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Archive, 2025-02

4 Site-1 Protease is a negative regulator of sarcolipin promoter activity
Brookheart, R. T.; Sharma, I.; Kelly, M. O.; Hanners, K.; Shin, E. S.; Mousa, M.; Ek, S.; Meyer, G.
10.1101/2025.02.25.639963 — molecular biology — Posted on 2025-02-28
7 Maternal low protein diet alters the development of reward circuits from childhood to adulthood by reshaping its function
Paradis, J.; Guillaume, C.; Frapin, M.; Meistermann, D.; Pagniez, A.; de Coppet, P.; amarger, V.; Parnet, P.; Paille, V.
10.1101/2025.02.28.639479 — neuroscience — Posted on 2025-02-28
8 In vivo tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity
Sigurdardottir, J.; Tournier, J.-D.; Bonthrone, A. F.; Batalle, D.; Christiaens, D.; Hutter, J.; Cordero-Grande, L.; Chew, A.; Nosarti, C.; Hajnal, J. V.; McAlonan, G.; Poston, L.; Rutherford, M.
10.1101/2025.02.28.640038 — neuroscience — Posted on 2025-02-28
11 Hepatic Metabolic Memory Triggered by AM Exposure to Glucagon Alters Afternoon Glucose Metabolism
Waterman, H. L.; Smith, M.; Farmer, B.; Yankey, K.; Howard, T.; Kraft, G.; Edgerton, D.; Cherrington, A.
10.1101/2025.02.25.639957 — physiology — Posted on 2025-02-28
13 Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.
Bai, J.-p.; Stankewich, M. C.; Wang, J.; Tan, W.; Zuo, Z.; Song, Q.; Khan, S.; Morrow, J.; Santos-Sacchi, J.; Navaratnam, D. S.
10.1101/2025.02.25.640135 — physiology — Posted on 2025-02-28
14 High levels of DNA replication initiation factors indicate ATR inhibitor sensitivity via excessive origin firing
Lumeau, A.; Pfuderer, P. L.; De Angelis, S.; Scarth, J. A.; Guscott, M. A.; Shaikh, N.; Copley, F. B.; Gerdes, H.; Alard, E. L.; Cutillas, P. R.; Mardakheh, F. K.; Boemo, M. A.; Forment, J. V.; McClelland, S. E.
10.1101/2025.02.27.640046 — cancer biology — Posted on 2025-02-28
15 VPS35/Retromer-dependent MT1-MMP regulation confers melanoma metastasis
Hao, Q.; Bai, Y.; Guan, R.; Dong, R.; Bai, W.; Hamdy, H.; Wang, L.; Meng, M.; Sun, Y.; Shen, J.; Sun, J.
10.1101/2025.02.25.640017 — cancer biology — Posted on 2025-02-28
17 Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium
Souery, W.; Wong, J.; Diaz, A. A.; Xu, K.; Xiao, X.; Liu, H.; Liu, G.; Gower, A. C.; Alekseyev, Y.; Billatos, E.; Lenburg, M. E.
10.1101/2025.02.26.639889 — bioinformatics — Posted on 2025-02-28
19 A high throughput investigation of the binding specificity of carbohydrate-binding modules for synthetic and natural polymers
Rennison, A. P.; Fernandez-Macgregor, J.; Melot, J.; Durbesson, F.; Tandrup, T.; Westh, P.; Vincentelli, R.; Moeller, M. S.
10.1101/2025.02.25.640029 — bioengineering — Posted on 2025-02-28
21 Evaluating a Standard Benchmark for Gene Prioritization: The InheriNext(R) Algorithm's Integration of Genomic and Phenotypic Information
Chang, J.; Li, K.; Kubal, M.; Tsai, E.; Hamby, A.; Thomson, N.; Sheridan, J.; Barfield, S.; Rutz, R.; Ong, F.; Feliciano, R.; Kahn, S.; Wu, S.
10.1101/2025.02.25.640147 — genomics — Posted on 2025-02-28
22 Linking differences in personality to demography in the wandering albatross
Van De Walle, J.; van Daalen, S.; patrick, s.; Barbraud, C.; Delord, K.; Weimerskirch, H.; Thorley, J.; jenouvrier, s.
10.1101/2025.02.27.639933 — ecology — Posted on 2025-02-28
23 Investigation of coronaviruses, paramyxoviruses and poxviruses in free-ranging anteaters and armadillos: a search for the unknown and zoonotic implications
Martins, N. B.; Alves, M. H.; De Navasquez, L. M. L.; Linhares, Y. S.; Caiaffa, M. G.; Soresini, G.; Kluyber, D.; Yogui, D. R.; Alves, A. C.; Lobo, A. C. M.; Catao-Dias, J. L.; Benavides, J. A.; Desbiez, A. L. J.; Brandao, P. E.; Hora, A. S. d.
10.1101/2025.02.26.640290 — molecular biology — Posted on 2025-02-28
24 Characterization and description of Clostridium filamentum ETTB, a novel gut bacterium with TLR5 modulating properties
Makki, K.; Martino, M. E.; Alberdi, A.; Aizpurua, O.; Quagliariello, A.; Olsson, L.; Clasen, S.; Jonsson, J.; Brolin, H.; Dwibedi, C.; Yang, G.; Favero, C.; Bergh, P.-o.; Schnupf, P.; Ley, R.; Khan, M.-T.; Tremaroli, V.; Backhed, F.
10.1101/2025.02.28.640726 — microbiology — Posted on 2025-02-28
25 A century-old museum sample reveals abandavirus with modern day presence in northernEuropean bats
Gieraths, U.; Beheim-Schwarzbach, J.; Pickin, M. J.; Beyer, A.; Begeman, L.; Hoffmann, B.; Schlottau, K.; Beer, M.; Ulrich, R. G.; Mueller, T.; Freuling, C. M.; Mauno, T.; van de Bildt, M.; Mols, V. C.; Corman, V. M.; Weber, F.; Jones, T. C.; Drosten, C.
10.1101/2025.02.28.640763 — microbiology — Posted on 2025-02-28
26 Evolution guided tolerance engineering of Pseudomonas putida KT2440 for production of the sustainable aviation fuel precursor isoprenol
Lim, H.; Srinivasan, A.; Menchavez, R.; Yunus, I. S.; Noh, M. H.; White, M.; Chen, Y.; Gin, J. W.; Palsson, B. O.; Lee, T. S.; Petzold, C. J.; Eng, T.; Mukhopadhyay, A.; Feist, A. M.
10.1101/2025.02.28.640801 — microbiology — Posted on 2025-02-28
27 Repeated administration of cannabidiol decreases splenic lymphocyte numbers in rats: involvement of CB2 receptors
Turkki, T.; Jankowski, M. M.; Glac, W.; Badtke, P.; Saito, V. M.; Swiergiel, A. H.; Ignatowska-Jankowska, B. M.
10.1101/2025.02.24.639985 — immunology — Posted on 2025-02-28
28 Genetically encoded protein oscillators for FM streaming of single-cell data
Rajasekaran, R.; Galateo, T. M.; Xu, Z.; Bolshakov, D. T.; Weix, E. W. Z.; Coyle, S. M.
10.1101/2025.02.28.640587 — synthetic biology — Posted on 2025-02-28
29 The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585
D'Agostino, P. M.; de Castro, R. R.; Uka, V.; Saurav, K.; Milzarek, T. M.; Sester, A.; Schneider, M. P.; Gulder, T. A.
10.1101/2025.02.26.640319 — synthetic biology — Posted on 2025-02-28
30 Treatment of STEC infection via CRISPR-Cas targeted cleavage of the Shiga toxin gene in animal models
Galtier, M.; Krawczyk, A.; Fuche, F. J.; Charpenay, L. H.; Stzepourginski, I.; Pignotti, S.; Arraou, M.; Terrasse, R.; Brödel, A. K.; Poquet, C.; Prevot, G.; Spadoni, D.; Buhot, B.; Munch, K.; Havranek, J.; Cardenas Ramirez, P.; Rouquette, M.; Decrulle, A.; Kerbarh, O.; Lieberman, E.; Bramorski, C.; Grienenberger, A.; Hessel, E. M.; Salzano, G.; Garry, D. J.; Leveau, A.; Duportet, X.; Bikard, D.; Fernandez-Rodriguez, J.
10.1101/2025.02.28.640725 — synthetic biology — Posted on 2025-02-28
32 Normothermic human kidney preservation drives iron accumulation and ferroptosis
de Haan, M. J. A.; Jacobs, M. E.; de Graaf, A. M. A.; van Scheppingen, R. H.; Derks, R. J. E.; de Vries, D. K.; Kers, J.; Alwayn, I. P. J.; van Kooten, C.; Sanchez-Lopez, E.; Giera, M.; Engelse, M. A.; Rabelink, T. J.
10.1101/2025.02.24.639914 — physiology — Posted on 2025-02-28
34 DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma
Pal Singh, S.; van den Beukel, M. D.; van Deventer, S.; Overdijk, M. B.; Roukens, G.; Santegoets, K. C. M.; Breij, E. C. W.; ter Beest, M.; van Spriel, A. B.
10.1101/2025.02.24.639899 — cancer biology — Posted on 2025-02-28
35 KG-Microbe - Building Modular and Scalable Knowledge Graphs for Microbiome and Microbial Sciences
Santangelo, B. E.; Caufield, J. H.; Reese, J.; Kliegr, T.; Hunter, L. E.; Lozupone, C. A.; Hegde, H.; Joachimiak, M. P.
10.1101/2025.02.24.639989 — bioinformatics — Posted on 2025-02-28
39 Machine-Guided Dual-Objective Protein Engineering for Deimmunization and Therapeutic Functions
Wolfsberg, E.; Paul, J.-S.; Tycko, J.; Chen, B.; Bassik, M. C.; Bintu, L.; Alizadeh, A. A.; Gao, X. J.
10.1101/2025.02.24.639918 — bioengineering — Posted on 2025-02-28
41 Intracellular Mannanases Sustain Matrix Polysaccharide Biosynthesis
Jacobson, T.; Edwards, M.; Qiande, M.; Robert, M.; Moncrieff, J.; Voiniciuc, C.
10.1101/2025.02.25.640093 — biochemistry — Posted on 2025-02-28
43 Preclinical evaluation of the efficacy of α-Difluoromethylornithine and Sulindac against SARS-CoV-2 infection
Ignatenko, N. A.; Trinh, H.; Wagner, A. M.; Gerner, E. W.; Bime, C.; Hsu, C.-H.; Besselsen, D. G.
10.1101/2025.02.26.640194 — cell biology — Posted on 2025-02-28
44 Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest
Danesh, S.; Khan, F.; Chopko, T.; Lee, A.; Huo, R.; Lu, S.; Tam, V.; Safi, J. P.; Gao, W.; Todd, A.; Pagani, F. D.; Maleszewski, J. J.; Schaff, H. V.; Friedman, P. A.; Oral, H.; Metra, M.; Pitt, B.; Lei, I.; Tang, P. C.
10.1101/2025.02.24.639999 — molecular biology — Posted on 2025-02-28
45 Kinetic control of mammalian transcription elongation
Wang, Y.; Chen, X.; Kuemmecke, M.; Watters, J. W.; Cohen, J. E.; Xu, Y.; Liu, S.
10.1101/2025.02.24.639907 — molecular biology — Posted on 2025-02-28
46 Pixel intensity of wing photos used to predict age of Anopheles gambiae caught during the RIMDAMAL II clinical trial
Pugh, G.; Sougue, E.; Burton, T. A.; Yoe, R.; Gray, L. I.; Hephaestus, B.; Some, A.; Viden, B.; Parikh, S.; Some, A. F.; Dabire, R. K.; Foy, B. D.
10.1101/2025.02.27.640698 — microbiology — Posted on 2025-02-28
47 The cerebrospinal fluid virome in people with HIV: links to neuroinflammation and cognition
Trunfio, M.; Scutari, R.; Fox, V.; Vuaran, E.; Dastgheyb, R. M.; Fini, V.; Granaglia, A.; Balbo, F.; Tortarolo, D.; Bonora, S.; Perno, C. F.; Di Perri, G.; Alteri, C.; Calcagno, A.
10.1101/2025.02.28.640732 — microbiology — Posted on 2025-02-28
49 Lactuchelins: New lipopeptide siderophores from Pseudomonas lactucae inhibit Xanthomonas campestris pv. campestris 8004
Chesneau, G.; Noel, A.; Breard, D.; Boulanger, A.; Briand, M.; Bonneau, S.; Price, M.; Liu, Y.; Hendrickson, A.; Nielsen, T.; Sarniguet, A.; Guilet, D.; Arkin, A.; Lui, L.; BARRET, M.
10.1101/2025.02.28.640635 — microbiology — Posted on 2025-02-28
50 Attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor
Sumner, R. P.; Eke, L.; Hernaez, B.; Hood, A. J.; Sancheira Freitas, T.; Ashby, H.; Ellis, A.; Petit, M.; Lant, S.; Stokes, I.; Parija, P.; Alonso, I.; Alvarez-de Miranda, F. J.; Unanue, A. R.; Charleston, B.; Smith, G. L.; Ulaeto, D. O.; Alcami, A.; Maluquer de Motes, C.
10.1101/2025.02.27.640535 — microbiology — Posted on 2025-02-28
52 Detection of Paracoccus yeei in Spontaneous Bacterial Peritonitis using Rapid, Long Read Sequencing
Safaei, N.; Deng, Z.-L.; Ohlendorf, V.; Junk, B.; Sedlacek, L.; Kay, G. L.; O'Grady, J.; Debarry, J.; Ruppe, E.; Cornberg, M.; Maasoumy, B.; McHardy, A. C.
10.1101/2025.02.28.640566 — microbiology — Posted on 2025-02-28
53 First worldwide detection of blaIMP-15 in Stenotrophomonas maltophilia isolated from a patient in Lebanon.
Jabbour, Z. C.; Gerges, J. R.; Hussein, H. M.; Barada, S. B.; Hamadeh, L.; Mahfouz, R.; Kanafani, Z.; Matar, G. M.; Abou Fayad, A.
10.1101/2025.02.28.640784 — microbiology — Posted on 2025-02-28
54 Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory control
Mokhtari, T.; Taheri, M. N.; Akhlaghi, S.; Aryannejad, A.; Xiang, Y.; Mahajan, V.; Keshavarz F., K.; Kiani, A.; LoPresti, S. T.; LeGraw, R.; Whitehead, K. A.; Kiani, S.
10.1101/2025.02.24.639996 — immunology — Posted on 2025-02-28
55 Natural Killer Cell Receptor Signaling and Activation Depend on Cell Cycle Stages
Wethington, D.; Nayak, I.; Jensen, H.; Stewart, W. C.; Aguilar, O. A.; Chen, S.-Y.; Nolan, G. P.; Behbehani, G. K.; Lanier, L. L.; Das, J.
10.1101/2025.02.24.639882 — immunology — Posted on 2025-02-28
56 Microstructural and geochemical evidence offers a solution to the cephalopod cameral deposits riddle
Pohle, A.; Hoffmann, R.; Nützel, A.; Seuss, B.; Aubrechtova, M.; Kröger, B.; Stevens, K.; Immenhauser, A.
10.1101/2025.02.25.639475 — paleontology — Posted on 2025-02-28
57 Direct construction of sparse suffix arrays with Libsais
Van de Vyver, S.; Vande Moortele, T.; Dawyndt, P.; Mesuere, B.; Verschaffelt, P.
10.1101/2025.02.24.639849 — bioinformatics — Posted on 2025-02-28
58 WaveSeekerNet: Accurate Prediction of Influenza A Virus Subtypes and Host Source Using Attention-Based Deep Learning
Nguyen, H.-H.; Rudar, J.; Lesperance, N.; Vernygora, O.; Taylor, G. W.; Laing, C.; Lapen, D.; Leung, C. K.; Lung, O.
10.1101/2025.02.25.639900 — bioinformatics — Posted on 2025-02-28
60 Inflammation modulates lymph node biomechanics in a sex-dependent manner
Ramirez, A.; Sriram, V.; Abbouchi, Y.; Patolia, R.; Passaro, E.; Kaluzienski, M.; Maisel, K.
10.1101/2025.02.24.639945 — bioengineering — Posted on 2025-02-28
61 Discovery of The Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19
Unoh, Y.; Hirai, K.; Uehara, S.; Kawashima, S.; Nobori, H.; Sato, J.; Shibayama, H.; Hori, A.; Nakahara, K.; Kurahashi, K.; Takamatsu, M.; Yamamoto, S.; Zhang, Q.; Tanimura, M.; Dodo, R.; Maruyama, Y.; Sawa, H.; Watari, R.; Miyano, T.; Kato, T.; Sato, T.; Tachibana, Y.
10.1101/2025.02.26.639208 — biochemistry — Posted on 2025-02-28
64 Comprehensive identification of β-lactam antibiotic polypharmacology in Mycobacterium tuberculosis
Devlin, K. L.; Hutchinson, E.; Dearing, H. N.; Levine, S. R.; Reid, D. J.; Leach, D. T.; Griggs, L. H.; Lomas, G. X.; Gorham, L. J.; Wright, A. T.; Lamichhane, G.; Lin, V.; Beatty, K. E.
10.1101/2025.02.25.640225 — biochemistry — Posted on 2025-02-28
67 Dynamics of natural selection preceding human viral epidemics and pandemics.
Havens, J. L.; Pond, S. L. K.; Zehr, J.; Pekar, J. E.; Parker, E.; Worobey, M.; Andersen, K. G.; Wertheim, J. O.
10.1101/2025.02.26.640439 — evolutionary biology — Posted on 2025-02-28
70 Transcriptome-wide Identification of GlycoRNAs by Clier-seq Pipeline
Zhu, N.; Yang, Y.-L.; Liu, Y.-T.; Lu, Z.-Z.; Wang, Y.; Luo, Y.-L.; Meng, N.; Yuan, Y.; Zhong, Q.; Zeng, M.-S.
10.1101/2025.02.28.639800 — molecular biology — Posted on 2025-02-28
72 Epithelial-mesenchymal transition couples with cell cycle arrest at various stages
Hu, S.; Lu, Y.; Yu, G.; Zheng, Z.; Wang, W.; Ni, K.; Giri, A.; Zhang, J.; Zhang, Y.; Watanabe, K.; Yao, G.; Xing, J.
10.1101/2025.02.24.639880 — systems biology — Posted on 2025-02-28
73 Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects
Gupta, A.; Bhattacharya, T.; Pratihar, S.; Parvage, S.; Sharma, S. N.; Sarkar, A.; De, A.; Karmakar, S.; Dey, S.; Sinha, S.
10.1101/2025.02.24.639821 — physiology — Posted on 2025-02-28
75 Transferrin Receptor 1-targeted polymersomes therapy for Colorectal Cancer
Pina, A.; Mastrantuono, E.; Silva, M.; Barbieri, V.; Munoz-Lopez, J.; Battaglia, G.; Graca, L.; Matias, D.
10.1101/2025.02.24.639871 — cancer biology — Posted on 2025-02-28
82 Massively parallel assessment of designed protein solution properties using mass spectrometry and peptide barcoding
Feldman, D.; Sims, J. N.; Li, X.; Johnson, R.; Gerben, S.; Kim, D. E.; Richardson, C.; Koepnik, B.; Eisenach, H.; Hicks, D. R.; Yang, E.; Wicky, B. I. M.; Milles, L. F.; Bera, A.; Brackenbrough, E.; Joyce, E.; Sankaran, B.; Lubner, J. M.; Goreshnik, I.; Vafeados, D.; Allen, A.; Stewart, L.; MacCoss, M. J.; Baker, D.
10.1101/2025.02.24.639402 — biochemistry — Posted on 2025-02-28
83 Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes
Farhangdoost, N.; Liao, C.; Liu, Y.; Rochefort, D.; Pietrantonio, A.; Alda, M.; Dion, P. A.; Chaumette, B.; Khayachi, A.; Rouleau, G. A.
10.1101/2025.02.24.639480 — genomics — Posted on 2025-02-28
84 Enhancement of Therapeutic Transgene Insertion for Murine Phenylketonuria
Martinez, M.; Richards, D. Y.; Winn, S. R.; Baris, A. M.; Vonada, A.; Dudley, S.; Harper, L.; Harding, C. O.
10.1101/2025.02.24.639678 — genomics — Posted on 2025-02-28
85 The first chromosomal-level genome assembly of an allotetraploid oyster
Li, A.; Zhao, J.; Zhao, M.; Zhang, M.; Huo, M.; Deng, J.; Wang, L.; Wang, W.; Qi, H.; Li, Y.; Li, X.; Fu, J.; Guo, X.; Xu, Z.; Li, L.; Guo, X.; Zhang, G.
10.1101/2025.02.25.639704 — genomics — Posted on 2025-02-28
86 Landscapes of missense variant impact for human superoxide dismutase 1
Axakova, A.; Ding, M. X.; Cote, A. G.; Subramaniam, R.; Senguttuvan, V.; Zhang, H.; Weile, J.; Douville, S. V.; Gebbia, M.; Al-Chalabi, A.; Wahl, A.; Reuter, J.; Hurt, J.; Mitchell, A.; Fradette, S.; Andersen, P. M.; van Loggerenberg, W.; Roth, F. P.
10.1101/2025.02.25.640191 — genetics — Posted on 2025-02-28
92 Deconvoluting drug interactions based on M. tuberculosis physiologic processes:Transcriptional disaggregation of the BPaL regimen in vivo
Wynn, E. A.; Dide-Agossou, C.; Al Mubarak, R.; Rossmassler, K.; Hendrix, J.; Voskuil, M. I.; Obregon-Henao, A.; Lyons, M. A.; Robertson, G. T.; Moore, C. M.; Walter, N. D.
10.1101/2025.02.24.639926 — genomics — Posted on 2025-02-28
93 Single-cell mass cytometry maps the evolution of immune cell signatures predictive of acute graft-versus-host disease
Aries, J. A.; Charrot, S.; Theocharidis, S.; Meena, M.; Lee, W.-Y. J.; Correia, M. E.; Pennington, D. J.; Cavenagh, j.; Gribben, J. G.; Davies, J.
10.1101/2025.02.26.640331 — immunology — Posted on 2025-02-28
95 High-Parameter Spatial Multi-Omics through Histology-Anchored Integration
Liu, Y.; Wang, C.; Wang, Z.; Chen, L.; Li, Z.; Song, J.; Zou, Q.; Gao, R.; Qian, B.; Feng, X.; Guan, R.; Yuan, Z.
10.1101/2025.02.23.639721 — bioinformatics — Posted on 2025-02-28
98 Subjective salience ratings are a reliable proxy for physiological measures of arousal
Hadjis, G. E.; Atlas, L. Y.; Mouseli, P.; Sexton, C. A.; McAndrews, M. P.; Moayedi, M.
10.1101/2024.07.30.605866 — neuroscience — Posted on 2025-02-28
99 Trisomy 21 impairs synchronized activity and connectivity in developing human down syndrome cortical excitatory neuron networks
Peter, M.; Real, R.; Strano, A.; Robinson, H. P. C.; Smith, M. A.; Barnes, S. J.; de Paola, V.; Livesey, F. J.
10.1101/2024.12.27.630530 — neuroscience — Posted on 2025-02-28
106 Food supplementation with molybdenum complexes improves honey bee health
Floquet, S.; Fuior, A.; Colin-Duchevet, L.; Cebotari, V.; Noel, A.; Ribaud, I.; Gerard, I.; Garbuz, O.; Fregnaux, M.; Lopez, J.; Larcher, V.; Shestopalov, M. A.; Solovieva, A. O.; Pozmogova, T. N.; Gliga, O.; Railean, N.; Cochard, P.; Poirot, B.; Charistos, L.; Hatjina, F.; Somogyi, A.; Medjoubi, K.; Gaumer, S.; Gulea, A.; Toderas, I.; Sandoz, J.-C.
10.1101/2025.02.25.640117 — zoology — Posted on 2025-02-28
111 Lead exposure positively affects coccidia abundance in feral pigeons (Columba livia)
JEANTET, A.; Audebert, F.; Agostini, S.; Decenciere, B.; Gimeno, L.; Compain, T.; Federici, P.; Lorang, C.; Rozen-Rechels, D.; Gasparini, J.
10.1101/2025.02.25.640109 — ecology — Posted on 2025-02-28
114 A CDCA2 - MYC positive feedback loop controls cancer cells survival
Stamatiou, K.; Ligammari, L.; Bothota, M.; Tsavou, A.; Gokhan, E.; Ciciro, Y.; Zacarias Fluck, M. F.; Soucek, L.; Sala, A.; Vagnarelli, P.
10.1101/2025.02.28.640789 — cell biology — Posted on 2025-02-28
121 Path2Omics: Enhanced transcriptomic and methylation prediction accuracy from tumor histopathology
Hoang, D.-T.; Shulman, E. D.; Dhruba, S. R.; Nair, N. U.; Barman, R. K.; Lalchungnunga, H.; Singh, O.; Nasrallah, M. P.; Stone, E. A.; Aldape, K.; Ruppin, E.
10.1101/2025.02.26.640189 — bioinformatics — Posted on 2025-02-28
122 Class I histone deacetylases catalyze lysine lactylation
Tsusaka, T.; Najar, M. A.; Sharma, I.; Marcinkiewicz, M. M.; Crispim, C. V. D. S.; Snyder, N. W.; Burslem, G.; Goldberg, E. L.
10.1101/2025.02.25.640220 — biochemistry — Posted on 2025-02-28
127 Computational Translation of Mouse Models of Osteoarthritis Predicts Human Disease
Frost, M. R.; Ball, B. K.; Pendyala, M.; Douglas, S. R.; Brubaker, D. K.; Chan, D. D.
10.1101/2025.02.23.639777 — systems biology — Posted on 2025-02-28
132 Localizing electrophysiologic cue-reactivity within the nucleus accumbens guides deep brain stimulation for opioid use disorder
Qiu, L.; Nho, Y.; Seilheimer, R. L.; Kim, M. J.; Tufanoglu, A.; WILLIAMS, N.; Wexler, A.; David, O.; Millet, B.; Katherine, S. W.; Pesaran, B.; Evins, A. E.; Richardson, M.; Childress, A. R.; Halpern, C. H.
10.1101/2024.12.30.630822 — neuroscience — Posted on 2025-02-28
135 Charting the liver and lung metastatic niche in breast cancer
Sznurkowska, M. K.; Castro-Giner, F.; Krol, I.; Zhang, Y.; Ozimski, L. L.; D'Anna, I.; Ring, A.; Schwab, F. D.; Zhang, Y. W.; Zhou, J.; Saini, M.; Strittmatter, K.; Budinjas, S.; Vujanovic, M.; Kontarakis, Z.; Pontecorvi, G.; Albrecht, F.; Mertz, K. D.; Auray, G.; Giachino, C.; Taylor, V.; Gvozdenovic, A.; Kovacs, W.; Malanchi, I.; Frauchiger-Heuer, H.; Wicki, A.; Vetter, M.; Ligorio, M.; Aceto, N.
10.1101/2024.10.04.616491 — cancer biology — Posted on 2025-02-28
136 Molecular grammars of intrinsically disordered regions that span the human proteome
Ruff, K. M.; King, M. R.; Ying, A. W.; Liu, V.; Pant, A.; Lieberman, W. E.; Shinn, M. K.; su, x.; Kadoch, C.; Pappu, R. V.
10.1101/2025.02.27.640591 — bioinformatics — Posted on 2025-02-28
138 HCS-3DX, a next-generation AI-driven automated 3D-oid high-content screening system
Diosdi, A.; Toth, T.; Harmati, M.; Grexa, I.; Schrettner, B.; Hapek, N.; Kovacs, F.; Kriston, A.; Buzas, K.; Pampaloni, F.; Piccinini, F.; Horvath, P.
10.1101/2024.07.15.603536 — bioinformatics — Posted on 2025-02-28
141 Genomic factors limiting the diversity of Saccharomycotina plant pathogens
Lee, S. K.; West, C.; Opulente, D. A.; Harrison, M.-C.; Wolters, J. F.; Shen, X.-x.; Zhou, X.; Groenewald, M.; Hittinger, C. T.; Rokas, A.; LaBella, A. L.
10.1101/2025.02.27.640420 — genomics — Posted on 2025-02-28
143 Genomic basis of adaptation to serpentine soil in two Alyssum species shows convergence with Arabidopsis across 20 million years of divergence
Celestini, S.; Duchoslav, M.; Nezamivand-Chegini, M.; Gerchen, J.; Sramkova, G.; Wijfjes, R.; Krejcova, A.; Kuzmanovic, N.; Spaniel, S.; Schneeberger, K.; Yant, L.; Kolar, F.
10.1101/2025.02.27.640498 — evolutionary biology — Posted on 2025-02-28
145 Interactions between parasites within the host: helminth infection reduces lice abundance in feral pigeons (Columba livia)
JEANTET, A.; Audebert, F.; Agostini, S.; Decenciere, B.; Chereau, M.; Grasset, M.; Federici, P.; Rozen-Rechels, D.; Gasparini, J.
10.1101/2025.02.25.640130 — ecology — Posted on 2025-02-28
146 Rainwash eDNA to monitor tropical rainforest biodiversity
Zinger, L.; Benoiston, A.-S.; Cuenot, Y.; Leroy, C.; Louisanna, E.; Moreau, L.; Petitclerc, F.; Piatscheck, F.; Orivel, J.; Richard-Hansen, C.; Hansen-Chaffard, L.; Troispoux, V.; Boyer, F.; Chave, J.; Decaens, T.; Fouquet, A.; Pansu, J.; Raynaud, J.; Rougerie, R.; Sire, L.; Schimann, H.; Taberlet, P.; Iribar, A.
10.1101/2025.02.26.640397 — ecology — Posted on 2025-02-28
149 Müller glial Kir4.1 channel Dysfunction in APOE4-KI model of Alzheimer's disease
Abhyankar, S.; Xiao, Y.; Mahajan, N.; Luo, Q.; Cummins, T. R.; Oblak, A.; Lamb, B. T.; Corson, T.; Bhatwadekar, A. D.
10.1101/2025.02.26.640427 — neuroscience — Posted on 2025-02-28
151 Utilizing gene co-expression networks with the rat kidney TXG-MAPr tool to enhance safety assessment, biomarker identification and human translation
Kunnen, S. J.; Callegaro, G.; Sutherland, J. J.; Trairatphisan, P.; van Kessel, H.; Wijaya, L. S.; Chung, G.; Pye, K.; Goldstein, K. M.; Teague, C. R.; Fisher, C. P.; Saez-Rodriguez, J.; Brown, C.; Elmore, S. A.; Heinz-Taheny, K. M.; Stevens, J. L.; van de Water, B.
10.1101/2023.11.03.565444 — pharmacology and toxicology — Posted on 2025-02-28
153 RAS-PI3K Pathway in CAFs Shapes Physicochemical Properties of Tumor ECM to Impact Tumor progression
Cuesta, C.; Alcon-Perez, M.; Zheng, J.; Procel, N.; Cota, R. R.; Fennema, D.; Rosell, A.; Meson, D. L.; Martinez-Castedo, B.; Arafat, Y.; Sanz-Fraile, H.; Rajeeve, V.; Alonso, D.; Hynds, R. E.; Swanton, C.; Alcaraz, J.; Cutillas, P.; Reyes-Aldasoro, C. C.; Wang, H.; Castellano, E.
10.1101/2025.01.20.633776 — cancer biology — Posted on 2025-02-28
154 A breast tissue-specific epigenetic clock provides accurate chronological age predictions and reveals de-correlation of age and DNA methylation in tumor-adjacent and tumor samples
Garma, L. D.; Pernas, S.; Baz, D. V.; Garcia Campelo, R.; Terrasa, J.; Colomer, R.; Jimenez, D.; Vera Garcia, R.; Bermejo, B.; Gonzalez Santiago, S.; Quintela-Fandino, M.
10.1101/2025.02.21.639537 — cancer biology — Posted on 2025-02-28
155 Lipid-mediated mechanism of drug extrusion by a heterodimeric ABC exporter
Tang, Q.; Sinclair, M.; Bisignano, P.; Zhang, Y.; Tajkhorshid, E.; Mchaourab, H.
10.1101/2025.02.26.640354 — biophysics — Posted on 2025-02-28
158 Accurate and Reproducible Whole-Genome Genotyping for Bacterial Genomic Surveillance with Nanopore Sequencing Data
Prior, K.; Becker, K.; Brandt, C.; Cabal Rosel, A.; Dabernig-Heinz, J.; Kohler, C.; Lohde, M.; Ruppitsch, W.; Schuler, F.; Wagner-Lichtenegger, G. E.; Mellmann, A.
10.1101/2025.02.24.639834 — bioinformatics — Posted on 2025-02-28
161 Compulsive coping behaviour, which goal trackers do not develop, is exacerbated by chronic atomoxetine
Chernoff, C. S.; Belin-Rauscent, A.; Puaud, M.; Torrisi, S. A.; Fouyssac, M. S.; Nemeth, B.; Yu, C.; Higuera-Matas, A.; Jones, S.; Belin, D.
10.1101/2024.10.08.617254 — animal behavior and cognition — Posted on 2025-02-28
162 Genetic and Environmental Contributions to Epigenetic Aging Across Adolescence and Young Adulthood
Kuznetsov, D. V.; Liu, Y.; Schowe, A. M.; Czamara, D.; Instinske, J.; Pahnke, C. K. L.; Noethen, M. M.; Spinath, F. M.; Binder, E. B.; Diewald, M.; Forstner, A. J.; Kandler, C.; Moenkediek, B.
10.1101/2024.06.10.598273 — genomics — Posted on 2025-02-28
165 Urbanisation and habitat fragmentation favour thermophilic and monogynous ant species
Finand, B.; Monnin, T.; Bocquet, C.; Bultelle, A.; Federici, P.; Darmedru, L.; Gouffault, S.; Ledamoisel, J.; Loeuille, N.
10.1101/2025.02.25.640022 — ecology — Posted on 2025-02-28
166 Contact networks of small mammals highlight potential transmission foci of Lassa mammarenavirus.
Simons, D.; Goyal, R.; Bangura, U.; Gibb, R.; Rushton, B.; Sondufu, D.; Lamin, J.; Koninga, J.; Jimmy, M.; Dawson, M.; Lahai, J.; Ansumana, R.; Fichet-Calvet, E.; Watson-Jones, D.; Kock, R.; Jones, K. E.
10.1101/2025.02.25.639449 — ecology — Posted on 2025-02-28
167 Parkinson's Disease-Linked Kir4.2 Mutation R28C Leads to Loss of Ion Channel Function
Chen, X.; Finol-Urdaneta, R. K.; Chen, M.; Sykes, A.; Gao, B.; Adams, D. J.; Mellick, G. D.; Ma, L.
10.1101/2024.05.05.592599 — cell biology — Posted on 2025-02-28
170 Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
Mattioni, L.; Poggi, G.; Gallagher, C.; Becker, K.; Papic, M.; Engbers, J.; Koskinen, M.-K.; Abdollahzadeh, A.; Herzog, D. P.; Nardi, L.; Conrad, A.; Winterberg, S.; Schwarzbach, H.; Engelmann, J.; Lutz, B.; Waisman, A.; Hovatta, I.; Mittmann, T.; Schmeisser, M. J.; Mueller, M. B.; Treccani, G.
10.1101/2024.12.20.629639 — neuroscience — Posted on 2025-02-28
175 Enhancing plant broad-spectrum resistance through engineered pattern recognition receptors
Yang, Y.; Steidele, C. E.; Loeffelhardt, B.; Huang, L.; Nuernberger, T.; Ding, P.; Gust, A. A.
10.1101/2025.02.26.640353 — plant biology — Posted on 2025-02-28
177 Functional analysis of FW2.2-LIKE proteins in tomato: SlFWL5 regulates leaf size and morphology.
Beauchet, A.; Ehrard, L.; Boutaleb, L.; Rofidal, V.; Gonzalez, N.; Chevalier, C.; Bollier, N.
10.1101/2025.02.27.640525 — plant biology — Posted on 2025-02-28
178 Secreting salt glands constrain cuticle fracture to enhance desalination efficiency
Mai, M. H.; Rockwell, F. E.; Losada, J. M.; Nicholson, N.; Suo, Z.; Holbrook, N. M.
10.1101/2025.02.27.640653 — plant biology — Posted on 2025-02-28
181 Arabidopsis thaliana Iron Superoxide Dismutase FeSOD1 Protects ARGONAUTE 1 in a Copper-Dependent Manner
Tomassi, A. H.; Perea-Garcia, A.; Rodrigo, G. A.; Sanchez-Vicente, J.; Cisneros, A. E.; Olmos, M.; Andres-Borderia, A.; Lopez-Dolz, L.; Daros, J.-A.; Penarrubia, L.; Carbonell, A.
10.1101/2025.02.26.640378 — plant biology — Posted on 2025-02-28
182 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-02-28
183 Predicting the effect of CRISPR-Cas9-based epigenome editing
Batra, S. S.; Cabrera, A.; Spence, J. P.; Goell, J.; Anand, S. S.; Hilton, I.; Song, Y. S.
10.1101/2023.10.03.560674 — bioinformatics — Posted on 2025-02-28
184 Optimised Nanobody-based Quenchbodies for Enhanced Protein Detection
Cater, J. H.; Elsalamouny, N.; Mansour, G. H.; Hutchinson, S.; Mc Guinness, C.; Mueller, S. H.; Spinks, R. R.; Shanmugam, N.; Pichard-Kostuch, A.; Zahoransky, V.; Ghodke, H.; Ribezzi-Crivellari, M.; Yu, H.; van Oijen, A. M.; Griffiths, A. D.; Spenkelink, L. M.
10.1101/2024.03.27.582625 — bioengineering — Posted on 2025-02-28
185 Atomically accurate de novo design of antibodies with RFdiffusion
Bennett, N. R.; Watson, J. L.; Ragotte, R. J.; Borst, A. J.; See, D. L.; Weidle, C.; Biswas, R.; Yu, Y.; Shrock, E. L.; Ault, R.; Leung, P. J. Y.; Huang, B.; Goreshnik, I.; Tam, J.; Carr, K. D.; Singer, B.; Criswell, C.; Wicky, B. I. M.; Vafeados, D.; Garcia Sanchez, M.; Kim, H. M.; Vazquez Torres, S.; Chan, S.; Sun, S. M.; Spear, T.; Sun, Y.; OReilly, K.; Maris, J. M.; Sgourakis, N. G.; Melnyk, R. A.; Liu, C. C.; Baker, D.
10.1101/2024.03.14.585103 — bioengineering — Posted on 2025-02-28
187 Mechanistic basis of lineage restriction
Wu, B.; Lee, J. H.; Foshay, K. M.; Zhang, L.; Fernandes, C. J.; Gao, B.; Dou, X.; Zhang, C. Z.; Fan, G.; Xiao, B. X.; Lahn, B. T.
10.1101/2024.08.07.606262 — developmental biology — Posted on 2025-02-28
189 Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer
Hua, Y.; Duan, N.; Sun, C.; Yang, F.; Tian, M.; Sun, Y.; Zhao, S.; Gong, J.; Liu, Q.; Huang, X.; Liang, Y.; Fu, Z.; Li, W.; Yin, Y.
10.1101/2024.11.12.623302 — cancer biology — Posted on 2025-02-28
192 The Neuromusculoskeletal Modeling Pipeline: MATLAB-based Model Personalization and Treatment Optimization Functionality for OpenSim
Hammond, C. V.; Williams, S. T.; Vega, M. M.; Ao, D.; Li, G.; Salati, R. M.; Pariser, K. M.; Shourijeh, M. S.; Habib, A. W.; Patten, C.; Fregly, B. J.
10.1101/2024.10.30.620965 — bioengineering — Posted on 2025-02-28
198 ERC 2.0 - evolutionary rate covariation update provides more powerful inference of functional interactions across large phylogenies
Little, J. H.; Meyer, G. H.; Grover, A.; Francette, A. M.; Partha, R.; Arndt, K. M.; Smith, M.; Clark, N.; Chikina, M.
10.1101/2025.02.24.639970 — evolutionary biology — Posted on 2025-02-28
200 Contrasting genomic responses of hydrothermal vent animals and their symbionts to population decline after the Hunga volcanic eruption
Breusing, C.; Hauer, M. A.; Hughes, I. V.; Becker, J. S.; Casagrande, D.; Phillips, B. T.; Girguis, P. R.; Beinart, R. A.
10.1101/2025.02.24.639855 — evolutionary biology — Posted on 2025-02-28
205 Trait-space disparity in fish communities spanning 380 million years from the Late Devonian to present
Llewelyn, J. S.; Long, J. A.; Cloutier, R.; Clement, A. M.; Strona, G.; Saltre, F.; Lee, M. S. Y.; Choo, B.; Trinajstic, K.; Vanhaesebroucke, O.; Bradshaw, C. J. A.
10.1101/2024.08.29.610219 — evolutionary biology — Posted on 2025-02-28
207 Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition
Johnson, K. A.; Jones, F. K.; Ghadiali, R. S.; Lee, G.; Luke, T.-H. A.; Sweeney, M. D.; Moffitt, R. A.; Mamchaoui, K.; Ricci, E.; Young, I.; Pisconti, A.
10.1101/2025.02.26.640472 — cell biology — Posted on 2025-02-28
208 The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation
Yang, X.; He, F.; Porter, D. F.; Garbett, K.; Meyers, R. M.; Reynolds, D. L.; Duy, L. H. B.; Hong, A.; Ducoli, L.; Siprashvili, Z.; Lopez-Pajares, V.; Mondal, S.; Ko, L.; Jing, Y.; Tao, S.; Singal, B.; Sando, R.; Skiniotis, G.; Khavari, P. A.
10.1101/2025.02.19.639154 — cell biology — Posted on 2025-02-28
209 Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling
Li, J.; Tan, L. X.; Sun, B.; Griffin, N.; Niknezhad, S. V.; Yu, C.; Berthoin, L.; Cruz Pacheco, N.; Mohabbat, S.; Sinada, H.; Gaylord, E. A.; Chen, Y. T.; An, L.; Efraim, Y.; Bahney, C. S.; Lombaert, I. M. A.; Knox, S.
10.1101/2024.12.31.630834 — cell biology — Posted on 2025-02-28
210 Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Castranio, E. L.; Varghese, M.; Argyrousi, E. K.; Tripathi, K.; Soderberg, L.; Bresnahan, E.; Lerner, D.; Garretti, F.; Zhang, H.; van de Loo, J.; Stimpson, C.; Talty, R.; Glabe, C.; Levy, E.; Wang, M.; Ivkov, M.; Zhang, B.; Lannfelt, L.; Guerin, B.; Lubell, W.; Rahimipour, S.; Dickstein, D. L.; Gandy, S. E.; Arancio, O.; Ehrlich, M. E.
10.1101/2025.02.25.639746 — neuroscience — Posted on 2025-02-28
211 Human V4 size predicts crowding distance
Kurzawski, J. W.; Qiu, B. S.; Majaj, N. J.; Benson, N. C.; Pelli, D.; Winawer, J.
10.1101/2024.04.03.587977 — neuroscience — Posted on 2025-02-28
212 Functional identification of language-responsive channels in individual participants in MEG investigations
Huybrechts, M.; Bruffaerts, R.; Pongos, A.; Shain, C.; Lipkin, B.; Siegelman, M.; Wens, V.; Sjogard, M.; Blank, I.; Goldman, S.; De Tiege, X.; Fedorenko, E.
10.1101/2023.03.23.533424 — neuroscience — Posted on 2025-02-28
213 Subthalamic deep brain stimulation and chronic dopaminergic therapy enhance free-choice seeking in patients with Parkinson's disease
Bendetowicz, D.; Temiz, G.; Tempier, N.; Hainque, E.; Welter, M.-L.; Czernecki, V.; Lau, B.; Karachi, C.; Munuera, J.
10.1101/2023.01.04.522610 — neuroscience — Posted on 2025-02-28
215 Primate thalamic nuclei select abstract rules and shape prefrontal dynamics
Phillips, J. M.; Afrasiabi, M.; Kambi, N. A.; Redinbaugh, M. J.; Steely, S.; Johnson, E. R.; Cheng, X.; Fayyad, M.; Mohanta, S.; Caris, A.; Mikell, C. B.; Mofakham, S.; Saalmann, Y. B.
10.1101/2024.03.13.584871 — neuroscience — Posted on 2025-02-28
220 Knowledge Discovery in Datasets of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer
Resell, M.; Graarud, E. P.; Rabben, H.-L.; Sharma, A.; Hagen, L.; Hoang, L.; Skogaker, N. T.; Svensson, M. K.; Amrutkar, M.; Verbeke, C. S.; Batra, S. K.; Qvigstad, G.; WANG, T. C.; Rustgi, A. K.; Chen, D.; Zhao, C.-M.
10.1101/2025.02.23.639474 — systems biology — Posted on 2025-02-27
221 Identification of astrocytomas through serum protein fingerprint using MALDI-TOF MS and machine learning
Lazari, L. C.; Silva, J. M.; Donado, P. R. S.; Shinjo, S. M. O.; Fernandes, L. R.; Ieva, A. D.; Marie, S. K. N.; Palmisano, G.
10.1101/2025.02.21.639567 — systems biology — Posted on 2025-02-28
222 Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses
Gravino, M.; Mugford, S. T.; Pontiggia, D.; Joyce, J.; Drurey, C.; Prince, D. C.; Cervone, F.; De Lorenzo, G.; Hogenhout, S. A.
10.1101/2025.02.26.640334 — plant biology — Posted on 2025-02-28
225 PRPS activity tunes redox homeostasis in Myc-driven lymphoma
MacMillan, A. C.; Karki, B.; Yang, J.; Gertz, K. R.; Zumwalde, S.; Patel, J. G.; Czyzyk-Krzeska, M. F.; Meller, J.; Cunningham, J. T.
10.1101/2025.01.08.632009 — cancer biology — Posted on 2025-02-28
227 Targeted genome mining with GATOR-GC maps the evolutionary landscape of biosynthetic diversity
Cediel-Becerra, J. D. D.; Cumsille, A.; Guerra, S.; Ding, Y.; de Crecy-Lagard, V.; Chevrette, M. G.
10.1101/2025.02.24.639861 — bioinformatics — Posted on 2025-02-28
228 Cross-site harmonization of diffusion MRI data without matched training subjects
De Luca, A.; Swartenbroekx, T.; Seelaar, H.; van Swieten, J. C.; Cetin Karayumak, S.; Rathi, Y.; Pasternak, O.; Jiskoot, L. C.; Leemans, A.
10.1101/2024.05.01.591994 — bioinformatics — Posted on 2025-02-28
232 Differential Cellular Mechanisms Underlie Language and Executive Decline in Amyotrophic Lateral Sclerosis
Petrescu, J.; Roque, C. G.; Jackson, C.; Daly, A.; Kang, K.; Casel, O.; Leung, M.; Reilly, L.; Eschbach, J.; McDade, K.; Gregory, J. M.; Smith, C.; Phatnani, H.
10.1101/2025.02.26.640433 — genomics — Posted on 2025-02-27
233 From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development
Zhou, Q.; Liao, W.; Allegrini, A.; Rimfeld, K.; Wertz, J.; Morris, T.; Raffington, L.; Plomin, R.; Malanchini, M.
10.1101/2025.02.27.640510 — genomics — Posted on 2025-02-27
235 Repeatable phenotypic but not genetic response to selection on body size in the black soldier fly
Generalovic, T. N.; Zhou, W.; Zhao, L. C.; Leonard, S.; Warren, I. A.; Pipan, M.; Jiggins, C. D.
10.1101/2025.02.25.640052 — evolutionary biology — Posted on 2025-02-28
239 Keratin 15 promotes a progenitor cell statein basal keratinocytes of skin epidermis
Redmond, C. J.; Steiner, S. N.; Cohen, E.; Johnson, C. N.; Ozlu, N.; Coulombe, P. A.
10.1101/2025.02.27.640633 — developmental biology — Posted on 2025-02-27
241 Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation
Hu, J.; Huynh, D. T.; Dunn, D. E.; We, J.; Manriquez-Rodriguez, C.; Zhang, Q. E.; Hirschkorn, G. A.; Georgiou, G. R.; Hirata, T.; Myers, S. A.; Floyd, S. R.; Chi, J.-T. A.; Boyce, M.
10.1101/2025.02.27.640596 — cell biology — Posted on 2025-02-27
242 CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity
Wang, D.-M.; Yang, J.; Ansari, M. O.; Arbieva, Z.; Maienschein-Cline, M.; Natarajan, V.; Malik, A. B.; Tiruppathi, C.
10.1101/2025.02.27.640631 — cell biology — Posted on 2025-02-27
243 In-cell Structure and Variability of Pyrenoid Rubisco
Elad, N.; Hou, Z.; Dumoux, M.; Ramezani, A.; Perilla, J. R.; zhang, p.
10.1101/2025.02.27.640608 — cell biology — Posted on 2025-02-27
245 Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model
Heron, C.; Lemarcis, T.; Laguerre, O.; Bourgeois, B.; Thuilliez, C.; Valentin, C. L.; Dumesnil, A.; Valet, M.; Godefroy, D.; Schapman, D.; Riou, G.; Candon, S.; Derambure, C.; Zernecke, A.; Berard, C.; Dauchel, H.; Tardif, V.; Brakenhielm, E.
10.1101/2025.02.27.640360 — cell biology — Posted on 2025-02-27
246 Glucagon dysfunction in the liver induces hyperplasia of PP cells and the production of glucagon and pancreatic polypeptide double-positive cells
Nakagawa, Y.; Horii, T.; Fukunaka, A.; Sato, T.; Kobayashi, M.; Kitamura, T.; Hayashi, Y.; Nishimura, T.; Hatada, I.; Fujitani, Y.
10.1101/2025.02.27.640454 — cell biology — Posted on 2025-02-27
247 Reversible and Causal Epigenetic Information Loss in Liver Aging and Disease
Shtark, R. B.; Sagy, N.; Korenfeld, N.; Gal, M.; Goldstein, I. Z.; Bar, D. Z.
10.1101/2025.02.24.639802 — molecular biology — Posted on 2025-02-27
251 Human memory CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses
Stetsenko, V.; Gail, D. P.; Reba, S.; Suzart, V. G.; Sandhu, A. K.; Sette, A.; Dezfulian, M. H.; Arlehamn, C. S. L.; Carpenter, S. M.
10.1101/2025.02.23.639515 — immunology — Posted on 2025-02-27
252 CD11c+ CD8 T cells cause IFN-g-dependent autoimmune neuroinflammation that is restrained by PD-1 signaling.
Hwang, D.; Ishikawa, L. L. W.; Seyedsadr, M. S.; Jang, S.; Kasimoglu, E.; Rostami, A.; Zhang, G.-X.; Ciric, B.
10.1101/2025.02.23.639743 — immunology — Posted on 2025-02-27
255 Functional connectivity in the social perception pathway at birth is linked with attention to faces at 4 months
Chawarska, K.; Vernetti, A.; Sun, H.; Hampson, M.; Li, C.; Macari, S.; Powell, K.; Constable, R. T.; Chang, J.; Ment, L.; Scheinost, D.
10.1101/2025.02.27.640108 — neuroscience — Posted on 2025-02-27
257 Extracellular matrix proteolysis maintains synapse plasticity during brain development
Nakajo, H.; Cao, R.; Mula, S. A.; McKetney, J.; Silva, N. J.; Shah, M.; Rose, I. V. L.; Kampmann, M.; Swaney, D. L.; Kirst, C.; Molofsky, A. V.
10.1101/2025.02.27.640672 — neuroscience — Posted on 2025-02-27
258 IL-1R1 Blockade Enhances CD40 Agonist-Mediated Immune Responses but Fails to Increase Efficacy or Mitigate Hepatotoxicity in Pancreatic Cancer
Boda, A.; Bandey, I. N.; CHOWDHURY, S.; Aggarwal, S.; Reddy, M. v.; Fowlkes, N. W.; Roszik, J.; Curran, M. A.; Morris, V. K.; Kopetz, S.; Singh, M.
10.1101/2025.02.23.639774 — cancer biology — Posted on 2025-02-27
259 Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors.
Buhl, J. L.; Koelewijn, J.; De Munter, S.; Cruz, V. M.; Chin, D. J. K.; Zhang, B.; van Hoesel, M.; van Herk, N.; Paassen, I.; Nachataya, K.; Hofman, L.; de Boed, E.; Nierkens, S.; Kemmeren, P.; Cornel, A. M.; Wu, W.; Vandekerckhove, B.; Drost, J.; Janda, C. Y.
10.1101/2025.02.23.639405 — cancer biology — Posted on 2025-02-27
260 RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.
Flores Gonzalez, R. E.; Goncalves, C.; Wirasinghe, N.; Gaudeault St-Laurent, V.; Noda Ferro, J. M.; Dany-Coutant, K. S.; Mitchel, A.; Guettler, E.; Gonzalez Moreno, D. R.; Preston, S.; Cai, F.; Gagnon, N.; Jean, S.; Landreville, S.; Miller, W.; Del Rincon, S. V.
10.1101/2025.02.23.639782 — cancer biology — Posted on 2025-02-27
262 AggreBots: configuring CiliaBots through guided, modular tissue aggregation
Bhattaram, D.; Golestan, K.; Zhang, X.; Yang, S.; Gong, Z.; Brody, S. L.; Horani, A.; Webster-Wood, V. A.; Farimani, A. B.; Ren, X.
10.1101/2025.02.22.639695 — bioengineering — Posted on 2025-02-27
263 Astrocyte Transcriptomics in a Three-Dimensional Tissue-Engineered Rostral Migratory Stream
Grovola, M. R.; Purvis, E. M.; Garcia-Epelboim, A. D.; Krizman, E. N.; O'Donnell, J. C.; Cullen, D. K.
10.1101/2025.02.24.639941 — bioengineering — Posted on 2025-02-27
264 Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
Bourne, C. M.; Raniszewski, N. R.; Kulkarni, M.; Exconde, P. M.; Liu, S.; Yost, W.; Wrong, T. J.; Patio, R. C.; Mahale, A.; Kardhashi, M.; Shosanya, T.; Kambayashi, M.; Discher, B.; Brodsky, I. E.; Burslem, G.; Taabazuing, C. Y.
10.1101/2025.02.23.639785 — biochemistry — Posted on 2025-02-27
265 Luminos: open-source software for bidirectional microscopy
Itkis, D. G.; Brooks, F. P.; Davis, H. C.; Hotter, R.; Wong-Campos, J. D.; Qi, Y.; Jia, B. Z.; Howell, M.; Xiong, M.; Hayward, R. F.; Lee, B. H.; Wang, Y.; Perelman, R. T.; Cohen, A. E.
10.1101/2025.02.22.639658 — bioengineering — Posted on 2025-02-27
269 Hexanoic acid improves metabolic health in mice fed high-fat diet.
Ikeda, T.; Nishimoto, Y.; Ichikawa, D.; Matsunaga, T.; Kawauchi, A.; Kimura, I.
10.1101/2025.02.20.639216 — physiology — Posted on 2025-02-27
272 Modulation of intestinal bile acids influences colonic mucosal responses
Wortmann, E.; Groll, T.; Strigli, A.; Peuker, K.; Volet, C.; Arps, L.; Bernier-Latmani, R.; Zeissig, S.; Steiger, K.; Middelhoff, M.; Clavel, T.
10.1101/2025.02.21.639473 — physiology — Posted on 2025-02-27
273 An Fc-SPINK1 fusion protein inhibits pancreatic inflammation in a mouse model
Way, J. C.; Heid, D.; Theiss, M.; Noerrelykke, S.; Barck, L.; Burger, L.; Bredl, J. A.; Dobbertin, T.; Hoeflich, P.; Stadelmann, T.; Niopek, D.; Chan, K. R.; Graveline, A.; Vernet, A.; Sanchez-Ventura, M.; Silver, P. A.
10.1101/2025.02.21.639528 — pharmacology and toxicology — Posted on 2025-02-27
274 Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome
Peng, H.; Guo, Z.; Wang, W. L.; Yin, D.; Zou, S.; Thomas, A.; Ullman, B. R.; Maya, T.; Zhang, F.; Hong, S. Y.; Rao, A. V. S.; Wang, K.; Zhang, S.; Li, X.; Margolis, S. S.; Matsui, W. H.; Gocke, C. B.; Mao, Y.; Liu, J. O.
10.1101/2025.02.21.639179 — pharmacology and toxicology — Posted on 2025-02-27
276 Chemical enhancement of DNA repair in aging
Logarinho, E.; Macedo, J.; Silva, M. M.; Magalhaes, J. M.; Sousa-Soares, C.; Ala, M. I.; Galhardo, M.
10.1101/2025.02.21.639496 — pathology — Posted on 2025-02-27
281 Granular hydrogels as brittle yield stress fluids
Thompson, G. B.; Lee, J.; Kamani, K. M.; Flores-Velasco, N.; Rogers, S. A.; Harley, B.
10.1101/2025.02.22.639638 — bioengineering — Posted on 2025-02-27
282 Preventing peritendinous adhesions using lubricious supramolecular hydrogels
Meany, E.; Williams, C. M.; Song, Y. E.; Doulames, V. M.; Bailey, S. J.; Williams, S. C.; Jons, C. K.; Fox, P.; Appel, E.
10.1101/2025.02.22.639655 — bioengineering — Posted on 2025-02-27
286 Evolutionary history of the widespread association between placozoans and diverse Rickettsiales symbionts
Mankowski, A.; Leisch, N.; Hadfield, M. G.; Huettel, B.; Dubilier, N.; Gruber-Vodicka, H. R.
10.1101/2025.02.27.640636 — microbiology — Posted on 2025-02-27
288 Strain-level and phenotypic stability contrasts with plasmid and phage variability in water kefir communities
Somerville, V.; Sarton-Loheac, G.; de Bakker, V.; El Chazli, Y.; Kesner, L.; Ndiaye, M.; Garrido-Sanz, D.; Prasad, A.; Bonilla-Rosso, G.; Mazel, F.; Sentchilo, V.; Moineau, S.; Maurice, C. F.; Tamarelle, J.; Ulrich, E.; Engel, P.
10.1101/2025.02.27.640646 — microbiology — Posted on 2025-02-27
289 Identification of claudin-3 as an entry factor for rat hepacivirus
Tanaka, T.; Akaike, Y.; Kasai, H.; Yamashita, A.; Matsuura, Y.; Moriishi, K.
10.1101/2025.02.27.640490 — microbiology — Posted on 2025-02-27
291 "Paraxenoviridae", a putative family of ubiquitous marine bacteriophages with double-stranded RNA genomes
Yoshida, M.; Medvedeva, S.; Fukudome, A.; Wolf, Y. I.; Urayama, S.-i.; Nishimura, Y.; Takaki, Y.; Koonin, E. V.; Krupovic, M.; Nunoura, T.
10.1101/2025.02.27.640542 — microbiology — Posted on 2025-02-27
292 A prophage-encoded anti-phage defense system that prevents phage DNA packaging by targeting the terminase complex
Azulay, G.; Sigal, N.; Tzohar Rabinovich, K.; Koenigsfeld, D.; Stadnyuk, O.; Das, A.; Lisitzin, P.; Biderman, E.; Borovok, I.; Herskovits, A. A.
10.1101/2025.02.27.640495 — microbiology — Posted on 2025-02-27
293 Biological polyethylene deconstruction initiated by oxidation from DyP peroxidases
Klauer, R. R.; Hansen, D. A.; Schyns, Z. O. G.; Monteiro, L. O.; Moore-Ott, J. A.; Williams, M.; Tarr, M.; Singh, J.; Mhadeshwar, A.; Korley, L. T. J.; Solomon, K. V.; Blenner, M.
10.1101/2025.02.27.640435 — microbiology — Posted on 2025-02-27
295 Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system
Brinkley, D. M.; Bertolli, S. K.; Gallagher, L. A.; Tan, Y.; Motha de Silva, M.; Brockman, A.; Zhang, D.; Peterson, S. B.; Mougous, J. D.
10.1101/2025.02.26.640152 — microbiology — Posted on 2025-02-27
296 Identification of chemical features that influence mycomembrane permeation and antitubercular activity
Lepori, I.; Liu, Z.; Evbarunegbe, N.; Feng, S.; Brown, T. P.; Mane, K.; Shivangi, f.; Wong, M.; George, A.; Guo, T.; Dong, J.; Freundlich, J. S.; Im, W.; Green, A. G.; Pires, M. M.; Siegrist, M. S.
10.1101/2025.02.27.640664 — microbiology — Posted on 2025-02-27
297 Can Plitidepsin Be Used as an Antiviral Against RSV?
Estampes, C.; Fix, J.; Sourimant, J.; Sutto-Ortiz, P.; Richard, C.-A.; Decroly, E.; Galloux, M.; Eleouet, J.-F.
10.1101/2025.02.27.640515 — microbiology — Posted on 2025-02-27
301 Substantial contribution of in-situ produced bacterial lipids to the sedimentary lipidome
Ding, S.; Bale, N. J.; Cutmore, A.; von Meijenfeldt, F. A. B.; Schouten, S.; Sinninghe Damste, J.
10.1101/2025.02.27.640310 — microbiology — Posted on 2025-02-27
302 Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype.
Cheray, M.; Murgoci, A.-N.; Fragkopoulou, A.; Rodrigues, C. F. D.; Skandik, M.; Osman, A. M.; Hong, C.; Vazquez-Cabrera, G.; Friess, L.; Carlson, L.-M.; Kanatani, S.; Li, Y.; Damdimopoulos, A.; Uhlen, P.; Kamme, F.; Blomgren, K.; Joseph, B.
10.1101/2025.02.22.639606 — immunology — Posted on 2025-02-27
307 Immunization with peptide encapsulated within synthetic spores activates T cell responses and reduces tumor growth
D'Atri, D.; Tondini, E.; Machinandiarena, F.; Kong, M.; Mia, A.; Gallardo, D.; Tanner, K.; Hewitt, S.; Fitzgerald, D. J.; Ramamurthi, K. S.
10.1101/2025.02.27.640614 — cancer biology — Posted on 2025-02-27
308 Selective depletion of cancer cells with extrachromosomal DNA via lentiviral infection
Yi, E.; Gujar, A.; Zhao, D.; Suina, K.; Jin, X.; Pardon, K.; Yu, Q.; Kagermazova, L.; Boeke, J. D.; Henssen, A. G.; Verhaak, R.
10.1101/2025.02.22.639631 — cancer biology — Posted on 2025-02-27
310 Promoter-centric gene regulation in drug-resistant cancer
Kameswaran, V.; Paul, S.; Le, D.; Hoover, J.; Zhao, L. Y.; Guarnaccia, A. D.; Hagenbeek, T. J.; Lund, J. M.; Xavier-Magalhaes, A.; Shi, M.; Lau, J.; De Simone, M.; Liang, Y.; Dey, A.; Modrusan, Z.; Daniel, B.
10.1101/2025.02.20.639310 — cancer biology — Posted on 2025-02-27
311 Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1.
Boyer, T.; Blaye, C.; Chalopin, D.; Madery, M.; Boucher, J.; Moisand, A.; Giraud, J.; Theodoly-Lannes, A.; Peyraud, F.; Seeneevassen, L.; Klein, C.; Mebroukine, S.; Auriol, S.; Chaibi, A.; Zouine, A.; Alizadeh, D.; McGrogan, G.; Lamarthee, B.; Bonnotte, B.; Bonneil, E.; Roux, P. P.; Varon, C.; Domblides, C.; Larmonier, N.
10.1101/2025.02.21.639264 — cancer biology — Posted on 2025-02-27
312 Autocrine CXCL1-CXCR2 Signaling Mediates Leptomeningeal Resistance to Radiation Therapy
Osman, A.; Remsik, J.; Snyder, J.; Wijetunga, N. A.; Manoranjan, B.; Nobre, A. R.; Freret, M.; Guber, D.; Chabot, K.; Peidrafita-Ortiz, S.; Tong, X.; Wang, H.; Li, M. J.; Dunbar, A. J.; Levine, R. L.; Yang, J. T.; Boire, A.
10.1101/2025.02.20.639389 — cancer biology — Posted on 2025-02-27
313 CombiCTx: Screening diffusion gradients of anti-cancer drug combinations
Stelzl, C.; Lerma-Clavero, A.; Camenisch, S.; Simon, B.; Eriksson, O.; Degerstedt, O.; Lennernäs, H.; Heindryckx, F.; Kreuger, J.; O'Callaghan, P.
10.1101/2025.02.27.635465 — cancer biology — Posted on 2025-02-27
314 Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer
Jouines, C.; Lo Monaco, P.; Gaucherot, A.; Radermecker, J.; Isaac, C.; Bourdelais, F.; Monet, M.-A.; Meyer, M.; Chalabi-Dchar, M.; Nguyen Van Long, F.; Baillon, L.; Froment, C.; Marcoux, J.; Vanbelle, C.; Fenouil, T.; Durand, S.; Giraud, S.; Diaz, J.-J.; Marcel, V.; Catez, F.
10.1101/2025.02.23.639238 — cancer biology — Posted on 2025-02-27
315 LRP2 expression in melanoma is associated with a transitory cell state, increased T cell infiltration, and is upregulated by IFNγ signaling
Rasmussen, M. Q.; Bonnelykke-Behrndtz, M. L.; Merrild, C.; Tvilling, I.; Christensen, J. N.; Nielsen, M. M.; Georgsen, J. B.; Naumann, N.; Gudbergsson, J. M.; Etzerodt, A.; Pedersen, J. S.; Jenkins, R. W.; Degn, S. E.; Moestrup, S. K.; Schmidt, H.; Steiniche, T.; Madsen, M.
10.1101/2025.02.21.639443 — cancer biology — Posted on 2025-02-27
317 Dissection of Gαs and Hedgehog signaling crosstalk reveals therapeutic opportunities to target adenosine receptor 2b in Hedgehog-dependent tumors
Krantz, S.; Bell, B.; Lund, K.; Salinas Parra, N.; Ng, Y.; De Oliveira Rosa, N.; Mukhopadhyay, S.; St Croix, B.; Sarin, K. Y.; Weigert, R.; Raimondi, F.; Iglesias-Bartolome, R.
10.1101/2025.02.21.639530 — cancer biology — Posted on 2025-02-27
318 TEAD inhibition alters the lung immune microenvironment and attenuates metastasis.
Sharif, G. M.; Rahhal, R.; Schmidt, M. O.; Moussa, M.; Asemi, T.; Battina, R.; Kiliti, A.; Riegel, A. T.; Wellstein, A.
10.1101/2025.02.26.639326 — cancer biology — Posted on 2025-02-27
319 A breast tissue-specific epigenetic clock provides accurate chronological age predictions and reveals de-correlation of age and DNA methylation in tumor-adjacent and tumor samples
Garma, L. D.; Pernas, S.; Baz, D. V.; Garcia Campelo, R.; Terrasa, J.; Colomer, R.; Jimenez, D.; Vera Garcia, R.; Bermejo, B.; Gonzalez Santiago, S.; Quintela-Fandino, M.
10.1101/2025.02.21.639537 — cancer biology — Posted on 2025-02-27
321 CCRL2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated TP53
Naji, N. S.; Pasca, S.; Chatzilygeroudi, T.; Toledano-Sanz, P.; Rimando, J.; Hemani, Y.; Perkins, B.; Zeng, X.; Talbot, C.; Paun, B.; Abdulmalik, A.; Lossos, C.; Boronina, T. R.; Sinanidis, I.; Tsakiroglou, P.; Fernandes, P.; Esteb, C.; Ambinder, A. J.; Cole, R. N.; Xian, R.; Gojo, I.; Paul, S.; Levis, M. J.; DeZern, A. E.; Luznik, L.; Karanika, S.; Resar, L. S.; Jones, R. J.; Bunz, F.; Gondek, L.; Arvanitis, M.; Karantanos, T.
10.1101/2025.02.21.639304 — cancer biology — Posted on 2025-02-27
322 Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia
Hossen, M. A.; Jahan, U. M. S.; Hossain, M. A.; Asif, K. H.; Rahmana, A.; Ahmed, S.; Uddin, M. M.; Amin, M. F.; Barik, M. A.; Islam, M. J.; Kamruzzaman, M.; Hasnat, S.; Uddin, M. N.; Islam, T.; Hoque, M. N.
10.1101/2025.02.22.639676 — cancer biology — Posted on 2025-02-27
323 Cigarette Smoke and Decreased DNA Repair by Xeroderma Pigmentosum Group C Use a Double Hit Mechanism for Epithelial Cell Lung Carcinogenesis
Al Nasrallah, N.; Lee, B.; Wiese, B. M.; Karam, M. N.; Mickler, E. A.; Zhou, H.; Paolelli, N.; Stearman, R.; Geraci, M. W.; Sears, C. R.
10.1101/2025.02.22.639660 — cancer biology — Posted on 2025-02-27
326 CDK9 degradation Inhibits Gastroesophageal Cancer growth and Overcomes Radiation Resistance by Increasing Chromatin Accessibility and Downregulating YAP1/TEAD signaling
Zhang, Y.-t.; Ghelfi, M.; Xue, Y.; Chen, H.; Calendo, G.; Grana, G.; Li, Y.; Athavale, D.; Balch, C.; Yao, X.; Chung, W.; Wang, Z.; Spitz, F.; Tang, T.; Khazak, V.; Zhou, J.; Issa, J.-P.; Song, S.
10.1101/2025.02.22.639565 — cancer biology — Posted on 2025-02-27
330 Fast-tracking native mass spectrometry: Skipping over buffer exchange
Grun, A. F. R.; Said, F.-A.; Schamoni-Kast, K.; Damjanovic, T.; Bosse, J. B.; Uetrecht, C.
10.1101/2025.02.22.639503 — biophysics — Posted on 2025-02-27
331 Hydrodynamic Radius Determination of Tau and AT8 Phosphorylated Tau Mutants: A Combined Simulation and Experimental Study
Lohberger, C.; Marien, J.; Bridot, C.; Prevost, C.; Allegro, D.; Tatoni, M.; Landrieu, I.; Smett-nocca, C.; Sacquin-Mora, S.; Barbier, P.
10.1101/2025.02.22.639620 — biophysics — Posted on 2025-02-27
332 Orthosteric interactions with PIP2 activate TMEM16A channels
Xu, J.; Santa Cruz, A.; Chandrashekar, A.; Kawano, T.; Zaka, M.; Cui, M.; Logothetis, D. E.; Plant, L. D.
10.1101/2025.02.24.639951 — biophysics — Posted on 2025-02-27
333 A database for large-scale docking and experimental results
Hall, B. W.; Tummino, T. A.; Tang, K.; Irwin, J. J.; Shoichet, B. K.
10.1101/2025.02.25.639879 — biophysics — Posted on 2025-02-27
334 The keratin cortex stabilizes cells at high strains
Meyer, R.; Rölleke, U.; Schwarz, N.; Perez-Tirado, A.; Schepers, A. V.; Janshoff, A.; Köster, S.
10.1101/2025.02.24.639846 — biophysics — Posted on 2025-02-27
339 Helical foldamers as selective G-quadruplex ligands
Koenig, A.; Laffile, V.; Thore, S.; Mackereth, C. D.; Yatsunyk, L.; Ferrand, Y.; Largy, E.; Gabelica, V.
10.1101/2025.02.25.640101 — biophysics — Posted on 2025-02-27
342 Ca2+ increases cardiac muscle viscoelasticity independent of active force development
Baker, A. J.; Li, O. Y.; Jezek, F.; Simpson, P. C.; Chesler, N. C.; Beard, D. A.
10.1101/2025.02.26.640328 — biophysics — Posted on 2025-02-27
343 Nanometer condensate organization in live cells derived from partitioning measurements
Dollinger, C.; Potolitsyna, E.; Martin, A. G.; Anand, A.; Datar, G. K.; Schmit, J. D.; Riback, J. A.
10.1101/2025.02.26.640428 — biophysics — Posted on 2025-02-27
347 Structural and Conformational Impact of Deleterious Spike Protein Mutations in SARS-CoV-2 Omicron Lineages
Khalid, A.; Ahmed, K.; Kanji, A.; Munir, T.; Bukhari, A. R.; Hasan, Z.; Van Voorhis, W.; Iqbal, N. T.
10.1101/2025.02.25.639252 — bioinformatics — Posted on 2025-02-27
349 Housekeeping genes are enriched in rheumatoid arthritis-related genes
Lv, W.; Tang, H.; Feng, G.; Zhang, S.; Shang, Z.; Zhang, M.; Chen, R.; Cheng, X.; Meng, X.; Lv, H.; Zhang, R.
10.1101/2025.02.22.639692 — bioinformatics — Posted on 2025-02-27
354 Generative and integrative modeling for transcriptomics with formalin fixed paraffin embedded material
Mucaki, E. J.; Zhang, W.; Saha, A.; Trebinjac, S.; Nofech-Mozes, S.; Rakovitch, E.; Dumeaux, V.; Hallett, M. T.
10.1101/2025.02.21.639356 — bioinformatics — Posted on 2025-02-27
355 Local graph-motif features improve gene interaction network prediction
Leon, V. J.; Matelsky, J. K.; Ernlund, A.; Kitchell, L. M.; Rawls, K. D.; Bishop, C.; Reilly, E.
10.1101/2025.02.21.639582 — bioinformatics — Posted on 2025-02-27
358 Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice
Keck, C. H. C.; Schmidt, E. L.; Roth, R. H.; Floyd, B. M.; Tsai, A. P.; Garcia, H. B.; Cui, M.; Chen, X.; Wang, C.; Park, A.; Zhao, S.; Liao, P. A.; Casey, K. M.; Reineking, W.; Cai, S.; Zhang, L.-Y.; Yang, Q.; Yuan, L.; Baghdasaryan, A.; Lopez, E. R.; Cooper, L.; Cui, H.; Esquivel, D.; Brinson, K.; Chen, X.; Wyss-Coray, T.; Coleman, T. P.; Brongersma, M. L.; Bertozzi, C. R.; Wang, G. X.; DIng, J. B.; Hong, G.
10.1101/2025.02.20.639185 — bioengineering — Posted on 2025-02-27
359 Advancing Cardiac Graft Assessment Methods During Normothermic Machine Perfusion to Achieve Improved Transplantation Outcomes
Ajenu, E.; Lopera Higuita, M.; Bolger-Chen, M.; Olverson, G.; Nguyen, K.; Singh, G.; Romfh, P.; Vincent, D.; Rabi, S. A.; Osho, A. A.; Tessier, S. N.
10.1101/2025.02.20.639392 — bioengineering — Posted on 2025-02-27
361 Matrix tropism influences endometriotic cell attachment patterns
Theriault, H. S.; Kimmel, H. R. C.; Nunes, A. C.; Paxhia, A.; Hashim, S.; Clancy, K. B. H.; Underhill, G. H.; Harley, B. A. C.
10.1101/2025.02.22.639314 — bioengineering — Posted on 2025-02-27
363 Detection of inertial effects in capillary flows in open and closed channels
Berthier, J.; Tokihiro, J. C.; McManamen, A. M.; Caira, T.; Shin, A.; Lee, J. J.; Theberge, A. B.; Berthier, E.
10.1101/2025.02.24.639324 — bioengineering — Posted on 2025-02-27
365 Establishment of an efficient one-step enzymatic synthesis of cyclic-2,3-diphosphoglycerate
Stracke, C.; Meyer, B. H.; DeRose, S. A.; Ferrandi, E. E.; Kublanov, I.; Isupov, M. N.; Harmer, N.; Monti, D.; Littlechild, J.; Mueller, F.; Snoep, J. L.; Braesen, C.; Siebers, B.
10.1101/2025.02.21.639460 — bioengineering — Posted on 2025-02-27
369 Structural implications of glycosylation on the voltage-gated sodium channel β3-subunit
Beaudoin, C. A.; Hayes, J.; Liu, H.; Namadurai, S.; Deery, M. J.; August, E. A.; Krasner, S.; Hamaia, S. W.; Salvage, S. C.; Huang, C. L.- H.; Jackson, A. P.
10.1101/2025.02.27.640513 — biochemistry — Posted on 2025-02-27
370 Development of a Genetically Encoded Live-Cell Iron Mapping System
Akyol, A.; Cimen, S.; Gottschalk, B.; Alston, A. B.; Digigow, R.; Flüehmann, B.; Eroglu, E.; Graier, W. F.; Malli, R.
10.1101/2025.02.25.639876 — biochemistry — Posted on 2025-02-27
373 Caging-group-free photoactivatable fluorophores with far-red emission
Lincoln, R.; Butkevich, A. N.; Gürth, C.-M.; Fischer, A.; Emmerich, A. R.; Fidlin, M.; Bossi, M. L.; Hell, S. W.
10.1101/2025.02.24.639818 — biochemistry — Posted on 2025-02-27
374 Structural basis for anomalous cellular trafficking behavior of glaucoma-associated A427T mutant myocilin
Hill, K. R.; Scelsi, H. F.; Youngblood, H. A.; Farali, J. A.; Itakura, T.; Fini, M. E.; Peters, D. M.; Lieberman, R. L.
10.1101/2025.02.26.640437 — biochemistry — Posted on 2025-02-27
376 Expanding the Tubulin Code: TTLL11 Polyglutamylase Drives Elongation of Primary Tubulin Chains
Campbell, J.; Vosahlikova, M.; Ismail, S.; Volnikova, M.; Motlova, L.; Kudlacova, J.; Ustinova, K.; Snajdr, I.; Novakova, Z.; Basta, M.; Gutsche, I.; Desfosses, A.; Barinka, C.
10.1101/2025.02.24.639257 — biochemistry — Posted on 2025-02-27
378 Retroelement co-option disrupts the cancer transcriptional programme
Loong, J.; Thompson, R.; Hall, C.; Doglio, L.; Pape, J.; Kassiotis, G.
10.1101/2025.02.21.639580 — genomics — Posted on 2025-02-27
379 Enrichment of helminth mitochondrial genomes from faecal samples using hybridisation capture
Papaiakovou, M.; Waeschenbach, A.; Anderson, R. M.; Cools, P.; Mekonnen, Z.; Littlewood, D. T. J.; Cantacessi, C.; Doyle, S. R.
10.1101/2025.02.24.639427 — genomics — Posted on 2025-02-27
381 Genetics in the ocean's twilight zone: Population structure of the Mueller's pearlside across its distribution range
Quintela, M.; Mateos-Rivera, A.; Lille-Langoy, R.; Besnier, F.; Tsagarakis, K.; Rodriguez-Ezpeleta, N.; Bao, M.; Wiech, M.; Giulietti, L.; Rabade-Uberos, S.; Saborido-Rey, F.; Chlaida, M.; Strand, E.; Knutar, S.; Garcia-Seoane, E.; Melle, W.; Axelsen, B. E.; Glover, K. A.
10.1101/2025.02.22.639266 — genetics — Posted on 2025-02-27
383 A Theory of Heterosis
Zeng, Z.-B.; Gesteira, G. D. S.; Mo, L.; Xiao, Y.; Yan, J.
10.1101/2025.02.24.639169 — genetics — Posted on 2025-02-27
386 Multi-platform evaluation and optimization of single-cell RNA isoform sequencing
Webber, J. T.; Bartlett, D. A.; Al-Eryani, G.; Khorgade, A.; Shin, A.; Georgescu, C.; Yu, H.; Haas, B. J.; Popic, V.; Al'Khafaji, A. M.
10.1101/2025.02.22.639662 — genetics — Posted on 2025-02-27
387 Influenza virus evolution and defective genome formation are shaped by host genotype and sex
Costa, R. M.; Alvarez-Acosta, L.; Curtis, K.; Kelleher, J.; Lamichhane, B. S.; Valesano, A. L.; Fitzsimmons, W. J.; Lauring, A. S.; Seger, J.; Adler, F. R.; Potts, W. K.
10.1101/2025.02.26.638946 — evolutionary biology — Posted on 2025-02-27
388 Insights into the Evolution of Ancient Shark and Ray Sex Chromosomes
Lee, S.-H.; Fedrigo, O.; Soler-Clavel, L.; Humble, E.; Lesturgie, P.; Balacco, J.; O'Toole, B.; Mountcastle, J.; Haase, B.; Brajuka, N.; Jain, N.; Tracey, A.; Absolon, D. E.; Pelan, S.; Pointon, D.-L.; Wood, J. M. D.; Rhie, A.; Macqueen, D. J.; Howe, K.; Jarvis, E.; Naylor, G. J. P.
10.1101/2025.02.26.637739 — evolutionary biology — Posted on 2025-02-27
389 Contact networks of small mammals highlight potential transmission foci of Lassa mammarenavirus.
Simons, D.; Goyal, R.; Bangura, U.; Gibb, R.; Rushton, B.; Sondufu, D.; Lamin, J.; Koninga, J.; Jimmy, M.; Dawson, M.; Lahai, J.; Ansumana, R.; Fichet-Calvet, E.; Watson-Jones, D.; Kock, R.; Jones, K. E.
10.1101/2025.02.25.639449 — ecology — Posted on 2025-02-27
391 A myofilament lattice model of Drosophila flight muscle sarcomeres based on multiscale morphometric analysis during development
Görög, P.; Tibor, N.; Polgar, T. F.; Biro, P.; Gutheil, A.; Kozma, C.; Gajdos, T.; Toth, K.; Alexandra, T. V.; Erdelyi, M.; Jozsef, M.; Szikora, S.
10.1101/2025.02.27.640547 — developmental biology — Posted on 2025-02-27
394 TEMI: Tissue Expansion Mass Spectrometry Imaging
Zhang, H.; Ding, L.; Hu, A.; Shi, X.; Huang, P.; Lu, H.; Tillberg, P. W.; Wang, M. C.; Li, L.
10.1101/2025.02.22.639343 — molecular biology — Posted on 2025-02-27
398 Drug repurposing reveals Posaconazole as a CYP11A1 inhibitor enhancing anti-tumour immunity
Pramanik, J.; Shaji, S. K.; Zaman, M.; Brown, B.; Zhang, B.; Yamashita-Kanemaru, Y.; Homer, N. Z. M.; Hussein, H.; Zhao, Q.; Okkenhaug, K.; Roychoudhuri, R.; Mukhopadhyay, A.; Mahata, B.
10.1101/2025.02.21.639414 — immunology — Posted on 2025-02-27
399 DNA origami vaccines program antigen-focused germinal centers
Romanov, A.; Knappe, G. A.; Ronsard, L.; Suh, H.; Omer, M.; Chapman, A. P.; Lewis, V.; Spivakovsky, K.; Canales, J.; Reizis, B.; Tingle, R.; Cottrell, C.; Schiffner, T.; Lingwood, D.; Bathe, M.; Irvine, D. J.
10.1101/2025.02.21.639354 — immunology — Posted on 2025-02-27
400 HIV-Induced Sialoglycans on Infected Cells Promote Immune Evasion from Myeloid Cell-Mediated Killing
Singh, S.; Islam, S. M. S.; Liu, R.; Adeniji, O. S.; Giron, L. B.; Saini, P.; Danesh, A.; Denton, P. W.; Jones, B.; Xiao, H.; Abdel-Mohsen, M.
10.1101/2025.02.21.639489 — immunology — Posted on 2025-02-27
402 Comprehensive analysis of myeloid reporter mice
Wang, Y.; Dowling, S. D.; Rodriguez, V.; Maciuch, J.; Mayer, M.; Therron, T. A.; Shaw, T. N.; Gurra, M. G.; Shah, C. L.; Makinde, H.-K. M.; Ginhoux, F.; Voehringer, D.; Harrington, C. A.; Lawrence, T.; Grainger, J. R.; Cuda, C. M.; Winter, D. R.; Perlman, H. R.
10.1101/2025.02.24.639159 — immunology — Posted on 2025-02-27
403 Monocyte control of organismal energy homeostasis
Martins, R.; Blankenhaus, B.; Braza, F.; Ventura, P.; Singh, S.; Weis, S.; Mesquita, M.; Pires, M.; Pagnotta, S.; Wu, Q.; Cardoso, S.; Jentho, E.; Figueiredo, A.; Faisca, P.; Novoa, A.; Morais, V.; Wculek, S.; Sancho, D.; Mallo, M.; Soares, M. P.
10.1101/2025.02.20.639373 — immunology — Posted on 2025-02-27
404 Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model
Rowlands, B. D.; Trist, B. G.; Karozis, C.; Schaffer, G.; Mor, D.; Harwood, R.; Rosolen, S. A.; Cottam, V.; Persson-Carboni, F.; Richardson, M.; Li, A. A.; Gotsbacher, M. P.; Abdeen, A. H.; Codd, R.; Double, K. L.
10.1101/2025.02.26.640461 — neuroscience — Posted on 2025-02-27
405 Mapping Hand Function with Simultaneous Brain-Spinal Cord Functional MRI
Oliva, V.; Bedard, S.; Kaptan, M.; Pfyffer, D.; Chy, B.; Aufrichtig, S.; Berhe, N.; Chaudhari, A. S.; Tharin, S.; Hu, S. S.; Ratliff, J.; Smith, Z. A.; Smith, A. C.; Glover, G. H.; Mackey, S.; Law, C. S. W.; Weber, K. A.
10.1101/2025.02.27.640504 — neuroscience — Posted on 2025-02-27
407 Growth hormone is required for hippocampal engram cell maturation
Kim, C.-H.; Park, H.; Han, D. H.; Hong, I.; Kim, Y.; Yu, N.-K.; Cho, J.; Kaang, B.-K.
10.1101/2025.02.27.640537 — neuroscience — Posted on 2025-02-27
408 Microelectrode array scaled for recording human hippocampal slices
Pelkonen, A.; Lezhneva, V.; Ryynanen, T.; Kreutzer, J.; Sitnikova, V.; Gomez-Budia, M.; Della Pietra, A.; Dougalis, A.; Kyyriainen, J.; Torkamani-Azar, M.; Eronen, H.; Rauramaa, T.; Immonen, A.; Leinonen, V.; Sierra, A.; Kalviainen, R.; Malm, T.
10.1101/2025.02.27.640534 — neuroscience — Posted on 2025-02-27
411 Decoding the neural basis of sensory phenotypes in Autism
Kolisnyk, M.; Lyons, K. M.; Choi, E. J.; Vandewouw, M.; Stojanoski, B.; Anagnostou, E.; Kushki, A.; Nicolson, R.; Kelley, E.; Georgiades, S.; Lerch, J.; Crosbie, J.; Schachar, R. J.; Ayub, M.; Jones, J.; Arnold, P.; Liu, X.; Stevenson, R.
10.1101/2025.02.27.640592 — neuroscience — Posted on 2025-02-27
412 INFLUENCE OF LIFESTYLE ON BRAIN SENSITIVITY TO CIRCULATING INSULIN-LIKE GROWTH FACTOR 1
Zegarra-Valdivia, J. A.; Khan, M. Z.; Putzolu, A.; Cipriani, R.; Pignatelli, J.; Torres Aleman, I.
10.1101/2025.02.27.640579 — neuroscience — Posted on 2025-02-27
413 Physical Network Constraints Define the Lognormal Architecture of the Brain's Connectome
Piazza, B.; Barabasi, D. L.; Ferreira Castro, A.; Menichetti, G.; Barabasi, A.-L.
10.1101/2025.02.27.640551 — neuroscience — Posted on 2025-02-27
414 Cortical Excitability during Fixations Drives Frequency-Specific Neural Activity in Children and Adults
Marriott Haresign, I.; Charman, T.; Johnson, M. H.; Mason, L.; Bazelmans, T.; Begum-Ali, J.; Jones, E. J. H.; Wass, S. V.
10.1101/2025.02.27.639836 — animal behavior and cognition — Posted on 2025-02-27
415 Contrasting roles of different mismatch repair proteins in basal-like breast cancer
Tithi, T. I.; Mo, J.; Borcherding, N.; Jo, S.; Cho, E.; Cash, K. E.; Honda, M.; Wang, L.; Ahmed, K. K.; Shirlekar, K.; Chen, L.; Weigel, R.; Kates, H.; Gibson-Corley, K.; Spies, M.; kolb, R.; Zhang, W.
10.1101/2023.07.20.549745 — cancer biology — Posted on 2025-02-27
418 Unravelling the neurocognitive mechanisms underlying counterconditioning in humans
Wirz, L.; Houtekamer, M. C.; de Vos, J.; Dunsmoor, J. E.; Homberg, J.; Henckens, M. J. A. G.; Hermans, E.
10.1101/2024.07.29.605706 — neuroscience — Posted on 2025-02-27
419 Super-resolution microscopy of mitochondrial mRNAs
Stoldt, S.; Maass, F.; Weber, M.; Dennerlein, S.; Ilgen, P.; Gaertner, J.; Canfes, A.; Schweighofer, S. V.; Jans, D. C.; Rehling, P.; Jakobs, S.
10.1101/2025.01.23.634455 — cell biology — Posted on 2025-02-27
420 Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability
Wethington, D.; Ahmad, S.; Potempa, M.; Giuliani, G.; Aguilar, O. A.; Poudel, M.; Grassmann, S.; Stewart, W.; Adams, N. M.; Sun, J. C.; Lanier, L. L.; Das, J.
10.1101/2023.09.07.556760 — immunology — Posted on 2025-02-27
421 Astrocytic contribution to auditory hypersensitivity in a mouse model of fragile X syndrome
Bergdolt, L.; Anding, A.; Alshaqi, O.; Arbabi, Z.; Douchey, M.; Eldridge, E.; Hoffman, K.; Reid, A.; Sapkota, K.; Padmashri, R.; Monaghan, D.; Taraschenko, O.; Dunaevsky, A.
10.1101/2025.02.14.638346 — neuroscience — Posted on 2025-02-27
422 Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC
Rosen, H. T.; Li, K.; Li, E. L.; Currier, B.; Brittain, S. M.; Garcia, F. J.; Beard, D. C.; Haenni-Holzinger, S.; Dovala, D.; McKenna, J. M.; Schirle, M.; Maimone, T. J.; Nomura, D. K.
10.1101/2025.02.24.639755 — cancer biology — Posted on 2025-02-27
423 De Novo Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein Binders
Montaner, C.; Lucchi, R.; Escobar-Rosales, M.; Exposit, M.; Diaz-Perlas, C.; Baker, D.; Oller-Salvia, B.
10.1101/2025.02.25.639922 — biochemistry — Posted on 2025-02-27
428 Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques
Sangesland, M.; Li, N.; Tsybovsky, Y.; Rodgers, M. D.; Han, J.; Rodriguez, A. J.; Ferguson, J. A.; Henry, A. R.; Smith, S. C.; Roberts-Torres, J.; Gillespie, R. A.; Liu, C.; Merriam, J.; Stephens, T.; Williams, C.; Maestle, E.; Corcoran, M.; Ravichandran, M.; Creanga, A.; Andrews, S. F.; Pierson, T. C.; Karlsson Hedestam, G. B.; Schramm, C. A.; Reed, D. S.; Douek, D. C.; Zhou, T.; Ward, A. B.; Kanekiyo, M.
10.1101/2025.02.21.639368 — immunology — Posted on 2025-02-27
429 The replication principle revisited: a shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates
Basile, G. A.; Ielo, A.; Bonanno, L.; Cerasa, A.; Santoro, G.; Milardi, D.; Anastasi, G. P.; Torre, A.; Baldari, S.; Laudicella, R.; Gaeta, M.; Quartu, M.; Serra, M. P.; Trucas, M.; Quartarone, A.; Saranathan, M.; Cacciola, A.
10.1101/2024.07.11.603063 — neuroscience — Posted on 2025-02-27
430 Uncertainty mapping and probabilistic tractography using Simulation-Based Inference in diffusion MRI: A comparison with classical Bayes
Manzano-Patron, J. P.; Deistler, M.; Schröder, C.; Kypraios, T.; Goncalves, P. J.; Macke, J. H.; Sotiropoulos, S. S. N.
10.1101/2024.11.19.624267 — neuroscience — Posted on 2025-02-27
432 Computational metabolomics reveals overlooked chemodiversity of alkaloid scaffolds in Piper fimbriulatum
Damiani, T.; Smith, J.; Hebra, T.; Perkovic, M.; Cicak, M.; Kadlecova, A.; Rybka, V.; Dracinsky, M.; Pluskal, T.
10.1101/2024.12.10.627739 — plant biology — Posted on 2025-02-27
434 Predicting tumour evolution and drug resistance from heterogenous longitudinal cancer data
Santacatterina, G.; Bergamin, R.; Zucchetto, A.; Laureana, R.; Del Principe, M. I.; Gattei, V.; Egidi, L.; Caravagna, G.
10.1101/2024.12.30.630757 — cancer biology — Posted on 2025-02-27
435 Investigation of the heterogeneity of cancer cells using single cell calcium profiling.
Bura, A.; Caussette, C.; Gueguinou, M.; Bellanger, D.; Robert, A.; Cancel, M.; Lacouette-Rata, M.; Fromont-Hankard, G.; Vandier, C.; Maheo, K.; Brouard, T.; Crottes, D.
10.1101/2024.01.14.575608 — cancer biology — Posted on 2025-02-27
438 Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice
Xu, K.; Corona-Avila, I.; Frutos, M. D.; Nunez-Sanchez, M. A.; Makhanasa, D.; Shah, P. V.; Guzman, G.; Ramos-Molina, B.; Priyadarshini, M.; Khan, M. W.
10.1101/2024.11.26.625530 — biochemistry — Posted on 2025-02-27
441 The cold-inducible RNA-binding protein RBM3 stabilises viral mRNA at the cooler temperatures of the upper respiratory tract.
Coutts, H. L.; Turkington, H. L.; Bonazza, S.; Getty, E. M. P. E.; Sukumar, S.; Power, U. F.; Courtney, D. G.
10.1101/2024.07.25.605104 — microbiology — Posted on 2025-02-27
444 Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition
Johnson, K. A.; Jones, F. K.; Ghadiali, R. S.; Luke, T.-H. A.; Sweeney, M. D.; Moffitt, R. A.; Mamchaoui, K.; Ricci, E.; Young, I.; Pisconti, A.
10.1101/2025.02.26.640472 — cell biology — Posted on 2025-02-27
445 Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation
Gierisch, M. E.; Barchi, E.; Marogna, M.; Wallnoefer, M. H.; Ankarcrona, M.; Naia, L.; Salomons, F.; Dantuma, N. P.
10.1101/2025.02.27.640505 — cell biology — Posted on 2025-02-27
451 Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release
Zarifi, N.; Asthana, P.; Doustmohammadi, H.; Klaus, C.; Sanchez, J.; Hunt, S. E.; Rakotoharisoa, R. V.; Osuna, S.; Fraser, J. S.; Chica, R. A.
10.1101/2025.02.21.639315 — biochemistry — Posted on 2025-02-27
452 Cryptochrome 4b protein is likely irrelevant for the radical pair based magnetoreception in the European robin
Xu, J.; Ameerjan, A. B. P.; Hungerland, J.; Langebrake, G.; Ravnsborg, T.; Jensen, O. N.; Schmidt, J.; Bartoelke, R.; Kasahara, T.; Satish, B.; Schwigon, L.; Dedek, K.; Nolte, A.; Liedvogel, M.; Solov'yov, I. A.; Mouritsen, H.
10.1101/2025.02.21.639466 — biochemistry — Posted on 2025-02-27
454 Formation of Condition-Dependent Alpha-Synuclein Fibril Strain in Artificial Cerebrospinal Fluid
Snieckute, R.; Sulskis, D.; Jocyte, A.; Venclovaite, U.; Tamulyte, R.; Ziaunys, M.; Smirnovas, V.; Sakalauskas, A.
10.1101/2025.02.21.639308 — biochemistry — Posted on 2025-02-27
455 Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Kim, M.; Kim, K.; Lee, J.; Barny, L. A.; Skaggs, L.; Romaine, I.; Jeon, K.; Codreanu, S. G.; Sherrod, S. D.; McLean, J. A.; Naren, A.; Sulikowski, G. A.; Plate, L.
10.1101/2025.02.22.639665 — biochemistry — Posted on 2025-02-27
457 Using time-series remote sensing to identify and track individual bird nests at large scales
Ernest, S. M.; Garner, L.; Weinstein, B.; Frederick, P.; Senyondo, H.; Yenni, G. M.; White, E. P.
10.1101/2025.02.21.639546 — ecology — Posted on 2025-02-27
458 Human Lung Alveolar Model with an Autologous Innate and Adaptive Immune Compartment
Cabon, L.; Steinacher, L.; Gjeta, B.; Pimentel Mendes, M.; Cremasco, F.; Cubela, I.; Bellavista, M.; Gaspa Toneu, L.; Lauer, L.; Yu, Q.; Okuda, R.; Nabet, B. Y.; Gayevskiy, V.; Siegel, M.; Ducret, A.; Lassalle, E.; Lazzaroni, G.; Nikoloff, J.; Camacho Rufino, M.; Zundel, C.; Kunz, L.; Zimmermann, T.; Stoll, B.; Roth, C.; Roth, A. B.; Mohindra, R.; Stokar-Regenscheit, N.; Gjorevski, N.; Braun, A.; Recaldin, T.; Camp, G.
10.1101/2025.02.27.640440 — cell biology — Posted on 2025-02-27
460 RIPK3-dependent sequential recruitment of MLKL and RIPK1 drives PANoptotic cell death and chemokine production
YANG, Y.; WANG, Y.; WANG, Y.; WU, E.; CHEN, H.; SUN, L.; ZHANG, C.; CAO, S.; LI, J.; QIANG, H.; ZHANG, L.; LOU, Y.; ZHOU, S.; ZHOU, Y.; ZHONG, R.; ZHONG, H.
10.1101/2025.02.26.640344 — cell biology — Posted on 2025-02-27
461 Mid-aged mice rapidly normalize dysglycemia but aggravate obesity-induced hypothalamic and microglial changes upon dietary obesity reversal
Zemer, A.; Haim, Y.; Tsitrina, A.; Chalifa-Caspi, V.; Muallem, H.; Pincu, Y.; Yoel, U.; Monsonego, A.; Rudich, A.
10.1101/2025.02.26.640035 — cell biology — Posted on 2025-02-27
465 Identification of astrocytomas through serum protein fingerprint using MALDI-TOF MS and machine learning
Lazari, L. C.; Silva, J. M.; Donado, P. R. S.; Shinjo, S. M. O.; Fernandes, L. R.; Ieva, A. D.; Palmisano, G.; Marie, S. K. N.
10.1101/2025.02.21.639567 — systems biology — Posted on 2025-02-27
467 Improving allometric models to estimate the proboscis length of tropical bees
Frühholz, K.; Kuba, K.; Pitz, M.; Windl, J.; Keller, A.; Brehm, G.; Rasmussen, C.; Leonhardt, S. D.; Mendes Diniz, U.
10.1101/2025.02.21.639535 — zoology — Posted on 2025-02-27
471 Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan
Preethy, S.; Sakamoto, S.; Higuchi, T.; Ichiyama, K.; Yamamoto, N.; Ikewaki, N.; Iwasaki, M.; Dedeepiya, V. D.; Srinivasan, S.; Rajmohan, M.; Senthilkumar, R.; Abraham, S. J.
10.1101/2023.06.06.543858 — genetics — Posted on 2025-02-27
473 Changes in the health-related ecosystem services and disservices provided by urban trees over multiple decades in a small city
Kwong, R.; Victor, T. E.; Dijstelbloem, N.; Dong, Z. Y.; Robillard, A. M.; Gagnon, W. A.; Simon, C. S.; Radhakrishnan, C. I.; Peralta, K. A.; Youngstrom, E. C.; Terjesen, E. C.; Tsignadze, M.; Okuyama, D.; Ma, M.; Katz, D. S. W.
10.1101/2025.02.21.639397 — ecology — Posted on 2025-02-27
474 The economic strategies of superorganisms
Leahy, L.; Riskas, H. L.; Halliwell, B.; Wright, I. J.; Carlesso, A. G.; Sanders, N. J.; Bishop, T. R.; Parr, C. L.; Chown, S. L.; Andersen, A. N.; Gibb, H.
10.1101/2025.02.21.639603 — ecology — Posted on 2025-02-27
477 Reference Library for Suspect Non-targeted Screening of Environmental Toxicants Using Ion Mobility Spectrometry-Mass Spectrometry
Teri, D.; Aly, N. A.; Dodds, J. N.; Zhang, J.; Thiessen, P. A.; Bolton, E. E.; Joseph, K. M.; Williams, A. J.; Schymanski, E. L.; Rusyn, I.; Baker, E. S.
10.1101/2025.02.22.639656 — ecology — Posted on 2025-02-27
480 Habitat complexity reduces feeding strength of freshwater predators
Aranbarri, M.; Flores, L.; de Guzman, I.; Larranaga, A.; Elosegi, A.; Rall, B. C.; Reiss, J.
10.1101/2025.02.22.639633 — ecology — Posted on 2025-02-27
481 Lonely plants in arid land are functionally hyperdiverse
Liancourt, P.; Martin, R.; Le Bagousse-Pinguet, Y.; Maestre, F. T.; Berdugo, M.; Delgado-Baquerizo, M.; Eldridge, D. J.; Saiz, H.; Soliveres, S.; Valencia, E.; GROSS, N.
10.1101/2025.02.21.639323 — ecology — Posted on 2025-02-27
482 Geographical variation in mitogenomes of the largetooth sawfish Pristis pristis: challenges and perspectives for conservation efforts
Rodrigues, A. E. S.; Brito, R. M. S.; Charvet, P.; Faria, V.; Cabanillas-Torpoco, M.; Aleixo, A.; Burlamaqui, T. C.; Luis, L. F. d. S. R. F.; Asenjo, A.; Siccha-Ramirez, R.; Nunes, J. L. S.; de Boer, H. J.; Cerca, J.; MAUVISSEAU, Q.; Ready, J. S.; de Luna, J. B.
10.1101/2025.02.22.639618 — ecology — Posted on 2025-02-27
483 Warmer climate threatens the occurrence of giant trees in the Amazon basin
de Lima, R. B.; de Oliveira, C. P.; Silva da Silva, D. A.; de Souza, D. G.; Goncalves, L.; Vasconcelos, C. d. C.; Batista, A. P. B.; de Matos Filho, J. R.; da Silva, J. P. G.; Lopes, I. J. C.; de Abreu, J. C.; Aparicio, P. d. S.; de Sousa, C. S. C.; Ometto, J. P.; Gorgens, E. B.
10.1101/2025.02.22.639664 — ecology — Posted on 2025-02-27
484 Listen, who is it? A novel method for studying the nightly and annual phenologies of cave bat communities in data deficient areas of the world.
Labadie, M.; Morand, S.; Caron, A.; De Nys, H. M.; Niama, F. R.; Nguilili, F.; TOBI, N.-; Bourgarel, M.; Bas, Y.; Roemer, C.
10.1101/2025.02.22.639615 — ecology — Posted on 2025-02-27
486 Human pluripotent stem cell-derived intestinal epithelial cells maintain small intestine-specific functions over time, even with repeated cell division
Chen, J.; Kuramochi, S.; Horiuchi, S.; Kawasaki, T.; Kakizaki, H.; Tabata, L.; Kimura, T.; Nakamura, K.; Akutsu, H.; Ishida, S.; Kikuchi, A.; Umezawa, A.
10.1101/2025.02.17.638577 — cell biology — Posted on 2025-02-27
487 Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control
Mesquita, F. S.; Abrami, L.; Forey, R.; Kunz, B.; Raclot,, C.; Bracq, L.; Martins, F.; Milovanovic, D.; Planet, E.; rosspopoff, O.; Trono, D.; van der Goot, F. G.
10.1101/2025.02.25.640160 — cell biology — Posted on 2025-02-27
488 Sphingolipid metabolism drives mitochondria remodeling during aging and oxidative stress
Ebert, A. C.; Hepowit, N. L.; Martinez, T. A.; Vollmer, H.; Singkhek, H. L.; Frazier, K. D.; Kantejeva, S. A.; Patel, M. R.; MacGurn, J. A.
10.1101/2025.02.26.640157 — cell biology — Posted on 2025-02-27
489 Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS)
Gradzka-Boberda, S.; Parui, I.; Chakraborty, P.; Anthony, D. P.; K. Puthussery, B.; Weber, A.; Brokatzky, D.; Giansanti, P.; Mergner, J.; Oellinger, R.; Rad, R.; Kirschnek, S.; Gentle, I. E.; Haecker, G.
10.1101/2025.02.25.640042 — cell biology — Posted on 2025-02-27
491 In vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitis
Yashaswini, C. N.; Cogliati, B.; Qin, T.; To, T.; Williamson, T.; Papp, T. E.; Li, K.; Rasul, R.; Chen, L.; Lightstone, A.; Aghajanian, H.; Parhiz, H.; Wang, S.; Rurik, J. G.; Epstein, J. A.; Friedman, S. L.
10.1101/2025.02.25.640143 — cell biology — Posted on 2025-02-27
494 Comparative Molecular, Innate, and Adaptive Impacts of Chemically Diverse STING Agonists
Mizuno, N.; Boehm, D.; Jimenez-Perez, K.; Abraham, J.; Springgay, L.; Rose, I.; DeFilippis, V.
10.1101/2025.02.21.639458 — immunology — Posted on 2025-02-27
496 Random Tree Model of Meaningful Memory
Zhong, W.; Can, T.; Georgiou, A.; Shnayderman, I.; Katkov, M.; Tsodyks, M.
10.1101/2024.12.11.627835 — neuroscience — Posted on 2025-02-27
497 Age-related changes in 'cortical' 1/f dynamics are linked to cardiac activity
Schmidt, F.; Danboeck, S. K.; Trinka, E.; Klein, D. P.; Demarchi, G.; Weisz, N.
10.1101/2022.11.07.515423 — neuroscience — Posted on 2025-02-27
498 Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation.
Murcott, B.; Honig, F.; Halliwell, D. O.; Tian, Y.; Robson, J. L.; Manasterski, P.; Pinnell, J.; Dix-Peek, T.; Uribe-Lewis, S.; Ibrahim, A. E.; Sero, J. E.; Gurovich, D.; Nikolaou, N. E.; Murrell, A.
10.1101/2025.02.21.639484 — cancer biology — Posted on 2025-02-27
499 STAT3 Sustains Tumorigenicity Following Mutant KRAS Ablation
D'Amico, S.; Kirillov, V.; Liu, J.; Qiu, Z.; Lei, X.; Qin, H.; Sheridan, B.; Reich, N. C.
10.1101/2025.02.21.639533 — cancer biology — Posted on 2025-02-27
500 Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Shinn, M. K.; Tomares, D. T.; Liu, V.; Pant, A.; Qiu, Y.; Song, Y. J.; Ayala, Y. M.; Strout, G. W.; Ruff, K. M.; Lew, M. D.; Prasanth, K. V.; Pappu, R. V.
10.1101/2025.02.26.640430 — biophysics — Posted on 2025-02-27
501 Compositional control of ageing kineticsin TDP-43 condensates
H Espejo, N.; Feito, A.; Sanchez-Burgos, I.; Garaizar, A.; M. Conde, M.; Rey, A.; Castro, A.; Collepardo-Guevara, R.; Tejedor, A. R.; R Espinosa, J.
10.1101/2025.02.21.639421 — biophysics — Posted on 2025-02-27
506 Hypoxia responses in arginase 2 deficient mice enhance cardiovascular health
XU, W.; Asosingh, K.; Janocha, A. J.; Madden, E.; Wanner, N.; Trotter, D.; Novotny, M. V.; Mulya, A.; Farha, S.; Erzurum, S. C.
10.1101/2025.02.20.639297 — physiology — Posted on 2025-02-26
507 The pivotal role of a novel free fatty acid receptor GPR164 in the intestinal barrier function
Ikeda, T.; Masujima, Y.; Watanabe, K.; Nishida, A.; Yamano, M.; Igarashi, M.; Sasaki, N.; Hironori, K.; Kimura, I.
10.1101/2025.02.20.639380 — physiology — Posted on 2025-02-26
510 Multiplexed in vivo base editing identifies functional gene-variant-context interactions
Acosta, J.; Johnson, G. A.; Gould, S. I.; Dong, K.; Lendner, Y.; Detres, D.; Atwa, O.; Bulkens, J.; Gruber, S.; Contreras, M. E.; Wuest, A. N.; Narendra, V. K.; Hemann, M.; Sanchez-Rivera, F. J.
10.1101/2025.02.23.639770 — cancer biology — Posted on 2025-02-26
513 Spatial self-organization of confined bacterial suspensions
Hokmabad, B. V.; Martinez-Calvo, A.; Gonzalez La Corte, S.; Datta, S. S.
10.1101/2025.02.20.639202 — biophysics — Posted on 2025-02-26
516 Reconstructed Cell-Type Specific Rhythms in Human Brain link Alzheimer's Pathology, Circadian Stress, and Ribosomal Disruption
Hollis, H. C.; Sharma, A.; Sheehan, P. W.; Maggi, L. B.; Weber, J. D.; Hammarlund, J. A.; Bennet, D. A.; Menon, V.; Musiek, E. S.; Anafi, R. C.
10.1101/2025.02.21.639499 — bioinformatics — Posted on 2025-02-26
517 Bivalent ligands as a new universal chemotype of BCL6 degrader by inducing aggregation
Hu, R.; Hu, X.-T.; Yang, Y.-Y.; Luo, P.; Li, C.-H.; Liu, Z.-H.; Yu, L.-T.; Wang, N.-Y.
10.1101/2025.02.25.638777 — biochemistry — Posted on 2025-02-26
518 Mapping Animal Cultures: The Animal Culture Database (ACDB)
Basava, K.; Alam, M. N. U.; Roberts, L.; Martinet, K.; Cherry, P.; Garcia-Verdugo, H.; Roman-Palacios, C.
10.1101/2025.02.26.640400 — animal behavior and cognition — Posted on 2025-02-26
519 Subgenome dominance of ALS target site mutations impacts herbicide resistance in allohexaploid Echinochloa crus-galli
Cutti, L.; Turra, G. M.; Machado, F. M.; Sulzbach, E.; Angonese, P. S.; Markus, C.; Gaines, T. A.; Merotto, A.
10.1101/2025.02.20.639371 — genetics — Posted on 2025-02-26
520 A monophyletic origin of domesticated barley
Tan, C.; Ye, L.; Chen, J.; Zhang, C.; Zhou, P.; Tong, C.; Chen, Z.; Waugh, R.; Li, C.; He, T.
10.1101/2025.02.26.638035 — evolutionary biology — Posted on 2025-02-26
521 Impaired autophagic flux in skeletal muscle of plectin-related epidermolysis bullosa simplex with muscular dystrophy
Zrelski, M. M.; Eckhardt, M.; Fichtinger, P.; Hoesele, S.; Sombke, A.; Mill, L.; Kustermann, M.; Schmidt, W. M.; Norwood, F.; Schloetzer-Schrehardt, U.; Wiche, G.; Schroeder, R.; Winter, L.
10.1101/2025.02.26.640276 — cell biology — Posted on 2025-02-26
522 Tarloxotinib targets tumor hypoxia to improve therapeutic efficacy of immune checkpoint inhibition in a TLR9 dependent manner
Fu, Z.; Jackson-Patel, V.; Farrand, K.; Guise, C.; Silva, S.; Dabb, A.; Lin, X.; Liu, E.; Ashoorzadeh, A.; Smaill, J. B.; Hermans, I. F.; Patterson, A. V.
10.1101/2025.02.24.635378 — immunology — Posted on 2025-02-26
523 Divergent granulopoiesis at extramedullary sites safeguards host defense
Roig, C. S.; Chevre, R.; Bender, A.; Vöcking, L. M.; Hageb, A.; Richter, M.; Farjia, M.; Braster, Q.; Guzman, M.; Sintes, J.; Sharma, S.; Lemnitzer, P.; Ahern, D.; Osei-Sarpong, C.; Engel, D.; Monaco, C.; Dersch, P.; Kilber, A.; Cerutti, A.; Chavakis, T.; Jablonska, J.; Soehnlein, O.
10.1101/2025.02.25.638781 — immunology — Posted on 2025-02-26
524 Disease tolerant mice shelter a pathogenic intestinal microbiota able to trigger lethal disease in low tolerant hosts
Vidal, V. M.; Ferreira, L. M.; Yilmaz, B.; Montes-Cobos, E. V.; Gama, A. M. S.; Kitoko, J. Z.; Rosa, S. G.; Teixeira, G. A.; Farias, J. N. D.; Raghavan, V.; Littman, D.; de Souza, H. S. P.; Canto, F. B.; Bozza, M. T.
10.1101/2025.02.20.639353 — immunology — Posted on 2025-02-26
525 Colonic inflammation modulates the intestinal circadian landscape
Butler, T.; Downton, P.; Dickson, S.; Martinez, A. L.; Simpkins, D.; Khoo, I.; Veal, S.; West, A.; Adamson, A. D.; Bechtold, D.; McLaughlin, J.; Gibbs, J. E.
10.1101/2025.02.20.639289 — immunology — Posted on 2025-02-26
526 Critical Period Plasticity is Associated withResilience to Short Unpredictable Stress
Williams, R.; van den Oord, C.; Lee, E.; Fedde, S.; Oscherwitz, G.; Ribic, A.
10.1101/2025.02.26.640466 — neuroscience — Posted on 2025-02-26
527 Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex
Dellal, S.; Zurita, H.; Valero, M.; Abad-Perez, P.; Kruglikov, I.; Meng, J. H.; Pronneke, A.; Hanson, J. L.; Mir, E.; Ongaro, M.; Wang, X.-J.; Buzsaki, G.; Machold, R. P.; Rudy, B.
10.1101/2025.02.26.640383 — neuroscience — Posted on 2025-02-26
528 Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analyses
Fjodorova, M.; Prapaiwongs, P.; Petter, O.; Morella, I.; Li, Z.; Hall, J.; Vinh, N.-N.; Davies, S.; Green, J.; Hall, J.; van den Bree, M.; Brambilla, R.; Li, M.
10.1101/2025.02.26.640425 — neuroscience — Posted on 2025-02-26
531 Activation of KCC2 during development alleviates cognitive, behavioral, and neural excitability in adult CDKL5-deficient mice
Arshad, M. N.; Bope, C.; Dengler, J. S.; Ng, S. F. J.; Smalley, J. L.; Nishi, T.; Zhong, Z.; Moss, S. J.; Davies, P. A.
10.1101/2025.02.26.640365 — neuroscience — Posted on 2025-02-26
533 Machine Learning-Based Drug Response Prediction Identifies Novel Therapeutic Candidates for Colorectal Cancer Cell Line KM-12
Chanchabi, C.; Paul, C.; Coulon, V.; Cicalini, I.; Pierogostino, D.; Vishwakarma, S.; Hernandez-Hernandez, S.; Hahne, M.; Ballester, P.
10.1101/2025.02.24.639035 — cancer biology — Posted on 2025-02-26
534 Mechanical strain modulates Min patterning and division in E. coli filaments
Nadal, M.; Guitou, L.; Diez, I.; Hurtado, J.; Martinez, A.; Grobas, I.; Buceta, J.
10.1101/2025.02.21.638242 — biophysics — Posted on 2025-02-26
537 Measurement of residual stress in the brain
Balouchzadeh, R.; Kroenke, C. D.; Garcia, K. E.; Bayly, P. V.
10.1101/2025.02.26.637925 — bioengineering — Posted on 2025-02-26
538 Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model
Steger, L.; Smit, C.; Robinson, K.; Leadingham, K. M. K.; Davidar, D.; Routkevitch, D.; Weber-Levine, C.; Jiang, K.; Quiroz, V.; Bauer, S.; Liang, R.; Suk, I.; Tyler, B.; Doloff, J. C.; Theodore, N.; Manbachi, A.
10.1101/2025.02.25.639133 — bioengineering — Posted on 2025-02-26
539 The graphene-based affinity cryo-EM grid for the endogenous protein structure determination
cho, U.-s.; An, S.; Ahn, E.; Koo, T.; Park, S.; Suh, B.; Rengasamy, K. P.; Lyu, G.; Kim, C.; Kim, B.; Kim, H.; Park, S.; Tan, D.
10.1101/2025.02.22.638683 — biochemistry — Posted on 2025-02-26
540 Basic-Leucine-Zipper Transcription Factors Regulate Selective Molecular Phenotypes in Regulatory T Cells During IL-2-Induced Activation
Tse, J.; Liu, X.; Eres, I.; Yamawaki, T.; Kanke, M.; Killian, M.; Amrute, J.; Chaudhry, A.; Sahoo, A.; Liu, W.-J.; Kao, C.-Y.; Luo, X.; Lu, J.; Lu, D.; Wang, S.; Martin, S.; Li, C.-M.
10.1101/2025.02.25.638325 — genomics — Posted on 2025-02-26
541 Diffeomorphic Independent Contrasts for Ancestral Reconstruction of Shapes
Severinsen, M. L.; Pedersen, M. A.; Nielsen, R.; Sommer, S.; Hipsley, C. A.
10.1101/2025.02.26.638985 — evolutionary biology — Posted on 2025-02-26
542 High genomic stability of wMel Wolbachia after introgression into three geographically distinct Aedes aegypti populations
Dainty, K. R.; Hawkey, J.; Supriyati, E.; Judd, L. M.; Uribe, A.; Velez, I. D.; Anh, D. D.; Arguni, E.; Tantowijoyo, W.; O'Neill, S.; Holt, K.; Simmons, C. P.; Flores, H. A.
10.1101/2025.02.24.638572 — evolutionary biology — Posted on 2025-02-26
544 Using aerial thermography to map terrestrial thermal environments in unprecedented detail
Alujevic, K.; Garcia-Costoya, G.; Ratia, N.; Schmitz, E.; Godkin, R.; Gopal, A.; Bujan, J.; Logan, M.
10.1101/2025.02.21.638895 — ecology — Posted on 2025-02-26
546 A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells
Brescia, M.; Chatrian, A.; Keselman, P.; Gallant, J.; Sorman Paulsson, E.; Mol, M. P. H.; Sjogren, R.; Raymond, K.; Orlova, V.; Barnes, K.; Wales, R.; Austerjost, J.; Olszowy, M. W.; Mummery, C. L.; van Meer, B. J.; Davis, R. P.
10.1101/2025.02.21.639078 — pharmacology and toxicology — Posted on 2025-02-26
547 Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid adaptive radiation
Blumer, L. M.; Burskaia, V.; Artiushin, I.; Saha, J.; Camacho Garcia, J.; Campuzano Jimenez, F.; Hooft Van Der Huysdynen, A.; Elkin, J.; Fischer, B.; Van Houtte, N.; Zhou, C.; Gresham, S.; Malinsky, M.; Linderoth, T.; Sawasawa, W.; Vernaz, G.; Bista, I.; Hickey, A.; Kucka, M.; Louzada, S.; Zatha, R.; Yang, F.; Rusuwa, B.; Santos, M. E.; Chan, Y. F.; Joyce, D. A.; Böhne, A.; Miska, E. A.; Ngochera, M.; Turner, G. F.; Durbin, R.; Svardal, H.
10.1101/2024.07.28.605452 — evolutionary biology — Posted on 2025-02-26
550 Hematopoietic stem cells undergo bidirectional fate transitions in vivo.
Fukushima, T.; Kristiansen, T. A.; Wong, L. P.; Keyes, S.; Tanaka, Y.; Mazzola, M.; Zhao, T.; He, L.; Yagi, M.; Hochedlinger, K.; Yamazaki, S.; Sadreyev, R. I.; Scadden, D. T.
10.1101/2025.02.23.639689 — cell biology — Posted on 2025-02-26
551 Dietary fibre controls blood pressure and cardiovascular risk by lowering large intestinal pH and activating the proton-sensing receptor GPR65
Xie, L.; Muralitharan, R. R.; Dinakis, E.; Antonacci, S.; Leung, K. C.; McArdle, Z.; Mirabito Colafella, K.; Nakai, M.; Paterson, M.; Peh, A.; Jama, H.; Salimova, E.; Anderson, D.; Ang, C.; Alam, M. J.; Yap, Y.-A.; Creek, D.; Robert, R.; Head, G.; O'Donnell, J.; Mackay, C. R.; Marques, F. Z.
10.1101/2022.11.17.516695 — molecular biology — Posted on 2025-02-26
552 Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Castranio, E. L.; Varghese, M.; Argyrousi, E. K.; Tripathi, K.; Soderbergh, L.; Bresnahan, E.; Lerner, D.; Garretti, F.; Zhang, H.; van de Loo, J.; Stimpson, C.; Talty, R.; Glabe, C.; Levy, E.; Wang, M.; Ivkov, M.; Zhang, B.; Lannfelt, L.; Guerin, B.; Lubell, W.; Rahimipour, S.; Dickstein, D. L.; Gandy, S. E.; Arancio, O.; Ehrlich, M. E.
10.1101/2025.02.25.639746 — neuroscience — Posted on 2025-02-26
554 KDM2B Silencing Elicits a Paracrine Mechanism Which Destabilizes SLUG, Promoting Differentiation of Basal-Like Breast Cancer Cells.
Fraile, E.-A.; Soysal, B.; Anastas, V.; Soysal, Z. T.; Serebrennikova, O.; Paraskevopoulou, M. D.; Chavdoula, E.; Tsichlis, P. N.
10.1101/2020.05.21.109819 — cancer biology — Posted on 2025-02-26
555 Data-driven fine-grained region discovery in the mouse brain with transformers
Lee, A. J.; Dubuc, A.; Kunst, M.; Yao, S.; Lusk, N.; Ng, L.; Zeng, H.; Tasic, B.; Abbasi-Asl, R.
10.1101/2024.05.05.592608 — bioinformatics — Posted on 2025-02-26
556 gRNAde: Geometric Deep Learning for 3D RNA inverse design
Joshi, C. K.; Jamasb, A. R.; Vinas, R.; Harris, C.; Mathis, S. V.; Morehead, A.; Anand, R.; Lio, P.
10.1101/2024.03.31.587283 — bioinformatics — Posted on 2025-02-26
559 Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences
Miedlar, E.; Hamilton, G. E.; Witus, S. R.; Gonske, S. J.; Riffle, M.; Zelter, A.; Klevit, R. E.; Asbury, C. L.; Dimitrova, Y. N.; Davis, T. N.
10.1101/2024.11.13.623448 — biochemistry — Posted on 2025-02-26
560 Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment
Wacholder, A.; Deutsch, E. W.; Kok, L. W.; van Dinter, J. T.; Lee, J.; Wright, J. C.; Leblanc, S.; Jayatissa, A. H.; Jiang, K.; Arefiev, I.; Cao, K.; Bourassa, F.; Trifiro, F.-A.; Bassani-Sternberg, M.; Baranov, P. V.; Bogaert, A.; Chothani, S.; Fierro-Monti, I.; Fijalkowska, D.; Gevaert, K.; Hubner, N.; Mudge, J. M.; Ruiz-Orera, J.; Schulz, J.; Vizcaino, J. A.; Prensner, J. R.; Brunet, M. A.; Martinez, T. F.; Slavoff, S. A.; Roucou, X.; Choudhary, J. S.; van Heesch, S.; Moritz, R. L.; Carvunis, A.-R.
10.1101/2025.02.19.639069 — genomics — Posted on 2025-02-26
561 Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C
Wang, X.; Xu, P.; Bentley-DeSousa, A.; Hancock-Cerutti, W.; Cai, S.; Johnson, B. T.; Tonelli, F.; Shao, L.; Talaia, G.; Alessi, D. R.; Ferguson, S. M.; De Camilli, P.
10.1101/2024.06.08.598070 — cell biology — Posted on 2025-02-26
564 Neural Prioritisation of Past Solutions Supports Generalisation
Hall-McMaster, S.; Tomov, M. S.; Gershman, S. J.; Schuck, N. W.
10.1101/2024.06.10.598294 — neuroscience — Posted on 2025-02-26
565 State-space trajectories and traveling waves following distraction
Batabyal, T.; Brincat, S. L.; Donoghue, J. A.; Lundqvist, M.; Mahnke, M. K.; Miller, E. K.
10.1101/2024.02.19.581020 — neuroscience — Posted on 2025-02-26
566 Generating functional plasmid origins with OriGen
Irvine, J.; Arora, J.; Martinson, J. N. V.; Patel, J. R.; Hasham, S. I.; Cress, B. F.; Rubin, B. E.
10.1101/2025.02.03.636306 — synthetic biology — Posted on 2025-02-26
573 Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection
Sui, L.; Zhao, Y.; Wang, H.; Chi, Y.; Xie, H.; Tian, T.; Wang, W.; Zhu, M.; Zhai, N.; Song, Z.; Xu, Y.; Zhang, K.; Che, L.; Wang, G.; Liu, N.; Zhao, Y.; Liu, Q.
10.1101/2025.02.26.640292 — microbiology — Posted on 2025-02-26
575 High-Throughput Conjugation Reveals Strain Specific Recombination Patterns Enabling Precise Trait Mapping in Escherichia coli
Corneloup, T.; BELLENGIER, J.; Magnan, M.; Chavan, A.; Gachet, B.; Dixit, Z.; Pintard, C.; Baron, A.; Toko, D.; Lambert, A.; Choudhury, A.; Tenaillon, O.
10.1101/2025.02.26.640286 — microbiology — Posted on 2025-02-26
576 TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral Yersinia infection
Peterson, S. T.; Dailey, K. G.; Hullahalli, K.; Sorobetea, D.; Matsuda, R.; Sewell, J.; Yost, W.; O'Neill, R.; Bobba, S.; Apenes, N.; Sherman, M. E.; Balazs, G. I.; Assenmacher, C.-A.; Cox, A.; Lanza, M.; Shin, S.; Waldor, M.; Brodsky, I. E.
10.1101/2025.02.26.639286 — microbiology — Posted on 2025-02-26
577 Macrogenetic atlas of prokaryotes
Yang, C.; Huang, H.; Wang, N.; Didelot, X.; Yang, R.; Cui, Y.; Falush, D.
10.1101/2025.02.26.640246 — microbiology — Posted on 2025-02-26
578 Risk-reward trade-off in motility endurance generates dichotomy in search strategies among copiotrophic marine bacteria
Keegstra, J. M.; Landry, Z.; Zweifel, S. T.; Roller, B. R. K.; Martinez-Perez, C.; Clerc, E. E.; Ackermann, M.; Stocker, R.
10.1101/2025.02.26.640445 — microbiology — Posted on 2025-02-26
580 Freshwater snail faecal metagenomes reveal environmental reservoirs of antimicrobial resistance genes across two continents
O'Ferrall, A. M.; Juhasz, A.; Jones, S.; Makaula, P.; Namacha, G.; Ame, S.; Oguttu, D.; Foo, A.; Kayuni, S. A.; LaCourse, J. E.; Musaya, J.; Stothard, R.; Roberts, A. P.
10.1101/2025.02.26.640299 — microbiology — Posted on 2025-02-26
581 A Machine Learning Approach Elucidates Spatial Patterns of Environmental Properties Driving Microbial Composition Over Santos Basin, South Atlantic
Moreira, J. C. F.; Modolon, F.; Bergo, N. M.; Vieira, D. C.; Fonseca, G.; Peres, F. V.; Lizarraga, R. G.; Duque-Castano, D. C.; Emilio, A. M.; Amendola, A. M.; Romano, R. G.; Chuqui, M. G.; Paula, F. S.; Moreira, D. L.; Jonck, C. R.; Bendia, A. G.; Brandini, F. P.; Pellizari, V. H.
10.1101/2025.02.26.640418 — microbiology — Posted on 2025-02-26
582 The female intimate microbiome space
Vander Donck, L.; Gehrmann, T.; Ahannach, S.; Van den Bosch, S.; Hiel, M.; Delanghe, L.; Allonsius, C. N.; Cauwenberghs, E.; Spacova, I.; Oerlemans, E.; Wittouck, S.; De Boeck, I.; Donders, G.; Verhoeven, V.; Lebeer, S.
10.1101/2025.02.26.640345 — microbiology — Posted on 2025-02-26
584 Sediments from a seasonally euxinic coastal ecosystem show high nitrogen cycling potential
Rigutto, I. M. L.; Sburlan, S. C.; de Bont, L. W. P.; Berben, T.; de Graaf, R. M.; Slomp, C. P.; Jetten, M. S. M.
10.1101/2025.02.26.640368 — microbiology — Posted on 2025-02-26
586 Eukaryotes' closest relatives are internally simple syntrophic archaea
Imachi, H.; Nobu, M. K.; Ishii, S.; Hirakata, Y.; Ikuta, T.; Isaji, Y.; Miyata, M.; Miyazaki, M.; Morono, Y.; Murata, K.; Nakagawa, S.; Ogawara, M.; Okada, S.; Saito, Y.; Sakai, S.; Shimamura, S.; Tahara, Y. O.; Takaki, Y.; Takano, Y.; Tasumi, E.; Uematsu, K.; Yoshimura, T.; Takai, K.
10.1101/2025.02.26.640444 — microbiology — Posted on 2025-02-26
588 Targeting tGLI1, a novel mediator of tumor therapeutic resistance, using Ketoconazole sensitizes glioblastoma to CDK4/6 therapy and Chemoradiation
Yu, Y.; Arrigo, A.; Chandra, A.; Zhuang, C.; Najjar, M. K.; Khan, M. S.; Zhu, D.; Dono, A.; Strowd, R. E.; Tandon, N.; Zhu, J.-J.; Hsu, S. H.; Esquenazi, Y.; Chan, M.; Lo, H.-W.
10.1101/2025.02.20.639359 — cancer biology — Posted on 2025-02-26
597 PP4Psy2 regulates Rrm3 and Pif1 helicases to facilitate DSB resection across tandem retrotransposons
Campos, A.; Pulido, L.; Iglesias, L.; Delgado, C.; Sanchez, M.; Villoria, M. T.; Clemente-Blanco, A.
10.1101/2025.02.19.639064 — molecular biology — Posted on 2025-02-26
598 Prebiotic xylo-oligosaccharides for alleviation of hepatic steatosis: Results from a four-month dietary intervention and determinants of response
Hintikka, J. E.; Permi, P.; Lehtonen, M.; Lensu, S.; Driuchina, A.; Jormanainen, M.; Laukkanen, J.; Bayal, N.; Erawijantari, P. P.; O'Connell, T. M.; Lahti, L.; Pekkala, S.
10.1101/2025.02.19.638992 — systems biology — Posted on 2025-02-26
599 Most ventral pallidal cholinergic neurons are cortically projecting bursting basal forebrain cholinergic neurons
Schlingloff, D.; Szabo, I.; Gulyas, E.; Kiraly, B.; Kispal, R.; Stephenson-Jones, M.; Hangya, B.
10.1101/2025.02.23.639747 — neuroscience — Posted on 2025-02-26
608 The vaginal microbiota composition influences cervicovaginal and systemic inflammation induced by Chlamydia trachomatis infection.
ADAPEN, C.; Reot, L.; Nunez, N.; Cannou, C.; Marlin, R.; Lemaitre, J.; Lakoum, S.; Diry, S.; D'Agata, L.; Gros, W.; Gallouët, A.-S.; Leonec, M.; Bossevot, L.; Dereuddre-Bosquet, N.; Le Grand, R.; Nugeyre, M.-T.; Menu, E.
10.1101/2025.02.20.638673 — immunology — Posted on 2025-02-26
609 Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia Syndrome
Lozano-Gil, J. M.; Rodriguez-Ruiz, L.; Palacios, M.; Peral, J.; Navarro, S.; Fuster, J. L.; Belendez, C.; Jerez, A.; Murillo-Sanjuan, L.; Diaz-de-Heredia, C.; Lopez-de-Ontanar, G.; Zubicaray, J.; Sevilla, J.; Ferrer-Marin, F.; Sepulcre, M. P.; Cayuela, M. L.; Garcia-Moreno, D.; Martinez-Lopez, A.; Tyrkalska, S. D.; Mulero, V.
10.1101/2025.02.20.639294 — immunology — Posted on 2025-02-26
610 Layer V Neocortical Neurons From Individuals With Drug-Resistant Epilepsy Show Multiple Synaptic Alterations but Lack Somatic Hyperexcitability
Marquez, L. A.; Martinez-Aguirre, C.; Gutierrez-Castaneda, E.; Griego, E.; Sollozo-Dupont, I.; Lopez-Preza, F.; Alonso-Vanegas, M.; Rocha Arrieta, L.; Galvan, E. J.
10.1101/2025.02.26.640307 — neuroscience — Posted on 2025-02-26
611 Reorganization of motor functions within visuomotor networks subsequent to somatosensory cortical damage
Liu, Y.; Halfen, E. J.; Yau, J.; Fischer-Baum, S.; Kohler, P.; Faseyitan, O.; Coslett, H. B.; Medina, J.
10.1101/2025.02.25.640230 — neuroscience — Posted on 2025-02-26
612 Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence
Hashikawa, K.; Hashikawa, Y.; Briones, B.; Ishii, K. K.; Liu, Y.; Rossi, M.; Basiri, M. L.; Chen, J. Y.; Ahmad, O.; Mukundan, R.; Johnston, N.; Simon, R.; Soetedjo, J.; Siputro, J.; McHenry, J.; Palmiter, R. D.; Rubinow, D.; Zweifel, L. S.; Stuber, G. D.
10.1101/2025.02.26.640339 — neuroscience — Posted on 2025-02-26
614 Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women
Dumont, L.; Richard, G.; Espagnet, R.; Frisch, F.; Fortin, M.; Samson, A.; Bouchard, J.; Fontaine, R.; Croteau, E.; Phoenix, S.; Dubreuil, S.; Guerin, B.; Turcotte, E. E.; Carpentier, A. C.; Blondin, D. P.
10.1101/2025.02.24.639578 — physiology — Posted on 2025-02-26
616 Structural Plasticity of RRE Stem-Loop II Modulates Nuclear Export of HIV-1 RNA
Ojha, M.; Hudson, L.; Photenhauer, A.; Zang, T.; Lerew, L.; Ekesan, S.; Daniels, J.; Nguyen, M.; Paudyal, H.; York, D. M.; Ohi, M. D.; Marchant, J.; Bieniasz, P. D.; Koirala, D.
10.1101/2025.02.20.639096 — biophysics — Posted on 2025-02-26
617 Combining MicroED and native mass spectrometry for structural discovery of enzyme-biosynthetic inhibitor complexes
Vlahakis, N. W.; Flowers, C. W.; Liu, M.; Agdanowski, M.; Johnson, S.; Summers, J. A.; Keyser, C.; Russell, P.; Rose, S.; Orlans, J.; Adhami, N.; Chen, Y.; Sawaya, M. R.; Basu, S.; De Sanctis, D.; Wakatsuki, S.; Nelson, H. M.; Loo, J.; Tang, Y.; Rodriguez, J. A.
10.1101/2025.02.20.638743 — biophysics — Posted on 2025-02-26
618 Bilayer-forming lipids enhance archaeal monolayer membrane stability
Saracco, M.; Schaeffer, P.; Tourte, M.; Albers, S.-V.; Louis, Y.; Peters, J.; Deme, B.; Fontanay, S.; Oger, P. M.
10.1101/2025.02.20.639260 — biophysics — Posted on 2025-02-26
619 Unveiling Candidate Drivers in Cancer Progression Using Somatic-IV Analysis
Zhang, W.; Gaffari, S.; Browne, A.; Macintosh, C.; Lu, X.; Dang, H.; Lopez, G.; Wang, K.
10.1101/2025.02.20.638369 — bioinformatics — Posted on 2025-02-26
620 Single-Cell Resolution of Cellular Damage Illuminates Disease Progression
Padvitski, T.; Unger Avila, P.; Chen, H.; Oezel, C.; Braun, F.; Mueller, R.-U.; Westermark, P.; Brinkkoetter, P.; Schermer, B.; Benzing, T.; Wunderlich, T.; Kann, M.; Beyer, A.
10.1101/2025.02.20.639269 — bioinformatics — Posted on 2025-02-26
622 pH-Responsive Near Infrared Light Triggered Hydroxyapatite Nanoparticles for Targeted Photothermal Cancer Therapy
Palanikumar, L.; Yasin, F. M.; Munkhjargal, I.; Boitet, M.; Ali, L.; Ali, M. S.; Straubinger, R.; Barrera, F. N.; Magzoub, M.
10.1101/2025.02.20.639217 — bioengineering — Posted on 2025-02-26
624 ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models
Kim, D.-S.; Funcke, J.-B.; Chen, S.; Min, K.; Onodera, T.; Kim, M.; Velasco, J.; Virostek, M.; Walendzik, K.; Scherer, P. E.
10.1101/2025.02.20.639288 — genetics — Posted on 2025-02-26
625 Resource economics of tree communities control soil food web multifunctionality in European forests
Henneron, L.; Wardle, D. A.; Berg, M. P.; Hattenschwiler, S.; Bauhus, J.; Buscot, F.; Coq, S.; Decaens, T.; Fromin, N.; Ganault, P.; Gillespie, L. M.; Goldmann, K.; Matula, R.; Milcu, A.; Muys, B.; Nahmani, J.; Prada-Salcedo, L. D.; Scherer-Lorenzen, M.; Verheyen, K.; Wambsganss, J.; Kardol, P.
10.1101/2025.02.19.639063 — ecology — Posted on 2025-02-26
627 A cell-type specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage
Matias, N. R.; Gallicchio, L.; Lu, D.; Kim, J. J.; Perez, J.; Detweiler, A.; Lu, C.; Bolival, B.; Fuller, M. T.
10.1101/2025.02.25.640250 — developmental biology — Posted on 2025-02-26
628 WITHDRAWN: SA55 broadly neutralizes SARS-CoV-2 and robustly prevents viral escape by JN.1 sublineages
Shi, L.; Bowen, A.; Han, J.; Zheng, X.; Luo, H.; Yao, T.; Guo, M.; Yu, Y.; Jian, F.; Cao, Y. R.; ke, l.; Guo, Y.; Liu, L.
10.1101/2025.02.12.638008 — microbiology — Posted on 2025-02-26
630 A Metabolite-Based Resistance Mechanism Against Malaria
Figueiredo, A.; Trikha Rastogi, S.; Ramos, S.; Nogueira, F.; De Villiers, K.; Goncalves de Sousa, A. G.; Votborg-Novel, L.; von Wedel, C.; Tober-Lau, P.; Jentho, E.; Pagnotta, S.; Mesquita, M.; Cardoso, S.; Bortolussi, G.; Muro, A. F.; Tranfield, E. M.; Thibaud, J.; Duarte, D.; Sousa, A. L.; Pinto, S. N.; Kitoko, J.; Mombo-Ngoma, G.; Mischlinger, J.; Junttila, S.; Alenquer, M.; Amorim, M. J.; Vasavda, C.; Bosma, P. J.; Violante, S.; Drotleff, B.; Paixao, T.; Portugal, S.; Kurth, F.; Elo, L. L.; Paul, B. D.; Martins, R.; Soares, M. P.
10.1101/2025.02.20.639306 — immunology — Posted on 2025-02-26
631 Extracellular matrix remodeling during aging aligns with synapse, microglia, and cognitive status
Gray, D. T.; Guitierrez, A.; Jami-Alahmadi, Y.; Pandey, V.; Pan, L.; Zhang, Y. T.; Wohlschlegel, J. A.; McDevitt, R.; De Biase, L. M.
10.1101/2024.01.04.574215 — neuroscience — Posted on 2025-02-26
632 Mature neutrophils promote long-term functional recovery after spinal cord injury in a sex-dependent manner
Pacheco, M. R.; Tran, A. V.; Bradley, M.; Leal-Garcia, M. E.; Ozturgut, M.; Chakka, V.; Devaraj, S.; Kirchhoff, M.; Mulamba, T.; Thomas, K.; Vu, N. V.; McCreedy, D.
10.1101/2025.02.25.640256 — neuroscience — Posted on 2025-02-26
637 Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reporters
Malka-Gibor, E.; Oliver, K. M.; Chen, S.; Garcia-Diaz, A.; Williams, D.; Corneo, B.; de Nooij, J. C.
10.1101/2025.02.25.640131 — neuroscience — Posted on 2025-02-26
641 Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Castranio, E. L.; Varghese, M.; Argyrousi, E. K.; Tripathi, K.; Soderbergh, L.; Bresnahan, E.; Lerner, D.; Garretti, F.; Zhang, H.; van de Loo, J.; Stimpson, C.; Talty, R.; Glabe, C.; Levy, E.; Wang, M.; Ivkov, M.; Zhang, B.; Lannfelt, L.; Guerin, B.; Lubell, W.; Rahimipour, S.; Dickstein, D. L.; Gandy, S. E.; Arancio, O.; Ehrlich, M. E.
10.1101/2025.02.25.639746 — neuroscience — Posted on 2025-02-26
642 Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health
Shafiei, G.; Esper, N. B.; Hoffmann, M. S.; Ai, L.; Chen, A. A.; Cluce, J.; Covitz, S.; Giavasis, S.; Lane, C.; Mehta, K.; Moore, T. M.; Salo, T.; Tapera, T. M.; Calkins, M. E.; Colcombe, S.; Davatzikos, C.; Gur, R. E.; Gur, R. C.; Pan, P. M.; Jackowski, A. P.; Rokem, A.; Rohde, L. A.; Shinohara, R. T.; Tottenham, N.; Zuo, X.-N.; Cieslak, M.; Franco, A. R.; Kiar, G.; Salum, G. A.; Milham, M. P.; Satterthwaite, T. D.
10.1101/2025.02.24.639850 — neuroscience — Posted on 2025-02-26
649 A journey towards developing a new cleavable crosslinker reagent for in-cell crosslinking
Mueller, F.; Brutiu, B. R.; Saridakis, I.; Leischner, T.; Birklbauer, M. J.; Matzinger, M.; Madalinski, M.; Lendl, T.; Shaaban, S.; Dorfer, V.; Maulide, N.; Mechtler, K.
10.1101/2024.11.05.621843 — biochemistry — Posted on 2025-02-26
653 The mechanism how Pretubulysin-induced microtubule disassembly improves T cell search efficiency
Montalvo, G.; Shaebani, R.; Nandakumar, S.; Cowley, N.; Zhao, R.; Hawkins, R.; Hoth, M.; Lauterbach, M. A.; Schaedel, L.; Qu, B.; Lautenschlaeger, F.
10.1101/2025.02.24.639827 — cell biology — Posted on 2025-02-26
654 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Yayeh, M.; Alemayehu, M. M.; Anagaw, B.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-02-26
656 Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency
Naqvi, A. S.; Corbett, R. J.; Seghal, P.; Conkrite, K. L.; Rathi, K. S.; Ennis, B. M.; Hayer, K. E.; Zhang, B.; Brown, M. A.; Miller, D. P.; Kraya, A.; Coleman, K. L.; Dybas, J. M.; Geng, Z.; Blackden, C.; Arif, S.; Chroni, A.; Lahiri, A.; Hollawell, M. L.; Storm, P. B.; Haydar, D.; Foster, J. B.; Koptyra, M.; Madsen, P. J.; Diskin, S. J.; Thomas-Tikhonenko, A.; Resnick, A. C.; Rokita, J. L.
10.1101/2024.08.03.606419 — genomics — Posted on 2025-02-26
657 Pharmacological Inhibition of SUMOylation with TAK-981 Mimics Genetic HypoSUMOylation in Murine Perigonadal White Adipose Tissue
Dufour, D.; Zhao, X.; Chaleil, F.; Nothnagel, P. M.; Bjoras, M.; Lefrancois-Martinez, A.-M.; Martinez, A.; Chymkowitch, P.
10.1101/2024.11.23.624974 — developmental biology — Posted on 2025-02-26
658 Dysregulation of the actin cytoskeleton and FMRP causes polar body protrusion defects in human fragile X premutation and aged oocytes
Gerhardt, J.; McCarter, K.; Deshpande, M.; Romanski, P.; Stratopoulou, C. A.; Zaninovic, N.; Tareen, M.; Al-Mousawi, R.; James, D.; Madireddy, A.; Rosenwaks, Z.
10.1101/2025.02.23.639319 — cell biology — Posted on 2025-02-26
661 Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System
Aspal, M.; Pushlar, N.; Melameka, M.; McVicar, R. N.; Smith, E.; Ogunyamoju, T.; Kumar, M.; Marth, J. D.; Chun, J.; Snyder, E. Y.; Leibel, S. L.
10.1101/2025.02.24.639173 — cell biology — Posted on 2025-02-26
662 Unveiling the Cellular and Molecular Mechanisms of Diabetic Retinopathy with Human Retinal Organoids
Polesovska, L.; Trmacova, S.; Celiker, C.; Hruba, E.; Gambin, F. M.; Matuskova, V.; Beli, E.; Barta, T.
10.1101/2025.02.24.639921 — cell biology — Posted on 2025-02-26
664 Localization of KANK2 to Focal or Fibrillar Adhesions Influences Migration in Melanoma Cell Lines
Stojanovic, N.; Rac Justament, A.; Loncaric, M.; Tadijan, A.; Paradzik, M.; Acman, M.; Humphries, J. D.; Humphries, M. J.; Ambriovic-Ristov, A.
10.1101/2025.02.24.639831 — cell biology — Posted on 2025-02-26
666 Dopamine D1 receptor expression in prefrontal parvalbumin neurons influences distractibility across species
Joyce, M. K. P.; Ivanov, T. G.; Krienen, F.; Mitchell, J.; Ma, S.; Inoue, W.; Nandy, A. P.; Datta, D.; Duque, A.; Arellano, J. I.; Gupta, R.; Gonzalez-Burgos, G.; Lewis, D. A.; Sestan, N.; McCarroll, S. A.; Martinez-Trujillo, J. C.; Froudist-Walsh, S.; Arnsten, A. F.
10.1101/2024.06.15.599163 — neuroscience — Posted on 2025-02-26
667 CroCoDeEL: accurate control-free detection of cross-sample contamination in metagenomic data
Goulet, L.; Onate, F. P.; Famechon, A.; Quinquis, B.; Belda, E.; Prifti, E.; Le Chatelier, E.; Gautreau, G.
10.1101/2025.01.15.633153 — bioinformatics — Posted on 2025-02-26
669 Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis
Moreno Borrallo, A.; Jaramillo Ortiz, S.; Schaeffer-Reiss, C.; Quintard, B.; Rey, B.; Bize, P.; Viblanc, V. A.; Boulinier, T.; Chastel, O.; S. Gutierrez, J.; Masero, J. A.; Bertile, F.; Criscuolo, F.
10.1101/2024.07.02.600014 — evolutionary biology — Posted on 2025-02-26
671 WITHDRAWN: Purifying Selection and Persistent Polymorphism among Nuclei in the Multinucleate Arbuscular Mycorrhizal (AM) Fungi
Manyara, D.; Sanchez-Garcia, M.; Thoren, M. H.; Montoliu-Nerin, M.; Cheng, G.; Bever, J. D.; Johannesson, H.; Rosling, A.
10.1101/2023.04.18.537338 — evolutionary biology — Posted on 2025-02-26
672 Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease
Albarran-Juarez, J.; Markov, A.; Jensen, A. L.; Moller, P. L.; Uryga, A. K.; Djordjevic, D.; Hansen, J.; Jensen, L. F.; Sharysh, D.; Pyke, C.; Moreno, J.; Borghetti, G.; Bachmann, J.; Herum, K.; Roge, L. M.; Traylor, M.; Nyberg, M.; Nyegaard, M.; Bentzon, J. F.
10.1101/2024.11.11.623011 — cell biology — Posted on 2025-02-26
673 Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection
Cheng, M. T. K.; Altaf, M.; Castin, J.; Reuschl, A.-K.; Sievers, B. L.; Kamelian, K.; Mesner, D.; Morse, R. B.; Abdullahi, A.; Meng, B.; Csiba, K.; Cambridge NIHR Bioresource, ; Kemp, S. A.; Martin, D. P.; Jolly, C.; Ruis, C.; Thukral, L.; Gupta, R. K.
10.1101/2024.09.05.611549 — immunology — Posted on 2025-02-26
675 Cell Function Graphics: TOGGLE delineates fate and function within individual cell types via single-cell transcriptomics
Chen, J.; Chen, Z.; Sun, T.; Jiang, E.; Liu, K.; Nong, Y.; Yuan, T.; Daga, P.; Dai, C. C.; Yan, Y.; Ge, J.; Wu, H.; Yang, T.; Wang, S.; Su, Z.; Song, T.; Abdelbsset-Ismail, A.; Li, Y.; Li, C.; Singhal, R. A.; Yang, K.; Carll, A. P.
10.1101/2025.01.01.631041 — bioinformatics — Posted on 2025-02-26
678 Unraveling the mystery behind the short-day-specific flowering of tobacco cultivar Maryland Mammoth
Grundmann, L.; Zimmermann, M. M.; Kaenel, A.; Schwarze, A.; Wiedmann, D. R.; Muth, J.; Twymann, R. M.; Pruefer, D.; Noll, G. A.
10.1101/2022.06.27.497884 — plant biology — Posted on 2025-02-26
679 An unexplored diversity for adaptation of germination to high temperatures in Brassica species
Tiret, M.; Wagner, M.-H.; Gay, L.; Chenel, E.; Dupont, A.; Falentin, C.; Maillet, L.; Gavory, F.; Labadie, K.; Ducournau, S.; Chevre, A.-M.
10.1101/2024.10.22.619588 — evolutionary biology — Posted on 2025-02-26
681 Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
John, N.; Fleming, T.; Kolb, J.; Lyraki, O.; Vasquez-Sepulveda, S.; Parmar, A.; Kim, K.; Tarczewska, M.; Gupta, P.; Singh, K.; Marini, F.; Singh, S. P.; Falk, S.; Franze, K.; Guck, J.; Wehner, D.
10.1101/2025.01.27.635043 — neuroscience — Posted on 2025-02-26
682 CA2/3-dependent stability of frontoparietal mnemonic representations predicts episodic deficits in human amnesia
Miller, T. D.; Hickling, A. L.; Wu, Y. I.; Zhou, J. H.; Handel, A. E.; Coutinho, E.; Pollak, T. A.; Zandi, M. S.; Rosenthal, C. R.; Maguire, E. A.
10.1101/2025.02.19.638996 — neuroscience — Posted on 2025-02-26
684 Deep learning for fluorescence lifetime predictions enables high-throughput in vivo imaging
Kapsiani, S.; Läubli, N. F.; Ward, E. N.; Fernandez-Villegas, A.; Mazumder, B.; Kaminski, C. F.; Kaminski Schierle, G. S.
10.1101/2025.02.20.639036 — biophysics — Posted on 2025-02-26
686 Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
Gholamalamdari, O.; van Schaik, T.; Wang, Y.; Kumar, P.; Zhang, L.; Zhang, Y.; Gonzalez, G. A. H.; Vouzas, A. E.; Zhao, P. A.; Gilbert, D. M.; Ma, J.; van Steensel, B.; Belmont, A. S.
10.1101/2024.04.23.590809 — genomics — Posted on 2025-02-26
687 A scalable approach to investigating sequence-to-expression prediction from personal genomes
Spiro, A. E.; Tu, X.; Sheng, Y.; Sasse, A.; Hosseini, R.; Chikina, M.; Mostafavi, S.
10.1101/2025.02.21.639494 — genomics — Posted on 2025-02-26
688 A comparative approach for selecting orthologous candidate genes in genome-wide associationstudies across multiple species
Whitt, L.; Mahood, E. H.; Ziegler, G.; Luebbert, C.; Gillman, J. D.; Norton, G. J.; Price, A. H.; Salt, D. E.; Dilkes, B.; Baxter, I.
10.1101/2023.10.05.561051 — genetics — Posted on 2025-02-26
690 Maximizing immunopeptidomics-based bacterial epitope discovery by multiple search engines and rescoring
Willems, P.; Thery, F.; Van Moortel, L.; De Meyer, M.; Staes, A.; Gul, A.; Kovalchuke, L.; Declercq, A.; Devreese, R.; Bouwmeester, R.; Gabriels, R.; Martens, L.; Impens, F.
10.1101/2024.11.22.624860 — molecular biology — Posted on 2025-02-26
691 Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae
Mai, N.; Bauda, E.; Boyat, C.; Laguri, C.; Freton, C.; Chouquet, A.; Gallet, B.; Baudoin, M.; Wong, Y.-S.; Grangeasse, C.; Moriscot, C.; Durmort, C.; Zapun, A.; Morlot, C.
10.1101/2024.10.18.619035 — microbiology — Posted on 2025-02-26
693 Protozoal populations drive system-wide variation in the rumen microbiome
Kobel, C. M.; Leu, A.; Vera-Ponce de Leon, A.; Oyas, O.; Lai, W.; Altshuler, I.; Hagen, L. H.; Wollenberg, R. D.; Sondergaard, M. T.; Bakshani, C. R.; Willats, W. G. T.; Nicoll, L.; McIlroy, S. J.; Hvidsten, T. R.; Schmidt, O.; Greening, C.; Tyson, G. W.; Roehe, R.; Aho, V. T. E.; Pope, P. B.
10.1101/2024.12.05.626740 — microbiology — Posted on 2025-02-26
697 Quantifying Variability in Attentional Shifts During Target Switching Using Steady-State Visual Evoked Potentials
Eidelman-Rothman, M.; Reuveni, O.; Keil, A.; Kritzman, L.; Freche, D.; Okon-Singer, H.; Levit-Binnun, N.
10.1101/2023.10.21.563393 — neuroscience — Posted on 2025-02-26
704 How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization
Gemeinhardt, T. M.; Regy, R. M.; Phan, T. M.; Pal, N.; Sharma, J.; Senkovich, O.; Mendiola, A. J.; Ledterman, H. J.; Henrickson, A.; Lopes, D.; Kapoor, U.; Bihani, A.; Sihou, D.; Kim, Y. C.; Jeruzalmi, D.; Demeler, B.; Kim, C. A.; Mittal, J.; Francis, N. J.
10.1101/2023.10.26.564264 — biochemistry — Posted on 2025-02-26
705 Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery
Tastemel, M.; Jussila, A. P.; Saravanan, B.; Huang, H.; Xie, Y.; Zhu, Q.; Jiang, Y.; Armand, E.; Ren, B.
10.1101/2025.02.21.639596 — genomics — Posted on 2025-02-26
706 Beyond guilty by association at scale: searching for causal variants on the basis of genome-wide summary statistics
He, Z.; Chu, B.; Yang, J.; Gu, J.; Chen, Z.; Liu, L.; Morrison, T.; Belloy, M. E.; Qi, X.; Hejazi, N.; Mathur, M.; Le Guen, Y.; Tang, H.; Hastie, T.; Ionita-laza, I.; Candes, E.; Sabatti, C.
10.1101/2024.02.28.582621 — genetics — Posted on 2025-02-26
710 Trade-offs associated with higher winter wheat yields in low soil organic matter cropping systems under climate change
Michel, J.; Leemans, V.; Weinmann, M.; Balanzategui-Guijarro, I.; Bin, J.; Biver, S.; Blum, A.; Borger, R.; Him, S. L.; Kirbas, G.; Le Gouis, J.; Moya-Larano, J.; Persyn, M.; Pierreux, J.; Quenon, A.; Sanchez-Moreno, S.; Symanczik, S.; Vanden Brande, F.; Van Der Straeten, D.; Wagner, M.; Waibel, M.; Xayphrarath, A.; Vanderschuren, H.; Thonar, C.; Delaplace, P.
10.1101/2024.11.30.626142 — ecology — Posted on 2025-02-26
711 Macrophages promote collagen deposition through circadian regulation of fibroblasts
Lowles, K.; Cutiongco, M. F.; Hughes, J. J.; Li, S.; Knox, J.; Coy, M.; Lin, W.-H.; MacDonald, A. S.; Kadler, K.; Meng, Q.-J.; Hussell, T.; Chang, J.
10.1101/2025.02.25.640115 — cell biology — Posted on 2025-02-26
712 Assessment of the Histone Mark-based Epigenomic Landscape in Human Myometrium at Term Pregnancy
Wu, S. P. S.; Quiroz, E.; Wang, T.; Redecke, S. M.; Xu, X.; Lin, L.; Anderson, M.; DeMayo, F.
10.1101/2024.02.19.581035 — cell biology — Posted on 2025-02-26
713 Multi-omic subtypes of Alzheimer's dementia are differentially associated with psychological traits
Zammit, A. R.; Yu, L.; Poole, V. N.; Arfanakis, K.; Schneider, J. A.; Petyuk, V. A.; De Jager, P.; Kaddurah-Daouk, R.; Iturria-Medina, Y.; Bennett, D. A.
10.1101/2025.02.21.639584 — molecular biology — Posted on 2025-02-26
715 A Dapl1+ subpopulation of naive CD8 T cells contains committed precursors of memory lineage.
Lynch, A. C.; Hioki, K. A.; Liang, X.; Thesmar, I.; Cernjul, J.; He, X.; Mager, J.; Cui, W.; Alfandari, D.; Pobezinskaya, E. E.; Pobezinsky, L. A.
10.1101/2025.02.06.636941 — immunology — Posted on 2025-02-26
716 Untangling dopamine and glutamate in the ventral tegmental area
Prevost, E. D.; Ward, L. A.; Alas, D.; Aimale, G.; Ikenberry, S.; Fox, K.; Pelletier, J.; Ly, A.; Ball, J.; Kilpatrick, Z. P.; Price, K.; Polter, A. M.; Root, D. H.
10.1101/2025.02.25.640201 — neuroscience — Posted on 2025-02-26
718 iPSC-Derived Cerebral Organoids Reveal Mitochondrial, Inflammatory and Neuronal Vulnerabilities in Bipolar Disorder
El Soufi El Sabbagh, D.; Kolinski Machado, A.; Pappis, L.; Beroncal, E.; Ji, D.; Nader, G.; Ravi Chander, P.; Choi, J.; Duong, A.; Jeong, H.; Panizzutti Parry, B.; Bortolasci, C.; Szatmari, A.; Carlen, P.; Hahn, M.; Attisano, L.; Berk, M.; Walder, K. R.; Andreazza, A.
10.1101/2025.02.25.640229 — neuroscience — Posted on 2025-02-26
719 Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix
Nguyen, P. T.; Tamura, S.; Sun, E.; Shi, Y.; Xiao, Y.; Lacefield, C.; Turi, G.; Hen, R.
10.1101/2025.01.03.631260 — neuroscience — Posted on 2025-02-26
721 Arousal threshold reveals novel neural markers of sleep depth independently from the conventional sleep stages
Picchioni, D.; Yang, F. N.; de Zwart, J. A.; Wang, Y.; Mandelkow, H.; Ozbay, P. S.; Chen, G.; Taylor, P. A.; Lam, N.; Chappel-Farley, M. G.; Chang, C.; Liu, J.; van Gelderen, P.; Duyn, J. H.
10.1101/2024.08.09.607376 — neuroscience — Posted on 2025-02-26
724 Movie-watching evokes ripple-like activity within events and at event boundaries
Silva, M.; Wu, X.; Sabio, M.; Conde-Blanco, E.; Roldan, P.; Donaire, A.; Carreno, M.; Axmacher, N.; Baldassano, C.; Fuentemilla, L.
10.1101/2023.09.27.559739 — neuroscience — Posted on 2025-02-26
725 A TNL receptor mediates microbiome feedbacks in Arabidopsis
Janse van Rensburg, H.; Schandry, N.; Waelchli, J.; Stengele, K.; Cadot, S.; Jandrasits, K.; Becker, C.; Schlaeppi, K.
10.1101/2025.02.25.640125 — plant biology — Posted on 2025-02-25
727 Future flooding tolerant rice germplasm: resilience afforded beyond Sub1A gene
Anumalla, M.; Khanna, A.; Catolos, M.; Ramos, J.; Sta. Cruz, M. T.; Venkateshwarlu, C.; Konijerla, J.; Pradhan, S. K.; Dash, S. K.; Das, Y.; Chowdhury, D.; Chetia, S. K.; Das, J.; Nath, P.; Merugumala, G. R.; Roy, B.; Pradhan, N.; Jana, M.; Dana, I.; Debnath, S.; Nath, A.; Prasad Singh, S.; Iftekharuddaula, K. M.; Ghosal, S.; Ali, M.; Khanam, S.; Ul Islam, M. M.; Faruquee, M.; Tonny, H. J.; Hasan, M. R.; Rahman, A.; Ali, J.; Sinha, P.; Singh, V.; Rafiqul Islam, M.; Bhosale, S.; Kohli, A.; Bhardwaj, H. R.; Hussain, W.
10.1101/2025.02.24.639789 — plant biology — Posted on 2025-02-25
729 Estropausal gut microbiota transplant improves measures of ovarian function in adult mice
Kim, M.; Wang, J.; Pilley, S. E.; Lu, R. J.; Xu, A.; Kim, Y.; Liu, M.; Fu, X.; Booth, S. L.; Mullen, P. J.; Benayoun, B. A.
10.1101/2024.05.03.592475 — physiology — Posted on 2025-02-26
730 Early and late RNA eQTL are driven by different genetic mechanisms
Sakaue, S.; Accelerating Medicines Partnership: RA/SLE Network, ; Raychaudhuri, S.
10.1101/2025.02.24.639351 — genomics — Posted on 2025-02-26
735 Multi-view gene panel characterization for spatially resolved omics
Kim, D.; Ding, W.; Shaw, A. N.; Torkel, M.; Turtle, C. J.; Yang, P.; Yang, J. Y. H.
10.1101/2025.02.19.639174 — bioinformatics — Posted on 2025-02-25
736 Enhancing tandem MS sensitivity and peptide identification via ion pre-accumulation in an Orbitrap mass spectrometer
Harking, F.; Guzman, U. H.; Kraegenbring, J.; STEWART, H.; Ayzikov, K.; Koch, H.; Fort, K. L.; Harder, A.; Olsen, J. V.
10.1101/2025.02.20.639277 — biochemistry — Posted on 2025-02-25
738 Calcium starvation leads to strain-specific gene regulation of lipid and carotenoid production in Mucor Circinelloides
Baalsrud, H. T.; Byrtusova, D.; To, T.-H.; Larsen, I. E.; Boe, V. A.; Gronvold, L.; Fu, J.; Arnyasi, M.; Shapaval, V.; Sandve, S. R.
10.1101/2025.02.20.639118 — genomics — Posted on 2025-02-25
739 Seasonal Phenology of Empoasca fabae (Hemiptera: Cicadellidae) in Quebec, Canada
Almeida Santos, A.; Vieira Araujo, F. H.; Plante, N.; Siqueira da Silva, R.; Perez-Lopez, E.
10.1101/2025.02.21.639576 — ecology — Posted on 2025-02-25
740 Single-cell omics-based characterization of human basophils reveals two transcriptionally distinct populations
Papavasileiou, S.; Mo, J.; Boey, D.; Wu, C.; Tronstad, M.; Olsen, R.-A.; Bachmann, J. A.; Low, J. H.; Ong, J.; Blom, L. H.; Andiappan, A. K.; Nilsson, G.; Dahlin, J. S.
10.1101/2025.02.20.639059 — immunology — Posted on 2025-02-25
742 Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
Bhattacharya, A.; Stutvoet, T. S.; Perla, M.; Loipfinger, S.; Jalving, M.; Reyners, A. K. L.; Vermeer, P. D.; Drapkin, R.; de Bruyn, M.; de Vries, E. G. E.; de Jong, S.; Fehrmann, R. S. N.
10.1101/2024.10.21.619015 — cancer biology — Posted on 2025-02-25
743 Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos
Yamamoto, K.; Ichbiah, S.; Perez, M.; Borrego-Pinto, J.; Delbary, F.; Goehring, N.; Turlier, H.; Charras, G.
10.1101/2023.03.07.531437 — biophysics — Posted on 2025-02-25
744 Characterizing 3D RNA structural features from DMS reactivity
Deenalattha, S.; Jurich, C. P.; Lange, B.; Armstrong, D.; Nein, K.; Yesselman, J. D.
10.1101/2024.11.21.624766 — biochemistry — Posted on 2025-02-25
746 Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins
May, A. J.; Lella, M.; Lindenberger, J.; Berkman, A.; Kumar, U.; Dutta, M.; Barr, M.; Parks, R.; Newman, A.; Huang, X.; Song, K.; Ilevbare, V.; Sammour, S.; Park, C. S.; Adhikari, R. D.; Devkota, P.; Janowska, K.; Liu, Y.; Scapellato, G.; Spence, T. N.; Mansouri, K.; Edwards, R. J.; Saunders, K. O.; Haynes, B. F.; Acharya, P.
10.1101/2024.12.11.627382 — biochemistry — Posted on 2025-02-25
748 Unraveling genetic load dynamics during biological invasion: insights from two invasive insect species
Lombaert, E.; Blin, A.; Porro, B.; Guillemaud, T.; Bernal, J. S.; Chang, G.; Kirichenko, N.; Sappington, T. W.; Toepfer, S.; Deleury, E.
10.1101/2024.09.02.610743 — evolutionary biology — Posted on 2025-02-25
751 Bacterial inoculation elicits changes to the coral epigenome
Barno, A. R.; Villela, H. D.; Cardoso, P. M.; Garcia, F. C.; Cui, G.; Delgadillo-Ordonez, N.; Rosado, A. S.; Thomas, T.; Aranda, M.; Voolstra, C. R.; Peixoto, R.
10.1101/2024.10.27.620496 — molecular biology — Posted on 2025-02-25
752 HIV-1 Vpr alters cellular transcription by targeting the PAF1 complex
Biguet, M.; Marno, K.; Oliveira, N.; Gibbons, J. M.; Pade, C.; Jones, C. E.; Branco, M. R.; McKnight, A.
10.1101/2024.12.18.629146 — microbiology — Posted on 2025-02-25
753 Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity
Hoyt-Miggelbrink, A.; Waibl Polania, J.; Wachsmuth, L.; Lorrey, S. J.; Mohan, A.; Hardigan, A. A.; Blandford, E.; Lerner, E.; Wilkinson, D.; Hotchkiss, K.; Cook, S.; Hemmers, S.; Patel, A.; Ayasoufi, K.; Fecci, P. E.
10.1101/2024.07.12.603311 — immunology — Posted on 2025-02-25
754 Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences
Wang, N.; Wang, Y.; Guo, M.; Wang, L.; Wang, X.; Zhu, N.; Yang, J.; Wang, L.; Zheng, C.; Ming, D.
10.1101/2024.03.27.586908 — neuroscience — Posted on 2025-02-25
755 MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
Guerin, C. M.; Vinchent, A.; Fernandes, M.; Damour, I.; Laratte, A.; Tellier, R.; Estevam, G. O.; Meneboo, J.-P.; Villenet, C.; Descarpentries, C.; Fraser, J. S.; Figeac, M.; Cortot, A. B.; Rouleau, E.; Tulasne, D.
10.1101/2023.11.03.565283 — cancer biology — Posted on 2025-02-25
757 Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
Goldman, O. V.; DeFoe, A. E.; Qi, Y.; Jiao, Y.; Weng, S.-C.; Houri-Zeevi, L.; Lakhiani, P.; Morita, T.; Razzauti, J.; Rosas-Villegas, A.; Tsitohay, Y. N.; Walker, M.; Hopkins, B. R.; Mosquito Cell Atlas Consortium, ; Joshua X D Ang, ; Igor Antoshechkin, ; Yu Cai, ; Fangying Chen, ; Yen-Chung Chen, ; Julien Devilliers, ; Linhan Dong, ; Roberto Feuda, ; Paolo Gabrieli, ; Artyom Kopp, ; Hyeogsun Kwon, ; Hsing-Han Li, ; Tzu-Chiao Lu, ; Thalita Lucio, ; Joao T Marques, ; Marcus F Oliveira, ; Roenick P Olmo, ; Umberto Palatini, ; Zeaan M Pithawala, ; Julien Pompon, ; Yan Reis,
10.1101/2025.02.25.639765 — genomics — Posted on 2025-02-25
758 Two interconnected patterning loops are required for body axis and head organizer formation in Hydra
Mercker, M.; Tursch, A.; Veerman, F.; Kazarnikov, A.; Höger, S.; Lengfeld, T.; Özbek, S.; Holstein, T. W.; Marciniak-Czochra, A.
10.1101/2021.02.05.429954 — developmental biology — Posted on 2025-02-25
759 Autophagy across tissues of aging mice
Carosi, J. M.; Martin, A.; Hein, L. K.; Hassiotis, S.; Hattersley, K. J.; Turner, B. J.; Fourrier, C.; Bensalem, J.; Sargeant, T. J.
10.1101/2024.09.11.612427 — cell biology — Posted on 2025-02-25
760 Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation
Li, H.; Ishizaki, I.; Kato, K.; Sun, X.; Muramatsu, S.; Itou, H.; Ose, T.; Araki, H.; Yao, M.
10.1101/2024.08.29.610416 — molecular biology — Posted on 2025-02-25
761 Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys
Pitts, J.; Zamora, J. L. R.; Manhas, S.; Aeschbacher, T.; Chan, J.; Cutillas, V.; Nair, V.; Riola, N. C.; Vijjapurapu, A.; Vermillion, M. S.; Eng, S.; Richards, C.; Han, D.; Perry, J. K.; Chaudhuri, S.; Liu, I.; Martinez, C.; Peinovich, N.; Sun, K.-H.; Cai, A.; Martin, R.; Moshiri, J.; Hedskog, C.; Babusis, D.; Siegel, D. S.; Kalla, R.; Avadhanula, V.; Piedra, P. A.; Stobbelaar, K.; Delputte, P. L.; Marceau, C.; Mateo, R.; Svarovskaia, J.; Mo, H.; Subramanian, R.; Mackman, R. L.; Cihlar, T.; Fletcher, S. P.; Bilello, J. P.
10.1101/2025.02.24.639976 — microbiology — Posted on 2025-02-25
762 Membrane-permeable 5-fluorodeoxyuridine triphosphate derivatives inhibit the proliferation of Plasmodium falciparum
Nikolova, V.; Linnemannstoens, K.; Bendel, M.-E.; Machado, M.; Ganter, B.; Budimir, P.; Vogts, M.; Ganter, M.; Meier, C.; Dobbelstein, M.
10.1101/2025.02.25.640175 — microbiology — Posted on 2025-02-25
764 Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years.
de Zwaan, R.; de Vries, G.; Ubbelohde, E.; Mulder, A.; Kamst-van Agterveld, M.; Rebel, K.; Kautz, S.; Kremer, K.; Anthony, R.; van Soolingen, D.
10.1101/2025.02.07.637016 — microbiology — Posted on 2025-02-25
765 Endothelial-leukocyte interaction in CAR T cell neurotoxicity
Park, L.; Tsai, Y.-T.; Lim, H.-K.; Faulhaber, L. D.; Burleigh, K.; Faulhaber, E. M.; Bose, M.; Shih, A. Y.; Hirayama, A. V.; Turtle, C. J.; Annesley, C. E.; Gardner, R. A.; Gustafson, H. H.; Gust, J.
10.1101/2025.02.19.638920 — immunology — Posted on 2025-02-25
766 Literature-scaled immunological gene set annotation using AI-powered immune cell knowledge graph (ICKG)
He, S.; Tan, Y.; Mohanty, V.; Ye, Q.; Gubin, M.; Rafei, H.; Peng, W.; Rezvani, K.; Chen, K.
10.1101/2025.02.19.639172 — bioinformatics — Posted on 2025-02-25
769 Biaxial testing and sensory texture evaluation of plant-based and animal deli meat
St. Pierre, S. R.; Somersille Sibley, L.; Tran, S.; Tran, V.; Darwin, E. C.; Kuhl, E.
10.1101/2025.02.19.639170 — bioengineering — Posted on 2025-02-25
770 Differential O-Glc elongation on the specific EGF repeat within a ligand binding domain regulates NOTCH1 signaling
Tsukamoto, Y.; Aoki, K.; Saiki, W.; Tsukamoto, N.; Kato, K.; Hosokawa, Y.; Sato, R.; Fujita, Y.; Fukazawa, K.; Kurebayashi, Y.; Urata, Y.; Uchiyama, S.; Wang, W.; Minami, A.; Takahashi, T.; Tiemeyer, M.; Narimatsu, Y.; Okajima, T.; Takeuchi, H.
10.1101/2025.02.20.639268 — biochemistry — Posted on 2025-02-25
772 RNA Transcripts Serve as a Template for Double-Strand Break Repair in Human Cells
sfeir, a.; Powell, S. N.; Jalan, M.; Brambati, A.; Shah, H.; McDermott, N.; Zhu, Y.; Patel, J.; Doymaz, A.; Wu, J.; Anderson, K. S.; Gazzo, A.; Pareja, F.; Yamaguchi, T. N.; Vougiouklakis, T.; Ahmed-Seghir, S.; Steinberg, P.; Neiman-Golden, A.; Azeroglu, B.; Gomez-Aguilar, J.; da Silva, E. M.; Hussain, S.; Higginson, D.; Boutros, P. C.; Riaz, N.; Reis-Filho, J. S.
10.1101/2025.02.23.639725 — molecular biology — Posted on 2025-02-25
773 Promiscuous endosymbionts in deep-sea corals and crinoids are shaped by nitrogen cycling
Modolon, F.; Garritano, A. N.; Hill, L. J.; Duarte, G.; Bendia, A. G.; Moura, R. B.; Pellizari, V. H.; Thomas, T.; Peixoto, R.
10.1101/2025.02.25.640168 — microbiology — Posted on 2025-02-25
775 Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in mice
Hendrix, J.; Mubarak, R. A.; Bateman, A.; Massoudi, L. M.; Rossmassler, K.; Kaya, F.; Zimmerman, M. D.; Wynn, E. A.; Voskuil, M. I.; Robertson, G. T.; Moore, C. M.; Walter, N. D.
10.1101/2025.02.25.640123 — microbiology — Posted on 2025-02-25
776 Mass mortality events in the sub-Antarctic Indian Ocean caused by long-distance circumpolar spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b
Clessin, A.; Briand, F.-X.; Tornos, J.; Lejeune, M.; De Pasquale, C.; Fischer, R.; Souchaud, F.; Hirchaud, E.; Bralet, T.; Guinet, C.; McMahon, C. R.; Grasland, B.; Baele, G.; Boulinier, T.
10.1101/2025.02.25.640068 — microbiology — Posted on 2025-02-25
777 Keratinocyte Arginase1 Deficiency Impairs Healing and Antimicrobial Defence against Pseudomonas aeruginosa Infection
Crompton, R. A.; Szondi, D. C.; Doherty, C.; Thomason, H. A.; Lee, S. H.; Ping, L. Y.; O'Neill, C. A.; Vardy, L.; McBain, A. J.; Cruickshank, S. M.
10.1101/2025.02.24.640016 — microbiology — Posted on 2025-02-25
778 Gut Microbiome Signatures Reflect Within-Host Subtype Diversity of Blastocystis in Non-Human Primates
Wang, S.; Ma, P.-P.; Mu, W.; Wang, Y.; Liu, Y.; Zou, Y.; Pan, H.; Zhang, L.; Chen, L.; Yang, Y.; Luo, W.
10.1101/2025.02.25.640083 — microbiology — Posted on 2025-02-25
781 MsyB-HU Interaction Modulates a Two-Tiered Bacterial Stress Response by Regulating DNA Supercoiling
Chen, H.; Yang, Y.; Chen, X.; Zhou, H.; He, Y.; Li, M.; Lin, W.; Wang, Y.; Matthews, S.; Yuan, S.; Wang, H.; LIU, B.
10.1101/2025.02.25.640118 — microbiology — Posted on 2025-02-25
782 Endogenous structure of antimalarial target PfATP4 reveals new class of apicomplexan P-type ATPase modulators
Haile, M. T.; Shukla, A.; Zhen, J.; Mather, M. W.; Bhatnagar, S.; Zhang, Z.; Vaidya, A. B.; Ho, C.-M.
10.1101/2025.02.25.640208 — microbiology — Posted on 2025-02-25
784 Cryptosporidium modifies intestinal microvilli through an exported virulence factor
Rodrigues, E.; Pallett, M. A.; Straker, L. C.; Mkandawire, T. T.; Sala, K.; Collinson, L.; Sateriale, A.
10.1101/2025.02.25.639898 — microbiology — Posted on 2025-02-25
787 Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism
Kumar, A.; Kishimoto, K.; Goel, H. L.; Wisniewski, C.; Li, R.; Pacheco, B.; Zhu, L. J.; Flavahan, W. A.; Mercurio, A. M.
10.1101/2025.02.19.638943 — cancer biology — Posted on 2025-02-25
788 Deletion of core septin gene aspB in Aspergillus fumigatus results in fungicidal activity of caspofungin
Busch, R. J.; Doty, C.; Mills, C. A.; Latifi, F.; Herring, L. E.; Konjufca, V.; Vargas-Muniz, J. M.
10.1101/2025.02.25.640155 — microbiology — Posted on 2025-02-25
796 ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenance
Kumar, S.; Fan, X.; Pattam, H.; Yan, K.; Liaw, E.; Ji, J.; Zaltz, E.; Song, P.; Jiang, Y.; Nishizaki, Y.; Higashi, Y.; Cai, C.-L.; Lu, W.
10.1101/2025.02.23.639741 — developmental biology — Posted on 2025-02-25
800 Ketogenic interventions prevent alterations of the gut microbiome in transgenic Alzheimer Disease mice
M'Bra, P. E. H.; Avino, M.; Lim, E. N. K.; Mayhue, M.; Balthazar, P.; Aumont, A.; Prevost, K.; Masse, E.; Fernandes, K.
10.1101/2025.02.25.640129 — neuroscience — Posted on 2025-02-25
801 Lifespan Mapping of EEG Source Spectral Dynamics with Xi-AlphaNET
Reyes, R. G.; Gonzales, A. A.; Wang, Y.; Jin, Y.; Minati, L.; Valdes-Sosa, P. A.
10.1101/2025.02.21.639413 — neuroscience — Posted on 2025-02-25
803 MuFIX - Enabling Combinations of Concurrent Optogenetics and Lock-in Amplification Fiber Photometry via Removal of Optogenetic Stimulation Crosstalk
Breakstone, M.; Chen, S.; Vadapalli, S.; Chavez, E.; Parsonnet, L. S.; Gross, R. E.; Tescarollo, F.; Barker, D. J.; Sun, H.
10.1101/2025.02.23.639738 — neuroscience — Posted on 2025-02-25
805 Morphine self-administration induces region-specific brain volume changes and microglial phenotypic alterations without affecting neuronal density in male Wistar rats
Elizarraras-Herrera, A. D.; Medina-Sanchez, D.; Serrano-Ramirez, M. S.; Angeles Valdez, D.; Trujillo-Villarreal, L. A.; Carbajo-Mata, M. A.; Carranza-Aguilar, C.; Garza-Villarreal, E. A.
10.1101/2025.02.20.639378 — neuroscience — Posted on 2025-02-25
807 Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Farrell, C.; Buhidma, Y.; Mumford, P.; Heywood, W. E.; Hallqvist, J.; Flores-Aguilar, L.; Andrews, E.; Rahimzadah, N.; Taso, O. S.; Doran, E.; Swarup, V.; Head, E.; Lashley, T.; Mills, K.; Toomey, C. E.; Wiseman, F. K.
10.1101/2025.02.24.639862 — neuroscience — Posted on 2025-02-25
809 Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits
Koh, M.; Anselmi, F.; Kaushalya, S. K.; Hernandez, D. E.; Bast, W. G.; Villar, P. S.; Chae, H.; Davis, M. B.; Teja, S. S.; Qu, Z.; Gradinaru, V.; Gupta, P.; Banerjee, A.; Albeanu, D. F.
10.1101/2025.02.24.639992 — neuroscience — Posted on 2025-02-25
811 PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease
Comandante-Lou, N.; Lama, T. D.; Chen, K. W.; Zhang, J.; Hu, B.; Liu, S.; Heuer, S. E.; Brennand, K. J.; Schneider, J. A.; Barnes, L. L.; Zhang, B.; Wang, M.; Zou, H.; Friedel, R. H.; Ma, Y.; Young-Pearse, T.; Li, A.; Fujita, M.; Bennett, D. A.; Zhang, Y.; Menon, V.; Klein, H.-U.; Taga, M. F.; De Jager, P. L.
10.1101/2025.02.24.639868 — neuroscience — Posted on 2025-02-25
814 Development and Characterization of a Sf-1-Flp Mouse Model
Galvan, M.; Fujitani, M.; Heaselgrave, S. R.; Thomas, S.; Wyler, S. C.; Chen, B.; Lee, J. J.; Elmquist, J. K.; Fujikawa, T.
10.1101/2025.02.21.639566 — neuroscience — Posted on 2025-02-25
815 Motivating Effects of Negative-hedonic Valence Encoded in Engrams
Nedelescu, H.; Meamari, E.; Rajaei, N.; Grey, A.; Bullard, R.; OConnor, N.; Suto, N.; Weiss, F.
10.1101/2025.02.21.639600 — neuroscience — Posted on 2025-02-25
819 Astrocytic activation of EMMPRIN contributes to their pathological phenotype in ALS.
Edozie, G. N.; Belanger, J.; Pigeyre, S.; Gosselin, A.; Boyer, M.; Godin, A. G.; Pozzi, S.
10.1101/2025.02.23.639749 — neuroscience — Posted on 2025-02-25
820 Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke
Lee, H. K.; LIN, C.-C.; Dunn, D. E.; Chen, Y.; Chen, S.-Y.; Marchuk, D. A.; Floyd, S. R.; Chi, J.-T. A.
10.1101/2025.02.22.639635 — neuroscience — Posted on 2025-02-25
822 Splanchnic and pelvic spinal afferent pathways relay sensory information from the mouse colorectum into distinct brainstem circuits.
Wang, Q.; McGovern, A. E.; Kyloh, M. A.; Rychkov, G.; Spencer, N. J.; Mazzone, S. B. M.; Brierley, S. M.; Harrington, A. M.
10.1101/2025.02.24.639793 — neuroscience — Posted on 2025-02-25
823 A humanized mouse model system mimics prenatal Zika infection and reveals premature differentiation
Horvath, A. R.; Abdelmalek, C. M.; Park, E.; Alexander, A. P.; Maheswaran, S. A.; Patel, A. H.; Patel, N. G.; Ruan, J. E.; Adeyemo, A. T.; Li, E. C.; Helmicki, K. E.; Lin, S.; Wang, P. C.; Li, Z.; Wang, L.; Gordish-Dressman, H. A.; Haydar, T. F.; Mansour, T. A.; Kousa, Y.
10.1101/2025.02.21.639556 — neuroscience — Posted on 2025-02-25
825 Data retention in awake infant fMRI: Lessons from more than 750 scanning sessions
Behm, L.; Yates, T. S.; Trach, J. E.; Choi, D.; Du, H.; Osumah, C.; Deen, B.; Kosakowski, H. L.; Chen, E. M.; Kamps, F. S.; Olson, H. A.; Ellis, C. T.; Saxe, R.; Turk-Browne, N. B.
10.1101/2025.02.20.636736 — neuroscience — Posted on 2025-02-25
828 Satiety, TAX-4, and OSM-9 Tune the Attraction of C. elegans Nematodes to Microbial Fermentation Products
Logan-Garbisch, T.; Fryer, E.; Rogel-Hernandez, L.; Seyahi, L. S.; Rhee, S. Y.; Goodman, M. B.
10.1101/2025.02.21.639594 — neuroscience — Posted on 2025-02-25
830 Investigating the effectiveness of cannabidiol to mitigate the adverse consequences of exposure to neonatal procedural pain
Timmerman, B.; Honeycutt, J. A.; Skully, J.; Patel, D.; Kahn, W.; Neagu, A.; Baez, E.; Battagliese, Q.; Brummelte, S.
10.1101/2025.02.21.639541 — neuroscience — Posted on 2025-02-25
832 Loss of Sarm1 Mitigates Axonal and Neuronal Degeneration and Promotes Neuronal Repair After Ischemic Stroke
Wang, J. T.; Toh, B.; An, J.; Komuro, Y.; Godoy, M. I.; Putman, J.; Carmichael, S. T.; Damoiseaux, R.; Hinman, J. D.
10.1101/2025.02.20.639171 — neuroscience — Posted on 2025-02-25
834 Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues
Murakami, T. C.; Belenko, N.; Dennis, G.; Wang, C.; Siantoputri, M. E.; Maeda, Y.; Pressl, C.; Heintz, N.
10.1101/2025.02.24.639965 — neuroscience — Posted on 2025-02-25
835 D-LMBmapX: Generalized Deep-Learning Pipeline for Automated Whole-brain Neural Circuitry Profiling Across Any Developmental Stages
Li, Z.; Li, P.; Pan, H.; Adams, A. M. J.; Huang, Z.; Liu, H.; Li, J.; Su, Y.; Zhong, B.; Bray, L.; Sturgess, R. N.; Zhu, J.; Zhang, D.; Zhang, S.; Ren, J.
10.1101/2025.02.25.639766 — neuroscience — Posted on 2025-02-25
839 Multimodal characterization and optogenetic potential of the bistable Gi/o-coupled vertebrate ancient opsin from the flashlight fish Anomalops katoptron
Rohr, L.; Zhornist, D.; Berman, O.; Ruse, C.; Seidenthal, M.; Auger, G. M.; Naber, C.; Kirchhof, A.; Gueers, C.; Mark, M. D.; Rudack, T.; Soba, P.; Gottschalk, A.; Shalev-Benami, M.; Siveke, I.; Herlitze, S.
10.1101/2025.02.20.639284 — neuroscience — Posted on 2025-02-25
841 Sleep Resolves Competition Between Explicit and Implicit Memory Systems
Kleespies, K.; Paulus, P. C.; Zhu, H.; Pargent, F.; Jakob, M.; Werle, J.; Czisch, M.; Boedecker, J.; Gais, S.; Schonauer, M.
10.1101/2025.02.21.639581 — neuroscience — Posted on 2025-02-25
842 Designing new natural-mimetic phosphatidic acid: aversatile and innovative synthetic strategy forglycerophospholipid research
Schlichter, A.; Wolf, A.; Ferrand, T.; Cocq, A.; Riachy, L.; Vertueux, S.; Beauvais, B.; Courvalet, M.; Henri, P.-J.; Tanguy, E.; Gonzales, L.; Ferlet, R.; Laguerre, F.; Decraene, C.; Pellissier, A.; Sebban, M.; Sabot, C.; Jeandel, L.; Cianferani, S.; Strub, J.-M.; Benard, M.; Flon, V.; Peulon-Agasse, V.; Cardinael, P.; Ory, S.; Gasman, S.; Renard, P.-Y.; Montero-Hadjadje, M.; Vitale, N.; Balieu, S.
10.1101/2025.02.20.639292 — neuroscience — Posted on 2025-02-25
843 Efficient Prospective Electric Field-Informed Localization of Motor Cortical Targets of Transcranial Magnetic Stimulation
Schultheiss, D. L.; Turi, Z.; Marmavula, S.; Reinacher, P. C.; Demerath, T.; Straehle, J.; Boedecker, J.; Mittner, M.; Vlachos, A.
10.1101/2025.02.20.639076 — neuroscience — Posted on 2025-02-25
844 The 16p11.2 microdeletion influences how early-life microbiota perturbations affect hippocampal development and behavior throughout the lifespan
McDermott, C. R.; Gao, Z.; Mirmajlesi, A. S.; Ntim, C.; Kimbark, K.; Thomas, D.; Mughal, Z.; Zhang, X.-S.; Zhou, X.; Popov, D.; Halchenko, A.; Xing, J.; Thakker-Varia, S.; Alder, J.; Millonig, J. H.; Samuels, B. A.; Blaser, M. J.; DiCicco-Bloom, E.
10.1101/2025.02.25.639888 — neuroscience — Posted on 2025-02-25
848 Experimental evidence of stress-induced critical state in schooling fish
Lin, G.; Escobedo, R.; Li, X.; Xue, T.; Han, Z.; Sire, C.; Guttal, V.; Theraulaz, G.
10.1101/2025.02.21.639527 — animal behavior and cognition — Posted on 2025-02-25
850 Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia
Alqahtani, A.; Eley, L.; Newton, J.; Macdonald, K.; Connolly, C.; Rodrigues-Cleto, C.; Neffeova, K.; Lopez, L.; Arias, J.; Derrick, C. J.; Alaradi, M.; Kolesova, H.; Chaudhry, B.; Henderson, D. J.
10.1101/2025.02.25.636485 — developmental biology — Posted on 2025-02-25
851 Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells
Rainey, R. N.; Houman, S. D.; Menendez, L.; Chang, R.; Tao, L.; Bugacov, H.; McMahon, A. P.; Kalluri, R.; Oghalai, J. S.; Groves, A. K.; Segil, N.
10.1101/2025.02.20.639352 — developmental biology — Posted on 2025-02-25
852 Single-Cell Roadmap of Early Hemato-Endothelial Development: Functions of Atf3, Zfp711 and Bcl6b
Cetin, R.; Picco, G.; Staalduinen, J. v.; Bindels, E.; Hoogenboezem, R.; Beek, G. v.; Sanders, M. A.; Fidan, Y.; Korkmaz, A.; Gribnau, J.; Haren, J. v.; Huylebroeck, D.; Mulugeta, E.; Grosveld, F.
10.1101/2025.02.23.639715 — developmental biology — Posted on 2025-02-25
855 Perinatal Nicotine Exposure Disrupts Hematopoietic Stem Cell Development and Elevates Influenza Susceptibility in Adulthood
Cool, T.; Rodriguez y Baena, A.; Rommel, M.; Mattingly, C.; Bachinsky, E.; Saini, S.; Chattopadhyaya, S.; Manso, B. A.; Rajendiran, S.; Worthington, A.; Poscablo, D.; Deguzman, A.; Berger-Cahn, T.; Boyd, D. F.; Forsberg, C.
10.1101/2025.02.23.639728 — developmental biology — Posted on 2025-02-25
856 Context-dependent response of endothelial cells to PIK3CA mutation
Sabata, H.; Roca-Coll, A.; Dengra, J. A.; Gouveia, L.; Martinez-Larrinaga, A.; Collado-Remacha, A.; Castillo, S. D.; Castillo, E.; Tisch, N.; De Andres-Laguillo, M.; Nornes, S.; Llena, J.; Villacampa, P.; Vanhaesebroeck, B.; Alcolea, M.; De Val, S.; Lopez-Fernandez, S.; De Bock, K.; Baselga, E.; Benedito, R.; Angulo-Urarte, A.; Graupera, M.
10.1101/2025.02.25.640041 — developmental biology — Posted on 2025-02-25
864 Dopaminergic Modulation of Short-Term Associative Memory in Caenorhabditis elegans
McMillen, A.; Minervini, C.; Green, R.; Johnson, M. E.; Ansaar, R.; Chew, Y. L.
10.1101/2025.02.20.639379 — neuroscience — Posted on 2025-02-25
866 Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics
Smith, D. D.; Bartley, J. E.; Peraza, J. A.; Bottenhorn, K. L.; Nomi, J.; Uddin, L. Q.; Riedel, M. C.; Salo, T.; Laird, R. W.; Pruden, S. M.; Sutherland, M.; Brewe, E.; Laird, A. R.
10.1101/2025.02.22.639361 — neuroscience — Posted on 2025-02-25
868 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum
Chan, J. C.; Di Salvo, G.; Cunningham, A. M.; Dutta, S.; Brindley, E. A.; Wan, E.; Zhang, C.; Maze, I.
10.1101/2025.02.20.639313 — neuroscience — Posted on 2025-02-25
869 β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity
Holmes, B. B.; Weigel, T. K.; Chung, J. M.; Kaufman, S. K.; Apresa, B. I.; Byrnes, J. R.; Kumru, K. S.; Vaquer-Alicea, J.; Gupta, A.; Rose, I. V.; Zhang, Y.; Nana, A. L.; Alter, D.; Grinberg, L. T.; Spina, S.; Leung, K. K.; Condello, C.; Kampmann, M.; Seeley, W. W.; Coutinho-Budd, J. C.; Wells, J. A.
10.1101/2025.02.20.637701 — neuroscience — Posted on 2025-02-25
873 Decoding peripheral saccade targets from foveal retinotopic cortex
Kaemmer, L.; Kroell, L. M.; Knapen, T.; Rolfs, M.; Hebart, M. N.
10.1101/2025.02.20.639262 — neuroscience — Posted on 2025-02-25
875 Deep Learning to Predict Future Cognitive Decline: A Multimodal Approach Using Brain MRI and Clinical Data
Chattopadhyay, T.; Senthilkumar, P.; Ankarath, R. H.; Patterson, C.; Gleave, E. J.; Thomopoulos, S. I.; Huang, H.; Shen, L.; You, L.; Zhi, D.; Thompson, P. M.
10.1101/2025.02.21.639520 — neuroscience — Posted on 2025-02-25
876 Astrocytic MAOB-GABA axis as a molecular brake on repair following spinal cord injury
Lee, H. Y.; Lee, J. M.; Lee, H.-L.; Park, J.; An, H.; Park, E. K.; Hwang, S. Y.; Hwang, G. Y.; Kim, K. N.; Nam, M.-H.; Lee, S. E.; Kang, H.; Won, J.; Jang, B. K.; Lee, E. H.; Choi, S.; Park, M. G.; Kim, S. W.; Park, K. D.; Lee, S.; Lee, C. J.; Ha, Y.
10.1101/2025.02.25.637603 — neuroscience — Posted on 2025-02-25
880 Saccadic Suppression Enhances Saliency of Prey-Like Stimuli in the Optic Tectum
Soto, G.; Thomas, C.; Hladnik, T. C.; Dehmelt, F. A.; Hafed, Z. M.; Arrenberg, A. B.
10.1101/2025.02.21.639462 — neuroscience — Posted on 2025-02-25
882 Synthetic Diffusion Tensor Imaging Maps Generated by 2D and 3D Probabilistic Diffusion Models: Evaluation and Applications
Chattopadhyay, T.; Jagad, C.; Kush, R.; Desai, V. D.; Thomopoulos, S. I.; Villalon-Reina, J. E.; Ambite, J. L.; Ver Steeg, G.; Thompson, P. M.
10.1101/2025.02.21.639511 — neuroscience — Posted on 2025-02-25
883 Glucose-dependent metabolism of hippocampal primary neurons in response to chemically induced long-term potentiation
Pudelko-Malik, N.; Drulis-Fajdasz, D.; Fydryszewski, M.; Burgess, S.; Mlynarz, P.; Rakus, D.; Deja, S.
10.1101/2025.02.24.639988 — neuroscience — Posted on 2025-02-25
885 Caloric restriction worsens decision-making impairments and gut dysbiosis after brain injury in male rats
Speas, R. L.; McCloskey, J. E.; Bressler, N. M.; Frankot, M. A.; Gratzol, C.; Pechacek, K. M.; Martens, K. M.; Vonder Haar, C.
10.1101/2025.02.24.639886 — neuroscience — Posted on 2025-02-25
887 Efficient elastic tissue motions indicate general motor skill
Namburi, P.; Pallares-Lopez, R.; Folgado, D.; Magana-Salgado, U.; Ryu, E.; Kappacher, A.; Gamboa, H.; Anthony, B. W.; Daniel, L.
10.1101/2025.02.25.636457 — animal behavior and cognition — Posted on 2025-02-25
890 Early onset memory deficit of WMI rats compared to their nearly isogenic WLIs is reversed by enriched environment in females
Ji, M. T.; Przybyl, K. J.; Harter, A. M.; Nemesh, M.; Jenz, S.; Yamazaki, A.; Kim, C.; Mulligan, M. K.; Chen, H.; Redei, E. E.
10.1101/2025.02.20.639157 — animal behavior and cognition — Posted on 2025-02-25
894 Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
Marteau, V.; Nemati, N.; Handler, K.; Raju, D.; Kvalem Soto, E.; Fotakis, G.; Carollo, S.; Boeck, N.; Rossi, A.; Kirchmair, A.; Scheiber, A.; Ammann, A.; Seeber, A.; Gasser, E.; Ormanns, S.; Guenther, M.; Martowicz, A.; Loncova, Z.; Lamberti, G.; Eling, M.; Horvath, L.; Krogsdam, A.; Carlet, M.; Fazilaty, H.; Valenta, T.; Sturm, G.; Rieder, D.; Sopper, S.; Pircher, A.; Stoitzner, P.; May, P. J.; Welker, P.; Wild, P. J.; Ziegler, P.; Tschurtschenthaler, M.; Huemer, F.; Neureiter, D.; Greil, R.; Weiss, L.; Ijsselsteijn, M.; de Miranda, N. F. C. C.; Wolf, D.; Arnold, I. C.; Salcher, S.; Trajanosk
10.1101/2024.08.26.609563 — bioinformatics — Posted on 2025-02-25
895 Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice
Kremer, L. S.; Gao, G.; Rigoni, G.; Filograna, R.; Mennuni, M.; Wibom, R.; Vegvari, A.; Koolmeister, C.; Larsson, N.-G.
10.1101/2024.11.14.623694 — genetics — Posted on 2025-02-25
897 On the quest for novelty in ecology
Ottaviani, G.; Martinez, A.; Petit Bon, M.; Mammola, S.
10.1101/2023.02.27.530333 — ecology — Posted on 2025-02-25
900 Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability
Curry, R. N.; McDonald, M. F.; He, P.; Lozzi, B.; Ko, Y.; O'Reilly, I.; Rosenbaum, A.; Kwon, W.; Fahim, L.; Marcus, J.; Powell, N.; Wang, S.; Ma, J.; Multani, A.; Choi, D.-J.; Sardar, D.; Mohila, C.; Lee, J.; Gallo, M.; Harmanci, A.; Harmanci, A. S.; Deneen, B.; Rao, G.
10.1101/2025.02.20.639365 — cancer biology — Posted on 2025-02-25
902 sRNA-mediated crosstalk between cell wall stress and galactose metabolism in Staphylococcus aureus
Germain, M.; Robin, H.; Le Huyen, K. B.; Massier, S.; Nalpas, N.; Hardouin, J.; Bouloc, P.; Rouillon, A.; Chabelskaya, S.
10.1101/2024.11.18.624069 — microbiology — Posted on 2025-02-25
905 Deep Learning based deconvolution methods: a systematic review
Lomas Redondo, A.; Sanchez Velazquez, J. M.; Garcia Tejedor, A. J.; Sanchez-Arevalo Lobo, V. J.
10.1101/2025.02.18.638595 — bioinformatics — Posted on 2025-02-25
908 GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research
Ingle, O. K.; Melville, L.; Beechener, S.; Hardy, C.; Howell, A.; Hobbs, N. P.; Mahon, N.; Morgan, E. R.; Bartley, D.; Rose Vineer, H.
10.1101/2025.02.21.639461 — ecology — Posted on 2025-02-25
909 Excavating Podocyte-Protective Targets of phloroglucinol-terpene hybrids Utilizing AI Models and Omics Analysis
Chen, T.; Liu, X.; Zhu, J.; Zhang, X.; Zhang, J.; Yu, H.; Xu, Z.; Wang, D.; Zhu, Y.; Zhong, F.; Luo, J.
10.1101/2025.02.22.639610 — cell biology — Posted on 2025-02-25
915 The genetic basis for synchronized time perception in plant populations
Lock, S. C. L.; McCarthy, K.; Ronald, J.; Anwer, M. U.; Davis, A.; Hallstein, M.; Redmond, E. J.; Knight, M.; Davis, S.; Ezer, D.
10.1101/2025.02.25.640030 — plant biology — Posted on 2025-02-25
920 Hypoxia-activated fluorescent probes as markers of oxygen levels in plant cells and tissues
Perri, M.; Khan, M. S.; Wallabregue, A. L. D.; Voloboeva, V.; Ridgway, A. M.; Smith, E. N.; Bolland, H.; Hammond, E. M.; Conway, S. J.; Weits, D. A.; Flashman, E.
10.1101/2025.02.20.639250 — plant biology — Posted on 2025-02-25
923 NtLLG4-mediated unconventional polar exocytosis of NtPPME1 coordinates cell wall rigidity and membrane dynamics to control pollen tube integrity
Weng, X.; Wang, H.; Jiang, Y.; Wang, Z.; Liu, C.; Chen, Z.; Yang, Z.; Gao, J.; Jiang, L.; Zhao, L.; Huang, J.; WANG, H.
10.1101/2025.02.24.639816 — plant biology — Posted on 2025-02-25
926 Exploring intra-specific variation in photosynthesis of maize and sorghum
Almeida, R. L.; Silveira, N. M.; Sartori, H. L.; Carvalho, C. C.; Scarpari, M. S.; Duarte, A. P.; Sawazaki, E.; Machado, E. C.; Ribeiro, R. V.
10.1101/2025.02.21.639328 — plant biology — Posted on 2025-02-25
927 Triphenylphosphonium is an effective targeting moiety for plants mitochondria
Lazary, S.; Mamam, G.; Binenbaum, J.; Ronen, M. M.; Tal, I.; Yariv, E.; Shani, E.; Weinstain, R.
10.1101/2025.02.20.638842 — plant biology — Posted on 2025-02-25
929 Pattern-triggered immunity in blue and white seed cultivars of Papaver somniferum
Hernandez Orozco, J. S.; Iakovenko, O.; Zeiner, A.; Hronkova, M.; Kubasek, J.; Kucerova, B.; Vachova, I.; Pop, S.; Marsik, P.; Macho, M.; Fojtikova, P.; Rychla, A.; Hejna, O.; Kulich, I.; Wrzaczek, M.; Janda, M.
10.1101/2025.02.23.639761 — plant biology — Posted on 2025-02-25
932 Stress drives plasticity in leaf maturation transcriptional dynamics
Swift, J.; Wu, X.; Xu, J.; Jain, T.; Illouz-Eliaz, N.; Nery, J. R.; Chory, J.; Ecker, J. R.
10.1101/2025.02.24.639183 — plant biology — Posted on 2025-02-25
933 Cryptic variation fuels plant phenotypic change through hierarchical epistasis
Zebell, S. G.; Martl-Gomez, C.; Fitzgerald, B.; Pinto Da Cunha, C.; Lach, M.; Seman, B. M.; Hendelman, A.; Sretenovic, S.; Qi, Y.; Eshed, Y.; McCandlish, D. M.; Lippman, Z.
10.1101/2025.02.23.639722 — plant biology — Posted on 2025-02-25
934 A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy
Liu, R.; Weng, X.; Li, X.; Cao, Y.; Li, Q.; Luan, L.; Tong, D.; Kong, Z.; Wang, H.; Wang, T.; Gong, Q.
10.1101/2025.02.21.639444 — plant biology — Posted on 2025-02-25
935 Atypical endo-β-1,4-mannannases are necessary for normal glucomannan synthesis in Arabidopsis
Kikuchi, A.; Sato, E.; Yoshimi, Y.; Takasaki, H.; Nishigaki, N.; Atsuzawa, K.; Kaneko, Y.; Yamaguchi, M.; Takahashi, D.; Dupree, P.; Kotake, T.
10.1101/2025.02.21.639209 — plant biology — Posted on 2025-02-25
936 A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs
Pai, H.; Sakai, T.; Posbeyikian, A.; Frijters, R.; Sugihara, Y.; Contreras, M. P.; Kourelis, J.; Adachi, H.; Kamoun, S.; Toghani, A.
10.1101/2025.02.25.639832 — plant biology — Posted on 2025-02-25
938 Spatial transcriptomic profiling reveals distinct signatures in acute versus chronic wounds through hypergraph modelling and transcriptomic entropy analysis.
Sharps, M. C.; Herrera, J. A.; Moscalu, R.; Wright, L. I.; Garner, T.; Murtuza Baker, S.; Reid, A.; Stevens, A.; Wong, J. K. F.
10.1101/2025.02.21.639341 — physiology — Posted on 2025-02-24
940 Neoplastic immune mimicry potentiates breast tumor progression
Berens, E. B.; Khou, S.; Huang, E.; Hoffman, A.; Johnson, B.; Kirchberger, N.; Sivagnanam, S.; Calistri, N. L.; Derrick, D.; Liby, T. A.; McLean, I. C.; Alanizi, A. A.; Ozmen, F.; Ozmen, T. Y.; Mills, G. B.; Hwang, E. S.; Schedin, P. J.; Gonzalez, H.; Werb, Z.; Heiser, L. M.; Coussens, L. M.
10.1101/2025.01.17.633673 — cancer biology — Posted on 2025-02-25
941 Identification of targetable epigenetic vulnerabilities for uveal melanoma
Yenisehirli, G.; Borges, S.; Braun, S. S.; Zuniga, A. N.; Quintana, G. I.; Kuznetsoff, J. N.; Rodriguez, S.; Adis, E. V.; Lopez, S.; Dollar, J. J.; Stathias, V.; Volmar, C. H.; Karaca, E.; Brothers, S.; Bilbao, D.; Harbour, J. W.; Correa, Z. M.; Kurtenbach, S.
10.1101/2024.10.11.617464 — cancer biology — Posted on 2025-02-25
942 AMPK- and cGAS-Mediated Dual Sensing of Glucose and dsDNA Synergizes to Enhance Antitumor Immunity
Zhou, R.; Pei, J.; Chen, S.; Shen, Q.; Wu, Q.; Liu, S.; Feng, X.-H.; Zou, J.; Liang, T.; Zhang, Y. J.; Lin, S.-C.; Song, P.; Zhang, C.-S.; Zhang, Q.; Xu, P.
10.1101/2025.02.15.638470 — cancer biology — Posted on 2025-02-25
943 Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging
Xiao, Y.; Elmasry, M.; Bai, J.; Chen, A.; Chen, Y.; Jackson, B.; Johnson, J. O.; Gillies, R. J.; Prasanna, P.; Chen, C.; Damaghi, M.
10.1101/2024.06.23.600274 — cancer biology — Posted on 2025-02-25
944 Filament transport supports contractile steady states of actin networks.
Sciortino, A.; Orhant-Prioux, M.; Guerin, C.; Bonnemay, L.; Takagi, Y.; Sellers, J. R.; Colin, A.; Thery, M.; Blanchoin, L.
10.1101/2025.02.21.639071 — biophysics — Posted on 2025-02-25
951 Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition
Gaurav, K.; Busetto, V.; Moscoso, D. J. P.; Changiarath, A.; Hanson, S. M.; Falk, S.; Ketting, R. F.; Stelzl, L. S.
10.1101/2024.04.13.589337 — bioinformatics — Posted on 2025-02-25
955 Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins
May, A. J.; Lella, M.; Lindenberger, J.; Berkman, A.; Kumar, U.; Dutta, M.; Barr, M.; Parks, R.; Newman, A.; Huang, X.; Song, K.; Ilevbare, V.; Sammour, S.; Park, C. S.; Adhikari, R. D.; Devkota, P.; Janowska, K.; Liu, Y.; Scapellato, G.; Spence, T. N.; Mansouri, K.; Edwards, R. J.; Saunders, K. O.; Haynes, B. F.; Acharya, P.
10.1101/2024.12.11.627382 — biochemistry — Posted on 2025-02-25
958 The Multiomics Blueprint of Extreme Human Lifespan
Santos-Pujol, E.; Noguera-Castells, A.; Casado-Pelaez, M.; Garcia-Prieto, C. A.; Vasallo, C.; Campillo-Marcos, I.; Quero-Dotor, C.; Crespo-Garcia, E.; Bueno-Costa, A.; Setien, F.; Ferrer, G.; Davalos, V.; Mereu, E.; Pluvinet, R.; Arribas, C.; de la Torre, C.; Villavicencio, F.; Sumoy, L.; Granada, I.; Coles, N. S.; Acha, P.; Sole, F.; Mallo, M.; Mata, C.; Peregrina, S.; Gabaldon, T.; Lliros, M.; Pujolassos, M.; Carreras-Torres, R.; Lluansi, A.; Garcia-Gil, L. J.; Aldeguer, X.; Samino, S.; Torne, P.; Ribalta, J.; Guardiola, M.; Amigo, N.; Yanes, O.; Martinez, P.; Sanchez-Vazquez, R.; Blasco, M.
10.1101/2025.02.24.639740 — genomics — Posted on 2025-02-25
960 Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery
Tastemel, M.; Jussila, A. P.; Saravanan, B.; Huang, H.; Xie, Y.; Zhu, Q.; Jiang, Y.; Armand, E.; Ren, B.
10.1101/2025.02.21.639596 — genomics — Posted on 2025-02-25
961 Trait-environment interactions influence tree planting success in Peruvian tropical dry forests
Goossens, W.; Fremout, T.; Muys, B.; Soto Quispe, J. C.; Van Meerbeek, K.; Maes, S. L.
10.1101/2025.02.21.639418 — ecology — Posted on 2025-02-25
964 Myelin transcription factors 1 and 3 have overlapping but distinct roles in insulin secretion and survival of human β cells
Hu, R.; Yagan, M.; Wang, Y.; Tong, X.; Doss, T.; Liu, J.-H.; Xu, Y.; Simmons, A.; Lau, K.; stein, r.; Liu, Q.; Gu, G.
10.1101/2025.02.24.639737 — cell biology — Posted on 2025-02-25
969 Lamin B loss in nuclear blebs is rupture dependent while increased DNA damage is rupture independent
Chu, C. G.; Lang, N.; Walsh, E.; Zheng, M. D.; Manning, G.; Shalin, K.; Cunha, L. M.; Faucon, K. E.; Kam, N.; Folan, S. N.; Desai, A. P.; Naughton, E.; Abreu, J.; Carson, A. M.; Wald, Z. L.; Khvorova-Wolfson, D.; Phan, L.; Lee, H. H.; Pho, M.; Prince, K.; Dorfman, K.; Bahiru, M. S.; Stephens, A. D.
10.1101/2025.02.24.639904 — cell biology — Posted on 2025-02-25
970 Genetically encoded reporters of actin filament organization in living cells and tissues
Silva Martins, C.; Iv, F.; Kumar Suman, S.; Panagiotou, T. C.; Sidor, C.; Ruso-Lopez, M.; Plancke, C. N.; Omi, S.; Pages, R.; Gomes, M.; Llewellyn, A.; Bandi, S. R.; Ramond, L.; Arbizzani, F.; Rimoli, C. V.; Schnorrer, F.; Robin, F.; Wilde, A.; LeGoff, L.; Pedelacq, J.-D.; Jegou, A.; Cabantous, S.; Rincon, S. A.; Chandre, C.; Brasselet, S.; Mavrakis, M.
10.1101/2024.04.26.591305 — cell biology — Posted on 2025-02-25
972 Activation and Evasion of the FEAR Pathway by RNA Viruses
Rex, E. A.; Seo, D.; Embry, A.; Arulanandam, R.; Spinelli, M. M.; Diallo, J.-S.; Gammon, D. B.
10.1101/2024.08.22.609092 — microbiology — Posted on 2025-02-25
973 Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish infection
Gifford, H.; Bedekovic, T.; Helmstetter, N.; Gregory, J.; Ma, Q.; Brand, A. C.; Wilson, D.; Rhodes, J.; Ramsdale, M.; Kudoh, T.; Farrer, R. A.
10.1101/2024.10.22.619744 — microbiology — Posted on 2025-02-25
974 Enhanced Working Memory Representations for Rare Events
Carrasco, C. D.; Simmons, A. M.; Kiat, J. E.; Luck, S. J.
10.1101/2024.03.20.585952 — neuroscience — Posted on 2025-02-25
976 hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cells
Cardozo, P. L.; Lee, C.-Y.; Lacerda, J. P. S.; Fahel, J. S.; Trindade, P.; Vitoria, G.; Chicaybam, L.; Cordeiro, R. C.; de Faria, I. J. S.; Silva, N. C.; Todjro, Y. M. H.; Maciel, J. C. d. P.; Bonamino, M. H.; Vieira, L. B.; Cruz, B. F.; Nicolato, R.; Brennand, K. J.; Rehen, S. K.; Ribeiro, F. M.
10.1101/2024.09.20.614161 — neuroscience — Posted on 2025-02-25
977 Octopamine signals coordinate the spatial pattern of presynaptic machineries within individual Drosophila mushroom body neurons
Wu, H.; Eno, S.; Jinnai, K.; Maekawa, Y.; Saito, K.; Abe, A.; Williams, D. W.; Yamagata, N.; Kondo, S.; Tanimoto, H.
10.1101/2024.12.02.626512 — neuroscience — Posted on 2025-02-25
979 Thalamic Influence Over Adaptive Cortical Dynamics Across Conscious States
Muller, E. J.; Munn, B.; Baracchini, G.; Fulcher, B. D.; Medel, V.; Redinbaugh, M. J.; Saalmann, Y. B.; Brunton, B. W.; Brunton, S. L.; Shine, J.
10.1101/2024.07.02.601788 — neuroscience — Posted on 2025-02-25
980 Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations
Hawkes, G.; Wright, H. I. W.; Beaumont, R. N.; Chundru, K.; Hanson, A.; Jackson, L.; Murray, A. N.; Patel, K.; Frayling, T.; Wright, C.; Wood, A. R.; Weedon, M. N.
10.1101/2025.02.24.639925 — genetics — Posted on 2025-02-25
981 Identification of functional non-coding variants associated with orofacial cleft
Kumari, P.; Friedman, R. Z.; Pi, L.; Curtis, S. W.; Paraiso, K.; Visel, A.; Rhea, L.; Dunnwald, M.; Patni, A. P.; Mar, D.; Bomsztyk, K.; Mathieu, J.; Ruohola-Baker, H.; Leslie, E. J.; White, M. A.; Cohen, B. A.; Cornell, R. A.
10.1101/2024.06.01.596914 — genetics — Posted on 2025-02-25
983 It is hard to be small: Inbreeding depression depends on the body size in a threatened songbird
Kubacka, J.; Arantes, L. S.; Herdegen-Radwan, M.; Osiejuk, T. S.; Sparmann, S.; Mazzoni, C. J.
10.1101/2024.04.21.590470 — evolutionary biology — Posted on 2025-02-25
985 Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons
Stocksdale, J. T.; Leventhal, M. J.; Lam, S.; Xu, Y.-X.; Wang, Y. O.; Wang, K. Q.; Tomas, R.; Faghihmonzavi, Z.; Raghav, Y.; Smith, C.; Wu, J.; Miramontes, R.; Sarda, K.; Johnson, H.; Shin, M.-G.; Huang, T.; Foster, M.; Barch, M.; Armani, N.; Paiz, C.; Easter, L.; Duderstadt, E.; Vaibhav, V.; Sundararaman, N.; Felsenfeld, D. P.; Vogt, T. F.; Van Eyk, J.; Finkbeiner, S.; Kaye, J. A.; Fraenkel, E.; Thompson, L. M.
10.1101/2025.02.24.639958 — cell biology — Posted on 2025-02-25
986 Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy
Schwenzer, N.; Tsukanov, R.; Kohl, T.; Basak, S.; Sobitov, I.; Seibertz, F.; Kapoor, R.; Voigt, N.; Enderlein, J.; Lehnart, S. E.
10.1101/2024.02.26.582084 — cell biology — Posted on 2025-02-25
987 Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival
Goswami, M. T.; Weh, E.; Subramanya, S.; Weh, K. M.; Durumutla, H. B.; Hager, H.; Miller, N.; Chaudhury, S.; Andren, A.; Sajjakulnukit, P.; Zhang, L.; Besirli, C. G.; Lyssiotis, C. A.; Wubben, T. J.
10.1101/2024.03.26.582525 — cell biology — Posted on 2025-02-25
988 Scalable emulation of protein equilibrium ensembles with generative deep learning
Lewis, S.; Hempel, T.; Jimenez Luna, J.; Gastegger, M.; Xie, Y.; Foong, A. Y. K.; Garcia Satorras, V.; Abdin, O.; Veeling, B. S.; Zaporozhets, I.; Chen, Y.; Yang, S.; Schneuing, A.; Nigam, J.; Barbero, F.; Stimper, V.; Campbell, A.; Yim, J.; Lienen, M.; Shi, Y.; Zheng, S.; Schulz, H.; Munir, U.; Tomioka, R.; Clementi, C.; Noe, F.
10.1101/2024.12.05.626885 — molecular biology — Posted on 2025-02-25
989 In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
Capoferri, A. A.; Sklutuis, R.; Famuyiwa, T. O.; Pathak, S.; Li, R.; Rausch, J. W.; Luke, B. T.; Hoh, R.; Deeks, S. G.; Mellors, J. W.; Coffin, J. M.; Groebner, J. L.; Romerio, F.; Kearney, M. F.
10.1101/2024.12.06.627170 — microbiology — Posted on 2025-02-25
991 Revealing the diversity of commensal corynebacteria from a single human skin site
Herman, R.; Meaden, S.; Rudden, M.; Cornmell, R.; Wilkinson, H. N.; Hardman, M. J.; Wilkinson, A. J.; Murphy, B.; Thomas, G. H.
10.1101/2024.11.28.625817 — microbiology — Posted on 2025-02-25
992 A variational deep-learning approach to modeling memory T cell dynamics
van Dorp, C. H.; Gray, J. I.; Paik, D. H.; Farber, D. L.; Yates, A. J.
10.1101/2024.07.08.602409 — immunology — Posted on 2025-02-25
995 Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Fan, X.-R.; He, Y.; Wang, Y.-S.; Li, L.; Lifespan Brain Chart Consortium (LBCC), ; China Autism Brain Imaging Consortium (CABIC), ; Duan, X.; Zuo, X.-N.
10.1101/2025.02.24.639771 — neuroscience — Posted on 2025-02-25
997 The pulvinar regulates plasticity in human visual cortex
Acquafredda, M.; Kurzawski, J. W.; Biagi, L.; Tosetti, M.; Morrone, M. C.; Binda, P.
10.1101/2025.02.24.639829 — neuroscience — Posted on 2025-02-25
998 Neurometabolic signaling and control of policy complexity
Tesmer, A. L.; Pola, C. D.; Gilli, D.; Grujic, N.; Bracey, E.; Patriarchi, T.; Peleg-Raibstein, D.; Polania, R.; Burdakov, D.
10.1101/2025.02.24.639890 — neuroscience — Posted on 2025-02-25
1002 Pathological tau alters head direction signaling and induces spatial disorientation
Jiang, S.; Hijazi, S.; Sarkany, B.; Gautsch, V. G.; Lachance, P. A.; Hasselmo, M. E.; Bannerman, D.; Viney, T. J.
10.1101/2024.11.07.622548 — neuroscience — Posted on 2025-02-25
1004 Food intake enhances hippocampal sharp wave-ripples
Kaya, E.; Wegienka, E.; Akhtarzandi-Das, A.; Do, H.; Eban-Rothschild, A.; Rothschild, G.
10.1101/2024.10.08.617304 — neuroscience — Posted on 2025-02-25
1008 The pioneer transcription factor ELF2 remodels the nucleosome near transcription start sites
Xiao, T.; Crowe-McAuliffe, C.; Ochmann, M.; Du, Y.; Hou, T.; Chen, Y.; Zhu, F.; Seyednasrollah, F.; Osmala, M.; Vanharanta, S.; Morgunova, E.; Cramer, P.; Rogerson, C.; Dienemann, C.; Taipale, J.
10.1101/2024.05.24.595749 — biochemistry — Posted on 2025-02-25
1010 Canonical Hedgehog Signaling Controls Astral Microtubules and Mitotic Spindle Orientation in Neural Progenitors and iPSCs
Liu, F.; Medyukhina, A.; Olesen, K. M.; Shirinifard, A.; Jin, H.; Li, L.; Mapelli, M.; Khairy, K.; Han, Y.-G.
10.1101/2025.02.23.639780 — developmental biology — Posted on 2025-02-25
1014 De novo biosynthesis of cannabinoid and its analogs in Yarrowia lipolytica
Hong, Y.; Gu, Y.; Lin, D.; Wu, Z.; Chen, W.; Lu, T.; Lertphadungkit, P.; Ma, J.; Wang, H.; Zhou, B.; Bar-Sela, G.; Cohen, I.; Xu, P.
10.1101/2025.02.23.639773 — synthetic biology — Posted on 2025-02-24
1017 Sex-dependent effects of a gestational ketogenic diet on offspring birth and lifespan
Zala, S. M.; Santos, R.; Strauss, E.; Schadde, A.; Kugler, S.; Strauss, V.; Kuebber-Heiss, A.; Zala, D.
10.1101/2025.02.19.639045 — physiology — Posted on 2025-02-24
1018 Alternative splicing broadens antiviral diversity at the human OAS2 locus
Davies, E. L.; Sowar, H.; Balci, A.; Moorhouse, E.; Wickenhagen, A.; Turnbull, M. L.; Palmarini, M.; Wilson, S. J.; Fletcher, A. J.
10.1101/2025.02.24.639105 — microbiology — Posted on 2025-02-24
1020 NRF2 activators restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1
Waqas, F. H.; Zapatero-Belinchon, F. J.; Carter-Timofte, M. E.; Lasswitz, L.; van der Horst, D.; Möller, R.; Dahlmann, J.; Olmer, R.; Geffers, R.; Gerold, G.; Olagnier, D.; Pessler, F.
10.1101/2025.02.24.639813 — pharmacology and toxicology — Posted on 2025-02-24
1022 3D Bioprinted Cell-laden GrooveNeuroTube: A Multifunctional Platform for Ex Vivo Neural Cell Migration and Growth Studies
Litowczenko, J.; Richter, Y.; Indurkar, A.; Tadyszak, K.; Ostrowski, A.; Popenda, L.; Fiedorowicz, K.; Cabello, J. C. R.; Wychowaniec, J. K.
10.1101/2025.02.19.639097 — bioengineering — Posted on 2025-02-24
1023 Phospholipid esters from herring roe promotes SPM biosynthesis in human monocyte-derived macrophages and a keratinocyte/fibroblast co-culture with implications for the treatment of psoriasis
Ringheim-Bakka, T. A.; Saliani, A.; Ostbye, T.-K. K.; Mildenberger, J.; Dooley, M.; Busygina, M.; Pedersen, M. E.; Solberg, N. T.; Dalli, J.; Gammelsaeter, R.
10.1101/2025.02.20.639253 — biochemistry — Posted on 2025-02-24
1026 Deciphering the dynamics of Cyanobacteria-Phage in a natural lake: Insights from a decade-long investigation
Stern, K.; Vincent, J.; Taranu, Z. E.; Fortin, N.; Martel, A.; Robbe, A.; Thaize, R.; Castelli, M.; Beckett, S. J.; Poisot, T.; Buckling, A.; Shapiro, B. J.; Tromas, N.
10.1101/2025.02.19.639072 — ecology — Posted on 2025-02-24
1027 PARP inhibitors affect the replisome and replication fork progression during a single S phase.
Briu, L.-M.; Maric, C.; Valentin, N.; Panara, N.; Chevreux, G.; Baldacci, G.; Cadoret, J.-C.
10.1101/2025.02.20.639283 — molecular biology — Posted on 2025-02-24
1028 The Orai channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry
Hyser, J. M.; Scribano, F. J.; Gebert, J. T.; Engevik, K. A.; Hayes, N. M.; Pham, S.; Kaundal, S.; Dave, J.; Prasad, B. V. V.; Estes, M. K.; Ramani, S.
10.1101/2025.02.23.639787 — microbiology — Posted on 2025-02-24
1030 Linear dicentric chromosomes in bacterial natural isolates reveal common constraints for replicon fusion
Sanath-Kumar, R.; Rahman, A.; Ren, Z.; Reynolds, I. P.; Augusta, L.; Fuqua, C.; Weisberg, A. J.; Wang, X.
10.1101/2025.02.23.639760 — microbiology — Posted on 2025-02-24
1031 An Experimental and Multiphysics Simulations Study of Clostridium carboxidivorans sp. 624 for Acid and Alcohol Production in CO2/H2
Tiong, Y. W.; Yong, A.; Nalaparaju, A.; Nguyen, H.-H.; Koh, L. Q.; Wong, R. J.; Lim, R. T. Y.; Ow, D. S.-W.; Zhang, J.; Nguyen, V. B.; Wong, F. T.; Lim, Y. H.
10.1101/2025.02.24.639814 — microbiology — Posted on 2025-02-24
1034 Ketogenic Diet Enhances Cognitive-Behavioral Function and Hippocampal Neurogenesis While Attenuating Amyloid Pathology in Tg-SwDI Mice
Pulido-Correa, V. E.; Hernandez, A.; Wind, E. J.; Zhu, Y.; Vogel, C.; Binu, S.; Jeneske, M.; Kuni, D.; Chiduruppa, V.; Echeverria, B.; Rosenberg, L.; Robison, L. S.
10.1101/2025.02.19.639138 — neuroscience — Posted on 2025-02-24
1038 Additive manufacturing of patient-specific intracranial aneurysm cell culture models
De Nys, C.; Murphy, A. R.; Wood, J.-L.; Novak, J. I.; Carluccio, D.; Winter, C. D.; Allenby, M. C.
10.1101/2025.02.24.639980 — bioengineering — Posted on 2025-02-24
1039 Protective antigen-mediated delivery of an anti-CRISPR proteinfor precision genome editing
Vera, A. O.; Truex, N. L.; Sreekanth, V.; Pentelute, B. L.; Choudhary, A.; Raines, R. T.
10.1101/2025.02.23.639680 — biochemistry — Posted on 2025-02-24
1040 Consequences of training data composition for deep learning models in single-cell biology
Nadig, A.; Thoutam, A.; Hughes, M.; Gupta, A.; Navia, A. W.; Fusi, N.; Raghavan, S.; Winter, P. S.; Amini, A. P.; Crawford, L.
10.1101/2025.02.19.639127 — genomics — Posted on 2025-02-24
1041 Resource economics of tree communities control soil food web multifunctionality in European forests
Henneron, L.; Wardle, D. A.; Berg, M. P.; Hattenschwiler, S.; Bauhus, J.; Buscot, F.; Coq, S.; Decaens, T.; Fromin, N.; Ganault, P.; Gillespie, L. M.; Goldmann, K.; Matula, R.; Milcu, A.; Muys, B.; Nahmani, J.; Prada-Salcedo, L. D.; Scherer-Lorenzen, M.; Verheyen, K.; Wambsganss, J.; Kardol, P.
10.1101/2025.02.19.639063 — ecology — Posted on 2025-02-24
1042 Flagellin in the human gut microbiome is a diet-adjustable adjuvant for vaccination
Huus, K. E.; uHEAT Clinical Study Group, ; Tan, Y. H.; Abo, H.; Keller, R.; Atay, E.; Vu, D. L.; Dauser, S.; Prokipchuk, A.; Tyakht, A.; Youngblut, N.; Chassaing, B.; Kang, S.-M.; Parsonnet, J.; Kremsner, P. G.; Maier, L.; Gewirtz, A. T.; Esen, M.; Ley, R. E.
10.1101/2025.02.21.639485 — microbiology — Posted on 2025-02-24
1044 Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 variants
Merkling, S. H.; Couderc, E.; Crist, A. B.; Dabo, S.; Daron, J.; Jupatanakul, N.; Burckbuchler, M.; Sismeiro, O.; Legendre, R.; Pain, A.; Varet, H.; Jiolle, D.; Ayala, D.; Paupy, C.; Marois, E.; Lambrechts, L.
10.1101/2025.02.24.639860 — microbiology — Posted on 2025-02-24
1051 Swiftly squeaky clean: lessons learned from eradicating an overpopulation of rats on an island of constraints
Micheletti, T.; Mello, T. J.; Verona, C.; Gasparotto, V. P. O.; Krul, R.; Araujo, R.; Sampaio, T.; Mangini, P. R.
10.1101/2025.02.19.639051 — ecology — Posted on 2025-02-24
1055 Fiber photometry analysis for spontaneous dopamine signals: The z-scored data are not the data
Wallace, C. W.; Slinkard, C. Y.; Shaughnessy, R.; Holleran, K. M.; Centanni, S. W.; Lapish, C. C.; Jones, S. R.
10.1101/2025.02.19.639080 — neuroscience — Posted on 2025-02-24
1057 Integrated Ultrasound Neuromodulation and Optical Neuroimaging in Awake Mice using a Transparent Ultrasound Transducer Cranial Window
Mirg, S.; Samanta, K.; Chen, H.; Jiang, J.; Turner, K. L.; Salehi, F.; Ramiah, K. M.; Drew, P. J.; Kothapalli, S.-R.
10.1101/2025.02.19.638722 — neuroscience — Posted on 2025-02-24
1058 RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation
Mayday, M. Y.; Biancon, G.; Wei, M.; Ramirez, C.; Moratti, I.; Pintado-Urbanc, A. P.; Wang, L.; Espinosa, J. A.; Simon, M. D.; Ofir-Rosenfeld, Y.; Rausch, O.; Tebaldi, T.; Halene, S.; Krause, D. S.
10.1101/2025.02.19.638991 — cancer biology — Posted on 2025-02-24
1059 Insights into the structure and modulation of human TWIK-2
Ma, Q.; Hernandez, C. Q.; Navratna, V.; Kumar, A.; Lee, A.; Mosalaganti, S.
10.1101/2025.02.19.639014 — biophysics — Posted on 2025-02-24
1062 Circularization of Single-Stranded DNA Donor Template Unleashes the Power of Non-Viral Gene Delivery for Long-Term HSCs editing
Letort, G.; Duclert, A.; Le Clerre, D.; Chion-Sotinel, I.; Salvatori, R.; Dessez, E.; Sevin, M.; Rotondi, M.; Ducani, C.; Duchateau, P.; Valton, J.
10.1101/2025.02.19.638978 — bioengineering — Posted on 2025-02-24
1063 Lab-in-the-loop therapeutic antibody design with deep learning
Frey, N. C.; Hotzel, I.; Stanton, S. D.; Kelly, R. L.; Alberstein, R. G.; Makowski, E. K.; Martinkus, K.; Berenberg, D.; Bevers, J.; Bryson, T.; Chan, P.; Czubaty, A.; D'Souza, T. A.; Dwyer, H.; Dziewulska, A.; Fairman, J. W.; Goodman, A.; Hofmann, J. L.; Isaacson, H. H.; Ismail, A. A.; James, S.; Joren, T.; Kelow, S. P.; Kiefer, J. R.; Kirchmeyer, M.; Kleinhenz, J.; Koerber, J. T.; Lafrance-Vanasse, J.; Leaver-Fay, A.; Lee, J. H.; Lee, E.; Lee, D. W.; Liang, W.-C.; Lin, J. Y.-Y.; Lisanza, S.; Loukas, A.; Ludwiczak, J.; Mahajan, S. P.; Mahmood, O.; MohammadiPeyhani, H.; Nerli, S.; Park, J. W.;
10.1101/2025.02.19.639050 — bioengineering — Posted on 2025-02-24
1065 Characterizing organisms from three domains of life with universal primers from throughout the global ocean
McNichol, J. C.; Williams, N. L.; Raut, Y.; Carlson, C. A.; Halewood, E. R.; Turk-Kubo, K. A.; Zehr, J. P.; Rees, A. P.; Tarran, G.; Gradoville, M. R.; Wietz, M.; Bienhold, C.; Metfies, K.; Torres-Valdes, S.; Mock, T.; Eggers, S. L.; Jeffrey, W.; Moss, J.; Berube, P. M.; Biller, S.; Bodrossy, L.; van de Kamp, J.; Brown, M. V.; Sow, S. L. S.; Armbrust, E. V.; Fuhrman, J.
10.1101/2025.02.19.638942 — ecology — Posted on 2025-02-24
1066 Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia
Ibrahim, M.; Gomez-Jenkins, M.; Scheinfeld, A.; Zhao, Z.; Lopes, E. C.; Sawant, A.; Hu, Z. S.; Dharani, A.; Sun, M.; Siddiqui, S.; Mirek, E. T.; Saliba, J. A.; Lattime, E.; Su, X.; Janowitz, T.; Goncalves, M.; Dunn, S.; Pritykin, Y.; Anthony, T.; Rabinowitz, J.; White, E.
10.1101/2025.02.20.638910 — molecular biology — Posted on 2025-02-24
1068 Brain-wide mapping reveals temporal and sexually dimorphic opioid actions
Vasylieva, I.; Smith, M. C.; Aravind, E.; He, K.; Ling, T.; Kozel, J.; Puig, S.; Kedziora, K. M.; Scarlett, J. J.; Joseph, P. N.; Lycas, M. D.; Gether, U.; Logan, R. W.; Freyberg, Z.; Watson, A. M.
10.1101/2025.02.19.638902 — neuroscience — Posted on 2025-02-24
1072 Detecting Primary Progressive Aphasia (PPA) from Text: A Benchmarking Study
Merhbene, G.; Lecron, F.; Fortemps, P.; Dickerson, B. C.; Kurpicz-Briki, M.; Rezaii, N.
10.1101/2025.02.19.639032 — neuroscience — Posted on 2025-02-24
1078 Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region
Ondrejcak, T.; Hu, N.-W.; Coode, E.; Campbell, T.; Corbett, G. T.; Doykov, I.; Mills, K.; Walsh, D. M.; Livesey, F. J.; Rowan, M. J.; Klyubin, I.
10.1101/2025.02.21.639417 — neuroscience — Posted on 2025-02-24
1080 Central amygdalar PKCδ neurons mediate fentanyl withdrawal
Wooldridge, L. M.; Wu, J. W. K.; Jo, A. Y.; Zinn, M.; Lee, A. M.; Mahmood, M.; Cohen, S. A.; Corder, G.
10.1101/2025.02.21.639538 — neuroscience — Posted on 2025-02-24
1081 An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster
Zung, J. L.; Namiki, S.; Meissner, G. W.; Costa, M.; Eichler, K.; Stürner, T.; Jefferis, G. S. X. E.; Managan, C.; FlyLight Project Team, ; Korff, W.; Card, G. M.
10.1101/2025.02.22.639679 — neuroscience — Posted on 2025-02-24
1089 Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology
Kokoris, M.; McRuer, R.; Nabavi, M.; Jacobs, A.; Prindle, M.; Cech, C.; Berg, K.; Lehmann, T.; Machacek, C.; Tabone, J.; Chandrasekar, J.; McGee, L.; Lopez, M.; Reid, T.; Williams, C.; Barrett, S.; Lehmann, A.; Kovarik, M.; Busam, R.; Miller, S.; Banasik, B.; Kesic, B.; Arryman, A.; Rogers-Peckham, M.; Kimura, A.; LeProwse, M.; Wolfin, M.; Kritzer, S.; Leadbetter, J.; Babazedeh, M.; Chase, J.; Thiessen, G.; Lint, W.; Goodman, D.; O'Connell, D.; Lumanpauw, N.; Hoffman, J.; Vellucci, S.; Collins, K.; Vellucci, J.; Taylor, A.; Murphy, M.; Lee, M.; Corning, M.
10.1101/2025.02.19.639056 — genomics — Posted on 2025-02-24
1092 3D spatial transcriptomics reveals the molecular domain structure of the mouse olfactory bulb
Klimpert, N.; Kollo, M.; Brann, D. H.; Tan, C.; Barry, D.; Ma, Y.; Schaefer, A. T.; Fleischmann, A.
10.1101/2025.02.19.639192 — neuroscience — Posted on 2025-02-24
1094 Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang, J.; Ubas, A. A.; de Borja, R.; Svensson, V.; Thomas, N.; Thakar, N.; Lai, I.; Winters, A.; Khan, U.; Jones, M. G.; Tran, V.; Pangallo, J.; Papalexi, E.; Sapre, A.; Nguyen, H.; Sanderson, O.; Nigos, M.; Kaplan, O.; Schroeder, S.; Hariadi, B.; Marrujo, S.; Salvino, C. C. A.; Gallareta Olivares, G.; Koehler, R.; Geiss, G.; Rosenberg, A.; Roco, C.; Merico, D.; Alidoust, N.; Goodarzi, H.; Yu, J.
10.1101/2025.02.20.639398 — genomics — Posted on 2025-02-24
1095 Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster
Ribeiro, T. d. S.; Lollar, M. J.; Sprengelmeyer, Q. D.; Huang, Y.; Benson, D. M.; Orr, M. S.; Johnson, Z. C.; Corbett-Detig, R. B.; Pool, J. E.
10.1101/2024.05.14.594228 — evolutionary biology — Posted on 2025-02-24
1098 Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution
Foster, C. S. P.; Walker, G. J.; Jean, T.; Wong, M.; Brassil, L.; Isaacs, S.; Lu, Y.; Turville, S. G.; Kelleher, A.; Rawlinson, W. D.
10.1101/2023.11.02.565396 — evolutionary biology — Posted on 2025-02-24
1099 Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex
Park, E.; Reilly, K. O.; Grubbs, G.; Taborga, D.; Nicholas, K.; Ahmeda, A. S.; Ruiz, N.; Kim, N.; Segura-Carrillo, S.; Fenton, A. A.
10.1101/2019.12.20.884262 — neuroscience — Posted on 2025-02-24
1101 Adaptations of gram-negative and gram-positive probiotic bacteria in engineered living materials
Tadimarri, V. S.; Tyagi, T. A.; Duong, C. N.; Rasheed, S.; Mueller, R.; Sankaran, S.
10.1101/2025.02.19.638224 — biophysics — Posted on 2025-02-24
1104 Piezo ion channel activation increases the release of therapeutic extracellular vesicles after mechanical stimulation in bioreactors
Andrade, A. C.; Le Goas, O.; Lemieux, S.; Grangier, A.; Nicolai, A.; Guerrera, C.; Ribes, C.; Suply, E.; Volatron, J.; Gazeau, F.; Silva, A. K. A.
10.1101/2025.01.09.632205 — cell biology — Posted on 2025-02-24
1105 Click-Based Determination of Accumulation of Molecules in Escherichia coli
Ongwae, G. M.; Liu, Z.; Feng, S.; Chordia, M. D.; Sharifian Gh., M.; Dash, R.; Dalesandro, B. E.; Guo, T.; Sharpless, K. B.; Dong, J.; Siegrist, M. S.; Im, W.; Pires, M.
10.1101/2023.06.20.545103 — microbiology — Posted on 2025-02-24
1106 Molecular mechanisms of recruitment, function and regulation of UPF1 in histone mRNA decay
Machado de Amorim, A.; Xue, G.; Dittmers, T.; He, W.; Lewandowski, S.; Perez-Borrajero, C.; Bethmann, J.; Mateva, N.; Krage, C.; Nandana, V.; Hennig, J.; Urlaub, H.; Marzluff, W. F.; Chakrabarti, S.
10.1101/2025.02.23.639735 — biochemistry — Posted on 2025-02-24
1107 Immunological characterization of peritoneal exudate cells in liver cirrhosis patients
Kaji, S.; Sasaki, I.; Kunimoto, S.; Wakaki-Nishiyama, N.; Tosuji, E.; Kurara, A.; Kato, T.; Mutsukawa, C.; Okuzaki, D.; Okamoto, C.; Yamano, Y.; Shimizu, R.; Maeshima, S.; Ida, Y.; Yamashita, Y.; Hashimoto, T.; Iwabuchi, S.; Hashimoto, S.; Saitoh, S.-I.; Araki, S.-i.; Kitano, M.; Kaisho, T.
10.1101/2025.02.19.638957 — immunology — Posted on 2025-02-24
1109 Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to Kif18a Inhibition
Kelley, V. M.; Serrano, M. B.; Gasperi, W.; Ader, N.; Lea, H.; Lee, H.; Phoomak, C.; Kabeche, L.; King, M. C.; Contessa, J.
10.1101/2025.02.19.638911 — cancer biology — Posted on 2025-02-24
1111 Magnetic printing and actuation of stretchable muscle tissue
Demri, N.; Morizur, L.; Dumas, S.; Gropplero, G.; MARTINAT, C.; Descroix, S.; Wilhelm, C.
10.1101/2025.02.19.638972 — bioengineering — Posted on 2025-02-24
1112 The novel SCN5A-P1891A mutation is associated with left ventricular hypertrabeculation and links Nav1.5 to cardiomyocyte proliferation and disrupted 3D cardiac tissue formation
Majid, Q. A.; Prajapati, C.; Liu, X.; Kari-Koskinen, J.; Pohjolainen, L.; Karhu, T.; Ruskoaho, H.; Varjosalo, M.; Aalto-Setälä, k.; Talman, V.
10.1101/2025.02.19.639199 — molecular biology — Posted on 2025-02-24
1113 Kupffer cells control neonatal hepatic metabolism via Igf1 signaling
Makdissi, N.; Hirschmann, D. J.; Frolov, A.; Sado, I.; Nikolka, F.; Cheng, J.; Blank-Stein, N.; Viola, M. F.; Yaghmour, M.; Arnold, P.; Bonaguro, L.; Becker, M.; Thiele, C.; Meissner, F.; Hiller, K.; Beyer, M.; Mass, E.
10.1101/2025.02.19.638983 — developmental biology — Posted on 2025-02-24
1115 Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes
Atser, M. G.; Wenyonu, C. D.; Rowe, E. M.; Leung, C. L. K.; Cen, H. H.; Queathem, E. D.; Liu, L. T.; Moravcova, R.; Rogalski, J.; Perrin, D.; Crawford, P.; Foster, L. J.; Alcazar, A.; Johnson, J. D.
10.1101/2024.10.14.618123 — biochemistry — Posted on 2025-02-24
1118 DateBack, a digital open access repository of archaeobotanical data for reconstructing date palm history
Besseiche, M.; Brandstatt, E.; Dabrowski, V.; Chambraud, E.; Sabot, F.; Bouchaud, C.; Gros-Balthazard, M.
10.1101/2025.02.21.639487 — evolutionary biology — Posted on 2025-02-24
1122 Repeatability of protein structural evolution following convergent gene fusions
Konno, N.; Miyake, K.; Nishino, S.; Omae, K.; Yanagisawa, H.; Tsuru, S.; Nishimura, Y.; Kikkawa, M.; Furusawa, C.; Iwasaki, W.
10.1101/2025.02.23.639786 — evolutionary biology — Posted on 2025-02-24
1124 Rapid and repeated evolution of the pigmentation patterns in reef fishes
Frederich, B.; Mittelheiser, L.; Gillet, A.; Hodge, J. R.; Laudet, V.; Dornburg, A.
10.1101/2025.02.21.639431 — evolutionary biology — Posted on 2025-02-24
1125 Disentangling urbanisation, climate effects and their interaction on ornamental colourations
Sandmeyer, L.; Lopez-Idiaquez, D.; Fargevieille, A.; Giovannini, P.; Perret, S.; Del Rey, M.; Charmantier, A.; Doutrelant, C.; Gregoire, A.
10.1101/2025.02.19.639098 — ecology — Posted on 2025-02-24
1128 A distinctive subset of microglia positioned at the paraventricular zone are dedicated to cleaning the cerebrospinal fluid
Zhou, G.; He, J.; Mao, B.; Cheng, G.; Zhang, R.; Wang, Q.; Liu, X.; Zheng, J.; Wang, M.; Zhao, L.; Shi, P.; Shen, X. Z.; Wan, S.
10.1101/2025.02.23.639717 — immunology — Posted on 2025-02-24
1129 Long-term development of a motor memory
Franklin, D. W.; Nietschmann, P.; Papadopoulou, T.; Franklin, S.
10.1101/2025.02.22.639647 — neuroscience — Posted on 2025-02-24
1133 The aging human brain exhibits reduced cerebrospinal fluid flow during sleep due to both neural and vascular factors
Bailes, S. M.; Williams, S. D.; Ashenagar, B.; Licata, J.; Bosli, M. Y.; Dormes, B. J.; Yun, H. J.; Zimmerman, D.; Hernandez Moyers, A.; Salat, D. H.; Lewis, L. D.
10.1101/2025.02.22.639649 — neuroscience — Posted on 2025-02-24
1134 Distinct prelimbic cortex ensembles encode response execution and inhibition
Madangopal, R.; Zhao, Y.; Heins, C.; Zhou, J.; Liang, B.; Barbera, G.; Lam, K. C.; Komer, L. E.; Weber, S. J.; Thompson, D. J.; Gera, Y.; Pham, D. Q.; Savell, K. E.; Warren, B. L.; Caprioli, D.; Venniro, M.; Bossert, J. M.; Ramsey, L. A.; Jedema, H. P.; Schoenbaum, G.; Lin, D.-T.; Shaham, Y.; Pereira, F.; Hope, B. T.
10.1101/2025.02.23.639736 — neuroscience — Posted on 2025-02-24
1135 Surface Expansion Regionalization of the Hippocampus in Early Brain Development
Wang, Y.; Chen, L.; Wu, Z.; Hung, S.-C.; Smith, J. K.; Wang, L.; Li, T.; Lin, W.; Li, G.
10.1101/2025.02.22.639699 — neuroscience — Posted on 2025-02-24
1136 Altered mechanical properties of astrocytes lacking MLC1; implications for the leukodystrophy MLC
Bisseling, Q.; Passchier, E. M. J.; Antonovaite, N.; Camerini, S.; Brignone, M. S.; Freal, A.; Mansvelder, H. D.; Ambrosini, E.; van der Knaap, M. S.; Min, R.
10.1101/2025.02.19.639082 — neuroscience — Posted on 2025-02-24
1137 Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease
Woldeyes, R. A.; Nishiga, M.; Vander Roest, A. S.; Engel, L.; Giri, P.; Montenegro, G. C.; Dunn, A. R.; Spudich, J. A.; Bernstein, D.; Schmid, M. F.; Wu, J. C.; Chiu, W.
10.1101/2023.10.26.564098 — biophysics — Posted on 2025-02-23
1139 Ambient temperature structural studies of Penicillin-binding Protein 2a of Methicillin-Resistant Staphylococcus aureus with XFELs and synchrotrons
Grieco, A.; Quereda-Moraleda, I.; Botha, S.; Dorner, K.; Schmidt, C.; Han, H.; Vakili, M.; Schulz, J.; Koua, F.; de Wijn, R.; Kharitonov, K.; Round, A.; Bielecki, J.; Kupitz, C.; Lisova, S.; Schleissner, P.; Sierra, R.; Mariani, V.; Basu, S.; Orlans, J.; Rose, S.; de Sanctis, D.; Gee, L. B.; Bean, R.; Mobashery, S.; Chang, M.; Hermoso, J.; Martin-Garcia, J. M.
10.1101/2025.02.22.637770 — biochemistry — Posted on 2025-02-23
1141 Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer
Huang, X.; Feng, D.; Mitra, S.; Andretta, E. S.; Hooshdaran, N. B.; Ghelani, A. P.; Wang, E. Y.; Frost, J. N.; Lawless, V. R.; Vancheswaran, A.; Jiang, Q.; Leslie, C. S.; Rudensky, A.
10.1101/2025.02.07.637083 — immunology — Posted on 2025-02-23
1142 The Generalizability of Cortical Area Parcellations Across Early Childhood
Tu, J.; Myers, M.; Li, W.; Li, J.; Wang, X.; Dierker, D.; Day, T.; Snyder, A. Z.; Latham, A.; Kenley, J. K.; Sobolewski, C. M.; Wang, Y.; Labonte, A. K.; Feczko, E.; Kardan, O.; Moore, L. A.; Sylvester, C. M.; Fair, D. A.; Elison, J. T.; Warner, B. B.; Barch, D. M.; Rogers, C. E.; Luby, J. L.; Smyser, C. D.; Gordon, E. M.; Laumann, T. O.; Eggebrecht, A. T.; Wheelock, M. D.
10.1101/2024.09.09.612056 — neuroscience — Posted on 2025-02-23
1144 Mapping the Landscape of Allele-Specific Expression In Porcine Genomes
Yao, W.-y.; Godia, M.; Fang, L.; Groenen, M.; Bai, L.; Li, K.; Madsen, O.
10.1101/2025.02.19.639037 — genomics — Posted on 2025-02-23
1146 The ABCG1 transporter facilitates sesquiterpene accumulation in Marchantia polymorpha oil bodies.
Forestier, E. C. F.; Asprilla Carabali, P.; Romani, F.; Bonter, I.; Frangedakis, E.; Haseloff, J.
10.1101/2025.02.05.636625 — plant biology — Posted on 2025-02-23
1147 Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber, M. K.; Widener, A. E.; Cuaycal, A. E.; Smurlick, D.; Butterworth, E. A.; Lenchik, N. I.; Chen, J.; Beery, M.; Hiller, H.; Verney, E.; Kusmartseva, I.; Slak Rupnik, M.; Campbell-Thompson, M.; Gerling, I. C.; Atkinson, M. A.; Mathews, C. E.; Phelps, E. A.
10.1101/2024.12.29.630665 — physiology — Posted on 2025-02-23
1148 Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome
Xia, L.; Tu, K.; Wang, H.; Liu, X.; Liu, Y.; Zhang, Q.; Feng, Z.; Yu, C.; Li, M.; Huang, Y.; Wang, J.; Wei, R.; Zeng, T.; Pi, X.; Ling, C.; Zhang, Q.; Qiao, Y.; Hou, S.; Zhang, Z.; Wei, A.; Liao, H.; Liu, J.; Wu, Z.; Wang, Z.; Li, A.; Li, W.; Xie, D.
10.1101/2025.02.19.638966 — genomics — Posted on 2025-02-23
1150 Dynamic Monomer-Dimer Transition in Ligand-induced Apelin Receptor Activation
Ji, S.; Wang, W.; Yang, Y.; Xu, P.; Zhang, J.; Zhao, X.; Xi, K.; Zang, S.; Shen, D.; Mao, C.; Shen, Q.; Zhang, Y.
10.1101/2025.02.19.639188 — molecular biology — Posted on 2025-02-23
1151 Dirt floors and domestic animals are associated with soilborne exposure to antimicrobial resistant E. coli in rural Bangladeshi households
Ercumen, A.; Hossain, M. S.; Tabassum, T.; Haque, A.; Rahman, A.; Rahman, M. H.; Anderson, C.; Tazin, S.; Hanif, S.; Barratt Heitmann, G.; Miah, R.; Yeamin, A.; Jahan, F.; Shoab, A. K.; Mahmud, Z. H.; Rahman, M.; Benjamin-Chung, J.
10.1101/2025.02.21.639507 — microbiology — Posted on 2025-02-23
1152 Highly Pathogenic Avian Influenza A (H5N1) Clade 2.3.2.1a virus infection in domestic cats, India, 2025
Raut, A. A.; Aasdev, A.; Kumar, N.; Pathak, A.; Mishra, A.; Sehgal, P.; Pateriya, A.; Pandey, M. K.; Bhatia, S.; Mishra, A.
10.1101/2025.02.23.638954 — microbiology — Posted on 2025-02-23
1153 Co-expression of Bovine leukemia virus and Bovine foamy virus-derived miRNAs in naturally infected cattle
Petersen, M. I.; Suarez Archilla, G.; Perez, C. V.; Gonzalez, D. D.; Trono, K. G.; Mongini, C.; Jaworski, J. P.; Carignano, H. A.
10.1101/2025.02.21.639540 — microbiology — Posted on 2025-02-23
1156 Inhibition of methylthioadenosine phosphorylase provides protection from experimental acute kidney injury
Saliba, A.; Chen, Y.; Nelson, J. W.; Vetcha, A.; Wang, W. W.; Kang, L.; Ragi, N.; Maity, S.; Rabb, H.; Reeves, W. B.; Sharma, K.
10.1101/2025.02.19.639065 — pathology — Posted on 2025-02-23
1157 Distilling structural representations into protein sequence models
Ouyang-Zhang, J.; Gong, C.; Zhao, Y.; Krähenbühl, P.; Klivans, A. R.; Diaz, D. J.
10.1101/2024.11.08.622579 — bioinformatics — Posted on 2025-02-23
1158 Bioinformatics analysis identifies sequence determinants of enzymatic activity for the PHARC associated lipase ABHD12
Chakraborty, A.; Devarajan, A.; Kumar, K.; CS, R.; Madhusudhan, M. S.; RATNAPARKHI, G. S.; Kamat, S.
10.1101/2025.02.19.639194 — biochemistry — Posted on 2025-02-23
1159 Multi-modal Disentanglement of Spatial Transcriptomics and Histopathology Imaging
Maan, H.; Ji, Z.; Sicheri, E.; Tan, T. J.; Selega, A.; Gonzalez, R.; Krishnan, R. G.; Wang, B.; Campbell, K. R.
10.1101/2025.02.19.638201 — genomics — Posted on 2025-02-23
1161 Spatial Total RNA Sequencing of Formalin-Fixed Paraffin Embedded Tissues by spRandom-seq
Liao, Y.; Chen, J.; Zhang, S.; Chen, Y.-s.; Zhu, B.; Chen, H.; Zhu, Y.; Xu, Z.; Yin, Y.; Xiong, X.; Liu, N.; Guo, H.; Wang, Y.
10.1101/2025.02.19.638981 — genomics — Posted on 2025-02-23
1162 Convergent evolution during host range expansion and virulence increase in a Salmonella bacteriophage
Maurin, A.; Vasse, M.; Zarate-Chaves, C.; breyton, C.; Bouzidi, S.; hayer, J.; Dainat, J.; Mesleard-Roux, M.; Weill, F.-X.; Bravo, I. G.; Feugier, A.; Froissart, R.
10.1101/2024.03.13.584857 — evolutionary biology — Posted on 2025-02-23
1163 Basal association of a transcription factor favors early gene expression
Pinheiro, S.; Nadal-Ribelles, M.; Sole, C.; Vincenzetti, V.; Dusserre, Y.; Posas, F.; Pelet, S.
10.1101/2024.03.26.586726 — cell biology — Posted on 2025-02-23
1164 Chromatin retained MUSHER lncRNA integrates ABA and DOG1 signalling pathways to enhance Arabidopsis seeds dormancy.
Sacharowski, S.; Krzyszton, M.; Brzezniak, L.; Rogowski, K. J.; Montez, M.; Rosol, K.; Wrona, M.; Yatusevich, R.; Manjunath, V. H.; Szewc, L.; Jarmolowski, A.; Swiezewski, S.
10.1101/2025.02.19.639109 — molecular biology — Posted on 2025-02-23
1165 PRDM16 controls smooth muscle cell fate in atherosclerosis
Tan, J.; Cheng, L.; Calhoun, R. P.; Weller, A.; Drareni, K.; Fong, S.; Barbara, E.; Lim, H. W.; Xue, C.; Winter, H.; Auguste, G.; Miller, C. L.; Reilly, M.; Maegdefessel, L.; Lutgens, E.; Seale, P.
10.1101/2025.02.19.639186 — molecular biology — Posted on 2025-02-23
1166 A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing
Paatela, E. M.; St. Amant, F. G.; Hamm, D. C.; Bennett, S. R.; Gujral, T. S.; van der Maarel, S. M.; Tapscott, S. J.
10.1101/2025.02.19.639175 — molecular biology — Posted on 2025-02-23
1167 Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis
Ye, J. L.; Grieger, K.; Lu, D.; Brandenberger, C.; Juchem, M.; Jordan, M.; Oehlsen, L.; Zardo, P.; Werlein, C.; Hesse, C.; Sewald, K.; Tretbar, S.; Thum, T.; Chatterjee, S.; Baer, C.
10.1101/2025.02.19.639041 — molecular biology — Posted on 2025-02-23
1171 An integrated meta-omics approach for identifying candidate organic micropollutant degraders in complex microbial communities
Elad, T.; Tang, K.; Pierrelee, M.; Mark Jensen, M.; Bentzon-Tilia, M.; Smets, B. F.; Dechesne, A.; Valverde-Perez, B.
10.1101/2025.02.21.639455 — microbiology — Posted on 2025-02-23
1174 Chalcogen derivatives for the treatment of African trypanosomiasis: biological evaluation of thio and seleno- semicarbazones and their azole derivatives
Rubio-Hernandez, M.; Teixeira, T. R.; Nguyen, T. P.; Shingyoji, M.; Barbosa da Silva, E.; O'Donoghue, A. J.; Caffrey, C. R.; Perez-Silanes, S.; Martinez, N.
10.1101/2025.02.21.639579 — microbiology — Posted on 2025-02-23
1175 Seasonal biogeochemical variations in a modern microbialite reef under early Earth-like conditions
Vignale, F.; Sanchez Garcia, L.; Carrizo, D.; Castillejos Sepulveda, A.; Taubner, H.; Oriolo, S.; Mitchell, A. L.; Turjanski, A.; Klatt, J.; Finn, R. D.; Garcia-Alai, M. M.; Farias, M. E.
10.1101/2025.02.22.639630 — microbiology — Posted on 2025-02-23
1176 Click-Based Determination of Accumulation of Molecules in Escherichia coli
Ongwae, G. M.; Liu, Z.; Feng, S.; Chordia, M. D.; Sharifian Gh., M.; Dash, R.; Dalesandro, B. E.; Guo, T.; Sharpless, K. B.; Dong, J.; Siegrist, M. S.; Im, W.; Pires, M.
10.1101/2023.06.20.545103 — microbiology — Posted on 2025-02-23
1179 A data-driven algorithm to determine 1H-MRS basis set composition
Davies-Jenkins, C. W.; Zollner, H. J.; Simicic, D.; Alcicek, S.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2024.09.11.612503 — neuroscience — Posted on 2025-02-23
1183 High-throughput MicroED for probing ion channel dynamics
Gallenito, M. J.; Clabbers, M. T. B.; Lin, J.; Hattne, J.; Gonen, T.
10.1101/2025.02.19.639122 — biochemistry — Posted on 2025-02-23
1185 The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao, X.-T.; Diep, D. T. V.; Percifull, L.; Fausten, R. M.; Hugenroth, M.; Höhne, P.; Esch, B. M.; Collado, J.; Keller, J.; Wilmes, S.; Wälte, M.; Kümmel, D.; Schuberth, C.; Fernandez-Busnadiego, R.; Fröhlich, F.; Wedlich-Söldner, R.; Bohnert, M.
10.1101/2025.02.21.639583 — cell biology — Posted on 2025-02-23
1187 Deep learning predicts tissue outcomes in retinal organoids
Afting, C.; Bhatti, N.; Schlagheck, C.; Salvador, E. S.; Herrera-Astorga, L.; Agarwal, R.; Suzuki, R.; Hackert, N.; Lorenz, H.-M.; Zilova, L.; Wittbrodt, J.; Exner, T.
10.1101/2025.02.19.639061 — developmental biology — Posted on 2025-02-23
1188 A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation
Steindel, M.; Davis, O.; Neumann, K.; Pirvan, L.; Agsu, G.; Kranz, A.; Adhya, D.; Morf, J.; Yang, S.; Zhang, Z.; Fu, J.; Barile, M.; Wurmser, A.; Strawbridge, S.; Mohorianu, I.; Madapura, P.; Huntly, B.; Gottgens, B.; Holcman, D.; Samarajiwa, S.; Klenerman, D.; Anastassiadis, K.; Stewart, A. F.; Basu, S.
10.1101/2025.02.21.639010 — cell biology — Posted on 2025-02-23
1192 A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver
Yakubovsky, O.; Afriat, A.; Egozi, A.; Bahar Halpern, K.; Barkai, T.; Harnik, Y.; Korem Kohanim, Y.; Novoselsky, R.; Golani, O.; Goliand, I.; Addadi, Y.; Kedmi, M.; Keren-Shaul, H.; Fellus-Alyagor, L.; Hirsch, D.; Mayer, C.; Peri, R.; Pencovich, N.; Timucin, T.; Nachmany, I.; Itzkovitz, S.
10.1101/2025.02.22.639181 — cell biology — Posted on 2025-02-23
1194 Patient-derived organoids to study glycosylation dynamics during gastric disease
Santos-Ferreira, L.; Duarte, H. O.; Moia, E.; Costa, A. F.; Martins, A. M.; Faria-Ramos, I.; Matos, R.; Barros, R.; Silva, M.; Pedrosa, S.; Batista, D. A.; Gomes, J.; Boren, T.; Sousa, F.; Casanova-Goncalves, F.; Barbosa, J.; Magalhaes, A.; Gomes, C.; Santos-Sousa, H.; Bartfeld, S.; Carneiro, F.; Reis, C. A.; Pinto, F.
10.1101/2025.02.21.639100 — cell biology — Posted on 2025-02-23
1195 Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures
Hawgood, M.; Urien, B.; Agostinho, A.; Thiagarajan, P.; Yang, Y.; Zhang, X.; Giglio, G.; Quijada, G.; Fonseca, M.; Bartek, J.; Blom, H.; Lemmens, B.
10.1101/2025.02.21.639251 — cell biology — Posted on 2025-02-23
1197 Circular RNA Circ-Cdr1as modulates Macrophage phenotype and Cardiac Reparative Function by Circ-Cdr1as-miR-7-Klf4 pathway
Kishore, R.; Gonzalez, C.; Cimini, M.; Mallaredy, V.; Benedict, C. L.; Joladarashi, D.; Gurrala, C. T.; Cheng, Z.; Trungcao, M.; Rai, A. K.; Garikipati, V. N. S.
10.1101/2025.02.21.639391 — cell biology — Posted on 2025-02-23
1198 Hematopoietic stem cells undergo bidirectional fate transitions in vivo.
Fukushima, T.; Kristiansen, T. A.; Wong, L. P.; Keyes, S.; Tanaka, Y.; Mazzola, M.; Zhao, T.; He, L.; Yagi, M.; Hochedlinger, K.; Yamazaki, S.; Sadreyev, R. I.; Scadden, D. T.
10.1101/2025.02.23.639689 — cell biology — Posted on 2025-02-23
1200 Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Nardone, C.; Gao, J.; Seo, H.-S.; Mintseris, J.; Ort, L.; Yip, M. C.; Negasi, M.; Besschetnova, A. K.; Kamitaki, N.; Gygi, S. P.; Dhe-Paganon, S.; Munshi, N.; Fulciniti, M.; Greenberg, M. E.; Shao, S.; Elledge, S. J.; Gu, X.
10.1101/2025.02.22.639686 — cell biology — Posted on 2025-02-23
1201 Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs
Nachum-Raines, S.; Gamliel, N.; Wasserman, D.; Qassem, N.; Sher, I.; Guez-Haddad, J.; Emanuele, M. J.; Chill, J. H.; Tzur, A.
10.1101/2025.02.23.639703 — cell biology — Posted on 2025-02-23
1202 Composition and RNA binding specificity of metazoan RNase MRP
Liu, Y.; He, S.; Pyo, K.; Zheng, S.; Chen, M.; Cheloufi, S.; Slavov, N.; Marzluff, W. F.; Murn, J.
10.1101/2025.02.21.639568 — molecular biology — Posted on 2025-02-23
1203 Controlling the Formation of Multiple Condensates in the Synapse
Safari, N.; Lima, M.; Rossetto, R.; Zwicker, D.; D'Este, E.; Tetzlaff, C.
10.1101/2025.02.19.638975 — molecular biology — Posted on 2025-02-23
1204 ProteoAutoNet: high-throughput co-eluted protein analysis with robotics and a multi-database search strategy
Lyu, M.; Chen, Y.; Hu, P.; Zhang, G.; Ma, K.; Zhang, X.; Liu, P.; Zhang, S.; Li, X.; Sun, R.; Guo, T.
10.1101/2025.02.18.638804 — biochemistry — Posted on 2025-02-23
1207 A cocktail of B vitamins with nicotinamide riboside, folate and cobalamin preserves cardiac function and mitochondrial oxidative capacities in a mouse model of heart failure.
Boitard, S. E.; Delouche, M.; Karoui, A.; Gressette, M.; Momken, I.; Bouchard, B.; Mercier-Nome, F.; Imbard, A.; Lemaire, C.; Garnier, A.; Ruiz, M.; MERICSKAY, M.; Piquereau, J.
10.1101/2025.02.18.638803 — physiology — Posted on 2025-02-23
1209 Leishmania amazonensis infection induces IL1β-dependent hyperalgesia, while dampening mechanical allodynia in C57BL/6 mice
Guadagnini Perez, G.; de Lima, E. V.; Antonio, L. S.; Vidal, E. M. M.; Christoff, R. R.; Paiva, M. B.; Goncalves, A. J. S.; Duarte, M. P. O.; Bellio, M.; Coutinho-Silva, R.; da Costa, R.; Figueiredo, R. T.; Clarke, J. R.; de Matos Guedes, H. L.
10.1101/2025.02.18.638800 — pathology — Posted on 2025-02-23
1210 BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance
Chung, O.; Yao, S.; Yang, F.; Wang, L.; Cerda-Smith, C.; Hutchinson, H.; Wood, K. C.; Su, W.; Khasraw, M.; Zou, L.; Ramsden, D. A.; Zhang, Z.
10.1101/2025.02.18.638901 — cancer biology — Posted on 2025-02-23
1211 A genetic signature predicts aggressive paraganglioma sensitivity to dual PI3K-CDK4/6 inhibition therapy
Karna, B.; Gentile, F.; Gulde, S.; De Martino, D.; Maurer, J.; Ganesan, K.; Wang, K.; Bechmann, N.; Rapizzi, E.; Robledo, M.; Arroba, E.; Herzig, S.; Noelting, S.; Mohr, H.; Pellegata, N. S.
10.1101/2025.02.18.638668 — cancer biology — Posted on 2025-02-23
1220 Kidney cortex macrophages prevent the formation of mineral stones by reabsorbing phosphate from the urine
Wang, Y.; Weng, Y.; Ding, X.; Chen, N.; Wang, Q.; Lu, Z.; Gao, Z.; Chen, J.; Han, F.; Shen, X. Z.
10.1101/2025.02.18.638798 — immunology — Posted on 2025-02-23
1225 Growth vs. Diversity: A Time-Evolution Analysis of the Chemical Space
Lopez Perez, K.; Lopez Lopez, E.; Soulage, F.; Felix, E.; Medina Franco, J. L.; Miranda Quintana, R. A.
10.1101/2025.02.18.638937 — bioinformatics — Posted on 2025-02-23
1228 scWGBS-GPT: A Foundation Model for Capturing Long-Range CpG Dependencies in Single-Cell Whole-Genome Bisulfite Sequencing to Enhance Epigenetic Analysis
Liang, C.; Ye, P.; Yan, H.; Zheng, P.; Sun, J.; Wang, Y.; Li, Y.; Ren, Y.; Jiang, Y.; Xiang, J.; Zhang, S.; Jiang, L.; Bai, W.; Ma, X.; Chen, T.; Zuo, W.; Bai, L.; Ouyang, W.; Li, J.
10.1101/2025.02.19.638959 — bioinformatics — Posted on 2025-02-23
1229 TISSLET Tissues-based Learning Estimation for Transcriptomics
Miloudi, A.; Al-Qahtani, A.; Hashir, T.; Chikri, M.; Bensmail, H.
10.1101/2025.02.18.638832 — bioinformatics — Posted on 2025-02-23
1230 Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment
Wacholder, A.; Deutsch, E. W.; Kok, L. W.; van Dinter, J. T.; Lee, J.; Wright, J. C.; Leblanc, S.; Jayatissa, A. H.; Jiang, K.; Arefiev, I.; Cao, K.; Bourassa, F.; Trifiro, F.-A.; Bassani-Sternberg, M.; Baranov, P. V.; Bogaert, A.; Chothani, S.; Fierro-Monti, I.; Fijalkowska, D.; Gevaert, K.; Hubner, N.; Mudge, J. M.; Ruiz-Orera, J.; Schulz, J.; Vizcaino, J. A.; Prensner, J. R.; Brunet, M. A.; Martinez, T. F.; Slavoff, S. A.; Roucou, X.; Chaudhary, J. S.; van Heesch, S.; Moritz, R. L.; Carvunis, A.-R.
10.1101/2025.02.19.639069 — genomics — Posted on 2025-02-23
1234 Target-Specificity and Repeatability in Neuro-Cardiac-Guided TMS for Heart-Brain Coupling
Feng, Z.; Martin, S.; Numssen, O.; Weise, K.; Jing, Y.; Gerardos, G.; Martin, C.; Hartwigsen, G.; Knoesche, T.
10.1101/2025.02.19.638988 — neuroscience — Posted on 2025-02-23
1235 Lack of motor defects and ALS-like neuropathology in heterozygous Sptlc1 Exon 2 deletion mice
Pant, D. C.; Lone, M. A.; Parameswaran, J.; Ma, F.; Dutta, P.; Wang, Z.; Park, J.; Verma, S.; Hornemann, T. A.; Jiang, J.
10.1101/2025.02.18.638951 — neuroscience — Posted on 2025-02-23
1236 Building Multivariate Molecular Imaging Brain Atlases Using the NeuroMark PET Independent Component Analysis Framework
Eierud, C.; Norgaard, M.; Bilgel, M.; Petropoulos, H.; Fu, Z.; Iraji, A.; Matheson, G. J.; Ganz, M.; Pernet, C.; Calhoun, V.
10.1101/2025.02.18.638362 — neuroscience — Posted on 2025-02-23
1237 Population-scale gene expression analysis reveals the contribution of expression diversity to the modern wheat improvement
Zhang, Z.; Ma, S.; Yin, M.; Zhao, C.; Zhao, X.; yu, Y.; Wang, H.; Li, X.; Si, Y.; Niu, J.; Xie, J.; Wang, L.; Wu, J.; Zhang, Y.; Zheng, Q.; Zheng, S.; Jiang, N.; Liu, X.; Ling, H.-Q.; He, F.
10.1101/2025.02.18.638840 — plant biology — Posted on 2025-02-23
1240 N153-linked glycans on envelope protein protect orthoflaviviruses from antibody-mediated clearance
Ting, D. H. R.; Marzinek, J. K.; Wan, C.; Palur, R. V.; Idris, F.; Tan, E. T. X.; Koh, C. W. T.; Lim, X. N.; Thein, T. L.; Lim, C. V.; Ng, C. H.; Buckley, T. S.; Walsh, I.; MacAry, P. A.; Leo, Y. S.; Anand, G. S.; Chan, K. R.; Nguyen-Khuong, T.; Bond, P. J.; ALONSO, S.
10.1101/2025.02.20.639387 — microbiology — Posted on 2025-02-23
1241 Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity
Marian, O. C.; Matis, S.; Dobson-Stone, C.; Kim, W. S.; Kwok, J. B.; Piguet, O.; Halliday, G. M.; Landin-Romero, R.; Don, A. S.
10.1101/2025.02.17.638741 — neuroscience — Posted on 2025-02-23
1242 Corticospinal, reticulospinal, and motoneuronal contributions to fatigability during a sustained contraction of the elbow flexors
Hayman, O.; Brownson-Smith, R.; Atkinson, E.; Spillane, P.; Baker, S.; Goodall, S.; Howatson, G.; Thomas, K.; Ansdell, P.
10.1101/2025.02.17.637601 — neuroscience — Posted on 2025-02-23
1243 Proteomic characterisation of the early rheumatoid arthritis-cardiovascular disease multimorbid axis.
Shukla, R.; Mohammed, A.; Black, N.; Erhayiem, B.; Fent, G. J.; Miller, C. A.; Plein, S.; Plant, D.; Buch, M. H.
10.1101/2025.02.17.638761 — systems biology — Posted on 2025-02-23
1244 Single Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm
Parker, S. J.; Saddic, L.; Kaneda, G.; Momenzadeh, A.; Zilberberg, L.; Song, Y.; Mastali, M.; Kreimer, S.; Hutton, A.; Haghani, A.; Meyer, J. G.
10.1101/2025.02.15.638465 — systems biology — Posted on 2025-02-23
1245 Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice.
Volf, A.; Brust, T. F.; Kobylski, R. R.; Czekner, K. M.; Stahl, E. L.; Cameron, M. D.; Trojniak, A. E.; Aube, J.; Bohn, L. M.
10.1101/2025.02.17.638680 — pharmacology and toxicology — Posted on 2025-02-23
1246 Pharmacological Activation of NO-Sensitive Guanylyl Cyclase Ameliorates Obesity-Induced Arterial Stiffness
Seta, F.; Budbazar, E.; Balmes, A.; Elliott, D.; Peres Tintin, L.; Kopp, T.; Feil, S.; Feil, R.; Schäfer, T. E.
10.1101/2025.02.17.638762 — pharmacology and toxicology — Posted on 2025-02-23
1248 Is Tanimoto a metric?
Surendran, A.; Zsigmond, K.; Lopez Perez, K.; Miranda Quintana, R. A.
10.1101/2025.02.18.638904 — bioinformatics — Posted on 2025-02-23
1250 In vitro reconstitution of minimal human centrosomes
Rios, M. U.; Stachera, W.; Familiari, N. E.; Brito, C.; Surrey, T.; Woodruff, J. B.
10.1101/2025.02.20.639226 — cell biology — Posted on 2025-02-23
1251 Alterations in retinal tau phosphorylation in Alzheimer's disease patients identified by mass spectrometry
Santiago, J.; Poceviciute, D.; Vogel, J.; The Netherlands Brain Bank, ; Brinkmalm, G.; Wennstrom, M.
10.1101/2025.02.17.638688 — neuroscience — Posted on 2025-02-23
1254 Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graph
Musunuri, R. L.; Clarke, W. E.; Zhu, B.; Hooper, W.; Chu, T.; Shelton, J.; Corvelo, A.; Chung, D.; Sundar, S.; Novak, A. M.; Paten, B.; Zody, M. C.; Robine, N.; Narzisi, G.
10.1101/2025.02.18.638852 — bioinformatics — Posted on 2025-02-23
1255 Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity
Castro, K. M.; Ayardulabi, R.; Wehrle, S.; Cui, H.; Georgeon, S.; Schmidt, J.; Xiao, S.; Seraj, N.; Harshbarger, W.; Mallett, C. P.; Vassilev, V.; Saelens, X.; Correia, B.
10.1101/2024.12.17.628867 — biochemistry — Posted on 2025-02-23
1256 Ambient temperature structural studies of Penicillin-binding Protein 2a of Methicillin-Resistant Staphylococcus aureus with XFELs and synchrotrons
Grieco, A.; Quereda-Moraleda, I.; Botha, S.; Dorner, K.; Schmidt, C.; Han, H.; Vakili, M.; Schulz, J.; Koua, F.; de Wijn, R.; Kharitonov, K.; Round, A.; Bielecki, J.; Kupitz, C.; Lisova, S.; Schleissner, P.; Sierra, R.; Mariani, V.; Basu, S.; Orlans, J.; Rose, S.; de Sanctis, D.; Gee, L. B.; Bean, R.; Mobashery, S.; Chang, M.; Hermoso, J.; Martin-Garcia, J. M.; Martin Garcia, J. M.
10.1101/2025.02.22.637770 — biochemistry — Posted on 2025-02-23
1257 The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster
Garcia, G. S.; Othonicar, M. F.; Campos, A. T. P.; Kilbourn, E. A.; Bicego, K. C.; Lerchner, J.; Tennessen, J. M.; Oliveira, M. T.
10.1101/2025.02.20.639223 — biochemistry — Posted on 2025-02-23
1258 A pan-gene catalogue of Asian cultivated rice
Contreras-Moreira, B.; Sharma, E.; Saraf, S.; Naamati, G.; Gupta, P.; Elser, J.; Chebotarov, D.; Chougule, K.; Lu, Z.; Wei, S.; Olson, A.; Tsang, I.; Lodha, D.; Zhou, Y.; Yu, Z.; Zhao, W.; Zhang, J.; Amberkar, S.; Sue-Ob, K.; Martin, M.; McNally, K. L.; Ware, D.; Sun, Z.; Deutsch, E. W.; Copetti, D.; Wing, R. A.; Jaiswal, P.; Dyer, S.; Jones, A. R.
10.1101/2025.02.17.638606 — genomics — Posted on 2025-02-23
1259 Spawning asynchrony and mixed reproductive strategies in a common mass spawning coral
Ricardo, G. F.; Doropoulos, C.; Babcock, R. C.; Adam, A. A. S.; Buccheri, E.; Robledo, N.; Uribe-Palomino, J.; Mumby, P. J.
10.1101/2024.12.06.627154 — ecology — Posted on 2025-02-23
1260 An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L
Nic Aodha, L.; Pokhilko, A.; Rosen, L. U.; Galatidou, S.; Walewska, E.; Belton, C.; Galvao, A.; Okkenhaug, H.; Yu, L.; Nakhuda, A.; Mansfield, B.; Khan, S.; Oxley, D.; Barragan, M.; Kelsey, G.
10.1101/2025.02.20.639225 — developmental biology — Posted on 2025-02-23
1261 Amyloid beta precursor protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)
de Bakker, D. E. M.; Mihaljevic, M.; Gharat, K.; Richter, J.; Bagnoli, S.; van Bebber, F.; Adam, L.; Shamim-Schulze, F.; Ohlenschlaeger, O.; Bens, M.; Cirri, E.; Antebi, A.; Matic, I.; Schneider, A.; Schmid, B.; Cellerino, A.; Kirstein, J.; Valenzano, D. R.
10.1101/2024.10.11.617841 — neuroscience — Posted on 2025-02-23
1262 Arabidopsis REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA Polymerase IV transcription complexes.
Wu, Z.; Xue, Y.; Wang, S.; Shih, Y.-H.; Zhong, Z.; Feng, S.; Draper, J.; Lu, A.; Sha, J.; Li, L.; Wohlschlegel, J.; Wu, K.; Jacobsen, S. E.
10.1101/2025.02.21.639493 — plant biology — Posted on 2025-02-23
1265 The importance of small island populations for the long term survival of endangered large-bodied insular mammals
Aninta, S. G.; Drinkwater, R.; Carmagnini, A.; Deere, N. J.; Priyono, D. S.; Andayani, N.; Winarni, N. L.; Supriatna, J.; Fumagalli, M.; Larson, G.; Galbusera, P.; Macdonald, A.; Greer, D.; Mohamad, K.; Prasetyaningtyas, W. E.; Mustari, A. H.; Williams, J.; Barnett, R.; Shaw, D.; Semiadi, G.; Burton, J.; Seaman, D.; Voigt, M.; Struebig, M.; Brace, S.; Rossiter, S.; Frantz, L.
10.1101/2024.05.23.595221 — evolutionary biology — Posted on 2025-02-23
1268 Long-Term Functional Rescue of Trauma-Induced Vision Loss by a Novel, Small Molecule TrkB Activator
Modgil, S.; Walker, C. L.; Chrenek, M. A.; Grossniklaus, H. E.; McDonald, F. E.; Iuvone, P. M.
10.1101/2025.02.18.638863 — neuroscience — Posted on 2025-02-23
1271 Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
Metheringham, C. L.; Srivastava, A. K.; Thorpe, P.; Maji, A.; Parker, M.; Barton, G. J.; Simpson, G. G.
10.1101/2025.02.18.638636 — plant biology — Posted on 2025-02-23
1272 Triploidy is prominent in the duckweed Lemna minor complex
Michael, T. P.; Hoang, P. T. N.; Abramson, B. W.; Mamerto, A.; Pasaribu, B.; Ernst, E.; Allsing, N.; Braglia, L.; Petrus, S.; Fuchs, J.; Schubert, V.; Hartwick, N.; Wang, M.; Lensink, M.; Duong, T.; Colt, K.; Bog, M.; Sree, K. S.; Morello, L.; Appenroth, K. J.; Schubert, I.; Martienssen, R. A.; Lam, E.
10.1101/2025.02.18.638736 — plant biology — Posted on 2025-02-23
1273 Photoperiod decoder 1 regulates seasonal changes in energy metabolism through the growth hormone signaling pathway
Nakayama, T.; Yamaguchi, T.; Maruyama, M.; Ansai, S.; Kashima, M.; Fontaine, R.; Henkel, C.; Naruse, K.; Yoshimura, T.
10.1101/2025.02.19.638565 — physiology — Posted on 2025-02-23
1275 Discovery of non-opioid receptor protein targets of fentanyl across tissues from animal models and humans using photoaffinity probes
Lin, V. S.; Suazo, K. F.; Kim, D. N.; Leach, D. T.; Sveistyte, A.; Walker, J.; Gorham, L. J.; Schultz, K. J.; Mo, K.-F.; Callister, S. J.; Stratton, K. G.; Lomas, G. X.; Nelson, W. C.; Paurus, V. L.; Lalli, P. M.; Moore, R. J.; Powell, S. M.; Rodriguez, O.; Cort, J. R.; Wright, A. T.
10.1101/2025.02.20.634605 — pharmacology and toxicology — Posted on 2025-02-23
1281 Dynamic Lipidome Reorganization in Response to Heat Shock Stress
Solano, L. E.; Keshet, U.; Reinschmidt, A.; Chavez, Y.; Hulsy, W. D.; Fiehn, O.; Nikolaidis, N.
10.1101/2025.02.18.638884 — bioinformatics — Posted on 2025-02-23
1282 Impact of Long-Term Integrated Nutrient Management Practices on Soil Bacterial Diversity: A 16S rRNA-Based Metagenomic Approach
Ahlawat, V.; Ahalawat, N.; Boora, N.; Dadarwal, R. S.; Dhanda, D.; Sangwan, P.; Kumar, V.; Kumar, R.; Yadav, P. K.
10.1101/2025.02.19.639006 — bioinformatics — Posted on 2025-02-23
1284 Machine learning ensemble identifies distinct age-related response to spaceflight in mammary tissue
Casaletto, J. A.; Zhao, T.; Yeung, J.; Ansari, A.; Raj, A.; Mishra, A.; Fry, A.; Sun, K.; Lee, A.; Sanders, L. M.; Costes, S. V.
10.1101/2025.02.17.638732 — bioinformatics — Posted on 2025-02-23
1291 S. pombe telomerase RNA: secondary structure and flexible-scaffold function
McMurdie, K.; Peeney, A. N.; Mefford, M. A.; Baumann, P.; Zappulla, D. C.
10.1101/2025.02.22.638514 — molecular biology — Posted on 2025-02-23
1292 Involvement of RNase J in CRISPR RNA maturation and degradosome formation in cyanobacteria
Bilger, R.; Drepper, F.; Knapp, B.; Berndt, T.; Landerer, H.; Putzer, H.; Huesgen, P.; Hess, W. R.
10.1101/2025.02.21.638496 — microbiology — Posted on 2025-02-23
1293 GATA2 Mediates Macrophage Proliferation During Atherosclerosis
Aktar, A.; Vrieze, A. M.; Telesnicki, K.; Mun, M.; Wodz, K.; Yin, C.; Cox-Duvall, P.; Nagpal, D.; Heit, B.
10.1101/2025.02.18.638845 — immunology — Posted on 2025-02-23
1294 The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
McCaffrey, E. F.; Delmastro, A.; Fitzhugh, I.; Ranek, J.; Douglas, S.; Peters, J. M.; Fullaway, C. C.; Bosse, M.; Liu, C.; Gillen, C.; Greenwald, N. F.; Anzick, S.; Martens, C.; Winfree, S.; Bai, Y.; Sowers, C.; Goldston, M.; Kong, A.; Boonrat, P.; Bigbee, C. L.; Venugopalan, R.; Maiello, P.; Klein, E.; Rodgers, M. A.; Scanga, C. A.; Lin, P. L.; Kirschner, D. E.; Fortune, S. M.; Bryson, B. D.; Butler, J. R.; Mattila, J.; Flynn, J. L.; Angelo, M.
10.1101/2025.02.18.638923 — immunology — Posted on 2025-02-23
1295 Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autism
Papendorp, C. M.; Nolan, E.; Higashimori, H.; Goicouria, L.; Pieplow, C.; Whitley, K.; Elacio, J.; Nie, D.; Kavanaugh, B.; Best, C. R.; Lizarraga, S. B.; Liu, J. S.-H.
10.1101/2025.02.21.639570 — neuroscience — Posted on 2025-02-23
1298 Biplanar nulling coil system for OPM-MEG using printed circuit boards
Jas, M.; Kamataris, J.; Matsubara, T.; Dong, C.; Motta, G.; Sohrabpour, A.; Ahlfors, S.; Hamalainen, M.; Okada, Y.; Sundaram, P.
10.1101/2025.02.19.638883 — neuroscience — Posted on 2025-02-23
1299 Predicting Neuroplasticity Effects of Continuous Theta Burst Stimulation with Biomarkers from the Motor Evoked Potential TMS Input-Output Curve
Parchure, S.; Xu, Z.; Shah-Basak, P.; Erickson, B. A.; Harvey, D. Y.; Wurzman, R.; McAfee, D.; Sacchetti, D.; Faseyitan, O.; Hamilton, R. H.
10.1101/2025.02.20.638871 — neuroscience — Posted on 2025-02-23
1300 Machine Learning-Based Model for Behavioral Analysis in Rodents: Application to the Forced Swim Test
Della Valle, A.; De Carlo, S.; Sonsini, G.; Pilati, S.; Perali, A.; Ubaldi, M.; Ciccocioppo, R.
10.1101/2025.02.18.638880 — neuroscience — Posted on 2025-02-23
1302 Odor-evoked respiratory responses throughout development in sighted and blind mice
Bouguiyoud, N.; Litaudon, P.; Frasnelli, J.; Garcia, S.; Messaoudi, B.; Mouly, A.-M.; Al Ain, S.; Courtiol, E.
10.1101/2025.02.18.638853 — neuroscience — Posted on 2025-02-23
1304 The preclinical cardiac phenotype of the DE50-MD dog model of Duchenne muscular dystrophy.
Sargent, J.; Fuentes, V. L.; Terry, R.; Riddell, D. O.; Harron, R. C.; Wells, D. J.; Piercy, R. J.
10.1101/2025.02.20.638615 — pathology — Posted on 2025-02-23
1305 Artificial intelligence-enabled automated analysis of transmission electron micrographs to evaluate chemotherapy impact on mitochondrial morphology in triple negative breast cancer
Arriojas, A.; baek, M. L.; Berner, M. J.; Zhurkevich, A.; Hinton, A. O.; Meyer, M. D.; Dobrolecki, L. E.; Lewis, M. T.; Zarringhalam, K.; Echeverria, G. V.
10.1101/2025.02.19.635300 — cancer biology — Posted on 2025-02-23
1310 Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graph
Musunuri, R. L.; Clarke, W. E.; Zhu, B.; Hooper, W.; Chu, T.; Shelton, J.; Corvelo, A.; Chung, D.; Sundar, S.; Novak, A. M.; Paten, B.; Zody, M. C.; Robine, N.; Narzisi, G.
10.1101/2025.02.18.638852 — bioinformatics — Posted on 2025-02-23
1311 Collisional cross-section prediction for multiconformational peptide ions with IM2Deep
Devreese, R.; Nameni, A.; Declercq, A.; Terryn, E.; Gabriels, R.; Impens, F.; Gevaert, K.; Martens, L.; Bouwmeester, R.
10.1101/2025.02.18.638865 — bioinformatics — Posted on 2025-02-23
1318 Suprachiasmatic Neuromedin-S Neurons Regulate Arousal
Wu, Y.; De Luca, R.; Broadhurst, R. Y.; Venner, A.; Sohn, L. T.; Bandaru, S. S.; Schwalbe, D. C.; Campbell, J.; Arrigoni, E.; Fuller, P. M.
10.1101/2025.02.22.639648 — neuroscience — Posted on 2025-02-23
1321 A vectorial code for semantics in human hippocampus
Franch, M.; Mickiewicz, E. A.; Belanger, J.; Chericoni, A.; Chavez, A. G.; Katlowitz, K.; Mathura, R.; Bartoli, E.; Kemmer, S.; Piantadosi, S. T.; Provenza, N.; Watrous, A.; Sheth, S.; Hayden, B.
10.1101/2025.02.21.639601 — neuroscience — Posted on 2025-02-23
1322 Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy
Li, H.; Xie, Z.; Tian, Y.; Lin, B.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Chen, S.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-02-22
1324 It is hard to be small: Inbreeding depression depends on the body size in a threatened songbird
Kubacka, J.; Arantes, L. S.; Herdegen-Radwan, M.; Osiejuk, T. S.; Sparmann, S.; Mazzoni, C. J.
10.1101/2024.04.21.590470 — evolutionary biology — Posted on 2025-02-22
1326 Organo-metal coprecipitation contributes to stable organic carbon fraction in mangrove soil
Hamada, K.; Yimatsa, N.; Ohtsuka, T.; Fujitake, N.; Miyajima, T.; Yokoyama, Y.; Miyairi, Y.; Kida, M.
10.1101/2025.02.15.638410 — ecology — Posted on 2025-02-22
1327 Identification of a Highly Expressed Gene Cluster Likely Coding for Benzene Activation Enzymes in a Methanogenic Enrichment Culture
Toth, C. R. A.; Molenda, O.; Nesbo, C. L.; Luo, F.; Devine, C. E.; Chen, X. C.; Wu, K.; Xiao, J. Z.; Guo, S.; Bawa, N.; Flick, R.; Edwards, E. A.
10.1101/2024.12.15.628547 — microbiology — Posted on 2025-02-22
1328 Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer
Mahmoud, A.; Choi, P. H.; Sukhwa, C.; Pintar, J.; Walch, H.; Zhao, N.; Bermeo, J.; Chung, S.; Raghavan, M.; Bapat, S.; Jiang, Q.; Karagkounis, G.; Meredith, J.; Giarrizzo, M.; Firat, C.; Cercek, A.; Foote, M. B.; Schultz, N.; Chatila, W. K.; Nash, G. M.; Shia, J.; Sanchez-Vega, F.; Larson, S.; Dar, A. C.; Rosen, N.; Ganesh, K.
10.1101/2025.02.17.638725 — cancer biology — Posted on 2025-02-22
1329 Boosting metaproteomics identification rates and taxonomic specificity with MS2Rescore
Van Den Bossche, T.; Declercq, A.; Gabriels, R.; Holstein, T.; Mesuere, B.; Muth, T.; Verschaffelt, P.; Martens, L.
10.1101/2025.02.17.638783 — bioinformatics — Posted on 2025-02-22
1334 Gut3Gel: A High Throughput Mucus Model for Culturing Human Intestinal Microbiota
Suarez, N.; Antunes, M.; Sobral, J.; Silva, C.; Sousa, F.; Garbero, O. V.; Kolkova, A.; Visai, L.; Medana, C.; Visentin, S.; Petrini, P.; van Uden, S.; Pacheco, D. P.
10.1101/2025.02.21.639490 — microbiology — Posted on 2025-02-22
1335 Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression
Kim, J.; Ravichandran, H.; Yoffe, L.; Bhinder, B.; Finos, K.; Singh, A.; Pua, B. B.; Bates, S.; Huang, E. B.; Rendeiro, A. F.; Mittal, V.; Altoriki, N. K.; McGraw, T. E.; Elemento, O.
10.1101/2025.02.19.637138 — cancer biology — Posted on 2025-02-22
1337 Ferritin-mediated iron homeostasis and bacterial shifts underpin drought adaptation in sorghum
Kabir, A. H.; Brailey-Crane, P.; Abdelrahman, M.; Legeay, J.; Ahmed, B.; Tran, L.-S. P.; Bennetzen, J. L.
10.1101/2024.07.19.604343 — plant biology — Posted on 2025-02-22
1338 Neutrophil arrest in myocardial capillaries drives hypoxia and impairs diastolic function in a mouse model of heart failure with preserved ejection fraction
Small, D. M.; Buglione, A. E.; Allan-Rahill, N.; Locke, T.; Elmagid, L. A.; Hovasapian, S.; Kim, R.; Mistry, A. A.; Vaquerano, S. A.; Schaffer, C. B.; Nishimura, N.
10.1101/2025.02.17.638717 — physiology — Posted on 2025-02-22
1342 Which plant traits increase soil carbon sequestration? Empirical evidence from a long-term poplar genetic diversity trial
Field, J. L.; Sloan, B. P.; Craig, M. E.; Calloway, P.; Ottinger, S. L.; Mead, T.; Abramoff, R. Z.; Venegas, M. P.; Chhetri, H. B.; Haiby, K.; Kalluri, U. C.; Muchero, W.; Schadt, C. W.; Mayes, M. A.
10.1101/2025.02.17.638464 — ecology — Posted on 2025-02-22
1344 The Knock-In Atlas: A web resource for targeted protein trap by CRISPR/Cas9 in human and mouse cell lines
Hanai, Y.; Hilario, P. L. L.; Shiraishi, Y.; Kano, N.; Kojima, M.; Murai, K.; Kawai, T.; Okamura, K.
10.1101/2025.02.19.638564 — molecular biology — Posted on 2025-02-22
1345 Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells
Houl, J. H.; Bagheri-Yarmand, R.; Kunnimalaiyaan, M.; Miranda Mendez, P.; Kidd, J. L.; Dadbin, A.; Jurado Ruiz, A.; Parekh, P. A.; Henderson, Y. C.; Chari, N. S.; Thennavan, A. T.; Powell, R. T.; Stephan, C. C.; Zhao, X.; Maniakas, A.; Nurieva, R.; Busaidy, N. L.; Cabanillas, M. E.; Dadu, R.; Zafereo, M.; Wang, J. R.; Lai, S. Y.; Hofmann, M.-C.
10.1101/2025.02.17.637322 — cancer biology — Posted on 2025-02-22
1346 A Chk1-Sp1-CD59 axis of the DNA damage response impedes rituximab-mediated complement-dependent cytotoxicity
Chan, A. S. Y.; Jaynes, P. W.; Anbuselvan, A.; Ong, C. Z. Y.; Hoppe, M. M.; Yong, W. K.; Khanchandani, V.; Lee, J. M.; Mustafa, N.; Azaman, I.; Hoang, P. M.; Hong, G.; Chng, W. J.; Cragg, M. S.; Kappei, D.; Tripodo, C.; Jeyasekharan, A. D.
10.1101/2025.02.17.638751 — cancer biology — Posted on 2025-02-22
1347 Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements
Tiwari, A.; Paithane, U.; Friedlein, J.; Tashiro, K.; Saulnier, O.; Barbosa, K. O.; Trinh, Q.; Hall, B.; Saha, S.; Soni, A.; Nakashima, T.; Bobkov, A. A.; Fujimoto, L. M.; Murad, R.; Maurya, S.; Saraswat, M.; Sarmashghi, S.; Lange, J. T.; Wu, S.; Masihi, M. B.; Ghosh, S.; Hemmati, G.; Chapman, O. S.; Hendrikse, L. D.; James, B.; Luebeck, J.-C.; Eisemann, T.; Tzaridis, T.; Rohila, D.; Leary, R.; Varshney, J.; Konety, B.; Dehm, S. M.; Kawakami, Y.; Beroukhim, R.; Largaespada, D.; Stein, L. D.; Chavez, L.; Suzuki, H.; Weiss, W. A.; Zhao, J.; Deshpande, A.; Wechsler-Reya, R. J.; Taylor, M. D.; Bag
10.1101/2025.02.17.638454 — cancer biology — Posted on 2025-02-22
1352 Acylation of the RTX Toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol
Chacko, F. M.; Ganz, S. M.; Pfitzer-Bilsing, A.; Haensch, S.; Westhoff, P.; Weidtkamp-Peters, S.; Reichert, S. H.; Exterkate, M.; Schmitt, L.
10.1101/2025.02.19.639210 — biochemistry — Posted on 2025-02-22
1354 The Greenland shark genome: insights into deep-sea ecology and lifespan extremes
Yang, K.; Nishiwaki, K.; Mizobata, H.; Asakawa, S.; Yoshitake, K.; Watanabe, Y. Y.; Hussey, N. E.; Kovacs, K. M.; Lydersen, C.; Kadota, M.; Kuraku, S.; Kinoshita, S.
10.1101/2025.02.19.638963 — genomics — Posted on 2025-02-22
1360 Long-range chemical signalling in vivo is regulated by mechanical signals
Pillai, E. K.; Mukherjee, S.; Gampl, N.; McGinn, R. J.; Mooslehner, K. A.; Becker, J.; Winkel, A.; Thompson, A. J.; Franze, K.
10.1101/2024.02.15.580459 — developmental biology — Posted on 2025-02-22
1361 MoDorado: Enhanced detection of tRNA modifications in nanopore sequencing by off-label use of modification callers
Rubsam, F.; Lui-Wei, W.; Sun, Y.; Patel, B. I.; van der Toorn, W.; Piechotta, M.; Dieterich, C.; von Kleist, M.; Ehrenhofer-Murray, A. E.
10.1101/2025.02.18.638820 — molecular biology — Posted on 2025-02-22
1365 Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility
Blackmer-Raynolds, L.; Sampson, M. M.; Kozlov, A.; Yang, A.; Lipson, L. D.; Hamilton, A. M.; Kelly, S. D.; Chopra, P.; Chang, J.; Sloan, S. A.; Sampson, T.
10.1101/2025.02.17.638718 — neuroscience — Posted on 2025-02-22
1367 The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats
Goldberg, M. E.; Blevins, J. E.; Wolden-Hanson, T.; Elfers, C. T.; Chichura, K. S.; Ashlaw, E. F.; den Hartigh, L. J.; Roth, C. L.; Doyle, R. P.
10.1101/2025.01.06.631534 — physiology — Posted on 2025-02-22
1373 Non-invasive and unbiased assessment of thermogenesis in mice through thermal gradient ring
de Melo, P. H.; Pereira, N.; Araujo, R. B.; Festuccia, W. T.; Cunha, T. M.; Leiria, L. O.
10.1101/2025.02.17.638667 — physiology — Posted on 2025-02-22
1374 Dissecting PADI6 function defines oocyte cytoplasmic lattices as regulatory hubs for fundamental cellular processes
Williams, J. P. C.; Auchynnikava, T.; McCarthy, A.; Ojarikre, O. A.; Bertran, M. T.; Weston, A. E.; Leonce, D.; Olsen, J.; Niakan, K. K.; Skehel, M.; Turner, J. M. A.; Walport, L. J.
10.1101/2025.02.21.639491 — developmental biology — Posted on 2025-02-22
1377 An evolutionarily conserved role for separase in the regulation of nuclear lamins
Cipressa, F.; Pennarun, G.; Bosso, G.; Rosignoli, S.; Tullo, L.; Schiralli, N.; Borghi, C.; Paiardini, A.; Goldberg, M. L.; Bertrand, P.; Cenci, G.
10.1101/2025.02.19.638993 — genetics — Posted on 2025-02-22
1378 Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia
Tian, Z.; Li, Y.; Jin, F.; Xu, Z.; Gu, Y.; Guo, M.; Shao, Q.; Liu, Y.; Luo, H.; Wang, Y.; Zhang, S.; Yang, C.; Liu, X.; Ji, X.; Liu, J.
10.1101/2024.06.11.598477 — cell biology — Posted on 2025-02-22
1380 Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape
Schoeberl, U. E.; Fitz, J.; Froussios, K.; Valieris, R.; Makharova, M.; Ourailidis, I.; Bauer, B.; Neumann, T.; Wiedemann, E.-M.; Steininger, M.; Garcia, A. C.; Mastrovito, M.; Mouquet, H.; Silva, I.; Pavri, R.
10.1101/2022.05.21.492925 — immunology — Posted on 2025-02-22
1385 AI-Driven Spatial Transcriptomics Unlocks Large-Scale Breast Cancer Biomarker Discovery from Histopathology
Shulman, E. D.; Campagnolo, E. M.; Lodha, R.; Stemmer, A.; Cantore, T.; Ru, B.; Chang, T.-G.; Biswas, S.; Dhruba, S. R.; Wang, A.; Paul, R.; Kalisetty, S.; Hu, T.; Nasrallah, M.; Rajagopal, S.; Sammut, S.-J.; Lipkowitz, S.; Jiang, P.; Caldas, C.; Knott, S. R.; Hoang, D.-T.; Aldape, K.; Ruppin, E.
10.1101/2024.10.16.618609 — cancer biology — Posted on 2025-02-22
1386 Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
Papadopoli, D.; Palia, R.; Jovanovic, P.; Tabaries, S.; Ciccolini, E.; Sabourin, V.; Igelmann, S.; McLaughlan, S.; Zhan, L.; Kim, H.; Chekkal, N.; Szkop, K. J.; Bertomeu, T.; Zeng, J.; Vassalakis, J.; Afzali, F.; Mzoughi, S.; Guccione, E.; Tyers, M.; Avizonis, D.; Larsson, O.; Postovit, L.-M.; Djuranovic, S.; Ursini-Siegel, J.; Siegel, P. M.; Pollak, M.; Topisirovic, I.
10.1101/2024.10.25.620155 — cancer biology — Posted on 2025-02-22
1389 Beneficial reversal of dominance maintains a resistance polymorphism under fluctuating insecticide selection
Karageorgi, M.; Lyulina, A. S.; Bitter, M. C.; Lappo, E.; Greenblum, S. I.; Mouza, Z. K.; Tran, C. T.; Huynh, A. V.; Oken, H.; Schmidt, P.; Petrov, D. A.
10.1101/2024.10.23.619953 — evolutionary biology — Posted on 2025-02-22
1390 Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival
Munden, A.; Lui, D.; Higgins, D.; Fanelli, M.; Nguyen, T.-K.; Edwards, K.; Ericsson, M.; Godbole, A.; Haley, J.; Lewis, C.; Spinelli, J.; Harrison, B.; Raftery, D.; Djukovic, D.; Promislow, D.; Miller, D.; Walker, A. K.
10.1101/2025.02.20.639242 — cell biology — Posted on 2025-02-22
1391 Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila.
Tassara, F. J.; Barella, M.; Simo, L.; Folgueira, M.; Rodriguez-Caron, M.; Ispizua, J. I.; Ellisman, M. H.; de la Iglesia, H. O.; Ceriani, M. F.; Gargiulo, J.
10.1101/2024.11.06.622263 — neuroscience — Posted on 2025-02-22
1392 Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
Sauter, K. A.; Webb, G. M.; Bader, L.; Kreklywich, C. N.; Takahashi, D. L.; Zaro, C.; McGuire, C. M.; Lewis, A. D.; Colgin, L. M. A.; Kirigiti, M. A.; Blomenkamp, H.; Pessoa, C.; Humkey, M.; Hulahan, J.; Sleeman, M.; Zweig, R. C.; Thomas, S.; Thomas, A.; Gao, L.; Hirsch, A. J.; Levy, M.; Cherry, S. R.; Kahn, S. E.; Slifka, M. K.; Sacha, J. B.; Kievit, P.; Roberts, C.
10.1101/2025.02.18.638792 — pathology — Posted on 2025-02-22
1396 Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci
Hecker, D.; Song, X.; Baumgarten, N.; Diagel, A.; Katsaouni, N.; Li, L.; Li, S.; Kumar Maji, R.; Behjati Ardakani, F.; Ma, L.; Tews, D.; Wabitsch, M.; Björkegren, J. L. M.; Schunkert, H.; Chen, Z.; Schulz, M. H.
10.1101/2025.02.20.639228 — bioinformatics — Posted on 2025-02-21
1397 A scalable approach to investigating sequence-to-expression prediction from personal genomes
Spiro, A. E.; Tu, X.; Sheng, Y.; Sasse, A.; Hosseini, R.; Chikina, M.; Mostafavi, S.
10.1101/2025.02.21.639494 — genomics — Posted on 2025-02-21
1399 A Myosin Nanomotor Essential for Stereocilia Maintenance Expands the Etiology of Hereditary Hearing Loss DFNB3
Behnammanesh, G.; Dragich, A. K.; Liao, X.; Hadi, S.; Kim, M.-J.; Perrin, B. J.; Someya, S.; Frolenkov, G. I.; Bird, J. E.
10.1101/2025.02.19.639121 — neuroscience — Posted on 2025-02-21
1400 The impact of testosterone on paraventricular nucleus gene expression in male and female spontaneously hypertensive rats
Paterson, A.; Loh, S.-Y.; Gholami, S. K.; Rogers, M. F.; Murugan, D. D.; Lam, S.-K.; Mustafa, M. R.; Ott, B. P.; Balaratnam, P.; Mecawi, A. d. S.; Murphy, D.; Hindmarch, C. C.
10.1101/2025.02.20.639267 — neuroscience — Posted on 2025-02-21
1402 Non-invasive approach for endoluminal biopsy coupled with single-cell proteomics allows for immune characterization of intracranial aneurysms
Antonios, J.; Gultekin, B.; Theriault, B.; Yalcin, K.; Miyagishima, D.; Adenu-Mensah, N.; Sujijantarat, N.; Koo, A.; Haynes, J.; Cedeno, P.; Johnson, M.; Hebert, R.; Matouk, C.; Barak, T.; Gunel, M.
10.1101/2025.02.17.638658 — physiology — Posted on 2025-02-21
1403 Resolution of in situ inflammation in human lupus nephritis into principal immune cell trajectories
Casella, G.; Torcasso, M.; Ai, J.; Cao, T.; Hara, S.; Andrade, M.; Ghosh, D.; Chang, A.; Ko, K.; Chong, A. S.; Giger, M.; Clark, M.
10.1101/2025.02.17.638655 — immunology — Posted on 2025-02-21
1408 Bioactive Flavonoid Extract Suppresses NLRP3 Activation and Inflammation in 2D and 3D Lung Models
El Sabbagh, D. E. S.; de Souza, D. V.; Pappis, L.; Davidson, C. B.; Mangos, M.; Wang, A.; Cypel, M.; Attisano, L.; Machado, A. K.; Andreazza, A.
10.1101/2025.02.20.639357 — molecular biology — Posted on 2025-02-21
1412 RB-TnSeq elucidates dicarboxylic acid specific catabolism in β-proteobacteria for improved plastic monomer upcycling
Pearson, A. N.; Lynch, J. M.; Ho, C. N.; Hudson, G. A.; Roberts, J. B.; Menasalvas, J.; Vilchez, A. A.; Incha, M. R.; Schmidt, M.; Mukhopadhyay, A.; Deutschbauer, A. M.; Thompson, M. G.; Shih, P.; Keasling, J. D.
10.1101/2025.02.21.639450 — microbiology — Posted on 2025-02-21
1414 JAK inhibitors remove innate immune barriers to allow viral propagation
Ravlo, E.; Ianevski, A.; Skipperstoen, M.; Lysvand, H.; Schjolberg, J.-O.; Vapalahti, O.; Smura, T.; Vauhkonen, H.; Oksenych, V.; Weber, F.; Strand, M.; Evander, M.; Malmring, J.; Afset, J. E.; Bjoras, M.; Kainov, D. E.
10.1101/2025.02.17.638720 — immunology — Posted on 2025-02-21
1416 Environmentally Relevant Lead Exposure Alters Cell Morphology and Expression of Neural Hallmarks During SH-SY5Y Neuronal Differentiation
Morgan, R. K.; Tapaswi, A.; Polemi, K. M.; Miller, J.; Sexton, J.; Bakulski, K.; Svoboda, L. K.; Dolinoy, D. C.; Colacino, J.
10.1101/2025.02.17.638689 — neuroscience — Posted on 2025-02-21
1417 AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network
Fadini, A.; Li, M.; McCoy, A. J.; Terwilliger, T. C.; Read, R. J.; Hekstra, D. R.; AlQuraishi, M.
10.1101/2025.02.18.638828 — biophysics — Posted on 2025-02-21
1418 Dissecting Force Transmission across SUN Proteins Using Nuclear Tension Sensors
Wang, J.; Qiu, J.; Lu, S.; Ding, S.; Xu, F.; Luo, Y.; Zhou, J.; Peng, Q.
10.1101/2025.02.17.638756 — biophysics — Posted on 2025-02-21
1420 Evaluation of Metagenome Binning: Advances and Challenges
Arangasamy, Y.; Morice, E.; Jochheim, A.; Lieser, B.; Soeding, J.
10.1101/2025.02.21.639465 — bioinformatics — Posted on 2025-02-21
1421 Agent-based modeling of cellular dynamics in adoptive cell therapy
Wang, Y.; Casarin, S.; Daher, M.; Mohanty, V.; Dede, M.; Shanley, M.; Basar, R.; Rezvani, K.; Chen, K.
10.1101/2025.02.17.638701 — bioinformatics — Posted on 2025-02-21
1423 Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi.
De Freitas Nascimento, J.; Barison, M. J.; Montanaro, G. T.; Marchese, L.; Ornitz, R.; Silva, L. S.; Guarneri, A. A.; Silber, A. M.
10.1101/2025.02.19.639176 — biochemistry — Posted on 2025-02-21
1424 Chemical inhibition of a bacterial immune system
Zang, Z.; Duncan, O. K.; Sabonis, D.; Shi, Y.; Miraj, G.; Fedorova, I.; Le, S.; Deng, J.; Zhu, Y.; Cai, Y.; Zhang, C.; Arya, G.; Duerkop, B. A.; Liang, H.; Bondy-Denomy, J.; Ve, T.; Tamulaitiene, G.; Gerdt, J. P.
10.1101/2025.02.20.638879 — biochemistry — Posted on 2025-02-21
1425 Genome modeling and design across all domains of life with Evo 2
Brixi, G.; Durrant, M. G.; Ku, J.; Poli, M.; Brockman, G.; Chang, D.; Gonzalez, G. A.; King, S. H.; Li, D. B.; Merchant, A. T.; Naghipourfar, M.; Nguyen, E.; Ricci-Tam, C.; Romero, D. W.; Sun, G.; Taghibakshi, A.; Vorontsov, A.; Yang, B.; Deng, M.; Gorton, L.; Nguyen, N.; Wang, N. K.; Adams, E.; Baccus, S. A.; Dillmann, S.; Ermon, S.; Guo, D.; Ilango, R.; Janik, K.; Lu, A. X.; Mehta, R.; Mofrad, M. R. K.; Ng, M. Y.; Pannu, J.; Re, C.; Schmok, J. C.; St. John, J.; Sullivan, J.; Zhu, K.; Zynda, G.; Balsam, D.; Collison, P.; Costa, A. B.; Hernandez-Boussard, T.; Ho, E.; Liu, M.-Y.; McGrath, T.; P
10.1101/2025.02.18.638918 — genomics — Posted on 2025-02-21
1430 Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-G-F Knock in Mouse Model
Okhovat, M.; Layman, C.; Davis, B. A.; Pederson, A.; O'Niel, A.; Holden, S.; Kessler, K.; Acharya, S.; Wheeler, K. J.; Nevonen, K. A.; Herrera, J.; Ward, S.; Vigh-Conrad, K.; Adey, A.; Raber, J.; Carbone, L.
10.1101/2025.02.20.639336 — molecular biology — Posted on 2025-02-21
1431 A novel method for detection of Cas9 gRNAs using a fluorophore-labeled DNA oligo
Bandara, R. A.; Chen, Z.; Zhou, P.; Duan, C.; Davidson, A. R.; Wong, A.; Hu, J.
10.1101/2025.02.21.639318 — molecular biology — Posted on 2025-02-21
1433 An integrated DNA interactome and transcriptome profiling reveals a PU.1/enhancer RNA-mediated Feed-forward Regulatory Loop Regulating monocyte/macrophage development and innate immune functions
Waliullah, A.; Qiu, K.; Dziegielewska, B.; Tran, M. L.; Nguyen, N. N.; Wang, L.; Pan, A.; Segovia, N.; Umarino, S.; Zhang, J.; Nguyen, T. M.; Craig, J.; Tenen, D. G.; Trinh, B.
10.1101/2025.02.19.638695 — molecular biology — Posted on 2025-02-21
1434 In vitro and in vivo Antiviral Activity of the Acyclic Nucleoside Phosphonate Prodrug LAVR-289 against Poxvirus and African Swine Fever Virus Replication
Marcheteau, E.; Mosca, E.; Frenois-Veyrat, G.; Kappler-Gratias, S.; Boutin, L.; Top, S.; Mathieu, T.; Colas, C.; Favetta, P.; Garnier, T.; Barbe, P.; Keck, M.; Gillet, D.; Mas, A.; Alejo, A.; Yu, Y.; Toth, K.; Abate, G.; Roy, V.; Skerry, J.; Wetzel, K. S.; Joshua, S. D.; Joseph, G. W.; Panchal, R. G.; Mucker, E. M.; Mudhasani, R.; Agrofoglio, L. A.; Iseni, F.; Gallardo, F.
10.1101/2025.02.20.634468 — microbiology — Posted on 2025-02-21
1436 Stochastic Regression and Peak Delineation with Flow Cytometry Data
Kearsley, A. J.; Parratt, K. H.; Pinheiro, G. L.; Da Silva, S. M.
10.1101/2025.02.21.639492 — microbiology — Posted on 2025-02-21
1438 Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin
Pena Alzua, G.; Leon, A. N.; Yellin, T.; Bhavsar, D.; Loganathan, M.; Bushfield, K.; Brouwer, P. J. M.; Rodriguez, A. J.; Jeevan, T.; Webby, R. J.; Marizzi, C.; Han, J.; Ward, A.; Duty, J. A.; Krammer, F.
10.1101/2025.02.21.639446 — microbiology — Posted on 2025-02-21
1439 Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia
Larcombe, S. D.; Paxton, E.; Vrettou, C.; Steketee, P. C.; Matthews, K. R.; Morrison, L. J.; Briggs, E. M.
10.1101/2025.02.21.639415 — microbiology — Posted on 2025-02-21
1441 Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice
Sutton, E. R.; McCallion, E.; Hoolachan, J. M.; Cetin, O.; Pacheco-Torres, P.; Bouhmidi, S.; Churchill, L.; Scaife, T.; Chaytow, H.; Huang, Y.-T.; Duguez, S.; Schneider, B. L.; Gillingwater, T. H.; Dimitriadi, M.; Bowerman, M.
10.1101/2025.02.17.638672 — pharmacology and toxicology — Posted on 2025-02-21
1443 FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
Li, J. T.-Y.; Amiri, M.; Kailasam, S.; Sun, J.; Sonenberg, N.; Ortega, J.; Sossin, W. S.
10.1101/2025.02.21.639553 — neuroscience — Posted on 2025-02-21
1450 Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Lejeune, A.; Zhou, C.; Ercelen, D.; Putzel, G.; Yao, X.; Guy, A. R.; Pawline, M.; Podkowik, M.; Pironti, A.; Torres, V. J.; Shopsin, B.; Cadwell, K.
10.1101/2024.07.17.603994 — immunology — Posted on 2025-02-21
1455 Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans
Rosenthal, Z.; Majeski, J.; Somarowthu, A.; Quinn, D.; Lindquist, B.; Putt, M.; Karaj, A.; Favilla, C.; Baker, W.; Hosseini, G.; Rodriguez, J.; Cristancho, M.; Sheline, Y.; Shuttleworth, B.; Abbott, C.; Yodh, A.; Goldberg, E.
10.1101/2024.10.31.621357 — neuroscience — Posted on 2025-02-21
1456 Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy in EGFR-mutated non-small cell lung cancer
Nakamura, S.; Shibahara, D.; Tanaka, K.; Kishikawa, Y.; Hashisako, M.; Nakatomi, K.; Nakagaki, N.; Kohno, M.; Azuma, K.; Ibusuki, R.; Otsubo, K.; Yoneshima, Y.; Iwama, E.; Oda, Y.; Okamoto, I.
10.1101/2025.02.10.637543 — cancer biology — Posted on 2025-02-21
1457 YAP controls cell migration and invasion through a Rho-GTPase switch
Shah, S. R.; Ren, C.; Tippens, N. D.; Park, J.; Mohyeldin, A.; Wang, S.; Vela, G.; Martinez-Gutierrez, J. C.; Margolis, S. S.; Schmidt, S.; Xia, S.; Quinones-Hinojosa, A.; Levchenko, A.
10.1101/602052 — cancer biology — Posted on 2025-02-21
1458 Wounding triggers invasive progression in human basal cell carcinoma
Yerly, L.; Andreatta, M.; Garnica, J.; Di Domizio, J.; Gilliet, M.; Carmona, S. J.; Kuonen, F.
10.1101/2024.05.31.596823 — cancer biology — Posted on 2025-02-21
1459 Enzymatic carbon-fluorine bond cleavage by human gut microbes
Probst, S. I.; Felder, F. D.; Poltorak, V.; Mewalal, R.; Blaby, I. K.; Robinson, S. L.
10.1101/2024.07.15.601322 — biochemistry — Posted on 2025-02-21
1464 Comprehensive epitope mutational scan database enables accurate T cell receptor cross-reactivity prediction
Banerjee, A.; Pattinson, D. J.; Wincek, C. L.; Bunk, P.; Axhemi, A.; Chapin, S. R.; Navlakha, S.; Meyer, H. V.
10.1101/2024.01.22.576714 — immunology — Posted on 2025-02-21
1468 A temporary challenge by tumor cells can lead to a permanent partial-impairment of memory CD8 T cell function
Laubreton, D.; Prieux, M.; Djebali, S.; Dubois, M.; De Bernard, S.; Gandrillon, O.; Christophe, A.; marvel, j.
10.1101/2025.02.17.638652 — immunology — Posted on 2025-02-21
1469 Rationally Designed PKD1 Activator Protects Against Neurodegeneration in Pre-clinical Models of Parkinson's Disease
Asaithambi, A.; Jang, A.; Ghosh, A.; Ay, M.; Jin, H.; Anantharam, V.; Kanthasamy, A.; Kanthasamy, A. G.
10.1101/2025.02.13.637661 — neuroscience — Posted on 2025-02-21
1470 Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex
Franklin, A.; Davies, J.; Clifton, N.; Blake, G.; Bamford, R.; Walker, E.; Chioza, B.; Frith, M.; Burrage, J.; Owens, N.; Prabhakar, S.; Dempster, E.; Hannon, E.; Mill, J.
10.1101/2025.02.21.639467 — genomics — Posted on 2025-02-21
1471 Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue
Aakhte, M.; Mueller, G. F.; Li, J.; Weiss, K. R.; Roos, L.; Diniz, A. M.; Wenzel, J.; Schwaninger, M.; Moser, T.; Huisken, J.
10.1101/2025.02.21.639411 — developmental biology — Posted on 2025-02-21
1473 CAR T cell engineering impacts antigen-independent activation and co-inhibition
Stuecheli, S.; Schultheiss, C.; Schmidt-Barbo, P.; Zingg, A.; Franz, N.; Adamo, S.; Fischer, C.; Laubli, H.; Binder, M.
10.1101/2025.01.20.631849 — immunology — Posted on 2025-02-21
1474 Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics
Lakunina, A.; Socha, K. Z.; Ladd, A.; Bowen, A. J.; Chen, S.; Colonell, J.; Doshi, A.; Karsh, B.; Krumin, M.; Kulik, P.; Li, A.; Neutens, P.; O'Callaghan, J.; Olsen, M.; Putzeys, J.; Tilmans, H. A. C.; Ye, Z.; Welkenhuysen, M.; Hausser, M.; Koch, C.; Ting, J.; Neuropixels Opto Consortium, ; Dutta, B.; Harris, T. D.; Steinmetz, N. A.; Svoboda, K.; Siegle, J. H.; Carandini, M.
10.1101/2025.02.04.636286 — neuroscience — Posted on 2025-02-21
1475 Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome
Ecker, A.; Egas Santander, D.; Abdellah, M.; Blanco Alonso, J.; Bolanos-Puchet, S.; Chindemi, G.; Gowri Mariyappan, D. P.; Isbister, J. B.; King, J. G.; Kumbhar, P.; Magkanaris, I.; Muller, E. B.; Reimann, M. W.
10.1101/2023.08.07.552264 — neuroscience — Posted on 2025-02-21
1476 Adaptive time course of the skeletal muscle proteome during programmed resistance training in rats
Stead, C. A.; Hesketh, S. J.; Viggars, M. R.; Thomas, A. C. Q.; Sutherland, H.; Jarvis, J. C.; Burniston, J. G.
10.1101/2025.02.17.633647 — physiology — Posted on 2025-02-21
1480 A screen to identify antifungal antagonists reveals a variety of pharmacotherapies induce echinocandin tolerance in Candida albicans.
Reitler, P.; DeJarnette, C.; Kumar, R.; Tucker, K. M.; Peters, T. L.; Twarog, N. A.; Shelat, A. A.; Palmer, G. E.
10.1101/2025.02.18.638903 — microbiology — Posted on 2025-02-21
1482 Investigating Cement-Based Surfaces as a Sustainable Flooring Solution to Improve Ascaris Egg Removal and Inactivation in Low-Resource Settings
Anderson, C.; Hanif, S.; Hernandez, J.; Crider, Y.; Lepech, M.; Billington, S. L.; Boehm, A. B.; Benjamin-Chung, J.
10.1101/2025.02.18.638796 — microbiology — Posted on 2025-02-21
1483 Food pairing independently associated with cardiometabolic traits beyond dietary patterns across western and eastern populations
Deng, Q.; Sun, Y.; Gu, M.; Fu, J.; Xu, F.; Jiao, Y.; Zhou, Y.; Ma, B.; Liu, L.; Wang, X.; Dong, Q.; Wu, T.; Zou, H.; Shi, J.; Wang, Y.; Sheng, Y.; Tang, L.; Sun, W.; Li, A.; Hu, S.; Zheng, J.-S.; He, Y.; Zhou, H.; Wu, W.; Kong, X.; Chen, L.
10.1101/2025.01.03.631167 — microbiology — Posted on 2025-02-21
1484 Immunological and clinical markers of post-acute sequelae of COVID-19: Insights from mild and severe cases six months post-infection
Mouton, W.; Djebali, S.; Villard, M.; Allatif, O.; Chauvel, C.; Benezech, s.; Vanhems, p.; MARVEL, J.; Walzer, T.; Trouillet-Assant, S.
10.1101/2025.02.18.638851 — immunology — Posted on 2025-02-21
1486 China Autism Brain Imaging Consortium: Charting Brain Growth in Chinese Children with Autism
Li, L.; Bai, M.; Cai, K.; Cao, D.; Cao, X.; Chen, J.; Fan, X.-R.; Gao, P.; Gao, W.; He, D.; Meng, F.; Jiang, X.; Ni, L.; Li, X.; Lin, L.; Liu, Y.; Liu, Z.; Pan, N.; Qi, Q.; Qin, B.; Shan, X.; Shou, X.; Wang, L.; Wang, M.; Wang, X.; Xu, D.; Xu, Y.; Xue, Y.; Yang, T.; Zhang, Y.; Cai, J.; Chen, H.; Chen, A.; Jia, F.; Jiang, H.; Jing, J.; Li, T.; Li, S.; Wang, W.; Wang, J.; Wu, L.; Yin, X.; Zhang, R.; Zuo, X.-N.; China Autism Brain Imaging Consortium, ; Duan, X.
10.1101/2025.02.20.639044 — neuroscience — Posted on 2025-02-21
1490 Dopamine and serotonin differentially associated with reward and punishment processes in humans: A systematic review and meta-analysis
Mkrtchian, A.; Qiu, Z.; Abir, Y.; Erdmann, T.; Dercon, Q.; Sedlinska, T.; Browning, M.; Costello, H.; Huys, Q. J. M.
10.1101/2025.01.08.631868 — neuroscience — Posted on 2025-02-21
1491 Frontal Theta Oscillations and Cognitive Flexibility: Age-Related Modulations in EEG Activity
Darna, M.; Stolz, C.; Jauch, H. S.; Strumpf, H.; Hopf, J. M.; Seidenbecher, C. I.; Schott, B. H.; Richter, A.
10.1101/2024.07.05.602082 — neuroscience — Posted on 2025-02-21
1495 Transcriptome analysis of the winter tick (Dermacentor albipictus) reveals sex-specific expression patterns
Edwards, R. T. M.; Antoshechkin, I.; Hill, E.; Perry, M. W.; Olafson, P. U.; Saelao, P.; Lohmeyer, K. H.; Akbari, O. S.
10.1101/2025.02.17.638687 — genomics — Posted on 2025-02-21
1497 Conspecific brood parasitism in the barn swallow (Hirundo rustica)
Jelinek, V.; Mari, L.; Petrzelkova, A.; Albrechtova, J.; Cepak, J.; Kuhn, S.; Munclinger, P.; Tomasek, O.; Sulc, M.; Albrecht, T.
10.1101/2025.01.31.635828 — ecology — Posted on 2025-02-21
1499 KEAP1 retention in phase-separated p62 bodies drives liver damage in autophagy-deficient conditions
Komatsu, M.; Takada, S.; Shinomiya, N.; Mao, G.; Tsuchiya, H.; Koga, T.; Komatsu-Hirota, S.; Sou, Y.-S.; Abe, M.; Ryzhii, E.; Suzuki, M.; Nakao, M.; Waguri, S.; Morishita, H.
10.1101/2025.02.21.639409 — cell biology — Posted on 2025-02-21
1501 Glycyl-tRNA sequestration is a unifying mechanism underlying GARS1-associated peripheral neuropathy
Mora, N.; Slot, E. F. J.; Lewandowski, V.; Menafra, M. P.; Mallik, M.; van Lith, P.; Sijlmans, C.; van Bakel, N.; Ignatova, Z.; Storkebaum, E.
10.1101/2024.10.11.617948 — neuroscience — Posted on 2025-02-21
1503 MOSHPIT: accessible, reproducible metagenome data science on the QIIME 2 framework
Ziemski, M.; Gehret, L.; Simard, A.; Castro Dau, S.; Risch, V.; Grabocka, D.; Matzoros, C.; Wood, C.; Momo Cabrera, P.; Hernandez-Velazquez, R.; Herman, C.; Evans, K.; Robeson, M. S.; Bolyen, E.; Caporaso, J. G.; Bokulich, N. A.
10.1101/2025.01.27.635007 — bioinformatics — Posted on 2025-02-21
1510 Alternate dyes for image-based profiling assays
Sivagurunathan, S.; Byrne, P. J.; Munoz, A. F.; Arevalo, J.; Carpenter, A. E.; Singh, S.; Kost-Alimova, M.; Cimini, B. A.
10.1101/2025.02.19.639058 — cell biology — Posted on 2025-02-21
1511 Teach your microscope how to print: Low-cost and rapid-iteration microfabrication for biology
Hinderling, L.; Hadorn, R.; Kwasny, M.; Frei, J.; Graedel, B.; Psalmon, S.; Blum, Y.; Berthoz, R.; Landolt, A.; Towbin, B. D.; Riveline, D.; Pertz, O.
10.1101/2025.02.20.639256 — cell biology — Posted on 2025-02-21
1512 Glyco-STORM: Nanoscale Mapping of the Cellular Glycosylation Landscape
Schroeter, H. G.; Sass, S.; Heilemann, M.; Kuner, T.; Klevanski, M.
10.1101/2025.02.19.639131 — cell biology — Posted on 2025-02-21
1513 Metabolically purified human stem cell-derived hepatocytes reveal distinct effects of Ebola and Lassa viruses
Prescott, J. B.; Liu, K. J.; Lander, A.; Pek, N. M. Q.; Jha, S. K.; Bokelmann, M.; Begur, M.; Koh, P. W.; Yang, H.; Lim, B.; Red-Horse, K.; Weissman, I. L.; Loh, K. M.; Ang, L. T.
10.1101/2025.02.17.638665 — cell biology — Posted on 2025-02-21
1514 Characterisation of CD4 Th subsets as well as dietary, exercise and lifestyle factors in an established Rheumatoid Arthritis cohort; pilot study.
Venkataraman, S.; D'Cunha, N.; Kozlovskaia, M.; Naumovski, N.; McKune, A.; Bruestle, A.; Xu, T.; Marie, J. C.; Hernandez-Vargas, H.; Dorai Raj, A.; Tsai, T.; Pyne, D.; Goldsmith, C.
10.1101/2025.02.16.638543 — immunology — Posted on 2025-02-21
1515 Cerebellar and Subcortical Contributions to Working Memory Manipulation
Tan, J. B. C.; Orlando, I. F.; Whyte, C.; Bryant, A. G.; Munn, B. R.; Baracchini, G.; King, M.; O'Callaghan, C.; Müller, E. J.; Shine, J. M.
10.1101/2025.02.20.639399 — neuroscience — Posted on 2025-02-21
1516 Neuronal development shapes activity-dependent gene expression in a stimulus-specific manner
Lukin, J.; Beckel, M. S.; Pedroncini, O.; Giusti, S. A.; Linenberg, I. M.; Patop, I. L.; Chernomoretz, A.; Marin-Burgin, A.; Kadener, S.; Refojo, D.
10.1101/2025.02.19.638694 — neuroscience — Posted on 2025-02-21
1518 Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma
Hancock, S. E.; Garthwaite, L.; Harellis, K.; Susetio, M.; Ding, E.; Choong, L.; Contreras, O.; Nguyen, A.; Lising, J.; Hansen, F. K.; Wongsomboon, P.; Menzel, J. P.; Poad, B. L.; Mitchell, T. W.; Blanksby, S. J.; Turner, N.
10.1101/2024.12.18.628624 — cancer biology — Posted on 2025-02-21
1520 Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation
Batra, S.; Olmo, F.; Ragan, T. J.; Frank, A. M.; Kaplan, M.; Lancey, C.; Assadipapari, M.; Ying, C.; Struwe, W. B.; Hesketh, E.; Kelly, J. M.; Barfod, L.; Campeotto, I.
10.1101/2024.03.26.586384 — biophysics — Posted on 2025-02-21
1524 Understanding monocyte-driven neuroinflammation in Alzheimers disease using human brain organoid microphysiological systems
Tian, C.; Ao, Z.; Cerneckis, J.; Cai, H.; Chen, L.; Niu, H.; Takayama, K.; Kim, J.; Shi, Y.; Gu, M.; Kanekiyo, T.; Guo, F.
10.1101/2025.02.16.638539 — bioengineering — Posted on 2025-02-21
1529 Effects of a Sequential Application of Plant Protection Products on Soil Microbes and Free-Living Nematodes in a Field Experiment
Drocco, C.; Fernandes, S.; Xie, L.; Devers, M.; Foerster, B.; Martin-Laurent, F.; Romdhane, S.; Spor, A.; Thiour-Mauprivez, C.; Coors, A.
10.1101/2025.02.17.638612 — ecology — Posted on 2025-02-21
1532 Linking molecular pathways and islet cell dysfunction in human type 1 diabetes
dos Santos, T.; Dai, X. Q.; Jones, R. C.; Spigelman, A. F.; Mummey, H. M.; Ewald, J. D.; Ellis, C. E.; Lyon, J. G.; Smith, N.; Bautista, A.; Manning Fox, J. E.; Neff, N. F.; Detweiler, A.; Tan, M.; Arrojo e Drigo, R.; Xia, J.; Camunas-Soler, J.; Gaulton, K. J.; Quake, S. R.; MacDonald, P. E.
10.1101/2025.02.20.639325 — cell biology — Posted on 2025-02-21
1534 Two-million-year-old microbial communities from the Kap Kobenhavn Formation in North Greenland
Fernandez-Guerra, A.; Wörmer, L.; Borrel, G.; Delmont, T. O.; Elberling, B.; Elvert, M.; Eren, A. M.; Gribaldo, S.; Jochheim, A.; Henriksen, R. A.; Hinrichs, K.-U.; Korneliussen, T. S.; Krupovic, M.; Larsen, N. K.; Laso-Perez, R.; Pedersen, M. W.; Pedersen, V. K.; Ruter, A. H.; Sand, K. K.; Sikora, M.; Steinegger, M.; Veseli, I. A.; Zhao, L.; Wang, Y.; Zure, M.; Kjaer, K. H.; Willerslev, E.
10.1101/2023.06.10.544454 — microbiology — Posted on 2025-02-21
1536 Characterization of neurite and soma organization in the brain and spinal cord with diffusion MRI
Schilling, K.; Palombo, M.; Witt, A. A.; O'Grady, K. P.; Pizzolato, M. P.; Landman, B. A.; Smith, S. A.
10.1101/2025.02.19.638936 — neuroscience — Posted on 2025-02-21
1539 The forkhead transcription factor FKH-7/FOXP acts in chemosensory neurons to regulate developmental decision-making
Chai, C. M.; Taylor, S. R.; Tischbirek, C. H.; Wong, W.-R.; Cai, L.; Miller, D. M.; Sternberg, P. W.
10.1101/2025.02.17.638733 — neuroscience — Posted on 2025-02-21
1542 Selective attention and sensitivity to auditory disturbances in a virtually-real Classroom: Comparison of adults with and without AD(H)D
Levy, O.; Libman Hackmon, S.; Zvilichovsky, Y.; Korisky, A.; Bidet-Caulet, A.; Schweitzer, J. B.; Zion Golumbic, E.
10.1101/2024.04.17.590012 — neuroscience — Posted on 2025-02-21
1544 Characterization of bronchovascular-bundle mesenchymal stromal cells regulating antibody-secreting cell niche in rejecting lung allografts
McLinden, A. P.; Ibuki, Y.; Tadokoro, K.; Walker, N. M.; Lu, L.; Ke, F.; Vittal, R.; Farver, C. F.; Welch, J.; Lama, V. N.
10.1101/2025.02.16.638532 — pathology — Posted on 2025-02-21
1547 RNA Knowledge-Graph analysis through homogeneous embedding methods
Torgano, F.; Soto-Gomez, M.; Zignani, M.; Gliozzo, J.; Cavalleri, E.; Mesiti, M.; Casiraghi, E.; Valentini, G.
10.1101/2025.02.17.638592 — bioinformatics — Posted on 2025-02-21
1550 Sheathless elasto-inertial focusing of sub-25 nm particles in straight microchannels
Tanriverdi, S.; Cruz, J.; Habibi, S.; Sych, T.; Costa, M.; Martensson, G.; Gorgens, A.; EL Andaloussi, S.; Brandt, L.; Tammisola, O.; Sezgin, E.; Russom, A.
10.1101/2025.02.16.638527 — bioengineering — Posted on 2025-02-21
1552 Comparative analysis of novel Pseudobdellovibrionaceae genera and species yields insights into the genomics and evolution of bacterial predation mode
Maher, R. L.; Wülbern, J.; Zimmermann, J.; Yeh, E.; Benda, L.; Repnik, U.; Fuss, J.; Künzel, S.; Schulenburg, H.; Bohannan, B. J. M.; Adair, K. L.; Johnke, J.
10.1101/2025.02.19.638989 — genomics — Posted on 2025-02-20
1553 An evolutionarily conserved role for separase in the regulation of nuclear lamins
Cipressa, F.; Pennarun, G.; Bosso, G.; Rosignoli, S.; Tullo, L.; Schiralli, N.; Borghi, C.; Paiardini, A.; Goldberg, M. L.; Cenci, G.
10.1101/2025.02.19.638993 — genetics — Posted on 2025-02-21
1554 A multiomic network approach uncovers disease modifying mechanisms of inborn errors of metabolism
Bender, A.; Ranea-Robles, P.; Williams, E.; Mirzaian, M.; Heimel, J. A.; Levelt, C. N.; Wanders, R. J. A.; Aerts, J. M.; Zhu, J.; Auwerx, J.; Houten, S. M.; Argmann, C.
10.1101/2025.02.19.639093 — genetics — Posted on 2025-02-21
1555 Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways
Brachmann, M. K.; Costa, A. P. B.; Robertson, S.; Donoghue, K.; Pilakouta, N.; Whitehead, M.; Liu, X.; Kristjansson, B.; Skulason, S.; Selman, C.; Parsons, K.
10.1101/2025.02.17.638600 — evolutionary biology — Posted on 2025-02-20
1560 Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone
Field, D. L.; Stankowski, S.; Reiter, T.; Polechova, J.; Bradley, D.; Richardson, D.; Pal, A.; Shipilina, D.; Boell, L.; Pickup, M.; Xue, Y.; Coen, E.; Barton, N. H.
10.1101/2025.02.17.638607 — evolutionary biology — Posted on 2025-02-20
1568 Computational Platform for streamlining the success of sequential antibiotic therapy
Anderson, A.; Kinahan, M.; Blanco, R.; Gonzalez, A. H.; Udekwu, K.; Hernandez Vargas, E. A.
10.1101/2025.02.16.638553 — evolutionary biology — Posted on 2025-02-21
1569 Chemical diversity promotes ecosystem function
Fonvielle, J.; Sandor, S. R.; Dittmar, T.; Tanentzap, A. J.
10.1101/2025.02.16.638531 — ecology — Posted on 2025-02-21
1571 Amniotic Fluid Reduces Liver Fibrosis By Attenuating Hepatic Stellate Cell Activation
Bowen, C. M.; Ditmars, F.; Liu, N.; Abril, J. M.; Ajasin, D.; Russell, W. K.; Stevenson, H. L.; Eugenin, E. A.; Fair, J. H.; Fagg, W. S.
10.1101/2025.02.20.639215 — cell biology — Posted on 2025-02-20
1572 Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex
Sloan, N.; Mares, J.; Daly, A. C.; Coie, L.; Grier, S.; Barretto, N.; Casel, O.; Kang, K.; Jackson, C.; Pedersen, M.; Khiste, S.; Fullerton, B.; Petrescu, J.; Mattison, C.; Smith, C.; Suh, Y.; Menon, V.; Phatnani, H.
10.1101/2025.02.19.639091 — cell biology — Posted on 2025-02-20
1573 Contrasting responses of control and fibrotic lung fibroblasts to fibrotic stimuli: the role of osteoprotegerin in extracellular matrix remodeling
Liu, Y.; Nizamoglu, M.; Zhao, F.; Borghuis, T.; Koster, T.; Sharma, P. K.; Harmsen, M. C.; Thomas, M. J.; White, E. S.; Kasmi, K.; Heijink, I. H.; Melgert, B. N.; Burgess, J. K.
10.1101/2025.02.20.639137 — cell biology — Posted on 2025-02-20
1574 A Single Mutation in TRPC6 Protects Mice from Acute Lung Injury by Regenerating Endothelium
Anwar, M.; Raghunathrao, V. A. B.; Amin, R.; Vellingiri, V.; Joshi, J. C.; Akhter, M. Z.; Tauseef, M.; El-Erian, I. H.; Khaki, N.; Fancher, I. S.; Abdelkarim, H.; Levitan, I.; Chronis, K.; Gaponenko, V.; Mehta, D.
10.1101/2025.02.19.639142 — cell biology — Posted on 2025-02-20
1577 Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration
Hou, J.; Song, Y.; Xiao, C.; Sun, Y.; Shen, J.; Ma, X.; Zhou, Q.; Chiu, S.-C.; Xu, Y.; Huang, Y.; Chen, Y.-G.; Zhu, X.; Wang, J.; Xiong, J.-W.
10.1101/2025.02.19.639191 — cell biology — Posted on 2025-02-21
1579 Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate
Thayer, J. A.; Petersen, J. D.; Huang, X.; Hawrot, J.; Ramos, D. M.; Sekine, S.; Li, Y.; Ward, M. E.; Narendra, D. P.
10.1101/2025.02.19.639160 — cell biology — Posted on 2025-02-21
1580 Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival
Munden, A.; Lui, D.; Higgins, D.; Fanelli, M.; Nguyen, T.-K.; Edwards, K.; Ericsson, M.; Godbole, A.; Haley, J.; Lewis, C.; Spinelli, J.; Harrison, B.; Raftery, D.; Djukovic, D.; Promislow, D.; Miller, D.; Walker, A. K.
10.1101/2025.02.20.639242 — cell biology — Posted on 2025-02-21
1581 Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation
Gokhale, A.; Mendez-Vazquez, H.; Sampson, M. M.; Moctezuma, F. G. R.; Harbuzariu, A.; Sing, A.; Zlatic, S. A.; Roberts, A. M.; Prajapati, M.; Roberts, B. R.; Bartnikas, T. B.; Wood, L. B.; Sloan, S. A.; Faundez, V.; Werner, E.
10.1101/2025.02.16.638529 — neuroscience — Posted on 2025-02-20
1589 Direct mechanical communication of cellular to nuclear shape in oocytes
Vos, B. E.; Vadapalli, Y.; Muenker, T. M.; Jentoft, I. M. A.; Todisco, E.; Eskandari, M. A.; Schuh, M.; Lenart, P.; Betz, T.
10.1101/2025.02.17.638579 — biophysics — Posted on 2025-02-20
1590 Structural basis of ATP release and ion selectivity in Pannexin1 channels
Zhang, Q.; Wang, J.; Gaullier, G.; Blikstad, C.; Kotol, D.; Dahl, G.; Barro Soria, R.; Mim, C.
10.1101/2025.02.17.638584 — biophysics — Posted on 2025-02-20
1594 The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance
Cano-Gamez, K.; Maclean, P.; Inoue, M.; Hussainy, S.; Foss, E.; Wainwright, C.; Qin, H.; McKechnie, S.; Song, C.-X.; Knight, J. C.
10.1101/2025.02.17.638622 — genomics — Posted on 2025-02-20
1597 Assessment of sexual dimorphism in Desmodus rotundus (Chiroptera: Phyllostomidae), a rabies reservoir in Latin America
Cifuentes-Rincon, A.; Sarmiento-Arias, K. D.; Soler-Tovar, D.; Rodriguez-Bolanos, A.; Reyes-Amaya, N.; Bravo-Garcia, C.; Avila-Vargas, L.; Escobar, L. E.
10.1101/2025.02.17.638589 — ecology — Posted on 2025-02-20
1600 The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation
Yang, X.; He, F.; Porter, D. F.; Garbett, K.; Meyers, R. M.; Reynolds, D. L.; Duy, L. H. B.; Hong, A.; Ducoli, L.; Siprashvili, Z.; Lopez-Pajares, V.; Mondal, S.; Ko, L.; Jing, Y.; Tao, S.; Singal, B.; Sando, R.; Skiniotis, G.; Khavari, P. A.
10.1101/2025.02.19.639154 — cell biology — Posted on 2025-02-20
1601 CILIATED CELL DOMAINS WITH LOCALLY COORDINATED CILIARY MOTION GENERATE A MOSAIC OF MICROFLOWS IN THE BRAIN'S LATERAL VENTRICLES
Mellanson, K.; Zhou, L.; Michurina, T. V.; Mikhailik, A.; Samaras, D.; Benveniste, H.; Enikolopov, G.; Peunova, N.
10.1101/2025.02.19.638730 — cell biology — Posted on 2025-02-20
1602 IFN-α Induces Heterogenous ROS Production in Human β-Cells
Wagner, L. E.; Melnyk, O.; Turner, A.; Duffett, B. E.; Muralidharan, C.; Martinez-Irizarry, M. M.; Arvin, M. C.; Orr, K. S.; Manduchi, E.; Kaestner, K. H.; Brozinick, J. T.; Linnemann, A. K.
10.1101/2025.02.19.639120 — cell biology — Posted on 2025-02-20
1603 Synaptic vesicle glycoprotein 2 enables viable aneuploidy following centrosome amplification
Blackmer, J.; Jezuit, E.; Chakraborty, A.; Montague, R.; Peterson, N.; Outlaw, W.; Fox, D. T.
10.1101/2025.02.19.639165 — cell biology — Posted on 2025-02-20
1604 VDAC isoforms play distinct roles in modulating metabolism and maintaining mitochondrial function
Rajendran, M.; Rosencrans, W. M.; Fitzgerald, W.; Huynh, D.; Beyene, B. G.; Quan, B.; Hwang, J.; Bautista, N. A.; Chou, T.-F.; Bezrukov, S. M.; Rostovtseva, T. K.
10.1101/2025.02.20.639106 — cell biology — Posted on 2025-02-20
1605 Fatty acid synthesis supports tumor progression through keeping TORC1 receptive for Insulin/PI3K signaling
Karolyi, D.; Botor, B. S.; Neuhauser, N.; Peter, M.; Balogh, G.; O'Farrell, F.; Takats, S.
10.1101/2025.02.19.639068 — cell biology — Posted on 2025-02-20
1607 Themis and Grb2 form a constitutive structural hub in T cell receptor signalling
Savvides, S. N.; Clancy, D. M.; Sanjuan, A. S.; Gilis, E.; Tougaard, P.; Velghe, I.; Van Droogenbroeck, Y.; Felix, J.; Bloch, Y.; Cuadrado, A. F.; Merceron, R.; Schenk, S.; Vandenabeele, P.; Brunner, J. D.; TAGHON, T.; Elewaut, D.
10.1101/2025.02.16.638521 — immunology — Posted on 2025-02-20
1609 Early resident NK cell response to local HIV infection in lymphoid tissue
Perea, D.; Gonzalez, A.; Sanchez-Gaona, N.; Pumarola, F.; Ortiz, N.; Llano, I.; Lorente, J.; Falco, V.; Genesca, M.; Buzon, M. J.
10.1101/2025.02.17.638403 — immunology — Posted on 2025-02-20
1610 Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation
Ollendorff, M. K.; Chofflet, N.; Bicer, D.; Skeldal, S.; Duan, J.; Feller, B.; Vilstrup, J.; Groth, R.; Sivagurunathan, S.; Dashti, H.; Pedersen, J. S.; Werge, T.; Borglum, A.; Cimini, B. A.; Jones, T. R.; Claussnitzer, M.; Madsen, P.; Takahashi, H.; Demontis, D.; Thirup, S.; Glerup, S.
10.1101/2025.02.16.638491 — neuroscience — Posted on 2025-02-20
1611 Reactive Pericytes Lead to Microvascular Dysfunction and Cortical Neurodegeneration During Experimental Autoimmune Encephalomyelitis
YOUSEFI, M.; Özkan, A.; Kutay Özmen, K.; Uysalli, Y.; Mamipour, M.; Akkaya, N.; Dalal Amandi, A.-R.; Atbasi, A.; Heidarzadeh, M.; Evren Erdener, S.; Kawakami, N.; Kiraz, A.; Gürsoy Özdemir, Y.; Vural, A.
10.1101/2025.02.17.638582 — neuroscience — Posted on 2025-02-20
1612 Effects of Drought on Inflorescence Yield, and Secondary Metabolites in Cannabis sativa L.
Shenhar, I.; Ifrach, I.; Barkan, O.; Guberman, O.; Kerem, Z.; Taler, D.; Meiri, D.; Moshelion, M.
10.1101/2025.02.16.638548 — plant biology — Posted on 2025-02-20
1613 The small molecule ML233 is a direct inhibitor of tyrosinase function
Menard, R.; Baanannou, A.; Halluin, C.; Morse, D.; Kuhn, S.; Graber, J. H.; Strickland, J.; Madelaine, R.
10.1101/2025.02.16.638443 — pharmacology and toxicology — Posted on 2025-02-20
1615 Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA
Carrie, H.; Sim, N. L.; Wong, P. M.; Gan, A.; Lau, Y. T.; Poon, P.; Thangaraju, S.; Tan, I. B.; Yap, Y. S.; Krishnamachari, K.; Wong, L. S.; Skanderup, A. J.
10.1101/2025.02.16.638482 — bioinformatics — Posted on 2025-02-20
1617 FlowerPatch: New Method to Measure Nectar Volume in Artificial Flowers
Lara-Perez, E. R.; Agosto-Rivera, J.; Giray, T.; Megret-Laboye, R.; Florez-Gomez, E.
10.1101/2025.02.16.638513 — bioengineering — Posted on 2025-02-20
1622 DACIT: Device for Axon - Cancer cell Interaction Testing in 2D and 3D
Velazquez Quesada, I.; Alizadeh, V.; Allison, K.; Belova, E.; Kallogjerovic, S.; Hesketh, N.; Zhang, X.; Thomas, G.; Tuzel, E.; Gligorijevic, B.
10.1101/2024.02.26.582218 — cancer biology — Posted on 2025-02-20
1623 Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells
Safa, B. T.; Rosenbohm, J.; Esfahani, A. M.; Minnick, G.; Moghaddam, A. O.; Lavrik, N. V.; Huang, C.; Charras, G.; Kabla, A.; Yang, R.
10.1101/2024.07.31.606021 — biophysics — Posted on 2025-02-20
1626 Iridescent structural coloration in a crested Cretaceous enantiornithine bird from Jehol Biota
LI, Z.; Hu, J.; Stidham, T.; Ye, M.; Wang, M.; Pan, Y.; Zhao, T.; Li, J.; Zhou, Z.; Clarke, J.
10.1101/2024.10.21.619362 — evolutionary biology — Posted on 2025-02-20
1628 Maladaptation in cereal crop landraces following a soot-producing climate catastrophe
McLaughlin, C.; Shi, Y.; Viswanathan, V.; Sawers, R. J.; Kemanian, A.; Lasky, J. R.
10.1101/2024.05.18.594591 — evolutionary biology — Posted on 2025-02-20
1631 Plasticity in inhibitory networks improves pattern separation in early olfactory processing
Joshi, S.; Haney, S.; Wang, Z.; Locatelli, F.; Lei, H.; Smith, B.; Cao, Y.; Bazhenov, M.
10.1101/2024.01.24.576675 — neuroscience — Posted on 2025-02-20
1637 Hypoxia-Induced Cardiopulmonary Remodeling and Recovery: Critical Roles of the Proximal Pulmonary Artery, Macrophages, and Exercise
Ramachandra, A. B.; Sharma, P.; De Man, R.; Nikola, F.; Guerrera, N.; Doddaballapur, P.; Cavinato, C.; Choi, R.; Raredon, M. S. B.; Szafron, J. M.; Zhang, Z.; Barnthaler, T.; Justet, A.; Akingbesote, N. D.; Abu Hussein, N.; Diggs, L.; Perry, R. J.; Adams, T. S.; Singh, I.; Kaminski, N.; Yan, X.; Tellides, G.; Humphrey, J.; Manning, E. P.
10.1101/2025.02.15.638455 — physiology — Posted on 2025-02-20
1638 Reference-free variant calling with local graph construction with ska lo (SKA)
Derelle, R.; Madon, K.; Hellewell, J.; Rodriguez-Bouza, V.; Arinaminpathy, N.; Lalvani, A.; Croucher, N. J.; Harris, S. R.; Lees, J. A.; Chindelevitch, L.
10.1101/2024.10.02.616334 — bioinformatics — Posted on 2025-02-20
1642 Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
Perino, M. G.; Calvo-Rubio Barrera, M.; Riordon, D.; Agnetti, G.; Tarasov, K.; Parveen, A.; Chakir, K.; Morrell, C.; Ahmet, I.; Lyashkov, A.; Lukyanenko, Y.; Tarasova, Y.; Qu, J.; Kadioglu, H.; Ranek, M.; deCabo, R.; Lakatta, E.
10.1101/2023.08.13.553128 — cell biology — Posted on 2025-02-20
1643 Molecular Mechanism of pH Sensing and Activation in GPR4 Reveals Proton-Mediated GPCR Signaling
Xu, H. E.; YOU, C.; GUO, S.; ZHANG, T.; He, X.; GAO, T.; XIN, W.; ZHU, Z.; LU, Y.; XU, Y.; LI, Z.; ZHANG, Y.; Cheng, X.; JIANG, Y.; XIE, X.
10.1101/2025.02.16.638498 — molecular biology — Posted on 2025-02-20
1644 LAVR-289, a new acyclo-nucleoside phosphonate having broad-spectrum activity against herpesviruses.
Kappler-Gratias, S.; Quentin-Froignant, C.; Marcheteau, E.; Fernandez, J.; Boutolleau, D.; Garcia, V.; Roy, V.; Agrofoglio, L. A.; Gallardo, F.
10.1101/2025.02.20.639249 — microbiology — Posted on 2025-02-20
1645 The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses.
Schipper, J.; Aloise, C.; Sutter, S. O.; Zwaagstra, M.; van Vliet, A. L. W.; Abdelnabi, R.; Ignacio, B.; Bonger, K. M.; Roelofs, D.; van den Brand, J. M. A.; Wubbolts, R.; Bruurs, L. J. M.; Thibaut, H. J.; Neyts, J.; Tanenbaum, M. E.; van Kuppeveld, F. J. M.
10.1101/2025.02.20.639337 — microbiology — Posted on 2025-02-20
1646 Microbes display broad diversity in cobamide preferences
Mok, K. C.; Sokolovskaya, O. M.; Deutschbauer, A. C.; Carlson, H. K.; Taga, M. E.
10.1101/2024.11.04.621602 — microbiology — Posted on 2025-02-20
1647 Heterogeneous T cell responses across Hepatitis B virus clinical phases revealed by rapid whole-blood HBV T cell analysis
Le Bert, N.; Koffas, A.; Kumar, R.; Facchetti, F.; Tan, A. T.; Gill, U. S.; Mak, L.-Y.; Stretch, S. W.; Miao, T.; Hariharaputran, S.; Hang, S. K.; Guo, Y.; Chen, Q.; Degasperi, E.; Lampertico, P.; Chow, W. C.; Bertoletti, A.; Kennedy, P. T.
10.1101/2025.02.11.637593 — immunology — Posted on 2025-02-20
1650 Reliability of structural brain change in cognitively healthy adult samples.
Vidal-Pineiro, D.; Sorensen, O.; Stromstad, M.; Amlien, I. K.; Anderson, M.; Baare, W. F. C.; Bartres-Faz, D.; Brandmaier, A. M.; Brathen, A. C.; Garrido, P.; Ghisletta, P.; Grydeland, H.; Henson, R. N.; Kievit, R. A.; Korbmacher, M.; Kuhn, S.; Lindenberger, U.; Mowinckel, A. M.; Nyberg, L.; Roe, J. M.; Sneve, M. H.; Sole-Padulles, C.; Watne, L.-O.; Walhovd, K. B.; Fjell, A. M.
10.1101/2024.06.03.592804 — neuroscience — Posted on 2025-02-20
1651 Human precentral gyrus neurons link speech sequences from listening to speaking
Xu, D.; Chung, J. E.; Silva, A. B.; Greicius, Q. R.; Metzger, S. L.; Zhang, Y.; Leonard, M. K.; Aghi, M. K.; Hervey-Jumper, S. L.; Chang, E. F.
10.1101/2024.12.27.630563 — neuroscience — Posted on 2025-02-20
1654 Increased TGFβ /Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus
Boronat-Belda, T.; Ferrero, H.; Soriano, S.; Ribes-Garcia, E.; Betoret-Gustems, R.; Martinez-Banon, D.; Serrano-Selva, M.; Martinez-Pinna, J.; Nadal, A.; Quesada, I.; Alonso-Magdalena, P.
10.1101/2025.02.16.638404 — physiology — Posted on 2025-02-20
1656 Optimization of the prostaglandin F2α receptor for structural biology
Salze, M.; Chretien, S.; Boora, T.; Macovei, M.; Barbeau, E.; Blais, V.; Laporte, S.; Audet, M.
10.1101/2025.02.15.638479 — pharmacology and toxicology — Posted on 2025-02-20
1662 Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
Montez, M.; Zhu, D.; Huertas, J.; Maristany, M. J.; Rutjens, B.; Nielsen, M. L.; Collepardo-Guevara, R.; Dean, C.
10.1101/2025.02.17.638618 — molecular biology — Posted on 2025-02-20
1667 Etiology and epidemiology of branch dieback and fruit blight and necrosis of English walnut in France
Belair, M.; Picot, A.; Masson, C.; Hebrard, M.-N.; Debled, M.; Moronvalle, A.; Richard, B.; Treguer, S.; Morvant, L.; Henri-Sanvoisin, A.; Laloum, Y.; Le Floch, G.; Pensec, F.
10.1101/2025.02.20.639244 — microbiology — Posted on 2025-02-20
1668 LAVR-289, a New Orally Bioavailable Inhibitor of Adenovirus Replication in vitro and in vivo.
Quentin-Froignant, C.; Tollefson, A.; Cline-Smith, A.; Kappler-Gratias, S.; Landrein, N.; Roy, V.; Agrofoglio, L. A.; Toth, K.; Wodrich, H.; Gallardo, F.
10.1101/2025.02.20.639236 — microbiology — Posted on 2025-02-20
1669 Arginine metabolism has a pivotal function for the encystation of Giardia duodenalis
Klotz, C.; Leisering, R.; Hagen, K. D.; Starcevich, H. N.; Ewald, C.; Türken, S.; Marquardt, M.; Schramm, S.; Ehret Kasemo, T.; Marek, S.; Seeber, F.; Ignatius, R.; Dawson, S. C.; Aebischer, T.
10.1101/2025.02.20.639220 — microbiology — Posted on 2025-02-20
1670 Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster
Ehrhardt, E.; Whitehead, S. C.; Namiki, S.; Minegishi, R.; Siwanowicz, I.; Feng, K.; Otsuna, H.; FlyLight Project Team, ; Meissner, G. W.; Stern, D.; Truman, J.; Shepherd, D.; Dickinson, M. H.; Ito, K.; Dickson, B. J.; Cohen, I.; Card, G. M.; Korff, W.
10.1101/2023.05.31.542897 — neuroscience — Posted on 2025-02-20
1672 Parameter Efficient Fine-tuning of Transformer-based Masked Autoencoder Enhances Resource Constrained Neuroimage Analysis
Dhinagar, N. J.; Ozarkar, S. S.; Buwa, K. U.; Thomopoulos, S. I.; Owens-Walton, C.; Laltoo, E.; Jagad, C.; Chen, Y.-L.; Cook, P.; McMillan, C.; Tsai, C.-C.; Wang, J.-J.; Wu, Y.-R.; Thompson, P. M.
10.1101/2025.02.15.638442 — neuroscience — Posted on 2025-02-20
1675 Joint linear modeling of transcriptomics and proteomics is predictive of cancer metastasis
Sharma, R.; Meimetis, N.; Begzati, A.; Nagar, S. D.; Kellman, B.; Baghdassarian, H. M.
10.1101/2025.02.15.638428 — systems biology — Posted on 2025-02-20
1676 Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation
Puiggene, O.; Munoz-Trivino, J.; Civil-Ferrer, L.; Gille, L.; Schulz-Mirbach, H.; Bergen, D.; Erb, T. J.; Ebert, B. E.; Nikel, P. I.
10.1101/2025.02.17.638773 — synthetic biology — Posted on 2025-02-20
1677 Loss of plasma membrane conductance in outside-xylem zone explains non-stomatal control of transpiration
Jain, P.; Sen, S.; Rockwell, F. E.; Twohey, R. J.; Huber, A. E.; Desai, S. A.; Wu, I.-F.; Swaef, T. D.; Ilman, M. M.; Studer, A.; Holbrook, N. M.; Stroock, A. D.
10.1101/2025.02.15.638441 — plant biology — Posted on 2025-02-20
1687 Behavioural separation of face memory and face perception
Kadlec, J.; Walsh, C. R.; Wilf, M.; Rissman, J.; Ramot, M.
10.1101/2025.02.17.638018 — neuroscience — Posted on 2025-02-20
1688 Individuality across environmental context in Drosophila melanogaster
Mathejczyk, T.; Knief, C.; Haidar, M. A.; Freitag, F.; McClary, T.; Wernet, M. F.; Linneweber, G. A.
10.1101/2023.11.26.568741 — neuroscience — Posted on 2025-02-20
1689 Transcription factors associated with regulation of transcriptome in human thigh and calf muscles at baseline and after six days of disuse
Borzykh, A.; Makhnovskii, P.; Ponomarev, I.; Vepkhvadze, T.; Lednev, E.; Rukavishnikov, I.; Orlov, O.; Tomilovskaya, E.; Popov, D. V.
10.1101/2024.12.10.627667 — physiology — Posted on 2025-02-20
1691 Multidirectional effect of low-intensity neuromuscular electrical stimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse
Borzykh, A. A.; Zhedyaev, R. Y.; Ponomarev, I. I.; Vepkhvadze, T. F.; Zgoda, V. G.; Orlova, M. A.; Vavilov, N. E.; Shishkin, N. V.; Lednev, E. M.; Makhnovskii, P. A.; Sharlo, K. A.; Babkova, A. R.; Vassilieva, G. Y.; Gimadiev, R. R.; Shenkman, B. S.; Rukavishnikov, I. V.; Orlov, O. I.; Tomilovskaya, E. S.; Popov, D. V.
10.1101/2024.09.18.613609 — physiology — Posted on 2025-02-20
1692 FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Masalmeh, R. H. A.; Dawson, J. C.; Garcia, V. A.; Muir, M. T.; Carter, R. N.; Hardingham, G.; Davies, C.; Graham, R.; von Kriegsheim, A.; Marques Junior, J.; Pednekar, C.; Pollard, S. M.; Carragher, N. O.; Brunton, V. G.; Frame, M. C.
10.1101/2024.12.11.627900 — cancer biology — Posted on 2025-02-20
1695 Enzymatic carbon-fluorine bond cleavage by human gut microbes
Probst, S. I.; Felder, F. D.; Poltorak, V.; Mewalal, R.; Blaby, I. K.; Robinson, S. L.
10.1101/2024.07.15.601322 — biochemistry — Posted on 2025-02-20
1697 The RecBC complex protects single-stranded DNA gaps during lesion bypass
Philippin, G.; Dupaigne, P.; Chrabaszcz, E.; Iturralde, M.; Modesti, M.; Le Cam, E.; Pages, V.; Laureti, L.
10.1101/2023.09.04.556180 — molecular biology — Posted on 2025-02-20
1700 Development of iPSC-Derived T Cells Targeting EGFR Neoantigens in Non-Small Cell Lung Cancer
Niizuma, K.; Nishimura, T.; Villanueva, J.; Amaya, L.; Fowler, J. L.; Isobe, T.; Nakauchi, Y.; Saavedra, B.; Xu, H.; Nakanishi, M.; Wilkinson, A. C.; Loh, K. M. C.; Shrager, J. B.; Nakauchi, H.
10.1101/2025.02.15.638388 — immunology — Posted on 2025-02-20
1705 Benchmarking long-read genome assemblers for three sequencing protocols and three agricultural species
Birbes, C.; Dreau, A.; Milan, D.; Iampietro, C.; Gaspin, C.; Donnadieu, C.; Zytnicki, M.; Klopp, C.
10.1101/2025.02.14.638238 — bioinformatics — Posted on 2025-02-20
1707 A multimodal dataset linking wide-field calcium imaging to behavior changes in mice during an operant lever-pull task
Kondo, M.; Sehara, K.; Harukuni, R.; Aoki, R.; Sugimoto, S.; Tanaka, Y. R.; Matsuzaki, M.; Nakae, K.
10.1101/2025.02.03.631599 — neuroscience — Posted on 2025-02-20
1708 Computation-through-Dynamics Benchmark: Simulated datasets and quality metrics for dynamical models of neural activity
Versteeg, C.; McCart, J. D.; Ostrow, M.; Zoltowski, D. M.; Washington, C. B.; Driscoll, L.; Codol, O.; Michaels, J. A.; Linderman, S. W.; Sussillo, D.; Pandarinath, C.
10.1101/2025.02.07.637062 — neuroscience — Posted on 2025-02-20
1710 Screening for links between behaviour and acute hyperthermia and hypoxia resistance in rainbow trout using isogenic lines
Lagarde, H.; LALLIAS, D.; Phocas, F.; Goardon, L.; Bideau, M.; Guyvarc'h, F.; Labbe, L.; Dupont-Nivet, M.; Cousin, X.
10.1101/2023.10.19.563047 — animal behavior and cognition — Posted on 2025-02-20
1714 The Neuropeptide Sulfakinin, a peripheral regulator of insect behavior switch between mating and foraging
Li, H.-F.; Dong, B.; Peng, Y.-Y.; Luo, H.-Y.; Ou, X.-L.; Ren, Z.-L.; Park, Y.; Wang, J.-J.; Jiang, H.
10.1101/2024.07.30.605941 — ecology — Posted on 2025-02-20
1716 Mapping the regulatory effects of common and rare non-coding variants across cellular and developmental contexts in the brain and heart
Marderstein, A. R.; Kundu, S.; Padhi, E. M.; Deshpande, S.; Wang, A.; Robb, E.; Sun, Y.; Yun, C. M.; Pomales-Matos, D.; Xie, Y.; Nachun, D.; Jessa, S.; Kundaje, A.; Montgomery, S. B.
10.1101/2025.02.18.638922 — genomics — Posted on 2025-02-20
1720 Enhanced Brain-Heart Connectivity as a Precursor of Reduced State Anxiety After Therapeutic Virtual Reality Immersion
Sezer, I.; Moreau, P.; El Sayed Hussein Jomaa, M.; Godefroy, V.; Batrancourt, B.; Levy, R.; Filipchuk, A.
10.1101/2024.11.28.625818 — neuroscience — Posted on 2025-02-20
1721 Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource
Han, X.; Li, P. H.; Wang, S.; Blakely, T.; Aggarwal, S.; Gopalani, B.; Sanchez, M.; Schalek, R.; Meirovitch, Y.; Lin, Z.; Berger, D.; Wu, Y.; Aly, F.; Bay, S.; Delatour, B.; Lafaye, P.; Pfister, H.; Wei, D.; Jain, V.; Ploegh, H.; Lichtman, J.
10.1101/2023.10.24.563674 — neuroscience — Posted on 2025-02-20
1724 Nonconscious processing of fearful and neutral faces modulates the N170
Bruchmann, M.; Schindler, S.; Breitwieser, P.; Tilly, L.; Boelte, J.; Dellert, T.; Straube, T.
10.1101/2025.01.30.635452 — neuroscience — Posted on 2025-02-20
1726 Functional specialisation of multisensory temporal integration in the mouse superior colliculus
Bianchini, G.; Razafindrahaba, I.; Moglie, M. J.; Konstantinou, G.; Cano-Ferrer, X.; Imbert, A.; Iacaruso, F.
10.1101/2025.02.11.637674 — neuroscience — Posted on 2025-02-20
1727 Changes in cortical beta power predict motor control flexibility, not vigor
Pierrieau, E.; Dussard, C.; Plantey-Veux, A.; Guerrini, C.; Lau, B.; Pillette, L.; George, N.; Jeunet-Kelway, C.
10.1101/2025.01.23.634491 — neuroscience — Posted on 2025-02-20
1728 From aerial drone to QTL: Leveraging next-generation phenotyping to reveal the genetics of color and height in field-grown Lactuca sativa
Dijkhuizen, R. F.; van Eijnatten, A. L.; Mehrem, S. L.; van den Bergh, E. S.; van Lieshout, J.; Spaninks, K.; Kaandorp, S.; Offringa, R.; Proveniers, M.; Van den Ackerveken, G.; Snoek, B. L.
10.1101/2024.11.07.622452 — plant biology — Posted on 2025-02-20
1730 Tks5 interactome reveals ER-associated machinery translation in invadosomes.
NORMAND, L.; BONNARD, B.; Sala, M.; DI-TOMMASO, S.; DOURTHE, C.; RAYMOND, A.-A.; DUPUY, J.-W.; MERCIER, L.; GOETZ, J. G.; MOREAU, V.; HENRIET, E.; SALTEL, F.
10.1101/2024.07.02.601728 — cancer biology — Posted on 2025-02-20
1731 CHOPOFF: symbolic alignments enable fast and sensitive CRISPR off-target detection
Labun, K.; Rio, O.; Tjeldnes, H.; Swirski, M.; Komisarczuk, A. Z.; Haapaniemi, E. M.; Valen, E.
10.1101/2025.01.06.603201 — bioinformatics — Posted on 2025-02-20
1732 Towards a standard benchmark for phenotype-driven variant and gene prioritisation algorithms: PhEval - Phenotypic inference Evaluation framework
Bridges, Y. S.; de Souza, V.; Cortes, K. G.; Haendel, M.; Harris, N. L.; Korn, D. R.; Marinakis, N. M.; Matentzoglu, N.; McLaughlin, J. A.; Mungall, C. J.; Odell, A. T.; Osumi-Sutherland, D. J.; Robinson, P. N.; Smedley, D.; Jacobsen, J. O.
10.1101/2024.06.13.598672 — bioinformatics — Posted on 2025-02-20
1733 Multi-scale machine learning model predicts muscle and functional disease progression in FSHD
Blemker, S. S.; Riem, L.; DuCharme, O.; Pinette, M.; Costanzo, K. E.; Weatherley, E.; Statland, J.; Tapscott, S. J.; Wang, L. H.; Shaw, D. W. W.; The Move+ Investigator Team, ; Song, X.; Leung, D.; Friedman, S.
10.1101/2025.02.19.639046 — bioengineering — Posted on 2025-02-20
1734 Behavioral sequences across multiple animal species in the wild share common structural features
Minasandra, P.; Grout, E. M.; Brock, K.; Crofoot, M. C.; Demartsev, V.; Gersick, A. S.; Hirsch, B. T.; Holekamp, K. E.; Johnson-Ulrich, L.; Nayak, A.; Ortega, J.; Roch, M. A.; Strauss, E. D.; Strandburg-Peshkin, A.
10.1101/2024.01.20.576411 — animal behavior and cognition — Posted on 2025-02-20
1735 Hi-C sequencing data from cortex of laboratory rats
Kim, P.; Ward, R. R.; Sharp, B. M.; Williams, R. W.; Chen, H.
10.1101/2025.02.09.636698 — genomics — Posted on 2025-02-20
1737 Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution
Uveira, J.; Donati, A.; Leria, M.; Lechable, M.; Lahaye, F.; Vesque, C.; Houliston, E.; Momose, T.
10.1101/2024.09.05.609312 — developmental biology — Posted on 2025-02-20
1738 Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease
Crnkovic, S.; Thekkekara Puthenparampil, H.; Mulch, S.; Biasin, V.; Radic, N.; Wilhelm, J.; Bartkuhn, M.; Bonyadi Rad, E.; Wawrzen, A.; Matzer, I.; Mitra, A.; Leib, R. D.; Nagy, B. M.; Sahu-Osen, A.; Valzano, F.; Bordag, N.; Evermann, M.; Hoetzenecker, K.; Olschewski, A.; Ljubojevic-Holzer, S.; Wygrecka, M.; Stenmark, K.; Marsh, L. M.; de Jesus Perez, V.; Kwapiszewska, G.
10.1101/2024.05.15.594343 — cell biology — Posted on 2025-02-20
1739 A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Zeeshan, M.; Blatov, I.; Yanase, R.; Ferguson, D. J. P.; Pashley, S. L.; Chahine, Z.; Botte, Y. Y.; Mishra, A.; Marche, B.; Bhanvadia, S.; Hair, M.; Batra, S.; Markus, R.; Brady, D.; Bottrill, A.; vaughan, s.; Botte, C. Y.; Le Roch, K. G.; Holder, A. A.; Tromer, E. C.; Tewari, R.
10.1101/2024.12.04.625416 — cell biology — Posted on 2025-02-20
1741 ABCF Protein-Mediated Resistance Shapes Bacterial Responses to antibiotics Based on their Type and Concentration
Koberska, M.; Vesela, L.; Novotna, M.; Mahor, D.; Mazumdar, A.; Pindakova, N.; Petravicius, P. O.; Pokorna, J.; Kamenik, Z.; Balikova Novotna, G.
10.1101/2025.02.10.637581 — microbiology — Posted on 2025-02-20
1747 ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism
Rodriguez, L.; Fiedler, L.; Zou, M.; Giannini, C.; Monzer, A.; Vladimirtsev, D.; Randuch, M.; Yu, Y.; Gelova, Z.; Verstraeten, I.; Hajny, J.; Chen, M.; Tan, S.; Hoermayer, L.; Li, L.; Marques-Bueno, M. M.; Quddoos, Z.; Molnar, G.; Xu, T.; Kulich, I.; Jaillais, Y.; Friml, J.
10.1101/2022.11.30.518503 — plant biology — Posted on 2025-02-20
1749 Developmental divergence in gene regulation among rapidly radiating cichlid species
Duenser, A.; Singh, P.; Ahi, E. P.; Durdevic, M.; Schaeffer, S.; Gallaun, J.; Gessl, W.; Seehausen, O.; Sturmbauer, C.
10.1101/2024.01.24.577063 — evolutionary biology — Posted on 2025-02-20
1751 Developing Interferon-β as a safe in-vivo experimental-medicine model of human inflammation.
Periche-Tomas, E.; Maclver, C.; Underwood, J.; Leach, H.; Bone, C.; Jones, S. A.; Szomolay, B.; Triantafilou, K.; Harrison, N. A.
10.1101/2025.02.18.638888 — immunology — Posted on 2025-02-20
1754 Structure-function relationships of mucociliary clearance in human and rat airways
Roth, D.; Sahin, A. T.; Ling, F.; Tepho, N.; Senger, C.; Quiroz, E.; Calvert, B.; van der Does, A.; Güney, T. G.; Glasl, S.; van Schadewijk, A.; von Schledorn, L.; Olmer, R.; Kanso, E.; Nawroth, J. C.; Ryan, A. L.
10.1101/2023.12.24.572054 — biophysics — Posted on 2025-02-20
1755 CAGEcleaner: reducing genomic redundancy in gene cluster mining
De Vrieze, L.; Biltjes, M.; Lukashevich, S.; Tsurumi, K.; Masschelein, J.
10.1101/2025.02.19.639057 — bioinformatics — Posted on 2025-02-20
1757 Functionalized Calcium Carbonate Microparticles in Ethyl Cellulose Films: A Vehicle for Sustained Amoxicillin Release for Medical Applications
Niga, P.; Sala, S.; Rissler, J.; Nyström, L.; Fureby, A.; Elofsson, U.; Roth, R.; Gane, P.; Schoelkopf, J.; Simone Sala, Jenny Rissler, Lina Nyström, Anna Fureby, Ulla Elofsson, Roger Roth, Patrick Gane,
10.1101/2025.02.19.639024 — bioengineering — Posted on 2025-02-20
1758 Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
Zhou, J.; Zhao, D.; Li, J.; Kong, D.; Li, X.; Zhang, R.; Liang, Y.; Gao, X.; Qian, Y.; Wang, D.; Chen, J.; Lai, L.; Han, Y.; Li, Z.
10.1101/2024.04.17.589933 — biochemistry — Posted on 2025-02-20
1761 Enrichment of halogenated organic compounds and their degrading microorganisms in the deepest ocean
Liu, R.; Wei, H.; Xu, Z.; Liu, Y.; Wang, Z.; He, J.; Luo, M.; Baltar, F.; Xu, Y.; Liang, Q.; Huang, L.; Wang, L.; Fang, J.
10.1101/2025.02.11.637578 — microbiology — Posted on 2025-02-20
1763 Intracellular Trafficking SNARE Protein, Syntaxin-6, is a Modifier of Prion and Tau Pathogenesis in vivo and in Cellular Models
Hill, E.; Patel, M.; Ribes, J. M.; Linehan, J.; Zhang, F.; Farmer, M.; Jakubcova, T.; Hamdan, S.; Tomlinson, A.; Ercolani, T.; Schmidt, C.; Ahmed, P.; Thirlway, G.; Purro, S.; Argentina, F.; Marinho, A. T.; Jones, E. L.; Kaye, N.; Fitzhugh, C.; de Silva, R.; Jackson, G. S.; Brandner, S.; Kloehn, P.; Collinge, J.; Cunningham, T. J.; Mead, S.
10.1101/2025.02.19.635172 — neuroscience — Posted on 2025-02-20
1764 Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy
Li, H.; Xie, Z.; Tian, Y.; Lin, B.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Chen, S.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-02-20
1765 LONGITUDINAL CHANGES IN WHITE MATTERMICROSTRUCTURAL STATUS FOLLOWING QUANTIFIEDHEAD-BALL IMPACTS IN SOCCER: A PRELIMINARY,PROSPECTIVE STUDY.
McCloskey, H.; McNabb, C.; Laguna, P. L.; Keenan, B.; Evans, J.; Jones, D.; Palombo, M.; Barnes-Wood, M.; Adams, R.; Connelly, S.; Theobald, P.
10.1101/2025.02.14.637974 — bioengineering — Posted on 2025-02-20
1766 A method for authenticating the fidelity of Cryptococcus neoformans knockout collections
Jacobs, E.; Dragotakes, Q.; Kulkarni, M.; Dziedzic, A.; Jedlicka, A.; Hardwick, J. M.; Casadevall, A.
10.1101/2024.12.03.626716 — microbiology — Posted on 2025-02-20
1769 Transcriptional shifts and microbiome dynamics in sorghum roots during vegetative growth under drought stress
Kabir, A. H.; Brailey-Crane, P.; Abdelrahman, M.; Legeay, J.; Ahmed, B.; Tran, L.-S. P.; Bennetzen, J. L.
10.1101/2024.07.19.604343 — plant biology — Posted on 2025-02-20
1770 Chemotherapeutic 6-thio-2-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Sanford, S. L.; Badstubner, M.; Gerber, M.; Mannherz, W.; Lampl, N.; Dannenberg, R.; Hinchie, A.; Schaich, M. K.; Myong, S.; Hedglin, M.; Agarwal, S.; Alder, J. K.; Stone, M.; Opresko, P. L.
10.1101/2025.02.05.636339 — cancer biology — Posted on 2025-02-19
1771 Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components
Kshirsagar, A.; Mnatsakanyan, H.; Kulkarni, S.; Guo, J.; Cheng, K.; Bohra, O.; Sagar, R.; MACHAIRAKI, V.; Badr, C. E.; Kathuria, A.
10.1101/2025.01.20.633788 — bioengineering — Posted on 2025-02-19
1772 Polymeric Micellar Nanoparticles Enable Image-guided Drug Delivery in Solid Tumors
Uddin, M. J.; Lo, J. H.; Gupta, M. K.; Werfel, T. A.; Asaduzzaman, A.; Oltman, C. G.; Gbur, E. F.; mohyuddin, m. T.; nazmin, f.; Rahman, M. S.; Jashim, A.; Crews, B. C.; kingsley, p. J.; Marnett, L. J.; Duvall, C. L.; Cook, R. S.
10.1101/2024.06.07.598019 — bioengineering — Posted on 2025-02-19
1773 Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15
Davidson, J.; Jain, R.; Kizzar, T.; Geoghegan, G.; Nesbitt, D. J.; Cavanagh, A. T.; Abe, A.; Hunger, A.; Chao, X.; James, I.; Baldwin, D.; Verma, R.; Schueler, K. L.; Hinkoka-Galcheva, V.; Michorowska, S.; Shishkova, E.; Ding, W.-X.; Coon, J. J.; Shayman, J.; Simcox, J.
10.1101/2023.11.03.565498 — biochemistry — Posted on 2025-02-20
1774 Guided Differentiation of Pluripotent Stem Cells for Cardiac Cell Diversity
McIntire, E.; Barr, K. A.; Gonzales, N. M.; Allen, O. L.; Gilad, Y.
10.1101/2023.07.21.550072 — genomics — Posted on 2025-02-20
1775 Identification of functional non-coding variants associated with orofacial cleft
Kumari, P.; Friedman, R. Z.; Pi, L.; Curtis, S. W.; Paraiso, K.; Visel, A.; Rhea, L.; Dunnwald, M.; Patni, A. P.; Mar, D.; Bomsztyk, K.; Mathieu, J.; Ruohola-Baker, H.; Leslie, E. J.; White, M. A.; Cohen, B. A.; Cornell, R. A.
10.1101/2024.06.01.596914 — genetics — Posted on 2025-02-20
1777 Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing
Keenen, M. M.; Yang, L.; Liang, H.; Farmer, V. J.; Worota, R. E.; Singh, R.; Gladfelter, A. S.; Coyne, C. B.
10.1101/2024.07.01.601571 — developmental biology — Posted on 2025-02-20
1778 Molecular organization of the distal tip of vertebrate motile cilia
Hong, J.; Lee, C.; Papoulas, O.; Pan, J.; Takagishi, M.; Manzi, N.; Dickinson, D.; Horani, A.; Brody, S.; Marcotte, E.; Park, T. J.; Wallingford, J. B.
10.1101/2025.02.19.639145 — cell biology — Posted on 2025-02-19
1779 PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease
Nyame, K.; Xiong, J.; de Jong, A.; Alsohybe, H. N.; Raaben, M.; Hartmann, G.; Simcox, J. A.; Blomen, V.; Abu-Remaileh, M.; Pena, I. V.; de Miguel, R.; Brummelkamp, T. R.; Nijman, S. M. B.
10.1101/2024.06.07.597919 — cell biology — Posted on 2025-02-20
1780 Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation
Oksanen, M.; Mastropasqua, F.; Mazan-Mamczarz, K.; Martindale, J. L.; Ye, X.; Arora, A.; Banskota, N.; Gorospe, M.; Tammimies, K.
10.1101/2025.02.19.638869 — molecular biology — Posted on 2025-02-19
1782 Computational modelling reveals slower safety learning and threat extinction are associated with higher anxiety severity in remote fear conditioning
Kerr, T.; Purves, K.; McGregor, T.; Craske, M. G.; Barry, T.; Lester, K. J.; Constantinou, E.; Sun, M.; Robinson, O. J.; Eley, T. C.
10.1101/2025.02.18.638846 — neuroscience — Posted on 2025-02-19
1783 A single-cell transcriptomic atlas of developing inhibitory neurons reveals expanding and contracting modes of diversification.
Micoli, E.; Ferrero Restelli, F.; Barbiera, G.; Moors, R.; Nouboers, E.; Du, J. X.; Bertels, H.; Liu, M.; Konstantopoulos, D.; Takeoka, A.; Lippi, G.; Lim, L.
10.1101/2025.02.19.636192 — neuroscience — Posted on 2025-02-19
1785 Human newborns form musical predictions based on rhythmic but not melodic structure
Bianco, R.; Toth, B.; Bigand, F.; Nguyen, T.; Haden, G. P.; Sziller, I.; Winkler, I.; Novembre, G.
10.1101/2025.02.19.639016 — neuroscience — Posted on 2025-02-19
1788 Altered reactivity to threatening stimuli in Drosophila models of Parkinson's disease, revealed by a trial-based assay
Kajtor, M.; Billes, V. A.; Kiraly, B.; Karkusova, P.; Kovacs, T.; Stabb, H.; Sviatko, K.; Vizi, A.; Ujvari, E.; Balazsfi, D.; Seidenbecher, S. E.; Kvitsiani, D.; Vellai, T.; Hangya, B.
10.1101/2023.08.29.555311 — neuroscience — Posted on 2025-02-19
1790 Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade
Moore, J.; Gkantalis, J.; Guix, I.; Chou, W.; Yuen, K.; Lazar, A.; Spitzer, M. H.; Combes, A.; Barcellos-Hoff, M. H.
10.1101/2024.03.06.583752 — cancer biology — Posted on 2025-02-19
1793 The Structure of the Drp1 Lattice on Membrane
Peng, R.; Rochon, K.; Hutson, A. N.; Stagg, S.; Mears, J. A.
10.1101/2024.04.04.588123 — biochemistry — Posted on 2025-02-19
1794 Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
Lemee, M. V.; Loviglio, M. N.; Ye, T.; Tilly, P.; Keime, C.; Weber, C.; Petrova, A.; Klein, P.; Morlet, B.; Wendling, O.; Jacobs, H.; Tharreau, M.; Genevieve, D.; Godin, J. D.; Romier, C.; Duteil, D.; Golzio, C.
10.1101/2025.02.18.638841 — genomics — Posted on 2025-02-19
1795 Drivers of avian genomic change revealed by evolutionary rate decomposition
Duchene, D. A.; Chowdhury, A.-A.; Yang, J. A.; Iglesias-Carrasco, M.; Stiller, J.; Feng, S.; Gilbert, M. T. P.; Zhang, G.; Tobias, J.; Ho, S.
10.1101/2025.02.19.638997 — evolutionary biology — Posted on 2025-02-19
1796 Septin Organization is Regulated by the Gpa1 Ubiquitination Domain and Endocytic Machinery During the Yeast Pheromone Response.
Johnson, C. P.; Shrestha, S.; Hart, A.; Jarvis, K. F.; Genrich, L. E.; Latario, S. G.; Leclerc, N.; Geohegan, R. P.; Scandura, M.; Systuk, T.; Khalil, A.; Kelley, J. B.
10.1101/2023.06.16.545321 — cell biology — Posted on 2025-02-19
1797 Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers
Fettweis, G.; Wagh, K.; Stavreva, D. A.; Jimenez-Panizo, A.; Kim, S.; Lion, M.; Alegre-Marti, A.; Rinaldi, L.; Johnson, T. A.; Krishnamurthy, M.; Wang, L.; Ball, D. A.; Karpova, T. S.; Upadhyaya, A.; Vertommen, D.; Fernandez-Recio, J.; Estebanez-Perpina, E.; Dequiedt, F.; Hager, G. L.
10.1101/2024.12.09.627537 — molecular biology — Posted on 2025-02-19
1798 Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal
Gray, C. N.; Ashokkumar, M.; Janssens, D. H.; Kirchherr, J. L.; Allard, B.; Hsieh, E.; Hafer, T. L.; Archin, N. M.; Browne, E. P.; Emerman, M.
10.1101/2024.08.30.610517 — microbiology — Posted on 2025-02-19
1799 Decoding memory dysfunction in hippocampal amnesia
Miller, T. D.; Hickling, A. L.; Wu, Y. I.; Zhou, J. H.; Handel, A. E.; Coutinho, E.; Pollak, T. A.; Zandi, M. S.; Rosenthal, C. R.; Maguire, E. A.
10.1101/2025.02.19.638996 — neuroscience — Posted on 2025-02-19
1800 On the typical development of the central sulcus in infancy: a longitudinal evaluation of its morphology and link to behaviour
Dornier, A.; Gerard, A.; Leprince, Y.; Hertz-Pannier, L.; Mangin, J.-F.; Barbu-Roth, M.; Dubois, J.; Muret, D.
10.1101/2025.02.19.639011 — neuroscience — Posted on 2025-02-19
1801 Prior expectations guide multisensory integration during face-to-face communication
Mazzi, G.; Ferrari, A.; Mencaroni, M. L.; Valzolgher, C.; Tommasini, M.; Pavani, F.; Benetti, S.
10.1101/2025.02.19.638980 — neuroscience — Posted on 2025-02-19
1803 Neurochemical markers of uncertainty processing in humans
Jassim, N.; Waade, P. T.; Parsons, O.; Petzschner, F. H.; Rua, C.; Rodgers, C. T.; Baron-Cohen, S.; Suckling, J.; Mathys, C.; Lawson, R. P.
10.1101/2025.02.19.639013 — neuroscience — Posted on 2025-02-19
1805 Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer's and Parkinson's disease
Bhattacharya, A.; Fon, E. A.; Dagher, A.; Iturria-Medina, Y.; STRATTON, J. A.; Savignac, C.; Stanley, J.; Hodgson, L.; Hammou, B. A.; Bennett, D. A.; Bzdok, D.
10.1101/2025.02.17.638647 — neuroscience — Posted on 2025-02-19
1806 Histone Lysine Crotonylation Regulates Long-Term Memory Storage
Mukherjee, U.; Basu, B.; Beyer, S. E.; Ghodsi, S.; Robillard, N.; Vanrobaeys, Y.; Taylor, E. B.; Abel, T.; Chatterjee, S.
10.1101/2025.02.19.639114 — neuroscience — Posted on 2025-02-19
1809 Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development
Xu, X.; Lin, H.; Zhang, J.; Burguener, G.; Paraiso, F.; Tumelty, C.; Li, C.; Liu, Y.; Dubcovsky, J.
10.1101/2025.02.15.638402 — plant biology — Posted on 2025-02-19
1811 Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163
Huang, C.-S.; Wang, H.; White, J. B. R.; Degtjarik, O.; Huynh, C.; Brannstrom, K.; Horn, M. T.; Muench, S. P.; Somers, W. S.; Chaparro-Riggers, J.; Lin, L.; Mosyak, L.
10.1101/2025.02.14.638171 — biophysics — Posted on 2025-02-19
1813 High Dimensional Proteomic Multiplex Imaging of the Central Nervous System Using the COMET(TM) System
Najem, H.; Pacheco, S.; Turunen, J.; Tripathi, S.; Steffens, A.; McCortney, K.; Walshon, J.; Chandler, J.; Stupp, R.; Lesniak, M. S.; Horbinski, C. M.; Winkowski, D.; Kowal, J.; Burks, J. K.; Heimberger, A. B.
10.1101/2025.02.14.638299 — bioinformatics — Posted on 2025-02-19
1816 PDBCleanV2: A Python Library for Generating Consistent Structure Datasets
Pardo-Avila, F.; Weiner, L.; Cabral, P.; Corsepius, N. C.; Poitevin, F.; Levitt, M.
10.1101/2025.02.14.638326 — bioinformatics — Posted on 2025-02-19
1820 The mutational and clonality profile of HGSOC is established early in tumor development and conserved throughout therapy resistance
Diaz, M.; Gull, N.; Peng, P.-C.; Dabke, K.; Baker, J.; Sun, J.; Alvarado, J.; Bastin, B.; Mazumdar, N.; Santiskulvong, C.; Li, A. J.; Karlan, B. Y.; Rimel, B.; Parker, S. J.; Gayther, S. A.; Jones, M. R.
10.1101/2025.02.14.638365 — genomics — Posted on 2025-02-19
1821 AI mirrors experimental science to uncover a novel mechanism of gene transfer crucial to bacterial evolution
Penades, J. R.; Gottweis, J.; He, L.; Patkowski, J. B.; Shurick, A.; Weng, W.-H.; Tu, T.; Palepu, A.; Myaskovsky, A.; Pawlosky, A.; Natarajan, V.; Karthikesalingam, A.; Costa, T. R. D.
10.1101/2025.02.19.639094 — microbiology — Posted on 2025-02-19
1822 Design, development, and evaluation of gene therapeutics specific to KSHV-associated diseases
Inagaki, T.; Espera, J. M.; Wang, K.-H.; Komaki, S.; Nair, S.; Davis, R. R.; Kumar, A.; Nakajima, K.-i.; Izumiya, Y.
10.1101/2025.02.19.639178 — microbiology — Posted on 2025-02-19
1823 Investigating Facial Expression Processing during Fast Periodic Visual Stimulation using Highly Variable Stimuli
Vandenheever, D.; Davidson, H.; Kemp, J.; Murphy, Z.; Kujawa, A.; Shi, C.; Nadorff, M.; Bates-Brantley, K.; Sidwell, M.
10.1101/2025.02.14.638300 — neuroscience — Posted on 2025-02-19
1824 A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking
Montemarano, A.; Fox, L. D.; Alkhaleel, F. A.; Ostman, A. E.; Sohail, H.; Pandey, S.; Fox, M. E.
10.1101/2025.02.14.638324 — neuroscience — Posted on 2025-02-19
1825 Ultradeep N-glycoproteome Atlas of Mouse Reveals Spatiotemporal Signatures of Brain Aging and Neurodegenerative Diseases
Fang, P.; Yu, X.; ding, m.; Cong, Q.; Jiang, H.; Shi, Q.; Zhao, W.; Zheng, W.; Li, Y.; Ling, Z.; Kong, W.; Yang, P.; Shen, H.
10.1101/2025.02.15.638397 — neuroscience — Posted on 2025-02-19
1826 A Syntenic Pangenome for Gardnerella Reveals Taxonomic Boundaries and Stratification of Metabolic and Virulence Potential across Species
Bouzek, H.; Srinivasan, S.; Jones, D. S.; McMahon, E. F.; Strenk, S. M.; Fiedler, T. L.; Fredricks, D. N.; Johnston, C. D.
10.1101/2025.02.19.636902 — microbiology — Posted on 2025-02-19
1829 Transposons and accessory genes drive adaptation in a clonally evolving fungal pathogen
Lopez Diaz, C.; Ayhan, D. H.; Rodriguez Lopez, A.; Gomez Gil, L.; Ma, L.-J.; Di Pietro, A.
10.1101/2025.02.18.635021 — microbiology — Posted on 2025-02-19
1830 Oral Cavity Serves as Long-Term COVID-19 Reservoir with Increased Periodontal and Viral Disease Risk
Schwartz, J.; Capistrano, K.; Naqvi, R.; Elshourbagy, S.; Hezarkhani, A.; Etminan, S.; Bland, J.; Kadkol, S.; Shukla, D.; Nares, S.; Tomar, S.; Naqvi, A.
10.1101/2025.02.17.638734 — microbiology — Posted on 2025-02-19
1832 A novel Leishmania infantum reference strain for gene editing and the study of visceral leishmaniasis
THIAM, R.; Santana Ceballos, M.; BENEKE, T.; KUK, N.; PASQUIER, G.; CROBU, L.; JEFFARES, D.; VERGNES, B.; BARCKMANN, B.; Sterkers, Y.
10.1101/2025.02.18.638795 — microbiology — Posted on 2025-02-19
1833 Likely circulation of a coronavirus in roe deer (Capreolus capreolus) populations suggested by SARS-CoV-2 serological investigation in France
Perez, G.; Lalande, L. D.; Legros, V.; Kodjo, A.; Verheyden, H.; Bourret, V.; Cebe, N.; Chaval, Y.; Revelli, P.; Pellerin, M.; Lemaitre, J.-F.; Peroz, C.; Rey, B.; Debias, F.; Garcia, R.; Bourgoin, G.; Gilot-Fromont, E.
10.1101/2025.02.19.639030 — immunology — Posted on 2025-02-19
1834 Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
Sauter, K. A.; Webb, G. M.; Bader, L.; Kreklywich, C. N.; Takahashi, D. L.; Zaro, C.; McGuire, C. M.; Lewis, A. D.; Colgin, L. M. A.; Kirigiti, M. A.; Blomenkamp, H.; Pessoa, C.; Humkey, M.; Hulahan, J.; Sleeman, M.; Zweig, R. C.; Thomas, S.; Thomas, A.; Gao, L.; Hirsch, A. J.; Levy, M.; Cherry, S. R.; Kahn, S. E.; Slifka, M. K.; Sacha, J. B.; Kievit, P.; Roberts, C.
10.1101/2025.02.18.638792 — pathology — Posted on 2025-02-19
1835 In Vivo Production of a Protein via the Delivery of Plasmid DNA by Computationally Designed Polymer Nanoparticles (PNP)
Fisher, J. D.; Petersen, S. R.; Heynes, O.; Patil, S.; Tamayo-Mendoza, T.; Oviedo, F.; Guzman, G.; Van Reet, J.; Ting, J.; Kevlahan, S. H.; Neenan, T. X.; Murthy, S. K.
10.1101/2025.02.14.638338 — bioengineering — Posted on 2025-02-19
1836 Influenza A Virus Interferes With Respiratory Syncytial Virus in Mice and Reconstituted Human Airway Epithelium
Gilbert-Girard, S.; Piret, J.; Rheaume, C.; Carbonneau, J.; Goyette, N.; Couture, C.; Boivin, G.
10.1101/2025.02.19.639117 — microbiology — Posted on 2025-02-19
1837 Evolutionary and structural basis of SLAM utilization in morbilliviruses - Its implications for host range and cross-species transmission
Hyodo, A.; Seki, F.; Fukuda, K.; Tashiro, K.; Kitai, Y.; Akahori, Y.; Watabe, H.; Katoh, H.; Osaki, R.; Takaya, D.; Kawashita, N.; Fukuhara, H.; Ikegame, S.; Yoshikawa, T.; Eunsil, P.; Morikawa, S.; Yamaguchi, R.; Lee, B.; Maenaka, K.; Shirai, T.; Fukuzawa, K.; Tanaka, S.; Takeda, M.
10.1101/2025.02.18.638793 — microbiology — Posted on 2025-02-19
1838 Metabolically flexible microorganisms rapidly establish glacial foreland ecosystems
Ricci, F.; Bay, S. K.; Nauer, P.; Wong, W. W.; Ni, G.; Jimenez, L.; Jirapanjawat, T.; Leung, P. M.; Bradley, J. A.; Eate, V. M.; Hall, M.; Stubbusch, A.; Fernandez-Marin, B.; de los Rios, A.; Cook, P. L.; Schroth, M. H.; Chiri, E.; Greening, C.
10.1101/2025.02.19.639150 — microbiology — Posted on 2025-02-19
1840 ACE2 utilization of HKU25 clade MERS-related coronaviruses with broad geographic distribution
Liu, C.; Park, Y.-J.; Ma, C.-B.; Stuart, C.; Gen, R.; Sun, Y.-C.; Yang, X.; Lin, M.-Y.; Xiong, Q.; Si, J.-Y.; Liu, P.; Veesler, D.; Yan, H.
10.1101/2025.02.19.639017 — microbiology — Posted on 2025-02-19
1841 Evolution of BA.2.86 to JN.1 reveals functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2
Tsujino, S.; Tsuda, M.; Nao, N.; Okumura, K.; Wang, L.; Oda, Y.; Mimura, Y.; Li, J.; Hashimoto, R.; Matsumura, Y.; Suzuki, R.; Suzuki, S.; Yoshimatsu, K.; Nagao, M.; Ito, J.; Takayama, K.; Sato, K.; Matsuno, K.; Tamura, T.; Tanaka, S.; Fukuhara, T.
10.1101/2025.02.17.638623 — microbiology — Posted on 2025-02-19
1844 Year-round rhythms: alpine plant species modulate soil and microbial dynamics during the growing season and under the snow.
Ruka, A. T.; Schweichhart, J.; Dolezal, J.; Capkova, K.; Chlumska, Z.; Calvillo-Medina, R. P.; Meador, T. B.; Praeg, N.; Illmer, P.; Angel, R.; Rehakova, K.
10.1101/2025.02.18.638831 — microbiology — Posted on 2025-02-19
1846 A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli
Hernandez-Rocamora, V.; Martorana, A.; Belloso, A.; Ballesteros, D.; Zaccaria, M.; Perez, A.; Iorga, B.; Abia, D.; Gray, J.; Breukink, E.; Xiao, J.; Pazos, M.; Polissi, A.; Vollmer, W.
10.1101/2025.02.18.638797 — microbiology — Posted on 2025-02-19
1849 Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus
Izquierdo-Martinez, A.; Schaeper, S.; Brito, A. D.; Liao, Q.; Tesseur, C.; Sorg, M.; Botinas, D. S.; Wang, X.; Pinho, M. G.
10.1101/2025.02.18.638847 — microbiology — Posted on 2025-02-19
1850 Galleria mellonella model for studying Gram-positive bacterial implant biofilms
Mirza, K. A.; Nietzsche, S.; Tchatchiashvili, T.; Makarewicz, O.; Pletz, M.; Thieme, L.
10.1101/2025.02.18.638826 — microbiology — Posted on 2025-02-19
1851 Membrane vesicles of Shewanella oneidensis MR-1 enhance denitrification growth in a species-selective manner
Takahashi, K.; Takeda, R.; Savage, T. K.; Kataoka, M.; Yamamoto, T.; Okabe, S.; Nomura, N.; Oshiki, M.; Toyofuku, M.; Tokunou, Y.
10.1101/2025.02.19.636751 — microbiology — Posted on 2025-02-19
1853 Disassembly of the Escherichia coli AcrABZ-TolC efflux pump by ligand-mediated disruption of TolC-AcrA interfacial contacts
Szal, T.; Petsolari, E.; Veliks, J.; Cruz, C. D.; Paunina, L.; Madre, M.; Rachad, F.-Z.; Lewe, P.; Witt, S.; Tammela, P.; Jirgensons, A.; Luisi, B. F.; Windshügel, B.
10.1101/2025.02.18.638599 — microbiology — Posted on 2025-02-19
1854 Measurement Quality Metrics to Improve Absolute Microbial Cell Counting
Parratt, K.; Newton, D.; Dunkers, J. P.; Dootz, J. N.; Hunter, M. E.; Logan, A.; Pierce, L.; Sarkar, S.; Servetas, S. L.; Lin, N.
10.1101/2025.02.18.638308 — microbiology — Posted on 2025-02-19
1855 The small GTPase Rab5 inhibits actin polymerization mediated by the Legionella pneumophila effector VipA
Saraiva, J.; Bugalhao, J. N.; Carvalho, T.; Hensel, Z.; Crevenna, A.; Mota, L. J.; Franco, I. S.
10.1101/2025.02.18.638817 — microbiology — Posted on 2025-02-19
1858 Cholesterol efflux protein, ABCA1, supports anti-cancer functions of myeloid immune cells
Bendre, S. V.; Wang, Y.; Hajyousif, B.; K C, R.; Bhogale, S. G.; Pradeep, D.; Krawczynska, N.; Schane, C. P.; Weisser, E.; Singh, A.; Han, S.; Kim, H.; Kockaya, L.; Das Gupta, A.; Nelczyk, A. T.; Gamage, H. E. V.; Fei, Y.; Guo, X.; Deaton, R. J.; Sverdloc, M.; Gann, P. H.; Sinha, S.; Wang, K.; Van Bortle, K. T.; Tajkhorshid, E.; Cho, W.; Nelson, E. R.
10.1101/2025.02.19.638515 — cancer biology — Posted on 2025-02-19
1863 Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas
Lee, M. Y. Y.; Guessoum, O.; El-Mekkoussi, H.; Conery, M.; Manduchi, E.; Schug, J.; Descamp, H.; Lahori, D.; Da, T.; Liu, C.; Naji, A.; Voight, B.; Li, M.; Kaestner, K. H.
10.1101/2025.02.14.638309 — systems biology — Posted on 2025-02-19
1865 Regulation of lipid dysmetabolism and neuroinflammation linked with Alzheimer's disease through modulation of Dgat2
Yadav, A.; Ouyang, O.; Barkley, M.; Watson, J.; Madamanchi, K.; Kramer, J.; Zhang, J.; Melkani, G. C.
10.1101/2025.02.18.638929 — physiology — Posted on 2025-02-19
1868 The Structure of the Drp1 Lattice on Membrane
Peng, R.; Rochon, K.; Hutson, A. N.; Stagg, S.; Mears, J. A.
10.1101/2024.04.04.588123 — biochemistry — Posted on 2025-02-19
1869 Real-time genomic characterization of pediatric acute leukemia using adaptive sampling
Geyer, J.; Opoku, K. B.; Lin, J.; Ramkissoon, L.; Mullighan, C.; Bhakta, N.; Alexander, T. B.; Wang, J. R.
10.1101/2024.10.11.617690 — genomics — Posted on 2025-02-19
1872 The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
Leone, M.; Eichin, F.; Kinz, N.; Obwegs, D.; Sladky, V. C.; Rizzotto, D.; Manzl, C.; Moos, K.; Mergner, J.; Savko, C.; Giansanti, P.; Garcia, N. M.; Marques, M. M.; Jacotot, E. D.; Boerries, M.; Sussman, M.; Villunger, A.
10.1101/2024.08.27.609375 — developmental biology — Posted on 2025-02-19
1873 Hoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis
Dziurdzik, S. K.; Sridhar, V.; Eng, H.; Neuman, S. D.; Yan, J.; Davey, M.; Taubert, S.; Bashirullah, A.; Conibear, E.
10.1101/2025.02.11.637747 — cell biology — Posted on 2025-02-19
1875 Broadband visual stimuli improve neuronal representation and sensory perception
Balla, E.; Nabbefeld, G.; Wiesbrock, C.; Linde, J.; Graff, S.; Musall, S.; Kampa, B.
10.1101/2023.05.03.539238 — neuroscience — Posted on 2025-02-19
1879 The architecture, assembly, and evolution of a complex flagellar motor
Feng, X.; Tachiyama, S.; He, J.; Zhu, S.; Zhao, H.; Botting, J. M.; Liu, Y.; Chen, Y.; Hua, C.; Lara-Tejero, M.; Baker, M. A.; Gao, X.; Liu, J.; Gao, B.
10.1101/2025.02.19.638559 — microbiology — Posted on 2025-02-19
1880 Toxoplasma in a natural population of chimpanzees
Chabry, M.; Zuberbuehler, K.; Koella, J.; Hobaiter, C.
10.1101/2025.02.18.638806 — zoology — Posted on 2025-02-19
1881 Remote sensing reveals inter- and intraspecific variation in riparian cottonwood (Populus spp) response to drought
Seeley, M.; Wiebe, B. C.; Gehring, C. A.; Hultine, K.; Posch, B. C.; Cooper, H. F.; Schaefer, E. A.; Bock, B. M.; Abraham, A. J.; Moran, M. E.; Keith, A.; Allan, G. J.; Scull, M.; Whitham, T. G.; Martin, R. E.; Asner, G. P.; Doughty, C.
10.1101/2025.02.17.638728 — plant biology — Posted on 2025-02-19
1882 Structural and Functional Insights into GGCX-FIX Interaction: Implications for Vitamin K-Dependent Bleeding Disorders
Liu, K.; Li, S.; Tong, J.; Jiang, N.; Hong, M.; Gu, Y.; Chen, L.; Liang, D.; Jin, Y.; Zhao, Y.; Hou, D.; Huang, J.; Tie, J.-K.; Hao, Z.
10.1101/2025.02.18.638829 — pathology — Posted on 2025-02-19
1884 Explainable machine learning for health disparities: type 2 diabetes in the All of Us research program
Kambara, M. S.; Chukka, O.; Choi, K. J.; Tsenum, J.; Gupta, S.; English, N. J.; Jordan, I. K.; Marino-Ramirez, L.
10.1101/2025.02.18.638789 — bioinformatics — Posted on 2025-02-19
1886 Field Evidence of Trypanosoma cruzi Infection, Diverse Host Use and Invasion of Human Dwellings by the Chagas Disease Vector in Florida, USA
Beatty, N.; Bhosale, C. R.; White, Z. S.; Torhorst, C. W.; Wilson, K. N.; Dorleans, R.; Stenn, T. M. S.; Killets, K. C.; Curtis-Robles, R.; Burkett-Cadena, N.; Novakova, E.; Hamer, G. L.; Hamer, S. A.; Wisely, S. M.
10.1101/2025.02.18.638794 — ecology — Posted on 2025-02-19
1888 Endothelial decorin is increased by ageing and, induces inflammation and diastolic dysfunction in the heart
Luxan, G.; Winkelmeier, T.; Bodemer, C.; Togru, B. N.; Shumliakivska, M.; Muhly-Reinholz, M.; Fischer, A.; Ruz Jurado, M.; John, D.; Abplanalp, W. T.; Dimmeler, S.
10.1101/2025.02.14.638240 — physiology — Posted on 2025-02-19
1889 Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population
Westcott, G. P.; Emont, M. P.; Gulko, A.; Zhou, Z.; Kim, C.; Varma, G.; Tsai, L. L.; O'Donnell, E.; Yang Loureiro, Z.; Liang, W.; Jacobs, C.; Tsai, L. T.; Padera, T. P.; Singhal, D.; Rosen, E. D.
10.1101/2025.02.18.638907 — cell biology — Posted on 2025-02-19
1890 Genomic Insights into the Diversity, Antimicrobial Resistance, and Zoonotic Potential of Campylobacter fetus Across Diverse Hosts and Geographies
Paintsil, E. K.; Adu-Asiamah, C. K.; Boahen, K. G.; Akenten, C. W.; Kwarteng, A.; Berg, S.; Obiri-Danso, K.; May, J.; Dekker, D.; Ofori, L. A.
10.1101/2025.02.16.638542 — genomics — Posted on 2025-02-19
1892 Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria
Mukherjee, S. D.; Batagello, C.; Adler, A.; Agudelo, J.; Zampini, A.; Suryavanshi, M.; Nguyen, A.; Orr, T.; Dearing, D.; Monga, M.; Miller, A. W.
10.1101/2024.10.28.620613 — microbiology — Posted on 2025-02-19
1893 Deep Learning-based Framework for Mycobacterium tuberculosis Bacterial Growth Detection for Antimicrobial Susceptibility Testing
Vo, H.-A. T.; Nguyen, S.; Tran, A.-Q. T.; Nguyen, H.; Ho, H. B.; Fowler, P. W.; Walker, T. M.; Nguyen, T. T.
10.1101/2025.02.14.638231 — microbiology — Posted on 2025-02-19
1894 Stable Actin As Synaptic Tag
Thomas, M.; Bogaciu, C.-A.; Rizzoli, S.; Fauth, M.
10.1101/2025.02.10.637360 — neuroscience — Posted on 2025-02-19
1896 A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis
Jin, M.; Ogundare, S.; Lanio, M.; Sorid, S.; Whye, A. R.; Leal Santos, S.; Franceschini, A.; Denny, C. A.
10.1101/2024.07.12.603299 — neuroscience — Posted on 2025-02-19
1897 Influence of Gut Microbiota on Oral Drug Absorption and Metabolism
Nelson, D. A.; Veerareddy, V.; Kashyap, P. C.; Tang, X.; Kalari, K. R.; Kandimalla, K. K.
10.1101/2025.02.16.638186 — pharmacology and toxicology — Posted on 2025-02-19
1901 Fronto-motor circuits linked to effort-based decision-making and apathy in healthy subjects
Derosiere, G.; Vassiliadis, P.; Dricot, L.; Dessain, Q.; Delinte, N.; Zenon, A.; Duque, J.
10.1101/2024.10.07.616861 — neuroscience — Posted on 2025-02-19
1903 Mapping the regulatory effects of common and rare non-coding variants across cellular and developmental contexts in the brain and heart
Marderstein, A. R.; Kundu, S.; Padhi, E. M.; Deshpande, S.; Wang, A.; Robb, E.; Sun, Y.; Yun, C. M.; Pomales-Matos, D.; Xie, Y.; Nachun, D.; Jessa, S.; Kundaje, A.; Montgomery, S. B.
10.1101/2025.02.18.638922 — genomics — Posted on 2025-02-19
1904 Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health
Aranda-Diaz, A.; Vickers, E. N.; Murie, K.; Palmer, B.; Hathaway, N.; Gerlovina, I.; Boene, S.; Garcia-Ulloa, M.; Cistero, P.; Katairo, T.; Semakuba, F. D.; Nsengimaana, B.; Gwarinda, H.; Garcia-Fernandez, C.; Louie, W.; Esayas, E.; Da Silva, C.; Datta, D.; Kiyaga, S.; Wiringilimaana, I.; Fekele, S. M.; Bennett, A.; Smith, J. L.; Gadisa, E.; Parr, J. B.; Conrad, M.; Raman, J.; Tukwasibwe, S.; Ssewanyana, I.; Rovira-Vallbona, E.; Tato, C. M.; Briggs, J.; Mayor, A.; Greenhouse, B.
10.1101/2024.08.22.609145 — genomics — Posted on 2025-02-19
1907 The sequence and structural integrity of the SARS-CoV-2 Spike protein transmembrane domain is crucial for viral entry
Ortiz-Mateu, J.; Belda, D.; Aviles-Alia, A. I.; Alonso-Romero, J.; Garcia-Murria, M. J.; Mingarro, I.; Geller, R.; Martinez-Gil, L.
10.1101/2024.11.19.624333 — molecular biology — Posted on 2025-02-19
1908 A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor
Volkening, J. D.; Spatz, S. J.; Garcia, M.; Ross, T. A.; Maekawa, D. A.; Rosenthal, K. S.; Zamora, A. C.; Skipper, A.; Blakey, J.; Paudel, R.
10.1101/2024.07.10.602945 — microbiology — Posted on 2025-02-19
1909 Autism-associated ASPM variant causes macrocephaly and social-cognitive deficits in mice
Singh, S.; Kim, H.; Ecevitoglu, A.; Chasse, R.; Ludko, A. M.; Sanganahalli, B.; Gangasandra, V.; Park, S. R.; Yee, S.-P.; Grady, J.; Salamone, J.; Fitch, R. H.; Spellman, T.; Hyder, F.; Bae, B.-I.
10.1101/2025.02.17.638753 — neuroscience — Posted on 2025-02-19
1910 Chronic social defeat causes dysregulation of systemic glucose metabolism via the cerebellar fastigial nucleus
Ishimoto, T.; Abe, T.; Nakamura, Y.; Tsuyama, T.; Kondoh, K.; Kajitani, N.; Yoshida, K.; Takeuchi, Y.; Kato, K. X.; Xu, S.; Koduki, M.; Ichimura, M.; Itoi, T.; Shimba, K.; Yamaguchi, Y.; Minami, M.; Koike, S.; Kasai, K.; Ye, J. J.; Takebayashi, M.; Yamagata, K.; Toda, C.
10.1101/2025.02.18.638938 — neuroscience — Posted on 2025-02-19
1911 Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula
Kwon, M.; Bo, K.; Botvinik-Nezer, R.; Kragel, P. A.; Van Oudenhove, L.; Wager, T. D.; The Affective Neuroimaging Consortium,
10.1101/2025.02.18.638889 — neuroscience — Posted on 2025-02-19
1912 Microglia regulate neuronal activity via structural remodeling of astrocytes
Gu, N.; Makashova, O.; Laporte, C.; Chen, C. Q.; Li, B.; Chevillard, P.-M.; Lean, G.; Yang, J.; Wong, C.; Fan, J.; Sharif, B.; Saud, S. P.; Hubacek, M.; Choe, K. Y.; Khoutorsky, A.; Bourque, C. W.; Prager-Khoutorsky, M.
10.1101/2025.02.18.638874 — neuroscience — Posted on 2025-02-19
1914 Vasomotor Pulsation Becomes a Driver of Cerebrospinal Fluid and Electrophysiological Dynamics in Sleeping Human Brain
Väyrynen, T.; Tuunanen, J.; Helakari, H.; Elabasy, A.; Korhonen, V.; Huotari, N.; Piispala, J.; Kallio, M.; Nedergaard, M.; Kiviniemi, V.
10.1101/2024.10.16.618430 — neuroscience — Posted on 2025-02-19
1916 BabyPy: a brain-age model for infancy, childhood and adolescence
Biondo, F.; O'Muircheartaigh, J.; Bethlehem, R. A. I.; Seidlitz, J.; Alexander-Bloch, A.; Elison, J.; D'Sa, V.; Deoni, S. C. L.; Bruchhage, M. M. K.; Cole, J. H.
10.1101/2025.02.05.636598 — neuroscience — Posted on 2025-02-19
1917 Hydrogen Sulfide modulates Flagellin-Induced Stomatal Immunity
Scuffi, D.; Pantaleno, R.; Schiel, P.; Peer Niemeier, J.-O.; Costa, A.; Schwarzländer, M.; Laxalt, A.; Garcia Mata, C.
10.1101/2025.02.14.638267 — plant biology — Posted on 2025-02-19
1918 Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors
Schahl, A.; Lagardere, L.; Walker, B.; Ren, P.; Wioland, H.; Ballet, M.; JEGOU, A.; Chavent, M.; Piquemal, J.-P.
10.1101/2022.12.16.520803 — biophysics — Posted on 2025-02-19
1920 Neuromodulation in neural organoids with shell MEAs
Acha, C.; George, D.; Diaz, L. C.; Ouyang, Z.; Alam El Din, D.-M. M.; Surlekar, H.; Moghadas, B.; Rayasam, P. S. R.; Lai, Y.-C.; Smirnova, L.; Caffo, B. S.; Johnson, E. C.; Gracias, D. H.
10.1101/2025.02.18.637712 — bioengineering — Posted on 2025-02-19
1921 Refining Spatial Proteomics by Mass Spectrometry: An Efficient Workflow Tailored for Archival Tissue
Daucke, R.; Rift, C. V.; Bager, N. S.; Saxena, K.; Koffeldt, P. R.; Woessmann, J.; Petrosius, V.; Rugiu, E. S.; Kristensen, B. W.; Klausen, P.; Schoof, E. M.
10.1101/2024.01.25.577263 — bioengineering — Posted on 2025-02-19
1925 Dynamic early recruitment of GAK-Hsc70 regulates coated pit maturation
He, Z.; Zuo, P.; Xu, P.; Yuan, H.; Bhave, M.; Wei, X.; Yang, Z.; Han, L.; Schmid, S. L.; Chen, Z.
10.1101/2025.02.18.638964 — cell biology — Posted on 2025-02-19
1926 Quantification of SARM1 activity in human peripheral blood mononuclear cells
Dabill, L.; Shen, I.; Brazill, J.; Neiner, A.; Sasaki, Y.; Scheller, E. L.
10.1101/2025.02.17.638666 — cell biology — Posted on 2025-02-19
1929 CHIP protects lysosomes from CLN4 mutant-induced membrane damages
Lee, J.; Zou, J.; Mazli, W. N. A. B.; Chin, N.; Jarnik, M.; Saidi, L.; Xu, Y.; Replogle, J.; Ward, M.; Bonifacino, J.; Zheng, W.; Hao, L.; Ye, Y.
10.1101/2025.02.18.638932 — cell biology — Posted on 2025-02-19
1930 Membrane transporter Progressive Ankylosis Protein Homolog (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing.
James, E. N.; Teh, M.-T.; Li, Y.; Wagner-bock, C.; Al-Khateeb, Z. F.; Karen-Ng, L. P.; Roberts, T.; Synchyshyn, L.; Lewis, A.; O'Loghlen, A.; Silver, A.; Michael-Titus, A. T.; Bennett, M.; Bundy, J. G.; Mycielska, M. E.; Parkinson, E. K.
10.1101/2024.08.30.609895 — cell biology — Posted on 2025-02-19
1931 Harnessing the immune system to treat bone loss: The immunomodulatory and osteoprotective effects of the microalga Skeletonema costatum
Carletti, A.; Pes, K.; Tarasco, M.; Rosa, J. T.; Poudel, S.; Pereira, H.; Louro, B.; Cancela, M. L.; Laize, V.; Gavaia, P. J.
10.1101/2025.02.14.638280 — immunology — Posted on 2025-02-19
1933 Epigenetic changes, neuronal dysregulation and metabolomic abnormalities in Zmym2 mutant mice, a genetic model of schizophrenia and neurodevelopmental disorders
Huang, W.-C.; Mandell, K. P.; Aryal, S.; Song, B. J.; Valle-Tojeiro, A.; Goble, N.; Geng, C.; Asan, A. S.; Liu, X.-M.; Dennis, C.; Dailey, L.; Deik, A.; Inunciaga, L.; Mashin, E.; Farsi, Z.; Wang, Y.; Pan, J. Q.; Clish, C. B.; Keshishian, H.; Carr, S. A.; Sheng, M.
10.1101/2025.02.18.638656 — neuroscience — Posted on 2025-02-19
1938 Fructose-1,6-bisphosphatase (FBPase) fine-tunes heterotrophic growth in cyanobacteria
Caliebe, F.; Ojha, R. S.; Gruber, M.; Boehm, M.; Shen, L.; Bräsen, C.; Snoep, J. L.; Forchhammer, K.; Hagemann, M.; Siebers, B.; Gutekunst, K.
10.1101/2025.02.14.638281 — plant biology — Posted on 2025-02-19
1941 GerNA-Bind: Geometric-enhanced RNA-ligand Binding Specificity Prediction with Deep Learning
Xia, Y.; Li, J.; Chu, Y.-T.; Rao, J.; Chen, J.; Hua, C.; Yu, D.-J.; Chen, X.-C.; Zheng, S.
10.1101/2025.02.15.638393 — bioinformatics — Posted on 2025-02-19
1944 Integrative Analysis of Single-cell and Bulk RNA Sequencing Reveals Macrophage Heterogeneity in Lyme Arthritis
Zhou, G.; Chen, X.; Dong, Y.; Luo, Y.; Liu, M.; Chen, Y.; Song, C.; Liu, X.; Yang, F.; Liang, Z.; Zi, L.; Gao, H.; Cao, Z.; Gao, F.
10.1101/2025.02.14.638349 — genomics — Posted on 2025-02-19
1945 Genomic prediction of symbiotic interactions between two Endozoicomonas clades and their coral host, Acropora loripes
Gotze, C. R.; Tandon, K.; Philip, G. K.; Dungan, A. M.; Maire, J.; Hoj, L.; Blackall, L. L.; van Oppen, M. J.
10.1101/2025.02.16.638547 — genomics — Posted on 2025-02-19
1947 Efficient Inference of Macrophylogenies: Insights from the Avian Tree of Life
Zhao, M.; Thom, G.; Faircloth, B. C.; Andersen, M. J.; Barker, F. K.; Benz, B. W.; Braun, M. J.; Bravo, G. A.; Brumfield, R. T.; Chesser, R. T.; Derryberry, E. P.; Glenn, T. C.; Harvey, M. G.; Hosner, P. A.; Imfeld, T. S.; Joseph, L.; Manthey, J. D.; McCormack, J. E.; McCullough, J. M.; Moyle, R. G.; Oliveros, C. H.; Carreiro, N. D. W.; Winker, K.; Field, D. J.; Ksepka, D. T.; Braun, E. L.; Kimball, R. T.; Smith, B. T.
10.1101/2025.02.17.638170 — evolutionary biology — Posted on 2025-02-19
1949 Organo-metal coprecipitation contributes to stable organic carbon fraction in mangrove soil
Hamada, K.; Yimatsa, N.; Ohtsuka, T.; Fujitake, N.; Miyajima, T.; Yokoyama, Y.; Miyairi, Y.; Kida, M.
10.1101/2025.02.15.638410 — ecology — Posted on 2025-02-19
1950 IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency
Sullivan, O. M.; Nesbitt, D. J.; Schaack, G. A.; Feltman, E.; Nipper, T.; Kongsomros, S.; Reed, S. G.; Nelson, S. L.; King, C. R.; Shishkova, E.; Coon, J. J.; Mehle, A.
10.1101/2025.02.17.638785 — microbiology — Posted on 2025-02-19
1951 Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling
Tang, J.; Jia, X.; Zeng, T.; Bao, Y.; Hu, Y.; Dong, J.; Xu, X.; Chen, X. L.; Liu, Y.; Wang, J.; Hou, B.; Zhu, Y.; Fu, G.-F.; Zheng, Q.; Chen, Y.; Li, W.; Ren, T.; Zhang, L.; Jiang, S.; Cong, Y.; Quan, M.; Yan, C.; Lin, S.; Wang, N.; Liu, S.; Huang, C.; Hou, L.; Teijaro, J.; Brzostek, J.; Gautam, N.; Xiao, C.; Wang, Y.; Li, G.; Xu, B.; Hui, E.; Wang, H.-R.; Gascoigne, N. R. J.; Fu, G.
10.1101/2025.02.17.634430 — immunology — Posted on 2025-02-19
1952 Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
Sanchez-Martinez, E.; Rondeau, L. E.; Garrido-Romero, M.; Barbosa, B.; Haas, D. A.; Yuen, G.; Hall, P.; Dang, R.; Wang, X.-Y.; Moreno-Serna, L.; Lopez-Sanz, C.; Nunez-Borque, E.; Garrido-Arandia, M.; Diaz-Perales, A.; Carrasco, Y. R.; Koenig, J. F.; Walker, T. D.; Jordana, M.; Verdu, E. F.; Surette, M. G.; Ojeda, P.; Vega, F.; Blanco, C.; Shreffler, W. G.; Patil, S. U.; Moreno, F. J.; Jimenez-Saiz, R.; Caminero, A.
10.1101/2025.02.17.638013 — immunology — Posted on 2025-02-19
1953 Neutralizing antibodies elicited by Nipah virus G-head nanoparticle target diverse sites and inhibit receptor binding and fusion
Zhou, D.; Wang, Y.; Yao, Y.; Kuang, W.; Cheng, R.; Zhang, G.; Liu, H.; Li, X.; Chiu, S.; Deng, Z.; Zhao, H.
10.1101/2025.02.16.638571 — immunology — Posted on 2025-02-19
1957 X-ray Diffraction Reveals Periodicity in Murine Neocortex
Murokh, S.; Willerson, E. N.; Lazarev, A.; Lazarev, P.; Brumberg, J. C.
10.1101/2024.10.13.618071 — neuroscience — Posted on 2025-02-19
1958 NeuroDISK: An AI Approach to Automate Continuous Inquiry-Driven Discoveries in Neuroimaging Genetics
Garijo, D.; Yang, Q.; Vargas, H.; Gadewar, S. P.; Low, K.; Ratnakar, V.; Osorio, M.; Zhu, A. H.; McMahon, A.; Gil, Y.; Jahanshad, N.
10.1101/2025.02.14.638360 — bioinformatics — Posted on 2025-02-19
1961 Correlating High-dimensional longitudinal microbial features with time-varying outcomes with FLORAL
Fei, T.; Donovan, V.; Funnell, T.; Baichoo, M.; Waters, N. R.; Paredes, J.; Dai, A.; Castro, F.; Haber, J.; Gradissimo, A.; Raj, S. S.; Lesokhin, A. M.; Shah, U. A.; van ben Brink, M. R. M.; Peled, J.
10.1101/2025.02.17.638558 — bioinformatics — Posted on 2025-02-19
1963 Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships
Shevade, K.; Yang, Y. A.; Feng, K.; Mader, K.; Sevim, V.; Parsons, J.; Arora, G.; Elfawy, H.; Mace, R.; Federman, S.; Esanov, R.; Shafer, S.; Chow, E. D.; Przybyla, L.
10.1101/2025.02.11.637716 — genomics — Posted on 2025-02-19
1965 Evidence of an Allostatic Response by Intestinal Tissues Following Induction of Joint Inflammation
Moran, M. M.; Li, J.; Shen, Q.; Drummond, S. P.; Milner, C. M.; Day, A. J.; Naqib, A.; Sumner, D. R.; Plaas, A.
10.1101/2024.10.17.618923 — cell biology — Posted on 2025-02-19
1966 Fine root endophytes forming winter mycorrhiza
Sentoku, T.; Komatsuda, Y.; Shimada, H.; Arai, M.; Kobae, Y.
10.1101/2025.01.10.632310 — plant biology — Posted on 2025-02-18
1967 Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
Villani, F.; Sasani, T. A.; Maksimov, M.; Gunturkun, M. H.; Ma, N.; Ren, Y.-y.; Rothschild, D.; Chen, H.; Lu, L.; Dumont, B. L.; Harris, K.; Gymrek, M.; Colonna, V.; Pritchard, J. K.; Palmer, A. A.; Williams, R. W.; Ashbrook, D. G.
10.1101/2022.04.21.489063 — genomics — Posted on 2025-02-18
1968 Genomes of nitrogen-fixing eukaryotes reveal a non-canonical model of organellogenesis
Frail, S.; Steele-Ogus, M.; Doenier, J.; Moulin, S. L. Y.; Braukmann, T.; Xu, S.; Yeh, E.
10.1101/2024.08.27.609708 — evolutionary biology — Posted on 2025-02-18
1970 The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules
Gopal, D.; Wu, J.; Delaroche, J.; Bosc, C.; de Andrade, m.; Denarier, E.; Effantin, G.; Andrieux, A.; Gory-Faure, S.; serre, l.; Arnal, I.
10.1101/2025.02.17.638590 — cell biology — Posted on 2025-02-18
1971 Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI
Mandino, F.; Horien, C.; Shen, X.; Desrosier-Gregoire, G.; Luo, W.; Markicevic, M.; Constable, R. T.; Papademetris, X.; Chakravarty, M.; Betzel, R.; Lake, E. M.
10.1101/2024.05.24.594620 — neuroscience — Posted on 2025-02-18
1975 Labelizer: systematic selection of protein residues for covalent fluorophore labeling
Gebhardt, C.; Bawidamann, P.; Spring, A.-K.; Schenk, R.; Schuetze, K.; Moya Munoz, G. G.; Wendler, N.; Griffith, D.; Lipfert, J.; Cordes, T.
10.1101/2023.06.12.544586 — biophysics — Posted on 2025-02-18
1976 Optical sectioning for reflection interference microscopy
Ventalon, C.; Kirichuk, O.; Navon, Y.; Chastagnier, Y.; Heux, L.; Richter, R. P.; Bureau, L.; Debarre, D.
10.1101/2024.06.07.598038 — biophysics — Posted on 2025-02-18
1977 Three STEPs forward: A trio of unexpected structures of PTPN5
Guerrero, L.; Ebrahim, A.; Riley, B. T.; Kim, S. H.; Bishop, A. C.; Wu, J.; Han, Y. N.; Tautz, L.; Keedy, D. A.
10.1101/2024.11.20.624168 — biophysics — Posted on 2025-02-18
1979 Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy
Li, H.; Xie, Z.; Tian, Y.; Lin, B.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Chen, S.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-02-18
1983 Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum
Setogawa, S.; Okauchi, T.; Hu, D.; Wada, Y.; Hikishima, K.; Onoe, H.; Nishizawa, K.; Sakayori, N.; Miyawaki, H.; Kitanishi, T.; Mizuseki, K.; Cui, Y.; Kobayashi, K.
10.1101/2023.10.19.563198 — animal behavior and cognition — Posted on 2025-02-18
1985 Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans
Picchetta, L.; Ottolini, C. S.; Tao, X.; Zhan, Y.; Jobanputra, V.; Marin Vallejo, C.; Mulas, F.; Paraboschi, E. M.; Escriba Perez, M. J.; Molinaro, T.; Whitehead, C.; Gill, P.; Mounts, E.; Babariya, D.; Rienzi, L. F.; Ubaldi, F. M.; Garcia Velasco, J. A.; Pellicer, A.; Carmi, S.; Hoffmann, E. R.; Capalbo, A.
10.1101/2025.02.15.637872 — genetics — Posted on 2025-02-18
1987 Aedes albopictus is rapidly invading its climatic niche in France: wider implications for biting nuisance and arbovirus control in Western Europe
Radici, A.; Hammami, P.; Cannet, A.; L'Ambert, G.; Lacour, G.; Fournet, F.; Garros, C.; Guis, H.; Fontenille, D.; Caminade, C.
10.1101/2025.02.14.638223 — ecology — Posted on 2025-02-18
1988 An increase in reactive oxygen species underlies neonatal cerebellum repair
Pakula, A.; El Nagar, S.; Bayin, S.; Christensen, J. B.; Stephen, D.; Reid, A.; Koche, R. P.; Joyner, A. L.
10.1101/2024.10.14.618368 — developmental biology — Posted on 2025-02-18
1989 Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation
Do, C.; Jiang, G.; Cova, G.; Katsifis, C. C.; Narducci, D. N.; Sakellaropoulos, T.; Vidal, R.; Lhoumaud, P.; Tsirigos, A.; Fara Regis, F.; Kakabadze, N.; Nora, E. P.; Noyes, M.; Hansen, A. S.; Skok, J. A.
10.1101/2024.01.11.575070 — molecular biology — Posted on 2025-02-18
1990 Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria
Kapoor, Y.; Khurana, H.; Dutta, D.; Chakraborty, A.; Priya, A.; Singh, A.; Kamat, S.; Dhar, N.; Pucadyil, T.; Nandicoori, V.
10.1101/2024.10.22.619650 — microbiology — Posted on 2025-02-18
1991 The Late-Stage Steps of Burkholderia cenocepacia Protein O-Linked Glycan Biosynthesis Are Conditionally Essential.
Jebeli, L.; McDaniels, T. A.; Ho, D. T. T.; Tahir, H.; Kai-Ming, N. L.; Mcgaw, M.; Karlic, K. I.; Lewis, J. M.; Scott, N. E.
10.1101/2024.11.21.624715 — microbiology — Posted on 2025-02-18
1993 Rhizosphere-colonizing bacteria persist in the protist microbiome
Taerum, S. J.; Patel, R. R.; Alamo, J.; Gage, D. J.; Steven, B.; Triplett, L. R.
10.1101/2025.01.16.633413 — microbiology — Posted on 2025-02-18
1998 Rhizoctonia theobromae associated with a severe witches' broom outbreak in cassava of the Brazilian rainforest and evidence of its Southeast Asian origin
Alves Santos de Oliveira, S.; Sheat, S.; Margaria, P.; Lopes Lima, A.; de Araujo dos Santos, J.; Souza Rocha, H.; Fleck da Silveira, H.; Ramos de Jesus, C.; Winter, S.
10.1101/2025.02.14.638269 — pathology — Posted on 2025-02-18
2001 MARTi: a real-time analysis and visualisation tool for nanopore metagenomics
Peel, N.; Martin, S.; Heavens, D.; Yu, D.; Clark, M. D.; Leggett, R. M.
10.1101/2025.02.14.638261 — bioinformatics — Posted on 2025-02-18
2003 Quantifying state-dependent control properties of brain dynamics from perturbation responses
Shikauchi, Y.; Takemi, M.; Tomasevic, L.; Kitazono, J.; Siebner, H. R.; Oizumi, M.
10.1101/2025.02.18.638784 — neuroscience — Posted on 2025-02-18
2004 Developmental gene expression patterns driving species-specific cortical features
Javed, A.; Gomez, L.; Pravata, V.; LoGiudice, Q.; Sarhadi, M.; Cappello, S.; Klingler, E.; Jabaudon, D.
10.1101/2025.02.18.638637 — neuroscience — Posted on 2025-02-18
2005 Behavioural separation of face memory and face perception
Kadlec, J.; Walsh, C. R.; Wilf, M.; Rissman, J.; Ramot, M.
10.1101/2025.02.17.638018 — neuroscience — Posted on 2025-02-18
2007 Neural and Behavioral Adaptation to Listening with a Unilateral Cochlear Implant (CI)
Woestmann, M.; Meineke, H. M.; Schoenweiler, R.; Hollfelder, D.; Bruchhage, K.-L.; Leichtle, A.; Obleser, J.
10.1101/2025.02.17.638598 — neuroscience — Posted on 2025-02-18
2008 Reduced Fast Periodic Visual Stimulation Oddball Responses to Threatening Faces Associated with Anxiety
Vandenheever, D.; Davidson, H.; Kemp, J.; Murphy, Z.; Kujawa, A.; Shi, C.; Nadorff, M. R.; Bates-Brantley, K.; Sidwell, M.
10.1101/2025.02.15.638321 — neuroscience — Posted on 2025-02-18
2009 Morphological and functional alteration of light perception circuits in AD patients
Sanda, N.; Milea, D.; Kovari, E.; Tong, Y.; Bruegger, T.; Hannibal, J.; Egervari, K. L.; Lobrinus, J. A.; Carrera, E.; Thumann, G.; Kleinlogel, S.; Adamantidis, A.; Mure, L. S.
10.1101/2025.02.18.638646 — neuroscience — Posted on 2025-02-18
2010 Spatial distribution of the proteome in human body and cancers
Yue, L.; Jiang, W.; Li, S.; Luo, M.; Fan, N.; Zhan, X.; Chen, K.; Lu, T.; Guo, F.; Li, D.; Ge, W.; Nie, Z.; Lyu, M.; A, J.; Wang, Y.; Chen, Y.; Fu, Z.; Xiang, N.; Li, L.; Yu, F.; Teo, G. C.; Nesvizhskii, A.; Wang, M.; Snyder, M.; Collins, B. C.; Aebersold, R.; Xu, F.; Liu, T.; Li, Y.; Guo, T.
10.1101/2025.02.14.638212 — systems biology — Posted on 2025-02-18
2011 A Mitochondrially Derived Plastidial Transporter Regulates Photosynthesis in the Diatom Phaeodactylum tricornutum
GIUSTINI, C.; DAL BO, D.; STORTI, M.; Van VLIERBERGHE, M.; BAURAIN, D.; CARDOL, P.; ZHANG, Y.; FERNIE, A. R.; FITZPATRICK, D.; ARO, E.-M.; ALLORENT, G.; ALBANESE, P.; TOLLETER, D.; CURIEN, G.; FINAZZI, G.
10.1101/2025.02.14.638225 — plant biology — Posted on 2025-02-18
2012 Making plant tissue accessible for cryo-electron tomography
Poege, M.; Dickmanns, M.; Xu, P.; Li, M.; Schioetz, O. H.; Kaiser, C.; Ma, J.; Bieber, A.; Capitanio, C.; Brenner, J.; Riggi, M.; Klumpe, S.; Miras, M.; Kazemein Jasemi, N.; Schulze, W.; Simon, R.; Frommer, W.; Plitzko, J.; Baumeister, W.
10.1101/2025.02.14.638237 — plant biology — Posted on 2025-02-18
2015 Benchmarking long-read genome assemblers for three sequencing protocols and three agricultural species
Birbes, C.; Dreau, A.; Milan, D.; Iampietro, C.; Gaspin, C.; Donnadieu, C.; Zytnicki, M.; Klopp, C.
10.1101/2025.02.14.638238 — bioinformatics — Posted on 2025-02-18
2016 DDS-E-Sim: A Transformer-Based Generative Framework for Simulating Error-Prone Sequences in DNA Data Storage
Naznin, M. F. S.; Mondol, S. S.; Faruq, A. I.; Sultan Rumi, A. M.; Saha, D.; Islam, A. B. M. A. A.
10.1101/2025.02.14.637785 — bioinformatics — Posted on 2025-02-18
2017 Characterizing meniscal calcifications with photon counting-based dual-energy computed tomography
Nevanranta, E. A.; Karjalainen, V.-P.; Brix, M.; Hellberg, I.; Shakya, B. R.; Elkhouly, K.; Turkiewicz, A.; Onnerfjord, P.; Ylisiurua, S.; Sjogren, A.; Hughes, V.; Tjornstrand, J.; Saarakkala, S.; Englund, M.; Finnila, M. A. J.
10.1101/2025.02.14.638040 — bioengineering — Posted on 2025-02-18
2019 Data-driven Analysis of Fine-Scale Badger Movement in the UK
Furber, J. R.; Delahay, R.; Cox, R.; Woodroffe, R.; O'Hagan, M.; Klus, S.; Lo Iacono, G.; Chambers, M.; Lloyd, D. J. B.
10.1101/2025.02.14.638245 — ecology — Posted on 2025-02-18
2021 Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline
Segen, V.; Kabir, M. R.; Streck, A.; Slavik, J.; Glanz, W.; Butryn, M.; Newman, E. L.; Tiganj, Z.; Wolbers, T.
10.1101/2025.02.17.638583 — neuroscience — Posted on 2025-02-18
2022 Long-term innovative potential of genetic research and its suppression
Chae, J.; Kim, W.; Jung, W.; Jeong, D.; Lim, R.; Chamlagain, M.; Jung, G.; Jang, J.; Lee, J. W.; Kang, N. K.; Baek, K.; Shin, J.; Lee, Y.-G.; Koh, H. G.; Kim, C.; Yook, S.; Cheung, A. K. L.; Jin, Y.-S.; Youn, H.; Kim, P.-J.; Ghim, C.-M.
10.1101/2025.02.17.638429 — scientific communication and education — Posted on 2025-02-18
2024 Microarray, validation and gene-enrichment approach for assessing differentially expressed circulating miRNAs in obese and lean heart failure patients
Soares, D. d. S.; Lopes, A. d. S.; Recamonde-Mendoza, M.; Bueno, R. H.; Calloni, R.; Clausell, N. d. S.; Tobar Leitao, S. A.; Biolo, A. d. S.
10.1101/2025.02.15.638475 — genomics — Posted on 2025-02-18
2027 No Disconnection Syndrome after Near-Complete Callosotomy
Bekir, S.; Hopf, J. L.; Paul, T.; Wiemer, V. M.; Santander, T.; Skinner, H. E.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.
10.1101/2025.02.16.638524 — neuroscience — Posted on 2025-02-18
2028 Spatio-temporal diversity and genetic architecture of pyrantel resistance in Cylicocyclus nassatus, the most abundant horse parasite
Salle, G.; Courtot, E.; Cabau, C.; Parrinello, H.; Serreau, D.; Reigner, F.; Gesbert, A.; Jacquinot, L.; Lenhof, O.; Aime, A.; Picandet, V.; Kuzmina, T.; Holovachov, O.; Bellaw, J.; Nielsen, M. K.; von Samson-Himmelstjerna, G.; Valiere, S.; Gislard, M.; Lluch, J.; Kuchly, C.; Klopp, C.
10.1101/2023.07.19.549683 — genomics — Posted on 2025-02-18
2029 NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology
Niewold, P.; IJsselsteijn, M. E.; Dijkman, K.; de Miranda, N.; Ottenhoff, T. H. M.; Verreck, F. A. W.; Joosten, S. A.
10.1101/2025.02.14.638234 — immunology — Posted on 2025-02-18
2032 TET3 protects the Dlk1-Dio3 Imprinted Locus from DNA hypomethylation during adult NSC Reprogramming
Ferron, S. R.; Lazaro-Carot, L.; Jimenez-Villalba, E.; Planells, J.; Lozano-Urena, A.; Diaz-Moncho, J.; Montalban-Loro, R.; Lleches-Padilla, A.; Kirstein, M.; Ito, M.; Radford, E. J.
10.1101/2025.02.13.638077 — cell biology — Posted on 2025-02-18
2033 SUMO2 Promotes Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Facilitating U7 snRNP Assembly
He, S.; Lyu, P.; Skinner, M. W.; Desotell, A.; Foley, B.; McCaig, C. M.; Wang, W.; Qian, J.; Tong, L.; Marzluff, W. F.; Matunis, M. J.
10.1101/2025.02.15.638447 — molecular biology — Posted on 2025-02-18
2034 Astrocytic contribution to sensory hypersensitivity in a mouse model of fragile X syndrome
Bergdolt, L.; Anding, A.; Alshaqi, O.; Arbabi, Z.; Douchey, M.; Eldridge, E.; Hoffman, K.; Reid, A.; Sapkota, K.; Padmashri, R.; Monaghan, D.; Taraschenko, O.; Dunaevsky, A.
10.1101/2025.02.14.638346 — neuroscience — Posted on 2025-02-18
2035 Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate
Soattin, L.; Topal, L.; Tikhomirov, R.; Lagomarsino-Oneto, D.; Al-Othman, S.; Saluja, S.; Hornyik, T.; Husti, Z.; Pinter, J.; Mohammed, A. S. A.; Smith, M. N.; Francis, A.; McKie, M.; Torre, E.; Polyak, A.; Farkas, A. S.; Bentzen, B. H.; Keavney, B. D.; Nagy, N.; Jost, N.; Casadei, B.; Mangoni, M. E.; Boyett, M. R.; Varro, A.; Morris, G. M.; Baczko, I.; D'Souza, A.
10.1101/2025.02.12.638004 — physiology — Posted on 2025-02-18
2036 Patient-Specific Pharmacogenomics unveils xCT Regulation Pathways in Colon Cancer
Strecker, M.; Zohar, K.; Böttcher, M.; Wartmann, T.; Freudenstein, H.; Doelling, M.; Andric, M.; Shi, W.; Kakhlon, O.; Hippe, K.; Jahnke, B.; Mougiakakos, D.; Baenke, F.; Stange, D. E.; Croner, R. S.; Linial, M.; Kahlert, U. D.
10.1101/2025.02.11.637634 — cancer biology — Posted on 2025-02-18
2037 Targeting Non-Catalytic Sites of SRC Sensitizes the Efficacy of SRC Kinase Inhibitors in Solid Tumors
Yu, J.; Wang, X.; Liu, P.; Wang, Z.; Liu, J.; Gan, T.; Xu, N.; Zhou, J.; Yu, J.; Yuan, H.; Ban, X.; Liu, Y.; Zhang, X.; Li, P.; Cui, B.
10.1101/2025.02.15.638389 — cancer biology — Posted on 2025-02-18
2038 3D dynamic multiscale force and shape analysis of in-vivo elastic stress sensors
Jurado Jimenez, A.; Isensee, J.; Hofemeier, A.; Krueger, L. J.; Wittkowski, R.; Golestanian, R.; Bittihn, P.; Betz, T.
10.1101/2025.01.22.633835 — biophysics — Posted on 2025-02-18
2039 Key residue Unlocks Dual PIP2-Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels
Nguyen, H.; Mount, J.; Hutchinson, K.; Zhao, Y.; Zhao, Y.; Glaaser, I.; Yuan, P.; Schlessinger, A.; Slesinger, P.
10.1101/2025.02.14.637896 — biophysics — Posted on 2025-02-18
2040 Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels
Taujale, R.; Park, S. J.; Gravel, N.; Soleymani, S.; Carter, R.; Boyd, K.; Keuning, S.; Ruan, Z.; Lü, W.; Kannan, N.
10.1101/2025.02.10.637530 — bioinformatics — Posted on 2025-02-18
2042 Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy
Li, H.; Xie, Z.; Tian, Y.; Lin, B.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Chen, S.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-02-18
2043 Genome Mining of Streptomyces sp. PB17 from Cuatro Cienegas Basin Reveals Biosynthetic Potential for Novel Neurotherapeutics.
Martinez-Olivas, M. A.; Melchor-Rangel, S. A.; Mendoza-Cibrian, M. A.; Benavides-Garcia, P.; De la Torre-Zavala, S.
10.1101/2025.02.12.637946 — genomics — Posted on 2025-02-18
2044 Changes in neural progenitor lineage constituent during astrocytic differentiation of human iPSCs
Li, Z.; Cardo, L. F.; Rokicki, M.; Monzon-Sandoval, J.; Volpato, V.; Wessely, F.; Webber, C.; Li, M.
10.1101/2024.01.22.575551 — developmental biology — Posted on 2025-02-18
2045 Co-translational determination of quaternary structures in chaperone factories
Philippe, M.; Salloum, S.; Slimani, F.; Chasse, H.; Robert, M.-C.; Urbach, S.; Imbert, J.; Seveno, M.; George, S.; Boulon, S.; Verheggen, C.; Bertrand, E.
10.1101/2025.02.12.637890 — cell biology — Posted on 2025-02-18
2049 Flower/1 FLWR-1 regulates neuronal activity via the plasma membrane Ca2+-ATPase to promote recycling of synaptic vesicles
Seidenthal, M.; Redzovic, J.; Liewald, J. F.; Rentsch, D.; Shapiguzov, S.; Schuh, N.; Rosenkranz, N.; Eimer, S.; Gottschalk, A.
10.1101/2024.10.07.617020 — neuroscience — Posted on 2025-02-18
2050 A Novel Method for Culturing Telencephalic Neurons in Axolotls
Bostan, S.; Serdengecti, S.; Bayat, F. K.; Bay, S.; Sezer, A. S.; Aysit, N.; Ozturk, G.
10.1101/2025.02.14.638296 — neuroscience — Posted on 2025-02-18
2052 Heterotypic competition between cancer cells and hepatocytes generates heterogeneous context-dependent phenotypes
Spinazzola, A.; Carvalho, T.; Pinto, M. A. F.; Marques-Reis, M.; Gutierrez-Garcia, A.; Accardi, D.; Moreno, E.
10.1101/2024.05.15.593526 — cancer biology — Posted on 2025-02-18
2054 Tangled up in fibers: How a lytic polysaccharide monooxygenase binds its chitin substrate
Sorensen, H. V.; Montserrat-Canals, M.; Coder, A.; Prevost, S.; Vaaje-Kolstad, G.; Bjerregaard-Andersen, K.; Lund, R.; Krengel, U.
10.1101/2023.09.21.558757 — biochemistry — Posted on 2025-02-18
2056 The fire ant social chromosome exerts a major influence on genome regulation
Jones, B. M.; Waugh, A. H.; Catto, M. A.; Kay, S.; Glastad, K. M.; Goodisman, M. A.; Kocher, S. D.; Hunt, B. G.
10.1101/2025.02.17.638763 — genomics — Posted on 2025-02-18
2060 Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity
Chang, J.; Campbell-Hanson, K. R.; Vanneste, M.; Bartschat, N. I.; Nagel, R.; Arnadottir, A. K.; Nhung Vu, H.; Montgomery, C.; Yevdash, J.; Jiarui, J.; Bhinu, A.; Helverson, A.; Henry, M.; Steingrimsson, E.; Weigel, R. J.; Cornell, R.; Kenny, C.
10.1101/2024.07.11.603140 — cancer biology — Posted on 2025-02-18
2062 VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300
Guo, S.; Hu, X.; Cotton, J. L.; Ma, L.; Li, Q.; Cui, J.; Wang, Y.; Thakare, R. P.; Tao, Z.; Ip, T.; Wu, X.; Wang, J.; Mao, J.
10.1101/2024.05.01.592016 — cancer biology — Posted on 2025-02-18
2063 SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra
Bhattacharya, N.; Rockstroh, A.; Deshpande, S. S.; Thomas, S. K.; Yadav, A.; Goswami, C.; Chawla, S.; Solomon, P.; Fourgeux, C.; Ahuja, G.; Hollier, B.; Kumar, H.; Roquilly, A.; Poschmann, J.; Lehman, M.; Nelson, C. C.; Sengupta, D.
10.1101/2022.12.28.522060 — bioinformatics — Posted on 2025-02-18
2065 Structure and function of the EDEM:PDI ERAD checkpoint complex
Hitchman, C. J.; Lia, A.; Chiritoiu, G. N.; Munteanu, C. V. A.; Ortigosa, J. R.; Ghenea, S.; Savva, C.; De Benedictis, M.; Tax, G.; Bayo, Y.; Crescioli, I.; Alonzi, D. L.; Quigley, A.; Modenutti, C. P.; Petrescu, S. M.; Santino, A.; Gooptu, B.; Roversi, P.
10.1101/2025.01.29.635535 — biochemistry — Posted on 2025-02-18
2066 Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit
Sanders, E. N.; Sun, H.-T.; Tabatabaee, S.; Lang, C. F.; van Dijk, S. G.; Su, Y.-H.; Labott, A.; Idris, J.; He, L.; Marchetti, M.; Xie, S.; O'Brien, L. E.
10.1101/2024.12.29.630675 — developmental biology — Posted on 2025-02-18
2068 Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease
Jacquemyn, J.; Mariott, B.; Chang, J.; Lee, N. Y. J.; Atonal, L. F. R.; Green, C.; Wong, J.; Chik, K.; Acevedo-Morantes, C.; Chen, C. X.- Q.; Nicouleau, M.; You, Z.; Deneault, E.; Abdian, N.; Durcan, T. M.; Jackson, J.; Ioannou, M. S.
10.1101/2025.02.14.638390 — cell biology — Posted on 2025-02-18
2069 A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins
Ryan, M. M.; Portelance, R.; Newman, G. F.; Martinez, G.; Shekharan, S.; Wu, A.; Angel, S.; Schaberg, K. E.; Gilmore, P.; Sprung, R.; Townsend, R.; Naegle, K. M.
10.1101/2024.12.22.629992 — molecular biology — Posted on 2025-02-18
2070 Microsporidia infection alters C. elegans lipid levels
El Jarkass, H. T.; Jeon, J.; Burton, N. O.; Reinke, A. W.
10.1101/2025.02.16.638530 — microbiology — Posted on 2025-02-18
2072 Arousal as a universal embedding for spatiotemporal brain dynamics
Raut, R. V.; Rosenthal, Z. P.; Wang, X.; Miao, H.; Zhang, Z.; Lee, J.-M.; Raichle, M. E.; Bauer, A. Q.; Brunton, S. L.; Brunton, B. W.; Kutz, J. N.
10.1101/2023.11.06.565918 — neuroscience — Posted on 2025-02-18
2073 Patterns of Ongoing Thought in the Real World and Their Link to Mental Health and Well-Being
Mulholland, B.; Chitiz, L.; Wallace, R.; Mckeown, B.; Milham, M.; Klein, A.; Leech, R.; Jefferies, E.; Poerio, G.; Wammes, J.; Stewart, J.; Hardikar, S.; Smallwood, J.
10.1101/2024.07.22.604681 — neuroscience — Posted on 2025-02-18
2076 Single-cell multiomics of neuronal activation reveals context-dependent genetic control of brain disorders
Liang, L.; Zhang, S.; Wang, Z.; Zhang, H.; Li, C.; Duhe, A. C.; Sun, X.; Zhong, X.; Kozlova, A.; Jamison, B.; Wood, W. G.; Pang, Z. P.; Sanders, A. R.; He, X.; Duan, J.
10.1101/2025.02.17.638682 — neuroscience — Posted on 2025-02-18
2079 Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans
Zhou, Y.; Su, Y.; Yang, Q.; Li, J.; Hong, Y.; Gao, T.; Zhong, Y.; Ma, X.; Jin, M.; Liu, X.; Yuan, N.; Kennedy, B. C.; Wang, L.; Yan, L.; Viaene, A. N.; Helbig, I.; Kessler, S. K.; Kleinman, J. E.; Hyde, T. M.; Nauen, D. W.; Liu, C.; Liu, Z.; Shen, Z.; Li, C.; Xu, S.; He, J.; Weinberger, D. R.; Ming, G.-l.; Song, H.
10.1101/2025.02.16.638557 — neuroscience — Posted on 2025-02-17
2087 Predicting animal movement with deepSSF: a deep learning step selection framework
Forrest, S. W.; Pagendam, D.; Hassan, C.; Drovandi, C.; Potts, J. R.; Bode, M.; Hoskins, A. J.
10.1101/2025.02.13.638055 — ecology — Posted on 2025-02-17
2089 Animal tracking with particle algorithms for conservation
Lavender, E.; Scheidegger, A.; Albert, C.; Biber, S. W.; Brodersen, J.; Aleynik, D.; Cole, G.; Dodd, J.; Wright, P. J.; Illian, J.; James, M.; Smout, S.; Thorburn, J.; Moor, H.
10.1101/2025.02.13.638042 — ecology — Posted on 2025-02-17
2093 A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor
Raynaud, P.; Gourdon, J.; Jugnarain, V.; Berthet, L.; Jean-Alphonse, F.; Vaugrente, O.; Gauthier, C.; Vallet, A.; Anujan, P.; Naquin, D.; Boulo, T.; Gauthier, C.; Klett, D.; Yves, C.; Hanyaloglu, A.; Reiter, E.; Bruneau, G.; Crepieux, P.
10.1101/2025.02.13.638052 — pharmacology and toxicology — Posted on 2025-02-17
2094 A mixture of endocrine disrupting chemicals linked to lower birth weight induces adipogenesis and transcriptional changes related to birth weight alterations and diabetes
Lizunkova, P.; Caporale, N.; Engdahl, E.; Cheroni, C.; Germain, P.-L.; Borbelye, G.; Lindh, C.; Gennings, C.; Bornehag, C.-G.; Testa, G.; Ruegg, J.
10.1101/2025.02.13.638050 — pharmacology and toxicology — Posted on 2025-02-17
2095 The interplay of climate change, urbanization, and species traits shapes European butterfly population trends
Colom, P.; Tejeda, A.; Bonelli, S.; Fontaine, B.; Kuussaari, M.; Maes, D.; Mestdagh, X.; Munguira, M. L.; Musche, M.; Pettersson, L. B.; Roy, D.; Rudisser, J.; Sasic, M.; Schmucki, R.; Stefanescu, C.; Titeux, N.; Settele, J.; van Swaay, C.; Gordillo, J.; Melero, Y.
10.1101/2025.02.13.638066 — ecology — Posted on 2025-02-17
2097 High Enzyme Promiscuity in Lignin Degradation Mechanisms in Rhodopseudomonas palustris CGA009
Kathol, M.; Chowdhury, N. B.; Immethun, C.; Alsiyabi, A. W.; Morris, D.; Naldrett, M. J.; Saha, R.
10.1101/2025.02.15.638337 — bioengineering — Posted on 2025-02-17
2101 Reversable Acute Sedation Response of Phosphorothioate Antisense Oligonucleotides Following Local Delivery to the Central Nervous System
O'Rourke, J. G.; Bachmann, G.; Mazur, C.; Zhou, K.; Platoshyn, O.; Hernandez, M. B.; Klein, S.; Nguyen, J.; Burel, S.; Hoffmaster, C.; Zanardi, T.; Jafar-nejad, P.; Marsala, M.; Henry, S. P.; Swayze, E. E.; Powers, B.; Kordasiewicz, H. B.
10.1101/2025.02.13.638136 — neuroscience — Posted on 2025-02-17
2102 The 5-HT1F Receptor Agonist Lasmiditan improves Cognition and Ameliorates Associated Cortico-Hippocampal Pathology in Aging Parkinsonian Mice
Ishii, A.; Meredith, J. R.; Corenblum, M. J.; Bernard, K.; Wene, P.; Menakuru, N.; Santiago, P. V.; Schnellmann, R. G.; Madhavan, L.
10.1101/2025.02.13.638147 — neuroscience — Posted on 2025-02-17
2106 Host-microbe mutualism drives urea carbon salvage and acetogenesis during hibernation
Regan, M.; Chiang, E.; Grahn, M.; Tonelli, M.; Assadi-Porter, F. M.; Suen, G.; Carey, H. V.
10.1101/2025.02.13.638127 — physiology — Posted on 2025-02-17
2108 Regioselectively Acetylated Silybin Derivatives and their Cytotoxic Activity in Liver Cancer Cells
Tran, C. V.; Tran, T. T. P.; Nguyen, A. T.; Loc, T. V.; Garrett, M. D.; Do, T. T.; Serpell, C.; Tran, S. V.
10.1101/2025.02.13.638106 — pharmacology and toxicology — Posted on 2025-02-17
2110 Tissue reassembly with generative AI
Yu, T.; Ekbote, C.; Morozov, N.; Fan, J.; Frossard, P.; d'Ascoli, S.; Brbic, M.
10.1101/2025.02.13.638045 — bioinformatics — Posted on 2025-02-17
2116 Massive Chromosome Fission and Speciation in Asian River Chub: Integrating Kinetochore Reproduction Theory with Transposable Element Dynamics
Tai, J.-H.; Wang, T.-Y.; Ma, G.-C.; Wu, Y.-W.; Yu, T.-H.; Wang, C.-F.; Liao, T.-Y.; Huang, S.-P.; Wang, F.-Y.; Terai, Y.; Wu, T.-H.; Hsu, C.-H.; Yu, H.-T.; Shao, K.-T.; Chaw, S.-M.; Wang, H.-Y.
10.1101/2025.02.13.638213 — genomics — Posted on 2025-02-17
2118 An RNA Splicing System that Excises Transposons from Animal mRNAs
Zhao, L.-W.; Nardone, C.; Paulo, J. A.; Elledge, S.; Kennedy, S.
10.1101/2025.02.14.638102 — genetics — Posted on 2025-02-17
2119 Wolbachia feminizes a spider host with assistance from co-infecting symbionts
Mackevicius-Dubickaja, V.; Gottlieb, Y.; White, J. A.; Doremus, M. R.
10.1101/2025.02.13.638118 — ecology — Posted on 2025-02-17
2120 Reducing batch effects in single cell chromatin accessibility measurements by pooled transposition with MULTI-ATAC
Conrad, D. N.; Phong, K. T.; Korotkevich, E.; McGinnis, C. S.; Zhu, Q.; Chow, E. D.; Gartner, Z. J.
10.1101/2025.02.14.638353 — molecular biology — Posted on 2025-02-17
2122 Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection
Vazquez Marrero, V. R.; Doerner, J.; Wodzanowski, K. A.; Zhang, J.; Lu, A.; Boyer, F. D.; Vargas, I.; Hossain, S.; Kammann, K. B.; Dresler, M. V.; Shin, S.
10.1101/2025.02.13.638189 — immunology — Posted on 2025-02-17
2123 Tuning of Task-Relevant Stiffness in Multiple Directions
Zhang, C.; Tessari, F.; Hermus, J.; Akolkar, H.; Hogan, N.; Schwartz, A.
10.1101/2025.02.13.637671 — neuroscience — Posted on 2025-02-17
2124 Synaptotoxic forms of amyloid-b and a-synuclein act through a common pathway.
Ribe, E.; Ghosh, A.; Paslawski, W.; Savory, K. A.; Ballard, C.; Morin, P.; Cash, D.; Hirth, F.; Williams, G.; Svenningsson, P.; Aarsland, D.; Siow, R. C.; Killick, R.
10.1101/2025.02.13.638131 — neuroscience — Posted on 2025-02-17
2126 Significant variations in tolerance to clothianidin and pirimiphos-methyl in Anopheles gambiae and Anopheles funestus populations during a dramatic malaria resurgence despite sustained indoor residual spraying in Uganda
Oruni, A.; Arinaitwe, E.; Adiga, J.; Otto, G.; Kyagamba, P.; Okoth, J.; Ayo, D.; Asiimwe, J. R.; Zedi, M.; Rek, J.; Walker, K. J.; Braithwaite, A.; Kayondo, J.; Conrad, M. D.; Bousema, T.; Paine, M. J. I.; Ismail, H. M.; Krezanoski, P.; Wondji, C. S.; Kamya, M. R.; Dorsey, G.; Donnelly, M. J.
10.1101/2025.02.13.638152 — zoology — Posted on 2025-02-17
2131 Kingdom-Wide CRISPR Guide Design with ALLEGRO
Mohseni, A.; Ghorbani Nia, R.; Tafrishi, A.; Liu, X.-Z.; Stajich, J. E.; Wheeldon, I.; Lonardi, S.
10.1101/2025.02.13.638206 — bioinformatics — Posted on 2025-02-17
2136 Off-target detection of CRISPR-Cas9 nuclease in vitro with CROFT-Seq
Toliusis, P.; Grybauskas, A.; Sinkunas, T.; Karvelis, T.; Sasnauskas, G.; Zaremba, M.
10.1101/2025.02.17.638614 — biochemistry — Posted on 2025-02-17
2138 Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression
Melton, R.; Jimenez, S.; Elison, W.; Tucciarone, L.; Howell, A.; Wang, G.; Berti, D.; Beebe, E.; Miller, M.; Zeng, C.; Vanderstel, K.; Korgaonkar, K.; Elgamal, R.; Mummey, H.; Chiou, J.; Griffin, E.; Kusmartseva, I.; Atkinson, M. A.; Preissl, S.; Theis, F.; Sander, M.; Gaulton, K. J.
10.1101/2025.02.13.637721 — genomics — Posted on 2025-02-17
2139 Contribution of floral transmission to the assembly and health impact of bacterial communities in watermelon seeds
Bergmann, G. E.; Lui, K.; Lopez, C.; Velasco, A.; Marais, C.; Barret, M.; Simonin, M.; Vannette, R. L.; Leveau, J. H. J.
10.1101/2025.02.12.637993 — ecology — Posted on 2025-02-17
2142 Myocardial cGMP-PKG1alpha dysregulation contributes to VT pathogenesis in type II diabetes and metabolic syndrome.
Cao, X.; Zhang, Y.; Tripp, A. E.; Steinhauer, R.; Liu, P.; Aronovitz, M.; Martin, G. L.; Wang, B.; Alissa, A.; AlJuaid, M.; Ho, J.; Phan, T.; Madias, C.; Blanton, R.; Galper, J. B.
10.1101/2025.02.12.638003 — molecular biology — Posted on 2025-02-17
2146 Calcite Precipitation by a Nitrogen-Fixing Cyanobacterium
Brininger, C. M.; Tay, J. W.; Johnson, E. B.; Espelie, E.; Cameron, J. C.
10.1101/2025.02.17.638518 — microbiology — Posted on 2025-02-17
2147 Deep-learning-based interpolation of longitudinal microbiome data powers biologically informative discovery
Qu, Y.; Lyu, R.; Wang, D.; Dai, Y.; Turcan, A.; Yu, S.; Xie, J.; Roach, J.; Butler, C.; Yap, P.-T.; Zhu, H.; Dashper, S.; Ribeiro, A. A.; Li, D.; Divaris, K.; Wu, D.
10.1101/2025.02.17.638709 — microbiology — Posted on 2025-02-17
2149 Diverse Viral Pathogens in Australian Canines: Limited Geographic Structure and the First Detection of an RNA Virus in Dingoes
Mifsud, J. C.; Harvey, E.; Van Brussel, K.; Olsson, A.; Pitcher, B. J.; Hall, J.; Fenton, H.; Alting, B. F.; Sadiq, S.; Holmes, E. C.
10.1101/2025.02.16.638538 — microbiology — Posted on 2025-02-17
2150 Biological function and mechanism of flpL gene in regulating pathogenicity of Aeromonas hydrophila
Jiao, H.; Liu, K.; Liao, Z.; Naseer, A.; Ye, H.; Xu, H.; Li, Y.; Yu, Y.; Mei, H.; Wu, R.
10.1101/2025.02.17.638635 — microbiology — Posted on 2025-02-17
2151 Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.
Mestrallet, G.; Brown, M.; Vaninov, N.; Cho, N. W.; Velazquez, L.; Ananthanarayanan, A.; Spitzer, M.; Vabret, N.; Cimen Bozkus, C.; Samstein, R. M.; Bhardwaj, N.
10.1101/2025.02.12.637954 — immunology — Posted on 2025-02-17
2152 DynamoSort: Using machine learning approaches for the automatic classification of seizure dynamotypes
Wooley, J.; Zachery-Savella, A.; Le, M.; Scofield, S.; Jay, K.; Mosse-Robinson, J.; West, P. J.; Wilcox, K. S.; Anderson, D. N.
10.1101/2025.02.12.637999 — neuroscience — Posted on 2025-02-17
2153 Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults
Gamage, N. N.; Altheyab, A.; Guo, Y.; Phillips, B. E.; Opie, G. M.; Semmler, J. G.; Atherton, P.; Piasecki, M.
10.1101/2025.02.13.638001 — physiology — Posted on 2025-02-17
2154 VIRUS-MVP: A framework for comprehensive surveillance of viral mutations and their functional impacts
Anwar, M. Z.; Gill, I. S.; Iseminger, M.; Sehar, A.; Griffiths, E. J.; Dooley, D.; Duan, J.; Vora, K.; Van Domselaar, G.; Brinkman, F. S. L.; Gordon, P. M. K.; Hsiao, W. W. L.
10.1101/2025.02.16.636315 — bioinformatics — Posted on 2025-02-17
2157 Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering
Stewart, M.; Paththamperuma, C.; McCann, C.; Cottingim, K.; Peng, I.; Fennimore, E.; Saeed, M.; Colie, M.; Paulakonis, E.; Almeida, M. F.; Afolayan, A. J.; Brown, N.; Page, R. C.; Schisler, J. C.
10.1101/2025.02.17.637997 — biochemistry — Posted on 2025-02-17
2159 Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
San Felipe, C.; Batra, J.; Muralidharan, M.; Malpotra, S.; Anand, D.; Bauer, R.; Verba, K. A.; Swaney, D. L.; Krogan, N. J.; Grabe, M.; Fraser, J. S.
10.1101/2025.02.16.638509 — biochemistry — Posted on 2025-02-17
2161 Phenethylaminylation: Preliminary In Vitro Evidence for the Covalent Transamidation of Psychedelic Phenethylamines to Glial Proteins using 3,5-Dimethoxy-4-(2-Propynyloxy)-Phenethylamine as a Model Compound
Rangan, R. S.; Petty, R. M.; Acharya, S.; Emmitte, K. A.; do Valle, R. S.; Lam, C.; Essajee, S. I.; Mayhew, W.; Young, O.; Brooks, C. D.; Forster, M. J.; Tovar-Vidales, T.; Clark, A. F.
10.1101/2025.02.13.638188 — molecular biology — Posted on 2025-02-17
2163 Age- and Virus-Specific Signatures of In Vitro Reconstituted Human Airway Epithelia in the Presence and Absence of Respiratory Viral Infections
Bellon, M.; Alvarez, C.; Buendia, G. R.; Sattonnet-Roche, P.; Dbeissi, D.; Sarmiento, Y.; Kaiser, L.; Didierlaurent, A. M.; Eckerle, I.; Essaidi-Laziosi, M.
10.1101/2025.02.16.638411 — microbiology — Posted on 2025-02-17
2168 StarTrace: A Multiplex Organoid Avatar Drug Testing Platform for Personalized Medicine
Khalili, S.; patel, S.; Patel, N.; Moy, V.; Lyons, S.; Gray, E.; Brents, R.; Banister, C. E.; Morrison, S. E.; Buckhaults, P. J.
10.1101/2025.02.12.637574 — molecular biology — Posted on 2025-02-17
2169 Proteomic Landscape of Pattern Triggered Immunity in the Arabidopsis Leaf Apoplast
Chen, H.-C.; Newton, C. J.; Diaz, G.; Zheng, Y.; Kong, F.; Yao, Y.; Yang, L.; Kvitko, B. H.
10.1101/2025.02.06.636724 — plant biology — Posted on 2025-02-17
2170 Single Cell RNA-sequencing of BCG naive and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM mediated immune-suppressive pathway
Juric, I.; Fink, E. E.; Qiu, H.; Desprez, P.-E.; RAVI, A.; Holton, M.; Makarov, V.; Almassi, N.; Min, B.; Getz, G.; Chan, T.; Alban, T.; Ting, A. H.; Lee, B. H.
10.1101/2025.02.13.638074 — cancer biology — Posted on 2025-02-17
2171 Machine Learning-Enhanced Extraction of Protein Signatures of Renal Cell Carcinoma from Proteomics Data
Liu, H.; Ma, Z.; Lih, T. M.; Chen, L.; Hu, Y.; Wang, Y.; Sun, Z.; Huang, Y.; Xu, Y.; Zhang, H.
10.1101/2025.02.17.638651 — cancer biology — Posted on 2025-02-17
2172 The cellular state space of AML unveils novel NPM1 subtypes with distinct clinical outcomes and immune evasion properties
Lilljebjörn, H.; Pena-Martinez, P.; Thorsson, H.; Henningsson, R.; Rissler, M.; Landberg, N.; Puente-Moncada, N.; von Palffy, S.; Rissler, V.; Stanek, P.; Desponds, J.; Zhong, X.; Juliusson, G.; Lazarevic, V.; Lehmann, S.; Fontes, M.; Agerstam, H.; Sanden, C.; Orsmark-Pietras, C.; Fioretos, T.
10.1101/2025.02.12.637826 — cancer biology — Posted on 2025-02-17
2174 Intraline genomic heterogeneity of the triple-negative breast cancer MDA-MB-231 cell line
Varela-Rouco, N.; Estevez-Gomez, N.; Fernandez-Santiago, C.; Tomas, L.; Perez, M.; Garcia-Souto, D.; Pasantes, J. J.; Pineiro, R.; Alves, J. M.; Posada, D.
10.1101/2025.02.13.638020 — genomics — Posted on 2025-02-17
2176 RNA virus ecogenomics along a subarctic permafrost thaw gradient
Pratama, A. A.; Dominguez-Huerta, G.; Wainaina, J. M.; Bolduc, B.; Tian, F.; Ellenbogen, J.; Guo, J.; EMERGE Field Team, ; EMERGE Coordinators, ; Wrighton, K. C.; Zayed, A. A.; Sullivan, M. B.
10.1101/2025.02.13.637936 — microbiology — Posted on 2025-02-17
2177 Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation.
Murray, K.; Cremin, M.; Tay, E. X. Y.; Sanchez, K. R.; Schreiber, S.; Brust-Mascher, I.; Leigh, W.; Ashfaq, J.; Gareau, M. G.; Reardon, C.
10.1101/2025.02.12.637880 — immunology — Posted on 2025-02-17
2179 Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease
Trushin, S.; Nguyen, O.; Stojakovic, A.; Ostroot, M.; Deason, T.; Chang, S.-y.; Zhang, L.; Macura, S.; Nambara., T.; Kanekiyo, T.; Lu, W.; Trushina, E.
10.1101/2025.02.12.637918 — neuroscience — Posted on 2025-02-17
2181 Non-invasive imaging of salicylic and jasmonic acid activities in planta
Balakireva, A. V.; Karataeva, T. A.; Karampelias, M.; Mitiouchkina, T. Y.; Machacek, J.; Shakhova, E. S.; Perfilov, M. M.; Belozerova, O. A.; Palkina, K. A.; Drazna, N.; Vondrakova, Z.; Fleiss, A.; Fakhranurova, L. I.; Markina, N. M.; Morozov, V. V.; Bugaeva, E. N.; Delnova, G. M.; Choob, V. V.; Yampolsky, I. V.; Petrasek, J.; Mishin, A. S.; Sarkisyan, K. S.
10.1101/2025.02.17.636591 — plant biology — Posted on 2025-02-17
2183 Single-sample, multi-omic mass spectrometry for investigating mechanisms of drug toxicity
Mahmud, I.; Chan, W.-K.; Yannell, K.; Simmermaker, C.; Van de Bittner, G.; Wu, L.; Chan, D.; Mohsin, S. B.; Liu, Y.; Sausen, J.; Weinstein, J. N.; Lorenzi, P. L.
10.1101/2025.02.13.638125 — cancer biology — Posted on 2025-02-17
2185 A pathogenic subpopulation of human glioma associated macrophages linked to glioma progression
Yu, K. K. H.; Abou-Mrad, Z.; Torkenczy, K.; Schulze, I.; Gantchev, J.; Baquer, G.; Hopland, K.; Bander, E. D.; Tosi, U.; Brennan, C.; Moss, N. S.; Hamard, P.-J.; Koche, R.; Lareau, C.; Agar, N. Y. R.; Merghoub, T.; Tabar, V.
10.1101/2025.02.12.637857 — cancer biology — Posted on 2025-02-17
2186 Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
Li, S.; Song, K.; Sun, H.; Tao, Y.; Huang, A.; Bhatia, V.; Hanratty, B.; Patel, R. A.; Long, H. W.; Morrissey, C.; Haffner, M. C.; Nelson, P. S.; Graeber, T. G.; Lee, J. K.
10.1101/2025.02.12.637904 — cancer biology — Posted on 2025-02-17
2187 comBO: A combined human bone and lympho-myeloid bone marrow organoid for pre-clinical modelling of haematopoietic disorders
Shen, Y.; Benlabiod, C.; Rodriguez-Romera, A.; Watson, E.; Reyat, J. S.; Gurashi, K.; Adnan-Awad, S.; Hargreaves, R.; Kemble, S.; Smith, C. G.; Croft, A. P.; Oppermann, U.; Jooss, N.; Wong, Z. C.; Rayes, J.; Mead, A. J.; Roy, A.; Gooding, S.; Psaila, B.; Khan, A. O.
10.1101/2025.02.16.638505 — cancer biology — Posted on 2025-02-17
2188 Optimal marker genes for c-separated cell types
Borozan, B.; Borozan, L.; Severdija, D.; Matijevic, D.; Canzar, S.
10.1101/2025.02.12.637849 — bioinformatics — Posted on 2025-02-17
2190 ClusterApp to visualize, organize, and navigate metabolomics data
Hansel, V.; Karunarathne, P.; Borelli, T. C.; Quinn, R.; da Silva, R. R.
10.1101/2025.02.12.637912 — bioinformatics — Posted on 2025-02-17
2195 Database Chemistry for Genomics-Based Safety and Quality Evaluation of Biologics
Ogata, N.; Matsuda, T.; Hosaka, A.; Shina, A.; Hashiba, N.; Uchida, K.; Kawabe, Y.; Kamihira, M.; Yamaoka, T.; Kunita, H.; Yamano-Adachi, N.; Omasa, T.
10.1101/2025.02.14.638017 — bioengineering — Posted on 2025-02-17
2199 Structure-based analysis unveils co-origin of LPOR and nitrogenase-like proteins
Sun, X.; Ma, L.; Zeng, F.; Hong, Y.; Dixon, R.; Rao, Z.; Zhao, G.; Zhao, J.; Zhang, C.; Wu, M.; Ma, C.; Yu, X.; Yang, J.; Purton, S.; Ermilova, E.; Scrutton, N.; Silva, P.; Zhao, J.; Cheng, Q.
10.1101/2025.02.17.634645 — evolutionary biology — Posted on 2025-02-17
2200 Diatom biodiversity response to shrinking glaciers in the Peruvian Andes
Kerr, N. R.; Quincey, D.; Fell, S. C.; Kelly, M.; Medina, K.; Loarte, E.; Brown, L. E.
10.1101/2025.02.17.635084 — ecology — Posted on 2025-02-17
2201 Predicting mammal species suitable for Chagas disease spread
Rocha-Ortega, M.; Botto-Mahan, C.; Rojo, G.; Cordoba-Aguilar, A.
10.1101/2025.02.13.638026 — ecology — Posted on 2025-02-17
2204 Overcoming Cisplatin Resistance in TP53-null Colon Cancer Organoids
Khalili, S.; Heine, P.; Khazan, M.; Banister, C. E.; Morrison, S. E.; Buckhaults, P. J.
10.1101/2025.02.12.637569 — molecular biology — Posted on 2025-02-17
2206 IMMUNOGENICITY AND SAFETY OF CHICKEN EMBRYO FIBROBLAST ADAPTED FOWLPOX VACCINE
Okafor, U. S.; Israel, S.; Meseko, C. A.; Adediran, O. A.; Ogunmolawa, O. R.; Darang, A.; Bwala, D. G.
10.1101/2025.02.12.637982 — immunology — Posted on 2025-02-17
2207 Neutrophil Reprogramming Underlie Vasculopathy and Lung Disease in Systemic Sclerosis
Maugeri, N.; Ramirez, G. A.; Capobianco, A.; Monno, A.; Bianchi, M. E.; Rovere Querini, P.; Matucci Cerenic, M.; Manfredi, A. A.
10.1101/2025.02.12.637866 — immunology — Posted on 2025-02-17
2212 A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD
Ebner, L. J. A.; Imsand, C.; Karademir, D.; Peters, F.; Kiessling, E.; Fottner, A.; Matter, C.; Fajardo, D. S.; Merolla, L.; Woegenstein, G. M.; Tsioti, I.; Govers, L. P.; Blaser, F.; Meneau, I.; Boye, S. L.; Boye, S. E.; Grimm, C.; Samardzija, M.
10.1101/2024.11.29.626080 — neuroscience — Posted on 2025-02-17
2213 Altered reactivity to threatening stimuli in Drosophila models of Parkinson's disease, revealed by a trial-based assay
Kajtor, M.; Billes, V. A.; Kiraly, B.; Karkusova, P.; Kovacs, T.; Stabb, H.; Sviatko, K.; Vizi, A.; Ujvari, E.; Balazsfi, D.; Seidenbecher, S. E.; Kvitsiani, D.; Vellai, T.; Hangya, B.
10.1101/2023.08.29.555311 — neuroscience — Posted on 2025-02-17
2216 Adaptive time course of the skeletal muscle proteome during programmed resistance training in rats
Stead, C. A.; Hesketh, S. J.; Thomas, A. C. Q.; Sutherland, H.; Jarvis, J. C.; Burniston, J. G.
10.1101/2025.02.17.633647 — physiology — Posted on 2025-02-17
2219 Ligand Discrimination in Immune Cells: Signal Processing Insights into Immune Dysfunction in ER+ Breast Cancer
Matache, A.; Rodrigues Lima, J.; Kuznetsov, M.; Urbaniak, K.; Branciamore, S.; Rodin, A.; Lee, P. P.; Rockne, R. C.
10.1101/2025.02.15.638458 — cancer biology — Posted on 2025-02-17
2221 CITEgeist: Cellular Indexing of Transcriptomes and Epitopes for Guided Exploration of Intrinsic Spatial Trends
Chang, A. C.-C.; Schlegel, B. T.; Carleton, N.; McAulife, P. F.; Oesterreich, S.; Schwartz, R.; Lee, A. V.
10.1101/2025.02.15.638331 — cancer biology — Posted on 2025-02-17
2222 RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia
Derevyanko, P. K.; Swart, L. E.; Casimiro, L. D. M.; van den Brink, L.; van Oort, A. T.; Ashtiani, M.; Zwaan, C. M.; Krippner-Heidenreich, A.; Bonifer, C.; Schiffelers, R.; Vormoor, H. J.; Kellaway, S. G.; Heidenreich, O.
10.1101/2025.02.13.637937 — cancer biology — Posted on 2025-02-17
2223 AMPK- and cGAS-Mediated Dual Sensing of Glucose and dsDNA Synergizes to Enhance Antitumor Immunity
Xu, P.; Zhou, R.; Pei, J.; Chen, S.; Shen, Q.; Wu, Q.; Liu, S.; Feng, X.-H.; Zou, J.; Liang, T.; Zhang, Y. J.; Lin, S.-C.; Song, P.; Zhang, C.-S.; Zhang, Q.
10.1101/2025.02.15.638470 — cancer biology — Posted on 2025-02-17
2224 The uptake of metallic nanoparticles in breast cancer cell lines is modulated by the HA-CD44 axis.
Hullo, M.; Mathe, C.; Fonknechten, N.; Lallemand, C.; Piton, G.; Noireaux, J.; Chevillard, S.; Campalans, A.; Bourneuf, E.
10.1101/2025.02.12.637873 — cancer biology — Posted on 2025-02-17
2225 Signals from the bone marrow B cell niches shape pre-leukemic fate in murine B cell acute lymphoblastic leukemia
Delahaye, M. C.; Leonard, S.; Pelletier, J.; Destin, J.; Bardin, F.; Ounis, M.; Monvoisin, C.; Prade, N.; Gil, L.; Dauba, A.; Milpied, P.; Khamlichi, A. A.; Delabesse, E.; Marchand, T.; Broccardo, C.; Aurrand-Lions, M.; Gerby, B.; Mancini, S. J.
10.1101/2025.02.14.638228 — cancer biology — Posted on 2025-02-17
2226 RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors
Baars, B.; Orive-Ramos, A.; Kou, Z.; Gaire, B.; Desaunay, M.; Adamopoulos, C.; Aaronson, S. A.; Wang, S.; Poulikakos, P. I.
10.1101/2025.02.14.638317 — cancer biology — Posted on 2025-02-17
2231 Clonal memory of colitis accumulates and promotes tumor growth
Nagaraja, S.; Ojeda-Miron, L.; Zhang, R.; Oreskovic, E.; Hu, Y.; Zeve, D.; Sharma, K.; Hyman, R. R.; Zhang, Q.; Castillo, A.; Breault, D. T.; Yilmaz, O. H.; Buenrostro, J. D.
10.1101/2025.02.13.638099 — cancer biology — Posted on 2025-02-17
2232 Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture
Kohlhas, V.; Jestrabek, H.; Rebollido-Rios, R.; Truong, T. T.; Zoelzer, R.; Schreurs, L. D.; von Lom, A.; vom Stein, A. F.; Hallek, M.; Nguyen, P.-H.
10.1101/2025.02.13.638101 — cancer biology — Posted on 2025-02-17
2235 Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)
Deganutti, G.; Pipito, L.; Rujan, R. M.; Weizmann, T.; Griffin, P.; Ciancetta, A.; Moro, S.; Reynolds, C. A.
10.1101/2022.10.26.513870 — bioinformatics — Posted on 2025-02-17
2236 Generation of antigen-specific paired chain antibody sequences using large language models
Wasdin, P. T.; Johnson, N. V.; Janke, A. K.; Held, S.; Marinov, T. M.; Jordaan, G.; Vandenabeele, L.; Pantouli, F.; Gillespie, R. A.; Vukovich, M. J.; Holt, C. M.; Kim, J.; Hansman, G.; Logue, J.; Chu, H. Y.; Andrews, S. F.; Kanekiyo, M.; Sautto, G. A.; Ross, T. M.; Sheward, D. J.; McLellan, J. S.; Abu-Shmais, A. A.; Georgiev, I. S.
10.1101/2024.12.20.629482 — bioinformatics — Posted on 2025-02-17
2240 Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells
Wu, W.; Lam, A. R.; Suarez, K.; Smith, G. N.; Duquette, S. M.; Yu, J.; Mankus, D.; Bisher, M.; Lytton-Jean, A.; Manalis, S. R.; Miettinen, T. P.
10.1101/2024.07.02.601447 — cell biology — Posted on 2025-02-17
2241 A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
Peres, A.; Upadhyay, A. A.; Klein, V. H.; Saha, S.; Rodriguez, O. L.; Vanwinkle, Z. M.; Karunakaran, K.; Metz, A.; Lauer, W.; Lin, M. C.; Melton, T.; Granholm, L.; Polak, P.; Peterson, S. M.; Peterson, E. J.; Raju, N.; Shields, K.; Schultze, S.; Ton, T.; Ericsen, A.; Lapp, S. A.; Villinger, F. J.; Ohlin, M.; Cottrell, C.; Amara, R. R.; Derdeyn, C. A.; Crotty, S.; Schief, W.; Karlsson Hedestam, G. B.; Smith, M.; Lees, W.; Watson, C. T.; Yaari, G.; Bosinger, S. E.
10.1101/2025.01.07.631319 — immunology — Posted on 2025-02-17
2243 Evaluating Synthetic Diffusion MRI Maps created with Diffusion Denoising Probabilistic Models
Chattopadhyay, T.; Jagad, C.; Kush, R.; Desai, V. D.; Thomopoulos, S. I.; Villalon-Reina, J. E.; Thompson, P. M.
10.1101/2024.11.06.621173 — neuroscience — Posted on 2025-02-17
2244 Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer.
McErlain, T.; Glass, M. J.; McCulla, E. C.; Madden, C. A.; Ziemer, L. E.; Overdahl, K. E.; Jarmusch, A. K.; Kruhlak, M. J.; Chesler, A.; Yang, H. H.; Lee, M. P.; Branco, C. M.; Murgai, M. M.
10.1101/2025.02.15.638347 — cancer biology — Posted on 2025-02-17
2245 A dual mechanism of sensitivity to PLK4 inhibition by RP-1664 in neuroblastoma
Soria-Bretones, I.; Casas-Selves, M.; Goodfellow, E.; Li, L.; Caron, C.; Shiwram, A.; Kim, H.; Henry, D.; Laterreur, N.; Bowlan, J.; Alvarez-Quilon, A.; Vallee, F.; Veloso, A.; Young, J. T. F.; Hyer, M. L.; Morris, S. J.; Marshall, C. G.; Zimmermann, M.
10.1101/2025.02.15.638336 — cancer biology — Posted on 2025-02-17
2246 Targeting Pre-existing Club-Like Cells in Prostate Cancer Potentiates Androgen Deprivation Therapy
Baures, M.; Aleixo, A.-S. V.; Pacreau, E.; Koshy, A.; Diedisheim, M.; Raigel, M.; Hua, Y.; Dariane, C.; Boutillon, F.; Kenner, L.; Marine, J.-C.; Laverny, G.; Metzger, D.; Rambow, F.; Guidotti, J.-E.; Goffin, V.
10.1101/2025.02.13.637653 — cancer biology — Posted on 2025-02-17
2247 Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Eapen, R.; Okoye, C.; Stubbs, C.; Schimpl, M.; Tischer, T.; Fisher, E. J.; Zacharopoulou, M.; Ferrer, F.; Barford, D.; Spring, D.; Lindon, C.; Phillips, C.; Itzhaki, L. S.
10.1101/2024.04.30.590460 — biochemistry — Posted on 2025-02-17
2250 A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Saunders, R. A.; Allen, W. E.; Pan, X.; Sandhu, J.; Lu, J.; Lau, T. K.; Smolyar, K.; Sullivan, Z.; Dulac, C.; Weissman, J. S.; Zhuang, X.
10.1101/2024.11.18.624217 — genomics — Posted on 2025-02-17
2251 Declining juvenile survival of Adelie penguins in Antarctica
Barracho, T.; Bardon, G.; Choquet, R.; Houstin, A.; Winterl, A.; Beaulieu, M.; Blanchard, P.; Cornet, C. C.; Cristofari, R.; Raclot, T.; Richter, S.; Chatelain, N.; Courtecuisse, J.; Brucker, M.; Zitterbart, D. P.; Lecomte, N.; Le Bohec, C.
10.1101/2024.08.23.609289 — ecology — Posted on 2025-02-17
2255 Integrative Epigenomic Landscape of Alzheimer's Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with Tau
Oatman, S. R.; Reddy, J. S.; Atashgaran, A.; Wang, X.; Min, Y.; Quicksall, Z.; Vanelderen, F.; Carrasquillo, M. M.; Liu, C.-C.; Yamazaki, Y.; Nguyen, T. T.; Heckman, M.; Zhao, N.; DeTure, M.; Murray, M. E.; Bu, G.; Kanekiyo, T.; Dickson, D. W.; Allen, M.; Ertekin-Taner, N.
10.1101/2025.02.12.637140 — genomics — Posted on 2025-02-17
2258 L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neurons
Radlicka-Borysewska, A.; Ziemianska, M.; Zieba, M.; Szumiec, Łukasz; Baginska, M.; Chroszcz, M.; Gołda, S.; Hajto, J.; Korostynski, M.; Kreiner, G.; Pera, J.; Piechota, M.; Parkitna, J. M. R.
10.1101/2025.02.13.638140 — neuroscience — Posted on 2025-02-17
2260 Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
Wang, Q.; Li, H.; Mao, Y.; Garg, A.; Park, E. S.; Wu, Y.; Chow, A.; Peregrin, J.; Zhang, X.
10.1101/2024.10.20.619055 — developmental biology — Posted on 2025-02-17
2264 Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Schrott, S.; Gerle, C.; Bibinger, S.; Bertgen, L.; Marino, G.; Schwenkert, S.; Rathberger, R.; Herrmann, J.; Osman, C.
10.1101/2025.02.14.638270 — cell biology — Posted on 2025-02-17
2266 The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules
Gopal, D.; Wu, J.; Delaroche, J.; Bosc, C.; de Andrade, m.; Denarier, E.; Effantin, G.; Andrieux, A.; Gory-Faure, S.; serre, l.; Arnal, I.
10.1101/2025.02.17.638590 — cell biology — Posted on 2025-02-17
2268 MyoFuse: A fully AI-based workflow for automated quantification of skeletal muscle cell fusion in vitro
Lair, B.; Cazorla, C.; Lobeto, A.; Labour, A.; Laurens, C.; Rustan, A. C.; Weiss, P.; Flores Flores, R.; Moro, C.
10.1101/2025.02.17.638596 — cell biology — Posted on 2025-02-17
2269 Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysm
Mohammed, K. A.; Avolio, E.; Alvino, V. V.; Ahmed, E. M.; Rajakaruna, C.; Ghoneim, A.; Elminshawy, A.; Angelini, G. D.; Madeddu, P.
10.1101/2025.02.16.638506 — cell biology — Posted on 2025-02-17
2270 Human pluripotent stem cell-derived intestinal epithelial cells maintain small intestine-specific functions over time, even with repeated cell division
Chen, J.; Kuramochi, S.; Horiuchi, S.; Kawasaki, T.; Kakizaki, H.; Tabata, L.; Kimura, T.; Nakamura, K.; Akutsu, H.; Ishida, S.; Umezawa, A.
10.1101/2025.02.17.638577 — cell biology — Posted on 2025-02-17
2274 Human Brain-Wide Activation of Sleep Rhythms
Wang, H.; Zou, Q.; Zhang, J.; Gao, J.-H.; Liu, Y.
10.1101/2024.10.14.618165 — neuroscience — Posted on 2025-02-17
2275 MOSim: bulk and single-cell multi-layer regulatory network simulator
Monzo, C.; Aguerralde-Martin, M.; Martinez-Mira, C.; Arzalluz, A.; Conesa, A.; Tarazona, S.
10.1101/421834 — bioinformatics — Posted on 2025-02-17
2278 TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
Eickhoff, N.; Janetzko, J.; Padrao, N.; Gregoricchio, S.; Siefert, J. C.; Hoekman, L.; Linder, S.; Bleijerveld, O.; Bergman, A. M.; Zwart, W.
10.1101/2025.02.14.638236 — molecular biology — Posted on 2025-02-17
2282 ERGA-BGE genome of Noah's Ark shell (Arca noae Linnaeus, 1758), a Mediterranean bivalve species
Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Sequencing Team, G.; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Teodori, E.; Duprat, S.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Haggerty, L.; Martin, F.; Bortoluzzi, C.
10.1101/2025.02.10.632159 — genomics — Posted on 2025-02-17
2283 Loss of a morph is associated with asymmetric character release in a radiation of woodland salamanders
Waldron, B. P.; Hantak, M. M.; Watts, E. F.; Uyeda, J. C.; Lemmon, A. R.; Lemmon, E. M.; Guralnick, R. P.; Blackburn, D. C.; Kuchta, S. R.
10.1101/2025.02.12.637668 — evolutionary biology — Posted on 2025-02-17
2284 Bayesian inference of toothed whale lifespans
Ellis, S.; Croft, D. P.; Nielsen, M. L. K.; Franks, D. W.; Weiss, M. N.
10.1101/2023.02.22.529527 — evolutionary biology — Posted on 2025-02-17
2286 Developing heterospecific Sterile Insect Technique for pest control: insights from the spotted wing fly Drosophila suzukii
Cerasti, F.; Cristofaro, M.; Mastrantonio, V.; Scifo, J.; Verna, A.; Canestrelli, D.; Porretta, D.
10.1101/2024.09.05.611447 — ecology — Posted on 2025-02-17
2287 Genomic epidemiology of enteropathogenic Escherichia coli (EPEC) in southwestern Nigeria
Akinlabi, O. C.; Dada, R. A.; Olayinka, A. A.; Oginni-Falajiki, I. O.; Bejide, O. S.; Adewole, P. D.; Thomson, N.; Aboderin, A. O.; Okeke, I. N.
10.1101/2025.02.14.638250 — microbiology — Posted on 2025-02-17
2288 Can we predict sleep health based on brain features? A large-scale machine learning study using UK Biobank
Raimondo, F.; Bi, H.; Komeyer, V.; Kasper, J.; Primus, S. A.; Hoffstaedter, F.; Mandal, S.; Waite, L.; Winkelmann, J.; Oexle, K.; Eickhoff, S.; Tahmasian, M.; Patil, K.
10.1101/2024.10.13.618080 — neuroscience — Posted on 2025-02-17
2289 Rostro-caudal TMS mapping of immediate transcranial evoked potentials reveals a pericentral crescendo-decrescendo pattern
Nuyts, M.; Beck, M. M.; Banach, A.; Thielscher, A.; Meesen, R.; Tomasevic, L.; Siebner, H. R.; Christiansen, L.
10.1101/2025.02.14.638272 — neuroscience — Posted on 2025-02-17
2290 Optimized Protein-Excipient Interactions in the Martini 3 Force Field
Prass, T. M.; Lindorff-Larsen, K.; Garidel, P.; Blech, M.; Schäfer, L. V.
10.1101/2024.11.29.626008 — biophysics — Posted on 2025-02-17
2291 Discovery of a Novel Double-Stranded DNA Virus Reveals its Long-term Co-evolution with Ants
shengqiang, J.; liangliang, Z.; xingyu, G.; jianchao, L.; jing, H.; hong, H.; hongying, C.
10.1101/2025.02.14.638241 — genomics — Posted on 2025-02-17
2293 Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans
Picchetta, L.; Ottolini, C. S.; Tao, X.; Zhan, Y.; Jobanputra, V.; Marin Vallejo, C.; Mulas, F.; Elvezia, E. M.; Escriba Perez, M. J.; Molinaro, T.; Whitehead, C.; Gill, P.; Mounts, E.; Babariya, D.; Rienzi, L. F.; Ubaldi, F. M.; Garcia Velasco, J. A.; Pellicer, A.; Carmi, S.; Hoffmann, E. R.; Capalbo, A.
10.1101/2025.02.15.637872 — genetics — Posted on 2025-02-17
2294 Spatial and single-nucleus transcriptomic profile of a chimpanzee frontal pole
Alagöz, G.; Wong, M.; Grässle, T.; Jäger, C.; Morawski, M.; Kolleck, J.; Francks, C.; Wittig, R. M.; Crockford, C.; Gunz, P.; Fisher, S. E.
10.1101/2025.02.16.638510 — evolutionary biology — Posted on 2025-02-17
2295 Shaping of developmental gradients through selection on multiple loci in Antirrhinum
Bradley, D.; Boell, L.; Richardson, D. M.; Copsey, L.; Whibley, A.; Xu, T.; Zhang, Y.; Xue, Y.; Field, D.; Coen, E.
10.1101/2025.02.12.637738 — evolutionary biology — Posted on 2025-02-17
2297 Phylogenomic analyses reveal that Panguiarchaeum is a clade of genome-reduced Asgard archaea
Huang, W.-C.; Probst, M.; Hua, Z.-S.; Szantho, L. L.; Szollosi, G. J.; Ettema, T.; Rinke, C.; Williams, T. A.; Spang, A.
10.1101/2025.02.13.637844 — evolutionary biology — Posted on 2025-02-17
2300 Mutation and recombination parameters in zebra finch are similar to those in mammals
Prentout, D.; Bykova, D.; Hoge, C. R.; Hooper, D. M.; McDiarmid, C. S.; Wu, F.; Griffith, S.; de Manuel, M.; Przeworski, M.
10.1101/2024.09.05.611523 — evolutionary biology — Posted on 2025-02-17
2301 A subset of conserved phagocytic genes are likely used for the intracellular theft of cnidarian stinging organelles in nudibranch gastropods
Goodheart, J. A.; Fiorenza, R.; Rio, R.; Lopez-Anido, R. N.; Martin, N. J.; Herrlinger, T. J.; Tarvin, R. D.; Lyons, D. C.
10.1101/2025.02.13.637864 — evolutionary biology — Posted on 2025-02-17
2302 Recurrent evolution of cryptic triploids in cultivated enset increases yield
Dussert, Y.; Borrell, J. S.; Stocks, J.; Hunt, H. V.; White, O. W.; Wilkin, P.; Buggs, R.; Buchi, L.; Demissew, S.; Woldeyes, F.; Leitch, I. J.; Abebe, W. M.; Nichols, R. A.
10.1101/2025.02.14.638218 — evolutionary biology — Posted on 2025-02-17
2304 Phylogenomics of Messor harvester ants (Hymenoptera: Formicidae: Stenammini) unravels their biogeographical origin and diversification patterns
Juve, Y.; Weyna, A.; Lauroua, E.; Nidelet, S.; Khaldi, M.; Barech, G.; Lebas, C.; Rasplus, J.-Y.; Cruaud, A.; Condamine, F. L.; Romiguier, J.
10.1101/2025.02.13.638115 — evolutionary biology — Posted on 2025-02-17
2307 Reproductive Adaptation of Astyanax mexicanus Under Nutrient Limitation
Xia, F.; Santacruz, A.; Wu, D.; Bertho, S.; Fritz, E.; Morales-Sosa, P.; McKinney, S.; Nowotarski, S. H.; Rohner, N.
10.1101/2025.02.13.638191 — evolutionary biology — Posted on 2025-02-17
2310 A global effort to benchmark predictive models and reveal mechanistic diversity in long-term stroke outcomes
Matsulevits, A.; Alvez, P.; Atzori, M.; Beyh, A.; Corbetta, M.; Del Pup, F.; Dulyan, L.; Foulon, C.; Hope, T.; Ioannucci, S.; Jobard, G.; Lemaitre, H.; Neville, D.; Nozais, V.; Rorden, C.; Saprikis, O.-V.; Sibon, I.; Sperber, C.; Teghipco, A.; Thirion, B.; Tshimanga, L. F.; Umarova, R.; Vaidelyte, E. B.; van den Hoven, E.; Villar Rodriguez, E.; Zanola, A.; Tourdias, T.; Thiebaut de Schotten, M.
10.1101/2024.10.17.618691 — neuroscience — Posted on 2025-02-17
2312 Planetary-scale marine community modeling predicts metabolic synergy and viral impacts
Regimbeau, A.; Tian, F.; Smith, G.; Riddell, J.; Andreani, C.; Bordron, P.; Budinich, M.; Howard-Varona, C.; Larhlimi, A.; Ser-Giacomi, E.; Trottier, C.; Guidi, L.; Hallam, S. J.; Iudicone, D.; Karsenti, E.; Maass, A.; Sullivan, M. B.; Eveillard, D.
10.1101/2025.02.13.638167 — systems biology — Posted on 2025-02-17
2314 Herbaria provide a valuable resource for obtaining informative mRNA
Tyszka, A. S.; Chia, K.-S.; Bretz, E. C.; Mansour, L.; Larson, D. A.; Carella, P.; Walker, J. F.
10.1101/2025.02.12.637878 — plant biology — Posted on 2025-02-17
2316 Cholangiocytes' Primary Cilia Regulate DNA Damage Response and Repair
Peixoto, E.; Pant, K.; Richard, S.; Abrahante, J. E.; Czaja, W.; Gradilone, S.
10.1101/2025.01.28.635267 — pathology — Posted on 2025-02-17
2317 Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism
Chembo, J.; Bowman, B. M.; Lapak, K.; Wilkerson, E.; Paiboonrungruang, C.; Cho, K.; Medcalf, M. R.; Patti, G.; Dolle, R. E.; Chen, X.; Zolkind, P.; Major, M. B.
10.1101/2025.02.13.637433 — cancer biology — Posted on 2025-02-17
2318 Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C
Jaber, S.; Eldawra, E.; Rakotopare, J.; Simeonova, I.; Lejour, V.; Gabriel, M.; Caneque, T.; Volochtchouk, V.; Licaj, M.; Fajac, A.; Rodriguez, R.; Morillon, A.; Bardot, B.; Toledo, F.
10.1101/2024.09.26.615223 — cancer biology — Posted on 2025-02-17
2320 Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine
Wulffraat, G. C.; Mamathasateesh, S.; Hudson, R.; He, B.; Jara-Oseguera, A.; Senning, E. N.
10.1101/2025.02.14.638348 — biophysics — Posted on 2025-02-17
2322 Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and disease
Dong, W.; Nyame, K.; Rawat, E. S.; Medoh, U. N.; Xiong, J.; Bonin, C. C.; Alsohybe, H. N.; Liu, H. Y.; Gomes, S.; Hsieh, T.; Arnold, M.; Hsieh, F.; Sammler, E.; Abu-Remaileh, M.
10.1101/2025.02.13.638174 — biochemistry — Posted on 2025-02-17
2324 Maximum entropy networks show that plant-arbuscular mycorrhizal fungal associations are anti-nested and modular
Ajaz, S.; Amin, N.; Garcia, A. L.; Birt, H.; Murgo, M. P.; Lanfranco, L.; Garrido, J. L.; Alcantara, J. M.; Rillig, M. C. R.; Johnson, D.; Caruso, T. C.
10.1101/2025.02.14.637838 — ecology — Posted on 2025-02-17
2326 Infections in the Atlantic Blue Crab Callinectes sapidus (Rathbun, 1896) in coastal Adriatic and Aegean sea, and Atlantic Iberian coast
Schott, E.; Scepanovic, M. B.; Lucic, J. M.; Pares, O.; Zhao, M.; Hrabar, J.; Glamuzina, L.; Pecarevic, M.; Grdan, S.; Encarnacao, J. P. d. S.; Morais, P.; Cetkovic, I.; Glamuzina, B.
10.1101/2025.02.14.637520 — ecology — Posted on 2025-02-17
2335 Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models
Bauer, L.; Giussani, S.; Palazzi, N.; Bot, E.; Colombo, E.; Zare, F.; Pinci, F.; Leijten, L.; Lanko, K.; Benavides, F. F. W.; Smeenk, H.; Embregts, C. W. E.; Spoor, J. K. H.; Dirven, C.; Gao, Z.; Bolleboom, A.; Verstrepen, B. E.; Schuele, L.; de Vrij, F. M. S.; Kushner, S. A.; Oude Munnink, B. B.; Davila-Velderrain, J.; van Riel, D.; Harschnitz, O.
10.1101/2023.08.25.554849 — microbiology — Posted on 2025-02-17
2337 Calcium channel-coupled transcription factors facilitate direct nuclear signaling
Rao, E. R.; Thaxton, T.; Gama, E.; Godfrey, J.; Wei, C.; Lin, Q.; Li, Y.; Pastor, D. P. H.; Hansel, C.; Du, X.; Gomez, C. M.
10.1101/2025.02.09.637126 — neuroscience — Posted on 2025-02-17
2338 3BTRON: A Blood-Brain Barrier Recognition Network
Fletcher-Lloyd, N. V.; Bravo-Ferrer, I.; Gaasdal-Bech, K.; Diaz Castro, B.; Barnaghi, P.
10.1101/2025.02.12.637854 — neuroscience — Posted on 2025-02-17
2339 Non-Canonical Role of DNA Mismatch Repair on Sensory Processing in Mice
Oviedo, H. V.; Rahman, S. N.; Neophytou, D.; Oviedo-Gray, S.; Vuong, B. Q.
10.1101/2025.02.13.638164 — neuroscience — Posted on 2025-02-17
2340 The dynamics of explore-exploit decisions suggest a threshold mechanism for reduced random exploration in older adults
Phelps, C. E.; Frisvold, A. E.; Sreeram, M.; Antoniou, V. D.; Oliveira, L. E.; Tooke, S. R.; Lu, Y. Z.; Lemon, A. C.; Fraire, J. U.; Delval, A. G. R.; Smith, B. K.; Spangenberg, D. H.; Mithelavage, M. N.; Ngo, M. N.; Keller, E. M. O.; Isaac, L. J.; Harader, S. A.; Mizell, J.-M.; Wang, S.; Keung, W.; Sundman, M. H.; Franchetti, M.-K.; Choi, Y.-h.; Alexander, G. E.; Wilson, R. C.
10.1101/2025.02.13.638023 — neuroscience — Posted on 2025-02-17
2343 Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy
Li, H.; Xie, Z.; Tian, Y.; Lin, B.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Chen, S.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-02-16
2345 CellSAM: A Foundation Model for Cell Segmentation
Israel, U.; Marks, M.; Dilip, R.; Li, Q.; Yu, C.; Laubscher, E.; Iqbal, A.; Pradhan, E.; Ates, A.; Abt, M.; Brown, C.; Pao, E.; Li, S.; Pearson-Goulart, A.; Perona, P.; Gkioxari, G.; Barnowski, R.; Yue, Y.; Van Valen, D. A.
10.1101/2023.11.17.567630 — bioinformatics — Posted on 2025-02-17
2348 Comparison of Activities of Transcription Factor NF-κB from Two Jellyfish Models
Williams, L. M.; Wang, W.; Grigoryeva, A. V.; Navarro-Rosado, A.; Peart, J. A.; Calderon, A.; Gill, C. L.; Alsante, K. M.; Lackstrom, A. T.; Molecular Biology Laboratory, ; Weissbourd, B.; Wang, M.; DiRusso, C. J.; Cohen, L. B.; Wunderlich, Z.; Grone, B. P.; Gilmore, T. D.
10.1101/2025.01.21.634164 — molecular biology — Posted on 2025-02-16
2349 CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression
Castruita, D. S.; Han, I.; Morgan, R. C.; Carpenter, S.; Williams, B.; Chakraborty, A.; Radhakrishnan, I.; Ay, F.; Myers, S. A.; Rao, A.; Shukla, V.
10.1101/2025.02.03.636329 — molecular biology — Posted on 2025-02-17
2350 A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs
Pitre, E.; Bisht, K.; Remick, K.; Ghorbani, A.; yewdell, j. J. W.; Elshina, E.; te Velthuis, A. J. W.
10.1101/2025.01.04.630666 — microbiology — Posted on 2025-02-16
2352 pH dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis
Nain, V. K.; Barik, V.; Pandey, M.; Pareek, M.; Sharma, T.; Pal, R.; Tyagi, S.; Bajpai, M.; Dwivedi, P.; Panda, B. N.; Kumar, Y.; Asthana, S.; Pandey, A. K.
10.1101/2024.07.28.605477 — microbiology — Posted on 2025-02-16
2353 Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors
Ray, A.; Bassette, M.; Hu, K. H.; Pass, L. F.; Samad, B.; Combes, A.; Johri, V.; Davidson, B.; Hernandez, G.; Zaleta-Linares, I.; Krummel, M. F.
10.1101/2023.09.26.559470 — immunology — Posted on 2025-02-16
2362 Phytoplankton recruitment of specific microbial assemblages and phylosymbiotic patterns
Kim, J.-H.; Kim, J. H.; Li, Z.; Shin, H. H.; Lim, Y. K.; Baek, S. H.; Wang, P.; Park, R. Y.; Jin, S. H.; Han, M.-S.; Park, B. S.
10.1101/2025.02.10.637405 — ecology — Posted on 2025-02-16
2364 Targeted genomic surveillance of insecticide resistance in African malaria vectors
Nagi, S. C.; Lucas, E. R.; Ashraf, F.; Mugoya, T.; Lukyamuzi, E.; Summers, S.; Yee, C. K.; Jacob, C. G.; Nganga, H. N.; Pemberton, T.; Essandoh, J.; Lukindu, M.; Kabore, H.; Sawadogo, G.; Williams, J.; Van t Hof, A. E.; Hernandez-Koutoucheva, A.; Hubbart, C.; Rowlands, K.; Jeffreys, A.; Goodwin, S.; Park, N.; Ariani, C.; Egyir-Yawson, A.; Goncalves, S.; Rajatileka, S.; Rockett, K.; Simpson, V. J.; Miles, A.; Weetman, D.; Kayondo, J.; Nolan, T.; Donnelly, M. J.
10.1101/2025.02.14.637727 — genomics — Posted on 2025-02-16
2365 The MicroMap is a network visualisation resource for microbiome metabolism
Thinnes, C. C.; Waschkowitz, R.; Courtney, E.; Culligan, E.; Fahy, K.; Ferrazza, R. A. M.; Ferris, C.; Lagali, A.; Lane, R.; Maye, C.; Murphy, O.; Noone, D.; Ryan, S.; Bet, M.; Corr, M. C.; Cummins, H.; Hackett, D.; Healy, E.; Kulczycka, N.; Lang, N.; Madden, L.; McHugh, L.; Pyne, I.; Varley, C.; Harkin, N.; Meade, R.; O'Donnell, G.; Nap, B.; Martinelli, F.; Heinken, A.; Thiele, I.
10.1101/2025.02.13.637616 — systems biology — Posted on 2025-02-16
2366 Structural basis of neurofibromin tetramerization and dimer-tetramer equilibrium
Si, S.; Tueting, C.; Lohse, S.; Landfester, K.; Lieberwirth, I.; Kastritis, P. L.; Harder, A.
10.1101/2025.02.13.638105 — molecular biology — Posted on 2025-02-16
2368 Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy
Brothers, B. A.; Sechrest, E. R.; Ma, L.; Ashcraft, M. E.; Guan, T.; Barbera, R. J.; Cahill, M. E.; Shaw, L. M.; Chen, B.; Baehr, W.; Hu, G.; Stoilov, P.; Deng, W.-T.
10.1101/2025.02.14.638316 — molecular biology — Posted on 2025-02-16
2371 Robust constrained weighted least squares for in vivo human cardiac diffusion kurtosis imaging
Coveney, S.; Afzali, M.; Mueller, L.; Teh, I.; Szczepankiewicz, F.; Jones, D. K.; Schneider, J. E.
10.1101/2025.02.12.637822 — physiology — Posted on 2025-02-16
2373 Modeling metabolic disease susceptibility and resilience in genetically diverse mice
Baker, C. N.; Harder, J. M.; Skelly, D. A.; Gaca, M.; Gerdes Gyuricza, I.; Vincent, M.; Ingalls, A.; Keller, M. P.; Attie, A. D.; Braun, M.; Stitzel, M. L.; Liu, E. T.; Rosenthal, N. T.; Churchill, G. A.
10.1101/2025.02.12.637923 — physiology — Posted on 2025-02-16
2375 Pooled screening identifies combinatorial CAR signaling domains for next-generation CAR-M immunotherapies
Wang, Y.; Zuo, S.; Bao, H.; Zhang, Z.; Chen, Y.; Zhang, W.; Liu, Q.; Lu, Y.; Huang, Y.; Zheng, W.; Yang, N.; Ye, L.; Shen, P.
10.1101/2025.02.16.638489 — bioengineering — Posted on 2025-02-16
2377 UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design
Oken, A. C.; Turcu, A. L.; Tzortzini, E.; Georgiou, K.; Nagel, J.; Barniol-Xicota, M.; Kim, G.-R.; Lee, S.-D.; Nicke, A.; Kim, Y.-C.; Müller, C. E.; Kolocouris, A.; Vazquez, S.; Mansoor, S. E.
10.1101/2025.02.12.637899 — biochemistry — Posted on 2025-02-16
2381 An ex vivo and in vitro investigation of extracellular vesicle interactions with B cells of Macaca nemestrina and humans
Pachane, B. C.; Rodriguez, B. V.; Shirk, E. N.; Gololobova, O.; Carlson, B.; Queen, S. E.; Erickson, L. D.; Selistre-de-Araujo, H. S.; Witwer, K. W.
10.1101/2025.02.12.637883 — molecular biology — Posted on 2025-02-16
2382 Programming alphavirus with IFN-γ overrides the adverse effects of macrophages on oncolytic virotherapy
Horvathova, L.; Janzen, T.; Hoogeboom, B. N.; Weissing, F. J.; Daemen, T.; Bhatt, D. K.
10.1101/2025.02.12.637841 — immunology — Posted on 2025-02-16
2383 Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Abeta antibody
Vega, M. R.; Hansen, H. H.; Jensen, C. S.; Alexiou, E.; Madsen, M. R.; Wichern, F.; Skytte, J. L.; Salinas, C. G.; Sotty, F.; Jensen, A.; Vergo, S.; Hecksher-Soerensen, J.
10.1101/2025.02.14.638216 — neuroscience — Posted on 2025-02-16
2387 A Novel Method for Culturing Telencephalic Neurons in Axolotls
Bostan, S.; Serdengecti, S.; Bayat, F. K.; Bay, S.; Sezer, A. S.; Aysit, N.; Ozturk, G.
10.1101/2025.02.14.638296 — neuroscience — Posted on 2025-02-16
2388 Asynchronous viral spread of two unrelated viruses determines Lettuce Big Vein Disease symptom development
Schravesande, W. E. W.; de Heer, P. M.; Heilijgers, M.; Verhage, A.; van den Burg, H. A.
10.1101/2025.02.13.638033 — pathology — Posted on 2025-02-16
2389 Acute obstructive uropathy in male C57Bl/6 mice after general anesthesia with fentanyl, midazolam and medetomidine
Wallace, D. J.; Holmgren, C. D.; Czubayko, U.; Klesing, J.; Martin Machado, D.; Kerr, J. N. D.
10.1101/2025.02.12.636996 — pathology — Posted on 2025-02-16
2390 Estrogen Receptors/E2F1/CDKN3 Axis Protects from UV-induced Skin Cancers in Females
Lukowicz, C.; Winkler, C.; Roger, C.; Fowler, J. C.; Tsai, Y.-C.; Meuli, J.; Claudinot, S.; Chang, Y.-T.; Iselin, C.; Jones, P.; Guenova, E.; Jafari, P.; Michalik, L.
10.1101/2025.02.12.637819 — cancer biology — Posted on 2025-02-16
2392 Tumor suppressor collateral damage screens reveal mRNA homeostasis protein HBS1L as a novel vulnerability in ch9p21 driven FOCAD deleted cancer
Zhang, H.; Tonini, M. R.; Martires, L. C. M.; Pratt, C. B.; Jenkins, H. N.; Gordon, E. N.; Zhao, S.; Choi, A. H.; Meier, S. R.; Khendu, T.; Liu, S.; Shen, B.; Stowe, H.; Pashiardis, K.; Pan, X.; Bandi, M.; Zhang, M.; Yu, Y.; Min, C.; Huang, A.; Andersen, J. N.; Nicholson, H. E.; Teng, T.
10.1101/2025.02.12.637755 — cancer biology — Posted on 2025-02-16
2394 Multiple Xpa In vivo crystallization routes in HEK 293 human cells
Leymarie, O.; Skobelkina, A.; montaville, p.; Brewee, C.; Isabet, T.; Chauvet, H.; Pereiro, E.; Chavas, L. M.; Jamme, F.
10.1101/2025.02.12.637855 — biophysics — Posted on 2025-02-16
2402 Supramolecular assembly of collagen mimetic peptide D-periodic fibrils and nanoassemblies
Cole, C. C.; Kreutzberger, M. A. B.; Klein, K.; Cahue, K. A.; Pogostin, B. H.; Farsheed, A. C.; Swain, J. W. R.; Bui, T. H.; Dey, A.; Makhoul, J.; Dubackic, M.; Pal, A.; Olsson, U.; Saric, A.; Egelman, E. H.; Hartgerink, J. D.
10.1101/2025.02.15.637692 — biochemistry — Posted on 2025-02-16
2404 Discovery of first-in-class inhibitors of the TRF1-TIN2 protein-protein interaction by fragment screening
Casale, G.; Liu, M.; Le Bihan, Y.-V.; Inian, O.; Stammers, E.; Caldwell, J.; van Montfort, R. L. M.; Collins, I.; Guettler, S.
10.1101/2025.02.14.638354 — biochemistry — Posted on 2025-02-16
2407 Odd-chain dicarboxylic acid feeding recapitulates the biochemical phenotype of glutaric aciduria type-1 in mice
Richert, A. C.; Zhang, Y.; Bharathi, S.; Hernandez, A.; Bons, J.; Schilling, B.; Houten, S.; Goetzman, E. S.
10.1101/2025.02.13.637994 — biochemistry — Posted on 2025-02-16
2408 X-ray Spectroscopy Meets Native Mass Spectrometry: Probing Gas-phase Protein Complexes
Kung, J. C. K.; Kadek, A.; Kölbel, K.; Bandelow, S.; Bari, S.; Buck, J.; Caleman, C.; Commandeur, J.; Damjanovic, T.; Dörner, S.; Fahmy, K.; Flacht, L.; Heidemann, J.; Huynh, K.; Kopicki, J.-D.; Krichel, B.; Lockhauserbäumer, J.; Lorenzen, K.; Lu, Y.; Pogan, R.; Rehmann, J.; Schamoni-Kast, K.; Schwob, L.; Schweikhard, L.; Springer, S.; Svensson, P. H. W.; Simke, F.; Trinter, F.; Toleikis, S.; Kierspel, T.; Uetrecht, C.
10.1101/2025.02.14.638288 — biochemistry — Posted on 2025-02-16
2409 A Potent Nonapeptide Inhibitor for the CXCL12/HMGB1 heterocomplex: A Computational and Experimental Approach
Fassi, E. M. A.; Pirani, E.; Cecchinato, V.; Cavalli, A.; Roda, G.; Uguccioni, M.; Sgrignani, J.; Grazioso, G.
10.1101/2025.02.14.638286 — biochemistry — Posted on 2025-02-16
2411 Laboratory yeast strains are highly diverse in lipid metabolism
Renne, M. F.; Brachman, R.; Klose, C. F.; Hentrich, T.; Schultze-Hentrich, J. M.; Ernst, R.
10.1101/2025.02.13.638058 — biochemistry — Posted on 2025-02-16
2413 Decoding RNA-RNA Interactions: The Role of Low-Complexity Repeats and a Deep Learning Framework for Sequence-Based Prediction
Setti, A.; Bini, G.; Maiorca, V.; Pellegrini, F.; Proietti, G.; Miltiadis-Vrachnos, D.; Armaos, A.; Martone, J.; Monti, M.; Ruocco, G.; Rodola, E.; Bozzoni, I.; Colantoni, A.; Tartaglia, G. G.
10.1101/2025.02.16.638500 — biochemistry — Posted on 2025-02-16
2416 Genomic tree scans identify loci underlying adaptive peaks in Antirrhinum
Richardson, D. M.; Bradley, D.; Copsey, L.; Whibley, A.; Burrus, M.; Andalo, C.; Zhu, S.; Field, D.; Xue, Y.; Coen, E.
10.1101/2025.02.12.637406 — evolutionary biology — Posted on 2025-02-16
2418 CRISPR-based shuttle cloning of 1,397 human genes into UAS vectors
Liu, X.; Xi, H.; Dai, M.; Li, X.; Xue, W.; Chen, G.; Yan, J.; Xu, S.; Ou, G.; Luo, S.; Tang, Y.; Wei, P.; Wang, J.
10.1101/2025.02.16.638485 — molecular biology — Posted on 2025-02-16
2419 Mitotic transcription ensures ecDNA inheritance through chromosomal tethering
Nichols, A.; Norman, R. X.; Chen, Y.; Choi, Y.; Striepen, J.; Salataj, E.; Toufektchan, E.; Koche, R. P. X.; Maciejowski, J.
10.1101/2025.02.12.637945 — molecular biology — Posted on 2025-02-16
2420 Activity of Carbazole, Aminoguanidine and Diamine Anti-infectives against Toxoplasma gondii
Singh, D.; Sleda, M. A.; Pandey, A. M.; Malwal, S. R.; Chen, Y.; Zhou, R.; Adewole, F.; Sadowska, K.; Onajole, O. K.; Moreno, S. N. J.; Oldfield, E.
10.1101/2025.02.15.638445 — microbiology — Posted on 2025-02-16
2423 Microsporidia infection alters C. elegans lipid levels
Reinke, A. W.; Burton, N. O.; El Jarkass, H. T.; Jeon, J.
10.1101/2025.02.16.638530 — microbiology — Posted on 2025-02-16
2424 A uniform stress response of stream microbiomes in the hyporheic zone across North America
Stach, T. L.; Starke, J.; Bouderka, F.; Bornemann, T. L. V.; Soares, A. R.; Wilkins, M. J.; Goldman, A. E.; Stegen, J. C.; Borton, M. A.; Probst, A. J.
10.1101/2025.02.16.638492 — microbiology — Posted on 2025-02-16
2425 Microglia Adopt Temporally Specific Subtypes after Irradiation, Correlating with Neuronal Asynchrony
Lastra Romero, A.; Preka, E.; Pizzirusso, G.; Arroyo-Garcia, L. E.; Zisiadis, G. A.; Oliva-Vilarnau, N.; Seitz, T.; Zhou, K.; Gonzalez Isla, A.; Friess, L.; Sun, Y.; Shamikh, A.; Xu, Y.; Zhu, C.; Rodrigues, C.; Fisahn, A.; Joseph, B.; Carlson, L.-M.; Fragkopoulou, A.; Lauschke, V.; Betsholtz, C.; Osman, A.; Blomgren, K.
10.1101/2025.02.15.638339 — neuroscience — Posted on 2025-02-16
2427 A vector-based strategy for olfactory navigation in Drosophila
Siliciano, A. F.; Minni, S.; Morton, C.; Dowell, C. K.; Eghbali, N. B.; Rhee, J. Y.; Abbott, L. F.; Ruta, V.
10.1101/2025.02.15.638426 — neuroscience — Posted on 2025-02-16
2428 Transient Acute Neuronal Activation Response Caused by High Concentrations of Oligonucleotides in the Cerebral Spinal Fluid
Hernandez, M. B.; Mazur, C.; Chen, H.; Fradkin, L.; Searcy, J.; Burel, S.; Kelly, M.; Bruening, D.; O'Rourke, J. G.; Cai, Y.; Nguyen, J.; Berman-Booty, L.; Cummins, L.; Gaus, H.; Powers, B.; Zhao, H.; Jafar-Nejad, P.; Henry, S.; Swayze, E.; Kordasiewicz, H. B.
10.1101/2025.02.13.638138 — neuroscience — Posted on 2025-02-16
2429 Top-down control of the descending pain modulatory system drives placebo analgesia
Livrizzi, G.; Liao, J.; Johnson, D. A.; Lubejko, S. T.; Chang-Weinberg, J.; Dong, C.; Tian, L.; Banghart, M. R.
10.1101/2025.02.13.638185 — neuroscience — Posted on 2025-02-16
2434 Tracing the evolution and genomic dynamics of mating-type loci in Cryptococcus pathogens and closely related species
Coelho, M. A.; David-Palma, M.; Marincowitz, S.; Aylward, J.; Pham, N. Q.; Yurkov, A. M.; Wingfield, B. D.; Wingfield, M. J.; Sun, S.; Heitman, J.
10.1101/2025.02.12.637874 — genetics — Posted on 2025-02-16
2436 Mice dynamically adapt to opponents in competitive multi-player games
Erlich, J. C.; Rastogi, M.; Yin, Q.; Orsolic, I.; Cruz, B. F.; Almeida, A.; Duan, C. A.
10.1101/2025.02.14.638359 — neuroscience — Posted on 2025-02-16
2443 Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture
Kowald, M.; Bachollet, S. P. J. T.; Benseler, F.; Steinecker, M.; Boll, M.; Kaushik, S.; Soykan, T.; Sun, S.; Birke, R.; Ilic, D.; Brose, N.; Hoernberg, H.; Lehmann, M.; Rizzoli, S.; Broichhagen, J.; Lipstein, N.
10.1101/2024.10.08.617143 — neuroscience — Posted on 2025-02-16
2446 p21-activated kinase regulates Rab3a vesicles to repair plasma membrane damage caused by Amyloid-β oligomers
Valappil, D. K.; Veerabhadraswamy, P.; Sarathi, S. P.; Hegde, P.; Gowda, J. M.; Kumar, A.; Gandasi, N. R.; Nath, S.
10.1101/2025.02.11.637764 — cell biology — Posted on 2025-02-16
2447 Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport
Raveh, B.; Eliasian, R.; Rashkovits, S.; Russel, D.; Hayama, R.; Sparks, S.; Singh, D.; Lim, R.; Villa, E.; Rout, M. P.; Cowburn, D.; Sali, A.
10.1101/2023.12.31.573409 — cell biology — Posted on 2025-02-16
2448 Latent activity in TnpB revealed by mutational scanning
Thornton, B. W.-L.; Weissman, R. F.; Tran, R. V.; Duong, B. T.; Rodriguez, J. E.; Terrace, C. I.; Groover, E. D.; Park, J.-U.; Tartaglia, J.; Doudna, J. A.; Savage, D.
10.1101/2025.02.11.637750 — molecular biology — Posted on 2025-02-16
2451 Fast and accurate modeling of TCR-peptide-MHC complexes using tFold-TCR
Wu, F.; Zhao, Y.; Xiao, Y.; Qin, C.; Wang, F.; Wu, Z.; Huang, L.-K.; Liu, X.; Song, J.; He, B.; Rossjohn, J.; Yao, J.
10.1101/2025.01.12.632367 — bioinformatics — Posted on 2025-02-16
2456 Ist2, a protein involved in phosphatidylserine transport, is an ER lipid scramblase
Sebinelli, H. G.; Syska, C.; Razmazma, H.; Albanese, V.; Araujo, A. R. D.; Hilpert, C.; Montigny, C.; Jaxel, C.; Tchamba, M.; Belingar, K.; D'Ambrosio, J. M.; Monticelli, L.; Lenoir, G.; Copic, A.
10.1101/2025.02.13.638165 — cell biology — Posted on 2025-02-16
2460 Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration
Fokin, A. I.; Lin, Y.; Guschin, D. Y.; Chen, H.-Y.; James, J.; Yan, J.; Silberzan, P.; Gautreau, A. M.
10.1101/2025.02.14.638398 — cell biology — Posted on 2025-02-16
2461 Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease
Jacquemyn, J.; Mariott, B.; Chang, J.; Lee, N. Y. J.; Atonal, L. F. R.; Green, C.; Wong, J.; Chik, K.; Acevedo-Morantes, C.; Chen, C. X.- Q.; Nicoleau, M.; You, Z.; Deneault, E.; Abdian, N.; Durcan, T. M.; Jackson, J.; Ioannou, M. S.
10.1101/2025.02.14.638390 — cell biology — Posted on 2025-02-16
2463 Minimizing detection bias of somatic mutations in a highly heterozygous oak genome
Xian, W.; Carbonell-Bejerano, P.; Rabanal, F. A.; Bezrukov, I.; Reymond, P.; Weigel, D.
10.1101/2025.02.13.638107 — genomics — Posted on 2025-02-16
2465 Pex30-dependent membrane contacts sites maintain ER lipid homeostasis
Ferreira, J.; Ahmed, Y.; Heunis, T.; Jain, A.; Johnson, E.; Raeschle, M.; Ernst, R.; Vanni, S.; Carvalho, P.
10.1101/2025.02.12.637848 — cell biology — Posted on 2025-02-16
2468 A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions
Meeusen, B.; Ambjoern, S.; Veis, J.; Riley, R.; Vit, G.; Brauer, B.; Moeller, M.; Greiner, E. C.; Chan, C.; Weisser, M.; Garvanska, D.; Zhu, H.; Davey, N. E.; Kettenbach, A.; Ogris, E.; Nilsson, J.
10.1101/2025.02.12.637884 — cell biology — Posted on 2025-02-16
2469 Dynamic and Biphasic Regulation of Cell Migration by Ras
Lin, Y.; Parajon, E.; Yuan, Q.; Ye, S.; Qin, G.; Deng, Y.; Borleis, J.; Koyfman, A.; Iglesias, P. A.; Konstantopoulos, K.; Robinson, D. N.; Devreotes, P. N.
10.1101/2025.02.13.638204 — cell biology — Posted on 2025-02-16
2470 Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis
Sarkar, S.; Liu, H.-Y.; Yuan, F.; Malady, B. T.; Wang, L.; Perez, J.; Lafer, E. M.; Huibregtse, J.; Stachowiak, J.
10.1101/2025.02.12.637885 — cell biology — Posted on 2025-02-16
2471 Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway
Quintanilla, I.; Azeroglu, B.; Sagar, M. A. K.; Stracker, T. H.; Lazzerini Denchi, E.; Pegoraro, G.
10.1101/2025.02.15.638448 — cell biology — Posted on 2025-02-16
2472 STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence
Vanicek, L. R.; Fischer, A.; Ruz Jurado, M.; Procida-Kowalski, T.; Wilhelm, J.; Merten, M.; Escher, F.; Kattih, B.; Puntmann, V.; John, D.; Nagel, E.; Dimmeler, S.; Luxan, G.
10.1101/2025.02.14.638233 — cell biology — Posted on 2025-02-16
2473 Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Schrott, S.; Gerle, C.; Bibinger, S.; Bertgen, L.; Marino, G.; Schwenkert, S.; Rathberger, R.; Herrmann, J.; Osman, C.
10.1101/2025.02.14.638270 — cell biology — Posted on 2025-02-16
2476 Coro1a promotes the multivesicular body and plasma membrane fusion by facilitating PKM2-mediated SNAP-23 phosphorylation
Cai, z.; Li, Z.; Yan, T.; Fu, B.; He, X.; Li, N.; Wang, C.; Chen, Y.; Zhang, D.; Cai, Z.; Cai, J.; Zhu, W.; Wu, H.
10.1101/2025.02.14.638370 — cell biology — Posted on 2025-02-16
2478 Inducible degradation of endogenous proteins by AlissAID system and development of a photoactivatable inducer.
Ogawa, Y.; Nishimura, K.; Nambo, M.; Tsuchiya, Y.; Oka, S.; Fujimori, T.; Ichihara, K.; Matsumoto, A.; Obara, K.; Kamura, T.
10.1101/2025.02.13.638197 — cell biology — Posted on 2025-02-16
2479 p70S6 kinase-dependent phosphorylation of the μ2 subunit of the AP2 adaptor complex is needed for clathrin-mediated endocytosis.
Tempes, A.; Brzozowska, A.; Wegierski, T.; Olek, K.; Jastrzebski, K.; Liszewska, E.; Misztal, K.; Machnicka, K.; Macias, M.; Szybinska, A.; Sitkiewicz, E.; Gozdz, A.; Wrobel, A.; Miaczynska, M.; Pokrzywa, W.; Jaworski, J.; Malik, A.
10.1101/2025.02.13.638021 — cell biology — Posted on 2025-02-16
2481 Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22
Chi, F.; Zhang, Q.; Shay, J. E. S.; Hoeve, J. T.; Yuan, Y.; Yang, Z.; Shin, H.; Solanki, S.; Shah, Y. M.; Agudo, J.; Yilmaz, O. H.
10.1101/2025.02.15.638423 — cell biology — Posted on 2025-02-16
2483 Partial Input Loss Differentially Modifies Neural Pathways
Lee, J. Y.; Kastner, D. B.; Harris, S. C.; Santina, L. D.; John, J. V.; Stone, N. S.; Dunn, F. A.
10.1101/2025.02.14.638366 — neuroscience — Posted on 2025-02-16
2485 Linguistic coupling between neural systems for speech production and comprehension during real-time dyadic conversations
Zada, Z.; Nastase, S. A.; Speer, S.; Mwilambwe-Tshilobo, L.; Tsoi, L.; Burns, S.; Falk, E.; Hasson, U.; Tamir, D.
10.1101/2025.02.14.638276 — neuroscience — Posted on 2025-02-16
2486 Divergent modulation of dopaminergic neurons by hypocretin/orexin receptors-1 and -2 shapes dopaminergic cell activity and socio-emotional behavior
Tzanoulinou, S.; Astori, S.; Grandi, L. C.; Gullo, F.; Kalusivikako, R.; Rai, S.; Tafti, M.; Becchetti, A.; Vassalli, A.
10.1101/2025.02.14.638329 — neuroscience — Posted on 2025-02-16
2490 A neuro-immune axis of transcriptomic dysregulation within the subgenual anterior cingulate cortex in schizophrenia
Smith, R. L.; Mihalik, A.; Akula, N.; Auluck, P. K.; Marenco, S.; Raznahan, A.; Vertes, P. E.; McMahon, F. J.
10.1101/2025.02.14.638357 — neuroscience — Posted on 2025-02-16
2491 Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development
Ries, C.; Stark, T.; Boulat, B.; Delling, J.-P.; Ruhwedel, T.; Miralles-Infante, A.; von Poblotzki, J.; Ulivi, A.; von Muecke-Heim, I.-A.; Chang, S.; Sakimura, K.; Itoi, K.; Attardo, A.; Nestvogel, D.; Czisch, M.; Nave, K.-A.; Moebius, W.; Dimou, L.; Deussing, J. M.
10.1101/2025.02.14.638041 — neuroscience — Posted on 2025-02-16
2492 The "Podcast" ECoG dataset for modeling neural activity during natural language comprehension
Zada, Z.; Nastase, S. A.; Aubrey, B.; Jalon, I.; Michelmann, S.; Wang, H.; Hasenfratz, L.; Doyle, W.; Friedman, D.; Dugan, P.; Melloni, L.; Devore, S.; Flinker, A.; Devinsky, O.; Goldstein, A.; Hasson, U.
10.1101/2025.02.14.638352 — neuroscience — Posted on 2025-02-16
2493 Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers
Santander, T.; Bekir, S.; Paul, T.; Simonson, J. M.; Wiemer, V. M.; Skinner, H. E.; Hopf, J. L.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.
10.1101/2025.02.14.638327 — neuroscience — Posted on 2025-02-16
2495 Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle
Fan, Y.; Peng, X.; Ebrahimi, M.; Tabassum, N. I.; Cheng, X.; Kumar, Y.; Liu, Y. U.; Chen, G.; Okun, E.; Johns, T. G.; Sobey, C. G.; Lai, M. K. P.; Gunaratne, J.; Mattson, M. P.; Jo, D.-G.; Arumugam, T.
10.1101/2025.02.11.637778 — bioinformatics — Posted on 2025-02-15
2499 Neighbor density-dependent facilitation promotescoexistence and internal oscillation
Buche, L.; Shoemaker, L. G.; Hallett, L.; Vesk, P.; Godoy, O.; Mayfield, M. M.
10.1101/2025.02.11.636978 — ecology — Posted on 2025-02-15
2500 Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies
Bekkering, E. T.; Yoo, R.; Hailemariam, S.; Heide, F.; Ivanochko, D.; Jackman, M.; Proellochs, N. I.; Stoter, R.; Wanders, O. T.; van Daalen, R. C.; Inklaar, M. R.; Andrade, C. M.; Jansen, P. W.; Vermeulen, M.; Bousema, T.; Rubinstein, J. L.; Kooij, T. W.; Jore, M. M.; Julien, J.-P.
10.1101/2025.02.14.638310 — molecular biology — Posted on 2025-02-15
2501 Immune response to co-administration of bovine tuberculosis and contraceptive vaccines in badgers (Meles meles)
Palphramand, K. L.; Anderson, P.; Bellamy, F.; Birch, C. P. D.; Dave, D.; Eckery, D.; Gomm, M.; Jinks, R.; Massei, G.; Pinkham, R.; Rahou, S.; Simmons, H.; Vial, F.; Williams, G. A.; Smith, G. C.
10.1101/2025.02.12.637632 — immunology — Posted on 2025-02-15
2502 Lymph nodes link sex-biased immune aging to compromised antigen recognition
Menzel, L.; Zschummel, M.; O'Melia, M. J.; Zhou, H.; Lei, P.-J.; Liu, L.; Sen, D. R.; Munn, L. L.; Padera, T. P.
10.1101/2025.02.11.637693 — immunology — Posted on 2025-02-15
2504 Inferring Ligand-Receptor Interactions between neuronal subtypes during mouse cortical development
Mathieu, R.; Corbieres, L.; Draia-Nicolau, T.; Govindan, A.; Bensa, V.; Pallesi-Pocachard, E.; Silvagnoli, L.; Represa, A.; Cardoso, C.; Telley, L.; de Chevigny, A.
10.1101/2024.09.02.610245 — neuroscience — Posted on 2025-02-15
2505 ABCG5 ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high cholesterol diet
Anspach, G. B.; Chauhan, I.; Savage, E. L.; Poole, B. R.; Noffsinger, V. P.; Fu, X. M.; Wang, Z.; Temel, R. E.; Gordon, S. M.; Helsley, R. N.; Graf, G. A.
10.1101/2025.02.11.637687 — physiology — Posted on 2025-02-15
2510 APV-Sankey: A Comprehensive Toolbox for Aptamer Screening and Visualization
Zhang, Y.; Wang, Y.; Gao, Y.; Hu, K.; Gong, H.; Jia, H.; Zhang, X.; Lou, X.
10.1101/2025.02.11.637585 — bioinformatics — Posted on 2025-02-15
2515 Competence of DNA Tetrahedron and Exosomes as Nanocarriers for Epirubicin drug delivery in Breast Cancer Cells
Saleem, A.; Saleeem, S.; Gani, U.; Shafi, N.; Vaswani, P.; Dhar, L. A.; Nazir, J.; Ahmad, S. F.; Ahmad, S. M.; Bhatia, D. D.
10.1101/2025.02.11.637654 — bioengineering — Posted on 2025-02-15
2519 p21-activated kinase regulates Rab3a vesicles to repair plasma membrane damage caused by Amyloid-β oligomers
Valappil, D. K.; Veerabhadraswamy, P.; Sarathi, S. P.; Hegde, P.; Gowda, J. M.; KUMAR, A.; Gandasi, N. R.; Nath, S.
10.1101/2025.02.11.637764 — cell biology — Posted on 2025-02-15
2520 Wnt-dependent spatiotemporal reprogramming ofbone marrow niches drives fibrosis
Banjanin, B.; Nagai, J.; Mun, Y.; Fuchs, S.; Snoeren, I.; Boers, J.; Ruiz Tajeda Segura, M.; Tejeda Mora, H.; Galyga, A. K.; Benabid, A.; Sarkis, R.; Naveiras, O.; Rizk, M.; Wolf, M.; Craveiro, R.; Peisker, F.; Stalmann, U.; Pritchard, J.; Ryuo, H.; Alham, N. K.; Weiler, M.; Kiessling, F.; Lammers, T.; Migliaccio, A. R.; Sivaraj, K. K.; Adams, R. H.; Bindels, E.; Gribnau, J.; Royston, D.; Gleitz, H.; Kramann, R.; Nombela-Arrieta, C.; Costa, I.; Schneider, R. K.
10.1101/2025.02.12.637594 — molecular biology — Posted on 2025-02-15
2522 Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis
Bond, A. N.; Orzechowski, M.; Zhang, S.; Ben-Zion, I.; Lemmer, A.; Garry, N.; Lee, K.; Chen, M.; Delano, K.; Gath, E.; Golas, A.; Nietupski, R.; Fitzgerald, M.; Ehrt, S.; Rubin, E. J.; Sassetti, C. M.; Schnappinger, D.; Shoresh, N.; Hunt, D. K.; Gomez, J. E.; Hung, D. T.
10.1101/2025.02.15.638392 — microbiology — Posted on 2025-02-15
2524 Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection
Michno, B. J.; Pooranachandran, N.; Smith, T. C.; Faught, E.; Lipowska, S.; Fenton, A. K.; Meijer, A. H.; Prajsnar, T. K.
10.1101/2025.02.11.637156 — immunology — Posted on 2025-02-15
2525 Heterogeneous T cell response patterns within established clinical phases of Hepatitis B infection revealed through the rapid functional characterization of HBV-specific T cells in whole blood
Le Bert, N.; Koffas, A.; Kumar, R.; Facchetti, F.; Tan, A. T.; Gill, U. S.; Mak, L.-Y.; Stretch, S. W.; Miao, T.; Hariharaputran, S.; Hang, S. K.; Guo, Y.; Chen, Q.; Degasperi, E.; Lampertico, P.; Chow, W. C.; Bertoletti, A.; Kennedy, P. T.
10.1101/2025.02.11.637593 — immunology — Posted on 2025-02-15
2526 Splenic MARCO+ marginal zone macrophages regulate rapid production of MCP-1 and KC but are dispensable for alloantibody generation in response to stored RBCs in a murine model.
Arneja, A.; Salazar, J. E.; Medved, J.; Ratcliffe, S. J.; Smolkin, M. E.; Santhanakrishnan, M.; Stowell, S.; Hudson, K. E.; Zimring, J. C.; Hendrickson, J. E.; Luckey, C. J.
10.1101/2025.02.11.637644 — immunology — Posted on 2025-02-15
2527 Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity
Le Corf, A.; Maesen, S.; Loyer, C.; vazquez, j.; Lauterbur, M. E.; Sareoua, L.; Gray-Sandoval, G.; Cimarelli, A.; Rey, C.; Sudmant, P. H.; Enard, D.; Etienne, L.
10.1101/2025.02.11.637683 — immunology — Posted on 2025-02-15
2528 Swiprosin-1/EFhd2 promotes mitochondrial spare capacity in response to immobilized antigen in B cells via microtubule stabilization
Weckwerth, L.; Tripal, P.; Schmid, B.; Thomas, J.; Himmelreich, A.-K.; Pracht, K.; Urbanczyk, S.; Allnach, H.; Gottwald, A.; Palmisano, R.; Mielenz, D.
10.1101/2025.02.11.637645 — immunology — Posted on 2025-02-15
2530 Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia
Mukherjee, D.; Satyavolu, S.; Thomas, A.; Cioffi, S.; Li, Y.; Chan, E. R.; Wen, K.; Huang, A.; Jain, M.; Dubyak, G.; Nayak, L.
10.1101/2025.02.11.637657 — immunology — Posted on 2025-02-15
2534 Bacterial population dynamics during colonization of solid tumors
Sayin, S.; ElGamel, M.; Rosener, B.; Brehm, M.; Mugler, A.; Mitchell, A.
10.1101/2025.02.11.637537 — systems biology — Posted on 2025-02-15
2539 Peroxisome proliferator-activated receptor gamma (PPARG)-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion
Visker, J. R.; Tseliou, E.; Kyriakopoulos, C. P.; Hamouche, R.; Yin, M.; Ling, J.; Shankar, T.; Kwan, E.; Cedeno-Rosario, L.; Velasco-Silva, J.; Sideris, K.; Kwak, H.; Hillas, Y.; Yannias, E.; Maneta, E.; Srinivasan, H.; Padilla, L.; Polishchuck, G.; Navankasattusas, S.; Tandar, A.; Ducker, G.; Rutter, J.; Hong, T.; Shaw, R.; Lui, C.; Welt, F.; Drakos, S.
10.1101/2025.02.11.637726 — physiology — Posted on 2025-02-15
2543 Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis
Daunesse, M.; Sundaram, V.; Kentepozidou, E.; Connelly, J.; Anderson, C. J.; Liver Cancer Evolution Consortium, ; Lopez-Bigas, N.; Semple, C.; Odom, D. T.; Taylor, M. S.; Roller, M.; Aitken, S. J.; Flicek, P.
10.1101/2025.02.11.637769 — cancer biology — Posted on 2025-02-15
2544 Single Cell Resolution Tracking of Cutaneous T-Cell Lymphoma Reveals Clonal Evolution in Disease Progression
Dorando, H. K.; Andrews, J. M.; Borcherding, N. C.; Quinn, C. C.; Schmidt, J. A.; Khatavkar, O. U.; Aluri, J.; Harmon, M. T.; Watkins, M. P.; Frank, A.; Cooper, M. A.; Musiek, A. M.; Mehta-Shah, N.; Payton, J. E.
10.1101/2025.02.11.637715 — cancer biology — Posted on 2025-02-15
2545 Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progression
Wu, J.; Dai, T.; Li, Z.; Pan, M.; Zhang, W.; Chen, H.; Zheng, G.; Qiao, L.; Lian, Q.; Liu, Y.; Chen, J.
10.1101/2025.02.11.637627 — cancer biology — Posted on 2025-02-15
2546 Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression
Kalfakakou, D.; Cameron, D. C.; Kawaler, E. A.; Tsuda, M.; Wang, L.; Jing, X.; Hajdu, C.; Tamayo, D. L.; Shim, Y.; Ackermann, A.; Weissinger, D.; Zimny, H.; Hernandez, R.; Beier, M.; Dimartino, D.; Meyn, P.; Rice, K.; Selvaraj, S.; Loomis, C.; Heguy, A.; Lund, A. W.; Sears, R. C.; Welling, T. H.; Dolgalev, I.; Tsirigos, A.; Simeone, D. M.
10.1101/2025.02.11.637729 — cancer biology — Posted on 2025-02-15
2547 Few-shot in-context learning with large language models for antibody characterization
FUNG, S.-H.; Zhang, Z.; Wang, R.; Miao, C.; Wong, B. S.-H.; Li, K. Y.; Hong, C.; Zhou, J.; Yip, K. Y.; Tsui, S. K.-W.; Cao, Q.
10.1101/2025.02.11.637772 — bioinformatics — Posted on 2025-02-15
2550 cfDecon: Accurate and Interpretable methylation-based cell type deconvolution for cell-free DNA
Wang, Y.; Li, J.; Li, J.; Yang, S.; Huang, Y.; Liu, X.; Fan, Y.; King, I.; Li, Y.; Li, Y.
10.1101/2025.02.11.637663 — bioinformatics — Posted on 2025-02-15
2551 A Study of Calibration as a Measurement of Trustworthiness of Large Language Models in Biomedical Research
de Oliveira, R.; Garber, M. L.; Gwinnutt, J. M.; Rashidi, E. S.; Hwang, J.-H.; Gilmour, W.; Nanavati, J.; El Abidine, K. Z.; Mack, C. D.
10.1101/2025.02.11.637373 — bioinformatics — Posted on 2025-02-15
2554 Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region
Otsuki, T.; Matsumoto, S.; Fujita, J.; Miyata, T.; Namba, K.; Kanada, R.; Okuno, Y.; Kamada, H.; Ohno, H.; Akiba, H.
10.1101/2025.02.11.637430 — biochemistry — Posted on 2025-02-15
2557 A Novel TRPC6 Mutation Causes Autosomal Dominant FSGS
Bhattacharya, R.; Mou, X.; Leeman, S. M.; Mishra, A.; Kalejaiye, T. D.; Stangl, M.; Silas, D.; Soldano, K.; Sperati, C. J.; Olabisi, O.; Hall, G.; Musah, S.
10.1101/2025.02.11.637765 — genetics — Posted on 2025-02-15
2558 Predicting the responses of the world's bird species to increases in agricultural production
Busana, M.; Phalan, B.; Balmford, A.; Buchanan, G. M.; Butchart, S. H. M.; Eyres, A.; Simkins, A. T.; Williams, D. R.; Ball, T. S.; Berger, I.; Clark, M.; Dicks, L. V.; Fajardo, J.; Green, R. E.; Scott, E.; Donald, P. F.
10.1101/2025.02.11.637664 — ecology — Posted on 2025-02-15
2559 A phototaxis assay to measure sublethal effects of pesticides on bees
Sancho, G.; Albacete, S.; Azpiazu, C.; Sgolastra, F.; Rodrigo, A.; Bosch, J.
10.1101/2025.02.11.637502 — ecology — Posted on 2025-02-15
2563 LDL receptor-mediated endocytosis of Escherichia coli α-hemolysin mediates renal epithelial toxicity
Kuhn, H. W.; Smither, M. R.; Jin, R. J.; Collins, C. A.; Ma, H.; Sina, J.; Gaut, J. P.; Diamond, M. S.; Hunstad, D. A.
10.1101/2025.02.14.638193 — microbiology — Posted on 2025-02-15
2564 Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective Candida-innate immune interaction
Blair, B. A. A.; Bragdon, E.; Dhillon, G.; Baker, N.; Stasiak, L.; Muthig, M.; Miramon, P.; Lorenz, M. C.; Wheeler, R. T.
10.1101/2025.02.14.638315 — microbiology — Posted on 2025-02-15
2567 Robust Prediction of Enzyme Variant Kinetics with RealKcat
Sajeevan, K. A.; Osinuga, A.; B, A.; Ferdous, S.; Shahreen, N.; Noor, M.; Koneru, S.; Santa-Correa, L. M.; Salehi, R.; Chowdhury, N. B.; Calderon-Lopez, B.; Mali, A.; Saha, R.; Chowdhury, R.
10.1101/2025.02.10.637555 — systems biology — Posted on 2025-02-15
2568 The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinaemia
Beaudou, C.; Sionneau, L.; Lomet, D.; Robert, V.; Jarrier-Gaillard, P.; Aucagne, V.; Dardente, H.; Beltramo, M.; Hellier, V.
10.1101/2025.02.10.637587 — physiology — Posted on 2025-02-15
2571 GSLab: Open-Source Platform for Advanced Phasor Analysis in Fluorescence Microscopy
Vallmitjana, A.; Torrado, B.; Durkin, A. F.; Dvornikov, A.; Rajil, N.; Ranjit, S.; Balu, M.
10.1101/2025.02.10.637545 — bioinformatics — Posted on 2025-02-15
2573 Engineering a microfluidic-assisted 3D bioprinting approach for the hierarchical control deposition and compartmentalisation of graded bioinks
Serpe, F.; Iafrate, L.; Bastioli, M.; Marcotulli, M.; Sanchini, C.; De Turris, V.; D'Orazio, M.; Palmisano, B.; Mencattini, A.; Martinelli, E.; Riminucci, M.; Casciola, C. M.; Ruocco, G.; Scognamiglio, C.; Cidonio, G.
10.1101/2025.02.10.637484 — bioengineering — Posted on 2025-02-15
2574 Museums and Zoos: Rapid genetic identification of rare species and practical applications for conservation and systematics in a biodiverse country
Chavez, D. E.; Carrion, J.; Cabezas, M. B.; Reyes-Barriga, D.; Lojan, P.; Mora, D.; Bustamante, M.; Pinto, M.; Jarrin-V, P.
10.1101/2025.02.10.637512 — genetics — Posted on 2025-02-15
2575 Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila
Molina, B.; Rojas, J. J.; El-Mecharrafie, N.; Ratliff, E. P.; Lipinski, M.; Finley, K. D.
10.1101/2025.02.10.637558 — genetics — Posted on 2025-02-15
2576 Phytoplankton recruitment of specific microbial assemblages and phylosymbiotic patterns
Kim, J.-H.; Kim, J. H.; Li, Z.; Shin, H. H.; Lim, Y. K.; Baek, S. H.; Wang, P.; Park, R. Y.; Jin, S. H.; Han, M.-S.; Park, B. S.
10.1101/2025.02.10.637405 — ecology — Posted on 2025-02-15
2578 Triterpenoid CDDO-EA Protects from Hyperglycemia, Hyperinsulinemia, and Obesity by Decreasing Energy Intake
Cantu, A. E.; Rasa, C.; Mito, S.; Cantu, D.; Lopez-Alvarenga, J. C.; Rivera-Lopez, L. L.; Rios, I.; Abrego-Gonzalez, A.; Reyna, S. M.
10.1101/2025.02.12.636924 — molecular biology — Posted on 2025-02-15
2580 Balancing Act: Groundwater microbiome''s resilience and vulnerability to hydroclimatic extremes
Wang, H.; Herrmann, M.; Schroeter, S. A.; Zerfass, C.; Lehmann, R.; Lehmann, K.; Ivanova, A.; Pohnert, G.; Gleixner, G.; Trumbore, S. E.; Totsche, K. U.; Küsel, K.
10.1101/2025.02.14.638306 — microbiology — Posted on 2025-02-15
2582 Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade
Raposo, C. J.; Yan, P. K.; Chen, A. Y.; Majidi, S.; Hiam-Galvez, K. J.; Satpathy, A. T.
10.1101/2025.02.10.637523 — immunology — Posted on 2025-02-15
2583 Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol
hanna, s.; la, k.; Yoshii, Y.; Gits-Muselli, M.; El Meouche, I.; Benhadid-Brahmi, Y.; Bonacorsi, S.; Birgy, A.
10.1101/2025.02.14.638246 — microbiology — Posted on 2025-02-15
2587 NSAID-mediated cyclooxygenase inhibition disrupts ectodermal derivative formation in axolotl embryos
Marshall, E. J.; Ramarapu, R.; Leathers, T. A.; Morrison-Welch, N.; Sandberg, K.; Kawashima, M.; Rogers, C. D.
10.1101/2024.10.30.621122 — developmental biology — Posted on 2025-02-15
2589 Cethromycin Pharmacokinetics and Pharmacodynamics for Single Dose Cure of Plasmodium berghei Liver Stages
Kennedy, G. J.; West, R. M.; Poti, K.; Bobb, B.; Ippolito, M. M.; Marzinke, M. A.; Kaludov, N.; Sullivan, D. J.
10.1101/2025.02.10.637401 — microbiology — Posted on 2025-02-15
2590 Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity
Lopes, S. M.; Lopes, M. M.; Oliveira, D.; Santana, M. M.; Fernandes, A. R.; Vasconcelos-Ferreira, A.; Pereira, D.; Casquinha, M.; Nobrega, C.; Matos, C. A.; Sanjana, N. E.; Hsu, P. D.; Ran, F. A.; Swiech, L.; Cong, L.; Zhang, F.; Nobre, R. J.; de Almeida, L. P.
10.1101/2025.02.14.637261 — neuroscience — Posted on 2025-02-15
2591 Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration
Maddineni, P.; Kodati, B.; Kaipa, B. R.; Kesavan, K.; Millar, C. J.; Yacoub, S.; Kasetti, R. B.; Clark, A. F.; Zode, G. S.
10.1101/2025.02.13.638142 — neuroscience — Posted on 2025-02-15
2592 Lattice ultrasensitivity amplifies signals in E. coli without fine-tuning
Sherry, D. M.; Graf, I. R.; Bryant, S. J.; Emonet, T.; Machta, B. M.
10.1101/2024.05.28.596300 — biophysics — Posted on 2025-02-15
2595 Addressing efficacy of everyday hygiene cleansing products in context of sustainable handwashing behavior in the post-pandemic era
Pathak, S. B.; Arora, S.; Trivedi, U.; Sherin, L.; Sayyed, J.; Kumar, N.; Jayasekera, H. W.; Majumdar, A.; Mukherjee, S.
10.1101/2025.02.13.638075 — microbiology — Posted on 2025-02-15
2596 Nucleocytoviricota viral factories are transient organelles made by liquid-liquid phase separation
Rigou, S.; Schmitt, A.; Moreno, A. B.; Lartigue, A.; Danner, L.; Giry, C.; Trabelsi, F.; Belmudes, L.; Olivero-Deibe, N.; Le Guenno, H.; Coute, Y.; Berois, M.; Legendre, M.; Jeudy, S.; Abergel, C.; Bisio, H.
10.1101/2024.09.01.610734 — microbiology — Posted on 2025-02-15
2599 p16 expression confers sensitivity to CDK2 inhibitors
Sine, C.; Watts, L.; Fernandez, B.; Wang, J.; Knudsen, E.; Witkiewicz, A.; Spencer, S. L.
10.1101/2025.02.10.637344 — cancer biology — Posted on 2025-02-15
2600 Suppression of Ovarian Cancer Cell Proliferation is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin.
Farsinejad, S.; Centeno, D.; Carstens, J.-S.; Polotaye, T.; Pavlovic, T.; Babvey, P.; Muranen, T.; Muranen, T.; Lum, P. Y.; Martin, L. A.; Iwanicki, M. P.
10.1101/2025.02.10.637535 — cancer biology — Posted on 2025-02-15
2604 Bclaf1 biomolecular condensates protect nuclear PTK2 from ubiquitin-proteasome system promoting cardiomyocyte survival during oxidative stress
Aparecida Moretto, I.; Rodrigues, B. R. I.; Victor-Carvalho, P.; Carvalho, M. d. G. d. S.; Silva, M. C. d.; Valdivieso-Rivera, F. B.; Araujo, G. L. d.; Samogim, A. P.; Novais, L. B.; de Brito, I. R.; Reis-de-Oliveira, G.; Amaral, A. G.; Baratti, M. O.; Basei, F. L.; Geraldo, M. V.; Carvalho, P. C.; Santos, M. D. M.; Duran, R.; Sponton, C.; Kobarg, J.; Gozzo, F. C.; Carvalho, H. F.; Thomaz, A. A. d.; Santos, A. M. d.
10.1101/2025.02.04.636487 — cell biology — Posted on 2025-02-15
2606 The Landscape of Prostate Tumour Methylation
Arbet, J.; Yamaguchi, T. N.; Shiah, Y.-J.; Hugh-White, R.; Wiggins, A.; Oh, J.; Gebo, T.; Foucal, A.; Lesurf, R.; Jung, C.-H.; Dang, R. M. A.; Agrawal, R.; Livingstone, J.; Salcedo, A.; Yao, C. Q.; Espiritu, S. M. G.; Houlahan, K. E.; Yousif, F.; Heisler, L. E.; Fraser, M.; Kishan, A.; Berlin, A.; Chua, M. L.; van der Kwast, T.; Hovens, C. M.; Bristow, R. G.; Boutros, P. C.
10.1101/2025.02.07.637178 — cancer biology — Posted on 2025-02-15
2607 Characterization of transcriptomic changes across Coccidioides morphologies using RiboMarker(R)-enhanced RNA sequencing
Howard, J. M.; Manning, A. C.; Clark, R. C.; Williams, T.; Nobile, C. J.; Kazakov, S.; Barberan-Soler, S.
10.1101/2025.02.11.634332 — molecular biology — Posted on 2025-02-15
2608 Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Campbell, J. M.; Cowan, R. L.; Wahlstrom, K. L.; Hollearn, M. K.; Jensen, D.; Davis, T.; Rahimpour, S.; Shofty, B.; Arain, A.; Rolston, J. D.; Hamann, S.; Wang, S.; Eisenman, L. N.; Swift, J.; Xie, T.; Brunner, P.; Manns, J. R.; Inman, C. S.; Smith, E. H.; Willie, J. T.
10.1101/2024.11.11.622161 — neuroscience — Posted on 2025-02-15
2612 GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Austin, G.; Oqua, A. I.; ElEid, L.; Zhu, M.; Manchanda, Y.; Peres, P.; Coyle, H.; Poliakova, Y.; Bouzakri, K.; Montoya, A.; Withers, D. J.; Solimena, M.; Jones, B.; Millership, S. J.; Burgold, S.; Gaboriau, D.; Majorovits, E.; Prokopenko, I.; Nixon-Abell, J.; Muller, A.; Tomas, A.
10.1101/2024.04.28.591531 — cell biology — Posted on 2025-02-15
2613 T-cells specific for KSHV and HIV migrate to Kaposi sarcoma tumors and persist over time
Ravishankar, S.; Towlerton, A. M. H.; Tiamiyu, I. L.; Mooka, P.; Nankoma, J.; Kafeero, J.; Mubiru, D.; Sekitene, S.; Aicher, L. D.; Miller, C. P.; Coffey, D. G.; Okoche, L.; Atwinirembabazi, P.; Okonye, J.; White, J.; Koelle, D. M.; Jing, L.; Phipps, W. T.; Warren, E. H.
10.1101/2024.02.06.579223 — immunology — Posted on 2025-02-15
2615 The effects of reliable social feedback on language learning: insights from EEG and pupillometry
Zappa, A.; Osokina, P.; Cerda-Company, X.; Cucurell, D.; Mateu, M.; Rodriguez-Fornells, A.
10.1101/2025.02.04.636399 — neuroscience — Posted on 2025-02-15
2617 Transcriptional shifts and microbiome dynamics in sorghum roots during vegetative growth under drought stress
Kabir, A. H.; Brailey-Jones, P.; Abdelrahman, M.; Legeay, J.; Ahmed, B.; Tran, L.-S. P.; Bennetzen, J. L.
10.1101/2024.07.19.604343 — plant biology — Posted on 2025-02-15
2618 Acute kidney injury triggers hypoxemia by inducing intravascular neutrophil retention that reduces lung capillary blood flow
Komaru, Y.; Ning, L.; Lama, C.; Suresh, A.; Kefaloyianni, E.; Miller, M. J.; Kawana, S.; Shepherd, H. M.; Li, W.; Kreisel, D.; Herrlich, A.
10.1101/2024.02.27.582396 — physiology — Posted on 2025-02-15
2620 VASCilia (Vision Analysis StereoCilia): A Napari Plugin for Deep Learning-Based 3D Analysis of Cochlear Hair Cell Stereocilia Bundles
Kassim, Y. M.; Rosenberg, D. B.; Das, S.; Huang, Z.; Rahman, S.; Al Shammaa, I.; Salim, S.; Huang, K.; Renero, A.; Miller, C.; Ninoyu, Y.; Friedman, R. A.; Indzhykulian, A. A.; Manor, U.
10.1101/2024.06.17.599381 — bioinformatics — Posted on 2025-02-15
2621 A forward-engineered muscle tissue driven soft robotic swimmer
Drennan, W. C.; Aydin, O.; Emon, B.; Li, Z.; JOY, M. S. H.; Barishman, A.; Kim, Y.; Wei, M.; Denham, D.; Carrillo, A.; Saif, M. T. A.
10.1101/2024.10.30.621139 — bioengineering — Posted on 2025-02-15
2622 Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Abramsson, M. L.; Corey, R. A.; Skerle, J. L.; Persson, L. J.; Anden, O.; Oluwole, A. O.; Howard, R. J.; Lindahl, E.; Robinson, C. V.; Strisovsky, K.; Marklund, E. G.; Drew, D.; Stansfeld, P. J.; Landreh, M.
10.1101/2024.05.27.592301 — biochemistry — Posted on 2025-02-15
2624 mirror determines the far posterior domain in butterfly wings
Chatterjee, M.; Yu, X. Y.; Brady, N. K.; Amendola, C. A.; Hatto, G. C.; Reed, R.
10.1101/2024.02.15.580576 — evolutionary biology — Posted on 2025-02-15
2627 Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder
Song, B. J.; Ge, Y.; Nicolella, A.; Kwon, M. J.; Lodder, B.; Bonanno, K.; Valle-Tojeiro, A.; Mandell, K. P.; Adeleye, J.; Geng, C.; Natarajan, S.; Picard, I.; Shepard, N.; Aryal, S.; Farsi, Z.; Liu, X.-M.; Morshed, N.; Nadaf, N. M.; Pribiag, H.; Simmons, S. K.; Mani, D. R.; Stevens, B.; Macosko, E. Z.; Levin, J. Z.; Sabatini, B. L.; Keshishian, H.; Carr, S. A.; Dejanovic, B.; Granger, A. J.; Sheng, M.
10.1101/2024.09.24.614783 — neuroscience — Posted on 2025-02-15
2628 The information bottleneck as a principle underlying multi-area cortical representations during decision-making
Kleinman, M.; Wang, T.; Xiao, D.; Feghhi, E.; Lee, K.; Carr, N.; Li, Y.; Hadidi, N.; Chandrasekaran, C.; Kao, J.
10.1101/2023.07.12.548742 — neuroscience — Posted on 2025-02-15
2633 Combined physical and pharmaceutical anabolic osteoporosis therapies synergistically increase bone response and local mechanoregulation
Schulte, F. A.; Griesbach, J. K.; Weigt, C.; von Salis-Soglio, M.; Lambers, F. M.; Marques, F. C.; Kneissel, M.; Richards, P. J.; Kuhn, G. A.; Mueller, R.
10.1101/2024.05.16.594551 — bioengineering — Posted on 2025-02-15
2634 Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces
Rajeeva Pandian, N. K.; Farell, A. M.; Davis, E. E.; Sundaram, S.; van Steen, A. C. I.; Teo, J. L. C.; Eyckmans, J.; Chen, C. S.
10.1101/2024.02.28.582152 — bioengineering — Posted on 2025-02-15
2635 SpaceBar enables clone tracing in spatial transcriptomic data
Kinsler, G.; Fagan, C.; Li, H.; Kaster, J.; Dunne, M.; Vander Velde, R. J.; Boe, R. H.; Shaffer, S.; Herlyn, M.; Raj, A.; Heyman, Y.
10.1101/2025.02.10.637514 — genomics — Posted on 2025-02-14
2636 Changes of cell-type diversity in the polyp-to-medusa metagenesis of the scyphozoan jellyfish Aurelia coerulea (formerly sp.1)
Link, O.; Jahnel, S. M.; Janicek, K.; Kraus, J.; Montenegro, J. D.; Zimmerman, B.; Wick, B.; Technau, U.; Cole, A. G.
10.1101/2023.08.24.554571 — evolutionary biology — Posted on 2025-02-15
2638 P66Shc Mediates SUMO2-induced Endothelial Dysfunction
Kumar, J.; Uppulapu, s. K.; Kumari, S.; Sharma, K.; Paradee, W. J.; Yadav, R. P.; Kumar, V.; Kumar, S.
10.1101/2024.01.24.577109 — cell biology — Posted on 2025-02-15
2639 Dnmt3a-mediated de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells
Perkins, B.; Novis, C.; Baessler, A.; Sircy, L. M.; Thomas, M. M.; Richens, A. W.; Fuchs, B.; Nguyen, N. X.; Fint, K.; Strobelt, B. M.; Varley, K. E.; Hale, J. S.
10.1101/2024.12.03.623450 — immunology — Posted on 2025-02-15
2644 MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts
Lefebvre, C. C.; Giowachini, P.; Derrien, J.; Naour, M.; Corre, I.; Douillard, E.; Guillonneau, F.; Campone, M.; Juin, P. P.; Souaze, F.
10.1101/2025.02.10.637434 — cancer biology — Posted on 2025-02-15
2646 Integration and querying of multimodal single-cell data with PoE-VAE
Litinetskaya, A.; Schulman, M.; Curion, F.; Szalata, A.; Omidi, A.; Lotfollahi, M.; Theis, F. J.
10.1101/2022.03.16.484643 — bioinformatics — Posted on 2025-02-15
2650 Decoding auditory working memory load from EEG alpha oscillations
Yuan, Y.; Gayet, S.; Wisman, D. C.; Van der Stigchel, S.; van der Stoep, N.
10.1101/2025.02.14.638227 — neuroscience — Posted on 2025-02-14
2651 Zebra finches produce intralaryngeal laminar flow whistles during panting
Anttonen, T.; Loning, H.; Felbo, F. M.; Christensen-Dalsgaard, J.; Griffith, S. C.; Naguib, M.; Elemans, C. P.
10.1101/2025.02.14.638254 — physiology — Posted on 2025-02-14
2652 CHD3 regulates BMP signalling response during cranial neural crest cell specification
Mitchell, Z. H.; Den Hoed, J.; Claassen, W.; Demurtas, M.; Deelen, L.; Campeau, P. M.; Liu, K.; Fisher, S. E.; Trizzino, M.
10.1101/2025.02.14.638260 — developmental biology — Posted on 2025-02-14
2653 Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion
Lee, U.; Laguillo-Diego, A.; Wong, W.; Ni, Z.; Cheng, L.; Li, J.; Pelham-Webb, B.; Pertsinidis, A.; Leslie, C. S.; Apostolou, E.
10.1101/2025.02.13.638153 — molecular biology — Posted on 2025-02-14
2656 Role of the NuRD complex and altered proteostasis in cancer cell quiescence
Jiang, Q. J.; Ertel, M.; Arrigo, A.; Sannino, S.; Goeckeler-Fried, J. L.; Sagan, A.; Varghese, B. A.; Brown, D. D.; Stallaert, W.; Lee, A.; Clark, A.; Brodsky, J.; Osmanbeyoglu, H. U.; Buckanovich, R. J.
10.1101/2025.02.10.637435 — cancer biology — Posted on 2025-02-14
2664 Bacteria break through one-micrometer-square passages by flagellar wrapping
Yoshioka, A.; Shimada, Y. Y.; Omori, T.; Uemura, N. A.; Takeshita, K.; Ishigami, K.; Morimura, H.; Furubayashi, M.; Kan, T.; Wada, H.; Kikuchi, Y.; Nakane, D.
10.1101/2025.02.12.637796 — microbiology — Posted on 2025-02-14
2665 Identification of DOK2 and PTPN11 as novel interactors of T cell specific adapter protein TSAd
Chan, H.; Borowicz, P.; Gilmour, B. C.; Stensland, M.; Garcia-Loza, I.; Phuyal, S.; Marone, R.; Jeker, L.; Nyman, T. A.; Spurkland, A.
10.1101/2025.02.11.636929 — immunology — Posted on 2025-02-14
2668 EEG Microstates reveal distinct network dynamics in lucid and non-lucid REM sleep
Wang, X.; Peters, E.; Strelen, J.; Lockhart, N.; Franklin, M.; LaBerge, S.; Koenig, T.; Dresler, M.; Erlacher, D.
10.1101/2025.02.12.637792 — neuroscience — Posted on 2025-02-14
2669 Nitrous oxide modulates cortical activity, wake-sleep oscillations, and produces antidepressant-like effects in mice
Kohtala, S.; Parekh, P. K.; Baramaki, I.; Kohtala, P.; Ilkka, L.; Antila, H.; Lee, F. S.; Liston, C.
10.1101/2025.02.13.638096 — neuroscience — Posted on 2025-02-14
2670 Implicit Emotional Biases in Anxiety and Depression: A Fast Periodic Visual Stimulation Study
Vandenheever, D.; Davidson, H.; Kemp, J.; Murphy, Z.; Kujawa, A.; Shi, C.; Nadorff, M.; Bates-Brantley, K.; Sidwell, M.
10.1101/2025.02.14.638323 — neuroscience — Posted on 2025-02-14
2671 CRISPR/Cas9-mediated elimination of the LMNA c.745C>G pathogenic mutation enhances survival and cardiac function in LMNA-associated congenital muscular dystrophy
Gomez-Dominguez, D.; Epifano, C.; Hernandez, I.; Vilaplana-Marti, B.; Cesar, S.; de Molina, A.; Sena-Esteves, M.; Sarquella-Brugada, G.; Perez de Castro, I.
10.1101/2025.02.13.638060 — bioengineering — Posted on 2025-02-14
2673 Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology
Mellon, W. J.; Sterner, B.; Agren, A.; Vincze, O.; Marx, M. T.; Kapsetaki, S. E.; Huang, P.-H.; Yavari, B.; McCollum, H. W.; Horowitz, B. N.; Human, H.; Baciu, C.; Richker, H.; Mallo, D.; Maley, C. C.; Harmon, L.; Compton, Z. T.
10.1101/2025.02.11.637459 — evolutionary biology — Posted on 2025-02-14
2674 DDX5 and DDX17 RNA helicases regulate hepatitis B virus RNA splicing
Giraud, G.; Grand, X.; Huchon, P.; Roda, M.; Diederichs, A.; Chapus, F.; De Nicola, F.; Parent, R.; Rivoire, M.; Bourgeois, C. F.; Zoulim, F.; Testoni, B.
10.1101/2025.02.14.638243 — molecular biology — Posted on 2025-02-14
2675 Identification of polyphosphate-binding proteins in E. coli uncovers targets involved in translation control and ribosome biogenesis
Baijal, K.; Kore, B.; Abramchuck, I.; Denoncourt, A.; Han, S.; Simms, A.; Dagenais, A.; Long, A. R.; Rudner, A. D.; Lavallee-Adam, M.; Gray, M. J.; Downey, M.
10.1101/2025.02.12.637445 — molecular biology — Posted on 2025-02-14
2678 The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux
Rojas-Palomino, J.; Velazquez, C.; Altuna-Alvarez, J.; Gonzalez-Magana, A.; Zabala-Zearreta, M.; Müller, M.; Queralt-Martin, M.; Alcaraz, A.; Albesa-Jove, D.
10.1101/2025.02.14.638235 — microbiology — Posted on 2025-02-14
2680 Systematic Metaproteomics Mapping Reveals Functional and Ecological Landscapes of Human Gut Microbiota Responses to Therapeutic Drugs
Li, L.; Simopoulos, C. M. A.; Mayne, J.; Ning, Z.; Zhang, X.; Hamada, M.; Butcher, J.; Serrana, J. M.; Wang, L.; Cheng, K. M.; Qin, H.; Walker, K.; ZHANG, X.; Stintzi, A.; Figeys, D.
10.1101/2025.02.13.637346 — microbiology — Posted on 2025-02-14
2687 Single-nucleus analysis of thoracic perivascular adipose tissue reveals critical changes in cell composition, communication, and gene regulatory networks induced by a high fat hypertensive diet
Terrian, L.; Thompson, J. M.; Bowman, D. E.; Panda, V.; Contreras, G. A.; Rockwell, C. E.; Sather, L.; Fink, G. D.; Lauver, D. A.; Nault, R.; Watts, S. W.; Bhattacharya, S.
10.1101/2025.02.13.636878 — bioinformatics — Posted on 2025-02-14
2688 Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Dietrich, M.; Chmielewski, J.; Chan, L.-J.; Tan, L. L.; Adair, A.; Lyons, F.; Gabriela, M.; Lopaticki, S.; Dite, T.; Dagley, L.; Pazzagli, L.; Gupta, P.; Kamil, M.; Vaughan, A. M.; Rojrung, R.; Abraham, A.; Mazhari, R.; Longley, R. J.; Zeglinski, K.; Gouil, Q.; Mueller, I.; Fabb, S.; Shandre-Mugan, R.; Pouton, C. W.; Glukhova, A.; Shakeel, S.; Tham, W.-H.
10.1101/2025.02.13.638205 — microbiology — Posted on 2025-02-14
2689 Bacterial Conjugation in the Ruminant Pathogen Mycoplasma agalactiae is Influenced by Eukaryotic Host Factors
Derriche, M.; Nouvel, L.-X.; Gaudino, M.; Sagne, E.; Simon, E.; Robert, H.; Pot, G.; Meyer, G.; de la Fe Rodriguez, C.; Arfi, Y.; Maillard, R.; Citti, C.; Baranowski, E.
10.1101/2025.02.14.638229 — microbiology — Posted on 2025-02-14
2691 NF-κB dependent gene expression and plasma IL-1β, TNFα and GCSF drive transcriptomic diversity and CD4:CD8 ratio in people with HIV on ART.
Wang, Y.; Gornalusse, G.; Siegel, D.; Barbehenn, A.; Hoh, R.; Martin, J.; Hecht, F.; Pilcher, C.; Semenova, L.; Murdoch, D. M.; Margolis, D. M.; Levy, C. N.; Jerome, K. R.; Rudin, C. D.; Hladik, F.; Deeks, S. G.; Lee, S. A.; Browne, E. P.
10.1101/2025.02.14.638232 — microbiology — Posted on 2025-02-14
2692 The give and take in photosymbiosis unraveled by metabolomics of Radiolaria
Nikitashina, V.; Bartels, B.; Mansour, J. S.; leKieffre, c.; Decelle, J.; Hertweck, C.; Not, F.; Pohnert, G.
10.1101/2025.02.14.638264 — microbiology — Posted on 2025-02-14
2693 Human Papilloma Virus does not fully inactivate p53 in HNSCC
Gencel-Augusto, J.; Li, H.; Woerner, L. C.; Borah, A. A.; Myers, J. N.; Johnson, D. E.; Grandis, J. R.
10.1101/2025.02.11.637252 — cancer biology — Posted on 2025-02-14
2695 Unraveling the Co-Morbidity between COVID-19 and Neurodegenerative Diseases Through Multi-scale Graph Analysis: A Systematic Investigation of Biological Databases and Text Mining
Babaiha, N. S.; Geissler, S.; Nibart, V.; Atas Guevenilir, H.; Bharadhwaj, V. S.; Tom Kodamullil, A.; Klein, J.; Jacobs, M.; Hofmann-Apitius, M.
10.1101/2025.02.13.637069 — bioinformatics — Posted on 2025-02-14
2696 Accurate Somatic SV detection via sequence graph model-based local pan-genome optimization
Tu, K.; Zhang, Q.; Li, Y.; Li, Y.; Yuan, L.; Tang, J.; Xia, L.; Huang, W.; Xie, D.
10.1101/2025.02.11.636543 — bioinformatics — Posted on 2025-02-14
2697 MYRF is Essential in Mesothelial Cells to Promote Lung Development and Maturation
Luna, G.; Verheyden, J.; Tan, C.; Kim, E.; Hwa, M.; Sahi, J.; Shen, Y.; Chung, W.; McCulley, D.; Sun, X.
10.1101/2025.02.13.635155 — developmental biology — Posted on 2025-02-14
2699 SA55 broadly neutralizes SARS-CoV-2 and robustly prevents viral escape by JN.1 sublineages
Shi, L.; Bowen, A.; Han, J.; Zheng, X.; Luo, H.; Yao, T.; Guo, M.; Yu, Y.; Jian, F.; Cao, Y. R.; ke, l.; Guo, Y.; Liu, L.
10.1101/2025.02.12.638008 — microbiology — Posted on 2025-02-14
2701 mRNA-LNP vaccines against Hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models
Limeres, M. J.; Gambaro, R.; Svensson, M.; Fraude-El Ghazi, S.; Pretsch, L.; Frank, D.; Islan, G. A.; Rivero Berti, I.; Bros, M.; Tam, Y. K.; Muramatsu, H.; Pardi, N.; Gehring, S.; Cacicedo, M. L.
10.1101/2025.02.12.636533 — immunology — Posted on 2025-02-14
2702 Magnetoencephalography Reveals Neuroprotective Effects of COVID-19 Vaccination in Non-Human Primates
Stapleton-Kotloski, J.; Rowland, J.; Davenport, A.; Epperly, P.; Blevins, M.; Godwin, D.; Ewing, D.; Liang, Z.; Sundaram, A. K.; Petrovsky, N.; Porter, K.; Gamble, C. S.; Sanders, J. W.; Daunais, J.
10.1101/2025.02.14.638187 — neuroscience — Posted on 2025-02-14
2703 TGIF2 is a major regulator of neural stem cell fate and neurogenic priming
Li, Y.; Krontira, A.; Vierl, F.; Richter, M. L.; Wang, W.; Merl-Pham, J.; Theis, F. J.; Hauck, S. M.; Goetz, M.
10.1101/2025.02.13.635953 — neuroscience — Posted on 2025-02-14
2704 Transcranial Magnetic Stimulation Reduces Non-Decision Time in Perceptual Decisions
Gordleeva, S.; Maksimenko, V.; Mohammad, U.; Grigoriev, N.; Savosenkov, A.; Kuc, A.; Kurkin, S.; Udoratina, A.; Grubov, V.; Hramov, A.
10.1101/2025.02.13.637859 — neuroscience — Posted on 2025-02-14
2707 Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment
Yin, T.; Wang, G.; Ma, Z.; Wang, L.; Chen, R.; Xiang, K.; Tan, L.; Wang, Y.; Chong, M.; Liang, Y.; Pan, C. C.; Alexander, P. B.; Lim, B. J. W.; Wang, E.; Liu, B.; Yan, C.; Li, Q.-J.; Wang, X.-F.
10.1101/2025.02.10.637339 — cancer biology — Posted on 2025-02-14
2711 Developing Foundation Models for Predicting Viral Animal Host Range in Intelligent Surveillance
Guo, J.; Guo, Q.; Yin, H.; Han, Y.; Geng, P. X.; Hou, J.; Zhang, H.; Tan, J.; Li, M.; Zhang, Y.; Jiang, X.; Zhu, H.
10.1101/2025.02.13.638012 — bioinformatics — Posted on 2025-02-14
2713 A metagenomic approach to One Health surveillance of antimicrobial resistance in a UK veterinary centre
Elton, L.; Mateos, A. D.; Frosini, S. M.; Jepson, R.; Rofael, S.; McHugh, T. D.; Wey, E. Q.
10.1101/2025.02.12.636430 — genomics — Posted on 2025-02-14
2715 Characterization of transcriptomic changes across Coccidioides morphologies using RiboMarker(R)-enhanced RNA sequencing
Howard, J. M.; Manning, A. C.; Clark, R. C.; Williams, T.; Nobile, C. J.; Kazakov, S.; Barberan-Soler, S.
10.1101/2025.02.11.634332 — molecular biology — Posted on 2025-02-14
2717 Addressing efficacy of everyday hygiene cleansing products in context of sustainable handwashing behavior in the post-pandemic era
Mukherjee, S.; Pathak, S. B.; Arora, S.; Trivedi, U.; Sherin, L.; Sayyed, J.; Kumar, N.; Majumdar, A.; Jayasekera, H. W.
10.1101/2025.02.13.638075 — microbiology — Posted on 2025-02-14
2721 Deep generation of personalized connectomes based on individual attributes
Liu, Y.; Seguin, C.; Mansour L., S.; Tian, Y.; Di Biase, M. A.; Zalesky, A.
10.1101/2025.02.12.637986 — neuroscience — Posted on 2025-02-14
2722 A versatile miniature two-photon microscope enabling multicolor deep-brain imaging
Wu, R.; Zhao, C.; Qiu, S.; Zhu, Y.; Zhang, L.; Fu, Q.; Hu, Y.; Wu, D.; Yu, F.; Zhou, F.; Huang, H.; Zhang, Y.; Wang, X.; Wang, A.; Cheng, H.
10.1101/2025.02.13.635171 — neuroscience — Posted on 2025-02-14
2723 Identification of a multi-omics factor predictive of long COVID in the IMPACC study
Gabernet, G.; Maciuch, J.; Gygi, J. P.; Moore, J. F.; Hoch, A.; Syphurs, C.; Chu, T.; Jayavelu, N. D.; Corry, D. B.; Kheradmand, F.; Baden, L. R.; Sekaly, R.-P.; McComsey, G. A.; Haddad, E. K.; Cairns, C. B.; Rouphael, N.; Fernandez-Sesma, A.; Simon, V.; Metcalf, J. P.; Agudelo Higuita, N. I.; Hough, C. L.; Messer, W. B.; Davis, M. M.; Nadeau, K. C.; Pulendran, B.; Kraft, M.; Bime, C.; Reed, E. F.; Schaenman, J.; Erle, D. J.; Calfee, C. S.; Atkinson, M. A.; Brackenridge, S. C.; Melamed, E.; Shaw, A. C.; Hafler, D. A.; Ozonoff, A.; Bosinger, S. E.; Eckalbar, W.; Maecker, H. T.; Kim-Schulze, S.;
10.1101/2025.02.12.637926 — systems biology — Posted on 2025-02-14
2725 Evolution of cross-tolerance to metals in yeast
Bazzicalupo, A.; Kahn, P.; Ao, E.; Campbell, J. K.; Otto, S.
10.1101/2025.02.12.637395 — evolutionary biology — Posted on 2025-02-14
2726 Land-use history causes differences in park nighttime cooling capacity and forest structure
Richmond, I. C.; Paulauskas, M. A.; Padvaiskas, E.; Sinisterra, L. C. G.; Hutt-Taylor, K.; Robitaille, A. L.; Ziter, C. D.
10.1101/2025.02.13.637130 — ecology — Posted on 2025-02-14
2728 Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid
Fita-Torro, J.; Garrido-Huarte, J. L.; Lopez-Gil, L.; Michel, A. H.; Kornmann, B.; Pascual-Ahuir, A.; Proft, M.
10.1101/2023.11.06.565743 — molecular biology — Posted on 2025-02-14
2729 Re-programming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation
Rios, I.; Herrero, C.; Torres Torresano, M.; Lopez-Navarro, B.; Schiaffino, M. T.; Diaz Crespo, F.; Nieto-Valle, A.; Samaniego, R.; Sierra-Palomares, Y.; Oliver, E.; Revuelta, F.; Garcia-Lujan, R.; Sanchez-Mateos, P.; Delgado, R.; Puig-Kroger, A.; Corbi, A. L.
10.1101/2024.08.20.608749 — immunology — Posted on 2025-02-14
2731 Control of tongue movements by the Purkinje cells of the cerebellum
Hage, P.; Fakharian, M. A.; Shoup, A. M.; Pi, J. S.; Sedaghat-Nejad, E.; Orozco, S. P.; Jang, I. K.; Looi, V.; Elseweifi, H.; Mohammadrezaei, N.; Vasserman, A.; Arginteanu, T.; Shadmehr, R.
10.1101/2024.07.25.604757 — neuroscience — Posted on 2025-02-14
2733 Locityper: targeted genotyping of complex polymorphic genes
Prodanov, T.; Plender, E. G.; Seebohm, G.; Meuth, S. G.; Eichler, E. E.; Marschall, T.
10.1101/2024.05.03.592358 — bioinformatics — Posted on 2025-02-14
2737 Long-term evaluation of the association between dominance, bib size, sex and age
Silva, N. J.; Silva, L. R.; D'Amelio, P. B.; Ferreira, A. C.; Lucas, A.; Covas, R.; Doutrelant, C.
10.1101/2025.02.13.638048 — animal behavior and cognition — Posted on 2025-02-14
2738 A century of theories of balancing selection
Ruzicka, F.; Zwoinska, M. K.; Goedert, D.; Kokko, H.; Richter, X.-Y. L.; Moodie, I.; Nilen, S.; Olito, C.; Svensson, E. I.; Czuppon, P.; Connallon, T.
10.1101/2025.02.12.637871 — evolutionary biology — Posted on 2025-02-14
2743 TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila
Hu, Y.; Rodiger, J.; Liu, Y.; Gao, C.; Liu, Y.; Qadiri, M.; Veal, A.; Bulyk, M. L.; Perrimon, N.
10.1101/2025.02.13.638157 — bioinformatics — Posted on 2025-02-14
2744 Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly
Zillich, L.; Gasparotto, M.; Rossetti, A. C.; Fechtner, O.; Maillard, C.; Hoffrichter, A.; Zillich, E.; Jabali, A.; Marsoner, F.; Wilkens, R.; Schroeter, C. B.; Hentschel, A.; Witt, S. H.; Melzer, N.; Meuth, S. G.; Ruck, T.; Koch, P.; Roos, A.; Bahi-Buisson, N.; Francis, F.; Ladewig, J.
10.1101/2022.12.19.520907 — neuroscience — Posted on 2025-02-14
2748 The role of human intraparietal sulcus in evidence accumulation revealed by EEG and model-informed fMRI
Wongtrakun, J.; Zhou, S.-H.; O'Connell, R. G.; Chong, T. T.-J.; Bellgrove, M. A.; Coxon, J. P.
10.1101/2025.02.05.636628 — neuroscience — Posted on 2025-02-14
2749 Smoke exposure triggers rapid transcriptional changes and reveals glycosyltransferases linked to smoke taint in ripening grape berries
Paineau, M.; Liang, C.; Cochetel, N.; Sharma, S.; Figueroa-Balderas, R.; Thilmony, R.; Rumbaugh, A.; Cantu, D.
10.1101/2025.02.11.637658 — plant biology — Posted on 2025-02-14
2750 Bacterial pathogen deploys iminosugar galactosyrin to manipulate plant glycobiology
Sanguankiattichai, N.; Chandrasekar, B.; Sheng, Y.; Hardenbrook, N.; Tabak, W. W. A.; Krahn, D.; Drapal, M.; Buscaill, P.; Yamamoto, S.; Kato, A.; Nash, R.; Fleet, G.; Fraser, P.; Kaiser, M.; Zhang, P.; Preston, G. M.; van der Hoorn, R. A. L.
10.1101/2025.02.13.638044 — plant biology — Posted on 2025-02-14
2751 Long-range electrostatic forces govern how proteins fold on the ribosome
Streit, J.; Chan, S. H. S.; Burridge, C.; Wallace, J.; Waudby, C. A.; Cabrita, L. D.; Christodoulou, J.
10.1101/2025.02.10.637539 — biophysics — Posted on 2025-02-14
2752 A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 channels
Li, S.; Wijerathne, T. D.; Bhatt, A.; Jiang, W.; Lacroix, J.; Han, W.; Luo, Y. L.
10.1101/2025.02.10.637531 — biophysics — Posted on 2025-02-14
2754 Probing the Role of Membrane in Neutralizing Activity of Antibodies Against Influenza Virus
Ozgulbas, D. G.; Tan, T. J. C.; Wen, P.-C.; Teo, Q. W.; Lv, H.; Ghaemi, Z.; Frank, M.; Wu, N. C.; Tajkhorshid, E.
10.1101/2025.02.11.637756 — biophysics — Posted on 2025-02-14
2761 Discovering new amyloid-like peptides using all-atom simulations and artificial intelligence.
Kuang, X.; Jalali, S.; Rahman, T.; Michalowski, J.; Sheng-Wong, C.; Wong-Ekkabut, J.; Su, Z.; Dias, C. L.
10.1101/2025.02.12.637911 — biophysics — Posted on 2025-02-14
2770 Onlinemeta: A Web Server for Meta-Analysis Based on Shiny Framework
Dai, W.; Yi, Y.; Lin, A.; Zhou, C.; Zhang, J.; Wang, S.; Sun, M.; Luo, P.
10.1101/2022.04.13.488126 — bioinformatics — Posted on 2025-02-14
2771 Locityper: targeted genotyping of complex polymorphic genes
Prodanov, T.; Plender, E. G.; Seebohm, G.; Meuth, S. G.; Eichler, E. E.; Marschall, T.
10.1101/2024.05.03.592358 — bioinformatics — Posted on 2025-02-14
2775 Informational Complexity as a Neural Marker of Cognitive Reserve
Stolp, L.; Mandke, K.; Mediano, P. A. M.; Gellersen, H. M.; Swartz, A.; Rudzka, K.; Simons, J.; Bekinschtein, T.; Bor, D.
10.1101/2025.02.13.638084 — neuroscience — Posted on 2025-02-14
2778 Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration
Lucas, T. A.; Novikova, G.; Rao, S.; Wang, Y. A.; Laufer, B. I.; Pandey, S.; Webb, M. G.; Jorstad, N.; Friedman, B. A.; Hanson, J. E.; Kaminker, J. S.
10.1101/2025.02.12.637903 — neuroscience — Posted on 2025-02-14
2779 A paradigm to study the learning of muscle activity patterns outside of the natural repertoire
Ghavampour, A.; Emanuele, M.; Sayyid, S. R.; Orban de Xivry, J.-J.; Michaels, J. A.; Pruszynski, J. A.; Diedrichsen, J.
10.1101/2025.02.13.638098 — neuroscience — Posted on 2025-02-14
2781 Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI
Autio, J. A.; Kimura, I.; Ose, T.; Matsumoto, Y.; Ohno, M.; Urushibata, Y.; Ikeda, T.; Glasser, M. F.; Van Essen, D. C.; Hayashi, T.
10.1101/2024.05.16.594068 — neuroscience — Posted on 2025-02-14
2782 Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue
Mesentier-Louro, L. A.; Goldman, C.; Ndayisaba, A.; Buonfiglioli, A.; Rooklin, R. B.; Schuldt, B. R.; Uchitelev, A.; Khurana, V.; Blanchard, J. W.
10.1101/2025.02.09.637107 — neuroscience — Posted on 2025-02-14
2789 Modeling cerebral development in vitro with L-MYC-immortalized human neural stem cell-derived organoids
Velazquez Ojeda, A.; Awabdeh, D.; Brewster, B.; Rockne, R.; O'Meally, D.; Yin, H. H.; Carlesso, N.; Brown, C. E.; Gutova, M.; Barish, M. E.
10.1101/2025.02.12.637976 — neuroscience — Posted on 2025-02-13
2792 Targeting lysosomal damage is a new therapeutic perspective for Duchenne Muscular Dystrophy
Jaber, A.; Palmieri, L.; Bakour, R.; Lachiver, E.; Vu Hong, A.; Bourg, N.; Poupiot, J.; Albini, S.; Stockholm, D.; Van Wittenberghe, L.; Miranda, A.; Daniele, N.; Barthelemy, I.; Blot, S.; Evangelista, T.; Bui, T. M.; Richard, I.; Israeli, D.
10.1101/2025.02.11.637610 — physiology — Posted on 2025-02-13
2793 Comparative population pangenomes reveal unexpected complexity and fitness effects of structural variants
Edwards, S. V.; Fang, B.; Khost, D.; Kolyfetis, G. E.; Cheek, R. G.; Deraad, D.; Chen, N.; Fitzpatrick, J. W.; McCormack, J. E.; Funk, W. C.; Ghalambor, C. K.; Garrison, E.; Guarracino, A.; Li, H.; Sackton, T. B.
10.1101/2025.02.11.637762 — evolutionary biology — Posted on 2025-02-13
2795 Lysogen formation governs colonies while lytic infection is more prevalent in single cells of the bloom-forming cyanobacterium, Microcystis
Huang, X.; Chase, E. E.; Zepernick, B. N.; Martin, R. M.; Krausfeldt, L. E.; Pound, H. L.; Wu, H.; Zheng, Z.; Wilhelm, S. W.
10.1101/2025.02.12.637950 — microbiology — Posted on 2025-02-13
2800 Candida auris skin colonization is mediated by Als4112 and interactions with host extracellular matrix proteins
Zhao, G.; Lyu, J.; Veniaminova, N. A.; Zarnowski, R.; Mattos, E.; Johnson, C. J.; Quintanilla, D.; Hautau, H.; Dasgupta, K.; Hold, L. A.; Xu, B.; Anku, J. A. E.; Steltzer, S. S.; Santana, D. J.; Ibrahim, A.; Andes, D.; Nett, J. E.; Singh, S.; Abraham, A. C.; Killian, M. L.; Kahlenberg, J. M.; Wong, S. Y.; O'Meara, T. R.
10.1101/2025.02.13.637978 — microbiology — Posted on 2025-02-13
2803 Metabolic Response of a Chemolithoautotrophic Archaeon to Carbon Limitation
Hodgskiss, L. H.; Kerou, M.; Luo, Z.-H.; Bayer, B.; Maier, A.; Weckwerth, W.; Naegele, T.; Schleper, C.
10.1101/2025.02.13.638070 — microbiology — Posted on 2025-02-13
2804 RNA virus ecogenomics along a subarctic permafrost thaw gradient
Pratama, A. A.; Dominguez-Huerta, G.; Wainaina, J. M.; Bolduc, B.; Tian, F.; Ellenbogen, J.; Guo, J.; EMERGE Field Team, ; EMERGE Coordinators, ; Kuhn, J. H.; Wrighton, K. C.; Zayed, A. A.; Sullivan, M. B.
10.1101/2025.02.13.637936 — microbiology — Posted on 2025-02-13
2805 Associations between gut microbiota and personality traits: insights from a captive common marmoset (Callithrix jacchus) colony
Ye, H.; Slipogor, V.; Hanson, B. T.; Seneca, J.; Hausmann, B.; Herbold, C. W.; Pjevac, P.; Bugnyar, T.; Loy, A.
10.1101/2025.02.12.637913 — microbiology — Posted on 2025-02-13
2808 Probing the zooarchaeological record across time and space for ancient pathogens
Runge, A. K. W.; Light-Maka, I.; Massy, K.; Keller, M.; Trixl, S.; Kabral, H.; Kirkpatrick, C. L.; Bos, K.; Eger, J.; Ernee, M.; Kysely, R.; Hochmuth, M.; Poradowski, D.; Chroszcz, A.; Benecke, N.; Danecek, D.; Klementova, J.; Nagler, A.; Kalmykov, A. A.; Kantorovich, A. R.; Maslov, V. E.; Belinskiy, A. B.; Scheib, C. L.; Toderas, M.; Hansen, S.; Stockhammer, P. W.; Kaniuth, K.; Uhl, R.; Reinhold, S.; Gillis, R. E.; Nelson, E. A.; Pawlowska, K.; Key, F. M.
10.1101/2025.02.12.637901 — microbiology — Posted on 2025-02-13
2811 The effect of chronic stress and chronic alcohol intake on behavior, brain structure, and functional connectivity in a rat model
Toledo, J. R.; Angeles Valdez, D.; Carranza-Aguilar, C. J.; Lopez-Castro, A.; Trujillo-Villarreal, L. A.; Medina-Sanchez, D.; Serrano-Ramirez, M. S.; Elizarraras-Herrera, A. D.; Alcauter, S.; Delint-Ramirez, I.; Gutierrez, R.; Devenyi, G. A.; Chakravarty, M.; Garza-Villarreal, E. A.
10.1101/2025.02.13.638122 — neuroscience — Posted on 2025-02-13
2815 From Archaea to the atmosphere: remotely sensing Arctic methane
Varner, R. K.; Cronin, D. R.; Crill, P.; Palace, M.; McCalley, C. K.; Deng, J.; Herrick, C.; Kuhn, M.; Hodgkins, S. B.; McArthur, K.; Singer, J. D.; Bolduc, B.; Li, Y.-F.; The Archaea to Atmosphere (A2A) Project Team, ; EMERGE Institute Coordinators, ; Li, C.; Tyson, G.; Frolking, S.; Chanton, J. P.; Persson, A.; Saleska, S. R.; Rich, V. I.
10.1101/2025.02.13.638097 — microbiology — Posted on 2025-02-13
2816 Comprehensive Metagenomic Profiling of Diverse Microbiomes
Kakuk, B.; Dormo, A.; Taifi, A.; Jaray, T.; Kurucsai, G.; Gulyas, G.; Prazsak, I.; Boldogkoi, Z.; Tombacz, D.
10.1101/2025.02.13.638056 — microbiology — Posted on 2025-02-13
2818 Mobile genetic elements that shape microbial diversity and functions inthawing permafrost soils
Guo, J.; Aroney, S.; Dominguez-Huerta, G.; Smith, D.; Vik, D.; Ansah, C. O.; Pratama, A. A.; Solonenko, S.; Tian, F.; Howard-Varona, C.; Zhong, Z.; Fofana, A.; Smith, G.; Hodgkins, S. B.; Cronin, D.; EMERGE Field Teams 2010-2019, ; EMERGE Coordinators, ; Woodcroft, B. J.; Tyson, G. W.; Rich, V. I.; Sullivan, M. B.; Roux, S.; Bagby, S. C.
10.1101/2025.02.12.637893 — microbiology — Posted on 2025-02-13
2820 Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis
Gruenebast, J.; Singhal, R.; Bromley, R.; Kanatani, S.; Watson, K.; Dumetz, F.; Pascini, T.; Tripathi, A.; Dunning Hotopp, J. C.; Sinnis, P.; Llinas, M.; Serre, D.
10.1101/2025.02.12.637867 — microbiology — Posted on 2025-02-13
2822 A connection between Vibrio cholerae motility and inter-animal transmission
Campbell, I. W.; Dehinwal, R.; Morano, A. A.; Dailey, K. G.; Zingl, F. G.; Waldor, M. K.
10.1101/2025.02.12.637895 — microbiology — Posted on 2025-02-13
2825 Staphylococcal Internalization into Osteoblasts: A Partially Conserved Mechanism Across the Genus
Crepin, D. M.; Bonhomme, M.; Faure, A.; Sinel, C.; Bergot, M.; Dyon-Tafani, V.; Maali, Y.; Bouvard, D.; Diot, A.; Laurent, F.; Josse, J.
10.1101/2025.02.13.638029 — microbiology — Posted on 2025-02-13
2826 Linking Transcriptional and Cellular Responses of Human and Murine Pneumococcal Pneumonia
Gorki, A.-D.; Lakovits, K.; Hladik, A.; Mesteri, I.; Gawish, R.; Martins, R.; Drobits, B.; Menche, J.; Knapp, S.; Widder, S.
10.1101/2025.02.13.638069 — microbiology — Posted on 2025-02-13
2827 Spike-specific IgG4 generated post BNT162b2 mRNA vaccination is inhibitory when directly competing with functional IgG subclasses
Tam, J. C. H.; Sibayan, A. C.; Seow, J.; Graham, C.; Kurshan, A.; Merrick, B.; Stanton, R. J.; Doores, K. J.
10.1101/2025.02.12.637095 — immunology — Posted on 2025-02-13
2828 Annexin A1 as a key modulator of lung inflammation during coronavirus infections
Resende, F.; Queiroz-Junior, C. M.; Ascencao, F. R.; Chaves, I. d. M.; Lacerda, L. d. S. B.; Rocha, F.; Teixeira, D.; Galvao, I.; Costa, V.; Fonseca, T.; Gualberto, A.; Santos, A. L. d. C.; Martins, J.; Lima, E. B. d. S.; Monteiro, A. H. A.; Zaidan, I.; Grossi, L.; Costa, P. A. C.; Beltrami, V. A.; de Sousa, L. P.; Guimaraes, P. P. G.; Campolina-Silva, G.; Teixeira, M. M.; Pinho, V.; Costa, V. V.
10.1101/2025.02.12.637941 — immunology — Posted on 2025-02-13
2830 HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors
Alfajaro, M. M.; Keeler, E. L.; Li, N.; Cantanzaro, N. J.; Teng, I.-T.; Zhao, Z.; Grunst, M. W.; Yount, B.; Schaefer, A.; Wang, D.; Kim, A.; Synowiec, A.; Pena-Hernandez, M. A.; Arinola, R.; Kaur, R.; Menasche, B. L.; Wei, J.; Russell, G. A.; Huck, J.; Song, J.; Ring, A.; Iwasaki, A.; Jangra, R. K.; Lee, S.; Martinez, D. R.; Mothes, W.; Uchil, P. D.; Doench, J. G.; Spaulding, A.; Baric, R. S.; Serebryannyy, L.; Tsybovsky, Y.; Zhou, T.; Doueck, D.; Wilen, C. B.
10.1101/2025.02.12.637862 — microbiology — Posted on 2025-02-13
2832 BioMapAI: Artificial Intelligence Multi-Omics Framework Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Xiong, R.; Aiken, E.; Caldwell, R.; Vernon, S. D.; Kozhaya, L.; Gunter, C.; Bateman, L.; Unutmaz, D.; Oh, J.
10.1101/2024.06.24.600378 — bioinformatics — Posted on 2025-02-13
2833 Master transcription factor binding sites constitute the core of early replication control elements
Turner, J. L.; Hinojosa-Gonzalez, L.; Sasaki, T.; Uchino, S.; Vouzas, A.; Soto, M. S.; Chakraborty, A.; Alexander, K. E.; Fitch, C. A.; Brown, A. N.; Ay, F.; Gilbert, D. M.
10.1101/2023.10.22.563497 — molecular biology — Posted on 2025-02-13
2834 An opioid efficacy switch for reversible optical control of peripheral analgesia
Posa, L.; Romano, G.; Ji, X.; Khan, S.; Paz, B.; Han, G. W.; Nazarova, A. L.; Zaidi, S. A.; Ranjbar, M.; Pleil, K. E.; Katritch, V.; Gati, C.; Trauner, D.; Levitz, J.
10.1101/2024.12.16.628735 — pharmacology and toxicology — Posted on 2025-02-13
2835 Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system
Burnicka-Turek, O.; Trampel, K. A.; Laforest, B.; Broman, M. T.; Yang, X.; Khan, Z.; Rytkin, E.; Li, B.; Schaffer, E.; Gadek, M.; Shen, K. M.; Efimov, I. R.; Moskowitz, I. P.
10.1101/2024.08.29.610377 — developmental biology — Posted on 2025-02-13
2836 Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2
Raig, N. D.; Surridge, K. J.; Sanz-Murillo, M.; Dederer, V.; Kramer, A.; Schwalm, M. P.; Elson, L.; Chatterjee, D.; Mathea, S.; Hanke, T.; Leschziner, A. E.; Reck-Peterson, S. L.; Knapp, S.
10.1101/2024.09.17.613365 — cell biology — Posted on 2025-02-13
2837 Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues
Stein, J.; Ericsson, M.; Nofal, M.; Magni, L.; Aufmkolk, S.; McMillan, R. B.; Breimann, L.; Herlihy, C. P.; Lee, S. D.; Willemin, A.; Wohlmann, J.; Arguedas-Jimenez, L.; Yin, P.; Pombo, A.; Church, G. M.; Wu, C.-t.
10.1101/2024.02.05.576943 — cell biology — Posted on 2025-02-13
2838 Social, cognitive and sensory dimensions of cortical network overconnectivity in young children with autism spectrum disorder
Rodriguez-Herreros, B.; Mheich, A.; Almeida Osorio, J. M.; Richetin, S.; Junod, V.; Arnold, L.; Aeschbach, V.; Adamou, L. N.; Mendes, L.; Gschwend, K.; Romascano, D.; Yu, P.; HASSAN, M.; Chabane, N.
10.1101/2025.02.12.637813 — neuroscience — Posted on 2025-02-13
2842 Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex
Khan, A. U.; Hoy, C. W.; Anderson, K. L.; Piai, V.; King-Stephens, D.; Laxer, K. D.; Weber, P.; Lin, J. J.; Knight, R. T.; Bentley, J. N.
10.1101/2025.02.12.637987 — neuroscience — Posted on 2025-02-13
2843 Overexpressing NRT2.7 induces nitrate export from the vacuole and increases growth of Arabidopsis
Armengaud, P.; De Angeli, A.; Berquin, P.; Brehaut, V.; Durand, M.; Daniel-Vedele, F.; Krapp, A.; Filleur, S.
10.1101/2024.02.26.582130 — plant biology — Posted on 2025-02-13
2844 Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.
Diao, S.; Zou, J. Y.; Wang, S.; Ghaddar, N.; Chan, J. E.; Kim, H.; Poulain, N.; Koumenis, C.; Hatzoglou, M.; Walter, P.; Sonenberg, N.; Le Quesne, J.; Tammela, T.; Koromilas, A. E.
10.1101/2025.02.10.637516 — cancer biology — Posted on 2025-02-13
2846 All-Atom Protein Generation with Latent Diffusion
Lu, A. X.; Yan, W.; Robinson, S. A.; Kelow, S.; Yang, K. K.; Gligorijevic, V.; Cho, K.; Bonneau, R.; Abbeel, P.; Frey, N. C.
10.1101/2024.12.02.626353 — bioinformatics — Posted on 2025-02-13
2850 Mating strategy explains sex-biased infections in an emerging fungal disease
Kailing, M. J.; Hoyt, J. R.; White, J. P.; Redell, J. A.; Kaarakka, H. M.; Langwig, K. E.
10.1101/2024.09.02.609945 — ecology — Posted on 2025-02-13
2851 A Novel Mouse Model of Parkinson's Disease for Investigating Progressive Pathology and Neuroprotection
Subramanya, S. K.; Shekhar, S.; Kumar, D. B.; Senthil, S.; ALLIMUTHU, D.; Luk, K.; Thakur, P.
10.1101/2025.02.13.638053 — neuroscience — Posted on 2025-02-13
2852 Common Neural Choice Signals reflect Accumulated Evidence, not Confidence
Desender, K.; Smet, A.; Erdil, D.; Gunay, E. M.; Le Denmat, P.; Van Marcke, H.
10.1101/2025.02.13.638046 — neuroscience — Posted on 2025-02-13
2857 Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors
Zhu, M.; Peng, J.; Wang, M.; Lin, S.; Zhou, Y.; Dai, X.; Zhao, H.; Zhang, H.; Yu, Y.-Q.; Shen, L.; Li, X.-M.; Chen, J.
10.1101/2025.02.10.637400 — neuroscience — Posted on 2025-02-13
2859 A next-generation neural mass model with neuromodulation
Depannemaecker, D.; Duprat, C.; Casagrande, G.; Saggio, M. L.; Angiolelli, M.; Athanasiadis, A. P.; Sales Carbonell, C.; Wang, H.; Petkoski, S.; Sorrentino, P.; McIntosh, R.; Sheheitli, H.; Jirsa, V.
10.1101/2024.06.23.600260 — neuroscience — Posted on 2025-02-13
2862 Dissociating the incubation of appetitive and consummatory behavior in a model of oral cocaine self-administration
Namba, M. D.; Goldberg, S. L.; Side, C. M.; Yadlapalli, A.; Curran-Alfaro, C. M.; Kress, D.; Fogarty, M. F.; Mohr, A. L.; Barker, J. M.
10.1101/2025.02.12.637922 — neuroscience — Posted on 2025-02-13
2863 Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex
Yu, P.; Yang, Y.; Gozel, O.; Oldenburg, I.; Dipoppa, M.; Rossi, F.; Miller, K.; Adesnik, H.; Ji, N.; Doiron, B.
10.1101/2025.02.11.637768 — neuroscience — Posted on 2025-02-13
2864 Elusive scents: neurocomputational mechanisms of verbal omissions in free odor naming
Chrysanthidis, N.; Raj, R.; Horberg, T.; Lindroos, R.; Lansner, A.; Laukka, E. J.; Olofsson, J.; Herman, P. A.
10.1101/2025.02.13.637907 — neuroscience — Posted on 2025-02-13
2865 Exposure to bullying engages social distress circuits in the adolescent and adult brain
Paranko, B.; Garandeau, C.; Seppälä, K.; Putkinen, V.; Santavirta, S.; Hirvonen, J.; Salmivalli, C.; Nummenmaa, L.
10.1101/2025.02.12.637599 — neuroscience — Posted on 2025-02-13
2867 Non-canonical internalization mechanisms of mGlu receptors
Pin, J.-P.; Cimadevila, M.; Liu, J.; Maurel, D.; Brabet, I.; Hoscar, M.; Drube, J.; Hoffmann, C.; Inoue, A.; RONDARD, p.; Lafon, P.-A.; Prezeau, L.
10.1101/2025.02.13.638043 — neuroscience — Posted on 2025-02-13
2868 Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth.
Vieira, R. F.; Sanchez, S. R.; Arumugam, M.; Mower, P. D.; Curtin, M. C.; Gallop, M. R.; Wright, J.; Bowles, A.; Ducker, G. S.; Hilgendorf, K. I.; Chaix, A.
10.1101/2025.02.10.637542 — cancer biology — Posted on 2025-02-13
2870 Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors
Ni, X.; Richardson, R. B.; de Godoy, A. S.; Ferla, M. P.; Kikawa, C.; Scheen, J.; Hannon, W. W.; Capkin, E.; Lahav, N.; Balcomb, B. H.; Marples, P. G.; Fairhead, M.; Wang, S.; Williams, E.; Tomlinson, C. W. E.; Aschenbrenner, J. C.; Lithgo, R.; Winokan, M.; Girould, C.; Chandran, A. V.; Walsh, M. A.; Thompson, W.; Bloom, J. D.; Barr, H.; Kirkegaard, K.; Koekemoer, L.; Fearon, D.; Evans, M. J.; von Delft, F.
10.1101/2024.04.29.591502 — biochemistry — Posted on 2025-02-13
2871 A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome
de los Reyes-Ramirez, L.; Bergada-Martinez, A.; Martinez-Torres, S.; Martinez-Gallego, I.; Losada-Ruiz, P.; Arboleya, S.; Gueimonde, M.; Maldonado, R.; Rodriguez-Moreno, A.; Ozaita, A.
10.1101/2025.01.24.634730 — animal behavior and cognition — Posted on 2025-02-13
2872 Comparison and evaluation of methods to infer gene regulatory networks from multimodal single-cell data
Badia-i-Mompel, P.; Casals-Franch, R.; Wessels, L.; Müller-Dott, S.; Trimbour, R.; Yang, Y.; Ramirez Flores, R. O.; Saez-Rodriguez, J.
10.1101/2024.12.20.629764 — genomics — Posted on 2025-02-13
2873 An archaeal CBASS system eliminates viruses without killing the host cells
Choudhary, D. K.; Singla, H.; Vassover, D.; Golan, N.; Reshef, L.; Shukrun, H.; Gophna, U.
10.1101/2024.09.12.612678 — microbiology — Posted on 2025-02-13
2875 Spike Train Scalograms (STS): a Deep Learning Classification Pipeline for Neuronal Cell Types
Amprimo, G.; Martini, L.; Bilir, B.; Bardini, R.; Savino, A.; Olmo, G.; Di Carlo, S.
10.1101/2025.02.10.637424 — bioinformatics — Posted on 2025-02-13
2877 Deep learning-based prediction of tissue-specific splice sites in the human neural retina
Riepe, T. V.; de Bruijn, S. E.; Roosing, S.; Cremers, F. P. M.; 't Hoen, P. A. C.
10.1101/2025.02.10.637427 — bioinformatics — Posted on 2025-02-13
2879 Craft: A Machine Learning Approach to Dengue Subtyping
van Zyl, D. J.; Dunaiski, M.; Tegally, H.; Baxter, C.; de Oliveira, T.; Xavier, J. S.; The INFORM Africa research study group,
10.1101/2025.02.10.637410 — genomics — Posted on 2025-02-13
2880 Spatial dynamics of the tumor microenvironment in emerging resistance to targeted therapy in EGFR-mutated NSCLC
Nakamura, S.; Shibahara, D.; Tanaka, K.; Kishikawa, Y.; Hashisako, M.; Nakatomi, K.; Nakagaki, N.; Kohno, M.; Azuma, K.; Ibusuki, R.; Otsubo, K.; Yoneshima, Y.; Iwama, E.; Oda, Y.; Okamoto, I.
10.1101/2025.02.10.637543 — cancer biology — Posted on 2025-02-13
2881 Inhibitory control in reptiles
Santaca', M.; Wilkinson, A.; Stancher, G.; Sovrano, V. A.; Bisazza, A.
10.1101/2025.02.12.637795 — animal behavior and cognition — Posted on 2025-02-13
2883 State or personality trait: Determinants of boldness and shoal size preference in adult zebrafish
Singh, A.; Sharma, P.; Jain, M.; Mahajan, P.; Bajaj, J.; Gupta, V.; Dingemanse, N.; Rajaraman, B. K.
10.1101/2025.02.12.637681 — animal behavior and cognition — Posted on 2025-02-13
2887 Temperature-dependence of Early Development of Zebrafish and the Consequences for Laboratory Use and Animal Welfare
Miller, A.; Schroeder, K. L.; Braun, K. E.; Steindorf, C.; Ottermanns, R.; Ross-Nickoll, M.; Hollert, H.; Backhaus, T.
10.1101/2025.02.13.638062 — developmental biology — Posted on 2025-02-13
2888 Cortical control of innate behavior from subcortical demonstration
Keller, J. A.; Kwak, I. S.; Stark, A. K.; Pachitariu, M.; Branson, K.; Dudman, J. T.
10.1101/2025.02.12.637930 — neuroscience — Posted on 2025-02-13
2889 Perception and neural representation of intermittent odor stimuli in mice
Boero, L. E.; Wu, H.; Zak, J. D.; Masset, P.; Pashakhanloo, F.; Jayakumar, S.; Tolooshams, B.; Ba, D.; Murthy, V. N.
10.1101/2025.02.12.637969 — neuroscience — Posted on 2025-02-13
2890 Neuromodulation of the endbulb of Held synapse in the cochlear nucleus
Groshkova, M. B.; Alvanos, T.; Qi, Y.; Wang, F.; Wichmann, C.; Hua, Y.; Moser, T.
10.1101/2025.02.12.637882 — neuroscience — Posted on 2025-02-13
2896 Oxalotrophic bacteria in desert and drylands: Enzymatic pathways and Carbon sequestration
Nagarajan, A. P.; Parween, S.; Froehlich, K.; Schmidt, T.; Shekhawat, K. S.; Prabhu, D. R.; Saad, M. M.; Hirt, H.
10.1101/2025.02.10.637404 — bioinformatics — Posted on 2025-02-13
2901 ABCF Protein-Mediated Resistance Shapes Bacterial Responses to antibiotics Based on THEIR Type and Concentration
Koberska, M.; Vesela, L.; Novotna, M.; Mahor, D.; Mazumdar, A.; Pindakova, N.; Petravicius, P. O.; Pokorna, J.; Kamenik, Z.; Balikova Novotna, G.
10.1101/2025.02.10.637581 — microbiology — Posted on 2025-02-13
2902 Global Transcriptomics and Targeted Metabolite Analysis Reveal the Involvement of the AcrAB Efflux Pump in Physiological Functions by Exporting Signaling Molecules in Photorhabdus laumondii
Hadchity, L.; Lanois-Nouri, A.; Chouchou, A.; Roche, D.; Houard, J.; Claveyroles, N.; Dauve, A.; Imbert, J.; Gualtieri, M.; GIVAUDAN, A.; Carre-Mlouka, A.; Abi Khattar, Z.
10.1101/2025.02.10.637478 — microbiology — Posted on 2025-02-13
2903 Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases
Sadeghpour, N.; Lim, S. A.; Wuestefeld, A.; Denning, A. E.; Ittyerah, R.; Trotman, W.; Chung, E.; Sadaghiani, S.; Prabhakaran, K.; Bedard, M. L.; Ohm, D. T.; Artacho-Perula, E.; Iniguez de Onzono Martin, M. M.; Munoz, M.; Molina Romero, F. J.; Delgado Gonzalez, J. C.; Arroyo Jimenez, M. d. M.; Marcos Rabal, M. d. P.; Insausti Serrano, A. M.; Vilaseca Gonzalez, N.; Cebada Sanchez, S.; de la Rosa, C. T.; Insausti, R.; McMillan, C.; Lee, E. B.; Detre, J. A.; Das, S. R.; Xie, L.; Tisdall, D.; Irwin, D. J.; Wolk, D. A.; Yushkevich, P.; Wisse, L.
10.1101/2025.02.11.637506 — neuroscience — Posted on 2025-02-13
2904 Fast-timescale hippocampal processes bridge between slowly unfurling neocortical states during memory search
Michelmann, S.; Dugan, P.; Doyle, W.; Friedman, D.; Melloni, L.; Strauss, C.; Devore, S.; Flinker, A.; Devinsky, O.; Hasson, U.; Norman, K. A.
10.1101/2025.02.11.637471 — neuroscience — Posted on 2025-02-13
2907 Membrane partition and structural reorganization induced by anti-psychotics with distinct clinical profiles
Gorse, A.; Yordanova, V. V.; Bodosa, J.; Mathelie-Guinlet, M.; Walrant, A.; Taib-Maamar, N.; Grelard, A.; Francois-Martin, C.; Baccouch, R.; Rascol, E.; Salgado, G.; Moreno, M. J.; Bastos, M.; Klauda, J. B.; Staneva, G.; Nuss, P.; Dantas Alves, I. M.
10.1101/2025.02.10.637357 — biophysics — Posted on 2025-02-13
2911 Subcortical correlates of consciousness with human single neuron recordings
Pereira, M.; Faivre, N.; Bernasconi, F.; Brandmeir, N.; Suffridge, J.; Tran, K.; Wang, S.; Finomore, V.; Konrad, P.; Rezai, A.; Blanke, O.
10.1101/2023.01.27.525684 — neuroscience — Posted on 2025-02-13
2914 Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits
Bian, C.; Demirer, G. S.; Oz, M. T.; Cai, Y.; Witham, S.; Mason, G. A.; Di, Z.; Deligne, F.; Zhang, P.; Shen, R.; Gaudinier, A.; Brady, S.; Patron, N.
10.1101/2023.07.17.549299 — plant biology — Posted on 2025-02-13
2918 Encapsulation-enhanced genetic switches in lactobacilli
Blanch-Asensio, M.; Tadimarri, V. S.; Martinez, R. P.; Dahiya, G. S.; Lale, R.; Sankaran, S.
10.1101/2025.01.10.632477 — bioengineering — Posted on 2025-02-13
2920 The nephronophthisis protein GLIS2/NPHP7 is required for the DNA damage response in kidney tubular epithelial cells
Ebert, L. K.; Schloesser, L.; Frech, L.; Jain, M.; Dafinger, C.; Liebau, M. C.; Benzing, T.; Schermer, B.; Slaats, G. G.
10.1101/2024.11.02.621644 — cell biology — Posted on 2025-02-13
2921 RNase III cleavage signals spread across splice junctions enforce sequential processing of co-hosted snoRNAs.
Migeot, V.; Mary, Y.; Fafard-Couture, E.; Lombard, P.; Bachand, F.; Scott, M. S.; Yague-Sanz, C.
10.1101/2025.01.08.631648 — molecular biology — Posted on 2025-02-13
2922 Mechanisms of gene regulation by SRCAP and H2A.Z
Tollenaere, A.; Ugur, E.; Dalla-Longa, S.; Deluz, C.; Assenheimer, D.; Gebhardt, J. C. M.; Leonhardt, H.; Suter, D. M.
10.1101/2024.06.07.597899 — molecular biology — Posted on 2025-02-13
2925 RIG-I Stimulation Enhances Effector Function and Proliferation of Primary Human CD8 T Cells
Mohamed, A. A.; Wallerath, C.; Hunkler, C.; Hartmann, G.; Stankovic, S.; Brooks, A.; Schlee, M.
10.1101/2025.01.27.635030 — immunology — Posted on 2025-02-13
2928 Precise calcium-to-spike inference using biophysical generative models
Broussard, G. J.; Diana, G.; Urra Quiroz, F. J.; Sermet, B. S.; Rebola, N.; Lynch, L. A.; DiGregorio, D. A.; Wang, S. S.- H.
10.1101/2024.12.31.630967 — neuroscience — Posted on 2025-02-13
2930 Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling
Patel, R.; Cheng, R.; Cardona, C. L.; Angeles, E.; Singh, G.; Miller, S.; Ashok, A.; Teich, A. F.; Piriz, A.; Maldonado, A.; Jimenez-Velazquez, I. Z.; Mayeux, R.; Lee, J. H.; Sproul, A. A.
10.1101/2024.06.23.600281 — neuroscience — Posted on 2025-02-13
2935 Open-source cell culture automation system with integrated cell counting for passaging microplate cultures
Courville, G.; Vaid, S.; Toruno, A.; Lebel, P.; Cabrera, J.; Raghavan, P.; Jacobsen, A.; Bell, G. R.; Leonetti, M. D.; Gomez-Sjöberg, R.
10.1101/2024.12.27.629034 — bioengineering — Posted on 2025-02-13
2936 Massively parallel assessment of gene regulatory activity at human cortical structure associated variants
Matoba, N.; McAfee, J. C.; Krupa, O.; Bell, J.; Le, B. D.; Valone, J. M.; Crawford, G. E.; Won, H.; Stein, J. L.
10.1101/2025.02.08.635393 — genetics — Posted on 2025-02-13
2938 Population genetics meets ecology: a guide to individual-based simulations in continuous landscapes
Chevy, E. T.; Min, J.; Caudill, V.; Champer, S. E.; Haller, B. C.; Rehmann, C. T.; Smith, C. C. R.; Tittes, S.; Messer, P. W.; Kern, A. D.; Ramachandran, S.; Ralph, P. L.
10.1101/2024.07.24.604988 — evolutionary biology — Posted on 2025-02-13
2941 Offshore Wind and Aerofauna: Avoidance Remains the Best Bet Amid Limited Mitigation Evidence
Gulka, J.; Knapp, S.; Soccorsi, A.; Avery-Gomm, S.; Knaga, P.; Williams, K. A.
10.1101/2024.08.20.608845 — ecology — Posted on 2025-02-13
2942 Bird population trend analyses for a monitoring scheme with a highly structured sampling design
Rieger, M. R.; Grueneberg, C.; Oberhaus, M.; Trautmann, S.; Parepa, M.; Anthes, N.
10.1101/2024.06.30.601382 — ecology — Posted on 2025-02-13
2944 Dynamic Proximal Interactomics and Chemical Genetic Screening Reveal CCR4-NOT Sequestration in Stress Granules as a Mechanism for Transcript Stabilization
Tsai, Y.-C.; Uechi, H.; Millar, S. R.; Kadijk, E.; Schreiber, K. J.; Minkovich, A.; Huang, J. Q.; Kasmaeifar, V.; Zhang, Z.; Barsacchi, R.; Möbius, C.; Janosch, A.; Savage, J. C.; Röst, H.; Hyman, A. A.; Youn, J.-Y.
10.1101/2025.02.04.636058 — cell biology — Posted on 2025-02-13
2945 Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains
Thiono, D. J.; Samaras, D. L.; Phan, T.; Zhu, D. R.; Shah, R. P.; Castillo, I. N.; Forsberg, L. J.; Premkumar, L.; Baric, R. S.; Tian, S.; Kuhlman, B.; de Silva, A. M.
10.1101/2024.07.18.604114 — microbiology — Posted on 2025-02-13
2946 Chemosynthesis enhances carbon fixation in an active microbialite ecosystem
Ricci, F.; Leung, P. M.; Hutchinson, T.; Nguyen-Dinh, T.; Hood, A. v. S.; Salazar, V. W.; Eate, V.; Wong, W. W.; Cook, P. L. M.; Greening, C.; McClelland, H.
10.1101/2024.12.18.629060 — microbiology — Posted on 2025-02-13
2947 IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2
Lee, C.; Khan, R.; Mantsounga, C. S.; Sharma, S.; Pierce, J.; Amelotte, E.; Butler, C. A.; Farinha, A.; Parry, C.; Caballero, O.; Morrison, J. A.; Uppuluri, S.; Whyte, J. J.; Kennedy, J. L.; Zhang, X.; Choudhary, G.; Olson, R. M.; Morrison, A. R.
10.1101/2024.12.24.630260 — immunology — Posted on 2025-02-13
2949 Hippocampal ERK2 dimerization is critical for memory reconsolidation and synaptic plasticity
Ojea Ramos, S.; Medina, C.; Krawczyk, M. d. C.; Millan, J.; Acutain, M. F.; Romano, A.; Baez, M. V.; Urbano, F.; Boccia, M. M.; Feld, M.
10.1101/2024.09.06.611755 — neuroscience — Posted on 2025-02-13
2950 Revealing motor behavior patterns and functional improvement trajectories following spinal cord injury using unsupervised machine learning
Eisdorfer, J. T.; Lin, S.; Thackray, J. K.; Theis, T.; Vivinetto, A.; Oputa, O.; Martinez, A. M.; Nacht, H. D.; Tschang, M.; Mahmood, M.; Tucker, A.; Ruven, C.; Pusuloori, S.; Zmoyro, L.; Kumar, S.; Abraira Lab Computational Group, ; Schachner, M.; Sahni, V.; Popovich, P.; Ferguson, A. R.; McTigue, D.; Tysseling, V. M.; Dulin, J.; Hollis, E.; Datta, S. R.; Abraira, V. E. G.
10.1101/2023.10.31.564826 — neuroscience — Posted on 2025-02-13
2952 Differential effects of dopamine and serotonin on reward and punishment processes in humans: A systematic review and meta-analysis
Mkrtchian, A.; Qiu, Z.; Abir, Y.; Erdmann, T.; Dercon, Q.; Sedlinska, T.; Browning, M.; Costello, H.; Huys, Q. J. M.
10.1101/2025.01.08.631868 — neuroscience — Posted on 2025-02-13
2956 Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context
Bali, S.; Singh, R.; Wydorski, P. M.; van Nuland, N.; Wosztyl, A.; Perez, V. A.; chen, d.; Chen, J.; Rizo, J.; Joachimiak, L. A.
10.1101/2023.12.13.571598 — biophysics — Posted on 2025-02-13
2958 CellSAM: A Foundation Model for Cell Segmentation
Israel, U.; Marks, M.; Dilip, R.; Li, Q.; Yu, C.; Laubscher, E.; Iqbal, A.; Pradhan, E.; Ates, A.; Abt, M.; Brown, C.; Pao, E.; Li, S.; Pearson-Goulart, A.; Perona, P.; Gkioxari, G.; Barnowski, R.; Yue, Y.; Van Valen, D. A.
10.1101/2023.11.17.567630 — bioinformatics — Posted on 2025-02-13
2959 MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids
Lange, T.; Naji, A.; van der Hoeven, R.; Liang, H.; Zhou, Y.; Hammond, G. R.; Hancock, J. F.; Cho, K.-J.
10.1101/2024.01.22.576612 — cell biology — Posted on 2025-02-13
2960 GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine
Yamamoto, T.; Ueji, K.; Mizuta, H.; Inui-Yamamoto, C.; Kumamoto, N.; Shibata, Y.; Ugawa, S.
10.1101/2024.08.30.610470 — neuroscience — Posted on 2025-02-13
2961 Bridging verbal coordination and neural dynamics
Mohamed, I. S.; Mercier, M. R.; Trebuchon, A.; Morillon, B.; Lancia, L.; Schon, D.
10.1101/2024.04.23.590817 — neuroscience — Posted on 2025-02-13
2962 The heartbeat-evoked potential in young and older adults during attention orienting
Aprile, F.; Simoes, M.; Henriques, J.; de Carvalho, P.; Castelo-Branco, M.; Sel, A.; Ribeiro, M. J.
10.1101/2024.01.31.578137 — neuroscience — Posted on 2025-02-13
2964 Daily ultrastructural remodeling of clock neurons
Ispizua, J. I.; Rodriguez-Caron, M.; Tassara, F. J.; Kim, K.-y.; Perkins, C. I.; Barzi, M.; Carpio-Romero, C.; Vasquez, M.; Hansen, C. N.; Gargiulo, J.; Rosato, E.; de la iglesia, H.; Ellisman, M.; Ceriani, M. F.
10.1101/2024.11.06.622332 — neuroscience — Posted on 2025-02-13
2967 The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations
Jana, U.; Rodriguez, O. L.; Lees, W.; Engelbrecht, E.; Vanwinkle, Z.; Peres, A.; Gibson, W.; Shields, K.; Schultze, S.; Dorgham, A. G.; Emery, M.; Deikus, G.; Sebra, R.; Eichler, E. E.; Yaari, G.; Smith, M. L.; Watson, C. T.
10.1101/2025.02.12.634878 — genomics — Posted on 2025-02-12
2979 Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis
Christian, L.; Yilmaz, H.; Ruwisch, J.; Giercke, L.; Seeliger, B.; Kamp, J.-C.; Bayraktar, S.; Ewen, R.; Graalmann, T.; Fuge, J.; Greer, M.; Ius, F.; Welte, T.; Hohlfeld, J. M.; Hoeper, M. M.; Gottlieb, J.; Kaminski, N.; Prasse, A.; Jonigk, D.; Li, Y.; Falk, C.; Neubert, L.; Schupp, J. C.
10.1101/2025.02.11.636632 — molecular biology — Posted on 2025-02-12
2984 Small molecules reveal differential shifts in stability and protein binding for G-quadruplex RNA
Martyr, J. G.; Zafferani, M.; Bailey, M. A.; Zorawski, M. D.; Montalvan, N. I.; Muralidharan, D.; Fitzgerald, M. C.; Hargrove, A. E.
10.1101/2025.02.10.637408 — biochemistry — Posted on 2025-02-12
2987 Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships
Shevade, K.; Yang, Y. A.; Feng, K.; Mader, K.; Sevim, V.; Parsons, J.; Arora, G.; Elfawy, H.; Mace, R.; Federman, S.; Esanov, R.; Shafer, S.; Chow, E. D.; Przybyla, L.
10.1101/2025.02.11.637716 — genomics — Posted on 2025-02-12
2988 Population-scale cellular GUIDE-seq-2 and biochemical CHANGE-seq-R profiles reveal human genetic variation frequently affects Cas9 off-target activity
Tsai, S.; Lazzarotto, C.; Li, Y.; Flory, A. R.; Chyr, J.; Yang, M.; Katta, V.; Urbina, E.; Lee, G.; Wood, R.; Matsubara, A.; Rashkin, S. R.; Ma, J.; Cheng, Y.
10.1101/2025.02.10.637517 — genomics — Posted on 2025-02-12
2989 Dissecting the RNA binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport
Stoffel, N. K.; Sankaranarayanan, S.; Muentjes, K.; Busch, A.; Koenig, J.; Zarnack, K.; Feldbruegge, M.
10.1101/2025.02.12.636894 — molecular biology — Posted on 2025-02-12
2990 DNA G-quadruplex Profiling Reveals Functional and Mechanistic Role of G-quadruplexes in Skeletal Muscle Stem Cells
Chen, X.; Yang, F.; Zhang, S.; Guo, X.; Zhao, J.; Qiao, Y.; He, L.; Li, Y.; Zhou, Q.; Ong, M. T. Y.; Kwok, C. K.; Sun, H.; Wang, H.
10.1101/2025.02.10.637367 — molecular biology — Posted on 2025-02-12
2991 Discovery of widespread activating mutations in a compact RNA-guided endonuclease
Thornton, B. W.-L.; Weissman, R. F.; Tran, R. V.; Duong, B. T.; Rodriguez, J. E.; Terrace, C. I.; Groover, E. D.; Park, J.-U.; Tartaglia, J.; Doudna, J. A.; Savage, D.
10.1101/2025.02.11.637750 — molecular biology — Posted on 2025-02-12
2992 Cystinosin is involved in Na+/H+ Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis
Khare, V.; Farre, J. C.; Rocca, C.; Kbaich, M. A.; Tang, C.; Ma, X.; Biederman, K.; Mathur, I.; Grau, R. A. B.-; Sivakumar, A.; Chen, R.; Catz, S. D.; Cherqui, S.
10.1101/2025.02.12.637793 — molecular biology — Posted on 2025-02-12
2993 A bioinformatic workflow to facilitate the study of less-understood proteins: the case of SH2D2A
Gilmour, B. C.; Chan, H.; Singh, S.; Nyman, T. A.; Borowicz, P.; Phuyal, S.; Spurkland, A.
10.1101/2025.02.11.637442 — molecular biology — Posted on 2025-02-12
2994 Merkel cell polyomavirus infection and persistence modelled in skin organoids
Albertini, S.; Czech-Sioli, M.; Guenther, T.; Virdi, S.; Bluemke, P.; Roepke, L.; Brinschwitz, V.; Dandri, M.; Allweiss, L.; Reimer, R.; Schneider, C.; Hansen, A.; Krasemann, S.; Wyler, E.; Landthaler, M.; Grundhoff, A.; Fischer, N.
10.1101/2025.02.11.637697 — molecular biology — Posted on 2025-02-12
3000 From sporulation to village differentiation: the shaping of the social microbiome over rural-to-urban lifestyle transition in Indonesia
Febinia, C. A.; Luqman, H.; Kusuma, P.; Priliani, L.; Lewis, J.; Wihandani, D. M.; Pinatih, G. N. I.; Sudoyo, H.; Almeida, A.; Malik, S. G.; Jacobs, G.
10.1101/2025.02.12.637485 — microbiology — Posted on 2025-02-12
3005 Discovery of microbial glycoside hydrolases via enrichment and metaproteomics
van Ede, J. M.; van der Steen, S.; van der Kraan, G. M.; van Loosdrecht, M. C. M.; Pabst, M.
10.1101/2025.02.11.637619 — ecology — Posted on 2025-02-12
3008 Identification of the Inducible HIV reservoir in Tonsillar, Intestinal and Cervical Tissue Models of HIV Latency
Cortes, A. G.; Gaona, N. S.; Perez, C. M.; Isant, O. R.; Martinez, A. B.; Landolfi, S.; Castellvi, J.; Pumarola, F.; Ortiz, N.; Llano, I.; Lorente, J.; Barrachina, L. M.; Prado, J. G.; Gayo, E. M.; Ferrer, V. F.; Ferrer, M. G.; Gomez, M. J. B.
10.1101/2025.02.10.637439 — immunology — Posted on 2025-02-12
3009 In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long-lasting transcriptomic and proteomic changes
Hartmann, V.; Guo, S.; Rahimi, S.; Radine, U.; Malheiros, D.; Salviano-Silva, A.; Bumiller-Bini Hoch, V.; Cipolla, G. A.; Calonga-Solis, V.; Künstner, A.; Burmester, I.; Ludwig, R. J.; Hariton, W. V. J.; Hammers, C. M.; Müller, E. J.; Busch, H.; Hundt, J. E.
10.1101/2025.02.10.637416 — immunology — Posted on 2025-02-12
3011 Semiparametric Confidence Sets for Arbitrary Effect Sizes in Longitudinal Neuroimaging
Zhang, X.; Liao, K.; Seidlitz, J.; McHugo, M.; Avery, S. N.; Huang, A.; Alexander-Bloch, A.; Woodward, N.; Heckers, S.; Vandekar, S.
10.1101/2025.02.10.637497 — neuroscience — Posted on 2025-02-12
3013 Wearable MEG data recorded during human stepping
Spedden, M. E.; O'Neill, G. C.; West, T.; Tierney, T. M.; Mellor, S. J.; Alexander, N.; Seymour, R.; Lundbye-Jensen, J.; Nielsen, J. B.; Farmer, S.; Bestmann, S.; Barnes, G.
10.1101/2025.02.11.637004 — neuroscience — Posted on 2025-02-12
3014 Astrocytic PI3Kα controls synaptic plasticity and cognitive function via serine metabolism
Fernandez-Rodrigo, A.; Garcia-Vilela, C.; Eraso-Pichot, A.; Lopez-Merino, E.; Maroto, I. B.; Gutierrez-Eisman, S.; Sanchez-Castillo, C.; Boers-Escuder, C.; Merino-Casamayor, E.; Graupera, M.; Cuartero, M. I.; Quintana, A.; Marsicano, G.; Esteban, J. A.
10.1101/2025.02.11.637597 — neuroscience — Posted on 2025-02-12
3015 Annotation Comparison Explorer (ACE): connecting brain cell types across studies of health and Alzheimer's Disease
Miller, J. A.; Travaglini, K. J.; Luquez, T.; Hostetler, R. E.; Oster, A.; Daniel, S.; Tasic, B.; Menon, V.
10.1101/2025.02.11.637559 — neuroscience — Posted on 2025-02-12
3016 Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision
Rahmati, M.; Moujaes, F.; Suljic, N. P.; Ji, J. L.; Berkovitch, L.; Lee, K.; Fonteneau, C.; Schleifer, C. H.; Adkinson, B. D.; Savic, A.; Santamauro, N.; Tamayo, Z.; Diehl, C.; Kolobaric, A.; Flynn, M.; Camarro, T.; Curtis, C. E.; Repovs, G.; Fineberg, S. K.; Morgan, P. T.; Preller, K. H.; Krystal, J. H.; Murray, J. D.; Cho, Y. T.; Anticevic, A.
10.1101/2025.02.10.637233 — neuroscience — Posted on 2025-02-12
3019 When Group Means Fail: Can One Size Fit All?
Grandy, T. H.; Lindenberger, U.; Werkle-Bergner, M.
10.1101/126490 — neuroscience — Posted on 2025-02-12
3024 Arabidopsis PIEZO regulates magnetic field-mediated root growth under blue light
Ai, P. Z.; Jing, Y. W.; Man, D.; Rui, B. H.; Yan, L.; Hui, P. N.; Yong, X.; Wei, G. L.; ning, L. C.; Long, D. Y.
10.1101/2025.02.11.637623 — plant biology — Posted on 2025-02-12
3025 The minor antennae of photosystem II contribute to qH-energy dissipation in Arabidopsis
Bru, P.; Crepin, A.; Provot, Y.; Guardini, Z.; Bassi, R.; Dall'Osto, L.; Malnoe, A.
10.1101/2025.02.11.637767 — plant biology — Posted on 2025-02-12
3031 Enhanced Neural Plasticity of the Primary Visual Cortex in Visual Snow Syndrome: Evidence from MEG Gamma Oscillations
Orekhova, E. V.; Naumova, S. M.; Obukhova, T. S.; Plieva, A. M.; Prokofyev, A. O.; Petrokovskaia, A. V.; Artemenko, A. R.; Stroganova, T. A.
10.1101/2025.02.12.637794 — neuroscience — Posted on 2025-02-12
3032 Axonal Mechanotransduction Drives Cytoskeletal Responses to Physiological Mechanical Forces
Swaim, G. L.; Glomb, O.; Xie, Y.; Emerson, C.; Li, Z.; Beaudet, D.; Hendricks, A. G.; Yogev, S.
10.1101/2025.02.11.637689 — neuroscience — Posted on 2025-02-12
3033 Ankyrins are essential for synaptic integrity of photoreceptors in the mouse outer retina
Zuniga-Sanchez, E.; Perez, R. M.; Campbell, J.; Goswami-Sewell, D.; Venkatraman, R.; Gomez, C. C.; Bagnetto, C.; Lee, A.; Mattos, M. F.; Hoon, M.
10.1101/2025.02.11.637690 — neuroscience — Posted on 2025-02-12
3034 Spike sorting AI agent
Lin, Z.; Marin-Llobet, A.; Baek, J.; He, Y.; Lee, J.; Wang, W.; Zhang, X.; Lee, A. J.; Liang, N.; Du, J.; Ding, J.; Li, N.; Liu, J.
10.1101/2025.02.11.637754 — neuroscience — Posted on 2025-02-12
3038 Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons
Kroll, J.; Kravcenko, U.; Sadeghi, M.; Diebolder, C. A.; Ivanov, L.; Lubas, M.; Sprink, T.; Schacherl, M.; Kudryashev, M.; Rosenmund, C.
10.1101/2025.02.11.635788 — neuroscience — Posted on 2025-02-12
3039 Mapping Anhedonia-Related Damage Network: Insights for TMS Treatment
Chen, C.; Wang, S.; Liu, Y.; Zhang, X.; Rong, X.; Wang, J.; Wang, J.; Sun, L.; Zhang, B.
10.1101/2025.02.11.637479 — neuroscience — Posted on 2025-02-12
3042 Rearing conditions bidirectionally modulate cognitive abilities and AP-1 signaling in hippocampal neurons in a cell type-specific manner.
Alaiz-Noya, M.; Miozzo, F.; Fuentes-Ramos, M.; Machnicka, M.; Kurowska, M.; Herrera, M. L.; del Blanco, B.; Ninerola, S.; Bustos-Martinez, I.; Wilczynski, B.; Barco, A.; Barco, A.
10.1101/2025.02.11.637399 — neuroscience — Posted on 2025-02-12
3045 Incorporation of complex narratives into dreaming
Palmieri, J.; Kumral, D.; Wymer, S.-J.; Kirchner, S.; Schneider, M.; Gais, S.; Schoenauer, M.
10.1101/2025.02.11.637675 — neuroscience — Posted on 2025-02-12
3046 Time-to-onset and temporal dynamics of EEG during breath-watching meditation
Malipeddi, S.; Sasidharan, A.; Venugopal, R.; Tewarie, P. K. B.; P.N., R.; Northoff, G.; Laureys, S.; Subramaniam, B.; Kutty, B. M.
10.1101/2025.02.11.637771 — neuroscience — Posted on 2025-02-12
3047 Presaccadic modulation of lateral interactions
Mueller de Melo, G.; de Oliveira Pitorri, I.; Rohenkohl, G.
10.1101/2025.02.10.637412 — neuroscience — Posted on 2025-02-12
3048 Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease
Caredio, D.; Mariutti, G.; Cerisoli, M.; Polzer, L.; Laimeche, Y.; Miracca, G.; Emmenegger, M.; Schmitz, M.; Zerr, I.; De Cecco, E.; Aguzzi, A.
10.1101/2025.02.11.637592 — neuroscience — Posted on 2025-02-12
3049 Identification of V0g propriospinal neurons and their role in locomotor control
Toscano, E.; Giomi, M.; Evtushenko, N.; Santuz, A.; Lowenstein, E. D.; Birchmeier, C.; Zampieri, N.
10.1101/2025.02.11.636221 — neuroscience — Posted on 2025-02-12
3051 High Tau Expression Correlates with Reduced Invasion and Prolonged Survival in Ewing Sarcoma
Cidre-Aranaz, F.; Magrin, C.; Zimmermann, M.; Li, J.; Baffa, A. L.; Ciccaldo, M.; Hartmann, W.; Dirksen, U.; Sola, M.; Paganetti, P.; Gruenewald, T. G. P.; Papin, S.
10.1101/2025.02.10.635652 — cancer biology — Posted on 2025-02-12
3053 MilkOligoCorpus: a semantically annotated resource for knowledge extraction on mammalian milk oligosaccharides
Rumeau, M.; Courtin, M.; Bossy, R.; Sauvion, C.; Loux, V.; Ba, M.; Knudsen, C.; Combes, S.; Nedellec, C.; Deleger, L.
10.1101/2025.02.09.637314 — bioinformatics — Posted on 2025-02-12
3055 Acoustofluidic patterning for improved microtissue histology
Deshmukh, D.; Vuille-dit-Bille, E.; Joshi, S.; Gerber, N.; Fux, C.; Eichenberger, A.; Bono, E.; Rimann, M.; Heub, S.; Migliozzi, D.; Boder-Pasche, S.; Weder, G.; Dual, J.; Tibbitt, M. W.
10.1101/2025.02.09.637288 — bioengineering — Posted on 2025-02-12
3057 Investigating the Role of Onchocerca ochengi in Epilepsy Development: A Gerbil Model Study
Ayiseh, R. B.; Ulrick, A. F.; Etaka, J. C.; Dobgima, G. S.; Njobinkir, B. C.; Ghogomu, S. M.; Cho-Ngwa, F.
10.1101/2025.02.10.637387 — neuroscience — Posted on 2025-02-12
3058 Hemispherotomy: a cortical island of sleep-like activity in awake humans
Colombo, M. A.; Favaro, J.; Mikulan, E.; Pigorini, A.; Zauli, F. M.; Sartori, I.; d'Orio, P.; Castana, L.; Toldo, I.; Sartori, S.; Sarasso, S.; Bayne, T.; Seth, A.; Massimini, M.
10.1101/2025.02.10.637383 — neuroscience — Posted on 2025-02-12
3061 Short- and long-term effects of uterine disease on oocyte developmental capacity in postpartum dairy cows
Caldeira, M.; McDonald, K.; Martinez, E.; Moraes, J.; Sellmer Ramos, I.; Poock, S.; Ortega, M. S.; Lucy, M.
10.1101/2025.02.07.636469 — physiology — Posted on 2025-02-12
3062 Resting calcium ion fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming
Fecher, C.; Sodmann, A.; Schlott, F.; Jaepel, J.; Schmitt, F.; Lengfelder, I.; Bischler, T.; Nieswandt, B.; Winklhofer, K. F.; Blum, R.
10.1101/2025.02.06.636834 — physiology — Posted on 2025-02-12
3063 Combinatorial effects of Zingiber officinale and Citrus limon juices: Hypolipidemic and antioxidant insights from in vivo, in vitro, and in silico investigations
Bekkouch, O.; Bekkouch, A.; Elbouny, H.; Touiss, I.; El Assri, S.; Choukri, M.; Bourhia, M.; Kim, K.; Kang, S.; Choi, M.; Choi, J.; Kim, H. J.; Ahn, C.-H.; Park, M. N.; Kim, B.; Amrani, S.
10.1101/2025.02.08.637272 — pharmacology and toxicology — Posted on 2025-02-12
3064 Direct-view oblique plane microscopy
Lamb, J. R.; Cardoso Mestre, M.; Lancaster, M. A.; Manton, J. D.
10.1101/2025.02.11.635467 — biophysics — Posted on 2025-02-12
3067 Inference of human pigmentation from ancient DNA by genotype likelihood
Perretti, S.; Vizzari, M. T.; Santos, P.; Tassani, E.; Benazzo, A.; Ghirotto, S.; Barbujani, G.
10.1101/2025.01.29.635495 — genomics — Posted on 2025-02-12
3070 Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis
Ma, X.; Wei, X.; Niu, m.; Zhang, C.; Peng, Z.; Liu, W.; Yan, J.; Su, X.; Lu, S.; Cui, W.; Sesaki, H.; Zong, W.-X.; Ni, H.-M.; Ding, W.-X.
10.1101/2025.02.11.637688 — cell biology — Posted on 2025-02-12
3071 CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
Miller, W. D.; Mishra, A. K.; Sheedy, C. J.; Bond, A.; Gardner, B. M.; Montell, D. J.; Morrissey, M. A.
10.1101/2025.02.11.637707 — cell biology — Posted on 2025-02-12
3072 Hoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis
Dziurdzik, S. K.; Sridhar, V.; Eng, H.; Neuman, S. D.; Yan, J.; Davey, M.; Taubert, S.; Bashirullah, A.; Conibear, E.
10.1101/2025.02.11.637747 — cell biology — Posted on 2025-02-12
3073 TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction
Mamede, L. D.; Hu, M.; Titus, A. R.; Vaquer-Alicea, J.; French, R. L.; Diamond, M. I.; Miller, T. M.; Ayala, Y. M.
10.1101/2025.02.11.637743 — cell biology — Posted on 2025-02-12
3074 Elimination of separase inhibition reveals absence of cohesin protection in oocyte metaphase II
El Jailani, S.; Cladiere, D.; Nikalayevich, E.; Touati, S. A.; Chesnokova, V.; Melmed, S.; Buffin, E.; Wassmann, K.
10.1101/2025.02.11.637638 — cell biology — Posted on 2025-02-12
3075 The NIH BRAIN Initiative's Experiment in Team Research
Bader, F.; David, K. K.; Lantz, C.; Rangel-Gomez, M.; Gebrehiwet, H.; Peng, G. C. Y.; Gnadt, J.
10.1101/2025.02.07.635683 — neuroscience — Posted on 2025-02-12
3076 Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike
Oliveira, A. S. F.; Kearns, F. L.; Rosenfeld, M. A.; Casalino, L. F.; Tulli, L.; Berger, I.; Schaffitzel, C.; Davidson, A. D.; Amaro, R. E.; Mulholland, A. J.
10.1101/2023.11.06.565757 — biochemistry — Posted on 2025-02-12
3078 Enabling the Study of Gene Function in Gymnosperms: VIGS in Ephedra tweedieana
Garcia, A. G.; Bui, J. T.; Michael, T. P.; Ickert-Bond, S. M.; Di Stilio, V. S. S.
10.1101/2025.02.07.637168 — plant biology — Posted on 2025-02-12
3081 Pregranulosa cells engage a distinct transcriptional programme prior to cell-cycle dependent primordial follicle activation
Taylor, G.; Frost, E. R.; Crow, B. N.; Radley, A.; Boeing, S.; Galichet, C.; Bucinskaite, B.; Baker, M. A.; Sutherland, J. M.; Lovell-Badge, R.
10.1101/2022.10.24.513438 — developmental biology — Posted on 2025-02-12
3082 CD2 expression is co-regulated with stemness- and exhaustion-associated factors in human T cells
Demetriou, P.; Iakovou, M.; Gregoriou, G.; Vrachnos, D.; Chi, J.; Tamamouna, V.; Constantinou, S.; Papanastasiou, V.; Antoniades, A.; Costeas, P.
10.1101/2025.01.10.632071 — immunology — Posted on 2025-02-12
3084 Identification and Pharmacological Targeting of Treatment-Resistant, Stem-like Breast Cancer Cells for Combination Therapy
Worley, J.; Noh, H.; You, D.; Turunen, M.; Ding, H.; Paull, E. O.; Griffen, A.; Grunn, A.; Zhang, M.; Guillan, K.; Bush, E.; Brosius, S.; Hibshoosh, H.; Mundi, P. S.; Sims, P.; Dalerba, P.; Dela Cruz, F. S.; Kung, A. L.; Califano, A.
10.1101/2023.11.08.562798 — systems biology — Posted on 2025-02-12
3085 A perturbation proteomics-based foundation model for virtual cell construction
Sun, R.; Qian, L.; Li, Y.; Cheng, H.; Xue, Z.; Zhang, X.; Tan, L.; Zhan, Y.; Hu, W.; Xiao, Q.; Liu, Z.; Zhang, G.; E, W.; Zhou, P.; Wen, H.; Zhu, Y. J.; Guo, T.
10.1101/2025.02.07.637070 — systems biology — Posted on 2025-02-12
3087 TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer.
Morano, L.; Vie, N.; Aissanou, A.; Egger, T.; Aze, A.; Fiachetti, S.; Seitz, H.; Milazzo, L.-A.; GARAMBOIS, V.; Bonnefoy-Berard, N.; Gongora, C.; Constantinou, A.; Basbous, J.
10.1101/2024.09.10.612204 — cancer biology — Posted on 2025-02-12
3088 Reinforced identity confers cells with cancer hallmarks
Yang, H.; Wang, P.; Tan, P.; Xue, Q.; Wu, H.; He, K.; Wang, B.; Wang, D.; Ma, T.; Ding, S.
10.1101/2024.11.01.621626 — cancer biology — Posted on 2025-02-12
3089 AI-qualizing Science
Divakaruni, A.; Bares, F.; Phalippou, L.
10.1101/2025.02.11.637417 — bioinformatics — Posted on 2025-02-12
3092 ERGA-BGE genome of Coenonympha oedippus: an IUCN endangered European butterfly species occurring in two ecotypes
Celik, T.; Lokovsek, T.; Buzan, E.; Boehne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Gut, M.; Aguilera, L.; Camara Ferreira, F.; Cruz Rodriguez, F.; Gomez-Garrido, J.; Alioto, T. S.; Bortoluzzi, C.
10.1101/2025.02.10.637396 — genomics — Posted on 2025-02-12
3093 How to measure bacterial genome plasticity? A novel time-integrated index helps gather insights on pathogens
Bellinzona, G.; Batisti Biffignandi, G.; Baldanti, F.; Brilli, M.; Sassera, D.; Gaiarsa, S.
10.1101/2024.01.22.576626 — genomics — Posted on 2025-02-12
3094 Mitochondrial Deletions and Healthspan: Lessons from the Common Repeat
Shamanskiy, V. A.; Gunbin, K. V.; Tretiakov, E. O.; Mazunin, I. O.; Skripskaya, V.; Mihailova, A. A.; Mikhailova, A. G.; Ree, N.; Timonina, V.; Knorre, D.; Kunz, W. S.; Fiorellino, N.; Reymond, A.; Bazykin, G. A.; Fellay, J.; Tanaka, M.; Khrapko, K.; Popadin, K.
10.1101/2024.09.02.610808 — genetics — Posted on 2025-02-12
3097 First detection of Crimean Congo Hemorrhagic Fever antibodies in cattle and wild fauna of southern continental France: investigation of explicative factors
Bernard, C.; Apolloni, A.; Grosbois, V.; Peyraud, A.; Saengram, P.; JORI, F.; Faure, E.; Keck, N.; Pin, R.; Ferraris, O.; Comtet, L.; Combes, B.; Bastien, M.; Chauvin, V.; Guerrini, L.; Holzmuller, P.; Vial, L.
10.1101/2025.02.06.636810 — ecology — Posted on 2025-02-12
3098 Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway
He, X.; Zhang, H.; Wang, Y.; Yan, H.; Chen, Q.; Su, M.; Shi, Q.; Zeng, X.; Sheng, W.; Wang, Y.; Wang, C.; Hou, S.; Hu, Z.; He, Y.; Wang, X.
10.1101/2025.02.11.637629 — developmental biology — Posted on 2025-02-12
3100 Identifying Neurobiological Psychosis Biotypes Using Multi-Scale Functional Network Connectivity and its Latent Independent Subspace
Ballem, R.; Camazon, P. A.; Jensen, K. M.; Bajracharya, P.; Diaz-Caneja, C. M.; Bustillo, J. R.; Turner, J. A.; Pearlson, G. D.; Chen, J.; Calhoun, V.; Iraji, A.
10.1101/2025.02.11.637551 — neuroscience — Posted on 2025-02-12
3101 Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults
Klingelhoefer-Jens, M.; Hutterer, K.; Schiele, M. A.; Leehr, E. J.; Schuemann, D.; Rosenkranz, K.; Boehnlein, J.; Repple, J.; Deckert, J.; Domschke, K.; Dannlowski, U.; Lueken, U.; Reif, A.; Romanos, M.; Zwanzger, P.; Pauli, P.; Gamer, M.; Lonsdorf, T. B.
10.1101/2023.09.26.559474 — neuroscience — Posted on 2025-02-12
3102 A vertical stacking approach to rapid generation cycling for indoor growth of tall annual crops - the case of Vicia faba
Pazos Navarro, M.; Bennett, R. G.; Munday, C.; Creasy, R.; Catt, S. C.; Lichtenzveig, J.; Ribalta, F.; Croser, J.
10.1101/2025.02.09.637347 — plant biology — Posted on 2025-02-12
3103 Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancer
Mukund, K.; Veraksa, D.; Frankhouser, D.; Yang, L.; Tomsic, J.; Pillai, R.; Atti, S.; Mesrizadeh, Z.; Schmolze, D.; Wu, X.-C.; LeBlanc, M.-A.; Miele, L.; Ochoa, A.; Seewaldt, V.; Subramaniam, S.
10.1101/2025.02.10.637503 — cancer biology — Posted on 2025-02-12
3105 Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens
Dufort, F. J.; Leitheiser, C. J.; Rezvaya, A.; Ezell, T. R.; Ho, K. Q.; Bezerra, G. A.; Blakeman, B. J.; Uhlenbroich, S.; Zammit, W. H.; Stanczuk, L.; Brown, P. N.; Mudd, G. E.; McDonnell, K.; Keen, N.; Brandish, P.
10.1101/2024.10.30.621052 — cancer biology — Posted on 2025-02-12
3107 Semi-supervised Omics Factor Analysis (SOFA) disentangles known and latent sources of variation in multi-omic data
Capraz, T.; Vöhringer, H.; Huber, W.; Kruger Serrano, K. S. A.; Ramirez Flores, R. O.; Saez-Rodriguez, J.
10.1101/2024.10.10.617527 — bioinformatics — Posted on 2025-02-12
3108 Risk Prediction of RNA Off-Targets of CRISPR Base Editors in Tissue-Specific Transcriptomes Using Language Models
Nakamae, K.; Suzuki, T.; Yonezawa, S.; Yamamoto, K.; Kakuzaki, T.; Ono, H.; Naito, Y.; Bono, H.
10.1101/2025.01.19.633823 — genomics — Posted on 2025-02-12
3109 Evaluating Variants of Uncertain Significance in Adult Knock-in Zebrafish: A Proof of Concept with a COL1A2 Variant
Vanhooydonck, M.; Debaenst, S.; Vanbelleghem, E.; De Saffel, H.; Syx, D.; Sips, P.; Coucke, P. J.; Willaert, A.; Callewaert, B.
10.1101/2025.02.11.637642 — genetics — Posted on 2025-02-12
3110 HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
Li, H.; Zhang, X.; Li, S.; Cui, Z.; Zhao, X.; Ma, H.; Xu, M.; Xu, Y.; Liang, X.; Zha, B.; Lv, L.; Wang, K.
10.1101/2024.09.29.615677 — cell biology — Posted on 2025-02-12
3112 Motivational control is implemented by a cingulo-prefrontal pathway
Gandaux, C.; Sallet, J.; Amiez, C.; Autran-Clavagnier, D.; Morel-Latour, V.; Goussi-Denjean, C.; Fontanier, V.; Misery, P.; Lamy, C.; Lamberton, F.; Lavigne, M.; Kremer, E. J.; Wislon, C. R. E.; Procyk, E.
10.1101/2025.02.11.637635 — neuroscience — Posted on 2025-02-12
3113 Functional specialisation of multisensory temporal integration in the mouse superior colliculus
Bianchini, G.; Razafindrahaba, I.; Moglie, M. J.; Konstantinou, G.; Cano-Ferrer, X.; Imbert, A.; Iacaruso, F.
10.1101/2025.02.11.637674 — neuroscience — Posted on 2025-02-12
3115 TMEM145 is a key component in stereociliary link structures of outer hair cells
Roh, J. W.; Oh, K. S.; Lee, J.; Choi, Y.; Kim, S.; Hong, J. W.; Kim, Y.; Lew, H.; Jang, S. H.; Shin, H.-S.; Ohk, J.; Jung, H.; Seo, K. Y.; Bok, J.; Kim, C. H.; Gee, H. Y.
10.1101/2025.02.10.637577 — neuroscience — Posted on 2025-02-12
3121 A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis
Ishikawa, G.; Peng, X.; Ghincea, A.; McGovern, J.; Zielonka, J.; Jeevanandam, A.; Shao, S.; Woo, S.; Okuno, D.; Yu, S.; Lee, C. J.; Liu, A.; Saber, T.; Hu, B.; Sun, Y.; Gao, R.; Jumaily, K. A.; Homer, R.; Hinchcliff, M.; Feghali-Bostwick, C.; Sumida, T. S.; Sauler, M.; Gomez, J. L.; Sun, H.; Ryu, C.; Herzog, E. L.
10.1101/2024.09.09.611003 — cell biology — Posted on 2025-02-11
3122 Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model
Long, R. K. M.; Korbmacher, F.; Ronchi, P.; Fleckenstein, H.; Schorb, M.; Mirza, W.; Mallorqui, M.; Aguilar, R.; Moncunill, G.; Schwab, Y.; Bernabeu, M.
10.1101/2024.03.29.587334 — microbiology — Posted on 2025-02-11
3123 Migration and standing variation in vaginal and rectal yeast populations in recurrent vulvovaginal candidiasis
Adamu Bukari, A.-R.; Kukurudz-Gorowski, R.; de Graaf, A.; Habon, D.; Manyaz, B.; Syvolos, Y.; Sumanarathnea, A.; Poliquin, V.; Gerstein, A. C.
10.1101/2023.07.19.549743 — microbiology — Posted on 2025-02-11
3124 CRISPR/dCas-mediated counter-silencing: Reprogramming dCas proteins into antagonists of xenogeneic silencers
Wiechert, J.; Badia Roige, B.; Dohmen-Olma, D.; Hindra, H.; Zhang, X.; Elliot, M.; Frunzke, J.
10.1101/2024.08.29.610263 — microbiology — Posted on 2025-02-11
3125 T follicular helper cell profiles differ by malaria antigen and for children compared to adults
Forconi, C. S.; Nixon, C.; Wu, H. W.; Odwar, B.; Pond-Tor, S.; Ong'echa, J. M.; Kurtis, J. D.; Moormann, A. M.
10.1101/2024.04.13.589352 — immunology — Posted on 2025-02-11
3128 CD33KO-CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia
Wang, Y.; Zheng, X.; Wang, Z.; Xiao, Z.; Lin, Y.; Zhang, F.; Liu, Y.; Liu, P.; Weng, Q.; Zhang, L.; Xia, C.; Huang, D.; Liu, L.; Zhu, Y.; Zhang, Q.; Qi, H.; Chen, Y.; Shen, Y.; Zhang, C.; Xu, J.; Zhao, Y.; Wu, J.; Wang, T.; Zhang, M.; Li, M.; Qian, W.; Liang, A.; Du, X.; Yang, W.; Chen, Q.; Zhu, X.; Hu, F.; Wang, J.
10.1101/2025.01.23.634500 — cancer biology — Posted on 2025-02-11
3131 The Structure of the Drp1 Lattice on Membrane
Peng, R.; Rochon, K.; Hutson, A. N.; Stagg, S.; Mears, J. A.
10.1101/2024.04.04.588123 — biochemistry — Posted on 2025-02-11
3132 Scalable Screening of Ternary-Code DNA methylation Dynamics Associated with Human Traits.
Goldberg, D. C.; Cloud, C.; Lee, S. M.; Barnes, B.; Gruber, S.; Kim, E.; Pottekat, A.; Westphal, M. S.; McAuliffe, L.; Majournie, E.; KalayilManian, M.; Zhu, Q.; Tran, C.; Hansen, M.; Stojakovic, J.; Parker, J. B.; Kohli, R. M.; Porecha, R.; Renke, N.; Zhou, W.
10.1101/2024.05.17.594606 — genomics — Posted on 2025-02-11
3133 rbfox1 loss in zebrafish drives HPI axis hyperactivation via bdnf/trkb2 pathway and allostatic overload during later life
Leggieri, A.; Judit Garcia-Gonzalez, J.; Hosseinian, S.; Ashdown, P.; Anagianni, S.; Wang, X.; Havelange, W.; Fernandez-Castillo, N.; Cormand, B.; Brennan, C. H.
10.1101/2024.10.09.616976 — genetics — Posted on 2025-02-11
3134 Genomic insights reveal community structure and phylogenetic associations of endohyphal bacteria and viruses in fungal endophytes
Escudero Leyva, E.; Belle, M.; DadkhahTehrani, A.; Culver, J. N.; Araya Salas, M.; Kutza, J. P.; Goldson, N.; Chavarria, M.; Chaverri, P.
10.1101/2025.02.07.637084 — ecology — Posted on 2025-02-11
3135 Tree nursery environments and their effect on early trait variation
Perry, A.; Beaton, J. K.; Stockan, J. A.; Iason, G. R.; Cottrell, J. E.; Cavers, S.
10.1101/2024.08.20.608769 — ecology — Posted on 2025-02-11
3137 Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila
Dong, P.; Li, Y.; Wang, Y.; Zhao, Q.; Lu, T.; Chen, J.; Guo, T.; Ma, J.; Yang, B.; Wu, H.; Huang, H.
10.1101/2024.07.03.601877 — developmental biology — Posted on 2025-02-11
3138 BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM
Hanna, M. G.; Rodriguez Cruz, H. O.; Fujise, K.; Wu, Y.; Xu, C. S.; Pang, S.; Zhuoning, L.; Monetti, M.; De Camilli, P.
10.1101/2024.09.28.615015 — cell biology — Posted on 2025-02-11
3140 Anti-resonance in developmental signaling regulates cell fate decisions
Rosen, S. J.; Witteveen, O.; Baxter, N.; Lach, R. S.; Bauer, M.; Wilson, M. Z.
10.1101/2025.02.04.636331 — cell biology — Posted on 2025-02-11
3141 Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft Versus Host disease onset
Le Grand, S.; Marie, Y.; Bouteiller, D.; Robert, E.; Peffault de Latour, R.; Socie, G.; Vallet, N.; Michonneau, D.
10.1101/2025.01.12.632608 — molecular biology — Posted on 2025-02-11
3142 Loss of AATF ameliorates metabolic dysfunction-associated steatohepatitis by suppressing the AKT-mTORC1 signaling pathway
N. Srinivas, A.; Suresh, D.; Anirvan, P.; Moorthy, M.; Ramaswamy, G.; Nataraj, S. M.; Santhekadur, P. K.; Suvarna, D.; Singh, S. P.; Kumar, D. P.
10.1101/2024.05.25.595878 — molecular biology — Posted on 2025-02-11
3144 Processing of Clostridium perfringens Enterotoxin by Intestinal Proteases
Shrestha, A.; Gonzales, J. L.; Beingesser, J.; Uzal, F. A.; McClane, B.
10.1101/2025.02.11.637699 — microbiology — Posted on 2025-02-11
3145 Non-cyanobacterial diazotrophs from the Rhizobiales order support marine microalgae in nitrogen-depleted environments
Chandola, U.; Trottier, C.; Gaudin, M.; Lavier Aydat, L. J.; Manirakiza, E.; Menicot, S.; Fischer, E. J.; Louvet, I.; Lacour, T.; Chaumier, T.; Tanaka, A.; Pohnert, G.; Chaffron, S.; Tirichine, L.
10.1101/2022.08.25.505241 — microbiology — Posted on 2025-02-11
3146 High-Fidelity Long-Read Sequencing of an Avian Herpesvirus Reveals Extensive Intrapopulation Diversity in Tandem Repeat Regions
Ortigas-Vasquez, A.; Bowen, C. D.; Renner, D. W.; Baigent, S. J.; Zhang, Y.; Yao, Y.; Nair, V.; Kennedy, D. A.; Szpara, M. L.
10.1101/2025.02.10.637388 — microbiology — Posted on 2025-02-11
3147 Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex
Glasner, D. R.; Todd, C.; Cook, B.; D'Urso, A.; Khosla, S.; Estrada, E.; Wagner, J. D.; Bartels, M. D.; Ford, P.; Prych, J.; Hatch, K.; Yee, B. A.; Ego, K. M.; Liang, Q.; Holland, S. R.; Case, J. B.; Corbett, K. D.; Diamond, M. S.; Yeo, G. W.; Herzik, M. A.; Van Nostrand, E. L.; Daugherty, M. D.
10.1101/2025.02.11.637299 — microbiology — Posted on 2025-02-11
3148 Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization
He, L.; Patkowski, J. B.; Miguel-Romero, L.; Aylett, C. H. S.; Fillol-Salom, A.; Costa, T. R. D.; Penades, J. R.
10.1101/2025.02.11.637232 — microbiology — Posted on 2025-02-11
3151 A vector calculus for neural computation in the cerebellum
Fakharian, M. A.; Shoup, A.; Hage, P.; Elseweifi, H.; Shadmehr, R.
10.1101/2024.11.14.623565 — neuroscience — Posted on 2025-02-11
3152 Cell-specific inhibitory modulation of sound processing in the auditory thalamus.
Rolon-Martinez, S.; Mendoza, A. J.; Angeloni, C. F.; Chen, R.; Vu, K.; Haas, J. S.; Geffen, M. N.
10.1101/2024.06.29.601250 — neuroscience — Posted on 2025-02-11
3155 Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases
Chakraborty, A.; Mitra, J.; Malojirao, V. H.; Kodavati, M.; Mandal, S. M.; Gill, S. K.; Sreenivasmurthy, S. G.; Vasquez, V.; Mankevich, M.; Krishnan, B.; Ghosh, G.; Hegde, M.; Hazra, T.
10.1101/2024.11.13.623464 — neuroscience — Posted on 2025-02-11
3159 Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function
Ramos, A. S.; Simon, S.; Siller-Farfan, J.; Rajan, A.; Revale, S.; Zanchini di Castiglionchio, E.; Pelea, O.; Fulga, T. A.; Riddell, S.; Dushek, O.; Michaels, Y. S.; Sauka-Spengler, T.
10.1101/2025.02.10.637482 — synthetic biology — Posted on 2025-02-11
3160 A Putative Binding Model of Nitazene Derivatives at the mu-Opioid Receptor
Clayton, J.; Shi, L.; Skiniotis, G.; Robertson, M. J.; Michaelides, M.; Stavitskaya, L.; Shen, J.
10.1101/2024.10.03.616560 — biophysics — Posted on 2025-02-11
3161 Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors
Schahl, A.; Lagardere, L.; Walker, B.; Ren, P.; Wioland, H.; Ballet, M.; JEGOU, A.; Chavent, M.; Piquemal, J.-P.
10.1101/2022.12.16.520803 — biophysics — Posted on 2025-02-11
3163 Ontology-based modeling, integration, and analysis of heterogeneous clinical, pathological, and molecular kidney data for precision medicine
He, Y.; Barisoni, L.; Rosenberg, A. Z.; Robinson, P. N.; Diehl, A. D.; Chen, Y.; Phuong, J. P.; Hansen, J.; Herr, B. W.; Borner, K.; Bonevich, N.; Arnous, G.; Boddapati, S.; Zheng, J.; Alakwaa, F.; Sarder, P.; Duncan, W. D.; Liang, C.; Valerius, M. T.; Jain, S.; Iyengar, R.; Himmelfarb, J.; Kretzler, M.; Kidney Precision Medicine Project,
10.1101/2024.04.01.587658 — bioinformatics — Posted on 2025-02-11
3164 Decoding protein language models: insights from embedding space analysis
Rissom, P. F.; Yanez Sarmiento, P.; Safer, J.; Coley, C. W.; Renard, B. Y.; Heyne, H. O.; Iqbal, S.
10.1101/2024.06.21.600139 — bioinformatics — Posted on 2025-02-11
3169 Methylomes reveal recent evolutionary changes in populations of two plant species
Korfmann, K.; Zauchner, A.; Huo, B.; Grünke, C.; Wang, Y.; Tellier, A.; Arunkumar, R.
10.1101/2024.09.30.615871 — evolutionary biology — Posted on 2025-02-11
3172 Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis
Groborz, K. M.; Truong, M. E.; Stowe, I.; Lee, B.; Jones, R. S.; Plise, E.; Levy, E. S.; Kou, P.; Lee, W. P.; Zhang, J.; Nguyen, J.; Kalinka, M.; Drag, M.; Kayagaki, N.; Newton, K.; Poreba, M.; Dixit, V.
10.1101/2025.02.11.637513 — cell biology — Posted on 2025-02-11
3173 Let-7 restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis
Seasock, M. J.; Shafiquzzaman, M.; Ruiz-Echartea, M. E.; Kanchi, R. S.; Tran, B. T.; Simon, L. M.; Meyer, M. D.; Erice, P. A.; Lotlikar, S. L.; Wenlock, S. C.; Ochsner, S. A.; Enright, A.; Carisey, A. F.; Romero, F.; Rosas, I. O.; King, K. Y.; McKenna, N. J.; Coarfa, C.; Rodriguez, A.
10.1101/2024.05.22.595205 — cell biology — Posted on 2025-02-11
3174 Cryo-EM analysis of the Bacillus thuringiensis extrasporal matrix identifies F-ENA as a widespread family of endospore appendages across the Firmicutes phylum
Sleutel, M.; Sogues, A.; Van Gerven, N.; Jonsmoen, U. L.; Van Molle, I.; Fislage, M.; Theunissen, L. D.; Bellis, N. F.; Baquero, D. P.; Egelman, E.; Krupovic, M.; Wang, F.; Aspholm, M. E.; Remaut, H.
10.1101/2025.02.11.637640 — molecular biology — Posted on 2025-02-11
3175 ReaxFF-guided Optimisation of VIRIP-based HIV-1 Entry Inhibitors
Zech, F.; Jung, C.; Alfonso, A. R.; Koehler, J.; Staendker, L.; Weidinger, G.; Jacob, T.; Kirchhoff, F.
10.1101/2025.02.11.637598 — molecular biology — Posted on 2025-02-11
3177 Genomic Insights into Ceftazidime Resistance in Burkholderia pseudomallei: Discovery of A172T Mutation, and Palindromic GC-Rich Repeat Sequences Facilitating penA Duplication and Amplification.
Tuanyok, A.; Nakajima, C.; Noll, T.; Khan, M. S.; Khrongsee, P.; Yowell, C. A.; Xiao, Y.-P.; Wuthiekanun, V.; Chantratita, N.; Heine, H.; Subramaniam, K.; Suzuki, Y.; Limmathurotsaku, D.; Mergia, A.
10.1101/2025.02.11.637714 — microbiology — Posted on 2025-02-11
3179 In harmony? A scoping review of methods to combine multiple 16S amplicon data sets
Li, Z.; Chen, Y.; Sun, Y.; McArthur, K.; Carnes, M. U.; Liu, T.; Mueller, N. T.; Page, G. P.; Rossman, L. M.; Smirnova, E.; White, J. D.; Kress, A. M.; Debelius, J. W.
10.1101/2025.02.11.637740 — microbiology — Posted on 2025-02-11
3181 Mutations in TAC1B drive CDR1 and MDR1 expression and azole resistance in C. auris
Barker, K. S.; Santana, D. J.; Zhang, Q.; Peters, T. L.; Rybak, J.; Morschhauser, J.; Cuomo, C. A.; Rogers, P. D.
10.1101/2025.02.11.637698 — microbiology — Posted on 2025-02-11
3183 Cethromycin Pharmacokinetics and Pharmacodynamics for Single Dose Cure of Plasmodium berghei Liver Stages
Kennedy, G. J.; West, R. M.; Poti, K.; Bobb, B.; Ippolito, M. M.; Marzinke, M. A.; Kaludov, N.; Sullivan, D. J.
10.1101/2025.02.10.637401 — microbiology — Posted on 2025-02-11
3188 Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection
Zhang, H.; Wang, Y.; Wang, Y.; Hou, H.; Wang, Y.; Deng, X.; Xu, Z.; Xia, X.; Xu, M.; Wang, Z.; Wang, Y.; Zhang, C.; Zhumanov, K.; Sheng, J.; Zhang, H.; Ma, Z.; Yi, J.; Chen, C.
10.1101/2025.02.10.637385 — microbiology — Posted on 2025-02-11
3189 Specificities of Chemosensory Receptors in the Human Gut Microbiota
Xu, W.; Jalomo-Khayrova, E.; Gumerov, V. M.; Ross, P. A.; Koebel, T. S.; Schindler, D.; Bange, G.; Jouline, I.; Sourjik, V.
10.1101/2025.02.11.637667 — microbiology — Posted on 2025-02-11
3190 A novel virus vB_PshM_Y4 with low similarity to both cultured and uncultured viruses
Zheng, Z.; Zhao, L.; Wang, W.; Liu, Y.; Zheng, K.; Chen, X.; Zhang, S.; Sun, Y.; Ma, Z.; Shao, H.; Sung, Y. Y.; Mok, W. J.; Wong, L. L.; Gao, C.; Sun, L.; Liang, Y. t.
10.1101/2025.02.10.637413 — microbiology — Posted on 2025-02-11
3192 Complex Human Hair Bearing Skin Organoids as Model for Herpes Simplex Virus 1 Infection in the Skin
Wyler, E.; Albertini, S.; Friedel, C. C.; Manukyan, A.; Huang, J.; Krasemann, S.; Plumbon, I.; Altmüller, J.; Conrad, T.; Radbruch, H.; Hafezi, W.; Hansen, A.; Grundhoff, A.; Landthaler, M.; Fischer, N.; Czech-Sioli, M.
10.1101/2025.02.10.637415 — microbiology — Posted on 2025-02-11
3195 Generalization but not strengthening of negative memories drives the development of depression-like behaviors
Cheng, X.; Hu, Y.; Zhao, Y.; Zhao, P.; Bai, X.; Chen, Y.; Kong, D.; Zheng, S.; Zheng, Y.; Wang, Y.; Zeng, Y.; Lin, W.-J.; Ye, X.
10.1101/2025.02.10.637591 — animal behavior and cognition — Posted on 2025-02-11
3197 Testosterone exposure during fetal masculinization programming window determines the kidney size in adult mice.
Junnila, A.; Rytkonen, K. T.; Martinez-Nieto, G.; Perk, M.; Li, H.; Airaksinen, J.; Hyotylainen, I.; Mehtovuori, O.; Laiho, A.; Ohlsson, C.; Elo, L. L.; Kuure, S.; Poutanen, M.; Sipila, P.
10.1101/2025.02.11.637631 — developmental biology — Posted on 2025-02-11
3198 Development of the zebrafish anterior lateral line system is influenced by underlying cranial neural crest
Venkataraman, V.; McGrory, N. H.; Christiansen, T. J.; Navajas Acedo, J.; Coates, M. I.; Prince, V. E.
10.1101/2025.02.11.637483 — developmental biology — Posted on 2025-02-11
3199 Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway
He, X.; Zhang, H.; Wang, Y.; Yan, H.; Chen, Q.; Su, M.; Shi, Q.; Zeng, X.; Sheng, W.; Wang, Y.; Wang, C.; Hou, S.; He, Y.; Wang, X.
10.1101/2025.02.11.637629 — developmental biology — Posted on 2025-02-11
3200 Systematic silencing of oncogenic fusion transcripts with ultra-precise CRISPR-Cas13b
Hu, W.; Chen, H.; Casan, J. M.; Shembrey, C.; He, S.; Brown, L. M.; Hughes, T. P.; White, D. L.; De Weck, A.; Voskoboinik, I.; Trapani, J. A.; Ekert, P. G.; Sadras, T.; Fareh, M.
10.1101/2025.02.10.637348 — molecular biology — Posted on 2025-02-11
3201 Decoding semantics from natural speech using human intracranial EEG
Pescatore, C. R. C.; Zhang, H.; Hadjinicolaou, A. E.; Paulk, A. C.; Rolston, J. D.; Richardson, R. M.; Williams, Z. M.; Cai, J.; Cash, S.
10.1101/2025.02.10.637051 — neuroscience — Posted on 2025-02-11
3204 A novel model of paclitaxel-induced peripheral neuropathy produces a clinically relevant phenotype in mice
Osborn, L. R.; Bishop, M. G.; Rodriguez, K. A.; Redling, D. M.; Duplechain, E. A.; Stephens, K. E.
10.1101/2025.02.10.637458 — neuroscience — Posted on 2025-02-11
3205 The signature of a T-cell response to KSHV persists across space and time in individuals with epidemic and endemic KS from Uganda
Ravishankar, S.; Towlerton, A. M. H.; Tiamiyu, I. L.; Mooka, P.; Nankoma, J.; Kafeero, J.; Mubiru, D.; Sekitene, S.; Aicher, L. D.; Miller, C. P.; Coffey, D. G.; Okoche, L.; Atwinirembabazi, P.; Okonye, J.; Koelle, D. M.; Jing, L.; Phipps, W. T.; Warren, E. H.
10.1101/2024.02.06.579223 — immunology — Posted on 2025-02-11
3206 Structural Development of Speech Networks in Young Children
Curtis, M.; Bayat, M.; Garic, D.; Alfano, A.; Hernandez, M.; Curzon, M.; Bejarano, A.; Tremblay, P.; Graziano, P.; Dick, A. S.
10.1101/2024.08.23.609470 — neuroscience — Posted on 2025-02-11
3208 Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Hanna, J.; Touahri, Y.; Pak, A.; Belfiore, L.; van Oosten, E.; David, L. A.; Han, S.; Ilnytskyy, Y.; Kovalchuk, I.; Kurrasch, D.; Okawa, S.; del Sol, A.; Screaton, R. A.; Aubert, I.; Schuurmans, C.
10.1101/2024.07.12.603298 — developmental biology — Posted on 2025-02-11
3209 Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts
Larrous, P.; Garnier, C.; Morel, M.; Martin, M. M.; Zarrouk, K.; Maesen, S.; Matkovic, R.; Cimarelli, A.; Etienne, L.; Margottin-Goguet, F.
10.1101/2024.03.07.583867 — microbiology — Posted on 2025-02-11
3211 Vitamin D promotes DNase1L3 to degrade ecDNA and inhibit the malignant progression of hepatocellular carcinoma
Zhang, H.; Qin, L.-n.; Li, Q.-q.; Wu, T.; Zhang, L.; Wang, K.-w.; Cheng, S.-b.; Shi, Y.; Feng, Y.-q.; Han, J.-x.; Li, Y.-n.; Li, Z.-y.; Liu, H.-j.; Sun, T.
10.1101/2023.08.30.555532 — cancer biology — Posted on 2025-02-11
3214 Unexpectedly low recombination rates and presence of hotspots in termite genomes
Everitt, T.; Ronneburg, T.; Elsner, D.; Olsson, A.; Liu, Y.; Larva, T.; Korb, J.; Webster, M. T.
10.1101/2024.03.22.586269 — genomics — Posted on 2025-02-11
3216 Divergent stem cell mechanisms governing the primary body axis and appendage regeneration in the axolotl
Wang, L.; Song, L.; Yi, C.; Zhou, J.; Yong, Z.; Hu, Y.; Pan, X.; Qiao, N.; Cai, H.; Zhao, W.; Zhang, R.; Yang, L.; Liu, L.; Peng, G.; Tanaka, E. M.; Li, H.; Liu, Y.; Fei, J.-F.
10.1101/2025.02.11.637618 — developmental biology — Posted on 2025-02-11
3217 Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife
Hou, X.; Wang, J.; Wang, D.-X.; Chen, Y.; Li, X.-X.; Wu, W.-C.; Le, S.-J.; Mei, S.-Q.; Liu, H.-L.; Feng, Y.; Yang, L.-F.; Shi, P.-B.; Ren, Z.-R.; Yang, L.; He, H.-J.; Song, W.-J.; Chen, J.; Zhu, M.-M.; Jiang, Z.-W.; Li, X.-M.; Li, M.-R.; Guo, D.; Holmes, E. C.; Deng, Z.-Q.; Shi, M.
10.1101/2025.01.09.632079 — microbiology — Posted on 2025-02-11
3219 Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland
de Freitas Almeida, G. M.; Arriaga, I.; de Azevedo, B. L.; Leppänen, M.; Abrahao, J. S.; Andreani, J.; Zabeo, D.; Ravantti, J. J.; Abrescia, N. G.; Sundberg, L.-R.
10.1101/2024.10.16.618641 — microbiology — Posted on 2025-02-11
3223 Thermal inactivation spectrum of influenza A H5N1 virus in raw milk
Nooruzzaman, M.; Covaleda, L.; Britto de Oliveira, P. S.; Martin, N. H.; Koebel, K. J.; Ivanek, R.; Alcaine, S. D.; Diel, D. G.
10.1101/2024.09.21.614205 — microbiology — Posted on 2025-02-11
3225 Patterns of Ongoing Thought in the Real World and Their Link to Mental Health and Well-Being
Mulholland, B.; Chitiz, L.; Wallace, R.; Mckeown, B.; Milham, M.; Klein, A.; Leech, R.; Jefferies, E.; Poerio, G.; Wammes, J.; Smallwood, J.; Stewart, J.
10.1101/2024.07.22.604681 — neuroscience — Posted on 2025-02-11
3228 A cluster of RNA Polymerase II molecules is stably associated with an active gene
Mukherjee, A.; Kapoor, M.; Shankta, K.; Fallacaro, S.; Carter, R. D.; Ratchasanmuang, P.; Haloush, Y. I.; Mir, M.
10.1101/2025.02.10.637507 — biophysics — Posted on 2025-02-11
3230 RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies
Hu, L.; Qiu, P.; Qin, H.; Cao, L.; Jiang, W.; Feng, B.; Zhang, Y.; Chen, Q.; Shang, Y.; Xia, T.; Deng, Z.; Xu, X.; Fang, S.; Li, Y.; Zhang, Y.
10.1101/2025.01.24.634217 — bioinformatics — Posted on 2025-02-11
3231 Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface
Mohanty, S. K.; Mittal, A.; Namra, ; Gaur, A.; Duari, S.; Solanki, S.; Sharma, A. K.; Arora, S.; Kumar, S.; Gautam, V.; Dixit, N. K.; Subramanian, K.; Ghosh, T. S.; Sengupta, D.; Gupta, S. K.; Murugan, N. A.; Sharma, D.; Ahuja, G.
10.1101/2023.02.14.528587 — bioinformatics — Posted on 2025-02-11
3232 MicroSplit: Semantic Unmixing of Fluorescent Microscopy Data
Ashesh, A.; Carrara, F.; Zubarev, I.; Galinova, V.; Croft, M.; Pezzotti, M.; Gong, D.; Casagrande, F.; Colombo, E.; Giussani, S.; Restelli, E.; Cammarota, E.; Battagliotti, J. M.; Klena, N.; Di Sante, M.; Pigino, G.; Taverna, E.; Harschnitz, O.; Maghelli, N.; Scherer, N. F.; Dalle Nogare, D. E.; Dechamps, J.; Pasqualini, F.; Jug, F.
10.1101/2025.02.10.637323 — bioinformatics — Posted on 2025-02-11
3237 Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation
Hogrebe, N. J.; Schmidt, M. D.; Augsornworawat, P.; Gale, S. E.; Shunkarova, M.; Millman, J. R.
10.1101/2024.10.21.618465 — cell biology — Posted on 2025-02-11
3241 Representation of locomotive action affordances in human behavior, brains and deep neural networks
Bartnik, C. G.; Sartzetaki, C.; Puigseslloses Sanchez, A.; Molenkamp, E.; Bommer, S.; Vuksic, N.; Groen, I. I. A.
10.1101/2024.05.15.594298 — neuroscience — Posted on 2025-02-11
3244 Noncanonical Short-Latency Auditory Pathway Directly Activates Deep Cortical Layers
Garcia, M. M.; Kline, A. M.; Onodera, K.; Tsukano, H.; Dandu, P. R.; Acosta, H. C.; Kasten, M.; Manis, P. B.; Kato, H. K.
10.1101/2025.01.06.631598 — neuroscience — Posted on 2025-02-11
3245 REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness
Mortazavi, N.; Talwar, P.; Koshmanova, E.; Sharifpour, R.; Beckers, E.; Berger, A.; Campbell, I.; Paparella, I.; Balda, F.; Dardour Hamzaoui, I.; Berthomier, C.; Bastin, C.; Phillips, C.; Maquet, P.; Collette, F.; Zubkov, M.; Lamalle, L.; Vandewalle, G.
10.1101/2024.07.12.603275 — neuroscience — Posted on 2025-02-11
3246 Resurrection of the Plant Immune Receptor Sr50 to Overcome Pathogen Immune Evasion
Seong, K.; Wei, W.; Sent, S. C.; Vega, B.; Dee, A.; Ramirez-Bernardino, G.; Kumar, R.; Parra, L.; Saur, I. M.; Krasileva, K.
10.1101/2024.08.07.607039 — plant biology — Posted on 2025-02-11
3248 Proteomics-based models of gene expression and cellular control of cotton fiber development
Lee, Y.; Yang, P.; Rani, H.; Miller, G.; Grover, C. E.; Swaminathan, S.; Zabotina, O. A.; Wendel, J. F.; Xie, J.; Szymanski, D. B.
10.1101/2025.02.05.636703 — plant biology — Posted on 2025-02-11
3250 Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy
Li, H.; Xie, Z.; Tian, Y.; Lin, B.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Chen, S.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.
10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-02-11
3253 Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude
Nong, J.; Gong, X.; Dang, Q. M.; Tiwari, S.; Patel, M.; Wu, J.; Hanna, A.; Park, W.-J.; Atochina-Vasserman, E. N.; Huang, H.-T.; Marcos-Contreras, O. A.; Morris-Blanco, K. C.; Miner, J. J.; Weissman, D.; Muzykantov, V. R.; Gupta, K.; Issadore, D.; Myerson, J. W.; Wang, Z.; Brenner, J. S.
10.1101/2024.11.12.623321 — bioengineering — Posted on 2025-02-11
3254 Molecular analyses of individual variation in honey bee sociability
Traniello, I. M.; Avalos, A.; Gachomba, M. J. M.; Gernat, T.; Chen, Z.; Cash-Ahmed, A. C.; Hamilton, A. R.; Cook, J. L.; Robinson, G. E.
10.1101/2024.12.22.629994 — genomics — Posted on 2025-02-11
3256 Cryptic recombination and transposition drive structural variation to shape genomic plasticity and life history traits in a host generalist fungal plant pathogen
Derbyshire, M. C.; Newman, T. E.; Khentry, Y.; Michael, P. J.; Bennett, S. J.; Rijal Lamichhane, A.; Graham-Taylor, C.; Chander, S.; Camplone, C.; Vicini, S.; Esquivel-Garcia, L.; Coutou, C.; Hegedus, D.; Clarkson, J.; Lindbeck, K.; Kamphuis, L. G.
10.1101/2024.07.02.600549 — genomics — Posted on 2025-02-11
3257 Engineering elephant models of cold-adaptation and cancer resistance
Karpinski, E.; Badey, N.; Mintzer, E.; Ashkenazy-Titelman, A.; Li, L.; Church, G. M.
10.1101/2024.09.07.611789 — genetics — Posted on 2025-02-11
3260 Drivers of plant-associated invertebrate community structure in West-European coastal dunes
Van De Walle, R.; Dahirel, M.; Langeraert, W.; Benoit, D.; Vantieghem, P.; Vandegehuchte, M. L.; Massol, F.; Bonte, D.
10.1101/2024.06.24.600350 — ecology — Posted on 2025-02-11
3262 Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis
Dady, A.; Davidson, L.; Loyer, N.; Rappich, S.; Findlay, G. M.; Sanders, T.; Januschke, J.; Storey, K. G.
10.1101/2024.05.01.591467 — developmental biology — Posted on 2025-02-11
3264 Altered dynamics of ATP synthase cause functional irregularities in senescent hiPS-cardiomyocytes
Morris, S.; Schmelter, F.; Molina Riquelme, I. E.; Peischard, S.; Disse, P.; Seebohm, G.; Eisner Sagues, V. R.; Busch, K. B.
10.1101/2024.06.04.597306 — cell biology — Posted on 2025-02-11
3265 Clostridioides difficile in Equidae necropsied in Normandie, France in 2019-2021: common carriage of toxigenic strains and virulence of emerging ribotype 017
Petry, S.; Tapprest, J.; Maillard, K.; Barbut, F.; DUQUESNE, F.; Kozak, S.; FOUCHER, N.; BERNEZ-ROMAND, M.; Bridoux, L.; Poquet, I.
10.1101/2024.09.30.615820 — microbiology — Posted on 2025-02-11
3266 Stable states in an unstable landscape: microbial resistance at the front line of climate change
Cronin, D. R.; Holland-Moritz, H.; Smith, D.; Aroney, S. T. N.; Hodgkins, S.; Borton, M.; Li, Y.-F.; Healy, K.; IsoGenie Field & Analytic Teams 2010-2017, ; EMERGE Institute Coordinators, ; Tfaily, M. M.; Crill, P. M.; McCalley, C.; Wrighton, K.; Varner, R. K.; Tyson, G. W.; Woodcroft, B.; Bagby, S. C.; Ernakovich, J.; Rich, V. I.
10.1101/2025.02.07.636677 — microbiology — Posted on 2025-02-11
3267 Conserved transcription factors coordinate synaptic gene expression through repression
Kentro, J. A.; Singh, G.; Pham, T. M.; Currie, J.; Khullar, S.; Medeiros, A. T.; Tsiarli, M. A.; Larschan, E.; O'Connor-Giles, K. M.
10.1101/2024.10.30.621128 — neuroscience — Posted on 2025-02-11
3269 Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition
Saenz de Miera, C.; Bellefontaine, N.; Silveira, M. A.; Fortin, C. N.; Zampieri, T. T.; Donato, J.; Williams, K. W.; Mendes-da-Silva, C.; Heikkinen, L.; Broberger, C.; Frazao, R.; Elias, C. F.
10.1101/2025.02.03.636271 — neuroscience — Posted on 2025-02-11
3270 Psilocybin as a Treatment for Repetitive Mild Head Injury: Evidence from Neuroradiology and Molecular Biology
Brengel, E. K.; Axe, B.; Maheswari, A.; Abeer, M. I.; Ortiz, R. J.; Woodward, T. J.; Walhof, R.; Utama, R.; Sawada, C.; Balaji, S.; Kulkarni, P. P.; Bradshaw, H. B.; Gitcho, M. A.; Ferris, C. F.
10.1101/2025.02.03.636248 — neuroscience — Posted on 2025-02-11
3271 Hippocampal ERK2 dimerization is critical for memory reconsolidation and synaptic plasticity
Ojea Ramos, S.; Medina, C.; Krwczyk, M. d. C.; Millan, J.; Acutain, M. F.; Romano, A.; Baez, M. V.; Urbano, F.; Boccia, M. M.; Feld, M.
10.1101/2024.09.06.611755 — neuroscience — Posted on 2025-02-11
3272 Binocular combination in the autonomic nervous system
Segala, F. G.; Bruno, A.; Martin, J. T.; Morsi, A. Y.; Wade, A. R.; Baker, D. H.
10.1101/2024.06.04.597314 — neuroscience — Posted on 2025-02-11
3274 Type-I nNOS neurons orchestrate cortical neural activity and vasomotion
Turner, K.; Brockway, D.; Hossain, M. S.; Griffith, K.; Greenawalt, D.; Zhang, Q.; Gheres, K.; Crowley, N.; Drew, P. J.
10.1101/2025.01.21.634042 — neuroscience — Posted on 2025-02-11
3277 Hi-C sequencing data from cortex laboratory rats
Kim, P.; Ward, R. R.; Sharp, B. M.; Williams, R. W.; Chen, H.
10.1101/2025.02.09.636698 — genomics — Posted on 2025-02-11
3281 Current and future relevance of marine spatial planning for the distribution of epibenthic invertebrate and fish species in a heavily used regional sea
Probst, W. N.; Rehren, J.; Kraan, C.; Haslob, H.; Neumann, H.; Lemmen, C.; Krishna, S.; Wirtz, K.; Stelzenmueller, V.
10.1101/2025.02.10.637456 — ecology — Posted on 2025-02-11
3282 A vertical stacking approach to rapid generation cycling for indoor growth of tall annual crops - the case of Vicia faba
Pazos Navarro, M.; Bennett, R. G.; Munday, C.; Creasy, R.; Catt, S. C.; Lichtenzveig, J.; Ribalta, F.; Croser, J.
10.1101/2025.02.09.637347 — plant biology — Posted on 2025-02-11
3286 In situ generated vaccine-like pyroptosome for personalized cancer immunotherapy
Chen, B.; Wan, F.; Xia, H.; Pan, X.; Wang, L.; Wang, Y.; Yan, Y.; Liu, J.; Tang, M.; Yang, Y.; Qin, M.; Ren, J.; Zhong, L.; Chen, W.; Zhang, Q.; Wang, Y.
10.1101/2025.02.09.636745 — cancer biology — Posted on 2025-02-11
3287 Collective Transitions from Orbiting to Matrix Invasion in 3D Multicellular Spheroids
Kim, J.; Jeong, H.; Falco, C.; Hruska, A. M.; Martinson, W. D.; Marzoratti, A.; Araiza, M.; Yang, H.; Franck, C.; Carrillo, J. A.; Guo, M.; Wong, I. Y.
10.1101/2025.02.10.636936 — biophysics — Posted on 2025-02-11
3290 CandyCollect Open to Closed (O2C) Microfluidic System for Rapid and User-Centric Detection of Group A Streptococcus
Leong, K. M.; Sanchez, J. C.; Craig, C.; Tatka, J. A.; Arvizu, R. R.; Robertson, I. H.; Shinkawa, V. A. M.; Robinson, T. R.; Chang, M. M.; Su, X.; Thongpang, S.; Theberge, A. B.; Berthier, E.; Olanrewaju, A. O.
10.1101/2025.02.10.635313 — bioengineering — Posted on 2025-02-11
3295 Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population
Michalopulos, M. G.; Liu, Y.; Raju, D. R.; Lafin, J. T.; Ma, Y.; Gaur, D.; Khadka, S.; Xing, C.; McMahon, A. P.; Carroll, T. J.; Drake, K. A.
10.1101/2025.02.10.637031 — developmental biology — Posted on 2025-02-11
3297 A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy
Arnese, R.; Dexheimer, P. J.; Escobar Doncel, B.; Krueger, L.; Adhikari, G.; Krpan, N.; Sehr, D.; Kley, J.; Deszcz, L.; Meinhart, A.; Kirstein, J.; Clausen, T.
10.1101/2025.02.10.636595 — cell biology — Posted on 2025-02-11
3298 Cohesin drives chromatin scanning during the RAD51-mediated homology search.
Marin-Gonzalez, A.; Rybczynski, A. T.; Nilavar, N. M.; Nguyen, D.; Karwacki- Neisius, V.; Li, A. G.; Zou, R. S.; Aviles-Vazquez, F. J.; Kanemaki, M. T.; Scully, R.; Ha, T.
10.1101/2025.02.10.637451 — cell biology — Posted on 2025-02-11
3301 Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork
Soundararajan, A.; Jaysankar, K.; Doud, E. H.; Pasteurin, R. P.; Surma, M.; Pattabiraman, P. P.
10.1101/2025.02.10.637394 — cell biology — Posted on 2025-02-11
3303 Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease
Tjaden, N. E. B.; Liou, M. J.; Sax, S.; Lassoued, N.; Lou, M.; Schneider, S.; Beigel, K.; Eisenberg, J. D.; Loeffler, E.; Anderson, S. E.; Yan, G.; Litichevskiy, L.; Dohnalova, L.; Zhu, Y.; Jin, D. M. J. C.; Raab, J.; Furth, E. E.; Thompson, Z.; Rubenstein, R. C.; Pilon, N.; Thaiss, C. A.; Heuckeroth, R.
10.1101/2025.02.10.637436 — cell biology — Posted on 2025-02-11
3304 Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion
Barke, N.; Masser, S.; Stalling, D.; Wyler, E.; Zinzen, R. P.; Schreiner, S.; Bosse, J.; Landthaler, M.
10.1101/2025.02.10.637450 — molecular biology — Posted on 2025-02-11
3306 Accelerated memory T cell decline and tolerogenic recall responses to SARS-CoV-2 vaccination in diabetes
Jones, E. M.; Sourij, C.; Stradner, M.; Schlenke, P.; Sereban, N.; Moser, O.; Quinlan, R.; Short, C.-E.; Harris, B. H. L.; Fertleman, M.; Taylor, G. P.; Oliver, N.; Sourij, H.; Dominguez-Villar, M.
10.1101/2025.02.08.637262 — immunology — Posted on 2025-02-11
3309 Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14
Wolfe, S. A.; Ma, Y.; Pilo, C. A.; Chang, C.; Ghassemian, M.; Roberts, A. J.; Lee, S. R.; Gorrie, G.; Taylor, S. S.; Newton, A. C.
10.1101/2025.02.10.637267 — neuroscience — Posted on 2025-02-11
3312 Neurons in the inferior colliculus use multiplexing to encode features of frequency-modulated sweeps
Drotos, A. C.; Wajdi, S. Z.; Malina, M.; Silveira, M. A.; Williamson, R. S.; Roberts, M. T.
10.1101/2025.02.10.637492 — neuroscience — Posted on 2025-02-11
3313 Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates
Choi, J.; Amjad, U.; Murray, R.; Shrivastav, R.; Teichert, T.; Goodell, B.; Schaeffer, D. J.; Oluoch, J. K.; Schwerdt, H. N.
10.1101/2025.02.10.636943 — neuroscience — Posted on 2025-02-11
3314 From ancient fears to airborne threats: fMRI insights into neural fear responses
Radlova, S.; Pidnebesna, A.; Chomik, A.; Tomecek, D.; Hlinka, J.; Frynta, D.; Landova, E.
10.1101/2025.02.10.636842 — neuroscience — Posted on 2025-02-11
3315 Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties
Solie, C.; Nicolson, A.; Justo, R.; Layadi, Y.; Morin, B.; Batifol, C.; Reynolds, L. M.; le Borgne, T.; Fayad, S. L.; Gulmez, A.; Allegret--vautrot, J.; De Chaumont, F.; Viollet, C.; Didienne, S.; Debray, N.; Hardelin, J.-P.; Girard, B.; Mourot, A.; Naude, J.; Fabio, M.; Delord, B.; Faure, P.
10.1101/2025.02.10.637303 — neuroscience — Posted on 2025-02-11
3316 Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD
Coneys, R.; Cammack, A. J.; Raghavan-Nair, R.; Thompson, D.; Mechtersheimer, J.; Carcole, M.; Gupta, Y.; Rech, G. E.; Flower, M.; O'Brien, N.; Ruepp, M.-D.; Mizielinska, S.; Ducotterd, F.; Tabrizi, S. J.; Fisher, E. M. C.; Cunningham, T. J.; Ward, M.; Skarnes, B.; Isaacs, A.
10.1101/2025.02.10.637041 — neuroscience — Posted on 2025-02-11
3317 Temporal dose inversion properties of adaptive biomolecular circuits
Nakamura, E.; Blanchini, F.; Giordano, G.; Hoffmann, A.; Franco, E.
10.1101/2025.02.10.636967 — systems biology — Posted on 2025-02-11
3322 17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats
Holter, K. M.; Klausner, M.; Hite, M. H.; Moriarty, C.; Barth, S.; Pierce, B.; Iannucci, A.; Sheffler, D.; Cosford, N.; Bimonte-Nelson, H.; Raab-Graham, K. F.; Gould, R. W.
10.1101/2025.02.10.637465 — animal behavior and cognition — Posted on 2025-02-11
3323 Remodeling of extracellular matrix collagen IV by MIG-6/papilin regulates neuronal architecture
Nadour, M.; LEATIS, R. I. V. R.; BIARD, M.; FREBAULT, N.; RIVOLLET, L.; St-Louis, P.; Blanchette, C. R.; Thackeray, A.; PERRAT, P.; BEVILACQUA, C.; PREVEDEL, R.; CAPPADOCIA, L.; Rapti, G.; Doitsidou, M.; Benard, C. Y.
10.1101/2025.02.10.637428 — developmental biology — Posted on 2025-02-10
3324 Molecularly-guided spatial proteomics captures single-cell identity and heterogeneity of the nervous system
Dutta, S.; Pang, M.; Coughlin, G. M.; Gudavalli, S.; Roukes, M. L.; Chou, T.-F.; Gradinaru, V.
10.1101/2025.02.10.637505 — neuroscience — Posted on 2025-02-11
3327 Impact of perinatal maternal docosahexaenoic acid-containing phospholipid synthesis on offspring growth and neurological symptoms
Kanatani, A.; Hishikawa, D.; Nagata, K.; Hamano, F.; Nakano, K.; Okamura, T.; Shimizu, T.; Shindou, H.; Nagamatsu, T.; Yanagida, K.
10.1101/2024.01.06.574487 — biochemistry — Posted on 2025-02-10
3328 Genomic and morphological characterization of Trichuris incognita, a Human-Infecting Trichuris species
Baer, M. A.; Kouame, N. A.; Toure, S.; Coulibaly, J. T.; Schneeberger, P. H. H.; Keiser, J.
10.1101/2024.06.11.598441 — genomics — Posted on 2025-02-10
3329 Cell-death induced immune response and coagulopathy promote cachexia in Drosophila
Singh, A.; Hu, Y.; Lopes, R. F.; Lane, L.; Woldemichael, H.; Xu, C.; Udeshi, N.; Carr, S. A.; Perrimon, N.
10.1101/2025.01.07.631515 — genetics — Posted on 2025-02-10
3332 Intentionally vs. Spontaneously Prolonged Gaze: A MEG Study of Active Gaze-Based Interaction
Vasilyev, A. N.; Svirin, E. P.; Dubynin, I. A.; Butorina, A. V.; Nuzhdin, Y. O.; Ossadtchi, A. E.; Stroganova, T. A.; Shishkin, S. L.
10.1101/2024.12.11.627776 — neuroscience — Posted on 2025-02-10
3334 Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes
Butler, M. L. M. D.; Pervaiz, N.; Breen, K.; Calderazzo, S.; Ypsilantis, P.; Wang, Y.; Breda, J. C.; Mazzilli, S. A.; Nicks, R.; Spurlock, E.; Hefti, M. M.; Fiock, K. L.; Huber, B. R.; Alvarez, V. E.; Stein, T. D.; Campbell, J. D.; McKee, A. C.; Cherry, J. D.
10.1101/2024.03.26.586815 — neuroscience — Posted on 2025-02-10
3336 Striatal and cerebellar interactions during reward-based motor performance
Lee, J. L.; Casamento-Moran, A.; Bastian, A. J.; Cullen, K. E.; Chib, V. S.
10.1101/2025.02.06.636434 — neuroscience — Posted on 2025-02-10
3346 Tap into non-symbiotic carbon? Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants
Chen, H.; Xiong, T.; Guan, B.; Huang, J.-q.; Zhao, D.; Chen, Y.; Liang, H.; Li, Y.; Wu, J.; Ye, S.; Li, T.; Shu, W.; Li, J.-t.; Wang, Y.
10.1101/2024.04.26.591230 — ecology — Posted on 2025-02-10
3350 YAbS: The Antibody Society's antibody therapeutics database
Rawat, P.; Crescioli, S.; Ramakrishnan, P.; Sharma, D.; Greiff, V.; Reichert, J.
10.1101/2025.02.07.637087 — scientific communication and education — Posted on 2025-02-10
3351 TAC-C uncovers open chromatin interaction in crops and SPL-mediated photosynthesis regulation
Kang, J.; Zhang, Z.; Lin, X.; Liu, F.; Song, Y.; Zhao, P.; Lin, Y.; Luo, X.; Li, X.; Li, Y.; Wang, W.; Liu, C.; Xu, S.; Liu, X.; Xiao, J.
10.1101/2025.02.10.637364 — plant biology — Posted on 2025-02-10
3352 Two cowpea Rubisco activase isoforms for crop thermotolerance
Gjindali, A.; Page, R.; Ashton, C. J.; Robertson, I.; Page, M. T.; Bloemers, D.; Gould, P. D.; Worrall, D.; Orr, D. J.; Carmo-Silva, E.
10.1101/2025.01.31.635870 — plant biology — Posted on 2025-02-10
3354 Unraveling diversity by isolating peptide sequences specific to distinct taxonomic groups
Bochalis, E.; Patsakis, M.; Chantzi, N.; Mouratidis, I.; Chartoumpekis, D.; Georgakopoulos-Soares, I.
10.1101/2025.02.05.636664 — bioinformatics — Posted on 2025-02-10
3356 ERGA-BGE genome of Pinctada radiata (Leach, 1814): one of the first Lessepsian migrants
Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Sequencing Team, G.; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Istace, B.; Couloux, A.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Haggerty, L.; Martin, F.; Bortoluzzi, C.
10.1101/2025.01.17.632165 — genomics — Posted on 2025-02-10
3357 Whole genome sequencing reveals how plasticity and genetic differentiation underlie sympatric morphs of Arctic charr
Kurta, K.; Olivera Fedi, M.; Baker, K.; Barker, T.; Catchpole, L.; Ciofi, C.; Cocco, A.; Diedericks, G.; Diroma, M. A.; Hindar, K.; Lannucci, A.; Irish, N.; Knitlhoffer, V.; Laikre, L.; Leitao, H. G.; Lucchini, S.; McTaggart, S.; Palsson, A.; Pettersson, M. E.; Ryman, N.; Snorrason, S. S.; Svardal, H.; Swarbreck, D.; Waterhouse, R. M.; Watkins, C.; Xiao, H. H.; Gharbi, K.; Jonsson, Z. O.; Andersson, L.
10.1101/2025.02.10.637319 — evolutionary biology — Posted on 2025-02-10
3359 Lydicamycins Induce Morphological Differentiation in Actinobacterial Interactions
Jarmusch, S. A.; Schostag, M. D.; Yang, Z.; Wang, J.; Andersen, A. J. C.; Weber, T.; Ding, L.
10.1101/2024.06.28.600750 — microbiology — Posted on 2025-02-10
3360 High-resolution temporal profiling of the gut microbiome through the whole life of mice
Takayasu, L.; Watanabe, E.; Umeyama, T.; Kurokawa, R.; Maskawa, R.; Basu, S.; Ogata, Y.; Kiguchi, Y.; Masuoka, H.; Umezaki, M.; Takayasu, H.; Takayasu, M.; Hattori, M.; Suda, W.
10.1101/2022.11.07.515511 — microbiology — Posted on 2025-02-10
3362 Pre- and postnatal maternal depressive symptoms associate with local connectivity of the left amygdala in 5-year-olds
Vartiainen, E.; Copeland, A.; Pulli, E. P.; Kumpulainen, V.; Silver, E.; Rajasilta, O.; Jolly, A.; Luotonen, S.; Audah, H. K.; Hashempour, N.; Bano, W.; Suuronen, I.; Saukko, E.; Hakkinen, S.; Karlsson, H.; Karlsson, L.; Tuulari, J. J.
10.1101/2024.06.21.600007 — neuroscience — Posted on 2025-02-10
3364 Early neural responses to nonconscious fearful and neutral faces - an ERP study
Bruchmann, M.; Schindler, S.; Breitwieser, P.; Tilly, L.; Boelte, J.; Dellert, T.; Straube, T.
10.1101/2025.01.30.635452 — neuroscience — Posted on 2025-02-10
3366 The Landscape of Prostate Tumour Methylation
Arbet, J.; Shiah, Y.-J.; Yamaguchi, T. N.; Hugh-White, R.; Wiggins, A.; Oh, J.; Gebo, T.; Foucal, A.; Lesurf, R.; Jung, C.-H.; Dang, R. M. A.; Agrawal, R.; Livingstone, J.; Salcedo, A.; Yao, C. Q.; Espiritu, S. M. G.; Houlahan, K. E.; Yousif, F.; Heisler, L. E.; Fraser, M.; Kishan, A.; Berlin, A.; Chua, M. L.; van der Kwast, T.; Hovens, C. M.; Bristow, R. G.; Boutros, P. C.
10.1101/2025.02.07.637178 — cancer biology — Posted on 2025-02-10
3367 Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcome
Pereira, G. P.; Lins, M. P.; Fontoura, J.; Osvaldt, A. B.; Machado, S. M. d. S.; Filippi-Chiela, E. C.; Bonorino, C.
10.1101/2025.02.08.637283 — cancer biology — Posted on 2025-02-10
3370 CV.eDNA: A hybrid approach to invertebrate biomonitoring using computer vision and DNA metabarcoding
Blair, J. D.; Weiser, M. D.; Siler, C. D.; Kaspari, M.; Smith, S. N.; McLaughlin, J. F.; Marshall, K. E.
10.1101/2024.09.02.610558 — bioinformatics — Posted on 2025-02-10
3371 Protein language models accelerate the discovery of Plastic-Degrading Enzymes
Medina-Ortiz, D.; Alvarez-Saravia, D.; Soto-Garcia, N.; Sandoval-Vargas, D.; Aldridge, J.; Rodriguez, S.; Andrews, B.; Asenjo, J. A.; Daza, A.
10.1101/2025.02.09.637306 — bioengineering — Posted on 2025-02-10
3375 Intrinsic immunity against HAdV is achieved by a novel epigenetic silencing complex
Mai, J.; Karimi, M.; Kuderna, A. K.; Heider, A.; Guenther, T.; Friedel, C.; Grundhoff, A.; Stamminger, T.; Schreiner, S.
10.1101/2025.02.10.637372 — cell biology — Posted on 2025-02-10
3377 Identification of new interactors of eIF3f by endogenous proximity-dependent biotin labelling in human muscle cells.
Tintignac, L.; Mittal, N.; Alam, S.; Ataman, M.; Ertuna, Y. I.; Bock, T.; Erne, B.; Zavolan, M.; Sinnreich, M.
10.1101/2025.02.10.636994 — molecular biology — Posted on 2025-02-10
3378 Viral infection impacts volatile organic compound production in the coccolithophore Gephyrocapsa huxleyi
Buchholz, H. H.; Mojica, K. D. A.; Comstock, J.; Collart, L.; Giovannoni, S. J.; Halsey, K. H.
10.1101/2025.02.09.637333 — microbiology — Posted on 2025-02-10
3379 Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature
Hehl, M.; Scherer, M.; Raubuch, E.-M.; Ploil, C.; Rummel, T.; Kirchner, P.; Kottmann, N.; Reichel, A.; Kuderna, A. K.; Koenig, A.-C.; Friedel, C. C.; Erhard, F.; Stamminger, T.
10.1101/2025.02.10.637376 — microbiology — Posted on 2025-02-10
3380 Candida albicans: a comprehensive view of the proteome
Gomez Artiguez, L.; de la Camara Fuentes, S.; Sun, Z.; Hernaez-Sanchez, M. L.; Borrajo, A.; Pitarch, A.; Molero, G.; Monteoliva Diaz, L.; Moritz, R. L.; Deutsch, E. W.; Gil, C.
10.1101/2024.12.20.629377 — microbiology — Posted on 2025-02-10
3382 Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy
Drago, D.; Giri, S.; Chattaerjee, R.; Simoni Nieves, A.; Abedrabbo, M.; Genna, A.; Uribe Rios, M. L.; Lindzen, M.; Sekar, A.; Gupta, N.; Aharoni, N.; Bhandari, T.; Mayalagu, A.; Schwarzmuller, L.; Tarade, N.; Zhu, R.; Mohan-Raju, H.-R.; Karatekin, F.; Roncato, F.; Eyal-Lubling, Y.; Keidar, T.; Nof, Y.; Belugali Nataraj, N.; Bernshtein, K. S.; Wagner, B.; Ulhas Nair, N.; Sanghvi, N.; Alon, R.; Seger, R.; Pikarsky, E.; Donzelli, S.; Blandino, G.; Wiemann, S.; Lev, S.; Prywes, R.; Barkan, D.; Rueda, O.; Caldas, C.; Ruppin, E.; Shiloh, Y.; Dahlhoff, M.; Yarden, Y.
10.1101/2025.02.09.636592 — cancer biology — Posted on 2025-02-10
3383 Interplay between cytokine and FGF2 signaling in induction of entosis and vasculogenic mimicry response in glioblastoma
Kang, T.-Y.; Park, J.; Dincer, A.; Baskaran, J.; Ren, C.; Scuderi, S.; Yang, L.; McGuone, D.; Miller-Jensen, K.; Gunel, J. M.; Gunel, M.; Levchenko, A.
10.1101/2025.02.09.637275 — cancer biology — Posted on 2025-02-10
3387 ZSeeker: An optimized algorithm for Z-DNA detection in genomic sequences
Wang, G.; Mouratidis, I.; Provatas, K.; Chantzi, N.; Georgakopoulos-Soares, I.; Vasquez, K. M.
10.1101/2025.02.07.637205 — bioinformatics — Posted on 2025-02-10
3388 Tracing social mechanisms and interregional connections in Early Bronze Age Societies in Lower Austria
Furtwaengler, A.; Rebay-Salisbury, K.; Neumann, G. U.; Kanz, F.; Ringbauer, H.; Bianco, R. A.; Schmidt, T.; Semerau, L.; Radzeviciute, R.; Barquera, R.; Rohland, N.; Stewardson, K.; Workman, J. N.; Curtis, E.; Zalzala, F.; Callan, K.; Iliev, L.; Qiu, L.; cheronet, O.; Wagner, A.; Bravo Morante, G.; Teschler-Nicola, M.; Spannagl-Steiner, U. M.; Novotny, F.; Verdianu, D.; Pinhasi, R.; Reich, D. E.; Krause, J.; Stockhammer, P.; Mittnik, A.
10.1101/2025.02.10.636471 — genetics — Posted on 2025-02-10
3389 Proximity determines donor candidacy during DNA double-stranded break homology directed repair
Yeh, C. D.; van de Venn, L.; Kreutzer, S.; Zheng, X.; Cantos, N.; Schroeder, M.; Hofmann, R.; Gerbaldo, F. E.; Clemens, A.; Wienert, B.; Richardson, C. D.; Kontarakis, Z.; Corn, J. E.
10.1101/2025.02.10.637161 — molecular biology — Posted on 2025-02-10
3391 Glycosylphosphatidylinositol biosynthesis restricts coronavirus infection via the regulation of LY6E
Ma, Y.; Feng, F.; Feng, H.; Ma, X.; Wang, Z.; Han, Y.; Zhu, Y.; Wang, Y.; Gao, Z.; Zhang, Y.; Zhao, J.; Zhang, R.
10.1101/2025.02.08.637211 — microbiology — Posted on 2025-02-10
3393 IFNγ regulates MR1 transcription and antigen presentation
Huber, M. E.; Larson, E. A.; Lust, T. N.; Heisler, C. M.; Harriff, M. J.
10.1101/2025.02.09.637183 — immunology — Posted on 2025-02-10
3397 Calcium channel-coupled transcription factors facilitate direct nuclear signaling
Rao, E. R.; Thaxton, T.; Gama, E.; Godfrey, J.; Wei, C.; Lin, Q.; Li, Y.; Pastor, D. P. H.; Hansel, C.; Du, X.; Gomez, C. M.
10.1101/2025.02.09.637126 — neuroscience — Posted on 2025-02-10
3398 3-D Reconstruction of Fingertip Deformation during Contact Initiation
Doumont, D.; Kao, A. R.; Lambert, J.; Wielant, F.; Gerling, G. J.; Delhaye, B. P.; Lefevre, P.
10.1101/2025.02.10.637366 — neuroscience — Posted on 2025-02-10
3400 Self-supervised image restoration in coherent X-rayneuronal microscopy
Laugros, A.; Cloetens, P.; Bosch, C.; Schoonhoven, R.; Pavlovic, L.; Kuan, A. T.; Livingstone, J.; Zhang, Y.; Hendriksen, A.; Holler, M.; Wanner, A. A.; Azevedo, A.; Batenburg, K. J.; Tuthill, J. C.; Lee, W.-C. A.; Schaefer, A. T.; Vigano, N.; Pacureanu, A.
10.1101/2025.02.10.633538 — neuroscience — Posted on 2025-02-10
3404 Brain bases for navigating acoustic features
Billig, A. J.; Sedley, W.; Gander, P. E.; Kumar, S.; Lad, M. J.; Chait, M.; Mohammadi, Y.; Berger, J. I.; Griffiths, T.
10.1101/2025.02.10.636597 — neuroscience — Posted on 2025-02-10
3405 Offset analgesia and onset hyperalgesia: A comparison between women with non-suicidal self-injury and healthy women
Fust, J.; Kastrati, G.; Bjureberg, J.; Jayaram-Lindström, N.; Hellner, C.; Kosek, E.; Fransson, P.; Jensen, K. B.; Lalouni, M.
10.1101/2025.02.07.637056 — neuroscience — Posted on 2025-02-10
3406 Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors
Chen, J.; Zhu, M.; Peng, J.; Wang, M.; Lin, S.; Zhou, Y.; Dai, X.; Zhao, H.; Zhang, H.; Yu, Y.-Q.; Shen, L.; Li, X.-M.
10.1101/2025.02.10.637400 — neuroscience — Posted on 2025-02-10
3409 A lateralized pathway for associating nutrients with flavors
Grove, J. C. R.; Li, Q.; Backes, H.; Kuzmanovic, B.; Choi, J.; Ubadiah, V.; Qiu, L.; Zhang, J.; Liu, Z.; Small, D. M.; Tittgemeyer, M.; Knight, Z. A.
10.1101/2025.02.09.637334 — neuroscience — Posted on 2025-02-10
3410 The sensorimotor basis of subjective experience in social synchronization behavior
Bremer, J. P.; Knorr, M. S.; Goeschl, F.; Maye, A.; Engel, A. K.; Schneider, T. R.
10.1101/2025.02.09.637302 — neuroscience — Posted on 2025-02-10
3411 Functional connectivity of thalamic nuclei during sensorimotor task-based fMRI at 9.4 Tesla
Charyasz, E.; Erb, M.; Bause, J.; Heule, R.; Bender, B.; Kumar, V. J.; Grodd, W.; Scheffler, K.
10.1101/2025.02.09.632791 — neuroscience — Posted on 2025-02-10
3412 Non-invasive peripheral delivery of CDNF fragment protects neurons in models of Parkinsons and ALS
Yu, L.; Viljakainen, T.; Beckett, L.; Nam, J.; Hyysalo, A.; Luningschror, P.; Albert, K.; Koppinen, T. K.; Hyvarinen, T.; Tossavainen, H.; Hellman, M.; Airavaara, M.; Sendtner, M.; Permi, P.; Lindholm, P.; Saarma, M.; Voutilainen, M. H.
10.1101/2025.02.09.637291 — neuroscience — Posted on 2025-02-10
3414 Stable Actin As Synaptic Tag
Thomas, M.; Bogaciu, C.-A.; Rizzoli, S.; Fauth, M.
10.1101/2025.02.10.637360 — neuroscience — Posted on 2025-02-10
3415 Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling
Thomazeau, A.; Rannio, S.; Brock, J. A.; Wong, H. H.-W.; Sjöström, P. J.
10.1101/2025.02.07.637179 — neuroscience — Posted on 2025-02-10
3416 A haplotype-resolved reference genome for Eucalyptus grandis
Lötter, A.; Bruna, T.; Duong, T. A.; Barry, K.; Lipzen, A.; Daum, C.; Yoshinaga, Y.; Grimwood, J.; Jenkins, J. J.; Talag, J.; Borevitz, J. O.; Lovell, J. T.; Schmutz, J.; Wegrzyn, J. L.; Myburg, A.
10.1101/2025.02.07.637144 — genomics — Posted on 2025-02-10
3417 WISER: an innovative and efficient method for correcting population structure in omics-based selection and association studies
Jacquin, L. J.; Guerra, W.; Lewandowski, M.; Patocchi, A.; Rymenants, M.; Durel, C.-E.; Laurens, F.; Aranzana, M. J.; Muranty, H.
10.1101/2025.02.07.637171 — genetics — Posted on 2025-02-10
3420 Soil and water microbial communities: A source of novel antibiotics for sustainable plant disease control
Iqbal, N.; Asim, N.; Malik, S.; Khan, S.; Yoo, Y.; Akbar, S.; Ullah, I.; Liu, L.; Khan, S. S.; lee, S. w.
10.1101/2025.02.06.636970 — microbiology — Posted on 2025-02-10
3421 Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis
Ejby, M.; Sakanaka, M.; Jensen, M.; Koguchi Sakanaka, H.; Pichler, M. J.; Maeda, S.; Franck Hovring, J.; Nakajima, A.; Kunstmann, S.; Nielsen, T. S.; Peters, G. H. J.; Slotboom, D. J.; Morth, J. P.; Katayama, T.; Abou Hachem, M.
10.1101/2025.02.07.637197 — microbiology — Posted on 2025-02-10
3424 A perturbation proteomics-based foundation model for virtual cell construction
Sun, R.; qian, l.; Li, Y.; Cheng, H.; Xue, Z.; zhang, x.; Tan, L.; Zhan, Y.; hu, w.; Xiao, Q.; Liu, Z.; zhang, g.; E, W.; Zhou, P.; Wen, H.; Zhu, Y. J.; Guo, T.
10.1101/2025.02.07.637070 — systems biology — Posted on 2025-02-10
3427 Cohesin guides homology search during DNA repairvia loops and sister chromatid linkages
Teloni, F.; Takacs, Z.; Mitter, M.; Langer, C. C. H.; Prlesi, I.; Steinacker, T. L.; Reuter, V. P.; Mylarshchikov, D.; Gerlich, D. W.
10.1101/2025.02.10.637359 — cell biology — Posted on 2025-02-10
3428 Phosphorylated CheV interacts with a subset of chemoreceptors
Matilla, M. A.; Cano-Munoz, M.; Monteagudo-Cascales, E.; Krell, T.
10.1101/2025.02.06.636884 — microbiology — Posted on 2025-02-10
3429 Immune responses to human pathogens exposed to simulated Mars conditions
Zaccaria, T.; Bulut, O.; Ferreira, A.; Dona, M.; Langereis, J. D.; Mesman, R. J.; Wesseling, J.; van Niftrik, L.; Netea, M.; Rettberg, P.; Beblo-Vranesevic, K.; de Jonge, M. I.; Dominguez-Andres, J.
10.1101/2025.02.05.636683 — immunology — Posted on 2025-02-10
3431 Dynamic fMRI networks of emotion
Janssen, N.; Elvira, U. K. A.; Janssen, J.; van Erp, T.
10.1101/2025.02.05.636581 — neuroscience — Posted on 2025-02-10
3433 Onlinemeta: A Web Server for Meta-Analysis Based on Shiny Framework
Dai, W.; Yi, Y.; Lin, A.; Zhou, C.; Zhang, J.; Wang, S.; Sun, M.; Luo, P.
10.1101/2022.04.13.488126 — bioinformatics — Posted on 2025-02-10
3436 Towards an unbiased characterization of genetic polymorphism
Igolkina, A.; Vorbrugg, S.; Rabanal, F.; Liu, H.-J.; Ashkenazy, H.; Kornienko, A.; Fitz, J.; Collenberg, M.; Kubica, C.; Morales, A. M.; Jaegle, B.; Wrightsman, T.; Voloshin, V.; Llaca, V.; Nizhynska, V.; Reichardt, I.; Lanz, C.; Bemm, F.; Flood, P. J.; Nemomissa, S.; Hancock, A.; Guo, Y.-L.; Kersey, P.; Weigel, D.; Nordborg, M.
10.1101/2024.05.30.596703 — genomics — Posted on 2025-02-10
3437 Development of ferret immune repertoire reference resources and single-cell-based high-throughput profiling assays
Walsh, E. S.; Yang, K.; Tollison, T. S.; Seenu, S.; Adams, N.; Zeitoun, G.; Sideri, I.; Folch, G.; Brochu, H.; Chou, H.; Kossida, S.; York, I. A.; Peng, X.
10.1101/2025.02.05.636682 — genomics — Posted on 2025-02-10
3438 Evidence for evolution of a new sex chromosome within the Marchantiales haploid-dominant plant lineage
Fu, Y.; Zhang, X.; Zhang, T.; Sun, W.; Yang, W.; Shi, Y.; Zhang, J.; He, Q.; Charlesworth, D.; Jiao, Y.; Chen, Z.; Xu, B.
10.1101/2025.01.16.633329 — evolutionary biology — Posted on 2025-02-10
3440 Melanoma cells suppress mast cell growth via a melanin-dependent mechanism
Pejler, G.; Rabelo Melo, F.; Nyman, L.; Osterman Menander, I.; Grijic, M.
10.1101/2025.02.03.636204 — immunology — Posted on 2025-02-10
3441 Immuno-Responsive Gene-1: The Mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity
Nematullah, M.; Fatma, M.; Zhou, G.; Rashid, F.; Ayasolla, K.; Ahmed, M. E.; Sajad, M.; Zahoor, I.; Hoda, N.; Rattan, R.; Giri, s.
10.1101/2023.12.24.573264 — immunology — Posted on 2025-02-10
3442 Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis
Durham, L. E.; Humby, F.; Ng, N.; Gray, E. H.; Ryan, S. E.; Ross, R.; Povoleri, G. A. M.; Nuamah, R.; Fung, K.; Kallayil, A. M.; Dhami, P.; Kirkham, B. W.; Taams, L. S.
10.1101/2024.05.09.593313 — immunology — Posted on 2025-02-10
3443 A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity
Boggess, S. C.; Gandhi, V.; Tsai, M.-C.; Marzette, E.; Teyssier, N.; Chou, J. Y.-Y.; Hu, X.; Cramer, A.; Yadanar, L.; Shroff, K.; Jeong, C. G.; Eidenschenk, C.; Hanson, J. E.; Tian, R.; Kampmann, M.
10.1101/2024.02.28.582546 — neuroscience — Posted on 2025-02-10
3445 Neural mechanisms of flexible perceptual inference
Schwarcz, J.; Bauer, J.; Rajabi, H.; Marmur, G.; Lottem, E.; Kadmon, J.
10.1101/2025.02.05.636696 — neuroscience — Posted on 2025-02-10
3448 Cancer cells suppress NK activity by actin-driven polarisation of inhibitory ligands at the synapse
Hoffmann, C.; Filali, L.; Wurzer, H.; Pereira Fernandes, D.; Mgrditchian, T.; Moreau, F.; Krecke, M.; Thomas, C.
10.1101/2025.02.03.636217 — cancer biology — Posted on 2025-02-10
3452 Mismatch repair and homologous recombination are yin-yang partners in hybrid zygote meiosis
Chuang, C.-N.; Hung, Y.-L.; Kim, H.-X.; Yao, J.-S.; Liu, H.-C.; Chen, S.-Y.; Jovanska, L.; Hsueh, Y.-P.; Chen, R.-S.; Wang, T.-F.
10.1101/2025.02.08.636946 — genetics — Posted on 2025-02-10
3453 Replication-Deficient Whole-Virus Vaccines Against Cytomegalovirus Induce Protective Immunity in a Guinea Pig Congenital Infection Model
Schleiss, M. R.; Fernandez-Alarcon, C.; Bierle, C. J.; Geballe, A. P.; Badillo-Guzman, A. J.; Tanna, C. E.; Tsriwong, K.; Blackstad, M.; Wang, J. B.; McVoy, M. A.
10.1101/2025.02.04.636391 — immunology — Posted on 2025-02-10
3454 Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants
Fishman, M. R.; Greigenhagen, A.; Wakatake, T.; Laohavisit, A.; Hiroyama, R.; Masuda, S.; Shibata, A.; Yoshida, S.; Shirasu, K.
10.1101/2025.02.09.637280 — plant biology — Posted on 2025-02-10
3456 Linking acoustic telemetry data to spatial covariates in river networks with spatially explicit capture-recapture models
Bottoms, J. R.; Auger-Methe, M.; O'Connor, B.; Power, M.; Patterson, D. A.; Shrimpton, J. M.; Cooke, S. J.; Martins, E.
10.1101/2025.02.09.637304 — ecology — Posted on 2025-02-10
3457 Macroinvertebrate diversity patterns in a guano-rich temperate cave
Dainelli, L.; Martinez, A.; Serena, F.; Gammuto, L.; Graco-Roza, C.; Langeneck, J.; Mammola, S.; Petroni, G.
10.1101/2025.02.09.637321 — ecology — Posted on 2025-02-10
3458 Wildlife trade drives animal-to-human pathogen transmission over 40 years
Gippet, J. M. W.; Carlson, C. J.; Klaftenberger, T.; Schweizer, M.; Bertelsmeier, C.
10.1101/2025.02.09.637309 — ecology — Posted on 2025-02-10
3460 Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue
Mesentier-Louro, L. A.; Goldman, C.; Ndayisaba, A.; Buonfiglioli, A.; Rooklin, R. B.; Schuldt, B. R.; Uchitelev, A.; Khurana, V.; Blanchard, J. W.
10.1101/2025.02.09.637107 — neuroscience — Posted on 2025-02-09
3463 Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation
Zhong, Q.; Chen, D.; Xu, J.; Li, Y.; Meng, Y.; Wen, Q.; Ye, Q.; Wang, G.; Pan, K.; Tao, L.; Qiao, J.; Hang, J.
10.1101/2025.02.09.637231 — biochemistry — Posted on 2025-02-09
3464 Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations
Agyapong, N.; Dominguez-Ortega, L.; Macdonough, B.; Mulluso, P.; Patel, S.; Prajapati, B.; Saville, B.; Shapiro, A.; Trim, E.; Battaglia, K.; Herrera, J.; Garifo-MacPartland, G.; Newcomb, D.; Okundaye, L.; Paglia, H.; Paxson, J.
10.1101/2025.02.08.637273 — developmental biology — Posted on 2025-02-09
3466 Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency
Zhu, Y.; Kleinpeter, A.; Lancheros, J. S. R.; Shen, J.; Shen, Y.; Xu, J.; Hardenbrook, N.; Chen, L.; Lucic, A.; Perilla, J. R.; Freed, E. O.; zhang, p.
10.1101/2025.02.09.637297 — microbiology — Posted on 2025-02-09
3467 Clinical isolates of Enterobacter species can persist in human macrophages without bacterial replication and minimal cellular cytotoxicity
Parau, G.; Parks, H.; Anderson, A.; Bisaro, F.; Romero, I. G.; Gilmore, M.; Korankye, S.; Marshall, H.; Valvano, M.
10.1101/2025.02.08.637254 — microbiology — Posted on 2025-02-09
3468 Cross-membrane cooperation among bacteria can facilitate intracellular pathogenesis
Schator, D.; Kumar, N. G.; Chong, S. J. U.; Jung, T. K.; Jedel, E.; Smith, B.; Evans, D. J.; Fleiszig, S. M. J.
10.1101/2025.02.09.637186 — microbiology — Posted on 2025-02-09
3470 A Semi-Automated MEA Spike sorting (SAMS) method for high throughput assessment of cultured neurons
Ren, X.; Sirois, C. L.; Doudlah, R.; Mendez-Albelo, N. M.; Hai, A.; Rosenberg, A.; Zhao, X.
10.1101/2025.02.08.637245 — neuroscience — Posted on 2025-02-09
3473 Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease
Liu, C.; Okada, L.; Gillespie, M. A.; Genge, P.; Weiss, M.; Hernandez, V.; Reading, J.; Becker, L.; Bumol, T. F.; Skene, P.; Deane, K. D.; Feser, M. L.; Demouruelle, M. K.; Kuhn, K. A.; Holers, V. M.; Zhang, F.; Moss, L. K.; Criley, M.; Hattel, B.; Siedschlag, M.; Prideaux, E. B.; Wu, P.; Boyle, D. L.; Westermann, A.; Nguyen, K.; Tsaltskan, V.; Lazaro, L.; Ochoa, A.; Buckner, J. H.; Speake, C.; Firestein, G. S.; Wang, W.
10.1101/2025.02.08.619913 — systems biology — Posted on 2025-02-09
3478 A ternary switch determines ERα LBD conformation
McDougal, D. P.; Pederick, J. L.; Novick, S.; Jovcevski, B.; Warrender, A. K.; Pascal, B. D.; Griffin, P. R.; Bruning, J. B.
10.1101/2025.02.09.637324 — biochemistry — Posted on 2025-02-09
3480 Enhanced Computational and Experimental Approaches for Comparative Analysis of the Human Mycobiome
Begum, N.; Shoaie, S.; Moyes, D. L.; Lee, S.; Almeida, M.; Engstrand, L.; Patel, V. C.; Uhlen, M.; Ehrlich, D.
10.1101/2025.02.09.637295 — genomics — Posted on 2025-02-09
3482 Wastewater metaproteomics: tracking microbial and human protein biomarkers
Tugui, C. G.; Cordesius, F.; van Holthe, W.; van Loosdrecht, M. C. M.; Pabst, M.
10.1101/2025.02.08.637285 — ecology — Posted on 2025-02-09
3484 Exploiting the SunTag system to study the developmental regulation of mRNA translation
Pizzey, A.; Sutcliffe, C.; Love, J. C.; Akabuogu, E.; Rattray, M.; Ashe, M. P.; Ashe, H.
10.1101/2025.02.09.637317 — developmental biology — Posted on 2025-02-09
3485 EndoMAPV1, a Structural Protein Complex Landscape of Human Endosomes
Gonzalez-Lozano, M.; Schmid, E. W.; Whelan, E. M.; Jiang, Y.; Paulo, J. A.; Walter, J.; Harper, J. W.
10.1101/2025.02.07.636106 — cell biology — Posted on 2025-02-09
3486 Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease
Barve, A.; Cornwell, A.; Sriram, P.; Kopyov, A.; Dabas, P.; Kooienga, E.; Kelley, Z.; Johnson, J.; Myers, J.; Obeng, E.; Kang, G.; Olufadi, Y.; Cain, T.; Talbot, L.; Spence, D.; Cortes, M.; Miller, S.; Loeffler, D.; Sharma, A.; McKinney-Freeman, S.
10.1101/2025.02.08.636742 — cell biology — Posted on 2025-02-09
3487 Multi-Omics Analysis of Wound Microbiome and Staphylococcus aureus in Pressure Ulcer
Guo, C.; Jiang, G.; Li, Y.; Zhao, J.; Ji, L.; Li, S.; Li, H.; Zhou, Z.; Xie, E.
10.1101/2025.02.08.637207 — microbiology — Posted on 2025-02-09
3490 Infectome Analysis of Small Mammals in Southern China Reveals Ecological Associations and Emerging Threats from Diverse Pathogens
xin, g.; Wang, D.; Zhang, X.; Cen, Q.; Peng, M.; Liao, Y.; Wang, J.; Le, S.; Cheng, J.; Wu, W.; Hou, X.; Luo, G.; Gou, Q.; Kong, J.; Pan, Z.; Li, D.; Gan, S.; Chen, A.; Zhao, H.; Shi, P.; Ren, Z.; Zhao, W.; Liu, J.; Jia, P.; Sun, C.; Lin, W.; Wu, J.; Kuang, G.; Chen, J.; LI, J.; Holmes, E. C.; Deng, Z.; Shi, M.
10.1101/2025.02.09.637073 — microbiology — Posted on 2025-02-09
3492 Amygdala GABA Neurons: Gatekeepers of Stress and Reproduction
Yu, J.; Farjami, S.; Nechyporenko, K.; Li, X. F.; Yaseen, H.; Lin, Y.; Ye, J.; Hollings, O.; de Burgh, R.; O'Byrne, K. T.; Tsaneva-Atanasova, K.; Voliotis, M.
10.1101/2025.01.06.631361 — physiology — Posted on 2025-02-09
3493 Conditional Dystrophin ablation in the skeletal muscle and brain causes profound effects on muscle function, neurobehavior, and extracellular matrix pathways
Karuppasamy, M.; English, K. G.; Conner, J. R.; Rorrer, S. N.; Lopez, M. A.; Crossman, D. K.; Paul, J. R.; Monreal-Gutierrez, M. A.; Gamble, K. L.; Esser, K. A.; Widrick, J. J.; Kunkel, L. M.; Alexander, M. S.
10.1101/2025.01.30.635777 — genetics — Posted on 2025-02-09
3495 Proliferative cell targeting and epithelial cell turnover fuels hepatitis E virus replication in human intestinal enteroids
Santos-Ferreira, N.; Zhang, X.; Corneillie, L.; Van Dycke, J.; Chiu, W.; Montpellier, C.; Neyts, J.; Cocquerel, L.; Kaptein, S.; Rocha-Pereira, J.
10.1101/2024.03.27.586953 — microbiology — Posted on 2025-02-09
3496 DprA recruits ComM to facilitate recombination during natural transformation in Gram-negative bacteria
Dalia, T. N.; Machouri, M.; Lacrouts, C.; Fauconnet, Y.; Guerois, R.; Andreani, J.; Radicella, J. P.; Dalia, A. B.
10.1101/2024.10.21.619469 — microbiology — Posted on 2025-02-09
3498 Testing the Vogt-Bailey Index using task-based fMRI across pulse sequence protocols
Galea, K.; Escudero, A. A.; Attard-Montalto, N.; Vella, N.; Smith, R. E.; Farrugia, C.; Galdi, P.; Scerri, K.; Butler, L.; Bajada, C. J.
10.1101/2025.02.06.636866 — neuroscience — Posted on 2025-02-09
3500 Establishment of an optimized and automated workflow for whole brain probing of neuronal activity.
CABRERA, S.; VACHOUD, N.; BREUILLY, M.; DESMERCIERES, S.; MACIEL, R. M.; MEYER-DILHET, G.; ELLOUZE, S.; COURCHET, J.; LUPPI, P.-H.; MANDAIRON, N.; RAINETEAU, O.
10.1101/2024.09.16.611953 — neuroscience — Posted on 2025-02-09
3504 AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications
Galindo, G.; Maejima, D.; DeRoo, J.; Burlingham, S.; Fixen, G.; Morisaki, T.; Febvre, H.; Hasbrook, R.; Zhao, N.; Ghosh, S.; Mayton, E. H.; Snow, C.; Geiss, B. J.; Ohkawa, Y.; Sato, Y.; Kimura, H.; Stasevich, T. J.
10.1101/2025.02.06.636921 — cell biology — Posted on 2025-02-09
3507 Complementary MR measures of white matter and their relation to cardiovascular health and cognition
Raykov, P. P.; Correia, M. M.; Tsvetanov, K. A.; Henriques, R. N.; del Cerro Leon, A.; Bracher-Smith, M.; Escott-Price, V.; Raykov, Y. P.; Henson, R. N.
10.1101/2025.02.08.637219 — neuroscience — Posted on 2025-02-08
3509 A genetically-diverse mouse model reveals a complex gene-environment regulation of cognitive resilience and susceptibility to Alzheimer disease
Dunn, A. R.; Kaur, H.; Dai, Y.; Charland, K.; Ouellette, A. R.; Hadad, N.; Doyle, P. H.; Acosta, G. H. G.; Litkowski, E. M.; Hohman, T. J.; O'Connell, K. M. S.; Kaczorowski, C. C.
10.1101/2025.02.07.637137 — neuroscience — Posted on 2025-02-08
3510 An integrative model of AMPA receptor trafficking reveals the central contribution of local translation in subtype-specific kinetics
Wagle, S.; Kracht, M. K.; Bührke, A.; Acker-Palmer, A.; Kraynyukova, N.; Hafner, A.-S.; Schuman, E. M.; Tchumatchenko, T.
10.1101/2025.02.08.637220 — neuroscience — Posted on 2025-02-08
3512 Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers
Mukhopadhyay, A.; Chanakul, W.; Larpin, Y.-N.; Awasthi, S.; Protopopova, A. D.; Köffel, R.; Ianiro, A.; Mayer, M.
10.1101/2025.02.07.637128 — biophysics — Posted on 2025-02-08
3516 Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles
Hofbauer, S. I.; Fink, L.; Young, R. E.; Vijayakumar, T.; Nelson, K.; Bellopeded, N.; Alameh, M.-G.; Weissman, D. E.; Gleghorn, J. P.; Riley, R. S.
10.1101/2025.02.07.637086 — bioengineering — Posted on 2025-02-08
3517 Towards a tracking of bird migratory behaviour through geological time: an isotopic and histological approach
Duhamel, A.; Canoville, A.; Vincon-Laugier, A.; Joseph, J.; Fourel, F.; Lecuyer, C.; Amiot, R.; Louchart, A.
10.1101/2025.02.08.637244 — evolutionary biology — Posted on 2025-02-08
3518 Community-level plant functional strategies explain ecosystem carbon storage across a tropical elevational gradient
Mauki, D. G.; Mauki, D. G.; Mauki, D. G.; Manning, P.; Manning, P.; Schleuning, M.; Hemp, A.; Schellenberger Costa, D.; Schellenberger Costa, D.; Sierra Cornejo, N.; Becker, J.; Becker, J.; Ensslin, A.; Rutten, G.; Neyret, M.
10.1101/2025.02.08.637226 — ecology — Posted on 2025-02-08
3520 Mycobacterial infection uncovers plasticity of Kupffer cells
Neuber, J.; Lohrmann, F.; Wald, S.; Goecer, M.; Loesslein, A. K.; Obwegs, D.; Gres, V.; Goldmann, T.; Rogg, M.; Schell, C.; Preissl, S.; Sagar, S.; Henneke, P.
10.1101/2025.02.07.636999 — immunology — Posted on 2025-02-08
3521 Computation-through-Dynamics Benchmark: Simulated datasets and quality metrics for dynamical models of neural activity
Versteeg, C.; McCart, J. D.; Ostrow, M.; Zoltowski, D. M.; Washington, C. B.; Driscoll, L.; Codol, O.; Michaels, J. A.; Linderman, S. W.; Sussillo, D.; Pandarinath, C.
10.1101/2025.02.07.637062 — neuroscience — Posted on 2025-02-08
3522 Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis
Bryan, M. R.; Almeida, M.; Opland, C.; McGillion-Moore, J.; Trzeciakiewicz, H.; King, D.; Tian, X.; Tseng, J.-H.; Schisler, J.; Bahr, B.; Cohen, T. J.
10.1101/2025.02.07.636933 — neuroscience — Posted on 2025-02-08
3525 DMT-induced shifts in criticality correlate with ego-dissolution
Irrmischer, M.; Aqil, M.; Luan, L.; Wang, T.; Engelbregt, H.; Carhart-Harris, R.; Linkenkaer-Hansen, K.; Timmermann, C.
10.1101/2025.02.08.636868 — neuroscience — Posted on 2025-02-08
3526 Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice
Greer, R.; Verdier, A.; Butt, E.; Cheng, Y.; Callas, E.; McAlinden, N.; Dawson, M. D.; Bathellier, B.; Mathieson, K.
10.1101/2025.02.08.637222 — neuroscience — Posted on 2025-02-08
3527 Cocaine extended access gates compulsive-like seeking in rats
Tapia-Pacheco, M.; de Peretti, J.-L.; Vignal, L.; Williams, M.; BAUNEZ, C.; Goaillard, J.-M.; Degoulet, M.
10.1101/2025.02.07.637011 — neuroscience — Posted on 2025-02-08
3529 Motion processing in visual cortex of maculopathy patients
Michaud, C.; Guenot, J.; Faurite, C.; Gallice, M.; Chiquet, C.; Vayssiere, N.; Berry, I.; Trotter, Y.; Soler, V.; Peyrin, C.; Cottereau, B. R.
10.1101/2025.02.07.636620 — neuroscience — Posted on 2025-02-08
3530 Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner
Tomas-Gracia, M.; Mauro, A. K.; Duffy, C. K.; Dai, E. Y.; Shahab, G.; Medina, C. B.; Ravichandran, K. S.; Isakson, B. E.; Good, M. E.
10.1101/2025.02.07.636909 — physiology — Posted on 2025-02-08
3531 Seven blood biomarkers are associated with TGF-β and VHL-HIF signaling in patients with clear cell renal cell carcinoma
Mallikarjuna, P.; Erdem, C.; Hedman, H.; Sitaram, R. T.; Beorlegui, R. I.; Aripaka, K.; Larsson, A.; Ljungberg, B.; Kamali-Moghaddam, M.; Landstrom, M.
10.1101/2025.02.07.636864 — cancer biology — Posted on 2025-02-08
3533 Pancreatic cancer-intrinsic HuR regulates the pro-tumorigenic properties of extracellular vesicles
Finan, J. M.; Guo, Y.; Bartlett, A. Q.; Reyer, M.; Hawthorne, K.; Haerr, M.; Halamish, H.; Lamikanra, O.; Calvert, V.; Chen, C.; Xia, Z.; Petricoin, E. F.; Sears, R. C.; Byrne, K. T.; Brody, J. R.
10.1101/2025.02.08.637077 — cancer biology — Posted on 2025-02-08
3534 A kinetic model of antigen-dependent IgG oligomerization and complement binding
Strasser, J.; Frischauf, N.; Schustereder, L.; Karner, A.; Bosgra, S.; Labrijn, A. F.; Beurskens, F. J.; Preiner, J.
10.1101/2025.02.04.635266 — biophysics — Posted on 2025-02-08
3536 Cell signaling pathways discovery from multi-modal data
He, C.; Simpson, C.; Cossentino, I.; Zhang, B.; Tkachev, S.; Eddins, D. J.; Kosters, A.; Yang, J.; Sheth, S.; Levy, T.; Possemato, A.; Huang, L.; Tabatsky, E.; Gregoretti, I.; Ariss, M.; Dandekar, D.; Ausekar, A.; Ghosn, E. E. B.; Colonna, M.; Rikova, K.; Nie, Q.; Orlova, D.
10.1101/2025.02.06.636961 — bioinformatics — Posted on 2025-02-08
3538 Genome Sequence of a Marine Threespine Stickleback (Gasterosteus aculeatus) from Rabbit Slough in the Cook Inlet
Au, E. H.; Weaver, S.; Katikaneni, A.; Wucherpfennig, J. I.; Luo, Y.; Mangan, R. J.; Wund, M. A.; Bell, M. A.; Lowe, C. B.
10.1101/2025.02.06.636934 — genomics — Posted on 2025-02-08
3539 Commercial Saccharomyces cerevisiae baker's yeasts: strain redundancy, genome plasticity, and colonization of the sourdough environment and the human body
Racz, H. V.; Imre, A.; Nemeth, B.; Antunovics, Z.; Bazenova, R.; Bendixsen, D.; Harmath, A.; Herman, L.; Fulep, A.; Lopandic, K.; Mathe, E.; Poliska, S.; Pocsi, I.; Stelkens, R.; Pfliegler, W. P.
10.1101/2025.02.07.637159 — microbiology — Posted on 2025-02-08
3541 Xylazine potentiates the interoceptive effects of fentanyl in male and female rats
Bender, B. N.; Carew, J. M.; Bedard, M. L.; McElligott, Z. A.; Besheer, J.
10.1101/2025.02.07.637099 — neuroscience — Posted on 2025-02-08
3542 Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington's Disease mice
Blumenstock, S.; Arakelyan, D.; del Grosso, N.; Schneider, S.; Shao, Y.; Gjoni, E.; Klein, R.; Dudanova, I.; Komiyama, T.
10.1101/2025.02.07.637155 — neuroscience — Posted on 2025-02-08
3546 Differences Among Fungal Microbiomes Associated with Tar Spot of Corn in Ecuador, Guatemala, and Indiana, USA
Sic-Hernandez, W. R.; Gribskov, M.; Acosta, A. G.; Cruz, A.; Zambrano, J. L.; Racancoj Coyoy, A. J.; Cruz, C. D.; Goodwin, S. B.
10.1101/2025.02.07.637150 — plant biology — Posted on 2025-02-08
3547 SHINE: Deterministic Many-to-Many clustering of Molecular Pathways
Chen, L.; Leung, J.; Zsigmond, K.; Chong, L.; Miranda Quintana, R. A.
10.1101/2025.02.07.636541 — biophysics — Posted on 2025-02-08
3554 Direct Optical Detection of Factor Xa Activity in Minimally Processed Whole Blood
Cartwright, A. P.; Wollant, B. C.; York, E. S.; Zheng, L.; Yee, S.; Chau, H. C.; Batsuli, G.; Soh, H. T.
10.1101/2025.02.07.636760 — bioengineering — Posted on 2025-02-08
3558 Powerful and accurate case-control analysis of spatial molecular data with deep learning-defined tissue microniches
Reshef, Y.; Sood, L.; Curtis, M.; Rumker, L.; Stein, D.; Palshikar, M. G.; Nayar, S.; Filer, A.; Jonsson, A. H.; Korsunsky, I.; Raychaudhuri, S. J.
10.1101/2025.02.07.637149 — genomics — Posted on 2025-02-08
3559 De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement
O'Geen, H.; Mihalovits, A.; Brophy, B. D.; Yang, H.; Miller, M. W.; Lee, C. J.; Segal, D. J.; Tomkova, M.
10.1101/2025.02.07.636872 — genomics — Posted on 2025-02-08
3561 Somatic mutations distinguish melanocyte subpopulations in human skin
Tandukar, B.; Deivendran, D.; Chen, L.; Bahrani, N.; Weier, B.; Sharma, H.; Cruz-Pacheco, N.; Hu, M.; Marks, K.; Zitnay, R. G.; Bandari, A. K.; Nekoonam, R.; Yeh, I.; Judson-Torres, R.; Shain, A. H.
10.1101/2025.02.07.637114 — cell biology — Posted on 2025-02-08
3563 Impact of Soil Salinity on Microbial Community Composition in Coastal Agricultural lands of Bangladesh: A Metagenomic Approach
Das, S.; Nayem, M. R.; Hira, K. N.; Shermin, R.; Hosen, M. R.; Hossain, M. A.; Tariquzzaman, M.; Biswas, R.; Rahman, F. A.; Saha, M. K.; Rabbi, M. F. A.
10.1101/2025.02.08.637242 — microbiology — Posted on 2025-02-08
3566 Coupling chromosome organization to genome segregation in Archaea
Kabli, A. F.; Ng, I. W.; Read, N.; Pal, P.; Reimann, J.; Tran, N. T.; Albers, S.-V.; Le, T. B. K.; Barilla, D.
10.1101/2025.02.07.637068 — microbiology — Posted on 2025-02-08
3567 Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi
Sze, C. W.; Lynch, M. J.; Zhang, K.; Neau, D. B.; Ealick, S. E.; CRANE, B. R.; Li, C.
10.1101/2025.02.07.637162 — microbiology — Posted on 2025-02-08
3568 Construction of a low-temperature degrading synthetic bacterial community of corn straw
Fang, Y.; Li, J.; Zhang, W.; Ye, x.; Zhu, X. Z.; Xie, Y.; Feng, Y.; Yu, Y.; Yu, S.; Zhang, L.; Zou, H.
10.1101/2025.02.07.637170 — microbiology — Posted on 2025-02-08
3570 Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome.
PFEIFER, E.; Humieres, C.; Lamy-Besnier, Q.; Plaza-Onate, F.; Denise, R.; Dion, S.; Condamine, B.; Touchon, M.; Ma, L.; Burdet, C.; Mentre, F.; Denamur, E.; Rocha, E.
10.1101/2025.02.07.636470 — microbiology — Posted on 2025-02-08
3572 Early-life infection with Cryptosporidium parvum induces inflammatory responses to dietary antigens
Saraav, I.; Huang, W.; Jung, J.; Xu, R.; Fu, Y.; McDonald, K. G.; Schriefer, L. A.; Rogers, R.; Baldridge, M. T.; Newberry, R. D.; Hsieh, C.-S.; Sibley, L. D.
10.1101/2025.02.07.637163 — microbiology — Posted on 2025-02-08
3573 Human colon stem cells are the principal epithelial responders to bacterial antigens
de Vries, M. H.; Meddens, C.; Hijma, H.; Berrens, A.-C.; Jansen, S.; Kooiman, B.; Snapper, S.; Clevers, H.; Mokry, M.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.02.07.637053 — immunology — Posted on 2025-02-08
3574 Anti- and Pro-tumor Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer
Huang, X.; Feng, D.; Mitra, S.; Andretta, E. S.; Hooshdaran, N. B.; Ghelani, A. p.; Wang, E. Y.; Frost, J. N.; Lawless, V. R.; Vancheswaran, A.; Jiang, Q.; Leslie, C. S.; Rudensky, A.
10.1101/2025.02.07.637083 — immunology — Posted on 2025-02-08
3577 From imaging to computational domains for physics-driven molecular biology simulations: Hindered diffusion in platelet masses
House, C.; Huang, Z.; Shankar, K. N.; Young, S. J.; Roberts, M. E.; Diamond, S. L.; Tomaiuolo, M.; Stalker, T. J.; Lu, L.; Sinno, T.
10.1101/2025.02.06.636817 — systems biology — Posted on 2025-02-08
3578 Metabolomics characterisation of cassava pre-breeding populations with enhanced whitefly tolerance
Perez-Fons, L.; Bohorquez, A.; Gomez Jimenez, M. I.; Becerra Lopez-Lavalle, L. A.; Fraser, P. D.
10.1101/2025.02.05.636665 — plant biology — Posted on 2025-02-08
3579 Production of HPV-16 L1 virus-like particles in Physcomitrella photobioreactors
Niederau, P. A.; Weilguny, M. C.; Chamas, S.; Turney, C. E.; Parsons, J.; Rodriguez-Franco, M.; Hoernstein, S. N. W.; Decker, E. L.; Toft Simonsen, H.; Reski, R.
10.1101/2025.02.06.636855 — plant biology — Posted on 2025-02-08
3582 Defining the limits of differential transpiration
Sinha, R.; Pelaez-Vico, M. A.; Fritschi, F. B.; Mittler, R.
10.1101/2025.02.07.637037 — plant biology — Posted on 2025-02-08
3583 Enabling the Study of Gene Function in Gymnosperms: VIGS in Ephedra tweedieana
Garcia, A. G.; Bui, J. T.; Michael, T. P.; Ickert-Bond, S. M.; Di Stilio, V. S.
10.1101/2025.02.07.637168 — plant biology — Posted on 2025-02-08
3584 SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection
De Neck, S.; Penrice-Randal, R.; Hetzel, U.; Seehusen, F.; Sharma, P.; Bentley, E. G.; Helminger, B.; Kirby, A.; Balistreri, G.; Stewart, J. P.; Kipar, A.
10.1101/2025.02.07.637145 — pathology — Posted on 2025-02-08
3585 Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma
Crawford, K. J.; Humphrey, K. S.; Cortes, E.; Wang, J.; Feigin, M. E.; Witkiewicz, A. K.; Knudsen, E. S.; Abel, E. V.
10.1101/2025.02.06.636643 — cancer biology — Posted on 2025-02-08
3586 Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma
Anichini, A.; Caruso, F. P.; Lagano, V.; Noviello, T. M. R.; Tufano, R.; Nicolini, G.; Molla, A.; Bersani, I.; Sgambelluri, F.; Covre, A.; Lofiego, M. F.; Coral, S.; Di Giacomo, A. M.; Simonetti, E.; Valeri, B.; Cossa, M.; Ugolini, F.; Simi, S.; Massi, D.; Milione, M.; Maurichi, A.; Patuzzo, R. I.; Santinami, M.; Maio, M.; Ceccarelli, M.; Mortarini, R.
10.1101/2025.02.07.637045 — cancer biology — Posted on 2025-02-08
3587 Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production
Huggler, K. S.; Mellado Fritz, C. A.; Flickinger, K. M.; Chang, G. R.; McGuire, M. F.; Cantor, J. R.
10.1101/2025.02.07.637120 — cancer biology — Posted on 2025-02-08
3588 siRNA-based Therapeutic Candidate Targeting PRDM2 for Inhibition of Lung Cancer Progression
Kumar, S.; Malik, M. Z.; Chaturvedi, M.; Mishra, M.; Donato, M. D.; Casamassimi, A.; Abbondanza, C.; Gazzerro, P.; Nguyen, C.; Nunez, N. N.; Sen, S.; Niles, B.; Chaturvedi, R.
10.1101/2025.02.06.636957 — cancer biology — Posted on 2025-02-08
3589 CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance
Buj, R.; Cole, A. R.; Danielson, J.; Xu, J.; Hurd, D.; Kishore, A.; Kedziora, K. M.; Chen, J.; Yang, B.; Barras, D.; Uboveja, A.; Amalric, A.; Apiz, J. J.; Wickramasinghe, J.; Tangudu, N. K.; Levasseur, E.; Wang, H.; Minasyan, A.; Dadey, R. E.; Sharrow, A. C.; Vendetti, F. P.; Rivadeneira, D. B.; Bakkenist, C. J.; Delgoffe, G. M.; Hempel, N.; Snyder, N. W.; Bao, R.; Soloff, A. C.; Kirkwood, J. M.; Dangaj Laniti, D.; Kossenkov, A. V.; Muir, A.; Das, J.; Davar, D.; Mesaros, C.; Aird, K. M.
10.1101/2025.02.08.637227 — cancer biology — Posted on 2025-02-08
3590 Angstrom-resolution imaging of cell-surface glycans
Masullo, L.; Almahayni, K.; Pachmayr, I.; Honsa, M.; Heinze, L.; Fritsche, S.; Grabmayr, H.; Jungmann, R.; Moeckl, L.
10.1101/2025.02.07.637003 — biophysics — Posted on 2025-02-08
3591 Magnetic activation of electrically active cells
Duret, G.; Coffler, S.; Avants, B.; Kim, W.; Peterchev, A. V.; Robinson, J. T.
10.1101/2025.02.07.636926 — biophysics — Posted on 2025-02-08
3595 IQI: Individualized Quantitative trait loci (QTL) Index
Xu, J.; Sun, C.; Tao, J.; Wei, S.; Dong, Y.; Guo, X.; Tian, H.; Chen, H.; Ma, Y.; Lyu, W.; Bi, S.; Zou, Y.; She, W.; Zhang, C.; Kang, J.; Kong, F.; Zhang, M.; Lyu, H.; Jiang, Y.
10.1101/2025.02.06.636780 — bioinformatics — Posted on 2025-02-08
3598 The fluid genomic organisation of jingmenviruses
Valle, C.; Parry, R. H.; Coutard, B.; Colmant, A. M. G.
10.1101/2025.02.07.637040 — bioinformatics — Posted on 2025-02-08
3599 Pangenome graph augmentation from unassembled long reads
Denti, L.; Bonizzoni, P.; Brejova, B.; Chikhi, R.; Krannich, T.; Vinar, T.; Hormozdiari, F.
10.1101/2025.02.07.637057 — bioinformatics — Posted on 2025-02-08
3608 Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6
Skinner, K. A.; Fisher, T. D.; Lee, A.; Su, T.; Forte, E.; Sanchez, A.; Caldwell, M. A.; Kelleher, N. L.
10.1101/2025.02.07.637157 — biochemistry — Posted on 2025-02-08
3609 High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations
O'Brien, T. J.; Navarro, E. P.; Barroso, C.; Menzies, L.; Martinez-Perez, E.; Carling, D.; Brown, A. E. X.
10.1101/2025.02.07.637026 — animal behavior and cognition — Posted on 2025-02-08
3610 Distinguishing new from persistent infections at the strain level using longitudinal genotyping data
Nickols, W. A.; Schwabl, P.; Niangaly, A.; Murphy, S. C.; Crompton, P. D.; Neafsey, D. E.
10.1101/2025.02.06.636982 — genomics — Posted on 2025-02-08
3615 Massively parallel assessment of gene regulatory activity at human cortical structure associated variants
Matoba, N.; McAffee, J. C.; Krupa, O.; Bell, J.; Le, B. D.; Valone, J. M.; Crawford, G. E.; Won, H.; Stein, J. L.
10.1101/2025.02.08.635393 — genetics — Posted on 2025-02-08
3616 In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease
Ibel, A.; Bhardwaj, R.; Yilmaz, D. E.; Kong, S.; Wendlinger, S.; Papaioannou, D.; Diezemann, C.; Eckardt, K.-U.; Hasan, F.; Klaembt, V.; Halbritter, J.; Fedeles, S.; Krappitz, M.; Kaminski, M. M.
10.1101/2025.02.07.636600 — genetics — Posted on 2025-02-08
3618 Butterflies Are Shrinking: Evidence from the Past Century
Zografou, K.; Knop, E.; Sewall, B. J.; Adamidis, G. C.; Schweiger, O.; Semertzidis, T.; Stalidis, P.; De Moraes, C. M.; Mescher, M. C.; Whitaker, M. R.; Greeff, M.; Anagnostellis, K. M.; Brokaki, M.; Kaltsouni, E.; Dimaki, M.; Kati, V.
10.1101/2025.02.05.636603 — ecology — Posted on 2025-02-08
3619 Rot or not? Uncovering the spatial patterns and drivers of Norway spruce root rot with harvester data
Suvanto, S.; Heikkinen, J.; Holmstrom, E.; Honkaniemi, J.; Piri, T.; Hantula, J.; Rasanen, T.; Riekki, K.; Sorsa, J.-A.; Hytonen, H.; Hoglund, H.; Rajala, T.; Lehtonen, A.; Peltoniemi, M.
10.1101/2025.02.07.637055 — ecology — Posted on 2025-02-08
3620 Use of massive DNA barcoding to monitor biodiversity: a test on forest soil fauna
Jabot, F.; Auger, G. B.; Bonnal, P.; Pizaine, M.; Roncoroni, M.; Revaillot, S.; Pottier, J.
10.1101/2025.02.07.636998 — ecology — Posted on 2025-02-08
3621 Butterfly body size shrinkage: the impact of ecological traits across varied environments
Zografou, K.; Knop, E.; Sewall, B. J.; Schweiger, O.; De Moraes, C. M.; Whitaker, M. R.; Kati, V.
10.1101/2025.02.06.636804 — ecology — Posted on 2025-02-08
3624 Genomic insights reveal community structure and phylogenetic associations of endohyphal bacteria and viruses in fungal endophytes
Escudero Leyva, E.; Belle, M.; DadkhahTehrani, A.; Culver, J. N.; Araya Salas, M.; Kutza, J. P.; Goldson, N.; Chavarria, M.; Chaverri, P.
10.1101/2025.02.07.637084 — ecology — Posted on 2025-02-08
3627 Cross-Species Biomechanical Determinants of Shape Diversity
Bailleul, R.; Cuny, N.; Khoromoskaia, D.; Basu, S.; Bergamini, G.; Cucurachi, P.; Rupp, S.; Guse, A.; Curantz, C.; Swinhoe, N.; Cleves, P.; Craggs, J.; Fujita, S.; Nakajima, Y.; Steenbergen, P.; Diz-Munoz, A.; Salbreux, G.; Ikmi, A.
10.1101/2025.02.07.637025 — developmental biology — Posted on 2025-02-08
3628 Structural basis of flagellar rod assembly on the FliPQR protein-export channel
Kinoshita, M.; Miyata, T.; Makino, F.; Imada, K.; Namba, K.; Minamino, T.
10.1101/2025.02.07.637169 — microbiology — Posted on 2025-02-08
3629 Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
Abir, A. H.; Benz, J.; Frey, B.; Bruns, H.; gaipl, U.; Schober, K.; Mougiakakos, D.; Mielenz, D.
10.1101/2025.02.06.636644 — immunology — Posted on 2025-02-08
3630 A Dapl1+ subpopulation of naive CD8 T cells contains committed precursors of memory lineage.
Lynch, A. C.; Hioki, K. A.; Liang, X.; Thesmar, I.; Cernjul, J.; He, X.; Mager, J.; Cui, W.; Alfandari, D.; Pobezinskaya, E. E.; Pobezinsky, L. A.
10.1101/2025.02.06.636941 — immunology — Posted on 2025-02-08
3632 TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni.
Inclan Rico, J.; Stephenson, A.; Napuri, C. M.; Rossi, H. L.; Hung, L.-Y.; Pastore, C. F.; Luo, W.; Herbert, D.
10.1101/2025.02.06.636930 — immunology — Posted on 2025-02-08
3633 MAIT cells protect in severe pneumococcal pneumonia by regulating neutrophil/macrophage antimicrobial activities
Barsac, E.; Gonzalez, L.; Ilango, G.; Hankard, A.; Jouan, Y.; Lemoine, R.; Minhas, V.; Lenain, M.; Benard, M.; Fernandez, M.; Gaudio, A.; Si-Tahar, M.; Guillon, A.; Mallevaey, T.; Ganskow, C. S. G.; Klahn, P.; Veening, J.-W.; Salou, M.; Lantz, O.; Baranek, T.; Paget, C.
10.1101/2025.02.07.637027 — immunology — Posted on 2025-02-08
3637 Glutamatergic synaptic resilience to overexpressed human alpha-synuclein
Santos, P. I.; Garcia-Plaza, I. H.; Shaib, A.; Rhee, J. S.; Chouaib, A. A.; Rizzoli, S. O.; Daniel, J.; Outeiro, T. F.
10.1101/2025.02.06.636960 — neuroscience — Posted on 2025-02-08
3640 Divergence of Functional Brain Network Configurations in Same and Other Race Face Recognition
Yaros, J.; Houalla, B.; McMillan, L.; Larson, M. S.; Yu, G.; Hollearn, M.; Hollearn, M.; Miranda, B.; Jirsaraie, R.; Salama, D.; Rapp, P.; Yassa, M. A.
10.1101/2025.02.06.636962 — neuroscience — Posted on 2025-02-08
3641 Hidden in plain sight: Discovery of sand flies in Singapore and description of four species new to science
Ding, H.; Torno, M.; Vongphayloth, K.; Ng, G.; Tan, D.; Sng, W.; Ho, K.; Randrianambinintsoa, F. J.; Depaquit, J.; Tan, C. H.
10.1101/2025.02.06.636818 — zoology — Posted on 2025-02-08
3642 Deep origins and distinct adaptations indicated for a glacial relict seal
Loytynoja, A.; Pohjoismaki, J.; Valtonen, M.; Laakkonen, J.; Morita, W.; Kunnasranta, M.; Vainola, R.; Olsen, M. T.; Auvinen, P.; Jernvall, J.
10.1101/2025.02.06.636115 — zoology — Posted on 2025-02-08
3643 TaWUS2D regulates the number of grains per spikelet by enhancing the number of fertile ovaries in Multi-Ovary Wheat
Schoen, A. W.; Sharma, P. K.; Mahlandt, A.; Chen, A.; Sheng, H.; Kochian, L.; Gao, P.; Xiang, D.; Quilichini, T.; Venglat, P.; Wang, S.; Yadav, I. S.; Gu, Y.; Rodriguez-Leal, D.; Luo, W.; Qi, Y.; Meier, N.; Kajla, A.; Willman, M.; Brown-Guedira, G.; Youngblood, C.; Hulse-Kemp, A.; Murphy, A.; Gill, B.; Uauy, C.; Datla, R.; Rawat, N.; Tiwari, V.
10.1101/2025.02.05.636547 — plant biology — Posted on 2025-02-08
3644 CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis
Binenbaum, J.; Adamkova, V.; Fryer, H.; Xu, L.; Gorringe, N.; Wlodzimierz, P.; Burns, R.; Papikian, A.; Jacobsen, S. E.; Henderson, I.; Harris, C. J.
10.1101/2025.02.07.636860 — plant biology — Posted on 2025-02-08
3645 Sex-dependent effects of intestinal epithelial TLR4 deletion induced before activity-based anorexia
Salaun, C.; Hure, M.; Guerin, C.; Bole-Feysot, C.; Leon, F.; Lenoir, S.; do Rego, J. L.; do Rego, J. C.; Langlois, L.; Ribet, D.; Achamrah, N.; Coeffier, M.
10.1101/2025.02.05.636626 — physiology — Posted on 2025-02-08
3646 Pathology of Influenza A (H5N1) infection in pinnipeds reveals novel tissue tropism and vertical transmission.
Fiorito, C. D.; Colom, A.; Fernandez, A.; Alonso Almorox, P.; Andrada, M.; Lombardo, D.; Sierra, E.
10.1101/2025.02.07.636856 — pathology — Posted on 2025-02-08
3647 Systems Pharmacology Screening Reveals Mertk and other Targetable Kinases in Supratentorial Ependymomas
Chan, M.; Zhu, S.; Russell, Z.; Arora, S.; Arakaki, A.; Kumasaka, D.; Szulzewsky, F.; Michealraj, A.; Holland, E.; Gujral, T.
10.1101/2025.02.06.636949 — cancer biology — Posted on 2025-02-08
3648 Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment
Dubrova, A.; Cavaniol, C.; Van de Walle, A.; Mathieu, P.; Fusilier, Z.; Yaacoub, N.; Lalatonne, Y.; Descroix, S.; Wilhelm, C.
10.1101/2025.02.06.636875 — cancer biology — Posted on 2025-02-08
3649 Targeting BRAF kinase fusions with pan-RAF and vertical MAPK inhibition
Turner, J. A.; MacBeth, M. L.; Bagby, S. M.; Whitty, P.; Hartman, S. J.; Simmons, D.; Pitts, T. M.; Yacob, B.; Robinson, W. A.; Couts, K.
10.1101/2025.02.06.636895 — cancer biology — Posted on 2025-02-08
3655 Lipopolysaccharides nanodiscs, a biomimetic platform to study bacterial surface.
Abbas, M.; Micciulla, S.; Teulon, J.-M.; Maalej, M.; Trembley, M.; Marchetti, R.; Molinaro, A.; Thepaut, M.; Fieschi, F.; Pellequer, J.-L.; Laguri, C.
10.1101/2025.02.05.636646 — biophysics — Posted on 2025-02-08
3656 Mechanical comparison of Escherichia coli biofilms with altered matrix composition: a study combining shear-rheology and microindentation
Siri, M.; Sarlet, A.; Ziege, R.; Zorzetto, L.; Sotelo Guzman, C.; Amini, S.; Hengge, R.; Blank, K. G.; Bidan, C. M.
10.1101/2025.02.07.637005 — biophysics — Posted on 2025-02-08
3658 Inverse modeling of heterogeneous ECM mechanical properties in nonlinear 3DTFM
Apolinar-Fernandez, A.; Barrasa-Fano, J.; Van Oosterwyck, H.; Sanz-Herrera, J. A.
10.1101/2025.02.06.636898 — biophysics — Posted on 2025-02-08
3663 The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments
Li, T.; Alvarez, M.; Liu, C.; Abuhanna, K.; Sun, Y.; Ernst, J.; Plath, K.; Balliu, B.; Luo, C.; Zaitlen, N.
10.1101/2025.02.06.636969 — bioinformatics — Posted on 2025-02-08
3668 Unraveling diversity by isolating peptide sequences specific to distinct taxonomic groups
Bochalis, E.; Patsakis, M.; Chantzi, N.; Mouratidis, I.; Chartoumpekis, D.; Georgakopoulos Soares, I.
10.1101/2025.02.05.636664 — bioinformatics — Posted on 2025-02-08
3669 Delayed lubricin injection improves cartilage repair tissue quality in an in vivo rabbit osteochondral defect model
Yoon, D.; Vishwanath, K.; Dankert, J.; Butler, J. J.; Azam, M. T.; Gianakos, A. T.; Colville, M. J.; Lopez, S. G.; Paszek, M. J.; Reesink, H. L.; Kennedy, J. G.; Bonassar, L. J.; Irwin, R. M.
10.1101/2025.02.06.636825 — bioengineering — Posted on 2025-02-08
3670 All-trans retinoic acid and fluid transport in myopigenesis
Dvoriashyna, M.; Bentley-Ford, M. R.; Yu, J.; Chatterjee, S.; Pardue, M.; Kane, M. A.; Repetto, R.; Ethier, C. R.
10.1101/2025.02.05.636685 — bioengineering — Posted on 2025-02-08
3671 CD4+ Mucosal-associated Invariant T (MAIT) cells express highly diverse T cell receptors
Kaur, R.; Mehanna, N.; Pradhan, A.; Xie, D.; Li, K.; Aube, J.; Rosati, B.; Carlson, D.; Vorkas, C. K.
10.1101/2025.02.06.636785 — genomics — Posted on 2025-02-08
3673 ERGA-BGE Reference Genome of Loboptera subterranea: a cave adapted cockroach endemic to the Canary Islands
Lopez, H.; Oromi, P.; Belles, X.; Ylla, G.; Escudero, N.; Fernandez, R.; Böhne, A.; Gut, M.; Aguilera, L.; Alioto, T.; Ferreira, F. C.; Gomez-Garrido, J.; Cruz, F.; Monteiro, R.
10.1101/2025.02.06.636782 — genomics — Posted on 2025-02-08
3675 Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle
Hearn, J.; van Mol, W.; Meyermans, R.; Bartley, K.; Alioto, T.; Gomez-Garrido, J.; Cruz, F.; Camara Ferreira, F.; Gut, M.; Gut, I. G.; Buys, N.; Janssens, S.; Adams, K.; Roose, S.; Van Leeuwen, T.; Dermauw, W.; Gilleard, J. S.; Avramenko, R.; Geldhof, P.; Claerebout, E.; Burgess, S. T. G.
10.1101/2025.02.06.636820 — genomics — Posted on 2025-02-08
3680 Asymmetric subspecies-selection of an NLR-TF immune module and reconstruction of broad-spectrum disease resistance in rice
Hui, L.; dan, C. F.; yun, C. G.; xiao, Y. B.; Meng, Y.; Jie, Q.; Ying, C.; jie, W. Y.; xuan, C. K.; yu, G. X.; sha, L. S.; yun, L. J.; jun, W. J.; bai, L. R.; zeng, M. B.; long, X. J.; Seong, J. J.; hui, H. X.; Bin, H.; wen, D. Y.; you, C. G.; hua, H. Z.
10.1101/2025.02.06.636770 — genetics — Posted on 2025-02-08
3682 Parasite-mediated inbreeding depression in wild red deer
Hasik, A. Z.; Hewett, A.; Maris, K.; Morris, S.; Morris, A.; Albery, G. F.; Pemberton, J. M.
10.1101/2025.02.06.636807 — ecology — Posted on 2025-02-08
3683 Beyond Proxies: Towards ecophysiological indicators of drought resistance for forest management
COPIE, A.; Scotti-Saintagne, C.; Lefevre, F.; Cochard, H.; Delzon, S.; Dumas, P.-J.; Gounelle, D.; Herbette, S.; Jean, F.; Mariotte, N.; Mencuccini, M.; Scotti, I.; Martin-StPaul, N.
10.1101/2025.02.06.636586 — ecology — Posted on 2025-02-08
3685 Measuring morphogen transport over multiple spatial scales in live zebrafish embryos
Nelanuthala, A. V. S.; Saha, B.; Sankaran, J.; Carney, T. J.; Sampath, K.; Wohland, T.
10.1101/2025.02.06.636788 — developmental biology — Posted on 2025-02-08
3686 Mitotic polarity oscillation promotes epithelial tumor progression
Jeyanathan, G.; Cao, M. M.; Pellikka, M.; Robinson, S.; Ghorayeb, V.; Talukder, P.; Tepass, U.
10.1101/2025.02.06.636979 — cell biology — Posted on 2025-02-08
3687 Primitive steroidogenesis in mast cells: A novel regulatory mechanism for mast cell function
Pramanik, J.; Zhao, Q.; Yamashita-Kanemaru, Y.; Hussein, H.; Homer, N. Z. M.; Chakraborty, S.; Shaji, S. K.; Okkenhaug, K.; Roychoudhuri, R.; Mahata, B.
10.1101/2025.02.05.636621 — immunology — Posted on 2025-02-08
3688 A self-assembling cross-protective antigen against multiple Gram-positive nosocomial pathogens
Kramarska, E.; Romero-Saavedra, F.; Squeglia, F.; La Manna, S.; SADONES, O.; Marasco, D.; berisio, R.; Huebner, J.
10.1101/2025.02.06.636879 — immunology — Posted on 2025-02-08
3690 Recent thymic emigrants are preferentially recruited into the memory pool during persistent infection
Hilt, Z. T.; Reynaldi, A.; Steinhilber, M.; Zhang, S.; Wesnak, S. P.; Smith, N. L.; Davenport, M. P.; Rudd, B. D.
10.1101/2025.02.06.636722 — immunology — Posted on 2025-02-08
3692 Testing the Vogt-Bailey Index using task-based fMRI across pulse sequence protocols
Galea, K.; Escudero, A. A.; Attard-Montalto, N.; Vella, N.; Smith, R. E.; Farrugia, C.; Galdi, P.; Scerri, K.; Butler, L.; Bajada, C. J.
10.1101/2025.02.06.636866 — neuroscience — Posted on 2025-02-08
3693 KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration
Zdradzinski, M. D.; Vaughn, L. S.; Matoo, S.; Trumball, K.; Loomis, A.; Thames, E.; Lee, S. J.; Perrone-Bizzozero, N.; Lu, Q.; Larsen, J.; Twiss, J. L.
10.1101/2025.02.06.636857 — neuroscience — Posted on 2025-02-08
3698 The Proteomics Landscape of Pattern Triggered Immunity in the Arabidopsis Leaf Apoplast
Chen, H.-C.; Newton, C. J.; Zheng, Y.; Kong, F.; Yao, Y.; Yang, L.; Kvitko, B. H.
10.1101/2025.02.06.636724 — plant biology — Posted on 2025-02-08
3699 An oomycete effector that induces shade avoidance like growth and suppresses plant defenses targets the AUX/IAA protein IAA11
Bogino, M. F.; Lapegna Senz, J. M.; Tamagnone, N.; Kourdova, L. T.; Romanowski, A.; Wirthmueller, L.; Fabro, G.
10.1101/2025.02.06.636700 — plant biology — Posted on 2025-02-08
3700 Sorting F. graminearum core effector candidates shows multiple fungal proteins that target the wheat cell nucleus during Fusarium Head Blight
Ayilalath, S.; Faurie, L.; Vanrobays, E.; Rocher, F.; Loizeau, L.; Philippe, G.; Javelle, M.; Bosio, M.; Sallaud, C.; Tatout, C.; BONHOMME, L.
10.1101/2025.02.05.636710 — plant biology — Posted on 2025-02-08
3701 Shoot at Site: Advancing in planta transformation, regeneration and gene-editing through a cascade of wounding-mediated developmental regulators
Kshetry, A.; Ghose, K.; Alok, A.; Devkar, V.; Raman, V.; Stupar, R. M.; Herrera Estrella, L.; Zhang, F.; Patil, G. B.
10.1101/2025.02.06.636944 — plant biology — Posted on 2025-02-08
3702 Cardiac-specific deletion of GCN5L1 promotes fatty liver disease in HFpEF
Bugga, P.; Mushala, B. A.; Stoner, M. W.; Manning, J. R.; Bhattarai, N.; Sharifi-Sanjani, M.; Vandevender, A.; Mooli, R. G.; Ramakrishnan, S. K.; Kaufman, B. A.; Shiva, S. S.; Happe, C. L.; Mullett, S. J.; Gelhaus, S. L.; Jurczak, M. J.; Scott, I.
10.1101/2025.02.05.636634 — physiology — Posted on 2025-02-08
3703 Increased contact between lipid droplets and mitochondria in skeletal muscles of male elite endurance athletes
Nielsen, J.; Petersen, K. G.; de Almeida, M. E.; Shepherd, S. O.; Christensen, B.; Petersen, M. H.; Hojlund, K.; Ortenblad, N.; Gejl, K. D.
10.1101/2025.02.05.636640 — physiology — Posted on 2025-02-08
3705 LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung Cancer
Shah, K. M.; Kennedy, P. T.; Black, J.; Litchfield, K.; Thakkar, K.; Contreras-Gerenas, M. F.; Brooksbank, K.; Yuan, O.; Grevitt, P.; Charrot, S.; Davies, J.; Dahal, L. N.; Lagos, D.; McGranahan, N.; Sharp, T. V.
10.1101/2025.02.06.636805 — cancer biology — Posted on 2025-02-08
3711 Poly-L-Ornithine Coated Plant Scaffolds Support Motor Recovery in Rats after Traumatic Spinal Cord Injury
Couvrette, L.; Walker, K.; Bayat, A.; Modulevsky, D.; Laliberte, A.; Cuerrier, C.; Leblanc Latour, M.; Hickey, R.; Boudria, R.; Monty, R.; Obhi, R.-J.; Shore, I.; Galuta, A.; Tsai, E.; Bui, T.; Pelling, A. E.
10.1101/2025.02.05.636658 — bioengineering — Posted on 2025-02-08
3712 A Sacrificial 3D Printed Vessel-on-Chip Demonstrates a Versatile Approach to Model Connective Tissue Pathology
Jäger, J.; Berger, P.; Morrison, A. I.; Erfurth, H.; Thon, M.; Dehne, E.-M.; Gibbs, S.; Koning, J. J.
10.1101/2025.02.06.636821 — bioengineering — Posted on 2025-02-08
3719 Investigating the dynamics of the aquatic community in Oslofjord through time series analysis of eDNA
Mahlangu, S.; Ewers, I.; Carvalho, C. O.; Schroder-Nielsen, A.; Dunthorn, M.; Karlsen, H. E.; Sornes, G.; Chavarie, L.; Endresen, D.; Ready, J. S.; de Boer, H. J.; Mauvisseau, Q.
10.1101/2025.02.05.636659 — ecology — Posted on 2025-02-08
3720 An in vivo screen for proteolytic switches that can mediate Notch activation
Baker, F.; Harman, J.; Jordan, T.; Walton, B.; Ajamu-Johnson, A.; Alashqar, R.; Bhikot, S.; Struhl, G.; Langridge, P. D.
10.1101/2024.07.10.602225 — cell biology — Posted on 2025-02-08
3724 Natural Variation in Photoprotection: Rapid NPQ Kinetics in Ferns
Maryn, N.; Chaparro, A.; Short, A.; Fleming, G. R.; Niyogi, K. K.
10.1101/2025.02.07.637181 — plant biology — Posted on 2025-02-08
3726 Cryo-EM reveals a new allosteric binding site at the M5 mAChR
Burger, W. A. C.; Mobbs, J. I.; Rana, B.; Wang, J.; Joshi, K.; Gentry, P. R.; Yeasmin, M.; Venugopal, H.; Bender, A.; Lindsley, C. W.; Miao, Y.; Christopoulos, A.; Valant, C.; Thal, D. M.
10.1101/2025.02.05.636602 — pharmacology and toxicology — Posted on 2025-02-08
3728 6-thio-2-deoxyguanosine inhibits telomere elongation by inducing a non-productive stalled telomerase complex
Sanford, S. L.; Badstubner, M.; Gerber, M.; Mannherz, W.; Lampl, N.; Dannenberg, R.; Hinchie, A.; Schaich, M. K.; Myong, S.; Hedglin, M.; Agarwal, S.; Alder, J. K.; Stone, M.; Opresko, P. L.
10.1101/2025.02.05.636339 — cancer biology — Posted on 2025-02-08
3735 Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion
Altun, I.; Walia, S.; Yan, X.; Singh, I.; Karlina, R.; Miok, V.; Kang, L.; Ho Diep Vo, K.; Lutter, D.; Perrochi, F.; Ussar, S.
10.1101/2025.02.08.637214 — developmental biology — Posted on 2025-02-08
3737 Intraspecies associations from strain-rich metagenome samples
Qu, E. B.; Baker, J. S.; Markey, L.; Khadka, V. D.; Mancuso, C. P.; Tripp, A. D.; Lieberman, T. D.
10.1101/2025.02.07.636498 — microbiology — Posted on 2025-02-08
3738 Persistent glycolysis defines the foreign body response to polymeric implants.
Rempe, C.; Callaghan, N.; Fong-Hollohan, L.; Nersesian, S.; Froom, Z.; Medd, K.; Ahmed, I.; Karakach, T.; Boudreau, J.; Bezuhly, M.; Davenport Huyer, L.
10.1101/2025.02.04.636531 — immunology — Posted on 2025-02-08
3740 DHRS7 Integrates NADP+/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway
Ma, Y.; Hui, K. L.; Ambaw, Y. A.; Walther, T. C.; Farese, R. V.; Lengyel, M.; Gelashvili, Z.; Lu, D.; Niethammer, P.
10.1101/2025.02.05.636725 — immunology — Posted on 2025-02-08
3741 NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
Turiello, R.; Ng, S. S.; Tan, E.; Voort, G. v. d.; Salim, N.; Yong, M.; Khassenova, M.; Oldenburg, J.; Rühl, H.; Hasenauer, J.; Surace, L.; Toma, M.; Bald, T.; Hölzel, M.; Corvino, D.
10.1101/2025.02.05.636622 — immunology — Posted on 2025-02-08
3743 Identification of Amblyomma americanum antigens after vaccination with tick extracellular vesicles in white-tailed deer
Oliva Chavez, A.; Gonzalez Gonzalez, J.; Harvey, C.; Ribeiro-Silva, C. d. S.; Leal-Galvan, B.; Persinger, K. A.; Durski, S.; Olafson, P. U.; Johnson, T. L.
10.1101/2025.02.03.636374 — immunology — Posted on 2025-02-08
3744 A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity
Nickl, V.; Hübner, J.; Alsalkini, M.; McFleder, R.; Wagner, J.; Liguori, R.; Grams, B.; Meyer-Hofmann, M.; Diener, L.; Monoranu, C. M.; Hagemann, C.; Ferrazzi, F.; Ip, C. W.; Ernestus, R.-I.; Einsele, H.; Hudecek, M.; Löhr, M.; Nerreter, T.
10.1101/2025.02.03.636223 — immunology — Posted on 2025-02-08
3745 IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
Fike, A. J.; Bricker, K. N.; Gonzalez, M. V.; Maharjan, A.; Bui, T.; Nuon, K.; Emrich, S. M.; Weber, J. L.; Luckenbill, S. A.; Choi, N. M.; Sauteraud, R.; Liu, D.; Olsen, N.; Caricchio, R.; Trebak, M.; Chodisetti, S. B.; Rahman, Z. S. M.
10.1101/2025.02.04.636277 — immunology — Posted on 2025-02-08
3750 Spatial transcriptomics reveals heterogeneous cell-cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesions
Tsai, H.-H.; Piya, S.; Wang, J.; Zhu, J.; Hu, W.; Gehrke, A. R.; Cao, S.; Guise, A. J.; Chan, S. J.; Sheehan, M.; Chu, J.; Ouyang, Z.; Ryals, M.; Lee, M.; Wang, W.; Zhao, E.; Cullen, P.; Challa, R.; Marshall, E.; Zeng, W.; Kaeser-Woo, Y. J.; Ehrenfels, C.; Jandreski, L.; McLaughlin, H.; Carlile, T. M.; Gagnon, J.; Reynolds, T. L.; Li, M.; Li, K.; Zhang, B.
10.1101/2025.02.07.637125 — neuroscience — Posted on 2025-02-08
3751 The Cause of Most Common Antler Abnormality is Not a Fracture But an Osteomyelitis Like Disease the Pedunculitis Chronica Deformans
Sukosd, F.; Lakatos, I.; Urmos, A.; Babarczi, B.; Skoda, G.; Molnar, Z.; Pankotai, T.; Borsos, B. N.; Karkas, R.; Sukosd, A.; Palanki, G.; Dobrosy, S.; Toth, A. A.; Erdelyi, K.; Horvath, G.; Horvath, A.; Toth, D.; Maurer, M.; Miso, M.; Plank, P.; Czeh, A.; Nagyeri, G.; Ferenczi, S.; Gobolos, P.; Kemenesi, G.; Posta, K.; Kovacs, F.; Mezes, M.; Szemethy, L.; Szoke, Z.
10.1101/2025.02.05.636259 — zoology — Posted on 2025-02-08
3756 High-content morphological profiling by Cell Painting in 3D spheroids.
Ringers, C.; Holmberg, D.; Flobak, A.; Georgiev, P.; Jarvius, M.; Johansson, M.; Larsson, A.; Rosen, D.; Seashore-Ludlow, B.; Visnes, T.; Carreras-Puigvert, J.; Spjuth, O.
10.1101/2025.02.05.636642 — pharmacology and toxicology — Posted on 2025-02-08
3757 Anti-Diabetic Effects of Nigella sativa and Cichorium intybus in Animal Experimental Model
Kashif, M.; Nasir, A.; Aziz, M. K.; ur Rehman, A.; Vincent, T.; Gonzalez, J.-P.; Waheed, U.
10.1101/2025.02.03.636360 — pathology — Posted on 2025-02-08
3759 Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations
Hafner, P.; Keller, S.; Chen, X.; Alrawashdeh, A.; Jumaa, H.; Nollmann, F.; Besson, S.; Kemming, J.; Gorka, O.; Das, T.; Appiah, B.; Lehmann, A.; Li, M.; Apostolova, P.; Bengsch, B.; Tholen, S.; Schilling, O.; Gross, O.; Vlachos, A.; Wittel, U.; von Elverfeldt, D.; Reichardt, W.; Boerries, M.; Andrieux, G.; Heynen, G.; Fichtner-Feigl, S.; Hannibal, L.; Ruess, D.
10.1101/2025.02.03.636222 — cancer biology — Posted on 2025-02-08
3760 PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer
Cunningham, M. L.; Vasquez-Gonzalez, J.; Barnada, S. M.; Tchotorlishvili, S.; Jones, L.; Shankle, H. N.; Mulderes, T.; Ajmal, N.; Solomides, C.; Shafi, A. A.; Gomella, L. G.; Kelly, W. K.; McMahon, S. B.; Schiewer, M. J.
10.1101/2025.02.05.636297 — cancer biology — Posted on 2025-02-08
3765 Peptide-induced hydration of lipid bilayers modulates packing pattern and conformations of hydrocarbon chains - a potential pathway for peptide translocation?
Pasalic, L.; Pem, B.; Jakas, A.; Cikos, A.; Groznica, N.; Mlinaric, T.; Accorsi, M.; Mangiarotti, A.; Dimova, R.; Bakaric, D.
10.1101/2025.02.04.636480 — biophysics — Posted on 2025-02-08
3770 Single-Cell Transcriptomics Reveals Dynamic Microglial States and Neural-Immune Networks in Human Diabetic Retinopathy
Yang, L.; Lin, S.; Tao, Y.; Pan, Q.; Cai, T.; Ye, Y.; Liu, J.; Zhou, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Shao, Y.; Meng, W.
10.1101/2025.02.07.637193 — bioinformatics — Posted on 2025-02-08
3772 Evaluation of sequencing reads at scale using rdeval
Formenti, G.; Koo, B.; Sollitto, M.; Balacco, J.; Brajuka, N.; Burhans, R.; Duarte, E.; Giani, A. M.; McCaffrey, K.; Medico, J. A.; Myers, E. W.; Smeds, P.; Nekrutenko, A.; Jarvis, E. D.
10.1101/2025.02.01.636073 — bioinformatics — Posted on 2025-02-08
3776 Fast and Accurate in silico Antigen Typing with Kaptive 3
Stanton, T. D.; Hetland, M. A. K.; Lohr, I. H.; Holt, K.; Wyres, K. L.
10.1101/2025.02.05.636613 — bioinformatics — Posted on 2025-02-08
3778 Harnessing Adaptive Chaos: Exploring the role of oxygen-ozone therapy in modulating complexity and repair in spine disorders via a bio-informatic model
Chirumbolo, S.; Franzini, M.; Tirelli, U.; Ricevuti, G.; Loprete, F.; Richelmi, T.; Vaiano, F.; Galoforo, A. C.; Chierchia, M.; Valdenassi, L.
10.1101/2025.02.05.636618 — bioinformatics — Posted on 2025-02-08
3781 Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions
Yang, J.; Agrawal, K.; Stanley, J. S.; Li, R.; Jacobs, N.; Wang, H.; Lu, C.; Qu, R.; Clarke, D.; Chen, Y.; Jiang, Y.; Bai, D.; Zheng, S.; Fox, H.; Ho, Y.-C.; Huttner, A.; Gerstein, M.; Kluger, Y.; Zhang, L.; Spudich, S.
10.1101/2025.02.05.636707 — bioinformatics — Posted on 2025-02-08
3782 Monitoring Whole-Body Inflammation with Gallium-68 Labeled Polydopamine Iron Oxide Particles via Hybrid Immuno-PET-MRI
Pedron, S.; Guillou, A.; Fillesoye, F.; Jacqmarcq, C.; Perrio, C.; Caruso, F.; Li, S.; Ju, Y.; Vivien, D.; Gauberti, M.; Vigne, J.; Bonnard, T.
10.1101/2025.02.04.636474 — bioengineering — Posted on 2025-02-08
3783 Encapsidic production and isolation of degradation-prone polypeptides
Gawin, A.; Pankowski, J.; Zarechyntsava, M.; Kwasna, D.; Kloska, D.; Koziej, L.; Glatt, S.; Kachamakova-Trojanowska, N.; Azuma, Y.
10.1101/2025.02.04.636450 — bioengineering — Posted on 2025-02-08
3785 A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex
Letner, J. G.; Lam, J. L. W.; Copenhaver, M. G.; Barrow, M.; Patel, P. R.; Richie, J. M.; Lee, J.; Kim, H.-S.; Cai, D.; Weiland, J. D.; Phillips, J.; Blaauw, D.; Chestek, C. A.
10.1101/2025.02.05.636655 — bioengineering — Posted on 2025-02-08
3791 Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic Diseases
Roussange, F.; Gide, J.; Tournois, J.; Cailleret, M.; Boland, A.; Battail, C.; Deleuze, J.-F.; Polveche, H.; Auboeuf, D.; Brockmann, K.; Kabashi, E.; Marian, A.; El Kassar, L.; Blondel, S.; Salachas, F.; Bruneteau, G.; Peschanski, M.; Martinat, C.; Baghdoyan, S.
10.1101/2025.02.04.636445 — genomics — Posted on 2025-02-08
3792 CobVar - a comprehensive resource of Vitamin B 12-associated genomic variants
HS, N.; Kilpady, C. A.; Kamath, A. A.; Ahmed, A.; Kurpad, A. V.; Thomas, T.; Sivadas, A.
10.1101/2025.02.05.636608 — genomics — Posted on 2025-02-08
3794 Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study
Chen, X.; Wang, H.; Broce, I.; Dale, A. M.; Yu, B.; Zhou, L. Y.; Li, X.; Argos, M.; Daviglus, M. L.; Cai, J.; Franceschini, N.; Sofer, T.
10.1101/2025.02.04.636481 — genetics — Posted on 2025-02-08
3796 rsofun v5.0: A model-data integration framework for simulating ecosystem processes
Aran Paredes, J.; Hufkens, K.; Marcadella, M.; Bernhard, F.; Stocker, B. D.
10.1101/2023.11.24.568574 — ecology — Posted on 2025-02-08
3797 Functional diversity of soil microbial communities increases with ecosystem development
Ranheim Sveen, T.; Viketoft, M.; Bengtsson, J.; Lejoly, J.; Buegger, F.; Pritsch, K.; Strengbom, J.; Fritscher, J.; Hildebrand, F.; Osburn, E.; Hannula, E.; Bahram, M.
10.1101/2025.02.05.636575 — ecology — Posted on 2025-02-08
3798 Consumer resilience suppresses the recovery of overgrazed ecosystems
Spindel, N. B.; Galloway, A. W. E.; Schram, J. B.; Mcneill, G. D.; Bellis, S. K. V.; Guujaaw, N.; Yakgujanaas, J.; Pontier, O.; Thompson, M.; Lee, L. C.; Okamoto, D.
10.1101/2025.02.04.636488 — ecology — Posted on 2025-02-08
3800 A Multi-Model Ensemble Reveals Soil Carbon Gains from Regenerative Practices in the U.S. Midwest Cropland
Basso, B.; Tadiello, T.; Millar, N.; Maureira, F.; Albarenque, S.; Baer, B.; Price, L.; Sharma, P.; Villalobos, C.; Paustian, K.; Fowler, A.; Delandmeter, M.; Acutis, M.; Archontoulis, S.; Covey, K.; Doro, L.; Dumont, B.; Grace, P.; Hoogenboom, G.; Jones, J. W.; Perego, A.; Robertson, G. P.; Ruane, A.; Stockle, C.; Zhang, Y.
10.1101/2025.02.04.636509 — ecology — Posted on 2025-02-08
3802 Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Han, W.; Yuan, B.; Fan, X.; Li, W.; Yuan, Y.; Zhang, Y.; Wang, S.; Shan, S.; Hafner, M.; Wang, Z.; Qiu, Z.
10.1101/2025.02.04.636546 — molecular biology — Posted on 2025-02-08
3804 HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammation
Kuzmina, M.; Grusanovic, S.; Brezina, J.; Milosevic, M.; Vanickova, K.; Pavliuchenko, N.; Ruzickova, S.; Rohlena, J.; Filipp, D.; Rohlenova, K.; Brdicka, T.; Alberich-Jorda, M.
10.1101/2025.02.05.636492 — immunology — Posted on 2025-02-08
3805 Essential role of NLRC5 in cancer immune surveillance and cancer immunoediting
Shukla, A.; Cayarga, A. A.; Lucier, J.-F.; Santharam, M. A.; Levesque, D.; Boisvert, F.-M.; Ramanathan, S.; Ilangumaran, S.
10.1101/2025.02.03.636144 — immunology — Posted on 2025-02-08
3806 Single-cell RNA-seq reveals altered plasma cell subsets and decreased cytotoxicity of NK cells in patients with Kawasaki diseas
Zhou, Y.; Liu, Y.; Liu, L.; Shen, X.; Wen, X.; Lin, G.; Tang, L.; Li, Q.; Gan, J.; Li, R.; Shang, J.; Li, L.
10.1101/2025.02.03.636324 — immunology — Posted on 2025-02-08
3807 Immune-induced TCR-like antibodies regulate specific T cell response
Kishida, K.; Kawakami, K.; Tanabe, H.; Nakai, W.; Yonekura, K.; Yokoyama, S.; Arase, H.
10.1101/2025.02.03.636362 — immunology — Posted on 2025-02-08
3808 Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response
Lika, J.; Votava, J. A. A.; Datta, R.; Kralovec, A. M.; Smith, F. M.; Huttenlocher, A.; Skala, M. C.; Fan, J.
10.1101/2025.02.03.636312 — immunology — Posted on 2025-02-08
3809 Circulating extracellular vesicles from HIV-1 gp120-treated mice act as endogenous algogens, mediating and maintaining HIV-associated chronic pain
Yuan, S.; Liew, J. Y.; Bei, J.; Pal, A.; Qiu, Y.; Shang, J.; Araya, K.; Tat, V.; Hao, H.; Gamez, I.; Haines, C.; Chang, Q.; Saito, T. B.; Khanipov, K.; Gong, B.
10.1101/2025.02.07.637192 — neuroscience — Posted on 2025-02-08
3812 Near-cognate tRNAs dominate codon decoding times in simulated ribosomes
Hedayioglu, F.; Mead, E. J.; Kurusamy, S.; Thaventhiran, J. E.; Willis, A. E.; Smales, C. M.; von der Haar, T.
10.1101/2025.02.04.636423 — systems biology — Posted on 2025-02-08
3815 Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide.
Rong, Y.; Zhang, Z.; de Jonge, H.; Lin, R.-X.; Yu, H.; Sarker, R.; Boffelli, D.; Zwick, R. K.; Klein, O.; Tse, M.; Donowitz, M. K.; Singh, V.
10.1101/2025.02.03.636268 — physiology — Posted on 2025-02-08
3817 Transcription factor 19 is an androgen responsive gene that modulates vessel homeostasis and sustains metastatic prostate cancer
Carracedo, A.; Ercilla, A.; Crespo, J. R.; Garcia-Longarte, S.; Fidalgo, M.; Martin-Martin, N.; Carlevaris, O.; Astobiza, I.; Fernandez-Ruiz, S.; Guiu, M.; Barcena, L.; Mendizabal, I.; Aransay, A. M.; Graupera, M.; Gomis, R. R.
10.1101/2025.02.04.636232 — cancer biology — Posted on 2025-02-08
3819 A Bio-inspired Latent TGF-β Conjugated Scaffold Improves Neocartilage Development
Wang, T.; Maldonado, C. C.; Huang, B.-L.; Budbazar, E.; Martin, A.; Layne, M. D.; Murphy-Ullrich, J. E.; Grinstaff, M. W.; Albro, M. B.
10.1101/2025.02.03.636279 — bioengineering — Posted on 2025-02-08
3820 Seq-Scope-eXpanded: Spatial Omics Beyond Optical Resolution
Anacleto, A.; Cheng, W.; Feng, Q.; Cho, C.-S.; Hwang, Y.; Kim, Y.; Si, Y.; Park, A.; Hsu, J.-E.; Schrank, M.; Teles, R.; Modlin, R. L.; Plazyo, O.; Gudjonsson, J. E.; Kim, M.; Kim, C. H.; Han, H.-S.; Kang, H. M.; Lee, J. H.
10.1101/2025.02.04.636355 — genomics — Posted on 2025-02-08
3823 Volatile-Mediated Plant Defense Networks: Field Evidence for Isoprene as a Short-Distance Immune Signal
Zhu, P.; Weber, B.; Rosenkranz, M.; Polle, A.; Ghirardo, A.; Muhr, J.; Vlot, C.; Schnitzler, J.-P.
10.1101/2025.02.03.636237 — plant biology — Posted on 2025-02-08
3824 Persistent fatty acid catabolism during plant oil synthesis
Koley, S.; Jyoti, P.; Lingwan, M.; Wei, M.; Xu, C.; Chu, K.; Williams, R.; Koo, A. J.; Thelen, J. J.; Xu, D.; Allen, D. K.
10.1101/2025.02.03.636323 — plant biology — Posted on 2025-02-08
3825 Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation
Niklas, B.; Moreau, E.; Deshayes, C.; Rydzewski, J.; Jankowska, M.; Kesy, J.; Martins, A. J.; Mueller, P.; Corbel, V.; Nowak, W.; Lapied, B.
10.1101/2025.02.03.636193 — pharmacology and toxicology — Posted on 2025-02-08
3826 Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis
Margraf, A.; Chen, J.; Christoforou, M.; Claria-Ribas, P.; Henriques Schneider, A.; Cecconello, C.; Bu, W.; Imbert, P. R.; Wright, T. D.; Russo, S.; Blacksell, I. A.; Koenis, D. S.; Dalli, J.; Lupisella, J. A.; Wurz, N. R.; Garcia, R. A.; Cooper, D.; Norling, L. V.; Perretti, M.
10.1101/2025.02.03.636210 — pharmacology and toxicology — Posted on 2025-02-08
3827 Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma.
Haller, A.; Gambi, G.; D'Agostino, M.; Davidson, G.; Lallement, A.; Mengus, G.; Nahy, C.; Messaddeq, N.; BEC, G.; Simonetti, A.; Ennifar, E.; Davidson, I.
10.1101/2025.02.03.636228 — cancer biology — Posted on 2025-02-08
3829 EXPERIMENTAL KINETIC MECHANISM OF P53 CONDENSATION-AMYLOID AGGREGATION
Borkosky, S. S.; Peralta Martinez, R.; Armella-Sierra, A.; Esperante, S.; Lizarraga, L.; Garcia-Pardo, J.; Ventura, S.; Sanchez, I. E.; de Prat-Gay, G.
10.1101/2025.02.03.635948 — biophysics — Posted on 2025-02-08
3842 ibaqpy: A scalable Python package for baseline quantification in proteomics leveraging SDRF metadata
Zheng, P.; Audain, E.; Webel, H.; Dai, C.; Klein, J.; Hitz, M.-P.; Sachsenberg, T.; Bai, M.; Perez-Riverol, Y.
10.1101/2025.02.08.637208 — bioinformatics — Posted on 2025-02-08
3846 ChemEmbed: A deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings
Faizan-Khan, M.; Gine, R.; Badia, J. M.; Perez-Ribera, M.; Junza, A.; Vinaixa, M.; Sales-Pardo, M.; Guimera, R.; Yanes, O.
10.1101/2025.02.07.637102 — bioinformatics — Posted on 2025-02-08
3847 Benchmarking, detection, and genotyping of structural variants in a population of whole-genome assemblies using the SVGAP pipeline
Hu, M.; Wan, P.; Chen, C.; Tang, S.; Chen, J.; Wang, L.; Chakraborty, M.; Zhou, Y.; Chen, J.; Gaut, B. S.; Emerson, J. J.; Yi, L.
10.1101/2025.02.07.637096 — bioinformatics — Posted on 2025-02-08
3849 Filamented Light (FLight) Bioprinting of Mini-Muscles with Self-Renewal Potential
Liu, H.; Winkelbauer, M.; Janiak, J.; Kalkan, A. K.; Kim, I.; Chansoria, P.; Bar-Nur, O.; Zenobi, M.
10.1101/2025.02.03.636126 — bioengineering — Posted on 2025-02-08
3855 Psilocybin alters visual-contextual computations
Aqil, M.; de Hollander, G.; Vreugdenhil, N.; Knapen, T.; Dumoulin, S. O.
10.1101/2025.02.06.636848 — neuroscience — Posted on 2025-02-08
3856 Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects
Ertl, N.; Ashraf, I.; Azizi, L.; Roseman, L.; Erritzoe, D.; Nutt, D.; Carhart-Harris, R.; Wall, M. B.
10.1101/2025.02.07.637042 — neuroscience — Posted on 2025-02-08
3863 Organisation of axial regions of isolated mitotic chromosomes visualised by cryo correlative light and electron tomography
Patra, G.; Harastani, M.; Samejima, K.; Remnant, L. C.; Troffer-Charlier, N.; Crucifix, C.; Durand, A.; Marechal, N.; Lutz, Y.; Steyer, A. M.; Yang, Z.; Hagen, W.; Earnshaw, W. C.; Eltsov, M.
10.1101/2025.02.06.636497 — cell biology — Posted on 2025-02-08
3864 Pde5a Deficiency Prevents Diet-Induced Obesity via Adipose cAMP-PKA Activation Enhancing Fat Browning
Campolo, F.; Giampaoli, O.; Barbagallo, F.; Palmisano, B.; Di Maio, A.; Sciarra, F.; Rizzo, F.; Monti, S.; Cardarelli, S.; Assenza, M. R.; Poggiogalle, E.; Patriarca, A.; Sciubba, F.; Filippini, A.; Lenzi, A.; Gianfrilli, D.; Giorgi, M.; Dolci, S.; Naro, F.; Sampaolesi, M.; Riminucci, M.; Mancini, M.; Miccheli, A.; Tessarollo, L.; Venneri, M. A.; Isidori, A. M.
10.1101/2025.02.05.636635 — cell biology — Posted on 2025-02-08
3865 E2A SUMOylation promotes HAdV mediated inhibition of the tumor suppressor p53 during infection
Stubbe, M.; Stubbe, H. C.; Mai, J.; Plank, V.; Hofmann, S.; Goettig, L.; Guenther, T.; Grundhoff, A.; Krebs, S.; Groitl, P.; Mayerle, J.; Hay, R. T.; Dobner, T.; Schreiner, S.
10.1101/2025.02.07.636424 — cell biology — Posted on 2025-02-08
3866 AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications
Stasevich, T. J.; Kimura, H.; Galindo, G.; Maejima, D.; DeRoo, J.; Burlingham, S.; Fixen, G.; Morisaki, T.; Febvre, H.; Hasbrook, R.; Zhao, N.; Ghosh, S.; Mayton, E. H.; Snow, C.; Geiss, B. J.; Ohkawa, Y.; Sato, Y.
10.1101/2025.02.06.636921 — cell biology — Posted on 2025-02-08
3867 Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation
Bhattacharya, S.; Tei, G.; Singh, P. N. P.; Malagola, E.; Eskiocak, O.; He, R.; Kraiczy, J.; Gu, W.; Perlov, Y.; Beyaz, S.; WANG, T. C.; Zhou, Q.; Shivdasani, R. A.
10.1101/2025.02.07.636917 — cell biology — Posted on 2025-02-08
3868 Super-resolution compatible DNA labeling technique reveals chromatin mobility and organization changes during differentiation
Pabba, M. K.; Kuba, M.; Kraus, T.; Celikay, K.; Meyer, J.; Pradhan, S. K.; Maiser, A.; Harz, H.; Leonhardt, H.; Rohr, K.; Hocek, M.; Cardoso, M. C.
10.1101/2025.02.06.636912 — cell biology — Posted on 2025-02-08
3869 Dimethyl sulfoxide primes induced pluripotent stem cells for more efficient nephron progenitor and kidney organoid differentiation
Kearney, H.; Rak-Raszewska, A.; Seijas-Gamardo, A.; Escarda-Castro, E.; Wieringa, P.; Moroni, L.; Mota, C.
10.1101/2025.02.07.637033 — cell biology — Posted on 2025-02-08
3870 Human differentiated adipocytes can serve as surrogate mature adipocytes for adipocyte-derived extracellular vesicle analysis
Butsch, B. L.; Hade, M. D.; Palacio, P. L.; Nguyen, K. T.; Shantaram, D.; Noria, S.; Brethauer, S. A.; Needleman, B. J.; Hsueh, W.; Reategui, E.; Magana, S. M.
10.1101/2025.02.05.636729 — cell biology — Posted on 2025-02-08
3871 Benchmarking copy number aberrations inference tools using single-cell multi-omics datasets
Song, M.; Ma, S.; Wang, G.; Wang, Y.; Yang, Z.; Xie, B.; Guo, T.; Huang, X.; Zhang, L.
10.1101/2024.09.26.615284 — bioinformatics — Posted on 2025-02-08
3875 Insect wings arose with a genetic circuit that extends the useful range of a BMP morphogen
Huang, A.; Cocconi, L.; Nicholls-Mindlin, B.; Alexandre, C.; Salbreux, G.; Vincent, J.-P.
10.1101/2025.02.07.637038 — developmental biology — Posted on 2025-02-08
3878 Multi-protein silencing using WRAP-based nanoparticles: a proof of concept
Konate, K.; Pezzati, I.; Redjatti, K.; Agnel, E.; Vives, E.; Faure, S.; de Santa Barbara, P.; Boisguerin, P.; DESHAYES, S.
10.1101/2025.02.07.637024 — cell biology — Posted on 2025-02-08
3879 Actin Painting: a multicolor fluorescence staining method highlighting cell type-specific differences in the composition of filamentous actin architectures.
Nagasaki, A.; Kijima, S. T.; Shinkai, Y.; Ohtsuka, Y.; Ochiishi, T.; Sasaki, Y. T. F.; Hata, S.; Hirano, K.; Kato, Y.; Doi, M.; Uyeda, T.
10.1101/2025.02.05.636544 — cell biology — Posted on 2025-02-08
3880 A dWDR45 knock-out Drosophila model to decipher the role of autophagy in BPAN
Celle, M.; Aniorte, S.; Issa, A. R.; Jollivet, F.; Falabregue, M.; Jin, H.; Ding, S.; Seugnet, L.; Liao, L.; Lesca, G.; Walter, L.; Mollereau, B.
10.1101/2025.02.06.636873 — cell biology — Posted on 2025-02-08
3883 Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores towards the nucleus
Vadon, C.; Nguyen, X.-N.; Siahaan, V.; Krishnan, A.; Henriot, V.; Chantharath, A.; Burlaud-Gaillard, J.; Roingeard, P.; Janke, C.; Etienne, L.; Fiorini, F.; Magiera, M. M.; CIMARELLI, A.
10.1101/2025.02.06.636796 — cell biology — Posted on 2025-02-08
3885 A biomathematical approaches models to identify human platelet activation signature in response to various agonists
Cognasse, F.; Nguyen, K. A.; Heestermans, M.; Arthaud, C.-A.; Eyraud, M.-A.; Prier, A.; de Bernard, S.; Nourikyan, J.; Duchez, A. C.; Avril, S.; Garraud, O.; Hamzeh-Cognasse, H.
10.1101/2025.02.06.636809 — cell biology — Posted on 2025-02-08
3887 Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics
Dai, A.; Xu, P.; Amos, C.; Fujise, K.; Wu, Y.; Yang, H.; Eisen, J. N.; Guillen-Samander, A.; De Camilli, P.
10.1101/2025.02.07.637094 — cell biology — Posted on 2025-02-08
3898 Accelerating Antibody Development: Sequence and Structure-Based Models for Predicting Developability Properties through Size Exclusion Chromatography
Abeer, A. N. M. N.; Boroumand, M.; Sermadiras, I.; Caldwell, J. G.; Stanev, V.; Mody, N.; Kaplan, G.; Savery, J.; Croasdale-Wood, R.; Pouryahya, M.
10.1101/2025.02.02.636157 — bioinformatics — Posted on 2025-02-08
3899 Design of intrinsically disordered region binding proteins
Wu, K.; Jiang, H.; Hicks, D. R.; Liu, C.; Muratspahic, E.; Ramelot, T. A.; Liu, Y.; McNally, K.; Gaur, A.; Coventry, B.; Chen, W.; Bera, A. K.; Kang, A.; Gerben, S.; Lamb, M. Y.-L.; Murray, A.; Li, X.; Kennedy, M. A.; Yang, W.; Schober, G.; Brierley, S. M.; Gelb, M. H.; Montelione, G. T.; Derivery, E.; Baker, D.; Mihut, A.; O'Neill, J. S.; Song, Z.
10.1101/2024.07.15.603480 — biochemistry — Posted on 2025-02-08
3901 Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia
Wilson, A. M.; Jacobs, M. M.; Lambert, T. Y.; Valada, A.; Meloni, G.; Gilmore, E.; Murray, J.; Morgello, S.; Akbarian, S.
10.1101/2025.02.05.636667 — genomics — Posted on 2025-02-08
3903 Polarity reversal of stable microtubules during neuronal development
Iwanski, M. K.; Serweta, A. K.; Verwei, H. N.; Donders, B. C.; Kapitein, L. C.
10.1101/2025.02.07.636940 — cell biology — Posted on 2025-02-08
3904 The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic state
Salido, E.; de Medeiros Vieira, C.; Verdezoto Mosquera, J.; Zade, R.; Parikh, P.; Suryavanshi, S.; Miller, C. L.; Lo Sardo, V.
10.1101/2024.05.25.595888 — cell biology — Posted on 2025-02-08
3905 A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity
Monzel, A. S.; Devine, J.; Kapri, D.; Enriquez, J. A.; Trumpff, C.; Picard, M.
10.1101/2025.02.03.635951 — cell biology — Posted on 2025-02-08
3906 Control of pili synthesis and putrescine homeostasis in Escherichia coli
Mehta, I.; Hogins, J.; Hall, S.; Vragel, G.; Ambagaspitiye, S.; Zimmern, P. E.; Reitzer, L.
10.1101/2024.08.13.607059 — microbiology — Posted on 2025-02-08
3911 Immune-neuroendocrine phenotypic expression changes through life in Coturnix japonica quails
Marozzi, A.; Correa, S. G.; Palme, R.; Cantarelli, V. I.; Ponzio, M. F.; Marin, R. H.; Nazar, F. N.
10.1101/2024.01.24.577005 — physiology — Posted on 2025-02-08
3912 Dynamic dysregulation of Tenascin-X/Tenascin-C balance controlled by Transforming Growth Factor-beta leads to tumor cell proliferation during pancreatic carcinogenesis
LIOT, S.; SCHMITTER, C.; MERCIER-GOUY, P.; EL KHOLTI, N.; BALAS, J.; PRIGENT, L.; AUBERT, A.; LETHIAS, C.; CHITTY, J. L.; KOCH, M.; FENOUIL, T.; Cox, T. R.; HENNINO, A.; HERVIEU, V.; RICARD-BLUM, S.; VALCOURT, U.; LAMBERT, E.
10.1101/2025.02.07.635757 — cancer biology — Posted on 2025-02-07
3913 Identifying Sex Differences in Lung Adenocarcinoma Using Multi-Omics Integrative Protein Signaling Networks
Chen, C.; Saha, E.; Fischer, J.; Ben Guebila, M.; Fanfani, V.; Shutta, K.; Padi, M.; Glass, K.; DeMeo, D.; Lopes-Ramos, C.; Quackenbush, J.
10.1101/2025.02.03.636354 — cancer biology — Posted on 2025-02-07
3916 Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage
Light-Maka, I.; Hermes, T. R.; Bianco, R. A.; Semerau, L.; Kosintsev, P.; Alekseeva, V.; Kim, D.; Hanage, W. P.; Herbig, A.; Jeong, C.; Warinner, C.; Key, F. M.
10.1101/2025.02.07.637078 — genetics — Posted on 2025-02-07
3917 Experimentally mimicking 30 years of Magallana gigas infections with the OsHV-1 virus reveals evolution through positive selection
Pelletier, C.; Faury, N.; Mege, M.; Degremont, L.; Hattinguais, M.; Vidal-Dupiol, J.; Chevignon, G.; Jacquot, M.; Morga, B.
10.1101/2025.02.07.637049 — evolutionary biology — Posted on 2025-02-07
3919 CD68+ Follicular Macrophages Harbor HIV Reservoirs in Human Lymph Node Tissues During Suppressive ART
Moodley, M.; Chasara, C.; Khaba, T.; Mahlobo, B.; Reddy, N.; Nxele, S.; Msipa, S.; Reddy, K.; Ngubane, T.; Jajbhay, I.; Pansegrouw, J.; Ndung'u, T.; Ndhlovu, Z. M.
10.1101/2025.02.03.636184 — immunology — Posted on 2025-02-07
3920 Dissection of retrosplenial cortex inputs: ubiquitous drive from anterior thalamus
Margetts-Smith, G.; Andrianova, L.; Kohli, S.; Randall, A. D.; Aggleton, J. P.; Witton, J.; Craig, M.
10.1101/2025.02.06.636939 — neuroscience — Posted on 2025-02-08
3922 Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories
Glass, M. R.; Matoba, N.; Beltran, A. A.; Patel, N. K.; Farah, T. M.; Eswar, K.; Bhargava, S.; Huang, K.; Curtin, I.; Ahmed, S.; Srivastava, M.; Drake, E.; Davis, L. T.; Yeturi, M.; Sun, K.; Love, M. I.; Simon, J. M.; St. John, T.; Marrus, N.; Pandey, J.; Estes, A.; Dager, S.; Schultz, R. T.; Botteron, K.; Evans, A.; Kim, S. H.; Styner, M.; McKinstry, R. C.; Collins, D. L.; Volk, H.; Benke, K.; Zwaigenbaum, L.; Hazlett, H.; Beltran, A. S.; Girault, J. B.; Shen, M. D.; Piven, J.; Stein, J. L.; the Infant Brain Imaging Study Network,
10.1101/2025.02.07.637106 — neuroscience — Posted on 2025-02-08
3924 Navigational Frames of Reference as Critical Regulators of Hippocampal Interneuron Coding Properties
Bott, J.-B.; Penazzi, L.; Al-Achkar, S.; Cho, M.; Bruno, R.; Gauthier Lafreniere, E.; Williams, S.
10.1101/2025.02.07.637101 — neuroscience — Posted on 2025-02-08
3928 Principled PCA separates signal from noise in omics count data
Stanley, J. S.; Yang, J.; Li, R.; Lindenbaum, O.; Kobak, D.; Landa, B.; Kluger, Y.
10.1101/2025.02.03.636129 — bioinformatics — Posted on 2025-02-07
3932 Unraveling the inbreeding depression patterns in a self-pollinated eucalyptus population
Ferreira, F. M.; Vieira-Netto, J. A.; Melchert, G. F.; Benatti, T. R.; Matos, J. V.; Muniz, F. R.; Brum, I. B.; Nascimento, A. V.; Bhering, L. L.; Dias, K. O.; Tambarussi, E. V.
10.1101/2025.02.03.636226 — genomics — Posted on 2025-02-07
3933 The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
Bigot, J.; Legendre, R.; Hamroune, J.; Jacques, S.; Le Gars, M.; Guillot, L.; Corvol, H.; Hennequin, C.; Guitard, J.; Coppee, J.-Y.; Balloy, V.; Chica, C.
10.1101/2025.02.03.636250 — genetics — Posted on 2025-02-07
3937 Sensory neurons shape macrophage identity via TGF-β signalling
Kolter, J.; Doering, C.-L.; Baasch, S.; Alsumati, R.; Mansoori Moghadam, Z.; Gres, V.; Lohrmann, F.; da Silva, G. V. L.; Silva, E. A.; Buchegger, T.; Doumard, L.; Voisin, B.; Lachmann, N.; Kierdorf, K.; Flacher, V.; Henneke, P.
10.1101/2025.02.06.635770 — immunology — Posted on 2025-02-07
3938 CK2 directly controls CARD9 protein homeostasis
Kelly, A. M.; Merselis, L. C.; Causton, B.; Calder, O. K.; Chao, H.; Prack, M.; Stine, L. B.; Amako, Y.; Wang, T.; Yesilkanal, A. E.; Condon, K. J.; Pierce, M. O.; Watterson, S. H.; Guernon, J.; Anand, A.; Selvam, S.; Dagde, S.; Holzinger, E.; Piasecki, L.; Pemberton, T. A.; Fu, E.; Joint, M.; Sandt, H.; Singh, A. K.; Wang, T.; Cobb, D.; Ni, X.; Davies, G. H. M.; Corin, A. F.; Roy, S.; Wilson, S. C.
10.1101/2025.02.03.636288 — immunology — Posted on 2025-02-07
3940 Robustness of high-throughput prediction of leaf ecophysiological traits using near infra-red spectroscopy and poro-fluorometry
Coindre, E.; Boulord, R.; Chir, L.; Freitas, V.; Ryckewaert, M.; Laisne, T.; Bouckenooghe, V.; Lis, M.; Cabrera-Bosquet, L.; Doligez, A.; Simonneau, T.; Pallas, B.; Coupel-Ledru, A.; Segura, V.
10.1101/2025.02.07.636194 — plant biology — Posted on 2025-02-07
3941 AI-based prediction of herbarium sequencing success across the plant tree of life
Ranjbaran, Y.; Maurin, O.; Canadelli, E.; Morosinotto, T.; Weech, M.-H.; Kersey, P.; Antonelli, A.; Baker, W. J.; Sales, G. J.; Dal Grande, F.
10.1101/2025.02.03.636220 — plant biology — Posted on 2025-02-07
3944 Hypoalbuminemia Increases Fibrin Clot Density and Impairs Fibrinolysis
Waller, A. P.; Wolfgang, K. J.; Stevenson, Z. S.; Holle, L. A.; Wolberg, A. S.; Kerlin, B. A.
10.1101/2025.02.03.635731 — physiology — Posted on 2025-02-07
3947 Accurate Protein Dynamic Conformational Ensembles: Combining AlphaFold, MD and Amide 15N(1H) NMR Relaxation.
Lesovoy, D.; Roshchin, K.; Sala, B. M.; Sandalova, T.; Achour, A.; Agback, T.; Orekhov, V.; Agback, P.
10.1101/2025.02.07.637034 — molecular biology — Posted on 2025-02-07
3948 Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years.
de Zwaan, R.; de Vries, G.; Ubbelohde, E.; Mulder, A.; Kamst-van Agterveld, M.; Rebel, K.; Kautz, S.; Kremer, K.; Anthony, R.; van Soolingen, D.
10.1101/2025.02.07.637016 — microbiology — Posted on 2025-02-07
3950 Stable states in an unstable landscape: microbial resistance at the front line of climate change
Cronin, D. R.; Holland-Moritz, H.; Smith, D.; Aroney, S. T. N.; Hodgkins, S.; Borton, M.; Li, Y.-F.; Healy, K.; IsoGenie Field & Analytic Teams 2010-2017, ; EMERGE Institute Coordinators, ; Tfaily, M. M.; Crill, P. M.; McCalley, C.; Wrighton, K.; Varner, R. K.; Tyson, G. W.; Woodcroft, B.; Bagby, S. C.; Ernakovich, J.; Rich, V. I.
10.1101/2025.02.07.636677 — microbiology — Posted on 2025-02-07
3951 Leishmania tarentolae and Leishmania infantum in geckos from Mallorca Island, Spain
Marti-Carreras, J.; Espunyes, J.; Carrera-Faja, L.; Pasetto, C.; Alcover Amengual, M. M.; Chavez-Fisa, S.; Carrasco, M.; Roura, X.; Francino, O.; Ferrer, L.
10.1101/2025.02.06.636881 — microbiology — Posted on 2025-02-07
3952 The offensive role of the Bacillus extracellular matrix in driving metabolite-mediated dialogue and adaptive strategies with pathogenic fungi
Perez Lorente, A. I.; Molina-Santiago, C.; Vela-Corcia, D.; Stincone, P.; Hierrezuelo, J.; Grife, M.; Pakkir Shah, A. K.; de Vicente, A.; Petras, D.; Romero, D.
10.1101/2025.02.06.636830 — microbiology — Posted on 2025-02-07
3953 Diversity, abundance, and biogeography of CO2 fixing microorganisms in peatlands
Le Geay, M.; Mayers, K.; Sytiuk, A.; Dorrepaal, E.; Kuttim, M.; Lamentowicz, M.; Tuittila, E.-S.; Lauga, B.; Jassey, V. E.
10.1101/2025.02.07.637021 — microbiology — Posted on 2025-02-07
3957 Inverse Agonism of the FFA4 free fatty acid receptor controls both adipogenesis and mature adipocyte function
Hudson, B. D.; Alshammari, W. S.; Duncan, E. M.; Vita, L.; Kenawy, M.; Dibnah, B.; Wabitsch, M.; Gould, G. W.
10.1101/2025.02.02.636098 — pharmacology and toxicology — Posted on 2025-02-07
3958 Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway
de la Torre Medina, J. R.; Joshi, U.; Sonowal, H.; Kuang, Y.; Ren, T.; Chen, D.-h.; Tharuka, M. D. N.; Nguyen-Ta, K.; Gros, H.; Mikulski, Z.; Chen, Y.; White, R. R.
10.1101/2025.02.06.636475 — cancer biology — Posted on 2025-02-07
3959 RAS pathway activation drives clonal selection and monocytic differentiation in FLT3 and BCL2 inhibitor resistance
Kennedy, V. E.; Peretz, C. A. C.; Walia, A.; Chyla, B.; Sun, Y.; Hill, J.; Tran, E.; Koh, A.; Ferng, T.; Pintar, S.; Jones, M.; Popescu, B.; Murad, N.; Roy, R.; Olshen, A.; Joshi, S.; Traer, E.; Dail, M.; Hamidi, H.; Altman, J.; Daver, N.; Levis, M.; McCloskey, J.; Perl, A.; Smith, C. C.
10.1101/2025.02.02.636108 — cancer biology — Posted on 2025-02-07
3960 Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase
Herrera-Asmat, O.; Tong, A. B.; Lin, W.; Kong, T.; Del Valle, J. R.; Guerra, D. G.; Ebright, Y. W.; Ebridght, R.; Bustamante, C.
10.1101/2025.02.07.637008 — biophysics — Posted on 2025-02-07
3961 Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites.
Rivero, M.; Pacheco-Garcia, J. L.; Vankova, P.; Loginov, D. S.; Quereda-Moraleda, I.; Martin-Garcia, J. M.; Man, P. M.; Medina, M.; Pey, A. l.
10.1101/2025.02.02.636097 — biophysics — Posted on 2025-02-07
3963 scBSP: A fast and accurate tool for identifying spatially variable features from high-resolution spatial omics data
Li, J.; Raina, M.; Wang, Y.; Xu, C.; Su, L.; Guo, Q.; Ferreira, R. M.; Eadon, M. T.; Ma, Q.; Wang, J.; Xu, D.
10.1101/2025.02.02.636138 — bioinformatics — Posted on 2025-02-07
3966 BTK Autoinhibition Analyzed by High-Throughput SH2 Domain Swaps
Eisen, T. J.; Ghaffari-Kashani, S.; Hung, C.-L.; Groves, J. T.; Kuriyan, J.
10.1101/2025.02.06.636897 — biochemistry — Posted on 2025-02-07
3967 Kinetic characterization of three human DExD/H-box RNA helicases
Li, F.; Chan, U. H.; Perez, J. G.; Zeng, H.; Chau, I.; Li, Y.; Seitova, A.; Halabelian, L.
10.1101/2025.02.07.637080 — biochemistry — Posted on 2025-02-07
3970 A silicon rhodamine-fused glibenclamide to label and detect malaria-infected red blood cells
Bastl, C.; Close, C.; Holtz, I.; Gatin-Fraudet, B.; Eis, M.; Werum, M.; Konrad, S.; Rossmann, K.; Huhn, C.; Ghosh, S.; Ast, J.; Roosen, D. A.; Lehmann, M.; Haucke, V.; Reymond, L.; Hodson, D. J.; Tinnefeld, P.; Johnsson, K.; Glembockyte, V.; Kilian, N.; Broichhagen, J.
10.1101/2025.02.07.637098 — biochemistry — Posted on 2025-02-07
3972 Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked
Ast, A.; Roth, L.; Brusendorf, L.; Schindler, F.; Ammar, O.; Berberich, S.; Edel, J.; Bonsor, M.; Georgii, E.; Haenig, C.; Langnick, C.; Ivanov, A.; Beule, D.; Piraud, M.; Kunz, S.; Popp, O.; Mertins, P.; Petzoldt, A. G.; Wanker, E. E.
10.1101/2025.02.06.636778 — molecular biology — Posted on 2025-02-07
3973 RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters
Wiechers, H.; Williams, C. J.; Eltzner, B.; Hoppe, F.; Prisant, M. G.; Chen, V. B.; Miller, E.; Mardia, K. V.; Richardson, J. S.; Huckemann, S. F.
10.1101/2025.02.06.636803 — molecular biology — Posted on 2025-02-07
3975 The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor
Sozanska, N.; Klepka, B. P.; Niedzwiecka, A.; Zukowa, L.; Dadlez, M.; Greb-Markiewicz, B.; Ozyhar, A.; Tarczewska, A.
10.1101/2025.02.06.636797 — molecular biology — Posted on 2025-02-07
3980 Peritoneal cavity-derived GATA6+ macrophages inhibit fibrosis through IL33 in endometrium
Yin, L.; Li, J.; dong, y.; wang, j.; wang, x.; li, y.; Hu, Y.; Hou, Y.; Zhao, G.
10.1101/2025.02.02.636170 — immunology — Posted on 2025-02-07
3982 Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis
Antypas, H.; Schmidtchen, V.; Staiger, W. I.; Li, Y.; Tan, R. J. W.; Ng, K. K. F.; Neo, C. J. Y.; Radhesh, S. M.; Tanoto, F. R.; da Silva, R. A. G.; Colomer Winter, C.; Manzano, C.; Wong, J. J.; Pethe, K.; Hasse, B.; Brugger, S. D.; Wong, S. L.; Van Tyne, D.; Zinkernagel, A. S.; Kline, K. A.
10.1101/2025.02.07.636843 — microbiology — Posted on 2025-02-07
3986 Modeling of hepatitis B virus infection spread in primary human hepatocytes
Shi, Z.; Tsuge, M.; Collier, N.; Takeuchi, Y.; Uchida, T.; Rutter, C.; Teraoka, Y.; Uprichard, S. L.; Ishida, Y.; Tateno, C.; Ozik, J.; Dahari, H.; Chayama, K.
10.1101/2025.02.05.636596 — systems biology — Posted on 2025-02-07
3987 Molecular investigation of Rlm3 from rapeseed as a broad-spectrum resistance gene against fungal pathogens producing structurally conserved effectors
Talbi, N.; Pakzad, S.; Blaise, F.; Ollivier, B.; Rouxel, T.; Balesdent, M.-H.; Blondeau, K.; Lazar, N.; Van Tilbeurgh, H.; Mesarich, C. H.; Fudal, I.
10.1101/2025.02.03.635517 — plant biology — Posted on 2025-02-07
3990 Factors Influencing Phenomic Prediction: A Case Study on a Large Sorghum BCNAM Population
Bienvenu, C.; Garin, V.; Salas, N.; Thera, K.; Tekete, M. L.; Sarathjith, M. C.; Diallo, C.; Berger, A.; Catalayud, C.; De Bellis, F.; Rami, J. F.; Vaksmann, M.; Segura, V.; Pot, D.; De Verdal, H.
10.1101/2025.02.04.636400 — genomics — Posted on 2025-02-07
3991 Germline sequence variation within the ribosomal DNA is associated with human complex traits
Rodriguez-Algarra, F.; Cooper, M.; Mardakheh, F. K.; Evans, D. M.; Rakyan, V. K.
10.1101/2025.02.06.635840 — genetics — Posted on 2025-02-07
3992 A typology of Australian terrestrial bird communities
Maron, M.; Kutt, A.; Maisey, A.; Burbidge, A.; Freeman, A.; Bennett, A. F.; Haslem, A.; Reside, A. E.; Tulloch, A.; Hansen, B.; Palmer, B.; Melton, C. B.; Teixeira, D.; Watson, D.; Robinson, D.; Vanderduys, E.; Rainsford, F.; Maurer, G.; Fraser, H.; Mayfield, H. J.; Mihailou, H.; Possingham, H.; Humphrey, J.; Radford, J.; Watson, J.; Simmonds, J. S.; Mills-Anderson, J.; Reid, J.; Indraswari, K.; Selwood, K.; Clarke, M.; Gibson, M.; Leseberg, N. P.; Jackett, N.; McDonald, P.; Spindler, R.; Loyn, R.; Noske, R.; Davis, R.; Clarke, R. H.; Verdon, S.; Eyre, T.
10.1101/2025.02.03.635991 — ecology — Posted on 2025-02-07
3993 Microbiota Dynamics in Lionfish (Pterois): Insights into Invasion and Establishment in the Mediterranean Sea
Meron, D.; Lalzar, M.; Rothman, S. B.-S.; Kroin, Y.; Kaufman, E.; Kitson-Walters, K.; Zvi-Kedem, T.; Shemesh, E.; Tsadok, R.; Nativ, H.; Einbinder, S.; Tchernov, D.
10.1101/2025.02.03.635474 — ecology — Posted on 2025-02-07
3994 Liver transplant rejection features memory cell priming, spatially differentiated networks and novel drug targets.
Ningappa, M.; Ashokkumar, C.; Murali, D.; Rajasundaram, D.; Higgs, B. W.; McDonald, W.; Schmitt, L.; Zhang, L.; Chattopadhyay, A.; kane, m.; Murphy, P.; Soltys, K.; Mazariegos, G.; Gupta, S.; Kar, U.; Billiar, T.; Zeevi, A.; Xu, Q.; Reyes-Mugica, M.; Subramaniam, S.; Sindhi, R.
10.1101/2025.02.04.635308 — immunology — Posted on 2025-02-07
3995 The MicroRNA pathway regulates obligatory aestivation in a flea beetle
Guney, G.; Schmitt, K.; Zicola, J.; Toprak, U.; Rostas, M.; Scholten, S.; Cedden, D.
10.1101/2025.02.05.631883 — zoology — Posted on 2025-02-07
3997 GPR182 is a lipoprotein receptor for dietary fat absorption
Sun, Z.; Torphy, R. J.; Miller, E. N.; Darehshouri, A.; Vigil, I.; Terai, T.; Eck, E.; Sun, Y.; Guo, Y.; Yee, E. J.; Hu, J.; Kedl, R. M.; Lasda, E. L.; Hesselberth, J. R.; MacLean, P.; Bruce, K. D.; Randolph, G. J.; Schulick, R. D.; Zhu, Y.
10.1101/2025.02.03.634329 — physiology — Posted on 2025-02-07
3998 Virtual World Coupling with Photosynthesis Evaluation for Synthetic Data Production
Baker, D. N.; Giraud, M.; Goebbert, J. H.; Scharr, H.; Riedel, M.; Hvannberg, E. T.; Schnepf, A.
10.1101/2025.02.06.633870 — bioinformatics — Posted on 2025-02-07
4001 Accelerating Antibody Development: Sequence and Structure-Based Models for Predicting Developability Properties through Size Exclusion Chromatography
Abeer, A. N. M. N.; Boroumand, M.; Sermadiras, I.; Caldwell, J. G.; Stanev, V.; Mody, N.; Kaplan, G.; Savery, J.; Croasdale-Wood, R.; Pouryahya, M.
10.1101/2025.02.02.636157 — bioinformatics — Posted on 2025-02-07
4007 Free-Form Microfluidic Microneedle Array Patches
Coates, I. A.; Driskill, M. M.; Rajesh, N. U.; Lipkowitz, G.; Ilyin, D.; Xu, Y.; Dulay, M. T.; Jacobson, G. B.; Perry, J. L.; Tian, S.; DeSimone, J. M.
10.1101/2025.02.03.635973 — bioengineering — Posted on 2025-02-07
4008 Integrated detection and quantification of aberrant transcripts with novel splicing events
Agrawal, I.; Lim, Y. S.; Sanford, E. M.; Yun, W.; Ling, S.-C.; Tucker-Kellogg, G.
10.1101/2025.02.02.635191 — genomics — Posted on 2025-02-07
4011 Environmental impact of integrating decentralized urine treatment in the urban wastewater management system: A comparative life cycle assessment
Appiah-Twum, H.; Van Winckel, T.; Santolin, J.; De Paepe, J.; Hellweg, S.; Larsen, T. A.; Udert, K. M.; Vlaeminck, S. E.; Spiller, M.
10.1101/2025.02.02.636102 — ecology — Posted on 2025-02-07
4014 The Winner Takes It All: a single genotype of Kalanchoe xhoughtonii is a global invader
Pascual-Diaz, J. P.; Besoli, N.; Lopez-Pujol, J.; Nualart, N.; Perez-Lorenzo, I.; Shtein, R.; Valenzuela, L.; Vitales, D.; Garcia, S.
10.1101/2025.02.03.636197 — plant biology — Posted on 2025-02-07
4015 mRNA stability factor HuR promotes immune evasion in pancreatic ductal adenocarcinoma
Guo, Y.; Finan, J. M.; Bartlett, A. Q.; Sivagnanam, S.; Blise, K. E.; Kirchberger, N.; Betre, K.; Hawthorne, K.; Chen, C.; Grossberg, A.; Xia, Z.; Coussens, L. M.; Sears, R. C.; Brody, J. R.; Eil, R.
10.1101/2025.02.07.632847 — cancer biology — Posted on 2025-02-07
4019 Kinesin-12 KLP-18 contributes to the kinetochore-microtubule poleward flux during the metaphase of C. elegans one-cell embryo.
Soler, N.; Da Silva, M.; Tascon, C.; Chesneau, L.; Foliard, P.; Bouvrais, H.; Pastezeur, S.; Le Marrec, L.; Pecreaux, J.
10.1101/2022.11.07.515476 — cell biology — Posted on 2025-02-07
4020 Unprecedented Number of Recurrent Mutations Drive the Rapid Evolution of Pesticide Resistance in a Notorious Pest
Cao, L.-J.; Chen, J.-C.; Thai, J.; Schmidt, T.; Ffrench-Constant, R.; Zhang, L.-X.; Yang, Y.; Yuan, M.-C.; Zhang, J.-Y.; Zhang, X.-Y.; Yang, Q.; Gong, Y.-J.; Li, H.; Chen, X.; Hoffmann, A.; Wei, S.-J.
10.1101/2025.02.06.636798 — evolutionary biology — Posted on 2025-02-07
4022 Antagonistic kinesin-14s within a single chromosomal drive haplotype
Brady, M. J.; Gupta, A.; Gent, J. I.; Swentowsky, K. W.; Unckless, R. L.; Dawe, R. K.
10.1101/2025.02.05.636711 — evolutionary biology — Posted on 2025-02-07
4023 Museum genomics reveals temporal genetic stasis and global genetic diversity in Arabidopsis thaliana
Lopez, L.; Lang, P. L. M.; Marciniak, S.; Kistler, L.; Latorre, S. M.; Haile, A.; Vasquez Cerda, E.; Gamba, D.; Xu, Y.; Woods, P.; Yifru, M.; Kerby, J.; McKay, J. K.; Oakley, C. G.; Agren, J.; Wondimu, T.; Bulafu, C.; Perry, G. H.; Burbano, H. A.; Lasky, J. R.
10.1101/2025.02.06.636844 — evolutionary biology — Posted on 2025-02-07
4024 Systems acclimation to osmotic stress in zygnematophyte cells
Zegers, J. M.; Pfeifer, L.; Darienko, T.; Schmitt, K.; Dorsch, C. A.; Kunz, C. F.; Braus, G. H.; Classen, B.; Valerius, O.; de Vries, J.
10.1101/2025.02.06.636795 — evolutionary biology — Posted on 2025-02-07
4026 Influence of past climate changes and human-mediated introduction on patterns of genetic diversity distribution of the Papuan nutmeg (Myristica argentea) Warb.
Kusuma, J.; Milaba, A. C.; Paramitha, A.; Malaval, V.; Sari, M. N.; Nurhuda, C.; Couderc, M.; Scarcelli, N.; Watts, J.; Duminil, J.
10.1101/2025.02.05.636754 — evolutionary biology — Posted on 2025-02-07
4028 Bat things come in threes: within-host dynamics of herpesvirus triple infection in bats
Aguillon, S.; Turpin, M.; Le Minter, G.; Lebarbenchon, C.; Hoarau, A. O. G.; Mavingui, P.; Dietrich, M.
10.1101/2025.02.05.636680 — evolutionary biology — Posted on 2025-02-07
4029 Avid lysosomal acidification in fibroblasts of the Mediterranean mouse Mus spretus
Sui, M.; Teh, J.; Fort, K. A.; Shaw, D. E.; Sudmant, P. H.; Koide, T.; Good, J.; Vazquez, J. M.; Brem, R. B.
10.1101/2025.02.05.636718 — evolutionary biology — Posted on 2025-02-07
4030 The receptor-like kinases BIR1 and BIR3 modulate antiviral resistance by different mechanisms
Robinson, C.; Guzman-Benito, I.; Sede, A. R.; Elvira-Gonzalez, L.; Hua, C.; Ciska, M.; Nurnberger, T.; Heinlein, M.; Llave, C.
10.1101/2025.01.24.634664 — plant biology — Posted on 2025-02-07
4031 Controlled retrieval relies on directed interactions between semantic control regions and visual cortex: MEG evidence from oscillatory dynamics
Eisenhauer, S.; Zhang, M.; Krieger-Redwood, K.; Aveyard, R.; Jackson, R. L.; Cornelissen, P. L.; Smallwood, J.; Jefferies, E.
10.1101/2024.09.07.611827 — neuroscience — Posted on 2025-02-07
4036 Female fruit flies use social cues to make egg clustering decisions
Churchill, E. R.; Fowler, E. K.; Friend, L. A.; Archetti, M.; Yu, D. W.; Bourke, A. F. G.; Chapman, T.; Bretman, A.
10.1101/2024.07.03.600353 — animal behavior and cognition — Posted on 2025-02-07
4037 Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents
Langschied, F.; Leisegang, M. S.; Guenther, S.; Hahner, F.; Brandes, R. P.; Ebersberger, I.
10.1101/2024.12.05.627021 — genetics — Posted on 2025-02-07
4039 The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice
Huang, Y.; Bucevic, N.; Coves, C.; Felipe-Medina, N.; Marcet-Ortega, M.; Nikou, N.; Madrid-Sandin, C.; Lopez-Panades, M.; Buza, C.; Ferrer Miralles, N.; Iborra, A.; Pujol, A.; Pendas, A. M.; Roig, I.
10.1101/2024.02.06.579114 — cell biology — Posted on 2025-02-07
4045 Early intrinsic plasticity of ACC engram neurons defines memory formation and precision
Hadzibegovic, S.; Zhu, L.; Ginger, M.; De Sa, R.; Le Corf, K.; Costa, M. J.; Le Feuvre, Y.; Nicole, O.; Bontempi, B.; Frick, A.
10.1101/2024.09.13.612936 — neuroscience — Posted on 2025-02-07
4047 The WIPI homolog Atg18 binds to and tethers membranes containing phosphatidylinositol-3,4,5-triphosphate.
Noguera-Canas, F. L.; Diaz-Agustin, A.; Gavira, J. A.; Paredes, J. M.; Salto, R.; Orte, A.; Conejero-Lara, F.; Martin-Martinez, M.; Perez-Lara, F. A.
10.1101/2025.01.31.635529 — biophysics — Posted on 2025-02-07
4049 Under or Over? Tracing Complex DNA Structures with High-Resolution Atomic Force Microscopy
Holmes, E. P.; Gamill, M. C.; Provan, J. I.; Wiggins, L.; Ruskova, R.; Whittle, S.; Catley, T. E.; Main, K. H. S.; Shephard, N.; Bryant, H. E.; Gilhooly, N. S.; Gambus, A.; Racko, D.; Colloms, S. D.; Pyne, A. L. B.
10.1101/2024.06.28.601212 — biophysics — Posted on 2025-02-07
4051 Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease
Busarello, E.; Biancon, G.; Cimignolo, I.; Lauria, F.; Ibnat, Z.; Ramirez, C.; Tome, G.; Ciuffreda, M.; Bucciarelli, G.; Pilli, A.; Marino, S. M.; Bontempi, V.; Aass, K. R.; VanOudenhove, J. J.; Mione, M.; Standal, T.; Macchi, P.; Viero, G.; Halene, S.; Tebaldi, T.
10.1101/2024.03.08.584053 — bioinformatics — Posted on 2025-02-07
4052 TMVisDB: Annotation and 3D-visualization of transmembrane proteins
Olenyi, T.; Marquet, C.; Grekova, A.; Houri, L.; Heinzinger, M.; Dallago, C.; Rost, B.
10.1101/2024.11.22.624323 — bioinformatics — Posted on 2025-02-07
4054 Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons
Cuvertino, S.; Martirosian, E.; Cheng, P.; Garner, T.; Donaldson, I. J.; Jackson, A.; Stevens, A.; Sharrocks, A. D.; Kimber, S. J.; Banka, S.
10.1101/2025.02.06.636815 — genetics — Posted on 2025-02-07
4056 Impact of Enteric Neuronal Loss on Intestinal Cell Composition
Kakiailatu, N. J. M.; Zhang, W.; Kuil, L. E.; Windster, J. D.; Bindels, E.; Zink, J. T. M.; Vermeulen, M.; de Graaf, B. M.; Sahadew, D.; van den Bosch, T. P. P.; Huijgen, D.; Sloots, C. E. J.; Wijnen, R. M. H.; Hofstra, R. M. W.; de Pater, E.; Melotte, V.; Alves, M. M.
10.1101/2024.06.26.600730 — developmental biology — Posted on 2025-02-07
4057 MuSpAn: A Toolbox for Multiscale Spatial Analysis
Bull, J. A.; Moore, J. W.; Mulholland, E. J.; Leedham, S. J.; Byrne, H. M.
10.1101/2024.12.06.627195 — cell biology — Posted on 2025-02-07
4063 Binocular combination in the autonomic nervous system
Segala, F. G.; Bruno, A.; Martin, J. T.; Morsi, A. Y.; Wade, A. R.; Baker, D. H.
10.1101/2024.06.04.597314 — neuroscience — Posted on 2025-02-07
4066 AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
Elsheikh, A.; Driggers, C. M.; Truong, H. H.; Yang, Z.; Allen, J.; Henriksen, N.; Walczewska-Szewc, K.; Shyng, S.-L.
10.1101/2024.09.05.611490 — biochemistry — Posted on 2025-02-07
4068 Developing a model to implement marker-assisted selection for root-knot nematode resistance in common bean
Floriani, T. O.; Gama, H. C.; Moreno, B. M.; Costa, G. A. L.; Giordani, W.; Chiorato, A. F.; Bibiano, L.; Parker, T. A.; Camargo, L. E. A.; Vieira, M. L. C.; Garcia, A. A. F.
10.1101/2025.01.31.635933 — genetics — Posted on 2025-02-07
4072 DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication
Feng, F.; Chen, J.; Li, R.; Zhu, Y.; Ma, Y.; Wang, Z.; Wang, Y.; Gao, Z.; Yang, L.; Yu, Y.; Liu, Y.; Sun, Y.; Liao, Y.; Huang, X.; Zhang, Q.; Huang, Y.; Qiu, L.; Wu, J.; Zhao, J.; Liu, C.; Ding, Q.; Xie, Y.; Yuan, Z.; Hong, Y.; Zhang, P.; Sun, J.; Zhao, J.; Zhang, R.
10.1101/2025.02.04.636569 — microbiology — Posted on 2025-02-07
4073 Lipid hydrogen isotope compositions primarily reflect growth water in the model archaeon Sulfolobus acidocaldarius
Harris, C. M.; Kopf, S.; Rhim, J. H.; Cobban, A.; Elling, F. J.; Feng, X.; McFarlin, J.; Weber, Y.; Zhang, Y.; Zhou, A.; Batther, H.; Pearson, A.; Leavitt, W. D.
10.1101/2024.10.24.620110 — microbiology — Posted on 2025-02-07
4075 IGLV3-21-R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia
Fischer, C. S.; Stuecheli, S.; Chen, S.-S.; Nimmerfroh, J.; Schultheiss, C.; Widmer, C.; Heim, D.; Kasenda, B.; Passweg, J. R.; Kobold, S.; Egli, L.; Coianiz, N.; Chijioke, O.; Chiorazzi, N.; Follo, M.; Laubli, H.; Peipp, M.; Binder, M.
10.1101/2025.02.04.636461 — cancer biology — Posted on 2025-02-07
4076 Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age
Guo, X.; Sulaiman, M.; Neumann, A.; Zheng, S. C.; Cecil, C. A. M.; Teschendorff, A.; Heijmans, B.
10.1101/2025.02.02.636167 — bioinformatics — Posted on 2025-02-07
4077 Evolutionary trends in Bombella apis CRISPR-Cas systems
Ganote, C.; Caesar, L.; Rice, D. W.; Whitaker, R. J.; Newton, I. L. G.
10.1101/2025.02.05.636693 — genomics — Posted on 2025-02-07
4078 Genomic Insights into the Demographic History and Local Adaptation of Wild Boars Across Eurasia
Wang, Z.; Li, Z.; Huang, T.; Chen, J.; Xu, P.; Qiao, R.; Yin, H.; Song, C.; Zhang, D.; Liu, D.; Zhao, S.; Groenen, M.; Madsen, O.; Zhang, Y.; Bai, L.; Li, K.
10.1101/2025.02.05.636574 — evolutionary biology — Posted on 2025-02-07
4080 The role of toxin/antidote genes in the maintenance and evolution of accessory chromosomes in Fusarium
Sandell, L.; Forsythe, A.; Mirandola, A.; Jorayev, S.; Urquhart, A. S.; Granger Farbos, A.; Saupe, S. J.; Vogan, A. A.
10.1101/2025.02.05.636631 — evolutionary biology — Posted on 2025-02-07
4082 Bclaf1 biomolecular condensates protect nuclear PTK2 from ubiquitin-proteasome system promoting cardiomyocyte survival during oxidative stress
Aparecida Moretto, I.; Rodrigues, B. R. I.; Victor-Carvalho, P.; Carvalho, M. d. G. d. S.; Silva, M. C. d.; Valdivieso-Rivera, F. B.; Araujo, G. L. d.; Samogim, A. P.; Novais, L. B.; de Brito, I. R.; Reis-de-Oliveira, G.; Amaral, A. G.; Baratti, M. O.; Basei, F. L.; Geraldo, M. V.; Carvalho, P. C.; Santos, M. D. M.; Duran, R.; Sponton, C.; Kobarg, J.; Gozzo, F. C.; Carvalho, H. F.; Thomaz, A. A. d.; Santos, A. M. d.
10.1101/2025.02.04.636487 — cell biology — Posted on 2025-02-07
4083 Vibrio harveyi plasmids as drivers of virulence in barramundi (Lates calcarifer)?
Sullivan, R. R.; Becker, J. A.; Zadoks, R.; Venturini, C.; Esteves, A.; Benedict, S.; Fornarino, D.; Andrews, H.; Okoh, G.; Bhardwaj, V.; Sistrom, M.; Westman, M.; Nguyen, P. N.; Samsing, F.
10.1101/2025.02.05.636614 — microbiology — Posted on 2025-02-07
4084 Dual inhibition of lactate transporters MCT1 and MCT4 in pancreatic neuroendocrine tumors targets metabolic heterogeneity and functional redundancy
Bräutigam, K.; Straub, J.; Bihi, A. K.; Maire, R.; Avanthay, S.; Filipova, K.; Andreasi, V.; Battistella, A.; Kirchner, P. P.; Dettmer, M. S.; Schrader, J.; Schiavo Lena, M.; Partelli, S.; Falconi, M.; Marinoni, I.; Sadowski, M. C.; Perren, A.
10.1101/2025.01.31.635625 — cancer biology — Posted on 2025-02-07
4085 Progressive changes in functional connectivity between thalamic nuclei and cortical networks across learning
Jarrett, C. E.; Zwosta, K.; Wang, X.; Wolfensteller, U.; Iglesias, J. E.; von Kriegstein, K.; Ruge, H.
10.1101/2024.08.26.609333 — neuroscience — Posted on 2025-02-06
4088 Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons
Cuvertino, S.; Martirosian, E.; Cheng, P.; Garner, T.; Donaldson, I. J.; Jackson, A.; Stevens, A.; Sharrocks, A. D.; Kimber, S. J.; Banka, S.
10.1101/2025.02.06.636815 — genetics — Posted on 2025-02-06
4094 Down syndrome with Alzheimers disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis
Thorwald, M. A.; Godoy-Lugo, J. A.; Kerstiens, E.; Garcia, G.; Kim, M.; Shemtov, S. J.; Silva, J.; Durra, S.; O'Day, P.; Mack, W. J.; Hiniker, A.; Vermulst, M.; Benayoun, B. A.; Higuchi-Sanabria, R.; Forman, H. J.; Head, E.; Finch, C. E.
10.1101/2025.02.05.636731 — neuroscience — Posted on 2025-02-06
4095 Noradrenaline and Acetylcholine shape Functional Connectivity organization of NREM substages: an empirical and simulation study
Lehue, F.; Coronel-Oliveros, C.; Medel, V.; Liebe, T.; Kaufmann, J.; Orellana, S.; Becerra, D.; Tagliazucchi, E.; Orio, P.
10.1101/2025.02.06.636812 — neuroscience — Posted on 2025-02-06
4096 Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity
Dalton, C.; Mojsilovic-Petrovic, J.; Safren, N.; Snoznik, C.; Gebis, K. K.; Wang, Y.-Z.; Lamitina, T.; Savas, J.; Kalb, R.
10.1101/2025.02.06.636899 — neuroscience — Posted on 2025-02-06
4099 A scotophobic response characterised by body contraction and ciliary arrest in Acropora coral larvae
Brodrick, E. A.; Jokura, K.; Craggs, J.; Poon, R.; Laeverenz-Schlogelhofer, H.; Wan, K. Y.; Jekely, G.
10.1101/2025.02.06.636794 — neuroscience — Posted on 2025-02-06
4100 A wireless, 60-channel, AI-enabled neurostimulation platform
Rizzuto, D. S.; Hu, Z.; Utin, D.; Kahn, J.; Ho, C.; Smiles, A.; Gross, R. E.; Lega, B. C.; Das, S. R.; Kahana, M. J.
10.1101/2025.02.04.635298 — neuroscience — Posted on 2025-02-06
4102 Striatal and cerebellar interactions during reward-based motor performance
Lee, J. L.; Casamento-Moran, A.; Bastian, A. J.; Cullen, K. E.; Chib, V. S.
10.1101/2025.02.06.636434 — neuroscience — Posted on 2025-02-06
4105 De novo identification of universal cell mechanics gene signatures
Urbanska, M.; Ge, Y.; Winzi, M.; Abuhattum, S.; Ali, S. S.; Herbig, M.; Kraeter, M.; Toepfner, N.; Durgan, J.; Florey, O.; Dori, M.; Calegari, F.; Lolo, F.-N.; del Pozo, M. A.; Taubenberger, A.; Cannistraci, C. V.; Guck, J.
10.1101/2021.04.26.441418 — biophysics — Posted on 2025-02-06
4107 Sources of non-uniform coverage in short-read RNA-Seq data
Brooks, T. G.; Lahens, N. F.; Mrcela, A.; Yang, J.; Purohit, S.; Naik, A.; Ricciotti, E.; Sengupta, S.; Choi, P.; Grant, G. R.
10.1101/2025.01.30.634337 — bioinformatics — Posted on 2025-02-06
4111 Secretory leukocyte protease inhibitor influences periarticular joint inflammation in B. burgdorferi-infected mice
Yu, Q.; Tang, X.; Hart, T.; Homer, R.; Belperron, A. A.; Bockenstedt, L.; Ring, A.; Nakamura, A.; Fikrig, E.
10.1101/2024.11.24.625079 — microbiology — Posted on 2025-02-06
4112 Gamma-burst cortical activity in awake behaving macaques
Acland, B. T.; Palanca, B. J. A.; Bijsterbosch, J. D.; Snyder, L. H.
10.1101/2023.09.26.559594 — neuroscience — Posted on 2025-02-06
4113 A geometric shape regularity effect in the human brain
Sable-Meyer, M.; Benjamin, L.; Watkins, C. P.; He, C.; Pajot, M.; Morfoisse, T.; Al Roumi, F.; Dehaene, S.
10.1101/2024.03.13.584141 — neuroscience — Posted on 2025-02-06
4114 Synaptic Targets of Circadian Clock Neurons Influence Core Clock Parameters
Scholz-Carlson, E.; Iyer, A. R.; Nern, A.; Ewer, J.; Fernandez, M. P.
10.1101/2025.01.30.635801 — neuroscience — Posted on 2025-02-06
4115 Alcohol drinking is associated with greater calcium activity in mouse central amygdala dynorphin-expressing neurons
Lebonville, C.; Rinker, J. A.; O'Hara, K.; McMahan, C.; Hoffman, M.; Becker, H.; Mulholland, P. J.
10.1101/2024.02.18.580880 — neuroscience — Posted on 2025-02-06
4118 Resting state brain network segregation is associated with walking speed and working memory in older adults
Sato, S. D.; Shah, V. A.; Fettrow, T.; Hall, K. G.; Tays, G. D.; Cenko, E.; Roy, A.; Clark, D. J.; Ferris, D. P.; Hass, C. J.; Manini, T. M.; Seidler, R. D.
10.1101/2024.05.07.592861 — neuroscience — Posted on 2025-02-06
4119 DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci
Rambarack, N.; Fodder, K.; Murthy, M.; Toomey, C.; de Silva, R.; Heutink, P.; Humphrey, J.; Raj, T.; Lashley, T.; Bettencourt, C.
10.1101/2025.01.21.634065 — neuroscience — Posted on 2025-02-06
4122 Analysis-ready VCF at Biobank scale using Zarr
Czech, E. A.; Millar, T. R.; Tyler, W.; White, T. E.; Elsworth, B.; Guez, J.; Hancox, J.; Jeffery, B.; Karczewski, K.; Miles, A.; Tallman, S.; Unneberg, P.; Wojdyla, R.; Zabad, S.; Hammerbacher, J.; Kelleher, J.
10.1101/2024.06.11.598241 — bioinformatics — Posted on 2025-02-06
4124 How do egocentric boundary cells depend upon the coordinate system of environmental features?
Hasselmo, M. E.; LaChance, P. A.; Robinson, J. C.; Malmberg, S. L.; Patel, M.; Gross, E.; Everett, D. E.; Sankaranarayanan, S.; Fang, J.
10.1101/2025.02.03.636060 — neuroscience — Posted on 2025-02-06
4125 Atypical plume-like events drive glutamate accumulation in metabolic stress conditions
Ziebarth, T.; Pape, N.; Nelson, J. S. E.; van Alphen, F. I. M.; Kalia, M.; Meijer, H. G. E.; Rose, C. R.; Reiner, A.
10.1101/2025.02.05.636645 — neuroscience — Posted on 2025-02-06
4126 Novel neurofilament light (Nefl) E397K mouse models of Charcot-Marie-Tooth type 2E (CMT2E) present early and chronic axonal neuropathy
Perez-Lopez, D. O.; Shively, A. O.; Torres, F. J. L.; Abu-Salah, M. T.; Garcia, M. L.; Arnold, W. D.; Lorson, M. A.; Lorson, C. L.
10.1101/2025.02.02.636117 — neuroscience — Posted on 2025-02-06
4127 Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.
Fuini, E.; Chang, A.; Ortiz, R.; Nasseef, T.; Edwards, J.; Latta, M.; Gonzales, E.; Woodward, T.; Bradshaw, H.; Axe, B.; Maheswari, A.; Cavallaro, N.; Kulkarni, P.; Ferris, C.
10.1101/2025.02.01.636078 — neuroscience — Posted on 2025-02-06
4130 Loss of white matter tracts and persistent microglial activation in the chronic phase of ischemic stroke in female rats and the effect of miR-20a-3p treatment
Sampath, D.; Zardeneta, M. E.; Akbari, Z.; Singer, J.; Gopalakrishnan, B.; Hurst, D. A.; Villarreal, M.; McDaniel, E. A.; Noarbe, B. P.; Obenaus, A.; Sohrabji, F.
10.1101/2025.02.01.636074 — neuroscience — Posted on 2025-02-06
4134 Neuro-behavioral impact of Tourette-related striatal disinhibition in rats
Loayza, J.; Taylor, C.; Renstrom, J.; Allen, R. G.; Jackson, S. R.; Bast, T.
10.1101/2025.02.02.636049 — neuroscience — Posted on 2025-02-06
4136 Cerebral blood perfusion across biological systems and the human lifespan
Farahani, A.; Liu, Z.-Q.; Ceballos, E. G.; Hansen, J. Y.; Wennberg, K.; Zeighami, Y.; Dadar, M.; Gauthier, C. J.; Dagher, A.; Misic, B.
10.1101/2025.02.05.636674 — neuroscience — Posted on 2025-02-06
4137 Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans
Maslarova, A.; Shin, J.; Navas-Olive, A.; Voroslakos, M.; Hamer, H.; Doerfler, A.; Henin, S.; Buzsaki, G.; Liu, A.
10.1101/2025.02.06.636758 — neuroscience — Posted on 2025-02-06
4140 Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia
Wilson, A. M.; Jacobs, M. M.; Lambert, T. Y.; Valada, A.; Meloni, G.; Gilmore, E.; Murray, J.; Morgello, S.; Akbarian, S.
10.1101/2025.02.05.636667 — genomics — Posted on 2025-02-06
4141 Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes
Johnson, R. M.; Breban, M. I.; Nolan, B. L.; Sodeinde, A.; Ott, I. M.; Ross, P. A.; Gu, X.; Grubaugh, N. D.; Perkins, T. A.; Brackney, D. E.; Vogels, C. B. F.
10.1101/2025.02.06.636928 — microbiology — Posted on 2025-02-06
4142 Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI
Jansen, J.; Kimbler, A.; Drayson, O.; Lanz, B.; Mosso, J.; Grilj, V.; Petit, B.; Franco-Perez, J.; Simon, A.; Limoli, C. L.; Marie-catherine, V.; Stark, C.; Ballesteros Zebadua, P.
10.1101/2025.02.01.636061 — neuroscience — Posted on 2025-02-06
4143 The effects of reliable social feedback on language learning: insights from EEG and pupillometry
Zappa, A.; Osokina, P.; Cerda-Company, X.; Cucurell, D.; Mateu, M.; Rodriguez-Fornells, A.
10.1101/2025.02.04.636399 — neuroscience — Posted on 2025-02-06
4145 The role of human intraparietal sulcus in evidence accumulation revealed by EEG and model-informed fMRI
Wongtrakun, J.; Zhou, S.-H.; O'Connell, R. G.; Chong, T. T.-J.; Bellgrove, M. A.; Coxon, J. P.
10.1101/2025.02.05.636628 — neuroscience — Posted on 2025-02-06
4147 THE EFFECT OF SERTRALINE AND VOLUNTARY EXERCISE DURING PREGNANCY ON LITTER CHARACTERISTICS AND POSTNATAL AFFECTIVE BEHAVIOUR IN RAT DAMS
Jarbou, N. S.; Mairinger, O.; Kulen, E.; Mushahwar, L.; Walpole, S.; Matthews, J.; Maksour, S.; Weston-Green, K.; Dottori, M.; Newell, K. A.
10.1101/2025.02.02.636079 — neuroscience — Posted on 2025-02-06
4149 Psilocybin as a Treatment for Repetitive Mild Head Injury: Evidence from Neuroradiology and Molecular Biology
Brengel, E. K.; Axe, B.; Maheswari, A.; Abeer, M. I.; Ortiz, R. J.; Woodward, T. J.; Walhof, R.; Utama, R.; Sawada, C.; Balaji, S.; Kulkarni, P. P.; Bradshaw, H. B.; Gitcho, M. A.; Ferris, C. F.
10.1101/2025.02.03.636248 — neuroscience — Posted on 2025-02-06
4150 Identifying JNK-regulated phosphoproteome markers of anxiety-like behaviour in mouse hippocampus
Hong, Y.; Flinkman, D.; Deshpande, P.; Fagerholm, V.; Varidaki, A.; Heemeryck, P.; Sourander, C.; JAmes, P.; Coffey, E.
10.1101/2025.02.06.636849 — neuroscience — Posted on 2025-02-06
4151 Network Biomarkers of Alzheimer's Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse Models
Bridgeford, E. W.; Chung, J.; Anderson, R. J.; Mahzarnia, A.; Stout, J. A.; Moon, H. S.; Han, Z. Y.; Vogelstein, J. T.; Badea, A.
10.1101/2025.02.05.636582 — neuroscience — Posted on 2025-02-06
4154 A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism
Long, J.; Jones, S. G.; Serna, A.; van Reijmersdal, B.; Kampshoff, F.; Aibar, S.; Verstreken, P.; Huynen, M. A.; Luethy, K.; Coll-Tane, M.; Schenck, A.
10.1101/2025.02.03.636180 — neuroscience — Posted on 2025-02-06
4155 Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila
Arntsen, C.; Grenon, J.; Chauvel, I.; Fraichard, S.; Dupas, S.; Cortot, J.; Audette, K.; Musso, P.-Y.; Stanley, M.
10.1101/2025.02.06.636883 — neuroscience — Posted on 2025-02-06
4156 Guiding G protein signaling by target enhancement of GPCRs
Muecher, B.; Charles, A. G.; Cyganek, L.; Bruegmann, T.; Dalkara, D.; Siveke, I.; Herlitze, S.
10.1101/2025.02.06.636923 — neuroscience — Posted on 2025-02-06
4157 PET imaging of an antisense oligonucleotide in the living non-human primate brain using click chemistry
Cook, B. E.; Pickel, T. C.; Nag, S.; Bolduc, P. N.; Beshr, R.; Forsberg Moren, A.; Muste, C.; Boscutti, G.; Jiang, D.; Yuan, L.; Datta, P.; Ochniewicz, P.; Khani Meynaq, Y.; Tang, S.-P.; Plisson, C.; Amatruda, M.; Zhang, Q.; DuBois, J. M.; Delavari, A.; Klein, S. K.; Polyak, I.; Shoroye, A.; Girmay, S.; Halldin, C.; Martarello, L.; Peterson, E. A.; Kaliszczak, M.
10.1101/2025.02.06.636694 — neuroscience — Posted on 2025-02-06
4161 A single low-dimensional neural component of motor unit activity explains force generation across repetitive isometric tasks
Cabral, H. V.; Inglis, J. G.; Pourreza, E.; Dos Santos, M. A.; Cosentino, C.; O'Reilly, D.; Delis, I.; Negro, F.
10.1101/2025.02.04.635938 — neuroscience — Posted on 2025-02-06
4162 Single-nucleus analysis reveals dysregulated oxidative phosphorylation in Down syndrome basal forebrain at birth
West, N. R.; Arachchilage, K. H.; Knaack, S.; Hosseini, M.; Risgaard, R. D.; MacGregor, S.; Kumarage, P.; Martinez, J. L.; Wang, D.; Sousa, A. M. M.; Bhattacharyya, A.
10.1101/2025.02.05.636750 — neuroscience — Posted on 2025-02-06
4164 Neuronal Silencing and Protection in a Mouse Model of Demyelination
Das, A.; Borovicka, J.; Tobin, H.; Bhatia, S.; Icardi, J.; Tahmasebi, G.; Agochiya, P.; Singh, S.; Trapp, B.; Dana, H.
10.1101/2025.02.03.636344 — neuroscience — Posted on 2025-02-06
4166 Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics
Lakunina, A.; Socha, K. Z.; Ladd, A.; Bowen, A. J.; Chen, S.; Colonell, J.; Doshi, A.; Karsh, B.; Krumin, M.; Kulik, P.; Li, A.; Neutens, P.; O'Callaghan, J.; Olsen, M.; Putzeys, J.; Tilmans, H. A. C.; Ye, Z.; Welkenhuysen, M.; Hausser, M.; Koch, C.; Ting, J.; Neuropixels Opto Consortium, ; Dutta, B.; Harris, T. D.; Steinmetz, N. A.; Svoboda, K.; Siegle, J. H.; Carandini, M.
10.1101/2025.02.04.636286 — neuroscience — Posted on 2025-02-06
4170 A Generalist Intracortical Motor Decoder
Ye, J.; Rizzoglio, F.; Smoulder, A.; Mao, H.; Ma, X.; Marino, P.; Chowdhury, R. H.; Moore, D. D.; Blumenthal, G.; Hockeimer, W.; Kunigk, N. G.; Mayo, J. P.; Batista, A. P.; Chase, S. M.; Rouse, A. G.; Boninger, M. L.; Greenspon, C.; Schwartz, A. B.; Hatsopoulos, N.; Miller, L. E.; Bouchard, K.; Collinger, J.; Wehbe, L.; Gaunt, R.
10.1101/2025.02.02.634313 — neuroscience — Posted on 2025-02-06
4172 Meaning for reading: The neurocognitive basis of semantic reading impairment after stroke
Staples, R.; Dickens, J. V.; Dyslin, S. M.; DeMarco, A. T.; Snider, S. F.; Friedman, R. B.; Turkeltaub, P. E.
10.1101/2025.02.06.636920 — neuroscience — Posted on 2025-02-06
4173 USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms
Williamson, M. G.; Heon-Roberts, R.; Franks, S. N. J.; Mock, E.; Jones, H. B. L.; Malpartida, A. B.; Britti, E.; Bassal, M.; Lavelle, M.; Connor, J.; Mogas Barcons, A.; Hammond, K.; Savory, K.; Rai, P.; Lavayssiere, A.; McGuinness, W.; Sepke, N.; Vowles, J.; Vendrell, I.; Guenther, F.; Kessler, B. M.; Cowley, S. A.; England, K. S.; Murphy, E. J.; Davis, J. B. L.; Wade-Martins, R.; Ryan, B. J.
10.1101/2025.02.03.636341 — neuroscience — Posted on 2025-02-06
4174 Effects of Global Ripk2 Genetic Deficiency in Aged Mice following Experimental Ischemic Stroke
Howell, J. A.; Larochelle, J.; Gunraj, R. E.; Stansbury, S. M.; Liu, L.; Yang, C.; Candelario-Jalil, E.
10.1101/2025.02.05.636687 — neuroscience — Posted on 2025-02-06
4176 Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices
Joyce, M. K. P.; Datta, D. P.; Arellano, J. I.; Duque, A.; Morozov, Y. M.; Morrison, J. H.; Arnsten, A. F.
10.1101/2025.02.05.636752 — neuroscience — Posted on 2025-02-06
4178 Consistent cerebellar pathway-cognition associations across pre-adolescents & young adults: a diffusion MRI study of 9000+ participants
Zekelman, L. R.; Cetin Karayumak, S.; Chen, Y.; Almeida, M.; Haitz Legarreta, J.; Rushmore, R. J.; Pieper, S.; Lan, Z.; Desmond, J. E.; Baird, L. C.; Makris, N.; Rathi, Y.; Zhang, F.; Golby, A. J.; O'Donnell, L. J.
10.1101/2025.02.05.636737 — neuroscience — Posted on 2025-02-06
4181 Age-related differences in the association between REM sleep and the polygenic risk for Parkinson's disease
Talwar, P.; Mortazavi, N.; Koshmanova, E.; Muto, V.; Degueldre, C.; Berthomier, C.; Collette, F.; Bastin, C.; Phillips, C.; Maquet, P.; Mikhail, Z.; Vandewalle, G.
10.1101/2025.02.05.636657 — neuroscience — Posted on 2025-02-06
4185 Learning single-cell spatial context through integrated spatial multiomics with CORAL
He, S.; Bieniosek, M.; Song, D.; Zhou, J.; Chidester, B.; Wu, Z.; Boen, J.; Sharma, P.; Trevino, A. E.; Zou, J.
10.1101/2025.02.01.636038 — bioinformatics — Posted on 2025-02-06
4186 3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions
Harun, A.; Bendele, N.; Khalil, M. I.; Vasquez, I.; Djuanda, J.; Posey, R.; Christopher, G.; Bickel, U.; Gruev, V.; Tropp, J.; Egan, P.; Srivastava, I.
10.1101/2025.02.01.636085 — bioengineering — Posted on 2025-02-06
4188 Functional Impact of Glycosylation and Splicing Variants of LRIG1 on EGFR Proteostasis in Cancer
Kondo, J.; Nagao, H.; Oyama, K.; Sakon, D.; Nakayama, H.; Takamatsu, S.; Miyoshi, E.
10.1101/2025.02.05.636756 — biochemistry — Posted on 2025-02-06
4192 Generation of C9orf72h370 mice, an intron 1 humanised C9orf72 repeat-expansion knock-in model
Nair, R. R.; Carcole, M.; Thompson, D.; Tibbit, C.; McLeod, R.; Cammack, A.; Jakubcova, T.; Biggs, D.; Wyles, M.; Parker, M.; Caulder, A.; Teboul, L.; Fisher-Ward, C. L.; Awan, A. R.; Flower, M.; Davies, B.; Isaacs, A. M.; Fisher, E. M.; Cunningham, T. J.
10.1101/2025.02.06.636691 — molecular biology — Posted on 2025-02-06
4195 HP-Bodies - Ancestral Condensates that Regulate RNA Turnover and Protein Translation in Bacteria
Guan, J.; Huto, R. L.; Rai, A.; Azaldegui, C. A.; Ortiz-Rodriguez, L. A.; Biteen, J. S.; Freddolino, L.; Jakob, U.
10.1101/2025.02.06.636932 — microbiology — Posted on 2025-02-06
4196 Chromosome segregation in Escherichia coli involves DNA binding by the MinC-MinD complex
Palanisamy, N.; Klauss, L.; Lefebvre, M.; Liang, J.; Hofhaus, G.; Zeelen, J. P.; Urban, M.; Öztürk, M. A.; Merker, S.; Luzarowski, M.; Ruppert, T.; Di Ventura, B.
10.1101/2025.02.06.636808 — microbiology — Posted on 2025-02-06
4198 Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to potentiate the activity bedaquiline and other antitubercular drugs
Fountain, A. J.; Waller, N. J.; Cheung, C.-Y.; Jowsey, W.; Chrisp, M. T.; Troll, M.; Edelstein, P. H.; Cook, G. M.; McNeil, M. B.; Ramakrishnan, L.
10.1101/2025.02.06.636695 — microbiology — Posted on 2025-02-06
4199 Dietary quorum quenching AHL lactonase impairs the adaptation of commensal bacterium to host innate immunity
Xia, R.; Yao, Y.; Meng, D.; Zhao, Y.; Xu, S.; Jin, Y.; Zhang, Z.; Yang, Y.; Ran, C.; Zhou, Z.
10.1101/2025.02.05.636741 — microbiology — Posted on 2025-02-06
4200 Whole-body Bacteriophage Distribution Characterized by a Physiologically based Pharmacokinetic Model
Echterhof, A.; Dharmaraj, T.; Blankenberg, P.; Targ, R.; Bollyky, P.; Smith, N.; Blankenberg, F.
10.1101/2025.02.06.636931 — microbiology — Posted on 2025-02-06
4203 Multivariate Neural Markers of Individual Differences in Thought Control Difficulties
DeRosa, J. T.; Smolker, H. R.; Kim, H.; Groff, B.; Lewis-Peacock, J.; Banich, M. T.
10.1101/2025.02.04.636283 — neuroscience — Posted on 2025-02-06
4204 Centella asiatica improves sleep quality and quantity in aged mice
Dovek, L.; Tinsley, C. E.; Gutowsky, K.; McDaniel, K.; Potter, Z.; Ruffins, M.; Milman, N.; Wong, C.; Soumyanath, A.; Gray, N. E.; Lim, M.
10.1101/2025.02.01.636070 — neuroscience — Posted on 2025-02-06
4205 Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition
Saenz de Miera, C.; Bellefontaine, N.; Silveira, M. A.; Fortin, C. N.; Zampieri, T. T.; Donato, J.; Williams, K. W.; Mendes de Silva, C.; Heikkinen, L.; Broberger, C.; Frazao, R.; Elias, C. F.
10.1101/2025.02.03.636271 — neuroscience — Posted on 2025-02-06
4206 Interferometric Ultra-High Resolution 3D Imaging through Brain Sections
Gao, H.-C.; Xu, F.; Cheng, X.; Bi, C.; Zheng, Y.; Li, Y.; Chen, T.; Li, Y.; Chubykin, A. A.; Huang, F.
10.1101/2025.02.03.636258 — neuroscience — Posted on 2025-02-06
4207 Single-cell Transcriptomics Unravel Stereocilia Degeneration as a Key Contributor to Age-related Vestibular Dysfunction in Mice and Humans
Kulasooriya, S.; Liu, H.; Vijayakumar, S.; Bloom, C.; Tu, S.; Borgmeier, B.; Zhou, M.; Tao, L.; Kachar, B.; He, D. Z.
10.1101/2025.02.02.636113 — neuroscience — Posted on 2025-02-06
4208 Decoding continuous goal-directed movement from human brain-wide intracranial recordings.
Ottenhoff, M. C.; Verwoert, M.; Goulis, S.; Tousseyn, S.; van Dijk, J. P.; Shanechi, M. M.; Sani, O. G.; Kubben, P.; Herff, C.
10.1101/2025.02.05.636287 — neuroscience — Posted on 2025-02-06
4210 Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs
Labarre, B. A.; King, D.; Ploumakis, A.; Morales Pinzon, A.; Guttmann, C. R. G.; Patsopoulos, N.; Chitnis, T.
10.1101/2025.02.05.636293 — neuroscience — Posted on 2025-02-06
4211 Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice
Poulson, S. J.; Skvortsova, A.; Paz, L. V.; Cui, W.; Mandatori, A.; Burek, J.; Zahra, F. T.; Dinh, A.; Boorman, D. C.; Liang, L.; Mogil, J. S.; Martin, L. J.
10.1101/2025.02.04.636522 — neuroscience — Posted on 2025-02-06
4212 Multivalency controls the growth and dynamics of a biomolecular condensate
Saurabh, S.; von Hofe, J.; Abacousnac, J.; Chen, M.; Sasazawa, M.; Kristiansen, I. J.; Westrey, S.; Grier, D.
10.1101/2025.02.01.636084 — biophysics — Posted on 2025-02-06
4216 Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals
Shaikhqasem, A.; Hamdi, F.; Machner, L.; Parthier, C.; Breithaupt, C.; Kyrilis, F. L.; Feller, S. M.; Kastritis, P. L.; Stubbs, M. T.
10.1101/2025.02.06.636927 — biochemistry — Posted on 2025-02-06
4219 Discovering Symbolic Cognitive Models from Human and Animal Behavior
Castro, P. S.; Tomasev, N.; Anand, A.; Sharma, N.; Mohanta, R.; Dev, A.; Perlin, K.; Jain, S.; Levin, K.; Elteto, N.; Dabney, W.; Novikov, A.; Turner, G. C.; Eckstein, M. K.; Daw, N. D.; Miller, K. J.; Stachenfeld, K. L.
10.1101/2025.02.05.636732 — animal behavior and cognition — Posted on 2025-02-06
4223 Genome-wide identification and characterization of QTLs for transcriptional noise in human midbrain cells
HIROSE, N.; MIZUNO, S.; NIWA, Y.; HARA, T.; YAMAMOTO, H.; KOYAMA, E.; UEDA, J.; TSUBOI, T.; TAKATA, A.
10.1101/2025.02.01.635574 — genetics — Posted on 2025-02-06
4228 The diversity of cellular systems involved in carbonate precipitation by Escherichia coli
Jennings, M. E.; Breley, G. J.; Blackwell, R. S.; Drabik, A.; Gisser, K. R.; Kainrad, J. R.; Ligman, V.; Proctor, J.; Deshler, R.; O'Hart, B. A.; Rivera, A.; Centrella, L.; Bonn, S.; Chaudhry, B.; Barton, H. A.
10.1101/2025.02.06.636833 — microbiology — Posted on 2025-02-06
4229 Export dynamics of protists across the southern subtropical frontal zone reveal taxon-specific patterns
Ong, D. R. Y.; Gutierrez-Rodriguez, A.; Bilewitch, J.; Nodder, S.; Stukel, M. R.; Decima, M.; Lopes dos Santos, A.
10.1101/2025.02.06.636886 — microbiology — Posted on 2025-02-06
4235 Transcriptional control of T cell tissue adaptation and effector function in infants and adults
Szabo, P. A.; Levitin, H. M.; Connors, T. J.; Chen, D.; Jin, J.; Thapa, P.; Guyer, R.; Caron, D. P.; Gray, J. I.; Matsumoto, R.; Kubota, M.; Brusko, M.; Brusko, T. M.; Farber, D. L.; Sims, P. A.
10.1101/2025.02.01.636039 — immunology — Posted on 2025-02-06
4238 Editing strigolactone biosynthesis genes in tomato reveals novel phenotypic effects and highlights D27 as a key target for parasitic weed resistance
Nicolia, A.; Cuccurullo, A.; Tamada, K.; Yoneyama, K.; Rambla, J. L.; Granell, A.; Camerlengo, F.; Festa, G.; Francese, G.; Contaldi, F.; D'Alessandro, A.; Rigano, M. M.; Principio, L.; D'Agostino, N.; Cardi, T.
10.1101/2025.02.01.636032 — genetics — Posted on 2025-02-06
4239 A simple method to classify behaviours of aerial predators using tri-axial high-frequency accelerometers
Garcia-Silveira, D.; Benhamou, S.; Lopez Ricaurte, L.; Hernandez-Pliego, J.; Duriez, O.; Bustamante, J.
10.1101/2025.02.01.636019 — ecology — Posted on 2025-02-06
4241 Pupillometry Reveals Autonomic Adjustments During Diving Reflex in Face Immersion Apnea
Rizzuto, V.; Montanari, R.; Mesin, L.; Bortolozzo-Gleich, H.; Laurino, M.; Bonneh, Y.; Yellin, D.; Laganovska, G.; Vanags, J.; Gemignani, A.
10.1101/2025.01.31.635967 — physiology — Posted on 2025-02-06
4247 Positive associations between growth and thermal tolerance in the reef-building coral Montipora capitata
Walker, N. S.; Luke, H.; Miller, S.; Kealoha, D.; Caruso, C.; Johnston, E. C.; Mujica, E. M.; Hancock, J. R.; Drury, C.
10.1101/2025.01.31.635983 — ecology — Posted on 2025-02-06
4248 Thermodynamics shape the in vivo enzyme burden of glycolytic pathways
Khana, D. B.; Jen, A.; Shishkova, E.; Thusoo, E.; Williams, J.; Henkel, A.; Stevenson, D. M.; Coon, J. J.; Amador-Noguez, D.
10.1101/2025.01.31.635972 — systems biology — Posted on 2025-02-06
4253 The Sequential Multispecies Coalescent
Milkey, A.; Chen, M.-H.; Wang, Y.-B.; Li, A.; Lewis, P.
10.1101/2025.01.31.635964 — evolutionary biology — Posted on 2025-02-06
4254 Epigenomic insights into extreme longevity in the world's oldest terrestrial animal, Jonathan
Vaisvil, B.; Schmitt, D. W.; Jones, A.; Kapatral, V.; Ford, J. M.; Taylor, M. L.; Colwell, M.; Hollins, J.; Pascucci, S.; Weissenow, K.; Rost, B.; Notin, P.; Gerlach, J.; Terwilliger, T. C.; Hung, L.-W.; Jensen, L. J.; Horvath, S.; Faulk, C.; Ma, Y.; Clark, S. W.
10.1101/2025.02.05.636284 — genomics — Posted on 2025-02-06
4255 Draft Genome of the Endangered Visayan Spotted Deer (Rusa alfredi)
Javier, M. C. F.; Noblezada, A. C.; Sienes, P. M. Q.; Guino-o, R. S.; Palomar-Abesamis, N.; Malay, M. C. D.; del Castillo, C. S.; Ferriols, V. M. E. N.
10.1101/2025.02.05.636739 — genomics — Posted on 2025-02-06
4258 Proteomics-based models of gene expression and cellular control of cotton fiber development
Lee, Y.; Yang, P.; Rani, H.; Miller, G.; Grover, C. E.; Swaminathan, S.; Zabotina, O. A.; Wendel, J. F.; Xie, J.; Szymanski, D. B.
10.1101/2025.02.05.636703 — plant biology — Posted on 2025-02-06
4259 From discovery to translation: Endogenous substrates of OAT1 and OAT3 as clinical biomarkers for renal secretory function
Thakur, A.; Singh, D. K.; Hart, K. D.; Kis, E.; Gaborik, Z.; Denton, T. T.; Clarke, J. D.; Paine, M. F.; Prasad, B.
10.1101/2025.02.05.636675 — pharmacology and toxicology — Posted on 2025-02-06
4260 Profiling serum oxylipin metabolites across melanoma subtypes and immunotherapy responders
Goodman, A. C.; Michel, K. M.; MacBeth, M. L.; Turner, J. A.; Tobin, R. P.; Robinson, W. A.; Couts, K. L.
10.1101/2025.02.05.636637 — cancer biology — Posted on 2025-02-06
4262 Cardiac fibrosis inhibitor CTPR390 prevents structural and morphological changes in collagen and fibroblasts of engineered human connective tissue
Maestro, D.; Palanca, A.; Llarena, I.; DeGrave, A. N.; Guedes, G.; de Oliveira, G. H.; Coelho Conceicao, A. L.; Mieites, V.; Icardo De La Escalera, J. M.; Sanchez-Cano, C.; Conde, O. M.; Lutz, S.; Cortajarena, A. L.; Villar, A. V.
10.1101/2025.01.15.633162 — biochemistry — Posted on 2025-02-06
4263 Leopard Cats Occupied Human Settlements in China for 3,500 years before the Arrival of Domestic cats in 600-900 CE around the Tang Dynasty
Han, Y.; Hu, S.; Liu, K.; Xu, X.; Doherty, S.; Jamieson, A. E.; Manin, A.; Martins, S. G.; Yang, M.; Yu, C.; Wang, J.; Wu, Z.; Chen, C.; Han, S.; Lu, D.; Peng, L.; Wu, X.; Li, Z.; Fan, W.; Cai, Q.; Cui, Z.; Yuan, J.; Li, Z.; Liu, Y.; Li, Z.; Liu, Z.; Ma, Q.; Shao, J.; Sun, Z.; Xing, F.; Yang, W.; Yang, S.; Yue, L.; Zhang, P.; Wang, W.; Zhang, H.; Zhuang, Y.; Sun, X.; Pan, Y.; Wu, X.; Frantz, L. A. F.; Yu, H.; Alves, J. M.; Larson, G.; Luo, S.-j.
10.1101/2025.01.31.635809 — evolutionary biology — Posted on 2025-02-06
4265 Fine-tuning mechanical constraints uncouples patterning and gene expression in murine pseudo-embryos
Pineau, J.; Ng, J. W.; Mayran, A.; Lopez-Delisle, L.; Osteil, P.; Shoushtarizadeh, A.; Duboule, D.; Gobaa, S.; Gregor, T.
10.1101/2025.01.28.635012 — developmental biology — Posted on 2025-02-06
4267 Accelerated signal propagation speed in human neocortical dendrites
Olah, G.; Lakovics, R.; Shapira, S.; Leibner, Y.; Szucs, A.; Csajbok, E. A.; Barzo, P.; Molnar, G.; Segev, I.; Tamas, G.
10.1101/2022.09.30.510270 — neuroscience — Posted on 2025-02-06
4268 Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.
Moon, H.; Mori, H.; Chen, Q.; Patino, A.; Ramamurthy, K.; Penzvalto, Z.; Choi, J.; McPherson, J. D.; Snyder, J.; Cardiff, R. D.; Borowsky, A. D.
10.1101/2025.02.02.636128 — cancer biology — Posted on 2025-02-06
4269 Tumor-associated stroma shapes the spatial tumor immune microenvironment of primary Ewing sarcomas
Kuo, C.; Giannikou, K.; Wang, N.; Warren, M.; Goodspeed, A.; Shillingford, N.; Hayashi, M.; Raredon, M. S. B.; Amatruda, J.
10.1101/2025.01.31.635996 — cancer biology — Posted on 2025-02-06
4270 Enhanced Detection of Glioblastoma Vasculature with Superparamagnetic Iron Oxide Nanoparticles and MRI
Janowicz, P. W.; Boele, T.; Maschmeyer, R. T.; Gholami, Y. H.; Kempe, E. G.; Stringer, B. W.; Stoner, S. P.; Zhang, M.; Thompson, T. d.-T.; Williams, F.; Touffu, A.; Munoz, L.; Kuncic, Z.; Brighi, C.; Waddington, D. E. J.
10.1101/2025.02.02.635583 — cancer biology — Posted on 2025-02-06
4271 Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D
Chowdhury, B.; Zhu, K.; Li, C.; Luebeck, J.; Chapman, O. S.; Kraft, K.; Zhang, S.; Chavez, L.; Henssen, A. G.; Mischel, P. S.; Chang, H.; Bafna, V.
10.1101/2025.02.01.636064 — cancer biology — Posted on 2025-02-06
4272 LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism
Fidaleo, A. M.; Bach, M. D.; Orbeta, S.; Abdullaev, I. F.; Martino, N.; Adam, A. P.; Boulos, M. A.; Dulin, N. O.; Paul, A. R.; Kuo, Y.-H.; Mongin, A. A.
10.1101/2025.02.02.636139 — cancer biology — Posted on 2025-02-06
4274 Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion
Saraswathibhatla, A.; Rabbi, M. F.; Varma, S.; Srivastava, V.; Ilina, O.; Alyafei, N. H. K.; Hodgson, L.; Gartner, Z.; Friedl, P.; West, R.; Kim, T. B.; Chaudhuri, O.
10.1101/2025.01.31.635980 — biophysics — Posted on 2025-02-06
4278 EPHA2 and scavenger receptor-directed trafficking enhances endosomal leakiness and antisense therapy delivery
Marco Martin, S.; Walsh, P. J.; Revenko, A. S.; Thomason, P. A.; McGarry, L.; MacLeod, A. R.; Ansel, S.; Tataran, D.; Bushell, M.; Braconi, C.; Norman, J. C.
10.1101/2025.02.05.635637 — cell biology — Posted on 2025-02-06
4279 A Temporal and Spatial Atlas of Adaptive Immune Responses in the Lymph Node Following Viral Infection
Jiang, S.; Mantri, M.; Maymi, V.; Leddon, S. A.; Schweitzer, P.; Bhandari, S.; Holdener, C.; Ntekas, I.; Vollmers, C.; Flyak, A. I.; Fowell, D. J.; Rudd, B. D.; De Vlaminck, I.
10.1101/2025.01.31.635509 — immunology — Posted on 2025-02-06
4280 Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral Therapy
Cattin, A.; Pham, T. N.; Dias, J.; Do Rosario, N. F.; Marchand, L. R.; Volodina, O.; Guimond, J.-V.; Patey, N.; Li, Y.; Beland, K.; Jenabian, M.-A.; Estaquier, J.; Haddad, E.; Cohen, E. A.; Ancuta, P.
10.1101/2025.01.31.635552 — immunology — Posted on 2025-02-06
4282 Cutaneous lupus features specialized stromal niches and altered retroelement expression
Gehlhausen, J. R.; Kong, Y.; Baker, E.; Ramachandran, S.; Koumpouras, F.; Ko, C.; Vesely, M.; Little, A.; Damsky, W.; King, B.; Iwasaki, A.
10.1101/2025.02.01.636053 — immunology — Posted on 2025-02-06
4283 Fatty Acid Transport Protein-2 (FATP2) Inhibition Enhances Glucose Tolerance through α-Cell-mediated GLP-1 Secretion
Khan, S.; Gaivin, R. J.; Liu, Z.; Li, V.; Samuels, I.; Son, J.; Osei-Owusu, P.; Garvin, J. L.; Accili, D.; Schelling, J. R.
10.1101/2025.01.31.635976 — physiology — Posted on 2025-02-06
4284 Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages
Ma, R.; Gong, L.; Dong, C.; Utsumi, T.; Qi, J.; Zhuang, Z.; Zhang, X.; Yang, Y.; McConnell, M. J.; Huang, H.-C.; Iwakiri, Y.
10.1101/2025.01.31.634947 — pathology — Posted on 2025-02-06
4286 Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells
Kawasaki, T.; Nishimura, T.; Tani, N.; Ramos, C.; Karaulanov, E.; Shinya, M.; Saito, K.; Taylor, E.; Ketting, R. F.; Ishiguro, K.-i.; Tanaka, M.; Siegfried, K.; Sakai, N.
10.1101/2024.11.17.623901 — developmental biology — Posted on 2025-02-05
4290 BabyPy: a brain-age model for infancy, childhood and adolescence
Biondo, F.; O'Muircheartaigh, J.; Bethlehem, R. A. I.; Seidlitz, J.; Alexander-Bloch, A.; Elison, J.; D'Sa, V.; Deoni, S. C. L.; Bruchhage, M. M. K.; Cole, J. H.
10.1101/2025.02.05.636598 — neuroscience — Posted on 2025-02-05
4292 A neural basis for flexible perceptual inference
Schwarcz, J.; Bauer, J.; Rajabi, H.; Marmur, G.; Lottem, E.; Kadmon, J.
10.1101/2025.02.05.636696 — neuroscience — Posted on 2025-02-05
4293 Axonal injury signaling is restrained by a spared synaptic branch
Smithson, L. J.; Zang, J. L.; Junginger, L.; Waller, T. J.; Reilly-Jankowiak, L.; Khan, S.; Li, Y.; Cai, D.; Collins, C. A.
10.1101/2024.11.07.622420 — neuroscience — Posted on 2025-02-05
4294 Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation
Nappi, M.; Frampton, D. J. A.; Kusay, A. S.; Wang, K.; Miceli, F.; Liin, S. I.; Taglialatela, M.; Pantazis, A.
10.1101/2025.02.04.636443 — biophysics — Posted on 2025-02-05
4295 Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics
Grosjean, P.; Shevade, K.; Nguyen, C.; Ancheta, S.; Mader, K.; Franco, I.; Heo, S.-J.; Lewis, G.; Boggess, S.; De Domenico, A.; Ullian, E.; Shafer, S.; Litterman, A.; Przybyla, L.; Keiser, M. J.; Ifkovits, J.; Yala, A.; Kampmann, M.
10.1101/2025.02.04.636489 — bioinformatics — Posted on 2025-02-05
4298 De novo design of Ras isoform selective binders
Zhang, J. Z.; Li, X.; Liu, C.; Jiang, H.; Wu, K.; Baker, D.
10.1101/2024.08.29.610300 — bioengineering — Posted on 2025-02-05
4300 Training Generalized Segmentation Networks with Real and Synthetic Cryo-ET data.
Purnell, C.; Heebner, J.; Nguyen, L. T.; Swulius, M. T.; Hylton, R.; Kabonick, S.; Grillo, S.; Grillo, M.; Grigoryev, S.; Heberle, F. A.; Waxham, N.; Swulius, M. T.
10.1101/2025.01.31.635598 — cell biology — Posted on 2025-02-05
4301 Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation in the brain and periphery
Huang, S.; Patkar, O. L.; Schulze, S.; Carter-Cusack, D.; Millard, S.; Ranpura, G.; Green, E. K.; Maxwell, E.; Kanesarajah, J.; Cowin, G.; Stimson, D.; Kurniawan, N. D.; Keshvari, S.; Allavena, R.; Pettit, A.; Irvine, K. M.; Hume, D. A.
10.1101/2025.01.30.635395 — immunology — Posted on 2025-02-05
4304 Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contact Sites Precede Major (Mal)adaptations in Aging Skeletal Muscle and are Prevented by Exercise
Allen, R. J.; Kronemberger, A.; Shi, Q.; Pope, M.; Cuadra-Munoz, E.; Son, W.; Song, L.-S.; Anderson, E. J.; Pereira, R. O.; Lira, V. A.
10.1101/2025.01.14.633043 — physiology — Posted on 2025-02-05
4305 Deep visual multi-omics profiling reveals mechanisms that underly cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma
Bolck, H. A.; Migh, E.; Kriston, A.; Zajac, N.; Kreutzer, S.; Totu, T.; Leary, P.; Kovacs, F.; Rutishauser, D.; Pfammatter, S.; Grossmann, J.; Litchfield, C.; Buljan, M.; Rupp, N. J.; Horvath, P.; Moch, H.
10.1101/2025.01.31.635927 — cancer biology — Posted on 2025-02-05
4311 Systemic Factors Affect Bone Health in SMA Type II Patients and a Mouse Model of SMA
Grandi, F.; Pezet, S.; Arnould, A.; Mazzucchi, S.; Gidaja, E.; Astord, S.; Chapart, M.; Vasseur, S.; Ricupero, A.; Ernu, M.; Sampaio, Y.; Cohen-Tannoudji, M.; Meunier, P.; Benkhelifa-Ziyyat, S.; Miladi, L.; Vialle, R.; Smeriglio, P.
10.1101/2025.02.05.636673 — genomics — Posted on 2025-02-05
4312 Analyses of transposable elements in arbuscular mycorrhizal fungi support evolutionary parallels with filamentous plant pathogens
Oliveira, J. I.; Lane, C.; Mugambi, K.; Yildirir, G.; Nicol, A. M.; Kokkoris, V.; Banchini, C.; Dadej, K.; Dettman, J.; Stefani, F.; Corradi, N.
10.1101/2024.11.04.621924 — genomics — Posted on 2025-02-05
4314 Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Han, W.; Yuan, B.; Fan, X.; Li, W.; Yuan, Y.; Zhang, Y.; Wang, S.; Shan, S.; Hafner, M.; Wang, Z.; Qiu, Z.
10.1101/2025.02.04.636546 — molecular biology — Posted on 2025-02-05
4315 Specificity and Mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system
Belukhina, S.; Saudemont, B.; Depardieu, F.; Lorthios, T.; Maviza, T. P.; Livenskyi, A.; Serebryakova, M.; Aleksandrova, M.; Ukholkina, E.; Burmistrova, N.; Sergiev, P. V.; Libiad, M.; Dubrac, S.; Barras, F.; Motorin, Y.; Marchand, V.; Hagelueken, G.; Isaev, A.; Bikard, D.; Rouillon, C.
10.1101/2025.02.04.636281 — microbiology — Posted on 2025-02-05
4316 Survival of the unfittest: clinical emergence of hyper-multidrug-resistant Nakaseomyces glabratus with rare nonfunctional Erg3 and Erg11 and severely impaired fitness.
Carolus, H.; Biriukov, V.; Vreys, J.; Lobo Romero, C.; Paolo Herrera, J.; Vergauwen, R.; Sofras, D.; Vanreppelen, G.; Vinken, L.; Britto Xavier, B.; Gabaldon, T.; Lagrou, K.; Naesens, R.; Van Dijck, P.
10.1101/2025.02.05.636719 — microbiology — Posted on 2025-02-05
4317 CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis
Sharif, A.; Jeffers, M. S.; Fergusson, D. A.; Bapuji, R.; Nicholls, S. G.; Humphrey, J.; Johnston, W.; Mitchell, E.; Speirs, M.-A.; Stronghill, L.; Vuckovic, M.; Wulf, S.; Shorr, R.; Dowlatshahi, D.; Corbett, D.; Lalu, M. M.
10.1101/2024.09.25.614925 — neuroscience — Posted on 2025-02-05
4320 3D-bioprinted marine bacteria for the degradation of bioplastics
He, L.; Cai, H.; Gona, R. S.; Gangan, M. S.; Lai, T.; Silberstein, M. N.; Meyer, A. S.
10.1101/2025.02.05.636490 — synthetic biology — Posted on 2025-02-05
4321 ATP-release pannexin channels are gated by lysophospholipids
Henze, E.; Burkhardt, R. N.; Fox, B. W.; Schwertfeger, T. J.; Gelsleichter, E.; Michalski, K.; Kramer, L.; Lenfest, M.; Boesch, J. M.; Lin, H.; Schroeder, F. C.; Kawate, T.
10.1101/2023.10.23.563601 — biophysics — Posted on 2025-02-05
4322 ASTRO: Automated Spatial Whole-Transcriptome RNA-Expression Workflow
Zhang, D.; Chu, Z.; Huo, Y.; Bai, Z.; Fan, R.; Lu, J.; Gerstein, M.
10.1101/2025.01.24.634814 — bioinformatics — Posted on 2025-02-05
4324 Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5
Sebesta, M.; Skubnik, K.; Morton, W. S.; Kravec, M.; Linhartova, K.; Klapstova, V.; Novacek, J.; Kubicek, K.; Bryja, V.; Vacha, R.; Stefl, R.
10.1101/2025.02.05.636647 — biochemistry — Posted on 2025-02-05
4325 Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies.
Oakley, S.; Marshall, K. E.; Meisl, G. E.; Maina, M. B.; Milton, R.; Vorley, T.; Storey, J.; Harrington, C.; WISCHIK, C. M.; Xue, W.-F.; Copsey, A.; Serpell, L.
10.1101/2025.02.05.636249 — biochemistry — Posted on 2025-02-05
4326 Heterologous production, purification and crystallization of 24C-sterol methyltransferase from Candida albicans
Mpontshane, N. S.; Fairhead, M.; Opperman, D. J.; Hart, R.; Van Breda, V.; Von Delft, F.; Koekemoer, L.; Tolmie, C.
10.1101/2025.02.05.636639 — biochemistry — Posted on 2025-02-05
4327 SiR-XActin: A fluorescent probe for imaging actin dynamics in live cells
Nasufovic, V.; Kompa, J.; Lindamood, H. L.; Bluemke, M.; Koch, B.; Levario-Diaz, V.; Weber, K.; Maager, M.; Cavalcanti-Adam, E. A.; Vitriol, E. A.; Arndt, H.-D.; Johnsson, K.
10.1101/2025.02.04.636537 — biochemistry — Posted on 2025-02-05
4328 Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
Bismut, S.; Schneider, M. M.; Miyasaki, M.; Feng, Y.; Wilde, E. J.; Gunawardena, M. D.; Knowles, T. P. J.; Kaminski Schierle, G. S.; Itzhaki, L. S.; Kumita, J. R.
10.1101/2025.02.04.636406 — biochemistry — Posted on 2025-02-05
4329 Transcription can be sufficient, but is not necessary, to advance replication timing
Vouzas, A.; Sasaki, T.; Rivera-Mulia, J. C.; Turner, J. L.; Brown, A. N.; Alexander, K. E.; Brueckner, L.; van Steensel, B.; Gilbert, D. M.
10.1101/2025.02.04.636516 — genomics — Posted on 2025-02-05
4333 Cathartocytosis: Jettisoning of Unwanted Material during Cellular Reprogramming
Brown, J. W.; Lin, X.; Nicolazzi, G. A.; Liu, X.; Nguyen, T.; Radyk, M. D.; Burclaff, J.; Mills, J. C.
10.1101/2024.06.11.598489 — cell biology — Posted on 2025-02-05
4335 Diffusion-based size determination of solute particles: a method adapted for PSD proteins
Szabo, A. L.; Nagy-Kanta, E.; Jager, E. A.; Pongor, C. I.; Laki, M.; Laki, A. J.; Gaspari, Z.
10.1101/2025.02.05.636588 — molecular biology — Posted on 2025-02-05
4336 Cryo-EM structures reveal the PP2A-B55α and Eya3 interaction that can be disrupted by a peptide inhibitor
Shi, S.; Li, X.; Alderman, C.; Huang, W.; Wick, L.; Foulon, N.; Rossi, J.; Hu, W.; Cui, S.; Zheng, H.; Taylor, D. J.; Ford, H. L.; Zhao, R.
10.1101/2025.02.04.636346 — molecular biology — Posted on 2025-02-05
4338 Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
Miles, S. L.; Santillo, D.; Torraca, V.; Lopez Jimenez, A. T.; Jenkins, C.; Baker, S.; Baker, K. S.; Sancho-Shimizu, V.; Holt, K. E.; Mostowy, S.
10.1101/2025.02.05.636615 — microbiology — Posted on 2025-02-05
4341 From cyst to tapeworm: Transcriptome of Taenia solium in vitro activation and growth
Castaneda-Carpio, D.; Gutierrez-Loli, R.; Maravi-Jaime, J.; Del Aguila, S. W.; Villar-Davila, V.; Moyano, L. M.; Tapia Limonchi, R.; Chenet, S.; Guerra-Giraldez, C.
10.1101/2025.02.04.636528 — microbiology — Posted on 2025-02-05
4343 Completing the BASEL phage collection to unlock hidden diversity for systematic exploration of phage-host interactions
Humolli, D.; Piel, D.; Maffei, E.; Heyer, Y.; Agustoni, E.; Shaidullina, A.; Willi, L.; Imwinkelried, P.; Estermann, F.; Cuenod, A.; Buser, D. P.; Alampi, C.; Chami, M.; Egli, A.; Hiller, S.; Dunne, M.; Harms, A.
10.1101/2024.09.12.612763 — microbiology — Posted on 2025-02-05
4344 Klebsiella pneumoniae disrupts vasodilation by targeting eNOS post translational modifications via the type VI secretion system and the capsule polysaccharide
Rheman, S.; sa-Pessoa Graca Santos, J.; Buckley, C.; Lancaster, R.; Ross, C.; Zhang, X.; McCarron, J.; Curtis, T.; Bengoechea, J.
10.1101/2025.02.05.636584 — microbiology — Posted on 2025-02-05
4346 C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice
Tanaka, T.; Sasaki, N.; Krisnanda, A.; Amin, H. Z.; Ito, K.; Horibe, S.; Matsuo, K.; Hirata, K.-i.; Nakayama, T.; Rikitake, Y.
10.1101/2024.08.16.608245 — immunology — Posted on 2025-02-05
4349 Enterovirus D68 2A protease causes nuclear pore complex dysfunction and motor neuron toxicity
Zinn, K. M.; McLaren, M. W.; Imai, M. T.; Jayaram, M. M.; Rothestein, J. D.; Elrick, M. J.
10.1101/2025.01.23.632178 — neuroscience — Posted on 2025-02-05
4352 Power-law adaptation in the presynaptic vesicle cycle
Mikulasch, F. A.; Georgiev, S. V.; Rudelt, L.; Rizzoli, S. O.; Priesemann, V.
10.1101/2024.07.19.604253 — neuroscience — Posted on 2025-02-05
4355 H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas
Garcia Fabiani, M. B.; Haase, S.; Banerjee, K.; Zhu, Z.; McClellan, B.; Mujeeb, A.; Li, Y.; Tronrud, C. E.; Varela, M. L.; West, M. E. J.; Yu, J.; Kadiyala, P.; Taher, A.; NUNEZ, F. J.; Alghamri, M. S.; Comba, A.; Mendez, F.; Nicola Candia, A. J.; Salazar, B.; Nunez, F. M.; Edwards, M.; Qin, T.; Cartaxo, R. T.; Niculcea, M.; Koschmann, C.; Venneti, S.; Puigdelloses Vallcorba, M.; Nasajpour, E.; Pericoli, G.; Vinci, M.; Kleinman, C. L.; Jabado, N.; Chandler, J. P.; Sonabend, A. M.; DeCuypere, M.; Hambardzumyan, D.; Prolo, L. M.; Mahaney, K. B.; Grant, G. A.; Petritsch, C. K.; Welch, J. D.; Sart
10.1101/2023.06.13.544658 — cancer biology — Posted on 2025-02-05
4356 BTS: scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across omics data
Kuksa, P. P.; Ionita, M.; Carter, L. J.; Cifello, J.; Clark, K.; Valladares, O.; Leung, Y. Y.; Wang, L.-S.
10.1101/2024.10.30.621077 — bioinformatics — Posted on 2025-02-05
4359 Exploring Mechanisms of Action in Combinatorial Therapies through Solubility Alterations: Advancing AML Treatment
Gholizadeh, E.; Zangene, E.; Vadadokhau, U.; Ritz, D.; Soliymani, R.; Miettinen, J. J.; Baumann, M.; Wilhelm, M.; Heckman, C. A.; Saei, A. A.; Jafari, M.
10.1101/2024.11.08.618644 — biochemistry — Posted on 2025-02-05
4361 Dynamic evolution of satellite DNAs drastically differentiates the genomes of Tribolium sibling species
Veseljak, D.; Despot-Slade, E.; Volaric, M.; Horvat, L.; Vojvoda Zeljko, T.; Mestrovic, N.; Mravinac, B.
10.1101/2024.12.02.626372 — genomics — Posted on 2025-02-05
4362 Engineering elephant models of cold-adaptation and cancer resistance
Karpinski, E.; Badey, N.; Mintzer, E.; Ashkenazy-Titelman, A.; Li, L.; Church, G. M.
10.1101/2024.09.07.611789 — genetics — Posted on 2025-02-05
4363 Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk
Khouri-Farah, N.; Winchester, E. W.; Schilder, B. M.; Robinson, K.; Curtis, S. W.; Skene, N. M.; Leslie-Clarkson, E.; Cotney, J.
10.1101/2025.01.18.633396 — developmental biology — Posted on 2025-02-05
4364 Predicting Organoid Morphology Through a Phase Field Model: Insights into Cell Division and Lumenal Pressure
Tanida, S.; Fuji, K.; Lu, L.; Guyomar, T.; Lee, B. H.; Honigmann, A.; Grapin-Botton, A.; Riveline, D.; Hiraiwa, T.; Nonomura, M.; Sano, M.
10.1101/2024.04.22.590518 — cell biology — Posted on 2025-02-05
4367 2-deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat
Boehm-Sturm, P.; Schuenke, P.; Foddis, M.; Mueller, S.; Koch, S. P.; Beard, D. J.; Holloway, P.; Mottahedin, A.; Schroeder, L.; Buchan, A. M.; Mergenthaler, P.
10.1101/2025.01.08.628135 — neuroscience — Posted on 2025-02-05
4370 PROTRIDER: Protein abundance outlier detection from mass spectrometry-based proteomics data with a conditional autoencoder
Scheller, I.; Klaproth-Andrade, D.; Loipfinger, S.; Mertes, C.; Smirnov, D.; Prokisch, H.; Yepez, V.; Gagneur, J.
10.1101/2025.02.01.636024 — bioinformatics — Posted on 2025-02-05
4373 Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers
Najia, M. A.; Jha, D. K.; Zhang, C.; Laurent, B.; Schuster-Kubaczka, C.; Markel, A.; Li, C.; Morris, V.; Tompkins, A.; Hensch, L.; Qin, Y.; Chapuy, B.; Huang, Y.-C.; Morse, M.; Marunde, M.; Vaidya, A.; Gillespie, Z.; Howard, S.; North, T.; Dominguez, D.; Keogh, M.-C.; Schlaeger, T.; Shi, Y.; Li, H.; Shipp, M.; Blainey, P.; Daley, G. Q.
10.1101/2025.01.31.635709 — genomics — Posted on 2025-02-05
4375 Sialidases derived from Gardnerella vaginalis remodel the sperm glycocalyx and impair sperm function
Dohadwala, S.; Shah, P.; Farrell, M. K.; Politch, J.; Marathe, J.; Costello, C. E.; Anderson, D. J.
10.1101/2025.02.01.636076 — immunology — Posted on 2025-02-05
4377 CiFi: Accurate long-read chromatin conformation capture with low-input requirements
McGinty, S. P.; Kaya, G.; Sim, S. B.; Corpuz, R. L.; Quail, M. A.; Lawniczak, M. K.; Geib, S. M.; Korlach, J.; Dennis, M. Y.
10.1101/2025.01.31.635566 — genomics — Posted on 2025-02-05
4378 Genetic diversity and conservation insights for the baobab Adansonia suarezensis in northern Madagascar: a whole genome SNP analysis
Hariveloniaina Morilline, O.; La Montagna, D.; Attorre, F.; Rondoni, E.; Buttarazzi, F.; Andriaharimalala, T.; Ishikawa, N.; Suyama, Y.; Parducci, L.
10.1101/2025.01.31.635890 — genetics — Posted on 2025-02-05
4380 PatientProfiler: A network-based approach to personalized medicine
Lombardi, V.; Di Rocco, L.; Meo, E.; Venafra, V.; Di Nisio, E.; Perticaroli, V.; Nicolaeasa, M. L.; Cencioni, C.; Spallotta, F.; Negri, R.; Sacco, F.; Perfetto, L.
10.1101/2025.01.31.635886 — systems biology — Posted on 2025-02-05
4382 High LET Radiation: A Novel Strategy to Overcome Tumor Microtubes -Mediated Radioresistance in Glioblastoma
Dokic, I.; Ciamarone, F.; Hoffmann, D.; Bojcevski, J.; Krunic, D.; Tessonnier, T.; Winkler, F.; Debus, J.; Venkataramani, V.; Mairani, A.; Wick, W.; Abdollahi, A.
10.1101/2025.01.31.635916 — cancer biology — Posted on 2025-02-05
4394 Neural correlates of boundary extension during visual imagination
Vickery, T. J.; Singh, B.; Levy, A.; Sweetman, K.; Cronin, Z.; Intraub, H.
10.1101/2025.01.31.635941 — neuroscience — Posted on 2025-02-05
4400 Oscillatory impact of Transcranial Magnetic Stimulation at very weak-intensity on the primary motor cortex: A TMS-EEG study in the human brain
Corominas-Teruel, X.; Bracco, M.; Lohof, A.; Sherrard, R.; Colomina, M. T.; Mahon, S.; Charpier, S.; Valero-Cabre, A.
10.1101/2025.02.04.636500 — neuroscience — Posted on 2025-02-05
4401 Long-term effects of xenotransplantation of human enteric glia in immunocompetent rats with brain injury
Colitti, N.; Rice, E.; Desmoulin, F.; Combeau, M.; Parny, M.; Robert, L.; Buscail, E.; Bournet, B.; Vergnolle, N.; Raymond-Letron, I.; Loubinoux, I.; Cirillo, C.
10.1101/2024.11.15.623633 — neuroscience — Posted on 2025-02-05
4405 Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation
Woodworth, K. E.; Froom, Z. S. C. S.; Osborne, N. D.; Rempe, C. N.; Wheeler, B.; Medd, K.; Callaghan, N. I.; Qian, H.; Acharya, A. P.; Charron, C.; Huyer, L. D.
10.1101/2025.01.30.635692 — bioengineering — Posted on 2025-02-05
4408 Leopard Cats Occupied Human Settlements in China for 3,500 years before the Arrival of Domestic cats in 600-900 CE around the Tang Dynasty
Han, Y.; Hu, S.; Liu, K.; Xu, X.; Doherty, S.; Jamieson, A. E.; Manin, A.; Martins, S. G.; Yang, M.; Yu, C.; Wang, J.; Wu, Z.; Chen, C.; Han, S.; Lu, D.; Peng, L.; Wu, X.; Li, Z.; Fan, W.; Cai, Q.; Cui, Z.; Yuan, J.; Li, Z.; Liu, Y.; Li, Z.; Liu, Z.; Ma, Q.; Shao, J.; Sun, Z.; Xing, F.; Yang, W.; Yang, S.; Yue, L.; Zhang, P.; Wang, W.; Zhang, H.; Zhuang, Y.; Sun, X.; Pan, Y.; Wu, X.; Frantz, L. A. F.; Yu, H.; Alves, J. M.; Larson, G.; Luo, S.
10.1101/2025.01.31.635809 — evolutionary biology — Posted on 2025-02-05
4410 Continuum architecture dynamics of vesicle tethering in exocytosis
Puig-Tinto, M.; Ortiz Giron, J. S.; Meek, S.; Coray, R.; Hernandez, A. C.; Castellet, A.; Kramer, E.; Betancur, L.; Hoess, P.; Mund, M.; Izquierdo-Serra, M.; Oliva, B.; de Marco, A.; Ries, J.; Castano-Diez, D.; Manzo, C.; Gallego, O.
10.1101/2025.02.05.635468 — cell biology — Posted on 2025-02-05
4411 The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
Chamma, H.; Guha, S.; Schussler, M.; Messaoud-Nacer, Y.; Le Hars, P.; Salma, M.; McKellar, J.; Re, J.; Chemarin, M.; Carrier, A.; Disyak, M. A.; Taffoni, C.; Husson, Z.; Valjent, E.; Andrieu-Soler, C.; Soler, E.; Majzoub, K.; Vila, I. K.; Laguette, N.
10.1101/2025.01.30.635818 — immunology — Posted on 2025-02-05
4420 Optical Brain Pulse Monitoring for Detection of Large Vessel Occlusion Stroke in a Sheep Model
Sharkey, J. M.; Teo, E.; Chung, S. W.; Grace, S. A.; Hellerstedt, J.; Petautschnig, S.; Prag, H. A.; Turner, R. J.; Krieg, T.; Murphy, M. P.; Sorby-Adams, A.; Dixon, B.
10.1101/2025.01.30.635815 — physiology — Posted on 2025-02-05
4424 Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment
Ajaib, S.; Pollock, S.; Hemmings, G.; Gusnanto, A.; Chakrabarty, A.; Ismail, A.; Wilson, E.; Hunter, B.; Filby, A.; McDonald, D.; Brockman, A.; Ihrie, R. A.; Stead, L. F.
10.1101/2025.01.31.635832 — cancer biology — Posted on 2025-02-05
4425 Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity
Lunavat, T. R.; Nieland, L.; Looij, S. M. v. d.; Reus, A. J. E. M. d.; Couturier, C. P.; Farran, C. A. E.; Miller, T. E.; Lill, J. K.; Schubel, M.; Xiao, T.; Ianni, E. D.; Woods, E. C.; Sun, Y.; Ramos, D. R.; Solinge, T. S. v.; Mahjoum, S.; Grandell, E.; Li, M.; Mangena, V.; Dunn, G. P.; Jenkins, R. W.; Mempel, T. R.; Breakefield, X. O.; Breyne, K.
10.1101/2025.02.03.636330 — cancer biology — Posted on 2025-02-05
4426 The distortion-push mechanism for the γ-subunit rotation in F1-ATPase
Motohashi, M.; Oide, M.; Kobayashi, C.; Jung, J.; Muneyuki, E.; Sugita, Y.
10.1101/2025.02.03.636200 — biophysics — Posted on 2025-02-05
4427 Identification of High-Risk Cells in Single-Cell Spatially Resolved Transcriptomics Data Using Deep Transfer Learning
Chatterjee, D.; Couetil, J. L.; Liu, Z.; Dong, T.; Huang, K.; Chen, C.; Zhang, J.; Kalwat, M. A.; Johnson, T. S.
10.1101/2025.01.30.635803 — bioinformatics — Posted on 2025-02-05
4429 GenomeOcean: An Efficient Genome Foundation Model Trained on Large-Scale Metagenomic Assemblies
Zhou, Z.; Riley, R.; Kautsar, S.; Wu, W.; Egan, R.; Hofmeyr, S.; Goldhaber-Gordon, S.; Yu, M.; Ho, H.; Liu, F.; Chen, F.; Morgan-Kiss, R.; Shi, L.; Liu, H.; Wang, Z.
10.1101/2025.01.30.635558 — bioinformatics — Posted on 2025-02-05
4430 MeTrEx: Membrane Trajectory Explorer
Jaeger-Honz, S.; Rohse, C.; Ehrmann, B.; Klein, K.; Zhang, Y.; Ma, W.; Hamada, Y.; Li, J.; Schreiber, F.
10.1101/2025.01.31.634501 — bioinformatics — Posted on 2025-02-05
4435 Reconstructing Sordida subcomplex (Hemiptera, Reduviidae, Triatominae) phylogeny across species distribution range
Burgueno-Rodriguez, G.; Nattero, J.; Rios, N.; Piccinali, R. V.; Carbajal-de-la-Fuente, A. L.; Panzera, F.; Sansoni-Ruidiaz, B. A.; Lopes, C. M.; Lobbia, P. A.; Rojas-de-Arias, A.; Cavallo, M. J.; Rodriguez, C. S.; Lorite, P.; Vega-Gomez, M. C.; Rolon, M.; Pita, S.
10.1101/2025.01.30.635797 — genetics — Posted on 2025-02-05
4436 Short-term management of kelp forests for marine heatwaves requires pre-emptive action
Hopf, J. K.; Giraldo-Ospina, A.; Caselle, J. E.; Kroeker, K. J.; Carr, M. H.; Botsford, L. W.; Hastings, A.; White, J. W.
10.1101/2025.01.30.634607 — ecology — Posted on 2025-02-05
4437 Effects of frugivore species pool and seed size on the diversity and functional composition of frugivores visiting fruiting trees
Naniwadekar, R.; Gopal, A.; Mandal, R.; Jayanth, A.; Sriprasertsil, V.; Page, N.; Ghuman, S.; Chaplod, S.; Lad, H.; Gadkari, A.; Chandran, V. M.; Desai, N.; Kadam, R.; Strange, B. C.; Chimchome, V.; Gale, G. A.; Joshi, J.
10.1101/2025.01.31.635888 — ecology — Posted on 2025-02-05
4438 Lessons learned from applying eDNA surveying to diadromous fish detection across the north-east Atlantic region
Bhendarkar, M.; Claver, C.; Mendibil, I.; Fraija-Fernandez, N.; Nachon, D. J.; Davison, P. I.; Ba?i?, T.; O'Leary, C.; Roche, W. K.; Azpiroz, I.; Acolas, M.-L.; Lekuona, A.; Ardaiz, J.; Diaz, E.; Lambert, P.; Lassalle, G.; Rodriguez-Ezpeleta, N.
10.1101/2025.01.31.635873 — ecology — Posted on 2025-02-05
4441 Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation
Hotani, T.; Goto, M.; Otsuki, Y.; Matsuda, S.; Wada, N.; Shinohara, M.; Matsuda, T.; Yokoi, M.; Sugasawa, K.; Ohsaki, Y.; Sakai, W.
10.1101/2025.02.05.636583 — cell biology — Posted on 2025-02-05
4442 Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation in the brain and periphery
Huang, S.; Patkar, O. L.; Schulze, S.; Carter-Cusack, D.; Millard, S.; Ranpura, G.; Green, E. K.; Maxwell, E.; Cowin, G.; Stimson, D.; Kurniawan, N. D.; Keshvari, S.; Allavena, R.; Pettit, A.; Irvine, K. M.; Hume, D. A.
10.1101/2025.01.30.635395 — immunology — Posted on 2025-02-05
4443 HSP70 is a chaperone for IL-33 secretion and function in chronic airway disease
Osorio, O. A.; Kluender, C. E.; Raphael, H. E.; Hassan, G. F.; Cohen, L. S.; Steinberg, D.; Payne, M. D.; Luo, E. M.; Hicks, J. L.; Katz-Kiriakos, E.; Byers, D. E.; Alexander-Brett, J.
10.1101/2025.01.30.635799 — immunology — Posted on 2025-02-05
4444 MDSC depletion during immunization with heat-killed Mycobacterium tuberculosis increases protection against BCG infection.
Aintablian, A.; Alattar, H.; Cyran, L.; Schoen, C.; Du Plessis, N.; Walzl, G.; Schaible, U.; Nieuwenhuizen, N. E.; Lutz, M. B.
10.1101/2025.01.31.635639 — immunology — Posted on 2025-02-05
4445 The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep
Basha, D.; Azarmehri, A.; Proulx, E.; Chauvette, S.; Ghorbani, M.; Timofeev, I.
10.1101/2023.09.12.557350 — neuroscience — Posted on 2025-02-05
4448 Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions
Ning, B.; Chiu, D. J.; Pfefferkorn, R. M.; Kefella, Y.; Kane, E.; Reyes-Ortiz, V.; Liu, G.; Zhang, S.; Liu, H.; Sultan, L.; Green, E.; Constant, M.; Spira, A. E.; Campbell, J. D.; Reid, M. E.; Varelas, X.; Burks, E. J.; Lenburg, M. E.; Mazzilli, S. A.; Beane, J. E.
10.1101/2025.02.03.636307 — cancer biology — Posted on 2025-02-05
4449 Structural Diversity of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling
Marx, D. C.; Gonzalez-Hernandez, A. J.; Huynh, K.; Strauss, A.; Rico, C.; Siepe, D.; Gallo, P.; Lee, J.; Sharghi, S.; Arefin, A.; Broichhagen, J.; Eliezer, D.; Kalocsay, M.; Khelashvili, G.; Levitz, J.
10.1101/2025.02.03.636340 — biophysics — Posted on 2025-02-05
4450 Photomodulation of Kv Channel Activity
Yadav, R.; Pfeffermann, J.; Goessweiner-Mohr, N.; Glasnov, T.; Akimov, S. A.; Pohl, P.
10.1101/2025.02.04.636384 — biophysics — Posted on 2025-02-05
4453 HIDE: Hierarchical cell-type Deconvolution
Völkl, D.; Mensching-Buhr, M.; Sterr, T.; Bolz, S.; Schäfer, A.; Seifert, N.; Tauschke, J.; Rayford, A.; Straume, O.; Zacharias, H. U.; Grellscheid, S. N.; Beissbarth, T.; Altenbuchinger, M.; Görtler, F.
10.1101/2025.01.31.634483 — bioinformatics — Posted on 2025-02-05
4455 Clustered VEGF Nanoparticles in Microporous Annealed Particle (MAP) Hydrogel Accelerates Functional Recovery and Brain Tissue Repair after Stroke
Erning, K.; Wilson, K. L.; Smith, C. S.; Nguyen, L.; Joseph, N. I.; Irengo, R.; Cao, L. Y.; Cumaran, M.; Shi, Y.; Lyu, S.; Riley, L.; Dunn, T. W.; Carmichael, S. T.; Segura, T.
10.1101/2025.01.30.635733 — bioengineering — Posted on 2025-02-05
4456 Micro-invasive probes for monitoring electrical and chemical neural activity in nonhuman primates
Amjad, U.; Mahajan, S.; Choi, J.; Shrivastav, R.; Murray, R.; Somich, A.; Coyne, O.; Schwerdt, H. N.
10.1101/2025.01.30.635139 — bioengineering — Posted on 2025-02-05
4458 Solubilization of Membrane Proteins using designed protein WRAPS
Mihaljevic, L.; Kim, D. E.; Eisenach, H. E.; Bandawane, P. D.; Borst, A. J.; Courbet, A.; Bettin, E.; Liu, Q.; Weidle, C.; Majumder, S.; Li, X.; Lamb, M.; Azcarraga Murray, A. N.; Ravichandran, R.; Williams, E. C.; Hu, S.; Stuart, L.; Grillova, L.; Thomson, N. R.; Chang, P.; Caimano, M. J.; Hawley, K. L.; King, N. P.; Baker, D.
10.1101/2025.02.04.636539 — biochemistry — Posted on 2025-02-05
4459 Heterochromatin boundaries maintain centromere position, size and number
Carty, B. L.; Dubocanin, D.; Murillo-Pineda, M.; Dumont, M.; Volpe, E.; Mikulski, P.; Humes, J.; Whittingham, O.; Fachinetti, D.; Giunta, S.; Altemose, N.; Jansen, L. E. T.
10.1101/2025.02.03.635667 — genomics — Posted on 2025-02-05
4461 Maturation-dependent complement production and C3 processing in human retinal pigment epithelium cells
Schikora, J.; Nickel, A.; Bergert, J.; Hähnel, R.; Dort, A.; Schayan-Araghi, S. Y.; Banerjee, P.; Wolf, H. N.; May-Simera, H. L.; Pauly, D.
10.1101/2025.02.05.636432 — cell biology — Posted on 2025-02-05
4462 Treatment of human oocytes with extracellular vesicles from follicular fluid during rescue in vitro maturation enhances maturation rates and modulates oocyte proteome and ultrastructure
Makieva, S.; Saenz-de-Juano, M. D.; Alminana, C.; Bauersachs, S.; Bernal-Ulloa, S.; Xie, M.; Velasco Gil, A.; Cervantes Gomez, N.; Sachs, M.; Ulbrich, S. E.; Leeners, B.
10.1101/2025.02.05.636623 — cell biology — Posted on 2025-02-05
4464 Remote Cortical Network for Frontal Cognitive Symptoms derived from Tau Accumulation in Progressive Supranuclear Palsy
Hori, Y.; Endo, H.; Tagai, K.; Kataoka, Y.; Goto, R.; Kurose, S.; Momota, Y.; Kokubo, N.; Seki, C.; Moriguchi, S.; Shimada, H.; Shinotoh, H.; Tokuda, T.; Takahata, K.; Minamimoto, T.; Higuchi, M.; Hirabayashi, T.
10.1101/2025.02.05.636578 — neuroscience — Posted on 2025-02-05
4466 CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays
Park, B. J.; Hua, S.; Casler, K. D.; Cefaloni, E.; Ayers, M. C.; Lake, R. F.; Murphy, K. E.; Vertino, P. M.; O'Connell, M. R.; Murphy, P. J.
10.1101/2025.02.03.636299 — genomics — Posted on 2025-02-05
4467 Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish
Vanhooydonck, M.; De Neef, E.; De Saffel, H.; Boel, A.; Willaert, A.; Callewaert, B.; Claes, K. B.
10.1101/2025.02.05.636566 — genetics — Posted on 2025-02-05
4468 The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity
Patriotis, A. L.; Soto-Feliciano, Y.; Barrows, D.; Khan, L.; Leboeuf, M.; Lund, P.; Marunde, M. R.; Djomo, A.; Keogh, M.-C.; Carroll, T.; Garcia, B.; Soshnev, A. A.; Allis, C. D.
10.1101/2025.02.04.636462 — genetics — Posted on 2025-02-05
4469 Ancient origin of an urban underground mosquito
Haba, Y.; Aardema, M. L.; Afonso, M. O.; Agramonte, N. M.; Albright, J.; Alho, A. M.; Almeida, A. P. G.; Alout, H.; Alten, B.; Altinli, M.; Amara Korba, R.; Andreadis, S. S.; Anghel, V.; Arich, S.; Arsenault-Benoit, A.; Atyame, C.; Aubry, F.; Avila, F. W.; Ayala, D.; Azrag, R. S.; Babayan, L.; Bear, A.; Becker, N.; Bega, A. G.; Bejarano, S.; Ben-Avi, I.; Benoit, J. B.; Boubidi, S. C.; Bradshaw, W. E.; Bravo-Barriga, D.; Bueno-Mari, R.; Busic, N.; Cabanova, V.; Cabeje, B.; Caputo, B.; Cardo, M. V.; Carpenter, S.; Carreton, E.; Chouaibou, M. S.; Christian, M.; Coetzee, M.; Conner, W. R.; Cornel,
10.1101/2025.01.26.634793 — evolutionary biology — Posted on 2025-02-05
4471 Master control genes in the regeneration of rod photoreceptors from endogenous progenitor cells in zebrafish retina
Shihabeddin, E.; Santhanam, A.; Tetenborg, S.; Aronowitz, A. L.; Wei, H.; Qin, G.; Cai, C.; Wu, J.; O'Brien, J.
10.1101/2025.02.03.636263 — neuroscience — Posted on 2025-02-05
4475 Mycobacterium intracellulare ABSURDO is a novel clinical isolate with three colony morphotypes that vary in pathogenicity and sequence at the PKS and MtrA loci
Claeys, T. A.; Liu, Y.; Prigodich, A.; Peck, E.; Gokul, E.; Reed-Mera, N.; Tuah, A.; Wirekoh, A.; Quinn, K. N.; Rosas Mejia, O.; Clary, G.; Sasindran, S.; Dellos-Nolan, S.; Gloag, E.; Huppler, A. R.; Hull, N. M.; Jude, B. A.; Robinson, R. T.
10.1101/2025.02.03.636325 — microbiology — Posted on 2025-02-05
4476 Reduced inter-subject functional connectivity during movies in autism: Replicability across cross-national fMRI datasets
Lin, F.; Albantakis, L.; Noppari, T.; Santavirta, S.; Brandi, M.-L.; Sun, L.; Lukkarinen, L.; Tani, P.; Salmi, J.; Nummenmaa, L.; Dukart, J.; Schilbach, L.; Lahnakoski, J. M.
10.1101/2025.02.04.636405 — neuroscience — Posted on 2025-02-05
4481 ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis
Raza, M.; Rajan, A. R.; Kennedy, B. B.; Reznicek, T. E.; Oruji, F.; Mirza, S.; Rowley, M. J.; Kristiansen, G.; Datta, K.; Mohapatra, B. C.; Band, H.; Band, V.
10.1101/2025.01.30.635534 — cancer biology — Posted on 2025-02-05
4482 Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion
Kowalewski, K. M.; Adair, S. J.; Talkington, A.; Wieder, J.; Pitarresi, J. R.; Perez-Vale, K.; Chu, B.; Dolatshahi, S.; Sears, R.; Stanger, B. Z.; Bauer, T. W.; Lazzara, M. J.
10.1101/2025.01.30.635486 — cancer biology — Posted on 2025-02-05
4484 The CFDE Workbench: Integrating Metadata and Processed Data from Common Fund Programs
Evangelista, J. E.; Clarke, D. J. B.; Xie, Z.; Olaiya, S.; Kim, H.; Marino, G. B.; Byrd, A. I.; Srinivasan, S.; Srinivasan, S.; Maurya, M. R.; Jenkins, S. L.; Lutsky, A. D.; Sasaya, L.; Lachmann, A.; Ahmed, N.; Diamant, I.; Sanchez, E.; Ramachandran, S.; Subramaniam, S.; Ma'ayan, A.
10.1101/2025.02.04.636535 — bioinformatics — Posted on 2025-02-05
4486 Genetic basis of partner choice
Zheng, Q.; van Alten, S.; Lyngstad, T. H.; Ciscato, E.; Sun, Z.; Miao, J.; Wu, Y.; Dorn, S.; Zheng, B.; Havdahl, A.; Corfield, E. C.; Nivard, M.; Galama, T. J.; Turley, P.; Chiappori, P.-A.; Fletcher, J. M.; Lu, Q.
10.1101/2025.02.03.636375 — genetics — Posted on 2025-02-05
4489 Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity
Meneses-Salas, E.; Arnold, M.; Castella, M.; Hsieh, F.; Fernandez-Santiago, R.; Ezquerra, M.; Garrido, A.; Marti, M. J.; Enrich, C.; Pfeffer, S. R.; Merchant, K. M.; Lu, A.
10.1101/2023.07.12.548710 — cell biology — Posted on 2025-02-05
4490 Picoplankton nitrogen guilds in the tropical and subtropical oceans: from the surface to the deep
Rivas-Santisteban, J.; Fernandez-Gonzalez, N.; Laso-Perez, R.; Tamames, J.; Pedros-Alio, C.
10.1101/2024.03.05.583471 — microbiology — Posted on 2025-02-05
4493 Lipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates.
Mangiarotti, A.; Sabri, E.; Schmidt, K. V.; Hoffmann, C.; Milovanovic, D.; Lipowsky, R.; Dimova, R.
10.1101/2024.07.15.603610 — biophysics — Posted on 2025-02-05
4494 Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels
Chevalier, M.; Fadel, F.; Majer, T.; Magda, D. P.; Gerendas, L.; Kilin, F.; Nagy, Z. Z.; Szabo, A.; Roska, B.; Testa-Silva, G.
10.1101/2025.01.08.631889 — bioengineering — Posted on 2025-02-05
4495 Inferring internal states across mice and monkeys using facial features
Tlaie, A.; Abd El Hay, M. Y.; Mert, B.; Taylor, R.; Ferracci, P. A.; Shapcott, K. A.; Glukhova, M.; Pillow, J. W.; Havenith, M. N.; Scholvinck, M.
10.1101/2024.01.24.577055 — animal behavior and cognition — Posted on 2025-02-05
4497 Farming with Alternative Pollinators for Increased Biodiversity and Smallholder Incomes in Zimbabwe
Allebone-Webb, S.; Gossau, F.; Orland, C.; Bara, G.; Fioekou, C.; Matsika, A.; Riber, K.; Mahaman Dioula, B.
10.1101/2024.11.29.626070 — ecology — Posted on 2025-02-05
4499 Vγ1+ γδ T cell-derived IL-4 initiates CD8 T cell immunity
Le, S.; Murphy, D.; Liu, S.; Ge, Z.; May, R.; Cozijnsen, A.; Burn, T.; Jennison, C.; Bachem, A.; Xu, C.; Koay, H.-F.; Schroeder, J.; Gras, S.; Cockburn, I. A.; Bedoui, S.; Mackay, L. K.; Mcfadden, G. I.; Fernandez-Ruiz, D.; Heath, W. R.; Beattie, L.
10.1101/2024.12.06.627130 — immunology — Posted on 2025-02-05
4502 EEG Dynamical Features during Variable-Intensity Cycling Exercise in Parkinson's Disease
Alizadeh, Z.; Arasteh, E.; Mirian, M. S.; Sacheli, M.; Murray, D.; Cresswell, S.; McKeown, M.
10.1101/2025.01.15.633102 — neuroscience — Posted on 2025-02-05
4505 Structural variation, selection, and diversification of the NPIP gene family from the human pangenome
Dishuck, P. C.; Munson, K. M.; Lewis, A. P.; Dougherty, M. L.; Underwood, J. G.; Harvey, W. T.; Hsieh, P.; Pastinen, T.; Eichler, E. E.
10.1101/2025.02.04.636496 — genomics — Posted on 2025-02-05
4508 Evolution of developmental bias explains divergent patterns of phenotypic evolution
Osorio, J. P.; Bouleau, C.; Gonzalez de la Rosa, P.; Stevens, L.; Fekonja, N.; Blaxter, M.; Braendle, C.; Felix, M.-A.
10.1101/2025.02.04.636455 — evolutionary biology — Posted on 2025-02-05
4509 Dynamic Proximal Interactomics and Chemical Genetic Screening Reveal CCR4-NOT Sequestration in Stress Granules as a Mechanism for Transcript Stabilization
Tsai, Y.-C.; Uechi, H.; Millar, S. R.; Kadijk, E.; Schreiber, K. J.; Minkovich, A.; Huang, J. Q.; Zhang, Z.; Barsacchi, R.; Möbius, C.; Janosch, A.; Savage, J. C.; Röst, H.; Hyman, A. A.; Youn, J.-Y.
10.1101/2025.02.04.636058 — cell biology — Posted on 2025-02-05
4510 Anti-resonance in developmental signaling regulates cell fate decisions
Rosen, S. J.; Witteveen, O.; Baxter, N.; Lach, R. S.; Bauer, M.; Wilson, M. Z.
10.1101/2025.02.04.636331 — cell biology — Posted on 2025-02-05
4511 SAMHD1 Knockout iPSC model enables high lenti-viral transduction in myeloid cell types
Li, H.; Afroze, M.; Arora, G.; Federman, S.; Shevade, K.; Yang, Y. A.; Nguyen, P.; Esanov, R.; Przybyla, L.; Litterman, A.; Shafer, S.
10.1101/2025.02.04.636295 — cell biology — Posted on 2025-02-05
4512 A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Rodriguez-Correa, E.; Gruenschlaeger, F.; Nizharadze, T.; Anstee, N.; Al-Sabah, J.; Kumpost, V.; Sedlmeier, A.; Li, C.; Ball, M.; Fotopoulou, F.; Jayarajan, J.; Ghezzi, I.; Knoch, J.; Druce, M.; Aurich, T.; Buechler-Schaeff, M.; Lux, S.; Hernandez-Malmierca, P.; Graesel, J.; Vonficht, D.; Mathioudaki, A.; Zaugg, J. B.; Mikut, R.; Trumpp, A.; Hoefer, T.; Huebschmann, D.; Haas, S.; Milsom, M. D.
10.1101/2025.02.04.636388 — cell biology — Posted on 2025-02-05
4513 Critical Evaluation of Sphingolipids Detection by MALDI-MSI
Chen, B.; Pathak, R.; Subekti, A.; Cheng, X.; Singh, S.; Ostermeyer-Fay, A. G.; Hannun, Y. A.; Luberto, C.; Canals, D.
10.1101/2025.02.04.636486 — cell biology — Posted on 2025-02-05
4516 Distinct Structural Connectivity Patterns Associated with Variations in Language Lateralisation
Andrulyte, I.; Zago, L.; Jobard, G.; LEMAITRE, H.; Rheault, F.; Keller, S. S.; Petit, L.
10.1101/2025.02.04.636415 — neuroscience — Posted on 2025-02-05
4517 Developmental Variations in Recurrent Spatiotemporal Brain Propagations from Childhood to Adulthood
Byeon, K.; Park, H.; Park, S.; Cluce, J.; Mehta, K.; Cieslak, M.; Cui, Z.; Hong, S.-J.; Chang, C.; Smallwood, J.; Satterthwaite, T. D.; Milham, M. P.; Xu, T.
10.1101/2025.02.04.635765 — neuroscience — Posted on 2025-02-05
4519 Training Generalized Segmentation Networks with Real and Synthetic Cryo-ET data.
Purnell, C.; Heebner, J.; Nguyen, L. T.; Swulius, M. T.; Hylton, R.; Kabonick, S.; Grillo, S.; Grillo, M.; Grigoryev, S.; Heberle, F. A.; Waxham, N.; Swulius, M. T.
10.1101/2025.01.31.635598 — cell biology — Posted on 2025-02-04
4520 IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy
Castelli, S.; Wilson, W. V.; Uslu, U.; Finck, A.; Assenmacher, C.-A.; Atoche, S. J.; Siurala, M.; Young, R. M.; June, C. H.
10.1101/2025.01.30.635582 — immunology — Posted on 2025-02-04
4521 A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis
Wendt, S.; Lin, A. J.; Ebert, S. N.; Brennan, D. J.; Cai, W.; Bai, Y.; Sorrentino, S.; Groten, C. J.; Lee, C.; Frew, J.; Choi, H. B.; Karamboulas, K.; Delhaye, M.; MacKenzie, I.; Kaplan, D. R.; Miller, F.; MacVicar, B. A.; Nygaard, H. B.
10.1101/2024.07.01.601570 — neuroscience — Posted on 2025-02-04
4524 Directed evolution of a plant immune receptor for broad spectrum recognition of pathogen effectors
Rim, E. Y.; Garrett, O. D.; Howard, A. J.; Shim, Y.; Li, Y.; Van Dyke, J. E.; Packer, R. C.; Ho, N.; Jain, R. S.; Stewart, V. J.; Dinesh-Kumar, S. P.; Notwell, J. H.; Ronald, P. C.
10.1101/2024.09.30.614878 — plant biology — Posted on 2025-02-04
4525 The lower jaw of Devonian ray-finned fishes (Actinopterygii): anatomy, relationships, and functional morphology
Igielman, B.; Figueroa, R. T.; Higgins, R.; Pierce, S. E.; Coates, M. I.; Troyer, E. M.; Fernandez, V.; Dollman, K.; Lu, J.; Zhu, M.; Friedman, M.; Giles, S.
10.1101/2025.01.30.635695 — paleontology — Posted on 2025-02-04
4527 ComputAgeBench: Epigenetic Aging Clocks Benchmark
Kriukov, D.; Efimov, E.; Kuzmina, E. A.; Dudkovskaia, A.; Khrameeva, E. E.; Dylov, D. V.
10.1101/2024.06.06.597715 — bioinformatics — Posted on 2025-02-04
4528 The Rodent Electronic Nicotine Delivery System: Apparatus for Voluntary Nose-Only E-Cigarette Aerosol Inhalation
Odum, A. L.; Willis-Moore, M. E.; Callister, K. T.; Haynes, J. M.; Frye, C. C. J.; Scribner, L. N.; Legaspi, D. N.; Da Silva, D. S.; Olsen, A. L.; Truscott, T. T.; Alden, P. T.; Bevins, R. A.; Leventhal, A. M.; Lee, S. T.; Gomer, B.; Benninghoff, A. D.
10.1101/2024.12.21.629932 — animal behavior and cognition — Posted on 2025-02-04
4530 TLR4 competence and mouse models of leptospirosis
Abil, O. Z.; Kundu, S.; Midon, L. M.; Gomes-Solecki, M.
10.1101/2025.02.03.636333 — microbiology — Posted on 2025-02-04
4531 Hypothalamic prostaglandins facilitate recovery from hypoglycemia but exacerbate recurrent hypoglycemia in mice
Abe, T.; Xu, S.; Sugiura, Y.; Arima, Y.; Hayasaka, T.; Lee, M.-L.; Ishimoto, T.; Araki, Y.; Niu, Z.; IIjima, N.; Diano, S.; Toda, C.
10.1101/2024.06.24.600540 — neuroscience — Posted on 2025-02-04
4533 Impaired Macrophage DNase Secretion Promotes Neutrophil Extracellular Trap Mediated Defective Efferocytosis in Atherosclerosis
Dhawan, U. K.; Vartak, T.; Englert, H.; Singhal, A.; Chakraborty, R.; Bhagat, K. K.; Vasconcellos, L. R. C.; McDonnell, C.; Connolly, M.; Mulkern, E.; O Donohoe, M.; Gelderblom, M.; Renne, T.; Godson, C.; Brennan, E.; Subramanian, M.
10.1101/2025.01.30.635503 — pathology — Posted on 2025-02-04
4535 Recolonisation strategies of early animals in the Avalon (Ediacaran 574 - 560 Ma)
Stephenson, N. P.; Delahooke, K. M.; Buma-at, P. A.; Rideout, B. W. T.; Barnes, N.; Kenchington, C. G.; Manica, A.; Mitchell, E. G.
10.1101/2025.01.30.635654 — ecology — Posted on 2025-02-04
4536 Murine norovirus allosteric escape mutants mimic gut activation.
Sherman, M. B.; Smith, H. Q.; Cox, F.; Wobus, C. E.; Lynch, G. C.; Pettitt, B. M.; Smith, T. J.
10.1101/2025.02.04.636510 — microbiology — Posted on 2025-02-04
4538 Identification of actionable targeted protein degradation effector sites through Site-specific Ligand Incorporation-induced Proximity (SLIP)
Tate, E. W.; Xiao, Z.; Gavriil, E. S.; Cao, F.; Zhang, X.; Li, S. X.; Kotelnikov, S.; Michalska, P.; Marte, F.; Huang, C.; Lu, Y.; Zhang, Y.; Bernardini, E.; Kozakov, D.
10.1101/2025.02.04.636303 — molecular biology — Posted on 2025-02-04
4539 Specificity and Mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system
Belukhina, S.; Saudemont, B.; Depardieu, F.; Lorthios, T.; Maviza, T. P.; Livenskyi, A.; Serebryakova, M.; Aleksandrova, M.; Ukholkina, E.; Burmistrova, N.; Sergiev, P. V.; Libiad, M.; Dubrac, S.; Barras, F.; Motorin, Y.; Marchand, V.; Hagelueken, G.; Isaev, A.; Bikard, D.; Rouillon, C.
10.1101/2025.02.04.636281 — microbiology — Posted on 2025-02-04
4540 Quorum Sensing Regulators and Non-ribosomal Peptide Synthetases Govern Antibacterial Secretions in Xenorhabdus szentirmaii
Dey, R.; alle, D. O.; Chakraborty, A.; Mayer, K. A.; Uppala, J.; Chakraborty, A.; Mirza, S.; Forst, S.; Skwor, T.; Dey, M.
10.1101/2025.02.03.636359 — microbiology — Posted on 2025-02-04
4544 Characterization of Mycobacterium tuberculosis rhodanese-like sulfurtransferase SseA and its newly identified activator Rv3284: A new pathway to exploit as a drug target?
Di Napoli, G.; Fissore, A.; Salladini, E.; Raccuia, E.; Oliaro-Bosso, S.; Ruggiero, A.; Berisio, R.; Medina, M.; Velazquez-Campoy, A.; Adinolfi, S.; Marengo, M.
10.1101/2025.02.04.636439 — biochemistry — Posted on 2025-02-04
4545 Genes and Pathways Comprising the Human and Mouse ORFeomes Display Distinct Codon Bias Signatures that Can Regulate Protein Levels
Davis, E. T.; Raman, R.; Byrne, S. R.; Ghanegolmohammadi, F.; MAthur, C.; Begley, U.; Dedon, P.; Begley, T. J.
10.1101/2025.02.03.636209 — genomics — Posted on 2025-02-04
4549 CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression
Castruita, D. S.; Han, I.; Morgan, R. C.; Carpenter, S.; Williams, B.; Chakraborty, A.; Radhakrishnan, I.; Ay, F.; Myers, S. A.; Rao, A.; Shukla, V.
10.1101/2025.02.03.636329 — molecular biology — Posted on 2025-02-04
4550 Active surveillance of cats and dogs from households with human COVID-19 cases reveals over one quarter of pets infected with SARS-CoV-2 in 2020-2021 in Texas, United States
Pauvolid-Correa, A.; Davila, E.; Auckland, L.; Zecca, I. B.; Busselman, R. E.; Tang, W.; Roundy, C. M.; Killian, M. L.; Torchetti, M. K.; Jenkins-Moore, M.; Robbe-Austerman, S.; Lantz, K.; Mozingo, K.; Tell, R.; Lim, A.; Akpalu, Y.; Fischer, R. S. B.; Ferreira, F. C.; Hamer, G. L.; Hamer, S. A.
10.1101/2025.02.03.636361 — microbiology — Posted on 2025-02-04
4552 Anti-Parasitics with a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host Cell-Mediated Killing
Pandey, A. M.; Malwal, S. R.; Valladares-Delgado, M.; Labrador-Fagundez, L.; Stella, B. G.; Diaz-Perez, L. J.; Rey-Cibati, A.; Singh, D.; Stampolaki, M.; Hong, S.; Gennis, R. B.; Kolocouris, A. D.; Benaim, G.; Oldfield, E.
10.1101/2025.02.03.636145 — microbiology — Posted on 2025-02-04
4553 Advancements in Vaccine Development : A comprehensive design of a Multi-Epitopic Immunodominant Peptide Vaccine Targeting Kyasanur Forest Disease via Reverse Vaccinology
Pillai, S. B.; Jeyachandran, A.; Pariyapurath, N. K.; Jagadibabu, S.; Rajaiah, P.; Channappa, S. K.; Pachamuthu, R. G.; Premkumar, A. A.; Jagannathan, S.
10.1101/2025.02.03.634026 — microbiology — Posted on 2025-02-04
4557 Identification of Antituberculars with Favorable Potency and Pharmacokinetics through Structure-Based and Ligand-Based Modeling
Waradpande, V.; Meng, F.; Bozan, A.; Graff, D. E.; Fromer, J. C.; Mughal, K.; Mohideen, F. K.; Shivangi, F.; Paruchuri, S.; Johnston, M. L.; Sharma, P.; Crea, T. R.; Rudraraju, R.; George, A.; Folvar, C.; Nelson, A. M.; Neiditch, M. B.; Zimmerman, M. D.; Coley, C. W.; Freundlich, J. S.
10.1101/2025.02.03.636334 — microbiology — Posted on 2025-02-04
4561 High-Throughput Antibody Neutralization Screening in Massively Parallel Droplet Arrays
Gutierrez-Gonzalez, M.; Fahad, A. S.; Delley, C. L.; Chung, C.-Y.; Jin, S.; Boyle, N.; Oliveira de Souza, M.; Pirhanov, A.; Galvez, N. M. S.; Franca, C. T.; Marglous, S.; Bhagat, E.; Vincent, D.; Neumeier, D.; Cao, Y.; Doria-Rose, N.; Reddy, S. T.; Schmidt, A. G.; Balazs, A. B.; Abate, A. R.; DeKosky, B. J.
10.1101/2025.01.31.635965 — immunology — Posted on 2025-02-04
4562 A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses
Battisti, P.; Ykema, M. R.; Kasal, D. N.; Jennewein, M. F.; Beaver, S.; Weight, A. E.; Hanson, D.; Singh, J.; Bakken, J.; Cross, N.; Fusco, P.; Archer, J.; Reed, S.; Gerhardt, A.; Julander, J. G.; Casper, C.; Voigt, E. A.
10.1101/2025.01.31.635934 — immunology — Posted on 2025-02-04
4564 Mechanistic origins of temperature scaling in the early embryonic cell cycle
Rombouts, J.; Tavella, F.; Vandervelde, A.; Phong, C.; Ferrell, J.; Yang, Q.; Gelens, L.
10.1101/2024.12.24.630245 — systems biology — Posted on 2025-02-04
4565 Generating functional plasmid origins with OriGen
Irvine, J.; Arora, J.; Martinson, J. N. V.; Patel, J. R.; Hasham, S. I.; Cress, B. F.; Rubin, B. E.
10.1101/2025.02.03.636306 — synthetic biology — Posted on 2025-02-04
4567 Self-iterative multiple instance learning enables the prediction of CD4+ T cell immunogenic epitopes
Shen, L.-C.; Zhang, Y.; Wang, Z.; Littler, D. R.; Yan, L.; Tang, J.; Rossjohn, J.; Yu, D.-J.; Song, J.
10.1101/2025.02.02.636141 — bioinformatics — Posted on 2025-02-04
4572 SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics
Trachsel-Moncho, L.; Veroni, C.; Mathai, B. J.; Lapao, A.; Singh, S.; Asp, N. T.; Schultz, S. W.; Pankiv, S.; Simonsen, A.
10.1101/2024.05.15.594320 — cell biology — Posted on 2025-02-04
4573 Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction
Koenig, A. L.; Kadyrov, F. F.; Amrute, J. M.; Yang, S.; Weinheimer, C. J.; Nigro, J. M.; Kovacs, A.; Smith, G.; Lavine, K. J.
10.1101/2023.12.24.573263 — immunology — Posted on 2025-02-04
4574 Stable Cortical Body Maps Before and After Arm Amputation
Schone, H. R.; Maimon-Mor, R. O.; Kollamkulam, M. T.; Szymanska, M. A.; Gerrand, C.; Woollard, A.; Kang, N. V.; Baker, C. I.; Makin, T. R.
10.1101/2023.12.13.571314 — neuroscience — Posted on 2025-02-04
4575 Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements
Abewe, H.; Richey, A.; Vahrenkamp, J. M.; Ginley-Hidinger, M.; Rush, C. M.; Kitchen, N.; Zhang, X.; Gertz, J.
10.1101/2024.06.12.598690 — cancer biology — Posted on 2025-02-04
4576 The WIPI homolog Atg18 binds to and tethers membranes containing phosphatidylinositol-3,4,5-triphosphate.
Noguera-Canas, F. L.; Diaz-Agustin, A.; Gavira, J. A.; Paredes, J. M.; Salto, R.; Orte, A.; Conejero-Lara, F.; Martin-Martinez, M.; Perez-Lara, F. A.
10.1101/2025.01.31.635529 — biophysics — Posted on 2025-02-04
4577 Fabrication of radiopaque, drug-loaded resorbable polymer for medical device development
Melancon, S. T.; San Valentin, E. M. D.; Bolinas, D. K. M.; Bernardino, M. R.; Mishra, A.; Canlas, G.; Chintalapani, G.; Jacobsen, M. C.; Barcena, A. J. R.; Huang, S. Y.
10.1101/2025.01.30.635738 — bioengineering — Posted on 2025-02-04
4585 rTCT: Rodent Triangle Completion Task to facilitate translational study of path integration
Duncan, S.; Rehman, S.; Segen, V.; Choi, I.; Lawrence, S.; Kalani, O.; Gold, L.; Goldman, L.; Ramlo, S.; Stickel, K.; Layfield, D.; Wolbers, T.; Tiganj, Z.; Newman, E. L.
10.1101/2025.02.04.636463 — neuroscience — Posted on 2025-02-04
4586 Targeted ubiquitination of NaV1.8 reduces sensory neuronal excitability
Tyagi, S.; Ghovanloo, M.-R.; Alsaloum, M.; Effraim, P.; Higerd-Rusli, G. P.; Dib-Hajj, F.; Zhao, P.; Liu, S.; Waxman, S. G.; Dib-Hajj, S. D.
10.1101/2025.02.04.636451 — neuroscience — Posted on 2025-02-04
4591 POLARIS is a copper-binding peptide required for ethylene signalling control in Arabidopsis.
Mudge, A. M.; Mehdi, S.; Michaels, W. E.; Oroza-Puente, B.; Shen, W.; Tomlinson, C.; Wei, W.; Hoppen, C.; Uzun, B.; Roy, D.; Hetherington, F. M.; Topping, J. F.; Sadanandom, A.; Groth, G.; Robinson, N. J.; Lindsey, K.
10.1101/2023.06.15.545071 — plant biology — Posted on 2025-02-04
4592 GIGANTEA is required for robust circadian rhythms in wheat
Taylor, L. J.; Steed, G.; Pingarron-Cardenas, G.; Wittern, L.; Hannah, M. A.; Webb, A. A.
10.1101/2024.04.19.590265 — plant biology — Posted on 2025-02-04
4595 Directionality range in Emlen funnels
Patmanidis, I.; Leberecht, B.; Fraenzle, M.; Lentink, D.; Solov'yov, I.; Mouritsen, H.
10.1101/2025.02.04.636393 — animal behavior and cognition — Posted on 2025-02-04
4598 Ectopic head regeneration after nervous system ablation in a sea anemone
Mazloumi Gavgani, F.; Kraus, J. E. M.; November, J.; Al-Shaer, L.; Seybold, A. C.; Lerstad, B.; Hausen, H.; Layden, M. J.; Rentzsch, F.
10.1101/2025.02.04.636403 — developmental biology — Posted on 2025-02-04
4599 Oviductin sets the species-specificity of the mammalian zona pellucida
de la Fuente, D.; Maroto, M.; Cajas, Y. N.; Canon-Beltran, K.; Fernandez-Gonzalez, R.; Munoz-Maceda, A.; Sanchez-Puig, J. M.; Blasco, R.; Cots, P.; Aviles, M.; Rizos, D.; Gutierrez-Adan, A.
10.1101/2024.07.01.601502 — developmental biology — Posted on 2025-02-04
4601 Identification of novel plasma proteomic biomarkers of Dupuytren Disease
Hummer, B.; Sebastiani, P. J.; Gurinovich, A.; Leshchyk, A.; Bager, C.; Karsdal, M.; Nielsen, S.; Eaton, C. J.
10.1101/2024.12.13.628406 — molecular biology — Posted on 2025-02-04
4602 Integrative profiling of condensation-prone RNAs during early development
Klobucar, T.; Novljan, J.; Iosub, I. A.; Kokot, B.; Urbancic, I.; Jones, D. M.; Chakrabarti, A. M.; Luscombe, N.; Ule, J.; Modic, M.
10.1101/2024.10.14.618182 — molecular biology — Posted on 2025-02-04
4603 Novel multiparametric bulk and single extracellular vesicle pipeline for adipose cell-specific biomarker discovery in paired human biospecimens
Hade, M. D.; Greenwald, J.; Palacia, P. L.; Nguyen, K. T. K.; Shantaram, D.; Butsch, B.; Kim, Y.; Noria, S.; Brethauer, S.; Needleman, B.; Hsueh, W.; Wysocki, V.; Reategui, E.; Magana, S. M.
10.1101/2024.04.18.590172 — molecular biology — Posted on 2025-02-04
4604 Coordinated active repression operates via transcription factor cooperativity and multiple inactive promoter states in a developing organism.
Pimmett, V. L.; Douaihy, M.; Maillard, L.; Trullo, A.; Garcia Idieder, P.; Costes, M.; Dufourt, J.; Lenden-Hasse, H.; Radulescu, O.; Lagha, M.
10.1101/2024.02.05.577724 — molecular biology — Posted on 2025-02-04
4605 Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis
Tanca, A.; Schallert, K.; Grenga, L.; Peters, S. L.; Abbondio, M.; De Diego, L.; Deledda, M. A.; Haange, S.-B.; Miotello, G.; Saenz, J. S.; Wolf, M.; Bastida, F.; Devos, S.; Hernandez-Raquet, G.; Seifert, J.; Wilmes, P.; Van Den Bossche, T.; Kunath, B. J.; Heyer, R.; Jehmlich, N.; Benndorf, D.; Hettich, R. L.; Armengaud, J.; Uzzau, S.
10.1101/2025.01.31.635836 — microbiology — Posted on 2025-02-04
4606 Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility
Mowla, S.; Farahani, L.; Tharakan, T.; Davies, R.; Correia, G. D.; Lee, Y. S.; Kundu, S.; Khanjani, S.; Sindi, E.; Rai, R.; Regan, L.; Khalifa, D.; Henkel, R.; Minhas, S.; S. Dhillo, W.; Ben Nagi, J.; Bennett, P.; MacIntrye, D. A.; Jayasena, C. N.
10.1101/2024.02.18.580923 — microbiology — Posted on 2025-02-04
4609 Nora virus proliferates in dividing intestinal stem cells and sensitizes flies to intestinal infection and oxidative stress
Franchet, A.; Haller, S.; Yamba, M.; Barbier, V.; Vieira, A.; Leclerc, V.; Becker, S.; Lee, K.-Z.; Orlov, I.; Spehner, D.; Daeffler, L.; Ferrandon, D.
10.1101/2025.01.30.635658 — immunology — Posted on 2025-02-04
4611 Gray matter correlates of childhood maltreatment: searching for replicability in a multi-cohort brain-wide association study
Goltermann, J.; Winter, N. R.; Meinert, S.; Grotegerd, D.; Kraus, A.; Flinkenflügel, K.; Altegoer, L.; Krieger, J.; Leehr, E. J.; Böhnlein, J.; Bonnekoh, L. M.; Richter, M.; Hahn, T.; Fisch, L.; Gruber, M.; Hermesdorf, M.; Berger, K.; Arolt, V.; Brosch, K.; Stein, F.; Thomas-Odenthal, F.; Usemann, P.; Teutenberg, L.; Hammes, V.; Jamalabadai, H.; Alexander, N.; Straube, B.; Jansen, A.; Nenadic, I.; Kircher, T.; Opel, N.; Dannlowski, U.
10.1101/2024.08.15.608132 — neuroscience — Posted on 2025-02-04
4612 Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons
Gorgogietas, V.; Weiss, A.; Cousin, L.; Hoffmann, D.; Schmitt, K.; Ogier, A.; Barbuti, P. A.; Santos, B. F. R.; Boussaad, I.; Wittich, A.; Zaliani, A.; Pless, O.; Krueger, R.; Sommer, P.; Wilbertz, J. H.
10.1101/2024.09.19.613945 — neuroscience — Posted on 2025-02-04
4613 Spatial coding supports auditory conceptual navigation
Jasmin, K.; Bullock, M.; Dick, F.; Atkins, R.; Bottini, R.; Sigismondi, F.; Tierney, A. T.
10.1101/2025.02.04.636440 — neuroscience — Posted on 2025-02-04
4616 The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in mouse visual cortex
Jenks, K. R.; Cai, Y.; Nayan, M. E.; Tsimring, K.; Li, K.; Zepeda, J. C.; Heller, G. R.; Delepine, C.; Shih, J.; Yuan, S.; Zhu, Y.; Wang, Y.; Duan, Y.; Fu, A. K. Y.; Ku, T.; Yun, D. H.; Chung, K.; Mellios, N.; Sur, M.; Ip, J. P. K.
10.1101/2024.07.19.603416 — neuroscience — Posted on 2025-02-04
4617 A shared threat-anticipation circuit is dynamically engaged at different moments by certain and uncertain threat
Cornwell, B. R.; Didier, P. R.; Grogans, S. E.; Anderson, A. S.; Islam, S.; Kim, H. C.; Kuhn, M.; Tillman, R. M.; Hur, J.; Scott, Z. S.; Fox, A. S.; DeYoung, K. A.; Smith, J. F.; Shackman, A. J.
10.1101/2024.07.10.602972 — neuroscience — Posted on 2025-02-04
4618 Emergence of Anticipatory Beta Activity to Facilitate Behavioral Stability Following Environmental Changes
Bracco, M.; Vasudevan, V.; Rohira, V.; Welniarz, Q.; Razafinimanana, M.; Richard, A.; Gitton, C.; Meunier, S.; Valero-Cabre, A.; Schwartz, D.; Popa, T.; Gallea, C.
10.1101/2024.12.23.630078 — neuroscience — Posted on 2025-02-04
4619 Functional recovery of adult brain tissue arrested in time during cryopreservation by vitrification
German, A.; Akdas, E. Y.; Fluegel-Koch, C.; Fejtova, A.; Winkler, J.; Alzheimer, C.; Zheng, F.
10.1101/2025.01.22.634384 — neuroscience — Posted on 2025-02-04
4621 Highly potent novel multi-armoured IL13Rα2 CAR-T subverts the immunosuppressive microenvironment of Glioblastoma
Mangolini, M.; Srivastava, S.; Souster, E.; Yang, Y.; Wang, H.; Karattil, R.; Schultz, L.; Ma, B.; Pombal, D.; Greenig, M.; Ramon, A.; Sormanni, P.; Cordoba, S.; Onuoha, S.
10.1101/2025.01.10.632392 — cancer biology — Posted on 2025-02-04
4623 Comparative Extraction of Cellular Features from High-Resolution Volume Imaging
Mimori-Kiyosue, Y.; Hamaji, T.; Hayashi, A.; Okada, M.; Higasa, K.; Kiyosue, K.; Gomibuchi, Y.; Yasunaga, T.; Washio, T.; Hara, S.
10.1101/2025.02.01.636042 — bioinformatics — Posted on 2025-02-04
4626 A Drosophila model for Costello Syndrome caused by Ras mutation K117R
Karunaraj, P.; Cao, E.; Singh, H.; Luf, M.; Baker, S. J.; Reddy, E. P.; Pfleger, C. M.
10.1101/2025.02.03.635762 — developmental biology — Posted on 2025-02-04
4628 A CD25-CCR7 complex initiates non-canonical IL-2 signaling
Kim, S. H. J.; Lee, H.; Gingras, A.; Ley, K.; Spangler, J. B.; Ginsberg, M. H.
10.1101/2025.02.03.636356 — cell biology — Posted on 2025-02-04
4629 Structural Characterization of Native RNA Polymerase II Transcription Complexes and Nucleosomes in Drosophila melanogaster
Venette-Smith, N. L.; Vishwakarma, R. K.; Venkatakrishnan, V.; Dollinger, R.; Schultz, J.; Babitzke, P.; Anand, G. S.; Gilmour, D. S.; Armache, J.-P.; Murakami, K.
10.1101/2025.02.03.636274 — molecular biology — Posted on 2025-02-04
4630 Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells
Staudt, S.; Nikolka, F.; Perl, M.; Franz, J.; Leblay, N.; Yuan, X.-K.; Larrayoz, M.; Lozano, T.; Warmuth, L.; Fante, M. A.; Skorpskaite, A.; Fei, T.; Bromberg, M.; San Martin-Uriz, P.; Rodriguez-Madoz, J. R.; Ziegler-Martin, K.; Adil-Gholam, N.; Benz, P.; Tran Huu, P.; Stein-Thoeringer, C.; Schmitt, M.; Kleigrewe, K.; Freitag, F.; Riester, Z.; Weber, J.; Mangold, K.; Ho, P.; Einsele, H.; Prosper, F.; Ellmeier, W.; Busch, D.; Visekruna, A.; Slingerland, J.; Shouval, R.; Hiller, K.; Lasarte, J. J.; Martinez-Climent, J. A.; Pausch, P.; Neri, P.; van den Brink, M.; Poeck, H.; Hudecek, M.; Luu, M.
10.1101/2024.08.19.608538 — immunology — Posted on 2025-02-04
4631 Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice.
Sanchez-Leon, C. A.; Sanchez-Garrido Campos, G.; Fernandez, M.; Sanchez-Lopez, A.; Medina, J. F.; Marquez-Ruiz, J.
10.1101/2023.02.18.529047 — neuroscience — Posted on 2025-02-04
4633 Enhancing the efficiency of oncolytic vaccinia virus for ovarian cancer treatment
Drymiotou, S.; Queval, C. J.; Tyson, K. E.; Sheach, L. A.; Postigo, A.; Rosa, I. D.; Howell, M.; McNeish, I. A.; Way, M.
10.1101/2025.02.04.636413 — cancer biology — Posted on 2025-02-04
4634 An immunocompetent mouse model of liposarcoma
Shafer, A. M.; Kenna, E.; Golden, L.-A. F.; Elhossiny, A. M.; Perry, K. D.; Wilkowski, J.; Yan, W.; Kaczkofsky, B.; McGue, J.; Bresler, S. C.; Courtney, A. H.; Dalman, J. M.; Galban, C. J.; Jiang, W.; Espinoza, C. E.; Chugh, R.; Iyer, M. K.; Frankel, T. L.; Pasca di Magliano, M.; Dlugosz, A. A.; Angeles, C. V.
10.1101/2025.01.31.634916 — cancer biology — Posted on 2025-02-04
4635 A spatially resolved single cell proteomic atlas of Small Bowel Adenocarcinoma
Dereli, Z.; Bozorgui, B.; Sanchez, M.; Hornstein, N. J.; Thibault, G.; Wang, H.; Mills, G. B.; Weinstein, J. N.; Overman, M. J.; Korkut, A.
10.1101/2025.02.01.634535 — cancer biology — Posted on 2025-02-04
4637 CDK9 interacts with a RanGTP-NEMP1-Importin β complex to regulate erythroid enucleation
Newton, L. M.; Lim, K. Y.; Abeid, D. Y.; Woelwer, C. B.; Johnson, C. J.; Russell, S. M.; Hawkins, E. D.; Humbert, P. O.
10.1101/2025.02.03.636174 — cell biology — Posted on 2025-02-04
4639 White and Clearing: New Optical Tissue Clearing Method
Llorente, V.; Fernandez-Cortes, E.; Sanderson, D.; Salazar, J.; Ripoll, J.; Desco, M.; Gomez-Gaviro, M. V.
10.1101/2025.01.30.635653 — physiology — Posted on 2025-02-04
4641 Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner
Pacifico, P.; George, D.; Jayaraj, N.; Ren, D.; Coy-Dibley, J.; Belmadani, A.; Andelic, M.; Cartelli, D.; Devigili, G.; Lombardi, R.; Lauria, G.; Paller, A.; Miller, R.; Menichella, D. M.
10.1101/2025.01.30.635734 — neuroscience — Posted on 2025-02-04
4642 Deep visual multi-omics profiling reveals mechanisms that underly cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma
Bolck, H. A.; Migh, E.; Kriston, A.; Zajac, N.; Kreutzer, S.; Totu, T.; Leary, P.; Kovacs, F.; Rutishauser, D.; Pfammatter, S.; Grossmann, J.; Litchfield, C.; Buljan, M.; Rupp, N. J. A.; Horvath, P.; Moch, H.
10.1101/2025.01.31.635927 — cancer biology — Posted on 2025-02-04
4643 Conspecific brood parasitism in the barn swallow (Hirundo rustica)
Jelinek, V.; Mari, L.; Petrzelkova, A.; Albrechtova, J.; Cepak, J.; Kuhn, S.; Munclinger, P.; Tomasek, O.; Sulc, M.; Kempenaers, B.; Albrecht, T.
10.1101/2025.01.31.635828 — ecology — Posted on 2025-02-04
4644 Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition.
Daly, J. L.; Chen, K.-e.; Butkovic, R.; Guo, Q.; Healy, M. D.; Pennink, E.; Gamble-Strutt, G.; Higham, Z.; Moody, E. R. R.; Lewis, P. A.; Heesom, K. J.; Williams, T. A.; McMillan, K. J.; Collins, B. M.; Cullen, P. J.
10.1101/2025.02.04.636264 — cell biology — Posted on 2025-02-04
4646 Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
Butkovic, R.; Healy, M. D.; de Heus, C.; Walker, A. P.; Beyers, W.; McNally, K. E.; Lewis, P. A.; Heesom, K. J.; Liv, N.; Klumperman, J.; Di Pietro, S.; Collins, B. M.; Cullen, P. J.
10.1101/2025.02.04.636395 — cell biology — Posted on 2025-02-04
4647 FREQuency-resolved brain Network Estimation via Source Separation (FREQ-NESS)
Rosso, M.; Fernandez-Rubio, G.; Keller, P.; Brattico, E.; Vuust, P.; Kringelbach, M. L.; Bonetti, L.
10.1101/2024.08.28.610155 — neuroscience — Posted on 2025-02-04
4650 Ancient DNA indicates 3,000 years of genetic continuity in the Northern Iranian Plateau, from the Copper Age to the Sassanid Empire
Ala Amjadi, M.; Can Ozdemir, Y.; Ramezani, M.; Jakab, K.; Megyes, M.; Bibak, A.; Salehi, Z.; Hayatmehr, Z.; Taheri, M. H.; Moradi, H.; Zargari, P.; Hasanpour, A.; Jahani, V.; Sharifi, A. M.; Egyed, B.; Mende, B. G.; Tavallaie, M.; Szecsenyi-Nagy, A.
10.1101/2025.02.03.636298 — genomics — Posted on 2025-02-04
4652 Cross-Species Communication via Fungal Extracellular Vesicles
Piraine, R. E. A.; Oliveira, H. T.; Santos, P.; Froldi, J. L.; de Oliveira, B. T. M.; Rezende, C. P.; Trentin, G.; Nogueira, L. F.; Lopes Colombo, A.; Casadevall, A.; Rodrigues, M.; Almeida, F.
10.1101/2025.02.03.636213 — microbiology — Posted on 2025-02-04
4653 Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state
Lee, C. R.; Matthews, G. A.; Lemieux, M. E.; Wasserlein, E. M.; Borio, M.; Miranda, R. L.; Keyes, L. R.; Schneider, G. P.; Jia, C.; Tran, A.; Aloboudi, F.; Chan, M. G.; Peroni, E.; Pereira, G.; Lopez-Moraga, A.; Pall e, A.; Kimchi, E. Y.; Padilla-Coreano, N.; Wichmann, R.; Tye, K. M.
10.1101/2025.02.03.636224 — neuroscience — Posted on 2025-02-04
4654 Protocol for a minigene splice assay using the pET01 vector
Andreae, H.; Curcio, M.; Esmaeelpour, S.; Jahnke, F.; Benseler, F.; Brose, N.; Vona, B.
10.1101/2025.02.03.636202 — genetics — Posted on 2025-02-04
4656 Differential time-restricted sensitivity of enveloped viruses to Sec61 translocon blockade
Eke, L.; Hall, B.; Thorne, L.; Ebert, K.; Kerfoot, L.; Towers, G.; Simmonds, R.; Elliott, G.
10.1101/2025.02.03.636181 — microbiology — Posted on 2025-02-04
4657 A public resource of 15 genomically characterised representative strains of Shigella sonnei
Miles, S. L.; Hawkey, J.; Vezina, B.; Torraca, V.; Jenkins, C.; Weill, F.-X.; Baker, S.; Baker, K. S.; Mostowy, S.; Holt, K. E.
10.1101/2025.02.03.635664 — microbiology — Posted on 2025-02-04
4658 Lower cortical activation and altered functional connectivity characterize passive auditory spatial attention in ASD
Osorio, S.; Tan, J.; Levine, G.; Ahlfors, S. P.; Graham, S.; Mamashli, F.; Khan, S.; Joseph, R. M.; Nayal, Z.; Losh, A.; Pawlyszyn, S.; McGuiggan, N. M.; Hamalainen, M. S.; Bharadwaj, H.; Kenet, T.
10.1101/2025.01.02.631088 — neuroscience — Posted on 2025-02-04
4659 A multimodal dataset linking wide-field calcium imaging to behavior changes in mice during an operant lever-pull task
Kondo, M.; Sehara, K.; Harukuni, R.; Aoki, R.; Sugimoto, S.; Tanaka, Y. R.; Matsuzaki, M.; Nakae, K.
10.1101/2025.02.03.631599 — neuroscience — Posted on 2025-02-04
4665 A Litmus Test for Confounding in Polygenic Scores
Smith, S. P.; Smith, O. S.; Mostafavi, H.; Peng, D.; Berg, J. J.; Edge, M. D.; Harpak, A.
10.1101/2025.02.01.635985 — genomics — Posted on 2025-02-04
4667 Challenges in replicating layer-specificity of working memory processes in human dlPFC
Chaimow, D.; Degutis, J. K.; Haenelt, D.; Trampel, R.; Weiskopf, N.; Lorenz, R.
10.1101/2025.01.31.635930 — neuroscience — Posted on 2025-02-04
4672 Chromato-kinetic fingerprinting enables multiomic digital counting of single disease biomarker molecules
Banerjee, P.; Ray, S.; Dai, L.; Sandford, E.; Chatterjee, T.; Mandal, S.; Siddiqui, J.; Tewari, M.; Walter, N. G.
10.1101/2025.01.31.636009 — biophysics — Posted on 2025-02-04
4673 The WIPI homolog Atg18 binds to and tethers membranes containing phosphatidylinositol-3,4,5-triphosphate.
Noguera-Canas, F. L.; Diaz-Agustin, A.; Gavira, J. A.; Paredes, J. M.; Salto, R.; Orte, A.; Conejero-Lara, F.; Martin-Martinez, M.; Perez-Lara, F. A.
10.1101/2025.01.31.635529 — biophysics — Posted on 2025-02-04
4674 Novel Pipelines to Extract Differences in Proteome Dynamics Based on Health Status
Xu, B.; Zhao, J.; Huang, T.; Honfo, S. H.; Trumpff, C.; Picard, M.; Cohen, A.; Liu, M.
10.1101/2025.02.01.636015 — bioinformatics — Posted on 2025-02-04
4676 Discovery of Epigenetically Silenced Tumor Suppressor Genes in Aggressive Breast Cancer Through a Computational Approach
Vitte, A.-L.; Chuffart, F.; Jacquet, E.; Nika, E.; Mousseau, M.; Jung, I.; Tabone-Eglinger, S.; Bachelot, T.; Rousseaux, S.; Khochbin, S.; Bourova-Flin, E.
10.1101/2025.01.31.635071 — bioinformatics — Posted on 2025-02-04
4677 A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity
Monzel, A. S.; Devine, J.; Kapri, D.; Enriquez, J. A.; Trumpff, C.; Picard, M.
10.1101/2025.02.03.635951 — cell biology — Posted on 2025-02-04
4682 GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis
Ortega-Legarreta, A.; Maillo, A.; Mouzo, D.; Lopez-Perez, A. R.; Kular, L.; Kakhki, M. P.; Tegner, J.; Jagodic, M.; Lagani, V.; Ewing, E.; Gomez-Cabrero, D.
10.1101/2024.12.18.629178 — bioinformatics — Posted on 2025-02-03
4684 ScaleSC: A superfast and scalable single cell RNA-seq data analysis pipeline powered by GPU.
Hu, W.; Zhang, H.; Gagnon, J.; Ouyang, z.; Moroishi, Y.; Sun, Y.; Cao, S.; Zhang, B.
10.1101/2025.01.28.635256 — bioinformatics — Posted on 2025-02-03
4685 Functional biogeography of marine microbial heterotrophs
Zakem, E. J.; McNichol, J.; Weissman, J. L.; Raut, Y.; Xu, L.; Halewood, E. R.; Carlson, C. A.; Dutkiewicz, S.; Fuhrman, J. A.; Levine, N. M.
10.1101/2024.02.14.580411 — ecology — Posted on 2025-02-03
4686 Epigenetically dynamic human centromeres are maintained within a stable DNA methylation signature
Mahlke, M. A.; Lumerman, L.; Nath, P.; Chittenden, C.; Hoyt, S.; Koeppel, J.; Xu, Y.; Raphael, R.; Zaffina, K.; Hook, P. W.; Timp, W.; Miga, K. H.; Campbell, P.; O'Neill, R. J.; Altemose, N.; Nechemia-Arbely, Y.
10.1101/2025.02.03.636285 — cell biology — Posted on 2025-02-03
4690 Restoration of mitochondrial function to metabolically stressed astrocytes by fusion with mesenchymal stromal cells.
Schneider, R. T.; Dawson, R. H.; Rowe, M. R.; Komrskova, K.; Neuzil, J.; Berridge, M.; Herst, P.; McConnell, M. J.
10.1101/2025.02.03.635611 — cell biology — Posted on 2025-02-03
4692 Desmoplakin tail domain position in the desmosomal plaque is isoform dependent
Ainslie, C. M.; Patel, K.; Tran, Y. T. B.; Bharathan, N. K.; Spindler, V.; Mattheyses, A. L.
10.1101/2025.02.03.636241 — cell biology — Posted on 2025-02-03
4695 Exploring Synergies in Brain-Machine Interfaces: Compression vs. Performance
Cubillos, L. H.; Kelberman, M.; Mender, M. J.; Hite, A.; Temmar, H.; Willsey, M.; Kumar, N. G.; Kung, T. A.; Patil, P.; Chestek, C. A.; Krishnan, C.
10.1101/2025.02.03.636273 — neuroscience — Posted on 2025-02-03
4696 Estradiol promotes habituation learning via an unidentified target, bypassing the suppressive effects of established Estrogen Receptors
Hsiao, A.; Darvaux-Hubert, I.; Hicks, D.; Joux, E.; De Freitas, S.; Dracos, E.; Lize, J.; Perrichet, J.; Baas, D.; Randlett, O.
10.1101/2025.02.03.636196 — neuroscience — Posted on 2025-02-03
4698 Endoderm differentiates into a transient epidermis in the mouse perineum
Larkins, C. E.; Grunberg, D. M.; Daniels, G. M.; Feldtmann, E. J.; Cohn, M. J.
10.1101/2025.02.03.636156 — developmental biology — Posted on 2025-02-03
4699 Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development
Hernandez-Nunez, I.; Urman, A.; Zhang, X.; Jacobs, W.; Hoffman, C.; Rebba, S.; Harding, E. G.; Li, Q.; Mao, F.; Cani, A. K.; Chen, S.; Dawlaty, M. M.; Rao, R. C.; Ruzycki, P. A.; Edwards, J. R.; Clark, B. S.
10.1101/2025.02.03.636318 — developmental biology — Posted on 2025-02-03
4701 Genetic evidence: zebrafish hoxba and hoxbb clusters are essential for the anterior-posterior positioning of pectoral fins
Kikuchi, M.; Fujii, R.; Kobayashi, D.; Kawabe, Y.; Kanno, H.; Toyama, S.; Tawakkal, F.; Yamada, K.; Kawamura, A.
10.1101/2025.02.03.636262 — developmental biology — Posted on 2025-02-03
4704 The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes
Mehnert, A.-K.; Stegmaier, S.; Ramirez, C.; Magalhaes, V. G.; Siebenkotten, C.; Hu, J.; Costa, A. L.; Kirrmaier, D.; Knop, M.; Wu, X.; Tubiana, T.; Herrmann, C.; Binder, M.; Thi, V. L. D.
10.1101/2025.02.03.636239 — microbiology — Posted on 2025-02-03
4707 Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex
Swanson, M. E. V.; Tan, A. Y. S.; Tippett, L. J.; Turner, C.; Curtis, M. A.; Scotter, E.; Lashuel, H.; Dragunow, M.; Faull, R. > M.; Murray, H. C.; Singh-Bains, M. K.
10.1101/2025.02.03.636327 — neuroscience — Posted on 2025-02-03
4711 Dual-targeting strategy to repurpose Cetuximab with HFn nanoconjugates for immunotherapy of triple-negative breast cancer
Barbieri, L.; Salvioni, L.; Banfi, A.; Garbujo, S.; Fiandra, L.; Baioni, C.; Giustra, M.; Morelli, L.; Frascotti, G.; Colombo, M.; Innocenti, M.; Prosperi, D.
10.1101/2025.02.03.634255 — biochemistry — Posted on 2025-02-03
4712 Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system
Schwarz, E. M.; Noon, J. B.; Chicca, J. D.; Garceau, C.; Li, H.; Antoshechkin, I.; Ilik, V.; Pafco, B.; Weeks, A. M.; Homan, E. J.; Ostroff, G. R.; Aroian, R. V.
10.1101/2025.02.01.636063 — genomics — Posted on 2025-02-03
4714 Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq
Zhang, H.; Li, X.; Song, D.; Yukselen, O.; Nanda, S.; Kucukural, A.; Li, J. J.; Garber, M.; Walhout, A. J. M.
10.1101/2025.02.02.636107 — genomics — Posted on 2025-02-03
4716 Structural Characterization of Native RNA Polymerase II Transcription Complexes and Nucleosomes in Drosophila melanogaster
Venette-Smith, N. L.; Vishwakarma, R. K.; Dollinger, R.; Schultz, J.; Venkatakrishnan, V.; Anand, G. S.; Gilmour, D. S.; Armache, J.-P.; Murakami, K.
10.1101/2025.02.03.636274 — molecular biology — Posted on 2025-02-03
4717 Upregulation of voltage-gated potassium channels in peripheral blood mononuclear cells: a new approach to multiple sclerosis treatment
Martinez-Almeida, M. I.; Campos-Rios, A.; Freiria-Martinez, L.; Baltanas, T. R.; Amorim, D. R.; Franco, C. M. S.; Tebar, A. R.; Peleteiro, M.; Tuche, M. C.; Suarez, I. G.; Olivares, J. M.; Lamas, J. A.; Spuch, C.
10.1101/2025.02.03.636276 — molecular biology — Posted on 2025-02-03
4720 Predicting characterization of microbiome taxonomy from imaging using machine learning approaches
Niese, B.; Sweet, P.; Dinh, B. D.; Scholes, A.; LeSassier, D. S.; Ternus, K.; Contreras, L. M.; Gordon, V.
10.1101/2025.02.03.636311 — microbiology — Posted on 2025-02-03
4722 Bacteriophage purification using CIMmultus monolithic OH-column chromatography for therapeutic purposes
Echterhof, A.; Dhamaraj, T.; Blankenberg, P.; Hajfathalian, M.; Blankenberg, F.; Sacher, J.; Bollyky, P.
10.1101/2025.02.03.636326 — microbiology — Posted on 2025-02-03
4724 Accidental and Regulated Cell Death in Yeast Colony Biofilms
Netherwood, D. J.; Tam, A.; Gourlay, C. W.; Knezevic, T.; Gardner, J. M.; Jiranek, V.; Binder, B.; Green, J. E. F.
10.1101/2025.02.02.636168 — microbiology — Posted on 2025-02-03
4725 Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi
Malwal, S. R.; Garcia-Rubio, R.; Kordalewska, M.; Patterson, H.; Zhang, C.; Calderin, J. D.; Zhou, R.; Pandey, A. M.; Shor, E.; Perlin, D. S.; Wiederhold, N. P.; Ostrosky-Zeichner, L.; Fratti, R. A.; Nacy, C. A.; Oldfield, E.
10.1101/2025.02.03.636131 — microbiology — Posted on 2025-02-03
4727 Sequencing of a dairy isolate unlocks Kluyveromyces marxianus as a host for lactose valorization
Thornbury, M.; Knoops, A.; Summerby-Murray, I.; Dhaliwal, J.; Johnson, S.; Utomo, J.; Joshi, J.; Narcross, L.; Remondetto, G.; Pouliot, M.; Whiteway, M.; Martin, V. J. J.
10.1101/2025.02.03.636257 — synthetic biology — Posted on 2025-02-03
4728 Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha.
Hodgson, K.; Inns, J.; Reynolds, G.; Stephenson, E.; Paul, A.; Sinclair, N.; Berretta, G.; Lawson, C.; Frey, A. M.; Ivanova, I.; Adam, E.; Lord, C. J.; Cockell, S.; Coxhead, J.; Nagy, N.; Adams, D.; Szell, M.; Trost, M.; Haniffa, M.; Mackay, S.; Perkins, N.; Rajan, N.
10.1101/2025.01.31.635629 — cancer biology — Posted on 2025-02-03
4731 Repurposing of the RIPK1 selective benzooxazepin-4-one scaffold for the development of a type-III LIMK1/2 inhibitor
Mandel, S.; Hanke, T.; Mathea, S.; Chatterjee, D.; Saraswati, H.; Berger, B.-T.; Schwalm, M. P.; Yamamoto, S.; Tawada, M.; Takagi, T.; Roehm, S.; Corrionero, A.; Alfonso, P.; Baena, M.; Elson, L.; Tjaden, A.; Kraemer, A.; Pereira, R.; Mueller, S.; Krause, D. S.; Knapp, S.
10.1101/2025.02.03.636296 — biochemistry — Posted on 2025-02-03
4732 Bayesian Inference of Binding Kinetics from Fluorescence Time Series
Bryan, J. S.; Tashev, S. A.; Fazel, M.; Scheckenbach, M.; Tinnefeld, P.; Herten, D.-P.; Presse, S.
10.1101/2025.02.03.636267 — biochemistry — Posted on 2025-02-03
4733 Distinct filament morphology and membrane tethering features of the dual FtsZs in Odinarchaeota
Kumari, J.; Uthaman, A.; Kundu, A.; Dhar, A.; Sharma, V.; Bose, S.; Dutta, S.; Roy, S.; Srinivasan, R.; Pande, S.; Kutti, V. R.; Gayathri, P.; Palani, S.
10.1101/2025.02.03.636245 — biochemistry — Posted on 2025-02-03
4737 Fast Attentional Information Routing via High-Frequency Bursts in the Human Brain
Boroujeni, K. B.; Helfrich, R. F.; Fiebelkorn, I. C.; Bentley, N.; Lin, J. J.; Knight, R. T.; Kastner, S.
10.1101/2024.09.11.612548 — neuroscience — Posted on 2025-02-03
4739 Identifying and treating CLN3 disease outside the central nervous system
Ziolkowska, E. A.; Jablonka, A.; Williams, L. L.; Jansen, M. J.; Wang, S. H.; Eultgen, E. M.; Wood, M. D.; Hunter, D. A.; Sharma, J.; Sardiello, M.; Bradley, R. P.; Whiteman, I. T.; Reese, R.; Pestronk, A.; Sands, M. S.; Heuckeroth, R. O.; Snyder-Warwick, A. K.; Cooper, J. D.
10.1101/2025.01.29.635518 — neuroscience — Posted on 2025-02-03
4742 Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program
Wang, N.; Ockerman, F. P.; Zhou, L. Y.; Grove, M. L.; Alkis, T.; Barnard, J.; Bowler, R. P.; Clish, C. B.; Chung, S.; Drzymalla, E.; Evans, A. M.; Franceschini, N.; Gerszten, R. E.; Gillman, M. G.; Hutton, S. R.; Kelly, R. S.; Kooperberg, C.; Larson, M. G.; Lasky-Su, J. A.; Meyers, D. A.; Woodruff, P. G.; Reiner, A. P.; Rich, S. S.; Rotter, J.; Silverman, E. K.; Ramachandran, V. S.; Weiss, S. T.; Wong, K. E.; Wood, A. C.; Wu, L.; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, ; Yarden, R.; Blackwell, T.; Smith, A. V.; Chen, H.; Raffield, L. M.; Yu, B.
10.1101/2024.07.23.604849 — bioinformatics — Posted on 2025-02-03
4743 GreedyMini: Generating low-density DNA minimizers
Golan, S.; Tziony, I.; Kraus, M.; Orenstein, Y.; Shur, A.
10.1101/2024.10.28.620726 — bioinformatics — Posted on 2025-02-03
4744 Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation
Brinkmeier, M.; Cheung, L. Y. M.; O'Connell, S. P.; Gutierrez, D. K.; Rhoads, E. C.; Camper, S. A.; Davis, S. W.
10.1101/2025.01.30.635771 — developmental biology — Posted on 2025-02-03
4747 Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model
Wakefield, B.; Tang, J.; Balanta Melo, J.; Hutchinson, J. L.; Kanji, R.; Herold, G.; O'Donnell, B. L.; Brooks, C.; Kiser, P.; Grol, M.; Seguin, C. A.; Plotkin, L. I.; Beier, F.; Penuela, S.
10.1101/2023.07.04.547676 — physiology — Posted on 2025-02-03
4750 A chemically defined and xeno-free hydrogel system for regenerative medicine.
Ong, J.; Gibbons, G.; Lim, Y. S.; Zhou, L.; Zhao, J. J.; Justin, A. W.; Cammarata, F.; Rajarethinam, R.; Limegrover, C.; Sinha, S.; Lakatos, A.; Rouhani, F. J.; Dan, Y. Y.; Markaki, A. E.
10.1101/2024.05.28.596179 — bioengineering — Posted on 2025-02-03
4752 TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition
Turpin, M.; Madigou, T.; Bizot, M.; Acker, R.; Avner, S.; Benoit, G.; Braud, M.; Fourgeux, C.; Palierne, G.; Poschmann, J.; Sawvell, K.; Watrin, E.; Le Peron, C.; Salbert, G.
10.1101/2024.04.01.587571 — genomics — Posted on 2025-02-03
4753 Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues
McHugo, G. P.; Ward, J. A.; Browne, J. A.; OGorman, G. M.; Meade, K. G.; Hill, E. W.; Hall, T. J.; MacHugh, D. E.
10.1101/2025.01.31.635858 — genomics — Posted on 2025-02-03
4755 Performance of qpAdm-based screens for genetic admixture on admixture-graph-shaped histories and stepping-stone landscapes
Flegontova, O.; Isıldak, U.; Yüncü, E.; Williams, M. P.; Huber, C. D.; Koci, J.; Vyazov, L. A.; Changmai, P.; Flegontov, P.
10.1101/2023.04.25.538339 — genetics — Posted on 2025-02-03
4756 Multilayer regulation underlies the functional precision and evolvability of the olfactory system
Mermet, J.; Cruchet, S.; Borbora, A. S.; Lee, D.; Chai, P. C.; Jang, A.; Menuz, K.; Benton, R.
10.1101/2025.01.16.632932 — developmental biology — Posted on 2025-02-03
4759 Organoid-based in vitro system and reporter for the study of Cryptosporidium parvum sexual reproduction
Korwin-Mihavics, B. R.; Dews, E. A.; Miller, P. J.; Cameron, A.; Martorelli di Genova, B.; Huston, C. D.
10.1101/2023.09.29.560165 — microbiology — Posted on 2025-02-03
4761 Bait, not reward: CO2-enriched Nepenthes pitchers secrete toxic nectar
Lathika, C. C.; Sujatha, G. B.; Thomas, G.; Johnson, A. J.; Viswanathan, G.; Varghese, T. S.; Mohamed, S.; Shereefa, L. A.; Baby, S.
10.1101/2023.11.25.568661 — plant biology — Posted on 2025-02-03
4762 Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay
Olsen, A.-K.; Ma, X.; Zheng, C.; Dahl, H.; Dirven, Y.; Boisen, A. M.; Sharma, A.; Eide, D. M.; Brunborg, G.
10.1101/2024.12.22.624648 — pharmacology and toxicology — Posted on 2025-02-03
4764 GeNePi: a GPU-enhanced Next Generation Bioinformatics Pipeline for Whole Genome Sequencing Analysis
Marangoni, S.; Furia, F.; Charrance, D.; Fant, A.; Di Dio, S.; Trova, S.; Spirito, G.; Musacchia, F.; Coppe, A.; Gustincich, S.; Cavalli, A.; Vecchi, M.; Landuzzi, F.
10.1101/2025.01.30.635645 — bioinformatics — Posted on 2025-02-03
4768 Brochosomes as an antireflective camouflage coating for leafhoppers
wu, w.; Mao, Q.; Ye, Z.-X.; Liao, Z.; Shan, H.-W.; Li, J.-M.; Zhang, C.-X.; Chen, J.-P.
10.1101/2024.06.13.598800 — ecology — Posted on 2025-02-03
4769 Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1
Laidlaw, K.; Nadir, H.; Milburn, A.; Cruz, M.; Stanislovas, J.; Droop, A.; MacDonald, S.; Andreev, I.; Leech, A.; Ungar, D.; Sadhu, M. J.; MacDonald, C.
10.1101/2024.12.20.629825 — cell biology — Posted on 2025-02-03
4772 SEPSIS-INDUCED LIPID DROPLET ACCUMULATION ENHANCES ANTIBACTERIAL INNATE IMMUNITY
Pereira-Dutra, F. S.; Santos, J. C.; Souza, E. K.; Savi, R. V.; Souza, T. S.; Espinheira-Silva, H.; Moreira, F. F.; Iack, G.; Cunha-Fernandes, T.; Igreja-Silva, T.; Palhinha, L.; Campos, M. M.; Oliveira, D. M.; Soares, V. C.; Rajao, M. A.; Teixeira, L.; Souza-Moreira, L.; Costa, M. F. S.; Reis, P. A.; Bozza, P.
10.1101/2025.01.29.635463 — immunology — Posted on 2025-02-03
4773 Temporal dynamics of viral fitness and the adaptive immune response in HCV infection
Walker, M. R.; Leung, P.; Keoshkerian, E.; Pirozyan, M. R.; Lloyd, A.; Luciani, F.; Bull, R. A.
10.1101/2024.09.07.611784 — immunology — Posted on 2025-02-03
4774 EVIDENCE OF SPATIAL PERIODIC FIRING IN THE SUBICULUM OF MICE
Abad Perez, P.; Scott, R.; Martinez-Otero, L. M.; Borrell, V.; Brotons, J. R.
10.1101/2024.05.10.593498 — neuroscience — Posted on 2025-02-03
4775 Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology
Rodriguez-Rodriguez, P.; Wang, W.; Tsagkogianni, C.; Feng, I.; Morello-Megias, A.; Jain, K.; Alanko, V.; Kahvecioglu, H.; Mohammadi, E.; Li, X.; Flajolet, M.; Sandebring-Matton, A.; Maioli, S.; Vidal, N.; Milosevic, A.; Roussarie, J.-P.
10.1101/2024.12.31.630881 — neuroscience — Posted on 2025-02-03
4777 Altered endothelial mitochondrial Opa1-related fusion in mouse amplifies age-associated vascular and kidney damages
Turnaturi, C.; L'Hoste, L.; Proux, c.; Grimaud, L.; Vessieres, E.; Zorzano, A.; Teissier, A.; Reynier, P.; Sorrentino, R.; Lenaers, G.; Loufrani, L.; Daniel, H.
10.1101/2025.01.29.635602 — physiology — Posted on 2025-02-03
4778 Cardiac diffusion kurtosis imaging in the human heart in vivo using 300mT/m gradients
Afzali, M.; coveney, S.; Mueller, L.; Jones, S.; Fasano, F.; Evans, C. J.; Teh, I.; Dall'Armellina, E.; Szczepankiewicz, F.; Jones, D. K.; Schneider, J. E.
10.1101/2025.01.30.635657 — biophysics — Posted on 2025-02-03
4779 3D dynamic multiscale force and shape analysis of in-vivo elastic stress sensors
Jurado Jimenez, A.; Isensee, J.; Hofemeier, A.; Krueger, L. J.; Wittkowski, R.; Golestanian, R.; Bittihn, P.; Betz, T.
10.1101/2025.01.22.633835 — biophysics — Posted on 2025-02-03
4782 Nora virus proliferates in dividing intestinal stem cells and sensitizes flies to intestinal infection and oxidative stress
Franchet, A.; Haller, S.; Yamba, M.; Barbier, V.; Vieira, A.; Leclerc, V.; Becker, S.; Lee, K.-Z.; Orlov, I.; Spehner, D.; Daeffler, L.; Ferrandon, D.
10.1101/2025.01.30.635658 — immunology — Posted on 2025-02-03
4785 Dysregulation of cell migration by matrix metalloproteinases in geleophysic dysplasia
Morales, A. A.; Camarena, V.; Peart, L.; Smithson, S.; Shaw, L.; Webber, L.; Negron, J. M.; Sola, J. E.; Brady, A.-C.; Walz, K.; Wang, G.; Tekin, M.
10.1101/2025.01.30.635317 — cell biology — Posted on 2025-02-03
4787 Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances
Miwa, S.; Kucheryavenko, O.; Herrmann, K.; Saunter, C.; Raimundo, A.; Weinkove, D.; Niemann, L.; von Zglinicki, T.
10.1101/2025.01.30.635304 — cell biology — Posted on 2025-02-03
4788 Training Generalized Segmentation Networks with Real and Synthetic Cryo-ET data.
Purnell, C.; Heebner, J.; Nguyen, L. T.; Swulius, M. T.; Hylton, R.; Kabonick, S.; Grillo, S.; Grillo, M.; Grigoryev, S.; Heberle, F. A.; Waxham, N.; Swulius, M. T.
10.1101/2025.01.31.635598 — cell biology — Posted on 2025-02-03
4790 On-demand delivery of fibulin-1 enables repeated basement membrane stretching
Soh, A. W. J.; Arnwine, M. R.; Gianakas, C. A.; Clark, Z. D.; Chi, Q.; Cram, E. J.; Hoffman, B. D.; Sherwood, D. R.
10.1101/2025.02.02.636120 — cell biology — Posted on 2025-02-03
4791 FUS post-transcriptional splicing is autoregulated via RNA condensation with therapeutic potential for ALS-FUS
Huang, W.-P.; Kumar, V.; Yap, K.; An, H.; John, S. J.; Hodgson, R. E.; Sanchez Avila, A.; Day, E.; Ellis, B. C. S.; Chung, T. H.; Lord, J.; Müller-McNicoll, M.; Makeyev, E. V.; Shelkovnikova, T. A.
10.1101/2025.02.01.633781 — cell biology — Posted on 2025-02-03
4793 Telomerase mRNA Reduces Radiation-induced DNA Damage of human skin
Chang, D. F.; Li, S.; Court Pinto, K.; Nguyen, T. K. C.; Shah, V. V.; Morales, E.; Carrier, J.; Ludlow, A. T.; Brannan, K. W.; Spiegel, A. J.; Davis, O.; Godin, B.; Mojiri, A.; Cooke, J. P.
10.1101/2025.02.01.636031 — cell biology — Posted on 2025-02-03
4799 HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment
Moschini, G.; Mohanan, A. G.; Niewczas, I. S.; Taylor, D. E.; Jaeger, P. K.; Hussien, A. A.; Wunderli, S. L.; Baumberger, O.; Wolleb, M.; Niederoest, B.; Bollhalder, M.; Ardicoglu, R.; Turiel, G.; Masschelein, E.; Morice, S.; Ardiles, S.; Mous, L.; Aronoff, M. R.; Hilbe, M.; Selman, F.; Wieser, K.; Fucentese, S. F.; Passini, F. S.; Blache, U.; Surdez, D.; Wennemers, H.; Clark, J.; Elewaut, D.; De Bock, K.; Snedeker, J. G.
10.1101/2025.02.02.635939 — cell biology — Posted on 2025-02-03
4800 Mitophagy at the oocyte-to-zygote transition promotes species immortality
Balachandar Thendral, S.; Bacot, S.; Morton, K.; Chi, Q.; Kenny-Ganzert, I. W.; Meyer, J.; Sherwood, D. R.
10.1101/2025.02.01.636045 — cell biology — Posted on 2025-02-03
4801 Targeted Time-Varying Functional Connectivity
Alonso, S.; Cocchi, L.; Hearne, L. J.; Shine, J. M.; Vidaurre, D.
10.1101/2024.08.07.606804 — neuroscience — Posted on 2025-02-03
4803 Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein
Alvarez-Herrera, M.; Ruiz-Rodriguez, P.; Navarro-Dominguez, B.; Zulaica, J.; Grau, B.; Bracho, M. A.; Guerreiro, M.; Aguilar-Gallardo, C.; Gonzalez-Candelas, F.; Comas, I.; Geller, R.; Coscolla, M.
10.1101/2024.01.23.575696 — evolutionary biology — Posted on 2025-02-03
4804 The 3' Region of the ZPA Regulatory Sequence (ZRS) is required for activity and contains a critical E-box
Ball, K. F.; Manu, S.; Underhill, A. K.; Rudd, S. R.; Malone, M. M.; Amoah, J.; Cooper, A. M.; Pira, C. U.; Oberg, K. C.
10.1101/2025.02.01.636055 — developmental biology — Posted on 2025-02-03
4805 An Open-Source Image Analysis Method for Quantifying Reporter Fluorescence
Ball, K. F.; Perez, J. A.; Cooper, A. M.; Pira, C. U.; Oberg, K. C.; Wilson, C. G.
10.1101/2025.02.02.636071 — developmental biology — Posted on 2025-02-03
4808 Post-Ictal Gamma Oscillations Predict Hippocampal Structural Integrity in Mesial Temporal Lobe Epilepsy
Valdivia, D.; Tescarollo, F.; Ercan, K.; Huang, I.; Vasquez, B.; Parsonnet, L. S.; Chung, S.; Boison, D.; Gross, R. E.; Gleichgerrcht, E.; Chen, S. C.-Y.; Sun, H.
10.1101/2025.02.02.636164 — neuroscience — Posted on 2025-02-03
4809 Protein-Like Polymer for Inhibition of Tau Fibril Propagation in Human-Derived Models of Neurodegeneration
Longhini, A. P.; Fattah, M. A.; Sala-Jarque, J.; DuBose, A.; Rivera, E. K.; Sclafani, O. R.; Zhou, J.; Anatot, J. E.; Thompson, M. P.; Unger, M. T.; Beckett, E. R.; Fagan, C.; Nakamura, D.; Morimoto, R.; Han, S.; Qiao, B.; Gianneschi, N. C.; Kosik, K. S.
10.1101/2025.02.02.636155 — neuroscience — Posted on 2025-02-03
4810 The NeflE397K mouse model demonstrates muscle pathology and motor function deficits consistent with CMT2E
Perez-Lopez, D. O.; Shively, A. A.; Torres, F. J. L.; Muchow, R.; Abu-Salah, Z.; Abu-Salah, M. T.; Garcia, M. L.; Smith, C. L.; Nichols, N. L.; Lorson, M. A.; Lorson, C. L.
10.1101/2025.02.02.636119 — neuroscience — Posted on 2025-02-03
4812 Shared Alteration of Whole-Brain Connectivity and Olfactory Deficits in Multiple Autism Mouse Models
Hsu, T.-T.; Chen, C.-P.; Lin, M.-H.; Huang, T.-N.; Wang, C.-Y.; Lee, C.-M.; Chen, B.-C.; Wang, C.-Y.; Hsueh, Y.-P.
10.1101/2025.02.02.636175 — neuroscience — Posted on 2025-02-03
4814 USP7 inhibition perturbs proteostasis and tumorigenesis in triple negative breast cancer
Kim, A.; Gopalakrishnan, P.; Chen, C. C.; Umesh, N.; Mordant, A.; Barker, N. K.; Herring, L. E.; Suarez-Pizarro, M.; Kakati, R. T.; Spanheimer, P. M.; Emanuele, M.; Benavente, C. A.
10.1101/2025.01.28.635372 — cancer biology — Posted on 2025-02-03
4819 A trehalase-derived MAMP triggers LecRK-V-mediated immune responses in Arabidopsis
Iino, E.; Kadota, Y.; Maki, N.; Ono, E.; Sato, K.; Ishihama, N.; Ngou, B. P. M.; Schmid, M. W.; Suzuki, T.; Uehara, T.; Shirasu, K.
10.1101/2025.02.02.636166 — plant biology — Posted on 2025-02-03
4820 Multiple fertility restorer loci for cytoplasmic male sterility caused by orf137 in tomato
Iki, Y.; Harada, I.; Ezura, K.; Mashita, S.; Kuwabara, K.; Takei, H.; Toyoda, A.; Shirasawa, K.; Ariizumi, T.
10.1101/2025.01.31.635880 — plant biology — Posted on 2025-02-03
4821 Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
Salguero-Linares, J.; Armengot, L.; Ayet, J.; Ruiz-Solani, N.; Saile, S.; Salas-Gomez, M.; Fernandez, E.; Denolf, L.; Navarrete, F.; Krumbach, J.; Kaiser, M.; Stael, S.; Van Breusegem, F.; Gevaert, K.; Kaschani, F.; petersen, m.; El Kasmi, F.; Valls, M.; Coll, N. S.
10.1101/2025.01.31.635913 — plant biology — Posted on 2025-02-03
4823 Context-dependent effects of microbial inoculation on sagebrush seedlings during drought stress
Heil, J. A.; Geisler, M.; Skinner, M.; DeFehr, C.; Arogundade, A.; Finney, B.; Bittleston, L. S.
10.1101/2025.01.30.635530 — plant biology — Posted on 2025-02-03
4825 Genetic control of the leaf ionome in pearl millet and correlation with root and agromorphological traits
Nakombo-Gbassault, P.; Arenas, S.; Affortit, P.; Faye, A.; Flis, P.; Sine, B.; Moukouanga, D.; Gantet, P.; Kosh Komba, E.; Kane, N.; Bennett, M.; Wells, D.; Cubry, P.; Bailey, E.; Vigouroux, Y.; Grondin, A.; Laplaze, L.
10.1101/2025.01.30.635630 — plant biology — Posted on 2025-02-03
4829 Activation of alternative oxidase ensures carbon supply for ethylene and carotenoid biosynthesis during tomato fruit ripening
Iglesias-Sanchez, A.; Del-Saz, N. F.; Ezquerro, M.; Feixes-Prats, E.; Ribas-Carbo, M.; Fernie, A. R.; Rodriguez-Concepcion, M.; Florez-Sarasa, I.
10.1101/2025.01.30.635696 — plant biology — Posted on 2025-02-03
4834 Arabidopsis seed stored mRNAs and translation regulation during post-harvest ripening and imbibition.
Balarynova, J.; Klcova, B.; Cegan, R.; Raabe, K.; Krejci, P.; Bednar, P.; Potesil, D.; Pustka, V.; Tarkowska, D.; Tureckova, V.; Zdrahal, Z.; Honys, D.; Smykal, P.
10.1101/2025.01.30.635699 — plant biology — Posted on 2025-02-03
4838 Two cowpea Rubisco activase isoforms for crop thermotolerance
Gjindali, A.; Page, R.; Ashton, C. J.; Robertson, I.; Page, M. T.; Bloemers, D.; Gould, P. D.; Worrall, D.; Orr, D. J.; Carmo-Silva, E.
10.1101/2025.01.31.635870 — plant biology — Posted on 2025-02-03
4840 TransBrain: A computational framework for translating brain-wide phenotypes between humans and mice
Huang, S.; Zhang, T.; Dong, C.; Shi, Y.; Peng, Y.; Liu, X.; Li, K.; Wang, Q.; He, Y.; Xiao, F.; Tian, X.; Xian, J.; Zhang, C.; Wu, Q.; Zou, Y.; Li, L.; Liu, B.; Wang, X.; Li, A.
10.1101/2025.01.27.635016 — neuroscience — Posted on 2025-02-03
4841 The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats
Goldberg, M. E.; Blevins, J. E.; Wolden-Hanson, T.; Elfers, C. T.; Chichura, K. S.; Ashlaw, E. F.; den Hartigh, L. J.; Roth, C. L.; Doyle, R. P.
10.1101/2025.01.06.631534 — physiology — Posted on 2025-02-03
4843 I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation
Fu, Z.; Geisbrecht, B. V.; Bouyain, S.; Dyda, F.; Chrzas, J. J.; Kandavelu, P.; Miller, D. J.; Wang, B.-C.
10.1101/2024.12.10.627855 — biophysics — Posted on 2025-02-02
4845 Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components
Kshirsagar, A.; Mnatsakanyan, H.; Kulkarni, S.; Guo, J.; Cheng, K.; Bohra, O.; Sagar, R.; MACHAIRAKI, V.; Badr, C. E.; Kathuria, A.
10.1101/2025.01.20.633788 — bioengineering — Posted on 2025-02-02
4846 Polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome cellular models
Sola, A.; Sandberg, A.; Pham, C.; Revier, A.; Hebinck, M.; Penney, A.; Caviedes, P.; Kumar, S.; Granholm, A.-C.; Linseman, D.; Paredes, D.
10.1101/2025.01.31.635912 — biochemistry — Posted on 2025-02-03
4847 Sparse Sequencing permits accurate and efficient quantification of genome-wide cytosine modification levels
Loo, C. E.; Fowler, J. M.; Zhu, H.; Krapp, C.; Zhu, R.; Bartolomei, M.; Zhou, W.; Kohli, R. M.
10.1101/2025.01.08.631958 — genomics — Posted on 2025-02-03
4848 Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling animal evolution and adaptation
Page-McCaw, P. S.; Pokidysheva, E. N.; Darris, C. E.; Chetyrkin, S.; Fidler, A. L.; Gallup, J.; Aspirnauts, ; Murawala, P.; Hudson, J. K.; Boudko, S.; Hudson, B. G.
10.1101/2023.10.18.563013 — evolutionary biology — Posted on 2025-02-03
4849 Prenatal adversity configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety
Nabila, A.; Sciortino, R.; Politowska, N.; Brindley, E.; Hamor, P. U.; Zallar, L.; Toth, J. G.; Pleil, K.; Toth, M.
10.1101/2025.02.02.636173 — neuroscience — Posted on 2025-02-02
4851 Gut-Brain Hydraulics: Brain motion and CSF circulation is driven by mechanical coupling with the abdomen
Garborg, C. S.; Ghitti, B.; Zhang, Q.; Ricotta, J.; Frank, N.; Mueller, S.; Greenawalt, D.; Turner, K.; Kedarasetti, R.; Mostafa, M.; Lee, H.; Costanzo, F.; Drew, P. J.
10.1101/2025.01.30.635779 — neuroscience — Posted on 2025-02-03
4856 The beta-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake
Stavrou-Dowd, Z. T.; Parsons, G.; Rose, C.; Brown, F.; Lees, R. S.; Acosta-Serrano, A.; Haines, L. R.
10.1101/2025.01.29.635148 — zoology — Posted on 2025-02-02
4858 Lytic IFNγ is stored in granzyme B-containing cytotoxic granules and co-secreted by effector CD8⁺ T cells
Li, X.; Schirra, C.; Tu, S.-M.; Wirkner, M.-L.; Lin, C.-H.; Hohmann, M.; Alawar, N.; Chouaib, A.; Becherer, U.; Pattu, V.; Rettig, J.; Krause, E.; Chang, H.-F.
10.1101/2025.01.29.635520 — immunology — Posted on 2025-02-02
4859 A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo
Zhou, S.; Zhu, Q.; Eom, M.; Fang, S.; Subach, O. M.; Ran, C.; Singh, J. A.; Sunkavalli, P. S.; Dong, Y.; Wang, Y.; Hu, J.; Zhang, H.; Wang, Z.; Sun, X.; Yang, T.; Mu, Y.; Yoon, Y.-G.; Guo, Z. V.; Subach, F. V.; Piatkevich, K. D.
10.1101/2025.01.31.635851 — neuroscience — Posted on 2025-02-02
4861 Dietary Menaquinone-9 Supplementation Does Not Influence Bone Tissue Quality or Bone Mineral Density in Mice
Liu, M.; Liu, C.; Cevallos, N.; Orbach, B.; Hernandez, C. J.; Fu, X.; Lee, J.; Booth, S.; Shea, K.
10.1101/2025.01.29.635567 — physiology — Posted on 2025-02-02
4862 Microbial metabolite 4-ethylphenylsulfate (4EPS) interacts with AT1R, reduces blood pressure and outcome of AngII-induced aortic aneurysm
Harford, T.; Singh, K. D.; Pardhi, T. R.; Desnoyer, R.; Ravi, T.; Jara, Z. P.; Zalavadia, A.; Stenson, K.; Prasad, S. N. N.; Karnik, S. S.
10.1101/2025.01.29.635371 — pathology — Posted on 2025-02-02
4865 Somatostatin Receptor 2 Overexpression in Hepatocellular Carcinoma: Implications for Cancer Biology and Theranostic Applications
Momeny, M.; Vargas, S. H.; AghaAmiri, S.; Adams, J. T.; Bateman, T. M.; Ghosh, S. C.; Acidi, B.; Kaseb, A. O.; Cao, H. S. T.; Azhdarinia, A.
10.1101/2025.01.29.635283 — cancer biology — Posted on 2025-02-02
4867 Chronic Antigen Stimulation in Solid Tumors Induces T Cell Exhaustion and Limits Efficacy of T Cell Bispecific Therapies
Hutter-Karakoc, I.; Varypataki, E. M.; Neelakandhan, A.; Lang, S.; Kramar, V.; Varol, A.; Simons, S.; Richard, M.; Pincha, M.; Venetz, D.; Joller, N.; Muenz, C.; Umana, P.; Klein, C.; Amann, M.
10.1101/2025.01.29.635556 — cancer biology — Posted on 2025-02-02
4869 CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma
McAndrews, K. M.; Mahadevan, K. K.; Li, B.; Sockwell, A. M.; Morse, S. J.; Kelly, P. J.; Patel, S. I.; Kirtley, M. L.; Diaz, B. A. M.; Lyu, H.; Zhou, X.; Sugimoto, H.; Sthanam, L. K.; Conner, M. R.; Kumbhar, S. V.; Arian, K. A.; Barekatain, Y.; Paradiso, F.; Guerrero, P. A.; Bernard, V.; Sobhani, N.; Camacho-Acevedo, A. N.; Bornes, K. E.; Tran, P. T.; Maitra, A.; Heffernan, T. P.; Kalluri, R.
10.1101/2025.01.29.635543 — cancer biology — Posted on 2025-02-02
4871 MassVision: An Open-Source End-to-End Platform for AI-Driven Mass Spectrometry Image Analysis
Jamzad, A.; Warren, J.; Syeda, A.; Kaufmann, M.; Iaboni, N.; Nicol, C.; Rudan, J.; Ren, K.; Hurlbut, D.; Varma, S.; Fichtinger, G.; Mousavi, P.
10.1101/2025.01.29.635489 — bioinformatics — Posted on 2025-02-02
4880 Utilizing Genomics to Identify Novel Immunotherapeutic Targets in Multiple Myeloma High-Risk Subgroups
liu, e.; Jaouadi, O.; Sharma, R.; Becker, N.; Johnson, T.; Sudha, P.; Chopra, V.; Zafar, F.; Hamidi, H.; Pawlyn, C.; Suvannasankha, A.; Abonour, R.; Walker, B. A.
10.1101/2025.01.29.635544 — genomics — Posted on 2025-02-02
4882 Platform-dependent effects of genetic variants on plasma APOL1 and their implications for kidney disease
Wang, Q. S.; Huang, J.; Chan, L.; Haste, N.; Olsson, N.; Gaun, A.; McAllister, F.; Madhireddy, D.; Baruch, A.; Melamud, E.; Baryshnikova, A.
10.1101/2025.01.30.635763 — genetics — Posted on 2025-02-02
4884 Concordant yet unique neutral and adaptive genomic responses to anthropogenically modified landscapes in Rhinella horribilis
Soria-Ortiz, G. J.; Ochoa-Ochoa, L. M.; Jaramillo-Correa, J. P.; Martinez-Solano, I.; Vazquez-Dominguez, E.
10.1101/2025.01.29.635472 — evolutionary biology — Posted on 2025-02-02
4893 ROR2 drives right ventricular heart failure via disruption of proteostasis
Hartman, H.; Uy, G.; Uchida, K.; Scarborough, E. A.; Yang, Y.; Barr, E.; Williams, S.; Kavari, S.; Brandimarto, J.; Li, L.; Lai, L.; Griffin, J.; Yucel, N.; Shewale, S.; Rajagopal, H.; Eaton, D. M.; Dorwart, T.; Bedi, K. C.; Conn, C. S.; Margulies, K.; Prosser, B.; Arany, Z.; Edwards, J. J.
10.1101/2025.02.01.635961 — molecular biology — Posted on 2025-02-02
4895 Quorum sensing regulation by the nitrogen phosphotransferase system in Pseudomonas aeruginosa
Banerjee, S.; Smalley, N. E.; Saenjamsai, P.; Fehr, A.; Dandekar, A. A.; Cabeen, M. T.; Chandler, J. R.
10.1101/2025.02.01.636002 — microbiology — Posted on 2025-02-02
4897 Mosquito host background influences microbiome-ZIKV interactions in field and laboratory-reared Aedes aegypti
Cansado-Utrilla, C.; Saldana, M. A.; Golovko, G.; Khanipov, K.; Wild, A. L.; Brettell, L. E.; Weaver, S. C.; Heinz, E.; Hughes, G. L.
10.1101/2025.02.02.636091 — microbiology — Posted on 2025-02-02
4898 Horizontal gene transfer of the functional archaellum machinery to Bacteria
Sivabalasarma, S.; Taib, N.; Mollat, C. L.; Joest, M.; Steimle, S.; Gribaldo, S.; Albers, S.-V.
10.1101/2025.02.02.636118 — microbiology — Posted on 2025-02-02
4899 Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8+ T cells in triple-negative breast cancer
Lim, B. J. W.; Liu, M.; Wang, L.; Kong, S. L. Y.; Yin, T.; Yan, C.; Xiang, K.; Cao, C.; Wu, H.; Mihai, A.; Tay, F.; Wang, E.; Jiang, Q.; Ma, Z.; Tan, L.; Chia, R. N.; Qin, D.; Pan, C. C.; Wang, X.-F.; Li, Q.-J.
10.1101/2025.01.29.635356 — immunology — Posted on 2025-02-02
4900 Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome
Turcotte, E. A.; Kim, K.; Eislmayr, K. D.; Goers, L.; Mitchell, P. S.; Lesser, C. F.; Vance, R. E.
10.1101/2025.02.01.636075 — immunology — Posted on 2025-02-02
4901 Dose Escalation in Pentylenetetrazol Kindling Detects Differences in Chronic Seizure Susceptibility
Moyer, M. B.; Langbein, J.; Tsymbalyuk, O.; McAfee, D.; Chen, C.; Bachani, M.; Gerzanich, V.; Simard, J. M.; Ksendzovsky, A.
10.1101/2025.01.29.635374 — neuroscience — Posted on 2025-02-02
4903 A maize near-isogenic line population designed for gene discovery and characterization of allelic effects
Zhong, T.; Mullens, A.; Morales, L.; Swarts, K.; Stafstrom, W.; He, Y.; Sermons, S.; Yang, Q.; Lopez-Zuniga, L. O.; Rucker, E.; Thomason, W.; Nelson, R.; Jamann, T. M.; Balint-Kurti, P.; Holland, J. B.
10.1101/2025.01.29.635337 — plant biology — Posted on 2025-02-02
4904 Chronic Inhaled Benzene Exposure Exacerbates Atherosclerosis in LDL Receptor-Knockout Mice
Zelko, I. N.; Malovichko, M. V.; McFall, S. A.; Taylor, B. S.; Chen, H.; Conklin, D. J.; Srivastava, S.
10.1101/2025.01.29.635519 — pharmacology and toxicology — Posted on 2025-02-02
4907 A Robust Fluorogenic Substrate for Chikungunya Virus Protease (nsP2) Activity
Makhaik, S.; Rut, W.; Choudhary, S.; Upadhyay, T.; Hao, C.; Westberg, M.; Bobst, C.; Yoo, E.; Fejzo, J.; Lin, M.; Bogyo, M.; Thompson, P.; Drag, M.; Hardy, J. A.
10.1101/2025.02.01.636040 — biochemistry — Posted on 2025-02-02
4909 Bacterial IF2's N-terminal IDR drives cold-induced phase separation and promotes fitness during cold stress
Ghosh, A.; Mallikarachchi, K. S.; Dzurik, K. G.; Nandana, V.; Nunez, N. R.; Childers, W. S.; Schrader, J. M.
10.1101/2025.02.02.631968 — microbiology — Posted on 2025-02-02
4910 The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue
Rowland, L. A.; Santos, K. B.; Guilherme, A.; Munroe, S.; Lifshitz, L. M.; Nicoloro, S.; Wang, H.; Yee, M. F.; Czech, M. P.
10.1101/2025.02.02.636110 — molecular biology — Posted on 2025-02-02
4911 Dietary macronutrients modulate the proteome of brown adipose tissue in males and their female offspring
Macartney, E. L.; Senior, A.; Crean, A. J.; Small, L.; Pulpitel, T.; Nobrega, M. A.; Barres, R.
10.1101/2025.02.01.636065 — molecular biology — Posted on 2025-02-02
4913 Characterization of the Cellular Immune Response to Group B Streptococcal Vaginal Colonization
Spencer, B. L.; Nguyen, D. T.; Marroquin, S. M.; Gapin, L.; O'Brien, R. L.; Doran, K. S.
10.1101/2025.01.29.635275 — immunology — Posted on 2025-02-02
4917 Interparticle Crosslinked Ion-responsive Microgels for 3D and 4D (Bio)printing Applications
Pal, V.; Gupta, D.; Liu, S.; Namli, I.; Rizvi, S. H. A.; Yilmaz, Y. O.; Haugh, L.; Gerhard, E. M.; Ozbolat, I. T.
10.1101/2025.01.28.635095 — bioengineering — Posted on 2025-02-02
4918 DyAb: sequence-based antibody design and property prediction in a low-data regime
Lin, J. Y.-Y.; Hofmann, J. L.; Leaver-Fay, A.; Liang, W.-C.; Vasilaki, S.; Lee, E.; Pinheiro, P. O.; Tagasovska, N.; Kiefer, J. R.; Wu, Y.; Seeger, F.; Bonneau, R.; Gligorijevic, V.; Watkins, A.; Cho, K.; Frey, N. C.
10.1101/2025.01.28.635353 — bioengineering — Posted on 2025-02-02
4920 Divergent ecological selection causes partial reproductive isolation and vast genomic instability in yeast
Bendixsen, D. P.; Gilchrist, C.; Haberkorn, C.; Persson, K.; Geijer, C.; Warringer, J.; Stelkens, R.
10.1101/2025.01.28.635359 — evolutionary biology — Posted on 2025-02-02
4923 Engineering mice for female-biased progeny without impacting genetic integrity and litter size
Yosef, I.; Mahata, T.; Xie, X.; Chen, Y.; Bar-Joseph, H.; Sun, Q.-Y.; Shalgi, R.; Munitz, A.; Gerlic, M.; Qimron, U.
10.1101/2023.11.21.568055 — bioengineering — Posted on 2025-02-02
4926 CoSMIC - A hybrid approach for large-scale, high-resolution microbial profiling of novel niches
Knafo, M.; Rezenman, S.; Idan, T.; Elgart, M.; Dagan, S.; Reich, Z.; Kapon, R.; Sade, D.; Shental, N.
10.1101/2023.09.03.556087 — molecular biology — Posted on 2025-02-02
4930 Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training
Hulmi, J. J.; Halonen, E. J.; Sharples, A. P.; O'Connell, T. M.; Kuikka, L.; Lappi, V.-M.; Salokas, K.; Keskitalo, S.; Varjosalo, M.; Ahtiainen, J. P.
10.1101/2024.11.19.624068 — physiology — Posted on 2025-02-02
4931 Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancer
Cao, P.; Zhou, X.; Yang, S.; Shen, T.; Wang, S.; Yu, H.; Liu, X.; Gong, Y.; Wang, W.; Wang, H.; Zhou, T.; Wang, J.; Fan, Z.; Huang, M.; Qian, X.; Wang, X.; Wang, Q.; Yang, L.; Zhang, Y.; Lin, F.
10.1101/2024.11.15.623304 — cancer biology — Posted on 2025-02-02
4932 Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.
Vareli, A.; Narayanan, H. V.; Clark, H.; Jayawant, E.; Zhou, H.; Liu, Y.; Stott, L.; Simoes, F.; Hoffmann, A.; Pepper, A.; Pepper, C.; Mitchell, S.
10.1101/2024.11.30.626166 — cancer biology — Posted on 2025-02-02
4933 Evaluation of sequencing reads at scale using rdeval
Formenti, G.; Koo, B.; Sollitto, M.; Balacco, J.; Brajuka, N.; Burhans, R.; Duarte, E.; Giani, A. M.; McCaffrey, K.; Medico, J. A.; Myers, E. W.; Jarvis, E. D.
10.1101/2025.02.01.636073 — bioinformatics — Posted on 2025-02-01
4934 GreedyMini: Generating low-density DNA minimizers
Golan, S.; Tziony, I.; Kraus, M.; Orenstein, Y.; Shur, A.
10.1101/2024.10.28.620726 — bioinformatics — Posted on 2025-02-02
4935 AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production
Kang, L.; Wu, B.; Zhou, B.; Tan, P.; Kang, Y.; Yan, Y.; Zong, Y.; Li, S.; Liu, Z.; Hong, L.
10.1101/2024.09.04.611192 — bioengineering — Posted on 2025-02-01
4936 Dark side of the honeymoon: reconstructing the Asian x European rose breeding history through the lens of genomics
Leroy, T.; Albert, E.; Thouroude, T.; Baudino, S.; Caissard, J.-C.; Chastellier, A.; Chameau, J.; Jeauffre, J.; Loubert, T.; Paramita, S. N.; Pernet, A.; Soufflet-Freslon, V.; Oghina-Pavie, C.; Foucher, F.; Oyant, L. H.-S.; Clotault, J.
10.1101/2023.06.22.546162 — genomics — Posted on 2025-02-01
4937 Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2
Kobayashi, H.; Igaki, T.; Kumamoto, S.; Tanaka, K.; Takashima, T.; Nagaoka, S. I.; Suzuki, S.; Hayashi, M.; Renfree, M. B.; Kawahara, M.; Saito, S.; Kobayashi, T.; Nagashima, H.; Nakano, K.; Matsunari, H.; Uchikura, A.; Kiyonari, H.; Kaneko, M.; Imai, H.; Nakabayashi, K.; Lorincz, M. C.; Kurimoto, K.
10.1101/2023.10.30.564869 — genomics — Posted on 2025-02-02
4942 Trans-synaptic molecular context of NMDA receptor nanodomains
Anderson, M. C.; Dharmasri, P. A.; Damenti, M.; Metzbower, S. R.; Laghaei, R.; Blanpied, T. A.; Levy, A. D.
10.1101/2023.12.22.573055 — neuroscience — Posted on 2025-02-01
4943 Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation
Wang, J.; Nishiyama, J.; Parra-Bueno, P.; Okaz, E.; Oz, G.; Liu, X.; Watabe, T.; Suponitsky-Kroyter, I.; McGraw, T. E.; Szatmari, E. M.; Yasuda, R.
10.1101/2022.05.17.492345 — neuroscience — Posted on 2025-02-01
4945 The coarse mental map of the breast is anchored on the nipple
Long, K.; Fitzgerald, E.; Berger-Wolf, E.; Fawaz, A.; Lindau, S.; Bensmaia, S. J.; Greenspon, C.
10.1101/2022.09.14.507974 — neuroscience — Posted on 2025-02-02
4946 Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimers Disease
de Paiva Lopes, K.; A. Vialle, R.; Green, G.; Fujita, M.; Gaiteri, C.; Menon, V.; Schneider, J. A.; Wang, Y.; De Jager, P.; Habib, N.; Tasaki, S.; Bennett, D. A.
10.1101/2025.01.31.635970 — systems biology — Posted on 2025-02-01
4947 Progesterone regulation of cervix ripening in preterm and term birth
Yellon, S.; Ward, D.; Thompson, A.; Vazquez, B.; Baldwin, D. D.; Oldford, E. J.; Kirby, M.
10.1101/2025.01.31.636012 — physiology — Posted on 2025-02-01
4950 Investigation of immune response to Mesenchymal Stromal Cell-derived Extracellular Vesicles in the cancer setting
Gilligan, K. E.; Treacy, O.; O'Neill, C. O.; McCarthy, E. C.; McDermott, E.; Mammen, E.; Dockery, P.; Ryan, A. E.; Dwyer, R. M.
10.1101/2025.01.28.635343 — cancer biology — Posted on 2025-02-01
4951 Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications
Feofanov, M.; Daubner, G. M.; Saltalamacchi, A.; Koehner, K.; Schulz, C.; Henry, C. E.; Ziegler, M. J.; Benabderrahmane, M.; Hiault, F. A. S.; Decker, T.-M.; Shen, M.-C.; Pahl, J.; Lambertz, S. K.; Noori, H. R.
10.1101/2025.01.30.635029 — biochemistry — Posted on 2025-02-01
4954 Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2
Makrides, N.; Sun, E.; Mir, H.; Jiang, Z.; Wu, Y.; Serra, C. F. H. S.; Cardoso, W. V.; Shah, N. H.; Zhang, X.
10.1101/2025.01.28.635289 — pathology — Posted on 2025-02-01
4955 Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype
Hoppe, S.; Noseir, S.; Yazbeck, A.; Zaburannyi, N.; Grossbach, J.; Lyu, S. I.; Camacho, O. V.; Mueller, S.; Gebauer, F.; Richartz, V.; Holz, B.; Berg, J.; Achter, V.; Altmueller, J.; Becker, K.; Arolt, C.; Meder, L.; Zhao, Y.; Schloesser, H.; Baus, W. W.; Kamp, F.; Baues, C.; Beyer, A.; Odenthal, M.; Quaas, A.; Buettner, R.; Hillmer, A. M.
10.1101/2025.01.28.635332 — cancer biology — Posted on 2025-02-01
4956 Overcoming Immune Checkpoint Inhibitor Resistance via Potent and Selective Dual αvβ6/8 Inhibitors Based on Engineered Lasso Peptides
Lechner, A.; Jordan, P. A.; da Cruz, G. C. M.; Lamson, J.; Gordon, J.; Okada, B. K.; Anderson, K.; Chaudhari, R.; Rosario, C. J.; Mikesell, J.; McPhee, S. A.; Burk, M. J.
10.1101/2025.01.28.635346 — cancer biology — Posted on 2025-02-01
4957 ECD co-operates with ERBB2 to promote tumorigenesis through upregulation of unfolded protein response and glycolysis
Kennedy, B. B.; Raza, M.; Mirza, S.; Rajan, A. R.; Oruji, F.; Storck, M. M.; Lele, S. M.; Reznicek, T. E.; Li, L.; Rowley, M. J.; Wan, S.; Mohapatra, B. C.; Band, H.; Band, V.
10.1101/2025.01.28.635284 — cancer biology — Posted on 2025-02-01
4958 SCGclust: Single Cell Graph clustering using graphautoencoders integrating SNVs and CNAs
Potu, T.; Hu, Y.; Khan, R.; Dharani, S.; Ni, J.; Zhang, L.; Zhou, X. M.; Mallory, X.
10.1101/2025.01.28.635357 — bioinformatics — Posted on 2025-02-01
4959 Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation
Elshazly, A. M.; Hosseini, N.; Shen, S.; Neely, V.; Harada, H.; Grant, S.; Radhakrishnan, S. K.
10.1101/2025.01.31.634950 — biochemistry — Posted on 2025-02-01
4960 Improving American chestnut resistance to two invasive pathogens through genome-enabled breeding
Westbrook, J. W.; Malukiewicz, J.; Sreedasyam, A.; Jenkins, J. W.; Zhang, Q.; Lakoba, V.; Fitzsimmons, S. F.; Van Clief, J.; Collins, K.; Hoy, S.; Stark, C.; Grabowski, L.; Jenkins, E.; Saielli, T.; Jarrett, B. T.; Wigfield, L.; Kerwien, L. M.; Wilbur, C.; Sandercock, A.; Craddock, J. H.; Zannini, P.; Kerio, S.; Zhebentyayeva, T.; Fan, S.; Thomas, A.; Abbott, A.; Nelson, C. D.; Xia, X.; Williams, M.; Boston, L.; Plott, C.; Carle, F.; Swatt, J.; Ostroff, J.; Jeffers, S.; Mckeever, K.; Smith, E.; Ellis, T. J.; James, J. B.; Sisco, P.; Newhouse, A. E.; Carlson, E.; Powell, W. A.; Hebard, F. V.; S
10.1101/2025.01.30.635736 — genomics — Posted on 2025-02-01
4962 Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene
Kothe, J. A. F.; Sauerwein, T.; Dietz, T.; Scheuer, R.; Elhossary, M. M.; Barth-Weber, S.; Waehling, J.; Foerstner, K. U.; Evguenieva-Hackenberg, E.
10.1101/2025.01.31.635925 — molecular biology — Posted on 2025-02-01
4964 The yeast phosphofructokinase β-subunit has ATP-dependent RNA unwinding activity and modulates cell cycle progression
Albihlal, W.; Matia-Gonzalez, A. M.; Schmidt, T.; Mayer, W.; Bushell, M.; Niessing, D.; Barberis, M.; Schmidt, A.; Heinisch, J. J.; Gerber, A. P.
10.1101/2025.02.01.636022 — molecular biology — Posted on 2025-02-01
4968 Discovery of a distinct BAM complex in the Bacteroidetes
Silale, A.; Madej, M.; Mikruta, K.; Frey, A. M.; Hart, A. J.; Basle, A.; Scavenius, C.; Enghild, J. J.; Trost, M.; Hirt, R. P.; van den Berg, B.
10.1101/2025.01.31.636011 — microbiology — Posted on 2025-02-01
4970 B cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells
Morelli, D. M.; Langille, M.; Zhang, R.; Craig, H. C.; Shooshtari, P.; Heit, B.; Kerfoot, S. M.
10.1101/2025.01.28.635276 — immunology — Posted on 2025-02-01
4971 Dicer loss in Muller glia leads to a defined sequence of pathological events beginning with cone dysfunction
Larbi, D.; Rief, A. M.; Kang, S.; Chen, S.; Batsuuri, K.; Fuhrmann, S.; Viswanathan, S.; Wohl, S. G.
10.1101/2025.01.30.635744 — neuroscience — Posted on 2025-02-01
4973 BlueBerry: Closed-loop wireless optogenetic manipulation in freely moving animals
Nourizonoz, A.; Girard, B.; Guyoton, M.; Galinanes, G.; Thurnherr, R.; Pellat, S.; Bellone, C.; Huber, D.
10.1101/2025.01.30.635697 — neuroscience — Posted on 2025-02-01
4977 Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma.
Radke, K.; Aaltonen, K.; Mucino-Olmos, E. A.; Esfandyari, J.; Manas, A.; Seger, A.; Adamska, A.; Hansson, K.; Rogova, O.; Mason, D. J.; O'Donovan, D. J.; Roberts, I.; Lock, A.; Brennan, J.; Davies, E. J.; Spegel, P.; Bedoya-Reina, O. C.; Brown, D.; Thompson, N. T.; Spadoni, C.; Bexell, D.
10.1101/2025.01.28.635193 — cancer biology — Posted on 2025-02-01
4978 In vivo targeted gene delivery using Adenovirus-antibody molecular glue conjugates
Rice-Boucher, P. J.; Kashentseva, E. A.; Dmitriev, I. P.; Guo, H.; Tremblay, J. M.; Shoemaker, C. B.; Curiel, D. T.; Lu, Z. H.
10.1101/2025.01.31.635969 — bioengineering — Posted on 2025-02-01
4979 Polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome cellular models
Paredes, D.; Sola, A.; Sandberg, A.; Pham, C.; Revier, A.; Hebinck, M.; Penney, A.; Caviedes, P.; Kumar, S.; Granholm, A.-C.; Linseman, D.
10.1101/2025.01.31.635912 — biochemistry — Posted on 2025-02-01
4981 Metabolic reprogramming in the spinal cord drives the transition to pain chronicity
Tagne, A. M.; Fotio, Y.; Lee, H.-L.; Jung, K.-M.; Katz, J.; Ahmed, F.; Le, J.; Bazinet, R.; Jang, C.; Piomelli, D.
10.1101/2025.01.30.635746 — neuroscience — Posted on 2025-02-01
4982 A Human Neuron Alzheimer's Disease Model Reveals Barriers to Senolytic Translatability
Walton, C. C.; Wang, E.; Lee, S.; Siebrand, C. J.; Bergo, N. J.; Andersen, J. K.
10.1101/2025.01.28.635165 — neuroscience — Posted on 2025-02-01
4983 Gut-Brain Hydraulics: Brain motion and CSF circulation is driven by mechanical coupling with the abdomen
Garborg, C. S.; Ghitti, B.; Zhang, Q.; Riccotta, J.; Frank, N.; Mueller, S.; Greenawalt, D.; Turner, K.; Kedarasetti, R.; Mostafa, M.; Lee, H.; Costanzo, F.; Drew, P. J.
10.1101/2025.01.30.635779 — neuroscience — Posted on 2025-02-01
4984 FETCH enables fluorescent labeling of membrane proteins in vivo with spatiotemporal control in Drosophila
Rostam, K. D.; Morano, N. C.; Menon, K. P.; Lopez, D. H.; Shapiro, L.; Zinn, K.; Feng, S.; Mann, R. S.
10.1101/2025.01.31.635819 — neuroscience — Posted on 2025-02-01
4986 Early neural responses to nonconscious fearful and neutral faces - an ERP study
Bruchmann, M.; Schindler, S.; Breitwieser, P.; Tilly, L.; Boelte, J.; Dellert, T.; Straube, T.
10.1101/2025.01.30.635452 — neuroscience — Posted on 2025-02-01
4987 Regulation of early-stage tomato fruit growth by the splicing factor RS2Z36
Vraggalas, S.; Rosenkranz, R. R.; Keller, M.; Perez-Perez, Y.; Bachiri, S.; Zehl, K.; Bold, J.; Simm, S.; Ghatak, A.; Weckwerth, W.; Afjehi-Sadat, L.; Chaturvedi, P.; Testillano, P. S.; Mueller-McNicoll, M.; Zarnack, K.; Fragkostefanakis, S.
10.1101/2025.01.31.635986 — developmental biology — Posted on 2025-02-01
4989 Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling
Ramelow, C. C.; Dammer, E. B.; Xiao, H.; Cheng, L.; Kumar, P.; Espinosa-Garcia, C.; Sampson, M. M.; Nelson, R. S.; Malepati, S.; Kour, D.; Kumari, R.; Guo, Q.; Bagchi, P.; Duong, D. M.; Seyfried, N. T.; Sloan, S. A.; Rangaraju, S.
10.1101/2025.01.29.635500 — neuroscience — Posted on 2025-02-01
4990 A brainstem-thalamic circuitry for affective-motivational responses to cold pain
Reddy, P.; Okuda, T.; Rani, M.; Prajapati, J. N.; Samineni, V. K.; Koul, S.; Barik, A.
10.1101/2025.01.31.636010 — neuroscience — Posted on 2025-02-01
4993 TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy
Levi-DAncona, E.; Walker, E. M.; Zhu, J.; Deng, Y.; Sidarala, V.; Stendahl, A. M.; Reck, E. C.; Henry-Kanarek, B. A.; Lietzke, A. C.; Pasmooij, M. B.; Hubers, D. L.; Basrur, V.; Ghosh, S.; Stiles, L.; Nesvizhskii, A. I.; Shirihai, O. S.; Soleimanpour, S. A.
10.1101/2025.01.31.635900 — molecular biology — Posted on 2025-02-01
4996 Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance
Nattel, S.; Qi, X.; Xiong, F.; Xiao, J.; Muthukumarasamy, K. M.; Altuntas, Y.; Zhong, Y.; Abu-Taha, I.; Bruns, F.; Tekook, M.; Kamler, M.; Villeneuve, L.; Nozza, A.; Sirois, M.; Karch, J.; Pasdois, P.; Bers, D. M.; Dobrev, D.
10.1101/2025.01.29.635508 — pathology — Posted on 2025-02-01
4998 The NIH BRAIN Initiatives Impacts in Systems and Computational Neuroscience, 2014-2023
Bader, F.; Bingham, C.; David, K. K.; Gebrehiwet, H.; Lantz, C.; Peng, G. C. Y.; Rangel-Gomez, M.; Gnadt, J.
10.1101/2025.01.30.635684 — neuroscience — Posted on 2025-02-01
4999 Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis
Tanca, A.; Schallert, K.; Grenga, L.; Peters, S. L.; Abbondio, M.; De Diego, L.; Deledda, M. A.; Haange, S.-B.; Miotello, G.; Saenz, J. S.; Wolf, M.; Devos, S.; Hernandez-Raquet, G.; Seifert, J.; Wilmes, P.; Van Den Bossche, T.; Kunath, B. J.; Heyer, R.; Jehmlich, N.; Benndorf, D.; Hettich, R. L.; Armengaud, J.; Uzzau, S.
10.1101/2025.01.31.635836 — microbiology — Posted on 2025-02-01
5002 Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion.
Zhu, Y.; LI, A.; Maji, S.; Lee, B. J.; Korn, S. M.; Gertie, J. A.; Dorrity, T. J.; Wang, J.; Wang, K. J.; Pelletier, A.; Moakley, D. F.; Kelly, R. D.; Holmes, A. B.; Rabadan, R.; Edgell, D. R.; Schild-Poulter, C.; Modesti, M.; Steckelberg, A.-L.; Hendrickson, E. A.; Chung, H.; Zhang, C.; Zha, S.
10.1101/2025.01.31.633084 — genetics — Posted on 2025-02-01
5003 Conditional Dystrophin ablation causes profound effects on muscle development, neurobehavior, and extracellular matrix pathways
Karuppasamy, M.; English, K. G.; Conner, J. R.; Lopez, M. A.; Crossman, D. K.; Paul, J. R.; Monreal-Gutierrez, M. A.; Gamble, K. L.; Esser, K. A.; Widrick, J. J.; Kunkel, L. M.; Alexander, M. S.
10.1101/2025.01.30.635777 — genetics — Posted on 2025-02-01
5004 Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice
Sloan, K.; Piner, K. M.; Arachchige, P. R. N. K.; Goodlett, C. R.; Herault, Y.; Olbricht, G. R.; Wallace, J. M.; Roper, R. J.
10.1101/2025.01.31.635850 — genetics — Posted on 2025-02-01
5006 A Multivalent Pan-Ebolavirus Nanoparticle Vaccine Provides Protection in Rodents from Lethal Infection by Adapted Zaire and Sudan Viruses
Brunette, N.; Weidle, C.; Wrenn, S. P.; Fiala, B.; Ravichandran, R.; Carr, K. D.; Zak, S. E.; Zumbrun, E. E.; Bakken, R. R.; Murphy, M.; Chan, S.; Skotheim, R.; Borst, A. J.; Carter, L.; Correnti, C. E.; Dye, J. M.; Baker, D.; King, N. P.; Stewart, L. J.
10.1101/2025.01.29.635581 — immunology — Posted on 2025-02-01
5008 AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon
Hold, L. A.; Migotsky, N.; Chen, J.; Steltzer, S. S.; Cordts, P.; Bae, S.-H.; Grossman, S.; Lamia, S.; Phillips, T.; O'Meara, M. J.; Davis, C. S.; Brooks, S. V.; Akbar, M.; Millar, N. L.; Killian, M. L.; Abraham, A. C.
10.1101/2025.01.31.635920 — pathology — Posted on 2025-02-01
5009 Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4
Sanchez, G. J.; Liu, Z.; Hunter, S.; Xu, Q.; Westfall, J. T. V.; Wheeler, G.; Toomey, C.; Taatjes, D.; Allen, M. A.; Dowell, R. D.; Liu, X.
10.1101/2025.01.29.635612 — cancer biology — Posted on 2025-02-01
5010 c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation
Bakırdögen, D.; Görgülü, K.; Xin, J.; Alcala, S.; Ruiz-Canas, L.; Frank, K.; Wu, N.; Diakopoulos, K. N.; Dai, C.; Öztürk, H.; Demircioglu, D.; Peschke, K.; Ranjan, R.; Fusco, F.; Martinez-Useros, J.; Fernandez-Acenero, M. J.; Chhabra, N. F.; Lopez-Gil, J. C.; Ai, J.; Ruess, D. A.; Kaya-Aksoy, E.; Steiger, K.; Schmidt, F.; Kohlmann, L.; Berninger, A.; Schmid, R. M.; Reichert, M.; Adli, M.; Lesina, M.; Sainz, B.; Algül, H.
10.1101/2025.01.29.635445 — cancer biology — Posted on 2025-02-01
5011 What is a differentially expressed gene?
Hoerbst, F.; Sidhu, G. S.; Tomkins, M.; Morris, R. J.
10.1101/2025.01.31.635902 — bioinformatics — Posted on 2025-02-01
5016 Arctic plant species display contrasting levels of chloroplast DNA copy numbers
Kamenova, S.; Moinard, S.; Dwinnell, S. P. H.; Laporte, F.; Coissac, E.
10.1101/2025.01.29.635447 — ecology — Posted on 2025-02-01
5019 Illuminating oncogenic KRAS signaling by multi-dimensional chemical proteomics
Kabella, N.; Bayer, F. P.; Stamatiou, K.; Abele, M.; Sakhteman, A.; Chang, Y.-C.; Wagner, V.; Gabriel, A.; Krumm, J.; Reinecke, M.; Holzner, M.; Aigner, M.; The, M.; Hahne, H.; Bassermann, F.; Ludwig, C.; Vagnarelli, P.; Kuster, B.
10.1101/2025.01.30.635627 — cell biology — Posted on 2025-02-01
5020 Characterisation of DMPK and MBNL1 expression in cell models of Myotonic Dystrophy: A platform for drug screening
Lopez-Martinez, A.; Martin-Gonzalez, S.; Torres-Conde, N.; Alcala-Manso, N.; Al-Ani, A.; Lopez de Munain, A.; Bigot, A.; Mamchaoui, K.; Nogales-Gadea, G.; Arechavala-Gomeza, V.
10.1101/2025.01.31.632773 — cell biology — Posted on 2025-02-01
5021 Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues
Smith, J. L. M.; Tanner, K.; Devine, J.; Monzel, A. S.; Cohen, A. A.; Picard, M.
10.1101/2025.01.31.635929 — cell biology — Posted on 2025-02-01
5024 Cellular mechanisms of early brain overgrowth in autistic children: elevated levels of GPX4 and resistance to ferroptosis
Chen, S.; Shcherbina, A.; Schafer, S. T.; Mattingly, Z. A.; Ramesh, J.; Narayanan, C.; Banerjee, S.; Heath, B.; Regester, M.; Chen, I.; Thakurela, S.; Hallmayer, J.; O'Hara, R.; Solomon, M.; Nordahl, C. W.; Amaral, D. G.; Chetty, S.
10.1101/2025.01.30.635706 — neuroscience — Posted on 2025-02-01
5025 Geometric influences on the regional organization of the mammalian brain
Pang, J. C.; Robinson, P. A.; Aquino, K. M.; Levi, P. T.; Holmes, A.; Markicevic, M.; Shen, X.; Funck, T.; Palomero-Gallagher, N.; Kong, R.; Yeo, B. T. T.; Tiego, J.; Bellgrove, M. A.; Constable, R. T.; Lake, E. M.; Breakspear, M.; Fornito, A.
10.1101/2025.01.30.635820 — neuroscience — Posted on 2025-02-01
5027 Action features dominate cortical representation during natural vision
Jung, H.; Han, X.; Ma, F.; Han, J.; Shokeen, D.; Uden, C. V.; Hanson, I.; Connolly, A. C.; Haxby, J. V.; Nastase, S. A.
10.1101/2025.01.30.635800 — neuroscience — Posted on 2025-02-01
5029 Transcriptional network analysis of PTEN protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Rondon-Lorefice, I.; Lopez, J. I.; Ugalde-Olano, A.; Zufiaurre, M.; Astobiza, I.; Garcia-Longarte, S.; Zabala, A.; Rey, S.; Santos-Martin, A.; Unda, M.; Loizaga-Iriarte, A.; Graupera, M.; Nuciforo, P.; Carracedo, A.; Mendizabal, I.
10.1101/2025.01.31.635608 — cancer biology — Posted on 2025-02-01
5031 VIVIDHA: Variant Prediction and Visualization Interface for Dynamic High-throughput Analysis
Barasiya, T.; Bharti, N.; Gadhari, R.; Bayaskar, A.; Jain, S.; Saxena, A.; Kasibhatla, S. M.; Joshi, R.
10.1101/2025.01.29.635418 — bioinformatics — Posted on 2025-02-01
5032 Predicting coarse-grained representations of biogeochemical cycles from metabarcoding data
Belcour, A.; Megy, L.; Stephant, S.; Michel, C.; Rad, S.; Bombach, P.; Dopffel, N.; de Jong, H.; Ropers, D.
10.1101/2025.01.30.635649 — bioinformatics — Posted on 2025-02-01
5034 Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish
Costa, E. K.; Chen, J.; Guldner, I. H.; Mboning, L.; Schmahl, N.; Tsenter, A.; Wu, M.-R.; Moran-Losada, P.; Bouchard, L. S.; Wang, S.; Singh, P. P.; Pellegrini, M.; Brunet, A.; Wyss-Coray, T.
10.1101/2025.01.28.635350 — genomics — Posted on 2025-02-01