens, R.
10.1101/2021.05.18.444655 — pharmacology and toxicology — Posted on 2021-05-18
1844 The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation
Sepich-Poore, C.; Zheng, Z.; Schmitt, E.; Wen, K.; Zhang, Z. S.; Cui, X.-L.; Dai, Q.; Zhu, A. C.; Zhang, L.; Sanchez Castillo, A.; Zhuang, X.; He, C.; Nachtergaele, S.
10.1101/2021.05.18.444567 — biochemistry — Posted on 2021-05-18
1846 C. elegans DSB-3 Reveals Conservation and Divergence among Protein Complexes Promoting Meiotic Double-Strand Breaks
Hinman, A. W.; Yeh, H.-Y.; Roelens, B.; Yamaya, K.; Woglar, A.; Bourbon, H.-M.; Chi, P.; Villeneuve, A. M.
10.1101/2021.05.14.444243 — genetics — Posted on 2021-05-18
1847 Adaptive foraging behaviour increases vulnerability to climate change
Gauzens, B.; Rosenbaum, B.; Kalinkat, G.; Boy, T.; Jochum, M.; Kortsch, S.; O'Gorman, E. J.; Brose, U.
10.1101/2021.05.05.442768 — ecology — Posted on 2021-05-18
1848 SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
Tapia del Fierro, A.; den Hamer, B.; Jansz, N.; Chen, K.; Beck, T.; Vanyai, H.; Benetti, N.; Gurzau, A. D.; Daxinger, L.; Xue, S.; Nguyen Ly, T. T.; Wanigasuriya, I.; Breslin, K.; Oey, H.; Krom, Y.; van der Hoorn, D.; Bouwman, L. F.; Ritchie, M. E.; Reversade, B.; Prin, F.; Mohun, T.; van der Maarel, S. M.; McGlinn, E.; Murphy, J. M.; Keniry, A.; de Greef, J. C.; Blewitt, M. E.
10.1101/2021.05.12.443934 — molecular biology — Posted on 2021-05-18
1850 FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells
Zeng, N.; Theresine, M.; Capelle, C.; Patil, N.; Masquelier, C.; Davril, C.; Baron, A.; Coowar, D.; Dervillez, X.; Poli, A.; Leonard, C.; Balling, R.; Ollert, M.; Zimmer, J.; Hefeng, F. Q.
10.1101/2020.08.26.268490 — immunology — Posted on 2021-05-18
1852 Infants' cortex undergoes microstructural growth coupled with myelination
Natu, V. S.; Rosenke, M.; Wu, H.; Querdasi, F. R.; Kular, H.; Lopez-Alvarez, N.; Grotheer, M.; Berman, S.; Mezer, A.; Grill-Spector, K.
10.1101/2021.03.16.435703 — neuroscience — Posted on 2021-05-18
1853 Thermodynamics drives coenzyme redundancy in metabolism
Goldford, J. E.; George, A. B.; Flamholz, A. E.; Segre, D.
10.1101/2021.05.17.444566 — systems biology — Posted on 2021-05-18
1856 New cellular models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor
Bhalla, A. D.; Landers, S. M.; Singh, A. K.; Yeagley, M. G.; Meyerson, G. S. B.; Mulder, Z. A.; Delgado-Baez, C. B.; Dunnand, S.; Kochat, V.; Tomczak, K. J.; Nguyen, T.; Ma, X.; Bolshakov, S.; Menegaz, B. A.; Lamhamedi-Cherradi, S.-E.; Ludwig, J. A.; Beird, H. C.; Mao, X.; Song, X.; Ingram, D. R.; Wang, W.-L.; Lazar, A. J.; McCutcheon, I. E.; Slopis, J. M.; Rai, K.; Zhang, J.; Lev, D. C.; Torres, K. E.
10.1101/2021.05.13.443902 — cancer biology — Posted on 2021-05-18
1857 Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate
Holmes, J. B.; Liu, V.; Caulkins, B. G.; Hilario, E.; Ghosh, R. K.; Drago, V. N.; Young, R. P.; Romero, J.; Gill, A. D.; Bogie, P. M.; Paulino, J.; Wang, X.; Riviere, G.; Bosken, Y. K.; Struppe, J.; Hassan, A.; Guidoulianov, J.; Perrone, B.; Chang, C.-e. A.; Vigier, F. M.-; Long, J. R.; Hooley, R. J.; Mueser, T. C.; Dunn, M. F.; Mueller, L. J.
10.1101/2021.05.12.443852 — biophysics — Posted on 2021-05-18
1858 Rules for designing protein fold switches and their implications for the folding code
Chen, Y.; He, Y.; Ruan, B.; Choi, E. J.; Chen, Y.; Motabar, D.; Solomon, T.; Simmerman, R.; Kauffman, T.; Gallagher, D. T.; Orban, J.; BRYAN, P. N.
10.1101/2021.05.18.444643 — biophysics — Posted on 2021-05-18
1859 Probing universal protein dynamics using residue-level Gibbs free energy
Smit, J. H.; Krishnamurthy, S.; Srinivasu, B. Y.; Parakra, R.; Karamanou, S.; Economou, A.
10.1101/2020.09.30.320887 — bioinformatics — Posted on 2021-05-18
1865 Elucidating the diversity of microeukaryotes and epi-endophytes in the brown algal holobiome
Bjorbaekmo, M. F. M.; Brodie, J.; Krabberod, A. K.; Logares, R.; Attwood, S.; Fredriksen, S.; Fuss, J.; Wold-Dobbe, A.; Shalchian-Tabrizi, K.; Bass, D.
10.1101/2021.05.09.443287 — ecology — Posted on 2021-05-18
1866 Predicting missing links in global host-parasite networks
Farrell, M. J.; Elmasri, M.; Stephens, D. A.; Davies, T. J.
10.1101/2020.02.25.965046 — ecology — Posted on 2021-05-18
1867 An Atlas of Cortical Arealization Identifies Dynamic Molecular Signatures
Bhaduri, A.; Sandoval-Espinosa, C.; Otero-Garcia, M.; Oh, I.; Yin, R.; Eze, U. C.; Nowakowski, T. J.; Kriegstein, A. R.
10.1101/2021.05.17.444528 — developmental biology — Posted on 2021-05-18
1869 Dynamic interactions and intracellular fate of label-free GO within mammalian cells: role of lateral sheet size
Chen, Y.; Rivers-Auty, J.; Crica, L. E.; Rosano, V.; Arranz, A. E.; Loret, T.; Spiller, D.; Bussy, C.; Kostarelos, K.; Vranic, S.
10.1101/805200 — cell biology — Posted on 2021-05-18
1870 A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge
Gehrmann, T.; Beekman, M.; Deelen, J.; Partridge, L.; van de Rest, O.; Mei, H.; Raz, Y.; de Groot, L.; van der Breggen, R.; Reinders, M. J. T.; van den Akker, E. B.; Slagboom, P. E.
10.1101/2021.05.18.444591 — molecular biology — Posted on 2021-05-18
1871 Surfactin stimulated by pectin molecular patterns and root exudates acts as a key driver of Bacillus-plant mutualistic interaction
Hoff, G.; Arguelles Arias, A.; Boubsi, F.; Prsic, J.; Meyer, T.; Ibrahim, H. M. M.; Steels, S.; Luzuriaga, P.; Legras, A.; Franzil, L.; Lequart, M.; Rayon, C.; Osorio, V.; de Pauw, E.; Lara, Y.; Deboever, E.; de Coninck, B.; Jacques, P.; Deleu, M.; Petit, E.; Van Wuytswinkel, O.; Ongena, M.
10.1101/2021.02.22.432335 — microbiology — Posted on 2021-05-18
1872 Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22
Schnepf, D.; Hernandez, P.; Mahlakoiv, T.; Crotta, S.; Sullender, M. E.; Peterson, S. T.; Ohnemus, A.; Michiels, C.; Gentle, I.; Dumoutier, L.; Reis, C. A.; Diefenbach, A.; Wack, A.; Baldridge, M. T.; Staeheli, P.
10.1101/2021.02.18.431818 — immunology — Posted on 2021-05-18
1877 Asymptomatic gut colonization by extended-spectrum beta-lactamase-producing Escherichia coli is not associated with an altered gut microbiome or metabolome in Dutch adults
Ducarmon, Q. R.; Zwittink, R. D.; Willems, R. P. J.; Verhoeven, A.; Nooij, S.; van der Klis, F. R. M.; Franz, E.; Kool, J.; Giera, M.; Vandenbroucke-Grauls, C. M. J. E.; Fuentes, S.; Kuijper, E. J.
10.1101/2021.05.18.444613 — microbiology — Posted on 2021-05-18
1879 Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat.
Chandran, V.; Bermudez, M.-L.; Koka, M.; Pawale, D.; Vishnubhotla, R.; Alankar, S.; Maturi, R.; Subramaniam, B.; Sadhasivam, S.
10.1101/2021.05.18.444668 — genomics — Posted on 2021-05-18
1880 Somatic structural variant formation is guided by and influences genome architecture
Sidiropoulos, N.; Mardin, B. R.; Rodriguez-Gonzalez, F. G.; Garg, S.; Stütz, A. M.; Korbel, J. O.; Aiden, E. L.; Weischenfeldt, J.
10.1101/2021.05.18.444682 — genomics — Posted on 2021-05-18
1881 Standard PBMC cryopreservation selectively decreases detection of nine clinically-relevant T-cell markers
Capelle, C. M.; Cire, S.; Ammerlaan, W.; Konstantinou, M.; Balling, R.; Betsou, F.; Cosma, A.; Ollert, M.; Hefeng, F. Q.
10.1101/2021.05.18.443634 — immunology — Posted on 2021-05-18
1882 Encoding of inflammatory hyperalgesia in mice spinal cord
Barkai, O.; Butterman, R.; Katz, B.; Lev, S.; Binshtok, A. M.
10.1101/2021.05.18.444665 — neuroscience — Posted on 2021-05-18
1885 Somatosensory signals from the controllers of an extra robotic finger support motor learning
Amoruso, E.; Dowdall, L.; Kollamkulam, M. T.; Ukaegbu, O.; Kieliba, P.; NG, T.; Dempsey-Jones, H.; Clode, D.; Makin, T. R.
10.1101/2021.05.18.444661 — neuroscience — Posted on 2021-05-18
1886 Mechanism of the Switch from NO to H2O2 in Endothelium-Dependent Vasodilation in Diabetes
Juguilon, C.; Wang, Z.; Wang, Y.; Jamaiyar, A.; Enrick, M.; Gadd, J.; Chen, C.-L. W.; Pu, A.; Kolz, C.; Ohanyan, V.; Chen, Y.-R.; Zhang, Y.; Chilian, W. W.; Yin, L.
10.1101/2021.05.18.444667 — physiology — Posted on 2021-05-18
1887 Implications Derived from S-Protein Variants of SARS-CoV-2 from Six Continents
Hassan, S. S.; Lundstrom, K.; Pal Choudhury, P.; Palu, G.; Uhal, B.; Kandimalla, R.; Seyran, M.; Lal, A.; Sherchan, S. P.; Azad, G. K.; Aljabali, A. A. A.; Brufsky, A.; Serrano-Aroca, A.; Adadi, P.; Abd El-Aziz, T. M.; Redwan, E. M.; Takayama, K.; Barh, D.; Rezaei, N.; Tambuwala, M.; Uversky, V. N.
10.1101/2021.05.18.444675 — bioinformatics — Posted on 2021-05-18
1888 Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples
Laajala, E.; Halla-aho, V.; Grönroos, T.; Ullah, U.; Vähä-Mäkilä, M.; Nurmio, M.; Kallionpää, H.; Lietzen, N.; Mykkänen, J.; Rasool, O.; Toppari, J.; Oresic, M.; Knip, M.; Lund, R. J.; Lahesmaa, R.; Lähdesmäki, H.
10.1101/2021.05.18.444359 — bioinformatics — Posted on 2021-05-18
1889 Incorporating structural knowledge into unsupervised deep learning for two-photon imaging data
Eichin, F.; Hackenberg, M.; Broichhagen, C.; Kilias, A.; Schmoranzer, J.; Bartos, M.; Binder, H.
10.1101/2021.05.18.443587 — bioinformatics — Posted on 2021-05-18
1891 Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells
Pavlaki, I.; Shapiro, M.; Pisignano, G.; Telenius, J.; Munoz Descalzo, S.; Williams, R. J.; Hughes, J. R.; Vance, K. W.
10.1101/2021.05.18.442939 — genomics — Posted on 2021-05-18
1892 Genomic evidence for inbreeding depression and purging of deleterious genetic variation in Indian tigers
Khan, A.; Patel, K.; Shukla, H.; Viswanathan, A.; van der Valk, T.; Borthakur, U.; Nigam, P.; Zachariah, A.; Jhala, Y.; Kardos, M.; Ramakrishnan, U.
10.1101/2021.05.18.444660 — evolutionary biology — Posted on 2021-05-18
1893 An intranasal ASO therapeutic targeting SARS-CoV-2
Zhu, C.; Lee, J. Y.; Woo, J. Z.; Xu, L.; Nguyenla, X.; Yamashiro, L. H.; Ji, F.; Biering, S. B.; Dis, E. V.; Gonzalez, F.; Fox, D.; Rustagi, A.; Pinsky, B. A.; Blish, C. A.; Chiu, C.; Harris, E.; Sadreyev, R. I.; Stanley, S.; Kauppinen, S.; Rouskin, S.; Näär, A. M.
10.1101/2021.05.17.444397 — microbiology — Posted on 2021-05-18
1895 SARS-like coronaviruses in horseshoe bats (Rhinolophus spp.) in Russia, 2020.
Alkhovsky, S. V.; Lenshin, S. V.; Romashin, A. V.; Vishnevskaya, T. V.; Vyshemirsky, O. I.; Bulycheva, Y. I.; Lvov, D. K.; Gitelman, A. K.
10.1101/2021.05.17.444362 — microbiology — Posted on 2021-05-18
1896 Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Salzer, R.; Clark, J. J.; Vaysburd, M.; Chang, V. T.; Albecka-Moreau, A.; Kiss, L.; Sharma, P.; Gonzalez Llamazares, A.; Kipar, A.; Hiscox, J. A.; Owen, A.; Aricescu, A. R.; Stewart, J. P.; James, L. C.; Lowe, J.
10.1101/2021.05.18.444622 — immunology — Posted on 2021-05-18
1902 PAK1 and PAK2 in the cell metabolism regulation
Koranova, T.; Dvoracek, L.; Grebenova, D.; Roselova, P.; Obr, A.; Kuzelova, K.
10.1101/2021.05.18.444625 — cell biology — Posted on 2021-05-18
1904 Whole-ExM: Expansion microscopy imaging of all anatomical structures of whole larval zebrafish
Sim, J.; Park, C. E.; Cho, I.; Min, K.; Lee, J.-S.; Chong, Y.; Kim, J.; Kang, J. S.; Piatkevich, K. D.; Jung, E. E.; Kwon, S.-K.; Yoon, Y.-G.; Boyden, E. S.; Chang, J.-B.
10.1101/2021.05.18.443629 — developmental biology — Posted on 2021-05-18
1905 A Drosophila Toolkit for Imaging of HA-tagged Proteins Unveiled a Block in Autophagy Flux in the Last Instar Larval Fat Body
Murakawa, T.; Nakamura, T.; Kawaguchi, K.; Murayama, F.; Zhao, N.; Stasevich, T.; Kimura, H.; Fujita, N.
10.1101/2021.05.18.444637 — cell biology — Posted on 2021-05-18
1910 Customizing Multifunctional Neural Interfaces through Thermal Drawing Process
Antonini, M.-J.; Sahasrabudhe, A.; Tabet, A.; Schwalm, M.; Rosenfeld, D.; Garwood, I.; Park, J.; Loke, G.; Khudiyev, T.; Kanik, M.; Corbin, N.; Canales, A.; Jasanoff, A.; Fink, Y.; Anikeeva, P.
10.1101/2021.05.17.444577 — neuroscience — Posted on 2021-05-18
1913 A systems-guided approach to discover the intracellular target of a novel evolution-drug lead
Chowdhury, S.; Zielinski, D. C.; Dalldorf, C.; Rodrigues, J. V.; Palsson, B.; Shakhnovich, E.
10.1101/2021.05.17.444532 — systems biology — Posted on 2021-05-18
1914 Thermodynamics drives coenzyme redundancy in metabolism
Goldford, J. E.; George, A. B.; Flamholz, A. E.; Segre, D.
10.1101/2021.05.17.444566 — systems biology — Posted on 2021-05-18
1915 Glycine-Rich RNA-Binding Protein 7 interacts with and potentiates effector-induced immunity by Gpa2 and Rx1 based on an intact RNA Recognition Motif
Sukarta, O. C.; Zheng, Q.; Slootweg, E. J.; Mekken, M.; Mendel, M.; Putker, V.; Overmars, H.; Pomp, R.; Roosien, J.; Boeren, S.; Smant, G.; Goverse, A.
10.1101/2021.05.18.444452 — plant biology — Posted on 2021-05-18
1916 Genome-Wide High Resolution Expression Map and Functions of Key Cell Fate Determinants Reveal the Dynamics of Crown Root Development in Rice
Garg, T.; Singh, Z.; Chennakesavulu, K.; Dwivedi, A. K.; Varapparambathu, V.; Singh, R. S.; Mushahary, K. K. K.; Yadav, M.; Sircar, D.; Chandran, D.; Prasad, K.; Jain, M.; Yadav, S. R.
10.1101/2020.06.11.131565 — plant biology — Posted on 2021-05-18
1918 Rules for designing protein fold switches and their implications for the folding code
Chen, Y.; He, Y.; Ruan, B.; Choi, E. J.; Chen, Y.; Motabar, D.; Soloman, T.; Simmerman, R.; Kauffman, T.; Gallagher, D. T.; Orban, J.; BRYAN, P. N.
10.1101/2021.05.18.444643 — biophysics — Posted on 2021-05-18
1923 Systematic characterization of short intronic splicing-regulatory elements
Gao, Y.; Lin, K.-T.; Yang, Y.; Bai, J.; Wang, L.; Sun, J.; Sheng, L.; Krainer, A.; Hua, Y.
10.1101/2021.05.17.444464 — molecular biology — Posted on 2021-05-18
1924 A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation
Enervald, E.; Powell, L. M.; Boteva, L.; Foti, R.; Ruiz, N. B.; Kibar, G.; Piszczek, A.; Cavaleri, F.; Vingron, M.; Cerase, A.; Buonomo, S.
10.1101/2020.06.04.133512 — molecular biology — Posted on 2021-05-18
1926 Fiberoptic Probe For Hemodynamic Spectroscopy in Freely Moving Mice Shows Cerebrovascular Dysregulation In Alzheimers and Glioma Models
Gareau, D. S.; Snuderl, M.; Thomas, C.; Bayin, N. S.; Placantonakis, D.; Zou, J.; Yaroslavsky, A.; Dietz, M. P.; Jacques, S. L.; Strickland, S.; Krueger, J. G.; Ahn, H. J.
10.1101/2021.05.17.444224 — neuroscience — Posted on 2021-05-18
1927 Mobile Footprinting: Linking Individual Distinctiveness in Mobility Patterns to Mood, Sleep, and Brain Functional Connectivity
Xia, C. H.; Barnett, I.; Tapera, T.; Cui, Z.; Moore, T.; Adebimpe, A.; Rush, S.; Piiwaa, K.; Murtha, K.; Linguiti, S.; Leibenluft, E.; Martin, M.; Martin, M. L.; Calkins, M. E.; Roalf, D.; Wolf, D.; Bassett, D. S.; Lydon-Staley, D. M.; Baker, J.; Ungar, L.; Satterthwaite, T. D.
10.1101/2021.05.17.444568 — neuroscience — Posted on 2021-05-18
1929 Cortical network structure mediates response to stimulation: an optogenetic study in non-human primates
Bloch, J.; Greaves-Tunnell, A.; Shea-Brown, E.; Harchaoui, Z.; Shojaie, A.; Yazdan-Shahmorad, A.
10.1101/2021.05.17.444526 — neuroscience — Posted on 2021-05-18
1930 The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment
Callegaro, G.; Kunnen, S. J.; Trairatphisan, P.; Grosdidier, S.; Niemeijer, M.; den Hollander, W.; Guney, E.; Gonzalez, J. P.; Furlong, L.; Webster, Y. W.; Saez-Rodriguez, J.; Sutherland, J. J.; Mollon, J.; Stevens, J. L.; van de Water, B.
10.1101/2021.05.17.444463 — pharmacology and toxicology — Posted on 2021-05-18
1931 Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokers
Trefzer, T. B.; Schneider, M. A.; Jechow, K.; Chua, L. R.; Muley, T.; Winter, H.; Kriegsmann, M.; Meister, M.; Eils, R.; Conrad, C.
10.1101/2021.05.18.444603 — cancer biology — Posted on 2021-05-18
1933 A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo
Lagunas, T.; Plassmyer, S. P.; Friedman, R. Z.; Rieger, M. A.; Fischer, A. D.; Lucero, A. F. A.; An, J.-Y.; Sanders, S. J.; Cohen, B. A.; Dougherty, J. D.
10.1101/2021.05.17.444514 — genetics — Posted on 2021-05-18
1938 Polarized Dishevelled dissolution and condensation drives embryonic axis specification in oocytes
Swartz, Z.; Tan, T. H.; Perillo, M.; Fakhri, N.; Wessel, G. M.; Wikramanayake, A.; Cheeseman, I. M.
10.1101/2021.05.17.444558 — cell biology — Posted on 2021-05-18
1939 A systematic comparison of fibroblasts derived from postmortem human dura mater versus dermal epithelium for neurodegenerative disease modeling
Argouarch, A. R.; Cosme, C. G.; Garcia, K.; Corrales, C. I.; Nana, A. L.; Karydas, A. M.; Spina, S.; Grinberg, L. T.; Miller, B.; Goodarzi, H.; Seeley, W. W.; Kao, A. W.
10.1101/2021.05.17.444554 — cell biology — Posted on 2021-05-18
1940 Maf/ham1-like pyrophosphatases, host-specific partners of viral RNA-dependent RNA polymerases
Valli, A. A.; Garcia Lopez, R.; Ribaya, M.; Martinez, F. J.; Garcia Gomez, D.; Garcia, B.; Gonzalo, I.; Gonzalez, A.; Pasin, F.; Montanuy, I.; Rodriguez-Gonzalo, E.; Garcia, J. A.
10.1101/2021.05.18.444600 — molecular biology — Posted on 2021-05-18
1941 Biochemical Barriers on the Path to Ocean Anoxia?
Giovannoni, S. J.; Chan, F.; Davis, E. W.; Deutsch, C.; Wolf, S. S.
10.1101/2021.05.17.444596 — microbiology — Posted on 2021-05-18
1942 Prophylactic inhibition of colonization by Streptococcus pneumoniae with the secondary bile acid metabolite deoxycholic acid
Vidal, J. E.; Wier, M. N.; Angulo-Zamudio, U.; McDevitt, E.; Vidal, A. G.; Alibayov, B.; Scasny, A.; Wong, S. M.; Akerley, B. J.; McDaniel, L. S.
10.1101/2021.05.17.444594 — microbiology — Posted on 2021-05-18
1944 Tafazzin regulates the function of lipopolysaccharide activated B lymphocytes in mice
Zegallai, H. M.; Abu-El-Rub, E.; Cole, L. K.; Field, J.; Mejia, E. M.; Gordon, J. W.; Hatch, A. J.; Hatch, G. M.
10.1101/2021.05.17.444507 — immunology — Posted on 2021-05-18
1945 Synaptic Plasticity in the Agranular Insular Cortex Predicts Escalated Ethanol Consumption
Shillinglaw, J. E.; Aziz, H. C.; Carrizales, D. G.; Morrisett, R. A.; Mangieri, R. A.
10.1101/2021.05.17.444509 — neuroscience — Posted on 2021-05-18
1946 Rat sensitivity to multipoint statistics is predicted by efficient coding of natural scenes
Caramellino, R.; Piasini, E.; Buccellato, A.; Carboncino, A.; Balasubramanian, V.; Zoccolan, D.
10.1101/2021.05.17.444510 — neuroscience — Posted on 2021-05-18
1947 Cortical Oscillatory Dysrhythmias in Visual Snow Syndrome: A MEG Study
Hepschke, J. L.; Seymour, R. A.; He, W. A.; Etchell, A.; Sowman, P. F.; Fraser, C.
10.1101/2021.05.17.444460 — neuroscience — Posted on 2021-05-18
1950 Attentional modulation of intrinsic timescales in visual cortex and spatial networks
Zeraati, R.; Shi, Y.-L.; Steinmetz, N. A.; Gieselmann, M. A.; Thiele, A.; Moore, T.; Levina, A.; Engel, T. A.
10.1101/2021.05.17.444537 — neuroscience — Posted on 2021-05-18
1951 Deconstructing the Cortical Sources of Frequency Following Responses to Speech: A Cross-species Approach
Gnanteja, G. N.; Rupp, K.; Llanos, F.; Remick, M.; Pernia, M.; Sadagopan, S.; Teichert, T.; Abel, T.; Chandresekaran, B.
10.1101/2021.05.17.444462 — neuroscience — Posted on 2021-05-18
1952 Astrocyte Ca2+ Signaling is Facilitated in an Scn1a+/- Mouse Model of Dravet Syndrome
Uchino, K.; Ikezawa, W.; Tanaka, Y.; Deshimaru, M.; Kubota, K.; Watanabe, T.; Katsurabayashi, S.; Iwasaki, K.; Hirose, S.
10.1101/2021.05.18.444602 — neuroscience — Posted on 2021-05-18
1954 DiversityScanner: Robotic discovery of small invertebrates with machine learning methods
Wuehrl, L.; Pylatiuk, C.; Giersch, M.; Lapp, F.; von Rintelen, T.; Balke, M.; Schmidt, S.; Cerretti, P.; Meier, R.
10.1101/2021.05.17.444523 — zoology — Posted on 2021-05-18
1960 Toughening mechanisms for the attachment of architectured materials: The mechanics of the tendon enthesis
Golman, M.; Abraham, A. C.; Kurtaliaj, I.; Marshall, B. P.; Hu, Y. J.; Schwartz, A. G.; Guo, X. E.; Birman, V.; Thurner, P. J.; Genin, G. M.; Thomopoulos, S.
10.1101/2021.05.17.444505 — bioengineering — Posted on 2021-05-18
1962 Development of a Low-Cost System for Simultaneous Longitudinal Biological Imaging
Ly, V. T.; Baudin, P. V.; Pansodtee, P.; Jung, E. A.; Voitiuk, K.; Rosen, Y.; Willsey, H. R.; Mantalas, G. L.; Seiler, S. T.; Selberg, J. A.; Cordero, S. A.; Ross, J. M.; Pollen, A. A.; Nowakowski, T. J.; Haussler, D.; Mostajo-Radji, M. A.; Salama, S.; Teodorescu, M.
10.1101/2021.05.17.443454 — bioengineering — Posted on 2021-05-18
1963 Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations
Kafkova, A.; Tilokani, L.; Trcka, F.; Sramkova, V.; Vancova, M.; Bily, T.; Nebesarova, J.; Prudent, J.; Trnka, J.
10.1101/2021.03.09.434520 — biochemistry — Posted on 2021-05-18
1964 Structure Activity Relationship of USP5 Allosteric Inhibitors
Mann, M. K.; Zepeda-Velazquez, C. A.; Alvarez, H. G.; Dong, A.; Kiyota, T.; Aman, A.; Arrowsmith, C.; Al-Awar, R.; Harding, R. J.; Schapira, M.
10.1101/2021.05.17.444542 — biochemistry — Posted on 2021-05-18
1965 NEOage clocks - Epigenetic clocks to estimate post-menstrual and postnatal age in preterm infants
Graw, S.; Camerota, M.; Carter, B. S.; Helderman, J.; Hofheimer, J. A.; McGowan, E. C.; Neal, C. R.; Pastyrnak, S. L.; Smith, L. M.; DellaGrotta, S. A.; Dansereau, L. M.; Padbury, J. F.; O'Shea, T. M.; Lester, B. M.; Marsit, C. J.; Everson, T. M.
10.1101/2021.05.13.444018 — genomics — Posted on 2021-05-18
1967 Comparative and systems analyses of Leishmania spp. non-coding RNAs through developmental stages
Martinez-Hernandez, J. E.; Aliaga-Tobar, V.; Gonzalez, C.; Monte-Neto, R.; Martin, A. J. M.; Maracaja-Coutinho, V.
10.1101/2021.05.17.444077 — genomics — Posted on 2021-05-18
1971 Bayesian inference of population prevalence
Ince, R. A. A.; Paton, A. T.; Kay, J. W.; Schyns, P. G.
10.1101/2020.07.08.191106 — neuroscience — Posted on 2021-05-18
1973 Barley RIC157 is involved in RACB-mediated susceptibility to powdery mildew
Engelhardt, S.; Trutzenberg, A.; Probst, K.; Hofer, J.; McCollum, C.; Kopischke, M.; Huckelhoven, R.
10.1101/848226 — plant biology — Posted on 2021-05-18
1974 KmerKeys: a web resource for searching indexed genome assemblies and variants
Pavlichin, D. S.; Lee, H.; Greer, S. U.; Grimes, S. M.; Weissman, T.; Ji, H. P.
10.1101/2021.05.17.444256 — bioinformatics — Posted on 2021-05-18
1976 Learning interpretable cellular responses tocomplex perturbations in high-throughput screens
Lotfollahi, M.; Klimovskaia, A.; De Donno, C.; Ji, Y.; Ibarra, I. L.; Wolf, F. A.; Yakubova, N.; Theis, F. J.; Lopez-Paz, D.
10.1101/2021.04.14.439903 — bioinformatics — Posted on 2021-05-18
1979 Epigenetic predictors of maximum lifespan and other life history traits in mammals
Li, C. Z.; Haghani, A.; Robeck, T. R.; Villar, D.; Lu, A. T.; Zhang, J.; Faulkes, C. G.; Vu, H.; Ablaeva, J.; Adams, D. M.; Ardehali, R.; Arneson, A.; Baker, C. S.; Belov, K.; Blumstein, D. T.; Bors, E. K.; Breeze, C. E.; Brooke, R. T.; Brown, J. L.; Caulton, A.; Cavin, J. M.; Chatzistamou, I.; Chen, H.; Chiavellini, P.; Choi, O.-W.; Clarke, S.; DeYoung, J.; Emmons, C. K.; Emmrich, S.; Fei, Z.; Ferguson, S. H.; Finno, C. J.; Flower, J. E.; Gaillard, J.-M.; Garde, E.; Gladyshev, V. N.; Goya, R. G.; Hanson, M. B.; Haulena, M.; Herrick, K.; Hogan, A. N.; Hogg, C. J.; Hore, T. A.; Jasinska, A. J.;
10.1101/2021.05.16.444078 — evolutionary biology — Posted on 2021-05-18
1981 SARS-CoV-2 infects lung epithelial cells and induces senescence and an inflammatory response in patients with severe COVID-19
Evangelou, K.; Veroutis, D.; Foukas, P. G.; Paschalaki, K.; Lagopati, N.; Dimitriou, M.; Papaspyropoulos, A.; Hazapis, O.; Polyzou, A.; Havaki, S.; Kotsinas, A.; Kittas, C.; Tzioufas, A. G.; de Leval, L.; Vassilakos, D.; Tsiodras, S.; Karakasiliotis, I.; Barnes, P. J.; Gorgoulis, V.
10.1101/2021.01.02.424917 — cell biology — Posted on 2021-05-18
1982 SARS-CoV-2 20I/501Y.V1 variant in the hamster model
Cochin, M.; Luciani, L.; Touret, F.; Driouich, J. S.; Petit, P.-R.; Moureau, G.; Baronti, C.; Thirion, L.; Maes, P.; Boudewijns, R.; Neyts, J.; de Lamballerie, X.; Nougairede, A.
10.1101/2021.04.19.440435 — microbiology — Posted on 2021-05-18
1983 SARS-CoV-2 B.1.617 emergence and sensitivity to vaccine-elicited antibodies
Ferreira, I.; Datir, R.; Papa, G.; Kemp, S.; Meng, B.; Rakshit, P.; Singh, S.; Pandey, R.; Ponnusamy, K.; Radhakrishnan, V. S.; INSACOG CONSORTIUM, ; Sato, K.; James, L.; Agrawal, A.; Gupta, R. K.
10.1101/2021.05.08.443253 — microbiology — Posted on 2021-05-18
1984 Viability of MS2 and Phi6 Bacteriophages on Carpet and Dust
Nastasi, N.; Renninger, N.; Bope, A.; Cochran, S. J.; Greaves, J.; Haines, S. R.; Balasubrahmaniam, N.; Stuart, K.; Panescu, J.; Bibby, K.; Hull, N. M.; Dannemiller, K. C.
10.1101/2021.05.17.444479 — microbiology — Posted on 2021-05-18
1985 Interplay between meropenem and human serum albumin on expression of carbapenem resistance genes and natural competence in Acinetobacter baumannii
Pimentel, C.; Le, C.; Tuttobene, M. R.; Subils, T.; Nishimura, B.; Traglia, G. M.; Perez, F.; Papp-Wallace, K. M.; Bonomo, R. A.; Tolmasky, M.; Ramirez, M. S.
10.1101/2021.05.14.444273 — microbiology — Posted on 2021-05-18
1986 Action imitation via trajectory-based or posture-based planning
Barhorst-Cates, E. M.; Isaacs, M. W.; Buxbaum, L. J.; Wong, A. L.
10.1101/2020.09.23.308635 — neuroscience — Posted on 2021-05-18
1987 Structure and dynamics of FCHo2 docking on membranes
El Alaoui, F.; Casuso, I.; Sanchez-Fuentes, D.; Arpin-Andre, C.; Rathar, R.; Baecker, V.; Castro, A.; Lorca, T.; Viaud, J.; Vassilopoulos, S.; Carretero-Genevrier, A.; Picas, L.
10.1101/2021.04.20.440640 — biophysics — Posted on 2021-05-18
1996 Landscape management for grassland multifunctionality
Neyret, M.; Fischer, M.; Allan, E.; Hoelzel, N.; Klaus, V.; Kleinebecker, T.; Krauss, J.; Le Provost, G.; Peter, S.; Schenk, N.; Simons, N. K.; van der Plas, F.; Binkenstein, J.; Boershig, C.; Jung, K.; Prati, D.; Schaefer, D.; Schaefer, M.; Schoening, I.; Schrumpf, M.; Tschapka, M.; Westphal, C.; Manning, P.
10.1101/2020.07.17.208199 — ecology — Posted on 2021-05-18
1997 Bimodal Endocytic Probe for Three-Dimensional Correlative Light and Electron Microscopy
Fermie, J.; de Jager, L.; Foster, H.; Veenendaal, T.; de Heus, C.; van Dijk, S.; ten Brink, C.; Oorschot, V.; Yang, L.; Li, W.; Muller, W.; Howes, S.; Carter, A.; Foerster, F.; Posthuma, G.; Gerritsen, H.; Klumperman, J.; Liv, N.
10.1101/2021.05.18.444466 — cell biology — Posted on 2021-05-18
1998 A quantitative map of nuclear pore assembly reveals two distinct mechanisms
Otsuka, S.; Tempkin, J. O. B.; Politi, A. Z.; Rybina, A.; Hossain, M. J.; Kueblbeck, M.; Callegari, A.; Koch, B.; Sali, A.; Ellenberg, J.
10.1101/2021.05.17.444137 — cell biology — Posted on 2021-05-18
2000 Stroke-related alterations ininter-areal communication
Allegra, M.; Favaretto, C.; Metcalf, N.; Corbetta, M.; Brovelli, A.
10.1101/2021.01.04.425190 — neuroscience — Posted on 2021-05-18
2004 Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit
Ashley, B.; Simner, C.; Manousopoulou, A.; Jenkinson, C.; Hey, F.; Frost, J. M.; Rezwan, F. I.; White, C. H.; Lofthouse, E. M.; Hyde, E.; Cooke, L.; Barton, S.; Mahon, P.; Curtis, E. M.; Moon, R. J.; Crozier, S. R.; Inskip, H. M.; Godfrey, K. M.; Holloway, J. W.; Cooper, C.; Jones, K. S.; Lewis, R. M.; Hewison, M.; Garbis, S. D.; Branco, M. R.; Harvey, N. C.; Cleal, J. K.
10.1101/2021.03.01.431439 — physiology — Posted on 2021-05-17
2006 LSD flattens the brain's energy landscape: evidence from receptor-informed network control theory
Singleton, S. P.; Luppi, A. I.; Carhart-Harris, R. L.; Cruzat, J.; Roseman, L.; Deco, G.; Kringelbach, M. L.; Stamatakis, E. A.; Kuceyeski, A.
10.1101/2021.05.14.444193 — neuroscience — Posted on 2021-05-17
2008 The Immune landscape of solid pediatric tumors.
Sherif, S.; Roelands, J.; Mifsud, W.; Ahmed, E.; Mifsud, B.; Bedognetti, D.; Hendrickx, W.
10.1101/2021.05.04.442503 — cancer biology — Posted on 2021-05-17
2011 Public attitudes towards free-roaming dogs and dog ownership practices in Bulgaria, Italy, and Ukraine
Smith, L. M.; Quinnell, R.; Munteanu, A.; Hartmann, S.; Dalla Villa, P.; Collins, L.
10.1101/2021.05.17.444435 — ecology — Posted on 2021-05-17
2013 An Atlas of Cortical Arealization Identifies Dynamic Molecular Signatures
Bhaduri, A.; Sandoval-Espinosa, C.; Otero-Garcia, M.; Oh, I.; Yin, R.; Eze, U. C.; Nowakowski, T. J.; Kriegstein, A. R.
10.1101/2021.05.17.444528 — developmental biology — Posted on 2021-05-17
2018 nGauge: Integrated and extensible neuron morphology analysis in Python
Walker, L. A.; Williams, J. S.; Li, Y.; Roossien, D. H.; Michki, N. S.; Cai, D.
10.1101/2021.05.13.443832 — neuroscience — Posted on 2021-05-17
2020 Ranking Reprogramming Factors for Directed Differentiation
Hammelman, J.; Patel, T.; Closser, M.; Wichterle, H.; Gifford, D. K.
10.1101/2021.05.14.444080 — systems biology — Posted on 2021-05-17
2023 Skeletal Muscle Transcriptome Alterations Related to Physical Function Decline in Older Mice
Graber, T. G.; Maroto, R.; Thompson, J.; Widen, S.; Man, Z.; Pajski, M. L.; Rasmussen, B. B.
10.1101/2021.05.17.444371 — physiology — Posted on 2021-05-17
2025 An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET
Zagotta, W. N.; Sim, B. S.; Nhim, A. K.; Raza, M. M.; Evans, E. G.; Venkatesh, Y.; Jones, C. M.; Mehl, R. A.; Petersson, J.; Gordon, S. E.
10.1101/2021.05.10.443484 — biophysics — Posted on 2021-05-17
2029 Gene duplications and phylogenomic conflict underlie major pulses of phenotypic evolution in gymnosperms
Stull, G. W.; Qu, X.-J.; Parins-Fukuchi, C.; Yang, Y.-Y.; Yang, J.-B.; Yang, Z.-Y.; Hu, Y.; Ma, H.; Soltis, P. S.; Soltis, D. E.; Li, D.-Z.; Smith, S. A.; Yi, T.-S.
10.1101/2021.03.13.435279 — evolutionary biology — Posted on 2021-05-17
2030 S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy
Brody, M. J.; Baldwin, T. A.; Subramani, A.; Kanisicak, O.; Vagnozzi, R. J.; Molkentin, J. D.
10.1101/2021.05.14.444015 — molecular biology — Posted on 2021-05-17
2032 Sequence and functional characterization of a public HIV-specific antibody clonotype
Murji, A. A.; Raju, N.; Qin, J. S.; Kaldine, H.; Janowska, K.; Fechter, E. F.; Mapengo, R.; Scheepers, C.; Setliff, I.; Acharya, P.; Morris, L.; Georgiev, I. S.
10.1101/2021.05.14.444191 — immunology — Posted on 2021-05-17
2033 Electrode pooling: How to boost the yield of switchable silicon probes for neuronal recordings
Lee, K. H.; Ni, Y.-L.; Colonell, J.; Karsh, B.; Putzeys, J.; Pachitariu, M.; Harris, T. D.; Meister, M.
10.1101/851691 — neuroscience — Posted on 2021-05-17
2037 Dynamical consequences of regional heterogeneity in the brains transcriptional landscape
Deco, G.; Kringelbach, M. L.; Arnatkeviciute, A.; Oldham, S.; Sabaroedin, K.; Rogasch, N. C.; Aquino, K. M.; Fornito, A.
10.1101/2020.10.28.359943 — neuroscience — Posted on 2021-05-17
2038 A genome-scale metabolic reconstruction provides insight into the metabolism of the thermophilic bacterium Rhodothermus marinus
Kristjansdottir, T.; Hreggvidsson, G. O.; Stefansson, S. K.; Gudmundsdottir, E. E.; Bjornsdottir, S. H.; Fridjonsson, O. H.; Karlsson, E. N.; Vanhalst, J.; Reynisson, B.; Gudmundsson, S.
10.1101/2021.05.17.444423 — systems biology — Posted on 2021-05-17
2040 T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma
Carey, R. M.; McMahon, D. B.; Rajasekaran, K.; Gopallawa, I.; Newman, J. G.; Basu, D.; White, E. A.; Lee, R. J.
10.1101/2021.05.17.444527 — cancer biology — Posted on 2021-05-17
2041 Condensin-driven loop extrusion on supercoiled DNA
Kim, E.; Gonzalez, A. M.; Pradhan, B.; van der Torre, J.; Dekker, C.
10.1101/2021.05.15.444164 — biophysics — Posted on 2021-05-17
2049 The genetic architecture of phenotypic diversity in the betta fish (Betta splendens)
Zhang, W.; Wang, H.; Brandt, D. Y. C.; Hu, B.; Sheng, J.; Wang, M.; Luo, H.; Guo, S.; Sheng, B.; Zeng, Q.; Peng, K.; Zhao, D.; Jian, S.; Wu, D.; Wang, J.; van Esch, J. H. M.; Shi, W.; Ren, J.; Nielsen, R.; Hong, Y.
10.1101/2021.05.10.443352 — genetics — Posted on 2021-05-17
2050 Evaluation of CRISPR gene-editing tools in zebrafish
Uribe-Salazar, J. M.; Sekar, A.; Kaya, G.; Weyenberg, K.; Ingamells, C.; Dennis, M. Y.
10.1101/2020.10.19.345256 — genetics — Posted on 2021-05-17
2054 A widely distributed genus of soil Acidobacteria genomically enriched in biosynthetic gene clusters
Crits-Christoph, A.; Diamond, S.; Al-Shayeb, B.; Valentin-Alvarado, L.; Banfield, J. F.
10.1101/2021.05.10.443473 — microbiology — Posted on 2021-05-17
2059 Nicotinic acetylcholine receptor partial antagonist polyamides from tunicates and their predatory sea slugs
Paguigan, N. D.; Tun, J. O.; Leavitt, L. S.; Lin, Z.; Chase, K.; Dowell, C.; Deering-Rice, C. E.; Lim, A. L.; Karthikeyan, M.; Hughen, R. W.; Zhang, J.; Peterson, R. T.; Reilly, C. A.; Light, A. R.; Raghuraman, S.; McIntosh, J. M.; Olivera, B. M.; Schmidt, E. W.
10.1101/2021.05.17.444536 — neuroscience — Posted on 2021-05-17
2060 Decentralized Brain Age Estimation using MRI Data
Basodi, S.; Raja, R.; Ray, B.; Gazula, H.; Liu, J.; Verner, E.; Calhoun, V. D.
10.1101/2021.05.10.443469 — neuroscience — Posted on 2021-05-17
2061 Evidence for microbiome-dependent chilling tolerance in Sorghum
Erlandson, S.; Bheemanahalli, R.; Narayana, N. K.; Johnson, M.; Graham, C.; Jagadish, K.; Subramanian, S.
10.1101/2021.03.02.433195 — plant biology — Posted on 2021-05-17
2062 Bexarotene derivatives modify responses in acute myeloid leukemia
Hadwiger, G.; di Martino, O.; Ferris, M. A.; Vu, A.; Frederick, T. E.; Bowman, G. R.; Ruminski, P.; Wagner, C.; Welch, J. S.
10.1101/2021.05.17.444475 — cancer biology — Posted on 2021-05-17
2064 Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics
Vahabikashi, A.; Sivagurunathan, S.; Nicdao, F. A. S.; Han, Y. L.; Park, C. Y.; Wong, X.; Tran, J. R.; Gundersen, G. G.; Reddy, K.; Luxton, G. G.; Guo, M.; Fredberg, J. J.; Zheng, Y.; Adam, S. A.; Goldman, R. D.
10.1101/2021.05.12.443683 — biophysics — Posted on 2021-05-17
2065 ALOHA: Aggregated local extrema splines for high-throughput dose-response analysis
Davidson, S. E.; Wheeler, M. W.; Auerbach, S. S.; Sivaganesan, S.; Medvedovic, M.
10.1101/2021.03.29.437588 — bioinformatics — Posted on 2021-05-17
2067 Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource
Kapun, M.; Nunez, J. C. B.; Bogaerts-Marquez, M.; Murga-Moreno, J.; Paris, M.; Outten, J.; Coronado-Zamora, M.; Tern, C.; Rota-Stabelli, O.; Garcia Guerreiro, M. P. P.; Casillas, S.; Orengo, D. J.; Puerma, E.; Kankare, M.; Ometto, L.; Loeschcke, V. V.; Onder, B. S.; Abbott, J. K.; Schaeffer, S. W.; Rajpurohit, S.; Behrman, E. L.; Schou, M. F.; Merritt, T. J. S.; Lazzaro, B. P. B.; Glaser-Schmitt, A.; Argyridou, E.; Staubach, F.; Wang, Y.; Tauber, E.; Serga, S. V.; Fabian, D. K.; Dyer, K. A.; Wheat, C. W.; Parsch, J.; Grath, S.; Savic Veselinovic, M.; Stamenkovic-Radak, M.; Jelic, M.; Buendia-R
10.1101/2021.02.01.428994 — genomics — Posted on 2021-05-17
2068 SMCHD1 variants may induce variegated expression in Facio Scapulo Humeral Dystophy and Bosma Arhinia and microphtalmia syndrome
Laberthonniere, C.; Chevalier, R.; Dion, C.; Delourme, M.; Hirst, D.; Adelaide, J.; Chaffanet, M.; Xue, S.; Nguyen, K.; Reversade, B.; Dejardin, J.; Baudot, A.; Robin, J. D.; Magdinier, F.
10.1101/2021.05.17.444338 — genetics — Posted on 2021-05-17
2071 Anaerobic oxidation of methane in sediments of a nitrate-rich, oligo-mesotrophic boreal lake
Rissanen, A. J.; Jilbert, T.; Simojoki, A.; Mangayil, R.; Aalto, S. L.; Peura, S.; Jantti, H.
10.1101/2021.02.12.426818 — ecology — Posted on 2021-05-17
2073 CoREST has a conserved role in facilitating SPR-5/LSD1 maternal reprogramming of histone methylation
Carpenter, B. S.; Scott, A. M.; Goldin, R. J.; Chavez, S. R.; Myrick, D. A.; Curlee, M. E.; Schmeichel, K. L.; Katz, D. J.
10.1101/2021.05.17.444472 — developmental biology — Posted on 2021-05-17
2075 Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters
Carrera, S.; O'Donnell, A.; Li, Y.; Nowicki-Osuch, K.; Baker, S. M.; Spiller, D.; Sharrocks, A. D.
10.1101/2021.05.17.444476 — molecular biology — Posted on 2021-05-17
2079 In mice and humans, the brain's blood vessels mature postnatally to acquire barrier and contractile properties
Slaoui, L.; Gilbert, A.; Federici, L.; Rancillac, A.; Gelot, A.; Favier, M.; Robil, N.; Letort, G.; Dias, K.; Jourdren, L.; Mailly, P.; Auvity, S.; Cisternino, S.; Cohen-Salmon, M.; Boulay, A.-C.
10.1101/2021.05.17.444486 — neuroscience — Posted on 2021-05-17
2080 Synaptic targets of functionally specialized R7 and R8 photoreceptors in the central eye and dorsal rim area of Drosophila
Kind, E.; Longden, K. D.; Nern, A.; Zhao, A.; Sancer, G.; Flynn, M.; Laughland, C.; Gezahegn, B.; Ludwig, H.; Thomson, A.; Obrusnik, T.; Alarcon, P. G.; Dionne, H.; Bock, D. D.; Rubin, G. M.; Reiser, M. B.; Wernet, M. F.
10.1101/2021.05.17.444480 — neuroscience — Posted on 2021-05-17
2081 "How do we do this at a distance?!" A descriptive study of remote undergraduate research programs during COVID-19
Erickson, O. A.; Cole, R. B.; Isaacs, J. M.; Alvarez-Clare, S.; Arnold, J.; Augustus-Wallace, A.; Ayoob, J. C.; Berkowitz, A.; Branchaw, J. L.; Burgio, K. R.; Cannon, C. H.; Ceballos, R. M.; Cohen, C. S.; Coller, H.; Disney, J.; Doze, V. A.; Eggers, M. J.; Farina, S.; Ferguson, E. L.; Gray, J. J.; Greenberg, J. T.; Hoffman, A.; Jensen-Ryan, D.; Kao, R. M.; Keene, A. C.; Kowalko, J. E.; Lopez, S. A.; Mathis, C.; Minkara, M.; Murren, C. J.; Ondrechen, M. J.; Ordonez, P.; Osano, A.; Padilla-Crespo, E.; Palchoudhury, S.; Qin, H.; Ramirez-Lugo, J.; Reithel, J.; Shaw, C. A.; Smith, A.; Smith, R.; Su
10.1101/2021.05.17.443632 — scientific communication and education — Posted on 2021-05-17
2082 Deceleration of cell cycle underpins a switch from proliferative- to terminal division in plant stomatal lineage
Han, S.-K.; Yang, J.; Arakawa, M.; Iwasaki, R.; Sakamoto, T.; Kimura, S.; Kim, E.-D.; Torii, K. U.
10.1101/2021.05.17.442671 — plant biology — Posted on 2021-05-17
2083 Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells
Wang, J.; Filippakis, H.; Hougard, T.; Du, H.; Ye, C.; Liu, H.-J.; Zhang, L.; Hindi, K.; Bagwe, S.; Nijmeh, J.; Asara, J. M.; Shi, W.; El-Chemaly, S. Y.; Henske, E. P.; Lam, H. C.
10.1101/2021.05.17.444471 — pathology — Posted on 2021-05-17
2084 Drug-induced colorectal cancer persister cells show increased mutation rate
Russo, M.; Pompei, S.; Sogari, A.; Corigliano, M.; Crisafulli, G.; Bertotti, A.; Gherardi, M.; Di Nicolantonio, F.; Bardelli, A.; Lagomarsino, M. C.
10.1101/2021.05.17.444478 — cancer biology — Posted on 2021-05-17
2086 Glucose-dependent miR-125b is a negative regulator of β-cell function
Cheung, R. W. S.; Pizza, G.; Chabosseau, P.; Rolando, D.; Tomas, A.; Burgoyne, T.; Salowka, A.; Macklin, A.; Cao, Y.; Nguyen-Tu, M.-S.; Marchetti, P.; Shapiro, J.; Piemonti, L.; de Koning, E. J. P.; Leclerc, I.; Sakamoto, K.; Smith, D. M.; Rutter, G. A.; Martinez-sanchez, A.
10.1101/2021.05.17.444559 — molecular biology — Posted on 2021-05-17
2087 Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells
Dinesh Kumar, N.; Ter Ellen, B.; Bouma, E. M.; Troost, B.; van de Pol, D. P. I.; van der Ende-Metselaar, H. H.; van Gosliga, D.; Apperloo, L.; Carpaij, O. A.; van den Berge, M.; Nawijn, M. C.; Stienstra, Y.; Rodenhuis-Zybert, I. A.; Smit, J.
10.1101/2021.05.17.444467 — microbiology — Posted on 2021-05-17
2088 Structure-based design of stabilized recombinant influenza neuraminidase tetramers
Ellis, D.; Lederhofer, J.; Acton, O. J.; Tsybovsky, Y.; Kephart, S.; Yap, C.; Gillespie, R. A.; Creanga, A.; Stephens, T.; Pettie, D.; Murphy, M.; Borst, A. J.; Park, Y.-J.; Lee, K. K.; Graham, B. S.; Veesler, D.; King, N. P.; Kanekiyo, M.
10.1101/2021.05.17.444468 — microbiology — Posted on 2021-05-17
2089 Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate
Su, D.; Li, X.; He, C.; Huang, X.; Chen, M.; Wang, Q.; Qin, W.; Liang, Y.; Xu, R.; Wu, J.; Luo, P.; Yang, X.; Zeng, Y.; Luo, M.; Luo, D.; Salisbury, D. M.; Ambrosino, D.; Siber, G.; Clemens, R.; Liang, P.; Liang, J. G.
10.1101/2021.05.16.444369 — immunology — Posted on 2021-05-17
2090 LSD flattens the brain's energy landscape: evidence from receptor-informed network control theory
Singleton, S. P.; Luppi, A. I.; Carhart-Harris, R. L.; Cruzat, J.; Roseman, L.; Deco, G.; Kringelbach, M. L.; Stamatakis, E. A.; Kuceyeski, A.
10.1101/2021.05.14.444193 — neuroscience — Posted on 2021-05-17
2093 A close-to-native structure of the synaptonemal complex
Ortiz, R.; Echeverria, O. M.; Masich, S.; Hoog, C.; Hernandez-Hernandez, A.
10.1101/2021.05.17.444495 — cell biology — Posted on 2021-05-17
2094 Verification of SARS-CoV-2-Encoded small RNAs and contribution to Infection-Associated lung inflammation
Zhang, C.; Liu, C.; Jiang, L.; Cui, B. L.; Li, Y. C.; Song, X. G.; Xu, R.; Geng, N. X.; Luan, X. C.; Chen, Y.; Zhu, L. B.; Zhu, W.
10.1101/2021.05.16.444324 — microbiology — Posted on 2021-05-17
2097 A glycan gate controls opening of the SARS-CoV-2 spike protein
Sztain, T. E.; Ahn, S.-H.; Bogetti, A. T.; Casalino, L.; Goldsmith, J. A.; Seitz, E.; McCool, R. S.; Kearns, F. L.; Acosta-Reyes, F.; Maji, S.; Mashayekhi, G.; McCammon, J. A.; Ourmazd, A.; Frank, J.; McLellan, J. S.; Chong, L.; Amaro, R. E.
10.1101/2021.02.15.431212 — biophysics — Posted on 2021-05-17
2103 Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
Prieto-Fernandez, E.; Egia-Mendikute, L.; Vila-Vecilla, L.; Bosch, A.; Barreira-Manrique, A.; Lee, S. Y.; Garcia del Rio, A.; Antonana-Vildosola, A.; Jimenez-Lasheras, B.; Moreno-Cugnon, L.; Jimenez-Barbero, J.; Berra, E.; Ereno-Orbea, J.; Palazon, A.
10.1101/2021.01.09.426021 — cell biology — Posted on 2021-05-17
2106 Neutralization potential of Covishield vaccinated individuals sera against B.1.617.1
Yadav, P.; Sapkal, G. N.; Abraham, P.; Deshpande, G.; Nyayanit, D.; Patil, D. Y.; Gupta, N.; Sahay, R. R.; Shete, A.; Kumar, S.; Panda, S.; Bhargava, B.
10.1101/2021.05.12.443645 — immunology — Posted on 2021-05-17
2107 Compensatory changes in contralesional node strength, brain wide modularity and cross-modular functional interactions in a rat model of traumatic brain injury
Yang, Z.; Zhu, T.; Pompilus, M.; Fu, Y.; Zhu, J.; Arjona, K.; Arja, R. D.; Grudny, M. M.; Plant, H. D.; Bose, P.; Wang, K. K.; Febo, M.
10.1101/2021.05.17.444382 — neuroscience — Posted on 2021-05-17
2117 Genomic contacts reveal the control of sister chromosome decatenation in E. coli
Conin, B.; Billault-Chaumartin, I.; El Sayyed, H.; Cockram, C.; Koszul, R.; Espeli, O.
10.1101/2021.05.17.444411 — molecular biology — Posted on 2021-05-17
2119 LACTATE IS A MAJOR ENERGY SUBSTRATE FOR CORTICAL NEURONS AND ENHANCES THEIR FIRING ACTIVITY
Karagiannis, A.; Gallopin, T.; Lacroix, A.; Plaisier, F.; Piquet, J.; Geoffroy, H.; Hepp, R.; Naude, J.; Le Gac, B.; Egger, R.; Lambolez, B.; Li, D.; Rossier, J.; Staiger, J. F.; Imamura, H.; Seino, S.; Roeper, J.; Cauli, B.
10.1101/2021.05.17.444414 — neuroscience — Posted on 2021-05-17
2122 Decoding Angiotensin II Type 1 Receptor Allosteric Communication to Gq and β-arrestin
Nivedha, A. K.; Cao, Y.; Lee, S.; Bhattacharya, S.; Laporte, S.; Vaidehi, N.
10.1101/2021.05.17.444454 — biophysics — Posted on 2021-05-17
2127 Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases
Neuhaus, J. D.; Wild, R.; Eyring, J.; Irobalieva, R. N.; Kowal, J.; Lin, C.-w.; Locher, K. P.; Aebi, M.
10.1101/2021.05.17.443621 — biochemistry — Posted on 2021-05-17
2128 Middle Eastern Genetic Variation Improves Clinical Annotation of the Human Genome
Ramaswamy, S.; Jain, R.; El Naofal, M.; Halabi, N.; Taylor, A.; Abou Tayoun, A.
10.1101/2021.05.15.444284 — genomics — Posted on 2021-05-17
2129 Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel
Leger, A.; Brettell, I.; Monahan, J.; Barton, C.; Wolf, N.; Kusminski, N.; Herder, C.; Aadepu, N.; Becker, C.; Gierten, J.; Hammouda, O.; Hasel, E.; Lischik, C.; Lust, K.; Tavhelidse, T.; Thumberger, T.; Tsingos, E.; Watson, P.; Welz, B.; Naruse, K.; Loosli, F.; Wittbrodt, J.; Birney, E.; Fitzgerald, T. W.
10.1101/2021.05.17.444424 — genomics — Posted on 2021-05-17
2131 Environmental DNA (eDNA) metabarcoding surveys extend the range of invasion for non-indigenous freshwater species in Eastern Europe.
Jeunen, G.-J.; Lipinskaya, T.; Gajduchenko, H.; Golovenchik, V.; Moroz, M.; Rizevsky, V.; Semenchenko, V.; Gemmell, N.
10.1101/2021.05.16.444374 — ecology — Posted on 2021-05-17
2132 Key informant perceptions on wildlife hunting in India during the COVID-19 lockdown
Mendiratta, U.; Khanyari, M.; Velho, N.; Suryawanshi, K.; Kulkarni, N. U.
10.1101/2021.05.16.444344 — ecology — Posted on 2021-05-17
2136 Restoration of DNA Integrity and Cell Cycle by Electric Stimulation in Planarian Tissues Damaged by Ionizing Radiation
Davidian, D.; LeGro, M.; Barghouth, P.; Rojas, S.; Ziman, B.; Maciel, E.; Ardell, D. H.; Escobar, A.; Oviedo, N. J.
10.1101/2021.05.16.444365 — developmental biology — Posted on 2021-05-17
2138 3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration
Newman, D.; Young, L.; Waring, T.; Brown, L.; Wolanska, K.; MacDonald, E.; Charles-Orszag, A.; Caswell, P.; Sakuma, T.; Yamamoto, T.; Machesky, L. M.; Morgan, M.; Zech, T. N.
10.1101/2021.05.17.443835 — cell biology — Posted on 2021-05-17
2147 Slow Cortical Waves via Cyclicity
Abraham, I.; Shahsavarani, B.; Zimmerman, B.; Husain, F.; baryshnikov, y.
10.1101/2021.05.16.444387 — neuroscience — Posted on 2021-05-17
2148 Mind the gap: performance metric evaluation in brain-age prediction
de Lange, A.-M. G.; Anatürk, M.; Rokicki, J.; Han, L. K. M.; Franke, K.; Alnaes, D.; Embeier, K. P.; Draganski, B.; Kaufmann, T.; Westlye, L. T.; Hahn, T.; Cole, J. H.
10.1101/2021.05.16.444349 — neuroscience — Posted on 2021-05-17
2150 High-throughput mapping of single-cell molecular and projection architecture of neurons by retrograde barcoded labelling
Xu, P.; Peng, J.; Yuan, T.; Chen, Z.; Wu, Z.; Li, T.; Li, X.; Wang, L.; Wei, W.; Li, C. T.; Luo, Z.-G.; Chen, Y.
10.1101/2021.05.16.444258 — neuroscience — Posted on 2021-05-17
2151 Differentiation of cortical brain organoids and optic nerve-like structures from retinal confluent cultures of pluripotent stem cells
Fernando, M.; Lee, S.; Wark, J. R.; Xiao, D.; Kim, H. J.; Smith, G. C.; Wong, T.; Teber, E. T.; Ali, R. R.; Yang, P.; Graham, M. E.; Gonzalez Cordero, A.
10.1101/2021.05.16.444356 — neuroscience — Posted on 2021-05-17
2152 Impaired α-tubulin re-tyrosination leads to synaptic dysfunction and is a feature of Alzheimer's disease
Peris, L.; Qu, X.; Soleilhac, J.-M.; Parato, J.; Lante, F.; Kumar, A.; Pero, M. E.; Martinez-Hernandez, J.; Corrao, C.; Falivelli, G.; Payet, F.; Gory-Faure, S.; Bosc, C.; Blanca Ramirez, M.; Sproul, A.; Brocard, J.; Di Cara, B.; Delagrange, P.; Buisson, A.; Goldberg, Y.; Moutin, M.-J.; Bartolini, F.; Andrieux, A.
10.1101/2021.05.17.443847 — neuroscience — Posted on 2021-05-17
2153 Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit
Gilbert, A.; Elorza-Vidal, X.; Rancillac, A.; Chagnot, A.; Yetim, M.; Hingot, V.; Deffieux, T.; Boulay, A.-C.; Alvear-Perez, R.; Cisternino, S.; Martin, S.; Taib, S.; Gelot, A.; Mignon, V.; Favier, M.; Brunet, I. V.; Decleves, X.; Tanter, M.; Estevez, R.; Vivien, D.; Saubamea, B.; Cohen-Salmon, M.
10.1101/2021.05.17.444434 — neuroscience — Posted on 2021-05-17
2154 Alcohol Use Disrupts Age-Appropriate Cortical Thinning in Adolescence: A Data Driven Approach
Sun, D.; Adduru, V. R.; Phillips, R. D.; Bouchard, H. C.; Sotiras, A.; Michael, A. M.; Baker, F. C.; Tapert, S. F.; Brown, S. A.; Clark, D. B.; Goldston, D.; Nooner, K. B.; Nagel, B. J.; Thompson, W. K.; De Bellis, M.; Morey, R. A.
10.1101/2021.05.17.444458 — neuroscience — Posted on 2021-05-17
2156 Processing of Pain by the Developing Brain: Evidence of Differences Between Adolescent and Adult Females
Tong, H.; Maloney, T. C.; Payne, M. F.; King, C. D.; Ting, T. V.; Kashikar-Zuck, S.; Coghill, R. C.; Lopez-Sola, M.
10.1101/2021.05.14.444209 — neuroscience — Posted on 2021-05-17
2158 Monolayer graphene-on-polymer dressings promote healing and stabilize skin temperature on acute and chronic wound models.
LE GALL, M.; SERANTONI, V.; LELOUCHE, H.; JOURDAN, F.; SIGAUDO-ROUSSEL, D.; BONOD, C.; FERRARO, S.; DAHRI-CORREIA, L.; OTHMEN, R.; BOURRIER, A.; HUROT, C.; TEOT, L.; BOUCHIAT, V.; LACAMPAGNE, A.
10.1101/2021.05.16.444337 — pharmacology and toxicology — Posted on 2021-05-17
2159 BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damage
Baker, S. C.; Mason, A. S.; Slip, R. G.; Skinner, K. T.; Macdonald, A.; Masood, O.; Harris, R. S.; Fenton, T. R.; Periyasamy, M.; Ali, S.; Southgate, J.
10.1101/2021.05.13.443803 — cancer biology — Posted on 2021-05-17
2160 The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival
Shaw, R. J.; Brun, S. N.; Lumibao, J.; Limpert, A.; Ren, H.; Ianniciello, A.; Cosford, N.; Tiriac, H.; Downes, M.; Evans, R.; Engle, D. D.
10.1101/2021.05.15.444304 — cancer biology — Posted on 2021-05-17
2161 Membrane phase separation drives organization at B cell receptor clusters
Shelby, S. A.; Castello-Serrano, I.; Wisser, K.; Levental, I.; Veatch, S.
10.1101/2021.05.12.443834 — biophysics — Posted on 2021-05-17
2163 The role of PI(4,5)P2 and synaptotagmin in membrane fusion - an in vitro study
Dietz, J.; Oelkers, M.; Hubrich, R.; Perez-Lara, A.; Jahn, R.; Steinem, C.; Janshoff, A.
10.1101/2021.05.15.444276 — biophysics — Posted on 2021-05-17
2167 Detection of fusion transcripts and their genomic breakpoints from RNA sequencing data
Hoogstrate, Y.; Komor, M. A.; Böttcher, R.; van Riet, J.; van de Werken, H. J. G.; van Lieshout, S.; Hoffmann, R.; van den Broek, E.; Bolijn, A. S.; Dits, N.; Sie, D.; van der Meer, D.; Pepers, F.; Bangma, C. H.; van Leenders, A. J. H. L.; Smid, M.; French, P. J.; Martens, J. W. M.; van Workum, W.; van der Spek, P. J.; Janssen, B.; Caldenhoven, E.; Rausch, C.; de Jong, M.; Stubbs, A. P.; Meijer, G. A.; Fijneman, R. J. A.; Jenster, G.
10.1101/2021.05.17.441778 — bioinformatics — Posted on 2021-05-17
2168 Structure-Function Relationships of the Vertebral Endplate
Wu, Y.; Morgan, E. F.-i.; Loaiza, J.; Banerji, R.; Blouin, O. R.
10.1101/2021.05.14.444250 — bioengineering — Posted on 2021-05-17
2169 High-throughput Raman-activated cell sorting in the fingerprint region
Lindley, M.; Gala de Pablo, J.; Peterson, J. W.; Isozaki, A.; Hiramatsu, K.; Goda, K.
10.1101/2021.05.16.444384 — bioengineering — Posted on 2021-05-17
2172 Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics
Harris, J. A.; Faust, B.; Gondin, A. B.; Damgen, M. A.; Suomivuori, C.-M.; Veldhuis, N. A.; Cheng, Y.; Dror, R. O.; Thal, D. M.; Manglik, A.
10.1101/2021.05.16.444192 — biochemistry — Posted on 2021-05-17
2181 Genomic Mining and Physiological Characterization of new Halophilic Plant Growth Promoting Bacilli
Petrillo, C.; Castaldi, S.; Lanzilli, M.; Selci, M.; Cordone, A.; Giovannelli, D.; Isticato, R.
10.1101/2021.05.17.444429 — microbiology — Posted on 2021-05-17
2183 Sequence and functional characterization of a public HIV-specific antibody clonotype
Raju, N.; Qin, J. S.; Fechter, E. F.; Setliff, I.; Georgiev, I. S.; Kaldine, H.; Mapengo, R.; Scheepers, C.; Morris, L.; Janowska, K.; Acharya, P.; Murji, A. A.
10.1101/2021.05.14.444191 — immunology — Posted on 2021-05-17
2185 Neuro-musculoskeletal Upper Limb in-silico asvirtual patient
Kapardi, M.; Pithapuram, M.; Iyengar, R. S.; Yashaswini, M. R.; Singh, A. K.; Sripada, S.; Raghavan, M.
10.1101/2021.05.16.444298 — neuroscience — Posted on 2021-05-17
2187 Early Detection of Tau Pathology
Parekh, P. A.; Badachhape, A.; Mu, Q.; Bhavane, R.; Srivastava, M.; Devkota, L.; Eriksen, J.; Tanifum, E.; Ghaghada, K.; Annapragada, A.
10.1101/2021.05.14.444233 — neuroscience — Posted on 2021-05-17
2189 A toolbox for efficient proximity-dependent biotinylation in zebrafish embryos
Rosenthal, S. M.; Misra, T.; Abdouni, H.; Branon, T. C.; Ting, A. Y.; Scott, I. C.; Gingras, A.-C.
10.1101/2021.05.16.444353 — systems biology — Posted on 2021-05-17
2190 Ranking Reprogramming Factors for Directed Differentiation
Hammelman, J.; Patel, T.; Closser, M.; Wichterle, H.; Gifford, D. K.
10.1101/2021.05.14.444080 — systems biology — Posted on 2021-05-17
2192 The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.
Zhu, L.; van der Pluijm, R. W.; Kucharski, M.; Nayak, S.; Tripathi, J.; Nosten, F.; Faiz, A.; Amaratunga, C.; Lek, D.; Ashley, E. A.; Smithuis, F.; Phyo, A. P.; Lin, K.; Imwong, M.; Mayxay, M.; Dhorda, M.; Chau, N. H.; Thuy, N. N. T.; Newton, P. N.; Jittamala, P.; Tripura, R.; Pukrittayakamee, S.; Peto, T. J.; Miotto, O.; Seidlein, L. v.; Hien, T. T.; Ginsburg, H.; Day, N. P.; White, N. J.; Dondorp, A. M.; Bozdech, Z.
10.1101/2021.05.17.444396 — systems biology — Posted on 2021-05-17
2197 The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells
McMahon, D. B.; Kuek, L. E.; Johnson, M. E.; Johnson, P. O.; Horn, R. L. J.; Carey, R. M.; Adappa, N. D.; Palmer, J. N.; Lee, R. J.
10.1101/2021.05.16.444376 — physiology — Posted on 2021-05-17
2200 Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer
Nekounam, H.; Dinarvand, R.; Khademi, R.; Asghari, F.; Mahmoodi, N.; Arzani, H.; Hasanzadeh, E.; Hadi, A.; Karimi, R.; Kamali, M.; Khosravani, M.
10.1101/2021.05.15.444280 — cancer biology — Posted on 2021-05-17
2202 EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities
Yedier-Bayram, O.; Gokbayrak, B.; Aksu, A. C.; Cavga, A. D.; Kayabolen, A.; Kala, E. Y.; Karabiyik, G.; Gunsay, R.; Morova, T.; Uyulur, F.; Lack, N. A.; Onder, T. T.; Bagci-Onder, T.
10.1101/2021.05.14.444239 — cancer biology — Posted on 2021-05-17
2203 Sustained Enzymatic Activity and Flow in Crowded Protein Droplets
Testa, A.; Dindo, M.; Rebane, A. A.; Nasouri, B.; Style, R. W.; Golestanian, R.; Dufresne, E. R.; Laurino, P.
10.1101/2021.05.16.444336 — biophysics — Posted on 2021-05-17
2204 Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein
Gaffney, K.; Guo, R.; Bridges, M. D.; Chen, D.; Muhammednazaar, S.; Kim, M.; yang, Z.; Schilmiller, A. L.; Faruk, N. F.; Peng, X.; Jones, A. D.; Sun, L.; Hubbell, W. L.; Sosnick, T.; Hong, H.
10.1101/2021.05.17.444377 — biophysics — Posted on 2021-05-17
2207 riboviz 2: A flexible and robust ribosome profiling data analysis and visualization workflow
Cope, A. L.; Anderson, F.; Favate, J.; Jackson, M.; Mok, A.; Kurowska, A.; MacKenzie, E.; Shivakumar, V.; Tilton, P.; Winterbourne, S. M.; Xue, S.; Kavoussanakis, K.; Lareau, L. F.; Shah, P.; Wallace, E. W.
10.1101/2021.05.14.443910 — bioinformatics — Posted on 2021-05-17
2208 Ultra-rapid somatic variant detection via real-time threshold sequencing
Wadden, J.; Newell, B.; Bugbee, J.; Dickson, R. P.; Koschmann, C.; Blaauw, D.; Narayanasamy, S.; Das, R.
10.1101/2021.05.14.444172 — bioinformatics — Posted on 2021-05-17
2210 Portable low-cost optical density meter
Puccinelli, R. R.; Cabrera, J. P.; Huynh, E.; Lebel, P. M.; Gomez-Sjoberg, R.
10.1101/2021.05.14.444207 — bioengineering — Posted on 2021-05-17
2215 Genomic context sensitivity of insulator function
Ribeiro-dos-Santos, A. M.; Hogan, M. S.; Luther, R.; Maurano, M. T.
10.1101/2021.05.16.444030 — genomics — Posted on 2021-05-17
2216 Chromosome-scale and haplotype-resolved genome assembly of a tetraploid potato cultivar
Sun, H.; Jiao, W.-B.; Krause, K.; Campoy, J. A.; Goel, M.; Folz-Donahue, K.; Kukat, C.; Huettel, B.; Schneeberger, K.
10.1101/2021.05.15.444292 — genomics — Posted on 2021-05-17
2217 The Medaka Inbred Kiyosu-Karlsruhe (MIKK) Panel
Fitzgerald, T. W.; Brettell, I.; Leger, A.; Wolf, N.; Kusminski, N.; Monahan, J.; Barton, C.; Herder, C.; Aadepu, N.; Gierten, J.; Becker, C.; Hammouda, O.; Hasel, E.; Lischik, C.; Lust, K.; Tsingos, E.; Tavhelidse, T.; Thumberger, T.; Welz, B.; Khouja, N.; Naruse, K.; Birney, E.; Wittbrodt, J.; Loosli, F.
10.1101/2021.05.17.444412 — genomics — Posted on 2021-05-17
2219 Caveolin-3 Null Mutation in Family with Barretts Esophagus and Esophageal Adenocarcinoma
Garman, K. S.; von Furstenberg, R.; Becker, T. C.; Falk, G. W.; Willis, J. E.; Dawson, D.; Guda, K.; Chak, A.
10.1101/2021.05.15.444305 — genetics — Posted on 2021-05-17
2222 Towards risk-based surveillance of African Swine Fever in Switzerland
Vargas-Amado, M. E.; Carmo, L. P.; Berezowski, J.; Fischer, C.; Santos, M. J.; Grütter, R.
10.1101/2021.05.17.444420 — ecology — Posted on 2021-05-17
2223 Climatic suitability predictions for the cultivation of macadamia in Malawi using climate change scenarios.
Zuza, E. J.; Araya, Y. N.; Maseyk, K.; Bhagwat, S. A.; de Sousa, K.; Rawes, W.; Emmott, A.
10.1101/2021.05.16.443810 — ecology — Posted on 2021-05-17
2229 Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway
Zhu, D.; Wang, Y.; Thomas, M.; McLaughlin, K.; Oguljahan, B.; Henderson, J.; Yang, Q.; Chen, Y. E.; LIU, D.
10.1101/2021.05.16.444060 — molecular biology — Posted on 2021-05-17
2230 Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in betacoronavirus replication
Ogando, N. S.; El Kazzi, P.; Posthuma, C. C. S.; Thiel, V.; Canard, B.; Ferron, F.; Decroly, E.; Snijder, E. J.
10.1101/2021.05.17.444407 — molecular biology — Posted on 2021-05-17
2232 The upper respiratory tract microbiome of Australian Aboriginal and Torres Strait Islander children in ear and nose health and disease.
Coleman, A.; Zaugg, J.; Wood, A.; Cottrell, K.; Hakansson, E. G.; Adams, J.; Brown, M.; Cervin, A.; Bialasiewicz, S.
10.1101/2021.05.13.444113 — microbiology — Posted on 2021-05-17
2233 β-lactamase remodeling and evolution of collateral resistance in hypermutator Pseudomonas aeruginosa upon long-term antibiotic therapy
Colque, C. A.; Tomatis, P. E.; Albarracin Orio, A. G.; Dotta, G.; Moreno, D. M.; Hedemann, L. G.; Hickman, R. A.; Sommer Madsen, L. M.; Feliziani, S.; Moyano, A. M.; Bonomo, R. A.; Johansen, H. K.; Molin, S.; Vila, A. J.; Smania, A. M.
10.1101/2021.05.14.444257 — microbiology — Posted on 2021-05-17
2235 T Cell Receptor Beta (TRB) Germline Variability is Revealed by Inference From Repertoire Data
Omer, A.; Peres, A.; Rodrigues, O. L.; Watson, C. T.; Lees, W.; Polak, P.; Collins, A. M.; Yaari, G.
10.1101/2021.05.17.444409 — immunology — Posted on 2021-05-17
2237 Human fetal neural stem cell-derived astrocytes maintain glutamate transport after hypoxic injury in vitro
Shrivastava, V.; Dey, D.; Singal, C. M. S.; Jaiswal, P.; Singh, A.; Sharma, J. B.; Chattopadhyay, P.; Palanichamy, J. K.; Sinha, S.; Seth, P.; Sen, S.
10.1101/2021.05.17.444180 — neuroscience — Posted on 2021-05-17
2238 Intraneuronal chloride levels encode tiredness in cortex
Alfonsa, H.; Brodersen, P.; Newey, S.; Yamagata, T.; Panayi, M. C.; Bannerman, D.; Vyazovskiy, V. V.; Akerman, C.
10.1101/2021.05.14.444189 — neuroscience — Posted on 2021-05-17
2247 Brain age predicted using graph convolutional neural network explains developmental trajectory in preterm neonates
Liu, M.; Kim, S.; Duffy, B. A.; Yuan, S.; Cole, J. H.; Toga, A. W.; Jahanshad, N.; Barkovich, A. J.; Xu, D.; Kim, H.
10.1101/2021.05.15.444320 — neuroscience — Posted on 2021-05-17
2250 Temporal and spatial topography of cell proliferation in cancer
Gaglia, G.; Kabraji, S.; Argyropoulou, D.; Dai, Y.; Wang, S.; Bergholz, J.; Coy, S.; Lin, J.-R.; Jeselsohn, R.; Metzger, O.; Winer, E. P.; Dillon, D. A.; Zhao, J. J.; Sorger, P. K.; Santagata, S.
10.1101/2021.05.16.443704 — systems biology — Posted on 2021-05-17
2254 The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster
Yoshinari, Y.; Kosakamoto, H.; Kamiyama, T.; Hoshino, R.; Matsuoka, R.; Kondo, S.; Tanimoto, H.; Nakamura, A.; Obata, F.; Niwa, R.
10.1101/2021.05.17.444252 — physiology — Posted on 2021-05-17
2257 Mammary lineage dictates homologous recombination repair and PARP inhibitor vulnerability
Kim, H.; Casey, A. E.; Palomero, L.; Mahendralingam, M.; Parsons, M.; Narala, S.; Mateo, F.; Hofer, S.; Waterhouse, P. D.; Kislinger, T.; Pujana, M. A.; Berman, H. K.; Khokha, R.
10.1101/2021.05.14.444217 — cancer biology — Posted on 2021-05-17
2259 A Novel Non-Invasive Epithelial Ovarian Cancer Mouse Model Of Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Alali, Z.; Horowitz, M. P.; Chau, D.; Trestan, L.; Hao, J.; Qi, P.; Esakov, E.; DeBernardo, R. L.; Yu, J. S.; Reizes, O.
10.1101/2021.05.16.444343 — cancer biology — Posted on 2021-05-17
2260 HOXB7 induces oncogenic transformation in NMuMG cells via JAK2-STAT3 signaling
Sakamoto, M.; Nakayama, J.; Matsui, A.; Fujimoto, J.; Goshima, N.; Watanabe, S.; Semba, K.
10.1101/2021.05.16.444388 — cancer biology — Posted on 2021-05-17
2262 Density Fluctuations Yield Distinct Growth and Fitness Effects in Single Bacteria
Nemati, S.; Singh, A.; Dhuey, S.; McDonald, A.; Weinreich, D.; Vasdekis, A. E.
10.1101/2021.05.14.444254 — biophysics — Posted on 2021-05-17
2264 OnTheFly2.0: a text-mining web application for automated biomedical entity recognition, document annotation, network and functional enrichment analysis
Baltoumas, F. A.; Zafeiropoulou, S.; Karatzas, E.; Paragkamian, S.; Thanati, F.; Iliopoulos, I.; Eliopoulos, A. G.; Schneider, R.; Jensen, L. J.; Pafilis, E.; Pavlopoulos, G. A.
10.1101/2021.05.14.444150 — bioinformatics — Posted on 2021-05-17
2268 Functional alterations in cortical processing of speech in glioma-infiltrated cortex
Aabedi, A. A.; Lipkin, B.; Kaur, J.; Kakaizada, S.; Reihl, S. J.; Young, J. S.; Lee, A. T.; Krishna, S.; Chang, E. F.; Brang, D.; Hervey-Jumper, S. L.
10.1101/2021.05.14.444263 — neuroscience — Posted on 2021-05-17
2272 The time course of molecular acclimation to seawater in a euryhaline fish
Bonzi, L. C.; Monroe, A. A.; Lehmann, R.; Berumen, M. L.; Ravasi, T.; Schunter, C.
10.1101/2021.05.17.444413 — genomics — Posted on 2021-05-17
2273 A multiple-causal-gene-cluster model underlying GWAS signals of Alzheimer's disease
Xu, M.; Liu, Q.; Bi, R.; Li, Y.; Zeng, C.; Yan, Z.; Zheng, Q.; Li, X.; Sun, C.; Ye, M.; Luo, X.-J.; Li, M.; Zhang, D.-F.; Yao, Y.-G.
10.1101/2021.05.14.444131 — genetics — Posted on 2021-05-17
2275 NeuroMechFly, a neuromechanical model of adult Drosophila melanogaster
Lobato Rios, V.; Ozdil, G. P.; Ramalingasetty, S. T.; Arreguit, J.; Ijspeert, A.; Ramdya, P.
10.1101/2021.04.17.440214 — neuroscience — Posted on 2021-05-17
2280 β-catenin perturbations control differentiation programs in mouse embryonic stem cells
Pedone, E.; Failli, M.; Gambardella, G.; De Cegli, R.; di Bernardo, D.; Marucci, L.
10.1101/2020.05.15.098137 — cell biology — Posted on 2021-05-17
2282 Revisiting Cryptococcus extracellular vesicles properties and their use as vaccine platforms
Rizzo, j.; Wong, S. S. W.; Gazi, A. D.; Moyrand, F.; Chaze, T.; Commere, P.-H.; Matondo, M.; Novault, S.; PEHAU-ARNAUDET, G.; Reis, F.; Vos, M.; Alves, L. R.; May, R. C.; Nimrichter, L. H.; Rodrigues, M. L.; AIMANIANDA, V.; Janbon, G.
10.1101/2020.08.17.253716 — microbiology — Posted on 2021-05-17
2285 Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath
Ren, X.; Wang, M.; Li, B.; Jamieson, K.; Zheng, L.; Jones, I. R.; Li, B.; Takagi, M. A.; Lee, J.; Maliskova, L.; Tam, T. W.; Yu, M.; Hu, R.; Lee, L.; Abnousi, A.; Li, G.; Li, Y.; Hu, M.; Ren, B.; Wang, W.; Shen, Y.
10.1101/2021.02.19.431931 — genomics — Posted on 2021-05-16
2287 C. elegans DSB-3 Reveals Conservation and Divergence among Protein Complexes Promoting Meiotic Double-Strand Breaks
Hinman, A. W.; Yeh, H.-Y.; Roelens, B.; Yamaya, K.; Woglar, A.; Bourbon, H.-M.; Chi, P.; Villeneuve, A. M.
10.1101/2021.05.14.444243 — genetics — Posted on 2021-05-16
2291 A hacked kitchen scale for quantification of grip strength in rodents
Homolak, J.; Virag, D.; Kodvanj, I.; Matak, I.; Babic Perhoc, A.; Knezovic, A.; Osmanovic Barilar, J.; Trkulja, V.; Salkovic-Petrisic, M.
10.1101/2020.07.23.217737 — neuroscience — Posted on 2021-05-16
2292 Suppression of PIK3CA-driven epileptiform activity by acute pathway control
Roy, A.; Han, V. Z.; Bard, A. M.; Wehle, D. T.; Smith, S. E. P.; Ramirez, J.-M.; Kalume, F.; Millen, K. J.
10.1101/2021.03.03.433821 — neuroscience — Posted on 2021-05-16
2296 SIX1 Reprograms Myogenic Transcription Factors to Maintain the Rhabdomyosarcoma undifferentiated state
Hsu, J. Y.; Danis, E. P.; Nance, S.; O'Brien, J.; Wessells, V. M.; Goodspeed, A. E.; Talbot, J. C.; Amacher, S. L.; Jedlicka, P.; Black, J. C.; Costello, J. C.; Durbin, A. D.; Artinger, K. B.; Ford, H. L.
10.1101/2021.04.25.439216 — cancer biology — Posted on 2021-05-16
2297 Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Islam, S. M. A.; Wu, Y.; Diaz-Gay, M.; Bergstrom, E. N.; He, Y.; Barnes, M.; Vella, M.; Wang, J.; Teague, J. W.; Clapham, P.; Moody, S.; Senkin, S.; Li, Y. R.; Riva, L.; Zhang, T.; Gruber, A. J.; Vangara, R.; Steele, C. D.; Otlu, B.; Khandekar, A.; Abbasi, A.; Humphreys, L.; Syulyukina, N.; Brady, S. W.; Alexandrov, B. S.; Pillay, N.; Zhang, J.; Adams, D. J.; Marticorena, I.; Wedge, D. C.; Landi, M. T.; Brennan, P.; Stratton, M. R.; Rozen, S. G.; Alexandrov, L. B.
10.1101/2020.12.13.422570 — bioinformatics — Posted on 2021-05-16
2298 Depth Dataset Using Microsoft Kinect-v2
Heravi, H.; Delgarmi, M.; Rahimpour Jounghani, A.; shahrezaie, A.; Ebrahimi, A.; Shamsi, M.
10.1101/2021.02.04.429850 — bioengineering — Posted on 2021-05-16
2300 The Unconventional Self-Cleavage of Selenoprotein K
Cheng, R.; Liu, J.; Forstner, M.; Woodward, G.; Heppard, E.; Hoffmann, P.; Rozovsky, S.
10.1101/2021.05.15.444318 — biochemistry — Posted on 2021-05-16
2301 The Role of Colony Temperature in the Entrainment of Circadian Rhythms of Honey Bee Foragers
Giannoni Guzman, M. A.; Rivera, E.; Aleman-Rios, J.; Melendez Moreno, A. M.; Perez Ramos, M.; Perez Claudio, E.; Lubirel, D.; Moore, D.; Giray, T.; Agosto Rivera, J. L.
10.1101/2020.08.17.254722 — animal behavior and cognition — Posted on 2021-05-16
2302 Integrative proteogenomics for differential expression and splicing variation in a DM1 mouse model
Solovyeva, E. M.; Utzinger, S.; Vissieres, A.; Mitchelmore, J.; Ahrne, E.; Hermes, E.; Poetsch, T.; Ronco, M.; Bidinosti, M.; Merkl, C.; Serluca, F.; Fessenden, J.; Naumann, U.; Voshol, H.; Meyer, A.; Hoersch, S.
10.1101/2021.05.15.443842 — genomics — Posted on 2021-05-16
2304 Two microbiota subtypes identified in Irritable Bowel Syndrome with distinct responses to the low FODMAP diet
Vervier, K.; Moss, S.; Kumar, N.; Adoum, A.; Barne, M.; Browne, H. P.; Kaser, A.; Kiely, C. J.; Neville, B. A.; Powell, N.; Raine, T.; Stares, M. D.; Zhu, A.; De La Revilla Negro, J.; Lawley, T. D.; Parkes, M.
10.1101/2021.05.14.444142 — microbiology — Posted on 2021-05-16
2305 Genetic targeting of Card19 is linked to disrupted Ninj1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
Bjanes, E.; Sillas, R. G.; Matsuda, R.; Demarco, B.; Fettrelet, T.; DeLaney, A. A.; Kornfeld, O. S.; Lee, B. L.; Rodriguez Lopez, E. M.; Grubaugh, D.; Wynosky-Dolfi, M. A.; Philip, N. H.; Krespan, E.; Tovar, D.; Joannas, L.; Beiting, D. P.; Henao-Mejia, J.; Schaefer, B. C.; Chen, K. W.; Broz, P.; Brodsky, I. E.
10.1101/2021.03.19.436207 — immunology — Posted on 2021-05-16
2307 A Variable Clock Underlies Internally Generated Hippocampal Sequences
Deng, X.; Chen, S.; Sosa, M.; Karlsson, M. P.; Wei, X.-X.; Frank, L. M.
10.1101/2020.04.10.035980 — neuroscience — Posted on 2021-05-16
2309 The Geometry of Concept Learning
Sorscher, B.; Ganguli, S.; Sompolinsky, H.
10.1101/2021.03.21.436284 — neuroscience — Posted on 2021-05-16
2310 Predictive evolution of metabolic phenotypes using model-designed selection niches
Jouhten, P.; Konstantinidis, D.; Pereira, F.; Andrejev, S.; Grkovska, K.; Ghiaci, P.; Beltran, G.; Almaas, E.; Mas, A.; Warringer, J.; Gonzalez, R.; Morales, P.; Patil, K. R.
10.1101/2021.05.14.443989 — systems biology — Posted on 2021-05-16
2314 Conformational buffering underlies functional selection in intrinsically disordered protein regions
Gonzalez-Foutel, N. S.; Borcherds, W. M.; Glavina, J.; Barrera-Vilarmau, S.; Sagar, A.; Estana, A.; Barozet, A.; Fernandez-Ballester, G.; Blanes-Mira, C.; Sanchez, I. E.; de Prat Gay, G.; Cortes, J.; Bernado, P.; Pappu, R. V.; Holehouse, A. S.; Daughdrill, G. W.; Chemes, L. B.
10.1101/2021.05.14.444182 — biophysics — Posted on 2021-05-16
2315 Condensin-driven loop extrusion on supercoiled DNA
Kim, E.; Gonzalez, A. M.; Pradhan, B.; van der Torre, J.; Dekker, C.
10.1101/2021.05.15.444164 — biophysics — Posted on 2021-05-16
2316 Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides
Sung, M. W.; Yang, Z.; Patton, B. L.; Mostofian, B.; Russo, J.; Zuckerman, D. M.; Shyng, S.-L.
10.1101/2021.05.15.444267 — biochemistry — Posted on 2021-05-16
2318 The quality of dissolved organic matter shapes the biogeography of the active bathypelagic microbiome
Sebastian, M.; Sanchez, P.; Salazar, G.; Alvarez-Salgado, X. A.; Reche, I.; Moran, X. A. G.; Sala, M.; Duarte, C. M.; Acinas, S. G.; Gasol, J. M.
10.1101/2021.05.14.444136 — ecology — Posted on 2021-05-16
2321 Signal Inhibitory Receptor on Leukocytes-1 recognizes S100 proteins
Rumpret, M.; von Richthofen, H. J.; van der Linden, M.; Westerlaken, G. H. A.; Talavera Ormeno, C.; Low, T. Y.; Ovaa, H.; Meyaard, L.
10.1101/2021.05.14.444196 — immunology — Posted on 2021-05-16
2322 Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression
Meednu, N.; Rangel-Moreno, J.; Zhang, F.; Escalera-Rivera, K.; Corsiero, E.; Prediletto, E.; Dicarlo, E.; Goodman, S.; Donlin, L.; Raychaudhuri, S.; Bombardieri, M.; Pitzalis, C.; Orange, D.; AMP (RA/SLE) netwrok, ; McDavid, A.; Anolik, J. H.
10.1101/2021.05.14.443150 — immunology — Posted on 2021-05-16
2323 Serine 182 on RORγt regulates T helper 17 and regulatory T cell functions to resolve inflammation
Ma, S.; Patel, S.; Chen, N.; Patel, P. R.; Cho, B. S.; Chang, J. T.; Huang, W. J. M.
10.1101/2021.05.14.444071 — immunology — Posted on 2021-05-16
2325 Short 5'UTR enables optimal translation of plant virus tricistronic RNA via leaky scanning
Fujimoto, Y.; Keima, T.; Hashimoto, M.; Hagiwara-Komoda, Y.; Hosoe, N.; Nishida, S.; Nijo, T.; Oshima, K.; Verchot, J.; Namba, S.; Yamaji, Y.
10.1101/2021.05.14.444105 — plant biology — Posted on 2021-05-16
2326 Agrobacterium-Mediated Transient Transformation of Marchantia Liverworts
Iwakawa, H.; Melkonian, K.; Schluter, T.; Nishihama, R.; Motose, H.; Nakagami, H.
10.1101/2021.05.14.444154 — plant biology — Posted on 2021-05-16
2327 Calcium signaling in the photodamaged skin
Donati, V.; Peres, C.; Nardin, C.; Scavizzi, F.; Raspa, M.; Ciubotaru, C. D.; Bortolozzi, M.; Mammano, F.
10.1101/2021.05.14.443726 — biophysics — Posted on 2021-05-16
2333 Desert fish populations tolerate extreme salinity change to overcome hydrological constraints
Schunter, C.; Bonzi, L. C.; Norstog, J.; Sourisse, J.; Berumen, M. L.; Angel, Y.; Parkes, S. D.; McCabe, M. F.; Ravasi, T.
10.1101/2021.05.14.444120 — evolutionary biology — Posted on 2021-05-16
2334 South American freshwater fish diversity shaped by Andean uplift since the Late Cretaceous
Boschman, L. M.; Cassemiro, F. A. S.; Carraro, L.; de Vries, J.; Altermatt, F.; Hagen, O.; Hoorn, C.; Pellissier, L.
10.1101/2021.05.14.444133 — evolutionary biology — Posted on 2021-05-16
2335 Pan-ErbB inhibition protects from SARS-CoV-2 replication, inflammation, and injury
Saul, S.; Karim, M.; Huang, P. T.; Ghita, L.; Chiu, W.; Kumar, S.; Bhalla, N.; Leyssen, P.; Cohen, C. A.; Huie, K. E.; Tindle, C.; Sahoo, M. K.; Sibai, M.; Pinsky, B. A.; Das, S.; Ghosh, P.; Dye, J.; Solow-Cordero, D. E.; Jin, J.; Jochmans, D.; Neyts, J.; Narayanan, A.; De Jonghe, S.; Einav, S.
10.1101/2021.05.15.444128 — microbiology — Posted on 2021-05-16
2336 Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design
Ellis, D.; Brunette, N.; Crawford, K. H. D.; Walls, A. C.; Pham, M. N.; Chen, C.; Herpoldt, K.-L.; Fiala, B.; Murphy, M.; Pettie, D.; Kraft, J. C.; Malone, K. D.; Navarro, M. J.; Ogohara, C.; Kepl, E.; Ravichandran, R.; Sydeman, C.; Ahlrichs, M.; Johnson, M.; Blackstone, A.; Carter, L.; Starr, T. N.; Greaney, A. J.; Lee, K. K.; Veesler, D.; Bloom, J. D.; King, N. P.
10.1101/2021.05.15.444222 — microbiology — Posted on 2021-05-16
2337 Allicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome
Mösbauer, K.; Fritsch, V. N.; Adrian, L.; Bernhardt, J.; Gruhlke, M. C. H.; Slusarenko, A. J.; Niemeyer, D.; Antelmann, H.
10.1101/2021.05.15.444275 — microbiology — Posted on 2021-05-16
2339 Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants
Pegu, A.; O'Connell, S. E.; Schmidt, S. D.; O'Dell, S.; Talana, C. A.; Lai, L.; Albert, J.; Anderson, E.; Bennett, H.; Corbett, K.; Flach, B.; Jackson, L.; Leav, B.; Ledgerwood, J. E.; Luke, C. J.; Makowski, M.; Roberts, P. C.; Roederer, M.; Rebolledo, P. A.; Rostad, C. A.; Rouphael, N. G.; Shi, W.; Wang, L.; Widge, A. T.; Yang, E. S.; Beigel, J. H.; Graham, B. S.; Mascola, J. R.; Suthar, M. S.; McDermott, A.; Doria-Rose, N. A.
10.1101/2021.05.13.444010 — immunology — Posted on 2021-05-16
2340 Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition
Kramer, K. J.; Johnson, N. V.; Shiakolas, A. R.; Suryadevara, N.; Periasamy, S.; Raju, N.; Williams, J. K.; Wrapp, D.; Zost, S. J.; Holt, C. M.; Hsieh, C.-L.; Sutton, R. E.; Paulo, A.; Davidson, E.; Doranz, B. J.; Crowe, J. E.; Bukreyev, A.; Carnahan, R. H.; McLellan, J. S.; Georgiev, I. S.
10.1101/2021.05.16.444004 — immunology — Posted on 2021-05-16
2341 CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes
Djekidel, M. N.; Rosikiewicz, W.; Peng, J. C.; Kanneganti, T.-D.; Hui, Y.; Jin, H.; Hedges, D.; Schreiner, P.; Fan, Y.; Wu, G.; Xu, B.
10.1101/2021.05.14.444026 — bioinformatics — Posted on 2021-05-16
2343 Cytokinin inhibits fungal development and virulence by targeting cellular trafficking
Gupta, R.; Anand, G.; Pizarro, L.; Laor, D.; Kovetz, N.; Sela, N.; Yehuda, T.; Gazit, E.; Bar, M.
10.1101/2020.11.04.369215 — microbiology — Posted on 2021-05-16
2344 Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.
Steg, L. C.; Shireby, G. L.; Imm, J.; Davies, J. P.; Franklin, A.; Flynn, R.; Namboori, S. C.; Bhinge, A.; Jeffries, A. R.; Burrage, J.; Neilson, G. W. A.; Walker, E. M.; Perfect, L. W.; Price, J.; McAlonan, G.; Srivastava, D. P.; Bray, N. J.; Cope, E. L.; Jones, K. M.; Allen, N. D.; Pishva, E.; Dempster, E. L.; Lunnon, K.; Mill, J.; Hannon, E.
10.1101/2020.10.14.339093 — neuroscience — Posted on 2021-05-16
2345 Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies
Gale-Grant, O.; Fenn-Moltu, S.; Franca, L.; Dimitrova, R.; Christiaens, D.; Cordero-Grande, L.; Chew, A.; Falconer, S.; Harper, N.; Price, A. N.; Hutter, J.; Hughes, E.; O'Muircheartaigh, J.; Rutherford, M.; Counsell, S.; Rueckert, D.; Nosarti, C.; Hajnal, J. V.; McAlonan, G.; Arichi, T.; Edwards, A. D.; Batalle, D.
10.1101/2021.05.02.442327 — neuroscience — Posted on 2021-05-16
2346 Stable choice coding during changes of mind
Boyd-Meredith, J. T.; Piet, A. T.; Dennis, E. J.; El Hady, A.; Brody, C.
10.1101/2021.05.13.444020 — neuroscience — Posted on 2021-05-16
2349 A Trifector of New Insights into Ovine Footrot for Infection Drivers, Immune Response and Host Pathogen Interactions
Blanchard, A. M.; staley, C. E.; Shaw, L.; Wattegedera, S.; Baumbach, C. M.; Michler, J. K.; Rutland, C.; Back, C.; Newbold, N.; Entrican, G.; Tötemeyer, S.
10.1101/2021.05.13.444115 — genomics — Posted on 2021-05-16
2350 Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles
Sitarska, E.; Dias Almeida, S.; Beckwith, M.; Stopp, J.; Schwab, Y.; Sixt, M.; Kreshuk, A.; Erzberger, A.; Diz-Munoz, A.
10.1101/2021.03.26.437199 — cell biology — Posted on 2021-05-16
2351 A divergent protein kinase A in the human pathogen Leishmania is associated with developmental morphogenesis
Fischer-Weinberger, R.; Bachmaier, S.; Dandugudumuoa, R.; Phan, I. Q.; Almoznino, M.; Githure, G. B.; Polatoglou, E.; Tsigankove, P.; Nitzan Koren, R.; Myler, P. J.; Boshart, M. J.; Zilberstein, D.
10.1101/2021.04.24.440790 — cell biology — Posted on 2021-05-16
2356 Microinductor-Fused Atomic Force Microscopy Cantilevers for Dynamic Imaging and Multimodal Manipulation
Mousoulis, H.; Xu, X.; Wilson, R.; Chado, G.; Wahlquist, J.; Stoykovich, M.; Ferguson, V.; Ziaie, B.; Neu, C.
10.1101/2021.05.13.444109 — biophysics — Posted on 2021-05-16
2358 Height, but not binding epitope, affects the potency of synthetic TCR agonists
Wilhelm, K. B.; Morita, S.; McAffee, D. B.; Kim, S.; O'Dair, M. K.; Groves, J. T.
10.1101/2021.05.13.443919 — biophysics — Posted on 2021-05-16
2359 Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbations
Patel, T.; Carnwath, T. P.; Wang, X.; Allen, M.; Lincoln, S. J.; Lewis-Tuffin, L. J.; Quicksall, Z. S.; Lin, S.; Tutor-New, F. Q.; Ho, C. C.; Min, Y.; Malphrus, K. G.; Nguyen, T. T.; Martin, E.; Garcia, C. A.; Alkharboosh, R. M.; Grewal, S.; Chaichana, K.; Wharen, R.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Ertekin-Taner, N.
10.1101/2021.05.13.444000 — genetics — Posted on 2021-05-16
2363 Expression of GRINA Correlates with Prognosis in Human Cancers: A Pan-cancer Analysis
Islam, S. M. R.; Saha, S. K.; El-Sappagh, S.; Tariq, F.; Das, J.; Afzal, M.; Cho, S.-G.
10.1101/2021.05.13.444089 — cancer biology — Posted on 2021-05-16
2365 The FDA-approved drug apremilast suppresses alcohol intake: clinical and pre-clinical validation
Grigsby, K. B.; Mangieri, R. A.; Roberts, A. J.; Lopez, M. J.; Tran, A.; Firsick, E. J.; Townsley, K. G.; Beneze, A.; Bess, J.; Eisenstein, T. K.; Meissler, J. J.; Light, J. M.; Miller, J.; Quello, S.; Shadan, F.; Skinner, M.; Aziz, H. C.; Metten, P.; Morissett, R. A.; Crabbe, J. C.; Roberto, M.; Becker, H. C.; Mason, B. J.; Ozburn, A. R.
10.1101/2021.05.13.444033 — animal behavior and cognition — Posted on 2021-05-15
2366 Insularity forcing on plant persistence strategies in edaphic island systems
Conti, L.; Mendez-Castro, F. E.; Chytry, M.; Goetzenberger, L.; Hajek, M.; Horsak, M.; Jimenez-Alfaro, B.; Klimesova, J.; Zeleny, D.; Ottaviani, G.
10.1101/2021.05.13.444066 — ecology — Posted on 2021-05-15
2367 Distant water industrial fishing in developing countries: A case study of Madagascar
White, E. R.; Baker-Medard, M.; Vakhitova, V. K.; Farquhar, S.; Ramaharitra, T. T.
10.1101/2021.05.13.444019 — ecology — Posted on 2021-05-15
2368 SETDB1 regulates microtubule dynamics
Hernandez-Vicens, R.; Pernicone, N.; Listovsky, T.; Gerlitz, G.
10.1101/2021.05.15.444210 — cell biology — Posted on 2021-05-16
2369 Localization and RNAi-driven inhibition of a Brugia malayi encoded Interleukin-5 Receptor Binding protein
Mejia, R.; Bennuru, S.; Oksov, Y.; Lustigman, S.; Munirathinam, G.; Kalyanasundaram, R.; Nutman, T. B.
10.1101/2021.05.13.443627 — molecular biology — Posted on 2021-05-15
2370 Safety, immunogenicity and protection provided by unadjuvanted and adjuvanted formulations of recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in non-human primates
Pillet, S.; Arunachalam, P. S.; Andreani, G.; Golden, N.; Fontenot, J.; Aye, P.; Röltgen, K.; Lehmick, G.; Dube, C.; Gobeil, P.; Trepanier, S.; Charland, N.; D'Aoust, M.-A.; Russell-Lodrigue, K.; Blair, R. V.; Boyd, S.; Bohm, R. B.; Rappaport, J.; Villinger, F.; Ward, B. J.; Pulendran, B.; Landry, N.
10.1101/2021.05.15.444262 — immunology — Posted on 2021-05-15
2371 Fc-independent neutralization of SARS-CoV-2 by recombinant human monoclonal antibodies
Noy-Porat, T.; Edri, A.; Alcalay, R.; Makdasi, E.; Gur, D.; Aftalion, M.; Evgy, Y.; Beth-Din, A.; Levy, Y.; Epstein, E.; Radinsky, O.; Zauberman, A.; Lazar, S.; Yitzhaki, S.; Marcus, H.; Porgador, A.; Rosenfeld, R.; Mazor, O.
10.1101/2021.05.15.443978 — immunology — Posted on 2021-05-15
2372 Stable choice coding during changes of mind
Boyd-Meredith, J. T.; Piet, A. T.; Dennis, E. J.; El Hady, A.; Brody, C.
10.1101/2021.05.13.444020 — neuroscience — Posted on 2021-05-15
2375 How ancient forest fragmentation and riparian connectivity generate high levels of genetic diversity in a micro-endemic Malagasy tree
Salmona, J.; Dresen, A.; Ranaivoson, A. E.; Manzi, S.; Le Pors, B.; Hong-Wa, C.; Razanatsoa, J.; Andriaholinirina, N. V.; Rasoloharijaona, S.; Vavitsara, M.-E.; Besnard, G.
10.1101/2020.11.25.394544 — genomics — Posted on 2021-05-15
2376 Evolutionary assembly of cooperating cell types in an animal chemical defense system
Bruckner, A.; Badroos, J.; Learsch, R. W.; Yousefelahiyeh, M.; Kitchen, S. A.; Parker, J.
10.1101/2021.05.13.444042 — evolutionary biology — Posted on 2021-05-15
2379 Lung Epithelial Cells Can Produce Antibodies Participating In Adaptive Humoral Immune Responses
Gao, E.; Shao, W.; Zhang, C.; Yu, M.; Dai, H.; Fan, T.; Zhu, Z.; Xu, W.; Huang, J.; Zhang, Y.; Qin, Z.; Qiu, X.
10.1101/2021.05.13.443498 — immunology — Posted on 2021-05-15
2385 Time-resolved scanning ion conductance microscopy for three-dimensional tracking of nanoscale cell surface dynamics
Leitao, S. M.; Drake, B.; Pinjusic, K.; Pierrat, X.; Navikas, V.; Nievergelt, A. P.; Brillard, C.; Djekic, D.; Radenovic, A.; Persat, A.; Constam, D. B.; Anders, J.; Fantner, G. E.
10.1101/2021.05.13.444009 — biophysics — Posted on 2021-05-15
2391 Microtubule re-organization during female meiosis in C. elegans
Lantzsch, I.; Yu, C.-H.; Chen, Y.-Z.; Zimyanin, V.; Yazdhkasti, H.; Lindow, N.; Pani, A.; Szentgyoergyi, E.; Prohaska, S.; Srayko, M.; Fuerthauer, S.; Redemann, S.
10.1101/2020.05.14.095984 — cell biology — Posted on 2021-05-15
2395 Introduction of Surface Loops as a Tool for Encapsulin Functionalization.
Michel-Souzy, S.; Hamelmann, N. M.; Zarzuela-Pura, S.; Paulusse, J. M. J.; Cornelissen, J. J. L. M.
10.1101/2021.05.13.444092 — bioengineering — Posted on 2021-05-15
2397 Liquid-Liquid Phase Separation Protects Amyloidogenic and Aggregation-Prone Peptides in Heterologous Expression Systems
Gabryelczyk, B.; Philips, M.; Low, K.; Venkatraman, A.; Kannaian, B.; Alag, R.; Linder, M.; Pervushin, K.; Miserez, A.
10.1101/2021.05.14.443401 — molecular biology — Posted on 2021-05-15
2398 S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy
Brody, M. J.; Baldwin, T. A.; Subramani, A.; Kanisicak, O.; Vagnozzi, R. J.; Molkentin, J. D.
10.1101/2021.05.14.444015 — molecular biology — Posted on 2021-05-15
2399 Zika virus infection of pregnant Ifnar1-/- mice triggers strain-specific differences in fetal outcomes
Bohm, E. K.; Vangorder-Braid, J. T.; Jaeger, A. S.; Moriarty, R. V.; Baczenas, J. J.; Bennett, N. C.; O'Connor, S. L.; Fritsch, M. K.; Fuhler, N. A.; Noguchi, K. K.; Aliota, M.
10.1101/2021.05.14.444269 — microbiology — Posted on 2021-05-15
2400 Human norovirus infection of primary B cells triggers immune activation in vitro
Mirabelli, C.; Jones, M. K.; Young, V.; Kolawole, A.; Owusu, I.; Shan, M.; Abuaita, B. H.; Grigorova, I.; Lundy, S. K.; Lyssiotis, C. A.; Ward, V. K.; Karst, S. M.; Wobus, C. E.
10.1101/2021.05.14.444272 — microbiology — Posted on 2021-05-15
2401 "Adopt a Microorganism" methodology enhances the discourse richness of high school students in both hybrid learning and remote education
Rodrigues Cintra Armellini, B.; La Luna, A.; Bueris, V.; Pinto de Almeida, A.; Moraes Tamais, A.; Krzyzanowski Junior, F.; Hasten Reiter, V. S.; Lellis-Santos, C.; Cafe Ferreira, R. d. C.
10.1101/2021.03.09.434548 — scientific communication and education — Posted on 2021-05-15
2402 Transcriptomic profiling of human orbital fat and differentiating orbital fibroblasts
Kim, D. W.; Taneja, K.; Hoang, T.; Santiago, C. P.; McCulley, T. J.; Merbs, S. L.; Mahoney, N. R.; Blackshaw, S.; Rajaii, F.
10.1101/2021.05.13.443857 — molecular biology — Posted on 2021-05-15
2403 The amino acid substitution affects cellular response to mistranslation
Berg, M. D.; Zhu, Y.; Ruiz, B. Y.; Loll-Krippleber, R.; Isaacson, J.; San Luis, B.-J.; Genereaux, J.; Boone, C.; Villen, J.; Brown, G. W.; Brandl, C. J.
10.1101/2021.05.12.443880 — molecular biology — Posted on 2021-05-15
2404 Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent malaria treatment
Hosch, S.; Yoboue, C. A.; Donfack, O. T.; Guirou, E. A.; Dangy, J.-P.; Mpina, M.; Nyakurungu, E.; Blöchliger, K.; Guerra, C. A.; Phiri, W. P.; Ayekaba, M. O.; Garcia, G.; Tanner, M.; Daubenberger, C.; Schindler, T.
10.1101/2021.05.12.443950 — microbiology — Posted on 2021-05-15
2405 Assessing antibiotic tolerance of Staphylococcus aureus derived directly from patients by the Replica Plating Tolerance Isolation System- REPTIS
Herren, S.; Huemer, M.; Acevedo, C. T.; Andreoni, F.; Gomez Mejia, A.; Mairpady Shambat, S.; Hasse, B. K.; Zbinden, R.; Brugger, S. D.; Zinkernagel, A. S.
10.1101/2021.05.12.443951 — microbiology — Posted on 2021-05-15
2406 Metagenomic sequencing for rapid identification of Xylella fastidiosa from leaf samples
Roman-reyna, V.; Dupas, E.; Cesbron, S.; Marchi, G.; Campigli, S.; Hansen, M. A.; Bush, E.; Prarat, M.; Shiplett, K.; Ivey, M. L. L.; Pierzynski, J.; Miller, S. A.; Peduto Hand, F.; Jacques, M.-A.; Jacobs, J. M.
10.1101/2021.05.12.443947 — microbiology — Posted on 2021-05-15
2407 Toxoplasma gondii Toxolysin 4 contributes to efficient parasite egress from host cells
Huynh, M.-H.; Roiko, M.; Gomes, A.; Schinke, E. N.; Schultz, A. J.; Agrawal, S.; Olleig, C. A.; Sexton, T. R.; Beauchamp, J. M.; Laliberte, J.; Sivaraman, K. K.; Hersh, L. B.; McGowan, S.; Carruthers, V. B.
10.1101/2021.05.13.444112 — microbiology — Posted on 2021-05-15
2408 SAR11 Cells Rely on Enzyme Multifunctionality to Transport and Metabolize a Range of Polyamine Compounds
Noell, S. E.; Barrell, G. E.; Suffridge, C.; Morre, J. T.; Gable, K. P.; Graff, J. R.; VerWey, B. J.; Hellweger, F. L.; Giovannoni, S. J.
10.1101/2021.05.13.444117 — microbiology — Posted on 2021-05-15
2409 CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants
Chen, Z.-N.; Zhu, P.; Bian, H.; Geng, J.; Chen, L.; Yuan, Y.; Chen, R.; Wang, K.; Deng, Y.; Du, P.; Liu, J.; Wu, G.; Wang, Y.; Sun, X.; Guo, T.; Yang, X.; Wu, J.; Jiang, J.; Li, L.; Zhang, K.; Zhu, H.; Zheng, Z.; Fu, X.; Yang, F.; Chen, X.; Tang, H.; Zhang, Z.; Wei, D.; Zhang, Y.; Shi, Y.; Zhu, Y.; Pei, Z.; Huo, F.; Chen, S.; Wang, Q.; Xie, W.; Li, Y.
10.1101/2021.05.14.444111 — immunology — Posted on 2021-05-15
2411 Monocyte-derived transcriptome signature indicates antibody-dependent cellular 1 phagocytosis as the primary mechanism of vaccine-induced protection against HIV-1
Shangguan, S.; Ehrenberg, P. K.; Geretz, A.; Yum, L.; Kundu, G.; May, K.; Fourati, S.; Nganou-Makamdop, k.; Williams, L. D.; Sawant, S.; Lewitus, E.; Pitisuttithum, P.; Nitayaphan, S.; Chariyalertsak, S.; Rerks-Ngarm, S.; Rolland, M.; Douek, D. C.; Gilbert, P.; Tomaras, G. D.; Michael, N. L.; Vasan, S.; Thomas, R.
10.1101/2021.05.12.443737 — systems biology — Posted on 2021-05-15
2412 Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate
Holmes, J. B.; Liu, V.; Caulkins, B. G.; Hilario, E.; Ghosh, R. K.; Drago, V. N.; Young, R. P.; Romero, J.; Gill, A. D.; Bogie, P. M.; Paulino, J.; Wang, X.; Riviere, G.; Bosken, Y. K.; Struppe, J.; Hassan, A.; Guidoulianov, J.; Perrone, B.; Chang, C.-e. A.; Vigier, F. M.-; Long, J. R.; Hooley, R. J.; Mueser, T. C.; Dunn, M. F.; Mueller, L. J.
10.1101/2021.05.12.443852 — biophysics — Posted on 2021-05-15
2413 Host transcriptional response to SARS-CoV-2 infection in COVID-19 patients
Singh, N. K.; Srivastava, S.; Zaveri, L.; Bingi, T. C.; Mesipogu, R.; Kumar, S.; Gaur, N.; Hajirnis, N.; Maccha, P.; Shambhavi, S.; Khan, S.; Soujanya, M.; Nagabandi, T.; Mishra, R. K.; Tallapaka, K. B.; Sowpati, D. T.
10.1101/2021.05.13.443721 — bioinformatics — Posted on 2021-05-15
2414 Human immunocompetent Choroid-on-Chip: a novel tool for studying ocular effects of biological drugs
Cipriano, M.; Schluender, K.; Probst, C.; Linke, K.; Weiss, M.; Fischer, M. J.; Mesch, L.; Achberger, K.; Liebau, S.; Mesquida, M.; Nicolini, V.; Schneider, A.; Giusti, A. M.; Kustermann, S.; Loskill, P.
10.1101/2021.05.12.443846 — bioengineering — Posted on 2021-05-15
2415 New cellular models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor
Bhalla, A. D.; Landers, S. M.; Singh, A. K.; Yeagley, M. G.; Meyerson, G. S. B.; Mulder, Z. A.; Delgado-Baez, C. B.; Dunnand, S.; Kochat, V.; Tomczak, K. J.; Nguyen, T.; Ma, X.; Bolshakov, S.; Menegaz, B. A.; Lamhamedi-Cherradi, S.-E.; Ludwig, J. A.; Beird, H. C.; Mao, X.; Song, X.; Ingram, D. R.; Wang, W.-L.; Lazar, A. J.; McCutcheon, I. E.; Slopis, J. M.; Rai, K.; Zhang, J.; Lev, D. C.; Torres, K. E.
10.1101/2021.05.13.443902 — cancer biology — Posted on 2021-05-15
2416 A Variable Clock Underlies Internally Generated Hippocampal Sequences
Deng, X.; Chen, S.; Sosa, M.; Karlsson, M. P.; Wei, X.-X.; Frank, L. M.
10.1101/2020.04.10.035980 — neuroscience — Posted on 2021-05-15
2419 Kappa but not delta or mu opioid receptors form homodimers at low membrane densities
Cechova, K.; Lan, C.; Macik, M.; Barthes, N. P. F.; Jung, M.; Ulbrich, M. H.
10.1101/2020.03.22.002394 — biochemistry — Posted on 2021-05-15
2420 Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
Owens, D. D. G.; Anselmi, G.; Oudelaar, A. M.; Downes, D. J.; Cavallo, A.; Harman, J. R.; Schwessinger, R.; Bucakci, A.; Greder, L.; De Ornellas, S.; Jeziorska, D.; Telenius, J.; Hughes, J. R.; de Bruijn, M. F. T. R.
10.1101/2021.05.14.444178 — developmental biology — Posted on 2021-05-15
2421 A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
Robertson, N.; Shchepachev, V.; Wright, D.; Turowski, T. W.; Spanos, C.; Helwak, A.; Zamoyska, R.; Tollervey, D.
10.1101/2021.03.29.437572 — cell biology — Posted on 2021-05-15
2426 Mesothelial cells are not a source of adipocytes in mice
Westcott, G.; Emont, M.; Li, J.; Jacobs, C.; Tsai, L.; Rosen, E.
10.1101/2021.05.13.444022 — developmental biology — Posted on 2021-05-15
2428 A chemotactic sensor controls Salmonella-host cell interaction
Hoffmann, S.; Gendera, K.; Schmidt, C.; Kirchweger, P.; Imhof, A.; Bogdan, C.; Muller, Y. A.; Hensel, M.; Gerlach, R. G.
10.1101/2021.05.14.443827 — microbiology — Posted on 2021-05-15
2430 A Novel Pharmacogenetic Model for Highly Efficient Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS
Xing, Y. L.; Chuang, B. H. A.; Poh, J.; Moradi, K.; Mitew, S.; Kilpatrick, T. J.; Osanai, Y.; Merson, T. D.
10.1101/2021.05.13.443012 — neuroscience — Posted on 2021-05-15
2431 Neuronal NADPH oxidase in Parkinson disease pathogenesis
Keeney, M. T.; Hoffman, E. K.; Farmer, K.; Bodle, C. R.; Fazzari, M.; Zharikov, A.; Castro, S. L.; Kofler, J. K.; Cifuentes-Pagano, E.; Pagano, P. J.; Burton, E. A.; Hastings, T. G.; Greenamyre, J. T.; Di Maio, R.
10.1101/2021.05.13.443999 — neuroscience — Posted on 2021-05-15
2432 The EphB2-MYC Axis is a Major Determinant of Barrett's Pathobiology and a Therapeutic Vulnerability in Esophageal Cancer
Venkitachalam, S.; Babu, D.; Ravillah, D.; Katabathula, R. M.; Joseph, P.; Singh, S.; Udhayakumar, B.; Miao, Y.; Martinez-Uribe, O.; Hogue, J. A.; Kresak, A. M.; Dawson, D.; LaFramboise, T.; Willis, J. E.; Chak, A.; Garman, K. S.; Blum, A. E.; Varadan, V.; Guda, K.
10.1101/2021.05.13.444044 — cancer biology — Posted on 2021-05-15
2433 Label-free super-resolution chemical imaging of biomedical specimens
Guilbert, J.; Negash, A.; Labouesse, S.; Gigan, S.; Sentenac, A.; B de Aguiar, H.
10.1101/2021.05.14.444185 — biophysics — Posted on 2021-05-15
2434 An ultrasensitive method for analysis of viral spike N-glycoforms
Baboo, S.; Diedrich, J. K.; Martinez-Bartolome, S.; Wang, X.; Schiffner, T.; Groschel, B.; Schief, W. R.; Paulson, J. C.; Yates, J. R.
10.1101/2021.05.13.444041 — biochemistry — Posted on 2021-05-15
2435 Lack of food intake during shift work alters the heart transcriptome and leads to cardiac fibrosis and inflammation in rats
Trott, A. J.; Greenwell, B. J.; Karhadkar, T. J.; Guerrero-Vargas, N. N.; Escobar, C.; Buijs, R. M.; Menet, J. S.
10.1101/2021.05.13.444001 — genomics — Posted on 2021-05-15
2436 The effects of host availability and fitness on Aedes albopictus blood feeding patterns in New York
Fikrig, K. M.; Martin, E.; Dang, S.; St Fleur, K.; Goldsmith, H.; Qu, S.; Rosenthal, H.; Pitcher, S.; Harrington, L. C.
10.1101/2021.05.13.443995 — ecology — Posted on 2021-05-15
2438 Hypoxia induces transcription of DOT1L in articular cartilage to protect against osteoarthritis
De Roover, A.; Escribano, A.; Cornelis, F.; Cherifi, C.; Casas-Fraile, L.; Sermon, A.; Cailotto, F.; Lories, R.; Monteagudo, S.
10.1101/2021.05.14.444225 — cell biology — Posted on 2021-05-15
2440 Insights into the secondary and tertiary structure of the Bovine Viral Diarrhea Virus Internal Ribosome Entry Site
Gosavi, D.; Wower, I.; Beckmann, I.; Hofacker, I. L.; Wower, J.; Wolfinger, M. T.; Sztuba-Solinska, J.
10.1101/2021.05.13.444024 — microbiology — Posted on 2021-05-15
2444 A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart
Ranea-Robles, P.; Pavlova, N. N.; Bender, A.; Stauffer, B.; Yu, C.; Thompson, C. B.; Argmann, C.; Puchowicz, M. A.; Houten, S. M.
10.1101/2021.05.13.443905 — physiology — Posted on 2021-05-15
2447 Fast-spiking interneurons of the premotor cortex contribute to action planning
Giordano, N.; Alia, C.; Fruzzetti, L.; Pasquini, M.; Micera, S.; Mazzoni, A.; Fogassi, L.; Bonini, L.; Caleo, M.
10.1101/2021.05.14.443822 — physiology — Posted on 2021-05-14
2448 Evidence Of We-Representation In Monkeys When Acting Together
Lacal, I.; Babicola, L.; Caminiti, R.; Ferrari-Toniolo, S.; Schito, A.; Nalbant, L. E.; Gupta, R. K.; Battaglia-Mayer, A.
10.1101/2021.05.14.444171 — animal behavior and cognition — Posted on 2021-05-14
2451 PQN-59 antagonizes microRNA-mediated repression and functions in stress granule formation during C. elegans development
Hammell, C. M.; Carlston, C.; Weinmann, R.; Stec, N.; Abbatemarco, S.; Schwager, F.; Wang, J.; Ouyang, H.; Gotta, M.
10.1101/2021.05.14.444139 — developmental biology — Posted on 2021-05-14
2453 Large-scale deployment and establishment of Wolbachia into the Aedes aegypti population in Rio de Janeiro, Brazil.
Gesto, J. S. M.; Pinto, S.; Dias, F. B. S.; Peixoto, J.; Costa, G.; Kutcher, S.; Montgomery, J.; Green, B. R.; Anders, K. L.; Ryan, P. A.; Simmons, C. P.; O'Neill, S. L.; Moreira, L. A.
10.1101/2021.04.29.441982 — microbiology — Posted on 2021-05-14
2454 Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Nightingale, K.; Fielding, C. A.; Zerbe, C.; Hunter, L.; Potts, M.; Fletcher-Etheringon, A.; Nobre, L.; Wang, E. C. Y.; Strang, B. L.; Houghton, J.; Antrobus, R.; Suarez, N. M.; Nichols, J.; Davison, A. J.; Stanton, R. J.; Weekes, M. P.
10.1101/2021.05.14.444170 — microbiology — Posted on 2021-05-14
2456 Molecular diversity and lineage commitment of human interneuron progenitors
Velmeshev, D.; Chavali, M.; Nowakowski, T. J.; Bhade, M.; Mayer, S.; Goyal, N.; Alvarado, B.; Mancia, W.; Wang, S.; Speir, M.; Haeussler, M. J.; Rowitch, D.; Alvarez-Buylla, A.; Huang, E.; Paredes, M.; Kriegstein, A.
10.1101/2021.05.13.444045 — neuroscience — Posted on 2021-05-14
2458 Transcribed enhancers in the human brain identify novel disease risk mechanisms
Dong, P.; Hoffman, G. E.; Apontes, P.; Bendl, J.; Rahman, S.; Fernando, M. B.; Zeng, B.; Vicari, J. M.; Zhang, W.; Girdhar, K.; Townsley, K. G.; Misir, R.; the CommonMind Consortium, ; Brennand, K. J.; Haroutunian, V.; Voloudakis, G.; Fullard, J. F.; Roussos, P.
10.1101/2021.05.14.443421 — neuroscience — Posted on 2021-05-14
2459 Scalable mapping of myelin and neuron density in the human brain with micrometer resolution
Wang, H.; Chang, S.; Varadarajan, D.; Yang, J.; Chen, I. A.; Kura, S.; Magnain, C.; Augustinack, J. C.; Fischl, B.; Greve, D. N.; Boas, D. A.
10.1101/2021.05.13.444005 — neuroscience — Posted on 2021-05-14
2461 Human islet expression levels of Prostaglandin E2 synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesity
Truchan, N. A.; Fenske, R. J.; Sandhu, H. K.; Weeks, A. M.; Patibandla, C.; Wancewicz, B.; Pabich, S.; Reuter, A.; Harrington, J. M.; Brill, A. L.; Peter, D. C.; Nall, R.; Daniels, M.; Punt, M.; Kaiser, C. E.; Cox, E. D.; Ge, Y.; Davis, D. B.; Kimple, M. E.
10.1101/2021.02.03.429205 — pharmacology and toxicology — Posted on 2021-05-14
2462 CSI-Microbes: Identifying cell-type specific intracellular microbes from single-cell RNA-seq data
Robinson, W.; Schischlik, F.; Gertz, E. M.; Lee, J. S.; Zhu, K.; Sahinalp, C.; Patro, R.; Leiserson, M. D.; Schäffer, A. A.; Ruppin, E.
10.1101/2020.05.14.096230 — cancer biology — Posted on 2021-05-14
2463 Clusterin in Alzheimer's disease: an amyloidogenic inhibitor of amyloid formation
Spatharas, P. M.; Nasi, G. I.; Tsiolaki, P. L.; Theodoropoulou, M. K.; Papandreou, N. C.; Hoenger, A.; Trougakos, I. P.; Iconomidou, V. A.
10.1101/2021.04.02.438207 — biophysics — Posted on 2021-05-14
2464 A platform for deep sequence-activity mapping and engineering antimicrobial peptides
DeJong, M. P.; Ritter, S. C.; Fransen, K. A.; Tresnak, D. T.; Golinski, A. W.; Hackel, B. J.
10.1101/2021.05.13.444096 — bioengineering — Posted on 2021-05-14
2468 A single N6-methyladenosine site in lncRNA HOTAIR regulates its function in breast cancer cells
Porman, A. M.; Roberts, J. T.; Duncan, E. D.; Chrupcala, M.; Levine, A.; Kennedy, M.; Williams, M. M.; Richer, J. K.; Johnson, A. M.
10.1101/2020.06.08.140954 — molecular biology — Posted on 2021-05-14
2470 Archival influenza virus genomes from Europe reveal genomic and phenotypic variability during the 1918 pandemic
Patrono, L. V.; Vrancken, B.; Budt, M.; Duex, A.; Lequime, S.; Boral, S.; Gilbert, M. T. P.; Gogarten, J. F.; Hoffmann, L.; Horst, D.; Merkel, K.; Morens, D.; Prepoint, B.; Schlotterbeck, J.; Schuenemann, V.; Suchard, M. A.; Taubenberger, J. K.; Tenkhoff, L.; Urban, C.; Widulin, N.; Winter, E.; Worobey, M.; Leendertz, F. H.; Schnalke, T.; Wolff, T.; Lemey, P.; Calvignac-Spencer, S.
10.1101/2021.05.14.444134 — microbiology — Posted on 2021-05-14
2471 Two microbiota subtypes identified in Irritable Bowel Syndrome with distinct responses to the low-FODMAP diet
Vervier, K.; Moss, S.; Kumar, N.; Adoum, A.; Barne, M.; Browne, H. P.; Kaser, A.; Kiely, C. J.; Neville, A.; Powell, N.; Raine, T.; Stare, M. D.; Zhu, A.; De La Revilla Negro, J.; Lawley, T. D.; Parkes, M.
10.1101/2021.05.14.444142 — microbiology — Posted on 2021-05-14
2473 Elucidating the correlation between the number of TTTTGAT heptamer repeats and cholera toxin promoter activity in Vibrio cholerae O1 pandemic strains
Naha, A.; Withey, J. H.; Mukherjee, P.; Saha, R. N.; Samanta, P.; Ghosh, A.; Miyoshi, S.-i.; Dutta, S.; Mukhopadhyay, A. K.
10.1101/2021.05.14.444153 — microbiology — Posted on 2021-05-14
2475 Correction of amblyopia in cats and mice after the critical period
Fong, M.-f.; Duffy, K. R.; Leet, M. P.; Candler, C. T.; Bear, M. F.
10.1101/2021.05.03.442423 — neuroscience — Posted on 2021-05-14
2476 Atypical genomic cortical patterning in autism with poor early language outcome
Lombardo, M. V.; Eyler, L.; Pramparo, T.; Gazestani, V. H.; Hagler, D. J.; Chen, C.-H.; Dale, A. M.; Seidlitz, J.; Bethlehem, R. A. I.; Bertelsen, N.; Carter Barnes, C.; Lopez, L.; Campbell, K.; Lewis, N. E.; Pierce, K.; Courchesne, E.
10.1101/2020.08.18.253443 — neuroscience — Posted on 2021-05-14
2477 Circadian rhythm in cortical chloride homeostasis underpins variation in network excitability
Pracucci, E.; Graham, R.; Alberio, L. S.; Nardi, G.; Cozzolino, O.; Pillai, V.; Saieva, L.; Walsh, D.; Landi, S.; Zhang, J.; Trevelyan, A. J.; Ratto, G. M. M.
10.1101/2021.05.12.443725 — neuroscience — Posted on 2021-05-14
2479 Urinary glucocorticoids in harbour seal (Phoca vitulina) pups during rehabilitation
Wilson, S. C.; Villanueva, S.; Jones, K. A.; Dmitrieva, L.; Hayes, W.; Smyth, W.
10.1101/549386 — zoology — Posted on 2021-05-14
2480 Viral integration transforms chromatin to drive oncogenesis
Karimzadeh, M.; Arlidge, C.; Rostami, A.; Lupien, M.; Bratman, S. V.; Hoffman, M. M.
10.1101/2020.02.12.942755 — cancer biology — Posted on 2021-05-14
2481 Effective clustering for single cell sequencing cancer data
Ciccolella, S.; Patterson, M.; Bonizzoni, P.; Della Vedova, G.
10.1101/586545 — cancer biology — Posted on 2021-05-14
2485 Colicin E1 binds to TolC as an open hinge to penetrate the outer-membrane
Budiardjo, S. J.; Stevens, J. J.; Calkins, A. L.; Ikujuni, A. P.; Wimalasena, V. K.; Firlar, E.; Case, D.; Biteen, J. S.; Kaelber, J.; Slusky, J. S. G.
10.1101/692251 — biophysics — Posted on 2021-05-14
2488 The First High-Quality Reference Genome of Sika Deer Provides Insights for High-Tannin Adaptation
Xing, X.; Ai, C.; Wang, T.; LI, Y.; Liu, H.; Hu, P.; Wang, G.; Liu, H.; Wang, H.; Zhang, R.; Zheng, J.; Wang, X.; Wang, L.; Chang, Y.; Qian, Q.; Yu, J.; Tang, L.; Wu, S.; Shao, X.; Li, A.; Cui, P.; Zhan, W.; Zhao, S.; Wu, Z.; Shao, X.; Dong, Y.; Rong, M.; Tan, Y.; Cui, X.; Chang, S.; Song, X.; Yang, T.; Sun, L.; Ju, Y.; Zhao, P.; Fan, H.; Liu, Y.; Wang, X.; Yang, W.; Yang, M.; Wei, T.; Song, S.; Xu, J.; Yue, Z.; Liang, Q.; Li, C.; Ruan, J.; Yang, F.
10.1101/2021.05.13.443962 — genomics — Posted on 2021-05-14
2489 Games of risk and reward in carnivore communities
Ruprecht, J.; Eriksson, C. E.; Forrester, T. D.; Spitz, D. B.; Clark, D. A.; Wisdom, M. J.; Bianco, M.; Rowland, M. M.; Smith, J. B.; Johnson, B. K.; Levi, T.
10.1101/2021.01.27.428481 — ecology — Posted on 2021-05-14
2490 Cell patterning by secretion-induced plasma membrane flows
Gerganova, V.; Lamas, I.; Rutkowski, D. M.; Vjestica, A.; Gallo Castro, D.; Vincenzetti, V.; Vavylonis, D.; Martin, S. G.
10.1101/2020.12.18.423457 — cell biology — Posted on 2021-05-14
2491 Glucosidase inhibitors suppress SARS-CoV-2 in tissue culture and may potentiate
Reyes, H.; Du, Y.; Zhou, T.; Xie, X.; Shi, P.-Y.; Weiss, S. R.; Block, T.
10.1101/2021.05.14.444190 — microbiology — Posted on 2021-05-14
2492 Isolation and characterization of SARS-CoV-2 VOC, 20H/501Y.V2, from UAE travelers
Yadav, P.; Sarkale, P.; Razdan, A.; Gupta, N.; Nyayanit, D.; Sahay, R.; Potdar, V.; Patil, D.; Baradkar, S.; Kumar, A.; Aggarwal, N.; Shete, A.; Kaur, H.
10.1101/2021.05.14.443968 — microbiology — Posted on 2021-05-14
2493 A recombinant rotavirus harboring a spike protein with a heterologous peptide reveals a novel role of VP4 in viroplasm stability
Papa, G.; Vetter, J.; Seyffert, M.; Gunasekera, K.; De Lorenzo, G.; Wiesendanger, M.; Schraner, E. M.; Reymond, J.-L.; Fraefel, C.; Burrone, O. R.; Eichwald, C.
10.1101/2021.05.13.444118 — microbiology — Posted on 2021-05-14
2495 Suicidal thoughts, behaviors, and event-related potentials: A systematic review and meta-analysis
Gallyer, A. J.; Dougherty, S. P.; Burani, K.; Albanese, B. J.; Joiner, T. E.; Hajcak, G.
10.1101/2020.04.29.069005 — neuroscience — Posted on 2021-05-14
2496 Altered cerebellar response to somatosensory stimuli in the Cntnap2 mouse model of autism
Fernandez, M.; Sanchez-Leon, C. A.; Llorente, J.; Sierra-Arregui, T.; Knafo, S.; Marquez-Ruiz, J.; Penagarikano, O.
10.1101/2021.05.13.443762 — neuroscience — Posted on 2021-05-14
2498 Yin Yang 1 sets up the stage for cerebellar astrocyte maturation
Mockenhaupt, K.; Tyc, K. M.; McQuiston, A.; Hariprashad, A.; Biswas, D. D.; Gupta, A. S.; Olex, A.; Singh, S. K.; Waters, M. R.; Dupree, J. L.; Dozmorov, M. G.; Kordula, T.
10.1101/2021.05.14.444129 — neuroscience — Posted on 2021-05-14
2500 Ecdysteroids as natural doping substances in the blood of insectivorous bats
Hornok, S.; Berkecz, R.; Sos, E.; Sandor, A. D.; Körmöczi, T.; Solymosi, N.; Kontschan, J.; Hunyadi, A.
10.1101/2021.05.12.443761 — zoology — Posted on 2021-05-14
2501 Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells
Mendez-Mancilla, A.; Wessels, H.-H.; Legut, M.; Kadina, A.; Mabuchi, M.; Walker, J.; Robb, G. B.; Holden, K.; Sanjana, N. E.
10.1101/2021.05.12.443920 — bioengineering — Posted on 2021-05-14
2504 Diet effects on mouse sperm: a warning for recombination studies
de la Casa-Esperon, E.; San Martin Perez, E.; Belmonte Tebar, A.; Nam-Cha, S. H.; Soler Valls, A. J.; Singh, N. D.
10.1101/2021.05.12.443881 — genetics — Posted on 2021-05-14
2505 Vitrifying multiple embryos in different arrangements does not alter the cooling rate
Ostler, T.; Woolley, T. E.; Swann, K.; Thomson, A.; Palmer, G.; Priddle, H.; Kaouri, K.
10.1101/2021.05.12.443816 — developmental biology — Posted on 2021-05-14
2506 Mechanistic insights into dideoxygenation in gentamicin biosynthesis
Li, S.; Bury, P. d. S.; Huang, F.; Guo, J.; Sun, G.; Reva, A.; Huang, C.; Jian, X.; Li, Y.; Zhou, J.; Deng, Z.; Leeper, F. J.; Leadlay, P. F.; Dias, M. V. B.; Sun, Y.
10.1101/2021.05.12.443773 — microbiology — Posted on 2021-05-14
2509 ADP-ribose triggers neuronal ferroptosis via metabolic orchestrating
Yuan, L.; Ni, H.; Lei, H.; Wang, Y.; Wang, B.; Chen, B.; ZhuGe, Q.; Shen, Y.; Yin, Q.
10.1101/2021.05.12.443941 — neuroscience — Posted on 2021-05-14
2511 Calorie Restriction in combination with GABA: improved glycaemic control in type 2 diabetes mouse model
Rathwa, N.; Parmar, N.; Pramanik Palit, S.; Patel, R.; Shankar Bhaskaran, R.; Ramachandran, A. V.; Begum, R.
10.1101/2021.05.12.443226 — physiology — Posted on 2021-05-14
2513 Flexibility of a mammalian lipidome - insights from mouse lipidomics
Surma, M. A.; Gerl, M. J.; Herzog, R.; Helppi, J.; Simons, K.; Klose, C.
10.1101/2021.05.12.443735 — biochemistry — Posted on 2021-05-14
2515 A sex-specific evolutionary interaction between ADCY9 and CETP
Gamache, I.; Legault, M.-A.; Grenier, J.-C.; Sanchez, R.; Rheaume, E.; Asgari, S.; Barhdadi, A.; Zada, Y. F.; Trochet, H.; Luo, Y.; Lecca, L.; Murray, M.; Raychaudhuri, S.; Tardif, J.-C.; Dube, M.-P.; Hussin, J. G.
10.1101/2021.05.12.443794 — genetics — Posted on 2021-05-14
2518 A single short reprogramming early in life improves fitness and increase lifespan in old age
ALLE, Q.; LE-BORGNE, E.; BEN-SADOUN, P.; LEMEY, C.; BECHIR, N.; GABANOU, M.; ESTERMANN, F.; BERTRAND, C.; PESSEMESSE, L.; TOUPET, K.; VIALARET, J.; HIRTZ, C.; Noel, D.; JORGENSEN, C.; CASAS, F.; MILHAVET, O.; LEMAITRE, J.-M.
10.1101/2021.05.13.443979 — developmental biology — Posted on 2021-05-14
2519 Sperm cryopreservation impacts the early development of equine embryos by downregulating specific transcription factors
Ortiz-Rodriguez, J. M.; Martin-Cano, F. E.; Gaitskell-Phillips, G. L.; Alvarez Barrientos, A.; Rodriguez-Martinez, H.; Gil Anaya, C.; Ortega-Ferrusola, C.; Pena-Vega, F. J.
10.1101/2021.05.12.443855 — developmental biology — Posted on 2021-05-14
2520 D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes
Connolly, J. P.; Turner, N. C.; Hallam, J. C.; Rimbi, P. T.; Flett, T.; McCormack, M. J.; Roe, A. J.; O'Boyle, N.
10.1101/2021.05.12.443952 — molecular biology — Posted on 2021-05-14
2521 Chromatin state barriers enforce an irreversible mammalian cell fate decision
Blanco, M. A.; Sykes, D.; Gu, L.; Wu, M.; Petroni, R.; Karnik, R.; Wawer, M.; Rico, J.; Li, H.; Jacobus, W.; Jambhekar, A.; Cheloufi, S.; Meissner, A.; Hochedlinger, K.; Scadden, D.; Shi, Y.
10.1101/2021.05.12.443709 — molecular biology — Posted on 2021-05-14
2522 Passive sampling of environmental DNA in aquatic environments using 3D-printed hydroxyapatite samplers
Verdier, H.; Konecny-Dupre, L.; Marquette, C.; Reveron, H.; Tadier, S.; Gremillard, L.; Barthes, A.; Datry, T.; Bouchez, A.; Lefebure, T.
10.1101/2021.05.12.443744 — molecular biology — Posted on 2021-05-14
2523 Anatomy promotes neutral coexistence of strains in the human skin microbiome
Conwill, A.; Kuan, A. C.; Damerla, R.; Poret, A. J.; Baker, J. S.; Tripp, A. D.; Alm, E. J.; Lieberman, T. D.
10.1101/2021.05.12.443817 — microbiology — Posted on 2021-05-14
2524 Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
Brugger, M.; Demoulins, T.; Barut, G. T.; Zumkehr, B.; Oliveira Esteves, B.; Mehinagic, K.; Haas, Q.; Schogler, A.; Rameix-Welti, M.-A.; Eleouet, J.-F.; Moehrlen, U.; Marti, T.; Schmid, R.; Summerfield, A.; Posthaus, H.; Ruggli, N.; Hall, S.; Alves, M. P.
10.1101/2021.05.12.443770 — microbiology — Posted on 2021-05-14
2525 Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
de Vries, L. E.; Jansen, P. A.; Barcelo, C.; Munro, J.; Verhoef, J. M.; Pasaje, C. F. A.; Rubiano, K.; Striepen, J.; Bolscher, J. M.; Henderson, R.; Huijs, T.; Koolen, K. M.; Tumwebaze, P. K.; Yeo, T.; Aguiar, A. C.; Angulo-Barturen, I.; Churchyard, A.; Baum, J.; Fernandez, B. C.; Gamo, F.-J.; Guido, R. V.; Jimenez-Diaz, M. B.; Pereira, D. B.; Rochford, R.; Sanz, L. M.; Trevitt, G.; Wittlin, S.; Cooper, R. A.; Rosenthal, P. J.; Sauerwein, R. W.; Schalkwijk, J.; Hermkens, P. H.; Bonnert, R.; Campo, B.; Fidock, D. A.; Llinas, M.; Niles, J. C.; Kooij, T. W.; Dechering, K. J.
10.1101/2021.05.12.443866 — microbiology — Posted on 2021-05-14
2526 Temporal dynamics of microbial transcription in wetted hyperarid desert soils
Leon-Sobrino, C.; Ramond, J.-B.; Coclet, C.; Kapitango, R.-M.; Maggs-Kölling, G.; Cowan, D. A.
10.1101/2021.05.12.443739 — microbiology — Posted on 2021-05-14
2528 Anti-microbiota vaccines modulate the tick microbiome in a taxon-specific manner
Mateos-Hernandez, L.; Obregon, D.; Wu-Chuang, A.; Maye, J.; Borneres, J.; Versille, N.; de la Fuente, J.; Diaz, S.; Bermudez-Humaran, L.; Torres-Maravilla, E.; Estrada-Pena, A.; Hodzic, A.; Simo, L.; Cabezas-Cruz, A.
10.1101/2021.05.12.443756 — immunology — Posted on 2021-05-14
2529 Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis growth in alveolar epithelial cells and bacterial translocation into the cytosol
Olmo-Fontanez, A. M.; Scordo, J. M.; Garcia-Vilanova, A.; Maselli, D. J.; Peters, J.; Restrepo, B. I.; Clemens, D. L.; Turner, J.; Schlesinger, L. S.; Torrelles, J. B.
10.1101/2021.05.12.443884 — immunology — Posted on 2021-05-14
2531 Mapping Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells
Shetty, A.; Bhosale, S. D.; Tripathi, S. K.; Buchacher, T.; Biradar, R.; Rasool, O.; Moulder, R.; Galande, S.; Lahesmaa, R.
10.1101/2021.05.12.443731 — immunology — Posted on 2021-05-14
2532 Diurnal variation in neuronal chloride levels and seizure susceptibility, in neocortex, reflecting changes in activity of chloride-cation-cotransporters
Pracucci, E.; Graham, R.; Alberio, L. S.; Nardi, G.; Cozzolino, O.; Pillai, V.; Saieva, L.; Walsh, D.; Landi, S.; Zhang, J.; Trevelyan, A. J.; Ratto, G. M. M.
10.1101/2021.05.12.443725 — neuroscience — Posted on 2021-05-14
2538 Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells
Gastfriend, B. D.; Nishihara, H.; Canfield, S. G.; Foreman, K. L.; Engelhardt, B.; Palecek, S. P.; Shusta, E. V.
10.1101/2021.05.12.443828 — neuroscience — Posted on 2021-05-14
2539 Wiring logic of the early rodent olfactory system revealed by high-throughput sequencing of single neuron projections
Chen, Y.; Chen, X.; Baserdem, B.; Zhan, H.; Li, Y.; Davis, M. B.; Kebschull, J. M.; Zador, A. M.; Koulakov, A. A.; Albeanu, D. F.
10.1101/2021.05.12.443929 — neuroscience — Posted on 2021-05-14
2541 Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols
Bean, B. D.; Mulvihill, C.; Garge, R. K.; Boutz, D. R.; Rousseau, O.; Floyd, B. M.; Cheney, W.; Gardner, E. C.; Ellington, A. D.; Marcotte, E. M.; Gollihar, J. D.; Whiteway, M.; Martin, V. J.
10.1101/2021.05.12.443385 — synthetic biology — Posted on 2021-05-14
2543 Sortilin exhibits tumor suppressor-like activity by limiting EGFR transducing function
Lapeyronnie, E.; Granet, C.; Tricard, J.; Gallet, P.; Yassine, M.; Chermat, A.; Jauberteau, M. O.; Melloni, B.; Vincent, F.; Naves, T.; Lalloue, F.
10.1101/2021.05.12.443742 — cancer biology — Posted on 2021-05-14
2545 Frequency Comb Optoacoustic Tomography
Stylogiannis, A.; Prade, L.; Glasl, S.; Mustafa, Q.; Zakian, C.; Ntziachristos, V.
10.1101/2021.05.12.443808 — biophysics — Posted on 2021-05-14
2549 Residue-specific insights into (2x)72 kDa tryptophan synthase obtained from fast-MAS 1H-detected solid-state NMR
Klein, A.; Rovó, P.; Sakhrani, V. V.; Wang, Y.; Holmes, J.; Liu, V.; Skowronek, P.; Kukuk, L.; Vasa, S. K.; Güntert, P.; Mueller, L. J.; Linser, R.
10.1101/2021.05.12.443859 — biochemistry — Posted on 2021-05-14
2550 Saturation variant interpretation using CRISPR prime editing
Erwood, S.; Bily, T. M.; Lequyer, J.; Yan, J.; Gulati, N.; Brewer, R. A.; Zhou, L.; Pelletier, L.; Ivakine, E. A.; Cohn, R. D.
10.1101/2021.05.11.443710 — genetics — Posted on 2021-05-14
2556 Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species
Schafer, A.; Gralinski, L. E.; Leist, S. R.; Winkler, E. S.; Hampton, B. K.; Mooney, M. A.; Jensen, K. L.; Graham, R. L.; Agnihothram, S.; Jeng, S.; Chamberlin, S.; Bell, T. A.; Scobey, D. T.; VanBlargan, L. A.; Thackray, L. B.; Hock, P.; Miller, D. R.; Shaw, G. D.; Pardo Manuel de Villena, F.; McWeeney, S. K.; Montgomery, S. A.; Diamond, M. S.; Heise, M. T.; Menachery, V. D.; Ferris, M. T.; Baric, R. S.
10.1101/2021.05.14.444205 — microbiology — Posted on 2021-05-14
2557 Siglec-1 on dendritic cells mediates SARS-CoV-2 trans-infection of target cells while on macrophages triggers proinflammatory responses
Perez-Zsolt, D.; Munoz Basagoiti, J.; Rodo, J.; Elousa, M.; Raich Regue, D.; Risco, C.; Sachse, M.; Pino, M.; Gumber, S.; Paiardini, M.; Chojnacki, J.; Erkizia, I.; Muniz, X.; Ballana, E.; Riveira Munoz, E.; Noguera-Julian, M.; Paredes, R.; Trinite, B.; Tarres Freixas, F.; Blanco, I.; Guallar, V.; Carrillo, J.; Blanco, J.; Telenti, A.; Heyn, H.; Segales, J.; Clotet, B.; Martinez-Picado, J.; Vergara-Alert, J.; Izquierdo-Useros, N.
10.1101/2021.05.11.443572 — microbiology — Posted on 2021-05-14
2562 Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy
Strong, L. M.; Chang, C.; Boecker, A.; Flower, T. G.; Buffalo, C. Z.; Ren, X.; Stavoe, A. K.; Holzbaur, E. L. F.; Hurley, J. H.
10.1101/2021.05.14.444175 — cell biology — Posted on 2021-05-14
2563 The environmental stress response regulates ribosome content in cell cycle-arrested S. cerevisiae
Terhorst, A.; Sandikci, A.; Neurohr, G. E.; Whittaker, C. A.; Szoradi, T.; Holt, L. J.; Amon, A.
10.1101/2021.05.14.444167 — cell biology — Posted on 2021-05-14
2564 Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes
Yang, C.-H.; Ann-Onda, D.; Lin, X.; Fynch, S.; Nadarajah, S.; Pappas, E.; Liu, X.; Scott, J.; Oakhill, J. S.; Galic, S.; Shi, Y.; Moreno-Asso, A.; Smith, C.; Loudovaris, T.; Levinger, I.; Eizirik, D. L.; Laybutt, R.; Herzog, H.; Thomas, H.; Loh, K.
10.1101/2021.05.14.444149 — cell biology — Posted on 2021-05-14
2566 Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry
Hayashi-Takanaka, Y.; Hayashi, Y.; Hirano, Y.; Miyawaki-Kuwakado, A.; Ohkawa, Y.; Obuse, C.; Kimura, H.; Haraguchi, T.; Hiraoka, Y.
10.1101/2021.05.14.443718 — cell biology — Posted on 2021-05-14
2567 Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Dannenmaier, S.; Desroches Altamirano, C.; Schueler, L.; Zhang, Y.; Hummel, J.; Oeljeklaus, S.; Koch, H.-G.; Rospert, S.; Alberti, S.; Warscheid, B.
10.1101/2021.05.12.443772 — cell biology — Posted on 2021-05-14
2568 WASP integrates substrate topology and cell polarity to guide neutrophil migration
Brunetti, R. M.; Kockelkoren, G.; Raghavan, P.; Bell, G. R. R.; Britain, D.; Puri, N.; Collins, S. R.; Leonetti, M. D.; Stamou, D.; Weiner, O. D.
10.1101/2021.05.12.443722 — cell biology — Posted on 2021-05-14
2570 Nitric oxide synthase neurons in the preoptic hypothalamus are sleep-active and contribute to regulating NREM and REM sleep and lowering body temperature.
Harding, E. C.; Ba, W.; Zahir, R.; Yu, X.; Yustos, R.; Hsieh, B.; Lignos, L.; Vyssotski, A. L.; Constandinou, T.; Franks, N. P.; Wisden, W.
10.1101/2021.05.14.444161 — neuroscience — Posted on 2021-05-14
2572 Piezo1 activation using Yoda1 inhibits macropinocytosis and proliferation of cancer cells
Kuriyama, M.; Hirose, H.; Masuda, T.; Shudou, M.; Arafiles, J. V. V.; Imanishi, M.; Maekawa, M.; Hara, Y.; Futaki, S.
10.1101/2021.05.14.444123 — cell biology — Posted on 2021-05-14
2574 Beyond resting state neuronal avalanches in the somatosensory barrel cortex
Mariani, B.; Nicoletti, G.; Bisio, M.; Maschietto, M.; Oboe, R.; Suweis, S.; Vassanelli, S.
10.1101/2021.05.13.444047 — neuroscience — Posted on 2021-05-14
2576 RNA-seq and differential expression analysis of the duck transcriptome: The effect of short-term cage-rearing
Chen, B.; Fang, W.; Li, Y.; Xiong, T.; Zhou, M.; Wan, L.; Liu, Q.; Zhang, W.; Hu, X.; Mao, H.; Liu, S.
10.1101/2021.05.13.444049 — genetics — Posted on 2021-05-14
2579 Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression
Bruinstroop, E.; Zhou, J.; Tripathi, M.; Yau, W.; Boelen, A.; Singh, B. K.; Yen, P. M.
10.1101/2021.05.13.443791 — molecular biology — Posted on 2021-05-14
2582 Localization and RNAi-driven inhibition of a Brugia malayi encoded Interleukin-5 Receptor Binding protein
Mejia, R.; Bennuru, S.; Oksov, Y.; Lustigman, S.; Munirathinam, G.; Kalyanasundaram, R.; Nutman, T. B.
10.1101/2021.05.13.443627 — pathology — Posted on 2021-05-14
2591 The Origin of Bladder Cancer from Mucosal Field Effects
Bondaruk, J.; Jaksik, R.; Wang, Z.; Cogdell, D.; Lee, S.; Chen, Y.; Dinh, K. N.; Majewski, T.; Zhang, L.; Cao, S.; Yao, H.; Weinstein, J. N.; Navai, N.; Dinney, C.; Gao, J.; Theodorescu, D.; Logothetis, C.; Guo, C. C.; Wang, W.; McConkey, D. J.; Wei, P.; Kimmel, M.; Czerniak, B.
10.1101/2021.05.12.443785 — genomics — Posted on 2021-05-14
2593 Homogeneous environmental selection overturns distance-decay relationship of soil prokaryotic community
Zhang, B.; Xue, K.; Zhou, S.; Wang, K.; Liu, W.; Xu, C.; Cui, L.; Li, L.; Ran, Q.; Hu, R.; Hao, Y.; Cui, X.; Wang, Y.
10.1101/2021.05.13.443991 — ecology — Posted on 2021-05-14
2596 Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 binding
Alenquer, M.; Ferreira, F.; Lousa, D.; Valerio, M.; Medina-Lopes, M.; Bergman, M.-L.; Goncalves, J.; Demengeot, J.; Leite, R. B.; Lilue, J.; Ning, Z.; Penha-Goncalves, C.; Soares, H.; Soares, C.; Amorim, M. J.
10.1101/2021.04.22.441007 — immunology — Posted on 2021-05-14
2598 Temporal Dynamics of Neural Processing of Facial Expressions and Emotions
Nara, S.; Rathee, D.; Molinaro, N.; Bois, N. D.; Bhushan, B.; Prasad, G.
10.1101/2021.05.12.443280 — neuroscience — Posted on 2021-05-14
2601 nGauge: Integrated and extensible neuron morphology analysis in Python
Walker, L. A.; Williams, J. S.; Li, Y.; Roossien, D. H.; Michki, N. S.; Cai, D.
10.1101/2021.05.13.443832 — neuroscience — Posted on 2021-05-14
2602 A Genome-Scale TF-DNA Interaction Network of Transcriptional Regulation of Arabidopsis Primary and Specialized Metabolism
Tang, M.; Li, B.; Zhou, X.; Bolt, T.; Li, J. J.; Cruz, N.; Gaudinier, A.; Ngo, R.; Clark-Wiest, C.; Kliebenstein, D.; Brady, S.
10.1101/2021.05.13.443927 — systems biology — Posted on 2021-05-14
2604 Deep protein representations enable recombinant protein expression prediction
Martiny, H.-M.; Armenteros, J. J. A.; Johansen, A. R.; Salomon, J.; Nielsen, H.
10.1101/2021.05.13.443426 — bioinformatics — Posted on 2021-05-14
2605 An Explainable Deep Learning Approach for Multimodal Electrophysiology Classification
Ellis, C. A.; Carbajal, D. A.; Zhang, R.; Miller, R. L.; Calhoun, V. D.; Wang, M. D.
10.1101/2021.05.12.443594 — bioinformatics — Posted on 2021-05-14
2611 Purine auxotrophic starvation evokes quiescence like phenotype in the budding yeast
Kokina, A.; Ozolina, Z.; Pleiko, K.; Svirksts, K.; Tanilas, K.; Vamza, I.; Liepins, J.
10.1101/2021.03.15.435510 — cell biology — Posted on 2021-05-14
2612 Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
Weber, M.; Eibauer, M.; Sivagurunathan, S.; Magin, T.; Goldman, R. D.; Medalia, O.
10.1101/2021.05.12.442145 — cell biology — Posted on 2021-05-14
2615 Powering electronic implants by high frequency volume conduction: in human validation
Minguillon, J.; Tudela-Pi, M.; Becerra-Fajardo, L.; Perera-Bel, E.; del-Ama, A. J.; Gil-Agudo, A.; Megia-Garcia, A.; Garcia-Moreno, A.; Ivorra, A.
10.1101/2021.03.15.435404 — bioengineering — Posted on 2021-05-14
2616 Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment
Ross, J.; McIver, Z.; Lambert, T.; Piergentili, C.; Gallagher, K. J.; Bird, J. E.; Cruickshank, F. L.; Zarazua-Arvizu, E.; Horsfall, L. E.; Waldron, K. J.; Wilson, M. D.; Mackay, C. L.; Basle, A.; Clarke, D. J.; Marles-Wright, J.
10.1101/2021.04.15.439977 — biochemistry — Posted on 2021-05-14
2617 HASTER is a transcriptional stabilizer of HNF1A
Beucher, A.; Miguel-Escalada, I.; Balboa Alonso, D.; De Vas, M. G.; Maestro, M. A.; Garcia-Hurtado, J.; Bernal, A.; Heyn, H.; Gonzalez Franco, R.; Vargiu, P.; Ortega, S.; Ravassard, P.; Ferrer, J.
10.1101/2021.05.12.443907 — genomics — Posted on 2021-05-14
2618 Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations
Langmüller, A. M.; Champer, J.; Lapinska, S.; Xie, L.; Metzloff, M.; Liu, J.; Xu, Y.; Clark, A. G.; Messer, P. W.
10.1101/2021.05.13.444039 — evolutionary biology — Posted on 2021-05-14
2622 A chemically-defined growth medium to support Lactobacillus-Acetobacter community analysis
Aumiller, K.; Stevens, E.; Scheffler, R.; Guvener, Z. T.; Tung, E.; Grimaldo, A. B.; Carlson, H. K.; Deutschbauer, A. M.; Taga, M. E.; Marco, M. L.; Ludington, W. B.
10.1101/2021.05.12.443930 — microbiology — Posted on 2021-05-14
2623 STING mediates immune responses in a unicellular choanoflagellate
Woznica, A.; Kumar, A.; Sturge, C. R.; Xing, C.; King, N.; Pfeiffer, J. K.
10.1101/2021.05.13.443778 — microbiology — Posted on 2021-05-14
2625 Visual speech differentially modulates beta, theta, and high gamma bands in auditory cortex
Ganesan, K.; Plass, J.; Beltz, A. M.; Liu, Z.; Grabowecky, M.; Suzuki, S.; Stacey, W. C.; Wasade, V. S.; Towle, V. L.; Tao, J. X.; Wu, S.; Issa, N. P.; Brang, D.
10.1101/2020.09.07.284455 — neuroscience — Posted on 2021-05-14
2626 Magnetoencephalographic Signatures of Conscious Processing Before Birth
Moser, J.; Schleger, F.; Weiss, M.; Sippel, K.; Semeia, L.; Preissl, H.
10.1101/2020.10.27.357129 — neuroscience — Posted on 2021-05-14
2627 Information flow, cell types and stereotypy in a full olfactory connectome
Schlegel, P.; Bates, A. S.; Stürner, T.; Jagannathan, S.; Drummond, N.; Hsu, J.; Serratosa Capdevila, L.; Javier, A.; Marin, E. C.; Barth-Maron, A.; Tamimi, I. F. M.; Li, F.; Rubin, G. M.; Plaza, S. M.; Costa, M.; Jefferis, G. S. X. E.
10.1101/2020.12.15.401257 — neuroscience — Posted on 2021-05-14
2632 Relative time constraints improve molecular dating
Szollosi, G. J.; Hoehna, S.; Williams, T. A.; Schrempf, D.; Daubin, V.; Boussau, B.
10.1101/2020.10.17.343889 — evolutionary biology — Posted on 2021-05-14
2634 Improvements in the Sequencing and Assembly of Plant Genomes
Sharma, P.; Aldossary, O.; Alsubaie, B.; Al-Mssallem, I.; Nath, O.; Mitter, N.; Margarido, G.; Topp, B.; Murigneux, V.; Masouleh, A.; Furtado, A.; Henry, R. J.
10.1101/2021.01.22.427724 — genomics — Posted on 2021-05-14
2636 Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude
Ju, J.; Lee, H. N.; Ning, L.; Ryu, H.; Zhou, X. X.; Chun, H.; Lee, Y. W.; Lee-Richerson, A. I.; Jeong, C.; Lin, M.; Seong, J.
10.1101/2021.02.05.430013 — bioengineering — Posted on 2021-05-14
2641 Truncating Tau Reveals Different Pathophysiological Actions of Oligomers in Single Neurons
Hill, E.; Karikari, T. K.; Lantero-Rodriguez, J.; Zetterberg, H.; Blennow, K.; Richardson, M. J.; Wall, M. J.
10.1101/2021.05.13.443904 — neuroscience — Posted on 2021-05-13
2642 Variable brain wiring through scalable and relative synapse formation in Drosophila
Kiral, F. R.; Dutta, S. B.; Linneweber, G. A.; Poppa, C.; von Kleist, M.; Hassan, B. A.; Hiesinger, P. R.
10.1101/2021.05.12.443860 — neuroscience — Posted on 2021-05-13
2647 Sex differences in microRNA expression in first and third trimester human placenta
Flowers, A. E.; Gonzalez, T. L.; Joshi, N. V.; Eisman, L. E.; Clark, E. L.; Buttle, R. A.; Sauro, E.; DiPentino, R.; Lin, Y.; Wu, D.; Wang, Y.; Santiskulvong, C.; Tang, J.; Lee, B.; Sun, T.; Chan, J. L.; Wang, E. T.; Jefferies, C.; Lawrenson, K.; Zhu, Y.; Afshar, Y.; Tseng, H.-R.; Williams, J.; Pisarska, M. D.
10.1101/2021.05.13.444056 — developmental biology — Posted on 2021-05-13
2649 Microgravity effect on murine T cells exposed to suborbital flight aboard Blue Origins New Shepard vehicle
Llanos, P. J.; Andrijauskaite, K.; Duraisamy, V. V.; Gangadharan, S.; Morris, J.; Wargovich, M.
10.1101/2021.05.13.443970 — cell biology — Posted on 2021-05-13
2650 Microtubule inhibitors enhance DNA transfection efficiency through autophagy receptor p62/SQSTM1
Tsuchiya, M.; Ogawa, H.; Watanabe, K.; Koujin, T.; Mori, C.; Nunomura, K.; Lin, B.; Tani, A.; Hiraoka, Y.; Haraguchi, T.
10.1101/2021.05.13.443985 — cell biology — Posted on 2021-05-13
2652 Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1
Harrison, G. F.; Leaton, L. A.; Harrison, E. A.; Viken, M. K.; Shortt, J.; Gignoux, C. R.; Lie, B. A.; Vukcevic, D.; Leslie, S.; Norman, P. J.
10.1101/2021.05.13.443975 — immunology — Posted on 2021-05-13
2653 Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota
Gutzeit, C.; Grasset, E. K.; Matthews, D. B.; Maglione, P. J.; Magri, G.; Britton, G. J.; Tomalin, L.; Pybus, M.; Tejedor Vaquero, S.; Veeramreddy, P. K.; Tacho-Pinot, R.; Martin Nalda, A.; Garcia Prat, M.; Martinez Gallo, M.; Dieli-Crimi, R.; Clemente, J. C.; Mehandru, S.; Suarez-Farina, M.; Faith, J. J.; Cunningham-Rundles, C.; Cerutti, A.
10.1101/2021.04.29.439534 — immunology — Posted on 2021-05-13
2659 Root specific plasticity induced by paclobutrazol confers improved deficit irrigation tolerance and agronomic performance in maize
Urfan, M.; Hakla, H. R.; Sharma, S.; Sharma, M.; Khajuria, M.; Satbhai, S. B.; Vyas, D.; Bhougal, S.; Yadav, N. S.; Pal, S.
10.1101/2020.05.12.087940 — plant biology — Posted on 2021-05-13
2661 Genetic Analysis of Human RNA Binding Motif Protein 48 (RBM48) Reveals an Essential Role in U12-Type Intron Splicing
Siebert, A. E.; Corll, J.; Gronevelt, J. P.; Levine, L.; Hobbs, L. M.; Kenney, C.; Davenport, R.; Settles, A. M.; Barbazuk, W. B.; Westrick, R. J.; Madlambayan, G. J.; Lal, S.
10.1101/2020.07.18.209528 — genetics — Posted on 2021-05-13
2662 Emergent RNA-RNA interactions can promote stability in a nascent phototrophic endosymbiosis
Jenkins, B. H.; Maguire, F.; Leonard, G.; Eaton, J. D.; West, S.; Housden, B. E.; Milner, D. S.; Richards, T. A.
10.1101/2021.04.11.439338 — evolutionary biology — Posted on 2021-05-13
2663 The recent evolutionary rescue of a staple crop depended on over half a century of global germplasm exchange
Muleta, K. T.; Felderhoff, T.; Winans, N.; Walstead, R.; Charles, J. R.; Armstrong, J. S.; Mamidi, S.; Plott, C.; Vogel, J. P.; Lemaux, P. G.; Mockler, T. C.; Grimwood, J.; Schmutz, J.; Pressoir, G.; Morris, G. P.
10.1101/2021.05.11.443651 — evolutionary biology — Posted on 2021-05-13
2664 Multifocal imaging for precise, label-free tracking of fast biological processes in 3D
Hansen, J. N.; Gong, A.; Wachten, D.; Pascal, R.; Turpin, A.; Jikeli, J. F.; Kaupp, U. B.; Alvarez, L.
10.1101/2020.05.16.099390 — cell biology — Posted on 2021-05-13
2665 APOBEC2 is a Transcriptional Repressor 1 required for proper Myoblast Differentiation
Lorenzo, J. P.; Molla, L.; Ibarra, I. L.; Ruf, S.; Ridani, J.; Subramani, P. G.; Boulais, J.; Harjanto, D.; Vonica, A.; Di Noia, J. M.; Dieterich, C.; Zaugg, J. B.; Papavasiliou, F. N.
10.1101/2020.07.29.223594 — molecular biology — Posted on 2021-05-13
2667 A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants
Diard, M.; Bakkeren, E.; Hoces, D.; Lentsch, V.; Arnoldini, M.; Boehi, F.; Schumann-Moor, K.; Adamcik, J.; Piccoli, L.; Lanzavecchia, A.; Stadtmueller, B.; Donohue, N.; Vanderwoude, M.; Viollier, P.; Falquet, L.; Hockenberry, A.; Wuethrich, D.; Bonfiglio, F.; Loverdo, C.; Egli, A.; Zandomeneghi, G.; Mezzenga, R.; Holst, O.; Meier, B.; Hardt, W.-D.; Slack, E.
10.1101/824821 — immunology — Posted on 2021-05-13
2669 Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice
Bennett, C.; Green, J.; Ciancio, M.; Goral, J.; Pitstick, L.; Pytynia, M.; Meyer, A.; Kwatra, N.; Jadavji, N. M.
10.1101/2020.12.13.422535 — neuroscience — Posted on 2021-05-13
2672 Estimated regional white matter hyperintensity burden, resting state functional connectivity, and cognitive functions in older adults
Jaywant, A.; Dunlop, K.; Victoria, L. W.; Oberlin, L.; Lynch, C.; Respino, M.; Kuceyeski, A.; Scult, M.; Hoptman, M.; Liston, C.; O'Dell, M. W.; Alexopoulos, G. S.; Perlis, R. H.; Gunning, F. M.
10.1101/2020.04.14.039065 — neuroscience — Posted on 2021-05-13
2673 Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni
Iida, A.; Sano, K.; Inokuchi, M.; Nomura, J.; Suzuki, T.; Kuriki, M.; Sogabe, M.; Susaki, D.; Tonosaki, K.; Kinoshita, T.; Hondo, E.
10.1101/2021.02.01.429082 — zoology — Posted on 2021-05-13
2677 Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson's Disease and Multiple System Atrophy
Pande, R.; Huang, Y.; Teeple, E.; Joshi, P.; Flores-Morales, A.; Latta- Mahieu, M.; Sardi, S. P.; Cedazo-Minguez, A.; Klinger, K. W.; Madden, S. L.; Rajpal, D.; Kumar, D.
10.1101/2021.05.06.442950 — genomics — Posted on 2021-05-13
2681 IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis
Fassett, M. S.; Braz, J. M.; Castellanos, C. A.; Schroeder, A. W.; Sadeghi, M.; Mar, D. J.; Zhou, C. J.; Shin, J.-S.; Basbaum, A. I.; Ansel, K. M.
10.1101/2021.05.12.443916 — immunology — Posted on 2021-05-13
2682 Mice lacking the cAMP effector protein POPDC1 show enhanced hippocampal synaptic plasticity
Shetty, M. S.; Ris, L.; Schindler, R. F. R.; Mizuno, K.; Fedele, L.; Giese, K. P.; Brand, T.; Abel, T.
10.1101/2021.05.12.443909 — neuroscience — Posted on 2021-05-13
2686 Dynamically Linking Influenza Virus Infection Kinetics, Lung Injury, Inflammation, and Disease Severity
Myers, M. A.; Smith, A. P.; Lane, L. C.; Moquin, D. J.; Aogo, R.; Woolard, S.; Thomas, P.; Vogel, P.; Smith, A. M.
10.1101/555276 — systems biology — Posted on 2021-05-13
2687 Neural cell injury pathology due to high-rate mechanical loading
Estrada, J. B.; Cramer, H. C.; Scimone, M. T.; Buyukozturk, S.; Franck, C.
10.1101/2021.05.12.443823 — biophysics — Posted on 2021-05-13
2689 Universal amyloidogenicity of patient-derivedimmunoglobulin light chains
Sternke-Hoffmann, R.; Pauly, T.; Norrild, R. K.; Hansen, J.; Dupre, M.; Tucholski, F.; Duchateau, M.; Rey, M.; Metzger, S.; Boquoi, A.; Platten, F.; Egelhaaf, S. U.; Chamot-Rooke, J.; Fenk, R.; Nagel-Steger, L.; Haas, R.; Buell, A. K.
10.1101/2021.05.12.443858 — biophysics — Posted on 2021-05-13
2691 A catalog of transcription start sites across 115 human tissue and cell types
Moore, J. E.; Zhang, X.-O.; Elhajjajy, S. I.; Fan, K.; Reese, F.; Mortazavi, A.; Weng, Z.
10.1101/2021.05.12.443890 — genomics — Posted on 2021-05-13
2693 Complex introgression among three diverged largemouth bass lineages
Silliman, K.; Zhao, H.; Justice, M.; Thongda, W.; Bowen, B.; Peatman, E.
10.1101/2021.05.12.443886 — evolutionary biology — Posted on 2021-05-13
2695 A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue
Kimble, A. L.; Silva, J.; Murphy, M.; Hensel, J. A.; Nicholas, S.-A. E.; Jellison, E. R.; Reese, B.; Murphy, P. A.
10.1101/2021.05.12.443932 — cell biology — Posted on 2021-05-13
2699 SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
Tapia del Fierro, A.; den Hamer, B.; Jansz, N.; Chen, K.; Beck, T.; Vanyai, H.; Benetti, N.; Gurzau, A. D.; Daxinger, L.; Xue, S.; Nguyen Ly, T. T.; Wanigasuriya, I.; Breslin, K.; Oey, H.; Krom, Y.; van der Hoorn, D.; Bouwman, L. F.; Ritchie, M. E.; Reversade, B.; Prin, F.; Mohun, T.; van der Maarel, S. M.; McGlinn, E.; Murphy, J. M.; Keniry, A.; de Greef, J. C.; Blewitt, M. E.
10.1101/2021.05.12.443934 — molecular biology — Posted on 2021-05-13
2700 Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms
Reuter, C.; Imdahl, F.; Hauf, L.; Vafadarnejad, E.; Fey, P.; Finger, T.; Walles, H.; Saliba, A.-E.; Groeber-Becker, F.; Engstler, M.
10.1101/2021.05.13.443986 — microbiology — Posted on 2021-05-13
2701 Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System
Tachiyama, S.; Skaar, R.; Chang, Y.; Carroll, B.; Muthuramalingam, M.; Whittier, S. K.; Barta, M. L.; Picking, W. L.; Liu, J.; Picking, W. D.
10.1101/2021.05.13.444006 — microbiology — Posted on 2021-05-13
2706 Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection
Cervantes-Barragan, L.; Vanderheiden, A.; Royer, C. J.; Davis-Gardner, M. E.; Ralfs, P.; Chirkova, T.; Anderson, L. J.; Grakoui, A.; Suthar, M. S.
10.1101/2021.05.12.443948 — immunology — Posted on 2021-05-13
2709 Brace root phenotypes predict root lodging susceptibility and the contribution to anchorage in maize
Hostetler, A. N.; Erndwein, L.; Reneau, J. W.; Cantera, W.; Stager, A.; Tanner, H. G.; Cook, D.; Sparks, E. E.
10.1101/2021.05.12.443923 — plant biology — Posted on 2021-05-13
2710 Structural and cellular transcriptome foundations of human brain disease
Zeighami, Y.; Bakken, T. E.; Nickl-Jockschat, T.; Miller, J. A.; Evans, A. C.; Lein, E.; Hawrylycz, M.
10.1101/2021.05.12.443911 — neuroscience — Posted on 2021-05-13
2711 Spatiotemporal 3D image registration for mesoscale studies of brain development.
Shuvaev, S.; Lazutkin, A.; Kiryanov, R.; Anokhin, K.; Enikolopov, G.; Koulakov, A. A.
10.1101/2021.05.12.443839 — neuroscience — Posted on 2021-05-13
2713 Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics
Vahabikashi, A.; Sivagurunathan, S.; Nicdao, F. A. S.; Han, Y. L.; Park, C. Y.; Tran, J. R.; Gundersen, G. G.; Reddy, K.; Luxton, G. G.; Guo, M.; Fredberg, J. J.; Zheng, Y.; Adam, S. A.; Goldman, R. D.
10.1101/2021.05.12.443683 — biophysics — Posted on 2021-05-13
2714 Total Biosynthesis of Triacsin Featuring an N-hydroxytriazene Pharmacophore
Del Rio Flores, A.; Twigg, F. F.; Du, Y.; Cai, W.; Aguirre, D. Q.; Sato, M.; Dror, M. J.; Narayanamoorthy, M.; Geng, J.; Zill, N. A.; Zhang, W.
10.1101/2021.05.12.443849 — biochemistry — Posted on 2021-05-13
2718 Dual functions of ZmGI1 in the photoperiodic flowering pathway and salt stress responses in maize
Wu, F.; Liu, L.; Kang, Y.; Li, J.; Ma, Z.; Yahaya, B. S.; Xu, J.; Wang, Q.; Feng, X.; Li, J.; Hu, E.; Liu, Y.; Lu, Y.
10.1101/2021.05.12.443837 — developmental biology — Posted on 2021-05-13
2722 cAMP controls a trafficking mechanism that directs the neuron specificity and subcellular placement of electrical synapses
Palumbos, S.; Skelton, R.; McWhirter, R.; Mitchell, A.; Swann, I.; Heifner, S.; Von Stetina, S.; Miller, D. M.
10.1101/2021.05.12.443836 — neuroscience — Posted on 2021-05-13
2724 ABA homeostasis and long-distance translocation is redundantly regulated by ABCG ABA importers
Zhang, Y.; Vasuki, H.; Liu, J.; Bar, H.; Lazary, S.; Egbaria, A.; Ripper, D.; Charrier, L.; Mussa, Z.; Wulff, N.; Nour-Eldin, H. H.; Aharoni, A.; Ragni, L.; Strader, L.; Sade, N.; Weinstain, R.; Geisler, M.; Shani, E.
10.1101/2021.05.12.443788 — plant biology — Posted on 2021-05-13
2725 RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy
Song, K.; Edgar, K.; Hanan, E.; Hafner, M.; Oeh, J.; Merchant, M.; Sampath, D.; Nannini, M.; Hong, R.; Phu, L.; Forrest, W.; Stawiski, E.; schmidt, S.; Endres, N.; Guan, J.; Wallin, J.; Cheong, J.; Plise, E.; Phillips, G.; Salphati, L.; Heffron, T.; Olivero, A.; Malek, S.; Staben, S. T.; Kirkpatrick, D.; Dey, A.; Friedman, L.
10.1101/2021.05.12.442687 — cancer biology — Posted on 2021-05-13
2726 A novel cholinergic neural pathway and its role in the drug relapse
He, T.; Chen, W.; Fan, Y.; Xu, X.; Wang, Z.; Li, N.; Guo, H.; Lu, X.; Ge, F.; Guan, X.
10.1101/2021.05.12.443812 — neuroscience — Posted on 2021-05-13
2733 Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
Bhadra, P.; Dos Santos, S.; Gamayun, I.; Pick, T.; Ogbechi, J.; Hall, B. S.; Zimmermann, R.; Helms, V.; Simmonds, R. E.; Cavalie, A.
10.1101/2021.05.12.443793 — biochemistry — Posted on 2021-05-13
2735 Clone expansion of mutation-driven clonal hematopoiesis is associated with aging and metabolic dysfunction in individuals with obesity
van Deuren, R. C.; Andersson-Assarsson, J. C.; Kristensson, F. M.; Steehouwer, M.; Sjöholm, K.; Svensson, P.-A.; Peterse, M.; Gilissen, C.; Taube, M.; Jacobson, P.; Perkins, R.; Brunner, H. G.; Netea, M. G.; Peltonen, M.; Carlsson, B.; Hoischen, A.; Carlsson, L. M.
10.1101/2021.05.12.443095 — genomics — Posted on 2021-05-13
2742 The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants
Rayani, K.; Hantz, E.; Haji-Ghassemi, O.; Li, A. Y.; Spuches, A. M.; Van Petegem, F.; Solaro, R. J.; Lindert, S.; Tibbits, G. F.
10.1101/2021.05.12.443789 — cell biology — Posted on 2021-05-13
2745 microRNA-138 controls hippocampal interneuron function and short-term memory
Schratt, G.; Daswani, R.; Gilardi, C.; Soutschek, M.; Weiss, K.; Bicker, S.; Fiore, R.; Dieterich, C.; Germain, P.-L.; Winterer, J.
10.1101/2021.05.12.443573 — neuroscience — Posted on 2021-05-13
2746 Fluid intelligence and naturalistic task impairments after focal brain lesions
Smith, V.; Pinasco, C.; Achterberg, J.; Mitchell, D. J.; Das, T.; Roca, M.; Duncan, J.
10.1101/2021.05.12.443802 — neuroscience — Posted on 2021-05-13
2750 A graphical, interactive and GPU-enabled workflow to process long-read sequencing data
Reddy, S.; Hung, L.-H.; Sala-Torra, O.; Radich, J.; Yeung, C. C.; Yeung, K. Y.
10.1101/2021.05.11.443665 — bioinformatics — Posted on 2021-05-13
2752 Remote spatially variant debiased profiling of cell and tissue mechanical properties
Mason, J. H.; Luo, L.; Reinwald, Y.; Taffetani, M.; Hallas-Potts, A.; Herrington, C. S.; Srsen, V.; Lin, C.-J.; Barroso, I. A.; Zhang, Z.; Zhang, Z.; Ghag, A. K.; Yang, Y.; Waters, S.; El Haj, A. J.; Bagnaninchi, P.
10.1101/2021.05.12.443111 — bioengineering — Posted on 2021-05-13
2753 Climate risks to carbon sequestration in US forests
Anderegg, W. R. L.; Chegwidden, O. S.; Badgley, G.; Trugman, A. T.; Cullenward, D.; Abatzoglou, J. T.; Hicke, J. A.; Freeman, J.; Hamman, J. J.
10.1101/2021.05.11.443688 — ecology — Posted on 2021-05-13
2757 A clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations
Mircea, M.; Hochane, M.; Fan, X.; Chuva de Sousa Lopes, S. M.; Garlaschelli, D.; Semrau, S.
10.1101/2021.05.11.443685 — bioinformatics — Posted on 2021-05-13
2759 Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis
Katyal, P.; Hettinghouse, A.; Meleties, M.; Chen, C.; Cui, M.; Sun, G.; Hasan, S.; Menon, R.; Lin, B.; Regatte, R.; Montclare, J. K.; Liu, C.
10.1101/2021.05.12.443716 — bioengineering — Posted on 2021-05-13
2762 Genetic diversity, distribution and domestication history of the neglected GGAtAt genepool of wheat
Badaeva, E. D.; Konovalov, F. A.; Knuepffer, H.; Fricano, A.; Ruban, A. S.; Kehel, Z.; Zoshchuk, S. A.; Surzhikov, S. A.; Neumann, K.; Graner, A.; Hammer, K.; Filatenko, A. A.; Bogaard, A.; Jones, G.; Ozkan, H.; Kilian, B.
10.1101/2021.01.10.426084 — evolutionary biology — Posted on 2021-05-13
2764 An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
Simon, C. S.; Funaya, C.; Bauer, J.; Voss, Y.; Machado, M.; Penning, A.; Klaschka, D.; Cyrklaff, M.; Kim, J.; Ganter, M.; Guizetti, J.
10.1101/2021.03.12.435157 — cell biology — Posted on 2021-05-13
2767 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Lauron, E.; Montiel-Ruiz, M.; Spreafico, R.; Noack, J.; Czudnochowski, N.; Sahakyan, A.; Pinto, D.; Saliba, C.; Delotta, E.; Park, A.; Cameroni, E.; Ledoux, S.; Werts, A.; Colas, C.; Soriaga, L.; Telenti, A.; Purcell, L. A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.
10.1101/2021.03.09.434607 — immunology — Posted on 2021-05-13
2768 Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost
Sheward, D. J.; Mandolesi, M.; Urgard, E.; Kim, C.; Hanke, L.; Perez Vidakovics, L.; Pankow, A.; Smith, N. L.; Castro Dopico, X.; McInerney, G. M.; Coquet, J. M.; Karlsson Hedestam, G.; Murrell, B.
10.1101/2021.04.03.438330 — immunology — Posted on 2021-05-13
2769 Cortical ripples provide the conditions for consolidation during NREM sleep in humans
Dickey, C. W.; Verzhbinsky, I. A.; Jiang, X.; Rosen, B. Q.; Kajfez, S.; Eskandar, E. N.; Gonzalez-Martinez, J.; Cash, S. S.; Halgren, E.
10.1101/2021.05.11.443637 — neuroscience — Posted on 2021-05-13
2773 Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in human and mice
Huang, Z.-L.; Chen, C.-R.; Zhong, Y.-H.; Jiang, S.; Xu, W.; Xiao, L.; Wang, Z.; Qu, W.-M.
10.1101/2021.05.11.443607 — neuroscience — Posted on 2021-05-13
2777 Relationship between Regional White Matter Hyperintensities and Alpha Oscillations in Older Adults
Kumral, D.; Cesnaite, E.; Beyer, F.; Hofmann, S. M.; Hensch, T.; Sander, C.; Hegerl, U.; Haufe, S.; Villringer, A.; Witte, V.; Nikulin, V.
10.1101/2020.09.04.283200 — neuroscience — Posted on 2021-05-13
2786 Lipid Droplets and Ferritin Heavy Chain: a Devilish Liaison in Cancer Radioresistance
Tirinato, L.; Marafioti, M. G.; Pagliari, F.; Jansen, J.; Aversa, I.; Hanley, R.; Nistico, C.; Garcia-Calderon, D.; Genard, G.; Guerreiro, J. F.; Costanzo, F. S.; Seco, J.
10.1101/2021.05.11.443559 — cancer biology — Posted on 2021-05-13
2787 Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment
Shannon, M.; Baltayeva, J.; Castellana, B.; Wachter, J.; Yoon, S.; Treissman, J.; Le, H. T.; Lavoie, P.; Beristain, A. G.
10.1101/2021.03.27.437349 — developmental biology — Posted on 2021-05-13
2790 Inferring population structure in biobank-scale genomic data
Chiu, A. M.; Molloy, E. K.; Tan, Z.; Talwalkar, A.; Sankararaman, S.
10.1101/2021.05.11.443705 — bioinformatics — Posted on 2021-05-13
2801 Fluorescence-Activated Droplet Sorting of Polyethylene terephthalate Degrading Enzymes
Qiao, Y.; Hu, R.; Chen, D.; Wang, L.; Fu, Y.; Li, C.; Dong, Z.; Weng, Y.; Du, W.
10.1101/2021.05.12.443719 — microbiology — Posted on 2021-05-12
2802 Patterns of serum immune biomarkers during elephant endotheliotropic herpesvirus viremia in Asian and African elephants
Edwards, K. L.; Latimer, E.; Siegal-Willott, J.; Kiso, W.; Padilla, L.; Sanchez, C.; Schmitt, D.; Brown, J.
10.1101/2021.05.12.443748 — immunology — Posted on 2021-05-12
2807 Coil-to-Helix Transition at the Nup358-BicD2 Interface for Dynein Recruitment and Activation
Gibson, J. M.; Cui, H.; Ali, M. Y.; Zhao, X.; Debler, E. W.; Zhao, J.; Trybus, K. M.; Solmaz, S. R.; Wang, C.
10.1101/2021.05.06.443034 — biophysics — Posted on 2021-05-12
2811 Delayed DNA replication in haploid human embryonic stem cells
Edwards, M. M.; Zuccaro, M. V.; Sagi, I.; Ding, Q.; Vershkov, D.; Benvenisty, N.; Egli, D.; Koren, A.
10.1101/2021.05.11.443666 — genomics — Posted on 2021-05-12
2812 TNF drives AKI-to-CKD transition downstream of proximal tubule EGFR
Abdelmageed, M. M.; Kefaloyianni, E.; Arthanarisami, A.; Khamissi, F.; Atkinson, J. J.; Herrlich, A.
10.1101/2021.04.29.442002 — cell biology — Posted on 2021-05-12
2814 Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp)
Suzuki, M.; Norizuki, C.; Wachino, J.-i.; Kawamura, K.; Nagano, N.; Nagano, Y.; Hayashi, W.; Kimura, K.; Doi, Y.; Arakawa, Y.
10.1101/2021.05.11.443713 — microbiology — Posted on 2021-05-12
2815 Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores
Doorduijn, D. J.; Heesterbeek, D. A. C.; Ruyken, M.; de Haas, C. J. C.; Stapels, D. A. C.; Aerts, P. C.; Rooijakkers, S. H. M.; Bardoel, B. W.
10.1101/2021.05.12.443779 — microbiology — Posted on 2021-05-12
2819 Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation
Cole, S.; Chandra, R.; Harris, M.; Patel, I.; Wang, T.; Kim, H.; Jensen, L.; Russo, S.; Turecki, G.; Gancarz-Kausch, A.; Dietz, D.; Lobo, M. K.
10.1101/2020.06.27.175349 — neuroscience — Posted on 2021-05-12
2820 Absolute proteome quantification in the gas-fermenting acetogen Clostridium autoethanogenum
Valgepea, K.; Talbo, G.; Takemori, N.; Takemori, A.; Ludwig, C.; Mueller, A.; Tappel, R.; Kopke, M.; Simpson, S. D.; Nielsen, L. K.; Marcellin, E.
10.1101/2021.05.11.443690 — systems biology — Posted on 2021-05-12
2824 Analysis of the Neurotropic and Anti-inflammatory Effects of Neuroelectrode Functionalization with a Heparan Sulphate Mimetic
Vallejo Giraldo, C.; Mohand, O. O.; Huynh, M. B.; Trotier, A.; Krukiewicz, K.; Pallipurath, A. R.; Flannery, A.; Kilcoyne, M.; Pandit, A.; Papy-Garcia, D.; Biggs, M.
10.1101/2021.05.11.443655 — bioengineering — Posted on 2021-05-12
2826 Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain.
DESAI, M. M.; Sharma, J.; Slusarczyk, A. L.; Chapin, A.; Wisniowska, A.; Ohlendorf, R.; Sur, M.; Jasanoff, A.
10.1101/2021.05.11.443603 — bioengineering — Posted on 2021-05-12
2827 High throughput single-cell genome sequencing gives insights into the generation andevolution of mosaic aneuploidy in Leishmania donovani
Negreira, G. H.; Monsieurs, P.; Imamura, H.; Maes, I.; Kuk, N.; Yagoubat, A.; Van den Broeck, F.; Sterkers, Y.; Dujardin, J.-C.; Domagalska, M. A.
10.1101/2021.05.11.443577 — genomics — Posted on 2021-05-12
2828 The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ
Nachmanson, D.; Officer, A.; Mori, H.; Gordon, J.; Evans, M. F.; Steward, J.; Yao, H.; O'Keefe, T.; Hasteh, F.; Stein, G. S.; Jepsen, K.; Weaver, D. L.; Hirst, G.; Sprague, B. L.; Esserman, L. J.; Borowsky, A. D.; Stein, J. L.; Harismendy, O.
10.1101/2021.05.11.443641 — genomics — Posted on 2021-05-12
2830 Set4 coordinates the activity of histone deacetylases and regulates stress-responsive gene expression within subtelomeric regions in yeast
Jethmalani, Y.; Tran, K.; Jaiswal, D.; Jezek, M.; Ramos, M.; Amos, S.; Garcia, E. J.; Negesse, M. Y.; Sun, W.; Park, D.; Green, E. M.
10.1101/2021.05.11.443697 — genetics — Posted on 2021-05-12
2834 The recent evolutionary rescue of a staple crop depended on over half a century of global germplasm exchange
Muleta, K. T.; Felderhoff, T.; Winans, N.; Walstead, R.; Charles, J. R.; Armstrong, J. S.; Mamidi, S.; Plott, C.; Vogel, J. P.; Lemaux, P. G.; Mockler, T. C.; Grimwood, J.; Schmutz, J.; Pressoir, G.; Morris, G. P.
10.1101/2021.05.11.443651 — evolutionary biology — Posted on 2021-05-12
2836 Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration.
Law, A.-L.; Jalal, S.; Pallett, T.; Mosis, F.; Guni, A.; Brayford, S.; Yolland, L.; Marcotti, S.; Levitt, J.; Poland, S.; Rowe-Sampson, M.; Jandke, A.; Koechl, R.; Pula, G.; Ameer-Beg, S. M.; Stramer, B. M.; Krause, M.
10.1101/2020.05.11.083030 — cell biology — Posted on 2021-05-12
2838 Dissecting and Tuning Primer Editing by Proofreading Polymerases
Gohl, D. M.; Auch, B.; Certano, A.; LeFrancois, B.; Bouevitch, A.; Doukhanine, E.; Fragel, C.; Macklaim, J.; Hollister, E.; Garbe, J.; Beckman, K. B.
10.1101/2021.05.11.443694 — molecular biology — Posted on 2021-05-12
2841 The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in Plasmodium sporozoite motility
Balaban, A.; Kanatani, S.; Mitra, J.; Gregory, J.; Vartak, N.; Sinnis-Bourozikas, A.; Frischknecht, F.; Ha, T.; Sinnis, P.
10.1101/2021.05.12.443759 — microbiology — Posted on 2021-05-12
2842 Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents
Zarkoob, H.; Allue-Guardia, A.; Chen, Y.-C.; Jung, O.; Vilanova, A. G.; Song, M.; Park, J.-G.; Oladunni, F.; Miller, J.; Tung, Y.-T.; Kosik, I.; Schultz, D.; yewdell, j.; Torrelles, J. B.; Martinez-Sobrido, L.; Cherry, S.; Ferrer, M.; Lee, E. M.
10.1101/2021.05.11.443693 — microbiology — Posted on 2021-05-12
2844 A novel lineage of polyomaviruses identified in bark scorpions
Schmidlin, K.; Kraberger, S.; Cook, C.; DeNardo, D. F.; Fontenele, R. S.; Van Doorslaer, K.; Martin, D. P.; Buck, C. B.; Varsani, A.
10.1101/2021.05.12.443864 — microbiology — Posted on 2021-05-12
2845 KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in P. falciparum-infected erythrocytes
Sanchez, C. P.; Patra, P.; Chang, S.-Y.; Karathanasis, C.; Hanebutte, L.; Kilian, N.; Cyrklaff, M.; Heilemann, M.; Schwarz, U. S.; Kudryashev, M.; Lanzer, M.
10.1101/2021.05.12.443751 — microbiology — Posted on 2021-05-12
2846 Neutralization potential of Covishield vaccinated individuals against B.1.617.1
Yadav, P.; Sapkal, G. N.; Abraham, P.; Deshpande, G.; Nyayanit, D.; Patil, D. Y.; Gupta, N.; Sahay, R. R.; Shete, A.; Kumar, S.; Panda, S.; Bhargava, B.
10.1101/2021.05.12.443645 — immunology — Posted on 2021-05-12
2847 CRISPR activation and interference screens in primary human T cells decode cytokine regulation
Schmidt, R.; Steinhart, Z.; Layeghi, M.; Freimer, J. W.; Nguyen, V. Q.; Blaeschke, F.; Marson, A.
10.1101/2021.05.11.443701 — immunology — Posted on 2021-05-12
2848 Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
Sun, S.; Cai, Y.; Song, T.-Z.; Pu, Y.; Cheng, L.; Xu, H.; Meng, C.; Lin, Y.; Sun, J.; Zhang, S.; Gao, Y.; Han, J.-B.; Feng, X.-L.; Yu, D.-D.; Zhu, Y.; Gao, P.; Tang, H.; Zhao, J.; Yang, J.; Hu, Z.; Zhang, Z.; Fu, Y.-X.; Zheng, Y.-T.; Peng, H.
10.1101/2021.05.12.443228 — immunology — Posted on 2021-05-12
2851 Low competitive status elicits aggression in healthy young men: behavioral and neural evidence
Buades-Rotger, M.; Goettlich, M.; Weiblen, R.; Petereit, P.; Scheidt, T.; Keevil, B. G.; Kraemer, U. M.
10.1101/2020.06.20.162586 — neuroscience — Posted on 2021-05-12
2852 Revisiting the Neural Architecture of Adolescent Decision-Making: Univariate and Multivariate Evidence for System-Based Models
Guassi Moreira, J. F.; Mendez Leal, A. S.; Waizman, Y. H.; Saragosa-Harris, N.; Ninova, E.; Silvers, J. A.
10.1101/2020.11.26.400416 — neuroscience — Posted on 2021-05-12
2855 Arabidopsis Poly(ADP-ribose)-binding protein RCD1 interacts with Photoregulatory Protein Kinases in nuclear bodies
Vainonen, J. P.; Shapiguzov, A.; Krasensky-Wrzaczek, J.; Gossens, R.; De Masi, R.; Danciu, I.; Battchikova, N.; Jonak, C.; Wirthmueller, L.; Wrzaczek, M.; Kangasjärvi, J.
10.1101/2020.07.02.184937 — plant biology — Posted on 2021-05-12
2859 Bayesian Additive Regression Trees for Genotype by Environment Interaction Models
Sarti, D. A.; Prado, E. B.; Inglis, A.; dos Santos, A. A. L.; Hurley, C.; Moral, R. d. A.; Parnell, A.
10.1101/2021.05.07.442731 — bioinformatics — Posted on 2021-05-12
2860 Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations
Yang, T.-J.; Yu, P.-Y.; Chang, Y.-C.; Liang, K.-H.; Tso, H.-C.; Ho, M.-R.; Chen, W.-Y.; Lin, H.-T.; Wu, H.-C.; Hsu, S.-T. D.
10.1101/2021.05.11.443686 — biochemistry — Posted on 2021-05-12
2866 Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19
Kaplonek, P.; Wang, C.; Bartsch, Y.; Fischinger, S.; Gorman, M. J.; Bowman, K.; Kang, J.; Dayal, D.; Martin, P.; Nowak, R.; Hsieh, C.-L.; Feldman, J.; Juelg, B.; Nilles, E.; Musk, E. R.; Menon, A. S.; Fischer, E. S.; McLellan, J. S.; Schmidt, A.; Goldberg, M. B.; Filbin, M.; Hacohen, N.; Lauffenburger, D. A.; Alter, G.
10.1101/2021.05.11.443609 — immunology — Posted on 2021-05-12
2867 Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B
Liu, J.; Budylowski, P.; Samson, R.; Griffin, B. D.; Babuadze, G.; Rathod, B.; Colwill, K.; Abioye, J. A.; Schwartz, J. A.; Law, R.; Yip, L.; Ahn, S. K.; Chau, S.; Naghibosadat, M.; Arita, Y.; Hu, Q.; Yue, F. Y.; Banerjee, A.; Mossman, K.; Mubareka, S.; Kozak, R. A.; Pollanen, M. S.; Orozco, N. M.; Gingras, A.-C.; Marcusson, E. G.; Ostrowski, M. A.
10.1101/2021.05.11.443286 — immunology — Posted on 2021-05-12
2868 Exploring MEG brain fingerprints: evaluation, pitfalls and interpretations
Sareen, E.; Zahar, S.; Van De Ville, D.; Gupta, A.; Griffa, A.; Amico, E.
10.1101/2021.02.15.431253 — neuroscience — Posted on 2021-05-12
2871 Restoring persistent accessibility to memories after sleep deprivation-induced amnesia
Bolsius, Y. G.; Heckman, P.; Raven, F.; Meijer, E. L.; Kas, M. J.; Ramirez, S.; Meerlo, P.; Havekes, R.
10.1101/2021.05.11.443364 — neuroscience — Posted on 2021-05-12
2874 Retro Drug Design: From Target Properties to Molecular Structures
Wang, Y.; Michael, S.; Huang, R.; Zhao, J.; Recabo, K.; Bougie, D.; Shu, Q.; Shinn, P.; Sun, H.
10.1101/2021.05.11.442656 — bioinformatics — Posted on 2021-05-12
2876 Genetic Structure and Diversity of Banana Bunchy Top Virus (BBTV) in the Philippines
Mendoza, J.-V. S.; Dela Cueva, F. M.; Cortaga, C. Q.; Manohar, A. N. C.; Gardoce, R. R.; Lachica, G. C.; Gonzales, M. C.; Thomas, J. E.; Lantican, D. V.
10.1101/2021.05.11.442582 — genetics — Posted on 2021-05-12
2877 Hybridization underlies localized trait evolution in cavefish
Moran, R. L.; Jaggard, J. B.; Roback, E. Y.; Rohner, N.; Kowalko, J. E.; Ornelas-Garcia, P.; McGaugh, S. E.; Keene, A. C.
10.1101/2021.05.11.443489 — evolutionary biology — Posted on 2021-05-12
2879 Simultaneous Morphology, Motility and Fragmentation Analysis of Live Individual Sperm Cells for Male Fertility Evaluation
Ben-Yehuda, K.; Mirsky, S. K.; Levi, M.; Barnea, I.; Meshulach, I.; Kontente, S.; Benvaish, D.; Cur-Cycowicz, R.; Nygate, Y. N.; Shaked, N. T.
10.1101/2021.05.11.443542 — bioengineering — Posted on 2021-05-12
2880 No pervasive size trend in global community dynamics.
Terry, C.; Dinner O'Sullivan, J. L.; Rossberg, A. G.
10.1101/2021.05.11.443574 — ecology — Posted on 2021-05-12
2883 LNetReduce: tool for reducing linear dynamicnetworks with separated time scales
Buffard, M.; Desoeuvres, A.; Naldi, A.; Requilé, C.; Zinovyev, A.; Radulescu, O.
10.1101/2021.05.11.443578 — systems biology — Posted on 2021-05-12
2887 A history of previous childbirths is linked to women's white matter brain age in midlife and older age
Voldsbekk, I.; Barth, C.; Maximov, I. I.; Kaufmann, T.; Beck, D.; Richard, G.; Moberget, T.; Westlye, L. T.; de Lange, A.-M. G.
10.1101/2020.11.20.391698 — neuroscience — Posted on 2021-05-12
2888 Smaller Hippocampal Volume among Black and Latinx Youth Living in High-Stigma Contexts
Hatzenbuehler, M. L.; Weissman, D. G.; McKetta, S.; Lattanner, M. R.; Ford, J. V.; Barch, D. M.; McLaughlin, K. A.
10.1101/2020.10.09.333328 — neuroscience — Posted on 2021-05-12
2889 Age and Sex Effects on Advanced White Matter Microstructure Measures in 15,628 Older Adults: A UK Biobank Study
Lawrence, K. E.; Nabulsi, L.; Santhalingam, V.; Abaryan, Z.; Villalon-Reina, J. E.; Nir, T. M.; Ba Gari, I.; Zhu, A. H.; Haddad, E.; Muir, A. M.; Laltoo, E.; Jahanshad, N.; Thompson, P. M.
10.1101/2020.09.18.304345 — neuroscience — Posted on 2021-05-12
2890 Super-Resolution Imaging by Dual Iterative Structured Illumination Microscopy
Loeschberger, A.; Novikau, Y.; Netz, R.; Spindler, M.-C.; Benavente, R.; Klein, T.; Sauer, M.; Kleppe, I.
10.1101/2021.05.12.443720 — biophysics — Posted on 2021-05-12
2894 Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Brereton, C. J.; Yao, L.; Zhou, Y.; Vukmirovic, M.; Bell, J. A.; Ridley, R. A.; Davies, E.; Dean, L. S. N.; Andriotis, O. G.; Conforti, F.; Mohammed, S.; Wallis, T.; Tavassoli, A.; Ewing, R.; Alzetani, A.; Marshall, B. G.; Fletcher, S.; Thurner, P. J.; Fabre, A.; Kaminski, N.; Richeldi, L.; Bhaskar, A.; Loxham, M.; Davies, D. E.; Wang, Y.; Jones, M.
10.1101/2021.05.11.443615 — cell biology — Posted on 2021-05-12
2895 Mechanosensitivity of amoeboid cells crawling in 3D
Gaertner, F.; Reis-Rodrigues, P.; de Vries, I.; Hons, M.; Aguilera, J.; Riedl, M.; Leithner, A.; Merrin, J.; Zheden, V.; Kaufmann, W. A.; Hauschild, R.; Sixt, M.
10.1101/2021.05.11.443058 — cell biology — Posted on 2021-05-12
2896 Cell-type specialization in the brain is encoded by specific long-range chromatin topologies
Winick-Ng, W.; Kukalev, A.; Harabula, I.; Zea Redondo, L.; Szabo, D.; Meijer, M.; Serebreni, L.; Zhang, Y.; Bianco, S.; Chiariello, A. M.; Irastorza Azcarate, I.; Fiorillo, L.; Musella, F.; Thieme, C. J.; Irani, E.; Torlai Triglia, E.; Kolodziejczyk, A. A.; Abentung, A.; Apostolova, G.; Paul, E. J.; Franke, V.; Kempfer, R.; Akalin, A.; Teichmann, S. A.; Dechant, G.; Ungless, M. A.; Nicodemi, M.; Welch, L.; Castelo-Branco, G.; Pombo, A.
10.1101/2020.04.02.020990 — molecular biology — Posted on 2021-05-12
2902 Tonic endocannabinoid signaling supports sleep through development in both sexes.
Martin, S. C.; Gay, S. M.; Armstrong, M. L.; Pazhayam, N. M.; Reisdorph, N.; Diering, G. H.
10.1101/2021.05.10.443432 — animal behavior and cognition — Posted on 2021-05-12
2903 The global rarity of intact coastal regions
Williams, B. A.; Watson, J.; Beyer, H.; Klein, C.; Montgomery, J.; Runting, R.; Roberson, L.; Halpern, B.; Grantham, H.; Kuempel, C.; Frazier, M.; Venter, O.; Wenger, A.
10.1101/2021.05.10.443490 — ecology — Posted on 2021-05-12
2904 Multiscale light-sheet organoid imaging framework
de Medeiros, G.; Ortiz, R.; Strnad, P.; Boni, A.; Maurer, F.; Liberali, P.
10.1101/2021.05.12.443427 — cell biology — Posted on 2021-05-12
2906 Autophagy gene-dependent intracellular immunity triggered by interferon-γ
McAllaster, M. R.; Bhushan, J.; Balce, D. R.; Orvedahl, A.; Park, A.; Hwang, S.; Sullender, M. E.; Sibley, D.; Virgin, H. W.
10.1101/2021.05.10.443539 — microbiology — Posted on 2021-05-12
2907 Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Heinzer, D.; Avar, M.; Pease, D. P.; Dhingra, A.; Yin, J.-A.; Schaper, E.; Dogancay, B.; Emmenegger, M.; Spinelli, A.; Maggi, K.; Chincisan, A.; Mead, S.; Hornemann, S.; Heutink, P.; Aguzzi, A.
10.1101/2021.01.28.428672 — neuroscience — Posted on 2021-05-12
2909 Arabidopsis AtPME2 has a pH-dependent processivity and control cell wall mechanical properties
Hocq, L.; Harbrylo, O.; Voxeur, A.; Pau-Roblot, C.; Safran, J.; Senechal, F.; Fournet, F.; Bassard, S.; Battu, V.; Demailly, H.; Tovar, J. C.; Pilard, S.; Marcelo, P.; Savary, B.; Mercadante, D.; Njo, M.; Beeckman, T.; Boudaoud, A.; Pelloux, J.; Lefebvre, V.
10.1101/2021.03.03.433777 — plant biology — Posted on 2021-05-12
2910 CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
Gupta, M.; Azumaya, C. M.; Moritz, M.; Pourmal, S.; Diallo, A.; Merz, G. E.; Jang, G. M.; Bouhaddou, M.; Fossati, A.; Brilot, A. F.; Diwanji, D.; Hernandez, E.; Herrera, N.; Kratochvil, H. T.; Lam, V. L.; Li, F.; Li, Y.; Nguyen, H. C.; Nowotny, C.; Owens, T. W.; Peters, J. K.; Rizo, A. N.; Schulze-Gahmen, U.; Smith, A. M.; Young, I. D.; Yu, Z.; Asarnow, D.; Billesbolle, C.; Campbell, M. G.; Chen, J.; Chen, K.-H.; Chio, U. S.; Dickinson, M. S.; Doan, L.; Jin, M.; Kim, K.; Li, J.; Li, Y.-L.; Linossi, E.; Liu, Y.; Lo, M.; Lopez, J.; Lopez, K. E.; Mancino, A.; Moss, F. R.; Paul, M. D.; Pawar, K. I
10.1101/2021.05.10.443524 — biophysics — Posted on 2021-05-12
2912 Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production
Wu, C.-Y.; Jhang, J.-G.; Lin, W.-S.; Lin, C.-W.; Chu, L.-A.; Chiang, A.-S.; Ho, H.-C.; Chan, C.-C.; Huang, S.-Y.
10.1101/2020.11.10.376046 — cell biology — Posted on 2021-05-12
2913 Simple cloning of large natural product biosynthetic gene clusters from Streptomyces by an engineered CRISPR/Cas12a system
Liang, M.; Liu, L.; Wang, W.; Zeng, X.; Liu, J.; Loganathan, K.; Zhu, G.; Bai, L.; Hou, C.; Chen, X.; Ouyang, L.; Liu, X.; Hu, B.; Xia, X.; Tong, Y.; Lou, C.; Alterovitz, G.; Tan, G.-Y.; Zhang, L.-X.
10.1101/2020.06.25.170191 — synthetic biology — Posted on 2021-05-12
2914 The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly
zur Lage, P.; Xi, Z.; Lennon, J.; Hunter, I.; Chan, W. K.; Bolado Carrancio, A.; von Kriegsheim, A.; Jarman, A. P.
10.1101/2021.05.11.443597 — cell biology — Posted on 2021-05-12
2915 Dynamical consequences of regional heterogeneity in the brains transcriptional landscape
Deco, G.; Kringelbach, M. L.; Arnatkeviciute, A.; Oldham, S.; Sabaroedin, K.; Rogasch, N. C.; Aquino, K. M.; Fornito, A.
10.1101/2020.10.28.359943 — neuroscience — Posted on 2021-05-12
2916 Aggregation is a context-dependent constraint on protein evolution
Monti, M.; Armaos, A.; Fantini, M.; Pastore, A.; Tartaglia, G. G.
10.1101/2021.05.10.443436 — bioinformatics — Posted on 2021-05-12
2919 Neural correlates of semantic number: A cross-linguistic investigation
Dunagan, D.; Zhang, S.; Li, J.; Bhattasali, S.; Pallier, C.; Whitman, J.; Yang, Y.; Hale, J.
10.1101/2021.05.11.443670 — neuroscience — Posted on 2021-05-11
2921 Chromatin landscape dynamics in development of the plant parasitic nematode Meloidogyne incognita
Hassanaly-Goulamhoussen, R.; De Carvalho Augusto, R.; Marteu-Garello, N.; Pere, A.; Favery, B.; Da Rocha, M.; Danchin, E. G. J.; Abad, P.; Grunau, C.; zurletto, L. P.-B.
10.1101/2021.05.11.443567 — genomics — Posted on 2021-05-11
2922 Maxicircle architecture and evolutionary insights into Trypanosoma cruzi complex
Berna, L.; Greif, G.; Pita, S.; Faral-Tello, P.; Diaz-Viraque, F.; De Souza, R. D. C. M.; Vallejo, G. A.; Alvarez-Valin, F.; Robello, C.
10.1101/2021.05.11.443566 — genomics — Posted on 2021-05-11
2926 Unraveling protein interactions between the temperate virus Bam35 and its Bacillus host using an integrative yeast two hybrid-high throughput sequencing approach
Lechuga, A.; Lood, C.; Berjon-Otero, M.; Del Prado, A.; Wagemans, J.; Noort, V. v.; Lavigne, R.; Salas, M.; Redrejo Rodriguez, M.
10.1101/2021.05.11.443545 — microbiology — Posted on 2021-05-11
2927 Microbiome dysbiosis regulates the level of energy production under anaerobic condition
Rahman, M. S.; Hoque, M. N.; Puspo, J. A.; Islam, M. R.; Das, N.; Siddique, M. A.; Hossain, M. A.; Sultana, M.
10.1101/2021.05.11.443548 — microbiology — Posted on 2021-05-11
2929 Benchmarking of tools for axon length measurement in individually-labeled projection neurons
Rubio-Teves, M.; Diez-Hermano, S.; Porrero, C.; Sanchez-Jimenez, A.; Prensa, L.; Clasca, F.; Garcia-Amado, M.; Villacorta-Atienza, J. A.
10.1101/2021.05.11.443544 — neuroscience — Posted on 2021-05-11
2933 High-dose drug heat map based on organoid array chip for drug selection with high safety and efficacy
Lee, S.-Y.; Teng, Y.; Son, M.; Ku, B.; Moon, H. S.; Tergaonkar, V.; Chow, P. K.-H.; Lee, D. W.; Nam, D.-H.
10.1101/2021.05.11.443550 — cancer biology — Posted on 2021-05-11
2936 Detecting the ecological footprint of selection
Luiselli, J.; Overcast, I.; Rominger, A.; Ruffley, M.; Morlon, H.; Rosindell, J.
10.1101/2021.05.11.442553 — ecology — Posted on 2021-05-11
2941 Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues
Ali, A.; Canaday, L. M.; Feldman, H. A.; Cevik, H.; Moran, M. T.; Rajaram, S.; Lakes, N.; Tuazon, J. A.; Seelamneni, H.; Kirshnamurthy, D.; Blass, E.; Barouch, D. H.; Waggoner, S. N.
10.1101/2021.05.11.443590 — immunology — Posted on 2021-05-11
2942 Spatiotemporal single cell transcriptomic analyzis of human gut macrophages revealsmultiple functional and niche-specific subsets
Domanska, D.; Majid, U.; Karlsen, V. T.; Merok, M. A.; Beitnes, A.-C.; Yaqub, S.; Bakkevold, E. S.; Jahnsen, F. L.
10.1101/2021.05.11.443586 — immunology — Posted on 2021-05-11
2943 The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritis
Fuentelsaz-Romero, S.; Barrio Alonso, C.; Garcia Campos, R.; Torres Torresano, M.; Muller, I.; Triguero-Martinez, A.; Nuno, L.; Villalba, A.; Garcia-Vicuna, R.; Jansen, G.; Miranda-Carus, M. E.; Gonzalez-Alvaro, I.; Puig-Kröger, A.
10.1101/2021.05.11.443581 — immunology — Posted on 2021-05-11
2944 Disrupted microglial iron homeostasis in progressive multiple sclerosis
Proto, J. D.; Zhang, M.; Ryan, S.; Yao, X.; Huang, Y.; Chang, Y.-C.; Dufault, M.; Christie, E.; Chomyk, A.; Saleh, J.; Sancho, J.; Hammond, T.; Trapp, B.; Ofengeim, D.
10.1101/2021.05.09.443127 — neuroscience — Posted on 2021-05-11
2950 Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-glycoprotein
Pulukuri, A. J.; Burt, A. J.; Opp, L. K.; McDowell, C. M.; Nielsen, A. E.; Mancini, R. J.
10.1101/2021.05.11.443528 — cancer biology — Posted on 2021-05-11
2958 O-GlcNAcylation reduces phase separation and aggregation of the EWS N-terminal low complexity region
Nosella, M. L.; Tereshchenko, M.; Pritisanac, I.; Chong, A.; Toretsky, J. A.; Lee, H. O.; Forman-Kay, J. D.
10.1101/2021.05.11.443654 — biochemistry — Posted on 2021-05-11
2959 Integrated phospho-proteogenomic and single-cell transcriptomic analysis of meningiomas establishes robust subtyping and reveals subtype-specific immune invasion
Blume, C.; Dogan, H.; Schweizer, L.; Peyre, M.; Doll, S.; Picard, D.; Sankowski, R.; Hovestadt, V.; Okonechnikov, K.; Sievers, P.; Patel, A.; Reuss, D.; Friedrich, M.; Stichel, D.; Schrimpf, D.; Beck, K.; Wirsching, H.-G.; Jungwirth, G.; Hanemann, C. O.; Lamszus, K.; Westphal, M.; Etminan, N.; Unterberg, A.; Mawrin, C.; Remke, M.; Ayrault, O.; Lichter, P.; Pfister, S. M.; Reifenberger, G.; Platten, M.; Milde, T.; Jones, D. T.; Grossmann, R.; Ram, Z.; Ratliff, M.; Herold-Mende, C.; Mallm, J.-P.; Neidert, M. C.; Wick, W.; Prinz, M.; Weller, M.; Mann, M.; Kalamarides, M.; von Deimling, A.; Schles
10.1101/2021.05.11.443369 — genomics — Posted on 2021-05-11
2961 Convergent loss of chemoreceptors across independent origins of slave-making in ants
Jongepier, E.; Seguret, A.; Labutin, A.; Feldmeyer, B.; Gstöttl, C.; Foitzik, S.; Heinze, J.; Bornberg-Bauer, E.
10.1101/2021.05.11.443570 — genomics — Posted on 2021-05-11
2962 Performance of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study
exRNAQC Consortium, ; Anckaert, J.; Avila Cobos, F.; Decock, A.; Deleu, J.; De Wever, O.; De Wilde, J.; Dhondt, B.; D'huyvetter, T.; Everaert, C.; Fierro, C.; Helsmoortel, H. H.; Hendrix, A.; Hulstaert, E.; Kuersten, S.; Mestdagh, P.; Morlion, A.; Nijs, N.; Nuytens, J.; Philippron, A.; Piofczyk, T.; Schoofs, K.; Schroth, G. P.; Vanden Eynde, E.; Vandesompele, J.; Van Maerken, T.; Van Paemel, R.; Verniers, K.; Yigit, N.
10.1101/2021.05.11.442610 — genomics — Posted on 2021-05-11
2964 The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly
zur Lage, P.; Xi, Z.; Lennon, J.; Hunter, I.; Chan, W. K.; Bolado Carrancio, A.; von Kriegsheim, A.; Jarman, A. P.
10.1101/2021.05.11.443597 — cell biology — Posted on 2021-05-11
2966 The Aspartyl Protease Ddi1 Is Essential for Erythrocyte Invasion by the Malaria Parasite
Ridewood, S.; Dirac-Svejstrup, B.; Howell, S. A.; Weston, A.; Lehmann, C.; Patel, A. P.; Collinson, L.; Bingham, R.; Powell, D.; Snijder, A.; Svejstrup, J. Q.; Deu, E.
10.1101/2021.05.11.443575 — cell biology — Posted on 2021-05-11
2969 Colicin-mediated transport of DNA through the iron transporter FepA
Cohen-Khait, R.; Harmalkar, A.; Pham, P.; Webby, M. N.; Housden, N. G.; Elliston, E.; Hopper, J. T.; Mohammed, S.; Robinson, C. V.; Gray, J. J.; Kleanthous, C.
10.1101/2021.05.11.443673 — microbiology — Posted on 2021-05-11
2970 Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.
Candela, M. E.; Allsop, D. J. P.; Carter, R. N.; Semple, F.; Kilanowski, F.; Webb, S.; Taggart, D.; Mullan, H. J. W.; McHugh, B. J.; Dockrell, D. H.; Davidson, D. J.; Allen, J. E.; Jenkins, S. J.; Morton, N. M.; Dorin, J. R.
10.1101/2021.05.06.442606 — immunology — Posted on 2021-05-11
2972 A Non-redundant Role for T cell-derived IL-22 in Antibacterial Defense of Colonic Crypts
Weaver, C. T.; Zindl, C. L.; Witte, S. J.; Laufer, V. A.; Gao, M.; Yue, Z.; Silberger, D. J.; Harbour, S. N.; Singer, J. R.; Pham, D.; Moseley, C. E.; Cai, B.; Turner, H.; Lund, F. E.; Vallance, B. A.; Rosenberg, A. F.; Chen, J. Y.; Hatton, R. D.
10.1101/2021.05.11.443677 — immunology — Posted on 2021-05-11
2973 Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV Associated Neurocognitive Disorders
Finkelstein, A.; Faiyaz, A.; Weber, M. T.; Qiu, X.; Uddin, M. N.; Zhong, J.; Schifitto, G.
10.1101/2021.05.06.443022 — neuroscience — Posted on 2021-05-11
2977 Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B
Yoo, C. Y.; Sang, Q.; He, J.; Qiu, Y.; Long, L.; Kim, R. J.-A.; Chong, E. G.; Hahm, J.; Morffy, N.; Zhou, P.; Strader, L. C.; Nagatani, A.; Mo, B.; Chen, X.; Chen, M.
10.1101/2021.05.11.443493 — plant biology — Posted on 2021-05-11
2981 SARS-CoV-2 Variant Identification Using a Genome Tiling Array and Genotyping Probes
Shimada, R.; Alden, E. N.; Hoff, K.; Ding, D.; Sun, J.; Halasz, A. M.; Zhou, W.; Edwards, J. S.
10.1101/2021.05.11.443659 — bioinformatics — Posted on 2021-05-11
2983 homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA
Haack, A. J.; Lim, F. Y.; Kennedy, D. S.; Day, J. H.; Adams, K. N.; Lee, J. J.; Berthier, E.; Theberge, A. B.
10.1101/2021.02.08.430337 — bioengineering — Posted on 2021-05-11
2985 Physiological and transcriptomic variability indicative of differences in key functions within a single coral colony
Drake, J.; Malik, A.; Popovits, Y.; Yosef, O.; Shamesh, E.; Stolarski, J.; Tchernov, D.; Sher, D.; Mass, T.
10.1101/2021.02.25.432919 — genomics — Posted on 2021-05-11
2987 Large-scale geographic survey provides insights into the colonization history of a major aphid pest on its cultivated apple host in Europe, North America and North Africa
Olvera-Vazquez, S. G.; Remoue, C.; Venon, A.; Rousselet, A.; Grandcolas, O.; Azrine, M.; Momont, L.; Galan, M.; Benoit, L.; David, G.; Alhmedi, A.; Belien, T.; Alins, G.; Franck, P.; Haddioui, A.; Jacobsen, S. K.; Andreev, R.; Simon, S.; Sigsgaard, L.; Guibert, E.; Tournant, L.; Gazel, F.; Mody, K.; Khachtib, Y.; Roman, A.; Ursu, T. M.; Zakharov, I. A.; Belcram, H.; Harry, M.; Roth, M.; Simon, J. C.; Oram, S.; Ricard, J. M.; Agnello, A.; Beers, E. H.; Engelman, J.; Balti, I.; Salhi-Hannachi, A.; Zhang, H.; Tu, H.; Mottet, C.; Barres, B.; Degrave, A.; Razmjou, J.; Giraud, T.; Falque, M.; Dapena
10.1101/2020.12.11.421644 — evolutionary biology — Posted on 2021-05-11
2989 Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability
Geijer, M.; Zhou, D.; Selvam, K.; Steurer, B.; Evers, B.; Mukherjee, C.; Cugusi, S.; van Toorn, M.; van der Woude, M.; Gong, W.; Janssens, R.; Raams, A.; Lebbink, J.; Geverts, B.; Plummer, D.; Bezstarosti, K.; Theil, A.; Mitter, R.; Houtsmuller, A.; Vermeulen, W.; Demmers, J.; Li, S.; Lans, H.; Bernards, R.; Svejstrup, J.; Ray Chaudhuri, A.; Wyrick, J.; Marteijn, J.
10.1101/2021.05.11.443558 — cell biology — Posted on 2021-05-11
2990 Linking carbohydrate structure with function in the human gut microbiome using hybrid metagenome assemblies
Ravi, A.; Troncoso-Rey, P.; Ahn-Jarvis, J.; Corbin, K. R.; Harris, S.; Harris, H.; Aydin, A.; Kay, G. L.; Le-Viet, T.; Gilroy, R.; PALLEN, M. J.; Page, A. J.; O'Grady, J.; Warren, F.
10.1101/2021.05.11.441322 — microbiology — Posted on 2021-05-11
2992 Efflux only impacts drug accumulation in actively growing cells
Whittle, E.; McNeil, H.; Trampari, E.; Webber, M. A.; Overton, T.; Blair, J. M. A.
10.1101/2021.05.11.443560 — microbiology — Posted on 2021-05-11
2996 Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis
Chin, W. H.; Kett, C.; Cooper, O.; Müseler, D.; Zhang, Y.; Bamert, R. S.; Patwa, R.; Woods, L. C.; Devendran, C.; Tiralongo, J.; Lithgow, T.; McDonald, M. J.; Neild, A.; Barr, J. J.
10.1101/2021.05.11.443681 — microbiology — Posted on 2021-05-11
2997 An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei
Bandini, G.; Damerow, S.; Sempaio Güther, M. L.; Guo, H.; Mehlert, A.; Beverley, S. M.; Ferguson, M. A. J.
10.1101/726117 — microbiology — Posted on 2021-05-11
3000 Cortical layer-specific modulation of neuronal activity after sensory deprivation due to spinal cord injury
Zaforas, M.; Rosa, J. M.; Alonso-Calvino, E.; Fernandez-Lopez, E.; Miguel-Quesada, C.; Oliviero, A.; Aguilar, J.
10.1101/2020.12.28.424612 — neuroscience — Posted on 2021-05-11
3003 FAIRSCAPE: A Framework for FAIR and Reproducible Biomedical Analytics
Levinson, M. A.; Niestroy, J.; Al Manir, S.; Fairchild, K. D.; Lake, D. E.; Moorman, J. R.; Clark, T.
10.1101/2020.08.10.244947 — bioinformatics — Posted on 2021-05-11
3004 Structure and mechanism of SARS-CoV-2 Spike N679-V687 deletion variant elucidate cell-type specific evolution of viral fitness
Gupta, K.; Toelzer, C.; Williamson, M. K.; Shoemark, D.; Oliveira, A. S. F.; Matthews, D. A.; Almuqrin, A.; Staufer, O.; Yadav, S. K. N.; Borucu, U.; Garzoni, F.; Fitzgerald, D.; Spatz, J.; Mulholland, A. J.; Davidson, A. D.; Schaffitzel, C.; Berger, I.
10.1101/2021.05.11.443384 — biochemistry — Posted on 2021-05-11
3007 DROP: Molecular voucher database for identification of Drosophila parasitoids
Lue, C.-H.; Buffington, M. L.; Scheffer, S.; Lewis, M.; Elliott, T. A.; Lindsey, A. R. I.; Driskell, A.; Jandova, A.; Kimura, M. T.; Carton, Y.; Kula, R. R.; Schlenke, T. A.; Mateos, M.; Govind, S.; Varaldi, J.; Guerrier, E.; Giorgini, M.; Wang, X.; Hoelmer, K.; Daane, K. M.; Abram, P. K.; Pardikes, N. A.; Brown, J. J.; THIERRY, M.; Poirie, M.; Goldstein, P.; Miller, S. E.; Tracey, D.; Davis, J. S.; Jiggins, F. M.; Wertheim, B.; Lewis, O.; Leips, J.; Staniczenko, P. P. A.; Hrcek, J.
10.1101/2021.02.09.430471 — genomics — Posted on 2021-05-11
3009 CdrS is a global transcriptional regulator influencing cell division in Haloferax volcanii
Liao, Y.; Vogel, V.; Hauber, S.; Bartel, J.; Alkhnbashi, O. S.; Maass, S.; Schwarz, T. S.; Backofen, R.; Becher, D.; Duggin, I. G.; Marchfelder, A.
10.1101/2021.05.11.443588 — microbiology — Posted on 2021-05-11
3010 Plant genetic effects on microbial hubs impact fitness across field trials
Brachi, B.; Filiault, D.; Whitehurst, H.; Darme, P.; Le Gars, P.; Le Mentec, M.; Morton, T. C.; Kerdaffrec, E.; Rabanal, F.; Anastasio, A.; Box, M. S.; Duncan, S.; Huang, F.; Novikova, P.; Perisin, M.; Tsuchimatsu, T.; Woolley, R.; Dean, C.; Nordborg, M.; Holm, S.; Bergelson, J.
10.1101/181198 — plant biology — Posted on 2021-05-11
3011 A widely distributed genus of soil Acidobacteria genomically enriched in biosynthetic gene clusters
Crits-Christoph, A.; Diamond, S.; Al-Shayeb, B.; Valentin-Alvarado, L.; Banfield, J. F.
10.1101/2021.05.10.443473 — microbiology — Posted on 2021-05-11
3013 Systematic tissue annotations of -omics samples by modeling unstructured metadata
Hawkins, N. T.; Maldaver, M.; Yannakopoulos, A.; Guare, L. A.; Krishnan, A.
10.1101/2021.05.10.443525 — bioinformatics — Posted on 2021-05-11
3014 Improved Genome Packaging Efficiency of AAV Vectors Using Rep Hybrids
Mietzsch, M.; Eddington, C.; Jose, A.; Hsi, J.; Chipman, P.; Henley, T.; Choudhry, M.; McKenna, R.; Agbandje-McKenna, M.
10.1101/2021.05.10.443533 — molecular biology — Posted on 2021-05-11
3018 Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis
Moriarty, R. V.; Rodgers, M.; Ellis-Connell, A.; Balgeman, A. J.; Larson, E. C.; Hopkins, F.; Chase, M. R.; Maiello, P.; Fortune, S.; Scanga, C. A.; O'Connor, S. L.
10.1101/2021.05.10.443538 — microbiology — Posted on 2021-05-11
3019 Design and immunogenicity of a Pan-SARS-CoV-2 synthetic DNA vaccine
Reed, C. C.; Schultheis, K.; Andrade, V. M.; Kalia, R.; Tur, J.; Schouest, B.; Elwood, D.; Walters, J. N.; Maricic, I.; Doan, A.; Vazquez, M.; Eblimit, Z.; Pezzoli, P.; Amante, D.; Yang, M.; Fader, J.; Ferrer, R.; Weiner, D. B.; Kim, J. J.; Humeau, L. M.; Ramos, S. J.; Smith, T. R.; Broderick, K. E.
10.1101/2021.05.11.443592 — immunology — Posted on 2021-05-11
3022 Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies
Cao, Y.; Choi, Y. K.; Frank, M.; Woo, H.; Park, S.-J.; Yeom, M. S.; Seok, C.; Im, W.
10.1101/2021.05.10.443519 — biophysics — Posted on 2021-05-11
3023 Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Kabinger, F.; Stiller, C.; Schmitzova, J.; Dienemann, C.; Hillen, H. S.; Höbartner, C.; Cramer, P.
10.1101/2021.05.11.443555 — biochemistry — Posted on 2021-05-11
3025 Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall
Dickey, C. W.; Verzhbinsky, I. A.; Jiang, X.; Rosen, B. Q.; Kajfez, S.; Stedelin, B.; Shih, J. J.; Ben-Haim, S.; Raslan, A. M.; Eskandar, E. N.; Gonzalez-Martinez, J.; Cash, S. S.; Halgren, E.
10.1101/2021.02.23.432582 — neuroscience — Posted on 2021-05-11
3026 Multi-omics characterization of mesenchymal stem/stromal cells for the identification of putative critical quality attributes
Maughon, T. S.; Shen, X.; Huang, D.; Michael, A. O. A.; Shockey, W. A.; Andrews, S. H.; McRae, J. M.; Platt, M. O.; Fernandez, F. M.; Edison, A. S.; Stice, S. L.; Marklein, R. A.
10.1101/2021.05.10.440010 — bioengineering — Posted on 2021-05-11
3029 Exosomal transmission of α-synuclein initiates Parkinson's disease-like pathology
Howitt, J.; Low, L. H.; Bouman, M.; Yang, J.; Gordon, S.; Hill, A.; Tan, S.-S.
10.1101/2021.05.10.443522 — neuroscience — Posted on 2021-05-11
3030 Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples in Alzheimer's disease
Ratner, M. H.; Downing, S. S.; Guo, O.; Odamah, K.; Stewart, T. M.; Kumaresan, V.; Robitsek, R. J.; Xia, W.; Farb, D. H.
10.1101/2021.05.10.443512 — neuroscience — Posted on 2021-05-11
3033 Multi-resolution deconvolution of spatial transcriptomics data reveals continuous patterns of inflammation
Lopez, R.; Li, B.; Keren-Shaul, H.; Boyeau, P.; Kedmi, M.; Pilzer, D.; Jelinski, A.; David, E.; Wagner, A.; Addadi, Y.; Jordan, M. I.; Amit, I.; Yosef, N.
10.1101/2021.05.10.443517 — bioinformatics — Posted on 2021-05-11
3034 High-Stability Polyimide-based Flexible Electrodes with IrOx to Interface the Mouse Vagus Nerve
Sun, T.; Falcone, J. D.; Crosfield, C.; Lopez, M. F.; Peragine, J.; Modi, R.; Sharma, R.; Baker, B.; Anderson, G.; Savani, S.; Li, C.; Chang, E. H.; Sohal, H.; Rieth, L.
10.1101/2021.05.10.442867 — bioengineering — Posted on 2021-05-11
3037 Astrocytic Regulation of Basal Ganglia Dopamine/D2-Dependent Behaviors
Mastrogiacomo, R.; Trigilio, G.; Dautan, D.; Devroye, C.; Ferretti, V.; Vitali, E.; Orso, G.; Marotta, R.; Maltese, F.; Piras, G.; Forgiarini, A.; Pacinelli, G.; Rothmond, D.; Waddington, J.; Drago, F.; De Luca, M. A.; Leggio, G. M.; Weickert, C.; Manago', F.; Papaleo, F.
10.1101/2021.05.11.443394 — neuroscience — Posted on 2021-05-11
3038 Kinesin-3 mediated delivery of presynaptic neurexin stabilizes growing dendritic spines and postsynaptic components in vivo
Oliver, D.; Ramachandran, S.; Philbrook, A.; Lambert, C. M.; Nguyen, K. C. Q.; Hall, D. H.; Francis, M.
10.1101/2021.05.11.443328 — neuroscience — Posted on 2021-05-11
3039 O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
Ciraku, L.; Bacigalupa, Z. A.; Ju, J.; Moeller, R. A.; Lee, R. H.; Smith, M. D.; Ferrer, C. M.; Trefely, S.; Doan, M. T.; Gocal, W. A.; D'Agostino, L.; Shi, W.; Jackson, J. G.; Katsetos, C. D.; Snyder, N. W.; Reginato, M. J.
10.1101/2021.05.10.443157 — cancer biology — Posted on 2021-05-11
3040 Aggregation is a context-dependent constraint on protein evolution
Monti, M.; Armaos, A.; Fantini, M.; Pastore, A.; Tartaglia, G. G.
10.1101/2021.05.10.443436 — bioinformatics — Posted on 2021-05-11
3043 Relative time constraints improve molecular dating
Szollosi, G. J.; Hoehna, S.; Williams, T. A.; Schrempf, D.; Daubin, V.; Boussau, B.
10.1101/2020.10.17.343889 — evolutionary biology — Posted on 2021-05-11
3044 Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
Martinez, D. R.; Schaefer, A.; Leist, S. R.; De la Cruz, G.; West, A.; Atochina-Vasserman, E. N.; Lindesmith, L. C.; Pardi, N.; Parks, R.; Barr, M.; Li, D.; Yount, B.; Saunders, K. O.; Weissman, D.; Haynes, B.; Montgomery, S. A.; Baric, R. S.
10.1101/2021.03.11.434872 — microbiology — Posted on 2021-05-11
3045 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Montiel-Ruiz, M.; Czudnochowski, N.; Cameroni, E.; Ledoux, S.; Colas, C.; Soriaga, L.; Telenti, A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.; Park, A.; Noack, J.; Delotta, E.; Saliba, C.; Pinto, D.; Sahakyan, A.; Spreafico, R.; Lauron, E.; Werts, A.; Purcell, L. A.
10.1101/2021.03.09.434607 — immunology — Posted on 2021-05-11
3048 Web-based Psychoacoustics: Hearing Screening, Infrastructure, and Validation
Mok, B. A.; Viswanathan, V.; Borjigin, A.; Singh, R.; Kafi, H. I.; Bharadwaj, H. M.
10.1101/2021.05.10.443520 — neuroscience — Posted on 2021-05-11
3049 The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis
Federico, A.; Pavel, A.; Moebus, L.; McKean, D.; del Giudice, G.; Fortino, V.; Smith, C.; Weidinger, S.; De Rinaldis, E.; Greco, D.
10.1101/2021.05.10.443441 — systems biology — Posted on 2021-05-11
3050 Explainable Sleep Stage Classification with Multimodal Electrophysiology Time-series
Ellis, C. A.; Zhang, R.; Carbajal, D. A.; Miller, R. L.; Calhoun, V. D.; Wang, M. D.
10.1101/2021.05.04.442658 — bioinformatics — Posted on 2021-05-11
3052 Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity
Gilchrist, J. J.; Makino, S.; Naranbhai, V.; Lau, E.; Danielli, S.; Hameiri-Bowen, D.; Lee, W.; Ng, E.; Whalley, J.; Knight, J. C.; Fairfax, B. P.
10.1101/2021.05.10.443088 — genetics — Posted on 2021-05-11
3054 RevGadgets: an R Package for visualizing Bayesian phylogenetic analyses from RevBayes
Tribble, C. M.; Freyman, W. A.; Lim, J. Y.; Landis, M. J.; Barido-Sottani, J.; Kopperud, B. T.; Höhna, S.; May, M. R.
10.1101/2021.05.10.443470 — evolutionary biology — Posted on 2021-05-11
3055 A secreted proteomic footprint for stem cell pluripotency
Lewis, P. A.; Silajdzic, E.; Smith, H.; Bates, N.; Smith, C. A.; Knight, D.; Denning, C.; Brison, D. R.; Kimber, S. J.
10.1101/2021.04.14.439804 — cell biology — Posted on 2021-05-11
3056 Cell-type specialization in the brain is encoded by specific long-range chromatin topologies
Winick-Ng, W.; Kukalev, A.; Harabula, I.; Zea Redondo, L.; Szabo, D.; Meijer, M.; Serebreni, L.; Zhang, Y.; Bianco, S.; Chiariello, A. M.; Irastorza Azcarate, I.; Thieme, C. J.; Sparks, T. M.; Carvalho, S.; Fiorillo, L.; Musella, F.; Irani, E.; Torlai Triglia, E.; Kolodziejczyk, A. A.; Abentung, A.; Apostolova, G.; Paul, E. J.; Franke, V.; Kempfer, R.; Akalin, A.; Teichmann, S. A.; Dechant, G.; Ungless, M. A.; Nicodemi, M.; Welch, L.; Castelo-Branco, G.; Pombo, A.
10.1101/2020.04.02.020990 — molecular biology — Posted on 2021-05-11
3057 Decentralized Brain Age Estimation using MRI Data
Basodi, S.; Raja, R.; Ray, B.; Gazula, H.; Liu, J.; Verner, E.; Calhoun, V. D.
10.1101/2021.05.10.443469 — neuroscience — Posted on 2021-05-11
3058 The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes
Griggs, R. B.; Nguyen, D. V. M.; Yermakov, L. M.; Jaber, J. M.; Shelby, J. N.; Steinbrunner, J. K.; Miller, J. A.; Gonzalez-Islas, C.; Wenner, P.; Susuki, K.
10.1101/2021.05.10.443439 — neuroscience — Posted on 2021-05-11
3059 mRNA-decapping associated DcpS enzyme controls critical steps of neuronal development
Salamon, I.; Palsule, G.; Luo, X.; Roque, A.; Tucai, S.; Khosla, I.; Volk, N.; Liu, W.; Cui, H.; Dal Pozzo, V.; Zalamea, P.; Jiao, X.; DArcangelo, G.; Hart, R. P.; Rasin, M.-R.; Kiledjian, M.
10.1101/2021.05.10.443481 — neuroscience — Posted on 2021-05-11
3063 Therapeutic reversal of prenatal pontine ID1 signaling in DIPG
Yadav, V. N.; Harris, M. K.; Messinger, D.; Thomas, C.; Cummings, J. R.; Yang, T.; Woo, R.; Siddaway, R.; Burkert, M.; Stallard, S.; Qin, T.; Mullan, B.; Siada, R.; Ravindran, R.; Niculcea, M.; Ginn, K.; Gener, M. A. H.; Dorris, K.; Vitanza, N. A.; Schmidt, S.; Spitzer, J.; Jiang, L.; Filbin, M.; Cao, X.; Castro, M.; Lowenstein, P.; Mody, R.; Chinnaiyan, A.; Desprez, P.-Y.; McAllister, S.; Hawkins, C.; Waszak, S.; Venneti, S.; Koschmann, C.
10.1101/2021.05.10.443452 — cancer biology — Posted on 2021-05-11
3065 Genomic Epidemiology with Mixed Samples
Mäklin, T.; Kallonen, T.; Alanko, J.; Samuelsen, O.; Hegstad, K.; Mäkinen, V.; Corander, J.; Heinz, E.; Honkela, A.
10.1101/2020.04.03.021501 — bioinformatics — Posted on 2021-05-11
3068 The genome of the cereal pest Sitophilus oryzae: a transposable element haven
Parisot, N.; Vargas-Chavez, C.; Goubert, C.; Baa-Puyoulet, P.; Balmand, S.; Beranger, L.; Blanc, C.; Bonnamour, A.; Boulesteix, M.; Burlet, N.; Calevro, F.; Callaerts, P.; Chancy, T.; Charles, H.; Colella, S.; Da Silva Barbosa, A.; Dell'Aglio, E.; Di Genova, A.; Febvay, G.; Gabaldon, T.; Galvao Ferrarini, M.; Gerber, A.; Gillet, B.; Hubley, R.; Hughes, S.; Jacquin-Joly, E.; Maire, J.; Marcet-Houben, M.; Masson, F.; Meslin, C.; Montagne, N.; Moya, A.; Ribeiro de Vasconcelos, A. T.; Richard, G.; Rosen, J.; Sagot, M.-F.; Smit, A. F.; Storer, J.; Vincent-Monegat, C.; Vallier, A.; Vigneron, A.; Zai
10.1101/2021.03.03.408021 — genomics — Posted on 2021-05-11
3070 Population genomics of Pocillopora corals: insights from RAD-sequencing
Aurelle, D.; Pratlong, M.; Oury, N.; Haguenauer, A.; Gelin, P.; Magalon, H.; Adjeroud, M.; Romans, P.; Vidal-Dupiol, J.; Claereboudt, M.; Nous, C.; Reynes, L.; Toulza, E.; Bonhomme, F.; Mitta, G.; pontarotti, P.
10.1101/2021.05.04.442552 — evolutionary biology — Posted on 2021-05-11
3074 N2O-respiring bacteria in biogas digestates for reduced agricultural emissions
Jonassen, K. R.; Hagen, L. H.; Vick, S.; Arntzen, M.; Eijsink, V. G. H.; Frostegard, A.; Lycus, P.; Molstad, L.; Bakken, L. R.
10.1101/2020.11.16.384990 — microbiology — Posted on 2021-05-11
3075 Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics.
Gurung, J. P.; Navvab Kashani, M.; Agarwal, S.; Peralta, G.; Gel, M.; Baker, M. A.
10.1101/2020.11.24.395772 — microbiology — Posted on 2021-05-11
3077 Mind blanking is associated with a rigid spatio-temporal profile in typical wakefulness
Mortaheb, S.; Klados, M. A.; Van Calster, L.; Boulakis, P. A.; Georgoula, K.; Majerus, S.; Demertzi, A.
10.1101/2021.05.10.443428 — neuroscience — Posted on 2021-05-11
3078 Glial Cell Responses to constant low Light exposure in Rat Retina.
Bruera, M. G.; Benedetto, M. M.; Guido, M. E.; Degano, A. L.; Contin, M. A.
10.1101/2021.05.10.443423 — neuroscience — Posted on 2021-05-11
3080 Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production
Zhuravleva, V.; Vaz Silva, J.; Zhu, M.; Gomes, P.; Silva, J. M.; Sousa, N.; Sotiropoulos, I.; Waites, C. L.
10.1101/2021.05.10.443354 — neuroscience — Posted on 2021-05-11
3082 SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation
Ghelman, J.; Grewing, L.; Windener, F.; Albrecht, S.; Zarbock, A.; Kuhlmann, T.
10.1101/2021.04.22.439972 — neuroscience — Posted on 2021-05-11
3083 Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma
Spiliopoulou, P.; Spear, S.; Mirza, H.; Garner, I.; Mcgarry, L.; Grundland-Freile, F.; Cheng, Z.; Ennis, D.; McNamara, S.; Natoli, M.; Mason, S.; Blyth, K.; Adams, P.; Roxburgh, P.; Fuchter, M.; Brown, R.; McNeish, I.
10.1101/2021.05.09.443282 — cancer biology — Posted on 2021-05-11
3095 Visualization of loop extrusion by DNA nanoscale tracing in single human cells
Beckwith, K. S.; Oedegaard Fougner, O.; Morero, N. R.; Barton, C.; Schueder, F.; Alexander, S.; Jungmann, R.; Birney, E.; Ellenberg, J.
10.1101/2021.04.12.439407 — cell biology — Posted on 2021-05-11
3101 Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation
Baca, S. C.; Singler, C.; Zacharia, S.; Seo, J.-H.; Morova, T.; Hach, F.; Ding, Y.; Schwarz, T.; Huang, C.-C. F.; Kalita, C.; Groha, S.; Pomerantz, M. M.; Wang, V.; Linder, S.; Sweeney, C. J.; Zwart, W.; Lack, N. A.; Pasaniuc, B.; Takeda, D. Y.; Gusev, A.; Freedman, M. L.
10.1101/2021.05.10.443466 — genetics — Posted on 2021-05-11
3102 Quantitative monitoring of nucleotide sequence data from genetic resources in context of their citation in the scientific literature
Lange, M.; Alako, B.; Cochrane, G.; Ghaffar, M.; Mascher, M.; Habekost, P.-K.; Hillebrand, U.; Scholz, U.; Zunder, F.; Freitag, J.; Scholz, A. H.
10.1101/2021.05.10.443393 — bioinformatics — Posted on 2021-05-11
3103 Adaptation to host cell environment during experimental evolution of Zika virus
Grass, V.; Hardy, E.; Kobert, K.; Talemi, S. R.; Decembre, E.; Guy, C.; Markov, P. V.; Kohl, A.; Paris, M.; Böckmann, A.; Munoz-Gonzalez, S.; Sherry, L.; Höfer, T.; Boussau, B.; Dreux, M.
10.1101/2020.12.28.424577 — microbiology — Posted on 2021-05-11
3105 Noise-Transfer2Clean: Denoising cryo-EM images based on noise modeling and transfer
Li, H.; Zhang, H.; Wan, X.; Yang, Z.; Li, C.; Li, J.; Han, R.; Zhu, P.; Zhang, F.
10.1101/2021.05.10.443396 — bioinformatics — Posted on 2021-05-10
3108 mSWI/SNF interacts with the ribosome and its inhibition/mutations alter translation and sensitize to mTOR/PI3K inhibitors
Ulicna, L.; Kimmey, S. C.; Weber, C. M.; Allard, G. M.; Bendall, S. C.; Crabtree, G.; Bean, G. R.; Van Rechem, C.
10.1101/2021.05.10.443459 — cancer biology — Posted on 2021-05-10
3109 An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET
Zagotta, W. N.; Sim, B. S.; Nhim, A. K.; Raza, M. M.; Evans, E. G.; Venkatesh, Y.; Jones, C. M.; Mehl, R. A.; Petersson, J.; Gordon, S. E.
10.1101/2021.05.10.443484 — biophysics — Posted on 2021-05-10
3111 Self-assembly of tessellated tissue sheets by growth and collision
Heinrich, M. A.; Alert, R.; Wolf, A. E.; Kosmrlj, A.; Cohen, D. J.
10.1101/2021.05.06.442983 — bioengineering — Posted on 2021-05-10
3113 Single cell transcriptomics and developmental trajectories of murine cranial neural crest cell fate determination and cell cycle progression
Ji, Y.; Zhang, S.; Reynolds, K.; Gu, R.; McMahon, M.; Islam, M.; Liu, Y.; Imai, T.; Donham, R.; Zhao, H.; Xu, Y.; Burkart-Waco, D.; Zhou, C.
10.1101/2021.05.10.443503 — developmental biology — Posted on 2021-05-10
3114 Orc6 at replication fork enables efficient mismatch repair
Lin, Y.-C.; Chakraborty, A.; Liu, D.; Mitra, J.; Kadyrova, L.; Hsu, R.; Arif, M.; Adusumilli, S.; Ha, T.; Kadyrov, F.; Prasanth, K. V.; Prasanth, S. G.
10.1101/2021.05.10.443400 — molecular biology — Posted on 2021-05-10
3115 Fungi hijack a plant apoplastic endoglucanase to release a ROS scavenging β-glucan decasaccharide to subvert immune responses
Chandrasekar, B.; Wanke, A.; Wawra, S.; Saake, P.; Mahdi, L.; Charura, N.; Neidert, M.; Malisic, M.; Thiele, M.; Dama, M.; Pauly, M.; Zuccaro, A.
10.1101/2021.05.10.443455 — microbiology — Posted on 2021-05-10
3118 Plant trait heterosis is quantitatively associated with expression heterosis of plastid ribosomal proteins
Birdseye, D.; De Boer, L.; Shen, Z.; Bai, H.; Zhou, P.; Schmelz, E. A.; Springer, N. M.; Briggs, S.
10.1101/2021.02.16.431485 — plant biology — Posted on 2021-05-10
3126 Quantitative monitoring of nucleotide sequence data from genetic resources in context of their citation in the scientific literature
Lange, M.; Alako, B.; Cochrane, G.; Ghaffar, M.; Mascher, M.; Habekost, P.-K.; Hillebrand, U.; Scholz, U.; Zunder, F.; Freitag, J.; Scholz, A. H.
10.1101/2021.05.10.443393 — bioinformatics — Posted on 2021-05-10
3127 A mammalian methylation array for profiling methylation levels at conserved sequences
Arneson, A.; Haghani, A.; Thompson, M. J.; Pellegrini, M.; Kwon, S. B.; Vu, H. T.; Yao, M.; Li, C. Z.; Lu, A. T.; Barnes, B.; Hansen, K. D.; Zhou, W.; Breeze, C.; Ernst, J.; Horvath, S.
10.1101/2021.01.07.425637 — bioinformatics — Posted on 2021-05-10
3128 E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
Ahel, J.; Fletcher, A. J.; Grabarczyk, D. B.; Roitinger, E.; Deszcz, L.; Lehner, A.; Virdee, S.; Clausen, T.
10.1101/2021.05.10.443411 — biochemistry — Posted on 2021-05-10
3131 An estimate of the deepest branches of the tree of life from ancient vertically-evolving genes
Moody, E. R. R.; Mahendrarajah, T. A.; Dombrowski, N.; Clark, J. W.; Petitjean, C.; Offre, P.; Szöllosi, G. J.; Spang, A.; Williams, T. A.
10.1101/2021.01.19.427276 — evolutionary biology — Posted on 2021-05-10
3132 Identifying drivers of spatio-temporal variation in survival in four blue tit populations
Bastianelli, O.; Robert, A.; Doutrelant, C.; de Franceschi, C.; Giovannini, P.; Charmantier, A.
10.1101/2021.01.28.428563 — ecology — Posted on 2021-05-10
3136 Growth-dependent heterogeneity in the DNA damage response in Escherichia coli
Jaramillo-Riveri, S.; Broughton, J.; McVey, A.; Pilizota, T.; Scott, M.; El Karoui, M.
10.1101/2021.05.06.442821 — cell biology — Posted on 2021-05-10
3137 Receptor binding may directly activate the fusion machinery in coronavirus spike glycoproteins
Wang, Y.; Fallon, L.; Raguette, L.; Budhan, S.; Belfon, K.; Stepanenko, D.; Helbock, S.; Varghese, S.; Simmerling, C.
10.1101/2021.05.10.443496 — molecular biology — Posted on 2021-05-10
3138 Extreme longevity of highly fecund termite queens achieved by mitochondrial and insulin upregulation without harmful lipid signatures or accumulation
Seite, S.; Harrison, M. C.; Sillam-Dusses, D.; Lupoli, R.; Van Dooren, T. J. M.; Robert, A.; Poissonnier, L.-A.; Lemainque, A.; Renault, D.; Acket, S.; Andrieu, M.; Viscarra, J.; Sul, H. S.; de Beer, Z. W.; Bornberg-Bauer, E.; Vasseur-Cognet, M.
10.1101/2021.05.10.443390 — molecular biology — Posted on 2021-05-10
3141 Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity
Su, H.; Lin, K.; Tiwari, D.; Healy, C.; Trujillo, C.; Liu, Y.; Ioerger, T. R.; Schnappinger, D.; Ehrt, S.
10.1101/2021.02.08.430271 — microbiology — Posted on 2021-05-10
3146 Text has been revised, image definition has been revised.
Viquez-Zamora, C.; Castro-Pacheco, S.; Vinas, M.; Bolanos-Villegas, P.
10.1101/2021.04.29.442045 — plant biology — Posted on 2021-05-10
3148 Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma
Davidson, S. M.; Heyman, J. E.; O'Brien, J. P.; Liu, A. C.; Schmidt, D. R.; Israelsen, W. J.; Dayton, T. L.; Sehgal, R.; Bronson, R.; Freinkman, E.; Mak, H.; Malstrom, S.; Bellinger, G.; Carracedo, A.; Pandolfi, P. P.; Courtney, K. D.; Jha, A.; DePinho, R. A.; Horner, J.; Thomas, C.; Cantley, L. C.; Loda, M.; Vander Heiden, M. G.
10.1101/2021.05.09.443334 — cancer biology — Posted on 2021-05-10
3154 Microbiome differential abundance methods produce disturbingly different results across 38 datasets
Nearing, J. T.; Douglas, G. M.; Hayes, M. G.; MacDonald, J.; Desai, D.; Allward, N.; Jones, C. M. A.; Wright, R.; Dhanani, A.; Comeau, A. M.; Langille, M. G. I.
10.1101/2021.05.10.443486 — bioinformatics — Posted on 2021-05-10
3155 ID-Seg: An Accurate and Reliable Infant Deep learning Segmentation Framework for Limbic Structures
Wang, Y.; Haghpanah, F. S.; Zhang, X.; Santamaria, K.; Alves, G. K. d. C. A.; Bruno, E.; Aw, N.; Maddocks, A.; Duarte, C. S.; Monk, C. E.; Laine, A.; Posner, J.
10.1101/2021.03.29.437045 — bioengineering — Posted on 2021-05-10
3156 Binding mechanism underlying FIH-1 suppression caused by the N-terminal disordered region of Mint3
Ten, T.; Nagatoishi, S.; Hoshino, M.; Nakayama, Y.; Seiki, M.; Sakamoto, T.; Tsumoto, K.
10.1101/2021.05.10.443412 — biochemistry — Posted on 2021-05-10
3158 Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa
Martinez, E. M.; Toelle, R.; Donauer, J.; Gretzmeier, C.; Bruckner-Tuderman, L.; Dengjel, J.
10.1101/2021.05.10.443425 — biochemistry — Posted on 2021-05-10
3164 SARS-COV-2 Recombinant Receptor-Binding-Domain (RBD) Induces Neutralising Antibodies Against Variant Strains of SARS-CoV-2 and SARS-CoV-1
Law, J. L. M.; Logan, M.; Joyce, M.; Landi, A.; Hockman, D.; Crawford, K.; Johnson, J.; LaChance, G.; Saffran, H.; Shields, J.; Hobart, E.; Brassard, R.; Arutyunova, E.; Pabbaraju, K.; Croxen, M.; Tipples, G.; Lemieux, M. J.; Tyrrell, D. L.; Houghton, M.
10.1101/2021.05.10.443438 — microbiology — Posted on 2021-05-10
3167 Vaginal Isolates of Candida glabrata are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae.
Fredericks, L. R.; Lee, M. D.; Eckert, H. R.; Li, S.; Shipley, M. A.; Roslund, C. R.; Boikov, D. A.; Kizer, E. A.; Sobel, J. D.; Rowley, P. A.
10.1101/2020.10.14.339788 — microbiology — Posted on 2021-05-10
3168 The polar flagellar transcriptional regulatory network in Vibrio campbellii deviates from canonical Vibrio species
Petersen, B. D.; Liu, M. S.; Podicheti, R.; Yang, A. Y.-P.; Simpson, C. A.; Hemmerich, C.; Rusch, D. B.; van Kessel, J.
10.1101/2021.05.10.443453 — microbiology — Posted on 2021-05-10
3169 The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in Mycobacteria
Donegan, R. K.; Copeland, J.; Edgha, S.; Brown, G.; Hale, O. F.; Mitra, A.; Yang, H.; Dailey, H. A.; Niederweis, M.; Jain, P.; Reddi, A. R.
10.1101/2021.05.10.443464 — microbiology — Posted on 2021-05-10
3170 The quorum-sensing systems of Vibrio campbellii DS40M4 and BB120 are genetically and functionally distinct
Simpson, C. A.; Petersen, B. D.; Haas, N.; Geyman, L.; Lee, A.; Podicheti, R.; Pepin, R.; Brown, L. C.; Rusch, D. B.; Manzella, M. P.; Papenfort, K.; van Kessel, J. C.
10.1101/2020.03.31.019307 — microbiology — Posted on 2021-05-10
3173 Mice alternate between discrete strategies during perceptual decision-making
Ashwood, Z. C.; Roy, N. A.; Stone, I. R.; International Brain Laboratory, T.; Churchland, A. K.; Pouget, A.; Pillow, J. W.
10.1101/2020.10.19.346353 — neuroscience — Posted on 2021-05-10
3174 On stability of Canonical Correlation Analysis and Partial Least Squares with application to brain-behavior associations
Helmer, M.; Warrington, S. D.; Mohammadi-Nejad, A.-R.; Ji, J. L.; Howell, A.; Rosand, B.; Anticevic, A.; Sotiropoulos, S. N.; Murray, J. D.
10.1101/2020.08.25.265546 — neuroscience — Posted on 2021-05-10
3175 Neuronal morphology and physiology, functional brain networks and memory in temporal lobe epilepsy
Douw, L.; Nissen, I. A.; Fitzsimmons, S. M.; Santos, F. A.; Hillebrand, A.; van Straaten, E. C.; Stam, C. J.; de Witt Hamer, P. C.; Baayen, J. C.; Klein, M.; Reijneveld, J. C.; Heyer, D. B.; Verhoog, M. B.; Wilbers, R.; Hunt, S.; Mansvelder, H. D.; Geurts, J. J.; de Kock, C. P.; Goriounova, N. A.
10.1101/2021.01.31.428369 — neuroscience — Posted on 2021-05-10
3178 Statistical testing in gene transcriptomic-neuroimaging associations: an evaluation of methods that assess spatial and gene specificity
Wei, Y.; de Lange, S. C.; Pijnenburg, R.; Scholtens, L. H.; Ardesch, D. J.; Watanabe, K.; Posthuma, D.; van den Heuvel, M. P.
10.1101/2021.02.22.432228 — neuroscience — Posted on 2021-05-10
3180 Phosphorylation-dependent routing of RLP44 towards brassinosteroid or phytosulfokine signalling
Garnelo Gomez, B.; Holzwart, E.; Kolbeck, A.; Shi, C.; Lozano-Duran, R.; Wolf, S.
10.1101/527754 — plant biology — Posted on 2021-05-10
3181 Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance
Cintas, C.; Douche, T.; Dantes, Z.; Mouton-Barbosa, E.; Bousquet, M.-P.; Cayron, C.; Therville, N.; Pont, F.; Ramos-Delgado, F.; Guyon, C.; Garmy-Susini, B.; Cappello, P.; Burlet-Schiltz, O.; Hirsch, E.; Gomez-Brouchet, A.; Thibault, B.; Reichert, M.; Guillermet-Guibert, J.
10.1101/2020.10.08.313833 — cancer biology — Posted on 2021-05-10
3182 Single-cell analysis reveals mechanisms of plasticity of leukemia initiating cells
Morris, V.; Marion, W.; Hughes, T.; Sousa, P.; Sensharma, P.; Pikman, Y.; Harris, M.; Shalek, A. K.; North, T.; Daley, G. Q.; Lummertz da Rocha, E.; Rowe, G.
10.1101/2020.04.29.066332 — cancer biology — Posted on 2021-05-10
3184 Chromatin-accessibility estimation of single-cell ATAC data with scOpen
Li, Z.; Kuppe, C.; Ziegler, S.; Cheng, M.; Kabgani, N.; Menzel, S.; Zenke, M.; Kramann, R.; Costa, I. G.
10.1101/865931 — bioinformatics — Posted on 2021-05-10
3187 Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β
Iwamoto, M.; Masuya, T.; Hosose, M.; Tagawa, K.; Ishibashi, T.; Yoshihara, E.; Downes, M.; Evans, R. M.; Matsushima, A.
10.1101/2021.05.10.443431 — biochemistry — Posted on 2021-05-10
3188 RAD51AP1 mediates RAD51 activity through nucleosome interaction
Pires, E.; Sharma, N.; Selemenakis, P.; Wu, B.; Huang, Y.; Alimbetov, D.; Zhao, W.; Wiese, C.
10.1101/2020.12.17.421636 — biochemistry — Posted on 2021-05-10
3191 In-solution buffer-free digestion for the analysis of SARS-CoV-2 RBD proteins allows a full sequence coverage and detection of post-translational modifications in a single ESI-MS spectrum
Espinosa, L. A.; Ramos, Y.; Andujar, I.; Torres, E. O.; Cabrera, G.; Martin, A.; Gonzalez, D.; Chinea, G.; Becquet, M.; Gonzalez, I.; Canaan-Haden, C.; Nelson, E.; Rojas, G.; Perez-Masson, B.; Perez-Martinez, D.; Boggiano, T.; Palacio, J.; Lozada-Chang, S. L.; Hernandez, L.; de la Luz, K. R.; Markku, S.; Marika, V.; Valdes-Balbin, Y.; Santana-Medero, D.; G. Rivera, D.; Verez Bencomo, V.; Emalfarb, M.; Tchelet, R.; Guillen, G.; Limonta, M.; Pimentel, E.; Ayala, M.; Besada, V.; Gonzalez, L. J.
10.1101/2021.05.10.443404 — biochemistry — Posted on 2021-05-10
3192 Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans
Akther, S.; Bezrucenkovas, E.; Li, L.; Sulkow, B.; Di, L.; Pante, D.; Martin, C. L.; Luft, B. J.; Qiu, W.
10.1101/2021.05.07.443114 — evolutionary biology — Posted on 2021-05-10
3193 Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response
Dickey, T. H.; Tang, W. K.; Butler, B.; Ouahes, T.; Orr-Gonzalez, S.; Salinas, N. D.; Lambert, L. E.; Tolia, N. H.
10.1101/2021.05.09.443238 — molecular biology — Posted on 2021-05-10
3194 Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation
Tabata, K.; Prasad, V.; Paul, D.; Lee, J.-Y.; Pham, M.-T.; Twu, W.-I.; Neufeldt, C. J.; Cortese, M.; Cerikan, B.; Tran, C. S.; Luechtenborg, C.; Vkovski, P.; Hoermann, K.; Mueller, A.; Zitzmann, C.; Haselmann, U.; Beneke, J.; Kaderali, L.; Erfle, H.; Thiel, V.; Lohmann, V.; Superti-Furga, G.; Bruegger, B.; Bartenschlager, R.
10.1101/2021.05.10.443480 — microbiology — Posted on 2021-05-10
3195 A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery
Pinto, D.; Sauer, M. M.; Czudnochowski, N.; Low, J. S.; Tortorici, M. A.; Housley, M. P.; Noack, J.; Walls, A. C.; Bowen, J. E.; Guarino, B.; Rosen, L. E.; di Iulio, J.; Jerak, J.; Kaiser, H.; Islam, S.; Jaconi, S.; Sprugasci, N.; Culap, K.; Abdelnabi, R.; Foo, C. S.-Y.; Coelmont, L.; Bartha, I.; Bianchi, S.; Silacci-Fregni, C.; Bassi, J.; Marzi, R.; Vetti, E.; Cassotta, A.; Ceschi, A.; Ferrari, P.; Cippa', P. E.; Giannini, O.; Ceruti, S.; Riva, A.; Benigni, F.; Cameroni, E.; Piccoli, L.; Pizzuto, M. S.; Smithey, M.; Hong, D.; Telenti, A.; Lempp, F. A.; Neyts, J.; Havenar-Daughton, C.; Lanzave
10.1101/2021.05.09.442808 — immunology — Posted on 2021-05-10
3196 Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant
Edara, V.-V.; Lai, L.; Sahoo, M.; Floyd, K.; Sibai, M.; Solis, D.; Flowers, M. W.; Hussaini, L.; Ciric, C. R.; Bechnack, S.; Stephens, K.; Mokhtari, E. B.; Mudvari, P.; Creanga, A.; Pegu, A.; Derrien-Colemyn, A.; Henry, A. R.; Gagne, M.; Graham, B. S.; Wrammert, J.; Douek, D. C.; Bortiz, E.; Pinsky, B. A.; Suthar, M.
10.1101/2021.05.09.443299 — immunology — Posted on 2021-05-10
3197 Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice
Zhang, Q.; Abdelmotilib, H. A.; Larson, T.; Keomanivong, C.; Conlon, M.; Aldridge, G.; Narayanan, N.
10.1101/2021.05.10.443485 — neuroscience — Posted on 2021-05-10
3198 Information transfer in mammalian glycan-based communication
Fuchsberger, F. F.; Kim, D.; Kagelmacher, M.; Wawrzinek, R.; Rademacher, C.
10.1101/2021.05.10.443458 — cell biology — Posted on 2021-05-10
3201 SARS-CoV-2 receptor ACE2 identifies immuno-hot tumors in breast cancer
Mei, J.; Cai, Y.; Xu, R.; Yu, X.; Chen, L.; Ma, T.; Gao, T.; Gao, F.; Zhu, Y.; Zhang, Y.
10.1101/2021.05.10.443377 — immunology — Posted on 2021-05-10
3206 AGL16 regulates genome-wide gene expression and flowering time with partial dependency on SOC1 in Arabidopsis
Dong, X.; Zhang, L.-P.; Yu, D.; Cheng, F.; Dong, Y.; Jiang, X.; Qian, F.; Turck, F. K.; Hu, J.
10.1101/2021.05.10.443448 — plant biology — Posted on 2021-05-10
3207 Regulation of Src tumor activity by its N-terminal intrinsically disordered region
APONTE, E.; Lafitte, M.; Sirvent, A.; Simon, V.; barbery, M.; Fourgous, E.; Maffei, M.; Armand, F.; Hamelin, R.; Pannequin, J.; Fort, P. P.; Pons, M.; roche, s.
10.1101/2021.05.10.443360 — cancer biology — Posted on 2021-05-10
3208 Coordinated regulation of WNT/β-catenin, c-Met, and Integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits
Giacomelli, C.; Jung, J.; Wachter, A.; Ibing, S.; Will, R.; Mannsperger, H.; Uhlmann, S.; Sahin, O.; Yarden, Y.; Beissbarth, T.; Korf, U.; Körner, C.; Wiemann, S.
10.1101/2021.05.10.443372 — cancer biology — Posted on 2021-05-10
3210 Sex-Specific Function and Morphology of the Anterior Cruciate Ligament During Skeletal Growth in a Porcine Model
Howe, D.; Cone, S. G.; Piedrahita, J. A.; Collins, B.; Fordham, L. A.; Griffith, E. H.; Spang, J. T.; Fisher, M. B.
10.1101/2021.05.10.442986 — bioengineering — Posted on 2021-05-10
3212 Genome size evolution in the diverse insect order Trichoptera
Heckenhauer, J.; Frandsen, P. B.; Sproul, J. S.; Li, Z.; Paule, J.; Larracuente, A. M.; Maughan, P. J.; Barker, M. S.; Schneider, J. V.; Pauls, S. U.
10.1101/2021.05.10.443368 — evolutionary biology — Posted on 2021-05-10
3213 iPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome
Xu, X.; Jin, K.; Bais, A. S.; Zhu, W.; Yagi, H.; Feinstein, T. N.; Nguyen, P.; Criscione, J.; Liu, X.; Beutner, G.; Karunakaran, K. B.; Adams, P.; Kuo, C. K.; Kostka, D.; Pryhuber, G. S.; Shiva, S.; Ganapathiraju, M.; Porter, G. A.; Lin, J.-H. I.; Aronow, B. J.; Lo, C. W.
10.1101/2021.05.09.443165 — cell biology — Posted on 2021-05-10
3214 Diagnosis and analysis of unexplained cases of childhood encephalitis in Australia using metagenomic next-generation sequencing
Li, C.-X.; Burrell, R.; Dale, R. C.; Kesson, A.; Blyth, C. C.; Clark, J. E.; Crawford, N.; Jones, C. A.; Britton, P. N.; Holmes, E. C.
10.1101/2021.05.10.443367 — microbiology — Posted on 2021-05-10
3216 Vaccination-induced rapid protection against bacterial pneumonia via training alveolar macrophage in mice
Hao, G.; Zeng, X.; Peng, L.; Xiang, C.; Zhou, Y.; Zhang, X.; Zhang, J.; Wang, N.; Guo, G.; Li, Y.; Liu, K.; Gu, J.; Zeng, H.; Zhuang, Y.; Li, H.; Zhang, J.; Zhang, W.; Zou, Q.; Shi, Y.
10.1101/2021.05.10.443370 — immunology — Posted on 2021-05-10
3217 Neural correlates of individual differences in aversion to risk and choice inconsistencies
Jaquerod, M. E.; Lintas, A.; Gratton, G.; Fabiani, M.; Low, K. A.; Tobler, P. N.; Villa, A. E. P.
10.1101/2021.05.10.443362 — neuroscience — Posted on 2021-05-10
3219 Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers
Berhanu Lemma, R.; Fleischer, T.; Martinsen, E.; Kristensen, V. N.; Eskeland, R.; Gabrielsen, O. S.; Mathelier, A.
10.1101/2021.05.10.443359 — cancer biology — Posted on 2021-05-10
3222 Cell Surface Glycan Engineering Reveals that Matriglycan Alone can Recapitulate Dystroglycan Binding and Function
Sheikh, M. O.; Capicciotti, C. J.; Liu, L.; Praissman, J. L.; Mead, D. G.; Brindley, M. A.; Willer, T.; Campbell, K. P.; Moremen, K. W.; Wells, L.; Boons, G.-J.
10.1101/2021.05.10.443358 — biochemistry — Posted on 2021-05-10
3224 Comprehensive analysis of meiosis-derived cDNA libraries reveals gene isoforms and mitochondrial proteins important for competitive fitness
Sing, T. L.; Conlon, K.; Lu, S. H.; Madrazo, N.; Barker, J. C.; Hollerer, I.; Brar, G. A.; Sudmant, P. H.; Ünal, E.
10.1101/2021.05.10.443361 — genetics — Posted on 2021-05-10
3226 Live 3D imaging and mapping of shear stresses within tissues using incompressible elastic beads
SOUCHAUD, A.; BOUTILLON, A.; CHARRON, G.; ASNACIOS, A.; NOUS, C.; DAVID, N. B.; GRANER, F.; Gallet, F.
10.1101/2021.05.10.443363 — biophysics — Posted on 2021-05-10
3227 Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing.
Thapa, D.; de Sousa Valente, J.; Barrett, B.; Argunhan, F.; Lee, S. Y.; Nikitochkina, S.; Kodji, X.; Brain, S. D.
10.1101/2021.05.10.443379 — biochemistry — Posted on 2021-05-10
3228 Sugar units, not chilling units, control endodormancy duration in plants; potato tuber as a case study
Danieli, R.; Assouline, S.; Salam, B. B.; Teper-Bamnolker, P.; Belausov, E.; Friedmann, Y.; Granot, D.; Eshel, D.
10.1101/2021.05.10.443356 — plant biology — Posted on 2021-05-10
3231 The genetic architecture of phenotypic diversity in the betta fish (Betta splendens)
Zhang, W.; Wang, H.; Brandt, D. Y. C.; Hu, B.; Sheng, J.; Wang, M.; Luo, H.; Guo, S.; Sheng, B.; Zeng, Q.; Peng, K.; Zhao, D.; Jian, S.; Wu, D.; Wang, J.; van Esch, J. H. M.; Shi, W.; Ren, J.; Nielsen, R.; Hong, Y.
10.1101/2021.05.10.443352 — genetics — Posted on 2021-05-10
3236 TAP: Targeting and analysis pipeline for optimization and verification of TMS coil placement
Dannhauer, M.; Huang, Z.; Beynel, L.; Wood, E.; Bukhari-Parlakturk, N.; Peterchev, A. V.
10.1101/2021.05.09.443339 — neuroscience — Posted on 2021-05-10
3237 Minimal functional alignment of ventromedial prefrontal cortex intracranial EEG signals during naturalistic viewing
Xie, T.; Cheong, J. H.; Manning, J. R.; Brandt, A. M.; Aronson, J. P.; Jobst, B. C.; Bujarski, K. A.; Chang, L. J.
10.1101/2021.05.10.443308 — neuroscience — Posted on 2021-05-10
3238 Disrupted microglial iron homeostasis in progressive multiple sclerosis
Ofengeim, D.; Proto, J. D.; Zhang, M.; Ryan, S.; Yao, X.; Huang, Y.; Dufault, M.; Chomyk, A.; Chang, Y.-C.; Saleh, J.; Sancho, J.; Hammond, T.; Christie, E.
10.1101/2021.05.09.443127 — neuroscience — Posted on 2021-05-10
3240 Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma
Davidson, S. M.; Heyman, J. E.; O'Brien, J. P.; Liu, A. C.; Schmidt, D. R.; Israelsen, W. J.; Dayton, T. L.; Sehgal, R.; Bronson, R.; Freinkman, E.; Mak, H.; Malstrom, S.; Bellinger, G.; Carracedo, A.; Pandolfi, P. P.; Courtney, K. D.; Frangioni, J.; Jha, A.; DePinho, R. A.; Horner, J.; Thomas, C.; Cantley, L. C.; Loda, M.; Vander Heiden, M. G.
10.1101/2021.05.09.443334 — cancer biology — Posted on 2021-05-10
3241 Reciprocal impacts of telomerase activity and tumor cell differentiation in neuroblastoma tumor biology
Yu, E. Y.; Zahid, S. S.; Aloe, S.; Falck-Pedersen, E.; Zhou, X. K.; Cheung, N.-K.; Lue, N.
10.1101/2021.05.09.442765 — cancer biology — Posted on 2021-05-10
3243 Structural basis for ligand recognition and G protein-coupling promiscuity of the cholecystokinin A receptor
Liu, Q.; Yang, D.; Zhuang, Y.; Croll, T. I.; Cai, X.; Dai, A.; He, X.; Duan, J.; Yin, W.; Ye, C.; Zhou, F.; Wu, B.; Zhao, Q.; Xu, H. E.; Wang, M.-W.; Jiang, Y.
10.1101/2021.05.09.443337 — biophysics — Posted on 2021-05-10
3249 Distinct states of proinsulin misfolding in MIDY
Haataja, L.; Arunagiri, A.; Hassan, A.; Regan, K.; Tsai, B.; Dhayalan, B.; Weiss, M. A.; Liu, M.; Arvan, P.
10.1101/2021.05.10.442447 — biochemistry — Posted on 2021-05-10
3250 Resource Profile and User Guide of the Polygenic Index Repository
Becker, J.; Burik, C. A. P.; Goldman, G.; Wang, N.; Jayashankar, H.; Bennett, M.; Belsky, D. W.; Linner, R. K.; Ahlskog, R.; Kleinman, A.; Hinds, D. A.; 23andMe Research Group, ; Caspi, A.; Corcoran, D. L.; Moffitt, T. E.; Poulton, R.; Sugden, K.; Williams, B. S.; Harris, K. M.; Steptoe, A.; Ajnakina, O.; Milani, L.; Esko, T.; Iacono, W. G.; McGue, M.; Magnusson, P. K. E.; Mallard, T. T.; Harden, K. P.; Tucker-Drob, E. M.; Herd, P.; Freese, J.; Young, A.; Beauchamp, J. P.; Koellinger, P.; Oskarsson, S.; Johannesson, M.; Visscher, P. M.; Meyer, M. N.; Laibson, D.; Cesarini, D.; Benjamin, D. J.
10.1101/2021.05.08.443158 — genomics — Posted on 2021-05-10
3254 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes and normal tissues
Diamanti, K.; Cavalli, M.; Pereira, M. J.; Pan, G.; Castillejo-Lopez, C.; Kumar, C.; Mundt, F.; Komorowski, J.; Deshmukh, A. S.; Mann, M.; Korsgren, O.; Eriksson, J. W.; Wadelius, C.
10.1101/2021.05.09.443296 — cell biology — Posted on 2021-05-10
3259 Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 (NR4A2)
Kholodar, S. A.; Lang, G.; Cortopassi, W. A.; Iizuka, Y.; Brah, H. S.; Jacobson, M. P.; England, P. M.
10.1101/2021.05.09.442997 — neuroscience — Posted on 2021-05-10
3261 Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells.
Li, Q.; Feng, Y.; Xue, Y.; Zhan, X.; Fu, Y.; Gui, G.; Richard, J.-P.; Taga, A.; Mao, X.; Maragakis, N. J.; Ying, M.
10.1101/2021.05.09.443325 — neuroscience — Posted on 2021-05-10
3264 Morphometric relationships and their contribution to biomass and cannabinoid yield in hybrids of hemp (Cannabis sativa)
Carlson, C. H.; Stack, G. M.; Jiang, Y.; Taskiran, B.; Cala, A. R.; Toth, J. A.; Philippe, G.; Rose, J. K. C.; Smart, C. D.; Smart, L. B.
10.1101/2021.05.09.443329 — plant biology — Posted on 2021-05-10
3265 Permeability profiling of all 13 Arabidopsis PIP aquaporins using a high throughput yeast approach
Groszmann, M.; De Rosa, A.; Chen, W.; Qiu, J.; McGaughey, S.; Byrt, C. S.; Evans, J. R.
10.1101/2021.05.09.443061 — plant biology — Posted on 2021-05-10
3267 Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta
Jian, Y.; Kong, L.; Xu, H.; Huang, X.; Li, Y.; Shi, D.; Xiao, Y.; Yang, M.; Li, S.; Chen, X.; Ouyang, Y.; Hu, Y.; Chen, X.; Liu, P.; Wei, W.
10.1101/2021.05.09.443305 — cancer biology — Posted on 2021-05-10
3268 The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Polyanskaya, S. A.; Moreno, R. Y.; Lu, B.; Feng, R.; Yao, Y.; Irani, S.; Klingbeil, O.; Yang, Z.; Wei, Y.; Demerdash, O. E.; Benjamin, L. A.; Weiss, M. J.; Zhang, Y.; Vakoc, C. R.
10.1101/2021.05.09.443327 — cancer biology — Posted on 2021-05-10
3271 Ariadne: Barcoded Linked-Read Deconvolution Using de Bruijn Graphs
Mak, L.; Meleshko, D.; Danko, D. C.; Barakzai, W. N.; Belchikov, N.; Hajirasouliha, I.
10.1101/2021.05.09.443255 — genomics — Posted on 2021-05-10
3272 SCON - A Short Conditional intrON for conditional knockout with one-step zygote injection
Wu, S.-H. S.; Szep-Bakonyi, R.; Lee, H.; Colozza, G.; Boese, A.; Gert, K. R.; Hallay, N.; Kim, J.; Zhu, Y.; Pilat-Carotta, S.; Theussl, H.-C.; Pauli, A.; Koo, B.-K.
10.1101/2021.05.09.443220 — genetics — Posted on 2021-05-10
3274 Climate-change risk analysis for global urban forests
Esperon-Rodriguez, M.; Baumgartner, J. B.; Beaumont, L. J.; Lenoir, J.; Nipperess, D. A.; Power, S. A.; Richard, B.; Rymer, P. D.; Tjoelker, M. G.; Gallagher, R. V.
10.1101/2021.05.09.443030 — ecology — Posted on 2021-05-10
3276 Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling
McGlone, E. R.; Manchanda, Y.; Jones, B.; Pickford, P.; Inoue, A.; Carling, D.; Bloom, S. R.; Tan, T. M.; Tomas, A.
10.1101/2021.05.09.443291 — cell biology — Posted on 2021-05-10
3278 Hyperinflammation evokes different antiviral TMPRSS2 and ADAM17 expression responses in human gut xenograft versus host mouse gut although overall genomic responses are similar
Morris, L.; Nissim-Eliraz, E.; Schouten, I.; Bergey, F.; Dyer, N.; Momiji, H.; Nir, E.; Marsiano, N.; Tezerji, R. S.; Yagel, S.; Rosenstiel, P.; Rand, D. A.; Martins dos Santos, V. A. P.; Shpigel, N. Y.; SysmedIBD research consortium,
10.1101/2021.05.09.443289 — immunology — Posted on 2021-05-10
3279 Dichotomous thinking and informational waste in neuroimaging
Chen, G.; Taylor, P. A.; Stoddard, J.; Cox, R. W.; Bandettini, P. A.; Pessoa, L.
10.1101/2021.05.09.443246 — neuroscience — Posted on 2021-05-10
3282 Population Structure of Nation-wide Rice in Thailand
Vejchasarn, P.; Shearman, J. R.; Chaiprom, U.; Phansenee, Y.; Tulyananda, T.; Jairin, J.; Amornbunchornvej, C.
10.1101/2021.05.09.443284 — genetics — Posted on 2021-05-10
3283 Elucidating the diversity of microeukaryotes and epi-endophytes in the brown algal holobiome
Bjorbaekmo, M. F. M.; Brodie, J.; Logares, R.; Attwood, S.; Fredriksen, S.; Fuss, J.; Shalchian-Tabrizi, K.; Wold-Dobbe, A.; Krabberod, A. K.; Bass, D.
10.1101/2021.05.09.443287 — ecology — Posted on 2021-05-10
3284 Meiofauna is an important, yet neglected, component of biodiversity of Posidonia oceanica
Garcia-Gomez, G.; Garcia-Herrero, A.; Sanchez, N.; Pardos, F.; Izquierdo-Munoz, A.; Fontaneto, D.; Martinez, A.
10.1101/2021.05.09.443247 — ecology — Posted on 2021-05-10
3293 Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects
Jain, S.; Rick, J.; Joshi, R.; Beniwal, A.; Spatz, J.; Chang, A. C.-C.; Nguyen, A. T.; Sudhir, S.; Chandra, A.; Haddad, A.; Wadhwa, H.; Shah, S. S.; Choi, S.; Hayes, J. L.; Wang, L.; Yagnik, G.; Costello, J. F.; Diaz, A.; Aghi, M. K.
10.1101/2021.05.08.443250 — cancer biology — Posted on 2021-05-10
3294 The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases
Gorodetska, I.; Offermann, A.; Pueschel, J.; Lukiyanchuk, V.; Gaete, D.; Kurzyukova, A.; Labitzky, V.; Schwarz, F.; Lange, T.; Knopf, F.; Wielockx, B.; Krause, M.; Perner, S.; Dubrovska, A.
10.1101/2021.05.08.443223 — cancer biology — Posted on 2021-05-10
3296 metID: A R package for automatable compound annotation for LC-MS-based data
Shen, X.; Wu, S.; Liang, L.; Chen, S.; Contrepois, K.; Zhu, Z.-J.; Snyder, M.
10.1101/2021.05.08.443258 — bioinformatics — Posted on 2021-05-10
3303 In vivo imaging of cannabinoid type 2 receptors, functional and structural alterations in mouse model of cerebral ischemia by PET and MRI
Ni, R.; Muller Herde, A.; Haider, A.; Keller, C.; Louloudis, G.; Vaas, M.; Schibli, R.; Ametamey, S. M.; Klohs, J.; Mu, L.
10.1101/2021.05.08.441033 — neuroscience — Posted on 2021-05-10
3304 Dietary restriction and clock delay eye aging to extend lifespan in D. melanogaster
Hodge, B. A.; Meyerhof, G. T.; Katewa, S. D.; Lian, T.; Lau, C.; Bar, S.; Leung, N.; Li, M.; Li-Kroeger, D.; Melov, S.; Schilling, B.; Montell, C.; Kapahi, P.
10.1101/2021.05.08.443272 — neuroscience — Posted on 2021-05-10
3313 Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by slowing luminal transport
Konno, T.; Parutto, P.; Bailey, D. M. D.; Davi, V.; Crapart, C.; Awadelkareem, M. A.; Hockings, C.; Brown, A.; Xiang, K. M.; Agrawal, A.; Chambers, J. E.; Werp, M. V.; Koning, K.; Metzakopian, E.; Westrate, L.; Koslover, E.; Avezov, E.
10.1101/2021.05.10.441946 — cell biology — Posted on 2021-05-10
3314 The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties
Tattersall, L.; Shah, K. M.; Lath, D. L.; Singh, A.; Down, J. M.; De Marchi, E.; Williamson, A.; Di Virgilio, F.; Heymann, D.; Adinolfi, E.; Fraser, W. D.; Green, D.; Lawson, M. A.; Gartland, A.
10.1101/2021.05.07.443092 — cancer biology — Posted on 2021-05-10
3316 Transcriptomic Insights into the Responses in Leaves Storing Lipid Organelles under Different Irradiances
Winichayakul, S.; Macknight, R. C.; Beechey-Gradwell, Z.; Lee, R.; Xue, H.; Crowther, T.; Anderson, P.; Richardson, K.; Zou, X.; Maher, D.; Brock, S.; Cooney, L.; Bryan, G.; Roberts, N. J.
10.1101/2021.05.09.443314 — molecular biology — Posted on 2021-05-10
3318 Predicting lineage-specific differences in open chromatin across dozens of mammalian genomes
Kaplow, I. M.; Schaffer, D. E.; Wirthlin, M. E.; Lawler, A. J.; Brown, A. R.; Kleyman, M.; Pfenning, A. R.
10.1101/2020.12.04.410795 — genetics — Posted on 2021-05-10
3325 Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator
Jahn, M.; Crang, N.; Janasch, M.; Hober, A.; Forsström, B.; Kimler, K.; Mattausch, A.; Chen, Q.; Asplund-Samuelsson, J.; Hudson, E. P.
10.1101/2021.03.21.436304 — systems biology — Posted on 2021-05-10
3331 χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain
Shin, H.-G.; Lee, J.; Yun, Y. H.; Yoo, S. H.; Jang, J.; Oh, S.-H.; Nam, Y.; Jung, S.; Kim, S.; Fukunaga, M.; Kim, W.; Choi, H. J.; Lee, J.
10.1101/2020.11.07.363796 — neuroscience — Posted on 2021-05-09
3332 Minimal phrase composition revealed by intracranial recordings
Murphy, E.; Woolnough, O.; Rollo, P. S.; Roccaforte, Z. J.; Segaert, K.; Hagoort, P.; Tandon, N.
10.1101/2021.04.30.442171 — neuroscience — Posted on 2021-05-09
3333 White matter microstructure characterisation in temporal lobe epilepsy
Rolandi, N.; Palesi, F.; Padelli, F.; Giachetti, I.; Aquino, D.; Summers, P.; Tartara, E.; Germani, G.; Mariani, V.; D'Angelo, E.; Tassi, L.; Gandini Wheeler-Kingshott, C. A.; Vitali, P.
10.1101/2021.05.08.442908 — neuroscience — Posted on 2021-05-09
3337 Increasing phagocytosis of microglia through targeting CD33 with liposomes displaying glycan ligands
Bhattacherjee, A.; Daskhan, G.; Bains, A.; Watson, A. E. S.; Eskandari-Sedighi, G.; St. Laurent, C. D.; Voronova, A.; Macauley, M. S.
10.1101/2021.05.08.443135 — immunology — Posted on 2021-05-09
3338 ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data
Waller, L.; Erk, S.; Pozzi, E.; Toenders, Y. J.; Haswell, C. C.; Büttner, M.; Thompson, P. M.; Schmaal, L.; Morey, R. A.; Walter, H.; Veer, I. M.
10.1101/2021.05.07.442790 — neuroscience — Posted on 2021-05-09
3341 HIPPOCAMPAL DNA METHYLATION, DNAm AGE AND SPATIAL MEMORY PERFORMANCE IN YOUNG AND OLD RATS
Chiavellini, P.; Lehmann, M.; Canatelli-Mallat, M.; Zoller, J. A.; Herenu, C. B.; Morel, G. R.; Horvath, S.; Goya, R. G.
10.1101/2021.05.07.443204 — neuroscience — Posted on 2021-05-09
3343 Bayesian Additive Regression Trees for Genotype by Environment Interaction Models - AMBARTI
Sarti, D. A.; Prado, E. B.; Inglis, A.; dos Santos, A. A. L.; Hurley, C.; Moral, R. d. A.; Parnell, A.
10.1101/2021.05.07.442731 — bioinformatics — Posted on 2021-05-09
3344 Comparing host module activation patterns and temporal dynamics in infection by influenza H1N1 viruses
Nudelman, I.; Kudrin, D.; Nudelman, G.; Deshpande, R.; Hartmann, B. M.; Kleinstein, S. H.; Myers, C. L.; Sealfon, S. C.; Zaslavsky, E.
10.1101/2021.05.07.443162 — bioinformatics — Posted on 2021-05-09
3346 Embeddings of genomic region sets capture rich biological associations in lower dimensions
Gharavi, E.; Gu, A.; Zheng, G.; Smith, J. P.; Zhang, A.; Brown, D. E.; Sheffield, N. C.
10.1101/2021.05.07.443166 — bioinformatics — Posted on 2021-05-09
3353 Defining 'Destructive fishing': a lack of consensus inhibits effective global policy
Willer, D. F.; Brian, J. I.; Derrick, C.; Walker, J.; Benbow, S.; Brooks, H.; Hazin, C.; McCarthy, A. H.; Mukherjee, N.; McOwen, C.; Steadman, D.
10.1101/2021.05.07.443117 — ecology — Posted on 2021-05-09
3354 Ecosystem photosynthesis in land-surface models: a first-principles approach
Mengoli, G.; Agusti-Panareda, A.; Boussetta, S.; Harrison, S. P.; Trotta, C.; Prentice, I. C.
10.1101/2021.05.07.442894 — ecology — Posted on 2021-05-09
3358 Stress-induced protein disaggregation in the Endoplasmic Reticulum catalysed by BiP
Pinho Melo, E.; Farace, I.; Konno, T.; Ali Awadelkareem, M.; Skov, L. R.; Sancho, T. P.; Paton, A. W.; Paton, J. C.; Fares, M.; M. R. Paulo, P.; Zhang, X.; Avezov, E.
10.1101/2021.05.09.442953 — molecular biology — Posted on 2021-05-09
3359 SARS-CoV-2 B.1.617 emergence and sensitivity to vaccine-elicited antibodies
Ferreira, I.; Datir, R.; Papa, G.; Kemp, S.; Meng, B.; Rakshit, P.; Singh, S.; Pandey, R.; Ponnusamy, K.; Radhakrishnan, V. S.; INSACOG CONSORTIUM, ; COG-UK CONSORTIUM, ; Sato, K.; James, L.; Aggarwal, A.; Gupta, R. K.
10.1101/2021.05.08.443253 — microbiology — Posted on 2021-05-09
3360 Vaccination boosts naturally enhanced neutralizing breadth to SARS-CoV-2 one year after infection
Wang, Z.; Muecksch, F.; Schaefer-Babajew, D.; Finkin, S.; Viant, C.; Gaebler, C.; Barnes, C. O.; Cipolla, M.; Ramos, V.; Oliveira, T. Y.; Cho, A.; Schmidt, F.; Silva, J. D.; Bednarski, E.; Daga, M.; Turroja, M.; Millard, K. G.; Jankovic, M.; Gazumyan, A.; Bieniasz, P. D.; Caskey, M.; Hatziioannou, T.; Nussenzweig, M. C.
10.1101/2021.05.07.443175 — immunology — Posted on 2021-05-09
3361 In-vivo Protection from SARS-CoV-2 infection by ATN-161 in k18-hACE2 transgenic mice
Narayanappa, A.; Engler-Chiurazzi, E. B.; Murray-Brown, I. C.; Gressett, T. E.; Biose, I. J.; Chastain, W. H.; Bix, G.
10.1101/2021.05.08.443275 — immunology — Posted on 2021-05-09
3362 Expansion of tissue-resident CD8+ T cells and CD4+ Th17 cells in the nasal mucosa following mRNA COVID-19 vaccination
Ssemaganda, A.; Nguyen, H. M.; Nuhu, F.; Jahan, N.; Card, C. M.; Kiazyk, S.; Severini, G.; Keynan, Y.; Su, R.-C.; Ji, H.; Abrenica, B.; McLaren, P. J.; Ball, B.; Bullard, J.; Van Caeseele, P.; Stein, D.; McKinnon, L.
10.1101/2021.05.07.442971 — immunology — Posted on 2021-05-09
3364 Inhibition-Dominated Rich-Club Shapes Dynamics in Cortical Microcircuits of Awake Behaving Mice
Hafizi, H.; Nigam, S.; Barnathan, J.; Stevenson, I.; Masmanidis, S. C.; Newman, E. L.; Sporns, O.; Beggs, J.
10.1101/2021.05.07.443074 — neuroscience — Posted on 2021-05-09
3365 Short Association Fibre Tractography
Shastin, D.; Genc, S.; Parker, G. D.; Koller, K.; Tax, C. M. W.; Evans, J.; Hamandi, K.; Gray, W. P.; Jones, D. K.; Chamberland, M.
10.1101/2021.05.07.443084 — neuroscience — Posted on 2021-05-09
3369 RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2
Li, P. P.; Moulick, R.; Feng, H.; Sun, X.; Arbez, N.; Jin, J.; Marque, L. O.; Hedglen, E.; Chan, H. Y. E.; Ross, C. A.; Pulst, S. M.; Margolis, R. L.; Woodson, S.; Rudnicki, D. D.
10.1101/2021.05.07.443200 — neuroscience — Posted on 2021-05-09
3370 Benchmarking 50 classification algorithms on 50 gene-expression datasets
Piccolo, S. R.; Mecham, A.; Golightly, N. P.; Johnson, J. L.; Miller, D. B.
10.1101/2021.05.07.442940 — bioinformatics — Posted on 2021-05-09
3372 Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation
Bracho-Sanchez, E.; Rocha, F.; Bedingfield, S. K.; Partain, B. D.; Brusko, M. A.; Colazo, J. M.; Fettis, M. M.; Farhadi, S. A.; Helm, E. Y.; Koenders, K.; Kwiatkowski, A. J.; Macias, S. L.; Restuccia, A.; Wanchoo, A.; Avram, D.; Allen, K. D.; Duvall, C. L.; Wallet, S. M.; Hudalla, G. A.; Keselowsky, B. G.
10.1101/2021.05.07.443161 — bioengineering — Posted on 2021-05-09
3378 Neutrophils impose strong selective pressure against PfEMP1 variants implicated in cerebral malaria
Zelter, T.; Strahilevitz, J.; Simantov, K.; Yajuk, O.; Jensen, A.; Dzikowski, R.; Granot, Z.
10.1101/2021.05.09.443317 — microbiology — Posted on 2021-05-09
3380 An intranasal vaccine durably protects against SARS-CoV-2 variants in mice
Hassan, A. O.; Shrihari, S.; Gorman, M. J.; Ying, B.; Yuan, D.; Raju, S.; Chen, R. E.; Dmitriev, I. P.; Kashentseva, E.; Adams, L. J.; Shi, P.-Y.; Fremont, D. H.; Curiel, D. T.; Alter, G.; Diamond, M. S.
10.1101/2021.05.08.443267 — microbiology — Posted on 2021-05-09
3386 Oligomannosylation and MAN1A1 expression associate strongly with a subset of human cancer types
Chatterjee, S.; Kawahara, R.; Ugonotti, J.; Lee, L. Y.; Everest-Dass, A.; Thaysen-Andersen, M.
10.1101/2021.05.08.443254 — biochemistry — Posted on 2021-05-09
3387 A new role of low barrier hydrogen bond in mediating protein stability by small molecules
Yang, J.; Li, Y.; Qiu, Q.; Wang, R.; Yan, W.; Yu, Y.; Niu, L.; Pei, H.; Wei, H.; Ouyang, L.; Ye, H.; Xu, D.; Wei, Y.; Chen, Q.; Chen, L.
10.1101/2021.05.09.443293 — biochemistry — Posted on 2021-05-09
3388 The Core Human Fecal Metabolome
Haffner, J.; Katemauswa, M.; Kagone, T. S.; Hossain, E.; Jacobson, D.; Flores, K.; Parab, A. R.; Obregon-Tito, A. J.; Tito, R. Y.; Marin Reyes, L.; Troncoso-Corzo, L.; Guija-Poma, E.; Meda, N.; Carabin, H.; Honap, T. P.; Sankaranarayanan, K.; Lewis, C. M.; McCall, L.-I.
10.1101/2021.05.08.442269 — biochemistry — Posted on 2021-05-09
3390 The K18-hACE2 Transgenic Mouse Model Recapitulates Non-Severe and Severe COVID-19 in Response to Infectious Dose of SARS-CoV-2 Virus
Yu, J.; Dong, W.; Li, A.; Zhang, J.; Caligiuri, M.; Jaramillo, S.; Mead, H. L.; Stone, N. E.; Jones, A.; Kollath, D. R.; Coyne, V. K.; Yearsley, M.; Wang, L.-S.; Barker, B. M.; Keim, P.; Barr, T.
10.1101/2021.05.08.443244 — microbiology — Posted on 2021-05-09
3391 Suppression of Global Protein Translation in SARS-CoV-2 Infection
Parthasarathy, H.; Gupta, D.; Suresh, A. P.; Tandel, D.; Sah, V.; Harshan, K. H.
10.1101/2021.05.08.443207 — microbiology — Posted on 2021-05-09
3394 Antibody ligation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans
Klaile, E.; Prada Salcedo, J. P.; Klassert, T. E.; Besemer, M.; Bothe, A.-K.; Durotin, A.; Mueller, M. M.; Schmitt, V.; Luther, C. H.; Dittrich, M.; Singer, B. B.; Dandekar, T.; Slevogt, H.
10.1101/2021.02.11.430790 — immunology — Posted on 2021-05-09
3395 Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Ahearn, T. U.; Zhang, H.; Michailidou, K.; Milne, R. L.; Bolla, M. K.; Dennis, J.; Dunning, A. M.; Lush, M.; Wang, Q.; Andrulis, I. L.; Anton-Culver, H.; Arndt, V.; Aronson, K. J.; Auer, P. L.; Augustinsson, A.; Baten, A.; Becher, H.; Behrens, S.; Benitez, J.; Bermisheva, M.; Blomqvist, C.; Bojesen, S. E.; Bonanni, B.; Borresen-Dale, A.-L.; Brauch, H.; Brenner, H.; Brooks-Wilson, A.; Bruning, T.; Burwinkel, B.; Canzian, F.; Castelao, J. E.; Chang-Claude, J.; Chanock, S.; Chenevix-Trench, G.; Clarke, C. L.; NBCS Collaborators, ; Collee, J. M.; Cox, A.; Cross, S. S.; Czene, K.; Daly, M. B.; Dev
10.1101/733402 — genetics — Posted on 2021-05-09
3398 Massive export of diazotrophs across the tropical south Pacific Ocean
Bonnet, S.; Benavides, M.; Camps, M.; Torremocha, A.; Grosso, O.; Spungin, D.; Berman-Frank, I.; Le Moigne, F. A. C.
10.1101/2021.05.07.442706 — microbiology — Posted on 2021-05-09
3399 Identification of candidate genes for self-compatibility in perennial ryegrass (Lolium perenne L.)
Cropano, C.; Manzanares, C.; Yates, S.; Copetti, D.; Do Canto, J.; Lübberstedt, T.; Koch, M.; Studer, B.
10.1101/2021.03.29.437398 — plant biology — Posted on 2021-05-09
3402 Dynamic behavioral and molecular changes induced by chronic stress exposure in mice
Prevot, T. D.; Chatterjee, D.; Knoch, J.; Codeluppi, S.; Misquitta, K. A.; Fee, C.; Newton, D.; Oh, H.; Sibille, E.; Banasr, M.
10.1101/2021.05.07.443011 — neuroscience — Posted on 2021-05-08
3404 The evolution of regulatory elements in the emerging promoter variant strains of HIV-1
Bhange, D.; Prasad, N.; Singh, S.; Prajapati, H. K.; Maurya, S. P.; Gopalan, B. P.; Nadig, S.; Chaturbhuj, D.; Boobalan, J.; Dinesha, T. R.; Ahamed, S. F.; Singh, N.; Brahmaiah, A.; Mehta, K.; Gohil, Y.; Balakrishnan, P.; Das, B. K.; Dias, M.; Gangakhedkar, R.; Mehendale, S.; Paranjape, R.; Saravanan, S.; Shet, A.; Solomon, S. S.; Thakar, M.; Ranga, U.
10.1101/2021.04.28.441760 — microbiology — Posted on 2021-05-08
3406 Increasing Grain Yield in Bread Wheat by Selection for High Spike Fertility Index
Pontaroli, A. C.; Alonso, M. P.; Mirabella, N. E.; Panelo, J. S.; Franco, M. F.; Vanzetti, L. S.; Lorenzo, M.
10.1101/2020.10.30.361782 — plant biology — Posted on 2021-05-08
3409 ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer
Trincado, J. L.; Reixachs-Sole, M.; Perez-Granado, J.; Fugmann, T.; Yokota, J.; Sanz, F.; Eyras, E.
10.1101/2020.06.18.159244 — bioinformatics — Posted on 2021-05-08
3412 Breathing on Chip: Biomechanical forces change airway epithelial cell biology ina human Airway Lung-Chip
Nawroth, J. C.; Roth, D.; van Schadewijk, A.; Ravi, A.; Maulana, T. I.; Senger, C. N.; van Riet, S.; Ninaber, D. K.; Ryan, A. L.; Hiemstra, P. S.; van der Does, A. M.
10.1101/2021.05.07.443164 — cell biology — Posted on 2021-05-08
3414 Mice learn multi-step routes by memorizing subgoal locations
Shamash, P.; Olesen, S. F.; Iordanidou, P.; Campagner, D.; Banerjee, N.; Branco, T.
10.1101/2020.08.19.256867 — neuroscience — Posted on 2021-05-08
3415 Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability and resistance to fibrinolysis
McPherson, H.; Duval, C.; Baker, S. R.; Hindle, M. S.; Cheah, L. T.; Asquith, N. L.; Domingues, M. M.; Ridger, V. C.; Connell, S. D. A.; Naseem, K.; Philippou, H.; Ajjan, R. A.; Ariens, R.
10.1101/2021.05.07.443174 — physiology — Posted on 2021-05-08
3417 Harnessing genetic diversity in the USDA pea (Pisum sativum L.) germplasm collection through genomic prediction
Bari, M. A. A.; Zheng, P.; Viera, I.; Worral, H.; Szwiec, S.; Ma, Y.; Main, D.; Coyne, C. J.; McGee, R.; Bandillo, N.
10.1101/2021.05.07.443173 — genomics — Posted on 2021-05-08
3419 Failure to detect mutations U2AF1 due to changes in the GRCh38 reference sequence
Miller, C. A.; Walker, J. R.; Jensen, T. L.; Hooper, W. F.; Fulton, R. S.; Painter, J. S.; Sekeres, M. A.; Ley, T. J.; Spencer, D. H.; Goll, J. B.; Walter, M. J.
10.1101/2021.05.07.442430 — genomics — Posted on 2021-05-08
3421 Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs
Burton, N.; Willis, A. R.; Fisher, K.; Braukmann, F.; Price, J.; Stevens, L.; Baugh, R.; Reinke, A. W.; Miska, E. A.
10.1101/2021.05.07.443118 — genetics — Posted on 2021-05-08
3423 Male differentiation in the marine copepod Oithona nana reveals the development of a new nervous ganglion linked to Lin12-Notch-Repeat protein-associated proteolysis
Sugier, K.; Laso-Jadart, R.; Vacherie, B.; Kafer, J.; Bertrand, L.; Labadie, K.; Martins, N.; Orvain, C.; Petit, E.; Poulain, J.; Wincker, P.; Jamet, J.-L.; Alberti, A.; Madoui, M.-A.
10.1101/2021.05.07.443100 — molecular biology — Posted on 2021-05-08
3424 Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor
Fields, J. K.; Kihn, K.; Birkedal, G. S.; Klontz, E. H.; Sjöström, K.; Günther, S.; Beadenkopf, R.; Forsberg, G.; Liberg, D.; Snyder, G. A.; Deredge, D.; Sundberg, E. J.
10.1101/2021.05.07.443154 — immunology — Posted on 2021-05-08
3425 ARS2-directed alternative splicing mediates CD28 driven T cell glycolysis and effector function
Holling, G. A.; Sharda, A. P.; Honikel, M. M.; James, C. M.; Lightman, S. M.; Qiao, G.; Singel, K. L.; Emmons, T. R.; Giridharan, T.; Hou, S.; Intlekofer, A. M.; Higashi, R. M.; Fan, T. W. M.; Lane, A. N.; Eng, K. H.; Segal, B. H.; Repasky, E. A.; Lee, K. P.; Olejniczak, S. H.
10.1101/2021.05.07.442963 — immunology — Posted on 2021-05-08
3428 The MAP4K4-STRIPAK complex promotes growth and tissue invasion in medulloblastoma
Migliavacca, J.; Zuellig, B.; Capdeville, C.; Grotzer, M. A.; Baumgartner, M.
10.1101/2021.05.07.442906 — cancer biology — Posted on 2021-05-08
3432 The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex
Vargas, R.; Freschi, L.; Spitaleri, A.; Tahseen, S.; Barilar, I.; Niemann, S.; Miotto, P.; Cirillo, D. M.; Köser, C. U.; Farhat, M. R.
10.1101/2021.05.07.443178 — genomics — Posted on 2021-05-08
3434 Standardized nuclear markers advance metazoan taxonomy
Dietz, L.; Eberle, J.; Mayer, C.; Kukowka, S.; Bohacz, C.; Baur, H.; Espeland, M.; Huber, B.; Hutter, C. R.; Mengual, X.; Peters, R.; Vences, M.; Wesener, T.; Willmott, K.; Misof, B.; Niehuis, O.; Ahrens, D.
10.1101/2021.05.07.443120 — molecular biology — Posted on 2021-05-08
3435 Mutation-specific reporter for the optimization and enrichment of prime editing
Schene, I. F.; Joore, I. P.; Baijens, J. H. L.; Shehata, S.; Ilcken, E. F.; Bolhuis, D. P.; van Rees, R. C. M.; Spelier, S. A.; van der Doef, H. P. J.; Beekman, J. M.; Nieuwenhuis, E. E. S.; Fuchs, S. A.
10.1101/2021.05.08.443062 — molecular biology — Posted on 2021-05-08
3437 Integrated Genome and Transcriptome Analyses Reveal the Mechanism of Genome Instability in Ataxia with Oculomotor Apraxia 2
Kanagaraj, R.; Mitter, R.; Kantidakis, T.; Edwards, M.; Benitez, A.; Chakravarty, P.; Fu, B.; Becherel, O.; Yang, F.; Lavin, M.; Koren, A.; Stewart, A.; West, S.
10.1101/2021.05.07.443085 — molecular biology — Posted on 2021-05-08
3440 Vesicle-bound regulatory RNAs are associated with tissue aging
Kern, F.; Kuhn, T.; Ludwig, N.; Simon, M.; Groeger, L.; Fabis, N.; Salhab, A.; Fehlmann, T.; Hahn, O.; Engel, A.; Koch, M.; Koehler, J.; Winek, K.; Soreq, H.; Fuhrmann, G.; Wyss-Coray, T.; Meese, E.; Laschke, M. W.; Keller, A.
10.1101/2021.05.07.443093 — molecular biology — Posted on 2021-05-08
3441 Molecular epidemiology of peste des petits ruminants virus emergence in critically endangered Mongolian saiga antelope and other wild ungulates
Benfield, C. T. O.; Hill, S.; Shatar, M.; Shiilegdamba, E.; Damdinjav, B.; Fine, A.; Willett, B.; Kock, R.; Bataille, A.
10.1101/2021.05.08.443216 — microbiology — Posted on 2021-05-08
3442 Diverse DNA modification in marine prokaryotic and viral communities
Hiraoka, S.; Sumida, T.; Hirai, M.; Toyoda, A.; Kawagucci, S.; Yokokawa, T.; Nunoura, T.
10.1101/2021.05.08.442635 — microbiology — Posted on 2021-05-08
3445 TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy
Mao, F.; Robinson, J.; Unger, T.; Posavi, M.; Amado, D.; Elman, L.; Grossman, M.; Wolk, D.; Lee, E.; Van Deerlin, V. M.; Porta, S.; Lee, V.; Trojanowski, J.; Chen-Plotkin, A. S.
10.1101/2021.05.07.442949 — neuroscience — Posted on 2021-05-08
3448 Combinatorial immunotherapies overcome MYC-driven immune evasion
Lee, J. V.; Houseley, F.; Yau, C.; Van de Mark, D.; Nakagawa, R.; Hemmati, G.; Hernandez, G. A.; Winkler, J.; Zhang, Y.; Samson, S.; Baas, C.; Esserman, L. J.; Van't Veer, L. J.; Rugo, H. S.; Matloubian, M.; Goga, A.
10.1101/2021.05.07.442684 — cancer biology — Posted on 2021-05-08
3450 Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly
Ahmed, J.; Fitch, T. C.; Donnelly, C. M.; Joseph, J. A.; Bassil, M. M.; Son, A.; Zhang, C.; Ledreux, A.; Horowitz, S.; Qin, Y.; Paredes, D.; Kumar, S.
10.1101/2021.05.08.443146 — biochemistry — Posted on 2021-05-08
3452 De novo activated transcription of insertd foreign coding sequences is inheritable in the plant genome
Hata, T.; Takada, N.; Hayakawa, C.; Kazama, M.; Uchikoba, T.; Tachikawa, M.; Matsuo, M.; Satoh, S.; Obokata, J.
10.1101/2020.11.28.402032 — evolutionary biology — Posted on 2021-05-08
3456 Minimal phrase composition revealed by intracranial recordings
Murphy, E.; Woolnough, O.; Rollo, P. S.; Roccaforte, Z. J.; Segaert, K.; Hagoort, P.; Tandon, N.
10.1101/2021.04.30.442171 — neuroscience — Posted on 2021-05-08
3461 Cas9-mediated gene disruption in tetraploid Giardia intestinalis
Horackova, V.; Voleman, L.; Hagen, K. D.; Petru, M.; Vinopalova, M.; Weisz, F.; Janowicz, N.; Markova, L.; Motyckova, A.; Tumova, P.; Dawson, S. C.; Dolezal, P.
10.1101/2021.04.21.440745 — cell biology — Posted on 2021-05-08
3462 Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration
Zisis, T.; Brückner, D. B.; Brandstätter, T.; d'Alessandro, J.; Vollmar, A. M.; Broedersz, C. P.; Zahler, S.
10.1101/2021.05.07.442718 — biophysics — Posted on 2021-05-08
3464 Hydration layer of only few molecules controls lipid mobility in biomimetic membranes
Chattopadhyay, M.; Krok, E.; Orlikowska, H.; Schwille, P.; Franquelim, H. G.; Piatkowski, L.
10.1101/2021.05.07.443086 — biophysics — Posted on 2021-05-08
3466 Limited reciprocal surrogacy of bird and habitat diversity and inconsistencies in their representation in Romanian protected areas
Geue, J.; Rotter, P. J.; Gross, C.; Benko, Z.; Kovacs, I.; Fantana, C.; Veres-Szaszka, J.; Dom?a, C.; Baltag, E.; Daroczi, S. J.; Bone, G. M.; Popescu, V. D.; Thomassen, H. A.
10.1101/2021.05.07.443068 — ecology — Posted on 2021-05-08
3468 Breathing on Chip: Biomechanical forces change airway epithelial cell biology ina human Airway Lung-Chip
Nawroth, J. C.; Roth, D.; van Schadewijk, A.; Ravi, A.; Maulana, T. I.; Senger, C. N.; van Riet, S.; Ninaber, D. K.; Ryan, A. L.; Hiemstra, P. S.; van der Does, A. M.
10.1101/2021.05.07.443164 — cell biology — Posted on 2021-05-08
3469 Improved methods for protein and single-molecule RNA detection in C. elegans embryos
Parker, D. M.; Winkenbach, L. P.; Parker, A.; Boyson, S.; Osborne Nishimura, E.
10.1101/2021.05.07.443170 — cell biology — Posted on 2021-05-08
3470 Consequences of PDGFRα+ fibroblast reduction in adult murine hearts
Kuwabara, J. T.; Bhutada, S.; Shettigar, V.; Gojanovich, G. S.; DeAngelo, L. P.; Heckl, J. R.; Johansooz, J. R.; Tacdol, D. K.; Ziolo, M. T.; Apte, S. S.; Tallquist, M. D.
10.1101/2021.05.07.443103 — cell biology — Posted on 2021-05-08
3471 Insulin mRNA is stored in RNA granules in resting beta cells
Vasiljevic, J.; Vasiljevic, D.; Ganss, K.; Sönmez, A.; Wegbrod, C.; Quezada, E.; Münster, C.; Schöniger, E.; Friedland, D.; Kipke, N.; Distler, M.; Selbach, M.; Solimena, M.
10.1101/2021.05.07.443159 — cell biology — Posted on 2021-05-08
3477 Reprogrammed iBlastoids contain amnion-like cells but not trophectoderm
Zhao, C.; Plaza Reyes, A.; Schell, J. P.; Weltner, J.; Ortega, N.; Zheng, Y.; Bjorklund, A. K.; Rossant, J.; Fu, J.; Petropoulos, S.; Lanner, F.
10.1101/2021.05.07.442980 — developmental biology — Posted on 2021-05-07
3481 Genomic surveillance of vancomycin-resistant Enterococcus faecium reveals spread of a linear plasmid conferring a nutrient utilization advantage
Boumasmoud, M.; Dengler Haunreiter, V.; Schweizer, T. A.; Meyer, L.; Chakrakodi, B.; Schreiber, P. W.; Seidl, K.; Kühnert, D.; Kouyos, R. D.; Zinkernagel, A. S.
10.1101/2021.05.07.442932 — microbiology — Posted on 2021-05-08
3483 Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion
You, R.; Artichoker, J.; Fries, A.; Edwards, A.; Combes, A. J.; Reeder, G.; Samad, B.; Krummel, M. F.
10.1101/2021.05.06.443033 — immunology — Posted on 2021-05-07
3487 A Mean Shift Algorithm for Drift Correction in Localization Microscopy
Fazekas, F. J.; Shaw, T. R.; Kim, S.; Bogucki, R. A.; Veatch, S. L.
10.1101/2021.05.07.443176 — biophysics — Posted on 2021-05-07
3488 Influenza A M2 Channel Oligomerization is Sensitive to its Chemical Environment
Townsend, J. A.; Sanders, H. M.; Rolland, A. D.; Prell, J. S.; Wang, J.; Marty, M. T.
10.1101/2021.05.07.443160 — biophysics — Posted on 2021-05-07
3490 Symmetry breaking in the female germline cyst
Nashchekin, D.; Busby, L.; Jacobs, M.; Squires, I.; St Johnston, D.
10.1101/2021.05.07.443143 — developmental biology — Posted on 2021-05-07
3491 The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms
Zhang, Y.; Hutterer, E.; Hultin, S.; Bergman, O.; Forteza, M. J.; Andonovic, Z.; Ketelhuth, D. F. J.; Roy, J.; Eriksson, P.; Holmgren, L.
10.1101/2021.05.07.443138 — cell biology — Posted on 2021-05-07
3492 ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
Teng, Y.-C.; Sundaresan, A.; O'Hara, R.; Gant, V. U.; Li, M.; Martire, S.; Warshaw, J. N.; Basu, A.; Banaszynski, L.
10.1101/2021.05.07.443199 — molecular biology — Posted on 2021-05-07
3494 Genetic Engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete
Romeis, E.; Tantalo, L.; Lieberman, N.; Phung, Q.; Greninger, A.; Giacani, L.
10.1101/2021.05.07.443079 — microbiology — Posted on 2021-05-07
3495 Panacea: a hyperpromiscuous antitoxin protein domain for the neutralisation of diverse toxin domains
Kurata, T.; Saha, C. K.; Buttress, J. A.; Mets, T.; Brodiazhenko, T.; Turnbull, K. J.; Awoyomi, O. F.; Oliveira, S. R. A.; Jimmy, S.; Ernits, K.; Delannoy, M.; Persson, K.; Tenson, T.; Strahl, H.; Hauryliuk, V.; Atkinson, G. C.
10.1101/2021.05.07.442387 — microbiology — Posted on 2021-05-07
3496 Effects of Platycodon grandiflorum on Gut Microbiota and Immune System of Immunosuppressed Mouse
Jhang, S. Y. Y.; Lee, S.-H.; Lee, E.-B.; Choi, J.-H.; Bang, S.; Jeong, M.; Jang, H.-H.; Kim, H.-J.; Lee, H.-J.; Jeong, H. C.; Lee, S. J.
10.1101/2021.05.07.443070 — microbiology — Posted on 2021-05-07
3497 Notch-Induced Endoplasmic Reticulum-Associated Degradation Governs Thymocyte β-Selection
Chen, X.; Liu, X.; Yu, J.; Xu, L.; Umphred-Wilson, K.; Peng, F.; Ding, Y.; Barton, B. M.; Lv, X.; Zhao, M. Y.; Sun, S.; Hong, Y.; Qi, L.; Adoro, S.
10.1101/2021.05.06.443041 — immunology — Posted on 2021-05-07
3498 Deciphering the role of mucosal immune responses and cervicovaginal microbiome in resistance to HIV infection in HIV-exposed seronegative (HESN) women
Munusamy Ponnan, S.; Thiruvengadam, K.; Tellapragada, C.; T Ambikan, A.; Narayanan, A.; Kathirvel, S.; Shankar, J.; Rajaraman, A.; Afsan Amanulla, M.; Thongadi Ramesh, D.; Selvamuthu, P.; Shanmugam, S.; Kailapuri Gangatharan, M.; Swaminathan, S.; Velu, V.; Barbara L, S.; Neogi, U.; Hanna, L. E.
10.1101/2021.05.07.443078 — immunology — Posted on 2021-05-07
3499 Frequent development of broadly neutralizing antibodies in early life in a large cohort of HIV-infected children
Fouda, G. G.; Lucier, A.; Fong, Y.; Li, S. H.; Dennis, M.; Eudailey, J.; Nelson, A.; Saunders, K.; Cunningham, C. K.; McFarland, E.; McKinney, R.; Moody, M. A.; LaBranche, C.; Montefiori, D.; Permar, S. R.
10.1101/2021.05.07.443081 — immunology — Posted on 2021-05-07
3500 Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV Associated Neurocognitive Disorders
Finkelstein, A.; Faiyaz, A.; Weber, M. T.; Qiu, X.; Uddin, M. N.; Zhong, J.; Schifitto, G.
10.1101/2021.05.06.443022 — neuroscience — Posted on 2021-05-07
3502 Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy
Comba, A.; Motsch, S.; Dunn, P. J.; Hollon, T. C.; Argento, A. E.; Zamler, D. B.; Kish, P. E.; Kahana, A.; Kleer, C. G.; Castro, M. G.; Lowenstein, P. R.
10.1101/2020.12.01.404970 — cancer biology — Posted on 2021-05-07
3504 Crop loss identification at field parcel scale using satellite remote sensing and machine learning
Hiremath, S.; Wittke, S.; Palosuo, T.; Kaivosoja, J.; Tao, F.; Proll, M.; Puttonen, E.; Peltonen-Sainio, P.; Marttinen, P.; Mamitsuka, H.
10.1101/2021.05.07.443072 — bioinformatics — Posted on 2021-05-07
3507 A bioorthogonal chemical reporter for fatty acid synthase-dependent protein acylation
Karthigeyan, K. P.; Zhang, L.; Loiselle, D. R.; Haystead, T. A. J.; Bhat, M.; Yount, J. S.; Kwiek, J. J.
10.1101/2021.05.07.443132 — microbiology — Posted on 2021-05-07
3509 Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells
Melenhorst, J. J.; Chen, G. M.; Wang, M.; Porter, D. . L.; Gao, P.; Bandyopadhyay, S.; Pruteanu-Malinici, I.; Nobles, C. L.; Maji, S.; Frey, N. V.; Gill, S. I.; Tian, L.; Kulikovskaya, I.; Gupta, M.; Davis, M. M.; Fraietta, J. A.; Brogdon, J. L.; Young, R. M.; Ambrose, D. E.; Chew, A.; Levine, B. L.; Siegel, D. L.; Alanio, C.; Wherry, E. J.; Bushman, F. D.; Lacey, S. F.; Tan, K.; June, C. H.
10.1101/2021.05.07.443194 — immunology — Posted on 2021-05-07
3511 Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia
Pasetto, L.; Grassano, M.; Pozzi, S.; Luotti, S.; Sammali, E.; Migazzi, A.; Basso, M.; Spagnolli, G.; Biasini, E.; Micotti, E.; Cerovic, M.; Carli, M.; Forloni, G.; De Marco, G.; Manera, U.; Moglia, C.; Mora, G.; Traynor, B. J.; Chio, A.; Calvo, A.; Bonetto, V.
10.1101/2020.06.08.129528 — neuroscience — Posted on 2021-05-07
3514 A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects
Chakraborty, S.; Diberto, J. F.; Faouzi, A.; bernhard, S. M.; Gutridge, A. M.; Ramsey, S.; Zhou, Y.; Provasi, D.; Nuthikattu, N.; Jilakara, R.; Nelson, M.; Asher, W. B.; Eans, S. O.; Wilson, L. L.; Chintala, S. M.; Filizola, M.; van Rijn, R. M.; Margolis, E. B.; Roth, B. L.; McLaughlin, J. P.; Che, T.; Sames, D.; Javitch, J. A.; majumdar, s.
10.1101/2021.04.22.440994 — pharmacology and toxicology — Posted on 2021-05-07
3515 Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant
Correia, L. W.; Xavier, J. M.; Magno, R.; de Almeida, B. P.; Esteves, F.; Duarte, I.; Eldridge, M.; Sun, C.; Bosma, A.; Mittempergher, L.; Marreiros, A.; Bernards, R.; Caldas, C.; Chin, S.-F.; Maia, A.-T.
10.1101/2021.03.05.434137 — cancer biology — Posted on 2021-05-07
3518 Coil-to-Helix Transition at the Nup358-BicD2 Interface for Dynein Recruitment and Activation
Gibson, J. M.; Cui, H.; Ali, M. Y.; Zhao, X.; Debler, E. W.; Zhao, J.; Trybus, K. M.; Solmaz, S. R.; Wang, C.
10.1101/2021.05.06.443034 — biophysics — Posted on 2021-05-07
3521 Structure and mechanistic features of the prokaryotic minimal RNase P
Feyh, R.; Waeber, N. B.; Prinz, S.; Giammarinaro, P. I.; Bange, G.; Hochberg, G.; Hartmann, R. K.; Altegoer, F.
10.1101/2021.05.07.443126 — biochemistry — Posted on 2021-05-07
3522 Visual information routes in the posterior dorsal and ventral face network studied with intracranial neurophysiology, and white matter tract endpoints
Babo-Rebelo, M.; Puce, A.; Bullock, D.; Hugueville, L.; Pestilli, F.; Adam, C.; Lehongre, K.; Lambrecq, V.; Dinkelacker, V.; George, N.
10.1101/2020.05.22.102046 — animal behavior and cognition — Posted on 2021-05-07
3523 Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function
Rajderkar, S.; Barozzi, I.; Zhu, Y.; Hu, R.; Zhang, Y.; Li, B.; Fukuda-Yuzawa, Y.; Kelman, G.; Akeza, A.; Blow, M. J.; Pham, Q.; Harrington, A. N.; Godoy, J.; Meky, E. M.; von Maydell, K.; Novak, C. S.; Plajzer-Frick, I.; Afzal, V.; Tran, S.; Talkowski, M. E.; Llyod, K. C. K.; Ren, B.; Dickel, D. E.; Visel, A.; Pennacchio, L. A.
10.1101/2021.05.06.443037 — genomics — Posted on 2021-05-07
3528 Alphavirus and flavivirus infectivity is disrupted by components of the bacterial cell wall
Langendries, L.; Jacobs, S.; Abdelnabi, R.; Verwimp, S.; Kaptein, S.; Baatsen, P.; Van Mellaert, L.; Delang, L.
10.1101/2021.05.07.443110 — microbiology — Posted on 2021-05-07
3531 Spatial-temporal targeted and non-targeted surveys to assess microbiological composition of drinking water in Puerto Rico following Hurricane Maria.
Sevillano, M. C.; Vosloo, S.; Cotto, I.; Dai, Z.; Jiang, T.; Santiago Santana, J. M.; Padilla, I. Y.; Rosario-Pabon, Z.; Velez Vega, C.; Cordero, J. F.; Alshawabkeh, A.; Gu, A. Z.; Pinto, A. J.
10.1101/2021.05.07.442998 — microbiology — Posted on 2021-05-07
3532 A four-point measurement probe for brain tissue conductivity and permittivity characterization
Possner, L.; Seebeck, L.; Laukner, M.; Wilhelmy, F.; Lindner, D.; Pliquett, U.; Petkovic, B.; Ziolkowski, M.; Knoesche, T. R.; Weise, K.
10.1101/2021.04.29.441988 — neuroscience — Posted on 2021-05-07
3535 MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline
Moon, J.; Bremer, P.-T.; Mukherjee, P.; Markowitz, A. J.; Palacios, E. M.; Cai, L. T.; Rodriguez, A.; Xiao, Y.; Manley, G. T.; Madduri, R.
10.1101/2020.12.23.424191 — neuroscience — Posted on 2021-05-07
3555 NERD-seq: A novel approach of Nanopore direct RNA sequencing that expands representation of non-coding RNAs
Saville, L.; Cheng, Y.; Gollen, B.; Mitchell, L.; Stuart-Edwards, M.; Haight, T.; Mohajerani, M.; Zovoilis, A.
10.1101/2021.05.06.442990 — genomics — Posted on 2021-05-07
3556 Ozone sensitivity of diverse maize genotypes is associated with differences in gene regulation, not gene content
Nanni, A. V.; Morse, A. M.; Newman, J. R.; Choquette, N. E.; Wedow, J. M.; Liu, Z.; Leakey, A. D.; Conesa, A.; Ainsworth, E. A.; McIntyre, L.
10.1101/2021.05.06.442991 — genomics — Posted on 2021-05-07
3557 Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
Liu, X.; Tong, X.; Zhu, J.; Tian, L.; Jie, Z.; Zou, Y.; Lin, X.; Liang, H.; Li, W.; Ju, Y.; Qin, Y.; Zou, L.; Lu, H.; Xu, X.; Yang, H.; Wang, J.; Zong, Y.; Liu, W.; Hou, Y.; Zhu, S.; Jin, X.; Jia, H.; Zhang, T.
10.1101/2021.05.06.443017 — genetics — Posted on 2021-05-07
3562 Self-assembly of tessellated tissue sheets by growth and collision
Heinrich, M. A.; Alert, R.; Wolf, A. E.; Kosmrlj, A.; Cohen, D. J.
10.1101/2021.05.06.442983 — bioengineering — Posted on 2021-05-07
3563 A phylogeny-based metric for estimating changes in transmissibility from recurrent mutations in SARS-CoV-2
Richard, D.; Shaw, L. P.; Lanfear, R.; Acman, M.; Owen, C.; Tan, C. C. S.; van Dorp, L.; Balloux, F.
10.1101/2021.05.06.442903 — genomics — Posted on 2021-05-07
3564 Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson's Disease and Multiple System Atrophy
Teeple, E.; Joshi, P.; Pande, R. S.; Huang, Y.; Karambe, A.; Latta-Mahieu, M.; Sardi, P.; Cedazo-Minguez, A.; Klinger, K. W.; Flores-Morales, A.; Madden, S. L.; Rajpal, D.; Kumar, D.
10.1101/2021.05.06.442967 — genomics — Posted on 2021-05-07
3566 iCodon: ideal codon design for customized gene expression
Medina-Munoz, S.; Diez, M.; Castellano, L.; da Silva Pescador, G.; Wu, Q.; Bazzini, A. A.
10.1101/2021.05.06.442969 — molecular biology — Posted on 2021-05-07
3567 Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques
Munster, V.; Flagg, M.; Singh, M.; Williamson, B.; Feldmann, F.; Perez-Perez, L.; Brumbaugh, B.; Holbrook, M.; Adney, D.; Okumura, A.; Hanley, P.; Smith, B.; Lovaglio, J.; Anzick, S.; Martens, C.; van Doremalen, N.; Saturday, G.; de Wit, E.
10.1101/2021.05.07.443115 — microbiology — Posted on 2021-05-07
3568 Infection, recovery and re-infection of farmed mink with SARS-CoV-2
Rasmussen, T. B.; Fonager, J.; Jorgensen, C. S.; Lassauniere, R.; Hammer, A. S.; Quaade, M. L.; Boklund, A.; Lohse, L.; Strandbygaard, B.; Rasmussen, M.; Michaelsen, T. Y.; Mortensen, S.; Fomsgaard, A.; Belsham, G. J.; Botner, A.
10.1101/2021.05.07.443055 — microbiology — Posted on 2021-05-07
3569 Theta phase mediates deliberate action switching in human Supplementary Motor Areas
Maffei, G.; Zucca, R.; Puigbo, J. Y.; Santos Pata, D.; Galli, M.; Tauste Campo, A.; Rocamora Zuniga, R.; Verschure, P. F. M. J.
10.1101/2021.05.06.442965 — neuroscience — Posted on 2021-05-07
3573 Independent dynamics of slow, intermediate, and fast intracranial EEG spectral activities during human memory formation
Marks, V. S.; Saboo, K.; Topcu, C.; Thayib, T. P.; Nejedly, P.; Kremen, V.; Worrell, G. A.; Kucewicz, M. T.
10.1101/2021.05.06.442655 — neuroscience — Posted on 2021-05-07
3579 Pharmacologically induced weight loss is associated with distinct gut microbiome changes in obese rats
Raineri, S.; Sherriff, J. A.; Thompson, K. S. J.; Jones, H.; Pfluger, P. T.; Ilott, N. E.; Mellor, J.
10.1101/2021.05.06.442639 — genomics — Posted on 2021-05-07
3580 Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson's Disease and Multiple System Atrophy
Pande, R.; Huang, Y.; Teeple, E.; Joshi, P.; Flores-Morales, A.; Latta- Mahieu, M.; Sardi, S. P.; Cedazo-Minguez, A.; Klinger, K. W.; Madden, S. L.; Rajpal, D.; Kumar, D.
10.1101/2021.05.06.442950 — genomics — Posted on 2021-05-07
3584 Cardioluminescence in transgenic zebrafish embryos: a calcium imaging tool to study drug effects and pathological modeling
Vicente, M.; Salgado-Almario, J.; Collins, M. M.; Martinez-Sielva, A.; Minoshima, M.; Kikuchi, K.; Domingo, B.; Llopis, J.
10.1101/2021.05.06.442917 — physiology — Posted on 2021-05-07
3585 Restoring vascular endothelial autophagic flux reduces atherosclerotic lesions
Chatterjee, S.; Kheloufi, M.; Mazlan, S. M. I.; Loyer, X.; McKinsey, T. A.; Coly, P.-M.; Boulanger, C.
10.1101/2021.05.06.442901 — pathology — Posted on 2021-05-07
3586 massNet: integrated processing and classification of spatially resolved mass spectrometry data using deep learning for rapid tumor delineation
Abdelmoula, W. M.; Stopka, S.; Randall, E. C.; Regan, M.; Agar, J. N.; Sarkaria, J. N.; Wells, W. M.; Kapur, T.; Agar, N. Y. R.
10.1101/2021.05.06.442938 — bioinformatics — Posted on 2021-05-07
3590 Scaling of cellular proteome with ploidy
Yahya, G.; Menges, P.; Ngandiri, D. A.; Schulz, D.; Wallek, A.; Kulak, N. A.; Mann, M.; Cramer, P.; Savage, V.; Raeschle, M.; Storchova, Z.
10.1101/2021.05.06.442919 — cell biology — Posted on 2021-05-07
3591 Intrinsic circadian timekeeping properties of the thalamic lateral geniculate nucleus
Chrobok, L.; Pradel, K.; Janik, M. E.; Sanetra, A. M.; Bubka, M.; Myung, J.; Rahim, A. R.; Klich, J. D.; Jeczmien-Lazur, J. S.; Palus-Chramiec, K.; Lewandowski, M. H.
10.1101/2021.05.06.442920 — neuroscience — Posted on 2021-05-07
3594 Frontostriatal Functional Connectivity Underlies Self-Enhancement During Social Evaluation
Parrish, M. H.; Dutcher, J.; Muscatell, K. A.; Inagaki, T. K.; Moieni, M.; Irwin, M. R.; Eisenberger, N. I.
10.1101/2021.05.07.443090 — neuroscience — Posted on 2021-05-07
3597 Discovery of the fastest myosin, its amino acid sequence, and structural features
Haraguchi, T.; Tamanaha, M.; Suzuki, K.; Yoshimura, K.; Imi, T.; Tominaga, M.; Sakayama, H.; Nishiyama, T.; Murata, T.; Ito, K.
10.1101/2021.05.06.442907 — cell biology — Posted on 2021-05-07
3598 Phenotyping stomatal closure by thermal imaging for GWAS and TWAS of water use efficiency-related genes
Pignon, C.; Fernandes, S.; Valluru, R.; Bandillo, N.; Lozano, R.; Buckler, E. S.; Gore, M. A.; Long, S. P.; Brown, P. J.; Leakey, A.
10.1101/2021.05.06.442962 — plant biology — Posted on 2021-05-07
3602 An estimate of the deepest branches of the tree of life from ancient vertically-evolving genes
Moody, E. R. R.; Mahendrarajah, T. A.; Dombrowski, N.; Clark, J. W.; Petitjean, C.; Offre, P.; Szöllosi, G. J.; Spang, A.; Williams, T. A.
10.1101/2021.01.19.427276 — evolutionary biology — Posted on 2021-05-07
3604 Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA Vaccination
Ramiro de Assis, R.; Jain, A.; Nakajima, R.; Jasinskas, A.; Khan, S.; Palma, A.; Parker, D. M.; Chau, A.; Leung, A.; Christina, C.; Muqolli, F.; Khalil, G.; Colin Escobar, J.; Ventura, J.; Davies, H.; Albala, B.; Boden-Albala, B.; Schubl, S.; Felgner, P. L.
10.1101/2021.04.15.440089 — immunology — Posted on 2021-05-07
3606 Context Free and Context-Dependent Conceptual Representation in the Brain
Gao, Z.; Zheng, L.; Gouws, A.; Krieger-Redwood, K.; Wang, X.; Varga, D.; Smallwood, J.; Jefferies, E.
10.1101/2021.05.03.442424 — neuroscience — Posted on 2021-05-07
3608 LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
Emmenegger, M.; De Cecco, E.; Hruska-Plochan, M.; Eninger, T.; Schneider, M. M.; Barth, M.; Tantardini, E.; de Rossi, P.; Bacioglu, M.; Langston, R. G.; Kaganovich, A.; Bengoa-Vergniory, N.; Gonzalez-Guerra, A.; Avar, M.; Heinzer, D.; Reimann, R.; Häsler, L. M.; Herling, T. W.; Matharu, N. S.; Landeck, N.; Luk, K.; Melki, R.; Kahle, P. J.; Hornemann, S.; Knowles, T. P. J.; Cookson, M. R.; Polymenidou, M.; Jucker, M.; Aguzzi, A.
10.1101/2021.04.25.441302 — neuroscience — Posted on 2021-05-07
3611 The 3D construction of leaves is coordinated with water use efficiency in conifers
Trueba, S.; Theroux-Rancourt, G.; Earles, J. M.; Buckley, T. N.; Love, D.; Johnson, D. M.; Brodersen, C.
10.1101/2021.04.23.441113 — plant biology — Posted on 2021-05-07
3613 Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: The Replica Project
Caruso, M.; Emma, R.; Distefano, A.; Rust, S.; Poulas, K.; Zadjali, F.; Boffo, S.; Volarevic, V.; Mesiakaris, K.; Tobi, M. A.; Giordano, A.; Arsenijevic, A.; Zuccarello, P.; Ferrante, M.; Polosa, R.; Li Volti, G.; Replica Project Group,
10.1101/2021.05.05.442767 — pharmacology and toxicology — Posted on 2021-05-07
3614 The miR-424/503 cluster modulates Wnt/β-catenin signaling in the mammary epithelium by regulating the expression of the LRP6 co-receptor
Nekritz, E. A.; Rodriguez-Barrueco, R.; Yan, K.-K.; Davis, M. L.; Werner, R. L.; Devis-Jauregui, L.; Mukhopadhyay, P.; Yu, J.; Llobet-Navas, D.; Silva, J.
10.1101/2021.05.06.442934 — cancer biology — Posted on 2021-05-07
3615 Targeting Integrated Stress Response by ISRIB combined with imatinib attenuates STAT5 signaling and eradicates therapy-resistant Chronic Myeloid Leukemia cells
Dudka, W.; Hoser, G.; Mondal, S. S.; Turos-Korgul, L.; Swatler, J.; Kusio-Kobiałka, M.; Wolczyk, M.; Klejman, A.; Brewinska-Olchowik, M.; Kominek, A.; Wiech, M.; Machnicki, M. M.; Seferynska, I.; Stoklosa, T.; Piwocka, K.
10.1101/2021.05.05.442756 — cancer biology — Posted on 2021-05-07
3618 Investigating trait variability of gene co-expression network architecture in brain by manipulating genomic signatures of schizophrenia risk
Radulescu, E.; Chen, Q.; Pergola, G.; Eagles, N. J.; Stolz, J. M.; Shin, J. H.; Hyde, T. M.; Kleinman, J. E.; Weinberger, D. R.
10.1101/2021.05.04.442668 — genomics — Posted on 2021-05-07
3619 Heterogeneity of monocyte subsets and susceptibility to influenza virus contribute to inter-population variability of protective immunity
O'Neill, M.; Quach, H.; Pothlichet, J.; Aquino, Y.; Bisiaux, A.; Zidane, N.; Deschamps, M.; Libri, V.; Hasan, M.; Zhang, S.-Y.; Zhang, Q.; Matuozzo, D.; Cobat, A.; Abel, L.; Casanova, J.-L.; Naffakh, N.; Rotival, M.; Quintana-Murci, L.
10.1101/2020.12.07.414151 — genomics — Posted on 2021-05-07
3621 Theory of temperature-dependent consumer-resource interactions
Synodinos, A. D.; Haegeman, B.; Sentis, A.; Montoya, J. M.
10.1101/2020.11.10.376194 — ecology — Posted on 2021-05-07
3622 Nuclear envelope budding is a response to cellular stress
Panagaki, D.; Croft, J. T.; Keuenhof, K.; Larsson-Berglund, L.; Andersson, S.; Kohler, V.; Buettner, S.; Tamas, M. J.; Nystrom, T.; Neutze, R.; Hoog, J.
10.1101/413153 — cell biology — Posted on 2021-05-07
3623 Characterization of cellular, biochemical and genomic features of the diazotrophic plant growth-promoting bacterium Azospirillum sp. UENF-412522, a novel member of the Azospirillum genus
Rodrigues, G. L.; Matteoli, F. P.; Gazara, R. K.; Rodrigues, P. S. L.; dos Santos, S. T.; Alves, A. F.; Pedrosa-Silva, F.; Oliveira-Pinheiro, I.; Canedo-Alvarenga, D.; Olivares, F. L.; Venancio, T. M.
10.1101/2021.05.06.442973 — microbiology — Posted on 2021-05-07
3624 A comprehensive portrait of antimicrobial resistance in the zoonotic pathogen Streptococcus suis
Hadjirin, N. F.; Miller, E. L.; Murray, G. G. R.; Yen, P. L. K.; Phuc, H. D.; Wileman, T. M.; Hernandez-Garcia, J.; Williamson, S. M.; Parkhill, J.; Maskell, D. J.; Zhou, R.; Fittipaldi, N.; Gottschalk, M.; Tucker, A. .W.; Hoa, N. T.; Welch, J. J.; Weinert, L. A.
10.1101/2020.05.05.078493 — microbiology — Posted on 2021-05-07
3627 Deciphering the scopolamine challenge rat model by preclinical functional MRI
Somogyi, G.; Hlatky, D.; Spisak, T.; Spisak, Z.; Nyitrai, G.; Czurko, A.
10.1101/2020.04.08.031534 — neuroscience — Posted on 2021-05-07
3630 Circadian Regulation of Vertebrate Cone Photoreceptor Function
Zang, J.; Gesemann, M.; Keim, J.; Samardzija, M.; Grimm, C.; Neuhauss, S. C.
10.1101/2021.05.05.442714 — neuroscience — Posted on 2021-05-07
3631 Manipulation of carotenoid metabolism stimulates biomass and stress tolerance in tomato
Vallarino, J. G.; Mi, J.; Petrik, I.; Novak, O.; Correa, S. M.; Kosmacz, M.; Havaux, M.; Rodriguez-Concepcion, M.; Al-Babili, S.; Fernie, A. R.; Skirycz, A.; Moreno Beltran, J. C.
10.1101/2021.05.05.442770 — plant biology — Posted on 2021-05-07
3632 Heat Shock Factor 1 (HSF1) as a new tethering factor for ESR1 supporting its action in breast cancer.
Vydra, N.; Janus, P.; Kus, P.; Stokowy, T.; Mrowiec, K.; Toma-Jonik, A.; Krzywon, A.; Cortez, A. J.; Wojtas, B.; Gielniewski, B.; Jaksik, R.; Kimmel, M.; Widlak, W.
10.1101/2021.05.06.442900 — cancer biology — Posted on 2021-05-07
3638 Towards Novel Herbicide Modes of Action by Inhibiting Lysine Biosynthesis in Plants
Soares da Costa, T. P.; Hall, C. J.; Panjikar, S.; Wyllie, J. A.; Christoff, R. M.; Hulett, M. D.; Bayat, S.; Abbott, B. M.; Gendall, A. R.; Perugini, M. A.
10.1101/2021.05.06.442928 — biochemistry — Posted on 2021-05-06
3639 Mangroves are an overlooked hotspot of insect diversity despite low plant diversity
Yeo, D.; Srivathsan, A.; Puniamoorthy, J.; Foo, M.; Grootaert, P.; Chan, L.; Guenard, B.; Damken, C.; Wahab, R. A.; Ang, Y.; Meier, R.
10.1101/2020.12.17.423191 — ecology — Posted on 2021-05-06
3640 Development of Potent and Effective Synthetic SARS-CoV-2 Neutralizing Nanobodies
Stefan, M. A.; Light, Y. K.; Schwedler, J. L.; McIlroy, P. R.; Courtney, C. M.; Saada, E. A.; Thatcher, C. E.; Phillips, A. M.; Bourguet, F. A.; Mageeney, C. M.; McCloy, S. A.; Collette, N. M.; Negrete, O. A.; Schoeniger, J. S.; Weilhammer, D. R.; Harmon, B.
10.1101/2021.05.06.442911 — immunology — Posted on 2021-05-06
3642 Cryptic fertility costs of viral infection in a model social insect
Chapman, A.; Amiri, E.; Han, B.; McDermott, E.; Rueppell, O.; Tarpy, D. R.; Foster, L.; McAfee, A.
10.1101/2021.05.04.442681 — systems biology — Posted on 2021-05-06
3643 An intramolecular scrambling path controlled by a gatekeeper in Xkr8 phospholipid scramblase
Sakuragi, T.; Kanai, R.; Tsutsumi, A.; Narita, H.; Onishi, E.; Miyazaki, T.; Baba, T.; Nakagawa, A.; Kikkawa, M.; Toyoshima, C.; Nagata, S.
10.1101/2021.05.06.442885 — biochemistry — Posted on 2021-05-06
3644 Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes
Sellis, D.; Guerin, F.; Arnaiz, O.; Pett, W.; Lerat, E.; Boggetto, N.; Krenek, S.; Berendonk, T.; Couloux, A.; Aury, J.-M.; Labadie, K.; Malinski, S.; Meyer, E.; Sperling, L.; Duret, L.; Duharcourt, S.
10.1101/2020.12.23.424184 — genomics — Posted on 2021-05-06
3645 A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress
Kershaw, E. E.; Kanshana, J. S.; Mattila, P. E.; Ewing, M. C.; Wood, A. N.; Schoiswohl, G.; Meyer, A. C.; Kowalski, A.; Rosenthal, S. L.; Gingras, S.; Kaufman, B. A.; Lu, R.; Weeks, D. E.; McGarvey, S. T.; Minster, R. L.; Hawley, N. L.
10.1101/2021.05.06.442909 — genetics — Posted on 2021-05-06
3648 From theory to experiment and back again -- Challenges in quantifying a trait-based theory of predator-prey dynamics
Wootton, K.; Curtsdotter, A.; Jonsson, T.; Banks, H. T.; Roslin, T.; Bommarco, R.; Laubmeier, A.
10.1101/2021.05.06.442910 — ecology — Posted on 2021-05-06
3649 Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx
Martin, M. M.; Matkovic, R.; Larrous, P.; Morel, M.; Lasserre, A.; Vauthier, V.; Margottin-Goguet, F.
10.1101/2021.05.06.442913 — microbiology — Posted on 2021-05-06
3651 Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques
Irvine, E. B.; O'Neil, A.; Darrah, P. A.; Shin, S.; Choudhary, A.; Li, W.; Honnen, W.; Mehra, S.; Kaushal, D.; Gideon, H. P.; Flynn, J. L.; Roederer, M.; Seder, R. A.; Pinter, A.; Fortune, S.; Alter, G.
10.1101/2021.05.06.442979 — immunology — Posted on 2021-05-06
3652 Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.
Candela, M. E.; Allsop, D. J. P.; Carter, R. N.; Semple, F.; Kilanowski, F.; Webb, S.; Taggart, D.; Mullan, H. J. W.; McHugh, B. J.; Dockrell, D. H.; Davidson, D. J.; Allen, J. E.; Jenkins, S. J.; Morton, N. M.; Dorin, J. R.
10.1101/2021.05.06.442606 — immunology — Posted on 2021-05-06
3653 Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures and hypoactivity
Hotz, A. L.; Jamali, A.; Rieser, N. N.; Niklaus, S.; Aydin, E.; Myren-Svelstad, S.; Lalla, L.; Jurisch-Yaksi, N.; Yaksi, E.; Neuhauss, S. C. F.
10.1101/2021.03.16.435577 — neuroscience — Posted on 2021-05-06
3654 Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish
Odstrcil, I.; Petkova, M. D.; Haesemeyer, M.; Boulanger-Weill, J.; Nikitchenko, M.; Gagnon, J. A.; Oteiza, P.; Schalek, R.; Peleg, A.; Portugues, R.; Lichtman, J.; Engert, F.
10.1101/2021.05.04.442674 — neuroscience — Posted on 2021-05-06
3657 InterARTIC: an interactive web application for whole-genome nanopore sequencing analysis of SARS-CoV-2 and other viruses
Ferguson, J. M.; Gamaarachchi, H.; Nguyen, T.; Gollon, A.; Tong, S.; Aquilina-Reid, C.; Bowen-James, R.; Deveson, I. W.
10.1101/2021.04.21.440861 — bioinformatics — Posted on 2021-05-06
3660 Temperature drives variation in flying insect biomass across a German malaise trap network
Welti, E. A. R.; Zajicek, P.; Ayasse, M.; Bornholdt, T.; Buse, J.; Dziock, F.; Engelmann, R. A.; Englmeier, J.; Fellendorf, M.; Foerschler, M. I.; Frenzel, M.; Fricke, U.; Ganuza, C.; Hippke, M.; Hoenselaar, G.; Kaus-Thiel, A.; Mandery, K.; Marten, A.; Monaghan, M. T.; Morkel, C.; Muller, J.; Puffpaff, S.; Redlich, S.; Richter, R.; Rojas Botero, S.; Scharnweber, T.; Scheiffarth, G.; Schmidt Yanez, P.; Schumann, R.; Seibold, S.; Steffan-Dewenter, I.; Stoll, S.; Tobisch, C.; Twietmeyer, S.; Uhler, J.; Vogt, J.; Weis, D.; Weisser, W. W.; Wilmking, M.; Haase, P.
10.1101/2021.02.02.429363 — ecology — Posted on 2021-05-06
3661 Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia
Park, H.; Furtado, J.; Poulet, M.; Chung, M.; Yun, S.; Lee, S.; Sessa, W. C.; Franco, C. A.; Schwartz, M. A.; Eichmann, A.
10.1101/2021.05.06.442985 — cell biology — Posted on 2021-05-06
3662 Wnt-and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
Junyent, S.; Reeves, J. C.; Szczerkowski, J. L. A.; Garcin, C. L.; Trieu, T.-J.; Wilson, M.; Lundie-Brown, J.; Habib, S. J. J.
10.1101/2020.06.16.154609 — cell biology — Posted on 2021-05-06
3663 GIV/Girdin, a Non-receptor Modulator for Gαi/s, Regulates Spatiotemporal Signaling during Sperm Capacitation and is Required for Male Fertility
Reynoso, S.; Castillo, V.; Katkar, G. D.; Lopez-Sanchez, I.; Taheri, S.; Espinoza, C. R.; Rohena, C.; Sahoo, D.; Gagneux, P.; Ghosh, P.
10.1101/2021.05.06.442927 — cell biology — Posted on 2021-05-06
3665 Network alignment and similarity reveal atlas-based topological differences in structural connectomes
Frigo, M.; Cruciani, E.; Coudert, D.; Deriche, R.; Natale, E.; Deslauriers-Gauthier, S.
10.1101/2020.12.16.422501 — neuroscience — Posted on 2021-05-06
3666 Basal forebrain cholinergic neurons are part of the threat memory engram
Rajebhosale, P.; Ananth, M. R.; Crouse, R. B.; Jiang, L.; Lopez- Hernandez, G.; Arty, C.; Wang, S.; Jone, A.; Zhong, C.; Desai, N.; Li, Y.; Picciotto, M.; Role, L. W.; Talmage, D. A.
10.1101/2021.05.02.442364 — neuroscience — Posted on 2021-05-06
3667 Redefining the role of Ca2+-permeable channels in photoreceptor degeneration using diltiazem
Das, S.; Popp, V.; Power, M. J.; Groeneveld, K.; Melle, C.; Rogerson, L. E.; Achury, M. N.; Schwede, F.; Strasser, T.; Euler, T.; Paquet-Durand, F.; Nache, V.
10.1101/2020.12.04.411827 — neuroscience — Posted on 2021-05-06
3672 Stimulus manipulations permit activation of fiber subpopulations in the mouse and rat vagus
Chang, Y.-C.; Ahmed, U.; Jayaprakash, N.; Mughrabi, I.; Lin, Q.; Wu, Y.-C.; Abbas, A.; Gabalski, A. H.; Daytz, A.; Ashville, J.; Dokos, S.; Guo, T.; Al-Abed, Y.; Zanos, S.
10.1101/2021.01.30.428827 — bioengineering — Posted on 2021-05-06
3673 Alpha satellite insertion close to an ancestral centromeric region
Giannuzzi, G.; Logsdon, G. A.; CHATRON, N.; Miller, D. E.; Reversat, J.; Munson, K. M.; Hoekzema, K.; Bonnet-Dupeyron, M.-N.; Rollat-Farnier, P.-A.; Baker, C. A.; Sanlaville, D.; Eichler, E. E.; Schluth-Bolard, C.; Reymond, A.
10.1101/2021.03.10.434819 — genetics — Posted on 2021-05-06
3675 Rapid, but limited, zooplankton adaptation to simultaneous warming and acidification
Dam, H. G.; deMayo, J. A.; Park, G.; Norton, L.; He, X.; Finiguerra, M. B.; Baumann, H.; Brennan, R. S.; Pespeni, M. H.
10.1101/2021.04.07.438881 — evolutionary biology — Posted on 2021-05-06
3679 Insights into the L3 to L4 developmental program through proteomics
Bennuru, S.; Meng, Z.; McKerrow, J. H.; Lustigman, S.; Nutman, T. B.
10.1101/2021.05.06.439182 — microbiology — Posted on 2021-05-06
3680 PspA adopts an ESCRT-III-like fold and remodels bacterial membranes
Junglas, B.; Huber, S. T.; Heidler, T.; Schloesser, L.; Mann, D.; Hennig, R.; Clarke, M.; Hellmann, N.; Schneider, D.; Sachse, C.
10.1101/2020.09.23.309765 — microbiology — Posted on 2021-05-06
3681 Integration of chemosensing and carbon catabolite repression impacts fungal enzyme regulation and plant associations
Hinterdobler, W.; Li, G.; Turra, D.; Schalamun, M.; Kindel, S.; Sauer, U.; Beier, S.; Rodriguez-Iglesias, A.; Compant, S.; Vitale, S.; Di Pietro, A.; Schmoll, M.
10.1101/2021.05.06.442915 — microbiology — Posted on 2021-05-06
3682 Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques
Irvine, E. B.; O'Neil, A.; Darrah, P. A.; Shin, S.; Choudhary, A.; Li, W.; Honnen, W.; Mehra, S.; Kaushal, D.; Gideon, H. P.; Flynn, J. L.; Roederer, M.; Seder, R. A.; Pinter, A.; Fortune, S.; Alter, G.
10.1101/2021.05.06.442979 — immunology — Posted on 2021-05-06
3683 The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair
McCowan, J.; Kirkwood, P. M.; Fercoq, F.; T'Jonck, W.; Mawer, C. M.; Cunningham, R.; Mirchandani, A. S.; Hoy, A. M.; Jones, G.-R.; Hansen, C. G.; Hirani, N.; Jenkins, S. J.; Henri, S.; Malissen, B.; Walmsley, S. R.; Dockrell, D. H.; Saunders, P.; Carlin, L. M.; Bain, C. C.
10.1101/2021.05.06.442095 — immunology — Posted on 2021-05-06
3685 Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response
Esmaeili, V.; Tamura, K.; Muscinelli, S. P.; Modirshanechi, A.; Boscaglia, M.; Lee, A. B.; Oryshchuk, A.; Foustoukos, G.; Liu, Y.; Crochet, S.; Gerstner, W.; Petersen, C. C. H.
10.1101/2020.10.06.326678 — neuroscience — Posted on 2021-05-06
3686 Forebrain Shh overexpression improves cognitive function in a Down syndrome mouse model and euploid littermates
Gao, F. J.; Klinedinst, D.; Fernandez, F.-X.; Cheng, B.; Savonenko, A.; Devenney, B.; Li, Y.; Wu, D.; Pomper, M. G.; Reeves, R. H.
10.1101/2021.01.18.427185 — neuroscience — Posted on 2021-05-06
3687 BigBrainWarp: Toolbox for integration of BigBrain 3D histology with multimodal neuroimaging
Paquola, C.; Royer, J.; Lewis, L. B.; Lepage, C.; Glatard, T.; Wagstyl, K.; DeKraker, J.; Toussaint, P.-J.; Valk, S. L.; Collins, D. L.; Khan, A.; Amunts, K.; Evans, A. C.; Dickscheid, T.; Bernhardt, B.
10.1101/2021.05.04.442563 — neuroscience — Posted on 2021-05-06
3689 Partitioning variability in animal behavioral videos using semi-supervised variational autoencoders
Whiteway, M. R.; Biderman, D.; Friedman, Y.; Dipoppa, M.; Buchanan, E. K.; Wu, A.; Zhou, J.; Noel, J.-P. R.; The International Brain Lab, ; Cunningham, J. P.; Paninski, L.
10.1101/2021.02.22.432309 — neuroscience — Posted on 2021-05-06
3692 Competitive dynamics underlie cognitive improvements during sleep.
Chen, P.-C.; Niknazar, H.; Alaynick, W. A.; Whitehurst, L. N.; Mednick, S. C.
10.1101/2021.03.31.437952 — neuroscience — Posted on 2021-05-06
3693 Effect of sublethal prenatal endotoxaemia on murine placental transport systems and lipid homeostasis
Reginatto, M. W.; Fontes, K. N.; Monteiro, V. S.; Liacone, N.; Andrade, C. B.; Gomes, H. R.; Imperio, G. E.; Bloise, F. F.; Kluck, G.; Atella, G.; Matthews, S.; Bloise, E.; Ortiga-Carvalho, T. M.
10.1101/2020.08.04.236745 — physiology — Posted on 2021-05-06
3695 Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit
Ashley, B.; Simner, C.; Manousopoulou, A.; Jenkinson, C.; Hey, F.; Frost, J. M.; Rezwan, F. I.; White, C. H.; Lofthouse, E. M.; Hyde, E.; Cooke, L.; Barton, S.; Mahon, P.; Curtis, E. M.; Moon, R. J.; Crozier, S. R.; Inskip, H. M.; Godfrey, K. M.; Holloway, J. W.; Cooper, C.; Jones, K. S.; Lewis, R. M.; Hewison, M.; Garbis, S. D.; Branco, M. R.; Harvey, N. C.; Cleal, J. K.
10.1101/2021.03.01.431439 — physiology — Posted on 2021-05-06
3698 Raabin-WBC: a large free access dataset of white blood cells from normal peripheral blood
Mousavi Kouzehkanan, Z.; Saghari, S.; Tavakoli, E.; Rostami, P.; AbbasZadeh, M.; Mirzadeh, F.; Shahabi Satlsar, E.; Gheidishahran, M.; Gorgi, F.; Mohammadi, S.; Hosseini, R.
10.1101/2021.05.02.442287 — bioengineering — Posted on 2021-05-06
3704 Endothelial Unc5B controls blood-brain barrier integrity
Boye, K.; Geraldo, L. H. M.; furtado, J.; Pibouin-fragner, L.; Poulet, M.; Kim, D.; Nelson, B.; Xu, Y.; Jacob, L.; Maissa, N.; Tavitian, B.; Agalliu, D.; Claesson-Welsh, L.; Ackerman, S.; Eichmann, A.
10.1101/2021.05.06.442974 — cell biology — Posted on 2021-05-06
3705 Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to induce autophagy
Goyal, S.; Segarra, V. A.; Stecher, A. M.; Nitika, ; Truman, A. W.; Reitzel, A. M.; Chi, R. J.
10.1101/2021.05.06.441257 — cell biology — Posted on 2021-05-06
3709 Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activator
Lopez Escobar, L.; Hanisch, B.; Halliday, C.; Dean, S.; Sunter, J.; Wheeler, R. J.; Gull, K.
10.1101/2021.05.06.442931 — microbiology — Posted on 2021-05-06
3710 The neuropeptide receptor NMUR-1 regulates the specificity of C. elegans innate immunity against pathogen infection
Wibisono, P.; Wibisono, S.; Watteyne, J.; Chen, C.-H.; Sellegounder, D.; Beets, I.; Liu, Y.; Sun, J.
10.1101/2021.05.06.442992 — microbiology — Posted on 2021-05-06
3711 Characterization of cellular, biochemical and genomic features of the diazotrophic plant growth-promoting bacterium Azospirillum sp. UENF-412522, a novel member of the Azospirillum genus
Rodrigues, G. L.; Matteoli, F. P.; Gazara, R. K.; Rodrigues, P. S. L.; dos Santos, S. T.; Alves, A. F.; Pedrosa-Silva, F.; Oliveira-Pinheiro, I.; Canedo-Alvarenga, D.; Olivares, F. L.; Venancio, T. M.
10.1101/2021.05.06.442973 — microbiology — Posted on 2021-05-06
3717 KAI2 regulates seedling development by mediating light-induced remodelling of auxin transport
Hamon-Josse, M.; Villaecija-Aguilar, J.; Ljung, K.; Leyser, O.; Gutjahr, C.; Bennett, T.
10.1101/2021.05.06.443001 — plant biology — Posted on 2021-05-06
3718 DNA damage and macrophage infiltration in the ovaries of the long-lived GH deficient Ames Dwarf and the short-lived bGH transgenic mice
Saccon, T. D.; Rovani, M.; Garcia, D.; Pradiee, J.; Mondadori, R.; Cruz, L.; Barros, C.; Fang, Y.; McFaden, S.; Bartke, A.; masternak, M.; Schneider, A.
10.1101/2020.01.19.911677 — physiology — Posted on 2021-05-06
3719 Photonic chip-based multimodal super-resolution microscopy for histopathological assessment of cryopreserved tissue sections
Villegas-Hernandez, L. E.; Dubey, V. K.; Nystad, M.; Tinguely, J.-C.; Coucheron, D. A.; Dullo, F. T.; Priyadarshi, A.; Acuna, S.; Mateos, J. M.; Barmettler, G.; Ziegler, U.; Hovd, A.-M. K.; Fenton, K. A.; Acharya, G.; Agarwal, K.; Ahluwalia, B. S.
10.1101/2021.05.06.442952 — pathology — Posted on 2021-05-06
3720 Ser/Thr phospho-regulation by PknB and Stp mediates bacterial quiescence and antibiotic persistence in Staphylococcus aureus
Huemer, M.; Mairpady Shambat, S.; Pereira, S.; Van Gestel, L.; Bergada-Pijuan, J.; Gomez Mejia, A.; Chang, C.-C.; Vulin, C.; Baer, J.; Dworkin, J.; Zinkernagel, A. S.
10.1101/2021.05.06.442895 — microbiology — Posted on 2021-05-06
3721 Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen
Mac Kain, A.; Maarifi, G.; Aicher, S.-M.; Arhel, N.; Baidaliuk, A.; Vallet, T.; Tran, Q. D.; Hardy, A.; Chazal, M.; Porrot, F.; Ohainle, M.; Carlson-Stevermer, J.; Oki, J.; Holden, K.; Simon-Loriere, E.; Bruel, T.; Schwartz, O.; Jouvenet, N.; Nisole, S.; Vignuzzi, M.; Roesch, F.
10.1101/2021.05.06.442916 — microbiology — Posted on 2021-05-06
3724 Paired SARS-CoV-2 Spike Protein Mutations Observed During Ongoing SARS-CoV-2 Viral Transfer from Humans to Minks and Back to Humans
Rubsamen, R.; Burkholz, S.; Pokhrel, S.; Kraemer, B. R.; Mochly-Rosen, D.; Carback, R. T.; Hodge, T.; Harris, P.; Ciotlos, S.; Wang, L.; Herst, C.
10.1101/2020.12.22.424003 — genetics — Posted on 2021-05-06
3725 Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection
Schimmel, L.; Chew, K. Y.; Stocks, C.; Yordanov, T.; Essebier, P.; Kulasinghe, A.; Monkman, J.; Miggiolaro, A. F. R. d. S.; Cooper, C.; De Noronha, L.; Lagendijk, A. K.; Schroder, K.; Labzin, L.; Gordon, E. J.; Short, K. R.
10.1101/2021.02.14.431177 — cell biology — Posted on 2021-05-06
3726 The Effect of Minnelide against SARS-CoV-2 in a Murine Model
Caballero Van Dyke, M. C.; Mead, H. L.; Bryant, M.; Laux, K. L.; Kollath, D. R.; Coyne, V. K.; Miller, K. J.; Stone, N. E.; Jaramillo, S. A.; Keim, P.; Milikowski, C.; Gupta, V. K.; Vickers, S. M.; Saluja, A.; Velagapudi, M. R.; Barker, B. M.
10.1101/2021.05.05.442875 — microbiology — Posted on 2021-05-06
3728 Diversity and selection of SARS-CoV-2 minority variants in the early New York City outbreak
Roder, A.; Khalfan, M.; Johnson, K. E.; Ruchnewitz, D.; Knoll, M.; Banakis, S.; Wang, W.; Samanovic, M. I.; Mulligan, M. J.; Gresham, D.; Laessig, M.; Luksza, M.; Ghedin, E.
10.1101/2021.05.05.442873 — microbiology — Posted on 2021-05-06
3730 DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation
Liu, Y.; Rosikiewicz, W.; Pan, Z.; Jillette, N.; Taghbalout, A.; Foox, J.; Mason, C.; Carroll, M.; Cheng, A.; Li, S.
10.1101/2021.05.05.442849 — bioinformatics — Posted on 2021-05-06
3735 A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Mahoney, M.; Damalanka, V. C.; Tartell, M.; Chung, D. H.; Lourenco, A. L.; Pwee, D.; Mayer Bridwell, A. E.; Hoffmann, M.; Voss, J.; Karmakar, P.; Azouz, N. P.; Klinger, A. M.; Rothlauf, P. W.; Thompson, C. E.; Lee, M.; Klampfer, L.; Stallings, C.; Rothenberg, M. E.; Pöhlmann, S.; Whelan, S. P. J.; O'Donoghue, A. J.; Craik, C. S.; Janetka, J. W.
10.1101/2021.05.06.442935 — microbiology — Posted on 2021-05-06
3736 Discovery of an Antarctic ascidian-associated uncultivated Verrucomicrobia that encodes antimelanoma palmerolide biosynthetic capacity
Murray, A. E.; Lo, C.-C.; Daligault, H.; Avalon, N. E.; Read, R. W.; Davenport, K. W.; Higham, M. L.; Kunde, Y.; Dichosa, A. E. K.; Baker, B. J.; Chain, P. S. G.
10.1101/2021.05.05.442870 — microbiology — Posted on 2021-05-06
3737 Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity
Olmedillas, E.; Mann, C. J.; Peng, W.; Wang, Y.-T.; Diaz Avalos, R.; Bedinger, D.; Valentine, K.; Shafee, N.; Schendel, S. L.; Yuan, M.; Lang, G.; Rouet, R.; Christ, D.; Jiang, W.; Wilson, I. A.; Germann, T.; Shresta, S.; Snijder, J.; Ollmann Saphire, E.
10.1101/2021.05.06.441046 — microbiology — Posted on 2021-05-06
3741 Somatic genetics analysis of sleep in adult mice
Liu, Q.; Wang, F.; Wang, G.; Li, Q.; Xu, J.; Zhao, S.; Zhou, R.; Chen, Z.; Jiang, W.; Gao, X.; Zhou, S.; Chen, Z.; Sun, Q.; Ma, C.; Chen, L.; Shi, B.; Guo, Y.; Wang, H.; Wang, X.; Li, H.; Cai, T.; Wang, Y.; Chen, Z.
10.1101/2021.05.05.442860 — neuroscience — Posted on 2021-05-06
3743 Precision environmental health monitoring by longitudinal exposome and multi-omics profiling
Gao, P.; Shen, X.; Zhang, X.; Jiang, C.; Zhang, S.; Zhou, X.; Rose, S. M. S.-F.; Snyder, M.
10.1101/2021.05.05.442855 — systems biology — Posted on 2021-05-06
3747 Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues
Herbig, M.; Tessmer, K.; Noetzel, M.; Nawaz, A. A.; Santos-Ferreira, T.; Borsch, O.; Gasparini, S.; Guck, J.; Ader, M.
10.1101/2021.05.05.442869 — biophysics — Posted on 2021-05-06
3750 Spatial and ecological drivers of population structure in Alkanna tinctoria (Boraginaceae), a polyploid medicinal herb
Ahmad, M.; Leroy, T.; Krigas, N.; Temsch, E. M.; Weiss-Schneeweiss, H.; Lexer, C.; Sehr, E. M.; Paun, O.
10.1101/2021.05.06.442843 — genomics — Posted on 2021-05-06
3753 Genetic, Genomic and Biophysical Case Study: Familial 46, XY Sex Reversal due to a Novel Inherited Mutation in Human Testis-Determining Factor SRY
Vaiani, E.; Chen, Y.-S.; Ramirez, P.; Racca, J. D.; Baqudano, M. S.; Malosetti, C.; Touzon, M. S.; Marino, R.; Costanzo, M.; Bailez, M.; Berensztein, E.; Galluzzo-Mutti, M. L.; Chatterjee, D.; Yang, Y.; Belgorosky, A.; Weiss, M. A.
10.1101/2021.05.05.442859 — developmental biology — Posted on 2021-05-06
3754 Maternal iron deficiency impacts the placental arterial network.
Kalisch-Smith, J. I.; Morris, E. C.; Strevens, M. A.; Redpath, A. N.; Klaourakis, K.; Szumska, D.; Outhwaite, J. E.; Vieira, J. M.; Smart, N.; De Val, S.; Riley, P. R.; Sparrow, D. B.
10.1101/2021.05.06.442902 — developmental biology — Posted on 2021-05-06
3755 Growth-dependent heterogeneity in the DNA damage response in Escherichia coli
Jaramillo-Riveri, S.; Broughton, J.; McVey, A.; Scott, M.; El Karoui, M.
10.1101/2021.05.06.442821 — cell biology — Posted on 2021-05-06
3761 Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning
Wills, J. W.; Verma, J. R.; Rees, B. J.; Harte, D. S. G.; Haxhiraj, Q.; Barnes, C. M.; Barnes, R.; Rodrigues, M. A.; Doan, M.; Filby, A.; Hewitt, R. E.; Thornton, C. A.; Cronin, J. G.; Kenny, J. D.; Buckley, R.; Carpenter, A. E.; Lynch, A. M.; Summers, H. D.; Johnson, G.; Rees, P.
10.1101/2021.05.05.442619 — pharmacology and toxicology — Posted on 2021-05-06
3763 Blood-based liquid biopsy for comprehensive cancer genomic profiling using next-generation sequencing: an emerging paradigm for noninvasive cancer detection and management in dogs
Kruglyak, K. M.; Chibuk, J.; McLennan, L.; Nakashe, P.; Hernandez, G. E.; Motalli-Pepio, R.; Fath, D. M.; Tynan, J. A.; Holtvoigt, L. E.; Chorny, I.; Grosu, D. S.; Tsui, D. W.; Flory, A.
10.1101/2021.05.05.442773 — genomics — Posted on 2021-05-06
3764 SWAN Identification of Common Aneuploidy-Based Oncogenic Drivers
Bowers, R. R.; Jones, C. M.; Paz, E. A.; Barrows, J. K.; Armeson, K. E.; Long, D. T.; Delaney, J. R.
10.1101/2021.05.05.442642 — genetics — Posted on 2021-05-06
3766 Metamorphosis imposes variable constraints on genome expansion
Mueller, R. L.; Cressler, C. E.; Schwarz, R. S.; Chong, R. A.; Butler, M. A.
10.1101/2021.05.05.442795 — evolutionary biology — Posted on 2021-05-06
3768 Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity
Riera-Tur, I.; Schaefer, T.; Hornburg, D.; Mishra, A.; Fernandez-Mosquera, L.; Feigenbutz, D.; Auer, P.; Mann, M.; Baumeister, W.; Klein, R.; Meissner, F.; Raimundo, N.; Fernandez-Busnadiego, R.; Dudanova, I.
10.1101/2019.12.16.877431 — cell biology — Posted on 2021-05-06
3770 Dual-color optical activation and suppression of neurons with high temporal precision
Mermet-Joret, N.; Moreno, A.; Zbela, A.; Ellendersen, B. E.; Krauth, N.; von Philipsborn, A.; Piriz, J.; Lin, J. Y.; Nabavi, S.
10.1101/2021.05.05.442824 — neuroscience — Posted on 2021-05-06
3772 A novel mouse model of focal limbic seizures that reproduces behavioral impairment associated with cortical slow wave activity
Sieu, L.-A.; Singla, S.; Sharafeldin, A.; Chandrasekaran, G.; Valcarce-Aspegren, M.; Niknahad, A.; Fu, I.; Doilicho, N.; Gummadavelli, A.; McCafferty, C. P.; Crouse, R. B.; Perrenoud, Q.; Picciotto, M.; Cardin, J. A.; Blumenfeld, H.
10.1101/2021.05.05.442811 — neuroscience — Posted on 2021-05-06
3773 QSMxT: Robust Masking and Artefact Reduction for Quantitative Susceptibility Mapping
Stewart, A. W.; Robinsons, S. D.; O'Brien, K.; Jin, J.; Widhalm, G.; Hangel, G.; Walls, A.; Goodwin, J.; Eckstein, K.; Tourell, M.; Morgan, C.; Narayanan, A.; Barth, M.; Bollmann, S.
10.1101/2021.05.05.442850 — neuroscience — Posted on 2021-05-06
3775 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity
Mobbs, J.; Belousoff, M. J.; Harikumar, K. G.; Piper, S. J.; Xu, X.; Furness, S. G. B.; Venugopal, H.; Christopoulos, A.; Danev, R.; Wootten, D.; Thal, D. M.; Miller, L. J.; Sexton, P. M.
10.1101/2021.05.06.442871 — pharmacology and toxicology — Posted on 2021-05-06
3777 Predicting T Cell Quality During Manufacturing Through an Artificial Intelligence-based Integrative Multi-Omics Analytical Platform
Odeh-Couvertier, V. Y.; Dwarshuis, N. J.; Colonna, M. B.; Levine, B. L.; Edison, A. S.; Kotanchek, T.; Roy, K.; Torres-Garcia, W.
10.1101/2021.05.05.442854 — bioengineering — Posted on 2021-05-06
3778 Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium
Sha, Z.; Rooij, D. v.; Anagnostou, E.; Arango, C.; Auzias, G.; Behrmann, M.; Bernhardt, B.; Bolte, S.; Busatto, G. F.; Calderoni, S.; Calvo, R.; Daly, E.; Deruelle, C.; Duan, M.; Duran, F. L. S.; Durston, S.; Ecker, C.; Ehrlich, S.; Fair, D.; Fedor, J.; Fitzgerald, J.; Floris, D. L.; Franke, B.; Freitag, C. M.; Gallagher, L.; Glahn, D. C.; Haar, S.; Hoekstra, L.; Jahanshad, N.; Jalbrzikowski, M.; Janssen, J.; King, J. A.; Lazaro, L.; Luna, B.; McGrath, J.; Medland, S. E.; Molloy, C.; Muratori, F.; Murphy, D. G. M.; Neufeld, J.; O'Hearn, K.; Oranje, B.; Parellada, M.; Pariente, J.; Postema, M.
10.1101/2021.05.05.442735 — neuroscience — Posted on 2021-05-06
3780 Exploitation of sulfated glycosaminoglycan status for precision medicine of platinums in triple-negative breast cancer
Hampton, J. D.; Peterson, E. J.; Katner, S. J.; Turner, T. H.; Alzubi, M. A.; Harrell, J. C.; Dozmorov, M. G.; Gigliotti, P. J.; Kraskauskiene, V.; Shende, M.; Idowu, M. O.; Puchalapalli, M.; Hu, B.; Litovchick, L.; Katsuta, E.; Takabe, K.; Farrell, N. P.; Koblinski, J. E.
10.1101/2021.05.05.442616 — pharmacology and toxicology — Posted on 2021-05-06
3781 The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel
Pipatpolkai, T.; Usher, S. G.; Vedovato, N.; Ashcroft, F. M.; Stansfeld, P. J.
10.1101/2021.05.06.442933 — biochemistry — Posted on 2021-05-06
3782 Covalent Flexible Peptide Docking in Rosetta
Tivon, B.; Gabizon, R.; Somsen, B. A.; Cossar, P. J.; Ottmann, C.; London, N.
10.1101/2021.05.06.441297 — biochemistry — Posted on 2021-05-06
3784 Mechanistic Insights of High Temperature-Interfered Meiosis in Autotetraploid Arabidopsis thaliana
Fu, H.; Yang, K.; Zhang, X.; Zhao, J.; Elesawi, I. E.; Liu, H.; Xia, J.; Yu, G.; Chen, C.; Wang, C.; Liu, B.
10.1101/2021.05.05.442845 — plant biology — Posted on 2021-05-06
3785 Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids
Dekkers, J. F.; Alieva, M.; Cleven, A.; Keramati, F.; Brazda, P.; Rebel, H. G.; Wezenaar, A. K. L.; Puschhof, J.; Buchholz, M.-B.; Barrera Roman, M.; Johanna, I.; Meringa, A. D.; Fasci, D.; Geurts, M. H.; Ariese, H. C. R.; van Vliet, E. J.; van Ineveld, R. L.; Karaiskaki, E.; Kopper, O.; Bar-Ephraim, Y. E.; Kretzschmar, K.; Eggermont, A. M. M.; Wehrens, E. J.; Stunnenberg, H. G.; Clevers, H.; Kuball, J.; Sebestyen, Z.; Rios, A. C.
10.1101/2021.05.05.442764 — cancer biology — Posted on 2021-05-06
3787 Raabin-WBC: a large free access dataset of white blood cells from normal peripheral blood
Mousavi Kouzehkanan, S.-Z.; Saghari, S.; Tavakoli, E.; Rostami, P.; AbbasZadeh, M.; Mirzadeh, F.; Shahabi Satlsar, E.; Gheidishahran, M.; Gorgi, F.; Mohammadi, S.; Hosseini, R.
10.1101/2021.05.02.442287 — bioengineering — Posted on 2021-05-06
3788 Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin
King, H.; Ajay Castro, S.; Arunrao Pohane, A.; Scholte, C. M.; Fischetti, V. A.; Korotkova, N.; Nelson, D. C.; Dorfmueller, H. C.
10.1101/2021.03.19.436156 — biochemistry — Posted on 2021-05-06
3792 Derivation of ringed seal (Phoca hispida) induced multipotent stem cells
Beklemisheva, V. R.; Belokopytova, P. S.; Fishman, V. S.; Menzorov, A. G.
10.1101/2020.05.20.105890 — developmental biology — Posted on 2021-05-06
3793 Vascular tropism models of blood-borne microbial dissemination
Boczula, A. E.; Ly, A.; Ebady, R.; Cho, J.; Anjum, Z.; Zlotnikov, N.; Persson, H.; Odisho, T.; Simmons, C. A.; Moriarty, T. J.
10.1101/2021.05.05.442761 — microbiology — Posted on 2021-05-06
3794 Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease
Merk, T.; Peterson, V.; Lipski, W.; Blankertz, B.; Turner, R. S.; Li, N.; Horn, A.; Kuehn, A.; Richardson, M.; Neumann, W.-J.
10.1101/2021.04.24.441207 — neuroscience — Posted on 2021-05-06
3795 BigBrainWarp: Toolbox for integration of BigBrain 3D histology with multimodal neuroimaging
Paquola, C.; Royer, J.; Lewis, L. B.; Lepage, C.; Glatard, T.; Wagstyl, K.; DeKraker, J.; Toussaint, P.-J.; Valk, S. L.; Collins, D. L.; Khan, A.; Amunts, K.; Evans, A. C.; Dickscheid, T.; Bernhardt, B.
10.1101/2021.05.04.442563 — neuroscience — Posted on 2021-05-06
3797 Associations between ADHD symptom remission and white matter microstructure: a longitudinal analysis
Damatac, C. G.; Leenders, A. E. M.; Soheili-Nezhad, S.; Chauvin, R. J. M.; Mennes, M. J. J.; Zwiers, M. P.; van Rooij, D.; Akkermans, S. E. A.; Naaijen, J.; Franke, B.; Buitelaar, J. K.; Beckmann, C. F.; Sprooten, E.
10.1101/2020.09.24.311654 — neuroscience — Posted on 2021-05-06
3799 T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function
Brandi, J.; Lehmann, C.; Kaminski, L.-C.; Schulze zur Wiesch, J.; Addo, M.; Ramharter, M.; Mackroth, M.; Jacobs, T.; Riehn, M.
10.1101/2021.04.19.440453 — immunology — Posted on 2021-05-06
3800 distinct: a novel approach to differential distribution analyses
Tiberi, S.; Crowell, H. L.; Weber, L. M.; Samartsidis, P.; Robinson, M. D.
10.1101/2020.11.24.394213 — bioinformatics — Posted on 2021-05-06
3801 DeepImageJ: A user-friendly environment to run deep learning models in ImageJ
Gomez-de-Mariscal, E.; Garcia-Lopez-de-Haro, C.; Ouyang, W.; Donati, L.; Lundberg, E.; Unser, M.; Munoz-Barrutia, A.; Sage, D.
10.1101/799270 — bioengineering — Posted on 2021-05-06
3804 A spoonful of disorder regulates interactions within Stress Granules and Processing Bodies
Vandelli, A.; Samper, F. C.; Torrent Burgas, M.; Sanchez de Groot, N.; Tartaglia, G. G.
10.1101/2021.05.05.442738 — molecular biology — Posted on 2021-05-06
3805 CLAMP and Zelda function together to promote Drosophila zygotic genome activation
Duan, J. E.; Rieder, L.; Colonnetta, M. M.; Huang, A.; Mckenney, M.; Watters, S.; Deshpande, G.; Jordan, W.; Fawzi, N. L.; Larschan, E.
10.1101/2020.07.15.205054 — genomics — Posted on 2021-05-05
3806 A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma
Gonzalez-Rajal, A.; Marzec, K.; McCloy, R. A.; Nobis, M.; Chin, V.; Hastings, J. F.; Lai, K.; Kennerson, M.; Hughes, W. E.; Vaghjiani, V.; Timpson, P.; Cain, J.; Watkins, D. N.; Croucher, D. R.; Burgess, A.
10.1101/2020.11.26.400499 — cell biology — Posted on 2021-05-05
3807 MG53 slows neuromuscular junction loss and prolongs survival in ALS
Yi, J.; Li, A.; Li, X.; Park, K. H.; Zhou, X.; Yi, F.; Xiao, Y.; Yoon, D.; Tan, T.; Ostrow, L. W.; Ma, J.; Zhou, J.
10.1101/2021.04.22.441038 — cell biology — Posted on 2021-05-05
3808 Flexible neural control of motor units
Marshall, N. J.; Glaser, J. I.; Trautmann, E. M.; Amematsro, E. A.; Perkins, S. M.; Shadlen, M. N.; Abbott, L. F.; Cunningham, J. P.; Churchland, M. M.
10.1101/2021.05.05.442653 — neuroscience — Posted on 2021-05-05
3814 Visualization of ecological successions in lakes subdivided by volcanic eruption at Akan Caldera, Hokkaido, Japan
Wakana, I.; Kadono, Y.; Urabe, J.; Tamura, Y.; Suzuki, Y.; Yamada, H.; Oyama, Y.; Wada, K.; Hasegawa, T.; Ohara, M.
10.1101/2021.05.05.442726 — ecology — Posted on 2021-05-05
3817 Telomeric 8-oxoguanine drives rapid premature senescence in the absence of telomere shortening
Barnes, R. P.; de Rosa, M.; Thosar, S. A.; Detwiler, A. C.; Roginskaya, V.; Van Houten, B.; Bruchez, M. P.; Stewart-Ornstein, J.; Opresko, P. L.
10.1101/2021.05.05.442662 — molecular biology — Posted on 2021-05-05
3821 Heme oxygenase limits mycobacterial infection-induced ferroptosis
Luo, K.; Stocker, R.; Britton, W. J.; Kikuchi, K.; Oehlers, S. H.
10.1101/2021.05.04.442683 — immunology — Posted on 2021-05-05
3823 MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline
Moon, J.; Bremer, P.-T.; Mukherjee, P.; Markowitz, A. J.; Palacios, E. M.; Cai, L. T.; Rodriguez, A.; Xiao, Y.; Manley, G. T.; Madduri, R.
10.1101/2020.12.23.424191 — neuroscience — Posted on 2021-05-05
3831 A statistical test for clonal exclusivity in tumour evolution
Kuipers, J.; Moore, A. L.; Jahn, K.; Schraml, P.; Wang, F.; Morita, K.; Futreal, A.; Takahashi, K.; Beisel, C.; Moch, H.; Beerenwinkel, N.
10.1101/2021.05.05.442732 — cancer biology — Posted on 2021-05-05
3832 Designing Novel and Potent Inhibitors for Multi Drug-Resistant Tuberculosis: A Computational Approach
Idrees, M.; Ahmad, B.; Israr, M.; Waqas, M.; Mukarram Shah, S. M.; Khattak, A.; Khan, S. A.
10.1101/2021.05.05.442727 — bioinformatics — Posted on 2021-05-05
3835 Fusion protein EWS-FLI1 is incorporated into a protein granule in cells
Ahmed, N. S.; Harrell, L. M.; Wieland, D. R.; Lay, M. A.; Thompson, V. F.; Schwartz, J. C.
10.1101/2020.05.31.122028 — biochemistry — Posted on 2021-05-05
3838 Dog10K_Boxer_Tasha_1.0: A long-read assembly of the dog reference genome
jagannathan, v.; HITTE, C.; Kidd, J. M.; Materson, p.; Murphy, T. D.; Emery, S.; Davis, B. W.; Buckley, R. M.; Liu, Y.; Zhang, X.; Leeb, T.; Zhang, Y.-p.; Ostrander, E. A.; Wang, G.-D.
10.1101/2021.05.05.442772 — genomics — Posted on 2021-05-05
3840 Thermal tolerance and preference are both consistent with the clinal distribution of house fly proto-Y chromosomes
Delclos, P. J.; Adhikari, K.; Hassan, O.; Cambric, J. E.; Matuk, A. G.; Presley, R. I.; Tran, J.; Sriskantharajah, V.; Meisel, R. P.
10.1101/2021.01.14.426736 — evolutionary biology — Posted on 2021-05-05
3844 The CPEB3 ribozyme modulates hippocampal-dependent memory
Chen, C. C.; Han, J.; Chinn, C. A.; Li, X.; Nikan, M.; Myszka, M.; Tong, L.; Bredy, T. W.; Wood, M. A.; Luptak, A.
10.1101/2021.01.23.426448 — molecular biology — Posted on 2021-05-05
3845 Population analysis of Vibrio cholerae in aquatic reservoirs reveals a novel sister species (Vibrio paracholerae sp. nov.) with a history of association with human infections
Islam, M. T.; Nasreen, T.; Kirchberger, P.; Liang, K. Y. H.; Orata, F. D.; Johura, F.-T.; Im, M. S.; Tarr, C. L.; Alam, M.; Boucher, Y. F.
10.1101/2021.05.05.442690 — microbiology — Posted on 2021-05-05
3849 The tunicate metabolite 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine targets ion channels of vertebrate sensory neurons
Paguigan, N. D.; Yan, Y.; Karthikeyan, M.; Chase, K.; Carter, J.; Leavitt, L. S.; Lim, A. L.; Lin, Z.; Memon, T.; Christensen, S. B.; Bentzen, B. H.; Schmitt, N.; Reilly, C. A.; Teichert, R. W.; Raghuraman, S.; Olivera, B. M.; Schmidt, E. W.
10.1101/2021.05.05.442828 — neuroscience — Posted on 2021-05-05
3851 Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects cognitive behavior
Fang, L.; Zhao, N.; Caudal, L.; Zhao, R.; Lin, C.-H.; Chang, H.-F.; Hainz, N.; Meier, C.; Bettler, B.; Huang, W.; Scheller, A.; Kirchhoff, F.; Bai, X.
10.1101/2021.05.04.442422 — neuroscience — Posted on 2021-05-05
3853 A Kink in DWORF Helical Structure Controls the Activation of the Sarco-plasmic Reticulum Ca2+-ATPase
Reddy, V. U.; Weber, D. K.; Wang, S.; Larsen, E. K.; Gopinath, T.; De Simone, A.; Robia, S. L.; Veglia, G.
10.1101/2021.05.05.442831 — biophysics — Posted on 2021-05-05
3857 Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
Rasmussen, E. M. K.; Seier, K. L.; Pedersen, I. K.; Kreibich, C.; Amdam, G. V.; Münch, D.; Dahl, J. A.
10.1101/2021.05.05.442791 — genomics — Posted on 2021-05-05
3858 A high-continuity and annotated tomato reference genome
Su, X.; Wang, B.; Geng, X.; Du, Y.; Yang, Q.; Liang, B.; Meng, G.; Gao, Q.; Huang, S.; Yang, W.; Zhu, Y.; Lin, T.
10.1101/2021.05.04.441887 — genomics — Posted on 2021-05-05
3859 Amino acid sensor conserved from bacteria to humans
Gumerov, V. M.; Andrianova, E. P.; Matilla, M. A.; Dolphin, A. C.; Krell, T.; Zhulin, I. B.
10.1101/2021.05.05.442820 — evolutionary biology — Posted on 2021-05-05
3864 The Internal Structure of Metacommunities
Leibold, M. A.; Rudolf, J.; Blanchet, F. G.; De Meester, L.; Gravel, D.; Hartig, F.; Peres-Neto, P.; Shoemaker, L.; Chase, J.
10.1101/2020.07.04.187955 — ecology — Posted on 2021-05-05
3867 Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants
Iwakawa, H.-o.; Lam, A. Y. W.; Mine, A.; Fujita, T.; Kiyokawa, K.; Yoshikawa, M.; Takeda, A.; Iwasaki, S.; Tomari, Y.
10.1101/2020.09.10.288902 — molecular biology — Posted on 2021-05-05
3868 Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant
Yinda, K. C.; Port, J.; Bushmaker, T.; Fischer, R.; Schulz, J.; Holbrook, M.; Shaia, C.; de Wit, E.; van Doremalen, N.; Munster, V.
10.1101/2021.05.05.442780 — microbiology — Posted on 2021-05-05
3870 The CTPase activity of ParB acts as a timing mechanism to control the dynamics and function of prokaryotic DNA partition complexes
Osorio-Valeriano, M.; Altegoer, F.; Das, C. K.; Steinchen, W.; Panis, G.; Connolley, L.; Giacomelli, G.; Feddersen, H.; Corrales-Guerrero, L.; Giammarinaro, P.; Hanssmann, J.; Bramkamp, M.; Viollier, P. H.; Murray, S.; Schäfer, L. V.; Bange, G.; Thanbichler, M.
10.1101/2021.05.05.442810 — microbiology — Posted on 2021-05-05
3871 SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant
Yadav, P. D.; Mohandas, S.; Shete, A. M.; Nyayanit, D. A.; Gupta, N.; Patil, D. Y.; Sapkal, G. N.; Potdar, V.; Kadam, M.; kumar, A.; Kumar, S.; Suryavanshi, D.; Mote, C. S.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.05.05.442760 — microbiology — Posted on 2021-05-05
3873 Temporal dynamics of implicit memory underlying serial dependence
Bilacchi, C. M.; Sirius, E. V. P.; Cravo, A. M.; de Azevedo Neto, R. M.
10.1101/2020.11.17.386821 — neuroscience — Posted on 2021-05-05
3875 Single-nuclei transcriptomics of schizophrenia prefrontal cortex primarily implicates neuronal subtypes
Reiner, B. C.; Crist, R. C.; Stein, L. M.; Weller, A. E.; Doyle, G. A.; Arauco-Shapiro, G.; Turecki, G.; Ferraro, T. N.; Hayes, M. R.; Berrettini, W. H.
10.1101/2020.07.29.227355 — neuroscience — Posted on 2021-05-05
3879 ProLung™-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation
Konduri, K. S.; Pattisapu, R.; Pattisapu, J.; Konduri, G. G.; Zwetchkenbaum, J.; Roy, B.; Barman, M.; Frazier, A.; Hurst, B. L.; Duzgunes, N.
10.1101/2021.05.05.442779 — pharmacology and toxicology — Posted on 2021-05-05
3881 The genomic landscape of early stage ovarian high grade serous carcinoma
Cheng, Z.; Mirza, H.; Ennis, D. P.; Smith, P.; Morrill, L.; Sokota, C.; Giannone, G.; Goranova, T.; Bradley, T.; Piskorz, A.; Lockley, M.; The BriTROC Investigators, ; Kaur, B.; Singh, N.; Tookman, L.; Krell, J.; McDermott, J.; Macintyre, G.; Markowetz, F.; Brenton, J.; McNeish, I.
10.1101/2021.05.05.440631 — cancer biology — Posted on 2021-05-05
3885 Temperature-dependent effects of house fly proto-Y chromosomes on gene expression
Adhikari, K.; Son, J. H.; Rensink, A. H.; Jaweria, J.; Bopp, D.; Beukeboom, L.; Meisel, R. P.
10.1101/2020.08.05.238378 — evolutionary biology — Posted on 2021-05-05
3887 Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes
Lancaster, C.; Fountain, A.; Dayam, R.; Somerville, E.; Sheth, J.; Jacobelli, V.; Somerville, A.; Terebiznik, M.; Botelho, R. J.
10.1101/2020.05.14.094722 — cell biology — Posted on 2021-05-05
3889 Ssl2/TFIIH Function in Transcription Start Site Scanning by RNA Polymerase II in Saccharomyces cerevisiae
Zhao, T.; Vvedenskaya, I. O.; Lai, W. K. M.; Basu, S.; Pugh, B. F.; Nickels, B. E.; Kaplan, C. D.
10.1101/2021.05.05.442816 — molecular biology — Posted on 2021-05-05
3891 Thiolutin is a direct inhibitor of RNA Polymerase II
Qiu, C.; Malik, I.; Arora, P.; Laperuta, A. J.; Pavlovic, E. M.; Ugochuckwu, S.; Naik, M. T.; Kaplan, C. D.
10.1101/2021.05.05.442806 — molecular biology — Posted on 2021-05-05
3894 Combination Respiratory Vaccine Containing Recombinant SARS-CoV-2 Spike and QuadrivalentSeasonal Influenza Hemagglutinin Nanoparticles with Matrix-M Adjuvant
Massare, M. J.; Patel, N.; Zhou, B.; Maciejewski, S.; Flores, R.; Guebre-Xabier, M.; Tian, J.-H.; Portnoff, A. D.; Fries, L.; Shinde, V.; Ellingsworth, L. R.; Glenn, G.; Smith, G.
10.1101/2021.05.05.442782 — immunology — Posted on 2021-05-05
3895 Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids
Dekkers, J. F.; Alieva, M.; Cleven, A.; Keramati, F.; Brazda, P.; Rebel, H. G.; Wezenaar, A. K. L.; Puschhof, J.; Buchholz, M.-B.; Barrera Roman, M.; Johanna, I.; Meringa, A. D.; Fasci, D.; Geurts, M. H.; Ariese, H. C. R.; van Vliet, E. J.; van Ineveld, R. L.; Karaiskaki, E.; Kopper, O.; Bar-Ephraim, Y. E.; Kretzschmar, K.; Eggermont, A. M. M.; Wehrens, E. J.; Stunnenberg, H. G.; Clevers, H.; Kuball, J.; Sebestyen, Z.; Rios, A. C.
10.1101/2021.05.05.442764 — cancer biology — Posted on 2021-05-05
3897 Genetic determinism of phage-bacteria coevolution in natural populations
Piel, D.; Bruto, M.; Labreuche, Y.; Blanquart, F.; Chenivesse, S.; Lepanse, S.; James, A.; Barcia Cruz, R.; Dubert, J.; Petton, B.; Lieberman, E.; Wegner, M.; Hussain, F.; Kauffman, K.; Polz, M.; Bikard, D.; Gandon, S.; Le Roux, F.
10.1101/2021.05.05.442762 — microbiology — Posted on 2021-05-05
3898 SAMase of bacteriophage T3 inactivates E. coli methionine S-adenosyltransferase by forming hetero-polymers
Simon-Baram, H.; Kleiner, D.; Shmulevich, F.; Zarivach, R.; Zalk, R.; Tang, H.; Ding, F.; Bershtein, S.
10.1101/2021.05.05.442785 — microbiology — Posted on 2021-05-05
3900 SARS-CoV-2 variant B.1.617 is resistant to Bamlanivimab and evades antibodies induced by infection and vaccination
Hoffmann, M.; Hofmann-Winkler, H.; Krueger, N.; Kempf, A.; Nehlmeier, I.; Graichen, L.; Sidarovich, A.; Moldenhauer, A.-S.; Winkler, M. S.; Schulz, S.; Jaeck, H.-M.; Stankov, M. V.; Behrens, G. M. N.; Poehlmann, S.
10.1101/2021.05.04.442663 — molecular biology — Posted on 2021-05-05
3901 SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy
Horspool, A. M.; Ye, C.; Wong, T. Y.; Russ, B. P.; Lee, K. S.; Winters, M. T.; Bevere, J. R.; Kieffer, T.; Martinez, I.; Sourimant, J.; Greninger, A. L.; Plemper, R. K.; Denvir, J.; Cyphert, H. A.; Torrelles, J. B.; Martinez-Sobrido, L.; Damron, F. H.
10.1101/2021.05.05.442784 — microbiology — Posted on 2021-05-05
3903 Durable antibody responses in staff at two long-term care facilities, during and post SARS-CoV-2 outbreaks
Gallichotte, E.; Nehring, M.; Young, M. C.; Pugh, S.; Sexton, N. R.; Fitzmeyer, E.; Quicke, K. M.; Richardson, M.; Pabilonia, K. L.; Ehrhart, N.; VandeWoude, S.; Ebel, G. D.
10.1101/2021.05.04.442699 — immunology — Posted on 2021-05-05
3904 Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein
Zuzic, L.; Samsudin, F.; Shivgan, A. T.; Raghuvamsi, P. V.; Marzinek, J. K.; Boags, A.; Pedebos, C.; Tulsian, N. K.; Warwicker, J.; MacAry, P.; Crispin, M.; Khalid, S.; Anand, G. S.; Bond, P. J.
10.1101/2021.05.05.442536 — biophysics — Posted on 2021-05-05
3905 Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19
Tindle, C.; Fuller, M.; Fonseca, A.; Taheri, S.; Ibeawuchi, S.-R.; Beutler, N.; Katkar, G.; Claire, A.; Castillo, V.; Hernandez, M.; Russo, H.; Duran, J.; Crotty Alexander, L. E.; Tipps, A.; Lin, G.; Thistlethwaite, P. A.; Chattopadhyay, R.; Rogers, T. F.; Sahoo, D.; Ghosh, P.; Das, S.
10.1101/2020.10.17.344002 — cell biology — Posted on 2021-05-05
3906 Development of a novel hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening and quantification of neutralization antibodies, viral variants, and antiviral drugs
Hetrick, B.; He, S.; Chilin, L. D.; Dabbagh, D.; Alem, F.; Narayanan, A.; Luchini, A.; Li, T.; Liu, X.; Copeland, J.; Pak, A.; Cunningham, T.; Liotta, L.; Petricoin, E.; Andalibi, A.; Wu, Y.
10.1101/2020.12.22.423965 — microbiology — Posted on 2021-05-05
3907 Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants
Zhang, Y.-N.; Paynter, J.; Sou, C.; Fourfouris, T.; Wang, Y.; Abraham, C.; Ngo, T.; Zhang, Y.; He, L.; Zhu, J.
10.1101/2021.03.26.437274 — immunology — Posted on 2021-05-05
3909 Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice
Carter, B.; Chen, J.; Kaseke, C.; Dimitrakakis, A.; Gaiha, G. D.; Xu, Q.; Gifford, D. K.
10.1101/2021.05.02.442052 — immunology — Posted on 2021-05-05
3911 SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques
Philippens, I. H. C. H. M.; Boszormenyi, K. P.; Wubben, J. A.; Fagrouch, Z. C.; van Driel, N.; Mayenburg, A. Q.; Lozovagia, D.; Roos, E.; Schurink, B.; Bugiani, M.; Bontrop, R. E.; Middeldorp, J.; Bogers, W. M.; de Geus-Oei, L.-F.; Langermans, J. A. M.; Stammes, M. A.; Verstrepen, B. E.; Verschoor, E. J.
10.1101/2021.02.23.432474 — neuroscience — Posted on 2021-05-05
3912 Neural Fragility as an EEG Marker of the Seizure Onset Zone
Li, A.; Huynh, C.; Fitzgerald, Z.; Cajigas, I.; Brusko, D.; Claudio, A.; Jagid, J.; Kanner, A.; Hopp, J.; Chen, S.; Haagensen, J.; Johnson, E.; Crone, N.; Anderson, W.; Inati, S.; Zaghloul, K.; Bulacio, J.; Martinez, J.; Sarma, S.
10.1101/862797 — neuroscience — Posted on 2021-05-05
3913 Whole-genome duplication shapes the aneuploidy landscape of human cancers
Prasad, K.; Bloomfield, M.; Levi, H.; Keuper, K.; Bernhard, S. V.; Baudoin, N. C.; Leor, G.; Giam, M.; Wong, C. K.; Rancati, G.; Storchova, Z.; Cimini, D.; Ben-David, U.
10.1101/2021.05.05.442712 — cancer biology — Posted on 2021-05-05
3917 Mapping the microbial diversity and natural resistome of north Antarctica soils
Marcoleta, A. E.; Varas, M. A.; Costa, J.; Rojas-Salgado, J.; Arros, P.; Berrios Pasten, C.; Tapia, S.; Silva, D.; Fierro, J.; Canales, N.; Chavez, F. P.; Gaete, A.; Gonzalez, M.; Allende, M. L.; Lagos, R.
10.1101/2021.05.05.442734 — microbiology — Posted on 2021-05-05
3918 Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model
Tsai, C.-Y.; Chou, Y.-C.; Chen, C.-Y.; Jan, J.-T.; Chang, M.-L.; Lu, L.-A.; Huang, P.-Y.; Chu, M. F.- C.; Hsu, T.-T.; Hsueh, Y.-P.
10.1101/2021.05.04.441029 — microbiology — Posted on 2021-05-05
3921 TISON: a next-generation multi-scale modeling theatre for in silico systems oncology
Gondal, M. N.; Sultan, M. U.; Arif, A.; Rehman, A.; Awan, H. A.; Arshad, Z.; Ahmed, W.; Chaudhary, M. F.; Khan, S.; Tanveer, Z. B.; Butt, R. N.; Hussain, R.; Khawar, H.; Amina, B.; Akbar, R.; Abbas, F.; Jami, M. N.; Nasir, Z.; Shah, O. S.; Hameed, H.; Butt, M. F.; Mustafa, G.; Ahmad, M. M.; Ahmed, S.; Qazi, R.; Ahmed, F.; Ishaq, O.; Nabi, S. W.; Vanderbauwhede, W.; Wajid, B.; Shehwana, H.; Uddin, E.; Safdar, M.; Javed, I.; Tariq, M.; Faisal, A.; Chaudhary, S. U.
10.1101/2021.05.04.442539 — systems biology — Posted on 2021-05-05
3922 Probing the biogenesis pathway and dynamics of thylakoid membranes
Huokko, T.; Ni, T.; Dykes, G.; Simpson, D.; Brownridge, P.; Conradi, F.; Beynon, R.; Nixon, P.; Mullineaux, C.; Zhang, P.; Liu, L.-N.
10.1101/2021.05.05.442711 — plant biology — Posted on 2021-05-05
3925 Chronic Aryl Hydrocarbon Receptor Activity Phenocopies Smoking-induced Skeletal Muscle Impairment
Thome, T.; Miguez, K.; Willms, A.; Fitzgerald, L.; Burke, S. S.; Chandran, V.; de Souza, A. R.; Baglole, C.; Anagnostou, M.-E.; Bourbeau, J.; Jagoe, R. T.; Morais, J. A.; Goddard, Y.; Taivassalo, T.; Ryan, T. E.; Hepple, R. T.
10.1101/2021.05.05.441943 — physiology — Posted on 2021-05-05
3933 Cancer mutational processes vary in their association with replication timing and chromatin accessibility
Yaacov, A.; Vardi, O.; Blumenfeld, B.; Greenberg, A.; Massey, D. J.; Koren, A.; Adar, S.; Simon, I.; Rosenberg, S.
10.1101/2021.05.05.442736 — genomics — Posted on 2021-05-05
3935 Inbreeding reduces fitness of seed beetles under thermal stress
Ivimey-Cook, E. R.; Bricout, S.; Candela, V.; Maklakov, A. A.; Berg, E. C.
10.1101/2021.05.05.442709 — evolutionary biology — Posted on 2021-05-05
3936 Adaptive foraging behaviour increases vulnerability to climate change
Gauzens, B.; Rosenbaum, B.; Kalinkat, G.; Boy, T.; Jochum, M.; Kortsch, S.; O'Gorman, E. J.; Brose, U.
10.1101/2021.05.05.442768 — ecology — Posted on 2021-05-05
3938 Protective mitochondrial fission induced by stress responsive protein GJA1-20k
Shimura, D.; Nuebel, E.; Baum, R.; Xiao, S.; Warren, J. S.; Hong, T.; Rutter, J.; Shaw, R. M.
10.1101/2021.05.05.442750 — cell biology — Posted on 2021-05-05
3940 A spoonful of disorder regulates interactions within Stress Granules and Processing Bodies
Vandelli, A.; Samper, F. C.; Torrent Burgas, M.; Sanchez de Groot, N.; Tartaglia, G. G.
10.1101/2021.05.05.442738 — molecular biology — Posted on 2021-05-05
3941 The dengue virus NS1 protein conveys pro-inflammatory signals by docking onto human high-density lipoproteins
Benfrid, S.; Park, K.-H. P.; Dellarole, M.; Voss, J. E.; Tamietti, C.; Pehau-Arnaudet, G.; Raynal, B.; Brule, S.; England, P.; Zhang, X.; Mikhailova, A.; Ungeheuer, M.-N.; Petres, S.; Biering, S.; Harris, E.; Sakuntabhai, A.; Buchy, P.; Duong, V.; Dussart, P.; Coulibaly, F.; Bontems, F.; Rey, F. A.; Flamand, M.
10.1101/2021.05.05.442454 — microbiology — Posted on 2021-05-05
3943 Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells
Pagani, I.; Ottoboni, L.; Podini, P.; Ghezzi, S.; Brambilla, E.; Bezukladova, S.; Corti, D.; Bianchi, M. E.; Capobianchi, M. R.; Yates, E. A.; Martino, G.; Vicenzi, E.
10.1101/2021.05.05.442746 — microbiology — Posted on 2021-05-05
3944 Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish
Odstrcil, I.; Petkova, M. D.; Haesemeyer, M.; Boulanger-Weill, J.; Nikitchenko, M.; Gagnon, J. A.; Oteiza, P.; Schalek, R.; Peleg, A.; Portugues, R.; Lichtman, J.; Engert, E.
10.1101/2021.05.04.442674 — neuroscience — Posted on 2021-05-05
3945 Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain
Meier, J.; Perdikis, D.; Blickensdörfer, A.; Stefanovski, L.; Liu, Q.; Maith, O.; Dinkelbach, H. U.; Baladron, J.; Hamker, F. H.; Ritter, P.
10.1101/2021.05.05.442704 — neuroscience — Posted on 2021-05-05
3946 Metamodal Coupling of Vibrotactile and Auditory Speech Processing Systems Through Matched Stimulus Representations
Damera, S. R.; Malone, P.; Stevens, B.; Klein, R.; Eberhardt, S. P.; Auer, E. T.; Bernstein, L. E.; Riesenhuber, M.
10.1101/2021.05.04.442660 — neuroscience — Posted on 2021-05-05
3950 Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: The Replica Project
Caruso, M.; Emma, R.; Distefano, A.; Rust, S.; Poulas, K.; Zadjali, F.; Boffo, S.; Volarevic, V.; Mesiakaris, K.; Al Tobi, M.; Giordano, A.; Arsenijevic, A.; Zuccarello, P.; Ferrante, M.; Polosa, R.; Li Volti, G.; Replica Project Group,
10.1101/2021.05.05.442767 — pharmacology and toxicology — Posted on 2021-05-05
3951 Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
Knight, J. R.; Vlahov, N.; Gay, D. M.; Ridgway, R. A.; Faller, L.; Proud, C.; Mallucci, G. R.; von der Haar, T.; Smales, C. M.; Willis, A. E.; Sansom, O. J.
10.1101/2021.05.05.442715 — cancer biology — Posted on 2021-05-05
3953 Explainable Sleep Stage Classification with Multimodal Electrophysiology Time-series
Ellis, C. A.; Zhang, R.; Carbajal, D. A.; Miller, R. L.; Calhoun, V. A.; Wang, M. D.
10.1101/2021.05.04.442658 — bioinformatics — Posted on 2021-05-05
3955 Adolescent Alcohol Binge-Drinking induces delayed appearance of behavioral defects in mice
Van Hees, L.; Didone, V.; Charlet-Briart, M.; Van Ingelgom, T.; Alexandre, A.; Quertemont, E.; Nguyen, L.; Laguesse, S.
10.1101/2020.08.11.245878 — animal behavior and cognition — Posted on 2021-05-05
3957 Trophic niche of the invasive gregarious species Crepidula fornicata, in relation to ontogenic changes
Androuin, T.; Dubois, S. F.; Hubas, C.; Lefebvre, G.; Le Grand, F.; Schaal, G.; Carlier, A.
10.1101/2020.07.30.229021 — ecology — Posted on 2021-05-05
3958 Clumpy coexistence in phytoplankton: The role of functional similarity in community assembly
Graco-Roza, C.; Segura, A. M.; Kruk, C.; Domingos, P.; Soininen, J.; Marinho, M. M.
10.1101/869966 — ecology — Posted on 2021-05-05
3961 In-situ observation of mitochondrial biogenesis as the early event of apoptosis
Shao, C.-s.; Zhou, X.-H.; Miao, Y.-H.; Wang, P.; Zhang, Q.-q.; Huang, Q.
10.1101/2020.08.23.263152 — cell biology — Posted on 2021-05-05
3963 Transcriptomic and rRNA:rDNA signatures of environmental vs. enteric Enterococcus faecalis isolates under oligotrophic freshwater conditions
Suttner, B.; Kim, M.; Johnston, E. R.; Orellana, L.; Ruiz-Perez, C. A.; Rodriguez-R, L. M.; Hatt, J.; Brown, J.; Santo Domingo, J. W.; Konstantinidis, K. T.
10.1101/2021.05.04.442698 — microbiology — Posted on 2021-05-05
3965 A CTP-dependent gating mechanism enables ParB spreading on DNA in Caulobacter crescentus
Jalal, A. S. B.; Tran, N. T.; Stevenson, C. E. M.; Chimthanawala, A.; Badrinarayanan, A.; Lawson, D. M.; Le, T. B. K.
10.1101/816959 — microbiology — Posted on 2021-05-05
3966 pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread
Benedyk, T. H.; Muenzner, J.; Connor, V.; Han, Y.; Brown, K.; Wijesinghe, K. J.; Zhuang, Y.; Colaco, S.; Stoll, G. A.; Tutt, O. S.; Svobodova, S.; Svergun, D. I.; Bryant, N. A.; Deane, J. E.; Firth, A. E.; Jeffries, C. M.; Crump, C. M.; Graham, S. C.
10.1101/2021.04.13.439638 — microbiology — Posted on 2021-05-05
3967 Strategic infarct locations for post-stroke depressive symptoms: a lesion- and disconnection-symptom mapping study
Weaver, N. A.; Lim, J.-S.; Schilderinck, J.; Biessels, G. J.; Kang, Y.; Kim, B. J.; Kuijf, H. J.; Lee, B.-C.; Lee, K.-J.; Yu, K.-H.; Bae, H.-J.; Biesbroek, J. M.
10.1101/2021.05.05.442398 — neuroscience — Posted on 2021-05-05
3968 A Discriminative Characterization of Heschl's Gyrus Morphology using Spectral Graph Features
Maghsadhagh, S.; Dalboni da Rocha, J. L.; Benner, J.; Schneider, P.; Golestani, N.; Behjat, H.
10.1101/2021.05.04.442618 — neuroscience — Posted on 2021-05-05
3970 Autonomic arousals contribute to brain fluid pulsations during sleep
Picchioni, D.; Ozbay, P. S.; Mandelkow, H.; de Zwart, J. A.; Wang, Y.; van Gelderen, P.; Duyn, J. H.
10.1101/2021.05.04.442672 — neuroscience — Posted on 2021-05-05
3972 Functional architecture of neural circuits for leg proprioception in Drosophila
Chen, C.; Agrawal, S.; Mark, B.; Mamiya, A.; Sustar, A.; Phelps, J. S.; Lee, W.-C. A.; Dickson, B. J.; Card, G. M.; Tuthill, J. C.
10.1101/2021.05.04.442472 — neuroscience — Posted on 2021-05-05
3973 Can you affect me? The influence of vitality forms on action perception and motor response
Lombardi, G.; Zenzeri, J.; Belgiovine, G.; Vannucci, F.; Rea, F.; Sciutti, A.; Di Cesare, G.
10.1101/2021.05.04.442561 — neuroscience — Posted on 2021-05-05
3974 BigBrainWarp: Toolbox for integration of BigBrain 3D histology with mutlimodal neuroimaging
Paquola, C.; Royer, J.; Lewis, L. B.; Lepage, C.; Glatard, T.; Wagstyl, K.; DeKraker, J.; Toussaint, P.-J.; Valk, S. L.; Collins, D. L.; Khan, A.; Amunts, K.; Evans, A. C.; Dickscheid, T.; Bernhardt, B.
10.1101/2021.05.04.442563 — neuroscience — Posted on 2021-05-05
3976 Conserved organ-specific microbial assemblages in different populations of a terrestrial crab
Bacci, G.; Fratini, S.; Meriggi, N.; Cheng, C. L. Y.; Ng, K. H.; Pindo, M.; Iannucci, A.; Mengoni, A.; Cavalieri, D.; Cannicci, S.
10.1101/2021.03.30.437674 — zoology — Posted on 2021-05-05
3978 Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni
Rawlinson, K. A.; Reid, A. J.; Lu, Z.; Driguez, P.; Wawer, A.; Coghlan, A.; Sankaranarayanan, G.; Buddenborg, S. K.; Diaz-Soria, C. L.; McCarthy, C.; Holroyd, N.; Sanders, M.; Hoffmann, K.; Wilcockson, D.; Rinaldi, G.; Berriman, M.
10.1101/2021.04.21.440693 — systems biology — Posted on 2021-05-05
3979 Fitting side-chain NMR relaxation data using molecular simulations
Kümmerer, F.; Orioli, S.; Harding-Larsen, D.; Hoffmann, F.; Gavrilov, Y.; Teilum, K.; Lindorff-Larsen, K.
10.1101/2020.08.18.256024 — biophysics — Posted on 2021-05-05
3980 Biological mechanisms of aging predict age-related disease multimorbidities in patients
Fraser, H. C.; Kuan, V.; Johnen, R.; Zwierzyna, M.; Hingorani, A. D.; Beyer, A.; Partridge, L.
10.1101/2021.05.04.442567 — bioinformatics — Posted on 2021-05-05
3981 Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma
Panda, S. K.; Tan, R. K. Y.; Tun, T. A.; Buist, M. L.; Nongpiur, M.; Baskaran, M.; Aung, T.; Girard, M. J. A.
10.1101/2021.05.04.442554 — bioengineering — Posted on 2021-05-05
3984 Metabarcoding and ecological interaction networks for selecting candidate biological control agents
Ollivier, M.; Lesieur, V.; Tavoillot, J.; Benetiere, F.; Martin, J.-F.; Tixier, M. S.
10.1101/2021.05.04.442560 — ecology — Posted on 2021-05-05
3987 Neural Fragility as an EEG Marker of the Seizure Onset Zone
Li, A.; Huynh, C.; Fitzgerald, Z.; Cajigas, I.; Brusko, D.; Claudio, A.; Jagid, J.; Kanner, A.; Hopp, J.; Chen, S.; Haagensen, J.; Johnson, E.; Crone, N.; Anderson, W.; Inati, S.; Zaghloul, K.; Bulacio, J.; Martinez, J.; Sarma, S.
10.1101/862797 — neuroscience — Posted on 2021-05-05
3993 The genome of the cereal pest Sitophilus oryzae: a transposable element haven
Parisot, N.; Vargas-Chavez, C.; Goubert, C.; Baa-Puyoulet, P.; Balmand, S.; Beranger, L.; Blanc, C.; Bonnamour, A.; Boulesteix, M.; Burlet, N.; Calevro, F.; Callaerts, P.; Chancy, T.; Charles, H.; Colella, S.; Da Silva Barbosa, A.; Dell'Aglio, E.; Di Genova, A.; Febvay, G.; Gabaldon, T.; Galvao Ferrarini, M.; Gerber, A.; Gillet, B.; Hubley, R.; Hughes, S.; Jacquin-Joly, E.; Maire, J.; Marcet-Houben, M.; Masson, F.; Meslin, C.; Montagne, N.; Moya, A.; Ribeiro de Vasconcelos, A. T.; Richard, G.; Rosen, J.; Sagot, M.-F.; Smit, A. F.; Storer, J.; Vincent-Monegat, C.; Vallier, A.; Vigneron, A.; Zai
10.1101/2021.03.03.408021 — genomics — Posted on 2021-05-05
3995 Bacterial surface properties influence the activity of the TAT-RasGAP317-326 antimicrobial peptide
Georgieva, M.; Heinonen, T.; Vitale, A.; Hargraves, S.; Causevic, S.; Pillonel, T.; Eberl, L.; Widmann, C.; Jacquier, N.
10.1101/2020.10.02.321802 — microbiology — Posted on 2021-05-05
3998 Capacity to erase gene occlusion is a defining feature distinguishing naive from primed pluripotency
Foshay, K. M.; Lee, J. H.; Zhang, L.; Fernandes, C. J.; Wu, B.; Gaetz, J.; Baker, S. W.; Looney, T. J.; Xiang, A. P.; Fan, G.; Lahn, B. T.
10.1101/2021.05.04.442547 — molecular biology — Posted on 2021-05-04
4001 Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1
Carozza, J. A.; Cordova, A. F.; AlSaif, Y.; Böhnert, V.; Skariah, G.; Li, L.
10.1101/2021.05.04.442665 — immunology — Posted on 2021-05-04
4003 Single-cell gene regulatory network inference atscale: The Inferelator 3.0
Skok Gibbs, C.; Jackson, C. A.; Saldi, G.-A.; Shah, A.; Tjärnberg, A.; Watters, A.; De Veaux, N.; Tchourine, K.; Yi, R.; Hamamsy, T.; Castro, D. M.; Carriero, N.; Gresham, D.; Miraldi, E. R.; Bonneau, R.
10.1101/2021.05.03.442499 — systems biology — Posted on 2021-05-04
4004 Visualization of Arabidopsis root system architecture in 3D by refraction-contrast X-ray micro-computed tomography
Kurogane, T.; Tamaoki, D.; Yano, S.; Tanigaki, F.; Shimazu, T.; Kasahara, H.; Yamauchi, D.; Uesugi, K.; Hoshino, M.; Kamisaka, S.; Mineyuki, Y.; Karahara, I.
10.1101/2021.05.04.442685 — plant biology — Posted on 2021-05-04
4005 Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner
Wakefield, C. B.; Lee, V. R.; Johnston, D.; Boroumand, P.; Pillon, N. J.; Sayedyahossein, S.; Sanchez-Pupo, R. E.; Barr, K. J.; Gros, R.; Borradaile, N.; Klip, A.; Beier, F.; Penuela, S.
10.1101/2021.05.04.442670 — physiology — Posted on 2021-05-04
4008 Population genomics of Pocillopora corals: insights from RAD-sequencing
Aurelle, D.; Pratlong, M.; Oury, N.; Haguenauer, A.; Gelin, P.; Magalon, H.; Adjeroud, M.; Romans, P.; Vidal-Dupiol, J.; Claereboudt, M.; Nous, C.; Reynes, L.; Toulza, E.; Bonhomme, F.; Mitta, G.; pontarotti, P.
10.1101/2021.05.04.442552 — evolutionary biology — Posted on 2021-05-04
4010 Rcompadre and Rage - two R packages to facilitate the use of the COMPADRE and COMADRE databases and calculation of life history traits from matrix population models
Jones, O. R.; Barks, P.; Stott, I. M.; James, T. D.; Levin, S. C.; Petry, W. K.; Capdevila, P.; Che-Castaldo, J.; Jackson, J.; Römer, G.; Schuette, C.; Thomas, C. C.; Salguero-Gomez, R.
10.1101/2021.04.26.441330 — ecology — Posted on 2021-05-04
4011 Modular development enables rapid design of media for alternative hosts
Biedermann, A. M.; Gengaro, I. R.; Rodriguez-Aponte, S. A.; Love, K. R.; Love, J. C.
10.1101/2021.04.30.442183 — microbiology — Posted on 2021-05-04
4014 Heme oxygenase limits mycobacterial infection-induced ferroptosis
Luo, K.; Stocker, R.; Britton, W. J. J.; Kikuchi, K.; Oehlers, S. H.
10.1101/2021.05.04.442683 — immunology — Posted on 2021-05-04
4016 Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile
Arrieta-Ortiz, M. L.; Immanuel, S. R. C.; Turkarslan, S.; Wu, W.-J.; Girinathan, B. P.; Worley, J. N.; DiBenedetto, N.; Soutourina, O.; Peltier, J.; Dupuy, B.; Bry, L.; Baliga, N. S.
10.1101/2020.09.14.297382 — systems biology — Posted on 2021-05-04
4018 The Immune landscape of solid pediatric tumors.
Sherif, S.; Roelands, J.; Mifsud, W.; Ahmed, E.; Mifsud, B.; Bedognetti, D.; Hendrickx, W.
10.1101/2021.05.04.442503 — cancer biology — Posted on 2021-05-04
4019 GEM-DeCan: Improved tumor immune microenvironment profiling through novel gene expression and DNA methylation signatures predicts immunotherapy response
XIE, T.; Pernet, J.; Verstraete, N.; Madrid-Mencia, M.; Kuo, M.-S.; Hucteau, A.; Coullomb, A.; Solorzano, J.; Oliver, D.; Cruzalegui, F.; Pancaldi, V.
10.1101/2021.04.09.439207 — bioinformatics — Posted on 2021-05-04
4021 NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the Brain
Liu, S.; Aldinger, K. A.; Cheng, C. V.; Kiyama, T.; Dave, M.; McNamara, H. K.; Caraffi, S. G.; Ivanovski, I.; Errichiello, E.; Zweier, C.; Zuffardi, O.; Schneider, M.; Papavasiliou, A. S.; Perry, M. S.; Cho, M. T.; Weber, A.; Swale, A.; Badea, T. C.; Mao, C.-A.; Garavelli, L.; Dobyns, W. B.; Reinberg, D.
10.1101/2021.03.30.437620 — biochemistry — Posted on 2021-05-04
4023 The central nucleus of the amygdala and gustatory cortex assess affective valence during CTA learning and expression in male and female rats
Bernanke, A.; Burnette, E.; Murphy, J.; Hernandez, N.; Zimmerman, S.; Walker, Q. D.; Wander, R.; Sette, S.; Reavis, Z.; Armstrong, C.; Risher, M.-L.; Kuhn, C.
10.1101/2021.05.04.442519 — animal behavior and cognition — Posted on 2021-05-04
4028 Endosomal cAMP production broadly impacts the cellular phosphoproteome
Tsvetanova, N. G.; Trester-Zedlitz, M.; Newton, B. W.; Peng, G. E.; Johnson, J. R.; Jimenez-Morales, D.; Kurland, A. P.; Krogan, N. J.; von Zastrow, M.
10.1101/2021.01.06.425636 — cell biology — Posted on 2021-05-04
4029 The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.
Ahmadi, M.; MacLeod, G.; Rajakulendran, N.; Kosic, M.; Yang, A.; Molaei, F.; Lin, S.; Steinhart, Z.; Park, N. I.; Dirks, P. B.; Angers, S.
10.1101/2021.05.04.442579 — cell biology — Posted on 2021-05-04
4030 YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth.
Goodall, E. C. A.; Isom, G. L.; Rooke, J. L.; Icke, C.; Pullela, K.; Zhang, B.; Rae, J.; Tan, W. B.; Winkle, M.; Delhaye, A.; Heinz, E.; Collet, J.-F.; Cunningham, A. F.; Blaskovich, M. A.; Parton, R. G.; Cole, J. A.; Chng, S. S.; Vollmer, W.; Bryant, J. A.; Henderson, I. R.
10.1101/2021.04.16.440158 — microbiology — Posted on 2021-05-04
4031 Generation of lineage-resolved complete metagenome-assembled genomes by precision phasing
Bickhart, D. M.; Kolmogorov, M.; Tseng, E.; Portik, D.; Korobeynikov, A.; Tolstoganov, I.; Uritskiy, G.; Liachko, I.; Sullivan, S. T.; Shin, S. B.; Zorea, A.; Andreu, V. P.; Panke-Buisse, K.; Medema, M. H.; Mizrahi, I.; Pevzner, P. A.; Smith, T. P.
10.1101/2021.05.04.442591 — microbiology — Posted on 2021-05-04
4032 Striatal BOLD and midfrontal theta power express motivation for action
Algermissen, J.; Swart, J. C.; Scheeringa, R.; Cools, R.; den Ouden, H. E. M.
10.1101/2020.09.11.292870 — neuroscience — Posted on 2021-05-04
4035 Cryptic costs of viral infection in a model social insect
Chapman, A.; Amiri, E.; Han, B.; McDermott, E.; Rueppell, O.; Tarpy, D. R.; Foster, L.; McAfee, A.
10.1101/2021.05.04.442681 — systems biology — Posted on 2021-05-04
4036 Biphasic Control of Cell Expansion by Auxin Coordinates Etiolated Seedling Development
Du, M.; Bou Daher, F.; Liu, Y.; Steward, A.; Tillman, M.; Zhang, X.; Wong, J. H.; Ren, H.; Cohen, J. D.; Li, C.; Gray, W. M.
10.1101/2021.05.04.442657 — plant biology — Posted on 2021-05-04
4037 Cold exposure drives weight gain and adiposity following chronic suppression of brown adipose tissue
Aldiss, P.; Lewis, J. E.; Lupini, I.; Bloor, I.; Chavoshinejad, R.; Boocock, D.; Miles, A. K.; Ebling, F. J. P.; Budge, H.; Symonds, M. E.
10.1101/789289 — physiology — Posted on 2021-05-04
4038 Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell cultures
Verheul, C.; Ntafoulis, I.; Kers, T.; Hoogstrate, Y.; Mastroberardino, P.; Barnhoorn, S.; Payan, C.; Tching Chi Yen, R.; Struys, E.; Koolen, S.; Dirven, C.; Leenstra, S.; French, P.; Lamfers, M.
10.1101/2021.04.09.435131 — cancer biology — Posted on 2021-05-04
4039 Cell-type specific requirement for pyruvate dehydrogenase in hematopoiesis and leukemia development.
Jun, S.; Mahesula, S.; Mathews, T. P.; Martin-Sandoval, M. S.; Zhao, Z.; Piskounova, E.; Agathocleous, M.
10.1101/2021.05.04.442528 — cancer biology — Posted on 2021-05-04
4041 SeqScreen: Accurate and Sensitive Functional Screening of Pathogenic Sequences via Ensemble Learning
Balaji, A.; Kille, B.; Kappell, A. D.; Godbold, G. D.; Diep, M.; Elworth, L. R. A.; Qian, Z.; Albin, D.; Nasko, D. J.; Shah, N.; Pop, M.; Segarra, S.; Ternus, K. L.; Treangen, T. J.
10.1101/2021.05.02.442344 — bioinformatics — Posted on 2021-05-04
4044 A universal pocket in FAALs ensures redirection of fatty acid pool away from CoA-based activation
Patil, G. S.; Kinatukara, P.; Mondal, S.; Shambhavi, S.; Patel, K. D.; Pramanik, S.; Dubey, N.; Narasimhan, S.; Madduri, M. K.; Pal, B.; Gokhale, R. S.; Sankaranarayanan, R.
10.1101/2021.05.04.442589 — biochemistry — Posted on 2021-05-04
4045 Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning
Koertel, N.; Rueckle, C.; Zhou, Y.; Busch, A.; Hoch-Kraft, P.; Sutandy, R. F.; Haase, J.; Pradhan, M.; Musheev, M.; Ostareck, D.; Ostareck-Lederer, A.; Dieterich, C.; Huettelmaier, S.; Niehrs, C.; Rausch, O.; Dominissini, D.; Koenig, J.; Zarnack, K.
10.1101/2020.12.20.423675 — genomics — Posted on 2021-05-04
4047 The sperm protein SPACA4 is required for efficient fertilization in mice
Herberg, S.; Fujihara, Y.; Blaha, A.; Panser, K.; Kobayashi, K.; Larasati, T.; Novatchkova, M.; Theussl, C. H.; Olszanska, O.; Ikawa, M.; Pauli, A.
10.1101/2021.05.02.442348 — developmental biology — Posted on 2021-05-04
4048 Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles
Sitarska, E.; Dias Almeida, S.; Beckwith, M.; Stopp, J.; Schwab, Y.; Sixt, M.; Kreshuk, A.; Erzberger, A.; Diz-Munoz, A.
10.1101/2021.03.26.437199 — cell biology — Posted on 2021-05-04
4052 Role of 5-HT2C receptors in zebrafish alarm reactions and post-exposure behavior
do Carmo Silva, R. X.; do Nascimento, B. G.; Gomes, G. C. V.; Holanda da Silva, N. A.; Pinheiro, J. S.; da Silva Chaves, S. N.; Pimentel, A. F. N.; Costa, B. P. D.; Herculano, A. M.; Lima-Maximino, M.; Maximino, C.
10.1101/2020.10.04.324202 — neuroscience — Posted on 2021-05-04
4053 Gradual development of non-adjacent dependency learning during early childhood
Paul, M.; Maennel, C.; van der Kant, A.; Mueller, J. L.; Hoehle, B.; Wartenburger, I.; Friederici, A. D.
10.1101/2020.09.01.277822 — neuroscience — Posted on 2021-05-04
4055 Continuous manipulation of mental representations is compromised in cerebellar degeneration
McDougle, S. D.; Tsay, J.; Pitt, B.; King, M.; Saban, W.; Taylor, J. A.; Ivry, R. B.
10.1101/2020.04.08.032409 — neuroscience — Posted on 2021-05-04
4060 INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions
Woolley, J. F.; Chen, K.; Genc, G. E.; Lee, D. K. C.; Dzneladze, I.; He, R.; Gabra, M. M.; Saffi, G. T.; Son, M. H.; Schoof, E. M.; Xie, S. Z.; Mangialardi, E. M.; Kotlyar, M.; Rashid, A.; Gams, M. S.; Vacher, J.; Guidos, C. J.; Jurisica, I.; Dick, J. E.; Botelho, R. J.; Minden, M. D.; Salmena, L.
10.1101/2021.03.25.437029 — cancer biology — Posted on 2021-05-04
4062 A massively multi-scale approach to characterising tissue architecture by synchrotron micro-CT applied to the human placenta
Tun, W. M.; Poologasundarampillai, G.; Bischof, H.; Nye, G.; King, O. N. F.; Basham, M.; Tokudome, Y.; Lewis, R. M.; Johnstone, E. D.; Brownbill, P.; Darrow, M.; Chernyavsky, I. L.
10.1101/2020.12.07.411462 — bioengineering — Posted on 2021-05-04
4063 Multiplexed single-cell proteomics using SCoPE2
Petelski, A. A.; Emmott, E.; Leduc, A.; Huffman, R. G.; Specht, H.; Perlman, D. H.; Slavov, N.
10.1101/2021.03.12.435034 — bioengineering — Posted on 2021-05-04
4064 Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments
Monti, M.; Guiducci, G.; Paone, A.; Rinaldo, S.; Liberati, F. R.; Giardina, G.; Cutruzzola, F.; Tartaglia, G.
10.1101/2020.12.24.424304 — biochemistry — Posted on 2021-05-04
4065 Glioblastoma mutations impair ligand discrimination by EGFR
Hu, C.; Leche, C. A.; Kiyatkin, A.; Stayrook, S. E.; Ferguson, K. M.; Lemmon, M. A.
10.1101/2021.05.04.442654 — biochemistry — Posted on 2021-05-04
4067 The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy
van der Grein, S. G.; Defourny, K. A. Y.; Rabouw, H. H.; Goerdayal, S. S.; van Herwijnen, M. J. C.; Wubbolts, R. W.; Altelaar, M.; van Kuppeveld, F. J. M.; Nolte-'t Hoen, E. N. M.
10.1101/2021.05.04.442556 — cell biology — Posted on 2021-05-04
4068 Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3
Martens, M. D.; Seshadri, N.; Nguyen, L.; Chapman, D.; Hensen, E. S.; Xiang, B.; Falk, L.; Mendoza, A.; Rattan, S.; Gibson, S. B.; Keijzer, R.; Saleem, A. D.; Hatch, G. M.; Doucette, C. A.; Karch, J. M.; Dolinsky, V. W.; Dixon, I. M.; West, A. R.; Rampitsch, C.; Gordon, J. W.
10.1101/2020.10.09.333666 — cell biology — Posted on 2021-05-04
4070 CFTR corrector efficacy is associated with occupancy of distinct binding sites
Baatallah, N.; Elbahnsi, A.; Mornon, J.-P.; Chevalier, B.; Pranke, I.; Servel, N.; Zelli, R.; Decout, J.-L.; Sermet-Gaudelus, I.; Edelman, A.; Callebaut, I.; Hinzpeter, A.
10.1101/2021.05.04.442442 — molecular biology — Posted on 2021-05-04
4071 Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity
Dimitriu, T.; Kurilovich, E.; Lapinska, U.; Severinov, K.; Pagliara, S.; Szczelkun, M. D.; Westra, E. R.
10.1101/2021.05.04.442568 — microbiology — Posted on 2021-05-04
4072 A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity Upon Viral Infection and Advanced Age
Joma, B. J.; Siwapornchai, N.; Vanguri, V. K.; Shrestha, A.; Roggensack, S. E.; Davidson, B. A.; Tai, A.; Hakansson, A. P.; Meydani, S. N.; Leong, J. M.; Bou Ghanem, E. N.
10.1101/2020.07.29.227991 — microbiology — Posted on 2021-05-04
4073 Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma
Vittoria, M. A.; Kingston, N. M.; Xia, E.; Hong, R.; Huang, L.; McDonald, S.; Tilston-Lunel, A.; Darp, R.; Campbell, J.; Lang, D.; Xu, X.; Ceol, C. J.; Varelas, X.; Ganem, N. J.
10.1101/2021.05.04.442615 — cancer biology — Posted on 2021-05-04
4074 ProtTrans: Towards Cracking the Language of Life's Code Through Self-Supervised Deep Learning and High Performance Computing
Elnaggar, A.; Heinzinger, M.; Dallago, C.; Rehawi, G.; Wang, Y.; Jones, L.; Gibbs, T.; Feher, T.; Angerer, C.; Steinegger, M.; BHOWMIK, D.; Rost, B.
10.1101/2020.07.12.199554 — bioinformatics — Posted on 2021-05-04
4076 Telomere-to-telomere genome assembly of Phaeodactylum tricornutum
Giguere, D. J.; Bahcheli, A. T.; Slattery, S. S.; Patel, R. R.; Flatley, M.; Karas, B. J.; Edgell, D. R.; Gloor, G. B.
10.1101/2021.05.04.442596 — genomics — Posted on 2021-05-04
4077 Same role but different actors: genetic regulation of post-translational modification of two distinct proteins
Landini, A.; Trbojevic-Akmacic, I.; Navarro, P.; Tsepilov, Y. A.; Sharapov, S. Z.; Vuckovic, F.; Polasek, O.; Hayward, C.; Petrovic, T.; Vilaj, M.; Aulchenko, Y. S.; Lauc, G.; Wilson, J. F.; Klaric, L.
10.1101/2021.05.04.442584 — genomics — Posted on 2021-05-04
4078 The role of elections as drivers of tropical deforestation
Morpurgo, J.; Kissling, W. D.; Tyrrell, P.; Negret, P. J.; Allan, J. R.
10.1101/2021.05.04.442551 — ecology — Posted on 2021-05-04
4080 Multi-view confocal microscopy enables multiple organ and whole organism live-imaging
Leroy, O.; Van Leen, E.; Girard, P.; Villedieu, A.; Hubert, C.; Bosveld, F.; Bellaïche, Y.; Renaud, O.
10.1101/2021.05.04.442565 — developmental biology — Posted on 2021-05-04
4083 TOPLESS promotes plant immunity by repressing auxin signaling and is targeted by the fungal effector Naked1
Navarrete, F.; Gallei, M.; Kornienko, A. E.; Saado, I.; Chia, K.-S.; Darino, M. A.; Khan, M.; Bindics, J.; Djamei, A.
10.1101/2021.05.04.442566 — plant biology — Posted on 2021-05-04
4087 Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge
Muruato, A.; Vu, M.; Johnson, B. A.; Davis-Gardner, M.; Vanderheiden, A. R.; Lokugamage, K.; Schindewolf, C.; Crocquet-Valdes, P. A.; Langsjoen, R. M.; Plante, J. A.; Plante, K. S.; Weaver, S. C.; Debbink, K.; Routh, A. L.; Walker, D. H.; Suthar, M. S.; Shi, P.-Y.; Xie, X.; Menachery, V. D.
10.1101/2021.05.03.442357 — microbiology — Posted on 2021-05-04
4089 CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection
Vanderheiden, A.; Thomas, J.; Soung, A. L.; Davis-Gardner, M. E.; Floyd, K.; Jin, F.; Cowan, D. A.; Pellegrini, K.; Creanga, A.; Pegu, A.; Derrien-Colemyn, A.; Shi, P.-Y.; Grakoui, A.; Klein, R. S.; Bosinger, S. E.; Kohlmeier, J. E.; Menachery, V. D.; Suthar, M. S.
10.1101/2021.05.03.442538 — immunology — Posted on 2021-05-04
4090 Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients
Ashokkumar, C.; Rohan, V.; Kroemer, A. H.; Rao, S.; Mazariegos, G.; Higgs, B. W.; Nadig, S.; Almeda, J.; Dhani, H.; Khan, K.; Yazigi, N.; Ekong, U.; Kaufman, S.; Betancourt-Garcia, M. M.; Mukund, K.; Sethi, P.; Mehrotra, S.; Soltys, K.; Singh, M. S.; Bond, G.; Khanna, A.; Ningappa, M.; Spishock, B.; Sindhi, E.; Atale, N.; Saunders, M.; Baliga, P.; Fishbein, T.; Subramaniam, S.; Sindhi, R.
10.1101/2021.05.03.442371 — immunology — Posted on 2021-05-04
4091 An interpretable connectivity-based decoding model for classification of chronic marijuana use
Kulkarni, K. R.; Schafer, M.; Berner, L.; Fiore, V. G.; Heflin, M.; Pandey, G.; Hutchison, K.; Calhoun, V.; Filbey, F.; Schiller, D.; Gu, X.
10.1101/2021.05.04.442433 — neuroscience — Posted on 2021-05-04
4095 The Hypoxia Response Pathway Promotes PEP Carboxykinase Expression And Gluconeogenesis
Vora, M.; Pyonteck, S. M.; Matlack, T. L.; Prashar, A.; Kane, N. S.; Shah, P.; Rongo, C.
10.1101/2021.05.04.442650 — genetics — Posted on 2021-05-04
4099 Increased mitochondrial activity upon CatSper channel activation is required for sperm capacitation.
Ferreira, J. J.; Cassina, A.; Irigoyen, P.; Ford, M.; Pietroroia, S.; Radi, R.; Santi, C. M.; Sapiro, R.
10.1101/2021.05.04.442630 — cell biology — Posted on 2021-05-04
4102 Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model
Tsai, C.-Y.; Chou, Y.-C.; Chen, C.-Y.; Jan, J.-T.; Chang, M.-L.; Lu, L.-A.; Huang, P.-Y.; Hsu, T.-T.; Hsueh, Y.-P.
10.1101/2021.05.04.441029 — microbiology — Posted on 2021-05-04
4104 Circadian Control of Heparan Sulfate Levels Times Phagocytosis of Amyloid Beta Aggregates
Clark, G. T.; Yu, Y.; Urban, C. A.; Fu, G.; Wang, C.; Zhang, F.; Linhardt, R. J.; Hurley, J. M.
10.1101/2021.05.04.442651 — immunology — Posted on 2021-05-04
4105 Contingent-behavior assay shows zebrafish preference for alcohol is biphasic
Nathan, F. M.; Kibat, C.; Goel, T.; Stewart, J.; Claridge-Chang, A.; Mathuru, A. S.
10.1101/2021.05.04.442404 — neuroscience — Posted on 2021-05-04
4106 Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects cognitive behavior
Fang, L.; Zhao, N.; Caudal, L.; Zhao, R.; Lin, C.-H.; Chang, H.-F.; Hainz, N.; Meier, C.; Bettler, B.; Huang, W.; Scheller, A.; Kirchhoff, F.; Bai, X.
10.1101/2021.05.04.442422 — neuroscience — Posted on 2021-05-04
4107 AZBA: A 3D Adult Zebrafish Brain Atlas for the Digital Age
Kenney, J. W.; Steadman, P. E.; Young, O.; Shi, M. T.; Polanco, M.; Dubaishi, S.; Mueller, T.; Frankland, P. W.
10.1101/2021.05.04.442625 — neuroscience — Posted on 2021-05-04
4108 Transcriptome analysis of heterogeneity in mouse model of metastatic breast cancer
Ionkina, A.; Balderrama-Gutierrez, G.; Ibanez, K.; Phan, S.; Cortez, A.; Mortazavi, A.; Prescher, J. A.
10.1101/2021.05.04.442511 — cancer biology — Posted on 2021-05-04
4111 Phasing Alleles Improves Network Inference with Allopolyploids
Tiley, G. P.; Crowl, A. A.; Manos, P. S.; Sessa, E. B.; Solis-Lemus, C.; Yoder, A. D.; Burleigh, J. G.
10.1101/2021.05.04.442457 — evolutionary biology — Posted on 2021-05-04
4113 Immunolocalization studies of vimentin and ACE2 on the surface of cells exposed to SARS-CoV-2 Spike proteins
Lalioti, V.; Gonzalez-Sanz, S.; Lois-Bermejo, I.; Gonzalez-Jimenez, P.; Viedma-Poyatos, A.; Merino, A.; Pajares, M. A.; Perez-Sala, D.
10.1101/2021.05.04.442648 — cell biology — Posted on 2021-05-04
4115 A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice
Shapira, T.; Monreal, I. A.; Dion, S. P.; Jager, M.; Desilets, A.; Olmstead, A. D.; Vandal, T.; Buchholz, D. W.; Imbiakha, B.; Gao, G.; Chin, A.; Rees, W. D.; Steiner, T.; Nabi, I. R.; Marsault, E.; Sahler, J.; August, A.; Van de Walle, G.; Whittaker, G. R.; Boudreault, P.-L.; Aguilar, H. C.; Leduc, R.; Jean, F.
10.1101/2021.05.03.442520 — microbiology — Posted on 2021-05-04
4117 Highly functional Cellular Immunity in SARS-CoV-2 Non-Seroconvertors is associated with immune protection
Kilpelainen, A.; Jimenez-Moyano, E.; Blanch-Lombarte, O.; Ouchi, D.; Penya, R.; Quirant-Sanchez, B.; Chamorro, A.; Blanco, I.; Martinez-Caceres, E.; Paredes, R.; Mateu, L.; Carrillo, J.; Blanco, J.; Brander, C.; Massanella, M.; Clotet, B.; G Prado, J.
10.1101/2021.05.04.438781 — immunology — Posted on 2021-05-04
4118 Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens
Mayadas, T.; Mysore, V.; Cullere, X.; Settles, M. L.; Kattan, M.; Ji, X.; Desjardins, M.; Durbin-Johnson, B.; Gilboa, T.; Baden, L.; Walt, D.; Andrew, L.; Jehi, L.
10.1101/2021.05.03.441323 — immunology — Posted on 2021-05-04
4124 Semi-supervised identification of SARS-CoV-2 molecular targets
Beck, K. L.; Seabolt, E.; Agarwal, A.; Nayar, G.; Bianco, S.; Krishnareddy, H.; Mukherjee, V.; Kaufman, J. H.
10.1101/2021.05.03.440524 — bioinformatics — Posted on 2021-05-04
4125 Mobile antimicrobial resistance genes in probiotics
Toth, A. G.; Csabai, I.; Judge, M. F.; Maroti, G.; Becsei, A.; Spisak, S.; Solymosi, N.
10.1101/2021.05.04.442546 — genomics — Posted on 2021-05-04
4127 Forest structure and degradation drive canopy gap sizes across the Brazilian Amazon
Reis, C. R.; Jackson, T. D.; Gorgens, E. B.; Dalagnol, R.; Jucker, T.; Nunes, M. H.; Ometto, J. P.; Aragao, L.; Rodriguez, L. C.; Coomes, D.
10.1101/2021.05.03.442416 — ecology — Posted on 2021-05-04
4130 The post-acute phase of SARS-CoV-2 infection in two macaques species is associated with signs of ongoing virus replication and pathology in pulmonary and extrapulmonary tissues
Boszormenyi, K. P.; Stammes, M. A.; Fagrouch, Z. C.; Kiemenyi-Kayere, G.; Niphuis, H.; Mortier, D.; van Driel, N.; Nieuwenhuis, I.; Vervenne, R.; Haaksma, T.; Ouwerling, B.; Adema, D.; Acar, R. F.; Zuiderwijk-Sick, E.; Meijer, L.; Mooij, P.; Remarque, E. J.; Oostermeijer, H.; Koopman, G.; Hoste, A. C. R.; Sastre, P.; Haagmans, B. L.; Bontrop, R. E.; Langermans, J. A. M.; Bogers, W. M.; Kondova, I.; Verschoor, E. J.; Verstrepen, B. E.
10.1101/2020.11.05.369413 — microbiology — Posted on 2021-05-04
4131 LY-CoV1404 potently neutralizes SARS-CoV-2 variants
Westendorf, K.; Zentelis, S.; Foster, D.; Vaillancourt, P.; Wiggin, M.; Lovett, E.; Hendle, J.; Pustilnik, A.; Sauder, J. M.; Kraft, L.; Hwang, Y.; Siegel, R. W.; Chen, J.; Heinz, B. A.; Higgs, R. E.; Kalleward, N.; Jepson, K.; Goya, R.; Smith, M. A.; Collins, D. W.; Pellacani, D.; Xiang, P.; de Puyraimond, V.; Ricicova, M.; Devorkin, L.; Pritchard, C.; O'Neill, A.; Cohen, C.; Dye, J.; Huie, K. I.; Badger, C. V.; Kobasa, D.; Audet, J.; Freitas, J. J.; Hassanali, S.; Hughes, I.; Munoz, L.; Palma, H. C.; Ramamurthy, B.; Cross, R. W.; Geisbert, T. W.; Borisevich, V.; Lanz, I.; Anderson, L.; Sipah
10.1101/2021.04.30.442182 — immunology — Posted on 2021-05-04
4135 A high-continuity and annotated tomato reference genome
Su, X.; Wang, B.; Geng, X.; Du, Y.; Yang, Q.; Liang, B.; Meng, G.; Gao, Q.; Huang, S.; Yang, W.; Zhu, Y.; Lin, T.
10.1101/2021.05.04.441887 — genomics — Posted on 2021-05-04
4136 Unbiased and UMI-informed sequencing of cell-free miRNAs at single-nucleotide resolution
van Eijndhoven, M. A. J.; Aparicio-Puerta, E.; Gomez-Martin, C.; Medina, J. M.; Drees, E. E. E.; Bradley, E. J.; Bosch, L.; Scheepbouwer, C.; Hackenberg, M.; Pegtel, D. M.
10.1101/2021.05.04.442244 — genomics — Posted on 2021-05-04
4137 Imaging Nanoscale Nuclear Structures with Expansion Microscopy
Faulkner, E. L.; Pike, J. A.; Densham, R. M.; Garlick, E. R.; Thomas, S. G.; Neely, R. K.; Morris, J. R.
10.1101/2021.05.04.442164 — molecular biology — Posted on 2021-05-04
4139 Splice-specific lyn knockout mice reveal a dominant function of LynB in preventing autoimmunity
Brian, B. F.; Sauer, M. L.; Ruis, B. L.; Auger, J. L.; Senevirathne, S. E.; Swanson, W. L.; Nunez, M. G.; Moriarity, B. S.; Lowell, C. A.; Binstadt, B. A.; Freedman, T. S.
10.1101/2021.05.03.439514 — immunology — Posted on 2021-05-04
4142 Asynchronous glutamate exocytosis is enhanced in low release probability synapses and is widely dispersed across the active zone
Mendonca, P.; Tagliatti, E.; Langley, H.; Kotzadimitriou, D.; Zamora-Chimal, C.; Timofeeva, Y.; Volynski, K.
10.1101/2021.05.04.441792 — neuroscience — Posted on 2021-05-04
4144 Accurate de novo identification of biosynthetic gene clusters with GECCO
Carroll, L. M.; Larralde, M.; Fleck, J. S.; Ponnudurai, R.; Milanese, A.; Cappio Barazzone, E.; Zeller, G.
10.1101/2021.05.03.442509 — bioinformatics — Posted on 2021-05-04
4146 Benchmark of data processing methods and machine learning models for gut microbiome-based diagnosis of inflammatory bowel disease
Kubinski, R.; Djamen-Kepaou, J.-Y.; Zhanabaev, T.; Hernandez-Garcia, A.; Bauer, S.; Hildebrand, F.; Korcsmaros, T.; Karam, S.; Jantchou, P.; Kafi, K.; Martin, R. D.
10.1101/2021.05.03.442488 — microbiology — Posted on 2021-05-04
4147 Epigenetic Programming during thymic development sets the stage for optimal function in effector T cells via DNA demethylation
Teghanemt, A.; Pulipati, P.; Day, K.; Yorek, M. S.; Yi, R.; Misel, K. M.; Keen, H. L.; Au, C.; Maretzky, T.; Gurung, P.; Littman, D. R.; Issuree, P. D.
10.1101/2021.05.03.442517 — immunology — Posted on 2021-05-04
4148 Minian: An open-source miniscope analysis pipeline
Dong, Z.; Mau, W.; Feng, Y.; Pennington, Z. T.; Chen, L.; Zaki, Y.; Rajan, K.; Shuman, T.; Aharoni, D.; Cai, D. J.
10.1101/2021.05.03.442492 — neuroscience — Posted on 2021-05-04
4150 Single-cell gene regulatory network inference atscale: The Inferelator 3.0
Skok Gibbs, C.; Jackson, C. A.; Saldi, G.-A.; Shah, A.; Tjärnberg, A.; Watters, A.; De Veaux, N.; Tchourine, K.; Yi, R.; Hamamsy, T.; Castro, D. M.; Carriero, N.; Gresham, D.; Miraldi, E. R.; Bonneau, R.
10.1101/2021.05.03.442499 — systems biology — Posted on 2021-05-04
4152 The maize E3 ligase ZmCER9 specifically targets activated NLRs for degradation
Karre, S.; Kim, S.-B.; Selote, D.; Khangura, R.; Dilkes, B.; Johal, G. S.; Balint-Kurti, P.
10.1101/2021.05.03.442530 — plant biology — Posted on 2021-05-04
4154 Aberrant BCMA Signaling Promotes Tumor Growth by Altering Protein Translation Machinery, a Therapeutic Target for the Treatment of Relapse/Refractory Multiple Myeloma
Miao, Y. R.; Cenik, C.; Jiang, D.; Mizuno, K.; Li, G. C.; Zhao, H.; Thakker, K.; Diep, A.; Xu, J. Y.; Zhang, X. E.; Liedtke, M.; Abidi, P.; Leung, W.-s.; Koong, A. C.; Giaccia, A. J.
10.1101/2021.05.03.442500 — cancer biology — Posted on 2021-05-04
4155 MLL4 is a critical mediator of differentiation and ferroptosis in the epidermis
Egolf, S.; Zou, J.; Anderson, A.; Aubert, Y.; Ge, K.; Seykora, J. T.; Capell, B. C.
10.1101/2021.05.03.442432 — cancer biology — Posted on 2021-05-04
4156 Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment
Varn, F. S.; Johnson, K. C.; Wade, T. E.; Malta, T. M.; Sabedot, T. S.; Barthel, F. P.; Kim, H.; Ahmed, N.; Datta, I.; Barnholtz-Sloan, J. S.; Bakas, S.; D'Angelo, F.; Gan, H. K.; Garofano, L.; Huse, J. T.; Khasraw, M.; Kocakavuk, E.; Migliozzi, S.; Ormond, D. R.; Paek, S. H.; Van Meir, E. G.; Walenkamp, A. M. E.; Watts, C.; Weller, M.; Weiss, T.; Wesseling, P.; Stead, L. F.; Poisson, L. M.; Noushmehr, H.; Iavarone, A.; Verhaak, R. G.; The GLASS Consortium,
10.1101/2021.05.03.442486 — cancer biology — Posted on 2021-05-04
4158 Structural visualization of de novo initiation of RNA polymerase II transcription
Yang, C.; Fujiwara, R.; Kim, H. J.; Gorbea Colón, J. J.; Steimle, S.; Garcia, B. A.; Murakami, K.
10.1101/2021.05.03.442346 — biophysics — Posted on 2021-05-04
4161 Automation assisted anaerobic phenotyping for metabolic engineering
Raj, K.; Venayak, N.; Diep, P.; Golla, S. A.; Yakunin, A. F.; Mahadevan, R.
10.1101/2021.05.03.442526 — bioengineering — Posted on 2021-05-04
4162 Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin
Chan, M.; Yuan, H.; Soifer, I.; Maile, T. M.; Wang, R. Y.; Ireland, A.; O'Brien, J.; Goudeau, J.; Chan, L.; Vijay, T.; Freund, A.; Kenyon, C.; Bennett, B.; McAllister, F.; Kelley, D. R.; Roy, M.; Cohen, R. L.; Levinson, A. D.; Botstein, D.; Hendrickson, D.
10.1101/2021.05.03.442497 — genomics — Posted on 2021-05-04
4163 Ablation of mpeg+ macrophages exacerbates mfrp-related hyperopia
Brandt, Z. J.; Collery, R. F.; Besharse, J. C.; Link, B. A.
10.1101/2021.05.03.442504 — genetics — Posted on 2021-05-04
4166 Multi-tissue methylation clocks for age estimation in the common bottlenose dolphin
Robeck, T. R.; Fei, Z.; Haghani, A.; Zoller, J. A.; Li, C. Z.; Steinman, K.; DiRocco, S.; Staggs, L.; Schmitt, T.; Osborn, S.; Montano, G.; Rodriguez, M.; Horvath, S.
10.1101/2021.05.03.442523 — developmental biology — Posted on 2021-05-04
4167 Generation of SIV resistant T cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 locus
D'Souza, S. S.; Kumar, A.; Weinfurter, J.; Park, M. A.; Maufort, J.; Tao, L.; Kang, H.; Golos, T.; Thomson, J. A.; Reynolds, M.; Slukvin, I. I.
10.1101/2021.05.03.442446 — cell biology — Posted on 2021-05-04
4169 Stereotypic expansion of Tregulatory and Th17 cells during infancy is disrupted by HIV exposure and gut epithelial damage.
Dzanibe, S.; Lennard, K.; Kiravu, A.; Seabrook, M. S. S.; Alinde, B.; Holmes, S. P.; Blish, C. A.; Jaspan, H. B.; Gray, C. M.
10.1101/2021.05.03.442468 — immunology — Posted on 2021-05-04
4171 Binocular Mirror-Symmetric Microsaccadic Sampling of Hyperacute 3D-Vision
Kemppainen, J.; Scales, B.; Razban Haghighi, K.; Takalo, J.; Mansour, N.; McManus, J.; Lego, G.; Saari, P.; Hurcomb, J.; Antohi, A.; Suuronen, J.-P.; Blanchard, F.; Hardie, R. C.; song, z.; Hampton, M.; Eckermann, M.; Westermeier, F.; Frohn, J.; Hoekstra, H.; Lee, C.-H.; Huttula, M.; Mokso, R.; Juusola, M.
10.1101/2021.05.03.442473 — neuroscience — Posted on 2021-05-04
4172 A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance
Yang, K.; Longo, L.; Narita, Z.; Cascella, N.; Nucifora, F. C.; Coughlin, J. M.; Nestadt, G.; Sedlak, T. W.; Mihaljevic, M.; Wang, M.; Kenkare, A.; Nagpal, A.; Sethi, M.; Kelly, A.; Di Carlo, P.; Kamath, V.; Faria, A.; Barker, P. B.; Sawa, A.
10.1101/2021.05.03.442450 — neuroscience — Posted on 2021-05-04
4173 Digital 3D Brain MRI Arterial Territories Atlas
Liu, C.-F.; Hsu, J.; Xu, X.; Kim, N. G.; Sheppard, S.; Meier, E.; Miller, M.; Hillis, A. E.; Faria, A. V.
10.1101/2021.05.03.442478 — neuroscience — Posted on 2021-05-04
4176 A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor
Inoue, A.; Janke, L. J.; Gudenas, B. L.; Jin, H.; Fan, Y.; Pare, J.; Clay, M. R.; Northcott, P. A.; Hirbe, A. C.; Cao, X.
10.1101/2021.05.03.442481 — cancer biology — Posted on 2021-05-04
4181 A proteomics database for CNS proteins of the great pond snail Lymnaea stagnalis
Wooller, S.; Anagnostopoulou, A.; Kuropka, B.; Crossley, M.; Benjamin, P. R.; Pearl, F.; Kemenes, I.; Kemenes, G.; Eravci, M.
10.1101/2021.05.03.442491 — bioinformatics — Posted on 2021-05-04
4185 Gain control by sparse, ultra-slow glycinergic synapses
Jain, V.; Hanson, L.; Sethuramanujam, S.; Gregg, R. G.; Zhang, C.; Smith, R. G.; Berson, D.; McCall, M.; Awatramani, G. B.
10.1101/2021.05.03.442480 — neuroscience — Posted on 2021-05-04
4186 Ultrasound stimulation of the motor cortex during tonic muscle contraction
Heimbuch, I. S.; Fan, T.; Wu, A.; Faas, G. C.; Charles, A. C.; Iacoboni, M.
10.1101/2021.05.03.442483 — neuroscience — Posted on 2021-05-04
4187 Raabin-WBC: a large free access dataset of white blood cells from normal peripheral blood
Mousavi Kouzehkanan, S.-Z.; Saghari, S.; Tavakoli, E.; Rostami, P.; AbbasZadeh, M.; Shahabi Satlsar, E.; Mirzadeh, F.; Gheidishahran, M.; Gorgi, F.; Mohammadi, S.; Hosseini, R.
10.1101/2021.05.02.442287 — bioengineering — Posted on 2021-05-04
4188 The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties
Tarczewska, A.; Kolonko-Adamska, M.; Zarebski, M.; Dobrucki, J. W.; Ozyhar, A.; Greb-Markiewicz, B.
10.1101/2021.05.03.442392 — biochemistry — Posted on 2021-05-04
4190 Possible role of accessory proteins in the viral replication for the 20I/501Y.V1 (B.1.1.7) SARS-CoV-2 variant
Nyayanit, D. A.; Sarkale, P.; Shete-Aich, A.; Kumar, A.; Patil, S.; Majumdar, T.; Baradkar, S.; Gawande, P.; Mohandas, S.; Yadav, P. D.
10.1101/2021.04.30.442222 — microbiology — Posted on 2021-05-04
4191 The Immunological Factors Predisposing To Severe COVID-19 Are Already Present In Healthy Elderly And Men
Kilic, G.; Bulut, O.; Jaeger, M.; ter Horst, R.; Koeken, V.; Moorlag, S. J. C. F. M.; Mourits, V.; de Bree, C.; Dominguez-Andres, J.; Joosten, L. A. B.; Netea, M.
10.1101/2021.04.30.442229 — immunology — Posted on 2021-05-04
4193 Trophic niche of the invasive gregarious species Crepidula fornicata, in relation to ontogenic changes
Androuin, T.; Dubois, S. F.; Hubas, C.; Lefebvre, G.; Le Grand, F.; Schaal, G.; Carlier, A.
10.1101/2020.07.30.229021 — ecology — Posted on 2021-05-04
4194 A physicochemical model of odor sampling
Gronowitz, M. E.; Liu, A.; Qiu, Q.; Yu, C. R.; Cleland, T. A.
10.1101/2020.06.16.154807 — neuroscience — Posted on 2021-05-04
4195 Muscle fatigue revisited - Insights from optically pumped magnetometers
Sometti, D.; Semeia, L.; Chen, H.; Dax, J.; Kronlage, C.; Baek, S.; Kirchgaessner, M.; Romano, A.; Heilos, J.; Staber, D.; Oppold, J.; Righetti, G.; Middelmann, T.; Braun, C.; Broser, P.; Marquetand, J.
10.1101/2021.05.03.442396 — physiology — Posted on 2021-05-04
4196 Relative time constraints improve molecular dating
Szollosi, G. J.; Hoehna, S.; Williams, T. A.; Schrempf, D.; Daubin, V.; Boussau, B.
10.1101/2020.10.17.343889 — evolutionary biology — Posted on 2021-05-04
4197 Lyl-1 regulates primitive macrophages and microglia development
Wang, S.; Ren, D.; Kaushik, A.-L.; Matherat, G.; Lecluse, Y.; Filipp, D.; Vainchenker, W.; Raslova, H.; Plo, I.; Godin, I.
10.1101/2020.09.28.316570 — developmental biology — Posted on 2021-05-04
4198 Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
Wang, R. K.; Ascanelli, C.; Abdelbaki, A. M.; Fung, A. Y.; Rasmusson, T.; Michaelides, I.; Roberts, K.; Lindon, C.
10.1101/2020.07.22.215814 — cell biology — Posted on 2021-05-04
4201 Recurrent Emergence of an Antiviral Defense through Repeated Retrotransposition and Truncation of CHMP3
Rheinemann, L.; Downhour, D. M.; Davenport, K. A.; McKeown, A. N.; Necessary, C. R.; Sundquist, W. I.; Elde, N. C.
10.1101/2021.04.27.441704 — evolutionary biology — Posted on 2021-05-03
4203 A synthetic protein as efficient multitarget regulator against complement over-activation
Ruiz Molina, N.; Parsons, J.; Mueller, M.; Hoernstein, S. N. W.; Bohlender, L. L.; Pumple, S.; Zipfel, P. F.; Haeffner, K.; Reski, R.; Decker, E. L.
10.1101/2021.04.27.441647 — immunology — Posted on 2021-05-03
4204 Basal forebrain cholinergic neurons are part of the threat memory engram
Rajebhosale, P.; Ananth, M. R.; Crouse, R. B.; Jiang, L.; Lopez- Hernandez, G.; Arty, C.; Wang, S.; Jone, A.; Zhong, C.; Desai, N.; Li, Y.; Picciotto, M.; Role, L. W.; Talmage, D. A.
10.1101/2021.05.02.442364 — neuroscience — Posted on 2021-05-03
4207 Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization
Henning, N. J.; Boike, L.; Spradlin, J. N.; Ward, C. C.; Belcher, B.; Brittain, S. M.; Hesse, M.; Dovala, D.; McGregor, L. M.; McKenna, J. M.; Tallarico, J. A.; Schirle, M.; Nomura, D. K.
10.1101/2021.04.30.441959 — biochemistry — Posted on 2021-05-03
4208 A Genome-Phenome Association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA
Yang, W.; Lin, Y.-C.; Johnson, W.; Dai, N.; Vaisvila, R.; Weigele, P. R.; Lee, Y.-J.; Correa, I. R.; Schildkraut, I.; Ettwiller, L.
10.1101/2021.03.23.436658 — genomics — Posted on 2021-05-03
4212 Sperm membrane proteins DCST1 and DCST2 are required for the sperm-egg fusion process in mice and fish
Noda, T.; Blaha, A.; Fujihara, Y.; Gert, K. R.; Emori, C.; Deneke, V. E.; Oura, S.; Berent, S.; Kodani, M.; Panser, K.; Cabrera-Quio, L. E.; Pauli, A.; Ikawa, M.
10.1101/2021.04.18.440256 — developmental biology — Posted on 2021-05-03
4213 The landscape of high-affinity human antibodies against intratumoral antigens
Rakocevic, G.; Gotlova, I.; de Santiago, I.; Toptas, B. C.; Popovic, M.; Popovic, M.; Leone, D. A.; Stachyra, A. L.; Rozenfeld, R.; Kural, D.; Biasci, D.
10.1101/2021.02.06.430058 — immunology — Posted on 2021-05-03
4214 Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation
McComb, S.; Nguyen, T.; Henry, K. A.; Bloemberg, D.; Bloemberg, D.; Marcil, A.; Maclean, S.; Gilbert, R.; Gadoury, C.; Pon, R.; Sulea, T.; Zhu, Q.; Weeratna, R. D.
10.1101/2020.10.30.360925 — immunology — Posted on 2021-05-03
4215 Enhancing and inhibitory motifs have coevolved to regulate CD4 activity
Lee, M. S.; Tuohy, P. J.; Kim, C.; Lichauco, K.; Parrish, H. L.; Van Doorslaer, K.; Kuhns, M. S.
10.1101/2021.04.29.441928 — immunology — Posted on 2021-05-03
4220 INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions
Woolley, J. F.; Chen, K.; Genc, G. E.; Lee, D. K. C.; Dzneladze, I.; He, R.; Gabra, M. M.; Saffi, G. T.; Son, M. H.; Schoof, E. M.; Xie, S. Z.; Kotlyar, M.; Rashid, A.; Gams, M. S.; Vacher, J.; Guidos, C. J.; Jurisica, I.; Dick, J. E.; Botelho, R. J.; Minden, M. D.; Salmena, L.
10.1101/2021.03.25.437029 — cancer biology — Posted on 2021-05-03
4223 Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
Tsai, K.; Stojkovic, V.; Noda-Garcia, L.; Young, I. D.; Myasnikov, A. G.; Kleinman, J.; Palla, A.; Floor, S. N.; Frost, A.; Fraser, J. S.; Tawfik, D. S.; Galonic Fujimori, D.
10.1101/2021.03.12.435202 — biochemistry — Posted on 2021-05-03
4227 Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3
Martens, M. D.; Seshadri, N.; Nguyen, L.; Chapman, D.; Hensen, E. S.; Xiang, B.; Falk, L.; Mendoza, A.; Rattan, S.; Gibson, S. B.; Keijzer, R.; Saleem, A. D.; Hatch, G. M.; Doucette, C. A.; Karch, J. M.; Dolinsky, V. W.; Dixon, I. M.; West, A. R.; Rampitsch, C.; Gordon, J. W.
10.1101/2020.10.09.333666 — cell biology — Posted on 2021-05-03
4228 Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome
Lam, K. N.; Spanogiannopoulos, P.; Soto-Perez, P.; Alexander, M.; Nalley, M. J.; Bisanz, J. E.; Nayak, R. R.; Weakley, A. M.; Yu, F. B.; Turnbaugh, P. J.
10.1101/2020.07.09.193847 — microbiology — Posted on 2021-05-03
4229 Rhinovirus reduces the severity of subsequent respiratory viral infections by interferon-dependent and -independent mechanisms
Van Leuven, J. T.; Gonzalez, A. J.; Ijezie, E. C.; Wixom, A. Q.; Clary, J. L.; Naranjo, M. N.; Ridenhour, B. J.; Miller, C. R.; Miura, T. A.
10.1101/2020.11.06.371005 — microbiology — Posted on 2021-05-03
4231 Context Free and Context-Dependent Conceptual Representation in the Temporal Lobes
Gao, Z.; Zheng, L.; Gouws, A.; Krieger-Redwood, K.; Wang, X.; Varga, D.; Smallwood, J.; Jefferies, E.
10.1101/2021.05.03.442424 — neuroscience — Posted on 2021-05-03
4233 Neuroplasticity associated with changes in conversational turn-taking following a family-based intervention
Romeo, R. R.; Leonard, J. A.; Grotzinger, H. M.; Robinson, S. T.; Takada, M. E.; Mackey, A. P.; Scherer, E.; Rowe, M. L.; West, M. R.; Gabrieli, J. D. E.
10.1101/2020.10.30.362723 — neuroscience — Posted on 2021-05-03
4235 Vitamin C inhibits SARS coronavirus-2 main protease essential for viral replication
Malla, T. N.; Pandey, S.; Poudyal, I.; Aldama, L.; Feliz, D.; Noda, M.; Phillips, G. N.; Stojkovic, E. A.; Schmidt, M.
10.1101/2021.05.02.442358 — biophysics — Posted on 2021-05-03
4241 ACE2 expression in rat brain: implications for COVID-19 associated neurological manifestations
Hernandez, V. S.; Zetter, M. A.; Guerra, E. C.; Hernandez-Araiza, I.; Karuzin, N.; Hernandez-Perez, O. R.; Eiden, L. E.; Zhang, L.
10.1101/2021.05.01.442293 — neuroscience — Posted on 2021-05-03
4245 The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)
Ebrahim, A.; Riley, B. T.; Kumaran, D.; Andi, B.; Fuchs, M. R.; McSweeney, S.; Keedy, D. A.
10.1101/2021.05.03.437411 — biophysics — Posted on 2021-05-03
4246 SARS-CoV-2 Genome Sequencing Methods Differ In Their Ability To Detect Variants From Low Viral Load Samples
Lam, C.; Gray, K.-A.; Gall, M.; Sadsad, R.; Arnott, A.; Johnson-Mackinnon, J.; Fong, W.; Basile, K.; Kok, J.; Dwyer, D. E.; Sintchenko, V.; Rockett, R. J.
10.1101/2021.05.01.442304 — microbiology — Posted on 2021-05-03
4247 Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7
Lamers, M. M.; Breugem, T. I.; Mykytyn, A. Z.; Wang, Y.; Groen, N.; Knoops, K.; Schipper, D.; van der Vaart, J.; Koopman, C. D.; Zhang, J.; Wu, D. C.; van den Doel, P. B.; Bestebroer, T.; GeurtsvanKessel, C. C.; Peters, P. J.; Muraro, M. J.; Clevers, H.; Wu, N. C.; Haagmans, B. L.
10.1101/2021.05.03.441080 — microbiology — Posted on 2021-05-03
4248 Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
Apostolidis, S. A.; Sarkar, A.; Giannini, H. M.; Goel, R. R.; Mathew, D.; Suzuki, A.; Baxter, A. E.; Greenplate, A. R.; Alanio, C.; Abdel-Hakeem, M.; Oldridge, D. A.; Giles, J. R.; Wu, J. E.; Chen, Z.; Huang, Y. J.; Pattekar, A.; Manne, S.; Kuthuru, O.; Dougherty, J.; Weiderhold, B.; Weisman, A. R.; Ittner, C. A. G.; Gouma, S.; Dunbar, D.; Frank, I.; Huang, A. C.; Vella, L. A.; The UPenn COVID Processing Unit, ; Reilly, J. P.; Hensley, S. E.; Rauova, L.; Zhao, L.; Meyer, N. J.; Poncz, M.; Abrams, C. S.; Wherry, E. J.
10.1101/2021.05.01.442279 — immunology — Posted on 2021-05-03
4249 Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals
Chen, E. C.; Gilchuk, P.; Zost, S. J.; Suryadevara, N.; Winkler, E. S.; Cabel, C. R.; Binshtein, E.; Sutton, R. E.; Rodriguez, J. L.; Day, S.; Myers, L.; Trivette, A.; Williams, J. K.; Davidson, E.; Li, S.; Doranz, B. J.; Campos, S. K.; Carnahan, R. H.; Thorne, C. A.; Diamond, M. S.; Crowe, J. E.
10.1101/2021.05.02.442326 — immunology — Posted on 2021-05-03
4250 Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice
Carter, B.; Chen, J.; Kaseke, C.; Dimitrakakis, A.; Gaiha, G. D.; Xu, Q.; Gifford, D. K.
10.1101/2021.05.02.442052 — immunology — Posted on 2021-05-03
4251 SARS -CoV-2 T-cell immunity to variants of concern following vaccination
Gallagher, K. M. E.; Leick, M. B.; Larson, R. C.; Berger, T. R.; Katsis, K.; Yam, J. Y.; Brini, G.; Grauwet, K.; MGH COVID-19 Collection & Processing Team, ; Maus, M. V.
10.1101/2021.05.03.442455 — immunology — Posted on 2021-05-03
4252 Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity
Mazzarella, L.; Santoro, F.; Ravasio, R.; Massa, P.; Rodighiero, S.; Gaviln, E.; Romanenghi, M.; Duso, B.; Bonetti, E.; Pallavi, R.; Trastulli, D.; Pallavicini, I.; Gentile, C.; Leonardi, T.; Buttinelli, G.; Pasqualato, S.; Di Martino, A.; Fedele, G.; Schiavoni, I.; Stefanelli, P.; Meroni, G.; Steinkuhler, C.; Fossati, G.; Minucci, S.; Pelicci, P. G.
10.1101/2021.05.02.441948 — immunology — Posted on 2021-05-03
4253 SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection
Khaddaj-Mallat, R.; Aldib, N.; Paquette, A.-S.; Ferreira, A.; Lecordier, S.; Bernard, M.; Saghatelyan, A.; ElAli, A.
10.1101/2021.04.30.442194 — neuroscience — Posted on 2021-05-03
4256 LY-CoV1404 potently neutralizes SARS-CoV-2 variants
Westendorf, K.; Zentelis, S.; Foster, D.; Vaillancourt, P.; Wiggin, M.; Lovett, E.; Hendle, J.; Pustilnik, A.; Sauder, J. M.; Kraft, L.; Hwang, Y.; Siegel, R. W.; Chen, J.; Heinz, B. A.; Higgs, R. E.; Kalleward, N.; Jepson, K.; Goya, R.; Smith, M. A.; Collins, D. W.; Pellacani, D.; Xiang, P.; de Puyraimond, V.; Ricicova, M.; Devorkin, L.; Pritchard, C.; O'Neill, A.; Cohen, C.; Dye, J.; Huie, K. I.; Badger, C. V.; Kobasa, D.; Audet, J.; Freitas, J. J.; Hassanali, S.; Hughes, I.; Munoz, L.; Palma, H. C.; Ramamurthy, B.; Cross, R. W.; Geisbert, T. W.; Lanz, I.; Anderson, L.; Sipahimalani, P.; Cor
10.1101/2021.04.30.442182 — immunology — Posted on 2021-05-03
4261 The ALOG family members OsG1L1 and OsG1L2 regulate inflorescence branching in rice
Franchini, E.; Beretta, V. M.; Ud Din, I.; Lacchini, E.; Van den Broeck, L.; Sozzani, R.; Orozco-Arroyo, G.; Adam, H.; Jouannic, S.; Gregis, V.; Kater, M. M.
10.1101/2021.05.03.442460 — developmental biology — Posted on 2021-05-03
4263 A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state
Gupta, N.; Yakhou, L.; Richard Albert, J.; Miura, F.; Ferry, L.; Kirsh, O.; Laisne, M.; Yamaguchi, K.; Domrane, C.; Bonhomme, F.; Sarkar, A.; Delagrange, M.; Ducos, B.; Greenberg, M. V. C.; Cristofari, G.; Bultmann, S.; Ito, T.; Defossez, P.-A.
10.1101/2021.05.03.442415 — molecular biology — Posted on 2021-05-03
4266 Soils and sediments host novel archaea with divergent monooxygenases implicated in ammonia oxidation
Diamond, S.; Lavy, A.; Crits-Christoph, A.; Matheus Carnevali, P. B.; Sharrar, A.; Williams, K. H.; Banfield, J. F.
10.1101/2021.05.03.442362 — microbiology — Posted on 2021-05-03
4267 Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes
Armitage, L. H.; Stimpson, S. E.; Santostefano, K. E.; Sui, L.; Ogundare, S. O.; Newby, B. N.; Castro-Gutierrez, R.; Huber, M. K.; Taylor, J. P.; Sharma, P.; Radichev, I.; Perry, D. J.; Fredette, N.; Savinov, A.; Terada, N.; Brusko, T. M.; Wallet, M. A.; Russ, H.; Chen, J.; Egli, D.; Mathews, C. E.
10.1101/2021.05.03.441837 — immunology — Posted on 2021-05-03
4269 DELAY OF GERMINATION 6, encoding the ANAC060 transcription factor, inhibits seed dormancy
Song, S.; He, H.; Guhl, K.; Veldkamp, M. v. B.; Buijs, G.; Willems, L. A. J.; Bentsink, L.
10.1101/2021.05.03.442418 — plant biology — Posted on 2021-05-03
4270 A DUF1068 protein acts as a pectin biosynthesis scaffold and maintains Golgi morphology and cell adhesion in Arabidopsis.
Lathe, R. S.; McFarlane, H. E.; Khan, G.; Ebert, B.; Ramirez-Rodriguez, E. A.; Noord, N.; Bhalerao, R.; Persson, S.
10.1101/2021.05.03.442108 — plant biology — Posted on 2021-05-03
4272 The oncogenic Runx3-Myc axis defines p53-deficient osteosarcomagenesis
Otani, S.; Date, Y.; Ueno, T.; Ito, T.; Kajikawa, S.; Omori, K.; Taniuchi, I.; Umeda, M.; Komori, T.; Toguchida, J.; Ito, K.
10.1101/2021.05.03.442316 — cancer biology — Posted on 2021-05-03
4275 Multi-omics prediction of oat agronomic and seed nutritional traits across environments and in distantly related populations
Hu, H.; Campbell, M. T.; Yeats, T. H.; Zheng, X.; Runcie, D. E.; Covarrubias-Pazaran, G.; Corey, B.; Yao, L.; Caffe, M.; Gutierrez, L.; Smith, K. P.; Tanaka, J.; Hoekenga, O. A.; Sorrells, M. E.; Gore, M. A.; Jannink, J.-L.
10.1101/2021.05.03.442386 — genetics — Posted on 2021-05-03
4278 Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin
Byles, V.; Cormerais, Y.; Kalafut, K.; Barrera, V.; Hughes Hallett, J. E.; Ho Sui, S.; Asara, J. M.; Adams, C. M.; Hoxhaj, G.; Ben-Sahra, I.; Manning, B. D.
10.1101/2021.05.02.442369 — cell biology — Posted on 2021-05-03
4281 Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death
Margreiter, M. A.; Witzenberger, M.; Wasser, Y.; Davydova, E.; Janowski, R.; Sobisch, C.; Metz, J.; Poma, B.; Paolomino-Hernandez, O.; Shah, J.; Schulz, J. B.; Niessing, D.; Voigt, A.; Rossetti, G.
10.1101/2021.05.03.442419 — molecular biology — Posted on 2021-05-03
4282 Metagenomics and Metatranscriptomics Reveal Pathway of 3-Chloroaniline Degradation in Wastewater Reactors
Seshan, H.; Santillan, E.; Constancias, F.; Chandra Segaran, U. S.; Williams, R. B. H.; Wuertz, S.
10.1101/2021.05.02.442374 — microbiology — Posted on 2021-05-03
4283 Sex-specific multi-level 3D genome dynamics in the mouse brain
Rocks, D.; Shukla, M.; Finnemann, S. C.; Kalluchi, A.; Rowley, M. J.; Kundakovic, M.
10.1101/2021.05.03.442383 — neuroscience — Posted on 2021-05-03
4285 Basal forebrain cholinergic neurons are part of the threat memory engram
Rajebhosale, P.; Ananth, M. R.; Crouse, R. B.; Jiang, L.; Lopez- Hernandez, G.; Arty, C.; Wang, S.; Jone, A.; Zhong, C.; Desai, N.; Li, Y.; Picciotto, M.; Role, L. W.; Talmage, D. A.
10.1101/2021.05.02.442364 — neuroscience — Posted on 2021-05-03
4287 Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke
Becktel, D. A.; Zbesko, J. C.; Frye, J. B.; Chung, A. G.; Hayes, M.; Calderon, K.; Grover, J. W.; Li, A.; Garcia, F. G.; Tavera-Garcia, M. A.; Schnellmann, R. G.; Wu, H.-J. J.; Nguyen, T.-V. V.; Doyle, K. P.
10.1101/2021.05.03.442388 — neuroscience — Posted on 2021-05-03
4290 Correction of amblyopia in cats and mice after the critical period
Fong, M.-f.; Duffy, K. R.; Leet, M. P.; Candler, C. T.; Bear, M. F.
10.1101/2021.05.03.442423 — neuroscience — Posted on 2021-05-03
4292 Pipeline for 4D whole-brain microscopy preprocessing and analysis.
Bonapersona, V.; Schuler, H.; Damsteeg, R. D.; Adolfs, Y.; Pasterkamp, R. J.; van den Heuvel, M. P.; Joels, M.; Sarabdjitsingh, R. A.
10.1101/2021.05.03.442441 — neuroscience — Posted on 2021-05-03
4294 Neuronal genetic rescue normalizes brain network dynamics in a lysosomal storage disorder despite persistent storage accumulation
Ahrens-Nicklas, R. C.; Tecedor, L.; Hall, A. H.; Kane, O.; Chung, R. J.; Lysenko, E.; Marsh, E. D.; Davidson, B. L.
10.1101/2021.05.03.442437 — neuroscience — Posted on 2021-05-03
4298 Muscle fatigue revisited - Insights from optically pumped magnetometers
Sometti, D.; Semeia, L.; Chen, H.; Dax, J.; Kronlage, C.; Baek, S.; Kirchgaessner, M.; Romano, A.; Heilos, J.; Staber, D.; Oppold, J.; Righetti, G.; Middelmann, T.; Braun, C.; Broser, P.; Marquetand, J.
10.1101/2021.05.03.442396 — physiology — Posted on 2021-05-03
4299 Scarf: A toolkit for memory efficient analysis of large-scale single-cell genomics data
Dhapola, P.; Rodhe, J.; Olofzon, R.; Bonald, T.; Erlandsson, E.; Soneji, S.; Karlsson, G.
10.1101/2021.05.02.441899 — bioinformatics — Posted on 2021-05-03
4301 Reconstructing co-dependent cellular crosstalk in lung adenocarcinoma using REMI
Yu, A.; Li, Y.; Li, I.; Yeh, C.; Chiou, A.; Ozawa, M. G.; Taylor, J.; Plevritis, S. K.
10.1101/2021.05.02.440071 — bioinformatics — Posted on 2021-05-03
4302 Emu: Species-Level Microbial Community Profiling for Full-Length Nanopore 16S Reads
Curry, K. D.; Wang, Q.; Nute, M. G.; Tyshaieva, A.; Reeves, E.; Soriano, S.; Graeber, E.; Finzer, P.; Mendling, W.; Wu, Q.; Savidge, T.; Villapol, S.; Dilthey, A.; Treangen, T. J.
10.1101/2021.05.02.442339 — bioinformatics — Posted on 2021-05-03
4303 Classification of non-coding variants with high pathogenic impact
Moyon, L.; Berthelot, C.; Louis, A.; Nguyen, N. T. T.; Roest Crollius, H.
10.1101/2021.05.03.442347 — bioinformatics — Posted on 2021-05-03
4304 3D confinement regulates stem cell fate
Dudaryeva, O. Y.; Bucciarelli, A.; Bovone, G.; Jaydev, S.; Broguiere, N.; Al-Bayati, M.; Lutolf, M.; Tibbitt, M. W.
10.1101/2021.05.02.442094 — bioengineering — Posted on 2021-05-03
4307 NOVA2 regulates neural circRNA biogenesis
Knupp, D.; Cooper, D. A.; Saito, Y.; Darnell, R. B.; Miura, P.
10.1101/2021.05.02.442201 — genomics — Posted on 2021-05-03
4308 Distribution of GOPC:ROS1 and other ROS1 fusions in glioma types
Sievers, P.; Stichel, D.; Sill, M.; Schrimpf, D.; Sturm, D.; Selt, F.; Ecker, J.; Miele, E.; Kranendonk, M. E. G.; Tops, B. B. J.; Kohlhof-Meinecke, P.; Beschorner, R.; Kramm, C. M.; Hasselblatt, M.; Reifenberger, G.; Capper, D.; Wesseling, P.; Milde, T.; Korshunov, A.; Witt, O.; Pfister, S. M.; Wick, W.; von Deimling, A.; Jones, D. T. W.; Sahm, F.
10.1101/2021.04.30.442173 — genomics — Posted on 2021-05-03
4309 yEvo: Experimental evolution in high school classrooms selects for novel mutations and epistatic interactions that impact clotrimazole resistance in S. cerevisiae.
Taylor, M. B.; Skophammer, R.; Warwick, A. R.; Boyer, J. M.; Students, y.; Walson, M.; Large, C. R. L.; Hickey, A. S.-M.; Rowley, P. A.; Dunham, M. J.
10.1101/2021.05.02.442375 — genetics — Posted on 2021-05-03
4311 Definitive Hematopoietic Stem Cells Minimally Contribute to Embryonic Hematopoiesis
Ulloa, B. A.; Habbsa, S. S.; Potts, K. S.; Lewis, A.; McKinstry, M.; Payne, S. G.; Flores, J.; Nizhnik, A.; Feliz Norberto, M.; Mosimann, C.; Bowman, T. V.
10.1101/2021.05.02.442359 — developmental biology — Posted on 2021-05-03
4312 Myosins generate contractile force and maintain organization in the cytokinetic contractile ring
McDargh, Z. A.; Wang, S.; Chin, H. F.; Thiyagarajan, S.; Karatekin, E.; Pollard, T. D.; O'Shaughnessy, B.
10.1101/2021.05.02.442363 — cell biology — Posted on 2021-05-03
4313 Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
Sethi, A.; Horne, C. R.; Fitzgibbon, C.; Wilde, K. L.; Davies, K. A.; Garnish, S. E.; Jacobsen, A. V.; Samson, A. L.; Hildebrand, J. L.; Wardak, A.; Czabotar, P. E.; Petrie, E. J.; Gooley, P. R.; Murphy, J. M.
10.1101/2021.05.03.442385 — cell biology — Posted on 2021-05-03
4316 SARS-CoV-2 20I/501Y.V1 variant in the hamster model
Cochin, M.; Luciani, L.; Touret, F.; Driouich, J. S.; Petit, P.-R.; Moureau, G.; Baronti, C.; Thirion, L.; Maes, P.; Boudewijns, R.; Neyts, J.; de Lamballerie, X.; Nougairede, A.
10.1101/2021.04.19.440435 — microbiology — Posted on 2021-05-03
4317 Linear causal filtering: definition and theory
Pascual-Marqui, R.; Biscay, R. J.; Bosch-Bayard, J. F.; Faber, P. L.; Achermann, P.; Kinoshita, T.; Kochi, K.
10.1101/2021.05.01.442232 — neuroscience — Posted on 2021-05-03
4319 Hypermethylation is associated with increased age in almond (Prunus dulcis D.A. Webb) accessions
D'Amico-Willman, K. M.; Niederhuth, C.; Anderson, E. S.; Gradziel, T. M.; Fresnedo Ramirez, J.
10.1101/2021.05.02.442365 — plant biology — Posted on 2021-05-03
4321 Oxidized alkyl phospholipids stimulate sodium transport in proximal tubules via PPAR-dependent pathway
Mizuno, T.; Satoh, N.; Horita, S.; Tsukada, H.; Sato, Y.; Kume, H.; Nangaku, M.; Nakamura, M.
10.1101/2021.05.02.442360 — physiology — Posted on 2021-05-03
4326 Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India
Cherian, S.; Potdar, V.; Jadhav, S.; Yadav, P.; Gupta, N.; Das, M.; Rakshit, P.; Singh, S.; Abraham, P.; Panda, S.; NIC team,
10.1101/2021.04.22.440932 — molecular biology — Posted on 2021-05-03
4327 A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine
Jangra, S.; Landers, J. J.; Rathnasinghe, R.; O'Konek, J. J.; Janczak, K. W.; Cascalho, M.; Kennedy, A. A.; Tai, A. W.; Baker, J. R.; Schotsaert, M.; Wong, P. T.
10.1101/2021.02.18.431484 — immunology — Posted on 2021-05-03
4329 Are indigenous territories effective natural climate solutions? A neotropical analysis using matching methods and geographic discontinuity designs.
Alejo, C.; Meyer, C.; Walker, W. S.; Gorelik, S. R.; Josse, C.; Aragon-Osejo, J. L.; Rios, S.; Augusto, C.; Llanos, A.; Coomes, O. T.; Potvin, C.
10.1101/2020.12.23.424126 — ecology — Posted on 2021-05-03
4333 Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencing
Jalloul, N.; Gomy, I.; Stokes, S. M.; Gusev, A.; Johnson, B. E.; Lindmen, N.; Macconaill, L.; Ganesan, S.; Garber, J. E.; Khiabanian, H.
10.1101/2021.04.14.439855 — bioinformatics — Posted on 2021-05-03
4335 AutoGGN: A Gene Graph Network AutoML Tool for Multi-Omics Research
Zhang, L.; Li, P.; Shen, W.; Xu, C.; Liu, D.; He, W.; Xu, Z.; Zhang, C.; Qiao, N.
10.1101/2021.04.30.442074 — bioinformatics — Posted on 2021-05-03
4336 Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with anti-inflammatory therapeutics
Nof, E.; Artzy-Schnirman, A.; Bhardwaj, S.; Sabatan, H.; Waisman, D.; Hochwald, O.; Gruber, M.; Borenstein-Levin, L.; Sznitman, J.
10.1101/2021.05.02.441992 — bioengineering — Posted on 2021-05-03
4340 Recombination-independent recognition of DNA homology for meiotic silencing in Neurospora crassa
Rhoades, N.; Nguyen, T.-S.; Witz, G.; Cecere, G.; Hammond, T.; Mazur, A. K.; Gladyshev, E.
10.1101/573907 — molecular biology — Posted on 2021-05-03
4341 Serotonin modulates learning content-specific neuroplasticity of functional brain networks
Klöbl, M.; Seiger, R.; Vanicek, T.; Handschuh, P.; Reed, M. B.; Spurny, B.; Ritter, V.; Godbersen, G. M.; Gryglewski, G.; Kraus, C.; Hahn, A.; Lanzenberger, R.
10.1101/2021.01.15.426779 — neuroscience — Posted on 2021-05-03
4344 The structural connectome constrains fast brain dynamics
Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.
10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-05-03
4345 Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function
Coni, S.; Falconio, F. A.; Marzullo, M.; Munafo, M.; Zuliani, B.; Mosti, F.; fatica, a.; ianniello, Z.; Bordone, R.; Agostinelli, E.; Macone, A.; Perna, A.; Matkovic, T.; Sigrist, S.; Silvestri, G.; Canettieri, G.; Ciapponi, L.
10.1101/2021.04.29.441910 — genetics — Posted on 2021-05-03
4346 Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating other proteins aggregation
Nowicka, U.; Chroscicki, P.; Stroobants, K.; Sladowska, M.; Turek, M.; Uszczynska-Ratajczak, B.; Kundra, R.; Goral, T.; Perni, M.; Dobson, C. M.; Vendruscolo, M.; Chacinska, A.
10.1101/2021.05.02.442342 — molecular biology — Posted on 2021-05-02
4348 The mechanisms of in vivo commensal control of Clostridioides difficile virulence
Girinathan, B. P.; DiBenedetto, N.; Worley, J. N.; Peltier, J.; Arrieta-Ortiz, M.; Immanuel, S. R. C.; Lavin, R.; Delaney, M. L.; Cummins, C.; Onderdonk, A. B.; Gerber, G. K.; Sonenshein, A. L.; Baliga, N.; Dupuy, B.; Bry, L.
10.1101/2020.01.04.894915 — microbiology — Posted on 2021-05-03
4352 Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations
Kafkova, A.; Tilokani, L.; Trcka, F.; Sramkova, V.; Vancova, M.; Bily, T.; Nebesarova, J.; Prudent, J.; Trnka, J.
10.1101/2021.03.09.434520 — biochemistry — Posted on 2021-05-03
4358 Multi-regional module-based signal transmission in the mouse visual cortex
Jia, X.; Siegle, J. H.; Durand, S.; Heller, G.; Ramirez, T.; Olsen, S. R.
10.1101/2020.08.30.272948 — neuroscience — Posted on 2021-05-03
4363 Bioptim, a Python framework for Musculoskeletal Optimal Control in Biomechanics
Michaud, B.; Bailly, F.; Charbonneau, E.; Ceglia, A.; Sanchez, L.; Begon, M.
10.1101/2021.02.27.432868 — bioengineering — Posted on 2021-05-03
4364 Inferring species compositions of complex fungal communities from long- and short-read sequence data
Hu, Y.; Irinyi, L.; Hoang, M. T. V.; Eenjes, T.; Graetz, A.; Stone, E.; Meyer, W.; Schwessinger, B.; Rathjen, J.
10.1101/2021.05.02.442318 — bioinformatics — Posted on 2021-05-02
4365 Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies
Gale-Grant, O.; Fenn-Moltu, S.; Franca, L.; Dimitrova, R.; Christiaens, D.; Cordero-Grande, L.; Chew, A.; Falconer, S.; Harper, N.; Price, A. N.; Hutter, J.; Hughes, E.; O'Muircheartaigh, J.; Rutherford, M.; Counsell, S.; Rueckert, D.; Nosarti, C.; Hajnal, J. V.; McAlonan, G.; Arichi, T.; Edwards, A. D.; Batalle, D.
10.1101/2021.05.02.442327 — neuroscience — Posted on 2021-05-02
4367 3D printed pacifier-shaped mouthpiece for fMRI-compatible gustometers
Munoz Tord, D.; Coppin, G.; Pool, E. R.; Mermoud, C.; Pataky, Z.; Sander, D.; Delplanque, S.
10.1101/2021.05.02.442330 — neuroscience — Posted on 2021-05-02
4368 Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke
Bice, A. R.; Xiao, Q.; Kong, J.; Yan, P.; Rosenthal, Z. P.; Kraft, A. W.; Smith, K. P.; Wieloch, T.; Lee, J.-M.; Culver, J.; Bauer, A. Q.
10.1101/2021.05.02.442355 — neuroscience — Posted on 2021-05-02
4369 Selective effects of biological and chronological age on the development of cognitive abilities in adolescence
Kovacs, I.; Kovacs, K.; Gervan, P.; Utczas, K.; Olah, G.; Troznai, Z.; Berencsi, A.; Szakacs, H.; Gombos, F.
10.1101/2021.05.02.442351 — neuroscience — Posted on 2021-05-02
4378 Arrestin-mediated Desensitization Enables Olfactory Discrimination in C. elegans
Merritt, D. M.; MacKay-Clackett, I.; Almeida, S. M. T.; Tran, C.; Ansar, S.; van der Kooy, D.
10.1101/2021.05.02.439367 — neuroscience — Posted on 2021-05-02
4381 Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats
Wang, W.; Schuette, P. J.; La-Vu, M. Q.; Tobias, B. C.; Ceko, M.; Kragel, P. A.; Reis, F. M.; Ji, S.; Sehgal, M.; Maesta-Pereira, S.; Chakerian, M.; Silva, A. J.; Canteras, N. S.; Wager, T.; Kao, J. C.; Adhikari, A.
10.1101/2021.05.02.442354 — neuroscience — Posted on 2021-05-02
4384 SeqScreen: Accurate and Sensitive Functional Screening of Pathogenic Sequences via Ensemble Learning
Balaji, A.; Kille, B.; Kappell, A.; Godbold, G. D.; Diep, M.; Elworth, L. R. A.; Qian, Z.; Albin, D.; Nasko, D. J.; Shah, N.; Pop, M.; Segarra, S.; Ternus, K.; Treangen, T. J.
10.1101/2021.05.02.442344 — bioinformatics — Posted on 2021-05-02
4386 The sperm protein SPACA4 is required for efficient fertilization in mice
Herberg, S.; Fujihara, Y.; Blaha, A.; Panser, K.; Kobayashi, K.; Larasati, T.; Novatchkova, M.; Theussl, C. H.; Olszanska, O.; Ikawa, M.; Pauli, A.
10.1101/2021.05.02.442348 — developmental biology — Posted on 2021-05-02
4391 Age-related declines in neural selectivity manifest differentially during encoding and recognition
Pauley, C.; Sommer, V. R.; Kobelt, M.; Keresztes, A.; Werkle-Bergner, M.; Sander, M. C.
10.1101/2021.04.29.441936 — neuroscience — Posted on 2021-05-02
4392 Predicting drug concentrations in PDMS microfluidic organ chips
Grant, J.; Özkan, A.; Oh, C.; Mahajan, G.; Prantil-Baun, R.; Ingber, D.
10.1101/2021.05.01.442248 — bioengineering — Posted on 2021-05-02
4395 The ASC Protein Controls the Severity of Systemic AA Amyloidosis in Mice
Losa, M.; Schuerch, P.; Carta, M. C.; Morales, I. C.; Frontzek, K.; Lysenko, V.; Lakkaraju, A. K.; Delic, M.; Schwarz, P.; Westermark, G. T.; Nilsson, K. P.; Nuvolone, M.; Theocharides, A. P.; Hornemann, S.; Aguzzi, A.
10.1101/2021.05.01.442282 — molecular biology — Posted on 2021-05-02
4398 Aminoglycoside antibiotics inhibit phage infection by blocking an early step of the phage infection cycle
Kever, L.; Hardy, A.; Luthe, T.; Huennefeld, M.; Gaetgens, C.; Milke, L.; Wiechert, J.; Wittmann, J.; Moraru, C.; Marienhagen, J.; Frunzke, J.
10.1101/2021.05.02.442312 — microbiology — Posted on 2021-05-02
4399 Vibrio cholerae biofilm dispersal regulator causes cell release from matrix through type IV pilus retraction
Singh, P. K.; Rode, D. K. H.; Buffard, P.; Nosho, K.; Bayer, M.; Jeckel, H.; Jelli, E.; Neuhaus, K.; Jimenez-Siebert, E.; Peschek, N.; Glatter, T.; Papenfort, K.; Drescher, K.
10.1101/2021.05.02.442311 — microbiology — Posted on 2021-05-02
4401 Protective pan-ebolavirus combination therapy by two multifunctional human antibodies
Gilchuk, P.; Murin, C. D.; Cross, R. W.; Ilinykh, P. A.; Huang, K.; Kuzmina, N.; Borisevich, V.; Agans, K. N.; Geisbert, J. B.; Carnahan, R. H.; Nargi, R. S.; Sutton, R. E.; Suryadevara, N.; Zost, S. J.; Bombardi, R. G.; Bukreyev, A.; Geisbert, T. W.; Ward, A. B.; Crowe, J. E.
10.1101/2021.05.02.442324 — immunology — Posted on 2021-05-02
4403 Left Hemisphere Dominance for Bilateral Kinematic Encoding in the Human Brain
Merrick, C. M.; Dixon, T. C.; Breska, A.; Lin, J. J.; Chang, E. F.; King-Stephens, D.; Laxer, K. D.; Weber, P. B.; Carmena, J. M.; Knight, R. T.; Ivry, R. B.
10.1101/2021.05.01.442295 — neuroscience — Posted on 2021-05-02
4407 Ventral Intermediate Nucleus structural connectivity-derived segmentation: anatomical reliability and variability
Bertino, S.; Basile, G. A.; Bramanti, A.; Ciurleo, R.; Tisano, A.; Anastasi, G. P.; Milardi, D.; Cacciola, A.
10.1101/2021.05.02.442321 — neuroscience — Posted on 2021-05-02
4408 A multisensory circuit for gating intense aversive experiences
Asok, A.; Leroy, F.; Parro, C.; de Solis, C. A.; Ford, L.; Fitzpatrick, M.; Kalmbach, A.; Neve, R.; Rayman, J. B.; Kandel, E.
10.1101/2021.05.01.441648 — neuroscience — Posted on 2021-05-02
4413 N-glycosylation of CD24 mediates cell motility but inhibits cell proliferation in colorectal cancer
Hakami, Z.; Raposo, T. P.; Alsulaiman, A.; Dalleywater, W.; Otifi, H.; Horobin, C.; Garrie, K.; Ilyas, M.
10.1101/2021.05.02.442315 — cancer biology — Posted on 2021-05-02
4414 Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts
Helms, E. J.; Berry, M. W.; Chaw, R. C.; DuFort, C. C.; Sun, D.; Onate, M. K.; Oon, C.; Bhattacharyya, S.; Sanford-Crane, H.; Horton, W.; Finan, J. M.; Sattler, A.; Makar, R.; Dawson, D. W.; Xia, Z.; Hingorani, S. R.; Sherman, M. H.
10.1101/2021.05.01.442252 — cancer biology — Posted on 2021-05-02
4416 DeepLIIF: Deep Learning-Inferred Multiplex ImmunoFluorescence for IHC Quantification
Ghahremani, P.; Li, Y.; Kaufman, A.; Vanguri, R.; Greenwald, N.; Angelo, M.; Hollmann, T. J.; Nadeem, S.
10.1101/2021.05.01.442219 — bioinformatics — Posted on 2021-05-02
4417 Structural and evolutionary analysis unveil functional adaptations in the promiscuous behavior of serum albumins
Velez Rueda, A. J.; Benitez, G. I.; Sommese, L. M.; Ardanaz, S. M.; Borucki, E. L.; Palopoli, N.; Iglesias, L. E.; Parisi, G.
10.1101/2021.05.01.442285 — bioinformatics — Posted on 2021-05-02
4419 RNA splicing programs define tissue compartments and cell types at single cell resolution
Olivieri, J. E.; Dehghannasiri, R.; Wang, P.; Jang, S.; de Morree, A.; Tan, S. Y.; Ming, J.; Wu, A. R.; Tabula Sapiens Consortium, ; Quake, S. R.; Krasnow, M. A.; Salzman, J.
10.1101/2021.05.01.442281 — bioinformatics — Posted on 2021-05-02
4420 Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with anti-inflammatory therapeutics
Nof, E.; Artzy-Schnirman, A.; Bhardwaj, S.; Sabatan, H.; Waisman, D.; Hochwald, O.; Gruber, M.; Borenstein-Levin, L.; Sznitman, J.
10.1101/2021.05.02.441992 — bioengineering — Posted on 2021-05-02
4421 Fine-scale spatial genetic structure across the species range reflects recent colonization of high elevation habitats in silver fir (Abies alba Mill.)
Major, E. I.; Höhn, M.; Avanzi, C.; Fady, B.; Heer, K.; Opgenoorth, L.; Piotti, A.; Popescu, F.; Postolache, D.; Vendramin, G. G.; Csillery, K.
10.1101/2021.05.02.442307 — evolutionary biology — Posted on 2021-05-02
4422 Linked machine learning classifiers improve species classification of fungi when using error-prone long-reads on extended metabarcodes
Eenjes, T.; Hu, Y.; Irinyi, L.; Hoang, M. T.; Smith, L.; Linde, C.; Meyer, W.; Stone, E.; Rathjen, J. P.; Mashford, B.; Schwessinger, B.
10.1101/2021.05.01.442223 — bioinformatics — Posted on 2021-05-02
4423 Meiotic budding yeast assemble bundled triple helices but not ladders
Ma, O. X.; Chong, W. G.; Lee, J. K. E.; Cai, S.; Siebert, C. A.; Howe, A.; Zhang, P.; Shi, J.; Surana, U.; Gan, L.
10.1101/746982 — cell biology — Posted on 2021-05-02
4424 The evolution of regulatory elements in the emerging promoter variant strains of HIV-1
Bhange, D.; Prasad, N.; Singh, S.; Prajapati, H. K.; Maurya, S. P.; Gopalan, B. P.; Nadig, S.; Chaturbhuj, D.; Boobalan, J.; Dinesha, T. R.; Ahamed, S. F.; Mehta, K.; Gohil, Y.; Balakrishnan, P.; Das, B. K.; Dias, M.; Gangakhedkar, R.; Mehendale, S.; Paranjape, R.; Saravanan, S.; Shet, A.; Solomon, S. S.; Thakar, M.; Ranga, U.
10.1101/2021.04.28.441760 — microbiology — Posted on 2021-05-02
4425 Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria
Barr, D. A.; Omollo, C. O.; Mason, M.; Koch, A.; Wilkinson, R. J.; Lalloo, D. G.; Meintjes, G.; Mizrahi, V.; Warner, D. F.; Davies, G. R.
10.1101/2021.05.01.442251 — microbiology — Posted on 2021-05-02
4427 Gait-level analysis of mouse open field behavior using deep learning-based pose estimation
Sheppard, K.; Gardin, J.; Sabnis, G.; Peer, A.; Darrell, M.; Deats, S.; Geuther, B.; Lutz, C. M.; Kumar, V.
10.1101/2020.12.29.424780 — animal behavior and cognition — Posted on 2021-05-02
4429 Protein secondary structure affects glycan clustering in native mass spectrometry
Yan, H.; Lockhauserbäumer, J.; Szekeres, G. P.; Mallagaray, A.; Creutznacher, R.; Taube, S.; Peters, T.; Pagel, K.; Uetrecht, C.
10.1101/2021.05.01.442239 — biophysics — Posted on 2021-05-01
4433 Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome
Mattis, J. H.; Somarowthu, A.; Goff, K. M.; Yom, J.; Sotuyo, N. P.; Mcgarry, L. M.; Feng, H.; Kaneko, K.; Goldberg, E. M.
10.1101/2021.05.01.442271 — neuroscience — Posted on 2021-05-01
4435 Activation of extrasynaptic kainate receptors drives hilar mossy cell activity
Ramos, C. C.; Lutzu, S.; Yamasaki, M.; Yanagawa, Y.; Watanabe, M.; Sakimura, K.; Tomita, S.; Castillo, P. E.
10.1101/2021.05.01.442200 — neuroscience — Posted on 2021-05-01
4436 Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein
Mao, X.; Gu, H.; Kim, D.; Kimura, Y.; Wang, N.; Xu, E.; Chen, C.; Zhang, S.; Jia, C.; Liu, Y.; Bian, H.; Karuppagounder, S.; Jia, L.; Ke, X.; Chang, M.; Lee, A.; Yang, J.; Rastegar, C.; Sriparna, M.; Ge, P.; Brahmachari, S.; Kim, S.; Zhang, S.; Shimoda, Y.; Saar, M.; Workman, C.; Vignali, D.; Muller, U.; Liu, C.; Ko, H.; Dawson, V.; Dawson, T.
10.1101/2021.05.01.442157 — neuroscience — Posted on 2021-05-01
4437 Evolutionary dynamics of circular RNAs in primates
Santos-Rodriguez, G.; Voineagu, I.; Weatheritt, R. J.
10.1101/2021.05.01.442284 — genomics — Posted on 2021-05-01
4449 Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells
Tamaoki, N.; Siebert, S.; Maeda, T.; Ha, N.-H.; Good, M. L.; Huang, Y.; Vodnala, S. K.; Mora, J. J. H.; Naoya, U.; Tisdale, J. F.; Sweeney, C. L.; Choi, U.; Brault, J.; Koontz, S.; Malech, H. L.; Yamazaki, Y.; Isonaka, R.; Goldstein, D. S.; Kimura, M.; Takebe, T.; Zou, J.; Stroncek, D. F.; Robey, P. G.; Kruhlak, M. J.; Restifo, N. P.; Vizcardo, R.
10.1101/2021.04.25.441298 — cell biology — Posted on 2021-05-01
4450 Molecular and cell biological analysis of SwrB in Bacillus subtilis
Kearns, D. B.; Phillips, A. M.; Sanchez, S.; Sysoeva, T.; Burton, B. M.
10.1101/2021.04.30.442225 — microbiology — Posted on 2021-05-01
4455 Crowdsourcing biocuration: the Community Assessment of Community Annotation with Ontologies (CACAO)
Ramsey, J.; McIntosh, B.; Renfro, D.; Aleksander, S. A.; LaBonte, S.; Ross, C.; Zweifel, A. E.; Liles, N.; Farrar, S.; Gill, J. J.; Erill, I.; Ades, S.; Berardini, T. Z.; Bennett, J. A.; Brady, S. M.; Britton, R.; Carbon, S.; Caruso, S. M.; Clements, D.; Dalia, R.; Defelice, M.; Doyle, E. L.; Friedberg, I.; Gurney, S. M.; Hughes, L.; Johnson, A.; Kowalski, J. M.; Li, D.; Lovering, R. C.; Mans, T. L.; McCarthy, F.; Moore, S. D.; Murphy, R.; Paustian, T. D.; Perdue, S.; Peterson, C. N.; Pruess, B. M.; Saha, M. S.; Sheehy, R. R.; Tansey, J. T.; Temple, L.; Thorman, A. W.; Trevino, S.; Vollmer, A.
10.1101/2021.04.30.440339 — bioinformatics — Posted on 2021-05-01
4456 Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation
Pyke, R. M.; Mellacheruvu, D.; Dea, S.; Abbott, C.; Zhang, S. V.; Phillips, N. A.; Harris, J.; Bartha, G.; Desai, S.; McClory, R.; West, J.; Snyder, M. P.; Chen, R.; Boyle, S. M.
10.1101/2021.04.30.442203 — bioinformatics — Posted on 2021-05-01
4458 ACTIVATION LOOP PHOSPHORYLATION OF A NON-RD RECEPTOR KINASE INITIATES PLANT INNATE IMMUNE SIGNALING
Bender, K. W.; Couto, D.; Kadota, Y.; Macho, A. P.; Sklenar, J.; Bjornson, M.; Petriello, A.; Font Farre, M.; Schwessinger, B.; Ntoukakis, V.; Stransfeld, L.; Jones, A. M. E.; Menke, F. L.; zipfel, c.
10.1101/2021.05.01.442257 — biochemistry — Posted on 2021-05-01
4459 Ultraspecific somatic SNV and indel detection in single neurons using primary template-directed amplification
Luquette, L. J.; Miller, M. B.; Zhou, Z.; Bohrson, C. L.; Galor, A.; Lodato, M. A.; Gawad, C.; West, J.; Walsh, C. A.; Park, P. J.
10.1101/2021.04.30.442032 — genomics — Posted on 2021-05-01
4460 A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank
Rocheleau, G.; Forrest, I. S.; Duffy, A.; Bafna, S.; Dobbyn, A.; Verbanck, M.; Won, H.-H.; Jordan, D. M.; Do, R.
10.1101/2021.04.30.441974 — genomics — Posted on 2021-05-01
4463 Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria
Barr, D. A.; Omollo, C. O.; Mason, M.; Koch, A.; Wilkinson, R. J.; Lalloo, D. G.; Meintjes, G.; Mizrahi, V.; Warner, D. F.; Davies, G. R.
10.1101/2021.05.01.442251 — microbiology — Posted on 2021-05-01
4464 EEG biomarkers of free recall
Kahana, M. J.; Katerman, B. S.; Keane, C.; Li, Y.; Pazdera, J. K.
10.1101/2021.04.30.442192 — neuroscience — Posted on 2021-05-01
4465 Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
Brault, V.; Nguyen, T. L.; Flores-Gutierrez, J.; Birling, M.-C.; Lalanne, V.; Meziane, H.; Manousopoulou, A.; Pavlovic, G.; Lindner, L.; Selloum, M.; Sorg, T.; Yu, E.; Garbis, S. D.; HERAULT, Y.
10.1101/2021.05.01.442242 — neuroscience — Posted on 2021-05-01
4468 Preserved motor memory in Parkinson's disease
Lahlou, S.; Gabitov, E.; Owen, L. L. W.; Shohamy, D.; Sharp, M.
10.1101/2021.04.30.441882 — neuroscience — Posted on 2021-05-01
4469 Minimal phrase composition revealed by intracranial recordings
Murphy, E.; Woolnough, O.; Rollo, P. S.; Roccaforte, Z. J.; Segaert, K.; Hagoort, P.; Tandon, N.
10.1101/2021.04.30.442171 — neuroscience — Posted on 2021-05-01
4473 Phylodynamic modelling of bacterial outbreaks using nanopore sequencing
Steinig, E.; Duchene, S.; Aglua, I.; Greenhill, A.; Ford, R.; Yoannes, M.; Jaworski, J.; Drekore, J.; Urakoko, B.; Poka, H.; Wurr, C.; Ebos, E.; Nangen, D.; Laman, M.; Manning, L.; Firth, C.; Smith, S.; Pomat, W.; Tong, S. Y. C.; Coin, L.; McBryde, E.; Horwood, P.
10.1101/2021.04.30.442218 — bioinformatics — Posted on 2021-05-01
4474 Linked machine learning classifiers improve species classification of fungi when using error-prone long-reads on extendedmetabarcodes
Eenjes, T.; Hu, Y.; Irinyi, L.; Hoang, M. T.; Smith, L.; Linde, C.; Stone, E.; Rathjen, J. P.; Mashford, B.; Schwessinger, B.
10.1101/2021.05.01.442223 — bioinformatics — Posted on 2021-05-01
4476 High-density spinal cord stimulation selectively activates lower urinary tract afferents
Jantz, M. K.; Gopinath, C.; Kumar, R.; Chin, C.; Wong, L.; Ogren, J. I.; Fisher, L. E.; McLaughlin, B. L.; Gaunt, R. A.
10.1101/2021.04.30.442206 — bioengineering — Posted on 2021-05-01
4478 In heart failure reactivation of RNA-binding proteins drives the transcriptome into a fetal state
D'Antonio, M.; Nguyen, J. P.; Arthur, T. D.; Matsui, H.; Donovan, M. K. R.; DAntonio-Chronowska, A.; Frazer, K. A.
10.1101/2021.04.30.442191 — genomics — Posted on 2021-05-01
4483 Oligomerization-driven MLKL ubiquitylation antagonises necroptosis
Liu, Z.; Dagley, L. F.; Shield-Artin, K. L.; Young, S. N.; Bankovacki, A.; Wang, X. S.; Tang, M. M.; Howitt, J. A.; Stafford, C.; Nachbur, U.; Fitzgibbon, C.; Garnish, S. E.; Webb, A. I.; Komander, D.; Murphy, J. M.; Hildebrand, J. M.; Silke, J.
10.1101/2021.05.01.442209 — molecular biology — Posted on 2021-05-01
4486 INfrastructure for a PHAge REference Database: Identification of large-scale biases in the current collection of phage genomes
Cook, R.; Brown, N.; Redgwell, T.; Rihtman, B.; Barnes, M.; Stekel, D. J.; Clokie, M.; Hobman, J.; Jones, M.; Millard, A. D.
10.1101/2021.05.01.442102 — microbiology — Posted on 2021-05-01
4491 TMEM184b is necessary for IL-31 induced itch
Larsen, E. G.; Cho, T. S.; McBride, M. L.; Feng, J.; Manivannan, B.; Madura, C.; Klein, N. E.; Wright, E. B.; Garcia-Verdugo, H. D.; Jarvis, C.; Khanna, R.; Hu, H.; Largent-Milnes, T. M.; Bhattacharya, M. R. C.
10.1101/2020.01.25.919902 — neuroscience — Posted on 2021-05-01
4494 Are narrow-ranging species doomed to extinction? Probable dramatic and generalised decline in future climate suitability of highly threatened species
Dubos, N.; Montfort, F.; Grinand, C.; Nourtier, M.; Deso, G.; Probst, J.-M.; Razafimanahaka, J. H.; Andriantsimanarilafy, R. R.; Rakotondrasoa, E. F.; Razafindraibe, P.; Jenkins, R.; Crottini, A.
10.1101/2021.03.30.437650 — ecology — Posted on 2021-05-01
4495 Size-dependent protein segregation creates a spatial switch for Notch signaling and function
Kwak, M.; Southard, K. M.; Kim, N. H.; Gopalappa, R.; Kim, W. R.; An, M.; Lee, H. J.; Kang, M. K.; Choi, S. H.; Farlow, J.; Georgakopoulos, A.; Robakis, N. K.; Seo, D.; Kim, H. B.; Kim, Y. H.; Cheon, J.; Gartner, Z. J.; Jun, Y.-w.
10.1101/2020.06.28.176560 — cell biology — Posted on 2021-05-01
4496 Evolutionary insights into a non-coding deletion of SARS-CoV-2 B.1.1.7
Yang, J.; Zhang, G.; Yu, D.; Cao, R.; Wu, X.; Ling, Y.; Pan, Y.-H.; Yi, C.; Sun, X.; Sun, B.; Zhang, Y.; Zhao, G.-P.; Li, Y.; Li, H.
10.1101/2021.04.30.442029 — evolutionary biology — Posted on 2021-05-01
4497 The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression
Ferguson, J.; Campos-Leon, K.; Pentland, I.; Stockton, J. D.; Günther, T.; Beggs, A.; Roberts, S.; Noyvert, B.; Parish, J. L.
10.1101/2021.04.30.442078 — microbiology — Posted on 2021-05-01
4498 A Method for Cost-Effective and Rapid Characterization of Genetic Parts
McManus, J. B.; Bernhards, C. B.; Sharpes, C. E.; Garcia, D. C.; Murray, R. M.; Cole, S. D.; Emanuel, P. A.; Lux, M. W.
10.1101/2021.04.30.440836 — synthetic biology — Posted on 2021-05-01
4499 Prediction of Whole-Cell Transcriptional Response with Machine Learning
Eslami, M.; Espah Borujeni, A.; Eramian, H.; Doost Hosseini, H.; Vaughn, M.; Gordon, D. B.; Gaffney, N.; Weston, M.; Becker, D.; Dorfan, Y.; Fonner, J.; Urruita, J.; Zheng, G.; Singer, J.; Cristofaro, A.; Maschhoff, P.; Voigt, C.; Clowers, K.; Corbet, C.; Stubbs, J.; Yeung, E.
10.1101/2021.04.30.442142 — bioinformatics — Posted on 2021-05-01
4500 Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease
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