bioRxiv directory

Zacharia, A.; Pal, R. R.; Katsowich, N.; Mannully, C. T.; ibrahim, a.; Alfandary, S.; Serruya, R.; Baidya, A.; Ben-Yehuda, S.; Rosenshine, I.; Moussaieff, A.

10.1101/2020.12.17.423234 — systems biology — Posted on 2022-02-28

3 Computational and experimental studies of the breathing motion of a protein loop: implications in PfAMA1-PfRON2 late-stage binding event

Sinha, S.; Biswas, A.; Mondal, J.; Mandal, K.

10.1101/2021.10.10.463826 — biochemistry — Posted on 2022-02-28

4 Why link diverse citizen science surveys? Widespread arboreal habits of a terrestrial amphibian revealed by mammalian tree surveys in Britain

Petrovan, S.; Al-Fulaij, N.; Christie, A.; Andrews, H.

10.1101/2022.02.27.482211 — ecology — Posted on 2022-02-28

5 Aging-regulated TUG1 is dispensable for endothelial cell function

Gimbel, A. T.; Koziarek, S.; Theodorou, K.; Schulz, J. F.; Stanicek, L.; Ali, T.; Günther, S.; Kumar, S.; Jo, H.; Hübner, N.; Maegdefessel, L.; Dimmeler, S.; van Heesch, S.; Boon, R. A.

10.1101/2022.02.27.482212 — cell biology — Posted on 2022-02-28

6 Spatially Resolved Transcriptomics for Evaluation of Intracranial Vessels in a Rabbit Model: Proof of Concept

Zabriskie, M. S.; Cooke, D. L.; Wang, C.; Alexander, M. D.

10.1101/2022.02.09.479726 — cell biology — Posted on 2022-02-28

7 Cortical ripples in humans

Dickey, C. W.; Verzhbinsky, I. A.; Jiang, X.; Rosen, B. Q.; Kajfez, S.; Eskandar, E. N.; Gonzalez-Martinez, J.; Cash, S. S.; Halgren, E.

10.1101/2021.05.11.443637 — neuroscience — Posted on 2022-02-28

8 The brain integrates proprioceptive information to ensure robust locomotion

Santuz, A.; Laflamme, O.; Akay, T.

10.1101/2021.04.28.441796 — neuroscience — Posted on 2022-02-28

9 Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models.

Brown, B. J.; Boekell, K. L.; Stotter, B. R.; Talbot, B. E.; Schlondorff, J. S.

10.1101/2022.02.11.479954 — physiology — Posted on 2022-02-28

10 Electrical Stimulated GLUT4 Signaling Attenuates Critical Illness-Associated Muscle Wasting

Addinsall, A. B.; Cacciani, N.; Backeus, A.; Hedstrom, Y.; Shevchenko, G.; Bergquist, J.; Larsson, L.

10.1101/2021.11.11.468054 — physiology — Posted on 2022-02-28

11 Intermittent compression increases flow through a gel: a mechanical model perhaps relevant to flow of cerebrospinal fluid

Hale, M. G.; Coles, J. A.

10.1101/2021.12.30.474515 — physiology — Posted on 2022-02-28

12 Tie-lines reveal interactions driving heteromolecular condensate formation

Qian, D.; Welsh, T. J.; Erkamp, N. A.; Qamar, S. S.; Nixon-Abell, J.; St George-Hyslop, P.; Michaels, T.; Knowles, T.; Krainer, G.

10.1101/2022.02.22.481401 — biophysics — Posted on 2022-02-28

13 A weighted constraint satisfaction approach to human goal-directed decision making

Li, Y.; McClelland, J. L.

10.1101/2021.10.13.464177 — animal behavior and cognition — Posted on 2022-02-28

14 CRISPR Del/Rei: A simple, flexible and efficient pipeline for scarless genome editing

Wahbeh, M. H.; Feuer, K. L.; Yovo, C.; Rabie, E.; Lam, A.-T.; Abdollahi, S.; Young, L.; Rike, B.; Akul, U.; Avramopoulos, D.

10.1101/2021.01.18.427163 — genetics — Posted on 2022-02-28

15 Uncertainty Quantification in Variable Selection for Genetic Fine-Mapping using Bayesian Neural Networks

Cheng, W.; Ramachandran, S.; Crawford, L.

10.1101/2022.02.23.481675 — genetics — Posted on 2022-02-28

16 DNA, Morphology, and Ecology Resurrect Previously Synonymized Species of North American Stereum and Suggest Extensive Undescribed Global Diversity

DeLong-Duhon, S. G.; Bagley, R. K.; Forbes, A. A.

10.1101/2020.10.16.342840 — evolutionary biology — Posted on 2022-02-28

17 KoT: an automatic implementation of the K/θ method for species delimitation

Spöri, Y.; Stoch, F.; Dellicour, S.; Birky, C. W.; Flot, J.-F.

10.1101/2021.08.17.454531 — evolutionary biology — Posted on 2022-02-28

18 In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states

Melanker, O.; Goloubinoff, P. A.; Schreiber, G.

10.1101/2021.11.30.470542 — evolutionary biology — Posted on 2022-02-28

19 The effect of a temperature-sensitive prophage on the evolution of virulence in an opportunistic bacterial pathogen

Bruneaux, M.; Ashrafi, R.; Kronholm, I.; Laanto, E.; Örmälä-Odegrip, A.-M.; Galarza, J. A.; Chen, Z.; Kubendran Sumathi, M.; Ketola, T.

10.1101/850248 — evolutionary biology — Posted on 2022-02-28

20 The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium

Niedziołka, S. M.; Datta, S.; Uspienski, T.; Baran, B.; Skarzynska, W.; Humke, E. W.; Rohatgi, R.; Niewiadomski, P.

10.1101/2021.09.27.461918 — cell biology — Posted on 2022-02-28

21 Hydrogen production in the presence of oxygen by Escherichia coli K-12

Metcalfe, G. D.; Sargent, F.; Hippler, M.

10.1101/2022.01.11.475878 — microbiology — Posted on 2022-02-28

22 What are the reference strains of Acinetobacter baumannii referring to?

Philippe, C.; Valcek, A.; Whiteway, C.; Robino, E.; Nesporova, K.; Bove, M.; Coenye, T.; De Pooter, T.; De Coster, W.; Strazisar, M.; Kenyon, J. J.; Van der Henst, C.

10.1101/2022.02.27.482139 — microbiology — Posted on 2022-02-28

23 Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons

Kohler, M.; Bengtsson, F.; Stratmann, P.; Roehrbein, F.; Knoll, A.; Albu-Schaeffer, A.; Joerntell, H.

10.1101/2021.07.16.452238 — neuroscience — Posted on 2022-02-28

24 Pax3 repairs a neural circuit through a program of directed axon outgrowth

Jara, J. S.; Avci, H. X.; Kouremenou, J.; Doulazmi, M.; Bakouche, J.; Dubacq, C.; Goyenvalle, C.; Mariani, J.; Lohof, A. M.; Sherrard, R. M.

10.1101/2021.02.25.432898 — neuroscience — Posted on 2022-02-28

25 Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation

Millrine, D.; Cummings, T.; Matthews, S. P.; Peter, J. J.; Magnussen, H.; Macartney, T.; Lamoliatte, F.; Knebel, A.; Kulathu, Y.

10.1101/2022.02.28.482207 — biochemistry — Posted on 2022-02-28

26 ARID1A maintains transcriptionally repressive H3.3 associated with CHD4-ZMYND8 chromatin interactions

Reske, J. J.; Wilson, M. R.; Armistead, B.; Perez, C.; Hrit, J.; Adams, M.; Rothbart, S. B.; Missmer, S. A.; Fazleabas, A. T.; Chandler, R. L.

10.1101/2022.02.27.482165 — genetics — Posted on 2022-02-28

27 Extracellular vesicles and high-density lipoproteins: Exercise and estrogen-responsive small RNA carriers

Karvinen, S. M.; Korhonen, T.-M.; Sievanen, T. O.; Karppinen, J. E.; Juppi, H.-K.; Jakoaho, V.; Kujala, U. M.; Laukkanen, J. A.; Lehti, M.; Laakkonen, E. K.

10.1101/2022.02.28.482100 — molecular biology — Posted on 2022-02-28

28 Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

Ng, W. M.; Fedosyuk, S.; English, S.; Augusto, G.; Berg, A.; Thorley, L.; Segireddy, R. R.; Bowden, T. A.; Douglas, A. D.

10.1101/2022.02.28.482293 — microbiology — Posted on 2022-02-28

29 Knowledge-guided deep learning models of drug toxicity improve interpretation

Hao, Y.; Romano, J. D.; Moore, J. H.

10.1101/2022.02.28.482300 — pharmacology and toxicology — Posted on 2022-02-28

30 "Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis."

Vaishnavi, A.; Juan, J.; Scherzer, M. T.; VanVeen, J. E.; Stehn, C.; Hackett, C. S.; Dupuy, A.; Chmura, S. A.; van der Weyden, L.; Newberg, J. Y.; Mann, K. M.; Liu, A.; Rust, A. G.; Weiss, W. A.; Adams, D.; Grossman, A.; Mann, M. B.; McMahon, M.

10.1101/2022.02.28.482366 — cancer biology — Posted on 2022-02-28

31 A cooperative switch within the KaiC hexamer revealed by cryo-EM

Han, X.; Zhang, D.; Hong, L.; Yu, D.; Wu, Z.; Yang, T.; Rust, M.; Tu, Y.; Ouyang, Q.

10.1101/2022.02.27.481910 — biophysics — Posted on 2022-02-28

32 Stress induced TDP-43 mobility loss independent of stress granules

Streit, L.; Kuhn, T.; Vomhof, T.; Ludolph, A. C.; Weishaupt, J. H.; Gebhardt, J. C. M.; Michaelis, J.; Danzer, K. M.

10.1101/2022.02.28.482242 — biophysics — Posted on 2022-02-28

33 Improvements on Sample Preparation and Peptide Separation for Reduced Peptide Mapping Based Multi-Attribute Method analysis of Therapeutic Monoclonal Antibodies Using Lys-C Digestion

Li, X.; Rawal, B.; Rivera, S.; Letarte, S.; Richardson, D.

10.1101/2022.02.28.482275 — biochemistry — Posted on 2022-02-28

34 Structural analysis of the bacterial amyloid curli

Sleutel, M.; Pradhan, B.; Remaut, H.

10.1101/2022.02.28.482343 — biochemistry — Posted on 2022-02-28

35 Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly-dT termination signals

Girbig, M.; Xie, J.; Groetsch, H.; Libri, D.; Porrua, O.; Mueller, C. W.

10.1101/2022.02.28.482286 — biochemistry — Posted on 2022-02-28

36 Mechanistic insights into the functioning of GMP synthetase: a two-subunit, allosterically regulated, ammonia tunnelling enzyme

Shivakumaraswamy, S.; Kumar, S.; Bellur, A.; Polisetty, S. D.; Balaram, H.

10.1101/2022.02.27.481963 — biochemistry — Posted on 2022-02-28

37 An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

Jain, K.; Marunde, M. R.; Burg, J. M.; Gloor, S. L.; Joseph, F. M.; Gillespie, Z. B.; Rodriguez, K. L.; Howard, S. A.; Popova, I. K.; Hall, N. W.; Vaidya, A.; Cooke, S. W.; Namitz, K. E. W.; Taylor, B. C.; Weinzapfel, E. N.; Cheek, M. A.; Meiners, M. J.; Krajewski, K.; Cosgrove, M. S.; Young, N. L.; Keogh, M.-C.; Strahl, B. D.

10.1101/2022.02.28.482307 — biochemistry — Posted on 2022-02-28

38 Dual species transcriptomics reveals core metabolic and immunologic processes in the interaction between primary human neutrophils and Neisseria gonorrhoeae strains

Edwards, V. L.; Potter, A. D.; D'Mello, A.; Gray, M. C.; Shetty, A. C.; Zhao, X.; Hill, K. M.; Ragland, S. A.; Criss, A. K.; Tettelin, H.

10.1101/2022.02.28.482360 — genomics — Posted on 2022-02-28

39 Integrative analysis of transcriptomics in human craniofacial development reveals novel candidate disease genes

Yankee, T. N.; Wilderman, A.; Winchester, E. W.; VanOudenhove, J.; Cotney, J.

10.1101/2022.02.28.482338 — genomics — Posted on 2022-02-28

40 A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging

Wang, L.; Wu, C.; Peng, W.; Zhou, Z.; Zeng, J.; Li, X.; Yang, Y.; Yu, S.; Zou, Y.; Huang, M.; Liu, C.; Chen, Y.; Li, Y.; Ti, P.; Liu, W.; Gao, Y.; Zheng, W.; Gao, S.; Lu, Z.; Ren, P.-G.; Ng, H. L.; He, J.; Chen, S.; Xu, M.; Li, Y.; Chu, J.

10.1101/2022.02.27.482140 — molecular biology — Posted on 2022-02-28

41 First report of kdr L1014F and ace-1 G119S insecticide resistance in Belgian Culex mosquitoes

Wang, L.; Soto, A.; Remue, L.; De Coninck, L.; Verwimp, S.; Bouckaert, J.; Vanwinkel, M.; Matthijnssens, J.; Delang, L.

10.1101/2022.02.28.482257 — molecular biology — Posted on 2022-02-28

42 Pleiotropic effects on E. coli physiology of the AraC-like regulator from prophage origin, AppY

Derdouri, N.; Ginet, N.; Denis, Y.; ANSALDI, M.; Battesti, A.

10.1101/2022.02.28.482378 — microbiology — Posted on 2022-02-28

43 Synthetic oxepanoprolinamide iboxamycin is highly active against human pathogen Listeria monocytogenes

Brodiazhenko, T.; Turnbull, K. J.; Wu, K. J. Y.; Takada, H.; Tresco, B. I. C.; Tenson, T.; Myers, A.; Hauryliuk, V.

10.1101/2022.02.28.482263 — microbiology — Posted on 2022-02-28

44 Complex extracellular biology drives surface competition in Bacillus subtilis

Jautzus, T.; van Gestel, J.; Kovacs, A. T.

10.1101/2022.02.28.482363 — microbiology — Posted on 2022-02-28

45 Macrolide therapy in Pseudomonas aeruginosa infections causes uL4 ribosomal protein mutations leading to high-level resistance

Goltermann, L.; Andersen, K. L.; Johansen, H. K.; Molin, S.; La Rosa, R.

10.1101/2022.02.28.482231 — microbiology — Posted on 2022-02-28

46 A nepenthesin insert allosterically controls catalysis in the malaria parasite protease plasmepsin V

Polino, A. J.; Miller, J. J.; Bhakat, S.; Bobba, S.; Bowman, G. R.; Goldberg, D. E.

10.1101/2022.02.28.482356 — microbiology — Posted on 2022-02-28

47 RNA fluorescence in situ hybridization (FISH) to visualize microbial colonization and infection in the Caenorhabditis elegans intestines

Rivera, D.; Lazetic, V.; Troemel, E. R.; Luallen, R. J.

10.1101/2022.02.26.482129 — microbiology — Posted on 2022-02-28

48 Mycobacterial Serine/Threonine phosphatase PstP is phospho-regulated and localized to mediate control of cell wall metabolism

Shamma, F.; Rego, E. H.; Boutte, C.

10.1101/2022.02.28.482390 — microbiology — Posted on 2022-02-28

49 Achieving pan-microbiome biological insights via the dbBact knowledge base

Amir, A.; Ozel, E.; Haberman, Y.; Shental, N.

10.1101/2022.02.27.482174 — microbiology — Posted on 2022-02-28

50 Enabling spatiotemporal regulation within biomaterials using DNA reaction- diffusion waveguides

Dorsey, P. J.; Scalise, D.; Schulman, R.

10.1101/2022.02.26.482105 — synthetic biology — Posted on 2022-02-28

51 Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

Sherrill, L. M.; Joya, E. E.; Walker, A.; Roy, A.; Alhammad, Y. M.; Atobatele, M.; Wazir, S.; Abbas, G.; Keane, P.; Zhuo, J.; Leung, A.; Johnson, D. K.; Lehtio, L.; Fehr, A.; Ferraris, D. V.

10.1101/2022.02.27.482176 — biochemistry — Posted on 2022-02-28

52 Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

Zakharchenko, A.; Rock, C.; Thomas, T.; Keeney, S.; Hall, E.; Takano, H.; Krieger, A.; Ferrari, G.; Levy, R.

10.1101/2022.02.28.482351 — biochemistry — Posted on 2022-02-28

53 Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape

Hunter, B.; Benoit, M. P. M. H.; Asenjo, A. B.; Doubleday, C.; Daria, T.; Sosa, H. S.; Allingham, J. S.

10.1101/2022.02.28.480783 — biochemistry — Posted on 2022-02-28

54 Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

Ohashi, H.; Hishiki, T.; Akazawa, D.; Kim, K. S.; Woo, J.; Shionoya, K.; Tsuchimoto, K.; Iwanami, S.; Moriyama, S.; Kinoshita, H.; Yamada, S.; Kuroda, Y.; Yamamoto, T.; Kishida, N.; Watanabe, S.; Hasegawa, H.; Ebihara, H.; Suzuki, T.; Maeda, K.; Fukushi, S.; Takahashi, Y.; Iwami, S.; Watashi, K.

10.1101/2022.02.27.482147 — microbiology — Posted on 2022-02-28

55 An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

Madden, P. J.; Thomas, Y.; Blair, R. V.; Samer, S.; Doyle, M.; Midkiff, C. C.; Becker, M. E.; Arif, M. S.; McRaven, M. D.; Simons, L. M.; Carias, A. M.; Martinelli, E.; Lorenzo-Redondo, R.; Hultquist, J. F.; Villinger, F. J.; Veazey, R. S.; Hope, T. J.

10.1101/2022.02.25.481974 — immunology — Posted on 2022-02-28

56 A strategy to optimize the peptide-based inhibitors against different mutants of the spike protein of SARS-CoV-2

Priya, P.; Basit, A.; Bandyopadhyay, P.

10.1101/2022.02.27.482153 — biophysics — Posted on 2022-02-28

57 Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

Ma, H.; Tseng, C.-T. K.; Zong, H.; Liao, Y.; Ke, Y.; Tang, H.; Wang, L.; Wang, Z.; He, Y.; Chang, Y.; Wang, S.; Drelich, A.; Hsu, J.; Tat, V.; Yuan, Y.; Wu, M.; Liu, J.; Yue, Y.; Xu, W.; Zhang, X.; Wang, Z.; Yang, L.; Chen, H.; Bian, Y.; Zhang, B.; Yin, H.; Chen, Y.; Zhang, E.; Zhang, X.; Gilly, J.; Sun, T.; Han, L.; Xie, Y.; Jiang, H.; Zhu, J.

10.1101/2022.02.25.482049 — cell biology — Posted on 2022-02-28

58 Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies

De Bastiani, M. A.; Bellaver, B.; Brum, W. S.; Guerini de Souza, D.; C. L. Ferreira, P.; S. Rocha, A.; Povala, G.; Ferrari-Souza, J. P.; L. Benedet, A.; J. Ashton, N.; K. Karikari, T.; Zetterberg, H.; Blennow, K.; Rosa-Neto, P.; Pascoal, T. A.; Zimmer, E. R.; Alzheimer's Disease Neuroimaging Initiative,

10.1101/2022.02.25.481812 — neuroscience — Posted on 2022-02-28

59 Fast and functionally specific cortical thickness changes induced by visual stimulation

Zaretskaya, N.; Fink, E.; Arsenovic, A.; Ischebeck, A.

10.1101/2022.02.25.482013 — neuroscience — Posted on 2022-02-28

60 The Development of 2-stage Microfermentation Protocols for High Throughput Cell Factory Evaluations

Li, S.; Ye, Z.; Moreb, E. A.; Menacho Melgar, R.; Lynch, M. D.

10.1101/2022.02.25.481916 — synthetic biology — Posted on 2022-02-28

61 Photizo: an open-source library for cross-sample analysis of FTIR spectroscopy data

Grant-Peters, M.; Rich-Griffin, C.; Grant-Peters, J. E.; Cinque, G.; Dendrou, C. A.

10.1101/2022.02.25.481930 — bioinformatics — Posted on 2022-02-28

62 Automated, Reproducible Investigation of gene set Differential Enrichment via the AUTO-go framework

Sperandio, E.; Grassucci, I.; D'Ambrosio, L.; Pallocca, M.

10.1101/2022.02.25.482003 — bioinformatics — Posted on 2022-02-28

63 Optimization of Neuroprosthetic Vision via End-to-end Deep Reinforcement Learning

Kücükoglu, B.; Rueckauer, B.; Ahmad, N.; de Ruyter van Steveninck, J.; Güclü, U.; van Gerven, M.

10.1101/2022.02.25.482017 — bioengineering — Posted on 2022-02-28

64 The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

van der Meer, D.; Gurholt, T. P.; Sonderby, I. E.; Shadrin, A.; Hindley, G. F.; Rahman, Z.; Glaso de Lange, A.-M.; Frei, O.; Leinhard, O. D.; Linge, J.; Simon, R.; Westlye, L. T.; Halvorsen, S.; Dale, A.; Karlsen, T. H.; Kaufmann, T.; Andreassen, O. A.

10.1101/2022.02.24.481887 — genomics — Posted on 2022-02-28

65 Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

Zhang, F.; Jonsson, A. H.; Nathan, A.; Wei, K.; Millard, N.; Xiao, Q.; Gutierrez-Arcelus, M.; Apruzzese, W.; Watts, G. F. M.; Weisenfeld, D.; Kang, J. B.; Rumker, L.; Mears, J.; Slowikowski, K.; Weinand, K.; Orange, D. E.; Rangel-Moreno, J.; Geraldino-Pardilla, L.; Deane, K. D.; Tabechian, D.; Ceponis, A.; Firestein, G. S.; Maybury, M.; Sahbudin, I.; Ben-Artzi, A.; Mandelin, A. M.; Nerviani, A.; Rivellese, F.; Pitzalis, C.; Hughes, L. B.; Horowitz, D.; DiCarlo, E.; Gravallese, E. M.; Boyce, B. F.; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus

10.1101/2022.02.25.481990 — genomics — Posted on 2022-02-28

66 Increased birth rank of homosexual males: disentangling the older brother effect and sexual antagonism hypothesis

Raymond, M.; Turek, D.; Durand, V.; Nila, S.; Suryobroto, B.; Vadez, J.; Barthes, J.; Apostolou, M.; Crochet, P.-A.

10.1101/2022.02.22.481477 — evolutionary biology — Posted on 2022-02-28

67 Data based slurry treatment decision tree to minimize antibiotic resistance and pathogen transfer while maximizing nutrient recycling

Do, T. T.; Nolan, S.; Hayes, N.; OFlaherty, V.; Burgess, C.; Brennan, F.; Walsh, F.

10.1101/2022.02.25.481976 — microbiology — Posted on 2022-02-28

68 Memory Consolidation with Orthogonal Gradients for avoiding Catastrophic Forgetting

Kanagamani, T.; Krishnamurthy, R.; Chakravarthy, S.; Ravindran, B.; Menon, R. N.

10.1101/2022.02.25.481890 — neuroscience — Posted on 2022-02-28

69 LipidMS 3.0: an R-package and a web-based tool for LC-MS/MS data processing and lipid annotation

Alcoriza-Balaguer, M. I.; Garcia-Canaveras, J. C.; Ripoll-Esteve, F. J.; Lahoz, A.

10.1101/2022.02.25.476005 — bioinformatics — Posted on 2022-02-28

70 Maturation of cortical endoplasmic reticulum clusters in the mouse oocyte: changes at fertilization.

Wang, H.; Christenson, L. K.; Kinsey, W. H.

10.1101/2022.02.28.482320 — developmental biology — Posted on 2022-02-28

71 RNA binding is essential for NONO condensates to modulate pre-mRNA processing in neuroblastoma

Zhang, S.; Cooper, J. A.; Chong, Y. S.; Naveed, A.; Mayoh, C.; Jayatillek, N.; Liu, T.; Amos, S.; Kobelke, S.; Marshall, A. C.; Meers, O.; Choi, Y. S.; Bond, C. S.; Fox, A. H.

10.1101/2022.02.28.482217 — cell biology — Posted on 2022-02-28

72 Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo

Smith, J. G.; Koronowski, K. B.; Sato, T.; Greco, C.; Petrus, P.; Verlande, A.; Chen, S.; Samad, M.; Deyneka, E.; Mathur, L.; Blazev, R.; Molendijk, J.; Mortimer, T.; Kumar, A.; Deryagin, O.; Vaca-Dempere, M.; Liu, P.; Orlando, V.; Parker, B. L.; Baldi, P.; Welz, P.-S.; Jang, C.; Masri, S.; Benitah, S. A.; Munoz-Canoves, P.; Sassone-Corsi, P.

10.1101/2022.02.27.482160 — cell biology — Posted on 2022-02-28

73 Loading-Induced Bone Formation is Mediated by Wnt1 Induction in Osteoblast-Lineage Cells

Lawson, L.; Migotsky, N.; Chermside-Scabbo, C.; Shuster, J.; Civitelli, R.; Silva, M.

10.1101/2022.02.28.482178 — cell biology — Posted on 2022-02-28

74 Telomerase deficiency in humans is associated with systemic age-related changes in energy metabolism

James, E. N.; Sagi-Kiss, V.; Bennett, M.; Mycielska, M.; Lee Pemg, K.-N.; Roberts, T.; Matta, S.; Dokal, I.; Bundy, J. G.; Parkinson, E. K.

10.1101/2022.02.28.481982 — cell biology — Posted on 2022-02-28

75 Adenosine A2A Receptor (A2AR) agonists improve survival in K28-hACE2 mice following SARS CoV-2 infection

Mann, B. J.; Chhabra, P.; Ma, M.; Brovero, S. G.; Jones, M. K.; Linden, J. M.; Brayman, K. L.

10.1101/2022.02.25.481997 — microbiology — Posted on 2022-02-28

76 COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

Sinha, S.; Castillo, V.; Espinoza, C. R.; Tindle, C.; Fonseca, A. G.; Dan, J. M.; Katkar, G. D.; Das, S.; Sahoo, D.; Ghosh, P.

10.1101/2021.11.28.470269 — immunology — Posted on 2022-02-28

77 Decoding the sound of hand-object interactions in primary somatosensory cortex

Bailey, K. M.; Giordano, B. L.; Kaas, A.; Smith, F. W.

10.1101/732669 — neuroscience — Posted on 2022-02-28

78 NMDAr BLOCKING BY MK801 ALTERS HIPPOCAMPAL AND PREFRONTAL CORTEX OSCILLATIONS AND IMPAIRS SPATIAL WORKING MEMORY IN MICE.

Abad-Perez, P.; Martinez, L. M.; Borrell, V.; Redondo, R.; Brotons-Mas, J. R.

10.1101/2021.09.22.461383 — neuroscience — Posted on 2022-02-28

79 Phylogenomic Testing of Root Hypotheses

Tria, F. D. K.; Dagan, T.; Landan, G.

10.1101/758581 — evolutionary biology — Posted on 2022-02-28

80 A CNN model with feature integration for MI EEG subject classification in BMI

Roy, A. M.

10.1101/2022.01.05.475058 — neuroscience — Posted on 2022-02-28

81 Widening the landscape of transcriptional regulation of algal photoprotection

Arend, M.; Yuan, Y.; Omranian, N.; Nikoloski, Z.; Petroutsos, D.

10.1101/2022.02.25.482034 — plant biology — Posted on 2022-02-28

82 Detection of nervous necrosis virus RGNNV genotype in pearl gentian grouper (Epinephelus lanceolatus male x E. fuscoguttatus female) fry imported to Thailand

Jungi, S. V.; Sangsuriya, P.; Taengphu, S.; Phiwsaiya, K.; Sonthi, M.; Nuangsaeng, B.; Salin, K. R.; Senapin, S.; Dong, H. T.

10.1101/2022.02.24.481889 — pathology — Posted on 2022-02-28

83 Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors

Campanacci, V.; Urvoas, A.; Ammar Khodja, L.; Aumont-Nicaise, M.; Noiray, M.; Lachkar, S.; Curmi, P. A.; Minard, P.; Gigant, B.

10.1101/2021.10.19.464980 — biochemistry — Posted on 2022-02-28

84 Why link diverse citizen science surveys? Widespread arboreal habits of a terrestrial amphibian revealed by mammalian tree surveys in Britain

Petrovan, S.; Al-Fulaij, N.; Christie, A.; Andrews, H.

10.1101/2022.02.27.482211 — ecology — Posted on 2022-02-28

85 Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Fang, Z.; Peng, L.; Filler, R.; Suzuki, K.; McNamara, A.; Lin, Q.; Renauer, P. A.; Yang, L.; Menasche, B.; Sanchez, A.; Ren, P.; Xiong, Q.; Strine, M.; Clark, P.; Lin, C.; Ko, A. I.; Grubaugh, N. D.; Wilen, C. B.; Chen, S.

10.1101/2022.02.14.480449 — immunology — Posted on 2022-02-28

86 Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE

Borges, F. d. S.; Moreira, J. V. S.; Takarabe, L. M.; Lytton, W. W.; Dura-Bernal, S.

10.1101/2022.02.03.479029 — neuroscience — Posted on 2022-02-28

87 Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus

Cao, R.; Wang, J.; Lin, C.; Falco, E. D.; Peter, A.; Rey, H. G.; DiCarlo, J.; Todorov, A.; Rutishauser, U.; Li, X.; Brandmeir, N.; Wang, S.

10.1101/2020.09.01.278283 — neuroscience — Posted on 2022-02-28

88 Patterns of connectome variability in autism across five functional activation tasks. Findings from the LEAP project

Looden, T.; Floris, D. L.; Llera Arenas, A.; Chauvin, R. J.; Charman, T.; Banaschewski, T.; Murphy, D.; Marquand, A. F.; Buitelaar, J. K.; Beckmann, C. F.; the AIMS-2-TRIALS group,

10.1101/2022.02.22.481408 — neuroscience — Posted on 2022-02-28

89 The role of the angular gyrus in semantic cognition - A synthesis of five functional neuroimaging studies

Kuhnke, P.; Chapman, C. A.; Cheung, V. K. M.; Turker, S.; Graessner, A.; Martin, S.; Williams, K. A.; Hartwigsen, G.

10.1101/2021.12.21.473704 — neuroscience — Posted on 2022-02-28

90 A novel nongenetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosis

Gaul, S.; Shahzad, K.; Medert, R.; Gadi, I.; Meader, C.; Schumacher, D.; Wirth, A.; Ambreen, S.; Fatima, S.; Boeckel, J.-N.; Khawaja, H.; Haas, J.; Brune, M.; Nawroth, P. P.; Isermann, B.; Laufs, U.; Freichel, M.

10.1101/2021.11.11.468191 — pharmacology and toxicology — Posted on 2022-02-28

91 A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

Zivanov, J.; Oton, J.; Ke, Z.; Qu, K.; Morado, D.; Castano-Diez, D.; von Kügelgen, A.; Bharat, T.; Briggs, J.; Scheres, S.

10.1101/2022.02.28.482229 — biophysics — Posted on 2022-02-28

92 Interpretable deep learning model reveals subsequences of various functions for long non-coding RNA identification

Lin, R.; Wichadakul, D.

10.1101/2022.02.11.479495 — bioinformatics — Posted on 2022-02-28

93 Vocal tract allometry in a mammalian vocal learner

de Reus, K.; Carlson, D.; Lowry, A.; Gross, S.; Garcia, M.; Salazar-Casals, A.; Rubio-Garcia, A.; Ravignani, A.

10.1101/2021.10.29.466455 — animal behavior and cognition — Posted on 2022-02-28

94 Ecology dictates the value of memory for foraging bees

Pull, C. D.; Petkova, I.; Watrobska, C.; Pasquier, G.; Pere Fernandez, M.; Leadbeater, E.

10.1101/2021.09.06.458851 — animal behavior and cognition — Posted on 2022-02-28

95 RNA targeting with CRISPR-Cas13a facilitates bacteriophage genome engineering

Guan, J.; Oromi-Bosch, A.; Mendoza, S. D.; Karambelkar, S.; Berry, J.; Bondy-Denomy, J.

10.1101/2022.02.14.480438 — microbiology — Posted on 2022-02-28

96 Value, confidence, deliberation: a functional partition of the medial prefrontal cortex demonstrated across rating and choice tasks

Clairis, N.; Pessiglione, M.

10.1101/2020.09.17.301291 — neuroscience — Posted on 2022-02-28

97 Organotopic organization of the cervical vagus nerve

Thompson, N.; Ravagli, E.; Mastitskaya, S.; Iacoviello, F.; Stathopoulou, T.-R.; Perkins, J.; Shearing, P. R.; Aristovich, K.; Holder, D.

10.1101/2022.02.24.481810 — neuroscience — Posted on 2022-02-28

98 Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

Merour, E.; Hmidan, H.; Marie, C.; Helou, P.-H.; Lu, H.; Potel, A.; Hure, J.-B.; Clavairoly, A.; Shih, Y. P.; Goudarzi, S.; Dussaud, S.; Ravassard, P.; Hafizi, S.; Lo, S. H.; Hassan, B. A.; Parras, C.

10.1101/2022.02.25.481980 — neuroscience — Posted on 2022-02-28

99 Deciphering the developmental patterns of white matter tracts in a diffusion MRI based fetal brain atlas

Chen, R.; Sun, C.; Liu, T.; Liao, Y.; Wang, J.; Sun, Y.; Zhang, Y.; Wang, G.; Wu, D.

10.1101/2022.02.28.481882 — neuroscience — Posted on 2022-02-28

100 Variation of sexual dimorphism of wing shape in the family Dolichopodidae (Diptera)

Chursina, M. A.; Maslova, O. O.

10.1101/2022.02.25.481985 — zoology — Posted on 2022-02-28

101 A General Biphasic-Bodyweight Model for Scaling Basal Metabolic Rate, Glomerular Filtration Rate and Drug Clearance from Birth to Adulthood

Hu, T.-M.

10.1101/2021.07.25.453668 — pharmacology and toxicology — Posted on 2022-02-28

102 Molecular and mineral responses of corals grown under artificial Calcite Sea conditions

Conci, N.; Griesshaber, E.; Rivera, R.; Schmahl, W. W.; Vargas, S.; Wörheide, G.

10.1101/2022.02.25.481970 — paleontology — Posted on 2022-02-28

103 Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia

Wagstaff, M.; Tsaponina, O.; Caalim, G.; Greenfield, H.; Milton-Harris, L.; Mancini, E. J.; Blair, A.; Heesom, K. J.; Tonks, A.; Darley, R. L.; Roberts, S. G.; Morgan, R. G.

10.1101/2021.11.06.467095 — cancer biology — Posted on 2022-02-28

104 Slowing down an analyte in a nanopore

Sampath, G.

10.1101/2021.01.11.426231 — bioengineering — Posted on 2022-02-28

105 No leeway to enhance carbon sequestration and stock capacity via changes to forest management

Dalmonech, D.; Marano, G.; Amthor, J.; Cescatti, A.; Lindner, M.; Trotta, C.; Collalti, A.

10.1101/2022.02.10.479900 — ecology — Posted on 2022-02-28

106 Machine learning meets classical computer vision for accurate cell identification

Karimi, E.; Rezanejad, M.; Fiset, B.; Perus, L.; McDowell, S. A. C.; Arabzadeh, A.; Beugnot, G.; Siegel, P.; Guiot, M.-C.; Quail, D. F.; Siddiqi, K.; Walsh, L. A.

10.1101/2022.02.27.482183 — cell biology — Posted on 2022-02-28

107 The decision to develop into αβ or γδ T cells is pre-programmed in distinct subpopulations of DN1 thymocytes

Oh, S.; Tomei, S.; Liu, X.; Naik, S. H.; Gray, D. H.; Chong, M. M.

10.1101/2022.02.25.481936 — immunology — Posted on 2022-02-28

108 Conserved neuropeptidergic regulation of intestinal integrity in invertebrate models of aging

Singh, A.; Kaduskar, B.; Reddy, K. C.; Kumsta, C.; Bier, E.; Hansen, M.; Chalasani, S. H.

10.1101/2022.02.24.481867 — neuroscience — Posted on 2022-02-28

109 A molecular mechanism for high salt taste in Drosophila

McDowell, S. A. T.; Stanley, M.; Gordon, M. D.

10.1101/2022.02.25.481885 — neuroscience — Posted on 2022-02-28

110 TMS over dorsolateral prefrontal cortex affects the timing of motor imagery but not overt action: further support for the Motor-Cognitive model

Martel, M.; Glover, S.

10.1101/2022.02.25.481944 — neuroscience — Posted on 2022-02-28

111 Opioid Antagonism in Humans: A Primer on Optimal Dose and Timing for Central Mu-Opioid Receptor Blockade

Trøstheim, M.; Eikemo, M.; Haaker, J.; Frost, J. J.; Leknes, S.

10.1101/2022.02.25.481943 — neuroscience — Posted on 2022-02-28

112 Morphometric characters in the taxonomic recognition of the species of Dolichopus pennatus group (Diptera: Dolichopodidae)

Chursina, M. A.; Selivanova, O. V.

10.1101/2022.02.25.481977 — zoology — Posted on 2022-02-28

113 Modulation of nuclear and cytoplasmic mRNA fluctuations by time-dependent stimuli: analytical distributions

Filatova, T.; Popovic, N.; Grima, R.

10.1101/2022.02.25.481898 — systems biology — Posted on 2022-02-28

114 Quantitative contribution of the spacer length in the supercoiling-sensitivity of bacterial promoters

Forquet, R.; Nasser, W.; Reverchon, S.; Meyer, S.

10.1101/2022.02.25.481925 — bioinformatics — Posted on 2022-02-28

115 Information-Content-Informed Kendall-tau Correlation: Utilizing Missing Values

Flight, R. M.; Bhatt, P. S.; Moseley, H. N. B.

10.1101/2022.02.24.481854 — bioinformatics — Posted on 2022-02-28

116 Agent-based models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes.

Leighow, S. M.; Landry, B.; Lee, M. J.; Peyton, S. R.; Pritchard, J. R.

10.1101/2022.02.25.481999 — bioengineering — Posted on 2022-02-28

117 Deep Augmentation for Electrode Shift Compensation in Transient-phase High-density Electromyographical Neural Interfaces: Towards Application in Neurorobotics

Sun, T.; Libby, J.; Rizzo, J.; Atashzar, S. F.

10.1101/2022.02.25.481922 — bioengineering — Posted on 2022-02-28

118 Pangenome evolution in environmentally transmitted symbionts of deep-sea mussels is governed by vertical inheritance

Romero Picazo, D.; Werner, A.; Dagan, T.; Kupczok, A.

10.1101/2021.11.12.468352 — evolutionary biology — Posted on 2022-02-27

119 Temporal matches and mismatches between monarch butterfly and milkweed population changes over the past 12,000 years

Boyle, J.; Strickler, S. R.; Twyford, A.; Ricono, A.; Powell, A.; Zhang, J.; Xu, H.; Dalgleish, H. J.; Jander, G. D.; Agrawal, A.; Puzey, J. R.

10.1101/2022.02.25.481796 — evolutionary biology — Posted on 2022-02-28

120 Biogeographical history shapes evolution of reproduction in a global warming scenario

Santos, M.; Antunes, M.; Grandela, A.; Carromeu-Santos, A.; S. Quina, A.; Santos, M.; Matos, M.; Simoes, P.

10.1101/2022.02.25.481927 — evolutionary biology — Posted on 2022-02-28

121 Fish as model systems to study epigenetic drivers in human self-domestication and neurodevelopmental cognitive disorders

Anastasiadi, D.; Piferrer, F.; Wellenreuther, M.; Benitez-Burraco, A.

10.1101/2022.02.24.481892 — evolutionary biology — Posted on 2022-02-28

122 Basolateral amygdala to insular cortex activity makes sign-tracking behavior insensitive to outcome value

Keefer, S. E.; Kochli, D. E.; Calu, D. J.

10.1101/2022.02.24.481881 — neuroscience — Posted on 2022-02-28

123 Temporally extended and reversible neuronal silencing with Aion

Rodriguez-Rozada, S.; Wietek, J.; Tenedini, F. M.; Sauter, K.; Hegemann, P.; Soba, P.; Wiegert, J. S.

10.1101/2022.02.25.481932 — neuroscience — Posted on 2022-02-28

124 Meta-Analysis of the Functional Neuroimaging Literature with Probabilistic Logic Programming

Abdallah, M.; Iovene, V.; Zanitti, G. E.; Wassermann, D.

10.1101/2022.02.25.481931 — neuroscience — Posted on 2022-02-28

125 Identification of novel leaf rust seedling resistance loci in Iranian bread wheat germplasm using genome-wide association mapping

Delfan, S.; Bihamta, M. R.; Dadrezaei, S. T.; Abbasi, A.; Alipour, H.; Imani, J.; Kogel, K.-H.

10.1101/2022.02.24.481752 — plant biology — Posted on 2022-02-28

126 Accumulation of TERT in Mitochondria Shows Two Opposing Effects on Apoptosis

Ebata, H.; Shima, T.; Iizuka, R.; Uemura, S.

10.1101/2021.12.21.473585 — cell biology — Posted on 2022-02-27

127 Transcranial photobiomodulation enhances visual working memory capacity in humans

Zhao, C.; Li, D.; Kong, Y.; Liu, H.; Hu, Y.; Niu, H.; Jensen, O.; Li, X.; Liu, H.; Song, Y.

10.1101/2022.02.24.481703 — neuroscience — Posted on 2022-02-27

128 The cardiac TRPA1 channel drives calcium-mediated mechano-arrhythmogenesis

Cameron, B. A.; Stoyek, M. R.; Bak, J. J.; Connolly, M. S.; DeLong, E. A.; Greiner, J.; Peyronnet, R.; Kohl, P.; Quinn, T. A.

10.1101/2020.10.01.321638 — physiology — Posted on 2022-02-27

129 LabGym: quantification of user-defined animal behaviors using learning-based holistic assessment

Hu, Y.; Ferrario, C.; Ghimire, A.; Watson, B.; Iwasaki, K.; White, H.; Xi, Y.; Zhou, J.; Ye, B.

10.1101/2022.02.17.480911 — animal behavior and cognition — Posted on 2022-02-27

130 Destabilization of F-actin by Mechanical Stress Deprivation or Tpm3.1 Inhibition Promotes a Pathological Phenotype in Tendon Cells

Inguito, K. L.; Schofield, M. M.; Faghri, A. D.; Bloom, E.; Heino, M.; Elliott, D.; Parreno, J.

10.1101/2022.02.15.480605 — cell biology — Posted on 2022-02-27

131 Human coronaviruses disassemble processing bodies

Kleer, M.; Mulloy, R. P.; Robinson, C.-A.; Evseev, D.; Bui-Marinos, M. P.; Castle, E. L.; Banerjee, A.; Mubareka, S.; Mossman, K.; Corcoran, J. A.

10.1101/2020.11.08.372995 — microbiology — Posted on 2022-02-27

132 Activation of the neonatal immune system in healthy neonates within hours of birth.

Ariyakumar, G.; Gee, S.; Das, A.; Kamdar, S.; Tribe, R.; Gibbons, D.

10.1101/2022.02.25.481959 — immunology — Posted on 2022-02-27

133 Polyelectrolyte brush bilayers at thermal equilibrium: Density functional theory and molecular dynamic simulations

Edwards, M. J.

10.1101/2022.02.24.481861 — biophysics — Posted on 2022-02-27

134 Meaningful Local Signaling in SA Node Center Identified by Random Matrix Theory

Norris, C. F.; Maltsev, A. V.

10.1101/2022.02.25.482007 — biophysics — Posted on 2022-02-27

135 Protein-protein interaction prediction for targeted protein degradation

Orasch, O.; Weber, N.; Mueller, M.; Amanzadi, A.; Gasbarri, C.; Trummer, C.

10.1101/2022.02.25.481776 — bioinformatics — Posted on 2022-02-27

136 Regional centromeres protect organisms from lethal mutations

Sankaranarayanan, S. R.; Polisetty, S. D.; Dumbrepatil, A.; Jeyaprakash, A. A.; Sanyal, K.

10.1101/2022.02.25.481917 — genetics — Posted on 2022-02-27

137 Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans

Santos, J.; Matos, M.; Flatt, T.; Chelo, I. M.

10.1101/2022.02.26.482130 — evolutionary biology — Posted on 2022-02-27

138 Siderophore production and utilization by microbes in the North Pacific Ocean

Park, J.; Durham, B. P.; Key, R. S.; Groussman, R. D.; Pinedo-Gonzalez, P.; Hawco, N. J.; John, S. G.; Carlson, M. C. G.; Lindell, D.; Juranek, L.; Ferron, S.; Ribalet, F.; Armbrust, E. V.; Ingalls, A. E.; Bundy, R. M.

10.1101/2022.02.26.482025 — ecology — Posted on 2022-02-27

139 Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment.

Silva, N.; Campinho, M. A.

10.1101/2022.02.26.482108 — developmental biology — Posted on 2022-02-27

140 Hypoxia promotes osteogenesis via regulation of the mito-nuclear communication

Pouikli, A.; Maleszewska, M.; Parekh, S.; Nikopoulou, C.; Bonfiglio, J.-J.; Mylonas, C.; Sandoval, T.; Schumacher, A.-L.; Hinze, Y.; Matic, I.; Tessarz, P.

10.1101/2022.02.26.482117 — cell biology — Posted on 2022-02-27

141 Multiomic profiling defines cell fate plasticity of in vitro-derived islets

Augsornworawat, P.; Marquez, E.; Maestas, M. M.; Ishahak, M.; Gale, S. E.; Schmidt, M. D.; Veronese-Paniagua, D. A.; Miller, J. R.; Velazco-Cruz, L.; Millman, J. R.

10.1101/2022.02.26.482126 — cell biology — Posted on 2022-02-27

142 NEDD8 activity is important for direct antigen MHC class I antigen presentation

Vijayasimha, K.; Leestemaker-Palmer, A. L.; Gibbs, J. S.; Yewdell, J. W.; Dolan, B. P.

10.1101/2022.02.25.482016 — immunology — Posted on 2022-02-27

143 Human HLFneg placental erythro-myeloid progenitors give rise to HLA Class IIneg Hofbauer cells

Thomas, J. R.; Appios, A.; Calderbank, E. F.; Zhao, X. X.; Hamilton, R. S.; Moffett, A.; Sharkey, A.; Laurenti, E.; McGovern, N.

10.1101/2022.02.26.482080 — immunology — Posted on 2022-02-27

144 A metabolically engineered bacterium controls autoimmunity by remodeling the pro-inflammatory microenvironment

Das, J. K.; Guo, F.; Hunt, C.; Steinmeyer, S.; Plocica, J. A.; Kobayashi, K. S.; Jayaraman, A.; Ficht, T. A.; Alaniz, R. C.; de Figueiredo, P.; Song, J.

10.1101/2022.02.26.482123 — immunology — Posted on 2022-02-27

145 Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating TGFβ inhibition

Luong, T.; Cukierman, E.

10.1101/2022.02.25.482033 — cancer biology — Posted on 2022-02-27

146 Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP2

Panasawatwong, A.; Pipatpolkai, T.; Tucker, S. J.

10.1101/2022.02.27.482173 — biophysics — Posted on 2022-02-27

147 Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

Singh, A. K.; De Wijngaert, B.; Bijnens, M.; Uyttersprot, K.; Nguyen, H.; Martinez, S. E.; Schols, D.; Herdewijn, P.; Pannecouque, C.; Arnold, E.; Das, K.

10.1101/2022.02.27.482155 — biophysics — Posted on 2022-02-27

148 Transient DNA binding to gapped DNA substrates links DNA sequence to the single-molecule kinetics of protein-DNA interactions

Andrews, R.; Steuer, H.; El-Sagheer, A.; Mazumder, A.; el Sayyed, H.; Shivalingam, A.; Brown, T.; Kapanidis, A. N.

10.1101/2022.02.27.482175 — biophysics — Posted on 2022-02-27

149 Metagenomic binning with assembly graph embeddings

Lamurias, A.; Sereika, M.; Albertsen, M.; Hose, K.; Nielsen, T. D.

10.1101/2022.02.25.481923 — bioinformatics — Posted on 2022-02-27

150 The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

Appel, L.-M.; Grishkovskaya, I.; Benedum, J.; Franke, V.; Polyansky, A.; Neudolt, A.; Wunder, A.; Zagrovic, B.; Akalin, A.; Djinovic-Carugo, K.; Slade, D.

10.1101/2022.02.26.482114 — biochemistry — Posted on 2022-02-27

151 Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Neuropsychiatric Disorders

Bermperidis, T.; Schafer, S.; Gage, F. H.; Sejnowski, T.; Torres, E. B.

10.1101/2022.02.26.482124 — genomics — Posted on 2022-02-27

152 Trophic strategies explain the ocean niches of small eukaryotic phytoplankton

Edwards, K. F.; Li, Q.; McBeain, K. A.; Schvarcz, C. R.; Steward, G. F.

10.1101/2022.02.27.482152 — ecology — Posted on 2022-02-27

153 Rapid estimation of cryptic adult abundance and breeding dynamics in a critically endangered elasmobranch from close-kin mark recapture

Patterson, T. A.; Hillary, R. M.; Feutry, P.; Gunasakera, R.; Marthick, J.; Pillans, R. D.

10.1101/2022.02.24.481858 — ecology — Posted on 2022-02-27

154 Obesity disrupts innate-adaptive immune network patterning in adipose tissue

Dotson, G. A.; Rajapakse, I.; Muir, L. A.

10.1101/2022.02.26.482134 — cell biology — Posted on 2022-02-27

155 Epigenetic signals that direct cell type specific interferon beta response in mouse cells

Muckenhuber, M.; Lander, I.; Müller-Ott, K.; Mallm, J.-P.; Klett, L. C.; Knotz, C.; Hechler, J.; Kepper, N.; Erdel, F.; Rippe, K.

10.1101/2022.02.26.481127 — molecular biology — Posted on 2022-02-27

156 Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

Schwarz, M.; Price, D. A.; Ganaie, S.; Feng, A.; Mishra, N.; Hoehl, R.; Fatma, F.; Stubbs, S.; Whelan, S. P. J.; Cui, X.; Egawa, T.; Leung, D.; Amarasinghe, G.; Hartman, A. L.

10.1101/2022.02.26.482111 — microbiology — Posted on 2022-02-27

157 What are the reference strains of Acinetobacter baumannii referring to?

Philippe, C.; Valcek, A.; Whiteway, C.; Robino, E.; Nesporova, K.; Bove, M.; Coenye, T.; De Pooter, T.; De Coster, W.; Strazisar, M.; Kenyon, J. J.; Van der Henst, C.

10.1101/2022.02.27.482139 — microbiology — Posted on 2022-02-27

158 Identification and characterisation of Klebsiella pneumoniae and Pseudomonas aeruginosa clinical isolates with atypical β-lactam susceptibility profiles using Orbitrap liquid chromatography-tandem mass spectrometry

Takebayashi, Y.; Dulyayangkul, P.; Satapoomin, N.; ISMAH, W. A. K. W. N.; Williams, O. M.; MacGowan, A. P.; Heesom, K. J.; Williams, P. B.; Avison, M. B.

10.1101/2022.02.27.482154 — microbiology — Posted on 2022-02-27

159 Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

Dickey, C. W.; Verzhbinsky, I. A.; Jiang, X.; Rosen, B. Q.; Kajfez, S.; Stedelin, B.; Shih, J. J.; Ben-Haim, S.; Raslan, A. M.; Eskandar, E. N.; Gonzalez-Martinez, J.; Cash, S. S.; Halgren, E.

10.1101/2021.02.23.432582 — neuroscience — Posted on 2022-02-27

160 Activation of the actin/MRTF-A/SRF signalling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation

Faria, L.; Canato, S.; Jesus, T. T.; Goncalves, M.; Guerreiro, P. S.; Lopes, C. S.; Meireles, I.; Morais-de-Sa, E.; Paredes, J.; Janody, F.

10.1101/2022.02.26.481995 — cancer biology — Posted on 2022-02-27

161 Using predictive validity to compare associations between brain damage and behavior

Magnotti, J.; Patterson, J. S.; Schnur, T. T.

10.1101/2022.02.24.481802 — neuroscience — Posted on 2022-02-27

162 Human mesenchymal stem cells and derived extracellular vesicles reduce sensory neuron hyperexcitability and pain-related behaviors in a mouse model of osteoarthritis

Ai, M.; Hotham, W. E.; Pattison, L. A.; Ma, Q.; Henson, F. M.; Smith, E. S. J.

10.1101/2022.02.25.478196 — neuroscience — Posted on 2022-02-27

163 Regional mutational signature activities in cancer genomes

Timmons, C.; Morris, Q.; Harrigan, C. F.

10.1101/2022.01.23.477261 — cancer biology — Posted on 2022-02-27

164 Cryo-EM structure of the Rhodobaca bogoriensis RC-LH1-PufX dimeric complex at 2.9 angstrom

Semchonok, D. A.; Siponen, M. I.; Tueting, C.; Charras, Q.; Kyrilis, F. L.; Sadian, Y.; Jungas, C.; Kastritis, P. L.

10.1101/2022.02.25.481955 — biophysics — Posted on 2022-02-27

165 Genetic immune escape landscape in primary and metastatic cancer

Martinez-Jimenez, F.; Priestley, P.; Shale, C.; Baber, J.; Rozemuller, E.; Cuppen, E.

10.1101/2022.02.23.481444 — genomics — Posted on 2022-02-27

166 A platform of patient-derived microtumors identifies therapeutic vulnerabilities in ovarian cancer.

Anderle, N.; Koch, A.; Gierke, B.; Keller, A.-L.; Staebler, A.; Hartkopf, A.; Brucker, S.; Pawlak, M.; Schenke-Layland, K.; Schmees, C.

10.1101/2021.11.10.468007 — cancer biology — Posted on 2022-02-27

167 Molecular insights into the recognition of acetylated histone modifications by the BRPF2 bromodomain

Barman, S.; Roy, A.; Padhan, J.; Sudhamalla, B.

10.1101/2022.02.20.481182 — biochemistry — Posted on 2022-02-27

Hiller, M.; Indrischek, H.; Hammer, J.; Machate, A.; Hecker, N.; Kirilenko, B.; Roscito, J.; Hans, S.; Norden, C.; Brand, M.

10.1101/2022.02.25.481972 — evolutionary biology — Posted on 2022-02-27

169 ScRNA-seq Expression of IFI27 and APOC2 Identifies Four Alveolar Macrophage Superclusters in Healthy BALF

Li, X.; Kolling, F. W.; Aridgides, D.; Mellinger, D.; Ashare, A.; Jakubzick, C. V.

10.1101/2022.01.30.478325 — immunology — Posted on 2022-02-27

170 Prostate megalin is regulated by serum hormone levels and imports globulin-bound testosterone

Garcia, J.; Krieger, K.; Loitz, C.; Perez, L. M.; Richards, Z. A.; Helou, Y. B.; Kregel, S.; Selada, S.; Mesaros, C. A.; Gann, P.; Willnow, T. E.; Vander Griend, D.; Kittles, R.; Prins, G.; Penning, T.; Nonn, L.

10.1101/2021.11.09.467567 — cancer biology — Posted on 2022-02-27

171 Thermal regime during parental sexual maturation, but not during offspring rearing, modulates DNA methylation in brook charr (Salvelinus fontinalis)

Venney, C. J.; Wellband, K. W.; Normandeau, E.; Houle, C.; Garant, D.; Audet, C.; Bernatchez, L.

10.1101/2022.02.25.481661 — evolutionary biology — Posted on 2022-02-27

172 Orthogonal targeting of KDM6A/B and HDACs mediates potent therapeutic effects in IDH1-mutant glioma

Kayabolen, A.; Yilmaz, E.; Sahin, G. N.; Seker-Polat, F.; Cingoz, A.; Isik, B.; Acar, S.; Karahuseyinoglu, S.; Wakimoto, H.; Cahill, D. P.; Solaroglu, I.; Cribbs, A. P.; Oppermann, U.; Bagci-Onder, T.

10.1101/2020.11.26.400234 — cancer biology — Posted on 2022-02-27

173 Coordination of two opposite flagella allows high-speed swimming and active turning of individual zoospores

Tran, Q. D.; Galiana, E.; Thomen, P.; Cohen, C.; Orange, F.; Peruani, F.; Noblin, X.

10.1101/2021.04.23.441092 — biophysics — Posted on 2022-02-27

174 A loss-of-function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition

Woodard, D. R.; Daniel, S.; Nakahara, E.; Abbas, A.; DiCesare, S. M.; Hulleman, J. D.

10.1101/2022.02.25.481983 — biochemistry — Posted on 2022-02-27

175 Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis

Astre, G.; Atlan, T.; Goshtchevsky, U.; Shapira, K.; Oron-Gottesman, A.; Levy, T.; Velan, A.; Smirnov, M.; Deelen, J.; Levanon, E. Y.; Harel, I.

10.1101/2022.01.10.475524 — genetics — Posted on 2022-02-27

176 A Deep Survival EWAS approach estimating risk profile based on pre-diagnostic DNA methylation: an application to Breast Cancer time to diagnosis

Massi, M. C.; Dominoni, L.; Ieva, F.; Fiorito, G.

10.1101/2022.02.25.481911 — genomics — Posted on 2022-02-27

177 Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors

Feng, S.; Rastogi, C.; Loker, R. E.; Glassford, W. J.; Rube, H. T.; Bussemaker, H. J.; Mann, R. S.

10.1101/2022.02.26.482133 — molecular biology — Posted on 2022-02-27

178 Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

10.1101/2022.02.25.481980 — neuroscience — Posted on 2022-02-27

179 Constructive Connectomics: how neuronal axons get from here to there using gene-expression maps derived from their family trees

Kerstjens, S.; Michel, G.; Douglas, R. J.

10.1101/2022.02.26.482112 — neuroscience — Posted on 2022-02-27

180 Sound-evoked responses of distinct neuron classes from the tail of the striatum

Nardoci, M. B.; Lakunina, A. A.; Pedregon, J. C.; Henderling, D. C.; Jaramillo, S.

10.1101/2022.02.26.482132 — neuroscience — Posted on 2022-02-27

181 Tango for Two: Modeling Synchronization and Social Interaction in Turn-Taking

Begel, V.; Demos, A. P.; Wang, M.; Palmer, C.

10.1101/2022.02.24.481865 — neuroscience — Posted on 2022-02-27

182 Reduced D-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia

Park, D. K.; Petshow, S.; Anisimova, M.; Barragan, E. V.; Gray, J. A.; Stein, I. S.; Zito, K.

10.1101/2021.03.04.434016 — neuroscience — Posted on 2022-02-27

183 Influence network model uncovers new relations between biological processes and mutational signatures

Amgalan, B.; Wojtowicz, D.; Kim, Y.-A.; Przytycka, T. M.

10.1101/2021.11.16.468828 — systems biology — Posted on 2022-02-26

184 Hypoconnectivity between anterior insula and amygdala in neonates with familial history of autism

Scheinost, D.; Chang, J.; Lacadie, C.; Brennan-Wydra, E.; Foster, R.; Boxberger, A.; Macari, S.; Vernetti, A.; Constable, R. T.; Ment, L. R.; Chawarska, K.

10.1101/2022.02.24.481850 — neuroscience — Posted on 2022-02-27

185 Molecular modeling predicts novel antibody escape mutations in respiratory syncytial virus fusion glycoprotein

Beach, S. S.; Hull, M.; Ytreberg, F. M.; Patel, J. S.; Miura, T. A.

10.1101/2022.02.25.482063 — microbiology — Posted on 2022-02-26

186 Zika virus induces mitotic catastrophe in human neural progenitors by triggering unscheduled mitotic entry in the presence of DNA damage while functionally depleting nuclear PNKP

Rychlowska, M.; Agyapong, A.; Weinfeld, M.; Schang, L. M.

10.1101/2021.08.27.458001 — microbiology — Posted on 2022-02-26

187 Reconsider phase reconstruction in signals with dynamic periodicity from the modern signal processing perspective

Alian, A.; Lo, Y.-L.; Shelley, K.; Wu, H.-T.

10.1101/2020.09.29.310417 — physiology — Posted on 2022-02-26

188 Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig: preliminary report

Mondal, P.; Patel, N.; Bailey, K.; Lazenby, A. J.; Carlson, M. A.

10.1101/2020.05.29.123547 — cancer biology — Posted on 2022-02-26

189 A Tunable, Simplified Model for Biological Latch Mediated Spring Actuated Systems

Cook, A.; Pandhigunta, K.; Acevedo, M. A.; Walker, A.; Didcock, R. L.; Castro, J. T.; O'Neill, D.; Acharya, R.; Bhamla, M. S.; Anderson, P. S. L.; Ilton, M.

10.1101/2020.12.02.408740 — biophysics — Posted on 2022-02-26

190 Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain

Rahighi, S.; Iyer, M.; Oveisi, H.; Nasser, S.; Duong, V.

10.1101/2022.02.25.482043 — biochemistry — Posted on 2022-02-26

191 Genomic and phenotypic comparisons reveal distinct variants of Wolbachia strain wAlbB

Martinez, J.; Ross, P. A.; Gu, X.; Ant, T.; Murdochy, S.; Tong, L.; da Silva Filipe, A.; Hoffmann, A. A.; Sinkins, S. P.

10.1101/2022.02.25.482065 — genomics — Posted on 2022-02-26

192 Follow-up investigation and detailed mutational characterization of the SARS-CoV-2 Omicron variant lineages (BA.1, BA.2, BA.3 and BA.1.1)

Abbas, Q.; Kusakin, A. V.; Sharrouf, K.; Jyakhwo, S.; Komissarov, A. S.

10.1101/2022.02.25.481941 — genetics — Posted on 2022-02-26

193 Genomic basis and phenotypic manifestation of (non-)parallel serpentine adaptation in Arabidopsis arenosa

Konecna, V.; Sustr, M.; Pozarova, D.; Certner, M.; Krejcova, A.; Tylova, E.; Kolar, F.

10.1101/2022.02.26.482078 — evolutionary biology — Posted on 2022-02-26

194 Proteomic analysis of human milk reveals nutritional and immune benefits in the colostrum from mothers with COVID-19

Guo, J.; Tan, M.; Zhu, J.; Tian, Y.; Liu, H.; Luo, F.; Wang, J.; Huang, Y.; Zhang, Y.; Yang, Y.; Wang, G.

10.1101/2022.02.25.481966 — molecular biology — Posted on 2022-02-26

195 Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

Morton, J. T.; Jin, D.-m.; Mills, R.; Shao, Y.; Rahman, G.; Harold-Berding, K.; Needham, B. D.; Zurita, M. F.; David, M.; Averina, O.; Kovtun, A.; Noto, A.; Mussap, M.; Wang, M.; Frank, D.; Li, E.; Zhou, W.; Fanos, V.; Danilenko, V.; Wall, D. P.; Cardenas, P. A.; Baldeon, M.; xavier, r. j.; Mazmanian, S.; Knight, R.; Gilbert, J.; Donovan, S.; Lawley, T.; Carpenter, B.; Bonneau, R.; Taroncher-Oldenburg, G.

10.1101/2022.02.25.482050 — microbiology — Posted on 2022-02-26

196 Protection of Hamsters Challenged with SARS-CoV-2 after Two Doses of MVC-COV1901 Vaccine Followed by a Single Intranasal Booster with Nanoemulsion Adjuvanted S-2P Vaccine

Lin, Y.-J.; Lin, M.-Y.; Chuang, Y.-S.; Liu, L. T. C.; Kuo, T.-Y.; Chen, C.; Ganesan, S.; Fattom, A.; Bitko, V.; Lien, C.-E.

10.1101/2022.02.24.481901 — immunology — Posted on 2022-02-26

197 The GENOMES UNCOUPLED1 protein has an ancient, highly conserved role in chloroplast gene expression but not in retrograde signalling

Honkanen, S.; Small, I.

10.1101/2022.02.25.481377 — plant biology — Posted on 2022-02-26

198 Nicotinamide Riboside alleviates exercise intolerance in ANT1-deficient mice.

Schaefer, P. M.; Huang, J.; Butic, A.; Perry, C. E.; Yardeni, T.; Tan, W.; Morrow, R.; Baur, J. A.; Wallace, D. C.

10.1101/2022.02.25.481689 — physiology — Posted on 2022-02-26

199 Development of a LAG-3 Immunohistochemistry Assay for Melanoma

Johnson, L.; McCune, B.; Locke, D.; Hedvat, C.; Wojcik, J. B.; Schroyer, C.; Yan, J.; Johnson, K.; Sanders-Cliette, A.; Samala, S.; Dillon, L. M.; Anderson, S.; Shuster, J.

10.1101/2022.02.25.481964 — pathology — Posted on 2022-02-26

200 TGF-beta1 induced S100 family protein expression is associated with epithelial to mesenchymal transition states and poor survival in pancreatic cancer

Low, R. R. J.; Fung, K. Y.; Gao, H.; Preaudet, A.; Dagley, L. F.; Yousef, J.; Lee, B.; Larsen, R. H.; Kershaw, N. J.; Burgess, A. W.; Gibbs, P.; Hollande, F.; Griffin, M. D. W.; Grimmond, S. M.; Putoczki, T. L.

10.1101/2022.02.25.481888 — cancer biology — Posted on 2022-02-26

201 PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state.

Machado, C. M.; Skubal, M.; Haedicke, K.; Pittela, F. S.; Stater, E. P.; Larney, B. M.; Silva, T. L. A. O.; Costa, E. T.; Masotti, C.; Otake, A. H.; Andrade, L. N. S.; Junqueira, M. S.; Hsu, H.-T.; Das, S.; Pratt, E. C.; Romin, Y.; Fan, N.; Todorova, K. M.; Pomper, M.; Grimm, J.

10.1101/2022.02.25.482024 — cancer biology — Posted on 2022-02-26

202 Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level

Sefer, A.; Kallis, E.; Eilert, T.; Roecker, C.; Neuhaus, D.; Eustermann, S.; Michaelis, J.

10.1101/2022.02.26.482089 — biophysics — Posted on 2022-02-26

203 Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

Muthusamy, A. K.; Kim, C. H.; Virgil, S. C.; Knox, H. J.; Marvin, J. S.; Nichols, A. L.; Cohen, B. N.; Dougherty, D. A.; Looger, L. L.; Lester, H. A.

10.1101/2022.02.24.481226 — bioengineering — Posted on 2022-02-26

204 Distinct chromosomal niches in the genome of S. cerevisiae provide the background for genomic innovation and shape the fate of gene duplicates

Stavropoulou, A.; Tassios, E.; Kalyva, M.; Georgoulopoulos, M.; Vakirlis, N.; Iliopoulos, I.; Nikolaou, C.

10.1101/2022.02.26.482092 — genomics — Posted on 2022-02-26

205 ProbeTools: Designing hybridization probes for targeted genomic sequencing of diverse and hypervariable viral taxa

Kuchinski, K. S.; Duan, J.; Himsworth, C.; Hsiao, W.; Prystajecky, N. A.

10.1101/2022.02.24.481870 — genomics — Posted on 2022-02-26

206 Infection by a eukaryotic gut parasite in wild Daphnia sp. associates with a distinct bacterial community

Rajarajan, A.; Wolinska, J.; Walser, J.-C.; Maeder, M.; Spaak, P.

10.1101/2022.02.25.481906 — ecology — Posted on 2022-02-26

207 Zebrafish her3 knockout impacts developmental and cancer-related gene signatures

Kent, M. R.; Calderon, D.; Silvius, K. M.; LaVigne, C. A.; Cannon, M. V.; Kendall, G. C.

10.1101/2022.02.25.482038 — developmental biology — Posted on 2022-02-26

208 Discovery of a novel coronavirus in Swedish bank voles (Myodes glareolus)

Wasberg, A.; Raghwani, J.; Li, J.; Pettersson, J. H.- O.; Lindahl, J.; Lundkvist, A.; Ling, J.

10.1101/2022.02.24.481848 — microbiology — Posted on 2022-02-26

209 Adenosine A2A Receptor (A2AR) agonists improve survival in K28-hACE2 mice following SARS CoV-2 infection

Mann, B. J.; Chhabra, P.; Ma, M.; Brovero, S. G.; Jones, M. K.; Linden, J. M.; Brayman, K. L.

10.1101/2022.02.25.481997 — microbiology — Posted on 2022-02-26

210 A structural dynamic explanation for observed escape of SARS-CoV-2 BA.2 variant mutation S371L/F

Miller, N. L.; Clark, T.; Raman, R.; Sasisekharan, R.

10.1101/2022.02.25.481957 — microbiology — Posted on 2022-02-26

211 DLK-dependent biphasic reactivation of herpes simplex virus latency established in the absence of antivirals

Dochnal, S. A.; Merchant, H.; Schinlever, A.; Babnis, A.; Depledge, D. P.; Wilson, A.; Cliffe, A. R.

10.1101/2022.02.25.482019 — microbiology — Posted on 2022-02-26

212 Transcriptomic landscapes of SARS-CoV-2-infected and bystander lung cells reveal a selective upregulation of NF-κB-dependent coding and non-coding proviral transcripts

Szachnowski, U.; Bhargava, A.; Chazal, M.; Foretek, D.; Aicher, S.-M.; Pipoli da Fonseca, J.; Jeannin, P.; Beauclair, G.; Monot, M.; Morillon, A.; Jouvenet, N.

10.1101/2022.02.25.481978 — microbiology — Posted on 2022-02-26

213 Early events in reovirus infection influence induction of innate immune response

Abad, A. T.; Danthi, P.

10.1101/2022.02.25.482062 — microbiology — Posted on 2022-02-26

214 Global distribution and diversity of prevalent sewage water plasmidomes

Teudt, F.; Otani, S.; Aarestrup, F. M.

10.1101/2022.02.25.482059 — microbiology — Posted on 2022-02-26

215 Conservation and evolution of the sporulation gene set in diverse members of the Firmicutes

Galperin, M. Y.; Yutin, N.; Wolf, Y. I.; Vera Alvarez, R.; Koonin, E. V.

10.1101/2022.02.25.481979 — microbiology — Posted on 2022-02-26

216 Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

Starr, T. N.; Greaney, A. J.; Hannon, W. W.; Loes, A. N.; Hauser, K.; Dillen, J. R.; Ferri, E.; Ghez Farrell, A.; Dadonaite, B.; McCallum, M.; Matreyek, K. A.; Corti, D.; Veesler, D.; Snell, G.; Bloom, J. D.

10.1101/2022.02.24.481899 — microbiology — Posted on 2022-02-26

217 IgG1 responses following SARS-CoV-2 infection are polyclonal and highly personalized, whereby each donor and each clone displays a distinct pattern of cross-reactivity against SARS-CoV-2 variants

van Rijswijck, D. M. H.; Bondt, A.; Hoek, M.; van der Straten, K.; Caniels, T. G.; Poniman, M.; Eggink, D.; Reusken, C. B. E. M.; de Bree, G. J.; Sanders, R. W.; van Gils, M.; Heck, A. J. R.

10.1101/2022.02.24.481778 — immunology — Posted on 2022-02-26

218 The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

Thakore, P. I.; Schnell, A.; Zhao, M.; Huang, L.; Hou, Y.; Christian, E.; Zaghouani, S.; Wang, C.; Singh, V.; Ma, S.; Sankar, V.; Notarbartolo, S.; Buenrostro, J. D.; Sallusto, F.; Patsopoulos, N. A.; Rozenblatt-Rosen, O.; Kuchroo, V. K.; Regev, A.

10.1101/2022.02.26.482041 — immunology — Posted on 2022-02-26

219 Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection

Kabat, A. M.; Hackl, A.; Sanin, D. E.; Zeis, P.; Grzes, K. M.; Baixauli, F.; Kyle, R.; Caputa, G.; Edwards-Hicks, J.; Villa, M.; Rana, N.; Curtis, J. D.; Castoldi, A.; Cupovic, J.; Dreesen, L.; Sibilia, M.; Pospisilik, J. A.; Urban, J. F.; Grün, D.; Pearce, E. L.; Pearce, E. J.

10.1101/2022.02.24.481701 — immunology — Posted on 2022-02-26

220 Distinct execution modes of a biochemical necroptosis model explain cell type-specific responses and variability to cell-death cues

Ildefonso, G. V.; Oliver Metzig, M.; Hoffmann, A.; Harris, L. A.; Lopez, C. F.

10.1101/2022.02.25.481705 — systems biology — Posted on 2022-02-26

221 Cryo-EM structure of the Rhodobaca bogoriensis RC-LH1-PufX dimeric complex at 2.9 angstrom

Semchonok, D. A.; Siponen, M. I.; Toeting, C.; Charras, Q.; Kyrilis, F. L.; Sadian, Y.; Jungas, C.; Kastritis, P. L.

10.1101/2022.02.25.481955 — biophysics — Posted on 2022-02-26

222 Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

Lyapina, E.; Marin, E.; Gusach, A.; Orekhov, P.; Gerasimov, A.; Luginina, A.; Vakhrameev, D.; Ergasheva, M.; Kovaleva, M.; Khusainov, G.; Khorn, P.; Shevtsov, M.; Kovalev, K.; Okhrimenko, I.; Popov, P.; Hu, H.; Weierstall, U.; Liu, W.; Cho, Y.; Gushchin, I.; Rogachev, A.; Bourenkov, G.; Park, S.; Park, G.; Hyun, H. J.; Park, J.; Gordeliy, V.; Borshchevskiy, V.; Mishin, A.; Cherezov, V.

10.1101/2022.02.25.480536 — biophysics — Posted on 2022-02-26

223 A general theory of specific binding: insights from a genetic, mechano-chemical protein model

McBride, J. M.; Eckmann, J.-P.; Tlusty, T.

10.1101/2022.02.26.482086 — biochemistry — Posted on 2022-02-26

224 Natural Variation Meets Synthetic Biology: Promiscuous Trichome Expressed Acyltransferases from Nicotiana acuminata

Schenck, C.; Anthony, T. M.; Jacobs, M. L.; Jones, A. D.; Last, R. L.

10.1101/2022.02.25.482030 — biochemistry — Posted on 2022-02-26

225 The structure of Vibrio cholerae FeoC reveals conservation of the helix-turn-helix motif but not the cluster-binding domain

Brown, J. B.; Lee, M. A.; Smith, A. T.

10.1101/2022.02.26.482101 — biochemistry — Posted on 2022-02-26

226 Dictionary learning for integrative, multimodal, and scalable single-cell analysis

Hao, Y.; Stuart, T.; Kowalski, M.; Choudhary, S.; Hoffman, P.; Hartman, A.; Srivastava, A.; Molla, G.; Madad, S.; Fernandez-Granda, C.; Satija, R.

10.1101/2022.02.24.481684 — genomics — Posted on 2022-02-26

227 Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression

Bishop, C. R.; Dumenil, T.; Rawle, D. J.; Le, T.; Yan, K.; Tang, B.; Hartel, G.; Suhrbier, A.

10.1101/2022.02.24.481866 — molecular biology — Posted on 2022-02-26

228 Long-Term Culture of Patient-Derived Cardiac Organoids Recapitulated Duchenne Muscular Dystrophy Cardiomyopathy and Disease Progression

Marini, V.; Marino, F.; Aliberti, F.; Giarratana, N.; Pozzo, E.; Duelen, R.; Cortes-Calabuig, A.; Larovere, R.; Vervliet, T.; Torella, D.; Bultynck, G.; Sampaolesi, M.; Chai, Y. C.

10.1101/2022.02.25.481935 — cell biology — Posted on 2022-02-26

229 Human cytomegalovirus vMIA inhibits MAVS oligomerization at peroxisomes in an MFF-dependent manner

Ferreira, A. R.; Gouveia, A.; Magalhaes, A. C.; Valenca, I.; Marques, M.; Kagan, J. C.; Ribeiro, D.

10.1101/2022.02.25.481859 — cell biology — Posted on 2022-02-26

230 Skeletal muscle-derived extracellular vesicles are altered with chronic contractile activity

Obi, P. O.; Seif, S.; Bydak, B.; Pierdona, T. M.; Turner-Brannen, E.; West, A. R.; Labouta, H. I.; Gordon, J.; Saleem, A.

10.1101/2022.02.25.481852 — cell biology — Posted on 2022-02-26

231 Blood cells communicate remotely via an NMDA receptor-mediated glutamatergic chain-reaction

Kopach, O.; Sylantyev, S.; Bard, L.; Michaluk, P.; Gutierrez del Arroyo, A.; Ackland, G. L.; Rusakov, D. A.

10.1101/2022.02.25.482046 — cell biology — Posted on 2022-02-26

232 IRE1 RNase controls CD95-mediated cell death

Pelizzari-Raymundo, D.; Le Gallo, M.; Pineau, R.; Papaioannou, A.; Martin, S.; Avril, T.; chevet, e.; Lafont, E.

10.1101/2022.02.25.481813 — cell biology — Posted on 2022-02-26

233 Dissociable default-mode subnetworks subserve childhood attention and cognitive flexibility: evidence from deep learning and stereotaxic electroencephalography

Warsi, N.; Wong, S. M.; Germann, J.; Boutet, A.; Arski, O.; Anderson, R.; Erdman, L.; Yan, H.; Suresh, H.; Venetucci Gouveia, F.; Loh, A.; Elias, G.; Kerr, E.; Smith, M. L.; Ochi, A.; Otsubo, H.; Sharma, R.; Jain, P.; Donner, E.; Lozano, A. M.; Snead, O. C.; Ibrahim, G.

10.1101/2022.02.25.481973 — neuroscience — Posted on 2022-02-26

234 Interaction of human keratinocytes and nerve fiber terminals at the neuro-cutaneous unit

Erbacher, C.; Britz, S.; Dinkel, P.; Klein, T.; Sauer, M.; Stigloher, C.; Üceyler, N.

10.1101/2022.02.23.481592 — neuroscience — Posted on 2022-02-26

235 Transcranial photobiomodulation enhances visual working memory capacity in humans

Zhao, C.; Li, D.; Kong, Y.; Liu, H.; Hu, Y.; Niu, H.; Jensen, O.; Li, X.; Liu, H.; Song, Y.

10.1101/2022.02.24.481703 — neuroscience — Posted on 2022-02-26

236 iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation

Tristan Noguero, A.; Fernandez-Carasa, I.; Calatayud, C.; Bermejo-Casadesus, C.; Campa, L.; Artigas, F.; Domingo-Jimenez, R.; Ibanez, S.; Pineda, M.; Artuch, R.; Raya, A.; Garcia Cazorla, A.; Consiglio, A.

10.1101/2022.02.24.481741 — neuroscience — Posted on 2022-02-26

237 FtsH Protease Inactivation Allows Accumulation of Aberrant Photosystem II in a Chlamydomonas Rubredoxin Mutant

Calderon, R. H.; de Vitry, C.; Wollman, F.-A.; Niyogi, K. K.

10.1101/2022.02.24.481860 — plant biology — Posted on 2022-02-26

238 An inosine triphosphate pyrophosphatase safeguards nucleic acids from aberrant purine nucleotides and prevents a constitutive salicylic acid response

Straube, H.; Straube, J.; Rinne, J.; Niehaus, M.; Rose, H.; Witte, C.-P.; Herde, M.

10.1101/2022.02.24.481826 — plant biology — Posted on 2022-02-26

239 ATR kinase inhibition induces thymineless death in proliferating CD8+ T cells

Sugitani, N.; Vendetti, F. P.; Cipriano, A. J.; Deppas, J. J.; Moiseeva, T. N.; Schamus-Haynes, S.; Wang, Y.; Palmer, D.; Osmanbeyoglu, H. U.; Bostwick, A.; Snyder, N. W.; Gong, Y.-N.; Aird, K. M.; Delgoffe, G. M.; Beumer, J. H.; Bakkenist, C. J.

10.1101/2022.02.24.481821 — cancer biology — Posted on 2022-02-26

240 A novel missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish

Ellis, J. L.; Evason, K. J.; Zhang, C.; Fourman, M. N.; Liu, J.; Ninov, N.; DELOUS, M.; Vanhollebeke, B.; Fiddes, I. T.; Otis, J. P.; Houvras, Y.; Farber, S. A.; Xu, X.; Lin, X.; Stainier, D. Y.; Yin, C.

10.1101/2022.02.24.481764 — developmental biology — Posted on 2022-02-26

241 Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole

Zhao, J.; Bui, M. T.; Ma, J.; Kuenzl, F.; De La Concepcion, J. C.; Chen, Y.; Petsangouraki, S.; Mohseni, A.; Garcia Leon, M.; Salas-Gomez, M.; Giannini, C.; Gwennogan, D.; Kobylinska, R.; Clavel, M.; Schellmann, S.; Jaillais, Y.; Friml, J.; Kang, B.-H.; Dagdas, Y.

10.1101/2022.02.26.482093 — plant biology — Posted on 2022-02-26

242 Development and optimization of a Barley stripe mosaic virus (BSMV)-mediated gene editing system to improve Fusarium head blight (FHB) resistance in wheat

Chen, H.; Su, Z.; Tian, B.; Liu, Y.; Pang, Y.; Kavetskyi, V.; Trick, H. N.; Bai, G.

10.1101/2022.02.25.481987 — plant biology — Posted on 2022-02-26

243 Molecular dynamics simulations of the Spike trimeric ectodomain of the SARS-CoV-2 Omicron variant: structural relationships with infectivity, evasion to immune system and transmissibility

Amorim, V. M. d. F.; de Souza, R. F.; Souza, A. S. d.; Guzzo, C. R.

10.1101/2022.02.14.480347 — biophysics — Posted on 2022-02-26

244 EagleImp-Web: A Fast and Secure Genotype Phasing and Imputation Web Service using Field-Programmable Gate Arrays

Wienbrandt, L.; Priess, C.; Kässens, J. C.; Franke, A.; Uhing, F.; Ellinghaus, D.

10.1101/2022.02.24.481790 — bioinformatics — Posted on 2022-02-26

245 FIT-GWA: A new method for the genetic analysis of small gene effects, high precision in phenotype measurements and small sample sizes.

Rauch, C.; Blott, S.; Kyratzi, P.; Bray, S.; Wattis, J.

10.1101/2022.02.25.479563 — genetics — Posted on 2022-02-26

246 Expanding the pulse-reserve paradigm to microorganisms on the basis of differential reserve management strategies

Garcia-Pichel, F.; Sala, O. E.

10.1101/2022.02.24.481838 — ecology — Posted on 2022-02-26

247 Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

Rothenberger, S.; Hurdiss, D. L.; Walser, M.; Malvezzi, F.; Mayor, J.; Ryter, S.; Moreno, H.; Liechti, N.; Bosshart, A.; Iss, C.; Calabro, V.; Cornelius, A.; Hospodarsch, T.; Neculcea, A.; Looser, T.; Schlegel, A.; Fontaine, S.; Villemagne, D.; Paladino, M.; Kaufmann, Y.; Schaible, D.; Schlegel, I.; Schiegg, D.; Zitt, C.; Sigrist, G.; Straumann, M.; Sacarcelik, F.; Wolter, J.; Comby, M.; Adler, J. M.; Eschke, K.; Nascimento, M.; Abdelgawad, A.; Gruber, A. D.; Bushe, J.; Kershaw, O.; Lyoo, H.; Wang, C.; Li, W.; Drulyte, I.; Du, W.; Binz, K.; Herrup, R.; Lusvarghi, S.; Neerukonda, S. N.; Vassell

10.1101/2021.02.03.429164 — immunology — Posted on 2022-02-26

248 Monkeys exhibit human-like gaze biases in economic decisions

Lupkin, S. M.; McGinty, V. B.

10.1101/2022.02.24.481847 — neuroscience — Posted on 2022-02-26

249 Brevican, Neurocan, Tenascin-C and Tenascin-R Act as Important Regulators of the Interplay between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons and Otx2

Mueller-Buehl, C.; Reinhard, J.; Roll, L.; Bader, V.; Winklhofer, K. F.; Faissner, A.

10.1101/2022.02.24.481837 — neuroscience — Posted on 2022-02-26

250 Teosinte mexicana introgression modulates phosphatidylcholine levels and maize flowering time

Barnes, A. C.; Rodriguez-Zapata, F.; Blocher-Juarez, K. A.; Gates, D. J.; Janzen, G. M.; Kur, A.; Wang, L.; Jensen, S. E.; Estevez-Palmas, J. M. M.; Crow, T. M.; Kavi, H. S.; Pil, H. D.; Stokes, R. L.; Knizner, K. T.; Aguilar-Rangel, M. R.; Demesa-Arevalo, E.; Skopelitis, T.; Perez-Limon, S.; Stutts, W. L.; Thompson, P.; Chiu, Y.-C.; Jackson, D.; Muddiman, D. C.; Fiehn, O.; Runcie, D.; Buckler, E. S.; Ross-Ibarra, J.; Hufford, M. B.; Sawers, R. J.; Rellan-Alvarez, R.

10.1101/2021.01.25.426574 — plant biology — Posted on 2022-02-26

251 Convergent evolution of multiple mutations improves the viral fitness of SARS-CoV-2 variants by balancing positive and negative selection

Upadhyay, V.; Patrick, C.; Lucas, A.; Mallela, K.

10.1101/2021.12.23.474050 — biophysics — Posted on 2022-02-26

252 Stochastic variational variable selection for high-dimensional microbiome data

Dang, T.; Kumaishi, K.; Usui, E.; Kobori, S.; Sato, T.; Ichihashi, Y.; Yusuke, T.; Yamasaki, Y.; Tsujimoto, H.; Iwata, H.

10.1101/2021.10.04.462986 — bioinformatics — Posted on 2022-02-26

253 One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria

Petragnano, F.; Fasciani, I.; Wang, Z.; Edwards, R.; Telugu, N.; Pietrantoni, I.; Zauber, H.; Rossi, M.; Zabel, U.; Grieben, M.; Terzenidou, M. E.; Di Gregorio, J.; Pellegrini, C.; Santini, S.; Taddei, A. R.; Poehl, B.; Aringhieri, S.; Carli, M.; Aloisi, G.; Marampon, F.; Roman, A.; Diecke, S.; Flati, V.; Giorgi, F.; Tobin, A. B.; Scarselli, M.; Tokatlidis, K.; Amicarelli, F.; Lohse, M. J.; Maggio, R.; Annibale, P.

10.1101/2021.04.13.438299 — cell biology — Posted on 2022-02-26

254 Stability And Shelf-Life Of Plasma Bubbling Treated Cow Milk

Dash, S.; Rangarajan, J.

10.1101/2022.02.18.480824 — microbiology — Posted on 2022-02-26

255 Early tetrapod diversification under neutral theory

Dunne, E. M.; Thompson, S. E. D.; Butler, R. J.; Rosindell, J.; Close, R. C.

10.1101/2022.02.08.476633 — evolutionary biology — Posted on 2022-02-26

256 Non-motile subpopulations of Pseudomonas aeruginosa repress flagellar motility in motile cells through a type IV pili- and Pel-dependent mechanism

Lewis, K. A.; Vermilyea, D. M.; Webster, S. S.; Geiger, C. J.; de Anda, J.; Wong, G.; O'Toole, G. A.; Hogan, D. A.

10.1101/2021.10.21.465385 — microbiology — Posted on 2022-02-26

257 The unfolded protein response triggers the immune deficiency pathway in ticks

Sidak-Loftis, L. C.; Rosche, K. L.; Pence, N.; Ujczo, J. K.; Hurtado, J.; Fisk, E. A.; Goodman, A. G.; Noh, S. M.; Peters, J. W.; Shaw, D. K.

10.1101/2021.08.31.458430 — immunology — Posted on 2022-02-26

258 Host Chitinase 3-like-1 is a Universal Therapeutic Target for SARS-CoV-2 Viral Variants in COVID 19

Kamle, S.; Ma, B.; Lee, C. M.; Schor, G.; Zhou, Y.; Lee, C. G.; Elias, J. A.

10.1101/2022.01.21.477274 — immunology — Posted on 2022-02-26

259 The inhibitory effect of EGCG-AgNP-lysozyme bioconjugates on biofilm formation

Meesaragandla, B.; Hayet, S.; Fine, T.; Janke, U.; chai, l.; Delcea, M.

10.1101/2022.02.23.481602 — biophysics — Posted on 2022-02-26

260 Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts

Mostert, D.; Groenen, B.; Klouda, L.; Kurniawan, N. A.; Bouten, C.

10.1101/2021.02.16.431369 — biophysics — Posted on 2022-02-26

261 A Combined Human Gastruloid Model of Cardiogenesis and Neurogenesis

Olmsted, Z. T.; Paluh, J. L.

10.1101/2022.02.25.481991 — developmental biology — Posted on 2022-02-25

262 Bioactive constituents of Verbena officinalis regulate killing efficiency of primary human natural killer cells by accelerating killing processes

Shao, R.; Zhou, X.; Zhao, R.; Yanamandra, A. K.; Xing, Z.; Dai, X.; Zhang, H.; Wang, Y.; Wang, Y.; Qu, B.

10.1101/2021.10.22.465498 — immunology — Posted on 2022-02-25

263 Human neutrophil development and functionality are enabled in a humanized mouse model

Zheng, Y.; Sefik, E.; Astle, J.; Solis, A. G.; Oz, H. H.; Jackson, R.; Bruscia, E. M.; Halene, S.; Shan, L.; Flavell, R. A.

10.1101/2022.02.25.481352 — immunology — Posted on 2022-02-25

264 A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states

Draeger, N. M.; Sattler, S. M.; Huang, C. T.-L.; Teter, O. M.; Leng, K.; Hashemi, S. H.; Hong, J.; Aviles, G.; Clelland, C. D.; Zhan, L.; Udeochu, J. C.; Kodama, L.; Singleton, A. B.; Nalls, M. A.; Ichida, J.; Ward, M. E.; Faghri, F.; Gan, L.; Kampmann, M.

10.1101/2021.06.16.448639 — neuroscience — Posted on 2022-02-25

265 Value, confidence, deliberation: a functional partition of the medial prefrontal cortex demonstrated across rating and choice tasks

Clairis, N.; Pessiglione, M.

10.1101/2020.09.17.301291 — neuroscience — Posted on 2022-02-25

Cometa, A.; D'Orio, P.; Revay, M.; Bottoni, F.; Repetto, C.; Lo Russo, G.; Cappa, S. F.; Moro, A.; Micera, S.; Artoni, F.

10.1101/2022.02.25.481939 — neuroscience — Posted on 2022-02-25

267 Cortical compensation for afferent loss in older adults: Associations with GABA and speech recognition in noise

Harris, K. C.; Balken, B.; Dias, J. W.; McClaskey, C. M.; Rumschlag, J.; Prisciandaro, J.; Dubno, J.

10.1101/2022.02.24.481839 — neuroscience — Posted on 2022-02-25

268 Interactions and information: Exploring task allocation in ant colonies using network analysis

Swain, A.; Williams, S. D.; Di Felice, L. J.; Hobson, E. A.

10.1101/2021.03.29.437501 — animal behavior and cognition — Posted on 2022-02-25

269 A tissue specific atlas of gene promoter DNA methylation variability and the clinical value of its assessment

Miller, R. H.; Pollard, C. A.; Brogaard, K. R.; Olson, A. C.; Lipshultz, L. I.; Johnstone, E. B.; Ibrahim, Y. O.; Hotaling, J. M.; Schisterman, E. F.; Mumford, S. L.; Aston, K. I.; Jenkins, T. G.

10.1101/2022.02.04.479170 — genomics — Posted on 2022-02-25

270 Practical application of indicators for genetic diversity in CBD post-2020 Global Biodiversity Framework implementation

Thurfjell, H.; Laikre, L.; Ekblom, R.; Hoban, S.; Sjogren-Gulve, P.

10.1101/2022.02.18.481087 — genetics — Posted on 2022-02-25

271 No leeway to enhance carbon sequestration and stock capacity via changes to forest management

Dalmonech, D.; Marano, G.; Amthor, J.; Cescatti, A.; Lindner, M.; Trotta, C.; Collalti, A.

10.1101/2022.02.10.479900 — ecology — Posted on 2022-02-25

272 E-Cadherin mediated AMIS localisation

Liang, X.; Weberling, A.; Hii, C. Y.; Zernicka-Goetz, M.; Buckley, C. E.

10.1101/2021.11.30.470571 — developmental biology — Posted on 2022-02-25

273 Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth

Seel, A.; Padovani, F.; Finster, A.; Mayer, M.; Bureik, D.; Osman, C.; Klecker, T.; Schmoller, K. M.

10.1101/2021.12.03.471050 — cell biology — Posted on 2022-02-25

274 A novel Fiji/ImageJ plugin for the rapid analysis of blebbing cells

Vosatka, K. W.; Lavenus, S. B.; Logue, J. S.

10.1101/2021.06.04.447112 — cell biology — Posted on 2022-02-25

275 Implicit Laplacian of Enhanced Edge: An Unguided Algorithm for Accurate and Automated Quantitative Analysis of Cytoskeletal Images

Li, P.; Zhang, Z.; Tong, Y.; Foda, B. M.; Day, B.

10.1101/2021.05.11.442512 — cell biology — Posted on 2022-02-25

276 Antimalarials in mosquitoes overcome Anopheles and Plasmodium resistance to malaria control strategies

Paton, D. G.; Probst, A. S.; Ma, E.; Adams, K. L.; Shaw, W. R.; Singh, N.; Bopp, S.; Volkman, S. K.; Hien, D. F. S.; Pare, P.; Yerbanga, S. R.; Diabate, A.; Dabire, R. K.; Lefevre, T.; Wirth, D.; Catteruccia, F.

10.1101/2021.03.12.435188 — microbiology — Posted on 2022-02-25

277 The ankyrin repeat protein RARP-1 is a periplasmic factor that supports Rickettsia parkeri growth and host cell invasion

Sanderlin, A. G.; Hanna, R. E.; Lamason, R. L.

10.1101/2022.02.23.481736 — microbiology — Posted on 2022-02-25

278 MHC-matched allogeneic bone marrow transplant fails to eliminate SHIV-infected cells from ART-suppressed Mauritian cynomolgus macaques

Weinfurter, J. T.; D'Souza, S. S.; Matschke, L. M.; Bennett, S.; Kelnhofer-Millevolte, L. E.; Suknuntha, K.; Kumar, A.; Coonen, J.; Capitini, C. M.; Hematti, P.; Golos, T. G.; Slukvin, I. I.; Reynolds, M. R.

10.1101/2021.04.16.440168 — immunology — Posted on 2022-02-25

279 Cyclic, condition-independent activity in primary motor cortex predicts corrective movement behavior

Rouse, A. G.; Schieber, M. H.; Sarma, S. V.

10.1101/453746 — neuroscience — Posted on 2022-02-25

280 Cerebral laterality for writing in right- and left-handers: A functional transcranial Doppler ultrasound study

Papadatou-Pastou, M.; Sampanis, P.; Koumzis, I.; Stefanopoulou, S.; Sousani, D.; Tsigkou, A.; Badcock, N. A.

10.1101/2020.07.14.203588 — neuroscience — Posted on 2022-02-25

281 The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

Dard, R. F.; Leprince, E.; Denis, J.; Suchkov, D.; RAO-BALAPPA, S.; Boyce, R.; Lopez, C.; Giorgi-Kurz, M.; Szwagier, T.; Dumont, T.; Rouault, H.; Minlebaev, M.; Baude, A.; Cossart, R.; Picardo, M. A.

10.1101/2021.06.08.447542 — neuroscience — Posted on 2022-02-25

282 Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment

Baek, M. L.; Lee, J.; Pendleton, K. E.; Berner, M. J.; Goff, E. B.; Tan, L.; Martinez, S. A.; Wang, T.; Meyer, M. D.; Lim, B.; Barrish, J. P.; Porter, W.; Lorenzi, P. L.; Echeverria, G. V.

10.1101/2022.02.25.481996 — cancer biology — Posted on 2022-02-25

283 NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

Narang, S.; Evensen, N.; Saliba, J.; Pierro, J.; Loh, M. L.; Brown, P. A.; Mulder, H.; Shao, Y.; Easton, J.; Ma, X.; Tsirigos, A.; Carroll, W. L.

10.1101/2022.02.24.481835 — cancer biology — Posted on 2022-02-25

284 Role of Delta-Notch signalling molecules on cell-cell adhesion in determining heterogeneous chemical and cell morphological patterning

Bajpai, S.; Chelakkot, R.; Prabhakar, R.; Inamdar, M. M.

10.1101/2022.02.25.481961 — biophysics — Posted on 2022-02-25

285 Effect of Ionic Strength on the Assembly of Simian Vacuolating Virus Capsid Protein Around Poly(Styrene Sulfonate)

Asor, R.; Singaram, S. W.; Levi-Kalisman, Y.; Hagan, M. F.; Raviv, U.

10.1101/2022.02.25.481942 — biophysics — Posted on 2022-02-25

286 SKIOME Project: a curated collection of skin microbiome datasets enriched with study-related metadata

Agostinetto, G.; Bozzi, D.; Porro, D.; Casiraghi, M.; Labra, M.; Bruno, A.

10.1101/2021.08.17.456635 — bioinformatics — Posted on 2022-02-25

287 A Deep Survival EWAS approach estimating risk profile based on pre-diagnostic DNA methylation: an application to Breast Cancer time to diagnosis

Massi, M. C.; Dominoni, L.; Ieva, F.; Fiorito, G.

10.1101/2022.02.25.481911 — genomics — Posted on 2022-02-25

288 Horizontal gene transfer increases microbiome stability

Coyte, K. Z.; Stevenson, C.; Knight, C. G.; Harrison, E.; Hall, J. P. J.; Brockhurst, M. A.

10.1101/2022.02.25.481914 — evolutionary biology — Posted on 2022-02-25

289 Multiple hybridization events punctuate the evolutionary trajectory of Malassezia furfur

Theelen, B.; Mixao, V.; Ianiri, G.; Goh, J. P. Z.; Dijksterhuis, J.; Heitman, J.; Dawson, T. L.; Gabaldon, T.; Boekhout, T.

10.1101/2021.11.02.466935 — evolutionary biology — Posted on 2022-02-25

290 Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system

Ballesteros, A.; Yadav, M.; Cui, R.; Kurima, K.; Kachar, B.

10.1101/2022.02.25.482032 — cell biology — Posted on 2022-02-25

291 The BAF A12T mutation reduces BAF affinity to lamin A/C, preventing its recruitment to nuclear ruptures in Nestor Guillermo Progeria Syndrome cells.

Janssen, A. F. J.; Marcelot, A.; Breusegem, S. Y.; Legrand, P.; Zinn-Justin, S.; Larrieu, D.

10.1101/2022.02.25.481780 — cell biology — Posted on 2022-02-25

292 Comparative transcriptomics reveal highly conserved regional programs between porcine and human colonic enteric nervous system

Li, T.; Morselli, M.; Su, T.; Mulugeta, M.; Larauche, M.; Tache, Y.; Yuan, P.-Q.

10.1101/2022.02.24.480770 — molecular biology — Posted on 2022-02-25

293 Reduced polymerase pausing compensates for increased chromatin accessibility in the aging liver

Bozukova, M.; Grbavac, D.; Nikopoulou, C.; Tessarz, P.

10.1101/2022.02.25.481984 — molecular biology — Posted on 2022-02-25

294 Herpes Simplex Virus Reactivation Induced Ex Vivo Involves a DLK-Dependent but Histone Demethylase-Independent Wave of Lytic Gene Expression

Whitford, A. L.; Clinton, C. A.; Kennedy, E. B. L.; Dochnall, S. A.; Suzich, J. B.; Cliffe, A. R.

10.1101/2022.02.25.481951 — microbiology — Posted on 2022-02-25

295 Active site mutations in the bacterial actin homolog FtsA impair direct interactions with the divisome in Escherichia coli

Morrison, J. J.; Ferreira, C. N.; Siler, E. M.; Nelson, K.; Trebino, C. E.; Piraino, B.; Camberg, J. L.

10.1101/2022.02.25.482027 — microbiology — Posted on 2022-02-25

296 The Neisseria meningitidis iron acquisition protein HpuA moonlights as an adhesin and inhibits host cell migration

Shortt, G.; Ren, X.; Otto, B. M.; MacKichan, J. K.

10.1101/2022.02.25.481912 — microbiology — Posted on 2022-02-25

297 The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus

Goldmann, M.; Schmidt, F.; Cseresnyes, Z.; Orasch, T.; Jahreis, S.; Hartung, S.; Figge, M. T.; von Lilienfeld-Toal, M.; Heinekamp, T.; Brakhage, A. A.

10.1101/2022.02.25.481948 — microbiology — Posted on 2022-02-25

298 Rif-Correct, a software tool for bacterial mRNA half-life estimation

Aretakis, J. R.; Schrader, J. M.

10.1101/2022.02.25.481994 — microbiology — Posted on 2022-02-25

299 Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta

McMillen, C.; Boyles, D. A.; Kostadinov, S.; Hoehl, R. M.; Schwarz, M.; Albe, J.; Demers, M. J.; Hartman, A. L.

10.1101/2022.02.25.481831 — microbiology — Posted on 2022-02-25

300 Microbial Community Dynamics Provide Evidence for Hypoxia During a Coral Reef Mortality Event

Doyle, S. M.; Self, M. J.; Hayes, J.; Shamberger, K. E. F.; Correa, A. M. S.; Davies, S.; Santiago-Vazquez, L. Z.; Sylvan, J. B.

10.1101/2022.02.24.481904 — microbiology — Posted on 2022-02-25

301 T Cell Deficiency Precipitates Antibody Evasion and Emergence of Neurovirulent Polyomavirus

Lauver, M. D.; Ayers, K. N.; Carey, S. N.; Specht, C. S.; Abendroth, C. S.; Lukacher, A. E.

10.1101/2022.02.25.481945 — immunology — Posted on 2022-02-25

302 Generation of PRKN and PINK1-KO and double KO cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

Chen, C. X.- Q.; You, Z.; Abdian, N.; Sirois, J.; Shlaifer, I.; Tabatabaei, M.; Boivin, M.-N.; Gaborieau, L.; Karamchandani, J.; Beitel, L. K.; Fon, E. A.; Durcan, T.

10.1101/2022.02.25.482014 — neuroscience — Posted on 2022-02-25

303 Construction of a constitutively active type III secretion system for heterologous protein secretion

Liang, J. M.; Burdette, L. A.; Wong, H. T.; Tullman-Ercek, D.

10.1101/2022.02.24.481905 — synthetic biology — Posted on 2022-02-25

304 DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

Nan, Y.; Luo, Q.; Wu, X.; Liu, S.; Zhao, P.; Chang, W.; Liu, Z.

10.1101/2022.02.24.481869 — cancer biology — Posted on 2022-02-25

305 Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

Yuan, D.; Zhou, S.; Ni, H.; Yang, W.; Fang, X.; Gao, Y.; Shao, Z.; Bai, D.; Wu, Z.; Zou, J.; Liu, L.; Shi, J.; Zheng, N.; Yu, M.; Liu, Y.; Xiao, X.; Chen, B.; Gao, C.

10.1101/2022.02.24.481884 — biophysics — Posted on 2022-02-25

306 A new paradigm of multiheme cytochrome evolution by grafting and pruning protein modules

Soares, R.; Paquete, C. M.; Costa, N.; Andreini, C.; Louro, R. O. O.

10.1101/2022.02.24.481543 — biochemistry — Posted on 2022-02-25

307 Towards a New Model for the TREX1 Exonuclease

Hemphill, W. O.; Salsbury, F. R.; Perrino, F. W.

10.1101/2022.02.25.481063 — biochemistry — Posted on 2022-02-25

308 Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function

Patnaik, P. K.; Beaupere, C.; Barlit, H.; Romero, A. M.; Tsuchiya, M.; Muir, M.; Martinez-Pastor, M. T.; Puig, S.; Kaeberlein, M.; Labunskyy, V. M.

10.1101/2022.02.25.480133 — genomics — Posted on 2022-02-25

309 Quality assessment and refinement of chromatin accessibility data using a sequence-based predictive model

Han, S. K.; Muto, Y.; Wilson, P. C.; Chakravarti, A.; Humphreys, B. D.; Sampson, M. G.; Lee, D.

10.1101/2022.02.24.481844 — genomics — Posted on 2022-02-25

310 Novel mtDNA Imparts the Connective Tissue Disorder of a Tourette Pedigree

Schaefer, P. M.; Scherer Alves, L.; Lvova, M.; Huang, J.; Rathi, K.; Janssen, K.; Butic, A.; Yardeni, T.; Morrow, R.; Lott, M.; Keller, K.; Garcia, B.; Francomano, C. A.; Wallace, D. C.

10.1101/2022.02.25.481696 — genetics — Posted on 2022-02-25

311 Human HspB1, HspB3, HspB5 and HspB8: Shaping these Disease Factors during Vertebrate Evolution

Benndorf, R.; Velazquez, R.; Zehr, J. D.; Kosakovsky Pond, S. L.; Martin, J. L.; Lucaci, A. G.

10.1101/2022.02.24.481792 — evolutionary biology — Posted on 2022-02-25

312 Caecilian genomes reveal molecular basis of adaptation and convergent evolution of limblessness in snakes and caecilians.

Ovchinnikov, V.; Uliano-Silva, M.; Wilkinson, M.; Wood, J.; Smith, M.; Oliver, K.; Sims, Y.; Torrance, J.; Suh, A.; McCarthy, S.; Durbin, R.; O'Connell, M. J.

10.1101/2022.02.23.481419 — evolutionary biology — Posted on 2022-02-25

313 Bimodal breeding phenology in the parsley frog Pelodytes punctatus as a bet-hedging strategy in an unpredictable environment despite strong priority effects

Jourdan-Pineau, H.; Crochet, P.-A.; David, P.

10.1101/2022.02.24.481784 — evolutionary biology — Posted on 2022-02-25

314 Scrub encroachment promotes biodiversity in wetland restoration under eutrophic conditions

Brunbjerg, A. K.; Floejgaard, C.; Froeslev, T. G.; Andersen, D. K.; Bruun, H. H.; Dalby, L.; Goldberg, I.; Juhl Lehmann, L.; Moeslund, J. E.; Ejrnaes, R.

10.1101/2022.02.24.481733 — ecology — Posted on 2022-02-25

315 Stable iPSC-derived NKX2-1+ Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

Hein, R. F. C.; Conchola, A. S.; Fine, A.; Xiao, Z.; Frum, T.; Childs, C.; Tsai, Y.-H.; Holloway, E. M.; Huang, S.; Mahoney, J.; Spence, J. R.

10.1101/2022.02.25.481981 — developmental biology — Posted on 2022-02-25

316 Highly divergent white-tailed deer SARS-CoV-2 with potential deer-to-human transmission

Pickering, B.; Lung, O.; Maguire, F.; Kruczkiewicz, P.; Kotwa, J. D.; Buchanan, T.; Gagnier, M.; Guthrie, J.; Jardine, C.; Marchand-Austin, A.; Masse, A.; McClinchey, H.; Nirmalarajah, K.; Aftanas, P.; Blais-Savoie, J.; Chee, H.-Y.; Chien, E.; Yim, W.; Goolia, M.; Suderman, M.; Pinette, M.; Smith, G.; Sullivan, D.; Rudar, J.; Adey, E.; Nebroski, M.; Cote, M.; Laroche, G.; McGeer, A.; Nituch, L.; Mubareka, S.; Bowman, J.

10.1101/2022.02.22.481551 — microbiology — Posted on 2022-02-25

317 Variation in supplemental carbon dioxide requirements defines lineage-specific antibiotic resistance acquisition in Neisseria gonorrhoeae

Rubin, D. H.; Ma, K. C.; Westervelt, K. A.; Hullahalli, K.; Waldor, M. K.; Grad, Y. H.

10.1101/2022.02.24.481660 — microbiology — Posted on 2022-02-25

318 Identification of HIV-Reservoir Cells with Reduced Susceptibility to Antibody-Dependent Immune Response

Astorga-Gamaza, A.; Grau-Exposito, J.; Burgos, J.; Navarro, J.; Curran, A.; Planas, B.; Suanzes, P.; Falco, V.; Genesca, M.; Buzon, M. J.

10.1101/2022.02.24.481766 — immunology — Posted on 2022-02-25

319 Automated Analysis Pipeline for Extracting Saccade, Pupil, and Blink Parameters Using Video-Based Eye Tracking

Coe, B. C.; Huang, J.; Brien, D. C.; White, B. J.; Yep, R.; Munoz, D. P.

10.1101/2022.02.22.481518 — neuroscience — Posted on 2022-02-25

320 The circ_0002538/miR-138-5p/PLLP axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy

Liu, Y.; Xu, Z.; Liu, W.; Ren, S.; Xiong, H.; Jiang, T.; Chen, J.; Kang, Y.; Li, Q.; Wu, Z.; Machens, H.-G.; Yang, X.; Chen, Z.

10.1101/2022.02.24.481714 — neuroscience — Posted on 2022-02-25

321 Single-deletion-mutant, third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency

Jin, L.; Sullivan, H. A.; Zhu, M.; Lea, N. E.; Lavin, T. K.; Matsuyama, M.; Hou, Y.; Wickersham, I. R.

10.1101/2022.02.23.481706 — neuroscience — Posted on 2022-02-25

322 The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling

Laham, B. J.; Murthy, S.; Hanani, M.; Clappier, M.; Boyer, S.; Vasquez, B.; Gould, E.

10.1101/2022.02.23.481634 — neuroscience — Posted on 2022-02-25

323 Association Mapping Across a Multitude of Traits Collected in Diverse Environments Identifies Pleiotropic Loci in Maize.

Mural, R. V.; Sun, G.; Grzybowski, M.; Tross, M. C.; Jin, H.; Smith, C.; Newton, L.; Andorf, C. M.; Woodhouse, M. R.; Thompson, A. M.; Sigmon, B. V.; Schnable, J. C.

10.1101/2022.02.25.480753 — plant biology — Posted on 2022-02-25

324 Resource requirements for ecotoxicity testing: A comparison of traditional and new approach methods

Mittal, K.; Crump, D.; Head, J.; Hecker, M.; Hickey, G.; Maguire, S.; Hogan, N.; Xia, J.; Basu, N.

10.1101/2022.02.24.481630 — pharmacology and toxicology — Posted on 2022-02-25

325 Model-free analysis in the spectral domain of postmortem mouse brain EPSI reveals inconsistencies with model-based analyses of the free induction decay

Trinkle, S.; Wildenberg, G.; Kasthuri, N.; La Riviere, P.; Foxley, S.

10.1101/2022.02.24.481824 — biophysics — Posted on 2022-02-25

326 Wheat Panache - a pangenome graph database representing presence/absence variation across 16 bread wheat genomes

Bayer, P. E.; Petereit, J.; Durant, E.; Monat, C.; Rouard, M.; Hu, H.; Chapman, B.; Li, C.; Cheng, S.; Batley, J.; Edwards, D.

10.1101/2022.02.23.481560 — bioinformatics — Posted on 2022-02-25

327 Methods in Cognitive Pupillometry: Design, Preprocessing, and Statistical Analysis

Mathot, S.; Vilotijevic, A.

10.1101/2022.02.23.481628 — animal behavior and cognition — Posted on 2022-02-25

328 High coverage of single cell genomes by T7-assisted enzymatic methyl-sequencing

Tang, C.; Wang, J.; Fang, Y.; Chen, W.; Zhang, C.; Chen, Z.; Xie, Z.; Weng, Z.; Chen, W.; Ruan, F.; Xie, Y.; Sun, Y.; Guo, M.; Li, Y.

10.1101/2022.02.23.481567 — genomics — Posted on 2022-02-25

329 The impacts of transfer learning, phylogenetic distance, and sample size on big-data bioacoustics

Provost, K. L.; Yang, J.; Carstens, B. C.

10.1101/2022.02.24.481827 — evolutionary biology — Posted on 2022-02-25

330 Database-independent analysis of probable post-translational modifications of soil proteins across ecosystems

Starke, R.; Schaepe, S. S.; van den Bossche, T.; Martinovic, T.; Fernandes, M. L. P.; Delgado-Baquerizo, M.; Bastida, F.; Jehmlich, N.

10.1101/2022.02.24.481781 — ecology — Posted on 2022-02-25

331 Evolutionary emergence of alternative stable states in shallow lakes

Ardichvili, A. N.; Loeuille, N.; Dakos, V.

10.1101/2022.02.23.481597 — ecology — Posted on 2022-02-25

332 ABIOTIC STRESS GENE 1 mediates aroma volatiles accumulation by activating MdLOX1a in apple

Zhang, J.; Zhang, S.; Wang, Y.; Zhang, S.; Liu, W.; Wang, N.; Fang, H.; Zhang, Z.; Chen, X.

10.1101/2022.02.24.481825 — molecular biology — Posted on 2022-02-25

333 T cells use distinct topological and membrane receptor scanning strategies that individually coalesce during receptor recognition

Cai, E.; Beppler, C.; Eichorst, J.; Marchuk, K.; Krummel, M. F.

10.1101/2022.02.23.481517 — immunology — Posted on 2022-02-25

334 An open, analysis-ready, and quality controlled resource for pediatric brain white-matter research

Richie-Halford, A.; Cieslak, M.; Ai, L.; Caffarra, S.; Covitz, S.; Franco, A. R.; Karipidis, I. I.; Kruper, J.; Milham, M.; Avelar-Pereira, B.; Roy, E.; Sydnor, V. J.; Yeatman, J.; The Fibr Community Science Consortium, ; Satterthwaite, T. D.; Rokem, A.

10.1101/2022.02.24.481303 — neuroscience — Posted on 2022-02-25

335 The Development, but not Expression, of Alcohol Front-loading in C57BL/6J Mice Maintained on LabDiet 5001 is Abolished by Maintenance on Teklad 2920x Rodent Diet

Maphis, N. M.; Huffman, T. R.; Linsenbardt, D. N.

10.1101/2022.02.23.481358 — neuroscience — Posted on 2022-02-25

336 Organotopic organisation of the cervical vagus nerve

Thompson, N.; Ravagli, E.; Mastitskaya, S.; Iacoviello, F.; Stathopoulou, T.-R.; Perkins, J.; Shearing, P. R.; Aristovich, K.; Holder, D.

10.1101/2022.02.24.481810 — neuroscience — Posted on 2022-02-25

337 A Geometric View of Signal Sensitivity Metrics in multi-echo fMRI

Liu, T.; Li, B.; Fernandez, B.; Banerjee, S.

10.1101/2022.02.23.481688 — neuroscience — Posted on 2022-02-25

338 Load Non-Linearly Modulates Movement Reflex Gain in an Insect Leg via a Distributed Network of Identified Nonspiking Interneurons

Gebehart, C.; Hooper, S. L.; Büschges, A.

10.1101/2022.02.24.481822 — neuroscience — Posted on 2022-02-25

339 A role for thalamic projection GABAergic neurons in circadian responses to light

Brock, O.; Gelegen, C. E.; Salgarella, I.; Sully, P.; Jager, P.; Menage, L.; Mehta, I.; Jeczmien-Lazur, J.; Djama, D.; Strother, L.; Coculla, A.; Vernon, A. C.; Brickley, S.; Holland, P.; Cooke, S.; Delogu, A.

10.1101/2022.02.24.481804 — neuroscience — Posted on 2022-02-25

340 Astrocytic Ca2+ signals partake in inhibitory neurovascular coupling in a brain state-dependent manner.

Krogsgaard, A.; Sperling, L.; Dahlqvist, M.; Thomsen, K.; Vydmantaite, G.; Lauritzen, M.; Lind, B. L.

10.1101/2022.02.23.478942 — neuroscience — Posted on 2022-02-25

Rumschlag, J. A.; McClaskey, C. M.; Dias, J. W.; Kerouac, L. B.; Noble, K. V.; Panganiban, C.; Lang, H.; Harris, K. C.

10.1101/2022.02.23.481643 — neuroscience — Posted on 2022-02-25

342 Rich Experience Boosts Functional Connectome and High-Dimensional Coding in Hippocampal Network

Emery, B. A.; Hu, X.; Khanzada, S.; Kempermann, G.; Amin, H.

10.1101/2022.02.23.480123 — neuroscience — Posted on 2022-02-25

343 Dissecting the effects of adaptive encoding and predictive inference on a single perceptual estimation

Moon, J.; Kwon, O.-S.

10.1101/2022.02.24.481765 — neuroscience — Posted on 2022-02-25

344 A robust modular automated neuroimaging pipeline for model inputs to TheVirtualBrain

Frazier-Logue, N.; Wang, J.; Wang, Z.; Sodums, D.; Khosla, A.; Samson, A.; McIntosh, A. R.; Shen, K.

10.1101/2022.02.24.481836 — neuroscience — Posted on 2022-02-25

345 New insights into 4,000 years of resource economy across Greenland using ancient DNA

Seersholm, F. V.; Harmsen, H.; Gotfredsen, A. B.; Madsen, C. K.; Jensen, J. F.; Hollesen, J.; Meldgaard, M.; Bunce, M.; Hansen, A. J.

10.1101/2022.02.23.480846 — paleontology — Posted on 2022-02-25

346 Western diet unmasks transient low-level vinyl chloride exposure-induced tumorigenesis; potential role of the (epi-)transcriptome

Liu, S.; He, L.; Bannister, O.; Schnegelberger, R.; Tao, J.; Althouse, A.; Schopfer, F. J.; Wahlang, B.; Cave, M. C.; Monga, S. P.; Zhang, X.; Arteel, G. E.; Beier, J. I.

10.1101/2022.02.24.481808 — cancer biology — Posted on 2022-02-25

347 Time-lagged Flux in the Transition Path Ensemble: Flux Maximization and Relation to Transition Path Theory

Li, W.

10.1101/2022.02.23.481712 — biophysics — Posted on 2022-02-25

348 xcore: an R package for inference of gene expression regulators

Migdał, M.; Winata, C. L.; Arakawa, T.; Takizawa, S.; Furuno, M.; Suzuki, H.; Arner, E.; Kaczkowski, B.

10.1101/2022.02.23.481130 — bioinformatics — Posted on 2022-02-25

349 Intentional stocking undermines ecological stability

Terui, A.; Urabe, H.; Senzaki, M.; Nishizawa, B.

10.1101/2022.02.24.481650 — ecology — Posted on 2022-02-25

350 Direct and delayed synergistic effects of marine heatwaves, metals and food limitation on tropical reef-associated fish larvae

Le, M.-H.; Dinh, K. V.; Vo, X. T.; Pham, H. Q.

10.1101/2022.02.23.481600 — ecology — Posted on 2022-02-25

351 Copepod functional traits and groups show contrasting biogeographies in the global ocean

Benedetti, F.; Wydler, J.; Vogt, M.

10.1101/2022.02.24.481747 — ecology — Posted on 2022-02-25

352 Development of duplex real time PCR for quick detection of Cryptosporidia in goats

Sharma, A. K.; Gururaj, K.; Sharma, R.; Goel, A.; Paul, S.; Sharma, D. K.

10.1101/2022.02.23.481731 — molecular biology — Posted on 2022-02-25

353 Differential recognition of computationally optimized H3 hemagglutinin influenza vaccine candidates by human antibodies

Abbadi, N.; Nagashima, K.; Pena-Briseno, A.; Ross, T.; Mousa, J. J.

10.1101/2022.02.24.481830 — immunology — Posted on 2022-02-25

354 Phospho-proteomic analysis of CAR-T cell signaling following activation by antigen-presenting cancer cells

MacMullan, M. A.; Dunn, Z. S.; Qu, Y.; Wang, P.; Graham, N. A.

10.1101/2022.02.24.481820 — immunology — Posted on 2022-02-25

355 Genetic deletion of Kiaa1109 in mice leads to developmental defects at the neuromuscular junction

Liu, Y.; Lin, W.

10.1101/2022.02.23.481678 — neuroscience — Posted on 2022-02-25

356 Investigation on How Dynamic Effective Connectivity Patterns Encode the Fluctuating Pain Intensity in Chronic Migraine

Bassez, I.; Van de Steen, F.; Hackl, S.; Jahn, P.; Mayr, A.; Marinazzo, D.; Schulz, E.

10.1101/2022.02.23.481583 — neuroscience — Posted on 2022-02-25

357 Dynamic Synchronization between Hippocampal Spatial Representations and the Stepping Rhythm

Joshi, A.; Denovellis, E. L.; Mankili, A.; Meneksedag, Y.; Davidson, T.; Gillespie, A. K.; Guidera, J. A.; Roumis, D.; Frank, L. M.

10.1101/2022.02.23.481357 — neuroscience — Posted on 2022-02-25

358 A key role of orientation in the coding of visual motion direction

Moon, J.; Tadin, D.; Kwon, O.-S.

10.1101/2022.02.24.481759 — neuroscience — Posted on 2022-02-25

359 Structural and functional alterations of neuromuscular synapses in a mouse model of ACTA1 congenital myopathy

Liu, Y.; Lin, W.

10.1101/2022.02.23.481672 — neuroscience — Posted on 2022-02-25

360 Categorical bias as a crucial parameter in visual working memory: the effect of memory load and retention interval

Zhou, C.; Lorist, M. M.; Mathot, S.

10.1101/2022.02.23.481291 — neuroscience — Posted on 2022-02-25

361 Olfactory responses of Drosophila are encoded in the organization of projection neurons

Hyeon, C.; Choi, K.; Kim, W. K.

10.1101/2022.02.23.481655 — neuroscience — Posted on 2022-02-25

362 Persistent horizontal and vertical, MR-induced nystagmus in resting state Human Connectome Project data

Go, C. C.-f.; Taskin, H. O.; Ahmadi, S.-A.; Frazetta, G.; Cutler, L.; Malhotra, S.; Morgan, J. I.; Flanagin, V. L.; Aguirre, G. K.

10.1101/2022.02.23.481619 — neuroscience — Posted on 2022-02-25

363 Active exploration of a novel environment drives the activation of the hippocampus-amygdala complex of domestic chicks.

Morandi-Raikova, A.; Mayer, U.

10.1101/2022.02.24.481770 — neuroscience — Posted on 2022-02-25

364 Manipulation-specific activity in motor and somatosensory cortex as mice handle food

Barrett, J. M.; Shepherd, G. M. G.

10.1101/2022.02.23.481687 — neuroscience — Posted on 2022-02-25

365 Performance reserves in brain-imaging-based phenotype prediction

Schulz, M.-A.; Bzdok, D.; Haufe, S.; Haynes, J.-D.; Ritter, K.

10.1101/2022.02.23.481601 — neuroscience — Posted on 2022-02-25

366 Multisensory interactions on auditory and somatosensory information in expert pianists

Hirano, M.; Furuya, S.

10.1101/2022.02.23.481694 — neuroscience — Posted on 2022-02-25

367 Automatic Generation of Interactive Multidimensional Phase Portraits

Ogunsan, O. O.; Lobo, D.

10.1101/2022.02.23.481676 — systems biology — Posted on 2022-02-25

368 The effect of carbamazepine on bone structure and strength in control and Osteogenesis Imperfecta (Col1a2 +/p.G610C) mice

Blank, M.; McGregor, N. E.; Rowley, L.; Kung, L. H.; Crimeen-Irwin, B.; Poulton, I. J.; Walker, E. C.; Gooi, J. H.; Lamande, S. R.; Sims, N.; Bateman, J. F.

10.1101/2022.02.23.481692 — pathology — Posted on 2022-02-25

369 A nucleation-and-growth model for the packaging of genome in linear virus-like particles: impact of multiple packaging signals

de Bruijn, R.; Wielstra, R. P.; Calcines Cruz, C.; van Waveren, T.; Hernandez-Garcia, A.; van der Schoot, P.

10.1101/2022.02.24.481677 — biophysics — Posted on 2022-02-25

370 StabMap: Mosaic single cell data integration using non-overlapping features

Ghazanfar, S.; Guibentif, C.; Marioni, J.

10.1101/2022.02.24.481823 — bioinformatics — Posted on 2022-02-25

371 Uncertainty Quantification in Variable Selection for Genetic Fine-Mapping using Bayesian Neural Networks

Cheng, W.; Ramachandran, S.; Crawford, L.

10.1101/2022.02.23.481675 — bioinformatics — Posted on 2022-02-25

372 Comparing algorithms for assessing upper limb use with inertial measurement units

Subash, T.; David, A.; ReetaJanetSurekha, S.; Gayathri, S.; Samuelkamaleshkumar, S.; Magimairaj, H. P.; Malesevic, N.; Antfolk, C.; SKM, V.; Melendez-Calderon, A.; Balasubramanian, S.

10.1101/2022.02.24.481756 — bioengineering — Posted on 2022-02-25

373 A three-dimensional human adipocyte model of fatty acid-induced obesity

Pieters, V. M.; Rjaibi, S. T.; Singh, K.; Li, N. T.; Khan, S. T.; Nunes, S. S.; Dal Cin, A.; Gilbert, P. M.; McGuigan, A. P.

10.1101/2022.02.24.481624 — bioengineering — Posted on 2022-02-25

374 Genetic immune escape landscape in primary and metastatic cancer

Martinez-Jimenez, F.; Priestley, P.; Shale, C.; Baber, J.; Rozemuller, E.; Cuppen, E.

10.1101/2022.02.23.481444 — genomics — Posted on 2022-02-25

375 The evolution of recombination in self-fertilizing organisms

Stetsenko, R.; Roze, D.

10.1101/2022.02.24.481800 — evolutionary biology — Posted on 2022-02-25

376 Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein level changes

Kar, F. M.; Vogel, C.; Hochwagen, A.

10.1101/2022.02.24.481857 — cell biology — Posted on 2022-02-25

377 Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis

Ichikawa, K.; Nakamura, Y.; Bono, H.; Ezaki, R.; Matsuzaki, M.; Horiuchi, H.

10.1101/2022.02.24.481709 — developmental biology — Posted on 2022-02-25

378 TraB is a novel component of the ER-Mitochondria contact site (EMCS) with dual roles in ER-Mitochondrial tethering and mitophagy

Li, C.; Duckney, P.; Zhang, T.; Fu, Y.; Li, X.; Kroon, J.; De Jaeger, G.; Cheng, Y.; Hussey, P. J.; Wang, P.

10.1101/2022.02.25.481886 — cell biology — Posted on 2022-02-25

379 Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Matkovic, J.; Ghosh, S.; Cosic, M.; Pavin, N.; Tolic, I. M.

10.1101/2022.02.25.481924 — cell biology — Posted on 2022-02-25

380 An apical membrane complex controls rhoptry exocytosis and invasion in Toxoplasma

Sparvoli, D.; Delabre, J.; Penarete-Vargas, D. M.; Kumar Mageswaran, S.; Tsypin, L. M.; Heckendorn, J.; Theveny, L.; Maynadier, M.; Mendonca Cova, M.; Berry-Sterkers, L.; Guerin, A.; Dubremetz, J.-F.; Urbach, S.; Striepen, B.; Turkewitz, A. P.; Chang, Y.-W.; LEBRUN, M.

10.1101/2022.02.25.481937 — cell biology — Posted on 2022-02-25

381 Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

Mittal, K.; Lee, B. P.; Cooper, G. W.; Shim, J.; Jonus, H. C.; Kim, W. J.; Doshi, M.; Almanza, D.; Kynnap, B. D.; Christie, A. L.; Yang, X.; Cowley, G. S.; Leeper, B. A.; Morton, C. L.; Dwivedi, B.; Lawrence, T.; Rupji, M.; Keskula, P.; Meyer, S.; Clinton, C. M.; Bhasin, M.; Crompton, B.; Tseng, Y.-Y.; Boehm, J. S.; Ligon, K. L.; Root, D. E.; Murphy, A. J.; Weinstock, D. M.; Gokhale, P. C.; Spangle, J. M.; Rivera, M. N.; Mullen, E. A.; Stegmaier, K.; Goldsmith, K. C.; Hahn, W. C.; Hong, A. L.

10.1101/2022.02.23.481521 — cancer biology — Posted on 2022-02-25

382 CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

Ramos, E. K.; Tsai, C.-F.; Dashzeveg, N. K.; Jia, Y.; Cao, Y.; Manu, M.; Taftaf, R.; Hoffmann, A. D.; El-Shennawy, L.; Gritsenko, M. A.; Adorno-Cruz, V.; Schuster, E. J.; Scholten, D.; Patel, D.; Liu, X.; Patel, P.; Wray, B.; Zhang, Y.; Zhang, S.; Moore, R. J.; Schipma, M. J.; Liu, T.; Tokars, V. L.; Cristofanilli, M.; Shi, T.; Shen, Y.; Liu, H.

10.1101/2022.02.23.481674 — cancer biology — Posted on 2022-02-25

383 Stepwise remodelling and subcompartment formation in individual vesicles by three ESCRT-III proteins

Avalos-Padilla, Y.; Georgiev, V. N.; Ewins, E. J.; Robinson, T.; Orozco, E.; Lipowsky, R.; Dimova, R.

10.1101/2022.02.25.481928 — biophysics — Posted on 2022-02-25

384 Zebrafish Neuromesodermal Progenitors Undergo a Critical State Transition in vivo

Toh, K.; Saunders, D.; Verd, B.; Steventon, B.

10.1101/2022.02.25.481986 — developmental biology — Posted on 2022-02-25

385 Phylogeny of the genus Dolichopus Latreille, 1796 and testing for phylogenetic signal in morphological characters and morphometric data

Chursina, M. A.; Grichanov, I. Y.

10.1101/2022.02.24.481773 — zoology — Posted on 2022-02-25

386 Mitochondrial Genome of Garcinia mangostana L. variety Mesta

Wee, C.-C.; Nor Muhammad, N. A.; Subbiah, V. K.; Arita, M.; Nakamura, Y.; Goh, H.-H.

10.1101/2022.02.23.481586 — plant biology — Posted on 2022-02-25

387 Neprosin belongs to the glutamic peptidase family G3 based on in silico evidence

Ting, T. Y.; Baharin, A.; Ramzi, A. B.; Ng, C. L.; Goh, H.-H.

10.1101/2022.02.22.481544 — plant biology — Posted on 2022-02-25

388 Plastomes of Garcinia mangostana L. and comparative analysis with other Garcinia species

Wee, C. C.; Nor Muhammad, N. A.; Subbiah, V. K.; Arita, M.; Nakamura, Y.; Goh, H.-H.

10.1101/2022.02.22.481552 — plant biology — Posted on 2022-02-25

389 Are tropical hummingbird pollination networks resistant to experimental extirpation of a common flowering plant?

Leimberger, K. G.; Hadley, A. S.; Frey, S. J. K.; Betts, M. G.

10.1101/2022.02.24.481682 — ecology — Posted on 2022-02-25

390 Chloroplast genome assemblies and comparative analyses of major Vaccinium berry crops

Fahrenkrog, A. M.; Matsumoto, G.; Toth, K.; Jokipii-Lukkari, S.; Salo, H. M.; Haggman, H.; Benevenuto, J.; Munoz, P.

10.1101/2022.02.23.481500 — plant biology — Posted on 2022-02-25

391 Local light signalling at the leaf tip drives remote differential petiole growth through auxin-gibberellin dynamics

Kupers, J. J.; Snoek, B. L.; Oskam, L.; Pantazopoulou, C. K.; Matton, S. E. A.; Reinen, E.; Liao, C.-Y.; Eggermont, E. D. C.; Weekamp, H.; Kohlen, W.; Weijers, D.; Pierik, R.

10.1101/2022.02.25.481815 — plant biology — Posted on 2022-02-25

392 Domestication and lowland adaptation of coastal preceramic maize from Paredones, Peru

Vallebueno-Estrada, M.; Hernandez-Robles, G. G.; Gonzalez-Orozco, E.; Lopez-Valdivia, I.; Tham, T. R.; Sanchez, V. V.; Swarts, K.; Dillehay, T. D.; Vielle-Calzada, J.-P.; Montiel, R.

10.1101/2022.02.23.481166 — plant biology — Posted on 2022-02-25

393 An Agrobacterium strain auxotrophic for methionine is useful for switchgrass transformation

Prias-Blanco, M.; Chappell, T. M.; Freed, E. F.; Berenguer, E. I.; Eckert, C. A.; Parrott, W. A.

10.1101/2022.02.24.481806 — plant biology — Posted on 2022-02-25

394 Initiation of aboveground organ primordia depends on combined action of auxin, ERECTA family genes, and PINOID.

DeGennaro, D.; Urquidi-Camacho, R. A.; Zhang, L.; Shpak, E. D.

10.1101/2022.02.24.481843 — plant biology — Posted on 2022-02-25

395 Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2

Hung, F.-Y.; Feng, Y.-R.; Shih, Y.-H.; Lai, Y.-C.; Wu, K.

10.1101/2022.02.23.481647 — plant biology — Posted on 2022-02-25

396 Dynamic Generalised Additive Models (DGAM) for forecasting discrete ecological time series

Clark, N. J.; Wells, K.

10.1101/2022.02.22.481550 — ecology — Posted on 2022-02-25

397 High Cellular Uptake Gene Delivery Platform with Chitosan and L-arginine Complex for Cancer Treatment

Wang, M.; Zhang, H.; Yang, C.

10.1101/2022.02.22.481395 — bioengineering — Posted on 2022-02-25

398 Single cell analysis of the aging female hypothalamus

Hajdarovic, K. H.; Yu, D.; Hassell, L.-A.; Evans, S. A.; Packer, S.; Neretti, N.; Webb, A. E.

10.1101/2021.03.07.434282 — neuroscience — Posted on 2022-02-25

399 The phase of sensorimotor mu and beta oscillations has the opposite effect on corticospinal excitability

Wischnewski, M.; Haigh, Z. J.; Shirinpour, S.; Alekseichuk, I.; Opitz, A.

10.1101/2022.02.22.481530 — neuroscience — Posted on 2022-02-25

400 Uncovering circuit mechanisms of current sinksand sources with biophysical simulations ofprimary visual cortex

Rimehaug, A. E.; Stasik, A. J.; Hagen, E.; Billeh, Y. N.; Siegle, J. H.; Dai, K.; Olsen, S. R.; Koch, C.; Einevoll, G. T.; Arkhipov, A.

10.1101/2022.02.22.481540 — neuroscience — Posted on 2022-02-25

401 Negative Impact of Daily Screen Use on Inhibitory Control Network in Preadolescence: A Two Year Follow-Up Study

Chen, Y.-Y.; Yim, H.; Lee, T.-H.

10.1101/2022.02.22.481547 — neuroscience — Posted on 2022-02-25

402 Multiple bumps can enhance robustness to noise in continuous attractor networks

Wang, R.; Kang, L.

10.1101/2022.02.22.481545 — neuroscience — Posted on 2022-02-25

403 Single-Case Disconnectome Lesion-symptom Mapping: Identifying Two Subtypes of Limb Apraxia

Metzgar, R.; Stoll, H.; Grafton, S.; Buxbaum, L. J.; Garcea, F.

10.1101/2022.02.22.481524 — neuroscience — Posted on 2022-02-25

404 Intermittent Fasting Mitigates Vascular and Neuronal Pathologies in a Mouse Model of Vascular Dementia

Rajeev, V.; Fann, D. Y.; Dinh, Q. N.; Kim, H. A.; De Silva, T. M.; Jo, D.-G.; Drummond, G. R.; Sobey, C. G.; Lai, M. K. P.; Chen, C. L.-H.; Arumugam, T. V.

10.1101/2022.02.22.481534 — neuroscience — Posted on 2022-02-25

405 The gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction

Bosi, E.; Marchetti, P.; Rutter, G. A.; Eizirik, D. L.

10.1101/2022.02.22.481528 — physiology — Posted on 2022-02-25

406 Quantitative Evaluation of Nonlinear Methods for Population Structure Visualization & Inference

Ubbens, J.; Feldmann, M. J.; Stavness, I.; Sharpe, A. G.

10.1101/2022.02.22.481549 — bioinformatics — Posted on 2022-02-25

407 In vitro evolution of Listeria monocytogenes reveals selective pressure for loss of SigB and AgrA function at different incubation temperatures.

Guerreiro, D. N.; Wu, J.; McDermott, E.; Garmyn, D.; Dockery, P.; Boyd, A.; Piveteau, P.; O'Byrne, C. P.

10.1101/2022.02.23.481730 — molecular biology — Posted on 2022-02-25

408 Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways

Petcherski, A.; Sharma, M.; Daskou, M.; Satta, S.; Vasilopoulos, H.; Hugo, C.; Ritou, E.; Dillon, B. J.; Fung, E.; Garcia, G.; Scafoglio, C.; Purkayastha, A.; Gomperts, B.; Fishbein, G. A.; Arumugaswami, V.; Liesa, M.; Shirihai, O. S.; Kelesidis, T.

10.1101/2022.02.22.481100 — microbiology — Posted on 2022-02-25

409 Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

Oda, T.; Yanagisawa, H.; Shinmori, H.; Ogawa, Y.; Kawamura, T.

10.1101/2022.02.24.481763 — immunology — Posted on 2022-02-25

410 Identification of candidate virulence loci in Striga hermonthica, a devastating parasite of African cereal crops

Qiu, S.; Bradley, J. M.; Zhang, P.; Chaudhuri, R.; Blaxter, M.; Butlin, R. K.; Scholes, J. D.

10.1101/2022.01.13.476148 — plant biology — Posted on 2022-02-25

411 CXCR2 inhibition enables NASH-HCC immunotherapy

Leslie, J.; Mackey, J. B. G.; Jamieson, T.; Ramon-Gil, E.; Drake, T. M.; Fercoq, F.; Clark, W.; Gilroy, K.; Hedley, A.; Nixon, C.; Luli, S.; Laszczewska, M.; Pinyol, R.; Esteban-Fabro, R.; Willoughby, C. E.; Haber, P. K.; Andreu-Oller, C.; Rahbari, M.; Fan, C.; Pfister, D.; Raman, S.; Wilson, N.; Muller, M.; Collins, A.; Geh, D.; Fuller, A.; McDonald, D.; Hulme, G.; Filby, A.; Cortes-Lavaud, X.; Mohamed, N.-E.; Ford, C. A.; Raffo Iraolagoitia, X. L.; MacFalane, A. J.; McCain, M.; Ridgeway, R.; Roberts, E. W.; Barry, S. T.; Graham, G. J.; Heikenwalder, M.; Reeves, H. L.; Llovet, J. M.; Carlin,

10.1101/2022.02.24.481779 — cancer biology — Posted on 2022-02-25

412 Odysseia: Genetic Regulatory Feature Analysis with Interpretable Classification Machine Learning Models

Yu, G.; Tao, J.; Wang, J.

10.1101/2022.02.17.480852 — bioinformatics — Posted on 2022-02-25

413 Ribosome profiling reveals the translational landscape and allele-specific translation efficiency in rice

Zhu, X.-T.; Zhou, R.; Che, J.; Zheng, Y.-Y.; Qamar, M. T. u.; Feng, J.-W.; Zhang, J.; Gao, J.; Chen, L.-L.

10.1101/2022.02.22.481533 — bioinformatics — Posted on 2022-02-25

414 Comparison of Transcranial Doppler Ultrasound with Computational Fluid Dynamics: Responses to Physiological Stimuli

Caddy, H. T.; Thomas, H. J.; Kelsey, L. J.; Smith, K. J.; Doyle, B. J.; Green, D. J.

10.1101/2022.02.22.480470 — bioengineering — Posted on 2022-02-25

415 Genetic resistance to yellow rust infection of the wheat ear is controlled by genes controlling foliar resistance and flowering time

Bouvet, L.; Percival-Alwyn, L.; Berry, S.; Fenwick, P.; Holdgate, S.; Mackay, I. J.; Cockram, J.

10.1101/2021.04.27.441654 — genetics — Posted on 2022-02-25

416 Evolution and systematics of the Aculeata and kin (Hymenoptera),with emphasis on the ants (Formicoidea: {dagger}@@@idae fam. nov., Formicidae).

Boudinot, B. E.; Khouri, Z.; Richter, A.; van de Kamp, T.; Griebenow, Z. H.; Perrichot, V.; Barden, P.

10.1101/2022.02.20.480183 — evolutionary biology — Posted on 2022-02-25

417 Actin turnover protects the cytokinetic contractile ring from structural instability

McDargh, Z. A.; Zhu, T.; Zhu, H.; O'Shaughnessy, B.

10.1101/2022.02.23.481727 — cell biology — Posted on 2022-02-25

418 The incentive circuit: memory dynamics in the mushroom body of Drosophila melanogaster

Gkanias, E.; McCurdy, L. Y.; Nitabach, M. N.; Webb, B.

10.1101/2021.06.11.448104 — neuroscience — Posted on 2022-02-25

419 Prediction and preview strongly affect reading times but not skipping during natural reading

Heilbron, M.; van Haren, J.; Hagoort, P.; de Lange, F. P.

10.1101/2021.10.06.463362 — neuroscience — Posted on 2022-02-25

420 SUCCESSFUL IN VITRO EMBRYO PRODUCTION WITH OOCYTES ASPIRATED FROM LIVE WHITE-TAILED DEER (Odocoileus virginianus texanus) DONNORS UNDER CAPTIVITY IN NORTHEAST MEXICO

MarabotoM., E. E.; Trejo M., F. J.; Del Angel R., H.; Rosales H., J.; Bautista M., Y.; Torres P., L. I.; Gonzalez-Reyna, A.

10.1101/2022.02.18.481106 — zoology — Posted on 2022-02-25

421 Low-cost and open-source super-resolution fluorescence microscope with autofocus for teaching and research

Hanselman, J. D.; Kopek, B. G.

10.1101/2022.02.22.481481 — scientific communication and education — Posted on 2022-02-25

422 Evaluation of Three Forms of Rhizoctonia solani Mediated Pathogenicity to Sugar Beet Cultivars in Greenhouse Studies

Haque, M. E.; Parvin, M. S.

10.1101/2022.02.20.481202 — plant biology — Posted on 2022-02-25

423 A novel bacteriocin produced by Bifidobacterium longum subsp. infantis has dual antimicrobial and immunomodulatory activity

Javvadi, S. G.; Kujawska, M.; Papp, D.; Gontarczyk, A. M.; Jordan, A.; Lawson, M. A.; O'Neill, I. J.; Alcon-Giner, C.; Kiu, R.; Clarke, P.; Beraza, N.; Hall, L. J.

10.1101/2022.01.27.477972 — microbiology — Posted on 2022-02-25

424 Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter

Mourkas, E.; Yahara, K.; Bayliss, S. C.; Calland, J. K.; Johansson, H.; Mageiros, L.; Munoz-Ramirez, Z. Y.; Futcher, G.; Meric, G.; Hitchings, M. D.; Sandoval-Motta, S.; Torres, J.; Jolley, K. A.; Maiden, M. C.; Ellstrom, P.; Waldenstrom, J.; Pascoe, B.; Sheppard, S. K.

10.1101/2021.08.24.457495 — microbiology — Posted on 2022-02-25

425 Increased vulnerability of Purkinje cells in the posterior cerebellum of SCA1 mice is associated with molecular and cellular alterations related to disease pathology

Hamel, K.; Sheeler, C.; Rosa, J.-G.; Gilliat, S.; Zhang, Y.; Cvetanovic, M.

10.1101/2022.02.24.481789 — neuroscience — Posted on 2022-02-25

426 Moderate ethanol consumption interacts with Aβ to exacerbate Alzheimer's-like pathological, behavioral, and metabolic deficits in mice

Gironda, S. C.; Day, S. M.; Clarke, C. W.; Snipes, J. A.; Nicol, N. I.; Kamran, H.; Vaughan, W.; Macauley, S. L.; Weiner, J. L.

10.1101/2022.02.18.481066 — neuroscience — Posted on 2022-02-25

427 Three membrane fusion pore families determine the pathway to pore dilation

Su, R.; Wang, S.; McDargh, Z. A.; O'Shaughnessy, B.

10.1101/2022.02.23.481713 — biophysics — Posted on 2022-02-25

428 Shortcuts in stochastic systems and control of biophysical processes

Ilker, E.; Güngör, O.; Kuznets-Speck, B.; Chiel, J.; Deffner, S.; Hinczewski, M.

10.1101/2021.06.13.448255 — biophysics — Posted on 2022-02-25

429 Reduced Dimension, Biophysical Neuron Models Constructed From Observed Data

Clark, R. E.; Fuller, L.; Platt, J. A.; Abarbanel, H.

10.1101/2021.12.03.471194 — biophysics — Posted on 2022-02-25

430 Cloud-enabled Fiji for reproducible, integrated and modular image processing

Hung, L.-H.; Straw, E.; Reddy, S.; Schmitz, R.; Colburn, Z.; Yeung, K. Y.

10.1101/2021.10.22.465513 — bioinformatics — Posted on 2022-02-25

431 Inference of disease-associated microbial biomarkers based on metagenomic and metatranscriptomic data

Liu, Z.; Wang, Q.; Ma, A.; Chung, D.; Zhao, J.; Ma, Q.; Liu, B.

10.1101/2021.09.13.460160 — bioinformatics — Posted on 2022-02-25

432 Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation

Vandiver, A. R.; Pielstick, B.; Gilpatrick, T.; Hoang, A.; Vernon, H.; Wanagat, J.; Timp, W.

10.1101/2022.02.23.480720 — genomics — Posted on 2022-02-25

433 Causes of variability in estimates of mutational variance from mutation accumulation experiments

Conradsen, C.; Blows, M. W.; McGuigan, K.

10.1101/2021.07.07.451460 — genetics — Posted on 2022-02-25

434 Shorter effective lifespan in laboratory populations of D. melanogaster might reduce sexual selection.

Mital, A.; Sarangi, M.; Nandy, B.; Pandey, N.; Joshi, A.

10.1101/2021.04.09.439133 — evolutionary biology — Posted on 2022-02-25

435 A genomic assessment of the marine-speciation paradox within the toothed whale superfamily Delphinoidea

Westbury, M. V.; Cabrera, A. A.; Rey-Iglesia, A.; De Cahsan, B.; Duchene, D. A.; Hartmann, S.; Lorenzen, E. D.

10.1101/2020.10.23.352286 — evolutionary biology — Posted on 2022-02-25

436 Phenotypic and transcriptional response of Daphnia pulicaria to the combined effects of temperature and predation

Oliver, A.; Cavalheri, H. B.; Lima, T. G.; Jones, N. T.; Podell, S.; Zarate, D.; Allen, E.; Burton, R. S.; Shurin, J. B.

10.1101/2022.02.24.481768 — ecology — Posted on 2022-02-25

437 Evolutionary conservation of centriole rotational asymmetry in the human centrosome

GAUDIN, N.; MARTIN GIL, P.; BOUMENDJEL, M.; ERSHOV, D.; PIOCHE-DURIEU, C.; BOUIX, M.; DELOBELLE, Q.; MANISCALCO, L.; PHAN, T. B. N.; HEYER, V.; REINA-SAN-MARTIN, B.; AZIMZADEH, J.

10.1101/2021.07.21.453218 — cell biology — Posted on 2022-02-25

438 Community Composition of Bacteria Isolated from Swiss Banknotes Varies Depending on Collection Environment

Bischofberger, A. M.; Hall, A. R.

10.1101/2021.12.01.470750 — microbiology — Posted on 2022-02-25

439 Myelin lipids as nervous system energy reserves

Asadollahi, E.; Trevisiol, A.; Saab, A. S.; Looser, Z. J.; Dibaj, P.; Kusch, K.; Ruhwedel, T.; Moebius, W.; Jahn, O.; Baes, M.; Weber, B.; Abel, E. D.; Ballabio, A.; Popko, B.; Kassmann, C. M.; Ehrenreich, H.; Hirrlinger, J.; Nave, K.-A.

10.1101/2022.02.24.481621 — neuroscience — Posted on 2022-02-25

440 Influence of claustrum on cortex varies by area, layer, and cell type

McBride, E. G.; Gandhi, S. R.; Kuyat, J. R.; Ollerenshaw, D. R.; Arkhipov, A.; Koch, C.; Olsen, S. R.

10.1101/2022.02.22.481532 — neuroscience — Posted on 2022-02-25

441 A Novel and Functionally Diverse Class of Acetylcholine-gated Ion Channels

Hardege, I.; Morud, J.; Courtney, A.; Schafer, W. R.

10.1101/2021.10.06.463318 — neuroscience — Posted on 2022-02-25

442 The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping

Matchin, W.; den Ouden, D.-B.; Hickok, G.; Hillis, A. E.; Bonilha, L.; Fridriksson, J.

10.1101/2021.10.25.465746 — neuroscience — Posted on 2022-02-25

443 Age influences audiovisual speech processing in multi-talker scenarios - Evidence from cortical oscillations

Begau, A.; Klatt, L.-I.; Schneider, D.; Wascher, E.; Getzmann, S.

10.1101/2022.02.23.481314 — neuroscience — Posted on 2022-02-25

444 Arousal state affects perceptual decision-making by modulating hierarchical sensory processing in a large-scale visual system model

Sörensen, L. K. A.; Bohte, S. M.; Slagter, H. A.; Scholte, H. S.

10.1101/2021.05.19.444798 — neuroscience — Posted on 2022-02-25

445 Electric shock causes fear-like persistent behavioral response in the nematode Caenorhabditis elegans

Tee, L. F.; Young, J. J.; Suzuki, R.; Maruyama, K.; Endo, Y.; Kimura, K. D.

10.1101/2021.09.07.459218 — neuroscience — Posted on 2022-02-25

446 Detection of functional activity in brain white matter using fiber architecture informed synchrony mapping

Zhao, Y.; Gao, Y.; Zu, Z.; Li, M.; Schilling, K.; Anderson, A.; Ding, Z.; Gore, J.

10.1101/2022.02.23.481698 — neuroscience — Posted on 2022-02-25

447 Integrative small and long RNA-omics analysis of human healing and non-healing wounds discovers cooperating microRNAs as therapeutic targets

Liu, Z.; Zhang, L.; Toma, M. A.; Li, D.; Bian, X.; Pastar, I.; Tomic-Canic, M.; Sommar, P.; Xu Landen, N.

10.1101/2021.12.17.473103 — systems biology — Posted on 2022-02-25

448 Topology and adenocarcinoma cell localization dataset on the labyrinthin biomarker.

Babich, M.; Sharma, A.; Li, T.; Radosevich, J. A.

10.1101/2021.12.07.471613 — cancer biology — Posted on 2022-02-25

449 A combined test for feature selection on sparse metaproteomics data - an alternative to missing value imputation

Plancade, S.; Berland, M.; Blein Nicolas, M.; Langella, O.; Bassignani, A.; Juste, C.

10.1101/2021.06.22.449387 — bioinformatics — Posted on 2022-02-25

450 UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues

Yapp, C.; Novikov, E.; Jang, W.-D.; Vallius, T.; Chen, Y.-A.; Cicconet, M.; Maliga, Z.; Jacobson, C. A.; Wei, D.; Santagata, S.; Pfister, H.; Sorger, P. K.

10.1101/2021.04.02.438285 — bioinformatics — Posted on 2022-02-25

451 Oxidation-reduction and photophysical properties of isomeric forms of Safranin

Andersen, E. M. E.; Wang, H.; Khoo, J. S. H.; Cerda, J. F.; Koder, R. L.

10.1101/2022.02.24.481769 — biochemistry — Posted on 2022-02-24

452 Multi-eGO: an in-silico lens to look into protein aggregation kinetics at atomic resolution

Scalone, E.; Broggini, L.; Visentin, C.; Erba, D.; Bacic Toplek, F.; Peqini, K.; Pellegrino, S.; Ricagno, S.; Paissoni, C.; Camilloni, C.

10.1101/2022.02.18.481033 — biochemistry — Posted on 2022-02-25

453 Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits

Kubota, N.; Suyama, M.

10.1101/2022.02.24.481875 — genomics — Posted on 2022-02-25

454 Sea anemone genomes reveal ancestral metazoan chromosomal macrosynteny

Zimmermann, B.; Robb, S. M. C.; Genikhovich, G.; Fropf, W. J.; Weilguny, L.; He, S.; Chen, S.; Lovegrove-Walsh, J.; Hill, E. M.; Chen, C.-Y.; Ragkousi, K.; Praher, D.; Fredman, D.; Moran, Y.; Gibson, M. C.; Technau, U.

10.1101/2020.10.30.359448 — genomics — Posted on 2022-02-25

455 Changes in body shape implicate cuticle stretch in C. elegans growth control

Nyaanga, J.; Goss, C.; Zhang, G.; Ahmed, H. N.; Andersen, E. J.; Miller, I. R.; Rozenich, J. K.; Swarthout, I. L.; Vaughn, J. A.; Andersen, E. C.; Mangan, N. M.; Shirman, S.

10.1101/2021.04.01.438121 — developmental biology — Posted on 2022-02-25

456 Cell-to-cell variations in subcellular localisation of V2R are independent of its expression level

Koers, E. J.; Morgan, B. A.; Heydenreich, F.; Plouffe, B.; Styles, I. B.; Veprintsev, D. J.

10.1101/2021.08.09.455709 — molecular biology — Posted on 2022-02-25

457 Brain structure, phenotypic and genetic correlates of reading abilities

Carrion-Castillo, A.; Paz-Alonso, P. M.; Carreiras, M.

10.1101/2022.02.24.481767 — neuroscience — Posted on 2022-02-25

458 The Eucalyptus grandis chloroplast proteome: leaf development and seasonal variations

Baldassi, A.; Balbuena, T.

10.1101/2022.02.24.481842 — plant biology — Posted on 2022-02-24

459 Phenotypic and transcriptional response of Daphnia pulicaria to the combined effects of temperature and predation

Oliver, A.; Cavalheri, H. B.; Lima, T. G.; Jones, N. T.; Podell, S.; Zarate, D.; Allen, E.; Burton, R. S.; Shurin, J. B.

10.1101/2022.02.24.481768 — ecology — Posted on 2022-02-24

460 Population Dynamics and Resource Availability Drive Seasonal Shifts in the Consumptive and Competitive Impacts of Introduced House Mice (Mus musculus) on an Island Ecosystem

Polito, M. J.; Robinson, B.; Warzybok, P.; Bradley, R. W.

10.1101/2022.02.23.481645 — ecology — Posted on 2022-02-24

461 Epstein-Barr virus infection promotes Th1-mediated disease in a humanized immune mouse model of multiple sclerosis

Allanach, J. R.; Hardman, B. K.; Fettig, N. M.; Fan, V.; Rosen, A. R.; Shanina, I.; Vorobeychik, G.; Osborne, L. C.; Horwitz, M. S.

10.1101/2022.02.23.481716 — immunology — Posted on 2022-02-24

462 Chloride ion evokes taste sensation by binding to the extracellular ligand-binding domain of sweet/umami taste receptors

Atsumi, N.; Yasumatsu, K.; Takashina, Y.; Ito, C.; Yasui, N.; Yamashita, A.

10.1101/2022.02.23.481615 — biophysics — Posted on 2022-02-24

463 Three-dimensional cilia structures from animals' closest unicellular relatives, the Choanoflagellates

Pinskey, J. M.; Lagisetty, A.; Gui, L.; Phan, N.; Reetz, E.; Fu, G.; Nicastro, D.

10.1101/2022.02.24.481817 — cell biology — Posted on 2022-02-24

464 Saliva metabolome alterations after acute stress

Morgan, L.; Birkler, R. I. D.; Shaham-Niv, S.; Dong, Y.; Wachsman, T.; Carmi, L.; Yakobson, B.; Adler-Abramovich, L.; Cohen, H.; Zohar, J.; Bateson, M.; Gazit, E.

10.1101/2022.02.24.480641 — molecular biology — Posted on 2022-02-24

465 ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

Weiner, A. I.; Zhao, G.; Zayas, H. M.; Holcomb, N. P.; Adams-Tzivelekidis, S.; Wong, J.; Gentile, M. E.; Palashikar, G.; Quansah, K.; Vaughan, A. E.

10.1101/2022.02.23.481695 — molecular biology — Posted on 2022-02-24

466 Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

Zhang, M.; Kennedy, M.; DeLeon, O.; Bissell, J.; Trigodet, F.; Lolans, K.; Temelkova, S.; Carroll, K. T.; Fiebig, A.; Deutschbauer, A. M.; Sidebottom, A. M.; Henry, C. S.; Rice, P. A.; Bergelson, J.; Chang, E.

10.1101/2022.02.23.481734 — microbiology — Posted on 2022-02-24

467 Targetome analysis of malaria sporozoite transcription factor AP2-Sp reveals its role as a master regulator

yuda, m.; kaneko, i.; murata, y.; Iwanaga, S.; nishi, t.

10.1101/2022.02.23.481739 — microbiology — Posted on 2022-02-24

468 The ankyrin repeat protein RARP-1 is a periplasmic factor that supports Rickettsia parkeri growth and host cell invasion

Sanderlin, A. G.; Hanna, R. E.; Lamason, R. L.

10.1101/2022.02.23.481736 — microbiology — Posted on 2022-02-24

469 Plasmodium GPI-Anchored Micronemal Antigen is essential for parasite transmission through the mosquito host

Jennison, C.; Gibson, J. M.; Hertoghs, N.; Dankwa, D. A.; Kumar, S.; Abatiyow, B. A.; Naung, M.; Minkah, N. K.; Swearingen, K. E.; Moritz, R. L.; Barry, A. E.; Kappe, S. H. I.; Vaughan, A. M.

10.1101/2022.02.24.481744 — microbiology — Posted on 2022-02-24

470 Time-course of host cell transcription during the HTLV-1 transcriptional burst

Kiik, H.; Ramanayake, S.; Miura, M.; Tanaka, Y.; Melamed, A.; Bangham, C. R. M.

10.1101/2022.02.24.481745 — microbiology — Posted on 2022-02-24

471 Multiple scenarios for sexual crosses in the fungal pathogen Zymoseptoria tritici on wheat residues: potential consequences for virulence gene transmission

Orellana-Torrejon, C.; Vidal, T.; Gazeau, G.; Boixel, A.-L.; Gelisse, S.; Lageyre, J.; Saint-Jean, S.; Suffert, F.

10.1101/2022.02.24.481803 — microbiology — Posted on 2022-02-24

472 A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein

Huang, J.; Miller, R.; Mousa, J. J.

10.1101/2022.02.24.481832 — immunology — Posted on 2022-02-24

473 The inhibitory effect of EGCG-AgNP-lysozyme bioconjugates on biofilm formation

Meesaragandla, B.; Hayet, S.; Fine, T.; Janke, U.; chai, l.; Delcea, M.

10.1101/2022.02.23.481602 — biophysics — Posted on 2022-02-24

474 Sequence-directed RNA remodeling within a topologically complex RNP substrate

Cruz Ruiz, V.; Sekulski, K.; Peddada, N.; Sailer, C.; Balasubramanian, S.; Weirich, C.; Stengel, F.; Erzberger, J. P.

10.1101/2022.02.24.481786 — biophysics — Posted on 2022-02-24

475 Chlamydomonas mutant hpm91 lacking PGR5 is a scalable and valuable strain for algal hydrogen (H2) production

Liu, P.; Ye, D.-M.; Chen, M.; Zhang, J.; Huang, X.-H.; Shen, L.-L.; Xia, K.-K.; Xu, X.-J.; Xu, Y.-C.; Guo, Y.-L.; Wang, Y.-C.; Huang, F.

10.1101/2022.02.23.481610 — biochemistry — Posted on 2022-02-24

476 Diagnostic Ion Data Analysis Reduction (DIDAR) allows rapid quality control analysis and filtering of multiplexed single cell proteomics data

Jenkins, C. J.; Orsburn, B. C.

10.1101/2022.02.22.481489 — biochemistry — Posted on 2022-02-24

477 Accurate and simple FXN-GAA repeats (Friedreich ataxia loci) estimation by long read targeted sequencing.

Sharma, P.; Uppilli, B.; Ahmad, I.; Sahni, S.; Faruq, M.

10.1101/2022.02.24.481841 — genetics — Posted on 2022-02-24

478 Evolution of bacterial persistence to antibiotics during a 50,000-generation experiment in an antibiotic-free environment.

Mathe-Hubert, H.; Amia, R.; Martin, M.; Gaffe, J.; Schneider, D.

10.1101/2022.02.24.481834 — evolutionary biology — Posted on 2022-02-24

479 Plasma membrane protrusions mediate host cell-cell fusion induced by Burkholderia thailandensis

Kostow, N.; Welch, M.

10.1101/2022.02.24.481536 — cell biology — Posted on 2022-02-24

480 A central protein complex essential for Invasionin Toxoplasma gondii

Singer, M.; Simon, K.; Forne, I.; Meissner, M.

10.1101/2022.02.24.481622 — cell biology — Posted on 2022-02-24

481 Identification of cytoplasmic chaperone networks relevant for respiratory syncytial virus replication

Latorre, V.; Geller, R.

10.1101/2022.02.23.481726 — microbiology — Posted on 2022-02-24

482 Bacterial metatranscriptomes in wastewater can differentiate virally infected human populations

Salido, R. A.; Martino, C.; Karthikeyan, S.; Huang, S.; Rahman, G.; Gonzalez, A.; Zaramela, L. S.; Beck, K. L.; Bhute, S.; Cantrell, K.; Carrieri, A. P.; Farmer, S.; Haiminen, N.; Humphrey, G.; Kim, H.-C.; Parida, L.; Richter, R. A.; Vazquez-Baeza, Y.; Zengler, K.; Swafford, A.; Bartko, A.; Knight, R.

10.1101/2022.02.23.481658 — microbiology — Posted on 2022-02-24

483 Screening and Identification of Azo Dye Decolourizers from Mangrove Rhizospheric soil

Modi, A.; Singh, S.; Patki, J.; Padmadas, N.

10.1101/2022.02.24.481723 — microbiology — Posted on 2022-02-24

484 Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants

Mykytyn, A. Z.; Rissmann, M.; Kok, A.; Rosu, M.; Schipper, D.; Breugem, T. I.; van den Doel, P. B.; Chandler, F.; Bestebroer, T.; de Wit, M.; van Royen, M. E.; Molenkamp, R.; Oude Munnink, B.; de Vries, R. D.; GeurtsvanKessel, C.; Smith, D. J.; Koopmans, M.; Rockx, B.; Lamers, M. M.; Fouchier, R.; Haagmans, B.

10.1101/2022.02.23.481644 — microbiology — Posted on 2022-02-24

485 Methionine Metabolism Controls the B-cell EBV Epigenome and Viral Latency

Guo, R.; Liang, J. H.; Zhang, Y.; Lutchenkov, M.; Li, Z.; Wang, Y.; Trujillo-Alonso, V.; Puri, R.; Giulino-Roth, L.; Gewurz, B.

10.1101/2022.02.24.481783 — microbiology — Posted on 2022-02-24

486 Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

Lei, R.; Tan, T. J. C.; Garcia, A. H.; Wang, Y.; Teo, C.; Gopan, G.; Tavakoli Dargani, Z.; Teo, Q. W.; Graham, C. S.; Nair, S. K.; Wu, N. C.

10.1101/2022.02.24.481718 — microbiology — Posted on 2022-02-24

487 Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts

Gonzalez-Davila, P.; Schwalbe, M.; Danewalia, A.; Wardenaar, R.; Dalile, B.; Verbeke, K.; Mahata, S. K.; El Aidy, S.

10.1101/2022.02.24.481402 — microbiology — Posted on 2022-02-24

488 Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2

Novikov, M.; Hasanpourghadi, M.; Ambrose, R.; Chekaoui, A.; Newman, D.; Giles-Davis, W.; Zhou, X.; Xiang, Z.; Ertl, H. C. J.

10.1101/2022.02.23.481620 — immunology — Posted on 2022-02-24

489 A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

Huisman, B. D.; Dai, Z.; Gifford, D. K.; Birnbaum, M. E.

10.1101/2022.02.22.480950 — immunology — Posted on 2022-02-24

490 Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

Pearson, J.; Wessler, T.; Chen, A.; Boucher, R. C.; Freeman, R.; Lai, S. K.; Pickles, R.; Forest, M. G.

10.1101/2022.02.23.481492 — immunology — Posted on 2022-02-24

491 LUBAC is required for RIG-I sensing of RNA viruses

Teague, H. C.; Lefevre, C.; Rieser, E.; de Miguel, D.; Patricio, D.; Oliveira, M.; Mansur, D. S.; Irigoyen, N.; Walczak, H.; Ferguson, B. J.

10.1101/2022.02.24.481814 — immunology — Posted on 2022-02-24

492 Metabolic Engineering of Oleaginous Yeast Rhodotorula toruloides for Overproduction of Triacetic Acid Lactone

Cao, M.; Tran, V. G.; Qin, J.; Olson, A.; Xie, D.; Huang, C.; Schultz, J. C.; Zhao, H.

10.1101/2022.02.24.481788 — synthetic biology — Posted on 2022-02-24

493 EARLY AND MID-GESTATION ZIKA VIRUS (ZIKV) INFECTION IN THE OLIVE BABOON (PAPIO ANUBIS) LEADS TO FETAL CNS PATHOLOGY BY TERM GESTATION

Gurung, S.; Reuter, D.; Norris, A.; Dubois, M.; Maxted, M.; Singleton, K.; Castillo-Castrejon, M.; Papin, J. F.; Myers, D. A.

10.1101/2022.02.23.481575 — pathology — Posted on 2022-02-24

494 Trunk neural crest migratory position and asymmetric division predict terminal differentiation

Alhashem, Z.; Camargo-Sosa, K.; Kelsh, R. N.; Linker, C.

10.1101/2022.02.23.481590 — developmental biology — Posted on 2022-02-24

495 Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes

Martin, K.; Ravisankar, P.; Beerens, M.; MacCrae, C.; Waxman, J.

10.1101/2022.02.24.481762 — developmental biology — Posted on 2022-02-24

496 Epidermal basal domains organization highlights skin robustness to environmental exposure

Ghuwalewala, S.; Lee, S. A.; Jiang, K.; Baidya, J.; Chovatiya, G.; Kaur, P.; Shalloway, D.; Tumbar, T.

10.1101/2022.02.23.481662 — developmental biology — Posted on 2022-02-24

497 Optimization of Whole Mount RNA multiplexed in situ Hybridization Chain Reaction with Immunohistochemistry, Clearing and Imaging to visualize octopus neurogenesis

Elagoz, A. M.; Styfhals, R.; Maccuro, S.; Masin, L.; Moons, L.; Seuntjens, E.

10.1101/2022.02.24.481749 — developmental biology — Posted on 2022-02-24

498 Myopia alters the structural organization of the retinal astrocyte template, associated vasculature and ganglion layer thickness.

Lin, C. R.; Toychiev, A.; Slavi, N.; Srinivas, M.; Ablordeppey, R. K.; Benavente-Perez, A.

10.1101/2022.02.22.481546 — developmental biology — Posted on 2022-02-24

499 AN IMAGING FLOW CYTOMETRY-BASED METHODOLOGY FOR THE ANALYSIS OF SINGLE EXTRACELLULAR VESICLES IN UNPROCESSED HUMAN PLASMA

Woud, W. W.; Pol, E.; Mul, E.; Hoogduijn, M. J.; Baan, C. C.; Boer, K.; Merino, A. M.

10.1101/2022.02.24.481807 — cell biology — Posted on 2022-02-24

500 Induction of tumor-initiating cells and glioma-initiating cells from fetal neural stem cells through p53 genome editing

Ohtsu, N.

10.1101/2022.02.24.481795 — cell biology — Posted on 2022-02-24

501 AIMP1-derived peptide secreted from hair follicle stem cells activates dermal papilla cells to promote hair growth

Kim, Y.; Lee, H.; Kim, D.; Bak, S. S.; Yoon, I.; Paus, R.; Cho, S.; Jeong, S. J.; Jeon, Y.; Park, M. C.; Oh, J. W.; Park, J. M.; Kim, S. B.; Sung, Y. K.; Kim, S.

10.1101/2022.02.24.481761 — cell biology — Posted on 2022-02-24

502 Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

Chen, C.; Saville, J. W.; Marti, M. M.; Schaefer, A.; Cheng, M. H.; Mannar, D.; Zhu, X.; Berezuk, A. M.; Banerjee, A.; Sobolewski, M. D.; Kim, A.; Treat, B. R.; Da Silva Castanha, P. M.; Enick, N.; McCormick, K. D.; Liu, X.; Adams, C.; Hines, M. G.; Sun, Z.; Chen, W.; Jacobs, J. L.; Barratt-Boyes, S. M.; Mellors, J. W.; Baric, R. S.; Bahar, I.; Dimitrov, D. S.; Subramaniam, S.; Martinez, D. R.; Li, W.

10.1101/2022.02.18.481058 — immunology — Posted on 2022-02-24

503 Face familiarity detection with complex synapses

Ji-An, L.; Stefanini, F.; Benna, M. K.; Fusi, S.

10.1101/854059 — neuroscience — Posted on 2022-02-24

504 Graded spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of the mouse spinal cord

Johnson, E.; Clark, M.; Oncul, M.; MacLean, C.; Deuchars, J.; Deuchars, S. A.; Johnston, J.

10.1101/2020.09.18.303347 — neuroscience — Posted on 2022-02-24

505 Rabbit hindlimb kinematics and ground contact pressure during the stance phase of hopping gait

Hall, P. T.; Stubbs, C.; Anderson, D. E.; Greenacre, C. B.; Crouch, D. L.

10.1101/2022.02.02.478798 — systems biology — Posted on 2022-02-24

506 Microcompartment assembly around multicomponent fluid cargoes

Tsidilkovski, L.; Hagan, M. F.

10.1101/2022.02.23.481520 — biophysics — Posted on 2022-02-24

507 Structural basis for Nirmatrelvir in vitro efficacy against SARS-CoV-2 variants

Greasley, S. E.; Noell, S.; Plotnikova, O.; Ferre, R. A.; Liu, W.; Bolanos, B.; Fennell, K. F.; Nicki, J.; Craig, T.; Zhu, Y.; Stewart, A. E.; Steppan, C. M.

10.1101/2022.01.17.476556 — biochemistry — Posted on 2022-02-24

508 Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation

Vandiver, A. R.; Pielstick, B.; Gilpatrick, T.; Hoang, A.; Vernon, H.; Wanagat, J.; Timp, W.

10.1101/2022.02.23.480720 — genomics — Posted on 2022-02-24

509 HREM, RNAseq and cell-cycle analyses reveal the role of the G2/M-regulatory protein, Wee1, on the survivability of chicken embryos during diapause.

Pokhrel, N.; Genin, O.; Sela-Donenfeld, D.; Cinnamon, Y.

10.1101/2022.02.23.481599 — evolutionary biology — Posted on 2022-02-24

510 Resolving tricky nodes in the tree of life through amino acid recoding

Giacomelli, M.; Rossi, M. E.; Lozano-Fernandez, J.; Feuda, R.; Pisani, D.

10.1101/2022.02.24.479670 — evolutionary biology — Posted on 2022-02-24

511 Functional stemness-related genes revealed by single-cell profiling of naïve and stimulated human CD34+ cells from CB and mPB

Dong, G.; Xu, X.; Ouyang, W.; Gu, Y.; Li, J.; Liu, T.; Zeng, X.; Liu, C.; Zou, H.; Wang, S.; Sun, H.

10.1101/2022.02.23.481626 — cell biology — Posted on 2022-02-24

512 Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation and cytokine responses in COVID-19

Robertson, S.; Bedard, O.; McNally, K.; Lewis, M.; Clancy, C.; Shaia, C.; Broeckel, R.; Chiramel, A.; Sturdevant, G.; Forte, E.; Preuss, C.; Baker, C.; Harder, J.; Brunton, C.; Munger, S. C.; Sturdevant, D.; Martens, C.; Holland, S.; Rosenthal, N.; Best, S.

10.1101/2021.09.17.460664 — microbiology — Posted on 2022-02-24

513 Neutralization of SARS-CoV-2 Omicron BA.2 by Therapeutic Monoclonal Antibodies

Zhou, H.; Tada, T.; Dcosta, B. M.; Landau, N. R.

10.1101/2022.02.15.480166 — immunology — Posted on 2022-02-24

514 Single-cell analysis reveals the range of transcriptional states of circulating human neutrophils

Wigerblad, G.; Cao, Q.; Brooks, S.; Naz, F.; Gadkari, M.; Jiang, K.; Gupta, S.; O'Neil, L.; Dell'Orso, S.; Kaplan, M. J.; Franco, L. M.

10.1101/2022.02.22.481522 — immunology — Posted on 2022-02-24

515 Quantifying the phenotypic information in mRNA abundance

Maltz, E. W.; Wollman, R.

10.1101/2022.02.23.481668 — systems biology — Posted on 2022-02-24

516 Trends in Arabidopsis Research post genome sequencing- A Scientometric study

Kumar, S.; Kushwaha, A. K.; R, T.; M, B.; P, K.

10.1101/2022.02.22.481563 — plant biology — Posted on 2022-02-24

517 Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM

Matusovsky, O. S.; Mannson, A.; Rassier, D. E.

10.1101/2022.02.24.481751 — biophysics — Posted on 2022-02-24

518 Spinning Disk Multifocal Microscopy for Dynamic Arbitrarily Shaped Surface Imaging at Centimetre Scale and Micrometre Resolution

Xie, H.; Han, X.; Xiao, G.; Xu, H.; Zhang, Y.; Zhang, G.; Li, Q.; He, J.; Zhu, D.; Yu, X.; Dai, Q.

10.1101/2022.02.22.481397 — bioengineering — Posted on 2022-02-24

519 Actin turnover protects the cytokinetic contractile ring from structural instability

McDargh, Z. A.; Zhu, T.; Zhu, H.; O'Shaughnessy, B.

10.1101/2022.02.23.481727 — cell biology — Posted on 2022-02-24

520 ATPase activity of DFCP1 controls selective autophagy

Nähse, V.; Raiborg, C.; Tan, K. W.; Mørk, S.; Torgersen, M. L.; Wenzel, E. M.; Nager, M.; Salo, V. T.; Johansen, T.; Ikonen, E.; Schink, K. O.; Stenmark, H.

10.1101/2022.02.24.481614 — cell biology — Posted on 2022-02-24

521 Three membrane fusion pore families determine the pathways of pore dilation

Su, R.; Wang, S.; McDargh, Z. A.; O'Shaughnessy, B.

10.1101/2022.02.23.481713 — biophysics — Posted on 2022-02-24

522 Benchmarking of deep learning algorithms for 3D instance segmentation of confocal image datasets

Kar, A.; Petit, M.; Refahi, Y.; Cerutti, G.; Godin, C.; Traas, J.

10.1101/2021.06.09.447748 — bioinformatics — Posted on 2022-02-24

523 PanGraph: scalable bacterial pan-genome graph construction

Noll, N.; Molari, M.; Neher, R.

10.1101/2022.02.24.481757 — bioinformatics — Posted on 2022-02-24

524 Combining SLA 3D printing and soft lithography for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

Hagemann, C.; Bailey, M. C. D.; Khokhar, N.; Lionello, V. M.; Suklai, P.; Moreno-Gonzalez, C.; O'Toole, K.; Konstantinou, G.; Giagnorio, E.; Bergholt, M.; Imbert, A.; Tedesco, F. S.; Serio, A.

10.1101/2022.02.22.481424 — bioengineering — Posted on 2022-02-24

525 QTL analysis reveals an oligogenic architecture of a rapidly adapting trait during the European invasion of common ragweed

Prapas, D.; Scalone, R.; Lee, J.; Nurkowski, K.; Bou-assi, S.; Rieseberg, L. H.; Battlay, P.; Hodgins, K. A.

10.1101/2022.02.24.481758 — evolutionary biology — Posted on 2022-02-24

526 Complex effects of chytrid parasites on the growth of the cyanobacterium Planktothrix rubescens across interacting temperature and light gradients

Wierenga, J.; Thomas, M. K.; Ranjan, R.; Ibelings, B. W.

10.1101/2022.02.24.481659 — ecology — Posted on 2022-02-24

527 Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring

Martins, C. S.; Taveneau, C.; Castro-Linares, G.; Baibakov, M.; Buzhinsky, N.; Eroles, M.; Milanovic, V.; Iv, F.; Bouillard, L.; Llewellyn, A.; Gomes, M.; Belhabib, M.; Kuzmic, M.; Verdier-Pinard, P.; Lee, S.; Badache, A.; Kumar, S.; Chandre, C.; Brasselet, S.; Rico, F.; Rossier, O.; Koenderink, G. H.; Wenger, J.; Cabantous, S.; Mavrakis, M.

10.1101/2022.02.23.481653 — cell biology — Posted on 2022-02-24

528 Potent Neutralizing Activity of Polyclonal Equine Antibodies against Omicron SARS-CoV-2

Luczkowiak, J.; Radreau, P.; Nguyen, L.; Labiod, N.; Lasala, F.; Herbreteau, C. H.; Delgado, R.

10.1101/2022.02.21.481341 — microbiology — Posted on 2022-02-24

529 Neutral sphingomyelinase 1 regulates cellular fitness at the level of ER stress and cell cycle

Choezom, D.; Gross, J. C.

10.1101/2022.02.23.481585 — cell biology — Posted on 2022-02-24

530 Sporulation activated via σW protects Bacillus from a Tse1 peptidoglycan hydrolase T6SS effector

Perez-Lorente, A. I.; Molina-Santiago, C.; de Vicente, A.; Romero Hinojosa, D. F.

10.1101/2022.02.23.481616 — microbiology — Posted on 2022-02-24

531 Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint

Chaplain, M. A.; Eftimie, R.; Macfarlane, F.

10.1101/2021.09.02.458714 — immunology — Posted on 2022-02-24

532 Fuzzy Supertertiary Interactions within PSD-95 Enable Ligand Binding

Bowen, M. E.; Sanabria, H.; Ding, F.; Seidel, C. A.; Hao, Y.; Zhang, C.; Kubiak, j.; Wu, F.; Welcome, F. S.; Basak, S.; Saikia, N.; Hamilton, G. L.

10.1101/2022.02.23.481591 — biophysics — Posted on 2022-02-24

533 Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of Flaviviridae.

Bamford, C. G. G.; Souza, W. M.; Parry, R.; Gifford, R. J.

10.1101/2021.09.19.460981 — evolutionary biology — Posted on 2022-02-24

534 Neural defensive circuits underlie helping under threat in humans

Vieira, J. B.; Olsson, A.

10.1101/2021.12.17.473167 — neuroscience — Posted on 2022-02-24

535 Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation

Brandhofer, M.; Hoffmann, A.; Blanchet, X.; Siminkovitch, E.; Rohlfing, A.-K.; El Bounkari, O.; Nestele, J. A.; Bild, A.; Kontos, C.; Hille, K.; Rohde, V.; Froehlich, A.; Golemi, J.; Goekce, O.; Krammer, C. M.; Scheiermann, P.; Tsilimparis, N.; Kempf, W. E.; Maegdefessel, L.; Megens, R. T. A.; Ippel, H.; Koenen, R. R.; Mayo, K.; Gawaz, M.; Kapurniotu, A.; Weber, C.; von Hundelshausen, P.; Bernhagen, J.

10.1101/2021.11.26.470090 — immunology — Posted on 2022-02-24

536 Probing the proton release by Photosystem II in the S1 to S2 high-spin transition

Boussac, A.; sugiura, m.; sellés, j.

10.1101/2022.01.19.476895 — biochemistry — Posted on 2022-02-24

537 Social play is critical for the development of prefrontal inhibitory synapses and cognitive flexibility in rats

Bijlsma, A.; Omrani, A.; Spoelder, M.; Verharen, J. P. H.; Bauer, L.; Cornelis, C.; de Zwart, B.; van Dorland, R.; Vanderschuren, L. J. M. J.; Wierenga, C. J.

10.1101/2020.05.01.070540 — neuroscience — Posted on 2022-02-24

538 Regulation of the PKD2 channel function by TACAN

Liu, X.; Zhang, R.; Fatehi, M.; Wang, Y.; Long, W.; Tian, R.; Deng, X.; Weng, Z.; Xu, Q.; Light, P. E.; Tang, J.; Chen, X.-Z.

10.1101/2021.12.23.473878 — physiology — Posted on 2022-02-24

539 Early identification of cooperative fragments for protein-protein interaction stabilization

de Vink, P. J.; Cossar, P. J.; Somsen, B. A.; Ottmann, C. O.; Brunsveld, L.

10.1101/2022.02.23.481635 — biochemistry — Posted on 2022-02-24

540 Phylogenetic Network Dissimilarity Measures That Take Branch Lengths Into Account

Yakici, B. A.; Ogilvie, H. A.; Nakhleh, L.

10.1101/2022.02.22.481483 — evolutionary biology — Posted on 2022-02-24

541 Recombination smooths the time-signal disrupted by latency in within-host HIV phylogenies

Castro, L. A.; Leitner, T.; Romero-Severson, E.

10.1101/2022.02.22.481498 — evolutionary biology — Posted on 2022-02-24

542 Masculinization of the X-chromosome in aphid soma and gonads

Jaquiery, J.; Simon, J.-C.; Robin, S.; Richard, G.; Peccoud, J.; Boulain, H.; Legeai, F.; Tanguy, S.; Prunier-Leterme, N.; Letrionnaire, G.

10.1101/2021.08.13.453080 — evolutionary biology — Posted on 2022-02-24

543 Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen

Flamant, F.; Guyot, R.

10.1101/2022.02.23.481571 — molecular biology — Posted on 2022-02-24

544 A Neural Model of Task Compositionality with Natural Language Instructions

Riveland, R.; Pouget, A.

10.1101/2022.02.22.481293 — neuroscience — Posted on 2022-02-24

545 The structural context of PTMs at a proteome wide scale

Bludau, I.; Willems, S.; Zeng, W.-F.; Strauss, M. T.; Hansen, F. M.; Tanzer, M. C.; Karayel, O.; Schulman, B. A.; Mann, M.

10.1101/2022.02.23.481596 — systems biology — Posted on 2022-02-24

546 Spatiotemporal growth pattern during plant nutation implies fast dynamics for cell wall mechanics and chemistry: a multiscale study in Averrhoa carambola

Riviere, M.; Peaucelle, A.; Derr, J.; Douady, S.

10.1101/2022.02.22.481493 — biophysics — Posted on 2022-02-24

547 SEQUIN: rapid and reproducible analysis of RNA-seq data in R/Shiny

Weber, C.; Hirst, M. B.; Ernest, B.; Baskir, H.; Tristan, C. A.; Chu, P.-H.; Singec, I.

10.1101/2022.02.23.481646 — bioinformatics — Posted on 2022-02-24

548 mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts

Furtado, D.; Cortez-Jugo, C.; Hung, Y. H.; Bush, A. I.; Caruso, F.

10.1101/2022.02.21.479058 — bioengineering — Posted on 2022-02-24

549 Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

Seth, A.; Landau, M.; Shevchenko, A.; Traikov, S.; Schultz, A.; Elsabbagh, S.; Schultz, J. E.

10.1101/2022.02.23.481604 — biochemistry — Posted on 2022-02-24

550 Neuromuscular embodiment of feedback control elements in Drosophila flight

Whitehead, S. C.; Leone, S.; Lindsay, T.; Meiselman, M. R.; Cowan, N.; Dickinson, M. H.; Yapici, N.; Stern, D.; Shirangi, T.; Cohen, I.

10.1101/2022.02.22.481344 — animal behavior and cognition — Posted on 2022-02-24

551 Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Kirouac, G. J.; Li, S.; Li, S.

10.1101/2022.02.23.481069 — animal behavior and cognition — Posted on 2022-02-24

552 Effects of the social environment on movement-integrated habitat selection

Webber, Q. M. R.; Prokopenko, C. M.; Kingdon, K. A.; Turner, J. W.; Vander Wal, E.

10.1101/2021.02.11.430740 — animal behavior and cognition — Posted on 2022-02-24

553 High nucleotide similarity of three Copia lineage LTR retrotransposons among plant genomes

Orozco-Arias, S.; Dupeyron, M.; Gutierrez-Duque, D.; Tabares-Soto, R.; Guyot, r.

10.1101/2022.02.23.481133 — genomics — Posted on 2022-02-24

554 PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression

Lakhia, R.; Ramalingam, H.; Chang, C.-M.; Cobo-Stark, P.; Biggers, L.; Flaten, A.; Alvarez, J.; Valencia, T.; Wallace, D. P.; Lee, E.; Patel, V.

10.1101/2022.02.23.479396 — genetics — Posted on 2022-02-24

555 On the hybrid origin of the C2 Salsola divaricata agg. (Amaranthaceae) from C3 and C4 parental lineages

Tefarikis, D. T.; Morales-Briones, D. F.; Yang, Y.; Edwards, G.; Kadereit, G.

10.1101/2021.09.23.461503 — evolutionary biology — Posted on 2022-02-24

556 Admixture of evolutionary rates across a hybrid zone

Xiong, T.; Li, X.; Yago, M.; Mallet, J.

10.1101/2021.09.27.461223 — evolutionary biology — Posted on 2022-02-24

557 Using dilution grazing assays to measure size fractionated phytoplankton mortality rates across the freshwater-to-marine continuum

Barnard, M. A.; Paerl, H. W.

10.1101/2022.02.23.481667 — ecology — Posted on 2022-02-24

558 Vitronectin mediates survival of human WJ-MSCs under inflammatory temperature stress via cell cycle arrest.

Goyal, U.; TA, M.

10.1101/2022.02.23.481475 — cell biology — Posted on 2022-02-24

559 222-nm far UVC exposure results in DNA damage and transcriptional changes to mammalian cells.

Ong, Q.; Wee, W.; Dela Cruz, J.; Teo, J. W. R.; Han, W.

10.1101/2022.02.22.481471 — cell biology — Posted on 2022-02-24

560 Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosis

Horta, C.; Tavares, A.; Oliveira, R. A.

10.1101/2022.02.23.481572 — cell biology — Posted on 2022-02-24

561 Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

Krasniewski, L. K.; Chakraborty, P.; Cui, C.-Y.; Mazan-Mamczarz, K.; Dunn, C.; Piao, Y.; Fan, J.; Shi, C.; Wallace, T.; Nguyen, C.; Rathbun, I. A.; Munk, R.; Tsitsipatis, D.; De, S.; Sen, P.; Ferrucci, L.; M Gorospe, M.

10.1101/2022.02.23.481581 — cell biology — Posted on 2022-02-24

562 Melanin Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

Kwon, Y.-S.; Zheng, M.; Zhang, A. Y.; Han, Z.

10.1101/2022.02.22.481315 — molecular biology — Posted on 2022-02-24

563 Metamorphism of catalytic domain controls transposition in Tn3 family transposases

Shkumatov, A. V.; Aryanpour, N.; Oger, C. A.; Goossens, G.; Hallet, B. F.; Efremov, R. G.

10.1101/2022.02.23.481423 — molecular biology — Posted on 2022-02-24

564 Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

Rosenke, K.; Okumura, A.; Lewis, M. C.; Feldmann, F.; Meade-White, K.; Bohler, W. F.; Griffin, A.; Rosenke, R.; Shaia, C.; Jarvis, M.; Feldmann, H.

10.1101/2022.02.22.481491 — microbiology — Posted on 2022-02-24

565 Ivermectin does not protect against SARS-CoV-2 infection in the Syrian hamster model

Foo, C. S.-Y.; Abdelnabi, R.; Vangeel, L.; De Jonghe, S.; Jochmans, D.; Weynand, B.; Neyts, J.

10.1101/2022.02.22.481472 — microbiology — Posted on 2022-02-24

566 A novel lipase with dual localisation in Trypanosoma brucei

Monic, S.; Lamy, A.; Magali, T.; Bizarra-Rebelo, T.; Bringaud, F.; Smith, T. K.; Figueiredo, L. M.; Riviere, L.

10.1101/2022.02.23.481587 — microbiology — Posted on 2022-02-24

567 The extracellular sialidase NEU3 induces neutrophil priming

Kirolos, S. A.; Gomer, R. H.

10.1101/2022.02.23.481673 — immunology — Posted on 2022-02-24

568 Fate-resolved gene regulatory signatures of individual B lymphocytes in the early stages of Epstein-Barr Virus infection

SoRelle, E. D.; Dai, J.; Reinoso-Vizcaino, N. M.; Barry, A. P.; Chan, C.; Luftig, M. A.

10.1101/2022.02.23.481342 — immunology — Posted on 2022-02-24

569 SARS-CoV-2 peptide vaccine elicits T-cell responses in mice but does not protect against infection or disease

Baxter, V. K.; Anderson, E. J.; Taft-Benz, S. A.; Olsen, K. S.; Sambade, M.; Gentry, K. M.; Beck, W. A.; Garness, J.; Woods, A.; Fini, M.; Carpenter, B.; Smith, C. C.; Heise, M. T.; Vincent, B. G.; Rubinsteyn, A.

10.1101/2022.02.22.481499 — immunology — Posted on 2022-02-24

570 Antisense modulation of IL7R splicing to control sIL7R expression in human CD4 T cells

Galarza-Munoz, G.; Kennedy-Boone, D.; Schott, G.; Bradrick, S. S.; Garcia-Blanco, M. A.

10.1101/2022.02.22.481529 — immunology — Posted on 2022-02-24

571 Odorant receptor orthologues in conifer-feeding beetles display conserved responses to ecologically relevant odors

Roberts, R. E.; Biswas, T.; Yuvaraj, J. K.; Grosse-Wilde, E.; Powell, D.; Hansson, B. S.; Lofstedt, C.; Andersson, M. N.

10.1101/2022.02.22.481428 — neuroscience — Posted on 2022-02-24

572 Theta-phase connectivity between medial prefrontal and posterior areas underlies novel instructions implementation

Formica, S.; Gonzalez-Garcia, C.; Senoussi, M.; Marinazzo, D.; Brass, M.

10.1101/2022.02.23.481594 — neuroscience — Posted on 2022-02-24

573 Regional and cell type-specific afferent and efferent projections of the mouse claustrum

Wang, Q.; Wang, Y.; Xie, P.; Kuo, H.-C.; Hirokawa, K. E.; Naeemi, M.; Yao, S.; Ouellette, B.; Mallory, M.; Lesnar, P.; Kuang, X.; Li, Y.; Ye, M.; Chen, C.; Xiong, W.; Ahmadinia, L.; El-Hifnawi, L.; Cetin, A.; Harris, J. A.; Zeng, H.; Koch, C.

10.1101/2022.02.23.481555 — neuroscience — Posted on 2022-02-24

574 A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray

Iwasaki, M.; Lefevre, A.; Althammer, F.; Lapies, O.; Hilfiger, L.; Kerspern, D.; Melchior, M.; Kueppers, S.; Krablicher, Q.; Patwell, R.; Herpertz, S.; Ditzen, B.; Schoenig, K.; Bartsch, D.; Sterm, J. E.; Darbon, P.; Grinevich, V.; Charlet, A.

10.1101/2022.02.23.481531 — neuroscience — Posted on 2022-02-24

575 Temporal continuity shapes visual responses of macaque face patch neurons

Russ, B. E.; Koyano, K. W.; Day-Cooney, J.; Perwez, N.; Leopold, D. A.

10.1101/2022.02.22.481478 — neuroscience — Posted on 2022-02-24

576 Somatostatin Neurons in the Bed Nucleus of the Stria Terminalis Play a Sex-Dependent Role in Binge Drinking

Suresh Nair, M.; Dao, N. C.; Lopez Melean, D.; Griffith, K. R.; Starnes, W. D.; Moyer, J. B.; Sicher, A. R.; Brockway, D. F.; Meeks, K. D.; Crowley, N. A.

10.1101/2022.02.23.481479 — neuroscience — Posted on 2022-02-24

577 Detection of functional activity in brain white matter using fiber architecture informed synchrony mapping

Zhao, Y.; Gao, Y.; Zu, Z.; Li, M.; Schilling, K.; Anderson, A.; Gore, J.

10.1101/2022.02.23.481698 — neuroscience — Posted on 2022-02-24

578 PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Foley, K.; Altimimi, H.; Hou, H.; Zhang, Y.; McKee, C.; Papasergi-Scott, M. M.; Yang, H.; Mayer, A.; Ward, N.; MacLean, D. M.; Nairn, A. C.; Stellwagen, D.; Xia, H.

10.1101/2022.02.10.480004 — neuroscience — Posted on 2022-02-24

579 LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

Shimizu, H.; Kodama, M.; Matsumoto, M.; Orba, Y.; Sasaki, M.; Sato, A.; Sawa, H.; Nakayama, K. I.

10.1101/2021.09.25.461785 — systems biology — Posted on 2022-02-23

580 Rank Selection Genetic Algorithm optimises robust parameter estimation for systems biology models

Douilhet, G.; Niranjan, M.; Vallejo, A.; Clayton, K.; Davies, J.; Sirvent, S.; Pople, J.; Ardern-Jones, M. R.; Polak, M. E.

10.1101/2022.02.22.481394 — systems biology — Posted on 2022-02-23

581 EMBED: Essential Microbiome Dynamics, a dimensionality reduction approach for longitudinal microbiome studies

Shahin, M.; Ji, B. W.; Dixit, P. D.

10.1101/2021.03.18.436036 — systems biology — Posted on 2022-02-24

582 Galaxy-SynBioCAD: Automated Pipeline for Synthetic Biology Design and Engineering

Herisson, J.; Duigou, T.; du Lac, M.; Bazi-Kabbaj, K.; Sabeti Azad, M.; Buldum, G.; Telle, O.; El-Moubayed, Y.; Carbonell, P.; Swainston, N.; Zulkower, V.; Kushwaha, M.; Baldwin, G.; Faulon, J.-L.

10.1101/2022.02.23.481618 — synthetic biology — Posted on 2022-02-23

583 A revised view on the evolution of glutamine synthetase isoenzymes in plants

Valderrama-Martin, J. M.; Ortigosa, F.; Avila, C.; Canovas, F. M.; Hirel, B.; Canton, F. R.; Canas, R. A.

10.1101/2021.11.08.467771 — plant biology — Posted on 2022-02-23

584 The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

Barghouth, M.; Jiang, X.; Nagao, M.; Chen, N.; Yang, D.; Ye, Y.; Luan, C.; Gomez, M.; Blom, A. M.; Wollheim, C.; Eliasson, L.; Renstrom, E.; Zhang, E.

10.1101/2022.02.22.481455 — physiology — Posted on 2022-02-23

585 Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling

Chao, D. H. M.; Kirchner, M. K.; Pham, C.; Foppen, E.; Denis, R. G. P.; Castel, J.; Morel, C.; Montalban, E.; Hassouna, R.; Bui, L.-C.; Renault, J.; Mouffle, C.; Garcia-Caceres, C.; Tschop, M. H.; Li, D.; Martin, C.; Stern, J. E.; Luquet, S. H.

10.1101/2022.02.16.480737 — physiology — Posted on 2022-02-24

586 Heat Shock Factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat-shock response

Xu, M.; Lin, L.; Chuang, K.-H.; Ram, B.; Dai, S.; Su, K.-H.; Tang, Z.; Dai, C.

10.1101/2022.02.22.481519 — cancer biology — Posted on 2022-02-23

587 First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer

Haughey, M. J.; Bassolas, A.; Sousa, S.; Baker, A.-M.; Graham, T. A.; Nicosia, V.; Huang, W.

10.1101/2022.02.22.481463 — cancer biology — Posted on 2022-02-24

588 Biophysical fitness landscape of the SARS-CoV-2 Delta variant receptor binding domain

Patrick, C.; Upadhyay, V.; Lucas, A.; Mallela, K.

10.1101/2022.02.21.481311 — biophysics — Posted on 2022-02-23

589 Topologically frustrated dynamics in an uncharged Tetra-PEG gel

Jia, D.; Tsuji, Y.; Shibayama, M.; Muthukumar, M.

10.1101/2022.02.23.481633 — biophysics — Posted on 2022-02-23

590 Frequency dependent growth of bacteria in living materials

Lewis, D.; Gong, T.; Xu, Y.; Tan, C.

10.1101/2022.02.22.481564 — biophysics — Posted on 2022-02-24

591 Effect of an amyloidogenic SARS-COV-2 protein fragment on α-synuclein monomers and fibrils

Jana, A. K.; Lander, C. W.; Chesney, A. D.; Hansmann, U. H. E.

10.1101/2022.02.21.481360 — biophysics — Posted on 2022-02-24

592 The Origin of Conductive-Pulse Sensing Inside a Nanopore and the Role of Electro-Hydrodynamics

Lastra, L.; Nguyen, M.; Farajpour, N.; Freedman, K. J.

10.1101/2020.09.25.310755 — biophysics — Posted on 2022-02-24

593 Omicron and Alpha P680H block SARS-CoV2 spike protein from accessing cholinergic inflammatory pathway via α9-nAChR mitigating the risk of MIS-C

Camacho, C. J.; Santiago, U.

10.1101/2022.02.18.481096 — biophysics — Posted on 2022-02-24

594 Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains

Madanagopal, P.; Muthukumar, H.; Thiruvengadam, K.

10.1101/2022.02.08.479559 — bioinformatics — Posted on 2022-02-23

595 Thermodynamic limitations of metabolic strategies for PHB production from formate and fructose in Cupriavidus necator

Janasch, M.; Crang, N.; Bruch, M.; Asplund-Samuelsson, J.; Gynna, A.; Jahn, M.; Hudson, E. P.

10.1101/2022.02.22.481442 — bioengineering — Posted on 2022-02-23

596 GANscan: continuous scanning microscopy using deep learning deblurring

Fanous, M.; Popescu, G.

10.1101/2022.02.22.481502 — bioengineering — Posted on 2022-02-24

597 Structural and temporal basis for agonism in the α4β2 nicotinic acetylcholine receptor

Oliveira, A. S. F.; Bermudez, I.; Gallagher, T.; Wonnacott, S.; Ciccotti, G.; Sessions, R. B.; Mulholland, A. J.

10.1101/2022.02.23.481608 — biochemistry — Posted on 2022-02-24

598 Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

Siraliev-Perez, E.; Sondek, J.; Temple, B. R. S.; Zhang, Q.; Hajicek, N.; Burke, J. E.; Stariha, J. T.; Hoffmann, R. M.; Jenkins, M. L.

10.1101/2022.02.23.481568 — biochemistry — Posted on 2022-02-24

599 Rats emit unique distress calls in social inequality conditions

Okabe, S.; Takayanagi, Y.; Yoshida, M.; Onaka, T.

10.1101/2022.02.22.481162 — animal behavior and cognition — Posted on 2022-02-24

600 Deep learning-based system for real-time behavior recognition and closed-loop control of behavioral mazes using depth sensing

Geros, A. F.; Cruz, R.; de Chaumont, F.; Cardoso, J. S.; Aguiar, P.

10.1101/2022.02.22.481410 — animal behavior and cognition — Posted on 2022-02-24

601 Confirming Multiplex Q-PCR Use in COVID-19 with Next Generation Sequencing: Strategies for Epidemiological Advantage

Carpenter, R. E.; Tamrakar, V. K.; Chahar, H. S.; Vine, T.; Sharma, R.

10.1101/2022.02.22.481485 — genomics — Posted on 2022-02-23

602 Enrichment of somatic mutations in schizophrenia brain targets prenatally active transcription factor bindings sites

Maury, E. A.; Jones, A.; Seplyarskiy, V.; Rosenbluh, C.; Bae, T.; Wang, Y.; Abyzov, A.; Khoshkoo, S.; Chahine, Y.; Brain Somatic Mosaicism Network, ; Park, P. J.; Akbarian, S.; Lee, E. A.; Sunyaev, S. R.; Walsh, C. A.; Chess, A.

10.1101/2022.02.23.481681 — genomics — Posted on 2022-02-24

603 Extracellular RNA signatures of mutant KRAS(G12C) lung adenocarcinoma cells

Khojah, R.; Reggiardo, R.; Ozen, M.; Velandi Maroli, S.; Carrillo, D.; Demirci, U.; Kim, D. H.

10.1101/2022.02.23.481574 — genomics — Posted on 2022-02-24

604 Genome-wide Association Study Reveals that PvGUX1_1 is Associated with Pod Stringlessness in Snap Bean (Phaseolus vulgaris L.)

Liu, Z.; Gao, S.; Zhang, H.; Xu, Z.; Qian, W.

10.1101/2022.02.23.481584 — genetics — Posted on 2022-02-23

605 Systemic RNA interference-defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

Gaeta, A. L.; Nourse, J. B.; Willicott, K.; McKay, L. E.; Keogh, C. M.; Peter, K.; Russell, S. N.; Hamamichi, S.; Berkowitz, L. A.; Caldwell, K. A.; Caldwell, G. A.

10.1101/2022.02.23.481573 — genetics — Posted on 2022-02-24

606 Preferred synonymous codons are translated more accurately: Proteomic evidence, among-species variation, and mechanistic basis

Sun, M.; Zhang, J.

10.1101/2022.02.22.481448 — genetics — Posted on 2022-02-24

607 A new lineage of non-photosynthetic green algae with extreme organellar genomes

Panek, T.; Barcyte, D.; Treitli, S. C.; Zahonova, K.; Sokol, M.; Sevcikova, T.; Zadrobilkova, E.; Jaske, K.; Yubuki, N.; Cepicka, I.; Elias, M.

10.1101/2021.11.17.468966 — evolutionary biology — Posted on 2022-02-23

608 Adaptations for bipedal walking: Musculoskeletal structure and three-dimensional joint mechanics of humans and bipedal chimpanzees (Pan troglodytes)

O'Neill, M. C.; Demes, B.; Thompson, N. E.; Larson, S. G.; Stern, J. T.; Umberger, B. R.

10.1101/2022.02.21.481231 — evolutionary biology — Posted on 2022-02-23

609 Anatomy of the heart of the leatherback turtle

Jensen, B.; Lauridsen, H.; Webb, G.; Wang, T.

10.1101/2022.02.22.481434 — evolutionary biology — Posted on 2022-02-24

610 Coursing hyenas and stalking lions: the potential for inter- and intraspecific interactions

Barker, N. A.; Joubert, F. G.; Kasaona, M.; Shatumbu, G.; Stowbunenko, V.; Alexander, K. A.; Slotow, R.; Getz, W. M.

10.1101/2022.02.23.481665 — ecology — Posted on 2022-02-24

611 Maternal and/or direct supplementation with a combination of a casein hydrolysate and yeast β-glucan on post-weaning performance and intestinal health in the pig

Conway, E.; O'Doherty, J. V.; Mukhopadhya, A.; Dowley, A.; Vigors, S.; Maher, S.; Ryan, M. T.; Sweeney, T.

10.1101/2022.02.23.481664 — developmental biology — Posted on 2022-02-23

612 A light-gated transcriptional recorder for detecting cell-cell contacts

Cho, K. F.; Gillespie, S. M.; Kalogriopoulos, N. A.; Quezada, M. A.; Jacko, M.; Monje, M.; Ting, A. Y.

10.1101/2022.02.22.481562 — cell biology — Posted on 2022-02-23

613 Toxoplasma gondii-s basal complex: the other apicomplexan business end is multifunctional

Gubbels, M.-J.; Ferguson, D. J.; Saha, S.; Romano, J. D.; Chavan, S.; Primo, V. A.; Michaud, C.; Coppens, I.; Engelberg, K.

10.1101/2022.02.23.481603 — cell biology — Posted on 2022-02-24

614 Expression of Unfolded Protein Response Genes in Post-transplantation Liver Biopsies

Liu, X.; Taylor, S.; Celaj, S.; Levitsky, J.; Green, R.

10.1101/2022.02.21.480553 — molecular biology — Posted on 2022-02-23

615 Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions

Xiang, J. S.; Mueller, J. R.; Luo, E.-C.; Yee, B. A.; Schafer, D.; Schmok, J. C.; Tan, F. E.; Rothamel, K.; McVicar, R. N.; Kwong, E. M.; Jones, K. L.; Her, H.-L.; Chen, C.-Y.; Vu, A. Q.; Jin, W.; Park, S. S.; Le, P.; Brannan, K. W.; Kofman, E. R.; Li, Y.; Tankka, A. T.; Dong, K. D.; Song, Y.; Carlin, A. F.; Van Nostrand, E. L.; Leibel, S. L.; Yeo, G. W.

10.1101/2022.02.21.481223 — molecular biology — Posted on 2022-02-24

616 BET-independent MLV integration is retargeted in vivo and selects distinct genomic elements for lymphomagenesis

Nombela, I.; Michiels, M.; Van Looveren, D.; Marcelis, L.; el Ashkar, S.; Van Belle, S.; Bruggemans, A.; Tousseyn, T.; Schwaller, J.; Christ, F.; Gijsbers, R.; De Rijck, J.; Debyser, Z.

10.1101/2022.02.23.481640 — microbiology — Posted on 2022-02-23

617 Genetic diversity and connectivity of the Ostreid herpesvirus 1 populations in France: a first attempt to phylogeographic inference for a marine mollusc disease

Delmotte, J.; Pelletier, C.; Morga, B.; Galinier, R.; Petton, B.; Lamy, J.-B.; Kaltz, O.; Avarre, J.-C.; Jacquot, M.; Montagnani, C.; Escoubas, J.-M.

10.1101/2021.04.30.442107 — microbiology — Posted on 2022-02-23

618 Transertion is used for localized expression and assembly of Vibrio parahaemolyticus T3SS2

Kaval, K. G.; Chimalapati, S.; Seigel, S.; Rodriguez, N. G.; Dalia, A. B.; Orth, K.

10.1101/2022.02.23.481666 — microbiology — Posted on 2022-02-23

619 Potent Neutralizing Activity of Polyclonal Equine Antibodies against Omicron SARS-CoV-2

Luczkowiak, J.; Radreau, P.; Nguyen, L.; Labiod, N.; Lasala, F.; Herbreteau-Delale, C.; Delgado, R.

10.1101/2022.02.21.481341 — microbiology — Posted on 2022-02-23

620 Resistance of Dickeya solani strain IPO 2222 to lytic bacteriophage vB_Dsol_D5 ({Phi}D5) results in fitness tradeoffs for the bacterium during infection

Bartnik, P.; Lewtak, K.; Fiolka, M.; Czaplewska, P.; Narajczyk, M.; Czajkowski, R.

10.1101/2022.02.23.481671 — microbiology — Posted on 2022-02-23

621 Serological screening in wild ruminants in Germany, 2021/22: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus

Wernike, K.; Fischer, L.; Holsteg, M.; Aebischer, A.; Petrov, A.; Marquart, K.; Schotte, U.; Schoen, J.; Hoffmann, D.; Hechinger, S.; Neubauer-Juric, A.; Blicke, J.; Mettenleiter, T. C.; Beer, M.

10.1101/2022.02.21.481262 — microbiology — Posted on 2022-02-23

622 Tracking influenza a virus infection in the lung from hematological data with machine learning

Jhutty, S.; Boehme, J.; Jeron, A.; Volckmar, J.; Schultz, K.; Schreiber, J.; Schughart, K.; Zhou, K.; Steinheimer, J.; Stocker, H.; Stegemann-Koniszewski, S.; Bruder, D.; Hernandez Vargas, E. A.

10.1101/2022.02.23.481638 — microbiology — Posted on 2022-02-23

623 Prevalence Of Multi Drug Resistant Bacteria On Environmental And Medical Device Surfaces Of Korea Nepal Friendship Hospital

Paudel, N.; Awasthi, N. P.; Lekhak, B.; Acharya, A.

10.1101/2022.02.20.481232 — microbiology — Posted on 2022-02-23

624 Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

Torii, S.; Kim, K. S.; Koseki, J.; Suzuki, R.; Iwanami, S.; Fujita, Y.; Jeong, Y. D.; Matsuura, Y.; Shimamura, T.; Iwami, S.; Fukuhara, T.

10.1101/2022.02.22.481436 — microbiology — Posted on 2022-02-24

625 Novel and Reported Compensatory Mutations in rpoABC Associate Specifically with Predominant Mycobacterium tuberculosis Rifampicin Resistance Marker rpoB:S450L

Conkle-Gutierrez, D.; Ramirez-Busby, S. M.; Gorman, B. M.; Elghraoui, A.; Hoffner, S. E.; Elmaraachli, W.; Valafar, F.

10.1101/2022.02.22.481565 — microbiology — Posted on 2022-02-24

626 A single-dose of the deactivated rabies virus vectored COVID-19 vaccine, CORAVAX, is highly efficacious and alleviates lung inflammation in the hamster model.

Schnell, M. J.

10.1101/2022.02.21.481324 — microbiology — Posted on 2022-02-24

627 Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission

Virtanen, J.; Aaltonen, K.; Kegler, K.; Venkat, V.; Niamsap, T.; Kareinen, L.; Malmgren, R.; Kivela, O.; Atanasova, N.; Osterlund, P.; Smura, T.; Sukura, A.; Strandin, T.; Dutra, L.; Vapalahti, O.; Nordgren, H.; Kant, R.; Sironen, T.

10.1101/2022.02.16.480524 — microbiology — Posted on 2022-02-24

628 Mucosal Immunization of Cynomolgus Macaques with Adenoviral Vector Vaccine Elicits Neutralizing Nasal and Serum Antibody to Several SARS-CoV-2 Variants

Flitter, B. A.; Lester, C. A.; Tedjakusuma, S. N.; Dora, E. G.; Peinovich, N.; Cortese, M.; Martinez, C. I.; Jegede, C. B.; Neuhaus, E. D.; Tucker, S. N.

10.1101/2022.02.21.481345 — immunology — Posted on 2022-02-23

629 Omicron booster in ancestral strain vaccinated mice augments protective immunities against both the Delta and Omicron variants

Jia, L.; Zhou, Y.; Li, S.; Zhang, Y.; Yan, D.; Wang, W.; Zhang, W.; Wan, Y. m.; Qiu, C.

10.1101/2022.02.19.481110 — immunology — Posted on 2022-02-23

630 Towards a unified model of naive T cell dynamics across the lifespan

Rane, S.; Hogan, T.; Lee, E.; Seddon, B.; Yates, A.

10.1101/2022.01.07.475400 — immunology — Posted on 2022-02-23

631 SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses

Tandel, D.; Sah, V.; Singh, N. K.; Potharaju, P. S.; Gupta, D.; Shrivastava, S.; Sowpati, D. T.; Harshan, K. H.

10.1101/2022.02.22.481430 — immunology — Posted on 2022-02-23

632 RNA-based vaccine demonstrates prophylactic efficacy against Mycobacterium tuberculosis challenge in a mouse model

Larsen, S. E.; Erasmus, J. H.; Reese, V. A.; Pecor, T.; Archer, J.; Khandhar, A. P.; Hsu, F.-C.; Reed, S. G.; Baldwin, S. L.; Coler, R. N.

10.1101/2022.02.23.481669 — immunology — Posted on 2022-02-24

633 Sensory-motor computations in a cortico-pontine pathway

Darlington, T. R.; Lisberger, S. G.

10.1101/2022.02.22.481514 — neuroscience — Posted on 2022-02-23

634 Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

Lukasz, D.; Beirl, A.; Kindt, K.

10.1101/2022.02.22.481465 — neuroscience — Posted on 2022-02-23

635 A Neuropsin-based Optogenetic Tool for Precise Control of Gq signaling

Luo, M.; Dai, R.; Yu, T.; Weng, D.; Li, H.; Cui, Y.; Wu, Z.; Guo, Q.; Zou, H.; Wu, W.; Gao, X.; Qi, Z.; Ren, Y.; Shu, W.; Li, Y.

10.1101/2022.02.22.481462 — neuroscience — Posted on 2022-02-23

636 Efficacy and sex differences in the effects on rat brain microglia of the colony-stimulating factor 1 receptor inhibitor-PLX5622

Sharon, A.; Erez, H.; Spira, M. E.

10.1101/2022.02.22.481449 — neuroscience — Posted on 2022-02-23

637 A Cryptochrome adopts distinct moon- and sunlight states and functions as moonlight interpreter in monthly oscillator entrainment

Poehn, B.; Krishnan, S.; Zurl, M.; Coric, A.; Rokvic, D.; Haefker, N. S.; Arboleda, E.; Orel, L.; Raible, F.; Wolf, E.; Tessmar-Raible, K.

10.1101/2021.04.16.439809 — neuroscience — Posted on 2022-02-23

638 Age-induced changes in Mu Opioid Receptor signaling in the midbrain Periaqueductal Gray of male and female rats

Fullerton, E. F.; Karom, M. C.; Streicher, J. M.; Young, L.; Murphy, A. Z.

10.1101/2022.01.13.475945 — neuroscience — Posted on 2022-02-23

639 Movement planning and feedback are sufficient for sensory prediction error computation and motor adaptation

Kim, O. A.; Forrence, A. D.; McDougle, S. D.

10.1101/2021.08.12.456140 — neuroscience — Posted on 2022-02-23

640 Real-time image processing toolbox for all-optical closed-loop control of neuronal activities

Sheng, W.; Zhao, X.; Huang, X.; Yang, Y.

10.1101/2020.06.22.166140 — neuroscience — Posted on 2022-02-23

641 Patterns of connectome variability in autism across five functional activation tasks. Fndings from the LEAP project

Looden, T.; Floris, D. L.; Llera Arenas, A.; Chauvin, R. J.; Charman, T.; Banaschewski, T.; Murphy, D.; Marquand, A. F.; Buitelaar, J. K.; Beckmann, C. F.; the AIMS-2-TRIALS group,

10.1101/2022.02.22.481408 — neuroscience — Posted on 2022-02-23

642 A model of colour appearance based on efficient coding of natural images

Troscianko, J.; Osorio, D.

10.1101/2022.02.22.481414 — neuroscience — Posted on 2022-02-23

643 Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

Fennell, E. M. J.; Aponte-Collazo, L. J.; Wynn, J. D.; Drizyte-Miller, K.; Leung, E.; Greer, Y. E.; Graves, P. R.; Iwanowicz, A. A.; Ashamalla, H.; Holmuhamedov, E.; Lang, H.; Karanewsky, D. S.; Der, C. J.; Houry, W. A.; Lipkowitz, S.; Iwanowicz, E. J.; Graves, L. M.

10.1101/2022.02.14.480426 — pharmacology and toxicology — Posted on 2022-02-23

644 Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer

Datta, J.; Dai, X.; Bianchi, A.; De Castro Silva, I.; Mehra, S.; Garrido, V. T.; Lamichhane, P.; Singh, S.; Zhou, Z.; Dosch, A. R.; Messagio, F.; Ban, Y.; Umland, O.; Hosein, P. J.; Nagathihalli, N.; Merchant, N.

10.1101/2021.03.07.434236 — cancer biology — Posted on 2022-02-23

645 Genomic hallmarks and therapeutic implications of cancer cell quiescence

Wiecek, A. J.; Cutty, S. J.; Kornai, D.; Parreno-Centeno, M.; Gourmet, L. E.; Malagoli Tagliazucchi, G.; Jacobson, D. H.; Zhang, P.; Xiong, L.; Bond, G. L.; Barr, A. R.; Secrier, M.

10.1101/2021.11.12.468410 — cancer biology — Posted on 2022-02-23

646 Inter-subunit coupling enables fast CO2-fixation by reductive carboxylases

Demirci, H.; Rao, Y.; Stoffel, G. M.; Vögeli, B.; Schell, K.; Gomez, A.; Batyuk, A.; Gati, C.; Sierra, R. G.; Hunter, M. S.; Dao, E. H.; Ciftci, H. I.; Hayes, B.; Poitevin, F.; Li, P.; Kaur, M.; Tono, K.; Adrian Saez, D.; Deutsch, S.; Yoshikuni, Y.; Grubmueller, H.; Erb, T. J.; Vöhringer-Martinez, E.; Wakatsuki, S.

10.1101/607101 — biophysics — Posted on 2022-02-23

647 Predicting the Functional Impact of KCNQ1 Variants with Artificial Neural Networks

Phul, S.; Kuenze, G.; Vanoye, C. G.; Sanders, C. R.; George, A. L.; Meiler, J.

10.1101/2021.12.06.471347 — biophysics — Posted on 2022-02-23

648 Multiscale Modeling of Hepatitis B Virus Capsid Assembly and its Dimorphism

Mohajerani, F.; Tyukodi, B.; Schlicksup, C. J.; Hadden-Perilla, J. A.; Zlotnick, A.; Hagan, M. F.

10.1101/2022.02.23.481637 — biophysics — Posted on 2022-02-23

649 MetaboListem and TABoLiSTM: Two Deep Learning Algorithms for Metabolite Named Entity Recognition

Yeung, C. S.; Beck, T.; Posma, J. M.

10.1101/2022.02.22.481457 — bioinformatics — Posted on 2022-02-23

650 An in-silico study of the mutation-associated effects on the spike protein of SARS-CoV-2, Omicron variant

Shishir, T. A.; Jannat, T.; Naser, I. B.

10.1101/2022.02.21.481269 — bioinformatics — Posted on 2022-02-23

651 scDVF: Data-driven Single-cell Transcriptomic Deep Velocity Field Learning with Neural Ordinary Differential Equations

Chen, Z.; King, W. C.; Gerstein, M.; Zhang, J.

10.1101/2022.02.15.480564 — bioinformatics — Posted on 2022-02-23

652 Combining SLA 3D printing and soft lithography for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

Hagemann, C.; Bailey, M. C. D.; Khokhar, N.; Lionello, V. M.; Suklai, P.; Moreno-Gonzalez, C.; O'Toole, K.; Konstantinou, G.; Giagnorio, E.; Bergholt, M.; Imbert, A.; Tedesco, F. S.; Serio, A.

10.1101/2022.02.22.481424 — bioengineering — Posted on 2022-02-23

653 Biochemical characterization of RAD52-mediated D-loop formation using fluorophore-labeled DNA substrates

Kamoi, K.; Saotome, M.; Kinoshita, C.; Tsuchiya, R.; Kagawa, W.

10.1101/2022.02.23.481227 — biochemistry — Posted on 2022-02-23

654 Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA

Wurm, J. P.

10.1101/2022.02.23.481582 — biochemistry — Posted on 2022-02-23

655 Human Group Size Puzzle: Why It Is Odd That We Live in Large Societies

David-Barrett, T.

10.1101/2022.02.18.481060 — animal behavior and cognition — Posted on 2022-02-23

656 Large haplotypes highlight a complex age structure within the maize pan-genome

Liu, J.; Dawe, R. K.

10.1101/2022.02.22.481510 — genomics — Posted on 2022-02-23

657 Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores

Prive, F.; Arbel, J.; Aschard, H.; Vilhjalmsson, B. J.

10.1101/2021.03.29.437510 — genetics — Posted on 2022-02-23

658 Functional involvement of multiple genes as members of the supergene unit in the female-limited Batesian mimicry of Papilio polytes

Komata, S.; Yoda, S.; KonDo, Y.; Shinozaki, S.; Tamai, K.; Fujiwara, H.

10.1101/2022.02.21.480812 — genetics — Posted on 2022-02-23

659 Intergenerational transfer and sex differences of DNA methylation patterns in the Pacific oyster (Crassostrea gigas)

Li, Y.; Teng, W.; Xu, C.; Yu, H.; Kong, L.; Liu, S.; Li, Q.

10.1101/2022.02.22.481396 — evolutionary biology — Posted on 2022-02-23

660 Ancient Darwinian replicators nested within eubacterial genomes

Bertels, F.; Rainey, P. B.

10.1101/2021.07.10.451892 — evolutionary biology — Posted on 2022-02-23

661 Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns

Shahal, T.; Segev, E.; Konstantinovsky, T.; Marcus, Y.; Shefer, G.; Pasmanik-Chor, M.; Buch, A.; Ebenstein, Y.; Zimmet, P.; Stern, N.

10.1101/2021.06.20.449142 — developmental biology — Posted on 2022-02-23

662 Live-Cell Imaging in Human Colonic Monolayers Reveals Erk Waves Limit the Stem Cell Compartment to Maintain Epithelial Homeostasis

Pond, K. W.; Alkhimenok, O.; Chakrabarti, J.; Zavros, Y.; Thorne, C. A.; Paek, A. L.

10.1101/2022.02.23.481374 — cell biology — Posted on 2022-02-23

663 The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility

Kaur, R.; Leigh, B. A.; Ritchie, I. T.; Bordenstein, S. R.

10.1101/2022.01.15.476471 — cell biology — Posted on 2022-02-23

664 PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

Perea, V.; Cole, C.; Lebeau, J.; Dolina, V.; Baron, K. R.; Madhavan, A.; Kelly, J. W.; Grotjahn, D.; Wiseman, R. L.

10.1101/2022.02.23.481593 — cell biology — Posted on 2022-02-23

665 Chronic Glucocorticoid Stress Reveals Increased Energy Expenditure and Accelerated Aging as Cellular Features of Allostatic Load

Bobba-Alves, N.; Sturm, G.; Lin, J.; Ware, S. A.; Karan, K. R.; Monzel, A. S.; Bris, C.; Procaccio, V.; Lenaers, G.; Higgins-Chen, A.; Levine, M.; Horvath, S.; Santhanam, B. S.; Kaufman, B. A.; Hirano, M.; Epel, E. S.; Picard, M.

10.1101/2022.02.22.481548 — cell biology — Posted on 2022-02-23

666 Wide-field Calcium Imaging Reveals Widespread Changes in Cortical Connectivity Following Repetitive, Mild Traumatic Brain Injury in the Mouse

Cramer, S. W.; Haley, S. P.; Popa, L. S.; Carter, R. E.; Scott, E. P.; Flaherty, E. B.; Dominguez, J.; Aronson, J. D.; Sabal, L.; Surinach, D.; Chen, C. C.; Kodandaramaiah, S. B.; Ebner, T. J.

10.1101/2022.02.22.481459 — neuroscience — Posted on 2022-02-23

667 NOMIS: Quantifying morphometric deviations from normality over the lifetime of the adult human brain

Potvin, O.; Dieumegarde, L.; Duchesne, S.; Alzheimer's Disease Neuroimaging Initiative and CIMA-Q,

10.1101/2021.01.25.428063 — neuroscience — Posted on 2022-02-23

668 Neural Kernels for Recursive Support Vector Regression as a Model for Episodic Memory

Leibold, C.

10.1101/2022.02.22.481458 — neuroscience — Posted on 2022-02-23

669 Built on sand: the shaky foundations of simulating single-cell RNA sequencing data

Crowell, H. L.; Leonardo, S. X. M.; Soneson, C.; Robinson, M. D.

10.1101/2021.11.15.468676 — bioinformatics — Posted on 2022-02-23

670 A highly sensitive LC-MS/MS method for quantitative determination of 7 vitamin D metabolites in mouse brain tissue

Stephenson, A.; Hunter, B.; Shaw, P. N.; Kassim, N. S. A.; Trengrove, R.; Takechi, R.; Lam, V.; Mamo, J.

10.1101/2022.02.21.481384 — physiology — Posted on 2022-02-23

671 Cell cycle progression requires repression by Groucho during S-phase and its relief at G2-phase

PAROUSH, Z.; Bar-Cohen, S.

10.1101/2022.02.22.481413 — developmental biology — Posted on 2022-02-23

672 A glimpse into the DNA virome of the unique "living fossil" Welwitschia mirabilis

Debat, H.; Bejerman, N.

10.1101/2022.02.23.481439 — microbiology — Posted on 2022-02-23

673 Distribution of the National Science Foundation's Advancing Informal STEM Learning Awards (AISL) between 2006-21

Houzenga, H. M.; Muindi, F. J.

10.1101/2022.02.18.480415 — scientific communication and education — Posted on 2022-02-23

674 High-resolution lung adenocarcinoma expression subtypes identify tumors with dependencies on MET, CDK4, CDK6, and PD-L1

Roh, W.; Geffen, Y.; Miller, M.; Anand, S.; Kim, J.; Heiman, D.; Gainor, J. F.; Laird, P. W.; Cherniack, A. D.; National Cancer Institute Center for Cancer Genomics Tumor Molecular Pathology (TMP) AWG, ; Getz, G.

10.1101/2022.02.20.481157 — cancer biology — Posted on 2022-02-23

675 An Ethogram Identifies Behavioural Markers of Attention to Humans in European Herring Gulls (Larus argentatus)

Feist, F.; Graham, P.

10.1101/2022.02.20.481240 — animal behavior and cognition — Posted on 2022-02-23

676 Practical application of indicators for genetic diversity in CBD post-2020 Global Biodiversity Framework implementation

Thurfjell, H.; Laikre, L.; Ekblom, R.; Hoban, S.; Sjogren-Gulve, P.

10.1101/2022.02.18.481087 — genetics — Posted on 2022-02-23

677 Honey bees change the microbiota of pollen

Prado, A.; Barret, M.; Vaissiere, B. E.; Torres-Cortes, G.

10.1101/2022.02.21.481367 — ecology — Posted on 2022-02-23

678 Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

Obradovic, A.; Ager, C.; Turunen, M.; Nirschl, T.; Khosravi-Maharlooei, M.; Jackson, C.; Yegnasubramanian, V.; DeMarzo, A.; Kochel, C.; Allaf, M.; Bivalacqua, T.; Lim, M.; Karan, C.; Drake, C.; Califano, A.

10.1101/2022.02.22.481404 — cancer biology — Posted on 2022-02-23

679 Onset and kinetics of B cell polarization depend on substrate mechanics and antigen concentration

Pinon, L.; Ruyssen, N.; Pineau, J.; Mesdjian, O.; Cuvelier, D.; Allena, R.; Asnacios, S.; Asnacios, A.; Pierobon, P.; Fattaccioli, J.

10.1101/2021.12.22.473360 — biophysics — Posted on 2022-02-23

680 MIAMI: Mutual Information-based Analysis of Multiplex Imaging data

Seal, S.; Ghosh, D.

10.1101/2022.02.10.479967 — bioinformatics — Posted on 2022-02-23

681 Quantifying the effect of caloric and non-caloric sweeteners in the brain response using EEG and convolutional neural network

Atzingen, G. V. v.; Minano, H. L. A.; Silva, A. R.; Ortega, N. F.; Costa, E. J. X.; Silva, A. C. d. S.

10.1101/2021.10.25.465723 — bioengineering — Posted on 2022-02-23

682 Breeding site microbiota and oviposition: do female Aedes aegypti shape bacterial communities?

Mosquera Duran, K. D.; MartinezVillegas, L. E.; da Rocha Fernandes, G.; Rocha David, M.; Maciel de Freitas, R.; Moreira, L. A.; Lorenzo, M. G.

10.1101/2022.02.22.481482 — ecology — Posted on 2022-02-23

683 Mechano-signaling feedback underlies precise inner hair cell patterning in the organ of Corti

Cohen, R.; Taiber, S.; Loza, O.; Kasirer, S.; Woland, S.; Sprinzak, D.

10.1101/2022.01.24.477468 — developmental biology — Posted on 2022-02-23

684 Associative memory of structured knowledge

Steinberg, J.; Sompolinsky, H.

10.1101/2022.02.22.481380 — neuroscience — Posted on 2022-02-23

685 Influence of claustrum on cortex varies by area, layer, and cell type

McBride, E. G.; Gandhi, S. R.; Kuyat, J. R.; Ollerenshaw, D. R.; Arkhipov, A.; Koch, C.; Olsen, S. R.

10.1101/2022.02.22.481532 — neuroscience — Posted on 2022-02-23

686 Long-term learning transforms prefrontal cortex selectivity during working memory

Miller, J.; Tambini, A.; Kiyonaga, A.; D'Esposito, M.

10.1101/2022.02.22.481537 — neuroscience — Posted on 2022-02-23

687 Dynamic Sex Differences in Reactive and Appetitive Aggression

Aubry, A.; Burnett, C. J.; Goodwin, N.; Li, L.; Navarrete, J.; Zhang, Y.; Tsai, V.; Durand-de Cuttoli, R.; Golden, S.; Russo, S.

10.1101/2022.02.22.481480 — neuroscience — Posted on 2022-02-23

688 Lifelong learning of cognitive strategies for physical problem-solving: the effect of embodied experience

Allen, K. R.; Smith, K.; Bird, L.-A.; Tenenbaum, J. B.; Makin, T.; Cowie, D.

10.1101/2021.07.08.451333 — neuroscience — Posted on 2022-02-23

689 Visualizing cancer-originated acetate uptake through MCT1 in reactive astrocytes demarcates tumor border and extends survival in glioblastoma patients

Ko, H. Y.; Chung, J.-I.; Kim, D.; Park, Y. M.; Jo, H. H.; Lee, S.; Kim, S. Y.; Kim, J.; Chun, J.-H.; Han, K.-S.; Lee, M.; Ju, Y.; Park, S. J.; Park, K. D.; Nam, M.-H.; Park, Y.; Kim, S. H.; Shim, J.-K.; Kang, S.-G.; Chang, J. H.; Lee, C. J.; Yun, M.

10.1101/2021.04.13.439750 — cancer biology — Posted on 2022-02-22

690 Predicting direct physical interactions in multimeric proteins with deep learning

Gao, M.; An, D. N.; Parks, J. M.; Skolnick, J.

10.1101/2021.11.09.467949 — bioinformatics — Posted on 2022-02-22

691 Sonic Hedgehog is not a limb morphogen but acts as a trigger to specify all digits.

Zhu, J.; Patel, R.; Trofka, A.; Harfe, B. D.; Mackem, S.

10.1101/2020.05.28.122119 — developmental biology — Posted on 2022-02-22

692 Urocortin-3 neurons in the perifornical area mediate the impact of chronic stress on female infant-directed behavior

Abdelmesih, B.; Carta, I.; Anderson, R.; Autry, A. E.

10.1101/2022.02.19.481074 — neuroscience — Posted on 2022-02-22

693 Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology

Banks, M. I.; Krause, B. M.; Berger, D. G.; Campbell, D. I.; Boes, A. D.; Bruss, J. E.; Kovach, C. K.; Kawasaki, H.; Steinschneider, M.; Nourski, K. V.

10.1101/2022.02.06.479292 — neuroscience — Posted on 2022-02-22

694 Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics

Huwiler, S.; Dominguez, M. C.; Huwyler, S.; Kiener, L.; Stich, F.; Sala, R.; Aziri, F.; Trippel, A.; Schmied, C.; Huber, R.; Wenderoth, N.; Lustenberger, C.

10.1101/2022.02.16.480303 — neuroscience — Posted on 2022-02-22

695 Generative neural networks separate common and specific transcriptional responses

Lee, A. J.; Mould, D. L.; Crawford, J.; Hu, D.; Powers, R. K.; Doing, G.; Costello, J. C.; Hogan, D. A.; Greene, C. S.

10.1101/2021.05.24.445440 — bioinformatics — Posted on 2022-02-22

696 Foldseek: fast and accurate protein structure search

van Kempen, M.; Kim, S.; Tumescheit, C.; Mirdita, M.; Soeding, J.; Steinegger, M.

10.1101/2022.02.07.479398 — bioinformatics — Posted on 2022-02-22

697 Cell type-specific inference of differential expression in spatial transcriptomics

Cable, D. M.; Murray, E.; Shanmugam, V.; Zhang, S.; Diao, M. Z.; Chen, H.; Macosko, E.; Irizarry, R. A.; Chen, F.

10.1101/2021.12.26.474183 — genomics — Posted on 2022-02-22

698 hibayes: An R Package to Fit Individual-Level, Summary-Level and Single-Step Bayesian Regression Models for Genomic Prediction and Genome-Wide Association Studies

Yin, L.; Zhang, H.; Li, X.; Zhao, S.; Liu, X.

10.1101/2022.02.12.480230 — genetics — Posted on 2022-02-22

699 Population structure and genetic connectivity of the scalloped hammerhead shark (Sphyrna lewini) across nursery grounds from the Eastern Tropical Pacific: implications for management and conservation

Elizondo-Sancho, M.; Rodriguez-Arriatti, Y. N.; Albertazzi, F. J.; Bonilla-Salazar, A.; Arauz-Naranjo, D.; Arauz, R.; Areano, E.; Avalos-Castillo, C.; Brenes, O.; Chavez, E. J.; Dominici-Arosemena, A.; Espinoza, M.; Heidemeyer, M.; Tavares, R.; Hernandez, S.

10.1101/2022.02.22.481487 — genetics — Posted on 2022-02-22

700 Context-dependence in the symbiosis between Dictyostelium discoideum and Paraburkholderia

Scott, T. J.; Queller, D. C.; Strassmann, J. E.

10.1101/2021.09.17.459779 — evolutionary biology — Posted on 2022-02-22

701 Diversification of small RNA pathways underlies germline RNAi incompetence in wild C. elegans strains

Chou, H. T.; Valencia, F.; Alexander, J. C.; Bell, A. D.; Deb, D.; Pollard, D. A.; Paaby, A. B.

10.1101/2021.08.21.457212 — evolutionary biology — Posted on 2022-02-22

702 Rapid multilocus adaptation of clonal cabbage leaf curl virus populations to Arabidopsis thaliana

Hoyer, J. S.; Wilkins, O. W.; Munshi, A.; Wiese, E.; Dubey, D.; Renard, S.; Mortensen, K. R. H.; Dye, A. E.; Carbone, I.; Duffy, S.; Ascencio-Ibanez, J. T.

10.1101/2021.11.29.468282 — evolutionary biology — Posted on 2022-02-22

703 Caveat in Fisher's theorem reveals fitness can change without mutations

Reding, C.

10.1101/810259 — evolutionary biology — Posted on 2022-02-22

704 Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2

Cui, H.; Diedrich, J. K.; Wu, D. C.; Lim, J. J.; Nottingham, R. M.; Moresco, J. J.; Yates, J. R.; Blencowe, B.; Lambowitz, A. M.; Schimmel, P.

10.1101/2021.09.07.459304 — molecular biology — Posted on 2022-02-22

705 Fibromodulin Ablation Exacerbates the Severity of Acute DSS Colitis

Halasi, M.; Grinstein, M.; Adini, A.; Adini, I.

10.1101/2022.01.12.475640 — immunology — Posted on 2022-02-22

Bloom, P. A.; VanTieghem, M.; Gabard-Durnam, L.; Gee, D. G.; Flannery, J.; Caldera, C.; Goff, B.; Telzer, E. H.; Humphreys, K. L.; Fareri, D. S.; Shapiro, M.; Algharazi, S.; Bolger, N.; Aly, M.; Tottenham, N.

10.1101/2021.10.08.463601 — neuroscience — Posted on 2022-02-22

707 Parent-Child Autonomic Synchrony During Vicarious Extinction Learning in Pediatric PTSD

George, G. C.; Heyn, S. A.; Konishi, S.; Marin, M.-F.; Herringa, R. J.

10.1101/2022.01.12.476063 — neuroscience — Posted on 2022-02-22

708 A wearable platform for closed-loop stimulation and recording of single- neuron and local field potential activity in freely-moving humans

Topalovic, U.; Barclay, S.; Ling, C.; Alzuhair, A.; Yu, W.; Hokhikyan, V.; Chandrakumar, H.; Rozgic, D.; Jiang, W.; Basir-Kazeruni, S.; Maoz, S. L.; Inman, C. S.; Gill, J.; Bari, A.; Fallah, A.; Eliashiv, D.; Pouratian, N.; Fried, I.; Suthana, N.; Markovic, D.

10.1101/2022.02.05.479253 — neuroscience — Posted on 2022-02-22

709 Emergent selectivity for scenes, object properties, and contour statistics in feedforward models of scene-preferring cortex

Li, S. P. D.; Bonner, M. F.

10.1101/2021.09.24.461733 — neuroscience — Posted on 2022-02-22

710 Symptomatic and Disease-Modifying Effects of GABAA Receptor Positive Allosteric Modulation in a Mouse Model of Chronic Stress

Bernardo, A.; Lee, P.; Marcotte, M.; Mian, Y.; Rezvanian, S.; Sharmin, D.; Cook, J. M.; Sibille, E.; Prevot, T. D.

10.1101/2021.03.22.436517 — neuroscience — Posted on 2022-02-22

711 A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis

Dorman, L. C.; Nguyen, P. T.; Escoubas, C. C.; Vainchtein, I. D.; Xiao, Y.; Lidsky, P. V.; Nakajo, H.; Silva, N. J.; Lagares-Linares, C.; Wang, E. Y.; Taloma, S. E.; Cuevas, B.; Nakao-Inoue, H.; Rivera, B. M.; Schwer, B. J.; Condello, C.; Andino, R.; Nowakowski, T. J.; Molofsky, A. V.

10.1101/2021.04.29.441889 — neuroscience — Posted on 2022-02-22

712 Fides: Reliable Trust-Region Optimization for Parameter Estimation of Ordinary Differential Equation Models

Froehlich, F.; Sorger, P. K.

10.1101/2021.05.20.445065 — systems biology — Posted on 2022-02-22

713 Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli

Williams, R. L.; Murray, R. M.

10.1101/614529 — synthetic biology — Posted on 2022-02-22

714 Common coupling map advances GPCR-G protein selectivity

Hauser, A. S.; Avet, C.; Normand, C.; Manchini, A.; Inoue, A.; Bouvier, M.; Gloriam, D.

10.1101/2021.09.07.459250 — pharmacology and toxicology — Posted on 2022-02-22

715 Mechanical loading of cranial joints minimizes the craniofacial phenotype in Crouzon syndrome

Moazen, M.; Hejazi, M.; Savery, D.; Jones, D.; Marghoub, A.; Alazmani, A.; Pauws, E.

10.1101/2021.08.31.458360 — biophysics — Posted on 2022-02-22

716 The RNA binding protein Nab2 genetically interacts with multiple RNA exosome cofactors to regulate target RNAs

Kinney, C. E.; Mills-Lujan, K.; Fasken, M. B.; Corbett, A. H.

10.1101/2022.02.22.481433 — genetics — Posted on 2022-02-22

717 A microfluidic platform for characterizing the structure and rheology of biofilm streamers

Savorana, G.; Slomka, J.; Stocker, R.; Rusconi, R.; Secchi, E.

10.1101/2022.02.22.481486 — biophysics — Posted on 2022-02-22

718 Tie-lines reveal interactions driving heteromolecular condensate formation

Qian, D.; Welsh, T. J.; Erkamp, N. A.; Qamar, S. S.; Nixon-Abell, J.; St George-Hyslop, P.; Michaels, T.; Knowles, T.

10.1101/2022.02.22.481401 — biophysics — Posted on 2022-02-22

719 High-dimension to high-dimension screening for detecting genome-wide epigenetic regulators of gene expression

Ke, H.; Ren, Z.; Chen, S.; Tseng, G. C.; Qi, J.; Ma, T.

10.1101/2022.02.21.481160 — bioinformatics — Posted on 2022-02-22

720 MolEvolvR: a web-app for characterizing proteins using molecular evolution and phylogeny

Burke, J. T.; Chen, S. Z.; Sosinski, L. M.; Johnston, J. B.; Ravi, J.

10.1101/2022.02.18.461833 — genomics — Posted on 2022-02-22

721 Systematic analysis of ADP-ribose detection reagents and optimisation of sample preparation to detect ADP-ribosylation in vitro and in cells

Weixler, L.; Voorneveld, J.; Aydin, G.; Bolte, T. M. H. R.; Momoh, J.; Buetepage, M.; Golzmann, A.; Luescher, B.; Filippov, D. V.; Zaja, R.; Feijs, K. L.

10.1101/2022.02.22.481411 — molecular biology — Posted on 2022-02-22

722 Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control

Baker, M.; Williams, A. D.; Hooton, S. P. T.; Helliwell, R.; King, E.; Dodsworth, T.; Baena-Nogueras, R. M.; Warry, A.; Ortori, C. A.; Todman, H.; Gray-Hammerton, C. J.; Pritchard, A. C. W.; Iles, E.; Cook, R.; Emes, R. D.; Jones, M. A.; Kypraios, T.; West, H.; Barrett, D. A.; Ramsden, S. J.; Gomes, R. L.; Hudson, C.; Millard, A. D.; Raman, S.; Morris, C.; Dodd, C. E. R.; Kreft, J.-U.; Hobman, J. L.; Stekel, D. J.

10.1101/2022.02.22.481441 — microbiology — Posted on 2022-02-22

723 Modeling the tonotopic map using a two-dimensional array of neural oscillators

Biswas, D.; Chakravarthy, V. S.; Tarsode, A.

10.1101/2022.02.21.481388 — neuroscience — Posted on 2022-02-22

724 Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

Stratton, M.; Lopez-Dominguez, J. A.; Canella, A.; Ramsey, J. J.; Cortopassi, G. A.

10.1101/2022.02.22.481437 — physiology — Posted on 2022-02-22

725 Social dominance and reproduction result in increased integration of oxidative state in males of an African cichlid fish

Fialkowski, R. J.; Border, S. E.; Bolitho, I.; Dijkstra, P. D.

10.1101/2022.02.22.481488 — physiology — Posted on 2022-02-22

726 Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma

Elangovan, A.; Hooda, J.; Savariau, L.; Puthanmadhomnarayanan, S.; Yates, M. E.; Chen, J.; Brown, D. D.; McAuliffe, P. F.; Oesterreich, S.; Atkinson, J. M.; Lee, A. V.

10.1101/2022.02.22.480917 — cancer biology — Posted on 2022-02-22

727 SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

Sluimer, L. M.; Bullock, E.; Ratze, M.; Enserink, L.; Hornsveld, M.; Brunton, V. G.; Derksen, P. W. B.; Tavares, S.

10.1101/2022.02.22.481420 — cancer biology — Posted on 2022-02-22

728 Structural Basis of HIV-1 Maturation Inhibitor Binding and Activity

Sarkar, S.; Zadrozny, K. K.; Zadorozhnyi, R.; Russell, R. W.; Quinn, C. M.; Kleinpeter, A.; Ablan, S.; Xu, C.; Perilla, J. R.; Freed, E. O.; Ganser-Pornillos, B. K.; Pornillos, O.; Gronenborn, A. M.; Polenova, T.

10.1101/2022.02.22.481470 — biophysics — Posted on 2022-02-22

729 LazyPair: scalable prediction of protein-protein interactions and interaction types

Lim, C. S.; Bhandari, B. K.; Gardner, P. P.

10.1101/2022.02.21.481370 — bioinformatics — Posted on 2022-02-22

730 Truvari: Refined Structural Variant Comparison Preserves Allelic Diversity

ENGLISH, A. C.; Menon, V. K.; Gibbs, R. A.; Metcalf, G. A.; Sedlazeck, F. J.

10.1101/2022.02.21.481353 — bioinformatics — Posted on 2022-02-22

731 Structure-based design and characterization of Parkin activating mutations

Trempe, J.-F.; Stevens, M. U.; Croteau, N.; Eldeeb, M. A.; Zeng, Z. W.; Toth, R.; Durcan, T. M.; Springer, W.; Fon, E. A.; Muqit, M. M. K.

10.1101/2022.02.22.481412 — biochemistry — Posted on 2022-02-22

732 Introducing an argonaute-facilitated PCR platform

Gao, F.; Han, C.; Han, B.; Chen, Y.; Yang, J.; Sun, F.

10.1101/2022.02.22.481407 — biochemistry — Posted on 2022-02-22

733 piRNA-like small RNAs target transposable elements in a Clade IV parasitic nematode

Suleiman, M.; Kohnosu, A.; Murcott, B.; Dayi, M.; Pawluk, R.; Yoshida, A.; Viney, M.; Kikuchi, T.; Hunt, V. L.

10.1101/2022.02.21.481297 — genomics — Posted on 2022-02-22

734 Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster

Ortega, A.; Cruz, S.; Vazquez, M.; Zurita, M.

10.1101/2022.02.21.481378 — genetics — Posted on 2022-02-22

735 Characterization of Arabian Peninsula whole exomes: exploring high inbreeding features

Ferreira, J. C.; Alshamali, F.; Pereira, L.; Fernandes, V.

10.1101/2022.02.22.481461 — genetics — Posted on 2022-02-22

736 Evolutionary changes in the chromatin landscape reshape a developmental gene regulatory network during rapid life history divergence in sea urchins

Davidson, P. L.; Byrne, M.; Wray, G. A.

10.1101/2022.02.22.481523 — evolutionary biology — Posted on 2022-02-22

737 Breeding site microbiota and oviposition: do female Aedes aegypti shape bacterial communities?

Mosquera Duran, K. D.; MartinezVillegas, L. E.; da Rocha Fernandes, G.; Rocha David, M.; Maciel de Freitas, R.; Moreira, L. A.; Lorenzo, M. G.

10.1101/2022.02.22.481482 — ecology — Posted on 2022-02-22

738 Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischaemic injury

Shakked, A.; Petrover, Z.; Aharonov, A.; Ghiringhelli, M.; Umansky, K.-B.; Nguyen, P. D.; Kain, D.; Elkahal, J.; Divinsky, Y.; Miyara, S.; Friedlander, G.; Savidor, A.; Zhang, L.; Perez, D.; Kastan, N.; Lendengolts, D.; Levin, Y.; Bakkers, J.; Gepstein, L.; Tzahor, E.

10.1101/2022.02.22.481415 — cell biology — Posted on 2022-02-22

739 The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Chandra, V.; Ibrahim, H.; Halliez, C.; Prasad, R. B.; Vecchio, F.; Dwivedi, O. P.; Kvist, J.; Balboa, D.; Saarimäki-Vire, J.; Montaser, H.; Barsby, T.; Lithovius, V.; Artner, I.; Gopalakrishnan, S.; Groop, L.; Mallone, R.; Eizirik, D. L.; Otonkoski, T.

10.1101/2022.02.22.481272 — molecular biology — Posted on 2022-02-22

740 Stress granules promote chemoresistance by triggering cellular quiescence

Khong, A.; Ripin, N.; Macedo de Vasconcelos, L.; Spencer, S. L.; Parker, R.

10.1101/2022.02.22.481503 — molecular biology — Posted on 2022-02-22

741 Identification of a CCG-enriched expanded allele in DM1 patients using Amplification-free long-read sequencing

Tsai, Y.-C.; de Pontual, L.; Heiner, C.; Stojkovic, T.; Furling, D.; Bassez, G.; Genevieve, G.; Tome, S.

10.1101/2022.02.22.481438 — molecular biology — Posted on 2022-02-22

742 Lysine acetylation regulates antibiotic resistance in Escherichia coli

Fang, Z.; Lai, F.; Cao, K.; Zhang, Z.; Cao, L.; Liu, S.; Duan, Y.; Yin, X.; Ge, R.; He, Q.-Y.; Sun, X.

10.1101/2022.02.22.481468 — microbiology — Posted on 2022-02-22

743 Inactivation of B. cereus Spores in Whole Milk and Almond Milk by Novel Serpentine Path Coiled Tube UV-C System

Pendyala, B.; Patras, A.; Gopisetty, V. V. S.; Vashisht, P.; Ravi, R.

10.1101/2022.02.22.481446 — microbiology — Posted on 2022-02-22

744 VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

Ding, S.; Gong, S. Y.; Grover, J.; Mohammadjavad, M.; Chen, Y.; Vezina, D.; Beaudoin-Bussieres, G.; Verma, V. T.; Goyette, G.; Richard, J.; Yang, D.; Smith, A. B.; Pazgier, M.; Cote, M.; Abrams, C.; Mothes, W.; Finzi, A.; Baron, C.

10.1101/2022.02.03.479007 — microbiology — Posted on 2022-02-22

745 Antibacterial effects of propolis and brood comb extracts on the causative agent of European Foulbrood (Melissococcus plutonius) in honey bees (Apis mellifera)

Murray, S. K.; Kurkul, C. M.; Mularo, A. J.; Hale, V. L.; Adams, R. M. M.; Johnson, R. M.

10.1101/2022.02.21.481376 — microbiology — Posted on 2022-02-22

746 Cryptic Genes for Interbacterial Antagonism distinguish Rickettsia species Infecting Blacklegged Tick from other Rickettsia pathogens

Verhoeve, V. I.; Fauntleroy, T. D.; Risteen, R. G.; Driscoll, T.; J Gillespie, J.

10.1101/2022.02.21.481368 — microbiology — Posted on 2022-02-22

747 Edible formulations of chicken egg derived IgY antibodies neutralize SarsCoV2 Omicron RBD binding to human ACE2

Meher, K.; Sivakumar, S.; Kadiyala, G.; Iyer, S.; Vangala, S.; Chandran, S.; Saxena, U.

10.1101/2022.02.21.481267 — immunology — Posted on 2022-02-22

748 A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

Yuan, Y.; Gao, X.; Ni, F.; Xie, W.; Fu, W.; Zhang, G.; Hu, H.; Li, Y.; Hu, Q.; Huang, C.; Liu, B.; Liu, Y.; Shen, Q.; Liang, M.

10.1101/2022.02.21.481247 — immunology — Posted on 2022-02-22

749 Activity of the manganese efflux transporter SLC30A10 in dopaminergic but not GABAergic neurons protects against neurotoxicity

Taylor, C. A.; Grant, S.; Jursa, T.; Aschner, M.; Smith, D. R.; Gonzales, R.; Mukhopadhyay, S.

10.1101/2022.02.21.481385 — neuroscience — Posted on 2022-02-22

750 Prepronociceptin-expressing neurons in the extended amygdala signal darting away from an aversive odor

Ung, R. L.; Ortiz-Juza, M. M.; Curtis, V. R.; Alghorazi, R. A.; Velazquez-Hernandez, G.; Ring, A. L.; Garcia-Reyes, R. A.; Stuber, G. D.; Zhou, P.; Kato, H. K.; Pegard, N. C.; Rodriguez-Romaguera, J.

10.1101/2022.02.21.481217 — neuroscience — Posted on 2022-02-22

751 Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

Somaiya, R. D.; Stebbins, K.; Xie, H.; Garcia, A. D. R.; Fox, M.

10.1101/2022.02.22.481508 — neuroscience — Posted on 2022-02-22

752 A Novel Chronic in vivo Oral Cadmium Exposure-Washout Mouse Model for Studying Cadmium Toxicity and Complex Diabetogenic Effects

Wong, W. P. S.; Wang, J. C.; Meyers, M. S.; Wang, N. J.; Sponenburg, R. A.; Allen, N. B.; Edwards, J. E.; El Muayed, M.

10.1101/2022.02.21.481351 — pharmacology and toxicology — Posted on 2022-02-22

753 Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus

Mahajan, A.; Yan, W.; Zidovska, A.; Saintillan, D.; Shelley, M. J.

10.1101/2022.02.22.481494 — biophysics — Posted on 2022-02-22

754 Nucleome Browser: An integrative and multimodal data navigation platform for 4D Nucleome

Zhu, X.; Zhang, Y.; Wang, Y.; Tian, D.; Belmont, A. S.; Swedlow, J. R.; Ma, J.

10.1101/2022.02.21.481225 — bioinformatics — Posted on 2022-02-22

755 Functional networks of the human bromodomain-containing proteins

Gao, C.; Glass, K. C.; Frietze, S. E.

10.1101/2022.02.21.481364 — bioinformatics — Posted on 2022-02-22

756 Supervised Rank aggregation (SRA): A novel rank aggregation approach for ensemble-based feature selection

Jain, R.; Xu, W.

10.1101/2022.02.21.481356 — bioinformatics — Posted on 2022-02-22

757 Multimodal Thrombectomy Device for Treatment of Acute Deep Venous Thrombosis

Ismail, U. N.; Rowe, R. A.; Cashin, J. L.; Genin, G. M.; Zayed, M.

10.1101/2022.02.21.481340 — bioengineering — Posted on 2022-02-22

758 3D bioprinting of an implantable xeno-free vascularized human skin graft

Baltazar, T.; Jiang, B.; Moncayo, A.; Merola, J.; Albanna, M. Z.; Saltzman, W. M.; Pober, J. S.

10.1101/2022.02.21.481363 — bioengineering — Posted on 2022-02-22

759 Nucleosome conformation dictates the histone code

Marunde, M. R.; Fuchs, H. A.; Burg, J. M.; Popova, I. K.; Vaidya, A.; Hall, N. W.; Meiners, M. J.; Watson, R.; Howard, S. A.; Novitzky, K.; McAnarney, E.; Cheek, M. A.; Sun, Z.-W.; Venters, B. J.; Keogh, M.-C.; Musselman, C. A.

10.1101/2022.02.21.481373 — genomics — Posted on 2022-02-22

760 period Translation as a Core Mechanism Controlling Temperature Compensation in an Animal Circadian Clock

Itoh, T. Q.; Yildirim, E.; Surabhi, S.; Braun, R.; Allada, R.

10.1101/2022.02.21.481387 — genetics — Posted on 2022-02-22

761 SexFindR: A computational workflow to identify young and old sex chromosomes

Grayson, P.; Wright, A.; Garroway, C. J.; Docker, M. F.

10.1101/2022.02.21.481346 — evolutionary biology — Posted on 2022-02-22

762 Molecular mechanisms of stress-induced reactivation in mumps virus condensates

Zhang, X.; Sridharan, S.; Zagoriy, I.; Eugster Oegema, C.; Ching, C.; Pflaesterer, T.; Fung, H. K. H.; Poser, I.; Mueller, C. W.; Hyman, A. A.; Savitski, M. M.; Mahamid, J.

10.1101/2021.07.10.451879 — cell biology — Posted on 2022-02-22

763 Estimation of the firing behaviour of a complete motoneuron pool by combining EMG signal decomposition and realistic motoneuron modelling

Caillet, A. H.; Phillips, A. T. M.; Farina, D.; Modenese, L.

10.1101/2022.02.21.481337 — neuroscience — Posted on 2022-02-22

764 Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces

Francis, E. A.; Xiao, H.; Teng, L. H.; Heinrich, V.

10.1101/2022.02.18.481104 — biophysics — Posted on 2022-02-22

765 Novel feature selection methods for construction of accurate epigenetic clocks

Li, A.; Kane, A. E.; Mueller, A.; English, B.; Arena, A.; Vera, D.; Sinclair, D. A.

10.1101/2022.02.21.481326 — bioinformatics — Posted on 2022-02-22

766 Deciphering the tissue-specific regulatory role of intronless genes across cancers

Avina-Padilla, K.; Ramirez-Rafael, J. A.; Herrera-Oropeza, G. E.; Romero, G.; Zambada-Moreno, O.; Gupta, I.; Hernandez-Rosales, M.

10.1101/2022.02.21.481319 — genomics — Posted on 2022-02-22

767 An averaging model for analysis and interpretations of high-order genetic interactions

Katagiri, F.

10.1101/2022.02.21.481332 — genetics — Posted on 2022-02-22

768 Liver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis

Minami, Y.; Hoshino, A.; Higuchi, Y.; Hamaguchi, M.; Kaneko, Y.; Kirita, Y.; Taminishi, S.; Taruno, A.; Fukui, M.; Zoltan, A.; Matoba, S.

10.1101/2022.02.22.481456 — cell biology — Posted on 2022-02-22

769 Sinking the way: a dual role for CCR7 in collective leukocyte migration

Alanko, J.; Ucar, M. C.; Canigova, N.; Stopp, J.; Schwarz, J.; Merrin, J.; Hannezo, E.; Sixt, M.

10.1101/2022.02.22.481445 — cell biology — Posted on 2022-02-22

770 Stability And Shelf-Life Of Plasma Bubbling Treated Cow Milk

Dash, S.; Rangarajan, J.

10.1101/2022.02.18.480824 — microbiology — Posted on 2022-02-22

Simmonite, M.; Peltier, S. J.; Polk, T. A.

10.1101/2022.02.21.481330 — neuroscience — Posted on 2022-02-22

772 Complete sequence of a 641-kb insertion of mitochondrial DNA in the Arabidopsis thaliana nuclear genome

Fields, P. D.; Waneka, G.; Naish, M.; Schatz, M. C.; Henderson, I. R.; Sloan, D. B.

10.1101/2022.02.22.481460 — genomics — Posted on 2022-02-22

773 Zebrafish fin regeneration requires generic and regeneration-specific responses of osteoblasts to trauma

Sehring, I. M.; Haffner-Luntzer, M.; Ignatius, A.; Huber-Lang, M.; Weidinger, G.

10.1101/2022.02.22.481466 — developmental biology — Posted on 2022-02-22

774 Estrogen suppresses DMRT1 expression during ovarian development in the chicken

Zhao, D.; Liu, L.; Nandi, S.; Ioannidis, J.; Yang, X.; Gong, D.; McGrew, M.; Clinton, M.

10.1101/2022.02.22.481469 — developmental biology — Posted on 2022-02-22

775 GPX4-associated Sedaghatian Type Spondylometaphyseal Dysplasia: A Protein Interactome Perspective

Karunakaran, K. B.; Balakrishnan, N.; Ganapathiraju, M.

10.1101/2022.02.17.479371 — developmental biology — Posted on 2022-02-22

776 Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Progeria

Mao, X.; Xiong, Z.-M.; Xue, H.; Brown, M.; Gete, Y. G.; Yu, R.; Sun, L.; Cao, K.

10.1101/2022.02.22.481406 — developmental biology — Posted on 2022-02-22

777 Katnip is required to maintain microtubule function and lysosomal delivery to autophagosomes and phagosomes

Starling, G. P.; Phillips, B. A.; Ganesh, S.; King, J. S.

10.1101/2022.02.22.481453 — cell biology — Posted on 2022-02-22

778 Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved Fluorescence Correlation Spectroscopy

Barbiero, M.; Cirillo, L.; Veerapathiran, S.; Coates, C.; Ruffilli, C.; Pines, J.

10.1101/2022.02.22.481435 — cell biology — Posted on 2022-02-22

779 Development of a physiological insulin resistance model in human stem cell-derived adipocytes

Friesen, M.; Khalil, A. S.; Barrasa, M. I.; Jeppesen, J. F.; Mooney, D.; Jaenisch, R.

10.1101/2022.02.22.481495 — cell biology — Posted on 2022-02-22

780 Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

Mehl, J. L.; Earle, A.; Lammerding, J.; Mhlanga, M.; Vogel, V.; Jain, N.

10.1101/2022.02.22.481454 — cell biology — Posted on 2022-02-22

781 Comprehensive transcriptional profiling and mouse phenotyping reveals dispensable role for adipose tissue selective long noncoding RNA Gm15551

Engelhard, C. A.; Huang, C.; Khani, S.; Kasparek, P.; Prochazka, J.; Rozman, J.; Reguera, D. P.; Sedlacek, R.; Kornfeld, J.-W.

10.1101/2021.12.17.473160 — molecular biology — Posted on 2022-02-22

782 Household transmission of SARS-CoV-2 from humans to pets in Washington and Idaho: burden and risk factors

Meisner, J.; Baszler, T.; Kuehl, K.; Ramirez, V.; Baines, A.; Frisbie, L.; Lofgren, E.; DeAvila, D.; Wolking, R.; Bradway, D.; Wilson, H.; Lipton, B.; Kawakami, V.; Rabinowitz, P.

10.1101/2021.04.24.440952 — microbiology — Posted on 2022-02-22

783 Visual category representations in the infant brain

Xie, S.; Hoehl, S.; Moeskops, M.; Kayhan, E.; Kliesch, C.; Turtleton, B.; Koester, M.; Cichy, R. M.

10.1101/2021.11.03.466293 — neuroscience — Posted on 2022-02-22

784 Potential autoimmunity resulting from molecular mimicry between SARS-CoV-2 Spike and human proteins

Nunez-Castilla, J.; Stebliankin, V.; Baral, P.; Balbin, C. A.; Sobhan, M.; Cickovski, T.; Mondal, A. M.; Narasimhan, G.; Chapagain, P.; Mathee, K.; Siltberg-Liberles, J.

10.1101/2021.08.10.455737 — bioinformatics — Posted on 2022-02-22

785 Evaluation of methods for estimating coalescence times using ancestral recombination graphs

Y C Brandt, D.; Wei, X.; Deng, Y.; Vaughn, A. H.; Nielsen, R.

10.1101/2021.11.15.468686 — genomics — Posted on 2022-02-22

786 Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection

Guarnieri, J. W.; Dybas, J. M.; Fazelinia, H.; Kim, M. S.; Frere, J.; Zhang, Y.; Albrecht, Y. S.; Murdock, D. G.; Angelin, A.; Singh, L. N.; Weiss, S. L.; Best, S. M.; Lott, M. T.; Cope, H.; Zaksas, V.; Saravia-Butler, A.; Meydan, C.; Foox, J.; Mozsary, C.; Kidane, Y. H.; Priebe, W.; Emmett, M.; Meller, R.; Singh, U.; Bram, Y.; tenOever, B. R.; Heise, M. T.; Moorman, N. J.; Madden, E. A.; Taft-Benz, S. A.; Anderson, E. J.; Sanders, W. A.; Dickmander, R. J.; Baxter, V. K.; Baylin, S.; Wurtele, E.; Moraes-vieira, P.; Taylor, D.; Mason, C.; Schisler, J. C.; Schwartz, R. E.; Beheshti, A.; Wallace,

10.1101/2022.02.19.481089 — molecular biology — Posted on 2022-02-22

787 Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

Benlarbi, M.; Laroche, G.; Fink, C.; Fu, K.; Mulloy, R. P.; Phan, A.; Ariana, A.; Stewart, C. M.; Prevost, J.; Beaudoin-Bussieres, G.; Daniel, R.; Bo, Y.; Yockell-Lelievre, J.; Stanford, W. L.; Giguere, P. M.; Mubareka, S.; Finzi, A.; Dekaban, G. A.; Dikeakos, J. D.; Cote, M.

10.1101/2022.02.19.481107 — microbiology — Posted on 2022-02-22

788 Omicron booster in ancestral strain vaccinated mouse augments protective immunities against both the Delta and Omicron variants

Jia, L.; Zhou, Y.; Li, S.; Zhang, Y.; Yan, D.; Wang, W.; Zhang, W.; Wan, Y. m.; Qiu, C.

10.1101/2022.02.19.481110 — immunology — Posted on 2022-02-22

789 Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Goel, R. R.; Painter, M. M.; Lundgreen, K. A.; Apostolidis, S. A.; Baxter, A. E.; Giles, J. R.; Mathew, D.; Pattekar, A.; Reynaldi, A.; Khoury, D. S.; Gouma, S.; Hicks, P.; Dysinger, S.; Hicks, A.; Sharma, H.; Herring, S.; Korte, S.; KC, W.; Oldridge, D. A.; Erickson, R. I.; Weirick, M. E.; McAllister, C. M.; Awofolaju, M.; Tanenbaum, N.; Dougherty, J.; Long, S.; D'Andrea, K.; Hamilton, J. T.; McLaughlin, M.; Williams, J. C.; Adamski, S.; Kuthuru, O.; Drapeau, E. M.; Davenport, M. P.; Hensley, S. E.; Bates, P.; Greenplate, A. R.; Wherry, E. J.

10.1101/2022.02.20.481163 — immunology — Posted on 2022-02-22

790 Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

Nersisyan, S.; Zhiyanov, A.; Zakharova, M.; Ishina, I.; Kurbatskaia, I.; Mamedov, A.; Galatenko, A.; Shkurnikov, M.; Gabibov, A.; Tonevitsky, A.

10.1101/2022.02.21.481175 — immunology — Posted on 2022-02-22

791 SARS-CoV-2 Viroporins Activate The NLRP3-Inflammasome Via The Mitochondrial Permeability Transition Pore

Guarnieri, J. W.; Angelin, A.; Murdoch, D. G.; Portluri, P.; Lie, T.; Wallace, D. C.

10.1101/2022.02.19.481139 — immunology — Posted on 2022-02-22

792 Long-read RNA sequencing identifies polyadenylation elongation and differential transcript usage of host transcripts during SARS-CoV-2 in vitro infection

Chang, J. J.-Y.; Gleeson, J.; Rawlinson, D.; Pitt, M. E.; De Paoli-Iseppi, R.; Zhou, C.; Mordant, F. L.; Londrigan, S. L.; Clark, M. B.; Subbarao, K.; Stinear, T. P.; Coin, L. J. M.

10.1101/2021.12.14.472725 — immunology — Posted on 2022-02-22

793 Clock time: a foreign measure to brain dynamics

van Bree, S.; Melcon, M.; Kolibius, L. D.; Kerren, C.; Wimber, M.; Hanslmayr, S.

10.1101/2021.06.09.447763 — neuroscience — Posted on 2022-02-22

794 Granulocyte Colony Stimulating Factor causes cerebellar deficits and anxiety in a mouse model of CSF-1 receptor-related leukoencephalopathy

Stanley, E. R.; Biundo, F.; Chitu, V.; Tindi, J.; Burghardt, N. S.; Shlager, G. G. L.; Ketchum, H. C.; DeTure, M. A.; Dickson, D. W.; Wszolek, Z. K.; Khodakhah, K.

10.1101/2022.02.21.481325 — neuroscience — Posted on 2022-02-22

795 Response dynamics of spiking network models to incoming seizure-like perturbation.

Depannemaecker, D.; Carlu, M.; Destexhe, A.

10.1101/2022.02.21.481321 — neuroscience — Posted on 2022-02-22

796 Brain-heart dynamics in emotional regulation under uncertainty indexes depressive risk

Chan, H.-L.; Kanayama, N.; Mizuochi, R.; Yamawaki, S.; Machizawa, M. G.

10.1101/2021.12.06.471520 — neuroscience — Posted on 2022-02-22

797 Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2

Dicks, M. D. J.; Rose, L. M.; Bowman, L. A. H.; Graham, C.; Doores, K. J.; Malim, M. H.; Draper, S. J.; Howarth, M.; Biswas, S.

10.1101/2022.02.20.480711 — bioengineering — Posted on 2022-02-22

798 Discovering genomic regions associated with the phenotypic differentiation of European local pig breeds

Poklukar, K.; Mestre, C.; Skrlep, M.; Candek-Potokar, M.; Ovilo, C.; Fontanesi, L.; Riquet, J.; Bovo, S.; Schiavo, G.; Ribani, A.; Munoz, M.; Bozzi, R.; Charneca, R.; Quintanilla, R.; Kusec, G.; Mercat, M.-J.; Zimmer, C.; Razmaite, V.; Araujo, J. P.; Radovic, C.; Karolyi, D.; Servin, B.

10.1101/2022.02.22.481248 — genetics — Posted on 2022-02-22

799 The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: the case of the spike A222V mutation

Ginex, T.; Marco-Marin, C.; Wieczor, M.; P. Mata, C.; Krieger, J.; Lopez-Redondo, M. L.; Frances-Gomez, C.; Ruiz-Rodriguez, P.; Melero, R.; Sanchez-Sorzano, C. O.; Martinez, M.; Gougeard, N.; Forcada-Nadal, A.; Zamora-Caballero, S.; Gozalbo-Rovira, R.; Sanz-Frasquet, C.; Bravo, J.; Rubio, V.; Marina, A.; The IBV-Covid19-Pipeline, ; Geller, R.; Comas, I.; Gil, C.; Coscolla, M.; Orozco, M.; Llacer, J. L.; Carazo, J.-M.

10.1101/2021.12.05.471263 — molecular biology — Posted on 2022-02-22

800 Prefrontally Modulated Vagal Tone Inhibits Inflammatory Responses to Prevent Telomere Damage in Healthy Participants

Ask, T. F.; Sutterlin, S.

10.1101/2022.02.17.480574 — neuroscience — Posted on 2022-02-22

801 Human 14-3-3 proteins site-selectively bind the mutational hotspot region of SARS-CoV-2 nucleoprotein modulating its phosphoregulation

Tugaeva, K. V.; Sysoev, A. A.; Kapitonova, A. A.; Smith, J. L. R.; Zhu, P.; Cooley, R. B.; Antson, A. A.; Sluchanko, N. N.

10.1101/2021.12.23.474009 — biochemistry — Posted on 2022-02-22

802 Transcriptional response of a target plant to benzoxazinoid and diterpene allelochemicals highlights commonalities in detoxification

Knoch, E.; Kovacs, J.; Deiber, S.; Shanmuganathan, R.; Serra, N. S.; Becker, C.; Schandry, N.

10.1101/2022.02.21.480921 — plant biology — Posted on 2022-02-22

803 Integrating phylogenetic and functional data in microbiome studies

Douglas, G. M.; Hayes, M. G.; Langille, M. G. I.; Borenstein, E.

10.1101/2022.02.21.480893 — bioinformatics — Posted on 2022-02-22

804 Hormone levels increase in response to video playback in the Siamese fighting fish

Alex, D.; Cardoso, S. D.; Ramos, A.; Goncalves, D.

10.1101/2022.02.20.481239 — animal behavior and cognition — Posted on 2022-02-22

805 Exploring the phycosphere of Emiliania huxleyi: from bloom dynamics to microbiome assembly experiments

Camara dos Reis, M.; Romac, S.; Le Gall, F.; Marie, D.; Frada, M. J.; Koplovitz, G.; Cariou, T.; Henry, N.; de Vargas, C.; Jeanthon, C.

10.1101/2022.02.21.481256 — ecology — Posted on 2022-02-22

806 Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells

Suliman, M.; Case, K. C.; Schmidtke, M. W.; Lazcano, P.; Onu, C. J.; Greenberg, M. L.

10.1101/2022.02.21.481362 — cell biology — Posted on 2022-02-22

807 Reactive microglia and cytokine release entails microtubule remodeling from acentrosomal to centrosomal arrays

Rosito, M.; Sanchini, C.; Gosti, G.; Moreno, M.; De Panfilis, S.; Giubettini, M.; Debellis, D.; Catalano, F.; Peruzzi, G.; Marotta, R.; Indrieri, A.; De Leonibus, E.; Ragozzino, D.; Ruocco, G.; Di Angelantonio, S.; Bartolini, F.

10.1101/2022.02.21.481355 — cell biology — Posted on 2022-02-22

808 Zika virus replicates in the vagina of mice with intact interferon signaling

Lopez, C. A.; Dulson, S. J.; Lazear, H. M.

10.1101/2022.02.21.481392 — microbiology — Posted on 2022-02-22

809 Cross-frequency slow oscillation-spindle coupling in a biophysically realistic thalamocortical neural mass model

Jajcay, N.; Cakan, C.; Obermayer, K.

10.1101/2021.08.29.458101 — neuroscience — Posted on 2022-02-22

810 Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Andreassen, S. N.; Toft-Bertelsen, T. L.; Wardman, J. H.; Villadsen, R.; MacAulay, N.

10.1101/2022.02.21.481301 — neuroscience — Posted on 2022-02-22

811 Visual and auditory cortices represent acoustic speech-related information during silent lip reading

Broehl, F.; Keitel, A.; Kayser, C.

10.1101/2022.02.21.481292 — neuroscience — Posted on 2022-02-22

812 Do we parse the background into separate streams in the cocktail party?

Szalardy, O.; Toth, B.; Farkas, D.; Orosz, G.; Winkler, I.

10.1101/2022.02.21.480990 — neuroscience — Posted on 2022-02-22

813 Cochlear theta activity oscillates in phase opposition during interaural attention

Koehler, M. H. A.; Weisz, N.

10.1101/2022.02.21.481289 — neuroscience — Posted on 2022-02-22

814 A prefrontal to lateral entorhinal pathway disrupts memory.

Hisey, E.; Soderling, S. H.

10.1101/2022.02.21.480888 — neuroscience — Posted on 2022-02-22

815 The psychotomimetic ketamine disrupts the transfer of late sensory information in the corticothalamic network

Qin, Y.; Mahdavi, A.; Bertschy, M.; Anderson, P. M.; Kulikova, S.; Pinault, D.

10.1101/2022.02.21.476564 — neuroscience — Posted on 2022-02-22

816 A novel dimeric FAP-targeting small molecule-radio conjugate with high and prolonged tumour uptake

Galbiati, A.; Zana, A.; Bocci, M.; Millul, J.; Elsayed, A.; Mock, J.; Neri, D.; Cazzamalli, S.

10.1101/2022.02.21.481260 — pharmacology and toxicology — Posted on 2022-02-22

817 Network profiling of hepatocellular carcinoma targets for evidence based pharmacological approach to improve clinical efficacy

Manchukonda, B.; Kumar, A.

10.1101/2022.02.21.481313 — cancer biology — Posted on 2022-02-22

818 TrieDedup: A fast trie-based deduplication algorithm to handle ambiguous bases in high-throughput sequencing

Hu, J.; Luo, S.; Tian, M.; Alt, F. W.; Ye, A. Y.

10.1101/2022.02.20.481170 — bioinformatics — Posted on 2022-02-22

819 The immunopeptidome from a genomic perspective: Establishing immune-relevant regions for cancer vaccine design

Bedran, G.; Wang, T.; Pankanin, D.; Weke, K.; Laird, A.; Battail, C.; Zanzotto, F. M.; Pesquita, C.; Axelson, H.; Rajan, A.; Harrison, D. J.; Palkowski, A.; Pawlik, M.; Parys, M.; O'Neill, R.; Brennan, P. M.; Symeonides, S.; Goodlett, D. R.; Litchfield, K.; Fahraeus, R.; Hupp, T. R.; Kote, S.; Alfaro, J. A.

10.1101/2022.01.13.475872 — bioinformatics — Posted on 2022-02-22

820 Defensive shimmering responses in the giant honeybee Apis dorsata are triggered by dark stimuli moving against a bright background

Vijayan, S.; Warrant, E. J.; Somanathan, H.

10.1101/2022.02.21.481276 — animal behavior and cognition — Posted on 2022-02-22

821 Estimating the distribution of livestock in space and time: a time-series contribution to livestock density mapping

Meisner, J.; Kato, A.; Lemerani, M.; Mwamba Miaka, E.; Ismail Taban, A.; Wakefield, J.; Rowhani-Rahbar, A.; Pigott, D.; Mayer, J.; Rabinowitz, P.

10.1101/2022.02.20.479787 — ecology — Posted on 2022-02-22

822 Seasonal dynamics and polyphenism of butterfly communities in the coastal plains of central Western Ghats, India

Naik, D.; Rao, R. S. P.; Kunte, K.; Mustak, M. S.

10.1101/2022.02.21.478808 — ecology — Posted on 2022-02-22

823 Multi-pulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms

Kesselheim, J.; Siebner, H. R.; Takemi, M.; Christiansen, L.; Karabanov, A. N.

10.1101/2022.02.19.481138 — neuroscience — Posted on 2022-02-22

824 Public volume electron microscopy data: An essential resource to study the brain microvasculature

Bonney, S. K.; Coelho-Santos, V.; Huang, S.-F.; Takeno, M.; Kornfeld, J.; Keller, A.; Shih, A.

10.1101/2022.02.20.481154 — neuroscience — Posted on 2022-02-22

825 A connectome-based model of conscious access in monkey cortex

Klatzmann, U.; Froudist-Walsh, S.; Bliss, D. P.; Theodoni, P.; Mejias, J. F.; Niu, M.; Rapan, L.; Palomero-Gallagher, N.; Sergent, C.; Dehaene, S.; Wang, X.-J.

10.1101/2022.02.20.481230 — neuroscience — Posted on 2022-02-22

826 Vigilance, arousal, and acetylcholine: Optimal control of attention in a simple detection task

Chebolu, S.; Dayan, P.; Lloyd, K.

10.1101/2022.02.20.481204 — neuroscience — Posted on 2022-02-22

827 Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

Kim, S. J.; Woo, Y.; Kim, H. J.; Goo, B. S.; Nhung, T. T. M.; Lee, S.-A.; Suh, B. K.; Mun, D. J.; Kim, J.-H.; Park, S. K.

10.1101/2022.02.21.481264 — neuroscience — Posted on 2022-02-22

828 Distributed network processes account for the majority of variance in localized visual category selectivity

Cocuzza, C. V.; Sanchez-Romero, R.; Ito, T.; Mill, R. D.; Keane, B. P.; Cole, M. W.

10.1101/2022.02.19.481103 — neuroscience — Posted on 2022-02-22

829 Microglial TNFα controls GABAAR plasticity, slow waves and memory consolidation during sleep

Pinto, M. J.; Bizien, L.; Fabre, J. M.; Thukanovic, N.; Lepetz, V.; Henderson, F.; Pujol, M.; Sala, R. W.; Tarpin, T.; Popa, D.; Triller, A.; Lena, C.; Fabre, V.; Bessis, A.

10.1101/2022.02.21.481254 — neuroscience — Posted on 2022-02-22

830 The cellular coding of temperature in the mammalian cortex

Vestergaard, M.; Carta, M.; Poulet, J. F. A.

10.1101/2022.02.21.481299 — neuroscience — Posted on 2022-02-22

831 Novel Mathematical Model Based on Cellular Automata for Study of Alzheimer's Disease Progress

Jafari, N.; Sarbaz, Y.; Ebrahimi-kalan, A.; Golabi, F.

10.1101/2022.02.21.481261 — neuroscience — Posted on 2022-02-22

832 Pattern reinstatement and attentional control: overlapping processes during episodic long-term memory retrieval

Sabo, M.; Schneider, D.

10.1101/2022.02.21.481285 — neuroscience — Posted on 2022-02-22

833 The impact of genetic risk for Alzheimers disease on the structural brain networks of young adults

Mirza-Davies, A.; Foley, S.; Caseras, X.; Baker, E.; Holmans, P.; Escott-Price, V.; Jones, D. K.; Harrison, J. R.; Messaritaki, E.

10.1101/2021.09.22.461338 — neuroscience — Posted on 2022-02-22

834 Data-Driven Flow-Map Models for Data-Efficient Discovery of Dynamics and Fast Uncertainty Quantification of Biological and Biochemical Systems

Makrygiorgos, G.; Berliner, A. J.; Shi, F.; Clark, D. S.; Arkin, A. P.; Mesbah, A.

10.1101/2022.02.19.481146 — systems biology — Posted on 2022-02-22

835 Acute thermal stress elicits interactions between gene expression and alternative splicing in a fish of conservation concern

Thorstensen, M. J.; Turko, A. J.; Heath, D. D.; Jeffries, K. M.; Pitcher, T. E.

10.1101/2022.02.20.481219 — physiology — Posted on 2022-02-22

836 Profiling skeletal muscle-derived secretome with differentiation and acute contractile activity

Bydak, B.; Pierdona, T. M.; Seif, S.; Sidhom, K.; Obi, P. O.; Labouta, H. I.; Gordon, J. W.; Saleem, A.

10.1101/2022.02.20.481208 — physiology — Posted on 2022-02-22

837 GCNA is a histone binding protein required for spermatogonial stem cell maintenance

Ribeiro, J.; Crossan, G. P.

10.1101/2022.02.21.481287 — physiology — Posted on 2022-02-22

838 Natural language signatures of psilocybin microdosing

Sanz, C.; Cavanna, F.; Muller, S.; de la Fuente, L. A.; Zamberlan, F.; Palmucci, M.; Janeckova, L.; Kuchar, M.; Carrillo, F.; Garcia, A. M.; Pallavicini, C.; Tagliazucchi, E.

10.1101/2022.02.20.481177 — pharmacology and toxicology — Posted on 2022-02-22

839 Single-cell Gene Regulation Network Interference by Large-scale Data Integration

Dong, X.; Tang, K.; Xu, Y.; Wei, H.; Han, T.; Wang, C.

10.1101/2022.02.19.481131 — bioinformatics — Posted on 2022-02-22

840 An Improved Linear Mixed Model for Multivariate Genome-Wide Association Studies

Wang, D.; Teng, J.; Zhao, C.; Li, W.; Tang, H.; Fan, X.; Zhang, Q.; Ning, C.

10.1101/2022.02.21.481252 — bioinformatics — Posted on 2022-02-22

841 Assessing evidence accumulation and rule learning in humans with an online game

Do, Q.; Kane, G. A.; McGuire, J. T.; Scott, B. B.

10.1101/2022.02.19.481071 — animal behavior and cognition — Posted on 2022-02-22

842 Steering clear of the confusion effect: aerial predators target fixed points in dense prey aggregations

Brighton, C. H.; Kloepper, L. N.; Larkman, L.; Zusi, L.; McGowan, K.; Taylor, G. K.

10.1101/2022.02.19.481128 — animal behavior and cognition — Posted on 2022-02-22

843 Effects of Experimental Design, Genetic Architecture and Threshold on Power and False Positive Rate of Genome-Wide Association Studies

Loh, Z.; van der Werf, J. H. J.; Clark, S.

10.1101/2022.02.19.481168 — genetics — Posted on 2022-02-22

844 A comprehensive comparison on cell type composition inference for spatial transcriptomics data

Chen, J.; Liu, W.; Luo, T.; Yu, Z.; Jiang, M.; Wen, J.; Gupta, G. P.; Giusti, P.; Zhu, H.; Yang, Y.; Li, Y.

10.1101/2022.02.20.481171 — genetics — Posted on 2022-02-22

845 Joint effect of changing selection and demography on the site frequency spectrum

Jain, K.; Kaushik, S.

10.1101/2022.02.19.481143 — evolutionary biology — Posted on 2022-02-22

846 Weak selection and the separation of eco-evo time scales using perturbation analysis

Gerlee, P.

10.1101/2021.09.14.460209 — evolutionary biology — Posted on 2022-02-22

847 Local adaptation to novel habitats and climatic changes in a wild tomato species via selective sweeps.

Wei, K.; Silva Arias, G. A.; Tellier, A.

10.1101/2021.09.24.461657 — evolutionary biology — Posted on 2022-02-22

848 Close-kin mark-recapture methods to estimate demographic parameters of mosquitoes

Sharma, Y.; Bennett, J. B.; Rasic, G.; Marshall, J. M.

10.1101/2022.02.19.481126 — ecology — Posted on 2022-02-22

849 Climate warming changes synchrony of plants and pollinators

Freimuth, J.; Bossdorf, O.; Scheepens, J. F.; Willems, F. M.

10.1101/2021.01.10.425984 — ecology — Posted on 2022-02-22

850 Quantifying variability in population abundances

Schlemmer, M.

10.1101/2022.02.19.481101 — ecology — Posted on 2022-02-22

851 Competition contributes to both warm and cool range edges

Lyu, S.; Alexander, J. M.

10.1101/2022.02.20.481210 — ecology — Posted on 2022-02-22

852 B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening mediated by pioneering factors

Kaemena, D. F.; Yoshihara, M.; Ashmore, J.; Beniazza, M.; Zhao, S.; Bertenstam, M.; Olariu, V.; Katayama, S.; Okita, K.; Tomlinson, S.; Yusa, K.; Kaji, K.

10.1101/2022.01.04.474927 — cell biology — Posted on 2022-02-22

853 Induction of AmpC-mediated-βlactam resistance requires a single lytic transglycosylase in Agrobacterium tumefaciens

Figueroa-Cuilan, W.; Howell, M.; Richards, C.; Randich, A.; Yadav, A. K.; Cava, F.; Brown, P. J. B.

10.1101/2020.09.10.292490 — microbiology — Posted on 2022-02-22

854 Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant

Ikemura, N.; Taminishi, S.; Inaba, T.; Arimori, T.; Motooka, D.; Katoh, K.; Kirita, Y.; Kirita, Y.; Li, S.; Suzuki, T.; Itoh, Y.; Ozaki, Y.; Nakamura, S.; Matoba, S.; Standley, D. M.; Okamoto, T.; Takagi, J.; Hoshino, A.

10.1101/2021.12.22.473804 — microbiology — Posted on 2022-02-22

855 Examining the Neural Correlates of Error Awareness in a Large fMRI Study

Dali, G.; Brosnan, M. B.; Tiego, J.; Johnson, B.; Bellgrove, M.; Hester, R.

10.1101/2022.01.06.475224 — neuroscience — Posted on 2022-02-22

856 State-dependent representation of mixtures by the olfactory bulb

Adefuin, A. M.; Lindeman, S.; Reinert, J. K.; Fukunaga, I.

10.1101/2021.09.23.461425 — neuroscience — Posted on 2022-02-22

857 Identifying the midline thalamus in humans in vivo

Reeders, P. C.; Rivera N., M. V.; Vertes, R. P.; Mattfeld, A. T.; Allen, T. A.

10.1101/2022.02.20.481099 — neuroscience — Posted on 2022-02-22

858 Voxel-wise Intermodal Coupling Analysis of Two or More Modalities using Local Covariance Decomposition

Hu, F.; Weinstein, S. M.; Baller, E. B.; Valcarcel, A. M.; Adebimpe, A.; Raznahan, A.; Roalf, D. R.; Robert-Fitzgerald, T. E.; Gonzenbach, V.; Gur, R. C.; Gur, R. E.; Vandekar, S.; Detre, J. A.; Linn, K. A.; Alexander-Bloch, A.; Satterthwaite, T. D.; Shinohara, R. T.

10.1101/2022.02.19.481070 — neuroscience — Posted on 2022-02-22

859 Oscillations support short latency co-firing of neurons during human episodic memory formation.

Roux, F.; Parish, G. M.; Chelvarajah, R.; Rollings, D. T.; Sawlani, V.; Hamer, H.; Gollwitzer, S.; Kreiselmeyer, G.; ter Wal, M. J.; Kolibius, L.; Staresina, B.; Wimber, M.; Self, M. W.; Hanslmayr, S.

10.1101/2021.01.28.428480 — neuroscience — Posted on 2022-02-22

860 Virulence strategies of an insect herbivore and oomycete plant pathogen converge on a host E3 SUMO ligase

Liu, S.; Lenoir, C.; Amaro, T.; Rodriguez, P.; Huitema, E.; Bos, J.

10.1101/2020.06.18.159178 — plant biology — Posted on 2022-02-22

861 The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Suchacki, K. J.; Thomas, B. J.; Fyfe, C.; Tavares, A. A. S.; Sulston, R. J.; Lovdel, A.; Woodward, H. J.; Han, X.; Mattiucci, D.; Brain, E. J.; Alcaide-Corral, C. J.; Gray, G. A.; Whitfield, P. D.; Stimson, R. H.; Morton, N. M.; Johnstone, A. M.; Cawthorn, W. P.

10.1101/2022.02.20.481222 — physiology — Posted on 2022-02-22

862 Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes

Ferrandiz, N.; Downie, L.; Starling, G. P.; Royle, S. J.

10.1101/2021.04.23.441091 — cell biology — Posted on 2022-02-22

863 Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Kim, H.; Leng, K.; Park, J.; Sorets, A.; Kim, S.; Shostak, A.; Sturgeon, S.; Neal, E.; McMahon, D. G.; Schrag, M.; Kampmann, M.; Lippmann, E.

10.1101/2022.02.21.481336 — neuroscience — Posted on 2022-02-22

864 Noncontact and high-precision sensing system for piano keys identified fingerprints of virtuosity

Oku, T.; Furuya, S.

10.1101/2022.02.17.480858 — neuroscience — Posted on 2022-02-22

865 The Effect of Genome Graph Expressiveness on the Discrepancy Between Genome Graph Distance and String Set Distance

Qiu, Y.; Kingsford, C.

10.1101/2022.02.18.481102 — bioinformatics — Posted on 2022-02-22

866 Tensor decomposition- and principal component analysis-based unsupervised feature extraction to select more reasonable differentially expressed genes: Optimization of standard deviation versus state-of-art methods

Taguchi, Y.-h.; Turki, T.

10.1101/2022.02.18.481115 — bioinformatics — Posted on 2022-02-22

867 Interpreting how machine learning models make predictions in biological studies

Zhao, Y.; Shao, J.; Asmann, Y. W.

10.1101/2022.02.18.481077 — bioinformatics — Posted on 2022-02-22

868 Using landscape genomics to infer genomic regions involved in environmental adaptation of soybean genebank accessions

Haupt, M.; Schmid, K. J.

10.1101/2022.02.18.480989 — plant biology — Posted on 2022-02-22

869 Joint dimension reduction and clustering analysis for single-cell RNA-seq and spatial transcriptomics data

Liu, W.; Liao, X.; Yang, Y.; Lin, H.; Yeong, J.; Zhou, X.; Shi, X.; Liu, J.

10.1101/2021.12.25.474153 — genomics — Posted on 2022-02-22

870 Catestatin selects for the colonization of antimicrobial-resistant gut bacterial communities

Gonzalez-Davila, P.; Schwalbe, M.; Danewalia, A.; Dalile, B.; Verbeke, K.; Mahata, S. K.; El Aidy, S.

10.1101/2021.10.11.463921 — microbiology — Posted on 2022-02-22

871 Consistent measurement of LAG-3 expression across multiple staining platforms with the 17B4 antibody clone

Wojcik, J. B.; Desai, K.; Avraam, K.; Vandebroek, A.; Dillon, L. M.; Giacomazzi, G.; Rypens, C.; Benci, J.

10.1101/2022.02.21.481075 — pathology — Posted on 2022-02-22

872 Mechanism of transcription modulation by the transcription-repair coupling factor

Paudel, B. P.; Xu, Z.-Q.; Jergic, S.; Oakley, A. J.; Sharma, N.; Brown, S. H.; Bouwer, J. C.; Lewis, P.; Dixon, N. E.; van Oijen, A. M.; Ghodke, H.

10.1101/2021.04.02.438179 — biophysics — Posted on 2022-02-22

873 Mycorrhizal fungi influence disease during epidemics in plant populations

Eck, J. L.; Kytöviita, M.-M.; Laine, A.-L.

10.1101/2021.09.28.462160 — ecology — Posted on 2022-02-22

874 The Zpr-3 antibody recognizes the 320-354 region of Rho and labels both rods and green cones in zebrafish

Gao, P.; Qin, Y.; Qu, Z.; Huang, Y.; Liu, X.; Li, J.; Liu, F.; Liu, M.

10.1101/2022.02.21.481375 — developmental biology — Posted on 2022-02-22

875 The Impact of Protection Measures and Treatment onPneumonia Infection Model

Teklu, S. W.

10.1101/2022.02.21.481255 — developmental biology — Posted on 2022-02-22

876 Quantitative Proteomic Profiling of Murine Embryonic Heart Development Reveals a Role for the Mevalonate Pathway in Cardiomyocyte Proliferation

Edwards, W.; Greco, T. M.; Miner, G. E.; Barker, N. K.; Herring, L. E.; Cohen, S.; Cristea, I. M.; Conlon, F. L.

10.1101/2022.02.21.481309 — developmental biology — Posted on 2022-02-22

877 Molecular Signatures and Cellular Diversity During Mouse Habenula Development

van de Haar, L. L.; Riga, D.; Boer, J.; Adolfs, Y.; Sieburgh, T. E.; van Dijk, R. E.; Watanabe, K. L.; van Kronenburg, N.; Broekhoven, M. H.; Posthuma, D.; Meye, F. J.; Basak, O.; Pasterkamp, R. J.

10.1101/2022.02.21.481251 — developmental biology — Posted on 2022-02-22

878 Proteasomal downregulation of the pro-apoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

Romano, D.; Garcia-Gutierrez, L.; Duffy, D. J.; Flaherty, K.; Frederick, D. T.; Kolch, W.; Matallanas, D.

10.1101/2022.02.21.481296 — molecular biology — Posted on 2022-02-22

879 Cobalamin riboswitches are broadly sensitive to corrinoid cofactors to enable an efficient gene regulatory strategy

Kennedy, K. J.; Widner, F. J.; Sokolovskaya, O. M.; Innocent, V. L.; Procknow, R. R.; Mok, K. C.; Taga, M. E.

10.1101/2022.02.20.481237 — microbiology — Posted on 2022-02-22

880 Drosophila gustatory projections are segregated by taste modality and connectivity

Engert, S.; Sterne, G. R.; Bock, D.; Scott, K.

10.1101/2021.12.08.471796 — neuroscience — Posted on 2022-02-22

881 Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis

Liao, C.-Y.; Pu, Y.; Nolan, T. M.; Montes, C.; Guo, H.; Walley, J.; Yin, Y.; Bassham, D. C.

10.1101/2022.02.21.481334 — plant biology — Posted on 2022-02-22

882 Multigenerational exposure to heat stress induces phenotypic resilience, and genetic and epigenetic variations in Arabidopsis thaliana offspring

Yadav, N. S.; Titov, V.; Ayemere, I.; Byeon, B.; Ilnytskyy, Y.; Kovalchuk, I.

10.1101/2020.11.30.405365 — plant biology — Posted on 2022-02-22

883 LKB1 acts as a critical brake for the glucagon-mediated fasting response

Acevedo-Acevedo, S.; Stefkovich, M. L.; Kang, S. W. S.; Cunningham, R. P.; Cultraro, C. M.; Porat-Shliom, N.

10.1101/2022.01.29.478228 — physiology — Posted on 2022-02-22

884 AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements

Chien, C.-c.; Jiang, J.; Li, T.; Gong, B.; Gaitas, A.

10.1101/2022.02.21.481347 — biophysics — Posted on 2022-02-21

885 Sensitive Spatiotemporal Tracking of Spontaneous Metastasis in Deep Tissues via a Genetically-Encoded Magnetic Resonance Imaging Reporter

Nyström, N. N.; McRae, S. W.; Martinez, F. F.; Kelly, J. J.; Scholl, T. J.; Ronald, J. A.

10.1101/2022.02.09.479610 — bioengineering — Posted on 2022-02-21

886 An inventory of early branch points in microbial phosphonate biosynthesis

Li, S.; Horsman, G. P.

10.1101/2021.04.07.438883 — biochemistry — Posted on 2022-02-21

887 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

Mehta, V.; Khanppnavar, B.; Schuster, D.; Kantarci, I.; Vercellino, I.; Kosturanova, A.; Iype, T.; Stefanic, S.; Picotti, P.; Korkhov, V. M.

10.1101/2021.12.01.470738 — biochemistry — Posted on 2022-02-22

888 Molecular insights into the recognition of acetylated histone modifications by the BRPF2 bromodomain

Barman, S.; Roy, A.; Padhan, J.; Sudhamalla, B.

10.1101/2022.02.20.481182 — biochemistry — Posted on 2022-02-22

889 A Facile Method to Produce N-Terminally Truncated α-Synuclein

Thrush, R. J.; Vadukul, D. M.; Aprile, F. A.

10.1101/2022.02.21.481273 — biochemistry — Posted on 2022-02-22

890 Structural basis for the activation and ligand recognition of the human oxytocin receptor

Waltenspuehl, Y.; Ehrenmann, J.; Vacca, S.; Thom, C.; Medalia, O.; Plueckthun, A.

10.1101/2022.02.21.481286 — biochemistry — Posted on 2022-02-22

891 Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump

Kowalski, A.; Betzer, C.; Larsen, S. T.; Gregersen, E.; Bermejo, M. C.; Jensen, P. H.; Nissen, P.

10.1101/2022.02.21.481193 — biochemistry — Posted on 2022-02-22

892 Middle Eastern Genetic Variation Improves Clinical Annotation of the Human Genome

Ramaswamy, S.; Jain, R.; El Naofal, M.; Halabi, N.; Yaslam, S.; Taylor, A.; Abou Tayoun, A.

10.1101/2021.05.15.444284 — genomics — Posted on 2022-02-22

Wei, J.; Hou, L.; Liu, J.; Gao, S.; Qi, T.; Sun, S.; Wang, Y.

10.1101/2022.02.21.481263 — genetics — Posted on 2022-02-21

894 Construction of a High-Density Genetic Map Based on Large-Scale Marker Development in Coix lacryma-jobi L . Using Specifific-Locus Amplifified Fragment Sequencing (SLAF-seq)

yang, c.; Ban, X.; Zhou, M.; Zhou, Y.; Luo, K.; Yang, X.; Li, Z.; Liu, F.; Li, Q.; Luo, Y.; Zhou, X.; Lei, J.; Long, P.; Wang, J.; Guo, J.

10.1101/2022.02.21.481382 — genetics — Posted on 2022-02-21

895 Landscape diversity and local temperature, but not climate, affect arthropod predation among habitat types

Fricke, U.; Steffan-Dewenter, I.; Zhang, J.; Tobisch, C.; Rojas-Botero, S.; Benjamin, C.; Englmeier, J.; Ganuza, C.; Haensel, M.; Riebl, R.; Uhler, J.; Uphus, L.; Ewald, J.; Kollmann, J.; Redlich, S.

10.1101/2022.02.21.481383 — ecology — Posted on 2022-02-21

896 Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila

Bostock, M. P.; Fernandes, V. M.

10.1101/2022.02.21.481306 — developmental biology — Posted on 2022-02-22

897 Activation of Nedd4L Ubiquitin Ligase by FCHO2-generated Membrane Curvature

Sakamoto, Y.; Uezu, A.; Kikuchi, K.; Suetsugu, S.; Nakanishi, H.

10.1101/2022.02.21.481372 — cell biology — Posted on 2022-02-22

898 Insights into the ribosome function from the structures of non-arrested ribosome nascent chain complexes.

Syroegin, E. A.; Aleksandrova, E. V.; Polikanov, Y. S.

10.1101/2022.02.21.480960 — molecular biology — Posted on 2022-02-21

899 Quantitative genetic study suggests sex-specific genetic architecture for fetal testosterone in a wild mammal

Fishman, R.; Kralj-Fiser, S.; Marglit, S.; Koren, L.; Vortman, Y.

10.1101/2022.02.18.480975 — molecular biology — Posted on 2022-02-21

900 Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Devoucoux, M.; Fort, V.; Khelifi, G.; Xu, J.; Alerasool, N.; Galloy, M.; Wong, N.; Bourriquen, G.; Fradet-Turcotte, A.; Taipale, M.; Hope, K.; Hussein, S. M. I.; Cote, J.

10.1101/2021.03.08.434474 — molecular biology — Posted on 2022-02-21

901 Antisense non-coding transcription represses the PHO5 model gene via remodelling of promoter chromatin structure

Novacic, A.; Menendez, D.; Ljubas, J.; Barbaric, S.; Stutz, F.; Soudet, J.; Stuparevic, I.

10.1101/2022.02.21.481265 — molecular biology — Posted on 2022-02-21

902 Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli

Popella, L.; Jung, J.; Do, P. T.; Barquist, L.; Vogel, J.

10.1101/2022.02.21.481268 — microbiology — Posted on 2022-02-21

903 Influenza A virus agnostic receptor tropism revealed using a novel biological system with terminal sialic acid-knockout cells

Kamiki, H.; Murakami, S.; Nishikaze, T.; Hiono, T.; Igarashi, M.; Furuse, Y.; Matsugo, H.; Ishida, H.; Katayama, M.; Sekine, W.; Muraki, Y.; Takahashi, M.; Takenaka-Uema, A.; Horimoto, T.

10.1101/2022.02.21.481323 — microbiology — Posted on 2022-02-21

904 The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

Caruso, L. B.; Guo, R.; Keith, K.; Madzo, J.; Maestri, D.; Boyle, S.; Wasserman, J.; Kossenkov, A.; Gewurz, B.; Tempera, I.

10.1101/2021.08.05.455214 — microbiology — Posted on 2022-02-21

905 HIV-1 Vpu restricts Fc-mediated effector functions in vivo

Prevost, J.; Anand, S. P.; Rajashekar, J. K.; Richard, J.; Goyette, G.; Medjahed, H.; Gendron-Lepage, G.; Chen, H.-C.; Chen, Y.; Horwitz, J. A.; Grunst, M. W.; Zolla-Pazner, S.; Haynes, B. F.; Burton, D. R.; Flavell, R. A.; Kirchhoff, F.; Hahn, B. H.; Smith, A. B.; Pazgier, M.; Nussenzweig, M. C.; Kumar, P.; Finzi, A.

10.1101/2022.02.21.481308 — microbiology — Posted on 2022-02-22

906 Social framing effects in decision making

Piray, P.; Cools, R.; Toni, I.

10.1101/2021.09.28.462257 — neuroscience — Posted on 2022-02-22

907 Comparison of two sampling, quenching and extraction methods for quantitative yeasts metabolomics

Li, X.; Rovetta, M.; van Dam, P. T. N.; Pabst, M.; Heinemann, M.

10.1101/2022.02.21.481278 — systems biology — Posted on 2022-02-21

908 Decoding mechanism of action and susceptibility to drug candidates from integrated transcriptome and chromatin state

Carraro, C.; Bonaguro, L.; Schulte-Schrepping, J.; Horne, A.; Oestreich, M.; Warnat-Herresthal, S.; Helbing, T.; De Franco, M.; Haendler, K.; Mukherjee, S.; Ulas, T.; Gandin, V.; Goettlich, R.; Aschenbrenner, A.; Schultze, J.; Gatto, B.

10.1101/2022.02.21.481294 — systems biology — Posted on 2022-02-21

909 Macroscopic control of synchronous electrical signaling with chemically-excited gene expression

Garcia Navarrete, M.; Avdovic, M.; Perez Garcia, S.; Ruiz Sanchis, D.; Wabnik, K.

10.1101/2022.01.19.476902 — synthetic biology — Posted on 2022-02-21

910 Outer hair cell electro-mechanical power conversion

Rabbitt, R. D.

10.1101/2021.07.29.454372 — physiology — Posted on 2022-02-21

911 The Inflammatory Role of Milk Fat Globule Epidermal Growth Factor VIII in Angiotensin II Induced Arterial Remodeling

Ni, L.; Liu, L.; Zhu, W.; Telljohann, R.; Zhang, J.; Monticone, R. E.; McCraw, K. R.; Liu, C.; Morrell, C. H.; Garrido-Gil, P.; Labandeira-Garcia, J. L.; Lakatta, E. G.; Wang, M.

10.1101/2021.03.11.434767 — pathology — Posted on 2022-02-21

912 Dynamic plasticity within the EMT spectrum, rather than static mesenchymal traits, drives tumor heterogeneity and metastatic progression of breast cancers

Brown, M. S.; Abdollahi, B.; Wilkins, O. M.; Chakraborty, P.; Ognjenovic, N. B.; Muller, K. E.; Jolly, M. K.; Hassanpour, S.; Pattabiraman, D. R.

10.1101/2021.03.17.434993 — cancer biology — Posted on 2022-02-21

913 Structural and functional determinants inferred from deep mutational scans

Bajaj, P.; Manjunath, K.; Varadarajan, R.

10.1101/2022.02.21.481196 — biophysics — Posted on 2022-02-21

914 Gradients of orientation, composition and hydration of proteins for efficient light collection by the cornea of the horseshoe crab

Spaeker, O.; Taylor, G. J.; Wilts, B.; Slaby, T.; Abdel Rahman, M. A. K.; Scoppola, E.; Schmitt, C. N.; Sztucki, M.; Liu, J.; Bertinetti, L.; Wagermaier, W.; Scholtz, G.; Fratzl, P.; Politi, Y.

10.1101/2022.02.21.481013 — biophysics — Posted on 2022-02-21

915 Mitochondrial mRNA localization is governed by translation kinetics and spatial transport

Arceo, X. G.; Koslover, E. F.; Zid, B. M.; Brown, A. I.

10.1101/2022.02.16.480701 — biophysics — Posted on 2022-02-21

916 A phospholipase assay screen identifies synergistic inhibitors of the P. aeruginosa toxin ExoU

Foulkes, D. M.; McLean, K.; Hermann, A.; Johnson, J.; Winstanley, C.; Berry, N.; Fernig, D.; Kaye, S. B.

10.1101/2022.02.21.481271 — biochemistry — Posted on 2022-02-21

917 Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures

Clairet, C.; LAPALU, N.; Simon, A.; Soyer, J. L.; Viaud, M.; Zehraoui, E.; Dalmais, B.; Fudal, I.; Ponts, N.

10.1101/2021.04.16.439968 — genomics — Posted on 2022-02-21

918 Sex-specific body mass ageing trajectories in adult Asian elephants

Lalande, L. D.; Lummaa, V.; Aung, H. H.; Htut, W.; Nyein, U. K.; Berger, V.; Briga, M.

10.1101/2020.12.17.423208 — evolutionary biology — Posted on 2022-02-21

919 Little hope for the polyploid endemic Pyrenean Larkspur (Delphinium montanum): evidences from population genomics and Ecological Niche Modelling

Salvado, P.; Aymerich Boixader, P.; Parera, J.; Vila Bonfill, A.; Martin, M.; Quelennec, C.; Lewin, J.-M.; Delorme-Hinoux, V.; Bertrand, J. A. M.

10.1101/2021.09.15.460086 — evolutionary biology — Posted on 2022-02-21

920 No robust coexistence in a canonical model of plant-soil feedbacks

Miller, Z. R.; Lechon-Alonso, P.; Allesina, S.

10.1101/2021.10.27.466177 — ecology — Posted on 2022-02-21

921 Cigarette smoke induces pulmonary arterial dysfunction through an imbalance in the guanylyl cyclase redox status.

Sevilla-Montero, J.; Pino-Fadon, J.; Munar-Rubert, O.; Villegas-Esguevillas, M.; Climent, B.; Agro, M.; Choya-Foces, C.; Martinez-Ruiz, A.; Balsa, E.; Munoz, C.; Gomez-Punter, R. M.; Vazquez-Espinosa, E.; Cogolludo, A.; Calzada, M. J.

10.1101/2022.02.21.481310 — cell biology — Posted on 2022-02-21

922 Tyrosine phosphorylation of mitofusin 2 regulates endoplasmic reticulum-mitochondria tethering

Zhang, P.; Ford, K.; Sung, J. H.; Moeller, J.; Suzuki, Y.; Polina, I.; Tachibana, T.; Kusakari, Y.; Cypress, M. W.; Chaput, I.; Drenkova, K.; Landherr, M.; Adaniya, S. M.; Mishra, J.; Mende, U.; Jhun, B. S.; O-Uchi, J.

10.1101/2022.02.21.481295 — cell biology — Posted on 2022-02-21

Wang, J.; Chen, Q.; Wang, X.; Zhao, S.; Deng, H.; Guo, B.; Zhang, C.; Song, X.; Deng, W.; Zhang, S.; Zhang, T.; Ni, H.

10.1101/2022.02.20.481212 — molecular biology — Posted on 2022-02-21

924 Alternate response of Bacillus anthracis atxA and acpA to serum, HCO3- and CO2

Glinert, I.; Bar-David, E.; Ben-Smueal, A.; Sittner, A.; Puni, R.; Laredo, S.; Kobiler, D.; Weiss, S.; Levy, H.

10.1101/2022.02.21.481328 — microbiology — Posted on 2022-02-21

925 Staphylococcus aureus overcomes anaerobe-derived short-chain fatty acid stress via FadX and the CodY regulon

Fletcher, J. R.; Villareal, A. R.; Penningroth, M. R.; Hunter, R. C.

10.1101/2022.02.21.481349 — microbiology — Posted on 2022-02-21

926 Aquatic long-term persistence of Francisella tularensis ssp. holarctica is driven by water temperature and transition to a viable but non-culturable state

Brunet, C. D.; Peyroux, J.; Ponderand, L.; Bouillot, S.; Girard, T.; Faudry, E.; Maurin, M.; Caspar, Y.

10.1101/2022.02.18.480867 — microbiology — Posted on 2022-02-21

927 Cellular barcoding of protozoan pathogens reveals the within-host population dynamics of Toxoplasma gondii host colonization

Wincott, C. J.; Sritharan, G.; Benns, H. J.; Liakath, F. B.; Gilabert-Carbajo, C.; Bunyan, M.; Fairweather, A.; Alves, E.; Andrews, I.; Game, L.; Frickel, E. M.; Tiengwe, C.; Ewald, S. E.; Child, M. A.

10.1101/2020.08.06.239822 — microbiology — Posted on 2022-02-21

928 Checks and balances of the RTG pathway under arginine deprivation and canavanine exposure in Saccharomyces cerevisiae

Druseikis, M. E.; Covo, S.

10.1101/2022.02.21.481281 — microbiology — Posted on 2022-02-21

929 Epstein-Barr virus latency programs dynamically sensitize B-cells to ferroptosis

Burton, E. M.; Voyer, J.; Gewurz, B. E.

10.1101/2022.02.21.481361 — microbiology — Posted on 2022-02-21

930 Gut microbiome disturbances of altricial Blue and Great tit nestlings are countered by continuous microbial inoculations from parental microbiomes

Diez-Mendez, D.; Bodawatta, K. H.; Freiberga, I.; Kleckova, I.; Jonsson, K. A.; Poulsen, M.; Sam, K.

10.1101/2022.02.20.481211 — microbiology — Posted on 2022-02-21

931 Dynamic changes in uterine NK cell subset frequency and function over the menstrual cycle and pregnancy

Whettlock, E. M.; Woon, E. V.; Cuff, A. O.; Browne, B.; Johnson, M. R.; Male, V.

10.1101/2022.02.21.481277 — immunology — Posted on 2022-02-21

932 B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

Hossain, M. A.; Anasti, K.; Watts, B.; Cronin, K.; Kane, A. P.; Edwards, R. J.; Easterhoff, D.; Zhang, J.; Rountree, W.; Ortiz, Y.; Verkoczy, L.; Reth, M.; Alam, S. M.

10.1101/2022.01.14.476215 — immunology — Posted on 2022-02-21

933 Fronto-Parietal Network Segregation Predicts Maintained Processing Speed in the Cognitively Healthy Oldest-old

Sims, S. A.; Faulkner, M. E.; Stewart, P.; Merritt, S.; Rezaei, R. F.; Bharadwaj, P. K.; Franchetti, M. K.; Raichlen, D. A.; Jessup, C. J.; Hishaw, G. A.; Van Etten, E. J.; Trouard, T. P.; Geldmacher, D.; Wadley, V. G.; Alperin, N.; Porges, E. S.; Woods, A. J.; Cohen, R. A.; Levin, B. E.; Rundek, T.; Alexander, G. E.; Visscher, K. M.

10.1101/2021.10.05.463207 — neuroscience — Posted on 2022-02-21

934 Modulation of sleep by trafficking of lipids through the Drosophila blood brain barrier

Artiushin, G.; Li, F.; Sehgal, A.

10.1101/2022.02.17.480875 — neuroscience — Posted on 2022-02-21

935 The cellular architecture of memory modules in Drosophila supports stochastic input integration

Hafez, O. A.; Escribano, B.; Ziegler, R. L.; Hirtz, J. J.; Niebur, E.; Pielage, J.

10.1101/2020.12.06.413500 — neuroscience — Posted on 2022-02-21

936 Structural insight into the individual variability architecture of the functional brain connectome

Sun, L.; Zhao, T.; Liang, X.; Duan, D.; Liu, J.; Chen, Y.; Wang, X.; Liao, X.; Xia, M.; He, Y.

10.1101/2022.02.16.480803 — neuroscience — Posted on 2022-02-21

937 Cadmium-induced endocytosis of the broad spectrum root metal transporter of Arabidopsis

Spielmann, J.; Cointry, V.; Neveu, J.; Vert, G.

10.1101/2022.02.21.481249 — plant biology — Posted on 2022-02-21

938 Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

Avet, C.; Mancini, A.; Breton, B.; Le Gouill, C.; Hauser, A. S.; Normand, C.; Kobayashi, H.; Gross, F.; Hogue, M.; Lukasheva, V.; St-Onge, S.; Carrier, M.; Heroux, M.; Morissette, S.; Fauman, E.; Fortin, J.-P.; Schann, S.; Leroy, X.; Gloriam, D. E.; Bouvier, M.

10.1101/2020.04.20.052027 — pharmacology and toxicology — Posted on 2022-02-21

939 Inhibition of Glycogen Metabolism Induces Reactive Oxygen Species-Dependent Apoptosis in Anaplastic Thyroid Cancer

Davidson, C. D.; Tomczak, J. A.; Amiel, E.; Carr, F. E.

10.1101/2022.02.16.480663 — cancer biology — Posted on 2022-02-21

940 Ectopic FVIII expression and misfolding in hepatocytes as a potential cause of human hepatocellular carcinoma

Kapelanski-Lamoureux, A.; Chen, Z.; Gao, Z.-h.; Deng, R.; Lazaris, A.; Lebeaupin, C.; Giles, L.; Malhotra, J.; Yong, J.; Zou, C.; de Jong, Y. P.; Metrakos, P.; Herzog, R. W.; Kaufman, R. J.

10.1101/2021.01.19.427220 — cancer biology — Posted on 2022-02-21

941 Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation.

Das, B.; Roychowdhury, S.; Mohanty, P.; Rizuan, A.; Mittal, J.; Chattopadhyay, K.

10.1101/2022.02.20.481199 — biophysics — Posted on 2022-02-21

942 Structural insights into the peptide selectivity and activation of human neuromedin U receptors

You, C.; Zhang, Y.; Xu, P.; Huang, S.; Yin, W.; Xu, H. E.; Jiang, Y.

10.1101/2022.02.21.481304 — biophysics — Posted on 2022-02-21

943 Epitopedia: identifying molecular mimicry between pathogens and known immune epitopes

Balbin, C. A.; Nunez-Castilla, J.; Stebliankin, V.; Baral, P.; Sobhan, M.; Cickovski, T.; Mondal, A. M.; Narasimhan, G.; Chapagain, P. P.; Mathee, K.; Siltberg-Liberles, J.

10.1101/2021.08.26.457577 — bioinformatics — Posted on 2022-02-21

944 Soluble extracts from amnion and chorion membranes improve hMSC osteogenic response in a mineralized collagen scaffold

Kolliopoulos, V.; Dewey, M. J.; Polanek, M.; Xu, H.; Harley, B.

10.1101/2022.02.20.481091 — bioengineering — Posted on 2022-02-21

945 Using ultraviolet absorption spectroscopy to study nanoswitches based on non-canonical DNA structures

McCarte, B.; Yeung, O. T.; Speakman, A. J.; Elfick, A.; Dunn, K. E.

10.1101/2021.08.10.455856 — bioengineering — Posted on 2022-02-21

946 Allosteric interactions prime androgen receptor dimerization and activation

Wasmuth, E.; Vanden Broeck, A.; LaClair, J. R.; Hoover, E. A.; Lawrence, K. E.; Paknejad, N.; Pappas, K. J.; Matthies, D.; Wang, B.; Feng, W.; Watson, P. A.; Zinder, J. C.; Karthaus, W.; de la Cruz, M. J.; Hite, R. K.; Manova-Todorova, K.; Yu, Z.; Weintraub, S. T.; Klinge, S.; Sawyers, C.

10.1101/2022.02.20.481229 — biochemistry — Posted on 2022-02-21

947 The beryllium fluoride form of the Na+,K+-ATPase and the intermediates of the functional cycle

Fruergaard, M. U.; Dach, I.; Andersen, J. L.; Ozol, M.; Shahsavar, A.; Quistgaard, E. M.; Poulsen, H.; Fedosova, N. U.; Nissen, P.

10.1101/2021.11.08.467847 — biochemistry — Posted on 2022-02-21

948 PBRM1 is a vulnerability in ARID1A deficient multicellular tumor spheroids

Chakravarty, T.; Tran, K. D.; Dhamecha, D.; Perdue, T.; Garzon, J. L.; Menon, J.; Dutta, A.

10.1101/2022.02.21.481305 — biochemistry — Posted on 2022-02-21

949 Antibacterial potency of Type VI amidase effector toxins is dependent on substrate topology and cellular context

Radkov, A.; Sapiro, A. L.; Flores, S.; Henderson, C.; Saunders, H.; Kim, R.; Massa, S.; Thompson, S.; Mateusiak, C.; Biboy, J.; Zhao, Z.; Starita, L. M.; Hatleberg, W.; Vollmer, W.; Russell, A. B.; Simorre, J.-P.; Anthony-Cahill, S.; Brzovic, P.; Hayes, B.; Chou, S.

10.1101/2022.02.15.480620 — biochemistry — Posted on 2022-02-21

950 From bacteria to plants: a repurposing strategy in the pursuit for novel herbicides

Mackie, E.; Barrow, A.; Giel, M.-C.; Hulett, M. D.; Gendall, A.; Panjikar, S.; Soares da Costa, T.

10.1101/2022.02.20.481218 — biochemistry — Posted on 2022-02-21

951 Pneumococcal within-host diversity during colonisation, transmission and treatment

Tonkin-Hill, G.; Ling, C.; Chaguza, C.; Salter, S. J.; Hinfonthong, P.; Nikolaou, E.; Tate, N.; Pastusiak, A.; Turner, C.; Chewapreecha, C.; Frost, S. D.; Corander, J.; Croucher, N. J.; Turner, P.; Bentley, S. D.

10.1101/2022.02.20.480002 — genomics — Posted on 2022-02-21

952 Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

Hoye, M. L.; Calviello, L.; Poff, A. J.; Ejimogu, N.-E.; Newman, C. R.; ou, j.; Floor, S. N.; Silver, D. L.

10.1101/2022.02.21.481343 — developmental biology — Posted on 2022-02-21

953 Mechanical competition promotes selective listening to receptor inputs to resolve directional dilemmas in neutrophil migration

Hadjitheodorou, A.; Bell, G. R. R.; Ellett, F.; Irimia, D.; Tibshirani, R.; Collins, S. R.; Theriot, J. A.

10.1101/2022.02.21.481331 — cell biology — Posted on 2022-02-21

954 Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks

Küllmer, F.; Veprek, N. A.; Borowiak, M.; Nasufovic, V.; Barutzki, S.; Thorn-Seshold, O.; Arndt, H.-D.; Trauner, D. H.

10.1101/2022.02.21.480923 — cell biology — Posted on 2022-02-21

955 Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of IP6K1 and repression of myo-inositol-3-P synthase

Lazcano, P.; Schmidtke, M. W.; Onu, C. J.; Greenberg, M. L.

10.1101/2022.02.21.481348 — molecular biology — Posted on 2022-02-21

956 Pattern Recognition Receptor for Bacterial Lipopolysaccharide in the Cytosol of Human Macrophages

Rojas-Lopez, M.; Zajac, A. S.; Wood, T. E.; Miller, K. A.; Gil Marques, M. L.; Hachey, A. C.; Kharbanda, V.; Egger, K. T.; Goldberg, M. B.

10.1101/2021.10.22.465470 — microbiology — Posted on 2022-02-21

957 Microbial electrochemical systems for enhanced degradation of glyphosate: Electrochemical performance, degradation efficiency, and analysis of the anodic microbial community

Rafieenia, R.; Mahmoud, M.; El-Gohary, F.; Avignone Rossa, C.

10.1101/2022.02.21.481054 — microbiology — Posted on 2022-02-21

958 Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication

Gullberg, R. C.; Chotiwan, N.; Islam, M. N.; St Clair, L.; Lian, E.; Edwards, T. J.; Khadka, S.; Teng, C.; Graham, B.; Krieger, K.; Hopf-Jannasch, A.; LaCount, D. J.; Belisle, J. T.; Kuhn, R. J.; Perera, R.

10.1101/2022.02.21.481365 — microbiology — Posted on 2022-02-21

959 Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections

van Puffelen, J. H.; Novakovic, B.; van Emst, L.; Kooper, D.; Zuiverloon, T. C. M.; Oldenhof, U. T. H.; Witjes, J. A.; Galesloot, T. E.; Vrieling, A.; Aben, K. K. H.; Kiemeney, L. A. L. M.; Oosterwijk, E.; Netea, M. G.; Boormans, J. L.; van der Heijden, A. G.; Joosten, L. A. B.; Vermeulen, S. H.

10.1101/2022.02.21.480081 — immunology — Posted on 2022-02-21

960 On the Mental Status of Stargazer Mice

Schirmer, C.; Abboud, M. A.; Lee, S. C.; Bass, J. S.; Mazumder, A. G.; Kamen, J. L.; Krishnan, V.

10.1101/2022.02.21.481350 — neuroscience — Posted on 2022-02-21

961 Feed efficiency of lactating Holstein cows was not as repeatable across diets as within diet over subsequent lactation stages

Fischer, A.; Gasnier, P.; faverdin, p.

10.1101/2021.02.10.430560 — zoology — Posted on 2022-02-21

962 Enabling interpretable machine learning for biological data with reliability scores

Ahlquist, K. D.; Sudgen, L.; Ramachandran, S.

10.1101/2022.02.18.481082 — bioinformatics — Posted on 2022-02-21

963 Spontaneous behavioural recovery following stroke relates to the integrity of sensory and association cortices

Nashed, J. Y.; Shearer, K. T.; Wang, J. Z.; Chen, Y.; Cook, E. E.; Champagne, A. A.; Coverdale, N. S.; Frenandez-Ruiz, J.; Gallivan, J. P.; Cook, D. J.

10.1101/2022.02.18.481083 — neuroscience — Posted on 2022-02-21

964 Functional Connections Among Neurons within Single Columns of Macaque V1

Trepka, E.; Zhu, S.; Xia, R.; Chen, X.; Moore, T.

10.1101/2022.02.18.481095 — neuroscience — Posted on 2022-02-21

965 On Periodic Gene Expression in Budding Yeast

Machne, R.; Murray, D. B.; Bernhart, S. H.; Axmann, I. M.; Stadler, P. F.

10.1101/2021.05.26.444658 — cell biology — Posted on 2022-02-21

966 Unsupervised physiological noise correction of fMRI data using phase and magnitude information (PREPAIR)

Bancelin, D.; Bachrata, B.; Bollmann, S.; de Lima Cardoso, P.; Szomolanyi, P.; Trattnig, S.; Robinson, S. D.

10.1101/2022.02.18.480884 — neuroscience — Posted on 2022-02-21

967 Maturation of prefrontal input to dorsal raphe nucleus increases behavioral persistence in mice

Gutierrez-Castellanos, N.; Sarra, D.; Godinho, B.; Mainen, Z.

10.1101/2022.01.01.474690 — neuroscience — Posted on 2022-02-21

968 Circadian regulation of the transcriptome in a complex polyploid crop

Rees, H.; Rusholme-Pilcher, R.; Bailey, P.; Colmer, J.; White, B.; Reynolds, C.; Ward, S. J.; Graham, C. A.; Dantas, L. L. d. B.; Dodd, A. N.; Hall, A.

10.1101/2021.09.30.462369 — plant biology — Posted on 2022-02-21

969 Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing

Sheng, X.; Xia, L.; Conti, D. V.; Haiman, C. A.; Kachuri, L.; Chiang, C. W. K.

10.1101/2022.02.19.481174 — genomics — Posted on 2022-02-21

970 Aquatic long-term persistence of Francisella tularensis ssp. holarctica is driven by water temperature and transition to a viable but non-culturable state

Camille, B. D.; Peyroux, J.; Ponderand, L.; Bouillot, S.; Girard, T.; Faudry, E.; Maurin, M.; Caspar, Y.

10.1101/2022.02.18.480867 — microbiology — Posted on 2022-02-21

971 Fibromodulin Ablation Exacerbates the Severity of Acute DSS Colitis

Halasi, M.; Grinstein, M.; Adini, A.; Adini, I.

10.1101/2022.01.12.475640 — immunology — Posted on 2022-02-21

972 ABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methods

Jones, H. B. L.; Heilig, R.; Davis, S.; Fisher, R.; Kessler, B. M.; Pinto-Fernandez, A.

10.1101/2022.02.18.480987 — biochemistry — Posted on 2022-02-21

973 Chromatin state transition underlies the temporal changes in gene expression during cardiomyocyte maturation

Lin, C.-Y.; Chang, Y.-M.; Tseng, H.-Y.; Shih, Y.-L.; Yeh, H.-H.; Liao, Y.-R.; Hsu, C.-L.; Chen, C.-C.; Yan, Y.-T.; Kao, C.-F.

10.1101/2021.12.28.474318 — developmental biology — Posted on 2022-02-20

974 Creating De Novo Overlapped Genes

Logel, D. Y.; Jaschke, P. R.

10.1101/2022.02.15.480625 — synthetic biology — Posted on 2022-02-20

975 CRSP: Comparative RNA-seq pipeline for species lacking both a reference genome and annotated transcriptome

Bagheri, A.; Dewey, C.; Stewart, R.; Jiang, P.

10.1101/2022.02.04.479193 — bioinformatics — Posted on 2022-02-20

976 Automated phenol-chloroform extraction of high molecular weight genomic DNA for use in long-read single-molecule sequencing.

Liu, A. W.; Villar-Briones, A.; Luscombe, N. M.; Plessy, C.

10.1101/2022.01.26.477939 — genomics — Posted on 2022-02-20

977 Antibiotic Resistance Genes and Taxa Analysis from Mat and Planktonic Microbiomes of Antarctic Lake Fryxell and Lake Bonney, and a Mat-forming Culture of Rhodoferax antarcticus

Tallada, S.; Hall, G.; Barich, D.; Slonczewski, J. L.

10.1101/2021.12.17.473166 — microbiology — Posted on 2022-02-20

978 A new method based on the von Mises-Fisher distribution shows that a minority of liver-localized CD8 T cells display hard-to-detect attraction to Plasmodium-infected hepatocytes

Zenkov, V. S.; O'Connor, J.; Cockburn, I. A.; Ganusov, V. V.

10.1101/2020.12.12.422451 — immunology — Posted on 2022-02-20

979 Arid5a mediates an IL-17-dependent pathway that drives autoimmunity but not antifungal host defense

Taylor, T. C.; Li, Y.; Li, D.-d.; Majumder, S.; McGeachy, M. J.; Biswas, P. S.; Gingras, S.; Gaffen, S.

10.1101/2022.02.14.480386 — immunology — Posted on 2022-02-20

980 Clenbuterol Attenuates Immune Reaction to Lipopolysaccharide and Its Relationship to Anhedonia in Adolescents

Nguyen, T. N. B.; Ely, B. A.; Pick, D.; Patel, M.; Xie, H.; Kim-Schulze, S.; Gabbay, V.

10.1101/2021.08.07.455522 — neuroscience — Posted on 2022-02-20

981 Social framing effects in decision making

Piray, P.; Cools, R.; Toni, I.

10.1101/2021.09.28.462257 — neuroscience — Posted on 2022-02-20

982 Structural insight into the individual variability architecture of the functional human brain connectome

Sun, L.; Zhao, T.; Liang, X.; Duan, D.; Liu, J.; Chen, Y.; Wang, X.; Liao, X.; Xia, M.; He, Y.

10.1101/2022.02.16.480803 — neuroscience — Posted on 2022-02-20

983 Oncogenic protein condensates suppress growth factor perception and modulate drug tolerance

Gonzalez-Martinez, D.; Roth, L.; Mumford, T.; Guan, J.; Huang, B.; Tulpule, A.; Bivona, T. G.; Bugaj, L. J.

10.1101/2022.02.02.478845 — cancer biology — Posted on 2022-02-20

984 Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

Frosi, Y.; Ng, S.; Lin, Y.-C.; Jiang, S.; Ramlan, S. R.; Lama, D.; Verma, C. S.; Asial, I.; Brown, C. J.

10.1101/2022.02.17.480295 — biochemistry — Posted on 2022-02-20

985 Statistical curve models for inferring 3D chromatin architecture

Tuzhilina, E.; Hastie, T.; Segal, M.

10.1101/2022.02.19.481149 — bioinformatics — Posted on 2022-02-20

986 Latitudinal cline does not predict variation in the microbiome of wild Drosophila melanogaster

Henry, L.; Ayroles, J.

10.1101/2022.02.19.481158 — ecology — Posted on 2022-02-20

987 A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing and neurological disorders

Di Pizio, A.; Marvaldi, L.; Birling, M.-C.; Okladnikov, N.; Dupuis, L.; Fainzilber, M.; Rishal, I.

10.1101/2022.02.20.481176 — neuroscience — Posted on 2022-02-20

988 Oral ingestion of the environmental toxicant trichlorethylene in rats induces alterations in the gut microbiome: relevance to idiopathic Parkinson's disease

Ilieva, N. M.; Wallen, Z. D.; De Miranda, B. R.

10.1101/2022.02.19.481161 — pharmacology and toxicology — Posted on 2022-02-20

989 Changes in nanomechanical properties of single neuroblastoma cells as a model for oxygen and glucose deprivation (OGD)

Zielinski, T.; Pabijan, J.; Zapotoczny, B.; Zemla, J.; Wesolowska, J.; Pera, J.; Lekka, M.

10.1101/2022.02.19.481155 — biophysics — Posted on 2022-02-20

990 Cardiac myosin filaments are directly regulated by calcium

Ma, W.; Gong, H.; Qi, L.; Nag, S.; Irving, T.

10.1101/2022.02.19.481172 — biophysics — Posted on 2022-02-20

991 Active muscular hydraulics

Shankar, S.; Mahadevan, L.

10.1101/2022.02.20.481216 — biophysics — Posted on 2022-02-20

992 A conditional survival distribution-based method for censored data imputation: overcoming the hurdle in machine learning-based survival analysis

Wang, Y.; Li, Z.; Huang, X.; Flowers, C. R.

10.1101/2022.02.18.481114 — bioinformatics — Posted on 2022-02-20

993 Vasor: Accurate prediction of variant effects for amino acid substitutions in MDR3

Behrendt, A.; Golchin, P.; Koenig, F.; Mulnaes, D.; Stalke, A.; Droege, C.; Keitel, V.; Gohlke, H.

10.1101/2022.02.20.481206 — bioinformatics — Posted on 2022-02-20

994 Genome assembly and isoform analysis of a highly heterozygous New Zealand fisheries species, the tarakihi (Nemadactylus macropterus)

Papa, Y.; Wellenreuther, M.; Morrison, M. A.; Ritchie, P. A.

10.1101/2022.02.19.481167 — genomics — Posted on 2022-02-20

995 Weighting by Gene Tree Uncertainty Improves Accuracy of Quartet-based Species Trees

Zhang, C.; Mirarab, S.

10.1101/2022.02.19.481132 — evolutionary biology — Posted on 2022-02-20

996 High retention of genomic variation and fitness-related traits in the effective population of reintroduced wolves in Yellowstone National Park

vonHoldt, B.; DeCandia, A. L.; Cassidy, K. A.; Stahler, E. E.; Sinsheimer, J. S.; Smith, D. W.; Stahler, D. R.

10.1101/2022.02.18.481090 — evolutionary biology — Posted on 2022-02-20

997 Coupling of metataxonomics and culturing improves description of bacterial communities from a multi-contaminated waste sediment and identifies a novel Rhizorhapis sp. with metal resistance potential

Siles, J. A.; Hendrickson, A. J.; Terry, N.

10.1101/2022.02.20.481181 — microbiology — Posted on 2022-02-20

998 Combined single-cell RNA-seq profiling and enhancer editing reveals critical spatiotemporal controls over thalamic nuclei formation in the murine embryo

Govek, K. W.; Chen, S.; Sgourdou, P.; Yao, Y.; Woodhouse, S.; Chen, T.; Fuccillo, M. V.; Epstein, D. J.; Camara, P. G.

10.1101/2022.02.18.481097 — neuroscience — Posted on 2022-02-20

999 Urocortin-3 neurons in the perifornical area mediate the impact of chronic stress on female infant-directed behavior

Autry, A. E.; Abdelmesih, B.; Carta, I.; Anderson, R.

10.1101/2022.02.19.481074 — neuroscience — Posted on 2022-02-20

1000 Synaptic Location Is a Determinant of the Detrimental Effects of α-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala

Nagaraja, C.; Chen, L.; Daniels, S.; Meyerdirk, L.; Steiner, J. A.; Galvis, M. L. E.; Henderson, M.; Brundin, P.; Chu, H.-y.

10.1101/2022.02.20.481207 — neuroscience — Posted on 2022-02-20

1001 Kir6.2-containing KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology

Grizzanti, J.; Moritz, W. R.; Pait, M. C.; Stanley, M.; Kaye, S. D.; Carroll, C. M.; Constantino, N. J.; Deitelzweig, L. T.; Nicol, N. I.; Snipes, J. A.; Kellar, D.; Caesar, E. E.; Dhillon, J.; Remedi, M. S.; Karch, C.; Nichols, C. G.; Holtzman, D. M.; Macauley, S. L.

10.1101/2022.02.20.481215 — neuroscience — Posted on 2022-02-20

1002 Brachypodium antifreeze protein gene products inhibit ice recrystallization, attenuate ice nucleation, and reduce immune response

Juurakko, C. L.; diCenzo, G. C.; Walker, V. K.

10.1101/2022.02.18.480559 — plant biology — Posted on 2022-02-20

1003 Generation of human nociceptor-enriched sensory neurons for the study of pain-related dysfunctions

Holzer, A.-K.; Karreman, C.; Suciu, I.; Furmanowsky, L.-S.; Wohlfarth, H.; Loser, D.; Dirks, W. G.; Gonzalez, E. P.; Leist, M.

10.1101/2022.02.19.480828 — pharmacology and toxicology — Posted on 2022-02-20

1004 A pipeline for natural small molecule inhibitors of endoplasmic reticulum stress

Correia da Silva, D.; Valentao, P.; Andrade, P.; Pereira, D. M.

10.1101/2022.02.20.481203 — pharmacology and toxicology — Posted on 2022-02-20

1005 Increased Relative Biological Effectiveness of Orthovoltage X-rays Compared to γ-rays in Preclinical Irradiation

Bell, B. I.; Vercellino, J.; Brodin, N. P.; Velten, C.; Nanduri, L. S. Y.; Tanaka, K. E.; Fang, Y.; Wang, Y.; Macedo, R.; English, J.; Schumacher, M. M.; Duddempudi, P. K.; Asp, P.; Koba, W.; Shajahan, S.; Liu, L.; Tome, W.; Yang, W.-L.; Kolesnick, R.; Guha, C.

10.1101/2022.02.18.480594 — pathology — Posted on 2022-02-20

1006 Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures

Rausch, T.; Snajder, R.; Leger, A.; Simovic, M.; Stegle, O.; Birney, E.; Bonder, M. J.; Ernst, A.; Korbel, J. O.

10.1101/2022.02.20.480758 — cancer biology — Posted on 2022-02-20

1007 Conformational Ensemble of Monomeric α-Synuclein in Aqueous and Crowded Environments as revealed by Markov State Model

Menon, S.; Mondal, J.

10.1101/2022.02.20.481191 — biophysics — Posted on 2022-02-20

1008 Statistical Mechanical theory for spatio-temporal evolution of Intra-tumor heterogeneity in cancers: Analysis of Multiregion sequencing data

Sinha, S.; Li, X.; Thirumalai, D.

10.1101/2022.02.19.481164 — biophysics — Posted on 2022-02-20

1009 Quantitative sequence basis for the E. coli transcriptional regulatory network

Qiu, S.; Lamoureux, C.; Akbari, A.; Palsson, B. O.; Zielinski, D. C.

10.1101/2022.02.20.481200 — bioinformatics — Posted on 2022-02-20

1010 scAnnotate: an automated cell type annotation tool for single-cell RNA-sequencing data

Ji, X.; Tsao, D.; Bai, K.; Tsao, M.; Zhang, X.

10.1101/2022.02.19.481159 — bioinformatics — Posted on 2022-02-20

1011 Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing

Sheng, X.; Xia, L.; Conti, D. V.; Haiman, C. A.; Kachuri, L.; Chiang, C. W. K.

10.1101/2022.02.19.481174 — genomics — Posted on 2022-02-20

1012 Keratinocyte-Associated Protein 3 is a novel gene for adiposity with differential effects in males and females

Szalanczy, A. M.; Goff, E.; Seshie, O.; Deal, A.; Grzybowski, M.; Klotz, J.; Key, C.-C. C.; Geurts, A.; Solberg-Woods, L.

10.1101/2022.02.20.481201 — genetics — Posted on 2022-02-20

1013 When Vibrios Take Flight: A Meta-analysis of Pathogenic Vibrios Species in Wild and Domestic Birds

Ayala, A. J.; Ogbunugafor, C. B.

10.1101/2022.02.19.481111 — ecology — Posted on 2022-02-20

1014 Using landscape genomics to infer genomic regions involved in environmental adaptation of soybean genebank accessions

Haupt, M.; Schmid, K. J.

10.1101/2022.02.18.480989 — plant biology — Posted on 2022-02-20

1015 Measuring brain beats: cardiac-aligned fast fMRI signals

Hermes, D.; Wu, H.; Kerr, A. B.; Wandell, B.

10.1101/2022.02.18.480957 — neuroscience — Posted on 2022-02-20

1016 Use of sugarcane mosaic virus for virus-induced gene silencing in maize

Chung, S. H.; Zhang, S.; Song, H.; Whitham, S. A.; Jander, G.

10.1101/2022.02.20.481188 — plant biology — Posted on 2022-02-20

1017 Acoustic detection and identification of individual rooks in field recordings using multi-task neural networks

Martin, K.; Adam, O.; Obin, N.; Dufour, V.

10.1101/2022.02.19.481011 — biophysics — Posted on 2022-02-20

1018 Spatio-temporal feature based deep neural network for cell lineage analysis in microscopy images

Chen, S.; Paek, A. L.; Lasick, K. A.; Loganathan, S.; Roveda, J.; Li, A.

10.1101/2021.08.28.457873 — bioinformatics — Posted on 2022-02-20

1019 Protein Stability Changes upon Point Mutations Identified with a Gaussian Network Model Simulating Protein Unfolding Behavior

Mishra, S. K.

10.1101/2022.02.17.480818 — bioinformatics — Posted on 2022-02-20

1020 Northward Expansion of Amblyomma americanum (Acari: Ixodidae) into Southern Michigan

Fowler, P. D.; Nguyentran, S.; Quantroche, L. M.; Porter, M.; Kobbekaduwa, V.; Tippin, S.; Miller, G.; Dinh, E.; Foster, E.; Tsao, J.

10.1101/2021.12.31.474651 — ecology — Posted on 2022-02-20

1021 Differential roles of neural crest- and endothelial-derived FOXC2 in trabecular meshwork and Schlemms Canal in glaucomatous pathology

Norden, P. R.; Beckmann, L.; Fang, R.; Ujiie, N.; Cai, Z.; Zhang, X.; Kweon, J.; Liu, T.; Aoto, K.; Quaggin, S. E.; Zhang, H. F.; Kume, T.

10.1101/2022.02.20.481184 — developmental biology — Posted on 2022-02-20

1022 Regulation of Hedgehog Signaling Through Arih2-Mediated Smoothened Ubiquitination and Endoplasmic Reticulum-Associated Degradation

Lv, B.; Zhang, X.-O.; Pazour, G. J.

10.1101/2022.02.20.481183 — cell biology — Posted on 2022-02-20

1023 The effects of brief heat during early booting on reproductive, developmental and physiological performance in common wheat (Triticum aestivum L.)

Xu, J.; Lowe, C.; Hernandez-Leon, S. G.; Dreisigacker, S.; Reynolds, M. P.; Valenzuela-Soto, E. M.; Paul, M. J.; Heuer, S.

10.1101/2022.02.20.481180 — plant biology — Posted on 2022-02-20

1024 Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expression

Junqueira-Neto, S.; Oliveira, A. R.; Marques, J.; Oliveira, P.; Oliveira Fernandes, M. G.; Hespanhol, V.; Barroso, A.; Pinheiro, J.; Souto Moura, C.; Cavadas, B.; Pereira, L.; Adem, B.; Silva, M.; Melo, S. A.; Costa, J. L.; Machado, J. C.

10.1101/2022.02.20.481179 — cancer biology — Posted on 2022-02-20

1025 Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation.

Das, B.; Roychowdhury, S.; Mohanty, P.; Rizuan, A.; Mittal, J.; Chattopadhyay, K.

10.1101/2022.02.20.481199 — biophysics — Posted on 2022-02-20

1026 An assessment of bioinformatics tools for the detection of human endogenous retroviral insertions in short-read genome sequencing data

Bowles, H.; Kabiljo, R.; Jones, A.; Al Khleifat, A.; Quinn, J. P.; Dobson, R. J.; Swanson, C. M.; Al-Chalabi, A.; Iacoangeli, A.

10.1101/2022.02.18.481042 — bioinformatics — Posted on 2022-02-20

1027 Structural and Functional Characterization of Novel Phosphotyrosine Phosphatase Protein from Drosophila Melanogaster (Pupal Retina)

Naz, R.; Iqbal, A.; Saeed, A.; Khan, A.; Shutaywi, M.; VRINCEANU, N.; Cioca, A. L.

10.1101/2022.02.19.481152 — biochemistry — Posted on 2022-02-20

1028 Molecular insights into the recognition of acetylated histone modifications by the BRPF2 bromodomain

Sudhamalla, B.; Barman, S.; Roy, A.; Padhan, J.

10.1101/2022.02.20.481182 — biochemistry — Posted on 2022-02-20

1029 Large-scale comparison of immunoassay- and aptamer-based plasma proteomics through genetics and disease

Hjorleifsson Eldjarn, G.; Ferkingstad, E.; Lund, S. H.; Helgason, H.; Magnusson, O. T.; Halldorsson, B. V.; Olason, P. I.; Zink, F.; Gudjonsson, S. A.; Sveinbjornsson, G.; Magnusson, M. I.; Helgason, A.; Oddsson, A.; Halldorsson, G. H.; Magnusson, M. K.; Saevarsdottir, S.; Eiriksdottir, T.; Masson, G.; Stefansson, H.; Jonsdottir, I.; Holm, H.; Rafnar, T.; Melsted, P.; Saemundsdottir, J.; Norddahl, G. L.; Thorleifsson, G.; Ulfarsson, M.; Gudbjartsson, D. F.; Thorsteinsdottir, U.; Sulem, P.; Stefansson, K.

10.1101/2022.02.18.481034 — genomics — Posted on 2022-02-20

1030 Mitotic bookmarking by CTCF controls selected genes during the fast post-mitotic genome reactivation of ES cells

Chervova, A.; Festuccia, N.; Dubois, A.; Navarro, P.

10.1101/2022.02.20.481195 — genomics — Posted on 2022-02-20

1031 Are profile mixture models over-parameterized?

Banos, H.; Susko, E.; Roger, A. J.

10.1101/2022.02.18.481053 — evolutionary biology — Posted on 2022-02-20

1032 Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of antibiotic resistance by MCR-1 plasmid acquisition

Jangir, P. K.; Yang, Q.; Shaw, L. P.; Caballero, J. D.; Ogunlana, L.; Wheatley, R. M.; Walsh, T. R.; MacLean, C.

10.1101/2022.02.20.481192 — evolutionary biology — Posted on 2022-02-20

1033 Alteration in long noncoding RNAs in response to oxidative stress and ladostigil in SH-SY5Y cells

Zohar, K.; Giladi, E.; Eliyahu, T.; Linial, M.

10.1101/2022.02.20.481187 — cell biology — Posted on 2022-02-20

1034 Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant Escherichia coli sensitivity to previously ineffective antibiotics

Hong, Y.; Qin, J.; Verderosa, A.; Hawas, S.; Zhang, B.; Blaskovich, M. A. T.; Cronan, J.; Totsika, M.

10.1101/2022.02.18.481121 — microbiology — Posted on 2022-02-20

1035 Improved Heat Tolerance in Heat-acclimated Mice: the Probable Role of the PD-L1 Pathway

li, J.; Qiu, M.; Zhou, Y.; Ye, N.; Guo, H.; Zhou, X.; Ding, X.

10.1101/2022.02.20.481185 — immunology — Posted on 2022-02-20

1036 Measuring brain beats: cardiac-aligned fast fMRI signals

Hermes, D.; Wu, H.; Wandell, B.; Kerr, A. B.

10.1101/2022.02.18.480957 — neuroscience — Posted on 2022-02-20

1037 Sample preparation and warping accuracy for correlative multimodal imaging in the mouse olfactory bulb using 2-photon, synchrotron X-ray and volume electron microscopy

Zhang, Y.; Ackels, T.; Pacureanu, A.; Zdora, M.-C.; Bonnin, A.; Schaefer, A. T.; Bosch, C.

10.1101/2022.02.18.481045 — neuroscience — Posted on 2022-02-20

1038 An increase in serial sarcomere number induced via weighted downhill running improves work loop performance in the rat soleus

Hinks, A.; Jacob, K.; Mashouri, P.; Medak, K. D.; Franchi, M. V.; Wright, D. C.; Brown, S. H. M.; Power, G. A.

10.1101/2022.02.18.481073 — physiology — Posted on 2022-02-20

1039 Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

Boot, J.; Rosser, G.; Kancheva, D.; Vinel, C.; Lim, Y. M.; Pomella, N.; Zhang, X.; Guglielmi, L.; Sheer, D.; Barnes, M.; Brandner, S.; Nelander, S.; Movahedi, K.; Marino, S.

10.1101/2022.02.15.480525 — cancer biology — Posted on 2022-02-20

1040 Imaging-based coculture model for high-throughput compound screening in hematological cancers

Herbst, S. A.; Kim, V.; Schitter, E. C.; Bruch, P.-M.; Roider, T.; Liebers, N.; Kolb, C.; Knoll, M.; Lu, J.; Dreger, P.; Müller-Tidow, C.; Zenz, T.; Huber, W.; Dietrich, S.

10.1101/2022.02.18.481065 — cancer biology — Posted on 2022-02-20

1041 Northward Expansion of Amblyomma americanum (Acari: Ixodidae) into Southern Michigan

Fowler, P. D.; Nguyentran, S.; Quantroche, L. M.; Porter, M.; Kobbekaduwa, V.; Tippin, S.; Miller, G.; Dinh, E.; Foster, E.; Tsao, J.

10.1101/2021.12.31.474651 — ecology — Posted on 2022-02-20

1042 How to resolve conflicting conservation objectives: A decision support tool for the global selection of multi-purpose protected areas

Voskamp, A.; Fritz, S. A.; Koecke, V.; Biber, M.; Nogueira-Brockmeyer, T.; Bertzky, B.; Forrest, M.; Gaylard, A.; Goldstein, A.; Henderson, S.; Hickler, T.; Hof, C.; Kastner, T.; Lang, S.; Manning, P.; Mascia, M. B.; McFadden, I. R.; Niamir, A.; Noon, M.; O'Donell, B.; Opel, M.; Schwede, G.; West, P.; Schenck, C.; Boehning-Gaese, K.

10.1101/2022.02.15.480531 — ecology — Posted on 2022-02-20

1043 Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus.

Martin, M.-F.; Maarifi, G.; Abiven, H.; Seffals, M.; Mouchet, N.; Beck, C.; Bodet, C.; Leveque, N.; Arhel, N. J.; Blanchet, F. P.; Simonin, Y.; Nisole, S.

10.1101/2021.08.17.456611 — microbiology — Posted on 2022-02-20

1044 With a pinch of salt: metagenomic insights into Namib Desert salt pan microbial mats and halites reveal functionally adapted and competitive communities

Martinez-Alvarez, L.; Cowan, D. A.; Ramond, J.-B.; Vikram, S.; Leon-Sobrino, C.; Maggs-Kölling, G.

10.1101/2022.02.18.481119 — microbiology — Posted on 2022-02-20

1045 Network communication models narrow the gap between the modular organization of structural and functional brain networks

Seguin, C.; Mansour L, S.; Sporns, O.; Zalesky, A.; Calamante, F.

10.1101/2022.02.18.480871 — neuroscience — Posted on 2022-02-20

1046 New Music System Reveals Spectral Contribution to Statistical Learning

Loui, P.

10.1101/2020.04.29.068163 — neuroscience — Posted on 2022-02-20

1047 ionbot: a novel, innovative and sensitive machine learning approach to LC-MS/MS peptide identification

Degroeve, S.; Gabriels, R.; Velghe, K.; Bouwmeester, R.; Tichshenko, N.; Martens, L.

10.1101/2021.07.02.450686 — bioinformatics — Posted on 2022-02-20

1048 Hybridization and a mixture of small and large-effect loci facilitate adaptive radiation

De-Kayne, R.; Selz, O. M.; Marques, D. A.; Frei, D.; Seehausen, O.; Feulner, P. G. D.

10.1101/2022.02.18.481029 — evolutionary biology — Posted on 2022-02-20

1049 Unsupervised physiological noise correction of fMRI data using phase and magnitude information (PREPAIR)

Bancelin, D.; Bachrata, B.; Bollmann, S.; de Lima Cardoso, P.; Szomolanyi, P.; Trattnig, S.; Robinson, S. D.

10.1101/2022.02.18.480884 — neuroscience — Posted on 2022-02-20

1050 A Methodological Framework to Assess the Accuracy of Virtual Reality Hand-Tracking Systems: A case study with the Oculus Quest 2

Abdlkarim, D.; Di Luca, M.; Aves, P.; Yeo, S.-H.; Miall, C.; Holland, P.; Galea, J. M.

10.1101/2022.02.18.481001 — neuroscience — Posted on 2022-02-20

1051 Cardiac and gastric interoception have distinct neural substrates

Haruki, Y.; Ogawa, K.

10.1101/2022.02.18.480981 — neuroscience — Posted on 2022-02-20

1052 Acute and chronic toxicity of imidacloprid in the pollinator fly, Eristalis tenax

Nagloo, N.; Rigosi, E.; O'Carroll, D. C.

10.1101/2022.02.18.481021 — pharmacology and toxicology — Posted on 2022-02-20

1053 Hyperflexion is unlikely to be the primary cervical spine injury mechanism in accidental head-on rugby tackling

Silvestros, P.; Preatoni, E.; Gill, H. S.; Cazzola, D.

10.1101/2022.02.18.481008 — bioengineering — Posted on 2022-02-20

1054 Description of Life History & Reproductive Size Threshold in Three High Elevation Puya (Bromeliaceae)

Veldhuisen, L. N.; Lino, M. C. G.; Bodine, E.; Aguirre-Santoro, J.; Jabaily, R. S.

10.1101/2022.02.18.480924 — ecology — Posted on 2022-02-20

1055 Prefrontally Modulated Vagal Tone Inhibits Inflammatory Responses to Prevent Telomere Damage in Healthy Participants

Ask, T. F.; Sutterlin, S.

10.1101/2022.02.17.480574 — neuroscience — Posted on 2022-02-20

1056 Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer's disease

Balusu, S.; Horre, K.; Thrupp, N.; Snellinx, A.; Serneels, L.; Chrysidou, I.; Arranz, A. M.; Sierksma, A.; Simren, J.; Karikari, T.; Zetterberg, H.; Chen, W.-T.; Thal, D. R.; Salta, E.; Fiers, M.; De Strooper, B.

10.1101/2022.02.18.480849 — neuroscience — Posted on 2022-02-20

1057 Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism

Gironda, S. C.; Day, S. M.; Clarke, C. W.; Snipes, J. A.; Nicol, N. I.; Kamran, H.; Vaughan, W.; Macauley, S. L.; Weiner, J. L.

10.1101/2022.02.18.481066 — neuroscience — Posted on 2022-02-20

1058 Exploring the link between Parkinson's disease and Diabetes Mellitus in Drosophila

Sanz, F. J.; Solana-Manrique, C.; Lilao-Garzon, J.; Brito-Casillas, Y.; Munoz-Descalzo, S.; Paricio, N.

10.1101/2022.02.18.481049 — neuroscience — Posted on 2022-02-20

1059 Representational dynamics of memories for real-life events

Jeunehomme, O.; Heinen, R.; Stawarczyk, D.; Axmacher, N.; D'Argembeau, A.

10.1101/2022.02.18.480992 — neuroscience — Posted on 2022-02-20

1060 Right atrial mechanism contributes to atrial fibrillation in a canine model of pulmonary arterial hypertension

Liu, Y.; Zhu, X.; Song, Z.; Qin, M.; Xu, C.; Liu, X.

10.1101/2022.02.19.481116 — physiology — Posted on 2022-02-20

1061 Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations

Subramaniam, A.; Sanden, C.; Moura-Castro, L.; Zemaitis, K.; Schmiderer, L.; Backstrom, A.; Arvidsson, E.; Hultmark, S.; Miharada, N.; Paulsson, K.; Fioretos, T.; Larsson, J.

10.1101/2022.02.18.479480 — cancer biology — Posted on 2022-02-20

1062 Reduced sensorimotor beta dynamics could represent a "slowed movement state" in healthy individuals

Leriche, R. B.; Jackson, N.; Peterson, K.; Aspandiar, Z.; Hufnagel, V.; Swann, N. C.

10.1101/2022.02.17.480936 — neuroscience — Posted on 2022-02-20

1063 Active haptic training improves somatosensory-motor feedback control in the motor skills of experts

Hirano, M.; Furuya, S.

10.1101/2022.02.17.480969 — neuroscience — Posted on 2022-02-20

1064 Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

Lutter, L.; van der Wal, M. M.; Brand, E. C.; Maschmeyer, P.; Vastert, B.; Mashreghi, M.-F.; van Loosdregt, J.; van Wijk, F.

10.1101/2022.02.18.480998 — immunology — Posted on 2022-02-20

1065 The impact of familiarity on cortical taste coding

Staszko, S. M.; Boughter, J. D.; Fletcher, M. L.

10.1101/2022.02.17.480922 — neuroscience — Posted on 2022-02-20

1066 The virtual aging brain: a model-driven explanation for cognitive decline in older subjects

Lavanga, M.; Stumme, J.; Yalcinkaya, B. H.; Fousek, J.; Jockwitz, C.; Sheheitli, H.; Bittner, N.; Hashemi, M.; Petkoski, S.; Caspers, S.; Jirsa, V.

10.1101/2022.02.17.480902 — neuroscience — Posted on 2022-02-20

1067 Neuromodulation due to propofol affects anesthetic oscillatory coupling

Soplata, A. E.; McCarthy, M. M.; Adam, E. M.; Purdon, P. L.; Brown, E. N.; Kopell, N.

10.1101/2022.02.17.480766 — neuroscience — Posted on 2022-02-20

1068 Positive and negative effects of land abandonment on butterfly communities revealed by a hierarchical sampling design across climatic regions

Sugimoto, N.; Fukasawa, K.; Asahara, A.; Kasada, M.; Matsuba, M.; Miyashita, T.

10.1101/2021.05.16.444370 — ecology — Posted on 2022-02-20

1069 ERROR MODELLED GENE EXPRESSION ANALYSIS (EMOGEA) PROVIDES A SUPERIOR OVERVIEW OF TIME COURSE RNA-SEQ MEASUREMENTS AND LOW COUNT GENE EXPRESSION

Karakach, T. K.; Taverna, F.; Barra, J.

10.1101/2022.02.18.481000 — bioinformatics — Posted on 2022-02-20

1070 A dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke to the sensorimotor cortex in middle aged male and female mice

Yahn, G. B.; Wasek, B.; Bottiglieri, T.; Malysheva, O.; Caudill, M. A.; Jadavji, N. M.

10.1101/2021.08.17.456684 — neuroscience — Posted on 2022-02-19

1071 Automatic identification and annotation of MYB gene family members in plants

Pucker, B.

10.1101/2021.10.16.464636 — plant biology — Posted on 2022-02-19

1072 Blood Concentrations of Per- and Polyfluoroalkyl Substances are Associated with Lupus-like Autoimmunity in the American Alligator

Guillette, T.; Jackson, T. W.; Guillette, M.; MCCord, J.; Belcher, S. M.

10.1101/2022.02.15.480575 — pharmacology and toxicology — Posted on 2022-02-19

1073 Optimizing multiplexed imaging experimental design through tissue spatial segregation estimation

Bost, P.; Schulz, D.; Engler, S.; Wasserfall, C.; Bodenmiller, B.

10.1101/2021.11.28.470262 — bioinformatics — Posted on 2022-02-19

1074 Single cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson's disease

Khan, A. H.; Lee, L. K.; Smith, D. J.

10.1101/2022.02.18.481079 — neuroscience — Posted on 2022-02-19

1075 Differential binding of salicylic acid, phenolic acid derivatives and co- factors determines the roles of Arabidopsis NPR1 to NPR4 in plant immunity

Konopka, E.; Saur, M.; Pfitzner, A. J. P.; Pfitzner, U. M.

10.1101/2022.02.18.481035 — plant biology — Posted on 2022-02-19

1076 Progressive maturation of the root apical meristem in Arabidopsis thaliana lateral roots

Berthet, B.; Bald, L.; Louveaux, M.; Maizel, A.

10.1101/2022.02.18.481036 — plant biology — Posted on 2022-02-19

1077 Heme overdrive rewires pan-cancer cell metabolism

Adapa, S. R.; Hunter, G.; Amin, N.; Marinescu, C.; Borsky, A.; Sagatys, E.; Sebti, S.; Reuther, G.; Ferreira, G.; Jiang, R.

10.1101/2022.02.18.481061 — cancer biology — Posted on 2022-02-19

1078 Accurate proteome-wide measurement of methionine oxidation in aging mouse brains

Bettinger, J. Q.; Simon, M.; Korotov, A.; Welle, K. A.; Hryhorenko, J. R.; Seluanov, A.; Gorbunova, V.; Ghaemmaghami, S.

10.1101/2022.02.19.481142 — biochemistry — Posted on 2022-02-19

1079 Reproducibility metrics for CRISPR screens

Billmann, M.; Ward, H. N.; Aregger, M.; Costanzo, M.; Andrews, B. J.; Boone, C.; Moffat, J.; Myers, C. L.

10.1101/2022.02.19.480892 — genomics — Posted on 2022-02-19

1080 Evaluating Impacts of Syntenic Block Detection Strategies on Rearrangement Phylogeny Using Mycobacterium tuberculosis Isolates

Elghraoui, A.; Mirarab, S.; Swenson, K. M.; Valafar, F.

10.1101/2022.02.18.481113 — genomics — Posted on 2022-02-19

1081 Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

Carrasquilla, M.; Early, A. M.; Taylor, A. R.; Knudson Ospina, A.; Echeverry, D. F.; Anderson, T. J.; Mancilla, E.; Aponte, S.; Cárdenas, P.; Buckee, C. O.; Rayner, J. C.; Sáenz, F. E.; Neafsey, D. E.; Corredor, V.

10.1101/2022.02.18.480973 — evolutionary biology — Posted on 2022-02-19

1082 Effective infection with dengue virus in experimental neonate and adult mice through intranasal route

li, J.; Qiu, M.; Zhao, L.; Zhang, J.; Wang, Y.; Liu, M.; Hua, D.; Ding, X.; Zhou, X.; Zeng, J.; Yan, H.-C.

10.1101/2022.02.18.481117 — microbiology — Posted on 2022-02-19

1083 Detection of specific uncultured bacteriophages by fluorescence in situ hybridisation in pig microbiome

Jensen Ostenfeld, L.; Munk, P.; Aarestrup, F. M.; Otani, S.

10.1101/2022.02.18.481118 — microbiology — Posted on 2022-02-19

1084 Chemical exploration of a highly selective scaffold with activity against intracellular Mycobacterium tuberculosis

Njikan, S.; Ahmed, S.; Manning, A. J.; Awasthi, D.; Ovechkina, Y.; chowdhury, S.; Butts, A.; Parish, T.

10.1101/2022.02.18.481120 — microbiology — Posted on 2022-02-19

1085 An NKX-COUP-TFII genomic code for mucosal vascular addressins and organ morphogenesis

Dinh, t. t.; Xiang, M.; Rajaraman, A.; Wang, Y.; Salazar, N.; Roper, W.; Rhee, S.; Brulois, K.; O'Hara, E.; Keifel, H.; Dinh, T.; Gonzalez, D.; Bao, E.; Red-Horse, K.; Balogh, P.; Gabris, F.; Gaszner, B.; Berta, G.; Pan, J.; Butcher, E.

10.1101/2022.02.17.480956 — immunology — Posted on 2022-02-19

1086 Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy

Watari, K.; Yamasaki, S.; Tu, H.-Y.; Shikamura, M.; Kamei, T.; Adachi, H.; Tochitani, T.; Kita, Y.; Nakamura, A.; Ueyama, K.; Ono, K.; Morinaga, C.; Matsuyama, T.; Sho, J.; Nakamura, M.; Fujiwara, M.; Hori, Y.; Tanabe, A.; Hirai, R.; Terai, O.; Ohno, O.; Ohara, H.; Hayama, T.; Ikeda, A.; Nukaya, D.; Matsushita, K.; Takahashi, M.; Kishino, A.; Kimura, T.; Kawamata, S.; Mandai, M.; Kuwahara, A.

10.1101/2022.02.18.480968 — neuroscience — Posted on 2022-02-19

1087 Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex

Bachschmid-Romano, L.; Hatsopoulos, N.; Brunel, N.

10.1101/2022.02.19.481140 — neuroscience — Posted on 2022-02-19

1088 Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages

Martinez, J. A.; Delvenne, M.; Henrion, L.; Moreno, F.; Telek, S.; Dusny, C.; Delvigne, F.

10.1101/2022.02.18.480836 — systems biology — Posted on 2022-02-19

1089 Deep learning accurately quantifies plasma cell percentages on CD138-stained bone marrow samples

Fu, F. C.; Guenther, A.; Sakhdari, A.; McKee, T. D.; Xia, D.

10.1101/2022.02.18.481050 — pathology — Posted on 2022-02-19

1090 Alternative c-MYC mRNA transcripts as an additional tool for c-Myc2 and c-MycS production in BL60 tumors.

IBRAHIM, D.; FAUMONT, N.; TROUTAUD, D.; FEUILLARD, J.; DIAB-ASSAF, M.; OULMOUDEN, A.

10.1101/2022.02.18.480896 — cancer biology — Posted on 2022-02-19

1091 Protein profiling of WERI RB1 and etoposide resistant WERI ETOR reveals new insights into topoisomerase inhibitor resistance in retinoblastoma

Kakkassery, V.; Gemoll, T.; Kraemer, M. M.; Sauer, T.; Tura, A.; Ranjbar, M.; Grisanti, S.; Joachim, S. C.; Mergler, S.; Reinhard, J.

10.1101/2022.02.19.479927 — cancer biology — Posted on 2022-02-19

1092 Complete sequences of the velvet worm slime proteins reveal that slime formation is enabled by disulfide bonds and intrinsically disordered regions

Lu, Y.; Sharma, B.; Soon, W. L.; Xiangyan, S.; Zhao, T.; Lim, Y. T.; Sobota, R. M.; Hoon, S.; Pilloni, G.; Usadi, A.; Pervushin, K.; Miserez, A.

10.1101/2022.02.18.480993 — bioengineering — Posted on 2022-02-19

1093 Systematic Evaluation of Different R-loop Mapping Methods: Achieving Consensus, Resolving Discrepancies and Uncovering Distinct Types of RNA:DNA Hybrids

Chen, J.-Y.; Lim, D.-H.; Chen, L.; Zhou, Y.; Zhang, F.; Shao, C.; Zhang, X.; Li, H.; Wang, D.; Zhang, D.-E.; Fu, X.-D.

10.1101/2022.02.18.480986 — genomics — Posted on 2022-02-19

1094 A Chromodomain Mutation Identifies Separable Roles for C. elegans MRG-1 in Germline and Somatic Development

Doronio, C. A.; Ling, H.; Gleason, E. J.; Kelly, W. G.

10.1101/2022.02.19.479917 — genetics — Posted on 2022-02-19

1095 Integrated epigenome and transcriptome analysis of normal and arrested meiotic initiation during mouse spermatogenesis

Zhang, X.; Gunewardena, S.; Wang, N.

10.1101/2022.02.18.481086 — developmental biology — Posted on 2022-02-19

1096 SpheroidAnalyseR - an online platform for analysing data from 3D spheroids or organoids grown in 96-well plates

Barrow, R.; Wilkinson, J. N.; He, Y.; Callaghan, M.; Bruning-Richardson, A.; Dunning, M.; Stead, L. F.

10.1101/2022.02.18.481039 — cell biology — Posted on 2022-02-19

1097 Towards phage therapy for acne vulgaris: Topical application in a mouse model

Rimon, A.; Rakov, C.; Lerer, V.; Sheffer-Levi, S.; Alkalky-Oren, S.; Shlomov, T.; Shasha, L.; Lubin, R.; Coppenhagen-Glazer, S.; Molho-Pessach, V.; Hazan, R.

10.1101/2022.02.19.481124 — microbiology — Posted on 2022-02-19

1098 Structural insights into the assembly and activation of IL-27 signalling complex

Jin, Y.; Fyfe, P. K.; Gardner, S.; Wilmes, S.; Bubeck, D.; Moraga, I.

10.1101/2022.02.18.481027 — immunology — Posted on 2022-02-19

1099 Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

Neuwirt, E.; Magnani, G.; Cikovic, T.; Kostina, A.; Wohrle, S.; Flemming, S.; Fischenich, N. J.; Saller, B. S.; Gorka, O.; Renner, S.; Agarinis, C.; Parker, C.; Boettcher, A.; Farady, C. J.; Backofen, R.; Rodriguez-Franco, M.; Tholen, M.; Reinheckel, T.; Ott, T.; Gross, C. J.; Jost, P. J.; Gross, O.

10.1101/2022.02.19.480941 — immunology — Posted on 2022-02-19

1100 Single-cell immune profiling reveals novel thymus-seeding populations, T cell commitment, and multi-lineage development in the human thymus

Cordes, M.; Cante-Barrett, K.; van den Akker, E. B.; Moretti, F. A.; Kielbasa, S. M.; Vloemans, S.; Garcia-Perez, L.; Teodosio, C.; van Dongen, J. J. M.; Pike-Overzet, K.; Reinders, M. M.; Staal, F. J. T.

10.1101/2022.02.18.481026 — immunology — Posted on 2022-02-19

1101 Larger lesion volume in people with multiple sclerosis is associated with increased transition energies between brain states and decreased entropy of brain activity

Tozlu, C.; Card, S.; Jamison, K.; Gauthier, S.; Kuceyeski, A.

10.1101/2022.02.17.480876 — neuroscience — Posted on 2022-02-19

1102 Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington's disease mouse phenotype

Creus-Muncunill, J.; Mattei, D.; Bons, J.; Ramirez-Jimenez, A. V.; Hamilton, B. W.; Corwin, C.; Chowdhury, S.; Schilling, B.; Ellerby, L.; Ehrlich, M. E.

10.1101/2022.02.18.480944 — neuroscience — Posted on 2022-02-19

1103 Improved pathogen and stress tolerance in tomato mutants of SET domain histone 3 lysine methyltransferases

Bvindi, C.; Lee, S.; Tang, L.; Mickelbart, M. V.; Li, Y.; Mengiste, T.

10.1101/2022.02.19.481141 — plant biology — Posted on 2022-02-19

1104 A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data

Wang, P. Y.; Bartel, D. P.

10.1101/2022.02.17.480958 — bioinformatics — Posted on 2022-02-19

1105 AIscEA: Unsupervised Integration of Single-cell Gene Expression and Chromatin Accessibility via Their Biological Consistency

Jafari, E.; Johnson, T.; Wang, Y.; Liu, Y.; Huang, K.; Wang, Y.

10.1101/2022.02.17.480279 — bioinformatics — Posted on 2022-02-19

1106 Abiotic conditions shape spatial and temporal morphological variation in North American birds

Youngflesh, C.; Saracco, J. F.; Siegel, R. B.; Tingley, M. W.

10.1101/2022.02.17.480905 — ecology — Posted on 2022-02-19

1107 Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

Malhi, H.; Homad, L. J.; Wan, Y.-H.; Poudel, B.; Fiala, B.; Borst, A. J.; Wang, J. Y.; Walkey, C.; Price, J.; Wall, A.; Singh, S.; Moodie, Z.; Handa, S.; Correnti, C.; Stoddard, B. L.; Veesler, D.; Pancera, M.; Olson, J.; King, N. P.; McGuire, A.

10.1101/2022.02.17.480914 — immunology — Posted on 2022-02-19

1108 Probing stress-regulated ordering of the plant cortical microtubule array via a computational approach

Li, J.; Szymanski, D.; Kim, T.

10.1101/2022.02.17.480928 — plant biology — Posted on 2022-02-19

1109 Detection and characterization of circulating microvesicles containing Shiga toxin type 2 (Stx2) in a rat model of Hemolytic Uremic Syndrome

Sacerdoti, F.; Gomez, F.; Jancic, C.; Moretton, M. A.; Chiappetta, D. A.; Ibarra, C.; Amaral, M. M.

10.1101/2022.02.17.480856 — pathology — Posted on 2022-02-19

1110 Integrating Fossil Flowers into the Angiosperm Phylogeny using a Total Evidence Approach

Lopez-Martinez, A. M.; Schoenenberger, J.; von Balthazar, M.; Gonzalez-Martinez, C. A.; Ramirez-Barahona, S.; Sauquet, H.; Magallon, S.

10.1101/2022.02.17.480913 — paleontology — Posted on 2022-02-19

1111 Yclon: Ultrafast clustering of B cell clones from high-throughput immunoglobulin repertoire sequencing data

Gervasio, J.; Ferreira, A.; Felicori, L.

10.1101/2022.02.17.480909 — bioinformatics — Posted on 2022-02-19

1112 Nomograms of Human Hippocampal Volume Shifted by Polygenic Scores

Janahi, M.; Aksman, L. M.; Schott, J.; Altmann, A.

10.1101/2022.02.17.480931 — bioinformatics — Posted on 2022-02-19

1113 First record of anti-predator behavior in the gall-forming aphid Mordwilkoja vagabunda

Legan, A. W.

10.1101/2022.02.16.480690 — animal behavior and cognition — Posted on 2022-02-19

1114 Fisheries genomics of snapper (Chrysophrys auratus) along the western Australian coast

Bertram, A.; Fairclough, D.; Sandoval-Castillo, J.; Brauer, C.; Fowler, A.; Wellenreuther, M.; Beheregaray, L. B.

10.1101/2022.02.17.479830 — genomics — Posted on 2022-02-19

1115 Bayesian inference of phylogeny is robust to substitution model over-parameterization

Fabreti, L.; Höhna, S.

10.1101/2022.02.17.480861 — evolutionary biology — Posted on 2022-02-19

1116 Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

Chang, T.-H.; Gloria, Y. C.; Hellmann, M. J.; Greve, C.-L.; Le Roy, D.; Roger, T.; Kasper, L.; Hube, B.; Pusch, S.; Gow, N.; Sorlie, M.; Tondervik, A.; Moerschbacher, B.; Weber, A. N. R.

10.1101/2022.02.17.479713 — immunology — Posted on 2022-02-19

1117 gamma aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammation

Kang, S.; Liu, L.; Wang, T.; Cannon, M.; Lin, P.; Fan, T. W.- M.; Scott, D. A.; Wu, H.-J. J.; Lane, A. N.; Wang, R.

10.1101/2022.02.17.480926 — immunology — Posted on 2022-02-19

1118 Eurasian Stone-curlews Burhinus oedicnemus breeding in Italy show a remarkable inter and intra-population variability of migratory behaviour

Falchi, V.; Barbon, A.; Catoni, C.; Cerritelli, G.; Cutroneo, A.; Dall'Omo, G.; Dragonetti, M.; Giovacchini, P.; Meschini, A.; Panzarini, L.; Picciau, A.; Giunchi, D.

10.1101/2022.02.17.480878 — zoology — Posted on 2022-02-19

1119 Data-driven modelling captures dynamics of the circadian clock ofNeurospora crassa

Singh, A.; Li, C.; Diernfellner, A. C. R.; Hoefer, T.; Brunner, M.

10.1101/2022.01.24.477555 — systems biology — Posted on 2022-02-19

1120 Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants

Ogawa, S.; Cui, S.; White, A. R. F.; Nelson, D. C.; Yoshida, S.; Shirasu, K.

10.1101/2022.02.17.480806 — plant biology — Posted on 2022-02-19

1121 Regulatory dynamics distinguishing desiccation tolerance strategies within resurrection grasses

St. Aubin, B.; Wai, C. M.; Raju, S. K. K.; Niederhuth, C. E.; VanBuren, R.

10.1101/2022.02.16.480747 — plant biology — Posted on 2022-02-19

1122 A balanced measure shows superior performance of pseudobulk methods over mixed models and pseudoreplication approaches in single-cell RNA-sequencing analysis

Murphy, A. E.; Skene, N. G.

10.1101/2022.02.16.480517 — bioinformatics — Posted on 2022-02-19

1123 Choosing variant interpretation tools for clinical applications: context matters

Aguirre, J.; Padilla, N.; Özkan, S.; Riera, C.; Feliubadalo, L.; de la Cruz, X.

10.1101/2022.02.17.480823 — bioinformatics — Posted on 2022-02-19

1124 DeepMinimizer: A Differentiable Framework for Optimizing Sequence-Specific Minimizer Schemes

Hoang, M.; Zheng, H.; Kingsford, C.

10.1101/2022.02.17.480870 — bioinformatics — Posted on 2022-02-19

1125 Benchmarking methods for detecting differential states between conditions from multi-subject single-cell RNA-seq data

Junttila, S.; Smolander, J.; Elo, L. L.

10.1101/2022.02.16.480662 — bioinformatics — Posted on 2022-02-19

1126 Identification of biological processes and signaling pathways in lactate-treated cancer cells

Qian, Z.; Gu, H.; Chang, T.

10.1101/2022.02.16.480756 — bioinformatics — Posted on 2022-02-19

1127 Photo-electrochemical Stimulation of Neurons With Organic Donor-Acceptor Heterojunctions

Savva, A.; Hama, A.; Herrera-Lopez, G.; Gasparini, N.; Migliaccio, L.; Kawan, M.; Steiner, N.; McCulloch, I.; Baran, D.; Fiumelli, H.; Magistretti, P. J.; Glowacki, E. D.; Inal, S.

10.1101/2022.02.17.480608 — bioengineering — Posted on 2022-02-19

1128 Randomized gates eliminate bias in sort-seq assays

Trippe, B. L.; Huang, B.; DeBenedictis, E. A.; Coventry, B.; Bhattacharya, N.; Yang, K. K.; Baker, D.; Crawford, L.

10.1101/2022.02.17.480881 — bioengineering — Posted on 2022-02-19

1129 Reducing structural non-identifiabilities in upstream bioprocess models using profile-likelihood

Babel, H.; Omar, O.; Paul, A. J.; Baer, J.

10.1101/2022.02.17.480405 — bioengineering — Posted on 2022-02-19

1130 The Development and Evaluation of a Fully Automated Markerless Motion Capture Workflow

Needham, L.; Evans, M.; Wade, L.; Cosker, D. P.; McGuigan, M. P.; Bilzon, J. L.; Colyer, S. L.

10.1101/2022.02.16.480655 — bioengineering — Posted on 2022-02-19

1131 A Model-Based Clustering via Mixture of Bayesian Hierarchical Models with Covariate Adjustment for Detecting Differentially Expressed Genes from Paired Design

Zhang, Y.; Liu, W.; Qiu, W.

10.1101/2022.02.16.480754 — genomics — Posted on 2022-02-19

1132 Can imputation in a European country be improved by local reference panels? The example of France

Herzig, A. F.; Velo-Suarez, L.; Dina, C.; Redon, R.; Deleuze, J.-F.; Genin, E.

10.1101/2022.02.17.480829 — genetics — Posted on 2022-02-19

1133 Reconstruction of hundreds of reference ancestral genomes across the eukaryotic kingdom

Muffato, M.; Louis, A.; Nguyen, N. T. T.; Lucas, J.; Berthelot, C.; Crollius, H. R.

10.1101/2022.02.17.480882 — evolutionary biology — Posted on 2022-02-19

1134 Using "identity by heterozygosity (IBH)" to detect clonemates under prevalent clonal reproduction in multicellular diploids

Yu, L.; Stachowicz, J. J.; DuBois, K.; Reusch, T. B. H.

10.1101/2022.02.16.480681 — evolutionary biology — Posted on 2022-02-19

1135 High variation in handling times confers 35-year stability to predatorfeeding rates despite altered prey abundances and apparent diet proportions

Novak, M.

10.1101/2022.02.16.480773 — ecology — Posted on 2022-02-19

1136 Call count surveys as a tool to monitor habitats occupied by Cheer Pheasants (Catreus wallichii) in Shimla, Himachal Pradesh

Tiwari, S.; Ranganathan, L.; Kumar, S.; Sharma, R.

10.1101/2022.02.17.478413 — ecology — Posted on 2022-02-19

1137 Sex differences in migration timing influence the network structure of avian assemblages at a stopover site

Bellisario, B.; Cardinale, M.; Maggini, I.; Fusani, L.; Carere, C.

10.1101/2022.02.17.480723 — ecology — Posted on 2022-02-19

1138 Comparison of fitness effects in the earthworm Eisenia fetida after exposure to single or multiple anthropogenic pollutants

Holzinger, A.; Mair, M. M.; Luecker, D.; Seidenath, D.; Opel, T.; Langhof, N.; Otti, O.; Feldhaar, H.

10.1101/2022.02.17.480840 — ecology — Posted on 2022-02-19

1139 Noninvasive sampling for comparisons of wildlife microbiomes may be more reliable than sampling trapped animals

Turjeman, S.; Pekarsky, S.; Corl, A.; Kamath, P. L.; Getz, W. M.; Bowie, R. C.; Markin, Y.; Nathan, R.

10.1101/2022.02.17.480865 — ecology — Posted on 2022-02-19

1140 Dense satellite data reveals landscape connectivity decline in the Andes-Amazon region

Murillo-Sandoval, P.; Clerici, N.; Correa-Ayram, C.

10.1101/2022.02.17.480775 — ecology — Posted on 2022-02-19

1141 Species richness and community structure of bats along a forest elevational transect in Papua New Guinea

Sivault, E.; Amick, P. K.; Armstrong, K. N.; Novotny, V.; Sam, K.

10.1101/2022.02.17.480839 — ecology — Posted on 2022-02-19

1142 Inflammatory monocytes promote pyogranuloma formation to counteract Yersinia blockade of host defense

Sorobetea, D.; Matsuda, R.; Peterson, S. T.; Grayczyk, J. P.; Rao, I.; Krespan, E.; Lanza, M.; Assenmacher, C.-A.; Beiting, D. P.; Radaelli, E.; Brodsky, I. E.

10.1101/2022.02.06.479204 — microbiology — Posted on 2022-02-19

1143 Orthogonal Gene Engineering Enables CD8+ T Cells to Control Tumors through a Novel PD-1+ TOX-indifferent Synthetic Effector State

Corria-Osorio, J.; Carmona, S. J.; Stefanidis, E.; Andreatta, M. J.; Muller, T.; Ortiz, Y.; Seijo, B.; Castro, W.; Jimenez-Luna, C.; Scarpellino, L.; Ronet, C.; Spill, A.; Lanitis, E.; Luther, S. A.; Romero, P.; Irving, M.; Coukos, G.

10.1101/2022.02.18.481059 — immunology — Posted on 2022-02-19

1144 Modulation of sleep by trafficking of lipids through the Drosophila blood brain barrier

Artiushin, G.; Li, F.; Sehgal, A.

10.1101/2022.02.17.480875 — neuroscience — Posted on 2022-02-19

1145 Experience-dependent learning and myelin plasticity in individuals with stroke

Rubino, C.; Larssen, B. C.; Chiu, L. K.; Liu, H.; Kraeutner, S. N.; Mahendran, N.; Denyer, R.; Lakhani, B.; Borich, M. R.; Cornelia, L.; Boyd, L. A.

10.1101/2022.02.17.480894 — neuroscience — Posted on 2022-02-19

1146 Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Manea, A. M. G.; Zilverstand, A.; Ugurbil, K.; Heilbronner, S. R.; Zimmermann, J.

10.1101/2021.10.05.463277 — neuroscience — Posted on 2022-02-19

1147 Rapid motor adaptation to bounce perturbations in online Pong game is independent from the visual tilt of the bouncing surface

Mikula, L.; 't Hart, B. M.; Henriques, D. Y. P.

10.1101/2022.02.16.480739 — neuroscience — Posted on 2022-02-19

1148 The durability of long-lasting insecticidal nets treated with and without piperonyl butoxide (PBO) in Uganda.

Mechan, F.; Katureebe, A.; Tuhaise, V.; Mugote, M.; Oruni, A.; Onyige, I.; Bumali, K.; Thornton, J.; Maxwell, K.; Kyohere, M.; Kamya, M. R.; Mutungi, P.; Kigozi, S. P.; Yeka, A.; Opigo, J.; Maiteki-Sebuguzi, C.; Gonahasa, S.; Hemingway, J.; Dorsey, G.; Reimer, L. J.; Staedke, S. G.; Donnelly, M. J.; Lynd, A.

10.1101/2022.02.17.480046 — zoology — Posted on 2022-02-19

1149 Identification of a small molecule, Mebendazole, as a novel ethylene signaling activator reveals a role of ethylene signaling on the regulation of lateral root angles

He, W.; Zhang, L.; Cao, M.; Arakawa, N.; Xiao, Y.; Hou, Y.; Busch, W.

10.1101/2022.02.16.480742 — plant biology — Posted on 2022-02-19

1150 Enhanced photosynthetic efficiency for increased carbon assimilation and woody biomass production in hybrid poplar INRA 717-1B4

Tao, Y.; Chiu, L.-W.; Hoyle, J. W.; Du, J.; Rasmussen, K.; Mellor, P.; Richey, C.; Kuiper, J.; Fried, M.; Dewhirst, R. A.; Zuzow, R.; Tucker, D.; Crites, A.; Orr, G. A.; Heckert, M. J.; Vidal, D. G.; Orosco-Cardenas, M. L.; Hall, M. E.

10.1101/2022.02.16.480797 — plant biology — Posted on 2022-02-19

1151 The brassinosteroid biosynthesis gene TaD11-2A controls grain size and its elite haplotype improves wheat grain yields

Xu, H.; Sun, H.; Dong, J.; Ma, C.; Li, J.; Li, Z.; Wang, Y.; Ji, J.; Hu, X.; Wu, M.; Zhao, C.; Qin, R.; Wu, J.; Ni, F.; Cui, F.; Wu, Y.

10.1101/2022.02.17.480859 — plant biology — Posted on 2022-02-19

1152 Deep phenotyping platform for microscopic plant-pathogen interactions

Douchkov, D. K.; Lueck, S.

10.1101/2022.02.17.480879 — plant biology — Posted on 2022-02-19

1153 Inhibiting Runx1 protects heart function after myocardial infarction

Martin, T. P.; MacDonald, E. A.; Bradley, A.; Watson, H.; Saxena, P.; Rog-Zielinska, E. A.; Fisher, S.; Elbassioni, A. A. M.; Almuzaini, O.; Booth, C.; Campbell, M.; Herzyk, P.; Blyth, K.; Nixon, C.; Zentilin, L.; Berry, C.; Braun, T.; Giacca, M.; McBride, M. W.; Nicklin, S. A.; Cameron, E. R.; Loughrey, C. M.

10.1101/2022.02.17.480749 — pathology — Posted on 2022-02-19

1154 Cohesin mutation sensitizes cancer cells to anti-PD-1 therapy through endogenous retrovirus-mediated PD-L1 upregulation

Han, Y.; Peng, F.; Chang, Y.; Liu, T.; Shen, J.; Chen, Z.; Zhou, P.; Jiang, F.; Xiang, H.; Zhu, H.; Qing, C.; Kong, X.; Ding, J.; Lang, J.-Y.

10.1101/2022.02.19.481125 — cancer biology — Posted on 2022-02-19

1155 PKD-1 Signaling Is Required for the Maintenance of CSCs with Epithelial-mesenchymal Plasticity in Pancreatic Neuroendocrine Tumors

Guo, Y.; Jiang, Y.; Rose, J. B.; Jaskula-Sztul, R.; Hjelmeland, A.; Chen, H.; Ren, B.

10.1101/2022.02.17.480869 — cancer biology — Posted on 2022-02-19

1156 cLD: Rare-variant disequilibrium between genomic regions identifies novel genomic interactions

Wang, D.; He, J.; Perera, D.; Cao, C.; Kossinna, P.; Li, Q.; Zhang, W.; Alexander, P.; Wu, J.; Zhang, Q.

10.1101/2022.02.16.480745 — bioinformatics — Posted on 2022-02-19

1157 Read depth correction for somatic mutations

Anaya, J.; Baras, A. S.

10.1101/2022.02.16.480761 — bioinformatics — Posted on 2022-02-19

1158 Bioframe: Operations on Genomic Intervals in Pandas Dataframes

Open2C, ; Abdennur, N.; Fudenberg, G.; Flyamer, I. M.; Galitsyna, A. A.; Goloborodko, A.; Imakaev, M.; Venev, S. V.

10.1101/2022.02.16.480748 — bioinformatics — Posted on 2022-02-19

1159 modelRxiv: A platform for the distribution, computation and interactive display of models

Harris, K. D.; Hadari, G.; Greenbaum, G.

10.1101/2022.02.16.480599 — ecology — Posted on 2022-02-19

1160 Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

De Silva, N. S.; Nader, G. P. F.; Nadalin, F.; de Azevedo, K.; Couty, M.; Bhargava, A.; Conrad, C.; Maurin, M.; Fouillade, C.; Londono-Vallejo, A.; Behrendt, R.; Gallwitz, L.; Saftig, P.; Herrero Fernandez, B.; Gonzalez-Granado, J. M.; van Niel, G.; Boissonnas, A.; Piel, M.; Manel, N.

10.1101/2022.02.17.480837 — immunology — Posted on 2022-02-19

1161 Interaction mechanism between the HSV-1 glycoprotein B and the antimicrobial peptide Amyloid-β

Bourgade, K.; Frost, E. H.; Dupuis, G.; Witkowski, J. M.; Laurent, B.; Calmettes, C.; Ramassamy, C.; Desroches, M.; Rodrigues, S.; Fulop, T.

10.1101/2022.02.17.480815 — neuroscience — Posted on 2022-02-19

1162 First comprehensive identification of proteins with increased O-GlcNAc levels during pressure overload hypertrophy.

Zhu, W. Z.; Palazzo, T.; Zhou, M.; Olson, H. M.; Pasa-Tolic, L.; Olson, A.

10.1101/2022.02.17.480962 — physiology — Posted on 2022-02-19

1163 Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

Challoner, B. R.; Woolston, A.; Lau, D.; Buzzetti, M.; Fong, C.; Barber, L. J.; Anandappa, G.; Crux, R.; Assiotis, I.; Fenwick, K.; Begum, R.; Begum, D.; Lund, T.; Sivamanoharan, N.; Sansano, H. B.; Domingo-Arada, M.; Tran, A.; Eccles, B.; Ellis, R.; Falk, S.; Hill, M.; Krell, D.; Murugaesu, N.; Nolan, L.; Potter, V.; Saunders, M.; Shiu, K.-K.; Guettler, S.; Alexander, J. L.; Lazare-Iglesias, H.; Kinross, J.; Murphy, J.; von Loga, K.; Cunningham, D.; Chau, I.; Starling, N.; Ruiz-Banobre, J.; Dhillon, T.; Gerlinger, M.

10.1101/2022.02.16.479224 — cancer biology — Posted on 2022-02-19

1164 The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

Yihao, M.; Feng, Q.; Chang, W.; Lv, Y.; Xu, Y.; Chang, J.; Zheng, P.; Yu, S.; Zhang, Z.; Li, Z.; Lin, Q.; Tang, W.; Zhu, D.; Ji, M.; Ren, L.; Wei, Y.; He, G.; Xu, J.

10.1101/2022.02.16.480691 — cancer biology — Posted on 2022-02-19

1165 Modeling Adsorption, Conformation, and Orientation of the Fis1 Tail Anchor at the Mitochondrial Outer Membrane

Ozgur, B.; Dunn, C. D.; Sayar, M.

10.1101/2021.06.29.450436 — biophysics — Posted on 2022-02-19

1166 Assessing Protein Homology Models with Docking Reproducibility

Plonski, A. P.; Reed, S. M.

10.1101/2022.02.17.480964 — bioinformatics — Posted on 2022-02-19

1167 Detecting Cell Contact-dependent Gene Expression from Spatial Transcriptomics Data

Kim, H.; Lövkvist, C.; Martin, P. C. N.; Kim, J.; Won, K. J.

10.1101/2022.02.16.480673 — bioinformatics — Posted on 2022-02-19

1168 CRISPR-Detector: Fast and Accurate Detection, Visualization, and Annotation of Genome Wide Mutations Induced by Gene Editing Events

Huang, L.; Wang, D.; Chen, H.; Hu, J.; Dai, X.; Liu, C.; Li, A.; Shen, X.; Qi, C.; Sun, H.; Zhang, D.; Chen, T.; Jiang, Y.

10.1101/2022.02.16.480781 — bioinformatics — Posted on 2022-02-19

1169 DGMP: Identifying Cancer Driver Genes by Jointing DGCN and MLP from Multi-omics Genomic Data

Zhang, S.-W.; Xu, J.-Y.; Zhang, T.

10.1101/2022.02.16.480791 — bioinformatics — Posted on 2022-02-19

1170 Protein Stability Changes upon Point Mutations Identified with a Gaussian Network Model Simulating Protein Unfolding Behavior

Mishra, S. K.

10.1101/2022.02.17.480818 — bioinformatics — Posted on 2022-02-19

1171 Generating an in vitro gut model with physiologically relevant biophysical mucus properties

McCright, J. C.; Sinha, A.; Maisel, K.

10.1101/2022.02.18.481062 — bioengineering — Posted on 2022-02-19

1172 DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons

Mazza, M. C.; Shuck, S.; Lin, J.; Moxley, M. A.; Termini, J.; Cookson, M. R.; Wilson, M. A.

10.1101/2022.02.18.481064 — biochemistry — Posted on 2022-02-19

1173 Multi-ancestry genome-wide analysis identifies common genetic variants for self-reported sleep duration and shared genetic effects

Scammell, B. H.; Song, Y.; Tchio, C.; Nishiyama, T.; Louie, T. L.; Dashti, H. S.; Nakatochi, M.; Zee, P.; Daghlas, I.; Momozawa, Y.; Cai, J.; Ollila, H.; Redline, S.; Wakai, K.; Sofer, T.; Suzuki, S.; Lane, J.; Saxena, R.

10.1101/2022.02.16.480716 — genomics — Posted on 2022-02-19

1174 Assessing base-resolution DNA mechanics on the genome scale

Jiang, W.-j.; Hu, C.; Yi, X.; Xu, Q.; Lou, T.; Wang, H.; Zhou, J.; Zhu, H.; Li, Y.; Wen, Y.; Fan, R.; Shen, J.; Wong, C. C.; Zheng, X.; Wu, H.-J.

10.1101/2022.02.16.480786 — genomics — Posted on 2022-02-19

1175 Measuring drift by mean deviation: unequal breeding sex ratio revisited

Qin, B.

10.1101/2022.02.15.480610 — evolutionary biology — Posted on 2022-02-19

1176 Prey Size Spectra and Predator:Prey ratios of 7 Species of New Zealand Salps

Fender, C. K.; Decima, M.; Gutierrez-Rodriguez, A.; Selph, K. E.; Yingling, N.; Stukel, M. R.

10.1101/2022.02.16.480784 — ecology — Posted on 2022-02-19

1177 Maximizing citizen scientists' contribution to automated species recognition

Koch, W.; Hogeweg, L.; Nilsen, E. B.; Finstad, A. G.

10.1101/2022.02.17.480847 — ecology — Posted on 2022-02-19

1178 Interaction Interface between 5-HT3A serotonin receptor and chaperone RIC-3

Do, H. Q.; Jansen, M.

10.1101/2022.02.17.480943 — neuroscience — Posted on 2022-02-19

1179 Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans

Setty, H.; Salzberg, Y.; Karimi, S.; Berent-Barzel, E.; Krieg, M.; Oren-Suissa, M.

10.1101/2022.02.18.481005 — neuroscience — Posted on 2022-02-19

1180 Hierarchical decoupling of electromagnetic and haemodynamic cortical networks

Shafiei, G.; Baillet, S.; Misic, B.

10.1101/2021.09.07.458941 — neuroscience — Posted on 2022-02-19

1181 Volume-transmitted GABA waves drive epileptiform rhythms in the hippocampal network

Magloire, V.; Savtchenko, L. P.; Sylantyev, S.; Jensen, T. P.; Cole, N.; Marvin, J. S.; Looger, L. L.; Kullmann, D. M.; Walker, M. C.; Pavlov, I.; Rusakov, D. A.

10.1101/2021.03.25.437016 — neuroscience — Posted on 2022-02-19

1182 Dissecting the Genetic Architecture of Carbon Partitioning in Sorghum using Multiscale Phenotypes

Boatwright, J. L.; Sapkota, S. K.; Myers, M.; Kumar, N.; Cox, A.; Kresovich, S.

10.1101/2022.02.16.480719 — plant biology — Posted on 2022-02-19

1183 Apiaceae FNS I originated from F3H through tandem gene duplication

Pucker, B.; Iorizzo, M.

10.1101/2022.02.16.480750 — plant biology — Posted on 2022-02-19

1184 The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

Klein, A. B.; Nicolaisen, T. S.; Johann, K.; Fritzen, A. M.; Mathiesen, C. V.; Gil, C.; Pilmark, N. S.; Karstoft, K.; Blond, M. B.; Quist, J. S.; Seeley, R. J.; Faerch, K.; Lund, J.; Kleinert, M.; Clemmensen, C.

10.1101/2022.02.16.480373 — physiology — Posted on 2022-02-19

1185 INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

Woolley, J. F.; Chen, K.; Saffi, G. T.; Genc, G. E.; Lee, D. K. C.; Dzneladze, I.; He, R.; Chow, J. T.-S.; Gabra, M. M.; Son, M. H.; Melo, C. M. P.; Newell, C. A.; He, A.; Schoof, E. M.; Xie, S. Z.; Mangialardi, E. M.; Kotlyar, M.; Rashid, A.; Gams, M. S.; Vacher, J.; Guidos, C. J.; Jurisica, I.; Dick, J. E.; Botelho, R. J.; Minden, M. D.; Salmena, L.

10.1101/2021.03.25.437029 — cancer biology — Posted on 2022-02-19

1186 Notch signaling in tumor vasculature programs cancer-associated fibroblasts to suppress anti-tumor immunity

Zhu, Y.; Xiang, M.; Brulois, K.; Lazarus, N.; Pan, J.; Butcher, E.

10.1101/2022.02.16.480755 — cancer biology — Posted on 2022-02-19

1187 Inhibition of Glycogen Metabolism Induces Reactive Oxygen Species-Dependent Apoptosis in Anaplastic Thyroid Cancer

Davidson, C. D.; Tomczak, J. A.; Amiel, E.; Carr, F. E.

10.1101/2022.02.16.480663 — cancer biology — Posted on 2022-02-19

1188 Comprehensive dissection of immune microenvironment in the progression of early gastric cancer at spatial and single-cell resolution

Du, T.; Gao, H.; Wu, H.; Li, J.; Li, P.; Gao, J.; Qi, Q.; Liu, X.; Du, L.; Wang, Y.; Wang, C.

10.1101/2022.02.16.480776 — cancer biology — Posted on 2022-02-19

1189 Acoustic detection and identification of individual rooks in field recordings using multi-task neural networks

Martin, K.; Adam, O.; Obin, N.; Dufour, V.

10.1101/2022.02.19.481011 — biophysics — Posted on 2022-02-19

1190 A Bayesian Hierarchical Model for Signal Extraction from Protein Microarrays

Berube, S.; Kobayashi, T.; Norris, D. E.; Ruczinski, I.; Moss, W. J.; Wesolowski, A.; Louis, T. A.

10.1101/2022.02.16.480698 — bioinformatics — Posted on 2022-02-19

1191 Dual-Drug Loaded Biomimetic Chitosan-Collagen Hybrid Nanocomposite Scaffolds for Ameliorating Potential Tissue Regeneration in Diabetic Wounds

Tallapaneni, V.; Pamu, D.; Mude, L.; Karri, V. V. S. R.

10.1101/2022.02.16.480700 — bioengineering — Posted on 2022-02-19

1192 Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases

Fruergaard, M. U.; Nielsen, C. J. F.; Rosada, C.; Iversen, L.; Andersen, J. L.; Nissen, P.

10.1101/2022.02.18.481032 — biochemistry — Posted on 2022-02-19

1193 Every single conidium in Aspergillus fumigatus caspofungin tolerant strains are intrinsically caspofungin tolerant

Valero, C.; Colabardini, A. C.; de Castro, P. A.; Amich, J.; Bromley, M. J.; Goldman, G. H.

10.1101/2022.02.17.480978 — microbiology — Posted on 2022-02-19

1194 Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients

Oja, A. E.; Morgana, F.; Hagen, R.; Ghandour, C. A.; Nolte, M. A.; Rooijakkers, S.; van Lier, R. A. W.; Bardoel, B. W.; Hombrink, P.

10.1101/2022.02.16.479923 — immunology — Posted on 2022-02-19

1195 Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory

Simonnet, C.; Sinha, M.; Goutierre, M.; Moutkine, I.; Daumas, S.; Poncer, J. C.

10.1101/2022.02.18.481031 — neuroscience — Posted on 2022-02-19

1196 D2 dopamine receptor expression, sensitivity to rewards, and reinforcement learning in a complex value-based decision-making task

Banuelos, C.; Creswell, K.; Walsh, C.; Manuck, S. B.; Gianaros, P. J.; Verstynen, T.

10.1101/2022.02.18.481052 — neuroscience — Posted on 2022-02-19

1197 Brain signatures for neuropsychological and everyday memory achieve high replicability and explanatory power in two data cohorts

Fletcher, E.; Farias, S.; DeCarli, C.; Gavett, B.; Widaman, K.; DeLeon, F.; Mungas, D.

10.1101/2022.02.16.480746 — neuroscience — Posted on 2022-02-19

1198 Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field

Himmelberg, M. M.; Winawer, J.; Carrasco, M.

10.1101/2021.10.04.463138 — neuroscience — Posted on 2022-02-19

1199 Endocytosis-mediated vitellogenin absorption and lipid metabolism in the hindgut-derived pseudoplacenta of the viviparous teleost Xenotoca eiseni

Iida, A.; Nomura, J.; Yoshida, J.; Suzuki, T.; Yokoi, H.; Hondo, E.

10.1101/2022.02.16.480647 — zoology — Posted on 2022-02-19

1200 Multi-omics approach reveals dysregulation of protein phosphorylation correlated with lipid metabolism in mouse fatty liver

Kim, S. Q.; Mohallem, R.; Franco, J.; Buhman, K. K.; Kim, K.-H.; Aryal, U. K.

10.1101/2022.02.16.480672 — systems biology — Posted on 2022-02-19

1201 Secondary sexual dimorphism traits under abiotic stress in dioecious species: The case of Amaranthus palmeri

Korres, N. E.; Norsworthy, J. K.; FitzSimons, T.; Roberts, T. L.; Oosterhuis, D. M.; Govindjee, G.

10.1101/2022.02.15.480572 — plant biology — Posted on 2022-02-19

1202 Periductal bile acid exposure causes cholangiocyte injury and fibrosis

Dotan, M.; Fried, S.; Har-Zahav, A.; Shamir, R.; Wells, R. G.; Waisbourd-Zinman, O.

10.1101/2022.02.16.480650 — physiology — Posted on 2022-02-19

1203 Hypoxia modulates cellular endocytic pathways and organelles with enhanced cell migration and 3D cell invasion

NAVEENA, H. A.; Bhatia, D. D.

10.1101/2022.02.16.480665 — cancer biology — Posted on 2022-02-19

1204 Transglutaminase 2 associated with PI3K and PTEN in a putative membrane-bound signalosome platform blunts cell death

Jambrovics, K.; Boto, P.; Kolostyak, Z.; Zsolt, S.; Pap, A.; Szatmari, I.; Czimmerer, Z.; Uray, I. P.; Fesus, L.; Balajthy, Z.

10.1101/2022.02.16.480667 — cancer biology — Posted on 2022-02-19

1205 Salt Induced Transitions in the Conformational Ensembles of Intrinsically Disordered Proteins

Maity, H.; Baidya, L.; Reddy, G.

10.1101/2022.02.16.480648 — biophysics — Posted on 2022-02-19

1206 PycoMeth: A toolbox for differential methylation testing from Nanopore methylation calls

Snajder, R. H.; Stegle, O.; Bonder, M. J.

10.1101/2022.02.16.480699 — bioinformatics — Posted on 2022-02-19

1207 Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction

Tanikawa, S.; Ebisu, Y.; Sedlacik, T.; Semba, S.; Nonoyama, T.; Hirota, A.; Takahashi, T.; Yamaguchi, K.; Imajo, M.; Kato, H.; Nishimura, T.; Tanei, Z.-i.; Masumi, T.; Nemoto, T.; Gong, J. P.; Tanaka, S.

10.1101/2022.02.16.480448 — bioengineering — Posted on 2022-02-19

1208 Hamiltonian Monte Carlo with strict convergence criteria reduces run-to-run variability in forensic DNA mixture deconvolution

Susik, M.; Schoenborn, H.; Sbalzarini, I. F.

10.1101/2022.02.15.480571 — genetics — Posted on 2022-02-19

1209 Phenotypic Characterization of indigenous goat population in Southern, Ethiopia

Muluneh, T.; Tadesse, W.

10.1101/2022.02.16.480639 — genetics — Posted on 2022-02-19

1210 Transcriptional background effects on a tumor driver gene in a transgenic medaka melanoma model

Abdulsahib, S.; Boswell, W.; Boswell, M.; Savage, M.; Schartl, M.; Lu, Y.

10.1101/2022.02.16.480743 — genetics — Posted on 2022-02-19

1211 Managing beach access and vehicle impacts following reconfiguration of the landscape by a natural hazard event

Orchard, S.; Fischman, H. S.; Schiel, D. R.

10.1101/2022.02.15.480598 — ecology — Posted on 2022-02-19

1212 MoveApps - a serverless no-code analysis platform for animal tracking data

Koelzsch, A.; Davidson, S. C.; Gauggel, D.; Hahn, C.; Hirt, J.; Kays, R.; Lang, I.; Lohr, A. K.; Russell, B.; Scharf, A. K.; Schneider, G.; Vinciguerra, C.; Wikelski, M.; Safi, K.

10.1101/2022.02.15.480513 — ecology — Posted on 2022-02-19

1213 Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in BALB/c mice.

Dzul-Huchim, V. M.; Ramirez-Sierra, M. J.; Martinez-Vega, P. P.; Rosado-Vallado, M. E.; Arana-Argaez, V. E.; Ortega-Lopez, J.; Gusovsky, F.; Dumonteil, E.; Cruz-Chan, J. V.; Hotez, P.; Bottazzi, M. E.; Villanueva Lizama, L. E.

10.1101/2022.02.16.480638 — immunology — Posted on 2022-02-19

1214 Demise of Marimermithida refines primary routes of transition to parasitism in roundworms

Tchesunov, A. V.; Nikolaeva, O. V.; Rusin, L. Y.; Sanamyan, N. P.; Panina, E. G.; Miljutin, D. M.; Gorelysheva, D. I.; Pegova, A. N.; Khromova, M. R.; Mardashova, M. V.; Mikhailov, K. V.; Yushin, V. V.; Petrov, N. B.; Lyubetsky, V. A.; Nikitin, M. A.; Aleoshin, V. V.

10.1101/2022.02.15.480519 — zoology — Posted on 2022-02-19

1215 Mechanistic model for human brain metabolism and the neurovascular coupling.

Sundqvist, N.; Sten, S.; Engström, M.; Cedersund, G.

10.1101/2022.02.15.480629 — systems biology — Posted on 2022-02-19

1216 Hematological and gene co-expression network analyses of high-risk beef cattle defines immunological mechanisms and biological complexes involved in bovine respiratory disease and weight gain

Scott, M. A.; Woolums, A.; Swiderski, C.; Finley, A.; Perkins, A.; Nanduri, B.; Karisch, B.

10.1101/2022.02.16.480640 — systems biology — Posted on 2022-02-19

1217 Creating De Novo Overlapped Genes

Logel, D. Y.; Jaschke, P. R.

10.1101/2022.02.15.480625 — synthetic biology — Posted on 2022-02-19

1218 Niche differentiation following whole-genome duplication? The importance of considering the intricate evolutionary history of polyploids when assessing climatic niche evolution

Padilla-Garcia, N.; Sramkova, G.; Zaveska, E.; Slenker, M.; Clo, J.; Zeisek, V.; Lucanova, M.; Rurane, I.; Kolar, F.; Marhold, K.

10.1101/2022.02.16.480351 — plant biology — Posted on 2022-02-19

1219 AAV2/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modification

Gautier, B.; Meneux, L.; Feret, N.; Audrain, C.; Hudecek, L.; Kuony, A.; Bourdon, A.; Le Guiner, C.; Blouin, V.; Delettre, C.; Michon, F.

10.1101/2022.02.16.480632 — physiology — Posted on 2022-02-19

1220 RAID: Regression Analysis based Inductive DNA microarray for Precise Read-Across

Amano, Y.; Yamane, M.; Honda, H.

10.1101/2022.02.15.480621 — pharmacology and toxicology — Posted on 2022-02-19

1221 How to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells?A case study in patient-derived glioblastoma organoids

Gaska, W.; Lokh, C.; Verduin, M.; Hubert, C. G.; Vooijs, M.; Cavill, R.; Stankova, K.

10.1101/2022.01.26.477755 — cancer biology — Posted on 2022-02-19

1222 scDVF: Data-driven Single-cell Transcriptomic Deep Velocity Field Learning with Neural Ordinary Differential Equations

Chen, Z.; King, W. C.; Gerstein, M.; Zhang, J.

10.1101/2022.02.15.480564 — bioinformatics — Posted on 2022-02-19

1223 TAMC: A deep-learning approach to predict motif-centric transcriptional factor binding activity based on ATAC-seq profile

Yang, T.; Henao, R.

10.1101/2022.02.15.480482 — bioinformatics — Posted on 2022-02-19

1224 Uniformity of spheroid-on-chip by surface treatment of PDMS microfluidic platforms

Azizipour, N.; Avazpour, R.; Sawan, M.; Rosenzweig, D.; Ajji, A.

10.1101/2022.02.15.480543 — bioengineering — Posted on 2022-02-19

1225 Squamation and scale morphology at the root of jawed vertebrates

Wang, Y.; Zhu, M.

10.1101/2022.02.15.480555 — evolutionary biology — Posted on 2022-02-19

1226 Nitric oxide signaling controls collective contractions in a colonial choanoflagellate

Reyes-Rivera, J.; Wu, Y.; Guthrie, B. G. H.; Marletta, M. A.; King, N.; Brunet, T.

10.1101/2022.02.14.480389 — evolutionary biology — Posted on 2022-02-19

1227 Are microbes growing on flowers evil? Effects of old flower microbes on fruit set in a wild ginger with one-day flowers, Alpinia japonica (Zingiberaceae)

Sakai, S.; Ushio, M.; Elvira, N. J.

10.1101/2021.06.28.450259 — ecology — Posted on 2022-02-19

1228 Predicting TCR-peptide recognition based on residue-level pairwise statistical potential

Karnaukhov, V. K.; Shcherbinin, D. S.; Chugunov, A. O.; Chudakov, D. M.; Efremov, R. G.; Zvyagin, I. V.; Shugay, M.

10.1101/2022.02.15.480516 — immunology — Posted on 2022-02-19

1229 Seeing light from a different angle: the effects of diffuse light on the function, structure, and growth of tomato plants

Ellertson, K.; Goldsmith, G.; Berry, C.

10.1101/2022.02.15.480600 — plant biology — Posted on 2022-02-19

1230 CoDNaS-Q: a database of conformational diversity of the native state of proteins with quaternary structure

Escobedo, N.; Tunque Cahui, R. R.; Caruso, G.; Garcia Rios, E.; Hirsh, L.; Monzon, A. M.; Parisi, G.; Palopoli, N.

10.1101/2022.02.15.480082 — bioinformatics — Posted on 2022-02-19

1231 StrainPanDA: linked reconstruction of strain composition and gene content profiles via pangenome-based decomposition of metagenomic data

Hu, H.; Tan, Y.; Li, C.; Chen, J.; Kou, Y.; Xu, Z.; Liu, Y.-Y.; Tan, Y.; Dai, L.

10.1101/2022.02.15.480535 — bioinformatics — Posted on 2022-02-19

1232 Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy

Manna, K.; Dharanipragada, P.; Alkam, D. H.; Avaritt, N. L.; Washam, C. L.; Robeson, M. S.; Edmondson, R. D.; Mackintosh, S. G.; Yang, Z.; Wang, Y.; Lomeli, S.; Moriceau, G.; Byrum, S.; Lo, R.; Tackett, A. J.

10.1101/2022.02.15.480454 — bioinformatics — Posted on 2022-02-19

1233 An integrated strain-level analytic pipeline utilizing longitudinal metagenomic data

Zhou, B.; Wang, C.; Putzel, G.; Hu, J.; Liu, M.; Wu, F.; Chen, Y.; Pironti, A.; Li, H.

10.1101/2022.02.15.480548 — bioinformatics — Posted on 2022-02-19

1234 Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent minimal MET receptor agonist.

de Nola, G.; Leclerc, B.; Mougel, A.; Dezitter-Taront, S.; Simonneau, C.; Forneris, F.; Adriaenssens, E.; Drobecq, H.; Melnyk, O.; Gherardi, E.; de Jonge, H.; Vicogne, J.

10.1101/2020.07.20.212654 — bioengineering — Posted on 2022-02-19

1235 Emergent regulation of ant foraging frequency through a computationally inexpensive forager movement rule

Baltiansky, L.; Frankel, G.; Feinerman, O.

10.1101/2022.02.15.480539 — animal behavior and cognition — Posted on 2022-02-19

1236 Host-associated phages disperse across the extraterrestrial analogue Antarctica

Rahlff, J.; Bornemann, T. L. V.; Lopatina, A.; Severinov, K.; Probst, A. J.

10.1101/2021.11.09.467789 — microbiology — Posted on 2022-02-19

1237 Spatiotemporally Mapping Thermodynamics of Lysosomes and Mitochondria using Cascade Organelle-Targeting Upconversion Nanoparticles

Su, Q. P.; Di, X.; Wang, D.; Liu, Y.; maddahfar, m.; Zhou, J.; Jin, D.

10.1101/2022.02.16.480800 — biophysics — Posted on 2022-02-19

1238 Dependence of diffusion in Escherichia coli cytoplasm on protein size, environmental conditions and cell growth

Sourjik, V.; Bellotto, N.; Agudo-Canalejo, J.; Colin, R.; Golestanian, R.; Malengo, G.

10.1101/2022.02.17.480843 — biophysics — Posted on 2022-02-19

1239 Rapamycin treatment during development extends lifespan and healthspan

Shindyapina, A.; Cho, Y.; Kaya, A.; Tyshkovskiy, A.; Castro, J. P.; Gordevicius, J.; Poganik, J. R.; Horvath, S.; Peshkin, L.; Gladyshev, V. N.

10.1101/2022.02.18.481092 — developmental biology — Posted on 2022-02-19

1240 Lifespan can be extended during a specific time window early in life

Tiberi, L.

10.1101/2022.02.18.480980 — cell biology — Posted on 2022-02-19

1241 Partial illustration of human sperm DNA via microscopy and quantitative analysis of nucleotides

Barzideh, J.

10.1101/2022.02.18.481020 — cell biology — Posted on 2022-02-19

1242 The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

Saha, I.; Yuste-Checa, P.; da Silva Padilha, M.; Guo, Q.; Körner, R.; Holthusen, H.; Trinkaus, V. A.; Dudanova, I.; Fernandez-Busnadiego, R.; Baumeister, W.; Sanders, D. W.; Gautam, S.; Diamond, M. I.; Hartl, F.-U.; Hipp, M. S.

10.1101/2022.02.18.481043 — cell biology — Posted on 2022-02-19

1243 Genomewide m6A mapping uncovers dynamic changes in the m6A epitranscriptome of cisplatin-treated apoptotic HeLa cells

Akcaoz, A.; Tuncel, O.; Gelmez, A. B.; Saglam, B.; Vatansever, I. E.; Akgul, B.

10.1101/2022.02.18.481057 — cell biology — Posted on 2022-02-19

1244 The influence of leaf anatomical traits on photosynthetic in coffee leaves in Yunnan of China

Xiao, Z.; Ma, G.; Bai, X.; Li, J.; Su, L.; Zhao, M.; Ma, H.; Zhou, H.

10.1101/2022.02.18.481015 — biophysics — Posted on 2022-02-19

1245 Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces

Francis, E. A.; Xiao, H.; Teng, L. H.; Heinrich, V.

10.1101/2022.02.18.481104 — biophysics — Posted on 2022-02-19

1246 Regulatory mechanisms of the dynein-2 motility by post-translational modification revealed by molecular dynamic simulation

Kubo, S.; Bui, K. H.

10.1101/2022.02.17.480877 — biophysics — Posted on 2022-02-19

1247 Substrate stiffness impacts early biofilm formation via a modulation of twitching motility

Gomez Ho, S.; Bureau, L.; John, K.; Debarre, D.; Lecuyer, S.

10.1101/2022.02.18.480999 — biophysics — Posted on 2022-02-19

1248 Spatially resolved epigenomic profiling of single cells in complex tissues

Lu, T.; Ang, C. E.; Zhuang, X.

10.1101/2022.02.17.480825 — genomics — Posted on 2022-02-19

1249 Bespoke data augmentation and network construction enable image classification on small microscopy datasets

Groves, I.; Holmshaw, J.; Furley, D.; Evans, B. D.; Placzek, M.; Fletcher, A. G.

10.1101/2022.02.18.480991 — developmental biology — Posted on 2022-02-19

1250 Mural norrin/β-catenin signaling regulates Lama2 expression to promote neurovascular unit assembly

Biswas, S.; Shahriar, S.; Giangreco, N. P.; Arvanitis, P.; Winkler, M.; Tatonetti, N. P.; Brunken, W. J.; Cutforth, T.; Agalliu, D.

10.1101/2022.02.18.481046 — developmental biology — Posted on 2022-02-19

1251 GPX4-associated Sedaghatian Type Spondylometaphyseal Dysplasia: A Protein Interactome Perspective

Karunakaran, K. B.; Balakrishnan, N.; Ganapathiraju, M.

10.1101/2022.02.17.479371 — developmental biology — Posted on 2022-02-19

1252 Borrowing ecological theory to infer interactions between sensitive and resistant breast cancer cell populations

Susswein, Z.; Sengupta, S.; Clarke, R.; Bansal, S.

10.1101/2022.02.18.481041 — cell biology — Posted on 2022-02-19

1253 MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 gene

Zheng, Z.; Wu, L.; Li, Z.; Tang, R.; Li, H.; Huang, Y.; Ye, Z.; Xiao, D.; Wu, G.; Jaspers, R. T.; Pathak, J. L.

10.1101/2022.02.18.480982 — cell biology — Posted on 2022-02-19

1254 A Ferroptosis-mediated regulation of the biogenesis of the oxidative phosphorylation system

Murari, A.; Rhooms, S.-k.; Hossain, K.; Liu, T.; Li, H.; Goparaju, N. S.; Osei, C.; Owusu-Ansah, E.

10.1101/2022.02.17.480976 — cell biology — Posted on 2022-02-19

1255 Prolonged β-Adrenergic Stimulation Disperses Ryanodine Receptor Clusters in Cardiomyocytes: Implications for Heart Failure

Shen, X.; van den Brink, J.; Bergan-Dahl, A.; Kolstad, T. R.; Norden, E. S.; Hou, Y.; Laasmaa, M.; Quick, A. P.; Espe, E. K. S.; Sjaastad, I.; Wehrens, X.; Edwards, A.; Soeller, C.; Louch, W. E.

10.1101/2022.02.18.481024 — cell biology — Posted on 2022-02-19

1256 Asymmetric requirement for α-tubulin over β-tubulin

Wethekam, L. C.; Moore, J. K.

10.1101/2022.02.17.480930 — cell biology — Posted on 2022-02-19

1257 Dyslexia linked to profound impairment in the magnocellular medial geniculate nucleus

Meng, Q.; Schneider, K. A.

10.1101/2022.02.18.481044 — neuroscience — Posted on 2022-02-18

1258 Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin

Rasicci, D. V.; Tiwari, P.; Desetty, R.; Sadler, F. R.; Sivaramakrishnan, S.; Craig, R.; Yengo, C. M.

10.1101/2022.02.18.480995 — biophysics — Posted on 2022-02-19

1259 Protein compactness and interaction valency define the architecture of a biomolecular condensate across scales

Polyansky, A. A.; Gallego, L. D.; Efremov, R. G.; Koehler, A.; Zagrovic, B.

10.1101/2022.02.18.481017 — biophysics — Posted on 2022-02-19

1260 Tracer particles sense local stresses in an evolving multicellular spheroid without affecting the anomalous dynamics of the cancer cells

Samanta, H.; Sinha, S.; Thirumalai, D.

10.1101/2022.02.18.481003 — biophysics — Posted on 2022-02-19

1261 NUCLEAR RETENTION OF LEPTIN/UPD2 REGULATES ORGANISMAL RESILIENCE TO NUTRIENT EXTREMES

Poling, M. E.; Sullivan, C. E.; Madan, A.; Kelly, K. P.; Brent, A. E.; Dubrulle, J.; Raghavan, P.; Rajan, A.

10.1101/2021.01.29.428913 — molecular biology — Posted on 2022-02-18

1262 Molecular characteristics and laminar distribution of prefrontal neurons projecting to the mesolimbic system

Babiczky, A.; Matyas, F.

10.1101/2022.02.17.480862 — neuroscience — Posted on 2022-02-18

1263 Self-organization of songbird neural sequences during social isolation

Mackevicius, E. L.; Gu, S.; Denisenko, N.; Fee, M.

10.1101/2022.02.18.480996 — neuroscience — Posted on 2022-02-18

1264 Reduced variability of bursting activity during working memory

Lundqvist, M.; Rose, J.; Warden, M. R.; Buschman, T. J.; Herman, P. A.; Miller, E. K.

10.1101/2022.02.18.481088 — neuroscience — Posted on 2022-02-18

1265 Automated verification, assembly, and extension of GBM stem cell network model with knowledge from literature and data

Holtzapple, E.; Cochran, B.; Miskov-Zivanov, N.

10.1101/2021.07.04.451062 — systems biology — Posted on 2022-02-18

1266 Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy

Holzer, A.-K.; Suciu, I.; Karreman, C.; Goj, T.; Leist, M.

10.1101/2022.02.17.479688 — pharmacology and toxicology — Posted on 2022-02-18

1267 Reliable and efficient parameter estimation using approximate continuum limit descriptions of stochastic models

Simpson, M. J.; Baker, R. E.; Buenzli, P. R.; Nicholson, R.; Maclaren, O. J.

10.1101/2022.02.02.478913 — biophysics — Posted on 2022-02-18

1268 DeepImageTranslator V2: analysis of multimodal medical images using semantic segmentation maps generated through deep learning

Ye, E. Z.; Ye, E. H.; Bouthillier, M.; Ye, R. Z.

10.1101/2021.10.12.464160 — bioinformatics — Posted on 2022-02-18

1269 Synthetic lethality between toxic amino acids, retrograde target genes and chaperones in Saccharomyces cerevisiae

Druseikis, M. E.; Covo, S.

10.1101/2022.02.18.481112 — genetics — Posted on 2022-02-18

1270 Density dependent environments can select for extremes of body size

Coulson, T.; Felmy, A.; Potter, T.; Passoni, G.; Montgomery, R. A.; Gaillard, J.-M.; Hudson, P. J.; Travis, J.; Bassar, R. D.; Tuljapurkar, S. D.; Marshall, D.; Clegg, S. M.

10.1101/2022.02.17.480952 — evolutionary biology — Posted on 2022-02-18

1271 Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in mice

O'Keefe, R. N.; Carli, A.; Baloyan, D.; Sterle, S.; Eissmann, M. F.; Poh, A. R.; Seillet, C.; Locksley, R. M.; Ernst, M. M.; Buchert, M.

10.1101/2022.02.16.480779 — cancer biology — Posted on 2022-02-18

1272 C. difficile is overdiagnosed in adults and a commensal in infants

Ferretti, P.; Wirbel, J.; Maistrenko, O. M.; Van Rossum, T.; Alves, R.; Fullam, A.; Akanni, W.; Schudoma, C.; Schwarz, A.; Thielemann, R.; Thomas, L.; Kuhn, M.; Zeller, G.; Schmidt, T. S.; Bork, P.

10.1101/2022.02.16.480740 — microbiology — Posted on 2022-02-18

1273 Using Mathematical Modeling to Distinguish Intrinsic and Acquired Targeted Therapeutic Resistance in Head and Neck Cancer

Cardenas, S. D.; Reznik, C. J.; Ranaweera, R.; Song, F.; Chung, C. H.; Fertig, E. J.; Gevertz, J. L.

10.1101/2022.02.18.481078 — cancer biology — Posted on 2022-02-18

1274 The Effect of Lipid Composition on the Dynamics of Tau Fibrils

Dutta Chowdhury, U.; Paul, A.; Bhargava, B. L.

10.1101/2022.02.16.480652 — biophysics — Posted on 2022-02-18

1275 ABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA and DDA mass spectrometry methods

Jones, H. B. L.; Heilig, R.; Davis, S.; Fisher, R.; Kessler, B. M.; Pinto-Fernandez, A.

10.1101/2022.02.18.480987 — biochemistry — Posted on 2022-02-18

1276 Multi-eGO: an in-silico lens to look into protein aggregation kinetics at atomic resolution

Scalone, E.; Broggini, L.; Visentin, C.; Erba, D.; Bacic Toplek, F.; Peqini, K.; Pellegrino, S.; Ricagno, S.; Paissoni, C.; Camilloni, C.

10.1101/2022.02.18.481033 — biochemistry — Posted on 2022-02-18

1277 Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1

Sutinen, A.; Nguyen, G. T. T.; Raasakka, A.; Muruganandam, G.; Loris, R.; Ylikallio, E.; Tyynismaa, H.; Bartesaghi, L.; Ruskamo, S.; Kursula, P.

10.1101/2022.02.18.481076 — biochemistry — Posted on 2022-02-18

1278 Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales

Morgan, A. P.; Hughes, J. J.; Didion, J. P.; Jolley, W. J.; Campbell, K. J.; Threadgill, D. W.; Bonhomme, F.; Searle, J. B.; Pardo Manuel de Villena, F.

10.1101/2022.02.17.478179 — genetics — Posted on 2022-02-18

1279 Species-Specific Formation of Paraspeckles in Intestinal Epithelium Revealed by Characterization of NEAT1 in Naked Mole-rat

Yamada, A.; Toya, H.; Tanahashi, M.; Kurihara, M.; Mito, M.; Iwasaki, S.; Kurosaka, S.; Takumi, T.; Fox, A.; Kawamura, Y.; Miura, K.; Nakagawa, S.

10.1101/2022.02.17.480918 — molecular biology — Posted on 2022-02-18

1280 Genome-wide analyses of histone modifications and chromatin accessibility reveal the distinct genomic compartments in the Irish potato famine pathogen Phytophthora infestans

Chen, H.; Shu, H.; Fang, Y.; Song, W.; Li, Z.; Fang, Y.; Wang, Y.; Dong, S.

10.1101/2022.02.18.480484 — microbiology — Posted on 2022-02-18

1281 Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

Bohrer, A. C.; Castro, E.; Tocheny, C. E.; Assmann, M.; Schwarz, B.; Bohrnsen, E.; Makiya, M. A.; Legrand, F.; Hilligan, K. L.; Baker, P. J.; Torres-Juarez, F.; Hu, Z.; Ma, H.; Wang, L.; Niu, L.; Wen, Z.; Lee, S.; Kamenyeva, O.; Tuberculosis Imaging Program, ; Kauffman, K. D.; Donato, M.; Sher, A.; Barber, D. L.; Via, L. E.; Scriba, T.; Khatri, P.; Song, Y.; Wong, K.-W.; Bosio, C. M.; Klion, A. D.; Mayer-Barber, K. D.

10.1101/2022.02.18.480919 — immunology — Posted on 2022-02-18

1282 IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

Das Gupta, D.; Paul, C.; Samel, N.; Bieringer, M.; Staudenraus, D.; Marini, F.; Raifer, H.; Menke, L.; Hansal, L.; Camara, B.; Roth, E.; Daum, P.; Wanzel, M.; Mernberger, M.; Nist, A.; Bauer, U.-M.; Helmprobst, F.; Buchholz, M.; Roth, K.; Bastian, L.; Hartmann, A. M.; Baldus, C.; Ikuta, K.; Neubauer, A.; Burchert, A.; Jaeck, H.-M.; Klein, M.; Bopp, T.; Stiewe, T.; Pagenstecher, A.; Lohoff, M.

10.1101/2022.02.16.480573 — cancer biology — Posted on 2022-02-18

1283 Changing flows balance nutrient absorption and bacterial growth along the gut

Codutti, A.; Cremer, J.; Alim, K.

10.1101/2022.02.16.480685 — biophysics — Posted on 2022-02-18

1284 Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome

Evans, S. L.; Al-Hazeem, M.; Mann, D.; Smetacek, N.; Beavil, A.; Sun, Y.; Chen, T.; Dykes, G.; Liu, L.-N.; Bergeron, J.

10.1101/2022.02.18.481072 — biophysics — Posted on 2022-02-18

1285 A protein semisynthesis-based strategy to probe the impact of site-specific serine ADP-ribosylation on linker histone function

Tashiro, K.; Mohapatra, J.; Brautigam, C. A.; Liszczak, G.

10.1101/2022.02.17.480967 — biochemistry — Posted on 2022-02-18

1286 Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

Frosi, Y.; Ng, S.; Lin, Y.-C.; Jiang, S.; Ramlan, S. R.; Lama, D.; Verma, C. S.; Asial, I.; Brown, C. J.

10.1101/2022.02.17.480295 — biochemistry — Posted on 2022-02-18

1287 DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons

Mazza, M. C.; Shuck, S.; Lin, J.; Moxley, M. A.; Termini, J.; Cookson, M. R.; Wilson, M. A.

10.1101/2022.02.18.481064 — biochemistry — Posted on 2022-02-18

1288 The accuracy of absolute differential abundance analysis from relative count data

Roche, K. E.; Mukherjee, S.

10.1101/2021.12.06.471397 — genomics — Posted on 2022-02-18

1289 Benchmarking Polygenic Risk Score Model Assumptions: towards more accurate risk assessment

Kulm, S.; Mezey, J.; Elemento, O.

10.1101/2022.02.18.480983 — genomics — Posted on 2022-02-18

1290 Contribution of spontaneous mutations to quantitative and molecular variation at the highly repetitive rDNA locus in yeast

Sharp, N. P.; Smith, D. R.; Driscoll, G.; Sun, K.; Vickerman, C. M.; Martin, S. C. T.

10.1101/2022.02.17.480951 — genetics — Posted on 2022-02-18

1291 m6a governs length-dependent enrichment of mRNAs in stress granules

Ries, R. J.; Pickering, B. F.; Poh, H. X.; Namkoong, S.; Jaffrey, S. R.

10.1101/2022.02.18.480977 — molecular biology — Posted on 2022-02-18

1292 The Chlamydia protein CpoS modulates the inclusion microenvironment and restricts the interferon response by acting on Rab35

Meier, K.; Jachmann, L. H.; Pérez, L.; Kepp, O.; Valdivia, R. H.; Kroemer, G.; Sixt, B. S.

10.1101/2022.02.18.481055 — microbiology — Posted on 2022-02-18

1293 The effect of cytoskeleton inhibitors on coccolith morphology in Coccolithus braarudii and Scyphosphaera apsteinii

Langer, G.; Probert, I.; Taylor, A. R.; Harper, G.; Brownlee, C.; Wheeler, G. L.

10.1101/2022.02.18.480830 — microbiology — Posted on 2022-02-18

1294 Aquatic long-term persistence of Francisella tularensis ssp. holarctica is driven by water temperature and transition to a viable but non-culturable state

Camille, B. D.; Peyroux, J.; Ponderand, L.; Bouillot, S.; Girard, T.; Faudry, E.; Maurin, M.; Caspar, Y.

10.1101/2022.02.18.480867 — microbiology — Posted on 2022-02-18

1295 Hinokitiol alters Gene Expression in Aspergillus fumigatus, protects against fungal keratitis by Reducing Fungal Load, LOX-1, Proinflammatory cytokines and Neutrophil Infiltration

Ma, S.; Lin, H.; Peng, X.; Li, C.; Wang, Q.; Xu, Q.; He, M.; Shao, D.; Liu, X.; Zhao, G.; Lin, J.

10.1101/2022.02.18.480984 — microbiology — Posted on 2022-02-18

1296 Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases

Elsworth, B.; Keroack, C. D.; Rezvani, Y.; Tennessen, J. A.; Sack, S. A.; Paul, A.; Moreira, C. K.; Gubbels, M.-J.; Zarringhalam, K.; Duraisingh, M. T.

10.1101/2022.02.17.480550 — microbiology — Posted on 2022-02-18

1297 Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during KSHV lytic replication.

Rodriguez, W.; Mehrmann, T.; Muller, M.

10.1101/2022.02.18.480778 — microbiology — Posted on 2022-02-18

1298 Cross-kingdom metagenomic profiling of Lake Hillier reveals pigment-rich polyextremophiles and wide-ranging metabolic adaptations

Sierra, M.; Ryon, K.; Tierney, B.; Foox, J.; Bhattacharya, C.; Afshin, E.; Butler, D.; Green, S.; Thomas, K.; Ramsdell, J.; Bivens, N.; McGrath, K.; Mason, C.; Tighe, S. W.

10.1101/2022.02.17.480683 — microbiology — Posted on 2022-02-18

1299 Transcriptome analysis of diverse Plasmodium falciparum clinical isolates identifies genes correlating with highly variable expression of merozoite surface protein MSPDBL2

Hocking, S. E.; Stewart, L. B.; Tarr, S. J.; Freville, A.; Tetteh, K.; Ahouidi, A. D.; Amambua-Ngwa, A.; Diakite, M.; Awandare, G. A.; Conway, D.

10.1101/2022.02.18.481051 — microbiology — Posted on 2022-02-18

1300 Leishmania amazonensis infection induces PD-L1 expression on dendritic cells in an mTor-dependent manner and impairs Th1 responses in vitro and in vivo

de Matos Guedes, H. L.; da Fonseca-Martins, A. M.; Liang, Y.; Carlsen, E. D.; Henard, C. A.; Pinchuk, I. V.; Soong, L.

10.1101/2022.02.15.480617 — immunology — Posted on 2022-02-18

1301 Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

Chen, C.; Martinez, D. R.; Marti, M. M.; Schaefer, A.; Cheng, M. H.; Mannar, D.; Zhu, X.; Berezuk, A. M.; Banerjee, A.; Sobolewski, M. D.; Kim, A.; Treat, B. R.; Da Silva Castanha, P. M.; Enick, N.; McCormick, K. D.; Liu, X.; Adams, C.; Hines, M. G.; Sun, Z.; Chen, W.; Jacobs, J. L.; Barratt-Boyes, S. M.; Mellors, J. W.; Baric, R. S.; Bahar, I.; Dimitrov, D. S.; Subramaniam, S.; Saville, J. W.; Li, W.

10.1101/2022.02.18.481058 — immunology — Posted on 2022-02-18

1302 Spectrum of BDNF expression changes and reactive glial phenotypes across brain regions precede neuronal loss and are associated with therapeutic effects of BDNF in SCA1

Rosa, J.-G.; Hamel, K.; Sheeler, C.; Borgenheimer, E.; Gilliat, S.; Soles, A.; Ghannoum, F.; Sbrocco, K.; Forster, C.; Rainwater, O.; Orr, H.; Cvetanovic, M.

10.1101/2021.09.13.460129 — neuroscience — Posted on 2022-02-18

1303 Inactivity and Ca2+ signaling regulate synaptic compensation in motoneurons following hibernation in American bullfrogs

Zubov, T.; do Amaral-Silva, L.; Santin, J. M.

10.1101/2022.01.26.477843 — neuroscience — Posted on 2022-02-18

1304 Recurrent Connections in the Primate Ventral Visual Stream Mediate a Tradeoff Between Task Performance and Network Size During Core Object Recognition

Nayebi, A.; Sagastuy-Brena, J.; Bear, D. M.; Kar, K.; Kubilius, J.; Ganguli, S.; Sussillo, D.; DiCarlo, J. J.; Yamins, D. L. K.

10.1101/2021.02.17.431717 — neuroscience — Posted on 2022-02-18

Hardwick, R. M.; Forrence, A. D.; Costello, M. G.; Zachowski, K.; Haith, A. M.

10.1101/2021.06.12.448183 — neuroscience — Posted on 2022-02-18

1306 Designing single-cell experiments to harvest fluctuation information while rejecting measurement noise

Vo, H. D.; Munsky, B. E.

10.1101/2021.05.11.443611 — systems biology — Posted on 2022-02-18

1307 Furin-cleavage site is present in an antiparallel β-strand in SARS-CoV2 Spike protein

Bashir, A.

10.1101/2022.02.18.481028 — bioinformatics — Posted on 2022-02-18

1308 Mosaic receptor-binding domain nanoparticles induce protective immunity against SARS-CoV-2 challenges

Lee, D. B.; Kim, H.; Jeong, J. H.; Jang, E. s.; Chang, Y. Y.; Roh, S.; Jeon, H.; Kim, E. J.; Han, S. Y.; Maeng, J. Y.; Magez, S.; Radwanska, M.; Mun, J. Y.; Jun, H. S.; Lee, G.; Song, M.-S.; Lee, H.-R.; Chung, M. S.; Baek, Y. H.; Kim, K. H.

10.1101/2022.02.18.480994 — bioengineering — Posted on 2022-02-18

1309 Interfacial tension driven open droplet microfluidics

Khor, J. W.; Lee, U. N.; Berthier, J.; Berthier, E.; Theberge, A. B.

10.1101/2021.07.29.454194 — bioengineering — Posted on 2022-02-18

1310 Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine

Kimura, S.; Srisuknimit, V.; McCarty, K.; Dedon, P. C.; Kranzusch, P. J.; Waldor, M. K.

10.1101/2022.02.17.480965 — biochemistry — Posted on 2022-02-18

1311 Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2

Alderson, T. R.; Pritisanac, I.; Moses, A. M.; Forman-Kay, J. D.

10.1101/2022.02.18.481080 — biochemistry — Posted on 2022-02-18

1312 The high-throughput perturbation of long non-coding RNA reveals functional features in stem cells and across cell-types

Yip, C. W.; Hon, C.-C.; Yasuzawa, K.; Mundackal Sivaraman, D.; Ramilowski, J. A.; Shibayama, Y.; Agrawal, S.; Prabhu, A. V.; Parr, C.; Severin, J.; Lan, Y. J.; Dostie, J.; Nishiyori-Sueki, H.; Tagami, M.; Ito, M.; Lopez-Redondo, F.; Kouno, T.; Chang, J.-C.; Luginbuhl, J.; Kato, M.; Murata, M.; Yip, W. H.; Shu, X.; Abugessaisa, I.; Hasegawa, A.; Suzuki, H.; Yagi, K.; Kasukawa, T.; de Hoon, M. J. L.; Carninci, P.; Shin, J. W.

10.1101/2022.02.16.480297 — genomics — Posted on 2022-02-18

1313 The parasitic nematode Strongyloides ratti exists as populations of long-lived asexual lineages.

Cole, R.; Holroyd, N.; Tracey, A.; Berriman, M. M.; Viney, M.

10.1101/2021.05.26.445462 — genetics — Posted on 2022-02-18

1314 Genomic Characterization of Sars-Cov-2 from Islamabad Pakistan by Rapid Nanopore Sequencing

Badar, N.; Ikram, A.; Salman, M.; Umair, M.; Rehman, Z.; Ahad, A.; Mirza, H. a.; Alam, M.; Mehmood, N.; aamir, U. B.

10.1101/2022.02.17.480826 — molecular biology — Posted on 2022-02-18

1315 Molecular snapshots of drug release from tubulin over eleven orders of magnitude in time

Wranik, M.; Weinert, T.; Slavov, C.; Masini, T.; Furrer, A.; Gaillard, N.; Gioia, D.; Ferrarotti, M.; James, D.; Glover, H.; Carrillo, M.; Kekilli, D.; Stipp, R.; Skopintsev, P.; Bruenle, S.; Muehlethaler, T.; Beale, J.; Gashi, D.; Nass, K.; Ozerov, D.; Johnson, P. J. M.; Cirelli, C.; Bacellar, C.; Braun, M.; Wang, M.; Dworkowski, F.; Milne, C.; Cavalli, A.; Wachtveitl, J.; Steinmetz, M.; Standfuss, J.

10.1101/2022.02.17.480857 — molecular biology — Posted on 2022-02-18

1316 Metagenomic analysis reveals the abundance and diversity of opportunistic fungal pathogens in the nasopharyngeal tract of COVID-19 patients

Hoque, M. N.; Rahman, M. S.; Sarkar, M. M. H.; Habib, M. A.; Hossain, M. A.; Khan, M. S.; Islam, T.

10.1101/2022.02.17.480819 — microbiology — Posted on 2022-02-18

1317 SARS-CoV-2 has not emerged in roe, red or fallow deer in Germany or Austria during the COVID 19 pandemic

Moreira-Soto, A.; Walzer, C.; Czirjak, G. A.; Richter, M.; Marino, S. F.; Posautz, A.; Rodo de Yebra, P.; McEwen, G. K.; Drexler, J. F.; Greenwood, A. D.

10.1101/2022.02.18.480872 — microbiology — Posted on 2022-02-18

1318 Preparing for the next COVID: Deep Reinforcement Learning trained Artificial Intelligence discovery of multi-modal immunomodulatory control of systemic inflammation in the absence of effective anti-microbials

Larie, D.; An, G.; Cockrell, C.

10.1101/2022.02.17.480940 — immunology — Posted on 2022-02-18

1319 Relative positioning of B and T cell epitopes drives immunodominance.

Biavasco, R.; De Giovanni, M.

10.1101/2022.02.17.480954 — immunology — Posted on 2022-02-18

1320 Mitochondrial and redox modifications in early stages of Huntington disease

Lopes, C.; Ferreira, I. L.; Maranga, C.; Beatriz, M.; Mota, S.; Sereno, J.; Castelhano, J.; Abrunhosa, A.; Oliveira, F.; De Rosa, M.; Hayden, M. R.; Laco, M.; Januario, C.; Castelo Branco, M.; Rego, A. C.

10.1101/2022.01.14.476381 — neuroscience — Posted on 2022-02-18

1321 The universal language network: A cross-linguistic investigation spanning 45 languages and 12 language families.

Malik-Moraleda, S.; Ayyash, D.; Gallee, J.; Affourtit, J.; Hoffmann, M.; Mineroff, Z.; Jouravlev, O.; Fedorenko, E.

10.1101/2021.07.28.454040 — neuroscience — Posted on 2022-02-18

1322 Blood Concentrations of Per- and Polyfluoroalkyl Substances are Associated with Lupus-like Autoimmunity in the American Alligator

Guillete, T.; Jackson, T. W.; Guillette, M.; MCCord, J.; Belcher, S. M.

10.1101/2022.02.15.480575 — pharmacology and toxicology — Posted on 2022-02-18

1323 Nuclear Receptor 5A2 Regulation of Agrp underlies Olanzapine-induced Hyperphagia

Zapata, R. C.; Zhang, D.; Libster, A.; Porcu, A.; Montilla-Perez, P.; Zhang, Z.; Correa, S. M.; Telese, F.; Osborn, O.

10.1101/2022.02.15.480590 — physiology — Posted on 2022-02-18

1324 Genetic and epigenetic driven variation in regulatory regions activitycontribute to adaptation and evolution under endocrine treatment

Slaven, N.; Lopes, R.; Canale, E.; Ivanoiu, D.; Pacini, C.; Monteiro Barbosa, I. A.; Bleu, M.; Bravaccini, S.; Ravaioli, S.; Dieci, M. V.; Pruneri, G.; Galli, G.; Barozzi, I.; Magnani, L.

10.1101/2022.02.15.480537 — cancer biology — Posted on 2022-02-18

1325 Reclassifying Cancer: Defining tumour cell cycle activity in terms of its tissue of origin in over 13,000 samples

Lundberg, A.; Yi, J. J. J.; Lindstrom, L. S.; Tobin, N. P.

10.1101/2022.02.15.480623 — cancer biology — Posted on 2022-02-18

1326 Design of a Versatile Microfluidic Device for Imaging Precision-Cut-Tissue Slices

Rafiei, N.; Au, A.; Moghaddam, M. G.; Regeenes, R.; Wang, Y.; Yip, C. M.; Gaisano, H.; Rocheleau, J. V.

10.1101/2022.02.15.480396 — bioengineering — Posted on 2022-02-18

1327 Neocentromere formation through Robertsonian fusion and centromere repositioning during the evolution of zebras

Cappelletti, E.; Piras, F. M.; Sola, L.; Santagostino, M.; Abdelgadir, W. A.; Raimondi, E.; Nergadze, s. G.; Giulotto, E.

10.1101/2022.02.15.480582 — genomics — Posted on 2022-02-18

1328 IKK2/NFkB signaling controls lung resident CD8 T cell memory during influenza infection

Teixeiro, E.; Pritzl, C. J.; Luera, D.; Knudson, K. M.; Quaney, M. J.; Daniels, M. A.

10.1101/2022.02.15.480615 — immunology — Posted on 2022-02-18

1329 Leishmania amazonensis infection induces PD-L1 expression on dendritic cells in an mTor-dependent manner and impairs Th1 responses in vitro and in vivo

de Matos Guedes, H. L.; da Fonseca-Martins, A. M.; Liang, Y.; Carlsen, E. D.; Henard, C. A.; Pinchuk, I. V.; Soong, L.

10.1101/2022.02.15.480617 — immunology — Posted on 2022-02-18

1330 A two-gene strategy increases the iron and zinc concentration of wheat flour and improves mineral bioaccesibility for human nutrition.

Harrington, S. A.; Connorton, J. M.; Nyangoma, N. I.; McNelly, R.; Morgan, Y. M.; Aslam, M. F.; Sharp, P. A.; Johnson, A. A.; Uauy, C.; Balk, J.

10.1101/2022.02.15.480518 — plant biology — Posted on 2022-02-18

1331 Cold-inducible promoter-driven knockdown of Brachypodium antifreeze proteins confers freeze sensitivity

Juurakko, C. L.; Bredow, M.; diCenzo, G. C.; Walker, V. K.

10.1101/2022.02.15.480542 — plant biology — Posted on 2022-02-18

1332 Fibrosis resolution involves more than collagen; new potential players of fibrosis recovery in mouse liver

Sato, T.; Head, K. Z.; Li, J.; Dolin, C. E.; Wilkey, D.; Skirtich, N.; McCreary, D. D.; Beier, J. I.; McEnaney, R. M.; Merchant, M. L.; Arteel, G. E.

10.1101/2022.02.15.480540 — pathology — Posted on 2022-02-18

1333 Comparative evaluation of glomerular morphometric techniques reveals differential technical artefacts between FSGS and normal glomeruli

Basgen, J. M.; Reghuvaran, A. C.; Lin, Q.; Banu, K.; Shi, H.; Pell, J.; DiRito, J.; Tietjen, G. T.; Perincheri, S.; Moledina, D. G.; Wilson, F. P.; Menon, M. C.

10.1101/2022.02.15.480420 — pathology — Posted on 2022-02-18

1334 Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

Boot, J.; Rosser, G.; Kancheva, D.; Vinel, C.; Lim, Y. M.; Pomella, N.; Zhang, X.; Guglielmi, L.; Sheer, D.; Barnes, M.; Brandner, S.; Nelander, S.; Movahedi, K.; Marino, S.

10.1101/2022.02.15.480525 — cancer biology — Posted on 2022-02-18

1335 Interpretable and Generalizable Attention-Based Model for Predicting Drug-Target Interaction Using 3D Structure of Protein Binding Sites: SARS-CoV-2 Case Study and in-Lab Validation

Yazdani-Jahromi, M.; Yousefi, N.; Tayebi, A.; Garibay, O. O.; Seal, S.; Kolanthai, E.; Neal, C.

10.1101/2021.12.07.471693 — bioinformatics — Posted on 2022-02-18

1336 Depletion of Sun1/2 Induces Heterochromatin Accrual in Mesenchymal Stem Cells during Adipogenesis

Goelzer, M.; Howard, S.; Zavala, A.; Conway, D. E.; van Wijnen, A. J.; Uzer, G.

10.1101/2022.02.15.480528 — bioengineering — Posted on 2022-02-18

1337 Ionic remodelling following myocardial infarction explains phenotypic variability in ECG and arrhythmic substrate but not in ejection fraction

Zhou, X.; Wang, Z. J.; Camps, J.; Tomek, J.; Santiago, A.; Quintanas, A.; Vazquez, M.; Vaseghi, M.; Rodriguez, B.

10.1101/2022.02.15.480392 — bioengineering — Posted on 2022-02-18

1338 Spatial patterns of biomass change across Finland in 2009 - 2015

Haakana, M.; Tuominen, S.; Heikkinen, J.; Peltoniemi, M.; Lehtonen, A.

10.1101/2022.02.15.480479 — ecology — Posted on 2022-02-18

1339 Arbidol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

Liu, K.; Dong, Z.; Yang, N.; Lu, X.; Jiang, Y.; Zhao, L.; Wang, D.; Wei, Y.; Yu, Y.; Kim, M. O.; Laster, K. V.; Li, X.; Yuan, B.

10.1101/2022.02.15.480509 — cancer biology — Posted on 2022-02-18

1340 Tensor decomposition reveals coordinated multicellular patterns of transcriptional variation that distinguish and stratify disease individuals

Mitchel, J.; Gordon, M. G.; Perez, R. K.; Biederstedt, E.; Bueno, R.; Ye, C. J.; Kharchenko, P.

10.1101/2022.02.16.480703 — bioinformatics — Posted on 2022-02-18

1341 On Correlation between Structural Properties and Viral Escape Measurements from Deep Mutational Scanning

Zhang, L.; Domeniconi, G.; Yang, C.-C.

10.1101/2022.02.17.480939 — bioinformatics — Posted on 2022-02-18

1342 Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

Czarna, A.; Plewka, J.; Kresik, L.; Matsuda, A.; Karim, A.; Robinson, C.; O Byrne, S.; Cunningham, F.; Georgiou, I.; Pachota, M.; Popowicz, G.; Wyatt, P. G.; Dubin, G.; Pyrc, K.

10.1101/2022.02.17.480845 — microbiology — Posted on 2022-02-18

1343 Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a host factor for RNA viruses including SARS-CoV-2

Devignot, S.; Sha, T. W.; Burkard, T. R.; Schmerer, P.; Hagelkruys, A.; Mirazimi, A.; Elling, U.; Penninger, J. M.; Weber, F.

10.1101/2022.02.17.480904 — microbiology — Posted on 2022-02-18

1344 Transcription factor retention through multiple polyploidisation steps in wheat

Evans, C. E.; Arunkumar, R.; Borrill, P.

10.1101/2022.02.15.480382 — plant biology — Posted on 2022-02-18

1345 New insights into tomato CLE peptide repertoire and perception mechanisms

Carbonnel, S.; Falquet, L.; Hazak, O.

10.1101/2022.01.21.477294 — plant biology — Posted on 2022-02-18

1346 Mitigation of Injury from Myocardial Infarction by TH1834, an Inhibitor of the Acetyltransferase Tip60

Wang, X.; Wan, T. C.; Kulik, K. R.; Lauth, A.; Lough, J. W.; Auchampach, J. A.

10.1101/2021.11.09.467996 — pharmacology and toxicology — Posted on 2022-02-18

1347 Abscisic Acid modulates neighbor proximity-induced leaf hyponasty in Arabidopsis

Michaud, O.; Johanna, K.; Galbier, F.; Lagier, M.; Galvao, V. C.; Ince, Y. c.; Trevisan, M.; Knerova, J.; Dickinson, P.; Hibberd, J. M.; Zeeman, S. C.; Fankhauser, C.

10.1101/2022.02.18.481016 — plant biology — Posted on 2022-02-18

1348 Autophagy promotes organelle clearance and organized cell separation of living root cap cells in Arabidopsis thaliana

Goh, T.; Sakamoto, K.; Wang, P.; Kozono, S.; Ueno, K.; Miyashima, S.; Toyokura, K.; Fukaki, H.; Kang, B. H.; Nakajima, K.

10.1101/2022.02.16.480624 — plant biology — Posted on 2022-02-18

1349 Autophagy promotes programmed cell death and corpse clearance in specific cell types of the Arabidopsis root cap

Feng, Q.; De Rycke, R.; Dagdas, Y.; Nowack, M. K.

10.1101/2022.02.16.480680 — plant biology — Posted on 2022-02-18

1350 LabGym: A versatile computational tool for automatic quantification of user-defined animal behaviors

Hu, Y.; Ferrario, C.; Ghimire, A.; Watson, B.; Iwasaki, K.; White, H.; Xi, Y.; Zhou, J.; Ye, B.

10.1101/2022.02.17.480911 — animal behavior and cognition — Posted on 2022-02-18

1351 SARS-CoV-2 variants show a gradual declining pathogenicity and pro-inflammatory cytokine spur, an increasing antigenic and anti-inflammatory cytokine induction, and rising structural protein instability

Barh, D.; Tiwari, S.; Gomes, L. G. R.; Pinto, C. H. R.; Andrade, B.; Ahmad, S.; Aljabali, A. A. A.; Alzahrani, K. J.; Banjer, H. J.; Hassan, S. S.; Tambuwala, M.; Redwan, E. M.; Raza, K.; Azevedo, V.; Lundstrom, K.; Uversky, V. N.

10.1101/2022.02.15.480592 — bioinformatics — Posted on 2022-02-18

1352 nPoRe: n-Polymer Realigner for improved pileup variant calling

Dunn, T.; Blaauw, D.; Das, R.; Narayanasamy, S.

10.1101/2022.02.15.480561 — bioinformatics — Posted on 2022-02-18

1353 Cell Intrinsic Control of Death and Proliferation of Lymphocytes in Immune Response and Tumor Cells by pH

Zeng, W.-p.

10.1101/2021.10.29.466539 — biochemistry — Posted on 2022-02-18

1354 mRNA 5' terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay

Thoreen, C.; van den Elzen, A.; Watson, M.

10.1101/2022.02.17.480814 — genetics — Posted on 2022-02-18

1355 E-cadherin is sorted by Rab7 and Snx16 for polarised secretion via Myosin V

Riechmann, V.; Tanasic, D.; Berns, N.

10.1101/2022.02.17.480827 — cell biology — Posted on 2022-02-18

1356 LncRNA RUS shapes the gene expression program towards neurogenesis

Schneider, M. F.; Müller, V.; Müller, S. A.; Lichtenthaler, S. F.; Becker, P. B. B.; Scheuermann, J. C.

10.1101/2022.02.17.480853 — molecular biology — Posted on 2022-02-18

1357 The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield

Villalta, A.; Schmitt, A.; Estrozi, L. F.; Quemin, E. R. J.; Lartigue, A.; Alempic, J.-M.; Prazak, V.; Belmudes, L.; Vasishtan, D.; Colmant, A. M. G.; Honore, F. A.; Coute, Y.; Grünewald, K.; Abergel, C.

10.1101/2022.02.17.480895 — microbiology — Posted on 2022-02-18

1358 The Achilles' heel of coronaviruses: targeting the 5' Polyuridines tract of the antigenome to inhibit Mouse coronavirus-induced cell death

Ullah, H.; Averick, S.; Tang, Q.

10.1101/2021.07.26.453908 — microbiology — Posted on 2022-02-18

1359 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Lauron, E.; Montiel-Ruiz, M.; Spreafico, R.; Noack, J.; Czudnochowski, N.; Sahakyan, A.; Pinto, D.; Saliba, C.; Culap, K.; Delotta, E.; Park, A.; Cameroni, E.; Ledoux, S.; Werts, A.; Colas, C.; Soriaga, L.; Telenti, A.; Purcell, L. A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.

10.1101/2021.03.09.434607 — immunology — Posted on 2022-02-18

1360 Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation

Zhou, S.; Liu, X.; Fang, X.; Chinchilli, V. M.; Wang, M.; Wang, H.-G.; Dokholyan, N. V.; Shen, C.; Lee, J. J.

10.1101/2021.11.20.469388 — pharmacology and toxicology — Posted on 2022-02-18

1361 Atypical MAPK regulates translocation of GATA transcription factor in response to chemoattractant stimulation

Hadwiger, J.; Cai, H.; Aranda, R.; Fatima, S.

10.1101/2022.02.17.480945 — developmental biology — Posted on 2022-02-18

1362 A network approach to genetic circuit designs

Crowther, M.; Wipat, A.; Goni-Moreno, A.

10.1101/2021.09.14.460206 — synthetic biology — Posted on 2022-02-18

1363 Conserved structures of neural activity in sensorimotor cortex of freely moving rats allow cross-subject decoding

Melbaum, S.; Russo, E.; Eriksson, D.; Schneider, A.; Durstewitz, D.; Brox, T.; Diester, I.

10.1101/2021.03.04.433869 — neuroscience — Posted on 2022-02-18

1364 De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet

Winkler, S. S.; Winkler, I.; Figaschewski, M.; Tiede, T.; Nordheim, A.; Kohlbacher, O.

10.1101/2021.05.11.443638 — systems biology — Posted on 2022-02-18

1365 A genetically linked pair of NLR immune receptors show contrasting patterns of evolution

Shimizu, M.; Hirabuchi, A.; Sugihara, Y.; Abe, A.; Takeda, T.; Kobayashi, M.; Hiraka, Y.; Kanzaki, E.; Oikawa, K.; Saitoh, H.; Langner, T.; Banfield, M. J.; Kamoun, S.; Terauchi, R.

10.1101/2021.09.01.458560 — plant biology — Posted on 2022-02-18

1366 Multi-omics Topic Modeling for Breast Cancer Classification

Valle, F.; Osella, M.; Caselle, M.

10.1101/2021.12.22.473851 — cancer biology — Posted on 2022-02-18

1367 F-actin bending facilitates net actomyosin contraction by inhibiting expansion with plus-end-located myosin motors

Tam, A. K. Y.; Mogilner, A.; Oelz, D. B.

10.1101/2021.10.03.462946 — biophysics — Posted on 2022-02-18

1368 Implementing the re-use of public DIA proteomics datasets: from the PRIDE database to Expression Atlas

Walzer, M.; Garcia-Seisdedos, D.; Prakash, A.; Brack, P.; Crowther, P.; Graham, R. L.; George, N.; Mohammed, S.; Moreno, P.; Papatheodorou, I.; Hubbard, S. J.; Vizcaino, J. A.

10.1101/2021.06.08.447493 — bioinformatics — Posted on 2022-02-18

1369 Visualization of SpoVAEa protein dynamics in dormant spores of Bacillus cereus and dynamic changes in their germinosomes and SpoVAEa during germination

Wang, Y.; Vischer, N. O. E.; Wekking, D.; Bogian, A.; Setlow, P.; BRUL, S.

10.1101/2022.01.10.475594 — microbiology — Posted on 2022-02-18

1370 Generated randomly and selected functionally? The nature of enterovirus recombination

Alnaji, F. G.; Bentley, K.; Pearson, A.; Woodman, A.; Moore, J. D.; Fox, H.; Macadam, A.; Evans, D.

10.1101/2020.09.29.319285 — microbiology — Posted on 2022-02-18

1371 Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behavior

Piantadosi, S. C.; Manning, E. E.; Chamberlain, B. L.; Hyde, J.; LaPalombara, Z.; Bannon, N. M.; Pierson, J. L.; K Namboodiri, V. M.; Ahmari, S. E.

10.1101/2022.02.17.480966 — neuroscience — Posted on 2022-02-18

1372 The gradient model of brain organization in decisions involving 'empathy for pain'

Labek, K.; Sittenberger, E.; Kienhoefer, V.; Rabl, L.; Messina, I.; Schurz, M.; Stingl, J. C.; Viviani, R.

10.1101/2021.11.28.470235 — neuroscience — Posted on 2022-02-18

1373 Dynamical interactions reconfigure the gradient of cortical timescales

Sorrentino, P.; Rabuffo, G.; Baselice, F.; Troisi Lopez, E.; Liparoti, M.; Quarantelli, M.; Sorrentino, G.; Bernard, C.; Jirsa, V.

10.1101/2020.10.23.350322 — neuroscience — Posted on 2022-02-18

1374 Mechanism of Voltage Gating in the Voltage-Sensing Phosphatase Ci-VSP

Shen, R.; Meng, Y.; Roux, B.; Perozo, E.

10.1101/2022.02.17.480971 — biophysics — Posted on 2022-02-18

1375 Molecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures

Lessen, H. J.; Sapp, K. C.; Beaven, A. H.; Ashkar, R.; Sodt, A. J.

10.1101/2022.02.17.480963 — biophysics — Posted on 2022-02-18

1376 The high-throughput perturbation of long non-coding RNA reveals functional features in stem cells and across cell-types

10.1101/2022.02.16.480297 — genomics — Posted on 2022-02-18

1377 A unique mineralizing pool of Gli1+ stem cells builds the tendon enthesis and demonstrates therapeutic potential

Fang, F.; Xiao, Y.; Zelzer, E.; Leong, K. W.; Thomopoulos, S.

10.1101/2022.02.17.480929 — developmental biology — Posted on 2022-02-18

1378 Follow that cell: leukocyte migration in L-plastin mutant zebrafish.

Linehan, J. B.; Zepeda, J. L.; Mitchell, T. A.; LeClair, E.

10.1101/2022.02.15.476948 — developmental biology — Posted on 2022-02-18

1379 Proteomic analysis of the actin cortex in interphase and mitosis

Vadnjal, N.; Nourreddine, S.; Lavoie, G.; Serres, M.; Roux, P. P.; Paluch, E. K.

10.1101/2022.02.16.480677 — cell biology — Posted on 2022-02-18

1380 In situ architecture of human kinetochore-microtubule interface visualized by cryo-electron tomography

Zhao, W.; Jensen, G. J.

10.1101/2022.02.17.480955 — cell biology — Posted on 2022-02-18

1381 Lens aquaporin-5 inserts into bovine fiber cell plasma membranes through mitochondria-associated lysosome secretion

Gletten, R. B.; Cantrell, L. S.; Schey, K. L.; Bhattacharya, S.

10.1101/2022.02.16.480789 — cell biology — Posted on 2022-02-18

1382 Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression

Gorospe, C. M.; Herrera Curbelo, A.; Carvalho, G.; Marchhart, L.; Niedzwiecka, K.; Wanrooij, P. H.

10.1101/2022.02.18.480979 — cell biology — Posted on 2022-02-18

1383 Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance

Froehlich, F.; Gerosa, L.; Muhlich, J. L.; Sorger, P. K.

10.1101/2022.02.17.480899 — systems biology — Posted on 2022-02-18

1384 Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic Development

de la O, S.; Liu, Z.; Sun, H.; Yu, S. K.; Wong, D. M.; Chu, E.; Rao, S. A.; Eng, N.; Peixoto, G.; Bouza, J.; Shen, Y.; Knox, S. M.; Tward, A. D.; Gloyn, A. L.; Sneddon, J. B.

10.1101/2022.02.17.480942 — developmental biology — Posted on 2022-02-18

1385 Comparisons of cell proliferation and cell death across life histories in the hemichordate Schizocardium californicum

Bump, P.; Khariton, M.; Stubbert, C.; Moyen, N. E.; Yan, J.; Wang, B.; Lowe, C. J.

10.1101/2022.02.16.480686 — developmental biology — Posted on 2022-02-18

1386 Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract

Zhao, F.; Grimm, S. A.; Jia, S.; Yao, H. H.-C.

10.1101/2022.02.16.480738 — developmental biology — Posted on 2022-02-18

1387 Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan.

Hughes, S. M.; Escaleira, R. C.; Wanders, K.; Koth, J.; Wilkinson, D. G.; Xu, Q.

10.1101/2022.02.17.480906 — developmental biology — Posted on 2022-02-18

1388 Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte

Loh, M.; Dauvet, D.; Sanchez-Garrido, F.; Sadaouli, K.; Bernard, F.; Guichet, A.

10.1101/2022.02.16.480671 — developmental biology — Posted on 2022-02-18

1389 The C. elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator

Beacham, G. M.; Wei, D. T.; Beyrent, E.; Zhang, Y.; Zheng, J.; Camacho, M. M. K.; Florens, L.; Hollopeter, G.

10.1101/2022.02.15.480428 — cell biology — Posted on 2022-02-18

1390 The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level.

Kim, Y.; Afanasyev, A. Y.; Tolokh, I. S.; Sharakhov, I. V.; Onufriev, A. V.

10.1101/2022.02.17.480932 — cell biology — Posted on 2022-02-18

1391 A centimeter-long bacterium with DNA compartmentalized in membrane-bound organelles

Volland, J.-M.; Gonzalez-Rizzo, S.; Gros, O.; Tyml, T.; Ivanova, N.; Schulz, F.; Goudeau, D.; Elisabeth, N.; Nath, N.; Udwary, D.; Malmstrom, R.; Guidi-Rontani, C.; Bolte-Kludge, S.; Davies, K. M.; Jean, M. R.; Mansot, J.-L.; Mouncey, N.; Angert, E.; Woyke, T.; Date, S.

10.1101/2022.02.16.480423 — cell biology — Posted on 2022-02-18

1392 Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events trigger two-step maturation

Cason, S. E.; Mogre, S. S.; Holzbaur, E. L. F.; Koslover, E. F.

10.1101/2022.02.17.480915 — cell biology — Posted on 2022-02-18

1393 Vps60 initiates formation of alternative membrane-bound ESCRT-III filaments

Pfitzner, A.-K.; Zivkovic, H.; humbert, f.; Roux, A.

10.1101/2022.02.16.480668 — cell biology — Posted on 2022-02-18

1394 CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model

Morera, C.; Kim, J.; Paredes-Redondo, A.; Nobles, M.; Rybin, D.; Moccia, R.; Kowala, A.; Meng, J.; Garren, S.; Liu, P.; Morgan, J. E.; Muntoni, F.; Christoforou, N.; Owens, J.; Tinker, A.; Lin, Y.-Y.

10.1101/2022.02.17.480850 — cell biology — Posted on 2022-02-18

1395 Minus one frameshifted puromycin N-acetyltransferase is targeted to the nucleolus: sporadic but reproducible chimera formation by a transfected Lc3b construct

Thekkinghat, A. A.; Rangarajan, P. N.

10.1101/2022.02.17.480764 — cell biology — Posted on 2022-02-18

1396 The Mycobacterium tuberculosis protein O-phosphorylation landscape

Frando, A.; Boradia, V.; Gritsenko, M.; Beltejar, M.-C.; Day, L.; Sherman, D. R.; Ma, S.; Jacobs, J. M.; Grundner, C.

10.1101/2022.02.17.480717 — microbiology — Posted on 2022-02-17

1397 Switchgrass metabolomics reveals striking genotypic and developmental differences in specialized metabolic phenotypes

Li, X.; Sarma, S. J.; Sumner, L. W.; Jones, A. D.; Last, R. L.

10.1101/2020.06.01.127720 — plant biology — Posted on 2022-02-17

1398 SERCA function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice

Cleverdon, R. E.; Whitley, K. C.; Marko, D. M.; Hamstra, S. I.; Braun, J. L.; Roy, B. D.; MacPherson, R. E.; Fajardo, V.

10.1101/2021.10.25.465805 — pathology — Posted on 2022-02-17

1399 The Pogonomyrmex californicus social niche polymorphism is a polygenic trait involving a young supergene

Errbii, M.; Ernst, U. R.; Lajmi, A.; Privman, E.; Gadau, J.; Schrader, L.

10.1101/2021.03.21.436260 — evolutionary biology — Posted on 2022-02-17

1400 How drought affects range and variability of environmental conditions in subtropical South African estuaries

Scharler, U. M.; Bownes, S.; Jerling, H.

10.1101/2022.02.17.480947 — ecology — Posted on 2022-02-17

1401 Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments

Lavenus, S. B.; Vosatka, K. W.; Caruso, A. P.; Ullo, M. F.; Khan, A.; Logue, J. S.

10.1101/2020.06.15.153007 — cell biology — Posted on 2022-02-17

1402 Urinary single-cell sequencing captures intrarenal injury and repair processes in human acute kidney injury

Klocke, J.; Kim, S. J.; Skopnik, C. M.; Hinze, C.; Boltengagen, A.; Metzke, D.; Grothgar, E.; Prskalo, L.; Wagner, L.; Freund, P.; Görlich, N.; Muench, F.; Schmidt-Ott, K. M.; Mashreghi, M.-F.; Kocks, C.; Eckardt, K.-U.; Rajewsky, N.; Enghard, P.

10.1101/2022.02.15.479234 — molecular biology — Posted on 2022-02-17

1403 MafB, WDR77, and ss-catenin interact with each other and have similar genome association profiles

He, L.; Gao, M.; Pratt, H.; Weng, Z.; Struhl, K.

10.1101/2022.02.17.480948 — molecular biology — Posted on 2022-02-17

1404 Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes

Venzon, M.; Das, R.; Luciano, D. J.; Burnett, J.; Park, H. S.; Devlin, J. C.; Kool, E. T.; Belasco, J. G.; Hubbard, E. J. A.; Cadwell, K.

10.1101/2021.08.02.454806 — microbiology — Posted on 2022-02-17

1405 Visualization of SpoVAEa protein dynamics in dormant spores of Bacillus cereus and dynamic changes in their germinosomes and SpoVAEa during germination

Wang, Y.; Vischer, N. O. E.; Wekking, D.; Bogian, A.; Setlow, P.; BRUL, S.

10.1101/2022.01.10.475594 — microbiology — Posted on 2022-02-17

1406 Sex differences in insular gyri responses to the cold pressor challenge

Krause-Sorio, B.; Macey, K. E.; Kumar, R.; Ogren, J. A.; Henderson, L. A.; Thomas, A.; Harper, R. M.; Macey, P. M.

10.1101/2022.02.17.480949 — neuroscience — Posted on 2022-02-17

1407 DARQ: Deep learning of quality control for stereotaxic registration of human brain MRI

Fonov, V.; Dadar, M.; The PREVENT-AD Research Group, ; ADNI, ; Collins, D. L.

10.1101/2021.08.16.456514 — neuroscience — Posted on 2022-02-17

1408 Behavioral decomposition reveals rich encoding structure employed across neocortex

Mimica, B.; Tombaz, T.; Battistin, C.; Guo Fuglstad, J.; Dunn, B. A.; Whitlock, J. R.

10.1101/2022.02.08.479515 — neuroscience — Posted on 2022-02-17

1409 Context coding in the mouse nucleus accumbens modulates motivationally relevant information

Gmaz, J.; van der Meer, M.

10.1101/2021.06.24.449720 — neuroscience — Posted on 2022-02-17

1410 PyRodentTracks: flexible computer vision and RFID based system for multiple rodent tracking and behavioral assessment.

Fong, T.; Jury, B.; Hu, H.; MURPHY, T. H.

10.1101/2022.01.23.477395 — neuroscience — Posted on 2022-02-17

1411 Substrate Temperature and Seed Scarification on Germination Parameters of Butterfly Pea (Clitoria ternatea)

Campbell, S. M.; Pearson, B.; Marble, S. C.

10.1101/2022.02.17.480912 — plant biology — Posted on 2022-02-17

1412 CBEA: Competitive balances for taxonomic enrichmentanalysis

Nguyen, Q. P.; Hoen, A. G.; Frost, H. R.

10.1101/2021.09.07.459294 — bioinformatics — Posted on 2022-02-17

1413 Scorepochs: a computer-aided scoring tool for resting-state M/EEG epochs

Fraschini, M.; La Cava, S. M.; Rodriguez, G.; Vitale, A.; Demuru, M.

10.1101/2020.05.26.116434 — bioengineering — Posted on 2022-02-17

1414 Sex differences in the immediate extinction deficit and renewal of extinguished fear in rats

Binette, A.; Totty, M.; Maren, S.

10.1101/2022.02.17.480946 — animal behavior and cognition — Posted on 2022-02-17

1415 Ecdysone coordinates plastic growth with robust pattern in the developing wing

Nogueira Alves, A.; Oliveira, M. M.; Koyama, T.; Shingleton, A.; Mirth, C.

10.1101/2020.12.16.423141 — developmental biology — Posted on 2022-02-17

1416 Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms

Chen, X.; Calandrelli, R.; Girardini, J.; Yan, Z.; Tan, Z.; Xu, X.; Hiniker, A.; Zhong, S.

10.1101/2022.02.15.480384 — neuroscience — Posted on 2022-02-17

1417 Leukemia-intrinsic determinants of CAR-T response revealed by in vivo genome-wide CRISPR screening.

Ramos, A.; Koch, C. E.; Liu, Y.; Hellinger, R. D.; Kyung, T.; Larson, R. C.; Froese, J.; Goulet, D.; Doench, J. G.; Regev, A.; Maus, M. V.; Birnbaum, M. E.; Hemann, M.

10.1101/2022.02.15.480217 — cancer biology — Posted on 2022-02-17

1418 A new insight into MYC action: control of RNA polymerase II methylation and transcription termination

Scagnoli, F.; Palma, A.; Favia, A.; Scuoppo, C.; Illi, B.; Nasi, S.

10.1101/2022.02.17.480813 — cancer biology — Posted on 2022-02-17

1419 Molecular architecture of the human caveolin-1 complex

Porta, J. C.; Han, B.; Gulsevin, A.; Chung, J.; Peskova, Y.; Connolly, S.; Mchaourab, H.; Meiler, J.; Karakas, E.; Kenworthy, A. K.; Ohi, M. D.

10.1101/2022.02.17.480763 — biophysics — Posted on 2022-02-17

1420 Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.

Cupo, R. R.; Rizo, A.; Braun, G. A.; Tse, E.; Chuang, E.; Southworth, D. R.; Shorter, J.

10.1101/2022.02.17.480866 — biochemistry — Posted on 2022-02-17

1421 Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

Li, G.; Hu, Y.; Pei, S.; Meng, J.; Wang, J.; Wang, J.; Yue, S.; Wang, Z.; Wang, S.; Liu, X.; Weng, Y.; Peng, X.; Zhao, Q.

10.1101/2022.02.16.480777 — biochemistry — Posted on 2022-02-17

1422 Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

Guo, H.; Stamper, E. L.; Sato-Carlton, A.; Shimazoe, M. A.; Li, X.; Zhang, L.; Stevens, L.; Tam, K. J.; Dernburg, A. F.; Carlton, P. M.

10.1101/2022.02.16.480793 — cell biology — Posted on 2022-02-17

1423 The stationary phase-specific sRNA fimR2 is a multifunctional regulator of bacterial motility, biofilm formation and virulence

Raad, N.; Tandon, D.; Hapfelmeier, S.; Polacek, N.

10.1101/2022.02.17.480891 — molecular biology — Posted on 2022-02-17

1424 Molecular snapshots of drug release from tubulin over eleven orders of magnitude in time

10.1101/2022.02.17.480857 — molecular biology — Posted on 2022-02-17

1425 HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

Sapp, N. E.; Burge, N.; Cox, K.; Thapa, S.; Prakash, P.; Balasubramaniam, M.; Christensen, D.; Li, M.; Linderberger, J.; Kvaratskhelia, M.; Pandhare, J.; Craigie, R.; Sundquist, W. I.; Poirier, M. G.; Dash, C.

10.1101/2022.02.16.480507 — microbiology — Posted on 2022-02-17

1426 Vivaxin genes encode highly immunogenic non-variant antigens unique to the Trypanosoma vivax cell-surface

Romero-Ramirez, A.; Casas-Sanchez, A.; Autheman, D.; Duffy, C. W.; Teixeira, M. M. G.; Machado, R. Z.; Coombes, J.; Flynn, R. J.; Wright, G. J.; Jackson, A. P.

10.1101/2022.02.16.480502 — microbiology — Posted on 2022-02-17

1427 Mitochondrial mRNA localization is governed by translation kinetics and spatial transport

Arceo, X. G.; Koslover, E. F.; Zid, B. M.; Brown, A. I.

10.1101/2022.02.16.480701 — biophysics — Posted on 2022-02-17

1428 Benchmarking Peptide Structure Prediction with AlphaFold2

Gulsevin, A.; Meiler, J.

10.1101/2022.02.17.480937 — biophysics — Posted on 2022-02-17

1429 CriSNPr: a single interface for the curated and de-novo design of gRNAs for CRISPR diagnostics using diverse Cas systems

Chakraborty, D.; Ansari, A. H.; Kumar, M.; Sarkar, S.; Maiti, S.

10.1101/2022.02.17.479653 — bioinformatics — Posted on 2022-02-17

1430 Accelerating the Validation of Endogenous On-Target Engagement and In-cellulo Kinetic Assessment for Covalent Inhibitors of KRASG12C in Early Drug Discovery

Kantae, V.; Polanski, R.; Lewis, H.; Barratt, D.; SRINIVASAN, B.

10.1101/2022.02.17.480880 — biochemistry — Posted on 2022-02-17

1431 Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells

Gerdes, P.; Lim, S. M.; Ewing, A. D.; Larcombe, M. R.; Chan, D.; Sanchez-Luque, F. J.; Walkner, L.; James, C.; Knaupp, A. S.; Carreira, P. E.; Nefzger, C. M.; Lister, R.; Richardson, S. R.; Polo, J. M.; Faulkner, G. J.

10.1101/2022.02.16.480772 — genomics — Posted on 2022-02-17

1432 Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development

Hoermann, A.; Habtewold, T.; Selvaraj, P.; Del Corsano, G.; Capriotti, P.; Inghilterra, M. G.; Temesgen, K. M.; Christophides, G. K.; Windbichler, N.

10.1101/2022.02.15.480588 — genetics — Posted on 2022-02-17

1433 FAM21 is critical for TLR2-CLEC4E-mediated dendritic cell function against Candida albicans

Kulkarni, R.; Kasani, S. K.; Tsai, C.-Y.; Tung, S.-Y.; Yeh, K.-H.; Yu, C.-H. A.; Chang, W.

10.1101/2022.02.16.480635 — cell biology — Posted on 2022-02-17

1434 Mitochondrial genomes in Perkinsus decode conserved frameshifts in all genes

Gornik, S. G.; Flores, V.; Reinhardt, F.; Erber, L.; Douvropoulou, O.; Lassadi, I.; Einarsson, E.; Morl, M.; Git, A.; Stadler, P.; Pain, A.; Waller, R. F.

10.1101/2022.02.17.480897 — molecular biology — Posted on 2022-02-17

1435 A novel fluorescent multi-domain protein construct reveals the individual steps of the unfoldase action of Hsp70

Tiwari, S.; Fauvet, B.; Assenza, S.; De Los Rios, P.; Goloubinoff, P.

10.1101/2022.02.17.480908 — molecular biology — Posted on 2022-02-17

1436 Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

Stolovich-Rain, M.; Kumari, S.; Friedman, A.; Kirillov, S.; Socol, Y.; Billan, M.; Ranjan Pal, R.; Golding, P.; Oiknine-Djian, E.; Sirhan, S.; Bejerano Sagie, M.; Cohen-Kfir, E.; Elgrably-Weiss, M.; Zhou, B.; Ravins, M.; E Gatt, Y.; Das, K.; Zelig, O.; Wiener, R.; Wolf, D.; Elinav, H.; Strahilevitz, J.; Padawer, D.; Baraz, L.; Rouvinski, A.

10.1101/2022.02.17.480851 — microbiology — Posted on 2022-02-17

1437 CipA mediates complement resistance of Acinetobacter baumannii by formation of a Factor I-dependent quadripartite assemblage

Ries, J. I.; Hess, M.; Nouri, N.; Wichelhaus, T. A.; Goettig, S.; Falcone, F. H.; Kraiczy, P.

10.1101/2022.02.17.480811 — microbiology — Posted on 2022-02-17

1438 The Mycobacterium tuberculosis protein O-phosphorylation landscape

Frando, A.; Boradia, V.; Gritsenko, M.; Beltejar, M.-C.; Day, L.; Sherman, D. R.; Ma, S.; Jacobs, J. M.; Grundner, C.

10.1101/2022.02.17.480717 — microbiology — Posted on 2022-02-17

1439 Predicted structure of the hepatitis B virus polymerase reveals an ancient conserved protein fold

Tajwar, R.; Bradley, D. P.; Ponzar, N. L.; Tavis, J. E.

10.1101/2022.02.16.480762 — microbiology — Posted on 2022-02-17

1440 Cross-kingdom metagenomic profiling of Lake Hillier reveals pigment-rich polyextremophiles and wide-ranging metabolic adaptations

Sierra, M.; Ryon, K.; Tierney, B.; Foox, J.; Bhattacharya, C.; Afshin, E.; Butler, D.; Green, S.; Thomas, K.; Ramsdell, J.; Bivens, N.; McGrath, K.; Mason, C.; Tighe, S. W.

10.1101/2022.02.17.480683 — microbiology — Posted on 2022-02-17

1441 Distinct physiological responses of Coccolithus braarudii life cycle phases to light intensity and nutrient availability

Langer, G.; Jie, V. W.; Kottmeier, D.; Flori, S.; Sturm, D.; de Vries, J.; Harper, G.; Brownlee, C.; Wheeler, G. L.

10.1101/2022.02.17.480838 — microbiology — Posted on 2022-02-17

1442 Azithromycin possesses biofilm-inhibitory activity and potentiates non-bactericidal colistin methanesulfonate against Klebsiella pneumonia

Moshynets, O. V.; Baranovskyi, T. P.; Cameron, S.; Iugin, O. S.; Pokholenko, I.; Jordan, R.; Kamyshnyi, A.; Krikunov, A. A.; Potochilova, V. V.; Rudnieva, K. L.; Spiers, A.

10.1101/2022.02.17.480821 — microbiology — Posted on 2022-02-17

1443 A Random Forest Classifier Uses Antibody Responses to Plasmodium Antigens to Reveal Candidate Biomarkers of the Intensity and Timing of Past Exposure to Plasmodium falciparum

Berube, S.; Kobayashi, T.; Norris, D. E.; Ruczinski, I.; Moss, W. J.; Wesolowski, A.; Louis, T. A.

10.1101/2022.02.16.480705 — immunology — Posted on 2022-02-17

1444 Reconstitution and Expression of mcy Gene Cluster in The Model Cyanobacterium Synechococcus 7942 Reveals a Roll of MC-LR in Cell Division

Yanli, Z.; Chunling, X.; Hui, C.; Anqi, J.; Liang, Z.; Junli, Z.; Lixin, Z.; Qiang, W.

10.1101/2022.02.17.480855 — synthetic biology — Posted on 2022-02-17

1445 Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

Su, M.; Fleisher, T.; Grosheva, I.; Horev, M. B.; Olszewska, M.; Haim, B.; Plotnikov, A.; Carvalho, S.; Moskovitz, Y.; Minden, M.; Chapal-Ilani, N.; Papapetrou, E. P.; Dezorella, N.; Cheng, T.; Kaushansky, N.; Geiger, B.; Shlush, L. I.

10.1101/2022.02.15.479934 — cancer biology — Posted on 2022-02-17

1446 Genome-wide in vivo CRISPR screens identify GATOR1 as a TP53 induced tumour suppressor

Mizutani, S.; Potts, M. A.; Deng, Y.; Giner, G.; Diepstraten, S.; Kueh, A. J.; Pal, M.; Healey, G.; Tai, L.; Wilcox, S.; Wei, A.; Pomilio, G.; Liao, Y.; Papenfuss, A. T.; Kelly, G. L.; Shi, W.; Strasser, A.; Herold, M. J.

10.1101/2022.02.16.480657 — cancer biology — Posted on 2022-02-17

1447 Finding coarse and fine scale population structure in a coastal species: population demographics meets genomics

Catarino, D.; Jorde, P. E.; Rogers, L.; Albretsen, J.; Jahnke, M.; Mellerud, I.; Sodeland, M.; Andre, C.; Knutsen, H.

10.1101/2022.02.15.480495 — genomics — Posted on 2022-02-17

1448 Age and spatio-temporal variations in food resources modulate stress-immunity relationships in three populations of wild roe deer

Carbillet, J.; Hollain, M.; Rey, B.; Palme, R.; Pellerin, M.; Regis, C.; Geffre, A.; Duhayer, J.; Pardonnet, S.; Debias, F.; Merlet, J.; Lemaitre, J.-F.; Verheyden, H.; Gilot-Fromont, E.

10.1101/2022.02.15.480486 — ecology — Posted on 2022-02-17

1449 An efficient early-pooling protocol for environmental DNA metabarcoding

Ushio, M.; Furukawa, S.; Murakami, H.; Masuda, R.; Nagano, A. J.

10.1101/2022.02.15.480497 — ecology — Posted on 2022-02-17

1450 Transmission risk assessment of Aedes-borne arboviral diseases in Accra, Ghana

Akyea-Bobi, N. E.; Akorli, J.; Akporh, S. S.; Acquah-Baidoo, D.; Opoku, M.; Frempong, K.; Pi-Bansa, S.; Boakye, H. A.; Joannides, J.; Abudu, M.; Osei, J. H. N.; Pwalia, R.; Akorli, E. A.; Amlalo, G. K.; Bonney, K.; Quansah, R.; Dadzie, S. K.

10.1101/2022.02.14.480316 — ecology — Posted on 2022-02-17

1451 An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants

Du, W.; Hurdiss, D. L.; Drabek, D.; Mykytyn, A. Z.; Kaiser, F.; Gonzalez-Hernandez, M.; Munoz-Santos, D.; Lamers, M. M.; van Haperen, R.; Li, W.; Drulyte, I.; Wang, C.; Sola, I.; Armando, F.; Beythien, G.; Ciurkiewicz, M.; Baumgartner, W.; Guilfoyle, K.; Smits, T.; van der Lee, J.; van Kuppeveld, F. J. M.; van Amerongen, G.; Haagmans, B. L.; Enjuanes, L.; Osterhaus, A. D.; Grosveld, F.; Bosch, B. J.

10.1101/2022.02.17.480751 — microbiology — Posted on 2022-02-17

1452 A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models.

Narayan, R.; Sharma, M.; Yadav, R. T.; Biji, A.; Khatun, O.; Rajmani, R. S.; Sharma, P. R.; Jeyashankar, S.; Rani, P.; Rao, C. D.; Satchidanandam, V.; Das, S.; Agarwal, R.; Tripathi, S.

10.1101/2022.02.16.480801 — microbiology — Posted on 2022-02-17

1453 Multisensory integration of social signals by a pathway from the basal amygdala to the auditory cortex in maternal mice

Nowlan, A. C.; Kelahan, C.; Shea, S. D.

10.1101/2022.02.17.480854 — neuroscience — Posted on 2022-02-17

1454 Factors that affected the qualification of standardized residency training of internal medicine: a prospective longitudinal study

Sun, Y.; Xu, J.; Hu, L.; Qi, J.

10.1101/2022.02.15.480480 — scientific communication and education — Posted on 2022-02-17

1455 Locally adaptive temperature response of vegetative growth in Arabidopsis thaliana

Clauw, P.; Kerdaffrec, E.; Gunis, J.; Reichardt, I.; Nizhynska, V.; Koemeda, S.; Jez, J.; Nordborg, M.

10.1101/2022.02.15.480488 — plant biology — Posted on 2022-02-17

1456 The Amidella clade in Europe (Amanita Pers., Basidiomycota: Amanitaceae): clarification of the contentious Amanita valens and the importance of taxon-specific PCR primers for identification

Arraiano Castilho, R. M.; Silva, A. C.; Vila-Vicosa, C.; Castro, M. R.; Morgado, L. N.; Oliveira, P.

10.1101/2022.02.15.479696 — evolutionary biology — Posted on 2022-02-17

1457 Functional connectivity of the inferior frontal gyrus: A meta-analytic connectivity modeling study

Bulut, T.

10.1101/2022.02.17.480832 — neuroscience — Posted on 2022-02-17

1458 A call to rethink the cognitive benefits of physical exercise: An umbrella review of randomized controlled trials

Ciria, L. F.; Romn-Caballero, R.; Vadillo, M. A.; Holgado, D.; Luque-Casado, A.; Perakakis, P.; Sanabria, D.

10.1101/2022.02.15.480508 — neuroscience — Posted on 2022-02-17

1459 Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma

Vichaikul, S.; Gurrea-Rubio, M.; Amin, M. A.; Campbell, P. L.; Wu, Q.; Mattichak, M. N.; Brodie, W. D.; Palisoc, P. J.; Ali, M.; Muraoka, S.; Ruth, J. H.; Model, E. N.; Rohraff, D. M.; Hervoso, J. L.; Mao-Draayer, Y.; Fox, D. A.; Khanna, D.; Sawalha, A.; Tsou, P.-S.

10.1101/2020.08.07.242198 — pharmacology and toxicology — Posted on 2022-02-17

1460 Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

Tang, H.; Ke, Y.; Ma, H.; Han, L.; Wang, L.; Zong, H.; Yuan, Y.; Wang, Z.; He, Y.; Chang, Y.; Wang, S.; Liu, J.; Yue, Y.; Xu, W.; Zhang, X.; Wang, Z.; Yang, L.; Chen, H.; Bian, Y.; Zhang, B.; Liao, Y.; Yin, H.; Chen, Y.; Zhang, E.; Zhang, X.; Jiang, H.; Xie, Y.; Gilly, J.; Wu, M.; Sun, T.; Zhu, J.

10.1101/2022.01.17.475291 — cell biology — Posted on 2022-02-17

1461 Experimental reproducibility limits the correlation between mRNA and protein abundances in tumour proteomic profiles

Upadhya, S. R.; Ryan, C.

10.1101/2021.09.22.461108 — systems biology — Posted on 2022-02-17

1462 Bioinformatic analysis of B and T cell epitopes from SARS-CoV-2 Spike, Membrane and Nucleocapsid proteins as a strategy to assess possible cross-reactivity between emerging variants, including Omicron, and other human coronaviruses

Pacheco, D. L.; Saint Remy, S.; Garcia, M. G.; Rivera, T.; Lopez, C. R.

10.1101/2022.02.16.480759 — bioinformatics — Posted on 2022-02-17

1463 MetaNovo: a probabilistic approach to peptide discovery in complex mass spectrometry datasets

Potgieter, M. G.; Nel, A. J.; Fortuin, S.; Garnett, S.; Wendoh, J. M.; Tabb, D. L.; Mulder, N.; Blackburn, J.

10.1101/605550 — bioinformatics — Posted on 2022-02-17

1464 Biomechanical dependence of SARS-CoV-2 infections

Paul, A.; Kumar, S.; Kaoud, T.; Pickett, M. R.; Bohanon, A. L.; Zoldan, J.; Dalby, K. N.; Parekh, S. H.

10.1101/2022.02.17.479764 — bioengineering — Posted on 2022-02-17

1465 Variational phylodynamic inference using pandemic-scale data

Ki, C.; Terhorst, J.

10.1101/2022.02.10.479891 — evolutionary biology — Posted on 2022-02-17

1466 Development and maintenance of synaptic structure is mediated by the alpha-tubulin acetyltransferase MEC-17/αTAT1

Teoh, J.-S.; Wang, W.; Chandhok, G.; Pocock, R.; Neumann, B.

10.1101/522904 — cell biology — Posted on 2022-02-17

1467 SEC is an anti-angiogenic virulence factor that promotes Staphylococcus aureus Infective Endocarditis Independent of Superantigen Activity

Kinney, K. J.; Tang, S. S.; Wu, X.-J.; Tran, P. M.; Bharadwaj, N.; Gibson-Corley, K. N.; Forsythe, A. N.; Kulhankova, K.; Gumperz, J.; Salgado-Pabon, W.

10.1101/2019.12.13.875633 — microbiology — Posted on 2022-02-17

1468 Immunogenicity of SARS-CoV-2 trimetric spike protein associated to Poly(I:C) plus Alum

Santos, J. d.; Cruz, L. F.; Fonseca-Martins, A. M. d.; Maciel, D. O.; Perez, G. G.; Roncaglia-Pereira, V. A.; Dumard, C. H.; Guedes da Silva, F. H.; dos Santos, A. C. V.; Leandro, M. S.; Ferreira, J. R. M.; Pinto, K. G.; Conde, L.; Rodrigues, D. A. S.; Silva, M. V. M.; Alvim, R. G. F.; Lima, T. M.; Marsili, F. F.; Abreu, D. P. B. d.; Ferreira, O. C.; Borges, R. d. S. M.; Tanuri, A.; Souza, T. M. L.; Rossi-Bergmann, B.; Vale, A. M.; Silva, J. L.; de Oliveira, A. C.; Filardy, A. A.; Gomes, A. M. O.; de Matos Guedes, H. L.

10.1101/2021.10.05.461434 — immunology — Posted on 2022-02-17

1469 NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

Bueno, D.; Narayan Dey, P.; Schacht, T.; Wolf, C.; Wüllner, V.; Morpurgo, E.; Rojas-Charry, L.; Sessinghaus, L.; Leukel, P.; Sommer, C.; Radyushkin, K.; Schaefer, M.; Florin, L.; Gomez-Zepeda, D.; Tenzer, S.; Baumgart, J.; Stamm, P.; Daiber, A.; Horta, G.; Nardi, L.; Vasic, V.; Schmeisser, M. J.; Hellwig, A.; Oskamp, A.; Bauer, A.; Anand, R.; Reichert, A. S.; Ritz, S.; Peper, J.; Silies, M.; Frauenknecht, K. B. M.; Methner, A.

10.1101/2021.02.15.431234 — neuroscience — Posted on 2022-02-17

1470 Discovery of Flaviviridae-derived endogenous viral elements in shrew genomes provide novel insights into Pestivirus ancient history

Li, Y.; Bletsa, M.; Zisi, Z.; Boonen, I.; Gryseels, S.; Kafetzopoulou, L.; Webster, J. P.; Catalano, S.; Pybus, O. G.; Van de Perre, F.; Li, H.; Li, Y.; Li, Y.; Abramov, A.; Lymberakis, P.; Lemey, P.; Lequime, S.

10.1101/2022.02.11.480044 — microbiology — Posted on 2022-02-17

1471 A five-fold expansion of the global RNA virome reveals multiple new clades of RNA bacteriophages

Neri, U.; Wolf, Y. I.; Roux, S.; Camargo, A. P.; Lee, B. D.; Kazlauskas, D.; Chen, I. M.; Ivanova, N.; Allen, L. Z.; Paez-Espino, D.; Bryant, D. A.; Bhaya, D.; Krupovic, M.; RNA Virus Discovery Consortium, ; Dolja, V. V.; Kyrpides, N. C.; Koonin, E. V.; Gophna, U.

10.1101/2022.02.15.480533 — genomics — Posted on 2022-02-17

1472 Multiple parasitoid species enhance top-down control, but parasitoid performance is context-dependent

Thierry, M.; Pardikes, N. A.; Ximenez-Embrun, M. G.; Proudhom, G.; Hrcek, J.

10.1101/2021.07.16.452484 — ecology — Posted on 2022-02-17

1473 Strain-dependent induction of primary bile acid 7-dehydroxylation by cholic acid

Vico Oton, E.; Volet, C.; Jacquemin, N. L. M.; Meibom, K. L.; Bernier-Latmani, R.

10.1101/2022.02.15.480494 — microbiology — Posted on 2022-02-17

1474 Pro-resolving lipid mediators within brain esterified lipid pools are reduced in female rats chronically exposed to traffic-related air pollution or genetically susceptible to Alzheimer's Disease phenotype

Shen, Q.; Liang, N.; Patten, K. T.; Otoki, Y.; Valenzuela, A. E.; Wallis, C.; Bein, K. J.; Wexler, A. S.; Lein, P. J.; Taha, A. Y.

10.1101/2022.02.16.480656 — neuroscience — Posted on 2022-02-17

1475 Representations of complex contexts: A role for hippocampus

Dimsdale-Zucker, H. R.; Montchal, M. E.; Reagh, Z. M.; Wang, S.-F.; Libby, L. A.; Ranganath, C. R.

10.1101/766311 — neuroscience — Posted on 2022-02-17

1476 A comparative study of stress responses elicited by misfolded proteins targeted by bipartite or matrix-targeting signal sequences to yeast mitochondria

Narayana Rao, K. B.; Pandey, P.; Sarkar, R.; Ghosh, A.; Mansuri, S.; Ali, M.; Majumder, P.; Kumar, K. R.; Ray, A.; Raychaudhuri, S.; Mapa, K.

10.1101/2020.08.16.252734 — cell biology — Posted on 2022-02-17

1477 Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation.

Petrauskas, A.; Fortunati, D. L.; Singh, A.; Kandi, A. R.; Pothapragada, S. S.; Agrawal, K.; Huelsmeier, J.; Hillebrand, J.; Brown, G.; Chaturvedi, D.; Lee, J.; Lim, C.; Auburger, G.; VijayRaghavan, K.; Ramaswami, M.; Bakthavachalu, B.

10.1101/2022.02.15.480566 — neuroscience — Posted on 2022-02-17

1478 Normalization of aperiodic ECoG components indicates fine motor recovery after sensory cortical stroke in mice

Biskamp, J.; Isla Cainzos, S.; Higgen, F. L.; Gerloff, C.; Magnus, T.

10.1101/2022.02.16.480472 — neuroscience — Posted on 2022-02-17

1479 An electrophysiological and behavioral model of Paramecium, the "swimming neuron"

Elices, I.; Kulkarni, A.; Escoubet, N.; Pontani, L.-L.; Prevost, A. M.; Brette, R.

10.1101/2022.02.15.480485 — neuroscience — Posted on 2022-02-17

1480 Decision formation in parietal cortex transcends a fixed frame of reference

So, N.; Shadlen, M. N.

10.1101/2022.02.16.478899 — neuroscience — Posted on 2022-02-17

1481 Perceptual consequences of interocular imbalances in the duration of temporal integration

Chin, B. M.; Burge, J.

10.1101/2022.02.16.480712 — neuroscience — Posted on 2022-02-17

1482 Sleep duration and brain structure - phenotypic associations and genotypic covariance

Fjell, A.; Sorensen, O.; Wang, Y.; Amlien, I. K.; Baare, W.; Bartres-Faz, D.; Bertram, L.; Boraxbekk, C.-J.; Brandmaier, A.; Demuth, I.; Drevon, C. A.; Ebmeier, K.; Ghisletta, P.; Kievit, R. A.; Kuhn, S. A.; Madsen, K. S.; Mowinckel, A. M.; Nyberg, L.; Sexton, C.; Sole-Padulles, C.; Vidal-Pineiro, D.; Wagner, G.; Watne, L. O.; Walhovd, K. B.

10.1101/2022.02.15.480501 — neuroscience — Posted on 2022-02-17

1483 2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

Morgan, A.; Adank, D.; Johnson, K.; Butler, E.; Patel, S.

10.1101/2022.02.15.480609 — neuroscience — Posted on 2022-02-17

1484 Contribution of individual excitatory synapses on dendritic spines to electrical signaling

Weng, J.-Y.; Ceballos, C.; Zecevic, D.

10.1101/2022.02.15.480607 — neuroscience — Posted on 2022-02-17

1485 Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, X.; Buccino, A.; Saseendran Kumar, S.; Hierlemann, A.; Bartram, J.

10.1101/2022.02.16.480643 — neuroscience — Posted on 2022-02-17

1486 Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics

Huwiler, S.; Dominguez, M. C.; Huwyler, S.; Kiener, L.; Stich, F.; Sala, R.; Aziri, F.; Trippel, A.; Schmied, C.; Huber, R.; Wenderoth, N.; Lustenberger, C.

10.1101/2022.02.16.480303 — neuroscience — Posted on 2022-02-17

1487 Brain regional identity and cell type specificity landscape of human cortical organoid models

Magni, M.; Bossi, B.; Conforti, P.; Galimberti, M.; Dezi, F.; Lischetti, T.; He, X.; Barker, R. A.; Zuccato, C.; Espuny Camacho, I.; Cattaneo, E.

10.1101/2022.02.17.480833 — neuroscience — Posted on 2022-02-17

1488 Single-nucleus transcriptomic analysis reveals divergence of glial cells in peripheral somatosensory system between human and mouse

Zhang, D.; Wei, Y.; Liu, J.; Yang, Y.; Ou, M.; Chen, Y.; Shen, J.; Zhu, T.; Zhou, C.

10.1101/2022.02.15.480622 — neuroscience — Posted on 2022-02-17

1489 Structural insight into the individual variability architecture of the functional brain connectome

Sun, L.; Zhao, T.; Liang, X.; Duan, D.; Liu, J.; Chen, Y.; Wang, X.; Liao, X.; Xia, M.; He, Y.

10.1101/2022.02.16.480803 — neuroscience — Posted on 2022-02-17

1490 Targeting the fronto-parietal network using multifocal personalized transcranial alternating current stimulation to enhance motor sequence learning in healthy older adults

Draaisma, L. R.; Wessel, M. J.; Moyne, M.; Morishita, T.; Hummel, F. C.

10.1101/2022.02.16.480660 — neuroscience — Posted on 2022-02-17

1491 Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats

Tyler, R. E.; Bluitt, M. N.; Van Voorhies, K.; Ornelas, L. C.; Weinberg, B. Z.; Besheer, J.

10.1101/2022.02.16.480725 — neuroscience — Posted on 2022-02-17

1492 Botulinum neurotoxin accurately separates tonic vs phasic transmission and reveals heterosynaptic plasticity rules in Drosophila

Han, Y.; Chien, C.; Goel, P.; He, K.; Pinales, C.; Buser, C.; Dickman, D.

10.1101/2022.02.15.480429 — neuroscience — Posted on 2022-02-17

1493 Dissociable misconfigurations of striatal functional connectivity profiles in smokers

Korponay, C.; Stein, E. A.; Ross, T. J.

10.1101/2022.02.15.480576 — neuroscience — Posted on 2022-02-17

1494 Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths vulnerable to degeneration with age

Call, C. L.; Neely, S. A.; Early, J. J.; James, O. G.; Zoupi, L.; Williams, A. C.; Chandran, S.; Lyons, D. A.; Bergles, D. E.

10.1101/2022.02.16.480718 — neuroscience — Posted on 2022-02-17

1495 Metabotropic purinergic receptor profiles and calcium signalling in primary mice myoblasts differ depending on their muscle origin and are altered in cells with mutated dystrophin gene (mdx mice)

Rog, J.; Oksiejuk, A.; Gorecki, D. C.; Zablocki, K. O.

10.1101/2022.02.16.478175 — biochemistry — Posted on 2022-02-17

1496 Sequential increase of PHGDH expression with Alzheimer's pathology and symptoms

Chen, X.; Calandrelli, R.; Girardini, J.; Yan, Z.; Tan, Z.; Xu, X.; Hiniker, A.; Zhong, S.

10.1101/2022.02.15.480384 — neuroscience — Posted on 2022-02-17

1497 Inducing a mental context for associative memory formation with real-time fMRI neurofeedback

Collin, S. H. P.; van den Broek, P.; van Mourik, T.; Desain, P.; Doeller, C. F.

10.1101/2022.02.16.480602 — neuroscience — Posted on 2022-02-17

1498 Task-specific effects of biological sex and sex hormones on object recognition memories in a 6-hydroxydopamine-lesion model of Parkinson's disease in adult male and female rats

Pinizzotto, C. C.; Patwardhan, A.; Aldarondo, D.; Kritzer, M. F.

10.1101/2022.02.15.480556 — neuroscience — Posted on 2022-02-17

1499 Conflict- and error-related theta activities are coupled to BOLD signals in different brain regions

Beldzik, E.; Ullsperger, M.; Domagalik, A.; Marek, T.

10.1101/2022.02.15.480552 — neuroscience — Posted on 2022-02-17

1500 Synaptic basis of a sub-second representation of time

Barri, A.; Wiechart, M. T.; Jazayeri, M.; DiGregorio, D.

10.1101/2022.02.16.480693 — neuroscience — Posted on 2022-02-17

1501 Awake responses suggest inefficient dense coding in the mouse retina

Boissonnet, T.; Tripodi, M.; Asari, H.

10.1101/2022.02.15.480512 — neuroscience — Posted on 2022-02-17

1502 Perinatal Oxycodone Exposure Causes Long Term Sex-Dependent Changes in Sensory and Reward Processing in Adult Mice

Minakova, E.; Mikati, M. O.; Madasu, M. K.; Conway, S. M.; Baldwin, J. W.; Swift, R. G.; McCullough, K. B.; Dougherty, J. D.; Maloney, S. E.; Al-Hasani, R.

10.1101/2022.02.15.480568 — neuroscience — Posted on 2022-02-17

1503 Melanosomes degrade lipofuscin and precursors that are derived from photoreceptor membrane turnover in the retinal pigment epithelium--an explanation for the origin of the melanolipofuscin granule

Lyu, Y.; Tschulakow, A. V.; Schraermeyer, U. A.

10.1101/2022.02.16.480523 — neuroscience — Posted on 2022-02-17

1504 Vocal markers of autism: assessing the generalizability of machine learning models

Rybner, A.; Jessen, E. T.; Mortensen, M. D.; Larsen, S. N.; Grossman, R.; Bilenberg, N.; Cantio, C.; Jepsen, J. R. M.; Weed, E.; Simonsen, A.; Fusaroli, R.

10.1101/2021.11.22.469538 — bioinformatics — Posted on 2022-02-17

1505 A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins

Rapaport, D.; Drwesh, L.; Heim, B.; Graf, M.; Kehr, L.; Hansen-Palmus, L.; Franz-Wachtel, M.; Macek, B.; Kalbacher, H.; Buchner, J.

10.1101/2022.02.15.480587 — biochemistry — Posted on 2022-02-17

1506 Effect of lipopolysaccharide (LPS) on HAEC cells. Does nicotinamide N-methyltranferase sensitize HAEC cells to LPS?

Stepinska, O.; Dymkowska, D.; Mateuszuk, L.; Zablocki, K. O.

10.1101/2021.12.29.474421 — biochemistry — Posted on 2022-02-17

1507 A five-fold expansion of the global RNA virome reveals multiple new clades of RNA bacteriophages

10.1101/2022.02.15.480533 — genomics — Posted on 2022-02-17

1508 Transition to siblinghood causes substantial and long-lasting physiological stress reactions in wild bonobos

Behringer, V.; Berghänel, A.; Lee, S. M.; Fruth, B.; Hohmann, G.

10.1101/2022.02.14.480345 — evolutionary biology — Posted on 2022-02-17

1509 Condensation of a nuclear mRNA export factor regulates mRNA transport during stress

Heinrich, S.; Hondele, M.; Marchand, D.; Derrer, C. P.; Zedan, M.; Oswald, A.; Uliana, F.; Mancini, R.; Grunwald, D.; Weis, K.

10.1101/2022.01.30.478372 — cell biology — Posted on 2022-02-17

1510 Revisiting the origin of interleukin 1 (IL-1) based on biological activities of IL-1 in anamniotes and their sub-functionalization in amniotes

Hasel de Carvalho, E.; Bartok, E.; Stoelting, H.; Bajoghli, B.; Leptin, M.

10.1101/2022.02.15.480490 — immunology — Posted on 2022-02-17

1511 Network architecture producing swing to stance transitions in an insect walking system

Strohmer, B.; Mantziaris, C.; Kynigopoulos, D.; Manoonpong, P.; Bonde Larsen, L.; Büschges, A.

10.1101/2022.01.20.477058 — neuroscience — Posted on 2022-02-17

1512 Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning

Zhang, C.; Shi, M.; Kim, W.; Arif, M.; Klevstig, M.; Li, X.; Yang, H.; Bayram, C.; Bolar, I.; Tozlu, O. O.; Hacimuftuoglu, A.; Yildirim, S.; Wei, Y.; Shi, X.; Nielsen, J.; Turkez, H.; Uhlen, M.; Boren, J.; Mardinoglu, A.

10.1101/2022.02.15.480557 — systems biology — Posted on 2022-02-17

1513 Neutral competition within a long-lived population of symmetrically dividing cells shapes the clonal composition of cerebral organoids

Pflug, F. G.; Haendeler, S.; Esk, C.; Lindenhofer, D.; Knoblich, J. A.; von Haeseler, A.

10.1101/2021.10.06.463206 — developmental biology — Posted on 2022-02-17

1514 Autism is associated with inter-individual variations of gray and white matter morphology

Mei, T.; Forde, N. J.; Floris, D. L.; Dell'Acqua, F.; Stones, R.; Ilioska, I.; Durston, S.; Moessnang, C.; Banaschewski, T.; Holt, R. J.; Baron-Cohen, S.; Rausch, A.; Loth, E.; Oakley, B.; Charman, T.; Ecker, C.; Murphy, D. G. M.; the EU-AIMS LEAP group, ; Beckmann, C. F.; Llera, A.; Buitelaar, J. K.

10.1101/2022.02.16.480649 — neuroscience — Posted on 2022-02-17

1515 Postnatal environmental enrichment enhances memory by shaping hippocampal-prefrontal theta and gamma rhythms in diploid and trisomic female mice

Alemany-Gonzalez, M.; Vilademunt, M.; Gener, T.; Nebot, P.; Puig, M. V.

10.1101/2022.02.16.480741 — neuroscience — Posted on 2022-02-17

1516 Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration

Hansen, A. H.; Pauler, F. M.; Riedl, M.; Streicher, C.; Heger, A.; Laukoter, S.; Sommer, C.; Nicolas, A.; Hof, B.; Tsai, L.-H.; Ruelicke, T.; Hippenmeyer, S.

10.1101/2022.02.16.480659 — neuroscience — Posted on 2022-02-17

1517 Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling

Chao, D. H. M.; Kirchner, M. K.; Pham, C.; Foppen, E.; Denis, R. G. P.; Castel, J.; Morel, C.; Montalban, E.; Bui, L.-C.; Renault, J.; Mouffle, C.; Garcia-Caceres, C.; Tschop, M. H.; Li, D.; Martin, C.; Stern, J. E.; Luquet, S. H.

10.1101/2022.02.16.480737 — physiology — Posted on 2022-02-17

1518 Prediction of range expansion and estimation of dispersal routes of water deer (Hydropotes inermis) in the transboundary region between China, the Russian Far East and the Korean Peninsula

Li, Y.; PENG, Y.; MO, Y.; LEE, H.; LI, H.; ZHU, W.; DARMAN, Y.; LEE, D. K.; WANG, T.; SEDASH, G.; PANDEY, P.; BORZEE, A.

10.1101/2022.02.16.480706 — ecology — Posted on 2022-02-16

1519 Purely enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR

Feyrer, H.; Gurdap, C. O.; Marusic, M.; Schlagnitweit, J.; Petzold, K.

10.1101/2022.02.16.480708 — biochemistry — Posted on 2022-02-16

1520 GWAS in the Southern African context

Swart, Y.; van Eeden, G.; Uren, C.; van der Spuy, G.; Tromp, G.; Möller, M.

10.1101/2022.02.16.480704 — genetics — Posted on 2022-02-16

1521 Urinary single-cell sequencing captures intrarenal injury and repair processes in human acute kidney injury

10.1101/2022.02.15.479234 — molecular biology — Posted on 2022-02-16

1522 Reconstructing cell interactions and state trajectories in pancreatic cancer stromal tumoroids

Okuda, R.; Gjeta, B.; Popovic, D.; Manyard, A.; Yu, Q.; He, Z.; Santel, M.; Seimiya, M.; Morinaga, S.; Miyagi, Y.; Yamaguchi, T.; Ueno, Y.; Taniguchi, H.; Treutlein, B.; Camp, G.

10.1101/2022.02.14.480334 — cancer biology — Posted on 2022-02-16

1523 High-throughput detection and quantification of phosphatidylcholines and sphingomyelins from single cells by chip-based nanoelectrospray ionisation

Hancock, S. E.; Ding, E.; Johansson Beves, E.; Mitchell, T. W.; Turner, N.

10.1101/2022.02.15.479799 — biochemistry — Posted on 2022-02-16

1524 Deciphering Multi-way Interactions in the Human Genome

Dotson, G. A.; Lindsly, S. M.; Cicalo, A.; Chen, C.; Dilworth, S.; Ryan, C.; Jeyarajan, S.; Meixner, W.; Beckloff, N.; Surana, A.; Wicha, M.; Muir, L.; Rajapakse, I.

10.1101/2021.08.15.456363 — genomics — Posted on 2022-02-16

1525 Switches, stability and reversals: the evolutionary history of sexual systems in fish

Pla, S.; Benvenuto, C.; Capellini, I.; Piferrer, F.

10.1101/2021.01.25.428070 — evolutionary biology — Posted on 2022-02-16

1526 Extension of bacterial rDNA sequencing to concurrent epigenetic analysis and its application to 16S meta-epigenetics

Nishimura, M.; Tanaka, T.; Murata, S.; MIyabe, A.; Ishige, T.; Kawasaki, K.; Yokoyama, M.; Tojo-Nishimura, S.; Matsushita, K.

10.1101/2022.02.15.480630 — microbiology — Posted on 2022-02-16

1527 ScRNA-seq Identified the Metabolic Reprogramming of Human Colonic Immune Cells in Different Locations and Disease States

Zhao, Q.; Zhang, T.; Yang, H.

10.1101/2022.02.14.480452 — immunology — Posted on 2022-02-16

1528 Non-destructive chemical sensing within bulk soil using 1000 biosensors per gram of matrix

Fulk, E. M.; Gao, X.; Lu, L. C.; Redeker, K. R.; Masiello, C. A.; Silberg, J. J.

10.1101/2022.02.11.480126 — synthetic biology — Posted on 2022-02-16

1529 Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

Xu, W.; Billon, C.; Li, H.; Hayes, M.; Yu, K.; Losby, M.; Hampton, C. S.; Adeyemi, C. M.; Graves, A.; Nasiotis, E.; Fu, C.; Welch, R.; Evans, R. M.; Pei, L.; Walker, J. K.; Milosavljevic, A.; Burris, T.; Zhang, L.

10.1101/2022.02.14.480431 — pharmacology and toxicology — Posted on 2022-02-16

1530 A population-level statistic for assessing Mendelian behavior of genotyping-by-sequencing data from highly duplicated genomes

Clark, L. V.; Mays, W.; Lipka, A. E.; Sacks, E. J.

10.1101/2020.01.11.902890 — bioinformatics — Posted on 2022-02-16

1531 A Simple and Reproducible In-Vivo Rabbit Phonation Model for Glottic Insufficiency

Swift, W. M.; Churnin, I. T.; Hamdi, O. A.; Strumpf, A. M.; Koehn, H. A.; Cottler, P. S.; Daniero, J. J.

10.1101/2022.02.14.480391 — bioengineering — Posted on 2022-02-16

1532 Hypoxic response is driven by the BAF form of SWI/SNF

Tran, K. D.; Chakravarty, T.; Garzon, J.; Saraf, A.; Florens, L.; Washburn, M.; Dutta, A.

10.1101/2022.02.16.480689 — biochemistry — Posted on 2022-02-16

1533 Genomic Surveillance of Salmonella spp. in the Philippines, 2013-2014

Lagrada, M. L.; Argimon, S.; Borlasa, J. B.; Abad, J. P.; Gayeta, J. M.; Masim, M. L.; Olorosa, A. M.; Cohen, V.; Jeffrey, B.; Abu-Dahab, K.; Sia, S. B.; Hufano, C. M.; Stelling, J.; Holden, M. T. G.; Aanensen, D. M.; Carlos, C. C.; Philippines Antimicrobial Resistance Surveillance Program,

10.1101/2022.02.14.480363 — genomics — Posted on 2022-02-16

1534 TraDIS-validate: a method for curating ordered gene-replacement libraries

Goodall, E. C. A.; Morris, F. C.; McKeand, S. A.; Sullivan, R.; Warner, I. A.; Sheehan, E.; Boelter, G.; Icke, C.; Cunningham, A. F.; Cole, J. A.; Banzhaf, M.; Bryant, J. A.; Henderson, I. R.

10.1101/2022.02.16.479736 — genetics — Posted on 2022-02-16

1535 Understanding West Nile virus spread: Mathematical modelling to determine the mechanisms with the most influence on infection dynamics.

Fesce, E.; Marini, G.; Rosa, R.; Lelli, D.; Cerioli, M. P.; Chiari, M.; Farioli, M.; Ferrari, N.

10.1101/2022.02.15.480483 — ecology — Posted on 2022-02-16

1536 Land use change through the lens of macroecology: insights from Azorean arthropods and the Maximum Entropy Theory of Ecology

Brush, M. J.; Matthews, T.; Borges, P. A. V.; Harte, J.

10.1101/2021.09.14.460355 — ecology — Posted on 2022-02-16

1537 Xist expression impacts chromatin structure and YY1 mediated transcription of X-linked genes in hematopoietic progenitor cells

Yang, T.; Ou, J.; Yildirim, E.

10.1101/2022.02.16.480654 — cell biology — Posted on 2022-02-16

1538 Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments

Lavenus, S. B.; Vosatka, K. W.; Caruso, A. P.; Ullo, M. F.; Khan, A.; Logue, J. S.

10.1101/2020.06.15.153007 — cell biology — Posted on 2022-02-16

1539 MTG16 (CBFA2T3) regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors

Brown, R. E.; Jacobse, J.; Anant, S. A.; Blunt, K. M.; Chen, B.; Vega, P. N.; Jones, C. T.; Pilat, J. M.; Revetta, F.; Gorby, A. H.; Stengel, K. R.; Choksi, Y. A.; Palin, K.; Piazuelo, M. B.; Washington, M. K.; Lau, K. S.; Goettel, J. A.; Hiebert, S. W.; Short, S. P.; Williams, C. S.

10.1101/2021.11.03.467178 — cell biology — Posted on 2022-02-16

1540 Pathogen profiling of Australian rabbits by metatranscriptomic sequencing

Jenckel, M.; Hall, R. N.; Strive, T.

10.1101/2022.02.15.480619 — microbiology — Posted on 2022-02-16

1541 High-throughput profiling of natural acquired humoral immune response to a large panel of known and novel full length ectodomain P. falciparum merozoite vaccine candidates under reduced malaria transmission.

Ndegwa, D. N.; Tuju, J.; Chepsat, E.; Kimathi, R.; Mwai, K.; Nyamako, L.; Dieye, B.; Mosobo, M.; Deme, A. B.; Ndiaye, I. M.; Sy, M.; Diallo, M. A.; Diedhiou, Y.; Mbaye, A. M.; Wirth, D.; Ndiaye, D.; Osier, F.; Bei, A. K.

10.1101/2022.02.15.479108 — immunology — Posted on 2022-02-16

1542 Dissociable roles of theta and alpha in sub-second and supra-second time reproduction:An investigation of their links to depression and anxiety

Liang, M.; Lomayesva, S.; Isham, E.

10.1101/2022.02.14.480446 — neuroscience — Posted on 2022-02-16

1543 BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models

Park, S.; Roache, C. E.; Iffland, P. H.; Moldenhauer, H. J.; Matychak, K. K.; Plante, A. E.; Crino, P. B.; Meredith, A. L.

10.1101/2022.02.15.478992 — neuroscience — Posted on 2022-02-16

1544 The invasive land flatworm Obama nungara in La Reunion, a French island in the Indian Ocean, the first report of the species for Africa

Justine, J.-L.; Marie, A. D.; Gastineau, R.; Fourcade, Y.; Winsor, L.

10.1101/2022.02.14.480416 — zoology — Posted on 2022-02-16

1545 Creating De Novo Overlapped Genes

Logel, D. Y.; Jaschke, P. R.

10.1101/2022.02.15.480625 — synthetic biology — Posted on 2022-02-16

1546 Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma

Shin, J.; Parker, M.; Zhu, I.; Alanizi, A.; Rodriguez, C.; Liu, R.; Watchmaker, P.; Kalita, M.; Blecha, J.; Luu, J.; Wright, B.; Lapi, S.; Flavell, R.; Okada, H.; Tlsty, T.; Wilson, D.; Roybal, K.

10.1101/2022.02.16.480729 — synthetic biology — Posted on 2022-02-16

1547 Ingestible capsule for detecting labile inflammatory biomarkers in situ

Inda, M. E.; Jimenez, M.; Liu, Q.; Phan, N.; Ahn, J.; Steiger, C.; Wentworth, A.; Riaz, A.; Zirtiloglu, T.; Wong, K.; Ishida, K.; Fabian, N.; Jenkins, J.; Kuosmanen, J.; Madani, W.; McNally, R.; Lai, Y.; Mimee, M.; Nadeau, P.; Chandrakasan, A.; Hayward, A.; Traverso, G.; Yazicigil, R. T.; Lu, T. K.

10.1101/2022.02.16.480562 — synthetic biology — Posted on 2022-02-16

1548 Spatially Resolved and Highly Complexed Protein and RNA in situ Detection by Combining CODEX with RNAscope In Situ Hybridization

Cheng, Y.; Burrack, R. M.; Li, Q.

10.1101/2022.02.10.479971 — pathology — Posted on 2022-02-16

1549 Targeting OLIG2 increases therapeutic responses in SHH medulloblastoma mouse models and patient-derived medulloblastoma organoids

Li, Y.; Dismuke, T.; Lim, C.; Bruce, Z. C.; Offenhauser, C.; Baumgartner, U.; Maybury, M.; DSouza, R. C. J.; Hassall, T.; Wainwright, B.; Stein, G.; Piper, M.; Johns, T. G.; Sokolsky-Papkov, M.; Gershon, T. R.; Day, B. W.

10.1101/2022.02.14.480293 — cancer biology — Posted on 2022-02-16

1550 Clustered transposon insertion via formation of chromatin loops

Prizak, R.; Hilbert, L.

10.1101/2022.02.16.480760 — biophysics — Posted on 2022-02-16

1551 Proteomic network analysis of bronchoalveolar lavage fluid in ex-smokers to discover implicated protein targets and novel drug treatments for chronic obstructive pulmonary disease

Mammen, M. J.; Tu, C.; Morris, M. C.; Richman, S.; Mangione, W.; Falls, Z.; Qu, J.; Broderick, G.; Sethi, S.; Samudrala, R.

10.1101/2022.02.14.480388 — bioinformatics — Posted on 2022-02-16

1552 Monitoring the quality of eggs depending on the hens breeding systems by Raman spectroscopy.

Abramczyk, H.; Kopec, M.

10.1101/2022.02.16.480636 — biochemistry — Posted on 2022-02-16

1553 Substrate topology and cognate immunity modulate antibacterial toxicity of Tae cell wall hydrolases

Radkov, A.; Sapiro, A.; Flores, S.; Henderson, C.; Saunders, H.; Kim, R.; Massa, S.; Thompson, S.; Mateusiak, C.; Biboy, J.; Zhao, Z.; Starita, L. M.; Hatleberg, W.; Vollmer, W.; Russell, A. B.; Simorre, J.-P.; Anthony-Cahill, S.; Brzovic, P.; Hayes, B.; Chou, S.

10.1101/2022.02.15.480620 — biochemistry — Posted on 2022-02-16

1554 A small molecule probe elucidates the role of mitochondrial translocase TIMM44 in PINK1/Parkin regulated mitophagy

Conti, M. A.; Torres, E. R.; van der Bliek, A. M.; Koehler, C.

10.1101/2022.02.16.480676 — biochemistry — Posted on 2022-02-16

1555 The Genetic and Evolutionary Basis of Gene Expression Variation in East Africans

Kelly, D. E.; Ramdas, S.; Ma, R.; Rawlings-Goss, R. A.; Grant, G. R.; Ranciaro, A.; Hirbo, J. B.; Beggs, W.; Yeager, M.; Chanock, S.; Nyambo, T. B.; Omar, S. A.; Meskel, D. W.; Belay, G.; Li, H.; Brown, C. D.; Tishkoff, S. A.

10.1101/2022.02.16.480765 — genomics — Posted on 2022-02-16

1556 Modeling exercise using optogenetically contractible Drosophila larvae

Ghosh, A. C.; Liu, Y.; Tattikota, S. G.; Hu, Y.; Perrimon, N.

10.1101/2022.02.16.480715 — genomics — Posted on 2022-02-16

1557 A model of functionally buffered deleterious mutations can lead to signatures of positive selection distinguishable from an evolutionary conflict model

Shen, R.; Wenzel, M.; Messer, P. W.; Aquadro, C. F.

10.1101/2022.02.14.480440 — genetics — Posted on 2022-02-16

1558 Hoisted with his own petard: how sex-ratio meiotic drive in Drosophila affinis creates resistance alleles that limit its spread

Ma, W.-J.; Patch, K. B.; Knoles, E. M.; Shoaib, M. M.; Unckless, R. L.

10.1101/2022.02.14.480432 — evolutionary biology — Posted on 2022-02-16

1559 Optimal resistance management for mixtures of high-risk fungicides: robustness to the initial frequency of resistance and pathogen sexual reproduction

Taylor, N.; Cunniffe, N.

10.1101/2022.02.14.480407 — evolutionary biology — Posted on 2022-02-16

1560 Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila

Tikhonova, E.; Mariasina, S.; Efimov, S.; Polshakov, V.; Maksimenko, O.; Georgiev, P.; Bonchuk, A.

10.1101/2022.02.16.480628 — molecular biology — Posted on 2022-02-16

1561 A single 2'-O-methylation of ribosomal RNA gates assembly of a functionalribosome

Yelland, J. N.; Bravo, J. P. K.; Black, J. J.; Taylor, D. W.; Johnson, A.

10.1101/2022.02.16.480697 — molecular biology — Posted on 2022-02-16

1562 The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway

Carreno, A.; Lykke-Andersen, J.

10.1101/2022.02.15.480631 — molecular biology — Posted on 2022-02-16

1563 Target-enrichment sequencing yields valuable genomic data for difficult-to-culture bacteria of public health importance

Dennis, T. P. W.; Mable, B. K.; Brunelle, B.; Devault, A.; Carter, R.; Ling, C. L.; Mmbaga, B. T.; Halliday, J. E. B.; Oravcova, K.; Forde, T. L.

10.1101/2022.02.16.480634 — molecular biology — Posted on 2022-02-16

1564 Mechanoregulation of biofilm architecture promotes Pseudomonas aeruginosa antibiotic tolerance.

Cont, A.; Vermeil, J.; Persat, A.

10.1101/2022.02.16.480709 — microbiology — Posted on 2022-02-16

1565 Multi-state occupancy model estimates probability of detection of an aquatic parasite using environmental DNA: Pseudoloma neurophilia in zebrafish aquaria

Schuster, C. J.; Kent, M.; Peterson, J.; Sanders, J.

10.1101/2022.02.16.480730 — microbiology — Posted on 2022-02-16

1566 Experimental infection of mink with SARS-COV-2 Omicron (BA.1) variant leads to symptomatic disease with lung pathology and transmission

10.1101/2022.02.16.480524 — microbiology — Posted on 2022-02-16

1567 International spread of emerging multidrug-resistant Rhodococcus equi

Val-Calvo, J.; Darcy, J.; Gibbons, J.; Creighton, A.; Egan, C.; Buckley, T.; Schmalenberger, A.; Fogarty, U.; Scortti, M.; Vazquez-Boland, J. A.

10.1101/2022.02.15.480578 — microbiology — Posted on 2022-02-16

1568 Bacterial community dynamics explain carbon mineralization and assimilation in soils of different land-use history

Barnett, S. E.; Youngblut, N. D.; Buckley, D. H.

10.1101/2022.02.16.480692 — microbiology — Posted on 2022-02-16

1569 Lin28b specifies an innate-like lineage of CD8+ T cells in early life

Watson, N.; Patel, R.; Oyesola, O.; Laniewski, N.; Grenier, J.; Wang, J.; Tabilas, C.; Mon, K. J. Y.; Peng, S.; Wesnak, S.; Nzingha, K.; Smith, N.; Davenport, M.; Wojno, E. T.; Scheible, K.; Grimson, A.; Rudd, B.

10.1101/2022.02.14.480406 — immunology — Posted on 2022-02-16

1570 Immune cell regulation in stem cell niche contacting glioblastomas.

Bartkowiak, T.; Lima, S. M.; Hayes, M. J.; Mistry, A. M.; Sinnaeve, J.; Leelatian, N.; Roe, C. E.; Mobley, B. C.; Weaver, K. D.; Thompson, R. C.; Chambless, L. B.; Ihrie, R. A.; Irish, J. M.

10.1101/2022.02.16.480731 — immunology — Posted on 2022-02-16

1571 Mathematical model of a cytokine storm

Kareva, I.; Berezovskaya, F.; Karev, G.

10.1101/2022.02.15.480585 — immunology — Posted on 2022-02-16

1572 Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of MDMA

Ionescu, T. M.; Amend, M.; Watabe, T.; Hatazawa, J.; Maurer, A.; Reischl, G.; Pichler, B. J.; Wehrl, H. F.; Herfert, K.

10.1101/2022.02.14.480365 — neuroscience — Posted on 2022-02-16

1573 The impacts of anesthetic regimens on the middle cerebral artery occlusion outcomes in male rats

Mousavi, S. M.; Karimi-Haghighi, S.; Chavoshinezhad, S.; Pandamooz, S.; Belem-Filho, I. J. A.; Keshavarz, S.; Bayat, M.; Hooshmandi, E.; Rahimi Jaberi, A.; Salehi, M. S.; Borhani-Haghighi, A.

10.1101/2022.02.14.480371 — neuroscience — Posted on 2022-02-16

1574 A simple self-decoding model for neural coding

Bui, T. V.

10.1101/2022.02.12.480019 — neuroscience — Posted on 2022-02-16

1575 Improving functional recovery after severe spinal cord injury by a noninvasive dual functional approach of neuroprotection and neuromodulation

Zuo, Y.; Ye, J.; Cai, W.; Guo, B.; Chen, X.; Lin, L.; Jin, S.; Zheng, H.; Fang, A.; Qian, X.; Abdelrahman, Z.; Wang, Z.; Zhang, Z.; Yu, B.; Gu, X.; Wang, X.

10.1101/2022.02.14.478109 — neuroscience — Posted on 2022-02-16

1576 Functional and effective connectivity between dorsolateral prefrontal and subgenual anterior cingulate cortex depends on the timing of transcranial magnetic stimulation relative to the phase of prefrontal alpha EEG

Pantazatos, S. P.; McIntosh, J. R.; Saber, G. T.; Sun, X.; Doose, J.; Faller, J.; Lin, Y.; Teves, J. B.; Blankenship, A.; Huffman, S.; Goldman, R. I.; George, M. S.; Sajda, P.; Brown, T.

10.1101/2022.02.14.480466 — neuroscience — Posted on 2022-02-16

1577 The development of receptive field tuning properties in mouse binocular primary visual cortex

Tan, L.; Ringach, D. L.; Trachtenberg, J.

10.1101/2022.02.14.480401 — neuroscience — Posted on 2022-02-16

1578 Tideglusib mitigates dystrophic pathology in skeletal muscle and restores diastolic function in young D2 mdx mice

Hamstra, S. I.; Whitley, K. C.; Braun, J. L.; Hockey, B.; Silvera, S.; Baranowski, R. W.; Copeland, E. N.; Geromella, M. S.; Watson, C. J.; Cleverdon, R. E.; Vandenboom, R.; Roy, B. D.; MacNeil, A. J.; MacPherson, R. E.; Fajardo, V.

10.1101/2022.02.16.480726 — physiology — Posted on 2022-02-16

1579 Therapeutic resistance to FLT3 inhibition is driven by a novel ATM/mTOR pathway regulating oxidative phosphorylation

Park, H. J.; Gregory, M. A.; Zaberezhnyy, V.; Goodspeed, A.; Jordan, C. T.; Kieft, J. S.; DeGregori, J.

10.1101/2022.02.14.480468 — cancer biology — Posted on 2022-02-16

1580 A possible way to relate the effects of SARS-CoV-2 induced changes in transferrin to severe COVID-19 associated diseases

Telek, E.; Ujfalusi, Z.; Kemenesi, G.; Zana, B.; Jakab, F.; Lukacs, A.; Hild, G.

10.1101/2022.02.15.480603 — biophysics — Posted on 2022-02-16

1581 GMMchi: Gene Expression Clustering Using Gaussian Mixture Modeling

Liu, T.-C.; N. Kalugin, P.; L. Wilding, J.; Bodmer, W. F.

10.1101/2022.02.14.480329 — bioinformatics — Posted on 2022-02-16

1582 Microbiome Toolbox: Methodological approaches to derive and visualize microbiome trajectories

Dogra, S. K.; Banjac, J.; Sprenger, N.

10.1101/2022.02.14.479826 — bioinformatics — Posted on 2022-02-16

1583 Unbiased pangenome graphs

Garrison, E.; Guarracino, A.

10.1101/2022.02.14.480413 — bioinformatics — Posted on 2022-02-16

1584 SciViewer- An interactive browser for visualizing single cell datasets

Jain, D.; Hayat, S.; Li, X.; Charkaborty, J.; Srinivasa, P.; Cho, M.; Silverman, E. K.; Moore, H.; Kramann, R.; Biehlmann, A. L.

10.1101/2022.02.14.480435 — bioinformatics — Posted on 2022-02-16

1585 Time-dependent Role of Bisphosphonates on Atherosclerotic Plaque Calcification

Bakhshian Nik, A.; Ng, H. H.; Garcia Russo, M.; Iacoviello, F.; Shearing, P.; Bertazzo, S.; Hutcheson, J. D.

10.1101/2022.02.14.479950 — bioengineering — Posted on 2022-02-16

1586 Chemophototherapy Overcomes Doxorubicin Resistance in Human Ovarian Cancer Cells

Ghosh, S.; Chitgupi, U.; Sunar, U.; Lovell, J.

10.1101/2022.02.14.480412 — bioengineering — Posted on 2022-02-16

1587 Metabotropic purinergic receptor profiles and calcium signalling in primary mice myoblasts differ depending on their muscle origin and are altered in cells with mutated dystrophin gene (mdx mice)

Rog, J.; Oksiejuk, A.; Gorecki, D. C.; Zablocki, K. O.

10.1101/2022.02.16.478175 — biochemistry — Posted on 2022-02-16

1588 Comparative sub-cellular proteome analyses reveals metabolic differentiation and production of effector-like molecules in the dieback phytopathogen Phytophthora cinnamomi.

Andronis, C. E.; Jacques, S.; Lipscombe, R.; Tan, K.-C.

10.1101/2022.02.15.480627 — biochemistry — Posted on 2022-02-16

1589 Quantitatively defining species boundaries with moreefficiency and more biological realism

Douglas, J.; Bouckaert, R.

10.1101/2022.02.14.480439 — evolutionary biology — Posted on 2022-02-16

1590 Gut Microbiome Contributes to Cold-climate Adaptation in Lizards

Chen, J.-Q.; Zhang, L.-W.; Zhao, R.-M.; Wu, H.-X.; Lin, L.-H.; Li, P.; Li, H.; Qu, Y.-F.; Ji, X.

10.1101/2022.02.14.480473 — ecology — Posted on 2022-02-16

1591 Behavioral signatures of Y-like neuronal responses in human vision

Ramirez, A. L.; Thompson, L. W.; Rosenberg, A.; Baker, C. L.

10.1101/2022.02.14.480142 — neuroscience — Posted on 2022-02-16

1592 Utilising TMS-EEG to assess the response to cerebellar-brain inhibition

Sasaki, R.; Hand, B.; Liao, W.-y.; Rogasch, N. C.; Fernandez, L.; Semmler, J.; Opie, G. M.

10.1101/2022.02.14.480458 — neuroscience — Posted on 2022-02-16

1593 Clonally heritable gene expression imparts a layer of diversity within cell types

Mold, J. E.; Weissman, M.; Ratz, M.; Hagemann-Jensen, M.; Hard, J.; Eriksson, C.-J.; Toosi, H.; Bergenstrahle, J. A.; von Berlin, L.; Martin, M.; Blom, K.; Lagergren, J.; Lundeberg, J.; Sandberg, R.; Michaelsson, J.; Frisen, J.

10.1101/2022.02.14.480352 — systems biology — Posted on 2022-02-16

1594 Editing the CsDMR6 Gene in Citrus Results in Resistance to the Bacterial Disease Citrus Canker

Parajuli, S.; Huo, H.; Gmitter, F.; Duan, Y.; Luo, F.; Deng, Z.

10.1101/2022.02.14.480359 — plant biology — Posted on 2022-02-16

1595 A new pterosaur from Skye, Scotland and the early diversification of flying reptiles

Martin-Silverstone, E.; Unwin, D. M.; Cuff, A. R.; Brown, E. E.; Allington-Jones, L.; Barrett, P. M.

10.1101/2022.02.14.480264 — paleontology — Posted on 2022-02-16

1596 Robust statistical evaluation of tumor incidences in long-term rodent carcinogenicity studies: the reformulated poly-k trend test

Hothorn, L. A.

10.1101/2022.02.14.480341 — bioinformatics — Posted on 2022-02-16

1597 '4-Aminoquinazoline-6,7-diol' derivatives for enhanced EGFR binding (as inhibitor) against Lung cancer

Maurya, P. P.

10.1101/2022.02.14.480387 — bioinformatics — Posted on 2022-02-16

1598 Learning a new class of multisensory associations: High-density electrophysiological mapping of the temporal course of audio-visual object processing.

Vercillo, T.; Freedman, E. G.; Ewen, J. B.; Molholm, S.; Foxe, J. J.

10.1101/2021.11.15.468657 — neuroscience — Posted on 2022-02-16

1599 Dynamic regulation and requirement for ribosomal RNA transcription duringmammalian development

Terrazas Falcon, K.; Watt, K.; Dash, S.; Moore, E.; Zhao, R.; Fitriasari, S.; Sakai, D.; Childers, M.; Sardiu, M.; Swanson, S.; Tsuchiya, D.; Unruh, J.; Bugarinovic, G.; Li, L.; Shiang, R.; Achilleos, A.; Dixon, J.; Dixon, M.; Trainor, P.

10.1101/2021.09.22.461379 — developmental biology — Posted on 2022-02-16

1600 SARS-CoV-2 Omicron BA.2 Variant Evades Neutralization by Therapeutic Monoclonal Antibodies

Zhou, H.; Tada, T.; Dcosta, B. M.; Landau, N. R.

10.1101/2022.02.15.480166 — immunology — Posted on 2022-02-16

1601 SARS-CoV-2 variants show a gradual declining pathogenicity and pro-inflammatory cytokine stimulation and an increasing antigenic and anti-inflammatory cytokine induction

10.1101/2022.02.15.480592 — bioinformatics — Posted on 2022-02-16

1602 "Neighbourhood watch" model: embryonic epiblast cells assess positional information in relation to their neighbours

Lee, H. C.; Hastings, C.; de Oliveira, N. M. M.; Perez-Carrasco, R.; Page, K. M.; Wolpert, L.; Stern, C. D.

10.1101/2021.04.22.440894 — developmental biology — Posted on 2022-02-16

1603 Extracellular and intracellular components of the impedance of neural tissue

Bedard, C.; Piette, C.; Venance, L.; Destexhe, A.

10.1101/2021.08.05.455210 — neuroscience — Posted on 2022-02-16

1604 Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Manea, A. M. G.; Zilverstand, A.; Ugurbil, K.; Heilbronner, S. R.; Zimmermann, J.

10.1101/2021.10.05.463277 — neuroscience — Posted on 2022-02-16

1605 CulebrONT: a streamlined long reads multi-assembler pipeline for prokaryotic and eukaryotic genomes

Orjuela, J.; Comte, A.; Ravel, S.; Charriat, F.; Vi, T.; Sabot, F.; Cunnac, S.

10.1101/2021.07.19.452922 — bioinformatics — Posted on 2022-02-16

1606 Introducing CARATE: Finally speaking chemistry.

Kleber, J. M.

10.1101/2022.02.12.470636 — bioinformatics — Posted on 2022-02-16

1607 Variation in Plasmodium falciparum sexual commitment rates and responses to environmental modification

Stewart, L. B.; Freville, A.; Voss, T. S.; Baker, D. A.; Awandare, G. A.; Conway, D. J.

10.1101/2022.02.14.480314 — microbiology — Posted on 2022-02-16

1608 Bacterial and fungal communities experience rapid succession during the first year following a wildfire in a California chaparral.

Pulido-Chavez, M. F.; Randolph, J. W. J.; Zalman, C.; Larios, L.; Homyak, P. M.; Glassman, S. I.

10.1101/2021.12.07.471678 — microbiology — Posted on 2022-02-16

1609 Pitfalls in Post Hoc Analyses of Population Receptive Field Data

Stoll, S.; Infanti, E.; de Haas, B.; Schwarzkopf, D. S.

10.1101/2020.12.15.422942 — neuroscience — Posted on 2022-02-16

1610 Rapid evolution of seed dormancy during sunflower de-domestication

Hernandez, F.; Vercellino, R. B.; Pandolfo, C.; Mandel, J. R.; Presotto, A.

10.1101/2021.05.21.445131 — plant biology — Posted on 2022-02-16

1611 Electrocardiogram feature extraction and interval measurements using optimal representative cycles from persistent homology

Dlugas, H.

10.1101/2022.02.01.478609 — bioinformatics — Posted on 2022-02-16

1612 Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction

Pepin, A.-S.; Lafleur, C.; Lambrot, R.; Dumeaux, V.; Kimmins, S.

10.1101/2021.09.09.459659 — developmental biology — Posted on 2022-02-16

1613 The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis

Rai, M.; Carter, S. M.; Shefali, S. A.; Mahmoudzadeh, N. H.; Pepin, R.; Tennessen, J. M.

10.1101/2022.02.15.480380 — developmental biology — Posted on 2022-02-16

1614 Dynamic S-acylation of STIM1 is required for store-operated Ca 2+ entry

Kodakandla, G.; West, S. J.; Zhu, M. X.; Wang, Q.; Tewari, R.; Akimzhanov, A. M.; Boehning, D. F.

10.1101/2022.02.15.480522 — cell biology — Posted on 2022-02-16

1615 Signaling from the RNA sensor RIG-I is regulated by ufmylation

Snider, D. L.; Park, M.; Murphy, K. A.; Beachboard, D. C.; Horner, S. M.

10.1101/2021.10.26.465929 — immunology — Posted on 2022-02-16

1616 SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

Zaffagni, M.; Harris, J. M.; Patop, I. L.; Pamudurti, N. R.; Nguyen, S.; Kadener, S.

10.1101/2021.07.02.450964 — molecular biology — Posted on 2022-02-16

1617 Sperm morphology differences associated with pig fertility

Mandawala, A. A.; Skinner, B. M.; Walling, G. A.; Harvey, K. E.; Harvey, S. C.

10.1101/314708 — developmental biology — Posted on 2022-02-16

1618 Number and proportion of Plasmodium falciparum gametocytes vary from acute infection to chronic carriage despite unaltered sexual commitment rate

van Dijk, H.; Ferreira Lima, N.; Kampmann, M.; Gabel, M.; Dabbas, U.; Doumbo, S.; Cisse, H.; Li, S.; Jeninga, M.; Thomson Luque, R.; Doumtabe, D.; Petter, M.; Kayentao, K.; Ongoiba, A.; Bousema, T.; Crompton, P. D.; Traore, B.; Graw, F.; Portugal, S.

10.1101/2021.11.05.467456 — microbiology — Posted on 2022-02-16

1619 Updated vaccine protects from infection with SARS-CoV-2 variants, prevents transmission and is immunogenic against Omicron in hamsters

Sharma, S.; Vercruysse, T.; Sanchez-Felipe, L.; Kerstens, W.; Maes, P.; Abdelnabi, R.; Foo, C. S.; Lemmens, V.; Van Looveren, D.; Baele, G.; Weynand, B.; Lemey, P.; Neyts, J.; Thibaut, H. J.; Dallmeier, K.

10.1101/2021.11.12.468374 — microbiology — Posted on 2022-02-16

1620 Cytokinin oxidase/dehydrogenase family genes exhibit functional divergence and overlap in rice growth and development, especially in control of tillering

Rong, C.; Liu, Y.; Chang, Z.; Liu, Z.; Ding, Y.; Ding, C.

10.1101/2021.05.09.443313 — plant biology — Posted on 2022-02-16

1621 Distinguishing excess mutations and increased cell death based on variant allele frequencies

Gergely, T.; Schrempf, D.; Derenyi, I.; Szöllosi, G. J.

10.1101/2021.02.12.430830 — bioinformatics — Posted on 2022-02-16

1622 Scalable sequence database search using Partitioned Aggregated Bloom Comb-Trees

Marchet, C.; Limasset, A.

10.1101/2022.02.11.480089 — bioinformatics — Posted on 2022-02-16

1623 Lung evolution in vertebrates and the water-to-land transition

Cupello, C.; Hirasawa, T.; Tatsumi, N.; Yabumoto, Y.; Gueriau, P.; Isogai, S.; Matsumoto, R.; Saruwatari, T.; King, A.; Hoshino, M.; Uesugi, K.; Okabe, M.; Brito, P. M.

10.1101/2022.02.14.480340 — evolutionary biology — Posted on 2022-02-16

1624 Comprehensive analysis of Arabidopsis thaliana DNA polymerase epsilon catalytic subunit A and B mutants - an insight into differentially expressed genes and protein-protein interactions

Wickramasuriya, A.; Hewavithana, T. M.; de Silva, K. K.; Ullah, I.; Dunwell, J. M.

10.1101/2022.02.14.480442 — molecular biology — Posted on 2022-02-16

1625 Growth of the Radiotrophic Fungus Cladosporium sphaerospermum aboard the International SpaceStation and Effects of Ionizing Radiation

Shunk, G. K.; Gomez, X. R.; Kern, C.; Averesch, N. J. H.

10.1101/2020.07.16.205534 — microbiology — Posted on 2022-02-16

1626 Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

Kazmierski, J.; Friedmann, K.; Postmus, D.; Fischer, C.; Jansen, J.; Richter, A.; Bosquillon de Jarcy, L.; Schüler, C.; Sohn, M.; Sauer, S.; Drosten, C.; Saliba, A.-E.; Sander, L.; Niemeyer, D.; Goffinet, C.

10.1101/2022.02.15.480527 — immunology — Posted on 2022-02-16

1627 Sequentially-reduced representation of artificial neural network to determine cardiovascular intrinsic frequencies

Alavi, R.; Wang, Q.; Gorji, H.; Pahlevan, N. M.

10.1101/2022.02.14.480311 — bioengineering — Posted on 2022-02-16

1628 Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection

Borges, J. P.; Satra, R. S. R.; Volchuk, A.; Bugge, M.; Kilburn, B.; Goldenberg, N. M.; FLO, T. H.; Steinberg, B. E.

10.1101/2021.12.12.471765 — cell biology — Posted on 2022-02-16

1629 Improved fluorescent proteins for dual-color post-embedding CLEM

Peng, D.; Li, N.; He, W.; Kim, D. R.; Xu, T.; Zhang, M.; Xu, P.

10.1101/2022.02.16.480633 — biophysics — Posted on 2022-02-16

1630 Biologically informed deep learning to infer gene program activity in single cells

Lotfollahi, M.; Rybakov, S.; Hrovatin, K.; Hediyeh-zadeh, S.; Talavera-Lopez, C.; Misharin, A.; Theis, F. J.

10.1101/2022.02.05.479217 — bioinformatics — Posted on 2022-02-16

1631 Pushing the limits of HiFi assemblies reveals centromere diversity between two Arabidopsis thaliana genomes

Rabanal, F. A.; Graeff, M.; Lanz, C.; Fritschi, K.; Llaca, V.; Lang, M.; Carbonell-Bejerano, P.; Henderson, I.; Weigel, D.

10.1101/2022.02.15.480579 — genomics — Posted on 2022-02-16

1632 Birth Order Differences in Education Originate in Post-Natal Environments

Isungset, M. A.; Freese, J.; Andreassen, O.; Lyngstad, T. H.

10.1101/2021.06.01.446519 — genetics — Posted on 2022-02-16

1633 Phylogenomic discordance suggests polytomies along the backbone of the large genus Solanum

Gagnon, E.; Hilgenhof, R.; Orejuela, A.; McDonnell, A.; Sablok, G.; Aubriot, X.; Giacomin, L.; Gouvea, Y.; Bragionis, T.; Stehmann, J. R.; Bohs, L.; Dodsworth, S.; Martine, C. T.; Poczai, P.; Knapp, S.; Särkinen, T.

10.1101/2021.03.25.436973 — evolutionary biology — Posted on 2022-02-16

1634 Neural Representations of Self-Generated Thought during Think-aloud fMRI

Li, H.-X.; Lu, B.; Wang, Y.-W.; Li, X.-Y.; Zhu, Z.-C.; Chen, X.; Yan, C.-G.

10.1101/2022.02.15.480505 — neuroscience — Posted on 2022-02-16

1635 Impaired dendritic spine development in a zebrafish model of Fragile X

DeMarco, E. C.; Stoner, G. R.; Robles, E.

10.1101/2022.02.15.480580 — neuroscience — Posted on 2022-02-16

1636 BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models

Park, S.; Roache, C. E.; Iffland, P. H.; Moldenhauer, H. J.; Matychak, K. K.; Plante, A. E.; Crino, P. B.; Meredith, A. L.

10.1101/2022.02.15.478992 — neuroscience — Posted on 2022-02-16

1637 MicroRNAs are deeply linked to the emergence of the complex octopus brain

Zolotarov, G.; Fromm, B.; Legnini, I.; Ayoub, S.; Polese, G.; Maselli, V.; Chabot, P. J.; Vinther, J.; Styfhals, R.; Seuntjens, E.; Di Cosmo, A.; Peterson, K. J.; Rajewsky, N.

10.1101/2022.02.15.480520 — evolutionary biology — Posted on 2022-02-16

1638 The connectional anatomy of visual mental imagery: evidence from a patient with left occipito-temporal damage

Hajhajate, D.; Kaufmann, B.; Liu, J.; Siuda-Krzywicka, K.; Bartolomeo, P.

10.1101/2022.02.15.480510 — neuroscience — Posted on 2022-02-16

1639 Prolactin-induced AMPK stabilizes alveologenesis and lactogenesis through regulation of STAT5 signaling

Jinagal, S. L.; Shekhar, P.; Chandra, K.; Mutnuru, S. A.; Ramanan, N.; Foretz, M.; Benoit, V.; Bhat, R.; Rangarajan, A.

10.1101/2022.02.15.480514 — developmental biology — Posted on 2022-02-16

1640 The impact of hyperglycemia upon BeWo trophoblast cell metabolic function: A multi-OMICS and functional metabolic analysis

Easton, Z. J.; Luo, X.; Li, L.; Regnault, T. R.

10.1101/2022.02.15.480604 — developmental biology — Posted on 2022-02-16

1641 Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment

Rosowski, S. T.; Braehler, C.; Marder, M.; Akishiba, M.; Platen, A.; Ussar, S.; Theis, F.; Wiedenmann, S.; Meier, M.

10.1101/2022.02.15.480506 — developmental biology — Posted on 2022-02-16

1642 Directed differentiation of EA/TEF patient-derived induced pluripotent stem cells into esophageal epithelial organoids reveal SOX2 dysregulation at the anterior foregut stage

Raad, S.; David, A.; Sagniez, M.; Orfi, Z.; Dumont, N. A.; Smith, M.; Faure, C.

10.1101/2022.02.14.480418 — developmental biology — Posted on 2022-02-16

1643 Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

L. Kahn, M.; Sung, D. C.; Chen, X.; Chen, M.; Yang, J.; Schultz, S.; Babu, A.; Xu, Y.; Gao, S.; Keller, T.; Mericko, P.; Lee, M.; Yang, Y.; Scallan, J.

10.1101/2022.02.15.480503 — developmental biology — Posted on 2022-02-16

1644 Transcriptomic mapping of the metzincin landscape in human trophoblasts

Wächter, J.; Shannon, M. J.; Castellana, B.; Baltayeva, J.; Beristain, A. G.

10.1101/2022.02.15.480614 — developmental biology — Posted on 2022-02-16

1645 The Drosophila melanogaster enzyme glycerol-3-phosphate dehydrogenase 1 is required for oogenesis, embryonic development, and amino acid homeostasis

Rai, M.; Carter, S. H.; Shefali, S.; Mahmoudzadeh, N. H.; Pepin, R.; Tennessen, J. M.

10.1101/2022.02.15.480380 — developmental biology — Posted on 2022-02-16

1646 Canonical Wnt signaling promotes formation of somatic permeability barrier for proper germ cell differentiation

Chen, T.-A.; Lin, K.-Y.; Yang, S.-M.; Tseng, C.-Y.; Wang, Y.-T.; Lin, C.-H.; Luo, L.; Cai, Y.; Hsu, H.-J.

10.1101/2022.02.15.480616 — developmental biology — Posted on 2022-02-16

1647 Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal-fetal interface

Wang, Q.; Li, J.; Wang, S.; Deng, Q.; An, Y.; Xing, Y.; Dai, X.; Li, Z.; Ma, Q.; Wang, K.; Liu, C.; Yuan, Y.; Dong, G.; Zhang, T.; Yang, H.; Du, Y.; Hou, Y.; Ke, W.; Shang, Z.

10.1101/2022.02.15.479798 — developmental biology — Posted on 2022-02-16

1648 A gradient border model for cell fate decisions at the neural plate border

Thiery, A.; Buzzi, A. L.; Hamrud, E.; Cheshire, C.; Luscombe, N.; Briscoe, J.; Streit, A.

10.1101/2022.02.15.480567 — developmental biology — Posted on 2022-02-16

1649 Recombinant production of growth factors for application in cell culture

Venkatesan, M.; Semper, C.; Di Leo, R.; Mesa, N.; Stogios, P. J.; Savchenko, A. J.

10.1101/2022.02.15.480596 — cell biology — Posted on 2022-02-16

1650 Endometriotic Organoids as an In Vitro Model of Endometriotic Lesion Development.

Song, Y.; Burns, G. W.; Joshi, N. R.; Arora, R.; Kim, J. J.; Fazleabas, A. T.

10.1101/2022.02.15.480583 — cell biology — Posted on 2022-02-16

1651 Centriole growth is not limited by a finite pool of components, but is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL

Steinacker, T. L.; Wong, S.-S.; Novak, Z. A.; Saurya, S.; Gartenmann, L.; van Houtum, E. J. H.; Sayers, J. R.; Lagerholm, B. C.; Raff, J. W.

10.1101/2022.02.15.480489 — cell biology — Posted on 2022-02-16

1652 AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction

Zheng, S.; Wolff, G.; Greenan, G.; Chen, Z.; Faas, F. G. A.; Barcena, M.; Koster, A. J.; Cheng, Y.; Agard, D.

10.1101/2022.02.15.480593 — cell biology — Posted on 2022-02-16

1653 Modeling of protein conformational changes with Rosetta guided by limited experimental data

Sala, D.; del Alamo, D.; Mchaourab, H. S.; Meiler, J.

10.1101/2022.02.14.480383 — biophysics — Posted on 2022-02-16

1654 Versatile patterns in the actin cortex of motile cells: Self-organized pulses can coexist with macropinocytic ring-shaped waves

Yochelis, A.; Flemming, S.; Beta, C.

10.1101/2022.02.15.480577 — biophysics — Posted on 2022-02-16

1655 The exchange rates of amide and arginine guanidinium CEST in the mouse brain

Wang, K.; Sui, R.; Chen, L.; Li, Y.; Xu, J.

10.1101/2022.02.14.480399 — biophysics — Posted on 2022-02-16

1656 Probing local chromatin dynamics by tracking telomeres

Weiss, M.; Benelli, R.

10.1101/2022.02.15.480529 — biophysics — Posted on 2022-02-16

1657 Septins mediate a microtubule-actin crosstalk that enables actin growth on microtubules

Nakos, K.; Radler, M. R.; Kesisova, I. A.; Tomasso, M. R.; Padrick, S. B.; Spiliotis, E. T.

10.1101/2022.02.15.480618 — cell biology — Posted on 2022-02-16

1658 Destabilization of F-actin by Mechanical Stress Deprivation or Tpm3.1 Inhibition Promotes a Pathological Phenotype in Tendon Cells

Parreno, J.; Inguito, K. L.; Schofield, M. M.; Faghri, A. D.; Bloom, E.; Heino, M.; Elliott, D.

10.1101/2022.02.15.480605 — cell biology — Posted on 2022-02-16

1659 Mapping Protein-Protein Interactions Using Data-Dependent Acquisition Without Dynamic Exclusion

Zhang, S.; Larsen, B.; Colwill, K.; Wong, C. J.; Youn, J.-Y.; Gingras, A.-C.

10.1101/2022.02.15.480563 — systems biology — Posted on 2022-02-16

1660 A novel Fiji/ImageJ plugin for the rapid analysis of blebbing cells

Vosatka, K. W.; Lavenus, S. B.; Logue, J. S.

10.1101/2021.06.04.447112 — cell biology — Posted on 2022-02-15

1661 Cancer malignancy is correlated with up-regulation of PCYT2-mediated glycerol phosphate modification of α-dystroglycan

Umezawa, F.; Natsume, M.; Fukusada, S.; Nakajima, K.; Yamasaki, F.; Kawashima, H.; Kuo, C.-W.; Khoo, K.-H.; Shimura, T.; Yagi, H.; Kato, K.

10.1101/2021.10.25.465649 — biochemistry — Posted on 2022-02-15

1662 Nisin G is a novel nisin variant produced by a gut-derived Streptococcus salivarius

Lawrence, G. W.; Garcia-Gutierrez, E.; Walsh, C. J.; O'Connor, P. M.; Begley, M.; Cotter, P. D.; Guinane, C. M.

10.1101/2022.02.15.480493 — microbiology — Posted on 2022-02-15

1663 Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques

Wood, J.; Wong, E.; Joghee, R.; Balbaa, A.; Vitanova, K. S.; Vanshoiack, A.; Phelan, S.-L. J.; Launchbury, F.; Desai, S.; Tripathi, T.; Hanrieder, J.; Cummings, D. M.; Hardy, J.; Edwards, F. A.

10.1101/2022.01.26.477873 — neuroscience — Posted on 2022-02-15

1664 A small molecule that promotes cellular senescence prevents fibrogenesis and tumorigenesis in vitro

Youn, B.-S.; Meang, M. K.; Kim, S.; Kim, I.-H.; Kim, H.-S.

10.1101/2021.06.01.446522 — cell biology — Posted on 2022-02-15

1665 Biomechanical control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium

Mytlis, A.; Kumar, V.; Tao, Q.; Deis, R.; Hart, N.; Levy, K.; Masek, M.; Shawahny, A.; Ahmad, A.; Eitan, H.; Nather, F.; Adar-Levor, S.; Birnbaum, R.; Elia, N.; Bachmann-Gagescu, R.; Roy, S.; Elkouby, Y. M.

10.1101/2021.02.08.430249 — cell biology — Posted on 2022-02-15

1666 Pilotins are mobile T3SS components involved in assembly and substrate specificity of the bacterial type III secretion system

Wimmi, S.; Fleck, M.; Helbig, C.; Brianceau, C.; Langenfeld, K.; Szymanski, W.; Angelidou, G.; Glatter, T.; Diepold, A.

10.1101/2022.02.14.480308 — microbiology — Posted on 2022-02-15

1667 Rose flavor compound β-damascone regulates dendritic cell-mediated immunoresponses by modulating the NRF2 pathway and ameliorates contact hypersensitivity

Kodama, N.; Okada, H.; Nagata, K.; Ando, M.; Ito, N.; Hiroki, I.; Yashiro, T.; Ichihara, G.; Yamamoto, M.; Hachisu, M.; Nishiyama, C.

10.1101/2022.02.08.479651 — immunology — Posted on 2022-02-15

1668 Neural Mechanism of Hunger Gated Food-seeking and Evaluating

Lee, Y.; Kim, Y. B.; Kim, K. S.; Song, H. Y.; Jang, M.; Ha, D.-S.; Park, J. S.; Jung, S.-H.; Lee, J.; Kim, K. M.; Cheon, D.-H.; Baek, I.; Shin, M.-G.; Lee, E. J.; Kim, S. J.; Choi, H. J.

10.1101/2020.10.23.352187 — neuroscience — Posted on 2022-02-15

1669 BAI-Net: Individualized Anatomical Human Cerebral Cartography using Graph Convolutional Network

Ma, L.; Zhang, Y.; Zhang, H.; Cheng, L.; Zhuo, J.; Shi, W.; Lu, Y.; Li, W.; Wang, J.; Yang, Z.; Fan, L.; Jiang, T.

10.1101/2021.07.15.452577 — neuroscience — Posted on 2022-02-15

1670 Speech sound categorization: beyond auditory cortices

Preisig, B. C.; Riecke, L.; Hervais-Adelman, A.

10.1101/2021.10.08.463391 — neuroscience — Posted on 2022-02-15

1671 Localization of signaling receptors maximizes cellular informationacquisition in spatially-structured natural environments

Wang, Z. J.; Thomson, M.

10.1101/2021.07.01.450787 — systems biology — Posted on 2022-02-15

1672 High performance single-cell gene regulatory network inference at scale: The Inferelator 3.0

Skok Gibbs, C.; Jackson, C. A.; Saldi, G.-A.; Tjärnberg, A.; Shah, A.; Watters, A.; De Veaux, N.; Tchourine, K.; Yi, R.; Hamamsy, T.; Castro, D. M.; Carriero, N.; Gorissen, B. L.; Gresham, D.; Miraldi, E. R.; Bonneau, R.

10.1101/2021.05.03.442499 — systems biology — Posted on 2022-02-15

1673 Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

10.1101/2022.02.14.480426 — pharmacology and toxicology — Posted on 2022-02-15

1674 A hemifused complex is the hub in a network of pathways to membrane fusion

Warner, J.; An, D.; Stratton, B.; O'Shaughnessy, B.

10.1101/2021.06.20.449175 — biophysics — Posted on 2022-02-15

1675 Biochemical analysis challenging Western blot analysis as validation step for antibodies intended for ELISA and immunohistochemistry

Zhang, Y.; Zhang, W.; Yang, M.; zhang, j.

10.1101/2022.02.14.480459 — biochemistry — Posted on 2022-02-15

1676 Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments

Lavenus, S. B.; Vosatka, K. W.; Caruso, A. P.; Ullo, M. F.; Khan, A.; Logue, J. S.

10.1101/2020.06.15.153007 — cell biology — Posted on 2022-02-15

1677 Bioassay evaluation, GC-MS Analysis and Acute Toxicity Assessment of Methanolic Extracts of Trichoderma species in an Animal Model

Mulatu, A.; Megersa, N.; Tolcha, T.; Alemu, T.; Vetukuri, R. R.

10.1101/2022.02.15.480498 — microbiology — Posted on 2022-02-15

1678 An estimation of the absolute number of axons indicates that human cortical areas are sparsely connected

Rosen, B. Q.; Halgren, E.

10.1101/2021.06.07.447453 — neuroscience — Posted on 2022-02-15

1679 Laminar Mechanisms of Saccadic Suppression in Primate Visual Cortex

Denagamage, S.; Morton, M.; Reynolds, J.; Jadi, M.; Nandy, A.

10.1101/2021.01.09.426063 — neuroscience — Posted on 2022-02-15

1680 Active site structure of the Shigella flexneri effector OspI

Nishide, A.; Takagi, K.; Kim, M.; Mizushima, T.

10.1101/2022.02.15.480433 — biochemistry — Posted on 2022-02-15

1681 Pushing the limits of HiFi assemblies reveals centromere diversity between two Arabidopsis thaliana genomes

Rabanal, F. A.; Graeff, M.; Lanz, C.; Fritschi, K.; Llaca, V.; Lang, M.; Carbonell-Bejerano, P.; Henderson, I.; Weigel, D.

10.1101/2022.02.15.480579 — genomics — Posted on 2022-02-15

1682 Diversity begets diversity under microbial niche construction

Estrela, S.; Diaz-Colunga, J.; Vila, J. C. C.; Sanchez-Gorostiaga, A.; Sanchez, A.

10.1101/2022.02.13.480281 — ecology — Posted on 2022-02-15

1683 Early zygotic gene product Dunk interacts with anillin to regulate Myosin II during Drosophila cleavage

Chen, J.; He, B.

10.1101/2022.02.14.480462 — developmental biology — Posted on 2022-02-15

1684 Single-cell Bayesian deconvolution

Torregrosa, G.; Oriola, D.; Trivedi, V.; Garcia-Ojalvo, J.

10.1101/2022.02.13.480250 — developmental biology — Posted on 2022-02-15

1685 Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

Ogran, A.; Havkin-Solomon, T.; Becker-Herman, S.; David, K.; Shachar, I.; Dikstein, R.

10.1101/2022.02.15.480558 — molecular biology — Posted on 2022-02-15

1686 Osteocalcin binds to the GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling

Agarwal, R.; Pi, M.; Ye, R.; Smith, M. D.; Smith, J. C.; Quarles, L. D.

10.1101/2022.02.15.480526 — molecular biology — Posted on 2022-02-15

1687 Highly efficient generation of isogenic pluripotent stem cell models using prime editing

Li, H.; Busquets, O.; Verma, Y.; Syed, K. M.; Kutnowski, N.; Pangilinan, G. R.; Gilbert, L.; Bateup, H.; Rio, D. C.; Hockemeyer, D.; Soldner, F.

10.1101/2022.02.15.480601 — molecular biology — Posted on 2022-02-15

1688 RNA targeting with CRISPR-Cas13a facilitates bacteriophage genome engineering

Guan, J.; Bosch, A. O.; Mendoza, S. D.; Karambelkar, S.; Berry, J.; Bondy-Denomy, J.

10.1101/2022.02.14.480438 — microbiology — Posted on 2022-02-15

1689 Microbiota-derived aspartate drives pathogenic Enterobacteriaceae expansion in the inflamed gut

Yoo, W.; Zieba, J. K.; Shealy, N. G.; Torres, T. P.; Thomas, J. D.; Shelton, C. D.; Foegeding, N. J.; Olsan, E. E.; Byndloss, M. X.

10.1101/2022.02.14.480453 — microbiology — Posted on 2022-02-15

1690 Strong phylogenetic and ecological effects on host competency for avian influenza in Australian wild birds

Wille, M.; Lisovski, S.; Roshier, D.; Ferenczi, M.; Hoye, B. J.; Leen, T.; Warner, S.; Fouchier, R. A. M.; Hurt, A. C.; Holmes, E. C.; Klaassen, M.

10.1101/2022.02.14.480463 — microbiology — Posted on 2022-02-15

1691 Expression of fatty acid synthase genes and their role in development and arboviral infection of Aedes aegypti

Chotiwan, N.; Brito-Sierra, C. A.; Ramirez, G.; Lian, E.; Hill, C. A.; Perera, R.

10.1101/2022.02.14.480456 — microbiology — Posted on 2022-02-15

1692 Is it the same strain? Defining genomic epidemiology thresholds tailored to individual outbreaks

Duval, A.; opatowski, L.; Brisse, S.

10.1101/2022.02.15.480545 — microbiology — Posted on 2022-02-15

1693 Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

Sasaki, M.; Tabata, K.; Kishimoto, M.; Itakura, Y.; Kobayashi, H.; Ariizumi, T.; Uemura, K.; Toba, S.; Kusakabe, S.; Maruyama, Y.; Iida, S.; Nakajima, N.; Suzuki, T.; Yoshida, S.; Nobori, H.; Sanaki, T.; Kato, T.; Shishido, T.; Hall, W. W.; Orba, Y.; Sato, A.; Sawa, H.

10.1101/2022.02.14.480338 — microbiology — Posted on 2022-02-15

1694 Engineering Agrobacterium tumefaciens adhesion to target cells.

Pierrat, X.; Al-Mayyah, Z.; Persat, A.

10.1101/2022.02.15.480547 — microbiology — Posted on 2022-02-15

1695 Milk of cow and goat, immunized by recombinant protein vaccine ZF-UZ-VAC2001(Zifivax), contains neutralizing antibodies against SARS-CoV-2 and remains active after standard milk pasteurization

Garib, V.; Katsamaki, S.; Turdikulova, S. U.; Levitskaya, Y.; Zakhidova, N.; Bus, G.; Karamova, K.; Rakhmedova, M.; Magbulova, N.; Bruhov, A.; Garib, F. Y.; Abdurakhmonov, I. Y.

10.1101/2022.02.14.480298 — immunology — Posted on 2022-02-15

1696 Reduced antigenicity of Omicron lowers host serologic response

Tubiana, J.; Xiang, Y.; Fan, L.; Wolfson, H. J.; Chen, K.; Schneidman-Duhovny, D.; Shi, Y.

10.1101/2022.02.15.480546 — immunology — Posted on 2022-02-15

1697 Sympathetic blockage attenuates fasting-induced hepatic steatosis

Zheng, L.; Gong, L.; Lu, S.; Zhou, Y.; Duan, Z.; Wei, F.; Li, G.

10.1101/2022.02.13.480240 — pathology — Posted on 2022-02-15

1698 Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

Wang, L.; Chen, R.; Han, G.; Liu, X.; Huang, T.; Diao, J.; Sun, Y.

10.1101/2022.02.14.480395 — biophysics — Posted on 2022-02-15

1699 Structural model of microtubule dynamics inhibition by Kinesin-4 from the crystal structure of KLP-12 - tubulin complex

Taguchi, S.; Nakano, J.; Imasaki, T.; Kita, T.; Saijo-Hamano, Y.; Sakai, N.; Shigematsu, H.; Okuma, H.; Shimizu, T.; Nitta, E.; Kikkawa, S.; Mizobuchi, S.; Niwa, S.; Nitta, R.

10.1101/2022.02.14.480441 — biophysics — Posted on 2022-02-15

1700 The BASP1 transcriptional repressor modifies chromatin through lipid-dependent and lipid-independent mechanisms

Moorhouse, A. J.; Loats, A. E.; Medler, K. F.; Roberts, S. G. E.

10.1101/2022.02.15.480538 — biochemistry — Posted on 2022-02-15

1701 Accurate models of substrate preferences of post-translational modification enzymes from a combination of mRNA display and deep learning

Vinogradov, A. A.; Chang, J. S.; Onaka, H.; Goto, Y.; Suga, H.

10.1101/2022.02.14.480467 — biochemistry — Posted on 2022-02-15

1702 Optimization of conditions for conjugation of outer membrane vesicles of Salmonella Typhimurium with oral delivery systems using response surface method

Sultana, A.; Nath, R.; Tamuly, S.; Begum, Y.; Boruah, J. S.; Shome, A.; Chowdhury, D.; Deka, S. S.; Kalita, D. J.

10.1101/2022.02.14.480461 — biochemistry — Posted on 2022-02-15

1703 Replication-associated inversions are the dominant form of bacterial chromosome structural variation

D'Iorio, M.; Dewar, K.

10.1101/2022.02.15.480581 — genomics — Posted on 2022-02-15

1704 Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models

Mohajeri, K.; Yadav, R.; D'haene, E.; Boone, P.; Erdin, S.; Gao, D.; Moyses-Oliveir, M.; Bhavsar, R.; Currall, B.; O'Keefe, K.; Burt, N. D.; Lowther, C.; Lucente, D.; Salani, M.; Menten, B.; Tai, D. J. C.; Gusella, J. F.; Vergult, S.; Talkowski, M. E.

10.1101/2022.02.15.480098 — genomics — Posted on 2022-02-15

1705 Contribution of deep soil layers to the transpiration of a temperate deciduous forest: quantification and implications for the modelling of productivity

Maysonnave, J.; Delpierre, N.; Francois, C.; Jourdan, M.; Cornut, I.; Bazot, S.; Morfin, A.; Vincent, G.; Berveiller, D.

10.1101/2022.02.14.480025 — ecology — Posted on 2022-02-15

1706 Flower visitation of alien plants is non-linearly related to phylogenetic and floral similarity to native plants

Razanajatovo, M.; Rakoto Joseph, F.; Rajaonarivelo Andrianina, P.; van Kleunen, M.

10.1101/2022.02.14.480304 — ecology — Posted on 2022-02-15

1707 Monoacylglycerol O-acyltransferase 1 is required for adipocyte differentiation in vitro but does not affect adiposity in mice

Singer, J. M.; Shew, T. M.; Ferguson, D.; Renkemeyer, M. K.; Pietka, T. A.; Hall, A. M.; Finck, B. N.; Lutkewitte, A. J.

10.1101/2022.02.14.480414 — molecular biology — Posted on 2022-02-15

1708 A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

Dinnon, K. H.; Leist, S. R.; Okuda, K.; Dang, H.; Fritch, E. J.; Gully, K. L.; Cruz, G.; Evangelista, M. D.; Asakura, T.; Gilmore, R. C.; Hawkins, P.; Nakano, S.; West, A.; Schäfer, A.; Gralinski, L. E.; Everman, J. L.; Sajuthi, S. P.; Zweigart, M. R.; Dong, S.; McBride, J.; Cooley, M. R.; Hines, J. B.; Love, M. K.; Groshong, S. D.; VanSchoiack, A.; Phelan, S. J.; Liang, Y.; Hether, T.; Leon, M.; Zumwalt, R. E.; Barton, L. M.; Duval, E. J.; Mukhopadhyay, S.; Stroberg, E.; Borczuk, A.; Thorne, L. B.; Sakthivel, M. K.; Lee, Y. Z.; Hagood, J. S.; Mock, J. R.; Seibold, M. A.; O'Neal, W. K.; Montg

10.1101/2022.02.15.480515 — microbiology — Posted on 2022-02-15

1709 Diverse innate immune factors protect yeast from lethal viral pathogenesis

Chau, S.; Gao, J.; Diao, A.; Cao, M.; Davidson, A. R.; Meneghini, M. D.

10.1101/2022.02.14.480455 — microbiology — Posted on 2022-02-15

1710 A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

Farley, S. E.; Kyle, J.; Leier, H.; Bramer, L. M.; Weinstein, J.; Bates, T. A.; Lee, J.-Y.; Metz, T. O.; Schultz, C.; Tafesse, F.

10.1101/2022.02.14.480430 — microbiology — Posted on 2022-02-15

1711 A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

Liu, Y.; Zhang, X.; Liu, J.; Xia, H.; Zou, J.; Muruato, A. E.; Periasamy, S.; Plante, J. A.; Bopp, N. E.; Kurhade, C.; Bukreyev, A.; Ren, P.; Wang, T.; Menachery, V. D.; Plante, K. S.; Xie, X.; Weaver, S. C.; Shi, P.-Y.

10.1101/2022.02.14.480460 — microbiology — Posted on 2022-02-15

1712 ATPase activity of B. subtilis RecA affects the dynamic formation of RecA filaments at DNA double strand breaks

Hernandez-Tamayo, R.; Steube, N.; Heimerl, T.; Hochberg, G.; Graumann, P.

10.1101/2022.02.15.480544 — microbiology — Posted on 2022-02-15

1713 The interplay between sulfur metabolism and desulfurization profile in Rhodococcus: Unraveling the role of the transsulfuration pathway

Martzoukou, O.; Glekas, P.; Avgeris, M.; Mamma, D.; Scorilas, A.; Kekos, D.; Amillis, S.; Hatzinikolaou, D. G.

10.1101/2022.02.14.480474 — microbiology — Posted on 2022-02-15

1714 Strain-dependent induction of primary bile acid 7-dehydroxylation by cholic acid

Vico Oton, E.; Volet, C.; Jacquemin, N. L. M.; Meibom, K. L.; Bernier-Latmani, R.

10.1101/2022.02.15.480494 — microbiology — Posted on 2022-02-15

1715 NaCl Triggers the Sessile-to-Motile Transition of Bacillus subtilis

Murugan, P. A.; Gupta, M. K.; Sankar, T. S.; Chandran, S.; Matheshwaran, S.

10.1101/2022.02.15.480532 — microbiology — Posted on 2022-02-15

1716 Linking CFTR modulators to opportunistic bacterial infections in cystic fibrosis

Cigana, C.; Giannella, R.; Colavolpe, A.; Alcalá-Franco, B.; Mancini, G.; Colombi, F.; Bigogno, C.; Bastrup, U.; Bertoni, G.; Bragonzi, A.

10.1101/2022.02.15.478594 — microbiology — Posted on 2022-02-15

1717 The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

Van Coillie, J.; Pongracz, T.; Rahmoeller, J.; Chen, H.-J.; Geyer, C. E.; van Vught, L. A.; Buhre, J. S.; Sustic, T.; van Osch, T. L. J.; Steenhuis, M.; Hoepel, W.; Wang, W.; Lixenfeld, A.; Nouta, J.; Keijzer, S.; Linty, F.; Visser, R.; Larsen, M. D.; Martin, E. L.; Kuensting, I.; Lehrian, S.; von Kopylow, V.; Kern, C.; Lunding, H.; de Winther, M. P. J.; van Mourik, N.; Rispens, T.; Graf, T.; Slim, M. A.; Minnaar, R. P.; Bomers, M. K.; Sikkens, J. J.; Vlaar, A. P. J.; van der Schoot, E. C.; den Dunnen, J.; Ehlers, M.; Wuhrer, M.; Vidarsson, G.; Fatebenefratelli-Sacco Infectious Diseases Physic

10.1101/2022.02.14.480353 — immunology — Posted on 2022-02-15

1718 Revisiting the origin of interleukin 1 (IL-1) based on biological activities of IL-1 in anamniotes and their sub-functionalization in amniotes

Hasel de Carvalho, E.; Bartok, E.; Stoelting, H.; Bajoghli, B.; Leptin, M.

10.1101/2022.02.15.480490 — immunology — Posted on 2022-02-15

1719 Increased low-frequency brain responses to music after psilocybin therapy for depression

Wall, M. B.; Lam, C.; Ertl, N.; Kaelen, M.; Roseman, L.; Nutt, D. J.; Carhart-Harris, R. L.

10.1101/2022.02.13.480302 — neuroscience — Posted on 2022-02-15

1720 Translaminar Recurrence from Layer 5 Suppresses Superficial Cortical Layers

Onodera, K.; Kato, H. K.

10.1101/2022.02.13.480275 — neuroscience — Posted on 2022-02-15

1721 Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

Aggarwal, A.; Liu, R.; Chen, Y.; Ralowicz, A. J.; Bergerson, S. J.; Tomaska, F.; Hanson, T. L.; Hasseman, J. P.; Reep, D.; Tsegaye, G.; Yao, P.; Ji, X.; Kloos, M.; Walpita, D.; Patel, R.; Tilberg, P. W.; Mohar, B.; The GENIE Project Team, ; Looger, L.; Marvin, J.; Hoppa, M.; Konnerth, A.; Kleinfeld, D.; Schreiter, E. R.; Podgorski, K.

10.1101/2022.02.13.480251 — neuroscience — Posted on 2022-02-15

1722 Faster growth enhances low carbon fuel and chemical production through gas fermentation

Azevedo de Lima, L.; Ingelman, H.; Brahmbhatt, K.; Reinmets, K.; Barry, C.; Harris, A.; Marcellin, E.; Koepke, M.; Valgepea, K.

10.1101/2022.02.13.480257 — systems biology — Posted on 2022-02-15

1723 OsIRO3 negatively regulates Fe homeostasis by repressing the expression of OsIRO2

Li, C.; Li, Y.; Xu, P.; Liang, G.

10.1101/2022.02.14.480324 — plant biology — Posted on 2022-02-15

1724 Nitric oxide negatively regulates gibberellin signaling to coordinate growth and salt tolerance in Arabidopsis

Chen, L.; Sun, S.; Song, C.-P.; Zhou, J.-M.; Li, J.; Zuo, J.

10.1101/2022.02.13.480237 — plant biology — Posted on 2022-02-15

1725 Interpretation of southern hemisphere humpback whale diet via stable isotopes; implications of tissue-specific analysis

Eggebo, J.; Gross, J.; Bengtson Nash, S.

10.1101/2022.02.14.480312 — physiology — Posted on 2022-02-15

1726 Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer Xenografts

Wu, Y.; Konate, M. M.; Hollingshead, M.; Karim, B.; Diebold, B.; Lu, J.; Antony, S.; Meitzler, J. L.; Juhasz, A.; Jiang, G.; Dahan, I.; Roy, K.; Doroshow, J. H.

10.1101/2022.02.13.480277 — pharmacology and toxicology — Posted on 2022-02-15

1727 Designing human Sphingosine-1-phosphate lyases using a temporal Dirichlet variational autoencoder

Lobzaev, E.; Herrera, M. A.; Campopiano, D. J.; Stracquadanio, G.

10.1101/2022.02.14.480330 — bioinformatics — Posted on 2022-02-15

1728 R-based method for quantitative analysis of biofilm thickness by using Confocal Laser Scanning Microscopy

Fruehauf, H. M.; Stoeckl, M.; Holtmann, D.

10.1101/2022.02.13.480190 — bioinformatics — Posted on 2022-02-15

1729 uniPort: a unified computational framework for single-cell data integration with optimal transport

Cao, K.; Gong, Q.; Hong, Y.; Wan, L.

10.1101/2022.02.14.480323 — bioinformatics — Posted on 2022-02-15

1730 scShapes: A statistical framework for identifying distribution shapes in single-cell RNA-sequencing data

Dharmaratne, M.; Kulkarni, A. S.; Taherian Fard, A.; Mar, J. C.

10.1101/2022.02.13.480299 — bioinformatics — Posted on 2022-02-15

1731 Efficient Bayesian inference for mechanistic modelling with high-throughput data

Martina Perez, S.; Sailem, H.; Baker, R. E.

10.1101/2022.02.14.480336 — bioinformatics — Posted on 2022-02-15

1732 Experimental and analytical framework for ''mix-and-read'' assays based on split luciferase

McArthur, N.; Cruz-Teran, C.; Thatavarty, A.; Reeves, G. T.; Rao, B. M.

10.1101/2022.02.13.480265 — bioengineering — Posted on 2022-02-15

1733 Characterization of altered molecular mechanisms in Parkinson disease through cell type-resolved multi-omics analyses

Lee, A.; Kim, C.; Park, S.; Jun, K.; Eom, J.; Lee, S.-J.; Chung, S. J.; Rissman, R. A.; Chung, J.; Masliah, E.; Jung, I.

10.1101/2022.02.13.479386 — genomics — Posted on 2022-02-15

1734 Clock Work: Deconstructing the Epigenetic Clock Signals in Aging, Disease, and Reprogramming

Levine, M.; Higgins-Chen, A. T.; Thrush, K.; Minteer, C. J.; Niimi, P.

10.1101/2022.02.13.480245 — genetics — Posted on 2022-02-15

1735 Population based selection shapes the T cell receptor repertoire during thymic development

Camaglia, F.; Ryvkin, A.; Greenstein, E.; Reich-Zeliger, S.; Chain, B.; Mora, T.; Walczak, A. M.; Friedman, N.

10.1101/2022.02.14.480309 — immunology — Posted on 2022-02-15

1736 Predicting vertical ground reaction forces from 3D accelerometery using reservoir computers leads to accurate gait event detection

Bach, M. M.; Dominici, N.; Daffertshofer, A.

10.1101/2022.02.14.480318 — neuroscience — Posted on 2022-02-15

1737 Exploring volume mediated bystander-inhibition in a neuron model of the Locus coeruleus

Barai, S.; Hosseini, H.; More, K.; Braun, J.; Prigge, M.

10.1101/2022.02.13.480256 — neuroscience — Posted on 2022-02-15

1738 Salinity induces discontinuous protoxylem by a DELLA-dependent mechanism promoting salt tolerance in Arabidopsis seedlings

Augstein, F.; Carlsbecker, A.

10.1101/2022.02.13.480244 — plant biology — Posted on 2022-02-15

1739 ScanNet: An interpretable geometric deep learning model for structure-based protein binding site prediction

Tubiana, J.; Schneidman-Duhovny, D.; Wolfson, H. J.

10.1101/2021.09.05.459013 — bioinformatics — Posted on 2022-02-15

1740 BinSPreader: refine binning results for fuller MAG reconstruction

Tolstoganov, I.; Kamenev, Y.; Ochkalova, S.; Kruglikov, R.; Korobeynikov, A.

10.1101/2022.02.14.480326 — bioinformatics — Posted on 2022-02-15

1741 SARS-CoV-2 Omicron-specific mRNA vaccine induces potent and broad antibody responses in vivo

Fang, Z.; Peng, L.; Lin, Q.; Ren, P.; Suzuki, K.; Xiong, Q.; Clark, P.; Lin, C.; Chen, S.

10.1101/2022.02.14.480449 — immunology — Posted on 2022-02-15

1742 Virological characteristics of SARS-CoV-2 BA.2 variant

Yamasoba, D.; Kimura, I.; Nasser, H.; Morioka, Y.; Nao, N.; Ito, J.; Uriu, K.; Tsuda, M.; Zahradnik, J.; Shirakawa, K.; Suzuki, R.; Kishimoto, M.; Kosugi, Y.; Kobiyama, K.; Hara, T.; Toyoda, M.; Tanaka, Y. L.; Butlertanaka, E. P.; Shimizu, R.; Ito, H.; Wang, L.; Oda, Y.; Orba, Y.; Sasaki, M.; Nagata, K.; Yoshimatsu, K.; Asakura, H.; Nagashima, M.; Sadamasu, K.; Yoshimura, K.; Kuramochi, J.; Seki, M.; Fujiki, R.; Kaneda, A.; Shimada, T.; Nakada, T.-a.; Sakao, S.; Suzuki, T.; Ueno, T.; Takaori-Kondo, A.; Ishii, K. J.; Schreiber, G.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Sawa

10.1101/2022.02.14.480335 — microbiology — Posted on 2022-02-15

1743 Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

10.1101/2022.02.14.480426 — pharmacology and toxicology — Posted on 2022-02-15

1744 Introducing CARATE: Finally speaking chemistry.

Kleber, J. M.

10.1101/2022.02.12.470636 — bioinformatics — Posted on 2022-02-15

1745 A novel consensus-based computational pipeline for rapid screening of antibody therapeutics for efficacy against SARS-CoV-2 variants of concern including omicron variant

Kumar, N.; Kaushik, R.; Zhang, K. Y. J.; Uversky, V. N.; Srivastava, P.; Sahu, U.; Sood, R.; Bhatia, S.

10.1101/2022.02.11.480177 — bioinformatics — Posted on 2022-02-15

1746 A sequence-based global map of regulatory activity for deciphering human genetics

Chen, K. M.; Wong, A. K.; Troyanskaya, O. G.; Zhou, J.

10.1101/2021.07.29.454384 — genomics — Posted on 2022-02-15

1747 SARS-CoV-2-specific T cells associate with reduced lung function and inflammation in pulmonary post-acute sequalae of SARS-CoV-2

Littlefield, K.; Watson, R.; Schneider, J.; Neff, C.; Yamada, E.; Zhang, M.; Campbell, T.; Falta, M.; Jolley, S.; Fontenot, A.; Palmer, B.

10.1101/2022.02.14.480317 — immunology — Posted on 2022-02-15

1748 Increased Potency and Breadth of SARS-CoV-2 Neutralizing Antibodies After a Third mRNA Vaccine Dose

Muecksch, F.; Wang, Z.; Cho, A.; Gaebler, C.; Ben Tanfous, T.; DaSilva, J.; Bednarski, E.; Ramos, V.; Zong, S.; Johnson, B.; Raspe, R.; Schaefer-Babajew, D.; Shimeliovich, I.; Daga, M.; Yao, K.-H.; Schmidt, F.; Millard, K. G.; Turroja, M.; Jankovic, M.; Oliveira, T. Y.; Gazumyan, A.; Caskey, M.; Hatziioannou, T.; Bieniasz, P. D.; Nussenzweig, M.

10.1101/2022.02.14.480394 — immunology — Posted on 2022-02-15

1749 Omicron-Based Vaccine Candidate Elicits Potent Neutralizing Antibodies in the Animal Model

Abdoli, A.; Khanali, J.; Azangou-Khyavy, M.; Abbasi-Kangevari, M.; Ghamari, S.-H.; Malekpour, M.-R.; Jamshidi, H.; Lari Baghal, M.; Taqavian, M.; Jalili, H.

10.1101/2022.02.11.480131 — immunology — Posted on 2022-02-15

1750 Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease

Iovino, L.; Giusti, V.; Pischedda, F.; Giusto, E.; Plotegher, N.; Marte, A.; Battisti, I.; Di Iacovo, A.; Marku, A.; Piccoli, G.; Bandopadhyay, R.; Perego, C.; Bonifacino, T.; Bonanno, G.; Roseti, C.; Bossi, E.; Arrigoni, G.; Bubacco, L.; Greggio, E.; Hilfiker, S.; Civiero, L.

10.1101/2021.08.04.455053 — neuroscience — Posted on 2022-02-15

1751 Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity

Li, J.; Christian-Hinman, C. A.

10.1101/2022.02.13.480255 — neuroscience — Posted on 2022-02-15

1752 Exploring neural correlates of behavioral and academic resilience among children in poverty

Ellwood-Lowe, M. E.; Irving, C. N.; Bunge, S. A.

10.1101/2021.09.16.460710 — neuroscience — Posted on 2022-02-15

1753 Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

Zhu, X.; Huang, G.; Zeng, C.; Zhan, X.; Liang, K.; Zhao, Y.; Wang, P.; Wang, Q.; Zhou, Q.; Tao, Q.; Liu, M.; Lei, J.; Yan, C.; Shi, Y.

10.1101/2022.02.14.480321 — biophysics — Posted on 2022-02-15

1754 Mining divergent and conserved signals in 5' splicing site sequences across fungi, metazoa and plants

Beckel, M.; Kaufman, B.; Yanovsky, M.; Chernomoretz, A.

10.1101/2021.07.14.452117 — bioinformatics — Posted on 2022-02-15

1755 Rapid Knowledgebase Construction and Hypotheses Generation Using Extractive Literature Search

Launer-Wachs, S.; Taub-Tabib, H.; Goldberg, Y.; Shamay, Y.

10.1101/2022.02.13.480241 — bioinformatics — Posted on 2022-02-15

1756 SpecDB: A Relational Database for Archiving Biomolecular NMR Spectra Data

Fraga, K. J.; Huang, Y. J.; Ramelot, T. A.; Swapna, G. V. T.; Lashawn Anak Kendary, A.; Li, E.; Korf, I.; Montelione, G. T.

10.1101/2022.02.12.480212 — bioinformatics — Posted on 2022-02-15

1757 Natural tolerance to transposition is associated with double-strand break repair and germ-cell differentiation

Lama, J.; Srivasta, S.; Tasnim, S.; Hubbard, D.; Hadjipanteli, S.; Kelleher, E. S.

10.1101/2021.04.30.441852 — genomics — Posted on 2022-02-15

1758 Order of arrival promotes coexistence via spatial niche preemption by the weak competitor

Fragata, I.; Costa-Pereira, R.; Kozak, M.; Majer, A.; Godoy, O.; Magalhaes, S.

10.1101/2021.10.06.463344 — ecology — Posted on 2022-02-15

1759 Extracting abundance information from DNA-based data

Luo, M.; Ji, Y.; Warton, D.; Yu, D. W.

10.1101/2022.01.06.475221 — ecology — Posted on 2022-02-15

1760 Uncertainties of cell number estimation in cyanobacterial colonies and the potential use of sphere packing

T-Krasznai, E.; Lerf, V.; Toth, I.; Kisantal, T.; Varbiro, G.; Vasas, G.; B-Beres, V.; Gorgenyi, J.; Lukacs, A.; Kokai, Z.; Borics, G.

10.1101/2022.02.13.480236 — ecology — Posted on 2022-02-15

1761 Quantifying the economic impact of Peristenus relictus establishment on host Lygus hesperus populations in California organic strawberry

Nieto, D.; Bick, E.; Pickett, C.

10.1101/2022.02.10.480012 — ecology — Posted on 2022-02-15

1762 cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space

Lamothe-Molina, P.; Franzelin, A.; Beck, L.; Li, D.; Auksutat, L.; Fieblinger, T.; Laprell, L.; Ahlbeck, J.; Gee, C. E.; Kneussel, M.; Engel, A.; Hilgetag, C. C.; Morellini, F.; Oertner, T. G.

10.1101/2020.08.29.273391 — neuroscience — Posted on 2022-02-15

1763 KIBRA Regulates AMPA Receptor Expression, Synaptic Plasticity, and Memory in an Age-Dependent Manner

Volk, L. J.; Mendoza, M. L.; Quigley, L.; Dunham, T.

10.1101/2022.02.13.480286 — neuroscience — Posted on 2022-02-15

1764 PyZebrascope: an open-source platform for brain-wide neural activity imaging in zebrafish

Barbara, R.; Kantharaju, M. N.; Haruvi, R.; Harrington, K.; Kawashima, T.

10.1101/2022.02.13.480249 — neuroscience — Posted on 2022-02-15

1765 Insulin/IGF Signaling Regulates Presynaptic Glutamate Release in Aversive Olfactory Learning

Bargmann, C. I.; Cheng, D.; Lee, J.; Ebert, M.; Brown, M.; Tomioka, M.; Iino, Y.

10.1101/2022.02.14.480437 — neuroscience — Posted on 2022-02-15

1766 The V-type H+-ATPase is targeted in anti-diuretic hormone control of the Malpighian (renal) tubules in Aedes aegypti

Sajadi, F.; Paluzzi, J.-P. V.

10.1101/2022.02.13.480270 — physiology — Posted on 2022-02-15

1767 Acute myeloid leukemia cells are targeted by the naturally occurring CXCR4 antagonist EPI-X4

Kaiser, L. M.; Harms, M.; Sauter, D.; Rawat, V. P. S.; Glitscher, M.; Gross, R.; Hildt, E.; Muench, J.; Buske, C.

10.1101/2021.03.11.434944 — cancer biology — Posted on 2022-02-15

1768 Microsecond Melting and Revitrification of Cryo Samples - Protein Structure and Beam-Induced Motion

Harder, O. F.; Voss, J. M.; Olshin, P. K.; Drabbels, M.; Lorenz, U. J.

10.1101/2022.02.14.480378 — biophysics — Posted on 2022-02-15

1769 Dynamic S-acylation of STIM1 is required for store-operated Ca 2+ entry

Kodakandla, G.; West, S. J.; Zhu, M. X.; Wang, Q.; Tewari, R.; Akimzhanov, A. M.; Boehning, D. F.

10.1101/2022.02.15.480522 — cell biology — Posted on 2022-02-15

1770 Preclinical establishment of a divalent vaccine against SARS-CoV-2

Hevesi, Z.; Gerges, D.; Kapps, S.; Freire, R.; Schmidt, S.; Pollak, D.; Schmetterer, K.; Frey, T.; Lang, R.; Winnicki, W.; Schmidt, A.; Harkany, T.; Wagner, L.

10.1101/2022.02.10.479919 — bioengineering — Posted on 2022-02-15

1771 Neurodevelopmental Patterns of Early Postnatal White Matter Maturation Represent Distinct Underlying Microstructure and Histology

Nazeri, A.; Krsnik, Z.; Kostovic, I.; Ha, S. M.; Kopic, J.; Alexopoulos, D.; Kaplan, S.; Meyer, D.; Luby, J. L.; Warner, B. B.; Rogers, C. E.; Barch, D. M.; Shimony, J. S.; McKinstry, R. C.; Neil, J. J.; Smyser, C. D.; Sotiras, A.

10.1101/2022.02.11.480169 — neuroscience — Posted on 2022-02-15

1772 Mineralized coleoid cranial cartilage from the Late Triassic Polzberg Konservat-Lagerstätte (Austria)

Lukeneder, P.; Lukeneder, A.

10.1101/2022.02.14.480445 — paleontology — Posted on 2022-02-15

1773 Deep embeddings to comprehend and visualize microbiome protein space

Odrzywolek, K.; Karwowska, Z.; Majta, J.; Byrski, A.; Milanowska-Zabel, K.; Kosciolek, T.

10.1101/2021.07.21.452490 — bioinformatics — Posted on 2022-02-15

1774 insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology

Strawbridge, S. E.; Kurowski, A.; Corujo-Simon, E.; Fletcher, A. G.; Nichols, J.

10.1101/2021.11.15.468285 — developmental biology — Posted on 2022-02-15

1775 SMC protein RecN drives RecA filament translocation and remodelling for in vivo homology search

Chimthanawala, A.; Parmar, J. J.; Kumar, S.; Iyer, K. S.; Rao, M.; Badrinarayanan, A.

10.1101/2021.08.16.456443 — cell biology — Posted on 2022-02-15

1776 An arginase 2 promoter transgenic illuminates anti-inflammatory signalling in zebrafish

Hammond, F. R.; Lewis, A.; Anderson, H. E.; Williams, L. G.; Meijer, A. H.; Wiegertjes, G. F.; Elks, P. M.

10.1101/2022.02.14.480079 — immunology — Posted on 2022-02-15

1777 On the edge of criticality: strength-dependent perturbation unveils delicate balance between fluctuation and oscillation in brain dynamics

Perl, Y. S.; Escrichs, A.; Tagliazucchi, E.; Kringelbach, M. L.; Deco, G.

10.1101/2021.09.23.461520 — neuroscience — Posted on 2022-02-15

1778 Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

McSweeney, D.; Gabriel, R.; Jin, K.; Pang, Z. P.; Aronow, B. J.; Pak, C.

10.1101/2022.02.14.480404 — neuroscience — Posted on 2022-02-15

1779 Neural correlates of multisensory enhancement in audiovisual narrative speech perception: a fMRI investigation

Ross, L. A.; Molholm, S.; Butler, J. S.; Del Bene, V. A.; Foxe, J. J.

10.1101/2022.02.14.480408 — neuroscience — Posted on 2022-02-15

1780 Out of the blue; Phototropins of the leaf vascular bundle sheath mediate the blue light regulation of the leaf hydraulic conductance

Grunwald, Y.; Gosa, S. C.; Torne, T.; Moran, N.; Moshelion, M.

10.1101/720912 — plant biology — Posted on 2022-02-15

1781 Macromolecular crowding limits growth under pressure

Alric, B.; Formosa-Dague, C.; Dague, E.; Holt, L. J.; Delarue, M.

10.1101/2021.06.04.446859 — biophysics — Posted on 2022-02-15

1782 Generation of dynamic three-dimensional genome structure through phase separation of chromatin

Fujishiro, S.; Sasai, M.

10.1101/2021.05.06.443035 — biophysics — Posted on 2022-02-15

1783 High Resolution and Multidimensional Protein Condensate Phase Diagrams with a Combinatorial Microdroplet Platform

Arter, W. E.; Qi, R.; Erkamp, N. A.; Krainer, G.; Didi, K.; Welsh, T. J.; Acker, J.; Nixon-Abell, J.; Qamar, S.; Xu, Y.; Guillen-Boixet, J.; Franzmann, T. M.; Kuster, D.; Hyman, A. A.; Borodavka, A.; St George-Hyslop, P.; Alberti, S.; Knowles, T. P.

10.1101/2020.06.04.132308 — biophysics — Posted on 2022-02-15

1784 GlycoSHIELD: a versatile pipeline to assess glycan impact on protein structures

Gecht, M.; von Bülow, S.; Penet, C.; Hummer, G.; Hanus, C.; Sikora, M.

10.1101/2021.08.04.455134 — bioinformatics — Posted on 2022-02-15

1785 Characterisation and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry

Vanhinsbergh, C.; Criscuolo, A.; Sutton, J.; Murphy, K.; Williamson, A. J.; Cook, K.; Dickman, M. J.

10.1101/2022.02.14.480356 — biochemistry — Posted on 2022-02-15

1786 Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386

McHugh, R. E.; Munnoch, J. T.; Roe, A. J.; Hoskisson, P. A.

10.1101/2021.06.01.446637 — genomics — Posted on 2022-02-15

1787 Functional substitutability of native herbivores by livestock for long-term soil carbon sequestration depends on microbial decomposers.

Roy, S.; Bagchi, S.

10.1101/2022.02.07.479355 — ecology — Posted on 2022-02-15

1788 The calcium channel Orai1 is required for osteoblast development: studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1

Robinson, L. J.; Soboloff, J.; Tourkova, I. L.; Larrouture, Q. C.; Papachristou, D. J.; Gross, S.; Hooper, R.; Samakai, E.; Worley, P. F.; Tuckermann, J.; Witt, M. R.; Blair, H. C.

10.1101/2022.02.14.480443 — developmental biology — Posted on 2022-02-14

1789 Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in Saccharomyces cerevisiae

Girik, V.; Feng, S.; Hariri, H.; Henne, W. M.; Riezman, H.

10.1101/2021.05.04.442581 — cell biology — Posted on 2022-02-15

1790 Self-assembly of pericentriolar material in interphase cells lacking centrioles

Chen, F.; Wu, J.; Iwanski, M. K.; Jurriens, D.; Sandron, A.; Pasolli, M.; Puma, G.; Kromhout, J. Z.; Yang, C.; Nijenhuis, W.; Kapitein, L. C.; Berger, F.; Akhmanova, A.

10.1101/2021.08.22.457259 — cell biology — Posted on 2022-02-15

1791 Neural Mechanism of Hunger Gated Food-seeking and evaluating

Lee, Y.; Kim, Y. B.; Kim, K. S.; Song, H. Y.; Jang, M.; Ha, D.-S.; Park, J. S.; Jung, S.-H.; Lee, J.; Kim, K. M.; Cheon, D.-H.; Baek, I.; Shin, M.-G.; Lee, E. J.; Kim, S. J.; Choi, H. J.

10.1101/2020.10.23.352187 — neuroscience — Posted on 2022-02-15

1792 Acai (Euterpe oleracea Mart) modulates oxidative stress and inflammation by NF-κB inactivation and Nrf2 up-regulation in experimental diabetes

Lima, D. Y.; Rodrigues, A.; Mouro, M.; Seif, E.; Punaro, G.; Higa, E.

10.1101/2022.02.14.480447 — molecular biology — Posted on 2022-02-14

1793 Functional characterization of a neuropeptide receptor exogenously expressed in Aplysia neurons

Zhang, G.; Guo, S.-Q.; Yin, S.-Y.; Yuan, W.-D.; Chen, P.; Kim, J.-I.; Wang, H.-Y.; Zhou, H.-B.; Susswein, A. J.; Kaang, B.-K.; Jing, J.

10.1101/2022.02.14.480444 — neuroscience — Posted on 2022-02-14

1794 Climate Change Impacts on Broussenetia papyrifera Pollens - Metabolome Investigations and Prospects of Allergy Prevalence

Humayun, M.; Naseem, S.; Goodman, R. E.; Ali, Z.

10.1101/2022.02.14.480393 — scientific communication and education — Posted on 2022-02-14

1795 Polycystins are upregulated in fibrotic kidneys and promote renal fibrosis

Wu, M.; Wang, Y.; Jing, Y.; Chen, D.; Lin, J.; Yuan, M.; Tan, B.; Huang, D.; Ye, C.

10.1101/2021.11.03.467035 — pathology — Posted on 2022-02-14

1796 GenomicSuperSignature: interpretation of RNA-seq experiments through robust, efficient comparison to public databases

Oh, S.; Geistlinger, L.; Ramos, M.; Blankenberg, D.; van den Beek, M.; Taroni, J. N.; Carey, V. J.; Greene, C. S.; Waldron, L.; Davis, S. R.

10.1101/2021.05.26.445900 — bioinformatics — Posted on 2022-02-14

1797 Genome assembly of the numbat (Myrmecobius fasciatus), the only termitivorous marsupial

Peel, E.; Silver, L.; Brandies, P.; Hayakawa, T.; Belov, K.; Hogg, C. J.

10.1101/2022.02.13.480287 — genomics — Posted on 2022-02-14

1798 Constitutively active STAT5b feminizes mouse liver gene expression

Lau-Corona, D.; Ma, H.; Vergato, C.; Sarmento-Cabral, A.; del Rio-Moreno, M.; Kineman, R. D.; Waxman, D. J.

10.1101/2022.02.14.480424 — genomics — Posted on 2022-02-14

1799 Genomic profiling of HIV-1 integration in microglia links viral insertions to TAD organization

Rheinberger, M.; Costa, A. L.; Kampmann, M.; Glavas, D.; Shytaj, I. L.; Penzo, C.; Tibroni, N.; Fackler, O.; Vlahovicek, K.; Lucic, B.; Herrmann, C.; Lusic, M.

10.1101/2022.02.14.480322 — genomics — Posted on 2022-02-14

1800 Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP

Manakov, S. A.; Shishkin, A. A.; Yee, B. A.; Shen, K. A.; Cox, D. C.; Park, S. S.; Foster, H. M.; Chapman, K. B.; Yeo, G. W.; Van Nostrand, E. L.

10.1101/2022.02.13.480296 — genomics — Posted on 2022-02-14

1801 Complex Mutation Profiles in Mismatch Repair and Ribonucleotide Reductase Mutations Reveal Novel Repair Substrate Specificity of MutS Homolog (MSH) Complexes

Lamb, N. A.; Bard, J.; Loll-Krippleber, R.; Brown, G. W.; Surtees, J. A.

10.1101/2021.06.30.450577 — genetics — Posted on 2022-02-14

1802 TiDeTree: A Bayesian phylogenetic framework to estimate single-cell trees and population dynamic parameters from genetic lineage tracing data

Seidel, S.; Stadler, T.

10.1101/2022.02.14.480422 — developmental biology — Posted on 2022-02-14

1803 Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets

Boekell, K. L.; Brown, B. J.; Talbot, B. E.; Schlondorff, J. S.

10.1101/2022.02.01.478727 — cell biology — Posted on 2022-02-14

1804 Single extracellular vesicle analysis in human amniotic fluid shows evidence of phenotype alterations in preeclampsia

Gebara, N.; Scheel, J.; Skovronova, R.; Grange, C.; Marozio, L.; Gupta, S.; Giorgione, V.; Caicci, F.; Benedetto, C.; Khalil, A.; Bussolati, B.

10.1101/2022.02.14.480331 — molecular biology — Posted on 2022-02-14

1805 Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts

Suryawanshi, H.; Yang, H.; Lubetzky, M.; Morozov, P.; Lagman, M.; Alonso, A.; Li, C.; Snopkowski, C.; Mueller, F.; Lee, J.; Dadhania, D.; Salvatore, S.; Seshan, S.; Sharma, V.; Suthanthiran, M.; Tuschl, T.; Muthukumar, T.

10.1101/2020.09.03.281733 — molecular biology — Posted on 2022-02-14

1806 Controls on the isotopic composition of microbial methane

Gropp, J.; Jin, Q.; Halevy, I.

10.1101/2021.09.14.460204 — microbiology — Posted on 2022-02-14

1807 STING1 activation in brain endothelium by Plasmodium-sequestered heme leads to lethal cerebral malaria through activation of type I IFN response.

Pais, T. F.; Ali, H.; Silva, J. M. d.; Duarte, N.; Neres, R.; Chhatbar, C.; Acurcio, R. C.; Guedes, R. C.; Moraes, M. C. S.; Costa-Silva, B.; Ulrich, K.; Penha-Goncalves, C.

10.1101/2022.02.14.480268 — immunology — Posted on 2022-02-14

1808 The chemokine receptor CXCR3 promotes CD8+ T cell-dependent lung pathology during influenza pathogenesis

Guo, K.; Yombo, D. J. K.; Xu, J.; Wang, Z.; Schmit, T.; Tripathi, J.; Hur, J.; Sun, J.; Olszewski, M. A.; Khan, N.

10.1101/2022.02.14.480379 — immunology — Posted on 2022-02-14

1809 Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains

Zhu, B.; Park, J.-M.; Coffey, S.; Hsu, I.-U.; Lam, T. T.; Gopal, P. P.; Ginsberg, S. D.; Wang, J.; Su, C.; Zhao, H.; Hafler, D. A.; Chandra, S.; Zhang, L.

10.1101/2022.02.14.480397 — neuroscience — Posted on 2022-02-14

1810 AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

Ghosh, P.; Campos, V. J.; Vo, D. T.; Guccione, C.; Goheen-Holland, V.; Tindle, C.; Mazzini, G. S.; He, Y.; Alexandrov, L.; Lippman, S. M.; Gurski, R.; Das, S.; Curtius, K.; Yadlapati, R.; Sahoo, D.

10.1101/2022.01.30.478408 — cancer biology — Posted on 2022-02-14

1811 Architecture and self-assembly of the jumbo bacteriophage nuclear shell

Laughlin, T. G.; Deep, A.; Prichard, A. M.; Seitz, C.; Gu, Y.; Enustun, E.; Suslov, S.; Khanna, K.; Birkholz, E. A.; Armbruster, E.; McCammon, J. A.; Amaro, R. E.; Pogliano, J.; Corbett, K. D.; Villa, E.

10.1101/2022.02.14.480162 — biophysics — Posted on 2022-02-14

1812 Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure

Stelzl, L. S.; Pietrek, L. M.; Holla, A.; Oroz, J. S.; Sikora, M.; Köfinger, J.; Schuler, B.; Zweckstetter, M.; Hummer, G.

10.1101/2021.11.23.469691 — biophysics — Posted on 2022-02-14

1813 High Resolution and Multidimensional Protein Condensate Phase Diagrams with a Combinatorial Microdroplet Platform

10.1101/2020.06.04.132308 — biophysics — Posted on 2022-02-14

1814 Probabilistic modeling of ambient noise in single-cell omics data

Sheng, C.; Lopes, R.; Li, G.; Schuierer, S.; Waldt, A.; Cuttat, R.; Dimitrieva, S.; Kauffmann, A.; Durand, E.; Galli, G. G.; Roma, G.; de Weck, A.

10.1101/2022.01.14.476312 — bioinformatics — Posted on 2022-02-14

1815 Genome Enrichment of Rare, Unknown Species from Complicated Microbiome by Nanopore Selective Sequencing

Xia, Y.; SUN, Y.; Li, X.; Yang, Q.; Zhao, B.; Wu, Z.

10.1101/2022.02.13.480078 — bioinformatics — Posted on 2022-02-14

1816 Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster

Chen, D. S.; Clark, A. G.; Wolfner, M. F.

10.1101/2022.02.14.480434 — evolutionary biology — Posted on 2022-02-14

1817 Nitric oxide signaling controls collective contractions in a colonial choanoflagellate

Reyes-Rivera, J.; Wu, Y.; Guthrie, B. G. H.; Marletta, M. A.; King, N.; Brunet, T.

10.1101/2022.02.14.480389 — evolutionary biology — Posted on 2022-02-14

1818 Quantitative fate mapping: Reconstructing progenitor field dynamics via retrospective lineage barcoding

Fang, W.; Bell, C. M.; Sapirstein, A.; Asami, S.; Leeper, K.; Zack, D. J.; Ji, H.; Kalhor, R.

10.1101/2022.02.13.480215 — developmental biology — Posted on 2022-02-14

1819 DetecDiv, a deep-learning platform for automated cell division tracking and replicative lifespan analysis

Aspert, T.; Hentsch, D.; Charvin, G.

10.1101/2021.10.05.463175 — cell biology — Posted on 2022-02-14

1820 Inference of long-range cell-cell mechanical communication from ECM remodeling fluctuations

Nahum, A.; Koren, Y.; Ergaz, B.; Natan, S.; Goren, S.; Kolel, A.; Jagadeeshan, S.; Elkabets, M.; Lesman, A.; Zaritsky, A.

10.1101/2020.07.30.223149 — cell biology — Posted on 2022-02-14

1821 Structure and mechanism of the tripartite ATP-independent periplasmic (TRAP) transporter

Davies, J.; Currie, M. J.; North, R. A.; Wright, J. D.; Scalise, M.; Copping, J.; Remus, D.; Gulati, A.; Morado, D. R.; Jamieson, S. A.; Abeysekera, G. S.; Subramanian, R.; Friemann, R.; Wakatsuki, S.; Allison, J. R.; Indiveri, C.; Drew, D.; Mace, P. D.; Dobson, R.

10.1101/2022.02.13.480285 — molecular biology — Posted on 2022-02-14

1822 Comparative miRNA Transcriptomics of Mouse and Macaque Reveals Cytoskeleton is An Inhibitor for C. neoformans Invasion into Brain

Li, H.; Han, X.; Du, W.; Meng, Y.; Li, Y.; Sun, T.; Liang, Q.; Li, C.; Suo, C.; Gao, X.; Qiu, Y.; Tian, W.; An, M.; Zhang, H.; Fu, Y.; Li, X.; Lan, T.; Yang, S.; Zhang, Z.; Geng, W.; Ding, C.; Shang, H.

10.1101/2022.02.14.480319 — microbiology — Posted on 2022-02-14

1823 Saccharibacteria harness light energy using Type-1 rhodopsins that may rely on retinal sourced from microbial hosts

Jaffe, A. L.; Konno, M.; Kawasaki, Y.; Kataoka, C.; Beja, O.; Kandori, H.; Inoue, K.; Banfield, J.

10.1101/2022.02.13.480300 — microbiology — Posted on 2022-02-14

1824 Intercontinental movement of H5 2.3.4.4 Highly Pathogenic Avian Influenza A(H5N1) to the United States, 2021

Bevins, S. N.; Shriner, S. A.; Cumbee, J. C.; Dilione, K. E.; Douglass, K. E.; Ellis, J. W.; Killian, M. L.; Torchetti, M. K.; Lenoch, J. B.

10.1101/2022.02.11.479922 — microbiology — Posted on 2022-02-14

1825 Variation in Plasmodium falciparum sexual commitment rates and responses to environmental modification

Stewart, L. B.; Freville, A.; Voss, T. S.; Baker, D. A.; Awandare, G. A.; Conway, D. J.

10.1101/2022.02.14.480314 — microbiology — Posted on 2022-02-14

1826 The Transcription Factor Bach2 Negatively Regulates Natural Killer Cell Maturation and Function

Li, S.; Bern, M.; Miao, B.; Inoue, T.; Piersma, S. J.; Colonna, M.; Kurosaki, T.; Yokoyama, W. M.

10.1101/2022.02.14.480364 — immunology — Posted on 2022-02-14

1827 A Diversity Outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

HACKETT, J. B.; Glassbrook, J. E.; Muniz, M. C.; Bross, M.; Fielder, A.; Dyson, G.; McCasland, J.; Movahhedin, N.; McCarthy-Leo, C. E.; Gibson, H. M.

10.1101/2021.10.07.463570 — immunology — Posted on 2022-02-14

1828 Bile Acid Restrained T Cell Activation Explains Cholestasis Aggravated Hepatitis B Virus Infection

Ding, C.; Hong, Y.; Che, Y.; He, T.; Wang, Y.; Zhang, S.; Wu, J.; Xu, W.; Hou, J.; Cao, L.; Hao, H.

10.1101/2022.02.14.480376 — immunology — Posted on 2022-02-14

1829 An arginase 2 promoter transgenic illuminates anti-inflammatory signalling in zebrafish

Hammond, F. R.; Lewis, A.; Anderson, H. E.; Williams, L. G.; Meijer, A. H.; Wiegertjes, G. F.; Elks, P. M.

10.1101/2022.02.14.480079 — immunology — Posted on 2022-02-14

1830 Genetic load in incomplete lupus erythematosus

Slief, M.; Kheir, J.; Smith, M.; Mowery, C.; Macwana, S.; DeJager, W.; Wagner, C. A.; Aberle, T.; James, J. A.; Guthridge, J. M.

10.1101/2022.02.14.480411 — immunology — Posted on 2022-02-14

1831 Arid5a mediates an IL-17-dependent pathway that drives autoimmunity but not antifungal host defense

Taylor, T. C.; Li, Y.; Li, D.-d.; Majumder, S.; McGeachy, M. J.; Biswas, P. S.; Gingras, S.; Gaffen, S.

10.1101/2022.02.14.480386 — immunology — Posted on 2022-02-14

1832 Diversified physiological sensory input connectivity questions the existence of distinct classes of spinal interneurons in the adult cat in vivo

Kohler, M.; Bengtsson, F.; Stratmann, P.; Roehrbein, F.; Knoll, A.; Albu-Schaeffer, A.; Joerntell, H.

10.1101/2021.07.16.452238 — neuroscience — Posted on 2022-02-14

1833 Reading instruction causes changes in category-selective visual cortex

Yeatman, J. D.; Caffarra, S.; Clark, M.; Ender, S. M.; Gijbels, L.; Joo, S. J.; Kubota, E. C.; Kuhl, P. K.; Larson, E.; McCloy, D. R.; O'Brien, G.; Peterson, E. R.; Takada, M. E.; Taulu, S.

10.1101/2022.02.02.477919 — neuroscience — Posted on 2022-02-14

1834 Systematically quantifying morphological features reveals constraints on organoid phenotypes

Beck, L. E.; Lee, J.; Cote, C.; Dunagin, M. C.; Lukonin, I.; Salla, N.; Chang, M. K.; Hughes, A. J.; Mornin, J. D.; Gartner, Z. J.; Liberali, P.; Raj, A.

10.1101/2021.01.08.425947 — systems biology — Posted on 2022-02-14

1835 A de novo matrix for macroscopic living materials from bacteria

Molinari, S.; Tesoriero, R. F.; Li, D.; Sridhar, S.; Cai, R.; Soman, J.; Ryan, K. R.; Ashby, P. D.; Ajo-Franklin, C.

10.1101/2021.11.12.468079 — synthetic biology — Posted on 2022-02-14

1836 Protein undernutrition reduces the efficacy of praziquantel in a murine model of Schistosoma mansoni infection

Kadji Fassi, J. B.; Boukeng Jatsa, H.; Membe Femoe, U.; Greigert, V.; Brunet, J.; Cannet, C.; Kenfack, C. M.; Gipwe Feussom, N.; Tienga Nkondo, E.; Abou-Bacar, A.; Pfaff, A. W.; Kamgang, R.; Kamtchouing, P.; Tchuem Tchuente, L.-A.

10.1101/2022.02.14.480315 — pathology — Posted on 2022-02-14

1837 Extracellular Matrix Levels Modulate Outgrowths Dynamics in Ovarian Cancer.

Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.

10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-02-14

1838 Kinase Suppressor of Ras 2 regulates small-cell lung carcinoma tumor propagating cells

Huisman, D. H.; Frodyma, D. E.; Svoboda, R. A.; Vieira, H. M.; Chatterjee, D.; Skupa, S.; Askew, J. W.; Fisher, K. W.; Kareta, M.; Oliver, T. G.; Lewis, R. E.

10.1101/2022.02.11.480157 — cancer biology — Posted on 2022-02-14

1839 Development of methylation-based biomarkers for breast cancer detection by model training and validation in synthetic cell-free DNA

de Proce, S. M.; Adamowicz, M.; Dutta, P.; Warlow, S. J.; Moss, J.; Shemer, R.; Dor, Y.; Robert, C.; Aitman, T. J.

10.1101/2022.02.11.480085 — cancer biology — Posted on 2022-02-14

1840 The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution

Nirmal, A. J.; Maliga, Z.; Vallius, T.; Quattrochi, B.; Chen, A. A.; Jacobson, C. A.; Pelletier, R. J.; Yapp, C.; Arias-Camison, R.; Chen, Y.-A.; Lian, C. G.; Murphy, G. F.; Santagata, S.; Sorger, P. K.

10.1101/2021.05.23.445310 — cancer biology — Posted on 2022-02-14

1841 Emerging Accessibility Patterns in Long Telomeric Overhangs

Shiekh, S.; Mustafa, G.; Kodikara, S. G.; Hoque, M. E.; Yokie, E.; Portman, J. J.; Balci, H.

10.1101/2021.11.24.469879 — biophysics — Posted on 2022-02-14

1842 Bayesian Additive Regression Trees for Genotype by Environment Interaction Models

Sarti, D. A.; Prado, E. B.; Inglis, A.; dos Santos, A. A. L.; Hurley, C.; Moral, R. d. A.; Parnell, A.

10.1101/2021.05.07.442731 — bioinformatics — Posted on 2022-02-14

1843 Characterisation and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry

Vanhinsbergh, C.; Criscuolo, A.; Sutton, J.; Murphy, K.; Williamson, A. J.; Cook, K.; Dickman, M. J.

10.1101/2022.02.14.480356 — biochemistry — Posted on 2022-02-14

1844 The impact of the soluble protein fraction and kernel hardness on wheat flour starch digestibility

Wu, J.; Warren, F. J.

10.1101/2022.02.14.480385 — biochemistry — Posted on 2022-02-14

1845 Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

Swendeman, S.; Lin, D.; Guo, S.; Culbertson, A.; Kuo, A.; Levesque, M.; Cartier, A.; Seno, T.; Schmaier, A.; Galvani, S.; Inoue, A.; Parikh, S.; FitzGerald, G. A.; Liao, M.; Flaumenhaft, R.; Hla, T.

10.1101/2022.02.14.480375 — biochemistry — Posted on 2022-02-14

1846 Oligodendrocyte origin and development in the zebrafish visual system

Santos-Ledo, A.; Montes-Perez, C.; DeOliveira-Mello, L.; Arevalo, R.; Velasco, A.

10.1101/2022.02.14.480410 — developmental biology — Posted on 2022-02-14

1847 DE-NOVO HEMATOPOIESIS FROM THE FETAL LUNG

Yeung, A. K.; Villacorta-Martin, C.; Lindstrom-Vautrin, J.; Belkina, A. C.; Vanuytsel, K.; Dowrey, T. W.; Ysasi, A. B.; Vrbanac, V.; Mostoslavsky, G.; Balazs, A. B.; Murphy, G. J.

10.1101/2022.02.14.480402 — developmental biology — Posted on 2022-02-14

1848 Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

Ayloo, S.; Lazo, C. G.; Sun, S.; Zhang, W.; Cui, B.; Gu, C.

10.1101/2021.04.22.441019 — cell biology — Posted on 2022-02-14

1849 Omicron Spike protein has a positive electrostatic surface that promotes ACE2 recognition and antibody escape

Gan, H. H.; Zinno, J.; Piano, F.; Gunsalus, K.

10.1101/2022.02.13.480261 — molecular biology — Posted on 2022-02-14

1850 Vector competence and transcriptional response of Aedes aegypti for Ebinur Lake virus, a newly mosquito-borne orthobunyavirus

Yang, C.; Wang, F.; Huang, D.; Ma, H.; Zhao, L.; Zhang, G.; Li, H.; Han, Q.; Bente, D.; Yuan, Z.; Xia, H.

10.1101/2022.02.14.480372 — molecular biology — Posted on 2022-02-14

1851 Biosynthesis of aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis

McHugh, R. E.; Munnoch, J. T.; Braes, R. E.; McKean, I. J. W.; Giard, J. M.; Taladriz-Sender, A.; Peschke, F.; Burley, G. A.; Roe, A. J. A.; Hoskisson, P. A.

10.1101/2022.02.14.480342 — microbiology — Posted on 2022-02-14

1852 SARS-CoV-2 Permissive Glioblastoma Cell Line for High Throughput Antiviral Screening

Vanhulle, E.; Stroobants, J.; Provinciael, B.; Camps, A.; Noppen, S.; Maes, P.; Vermeire, K.

10.1101/2022.02.13.480238 — microbiology — Posted on 2022-02-14

1853 A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

Hayward, J. A.; Makota, F. V.; Cihalova, D.; Rajendran, E.; Zwahlen, S. M.; Shuttleworth, L.; Wiedemann, U.; Spry, C.; Saliba, K. J.; Maier, A. G.; van Dooren, G. G.

10.1101/2022.02.13.480284 — microbiology — Posted on 2022-02-14

1854 Identification of a novel interaction between Theileria Prohibitin (TaPHB-1) and bovine RUVBL-1

Araveti, P. B.; Kar, P. P.; Kuriakose, A.; Sanju, A.; Srivastava, A.

10.1101/2022.02.14.480320 — microbiology — Posted on 2022-02-14

1855 Pilotins are mobile T3SS components involved in assembly and substrate specificity of the bacterial type III secretion system

Wimmi, S.; Fleck, M.; Helbig, C.; Brianceau, C.; Langenfeld, K.; Szymanski, W.; Angelidou, G.; Glatter, T.; Diepold, A.

10.1101/2022.02.14.480308 — microbiology — Posted on 2022-02-14

1856 Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis progression across successive stages

Cheng, M.; Zhao, Y.; Cui, Y.; Zha, Y.; Li, S.; Cao, G.; Li, M.; Han, J.; Ning, K.

10.1101/2022.02.13.480248 — microbiology — Posted on 2022-02-14

1857 Mobile element integration reveals a chromosome dimer resolution system in Legionellales.

Nicholson, B.; Deecker, S. R.; Ensminger, A. W.

10.1101/2021.09.12.459815 — microbiology — Posted on 2022-02-14

1858 Next-generation intranasal Covid-19 vaccine: a polymersome-based protein subunit formulation that provides robust protection against multiple variants of concern and early reduction in viral load of the upper airway in the golden Syrian hamster model

Lam, J. H.; Shivhare, D.; Chia, T. W.; Chew, S. L.; Sinsinbar, G.; Aw, T. Y.; Wong, S.; Venkataraman, S.; Lim, F. W. I.; Vandepapeliere, P.; Nallani, M.

10.1101/2022.02.12.480188 — immunology — Posted on 2022-02-14

1859 Distinct upper airway epithelium interferon-stimulated and profibrotic gene expression between adult and infant rhesus macaques infected with SARS-CoV-2

Langel, S. N.; Garrido, C.; Phan, C.; Travieso, T.; DeMarco, T.; Ma, Z.-M.; Reader, J. R.; Olstad, K. J.; Sammak, R. L.; Shaan Lakshmanappa, Y.; Roh, J. W.; Watanabe, J.; Usachenko, J.; Immareddy, R.; Pollard, R. E.; Iyer, S. S.; Permar, S. R.; Miller, L.; Van Rompay, K. K. A.; Blasi, M.

10.1101/2022.02.12.480218 — immunology — Posted on 2022-02-14

1860 Remodeling of human colon plasma cell repertoire in ulcerative colitis

Scheid, J. F.; Eraslan, B.; Hudak, A.; Brown, E.; Sergio, D.; Delorey, T. M.; Phillips, D.; Lefkovith, A.; Jess, A. T.; Duck, L. W.; Elson, C. O.; Vlamakis, H.; Deguine, J.; Ananthakrishnan, A. A.; Graham, D. B.; Regev, A.; Xavier, R. J.

10.1101/2022.02.14.480403 — immunology — Posted on 2022-02-14

1861 Increased prevalence of a frontoparietal brain state is associated with better motor recovery in individuals with pontine stroke affecting dominant-hand corticospinal tract

Olafson, E.; Russello, G.; Jamison, K. W.; Liu, H.; Wang, D.; Bruss, J.; Boes, A.; Kuceyeski, A.

10.1101/2022.02.10.479962 — neuroscience — Posted on 2022-02-14

1862 Improving Sensitivity to Functional Responses without a Loss of Spatiotemporal Precision in Human Brain Imaging

Dowdle, L. T.; Vizioli, L.; Moeller, S.; Olman, C.; Ghose, G. M.; Yacoub, E.; Ugurbil, K.

10.1101/2021.08.26.457833 — neuroscience — Posted on 2022-02-14

1863 Molecular dynamics simulations of the Spike trimeric ectodomain of the SARS-CoV-2 Omicron variant: structural relationships with infectivity, evasion to immune system and transmissibility

Amorim, V. M. d. F.; de Souza, R. F.; Souza, A. S. d.; Guzzo, C. R.

10.1101/2022.02.14.480347 — biophysics — Posted on 2022-02-14

1864 The Yeast Lifespan Machine: a microfluidic platform for automated replicative lifespan measurements

Thayer, N. H.; Robles, M.; Xu, J.; Schinski, E. L.; Hotz, M.; Keyser, R.; Millett-Sikking, A.; Okreglak, V.; Rogers, J. V.; Waite, A. J.; Wranik, B. J.; York, A. G.; McIsaac, R. S.; Gottschling, D. E.

10.1101/2022.02.14.480146 — cell biology — Posted on 2022-02-14

1865 Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms

Kelkar, M.; Bohec, P.; Smith, M.; Sreenivasan, V.; Lisica, A.; Valon, L.; Ferber, E.; Baum, B.; Salbreux, G.; Charras, G.

10.1101/2022.02.13.480269 — cell biology — Posted on 2022-02-14

1866 Functional diversity and evolution of the Drosophila sperm proteome

Garlovsky, M. D.; Sandler, J. A.; Karr, T. L.

10.1101/2022.02.14.480191 — cell biology — Posted on 2022-02-14

1867 SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

Ikenaka, A.; Kitagawa, Y.; Yoshida, M.; Lin, C.-Y.; Niwa, A.; Nakahata, T.; Saito, M. K.

10.1101/2022.02.13.480288 — cell biology — Posted on 2022-02-14

1868 Syncollin secreted by activated human neutrophils targets bacteria

Waters, R. A.; Robinson, J.; Edwardson, J. M.

10.1101/2022.02.14.480106 — cell biology — Posted on 2022-02-14

1869 RABL2 Regulates Ciliation via Controlling IFT-B1 Basal Body Recruitment and ARL3-mediated BBSome Ciliary Retrieval

Zhang, R.-K.; Liu, Y.-X.; Sun, W.-Y.; Bao, D.-X.; Jia, R.-Q.; Zhang, C.; Fan, Z.-C.

10.1101/2022.02.13.480273 — cell biology — Posted on 2022-02-14

1870 The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

Fuchs, E.; Hurwitz, B.; Guzzi, N.; Gola, A.; Fiore, V. F.; Sendoel, A.; Nikolova, M.; Barrows, D.; Carroll, T. S.; Pasolli, H. A.

10.1101/2022.02.13.480280 — cell biology — Posted on 2022-02-14

1871 Probing protein ubiquitination in live cells

Qin, W.; Steinek, C.; Kolobynina, K.; Cardoso, M. C.; Leonhardt, H.

10.1101/2022.02.13.480252 — cell biology — Posted on 2022-02-14

1872 Daam1 negatively regulates USP10 activity

Phillips, A. T.; Boumil, E. F.; Venkatesan, A.; Castro, N.; Bernstein, A. M.

10.1101/2022.02.14.480271 — cell biology — Posted on 2022-02-14

1873 Optical Control of Membrane Fluidity Modulates Protein Secretion

Jimenez-Rojo, N.; Feng, S.; Morstein, J.; Pritzl, S. D.; Harayama, T.; Asaro, A.; Veprek, N. A.; Arp, C. J.; Reynders, M.; Novak, A. J. E.; Kanshin, E.; Ueberheide, B.; Lohmuller, T.; Riezman, H.; Trauner, D.

10.1101/2022.02.14.480333 — cell biology — Posted on 2022-02-14

1874 Got Milk? Maternal immune activation during the mid-lactational period affects nutritional milk quality and adolescent offspring sensory processing in male and female rats

DeRosa, H.; Tran, H.; Kentner, A. C.

10.1101/2022.01.03.474857 — neuroscience — Posted on 2022-02-14

1875 deCS: A tool for systematic cell type annotations of single-cell RNA sequencing data among human tissues

Pei, G.; Yan, F.; Simon, L. M.; Dai, Y.; Jia, P.; Zhao, Z.

10.1101/2021.09.19.460993 — bioinformatics — Posted on 2022-02-14

1876 Preclinical establishment of a divalent vaccine against SARS-CoV-2

Wagner, L.; Hevesi, Z.; Harkany, T.; Gerges, D.; Schmetterer, K.; Pollak, D.; Frey, T.; Lang, R.; Freire, R.; Kapps, S.; Schmidt, S.; Schmidt, A.; Winnicki, W.

10.1101/2022.02.10.479919 — bioengineering — Posted on 2022-02-14

1877 Flavobacterium johnsoniae Tyrosine Ammonia Lyase (FjTAL) in-silico Structure Prediction and Molecular Docking to L-Tyrosine, p-Coumaric Acid (pHCA) and Caffeic Acid

Mousavi Majd, S.

10.1101/2022.02.09.479702 — biochemistry — Posted on 2022-02-14

1878 The role of metal binding in the function of the human salivary antimicrobial peptide histatin-5

Stewart, L.; Hong, Y.; Holmes, I.; Firth, S.; Bolton, J.; Santos, Y.; Cobb, S.; Jakubovics, N.; Djoko, K.

10.1101/2022.01.07.472205 — microbiology — Posted on 2022-02-14

1879 The RAG1 Ubiquitin Ligase Domain Enhances Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

Burn, T.; Miot, C.; Gordon, S.; Culberson, E.; Diamond, T.; Kreiger, P.; Hayer, K.; Bhattacharyya, A.; Jones, J.; Bassing, C.; Behrens, E.

10.1101/2021.01.04.425211 — immunology — Posted on 2022-02-14

1880 Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase 1 promote oligodendrocyte development and myelination

Pan, L.; Trimarco, A.; Zhang, A. J.; Fujimori, K.; Urade, Y.; Sun, L. O.; Taveggia, C.; Zhang, Y.

10.1101/2022.02.14.480339 — neuroscience — Posted on 2022-02-14

1881 Probabilistically Weighted Multilayer Networks disclose the link between default mode network instability and psychosis-like experiences in healthy adults

Di Plinio, S.; Ebisch, S. J.

10.1101/2021.05.17.444398 — neuroscience — Posted on 2022-02-14

1882 Analysis and extension of exact mean-field theory with dynamic synaptic currents

Ruffini, G.

10.1101/2021.09.01.458563 — neuroscience — Posted on 2022-02-14

1883 Lack of evidence for participation of TMEM150c/TENTONIN3 in sensory mechanotransduction.

Ojedo-Alonso, J.; Begay, V.; Contreras, J. A. G.; Campos-Perez, A. F.; Purfuerst, B.; Lewin, G. R.

10.1101/2022.02.13.478866 — neuroscience — Posted on 2022-02-14

1884 Trehalose increases tomato drought tolerance, induces defenses, and increases resistance to bacterial wilt disease

MacIntyre, A. M.; Meline, V.; Gorman, Z.; Augustine, S. P.; Dye, C. J.; Hamilton, C. D.; Iyer-Pascuzzi, A. S.; Kolomiets, M. V.; McCulloh, K. A.; Allen, C.

10.1101/2021.07.26.453814 — plant biology — Posted on 2022-02-14

1885 Ultrahigh-throughput directed evolution of a metal-free α/β-hydrolase with a Cys-His-Asp triad into an efficient phosphotriesterase

Schnettler Fernandez, D.; Klein, O. J.; Kaminski, T. S.; Colin, P.-Y.; Hollfelder, F.

10.1101/2022.02.14.480337 — biochemistry — Posted on 2022-02-14

1886 Detection and characterization of replication origins defined by DNA polymerase epsilon

Jaksik, R.; Wheeler, D. A.; Kimmel, M.

10.1101/2021.07.27.453931 — genomics — Posted on 2022-02-14

1887 Examining the effect of chronic intranasal oxytocin administration on the neuroanatomy and behavior of three autism-related mouse models

Lindenmaier, Z.; Ellegood, J.; Stuive, M.; Easson, K.; Yee, Y.; Fernandes, D. J.; Foster, J.; Anagnostou, E.; Lerch, J. P.

10.1101/2021.01.13.426562 — developmental biology — Posted on 2022-02-14

1888 FiNN: A toolbox for neurophysiological network analysis

Scherer, M.; Wang, T.; Guggenberger, R.; Milosevic, L.; Gharabaghi, A.

10.1101/2022.02.11.479403 — neuroscience — Posted on 2022-02-14

1889 Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Zalachoras, I.; Ramos-Fernandez, E.; Hollis, F.; Trovo, L.; Rodrigues, J.; Strasser, A.; Zanoletti, O.; Steiner, P.; Preitner, N.; Xin, L.; Astori, S.; Sandi, C.

10.1101/2022.02.14.480343 — neuroscience — Posted on 2022-02-14

1890 A DROSOPHILA CIRCUIT FOR HABITUATION OVERRIDE

Trisal, S.; Aranha, M. M.; Chodankar, A.; Vijayraghavan, K.; Ramaswami, M.

10.1101/2021.09.11.459900 — neuroscience — Posted on 2022-02-14

1891 Residual force enhancement within the human quadriceps is greatest during submaximal stretch-hold contractions at a very long muscle length

Bakenecker, P.; Weingarten, T.; Hahn, D.; Raiteri, B. J.

10.1101/2022.02.11.480120 — physiology — Posted on 2022-02-14

1892 A pili-driven bacterial turbine

Poenisch, W.; Zaburdaev, V.

10.1101/2022.02.14.480354 — biophysics — Posted on 2022-02-14

1893 In silico drug design of benzothiadiazine derivatives interactingwith bilayer cell membranes

Hu, Z.; Marti, J.

10.1101/2022.02.14.480348 — biophysics — Posted on 2022-02-14

1894 RNA triplex structures revealed by WAXS-driven MD simulations

Chen, Y. L.; He, W.; Kirmizialtin, S.; Pollack, L.

10.1101/2022.02.13.480274 — biophysics — Posted on 2022-02-14

1895 Solution structure of the phosphatidylinositol 3-phosphate binding domain from the Legionella effector SetA

Beck, W. H. J.; Enoki, T. A.; Wu, X.; Zhang, Q.; Nicholson, L. K.; Oswald, R. E.; Mao, Y.

10.1101/2022.02.13.480292 — biophysics — Posted on 2022-02-14

1896 Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

Shi, Y.; Zhou, Q.; Zhu, X.; Huang, G.; Zeng, C.; Zhan, X.; Liang, K.; Wang, Q.; Zhao, Y.; Lei, J.; Liu, M.; Wang, P.; Tao, Q.; Yan, C.

10.1101/2022.02.14.480321 — biophysics — Posted on 2022-02-14

1897 Improved structural variant discovery in hard-to-call regions using sample-specific string detection from accurate long reads

Denti, L.; Khorsand, P.; Bonizzoni, P.; Hormozdiari, F.; Chikhi, R.

10.1101/2022.02.12.480198 — bioinformatics — Posted on 2022-02-14

1898 Getting Personal with Epigenetics: Towards Machine-Learning-Assisted Precision Epigenomics

Hawkins-Hooker, A.; Visona, G.; Narendra, T.; Rojas-Carulla, M.; Schölkopf, B.; Schweikert, G.

10.1101/2022.02.11.479115 — bioinformatics — Posted on 2022-02-14

1899 Computer vision for assessing species color pattern variation from web-based community science images

Hantak, M. M.; Guralnick, R. P.; Zare, A.; Stucky, B. J.

10.1101/2022.02.11.480114 — bioinformatics — Posted on 2022-02-14

1900 Joint structural annotation of small molecules using liquid chromatography retention order and tandem mass spectrometry data

Bach, E.; Schymanski, E.; Rousu, J.

10.1101/2022.02.11.480137 — bioinformatics — Posted on 2022-02-14

1901 An evolutionarily conserved mechanism for control the translation of long proteins

Zheng, X.; Chen, H.; Deng, Z.; Wu, Y.; Wu, C.; Zhong, L.; Yan, S.

10.1101/2022.02.13.480182 — biochemistry — Posted on 2022-02-14

1902 An optimized method to infer relatedness up to the 5th degree from low coverage ancient human genomes

Nyerki, E.; Kalmar, T.; Schütz, O.; Lima, R. M.; Neparaczki, E.; Török, T.; Maroti, Z.

10.1101/2022.02.11.480116 — genetics — Posted on 2022-02-14

1903 hibayes: An R Package to Fit Individual-Level, Summary-Level and Single-Step Bayesian Regression Models for Genomic Prediction and Genome-Wide Association Studies

Yin, L.; Zhang, H.; Li, X.; Zhao, S.; Liu, X.

10.1101/2022.02.12.480230 — genetics — Posted on 2022-02-14

1904 Patterns of item nonresponse behavior to survey questionnaires are systematic and have a genetic basis

Mignogna, G.; Carey, C. E.; Wedow, R.; Baya, N.; Cordioli, M.; Pirastu, N.; Bellocco, R.; Nivard, M. G.; Neale, B. M.; Walters, R. K.; Ganna, A.

10.1101/2022.02.11.480140 — genetics — Posted on 2022-02-14

1905 Density dependence generates spatial overdispersion in adult tropical trees

Kalyuzhny, M.; Lake, J. K.; Wright, S. J.; Ostling, A. M.

10.1101/2022.02.12.480223 — ecology — Posted on 2022-02-14

1906 Conserved basal lamina proteins, laminin and nidogen, are repurposed to organize mechanosensory complexes responsible for touch sensation.

Das, A.; Franco, J. A.; Wang, L.; Chapman, D.; Wang, L. M.; Jaisinghani, C.; Pruitt, B.; Goodman, M. B.

10.1101/2022.02.11.479800 — cell biology — Posted on 2022-02-14

1907 Intercontinental movement of H5 2.3.4.4 Highly Pathogenic Avian Influenza A(H5N1) to the United States, 2021

Bevins, S. N.; Shriner, S. A.; Cumbee, J. C.; Dilione, K. E.; Douglass, K. E.; Ellis, J. W.; Killian, M. L.; Torchetti, M. K.; Lenoch, J. B.

10.1101/2022.02.11.479922 — microbiology — Posted on 2022-02-14

1908 Functional MRI reveals memories of mother in newborn chicks

Behroozi, M.; Lorenzi, E.; Tabrik, S.; Tegenthoff, M.; Gozzi, A.; Guentuerkuen, O.; Vallortigara, G.

10.1101/2022.02.12.480179 — neuroscience — Posted on 2022-02-14

1909 Learning vs. minding: How subjective costs can mask motor learning

Healy, C. M.; Berniker, M.; Ahmed, A. A.

10.1101/2022.02.11.479978 — neuroscience — Posted on 2022-02-14

1910 Ghrelin receptor signaling contributes to fasting-induced suppression of conditioned avoidance behavior and neural circuit activation in male rats

Edwards, C. M.; Dolezel, T.; Rinaman, L.

10.1101/2022.02.11.480168 — neuroscience — Posted on 2022-02-14

1911 In-vivo estimation of axonal morphology from MRI and EEG data

Oliveira, R.; Pelentritou, A.; Di Domenicantonio, G.; De Lucia, M.; Lutti, A.

10.1101/2022.02.11.479116 — neuroscience — Posted on 2022-02-14

1912 Decoding Dynamically Shifting States of Parkinson's Disease: Tremor, Bradykinesia, and Effective Motor Control

Lauro, P. M.; Lee, S.; Amaya, D. E.; Liu, D. D.; Akbar, U.; Asaad, W. F.

10.1101/2022.02.12.480213 — neuroscience — Posted on 2022-02-14

1913 Ventral motor thalamic input to prelimbic cortex, but not to striatum, mediates cost-benefit decision-making in rats

Sieveritz, B.; Hayashi Duke, S.; Wickens, J. R.; Arbuthnott, G. W.

10.1101/2022.02.11.480170 — neuroscience — Posted on 2022-02-14

1914 In vivo calcium imaging identifies functionally and molecularly distinct subsets of tongue-innervating mechanosensory neurons

Moayedi, Y.; Xu, S.; Obayashi, S. K.; Hoffman, B. U.; Gerling, G. J.; Lumpkin, E. A.

10.1101/2022.02.11.480171 — neuroscience — Posted on 2022-02-14

1915 Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Shoda, J.; Tanaka, S.; Etori, K.; Hattori, K.; Kasuya, T.; Ikeda, K.; Maezawa, Y.; Suto, A.; Suzuki, K.; Nakamura, J.; Maezawa, Y.; Takemoto, M.; Betsholtz, C.; Yokote, K.; Ohtori, S.; Nakajima, H.

10.1101/2022.02.12.480222 — pathology — Posted on 2022-02-14

1916 The OncoLoop network-based precision oncology framework

Vasciaveo, A.; Zou, M.; Arriaga, J. M.; Geraldes de Almeida, F.; Douglass, E. F.; Shibata, M.; Rodriguez-Calero, A.; de Brot, S.; Mitrofanova, A.; Chua, C. W.; Karan, C.; Realubit, R.; Pampou, S. Y.; Kim, J. Y.; Corey, E.; Alvarez, M.; Rubin, M. A.; Shen, M. M.; Califano, A.; Abate-Shen, C.

10.1101/2022.02.11.479456 — cancer biology — Posted on 2022-02-14

1917 Control of protein-based pattern formation via guiding cues

Burkart, T.; Wigbers, M. C.; Würthner, L.; Frey, E.

10.1101/2022.02.11.480095 — biophysics — Posted on 2022-02-14

1918 Scalable sequence database search using Partitioned Aggregated Bloom Comb-Trees

Marchet, C.; Limasset, A.

10.1101/2022.02.11.480089 — bioinformatics — Posted on 2022-02-14

1919 WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data

Hill, B.; Husz, Z.; Armit, C.; Davidson, D. R.; Murphy, P.; Baldock, R. A.

10.1101/2022.02.11.480105 — bioinformatics — Posted on 2022-02-14

1920 Examining clustered somatic mutations with SigProfilerClusters

Bergstrom, E. N.; Kundu, M.; Tbeileh, N.; Alexandrov, L. B.

10.1101/2022.02.11.480117 — bioinformatics — Posted on 2022-02-14

1921 Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles

Rezvani, Y.; Keroack, C. D.; Elsworth, B.; Arriojas, A.; Gubbels, M.-J.; Duraisingh, M.; Zarringhalam, K.

10.1101/2022.02.11.480160 — bioinformatics — Posted on 2022-02-14

1922 Optimisation-based modelling for drug discovery in malaria

Li, Y.; Cardoso-Silva, J.; Papageorgiou, L. G.; Tsoka, S.

10.1101/2022.02.12.479469 — bioinformatics — Posted on 2022-02-14

1923 DILIc: An AI-based classifier to search for Drug-Induced Liver Injury literature

Rathee, S.; MacMahon, M.; Liu, A.; Katritsis, N.; Youssef, G.; Hwang, W.; Wollman, L.; Han, N.

10.1101/2022.02.12.480184 — bioinformatics — Posted on 2022-02-14

1924 A Self-attention Graph Convolutional Network for Precision Multi-tumour Early Diagnostics with DNA Methylation Data

Jiang, X.; Li, Z.; Wang, H.; Chu, Y.; Wang, Q.; Mao, X.; Zhao, J.; Jiang, M.; Zhao, B.; Xiong, Y.; Wang, E.; Wei, D.-q.

10.1101/2022.02.11.480173 — bioinformatics — Posted on 2022-02-14

1925 Molecular Characterization in 3D Structure of MicroRNA Expressed in Leprosy

de Oliveira Andrade, L. J.; Barreto de Jesus, H.; Matos de Oliveira, L.; Farias de Oliveira, M.; Caricchio Santana, L. F.; Matos de Oliveira, G. C.

10.1101/2022.02.11.480165 — bioinformatics — Posted on 2022-02-14

1926 Navigation of Ultrasound-controlled Swarmbots under Physiological Flow Conditions

Fonseca, A. D. C.; Kohler, T.; Ahmed, D.

10.1101/2022.02.11.480088 — bioengineering — Posted on 2022-02-14

1927 Characterization of the Interaction of Nanobubble Ultrasound Contrast Agents with Human Blood Components

Cooley, M. B.; Abenojar, E. C.; Wegierak, D.; Sen Gupta, A.; Kolios, M. C.; Exner, A. A.

10.1101/2022.02.11.480110 — bioengineering — Posted on 2022-02-14

1928 DNA-functionalized Gold Nanorods for Targeted Triple-modal Optical Imaging and Photothermal Therapy of Triple-negative Breast Cancer

Pal, S.; Koneru, J. K.; Andreou, C.; Rakshit, T.; Rajasekhar, V.; Wlodarczyk, M.; Healey, J. H.; Kircher, M.; Mondal, J.

10.1101/2022.02.12.480219 — bioengineering — Posted on 2022-02-14

1929 Divergence amid recurring gene flow: complex demographic processes during speciation are the growing expectation for forest trees

Bolte, C. E.; Faske, T. M.; Friedline, C. J.; Eckert, A. J.

10.1101/2022.02.12.480138 — evolutionary biology — Posted on 2022-02-14

1930 Zoogeographic patterns on very small spatial scales in rock-dwellingPlectostoma snails from Borneo(Gastropoda: Caenogastropoda: Diplommatinidae)

Schilthuizen, M.; van Til, A.

10.1101/2022.02.13.480235 — evolutionary biology — Posted on 2022-02-14

1931 Differential adaptive potential and vulnerability to climate-driven habitat loss in Brazilian mangroves

Vidal, J. d. D.; Mori, G. M.; Cruz, M. V.; da Silva, M. F.; de Moura, Y. A.; de Souza, A. P.

10.1101/2022.02.11.480143 — evolutionary biology — Posted on 2022-02-14

1932 The global exposure of species ranges and protected areas to forest management

Jung, M.; Lewis, M.; Lesiv, M.; Arnell, A.; Fritz, S.; Visconti, P.

10.1101/2022.02.11.480150 — ecology — Posted on 2022-02-14

1933 Positional Context of Myonuclear Transcription during Injury-induced Muscle Regeneration

Buckley, K. H.; Nestor-Kalinoski, A. L.; Pizza, F. X.

10.1101/2022.02.11.480101 — cell biology — Posted on 2022-02-14

1934 Investigating the effect of obesity on adipose-derived stem cells (ASCs) using Gottingen Minipigs

Meyhoff-Madsen, M.; Ostrup, E.; Fredholm, M.; Cirera, S.

10.1101/2022.02.11.477943 — cell biology — Posted on 2022-02-14

1935 Neurophysiological Measures Of Auditory Sensory Processing Are Associated With Adaptive Behavior In Children With Autism Spectrum Disorder

Cotter, M.; Tikir, S.; Francisco, A. A.; Oakes, L.; Crosse, M. J.; Foxe, J. J.; Molholm, S.

10.1101/2022.02.11.480113 — neuroscience — Posted on 2022-02-14

1936 The Genetics of Participation: Method and Analysis

Benonisdottir, S.; Kong, A.

10.1101/2022.02.11.480067 — genetics — Posted on 2022-02-14

1937 Shared responsibility decreases the sense of agency in the human brain

El Zein, M.; Dolan, R. J.; Bahrami, B.

10.1101/2021.08.20.457115 — neuroscience — Posted on 2022-02-14

1938 Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

Vasilevskaya, A.; Widmer, F. C.; Keller, G. B.; Jordan, R.

10.1101/2022.02.11.479795 — neuroscience — Posted on 2022-02-14

1939 Xlnc1DCNN: An Explainable Long Non-Coding RNA Identification Tool

Lin, R.; Wichadakul, D.

10.1101/2022.02.11.479495 — bioinformatics — Posted on 2022-02-14

1940 An attempt of using public ambient temperature data in swine genetic evaluation for litter size traits at birth in Japan

Hara, H.; Ogawa, S.; Ohnishi, C.; Ishii, K.; Umoto, Y.; Satoh, M.

10.1101/2022.02.09.479814 — genetics — Posted on 2022-02-14

1941 Evolution of a cis-acting SNP that controls Type VI Secretion in Vibrio cholerae

Ng, S. L.; Kammann, S. A.; Steinbach, G.; Hoffmann, T.; Yunker, P. J.; Hammer, B. K.

10.1101/2022.01.11.475911 — microbiology — Posted on 2022-02-14

1942 Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states

Schimke, L. F.; Marques, A. H.; Baiocchi, G. C.; Prado, C. A.; Fonseca, D. L.; Freire, P. P.; Placa, D. R.; Filgueira, I. S.; Salgado, R. C.; Jansen-Marques, G.; Oliveira, A. E.; Peron, J. P. S.; Cabral Miranda, G.; Barbuto, J. A. M.; Camara, N. O. S.; Calich, V. L.; Ochs, H. D.; Condino-Neto, A.; Overmyer, K. A.; Coon, J. J.; Balnis, J.; Jaitovich, A.; Schulte-Schrepping, J.; Ulas, T.; Schultze, J. L.; Nakaya, H. I.; Jurisica, I.; Marques, O. C.

10.1101/2021.07.30.454529 — immunology — Posted on 2022-02-14

1943 Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Li, D.; Martinez, D. R.; Schäfer, A.; Chen, H.; Barr, M.; Sutherland, L. L.; Lee, E.; Parks, R.; Mielke, D.; Edwards, W.; Newman, A.; Bock, K. W.; Minai, M.; Nagata, B. M.; Gagne, M.; Douek, D.; DeMarco, C. T.; Denny, T. N.; Oguin, T. H.; Brown, A.; Rountree, W.; Wang, Y.; Mansouri, K.; Edwards, R. J.; Ferrari, G.; Sempowski, G. D.; Eaton, A.; Tang, J.; Cain, D. W.; Santra, S.; Pardi, N.; Weissman, D.; Tomai, M.; Fox, C.; Moore, I. N.; Andersen, H.; Lewis, M. G.; Golding, H.; Khurana, S.; Seder, R.; Baric, R. S.; Montefiori, D. C.; Saunders, K. O.; Haynes, B. F.

10.1101/2022.01.26.477915 — immunology — Posted on 2022-02-14

1944 Shoulder muscle recruitment during the delay period encodes a reach movement plan which is sensitive to task context

Rungta, S. P.; Murthy, A.

10.1101/2022.02.09.479690 — neuroscience — Posted on 2022-02-14

1945 Proprioceptive and visual feedback responses in macaques exploit goal redundancy

Cross, K. P.; Guang, H.; Scott, S. H.

10.1101/2022.02.11.480080 — neuroscience — Posted on 2022-02-14

1946 Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

Neyret-Kahn, H.; Fontugne, J.; Meng, X.-Y.; Groeneveld, C. S.; Cabel, L.; Ye, T.; Guyon, E.; Krucker, C.; Dufour, F.; Chapeaublanc, E.; Rapinat, A.; Jeffery, D. C. B.; Neuzillet, Y.; Lebret, T.; Gentien, D.; Davidson, I.; Allory, Y.; Bernard-Pierrot, I.; Radvanyi, F.

10.1101/2022.01.11.475197 — cancer biology — Posted on 2022-02-14

1947 Pseudotime analysis reveals novel regulatory factors for multigenic onset and monogenic transition of odorant receptor expression

Hussainy, M.; Korsching, S. I.; Tresch, A.

10.1101/2022.01.31.478392 — bioinformatics — Posted on 2022-02-14

1948 Multi-modal single-cell and whole-genome sequencing of minute, frozen specimens to propel clinical applications

Wang, Y.; Fan, J. L.; Melms, J. C.; Amin, A. D.; Georgis, Y.; Ho, P.; Tagore, S.; Abril-Rodriguez, G.; Biermann, J.; Hofree, M.; Caprio, L.; Berhe, S.; Khan, S. A.; Henick, B. S.; Ribas, A.; Taylor, A. M.; Schwartz, G. K.; Carvajal, R. D.; Azizi, E.; Izar, B.

10.1101/2022.02.13.480272 — genomics — Posted on 2022-02-14

1949 Social information use shapes the coevolution of sociality and virulence

Ashby, B.; Farine, D. R.

10.1101/2020.10.02.323451 — evolutionary biology — Posted on 2022-02-14

1950 Modeling the stepwise extension of recombination suppression on sex chromosomes and other supergenes through deleterious mutation sheltering

Jay, P.; Giraud, T.; Tezenas, E.; Veber, A.

10.1101/2021.05.17.444504 — evolutionary biology — Posted on 2022-02-14

1951 Imbalanced segregation of recombinant haplotypes in hybrid populations reveals inter- and intrachromosomal Dobzhansky-Muller incompatibilities

Li, J.; Schumer, M.; Bank, C.

10.1101/2021.08.04.454891 — evolutionary biology — Posted on 2022-02-14

1952 A Gut Microbial Peptide and Molecular Mimicry in the Pathogenesis of Type 1 Diabetes

Girdhar, K.; Huang, Q.; Chow, I.-T.; Brady, C.; Raisingani, A.; Autissier, P.; Atkinson, M. A.; Kwok, W. W.; Kahn, C. R.; ALTINDIS, E.

10.1101/2020.10.22.350801 — immunology — Posted on 2022-02-14

1953 Possible Cross Reactivity of Feline and White-tailed Deer Antibodies Against the SARS-CoV-2 Receptor Binding Domain

Hancock, T. J.; Hickman, P.; Kazerooni, N.; Kennedy, M.; Kania, S. A.; Dennis, M.; Szafranski, N.; Gerhold, R. W.; Su, C.; Masi, T. J.; Smith, S.; Sparer, T. E.

10.1101/2021.12.17.473265 — immunology — Posted on 2022-02-14

1954 The impact of obesity; key features of raised intracranial pressure and clinical sequalae in rodents

Westgate, C. S. J.; Hagen, S. M.; Israelsen, I. M. E.; Hamann, S. E.; Jensen, R.; Eftekhari, S.

10.1101/2021.08.05.455266 — neuroscience — Posted on 2022-02-14

1955 Moving Beyond the 'CAP' of the Iceberg: Intrinsic Connectivity Networks in fMRI are Continuously Engaging and Overlapping

Iraji, A.; Faghiri, A.; Fu, Z.; Kochunov, P.; Adhikari, B. M.; Belger, A.; Ford, J. M.; McEwen, S.; Mathalon, D. H.; Pearlson, G. D.; Potkin, S. G.; Preda, A.; Turner, J. A.; Van Erp, T. G. M.; Chang, C.; Calhoun, V. D.

10.1101/2021.06.23.449485 — neuroscience — Posted on 2022-02-14

1956 High-Intensity Interval Training Remodels the Proteome and Acetylome of Human Skeletal Muscle

Hostrup, M.; Lemminger, A. K.; Stocks, B.; Gonzalez-Franquesa, A.; Larsen, J. K.; Prats, J. Q.; Thomassen, M.; Weinert, B.; Bangsbo, J.; Deshmukh, A. S.

10.1101/2021.02.10.430602 — physiology — Posted on 2022-02-14

1957 Obesity affects mitochondrial metabolism and proliferative potential of equine endometrial progenitor cells.

Smieszek, A.; Marcinkowska, K.; Pielok, A.; Sikora, M.; Valihrach, L.; Carnevale, E.; Marycz, K.

10.1101/2021.12.02.470884 — cell biology — Posted on 2022-02-14

1958 Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum

Forrester, S.; Goundry, A. L.; Dias, B. T.; Leal-Calvo, T.; Moraes, M.; Kaye, P.; Mottram, J.; Lima, A. P. C. A.

10.1101/2022.02.04.479211 — microbiology — Posted on 2022-02-14

1959 Time-adaptive Unsupervised Auditory Attention Decoding Using EEG-based Stimulus Reconstruction

Geirnaert, S.; Francart, T.; Bertrand, A.

10.1101/2022.01.07.475386 — neuroscience — Posted on 2022-02-14

1960 Inverse Problem Reveals Conditions for Characteristic Retinal Degeneration Patterns in Retinitis Pigmentosa under the Trophic Factor Hypothesis

Roberts, P. A.

10.1101/2021.09.04.458968 — systems biology — Posted on 2022-02-14

1961 The evolution of color naming reflects pressure for efficiency: Evidence from the recent past

Zaslavsky, N.; Garvin, K.; Kemp, C.; Tishby, N.; Regier, T.

10.1101/2021.11.03.467047 — animal behavior and cognition — Posted on 2022-02-14

1962 Genomic databanks and targeted assays help characterise domestic mosquito incursions

Schmidt, T. L.; Endersby-Harshman, N.; Kurucz, N.; Pettit, W.; Krause, V.; Ehlers, G.; Muzari, O.; Currie, B. J.; Hoffmann, A. A.

10.1101/2022.01.19.477022 — genomics — Posted on 2022-02-14

1963 Population-based structure modeling reveals key roles of nuclear microenvironment in gene functions

Yildirim, A.; Hua, N.; Boninsegna, L.; Polles, G.; Gong, K.; Hao, S.; Li, W.; Zhou, X. J.; Alber, F.

10.1101/2021.07.11.451976 — genomics — Posted on 2022-02-14

1964 Distinctiveness and continuity in transcriptome and connectivity in the anterior-posterior axis of the paraventricular nucleus of thalamus

Shima, Y.; Skibbe, H.; Sasagawa, Y.; Fujimori, N.; Nikaido, I.; Hattori, N.; Kato, T.

10.1101/2022.02.13.480207 — neuroscience — Posted on 2022-02-14

1965 Early loss of endogenous NAD+ following rotenone treatment leads to Sarm1 induction that is ameliorated by PARP inhibition

Sarkar, A.; Sur, M.; Dutta, S.; Dey, P.; Mukherjee, P.

10.1101/2021.07.30.454548 — cell biology — Posted on 2022-02-13

1966 CMash: fast, multi-resolution estimation of k-mer-based Jaccard and containment indices

Liu, S.; Koslicki, D.

10.1101/2021.12.06.471436 — bioinformatics — Posted on 2022-02-13

1967 Close kin dyads indicate intergenerational dispersal and barriers

Schmidt, T. L.; Elfekih, S.; Cao, L.-J.; Wei, S.-J.; Al-Fageeh, M.; Nassar, M.; Al-Malik, A.; Hoffmann, A. A.

10.1101/2022.01.18.476819 — genetics — Posted on 2022-02-13

1968 Historical contingency drives compensatory evolution and rare reversal of phage resistance

Debray, R.; De Luna, N.; Koskella, B.

10.1101/2022.02.10.479996 — evolutionary biology — Posted on 2022-02-13

1969 A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia

Voit, R. A.; Tao, L.; Yu, F.; Cato, L. D.; Cohen, B.; Liao, X.; Fiorini, C.; Nandakumar, S. K.; Wahlster, L.; Teichert, K.; Regev, A.; Sankaran, V. G.

10.1101/2021.12.09.471942 — cell biology — Posted on 2022-02-13

1970 CellKb Immune: a manually curated database of mammalian hematopoietic marker gene sets for rapid cell type identification

Patil, A.; Patil, A.

10.1101/2020.12.01.389890 — immunology — Posted on 2022-02-13

1971 Whole-genome resequencing reveals the population structure, genomic diversity, and demographic history of American chestnut (Castanea dentata)

Sandercock, A. M.; Westbrook, J. W.; Zhang, Q.; Johnson, H.; Saielli, T. M.; Scrivani, J. A.; Fitzsimmons, S.; Collins, K.; Schmutz, J.; Grimwood, J.; Holliday, J. A.

10.1101/2022.02.11.480151 — genomics — Posted on 2022-02-13

1972 A novel Bayesian factor analysis method improves detection of genes and biological processes affected by perturbations in single-cell CRISPR screening

Zhou, Y.; Luo, K.; Chen, M.; He, X.

10.1101/2022.02.13.480282 — genomics — Posted on 2022-02-13

1973 Improved Metagenomic Binning with Transformers

Shenker-Tauris, N.; Gehrig, J.

10.1101/2022.02.12.479459 — genomics — Posted on 2022-02-13

1974 Multi-modal single-cell and whole-genome sequencing of minute, frozen specimens to propel clinical applications

10.1101/2022.02.13.480272 — genomics — Posted on 2022-02-13

1975 Genetic analysis of C. elegans Haspin-like genes shows that hasp-1 plays multiple roles in the germline

Macaraeg, J.; Reinhard, I.; Ward, M.; Carmeci, D.; Stanaway, M.; Moore, A.; Hagmann, E.; Brown, K.; Wynne, D. J.

10.1101/2022.02.12.480216 — genetics — Posted on 2022-02-13

1976 Strength of stabilizing selection on the amino-acid sequence is associated with the amount of non-additive variance in gene expression.

Takou, M.; Balick, D. J.; Steige, K. A.; Dittberner, H.; Göbel, U.; Schielzeth, H.; de Meaux, J.

10.1101/2022.02.11.480164 — genetics — Posted on 2022-02-13

1977 Reversions to consensus are positively selected in HIV-1 and bias substitution rate estimates

Druelle, V.; Neher, R.

10.1101/2022.02.13.480259 — evolutionary biology — Posted on 2022-02-13

1978 Speciation in Nearctic oak gall wasps is frequently correlated with changes in host plant, host organ, or both.

Ward, A. K. G.; Bagley, R. K.; Egan, S. P.; Hood, G. R.; Ott, J. R.; Prior, K. M.; Sheikh, S. I.; Weinersmith, K. L.; Zhang, L.; Zhang, Y. M.; Forbes, A. A.

10.1101/2022.02.11.480154 — evolutionary biology — Posted on 2022-02-13

1979 Cross-modality Synthesis of EM Time Series and Live Fluorescence Imaging

Santella, A.; Kolotueva, I.; Kizilyaprak, C.; Bao, Z.

10.1101/2022.02.11.480136 — developmental biology — Posted on 2022-02-13

1980 Polymorphic ribonucleoprotein folding as a basis for translational regulation

Dendooven, T.; Sonnleitner, E.; Blasi, U.; Luisi, B.

10.1101/2022.02.11.480102 — molecular biology — Posted on 2022-02-12

1981 Improved Predictions Of MHC-Peptide Binding Using Protein Language Models

Hashemi, N.; Hao, B.; Ignatov, M.; Paschalidis, I.; Vakili, P.; Vajda, S.; Kozakov, D.

10.1101/2022.02.11.479844 — molecular biology — Posted on 2022-02-12

1982 Relevance study of vector competence and insecticide resistance in Aedes aegypti laboratory lines

Wang, L.; Fontaine, A.; Gaborit, P.; Guidez, A.; Issaly, J.; Girod, R.; Kazanji, M.; Rousset, D.; Vignuzzi, M.; Epelboin, Y.; Dusfour, I.

10.1101/2022.02.12.480187 — molecular biology — Posted on 2022-02-13

1983 Why FIT and bHLH Ib interdependently regulate Fe-uptake

Cai, Y. R.; Yang, Y.; Ping, H.; Lu, C.; Lei, R.; Li, Y.; Liang, G.

10.1101/2022.02.12.480172 — molecular biology — Posted on 2022-02-13

1984 Bacterial outer-membrane polysaccharide export (OPX) proteins occupy three structural classes with selective β-barrel porin requirements for polymer secretion

Saïdi, F.; Mahanta, U.; Panda, A.; Jolivet, N. Y.; Bitazar, R.; John, G.; Martinez, M.; Mellouk, A.; Calmettes, C.; Chang, Y.-W.; Sharma, G.; Islam, S. T.

10.1101/2022.02.11.480155 — microbiology — Posted on 2022-02-12

1985 Fitness costs of pfhrp2 and pfhrp3 deletions underlying diagnostic evasion in malaria parasites

Nair, S.; Li, X.; Nkhoma, S.; Anderson, T. J.

10.1101/2022.02.11.480127 — microbiology — Posted on 2022-02-12

1986 Sequence-based Functional Metagenomics Reveals Novel Natural Diversity of Functioning CopA in Environmental Microbiomes

Li, W.; Wang, L.; Li, X.; Zheng, X.; Cohen, M. F.; Liu, Y.-X.

10.1101/2022.02.12.480192 — microbiology — Posted on 2022-02-12

1987 Discovery of Flaviviridae-derived endogenous viral elements in shrew genomes provide novel insights into Pestivirus ancient history

Li, Y.; Bletsa, M.; Zisi, Z.; Boonen, I.; Gryseels, S.; Kafetzopoulou, L.; Webster, J. P.; Pybus, O. G.; Van de Perre, F.; Li, H.; Li, Y.; Li, Y.; Abramov, A.; Lymberakis, P.; Lemey, P.; Lequime, S.

10.1101/2022.02.11.480044 — microbiology — Posted on 2022-02-12

1988 The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

Jangir, P. K.; Ogunlana, L.; Szili, P.; Czikkely, M.; Stevens, E. J.; Yang, Y.; Yang, Q.; Wang, Y.; Pal, C.; Walsh, T. R.; MacLean, C.

10.1101/2022.02.12.480185 — microbiology — Posted on 2022-02-12

1989 Shrimp vaccination with insect-adapted yellow head virus (YHV) extends survival upon YHV challenge

Gangnonngiw, W.; Kanthong, N.

10.1101/2022.02.13.480220 — microbiology — Posted on 2022-02-13

1990 Metagenomes of Red Sea subpopulations challenge the use of morphology and marker genes to assess Trichodesmium diversity

Koedooder, C.; Landou, E.; Zhang, F.; Wang, S.; Basu, S.; Berman-Frank, I.; Shaked, Y.; Rubin Blum, M.

10.1101/2022.02.13.480231 — microbiology — Posted on 2022-02-13

1991 Metagenomic and Metabolomic Analyses Reveal Synergistic Effects of Fecal Microbiota Transplantation and Anti-PD-1 Therapy on Treating Colorectal Cancer

Huang, J.; Zheng, X.; Kang, W.; Hao, H.; Mao, Y.; Zhang, H.; Chen, Y.; Tan, Y.; He, Y.; Zhao, W.; Yin, Y.

10.1101/2022.02.13.480233 — microbiology — Posted on 2022-02-13

1992 Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by multi-omic analysis

Kunath, B. J.; Hickl, O.; Queiros, P. T.; Martin-Gallausiaux, C.; Lebrun, L.; Halder, R.; Laczny, C. C.; Schmidt, T. S.; Becher, D.; Heintz-Buschart, A.; Debeaufort, C.; Borg, P.; May, P.; Wilmes, P.

10.1101/2022.02.13.480246 — microbiology — Posted on 2022-02-13

1993 Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis

Martini, M. C.; Hicks, N. D.; Xiao, J.; Barbier, T.; Sixsmith, J.; Fortune, S. M.; Shell, S. S.

10.1101/2022.02.13.480260 — microbiology — Posted on 2022-02-13

1994 Vaccine-elicitation of cross-group neutralizing protective antibodies to influenza A viruses

Moin, S. M.; Boyington, J. C.; Boyoglu-Barnum, S.; Gillespie, R. A.; Cerutti, G.; Cheung, C. S.-F.; Cagigi, A.; Gallagher, J. R.; Brand, J.; Prabhakaran, M.; Tsybovsky, Y.; Stephens, T.; Fisher, B. E.; Creanga, A.; Ataca, S.; Rawi, R.; Corbett, K. S.; Crank, M. C.; Gorman, J.; McDermott, A. B.; Harris, A. K.; Zhou, T.; Kwong, P. D.; Shapiro, L.; Mascola, J. R.; Graham, B. S.; Kanekiyo, M.

10.1101/2022.02.11.480115 — immunology — Posted on 2022-02-12

1995 Multidimensional single-cell analysis identifies a role of CD2-CD58 interactions for clinical antitumor T cell responses

Romain, G.; Strati, P.; Rezvan, A.; Fathi, M.; Bandey, I. N.; Adolacion, J. R. T.; Heeke, D.; Liadi, I.; Marques-Piubelli, M. L.; Solis, L. M.; Mahendra, A.; Vega, F.; Cooper, L. J.; Singh, H.; Mattie, M.; Bot, A.; Neelapu, S.; Varadarajan, N.

10.1101/2022.02.11.479825 — immunology — Posted on 2022-02-12

1996 The sialidase NEU3 promotes pulmonary fibrosis in mice

Pilling, D.; Sahlberg, K.; Karhadkar, T. R.; Chen, W.; Gomer, R. H.

10.1101/2022.02.12.480197 — immunology — Posted on 2022-02-12

1997 Prediction error processing speeds up in presence of multisensory contexts

Talwar, S.; Ghosh, P.; Banerjee, A.

10.1101/2022.02.11.480053 — neuroscience — Posted on 2022-02-12

1998 Alpha-Amylase increases predict a freezing-like response and cortical alpha oscillations

Luther, L.; Hagenaars, M. A.; Jensen, O.

10.1101/2022.02.11.480062 — neuroscience — Posted on 2022-02-12

1999 The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

Ji, H.; Wang, B.; Labib, D.; Lei, J.; Chen, X.; Sapar, M.; Boulanger, A.; Dura, J.-M.; Han, C.

10.1101/2022.02.11.480148 — neuroscience — Posted on 2022-02-12

2000 Neurodevelopmental Patterns of Early Postnatal White Matter Maturation Represent Distinct Underlying Microstructure and Histology

10.1101/2022.02.11.480169 — neuroscience — Posted on 2022-02-13

2001 Mentalizing in economic games is associated with enhanced activation and connectivity in left temporoparietal junction

Chang, L.-A.; Warns, L.; Armaos, K.; Ma de Sousa, A. Q.; Paauwe, F.; Scholz, C.; Engelmann, J. B.

10.1101/2022.02.12.480201 — neuroscience — Posted on 2022-02-13

2002 Cerebral organoids for modeling of HSV-1-induced-multiscale neuropathology associated with Alzheimers disease and phenotypic rescue

Chen, P.; Qiao, H.; Zhao, W.; Guo, M.; Zhu, L.; Chen, T.; Wang, J.; Zhang, Z.; Wu, Y.

10.1101/2022.02.11.480178 — neuroscience — Posted on 2022-02-13

2003 Enhanced Sodium Channel Inactivation by Temperature and FHF2 Deficiency Blocks Heat Nociception

Marra, C.; Hartke, T.; Ringkamp, M.; Goldfarb, M.

10.1101/2022.02.12.480202 — neuroscience — Posted on 2022-02-13

2004 The zinc finger transcription factor Sall1 is required for the early developmental transition of microglia in mouse embryos

Scott, E. P.; Breyak, E.; Nishinakamura, R.; Nakagawa, Y.

10.1101/2022.02.12.480224 — neuroscience — Posted on 2022-02-13

2005 Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington's Disease

Beatriz, M.; Vilaca, R.; Anjo, S. I.; Manadas, B.; Rego, A. C.; Lopes, C.

10.1101/2022.02.13.480262 — neuroscience — Posted on 2022-02-13

2006 Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics

Castellano, D.; Wu, K.; Keramidas, A.; Lu, W.

10.1101/2022.02.11.480135 — neuroscience — Posted on 2022-02-13

2007 Biogeography and Validation of species limits in Caribbean Red Bats (Vespertilionidae: Lasiurus)

Soto-Centeno, J. A.; Calderon-Acevedo, C. A.

10.1101/2022.02.11.479705 — zoology — Posted on 2022-02-12

2008 Predatory mites, a green pesticide, and an Entomopathogenic compound: A proposed IPM tactic based on pest species diversity indices and population dynamics

Zidan, I. M.; El-Saiedy, E. M. A. K.; Abou-Elella, G. M.; Hasssan, M. F.

10.1101/2022.02.12.480204 — zoology — Posted on 2022-02-13

2009 A critique of common methods for comparing the scaling of vertical force production in flying insects

Burnett, N. P.; Keliher, E.; Combes, S. A.

10.1101/2022.02.11.480158 — zoology — Posted on 2022-02-13

2010 Non-destructive chemical sensing within bulk soil using 1000 biosensors per gram of matrix

Fulk, E. M.; Gao, X.; Lu, L. C.; Redeker, K. R.; Masiello, C. A.; Silberg, J. J.

10.1101/2022.02.11.480126 — synthetic biology — Posted on 2022-02-12

2011 Synthetic memory circuits for programmable cell reconfiguration in plants

Lloyd, J. P. B.; Ly, F.; Gong, P.; Pflueger, J.; Swain, T.; Pflueger, C.; Khan, M. A.; Kidd, B.; Lister, R.

10.1101/2022.02.11.480167 — synthetic biology — Posted on 2022-02-12

2012 Genomic characterization of a wild-like tomato accession found in Arizona; a northward migration story

Barnett, J. R.; Buonauro, G.; Kuipers, A.; Sapkota, M.; van der Knaap, E.; Razifard, H.

10.1101/2022.02.11.480156 — plant biology — Posted on 2022-02-12

2013 Conifer leaves have a peroxisomal oxidative decarboxylation path in the photorespiratory pathway

Miyazawa, S.-I.; Miyama, T.; Tahara, K.; Ujino-Ihara, T.; Tobita, H.; Suzuki, Y.; Nishiguchi, M.

10.1101/2022.02.11.480092 — plant biology — Posted on 2022-02-13

2014 Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters

Vacca, F.; Gomes, A.; Murashita, K.; Cinquetti, R.; Roseti, C.; Barca, A.; Ronnestad, I.; Verri, T.; Bossi, E.

10.1101/2022.02.11.480090 — physiology — Posted on 2022-02-12

2015 Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models.

Brown, B. J.; Boekell, K. L.; Stotter, B. R.; Talbot, B. E.; Schlondorff, J. S.

10.1101/2022.02.11.479954 — physiology — Posted on 2022-02-13

2016 Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice

McLendon, J. M.; Zhang, X.; Matasic, D.; Kumar, M.; Koval, O. M.; Grumbach, I. M.; Sadayappan, S.; London, B.; Boudreau, R.

10.1101/2022.02.13.480093 — physiology — Posted on 2022-02-13

2017 Molecular signature of RV cardiac remodeling associated with Polymerase Gamma mutation

Gorr, M. W.; Francois, A.; Marcho, L. M.; Saldana, T.; McGrail, E.; Sun, N.; Stratton, M.

10.1101/2022.02.11.480145 — pathology — Posted on 2022-02-12

2018 Kinase Suppressor of Ras 2 regulates small-cell lung carcinoma tumor propagating cells

Huisman, D. H.; Frodyma, D. E.; Svoboda, R. A.; Vieira, H. M.; Chatterjee, D.; Skupa, S.; Askew, J. A.; Fisher, K. W.; Kareta, M.; Oliver, T. G.; Lewis, R. E.

10.1101/2022.02.11.480157 — cancer biology — Posted on 2022-02-12

2019 The Role of Glycocalyx Steric Effects on Viral Endocytosis

Buckley, J.; Battaglia, G.

10.1101/2022.02.12.480189 — biophysics — Posted on 2022-02-12

2020 Differences in Ion-RNA binding modes due to charge density variations explain the stability of RNA in monovalent salts

Henning-Knechtel, A.; Thirumalai, D.; Kirmizialtin, S.

10.1101/2022.02.12.480180 — biophysics — Posted on 2022-02-12

2021 Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins

Dey, S.; MacAinsh, M.; Zhou, H.-X.

10.1101/2022.02.11.480128 — biophysics — Posted on 2022-02-12

2022 RNA velocity unraveled

Gorin, G.; Fang, M.; Chari, T.; Pachter, L.

10.1101/2022.02.12.480214 — biophysics — Posted on 2022-02-13

2023 pkgndep: a tool for heaviness analysis on R package dependencies

Gu, Z.; Huebschmann, D.

10.1101/2022.02.11.480073 — bioinformatics — Posted on 2022-02-12

2024 Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors

Gallego-Murillo, J. S.; Iacono, G.; van der Wielen, L. A. M.; van den Akker, E.; von Lindern, M.; Wahl, S. A.

10.1101/2022.02.11.480112 — bioengineering — Posted on 2022-02-12

2025 Live visualization of cytosolic and endoplasmic reticulum redox potential in zebrafish embryos reveals region-specific differences

Verma, M.; Bhatt, N. R.; Chaphalkar, A.; Verma, K.; Umale, S.; Verma, S.; Sachidanandan, C.; Chakraborty, K.

10.1101/2022.02.12.480199 — biochemistry — Posted on 2022-02-12

2026 Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

Chung, I.; Wright, J. J.; Bridges, H. R.; Ivanov, B. S.; Biner, O.; Pereira, C. S.; Arantes, G. M.; Hirst, J.

10.1101/2022.02.11.480065 — biochemistry — Posted on 2022-02-12

2027 Selection of Synthetic Proteins to Modulate the Human Frataxin Function

Pignataro, M. F.; Herrera, M. G.; Fernandez, N. B.; Aran, M.; Bataglini, F.; Santos, J.

10.1101/2022.02.11.480108 — biochemistry — Posted on 2022-02-12

2028 Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells

Orsburn, B. C.; Yuan, Y.; Bumpus, N. N.

10.1101/2022.02.12.480144 — biochemistry — Posted on 2022-02-12

2029 Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance

Yan, J.; Du, C.; Guan, X.

10.1101/2022.02.11.480111 — biochemistry — Posted on 2022-02-12

2030 Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter

Capper, M. J.; Yang, S.; Stone, A. C.; Vatansever, S.; Zilberg, G.; Mathiharan, Y. K.; Habib, R.; Hutchinson, K.; Schlessinger, A.; Mezei, M.; Osman, R.; Zhang, B.; Wacker, D.

10.1101/2022.02.11.480130 — biochemistry — Posted on 2022-02-12

2031 High-Resolution Tandem Mass Spectrometry Indicates Rubisco Activase is Associated with PS I-LHC I-LHC II Membranes

Kale, R. S.; Sallans, L.; Frankel, L. K.; Bricker, T. M.

10.1101/2022.02.13.480267 — biochemistry — Posted on 2022-02-13

2032 Generation and validation of an anti-human PANK3 mouse monoclonal antibody

Khadka, S.; Vien, L.; Leonard, P.; Bover, L.; Muller, F. L.

10.1101/2022.02.12.480208 — biochemistry — Posted on 2022-02-13

2033 Environmental contributions to the evolution of trait differences in Geum triflorum: implications for restoration

Volk, K.; Braasch, J.; Ahlering, M.; Hamilton, J.

10.1101/2022.02.11.480132 — evolutionary biology — Posted on 2022-02-12

2034 Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells.

van Leeuwen, W.; Nguyen, D. M. D.; Grond, R.; Veenendaal, T.; Farias, G. G.; Rabouille, C.

10.1101/2022.02.11.480147 — cell biology — Posted on 2022-02-12

2035 Evaluating brain parcellations using the distance controlled boundary coefficient

Zhi, D.; King, M.; Hernandez-Castillo, C. R.; Diedrichsen, J.

10.1101/2021.05.11.443151 — neuroscience — Posted on 2022-02-13

2036 Mathematical modeling of the effects of Wnt-10b on bone metabolism

Cook, C. V.; Islam, M. A.; Smith, B. J.; Ford Versypt, A. N.

10.1101/2021.06.12.448204 — systems biology — Posted on 2022-02-13

2037 Exploring the frame effect

Cavanagh, P.; Anstis, S.; Lisi, M.; Wexler, M.; Maechler, M.; 't Hart, B. M.; Shams-Ahmar, M.; Saleki, S.

10.1101/2022.02.10.479960 — neuroscience — Posted on 2022-02-13

2038 pkgndep: a tool for analyzing dependency heaviness of R packages

Gu, Z.; Huebschmann, D.

10.1101/2022.02.11.480073 — bioinformatics — Posted on 2022-02-13

2039 No leeway to enhance carbon sequestration and stock capacity via changes to forest management

Dalmonech, D.; Marano, G.; Amthor, J.; Cescatti, A.; Trotta, C.; Collalti, A.

10.1101/2022.02.10.479900 — ecology — Posted on 2022-02-13

2040 A timer gene network is spatially regulated by the terminal system in the Drosophila embryo

Clark, E.; Battistara, M.; Benton, M. A.

10.1101/2022.01.26.477848 — developmental biology — Posted on 2022-02-13

2041 Structured random receptive fields enable informative sensory encodings

Pandey, B.; Pachitariu, M.; Brunton, B. W.; Harris, K. D.

10.1101/2021.09.09.459651 — neuroscience — Posted on 2022-02-13

2042 The evolution and biological correlates of hand preferences in anthropoid primates

Caspar, K. R.; Pallasdies, F.; Mader, L.; Sartorelli, H.; Begall, S.

10.1101/2021.12.30.474462 — animal behavior and cognition — Posted on 2022-02-13

2043 Completion of neural crest cell production and emigration is regulated by retinoic acid-dependent inhibition of BMP signaling

Rekler, D.; Kalcheim, C.

10.1101/2021.08.02.454731 — developmental biology — Posted on 2022-02-13

2044 A force-balance model for centrosome positioning and spindle elongation during Interphase and Anaphase B

Paul, R.; Sarkar, A.; Mallick, A.

10.1101/2021.10.04.463000 — biophysics — Posted on 2022-02-13

2045 Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

Xu, J.; Kumar, S.; Hua, N.; Kou, Y.; Lei, X.; Rout, M.; Aitchison, J.; Alber, F.; Chen, L.

10.1101/2022.02.03.478915 — genomics — Posted on 2022-02-12

2046 Network architecture determines vein fate during spontaneous reorganization, with a time delay

Marbach, S.; Ziethen, N.; Bastin, L.; Baeuerle, F.; Alim, K.

10.1101/2021.12.29.474405 — biophysics — Posted on 2022-02-12

2047 Optogenetic dissection of actomyosin-dependent mechanics underlying tissue fluidity

Herrera-Perez, R. M.; Cupo, C.; Allan, C.; Dagle, A. B.; Kasza, K. E.

10.1101/2021.11.07.467642 — developmental biology — Posted on 2022-02-12

2048 Keystone species determine the productivity of synthetic microbial biofilm communities

Sun, X.; Xie, J.; Zheng, D.; Wang, W.; Xia, R.; Zhang, R.; Kovacs, A. T.; Xu, Z.; Shen, Q.

10.1101/2022.01.23.477386 — microbiology — Posted on 2022-02-12

2049 Expectations boost the reconstruction of auditory features from electrophysiological responses to noisy speech

Corcoran, A. W.; Perera, R.; Koroma, M.; Kouider, S.; Hohwy, J.; Andrillon, T.

10.1101/2021.09.06.459160 — neuroscience — Posted on 2022-02-12

2050 Minimal requirements for a neuron to co-regulate many properties and the implications for ion channel correlations and robustness

Yang, J.; Shakil, H.; Ratte, S.; Prescott, S. A.

10.1101/2020.12.04.410787 — neuroscience — Posted on 2022-02-12

2051 The cost of attentional reorienting on conscious visual perception: an MEG study

Spagna, A.; Bayle, D. J.; Romeo, Z.; Seidel Malkinson, T.; Liu, J.; Yahia-Cherif, L.; Chica, A. B.; Bartolomeo, P.

10.1101/2020.12.05.413161 — neuroscience — Posted on 2022-02-12

2052 Ig-VAE: Generative Modeling of Immunoglobulin Proteins by Direct 3D Coordinate Generation

Eguchi, R. R.; Choe, C. A.; Huang, P.-S.

10.1101/2020.08.07.242347 — bioinformatics — Posted on 2022-02-12

2053 Stochastic dynamics of social patch foraging decisions

Bidari, S.; El Hady, A.; Davidson, J.; Kilpatrick, Z. P.

10.1101/2022.02.11.480050 — animal behavior and cognition — Posted on 2022-02-12

2054 Plcg2M28L interacts with high fat-high sugar diet to accelerate Alzheimers disease-relevant phenotypes in mice

Oblak, A.; Kotredes, K. P.; Pandey, R. J.; Reagan, A. J.; Ingraham, C.; Perkins, B. J.; Lloyd, C.; Baker, D.; Lin, P. B.; Soni, D. M.; Tsai, A. P.; Persohn, S. C.; Bedwell, A.; Eldridge, K.; Speedy, R.; Meyer, J. L.; Peters, J. L.; Figueiredo, L.; Sasner, M. J.; Territo, P. R.; Sukoff Rizzo, S. J.; Carter, G. W.; Lamb, B. T.; Howell, G. R.

10.1101/2022.02.11.480032 — neuroscience — Posted on 2022-02-12

2055 Micro and Nanoplastics Interactions with Plant Species Trends, Meta-Analysis, and Perspectives

Azeem, I.; Adeel, M.; Ahmad, M. A.; Shakoor, N.; Zain, M.; Yousef, N.; Yinghai, Z.; Azeem, K.; Zhou, P.; White, J. C.; Yukui, R.

10.1101/2022.02.11.480069 — plant biology — Posted on 2022-02-12

2056 ERK1/2 is an ancestral organising signal in spiral cleavage

Seudre, O.; Carrillo-Baltodano, A. M.; Liang, Y.; Martin-Duran, J. M.

10.1101/2021.05.26.445819 — developmental biology — Posted on 2022-02-12

2057 Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

Overhoff, M.; Tellkamp, F.; Hess, S.; Tutas, J.; Tolve, M.; Faerfers, M.; Ickert, L.; Mohammadi, M.; De Bruyckere, E.; Kallergi, E.; Delle Vedove, A.; Nikoletopoulou, V.; Wirth, B.; Isensee, J.; Hucho, T.; Puchkov, D.; Isbrandt, D.; Krueger, M.; Kloppenburg, P.; Kononenko, N.

10.1101/2022.02.11.480034 — neuroscience — Posted on 2022-02-12

2058 Periodic attention operates faster during more complex visual search

Merholz, G.; Grabot, L.; VanRullen, R.; Dugue, L.

10.1101/2021.09.22.460906 — neuroscience — Posted on 2022-02-12

2059 Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

Kar, M.; Dar, F.; Welsh, T. J.; Vogel, L.; Kuhnemuth, R.; Majumdar, A.; Krainer, G.; Franzmann, T. M.; Alberti, S.; Seidel, C. A. M.; Knowles, T.; Hyman, A. A.; Pappu, R. V.

10.1101/2022.02.03.478969 — biophysics — Posted on 2022-02-12

2060 In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.

Checkmahomed, L.; Du Pont, V.; Riola, N. C.; Perry, J.; Li, J.; Porter, D. P.; Boivin, G.

10.1101/2022.02.07.479493 — microbiology — Posted on 2022-02-12

2061 Microbial turnover and dispersal events occur in sync with plant phenology in the perennial evergreen tree crop, Citrus sinensis

Ginnan, N.; De Anda, N. I.; Campos Freitas Vieira, F.; Rolshausen, P.; Roper, M. C.

10.1101/2022.02.10.480024 — microbiology — Posted on 2022-02-12

2062 Ecological Observations Based on Functional Gene Sequencing Are Sensitive to the Amplicon Processing Method

Cholet, F.; Lisik, A.; Agogue, H.; Zeeshan Ijaz, U.; Pineau, P.; Lachaussee, N.; Smith, C. J.

10.1101/2022.02.10.480020 — bioinformatics — Posted on 2022-02-12

2063 Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

Giulieri, S. G.; Guerillot, R.; Duchene, S.; Hachani, A.; Daniel, D.; Seemann, T.; Davis, J. S.; Tong, S. Y.; Young, B. C.; Wilson, D. J.; Stinear, T. P.; Howden, B. P.

10.1101/2022.02.11.480068 — genomics — Posted on 2022-02-12

2064 Phosphorylation by casein kinase 2 ensures ER-phagy receptor TEX264 binding to ATG8 proteins

Chino, H.; Yamasaki, A.; Ode, K. L.; Ueda, H. R.; Noda, N. N.; Mizushima, N.

10.1101/2022.02.11.480038 — cell biology — Posted on 2022-02-12

2065 SmdA is a novel cell morphology determinant in Staphylococcus aureus

Myrbraten, I. S.; Stamsas, G. A.; Chan, H.; Morales Angeles, D.; Knutsen, T. M.; Salehian, Z.; Shapaval, V.; Straume, D.; Kjos, M.

10.1101/2021.11.23.469651 — microbiology — Posted on 2022-02-12

2066 Neural Mechanism of Hunger Gated Food-seeking and evaluating

Lee, Y.; Kim, Y. B.; Kim, K. S.; Song, H. Y.; Jang, M.; Ha, D.-S.; Park, J. S.; Jung, S.-H.; Lee, J.; Kim, K. M.; Cheon, D.-H.; Baek, I.; Shin, M.-G.; Lee, E. J.; Kim, S. J.; Choi, H. J.

10.1101/2020.10.23.352187 — neuroscience — Posted on 2022-02-12

2067 Increased academic performance and prolonged career duration among Taiwanese academic faculty in ecology and evolutionary biology

Hsu, G.-C.; Lin, W.-J.; Sun, S.-J.

10.1101/2022.01.31.478501 — scientific communication and education — Posted on 2022-02-12

2068 Adaptive scans allow targeted cell-ablations on curved cell sheets

Meng, H.; Nuzhdin, D.; Sison, M.; Galland, F.; le goff, l.

10.1101/2022.01.30.478374 — biophysics — Posted on 2022-02-12

2069 Goitered Gazelle's (Gazella Subgutturosa) Habitat Desirability Modeling by Using Maximum Entropy (Maxent) Method

Naqibzadeh, A.; Sarhangzadeh, J.; Sotoudeh, A.; Mashkour, M.; Thomalsky, J.

10.1101/2022.02.10.479956 — ecology — Posted on 2022-02-12

2070 Active feature selection discovers minimal gene sets for classifying cell types and disease states with single-cell mRNA-seq data

Chen, X.; Chen, S.; Thomson, M.

10.1101/2021.06.15.448478 — bioinformatics — Posted on 2022-02-12

2071 ClonoCluster: a method for using clonal origin to inform transcriptome clustering

Richman, L. P.; Goyal, Y.; Jiang, C. L.; Raj, A.

10.1101/2022.02.11.480077 — bioinformatics — Posted on 2022-02-11

2072 Allele Dispersion Score: Quantifying the range of allele frequencies across populations, based on UMAP

Correard, S.; Arbour, L.; Wasserman, W. W.

10.1101/2022.02.11.479970 — genomics — Posted on 2022-02-11

2073 Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes

Bochynska, A.; Stenzel, A. T.; Sayadi Boroujeni, R.; Kuo, C.-C.; Barsoum, M.; Liang, W.; Bussmann, P.; Costa, I. G.; Luscher-Firzlaff, J.; Luscher, B.

10.1101/2022.02.11.480149 — cell biology — Posted on 2022-02-11

2074 Interaction of Fungal lipase with potential phytotherapeutics

Naz, F.; Khan, I.; Islam, A.; Khan, L. A.

10.1101/2022.02.11.480159 — biophysics — Posted on 2022-02-11

2075 Population genetic structure of the maize weevil, Sitophilus zeamais, in southern Mexico

Baltzegar, J. F.; Jones, M. S.; Willcox, M.; Ramsey, J. M.; Gould, F.

10.1101/2022.02.11.480163 — genetics — Posted on 2022-02-11

2076 Cell cycle and developmental control of cortical excitability in Xenopus laevis

Swider, Z. T.; Michaud, A.; Leda, M.; Landino, J.; Goryachev, A. B.; Bement, W. M.

10.1101/2022.02.11.480124 — cell biology — Posted on 2022-02-11

2077 Modulating neutrophils leads to changes in CNS output

Coulibaly, A. P.; Salken, I.; Provencio, J. J. P.

10.1101/2022.02.10.479966 — neuroscience — Posted on 2022-02-11

2078 bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors in Arabidopsis

Li, Y.; Lei, R.; Pu, M.; Cai, Y.; Lu, C.; Li, Z.; Liang, G.

10.1101/2020.04.09.035097 — plant biology — Posted on 2022-02-11

2079 The BioImage Archive - building a home for life-sciences microscopy data

Hartley, M.; Kleywegt, G.; Patwardhan, A.; Sarkans, U.; Swedlow, J. R.; Brazma, A.

10.1101/2021.12.17.473169 — bioinformatics — Posted on 2022-02-11

2080 Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants

Liu, X.; Pimm, M. L.; Haarer, B.; Brawner, A. T.; Henty-Ridilla, J. L.

10.1101/2022.01.05.475096 — biochemistry — Posted on 2022-02-11

2081 Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba

Pettie, N.; Llopart, A.; Comeron, J.

10.1101/2022.02.10.479767 — genetics — Posted on 2022-02-11

2082 Volatile social environments can favour investments in quality over quantity of social relationships

Aubier, T. G.; Kokko, H.

10.1101/2021.10.01.462760 — evolutionary biology — Posted on 2022-02-11

2083 Goitered Gazelle's (Gazella Subgutturosa) Habitat Desirability Modeling by Using Maximum Entropy (Maxent) Method

Naqibzadeh, A.; Sarhangzadeh, J.; Sotoudeh, A.; Mashkour, M.; Thomalsky, J.

10.1101/2022.02.10.479956 — ecology — Posted on 2022-02-11

2084 An in vivo model of echovirus-induced meningitis in neonates

Wells, A. I.; Coyne, C. B.

10.1101/2022.02.11.480094 — microbiology — Posted on 2022-02-11

2085 Hierarchical Computational Anatomy: Unifying the Molecular to Tissue Continuum via Measure Representations of the Brain

Miller, M. I.; Tward, D. J.; Trouve, A.

10.1101/2021.04.19.440540 — neuroscience — Posted on 2022-02-11

2086 Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner

Beiter, R. M.; Ennerfelt, H. E.; Rivet-Noor, C.; Merchak, A.; Bai, R.; Johanson, D.; Slogar, E.; Sol-Church, K.; Phillips, J.; Bathe, T.; overall, c. c.; Lukens, J. R.; Prokop, S.; Gaultier, A.

10.1101/2020.03.06.981373 — neuroscience — Posted on 2022-02-11

2087 Enhanced non-ionotropic NMDA receptor signaling drives destabilization of dendritic spines in a mouse model for studying schizophrenia

Park, D. K.; Petshow, S.; Anisimova, M.; Barragan, E. V.; Gray, J. A.; Stein, I. S.; Zito, K.

10.1101/2021.03.04.434016 — neuroscience — Posted on 2022-02-11

2088 The Resting-State Causal Human Connectome is Characterized by Hub Connectivity of Executive and Attentional Networks

Rawls, E.; Kummerfeld, E.; Mueller, B. A.; Ma, S.; Zilverstand, A.

10.1101/2021.10.20.465211 — neuroscience — Posted on 2022-02-11

2089 Evolutionary trade-offs in osmotic and ionic regulation and the expression of gill ion transporter genes in high latitude, Neotropical cold clime crabs from the 'end of the world'

McNamara, J. C.; Maraschi, A. C.; Tapella, F.; Romero, M. C.

10.1101/2022.02.11.480083 — physiology — Posted on 2022-02-11

2090 Daily running enhances molecular and physiological circadian rhythms in skeletal muscle

Casanova Vallve, N.; Duglan, D.; Vaughan, M. E.; Handzlik, M. K.; Fan, W.; Yu, R.; Liddle, C.; Downes, M.; Delezie, J.; Mello, R.; Chan, A. B.; Pariollaud, M.; Westermark, P.; Metallo, C.; Evans, R.; Lamia, K. A.

10.1101/2020.10.19.346015 — physiology — Posted on 2022-02-11

2091 ATAC-Seq and RNA-Seq combined analysis elucidates the impact of BORIS/CTCFL on melanoma progression, mediated by chromatin accessibility and gene expression alterations

Moscona, R.; Janssen, S.; Elchebly, M.; Papadakis, A.; Spatz, A.; Rubin, E.

10.1101/2022.02.11.479460 — cancer biology — Posted on 2022-02-11

2092 Cellular forces during early spreading of T lymphocytes on ultra-soft substrates

Mustapha, F.; Pelicot-Biarnes, M.; Torro, R.; Sengupta, K.; Puech, P.-H.

10.1101/2022.02.11.480084 — biophysics — Posted on 2022-02-11

2093 MIAMI: Mutual Information-based Analysis of Multiplex Imaging data

Seal, S.; Ghosh, D.

10.1101/2022.02.10.479967 — bioinformatics — Posted on 2022-02-11

2094 Local extensional flows promote long-range fiber alignment in 3D collagen hydrogels

Ahmed, A.; Joshi, I. M.; Mansouri, M.; Byerley, A. M.; Day, S. W.; Gaborski, T. R.; Abhyankar, V. V.

10.1101/2022.02.04.479166 — bioengineering — Posted on 2022-02-11

2095 Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity

Nocedal, I.; Laub, M. T.

10.1101/2022.02.11.480122 — evolutionary biology — Posted on 2022-02-11

2096 Comparative genomics of Staphylococcus capitis reveals determinants of speciation

Chong, C. E.; Bengtsson, R. J.; Horsburgh, M. J.

10.1101/2022.02.11.480064 — microbiology — Posted on 2022-02-11

2097 Exponential magnetophoretic gradient for the direct isolation of basophils from whole blood in a microfluidic system

Castano, N.; Kim, S.; Martin, A. M.; Galli, S. J.; Nadeau, K. C.; Tang, S. K. Y.

10.1101/2022.02.11.480005 — immunology — Posted on 2022-02-11

2098 STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

Masle-Farquhar, E.; Jackson, K. J. L.; Peters, T. J.; Al-Eryani, G.; Singh, M.; Payne, K. J.; Rao, G.; Apps, G.; Kingham, J.; Jara, C. J.; Skvortsova, K.; Swarbrick, A.; Ma, C.; Suan, D.; Uzel, G.; Chua, I.; Leiding, J. W.; Heiskanen, K.; Preece, K.; Kainulainen, L.; O'Sullivan, M.; Cooper, M. A.; Seppänen, M. R. J.; Mustjoki, S.; Brothers, S.; Vogel, T. P.; Brink, R.; Tangye, S. G.; Reed, J. H.; Goodnow, C. C.

10.1101/2022.02.11.480027 — immunology — Posted on 2022-02-11

2099 A single-cell resolution gene expression atlas of the larval zebrafish brain

Shainer, I.; Kuehn, E.; Laurell, E.; Al Kassar, M.; Mokayes, N.; Sherman, S.; Larsch, J.; Kunst, M.; Baier, H.

10.1101/2022.02.11.479024 — neuroscience — Posted on 2022-02-11

2100 Rearing environment persistently modulates the phenotype of mice

Jaric, I.; Voelkl, B.; Clerc, M.; Schmid, M. W.; Novak, J.; Rosso, M.; Rufener, R.; von Kortzfleisch, V.; Richter, H. S.; Buettner, M.; Bleich, A.; Amrein, I.; Wolfer, D. P.; Touma, C.; Sunagawa, S.; Wuerbel, H.

10.1101/2022.02.11.480070 — neuroscience — Posted on 2022-02-11

2101 Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

Overhoff, M.; Tellkamp, F.; Hess, S.; Tutas, J.; Tolve, M.; Faerfers, M.; Ickert, L.; Mohammadi, M.; De Bruyckere, E.; Kallergi, E.; Dekk Vedove, A.; Nikoletopoulou, V.; Wirth, B.; Isensee, J.; Hucho, T.; Puchkov, D.; Isbrandt, D.; Krueger, M.; Kloppenburg, P.; Kononenko, N.

10.1101/2022.02.11.480034 — neuroscience — Posted on 2022-02-11

2102 Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion in rats

Sydney-Smith, J. D.; Koltchev, A. M.; Moon, L. D. F.; Warren, P. M.

10.1101/2022.02.11.479866 — neuroscience — Posted on 2022-02-11

2103 Extensive in vitro and in vivo protein translation via in situ circularized RNAs

Kumar, A.; Palmer, N.; Miyasaki, K.; Finburgh, E.; Xiang, Y.; Portell, A.; Dailamy, A.; Suhardjo, A.; Chew, W. L.; Kwon, E. J.; Mali, P.

10.1101/2022.02.11.480072 — bioengineering — Posted on 2022-02-11

2104 Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

Liu, T.; Shilliday, F.; Cook, A. D.; Tewari, R.; Sutherland, C. J.; Roberts, A. J.; Moores, C. A.

10.1101/2022.02.11.480087 — biochemistry — Posted on 2022-02-11

2105 Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

Bous, J.; Fouillen, A.; Orcel, H.; Trapani, S.; Cong, X.; Fontanel, S.; Saint-Paul, J.; LAI KEE HIM, J.; Urbach, S.; Sibille, N.; SOUNIER, R.; Granier, S.; Mouillac, B.; Bron, P.

10.1101/2022.02.11.480047 — biochemistry — Posted on 2022-02-11

2106 Whole genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

Mouri, K.; Dewey, H. B.; Castro, R.; Berenzy, D.; Kales, S.; Tewhey, R.

10.1101/2022.02.11.479757 — genomics — Posted on 2022-02-11

2107 Whole-Genome Sequencing and Comparative Genomic Analysis of Potential Biotechnological Strains from Trichoderma harzianum, Trichoderma atroviride, and Trichoderma reesei

Rosolen, R. R.; Horta, M. A. C.; de Azevedo, P. H. C.; da Silva, C. C.; Sforca, D. A.; Goldman, G. H.; de Souza, A. P.

10.1101/2022.02.11.479986 — genomics — Posted on 2022-02-11

2108 The nature and chromosomal landscape of endogenous retroviruses (ERVs) integrated in the sheep nuclear genome

Mustafa, S. I.; Schwarzachera, T.; Heslop-Harrison, J.

10.1101/2022.02.11.480048 — genomics — Posted on 2022-02-11

2109 Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

Sump, B.; Brickner, D. G.; D'Urso, A.; Kim, S. H.; Brickner, J. H.

10.1101/2022.02.11.480054 — genetics — Posted on 2022-02-11

2110 Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling

Wang, Z.; Xia, X.; Igaki, T.

10.1101/2022.02.11.480121 — cell biology — Posted on 2022-02-11

2111 RpoN is required for a functional type III secretion system in Yersinia pseudotuberculosis

Mahmud, A. K. M. F.; Navais, R.; Nilsson, K.; Choudhury, R.; Avican, K.; Fallman, M.

10.1101/2022.02.11.480049 — molecular biology — Posted on 2022-02-11

2112 Local structural dynamics of alpha-synuclein correlate with aggregation in different physiological conditions

Seetaloo, N.; Zacharopoulou, M.; Stephens, A. D.; Kaminski Schierle, G. S.; Phillips, J. J.

10.1101/2022.02.11.480045 — molecular biology — Posted on 2022-02-11

2113 Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life

Bhattacharya, K.; Maiti, S.; Zahoran, S.; Weidenauer, L.; Hany, D.; Wider, D.; Bernasconi, L.; Quadroni, M.; Collart, M.; Picard, D.

10.1101/2022.02.11.480086 — molecular biology — Posted on 2022-02-11

2114 Two bridgehead invasions of Xylella fastidiosa subsp. multiplex in France

Dupas, E.; Durand, K.; Rieux, A.; Briand, M.; Pruvost, O.; Cunty, A.; Denance, N.; Donnadieu, C.; Legendre, B.; Lopez-Roques, C.; Cesbron, S.; Ravigne, V.; Jacques, M.-A.

10.1101/2022.02.11.480026 — microbiology — Posted on 2022-02-11

2115 Vagal involvement in non-dipping phenotype of Hsd11b2 knockout rats

Mullins, L. J.; Koutraki, Y. G. S.; Bailey, M. A.; Mullins, J. J.

10.1101/2022.02.11.480066 — physiology — Posted on 2022-02-11

2116 Predictive link between systemic metabolism and immune signaling in the brain of APOE4 mice

Fleeman, R. M.; Snyder, A. M.; Kuhn, M. K.; Chan, D. C.; Arnold, A. C.; Proctor, E. A.

10.1101/2022.02.11.480074 — physiology — Posted on 2022-02-11

2117 Antisense oligonucleotides targeting exon 11 are able to partially rescue the Neurofibromatosis Type 2 phenotype in vitro

Catasus, N.; Rosas, I.; Bonache, S.; Negro, A.; Plana, A.; Salvador, H.; Serra, E.; Blanco, I.; CASTELLANOS, E.

10.1101/2022.02.11.479859 — genetics — Posted on 2022-02-11

2118 Having the 'right' microbiome matters for host trait expression and the strength of mutualism between duckweeds and microbes

O'Brien, A.; Laurich, J.; Frederickson, M. E.

10.1101/2022.02.10.479958 — evolutionary biology — Posted on 2022-02-11

2119 Low-cost sample preservation methods for high-throughput processing of rumen microbiomes

Budel, J. C. C.; Hess, M. K.; Bilton, T. P.; Henry, H.; Dodds, K. G.; Janssen, P. H.; McEwan, J. C.; Rowe, S. J.

10.1101/2022.02.10.480010 — microbiology — Posted on 2022-02-11

2120 Optimal routing to cerebellum-like structures

Muscinelli, S.; Wagner, M.; Litwin-Kumar, A.

10.1101/2022.02.10.480014 — neuroscience — Posted on 2022-02-11

2121 Rapid design and prototyping of biocatalytic virus-like particle nanoreactors

Esquirol, L.; McNeale, D.; Douglas, T.; Vickers, C. E.; Sainsbury, F.

10.1101/2022.02.10.479872 — synthetic biology — Posted on 2022-02-11

2122 Sequence- and chemical specificity define the functional landscape of intrinsically disordered regions

Langstein-Skora, I.; Schmid, A.; Emenecker, R. J.; Richardson, M. O. G.; Goetz, M. J.; Payer, S. K.; Korber, P.; Holehouse, A. S.

10.1101/2022.02.10.480018 — biophysics — Posted on 2022-02-11

2123 A network-based drug repurposing approach identifies new treatment opportunities for the systemic chronic inflammation underlying multiple complex diseases

Hickey, S. L.; McKim, A.; Mancuso, C. A.; Krishnan, A.

10.1101/2022.02.10.479987 — bioinformatics — Posted on 2022-02-11

2124 First whole-genome sequence of Cervid atadenovirus A outside of the United States from an Adenoviral hemorrhagic disease epizootic of black-tailed deer in Canada

Lung, O.; Fisher, M.; Nebroski, M.; McGregor, G.; Schwantje, H.; Joseph, T.

10.1101/2022.02.10.479879 — genomics — Posted on 2022-02-11

2125 Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies

Lu, Z.; Gopalan, S.; Yuan, D.; Conti, D. V.; Pasaniuc, B.; Gusev, A.; Mancuso, N.

10.1101/2022.02.10.479993 — genetics — Posted on 2022-02-11

2126 Seeing the future: a better way to model and test for adaptive developmental plasticity

Malani, A.; Rosenbaum, S.; Alberts, S. C.; Archie, E.

10.1101/2022.02.10.479998 — evolutionary biology — Posted on 2022-02-11

2127 Spatial patterns from a dispersal limitation perspective: revealing biotic interactions

Kalyuzhny, M.; Lake, J. K.; Ostling, A. M.

10.1101/2022.02.10.480007 — ecology — Posted on 2022-02-11

2128 How nutrition and energy needs affect bumble beepollination services: A mathematical model

Capera-Aragones, P.; Tyson, R.; Foxall, E.

10.1101/2022.02.10.480001 — ecology — Posted on 2022-02-11

2129 Functional assessment of the ionotropic receptors IR25a and IR93a in predator perception in the freshwater crustacean Daphnia using RNA interference

Graeve, A.; Huster, J.; Mayweg, J.; Fiedler, R.; Plassmann, J.; Wahle, P.; Weiss, L. C.

10.1101/2022.02.11.480022 — ecology — Posted on 2022-02-11

2130 HIV, Pathology and epigenetic age acceleration in different human tissues

Horvath, S.; Lin, D. T.; Kobor, M. S.; Said, J. W.; Morgello, S.; Singer, E.; Yong, W. H.; Jamieson, B. D.; Levine, A. J.

10.1101/2022.02.10.480013 — molecular biology — Posted on 2022-02-11

2131 The First Inhibitor of Meso-Diaminopimelate Biosynthesis with Antibacterial Activity Against Multi-Drug Resistant Bacteria

Soares da Costa, T. P.; Wyllie, J. A.; Ghardi, C. K.; Hulett, M. D.; Abbott, B. M.; Sutton, M.; Perugini, M. A.

10.1101/2022.02.10.480023 — microbiology — Posted on 2022-02-11

2132 Compartmental Neuropeptide Release Measured Using a New Oxytocin Sensor

Qian, T.; Wang, H.; Wang, P.; Geng, L.; Mei, L.; Osakada, T.; Tang, Y.; Kania, A.; Grinevich, V.; Stoop, R.; Lin, D.; Luo, M.; Li, Y.

10.1101/2022.02.10.480016 — neuroscience — Posted on 2022-02-11

2133 Restriction of dietary protein in rats increases progressive-ratio motivation for protein

Chiacchierini, G.; Naneix, F.; Apergis-Schoute, J.; McCutcheon, J. E.

10.1101/2022.02.10.479961 — neuroscience — Posted on 2022-02-11

2134 Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis

Mukhtar, T.; Breda, J.; Boareto, M.; Grobecker, P.; Karimaddini, Z.; Grison, A.; Eschbach, K.; Chandrasekhar, R.; Vermeul, S.; Okoniewski, M.; Pachkov, M.; Atanasoski, S.; Beisel, C.; Iber, D.; Nimwegen, E. v.; Taylor, V.

10.1101/2022.02.10.479992 — neuroscience — Posted on 2022-02-11

2135 TP53 knockout in MCF7 breast cancer cells induces sensitivity to fluoropyrimidine drugs.

Warrington, J. M.; Mehta, S.; Moy, V. F.; Patel, J.; Liu, C.; Rago, A.; McTighe, C.; Delgado, I.; Banister, C.; Gmeiner, W.; Buckhaults, P. J.

10.1101/2022.02.10.479997 — cancer biology — Posted on 2022-02-11

2136 Aspirin synergizes with regorafenib to reduce growth of colorectal cancer

Su, C.; Fennell, L. J.; Bond, C. E.; Kane, A. M.; Kerr, G.; Jarde, T.; Micati, D.; Engel, R. M.; Chan, W. H.; Hlavca, S.; Archer, S.; McMurrick, P. J.; Hammerlindl, H.; Lim, F.; Salik, B.; McKeone, D. M.; Hartel, G.; Borowsky, J.; Ladwa, R.; Leggett, B. A.; Schaider, H.; Abud, H. E.; Boyle, G. M.; Burge, M. E.; Whitehall, V. L.

10.1101/2022.02.11.480021 — cancer biology — Posted on 2022-02-11

2137 Sequence-dependent mechanochemical coupling of helicase translocation and unwinding at single-nucleotide resolution.

Laszlo, A. H.; Craig, J. M.; Gavrilov, M.; Tippana, R.; Nova, I. C.; Huang, J. R.; Kim, H. C.; Abell, S. J.; deCampos-Stairiker, M.; Mount, J. W.; Bowman, J. L.; Baker, K. S.; Higinbotham, H.; Bobrovnikov, D.; Ha, T.; Gundlach, J. H.

10.1101/2022.02.10.479955 — biophysics — Posted on 2022-02-11

2138 Barrier-free liquid condensates of nanocatalysts as effective concentrators of catalysis

BEDI, S.; Kumar, G.; ROSE, S. M.; RAKSHIT, S.; Sinha, S.

10.1101/2022.02.10.480015 — biophysics — Posted on 2022-02-11

2139 Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane

Xia, X.; Liu, S.; Zhou, H.

10.1101/2022.02.10.480008 — biophysics — Posted on 2022-02-11

2140 MIAMI: Mutual Information-based Analysis of Multiplex Imaging data

Seal, S.; Ghosh, D.

10.1101/2022.02.10.479967 — bioinformatics — Posted on 2022-02-11

2141 polishCLR: a Nextflow workflow for polishing PacBio CLR genome assemblies

Chang, J.; Stahlke, A. R.; Chudalayandi, S.; Rosen, B. D.; Childers, A. K.; Severin, A.

10.1101/2022.02.10.480011 — bioinformatics — Posted on 2022-02-11

2142 CaSee: A lightning transfer-learning model directly used to discriminate cancer/normal cells from scRNA-seq

Sh, Y.; Zhang, X.; Guo, C.; Shi, F.; Jia, F.; Hu, Z.

10.1101/2022.02.10.480003 — bioinformatics — Posted on 2022-02-11

2143 Photolabile curcumin with physically and molecularly produced light for attenuating of neurotoxicity of amyloid beta species

Kuang, S.; Zhu, B.; Zhang, J.; Yang, F.; Wu, B.; Ran, C.

10.1101/2022.02.10.478818 — biochemistry — Posted on 2022-02-11

2144 DISSECTING LIGHT SENSING AND METABOLIC PATHWAYS ON THE MILLIMETER SCALE IN HIGH-ALTITUDE MODERN STROMATOLITES

Alonso-Reyes, D. G.; Galvan, S.; Irazoqui, J. M.; Amadio, A.; Tschoeke, D.; Thompson, F. L.; Albarracin, V. H.; Farias, M. E.

10.1101/2022.02.10.479979 — ecology — Posted on 2022-02-11

2145 Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

Sargsian, S.; Chen, Z.; Lee, S. C.; Robertson, A.; Sproch, J.; Devlin, J. C.; Tee, M. Z.; Er, Y. X.; Copin, R.; Heguy, A.; Pironti, A.; Torres, V. J.; Ruggles, K. V.; Lim, Y. A. L.; Loke, P.; Cadwell, K.

10.1101/2022.02.10.479991 — microbiology — Posted on 2022-02-11

2146 RNA polymerase redistribution and increased gene dosage support growth in E. coli strains with a minimal number of ribosomal RNA operons

Fan, J.; El Sayyed, H.; Pambos, O. J.; Stracy, M.; Kyropoulos, J.; Kapanidis, A. N.

10.1101/2022.02.10.479894 — microbiology — Posted on 2022-02-11

2147 Operational tolerance is early acquired and long maintained in 50% liver allograft transplantation

Zhou, S.

10.1101/2022.02.10.480000 — immunology — Posted on 2022-02-11

2148 Aging and white matter microstructure and macrostructure: a longitudinal multi-site diffusion MRI study of 1,184 participants

Schilling, K.; Archer, D. B.; Yeh, F.-C.; Rheault, F.; Cai, L. Y.; Hansen, C. B.; Yang, Q.; Ramadass, K.; Shafer, A.; Resnick, S.; Pechman, K. R.; Gifford, K. A.; Hohman, T. J.; Jefferson, A.; Anderson, A. W.; Kang, H.; Landman, B. A.

10.1101/2022.02.10.479977 — neuroscience — Posted on 2022-02-11

2149 Non-invasive stimulation with Temporal Interference: Optimization of the electric field deep in the brain with the use of a genetic algorithm

Stoupis, D.; Samaras, T.

10.1101/2022.02.10.477970 — neuroscience — Posted on 2022-02-11

2150 Duration reproduction under memory pressure: Modeling the roles of visual memory load in duration encoding and reproduction

Zang, X.; Zhu, X.; Allenmark, F.; Wu, J.; Müller, H. J.; Glasauer, S.; Shi, Z.

10.1101/2022.02.10.479853 — neuroscience — Posted on 2022-02-11

2151 PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Foley, K.; Altimimi, H.; Hou, H.; Zhang, Y.; McKee, C.; Papasergi-Scott, M. M.; Yang, H.; Mayer, A.; Ward, N.; MacLean, D. M.; Nairn, A. C.; Stellwagen, D.; Xia, H.

10.1101/2022.02.10.480004 — neuroscience — Posted on 2022-02-11

2152 Profiling of the most reliable mutations from sequenced SARS-CoV-2 genomes scattered in Uzbekistan

Ayubov, M. S.; Buriev, Z. T.; Mirzakhmedov, M. K.; Yusupov, A. N.; Usmanov, D. E.; Shermatov, S. E.; Ubaydullaeva, K. A.; Abdurakhmonov, I.

10.1101/2022.02.10.479714 — genomics — Posted on 2022-02-11

2153 Genetic and microbial diversity of the invasive mosquito vector species Culex tritaeniorhynchus across its extensive inter-continental geographic range

Jeffries, C. L.; Tantely, L. M.; Kadriaj, P.; Blagrove, M. S. C.; Lytra, I.; Orsborne, J.; Al-Amin, H. M.; Mohammed, A. R.; Alam, M. S. S. C.; Girod, R.; Afrane, Y. A.; Bino, S.; Robert, V.; Boyer, S.; Baylis, M.; Velo, E.; Hughes, G. L.; Walker, T.

10.1101/2022.02.10.479990 — genetics — Posted on 2022-02-11

2154 Predicting Math Ability using Working Memory, Number Sense, and Neurophysiology in Children and Adults

van Bueren, N. E. R.; van der Ven, S. H. G.; Roelofs, K.; Cohen Kadosh, R.; Kroesbergen, E. H.

10.1101/2022.02.10.479865 — neuroscience — Posted on 2022-02-11

2155 Increased prevalence of a frontoparietal brain state at rest is associated with better motor recovery in individuals with pontine stroke affecting dominant-hand corticospinal tract

Olafson, E.; Russello, G.; Jamison, K. W.; Liu, H.; Wang, D.; Bruss, J.; Boes, A.; Kuceyeski, A.

10.1101/2022.02.10.479962 — neuroscience — Posted on 2022-02-11

2156 An efficient and cost-effective method for directed mutagenesis at multiple dispersed sites - a case study with Omicron Spike DNA

Rani, R.; Parsa, K. V. L.; Chatti, K. R.; Sevilimedu, A.

10.1101/2022.02.10.480017 — molecular biology — Posted on 2022-02-11

2157 Omicron (BA.1) and Sub-Variants (BA.1, BA.2 and BA.3) of SARS-CoV-2 Spike Infectivity and Pathogenicity: A Comparative Sequence and Structural-based Computational Assessment

Kumar, S.; Karuppanan, K.; Subramaniam, G.

10.1101/2022.02.11.480029 — bioinformatics — Posted on 2022-02-11

2158 Molecular Dynamics Simulations Studies On The Effects Of Mutations On The Binding Affinities Between SARS-CoV-2 Spike RBD And Human ACE2

Arora, S.; Patra, J.

10.1101/2022.02.11.480063 — bioinformatics — Posted on 2022-02-11

2159 Binding Interactions between RBD of Spike-Protein and Human ACE2 in Omicron variant

Jawad, B.; Adhikari, P.; Podgornik, R.; Ching, W.-Y.

10.1101/2022.02.10.480009 — biochemistry — Posted on 2022-02-11

2160 Privacy-Preserving Federated Neural Network Learning for Disease-Associated Cell Classification

Sav, S.; Bossuat, J.-P.; Troncoso-Pastoriza, J. R.; Claassen, M.; Hubaux, J.-P.

10.1101/2022.01.10.475610 — cell biology — Posted on 2022-02-11

2161 Musical expertise shapes visual-melodic memory integration

Hoffmann, M.; Schmidt, A.; Ploner, C. J.

10.1101/2022.02.03.478977 — neuroscience — Posted on 2022-02-11

2162 Wiring diagram of the oxytocin system in the mouse brain

Son, S.; Manjila, S. B.; Newmaster, K. T.; Wu, Y.-t.; Vanselow, D. J.; Ciarletta, M.; Anthony, T. E.; Cheng, K. C.; Kim, Y.

10.1101/2020.10.01.320978 — neuroscience — Posted on 2022-02-11

2163 An Agent-Based Model of monocyte differentiation into Tumour-Associated Macrophages in Chronic Lymphocytic Leukemia

Verstraete, N.; Marku, M.; Domagala, M.; Bordenave, J.; Arduin, H.; Fournie, J. J.; Ysebaert, L.; Poupot, M.; Pancaldi, V.

10.1101/2021.12.17.473137 — systems biology — Posted on 2022-02-11

2164 Characterization of alkaloids and metabolic intermediates from Dendrobium officinale induced by methyl jasmonate

Song, C.; Zhang, Y.; Manzoor, M. A.; Jin, Q.; Li, G.

10.1101/2022.02.09.479720 — plant biology — Posted on 2022-02-11

2165 Fusobacterium nucleatum induces pancreatic cancer cell proliferation and migration by regulating host autocrine and paracrine signaling

Udayasuryan, B.; Nguyen, T. T. D.; Umana, A.; Ahmad, R. A.; Roberts, L. M.; Sobol, P.; Jones, S. D.; Munson, J. M.; Slade, D. J.; Verbridge, S. S.

10.1101/2021.11.19.469245 — cancer biology — Posted on 2022-02-11

2166 A metric and its derived protein network for evaluation of ortholog database inconsistency

Yang, W.; Ji, J.; Ling, S.; Fang, G.

10.1101/2022.01.24.477246 — bioinformatics — Posted on 2022-02-11

2167 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

Laughlin, Z. T.; Nandi, S.; Dey, D.; Zelinskaya, N.; Witek, M. A.; Srinivas, P.; Nguyen, H. A.; Kuiper, E. G.; Comstock, L. R.; Dunham, C. M.; Conn, G. L.

10.1101/2021.11.11.467980 — biochemistry — Posted on 2022-02-11

2168 Response of soil and vegetation in a warm-temperate Pine forest to intensive biomass harvests, phosphorus fertilisation, and wood ash application.

Augusto, L.; Beaumont, F.; Nguyen, C.; Fraysse, J.-Y.; Trichet, P.; Meredieu, C.; Vidal, D.; Sappin-Didier, V.

10.1101/2021.03.16.435291 — ecology — Posted on 2022-02-11

2169 A reference induced pluripotent stem cell line for large-scale collaborative studies

Pantazis, C. B.; Yang, A.; Lara, E.; McDonough, J. A.; Blauwendraat, C.; Peng, L.; Oguro, H.; Zou, J.; Sebesta, D.; Pratt, G.; Cross, E.; Blockwick, J.; Buxton, P.; Kinner-Bibeau, L.; Medura, C.; Tompkins, C.; Hughes, S.; Santiana, M.; Faghri, F.; Nalls, M. A.; Vitale, D.; Qi, Y. A.; Ramos, D. M.; Anderson, K. M.; Stadler, J.; Narayan, P.; Papademetriou, J.; Reilly, L.; Nelson, M. P.; Aggarwal, S.; Rosen, L. U.; Kirwan, P.; Pisupati, V.; Coon, S. L.; Scholz, S. W.; Coccia, E.; Sarrafha, L.; Ahfeldt, T.; Funes, S.; Bosco, D. A.; Beccari, M. S.; Cleveland, D. W.; Zanellati, M. C.; Basundra, R.;

10.1101/2021.12.15.472643 — neuroscience — Posted on 2022-02-11

2170 Cerebellar Neuronal Dysfunction Accompanies Early Motor Symptoms in Spinocerebellar Ataxia Type 3

Palarz, K.; Neves-Carvalho, A.; Maciel, P.; Khodakhah, K.

10.1101/2021.04.29.441865 — neuroscience — Posted on 2022-02-11

2171 Interferon adjusts stem cell output in the young and old brain to meet demand independently of its antiviral function

Carvajal Ibanez, D.; Skabkin, M.; Hooli, J.; Cerrizuela, S.; Goepferich, M.; Jolly, A.; Zumwinkel, M.; Bertolini, M.; Hoefer, T.; Kramer, G.; Anders, S.; Teleman, A. A.; Marciniak-Czochra, A.; Martin-Villalba, A.

10.1101/2022.02.03.478954 — neuroscience — Posted on 2022-02-11

2172 Sucrose-dependence of sugar uptake, quorum sensing and virulence of the rice blight pathogen Xanthomonas oryzae pv. oryzae

Sadoine, M.; Long, J.; Song, C.; Arra, Y.; Frommer, W. B.; Yang, B. B.

10.1101/2021.08.22.457195 — plant biology — Posted on 2022-02-11

2173 Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of Parkinson's disease

Palese, F.; Pontis, S.; Realini, N.; Torrens, A.; Ahmed, F.; Assogna, F.; Pellicano, C.; Bossu, P.; Spalletta, G.; Green, K. N.; Piomelli, D.

10.1101/2022.02.10.479850 — pharmacology and toxicology — Posted on 2022-02-11

2174 Genetic instability from a single S-phase after whole genome duplication

Gemble, S.; Wardenaar, R.; Keuper, K.; Srivastava, N.; Nano, M.; Mace, A.-S.; Tijhuis, A.; Bernhard, S. V.; Spierings, D. C. J.; Simon, A.; Goundiam, O.; Hochegger, H.; Piel, M.; Foijer, F.; Storchova, Z.; Basto, R.

10.1101/2021.07.16.452672 — cell biology — Posted on 2022-02-11

2175 Bacteriophage-derived dsRNA exerts anti-SARS-CoV-2 activity in vitro and in Golden Syrian hamsters in vivo

Vaivode, K.; Verhovcova, I.; Skrastina, D.; Petrovska, R.; Kreismane, M.; Lapse, D.; Rubene, D.; Kalnina, Z.; Pjanova, D.

10.1101/2022.01.22.477073 — microbiology — Posted on 2022-02-11

2176 Tongue immune compartment analysis reveals spatial macrophage heterogeneity

Mildner, A.; Lyras, E. M.; Zimmermann, K.; Wagner, L. K.; Dörr, D.; Fischer, C.; Jung, S.; Yona, S.; Hovav, A.-H.; Stenzel, W.; Dommerich, S.; Conrad, T.; Leutz, A.

10.1101/2022.02.09.479699 — immunology — Posted on 2022-02-11

2177 In situ cell-surface conformation of the TCR-CD3 signaling complex

Krogsgaard, M.; Natarajan, A.; Wang, W.; Flores, M. B.; Li, T.; Shin, H. W.; Beesam, S.; Cardozo, T.

10.1101/2022.02.07.479368 — immunology — Posted on 2022-02-11

2178 Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

Ai, L.; Li, Y.; Zhou, L.; Zhang, H.; Yao, W.; Han, J.; Wu, J.; Wang, R.; Wang, W.; Xu, P.; Li, Z.; Wei, C.; Chen, H.; Liang, J.; Guo, M.; Huang, Z.; Wang, X.; Zhang, Z.; Xiang, W.; Lv, B.; Peng, P.; Zhang, S.; Ji, X.; Li, Z.; Luo, H.; Chen, J.; Lan, K.; Hu, Y.

10.1101/2022.02.10.479867 — immunology — Posted on 2022-02-11

2179 Allometric scaling of a superposition eye optimises sensitivity and acuity in large and small hawkmoths

Stöckl, A. L.; Grittner, R.; Taylor, G. J.; Rau, C.; Bodey, A. J.; Baird, E.

10.1101/2022.02.08.479593 — neuroscience — Posted on 2022-02-11

2180 Novel AlphasynucleinPAN in human Mesenchymal Stem Cells-derived neurons masks SNCA140 and creates dissociation of deleterious SNCA98 in astrocytoma stem cells

owoola, A. G.; Okolicsanyi, R. K.; Griffiths, L. R.; Haupt, L. M.

10.1101/2022.02.08.479501 — neuroscience — Posted on 2022-02-11

2181 Orchestration of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plant

Li, L.; Sun, T.; Wang, P.; Lu, S.; Yuan, H.; Yang, Y.; Fish, T.; Thannhauser, T.; Liu, J.; Mazourek, M.; Grimm, B.

10.1101/2022.02.08.479616 — plant biology — Posted on 2022-02-11

2182 Chronic Intermittent Hypobaric Hypoxia Prevents Contrast-Induced Acute Kidney Injury By Modulating The HIF-1α Signaling Pathway

Zhang, L.; Ni, Y.-h.; Cao, G.-y.; Zhang, J.-y.; Yi, B.-j.; Pang, Z.-h.; Ma, H.-j.; Yin, K.-m.

10.1101/2022.02.07.479411 — physiology — Posted on 2022-02-11

2183 Tropical land use alters functional diversity of soil food webs and leads to monopolization of the detrital energy channel

Zhou, Z.; Krashevska, V.; Widyastuti, R.; Scheu, S.; Potapov, A.

10.1101/2022.02.08.479508 — ecology — Posted on 2022-02-11

2184 A single cell atlas of the cycling murine ovary

Morris, M. E.; Meinsohn, M.-C.; Chauvin, M.; Nguyen, N.; Saatcioglu, H. D.; Yuan, S.; Kashiwagi, A.; Sicher, N. A.; Hyun, M.; Donahoe, P. K.; Sabatini, B. L.; Pepin, D.

10.1101/2022.02.08.479522 — developmental biology — Posted on 2022-02-11

2185 Improving the robustness of engineered bacteria to nutrient stress using programmed proteolysis

Szydlo, K.; Ignatova, Z.; Gorochowski, T. E.

10.1101/2021.10.04.463040 — synthetic biology — Posted on 2022-02-11

2186 Modeling Dynamic Transcriptional Circuits with CRISPRi

Clamons, S. E.; Murray, R. M.

10.1101/225318 — synthetic biology — Posted on 2022-02-11

2187 Glioblastoma exosomes influence glial cell hyaluronic acid deposition to promote invasiveness

Norman, J. C.; Koessinger, D.; Novo, D.; Birch, J.; Mitchell, L.; Moore, M.; Zerbst, D.; Chalmers, A.; Koessinger, A.; Stevenson, K.; Nielson, M.

10.1101/2022.02.11.480036 — cancer biology — Posted on 2022-02-11

2188 Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network

Bano, R.; Mears, P.; Golding, I.; Chemla, Y. R.

10.1101/2020.03.23.003962 — biophysics — Posted on 2022-02-11

2189 Sexual reproduction contributes to the evolution of resistance breaking isolates of the spinach pathogen Peronospora effusa

Skiadas, P.; Klein, J.; Quiroz Monnens, T.; Elberse, J.; de Jonge, R.; Van den Ackerveken, G.; Seidl, M. F.

10.1101/2021.11.05.467349 — evolutionary biology — Posted on 2022-02-11

2190 Timely Schwann cell division during migration drives peripheral myelination in vivo via Laminin/cAMP pathway

Mikdache, A.; Boueid, M.-J.; Lesport, E.; Delespierre, B.; Loisel-Duwattez, J.; Degerny, C.; Tawk, M.

10.1101/2022.02.11.480035 — developmental biology — Posted on 2022-02-11

2191 MOSPD2 a new endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis

ZOUIOUICH, M.; DI MATTIA, T.; MARTINET, A.; EICHLER, J.; WENDLING, C.; TOMISHIGE, N.; GRANDGIRARD, E.; FUGGETTA, N.; RAMAIN, C.; MIZZON, G.; Dumesnil, C.; CARPENTIER, M.; REINA-SAN-MARTIN, B.; MATHELIN, C.; Schwab, Y.; THIAM, A. R.; KOBAYASHI, T.; DRIN, G.; TOMASETTO, C.; ALPY, F.

10.1101/2022.02.11.479928 — cell biology — Posted on 2022-02-11

2192 Phosphorylation by casein kinase 2 ensures ER-phagy receptor TEX264 binding to ATG8 proteins

Chino, H.; Yamasaki, A.; Ode, K. L.; Ueda, H. R.; Noda, N. N.; Mizushima, N.

10.1101/2022.02.11.480038 — cell biology — Posted on 2022-02-11

2193 Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state

Kipper, K.; Mansour, A.; Pulk, A.

10.1101/2022.01.31.478155 — molecular biology — Posted on 2022-02-11

2194 Omission responses in field potentials but not spikes in rat auditory cortex

Auksztulewicz, R.; Rajendran, V. G.; Peng, F.; Schnupp, J. W. H.; Harper, N. S.

10.1101/2022.02.11.479668 — neuroscience — Posted on 2022-02-11

2195 Hebbian and homeostatic plasticity mechanisms are segregated in sub-types of layer 5 neuron in the visual cortex

Fox, K. D.; Pandey, A.; Hardingham, N. R.

10.1101/2022.02.11.480060 — neuroscience — Posted on 2022-02-11

2196 Deep-learning based identification, tracking, pose estimation, and behavior classification of interacting primates and mice in complex environments

Marks, M.; Qiuhan, J.; Sturman, O.; von Ziegler, L.; Kollmorgen, S.; von der Behrens, W.; Mante, V.; Bohacek, J.; Yanik, M. F.

10.1101/2020.10.26.355115 — neuroscience — Posted on 2022-02-11

2197 Analyses of symbiotic bacterial communities in the plant pest Bemisia tabaci reveal high prevalence of Candidatus Hemipteriphilus asiaticus on the African continent

Mouton, L.; Henri, H.; Romba, R.; Belgaidi, Z.; Gnankine, O.; Vavre, F.

10.1101/2021.10.06.463217 — evolutionary biology — Posted on 2022-02-11

2198 Causes, temporal trends and the effects of urbanisation on admissions of wild raptors to rehabilitation centres in England and Wales

Panter, C. T.; Allen, S.; Backhouse, N.; Mullineaux, E.; Rose, C.-A.; Amar, A.

10.1101/2022.02.10.479874 — ecology — Posted on 2022-02-11

2199 Prox1 dynamically regulates downstream targets and chromatin accessibility during venous to lymphatic endothelial cell transdifferentiation in the embryo

Grimm, L.; Mason, E. A.; Dudczig, S.; Kazenwadel, J.; Chen, T.; Yu, O.; Bower, N. I.; Paterson, S.; Okuda, K.; Rondon Galeano, M.; Kobayashi, S.; Senabouth, A.; Lagendijk, A.; Powell, J.; Smith, K.; Harvey, N.; Koltowska, K.; Hogan, B. M.

10.1101/2022.02.10.479999 — developmental biology — Posted on 2022-02-11

2200 Determination of protein stoichiometries via dual-color colocalization with single molecule localization microscopy

Tan, H. L.; Bungert-Plümke, S.; Kortzak, D.; Fahlke, C.; Stölting, G.

10.1101/2021.10.05.463155 — cell biology — Posted on 2022-02-11

2201 Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart

karsenty, c.; frugier, c.; GENET, G.; SEGUELAS, M.-H.; Alzieu, P.; Cazorla, O.; Montagner, A.; Blum, Y.; Dubroca, c.; Maupoint, J.; Tramunt, B.; Cauquil, M.; Sulpice, T.; Richard, S.; Arcucci, S.; Flores-Flores, R.; Pataluch, N.; Montoriol, R.; Sicard, P.; Deney, A.; Couffinhal, T.; Senard, J.-M.; Gales, C.

10.1101/2022.02.11.480042 — cell biology — Posted on 2022-02-11

2202 NICEgame: A workflow for annotating the knowledge gaps in metabolic reconstructions, using known and hypothetical reactions

Vayena, E.; Chiappino-Pepe, A.; MohammadiPeyhani, H.; Francioli, Y.; Hadadi, N.; Ataman, M.; Hafner, J.; Pavlou, S.; Hatzimanikatis, V.

10.1101/2022.02.10.479881 — systems biology — Posted on 2022-02-11

2203 Integrative small and long RNA-omics analysis of human healing and non-healing wounds discovers cooperating microRNAs as therapeutic targets

Liu, Z.; Zhang, L.; Toma, M. A.; Li, D.; Bian, X.; Pastar, I.; Tomic-Canic, M.; Sommar, P.; Xu Landen, N.

10.1101/2021.12.17.473103 — systems biology — Posted on 2022-02-11

2204 DAF-2/insulin IGF-1 receptor regulates mobility during ageing by integrating opposite inputs from muscle and neuronal tissues

Roy, C.; Molin, L.; Alcolei, A.; Solyga, M.; Bonneau, B.; Vachon, C.; Bessereau, J.-L.; Solari, F.

10.1101/2021.10.15.464514 — physiology — Posted on 2022-02-11

2205 Antennapedia and optix regulate metallic silver wing scale development and cell shape in Bicyclus anynana butterflies

Prakash, A.; Finet, C.; Banerjee, T. D.; Saranathan, V.; Monteiro, A.

10.1101/2021.10.19.464939 — developmental biology — Posted on 2022-02-11

2206 Determination of protein stoichiometries via dual-color colocalization with single molecule localization microscopy

Tan, H. L.; Bungert-Plümke, S.; Kortzak, D.; Fahlke, C.; Stölting, G.

10.1101/2021.10.05.463155 — cell biology — Posted on 2022-02-11

2207 Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

Nakayama, J.; Matsunaga, H.; Arikawa, K.; Yoda, T.; Hosokawa, M.; Takeyama, H.; Yamamoto, Y.; Semba, K.

10.1101/2021.10.21.465257 — cancer biology — Posted on 2022-02-11

2208 Preclinical establishment of a divalent vaccine against SARS-CoV-2

Wagner, L.; Hevesi, Z.; Harkany, T.; Gerges, D.; Schmetterer, K.; Pollak, D.; Frey, T.; Lang, R.; Freire, R.; Kapps, S.; Schmidt, S.; Schmidt, A.; Winnicki, W.

10.1101/2022.02.10.479919 — bioengineering — Posted on 2022-02-10

2209 Internet of Things Architecture for Cellular Biology

Parks, D. F.; Voitiuk, K.; Geng, J.; Elliott, M. A. T.; Keefe, M. G.; Jung, E. A.; Robbins, A.; Baudin, P. V.; Ly, V. T.; Hawthorne, N.; Yong, D.; Sanso, S. E.; Rezaee, N.; Sevetson, J. L.; Seiler, S. T.; Currie, R.; Pollen, A. A.; Hengen, K. B.; Nowakowski, T. J.; Salama, S. R.; Teodorescu, M.; Haussler, D.

10.1101/2021.07.29.453595 — bioengineering — Posted on 2022-02-10

2210 Cell delivery peptides for small interfering RNAs targeting SARS-CoV-2 new variants through a bioinformatics and deep learning design

Gonzalez, R. D.; Figueiredo, P. R.; Carvalho, A. T. P.

10.1101/2022.02.09.479755 — bioinformatics — Posted on 2022-02-10

2211 The rise and fall of SARS-CoV-2 variants and the emergence of competing Omicron lineages

Wiegand, T. R.; McVey, A.; Nemudraia, A.; Nemudryi, A.; Wiedenheft, B.

10.1101/2022.02.09.479842 — evolutionary biology — Posted on 2022-02-10

2212 SARS-CoV-2 Nsp1 N-terminal and linker regions as a platform for host translational shutoff

Graziadei, A.; Schildhauer, F.; Spahn, C.; Kraushar, M. L.; Rappsilber, J.

10.1101/2022.02.10.479924 — molecular biology — Posted on 2022-02-10

2213 Sexual transmission of Anopheles gambiae densovirus (AgDNV) leads to disseminated infection in mated females

Werling, K. L.; Johnson, R. M.; Metz, H. C.; Rasgon, J. L.

10.1101/2022.02.10.479983 — microbiology — Posted on 2022-02-10

2214 Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

Pitts, J.; Li, J.; Perry, J.; Du Pont, V.; Riola, N.; Rodriguez, L.; Lu, X.; Kurhade, C.; Xie, X.; Camus, G.; Manhas, S.; Martin, R.; Shi, P.-Y.; Cihlar, T.; Porter, D. P.; Mo, H.; Maiorova, E. S.; Bilello, J. P.

10.1101/2022.02.09.479840 — microbiology — Posted on 2022-02-10

2215 Dual Inhibition of Cathepsin L and 3CL-Pro by GC-376 Constrains SARS Cov2 Infection Including Omicron Variant

Prabhakar, B. S.; Kumar, P.; Ratia, K.; Richner, J. M.; Thatcher, G. R. J.; Kadam, R.; Smieszek, S. P.; Przychodzen, B. P.; Koprivica, V.; Birznieks, G.; Polymeropoulos, M. H.

10.1101/2022.02.09.479835 — microbiology — Posted on 2022-02-10

2216 Epigenetic Memory of COVID-19 in Innate Immune Cells and Their Progenitors

Cheong, J. G.; Ravishankar, A.; Sharma, S.; Parkhurst, C.; Nehar-Belaid, D.; Ma, S.; Paddock, L.; Fatou, B.; Karakaslar, E.; Thibodeau, A.; Bale, M.; Kartha, V.; Yee, J.; Mays, M. Y.; Leyre, L.; Martinez de Paz, A.; Daman, A.; Alvarez-Mulett, S.; Robbins, L.; LaFond, E.; Weidman, K.; Racine-Brzostek, S.; Yang, H.; Price, D.; Jones, R. B.; Schenck, E.; Kaner, R.; Chadburn, A.; Zhao, Z.; Steen, H.; Pascual, V.; Buenrostro, J.; Niec, R.; Lief, L.; Ucar, D.; Josefowicz, S.

10.1101/2022.02.09.479588 — immunology — Posted on 2022-02-10

2217 Lyophilized mRNA-lipid nanoparticles vaccine with long-term stability and high antigenicity against SARS-CoV-2

10.1101/2022.02.10.479867 — immunology — Posted on 2022-02-10

2218 InfoMuNet: Information-theory-based Functional Muscle Network Tracks Sensorimotor Integration Post-stroke

O'Keeffe, R.; Shirazi, S. Y.; Bilaloglu, S.; Jahed, S.; Bighamian, R.; Raghavan, P.; Atashzar, S. F.

10.1101/2022.02.10.479324 — neuroscience — Posted on 2022-02-10

2219 Digital twin reveals combinatorial code of non-linear computations in the mouse primary visual cortex

Ustyuzhaninov, I.; Burg, M. F.; Cadena, S. A.; Fu, J.; Muhammad, T.; Ponder, K.; Froudarakis, E.; Ding, Z.; Bethge, M.; Tolias, A.; Ecker, A. S.

10.1101/2022.02.10.479884 — neuroscience — Posted on 2022-02-10

2220 Inferring cell motility in complex environments with incomplete tracking data

Bundgaard, N.; Harmel, C.; Imle, A.; Sid Ahmed, S.; Frey, B.; Starruss, J.; Fackler, O. T.; Graw, F.

10.1101/2022.02.10.479738 — systems biology — Posted on 2022-02-10

2221 Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity

Aida, H.; Hashizume, T.; Ying, B.-W.

10.1101/2022.02.10.479953 — systems biology — Posted on 2022-02-10

2222 G protein-coupled estrogen receptor activation by Bisphenol-A disrupts protection from apoptosis conferred by estrogen receptors ERα and ERβ in pancreatic beta cells

Babiloni-Chust, I.; Dos Santos, R. S.; Medina-Gali, R. M.; Perez-Serna, A. A.; Encinar, J. A.; Martinez-Pinna, J.; Gustafsson, J.-A.; Marroqui, L.; Nadal, A.

10.1101/2022.01.31.478472 — physiology — Posted on 2022-02-10

2223 Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

Dickerson, M. T.; Dadi, P. K.; Zaborska, K. E.; Nakhe, A. Y.; Schaub, C. M.; Dobson, J. R.; Wright, N. M.; Lynch, J. C.; Scott, C. F.; Jacobson, D. A.

10.1101/2022.02.10.479802 — physiology — Posted on 2022-02-10

2224 Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

Rietdijk, J.; Aggarwal, T.; Georgieva, P.; Lapins, M.; Carreras-Puigvert, J.; Spjuth, O.

10.1101/2022.02.10.479889 — pharmacology and toxicology — Posted on 2022-02-10

2225 Heparins enhance C1 esterase inhibitor activity: a promising remedy for acute hereditary angioedema

Zhou, Y.; Maljuf-Cruz, A.; Dennis, J.; Woroch, E.; Hor, L.; Hellbusch, B.; Archuleta, E.; Fornis, L.; Garcia, C.; Aerts, S.; Bai, X.; Bevers, S.; Schmidt, E. P.; Bates, M.; Fugit, R.; Nieto-Martinez, S.; Galvan, M.; Giclas, P.; Frazer-Abel, A.; Chan, E.

10.1101/2022.02.10.479965 — pharmacology and toxicology — Posted on 2022-02-10

2226 Spatially Resolved and Highly Complexed Protein and RNA in situ Detection by Combining CODEX with RNAscope In Situ Hybridization

Cheng, Y.; Burrack, R. K.; Li, Q.

10.1101/2022.02.10.479971 — pathology — Posted on 2022-02-10

2227 Predicting Epitope Candidates for SARS-CoV-2

Agarwal, A.; Beck, K. L.; Capponi, S.; Kunitomi, M.; Nayar, G.; Seabolt, E.; Mahadeshwar, G.; Bianco, S.; Mukherjee, V.; Kaufman, J.

10.1101/2022.02.09.479786 — bioinformatics — Posted on 2022-02-10

2228 Engineering Defensin α-helix to produce high-affinity SARS-CoV-2 Spike protein binding ligands.

Fernandes, L. A.; Gomes, A. A.; Magalhaes, M. d. L. B.; Ray, P.; da Silva, G. F.

10.1101/2022.02.09.479781 — bioengineering — Posted on 2022-02-10

2229 Chemometrics-based evaluation on effect of sonication, contact time and solvent-to-solid ratio on total phenolics and flavonoids, fatty acids and antibacterial potency of Carica papaya seed against S. enteritidis, B. cereus, V. vulnificus and P. mirabilis

Abdullah Sani, M. S.

10.1101/2022.02.10.479904 — biochemistry — Posted on 2022-02-10

2230 Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry

Roberts, D. S.; Mann, M.; Li, B. H.; Kim, D.; Brasier, A. R.; Jin, S.; Ge, Y.

10.1101/2022.02.09.479776 — biochemistry — Posted on 2022-02-10

2231 Inactivation of Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse

Li, Y.; Xu, W.; Makova, S.; Brueckner, M.; Sun, Z.

10.1101/2022.02.10.479981 — genetics — Posted on 2022-02-10

2232 Goitered Gazelle's (Gazella Subgutturosa) Habitat Desirability Modeling by Using Maximum Entropy (Maxent) Method

Naqibzadeh, A.; Sarhangzadeh, J.; Sotoudeh, A.; Mashkour, M.; Thomalsky, J.

10.1101/2022.02.10.479956 — ecology — Posted on 2022-02-10

2233 Functional wetland loss drives emerging risks to waterbird migration networks

Donnelly, J. P.; Moore, J. N.; Casazza, M. L.; Coons, S. P.

10.1101/2022.01.24.477605 — ecology — Posted on 2022-02-10

2234 Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche

Anllo, L.; DiNardo, S.

10.1101/2021.09.08.459436 — developmental biology — Posted on 2022-02-10

2235 Mechanism of RNA Polymerase I selection by transcription factor UAF

Baudin, F.; Murciano, B.; Fung, H. K.; Fromm, S. A.; Mattei, S.; Mahamid, J.; Müller, C. W.

10.1101/2022.02.10.479882 — molecular biology — Posted on 2022-02-10

2236 Parallel Expansion and Divergence of the Hyr/Iff-like (Hil) Adhesin Family in Pathogenic Yeasts Including Candida auris

Smoak, R.; Snyder, L. F.; Fassler, J. S.; He, B. Z.

10.1101/2022.02.09.479577 — microbiology — Posted on 2022-02-10

2237 A deep learning pipeline for segmentation of Proteus mirabilis colony patterns

Doshi, A.; Shaw, M.; Tonea, R.; Minyety, R.; Moon, S.; Laine, A.; Guo, J.; Danino, T.

10.1101/2022.01.17.475672 — microbiology — Posted on 2022-02-10

2238 Single-cell RNA profiling of Plasmodium vivax liver stages reveals parasite- and host- specific transcriptomic signatures and drug targets

Ruberto, A. A.; Maher, S. P.; Vantaux, A.; Joyner, C. J.; Bourke, C.; Balan, B.; Jex, A.; Mueller, I.; Witkowski, B.; Kyle, D. E.

10.1101/2022.02.01.478648 — microbiology — Posted on 2022-02-10

2239 Evolution of inflammation and immunity in a dengue virus 1 human infection model

Waickman, A. T.; Lu, J. Q.; Fang, H.; Waldran, M.; Gebo, C.; Currier, J. R.; Van Wesenbeeck, L.; Verpoorten, N.; Lenz, O.; Tambuyzer, L.; Herrera-Taracena, G.; Van Loock, M.; Endy, T. P.; Thomas, S. J.

10.1101/2022.02.10.479935 — immunology — Posted on 2022-02-10

2240 HiDiver: A Suite of Methods to Merge Magnetic Resonance Histology, Light Sheet Microscopy, and Complete Brain Delineations

Johnson, G. A.; Tian, Y.; Cofer, G. P.; Cook, J. C.; Gee, J. C.; Hall, A.; Hornburg, K. J.; Qi, Y.; Yeh, F.-C.; Wang, N.; White, L. E.; Williams, R. W.

10.1101/2022.02.10.479607 — neuroscience — Posted on 2022-02-10

2241 Oligodendrocyte precursor cells engulf synaptic inputs in an experience- and microglia-dependent manner

Auguste, Y. S. S.; Ferro, A.; Dixon, J.; Vrudhula, U.; Kahng, J.; Nichitiu, A.-S.; Cheadle, L.

10.1101/2022.02.10.479887 — neuroscience — Posted on 2022-02-10

2242 Arginine-Vasopressin Expressing Neurons in the Murine Suprachiasmatic Nucleus Exhibit a Circadian Rhythm in Network Coherence in vivo

Stowie, A. C.; Qiao, Z.; Buonfiglio, D.; Ehlen, J. C.; Benveniste, M.; Davidson, A. J.

10.1101/2021.12.07.471437 — neuroscience — Posted on 2022-02-10

2243 Meningeal neutrophils play a role in modulating CNS output

Coulibaly, A. P.; Salken, I.; Provencio, J. J. P.

10.1101/2022.02.10.479966 — neuroscience — Posted on 2022-02-10

2244 Exploring the frame effect

Cavanagh, P.; Anstis, S.; Lisi, M.; Wexler, M.; Maechler, M.; 't Hart, B. M.; Shams-Ahmar, M.; Saleki, S.

10.1101/2022.02.10.479960 — neuroscience — Posted on 2022-02-10

2245 Glucose dynamics during ozone exposure measured using radiotelemetry: Stress drivers

Henriquez, A. R.; Snow, S. J.; Jackson, T. W.; House, J. S.; Motsinger-Reif, A. A.; Ward-Caviness, C.; Schladweiler, M. C.; Alewel, D. I.; Miller, C. N.; Farraj, A. K.; Hazari, M. S.; Grindstaff, R.; Diaz-Sanchez, D.; Ghio, A. J.; Kodavanti, U.

10.1101/2021.12.09.471963 — pharmacology and toxicology — Posted on 2022-02-10

2246 SOCIALITY, COMMUNITIES AND MORPHOLOGICAL FEATURES OF ANTS FROM MID-CRETACEOUS BURMESE AMBER

Perfilieva, K.

10.1101/2022.02.10.479968 — paleontology — Posted on 2022-02-10

2247 Comprehensive analysis of hsa-miR-654-5p's tumor-suppressing functions

Liu, C.; Min, L.; Kuang, J.; Zhu, C.-s.; Ma, J.; Qiu, X.-y.; Wu, X.; Zhang, T.; Xie, S.; Zhu, L.

10.1101/2020.12.20.423719 — cancer biology — Posted on 2022-02-10

2248 Comparison of proton transfer paths to the QA and QB sites of the Rb. sphaeroides photosynthetic reaction centers

Wei, R.; Zhang, Y.; Mao, J.; Matta, D.; Khaniya, U.; Gunner, M.

10.1101/2022.02.10.479886 — biophysics — Posted on 2022-02-10

2249 Histone H4K20 Trimethylation is Decreased in Murine Models of Heart Disease

Hickenlooper, S. M.; Davis, K.; Sheikh, H.; Miller, M.; Bia, R.; Valdez, S.; Szulik, M.; Franklin, S.

10.1101/2022.02.10.479885 — biochemistry — Posted on 2022-02-10

2250 Fentanyl reinstatement to discriminative cues after conflict in sign- and goal-tracking rats

Martin, D. A.; Keefer, S. E.; Calu, D. J.

10.1101/2022.02.10.479913 — animal behavior and cognition — Posted on 2022-02-10

2251 Integrated single-cell sequencing reveals principles of epigenetic regulation of human gastrulation and germ cell development in a 3D organoid model

Chialastri, A.; Karzbrun, E.; Khankhel, A. H.; Radeke, M. J.; Streichan, S. J.; Dey, S. S.

10.1101/2022.02.10.479957 — genomics — Posted on 2022-02-10

2252 High diversity of type I polyketide genes in Bacidia rubella as revealed by the comparative analysis of 23 lichen fungal genomes

Gerasimova, J. V.; Beck, A.; Werth, S.; Resl, P.

10.1101/2022.02.10.479404 — evolutionary biology — Posted on 2022-02-10

2253 Feedbacks between size and density determine rapid eco-phenotypic dynamics

Gibert, J. P.; Han, Z.-Y.; Wieczynski, D. J.; Votzke, S.; Yammine, A.

10.1101/2021.07.15.452551 — ecology — Posted on 2022-02-10

2254 Acoel single-cell atlas reveals expression dynamics and heterogeneity of a pluripotent stem cell population

Hulett, R. E.; Kimura, J. O.; Bolanos, D. M.; Luo, Y.-J.; Ricci, L.; Srivastava, M.

10.1101/2022.02.10.479464 — developmental biology — Posted on 2022-02-10

2255 Lem2 is essential for cardiac development by maintaining nuclear integrity

Ross, J.; Arcos-Villacis, N.; Battey, E.; Boogerd, C.; Marhuenda, E.; Hodzic, D.; Prin, F.; Mohun, T.; Catibog, N.; Tapia, O.; Gerace, L.; Iskratsch, T.; Shah, A.; Stroud, M.

10.1101/2022.02.10.477501 — cell biology — Posted on 2022-02-10

2256 Identification of CD317-Positive Pro-inflammatory Immune Stromal Cells in Human Mesenchymal Stromal Cell Preparations

Kay, A. G.; Fox, J. M.; Hewitson, J.; Stone, A.; Robertson, S.; James, S. R.; Wang, X.-N.; Kapasa, E.; Yang, X. B.; Genever, P. G.

10.1101/2022.02.10.479972 — cell biology — Posted on 2022-02-10

2257 Cortical neuronal differentiation is not impaired by elevated levels of α-synuclein in human pluripotent stem cells

Natalwala, A.; Behbehani, R.; Yapom, R.; Kunath, T.

10.1101/2022.02.10.479903 — cell biology — Posted on 2022-02-10

2258 The Ndc80 complex is essential for the initial kinetochore-microtubule capture during early mitosis

Amin, M. A.; Wallace, D. A.; Varma, D.

10.1101/2022.02.10.479964 — cell biology — Posted on 2022-02-10

2259 24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells

Zhu, C.; Boucheron, N.; Rica, R.; Stolz, V.; Halilbasic, E.; Claudel, T.; Al-Rubaye, O.; Lercher, A.; Baumgartner, M.; Sander, L.; Preglej, T.; Alteneder, M.; Mlitz, V.; Fuchs, C.; Hainberger, D.; Remetic, J.; Ohradanova-Repic, A.; Philipp, S.; Stojakovic, T.; Scharnagl, H.; Sakaguchi, S.; Bergthaler, A.; Stockinger, H.; Ellmeier, W.; Trauner, M.

10.1101/2022.02.10.479975 — molecular biology — Posted on 2022-02-10

2260 The RNA-binding protein landscapes differ between mammalian organs and cultured cells

Perez-Perri, J. I.; Ferring-Appel, D.; Huppertz, I.; Schwarzl, T.; Stein, F.; Rettel, M.; Galy, B.; Hentze, M. W.

10.1101/2022.02.10.479897 — molecular biology — Posted on 2022-02-10

2261 Simultaneous therapeutic targeting of inflammation and virus ameliorates influenza pneumonia and protects from morbidity and mortality

Pandey, P.; Al Rumaih, Z.; Kels, M. J. T.; Ng, E. M.; Kc, R.; Malley, R.; Chaudhri, G.; Karupiah, G.

10.1101/2022.02.09.479486 — microbiology — Posted on 2022-02-10

2262 A conserved biosynthetic gene cluster is regulated by quorum sensing in a shipworm symbiont

Robes, J. M. D.; Altamia, M. A.; Murdock, E. G.; Concepcion, G. P.; Haygood, M. G.; Puri, A. W.

10.1101/2022.02.10.479910 — microbiology — Posted on 2022-02-10

2263 The regulatory protein ChuP connects heme and siderophore-mediated iron acquisition systems required for Chromobacterium violaceum virulence

de Lima, V. M.; Batista, B. B.; da Silva Neto, J. F.

10.1101/2022.02.10.479982 — microbiology — Posted on 2022-02-10

2264 A B cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

Wang, J. C.; Yim, Y.-I.; Wu, X.; Jaumouille, V.; Cameron, A.; Waterman, C. M.; Kehrl, J. H.; Hammer, J. A.

10.1101/2021.08.12.456133 — immunology — Posted on 2022-02-10

2265 Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein (IL-18BP) in inflammation and tumor immunity

Detry, S.; Andries, J.; Bloch, Y.; Gabay, C.; Clancy, D.; Savvides, S. N.

10.1101/2022.02.10.479912 — immunology — Posted on 2022-02-10

2266 Assessing Quantitative MRI Techniques using Multimodal Comparisons

Carter, F.; Anwander, A.; Goucha, T.; Adamson, H.; Friederici, A. D.; Lutti, A.; Gauthier, C. J.; Weiskopf, N.; Bazin, P.-L.; Steele, C. J.

10.1101/2022.02.10.479780 — neuroscience — Posted on 2022-02-10

2267 Active tactile discrimination is coupled with and modulated by the cardiac cycle

Galvez-Pol, A.; Virdee, P.; Villacampa, J.; Kilner, J. M.

10.1101/2022.02.10.479959 — neuroscience — Posted on 2022-02-10

2268 Subcortical and cortical tracking of communication sound envelopes in challenging listening conditions

Souffi, S.; Varnet, L.; Zaidi, M.; Bathellier, B.; Huetz, C.; Edeline, J.-M.

10.1101/2022.02.10.479939 — neuroscience — Posted on 2022-02-10

2269 robustica: customizable robust independent component analysis

Anglada-Girotto, M.; Miravet-Verde, S.; Serrano, L.; Head, S. A.

10.1101/2021.12.10.471891 — systems biology — Posted on 2022-02-10

2270 The Voices of Medical Education Science: Describing the Published Landscape

Maggio, L.; Costello, J.; Ninkov, A.; Frank, J.; Artino, A. R.

10.1101/2022.02.10.479930 — scientific communication and education — Posted on 2022-02-10

2271 Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

Patil, N. P.; Gomez-Hernandez, A.; Zhang, F.; Cancel, L.; Feng, X.; Yan, L.; Xia, K.; Takematsu, E.; Yang, E.; Le, V.; Fisher, M.; Gonzalez-Rodriguez, A.; Garcia-Monzon, C.; Tunnell, J.; Tarbell, J.; Linhardt, R. J.; Baker, A. B.

10.1101/2022.02.10.479785 — physiology — Posted on 2022-02-10

2272 Protein binding and differential distribution of calcitonin in the sub-compartments of blood: An In vitro study

Bryan, A.; Kumar, A.

10.1101/2022.02.10.479976 — pharmacology and toxicology — Posted on 2022-02-10

2273 Longitudinally modeling anti-neoantigen immunity under paradigms of immunodominance

Qi, T.; Vincent, B.; Cao, Y.

10.1101/2022.02.10.479985 — cancer biology — Posted on 2022-02-10

2274 Recombination-aware Phylogeographic Inference Using the Structured Coalescent with Ancestral Recombination

Guo, F.; Carbone, I.; Rasmussen, D. A.

10.1101/2022.02.08.479599 — bioinformatics — Posted on 2022-02-10

2275 dbDEMC 3.0: Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms

Xu, F.; Wang, Y.; Lin, Y.; Zhou, C.; Wang, H.; Teschendorff, A. E.; Zhao, Y.; Zhao, H.; He, Y.; Zhang, G.; Yang, Z.

10.1101/2022.02.10.479911 — bioinformatics — Posted on 2022-02-10

2276 Metal-binding propensity in the mitochondrial dynamin-related protein 1

Roy, K.; Pucadyil, T.

10.1101/2022.01.15.476484 — biochemistry — Posted on 2022-02-10

2277 Architecture of the human erythrocyte ankyrin-1 complex

Vallese, F.; Kim, K.; Yen, L. Y.; Johnston, J. D.; Noble, A. J.; Cali, T.; Clarke, O. B.

10.1101/2022.02.10.479914 — biochemistry — Posted on 2022-02-10

2278 Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes

Yu, Y.; Chen, S.; Jones, S. J.; Hoque, R.; Vishnyakova, O.; Brooks-Wilson, A.; McNeney, B.

10.1101/2021.02.12.430986 — genetics — Posted on 2022-02-10

2279 Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay

Fielder, S. M.; Rosenfeld, J. A.; Burrage, L. C.; Emrick, L.; Lalani, S.; Attali, R.; Bembenek, J. N.; Hoang, H.; Baldridge, D.; Silverman, G. A.; Undiagnosed Diseases Network, ; Schedl, T.; Pak, S. C.

10.1101/2022.02.02.478908 — genetics — Posted on 2022-02-10

2280 Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba

Pettie, N.; Llopart, A.; Comeron, J.

10.1101/2022.02.10.479767 — genetics — Posted on 2022-02-10

2281 Plant phenotypic plasticity changes pollinator-mediated selection

Dorey, T.; Schiestl, F. P.

10.1101/2022.02.10.479857 — evolutionary biology — Posted on 2022-02-10

2282 Genomic signatures of hybridization on the neo-X chromosome of Rumex hastatulus

Beaudry, F. E. G.; Rifkin, J. L.; Peake, A. L.; Kim, D.; Jarvis-Cross, M.; Barrett, S. C.; Wright, S. I.

10.1101/2022.02.10.479988 — evolutionary biology — Posted on 2022-02-10

2283 Evolution of thermal physiology alters the projected range of threespine stickleback under climate change

Wuitchik, S. J.; Mogensen, S.; Barry, T. N.; Paccard, A.; Jamniczky, H. A.; Barrett, R. D.; Rogers, S. M.

10.1101/2021.02.25.432865 — ecology — Posted on 2022-02-10

2284 No leeway to enhance carbon sequestration and stock capacity via changes to forest management

Dalmonech, D.; Marano, G.; Amthor, J.; Cescatti, A.; Trotta, C.; Collalti, A.

10.1101/2022.02.10.479900 — ecology — Posted on 2022-02-10

2285 Trait-based population dynamics shape the contours of fitness landscapes

Siefert, A.; Laughlin, D. C.

10.1101/2022.02.10.479905 — ecology — Posted on 2022-02-10

2286 Reducing Cholesterol in Resting Macrophage Activates NF-kB through Mitochondria, Resulting in Epigenomic Reprogramming to Dampen Inflammation in Activated Macrophages

Zha, X.; Salloum, Z.; Dauner, K.; Nakka, K.; Verma, N.; Bandukwala, H.; Sorisky, A.; Dilworth, J.; Gonzalez, D. V.; Vedia, V. A.; Lopez-Montero, I.; McDonald, J.; Corley, C. D.

10.1101/2022.02.10.479926 — cell biology — Posted on 2022-02-10

2287 Mechanism of commitment to a mating partner in Saccharomyces cerevisiae

Jacobs, K. C.; Gorman, O.; Lew, D. J.

10.1101/2022.02.10.479952 — cell biology — Posted on 2022-02-10

2288 OzTracs: Optical Osmolality Reporters Engineered from Mechanosensitive Ion Channels

Kleist, T. J.; Lin, I. W.; Xu, S.; Maksaev, G.; Sadoine, M.; Haswell, E. S.; Frommer, W. B.; Wudick, M. M.

10.1101/2022.02.10.479916 — cell biology — Posted on 2022-02-10

2289 Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects

Brinkmann, V.; Romeo, M.; Larigot, L.; Hemmers, A.; Tschage, L.; Kleinjohann, J.; Schiavi, A.; Steinwachs, S.; Esser, C.; Menzel, R.; Tagliabue, S. G.; Bonati, L.; Cox, F.; Ale-Agha, N.; Jakobs, P.; Altschmied, J.; Haendeler, J.; Coumoul, X.; Ventura, N.

10.1101/2022.02.10.479676 — molecular biology — Posted on 2022-02-10

2290 IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR in hepatocytes, the stroma and cancer cells

Widjaja, A. A.; Goh, J. W. T.; Viswanathan, S.; Tan, J.; Shekeran, S. G.; Carling, D.; Lim, W.-W.; Cook, S. A.

10.1101/2022.02.10.479876 — molecular biology — Posted on 2022-02-10

2291 Sulfide toxicity as key control on anaerobic oxidation of methane in eutrophic coastal sediments

Dalcin Martins, P.; de Monlevad, J. P. R. C.; Lenstra, W. K.; Wallenius, A. J.; Echeveste Medrano, M. J.; Hermans, M.; Slomp, C. P.; Welte, C. U.; Jetten, M. S. M.; van Helmond, N. A. G. M.

10.1101/2022.02.10.479873 — microbiology — Posted on 2022-02-10

2292 Transcriptional response of individual Hawaiian Culex quinquefasciatus mosquitoes to the avian malaria parasite Plasmodium relictum

Ferreira, F. C.; Videvall, E.; Seidl, C. M.; Wagner, N. E.; Kilpatrick, A. M.; Fleischer, R. C.; Fonseca, D. M.

10.1101/2022.02.10.479890 — microbiology — Posted on 2022-02-10

2293 Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole animal dual RNA-seq

Jim, K. K.; Aprianto, R.; Domenech, A.; Kurushima, J.; van de Beek, D.; Vandenbroucke-Grauls, C. M. J. E.; Bitter, W.; Veening, J.-W.

10.1101/2022.02.10.479878 — microbiology — Posted on 2022-02-10

2294 CD8 T Cell Memory Inflation is Driven by Latent CMV Infection of Lymphatic Endothelial Cells

Hill, A. B.; Munks, M.; Rott, K.; Nesterenko, P.; Smart, S.; Smith, T.; Xu, G.; Williams, V.; Murray, S.; Tatum, A.

10.1101/2022.02.10.479848 — immunology — Posted on 2022-02-10

2295 Dietary palmitic acid induces innate immune memory via ceramide production that enhances severity of acute septic shock and clearance of infection

Seufert, A. L.; Hickman, J. W.; Traxler, S. K.; Peterson, R. M.; Lashley, S. J.; Shulzhenko, N.; Napier, R. J.; Napier, B. A.

10.1101/2021.06.15.448579 — immunology — Posted on 2022-02-10

2296 The midpoint of cortical thinning between late childhood and early adulthood differs across individuals and regions: Evidence from longitudinal modelling in a 12-wave sample

Fuhrmann, D.; Madsen, K. S.; Baruël Johansen, L.; Baare, W. F.; Kievit, R. A.

10.1101/2022.02.10.479868 — neuroscience — Posted on 2022-02-10

2297 Opponent processing in the retinal mosaic of nymphalid butterflies

Pirih, P.; Ilic, M.; Meglic, A.; Belusic, G.

10.1101/2022.02.10.479932 — neuroscience — Posted on 2022-02-10

2298 NICEgame: A workflow for annotating the knowledge gaps in metabolic reconstructions, using known and hypothetical reactions

Vayena, e.; Chiappino-Pepe, A.; MohammadiPeyhani, H.; Francioli, Y.; Hadadi, N.; Ataman, M.; Hafner, J.; Pavlou, S.; Hatzimanikatis, V.

10.1101/2022.02.10.479881 — systems biology — Posted on 2022-02-10

2299 Spliceosomic dysregulation unveils NOVA1 as an actionable therapeutic target in pancreatic neuroendocrine tumors

Pedraza-Arevalo, S.; Alors-Perez, E.; Blazquez-Encinas, R.; Herrera-Martinez, A. D.; Jimenez-Vacas, J. M.; Fuentes-Fayos, A. C.; Reyes, O.; Ventura, S.; Sanchez-Sanchez, R.; Ortega-Salas, R.; Serrano-Blanch, R.; Galvez-Moreno, M. A.; Gahete, M. D.; Ibanez-Costa, A.; Luque, R. M.; Castano, J. P.

10.1101/2022.02.09.479525 — cancer biology — Posted on 2022-02-10

2300 Controlling cluster size in 2D phase-separating binary mixtures with specific interactions

Palaia, I.; Saric, A.

10.1101/2022.02.10.479877 — biophysics — Posted on 2022-02-10

2301 Predictions of Skin Permeability Using Molecular Dynamics Simulation from Two-Dimensional Sampling of Spatial and Alchemical Perturbation Reaction Coordinates

Lundborg, M.; Wennberg, C.; Lidmar, J.; Hess, B.; Lindahl, E.; Norlen, L.

10.1101/2022.02.10.479880 — biophysics — Posted on 2022-02-10

2302 A pair of isoleucyl-tRNA synthetases in Bacilli fulfill complementary roles to enhance fitness and provide antibiotic resistance

Zanki, V.; Bozic, B.; Mocibob, M.; Ban, N.; Gruic-Sovulj, I.

10.1101/2022.02.09.479832 — biochemistry — Posted on 2022-02-10

2303 A pore-forming β-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3

Notova, S.; Bonnardel, F.; Rosato, F.; Siukstaite, L.; Schwaiger, J.; Bovin, N.; Varrot, A.; Roemer, W.; Lisacek, F.; Imberty, A.

10.1101/2022.02.10.479907 — biochemistry — Posted on 2022-02-10

2304 False-Positive IRESes from Hoxa9 and other genes resulting from errors in mammalian 5' UTR annotations

Akirtava, C.; May, G. E.; McManus, C. J.

10.1101/2022.02.10.479744 — genomics — Posted on 2022-02-10

2305 Sexual coercion in a natural mandrill population

Smit, N.; Baniel, A.; Roura-Torres, B.; Amblard-Rambert, P.; Charpentier, M. J. E.; Huchard, E.

10.1101/2022.02.07.479393 — ecology — Posted on 2022-02-10

2306 Compaction of Drosophila histoblasts in a crowded epidermis is driven by buckling of their apical junctions

Rigato, A.; Meng, H.; Abouakil, F.; LeGoff, L.

10.1101/2022.02.10.479869 — developmental biology — Posted on 2022-02-10

2307 Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

Phillips, J. E.; Santos, M.; Kanchwala, M.; Xing, C.; Pan, D.

10.1101/2021.11.15.468130 — cell biology — Posted on 2022-02-10

2308 Nutrient-dependent regulation of β-cell KATP channels is controlled by the isoforms of pyruvate kinase and the source of phosphoenolpyruvate

Foster, H. R.; Ho, T.; Potapenko, E.; Sdao, S. M.; Lewandowski, S. L.; VanDeusen, H. R.; Davidson, S. M.; Cardone, R. L.; Kibbey, R. G.; Merrins, M. J.

10.1101/2022.02.09.478817 — cell biology — Posted on 2022-02-10

2309 Staphylococcus aureus nt5 gene contributes to bacterial infection ability to form kidney abscess

Ye, Y.; Liu, X.; Xia, Z.; Tang, M.; Zhang, D.; He, F.; Zhang, P.; Liang, S.

10.1101/2022.02.09.479838 — immunology — Posted on 2022-02-10

2310 Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

Mijnheer, G.; Servaas, N. H.; Leong, J. Y.; Boltjes, A.; Spierings, E.; Chen, P.; Lai, L.; Petrelli, A.; Vastert, S.; De Boer, R. J.; Albani, S.; Pandit, A.; van Wijk, F.

10.1101/2022.02.10.479855 — immunology — Posted on 2022-02-10

2311 A single dose of the catecholamine precursor Tyrosine reduces physiological arousal and decreases decision thresholds in reinforcement learning and temporal discounting

Mathar, D.; Abdoust, M. E.; Tuszus, D.; Marrenbach, T.; Peters, J.

10.1101/2022.02.09.479693 — neuroscience — Posted on 2022-02-10

2312 An automated pipeline for extracting quantitative histological metrics for voxelwise MRI-histology comparisons

Kor, D. Z. L.; Jbabdi, S.; Huszar, I. N.; Mollink, J.; Tendler, B. C.; Foxley, S.; Wang, C.; Scott, C.; Smart, A.; Ansorge, O.; Pallebage-Gamarallage, M.; Miller, K. L.; Howard, A. F. D.

10.1101/2022.02.10.479718 — neuroscience — Posted on 2022-02-10

2313 Inducible Nitric Oxide Synthase deficiency leads to early demyelination by altering the balance between pro- and anti-inflammatory responses against Murine-β-Coronavirus

Kamble, M.; Saadi, F.; Kumar, S.; Saha, B.; Das Sarma, J.

10.1101/2022.02.08.479662 — neuroscience — Posted on 2022-02-10

2314 The dynamics of non-photochemical quenching and cyclic electron transport in A.thaliana exposed to harmonically oscillating light

Niu, Y.; Lazar, D.; Holzwarth, A. R.; Kramer, D. M.; Matsubara, S.; Schrey, S. D.; Nedbal, L.

10.1101/2022.02.09.479783 — plant biology — Posted on 2022-02-10

2315 A Novel congenic Mouse Model to study Obesity, Diabetes and NAFLD

Kumar, J. M.; Arindkar, S.; Nagarajan, P.

10.1101/2022.02.08.479645 — physiology — Posted on 2022-02-10

2316 Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis

Han, D. T.; Zhao, W.; Powell, W. H.

10.1101/2021.12.01.470809 — pharmacology and toxicology — Posted on 2022-02-10

2317 iDESC: Identifying differential expression in single-cell RNA sequencing data with multiple subjects

Liu, Y.; Wang, N.; Adams, T. S.; Schupp, J. C.; Wu, W.; McDonough, J. E.; Chupp, G. L.; Kaminski, N.; Wang, Z.; Yan, X.

10.1101/2022.02.07.479293 — bioinformatics — Posted on 2022-02-10

2318 Sound localization in world and head-centered space in ferrets

Town, S. M.; Bizley, J. K.

10.1101/2021.09.15.460425 — animal behavior and cognition — Posted on 2022-02-10

2319 Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse

Rinaldi, V.; Messemer, K.; Desevin, K.; Sun, F.; Berry, B.; Kukreja, S.; Tapper, A.; Wagers, A.; Rando, O.

10.1101/2022.02.08.479624 — genetics — Posted on 2022-02-10

2320 A simulation study of the ecological speciation conditions in the Galician marine snail Littorina saxatilis

Fernandez-Meirama, M.; Rolan-Alvarez, E.; Carvajal-Rodriguez, A.

10.1101/2022.02.08.479545 — evolutionary biology — Posted on 2022-02-10

2321 Protecting seabed sediment carbon for climate mitigation: a UK case study

Epstein, G.; Roberts, C. M.

10.1101/2022.02.10.479679 — ecology — Posted on 2022-02-10

2322 Bacterioplankton taxa compete for iron along the early spring-summer transition in the Arctic Ocean

Puente-Sanchez, F.; Macias, L.; Campbell, K. L.; Royo-Llonch, M.; Balague, V.; Sanchez, P.; Tamames, J.; Mundy, C. J.; Pedros-Alio, C.

10.1101/2022.02.07.479392 — ecology — Posted on 2022-02-10

2323 The Role of Notch Signaling in Endometrial Mesenchymal Stromal/Stem-like Cells Maintenance

Zhang, S.; Chan, R. W.; Ng, E. H.; Yeung, W. S.

10.1101/2022.02.09.479815 — cell biology — Posted on 2022-02-10

2324 Linear DNA amplicons as a novel cancer vaccine strategy

Conforti, A.; Salvatori, E.; Lione, L.; Compagnone, M.; Pinto, E.; Shorrock, C.; Hayward, J. A.; Sun, Y.; Liang, B. M.; Palombo, F.; Viscount, B.; Aurisicchio, L.

10.1101/2022.02.09.479777 — immunology — Posted on 2022-02-10

2325 Rose flavor compound β-damascone regulates dendritic cell-mediated immunoresponses by modulating the NRF2 pathway and ameliorates contact hypersensitivity

Kodama, N.; Okada, H.; Nagata, K.; Ando, M.; Ito, N.; Hiroki, I.; Yashiro, T.; Ichihara, G.; Yamamoto, M.; Hachisu, M.; Nishiyama, C.

10.1101/2022.02.08.479651 — immunology — Posted on 2022-02-10

2326 CD8 memory precursor cells generation is a continuous process

Todorov, H.; Prieux, M.; Laubreton, D.; Bouvier, M.; Wang, S.; De Bernard, S.; Arpin, C.; Cannoodt, R.; Saelens, W.; Bonnaffoux, A.; Gandrillon, O.; Crauste, F.; Saeys, Y.; Marvel, J.

10.1101/2022.02.09.479673 — immunology — Posted on 2022-02-10

2327 Inhibitory NPY neurons provide a large and heterotopic commissural projection in the inferior colliculus

Anair, J. D.; Silveira, M. A.; Mirjalili, P.; Beebe, N. L.; Schofield, B. R.; Roberts, M. T.

10.1101/2022.02.08.479582 — neuroscience — Posted on 2022-02-10

2328 A large-scale computational model to accurately predict early brain activity in response to written words

van Vliet, M.; Rinkinen, O.; Shimizu, T.; Devereux, B.; Salmelin, R.

10.1101/2022.02.08.479654 — neuroscience — Posted on 2022-02-10

2329 Crowdsourced EEG Experiments: A proof of concept for remote EEG acquisition using EmotivPRO Builder and EmotivLABS

Williams, N. S.; King, W.; Randeniya, R.; Mackellar, G.; McCormick, A.; Badcock, N. A.

10.1101/2022.02.09.479644 — neuroscience — Posted on 2022-02-10

2330 Recapitulation of Human Pathophysiology and Identification of Forensic Biomarkers in a Translational Swine Model of Chlorine Inhalation Injury

Achanta, S.; Gentile, M. A.; Albert, C. J.; Schulte, K. A.; Pantazides, B. G.; Crow, B. S.; Quinones-Gonzalez, J.; Perez, J. W.; Ford, D. A.; Patel, R. P.; Blake, T. A.; Gunn, M. D.; Jordt, S. E.

10.1101/2022.02.09.479576 — pharmacology and toxicology — Posted on 2022-02-10

2331 A new immunocompetent rectal cancer model to study radiation therapy

Kim, J. K.; Wu, C.; Del Latto, M.; Gao, Y.; Choi, S.-H.; Kierstead, M.; Sauve, C.-E. G.; Firat, C.; Perez, A. C.; Sillanpaa, J.; Chen, C.-T.; Lawrence, K. E.; Paty, P. B.; Barriga, F. M.; Shia, J.; Sawyers, C. L.; Lowe, S. W.; Garcia-Aguilar, J.; Romesser, P. B.; Smith, J. J.

10.1101/2022.02.07.479335 — cancer biology — Posted on 2022-02-10

2332 Single-cell molecular characterization to partition the human glioblastoma tumor microenvironment (TME) genetic background

Lessi, F.; Franceschi, S.; Morelli, M.; Menicagli, M.; Pasqualetti, F.; Santonocito, O.; Gambacciani, C.; Pieri, F.; Aquila, F.; Aretini, P.; Mazzanti, C. M.

10.1101/2022.02.10.479701 — cancer biology — Posted on 2022-02-10

2333 Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens

Abuhattum, S.; Kotzbeck, P.; Schluessler, R.; Harger, A.; Schellenberger, A. A.; Kim, K.; Escolano, J.-C.; Mueller, T.; Braun, J.; Wabitsch, M.; Tschoep, M.; Sack, I.; Brankatschk, M.; Guck, J.; Stemmer, K.; Taubenberger, A. V.

10.1101/2022.02.09.479760 — biophysics — Posted on 2022-02-10

2334 The guardian of the genome meets a viral master gene regulator at a biomolecular condensate

Borkosky, S. S.; Fassolari, M.; Campos-Leon, K.; Rossi, A. H.; Salgueiro, M.; Pascuale, C.; Peralta Martinez, R.; Gaston, K.; de Prat Gay, G.

10.1101/2022.02.09.479752 — biophysics — Posted on 2022-02-10

2335 An evaluation of RNA-seq differential analysis methods

Li, D.; Zand, M. S.; Dye, T. D.; Goniewicz, M. L.; Rahman, I.; Xie, Z.

10.1101/2022.02.09.479723 — bioinformatics — Posted on 2022-02-10

2336 Multinuclear MRI reveals early efficacy of stem cell therapy in stroke

Helsper, S.; Yuan, X.; Bagdasarian, F. A.; Athey, J.; Li, Y.; Borlongan, C. V.; Grant, S. C.

10.1101/2022.02.08.479630 — bioengineering — Posted on 2022-02-10

2337 A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish

Jimenez, E.; Slevin, C. C.; Song, W.; Chen, Z.; Frederickson, S. C.; Gildea, D.; Wu, W.; Elkahloun, A. G.; Ovcharenko, I.; Burgess, S. M.

10.1101/2022.02.09.479753 — genomics — Posted on 2022-02-10

2338 High sorbic acid resistance of Penicillium roqueforti is mediated by the SORBUS gene cluster

Punt, M.; Seekles, S. J.; Van Dam, J. L.; de Adelhart Toorop, C.; Martina, R. R.; Houbraken, J.; Ram, A. F. J.; Wösten, H. A. B.; Ohm, R. A.

10.1101/2022.02.10.479849 — genomics — Posted on 2022-02-10

2339 Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes

Sasaki, E.; Gunis, J.; Reichardt-Gomez, I.; Nizhynska, V.; Nordborg, M.

10.1101/2022.02.09.479810 — genetics — Posted on 2022-02-10

2340 The interplay between developmental stage and environment determines the adaptive effect of a natural transposable element insertion

Merenciano, M.; Gonzalez, J.

10.1101/2022.02.09.479730 — evolutionary biology — Posted on 2022-02-10

2341 Global determinants of the distribution of insect genetic diversity

French, C. M.; Bertola, L. D.; Carnaval, A. C.; Economo, E. P.; Kass, J. M.; Lohman, D. J.; Marske, K. A.; Meier, R.; Overcast, I.; Rominger, A. J.; Staniczenko, P.; Hickerson, M. J.

10.1101/2022.02.09.479762 — evolutionary biology — Posted on 2022-02-10

2342 Chimeric Inheritance and Crown-Group Acquisitions of Carbon Fixation Genes within Chlorobiales

Paoletti, M. M.; Fournier, G. P.

10.1101/2022.02.08.479544 — evolutionary biology — Posted on 2022-02-10

2343 Selective effects of a short transient environmental fluctuation on a natural population

Pfenninger, M.; Foucault, Q.; Waldvogel, A.-M.; Feldmeyer, B.

10.1101/2022.02.10.479864 — evolutionary biology — Posted on 2022-02-10

2344 Cast away on Mindoro island: could density dependence threaten tamaraw (Bubalus mindorensis) on the long term?

Bonenfant, C.; Rutschmann, A.; Burton, J.; Boyles, R.; Garcia, F.; Tliker, A.; Schütz, E.

10.1101/2020.05.07.051037 — ecology — Posted on 2022-02-10

2345 Actin remodelling controls proteasome homeostasis upon stress

Williams, T. D.; Cacioppo, R.; Agrotis, A.; Black, A.; Zhou, H.; Rousseau, A.

10.1101/2022.02.09.479706 — cell biology — Posted on 2022-02-10

2346 Parallel Expansion and Divergence of the Hyr/Iff-like (Hil) Adhesin Family in Pathogenic Yeasts Including Candida auris

He, B. Z.; Fassler, J. S.; Snyder, L. F.; Smoak, R.

10.1101/2022.02.09.479577 — microbiology — Posted on 2022-02-10

2347 The Composition of Diesel Fuel Influences the Structure of Microbiological Assemblages in Contaminated Fuel Storage Tanks

Floyd, J. G.; Stamps, B. W.; Bojanowski, C. L.; Crookes-Goodson, W. J.; Stevenson, B. S.

10.1101/2022.02.09.479836 — microbiology — Posted on 2022-02-10

2348 CD36 homologs determine microbial resistance to the Lyme disease spirochete

O'Neal, A. J.; Singh, N.; Forrest, I. S.; Rolandelli, A.; Wang, X.; Shaw, D. K.; Young, B. D.; Narasimhan, S.; Dutta, S.; Snyder, G. A.; Marnin, L.; Butler, L. R.; Samaddar, S.; Mendes, M. T.; Paz, F. E. C.; Valencia, L. M.; Sundberg, E. J.; Fikrig, E.; Pal, U.; Weber, D. J.; Do, R.; Pedra, J. H. F.

10.1101/2022.02.09.479763 — immunology — Posted on 2022-02-10

2349 Brain aging differs with cognitive ability regardless of education

Walhovd, K. B.; Nyberg, L.; Lindenberger, U.; Magnussen, F.; Amlien, I. K.; Sorensen, O.; Wang, Y.; Mowinckel, A. M.; Kievit, R.; Ebmeier, K. P.; Bartres-Faz, D.; Kuhn, S.; Boraxbekk, C.-J.; Ghisletta, P.; Madsen, K. S.; Baare, W.; Zsoldos, E.; Penninx, B.; Fjell, A.

10.1101/2022.02.09.479697 — neuroscience — Posted on 2022-02-10

2350 Direct Modulation Index: a measure of phase amplitude coupling for neurophysiology data

Scherer, M.; Wang, T.; Guggenberger, R.; Milosevic, L.; Gharabaghi, A.

10.1101/2022.02.07.479380 — neuroscience — Posted on 2022-02-10

2351 Task-dependent and automatic tracking of hierarchical linguistic structure

ten Oever, S.; Carta, S.; Kaufeld, G.; Martin, A. E.

10.1101/2022.02.08.479571 — neuroscience — Posted on 2022-02-10

2352 Single-cell multi-region dissection of brain vasculature in Alzheimer's Disease

Sun, N.; Akay, L. A.; Murdock, M. H.; Park, Y.; Bubnys, A.; Galani, K.; Mathys, H.; Jiang, X.; Ng, A. P.; Bennett, D. A.; Tsai, L.-H.; Kellis, M.

10.1101/2022.02.09.479797 — neuroscience — Posted on 2022-02-10

2353 Express detection and discrimination of visual objects by primate superior colliculus neurons

Bogadhi, A. R.; Hafed, Z. M.

10.1101/2022.02.08.479583 — neuroscience — Posted on 2022-02-10

2354 Not all noise-reduction methods for fMRI preprocessing are created equal

Hoeppli, M.-E.; Garenfeld, M. A.; Mortensen, C. K.; Nahman-Averbuch, H.; King, C. D.; Coghill, R. C.

10.1101/2022.02.08.478718 — neuroscience — Posted on 2022-02-10

2355 Impacts of Spaceflight Experience on Human Brain Structure

McGregor, H. R.; Hupfeld, K. E.; Pasternak, O.; Beltran, N. E.; De Dios, Y. E.; Bloomberg, J. J.; Wood, S. J.; Mulavara, A. P.; Riascos, R. F.; Reuter-Lorenz, P. A.; Seidler, R.

10.1101/2022.02.09.479297 — neuroscience — Posted on 2022-02-10

2356 A library for fMRI real-time processing systems in python (RTPSpy) with comprehensive online noise reduction, fast and accurate anatomical image processing, and online processing simulation

Misaki, M.; Bodurka, J.; Paulus, M. P.

10.1101/2021.12.13.472468 — neuroscience — Posted on 2022-02-10

2357 Effects of substrate on shrimp growth, water quality and bacterial community in the biofloc system nursing Penaeus vannamei postlarvae at a salinity of 5{per thousand}

Huang, H.-H.; Li, C.-Y.; Lei, Y.-J.; Kuang, W.-Q.; Zhou, B.-L.; Zou, W.-S.; Yang, P.-H.

10.1101/2022.02.08.479639 — zoology — Posted on 2022-02-10

2358 Rapid evaporative ionisation mass spectrometry (REIMS): A potential and rapid tool for the identification of insecticide resistance in mosquito larvae.

Morgan, J.; Salcedo-Sora, J. E.; Wagner, I.; Beynon, R. J.; Triana- Chavez, O. T.; Strode, C.

10.1101/2022.02.10.479854 — systems biology — Posted on 2022-02-10

2359 Reference nodule transcriptomes for Melilotus officinalis and Medicago sativa cv. Algonquin

Huang, R.; Snedden, W. A.; diCenzo, G. C.

10.1101/2022.02.08.479627 — plant biology — Posted on 2022-02-10

2360 Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers

Kim, D.; Gadad, S.; Setlem, R.; Kim, K.; Malladi, S.; Hou, T.; Nandu, T.; Camacho, C. V.; Kraus, W. L.

10.1101/2022.02.09.479778 — cancer biology — Posted on 2022-02-10

2361 High-Field Asymmetric Waveform Ion Mobility Spectrometry and Parallel Reaction Monitoring Increases Sensitivity for Clinical Biomarker Quantitation from Formalin-Fixed, Paraffin-Embedded Tumor Biopsies

Sweet, S. M.; Chain, D.; Yu, W.; Martin, P.; Rebelatto, M.; Chambers, A.; Cecchi, F.; Kim, Y. J.

10.1101/2022.02.08.479554 — cancer biology — Posted on 2022-02-10

2362 GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

Duan, S.; Sawyer, T. W.; Sontz, R. A.; Wieland, B. A.; Diaz, A. F.; Merchant, J. L.

10.1101/2022.02.10.479845 — cancer biology — Posted on 2022-02-10

2363 Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs

Aguirre, C.; Ikenaka, K.; So, M.; Maruno, T.; Yamaguchi, K.; Nakajima, K.; Choong, C.-J.; Nabekura, K.; Beck, G.; TOMII, K.; Yamamori, Y.; Doi, J.; Matsubara, T.; Morishima, M.; Kakuda, K.; Hideshim, M.; Kimura, Y.; Nagano, S.; Baba, K.; Murayama, S.; Ogi, H.; Nagai, Y.; Kawata, Y.; Uchiyama, S.; Miyanoiri, Y.; Goto, Y.; Mochizuki, H.

10.1101/2022.02.10.479831 — biophysics — Posted on 2022-02-10

2364 Mechanical feedback controls the emergence of dynamical memory in growing tissue monolayers

Sinha, S.; Li, X.; Das, R.; Thirumalai, D.

10.1101/2022.02.09.479806 — biophysics — Posted on 2022-02-10

2365 Identification of Catechins Binding Pockets in Monomeric Aβ42 Through Ensemble Docking and MD Simulations

Chavez Gracia, C.; Firouzi, R.; Sowlati-Hashjin, S.; Ashouri, M.; Karimi-Jafari, M. H.; Karttunen, M.

10.1101/2022.02.09.479729 — biophysics — Posted on 2022-02-10

2366 RCFGL: Rapid Condition adaptive Fused Graphical Lasso and application to modeling brain region co-expression networks

Seal, S.; Li, Q.; Basner, E. B.; Saba, L. M.; Kechris, K.

10.1101/2022.02.08.479613 — bioinformatics — Posted on 2022-02-10

2367 Differential CO2-fixation potentials and supporting roles of phagotrophy and proton pump among plankton lineages in a subtropical marginal sea

Li, H.; Lin, S.

10.1101/2022.02.09.479824 — bioinformatics — Posted on 2022-02-10

2368 Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome

Madrigal, P.; Singh, N. K.; Wood, J. M.; Gaudioso, E.; Hernandez-del-Olmo, F.; Mason, C. E.; Venkateswaran, K.; Beheshti, A.

10.1101/2022.02.07.479455 — bioinformatics — Posted on 2022-02-10

2369 A Systematic Approach for Explaining Time and Frequency Features Extracted by CNNs from Raw EEG Data

Ellis, C. A.; Miller, R. L.; Calhoun, V. D.

10.1101/2022.02.08.479555 — bioinformatics — Posted on 2022-02-10

2370 A Sulfonated Thermoresponsive Injectable Gel for Sequential Release of Therapeutic Proteins to Protect Cardiac Function After a Myocardial Infarction

ROCKER, A.; Cavasin, M.; Johnson, N. R.; Shandas, R.; Park, D.

10.1101/2022.02.07.479463 — bioengineering — Posted on 2022-02-10

2371 In-shoe plantar pressure depends on walking speed and type of weight-bearing activity in people with diabetes at high risk of ulceration

Hulshof, C. M.; van Netten, J. J.; Dekker, M. G.; Pijnappels, M.; Bus, S. A.

10.1101/2022.02.09.479511 — bioengineering — Posted on 2022-02-10

2372 Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate

Kriachkov, V.; McWilliam, H.; Mintern, J.; Amarasinghe, S. L.; Ritchie, M. E.; Furic, L.; Hatters, D. M.

10.1101/2022.02.09.479805 — biochemistry — Posted on 2022-02-10

2373 Ontogeny of learning and visual discrimination in zebrafish

Santaca', M.; Dadda, M.; Dalla Valle, L.; Fontana, C.; Gjinaj, G.; Bisazza, A.

10.1101/2022.02.09.479666 — animal behavior and cognition — Posted on 2022-02-10

2374 Investigating carbohydrate-rich feed supplements and the feeding preferences of European starlings (Sturnus vulgaris)

Brown, D. J.

10.1101/2022.02.08.479625 — animal behavior and cognition — Posted on 2022-02-10

2375 A historically balanced locus under recent directional selection in responding to changed nitrogen conditions during modern maize breeding

Xu, G.; Lyu, J.; Obata, T.; Liu, S.; Ge, Y.; Schnable, J. C.; Yang, J.

10.1101/2022.02.09.479784 — genomics — Posted on 2022-02-10

2376 Sen1 is a master regulator of transcription-driven conflicts

Aiello, U.; Challal, D.; Wentzinger, G.; Lengronne, A.; Appanah, R.; Pasero, P.; PALANCADE, B.; Libri, D.

10.1101/2022.02.09.479708 — genomics — Posted on 2022-02-10

2377 rG4-seq 2.0: enhanced transcriptome-wide RNA G-quadruplex structure sequencing for low RNA input samples

Zhao, J.; Chow, E. Y.-C.; Yeung, P. Y.; Zhang, Q. C.; Chan, T.-F.; Kwok, C. K.

10.1101/2022.02.10.479665 — genomics — Posted on 2022-02-10

2378 The genome of tropically adapted Brahman cattle (Bos taurus indicus) reveals novel genome variation in production animals

Ross, E. M.; Nguyen, L. T.; Lamb, H.; Moore, S.; Hayes, B.

10.1101/2022.02.09.479458 — genomics — Posted on 2022-02-10

2379 DBFE: Distribution-based feature extraction from copy number and structural variants in whole-genome data

Piernik, M.; Brzezinski, D.; Sztromwasser, P.; Pacewicz, K.; Majer-Burman, W.; Gniot, M.; Sielski, D.; Wozna, A.; Zawadzki, P.

10.1101/2022.02.09.479712 — genomics — Posted on 2022-02-10

2380 Whole-genome sequencing of Bantu-speakers from Angola and Mozambique reveals complex dispersal patterns and interactions throughout sub-Saharan Africa

Tallman, S. P.; Beleza, S.; das Dores Sungo, M.; Saranga, S.

10.1101/2022.02.07.478793 — genomics — Posted on 2022-02-10

2381 Single-cell analysis reveals a pathogenic cellular module associated with early allograft dysfunction after liver transplantation

Wang, Z.; Shao, X.; Wang, K.; Lu, X.; Zhuang, L.; Yang, X.; Zhang, P.; Yang, P.; Zheng, S.; Xu, X.; Fan, X.

10.1101/2022.02.09.479667 — genomics — Posted on 2022-02-10

2382 Modelling the spread of resistance to Varroa in Australian feral honeybee populations

Owen, R.; Scheerlinck, J.-P.; Stevenson, M.

10.1101/2022.02.10.479847 — evolutionary biology — Posted on 2022-02-10

2383 Controversy over the decline of arthropods: a matter of temporal baseline?

Duchenne, F.; Porcher, E.; Mihoub, J.-B.; Loïs, G.; Fontaine, C.

10.1101/2022.02.09.479422 — ecology — Posted on 2022-02-10

2384 Eukaryotic plankton community assembly and influencing factors between continental shelf and slope sites in the northern South China Sea

Lin, S.; Li, T.

10.1101/2022.02.09.479823 — ecology — Posted on 2022-02-10

2385 Ceramide-Rich Microdomains Facilitate Nuclear Envelope Budding during the Biogenesis of LTB4-containing Exosomes

Arya, S. B.; Chen, S.; Javed, F.; Parent, C.

10.1101/2022.02.09.479761 — cell biology — Posted on 2022-02-10

2386 The GTPase Activity of the Double FYVE Domain Containing Protein 1 (DFCP1) Regulates Lipid Droplet Metabolism.

Ismail, V. A.; Naismith, T.; Kast, D. J. E.

10.1101/2022.02.09.479746 — cell biology — Posted on 2022-02-10

2387 Functional LINC complex maintains epigenetic landscape and decondenses DNA in mature muscles

Amiad Pavlov, D.; Unnikannan, C.; Lorber, D.; Stoops, E.; Volk, T.

10.1101/2022.02.09.479725 — cell biology — Posted on 2022-02-10

2388 Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

Pan, G.; Lai, L.; Zhu, Y.; Zhang, Z.; Fan, N.; Huang, K.; Li, H.; Gu, J.; Zhang, Q.; Ouyang, Z.; Zhang, T.; Tang, J.; Zhang, Y.; Suo, Y.; Lai, C.; Wang, J.; Wang, J.; Shan, Y.; Wang, M.; Chen, Q.; Zhou, T.

10.1101/2022.02.10.479858 — cell biology — Posted on 2022-02-10

2389 Examination of rickettsial host range for shuttle vectors based on dnaA and parA genes from the pRM plasmid of Rickettsia monacensis

Burkhardt, N. Y.; Price, L. D.; Wang, X.-R.; Heu, C. C.; Baldridge, G. D.; Munderloh, U. G.; Kurtti, T. J.

10.1101/2022.02.09.479837 — microbiology — Posted on 2022-02-10

2390 HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut Microbiota

Kim, C. Y.; Ma, J.; Lee, I.

10.1101/2022.02.09.479829 — microbiology — Posted on 2022-02-10

2391 Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence

Fernandes, K. E.; Fraser, J. A.; Carter, D. A.

10.1101/2022.02.09.479843 — microbiology — Posted on 2022-02-10

2392 MraZ is a transcriptional inhibitor of cell division in Bacillus subtilis

White, M. L.; Hough-Neidig, A.; Khan, S. J.; Eswara, P. J.

10.1101/2022.02.09.479790 — microbiology — Posted on 2022-02-10

2393 Identification and characterization of the HERV-K (HML-8) group of human endogenous retroviruses in the genome

Liu, M.; Jia, L.; Li, H.; Liu, Y.; Han, J.; Zhai, X.; Wang, X.; Li, T.; Li, J.; Zhang, B.; Yu, C.; Li, L.

10.1101/2022.02.10.479833 — microbiology — Posted on 2022-02-10

2394 Functional Specialization of Specific DC Subsets in the Synovial Fluid of JIA Patients

Boltjes, A.; Samat, A. A. K.; Plantinga, M.; Mokry, M.; Castelijns, B.; Swart, J.; Vastert, S.; Creyghton, M.; Nierkens, S.; van Loosdregt, J.; van Wijk, F.

10.1101/2022.02.09.479707 — immunology — Posted on 2022-02-10

2395 FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis

Leng, F.; Zhang, W.; Ramirez, R.; Leon, J.; Zhong, Y.; van der Veeken, J.; Rudensk, A.; Benoist, C.; Hur, S.

10.1101/2022.02.08.479534 — immunology — Posted on 2022-02-10

2396 Targeting fatty acid beta-oxidation impairs monocyte differentiation and prolongs heart allograft survival

Zhu, Y.; Dun, H.; Ye, L.; Terada, Y.; Shriver, L.; Patti, G. J.; Kreisel, D.; Gelman, A. E.; Wong, B. W.

10.1101/2022.02.09.479789 — immunology — Posted on 2022-02-10

2397 The Structure-Selective Endonucleases GEN1 and MUS81 are Functionally Complementary in Safeguarding the Genome of Proliferating B Lymphocytes

Fernandez, K. C.; Feeney, L.; Smolkin, R. M.; Matthews, A. J.; Yen, W.-F.; Chaudhuri, J.; Petrini, J.

10.1101/2022.02.09.479711 — immunology — Posted on 2022-02-10

2398 Functionally competent CD4+ T cells express high levels of T-bet in Plasmodium chabaudi infected young mice

Smith, M. R.; GBEDANDE, K.; Johnson, C. M.; Campbell, L. A.; Richard, L. B.; Onjiko, R. S.; Domingos, N.; Opata, M. M.

10.1101/2022.02.08.479658 — immunology — Posted on 2022-02-10

2399 Selective integration of diverse taste inputs within a single taste modality

Deere, J. U.; Uttley, H. A.; Martinez Santana, N.; Devineni, A. V.

10.1101/2022.02.09.479727 — neuroscience — Posted on 2022-02-10

2400 Unbiased stereologic estimates of dopaminergic and GABAergic neurons in the A10, A9, and A8 subpopulations in the young male Macaque

Kelly, E. A.; Contreras, J.; Duan, A.; Vassell, R.; Fudge, J. L.

10.1101/2022.02.08.479596 — neuroscience — Posted on 2022-02-10

2401 Distinct features of the cortical N1 response to balance perturbation are associated with balance and cognitive impairments in Parkinson's disease

Payne, A. M.; McKay, J. L.; Ting, L. H.

10.1101/2022.02.08.479608 — neuroscience — Posted on 2022-02-10

2402 Principled clustering of functional signals reveals gradients in processing both within the anterior hippocampus and across its long axis

Thorp, J. N.; Gasser, C.; Blessing, E. M.; Davachi, L.

10.1101/2022.02.08.479587 — neuroscience — Posted on 2022-02-10

2403 Behavioral decomposition reveals rich encoding structure employed across neocortex

Mimica, B.; Tombaz, T.; Battistin, C.; Guo Fuglstad, J.; Dunn, B. A.; Whitlock, J. R.

10.1101/2022.02.08.479515 — neuroscience — Posted on 2022-02-10

2404 State-dependent activity dynamics of hypothalamic stress effector neurons

Ichiyama, A.; Mestern, S.; Benigno, G. B.; Scott, K.; Allman, B. L.; Muller, L.; Inoue, W.

10.1101/2022.02.10.479856 — neuroscience — Posted on 2022-02-10

2405 Reduced Hippocampal-Cortical Connectivity During Memory Suppression Predicts the Ability to Forget Unwanted Memories

Yan, Y.; Hulbert, J. C.; Zhuang, K.; Liu, W.; Wei, D.; Qiu, J.; Anderson, M. C.; Yang, W.

10.1101/2022.02.08.479070 — neuroscience — Posted on 2022-02-10

2406 A robust core architecture of functional brain networks supports topological resilience and cognitive performance in aging

Stanford, W. C.; Mucha, P. J.; Dayan, E.

10.1101/2022.02.07.479418 — neuroscience — Posted on 2022-02-10

2407 The direction and timing of theta and alpha traveling waves modulate human memory processing

Mohan, U. R.; Zhang, H.; Jacobs, J.

10.1101/2022.02.07.479466 — neuroscience — Posted on 2022-02-10

2408 M2 Receptors are required for spatiotemporal sequence learning in mouse primary visual cortex

Sarkar, S.; Martinez Reyes, C.; Jensen, C. M.; Gavornik, J. P.

10.1101/2022.02.09.479792 — neuroscience — Posted on 2022-02-10

2409 Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in APPNL-G-F mice

Brady, E. S.; Griffiths, J.; Andrianova, L.; Saito, T.; Sado, T. C.; Randall, A. D.; Tamagnini, F.; Witton, J.; Craig, M.

10.1101/2022.02.08.479119 — neuroscience — Posted on 2022-02-10

2410 CELLoGeNe - an Energy Landscape Framework for Logical Networks Controlling Cell Decisions

Andersson, E.; Sjö, M.; Kaji, K.; Olariu, V.

10.1101/2022.02.09.479734 — systems biology — Posted on 2022-02-10

2411 Exotic alleles contribute to heat tolerance in wheat under field conditions

Molero, G.; Coombes, B.; Joynson, R.; Pinto, F.; Pinera-Chavez, F. J.; Rivera-Amado, C.; Hall, A.; Reynolds, M. P.

10.1101/2022.02.09.479695 — plant biology — Posted on 2022-02-10

2412 TEMPRANILLO homologs in apple regulate flowering time in the woodland strawberry Fragaria vesca

Dejahang, A.; Maghsoudi, N.; Mousavi, A.; Farsad-Akhtar, N.; Hernandez, L. M.; Pelaz, S.; Folta, K. M.; Mahna, N.

10.1101/2022.02.08.479567 — plant biology — Posted on 2022-02-10

2413 Training induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability

Ely, I. A.; Jones, E. J.; Inns, T. B.; Dooley, S.; Miller, S. B. J.; Stashuk, D. W.; Atherton, P. J.; Phillips, B. E.; Piasecki, M.

10.1101/2022.02.10.479871 — physiology — Posted on 2022-02-10

2414 Cellular limitation of enzymatic capacity explains glutamine addiction in cancers

Gustafsson, J.; Roshanzamir, F.; Hagnestal, A.; Robinson, J. L.; Nielsen, J.

10.1101/2022.02.08.479584 — cancer biology — Posted on 2022-02-10

2415 A deep learning model trained on only eight whole-slide images accurately segments tumors: wise data use versus big data

Perennec, T.; Bourgade, R.; Henno, S.; Christine, S.; Toquet, C.; Rioux-Leclercq, N.; Kammerer-Jacquet, S.-F.; Loussouarn, D.; Griebel, M.

10.1101/2022.02.07.478680 — bioinformatics — Posted on 2022-02-10

2416 Automated speech detection in eco-acoustic data enables privacy protection and human disturbance quantification

Cretois, B.; Sethi, S. S.; Rosten, C.

10.1101/2022.02.08.479660 — bioinformatics — Posted on 2022-02-10

2417 DNABERT-based explainable lncRNA identification in plant genome assemblies

Danilevicz, M. F.; Gill, M.; Tay Fernandez, C. G.; Petereit, J.; Upadhyaya, S. R.; Batley, J.; Bennamoun, M.; Edwards, D.; Bayer, P. E.

10.1101/2022.02.09.479647 — bioinformatics — Posted on 2022-02-10

2418 Fine-Tuning Transformers For Genomic Tasks

Martinek, V.; Cechak, D.; Gresova, K.; Alexiou, P.; Simecek, P.

10.1101/2022.02.07.479412 — bioinformatics — Posted on 2022-02-10

2419 sgcocaller and comapr: personalised haplotype assembly and comparative crossover map analysis using single gametes

Lyu, R.; Tsui, V.; Crismani, W.; Liu, R.; Shim, H.; McCarthy, D. J.

10.1101/2022.02.10.479822 — bioinformatics — Posted on 2022-02-10

2420 An explainable unsupervised framework for alignment-free protein classification using sequence embeddings

Yeung, W.; Zhou, Z.; Mathew, L. G.; Gravel, N.; Taujale, R.; Venkat, A.; Lanzilotta, W.; Li, S.; Kannan, N.

10.1101/2022.02.08.478871 — bioinformatics — Posted on 2022-02-10

2421 Sensitive Spatiotemporal Tracking of Spontaneous Metastasis in Deep Tissues via a Genetically-Encoded Magnetic Resonance Imaging Reporter

Nyström, N. N.; McCrae, S.; Martinez, F. F.; Kelly, J. J.; Scholl, T. J.; Ronald, J. A.

10.1101/2022.02.09.479610 — bioengineering — Posted on 2022-02-10

2422 Continuous two-phase in vitro co-culture model of the enthesis

Park, H.; Cooke, M. E.; Lacombe, J.-G.; Weber, M. H.; Martineau, P. A.; Nazhat, S. N.; Rosenzweig, D.

10.1101/2022.02.07.479445 — bioengineering — Posted on 2022-02-10

2423 Mitonuclear interactions produce extreme differences in response to redox stress

Camus, M. F.; Kotiadis, V.; Carter, H.; Rodriguez, E.; Lane, N.

10.1101/2022.02.10.479862 — biochemistry — Posted on 2022-02-10

2424 Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

Wenzel, D. M.; Mackay, D. R.; Skalicky, J. J.; Paine, E. L.; Miller, M. S.; Ullman, K. S.; Sundquist, W. I.

10.1101/2022.02.09.477148 — biochemistry — Posted on 2022-02-10

2425 Pathogen prevalence modulates medication behavior in ant Formica fusca

Rissanen, J.; Helanterä, H.; Freitak, D.

10.1101/2022.02.09.479685 — animal behavior and cognition — Posted on 2022-02-10

2426 Building an atlas of transposable elements reveals the extensive roles of young SINE in gene regulation, genetic diversity, and complex traits in pigs

Zhao, P.; Gu, L.; Gao, Y.; Pan, Z.; Liu, L.; Li, X.; Zhou, H.; Yu, D.; Han, X.; Qian, L.; Liu, G. E.; Fang, L.; Wang, Z.

10.1101/2022.02.07.479475 — genomics — Posted on 2022-02-10

2427 Chromosome-scale genome assembly of the diploid oat Avena longiglumis reveals the landscape of repetitive sequences, genes and chromosome evolution in grasses

Liu, Q.; Yuan, H.; Li, M.; Wang, Z.; Cui, D.; Ye, Y.; Sun, Z.; Tan, X.; Schwarzacher, T.; Heslop-Harrison, J. S.

10.1101/2022.02.09.479819 — genomics — Posted on 2022-02-10

2428 Genomic stock structure of the marine teleost tarakihi (Nemadactylus macropterus) provides evidence of fine-scale adaptation and a temperature-associated cline amid panmixia

Papa, Y.; Morrison, M. A.; Wellenreuther, M.; Ritchie, P. A.

10.1101/2022.02.10.479861 — genomics — Posted on 2022-02-10

2429 Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice

Wu, Y.; Ren, Q.; Zhong, Z.; Liu, G.; Bao, Y.; Liu, L. L.; Xiang, S.; Liu, S.; Tang, X.; Zhou, J.; Zheng, X.; Sretenovic, S.; Zhang, T.; Qi, Y.; Zhang, Y.

10.1101/2022.02.09.479813 — genetics — Posted on 2022-02-10

2430 Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3

Cova, G.; Glaser, J.; Schoepflin, R.; Ali, S.; Prada-Medina, C. A.; Franke, M.; Falcone, R.; Federer, M.; Ponzi, E.; Ficarella, R.; Novara, F.; Wittler, L.; Timmermann, B.; Gentile, M.; Zuffardi, O.; Spielmann, M.; Mundlos, S.

10.1101/2022.02.09.479724 — genetics — Posted on 2022-02-10

2431 Early tetrapod diversification under neutral theory

Dunne, E. M.; Thompson, S. E. D.; Butler, R. J.; Rosindell, J.; Close, R. C.

10.1101/2022.02.08.476633 — evolutionary biology — Posted on 2022-02-10

2432 Comparing dormancy in two distantly related tunicates reveals morphological, molecular, and ecological convergences and repeated co-option

Hiebert, L. S.; Scelzo, M.; Alie, A.; De Tomaso, A. W.; Brown, F. D.; Tiozzo, S.

10.1101/2022.02.09.477513 — developmental biology — Posted on 2022-02-10

2433 The Requirement of Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in Mouse Ovarian Development and Fertility

Woodman, M. F.; Ozcan, M. C. H.; Gura, M. A.; De La Cruz, P.; Gadson, A. K.; Grive, K. J.

10.1101/2022.02.08.479454 — developmental biology — Posted on 2022-02-10

2434 TORC1, BORC, and ARL-8 cycling drive vesiculation of cell corpse phagolysosomes

Fazeli, G.; Levin-Konigsberg, R.; Bassik, M. C.; Stigloher, C.; Wehman, A. M.

10.1101/2022.02.09.479694 — cell biology — Posted on 2022-02-10

2435 Ethylene Insensitive 3-Like 2 (EIL2) is a Brassicaceae-specific transcriptional regulator involved in fine-tuning ethylene-dependent hypocotyl elongation, lateral root formation and flowering time in Arabidopsis thaliana

Houben, M.; Vaughan-Hirsch, J.; Mou, W.; Van de Poel, B.

10.1101/2022.02.09.479754 — molecular biology — Posted on 2022-02-10

2436 Dissecting aggregation and seeding dynamics of α-Syn polymorphs using the phasor approach to FLIM

Tittelmeier, J.; Druffel-Augustin, S.; Alik, A.; Melki, R.; Nussbaum-Krammer, C.

10.1101/2022.02.09.479740 — molecular biology — Posted on 2022-02-10

2437 A conundrum of r-protein stability: unbalanced stoichiometry of r-proteins during stationary phase in Escherichia coli

Reier, K.; Lahtvee, P.-J.; Liiv, A.; Remme, J.

10.1101/2022.02.09.479841 — molecular biology — Posted on 2022-02-10

2438 Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment, and H3K9me2 deposition

Burns, V. E.; Kerppola, T. K.

10.1101/2022.02.08.479619 — immunology — Posted on 2022-02-10

2439 Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging: insights from rhesus macaques

Rhoades, N. S.; Davies, M.; Lewis, S. A.; Cinco, I. R.; Kohama, S. G.; Bermudez, L. E.; Winthorp, K. L.; Fuss, C.; Mattison, J. A.; Spindel, E. R.; Messaoudi, I.

10.1101/2022.02.08.479578 — immunology — Posted on 2022-02-10

2440 Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

Baer, J. M.; Zuo, C.; Kang, L.-I.; Alarcon de la Lastra, A.; Borcherding, N. C.; Knolhoff, B. L.; Bogner, S. J.; Zhu, Y.; Lewis, M. A.; Zhang, N.; Kim, K.-w.; Fields, R. C.; Mills, J. C.; Ding, L.; Randolph, G. J.; DeNardo, D. G.

10.1101/2022.02.09.479745 — immunology — Posted on 2022-02-10

2441 Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity

Shlesinger, D.; Hong, K.-L.; Shammas, G.; Page, N.; Sandu, I.; Agrafiotis, A.; Kreiner, V.; Fonta, N.; Vincenti, I.; Wagner, I.; Piccinno, M.; Mariotte, A.; Klimek, B.; Dizerens, R.; Manero-Carranza, M.; Kuhn, R.; Ehling, R.; Frei, L.; Khodaverdi, K.; Panetti, C.; Joller, N.; Oxenius, A.; Merkler, D.; Reddy, S. T.; Yermanos, A.

10.1101/2022.02.07.479381 — immunology — Posted on 2022-02-10

2442 A parvocellular-magnocellular functional gradient in human visual cortex

Paz-Alonso, P. M.; Ibarbia-Garate, M.

10.1101/2022.02.08.479509 — neuroscience — Posted on 2022-02-10

2443 Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins

Martin, E. A.; Michel, J. C.; Kissinger, J. S.; Echeverry, F. A.; Lin, Y.-P.; O'Brien, J.; Pereda, A. E.; Miller, A. C.

10.1101/2022.02.07.479472 — neuroscience — Posted on 2022-02-10

2444 Network States Classification based on Local Field Potential Recordings in the Awake Mouse Neocortex

Zerlaut, Y.; Zucca, S.; Fellin, T.; Panzeri, S.

10.1101/2022.02.08.479568 — neuroscience — Posted on 2022-02-10

2445 Interaural time difference sensitivity under binaural cochlear implant stimulation even at high pulse rates up to 900 pps

Buck, A. N.; Buchholz, S.; Schnupp, J. W.; Rosskothen-Kuhl, N.

10.1101/2022.02.09.479686 — neuroscience — Posted on 2022-02-10

2446 Motor cortical influence relies on task-specific activity covariation

Warriner, C. L.; Fageiry, S.; Saxena, S.; Costa, R. M.; Miri, A.

10.1101/2022.02.09.479479 — neuroscience — Posted on 2022-02-10

2447 Shoulder muscle recruitment during the delay period encodes a reach movement plan which is sensitive to task context

Rungta, S. P.; Murthy, A.

10.1101/2022.02.09.479690 — neuroscience — Posted on 2022-02-10

2448 Integrating region- and network-level contributions to episodic recollection using multilevel structural equation modeling

Kurkela, K. A.; Cooper, R.; Ryu, E.; Ritchey, M.

10.1101/2022.02.08.478511 — neuroscience — Posted on 2022-02-10

2449 Unique neural coding of crucial versus irrelevant plant odors in a hawkmoth

Bisch-Knaden, S.; Rafter, M. A.; Knaden, M.; Hansson, B. S.

10.1101/2022.02.08.479530 — neuroscience — Posted on 2022-02-10

2450 A Robust and Automated Spike Sorting Method based on the Density Peaks

Zhang, Y.; Liu, T.; Yang, Z.; Chen, W.; Zhang, S.

10.1101/2022.02.10.479846 — neuroscience — Posted on 2022-02-10

2451 Automatic post-processing and merging of multiple spike-sorting analyses with Lussac

Llobet, V.; Wyngaard, A.; Barbour, B.

10.1101/2022.02.08.479192 — neuroscience — Posted on 2022-02-10

2452 An Optrode Array for Spatiotemporally Precise Large-Scale Optogenetic Stimulation of Deep Cortical Layers in Non-human Primates

Clark, A. M.; Ingold, A.; Reiche, C. F.; Cundy, D.; Balsor, J. L.; Federer, F.; McAlinden, N.; Cheng, Y.; Rolston, J. D.; Rieth, L.; Dawson, M. D.; Mathieson, K.; Blair, S.; Angelucci, A.

10.1101/2022.02.09.479779 — neuroscience — Posted on 2022-02-10

2453 Transient oscillations of neural firing rate associated with routing of evidence in a perceptual decision

Odean, N. N.; Sanayei, M.; Shadlen, M. N.

10.1101/2022.02.07.478903 — neuroscience — Posted on 2022-02-10

2454 Reconciling GenBank names with standardized avian taxonomies to improve linkage between phylogeny and phenotype

Hosner, P. A.; Zhao, M.; Kimball, R. T.; Braun, E. L.; Burleigh, G.

10.1101/2022.02.07.479408 — zoology — Posted on 2022-02-10

2455 First genetic data for the Critically Endangered Cuban endemic Zapata Rail Cyanolimnas cerverai, and the taxonomic implications

Brown, A. F.; Shannon, T. J.; Collinson, J. M.; Kirwan, G. M.; Kirkconnell, A.; Stervander, M.

10.1101/2022.02.07.477705 — zoology — Posted on 2022-02-10

2456 SC-RNA-seq assisted synthesis of a Boolean network to model early haematopoiesis aging

HERAULT, L.; POPLINEAU, M.; DUPREZ, E.; REMY, E.

10.1101/2022.02.08.479548 — systems biology — Posted on 2022-02-10

2457 A systems biology approach to elucidate the post-translational regulome of coronary artery disease

Sharma, A.; Ghatge, M.; Deshpande, V.; Vangala, R. k.

10.1101/2022.02.09.479759 — synthetic biology — Posted on 2022-02-10

2458 Simple and efficient modification of Golden Gate design standards and parts using oligo stitching

De Saeger, J.; Vermeersch, M.; Gaillochet, C.; Jacobs, T. B.

10.1101/2022.02.10.479870 — synthetic biology — Posted on 2022-02-10

2459 Biosynthesis and apoplast accumulation of the apocarotenoid pigment azafrin in parasitizing roots of Escobedia grandiflora

Cardona-Medina, E.; Santos, M.; Nodari, R.; Hornero-Mendez, D.; Peris, A.; Wong, D. C.; Matus, J. T.; Rodriguez-Concepcion, M.

10.1101/2022.02.07.479377 — plant biology — Posted on 2022-02-10

2460 SAI: Fast and automated quantification of stomatal parameters on microscope images

Sai, N.; Bockman, J. P.; Chen, H.; Watson-Haigh, N.; Xu, B.; Feng, X.; Piechatzek, A.; Shen, C.; Gilliham, M.

10.1101/2022.02.07.479482 — plant biology — Posted on 2022-02-10

2461 Genome-wide analysis of bromodomain gene family in Arabidopsis and Rice

V., A. T.; Sanyal, R. P.; Misra, H. S.; Saini, A.

10.1101/2022.02.08.479518 — plant biology — Posted on 2022-02-10

2462 Removal Of Environmental Pollutants (Lead, Chromium And Cadmium) Using Root And Leaf Tissues Of Indian Mustard, Rice And Wheat Plants

Halder, S.; Anirban, A.

10.1101/2022.02.08.479640 — plant biology — Posted on 2022-02-10

2463 Eradicating Citrus Greening By Dual Action Targeting of Liberibacter asiaticus and Diaphorina citri.

Farrell, C.; Triplett, E.; Theise, N. D.; Lowell, C. A.; Arment, A. R.

10.1101/2022.02.07.479449 — plant biology — Posted on 2022-02-10

2464 PDR6-mediated camalexin efflux and disease resistance are regulated through direct phosphorylation by the kinases OXI1 and AGC2-2

Miao, G.; Han, J.; Liu, C.-x.; Liu, J.; Wang, C.-r.; Wang, S.-c.

10.1101/2022.02.08.479400 — plant biology — Posted on 2022-02-10

2465 Using cGMP analogues to modulate photoreceptor light sensitivity: Perspectives for the treatment of retinal degeneration.

Wucherpfennig, S.; Haq, W.; Popp, V.; Kesh, S.; Das, S.; Melle, C.; Rentsch, A.; Schwede, F.; Paquet-Durand, F.; Nache, V.

10.1101/2022.02.07.478618 — physiology — Posted on 2022-02-10

2466 Testicular Dysgenesis Syndrome-like morphology and gene expression, and activation of Hypoxia Inducible Factor 1 Alpha in juvenile lamb testes following developmental exposure to low-level environmental chemical mixture.

Elcombe, C. S.; Monteiro, A.; Elcombe, M. R.; Ghasemzadeh-Hasankolaei, M.; Evans, N. P.; Bellingham, M.

10.1101/2022.02.08.479595 — pharmacology and toxicology — Posted on 2022-02-10

2467 Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies

Mundo, A. I.; Muhammad, A.; Balza, K.; Muldoon, T. J.; Nelson, C. E.

10.1101/2022.02.07.479423 — cancer biology — Posted on 2022-02-10

2468 Tree of mutually exclusive oncogenes

Neyshabouri, M. M.; Lagergren, J.

10.1101/2022.02.07.479425 — cancer biology — Posted on 2022-02-10

2469 Quantitative live-cell imaging of secretion activity reveals dynamic immune responses

Yamagishi, M.; Miyata, K.; Kamatani, T.; Kabata, H.; Baba, R.; Tanaka, Y.; Suzuki, N.; Matsuzaka, M.; Motomura, Y.; Kiniwa, T.; Koga, S.; Goda, K.; Ohara, O.; Funatsu, T.; Fukunaga, K.; Moro, K.; Uemura, S.; Shirasaki, Y.

10.1101/2022.02.09.479547 — biophysics — Posted on 2022-02-10

2470 Elasticity generates indissoluble biomolecular condensates

Meng, L.; Lin, J.

10.1101/2022.02.09.479808 — biophysics — Posted on 2022-02-10

2471 Multiphase condensates from a kinetically arrested phase transition

Erkamp, N. A.; Sneideris, T.; Ausserwoger, H.; Qian, D.; Qamar, S.; Nixon-Abell, J.; St George-Hyslop, P.; Schmit, J. D.; Weitz, D. A.; Knowles, T. P. J.

10.1101/2022.02.09.479538 — biophysics — Posted on 2022-02-10

2472 Clinically driven knowledge distillation for sparsifying high-dimensional multi-omics survival models

Wissel, D.; Rowson, D.; Boeva, V.

10.1101/2022.02.07.479388 — bioinformatics — Posted on 2022-02-10

2473 An Analysis of Protein Language Model Embeddings for Fold Prediction

Villegas-Morcillo, A.; Gomez, A. M.; Sanchez, V.

10.1101/2022.02.07.479394 — bioinformatics — Posted on 2022-02-10

2474 Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: A bioinformatics analytic workflow

De Silva, K.; Demmer, R. T.; Jonsson, D.; Mousa, A.; Forbes, A.; Enticott, J.

10.1101/2022.02.07.479483 — bioinformatics — Posted on 2022-02-10

2475 Resolving single-cell copy number profiling for large datasets

WANG, R.; ZHANG, Y.; WANG, M.; FENG, X.; WANG, J.; LI, S.

10.1101/2022.02.09.479672 — bioinformatics — Posted on 2022-02-10

2476 Growing Phylogenetic Trees Using Hierarchical Clustering

Eberhard, O.

10.1101/2022.02.08.479565 — bioinformatics — Posted on 2022-02-10

2477 Omics-informed CNV calls reduce false positive rate and improve power for CNV-trait associations

Lepamets, M.; Auwerx, C.; Noukas, M.; Claringbould, A.; Porcu, E.; Kals, M.; Jürgenson, T.; Estonian Biobank Research Team, ; Morris, A.; Vosa, U.; Bochud, M.; Stringhini, S.; Wijmenga, C.; Franke, L.; Peterson, H.; Vilo, J.; Lepik, K.; Mägi, R.; Kutalik, Z.

10.1101/2022.02.07.479374 — bioinformatics — Posted on 2022-02-10

2478 SPRI: Spatial Pattern Recognition using Information based method for spatial gene expression data

Hu, J.-X.; Yuan, Y.; Shen, H.-B.

10.1101/2022.02.09.479510 — bioinformatics — Posted on 2022-02-10

2479 Haplotype-enhanced inference of somatic copy number profiles from single-cell transcriptomes

Gao, T.; Soldatov, R.; Sarkar, H.; Kurkiewicz, A.; Biederstedt, E.; Loh, P.-R.; Kharchenko, P.

10.1101/2022.02.07.479314 — bioinformatics — Posted on 2022-02-10

2480 Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data

de Souza, V. B. C.; Jordan, B. T.; Tseng, E.; Nelson, E. A.; Hirschi, K. K.; Sheynkman, G. M.; Robinson, M. D.

10.1101/2022.02.08.479579 — bioinformatics — Posted on 2022-02-10

2481 Recombination-aware Phylogeographic Inference Using the Structured Coalescent with Ancestral Recombination

Guo, F.; Carbone, I.; Rasmussen, D.

10.1101/2022.02.08.479599 — bioinformatics — Posted on 2022-02-10

2482 Correlative imaging of spatio-angular dynamics of molecular assemblies and cells with multimodal instant polarization microscope

Ivanov, I. E.; Yeh, L.-H.; Perez-Bermejo, J. A.; Byrum, J. R.; Kim, J. Y. S.; Leonetti, M.; Mehta, S. B.

10.1101/2022.02.07.479448 — bioengineering — Posted on 2022-02-10

2483 Superparamagnetic iron oxide enclosed hollow gold nanostructure with tunable surface plasmon resonances to promote near-infrared photothermal conversion

Yuan, M.; Feng, X.; Yan, T.-H.; Chen, J.; Ma, X.; Cunha, P.; Lan, S.; Li, Y.; Zhou, H.-C.; Wang, Y.

10.1101/2022.02.07.479434 — bioengineering — Posted on 2022-02-10

2484 A simple DLP-bioprinting strategy produces cell-laden crypt-villous structures for an advanced 3D gut model

Torras, N.; Zabalo, J.; Abril, E.; Carré, A.; García-Díaz, M.; Martínez, E.

10.1101/2022.02.09.479715 — bioengineering — Posted on 2022-02-10

2485 Locomotor strategies inside the blind walks: freely moving previsual rat pups in the open field test

Midzyanovskaya, I. S.; Strelkov, V. V.

10.1101/2022.02.07.479442 — animal behavior and cognition — Posted on 2022-02-10

2486 Genome-wide profiling of histone H3K4me3 and H3K27me3 modifications in individual blastocysts by CUT&Tag without a solid support (NON-TiE-UP CUT&Tag)

Susami, K.; Ikeda, S.; Hoshino, Y.; Honda, S.; Minami, N.

10.1101/2022.02.07.479478 — genomics — Posted on 2022-02-10

2487 Genome-wide analysis and evolutionary history of the Necrosis and Ethylene-inducing peptide 1-like protein (NLP) superfamily across the Dothideomycetes class of fungi

Dal'Sasso, T. C. S.; Rody, H. V. S.; Oliveira, L. O.

10.1101/2022.02.07.479250 — evolutionary biology — Posted on 2022-02-10

2488 Host origin is a determinant of parallel evolution between influenza virus gene segments.

Jones, J. E.; Lakdawala, S.

10.1101/2022.02.07.479427 — evolutionary biology — Posted on 2022-02-10

2489 Resistance bioassays and allele characterisation inform Spodoptera frugiperda (Lepidoptera: Noctuidae) management and introduction pathways in Asia and Australia

Tay, W. T.; Rane, R. V.; James, W.; Gordon, K. H. J.; Downes, S.; Kim, J.; Kuniata, L.; Walsh, T. K.

10.1101/2022.02.08.479273 — evolutionary biology — Posted on 2022-02-10

2490 Landscape functional connectivity for butterflies under different scenarios of land-use, land-cover, and climate change in Australia

Diengdoh, V. L.; Ondei, S.; Amin, R. J.; Hunt, M.; Brook, B. W.

10.1101/2022.02.07.479372 — ecology — Posted on 2022-02-10

2491 Abundance and expression of hgcAB genes and mercury availability jointly explain methylmercury formation in stratified brackish waters

Capo, E.; Feng, C.; Bravo, A. G.; Bertilsson, S.; Soerensen, A. L.; Pinhassi, J.; Buck, M.; Karlsson, C.; Hawkes, J.; Björn, E.

10.1101/2022.02.08.479533 — ecology — Posted on 2022-02-10

2492 Latitudinal gradient in species diversity provides high niche opportunities for a range-expanding phytophagous insect

Jones, D. G.; Kobelt, J.; Ross, J.; Powell, T. H.; Prior, K. M.

10.1101/2022.02.07.479421 — ecology — Posted on 2022-02-10

2493 Spatially Resolved Transcriptomics for Evaluation of Intracranial Vessels in a Rabbit Model: Proof of Concept

Zabriskie, M. S.; Cooke, D. L.; Wang, C.; Alexander, M. D.

10.1101/2022.02.09.479726 — cell biology — Posted on 2022-02-10

2494 Systematic Single Cell Pathway Analysis (SCPA) reveals novel pathways engaged during early T cell activation

Bibby, J. A.; Agarwal, D.; Freiwald, T.; Kunz, N.; Merle, N. S.; West, E. E.; Larochelle, A.; Chinian, F.; Mukherjee, S.; Afzali, B.; Kemper, C.; Zhang, N. R.

10.1101/2022.02.07.478807 — immunology — Posted on 2022-02-10

2495 Immunomodulatory actions of a kynurenine-derived endogenous electrophile.

Carreno, M.; Pires, M. F.; Woodcock, S. R.; Brzoska, T.; Ghosh, S.; Salvatore, S. R.; Dunn, M.; Connors, N.; Yuan, S.; Straub, A. C.; Wendell, S. G.; Kato, G. J.; Freeman, B. A.; Ofori-Acquah, S.; Sundd, P.; Schopfer, F. J.; Vitturi, D. A.

10.1101/2022.02.08.479451 — immunology — Posted on 2022-02-10

2496 Semantic overlap protects from interference by restoring encoding mechanisms

Moore, I. L.; Long, N. M.

10.1101/2022.02.07.479444 — neuroscience — Posted on 2022-02-10

2497 Directional Absolute Coherence: a phase-based measure of effective connectivity for neurophysiology data

Scherer, M.; Wang, T.; Guggenberger, R.; Milosevic, L.; Gharabaghi, A.

10.1101/2022.02.07.479359 — neuroscience — Posted on 2022-02-10

2498 Conservative Significance Testing of Tripartite Interactions in Multivariate Neural Data

Fomins, A.; Sych, Y.; Helmchen, F.

10.1101/2022.02.07.479415 — neuroscience — Posted on 2022-02-10

2499 The relationship between frequency content and representational dynamics in the decoding of neurophysiological data

Higgins, C. J.; van Es, M. W. J.; Quinn, A. J.; Vidaurre, D.; Woolrich, M. W.

10.1101/2022.02.07.479399 — neuroscience — Posted on 2022-02-10

2500 Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking zonal transdifferentiation

Dufour, D.; Dumontet, T.; Sahut-Barnola, I.; Onzon, M.; Pussard, E.; Wilmouth, J.; Olabe, J.; Lucas, C.; Levasseur, A.; Pointud, J.-C.; Roucher-Boulez, F.; Tauveron, I.; Bossis, G.; Breault, D.; Yeh, E. T.; Val, P.; Lefrancois-Martinez, A. M.; Martinez, A.

10.1101/2022.02.08.479354 — physiology — Posted on 2022-02-10

2501 Chromosomal rearrangements with stable repertoires of genes and transposable elements in an invasive forest-pathogenic fungus

Demene, A.; Laurent, B.; Cros-Arteil, S.; Boury, C.; Dutech, C.

10.1101/2021.03.09.434572 — genomics — Posted on 2022-02-10

2502 Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing

Merkler, M.; Ip, N. Y.; Sakata, S.

10.1101/2022.02.09.479758 — neuroscience — Posted on 2022-02-10

2503 Cerebellar and cortico-striatal-midbrain contributions to reward-cognition processes and apathy within the psychosis continuum

Begue, I.; Brakowski, J.; Seifritz, E.; Dagher, A.; Tobler, P. N.; Kirschner, M.; Kaiser, S.

10.1101/2022.02.09.479617 — neuroscience — Posted on 2022-02-10

2504 Ingestion of microplastic fibres, but not microplastic beads, impacts growth rates in the tropical house cricket Gryllodes sigillatus

Fudlosid, S.; Ritchie, M. W.; Muzzatti, M. J.; Allison, J. E.; Provencher, J.; MacMillan, H. A.

10.1101/2022.02.07.479438 — physiology — Posted on 2022-02-10

2505 An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene

Azman, M. S.; Dodel, M.; Capraro, F.; Faraway, R.; Dermit, M.; Fan, W.; Ule, J.; Mardakheh, F. K.

10.1101/2021.12.16.472890 — cancer biology — Posted on 2022-02-10

2506 Looming stimuli reliably drive innate, but not learned, defensive responses in rats.

Heinemans, M.; Moita, M. A.

10.1101/2022.02.07.479432 — animal behavior and cognition — Posted on 2022-02-10

2507 Parasites make hosts more profitable but less available to predators

Prosnier, L.; Loeuille, N.; Hulot, F. D.; Renault, D.; Piscart, C.; Bicocchi, B.; Deparis, M.; Lam, M.; Medoc, V.

10.1101/2022.02.08.479552 — ecology — Posted on 2022-02-10

2508 Binned Relative Environmental Change Indicator (BRECI): A tool to communicate the nature of differences between environmental niche model outputs

Wilson, P. D.

10.1101/672618 — ecology — Posted on 2022-02-10

2509 MUCOSECRETORY LUNG DISEASE: DIFFERENT ASSEMBLIES OF JAG1 AND JAG2 DETERMINE TRACHEOBRONCHIAL CELL FATE

Reynolds, S. D.; Hill, C. L.; Alsudayri, A.; Lallier, S. W.; Wijeratne, S.; Tan, Z. H.; Chiang, T.; Cormet-Boyaka, E.

10.1101/2022.01.29.478334 — cell biology — Posted on 2022-02-10

2510 Mate Competition Drives Aggressive Behaviour in Female Drosophila

Gaspar, M.; Dias, S.; Vasconcelos, M. L.

10.1101/2022.02.07.479369 — neuroscience — Posted on 2022-02-10

2511 Pictorial balance is a bottom-up aesthetic property mediated by eye movements. Balance is explained by a theoretical primitive visual operating system following moving animate objects

Corwin, D. M.

10.1101/2020.05.26.104687 — neuroscience — Posted on 2022-02-10

2512 Group-level inference of information-based measures for the analyses of cognitive brain networks from neurophysiological data

Combrisson, E.; Allegra, M.; Basanisi, R.; Ince, R. A. A.; Giordano, B. L.; Bastin, J.; Brovelli, A.

10.1101/2021.08.14.456339 — neuroscience — Posted on 2022-02-10

2513 Conflict detection in a sequential decision task is associated with increased cortico-subthalamic coherence and prolonged subthalamic oscillatory response in the beta band.

Patai, E. Z.; Foltynie, T.; Limousin, P.; Zrinzo, L.; Bogacz, R.; Litvak, V.

10.1101/2020.06.09.141713 — neuroscience — Posted on 2022-02-10

2514 Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Baba?i?, H.; Galardi, S.; Umer, H.; Cardinali, D.; Pellegata, S.; Hellström, M.; Uhrbom, L.; Maturi, N.; Michienzi, A.; Trevisi, G.; Mangiola, A.; Lehtiö, J.; Ciafre, S. A.; Pernemalm, M.

10.1101/2022.02.06.479313 — cancer biology — Posted on 2022-02-10

2515 Fused in Sarcoma undergoes cold denaturation: implications on phase separation

Felix, S.; Laurents, D. V.; Oroz, J.; Cabrita, E. J.

10.1101/2022.02.08.479505 — biophysics — Posted on 2022-02-10

2516 Scalability of large neural network simulations via activity tracking with time asynchrony and procedural connectivity

Mascart, C.; Scarella, G.; Reynaud-Bouret, P.; Muzy, A.

10.1101/2021.06.12.448096 — neuroscience — Posted on 2022-02-10

2517 Attentional Modulations of Alpha Power Are Sensitive to the Task-relevance of Auditory Spatial Information

Klatt, L.-I.; Getzmann, S.; Schneider, D.

10.1101/2021.02.12.430942 — neuroscience — Posted on 2022-02-10

2518 Morphology of immatures of the thelytokous ant, Monomorium triviale Wheeler (Formicidae: Myrmicinae: Solenopsidini) with descriptions of the extraordinary last-instar queen larvae

Idogawa, N.; Gotoh, A.; Dobata, S.

10.1101/2021.11.07.467650 — zoology — Posted on 2022-02-10

2519 Transcriptional regulation and chromatin architecture maintenance are decoupled modular functions at the Sox2 locus

Taylor, T.; Sikorska, N.; Shchuka, V. M.; Chahar, S.; Ji, C.; Mcpherson, N. N.; Moorthy, S. D.; Mitchell, J. A.; Sexton, T.

10.1101/2022.02.09.479674 — genetics — Posted on 2022-02-10

2520 Statistical learning is not error-driven

Nazli, I.; Ferrari, A.; Huber-Huber, C.; de Lange, F. P.

10.1101/2022.02.07.479428 — neuroscience — Posted on 2022-02-10

2521 Converging pathways found in copy number variation syndromes with high schizophrenia risk

Ehrhart, F.; Silva, A.; Amelsvoort, T.; von Scheibler, E.; Evelo, C.; Linden, D. E. J.

10.1101/2022.02.07.479370 — systems biology — Posted on 2022-02-10

2522 Screening for functional regulatory variants in open chromatin using GenIE-ATAC

Cooper, S. E.; Schwartzentruber, J.; Coomber, E. L.; Wu, Q.; Bassett, A. R.

10.1101/2022.02.09.479775 — genetics — Posted on 2022-02-10

2523 DNA barcoding of fungal specimens using long-read high-throughput sequencing

Runnel, K.; Abarenkov, K.; Copot, O.; Mikryukov, V.; Koljalg, U.; Saar, I.; Tedersoo, L.

10.1101/2022.02.08.479507 — molecular biology — Posted on 2022-02-09

2524 Maternally inherited siRNAs initiate piRNA cluster formation

Luo, Y.; He, P.; Kanrar, N.; Toth, K. F.; Aravin, A.

10.1101/2022.02.08.479612 — molecular biology — Posted on 2022-02-09

2525 Multistep loading of PCNA onto DNA by RFC

Schrecker, M.; Castaneda, J. C.; Kumar, C.; Devbhandari, S.; Remus, D.; Hite, R. K.

10.1101/2022.02.09.479782 — molecular biology — Posted on 2022-02-09

2526 An intergeneric recombinant geminivirus causes soybean stay-green disease

Xu, Y.; Cheng, R.; Mei, R.; Yan, R.; Chen, H.; Miao, D.; Cai, L.; Fan, J.; Li, G.; Xu, R.; Lu, W.; Gao, Y.; Ye, W.; Su, S.; Han, T.; Gai, J.; Wang, Y.; Tao, X.

10.1101/2022.02.09.479675 — microbiology — Posted on 2022-02-09

2527 A network model of glymphatic flow under different experimentally-motivated parametric scenarios

Tithof, J.; Boster, K. A. S.; Bork, P. A. R.; Nedergaard, M.; Thomas, J. H.; Kelley, D. H.

10.1101/2021.09.23.461519 — neuroscience — Posted on 2022-02-09

2528 Low-level Action Schemas Support Gaze Guidance Behavior for Action Planning and Execution in Novel Tasks

Keshava, A.; Nezami, F. N.; Neumann, H.; Izdebski, K.; Schueler, T.; Koenig, P.

10.1101/2021.01.29.428782 — neuroscience — Posted on 2022-02-09

2529 Time-resolved parameterization of aperiodic and periodic brain activity

Wilson, L. E.; da Silva Castanheira, J.; Baillet, S.

10.1101/2022.01.21.477243 — neuroscience — Posted on 2022-02-09

2530 Matrix-driven jamming dynamics mediates transition of ovarian cancer spheroids to stable morphologies

Dutt, T.; Langthasa, J.; U, M.; Sen, P.; Bhat, R.

10.1101/2022.02.09.479678 — biophysics — Posted on 2022-02-09

2531 Membrane binding of pore-forming γ-hemolysin components studied at different lipid compositions

Tarenzi, T.; Lattanzi, G.; Potestio, R.

10.1101/2022.02.08.479512 — biophysics — Posted on 2022-02-09

2532 Freestanding Hydrogel Lumens for Biological Assays

Dostie, A. M.; Lea, H. G.; Lee, U. N.; van Neel, T. L.; Berthier, E.; Theberge, A. B.

10.1101/2021.10.19.464875 — bioengineering — Posted on 2022-02-09

2533 A catalytic mechanism for Renilla-type bioluminescence

Schenkmayerova, A.; Toul, M.; Pluskal, D.; Baatallah, R.; Gagnot, G.; Pinto, G. P.; Santana, V. T.; Stuchla, M.; Neugebauer, P.; Chaiyen, P.; Damborsky, J.; Bednar, D.; Janin, Y. L.; Prokop, Z.; Marek, M.

10.1101/2022.02.09.479090 — biochemistry — Posted on 2022-02-09

2534 A Multiscale study of phosphorylcholine driven cellular phenotypic targeting

Acosta-Gutierrez, S.; Matias, D.; Avila-Olias, M.; Gouveia, V. M.; Scarpa, E.; Forth, J.; Contini, C.; Duro-Castano, A.; Rizzello, L.; Battaglia, G.

10.1101/2022.02.09.479395 — biochemistry — Posted on 2022-02-09

2535 Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration

Fiedler, S.; Devenish, S. R. A.; Morgunov, A. S.; Ilsley, A.; Ricci, F.; Emmenegger, M.; Kosmoliaptsis, V.; Theel, E. S.; Mills, J. R.; Sholukh, A. M.; Aguzzi, A. A. A.; Iwasaki, A.; Lynn, A. K.; Knowles, T. P. J.

10.1101/2022.02.03.478946 — biochemistry — Posted on 2022-02-09

2536 Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal degeneration

Du, J.; Zhu, S.; Huang, J.; Xu, R.; Wang, Y.; Wan, Y.; McNeel, R.; Parker, E. D.; Kolson, D.; Yam, M.; Webb, B.; Zhao, C.

10.1101/2022.02.09.479735 — biochemistry — Posted on 2022-02-09

2537 Rtt109 promotes nucleosome replacement ahead of the replicating fork

Jonas, F.; Yaakov, G.; Barkai, N.

10.1101/2022.02.09.479766 — genomics — Posted on 2022-02-09

2538 Mutagenesis at non-B DNA motifs in the human genome: a course correction

McGinty, R. J.; Sunyaev, S. R.

10.1101/2022.02.08.479604 — genomics — Posted on 2022-02-09

2539 The Chromosome-level Genome of Dracaena cochinchinesis Provides Insights into its Biological Features and the Mechanism of Dragon's Blood Formation

Xu, Y.; Zhang, K.; Zhang, Z.; Liu, Y.; Lv, F.; Sun, P.; Gao, S.; Wang, Q.; Yu, C.; Jiang, J.; Li, C.; Song, M.; Gao, Z.; Sui, C.; Li, H.; Jin, Y.; Guo, X.; Wei, J.

10.1101/2022.02.08.479636 — genomics — Posted on 2022-02-09

2540 Genome-wide association reveals host-specific genomic traits in Escherichia coli

Tiwari, S. K.; van der Putten, B. C. L.; Fuchs, T. M.; Vinh, T. N.; Bootsma, M.; Oldenkamp, R.; La Ragione, R.; Matamoros, S.; Hoa, N. T.; Berens, C.; Leng, J.; Alvarez, J.; Ferrandis-Vila, M.; Ritchie, J. M.; Fruth, A.; Schwarz, S.; Dominguez, L.; Ugarte-Ruiz, M.; Bethe, A.; Huber, C.; Johanns, V.; Stamm, I.; Wieler, L. H.; Ewers, C.; Fivian-Hughes, A.; Schmidt, H.; Menge, C.; Semmler, T.; Schultsz, C.

10.1101/2022.02.08.479532 — genomics — Posted on 2022-02-09

2541 Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus

Harris, R. A.; Raveendran, M.; Lyfoung, D. T.; Sedlazeck, F. J.; Mahmoud, M.; Prall, T.; Karl, J.; Doddapaneni, H.; Meng, Q.; Han, Y.; Muzny, D.; Wiseman, R. W.; O'Connor, D. H.; Rogers, J.

10.1101/2021.07.05.451071 — genomics — Posted on 2022-02-09

2542 Strong genotype by environment interactions in the rice Global MAGIC population across seedling stage drought

Moyers, B. T.; Henry, A.; Raghavan, C.; Zaw, H.; Marrano, A.; Leung, H.; McKay, J. K.

10.1101/2022.02.07.479433 — genetics — Posted on 2022-02-09

2543 Enviromic prediction is useful to define the limits of climate adaptation: A case study of common beans in Brazil

Heinemann, A. B.; da Matta, D. H.; Fernandes, I. K.; Fritsche-Neto, R.; Costa-Neto, G. M. F.

10.1101/2022.02.07.478581 — genetics — Posted on 2022-02-09

2544 Seasonal dynamics of the wild rodent faecal virome

Raghwani, J.; Faust, C. L.; Francois, S.; Nguyen, D.; Marsh, K.; Raulo, A.; Hill, S. C.; Parag, K. V.; Simmonds, P.; Knowles, S. C. L.; Pybus, O. G.

10.1101/2022.02.09.479684 — ecology — Posted on 2022-02-09

2545 Anti-inflammatory effects of WFS1 in pancreatic beta-cells

Morikawa, S.; Blacher, L.; Onwumere, C.; Urano, F.

10.1101/2022.02.09.479773 — molecular biology — Posted on 2022-02-09

2546 Modulation of RNA polymerase processivity affects double-strand break repair in the presence of a DNA-end binding protein

Sivaramakrishnan, P.; Bradley, C. C.; Artsimovitch, I.; Hagstrom, K. M.; Ramirez, L. D.; Wen, X.; Cooke, M.; Shaulsky, M.; Herman, C.; Halliday, J. A.

10.1101/2022.02.08.479637 — molecular biology — Posted on 2022-02-09

2547 Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies

Molitor, L.; Klostermann, M.; Bacher, S.; Spranger, N.; Merl-Pham, J.; Rusha, E.; Tews, D.; Pertek, A.; Proske, M.; Busch, A.; Reschke, S.; Burczyk, S.; Feederle, R.; Hauck, S. M.; Blum, H.; Drukker, M.; Fischer-Posovszky, P.; Koenig, J.; Zarnack, K.; Niessing, D.

10.1101/2022.02.09.479353 — molecular biology — Posted on 2022-02-09

2548 Validation of a colorimetric LAMP to detect Loxosceles experimental envenomation

Fernandes, L. P.; Rocha, M. N.; Guerra-Duarte, C.; Minozzo, J. C.; Monte-Neto, R.; Felicori, L.

10.1101/2022.02.09.479769 — molecular biology — Posted on 2022-02-09

2549 Disrupted development and altered hormone signaling in male Padi2/Padi4 double knockout mice

Sams, K. L.; Mukai, C.; Marks, B. A.; Mittal, C. L.; Demeter, E. A.; Nelissen, S.; Grenier, J. K.; Tate, A. E.; Ahmed, F.; Coonrod, S. A.

10.1101/2022.02.09.479603 — molecular biology — Posted on 2022-02-09

2550 Enhanced production of antiviral dsRNA in the Chlamydomonas reinhardtii chloroplast via a novel convergent promoter expression system

CHAROONNART, P.; Tuant, H.; Webb, C.; Purton, S.; Robinson, C.; Saksmerprome, V.

10.1101/2022.02.09.479659 — molecular biology — Posted on 2022-02-09

2551 N-acylethanolamine acid amide hydrolase is a novel target for drugs against SARS-CoV-2 and Zika virus

Lai, M.; La Rocca, V.; Amato, R.; Iacono, E.; filipponi, c.; Catelli, E.; Bogani, L.; Fonnesu, R.; lottini, g.; De Carli, A.; Mengozzi, A.; Masi, S.; Quaranta, P.; Spezia, P. G.; Freer, G.; Lenzi, P.; Fornai, F.; Piomelli, D.; Pistello, M.

10.1101/2022.02.08.479661 — microbiology — Posted on 2022-02-09

2552 Comparative transcriptomics unveil distinctive metabolic pathway of phosphonate utilization by diatom Phaeodactylum tricornutum

Shu, H.; You, Y.; Wang, H.; Wang, J.; Li, L.; Lin, X.; Ma, J.

10.1101/2022.02.09.479573 — microbiology — Posted on 2022-02-09

2553 A bacterial pan-genome makes gene essentiality strain-dependent and evolvable

Rosconi, F.; Rudmann, E.; Li, J.; Surujon, D.; Anthony, J.; Frank, M.; Jones, D. S.; Rock, C.; Rosch, J. W.; Johnston, C. D.; van Opijnen, T.

10.1101/2022.02.08.479609 — microbiology — Posted on 2022-02-09

2554 Pectobacterium colocasium sp. nov. isolated from taro (Colocasia esculenta)

Klair, D.; Arizala, D.; Dobhal, S.; Boluk, G.; Alvarez, A. M.; Arif, M.

10.1101/2022.02.08.479620 — microbiology — Posted on 2022-02-09

2555 Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23

Dass, S.; Mather, M. W.; Ling, L.; Vaidya, A. B.; Ke, H.

10.1101/2022.02.09.479728 — microbiology — Posted on 2022-02-09

2556 SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Hall, R.; Guedan, A.; Yap, M. W.; Young, G. R.; Harvey, R.; Stoye, J. P.; Bishop, K. N.

10.1101/2022.02.08.479664 — microbiology — Posted on 2022-02-09

2557 A phasevarion controls multiple virulence traits, including expression of vaccine candidates, in Streptococcus pneumoniae

Phillips, Z. N.; Trappetti, C.; Van Den Bergh, A.; Martin, G.; Calcutt, A.; Ozberk, V.; Guillon, P.; Pandey, M.; von Itzstein, M.; Swords, W. E.; Paton, J. C.; Jennings, M. P.; Atack, J. M.

10.1101/2022.02.08.479631 — microbiology — Posted on 2022-02-09

2558 Termination factor Rho mediates transcriptional reprogramming of Bacillus subtilis stationary phase.

Bidnenko, V.; Nicolas, P.; Guerin, C.; Derozier, S.; Chastanet, A.; Dairou, J.; Redko-Hamel, Y.; Jules, M.; Bidnenko, E.

10.1101/2022.02.09.479721 — microbiology — Posted on 2022-02-09

2559 The efficacy of commercial decontamination agents differs between standardised test settings and real-world usage for a variety of bacterial species

Uy, B.; Read, H.; van de Pas, S.; Marnane, R.; Casu, F.; Swift, S.; Wiles, S.

10.1101/2022.02.08.479643 — microbiology — Posted on 2022-02-09

2560 Auto-Immunoproteomics Analysis of COVID-19 ICU Patients Revealed Increased Levels of Autoantibodies Related to Male Reproductive System

Schmidt, F.; Abdesselem, H. B.; Suhre, K.; Sohail, m. u.; Al-Nesf, M.; Bensmail, I.; Mashod, F.; Sarwath, H.; Bernhardt, J.; Tan, T.-M.; Morris, P. E.; Schenck, E. J.; Price, D.; Vaikath, N.; Mohamed-Ali, V.; Al-Maadheedh, M.; Arredouani, A.; Decock, J. V.; Blackburn, J.; Choi, A. M. K.; El-Agnaf, O. M. A.

10.1101/2022.02.09.479669 — immunology — Posted on 2022-02-09

2561 Motif elucidation in ChIP-seq datasets with a knockout control

Denisko, D.; Viner, C.; Hoffman, M. M.

10.1101/721720 — bioinformatics — Posted on 2022-02-09

2562 The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3

Hall, D.; Giaimo, B. D.; Park, S.-S.; Hemmer, W.; Friedrich, T.; Ferrante, F.; Bartkuhn, M.; Yuan, Z.; Oswald, F.; Borggrefe, T.; Rual, J.; Kovall, R.

10.1101/2022.02.09.479311 — biochemistry — Posted on 2022-02-09

2563 Flavobacterium johnsoniae Tyrosine Ammonia Lyase (FjTAL) in-silico Structure Prediction and Molecular Docking to L-tyrosine, p-coumaric acid (pHCA) and Caffeic Acid

Mousavi Majd, S.

10.1101/2022.02.09.479702 — biochemistry — Posted on 2022-02-09

2564 Narrow transmission bottlenecks and limited within-host viral diversity during a SARS-CoV-2 outbreak on a fishing boat

Hannon, W. H.; Roychoudhury, P.; Xie, H.; Shrestha, L.; Addetia, A.; Jerome, K. R.; Greninger, A. L.; Bloom, J. D.

10.1101/2022.02.09.479546 — evolutionary biology — Posted on 2022-02-09

2565 A Split-GAL4 screen identifies novel sleep-promoting neurons in the Ventral Nerve Cord of Drosophila

Jones, J. D.; Holder, B. L.; Eiken, K. R.; Vogt, A.; Velarde, A. I.; Elder, A. J.; McEllin, J. A.; Dissel, S.

10.1101/2022.02.02.478882 — neuroscience — Posted on 2022-02-09

2566 Measuring competitive exclusion in non-small cell lung cancer

Farrokhian, N.; Maltas, J.; Dinh, M.; Durmaz, A.; Ellsworth, P.; Hitomi, M.; McClure, E.; Marusyk, A.; Kaznatcheev, A.; Scott, J. G.

10.1101/2020.09.18.303966 — cancer biology — Posted on 2022-02-09

2567 Flexible control of Pavlovian-instrumental transfer based on expected reward value

Marshall, A. T.; Ostlund, S. B.; Halbout, B.; Munson, C.; Hutson, C.

10.1101/2021.04.08.438512 — animal behavior and cognition — Posted on 2022-02-09

2568 Functional substitutability of native herbivores by livestock for long-term soil carbon sequestration depends on microbial decomposers.

Roy, S.; Bagchi, S.

10.1101/2022.02.07.479355 — ecology — Posted on 2022-02-09

2569 Spontaneous and ART-induced large offspring syndrome: similarities and differences in DNA methylome

Li, Y.; Sena-Lopes, J.; Coy-Fuster, P.; Rivera, R. M.

10.1101/2022.02.07.479430 — developmental biology — Posted on 2022-02-09

2570 Aerosol Formation During Processing of Potentially Infectious Samples on Roche Immunochemistry Analyzers (cobas e analyzers) and in an End-to-End Laboratory Workflow to Model SARS-CoV-2 Infection Risk for Laboratory Operators

Burghardt, G. V.; Eckl, M.; Huether, D.; Larbolette, O. H. D.; Lo Faso, A.; Ofenloch-Haehnle, B. R.; Riesch, M. A.; Herb, R. A.

10.1101/2022.02.08.479519 — molecular biology — Posted on 2022-02-09

2571 The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

Miorin, L.; Mire, C. E.; Ranjbar, S.; Hume, A. J.; Huang, J.; Crossland, N. A.; White, K. M.; Laporte, M.; Kehrer, T.; Haridas, V.; Moreno, E.; Nambu, A.; Jangra, S.; Cupic, A.; Dejosez, M.; Abo, K. A.; Tseng, A. E.; Werder, R. B.; Rathnasinghe, R.; Mutetwa, T.; Ramos, I.; Sainz de Aja, J.; Garcia de Alba Rivas, C.; Schotsaert, M.; Corley, R. B.; Falvo, J. V.; Fernandez-Sesma, A.; Kim, C.; Rossignol, J.-F.; Wilson, A. A.; Zwaka, T.; Kotton, D. N.; Mühlberger, E.; García-Sastre, A.; Goldfeld, A. E.

10.1101/2022.02.08.479634 — immunology — Posted on 2022-02-09

2572 Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release

Chan, M.; Holland, E.; Gujral, T.

10.1101/2022.02.07.479443 — immunology — Posted on 2022-02-09

2573 Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN

Spacek, M. A.; Crombie, D.; Bauer, Y.; Born, G.; Liu, X.; Katzner, S.; Busse, L.

10.1101/776237 — neuroscience — Posted on 2022-02-09

2574 Trimeric Photosystem I facilitates energy transfer from phycobilisomes in Synechocystis sp. PCC 6803

Akhtar, P.; Biswas, A.; Balog-Vig, F.; Domonkos, I.; Kovacs, L.; Lambrev, P. H.

10.1101/2021.10.25.465751 — biophysics — Posted on 2022-02-09

2575 Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

Zhao, H.; Nguyen, A.; Wu, D.; Li, Y.; Hassan, S. A.; Chen, J.; Shroff, H.; Piszczek, G.; Schuck, P.

10.1101/2022.02.08.479556 — biophysics — Posted on 2022-02-09

2576 Designing effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains: an in silico approach

Madanagopal, P.; Muthukumar, H.; Thiruvengadam, K.

10.1101/2022.02.08.479559 — bioinformatics — Posted on 2022-02-09

2577 The mechanism of RNA capping by SARS-CoV-2

Park, G. J.; Osinski, A.; Hernandez, G.; Eitson, J.; Majumdar, A.; Tonelli, M.; Henzler-Wildman, K.; Pawlowski, K.; Chen, Z.; Li, Y.; Schoggins, J.; Tagliabracci, V. S.

10.1101/2022.02.07.479471 — biochemistry — Posted on 2022-02-09

2578 The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

Correy, G. J.; Kneller, D. W.; Phillips, G.; Pant, S.; Russi, S.; Cohen, A. E.; Meigs, G.; Holton, J. M.; Gahbauer, S.; Thompson, M. C.; Ashworth, A.; Coates, L.; Kovalevsky, A.; Meilleur, F.; Fraser, J. S.

10.1101/2022.02.07.479477 — biochemistry — Posted on 2022-02-09

2579 Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

Ying, B.; Scheaffer, S. M.; Whitener, B.; Liang, C.-Y.; Dmytrenko, O.; Mackin, S.; Wu, K.; Lee, D.; Avena, L. E.; Chong, Z.; Case, J. B.; Ma, L.; Kim, T.; Sein, C.; Woods, A.; Carfi, A.; Elbashir, S. M.; Edwards, D. K.; Thackray, L. B.; Diamond, M. S.

10.1101/2022.02.07.479419 — microbiology — Posted on 2022-02-09

2580 Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages

Iketani, S.; Liu, L.; Guo, Y.; Liu, L.; Huang, Y.; Wang, M.; Luo, Y.; Yu, J.; Yin, M. T.; Sobieszczyk, M. E.; Huang, Y.; Wang, H. H.; Sheng, Z.; Ho, D. D.

10.1101/2022.02.07.479306 — microbiology — Posted on 2022-02-09

2581 Neutralization Of SARS-CoV-2 Variants By A Human Polyclonal Antibody Therapeutic (COVID-HIG, NP-028) With High Neutralizing Titers To SARS-CoV-2

Toth, D.

10.1101/2022.01.27.478053 — immunology — Posted on 2022-02-09

2582 Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

Walls, A. C.; VanBlargan, L. A.; Wu, K.; Choi, A.; Navarro, M. J.; Lee, D.; Avena, L.; Berrueta, D. M.; Pham, M. N.; Elbashir, S.; Miranda, M. C.; Kepl, E.; Johnson, M.; Blackstone, A.; Sprouse, K. R.; Fiala, B.; O'Connor, M. A.; Brunette, N.; S Arunachalam, P.; Shirreff, L.; Rogers, K. A.; Carter, L.; Fuller, D. H.; Villinger, F. J.; Pulendran, B.; Diamond, M. S.; Edwards, D. K.; King, N. P.; Veesler, D.

10.1101/2022.02.07.479468 — immunology — Posted on 2022-02-09

2583 NMNAT2 is the major NAD+ provider for vesicular glycolysis generating on-board energy for fast axonal transport cargos

Yang, S.; Niou, Z.-X.; LaMar, J.; Enriquez, A.; Huang, J.-Y.; Tennessen, J.; Rangaraju, V.; Lu, H.-C.

10.1101/2022.02.06.479307 — neuroscience — Posted on 2022-02-09

2584 Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology

Banks, M. I.; Krause, B. M.; Berger, D. G.; Campbell, D. I.; Boes, A. D.; Bruss, J. E.; Kovach, C. K.; Kawasaki, H.; Steinschneider, M.; Nourski, K. V.

10.1101/2022.02.06.479292 — neuroscience — Posted on 2022-02-09

2585 Anatomical connectivity profile development constrains medial-lateral topography in the dorsal prefrontal cortex

Li, W.; Shi, W.; Wang, H.; Li, J.; Cui, Y.; Li, K.; Cheng, L.; Lu, Y.; Ma, L.; Chu, C.; Song, M.; Yang, Z.; Banaschewski, T.; Bokde, A. L. W.; Desrivieres, S.; Flor, H.; Grigis, A.; Garavan, H.; Gowland, P. A.; Walter, H.; Brühl, R.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; Nees, F.; Orfanos, D. P.; Lemaitre, H.; Paus, T.; Poustka, L.; Hohmann, S.; Millenet, S.; Fröhner, J. H.; Robinson, L.; Smolka, M. N.; Winterer, J.; Whelan, R.; Schumann, G.; Fan, L.; Jiang, T.

10.1101/2022.02.07.479322 — neuroscience — Posted on 2022-02-09

2586 Automatic identification of intestinal parasites in reptiles using microscopic stool images and convolutional neural networks

Grijalva, F.; Nunez, B.; Nunez, A.; Parra, C.; Perez, N.; Benitez, D.

10.1101/2022.02.06.479317 — zoology — Posted on 2022-02-09

2587 Novel methodology for localizing and studying the insect dorsal rim area morphology in 2D and 3D

Jie, V. W.; Miettinen, A.; Baird, E.

10.1101/2022.02.07.479135 — zoology — Posted on 2022-02-09

2588 Taxonomic practice, creativity, and fashion: What's in a spider name?

Mammola, S.; Viel, N.; Amiar, D.; Mani, A.; Herve, C.; Heard, S. B.; Fontaneto, D.; Petillon, J.

10.1101/2022.02.06.479275 — scientific communication and education — Posted on 2022-02-09

2589 Fate tracing reveals differences between Reelin+ HSCs and Desmin+ HSCs in activation, migration, and proliferation activities

Chen, N.; Liu, S.; Qin, D.; Guan, D.; Chen, Y.; Hou, C.; Zheng, S.; Wang, L.; Chen, X.; Zhang, L.

10.1101/2022.02.06.479312 — pathology — Posted on 2022-02-09

2590 Bayesian Additive Regression Trees for Genotype by Environment Interaction Models

Sarti, D. A.; Prado, E. B.; Inglis, A.; dos Santos, A. A. L.; Hurley, C.; Moral, R. d. A.; Parnell, A.

10.1101/2021.05.07.442731 — bioinformatics — Posted on 2022-02-09

2591 Spatio-temporal, optogenetic control of gene expression in organoids

Legnini, I.; Emmenegger, L.; Zappulo, A.; Wurmus, R.; Oliveras Martinez, A.; Cerda Jara, C.; Boltengagen, A.; Hessler, T.; Mastrobuoni, G.; Rybak-Wolf, A.; Kempa, S.; Zinzen, R. P.; Woehler, A.; Rajewsky, N.

10.1101/2021.09.26.461850 — bioengineering — Posted on 2022-02-09

2592 Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes

Lalli, M. A.; Yen, A.; Thopte, U.; Dong, F.; Moudgil, A.; Chen, X.; Milbrandt, J.; Dougherty, J. D.; Mitra, R. D.

10.1101/2021.04.15.439516 — genomics — Posted on 2022-02-09

2593 An atlas of gene expression variation across the Caenorhabditis elegans species

Zhang, G.; Roberto, N. M.; Lee, D.; Hahnel, S. R.; Andersen, E. C.

10.1101/2022.02.06.479320 — genetics — Posted on 2022-02-09

2594 Genotypic Sex Determination Systems could be Adaptations to Extreme Temperature Environments in Reptiles and to Endothermy in Mammals and Birds

Ferrando-Bernal, M.; Lao, O.

10.1101/2022.02.07.479281 — evolutionary biology — Posted on 2022-02-09

2595 Pairing-dependent plasticity in a dissected fly brain is input-specific and requires synaptic CaMKII enrichment and nighttime sleep

Adel, M.; Chen, N.; Zhang, Y.; Reed, M. L.; Quasney, C.; Griffith, L. C.

10.1101/2022.02.08.479633 — neuroscience — Posted on 2022-02-09

2596 Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit

Nguyen, E.; Smith, K.; Cramer, N. P.; Holland, R.; Bleimeister, I.; Flores-Felix, K.; Silberberg, H.; Keller, A.; Le Pichon, C.; Ross, S. E.

10.1101/2022.02.08.479623 — neuroscience — Posted on 2022-02-09

2597 Ascending neurons convey behavioral state to integrative sensory and action selection centers in the brain

Chen, C.-L.; Aymanns, F.; Minegishi, R.; Matsuda, V.; Talabot, N.; Gunel, S.; Dickson, B. J.; Ramdya, P.

10.1101/2022.02.09.479566 — neuroscience — Posted on 2022-02-09

2598 All-optical manipulation of the Drosophila olfactory system.

Zanon, M.; Zanini, D.; Haase, A.

10.1101/2022.02.08.479558 — neuroscience — Posted on 2022-02-09

2599 Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy

Miller, A. L.; Fuller-Carter, P. I.; Masarini, K.; Samardzija, M.; Carter, K. W.; Rashwan, R.; Brunet, A. A.; Chopra, A.; Ram, R.; Grimm, C.; Ueffing, M.; Carvalho, L. S.; Trifunovic, D.

10.1101/2022.02.07.479069 — neuroscience — Posted on 2022-02-09

2600 BlotIt - Optimal alignment of western blot and qPCR experiments

Kemmer, S.; Bang, S.; Rosenblatt, M.; Timmer, J.; Kaschek, D.

10.1101/2022.02.09.479689 — systems biology — Posted on 2022-02-09

2601 CameraTrapDetectoR: Automatically detect, classify, and count animals in camera trap images using artificial intelligence

Tabak, M. A.; Falbel, D.; Hamzeh, T.; Brook, R. K.; Goolsby, J. A.; Zoromski, L. D.; Boughton, R. K.; Snow, N. P.; VerCauteren, K. C.; Miller, R. S.

10.1101/2022.02.07.479461 — ecology — Posted on 2022-02-09

2602 Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription

Fernandes, G.; Tran, H.; Andrieu, M.; Diaw, Y.; Perez Romero, C.; Fradin, C.; Coppey, M.; Walczak, A. M.; Dostatni, N.

10.1101/2021.09.06.459125 — developmental biology — Posted on 2022-02-09

2603 Obesity affects mitochondrial metabolism and proliferative potential of equine endometrial progenitor cells.

Smieszek, A.; Marcinkowska, K.; Pielok, A.; Sikora, M.; Valihrach, L.; Carnevale, E.; Marycz, K.

10.1101/2021.12.02.470884 — cell biology — Posted on 2022-02-09

2604 Neutrophils degranulate GAG-containing proteoglycofili, which block Shigella growth and degrade virulence factors

Andre, A.; Barroso, M. V.; Skerniskyte, J.; Siegwald, M.; Paul, V.; Debande, L.; Ridley, C.; Svahn, I.; Rigaud, S.; Tinevez, J.-Y.; Vives, R.; Sansonetti, P.; Marteyn, B. S.

10.1101/2022.02.08.479570 — immunology — Posted on 2022-02-09

2605 Astrocytes regulate inhibition in Fragile X Syndrome

Rais, M.; Kulinich, A. O.; Wagner, V.; Woodard, W.; Shuai, X. S.; Suley, S. N.; Kokash, J.; Castren, M.; Razak, K.; Ethell, I.

10.1101/2022.02.08.479618 — neuroscience — Posted on 2022-02-09

2606 Understanding Hybrid Lipid-Polymer Gene Delivery Nanoparticle Assembly with Fluorescence Cross Correlation Spectroscopy

Paris, J. L.; Gaspar, R.; Coelho, F.; De Beule, P.; Silva, B. F. B.

10.1101/2022.02.06.479316 — biophysics — Posted on 2022-02-09

2607 What do Functional Synchronization Networks Indicate About Underlying Structure and System Dynamics? A network theory study in the islet

Briggs, J. K.; Kravets, V.; Dwulet, J. M.; Benninger, R. K.

10.1101/2022.02.06.479331 — biophysics — Posted on 2022-02-09

2608 Data-driven models of optimal chromatic coding in the outer retina

Ramirez, L.; Dickman, R.

10.1101/2022.02.07.479405 — biophysics — Posted on 2022-02-09

2609 Optimal pathways control fixation of multiple mutations during cancer initiation

Teimouri, H.; Spaulding, C.; Kolomeisky, A. B.

10.1101/2022.02.07.479413 — biophysics — Posted on 2022-02-09

2610 De novo mass spectrometry peptide sequencing with a transformer model

Yilmaz, M.; Fondrie, W. E.; Bittremieux, W.; Oh, S.; Noble, W. S.

10.1101/2022.02.07.479481 — bioinformatics — Posted on 2022-02-09

2611 psntools - a Python package for protein structure network analysis

Sora, V.; Tiberti, M.; Papaleo, E.

10.1101/2022.02.07.479254 — bioinformatics — Posted on 2022-02-09

2612 Influence of earlier human activity on gut microbiota and immune responses of Darwin's finches in the Galapagos Islands

Bygrave, J.; Zylberberg, M. A.; Addesso, A.; Knutie, S. A.

10.1101/2022.02.07.479384 — ecology — Posted on 2022-02-09

2613 Coupling comprehensive pesticide-wide association study to iPSC dopaminergic screening identifies and classifies Parkinson-relevant pesticides

Paul, K. C.; Krolewski, R. C.; Moreno, E. L.; Blank, J.; Holton, K. M.; Ahfeldt, T. D.; Furlong, M.; Yu, Y.; Cockburn, M.; Thompson, L. K.; Bronstein, J.; Rubin, L. L.; Khurana, V.; Ritz, B.

10.1101/2022.02.06.479305 — neuroscience — Posted on 2022-02-09

2614 Expression analysis of Huntington disease mouse models reveals robust striatum disease signatures

Obenauer, J. C.; Chen, J.; Andreeva, V.; Aaronson, J. S.; Lee, R.; Caricasole, A.; Rosinski, J.

10.1101/2022.02.04.479180 — neuroscience — Posted on 2022-02-09

2615 Aging clocks, entropy, and the limits of age-reversal

Tarkhov, A. E.; Denisov, K. A.; Fedichev, P. O.

10.1101/2022.02.06.479300 — systems biology — Posted on 2022-02-09

2616 Sub-10 nm fluorescence imaging

Sauer, M.; Helmerich, D. A.; Beliu, G.; Taban, D.; Meub, M.; Kuhlemann, A.; Doose, S.; Streit, M.

10.1101/2022.02.08.479592 — biophysics — Posted on 2022-02-09

2617 Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

Inada, M.; Iwamoto, M.; Yoshida, N.; Oiki, S.; Matsumori, N.

10.1101/2022.02.08.479071 — biophysics — Posted on 2022-02-09

2618 Foldseek: fast and accurate protein structure search

van Kempen, M.; Kim, S.; Tumescheit, C.; Mirdita, M.; Soeding, J.; Steinegger, M.

10.1101/2022.02.07.479398 — bioinformatics — Posted on 2022-02-09

2619 Very small spontaneous structural mutation rate in green algae

Leger-Pigout, M.; Krasovec, M.

10.1101/2022.02.09.479524 — evolutionary biology — Posted on 2022-02-09

2620 Impact of cell culture on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells

Alysandratos, K.; Garcia de Alba Riva, C.; Yao, C.; Pessina, P.; Villacorta-Martin, C.; Huang, J.; Hix, O. T.; Minakin, K.; Konda, B.; Stripp, B. R.; Kim, C. F.; Kotton, D. N.

10.1101/2022.02.08.479591 — cell biology — Posted on 2022-02-09

2621 Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Lindoso, R. S.; Yengej, F. A. Y.; Voellmy, F.; Altelaar, M.; Juncosa, E. M.; Tsikari, T.; Ammerlaan, C. M. E.; Van Balkom, B. W. M.; Verhaar, M. C.; Masereeuw, R.

10.1101/2022.02.08.479621 — cell biology — Posted on 2022-02-09

2622 Live cell biosensors based on the fluorescence lifetime of environment-sensing dyes

Mehl, B.; Li, L.; Hinde, E.; Liu, B.; MacNevin, C. J.; Hsu, C.-W.; Gratton, E.; Hahn, K. M.

10.1101/2022.02.08.479035 — cell biology — Posted on 2022-02-09

2623 Myosin 10 supports mitotic spindle bipolarity by promoting PCM integrity and supernumerary centrosome clustering

Yim, Y.-I.; Pedrosa, A.; Wu, X.; Cheney, R. E.; Hammer, J.

10.1101/2022.02.08.479580 — cell biology — Posted on 2022-02-09

2624 Combination of structural and functional connectivity explains unique variation in specific domains of cognitive function.

Litwinczuk, M. C.; Trujillo-Barreto, N.; Muhlert, N.; Cloutman, L.; Woollams, A.

10.1101/2021.10.20.463183 — neuroscience — Posted on 2022-02-09

2625 Perception of RNA Nanotechnology among students and recommendations towards improved educational outreach

Kozlov, S.

10.1101/2022.02.06.479286 — scientific communication and education — Posted on 2022-02-09

2626 A paternal bias in germline mutation is widespread across amniotes and can arise independently of cell divisions

de Manuel, M.; Wu, F. L.; Przeworski, M.

10.1101/2022.02.07.479417 — evolutionary biology — Posted on 2022-02-09

2627 Partitioning variance in reproductive success, within years and across lifetimes

Waples, R. S.

10.1101/2022.02.08.479606 — evolutionary biology — Posted on 2022-02-09

2628 Mother centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly

Wong, S.-S.; Wilmott, Z. M.; Saurya, S.; Alvarez-Rodrigo, I.; Zhou, F. Y.; Chau, K.-Y.; Goriely, A.; Raff, J.

10.1101/2021.10.26.465695 — cell biology — Posted on 2022-02-09

2629 Relative enrichment - a density-based colocalization measure for single-molecule localization microscopy

Ejdrup, A. L.; Lycas, M. D.; Lorenzen, N.; Konomi, A.; Herborg, F.; Madsen, K. L.; Gether, U.

10.1101/2022.02.08.479535 — cell biology — Posted on 2022-02-09

2630 A Microtubule Mechanostat Enables Cells to Navigate Confined Environments

Ju, R. J.; Falconer, A. D.; Tang, C. K. X.; Dean, K. M.; Fiolka, R. P.; Sester, D. P.; Nobis, M.; Timpson, P.; Lomakin, A. J.; White, M. D.; Oelz, D. B.; Haass, N. K.; Stehbens, S. J.

10.1101/2022.02.08.479516 — cell biology — Posted on 2022-02-09

2631 Matchtigs: minimum plain text representation of kmer sets

Schmidt, S.; Khan, S.; Alanko, J.; Tomescu, A. I.

10.1101/2021.12.15.472871 — bioinformatics — Posted on 2022-02-09

2632 The evolution of novel biotic interactions at ecological margins in response to climate change involves alleles from across the geographical range of the UK Brown Argus butterfly

de Jong, M.; Janzen van Rensburg, A.; Whiteford, S.; Yung, C.; Beaumont, M. A.; Jiggins, C.; Bridle, J.

10.1101/2022.02.07.479435 — evolutionary biology — Posted on 2022-02-09

2633 The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

Werner, E.; Gokhale, A.; Ackert, M.; Xu, C.; Wen, Z.; Roberts, A. M.; Roberts, B. R.; Vrailas-Mortimer, A. R.; Crocker, A. J.; Faundez, V.

10.1101/2022.01.04.474973 — cell biology — Posted on 2022-02-09

2634 Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at the base of primary cilia and suppresses ciliary elongation

Morthorst, S. K.; Nielsen, C.; Farinelli, P.; Anvarian, Z.; Rasmussen, C. B. R.; Serra-Marques, A.; Grigoriev, I.; Altelaar, M.; Furstenberg, N.; Ludwig, A.; Akhmanova, A.; Christensen, S. T.; Pedersen, L. B.

10.1101/2021.10.14.464392 — cell biology — Posted on 2022-02-09

2635 Azole resistance associated regulatory motifs within the promoter of cyp51A in Aspergillus fumigatus

Kühbacher, A.; Peiffer, M.; Hortschansky, P.; Merschak, P.; Bromley, M. J.; Haas, H.; Brakhage, A.; Gsaller, F.

10.1101/2022.02.07.479494 — molecular biology — Posted on 2022-02-09

2636 De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

Tetreau, G.; Sawaya, M. R.; De Zitter, E.; Andreeva, E. A.; Banneville, A.-S.; Schibrowsky, N.; Coquelle, N.; Brewster, A. S.; Grunbein, M. L.; Nass-Kovacs, G.; Hunter, M. S.; Kloos, M.; Sierra, R. G.; Schiro, G.; Qiao, P.; Stricker, M.; Bideshi, D.; Young, I. D.; Zala, N.; Engilberge, S.; Gorel, A.; Signor, L.; Teulon, J.-M.; Hilpert, M.; Foucar, L.; Bielecki, J.; de Wijn, R.; Sato, T.; Kirkwood, H.; Bean, R.; Letrun, R.; Batyuk, A.; Snigireva, I.; Fenel, D.; Schubert, R.; Canfield, E. J.; Alba, M. M.; Laporte, F.; Despres, L.; Bacia, M.; Roux, A.; Chapelle, C.; Riobe, F.; Maury, O.; Ling, W.

10.1101/2021.12.15.472578 — molecular biology — Posted on 2022-02-09

2637 Light/dark and temperature cycling modulate metabolic electron flow in Pseudomonas aeruginosa biofilms

Kahl, L. J.; Eckartt, K.; Morales, D. K.; Price-Whelan, A.; Dietrich, L. E. P.

10.1101/2022.02.07.479496 — microbiology — Posted on 2022-02-09

2638 Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog

Biou, V.; Adaixo, R. J. D.; Chami, M.; Coureux, P.-D.; Laurent, B.; Ntsogo Enguene, V. Y.; Cardoso de Amorim, G.; Izadi-Pruneyre, N.; Malosse, C.; Chamot-Rooke, J.; Stahlberg, H.; Delepelaire, P.

10.1101/2021.04.21.440815 — microbiology — Posted on 2022-02-09

2639 Individual variation in brain structural-cognition relationships in aging

Patel, R.; Mackay, C. E.; Jansen, M. G.; Devenyi, G.; O'Donoghue, M. C.; Kivimäki, M.; Singh-Manoux, A.; Zsoldos, E.; Ebmeier, K. P.; Chakravarty, M.; Suri, S.

10.1101/2021.02.19.431732 — neuroscience — Posted on 2022-02-09

2640 A Proposal for Finite But Unbounded Human Lifetimes

Huang, F.; Maller, R.; Milholland, B.; Ning, X.

10.1101/2022.01.07.474862 — systems biology — Posted on 2022-02-09

2641 Reconstructing Kinetic Models for Dynamical Studies of Metabolism using Generative Adversarial Networks

Choudhury, S.; Moret, M.; Salvy, P.; Weilandt, D.; Hatzimanikatis, V.; Miskovic, L.

10.1101/2022.01.06.475020 — systems biology — Posted on 2022-02-09

2642 Optimal density of biological cells

Pang, T. Y.; Lercher, M.

10.1101/2020.11.18.388744 — biophysics — Posted on 2022-02-09

2643 Construction of in silico protein-protein interaction networks across different topologies using machine learning

Lannelongue, L.; Inouye, M.

10.1101/2022.02.07.479382 — bioinformatics — Posted on 2022-02-09

2644 scanMiR: a biochemically-based toolkit for versatile and efficient microRNA target prediction

Soutschek, M.; Gross, F.; Schratt, G.; Germain, P.-L.

10.1101/2021.06.16.448293 — bioinformatics — Posted on 2022-02-09

2645 BlotIt - Optimal alignment of western blot and qPCR experiments

Kemmer, S.; Bang, S.; Rosenblatt, M.; Timmer, J.; Kaschek, D.

10.1101/2022.02.09.479689 — bioinformatics — Posted on 2022-02-09

2646 Artificial reefs geographical location matters more than shape, age and depth for sessile invertebrate colonization in the Gulf of Lion (NorthWestern Mediterranean Sea)

blouet, s.; Guizien, K.; Bramanti, l.

10.1101/2021.10.08.463669 — ecology — Posted on 2022-02-09

2647 Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.

Burton, J.; Siller-Farfan, J. A.; Pettmann, J.; Salzer, B.; Kutuzov, M.; van der Merwe, P. A.; Dushek, O.

10.1101/2021.10.26.465853 — immunology — Posted on 2022-02-09

2648 Progressive alterations in polysomal architecture in a mouse model of Huntington's disease

Martin-Solana, E.; Diaz-Lopez, I.; Ventoso, I.; Fernandez, J.-J.; Fernandez-Fernandez, M. R.

10.1101/2021.12.13.472357 — neuroscience — Posted on 2022-02-09

2649 Distinct Processing of Selection and Execution Errors in Neural Signatures of Outcome Monitoring

Mushtaq, F.; McDougle, S. D.; Craddock, M. P.; Parvin, D.; Brookes, J.; Schaefer, A.; Mon-Williams, M.; Taylor, J. A.; Ivry, R. B.

10.1101/853317 — neuroscience — Posted on 2022-02-09

2650 Differential effects of prediction error and adaptation along the auditory cortical hierarchy during deviance processing

Schlossmacher, I.; Dilly, J.; Protmann, I.; Hofmann, D.; Dellert, T.; Roth-Paysen, M.-L.; Moeck, R.; Bruchmann, M.; Straube, T.

10.1101/2020.10.19.339234 — neuroscience — Posted on 2022-02-09

2651 Agrochemical control of gene expression using evolved split RNA polymerase

Yuan, Y.; Miao, J.

10.1101/2021.05.03.442273 — synthetic biology — Posted on 2022-02-09

2652 Effects of cryo-EM cooling on structural ensembles

Bock, L. V.; Grubmüller, H.

10.1101/2021.10.08.463658 — biophysics — Posted on 2022-02-09

2653 Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

Cada, A. K.; Remec Pavlin, M.; Castillo, J. P.; Tong, A. B.; Larsen, K. P.; Ren, X.; Yokom, A. L.; Tsai, F.-C.; Shiah, J.; Bassereau, P.; Bustamante, C. J.; Hurley, J. H.

10.1101/2022.02.03.479062 — biophysics — Posted on 2022-02-09

2654 The usefulness of sparse k-means in metabolomics data: Anexample from breast cancer data

Goudo, M.; Sugimoto, M.; Hiwa, S.; Hiroyasu, T.

10.1101/2022.02.05.479235 — bioinformatics — Posted on 2022-02-09

2655 Creativity in Verbal Associations is Linked to Semantic Control

Krieger-Redwood, K.; Steward, A.; Gao, Z.; Wang, X.; Halai, A.; Smallwood, J.; Jefferies, E.

10.1101/2022.02.08.479385 — neuroscience — Posted on 2022-02-09

2656 Capacity and tradeoffs in neural encoding of concurrent speech during Selective and Distributed Attention

Kaufman, M.; Zion Golumbic, E.

10.1101/2022.02.08.479628 — neuroscience — Posted on 2022-02-09

2657 An AI-assisted Tool For Efficient Prostate Cancer Diagnosis

Oner, M. U.; Ng, M. Y.; Giron, D. M.; Xi, C. E. C.; Xiang, L. A. Y.; Singh, M.; Yu, W.; Sung, W.-K.; Wong, C. F.; Lee, H. K.

10.1101/2022.02.06.479283 — cancer biology — Posted on 2022-02-09

2658 Unsupervised encoding selection through ensemble pruning for biomedical classification

Spaenig, S.; Michel, A.; Heider, D.

10.1101/2022.02.06.479282 — bioinformatics — Posted on 2022-02-09

2659 Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

Huang, Y.; Liu, X.; Wang, H.-Y.; Chen, J.-Y.; Zhang, X.; Li, Y.; Lu, Y.; Dong, Z.; Liu, K.; Wang, Z.; Wang, Q.; Fan, G.; Zou, J.; Liu, S.; Shao, C.

10.1101/2022.02.06.479276 — immunology — Posted on 2022-02-09

2660 A Fast And Intuitive Method For Calculating Dynamic Network Reconfiguration And Node Flexibility

Chinichian, N.; Kruschwitz, J.; Reinhardt, P.; Palm, M.; Wellan, S.; Erk, S.; Heinz, A.; Walter, H.; Veer, I.

10.1101/2022.02.06.479287 — neuroscience — Posted on 2022-02-09

2661 Glypican-3 (GPC3) is associated with MCPyV-negative status and impaired outcome in Merkel Cell Carcinoma

Muralidharan, S.; Kervarrec, T.; Weiss, G. J.; Samimi, M.

10.1101/2022.02.06.479301 — cancer biology — Posted on 2022-02-09

2662 Combination of an inject-and-transfer system for serial femtosecond crystallography

Lee, K.; Kim, J.; Baek, S.; Park, J.; Park, S.; Lee, J.-L.; Chung, W. K.; Cho, Y.; Nam, K. H.

10.1101/2022.02.08.479470 — biophysics — Posted on 2022-02-09

2663 A mitochondrial blood-based patient stratification candidate biomarker for Parkinson's disease

Qi, R.; Sammler, E.; Gonzalez-Hunt, C. P.; Pena, N.; Rouanet, J. P.; Goodson, S.; Fuzzati, M.; Blandini, F.; Erickson, K. I.; Weinstein, A. M.; Padmanabhan, S.; Fox BioNet (FBN) investigators, ; Tonelli, F.; Alessi, D. R.; Shiva, S.; Sanders, L. H.

10.1101/2022.02.07.479309 — neuroscience — Posted on 2022-02-09

2664 Construction of in silico protein-protein interaction networks across different topologies using machine learning

Lannelongue, L.; Inouye, M.

10.1101/2022.02.07.479382 — bioinformatics — Posted on 2022-02-08

2665 Population differentiation of polygenic score predictions under stabilizing selection

Yair, S.; Coop, G.

10.1101/2021.09.10.459833 — evolutionary biology — Posted on 2022-02-08

2666 Clinically Relevant Pathogens on Surfaces Display Differences in Survival and Transcriptomic Response in Relation to Probiotic and Traditional Cleaning Strategies

Hu, J.; Shuai, W.; Sumner, J. T.; Moghadam, A. A.; Hartmann, E. M.

10.1101/2022.01.11.475867 — microbiology — Posted on 2022-02-08

2667 Profiling the molecular signature of Satellite Glial Cells at the single cell level reveals high similarities between rodent and human

Avraham, O.; Chamessian, A.; Feng, R.; Yang, L.; Halevi, A. E.; Moore, A. M.; Gereau, R. W.; Cavalli, V.

10.1101/2021.04.17.440274 — neuroscience — Posted on 2022-02-08

2668 Different forms of variability could explain a difference between human and rat decision making

Nguyen, Q. N.; Reinagel, P.

10.1101/2020.01.05.895268 — neuroscience — Posted on 2022-02-08

2669 Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

Liu, Z.; Chen, T.; Zhang, S.; Yang, T.; Gong, Y.; deng, H.-W.; Bai, D.; Tian, W.; Chen, Y.

10.1101/2021.01.14.426702 — physiology — Posted on 2022-02-08

2670 Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia

Park, C. Y.; Stranahan, A. W.; Berezniuk, I.; Chakraborty, S.; Feller, F.; Khalaj, M.

10.1101/2022.02.07.479440 — cancer biology — Posted on 2022-02-08

2671 Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway

Abou Azar, F.; Mugabo, Y.; Yuen, S.; Del Veliz, S.; Lavoie, G.; Roux, P. P.; Lim, G. E.

10.1101/2022.02.03.478896 — biochemistry — Posted on 2022-02-08

2672 The influence of biological and statistical properties of CpGs on epigenetic predictions of eighteen traits

Hillary, R. F.; McCartney, D. L.; McRae, A. F.; Campbell, A.; Walker, R. M.; Hayward, C.; Horvath, S.; Porteous, D. J.; Evans, K. L.; Marioni, R. E.

10.1101/2022.02.08.479569 — genomics — Posted on 2022-02-08

2673 Host Variation in Type I Interferon Signaling Genes (MX1), CCR5{triangleup}32, and MHC Class I Alleles in Treated HIV+ Non-Controllers Predict Viral Reservoir Size

Siegel, D. A.; Thanh, C.; Wan, E.; Hoh, R.; Hobbs, K.; Pan, T.; Gibson, E. A.; Kroetz, D. L.; Hunt, P. W.; Martin, J.; Hecht, F.; Pilcher, C.; Milush, J.; Martin, M.; Carrington, M.; Pillai, S.; Busch, M. P.; Stone, M.; Huang, M.-L.; Roychoundhury, P.; Levy, C. N.; Jerome, K. R.; Kiem, H.-P.; Heinrich, T. J.; Deeks, S. G.; Lee, S.

10.1101/2021.10.31.466670 — genomics — Posted on 2022-02-08

2674 Impacts of climate change on California's rangeland production: sensitivity and future projection

Liu, H.; Jin, Y.; Roche, L. M.; O' Geen, A. T.; Dahlgren, R. A.

10.1101/2022.02.06.479265 — ecology — Posted on 2022-02-08

2675 Dynamic reorganization and selective segregation of mitochondria under DarT-mediated mtDNA damage

Dua, N.; Seshadri, A.; Badrinarayanan, A.

10.1101/2022.02.08.479562 — cell biology — Posted on 2022-02-08

2676 MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells

Saito, Y.; Santosa, V.; Ishiguro, K.-i.; Kanemaki, M. T.

10.1101/2022.02.08.479529 — molecular biology — Posted on 2022-02-08

2677 Proteomics profiling reveals regulation of immune response to Salmonella Typhimurium infection in mice

Huang, H.; Even, Z.; Erickson, A.; Li, L.; Golovko, M.; Golovko, S.; Mathur, R.; Wang, X.

10.1101/2022.02.08.479500 — immunology — Posted on 2022-02-08

2678 A flexible Bayesian framework for unbiased estimation of timescales

Zeraati, R.; Engel, T. A.; Levina, A.

10.1101/2020.08.11.245944 — neuroscience — Posted on 2022-02-08

2679 Hyperoxia improves repeated-sprint ability and the associated training load in athletes

Cyr-Kirk, S.; Billaut, F.

10.1101/2021.11.22.469617 — physiology — Posted on 2022-02-08

2680 Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy

Chambers, L.; Esakov, E. L.; Braley, C.; Trestan, L.; Alali, Z.; Bayik, D.; Lathia, J.; Sangwan, N.; Bazeley, P.; Joehlin-Price, A. S.; Dwidar, M.; Hajjar, A.; Ahern, P. P.; Claesen, J.; Rose, P.; Vargas, R.; Brown, J. M.; Michener, C.; Reizes, O.

10.1101/2020.06.16.155226 — cancer biology — Posted on 2022-02-08

2681 DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations

Nomidis, S. S.; Carlon, E.; Gruber, S.; Marko, J. F.

10.1101/2021.03.15.435506 — biophysics — Posted on 2022-02-08

2682 An efficient coalescent epoch model for Bayesian phylogenetic inference

Bouckaert, R.

10.1101/2021.06.28.450225 — bioinformatics — Posted on 2022-02-08

2683 SomaticSiMu: a mutational signature simulator

Chen, D.; Randhawa, G. S.; Soltysiak, M. P. M.; de Souza, C. P. E.; Kari, L.; Singh, S. M.; Hill, K.

10.1101/2021.09.30.462618 — bioinformatics — Posted on 2022-02-08

2684 Microbiome Maps: Hilbert Curve Visualizations of Metagenomic Profiles

Valdes, C.; Stebliankin, V.; Ruiz-Perez, D.; Park, J. I.; Lee, H.; Narasimhan, G.

10.1101/2021.03.22.436520 — bioinformatics — Posted on 2022-02-08

2685 Spatio-temporal, optogenetic control of gene expression in organoids

10.1101/2021.09.26.461850 — bioengineering — Posted on 2022-02-08

2686 Novel method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome

Keraite, I.; Becker, P.; Canevazzi, D.; Frias-Lopez, M. C.; Dabad, M.; Tonda-Hernandez, R.; Paramonov, I.; Ingham, M. J.; Brun-Heath, I.; Leno, J.; Abuli, A.; Garcia-Arumi, E.; Heath, S.; Gut, M.; Gut, I. G.

10.1101/2022.02.08.479581 — genomics — Posted on 2022-02-08

2687 Translation of upstream open reading frames does not trigger nonsense-mediated decay in Arabidopsis

Wu, H.-Y. L.; Hsu, P. Y.

10.1101/2021.09.16.460672 — genomics — Posted on 2022-02-08

2688 The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase

Knighton, L. E.; Nitika, ; Omkar, S.; Truman, A. W.

10.1101/2022.02.08.479504 — genetics — Posted on 2022-02-08

2689 The NOD/RIPK2 signaling pathway contributes to osteoarthritis susceptibility

Jurynec, M.; Gavile, C.; Honeggar, M.; Ma, Y.; Veerabhadraiah, S.; Novak, K.; Hoshijima, K.; Kazmers, N.; Grunwald, D.

10.1101/2022.02.07.479420 — genetics — Posted on 2022-02-08

2690 Finding mutations in all the wrong places: Prevalence of knock-down resistance F1534S 1 mutations among Aedes albopictus (family: Culicidae, order: Diptera) in North Carolina

Abernathy, H. A.; Hollingsworth, B. D.; Giandomenico, D. A.; Moser, K. A.; Juliano, J. J.; Bowman, N. M.; George, P. J.; Reiskind, M. H.; Boyce, R. M.

10.1101/2022.02.08.479572 — ecology — Posted on 2022-02-08

2691 Salp blooms increase carbon export 5-fold in the Southern Ocean

Decima, M.; Stukel, M. R.; Nodder, S.; Gutierrez, A.; Selph, K.; Lopes dos Santos, A.; Safi, K.; Kelly, T.; Deans, F.; Morales, S. E.; Baltar, F.; Latasa, M.; Maxim, G.; Pinkerton, M.

10.1101/2022.02.07.479467 — ecology — Posted on 2022-02-08

2692 unc-37/Groucho and lsy-22/AES repress Wnt target genes in C. elegans asymmetric cell divisions

Bekas, K. N.; Phillips, B. T.

10.1101/2022.01.10.475695 — developmental biology — Posted on 2022-02-08

2693 Anabolic Factors and Myokines Improve Differentiation of Human Embryonic Stem Cell Derived Skeletal Muscle Cells

Ruan, T.; Harney, D.; Koay, Y. C.; Loo, L.; Larance, M.; Caron, L.

10.1101/2022.02.08.477036 — cell biology — Posted on 2022-02-08

2694 N-phosphonacetyl-L-aspartate enhances type I interferon anti-viral responses through activation of non-canonical NOD2 signaling

Ponti, A. K.; Zangara, M. T.; O'Connor, C.; Johnson, E. E.; McDonald, C.

10.1101/2022.02.08.479597 — molecular biology — Posted on 2022-02-08

2695 Deep tissue infection by an invasive human fungal pathogen requires novel lipid-based suppression of the IL-17 response

Basso, P.; Dang, E. V.; Urisman, A.; Madhani, H. D.; Cowen, L. E.; Noble, S. M.

10.1101/2022.02.07.479457 — microbiology — Posted on 2022-02-08

2696 Infection strategy and biogeography distinguish cosmopolitan groups of marine jumbo bacteriophages

Weinheimer, A. R.; Aylward, F. O.

10.1101/2022.01.18.476781 — microbiology — Posted on 2022-02-08

2697 A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3'-terminus untranslated region

Lu, S.; Luo, S.; Liu, C.; Li, M.; An, X.; Li, M.; Hou, J.; Fan, H.; Mao, P.; Tong, Y.-G.; Song, L.

10.1101/2022.02.07.479352 — microbiology — Posted on 2022-02-08

2698 Genesis of bursting activity: Role of inhibitory constraints on persistent Na+ currents

Neveu, C. L.; Baxter, D. A.; Byrne, J. H.

10.1101/2022.02.05.479270 — neuroscience — Posted on 2022-02-08

2699 Auditory processing remains sensitive to environmental experience during adolescence

Anbuhl, K. L.; Yao, J. D.; Hotz, R. A.; Mowery, T. M.; Sanes, D. H.

10.1101/2021.04.12.439537 — neuroscience — Posted on 2022-02-08

2700 Daily caffeinated soda intake in children is associated with neurocognitive vulnerabilities of substance misuse and predicts higher risk of alcohol sipping in 12 months

Kwon, M.; Kim, H.; Yang, J.; Lee, Y.; Hur, J. K.; Lee, T.-H.; Ahn, W.-Y.

10.1101/2021.02.17.431718 — neuroscience — Posted on 2022-02-08

2701 Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells

Veling, M. T.; Nguyen, D. T.; Thadani, N. N.; Oster, M. E.; Rollins, N. J.; Brock, K. P.; Bethel, N. P.; Lim, S.; Baker, D.; Way, J. C.; Marks, D. S.; Chang, R. L.; Silver, P. A.

10.1101/2021.10.01.462432 — synthetic biology — Posted on 2022-02-08

2702 Multiple paths lead to salt tolerance - pre-adaptation vs dynamic responses from two closely related extremophytes

Tran, K.-N.; Wang, G.; Oh, D.-H.; Larkin, J. C.; Smith, A. P.; Dassanayake, M.

10.1101/2021.10.23.465591 — plant biology — Posted on 2022-02-08

2703 A concurrent canonical and modified miRNAome pan-cancer study on TCGA and TARGET cohorts leads to an enhanced resolution in cancer

Distefano, R.; Tomasello, L.; Vinciguerra, G. L. R.; Gasparini, P.; Xiang, Y.; Bagnoli, M.; Marceca, G. P.; Fadda, P.; Lagana, A.; Acunzo, M.; Ma, Q.; Nigita, G.; Croce, C. M.

10.1101/2021.05.18.444694 — cancer biology — Posted on 2022-02-08

2704 CRSP: Comparative RNA-seq pipeline for species lacking both of sequenced genomes and reference transcripts

Bagheri, A.; Dewey, C.; Stewart, R.; Jiang, P.

10.1101/2022.02.04.479193 — bioinformatics — Posted on 2022-02-08

2705 Belayer: Modeling discrete and continuous spatial variation in gene expression from spatially resolved transcriptomics

Ma, C.; Chitra, U.; Zhang, S.; Raphael, B. J.

10.1101/2022.02.05.479261 — bioinformatics — Posted on 2022-02-08

2706 Sketching and sampling approaches for fast and accurate long read classification

Das, A.; Schatz, M. C.

10.1101/2021.11.04.467374 — bioinformatics — Posted on 2022-02-08

2707 Identification of Unusual Oxysterols Biosynthesised in Human Pregnancy by Charge-Tagging and Liquid Chromatography - Mass Spectrometry

Dickson, A. L.; Yutuc, E.; Thornton, C. A.; Wang, Y.; Griffiths, W. J.

10.1101/2022.02.07.478301 — biochemistry — Posted on 2022-02-08

2708 High-performance GPCR optogenetics based on molecular properties of animal opsins, MosOpn3 and LamPP

Koyanagi, M.; Shen, B.; Nagata, T.; Sun, L.; Wada, S.; Kamimura, S.; Kage-Nakadai, E.; Terakita, A.

10.1101/2022.02.07.479375 — biochemistry — Posted on 2022-02-08

2709 A tissue specific atlas of gene promoter DNA methylation variability and the clinical value of its assessment

Miller, R. H.; Pollard, C. A.; Brogaard, K. R.; Olson, A. C.; Lipshultz, L. I.; Johnstone, E. B.; Ibrahim, Y. O.; Hotaling, J. M.; Schisterman, E. F.; Mumford, S. L.; Aston, K. I.; Jenkins, T. G.

10.1101/2022.02.04.479170 — genomics — Posted on 2022-02-08

2710 Analysis of Sexual vs Asexual Reproduction Using Four Measurements

Lin, F.; Lin, R.

10.1101/2022.02.05.479258 — evolutionary biology — Posted on 2022-02-08

2711 Expression and secretion of circular RNAs in the parasitic nematode, Ascaris suum

Minkler, S.; Loghry, H. J.; Sondjaja, N. A.; Kimber, M. J.

10.1101/2022.02.08.479594 — cell biology — Posted on 2022-02-08

2712 A transcription factor and a phosphatase regulate temperature-dependent morphogenesis in a fungal plant pathogen

Francisco, C. S.; McDonald, B. A.; Palma-Guerrero, J.

10.1101/2022.02.07.479299 — molecular biology — Posted on 2022-02-08

2713 Influenza A virus reassortment in mammals gives rise to genetically distinct within-host sub-populations

Ganti, K.; Bagga, A.; Ferreri, L. M.; Geiger, G.; Carnaccini, S.; Caceres, J.; Seibert, B. A.; Li, Y.; Wang, L.; Kwon, T.; Li, Y.; Morozov, I.; Ma, W.; Richt, J. A.; Perez, D. R.; Koelle, K.; Lowen, A. C.

10.1101/2022.02.08.479600 — microbiology — Posted on 2022-02-08

2714 Multi-excitation Raman Spectroscopy Complements Whole Genome Sequencing for Rapid Detection of Bacterial Infection and Resistance in WHO Priority Pathogens

Lister, A.; Avershina, E.; Ali, J.; Devitt, G.; Hanrahan, N.; Highmore, C. J.; Webb, J. S.; Müller, F.; Mahajan, S.; Ahmad, R.

10.1101/2022.02.08.479540 — microbiology — Posted on 2022-02-08

2715 IMPACT OF PHYLLOSPHERE METHYLOBACTERIUM ON HOST RICE LANDRACES

Sanjenbam, P.; Shivaprasad, P.; Agashe, D.

10.1101/2022.02.07.479485 — microbiology — Posted on 2022-02-08

2716 Changes in interactions over ecological time scales influence single cell growth dynamics in a metabolically coupled marine microbial community

Daniels, M.; van Vliet, S.; Ackermann, M.

10.1101/2022.02.08.479118 — microbiology — Posted on 2022-02-08

2717 Transcriptome Mining Reveals a Spectrum of RNA Viruses in Primitive Plants

Mifsud, J. C.; Gallagher, R. V.; Holmes, E. C.; Geoghegan, J. L.

10.1101/2022.02.07.479358 — microbiology — Posted on 2022-02-08

2718 The Brazilian population of Fusarium oxysporum f. sp. cubense is not structured by VCG or by geographic origin

Batista, I. C. A.; Heck, D. W.; Santos, A.; Alves, G.; Ferro, C. G.; Dita, M.; Michereff, S. J.; Correia, K. C.; Silva, C. F. B.; Mizubuti, E. S. G.

10.1101/2022.02.08.479520 — microbiology — Posted on 2022-02-08

2719 A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion system

Cheng, E.; Dorjsuren, D.; Lehman, S. S.; Larson, C. L.; Titus, S.; Sun, H.; Zakharov, A.; Rai, G.; Heinzen, R. A.; Simeonov, A.; Machner, M. P.

10.1101/2022.02.07.479497 — microbiology — Posted on 2022-02-08

2720 Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

Byerly, C.; Mitra, S.; Patterson, L. L.; Pittner, N. A.; Velayutham, T. S.; Paessler, S.; Veljkovic, V.; McBride, J. W.

10.1101/2022.02.08.479502 — microbiology — Posted on 2022-02-08

2721 Spike Protein-independent Attenuation of SARS-CoV-2 Omicron Variant in Laboratory Mice

Liu, S.; Selvaraj, P.; Sangare, K.; Luan, B.; Wang, T. T.

10.1101/2022.02.08.479543 — microbiology — Posted on 2022-02-08

2722 Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites

Sadic, M.; Schneider, W. M.; Katsara, O.; Medina, G. N.; Mogulothu, A.; Yu, Y.; Gu, M.; de los Santos, T.; Schneider, R. J.; Dittmann, M.

10.1101/2022.02.08.479557 — microbiology — Posted on 2022-02-08

2723 Light/dark and temperature cycling modulate metabolic electron flow in Pseudomonas aeruginosa biofilms

Kahl, L. J.; Eckartt, K.; Morales, D. K.; Price-Whelan, A.; Dietrich, L. E. P.

10.1101/2022.02.07.479496 — microbiology — Posted on 2022-02-08

2724 NMNAT2 in cortical glutamatergic neurons exerts both cell and non-cell autonomous influences to shape cortical development and to maintain neuronal health

Niou, Z.-X.; Yang, S.; Sri, A.; Rodriquez, H. C.; Gilley, J.; Coleman, M. P.; Lu, H.-C.

10.1101/2022.02.05.479195 — neuroscience — Posted on 2022-02-08

2725 Neural responses to broadband visual flicker in marmoset primary visual cortex

Schwenk, J. C. B.; Hagan, M. A.; Cloherty, S. L.; Zavitz, E.; Morris, A. P.; Price, N. S. C.; Rosa, M. G. P.; Bremmer, F.

10.1101/2022.02.05.479227 — neuroscience — Posted on 2022-02-08

2726 A longitudinal CA2/3 to CA1 circuit for initiating context-dependent associative learning

Chen, H.-S.; Qiu, S.; Wang, G.-L.; Yang, R.-R.; Zhang, N.; Wu, J.-N.; Yang, Q.-X.; Xu, C.

10.1101/2022.02.05.479215 — neuroscience — Posted on 2022-02-08

2727 Neuroaffective profiles are associated with e-cigarette use

Versace, F.; Kypriotakis, G.

10.1101/2022.02.04.479183 — neuroscience — Posted on 2022-02-08

2728 A chromosome-level phased Citrus sinensis genome facilitates understanding Huanglongbing tolerance mechanisms at the allelic level in an irradiation induced mutant

Wu, B.; Yu, Q.; Deng, Z.; Duan, Y.; Luo, F.; Gmitter, F.

10.1101/2022.02.05.479263 — plant biology — Posted on 2022-02-08

2729 Blocking Gi/o-coupled signaling eradicates cancer stem cells and sensitizes breast tumors to HER2-targeted therapies to inhibit tumor relapse

Lyu, C.; Ye, Y.; Weigel, R. J.; Chen, S.

10.1101/2022.02.05.479272 — cancer biology — Posted on 2022-02-08

2730 LRLoop: Feedback loops as a design principle of cell-cell communication

Xin, Y.; Lyu, P.; Jiang, J.; Zhou, F.; Wang, J.; Blackshaw, S.; Qian, J.

10.1101/2022.02.04.479174 — bioinformatics — Posted on 2022-02-08

2731 Neural decoding from surface high-density EMG signals: influence of anatomy and synchronization on the number of identified motor units

Souza de Oliveira, D.; Casolo, A.; Balshaw, T. G.; Maeo, S.; Bahia Lanza, M.; Martin, N. R. W.; Maffulli, N.; Kinfe, T. M.; Eskofier, B.; Folland, J. P.; Farina, D.; Del Vecchio, A.

10.1101/2022.02.05.479100 — bioengineering — Posted on 2022-02-08

2732 The genetics of specific cognitive abilities

Procopio, F.; Zhou, Q.; Wang, Z.; Gidziela, A.; Rimfeld, K.; Malanchini, M.; Plomin, R.

10.1101/2022.02.05.479237 — genetics — Posted on 2022-02-08

2733 An orderly sequence of autonomic and neural events at transient arousal changes

Gu, Y.; Han, F.; SAINBURG, L. E.; Schade, M. M.; Buxton, O. M.; Duyn, J. H.; Liu, X.

10.1101/2022.02.05.479238 — neuroscience — Posted on 2022-02-08

2734 Evaluation of the α-synuclein PET radiotracer (d3)-MODAG-001 in pigs

Raval, N. R.; Madsen, C. A.; Shalgunov, V.; Nasser, A.; Battisti, U. M.; Beaman, E. E.; Juhl, M.; Jorgensen, L. M.; Herth, M. M.; Hansen, H. D.; Plaven-Sigray, P.; Knudsen, G. M.

10.1101/2022.02.05.479231 — neuroscience — Posted on 2022-02-08

2735 A wearable platform for closed-loop stimulation and recording of single- neuron and local field potential activity in freely-moving humans

Topalovic, U.; Barclay, S.; Ling, C.; Alzuhair, A.; Yu, W.; Hokhikyan, V.; Chandrakumar, H.; Rozgic, D.; Jiang, W.; Basir-Kazeruni, S.; Maoz, S. L.; Inman, C. S.; Bari, A.; Fallah, A.; Eliashiv, D.; Fried, I.; Suthana, N.; Markovic, D.

10.1101/2022.02.05.479253 — neuroscience — Posted on 2022-02-08

2736 Selective influence of dopamine on electrocortical signatures of error monitoring: a combined EEG and immersive virtual reality study in Parkinson's disease

Pezzetta, R.; Ozkan, D. G.; Era, V.; Tieri, G.; Zabberoni, S.; Taglieri, S.; Costa, A.; Peppe, A.; Caltagirone, C.; Aglioti, S. M.

10.1101/2022.02.05.478638 — neuroscience — Posted on 2022-02-08

2737 Category-specific fMRI Correlates of Picture Naming: a study with Arabs and Filipinos

Tayeb, H. O.; Alghamdi, J.; Ahmed, N.; Alsawwaf, Y.; Alsafi, K.; Baduwailan, A.; Yaghmoor, B.; Elyas, T.; Mudarris, M.; Weisholtz, D. S.

10.1101/2022.02.05.478294 — neuroscience — Posted on 2022-02-08

2738 Accelerated cognitive decline in obese mouse model of Alzheimer's disease is linked to sialic acid-driven immune deregulation

Suzzi, S.; Croese, T.; Ravid, A.; Gold, O.; Clark, A. R.; Medina, S.; Kitsberg, D.; Adam, M.; Vernon, K. A.; Kohnert, E.; Shapira, I.; Malitsky, S.; Itkin, M.; Colaiuta, S. P.; Cahalon, L.; Slyper, M.; Greka, A.; Habib, N.; Schwartz, M.

10.1101/2022.02.05.479219 — neuroscience — Posted on 2022-02-08

2739 Expression analysis of Huntington disease mouse models reveals robust striatum disease signatures

Obenauer, J. C.; Chen, J.; Andreeva, V.; Aaronson, J. S.; Lee, R.; Caricasole, A.; Rosinski, J.

10.1101/2022.02.04.479180 — neuroscience — Posted on 2022-02-08

2740 Time-Optimal Adaptation in Metabolic Network Models

Koebis, M. A.; Bockmayr, A.; Steuer, R.

10.1101/2022.02.05.479110 — systems biology — Posted on 2022-02-08

2741 Disentangling the molecular mechanisms underlying the retrieval and extinction of morphine withdrawal-associated memories in the basolateral amygdala and dentate gyrus.

Franco-Garcia, A.; Fernandez-Gomez, F. J.; Gomez-Murcia, V.; Hidalgo, J. M.; Milanes, M. V.; Nunez, C.

10.1101/2022.02.05.479241 — pharmacology and toxicology — Posted on 2022-02-08

2742 TNF signaling is required for castration-induced vascular damage preceding prostate cancer regression

Krolewski, J. J.; Singh, S.; Sha, K.; Jaiswal, N.; Turowski, S. G.; Pan, C.; Rich, L. J.; Seshadri, M.; Nastiuk, K. L.

10.1101/2022.02.05.479251 — cancer biology — Posted on 2022-02-08

2743 AI-Generated Virtual Libraries Could Help Uncover RNA-Specific Regions of Chemical Space

Xu, Z.; Frank, A. T.

10.1101/2022.02.05.479230 — biophysics — Posted on 2022-02-08

2744 Single-Droplet Surface-Enhanced Raman Scattering Decodes the Molecular Language of Liquid-Liquid Phase Separation

Avni, A.; Joshi, A.; Walimbe, A.; Pattanashetty, S. G.; Mukhopadhyay, S.

10.1101/2022.02.05.479225 — biophysics — Posted on 2022-02-08

2745 SpatialCorr: Identifying Gene Sets with Spatially Varying Correlation Structure

Bernstein, M. N.; Ni, Z.; Prasad, A.; Brown, J.; Mohanty, C.; Stewart, R.; Newton, M. A.; Kendziorski, C.

10.1101/2022.02.04.479191 — bioinformatics — Posted on 2022-02-08

2746 The usefulness of sparse k-means in metabolomics data: Anexample from breast cancer data

Goudo, M.; Sugimoto, M.; Hiwa, S.; Hiroyasu, T.

10.1101/2022.02.05.479235 — bioinformatics — Posted on 2022-02-08

2747 Demography and linked selection interact to shape the genomic landscape of codistributed woodpeckers during the Ice Age

Rocha Moreira, L.; Klicka, J.; Smith, B. T.

10.1101/2022.02.04.479011 — evolutionary biology — Posted on 2022-02-08

2748 Summary statistics of memory-related fMRI activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging

Richter, A.; Soch, J.; Kizilirmak, J. M.; Fischer, L.; Schütze, H.; Assmann, A.; Behnisch, G.; Feldhoff, H.; Knopf, L.; Raschick, M.; Schult, A.; Seidenbecher, C. I.; Yakupov, R.; Düzel, E.; Schott, B. H.

10.1101/2022.02.04.479169 — neuroscience — Posted on 2022-02-08

2749 The Heart's Pacemaker Mimics Brain Cytoarchitecture and Function: Autonomic innervation, a peripheral glial cell web, and a novel S100B expressing interstitial cell type impart structural and functional complexity to the sinoatrial node

Bychkov, R.; Juhaszova, M.; Calvo-Rubio, M.; Donald, L. A.; Coletta, C.; Moorman, K. M.; Tagirova Sirenko, S.; Shumaker, C.; Maltsev, A. V.; Sollott, S. J.; Lakatta, E. G.

10.1101/2022.02.04.478900 — physiology — Posted on 2022-02-08

2750 Parallel evolution of amphioxus and vertebrate small-scale gene duplications

Braso-Vives, M.; Marletaz, F.; Echchiki, A.; Mantica, F.; Acemel, R. D.; Gomez-Skarmeta, J. L.; Targa, L. L.; Pontarotti, P.; Tena, J. J.; Maeso, I.; Escriva, H.; Irimia, M.; Robinson-Rechavi, M.

10.1101/2022.01.18.476203 — evolutionary biology — Posted on 2022-02-08

2751 Dual regulation of the actin cytoskeleton by CARMIL-GAP

Jung, G.; Pan, M.; Alexander, C.; Jin, T.; Hammer, J.

10.1101/2021.03.09.434482 — cell biology — Posted on 2022-02-08

2752 PELP: accounting for missing data in neural time series by Periodic Estimation of Lost Packets

Dastin-van Rijn, E.; Provenza, N. R.; Goodman, W.; Harrison, M.; Borton, D. A.

10.1101/2022.02.04.479162 — neuroscience — Posted on 2022-02-08

2753 Non-linearities and Timescales in Temporal Interference Deep Brain Stimulation

Plovie, T.; Schoeters, R.; Tarnaud, T.; Martens, L.; Joseph, W.; Tanghe, E.

10.1101/2022.02.04.479138 — neuroscience — Posted on 2022-02-08

2754 Absolute Winding Number Differentiates Spatial Navigation Strategies with Genetic Risk for Alzheimer's Disease

Badea, A.; Li, D.; Niculescu, A. R.; Anderson, R. J.; Stout, J. A.; Williams, C. L.; Colton, C. A.; Maeda, N.; Dunson, D. B.

10.1101/2022.02.04.479128 — neuroscience — Posted on 2022-02-08

2755 Real-time Image Denoising of Mixed Poisson-Gaussian Noise in Fluorescence Microscopy Images using ImageJ

Mannam, V.; Zhang, Y.; Zhu, Y.; Nichols, E.; Wang, Q.; Sundaresan, V.; Zhang, S.; Smith, C.; Bohn, P. W.; Howard, S.

10.1101/2021.11.10.468102 — neuroscience — Posted on 2022-02-08

2756 The multi-level phenotypic impact of synonymous substitutions: heterologous gene expression in human cells.

Picard, M. A. L.; Leblay, F.; Cassan, C.; Willemsen, A.; Daron, J.; Bauffe, F.; Decourcelle, M.; Demange, A.; Bravo, I. G.

10.1101/2022.01.07.475042 — systems biology — Posted on 2022-02-08

2757 Beta HPV8 E6 Induces Micronuclei Formation and Promotes Chromothripsis

Dacus, D.; Stancic, S.; Pollina, S. R.; Riforgiate, E.; Palinski, R.; Wallace, N. A.

10.1101/2022.02.03.479074 — cancer biology — Posted on 2022-02-08

2758 ColabFold - Making protein folding accessible to all

Mirdita, M.; Schuetze, K.; Moriwaki, Y.; Heo, L.; Ovchinnikov, S.; Steinegger, M.

10.1101/2021.08.15.456425 — bioinformatics — Posted on 2022-02-08

2759 scDeepHash: An automatic cell type annotation and cell retrieval method for large-scale scRNA-seq datasets using neural network-based hashing

Ma, S.; Zhang, Y.; Wang, B.; Hu, Z.; Zhang, J.; Wang, B.

10.1101/2021.11.08.467820 — bioinformatics — Posted on 2022-02-08

2760 Specific Peptides Predict Protein Classification.

Horn, D.; Weingart, U.

10.1101/2022.02.04.479085 — bioinformatics — Posted on 2022-02-08

2761 Cell Type Composition Analysis: Comparison of statistical methods

Simmons, S. K.

10.1101/2022.02.04.479123 — bioinformatics — Posted on 2022-02-08

2762 Brain strain rate response: addressing computational ambiguity and experimental data for model validation

Zhou, Z.; Li, X.; Liu, Y.; Hardy, W.; Kleiven, S.

10.1101/2022.02.04.478773 — bioengineering — Posted on 2022-02-08

2763 Motivational trade-offs in bumblebees

Gibbons, M.; Versace, E.; Crump, A.; Baran, B.; Chittka, L.

10.1101/2022.02.04.479111 — animal behavior and cognition — Posted on 2022-02-08

2764 Marine gregarine genomes reveal the breadth of apicomplexan diversity and provide new insights on gliding motility

Boisard, J.; Duvernois-Berthet, E.; Duval, L.; Schrevel, J.; Guillou, L.; Labat, A.; Le Panse, S.; Prensier, G.; Ponger, L.; Florent, I.

10.1101/2021.08.09.454911 — genomics — Posted on 2022-02-08

2765 Tracing genetic connections of ancient Hungarians to the 6-14th century populations of the Volga-Ural region

Szeifert, B.; Gerber, D.; Csaky, V.; Lango, P.; Stashenkov, D. A.; Khokhlov, A. A.; Sitdikov, A. G.; Gazimzyanov, I. R.; Volkova, E. V.; Matveeva, N. P.; Zelenkov, A. S.; Poshekhonova, O. E.; Sleptsova, A. V.; Karacharov, K. G.; Ilyushina, V. V.; Konikov, B. A.; Sungatov, F. A.; Kolonskikh, A. G.; Botalov, S. G.; Grudochko, I. V.; Egyed, B.; Mende, B. G.; Turk, A.; Szecsenyi-Nagy, A.

10.1101/2022.02.04.478947 — genetics — Posted on 2022-02-08

2766 Genomic bases of insularity and ecological divergence in barn owls (Tyto alba) of the Canary Islands

Cumer, T.; Machado, A. P.; Siverio, F.; Cherkaoui, S. I.; Roque, I.; Lourenco, R.; Charter, M.; Roulin, A.; Goudet, J.

10.1101/2021.12.24.473866 — evolutionary biology — Posted on 2022-02-08

2767 Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

Tu, J.; Kumar, A.; Giorgi, E.; Eudailey, J. A.; LaBranche, C.; Martinez, D.; Fouda, G. G.; Moreau, Y.; Thomas, A.; Montefiori, D.; Gao, F.; Sagar, M.; Permar, S. R.

10.1101/2022.02.03.479075 — immunology — Posted on 2022-02-08

2768 Fingerprinting of brain disease: Connectome identifiability in cognitive decline and neurodegeneration

Stampacchia, S.; Asadi, S.; Tomczyk, S.; Ribaldi, F.; Scheffler, M.; Lovblad, K.-O.; Pievani, M.; Frisoni, G. B.; Garibotto, V.; Amico, E.

10.1101/2022.02.04.479112 — neuroscience — Posted on 2022-02-08

2769 Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Hillege, M.; Shi, A.; Galli, R. A.; Wu, G.; Bertolino, P.; Hoogaars, W. M.; Jaspers, R. T.

10.1101/2021.03.03.433740 — physiology — Posted on 2022-02-08

2770 Discovery and synthesis of hydroxy-L-proline based blockers of the neutral amino acid transporters SLC1A4 (ASCT1) and SLC1A5 (ASCT2).

Kavanaugh, M. P.; Lyda, B. R.; Leary, G. P.; Silvius, D.; Natale, N. R.; Esslinger, C. S.; Seaver, B.; Farnsworth, J.

10.1101/2021.12.14.470456 — pharmacology and toxicology — Posted on 2022-02-08

2771 Can DyeCycling break the photobleaching limit in single-molecule FRET?

Vermeer, B.; Schmid, S.

10.1101/2022.02.08.479542 — biophysics — Posted on 2022-02-08

2772 Membrane insertion mechanism of the caveolae coat protein Cavin1

Liu, K.-c.; Pace, H.; Larsson, E.; Hossain, S.; Kabedev, A.; Shukla, A.; Jerschabek, V.; Mohan, J.; Bergstrom, C. A. S.; Bally, M.; Schwieger, C.; Hubert, M.; Lundmark, R.

10.1101/2021.03.23.436578 — biochemistry — Posted on 2022-02-08

2773 Entrainment to sleep spindles reflects dissociable patterns of connectivity between cortex and basal ganglia

Mizrahi-Kliger, A. D.; Kaplan, A.; Israel, Z.; Bergman, H.

10.1101/2022.02.06.479277 — neuroscience — Posted on 2022-02-08

2774 Non-synaptic alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior

Malgady, J. M.; Baez, A.; Jimenez, K.; Hobel, Z. B.; Prager, E. M.; Zhang, Q.; Feng, G.; Plotkin, J. L.

10.1101/2022.02.07.479446 — neuroscience — Posted on 2022-02-08

2775 Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

Watson, E. T.; Pauers, M. M.; Vevea, J. D.; Chapman, E. R.

10.1101/2022.02.08.479521 — neuroscience — Posted on 2022-02-08

2776 Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65)

Tan, R. P. A.; Kozlova, I.; Su, F.; Sah, S.; Keable, R.; Hagan, D. W.; Bustamante, S.; Du, X.; Osborne, B.; Turner, N.; Clemens, K.; Begg, D.; Phelps, E. A.; Yang, H.; Leshchyns'ka, I.; Sytnyk, V.

10.1101/2022.02.08.479601 — neuroscience — Posted on 2022-02-08

2777 ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms.

Mineur, Y.; Mose, T. N.; Lefoli Maibom, K.; Pittenger, S.; Soares, A. R.; Wu, H.; Huang, Y.; Picciotto, M.

10.1101/2022.02.08.479551 — neuroscience — Posted on 2022-02-08

2778 High Fat Diet Blunts Stress-Induced Hypophagia and Activation of Glp1r Dorsal Lateral Septum Neurons in Male but not in Female Mice

Bales, M. B.; Centanni, S. W.; Luchsinger, J. R.; Nwaba, K. G.; Paldrmic, I. M.; Winder, D. G.; Ayala, J. E.

10.1101/2022.02.08.479553 — neuroscience — Posted on 2022-02-08

2779 Scale-Dependent Coherence of Terrestrial Vertebrate Biodiversity with Environment

O'Malley, C. P. B.; Roberts, G. G.; Mannion, P. D.; Hackel, J.; Wang, Y.

10.1101/2022.01.21.477239 — systems biology — Posted on 2022-02-08

2780 PBRM1 BD2 and BD4 associate with RNA to facilitate chromatin association

De Silva, S. M.; Sood, S.; Dhiman, A.; Mercedes, K. F.; Henen, M. A.; Vogeli, B.; Dykhuizen, E.; Musselman, C. A.

10.1101/2022.02.07.479474 — biochemistry — Posted on 2022-02-08

2781 Comparative assessment of quantification methods for tumor tissue phosphoproteomics

Zhang, Y.; Dreyer, B.; Govorukhina, N.; Heberle, A. M.; Koncarevic, S.; Krisp, C.; Opitz, C. A.; Pfander, P.; Bischoff, R.; Schluter, H.; Kwiatkowski, M.; Thedieck, K.; Horvatovich, P.

10.1101/2022.02.07.479414 — biochemistry — Posted on 2022-02-08

2782 Pre-B cell receptor acts as a selectivity switch for Galectin-1 at the pre-B cell surface

Touarin, P.; Serrano, B.; Courbois, A.; Bornet, O.; Chen, Q.; Scott, L. G.; Mancini, S. J. C.; Williamson, J. R.; Sebban-Kreuzer, C.; Elantak, L.

10.1101/2022.02.08.479506 — biochemistry — Posted on 2022-02-08

2783 The impact of housing conditions on mesenchymal stromal/stem cell populations differ between adipose tissue and skeletal muscle

QUEMENER, A.; DESSAUGE, F.; PERRUCHOT, M.-H.; LE FLOC'H, N.; LOUVEAU, I.

10.1101/2021.06.08.447546 — cell biology — Posted on 2022-02-08

2784 G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration

Moore, J. L.; Gao, F.; Matte-Martone, C.; Du, S.; Lathrop, E.; Ganesan, S.; Shao, L.; Bhaskar, D.; Cox, A.; Hendry, C. E.; Rieck, B. A.; Krishnaswamy, S.; Greco, V.

10.1101/2021.10.12.464066 — cell biology — Posted on 2022-02-08

2785 Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks

Mohan, H.; An, X.; Kondo, H.; Zhao, S.; Matho, K. S.; Musall, S.; Mitra, P. P.; Huang, Z. J.

10.1101/2021.12.30.474537 — neuroscience — Posted on 2022-02-08

2786 Recombination patterns in coronaviruses

Müller, N. F.; Kistler, K.; Bedford, T.

10.1101/2021.04.28.441806 — evolutionary biology — Posted on 2022-02-08

2787 EMoMiS: A Pipeline for Epitope-based Molecular Mimicry Search in Protein Structures with Applications to SARS-CoV-2

Stebliankin, V.; Baral, P.; Balbin, C.; Nunez-Castilla, J.; Sobhan, M.; Cickovski, T.; Mondal, A. M.; Siltberg-Liberles, J.; Chapagain, P.; Mathee, K.; Narasimhan, G.

10.1101/2022.02.05.479274 — bioinformatics — Posted on 2022-02-08

2788 The Motor Wisdom of the Crowd

Madirolas, G.; Zaghi-Lara, R.; Matic, A.; Gomez-Marin, A.; Perez-Escudero, A.

10.1101/2022.02.04.479103 — animal behavior and cognition — Posted on 2022-02-08

2789 Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

He, W.-t.; Musharrafieh, R.; Song, G.; Dueker, K.; Tse, L. V.; Martinez, D. R.; Schafer, A.; Callaghan, S.; Yong, P.; Beutler, N.; Torres, J. L.; Volk, R. M.; Zhou, P.; Yuan, M.; Liu, H.; Anzanello, F.; Capozzola, T.; Parren, M.; Garcia, E.; Rawlings, S. A.; Smith, D. M.; Wilson, I. A.; Safonova, Y.; Ward, A. B.; Rogers, T.; Baric, R. S.; Gralinski, L. E.; Burton, D. R.; Andrabi, R.

10.1101/2021.09.08.459480 — immunology — Posted on 2022-02-08

2790 Modulation in Alpha Band Activity Reflects Syntax Composition: An MEG Study of Minimal Syntactic Binding

Hardy, S. M.; Jensen, O.; Wheeldon, L.; Mazaheri, A.; Segaert, K.

10.1101/2021.07.09.451797 — neuroscience — Posted on 2022-02-08

2791 Enrichment of specific GABAergic neuronal types in the mouse perirhinal cortex

Nigro, M. J.; Kjelsberg, K.; Convertino, L.; NAIR, R. R.; Witter, M.

10.1101/2022.01.30.478360 — neuroscience — Posted on 2022-02-08

2792 Activation of LH GABAergic inputs counteracts fasting-induced changes in tVTA/RMTG neurons.

Godfrey, N.; Qiao, M.; Borgland, S. L.

10.1101/2021.11.24.469955 — neuroscience — Posted on 2022-02-08

2793 White matter microstructural and morphometric alterations in autism: Implications for intellectual capabilities

Yeh, C.-H.; Tseng, R.-Y.; Ni, H.-C.; Cocchi, L.; Chang, J.-C.; Hsu, M.-Y.; Tu, E.-N.; Wu, Y.-Y.; Chou, T.-L.; Gau, S. S.-F.; Lin, H.-Y.

10.1101/2021.10.11.464005 — neuroscience — Posted on 2022-02-08

2794 Algorithmic Reconstruction of GBM Network Complexity

Uthamacumaran, A.; Craig, M.

10.1101/2021.09.21.461255 — systems biology — Posted on 2022-02-08

2795 Biocompatible fluorocarbon liquid underlays for in situ extraction of isoprenoids from microbial cultures

Overmans, S.; Lauersen, K. J.

10.1101/2022.01.27.477974 — synthetic biology — Posted on 2022-02-08

2796 ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II.

Braun, T. P.; Estabrook, J.; Darmusey, L.; Coleman, D. J.; Schonrock, Z.; Smith, B. M.; Enright, T.; Taherinasab, A.; Coblentz, C.; Callahan, R.; Mohammed, H.; Druker, B. J.; Lusardi, T.; Maxson, J. E.

10.1101/2020.09.14.295295 — cancer biology — Posted on 2022-02-08

2797 Evaluation of in vitro and in vivo toxicity of pristine molybdenum disulphide nanosheets in Swiss albino mice

Saxena, P. S.; Yadav, U.; Mishra, H.; Singh, V.; Srivastava, A.

10.1101/2021.05.07.443109 — bioengineering — Posted on 2022-02-08

2798 Effects of climate warming on the pine processionary moth at the southern edge of its range: a retrospective analysis on egg survival in Tunisia

Bourougaaoui, A.; Robinet, C.; Ben Jamaa, M. L.; Laparie, M.

10.1101/2021.08.17.456665 — ecology — Posted on 2022-02-08

2799 AGO1 regulates pericentromeric regions in mouse embryonic stem cells

Mueller, M.; Faeh, T.; Schaefer, M.; Hermes, V.; Luitz, J.; Stalder, P.; Arora, R.; Ngondo, R. P.; Ciaudo, C.

10.1101/2021.07.26.453733 — cell biology — Posted on 2022-02-08

2800 MagnaExtract, a novel magnetic bead-based extraction method for the molecular detection of antimicrobial resistance genes in fresh water.

Byrne, R. L.; Cocker, D.; Alyayyoussi, G.; Mphasa, M.; Charles, M.; Mandula, T.; Williams, C. T.; Rigby, J.; Hearn, J.; Feasey, N.; Adams, E. R.; Edwards, T.

10.1101/2021.04.23.439981 — molecular biology — Posted on 2022-02-08

2801 Resting-state fMRI-based screening of deschloroclozapine in rhesus macaques predicts dosage-dependent behavioral effects

Fujimoto, A.; Elorette, C.; Fredericks, J. M.; Fujimoto, S. H.; Fleysher, L.; Rudebeck, P. H.; Russ, B. E.

10.1101/2021.11.24.469738 — neuroscience — Posted on 2022-02-08

2802 BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons.

Moya-Alvarado, G.; Guerra, M. V.; Wu, C.; Mobley, W. C.; Perlson, E.; Bronfman, F. C.

10.1101/2020.08.22.262923 — neuroscience — Posted on 2022-02-08

2803 Highly accurate retinotopic maps of the physiological blind spot in human visual cortex

Urale, P. W. B.; Puckett, A. M.; York, A.; Arnold, D.; Schwarzkopf, D. S.

10.1101/2021.11.29.470502 — neuroscience — Posted on 2022-02-08

2804 Excitatory and inhibitory motor cortical clusters account for balance, variability, and task performance

Rostami, V.; Rost, T.; Riehle, A.; van Albada, S. J.; P. Nawrot, M.

10.1101/2020.02.27.968339 — neuroscience — Posted on 2022-02-08

2805 Atypical and distinct microtubule radial symmetries in the centriole and the axoneme of Lecudina tuzetae.

Gönczy, P.; Bezler, A.; Woglar, A.; Schneider, F. Z.; Douma, F.; Bürgy, L. A.; Busso, C.

10.1101/2022.02.07.479401 — cell biology — Posted on 2022-02-08

2806 Assessing human genome-wide variation in the Massim region of Papua New Guinea and implications for the Kula trading tradition

Liu, D.; Peter, B. M.; Schiefenhoevel, W.; Kayser, M.; Stoneking, M.

10.1101/2022.02.06.479284 — genomics — Posted on 2022-02-08

2807 Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence

McArthur, E.; Rinker, D. C.; Gilbertson, E. N.; Fudenberg, G.; Pittman, M.; Keough, K.; Pollard, K. S.; Capra, J. A.

10.1101/2022.02.07.479462 — evolutionary biology — Posted on 2022-02-08

2808 Let's face it: The lateralization of the face perception network as measured with fMRI is not clearly right dominant

Thome, I.; Garcia Alanis, J. C.; Volk, J.; Vogelbacher, C.; Steinsträter, O.; Jansen, A.

10.1101/2022.02.06.479156 — neuroscience — Posted on 2022-02-08

2809 Control of neocortical memory by long-range inhibition in layer 1

Schroeder, A.; Pardi, M. B.; Keijser, J.; Dalmay, T.; Schuman, E.; Sprekeler, H.; Letzkus, J.

10.1101/2022.02.07.479360 — neuroscience — Posted on 2022-02-08

2810 High-throughput widefield fluorescence imaging of 3D samples using deep learning for 2D projection image restoration

Forsgren, E.; Edlund, C.; Oliver, M.; Barnes, K.; Sjögren, R.; Jackson, T. R.

10.1101/2022.02.07.479465 — cell biology — Posted on 2022-02-07

2811 OCTA observation of changes in macular vessel density in diabetic patients and its correlation with diabetic retinopathy staging

Deng, Y.; JIE, C.; Wang, J.; Liu, Z.; Li, Y.

10.1101/2022.02.07.479361 — neuroscience — Posted on 2022-02-07

2812 EMoMiS: A Pipeline for Epitope-based Molecular Mimicry Search in Protein Structures with Applications to SARS-CoV-2

Stebliankin, V.; Baral, P.; Balbin, C.; Nunez-Castilla, J.; Sobhan, M.; Cickovski, T.; Mondal, A. M.; Siltberg-Liberles, J.; Chapagain, P.; Mathee, K.; Narasimhan, G.

10.1101/2022.02.05.479274 — bioinformatics — Posted on 2022-02-07

2813 Comprehensive Epitope Mapping of Broad Sarbecovirus Neutralizing Antibodies

Cao, Y.; Yisimayi, A.; Jian, F.; Xiao, T.; Song, W.; Wang, J.; Du, S.; Zhang, Z.; Liu, P.; Hao, X.; Li, Q.; Wang, P.; An, R.; Wang, Y.; Wang, J.; Sun, H.; Zhao, L.; Zhang, W.; Zhao, D.; Zheng, J.; Yu, L.; Li, C.; Zhang, N.; Wang, R.; Niu, X.; Yang, S.; Song, X.; Zheng, L.; Li, Z.; Gu, Q.; Shao, F.; Huang, W.; Wang, Y.; Jin, R.; Xiao, J.; Xie, X. S.

10.1101/2022.02.07.479349 — immunology — Posted on 2022-02-07

2814 Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, A Potential Oral Drug Candidate for COVID-19 Treatment

Wang, A. Q.; Hagen, N. R.; Padilha, E. C.; Yang, M.; Shah, P.; Chen, C. Z.; Huang, W.; Terse, P.; Sanderson, P.; Zheng, W.; Xu, X.

10.1101/2022.02.07.478848 — pharmacology and toxicology — Posted on 2022-02-07

2815 Machine learning-based approach KEVOLVE efficiently identifies SARS-CoV-2 variant-specific genomic signatures

Lebatteux, D.; Diallo, A.; Gantt, S.; Boucoiran, I.; Soudeyns, H.

10.1101/2022.02.07.479343 — bioinformatics — Posted on 2022-02-07

2816 Predicting Schrödinger's range-shifting cat: Analytic results for the impact of asymmetric environmental dependence on species responses to climate change

Terry, C.; Dinner O'Sullivan, J. L.; Rossberg, A.

10.1101/2022.02.04.479140 — ecology — Posted on 2022-02-07

2817 Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

Chandrashekar, A.; Yu, J.; McMahan, K.; Jacob-Dolan, C.; Liu, J.; He, X.; Hope, D.; Anioke, T.; Barrett, J.; Chung, B.; Hachmann, N.; Lifton, M.; Miller, J.; Powers, O.; Sciacca, M.; Sellers, D.; Siamatu, M.; Surve, N.; VanWyk, H.; Wan, H.; Wu, C.; Pessaint, L.; Valentin, D.; Van Ry, A.; Muench, J.; Boursiquot, M.; Cook, A.; Velasco, J.; Teow, E.; Boon, A.; Suthar, M.; Jain, N.; Martinot, A. J.; Lewis, M. G.; Andersen, H.; Barouch, D. H.

10.1101/2022.02.06.479285 — microbiology — Posted on 2022-02-07

2818 A potent SARS-CoV-2 neutralizing antibody recognizing a conserved epitope with broad mutant variant and SARS-CoV activity.

Pelzek, A. J.; Ebtehaj, S.; Lulo, J.; Zhang, L.; Balduf, O.; Dolan, L.; Zhang, C.; Wan, S.; An, G.; Kankam, A.; Chan, E.; Murphy, S. P.

10.1101/2022.02.06.479332 — microbiology — Posted on 2022-02-07

2819 An mRNA vaccine candidate for the SARS-CoV-2 Omicron variant

Zang, J.; Zhang, C.; Yin, Y.; Xu, S.; Qiao, W.; LAVILLETTE, D.; Wang, H.; Huang, Z.

10.1101/2022.02.07.479348 — microbiology — Posted on 2022-02-07

2820 Mechanistic origin of different binding affinities of SARS-CoV and SARS-CoV-2 spike RBDs to human ACE2

Zhang, Z.-B.; Xia, Y.-L.; Shen, J.-X.; Du, W.-W.; Fu, Y.-X.; Liu, S.-Q.

10.1101/2022.02.05.479221 — biophysics — Posted on 2022-02-07

2821 Biologically informed deep learning to infer gene program activity in single cells

Lotfollahi, M.; Rybakov, S.; Hrovatin, K.; Hediyeh-zadeh, S.; Talavera-Lopez, C.; Misharin, A.; Theis, F. J.

10.1101/2022.02.05.479217 — bioinformatics — Posted on 2022-02-07

2822 Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross

Scoggin, K.; Lynch, R.; Gupta, J.; Nagarajan, A.; Sheffield, M.; Elsaadi, A.; Bowden, C.; Aminian, M.; Peterson, A.; Adams, L. G.; Kirby, M.; Threadgill, D.; Andrews-Polymenis, H. L.

10.1101/2022.02.07.479341 — genetics — Posted on 2022-02-07

2823 The diverse effects of phenotypic dominance on hybrid fitness

Schneemann, H.; Munzur, A. D.; Thompson, K. A.; Welch, J. J.

10.1101/2021.06.30.450598 — evolutionary biology — Posted on 2022-02-07

2824 Production of recombinant human acid α-glucosidase with mannosidic N-glycans in α-mannosidase I mutant rice cell suspension culture

Jung, J.-W.

10.1101/2022.02.07.479152 — molecular biology — Posted on 2022-02-07

2825 Discovery of integrons in Archaea: platforms for cross-domain gene transfer

Ghaly, T. M.; Tetu, S. G.; Penesyan, A.; Qi, Q.; Rajabal, V.; Gillings, M. R.

10.1101/2022.02.06.479319 — microbiology — Posted on 2022-02-07

2826 NGS data reveals the phyllosphere microbiome of wheat plants infected by the fungal pathogen Zymoseptoria tritici

Barroso-Bergada, D.; Massot, M.; Vignolles, N.; Favre d'Arcier, J.; Chancerel, E.; Guichoux, E.; Walker, A.-S.; Vacher, C.; Bohan, D. A.; Laval, V.; Suffert, F.

10.1101/2022.02.07.479402 — microbiology — Posted on 2022-02-07

2827 SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

Lieber, C. M.; Cox, R.; Sourimant, J.; Wolf, J. D.; Juergens, K.; Phung, Q.; Saindane, M. T.; Natchus, M. G.; Painter, G. R.; Sakamoto, K.; Greninger, A. L.; Plemper, R. K.

10.1101/2022.02.04.479171 — microbiology — Posted on 2022-02-07

2828 The role of the gut microbiota in patients with Kleefstra syndrome

Bloemendaal, M.; Vlaming, P.; de Boer, A.; Vermeulen-Kalk, K.; Bouman, A.; Kleefstra, T.; Arias Vasquez, A.

10.1101/2022.02.04.478662 — microbiology — Posted on 2022-02-07

2829 HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages

Han, M.; Cantaloube-Ferrieu, V.; Xie, M.; Armani-Tourret, M.; Woottum, M.; Pages, J.-C.; Colin, P.; Lagane, B.; Benichou, S.

10.1101/2022.02.07.479340 — microbiology — Posted on 2022-02-07

2830 Probabilistic Modeling Confirms Delayed, But Non-Deficient Locomotor Development in Low Birth Weight Piglets

Mielke, F.; Van Ginneken, C.; Aerts, P.

10.1101/2022.02.04.479126 — zoology — Posted on 2022-02-07

2831 Lipid network and moiety analyses reveal enzymatic dysregulation and altered mechanisms from lipidomics

Rose, T. D.; Koehler, N.; Falk, L.; Klischat, L.; Lazareva, O. E.; Pauling, J. K.

10.1101/2022.02.04.479101 — systems biology — Posted on 2022-02-07

2832 Glycan shield of the ebolavirus envelope glycoprotein GP

Peng, W.; Rayaprolu, V.; Parvate, A. D.; Pronker, M. F.; Hui, S.; Parekh, D.; Shaffer, K.; Yu, X.; Saphire, E. O.; Snijder, J.

10.1101/2022.02.07.479410 — biochemistry — Posted on 2022-02-07

2833 DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

Mondal, S.; Kinatukara, P.; Singh, S.; Shambhavi, S.; Patil, G. S.; Dubey, N.; Singh, S. H.; Pal, B.; Shekar, P. C.; Kamat, S. S.; Sankaranarayanan, R.

10.1101/2022.02.07.479356 — biochemistry — Posted on 2022-02-07

2834 Olfactory detection and discrimination in domestic dogs (Canis lupus familiaris)

Ferrando, E.; Dahl, C. D.

10.1101/2022.02.04.479113 — animal behavior and cognition — Posted on 2022-02-07

2835 Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice

Kuffler, L.; Skelly, D. A.; Czechanski, A.; Munger, S. C.; Baker, C. L.; Reinholdt, L. G.; Carter, G. W.

10.1101/2022.02.07.479436 — genetics — Posted on 2022-02-07

2836 Embracing imperfection: machine-assisted invertebrate classification in difficult datasets

Blair, J. D.; Weiser, M. D.; deBeurs, K.; Kaspari, M.; Siler, C. D.; Marshall, K. E.

10.1101/2021.09.13.460161 — ecology — Posted on 2022-02-07

2837 Predictability and transferability of local biodiversity environment relationships

Jung, M.

10.1101/2022.02.04.479149 — ecology — Posted on 2022-02-07

2838 Sugar alcohols have the potential as bee-safe feeding stimulants for wasp control

Neupert, S.; Jandt, J. M.; Szyszka, P.

10.1101/2022.02.04.479032 — ecology — Posted on 2022-02-07

2839 Spatio-temporal monitoring of lake fish spawning activity using environmental DNA metabarcoding

Di Muri, C.; Lawson Handley, L. J.; Bean, C. W.; Benucci, M.; Harper, L. R.; James, B.; Li, J.; Winfield, I. J.; Haenfling, B.

10.1101/2022.02.07.478003 — molecular biology — Posted on 2022-02-07

2840 Development of a Ribosome Profiling Protocol to Study Translation in the yeast Kluyveromyces marxianus

Fenton, D. A.; Kiniry, S. J.; Yordanova, M. M.; Baranov, P. V.; Morrissey, J. P.

10.1101/2022.02.06.478964 — molecular biology — Posted on 2022-02-07

2841 Designing a novel monitoring approach for the effects of space travel on astronauts' health

Sakharkar, A.; Yang, J.

10.1101/2022.02.06.479323 — molecular biology — Posted on 2022-02-07

2842 Detection of SARS-CoV-2 Omicron variant (B.1.1.529) infection of white-tailed deer

Vandegrift, K. J.; Yon, M.; Surendran-Nair, M.; Gontu, A.; Amirthalingam, S.; Nissly, R. H.; Levine, N.; Stuber, T.; DeNicola, A. J.; Boulanger, J. R.; Kotschwar, N.; Aucoin, S. G.; Simon, R.; Toal, K.; Olsen, R. J.; Davis, J. J.; Bold, D.; Gaudreault, N. N.; Richt, J. A.; Musser, J. M.; Hudson, P. J.; Kapur, V.; Kuchipudi, S. V.

10.1101/2022.02.04.479189 — microbiology — Posted on 2022-02-07

2843 Identification of functional Spo0A residues critical for sporulation in Clostridioides difficile

DiCandia, M. A.; Edwards, A. N.; Jones, J. B.; Swaim, G. L.; Mills, B. D.; McBride, S. M.

10.1101/2022.02.07.479450 — microbiology — Posted on 2022-02-07

2844 Genome-wide identification of fitness determinants in the Xanthomonas campestris bacterial pathogen during early stages of plant infection

Luneau, J. S.; Baudin, M.; Quiroz-Monnens, T.; Carrere, S.; Bouchez, O.; Jardinaud, M.-F.; Gris, C.; Francois, J.; Ray, J.; Torralba, B.; Arlat, M.; Lewis, J. D.; Deutschbauer, A. M.; Lauber, E.; Noël, L. D.; Boulanger, A.

10.1101/2022.02.07.479439 — microbiology — Posted on 2022-02-07

2845 Modified E2 glycoprotein of hepatitis C virus enhances pro-inflammatory cytokines and protective immune response in mice

Vijayamahantesh, V.; Patra, T.; Meyer, K.; Mohamad-Gabriel, A.; Reagan, E.; Weissman, D.; Ray, R.

10.1101/2022.02.07.479452 — microbiology — Posted on 2022-02-07

2846 Statistical learning and uncommon soil microbiota explain biogeochemical responses after wildfire

Honeyman, A. S.; Fegel, T. S.; Peel, H. F.; Masters, N. A.; Vuono, D. C.; Kleiber, W.; Rhoades, C. C.; Spear, J. R.

10.1101/2022.02.06.479310 — microbiology — Posted on 2022-02-07

2847 Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae

David, S.; Wong, J.; Sanchez-Garrido, J.; Kwong, J.; Low, W. W.; Morecchiato, F.; Giani, T.; Rossolini, G. M.; Brett, S.; Clements, A.; Beis, K.; Aanensen, D.; Frankel, G.

10.1101/2022.02.07.479342 — microbiology — Posted on 2022-02-07

2848 Ruminococcus bromii enables the growth of proximal Bacteroides thetaiotaomicron by releasing glucose during starch degradation

Anandhi Rangarajan, A.; Chia, H.; Azaldegui, C.; Olszewski, M.; Koropatkin, N.; Biteen, J. S.

10.1101/2022.02.07.479236 — microbiology — Posted on 2022-02-07

2849 Inflammatory monocytes promote pyogranuloma formation to counteract Yersinia blockade of host defense

Sorobetea, D.; Matsuda, R.; Peterson, S. T.; Grayczyk, J. P.; Rao, I.; Krespan, E.; Lanza, M.; Assenmacher, C.-A.; Beiting, D. P.; Radaelli, E.; Brodsky, I. E.

10.1101/2022.02.06.479204 — microbiology — Posted on 2022-02-07

2850 Enterovirus replication and dissemination are differentially controlled by type I and III interferons in the GI tract

Wells, A. I.; Grimes, K.; Coyne, C. B.

10.1101/2022.02.07.479406 — microbiology — Posted on 2022-02-07

2851 Feedback regulation of RNase E during UV-stress response in the cyanobacterium Synechocystis sp. PCC 6803

Watanabe, S.; Stazic, D.; Georg, J.; Ohtake, S.; Numakura, M.; Asayama, M.; Chibazakura, T.; Wilde, A.; Steglich, C.; Hess, W. R.

10.1101/2022.02.07.478427 — microbiology — Posted on 2022-02-07

2852 Phage therapy potentiates second-line antibiotic treatment against pneumonic plague

Vagima, Y.; Gur, D.; Aftalion, M.; Moses, S.; Levy, Y.; Makovitzki, A.; Holtzman, T.; Oren, Z.; Segula, Y.; Fatelevich, E.; Tidhar, A.; Zauberman, A.; Rotem, S.; Mamroud, E.; Steinberger-Levy, I.

10.1101/2022.02.07.479346 — microbiology — Posted on 2022-02-07

2853 Theta band-power shapes amyloid-driven longitudinal EEG changes in pre-clinical Alzheimer's Disease

Spinelli, G.; Bakardjian, H.; Schwartz, D.; Potier, M.-C.; Habert, M.-O.; Dubois, B.; George, N.

10.1101/2022.02.04.479130 — neuroscience — Posted on 2022-02-07

2854 Genome-wide identification, characterization, and comparative analysis of NLR resistance genes in Coffea spp.

Santos, M. d. L.; de Resende, M. L. V.; Alves, G. S. C.; Huguet-Tapia, J. C.; de Resende, M. F. R.; Brawner, J. T.

10.1101/2022.02.03.478062 — plant biology — Posted on 2022-02-07

2855 Testing for phylogenetic signal in single-cell RNA-seq data

Moravec, J. C.; Lanfear, R.; Spector, D.; Diermeier, S.; Gavryushkin, A.

10.1101/2021.01.07.425804 — cancer biology — Posted on 2022-02-07

2856 Mutations of Omicron variant at the interface of the receptor domain motif and human angiotensin-converting enzyme-2

Adhikari, P.; Jawad, B.; Podgornik, R.; Ching, W.-Y.

10.1101/2022.02.04.479136 — biophysics — Posted on 2022-02-07

2857 A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

Shrimp, J. H.; Janiszewski, J.; Chen, C. Z.; Xu, M.; Wilson, K. M.; Kales, S. C.; Sanderson, P. E.; Shinn, P.; Itkin, Z.; Guo, H.; Shen, M.; Klumpp-Thomas, C.; Michael, S. G.; Zheng, W.; Simeonov, A.; Hall, M. D.

10.1101/2022.02.04.479134 — biochemistry — Posted on 2022-02-07

2858 Physiological and genetic drivers underpinning canopy development are associated with durum wheat yield in rainfed environments

Kang, Y.; Haeften, S. V.; Bustos-Korts, D.; Vukasovic, S.; Khan, S. U.; Dinglasan, E.; Christopher, J.; Chenu, K.; Able, J. A.; Smith, M. R.; Voss-Fels, K. P.; Potgieter, A. B.; Jordan, D. R.; Borrell, A. K.; Alahmad, S.; Hickey, L. T.

10.1101/2021.08.21.457180 — genetics — Posted on 2022-02-07

2859 α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain

Ho, M. T.; Lu, J.; Vazquez-Pianzola, P.; Suter, B.

10.1101/2019.12.19.882530 — cell biology — Posted on 2022-02-07

2860 Comparative analysis of cell-cell communication at single-cell resolution

Wilk, A. J.; Shalek, A. K.; Holmes, S. P.; Blish, C. A.

10.1101/2022.02.04.479209 — cell biology — Posted on 2022-02-07

2861 A reference induced pluripotent stem cell line for large-scale collaborative studies

10.1101/2021.12.15.472643 — neuroscience — Posted on 2022-02-07

2862 In vitro effect of a non-immunosuppressive FKBP ligand, FK1706, on SARS-CoV-2 replication in combination with antivirals

Fitzsimmons, W.; Hartman, T. L.; Mendenhall, M.; Chen, C.

10.1101/2022.02.03.479080 — pharmacology and toxicology — Posted on 2022-02-07

2863 Uncertainty and precaution in hunting wolves twice in a year

Treves, A.; Louchouarn, N. X.

10.1101/2021.10.25.465697 — ecology — Posted on 2022-02-07

2864 Predicting the re-distribution of antibiotic molecules caused byinter-species interactions in microbial communities

Reding, C.

10.1101/2020.12.14.422780 — microbiology — Posted on 2022-02-07

2865 Influence of delayed density and ultraviolet radiation on caterpillar baculovirus infection and mortality

Pepi, A.; Pan, V.; Rutkowski, D.; Mase, V.; Karban, R.

10.1101/2021.03.22.436482 — ecology — Posted on 2022-02-07

2866 Estimating the rate of plasmid transfer with an adapted Luria-Delbrück fluctuation analysis

Kosterlitz, O.; Muniz Tirado, A.; Wate, C.; Elg, C.; Bozic, I.; Top, E. M.; Kerr, B.

10.1101/2021.01.06.425583 — microbiology — Posted on 2022-02-07

2867 Interaction among bacterial cells triggers exit from lag phase

Ardre, M. B. P.; Doulcier, G.; Brenner, N.; Rainey, P. B.

10.1101/2022.01.24.477561 — microbiology — Posted on 2022-02-07

2868 Effect of SSRI discontinuation on anxiety-like behaviours in mice

Collins, H. M.; Pinacho, R.; Ozdemir, D.; Bannerman, D. M.; Sharp, T.

10.1101/2021.05.29.446266 — neuroscience — Posted on 2022-02-07

2869 High-throughput cryo-EM structure determination of amyloids

Lövestam, S.; Scheres, S.

10.1101/2022.02.07.479378 — biophysics — Posted on 2022-02-07

2870 A novel 5 prime DNA binding site in RFC facilitates PCNA loading for gap DNA repair

Zheng, F.; Georgescu, R. E.; Yao, N. Y.; Li, H.; O'Donnell, M. E.

10.1101/2022.02.04.479194 — biochemistry — Posted on 2022-02-07

2871 The initial response of females towards congeneric males matches the propensity to hybridise in Ophthalmotilapia.

Van Steenberge, M.; Jublier, N.; Kever, L.; Gresham, S.; Derycke, S.; Snoeks, J.; Parmentier, E.; Poncin, P.; Verheyen, E.

10.1101/2021.08.07.455508 — animal behavior and cognition — Posted on 2022-02-07

2872 Priority conservation areas and a global population estimate for the Critically Endangered Philippine Eagle derived from modelled range metrics using remote sensing habitat characteristics

Sutton, L. J.; Ibanez, J. C.; Salvador, D. I.; Taraya, R. L.; Opiso, G. S.; Senarillos, T. L. P.; McClure, C. J.

10.1101/2021.11.29.470363 — ecology — Posted on 2022-02-07

2873 FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells

Naillat, F.; Sharma, A.; Iber, D.; Meer, M.; Dapkunas, A.; Ihermann-Hella, A.; Kuure, S.; Vainio, S. J.

10.1101/2022.02.07.478973 — developmental biology — Posted on 2022-02-07

2874 A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution

Ijaz, F.; Nakazato, R.; Setou, M.; Ikegami, K.

10.1101/2022.02.07.479376 — cell biology — Posted on 2022-02-07

2875 Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

Unlu, G.; Prizer, B.; Erdal, R.; Yeh, H.-W.; Bayraktar, E. C.; Birsoy, K.

10.1101/2022.02.06.479330 — cell biology — Posted on 2022-02-07

2876 Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.

Sigmund, A. M.; Winkler, M.; Engelmayer, S.; Egu, D. T.; Kugelmann, D.; Radeva, M. Y.; Bayerbach, F. C.; Kotschi, S.; Yeruva, S.; Schmidt, E.; Yazdi, A. S.; Ghoreschi, K.; Vielmuth, F.; Waschke, J.

10.1101/2022.02.07.478931 — cell biology — Posted on 2022-02-07

2877 Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

Xia, F.; Ma, Y.; Chen, K.; Duong, B.; Ahmed, S.; Atwal, R.; Philpott, D.; Ketela, T.; Pantea, J.; Lin, S.; Angers, S.; Kelley, S.

10.1101/2021.08.20.457126 — cancer biology — Posted on 2022-02-07

2878 The optimal docking strength for reversibly tethered kinases

Dyla, M.; Gonzalez Foutel, N. S.; Otzen, D. E.; Kjaergaard, M.

10.1101/2022.02.07.479365 — biophysics — Posted on 2022-02-07

2879 The chromosomal distribution of sex-biased microRNAs in Drosophila is non-adaptive

Marco, A.

10.1101/2021.09.25.461796 — evolutionary biology — Posted on 2022-02-07

2880 A transcytotic actin shift polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains

Jafari, G.; Khan, L. A.; Zhang, H.; Membreno, E.; Yan, S.; Gobel, V.

10.1101/2022.02.06.479326 — cell biology — Posted on 2022-02-07

2881 Adenine Base Editing in vivo with a Single Adeno-Associated Virus Vector

Zhang, H.; Bamidele, N.; Liu, P.; Ojelabi, O.; Gao, X. D.; Rodriguez, T.; Cheng, H.; Xie, J.; Gao, G.; Wolfe, S. A.; Xue, W.; Sontheimer, E. J.

10.1101/2021.12.13.472434 — molecular biology — Posted on 2022-02-07

2882 Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Simola, J.; Siebenhühner, F.; Myrov, V.; Kantojärvi, K.; Paunio, T.; Palva, J. M.; Brattico, E.; Palva, S.

10.1101/2021.11.16.468778 — neuroscience — Posted on 2022-02-07

2883 Novel cerebello-amygdala connections provide missing link between cerebellum and limbic system

Jung, S. J.; Vlasov, K.; D'Ambra, A. F.; Parigi, A.; Baya, M.; Frez, E. P.; Villalobos, J.; Fernandez Frentzel, M.; Anguiano, M.; Ideguchi, Y.; Antzoulatos, E. G.; Fioravante, D.

10.1101/2022.02.07.479043 — neuroscience — Posted on 2022-02-07

2884 Rhythmic interactions between the mediodorsal thalamus and prefrontal cortex precede human visual perception

Griffiths, B. J.; Zaehle, T.; Repplinger, S.; Schmitt, F.; Voges, J.; Hanslmayr, S.; Staudigl, T.

10.1101/2022.02.07.479362 — neuroscience — Posted on 2022-02-07

2885 Dynamic distortion of orientationrepresentation after learning in the mouseprimary visual cortex

Corbo, J.; McClure, J. P.; Erkat, O. B.; Polack, P.-O.

10.1101/2021.03.25.437032 — neuroscience — Posted on 2022-02-07

2886 Emergence of Heartbeat Frailty in Advanced Age: Perspectives from Life-Long EKG Recordings in Mice

Moen, J. M.; Morrell, C. H.; Ahmet, I.; Matt, M. G.; Davoodi, M.; Petr, M.; Charles, S.; deCabo, R.; Yaniv, Y.; Lakatta, E. G.

10.1101/2022.01.12.475659 — physiology — Posted on 2022-02-07

2887 Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

Xia, B.; Wang, Y.; Pan, X.; Cheng, X.; Ji, H.; Zuo, X.; Li, J.; Gao, Z.

10.1101/2022.02.01.478647 — microbiology — Posted on 2022-02-07

2888 SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

Samudyata, ; Oliveira, A. O.; Malwade, S.; de Sousa, N. R.; Goparaju, S. K.; Orhan, F.; Steponaviciute, L.; Schalling, M.; Sheridan, S. D.; Perlis, R. H.; Rothfuchs, A. G.; Sellgren-Majkowitz, C.

10.1101/2021.07.07.451463 — neuroscience — Posted on 2022-02-07

2889 M-Phase oscillations in PP1 activity are essential for accurate progression through mammalian oocyte meiosis

Camlin, N. J.; Venkatachalam, I.; Evans, J. P.

10.1101/2021.09.28.461976 — molecular biology — Posted on 2022-02-07

2890 Covariance predicts conserved protein residue interactions important to the emergence and continued evolution of SARS-CoV-2 as a human pathogen

Robins, W. P.; Mekalanos, J. J.

10.1101/2022.01.13.476204 — microbiology — Posted on 2022-02-07

2891 Towards a unified model of naive T cell dynamics across the lifespan

Rane, S.; Hogan, T.; Lee, E.; Seddon, B.; Yates, A.

10.1101/2022.01.07.475400 — immunology — Posted on 2022-02-07

2892 Simple Model for Encoding Natural Images by Retinal Ganglion Cells with Nonlinear Spatial Integration

Liu, J. K.; Karamanlis, D.; Gollisch, T.

10.1101/2021.08.29.458067 — neuroscience — Posted on 2022-02-07

2893 Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression

LI, Q.; Takeuchi, Y.; Wang, J.; Barcsai, L.; Pedraza, L. K.; Kozak, G.; Nakai, S.; Kato, S.; Kobayashi, K.; Ohsawa, M.; Lorincz, M. L.; Devinsky, O.; Buzsaki, G.; Berenyi, A.

10.1101/2022.02.01.478683 — neuroscience — Posted on 2022-02-07

2894 Clustered cortical inhibition confers robust balance and explains variability dynamics and reaction times during motor task performance

Rostami, V.; Rost, T.; Riehle, A.; van Albada, S. J.; P. Nawrot, M.

10.1101/2020.02.27.968339 — neuroscience — Posted on 2022-02-07

2895 Single-cell analysis reveals cellular heterogeneity and molecular determinants of hypothalamic leptin-receptor cells

Kakava Georgiadou, N.; Severens, J.; Moltke-Jorgense, A.; Stoltenborg, I.; Garner, K. M.; Luijendijk-Berg, M. C. M.; Drkelic, V.; van Dijk, R. E.; Dickson, S. L.; Pers, T. H.; Basak, O.; Adan, R. A. H.

10.1101/2020.07.23.217729 — neuroscience — Posted on 2022-02-07

2896 Corticostriatal dynamics underlying components of binge-like eating in mice

Hildebrandt, B. A.; Fisher, H.; LaPalombara, Z.; Young, M. E.; Ahmari, S. E.

10.1101/2021.11.04.467011 — neuroscience — Posted on 2022-02-07

2897 Genetic architecture of natural variation of cardiac performance in flies

Saha, S.; Spinelli, L.; Castro-Mondragon, J. A.; Kervadec, A.; Kremmer, L.; Roder, L.; Krifa, S.; Torres, M.; Brun, C.; Vogler, G.; Bodmer, R.; COLAS, A.; Ocorr, K.; Perrin, L.

10.1101/2021.06.08.447524 — genetics — Posted on 2022-02-07

2898 Compressive forces stabilise microtubules in living cells

Li, Y.; Kucera, O.; Cuvelier, D.; Rutkowski, D. M.; Deygas, M.; Rai, D.; Pavlovic, T.; Vicente, F. N.; Piel, M.; Giannone, G.; Vavylonis, D.; Akhmanova, A.; Blanchoin, L.; Thery, M.

10.1101/2022.02.07.479347 — cell biology — Posted on 2022-02-07

2899 Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A2 and daptomycin.

Kuijk, M. M.; Wu, Y.; van Hensbergen, V. P.; Shanlitourk, G.; Payre, C.; Lambeau, G.; Herrmann, J.; Müller, R.; van Strijp, J. A. G.; Pannekoek, Y.; Touqui, L.; van Sorge, N. M.

10.1101/2022.02.06.476181 — microbiology — Posted on 2022-02-07

2900 Mechanistic insights into global suppressors of protein folding defects

Chattopadhyay, G.; Bhowmick, J.; Manjunath, K.; Ahmed, S.; Goyal, P.; Varadarajan, R.

10.1101/2021.11.18.469098 — biophysics — Posted on 2022-02-07

2901 MetaLogo: a heterogeneity-aware sequence logo generator and aligner

Chen, Y.; He, Z.; Men, Y.; Dong, G.; Hu, S.; Ying, X.

10.1101/2021.08.12.456038 — bioinformatics — Posted on 2022-02-07

2902 Characterization of peptide-protein relationships in protein ambiguity groups via bipartite graphs

Schork, K.; Turewicz, M.; Uszkoreit, J.; Rahnenführer, J.; Eisenacher, M.

10.1101/2021.07.28.454128 — bioinformatics — Posted on 2022-02-07

2903 GRaNIE and GRaNPA: Inference and evaluation of enhancer-mediated gene regulatory networks applied to study macrophages

Kamal, A.; Arnold, C.; Claringbould, A.; Moussa, R.; Daga, N.; Nogina, D.; Kholmatov, M.; Servaas, N.; Mueller-Dott, S.; Reyes-Palomares, A.; Palla, G.; Sigalova, O.; Bunina, D.; Pabst, C.; Zaugg, J. B.

10.1101/2021.12.18.473290 — genomics — Posted on 2022-02-07

2904 Mutualists construct the ecological conditions that trigger the transition from parasitism

Ledru, L.; Garnier, J.; Rohr, M.; Nous, C.; Ibanez, S.

10.1101/2021.08.18.456759 — evolutionary biology — Posted on 2022-02-07

2905 metaPR2: a database of eukaryotic 18S rRNA metabarcodes with an emphasis on protists.

Vaulot, D.; Sim, C. W. H.; Ong, D.; Teo, B.; Biwer, C.; Jamy, M.; Lopes dos Santos, A.

10.1101/2022.02.04.479133 — ecology — Posted on 2022-02-07

2906 Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria

Glover, G.; Voliotis, M.; Lapinska, U.; Invergo, B.; Soanes, D.; O'Neill, P.; Moore, K.; Nikolic, N.; Petrov, P.; Milner, D.; Roy, S.; Heesom, K.; Richards, T.; Tsaneva-Atanasova, K.; Pagliara, S.

10.1101/2022.01.26.477826 — microbiology — Posted on 2022-02-07

2907 Re-sensitising XDR biofilms using a combination of bacteriophage cocktails and colistin: a natural approach

Devanga Ragupathi, N. K.; Muthuirulandi Sethuvel, D. P.; Gopikrishnan, M.; Murugan, D.; Juliet, R.; Majhi, M.; Murugesan, M.; C, G. P. D.; Wannigama, L.; Monk, P. N.; Karunakaran, E.; Veeraraghavan, B.

10.1101/2022.02.04.479063 — microbiology — Posted on 2022-02-07

2908 Dynamical management of potential threats regulated by dopamine and direct- and indirect-pathway neurons in the tail of the striatum

Tsutsui-Kimura, I.; Uchida, N.; Watabe-Uchida, M.

10.1101/2022.02.05.479267 — neuroscience — Posted on 2022-02-07

2909 Human foraging for primary rewards is guided by fronto-hippocampal dynamics of anticipation

Shintaki, R.; Tanaka, D.; Suzuki, S.; Yoshimoto, T.; Sadato, N.; Chikazoe, J.; Jimura, K.

10.1101/2021.11.16.468916 — neuroscience — Posted on 2022-02-07

2910 Strong and localized recurrence controlsdimensionality of neural activity across brainareas

Dahmen, D.; Recanatesi, S.; Jia, X.; Ocker, G. K.; Campagnola, L.; Jarsky, T.; Seeman, S.; Helias, M.; Shea-Brown, E.

10.1101/2020.11.02.365072 — neuroscience — Posted on 2022-02-07

2911 The dynamic range of voltage-dependent gap junction signaling is maintained by Ih-induced membrane potential depolarization

Stein, W.; DeMaegd, M.; Braun, L. Y.; Vidal-Gadea, A. G.; Harris, A. L.; Städele, C.

10.1101/2021.12.16.472972 — neuroscience — Posted on 2022-02-07

2912 Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

Szego, E. M.; Malz, L.; Bernhardt, N.; Roesen-Wolff, A.; Falkenburger, B. H.; Luksch, H.

10.1101/2022.02.02.478854 — neuroscience — Posted on 2022-02-07

2913 Modulation of stress-related behaviour by hypothalamic engagement of preproglucagon neurons in the nucleus of the solitary tract

Holt, M. K.; Valderrama, N.; Polanco, M. J.; Rinaman, L.

10.1101/2022.02.04.479117 — neuroscience — Posted on 2022-02-07

2914 microRNA-138 controls hippocampal interneuron function and short-term memory

Schratt, G.; Daswani, R.; Gilardi, C.; Soutschek, M.; Weiss, K.; Bicker, S.; Fiore, R.; Dieterich, C.; Germain, P.-L.; Winterer, J.; Nanda, P.

10.1101/2021.05.12.443573 — neuroscience — Posted on 2022-02-07

2915 Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves

Ringers, C.; Bialonski, S.; Solovev, A.; Hansen, J. N.; Ege, M.; Friedrich, B. M.; Jurisch-Yaksi, N.

10.1101/2021.11.23.469646 — biophysics — Posted on 2022-02-07

2916 Bidirectional crosstalk between epithelial-mesenchymal plasticity and IFNγ-induced PD-L1 expression promotes tumor progression

Burger, G. A.; Nesenberend, D. N.; Lems, C. M.; Hille, S. C.; Beltman, J. B.

10.1101/2022.02.03.478950 — systems biology — Posted on 2022-02-06

2917 Dissecting the co-transcriptome landscape of plants and microbiota members

Nobori, T.; Cao, Y.; Entila, F.; Dahms, E.; Tsuda, Y.; Garrido-Oter, R.; Tsuda, K.

10.1101/2021.04.25.440543 — plant biology — Posted on 2022-02-06

2918 Native Metabolomics Identifies the Rivulariapeptolide Family of Protease Inhibitors

Reher, R.; Aron, A. T.; Fajtova, P.; Stincone, P.; Liu, C.; Ben Shalom, I. Y.; Bittremieux, W.; Wang, M.; Matos-Hernandez, M. L.; Alexander, K. L.; Caro-Diaz, E. J.; Naman, C. B.; Hughes, C. C.; Dorrestein, P. C.; O'Donoghue, A. J.; Gerwick, W. H.; Petras, D.

10.1101/2021.09.03.458897 — systems biology — Posted on 2022-02-06

2919 Espalier: Efficient tree reconciliation and ARG reconstruction using maximum agreement forests

Rasmussen, D. A.; Guo, F.

10.1101/2022.01.17.476639 — evolutionary biology — Posted on 2022-02-06

2920 Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments

Shen, B. A.; Hustmyer, C. M.; Roston, D.; Wolfe, M. B.; Landick, R.

10.1101/2020.06.11.146589 — molecular biology — Posted on 2022-02-06

2921 Single-molecule imaging reveals Tau trapping at nanometer-sized dynamic hot spots near the plasma membrane

Padmanabhan, P.; Kneynsberg, A.; Gonzalez, E. C.; Amor, R.; Sibarita, J.-B.; Götz, J.

10.1101/2022.02.04.479198 — neuroscience — Posted on 2022-02-06

2922 The human brain networks mediating the vestibular sensation of self-motion

Hadi, Z.; Pondeca, Y. J.; Calzolari, E.; Mahmud, M. S.; Chepisheva, M. K.; Smith, R. M.; Rust, H.; Sharp, D. J.; Seemungal, B. M.

10.1101/2021.12.03.471139 — neuroscience — Posted on 2022-02-06

2923 AI reveals insights into link between CD33 and cognitive impairment in Alzheimer's Disease

Raschka, T.; Sood, M.; Schultz, B.; Altay, A.; Ebeling, C.; Fröhlich, H.

10.1101/2022.02.04.479087 — systems biology — Posted on 2022-02-06

2924 Quantitative modeling of pentose phosphate pathway response to oxidative stress reveals a cooperative regulatory strategy

Hurbain, J.; Thommen, Q.; Anquez, F.; Pfeuty, B.

10.1101/2022.02.04.478659 — systems biology — Posted on 2022-02-06

2925 An unbiased pathway analysis (UPA) designed for multi-omics inference of cell signaling pathways

Vaparanta, K.; Merilahti, J. A. M.; Ojala, V. K.; Elenius, K.

10.1101/2022.02.05.479228 — systems biology — Posted on 2022-02-06

2926 Genome-microbiome interplay provides insight into the determinants of the human blood metabolome

Diener, C.; Dai, C. L.; Wilmanski, T.; Baloni, P.; Smith, B.; Rappaport, N.; Hood, L.; Magis, A. T.; Gibbons, S. M.

10.1101/2022.02.04.479172 — systems biology — Posted on 2022-02-06

2927 Cell-type specific transcriptional networks in root xylem adjacent cell layers

Asensi Fabado, M. A.; Armstrong, E. A.; Walker, L.; Perrella, G.; Hamilton, G.; Herzyk, P.; Gifford, M. L.; Amtmann, A.

10.1101/2022.02.04.479129 — plant biology — Posted on 2022-02-06

2928 Expectation for sweet taste changes peripheral glucose metabolism via basolateral amygdala

Yamamoto, I.; Yonekura, T.; Ishimoto, T.; Xu, S.-C.; Iijima, N.; Kimura, K.; Diano, S.; Toda, C.

10.1101/2022.02.03.479066 — physiology — Posted on 2022-02-06

2929 Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain

Glassman, P. M.; Nong, J.; Myerson, J. W.; Zuluaga-Ramirez, V.; Rodriguez-Garcia, A.; Mukalel, A.; Omo-Lamai, S.; Walsh, L. R.; Kiseleva, R. Y.; Villa, C. H.; Greineder, C. F.; Kasner, S. E.; Weissman, D.; Mitchell, M. J.; Muro, S.; Persidsky, Y.; Brenner, J. S.; Muzykantov, V. R.; Marcos-Contreras, O. A.

10.1101/2022.02.04.479150 — pharmacology and toxicology — Posted on 2022-02-06

2930 Reconstructing phylogeny of the hornless rhinoceros Aceratheriinae

lu, X.; Deng, T.; Pandolfi, L.

10.1101/2022.02.04.478979 — paleontology — Posted on 2022-02-06

2931 Complex genotype-phenotype relationships shape the response to treatment of Down Syndrome Childhood Acute Lymphoblastic Leukaemia

Lutz, C.; Turati, V. A.; Clifford, R.; Woll, P. S.; Stiehl, T.; Castor, A.; Clark, S. A.; Ferry, H.; Buckle, V.; Trumpp, A.; Ho, A.; Marciniak-Czochra, A.; Herrero, J.; Schuh, A.; Jacobsen, S. E. W.; Enver, T.

10.1101/2022.02.06.479302 — cancer biology — Posted on 2022-02-06

2932 Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism

Wu, T.; Wu, C.; Zhao, X.; Wang, G.; Ning, W.; Tao, Z.; Chen, F.; Liu, X.-S.

10.1101/2022.02.04.479205 — cancer biology — Posted on 2022-02-06

2933 Equilibrium dynamics of the pre- and post-cleavage regions of SP1 are separately shifted by the HIV-1 maturation inhibitor Bevirimat

Xu, C.; Perilla, J. R.

10.1101/2022.02.05.479246 — biophysics — Posted on 2022-02-06

2934 An Oscillatory Shear Index-based Model to Describe Progressive Carotid Artery Stenosis

Patalano, P.

10.1101/2022.02.04.479106 — bioinformatics — Posted on 2022-02-06

2935 Local extensional flows promote long-range fiber alignment in 3D collagen hydrogels

Ahmed, A.; Joshi, I. M.; Mansouri, M.; Byerley, A. M.; Day, S. W.; Gaborski, T. R.; Abhyankar, V. V.

10.1101/2022.02.04.479166 — bioengineering — Posted on 2022-02-06

2936 Annelid functional genomics reveal the origins of bilaterian life cycles

Liang, Y.; Martin-Zamora, F. M.; Guynes, K.; Carrillo-Baltodano, A.; Tan, Y.; Moggioli, G.; Seudre, O.; Tran, M.; Mortimer, K.; Luscombe, N.; Hejnol, A.; Marletaz, F.; Martin-Duran, J. M.

10.1101/2022.02.05.479245 — genomics — Posted on 2022-02-06

2937 Genetic and genomic analysis of oxygen consumption in mice

Ogawa, S.; Darhan, H.; Suzuki, K.

10.1101/2022.02.05.479269 — genetics — Posted on 2022-02-06

2938 Evolutionary quantitative proteomics of reproductive interactions in Drosophila

Garlovsky, M. D.; Ahmed-Braimah, Y. H.

10.1101/2022.02.04.479202 — evolutionary biology — Posted on 2022-02-06

2939 Delimiting Continuity: Comparison of Target Enrichment and ddRAD for Delineating Admixing Parapatric Melitaea Butterflies

Joshi, M.; Espeland, M.; Dinca, V. E.; Vila, R.; Tahami, M. S.; Dietz, L.; Mayer, C.; Martin, S.; Dapporto, L.; Mutanen, M.

10.1101/2022.02.05.479083 — evolutionary biology — Posted on 2022-02-06

2940 metaPR2: a database of eukaryotic 18S rRNA metabarcodes with an emphasis on protists.

Vaulot, D.; Sim, C. W. H.; Ong, D.; Teo, B.; Biwer, C.; Jamy, M.; Lopes dos Santos, A.

10.1101/2022.02.04.479133 — ecology — Posted on 2022-02-06

2941 Heteractis magnifica Sea Anemone Population Dynamics at Village Reef, Perhentian Kecil, Malaysia: Monitoring of Growth, Formations, and Hosting Status.

Versteeg, M.; Halid, H.; Campbell, A.

10.1101/2022.02.04.479141 — ecology — Posted on 2022-02-06

2942 Exploring Genomic Conservation in Actinobacteriophages with Small Genomes

Tse, V. Y.; Liu, H.; Kapinos, A.; Torres, C.; Rahman, M.; Vargas, A. S.; Cayabyab, B. C. S.; Nakashima, L. G.; Fett, S. N.; Reddi, K.; Moberg Parker, J.; Freise, A. C.

10.1101/2022.02.05.479200 — microbiology — Posted on 2022-02-06

2943 Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress

Babosan, A.; Fruchard, L.; Krin, E.; Carvalho, A.; Mazel, D.; Baharoglu, Z.

10.1101/2022.02.06.479318 — microbiology — Posted on 2022-02-06

2944 The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane

Felix, J.; Bumba, L.; Liesche, C.; Fraudeau, A.; Rebeille, F.; El Khoury, J.; Huard, K.; Gallet, B.; Moriscot, C.; Kleman, J.-P.; Duhoo, Y.; Jessop, M.; Kandiah, E.; Barras, F.; Jouhet, J.; Gutsche, I.

10.1101/2022.02.06.479298 — microbiology — Posted on 2022-02-06

2945 Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models

Farrell, M. R.; Ye, Q.; Xie, Y.; Esteban, J. S. D.; Mahler, S. V.

10.1101/2022.02.03.479042 — neuroscience — Posted on 2022-02-06

2946 Human Cerebral Spheroids Undergo Activity Dependent Changes In Cellular Composition And MicroRNA Expression

Parmentier, T.; James, F. M. K.; Hewitson, E.; Bailey, C. D. C.; Werry, N.; Sheridan, S. D.; Perlis, R. H.; Perreault, M.; Gaitero, L.; Lalonde, J.; LaMarre, J.

10.1101/2022.02.04.478858 — neuroscience — Posted on 2022-02-06

2947 Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson's disease

Vidyadhara, D. J.; Somayaji, M.; Wade, N.; Yücel, B.; Zhao, H.; Shashaank, N.; Ribaudo, J.; Gupta, J.; Lam, T. T.; Sames, D.; Greene, L. E.; Sulzer, D. L.; Chandra, S. S.

10.1101/2022.02.04.479203 — neuroscience — Posted on 2022-02-06

2948 Abnormal brain state distribution and network connectivity in a SYNGAP1 rat model

Buller-Peralta, I.; Maicas-Royo, J.; Lu, Z.; Till, S. M.; Wood, E. R.; Kind, P. C.; Escudero, J.; Gonzalez-Sulser, A.

10.1101/2022.02.04.479013 — neuroscience — Posted on 2022-02-06

2949 Speech understanding oppositely affectsacoustic and linguistic neural tracking in aspeech rate manipulation paradigm.

Verschueren, E.; Gillis, M.; Vanthornhout, J.; Decruy, L.; Francart, T.

10.1101/2022.02.04.479105 — neuroscience — Posted on 2022-02-06

2950 Sensitisation of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity

Barker, K. H.; Higham, J. P.; Pattison, L. A.; Taylor, T. S.; Chessell, I. P.; Welsh, F.; Smith, E. S. J.; Bulmer, D. C.

10.1101/2022.02.06.478183 — neuroscience — Posted on 2022-02-06

2951 Early removal of the infrapatellar fat pad pad beneficially alters the pathogenesis of moderate stage idiopathic knee osteoarthritis in the Dunkin Hartley guinea pig

Afzali, M. F.; Radakovich, L.; Campbell, M. A.; Sanford, J. L.; Sykes, M. M.; Marolf, A. J.; Donahue, T. H.; Susan, K. S.

10.1101/2022.02.04.479182 — pathology — Posted on 2022-02-06

2952 Towards Effective and Generalizable Fine-tuning for Pre-trained Molecular Graph Models

XIA, J.; Zheng, J.; Tan, C.; Wang, G.; Li, S. Z.

10.1101/2022.02.03.479055 — bioinformatics — Posted on 2022-02-06

2953 CDMAP/CDVIS: Context-dependent Mutation Analysis Package and Visualization Software

Patton, D. L.; Mele, P.; Navarro, J.; Cardenas, T.; Sung, W.

10.1101/2022.02.03.479067 — bioinformatics — Posted on 2022-02-06

2954 Genomic neighbor typing for bacterial outbreaksurveillance

Steinig, E.; Pitt, M.; Aglua, I.; Suttie, A.; Greenhill, A.; Heather, C.; Firth, C.; Smith, S.; Pomat, W.; Horwood, P.; McBryde, E.; Coin, L.

10.1101/2022.02.05.479210 — bioinformatics — Posted on 2022-02-06

2955 Optocoder: computational decoding of spatially indexed bead arrays

Senel, E.; Rajewsky, N.; Karaiskos, N.

10.1101/2022.02.04.478148 — bioinformatics — Posted on 2022-02-06

2956 Multiplexed Detection of Molecular Interactions with DNA Origami Engineered Cells in 3-D Collagen Matrices

Shahhosseini, M.; Beshay, P.; Akbari, E.; Avendano, A.; Song, J. W.; Castro, C.

10.1101/2022.02.04.479158 — bioengineering — Posted on 2022-02-06

2957 Inhibition of a critical malaria host-pathogen interaction by a computationally designed inhibitor targeting Plasmodium vivax DBP

Tobin, A. R.; Crow, R.; Urusova, D. V.; Klima, J. C.; Tolia, N. H.; Strauch, E.-M. M.

10.1101/2022.02.05.479252 — bioengineering — Posted on 2022-02-06

2958 Uncovering the hologenomic basis of an extraordinary plant invasion

Bieker, V. C.; Battlay, P.; Petersen, B.; Sun, X.; Wilson, J.; Brealey, J. C.; Bretagnolle, F.; Nurkowski, K.; Lee, C.; Owens, G. L.; Lee, J. Y.; Kellner, F. L.; van Boheeman, L.; Gopalakrishnan, S.; Gaudeul, M.; Mueller-Schaerer, H.; Karrer, G.; Chauvel, B.; Sun, Y.; Dalen, L.; Poczai, P.; Rieseberg, L. H.; Gilbert, M. T. P.; Hodgins, K. A.; Martin, M. D.

10.1101/2022.02.03.478494 — genomics — Posted on 2022-02-06

2959 Interdisciplinary analyses of Bronze Age communities from Western Hungary reveal complex population histories

Gerber, D.; Szeifert, B.; Szekely, O.; Egyed, B.; Gyuris, B.; Giblin, J. I.; Horvath, A.; Palcsu, L.; Kohler, K.; Kulcsar, G.; Kustar, A.; Szeverenyi, V.; Fabian, S.; Mende, B. G.; Bondar, M.; Ari, E.; Kiss, V.; Szecsenyi-Nagy, A.

10.1101/2022.02.03.478968 — genomics — Posted on 2022-02-06

2960 Idiosyncratic fitness costs of ampicillin-resistant mutants derived from a long-term experiment with Escherichia coli

Jordan, J. A.; Lenski, R. E.; Card, K. J.

10.1101/2022.02.06.479266 — evolutionary biology — Posted on 2022-02-06

2961 Body mass and latitude as global predictors of vertebrate populations exposure to multiple threats

Capdevila, P.; Noviello, N.; McRae, L.; Freeman, R.; Clements, C. F.

10.1101/2022.02.04.479091 — ecology — Posted on 2022-02-06

2962 Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells.

Zareifard, A.; Beaudry, F.; Ndiaye, K.

10.1101/2022.02.05.479268 — molecular biology — Posted on 2022-02-06

2963 Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A2 and daptomycin.

Kuijk, M. M.; Wu, Y.; van Hensbergen, V. P.; Shanlitourk, G.; Payre, C.; Lambeau, G.; Herrmann, J.; Müller, R.; van Strijp, J. A. G.; Pannekoek, Y.; Touqui, L.; van Sorge, N. M.

10.1101/2022.02.06.476181 — microbiology — Posted on 2022-02-06

2964 Experimental Suppression of TMS-EEG Sensory Potentials

Ross, J. M.; Sarkar, M.; Keller, C. J.

10.1101/2022.02.02.478881 — neuroscience — Posted on 2022-02-06

2965 Abnormal molecular signatures of inflammation, energy metabolism and vesicle biology in human Huntington disease peripheral tissues

Neueder, A.; Kojer, K.; Hering, T.; Lavery, D. J.; Chen, J.; Birth, N.; Hallitsch, J.; Trautmann, S.; Parker, J.; Flower, M.; Sethi, H.; Haider, S.; Lee, J.-M.; Tabrizi, S. J.; Orth, M.

10.1101/2022.02.03.475821 — neuroscience — Posted on 2022-02-06

2966 Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE

Borges, F. d. S.; Moreira, J. V. S.; Takarabe, L. M.; Lytton, W. W.; Dura-Bernal, S.

10.1101/2022.02.03.479029 — neuroscience — Posted on 2022-02-06

2967 Recurrent circuits amplify corticofugal signals and drive feed-forward inhibition in the inferior colliculus

Oberle, H. M.; Ford, A. N.; Apostolides, P. F.

10.1101/2022.02.03.478995 — neuroscience — Posted on 2022-02-06

2968 Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics

Dura-Bernal, S.; Griffith, E. Y.; Barczak, A.; O'Connell, M. N.; McGinnis, T.; Schroeder, C. E.; Lytton, W. W.; Lakatos, P.; Neymotin, S. A.

10.1101/2022.02.03.479036 — neuroscience — Posted on 2022-02-06

2969 Multiplex imaging of human induced pluripotent stem cell-derived neurons with CO-Detection by indEXing (CODEX) technology

Heinrich, L.; Zafar, F.; Morato-Torres, A.; Singh, J.; Khan, A.; Chen, M. Y.; Hempel, C.; Nikulina, N.; Mulholland, J.; Braubach, O.; Schuele, B.

10.1101/2022.02.03.479039 — neuroscience — Posted on 2022-02-06

2970 Tau seeding without tauopathy

LaCroix, M. S.; Hitt, B. D.; Beaver, J. D.; Terpack, S. J.; Gleason, K.; Tamminga, C. A.; Evers, B. M.; White, C. L.; Diamond, M. I.

10.1101/2022.02.03.479049 — neuroscience — Posted on 2022-02-06

2971 Multiscale model of primary motor cortex circuits reproduces in vivo cell type-specific dynamics associated with behavior

Dura-Bernal, S.; Neymotin, S. A.; Suter, B. A.; Dacre, J.; Schiemann, J.; Duguid, I.; Shepherd, G. M. G.; Lytton, W. W.

10.1101/2022.02.03.479040 — neuroscience — Posted on 2022-02-06

2972 Interferon regulates stem cell output via post-transcriptional repression of Sox2 independent of its antiviral function in the brain

10.1101/2022.02.03.478954 — neuroscience — Posted on 2022-02-06

2973 Data-driven dynamical modelling of a pathogen-infected plant gene regulatory network: a comparative analysis

Foo, M.; Dony, L.; He, F.

10.1101/2022.02.03.479002 — systems biology — Posted on 2022-02-06

2974 DisPhaseDB, an integrative database of diseases related variations in liquid-liquid phase separation proteins

Navarro, A. M.; Orti, F.; Martinez-Perez, E.; Simonetti, F. L.; Iserte, J. A.; Marino-Buslje, C.

10.1101/2022.02.03.479026 — bioinformatics — Posted on 2022-02-06

2975 mcPBWT: Space-efficient Multi-column PBWT Scanning Algorithm for Composite Haplotype Matching

Shakya, P.; Naseri, A.; Zhi, D.; Zhang, S.

10.1101/2022.02.02.478879 — bioinformatics — Posted on 2022-02-06

2976 RaPID-Query for Fast Identity by Descent Search and Genealogical Analysis

Wei, Y.; Naseri, A.; Zhi, D.; Zhang, S.

10.1101/2022.02.03.478907 — bioinformatics — Posted on 2022-02-06

2977 Transfer Learning for Cognitive Reserve Quantification

Zhu, X.; Liu, Y.; Habeck, C. G.; Stern, Y.; Lee, S.

10.1101/2022.02.03.479059 — bioinformatics — Posted on 2022-02-06

2978 CRFalign: A Sequence-structure alignment of proteins based on a combinationof HMM-HMM comparison and conditional random fields

Lee, S. J.; Joo, K.; Sim, S.; Lee, J.; Lee, I.-H.; Lee, J.

10.1101/2022.02.03.478675 — bioinformatics — Posted on 2022-02-06

2979 Can the Kuznetsov Model Replicate and Predict Cancer Growth in Humans?

El Wajeh, M.; Jung, F.; Bongartz, D.; Kappatou, C. D.; Laleh, N. G.; Mitsos, A.; Kather, J. N.

10.1101/2022.02.02.478884 — bioinformatics — Posted on 2022-02-06

2980 An improved MS2-MCP imaging system with minimal perturbation of mRNA stability

Li, W.; Maekiniemi, A.; Sato, H.; Osman, C.; Singer, R. H.

10.1101/2022.02.05.479257 — cell biology — Posted on 2022-02-06

2981 Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model

Alonso, A.; Samanta, A.; van der Meij, J.; van den Brand, L.; Negwer, M.; Navarro Lobato, I.; Genzel, L.

10.1101/2022.02.03.478985 — neuroscience — Posted on 2022-02-06

2982 Preferential activation of proprioceptive and cutaneous sensory fibers compared to motor fibers during cervical transcutaneous spinal cord stimulation: A computational study

de Freitas, R. M.; Capogrosso, M.; Nomura, T.; Milosevic, M.

10.1101/2022.02.02.478757 — neuroscience — Posted on 2022-02-06

2983 Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Dumont, C.; Li, G.; Castel, J.; Luquet, S.; Gangarossa, G.

10.1101/2022.02.03.478953 — neuroscience — Posted on 2022-02-06

2984 Traveling waves in the monkey frontoparietal network predict recent reward memory

Zabeh, E.; Foley, N. C.; Jacobs, J.; Gottlieb, J.

10.1101/2022.02.03.478583 — neuroscience — Posted on 2022-02-06

2985 Reading instruction causes changes in category-selective visual cortex

Yeatman, J. D.; Caffarra, S.; Clark, M.; Ender, S. M.; Gijbels, L.; Joo, S. J.; Kubota, E. C.; Larson, E.; McCloy, D. R.; O'Brien, G.; Peterson, E. R.; Takada, M. E.; Taulu, S.

10.1101/2022.02.02.477919 — neuroscience — Posted on 2022-02-06

2986 Interference of Neuronal TrkB Signaling by the Cannabis-Derived Flavonoids Cannflavins A and B

Holborn, J.; Walczyk Mooradally, A.; Perrin, C.; Alural, B.; Aitchinson, C.; Khokhar, J.; Akhtar, T.; Lalonde, J.

10.1101/2022.02.03.478734 — pharmacology and toxicology — Posted on 2022-02-06

2987 Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Liu, Y.; Senatore, A.; Sorce, S.; Nuvolone, M.; Guo, J.; Gumus, Z. H.; Aguzzi, A.

10.1101/2022.02.06.479288 — neuroscience — Posted on 2022-02-06

2988 Distinct mechanisms of germ cell factor regulation for an inductive germ cell fate

Foster, S.; Oulhen, N.; Fresques, T.; Zaki, H.; Wessel, G. M.

10.1101/2022.02.04.479164 — developmental biology — Posted on 2022-02-06

2989 A Yap-dependent transcriptional program directs cell migration for embryo axis assembly

Sousa-Ortega, A.; Vazquez-Marin, J.; Sanabria-Reinoso, E.; Polvillo, R.; Campoy-Lopez, A.; Buono, L.; Loosli, F.; Almuedo-Castillo, M.; Martinez-Morales, J. R.

10.1101/2022.02.06.479280 — developmental biology — Posted on 2022-02-06

2990 Nociception-dependent CCL21 induce dorsal root ganglia axonal growth via CCR7-ERK activation

Mesquida-Veny, F.; Martinez-Torres, S.; del Rio, J. A.; Hervera Abad, A.

10.1101/2022.02.04.479124 — cell biology — Posted on 2022-02-06

2991 Chlamydomonas RABL4/IFT27 Mediates Phototaxis via Promoting BBSome-dependent Ciliary Export of Phospholipase D

Liu, Y.-X.; Xue, B.; Fan, Z.-C.

10.1101/2022.02.06.479262 — cell biology — Posted on 2022-02-06

2992 Disruption of miR-18a alters proliferation, photoreceptor replacement kinetics, inflammatory signaling and microglia/macrophage numbers during retinal regeneration in zebrafish

Magner, E.; Sandoval-Sanchez, P.; Kramer, A. C.; Thummel, R.; Hitchcock, P. F.; Taylor, S. M.

10.1101/2021.04.25.441353 — neuroscience — Posted on 2022-02-06

2993 A novel 5' DNA binding site in RFC facilitates PCNA loading for gap DNA repair

Zheng, F.; Georgescue, R.; Yao, N. Y.; Li, H.; O'Donnell, M. E.

10.1101/2022.02.04.479194 — biochemistry — Posted on 2022-02-06

2994 Locally synchronized ciliary domains and tissue-scale cilia alignment underlie global metachronal wave patterns

Ringers, C.; Bialonski, S.; Solovev, A.; Hansen, J. N.; Ege, M.; Friedrich, B. M.; Jurisch-Yaksi, N.

10.1101/2021.11.23.469646 — cell biology — Posted on 2022-02-06

2995 IL-34 deficiency impairs FOXP3+ Treg function and increases susceptibility to autoimmunity

Freuchet, A.; Salama, A.; Bézie, S.; Tesson, L.; Rémy, S.; Humeau, R.; Règue, H.; Flippe, L.; Peterson, P.; Vimond, N.; Usal, C.; Ménoret, S.; Heslan, J.-M.; Duteille, F.; Blanchard, F.; Giral, M.; Colonna, M.; Anegon, I.; Guillonneau, C.

10.1101/2022.02.04.479184 — immunology — Posted on 2022-02-06

2996 A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

Boehm, A. C.; Friedrich, A. B.; Hunt, S.; Bandow, P.; Siju, K. P.; De Backer, J.-F.; Claussen, J.; Link, M.-H.; Hofmann, T. F.; Dawid, C.; Grunwald Kadow, I. C.

10.1101/2021.07.24.453623 — neuroscience — Posted on 2022-02-06

2997 Constructing Causal Cytokine Networks for Autoimmune and Inflammatory Diseases Target Identification

Chen, Y.

10.1101/2022.01.30.478394 — bioinformatics — Posted on 2022-02-06

2998 Insights in the complex DegU, DegS, Spo0A regulation system of Paenibacillus polymyxa by CRISPR-Cas9-based targeted point mutations

Meliawati, M.; May, T.; Eckerlin, J.; Heinrich, D.; Herold, A.; Schmid, J.

10.1101/2022.02.03.479077 — molecular biology — Posted on 2022-02-06

2999 Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum

Forrester, S.; Goundry, A. L.; Dias, B. T.; Leal-Calvo, T.; Moraes, M. O.; Kaye, P.; Mottram, J.; Lima, A. P. C. A.

10.1101/2022.02.04.479211 — microbiology — Posted on 2022-02-06

3000 Chronic Alcohol Consumption Alters Home-Cage Behaviors and Responses to Ethologically Relevant Predator Tasks in Mice

Neira, S.; Hassanein, L.; Stanhope, C.; Buccini, M.; D'Ambrosio, S.; Flanigan, M.; Haun, H.; Boyt, K.; Bains, J. S.; kash, t.

10.1101/2022.02.04.479122 — neuroscience — Posted on 2022-02-06

3001 Climate change and chill accumulation: implications for tree fruit production in cold-winter regions

Noorazar, H.; Kalcsits, L.; Jones, V.; Jones, M.; Rajagopalan, K.

10.1101/2020.08.26.268979 — plant biology — Posted on 2022-02-06

3002 GSK2556286 is a novel antitubercular drug candidate effective in vivo with the potential to shorten tuberculosis treatment

Nuermberger, E.; Martinez, M. S.; Sanz, O.; Urones, B.; Esquivias, J.; Soni, H.; Tasneen, R.; Tyagi, S.; Li, S.-Y.; Converse, P. J.; Boshoff, H. I.; Robertson, G. T.; Besra, G.; Abrahams, K. A.; Upton, A.; Mdluli, K.; Boyle, G. W.; Turner, S.; Fotouhi, N.; Cammack, N. C.; Siles, J. M.; Alonso, M.; Excribano, J.; Lelievre, J.; Perez-Herran, E. M.; Bates, R. H.; Maher-Edwards, G. X.; Barros-Aguirre, D.; Ballell, L.; Jimenez, E. N.

10.1101/2022.02.04.479214 — pharmacology and toxicology — Posted on 2022-02-06

3003 Ubiquitous mRNA decay fragments in E. coli redefine the functional transcriptome

Herzel, L.; Stanley, J. A.; Yao, C.-C.; LI, G.-W.

10.1101/2021.11.18.469045 — molecular biology — Posted on 2022-02-06

3004 Single cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

Kirkwood, P. M.; Gibson, D. A.; Shaw, I.; Dobie, R.; Kelepouri, O.; Henderson, N. C.; Saunders, P. T.

10.1101/2021.12.20.473495 — physiology — Posted on 2022-02-06

3005 Generalized Hypergeometric Distributions Generated by Birth-Death Process in Bioinformatics

Kuznetsov, V. A.; Grageda, A.; Farbod, D.

10.1101/2022.02.02.478865 — bioinformatics — Posted on 2022-02-05

3006 A year in the life of the Eastern Mediterranean:Monthly dynamics of phytoplankton and bacterioplankton in an ultra-oligotrophic sea

Reich, T.; Ben-Ezra, T.; Belkin, N.; Tsemel, A.; Aharonovich, D.; Roth-Rosenberg, D.; Givati, S.; Bialik, O.; Herut, B.; Berman-Frank, I.; Frada, M.; Krom, M. D.; Lahahn, Y.; Rahav, E.; Sher, D.

10.1101/2021.03.24.436734 — microbiology — Posted on 2022-02-06

3007 Extracellular Vesicles Deliver Mitochondria and HSP27 Protein to Protect the Blood-Brain Barrier

Dave, K.; Stolz, D. B.; Reynolds, M. J.; Babidhan, R.; Dobbins, D. X.; Yankello, H.; Reddy, R.; Bae, Y.; Shiva, S.; Soundara Manickam, D.

10.1101/2021.10.29.466491 — bioengineering — Posted on 2022-02-05

3008 ACME: an Affinity-based Cas9 Mediated Enrichment method for targeted nanopore sequencing

Iyer, S. V.; Kramer, M.; Goodwin, S.; McCombie, W. R.

10.1101/2022.02.03.478550 — genomics — Posted on 2022-02-05

3009 Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary Dysplasia

Gao, F.; Li, C.; Smith, S.; Peinado, N.; Kohbodi, G.; Tran, E.; Loh, E.; Li, W.; Borok, Z.; Minoo, P.

10.1101/2022.01.24.477613 — developmental biology — Posted on 2022-02-05

3010 Unsupervised functional neurocartography of the Aplysia buccal ganglion

Costa, R. M.; Dharmaraj, V. A.; Homma, R.; Neveu, C. L.; Kristan, W. B.; Byrne, J. H.

10.1101/2021.12.20.473553 — neuroscience — Posted on 2022-02-05

3011 Pharmacogenetic and whole-brain activity analyses uncover integration of distinct molecular and circuit programs that drive learning

Nelson, J. C.; Shoenhard, H. M.; Granato, M.

10.1101/2022.02.05.479242 — neuroscience — Posted on 2022-02-05

3012 A cell type-specific multiomics uncovers a guard cell-specific RAF15-SnRK2.6/OST1 kinase cascade

Wang, H.; Wang, Y.; Li, R.; Ren, W.; Sang, T.; Zhao, B.; Wang, X.; Zhang, X.; Dai, S.; Hsu, C.-C.; Song, C.-P.; Wang, P.

10.1101/2021.07.06.451220 — plant biology — Posted on 2022-02-05

3013 Cryo-EM structure of the octameric pore of Clostridium perfringens β-toxin

Bruggisser, J.; Iacovache, I.; Musson, S. C.; Degiacomi, M. T.; Posthaus, H.; Zuber, B.

10.1101/2021.11.23.469684 — biophysics — Posted on 2022-02-05

3014 Monotreme-specific conserved proteins derived from retroviral reverse transcriptase

Kitao, K.; Miyazawa, T.; Nakagawa, S.

10.1101/2022.02.03.479050 — genomics — Posted on 2022-02-05

3015 The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization

Molina Pelayo, C.; Olguin, P.; Mlodzik, M.; Glavic, A.

10.1101/2022.02.05.479255 — cell biology — Posted on 2022-02-05

3016 Multiple mechanisms mediate the suppression of motion vision during escape maneuvers in flying Drosophila.

Fischer, P. J.; Schnell, B.

10.1101/2022.02.03.478949 — neuroscience — Posted on 2022-02-05

3017 Reward contingency gates selective cholinergic suppression of amygdala neurons

Kimchi, E. Y.; Burgos-Robles, A.; Matthews, G. A.; Chakoma, T.; Patarino, M.; Weddington, J. C.; Siciliano, C. A.; Yang, W.; Foutch, S.; Simons, R.; Fong, M.-f.; jing, m.; Li, Y.; Polley, D. B.; Tye, K. M.

10.1101/2022.02.04.479188 — neuroscience — Posted on 2022-02-05

3018 Developmental emergence of sleep rhythms enables long-term memory capabilities in Drosophila

Poe, A. R.; Zhu, L.; McClanahan, P. D.; Szuperak, M.; Anafi, R. C.; Cavanaugh, D. J.; Thum, A. S.; Kayser, M. S.

10.1101/2022.02.03.479025 — neuroscience — Posted on 2022-02-05

3019 The Ca2+-gated Cl- channel TMEM16A amplifies capillary pericyte contraction reducing cerebral blood flow after ischemia

Korte, N.; Ilkan, Z.; Pearson, C.; Pfeiffer, T.; Singhal, P.; Rock, J.; Sethi, H.; Gill, D.; Attwell, D.; Tammaro, P.

10.1101/2022.02.03.479031 — physiology — Posted on 2022-02-05

3020 Interactions between genes altered during cardiotoxicity and neurotoxicity in zebrafish revealed using induced network modules analysis

Kagoo, A. R.; Sharma, A.; Bhargava, A.

10.1101/2022.02.03.478934 — pharmacology and toxicology — Posted on 2022-02-05

3021 High rates of spontaneous chromosomal duplications are compensated by translational regulation in a photosynthetic unicellular eukaryote

Krasovec, M.; Merret, R.; Sanchez, F.; Sanchez-Brosseau, S.; Piganeau, G.

10.1101/2022.02.03.478961 — evolutionary biology — Posted on 2022-02-05

3022 Laboratory and field trials reveal the potential of a gel formulation of entomopathogenic nematodes as biocontrol against the fall armyworm (Spodoptera frugiperda)

Fallet, P.; Bazagwira, D.; Guenat, J.; Bustos-Segura, C.; Karangwa, P.; Mukundwa, I. P.; Kajuga, J.; Degen, T.; Toepfer, S.; Turlings, T. C. J.

10.1101/2022.02.03.479057 — ecology — Posted on 2022-02-05

3023 Physiological causes and biogeographic consequences of thermal optima in the hypoxia tolerance of marine ectotherms

Endress, M.-G. A.; Boag, T. H.; Burford, B. P.; Penn, J. L.; Sperling, E. A.; Deutsch, C. A.

10.1101/2022.02.03.478967 — ecology — Posted on 2022-02-05

3024 Priority effects determine how dispersal affects biodiversity in seasonal metacommunities

Zou, H.-X.; Rudolf, V. H. W.

10.1101/2022.02.03.479022 — ecology — Posted on 2022-02-05

3025 Regulation of mannitol metabolism in Enterococcus faecalis and association with parEF0409 toxin-antitoxin locus function.

Anbalagan, S.; Sadlon, J. P.; Weaver, K. E.

10.1101/2022.02.04.479212 — microbiology — Posted on 2022-02-05

3026 SPATIAL ORGANIZATION OF NEURON-ASTROCYTE INTERACTIONS IN THE SOMATOSENSORY CORTEX

Baraibar, A. M.; Belisle, L.; Marsicano, G.; Matute, C.; Mato, S.; Araque, A.; Kofuji, P.

10.1101/2022.02.03.479046 — neuroscience — Posted on 2022-02-05

3027 A heterogeneous drug tolerant persister state in BRAF-mutant melanoma is characterized by ion channel dysregulation and susceptibility to ferroptosis

Hayford, C. E.; Stauffer, P. E.; Baleami, B.; Paudel, B. B.; Tyson, D. R.; Al'Khafaji, A.; Johnson, K. E.; Harris, L. A.; Brock, A.; Quaranta, V.

10.1101/2022.02.03.479045 — systems biology — Posted on 2022-02-05

3028 Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

Mahauad-Fernandez, W. D.; Yang, Y. C.; Lai, I.; Park, J.; Yao, L.; Evans, J. W.; Burnett, G. L.; Gill, A.; Smith, J. A. M.; Singh, M.; Felsher, D. W.

10.1101/2022.02.04.478208 — cancer biology — Posted on 2022-02-05

3029 An expanded classification of active, inactive, and druggable RAS conformations

Parker, M. I.; Meyer, J. E.; Golemis, E. A.; Dunbrack, R. L.

10.1101/2022.02.02.478568 — bioinformatics — Posted on 2022-02-05

3030 Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA reveals novel spatial biology

Zhang, W.; Li, I.; Reticker-Flynn, N. E.; Good, Z.; Chang, S.; Samusik, N.; Saumyaa, S.; Li, Y.; Zhou, X.; Liang, R.; Kong, C. S.; Le, Q.-T.; Gentles, A. J.; Sunwoo, J. B.; Nolan, G. P.; Engleman, E. G.; Plevritis, S. K.

10.1101/2022.02.02.478888 — bioinformatics — Posted on 2022-02-05

3031 High-performance Flexible Microelectrode Array with PEDOT:PSS Coated 3D Micro-cones for Electromyographic Recording

Lu, J.; Zia, M.; Williams, M. J.; Jacob, A. L.; Chung, B.; Sober, S. J.; Bakir, M. S.

10.1101/2022.02.03.479004 — bioengineering — Posted on 2022-02-05

3032 Curvelet Transform-based Sparsity Promoting Algorithm for Fast Ultrasound Localization Microscopy

You, Q.; Trzasko, J.; Lowerison, M.; Chen, X.; Dong, Z.; Vaithiyalingam Chandra Sekaran, N.; Llano, D. A.; Chen, S.; Song, P.

10.1101/2022.02.02.478910 — bioengineering — Posted on 2022-02-05

3033 Genomic prediction with whole-genome sequence data in intensely selected pig lines

Ros-Freixedes, R.; Johnsson, M.; Whalen, A.; Chen, C.-Y.; Valente, B. D.; Herring, W. O.; Gorjanc, G.; Hickey, J. M.

10.1101/2022.02.02.478838 — genomics — Posted on 2022-02-05

Mesas, A.; Castaneda, L. E.

10.1101/2022.02.03.479001 — evolutionary biology — Posted on 2022-02-05

3035 Quantifying the Adaptive Potential of a Nascent Bacterial Community

Ascensao, J. A.; Wetmore, K. M.; Good, B. H.; Arkin, A. P.; Hallatschek, O.

10.1101/2022.02.03.475969 — evolutionary biology — Posted on 2022-02-05

3036 Evidence for evolutionary adaptation of mixotrophic nanoflagellates to warmer temperatures

Lepori-Bui, M.; Paight, C.; Eberhard, E.; Mertz, C. M.; Moeller, H. V.

10.1101/2022.02.03.479051 — ecology — Posted on 2022-02-05

3037 Comparative small RNA and degradome sequencing provide new insights into antagonistic interactions in the biocontrol fungus Clonostachys rosea

Piombo, E.; Vetukuri, R. R.; Sundararajan, P.; Kushwaha, S. K.; Funck Jensen, D.; Karlsson, M.; Dubey, M.

10.1101/2022.02.04.479213 — microbiology — Posted on 2022-02-05

3038 Interaction of an α-synuclein epitope with HLA-DRB1*15:01 initiates early enteric features of Parkinson's disease in humanized mice

Garretti, F.; Monahan, C.; Sloan, N.; Shariar, S.; Kim, S. W.; Sette, A.; Cutforth, T.; Kanter, E.; Sulzer, D.; Agalliu, D.

10.1101/2022.02.03.479014 — neuroscience — Posted on 2022-02-05

3039 Enhanced excitability of the hippocampal CA2 region and its contribution to seizure generation in a mouse model of temporal lobe epilepsy

Whitebirch, A. C.; LaFrancois, J. J.; Jain, S.; Leary, P.; Santoro, B.; Siegelbaum, S. A.; Scharfman, H. E.

10.1101/2022.02.02.478736 — neuroscience — Posted on 2022-02-05

3040 Whole-Brain Map of Top-down afferent Inputs to Nucleus Accumbens of the Mouse

XU, T.; Wu, J.; Li, Z.; Chen, Z.

10.1101/2022.02.02.478577 — neuroscience — Posted on 2022-02-05

3041 A scalable pipeline for SARS-CoV-2 replicon construction based on de-novo synthesis

Berkyurek, A. C.; Lee, E.; Weissbrod, O.; Rasnic, R.; Falciatori, I.; Chen, S.; Erlich, Y.

10.1101/2022.02.05.478644 — synthetic biology — Posted on 2022-02-05

3042 Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade

Mehta, A.; Rucevic, M.; Sprecher, E.; Parikh, M.; Chem, J.; Frederick, D. T.; Woods, E.; Bi, L.; Lieb, D.; Hultin-Rosenberg, L.; Guess, J.; Park, R. J.; Schneider, A.; Michaud, W.; Miao, B.; Kasumova, G.; Kim, M. S.; Bai, X.; Jenkins, R. W.; Klempner, S. J.; Gonye, A. L.; Yizhak, K.; Sade-Feldman, M.; Liu, D.; Sullivan, R. J.; Flaherty, K. T.; Hacohen, N.; Boland, G. M.

10.1101/2022.02.02.478819 — cancer biology — Posted on 2022-02-05

3043 Profiling Unbinding Events to Identify Near-Native RNA-Ligand Poses

Liu, Y.; Frank, A. T.

10.1101/2022.02.05.479229 — biophysics — Posted on 2022-02-05

3044 A scalable and unbiased discordance metric with H+

Dyjack, N.; Baker, D. N.; Braverman, V.; Langmead, B.; Hicks, S. C.

10.1101/2022.02.03.479015 — bioinformatics — Posted on 2022-02-05

3045 Rtt105 configurationally staples RPA and blocks facilitated exchange and interactions with RPA-interacting proteins

Kuppa, S.; Deveryshetty, J.; Chadda, R.; Mattice, J.; Pokhrel, N.; Kaushik, V.; Patterson, A.; Dhingra, N.; Pangeni, S.; Sadauskas, M. K.; Shiekh, S.; Balci, H.; Ha, T.; Zhao, X.; Bothner, B.; Antony, E.

10.1101/2022.02.05.479199 — biochemistry — Posted on 2022-02-05

3046 Monotreme-specific conserved proteins derived from retroviral reverse transcriptase

Kitao, K.; Miyazawa, T.; Nakagawa, S.

10.1101/2022.02.03.479050 — genomics — Posted on 2022-02-05

3047 Investigations into the emergent properties of gene-to-phenotype networks across cycles of selection: A case study of shoot branching in plants

Powell, O.; Barbier, F. F.; Voss-Fels, K. P.; Beveridge, C. A.; Cooper, M.

10.1101/2022.02.03.479064 — genetics — Posted on 2022-02-05

3048 Coexistence between similar invaders: The case of two cosmopolitan exotic insects

Arnold, M. B.; Back, M.; Crowell, M. D.; Farooq, N.; Ghimire, P.; Obarein, O. A.; Smart, K. E.; Taucher, T.; VanderJeugdt, E.; Perry, K. I.; Landis, D. A.; Bahlai, C.

10.1101/2022.02.03.479030 — ecology — Posted on 2022-02-05

3049 Progerin triggers a phenotypic switch in vascular smooth muscle cells that causes replication stress and an aging-associated secretory signature

Coll-Bonfill, N.; Mahajan, U.; Lin, C.-J.; Mecham, R. P.; Gonzalo, S.

10.1101/2022.02.05.479232 — cell biology — Posted on 2022-02-05

3050 DNA opening during transcription initiation by RNA polymerase II in atomic detail

Lapierre, J.; Hub, J. S.

10.1101/2022.02.05.479244 — biophysics — Posted on 2022-02-05

3051 Interferon receptor gene dosage determines multiple hallmarks of Down syndrome

Waugh, K. A.; Minter, R.; Baxter, J.; Chi, C.; Tuttle, K. D.; Eduthan, N. P.; Galbraith, M. D.; Kinning, K. T.; Andrysik, Z.; Araya, P.; Dougherty, H.; Dunn, L. N.; Ludwig, M.; Schade, K. A.; Tracy, D.; Smith, K. P.; Granrath, R. E.; Busquet, N.; Khanal, S.; Anderson, R. D.; Cox, L. L.; Estrada, B. E.; Rachubinski, A. L.; Lyford, H. R.; Britton, E. C.; Orlicky, D. J.; Matsuda, J. L.; Song, K.; Cox, T. C.; Sullivan, K. D.; Espinosa, J. M.

10.1101/2022.02.03.478982 — genetics — Posted on 2022-02-05

3052 A centromeric RNA-associated protein complex affects germ line development in Drosophila melanogaster.

Hoecker, S. L.; Su Akan, I.; Simon, A. M.; Yildirim, K.; Lohmann, I.; Erhardt, S.

10.1101/2022.02.05.479222 — cell biology — Posted on 2022-02-05

3053 All-optical imaging and patterned stimulation with a one-photon endoscope

Zhang, J.; Hughes, R. N.; Kim, N.; Fallon, I. P.; Bakhurin, K. I.; Kim, J.; Ulloa Severino, F. P.; Yin, H. H.

10.1101/2021.12.19.473349 — neuroscience — Posted on 2022-02-05

3054 Sensory Schwann cells are required for mechanical nociception and touch perception

Ojeda-Alonso, J.; Calvo-Enrique, L.; Paricio-Montesinos, R.; Kumar, R.; Dong-Zhang, M.; Poulet, J. F. A.; Ernfors, P.; Lewin, G. R.

10.1101/2022.02.04.477749 — neuroscience — Posted on 2022-02-05

3055 Dynamic gain decomposition reveals functional effects of dendrites, ion channels and input statistics in ultrafast population encoding

Zhang, C.; Revah, O.; Wolf, F.; Neef, A.

10.1101/2022.02.04.479104 — neuroscience — Posted on 2022-02-05

3056 Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment.

Jabba, S. V.; Erythropel, H. C.; Torres, D. G.; Delgado, L. A.; Woodrow, J. G.; Anastas, P. T.; Zimmerman, J. B.; Jordt, S. E.

10.1101/2021.06.09.446946 — pharmacology and toxicology — Posted on 2022-02-05

3057 Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

Zhang, L.; Li, L.; Wang, X.; Liu, H.; Zhang, Y.; Xie, T.; Zhang, H.; Li, X.; Peng, T.; Sun, X.; Dai, J.; Liu, J.; Wu, W.; Ye, M.; Tan, W.

10.1101/2021.08.05.455211 — biochemistry — Posted on 2022-02-05

3058 Ear pinnae in a neotropical katydid (Orthoptera: Tettigoniidae) function as ultrasound guides for bat detection

Pulver, C.; Celiker, E.; Woodrow, C.; Geipel, I.; Soulsbury, C.; Cullen, D.; Rogers, S. M.; Veitch, D.; Montealegre-Z, F.

10.1101/2021.09.01.458595 — biophysics — Posted on 2022-02-05

3059 Bidirectional, unlike unidirectional transport, allows transporting axonal cargos against their concentration gradient

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2021.01.27.428531 — biophysics — Posted on 2022-02-05

3060 Can Hypnotic Susceptibility be Explained by Bifactor Models? Structural Equation Modeling of the Harvard Group Scale of Hypnotic Susceptibility - Form A

Zahedi, A.; Sommer, W.

10.1101/2021.04.29.441926 — neuroscience — Posted on 2022-02-05

3061 Phenotypic Pliancy and the Breakdown of Epigenetic Polycomb Mechanisms

Lambros, L.; Sella, Y.; Bergman, A.

10.1101/2022.01.18.476783 — systems biology — Posted on 2022-02-05

3062 Endothelial beta-arrestins Regulate Mechanotransduction by the Type II Bone Morphogenetic Protein Receptor in Primary Cilia

Park, S.; Ma, Z.; Zarkada, G.; Papangeli, I.; Paluri, S.; Nazo, N.; Xiong, X.; Rivera-Molina, F.; Toomre, D.; Rajagopal, S.; Chun, H. J.

10.1101/2022.02.04.479175 — molecular biology — Posted on 2022-02-05

3063 Frequency of a nucleotide overhang at the 5' end of hemorrhagic fever mammarenavirus genomes in public sequence data

Neriya, Y.; Kojima, S.; Kishimoto, M.; Sakiyama, A.; Iketani, T.; Watanabe, T.; Abe, Y.; Shimoda, H.; Nakagawa, K.; Koma, T.; Matsumoto, Y.

10.1101/2022.02.04.479072 — microbiology — Posted on 2022-02-05

3064 IgD+ Age-Associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

Kugler-Umana, O. A.; Zhang, W.; Kuang, Y.; Liang, J.; Castonguay, C.; Tonkonogy, S. L.; Marshak-Rothstein, A.; Devarajan, P.; Swain, S. L.

10.1101/2022.02.04.479159 — immunology — Posted on 2022-02-05

3065 Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury

Ozanturk, A. N.; Sahu, S. K.; Kulkarni, D. H.; Ma, L.; Barve, R. A.; McPhatter, J.; Garnica, L.; Dannull, L.; Wu, X.; Brody, S. L.; Atkinson, J. P.; Kulkarni, H. S.

10.1101/2022.02.03.478963 — immunology — Posted on 2022-02-05

3066 Oligomerization processes limit photoactivation and recovery of the Orange Carotenoid Protein.

Andreeva, E. A.; Nizinski, S.; Wilson, A.; Levantino, M.; De Zitter, E.; Munro, R.; Muzzopappa, F.; Thureau, A.; Zala, N.; Burdzinski, G.; Sliwa, M.; Kirilovsky, D.; Schiro, G.; Colletier, J.-P.

10.1101/2022.02.04.479168 — biophysics — Posted on 2022-02-05

3067 Understanding the Separation of Timescales in Rhodococcus erythropolis Proteasome Core Particle Assembly

Itagi, P.; Kante, A.; Lagunes, L.; Deeds, E. J.

10.1101/2022.02.04.479176 — biophysics — Posted on 2022-02-05

3068 Single-Objective Evanescent Scattering Microscopy for Imaging Single Proteins and Binding Kinetics

ZHANG, P.; Wang, R.; Wan, Z.; Zhou, X.; Ma, G.; Kolay, J.; Jiang, J.; Wang, S.

10.1101/2022.02.04.479201 — biophysics — Posted on 2022-02-05

3069 A novel 5' DNA binding site in RFC facilitates PCNA loading for gap DNA repair

Zhang, F.; Georgescue, R.; Yao, N. Y.; Li, H.; O'Donnell, M. E.

10.1101/2022.02.04.479194 — biochemistry — Posted on 2022-02-05

3070 Human XIST RNA acts early to condense architecture which facilitates A-repeat density-dependent initiation of gene silencing

Valledor, M.; Byron, M.; Dumas, B.; Carone, D. M.; Hall, L. L.; Lawrence, J. B.

10.1101/2022.02.04.479153 — cell biology — Posted on 2022-02-05

3071 Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration

Ramirez-Pardo, I.; Villarejo-Zori, B.; Jimenez-Loygorri, J. I.; Sierra-Filardi, E.; Alonso-Gil, S.; Marino, G.; de la Villa, P.; Fitze, P. S.; Fuentes, J. M.; Garcia-Escudero, R.; Gomez-Sintes, R.; Boya, P.

10.1101/2022.02.04.476630 — cell biology — Posted on 2022-02-05

3072 Membrane remodeling due to mixture of multiple curvature proteins

Kumar, G.; Srivastava, A.

10.1101/2021.10.02.462266 — biophysics — Posted on 2022-02-04

3073 MERIT: controlling Monte-Carlo error rate in large-scale Monte-Carlo hypothesis testing

Li, Y.; Hu, Y.; Satten, G. A.

10.1101/2022.01.15.476485 — bioinformatics — Posted on 2022-02-04

3074 Target deconvolution using in vitro evolution in haploid human cells

Jado, J. C.; Dow, M.; Carolino, K.; Klie, A.; Fonseca, G.; Ideker, T.; Carter, H.; Winzeler, E.

10.1101/2020.03.17.982181 — genomics — Posted on 2022-02-04

3075 Gene drive escape from resistance depends on mechanism and ecology

Cook, F.; Bull, J. J.; Gomulkiewicz, R.

10.1101/2021.08.30.458221 — evolutionary biology — Posted on 2022-02-04

3076 Habitat Suitability Modeling and Ecological Forecasting of Northern Goshawk Nesting Habitat

Wright, M. E.; Jackson, J.; Tornberg, R.; Higa, E.; Clayton, A.; McCartney, S.; Ranglack, D. H.; Bickford, N.

10.1101/2022.02.04.479095 — ecology — Posted on 2022-02-04

3077 Monitoring conservation effectiveness in tropical forests: bushmeat offtake parameters vary more quickly compared to parameters related to the living wildlife community

Jacques, K. K.; Tagg, N.; Mbohli Khan, D.; Speelman, S.; Willie, J.

10.1101/2022.02.04.479098 — ecology — Posted on 2022-02-04

3078 Swine H1N1 influenza virus variants with enhanced polymerase activity and HA stability promote airborne transmission in ferrets

Hu, M.; Jones, J.; Banoth, B.; Ojha, C. R.; Crumpton, J. C.; Kercher, L.; Webster, R. G.; Webby, R. J.; Russell, C. J.

10.1101/2021.09.22.461336 — microbiology — Posted on 2022-02-04

3079 Novel Association of Lyme Disease, Age, and Atopic Dermatitis

Lee, B. T.; Galloway, S.; Strausz, S.; Hansen, P.; Torrez-Dulgeroff, L. B.; Blacker, G.; Yiu, Y. Y.; Mansfield, P.; FinnGen, ; Saleem, A.; Gars, E.; Sanders, E.; Weissman, I. L.; Ollila, H.; Tal, M. C.

10.1101/2022.01.27.476641 — immunology — Posted on 2022-02-04

3080 Transcription Factor Acj6 Controls Dendrite Targeting via CombinatorialCell-Surface Codes

Xie, Q.; Li, J.; Li, H.; Udeshi, N. D.; Svinkina, T.; Orlin, D.; Kohani, S.; Guajardo, R.; Mani, D. R.; Xu, C.; Li, T.; Han, S.; Wei, W.; Shuster, S. A.; Luginbuhl, D. J.; Quake, S. R.; Murthy, S.; Ting, A. Y.; Carr, S. A.; Luo, L.

10.1101/2021.11.03.467130 — neuroscience — Posted on 2022-02-04

3081 Training a spiking neuronal network model of visual-motor cortex to play a virtual racket-ball game using reinforcement learning

Anwar, H.; Caby, S.; Dura-Bernal, S.; D'Onofrio, D.; Hasegan, D.; Deible, M.; Grunblatt, S.; Chadderdon, G. L.; Kerr, C. C.; Lakatos, P.; Lytton, W. W.; Hazan, H.; Neymotin, S. A.

10.1101/2021.07.29.454361 — neuroscience — Posted on 2022-02-04

3082 Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

Blencowe, M.; Chen, X.; Zhao, Y.; Itoh, Y.; McQuillen, C.; Han, Y.; Shou, B.; McClusky, R.; Reue, K.; Arnold, A. P.; Yang, X.

10.1101/2021.07.18.451543 — systems biology — Posted on 2022-02-04

3083 Synthetic mammalian signaling circuits for robust cell population control

Ma, Y.; Budde, M. W.; Mayalu, M. N.; Zhu, J.; Lu, A. C.; Murray, R. M.; Elowitz, M. B.

10.1101/2020.09.02.278564 — synthetic biology — Posted on 2022-02-04

3084 Evaluation of Nutritional Potential and Effect of Processing on Improving Nutrient Content of Cassava (Mannihot esculenta crantz) Root and Leaves

Lambebo, T.; Deme, T.

10.1101/2022.02.04.479097 — scientific communication and education — Posted on 2022-02-04

3085 Membrane-catalyzed IAPP aggregation is dominated by secondary nucleation

Elenbaas, B. O. W.; Khemtemourian, L.; Killian, J. A.; Sinnige, T.

10.1101/2022.02.04.479144 — biophysics — Posted on 2022-02-04

3086 Enthalpic and Entropic Contributions to Interleaflet Coupling Drive Domain Registration and Anti-registration in Biological Membrane

Sharma, A.; Seal, A.; Iyer, S. S.; Srivastava, A.

10.1101/2021.09.29.462263 — biophysics — Posted on 2022-02-04

3087 Network Analysis Reveals Different Cellulose Degradation Strategies across Trichoderma harzianum Strains Associated with XYR1 and CRE1

Rosolen, R. R.; Aono, A. H.; Almeida, D. A.; Filho, J. A. F.; Horta, M. A. C.; de Souza, A. P.

10.1101/2020.05.02.074344 — bioinformatics — Posted on 2022-02-04

3088 Migrators Within Migrators: Exploring Transposable Element Dynamics in the Monarch Butterfly, Danaus plexippus

Baril, T. J.; Hayward, A.

10.1101/2021.09.28.462135 — genomics — Posted on 2022-02-04

3089 Mutations in coral soma and sperm imply lifelong stem cell renewal and cell lineage selection

Lopez-Nandam, E. H.; Albright, R.; Hanson, E. A.; Sheets, E. A.; Palumbi, S. R.

10.1101/2021.07.20.453148 — genetics — Posted on 2022-02-04

3090 Identification of enhancer-like elements defines regulatory networks active in planarian adult stem cells

Neiro, J.; Sridhar, D.; Dattani, A.; Aboobaker, A.

10.1101/2022.02.03.479047 — developmental biology — Posted on 2022-02-04

3091 Effect of compound Tinglizi Decoction on non-classical pathway of pyroptosis in rats with chronic obstructive pulmonary disease related pulmonary hypertension

Wang, Q.; Liu, M.; Liu, Y.; Bai, Z.

10.1101/2022.02.04.479096 — cell biology — Posted on 2022-02-04

3092 Express Arm Responses Appear Bilaterally on Upper-limb Muscles in An Arm Choice Reaching Task

Kearsley, S. L.; Cecala, A. L.; Kozak, R. A.; Corneil, B. D.

10.1101/2021.09.24.461726 — neuroscience — Posted on 2022-02-04

3093 Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

Gustafsson, T.; Galan, C.; Yu, T.; Upton, H.; Ferguson, L.; Kaymak, E.; Weng, Z.; Collins, K.; Rando, O.

10.1101/2022.02.04.479139 — genomics — Posted on 2022-02-04

3094 Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

Xu, J.; Kumar, S.; Hua, N.; Kou, Y.; Lei, X.; Aitchison, J.; Rout, M.; Alber, F.; Chen, L.

10.1101/2022.02.03.478915 — genomics — Posted on 2022-02-04

3095 Interactions between evolved pesticide resistance and pesticide exposure on immunity against pathogens

Birnbaum, S. S. L.; Schulz, N. K.; Tate, A. T.

10.1101/2022.02.04.479151 — evolutionary biology — Posted on 2022-02-04

3096 Single cell transcriptomic and spatial landscapes of the developing human pancreas

Olaniru, O. E.; Kadolsky, U.; Kannambath, S.; Vaikkinen, H.; Fung, K.; Dhami, P.; Persaud, S.

10.1101/2022.02.04.478971 — developmental biology — Posted on 2022-02-04

3097 Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD

Abenza, J. F.; Rossetti, L.; Mouelhi, M.; Burgues, J.; Andreu, I.; Kennedy, K.; Roca-Cusachs, P.; Marco, S.; Garcia-Ojalvo, J.; Trepat, X.

10.1101/2022.02.04.478830 — cell biology — Posted on 2022-02-04

3098 Air pollution induces Staphylococcus aureus USA300 respiratory tract colonisation mediated by specific bacterial genetic responses dependent on the global virulence gene regulators Agr and Sae

Purves, J.; Hussey, S. J. K.; Corscadden, L.; Purser, L.; Hall, A.; Misra, R.; Monks, P. S.; Ketley, J. M.; Andrew, P. W.; Morrissey, J. A.

10.1101/2022.02.04.479102 — microbiology — Posted on 2022-02-04

3099 Model-free prediction of microbiome compositions

Asher, E. E.; Bashan, A.

10.1101/2022.02.04.479107 — microbiology — Posted on 2022-02-04

3100 Testing the Efficacy of Transungual Drug Delivery System (Nail Lacquer) Containing Terbinafine Against Aspergillus brasiliensis for the Topical Treatment of Onychomycosis.

Rao, S. H.; Bhalekar, M. R.; Kelkar, S. H.; Godbole, S. S.; Kharche, R. A.

10.1101/2022.02.03.478980 — microbiology — Posted on 2022-02-04

3101 Arbovirus-vector protein interactomics identifies Loquacious as a co-factor for dengue virus replication in Aedes mosquitoes

Besson, B.; Lezcano, O. M.; Overheul, G. J.; Janssen, K.; Spruijt, C. G.; Vermeulen, M.; Qu, J.; Van Rij, R. P.

10.1101/2022.02.04.479089 — microbiology — Posted on 2022-02-04

3102 Inactivating Mast Cell Function Promotes Steady-State and Regenerative Hematopoiesis

Smith, J. N. P.; Campanelli, J.; Cordova, B.; Broncano, A.; Christo, K. F.; Markowitz, S. D.; Gerson, S. L.; Desai, A. B.

10.1101/2022.02.03.479012 — immunology — Posted on 2022-02-04

3103 Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes

Skovsø, S.; Overby, P.; Memar-Zadeh, J.; Lee, J.; Shanina, I.; Sidarala, V.; Levi-D Ancona, E.; Zhu, J.; Soleimanpour, S. A.; Horwitz, M.; Johnson, J. D.

10.1101/2022.02.03.479027 — immunology — Posted on 2022-02-04

3104 Science in motion: A qualitative analysis of journalists' use and perception of preprints

Fleerackers, A.; Moorhead, L.; Maggio, L. A.; Fagan, K.; Alperin, J. P.

10.1101/2022.02.03.479041 — scientific communication and education — Posted on 2022-02-04

3105 Genome-wide identification, characterization, and comparative analysis of NLR resistance genes in Coffea spp.

Santos, M. d. L.; de Resende, M. l. V.; Alves, G. S. C.; Huguet-Tapia, J. C.; de Resende, M. F. R.; Brawner, J. T.

10.1101/2022.02.03.478062 — plant biology — Posted on 2022-02-04

3106 Minimal RNA replicons for targeted gene silencing based on an asymptomatic viroid

Marquez-Molins, J.; Urrutia-Perez, M.; Hernandez-Azurdia, A. G.; Pallas, V.; Gomez, G.

10.1101/2022.02.04.479109 — plant biology — Posted on 2022-02-04

3107 KMT2C deficiency promotes APOBEC mutagenesis and genomic instability in multiple cancers

Hu, X.; Biswas, A.; De, S.

10.1101/2022.02.04.478993 — cancer biology — Posted on 2022-02-04

3108 AAA+ protease-adaptor structures reveal altered conformations and ring specialization

Kim, S.; Fei, X.; Sauer, R. T.; Baker, T. A.

10.1101/2022.02.04.479121 — biophysics — Posted on 2022-02-04

3109 Antibody affinity and concentration of convalescent sera provide context for reduced SARS-CoV-2 Omicron spike affinity of therapeutic antibodies

10.1101/2022.02.03.478946 — biochemistry — Posted on 2022-02-04

3110 Analysis of altered pre-mRNA splicing patterns caused by a mutation in the RNA binding protein hnRNPA1 linked to amyotrophic lateral sclerosis

Rio, D. C.; Lee, Y. J.

10.1101/2022.02.03.479052 — biochemistry — Posted on 2022-02-04

3111 Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo

Tuli, F.; Kane, P. M.

10.1101/2022.02.04.479146 — biochemistry — Posted on 2022-02-04

3112 ACME: an Affinity-based Cas9 Mediated Enrichment method for targeted nanopore sequencing

Iyer, S. V.; Kramer, M.; Goodwin, S.; McCombie, W. R.

10.1101/2022.02.03.478550 — genomics — Posted on 2022-02-04

3113 An Inducible Cre Mouse with Preferential Activity in Vascular Smooth Muscle Evades a Previously Lethal Intestinal Phenotype

Warthi, G. D.; Faulkner, J. L.; Doja, J.; Ghanam, A. R.; Gao, P.; Yang, A. C.; Slivano, O. J.; Barris, C. T.; Kress, T. C.; Zawieja, S. D.; Griffin, S. H.; Xie, X.; Ashworth, A.; Christie, C. K.; Bryant, W. B.; Kumar, A.; Davis, M. J.; Long, X.; Gan, L.; Belin de Chantemele, E. J.; Lyu, Q.; Miano, J. M.

10.1101/2022.02.03.479061 — genetics — Posted on 2022-02-04

3114 ZNF598 responds to mitochondrial stress to abort stalled translation on mitochondrial outer membrane and maintain tissue homeostasis

Lu, B.; Geng, J.; Li, Y.; Ohja, R.; Wu, Z.; Li, S.

10.1101/2022.02.04.479092 — cell biology — Posted on 2022-02-04

3115 During replicative aging, changes in DNA double-strand break repair correlate with an increased rate of mutation.

Mojumdar, A.; Mair, N.; Adam, N.; Cobb, J. A.

10.1101/2022.02.04.479125 — molecular biology — Posted on 2022-02-04

3116 Viviparity is sufficient for the evolution of genomic imprinting

Montgomery, S. A.; Hisanaga, T.; Wang, N.; Axelsson, E.; Akimcheva, S.; Sramek, M.; Liu, C.; Berger, F.

10.1101/2022.02.04.477531 — molecular biology — Posted on 2022-02-04

3117 Candidate undecaprenyl phosphate translocases enable conditional microbial fitness and pathogenesis

Sit, B.; Srisuknimit, V.; Hullahalli, K.; Bueno, E.; Cava, F.; Waldor, M. K.

10.1101/2022.02.04.479082 — microbiology — Posted on 2022-02-04

3118 Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Krischuns, T.; Isel, C.; Drncova, P.; Lukarska, M.; Pflug, A.; Paisant, S.; Navratil, V.; Cusack, S.; Naffakh, N.

10.1101/2022.02.04.479088 — microbiology — Posted on 2022-02-04

3119 VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

10.1101/2022.02.03.479007 — microbiology — Posted on 2022-02-04

3120 Deceiving The Big Eaters: Salmonella Typhimurium SopB subverts host cell Xenophagy through the Akt-TFEB axis in macrophages

Chatterjee, R.; Chaudhuri, D.; Gangi Setty, S. R.; Chakravortty, D.

10.1101/2022.02.03.479023 — microbiology — Posted on 2022-02-04

3121 Re-sensitising XDR biofilms using a combination of bacteriophage cocktails and colistin: a natural approach

10.1101/2022.02.04.479063 — microbiology — Posted on 2022-02-04

3122 In vitro phenotypic and transcriptomic variation in Neisseria musculi morphotypes correlate with colonization variability and persistence in vivo

Thapa, E.; Lauderback, L.; Simmons, C.; Holzschu, D. L.; D'Mello, A.; Ma, M.; So, M.; Tettelin, H.; Weyand, N. J.

10.1101/2022.02.03.479073 — microbiology — Posted on 2022-02-04

3123 Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells

Sur, S.; steele, r.; Isbell, S.; Ray, R.; Ray, R. B.

10.1101/2022.02.03.479081 — immunology — Posted on 2022-02-04

3124 In vitro effect of a non-immunosuppressive FKBP ligand, FK1706, on SARS-CoV-2 replication in combination with antivirals

Fitzsimmons, W.; Chen, C.; Mendenhall, M.; Hartman, T. L.

10.1101/2022.02.03.479080 — pharmacology and toxicology — Posted on 2022-02-04

3125 New Functions Identified for HIV gp120 with the New ProtSub Sequence Matching

Litterer, B.; Shome, S.; Jia, K.; Jernigan, R. L.

10.1101/2022.02.01.478707 — bioinformatics — Posted on 2022-02-04

3126 patcHwork: A user-friendly pH sensitivity analysis web server for protein sequences and structures

Schmitz, M.; Schultze, A.; Vanags, R.; Voigt, K.; Di Ventura, B.; Oeztuerk, M. A.

10.1101/2022.02.02.478804 — bioinformatics — Posted on 2022-02-04

3127 Federated analysis in COINSTAC reveals functional network connectivity and spectral links to smoking and alcohol consumption in nearly 2,000 adolescent brains

Gazula, H.; Rootes-Murdy, K.; Holla, B.; Basodi, S.; Zhang, Z.; Verner, E.; Kelly, R.; Murthy, P.; Chakrabarti, A.; Basu, D.; Bhagyalakshmi, S.; Lenin, R.; Lourembam, R.; Kalyanram, K.; Kartik, K.; Kalyanaraman, K.; Ghattu, K.; Kuriyan, R.; Kurpad, S. S.; Barker, G.; Bharath, R. D.; Desrivieres, S.; Purushottam, M.; Orfanos, D. P.; Sharma, E.; Hickman, M.; Toledano, M.; Vaidya, N.; Banaschewski, T.; Bokde, A. L. W.; Flor, H.; Grigis, A.; Garavan, H.; Gowland, P.; Heinz, A.; Bruhl, R.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; Nees, F.; Paus, T.; Poustka, L.; Frohner, J. H.; Robinson, L

10.1101/2022.02.02.478847 — bioinformatics — Posted on 2022-02-04

3128 IDSL.UFA assigns high confidence molecular formula annotations for untargeted LC/HRMS datasets in metabolomics and exposomics

Fakouri-Baygi, S.; Banerjee, S.; Chakraborty, P.; Kumar, Y.; Barupal, D. K.

10.1101/2022.02.02.478834 — bioinformatics — Posted on 2022-02-04

3129 Deep Learning-based Microbubble Localization for Ultrasound Localization Microscopy

Chen, X.; Lowerison, M.; Dong, Z.; Han, A.; Song, P.

10.1101/2022.02.02.478911 — bioengineering — Posted on 2022-02-04

3130 Trait divergence and trade-offs among Brassicaceae species differing in elevational distribution

Maccagni, A.; Willi, Y.

10.1101/2022.02.02.478839 — ecology — Posted on 2022-02-04

3131 How exposure to land use impacts and climate change may prune the tetrapod tree of life

Beaumont, L. J.; Nipperess, D. A.; Wilson, P. D.; Baumgartner, J. B.; Esperon-Rodriguez, M.

10.1101/2022.02.01.478740 — ecology — Posted on 2022-02-04

3132 Emergence of time persistence in an interpretable data-driven neural network model

Wolf, S.; Le Goc, G.; Cocco, S.; Debregeas, G.; Monasson, R.

10.1101/2022.02.02.478841 — neuroscience — Posted on 2022-02-04

3133 Corticospinal excitability is influenced by the recent history of electrical digital stimulation: implications for the relative magnitude of short-latency afferent inhibition

Bonnesen, M. T.; Fuglsang, S. A.; Siebner, H. R.; Christiansen, L.

10.1101/2022.02.02.478861 — neuroscience — Posted on 2022-02-04

3134 Joint coding of visual input and eye/head position in V1 of freely moving mice

Parker, P. R. L.; Abe, E. T. T.; Leonard, E. S. P.; Martins, D. M.; Niell, C. M.

10.1101/2022.02.01.478733 — neuroscience — Posted on 2022-02-04

3135 Tandem Walk in Simulated Martian Gravity and Visual Environment

Rosenberg, M. J.; Koslovsky, M.; Noyes, M.; Reschke, M. F.; Clement, G.

10.1101/2022.02.01.478711 — neuroscience — Posted on 2022-02-04

3136 Information theory rules out the reflex-chain model of C. elegans locomotion

Kato, S.; Webb, J.

10.1101/2022.02.01.478702 — neuroscience — Posted on 2022-02-04

3137 Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression

LI, Q.; Takeuchi, Y.; Wang, J.; Barcsai, L.; Pedraza, L. K.; Kozák, G.; Nakai, S.; Kato, S.; Kobayashi, K.; Ohsawa, M.; Lorincz, M. L.; Devinsky, O.; Buzsaki, G.; Berényi, A.

10.1101/2022.02.01.478683 — neuroscience — Posted on 2022-02-04

3138 Why Are Alzheimer's Disease Patients Unaware of their Memory Deficits?

Razafimahatratra, S.; Guieysse, T.; Lejeune, F. X.; Houot, M.; Medani, T.; Dreyfus, G.; Klarsfeld, A.; Villain, N.; Raposo Pereira, F.; La Corte, V.; George, N.; Pantazis, D.; Andrade, K.

10.1101/2022.02.01.478754 — neuroscience — Posted on 2022-02-04

3139 Taurine or N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

Garcia-Serrano, A. M.; Vieira, J. P. P.; Fleischhart, V.; Duarte, J. M. N.

10.1101/2022.02.02.478774 — neuroscience — Posted on 2022-02-04

3140 Top-down control of the left visual field bias in cued visual spatial attention

Meyyappan, S.; Rajan, A.; Mangun, G. R.; Ding, M.

10.1101/2022.02.02.478855 — neuroscience — Posted on 2022-02-04

3141 Test-retest reproducibility of human brain multi-slice 1H FID-MRSI data at 9.4 T after optimization of lipid regularization, macromolecular model and spline baseline stiffness

Ziegs, T.; Wright, A. M.; Henning, A.

10.1101/2022.02.02.478678 — neuroscience — Posted on 2022-02-04

3142 The metric backbone preserves community structure and is a primary transmission subgraph in contact networks

Brattig Correia, R.; Barrat, A.; Rocha, L. M.

10.1101/2022.02.02.478784 — systems biology — Posted on 2022-02-04

3143 An approachable, flexible, and practical machine learning workshop for biologists

Magnano, C. S.; Mu, F.; Russ, R. S.; Cvetkovic, M.; Treu, D.; Gitter, A.

10.1101/2022.02.03.479008 — scientific communication and education — Posted on 2022-02-04

3144 IDSL.CCDB: a database for exploring inter-chemical correlations in metabolomics and exposomics datasets

Barupal, D. K.; Mahajan, P.; Fakouri-Baygi, S.; Wright, R. O.; Arora, M.; Teitelbaum, S. L.

10.1101/2022.02.01.478739 — bioinformatics — Posted on 2022-02-04

3145 Generalized Hypergeometric Distributions Generated by Birth-Death Process in Bioinformatics

Farbod, D.; Kuznetsov, V. A.; Grageda, A.

10.1101/2022.02.02.478865 — bioinformatics — Posted on 2022-02-04

3146 Scalable microbial strain inference in metagenomic data using StrainFacts

Smith, B. J.; Li, X.; Shi, Z. J.; Abate, A.; Pollard, K. S.

10.1101/2022.02.01.478746 — bioinformatics — Posted on 2022-02-04

3147 Live-bearing cockroach genome reveals convergent evolutionary mechanisms linked to viviparity in insects and beyond

Fouks, B.; Harrison, M. C.; Mikhailova, A. A.; Marchal, E.; English, S.; Carruthers, M.; Jennings, E. C.; Pippel, M.; Attardo, G. M.; Benoit, J. B.; Bornberg-Bauer, E.; Tobe, S. S.

10.1101/2022.02.03.478960 — genomics — Posted on 2022-02-04

3148 A Prism Vote Framework for Individualized Risk Prediction of Traits in Genome-wide Sequencing Data of Multiple Populations

Xia, X.; Sun, R.; Zhang, Y.; Wei, Y. Y.; Li, Q.; Chong, M. K. C.; Wu, W. K. K.; Zee, B. C.-Y.; Tang, H.; Wang, M. H.

10.1101/2022.02.02.478767 — genetics — Posted on 2022-02-04

3149 Genetic population structure across Brittany and the downstream Loire basin provides new insights on the demographic history of Western Europe

Alves, I.; Giemza, J.; Blum, M.; Bernhardsson, C.; Chatel, S.; Karakachoff, M.; Saint Pierre, A.; Herzig, A. F.; Olaso, R.; Monteil, M.; Gallien, V.; Cabot, E.; Svensson, E.; Bacq Daian, D.; Baron, E.; Berthellier, C.; Besse, C.; Blanche, H.; Bocher, O.; Boland, A.; Bonnaud, S.; Charpentier, E.; Dandine-Roulland, C.; Ferec, C.; Fruchet, C.; Lecointe, S.; Le Floch, E.; Ludwig, T. E.; Marenne, G.; Meyer, V.; Quellery, E.; Racimo, F.; Rouault, K.; Sandron, F.; Schott, J.-J.; Velo Suarez, L.; Violleau, J.; Willerslev, E.; Coativy, Y.; Jezequel, M.; Le Bris, D.; Nicolas, C.; Pailler, Y.; Goldberg,

10.1101/2022.02.03.478491 — genetics — Posted on 2022-02-04

3150 Evidence for independent processing of shape by vision and touch

Miller, R. L.; Sheinberg, D. L.

10.1101/2022.02.01.478696 — neuroscience — Posted on 2022-02-04

3151 Human orbitofrontal cortex signals decision outcomes to sensory cortex during behavioural adaptations

Wang, B. A.; Veismann, M.; Banerjee, A.; Pleger, B.

10.1101/2022.02.02.478729 — neuroscience — Posted on 2022-02-04

3152 No evidence that post-training D2R dopaminergic drug administration affects differential fear responding in rats

Schroyens, N.; Vercammen, L.; Ozcan, B.; Ossorio Salazar, V. A.; Zaman, J.; De Bundel, D.; Beckers, T.; Luyten, L.

10.1101/2022.02.02.478781 — neuroscience — Posted on 2022-02-04

3153 Scratching bouts are modeled as Bernoulli trials until successful itch-extinguishing in mice

Honda, K.; Tominaga, M.; Takamori, K.

10.1101/2022.02.03.478919 — neuroscience — Posted on 2022-02-04

3154 High resolution micro-CT imaging in mice stroke models: from 3D detailed infarct characterization to automatic area segmentation

Pinto, R.; Matula, J.; Gomez-Lazaro, M.; Sousa, M.; Zikmund, T.; Kaiser, J.; Gomes, J. R.

10.1101/2022.02.02.478782 — neuroscience — Posted on 2022-02-04

3155 Sensory target detection at local and global time scales dissociates modality-specific and supramodal dynamics in the cortical hierarchy

Niedernhuber, M.; Raimondo, F.; SITT, J.; Bekinschtein, T.

10.1101/2022.02.02.478851 — neuroscience — Posted on 2022-02-04

3156 The outer-hair-cell RC time constant: A feature, not a bug, of the mammalian cochlea

Altoe', A.; Shera, C. A.

10.1101/2022.02.02.478769 — neuroscience — Posted on 2022-02-04

3157 A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with progressive motor and cognitive decline

Weiss, A. R.; Liguore, W. A.; Brandon, K.; Wang, X.; Liu, Z.; Domire, J. S.; Button, D.; Kroenke, C. D.; McBride, J. L.

10.1101/2022.02.02.478920 — neuroscience — Posted on 2022-02-04

3158 A novel hidden Markov approach to studying dynamic functional connectivity states in human neuroimaging

Hussain, S.; Langley, J.; Seitz, A. R.; Peters, M. A. K.; Hu, X.

10.1101/2022.02.02.478844 — neuroscience — Posted on 2022-02-04

3159 Poor matching of action codes challenges 'mirroring' in macaque F5 mirror neurons

Pomper, J. K.; Shams-Ahmar, M.; Wen, S.; Bunjes, F.; Thier, P.

10.1101/2022.02.01.478703 — neuroscience — Posted on 2022-02-04

3160 Gamma Oscillations and Emotional Memory

Luther, L.; de Voogd, L. D.; Hagenaars, M. A.; Jensen, O.

10.1101/2022.02.02.478869 — neuroscience — Posted on 2022-02-04

3161 Musical expertise shapes visual-melodic memory integration

Ploner, C. J.; Hoffmann, M.; Schmidt, A.

10.1101/2022.02.03.478977 — neuroscience — Posted on 2022-02-04

3162 An integrative approach: using transcriptomic data and network analysis of transcriptional reprogramming in tomato response to PSTVd variants

Padilla, K. A.; Moreno, O. Z.; Herrera-Oropeza, G. E.; Limas, M. A. J.; Abrahamiam, P.; Hammond, R. W.; Hernandez-Rosales, M.

10.1101/2022.02.02.478822 — systems biology — Posted on 2022-02-04

3163 Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system - no evidence for a role of neuronal P2X7 receptors in colitis

Jooss, T.; Zhang, J.; Rezzonico-Jost, T.; Rissiek, B.; Koch-Nolte, F.; Magnus, T.; Zierler, S.; Schemann, M.; Grassi, F.; Nicke, A.

10.1101/2022.02.02.478704 — physiology — Posted on 2022-02-04

3164 Characterization of the adult zebrafish electrocardiogram

Arel, E.; Rolland, L.; Thireau, J.; Torrente, A.; Bechard, E.; Bride, J.; Jopling, C.; Demion, M.; Le Guennec, J.-Y.

10.1101/2022.02.02.478776 — physiology — Posted on 2022-02-04

3165 Accurate and robust inference of genetic ancestry from cancer-derived molecular data across genomic platforms

Belleau, P.; Deschenes, A.; Tuveson, D. A.; Krasnitz, A.

10.1101/2022.02.01.478737 — bioinformatics — Posted on 2022-02-04

3166 ORFanID: A Web-Based Search Engine for the Discovery and Identification of Orphan and Taxonomically Restricted Genes

Gunasekera, R. S.; Raja, K. K. B.; Hewapathirana, S.; Galbadage, T.; Tundrea, E.; Gunasekera, V.; Nelson, P. A.

10.1101/2022.02.01.478498 — bioinformatics — Posted on 2022-02-04

3167 Systematic lncRNA mapping to genome-wide co-essential pathways uncovers cancer dependency on uncharacterized lncRNAs

Mitra, R.; Adams, C. M.; Eischen, C. M.

10.1101/2022.02.03.478941 — bioinformatics — Posted on 2022-02-04

3168 Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography based Blood Flow Quantification

Nam, A. S.; Vakoc, B. J.; Braaf, B.

10.1101/2022.02.01.478558 — bioengineering — Posted on 2022-02-04

3169 Residual DNA in enzymes may pose a challenge for DIY RNA sequencing protocols: how to deal

Krivoy, A.; Botsmanov, Y.; Cheranev, V.; Shmitko, A.; Belova, V.; Moskalenko, V.; Afasizhev, R.; Shut, A.; Korostin, D.; Rebrikov, D.

10.1101/2022.02.02.478843 — genomics — Posted on 2022-02-04

3170 Melanism in a wild sifaka population: Darker where cold and fragmented

Tapanes, E.; Kamilar, J. M.; Nukala, M.; Irwin, M. T.; Bradley, B. J.

10.1101/2022.02.02.478891 — evolutionary biology — Posted on 2022-02-04

3171 Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

Szego, E. M.; Malz, L.; Bernhardt, N.; Roesen-Wolff, A.; Falkenburger, B. H.; Luksch, H.

10.1101/2022.02.02.478854 — neuroscience — Posted on 2022-02-04

3172 Heroin Self-Administration Induces Altered Dopamine Terminal Dynamics in the Nucleus Accumbens

George, B. E.; Dawes, M. H.; Peck, E. G.; Jones, S. R.

10.1101/2022.02.02.478890 — neuroscience — Posted on 2022-02-04

3173 An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

Nizamoglu, M.; de Hilster, R. H. J.; Zhao, F.; Sharma, P. K.; Borghuis, T.; Harmsen, M. C.; Burgess, J. K.

10.1101/2022.02.02.478812 — pathology — Posted on 2022-02-04

3174 Deep Immunophenotyping Reveals Endometriosis is Marked by Dysregulation of the Mononuclear Phagocytic System in Endometrium and Peripheral Blood

Vallve Juanico, J.; George, A. F.; Sen, S.; Thomas, R.; Shin, M.-G.; Kushnoor, D.; Vasquez, J. J.; Irwin, J. C.; Roan, N. R.; Combes, A. J.; Giudice, L. C.

10.1101/2022.02.02.478809 — immunology — Posted on 2022-02-04

3175 Movement characteristics impact decision-making and vice versa

Carsten, T.; Fievez, F.; Duque, J.

10.1101/2022.02.02.478832 — neuroscience — Posted on 2022-02-04

3176 Within-individual consistency and between-individual variation in the shapes of eggs laid by tree swallows (Tachycineta bicolor)

Taff, C. C.; Ryan, T. A.; Uehling, J. J.; Injaian, A. S.; Vitousek, M. N.

10.1101/2022.02.02.478835 — zoology — Posted on 2022-02-04

3177 Artificial soils reveal individual factor controls on microbial processes

Del Valle, I.; Gao, X.; Ghezzehei, T. A.; Silberg, J. J.; Masiello, C. A.

10.1101/2022.02.01.478713 — systems biology — Posted on 2022-02-04

3178 Rabbit hindlimb kinematics and ground contact pressure during the stance phase of hopping gait

Hall, P. T.; Stubbs, C.; Anderson, D. E.; Greenacre, C. B.; Crouch, D. L.

10.1101/2022.02.02.478798 — systems biology — Posted on 2022-02-04

3179 Deepwater Horizon crude oil reduces aerobic capacity of birds

Goodchild, C. G.; Krall, J. B.; Santhanakrishnan, A.; DuRant, S. E.

10.1101/2022.02.02.478827 — pharmacology and toxicology — Posted on 2022-02-04

3180 Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

Vastrad, B. M.; Vastrad, C. M.

10.1101/2022.02.03.478930 — bioinformatics — Posted on 2022-02-04

3181 An interpretable and versatile machine learning approach for oocyte phenotyping

Letort, G.; Eichmuller, A.; Da Silva, C.; Nikalayevich, E.; Labrune, E.; Wolf, J.-P.; Terret, M.-E.; Verlhac, M.-H.

10.1101/2022.02.01.478709 — bioinformatics — Posted on 2022-02-04

3182 Single-Cell Transcriptome Analysis Identifies Novel Biomarkers Involved in Major Liver Cancer Subtypes

Swain, A. K.; Pandey, P.; Sera, R.; Yadav, P.

10.1101/2022.02.01.478756 — genomics — Posted on 2022-02-04

3183 Bergerac Strains of C. elegans Revisited: Expansion of Tc1 elements Impose a Significant Genomic and Fitness Cost

Daigle, A. T.; Deiss, T. C.; Melde, R. H.; Bergthorsson, U.; Katju, V.

10.1101/2022.02.02.478770 — evolutionary biology — Posted on 2022-02-04

3184 Plasma ST6Gal1 is Dispensable for IgG Sialylation

Oswald, D. M.; Lehoux, S. D.; Zhou, J. Y.; Glendenning, L. M.; Cummings, R. D.; Cobb, B. A.

10.1101/2022.02.01.478679 — immunology — Posted on 2022-02-04

3185 Primary human macrophages exhibit a modest inflammatory response early in SARS-CoV-2 infection

Zhang, Z.; Penn, R.; Barclay, W. S. S.; Giotis, E. S.

10.1101/2022.02.02.478897 — microbiology — Posted on 2022-02-04

3186 Affective arousal explains infant gaze following under various social context

Ishikawa, M.; Senju, A.; Kato, M.; Itakura, S.

10.1101/2022.02.04.479127 — animal behavior and cognition — Posted on 2022-02-04

3187 Superstitious learning of abstract order from random reinforcement

Jin, Y.; Jensen, G.; Gottlieb, J. P.; Ferrera, V. P.

10.1101/2022.02.02.478909 — animal behavior and cognition — Posted on 2022-02-04

3188 Extinction Risk of Sonoran Desert Annuals Following Potential Changes in Precipitation Regimes

Cuello, W. S.; Schreiber, S. J.; Gremer, J. R.; Venable, L.; Trimmer, P. C.; Sih, A.

10.1101/2022.02.02.478887 — ecology — Posted on 2022-02-04

3189 mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

Gagne, M.; Moliva, J. I.; Foulds, K. E.; Andrew, S. F.; Flynn, B. J.; Werner, A. P.; Wagner, D. A.; Teng, I.-T.; Lin, B. C.; Moore, C.; Jean-Baptiste, N.; Carroll, R.; Foster, S. L.; Patel, M.; Ellis, M.; Edara, V.-V.; Maldonado, N. V.; Minai, M.; McCormick, L.; Honeycutt, C. C.; Nagata, B. M.; Bock, K. W.; Dulan, C. N. M.; Cordon, J.; Todd, J.-P. M.; McCarthy, E.; Pessaint, L.; Van Ry, A.; Narvaez, B.; Valentin, D.; Cook, A.; Dodson, A.; Steingrebe, K.; Flebbe, D. R.; Nurmukhambetova, S. T.; Godbole, S.; Henry, A. R.; Laboune, F.; Roberts-Torres, J.; Lorang, C. G.; Amin, S.; Trost, J.; Naisan

10.1101/2022.02.03.479037 — immunology — Posted on 2022-02-04

3190 Neural mechanism of acute stress management by trace aminergic signalling in the lateral habenula

Yang, S. H.; Yang, E.; Lee, J.; Kim, J. Y.; Yoo, H.; Park, H. S.; Jung, J. T.; Lee, D.; Chun, S.; Lee, H. W.; Kim, H.

10.1101/2022.02.02.478114 — neuroscience — Posted on 2022-02-04

3191 Graph theoretical analysis reveals the adaptive role of the left ventral occipito-temporal cortex in the brain networks during speech processing

Wang, S.; Planton, S.; Chanoine, V.; Sein, J.; Anton, J.-L.; Nazarian, B.; Dubarry, A.-S.; Pallier, C.; Pattamadilok, C.

10.1101/2022.02.03.478936 — neuroscience — Posted on 2022-02-04

3192 Modulation of stress-related behaviour by hypothalamic engagement of preproglucagon neurons in the nucleus of the solitary tract

Holt, M. K.; Valderrama, N.; Polanco, M. J.; Rinaman, L.

10.1101/2022.02.04.479117 — neuroscience — Posted on 2022-02-04

3193 ABA signaling prevents phosphodegradation of the Arabidopsis SR45 splicing factor to negatively autoregulate inhibition of early seedling development

Albuquerque-Martins, R.; Szakonyi, D.; Rowe, J.; Jones, A. M.; Duque, P.

10.1101/2022.02.03.479016 — plant biology — Posted on 2022-02-04

3194 De novo stem cell establishment in meristems requires repression of organ boundary cell fate

Nicolas, A.; Maugarny-Cales, A.; Adroher, B.; Chelysheva, L.; Li, Y.; Burguet, J.; Bagman, A.-M.; Smit, M. E.; Brady, S. M.; Li, Y.; Laufs, P.

10.1101/2022.02.03.478990 — plant biology — Posted on 2022-02-04

3195 GWAShub: A Web-based Resource to Democratize Genome-Wide Association Studies in Crop Plants

Daware, A.; Srivastava, R.; Das, D.; Malik, N.; Tyagi, A. K.; Parida, S. K.

10.1101/2022.02.03.479034 — bioinformatics — Posted on 2022-02-04

3196 Genomic signatures of host-specific selection in a parasitic plant

Bellis, E. S.; von Munchow, C. S.; Odero, C. O.; Kronberger, A.; Kelly, E.; Xia, T.; Huang, X.; Wicke, S.; Runo, S. M.; dePamphilis, C. W.; Lasky, J. R.

10.1101/2022.02.01.478712 — evolutionary biology — Posted on 2022-02-04

3197 Monitoring rapid evolution of plant populations at scale with Pool-Sequencing

Czech, L.; Peng, Y.; Spence, J. P.; Lang, P. L. M.; Bellagio, T.; Hildebrandt, J.; Fritschi, K.; Schwab, R.; Rowan, B.; GrENE-net consortium, ; Weigel, D.; Scheepens, J. F.; Vasseur, F.; Exposito-Alonso, M.

10.1101/2022.02.02.477408 — evolutionary biology — Posted on 2022-02-04

3198 Gal1 repression memory in budding yeast

Schuh, L.; Kukhtevich, I.; Bheda, P.; Schulz, M.; Bordukova, M.; Schneider, R.; Marr, C.

10.1101/2022.02.03.478948 — systems biology — Posted on 2022-02-04

3199 Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants

Houston, D. W.; Elliott, K. L.; Coppenrath, K.; Wlizla, M.; Horb, M. E.

10.1101/2022.02.02.478872 — developmental biology — Posted on 2022-02-04

3200 Novel neutrophil subsets associated with sepsis, vascular dysfunction and metabolic alterations identified using systems immunology

Martinelli, R.; Parthasarathy, U.; Kuang, Y.; Thakur, G.; Hogan, J. D.; Wyche, T. P.; Norton, J. E.; Killough, J. R.; Sana, T. R.; Beakes, C.; Shyong, B.; Zhang, R. N.; Gutierrez, D. A.; Filbin, M.; Christiani, D. C.; Therien, A. G.; Woelk, C. H.; White, C. H.

10.1101/2022.02.01.478658 — immunology — Posted on 2022-02-04

3201 Worldwide analysis of reef surveys sorts coral taxa by (adaptive) response to heat stress

Selmoni, O.; Lecellier, G.; Berteaux-Lecellier, V.; Joost, S.

10.1101/2021.10.29.466412 — ecology — Posted on 2022-02-04

3202 Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

Jakobs, M. A.; Zemel, A.; Franze, K.

10.1101/2021.06.03.446862 — cell biology — Posted on 2022-02-04

3203 Plasmodium DDI1 is a potential dual-therapeutic target and essential chromatin-associated protein

Tanneru, N.; Nivya, M. A.; Adhikari, N.; Saxena, K.; Rizvi, Z.; Sudhakar, R.; Nagwani, A. K.; Atul, ; Al-Nihmi, F. M. A.; Arun Kumar, K.; Sijwali, P. S.

10.1101/2021.10.29.466443 — cell biology — Posted on 2022-02-04

3204 Global diversity and distribution of prophages are lineage-specific within the Ralstonia solanacearum plant pathogenic bacterium species complex

Greenrod, S. T.; Stoycheva, M.; Elphinstone, J.; Friman, V.-P.

10.1101/2021.10.20.465097 — microbiology — Posted on 2022-02-04

3205 Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity and episodic memory

Coenjaerts, M.; Trimborn, I.; Adrovic, B.; Stoffel-Wagner, B.; Cahill, L.; Philipsen, A.; Hurlemann, R.; Scheele, D.

10.1101/2021.11.22.469500 — neuroscience — Posted on 2022-02-04

3206 Structuring time: The hippocampus constructs sequence memories that generalize temporal relations across experiences

Bellmund, J. L. S.; Deuker, L.; Montijn, N. D.; Doeller, C. F.

10.1101/2021.04.23.440002 — neuroscience — Posted on 2022-02-04

3207 Emergent Statistical Laws in Single-Cell Transcriptomic Data

Lazzardi, S.; Valle, F.; Mazzolini, A.; Scialdone, A.; Caselle, M.; Osella, M.

10.1101/2021.06.16.448706 — systems biology — Posted on 2022-02-04

3208 Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

Neyret-Kahn, H.; Fontugne, J.; Meng, X.-Y.; Groeneveld, C. S.; Cabel, L.; Ye, T.; Guyon, E.; Krucker, C.; Dufour, F.; Chapeaublanc, Élodie; Rapinat, A.; Jeffery, D. C. B.; Neuzillet, Y.; Lebret, T.; Gentien, D.; Davidson, I.; Allory, Y.; Bernard-Pierrot, I.; Radvanyi, F.

10.1101/2022.01.11.475197 — cancer biology — Posted on 2022-02-04

3209 Force sensing on cells and tissues by atomic force microscopy

Holuigue, H.; Lorenc, E.; Chighizola, M.; Schulte, C.; Varinelli, L.; Deraco, M.; Guaglio, M.; Gariboldi, M.; Podesta', A.

10.1101/2022.02.03.478991 — biophysics — Posted on 2022-02-04

3210 Non canonical scaffold-type ligase complex mediates protein UFMylation

Peter, J. J.; Magnussen, H. M.; DaRosa, P. A.; Millrine, D.; Matthews, S. P.; Lamoliatte, F.; Sundaramoorthy, R.; Kopito, R. R.; Kulathu, Y.

10.1101/2022.01.31.478489 — biochemistry — Posted on 2022-02-04

3211 Late-acting self-incompatible system, preferential allogamy and delayed selfing in the heteromorphic invasive populations of Ludwigia grandiflora subsp. hexapetala

Portillo Lemus, L. O.; Harang, M.; Bozec, M.; Haury, J.; Stoeckel, S.; Barloy, D.

10.1101/2021.07.15.452457 — ecology — Posted on 2022-02-04

3212 Neurocomputational mechanisms of confidence in self and others

Bang, D.; Moran, R.; Daw, N. D.; Fleming, S. M.

10.1101/2021.03.05.434065 — neuroscience — Posted on 2022-02-04

3213 Reliable and efficient parameter estimation using approximate continuum limit descriptions of stochastic models

Simpson, M. J.; Baker, R. E.; Buenzli, P. R.; Nicholson, R.; Maclaren, O. J.

10.1101/2022.02.02.478913 — biophysics — Posted on 2022-02-04

3214 Oncogenic protein condensates modulate cell signal perception and drug tolerance

Gonzalez-Martinez, D.; Roth, L.; Mumford, T.; Tulpule, A.; Bivona, T. G.; Bugaj, L. J.

10.1101/2022.02.02.478845 — cancer biology — Posted on 2022-02-04

3215 Canonical BMP2/4 signaling degrades SOX2 in glioblastoma propagating cells.

Comadamore, F.; Amador-Arjona, A.; Farhy, C.; Huang, C.-T.; Kornblum, H.; Terskikh, A.

10.1101/2022.02.03.479056 — cancer biology — Posted on 2022-02-04

3216 Peptide-based drug predictions for cancer therapy using deep learning

Sun, Y.-Y.; Lin, T.-T.; Cheng, W.-C.; Lu, I.-H.; Chen, S.-H.; Lin, C.-Y.

10.1101/2022.02.01.478580 — cancer biology — Posted on 2022-02-04

3217 Cytocapsulae and cytocapsular tubes are golden targets for precise, effective and efficient cancer diagnosis and therapy in 307 kinds of liquid and solid cancers

Yi, T.; Wagner, G.

10.1101/2022.02.03.478975 — cancer biology — Posted on 2022-02-04

3218 Single-cell transcriptomics reveals varying degrees of epithelial-mesenchymal plasticity in lymph node metastasis from oral cavity squamous cell carcinoma

Horny, K.; Sproll, C.; Peiffer, L.; Furtmann, F.; Gerhardt, P.; Gravemeyer, J.; Stoecklein, N. H.; Spassova, I.; Becker, J. C.

10.1101/2022.02.03.478962 — cancer biology — Posted on 2022-02-04

3219 Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease

Jafari, N.; Kolla, M.; Pompa, I. R.; Qiu, Y.; Ennis, C. S.; Mori, J.; Mahdaviani, K.; Halpin, M.; Gignac, G. A.; Heaphy, C. M.; Denis, G. V.

10.1101/2022.02.01.478722 — cancer biology — Posted on 2022-02-04

3220 Augmented efficacy of uttroside B over sorafenib in a murine model of human hepatocellular carcinoma

Swetha, M.; Keerthana, C. K.; Rayginia, T. P.; Nath, L. R.; Haritha, N. H.; Kalimuthu, K.; Jannet, S.; Pillai, S.; Harikumar, K. B.; Sundaram, S.; Anto, N. P.; Wu, D. H.; Lankalapalli, R. S.; Towner, R.; Isakov, N.; Sathyaseelan, D.; Anto, R. J.

10.1101/2022.02.01.478749 — cancer biology — Posted on 2022-02-04

3221 PRMT5 regulates ATF4 transcript splicing and oxidative stress response

Szewczyk, M. M.; Luciani, G. M.; Vu, V.; Murison, A.; Dilworth, D.; Lupien, M.; Arrowsmith, C. H.; Minden, M. D.; Barsyte-Lovejoy, D.

10.1101/2022.02.02.478789 — cancer biology — Posted on 2022-02-04

3222 p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

Murai, K.; Dentro, S.; Ong, S. H.; Sood, R.; Fernandez-Antoran, D.; Herms, A.; Kostiou, V.; Hall, B. A.; Gerstung, M.; Jones, P. H.

10.1101/2022.02.03.478951 — cancer biology — Posted on 2022-02-04

3223 Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

Anstee, J. E.; Opzoomer, J. W.; Dean, I.; Muller, H. P.; Bahri, M.; Liakath-Ali, K.; Liu, Z.; Choy, D.; Caron, J.; Sosnowska, D.; Beatson, R.; Muliaditan, T.; An, Z.; Gillett, C. E.; Lan, G.; Zou, X.; Watt, F. M.; Ng, T.; Burchell, J. M.; Kordasti, S.; Withers, D. R.; Lawrence, T.; Arnold, J. N.

10.1101/2022.02.03.478952 — cancer biology — Posted on 2022-02-04

3224 Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

Stuchell-Brereton, M. D.; Zimmerman, M. I.; Miller, J. J.; Mallimadugula, U. L.; Incicco, J. J.; Roy, D.; Smith, L. G.; Baban, B.; DeKoster, G. T.; Frieden, C.; Bowman, G. R.; Soranno, A.

10.1101/2022.02.02.478828 — biophysics — Posted on 2022-02-04

3225 A fractal polymer with loops recapitulates key features of chromosome organization

Polovnikov, K. E.; Belan, S.; Imakaev, M.; Brandao, H.; Mirny, L.

10.1101/2022.02.01.478588 — biophysics — Posted on 2022-02-04

3226 Force sensing on cells and tissues by atomic force microscopy

Holuigue, H.; Lorenc, E.; Chighizola, M.; Schulte, C.; Varinelli, L.; Deraco, M.; Guaglio, M.; Gariboldi, M.; Podesta', A.

10.1101/2022.02.03.478991 — biophysics — Posted on 2022-02-04

3227 Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

Nakajima, K.; Yamaguchi, K.; Noji, M.; Aguirre, C.; Ikenaka, K.; Mochizuki, H.; Zhou, L.; Ogi, H.; Ito, T.; Narita, I.; Gejyo, F.; Naiki, H.; Yamamoto, S.; Goto, Y.

10.1101/2022.02.01.478730 — biophysics — Posted on 2022-02-04

3228 Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

Cada, A. K.; Remec Pavlin, M.; Castillo, J. P.; Tong, A. B.; Larsen, K. P.; Ren, X.; Yokom, A. L.; Tsai, F.-C.; Bassereau, P.; Bustamante, C. J.; Hurley, J. H.

10.1101/2022.02.03.479062 — biophysics — Posted on 2022-02-04

3229 Identification of enhancer-like elements defines regulatory networks active in planarian adult stem cells

Neiro, J.; Sridhar, D.; Dattani, A.; Aboobaker, A.

10.1101/2022.02.03.479047 — developmental biology — Posted on 2022-02-04

3230 High-Resolution Ultrasound and Speckle Tracking: a non-invasive approach to assess in vivo gastrointestinal motility during development

Sicard, P.; Falco, A.; Faure, S.; Thireau, J.; Lindsey, S. E.; Chauvet, N.; de Santa Barbara, P.

10.1101/2022.02.01.478689 — developmental biology — Posted on 2022-02-04

3231 Identification of a suitable endogenous control miRNA in bone aging and senescence

Kaur, J.; Saul, D.; Doolittle, M. L.; Rowsey, J. L.; Vos, S. J.; Farr, J. N.; Khosla, S.; Monroe, D.

10.1101/2022.02.03.479003 — cell biology — Posted on 2022-02-04

3232 Epithelia are multiscale active liquid crystals

Armengol-Collado, J.-M.; Carenza, L. N.; Eckert, J.; Krommydas, D.; Giomi, L.

10.1101/2022.02.01.478692 — biophysics — Posted on 2022-02-04

3233 Constraint-based modeling identifies metabolic vulnerabilities during the epithelial to mesenchymal transition

Campit, S. E.; Keshamouni, V. G.; Chandrasekaran, S.

10.1101/2022.01.31.478483 — cancer biology — Posted on 2022-02-03

3234 Accelerating long-read analysis on modern CPUs

Kalikar, S.; Jain, C.; Md, V.; Misra, S.

10.1101/2021.07.21.453294 — genomics — Posted on 2022-02-03

3235 Fetal origin of sex-bias brain aging

Islam, M.; Strawn, M.; Behura, S. K.

10.1101/2022.02.02.478867 — genomics — Posted on 2022-02-03

3236 Prediction of prophages and their host ranges in pathogenic and commensal Neisseria species

Orazi, G.; Collins, A. J.; Whitaker, R. J.

10.1101/2021.12.16.473053 — microbiology — Posted on 2022-02-03

3237 Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Yang, Z.; Dam, K.-M. A.; Bridges, M. D.; Hoffmann, M. A. G.; DeLaitsch, A. T.; Gristick, H. B.; Escolano, A.; Gautam, R.; Martin, M. A.; Nussenzweig, M.; Hubbell, W.; Bjorkman, P. J.

10.1101/2021.11.02.466200 — immunology — Posted on 2022-02-03

3238 Increasing temporal variance leads to stable species range limits

Benning, J. W.; Hufbauer, R. A.; Weiss-Lehman, C.

10.1101/2021.08.09.455156 — evolutionary biology — Posted on 2022-02-03

3239 Oscillations and variability in neuronal systems: interplay of autonomous transient dynamics and fast deterministic fluctuations

Pena, R. F.; Rotstein, H. G.

10.1101/2021.06.14.448371 — neuroscience — Posted on 2022-02-03

3240 A model of working memory for latent representations

Hedayati, S.; O'Donnell, R.; Wyble, B.

10.1101/2021.02.07.430171 — neuroscience — Posted on 2022-02-03

3241 Homologous recombination repair creates mutations in the non-coding genome that alter Topoisomerase-1 cleavage sites & orchestrates irinotecan resistance

Kumar, S.; Gahramanov, V.; Yaglom, J.; Patel, S.; Kaczmarczyk, L.; Alexandrov, I.; Gerlitz, G.; Salmon-Divon, M.; Sherman, M. Y.

10.1101/2021.11.26.470089 — cancer biology — Posted on 2022-02-03

3242 Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

Kar, M.; Dar, F.; Welsh, T. J.; Vogel, L.; Kuhnemuth, R.; Majumdar, A.; Krainer, G.; Franzmann, T. M.; Alberti, S.; Seidel, C. A. M.; Knowles, T.; Hyman, A. A.; Pappu, R. V.

10.1101/2022.02.03.478969 — biophysics — Posted on 2022-02-03

3243 Bayesian machine learning analysis of single-molecule fluorescence colocalization images

Ordabayev, Y. A.; Friedman, L. J.; Gelles, J.; Theobald, D.

10.1101/2021.09.30.462536 — biophysics — Posted on 2022-02-03

3244 Identifying strengths and weaknesses of methods for computational network inference from single cell RNA-seq data

Stone, M.; Li, J.; McCalla, S. G.; Fotuhi Siahpirani, A.; Periyasamy, V.; Shin, J.; Roy, S.

10.1101/2021.06.01.446671 — bioinformatics — Posted on 2022-02-03

3245 Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics

Janetzko, J.; Kise, R.; Barsi-Rhyne, B.; Siepe, D. H.; Heydenreich, F. M.; Masureel, M.; Kawakami, K.; Garcia, K. C.; Von Zastrow, M.; Inoue, A.; Kobilka, B. K.

10.1101/2021.10.09.463790 — biochemistry — Posted on 2022-02-03

3246 Long-read and chromosome-scale assembly of the hexaploid wheat genome achieves high resolution for research and breeding

Aury, J.-M.; Engelen, S.; Istace, B.; Monat, C.; Lasserre-Zuber, P.; Belser, C.; Cruaud, C.; Rimbert, H.; Leroy, P.; Arribat, S.; Dufau, I.; Bellec, A.; Grimbichler, D.; Papon, N.; Paux, E.; Ranoux, M.; Alberti, A.; Wincker, P.; Choulet, F.

10.1101/2021.08.24.457458 — genomics — Posted on 2022-02-03

3247 ATP synthase is essential for high conductance but not low conductance Mitochondrial Permeability Transition

Neginskaya, M. A.; Morris, S. E.; Pavlov, E. V.

10.1101/2021.11.16.468842 — cell biology — Posted on 2022-02-03

3248 Release of HIV-1 particles from the viral compartment in macrophages requires an associated cytoskeleton and is driven by mechanical constraints

Rodrigues, V.; Taheraly, S.; Maurin, M.; San-Roman, M.; Granier, E.; Hanouna, A.; BENAROCH, P.

10.1101/2021.12.31.474638 — cell biology — Posted on 2022-02-03

3249 Phylogenetic diversity analysis of shotgun metagenomic reads describes gut microbiome development and treatment effects in the post-weaned pig

Gaio, D.; DeMaere, M. Z.; Anantanawat, K.; Eamens, G. J.; Zingali, T.; Falconer, L.; Chapman, T. A.; Djordjevic, S. P.; Darling, A. E.

10.1101/2020.07.20.211326 — microbiology — Posted on 2022-02-03

3250 Electrophysiological markers of fairness and selfishness revealed by a combination of Dictator and Ultimatum Games

Miraghaie, A. M.; Pouretemad, H.; Villa, A. E. P.; Mazaheri, M. A.; Khosrowabadi, R.; Lintas, A.

10.1101/2021.08.23.457310 — neuroscience — Posted on 2022-02-03

3251 NOMIS: Quantifying morphometric deviations from normality over the lifetime of the adult human brain

Potvin, O.; Dieumegarde, L.; Duchesne, S.; Alzheimer's Disease Neuroimaging Initiative and CIMA-Q,

10.1101/2021.01.25.428063 — neuroscience — Posted on 2022-02-03

3252 Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumor eEF1A antagonist SR-A3

Wang, H.; Yang, H.; Holm, M.; Oltion, K.; Tom, H.; Al-Khdhairawi, A. A. Q.; Weber, J.-F. F.; Blanchard, S.; Ruggero, D.; Taunton, J.

10.1101/2020.10.06.325498 — pharmacology and toxicology — Posted on 2022-02-03

3253 Sampling the conformational landscapes of transporters and receptors with AlphaFold2

del Alamo, D.; Sala, D.; Mchaourab, H.; Meiler, J.

10.1101/2021.11.22.469536 — biophysics — Posted on 2022-02-03

3254 Perilipin 5 interacts with Fatp4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport

Miner, G. E.; So, C. M.; Edwards, W.; Herring, L. E.; Coleman, R. A.; Klett, E. L.; Cohen, S.

10.1101/2022.02.03.479028 — cell biology — Posted on 2022-02-03

3255 SdiA, a Quorum Sensing Transcriptional Regulator, Enhanced the Drug Resistance of Cronobacter sakazakiiand Suppressed its Motility, Adhesion and Biofilm Formation

Cheng, C.; Yan, X.; Liu, B.; Jiang, T.; Zhou, Z.; Zhang, D.; Wang, H.; Chen, D.; Li, C.; Fang, T.

10.1101/2022.02.02.478922 — molecular biology — Posted on 2022-02-03

3256 Ecological insights into soil health according to the life-history traits and environment-wide associations of bacteria in agricultural soils

Wilhelm, R. C.; Amsili, J. P.; Kurtz, K. S.; van Es, H. M.; Buckley, D. H.

10.1101/2022.02.03.479020 — microbiology — Posted on 2022-02-03

3257 Epigenetic cell memory: The gene's inner chromatin modification circuit

Bruno, S.; Williams, R. J.; Del Vecchio, D.

10.1101/2022.02.02.476953 — synthetic biology — Posted on 2022-02-03

3258 Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors

Yuan, M.; Eberhart, C. G.; Pratilas, C. A.; Blakeley, J. O.; Davis, C.; Stojanova, M.; Reilly, K.; Meeker, A. K.; Heaphy, C. M.; Rodriguez, F. J.

10.1101/2022.02.03.479021 — cancer biology — Posted on 2022-02-03

3259 Lymphatic-Preserving Treatment Sequencing with Immune Checkpoint Inhibition Unleashes cDC1-Dependent Antitumor Immunity in HNSCC

Saddawi-Konefka, R.; O'Farrell, A.; Faraji, F.; Clubb, L.; Allevato, M. M.; Anang, N.-A. A. S.; Jensen, S. M.; Wang, Z.; Wu, V. H.; Yung, B. S.; Al Msari, R.; Franiak Pietryga, I.; Molinolo, A. A.; Mesirov, J. P.; Simon, A. B.; Fox, B. A.; Bui, J. D.; Sharabi, A.; Cohen, E. E. W.; Califano, J. A.; Gutkind, J. S.

10.1101/2022.02.01.478744 — cancer biology — Posted on 2022-02-03

3260 Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian Cancer

Sriramkumar, S.; Sood, R.; Huntington, T. D.; Ghobashi, A. H.; Wang, W.; Nephew, K. P.; OHagan, H. M.

10.1101/2022.02.01.478738 — cancer biology — Posted on 2022-02-03

3261 Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc

Garcia-Cuellar, M.-P.; Prinz, A.; Slany, R. K.

10.1101/2022.02.03.478956 — cancer biology — Posted on 2022-02-03

3262 Unraveling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent-RNA-Polymerase. An Unusual Active Site Leading to High Replication Rates.

Bignon, E.; Monari, A.

10.1101/2022.02.02.478873 — biophysics — Posted on 2022-02-03

3263 Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

Cavalieri, R.; Hazebroek, M. K.; Cotrim, C. A.; Lee, Y.; Kunji, E. R. S.; Jastroch, M.; Keipert, S.; Crichton, P. G.

10.1101/2022.02.03.478984 — biochemistry — Posted on 2022-02-03

3264 Structural features of mTORC2 that control substrate-specific activities.

Yu, Z.; Chen, J.; Takagi, E.; Wang, F.; Liu, X.; Jourbert, L.-M.; Saha, B.; Gleason, C.; Jin, M.; Li, C.; Nowotny, C.; Agard, D.; Cheng, Y.; Pearce, D.

10.1101/2022.02.03.478898 — biochemistry — Posted on 2022-02-03

3265 2'-O -methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

Drazkowska, K.; Baran, N.; Warminski, M.; Tomecki, R.; Depaix, A.; Cysewski, D.; Kasprzyk, R.; Kowalska, J.; Jemielity, J.; Sikorski, P. J.

10.1101/2022.02.03.478939 — biochemistry — Posted on 2022-02-03

3266 In silico structure-based analysis of the predicted protein-protein interaction of Syntaxin-18, a putative receptor of Peregrinus maidis Ashmead (Hemiptera: Delphacidae) with Maize mosaic virus glycoprotein

Castrosanto, M. A.; Clemente, A. J. N.; Whitfield, A. E.; Alviar, K.

10.1101/2022.02.02.478912 — biochemistry — Posted on 2022-02-03

3267 Proteostasis in ice: The role of heat shock proteins and ubiquitin in the freeze tolerance of the intertidal mussel, Mytilus trossulus

Gill, L. T.; Kennedy, J. R.; Marshall, K. E.

10.1101/2022.02.03.478032 — biochemistry — Posted on 2022-02-03

3268 A mono- and intralink filter (mi-filter) to improve false-discovery rates in cross-linking mass spectrometry data

Chen, X.; Sailer, C.; Kammer, K.-M.; Fuersch, J.; Eisele, M. R.; Sakata, E.; Stengel, F.

10.1101/2022.02.03.478943 — biochemistry — Posted on 2022-02-03

3269 Describing Chemical Kinetics in the Time Dimension with Mean Reaction Time

Park, C.

10.1101/2022.02.01.478700 — biochemistry — Posted on 2022-02-03

3270 Enhancing high-temperature degradation of polyethylene terephthalate through a synergistic division of enzyme labour between a solid-degrading thermostable cutinase and a reaction intermediate-degrading thermostable carboxylesterase

Mrigwani, A.; Thakur, B.; Guptasarma, P.

10.1101/2022.02.02.478778 — biochemistry — Posted on 2022-02-03

3271 Telomeres are shorter in wild Saccharomyces cerevisiae isolates than in domesticated ones

D'Angiolo, M.; Yue, J.-X.; De Chiara, M.; Barre, B. P.; Giraud Panis, M.-J.; Gilson, E.; Liti, G.

10.1101/2022.02.03.478944 — genomics — Posted on 2022-02-03

3272 Millennium-Old Pathogenic Mendelian Mutation Discovery for MultipleOsteochondromas from a Gaelic Medieval Graveyard.

Jackson, I.; Mattiangeli, V.; Cassidy, L. M.; Murphy, E.; Bradley, D. G.

10.1101/2022.02.02.478802 — genomics — Posted on 2022-02-03

3273 SKN-1 is a metabolic surveillance factor that monitors amino acid catabolism to control stress resistance

Frankino, P. A.; Siddiqi, T. F.; Bolas, T.; Bar-Ziv, R.; Gildea, H. K.; Zhang, H.; Higuchi-Sanabria, R.; Dillin, A.

10.1101/2022.02.03.479044 — genetics — Posted on 2022-02-03

3274 Exploring the lncRNA localization landscape within the retinal pigment epithelium under normal and stress conditions

Kaczynski, T. J.; Au, E. D.; Farkas, M. H.

10.1101/2022.02.03.479033 — genetics — Posted on 2022-02-03

3275 A Mouse Model with Complete Penetrance for Atrioventricular Septal Defect/Complete AV Canal

Li, Y.; Andersen, P.; Liu, X.; Moyer, A. J.; Kwon, C.; Reeves, R. H.

10.1101/2022.02.03.478994 — developmental biology — Posted on 2022-02-03

3276 Global chromatin mobility induced by a DSB is dictated by chromosomal conformation and defines the outcome of Homologous Recombination.

Garcia Fernandez, F.; Almayrac, E.; Carre Simon, A.; Batrin, R.; Khalil, Y.; Boissac, M.; Fabre, E.

10.1101/2022.02.03.478935 — molecular biology — Posted on 2022-02-03

3277 Real-time luminescence enables continuous drug-response analysis in adherent and suspension cell lines

Wandishin, C. M.; Robbins, C. J.; Tyson, D. R.; Harris, L. A.; Quaranta, V.

10.1101/2022.02.03.479010 — molecular biology — Posted on 2022-02-03

3278 Splicing inactivation generates hybrid mRNA-snoRNA transcripts targeted by cytoplasmic RNA decay

Liu, Y.; DeMario, S.; He, K.; Gibbs, M.; Barr, K.; Chanfreau, G. F.

10.1101/2022.02.02.478905 — molecular biology — Posted on 2022-02-03

3279 Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line

Aumer, T.; Gremmelmaier, C. B.; Runtsch, L. S.; Yesiltac, N.; Kaiser, S.; Traube, F. R.

10.1101/2022.02.03.476906 — molecular biology — Posted on 2022-02-03

3280 Two broadly conserved families of polyprenyl-phosphate transporters

Roney, I. J.; Rudner, D. Z.

10.1101/2022.02.03.479048 — microbiology — Posted on 2022-02-03

3281 Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin Against Cystic Fibrosis Pseudomonas aeruginosa

Murphy, R. A.; Coates, M.; Thrane, S.; Sabnis, A.; Harrison, J.; Schelenz, S.; Edwards, A. M.; Vorup-Jensen, T.; Davies, J. C.

10.1101/2022.02.03.478806 — microbiology — Posted on 2022-02-03

3282 Rapid aggregation of Staphylococcus aureus in synovial fluid is influenced by synovial fluid concentration, viscosity, and fluid dynamics-with evidence of polymer bridging

Stoodley, P.; Staats, A.; Burback, P. W.; Schwieters, A.; Li, D.; Sullivan, A.; Horswill, A.

10.1101/2022.02.02.478923 — microbiology — Posted on 2022-02-03

3283 Genomic rearrangements of mobile genetic elements associated with carbapenem resistance of Acinetobacter baumannii

Vijayakumar, S.; Jacob, J. J.; Vasudevan, K.; Mathur, P.; Ray, P.; Neeravi, A. R.; Baskaran, A.; Kirubananthan, A.; Anandan, S.; Biswas, I.; Walia, K.; Veeraraghavan, B.

10.1101/2022.02.03.478955 — microbiology — Posted on 2022-02-03

3284 Development and optimisation of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: evaluation of 5676 phase 1 passed structures

Chiu, W.; Verschueren, L.; Van den Eynde, C.; Buyck, C.; De Meyer, S.; Jochmans, D.; Bojkova, D.; Ciesek, S.; Cinatl, J.; De Jonghe, S.; Leyssen, P.; Neyts, J.; Van Loock, M.; Van Damme, E.

10.1101/2022.02.02.478671 — immunology — Posted on 2022-02-03

3285 COVID-19 infection enhances susceptibility to oxidative-stress induced parkinsonism

Smeyne, R. J.; Eells, J.; Chatterjee, D.; Byrne, M.; Akula, S. M.; Sriramula, S.; O'Rourke, D.; Schmidt, P.

10.1101/2022.02.02.478719 — neuroscience — Posted on 2022-02-03

3286 Discovery of a new but established population of the guppy in Germany

Bierbach, D.; Schutz, C.; Weimar, N.; Escurra Alegre, A.; Francisco, F. A.; Wersing, S.; O'Connor, O. L.; Kempkes, M.; Rose, U.; Miesen, F. W.; Habedank, M.; Jourdan, J.; Kabus, J.; Hof, D.; Hornung, S.; Emde, S.; Rueffert, L.; Lukas, J.

10.1101/2022.02.01.478389 — ecology — Posted on 2022-02-03

3287 Windborne migration amplifies insect-mediated pollination services

KongMing, W.; Huiru, J.; Yongqiang, L.; Hui, L.; Xaiokang, L.; Yunfei, P.; Chaoxing, H.; Kris A.G., W.; Xainyong, Z.

10.1101/2022.02.01.478668 — ecology — Posted on 2022-02-03

3288 Patterns of variation in canal and root number in human post-canine teeth

Gellis, J. J.; Foley, R.

10.1101/2022.02.01.478656 — developmental biology — Posted on 2022-02-03

3289 Transcriptomic analysis of aging mouse sciatic nerve reveals early pathways leading to sarcopenia

Comfort, N.; Gade, M.; Strait, M.; Merwin, S. J.; Antoniou, D.; Memou, A.; Rideout, H. J.; Corti, S.; Kariya, S.; Re, D. B.

10.1101/2022.02.01.478571 — neuroscience — Posted on 2022-02-03

3290 Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice

Traut, J.; Mengual, J. P.; Meijer, E. J.; McKillop, L. E.; Alfonsa, H.; Hoerder-Suabedissen, A.; Song, S. M.; Molnar, Z.; Akerman, C. J.; Vyazovskiy, V. V.; Krone, L. B.

10.1101/2022.02.01.478652 — neuroscience — Posted on 2022-02-03

3291 Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA

Nguyen, T.; Li, S.; Chang, J.; Watters, J.; Ng, H.; Osunsade, A.; David, Y.; Liu, S.

10.1101/2022.02.02.478883 — biophysics — Posted on 2022-02-03

3292 Beyond G1/S regulation: how cell size homeostasis is tightly controlled throughout the cell cycle?

Liu, X.; Yan, J.; Kirschner, M. W.

10.1101/2022.02.03.478996 — cell biology — Posted on 2022-02-03

3293 Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

Soerensen, S. G.; Shrikhande, A.; Poulsgaard, G. A.; Christensen, M. H.; Bertl, J.; Hoffmann, E. R.; Pedersen, J. S.

10.1101/2022.01.31.478445 — genomics — Posted on 2022-02-03

3294 Sex and age differences in cognitive bias and neural activation in response to cognitive bias

Hodges, T. E.; Lee, G. Y.; Noh, S.; Galea, L.

10.1101/2022.02.02.478831 — neuroscience — Posted on 2022-02-03

3295 Dissociable Roles of FEF Neurons in Initiating Saccades

Shams-Ahmar, M.; Thier, P.; Merrikhi, Y.

10.1101/2022.02.01.478650 — neuroscience — Posted on 2022-02-03

3296 Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations

Kiani, K.; Sanford, E. M.; Goyal, Y.; Raj, A.

10.1101/2022.02.03.478981 — bioinformatics — Posted on 2022-02-03

3297 Decoding rRNA Sequences for Improved Metagenomics in Sylvatic Mosquito Species

Koh, C.; Frangeul, L.; Blanc, H.; Ngoagouni, C.; Boyer, S.; Dussart, P.; Grau, N.; Girod, R.; Duchemin, J.-B.; Saleh, M. C.

10.1101/2022.02.01.478639 — bioinformatics — Posted on 2022-02-03

3298 Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway

Abou Azar, F.; Mugabo, Y.; Yuen, S.; Del Veliz, S.; Lavoie, G.; Roux, P. P.; Lim, G. E.

10.1101/2022.02.03.478896 — biochemistry — Posted on 2022-02-03

3299 Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

Contessoto, V. G.; Dudchenko, O.; Aiden, E. L.; Wolynes, P. G.; Onuchic, J. N.; Di Pierro, M.

10.1101/2022.02.01.478655 — genomics — Posted on 2022-02-03

3300 Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes and gene regulation

Choudhary, M. N.; Quaid, K.; Xing, X.; Schmidt, H.; Wang, T.

10.1101/2022.02.01.475239 — genomics — Posted on 2022-02-03

3301 Positive and relaxed selective pressures have both strongly influenced the evolution of cryonotothenioid fishes during their radiation in the freezing Southern Ocean

Bilyk, K.; Zhuang, X.; Papetti, C.

10.1101/2022.02.01.478646 — evolutionary biology — Posted on 2022-02-03

3302 Maternal transfer and long-term population effects of PCBs in Baltic grey seals using a new toxicokinetic-toxicodynamic population model

Mauritsson, K.; Desforges, J.-P.; Harding, K. C.

10.1101/2022.02.01.478642 — ecology — Posted on 2022-02-03

3303 Pyruvate supports RET-dependent mitochondrial ROS production necessary to control Mycobacterium avium infection in human primary macrophages

Rost, L. M.; Louet, C.; Bruheim, P.; FLO, T. H.; Gidon, A.

10.1101/2022.02.01.478654 — immunology — Posted on 2022-02-03

3304 A Spiking Neural Network Model of Rodent Head Direction calibrated with Landmark Free Learning.

Stentiford, R.; Knowles, T. C.; Pearson, M. J.

10.1101/2022.02.01.478640 — neuroscience — Posted on 2022-02-03

3305 Oncogenic c-Myc activity increases tolerance to proteotoxic and genotoxic stress through regulation of HSF1

Jones, J.; Kiso, K.; Bertoli, C.; de Bruin, R. A. M.

10.1101/2022.02.02.478796 — cancer biology — Posted on 2022-02-03

3306 AlphaFold accurately predicts distinct conformations based on oligomeric state of a de novo designed protein

Cummins, M. C.; Jacobs, T. M.; Teets, F. D.; DiMaio, F.; Tripathy, A.; Kuhlman, B.

10.1101/2022.02.02.478886 — biophysics — Posted on 2022-02-03

3307 Impact of cell size on morphogen gradient precision

Adelmann, J. A.; Vetter, R.; Iber, D.

10.1101/2022.02.02.478800 — developmental biology — Posted on 2022-02-03

3308 Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2

Mohamed, F. F.; Ge, C.; Cowling, R. T.; Ono, N.; Binrayes, A.-A.; Greenberg, B.; Kaartinen, V. M.; Franceschi, R. T.

10.1101/2022.02.03.479017 — developmental biology — Posted on 2022-02-03

3309 Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse through distinct adaptors

Kvalvaag, A.; Cespedes, P. F.; Valvo, S.; Saliba, D.; Kurz, E.; Korobchevskaya, K.; Dustin, M.

10.1101/2022.02.02.478780 — cell biology — Posted on 2022-02-03

3310 IZUMO1 is a sperm fusogen

Brukman, N. G.; Nakajima, K. P.; Valansi, C.; Li, X.; Higashiyama, T.; Podbilewicz, B.

10.1101/2022.02.01.478669 — cell biology — Posted on 2022-02-03

3311 Complementing the EGFR dynamic interactome using live-cell proximity labeling

van Gelder, C. A. G. H.; van Bergen, W.; van Breugel, P. C.; Altelaar, M.

10.1101/2022.02.02.478771 — cell biology — Posted on 2022-02-03

3312 Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission

Lach, R. S.; Qiu, C.; Kajbaf, E. Z.; Baxter, N. J.; Han, D.; Wang, A. Y.; Lock, H. M.; Chirikin, O.; Pruitt, B. L.; Wilson, M. Z.

10.1101/2022.02.01.478717 — cell biology — Posted on 2022-02-03

3313 Functional crosstalk between the carrier translocase machinery and YME1 complex maintains mitochondrial proteostasis and integrity

Kumar, A.; D'Silva, P.

10.1101/2022.02.03.478940 — cell biology — Posted on 2022-02-03

3314 Dynamically regulated Focal adhesions coordinate endothelial cell remodelling in developing vasculature

Chau, T. C.-Y.; Yordanov, T. E.; da Silva, J. A.; Patterson, S.; Yap, A. S.; Hogan, B. M.; Lagendijk, A. K.

10.1101/2022.02.01.478747 — cell biology — Posted on 2022-02-03

3315 Augmented glucose dependency of autoreactive B cells provides a treatment target forlupus

Wilson, J. J.; Wei, J.; Daamen, A. R.; Sears, J. D.; Bechtel, E.; Mayberry, C. L.; Stafford, G. A.; Bechtold, L.; Grammer, A. C.; Lipsky, P. E.; Roopenian, D. C.; Chang, C.-H.

10.1101/2022.02.01.475510 — immunology — Posted on 2022-02-03

3316 Cooperativity and folding kinetics in a multi-domain protein with interwoven chain topology

Liu, Z.; Thirumalai, D.

10.1101/2022.02.02.478901 — biophysics — Posted on 2022-02-03

3317 Binding of His-tagged fluorophores to lipid bilayers and giant vesicles

Pramanik, S.; Steinkuehler, J.; Dimova, R.; Spatz, J.; Lipowsky, R.

10.1101/2022.02.01.478643 — biophysics — Posted on 2022-02-03

3318 Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

Kar, M.; Dar, F.; Welsh, T. J.; Vogel, L.; Kuhnemuth, R.; Majumdar, A.; Krainer, G.; Franzmann, T. M.; Alberti, S.; Seidel, C. A. M.; Hyman, A. A.; Pappu, R. V.

10.1101/2022.02.03.478969 — biophysics — Posted on 2022-02-03

3319 A quiescent resident progenitor pool is the central organizer of tendon healing

Grinstein, M.; Tsai, S.; Montoro, D.; Dingwall, H.; Zou, K.; Sade-Feldman, M.; Tanaka, M.; Capellini, T. D.; Rajagopal, J.; Galloway, J. L.

10.1101/2022.02.02.478533 — cell biology — Posted on 2022-02-03

3320 Molecular mechanics underlying flat-to-round membrane budding in live secretory cells

Shin, W.; Zucker, B.; Kundu, N.; Lee, S. H.; Shi, B.; Guo, X.; Chan, C. Y.; Harrison, J. T.; Turechek, J. M.; Hinshaw, J. E.; Kozlov, M.; Wu, L.-G.

10.1101/2022.02.02.478826 — cell biology — Posted on 2022-02-03

3321 Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes

Kaserman, J.; Werder, R. B.; Wang, F.; Matte, T.; Higgins, M. I.; Dodge, M.; Lindstrom-Vautrin, J.; Hinds, A.; Bullitt, E.; Caballero, I.; Shi, X.; Gerszten, R. E.; Brunetti-Pierri, N.; Liesa, M.; Villacorta-Martin, C.; Hollenberg, A. N.; Kotton, D. N.; Wilson, A. A.

10.1101/2022.02.01.478663 — cell biology — Posted on 2022-02-03

3322 Distinct silencer states determine epigenetic states of heterochromatin

Saxton, D. S.; Rine, J.

10.1101/2022.02.01.478725 — cell biology — Posted on 2022-02-03

3323 Fish oil Nano-emulsion Kills Macrophage: Ferroptosis and Autophagy Triggered by Catalase-catalysed Superoxide Eruption

Gao, G.; Zhou, J.; Wang, H.; Ke, L.; Zhou, J.; Ding, Y.; Ding, W.; Zhang, S.; Rao, P.

10.1101/2022.02.02.478786 — cell biology — Posted on 2022-02-03

3324 Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending

Moussa, H. Y. A.; Shin, K. C.; Tong, Y.; Kim, S. J.; Ryu, J.-K.; Mansour, S.; Park, Y.

10.1101/2022.02.03.478933 — neuroscience — Posted on 2022-02-03

3325 Oxytocin promotes social grooming in bonobos

Brooks, J.; Kano, F.; Yeow, H.; Morimura, N.; Yamamoto, S.

10.1101/2021.11.30.468796 — animal behavior and cognition — Posted on 2022-02-03

3326 Feline Papillomavirus Isolate P20 Assembled from Metagenomic Data Isolated from the Human Skin of a House Cat Owner

Graham, E. H.; Adamowicz, M. S.; Angeletti, P.; Clarke, J.; Fernando, S.; Herr, J. R.

10.1101/2021.11.01.466825 — microbiology — Posted on 2022-02-03

3327 SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology

Shen, W.-B.; Logue, J.; Yang, P.; Baracco, L.; Elahi, M.; Reece, E. A.; Wang, B.; Li, L.; Blanchard, T.; Han, Z.; Frieman, M.; Rissman, R. A.; Yang, P.

10.1101/2022.01.31.478476 — neuroscience — Posted on 2022-02-03

3328 Recruitment of transcriptional effectors by Cas9 creates cis regulatory elements and demonstrates distance-dependent transcriptional regulation

Boulos, J.; Ehrlich, I.; Avidan, N.; Shkedi, O.; Haimovich-Caspi, L.; Kaplan, N.; Kehat, I.

10.1101/2022.02.03.478957 — genomics — Posted on 2022-02-03

3329 Minilungs from hESCs to study the interaction of Streptococcus pneumoniae with the respiratory tract

Zambrano, A.; Gonzalez-Camacho, F.; Rossi, S. A.; Sempere, J.; de Lucas, M. P.; Rojas-Cabaneros, J. M.; Taborda, C. P.; Zaragoza, O.; Yuste, J.

10.1101/2022.02.01.478764 — microbiology — Posted on 2022-02-03

3330 Nutrient gradients mediate creation of highly resistant layers in structured microbial populations during antibiotic exposures

Stevanovic, M.; Boukéké-Lesplulier, T.; Hupe, L.; Hasty, J.; Bittihn, P.; Schultz, D.

10.1101/2022.02.02.478895 — microbiology — Posted on 2022-02-03

3331 Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

Hawman, D. W.; Meade-White, K.; Clancy, C.; Archer, J.; Hinkley, T.; Leventhal, S.; Rao, D.; Stamper, A.; Lewis, M.; Rosenke, R.; Krieger, K.; Randall, S.; Khandhar, A. P.; Hao, L.; Hsiang, T.-Y.; Greninger, A. L.; Gale, M.; Berglund, P.; Fuller, D. H.; Rosenke, K.; Feldmann, H.; Erasmus, J.

10.1101/2022.01.31.478520 — microbiology — Posted on 2022-02-03

3332 RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

Burke, J. M.; Ripin, N.; Ferretti, M. B.; St Clair, L. A.; Worden-Sapper, E. R.; Sawyer, S. L.; Perera, R.; Lynch, K. W.; Parker, R.

10.1101/2022.01.28.478180 — immunology — Posted on 2022-02-03

3333 CACNB4 overexpression decreases dendritic spine density in sex-specific manner

Parker, E. M.; Kindja, N. L.; DeGiosio, R. A.; Salisbury, R. B.; Krivinko, J. M.; Cheetham, C. E. J.; MacDonald, M. L.; Sweet, R.

10.1101/2022.02.02.478824 — neuroscience — Posted on 2022-02-03

3334 Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)

Ortega-Gasco, A.; Parcerisas, A.; Hino, K.; Herranz-Perez, V.; Ulloa, F.; Elias-Tersa, A.; Bosch, M.; Garcia-Verdugo, J. M.; Simo, S.; Pujadas, L.; Soriano, E.

10.1101/2022.02.03.478938 — neuroscience — Posted on 2022-02-03

3335 Synthetic genetic circuits enable reprogramming of plant roots

Brophy, J. A. N.; Magallon, K. J.; Kniazev, K.; Dinneny, J. R.

10.1101/2022.02.02.478917 — synthetic biology — Posted on 2022-02-03

3336 High temperature limits leaf size via direct control of cell cycle by coordinated functions of PIF4 and TCP4

Saini, K.; Dwivedi, A.; Ranjan, A.

10.1101/2022.02.02.478810 — plant biology — Posted on 2022-02-03

3337 Knock-out of CmNAC-NOR affects melon climacteric fruit ripening

Liu, B.; Domingo, M. S.; Mayobre, C.; Martin-Hernandez, A. M.; Pujol, M.; Garcia-Mas, J.

10.1101/2022.02.02.478821 — plant biology — Posted on 2022-02-03

3338 Survival Genie, a web platform for survival analysis across pediatric and adult cancers.

Dwivedi, B.; Mumme, H.; Satpathy, S.; Bhasin, S. S.; Bhasin, M.

10.1101/2021.09.28.462224 — cancer biology — Posted on 2022-02-03

3339 SRSF1 as a novel interacting partner for IFITM1/3 unravels the emergent role of IFITM1/3 mediating protein expression

Kote, S.; Gomez-Herranz, M.; Faktor, J.; Yebenes Mayordomo, M.; Pilch, M.; Hernychova, L.; Ball, K. L.; Vojtesek, B.; Hupp, T.

10.1101/2022.02.02.478792 — cancer biology — Posted on 2022-02-03

3340 Sentinel Cards Provide Practical SARS-CoV-2 Monitoring in School Settings

Cantu, V. J.; Sanders, K.; Belda-Ferre, P.; Salido, R. A.; Tsai, R.; Austin, B.; Jordan, W.; Asudani, M.; Walster, A.; Magallanes, C. G.; Valentine, H. D.; Majnoonian, A.; Wijaya, C.; Omaleki, V.; Aigner, S.; Baer, N. A.; Betty, M.; Castro-Martinez, A.; Cheung, W.; De Hoff, P.; Eisner, E.; Hakim, A.; Lastrella, A. L.; Lawrence, E. S.; Ngo, T. T.; Ostrander, R. T.; Plascencia, A.; Sathe, S.; Smoot, E. W.; Carlin, A. F.; Yeo, G. W.; Laurent, L. C.; Manlutac, A. L.; Fielding-Miller, R.; Knight, R.

10.1101/2022.02.01.478759 — bioinformatics — Posted on 2022-02-03

3341 Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

Ermler, U.; Kayastha, K.; Katsyv, A.; Himmrichs, C.; Welsch, S.; Schuller, J. M.; Müller, V.

10.1101/2022.02.02.478877 — biochemistry — Posted on 2022-02-03

3342 Behavioural analysis of loss of function zebrafish supports baz1b as master regulator of domestication

Torres-Perez, J. V.; Anagianni, S.; Mech, A. M.; Havelange, W.; Garcia-Gonzalez, J.; Fraser, S. E.; Vallortigara, G.; Brennan, C. H.

10.1101/2022.02.02.478842 — animal behavior and cognition — Posted on 2022-02-03

3343 Reduced reproductive success is associated with selective constraint on human genes

Gardner, E. J.; Neville, M. D.; Samocha, K. E.; Barclay, K.; Kolk, M.; Niemi, M. E.; Kirov, G.; Martin, H. C.; Hurles, M. E.

10.1101/2020.05.26.116111 — genetics — Posted on 2022-02-03

3344 Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Duan, X.; Norris, D. M.; Humphrey, S. J.; Yang, P.; Cooke, K. C.; Bultitude, W. P.; Parker, B. L.; Conway, O. J.; Burchfield, J. G.; Krycer, J. R.; Brodsky, F. M.; James, D. E.; Fazakerley, D. J.

10.1101/2020.12.07.415257 — cell biology — Posted on 2022-02-03

3345 Evidence for close molecular proximity between reverting and undifferentiated cells

Zreika, S.; Fourneaux, C.; Vallin, E.; Modolo, L.; Seraphin, R.; Moussy, A.; Ventre, E.; Bouvier, M.; Ozier-Lafontaine, A.; Bonnaffoux, A.; Picard, F.; Gandrillon, O.; Gonin-Giraud, S.

10.1101/2022.02.01.478637 — cell biology — Posted on 2022-02-03

3346 Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets

Boekell, K. L.; Brown, B. J.; Talbot, B. E.; Schlondorff, J. S.

10.1101/2022.02.01.478727 — cell biology — Posted on 2022-02-03

3347 Wall teichoic acids facilitate the release of toxins from the surface of Staphylococcus aureus.

Brignoli, T.; Douglas, E. J.; Duggan, S.; Fagunloye, O. G.; Adhikari, R. P.; Aman, J.; Massey, R. C.

10.1101/2022.01.31.478600 — microbiology — Posted on 2022-02-03

3348 InvL, an invasin-like adhesin, is a type II secretion system substrate required for Acinetobacter baumannii uropathogenesis.

Jackson-Litteken, C. D.; Di Venanzio, G.; Le, N.-H.; Scott, N. E.; Djahanschiri, B.; Distel, J.; Pardue, E. J.; Ebersberger, I.; Feldman, M. F.

10.1101/2022.02.01.478765 — microbiology — Posted on 2022-02-03

3349 6S RNA-dependent antibiotic susceptibility

Esberard, M.; Hallier, M.; Liu, W.; Morvan, C.; Bossi, L.; Figueroa-Bossi, N.; Felden, B.; Bouloc, P.

10.1101/2022.01.31.478597 — microbiology — Posted on 2022-02-03

3350 Decomposing the role of alpha oscillations during brain maturation

Troendle, M.; Popov, T.; Dziemian, S.; Langer, N.

10.1101/2020.11.06.370882 — neuroscience — Posted on 2022-02-03

3351 Mind blanking is a distinct mental state linked to a recurrent brain profile of globally positive connectivity during ongoing mentation

Mortaheb, S.; Van Calster, L.; Raimondo, F.; Klados, M. A.; Boulakis, P. A.; Georgoula, K.; Majerus, S.; Van De Ville, D.; Demertzi, A.

10.1101/2021.05.10.443428 — neuroscience — Posted on 2022-02-03

3352 Presenilin and APP regulate synaptic kainate receptors

Barthet, G.; Moreira-de-Sa, A.; Zhang, P.; Castanheira, J.; Gorlewicz, A.; Mulle, C.

10.1101/2022.02.03.478926 — neuroscience — Posted on 2022-02-03

3353 PAX6 LIMITS THE COMPETENCE OF DEVELOPING CEREBRAL CORTICAL CELLS

Manuel, M.; Tan, K. B.; Kozic, Z.; Molinek, M.; Marcos, T. S.; Razak, M. F. A.; Dobolyi, D.; Dobie, R.; Henderson, B.; Hendserson, N.; Chan, W. K.; Daw, M.; Mason, J.; Price, D. J.

10.1101/2022.02.03.478927 — neuroscience — Posted on 2022-02-03

3354 The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing

Ghram, M.; Morris, G.; Culjkovic-Kraljacic, B.; Mars, J. C.; Gendron, P.; Skrabanek, L.; Revuelta, M. V.; Cerchietti, L.; Guzman, M.; Borden, K.

10.1101/2021.12.07.471666 — cancer biology — Posted on 2022-02-03

3355 Lossless Indexing with Counting de Bruijn Graphs

Karasikov, M.; Mustafa, H.; Rätsch, G.; Kahles, A.

10.1101/2021.11.09.467907 — bioinformatics — Posted on 2022-02-03

3356 Electrocardiogram feature extraction and interval measurements using optimal representative cycles from persistent homology

Dlugas, H.

10.1101/2022.02.01.478609 — bioinformatics — Posted on 2022-02-03

3357 Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells.

Lee, S. h.; Hao, Y.; Gui, T.; Dotti, G.; Savoldo, B.; Zou, F.; Kafri, T.

10.1101/2022.02.01.478686 — microbiology — Posted on 2022-02-03

3358 Introducing Conflict Resolution and Negotiation Training into a Biomedical Sciences Graduate Curriculum

Schaller, M.; Gatesman-Ammer, A.

10.1101/2021.04.05.438459 — scientific communication and education — Posted on 2022-02-03

3359 Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening

Jahed, Z.; Yang, Y.; Tsai, C.-T.; Foster, E. P.; McGuire, A. F.; Yang, H.; Liu, A.; Forro, C.; Yan, Z.; Jiang, X.; Zhao, M.-T.; Zheng, W.; Li, X.; Li, T.; Pawlosky, A.; Wu, J. C.; Cui, B.

10.1101/2021.09.28.462181 — bioengineering — Posted on 2022-02-03

3360 Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay

10.1101/2022.02.02.478908 — genetics — Posted on 2022-02-03

3361 Experimental sexual selection reveals rapid evolutionary divergence in sex-specific transcriptomes and their interactions following mating

Veltsos, P.; Porcelli, D.; Fang, Y.; Cossins, A. R.; Ritchie, M. G.; Snook, R. R.

10.1101/2021.01.29.428831 — evolutionary biology — Posted on 2022-02-03

3362 Sensory plasticity in a socially plastic bee

Boulton, R. A.; Field, J.

10.1101/2022.01.29.478030 — evolutionary biology — Posted on 2022-02-03

3363 Centrosomal Enrichment and Proteasomal Degradation of SYS-1/-β-catenin Requires the Microtubule Motor Dynein

Thompson, J. W.; Valdes Michel, M. F.; Phillips, B. T.

10.1101/2021.11.10.468136 — cell biology — Posted on 2022-02-03

3364 A surface morphometrics toolkit to quantify organellar membrane ultrastructure using cryo-electron tomography

Barad, B. A.; Medina, M.; Fuentes, D.; Wiseman, R. L.; Grotjahn, D. A.

10.1101/2022.01.23.477440 — cell biology — Posted on 2022-02-03

3365 Predicting the effects of multiple global change drivers onmicrobial communities remains challenging

Suleiman, M.; Daugaard, U.; Choffat, Y.; Zheng, X.; Petchey, O.

10.1101/2021.12.13.472339 — microbiology — Posted on 2022-02-03

3366 Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision

Ferko, K. M.; Blumenthal, A.; Martin, C. B.; Proklova, D.; Minos, A.; Saksida, L. M.; Bussey, T. J.; Khan, A. R.; Köhler, S.

10.1101/2021.01.21.427602 — neuroscience — Posted on 2022-02-03

3367 Different dopaminergic neurons signal absolute and relative aversive value in the Drosophila mushroom body.

Villar, M. E.; Pavao-Delgado, M.; Amigo, M.; Jacob, P. F.; Merabet, N.; Pinot, A.; Perry, S. A.; Waddell, S.; Perisse, E.

10.1101/2022.02.02.478814 — neuroscience — Posted on 2022-02-03

3368 Thunderstruck: The ACDC model of flexible sequences and rhythms in recurrent neural circuits

Calderon, C. B.; Verguts, T.; Frank, M. J.

10.1101/2021.04.07.438842 — neuroscience — Posted on 2022-02-03

3369 Dendritic compartmentalization of input-specific integration and plasticity rules across cortical development

Yaeger, C. E.; Vardalaki, D.; Brown, N. J.; Harnett, M. T.

10.1101/2022.02.02.478840 — neuroscience — Posted on 2022-02-03

3370 A metric and its derived protein network for evaluation of ortholog database inconsistency

Yang, W.; Ji, J.; Ling, S.; Fang, G.

10.1101/2022.01.24.477246 — bioinformatics — Posted on 2022-02-03

3371 Acoustic and vibrational signaling in true katydid Nesoecia nigrispina: three means of sound production in the one species

Korsunovskaya, O. S.; Zhantiev, R. D.

10.1101/2021.12.30.474575 — animal behavior and cognition — Posted on 2022-02-03

3372 Evidence of an additional wild contributor, Malus orientalis Uglitzk., to the genome of cultivated apple varieties in the Caucasus and Iran

Bina, H.; Yousefzadeh, H.; Venon, A.; Remoue, C.; Rousselet, A.; Falque, M.; Faramarzi, S.; Xilong, C.; Samanchina, J.; Gill, D.; Kabaeva, A.; GIRAUD, T.; Hossainpour, B.; Hamid, A.; Gabrielyan, I.; Nersesyan, A.; Cornille, A. A.

10.1101/2021.03.28.437401 — evolutionary biology — Posted on 2022-02-03

3373 Insect asynchronous flight requires neural circuit de-synchronization by electrical synapses

Huerkey, S.; Niemeyer, N.; Schleimer, J.-H.; Ryglewski, S.; Schreiber, S.; Duch, C.

10.1101/2022.02.02.478622 — neuroscience — Posted on 2022-02-02

3374 Bile Salts and N-Acetyl-D-Glucosamine induce transcription of the vieSAB Operon in Vibrio cholerae El Tor

Camilli, A.; Shull, L. M.

10.1101/2022.02.02.478790 — microbiology — Posted on 2022-02-02

3375 Exploring different virulent proteins of human respiratory syncytial virus for designing a novel epitope-based polyvalent vaccine: Immunoinformatics and molecular dynamics approaches

Moin, A. T.; Ullah, M. A.; Patil, R. B.; Faruqui, N. A.; Sarkar, B.; Araf, Y.; Das, S.; Uddin, K. M. K.; Hossain, M. S.; Miah, M. F.; Moni, M. A.; Chowdhury, D. U. S.; Islam, S.

10.1101/2022.02.02.478791 — immunology — Posted on 2022-02-02

3376 Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq

Wessels, H.-H.; Mendez-Mancilla, A.; Papalexi, E.; Mauck, W. M.; Lu, L.; Morris, J. A.; Mimitou, E. P.; Smibert, P.; Sanjana, N. E.; Satija, R.

10.1101/2022.02.02.478894 — genomics — Posted on 2022-02-02

3377 Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages

Oliveira, G.; Vogels, C. B. F.; Zolfaghari, A.; Saraf, S.; Klitting, R.; Weger-Lucarelli, J.; Ontiveros, C. O.; Agarwal, R.; Leon, K. P.; Tsetsarkin, K. A.; Harris, E.; Ebel, G. D.; Wohl, S.; Grubaugh, N. D.; Andersen, K. G.

10.1101/2022.02.01.478673 — evolutionary biology — Posted on 2022-02-02

3378 An ancient endogenous DNA virus in the human genome

Nino Barreat, J. G.; Katzourakis, A.

10.1101/2022.02.01.478760 — evolutionary biology — Posted on 2022-02-02

3379 Breasi-CRISPR: an efficient genome editing method to interrogate protein localization and protein-protein interactions in the embryonic mouse cortex

Meyerink, B. L.; KC, P.; Tiwari, N. K.; Kittock, C. M.; Klein, A.; Evans, C. M.; Pilaz, L.-J.

10.1101/2022.02.02.478837 — developmental biology — Posted on 2022-02-02

3380 Determining the targeting specificity of the selective peroxisomal targeting factor Pex9

Yifrach, E.; Ruowitz, M.; Cruz Zaragoza, L. D.; Tirosh, A.; Gazi, Z.; Peleg, Y.; Kunze, M.; Eisenstein, M.; Schliebs, W.; Schuldiner, M.; Erdmann, R.; Zalckvar, E.

10.1101/2022.02.02.478779 — cell biology — Posted on 2022-02-02

3381 Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity

Bersten, D. C.; Sullivan, A. E.; McDougal, D.; Breen, J.; Fitzsimmons, R. L.; Muscat, G. E.; Pederson, S.; Bruning, J. B.; Fan, C.-M. M.; Thomas, P. Q.; Russell, D. L.; Peet, D. J.; Whitelaw, M. L.

10.1101/2022.02.01.475276 — molecular biology — Posted on 2022-02-02

3382 Expanded transcriptomic analysis of human hepatic stellate cells links novel coding and noncoding products to human liver fibrosis

Mahpour, A.; Mullen, A. C.

10.1101/2022.02.01.478715 — molecular biology — Posted on 2022-02-02

3383 Ddp1 cooperates with Ppx1 to counter a stress response initiated by non-vacuolar polyphosphate

McCarthy, L.; Abramchuk, I.; Wafy, G.; Denoncourt, A.; Lavallee-Adam, M.; Downey, M.

10.1101/2022.02.02.478728 — molecular biology — Posted on 2022-02-02

3384 Structural basis of streptomycin off-target binding to human mitoribosome

Itoh, Y.; Khawaja, A.; Singh, V.; Naschberger, A.; Rorbach, J.; Amunts, A.

10.1101/2022.02.02.478878 — molecular biology — Posted on 2022-02-02

3385 Intracellular flow cytometry complements RT-qPCR detection of circulating SARS-CoV-2 variants of concern

Vanhulle, E.; Provinciael, B.; Stroobants, J.; Camps, A.; Maes, P.; Vermeire, K.

10.1101/2022.02.02.478775 — microbiology — Posted on 2022-02-02

3386 Microbiomes of the bloom-forming alga, Phaeocystis globosa, are stable, consistently recruited communities with symbiotic and opportunistic modes

Brisbin, M.; Mitarai, S.; Saito, M.; Alexander, H.

10.1101/2022.02.02.478862 — microbiology — Posted on 2022-02-02

3387 Class II UvrA protein Ecm16 requires ATPase activity to render resistance against echinomycin

Erlandson, A.; Gade, P.; Kim, C.-Y.; Mera, P. E.

10.1101/2022.02.02.478902 — microbiology — Posted on 2022-02-02

3388 Scale of analysis drives the observed ratio of spatial to non-spatial variance in microbial water quality: insights from two decades of citizen science data

Weller, D. L.; Weller, D. E.; Strawn, L. K.; Love, T. M. T.

10.1101/2022.02.01.478743 — microbiology — Posted on 2022-02-02

3389 Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

Lachen-Montes, M.; Mendizuri, N.; Ausin, K.; Echaide, M.; Blanco, E.; Chocarro, L.; De Toro, M.; Escors, D.; Fernandez-Irigoyen, J.; Kochan, G.; Santamaria, E.

10.1101/2022.02.01.478724 — systems biology — Posted on 2022-02-02

3390 Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner

Friske, M. M.; Giannone, F.; Senger, M.; Seitz, R.; Hansson, A. C.; Spanagel, R.

10.1101/2022.02.01.478685 — pharmacology and toxicology — Posted on 2022-02-02

3391 A new fold in TANGO1 evolved from SH3 domains for the export of bulky cargos

Arnolds, O.; Stoll, R.

10.1101/2022.02.02.478833 — biophysics — Posted on 2022-02-02

3392 Patterns of Volatility Across the Spike Protein Accurately Predict the Emergence of Mutations within SARS-CoV-2 Lineages

Rojas Chavez, R. A.; Fili, M.; Han, C.; Rahman, S. A.; Bicar, I. G. L.; Hu, G.; Das, J.; Brown, G. D.; Haim, H.

10.1101/2022.02.01.478697 — bioinformatics — Posted on 2022-02-02

3393 Design and development of potent h-ACE2 derived peptide mimetics in SARS-CoV-2 Omicron variant therapeutics

Paul, S. M. L.; Nadendla, S.; Sobhia, E. M.

10.1101/2022.02.01.478632 — bioinformatics — Posted on 2022-02-02

3394 Chemically modified dsRNA induces RNAi effects in insects in vitro and in vivo: A potential new tool for improving RNA-based plant protection

Howard, J. D.; Beghyn, M.; Dewulf, N.; De Vos, Y.; Philips, A.; Portwood, D.; Kilby, P. M.; Oliver, D.; Maddelein, W.; Brown, S.; Dickman, M. J.

10.1101/2022.02.02.478785 — bioengineering — Posted on 2022-02-02

3395 Effects of calorie restriction on reactive oxygen species production by mitochondrial reverse electron transport, mitochondrial permeability transition pore, and beta-adrenergic stimulation during cardiac hypertrophy

Lucas, A. M. B.; Palacio, P. B.; Cunha, P. L. O.; Facundo, H. T.

10.1101/2022.02.02.478846 — biochemistry — Posted on 2022-02-02

3396 A natural fusion of flavodiiron, rubredoxin, and NADH:rubredoxin oxidoreductase domains is the highly efficient water-forming oxidase of T. vaginalis

Abdulaziz, E. N.; Bell, T. A.; Rashid, B.; Heacock, M. L.; Skinner, O. S.; Yaseen, M. A.; Chao, L. H.; Mootha, V. K.; Pierik, A. J.; Cracan, V.

10.1101/2022.02.02.478753 — biochemistry — Posted on 2022-02-02

3397 RNase H-based analysis of synthetic mRNA 5-prime cap incorporation

Chan, S.-H.; Whipple, J. M.; Dai, N.; Kelley, T. M.; Withers, K.; Tzertzinis, G.; Correa, I. R.; Robb, G. B.

10.1101/2022.02.02.478748 — biochemistry — Posted on 2022-02-02

3398 Cyclization studies of Japanese encephalitis virus non-coding RNA terminal regions.

Mrozowich, T.; Park, S. M.; Waldl, M.; Henrickson, A.; Nelson, C. R.; Demeler, B.; Hofacker, I. L.; Wolfinger, M. T.; Patel, T. R.

10.1101/2022.02.01.478553 — biochemistry — Posted on 2022-02-02

3399 Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

d'Amico, E.; Ud Din Ahmad, M.; Cmentowski, V.; Girbig, M.; Mueller, F.; Wohlgemuth, S.; Brockmeyer, A.; Maffini, S.; Janning, P.; Vetter, I. R.; Carter, A. P.; Perrakis, A.; Musacchio, A.

10.1101/2022.02.02.478874 — biochemistry — Posted on 2022-02-02

3400 USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

Karlowitz, R.; Stanifer, M. L.; Roedig, J.; Andrieux, G.; Bojkova, D.; Smith, S.; Kowald, L.; Schubert, R.; Boerries, M.; Cinatl, J.; Boulant, S.; van Wijk, S. J.

10.1101/2022.02.01.478628 — cell biology — Posted on 2022-02-02

3401 Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

Xia, B.; Wang, Y.; Pan, X.; Cheng, X.; Ji, H.; Zuo, X.; Li, J.; Gao, Z.

10.1101/2022.02.01.478647 — microbiology — Posted on 2022-02-02

3402 Antimicrobial resistance and virulence characteristics of Klebsiella pneumoniae isolates in Kenya

Muraya, A. W.; Kyany'a, C.; Kiyaga, S.; Smith, H. J.; Kibet, C.; Martin, M. J.; Kimani, J.; Musila, L.

10.1101/2022.02.01.478614 — microbiology — Posted on 2022-02-02

3403 The new archaeal order Lutiacidiplasmatales reveals convergent evolution in Thermoplasmatota

Sheridan, P. O.; Meng, Y.; Williams, T. A.; Gubry-Rangin, C.

10.1101/2022.02.02.478836 — microbiology — Posted on 2022-02-02

3404 Imaging minimal bacteria at the nanoscale: a reliable and versatile process to perform Single Molecule Localization Microscopy in mycoplasmas

Rideau, F.; Villa, A.; Belzanne, P.; Verdier, E.; Hosy, E.; Arfi, Y.

10.1101/2022.02.02.478797 — microbiology — Posted on 2022-02-02

3405 Stability and volatility shape the gut bacteriome and mycobiome dynamics in a pig model

Feehan, B.; Ran, Q.; Dorman, V.; Rumback, K.; Pogranichniy, S.; Ward, K.; Goodband, R.; Niederwerder, M. C.; Summers, K. L.; Lee, S. T. M.

10.1101/2022.02.02.478893 — microbiology — Posted on 2022-02-02

3406 Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

Spring, J.; Lara, S.; Khan, A. A.; O'Grady, K.; Wilks, J.; Gurbuxani, S.; Erickson, S.; Fischbach, M.; Jacobson, A.; Chervonsky, A.; Golovkina, T.

10.1101/2022.02.02.478820 — microbiology — Posted on 2022-02-02

3407 The impact of multigenerational high-fat diet feeding on the gut microbiome and host metabolism

Wibowo, M. C.; Yang, Z.; Chavkin, T. A.; Nguyen, B.; Pham, L.-D.; Huang, T. L.; Lynes, M. D.; Tseng, Y.-H.; Kostic, A. D.

10.1101/2022.02.01.478488 — microbiology — Posted on 2022-02-02

3408 CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation

Sung, P.-S.; Yang, S.-P.; Peng, Y.-C.; Sun, C.-P.; Tao, M.-H.; Hsieh, S.-L.

10.1101/2022.02.01.478701 — immunology — Posted on 2022-02-02

3409 A Split-GAL4 screen identifies novel sleep-promoting neurons in the Ventral Nerve Cord of Drosophila

Jones, J.; Holder, B.; Eiken, K.; Vogt, A.; Velarde, A.; Elder, A.; McEllin, J.; Dissel, S.

10.1101/2022.02.02.478882 — neuroscience — Posted on 2022-02-02

3410 Identifying inputs to visual projection neurons in Drosophila lobula by analyzing connectomic data

Tanaka, R.; Clark, D. A.

10.1101/2022.02.02.478876 — neuroscience — Posted on 2022-02-02

3411 Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer

Brown, M. S.; Abdollahi, B.; Wilkins, O. M.; Lu, H.; Chakraborty, P.; Ognjenovic, N. B.; Muller, K. E.; Jolly, M. K.; Christensen, B.; Hassanpour, S.; Pattabiraman, D. R.

10.1101/2021.03.17.434993 — cancer biology — Posted on 2022-02-02

3412 A rapid ecological assessment for necrophagous flies (Diptera, Calyptratae) in a mosaic landscape of the Colombian Andes

Amat, E.; Medina, C. A.

10.1101/2020.07.24.220491 — ecology — Posted on 2022-02-02

3413 Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability

Hirose, R.; Itoh, Y.; Ikegaya, H.; Miyazaki, H.; Watanabe, N.; Yoshida, T.; Bandou, R.; Daidoji, T.; Nakaya, T.

10.1101/2022.01.18.476607 — microbiology — Posted on 2022-02-02

3414 Modelling and assessing additional transmission routes for porcine reproductive and respiratory syndrome virus: vehicle movements and feed ingredients

Galvis, J. A.; Corzo, C.; Machado, G.

10.1101/2021.07.26.453902 — ecology — Posted on 2022-02-02

3415 Genetic mapping of flowering time and plant height in a maize Stiff Stalk MAGIC population

Michel, K. J.; Lima, D. C.; Hundley, H.; Singan, V.; Yoshinaga, Y.; Daum, C.; Barry, K.; Broman, K. W.; Buell, C. R.; de Leon, N.; Kaeppler, S. M.

10.1101/2022.01.31.478539 — genomics — Posted on 2022-02-02

3416 Transmission Dynamics of Human Herpesviruses and Other Blood DNA Viruses from Whole Genome Sequences of Families

Chrisman, B.; He, C.; Jung, J.-Y.; Stockham, N.; Paskov, K.; Washington, P.; Wall, D. P.

10.1101/2022.01.31.478555 — genomics — Posted on 2022-02-02

3417 Rare and population-specific functional variation across pig lines

Ros-Freixedes, R.; Valente, B. D.; Chen, C.-Y.; Herring, W. O.; Gorjanc, G.; Hickey, J. M.; Johnsson, M.

10.1101/2022.02.01.478603 — genomics — Posted on 2022-02-02

3418 Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

Xiao, S.; Zhong, N.; Yang, Q.; Li, A.; Tong, W.; Zhang, Y.; Yao, G.; Wang, S.; Liu, J.; Liu, Z.

10.1101/2022.02.01.478641 — cell biology — Posted on 2022-02-02

3419 Detection and Interspecies Comparison of SARS-CoV-2 Delta Variant (AY.3) in Feces from a Domestic Cat and Human Samples

Lenz, O. C.; Marques, A. D.; Kelly, B. J.; Rodino, K. G.; Cole, S. D.; Perera, R. A.; Weiss, S. R.; Bushman, F. D.; Lennon, E. M.

10.1101/2022.01.31.478506 — microbiology — Posted on 2022-02-02

3420 Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

Atalis, A. M.; Keenum, M. C.; Pandey, B.; Beach, A.; Pradhan, P.; Vantucci, C. E.; Jain, R.; Hosten, J.; Smith, C.; Kramer, L. L.; Jimenez, A. C.; Armenta-Ochoa, M. A.; Frey, D. A.; Roy, K.

10.1101/2022.01.31.478507 — immunology — Posted on 2022-02-02

3421 Neural network of superiority illusion predicts the level of dopamine in striatum

Yahata, N.; Isato, A.; Kimura, Y.; Yokokawa, K.; Zhang, M.-R.; Ito, H.; Suhara, T.; Higuchi, M.; Yamada, M.

10.1101/2022.02.01.478593 — neuroscience — Posted on 2022-02-02

3422 Capturing early human memory consolidation utilizing the higher functional specificity of 7T compared to 3T-fMRI

Kreitz, S.; Mennecke, A.; Konerth, L.; Roesch, J.; Nagel, A. M.; Laun, F. B.; Uder, M.; Doerfler, A.; Hess, A.

10.1101/2022.02.01.478615 — neuroscience — Posted on 2022-02-02

3423 Proteomics and Functional Analysis Revealed TaGSTU6/TaCBSX3 Enhances Wheat Resistance to Powdery Mildew

Wang, Q.; Wang, B.; Li, Q.; Guo, J.; Peng, C.; Jin, P.; Guo, J.; Ying, G. M.

10.1101/2022.01.31.478538 — pathology — Posted on 2022-02-02

3424 Toward an atomistic model of SARS-CoV-2

Wang, D.; Li, J.; Wang, L.; Cao, Y.; Li, S.; Song, C.

10.1101/2022.01.31.478415 — biophysics — Posted on 2022-02-02

3425 Electrocardiogram feature extraction and interval measurements using optimal representative cycles from persistent homology

Dlugas, H.

10.1101/2022.02.01.478609 — bioinformatics — Posted on 2022-02-02

3426 ReadBouncer: Precise and Scalable Adaptive Sampling for Nanopore Sequencing

Ulrich, J.-U.; Lutfi, A.; Rutzen, K.; Renard, B. Y.

10.1101/2022.02.01.478636 — bioinformatics — Posted on 2022-02-02

3427 mSigHdp: hierarchical Dirichlet process mixture modeling for mutational signature discovery

Liu, M.; Wu, Y.; Jiang, N.; Boot, A.; Rozen, S. G.

10.1101/2022.01.31.478587 — bioinformatics — Posted on 2022-02-02

3428 Metabolic predictors of phenotypic traits can replace and complement measured clinical variables in transcriptome-wide association studies

Niehues, A.; Bizzarri, D.; Reinders, M. J. T.; Slagboom, P. E.; van Gool, A. J.; van den Akker, E. B.; Hoen, P.-B. t.

10.1101/2022.02.01.478610 — bioinformatics — Posted on 2022-02-02

3429 Clinical Time-to-Event Prediction Enhanced by Incorporating Compatible Related Outcomes

Gao, Y.; Cui, Y.

10.1101/2022.01.31.478403 — bioinformatics — Posted on 2022-02-02

3430 Syllable-PBWT for space-efficient haplotype long-match query

Wang, V.; Naseri, A.; Zhang, S.; Zhi, D.

10.1101/2022.01.31.478234 — bioinformatics — Posted on 2022-02-02

3431 SleepMat: A New Behavioral Analysis Software Program for Sleep and Circadian Rhythms

Sisobhan, S.; Rosensweig, C.; Lear, B. C.; Allada, R.

10.1101/2022.01.31.478545 — bioinformatics — Posted on 2022-02-02

3432 ImmunoTyper-SR: A Novel Computational Approach for Genotyping Immunoglobulin Heavy Chain Variable Genes using Short Read Data

Ford, M.; Hari, A.; Rodriguez, O.; Xu, J.; Lack, J.; Oguz, C.; Zhang, Y.; Weber, S.; Magliocco, M.; Barnett, J.; Xirasagar, S.; Samuel, S.; Imberti, L.; Bonfanti, P.; Biondi, A.; Dalgard, C.; Chanock, S.; Rosen, L.; Holland, S.; Su, H.; Notarangelo, L.; Vishkin, U.; Watson, C.; Sahinalp, C.

10.1101/2022.01.31.478564 — bioinformatics — Posted on 2022-02-02

3433 Generative pretraining from large-scale transcriptomes: Implications for single-cell deciphering and clinical translation

Shen, H.; Shen, X.; Hu, J.; Liu, J.; Zhang, C.; Wu, D.; Feng, F.; Yang, M.; Li, Y.; Yang, Y.; Wang, W.; Zhang, Q.; Yang, J.; Chen, K.; Li, X.

10.1101/2022.01.31.478596 — bioinformatics — Posted on 2022-02-02

3434 3D printed bioreactor enabling the physiological culture and the study of pathological processes in large vessels.

Matos, R. S.; Maselli, D.; McVey, J. H.; Heiss, C.; Campagnolo, P.

10.1101/2022.02.01.477871 — bioengineering — Posted on 2022-02-02

3435 Rapid Carbon Dioxide Capture and Short-Term Biocompatible Sequestration in Aquatic Environments by Monoethanolamine Scrubbing within Calcium Alginate Gel

Ogundare, S. O.

10.1101/2022.01.31.478517 — bioengineering — Posted on 2022-02-02

3436 Deep Mendelian Randomization: Investigating the causal knowledge of genomic deep learning models

Malina, S.; Cizin, D.; Knowles, D. A.

10.1101/2022.02.01.478608 — genomics — Posted on 2022-02-02

3437 A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

Eccleston, R. C.; Manko, E.; Campino, S.; Clark, T. G.; Furnham, N.

10.1101/2022.01.25.477595 — evolutionary biology — Posted on 2022-02-02

3438 Fezf2 and Aire1 evolutionary trade-off in negative selection of T cells in the thymus

Mickael, M. E.

10.1101/2022.02.01.478624 — evolutionary biology — Posted on 2022-02-02

3439 Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing prediction in Klebsiella pneumoniae based on MALDI-TOF mass spectra

Guerrero-Lopez, A.; Sevilla-Salcedo, C.; Candela, A.; Hernandez-Garcia, M.; Cercenado, E.; Olmos, P. M.; Canton, R.; Munoz, P.; Gomez-Verdejo, V.; del Campo, R.; Rodriguez-Sanchez, B.

10.1101/2021.10.04.463058 — microbiology — Posted on 2022-02-02

3440 Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control

Riesenberg, B. P.; Hunt, E. G.; Tennant, M. D.; Hurst, K. E.; Andrews, A. M.; Leddy, L. R.; Neskey, D. M.; Hill, E. G.; Rivera, G. O. R.; Paulos, C. M.; Gao, P.; Thaxton, J. E.

10.1101/2022.01.31.478547 — immunology — Posted on 2022-02-02

3441 Micapipe: a pipeline for multimodal neuroimaging and connectome analysis

Rodriguez-Cruces, R.; Royer, J.; Herholz, P.; Lariviere, S.; Vos de Wael, R.; Paquola, C.; Benkarim, O.; Park, B.-y.; Degre-Pelletier, J.; Nelson, M.; DeKraker, J.; Tardif, C.; Poline, J.-B.; Concha, L.; Bernhardt, B.

10.1101/2022.01.31.478189 — neuroscience — Posted on 2022-02-02

3442 Human neural progenitors establish a diffusion barrier in the ER membrane during cell division

Bin Imtiaz, K.; Royall, L. N.; Jessberger, S.

10.1101/2022.02.02.478772 — neuroscience — Posted on 2022-02-02

3443 Autism in a dish: ES cell models of autism with copy number variations reveal cell-type-specific vulnerability

Nomura, J.; Amila, Z.; Kishimoto, K.; Mutsumine, H.; Fukatsu, K.; Nomura, Y.; Liu, X.; Nakai, N.; ES library team, ; Takahashi, E.; Kouno, T.; Shin, J. W.; Takumi, T.

10.1101/2022.02.02.478766 — neuroscience — Posted on 2022-02-02

3444 Metabolic switch in the aging astrocyte evidenced via integrative approach comprising network and transcriptome analyses

Acevedo, A.; Torres, F.; Kiwi, M.; Baeza-Lehnert, F.; Barros, L. F.; Lee-Liu, D.; Gonzalez-Billault, C.

10.1101/2022.01.31.478210 — neuroscience — Posted on 2022-02-02

3445 Cyclic, condition-independent activity in primary motor cortex predicts corrective movement behavior

Rouse, A. G.; Schieber, M. H.; Sarma, S. V.

10.1101/453746 — neuroscience — Posted on 2022-02-02

3446 JUN Regulation of Injury-induced Enhancers in Schwann Cells

Ramesh, R.; Manurung, Y.; Ma, K. H.; Blakely, T.; Won, S.; Wyatt, E.; Awatramani, R.; Svaren, J.

10.1101/2022.01.31.478565 — neuroscience — Posted on 2022-02-02

3447 Activity and state dependent modulation of salt taste behavior in Drosophila melanogaster

Kaushik, S.; Kumar, R.; Kumar, S.; Sanghi, S.; Kain, P.

10.1101/2022.02.01.478606 — neuroscience — Posted on 2022-02-02

3448 Different dopaminergic neurons signal absolute and relative aversive value in the Drosophila mushroom body.

Perisse, E.; Villar, M. E.; Pavao-Delgado, M.; Amigo, M.; Jacob, P. F.; Merabet, N.; Pinot, A.; Perry, S. A.; Waddell, S.

10.1101/2022.02.02.478814 — neuroscience — Posted on 2022-02-02

3449 Statistical learning of successor representations is related to on-task replay

Wittkuhn, L.; Krippner, L. M.; Schuck, N. W.

10.1101/2022.02.02.478787 — neuroscience — Posted on 2022-02-02

3450 Robust deep learning object recognition models rely on low frequency information in natural images

Li, Z.; Caro, J. O.; Rusak, E.; Brendel, W.; Bethge, M.; Anselmi, F.; Patel, A. B.; Tolias, A.; Pitkow, X.

10.1101/2022.01.31.478509 — neuroscience — Posted on 2022-02-02

3451 Soil amendments and suppresssion of Phytophthora root rot in avocado (Persea indica)

Farooq, Q. U. A.; McComb, J.; Hardy, G. S. J.; Burgess, T. I.

10.1101/2022.01.31.478582 — plant biology — Posted on 2022-02-02

3452 Stabilizing proteins through saturation suppressor mutagenesis.

Ahmed, S.; Manjunath, K.; Chattopadhyay, G.; Varadarajan, R.

10.1101/2021.08.07.455542 — biophysics — Posted on 2022-02-02

3453 Bias in miRNA enrichment analysis related to gene functional annotations

Zagganas, K.; Georgakilas, G. K.; Vergoulis, T.; Skiadopoulos, S.; Dalamagas, T.

10.1101/2021.08.16.456527 — bioinformatics — Posted on 2022-02-02

3454 Designing a Multi-Epitope Vaccine Candidate against Salmonella Typhi Using Immunoinformatics Approach

Sirajee, A. S.; Ahsan, S.

10.1101/2022.01.31.478495 — bioinformatics — Posted on 2022-02-02

3455 Identification of significant molecules and signaling pathways between 2D and 3D culture methods of renal cancer cells

Wang, M.; Guo, H.; Gu, H.; Zhang, M.

10.1101/2022.01.31.478529 — bioinformatics — Posted on 2022-02-02

3456 Evaluation of taxonomic profiling methods for long-read shotgun metagenomic sequencing datasets

Portik, D. M.; Brown, C. T.; Pierce-Ward, N. T.

10.1101/2022.01.31.478527 — bioinformatics — Posted on 2022-02-02

3457 The Human "Contaminome": Bacterial, Viral, and Computational Contamination in Whole Genome Sequences from 1,000 Families

Chrisman, B.; He, C.; Jung, J.-Y.; Stockham, N.; Washington, P.; Paskov, K.; Wall, D. P.

10.1101/2022.01.31.478554 — bioinformatics — Posted on 2022-02-02

3458 A New Classification Method Based on Dynamic Ensemble Selection and its Application to Predict Variance Patterns in HIV-1 Env

Fili, M.; Hu, G.; Han, C.; Kort, A.; Trettin, J.; Haim, H.

10.1101/2022.01.31.478521 — bioinformatics — Posted on 2022-02-02

3459 ClustAssess: tools for assessing the robustness of single-cell clustering

Shahsavari, A.; Munteanu, A.; Mohorianu, I.

10.1101/2022.01.31.478592 — bioinformatics — Posted on 2022-02-02

3460 NetMix2: Unifying network propagation andaltered subnetworks

Chitra, U.; Park, T. Y.; Raphael, B. J.

10.1101/2022.01.31.478575 — bioinformatics — Posted on 2022-02-02

3461 Surface engineering enhances the therapeutic potential of extracellular vesicles following acute myocardial infarction

Mentkowski, K. I.; Tarvirdizadeh, T.; Manzanero, C. A.; Eagler, L. A.; Lang, J. K.

10.1101/2022.01.31.478512 — bioengineering — Posted on 2022-02-02

3462 Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction

Yang, J.; Hirai, Y.; Imamura, S.; Tsuchiya, T.; Tabata, O.; Kamei, K.-i.

10.1101/2022.01.31.478467 — bioengineering — Posted on 2022-02-02

3463 Physiological stress responses to non-mimetic model brood parasite eggs: leukocyte profiles and heat-shock protein Hsp70 levels

Ruiz-Raya, F.; Abaurrea, T.; Vigo, R.; Soler, M.

10.1101/2022.01.31.478544 — animal behavior and cognition — Posted on 2022-02-02

3464 Transcription Factor-Centric Approach to Identify Non-Recurring Putative Regulatory Drivers in Cancer

Zhao, J.; Martin, V.; Gordan, R.

10.1101/2022.01.31.478493 — genomics — Posted on 2022-02-02

3465 A high-quality genome assembly and annotation of the European earwig Forficula auricularia.

Bhattarai, U. R.; Katuwal, M.; Poulin, R.; Gemmell, N. J.; Dowle, E.

10.1101/2022.01.31.478561 — genomics — Posted on 2022-02-02

3466 Expanded Analysis of Pigmentation Genetics in UK Biobank

Pairo-Castineira, E.; Cornelissen, J.; Rawlik, K.; Canela-Xandri, O.; Loftus, S. K.; Pavan, W. J.; Brown, K. M.; Tenesa, A.; Jackson, I. J.

10.1101/2022.01.30.478418 — genetics — Posted on 2022-02-02

3467 The extinction time under mutational meltdown

Lansch-Justen, L.; Cusseddu, D.; Schmitz, M. A.; Bank, C.

10.1101/2022.02.01.478601 — evolutionary biology — Posted on 2022-02-02

3468 Seasonal IVIG contains high infectivity neutralizing and hemagglutination inhibition activity against seasonal flu virus strains selected for vaccines (2020-22)

Diez, J.-M.; Casals, D.; Romero, C.; Gajardo, R.

10.1101/2022.01.31.478469 — immunology — Posted on 2022-02-02

3469 Embodiment of Supernumerary Robotic Limbs in Virtual Reality

Arai, K.; Saito, H.; Fukuoka, M.; Ueda, S.; Sugimoto, M.; Kitazaki, M.; Inami, M.

10.1101/2022.01.31.478373 — neuroscience — Posted on 2022-02-02

3470 A hardware system for real-time decoding of in-vivo calcium imaging data

Chen, Z.; Blair, G. J.; Guo, C.; Izquierdo, A.; Golshani, P.; Cong, J.; Aharoni, D.; Blair, H. T.

10.1101/2022.01.31.478424 — neuroscience — Posted on 2022-02-02

3471 Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain

Ose, T.; Autio, J. A.; Ohno, M.; Frey, S.; Uematsu, A.; Kawasaki, A.; Takeda, C.; Hori, Y.; Nishigori, K.; Nakako, T.; Yokoyama, C.; Nagata, H.; Yamamori, T.; Van Essen, D. C.; Glasser, M. F.; Watabe, H.; Hayashi, T.

10.1101/2022.01.31.478477 — neuroscience — Posted on 2022-02-02

3472 Generating spatiotemporal patterns of linearly polarised light at high frame rates for insect vision research

Supple, J. A.; Varennes-Phillit, L.; Gajjar-Reid, D.; Cerkvenik, U.; Belusic, G.; Krapp, H. G.

10.1101/2022.01.31.478537 — neuroscience — Posted on 2022-02-02

3473 GLMsingle: a toolbox for improving single-trial fMRI response estimates

Prince, J. S.; Charest, I.; Kurzawski, J. W.; Pyles, J. A.; Tarr, M. J.; Kay, K. N.

10.1101/2022.01.31.478431 — neuroscience — Posted on 2022-02-02

3474 Increased academic performance and prolonged career duration among Taiwanese academic faculty in ecology and evolutionary biology

Hsu, G.-C.; Lin, W.-J.; Sun, S.-J.

10.1101/2022.01.31.478501 — scientific communication and education — Posted on 2022-02-02

3475 Using Unassigned NMR Chemical Shifts to Model RNA Secondary Structure

Moudgal, N.; Arhin, G.; Frank, A. T.

10.1101/2022.01.30.478380 — biophysics — Posted on 2022-02-02

3476 Autosomal monoallelic genes are differentially regulated based on parental origin

Balasooriya, G. I.; Spector, D. L.

10.1101/2022.02.01.478691 — genetics — Posted on 2022-02-02

3477 Cilia stimulatory and antibacterial activities of bitter receptor agonist diphenhydramine: insights into potential complimentary strategies for CF nasal infections

Kuek, L. E.; McMahon, D. B.; Ma, R. Z.; Miller, Z. A.; Jolivert, J. F.; Adappa, N. D.; Palmer, J. N.; Lee, R. J.

10.1101/2022.01.31.478409 — physiology — Posted on 2022-02-02

3478 Ablation of SAMD1 in Mice Causes Failure of Angiogenesis, Embryonic Lethality

Campbell, B.; Engle, S.; Ozolins, T.; Bourassa, P.; Aiello, R.

10.1101/2022.01.11.473462 — developmental biology — Posted on 2022-02-02

3479 Temporal and spatial auxin responsive networks in maize primary roots

McReynolds, M. R.; Dash, L.; Montes, C.; Draves, M. A.; Lang, M. G.; Walley, J. W.; Kelley, D. R.

10.1101/2022.02.01.478706 — plant biology — Posted on 2022-02-02

3480 Tibial nerve stimulation increases vaginal blood perfusion and bone mineral density and yield load in ovariectomized rats

Xu, J. J.; Zimmerman, L.; Soriano, V.; Mentzelopoulos, G.; Kennedy, E.; Bottorff, E.; Stephan, C.; Kozloff, K.; Devlin, M. J.; Bruns, T. M.

10.1101/2021.12.03.469332 — physiology — Posted on 2022-02-02

3481 Nanomechanics combined with HDX reveal allosteric drug binding sites of CFTR NBD1

Padanyi, R.; Farkas, B.; Tordai, H.; Kiss, B.; Grubmuller, H.; Soya, N.; Lukacs, G.; Kellermayer, M.; Hegedus, T.

10.1101/2021.08.20.457065 — biophysics — Posted on 2022-02-02

3482 Rate-limiting transport of positive charges through the Sec-machinery is integral to the mechanism of protein transport

Allen, W. J.; Corey, R. A.; Watkins, D. W.; Oliveira, A. S. F.; Hards, K.; Cook, G. M.; Collinson, I.

10.1101/592543 — biochemistry — Posted on 2022-02-02

3483 The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator

Mitgau, J.; Franke, J.; Schinner, C.; Stephan, G.; Berndt, S.; Placantonakis, D. G.; Kalwa, H.; Spindler, V.; Wilde, C.; Liebscher, I.

10.1101/2021.09.13.460127 — molecular biology — Posted on 2022-02-02

3484 HOW CONCERNING IS A SARS-COV-2 VARIANT OF CONCERN? COMPUTATIONAL PREDICTIONS AND THE VARIANTS LABELING SYSTEM

Ashoor, D.; Marzouq, M.; Trabelsi, K.; Chlif, S.; Abotalib, N.; Ben Khalaf, N.; Ramadan, A.; FATHALLAH, D. M.

10.1101/2022.01.31.478425 — molecular biology — Posted on 2022-02-02

3485 The salivary microbiome shows a high prevalence of core bacterial members yet variability across human populations

Ruan, X.; Luo, J.; Zhang, P.; Howell, K.

10.1101/2021.12.13.471511 — microbiology — Posted on 2022-02-02

3486 Much more than a toxin: hydrogen cyanide is a volatile modulator of bacterial behaviour

Anand, A.; Falquet, L.; Abou-Mansour, E.; L'Haridon, F.; Keel, C.; Weisskopf, L.

10.1101/2021.09.29.462390 — microbiology — Posted on 2022-02-02

3487 Autotaxin is a Potential Link between Genetic Risk Factors and Pathogenesis of Systematic Lupus Erythematosus in Plasmacytoid Dendritic Cells

Tsuchida, Y.; Shoda, H.; Nakano, M.; Ota, M.; Okamura, T.; Yamamoto, K.; Kurano, M.; Yatomi, Y.; Fujio, K.; Sawada, T.

10.1101/2021.10.25.465592 — immunology — Posted on 2022-02-02

3488 Neural Network Poisson Models for Behavioural and Neural Spike Train Data

Khajehnejad, M.; Habibollahi Saatlou, F.; Nock, R.; Arabzadeh, E.; Dayan, P.; Dezfouli, A.

10.1101/2020.07.13.201673 — neuroscience — Posted on 2022-02-02

3489 The role of temporal coherence and temporal stability in the build-up of auditory grouping

Sollini, J. A.; Poole, K. C.; Blauth-Muszkowski, D.; Bizley, J. K.

10.1101/2021.06.27.449898 — neuroscience — Posted on 2022-02-02

3490 Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A

Elmasri, M.; Hunter, D.; Winchester, G.; Bates, E.; Aziz, W.; Moolenaar Van Der Does, D.; Karachaliou, E.; Sakimura, K.; Penn, A. C.

10.1101/2020.08.06.240010 — neuroscience — Posted on 2022-02-02

3491 Abscisic Acid Drives Stomatal Closure through Increases in Hydrogen Peroxide in Distinct Subcellular Compartments Including Mitochondria

Postliglione, A. E.; Muday, G. K.

10.1101/2022.01.11.475946 — plant biology — Posted on 2022-02-02

3492 Single-Cell Analysis Identifies Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

Viswanathan, G.; Kirshner, H. F.; Nazo, N.; Ganapathi, A.; Cumming, I.; Choi, I.; Warman, A.; Almeida-Peters, S.; Haney, J.; Corcoran, D.; Yu, Y.-R. A.; Rajagopal, S.

10.1101/2022.01.26.477878 — pathology — Posted on 2022-02-02

3493 RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

Jacquier, V.; Gitenay, D.; Fritsch, S.; Gyorffy, B.; Bonnet, S.; Jalaguier, S.; Linares, L. K.; Cavailles, V.; Teyssier, C.

10.1101/2020.07.30.228759 — cancer biology — Posted on 2022-02-02

3494 Magnesium Force Fields for OPC Water with Accurate Solvation, Ion-Binding, and Water-Exchange Properties: Successful Transfer from SPC/E

Grotz, K. K.; Schwierz, N.

10.1101/2021.12.07.471562 — biophysics — Posted on 2022-02-02

3495 AlphaFold2 and RoseTTAFold Predict Posttranslational modifications. Chromophore Formation in GFP-like Proteins.

Hartley, S. M.; Tiernan, K. A.; Ahmetaj, G.; Cretu, A.; Zhuang, Y.; Zimmer, M.

10.1101/2022.01.31.478551 — biochemistry — Posted on 2022-02-02

3496 Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients

Makinde, H.-K. M.; Dunn, J. L. M.; Gadhvi, G.; Carns, M.; Aren, K.; Chung, A. H.; Muhammad, L. N.; Song, J.; Cuda, C. M.; Dominguez, S.; Pandolfino, J. E.; Dematte D'Amico, J. E.; Budinger, G. S.; Assassi, S.; Frech, T.; Khanna, D.; Shaeffer, A.; Perlman, H.; Hinchcliff, M.; Winter, D. R.

10.1101/2022.01.29.477568 — genomics — Posted on 2022-02-02

3497 Novel genetic basis of resistance to Bt toxin Cry1Ac in Helicoverpa zea

Benowitz, K. M.; Allan, C. W.; Degain, B. A.; Li, X.; Fabrick, J. A.; Tabashnik, B. E.; Carriere, Y.; Matzkin, L. M.

10.1101/2021.11.09.467966 — genetics — Posted on 2022-02-02

3498 Foraging behavior and patch size distribution jointly determine population dynamics in fragmented landscapes

Nauta, J.; Khaluf, Y.; Simoens, P.; Martinez-Garcia, R.

10.1101/2021.11.10.468021 — ecology — Posted on 2022-02-02

3499 Kidney failure alters parathyroid Pin1 phosphorylation and parathyroid hormone mRNA binding proteins leading to secondary hyperparathyroidism

Hassan, A.; Pollak, Y. E.; Kilav-Levin, R.; Silver, J.; London, N.; Nechama, M.; Ben-Dov, I. Z.; Naveh, T.

10.1101/2021.12.06.470227 — molecular biology — Posted on 2022-02-02

3500 A pseudotyped lentivirus-based assay to titer SARS-CoV-2 neutralizing antibodies in Mexico

Cruz-Cardenas, J. A.; Gutierrez-Mayret, M.; Lopez-Arredondo, A.; Castaneda-Delgado, J. E.; Rojas-Martinez, A.; Garcia-Rivas, G.; Enciso-Moreno, J. A.; Palomares, L. A.; Brunck, M. E. G.

10.1101/2022.01.27.478128 — microbiology — Posted on 2022-02-02

3501 Extended-Spectrum Beta-Lactamase andCarbapenemase-Producing prediction inKlebsiella pneumoniaebased on MALDI-TOFmass spectra

Guerrero-Lopez, A.; Sevilla-Salcedo, C.; Candela, A.; Hernandez-Garcia, M.; Cercenado, E.; Olmos, P. M.; Canton, R.; Muñoz, P.; Gomez-Verdejo, V.; del Campo, R.; Rodriguez-Sanchez, B.

10.1101/2021.10.04.463058 — microbiology — Posted on 2022-02-02

3502 Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes

Etter, G.; van der Veldt, S.; Choi, J.; Williams, S.

10.1101/2021.12.24.474139 — neuroscience — Posted on 2022-02-02

3503 Designing and comparing cleaning pipelines for TMS-EEG data: a theoretical overview and practical example

Rogasch, N. C.; Biabani, M.; Mutanen, T. P.

10.1101/2021.11.18.469167 — neuroscience — Posted on 2022-02-02

3504 Differential microRNA expression analyses across two brain regions in Alzheimer's disease

Dobricic, V.; Schilling, M.; Schulz, J.; Zhu, L.-S.; Zhou, C.-W.; Fuss, J.; Franzenburg, S.; Zhu, L.-Q.; Parkkinen, L.; Lill, C. M.; Bertram, L.

10.1101/2021.05.31.446406 — neuroscience — Posted on 2022-02-02

3505 Stable 3D Head Direction Signals in the Primary Visual Cortex

Guitchounts, G.; Lotter, W.; Dapello, J.; Cox, D.

10.1101/2020.09.04.283762 — neuroscience — Posted on 2022-02-02

3506 A general decoding strategy explains the relationship between behavior and correlated variability

Ni, A. M.; Huang, C.; Doiron, B.; Cohen, M. R.

10.1101/2020.10.08.331850 — neuroscience — Posted on 2022-02-02

3507 Predictive uncertainty in mechanistic models of cellular processes calibrated to experimental data

Irvin, M.; Ramanathan, A.; Lopez, C. F.

10.1101/2021.05.18.444743 — systems biology — Posted on 2022-02-02

3508 Maternal age affects equine Day 8 embryo gene expression both in trophoblast and inner cell mass

Derisoud, E.; Jouneau, L.; Dubois, C.; Archilla, C.; Jaszczyszyn, Y.; Legendre, R.; Daniel, N.; Peynot, N.; Dahirel, M.; Auclair-Ronzaud, J.; Wimel, L.; Duranthon, V.; Chavatte-Palmer, P.

10.1101/2021.04.07.438786 — physiology — Posted on 2022-02-02

3509 Maternal microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice

Lopez-Tello, J.; Schofield, Z.; Kiu, R.; Dalby, M. J.; van Sinderen, D.; Le Gall, G.; Sferruzzi-Perri, A. N.; Hall, L. J.

10.1101/2021.07.23.453407 — physiology — Posted on 2022-02-02

3510 Chromosome breaks in breast cancers occur near herpes tumor virus sequences and explain why the cancer comes back

Friedenson, B. A.

10.1101/2021.11.08.467751 — cancer biology — Posted on 2022-02-02

3511 Locally-correlated kinetics of post-replication DNA methylation reveals processivity and region-specificity in DNA methylation maintenance

Ren, H.; Taylor, R. B.; Downing, T. L.; Read, E.

10.1101/2021.09.28.462223 — biophysics — Posted on 2022-02-02

3512 Reversible adhesion by type IV pili leads to formation of irreversible localized clusters

Pepe, M. V.; Dea, C.; Genskowsky, C.; Capasso, D.; Jäger, A. V.; Peruani, F.; Kierbel, A.

10.1101/2022.01.24.477649 — biophysics — Posted on 2022-02-02

3513 Multifunctional phosphate based nanoparticles as a platform for imaging, targeting and doxorubicin delivery to human breast cancer CD44+ cells.

de Totaro, P. I. S.

10.1101/2021.11.08.467718 — bioengineering — Posted on 2022-02-02

3514 An automated workflow for multiplexed single-cell proteomics sample preparation at unprecedented sensitivity.

Ctortecka, C.; Hartlmayr, D.; Seth, A.; Mendjan, S.; Tourniaire, G.; Mechtler, K.

10.1101/2021.04.14.439828 — biochemistry — Posted on 2022-02-02

3515 Selective Ablation of 3' RNA ends and Processive RTs Facilitate Direct cDNA Sequencing of Full-length Host cell and Viral Transcripts

Gallardo, C. M.; Nguyen, A.-V. T.; Routh, A. L.; Torbett, B. E.

10.1101/2022.01.27.478099 — genomics — Posted on 2022-02-02

3516 Native American Ancestry and Pigmentation Allele Contributions to Skin Color in a Caribbean Population

Ang, K. C.; Canfield, V. A.; Foster, T. C.; Reid, K. P.; Leong, S. L.; Kawasawa, Y. I.; Liu, D.; Hawley, J.; Cheng, K. C.

10.1101/2021.11.24.469305 — genetics — Posted on 2022-02-02

3517 Regulatory architecture of the RCA gene cluster captures an intragenic TAD boundary, CTCF-mediated chromatin looping and a long-range intergenic enhancer

Cheng, J.; Clayton, J. S.; Acemel, R. D.; Zheng, Y.; Taylor, R. L.; Keles, S.; Franke, M.; Boackle, S. A.; Harley, J. B.; Quail, E.; Gomez-Skarmeta, J. L.; Ulgiati, D.

10.1101/2020.02.16.941070 — genetics — Posted on 2022-02-02

3518 Euchromatin factors HULC and Set1C affect heterochromatin organization for mating-type switching in fission yeast Schizosaccharomyces pombe

Chavez, A. E.; Maki, T.; Tsubouchi, H.; Handa, T.; Kimura, H.; Haber, J. E.; Thon, G.; Iwasaki, H.

10.1101/2021.03.23.436714 — genetics — Posted on 2022-02-02

3519 Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary Dysplasia

Gao, F.; Li, C.; Smith, S.; Peinado, N.; Kohbodi, G.; Tran, E.; Loh, E.; Li, W.; Borok, Z.; Peter, I.; Minoo, P.

10.1101/2022.01.24.477613 — developmental biology — Posted on 2022-02-02

3520 Canonical babbling during vocal turn taking and independent vocal play

Long, H. L.; Ramsay, G.; Bowman, D. D.; Burkhardt-Reed, M.; Oller, D. K.

10.1101/2020.10.09.333872 — developmental biology — Posted on 2022-02-02

3521 CONTEXT-DEPENDENT ENHANCER FUNCTION REVEALED BYTARGETED INTER-TAD RELOCATION

Bolt, C. C.; Lopez-Delisle, L.; Hintermann, A.; Mascrez, B.; Rauseo, A.; Andrey, G.; Duboule, D.

10.1101/2022.01.19.476888 — developmental biology — Posted on 2022-02-02

3522 The Growth Hormone Releasing Hormone Signaling Pathway Governs Cardiomyocyte differentiation in human iPS cells.

Wanschel, A.; Salerno, A. G.; Kuznetsov, J.; Kurtenbach, S.; Rodriguez, D. A.; Valasaki, K.; Balkan, W.; Dykxhoorn, D.; Schally, A.; Hare, J.; Chatzistergos, K.

10.1101/2022.01.31.478572 — cell biology — Posted on 2022-02-02

3523 Merkel cell polyomavirus regulates miR183 cluster and piR62011 in Merkel cell carcinoma

Arora, R.; Dohadwala, L.; Nanavati, B. N.; Lakshmanan, V.; Mukherjee, S.

10.1101/2022.01.18.476776 — molecular biology — Posted on 2022-02-02

3524 Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and enhance protection of anti-CSP monoclonal antibodies

Wilder, B. K.; Vigdorovich, V.; Carbonetti, S.; Minkah, N.; Hertoghs, N.; Raappana, A.; Cardamone, H.; Oliver, B. G.; Trakhimets, O.; Kumar, S.; Dambrauskas, N.; Arredondo, S. A.; Camargo, N.; Kappe, S. H. I.; Sather, D. N.

10.1101/2021.10.15.464611 — microbiology — Posted on 2022-02-02

3525 Nanoscale colocalization of NK cell activating and inhibitory receptors controls signal integration

Tomaz, D.; Pereira, P. M.; Guerra, N.; Dyson, J.; Gould, K.; Henriques, R.

10.1101/266429 — immunology — Posted on 2022-02-02

3526 Transmembrane Batten disease proteins interact with a shared network of vesicle sorting proteins to regulate synaptic composition and function.

Rechtzigel, M. J.; Meyerink, B. L.; Leppert, H.; Johnson, T. B.; Cain, J. T.; Ferrandino, G.; May, D. G.; Roux, K. J.; Brudvig, J. J.; Weimer, J. M.

10.1101/2021.09.16.460691 — neuroscience — Posted on 2022-02-02

3527 Neural activity during story listening is synchronized across individuals despite acoustic masking

Irsik, V. C.; Johnsrude, I.; Herrmann, B.

10.1101/2021.03.25.437022 — neuroscience — Posted on 2022-02-02

3528 Dive performance and aquatic thermoregulation of the world's smallest mammalian diver, the American water shrew (Sorex palustris)

Gusztak, R. W.; MacArthur, R. A.; Campbell, K. L.

10.1101/2021.06.02.446801 — zoology — Posted on 2022-02-02

3529 Adapting to extremes: reconstructing evolution in response to changing climate over time and space in the diverse Australian plant genus Acacia

Hua, X.; Cardillo, M.; Bromham, L.

10.1101/2021.05.08.443013 — plant biology — Posted on 2022-02-02

3530 Ion Permeation, Selectivity, and Electronic Polarization in Fluoride Channels

Yue, Z.; Wang, Z.; Voth, G. A.

10.1101/2021.12.08.471811 — biophysics — Posted on 2022-02-02

3531 Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1

Lindon, C.; Abdelbaki, A. A.; Ascanelli, C.; Okoye, C.; Akman, H. B.; Janson, G.; Min, M.-w.; Marcozzi, C.; Hagting, A.; Grant, R.; De Luca, M.; Asteriti, I. A.; Guarguaglini, G.; Paiardini, A.

10.1101/2022.01.31.478464 — cell biology — Posted on 2022-02-02

3532 Molecular mechanisms involved in Atlantic halibut (Hippoglossus hippoglossus) egg quality: impairments at transcription and protein folding levels induce inefficient protein and energy homeostasis during early development

Yilmaz, O.; Mangor Jensen, A.; Harboe, T.; Mogster, M.; Mangor Jensen, R.; Mjaavatten, O.; Birkeland, E.; Spriet, E.; Sandven, L.; Furmanek, T.; Berven, F.; Norberg, B.; Wargelius, A.

10.1101/2022.02.01.478612 — molecular biology — Posted on 2022-02-02

3533 Large-scale exploration of whole-brain structural connectivity in anorexia nervosa: alterations in the connectivity of frontal and subcortical networks

Lloyd, E. C.; Foerde, K. E.; Muratore, A. F.; Aw, N.; Semanek, D.; Steinglass, J. E.; Posner, J.

10.1101/2021.10.05.463197 — neuroscience — Posted on 2022-02-02

3534 Subclonal evolution and expansion of THY1-positive cells is associated with recurrence in glioblastoma

Al-Holou, W. N.; Wang, H.; Ravikumar, V.; Oneka, M.; Verhaak, R.; Kim, H.; Pratt, D.; Camelo-Piragua, S.; Speers, C.; Wahl, D.; Shankar, S.; Hollon, T.; Sagher, O.; Heth, J.; Muraszko, K.; Lawrence, T. S.; de Carvalho, A.; Mikkelsen, T.; Rao, A.; Rehemtulla, A.

10.1101/2021.09.10.459454 — cancer biology — Posted on 2022-02-02

3535 Diversity and dynamics of the CRISPR-Cas systems associated with Bacteroides fragilis in human population

Lam, T. L.; Mortensen, K.; Ye, Y.

10.1101/2021.09.09.459629 — bioinformatics — Posted on 2022-02-02

3536 Cellular genome wide association study identifies common genetic variation influencing lithium induced neural progenitor proliferation

Wolter, J. M.; Le, B. D.; Matoba, N.; Michael, L. J.; Aygun, N.; Liang, D.; Courtney, K.; Piven, J.; Zylka, M.; Stein, J. L.

10.1101/2022.01.31.478307 — genetics — Posted on 2022-02-02

3537 The transformability of genotype-phenotype landscapes

Srivastava, M.; Payne, J. L.

10.1101/2022.02.01.478629 — evolutionary biology — Posted on 2022-02-02

3538 Involvement of non-LTR retrotransposons in the cancer incidence and lifespan of mammals

Ricci, M.; Peona, V.; Taccioli, C.

10.1101/2021.09.27.461867 — evolutionary biology — Posted on 2022-02-02

3539 A cell fate decision map reveals abundant direct neurogenesis in the human developing neocortex

Coquand, L.; Mace, A.-S.; Farcy, S.; Avalos, C. B.; Di Cicco, A.; Lampic, M.; Bessieres, B.; Attie-Bitach, T.; Fraisier, V.; Guimiot, F.; Baffet, A.

10.1101/2022.02.01.478661 — developmental biology — Posted on 2022-02-02

3540 A multi-omics approach to visualize early neuronal differentiation in 4D

Samara, A.; Spildrejorde, M.; Sharma, A.; Falck, M.; Leithaug, M.; Modafferi, S.; Bjornstad, P. M.; Acharya, G.; Gervin, K.; Lyle, R.; Eskeland, R.

10.1101/2022.02.01.478732 — cell biology — Posted on 2022-02-02

3541 Dissociable neural correlates of multisensory coherence and selective attention

Peng, F.; Bizley, J. K.; SCHNUPP, J.; auksztulewicz, r.

10.1101/2022.02.01.478616 — neuroscience — Posted on 2022-02-02

3542 Oscillations without cortex: Working memory modulates brainwaves in the endbrain of crows

Hahn, L. A.; Balakhonov, D.; Lundqvist, M.; Nieder, A.; Rose, J.

10.1101/2022.02.01.478165 — neuroscience — Posted on 2022-02-02

3543 Impact of α-synuclein fibrillar strains and β-amyloid assemblies on mouse cortical neurons endo-lysosomal logistics

Chou, Q.-L.; Alik, A.; Marquier, F.; Melki, R.; Treussart, F.; Simonneau, M.

10.1101/2021.05.15.444288 — neuroscience — Posted on 2022-02-02

3544 Genetic diversity analysis and characterization of Ugandan sorghum

Chakrabarty, S.; Mufumbo, R.; Jordan, D.; Windpassinger, S.; Mace, E.; Snowdon, R.; Hathorn, A.

10.1101/2022.01.31.478463 — plant biology — Posted on 2022-02-01

3545 Inside-out tracking and projection mapping for robot-assisted transcranial magnetic stimulation

Liu, Y.; Liu, S.; Sefati, S.; Tian, J.; Kheradmand, A.; Armand, M.

10.1101/2022.01.30.478399 — bioengineering — Posted on 2022-02-01

3546 Non-self RNA rewires IFNβ signaling: A mathematical model of the innate immune response

Korwek, Z.; Czerkies, M.; Jaruszewicz-Blonska, J.; Prus, W.; Kosiuk, I.; Kochanczyk, M.; Lipniacki, T.

10.1101/2022.01.30.478391 — immunology — Posted on 2022-02-01

3547 Psychedelics and schizophrenia: Distinct alterations to Bayesian inference

Rajpal, H.; Mediano, P.; Rosas, F.; Timmermann, C.; Brugger, S.; Muthukumaraswamy, S. D.; Seth, A.; Bor, D.; Carhart-Harris, R.; Jensen, H. J.

10.1101/2022.01.31.478484 — neuroscience — Posted on 2022-02-01

3548 Stable Potassium Isotopes (41K/39K) Track Transcellular and Paracellular Potassium Transport in Biological Systems

Higgins, J. A.; Santiago-Ramos, D.; Gili, S.; Spetea, C.; Kanoski, S.; Ha, D.; McDonough, A. A.; Youn, J. H.

10.1101/2022.01.31.478485 — physiology — Posted on 2022-02-01

3549 Cilia stimulatory and antibacterial activities of bitter receptor agonist diphenhydramine: insights into potential complimentary strategies for CF nasal infections

Kuek, L. E.; McMahon, D. B.; Ma, R. Z.; Miller, Z. A.; Jolivert, J. F.; Adappa, N. D.; Palmer, J. N.; Lee, R. J.

10.1101/2022.01.31.478409 — physiology — Posted on 2022-02-01

3550 A Deep Learning solution for triaging patient with cancer from their predicted mutational status using histopathological images

Morel, L.-O.; Derangere, V.; Arnould, L.; Ladoire, S.; Vincon, N.

10.1101/2022.01.30.475484 — bioinformatics — Posted on 2022-02-01

3551 The mitoXplorer 2.0 update: integrating and interpreting mitochondrial expression dynamics within a cellular context

Marchiano, F.; Haering, M.; Habermann, B. H.

10.1101/2022.01.31.478461 — bioinformatics — Posted on 2022-02-01

3552 VeChat: Correcting errors in long reads using variation graphs

Luo, X.; Kang, X.; Schonhuth, A.

10.1101/2022.01.30.478352 — bioinformatics — Posted on 2022-02-01

3553 Gene Expression Meta-Analysis of Colon Rectal Cancer Tumour Cells Reveals Genes in Association With Tumorogenesis.

Vaja, R. D.

10.1101/2022.01.30.478381 — bioinformatics — Posted on 2022-02-01

3554 Mesenchymal stem cells support human vascular endothelial cells to form vascular sprouts in human platelet lysate-based matrices.

Rossmanith, E.; Summer, S.; Pasztorek, M.; Fiedler, C.; Groeger, M.; Rauscher, S.; Weber, V.; Fischer, M. B.

10.1101/2022.01.31.478452 — bioengineering — Posted on 2022-02-01

3555 Understanding Chicks' Emotions: Are Eye Blinks & Facial Temperatures Reliable Indicators?

Pijpers, N.; Heuvel, H. v. d.; Duncan, I. J.; Yorzinski, J.; Neethirajan, S.

10.1101/2022.01.31.478468 — animal behavior and cognition — Posted on 2022-02-01

3556 Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Ku, Z.; Xie, X.; Lin, J.; Gao, P.; Sahili, A. E.; Su, H.; Liu, Y.; Ye, X.; Li, X.; Fan, X.; Goh, B. C.; Xiong, W.; Boyd, H.; Muruato, A. E.; Deng, H.; Xia, H.; Jing, Z.; Kalveram, B. K.; Menachery, V. D.; Zhang, N.; Lescar, J.; Shi, P.-Y.; An, Z.

10.1101/2022.02.01.478504 — microbiology — Posted on 2022-02-01

3557 New efficient intercellular spread mode of respiratory syncytial virus contributes to neutralization escape and persistence

Zhang, W.; Lin, X.; Zhang, L.-J.; Chen, L.; Sun, Y.-P.; Si, J.-Y.; Zhao, M.; Wu, G.-H.; Zhan, L.-T.; Wang, Y.-B.; Xia, N.; Zheng, Z.-Z.

10.1101/2022.02.01.478688 — microbiology — Posted on 2022-02-01

3558 Deep proteome analysis of plasma reveals novel biomarkers of mild cognitive impairment and Alzheimer's disease: A longitudinal study

Kaur, G.; Poljak, A.; Sachdev, P.

10.1101/2022.01.30.478370 — neuroscience — Posted on 2022-02-01

3559 The effect of treatment of auxin producing bacterial culture supernatant in combination with organic and inorganic fertilizers

Park, S.; Shin, J.-H.

10.1101/2022.01.31.478466 — plant biology — Posted on 2022-02-01

3560 Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

Kavanagh, M. E.; Horning, B. D.; Khattri, R.; Roy, N.; Lu, J. P.; Whitby, L. R.; Brannon, J. C.; Parker, A.; Chick, J. M.; Eissler, C. L.; Wong, A.; Rodriguez, J. L.; Rodiles, S.; Masuda, K.; Teijaro, J. R.; Simon, G. M.; Patricelli, M. P.; Cravatt, B. F.

10.1101/2022.01.31.478302 — pharmacology and toxicology — Posted on 2022-02-01

3561 CRISPR-based multi-locus real-time tracking reveals single chromosome dynamics and compaction

Chung, Y.-C.; Bisht, M.; Tu, L.-C.

10.1101/2022.02.01.478681 — biophysics — Posted on 2022-02-01

3562 QSMRim-Net: Imbalance-Aware Learning for Identification of Chronic Active Multiple Sclerosis Lesions on Quantitative Susceptibility Maps

Zhang, H.; Nguyen, T. D.; Zhang, J.; Marcille, M.; Spincemaille, P.; Wang, Y.; Gauthier, S. A.; Sweeney, E. M.

10.1101/2022.01.31.478482 — bioinformatics — Posted on 2022-02-01

3563 Injectable hydrogels with phase-separated structures that can encapsulate live cells

Ishikawa, S.; Yoshikawa, Y.; Kamata, H.; Chung, U.-i.; Sakai, T.

10.1101/2022.01.31.478579 — bioengineering — Posted on 2022-02-01

3564 Fundamental limits of amplification-free CRISPR-Cas12 and Cas13 diagnostics

Huyke, D. A.; Ramachandran, A.; Bashkirov, V. I.; Kotseroglou, E. K.; Kotseroglou, T.; Santiago, J. G.

10.1101/2022.01.31.478567 — bioengineering — Posted on 2022-02-01

3565 Plankton energy flows using a global size-structured and trait-based model

Negrete-Garcia, G.; Luo, J. Y.; Long, M. C.; Lindsay, K.; Levy, M.; Barton, A. D.

10.1101/2022.02.01.478546 — biochemistry — Posted on 2022-02-01

3566 The Collaborative Cross strains and their founders vary widely in cocaine-induced behavioral sensitization

Schoenrock, S.; Gagnon, L.; Olson, A.; Leonardo, M.; Philip, V. M.; He, H.; Jentsch, J. D.; Chesler, E.; Tarantino, L.

10.1101/2022.02.01.478694 — genetics — Posted on 2022-02-01

3567 Human immunodeficiency virus type 2 capsid protein mutagenesis defines the determinants for Gag-Gag interactions

Yang, H.; Talledge, N.; Arndt, W. E.; Zhang, W.; Mansky, L.

10.1101/2022.01.31.478542 — microbiology — Posted on 2022-02-01

3568 Activation of a bacterial flow sensor by hypochlorous acid from stimulated neutrophils

Foik, I. P.; Urban, L. A.; Huang, A. P.; Downing, T. L.; Siryaporn, A.

10.1101/2022.02.01.478687 — microbiology — Posted on 2022-02-01

3569 HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus Maturation

Talledge, N.; Yang, H.; Shi, K.; Yu, G.; Arndt, W. G.; Mendonca, L.; Aihara, H.; Mansky, L. M.; Zhang, W.

10.1101/2022.02.01.478508 — microbiology — Posted on 2022-02-01

3570 Identification of interacting proteins of maize mosaic virus glycoprotein in its vector, Peregrinus maidis.

Alviar, K. B.; Rotenberg, D.; Martin, K. M.; Whitfield, A. E.

10.1101/2022.02.01.478665 — microbiology — Posted on 2022-02-01

3571 Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells.

Lee, S. h.; Hao, Y.; Gui, T.; Dotti, G.; Savoldo, B.; Zou, F.; Kafri, T.

10.1101/2022.02.01.478686 — microbiology — Posted on 2022-02-01

3572 Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand

Herod, M. R.; Ward, J.; Tuplin, A.; Harris, M.; Stonehouse, N. J.; McCormick, C. J.

10.1101/2022.02.01.478670 — microbiology — Posted on 2022-02-01

3573 Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolution

Liang, W.; Tan, T. J. C.; Wang, Y.; Lv, H.; Sun, Y.; Bruzzone, R.; Mok, C. K. P.; Wu, N. C.

10.1101/2022.01.31.478576 — microbiology — Posted on 2022-02-01

3574 Three models of vaccination strategies against cryptococcosis in immunocompromised hosts using heat-killed Cryptococcus neoformans Δsgl1

Normile, T.; Del Poeta, M.

10.1101/2022.01.31.478598 — microbiology — Posted on 2022-02-01

3575 The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

Hsu, C. G.; Chavez, C. L.; Zhang, C.; Sowden, M.; Yan, C.; Berk, B. C.

10.1101/2022.02.01.478693 — immunology — Posted on 2022-02-01

3576 TYPE I INTERFERON-DEPENDENT CELLULAR REMODELING DURING ACUTE PULMONARY MHV INFECTION

Grabherr, S.; Waltenspuehl, A.; Luetge, M.; Buechler, L.; Cheng, H.-W.; Zielinska, K.; Caviezel-Firner, S.; Krebs, P.; Ludewig, B.; Pikor, N. B.

10.1101/2022.02.01.478627 — immunology — Posted on 2022-02-01

3577 Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription

dos Santos, A.; Rollins, D. E.; Hari-Gupta, Y.; Reed, H. C.; Du, M.; Ru, S. Y. Z.; Pidlisna, K.; Stranger, A.; Lorgat, F.; Brown, I.; Howland, K.; Arron, J.; Wang, L.; Ellis, P. J.; Chew, T. L.; Martin-Fernandez, M. L.; Pyne, A. L. B.; Toseland, C. P.

10.1101/2022.02.01.478690 — biophysics — Posted on 2022-02-01

3578 Pancreatic Tumor Eradication via Selective PIN1 Inhibition in Cancer Associated Fibroblasts and T Lymphocytes Engagement

Liu, J.; Wen, T.; Li, Z.; Liu, Y.

10.1101/2022.01.31.478589 — bioengineering — Posted on 2022-02-01

3579 Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

Bitto, A.; Grillo, A. S.; Stanaway, I. B.; Nguyen, B. M. G.; Ying, K.; Tung, H.; Smith, K.; Tran, N.; Velikanje, G.; Urfer, S.; Snyder, J. M.; Kayser, E.-B.; Wang, L.; Smith, D. L.; Thompson, J. W.; Dubois, L.; DePaolo, W.; Kaeberlein, M.

10.1101/2022.01.31.478591 — biochemistry — Posted on 2022-02-01

3580 AlphaFold2 and RoseTTAFold Predict Posttranslational modifications. Chromophore Formation in GFP-like Proteins.

Hartley, S.; Tiernan, K.; Ahmetaj, G.; Cretu, A.; Zhuang, Y.; Zimmer, M.

10.1101/2022.01.31.478551 — biochemistry — Posted on 2022-02-01

3581 Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis

Djeghloul, D.; Dimond, A.; Kramer, H.; Brown, K.; Patel, B.; Wang, Y.-F.; Futschik, M.; whilding, C.; Montoya, A.; Veland, N.; cheriyamkunnel, S.; Montavon, T.; Jenuwein, T.; Merkenschlager, M.; Fisher, A. G.

10.1101/2022.02.01.478684 — molecular biology — Posted on 2022-02-01

3582 Optimization of NLS Composition Improves CRISPR-Cas12a Editing Rates in Human Primary Cells

Luk, K.; Liu, P.; Zeng, J.; Wang, Y.; Maitland, S. A.; Idrizi, F.; Ponnienselvan, K.; Zhu, L. J.; Luban, J.; Bauer, D. E.; Wolfe, S.

10.1101/2022.02.01.478672 — molecular biology — Posted on 2022-02-01

3583 An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii

May, R. C.; Saidykhan, L.; Correia, J.; Romanyuk, A.; Desanti, G. E.; Taylor-Smith, L.; Makarova, M.; Ballou, E. R.

10.1101/2022.02.01.478613 — microbiology — Posted on 2022-02-01

3584 Single-cell RNA profiling of Plasmodium vivax liver stages reveals parasite- and host- specific transcriptomic signatures and drug targets

Ruberto, A. A.; Maher, S. P.; Vantaux, A.; Joyner, C. J.; Bourke, C.; Balan, B.; Jex, A.; Mueller, I.; Witkowski, B.; Kyle, D. E.

10.1101/2022.02.01.478648 — microbiology — Posted on 2022-02-01

3585 Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

Bertuzzi, M.; Howell, G. J.; Thomson, D. D.; Fortune-Grant, R.; Moeslinger, A.; Dancer, P.; Van Rhijn, N.; Motsi, N.; Du, X.; Codling, A.; Shah, R.; Demirbag, M.; Bignell, E.

10.1101/2022.02.01.478664 — microbiology — Posted on 2022-02-01

3586 The gut bacterial community potentiates Clostridioides difficile infection severity

Lesniak, N. A.; Schubert, A. M.; Flynn, K. J.; Leslie, J. L.; Sinani, H.; Bergin, I. L.; Young, V. B.; Schloss, P. D.

10.1101/2022.01.31.478599 — microbiology — Posted on 2022-02-01

3587 A widespread group of large plasmids in methanotrophic Methanoperedens archaea

Schoelmerich, M. C.; Ouboter, H. T.; Sachdeva, R.; Penev, P.; Amano, Y.; West-Roberts, J. A.; Welte, C. U.; Banfield, J. F.

10.1101/2022.02.01.478723 — microbiology — Posted on 2022-02-01

3588 Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

Bommireddy, R.; Stone, S.; Bhatnagar, N.; Kumari, P.; Munoz, L. E.; Oh, J.; Kim, K.-H.; Berry, J. T.; Jacobsen, K.; Lahcen, J.; Naing, S.-H.; Blackerby, A. N.; Gaag, T. V. d.; Wright, C. N.; Lai, L.; Pack, C. D.; Ramachandiran, S.; Suthar, M. S.; Kang, S.-M.; Kumar, M.; Reddy, S. J.; Selvaraj, P.

10.1101/2022.02.01.478657 — immunology — Posted on 2022-02-01

3589 Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

Wang, Z.; Muecksch, F.; Cho, A.; Gaebler, C.; Hoffmann, H.-H.; Ramos, V.; Zong, S.; Cipolla, M.; Johnson, B.; Schmidt, F.; DaSilva, J.; Bednarski, E.; Tanfous, T. B.; Raspe, R.; Yao, K.; Lee, Y. E.; Chen, T.; Turroja, M.; Millard, K. G.; Dizon, J.; Kaczynska, A.; Gazumyan, A.; Oliveira, T. Y.; Rice, C. M.; Caskey, M.; Bieniasz, P. D.; Hatziioannou, T.; Barnes, C. O.; Nussenzweig, M. C.

10.1101/2022.02.01.478695 — immunology — Posted on 2022-02-01

3590 A model of autonomous interactions between hippocampus and neocortex driving sleep-dependent memory consolidation

Singh, D.; Norman, K. A.; Schapiro, A. C.

10.1101/2022.01.31.478475 — neuroscience — Posted on 2022-02-01

3591 Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients.

Hafiz, R.; Gandhi, T. K.; Misrhra, S.; Prasad, A.; Mahajan, V.; Natelson, B.; Di, X.; Biswal, B.

10.1101/2022.02.01.478677 — neuroscience — Posted on 2022-02-01

3592 Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

Qazi, M. A.; Salim, S. K.; Brown, K. R.; Mikolajewicz, N.; Savage, N.; Han, H.; Subapanditha, M. K.; Bakhshinyan, D.; Nixon, A.; Vora, P.; Desmond, K.; Chokshi, C.; Singh, M.; Khoo, A.; Macklin, A.; Khan, S.; Tatari, N.; Winegarden, N.; Richards, L. M.; Pugh, T.; Bock, N.; Mansouri, A.; Venugopal, C.; Kislinger, T. R.; Goyal, S.; Moffat, J.; Singh, S. K.

10.1101/2022.01.28.478232 — cancer biology — Posted on 2022-02-01

3593 CopyMix: Mixture Model Based Single-Cell Clustering and Copy Number Profiling using Variational Inference

Safinianaini, N.; P. E. de Souza, C.; Lagergren, J.

10.1101/2020.01.29.926022 — bioinformatics — Posted on 2022-02-01

3594 HOW CONCERNING IS A SARS-COV-2 VARIANT OF CONCERN? COMPUTATIONAL PREDICTIONS AND THE VARIANTS LABELING SYSTEM

Ashoor, D.; Marzouq, M.; Trabelsi, K.; Chlif, S.; Abotalib, N.; Ben Khalaf, N.; Ramadan, A.; FATHALLAH, D. M.

10.1101/2022.01.31.478425 — molecular biology — Posted on 2022-02-01

3595 Semi-automated analysis of an optical ATP indicator in neurons

Dehkharghanian, T.; Hashemiaghdam, A.; Ashrafi, G.

10.1101/2021.09.20.461141 — neuroscience — Posted on 2022-02-01

3596 An interactome landscape of SARS-CoV-2 virus-human protein-protein interactions by protein sequence-based multi-label classifiers

Lee, H.-J.

10.1101/2021.11.07.467640 — systems biology — Posted on 2022-02-01

3597 A Time-calibrated Firefly (Coleoptera: Lampyridae) Phylogeny: Using Genomic Data for Divergence Time Estimation

Hoehna, S.; Lower, S. E.; Duchen, P.; Catalan, A.

10.1101/2021.11.19.469195 — evolutionary biology — Posted on 2022-02-01

3598 Significant Broad Spectrum Antiviral activity of Bi121 Against Different Variants of SARS-CoV-2

Subhadra, B.; Agrawal, R.; Pal, V. K.; Chenine, A.; Mattathil, J. G.; Singh, A.

10.1101/2022.01.29.477140 — microbiology — Posted on 2022-02-01

3599 A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

Jiang, L.; Driedonks, T.; Lowman, M.; Jong, W. S.; van den Berg van Saparoea, H. B.; Dhakal, S.; Zhou, R.; Caputo, C.; Littlefield, K.; Sitaras, I.; Chen, M. W.; Lima, G.; Gololobova, O.; Smith, B.; Mahairaki, V.; Richardson, M. R.; Mulka, K. R.; Lane, A. P.; Klein, S. L.; Pekosz, A.; Brayton, C. F.; Mankowski, J. L.; Luirink, J.; Villano, J. S.; Witwer, K. W.

10.1101/2021.06.28.450181 — immunology — Posted on 2022-02-01

3600 Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice

Brooks, S. D.; Smith, R. L.; Moreira, A. d. S.; Ackerman, H.

10.1101/2021.10.19.465025 — pharmacology and toxicology — Posted on 2022-02-01

3601 D155Y Substitution of SARS-CoV-2 ORF3a Weakens Binding with Caveolin-1

Gupta, S.; Mallick, D.; Banerjee, K.; Mukherjee, S.; Sarkar, S.; Lee, S. T. M.; Basuchowdhuri, P.; Jana, S. S.

10.1101/2021.03.26.437194 — bioinformatics — Posted on 2022-02-01

3602 Outbreak.info Research Library: A standardized, searchable platform to discover and explore COVID-19 resources and data

Tsueng, G.; Mullen, J.; Alkuzweny, M.; Cano, M. A.; Rush, B.; Haag, E.; Outbreak Curators, ; Latif, A. A.; Zhou, X.; Qian, Z.; Andersen, K. G.; Wu, C.; Su, A. I.; Gangavarapu, K.; Hughes, L. D.

10.1101/2022.01.20.477133 — bioinformatics — Posted on 2022-02-01

3603 Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.

Patten, J.; Keiser, P. T.; Gysi, D. M.; Menichetti, G.; Mori, H.; Donahue, C. J.; Gan, X.; do Valle, I. F.; Geoghegan-Barek, K.; Anantpadma, M.; Boytz, R.; Berrigan, J. L.; Hulsey-Stubbs, S.; Ayazika, K. T.; O'Leary, C.; Jalloh, S. C.; Wagner, F.; Ayehunie, S.; Elledge, S.; Anderson, D.; Loscalzo, J.; Zitnik, M.; Gummuluru, S.; Namchuk, M. N.; Barabasi, A.-L.; Davey, R. A.

10.1101/2021.04.20.440626 — microbiology — Posted on 2022-02-01

3604 The ABA INSENSITIVE (ABI) 4 transcription factor is stabilized by stress, ABA and phosphorylation

Maymon, T.; Eisner, N.; Bar-Zvi, D.

10.1101/2022.02.01.478625 — plant biology — Posted on 2022-02-01

3605 Bimodally oriented cellulose fibers and reticulated homogalacturonan networks - A direct visualization of Allium cepa primary cell walls

NICOLAS, W. J.; Faessler, F.; Schur, F. K.; Dutka, P.; Meyerowitz, E. M.; Jensen, G. J.

10.1101/2022.01.31.478342 — plant biology — Posted on 2022-02-01

3606 Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19

Khoo, W. H.; Jackson, K.; Phetsouphanh, C.; Zaunders, J.; Alquicira-Hernandez, J.; Yazar, S.; Ruiz-Diaz, S.; Singh, M.; Dhenni, R.; Kyaw, W.; Tea, F.; Merheb, V.; Lee, F.; Burrell, R.; Howard-Jones, A.; Koirala, A.; Zhou, L.; Yuksel, A.; Catchpoole, D.; Lai, C. L.; Vitagliano, T. L.; Rouet, R.; Christ, D.; Tang, B.; West, N.; George, S.; Gerrard, J.; Croucher, P. I.; Kelleher, A. D.; Goodnow, C. G.; Sprent, J. D.; Powell, J. D.; Brilot, F.; Nanan, R.; Hsu, P. S.; Deenick, E. K.; Britton, P. N.; Phan, T. G.

10.1101/2022.01.30.478400 — immunology — Posted on 2022-02-01

3607 SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology

Shen, W.-B.; Logue, J.; Yang, P.; Baracco, L.; Elahi, M.; Reece, E. A.; Wang, B.; Li, L.; Blanchard, T.; Han, Z.; Frieman, M.; Rissman, R. A.; Yang, P.

10.1101/2022.01.31.478476 — neuroscience — Posted on 2022-02-01

3608 Lipid-mediated nuclear moonlighting of cytosolic glyceraldehyde-3-phosphate dehydrogenase in plant heat response

Wang, X.; Kim, S.-C.; Yao, S.; Zhang, Q.

10.1101/2022.01.31.478510 — plant biology — Posted on 2022-02-01

3609 Using Unassigned NMR Chemical Shifts to Model RNA Secondary Structure

Moudgal, N.; Arhin, G.; Frank, A. T.

10.1101/2022.01.30.478380 — biophysics — Posted on 2022-02-01

3610 A Genetically Encoded BRET-based SARS-CoV-2 Mpro Protease Activity Sensor

Geethakumari, A. M.; Ahmed, W. S.; Rasool, S. H.; Fatima, A. H.; Uddin, S. M. N.; Aouida, M. H.; Biswas, K. H.

10.1101/2022.01.31.478460 — biophysics — Posted on 2022-02-01

3611 Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries

Arhontoulis, D. C.; Kerr, C.; Richards, D.; Tjen, K.; Hyams, N.; Jones, J. A.; Deleon-Pennell, K.; Menick, D. R.; Lindner, D.; Westermann, D.; Mei, Y.

10.1101/2022.01.31.478497 — bioengineering — Posted on 2022-02-01

3612 Genome-wide CRISPR Screens Identify Ferroptosis as a Novel Therapeutic Vulnerability in Acute Lymphoblastic Leukemia

Lalonde, M.-E.; Sasseville, M.; Gelinas, A.-M.; Milanese, J.-S.; Beland, K.; Drouin, S.; Haddad, E.; Marcotte, R.

10.1101/2022.02.01.478478 — cancer biology — Posted on 2022-02-01

3613 CMTR1 is recruited to transcription start sites and promotes ribosomal protein and histone gene expression in embryonic stem cells

Liang, S.; Silva, J. C.; Suska, O.; Lukoszek, R.; Almohammed, R.; Cowling, V. H.

10.1101/2022.02.01.478435 — cell biology — Posted on 2022-02-01

3614 Profilin 1 deficiency drives mitotic defects and impairs genome stability

Scotto di Carlo, F.; Russo, S.; Muyas, F.; Mangini, M.; Pazzaglia, L.; Biamonte, F.; De Luca, A. C.; Scotlandi, K.; Cortes-Ciriano, I.; Gianfrancesco, F.

10.1101/2022.02.01.478160 — cell biology — Posted on 2022-02-01

3615 Mitophagy mediates beige to white transition of human primary subcutaneous adipocytes ex vivo

Vamos, A.; Shaw, A.; Varga, K.; Csomos, I.; Mocsar, G.; Balajthy, Z.; Lanyi, C.; Bacso, Z.; Szatmari-Toth, M.; Kristof, E.

10.1101/2022.02.01.478645 — cell biology — Posted on 2022-02-01

3616 Rapid stem cell spreading induced by high affinity α5β1 integrin-selective bicyclic RGD peptide in biomimetic hydrogels

Liu, K.; Vandaele, J.; Bernhagen, D.; van Erp, M.; Oosterwijk, E.; Timmerman, P.; Rocha, S.; Kouwer, P. H. J.

10.1101/2022.02.01.478177 — biophysics — Posted on 2022-02-01

3617 Mathematical model of chromosomal dynamics during DNA double strand break repair in budding yeast

Nakahata, S.; Fujii, M.; Awazu, A.

10.1101/2022.02.01.478611 — biophysics — Posted on 2022-02-01

3618 Skin epithelial cells change their mechanics and proliferation upon Snail-mediated EMT signalling

Hosseini, K.; Trus, P.; Frenzel, A.; Werner, C.; Fischer-Friedrich, E.

10.1101/2022.02.01.478626 — biophysics — Posted on 2022-02-01

3619 Quantifying template signatures of center-of-mass motion during walking with ankle exoskeletons

Rosenberg, M. C.; Proctor, J. L.; Steele, K. M.

10.1101/2022.01.31.478514 — systems biology — Posted on 2022-02-01

3620 Universal structural requirements for maximal robust perfect adaptation in biomolecular networks

Gupta, A.; Khammash, M.

10.1101/2022.02.01.478605 — systems biology — Posted on 2022-02-01

3621 Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

Wang, Y.; Malik, S.; Suh, H.-W.; Xiao, Y.; Deng, Y.; Fan, R.; Huttner, A.; Bindra, R. S.; Saltzman, W. M.; Bahal, R.

10.1101/2022.01.31.478549 — cancer biology — Posted on 2022-02-01

3622 Vitamin D receptor cistrome-transcriptome analyses establishes quantitatively distinct receptor genomic interactions in African American prostate cancer regulated by BAZ1A

Siddappa, M.; Hussain, S.; Wani, S. A.; Tang, H.; Jafari, H.; Gray, J. S.; Long, M. D.; Elhussin, I.; Karanam, B.; Wang, H.; Morgan, R.; Hardiman, G.; Adelani, I. B.; Rotimi, S.; Murphy, A. R.; Nonn, L.; Davis, M. B.; Kittles, R. A.; Hughes Halbert, C.; Sucheston-Campbell, L. E.; Yates, C.; Campbell, M. J.

10.1101/2022.01.31.478573 — cancer biology — Posted on 2022-02-01

3623 AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

Ghosh, P.; Campos, V. J.; Vo, D. T.; Guccione, C.; Goheen-Holland, V.; Tindle, C.; Mazzini, G. S.; He, Y.; Alexandrov, L.; Lippman, S. M.; Gurski, R.; Das, S.; Curtius, K.; Yadlapati, R.; Sahoo, D.

10.1101/2022.01.30.478408 — cancer biology — Posted on 2022-02-01

3624 Monocarboxylate Transporters are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma

Ufuk, A.; Garner, T.; Stevens, A.; Latif, A.

10.1101/2022.02.01.478448 — cancer biology — Posted on 2022-02-01

3625 Clonal diversification and histogenesis of malignant germ cell tumours

Oliver, T. R. W.; Chappell, L.; Sanghvi, R.; Deighton, L.; Ansari-Pour, N.; Dentro, S.; Young, M. D.; Coorens, T. H. H.; Jung, H.; Butler, T. M.; Neville, M. D. C.; Leongamornlert, D.; Sanders, M. A.; Hooks, Y.; Cagan, A.; Mitchell, T. J.; Cortes-Ciriano, I.; Warren, A. Y.; Wedge, D. C.; Heer, R.; Coleman, N.; Murray, M. J.; Campbell, P. J.; Rahbari, R.; Behjati, S.

10.1101/2022.02.01.478621 — cancer biology — Posted on 2022-02-01

3626 Constraint-based modeling identifies metabolic vulnerabilities during the epithelial to mesenchymal transition

Campit, S. E.; Keshamouni, V. G.; Chandrasekaran, S.

10.1101/2022.01.31.478483 — cancer biology — Posted on 2022-02-01

3627 PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets

Wunderlich, M.; Chen, J.; Sexton, C.; Byerly, L.; O'Brien, E.; Perentesis, J. P.; Mulloy, J. C.; Mizukawa, B.

10.1101/2022.01.31.478534 — cancer biology — Posted on 2022-02-01

3628 HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

Apfelbaum, A. A.; Wu, F.; Hawkins, A.; Jimenez, J. A.; Taylor, S. D.; Pfaltzgraff, E. R.; Song, J. Y.; Hall, C.; Wellik, D. M.; Ljungman, M.; Furlan, S. N.; Ryan, R. J. H.; Sarthy, J. F.; Lawlor, E. R.

10.1101/2022.01.31.478548 — cancer biology — Posted on 2022-02-01

3629 Histone deacetylase inhibitor induces acetyl-CoA depletion leading to lethal metabolic stress in RAS-pathway activated cells

Basseville, A.; Violet, P.-C.; Safari, M.; Sourbier, C.; Linehan, M.; Robey, R. W.; Levine, M.; Sackett, D. L.; Bates, S. E.

10.1101/2022.01.31.478570 — cancer biology — Posted on 2022-02-01

3630 Secretin receptor as a target in gastrointestinal cancer: expression analysis and ligand development

Klussmeier, A.; Aurich, S.; Niederstadt, L.; Wiedenmann, B.; Groetzinger, C.

10.1101/2022.01.31.478443 — cancer biology — Posted on 2022-02-01

3631 Evidence for close molecular proximity between reverting and undifferentiated cells

Zreika, S.; Fourneaux, C.; Vallin, E.; Modolo, L.; Seraphin, R.; Moussy, A.; Elias, V.; Bouvier, M.; Ozier-Lafontaine, A.; Bonnaffoux, A.; Picard, F.; Gandrillon, O.; Gonin-Giraud, S.

10.1101/2022.02.01.478637 — cell biology — Posted on 2022-02-01

3632 CDK11 Promotes Centromeric Transcription to Maintain Centromeric Cohesion during Mitosis

Liu, H.; Zhang, Q.; Chen, Y.; Teng, Z.; Lin, Z.

10.1101/2022.02.01.478617 — cell biology — Posted on 2022-02-01

3633 Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

Pranke, I. M.; Chevalier, B.; Premchandar, A.; Baatallah, N.; Tomaszewski, K. F.; Bitam, S.; Tondelier, D.; Golec, A.; Stolk, J.; Lukacs, G. L.; Hiemstra, P. S.; Dadlez, M.; Lomas, D. A.; Irving, J. A.; Delaunay-Moisan, A.; van Anken, E.; Hinzpeter, A.; Sermet-Gaudelus, I.; Edelman, A.

10.1101/2022.02.01.478623 — cell biology — Posted on 2022-02-01

3634 Learning probabilistic protein-DNA recognition codes from DNA-binding specificities using structural mappings

Wetzel, J. L.; Zhang, K.; Singh, M.

10.1101/2022.01.31.477772 — molecular biology — Posted on 2022-02-01

3635 Amyloid fibrils in frontotemporal lobar degeneration with TDP-43 inclusions are composed of TMEM106B, rather than TDP-43

Jiang, Y. X.; Cao, Q.; Sawaya, M. R.; Abskharon, R.; Ge, P.; DeTure, M.; Dickson, D. W.; Fu, J. Y.; Ogorzalek Loo, R. R.; Loo, J. A.; Eisenberg, D. S.

10.1101/2022.01.31.478523 — molecular biology — Posted on 2022-02-01

3636 Discovery of novel therapeutic targets in cancer using patient-specific gene regulatory networks.

Forbes, A. N.; Xu, D.; Cohen, S.; Pancholi, P.; Khurana, E.

10.1101/2022.01.31.478503 — systems biology — Posted on 2022-02-01

3637 G protein-coupled oestrogen receptor activation by Bisphenol-A disrupts protection from apoptosis conferred by oestrogen receptors ERα and ERβ in pancreatic beta cells

Babiloni-Chust, I.; Dos Santos, R. S.; Medina-Gali, R. M.; Perez-Serna, A. A.; Encinar, J. A.; Martinez-Pinna, J.; Gustafsson, J.-A.; Marroqui, L.; Nadal, A.

10.1101/2022.01.31.478472 — physiology — Posted on 2022-02-01

3638 Quantification of phosphonate drugs by 1H-31P HSQC shows that rats are better models of primate drug exposure than mice

Barekatain, Y.; Khadka, S.; Harris, K.; Delacerda, J.; Yan, V. C.; Chen, K.-C.; Pham, C.-D.; Uddin, M. N.; Avritcher, R.; Eisenberg, E. J.; Kalluri, R.; Millward, S. W.; Muller, F. L.

10.1101/2022.01.30.478340 — pharmacology and toxicology — Posted on 2022-02-01

3639 Rhythmic Cilium in SCN Neuron is a Gatekeeper for the Intrinsic Circadian Clock

Hai-Qing, T.; Sen, L.; Yu-Ling, X.; Yu-Cheng, Z.; Xiao-Xiao, J.; Guang-Ping, S.; Min, W.; Zeng-Qing, S.; Huai-Bin, H.; Pei-Yao, L.; Li-Yun, L.; Jin-Feng, Y.; Xiao-Lin, S.; Jia-Ning, L.; Qiu-Ying, H.; Kai, W.; Tao, Z.; Tao, Z.; Ai-Ling, L.; Xue-Min, Z.; Hui-Yan, L.

10.1101/2022.01.26.477948 — neuroscience — Posted on 2022-02-01

3640 Spatiotemporal dissociation of brain network connectivity in salience processing: A simultaneous pupillometry-EEG-fMRI study

He, H.; Hong, L.; Sajda, P.

10.1101/2022.01.29.478345 — neuroscience — Posted on 2022-02-01

3641 Composite branch construction by dual autozooidal budding modes in hornerids (Bryozoa: Cyclostomatida)

Batson, P. B.; Tamberg, Y.; Taylor, P. D.

10.1101/2022.01.30.478354 — zoology — Posted on 2022-02-01

3642 Combined free energy calculation and machine learning methods for understanding ligand unbinding kinetics

Badaoui, M.; Buigues, P. J.; Berta, D.; Mandana, G. M.; Gu, H.; Földes, T.; Dickson, C. J.; Hornak, V.; Kato, M.; Molteni, C.; Parsons, S. D.; Rosta, E.

10.1101/2021.09.08.459492 — biophysics — Posted on 2022-02-01

3643 Combined docking and machine learning identifies key molecular determinants of ligand pharmacological activity on β2 adrenoceptor.

Jimenez-Roses, M.; Morgan, B. A.; Jimenez Sigstad, M.; Tran, T. D. Z.; Srivastava, R.; Bunsuz, A.; Borrega Roman, L.; Hompluem, P.; Cullum, S. A.; Harwood, C. R.; Koers, E. J.; Sykes, D. A.; Styles, I. B.; Veprintsev, D. B.

10.1101/2021.03.18.434755 — bioinformatics — Posted on 2022-02-01

3644 HiC-LDNet: A general and robust deep learning framework for accurate chromatin loop detection in genome-wide contact maps

Chen, S.; Wang, J.; Gao, X.; Li, Y.

10.1101/2022.01.30.478367 — bioinformatics — Posted on 2022-02-01

3645 Group-walk, a rigorous approach to separate FDR analysis by TDC

Freestone, J.; Short, T.; Noble, W. S.; Keich, U.

10.1101/2022.01.30.478144 — bioinformatics — Posted on 2022-02-01

3646 Preferred Conformations in the Intrinsically Disordered Region of Human CPEB3, a Functional Amyloid Linked to Memory Consolidation

Ramirez de Mingo, D.; Pantoja-Uceda, D.; Hervas, R.; Carrion-Vazquez, M.; Laurents, D. V.

10.1101/2020.05.12.091587 — biochemistry — Posted on 2022-02-01

3647 Electroencephalographic Signatures of Canine Cognitive Dysfunction

Mondino, A.; Gutierrez, M.; Gonzalez, C.; Mateos, D.; Torterolo, P.; Olby, N.; Delucchi, L.

10.1101/2022.01.28.478033 — animal behavior and cognition — Posted on 2022-02-01

3648 Genome annotation of Caenorhabditis briggsae by TEC-RED identifies new exons, paralogs, and conserved and novel operons

Jhaveri, N.; van den Berg, W.; Hwang, B. J.; Muller, H.-M.; Sternberg, P. W.; Gupta, B. P.

10.1101/2021.09.24.461604 — evolutionary biology — Posted on 2022-02-01

3649 Scientific modelling can be accessible, interoperable and user friendly: An example for pasture and livestock modelling

Marquez Torres, A.; Balbi, S.; Villa, F.

10.1101/2021.02.23.432363 — ecology — Posted on 2022-02-01

3650 The AAA-ATPase Atad1 and its partners promote degradation of desmin intermediate filaments in muscle

Aweida, D.; Cohen, S.

10.1101/2022.01.24.477493 — cell biology — Posted on 2022-02-01

3651 A Network-level Test of the Role of the Co-activated Default Mode Network in Episodic Recall and Social Cognition

Jackson, R. L.; Humphreys, G. F.; Rice, G. E.; Binney, R. J.; Lambon Ralph, M. A.

10.1101/2021.01.08.425921 — neuroscience — Posted on 2022-02-01

3652 Variation of the Rdr1 gene insertion in wild populations of Nicotiana benthamiana (Solanaceae) and insights into recent species divergence

Cauz-Santos, L. A.; Dodsworth, S.; Samuel, R.; Christenhusz, M. J. M.; Patel, D.; Shittu, T.; Jakob, A.; Paun, O.; Chase, M. W.

10.1101/2022.02.01.478068 — evolutionary biology — Posted on 2022-02-01

3653 Effects of global change on animal biodiversity in boreal forest landscape: an assemblage dissimilarity analysis

Bouderbala, I.; Labadie, G.; Beland, J.-M.; Boulanger, Y.; Hebert, C.; Desrosiers, P.; Allard, A.; Fortin, D.

10.1101/2022.01.31.477297 — ecology — Posted on 2022-02-01

3654 Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

Donovan Banfield, I.; Hall, S.; Gao, T.; Murphy, E.; Li, J.; Shawli, G.; Hiscox, J. A.; Fearns, R.; Matthews, D. A.

10.1101/2021.12.23.473996 — microbiology — Posted on 2022-02-01

3655 Novel Association of Lyme Disease, Age, and Atopic Dermatitis

10.1101/2022.01.27.476641 — immunology — Posted on 2022-02-01

3656 High performance liquid chromatography-based metabolomics of Psidium guajava Linn. leaf extracts

Gholkar, M. S.; Daswani, P. G.; Iyer, V. V.; Birdi, T. J.

10.1101/2022.01.25.477015 — systems biology — Posted on 2022-02-01

3657 Spatial control of cell division by GA-OsGRF7/8 module in a leaf explains the leaf length variation between cultivated and wild rice

Jathar, V.; Saini, K.; Chauhan, A.; Rani, R.; Ichihashi, Y.; Ranjan, A.

10.1101/2021.05.06.443003 — plant biology — Posted on 2022-02-01

3658 Flexible seed size enables ultra-fast and accurate read alignment

Sahlin, K.

10.1101/2021.06.18.449070 — bioinformatics — Posted on 2022-02-01

3659 Finding landmarks - An investigation of viewing behavior during spatial navigation in VR using a graph-theoretical analysis approach

Walter, J. L.; Essmann, L.; König, S. U.; König, P.

10.1101/2021.09.29.462279 — neuroscience — Posted on 2022-02-01

3660 A novel approach to the functional classification of retinal ganglion cells

Hilgen, G.; Kartsaki, E.; Kartysh, V.; Cessac, B.; Sernagor, E.

10.1101/2021.05.09.443323 — neuroscience — Posted on 2022-02-01

3661 Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory

Dick, A. S.; Ralph, Y.; Farrant, K.; Reeb-Sutherland, B.; Pruden, S.; Mattfeld, A.

10.1101/2022.01.31.478590 — neuroscience — Posted on 2022-02-01

3662 FAIRly big: A framework for computationally reproducible processing of large-scale data

Wagner, A. S.; Waite, L. K.; Wierzba, M.; Hoffstaedter, F.; Waite, A. Q.; Poldrack, B.; Eickhoff, S. B.; Hanke, M.

10.1101/2021.10.12.464122 — bioinformatics — Posted on 2022-02-01

3663 A genomic snapshot of demographic and cultural dynamism in Upper Mesopotamia during the Neolithic Transition

Altinisik, N. E.; Kazanci, D. D.; Aydogan, A.; Gemici, H. C.; Erdal, O. D.; Sarialtun, S.; Vural, K. B.; Koptekin, D.; Gurun, K.; Saglican, E.; Cakan, G.; Koruyucu, M. M.; Lagerholm, V. K.; Karamurat, C.; Ozkan, M.; Klinc, G. M.; Sevkar, A.; Surer, E.; Gotherstrom, A.; Atakuman, C.; Erdal, Y. S.; Ozer, F.; Erim-Ozdogan, A.; Somel, M.

10.1101/2022.01.31.478487 — genetics — Posted on 2022-02-01

3664 In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states

Melanker, O.; Goloubinoff, P. A.; Schreiber, G.

10.1101/2021.11.30.470542 — evolutionary biology — Posted on 2022-02-01

3665 Striatal dopamine encodes the relationship between actions and reward

Hart, G.; Burton, T. J.; Balleine, B.

10.1101/2022.01.31.478585 — neuroscience — Posted on 2022-02-01

3666 Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by Neuron Navigator 1

Powers, R.; Daza, R.; Koehler, A. E.; Courchet, J.; Calabrese, B.; Hevner, R.; Halpain, S.

10.1101/2022.01.31.478516 — neuroscience — Posted on 2022-02-01

Archive, 2022-02